HUMAN|HGNC=12825|UniProtKB=O14980 O14980 XPO1 PTHR11223:SF2 EXPORTIN 1/5 EXPORTIN-1 nucleocytoplasmic carrier activity#GO:0140142;molecular carrier activity#GO:0140104 ribosome biogenesis#GO:0042254;organelle localization#GO:0051640;ribosomal small subunit export from nucleus#GO:0000056;nucleocytoplasmic transport#GO:0006913;ribosome localization#GO:0033750;cellular localization#GO:0051641;localization#GO:0051179;nuclear export#GO:0051168;nuclear transport#GO:0051169;ribosomal large subunit export from nucleus#GO:0000055;establishment of organelle localization#GO:0051656;ribonucleoprotein complex biogenesis#GO:0022613;ribosomal subunit export from nucleus#GO:0000054;intracellular transport#GO:0046907;transport#GO:0006810;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;establishment of localization in cell#GO:0051649 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 transporter#PC00227 HUMAN|HGNC=23074|UniProtKB=Q9NX70 Q9NX70 MED29 PTHR28314:SF1 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 29 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 29 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;mediator complex#GO:0016592;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231 general transcription factor#PC00259 HUMAN|HGNC=2372|UniProtKB=Q9ULK4 Q9ULK4 MED23 PTHR12691:SF10 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 23 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 23 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;mediator complex#GO:0016592;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229 general transcription factor#PC00259 HUMAN|HGNC=50322|UniProtKB=P0DP04 P0DP04 IGHV3-43D PTHR23266:SF236 IMMUNOGLOBULIN HEAVY CHAIN IG-LIKE DOMAIN-CONTAINING PROTEIN-RELATED antigen binding#GO:0003823;binding#GO:0005488 immune response#GO:0006955;adaptive immune response#GO:0002250;response to stimulus#GO:0050896;immune effector process#GO:0002252;immune system process#GO:0002376;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=1641|UniProtKB=Q9NNX6 Q9NNX6 CD209 PTHR22802:SF197 C-TYPE LECTIN SUPERFAMILY MEMBER CD209 ANTIGEN binding#GO:0005488;small molecule binding#GO:0036094;pattern recognition receptor activity#GO:0038187;carbohydrate binding#GO:0030246;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;monosaccharide binding#GO:0048029 immune response#GO:0006955;immune system process#GO:0002376;response to stimulus#GO:0050896 membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell surface#GO:0009986;plasma membrane#GO:0005886 membrane traffic protein#PC00150 HUMAN|HGNC=26933|UniProtKB=Q5T280 Q5T280 SPOUT1 PTHR12150:SF14 CLASS IV SAM-BINDING METHYLTRANSFERASE-RELATED 28S RRNA (URIDINE-N(3))-METHYLTRANSFERASE nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 regulatory ncRNA-mediated gene silencing#GO:0031047;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulatory ncRNA processing#GO:0070918;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;macromolecule biosynthetic process#GO:0009059;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biosynthetic process#GO:0009058;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;organelle localization#GO:0051640;localization#GO:0051179;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;RNA processing#GO:0006396;gene expression#GO:0010467;miRNA processing#GO:0035196;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;cellular localization#GO:0051641;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;negative regulation of metabolic process#GO:0009892;centrosome localization#GO:0051642 chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitotic spindle#GO:0072686;spindle pole#GO:0000922;chromosome#GO:0005694;kinetochore#GO:0000776;membraneless organelle#GO:0043228;spindle#GO:0005819;centrosome#GO:0005813;microtubule organizing center#GO:0005815;chromosome, centromeric region#GO:0000775;condensed chromosome#GO:0000793;cytoskeleton#GO:0005856;supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;condensed chromosome, centromeric region#GO:0000779 metabolite interconversion enzyme#PC00262;methyltransferase#PC00155 HUMAN|HGNC=29060|UniProtKB=Q658N2 Q658N2 WSCD1 PTHR45964:SF8 WSCD FAMILY MEMBER CG9164 SIALATE:O-SULFOTRANSFERASE 1 HUMAN|HGNC=25954|UniProtKB=Q8TBK6 Q8TBK6 ZCCHC10 PTHR13491:SF0 ZCCHC10 PROTEIN ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 10 HUMAN|HGNC=26073|UniProtKB=Q9BVV8 Q9BVV8 FAM174C PTHR28607:SF2 EXPRESSED PROTEIN PROTEIN FAM174C extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=25532|UniProtKB=Q9NVV4 Q9NVV4 MTPAP PTHR12271:SF133 POLY A POLYMERASE CID PAP -RELATED POLY(A) RNA POLYMERASE, MITOCHONDRIAL catalytic activity, acting on RNA#GO:0140098;adenylyltransferase activity#GO:0070566;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a nucleic acid#GO:0140640;nucleotidyltransferase activity#GO:0016779;transferase activity#GO:0016740;catalytic activity#GO:0003824 positive regulation of RNA metabolic process#GO:0051254;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;positive regulation of mRNA catabolic process#GO:0061014;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of RNA metabolic process#GO:0051252;regulation of RNA stability#GO:0043487;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;macromolecule biosynthetic process#GO:0009059;nucleic acid catabolic process#GO:0141188;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;nucleobase-containing compound catabolic process#GO:0034655;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;regulation of biosynthetic process#GO:0009889;positive regulation of catabolic process#GO:0009896;macromolecule metabolic process#GO:0043170;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;regulation of mRNA stability#GO:0043488;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;regulation of biological quality#GO:0065008;RNA metabolic process#GO:0016070;positive regulation of metabolic process#GO:0009893;modification-dependent macromolecule catabolic process#GO:0043632;nucleic acid biosynthetic process#GO:0141187;RNA catabolic process#GO:0006401;RNA processing#GO:0006396;gene expression#GO:0010467;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;RNA destabilization#GO:0050779;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA processing#GO:0006397;regulation of mRNA metabolic process#GO:1903311;RNA 3'-end processing#GO:0031123;positive regulation of mRNA metabolic process#GO:1903313;macromolecule catabolic process#GO:0009057;mRNA destabilization#GO:0061157;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;mRNA 3'-end processing#GO:0031124 mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 nucleotidyltransferase#PC00174 HUMAN|HGNC=7110|UniProtKB=Q9BUB5 Q9BUB5 MKNK1 PTHR24349:SF114 SERINE/THREONINE-PROTEIN KINASE MAP KINASE-INTERACTING SERINE_THREONINE-PROTEIN KINASE 1 calcium/calmodulin-dependent protein kinase activity#GO:0004683;binding#GO:0005488;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein binding#GO:0005515;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;calmodulin binding#GO:0005516;catalytic activity, acting on a protein#GO:0140096 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 Oxidative stress response#P00046>MNK1/2#P01137;Interleukin signaling pathway#P00036>MNK1/2#P00972;PDGF signaling pathway#P00047>MNK1/2#P01149;p38 MAPK pathway#P05918>MNK1#P06018 HUMAN|HGNC=29160|UniProtKB=Q9NYY8 Q9NYY8 FASTKD2 PTHR21228:SF1 FAST LEU-RICH DOMAIN-CONTAINING FAST KINASE DOMAIN-CONTAINING PROTEIN 2, MITOCHONDRIAL nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;post-transcriptional regulation of gene expression#GO:0010608;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;macromolecule biosynthetic process#GO:0009059;mitochondrial RNA processing#GO:0000963;mitochondrial RNA metabolic process#GO:0000959;regulation of RNA metabolic process#GO:0051252;mitochondrial gene expression#GO:0140053;regulation of RNA stability#GO:0043487;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of mRNA metabolic process#GO:1903311;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;gene expression#GO:0010467;RNA processing#GO:0006396;cellular process#GO:0009987;RNA metabolic process#GO:0016070;regulation of biological quality#GO:0065008;nucleic acid biosynthetic process#GO:0141187;regulation of mRNA stability#GO:0043488;regulation of mRNA catabolic process#GO:0061013;regulation of biological process#GO:0050789 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;organelle lumen#GO:0043233;membraneless organelle#GO:0043228;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;membrane-enclosed lumen#GO:0031974 RNA processing factor#PC00147 HUMAN|HGNC=25980|UniProtKB=Q9NXH9 Q9NXH9 TRMT1 PTHR10631:SF14 N 2 ,N 2 -DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE TRNA (GUANINE(26)-N(2))-DIMETHYLTRANSFERASE tRNA methyltransferase activity#GO:0008175;RNA methyltransferase activity#GO:0008173;catalytic activity, acting on RNA#GO:0140098;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a tRNA#GO:0140101;tRNA (guanine) methyltransferase activity#GO:0016423;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;N-methyltransferase activity#GO:0008170 gene expression#GO:0010467;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 RNA methyltransferase#PC00033;RNA metabolism protein#PC00031 HUMAN|HGNC=9213|UniProtKB=P09086 P09086 POU2F2 PTHR11636:SF46 POU DOMAIN POU DOMAIN, CLASS 2, TRANSCRIPTION FACTOR 2 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular organelle#GO:0043229 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=20672|UniProtKB=Q9UPP1 Q9UPP1 PHF8 PTHR23123:SF11 PHD/F-BOX CONTAINING PROTEIN HISTONE LYSINE DEMETHYLASE PHF8 catalytic activity#GO:0003824;histone demethylase activity#GO:0032452;protein demethylase activity#GO:0140457;demethylase activity#GO:0032451;catalytic activity, acting on a protein#GO:0140096;histone modifying activity#GO:0140993 chromatin organization#GO:0006325;chromatin remodeling#GO:0006338;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 histone modifying enzyme#PC00261;chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=3212|UniProtKB=O43324 O43324 EEF1E1 PTHR44490:SF1 EUKARYOTIC TRANSLATION ELONGATION FACTOR 1 EPSILON-1 EUKARYOTIC TRANSLATION ELONGATION FACTOR 1 EPSILON-1 molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;enzyme activator activity#GO:0008047;kinase activator activity#GO:0019209 positive regulation of intracellular signal transduction#GO:1902533;regulation of apoptotic process#GO:0042981;regulation of response to stimulus#GO:0048583;regulation of response to stress#GO:0080134;positive regulation of apoptotic process#GO:0043065;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of response to stimulus#GO:0048584;regulation of signaling#GO:0023051;regulation of apoptotic signaling pathway#GO:2001233;regulation of intracellular signal transduction#GO:1902531;regulation of cellular response to stress#GO:0080135;positive regulation of signaling#GO:0023056;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;regulation of programmed cell death#GO:0043067;positive regulation of apoptotic signaling pathway#GO:2001235;regulation of cell communication#GO:0010646;positive regulation of cell communication#GO:0010647;positive regulation of programmed cell death#GO:0043068;regulation of cellular process#GO:0050794 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 translation factor#PC00223;translation elongation factor#PC00222 HUMAN|HGNC=21021|UniProtKB=Q5SYE7 Q5SYE7 NHSL1 PTHR23039:SF3 NANCE-HORAN SYNDROME PROTEIN NHS-LIKE PROTEIN 1 HUMAN|HGNC=4910|UniProtKB=Q16665 Q16665 HIF1A PTHR23043:SF7 HYPOXIA-INDUCIBLE FACTOR 1 ALPHA HYPOXIA-INDUCIBLE FACTOR 1-ALPHA sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular response to stress#GO:0033554;cellular response to chemical stimulus#GO:0070887;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to decreased oxygen levels#GO:0036293;response to oxygen levels#GO:0070482;response to abiotic stimulus#GO:0009628;cellular response to hypoxia#GO:0071456;homeostatic process#GO:0042592;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;chemical homeostasis#GO:0048878;response to hypoxia#GO:0001666;intracellular chemical homeostasis#GO:0055082;regulation of gene expression#GO:0010468;cellular homeostasis#GO:0019725;regulation of biosynthetic process#GO:0009889;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;response to stress#GO:0006950;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;response to chemical#GO:0042221 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 Angiogenesis#P00005>HIF-1#P00214;Hypoxia response via HIF activation#P00030>HIF-1alpha#P00818;VEGF signaling pathway#P00056>HIF-1#P01401 HUMAN|HGNC=5409|UniProtKB=P09913 P09913 IFIT2 PTHR10271:SF4 INTERFERON-INDUCED PROTEIN WITH TETRATRICOPEPTIDE REPEATS INTERFERON-INDUCED PROTEIN WITH TETRATRICOPEPTIDE REPEATS 2 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 immune system process#GO:0002376;response to virus#GO:0009615;response to peptide#GO:1901652;defense response to virus#GO:0051607;cellular response to cytokine stimulus#GO:0071345;antiviral innate immune response#GO:0140374;response to stimulus#GO:0050896;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;innate immune response#GO:0045087;response to external stimulus#GO:0009605;defense response#GO:0006952;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;defense response to symbiont#GO:0140546;immune response#GO:0006955;response to chemical#GO:0042221;response to cytokine#GO:0034097;defense response to other organism#GO:0098542;response to other organism#GO:0051707 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 defense/immunity protein#PC00090 HUMAN|HGNC=6369|UniProtKB=O60259 O60259 KLK8 PTHR24271:SF62 KALLIKREIN-RELATED KALLIKREIN-8 serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;serine-type peptidase activity#GO:0008236 protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152 intracellular organelle#GO:0043229;extracellular region#GO:0005576;membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular vesicle#GO:0097708;secretory vesicle#GO:0099503;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 serine protease#PC00203 HUMAN|HGNC=29213|UniProtKB=Q8WUJ3 Q8WUJ3 CEMIP PTHR15535:SF15 TRANSMEMBRANE PROTEIN 2-RELATED CELL MIGRATION-INDUCING AND HYALURONAN-BINDING PROTEIN hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 carbohydrate derivative catabolic process#GO:1901136;catabolic process#GO:0009056;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;glycosaminoglycan metabolic process#GO:0030203;macromolecule metabolic process#GO:0043170;aminoglycan catabolic process#GO:0006026;glycosaminoglycan catabolic process#GO:0006027;metabolic process#GO:0008152;aminoglycan metabolic process#GO:0006022;macromolecule catabolic process#GO:0009057 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HUMAN|HGNC=9871|UniProtKB=P20936 P20936 RASA1 PTHR10194:SF146 RAS GTPASE-ACTIVATING PROTEINS RAS GTPASE-ACTIVATING PROTEIN 1 GTPase-activating protein#PC00257 Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>Ras#P00886;EGF receptor signaling pathway#P00018>GAP#P00546;PDGF signaling pathway#P00047>RasGAP#P01152;FGF signaling pathway#P00021>RasGAP#P00646;Interleukin signaling pathway#P00036>RasGAP#P00975;Angiogenesis#P00005>GAP#P00205;Angiogenesis#P00005>RasGAP#P00190 HUMAN|HGNC=17270|UniProtKB=Q96RG2 Q96RG2 PASK PTHR24346:SF51 MAP/MICROTUBULE AFFINITY-REGULATING KINASE PAS DOMAIN-CONTAINING SERINE_THREONINE-PROTEIN KINASE phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 regulation of macromolecule metabolic process#GO:0060255;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of carbohydrate biosynthetic process#GO:0043255;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of polysaccharide metabolic process#GO:0032881;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of polysaccharide biosynthetic process#GO:0032885;regulation of biosynthetic process#GO:0009889;regulation of carbohydrate metabolic process#GO:0006109;negative regulation of cellular process#GO:0048523;regulation of glycogen biosynthetic process#GO:0005979 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=17843|UniProtKB=Q96RS0 Q96RS0 TGS1 PTHR14741:SF32 S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE RELATED TRIMETHYLGUANOSINE SYNTHASE catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;catalytic activity#GO:0003824;RNA methyltransferase activity#GO:0008173;catalytic activity, acting on RNA#GO:0140098;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757 RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA metabolic process#GO:0016070;RNA methylation#GO:0001510;macromolecule modification#GO:0043412;methylation#GO:0032259;macromolecule methylation#GO:0043414;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 RNA methyltransferase#PC00033;RNA metabolism protein#PC00031 HUMAN|HGNC=16919|UniProtKB=Q99536 Q99536 VAT1 PTHR44054:SF1 SYNAPTIC VESICLE MEMBRANE PROTEIN VAT-1 HOMOLOG-LIKE NADPH-DEPENDENT QUINONE OXIDOREDUCTASE VAT1 biological regulation#GO:0065007;regulation of developmental process#GO:0050793;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of mitochondrion organization#GO:0010821;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;negative regulation of biological process#GO:0048519;negative regulation of cellular component organization#GO:0051129;negative regulation of organelle organization#GO:0010639;regulation of anatomical structure morphogenesis#GO:0022603;negative regulation of cellular process#GO:0048523 organelle envelope#GO:0031967;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;outer membrane#GO:0019867;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;organelle outer membrane#GO:0031968;cytoplasm#GO:0005737;mitochondrial outer membrane#GO:0005741;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090 Huntington disease#P00029>PIG3#G01535 HUMAN|HGNC=13017|UniProtKB=Q9NZL3 Q9NZL3 ZNF224 PTHR24376:SF129 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 224-RELATED gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HUMAN|HGNC=2591|UniProtKB=P15538 P15538 CYP11B1 PTHR24279:SF115 CYTOCHROME P450 CYTOCHROME P450 11B1, MITOCHONDRIAL steroid hydroxylase activity#GO:0008395;catalytic activity#GO:0003824;monooxygenase activity#GO:0004497;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;oxidoreductase activity#GO:0016491 response to nitrogen compound#GO:1901698;cellular response to peptide hormone stimulus#GO:0071375;hormone biosynthetic process#GO:0042446;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;sterol metabolic process#GO:0016125;steroid biosynthetic process#GO:0006694;small molecule biosynthetic process#GO:0044283;cholesterol metabolic process#GO:0008203;lipid metabolic process#GO:0006629;cellular response to nitrogen compound#GO:1901699;lipid biosynthetic process#GO:0008610;hormone metabolic process#GO:0042445;response to peptide hormone#GO:0043434;biological regulation#GO:0065007;biosynthetic process#GO:0009058;regulation of biological quality#GO:0065008;olefinic compound metabolic process#GO:0120254;cellular response to chemical stimulus#GO:0070887;response to oxygen-containing compound#GO:1901700;cellular response to hormone stimulus#GO:0032870;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;secondary alcohol metabolic process#GO:1902652;ketone metabolic process#GO:0042180;response to endogenous stimulus#GO:0009719;regulation of hormone levels#GO:0010817;alcohol metabolic process#GO:0006066;metabolic process#GO:0008152;response to chemical#GO:0042221;steroid metabolic process#GO:0008202;response to hormone#GO:0009725;aldehyde metabolic process#GO:0006081;ketone biosynthetic process#GO:0042181;cellular process#GO:0009987;alcohol biosynthetic process#GO:0046165;cellular response to oxygen-containing compound#GO:1901701 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrial inner membrane#GO:0005743;organelle envelope#GO:0031967;membrane#GO:0016020;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;intracellular organelle#GO:0043229 HUMAN|HGNC=16443|UniProtKB=Q5VXU1 Q5VXU1 NKAIN2 PTHR13084:SF3 T-CELL LYMPHOMA BREAKPOINT-ASSOCIATED TARGET 1-RELATED SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA-1-INTERACTING PROTEIN 2 regulation of localization#GO:0032879;biological regulation#GO:0065007;regulation of transport#GO:0051049;regulation of monoatomic ion transport#GO:0043269;regulation of metal ion transport#GO:0010959;regulation of biological process#GO:0050789 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=25424|UniProtKB=Q8N567 Q8N567 ZCCHC9 PTHR46242:SF1 ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 9 ZCCHC9 ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 9 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 HUMAN|HGNC=23746|UniProtKB=Q7Z6G3 Q7Z6G3 NECAB2 PTHR12178:SF2 EF-HAND DOMAIN-CONTAINING PROTEIN N-TERMINAL EF-HAND CALCIUM-BINDING PROTEIN 2 regulation of biosynthetic process#GO:0009889;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=20822|UniProtKB=Q9HBW9 Q9HBW9 ADGRL4 PTHR12011:SF59 ADHESION G-PROTEIN COUPLED RECEPTOR ADHESION G PROTEIN-COUPLED RECEPTOR L4 transmembrane signaling receptor activity#GO:0004888;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=28187|UniProtKB=Q8WUU8 Q8WUU8 TMEM174 PTHR31020:SF1 TRANSMEMBRANE PROTEIN 174 TRANSMEMBRANE PROTEIN 174 HUMAN|HGNC=32291|UniProtKB=Q6ZNC4 Q6ZNC4 ZNF704 PTHR13006:SF7 PAPILLOMAVIRUS REGULATORY FACTOR PRF-1 ZINC FINGER PROTEIN 704 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 transcription cofactor#PC00217 HUMAN|HGNC=9906|UniProtKB=O43251 O43251 RBFOX2 PTHR15597:SF31 ATAXIN 2-BINDING PROTEIN 1-RELATED RNA BINDING PROTEIN FOX-1 HOMOLOG 2 binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723 regulation of biological process#GO:0050789;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;animal gross anatomical part developmental process#GO:0160108;anatomical structure development#GO:0048856;regulation of alternative mRNA splicing, via spliceosome#GO:0000381;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of mRNA processing#GO:0050684;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;regulation of RNA splicing#GO:0043484;nervous system development#GO:0007399;developmental process#GO:0032502;multicellular organism development#GO:0007275;regulation of mRNA metabolic process#GO:1903311;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 RNA processing factor#PC00147;RNA splicing factor#PC00148 HUMAN|HGNC=13542|UniProtKB=O60312 O60312 ATP10A PTHR24092:SF81 PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE PHOSPHOLIPID-TRANSPORTING ATPASE VA lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104;ATPase-coupled intramembrane lipid carrier activity#GO:0140326;transporter activity#GO:0005215;ATP-dependent activity#GO:0140657;intramembrane lipid carrier activity#GO:0140303 organophosphate ester transport#GO:0015748;lipid translocation#GO:0034204;cellular component organization#GO:0016043;localization#GO:0051179;regulation of biological quality#GO:0065008;lipid localization#GO:0010876;lipid transport#GO:0006869;membrane organization#GO:0061024;biological regulation#GO:0065007;phospholipid transport#GO:0015914;phospholipid translocation#GO:0045332;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;regulation of membrane lipid distribution#GO:0097035;transport#GO:0006810 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 primary active transporter#PC00068;transporter#PC00227 HUMAN|HGNC=23106|UniProtKB=Q6NSW7 Q6NSW7 NANOGP8 PTHR24327:SF79 HOMEOBOX PROTEIN HOMEOBOX PROTEIN NANOG-RELATED cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 maintenance of cell number#GO:0098727;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;stem cell population maintenance#GO:0019827;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;developmental process#GO:0032502;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889 gene-specific transcriptional regulator#PC00264;helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=2378|UniProtKB=O43513 O43513 MED7 PTHR15498:SF72 T-CELL IMMUNOGLOBULIN AND MUCIN DOMAIN CONTAINING TIM MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;mediator complex#GO:0016592;intracellular anatomical structure#GO:0005622 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=22954|UniProtKB=Q8NBL1 Q8NBL1 POGLUT1 PTHR12203:SF126 KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED PROTEIN O-GLUCOSYLTRANSFERASE 1 pentosyltransferase activity#GO:0016763;xylosyltransferase activity#GO:0042285;glucosyltransferase activity#GO:0046527;catalytic activity#GO:0003824;transferase activity#GO:0016740;UDP-xylosyltransferase activity#GO:0035252;hexosyltransferase activity#GO:0016758;UDP-glucosyltransferase activity#GO:0035251;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757 glycoprotein biosynthetic process#GO:0009101;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein O-linked glycosylation#GO:0006493;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;carbohydrate derivative metabolic process#GO:1901135;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;biosynthetic process#GO:0009058;metabolic process#GO:0008152;regulation of response to stimulus#GO:0048583;glycoprotein metabolic process#GO:0009100;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;positive regulation of Notch signaling pathway#GO:0045747;regulation of cell communication#GO:0010646;regulation of Notch signaling pathway#GO:0008593;regulation of signaling#GO:0023051;protein metabolic process#GO:0019538;positive regulation of signaling#GO:0023056 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 HUMAN|HGNC=1309|UniProtKB=Q8WUA7 Q8WUA7 TBC1D22A PTHR22957:SF255 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN TBC1 DOMAIN FAMILY MEMBER 22A enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 protein-binding activity modulator#PC00095;G-protein modulator#PC00022;GTPase-activating protein#PC00257 HUMAN|HGNC=12181|UniProtKB=A0A584 A0A584 TRBV11-2 PTHR23268:SF118 T-CELL RECEPTOR BETA CHAIN T CELL RECEPTOR BETA VARIABLE 11-2 cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=28297|UniProtKB=Q8WV15 Q8WV15 TMEM255B PTHR33721:SF3 TRANSMEMBRANE PROTEIN 255B-LIKE TRANSMEMBRANE PROTEIN 255B HUMAN|HGNC=20768|UniProtKB=Q9BQE3 Q9BQE3 TUBA1C PTHR11588:SF298 TUBULIN TUBULIN ALPHA-1C CHAIN guanyl nucleotide binding#GO:0019001;binding#GO:0005488;structural constituent of cytoskeleton#GO:0005200;nucleoside phosphate binding#GO:1901265;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;ribonucleotide binding#GO:0032553;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;small molecule binding#GO:0036094;anion binding#GO:0043168;ion binding#GO:0043167;nucleotide binding#GO:0000166;structural molecule activity#GO:0005198 cell cycle#GO:0007049;cellular component organization#GO:0016043;mitotic cell cycle#GO:0000278;cell differentiation#GO:0030154;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;microtubule cytoskeleton organization#GO:0000226;anatomical structure development#GO:0048856;system development#GO:0048731;organelle organization#GO:0006996;cellular process#GO:0009987;multicellular organismal process#GO:0032501;cytoskeleton organization#GO:0007010;nervous system development#GO:0007399;neuron differentiation#GO:0030182;developmental process#GO:0032502;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;microtubule-based process#GO:0007017 supramolecular complex#GO:0099080;organelle#GO:0043226;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630;microtubule#GO:0005874;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 tubulin#PC00228;cytoskeletal protein#PC00085 Gonadotropin-releasing hormone receptor pathway#P06664>Tubulin#P06772 HUMAN|HGNC=9101|UniProtKB=P51805 P51805 PLXNA3 PTHR22625:SF32 PLEXIN PLEXIN-A3 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 regulation of biological quality#GO:0065008;axonogenesis#GO:0007409;neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;cell morphogenesis#GO:0000902;synapse assembly#GO:0007416;cell development#GO:0048468;cell junction assembly#GO:0034329;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;regulation of cell shape#GO:0008360;positive regulation of multicellular organismal process#GO:0051240;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;regulation of anatomical structure morphogenesis#GO:0022603;neuron differentiation#GO:0030182;positive regulation of cell differentiation#GO:0045597;positive regulation of cell development#GO:0010720;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;cellular component biogenesis#GO:0044085;neuron projection development#GO:0031175;signal transduction#GO:0007165;regulation of neuron projection development#GO:0010975;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;anatomical structure development#GO:0048856;synapse organization#GO:0050808;positive regulation of cell projection organization#GO:0031346;regulation of cellular process#GO:0050794;cell junction organization#GO:0034330;regulation of neurogenesis#GO:0050767;cellular response to stimulus#GO:0051716;regulation of plasma membrane bounded cell projection organization#GO:0120035;neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;regulation of cell projection organization#GO:0031344;negative regulation of cellular process#GO:0048523;positive regulation of developmental process#GO:0051094;regulation of cell migration#GO:0030334;neuron projection morphogenesis#GO:0048812;regulation of cell differentiation#GO:0045595;multicellular organismal process#GO:0032501;regulation of cell adhesion#GO:0030155;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;axon guidance#GO:0007411;positive regulation of cellular process#GO:0048522;regulation of cell development#GO:0060284;positive regulation of axonogenesis#GO:0050772;generation of neurons#GO:0048699;positive regulation of cellular component organization#GO:0051130;cell projection organization#GO:0030030;cell differentiation#GO:0030154;positive regulation of nervous system development#GO:0051962;signaling#GO:0023052;motor neuron axon guidance#GO:0008045;cellular component organization#GO:0016043;regulation of multicellular organismal development#GO:2000026;cell projection morphogenesis#GO:0048858;regulation of axonogenesis#GO:0050770;cell surface receptor signaling pathway#GO:0007166;plasma membrane bounded cell projection morphogenesis#GO:0120039;cellular component assembly#GO:0022607;regulation of multicellular organismal process#GO:0051239;regulation of cell motility#GO:2000145;cell communication#GO:0007154;regulation of nervous system development#GO:0051960;system development#GO:0048731;regulation of developmental process#GO:0050793;positive regulation of neurogenesis#GO:0050769;cellular developmental process#GO:0048869;developmental process#GO:0032502;negative regulation of cell adhesion#GO:0007162;plasma membrane bounded cell projection organization#GO:0120036;axon development#GO:0061564 plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;signaling receptor complex#GO:0043235;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=3473|UniProtKB=O95718 O95718 ESRRB PTHR48092:SF7 KNIRPS-RELATED PROTEIN-RELATED STEROID HORMONE RECEPTOR ERR2 molecular transducer activity#GO:0060089;cis-regulatory region sequence-specific DNA binding#GO:0000987;nuclear receptor activity#GO:0004879;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulatory region nucleic acid binding#GO:0001067;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C4 zinc finger nuclear receptor#PC00169;zinc finger transcription factor#PC00244 HUMAN|HGNC=1497|UniProtKB=O14936 O14936 CASK PTHR23122:SF40 MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK PERIPHERAL PLASMA MEMBRANE PROTEIN CASK binding#GO:0005488;signaling receptor binding#GO:0005102;protein binding#GO:0005515 intracellular protein localization#GO:0008104;regulation of localization#GO:0032879;regulation of transport#GO:0051049;macromolecule localization#GO:0033036;regulation of trans-synaptic signaling#GO:0099177;biological regulation#GO:0065007;regulation of neurotransmitter transport#GO:0051588;regulation of signaling#GO:0023051;regulation of secretion#GO:0051046;localization#GO:0051179;regulation of secretion by cell#GO:1903530;regulation of biological process#GO:0050789;regulation of neurotransmitter secretion#GO:0046928;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;modulation of chemical synaptic transmission#GO:0050804 basal plasma membrane#GO:0009925;cell periphery#GO:0071944;basolateral plasma membrane#GO:0016323;basal part of cell#GO:0045178;membrane#GO:0016020;cell-cell junction#GO:0005911;plasma membrane#GO:0005886;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;anchoring junction#GO:0070161;cell junction#GO:0030054 scaffold/adaptor protein#PC00226 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CaMK#P00847;Parkinson disease#P00049>CASK#P01232 HUMAN|HGNC=28311|UniProtKB=Q9BW72 Q9BW72 HIGD2A PTHR12297:SF11 HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED HIG1 DOMAIN FAMILY MEMBER 2A, MITOCHONDRIAL mitochondrion organization#GO:0007005;mitochondrial respiratory chain complex assembly#GO:0033108;cellular component assembly#GO:0022607;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739 scaffold/adaptor protein#PC00226 HUMAN|HGNC=20580|UniProtKB=Q6VVX0 Q6VVX0 CYP2R1 PTHR24300:SF48 CYTOCHROME P450 508A4-RELATED VITAMIN D 25-HYDROXYLASE binding#GO:0005488;steroid hydroxylase activity#GO:0008395;tetrapyrrole binding#GO:0046906;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;heme binding#GO:0020037;catalytic activity#GO:0003824;monooxygenase activity#GO:0004497;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen#GO:0016712 lipid metabolic process#GO:0006629;metabolic process#GO:0008152;cellular response to chemical stimulus#GO:0070887;response to xenobiotic stimulus#GO:0009410;vitamin D metabolic process#GO:0042359;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;primary metabolic process#GO:0044238;steroid metabolic process#GO:0008202;xenobiotic metabolic process#GO:0006805;cellular response to xenobiotic stimulus#GO:0071466;response to chemical#GO:0042221;response to stimulus#GO:0050896 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 oxygenase#PC00177;oxidoreductase#PC00176 HUMAN|HGNC=30621|UniProtKB=Q9H2V7 Q9H2V7 SPNS1 PTHR23505:SF13 SPINSTER PROTEIN SPINSTER HOMOLOG 1 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 lipid localization#GO:0010876;transport#GO:0006810;establishment of localization#GO:0051234;localization#GO:0051179;macromolecule localization#GO:0033036;carbohydrate derivative transport#GO:1901264;organophosphate ester transport#GO:0015748;lipid transport#GO:0006869;phospholipid transport#GO:0015914 cellular anatomical structure#GO:0110165;membrane#GO:0016020 transporter#PC00227 HUMAN|HGNC=8668|UniProtKB=Q9Y5H9 Q9Y5H9 PCDHA2 PTHR24028:SF60 CADHERIN-87A PROTOCADHERIN ALPHA-2 cell adhesion#GO:0007155;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cadherin#PC00057;cell adhesion molecule#PC00069 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HUMAN|HGNC=9005|UniProtKB=Q99697 Q99697 PITX2 PTHR45882:SF4 PITUITARY HOMEOBOX HOMOLOG PTX1 PITUITARY HOMEOBOX 2 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987 regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 Gonadotropin-releasing hormone receptor pathway#P06664>PITX#P06722 HUMAN|HGNC=9608|UniProtKB=Q03431 Q03431 PTH1R PTHR45620:SF27 PDF RECEPTOR-LIKE PROTEIN-RELATED PARATHYROID HORMONE_PARATHYROID HORMONE-RELATED PEPTIDE RECEPTOR transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;binding#GO:0005488;molecular transducer activity#GO:0060089;protein binding#GO:0005515;identical protein binding#GO:0042802;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653 cell communication#GO:0007154;inorganic ion homeostasis#GO:0098771;G protein-coupled receptor signaling pathway#GO:0007186;calcium ion homeostasis#GO:0055074;homeostatic process#GO:0042592;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;intracellular monoatomic ion homeostasis#GO:0006873;intracellular calcium ion homeostasis#GO:0006874;system process#GO:0003008;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;renal absorption#GO:0070293;intracellular monoatomic cation homeostasis#GO:0030003;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;signal transduction#GO:0007165;renal system process#GO:0003014;cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=3685|UniProtKB=P21781 P21781 FGF7 PTHR11486:SF20 FIBROBLAST GROWTH FACTOR FIBROBLAST GROWTH FACTOR 7 signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515;molecular function activator activity#GO:0140677;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;growth factor activity#GO:0008083;growth factor receptor binding#GO:0070851;fibroblast growth factor receptor binding#GO:0005104;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772 positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;response to growth factor#GO:0070848;regulation of cell communication#GO:0010646;positive regulation of epithelial cell proliferation#GO:0050679;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of cell motility#GO:2000145;regulation of cell population proliferation#GO:0042127;cell communication#GO:0007154;system development#GO:0048731;positive regulation of cellular process#GO:0048522;multicellular organismal process#GO:0032501;fibroblast growth factor receptor signaling pathway#GO:0008543;positive regulation of response to stimulus#GO:0048584;tube development#GO:0035295;regulation of locomotion#GO:0040012;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;response to fibroblast growth factor#GO:0071774;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;developmental process#GO:0032502;regulation of cell migration#GO:0030334;positive regulation of MAPK cascade#GO:0043410;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;positive regulation of cell population proliferation#GO:0008284;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;cell differentiation#GO:0030154;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;signaling#GO:0023052;regulation of intracellular signal transduction#GO:1902531;animal gross anatomical part developmental process#GO:0160108;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;cellular response to growth factor stimulus#GO:0071363;cellular response to fibroblast growth factor stimulus#GO:0044344;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;nervous system development#GO:0007399;cell surface receptor signaling pathway#GO:0007166;regulation of MAPK cascade#GO:0043408;animal organ development#GO:0048513;multicellular organism development#GO:0007275 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;extracellular region#GO:0005576 intercellular signal molecule#PC00207;growth factor#PC00112 Fructose galactose metabolism#P02744>Galactokinase#P02960;FGF signaling pathway#P00021>FGF#P00623 HUMAN|HGNC=27413|UniProtKB=A2AJT9 A2AJT9 BCLAF3 PTHR15268:SF17 THRAP3/BCLAF1 BCLAF1 AND THRAP3 FAMILY MEMBER 3 DNA binding#GO:0003677;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;nucleic acid binding#GO:0003676;binding#GO:0005488 positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254 nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mediator complex#GO:0016592;intracellular organelle#GO:0043229;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 DNA metabolism protein#PC00009 HUMAN|HGNC=17198|UniProtKB=Q86X52 Q86X52 CHSY1 PTHR12369:SF42 CHONDROITIN SYNTHASE CHONDROITIN SULFATE SYNTHASE 1 acetylgalactosaminyltransferase activity#GO:0008376;glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194;hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740;glucuronosyltransferase activity#GO:0015020 primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;glycoprotein biosynthetic process#GO:0009101;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein O-linked glycosylation#GO:0006493;chondroitin sulfate proteoglycan metabolic process#GO:0050654;carbohydrate derivative metabolic process#GO:1901135;chondroitin sulfate proteoglycan biosynthetic process#GO:0050650;biosynthetic process#GO:0009058;proteoglycan biosynthetic process#GO:0030166;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;proteoglycan metabolic process#GO:0006029 glycosyltransferase#PC00111 HUMAN|HGNC=25758|UniProtKB=Q8TED0 Q8TED0 UTP15 PTHR19924:SF26 UTP15 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 FAMILY MEMBER U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 HOMOLOG ribonucleoprotein complex biogenesis#GO:0022613;regulation of biological process#GO:0050789;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;RNA processing#GO:0006396;positive regulation of macromolecule metabolic process#GO:0010604;gene expression#GO:0010467;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA biosynthetic process#GO:0032774;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;rRNA processing#GO:0006364;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;regulation of transcription by RNA polymerase I#GO:0006356;positive regulation of transcription by RNA polymerase I#GO:0045943;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;regulation of RNA biosynthetic process#GO:2001141;biosynthetic process#GO:0009058;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;macromolecule biosynthetic process#GO:0009059;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;rRNA metabolic process#GO:0016072 intracellular organelle#GO:0043229;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981 RNA metabolism protein#PC00031;RNA processing factor#PC00147 HUMAN|HGNC=5655|UniProtKB=A0A0C4DH41 A0A0C4DH41 IGHV4-61 PTHR23266:SF323 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 4-30-2-RELATED binding#GO:0005488;antigen binding#GO:0003823 immune system process#GO:0002376;immune effector process#GO:0002252;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;immune response#GO:0006955;response to stimulus#GO:0050896;adaptive immune response#GO:0002250 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=45|UniProtKB=P21439 P21439 ABCB4 PTHR24221:SF241 ATP-BINDING CASSETTE SUB-FAMILY B PHOSPHATIDYLCHOLINE TRANSLOCATOR ABCB4 transporter activity#GO:0005215;ATPase-coupled intramembrane lipid carrier activity#GO:0140326;transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657;molecular carrier activity#GO:0140104;phosphatidylcholine intramembrane carrier activity#GO:0008525;lipid carrier activity#GO:0005319;intramembrane lipid carrier activity#GO:0140303 lipid localization#GO:0010876;transmembrane transport#GO:0055085;localization#GO:0051179;regulation of biological quality#GO:0065008;cellular component organization#GO:0016043;organophosphate ester transport#GO:0015748;lipid translocation#GO:0034204;transport#GO:0006810;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;regulation of membrane lipid distribution#GO:0097035;macromolecule localization#GO:0033036;cellular process#GO:0009987;lipid transport#GO:0006869;membrane organization#GO:0061024;biological regulation#GO:0065007;phospholipid transport#GO:0015914;phospholipid translocation#GO:0045332 plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;apical plasma membrane#GO:0016324;membrane#GO:0016020;apical part of cell#GO:0045177;cell periphery#GO:0071944 ATP-binding cassette (ABC) transporter#PC00003 HUMAN|HGNC=6359|UniProtKB=Q9UBX7 Q9UBX7 KLK11 PTHR24271:SF68 KALLIKREIN-RELATED KALLIKREIN-11 catalytic activity#GO:0003824;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;serine-type peptidase activity#GO:0008236;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 extracellular region#GO:0005576;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;vesicle#GO:0031982;secretory vesicle#GO:0099503;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226 serine protease#PC00203 HUMAN|HGNC=6646|UniProtKB=Q8WWI1 Q8WWI1 LMO7 PTHR46767:SF1 LIM DOMAIN ONLY PROTEIN 7 LIM DOMAIN ONLY PROTEIN 7 HUMAN|HGNC=6859|UniProtKB=O43318 O43318 MAP3K7 PTHR46716:SF1 MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7 MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7 MAP kinase kinase kinase activity#GO:0004709;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;MAPK cascade#GO:0000165;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;immune system process#GO:0002376;regulation of intracellular signal transduction#GO:1902531;signaling#GO:0023052;regulation of cell communication#GO:0010646;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;positive regulation of canonical NF-kappaB signal transduction#GO:0043123;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124;positive regulation of response to stimulus#GO:0048584;JNK cascade#GO:0007254;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;immune response#GO:0006955;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of canonical NF-kappaB signal transduction#GO:0043122 non-receptor serine/threonine protein kinase#PC00167 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>MEK#P00864;TGF-beta signaling pathway#P00052>TAK#P01285;Interleukin signaling pathway#P00036>MEK#P00984;Gonadotropin-releasing hormone receptor pathway#P06664>MAP3Ks#P06834;Wnt signaling pathway#P00057>TGFbetaactivated Kinase-1#P01442;Gonadotropin-releasing hormone receptor pathway#P06664>TAK1#P06799;p38 MAPK pathway#P05918>TAK1#P06037;Toll receptor signaling pathway#P00054>TAK1#P01370 HUMAN|HGNC=27609|UniProtKB=Q5UCC4 Q5UCC4 EMC10 PTHR21397:SF6 CHROMATIN COMPLEXES SUBUNIT BAP18-RELATED ER MEMBRANE PROTEIN COMPLEX SUBUNIT 10 molecular carrier activity#GO:0140104;protein carrier activity#GO:0140597;membrane insertase activity#GO:0032977 localization within membrane#GO:0051668;cellular localization#GO:0051641;localization#GO:0051179;protein insertion into ER membrane#GO:0045048;endoplasmic reticulum organization#GO:0007029;cellular component organization#GO:0016043;protein localization to organelle#GO:0033365;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of protein localization to membrane#GO:0090150;organelle organization#GO:0006996;macromolecule localization#GO:0033036;membrane organization#GO:0061024;endomembrane system organization#GO:0010256;tail-anchored membrane protein insertion into ER membrane#GO:0071816;protein insertion into membrane#GO:0051205 endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endoplasmic reticulum protein-containing complex#GO:0140534;organelle membrane#GO:0031090;membrane#GO:0016020;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasm#GO:0005737;EMC complex#GO:0072546;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;membrane protein complex#GO:0098796;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=16816|UniProtKB=Q8TDI0 Q8TDI0 CHD5 PTHR45623:SF6 CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED ATP-DEPENDENT CHROMATIN REMODELER CHD5 hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity, acting on DNA#GO:0140097;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;ATP-dependent activity#GO:0140657;ATP-dependent activity, acting on DNA#GO:0008094;protein binding#GO:0005515;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;pyrophosphatase activity#GO:0016462;histone binding#GO:0042393;ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleic acid binding#GO:0003676;chromatin binding#GO:0003682;DNA binding#GO:0003677;hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887 cellular process#GO:0009987;cellular component organization#GO:0016043;chromatin remodeling#GO:0006338;chromatin organization#GO:0006325;cellular component organization or biogenesis#GO:0071840 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;nucleus#GO:0005634;chromatin#GO:0000785;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=12149|UniProtKB=P01737 P01737 TRAV8-4 PTHR19367:SF24 T-CELL RECEPTOR ALPHA CHAIN V REGION T CELL RECEPTOR ALPHA VARIABLE 8-4 response to stimulus#GO:0050896;adaptive immune response#GO:0002250;immune system process#GO:0002376;immune response#GO:0006955 protein-containing complex#GO:0032991 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=29798|UniProtKB=Q5TCX8 Q5TCX8 MAP3K21 PTHR23257:SF750 SERINE-THREONINE PROTEIN KINASE MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 21 transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=21268|UniProtKB=Q8IZ07 Q8IZ07 ANKRD13A PTHR12447:SF4 ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13 ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13A molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 regulation of transport#GO:0051049;regulation of localization#GO:0032879;regulation of endocytosis#GO:0030100;biological regulation#GO:0065007;regulation of cellular component organization#GO:0051128;regulation of receptor-mediated endocytosis#GO:0048259;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627 membrane#GO:0016020;cell periphery#GO:0071944;late endosome#GO:0005770;endomembrane system#GO:0012505;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HUMAN|HGNC=17233|UniProtKB=Q96JJ3 Q96JJ3 ELMO2 PTHR12771:SF8 ENGULFMENT AND CELL MOTILITY ENGULFMENT AND CELL MOTILITY PROTEIN 2 locomotion#GO:0040011;response to stimulus#GO:0050896;actin cytoskeleton organization#GO:0030036;cell motility#GO:0048870;cellular response to stimulus#GO:0051716;cellular component organization#GO:0016043;cell chemotaxis#GO:0060326;supramolecular fiber organization#GO:0097435;chemotaxis#GO:0006935;actin filament-based process#GO:0030029;cellular response to chemical stimulus#GO:0070887;cytoskeleton organization#GO:0007010;taxis#GO:0042330;response to chemical#GO:0042221;cell migration#GO:0016477;cellular process#GO:0009987;organelle organization#GO:0006996;response to external stimulus#GO:0009605;actin filament organization#GO:0007015;cellular component organization or biogenesis#GO:0071840 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 Integrin signalling pathway#P00034>ELMO#P00917 HUMAN|HGNC=25047|UniProtKB=Q96FV0 Q96FV0 LRRC46 PTHR45973:SF9 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED LEUCINE-RICH REPEAT-CONTAINING PROTEIN 46 protein-binding activity modulator#PC00095;phosphatase modulator#PC00184 HUMAN|HGNC=25573|UniProtKB=Q8IYD2 Q8IYD2 KLHDC8A PTHR46260:SF1 RING-TYPE DOMAIN-CONTAINING PROTEIN KELCH DOMAIN-CONTAINING PROTEIN 8A HUMAN|HGNC=14082|UniProtKB=Q9NQW6 Q9NQW6 ANLN PTHR21538:SF27 ANILLIN/RHOTEKIN RTKN ANILLIN cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;actomyosin contractile ring assembly#GO:0000915;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;mitotic cell cycle process#GO:1903047;septin cytoskeleton organization#GO:0032185;mitotic cell cycle#GO:0000278;mitotic cytokinesis#GO:0000281;actin cytoskeleton organization#GO:0030036;actomyosin structure organization#GO:0031032;cell cycle#GO:0007049;cellular component organization#GO:0016043;cell division#GO:0051301;cell cycle process#GO:0022402;septin ring organization#GO:0031106;cortical actin cytoskeleton organization#GO:0030866;cytoskeleton-dependent cytokinesis#GO:0061640;cortical cytoskeleton organization#GO:0030865;cytokinesis#GO:0000910;cytokinetic process#GO:0032506;actin filament-based process#GO:0030029 cell periphery#GO:0071944;cell division site#GO:0032153;intracellular membraneless organelle#GO:0043232;cortical actin cytoskeleton#GO:0030864;cytoplasm#GO:0005737;contractile ring#GO:0070938;cytoskeleton#GO:0005856;actomyosin contractile ring#GO:0005826;membraneless organelle#GO:0043228;actin cytoskeleton#GO:0015629;cortical cytoskeleton#GO:0030863;cell cortex#GO:0005938;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-motor actin binding protein#PC00165 HUMAN|HGNC=7661|UniProtKB=P19878 P19878 NCF2 PTHR15175:SF3 NEUTROPHIL CYTOSOLIC FACTOR 2, NEUTROPHIL NADPH OXIDASE FACTOR 2 NEUTROPHIL CYTOSOL FACTOR 2 molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;enzyme activator activity#GO:0008047 superoxide metabolic process#GO:0006801;reactive oxygen species metabolic process#GO:0072593;metabolic process#GO:0008152;cellular process#GO:0009987 plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane protein complex#GO:0098796;oxidoreductase complex#GO:1990204;membrane#GO:0016020;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494 protein-binding activity modulator#PC00095 HUMAN|HGNC=7044|UniProtKB=P26572 P26572 MGAT1 PTHR10468:SF12 PROTEIN O-LINKED-MANNOSE BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE 1/ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 2-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 2-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE acetylglucosaminyltransferase activity#GO:0008375;glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194;catalytic activity, acting on a protein#GO:0140096;hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740 carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487;glycoprotein biosynthetic process#GO:0009101;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HUMAN|HGNC=19677|UniProtKB=Q8TBZ2 Q8TBZ2 MYCBPAP PTHR12276:SF123 EPSIN/ENT-RELATED MYCBP-ASSOCIATED PROTEIN clathrin binding#GO:0030276;phospholipid binding#GO:0005543;binding#GO:0005488;protein binding#GO:0005515;lipid binding#GO:0008289 import into cell#GO:0098657;establishment of localization#GO:0051234;localization#GO:0051179;receptor-mediated endocytosis#GO:0006898;transport#GO:0006810;vesicle-mediated transport#GO:0016192;endocytosis#GO:0006897;clathrin-dependent endocytosis#GO:0072583;cellular process#GO:0009987 vesicle#GO:0031982;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;coated vesicle membrane#GO:0030662;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;clathrin coat#GO:0030118;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;coated vesicle#GO:0030135;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;coated membrane#GO:0048475;membrane coat#GO:0030117;cell periphery#GO:0071944;vesicle membrane#GO:0012506;membrane#GO:0016020;plasma membrane#GO:0005886;vesicle coat#GO:0030120;cytoplasm#GO:0005737;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;clathrin vesicle coat#GO:0030125;clathrin-coated vesicle#GO:0030136;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;clathrin-coated vesicle membrane#GO:0030665 membrane trafficking regulatory protein#PC00151;membrane traffic protein#PC00150 HUMAN|HGNC=9595|UniProtKB=P43115 P43115 PTGER3 PTHR11866:SF10 G-PROTEIN COUPLED RECEPTOR FAMILY 1 MEMBER PROSTAGLANDIN E2 RECEPTOR EP3 SUBTYPE transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930 positive regulation of cytosolic calcium ion concentration#GO:0007204;G protein-coupled receptor signaling pathway#GO:0007186;phospholipase C-activating G protein-coupled receptor signaling pathway#GO:0007200;inflammatory response#GO:0006954;cell communication#GO:0007154;regulation of secretion#GO:0051046;regulation of biological quality#GO:0065008;negative regulation of multicellular organismal process#GO:0051241;negative regulation of biological process#GO:0048519;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;muscle system process#GO:0003012;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;negative regulation of transport#GO:0051051;signaling#GO:0023052;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;regulation of system process#GO:0044057;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;muscle contraction#GO:0006936;defense response#GO:0006952;system process#GO:0003008;regulation of localization#GO:0032879;regulation of transport#GO:0051049;response to stress#GO:0006950;cellular process#GO:0009987;signal transduction#GO:0007165;multicellular organismal process#GO:0032501;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 Gonadotropin-releasing hormone receptor pathway#P06664>PG Rcs#P06836;PI3 kinase pathway#P00048>GPCR#P01204 HUMAN|HGNC=7456|UniProtKB=P03891 P03891 MT-ND2 PTHR46552:SF1 NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 2 NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 2 oxidoreductase activity, acting on NAD(P)H#GO:0016651;monoatomic cation transmembrane transporter activity#GO:0008324;electron transfer activity#GO:0009055;NADH dehydrogenase activity#GO:0003954;oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor#GO:0016655;active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399;monoatomic ion transmembrane transporter activity#GO:0015075;oxidoreductase activity#GO:0016491;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;catalytic activity#GO:0003824;proton transmembrane transporter activity#GO:0015078 metabolic process#GO:0008152;aerobic electron transport chain#GO:0019646;generation of precursor metabolites and energy#GO:0006091;mitochondrial electron transport, NADH to ubiquinone#GO:0006120;ATP synthesis coupled electron transport#GO:0042773;oxidative phosphorylation#GO:0006119;cellular respiration#GO:0045333;energy derivation by oxidation of organic compounds#GO:0015980;aerobic respiration#GO:0009060;electron transport chain#GO:0022900;mitochondrial ATP synthesis coupled electron transport#GO:0042775;respiratory electron transport chain#GO:0022904;cellular process#GO:0009987 transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;catalytic complex#GO:1902494;respiratory chain complex I#GO:0045271;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;respiratory chain complex#GO:0098803;membrane protein complex#GO:0098796;oxidoreductase complex#GO:1990204;membrane#GO:0016020 oxidoreductase#PC00176 HUMAN|HGNC=31287|UniProtKB=A6NDH6 A6NDH6 OR5H15 PTHR26452:SF135 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5H15 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 sensory perception of chemical stimulus#GO:0007606;nervous system process#GO:0050877;sensory perception#GO:0007600;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;system process#GO:0003008 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=11334|UniProtKB=P35346 P35346 SSTR5 PTHR24229:SF20 NEUROPEPTIDES RECEPTOR SOMATOSTATIN RECEPTOR TYPE 5 molecular transducer activity#GO:0060089;binding#GO:0005488;neuropeptide receptor activity#GO:0008188;transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;neuropeptide binding#GO:0042923;peptide binding#GO:0042277;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;signaling receptor activity#GO:0038023 biological regulation#GO:0065007;response to steroid hormone#GO:0048545;regulation of establishment of protein localization#GO:0070201;cell communication#GO:0007154;regulation of secretion#GO:0051046;cellular response to stimulus#GO:0051716;regulation of protein secretion#GO:0050708;neuropeptide signaling pathway#GO:0007218;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of localization#GO:0032879;regulation of transport#GO:0051049;cellular response to steroid hormone stimulus#GO:0071383;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of insulin secretion#GO:0050796;response to hormone#GO:0009725;response to chemical#GO:0042221;response to lipid#GO:0033993;cellular response to lipid#GO:0071396;regulation of signaling#GO:0023051;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;regulation of protein localization#GO:0032880;regulation of secretion by cell#GO:1903530;regulation of biological quality#GO:0065008;regulation of hormone secretion#GO:0046883;regulation of biological process#GO:0050789;regulation of hormone levels#GO:0010817;response to endogenous stimulus#GO:0009719;signaling#GO:0023052;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;cellular response to hormone stimulus#GO:0032870;regulation of protein transport#GO:0051223 membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005;cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;cell projection#GO:0042995 G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GsPCR#P00720;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GoPCR#P00725;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711 HUMAN|HGNC=30670|UniProtKB=Q496J9 Q496J9 SV2C PTHR23511:SF6 SYNAPTIC VESICLE GLYCOPROTEIN 2 SYNAPTIC VESICLE GLYCOPROTEIN 2C regulation of neurotransmitter secretion#GO:0046928;regulation of cellular process#GO:0050794;modulation of chemical synaptic transmission#GO:0050804;regulation of synaptic vesicle exocytosis#GO:2000300;regulation of cell communication#GO:0010646;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;regulation of secretion#GO:0051046;regulation of secretion by cell#GO:1903530;regulation of exocytosis#GO:0017157;regulation of neurotransmitter transport#GO:0051588;regulation of signaling#GO:0023051;regulation of trans-synaptic signaling#GO:0099177;biological regulation#GO:0065007;regulation of localization#GO:0032879;regulation of transport#GO:0051049 bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;cell junction#GO:0030054;presynapse#GO:0098793;secretory vesicle#GO:0099503;membrane#GO:0016020;vesicle membrane#GO:0012506;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;transport vesicle membrane#GO:0030658;endomembrane system#GO:0012505;transport vesicle#GO:0030133;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;synaptic vesicle#GO:0008021;vesicle#GO:0031982;synaptic vesicle membrane#GO:0030672;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=8297|UniProtKB=Q8NGC2 Q8NGC2 OR4E2 PTHR26451:SF160 G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN OLFACTORY RECEPTOR 4E2 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 response to chemical#GO:0042221;response to stimulus#GO:0050896;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;detection of chemical stimulus#GO:0009593;system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception#GO:0007600;nervous system process#GO:0050877 cellular anatomical structure#GO:0110165;membrane#GO:0016020 G-protein coupled receptor#PC00021 HUMAN|HGNC=30771|UniProtKB=Q8IYF1 Q8IYF1 ELOA2 PTHR15141:SF7 TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3 ELONGIN-A2 nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;transcription by RNA polymerase II#GO:0006366;macromolecule metabolic process#GO:0043170;DNA-templated transcription elongation#GO:0006354;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;transcription elongation by RNA polymerase II#GO:0006368;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058 organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nuclear lumen#GO:0031981;transcription elongation factor complex#GO:0008023;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 general transcription factor#PC00259 HUMAN|HGNC=19118|UniProtKB=Q8NFZ5 Q8NFZ5 TNIP2 PTHR31882:SF14 TNFAIP3-INTERACTING PROTEIN COILED COIL FAMILY MEMBER TNFAIP3-INTERACTING PROTEIN 2 regulation of signal transduction#GO:0009966;regulation of RNA biosynthetic process#GO:2001141;response to other organism#GO:0051707;positive regulation of innate immune response#GO:0045089;activation of innate immune response#GO:0002218;regulation of macromolecule biosynthetic process#GO:0010556;response to external stimulus#GO:0009605;regulation of gene expression#GO:0010468;cellular response to molecule of bacterial origin#GO:0071219;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stress#GO:0080134;response to external biotic stimulus#GO:0043207;immune response-activating cell surface receptor signaling pathway#GO:0002429;regulation of response to biotic stimulus#GO:0002831;positive regulation of cell communication#GO:0010647;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;regulation of DNA-templated transcription#GO:0006355;response to bacterium#GO:0009617;response to chemical#GO:0042221;response to lipid#GO:0033993;cellular response to lipopolysaccharide#GO:0071222;positive regulation of response to external stimulus#GO:0032103;positive regulation of canonical NF-kappaB signal transduction#GO:0043123;cell surface receptor signaling pathway#GO:0007166;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;positive regulation of signaling#GO:0023056;response to oxygen-containing compound#GO:1901700;regulation of intracellular signal transduction#GO:1902531;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of response to stimulus#GO:0048584;positive regulation of cellular process#GO:0048522;regulation of canonical NF-kappaB signal transduction#GO:0043122;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;positive regulation of response to biotic stimulus#GO:0002833;pattern recognition receptor signaling pathway#GO:0002221;regulation of innate immune response#GO:0045088;regulation of biosynthetic process#GO:0009889;positive regulation of immune response#GO:0050778;positive regulation of defense response#GO:0031349;regulation of response to stimulus#GO:0048583;intracellular receptor signaling pathway#GO:0030522;regulation of cell communication#GO:0010646;regulation of macromolecule metabolic process#GO:0060255;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;innate immune response-activating signaling pathway#GO:0002758;cellular response to biotic stimulus#GO:0071216;regulation of RNA metabolic process#GO:0051252;regulation of immune response#GO:0050776;regulation of defense response#GO:0031347;regulation of response to external stimulus#GO:0032101;cellular response to lipid#GO:0071396;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987;response to biotic stimulus#GO:0009607;positive regulation of immune system process#GO:0002684;response to lipopolysaccharide#GO:0032496;immune response-activating signaling pathway#GO:0002757;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;response to molecule of bacterial origin#GO:0002237;immune response-regulating signaling pathway#GO:0002764;cytoplasmic pattern recognition receptor signaling pathway#GO:0002753;regulation of signaling#GO:0023051;immune system process#GO:0002376;cellular response to chemical stimulus#GO:0070887 HUMAN|HGNC=30652|UniProtKB=Q8WXE9 Q8WXE9 STON2 PTHR10529:SF345 AP COMPLEX SUBUNIT MU STONIN-2 cargo adaptor activity#GO:0140312;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 synaptic vesicle endocytosis#GO:0048488;regulation of biological process#GO:0050789;clathrin-dependent endocytosis#GO:0072583;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;endocytosis#GO:0006897;localization#GO:0051179;Golgi to vacuole transport#GO:0006896;cellular localization#GO:0051641;post-Golgi vesicle-mediated transport#GO:0006892;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;synaptic vesicle recycling#GO:0036465;vesicle-mediated transport#GO:0016192;biological regulation#GO:0065007;intracellular transport#GO:0046907;vacuolar transport#GO:0007034;regulation of endocytosis#GO:0030100;transport#GO:0006810;synaptic vesicle cycle#GO:0099504;Golgi vesicle transport#GO:0048193;import into cell#GO:0098657;vesicle-mediated transport in synapse#GO:0099003;establishment of localization#GO:0051234;regulation of transport#GO:0051049;receptor-mediated endocytosis#GO:0006898;regulation of localization#GO:0032879 coated vesicle membrane#GO:0030662;organelle#GO:0043226;cellular anatomical structure#GO:0110165;clathrin coat#GO:0030118;synapse#GO:0045202;intracellular vesicle#GO:0097708;clathrin-coated pit#GO:0005905;organelle subcompartment#GO:0031984;endocytic vesicle#GO:0030139;coated vesicle#GO:0030135;coated membrane#GO:0048475;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;vesicle coat#GO:0030120;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;presynapse#GO:0098793;secretory vesicle#GO:0099503;AP-type membrane coat adaptor complex#GO:0030119;bounding membrane of organelle#GO:0098588;cell junction#GO:0030054;clathrin-coated vesicle membrane#GO:0030665;clathrin-coated endocytic vesicle#GO:0045334;clathrin vesicle coat#GO:0030125;intracellular membrane-bounded organelle#GO:0043231;vesicle#GO:0031982;plasma membrane protein complex#GO:0098797;synaptic vesicle#GO:0008021;membrane protein complex#GO:0098796;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane coat#GO:0030117;plasma membrane#GO:0005886;transport vesicle#GO:0030133;endomembrane system#GO:0012505;cell periphery#GO:0071944;vesicle membrane#GO:0012506;cytosol#GO:0005829;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;organelle membrane#GO:0031090;Golgi apparatus#GO:0005794;clathrin-coated vesicle#GO:0030136 membrane traffic protein#PC00150 HUMAN|HGNC=7038|UniProtKB=O00587 O00587 MFNG PTHR10811:SF6 FRINGE-RELATED BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE MANIC FRINGE transferase activity#GO:0016740;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;acetylglucosaminyltransferase activity#GO:0008375 regulation of biological process#GO:0050789;regulation of cell communication#GO:0010646;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;regulation of Notch signaling pathway#GO:0008593 transferase#PC00220;glycosyltransferase#PC00111 Notch signaling pathway#P00045>Fringe#P01107 HUMAN|HGNC=30401|UniProtKB=Q8WVC0 Q8WVC0 LEO1 PTHR23146:SF0 LEO1 PROTEIN RNA POLYMERASE-ASSOCIATED PROTEIN LEO1 transcription coregulator activity#GO:0003712;RNA polymerase binding#GO:0070063;RNA polymerase core enzyme binding#GO:0043175;binding#GO:0005488;enzyme binding#GO:0019899;transcription regulator activity#GO:0140110;RNA polymerase II complex binding#GO:0000993;protein binding#GO:0005515 RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;transcription elongation by RNA polymerase II#GO:0006368;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;DNA-templated transcription elongation#GO:0006354;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;transcription by RNA polymerase II#GO:0006366 organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;transcription elongation factor complex#GO:0008023;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;RNA polymerase II, holoenzyme#GO:0016591;membrane-bounded organelle#GO:0043227;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;membrane-enclosed lumen#GO:0031974;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;Cdc73/Paf1 complex#GO:0016593;transferase complex#GO:1990234 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 HUMAN|HGNC=19997|UniProtKB=Q7Z602 Q7Z602 GPR141 PTHR24237:SF35 G-PROTEIN COUPLED RECEPTOR G PROTEIN-COUPLED RECEPTOR 141-RELATED molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 inflammatory response#GO:0006954;G protein-coupled receptor signaling pathway#GO:0007186;defense response#GO:0006952;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;response to stress#GO:0006950;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021 HUMAN|HGNC=10995|UniProtKB=Q6PCB7 Q6PCB7 SLC27A1 PTHR43107:SF7 LONG-CHAIN FATTY ACID TRANSPORT PROTEIN LONG-CHAIN FATTY ACID TRANSPORT PROTEIN 1 catalytic activity#GO:0003824;ligase activity#GO:0016874;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monocarboxylic acid transmembrane transporter activity#GO:0008028;ligase activity, forming carbon-sulfur bonds#GO:0016877;ATP-dependent activity#GO:0140657;carboxylic acid transmembrane transporter activity#GO:0046943 primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;small molecule metabolic process#GO:0044281;oxoacid metabolic process#GO:0043436;lipid localization#GO:0010876;localization#GO:0051179;fatty acid transport#GO:0015908;monocarboxylic acid transport#GO:0015718;long-chain fatty acid metabolic process#GO:0001676;macromolecule localization#GO:0033036;cellular process#GO:0009987;lipid transport#GO:0006869;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;carboxylic acid transport#GO:0046942;lipid metabolic process#GO:0006629;transport#GO:0006810;organic acid transport#GO:0015849;establishment of localization#GO:0051234;import into cell#GO:0098657 endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;endomembrane system#GO:0012505 secondary carrier transporter#PC00258 HUMAN|HGNC=13536|UniProtKB=Q8TF62 Q8TF62 ATP8B4 PTHR24092:SF80 PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE PHOSPHOLIPID-TRANSPORTING ATPASE IM-RELATED intramembrane lipid carrier activity#GO:0140303;molecular carrier activity#GO:0140104;lipid carrier activity#GO:0005319;ATP-dependent activity#GO:0140657;transporter activity#GO:0005215;ATPase-coupled intramembrane lipid carrier activity#GO:0140326 transport#GO:0006810;regulation of membrane lipid distribution#GO:0097035;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;cellular process#GO:0009987;macromolecule localization#GO:0033036;organelle organization#GO:0006996;phospholipid transport#GO:0015914;biological regulation#GO:0065007;phospholipid translocation#GO:0045332;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;lipid transport#GO:0006869;lipid localization#GO:0010876;regulation of biological quality#GO:0065008;localization#GO:0051179;Golgi organization#GO:0007030;cellular component organization#GO:0016043;lipid translocation#GO:0034204;organophosphate ester transport#GO:0015748 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;plasma membrane#GO:0005886;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;cell periphery#GO:0071944;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 transporter#PC00227;primary active transporter#PC00068 HUMAN|HGNC=28672|UniProtKB=Q9BQA9 Q9BQA9 CYBC1 PTHR31837:SF3 CYTOCHROME B-245 CHAPERONE 1 CYTOCHROME B-245 CHAPERONE 1 response to other organism#GO:0051707;defense response to other organism#GO:0098542;cellular process#GO:0009987;defense response to symbiont#GO:0140546;immune response#GO:0006955;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;defense response#GO:0006952;response to external stimulus#GO:0009605;innate immune response#GO:0045087;immune effector process#GO:0002252;metabolic process#GO:0008152;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to stimulus#GO:0050896;immune system process#GO:0002376 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 chaperone#PC00072 HUMAN|HGNC=18503|UniProtKB=Q9BYV7 Q9BYV7 BCO2 PTHR10543:SF122 BETA-CAROTENE DIOXYGENASE CAROTENOID-CLEAVING DIOXYGENASE, MITOCHONDRIAL oxidoreductase activity#GO:0016491;dioxygenase activity#GO:0051213;oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen#GO:0016702;catalytic activity#GO:0003824 cellular process#GO:0009987;aldehyde metabolic process#GO:0006081;lipid catabolic process#GO:0016042;primary metabolic process#GO:0044238;catabolic process#GO:0009056;lipid metabolic process#GO:0006629;terpenoid metabolic process#GO:0006721;olefinic compound metabolic process#GO:0120254;metabolic process#GO:0008152;diterpenoid metabolic process#GO:0016101;isoprenoid metabolic process#GO:0006720;retinoid metabolic process#GO:0001523 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 oxygenase#PC00177;oxidoreductase#PC00176 HUMAN|HGNC=29636|UniProtKB=Q8NEH6 Q8NEH6 MNS1 PTHR19265:SF0 MEIOSIS-SPECIFIC NUCLEAR STRUCTURAL PROTEIN 1 MEIOSIS-SPECIFIC NUCLEAR STRUCTURAL PROTEIN 1 cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;cilium organization#GO:0044782;plasma membrane bounded cell projection organization#GO:0120036;cell projection organization#GO:0030030;cellular component organization or biogenesis#GO:0071840 cilium#GO:0005929;motile cilium#GO:0031514;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025 structural protein#PC00211 HUMAN|HGNC=18002|UniProtKB=Q9NS69 Q9NS69 TOMM22 PTHR12504:SF3 MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22 MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22 HOMOLOG intracellular transport#GO:0046907;protein transmembrane transport#GO:0071806;transport#GO:0006810;intracellular protein transport#GO:0006886;protein transmembrane import into intracellular organelle#GO:0044743;intracellular protein transmembrane transport#GO:0065002;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;protein import into mitochondrial matrix#GO:0030150;mitochondrial protein import pathway#GO:7770058;mitochondrial transmembrane transport#GO:1990542;transmembrane transport#GO:0055085;cellular localization#GO:0051641;localization#GO:0051179;protein transport#GO:0015031;protein localization to mitochondrion#GO:0070585;protein localization to organelle#GO:0033365;mitochondrial transport#GO:0006839 intracellular organelle#GO:0043229;outer membrane#GO:0019867;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle envelope#GO:0031967;membrane protein complex#GO:0098796;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;mitochondrial outer membrane translocase complex#GO:0005742;mitochondrial outer membrane#GO:0005741;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane#GO:0016020;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;organelle outer membrane#GO:0031968;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;cytoplasm#GO:0005737 primary active transporter#PC00068;transporter#PC00227 HUMAN|HGNC=9093|UniProtKB=P55058 P55058 PLTP PTHR10504:SF16 BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED PHOSPHOLIPID TRANSFER PROTEIN lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104;transporter activity#GO:0005215;phospholipid transfer activity#GO:0120014;lipid transfer activity#GO:0120013 regulation of biological process#GO:0050789;cellular component organization#GO:0016043;ceramide transport#GO:0035627;organophosphate ester transport#GO:0015748;lipid localization#GO:0010876;localization#GO:0051179;cellular process#GO:0009987;nitrogen compound transport#GO:0071705;macromolecule localization#GO:0033036;phospholipid transport#GO:0015914;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;lipid transport#GO:0006869;transport#GO:0006810;protein-containing complex organization#GO:0043933;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090 HUMAN|HGNC=4912|UniProtKB=P49773 P49773 HINT1 PTHR23089:SF45 HISTIDINE TRIAD HIT PROTEIN ADENOSINE 5'-MONOPHOSPHORAMIDASE HINT1 catalytic activity#GO:0003824;hydrolase activity#GO:0016787 nucleobase-containing small molecule metabolic process#GO:0055086;purine-containing compound catabolic process#GO:0072523;metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;nucleotide catabolic process#GO:0009166;nucleobase-containing compound metabolic process#GO:0006139;ribonucleotide catabolic process#GO:0009261;carbohydrate derivative metabolic process#GO:1901135;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;nucleobase-containing compound catabolic process#GO:0034655;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;organophosphate catabolic process#GO:0046434;purine nucleotide catabolic process#GO:0006195;ribonucleotide metabolic process#GO:0009259;carbohydrate derivative catabolic process#GO:1901136;nucleoside phosphate metabolic process#GO:0006753;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;nucleoside phosphate catabolic process#GO:1901292;purine nucleotide metabolic process#GO:0006163;purine ribonucleotide catabolic process#GO:0009154;purine-containing compound metabolic process#GO:0072521;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634 nucleotide phosphatase#PC00173 HUMAN|HGNC=30755|UniProtKB=Q7Z2V1 Q7Z2V1 C16orf82 PTHR40139:SF1 PROTEIN TNT PROTEIN TNT HUMAN|HGNC=2096|UniProtKB=Q15846 Q15846 CLUL1 PTHR10970:SF2 CLUSTERIN CLUSTERIN-LIKE PROTEIN 1 protein binding#GO:0005515;binding#GO:0005488 extracellular region#GO:0005576;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=4883|UniProtKB=P08603 P08603 CFH PTHR45785:SF7 COMPLEMENT FACTOR H-RELATED COMPLEMENT FACTOR H protein binding#GO:0005515;binding#GO:0005488;complement binding#GO:0001848 humoral immune response#GO:0006959;positive regulation of immune response#GO:0050778;immune effector process#GO:0002252;regulation of response to stimulus#GO:0048583;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;positive regulation of immune system process#GO:0002684;activation of immune response#GO:0002253;immune response#GO:0006955;positive regulation of biological process#GO:0048518;complement activation#GO:0006956;immune system process#GO:0002376;regulation of immune response#GO:0050776;response to stimulus#GO:0050896;regulation of immune system process#GO:0002682;regulation of biological process#GO:0050789 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 complement component#PC00078 HUMAN|HGNC=14423|UniProtKB=Q9NYR8 Q9NYR8 RDH8 PTHR43391:SF8 RETINOL DEHYDROGENASE-RELATED RETINOL DEHYDROGENASE 8 alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824;all-trans-retinol dehydrogenase (NAD+) activity#GO:0004745;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;alcohol dehydrogenase (NAD+) activity#GO:0004022 terpenoid metabolic process#GO:0006721;olefinic compound metabolic process#GO:0120254;retinol metabolic process#GO:0042572;regulation of biological quality#GO:0065008;isoprenoid metabolic process#GO:0006720;regulation of hormone levels#GO:0010817;primary metabolic process#GO:0044238;small molecule metabolic process#GO:0044281;lipid metabolic process#GO:0006629;alcohol metabolic process#GO:0006066;metabolic process#GO:0008152;diterpenoid metabolic process#GO:0016101;retinoid metabolic process#GO:0001523;cellular process#GO:0009987;biological regulation#GO:0065007;hormone metabolic process#GO:0042445 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 dehydrogenase#PC00092 HUMAN|HGNC=24009|UniProtKB=Q6UXV4 Q6UXV4 APOOL PTHR14564:SF3 MICOS COMPLEX SUBUNIT MIC26 / MIC27 FAMILY MEMBER MICOS COMPLEX SUBUNIT MIC27 cellular component organization or biogenesis#GO:0071840;organelle organization#GO:0006996;cellular component organization#GO:0016043;mitochondrial membrane organization#GO:0007006;inner mitochondrial membrane organization#GO:0007007;cellular process#GO:0009987;mitochondrion organization#GO:0007005;membrane organization#GO:0061024 inner mitochondrial membrane protein complex#GO:0098800;organelle membrane#GO:0031090;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrial membrane#GO:0031966;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;cytoplasm#GO:0005737;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;organelle envelope#GO:0031967;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=10369|UniProtKB=P32969 P32969 RPL9 PTHR11655:SF46 60S/50S RIBOSOMAL PROTEIN L6/L9 LARGE RIBOSOMAL SUBUNIT PROTEIN UL6 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;cytoplasmic translation#GO:0002181;biosynthetic process#GO:0009058;metabolic process#GO:0008152;translation#GO:0006412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;ribosome#GO:0005840;cytosol#GO:0005829;cytosolic large ribosomal subunit#GO:0022625;cytosolic ribosome#GO:0022626;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 ribosomal protein#PC00202 HUMAN|HGNC=20154|UniProtKB=Q8TB40 Q8TB40 ABHD4 PTHR42886:SF21 RE40534P-RELATED (LYSO)-N-ACYLPHOSPHATIDYLETHANOLAMINE LIPASE hydrolase activity, acting on ester bonds#GO:0016788;phospholipase activity#GO:0120569;glycerophospholipase activity#GO:0004620;catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;carboxylic ester hydrolase activity#GO:0052689;acyltransferase activity#GO:0016746;lipase activity#GO:0016298;phosphatidylcholine lysophospholipase A1 activity#GO:0004622;hydrolase activity#GO:0016787 lipid metabolic process#GO:0006629;chemical homeostasis#GO:0048878;glycerophospholipid biosynthetic process#GO:0046474;metabolic process#GO:0008152;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;glycerophospholipid metabolic process#GO:0006650;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;organophosphate metabolic process#GO:0019637;organophosphate biosynthetic process#GO:0090407;phospholipid metabolic process#GO:0006644;homeostatic process#GO:0042592;phospholipid biosynthetic process#GO:0008654;glycerolipid metabolic process#GO:0046486;lipid homeostasis#GO:0055088;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membraneless organelle#GO:0043228;intracellular membraneless organelle#GO:0043232;lipid droplet#GO:0005811;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=6108|UniProtKB=Q9Y573 Q9Y573 IPP PTHR24412:SF35 KELCH PROTEIN ACTIN-BINDING PROTEIN IPP ubiquitin-like ligase-substrate adaptor activity#GO:1990756;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;enzyme-substrate adaptor activity#GO:0140767 protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056 cullin-RING ubiquitin ligase complex#GO:0031461;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;Cul3-RING ubiquitin ligase complex#GO:0031463;ubiquitin ligase complex#GO:0000151;transferase complex#GO:1990234;catalytic complex#GO:1902494 scaffold/adaptor protein#PC00226 HUMAN|HGNC=30630|UniProtKB=Q96A44 Q96A44 SPSB4 PTHR12245:SF3 SPRY DOMAIN CONTAINING SOCS BOX PROTEIN SPRY DOMAIN-CONTAINING SOCS BOX PROTEIN 4 ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163 cytosol#GO:0005829;cullin-RING ubiquitin ligase complex#GO:0031461;SCF ubiquitin ligase complex#GO:0019005;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;ubiquitin ligase complex#GO:0000151 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=20161|UniProtKB=O94842 O94842 TOX4 PTHR45781:SF2 AGAP000281-PA TOX HIGH MOBILITY GROUP BOX FAMILY MEMBER 4 binding#GO:0005488;nucleic acid binding#GO:0003676;chromatin binding#GO:0003682;chromatin DNA binding#GO:0031490;DNA binding#GO:0003677 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA-binding transcription factor#PC00218;HMG box transcription factor#PC00024 HUMAN|HGNC=5636|UniProtKB=A0A075B7B8 A0A075B7B8 IGHV3OR16-12 PTHR23266:SF384 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 3-53-RELATED binding#GO:0005488;antigen binding#GO:0003823 leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449;immunoglobulin mediated immune response#GO:0016064;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immune system process#GO:0002376;immune effector process#GO:0002252;response to stimulus#GO:0050896;adaptive immune response#GO:0002250;immune response#GO:0006955 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=483|UniProtKB=P03950 P03950 ANG PTHR11437:SF60 RIBONUCLEASE ANGIOGENIN catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;RNA nuclease activity#GO:0004540;nuclease activity#GO:0004518;catalytic activity, acting on RNA#GO:0140098 humoral immune response#GO:0006959;antimicrobial humoral response#GO:0019730;antibacterial humoral response#GO:0019731;multicellular organism development#GO:0007275;vasculature development#GO:0001944;anatomical structure formation involved in morphogenesis#GO:0048646;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;defense response to symbiont#GO:0140546;defense response to other organism#GO:0098542;animal gross anatomical part developmental process#GO:0160108;immune system process#GO:0002376;defense response to bacterium#GO:0042742;angiogenesis#GO:0001525;blood vessel morphogenesis#GO:0048514;defense response to Gram-positive bacterium#GO:0050830;anatomical structure morphogenesis#GO:0009653;circulatory system development#GO:0072359;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;developmental process#GO:0032502;innate immune response#GO:0045087;defense response#GO:0006952;response to external stimulus#GO:0009605;immune response#GO:0006955;multicellular organismal process#GO:0032501;tube development#GO:0035295;response to other organism#GO:0051707;response to bacterium#GO:0009617;anatomical structure development#GO:0048856;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;system development#GO:0048731;blood vessel development#GO:0001568;tube morphogenesis#GO:0035239;response to external biotic stimulus#GO:0043207 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 endoribonuclease#PC00094;RNA metabolism protein#PC00031 HUMAN|HGNC=344|UniProtKB=O43865 O43865 AHCYL1 PTHR23420:SF3 ADENOSYLHOMOCYSTEINASE S-ADENOSYLHOMOCYSTEINE HYDROLASE-LIKE PROTEIN 1 catalytic activity#GO:0003824;hydrolase activity#GO:0016787 sulfur compound metabolic process#GO:0006790;carbohydrate derivative metabolic process#GO:1901135;homocysteine metabolic process#GO:0050667;cellular process#GO:0009987;proteinogenic amino acid metabolic process#GO:0170039;nucleobase-containing compound metabolic process#GO:0006139;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;modified amino acid metabolic process#GO:0006575;purine-containing compound metabolic process#GO:0072521;small molecule metabolic process#GO:0044281;nucleoside metabolic process#GO:0009116;oxoacid metabolic process#GO:0043436;purine nucleoside metabolic process#GO:0042278 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 hydrolase#PC00121;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=3336|UniProtKB=Q14246 Q14246 ADGRE1 PTHR12011:SF449 ADHESION G-PROTEIN COUPLED RECEPTOR ADHESION G PROTEIN-COUPLED RECEPTOR E1 transmembrane signaling receptor activity#GO:0004888;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=41906|UniProtKB=E7EW31 E7EW31 PROB1 PTHR33775:SF1 CARDIAC-ENRICHED FHL2-INTERACTING PROTEIN-RELATED PROLINE-RICH BASIC PROTEIN 1 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634 HUMAN|HGNC=6501|UniProtKB=P13473 P13473 LAMP2 PTHR11506:SF6 LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN 2 macroautophagy#GO:0016236;response to nutrient levels#GO:0031667;macromolecule localization#GO:0033036;intracellular protein localization#GO:0008104;macromolecule metabolic process#GO:0043170;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;vacuolar transport#GO:0007034;cellular response to nutrient levels#GO:0031669;transport#GO:0006810;cellular response to starvation#GO:0009267;intracellular transport#GO:0046907;autophagosome maturation#GO:0097352;protein-containing complex disassembly#GO:0032984;catabolic process#GO:0009056;protein localization to organelle#GO:0033365;cellular response to stimulus#GO:0051716;response to starvation#GO:0042594;primary metabolic process#GO:0044238;localization#GO:0051179;protein metabolic process#GO:0019538;protein localization to vacuole#GO:0072665;autophagy#GO:0006914;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;protein targeting to vacuole#GO:0006623;response to stress#GO:0006950;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;intracellular protein transport#GO:0006886;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;response to stimulus#GO:0050896;establishment of protein localization to vacuole#GO:0072666;protein targeting#GO:0006605;protein localization to lysosome#GO:0061462;cellular component organization#GO:0016043;process utilizing autophagic mechanism#GO:0061919;protein transport#GO:0015031;cellular component disassembly#GO:0022411;cellular localization#GO:0051641;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;lysosomal transport#GO:0007041 intracellular organelle#GO:0043229;endosome membrane#GO:0010008;endosome#GO:0005768;autophagosome#GO:0005776;membrane-bounded organelle#GO:0043227;autophagosome membrane#GO:0000421;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;vesicle#GO:0031982;lysosome#GO:0005764;lytic vacuole membrane#GO:0098852;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;late endosome membrane#GO:0031902;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;lytic vacuole#GO:0000323;vacuolar membrane#GO:0005774;cell periphery#GO:0071944;lysosomal membrane#GO:0005765;vesicle membrane#GO:0012506;membrane#GO:0016020;plasma membrane#GO:0005886;vacuole#GO:0005773;cytoplasm#GO:0005737;late endosome#GO:0005770;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505 membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=21723|UniProtKB=Q8NHE4 Q8NHE4 ATP6V0E2 PTHR12263:SF2 VACUOLAR ATP SYNTHASE SUBUNIT H V-TYPE PROTON ATPASE SUBUNIT E 2 monoatomic ion transmembrane transporter activity#GO:0015075;active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399;proton transmembrane transporter activity#GO:0015078;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic cation transmembrane transporter activity#GO:0008324;ATPase-coupled transmembrane transporter activity#GO:0042626;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATP-dependent activity#GO:0140657 cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;proton transmembrane transport#GO:1902600;establishment of localization#GO:0051234;transmembrane transport#GO:0055085 proton-transporting two-sector ATPase complex#GO:0016469;vacuolar membrane#GO:0005774;transporter complex#GO:1990351;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;proton-transporting V-type ATPase complex#GO:0033176;membrane#GO:0016020;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;vacuole#GO:0005773;ATPase complex#GO:1904949;catalytic complex#GO:1902494;vacuolar proton-transporting V-type ATPase complex#GO:0016471;intracellular organelle#GO:0043229;transmembrane transporter complex#GO:1902495;intracellular anatomical structure#GO:0005622;ATPase dependent transmembrane transport complex#GO:0098533;membrane-bounded organelle#GO:0043227;membrane protein complex#GO:0098796;cation-transporting ATPase complex#GO:0090533;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 ATP synthase#PC00002;primary active transporter#PC00068 HUMAN|HGNC=28323|UniProtKB=Q96C00 Q96C00 ZBTB9 PTHR46105:SF13 AGAP004733-PA ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 9 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=30366|UniProtKB=Q92545 Q92545 TMEM131 PTHR22050:SF1 RW1 PROTEIN HOMOLOG TRANSMEMBRANE PROTEIN 131 metabolic process#GO:0008152;cellular process#GO:0009987;biosynthetic process#GO:0009058 cellular anatomical structure#GO:0110165;membrane#GO:0016020 HUMAN|HGNC=20516|UniProtKB=Q6DN03 Q6DN03 H2BC20P PTHR23428:SF298 HISTONE H2B HISTONE H2B TYPE 2-C-RELATED defense response to bacterium#GO:0042742;response to bacterium#GO:0009617;immune system process#GO:0002376;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to stimulus#GO:0050896;humoral immune response#GO:0006959;antimicrobial humoral response#GO:0019730;response to external stimulus#GO:0009605;defense response#GO:0006952;antibacterial humoral response#GO:0019731;innate immune response#GO:0045087;defense response to symbiont#GO:0140546;immune response#GO:0006955;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;response to other organism#GO:0051707;defense response to other organism#GO:0098542 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=7900|UniProtKB=P55786 P55786 NPEPPS PTHR11533:SF174 PROTEASE M1 ZINC METALLOPROTEASE PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED exopeptidase activity#GO:0008238;hydrolase activity#GO:0016787;metalloaminopeptidase activity#GO:0070006;metallopeptidase activity#GO:0008237;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;catalytic activity#GO:0003824;aminopeptidase activity#GO:0004177;metalloexopeptidase activity#GO:0008235 primary metabolic process#GO:0044238;cellular process#GO:0009987;peptide catabolic process#GO:0043171;catabolic process#GO:0009056;proteolysis#GO:0006508;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518 protease#PC00190;metalloprotease#PC00153 HUMAN|HGNC=21666|UniProtKB=Q3MIW9 Q3MIW9 MUCL3 PTHR22094:SF0 DIFFUSE PANBRONCHIOLITIS CRITICAL REGION GENE 1 MUCIN-LIKE PROTEIN 3 HUMAN|HGNC=13574|UniProtKB=Q9UBF1 Q9UBF1 MAGEC2 PTHR11736:SF84 MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN MELANOMA-ASSOCIATED ANTIGEN C2 regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 scaffold/adaptor protein#PC00226 HUMAN|HGNC=9109|UniProtKB=P20382 P20382 PMCH PTHR12091:SF0 MELANIN-CONCENTRATING HORMONE PRO-MCH protein binding#GO:0005515;G protein-coupled receptor binding#GO:0001664;signaling receptor binding#GO:0005102;binding#GO:0005488;neuropeptide receptor binding#GO:0071855 regulation of trans-synaptic signaling#GO:0099177;regulation of cellular process#GO:0050794;modulation of chemical synaptic transmission#GO:0050804;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of cell communication#GO:0010648;negative regulation of signaling#GO:0023057;negative regulation of cellular process#GO:0048523;regulation of signaling#GO:0023051 intercellular signal molecule#PC00207;peptide hormone#PC00179 HUMAN|HGNC=28660|UniProtKB=Q9BUE6 Q9BUE6 ISCA1 PTHR10072:SF65 IRON-SULFUR CLUSTER ASSEMBLY PROTEIN IRON-SULFUR CLUSTER ASSEMBLY 1 HOMOLOG, MITOCHONDRIAL iron-sulfur cluster binding#GO:0051536;binding#GO:0005488;small molecule binding#GO:0036094 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;iron-sulfur cluster assembly#GO:0016226;biosynthetic process#GO:0009058;cellular component assembly#GO:0022607;protein maturation#GO:0051604;gene expression#GO:0010467;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;protein metabolic process#GO:0019538 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 chaperone#PC00072 HUMAN|HGNC=2953|UniProtKB=Q9NYC9 Q9NYC9 DNAH9 PTHR10676:SF257 DYNEIN HEAVY CHAIN FAMILY PROTEIN DYNEIN AXONEMAL HEAVY CHAIN 9 protein binding#GO:0005515;microtubule motor activity#GO:0003777;polypeptide conformation or assembly isomerase activity#GO:0120544;binding#GO:0005488;ATP-dependent activity#GO:0140657;cytoskeletal motor activity#GO:0003774;isomerase activity#GO:0016853;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543 microtubule-based process#GO:0007017;cilium-dependent cell motility#GO:0060285;cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;cell motility#GO:0048870;microtubule-based movement#GO:0007018;cellular process#GO:0009987;cilium movement involved in cell motility#GO:0060294 intracellular organelle#GO:0043229;cilium#GO:0005929;catalytic complex#GO:1902494;9+2 motile cilium#GO:0097729;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;axoneme#GO:0005930;dynein complex#GO:0030286;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;motile cilium#GO:0031514;cellular anatomical structure#GO:0110165;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;ciliary plasm#GO:0097014;microtubule associated complex#GO:0005875 microtubule or microtubule-binding cytoskeletal protein#PC00157;microtubule binding motor protein#PC00156 HUMAN|HGNC=6135|UniProtKB=O75578 O75578 ITGA10 PTHR23220:SF26 INTEGRIN ALPHA INTEGRIN ALPHA-10 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell surface receptor signaling pathway#GO:0007166;cell adhesion#GO:0007155;cell-matrix adhesion#GO:0007160;cell communication#GO:0007154;cell-substrate adhesion#GO:0031589;cell-cell adhesion#GO:0098609;integrin-mediated signaling pathway#GO:0007229;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007 plasma membrane#GO:0005886;cell surface#GO:0009986;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane protein complex#GO:0098797;protein complex involved in cell adhesion#GO:0098636;cell periphery#GO:0071944;membrane protein complex#GO:0098796;membrane#GO:0016020;integrin complex#GO:0008305;signaling receptor complex#GO:0043235 cell adhesion molecule#PC00069;integrin#PC00126 Integrin signalling pathway#P00034>Integrin alpha#P00941 HUMAN|HGNC=18550|UniProtKB=Q9Y5U9 Q9Y5U9 IER3IP1 PTHR15858:SF7 IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1 IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1 intracellular transport#GO:0046907;transport#GO:0006810;Golgi vesicle transport#GO:0048193;positive regulation of protein secretion#GO:0050714;establishment of localization#GO:0051234;regulation of localization#GO:0032879;regulation of transport#GO:0051049;cellular process#GO:0009987;positive regulation of secretion by cell#GO:1903532;positive regulation of transport#GO:0051050;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;biological regulation#GO:0065007;positive regulation of cellular component organization#GO:0051130;positive regulation of secretion#GO:0051047;cellular localization#GO:0051641;localization#GO:0051179;regulation of secretion#GO:0051046;regulation of secretion by cell#GO:1903530;regulation of establishment of protein localization#GO:0070201;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;regulation of protein localization#GO:0032880;regulation of protein secretion#GO:0050708;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of protein transport#GO:0051223;regulation of cellular component organization#GO:0051128 organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;endoplasmic reticulum membrane#GO:0005789;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783 HUMAN|HGNC=18149|UniProtKB=Q9NPC4 Q9NPC4 A4GALT PTHR12042:SF17 LACTOSYLCERAMIDE 4-ALPHA-GALACTOSYLTRANSFERASE ALPHA- 1,4-GALACTOSYLTRANSFERASE LACTOSYLCERAMIDE 4-ALPHA-GALACTOSYLTRANSFERASE galactosyltransferase activity#GO:0008378;glycosyltransferase activity#GO:0016757;hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740 sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;sphingolipid biosynthetic process#GO:0030148;glycosphingolipid biosynthetic process#GO:0006688;lipid metabolic process#GO:0006629;glycolipid biosynthetic process#GO:0009247;carbohydrate derivative biosynthetic process#GO:1901137;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;liposaccharide metabolic process#GO:1903509;glycolipid metabolic process#GO:0006664;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058 metabolite interconversion enzyme#PC00262;transferase#PC00220 HUMAN|HGNC=17011|UniProtKB=Q9BUJ2 Q9BUJ2 HNRNPUL1 PTHR12381:SF41 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN U FAMILY MEMBER HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN U-LIKE PROTEIN 1 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;macromolecule metabolic process#GO:0043170;alternative mRNA splicing, via spliceosome#GO:0000380;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=29915|UniProtKB=Q5VU65 Q5VU65 NUP210L PTHR23019:SF1 NUCLEAR PORE MEMBRANE GLYCOPROTEIN GP210-RELATED NUCLEAR PORE MEMBRANE GLYCOPROTEIN 210-LIKE nucleus#GO:0005634;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;nuclear pore#GO:0005643;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 transporter#PC00227 HUMAN|HGNC=12102|UniProtKB=A0A0B4J238 A0A0B4J238 TRAV1-2 PTHR19433:SF105 T-CELL RECEPTOR ALPHA CHAIN V REGION-RELATED T CELL RECEPTOR ALPHA VARIABLE 1-1-RELATED response to bacterium#GO:0009617;response to biotic stimulus#GO:0009607;response to other organism#GO:0051707;response to external stimulus#GO:0009605;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=928|UniProtKB=O43286 O43286 B4GALT5 PTHR19300:SF45 BETA-1,4-GALACTOSYLTRANSFERASE BETA-1,4-GALACTOSYLTRANSFERASE 5 hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740;galactosyltransferase activity#GO:0008378;glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194 sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;sphingolipid biosynthetic process#GO:0030148;glycosphingolipid biosynthetic process#GO:0006688;lipid metabolic process#GO:0006629;glycolipid biosynthetic process#GO:0009247;carbohydrate derivative biosynthetic process#GO:1901137;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;liposaccharide metabolic process#GO:1903509;glycolipid metabolic process#GO:0006664;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 metabolite interconversion enzyme#PC00262;glycosyltransferase#PC00111 HUMAN|HGNC=20808|UniProtKB=Q9H8G1 Q9H8G1 ZNF430 PTHR24384:SF131 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED ZINC FINGER PROTEIN 430 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 HUMAN|HGNC=10962|UniProtKB=O94956 O94956 SLCO2B1 PTHR11388:SF87 ORGANIC ANION TRANSPORTER SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 2B1 secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;transport#GO:0006810;cellular process#GO:0009987 apical part of cell#GO:0045177;plasma membrane#GO:0005886;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;basal plasma membrane#GO:0009925;cell periphery#GO:0071944;basolateral plasma membrane#GO:0016323;basal part of cell#GO:0045178;apical plasma membrane#GO:0016324;membrane#GO:0016020 transporter#PC00227 HUMAN|HGNC=33768|UniProtKB=Q6UWT4 Q6UWT4 C5orf46 PTHR37864:SF1 SIMILAR TO AVLV472 SIMILAR TO HUMAN CHROMOSOME 5 OPEN READING FRAME 46 HUMAN|HGNC=21158|UniProtKB=Q8IUD6 Q8IUD6 RNF135 PTHR25465:SF41 B-BOX DOMAIN CONTAINING E3 UBIQUITIN-PROTEIN LIGASE RNF135 ubiquitin-protein transferase activity#GO:0004842;protein-containing complex binding#GO:0044877;ribonucleoprotein complex binding#GO:0043021;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;binding#GO:0005488;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740 regulation of response to stress#GO:0080134;regulation of response to stimulus#GO:0048583;regulation of defense response#GO:0031347;regulation of immune response#GO:0050776;regulation of innate immune response#GO:0045088;regulation of biological process#GO:0050789;regulation of immune system process#GO:0002682;regulation of response to external stimulus#GO:0032101;regulation of response to biotic stimulus#GO:0002831;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=12779|UniProtKB=O14905 O14905 WNT9B PTHR12027:SF84 WNT RELATED PROTEIN WNT-9B receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;frizzled binding#GO:0005109;G protein-coupled receptor binding#GO:0001664;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;cytokine activity#GO:0005125;signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515;molecular function activator activity#GO:0140677 regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;cell differentiation#GO:0030154;Wnt signaling pathway#GO:0016055;regulation of cellular process#GO:0050794;signaling#GO:0023052;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;cell communication#GO:0007154;canonical Wnt signaling pathway#GO:0060070;anatomical structure development#GO:0048856;system development#GO:0048731;cell fate commitment#GO:0045165;signal transduction#GO:0007165;cellular process#GO:0009987;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;nervous system development#GO:0007399;neuron differentiation#GO:0030182;developmental process#GO:0032502;cell surface receptor signaling pathway#GO:0007166;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;neurogenesis#GO:0022008 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 Cadherin signaling pathway#P00012>Wnt#P00474;Alzheimer disease-presenilin pathway#P00004>Wnt#P00142;Wnt signaling pathway#P00057>Wnt#P01444 HUMAN|HGNC=17349|UniProtKB=O43172 O43172 PRPF4 PTHR19846:SF5 WD40 REPEAT PROTEIN U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP4 binding#GO:0005488;nucleic acid binding#GO:0003676;snRNA binding#GO:0017069;RNA binding#GO:0003723 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;mRNA cis splicing, via spliceosome#GO:0045292;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377 Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513;protein-containing complex#GO:0032991;U4/U6 x U5 tri-snRNP complex#GO:0046540;small nuclear ribonucleoprotein complex#GO:0030532;nucleus#GO:0005634;spliceosomal snRNP complex#GO:0097525;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ribonucleoprotein complex#GO:1990904;precatalytic spliceosome#GO:0071011;spliceosomal tri-snRNP complex#GO:0097526;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;spliceosomal complex#GO:0005681 RNA processing factor#PC00147;RNA splicing factor#PC00148 HUMAN|HGNC=28841|UniProtKB=O60811 O60811 PRAMEF2 PTHR14224:SF98 SIMILAR TO PREFERENTIALLY EXPRESSED ANTIGEN IN MELANOMA-LIKE 3 PRAME FAMILY MEMBER 2 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;enzyme-substrate adaptor activity#GO:0140767;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056 ubiquitin ligase complex#GO:0000151;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;Cul2-RING ubiquitin ligase complex#GO:0031462;catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;cullin-RING ubiquitin ligase complex#GO:0031461 HUMAN|HGNC=29321|UniProtKB=Q9HCH0 Q9HCH0 NCKAP5L PTHR21740:SF3 NCK-ASSOCIATED PROTEIN 5 NCK-ASSOCIATED PROTEIN 5-LIKE microtubule bundle formation#GO:0001578;supramolecular fiber organization#GO:0097435;protein-containing complex organization#GO:0043933;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;cellular component disassembly#GO:0022411;microtubule cytoskeleton organization#GO:0000226;cellular process#GO:0009987;organelle organization#GO:0006996;microtubule polymerization or depolymerization#GO:0031109;cellular component organization#GO:0016043;cytoskeleton organization#GO:0007010;protein-containing complex disassembly#GO:0032984;protein depolymerization#GO:0051261;microtubule depolymerization#GO:0007019 cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;microtubule end#GO:1990752;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;microtubule#GO:0005874;microtubule plus-end#GO:0035371;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 HUMAN|HGNC=12780|UniProtKB=P09544 P09544 WNT2 PTHR12027:SF86 WNT RELATED PROTEIN WNT-2 protein binding#GO:0005515;molecular function activator activity#GO:0140677;binding#GO:0005488;signaling receptor binding#GO:0005102;cytokine activity#GO:0005125;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;frizzled binding#GO:0005109;G protein-coupled receptor binding#GO:0001664 multicellular organismal process#GO:0032501;nervous system development#GO:0007399;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;neurogenesis#GO:0022008;cell surface receptor signaling pathway#GO:0007166;developmental process#GO:0032502;neuron differentiation#GO:0030182;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cell differentiation#GO:0030154;Wnt signaling pathway#GO:0016055;signaling#GO:0023052;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;anatomical structure development#GO:0048856;canonical Wnt signaling pathway#GO:0060070;cell communication#GO:0007154;cell fate commitment#GO:0045165;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 Cadherin signaling pathway#P00012>Wnt#P00474;Angiogenesis#P00005>Wnt#P00206;Wnt signaling pathway#P00057>Wnt#P01444;Alzheimer disease-presenilin pathway#P00004>Wnt#P00142 HUMAN|HGNC=32190|UniProtKB=Q6DKI7 Q6DKI7 PVRIG PTHR39220:SF1 TRANSMEMBRANE PROTEIN PVRIG TRANSMEMBRANE PROTEIN PVRIG HUMAN|HGNC=4495|UniProtKB=O43193 O43193 MLNR PTHR24243:SF3 G-PROTEIN COUPLED RECEPTOR MOTILIN RECEPTOR signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021 HUMAN|HGNC=27314|UniProtKB=A8MSI8 A8MSI8 LYRM9 PTHR47061:SF1 LYR MOTIF-CONTAINING PROTEIN 9 LYR MOTIF-CONTAINING PROTEIN 9 HUMAN|HGNC=29532|UniProtKB=Q53QV2 Q53QV2 LBH PTHR14987:SF2 PROTEIN LBH-RELATED PROTEIN LBH regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=15038|UniProtKB=Q6UXT6 Q6UXT6 OR9H1 PTHR48018:SF105 OLFACTORY RECEPTOR OLFACTORY RECEPTOR OR9H1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signaling#GO:0023052;regulation of cellular process#GO:0050794;sensory perception of smell#GO:0007608;response to stimulus#GO:0050896;nervous system process#GO:0050877;sensory perception#GO:0007600;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signal transduction#GO:0007165;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=25320|UniProtKB=Q8ND61 Q8ND61 C3orf20 PTHR23093:SF20 SIMILAR TO CHROMOSOME 3 OPEN READING FRAME 20 SIMILAR TO HUMAN CHROMOSOME 3 OPEN READING FRAME 20 HUMAN|HGNC=932|UniProtKB=Q14032 Q14032 BAAT PTHR10824:SF18 ACYL-COENZYME A THIOESTERASE-RELATED BILE ACID-COA:AMINO ACID N-ACYLTRANSFERASE catalytic activity#GO:0003824;transferase activity#GO:0016740;deacylase activity#GO:0160215;hydrolase activity, acting on ester bonds#GO:0016788;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acyltransferase activity#GO:0016746;fatty acyl-CoA hydrolase activity#GO:0047617;acyl-CoA hydrolase activity#GO:0016289;thiolester hydrolase activity#GO:0016790;hydrolase activity#GO:0016787 purine-containing compound metabolic process#GO:0072521;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;phosphorus metabolic process#GO:0006793;monocarboxylic acid metabolic process#GO:0032787;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;oxoacid metabolic process#GO:0043436;cellular process#GO:0009987;sulfur compound metabolic process#GO:0006790;organophosphate metabolic process#GO:0019637;nucleobase-containing compound metabolic process#GO:0006139;steroid metabolic process#GO:0008202;lipid metabolic process#GO:0006629;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;acyl-CoA metabolic process#GO:0006637 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cytosol#GO:0005829;peroxisome#GO:0005777;microbody#GO:0042579 esterase#PC00097 HUMAN|HGNC=9359|UniProtKB=P58743 P58743 SLC26A5 PTHR11814:SF32 SULFATE TRANSPORTER PRESTIN antiporter activity#GO:0015297;bicarbonate transmembrane transporter activity#GO:0015106;chloride transmembrane transporter activity#GO:0015108;secondary active transmembrane transporter activity#GO:0015291;monoatomic anion transmembrane transporter activity#GO:0008509;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;dicarboxylic acid transmembrane transporter activity#GO:0005310;active transmembrane transporter activity#GO:0022804;carboxylic acid transmembrane transporter activity#GO:0046943 nervous system process#GO:0050877;sensory perception#GO:0007600;sensory perception of mechanical stimulus#GO:0050954;transmembrane transport#GO:0055085;localization#GO:0051179;chloride transmembrane transport#GO:1902476;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698;monoatomic anion transport#GO:0006820;sensory perception of sound#GO:0007605;chloride transport#GO:0006821;organic acid transport#GO:0015849;transport#GO:0006810;carboxylic acid transport#GO:0046942;establishment of localization#GO:0051234;system process#GO:0003008;cellular process#GO:0009987;multicellular organismal process#GO:0032501;monoatomic anion transmembrane transport#GO:0098656;dicarboxylic acid transport#GO:0006835;monoatomic ion transmembrane transport#GO:0034220 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227 HUMAN|HGNC=21065|UniProtKB=O95847 O95847 SLC25A27 PTHR45618:SF8 MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED MITOCHONDRIAL UNCOUPLING PROTEIN 4 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 response to temperature stimulus#GO:0009266;response to stimulus#GO:0050896;response to cold#GO:0009409;response to abiotic stimulus#GO:0009628;response to stress#GO:0006950 mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrial inner membrane#GO:0005743;organelle envelope#GO:0031967;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090 transporter#PC00227;secondary carrier transporter#PC00258 HUMAN|HGNC=16715|UniProtKB=Q9H8H2 Q9H8H2 DDX31 PTHR24031:SF89 RNA HELICASE ATP-DEPENDENT DNA HELICASE DDX31 ribonucleoprotein complex biogenesis#GO:0022613;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;ribosome biogenesis#GO:0042254;cellular component biogenesis#GO:0044085 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 RNA helicase#PC00032;RNA metabolism protein#PC00031 HUMAN|HGNC=11457|UniProtKB=O75897 O75897 SULT1C4 PTHR11783:SF327 SULFOTRANSFERASE SULT SULFOTRANSFERASE 1C4 transferase activity#GO:0016740;catalytic activity#GO:0003824;sulfotransferase activity#GO:0008146;transferase activity, transferring sulphur-containing groups#GO:0016782 cellular process#GO:0009987;metabolic process#GO:0008152;sulfur compound metabolic process#GO:0006790 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;transferase#PC00220 HUMAN|HGNC=20063|UniProtKB=Q86T82 Q86T82 USP37 PTHR24006:SF686 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 37 cysteine-type peptidase activity#GO:0008234;cysteine-type deubiquitinase activity#GO:0004843;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787 biological regulation#GO:0065007;mitotic cell cycle#GO:0000278;cell cycle phase transition#GO:0044770;cell cycle G1/S phase transition#GO:0044843;regulation of protein stability#GO:0031647;cellular process#GO:0009987;cell cycle process#GO:0022402;cell cycle#GO:0007049;mitotic cell cycle process#GO:1903047;regulation of biological quality#GO:0065008;mitotic cell cycle phase transition#GO:0044772;G1/S transition of mitotic cell cycle#GO:0000082 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;cytosol#GO:0005829;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 protease#PC00190;cysteine protease#PC00081 HUMAN|HGNC=6154|UniProtKB=Q9UKP3 Q9UKP3 ITGB1BP2 PTHR12621:SF8 CYSTEINE AND HISTIDINE-RICH DOMAIN CHORD -CONTAINING PROTEIN INTEGRIN BETA-1-BINDING PROTEIN 2 transition metal ion binding#GO:0046914;ion binding#GO:0043167;zinc ion binding#GO:0008270;small molecule binding#GO:0036094;binding#GO:0005488;cation binding#GO:0043169;metal ion binding#GO:0046872 cellular process#GO:0009987;cell cycle process#GO:0022402;centrosome cycle#GO:0007098;cellular component organization#GO:0016043;organelle organization#GO:0006996;cell cycle#GO:0007049;cytoskeleton organization#GO:0007010;centrosome duplication#GO:0051298;microtubule-based process#GO:0007017;microtubule organizing center organization#GO:0031023;microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840 intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;myofibril#GO:0030016;membraneless organelle#GO:0043228;sarcomere#GO:0030017;intracellular organelle#GO:0043229;I band#GO:0031674;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;organelle#GO:0043226;supramolecular complex#GO:0099080;Z disc#GO:0030018;contractile muscle fiber#GO:0043292 scaffold/adaptor protein#PC00226 HUMAN|HGNC=18177|UniProtKB=Q8TF65 Q8TF65 GIPC2 PTHR12259:SF3 RGS-GAIP INTERACTING PROTEIN GIPC PDZ DOMAIN-CONTAINING PROTEIN GIPC2 scaffold/adaptor protein#PC00226 HUMAN|HGNC=10721|UniProtKB=P16109 P16109 SELP PTHR19325:SF484 COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING P-SELECTIN oligosaccharide binding#GO:0070492;carbohydrate derivative binding#GO:0097367;carbohydrate binding#GO:0030246;anion binding#GO:0043168;carboxylic acid binding#GO:0031406;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;organic acid binding#GO:0043177 leukocyte migration#GO:0050900;immune system process#GO:0002376;cell adhesion#GO:0007155;response to peptide#GO:1901652;cell-cell adhesion#GO:0098609;cellular process#GO:0009987;heterophilic cell-cell adhesion#GO:0007157;leukocyte cell-cell adhesion#GO:0007159;cell motility#GO:0048870;cell migration#GO:0016477;response to stimulus#GO:0050896;response to cytokine#GO:0034097;response to chemical#GO:0042221 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;plasma membrane#GO:0005886;external side of plasma membrane#GO:0009897;extracellular region#GO:0005576;side of membrane#GO:0098552 complement component#PC00078;defense/immunity protein#PC00090 HUMAN|HGNC=25891|UniProtKB=Q8N4T8 Q8N4T8 CBR4 PTHR42760:SF133 SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER 3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 oxidoreductase#PC00176 HUMAN|HGNC=15510|UniProtKB=P47883 P47883 OR3A4P PTHR48001:SF100 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 3A4-RELATED transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;cell communication#GO:0007154 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=10316|UniProtKB=P62829 P62829 RPL23 PTHR11761:SF22 50S/60S RIBOSOMAL PROTEIN L14/L23 LARGE RIBOSOMAL SUBUNIT PROTEIN UL14 rRNA binding#GO:0019843;nucleic acid binding#GO:0003676;structural constituent of ribosome#GO:0003735;binding#GO:0005488;RNA binding#GO:0003723;structural molecule activity#GO:0005198 ribosome#GO:0005840;cytosol#GO:0005829;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 translational protein#PC00263;ribosomal protein#PC00202 HUMAN|HGNC=19425|UniProtKB=Q96P70 Q96P70 IPO9 PTHR10997:SF9 IMPORTIN-7, 8, 11 IMPORTIN-9 molecular carrier activity#GO:0140104;nucleocytoplasmic carrier activity#GO:0140142 protein transport#GO:0015031;protein import into nucleus#GO:0006606;nuclear transport#GO:0051169;cellular localization#GO:0051641;localization#GO:0051179;nucleocytoplasmic transport#GO:0006913;protein localization to organelle#GO:0033365;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;protein localization to nucleus#GO:0034504;import into nucleus#GO:0051170;macromolecule localization#GO:0033036 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;organelle envelope#GO:0031967;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nuclear envelope#GO:0005635;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226 transporter#PC00227 HUMAN|HGNC=1720|UniProtKB=Q13042 Q13042 CDC16 PTHR12558:SF9 CELL DIVISION CYCLE 16,23,27 CELL DIVISION CYCLE PROTEIN 16 HOMOLOG enzyme-substrate adaptor activity#GO:0140767;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 regulation of cellular process#GO:0050794;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;catabolic process#GO:0009056;cell division#GO:0051301;modification-dependent protein catabolic process#GO:0019941;protein modification process#GO:0036211;primary metabolic process#GO:0044238;regulation of cell cycle phase transition#GO:1901987;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;regulation of nuclear division#GO:0051783;biological regulation#GO:0065007;regulation of mitotic metaphase/anaphase transition#GO:0030071;regulation of mitotic cell cycle#GO:0007346;positive regulation of cellular process#GO:0048522;positive regulation of mitotic cell cycle#GO:0045931;ubiquitin-dependent protein catabolic process#GO:0006511;regulation of mitotic nuclear division#GO:0007088;regulation of mitotic sister chromatid separation#GO:0010965;macromolecule metabolic process#GO:0043170;regulation of chromosome organization#GO:0033044;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;regulation of sister chromatid segregation#GO:0033045;regulation of cell cycle#GO:0051726;regulation of cellular component organization#GO:0051128;regulation of organelle organization#GO:0033043;protein modification by small protein conjugation#GO:0032446;positive regulation of cell cycle process#GO:0090068;regulation of biological process#GO:0050789;positive regulation of organelle organization#GO:0010638;regulation of mitotic cell cycle phase transition#GO:1901990;modification-dependent macromolecule catabolic process#GO:0043632;anaphase-promoting complex-dependent catabolic process#GO:0031145;positive regulation of cellular component organization#GO:0051130;protein catabolic process#GO:0030163;protein modification by small protein conjugation or removal#GO:0070647;proteasomal protein catabolic process#GO:0010498;positive regulation of cell cycle#GO:0045787;regulation of cell cycle process#GO:0010564;protein ubiquitination#GO:0016567;regulation of chromosome separation#GO:1905818;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;regulation of chromosome segregation#GO:0051983;positive regulation of mitotic nuclear division#GO:0045840;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152 cullin-RING ubiquitin ligase complex#GO:0031461;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear ubiquitin ligase complex#GO:0000152;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;anaphase-promoting complex#GO:0005680;nucleus#GO:0005634;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=20437|UniProtKB=Q719I0 Q719I0 AHSA2P PTHR13009:SF4 HEAT SHOCK PROTEIN 90 HSP90 CO-CHAPERONE AHA-1 ACTIVATOR OF 90 KDA HEAT SHOCK PROTEIN ATPASE HOMOLOG 2-RELATED ATPase activator activity#GO:0001671;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772 primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;protein folding#GO:0006457;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 chaperone#PC00072 HUMAN|HGNC=1458|UniProtKB=O43852 O43852 CALU PTHR10827:SF76 RETICULOCALBIN CALUMENIN metal ion binding#GO:0046872;cation binding#GO:0043169;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;calcium ion binding#GO:0005509 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 calcium-binding protein#PC00060;calmodulin-related#PC00061 HUMAN|HGNC=25926|UniProtKB=Q5VYS4 Q5VYS4 MEDAG PTHR33769:SF3 TESTIS-EXPRESSED PROTEIN 26 ISOFORM X3 MESENTERIC ESTROGEN-DEPENDENT ADIPOGENESIS PROTEIN cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=16999|UniProtKB=Q92989 Q92989 CLP1 PTHR12755:SF6 CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1 transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleobase-containing compound kinase activity#GO:0019205;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773 macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;tRNA splicing, via endonucleolytic cleavage and ligation#GO:0006388 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031;mRNA polyadenylation factor#PC00146;RNA processing factor#PC00147 HUMAN|HGNC=15207|UniProtKB=Q96RD2 Q96RD2 OR52B2 PTHR26450:SF151 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 52B2 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=15285|UniProtKB=Q8NGL1 Q8NGL1 OR5D18 PTHR48018:SF121 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5D18 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;nervous system process#GO:0050877;sensory perception#GO:0007600;sensory perception of smell#GO:0007608;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=18091|UniProtKB=Q30KQ9 Q30KQ9 DEFB110 PTHR20515:SF19 BETA-DEFENSIN BETA-DEFENSIN 110 signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;G protein-coupled receptor binding#GO:0001664;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;signaling receptor binding#GO:0005102;cytokine receptor binding#GO:0005126;binding#GO:0005488;protein binding#GO:0005515;chemokine receptor binding#GO:0042379;molecular function activator activity#GO:0140677 cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;cell motility#GO:0048870;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;locomotion#GO:0040011;cellular response to chemical stimulus#GO:0070887;response to bacterium#GO:0009617;chemotaxis#GO:0006935;defense response to bacterium#GO:0042742;cell chemotaxis#GO:0060326;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;cellular process#GO:0009987;response to chemical#GO:0042221;taxis#GO:0042330;cell migration#GO:0016477;response to other organism#GO:0051707;response to external stimulus#GO:0009605;defense response#GO:0006952 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090;antimicrobial response protein#PC00051 HUMAN|HGNC=1553|UniProtKB=Q13185 Q13185 CBX3 PTHR22812:SF134 CHROMOBOX PROTEIN CHROMOBOX PROTEIN HOMOLOG 3 chromatin binding#GO:0003682;binding#GO:0005488 regulation of biological process#GO:0050789;heterochromatin formation#GO:0031507;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;heterochromatin organization#GO:0070828;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;chromatin organization#GO:0006325;cellular component assembly#GO:0022607;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of gene expression, epigenetic#GO:0045814;cellular component organization or biogenesis#GO:0071840 chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;heterochromatin#GO:0000792;intracellular organelle#GO:0043229;chromosome, centromeric region#GO:0000775;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165;chromatin#GO:0000785;chromosome#GO:0005694 HUMAN|HGNC=23060|UniProtKB=P58005 P58005 SESN3 PTHR12474:SF4 P53 REGULATED PA26 NUCLEAR PROTEIN SESTRIN SESTRIN-3 amino acid binding#GO:0016597;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;ion binding#GO:0043167;carboxylic acid binding#GO:0031406;binding#GO:0005488;anion binding#GO:0043168;small molecule binding#GO:0036094;organic acid binding#GO:0043177;cation binding#GO:0043169;oxidoreductase activity, acting on peroxide as acceptor#GO:0016684 regulation of TOR signaling#GO:0032006;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;cellular response to oxygen-containing compound#GO:1901701;response to acid chemical#GO:0001101;response to stress#GO:0006950;positive regulation of autophagy#GO:0010508;negative regulation of signal transduction#GO:0009968;response to chemical#GO:0042221;cellular response to amino acid starvation#GO:0034198;negative regulation of TORC1 signaling#GO:1904262;regulation of macroautophagy#GO:0016241;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of autophagy#GO:0010506;positive regulation of macroautophagy#GO:0016239;response to stimulus#GO:0050896;cellular response to amino acid stimulus#GO:0071230;regulation of signaling#GO:0023051;cellular response to stress#GO:0033554;response to oxygen-containing compound#GO:1901700;regulation of intracellular signal transduction#GO:1902531;cellular response to chemical stimulus#GO:0070887;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;positive regulation of metabolic process#GO:0009893;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;response to nutrient levels#GO:0031667;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of response to stimulus#GO:0048585;cellular response to nitrogen compound#GO:1901699;regulation of response to stimulus#GO:0048583;cellular response to nutrient levels#GO:0031669;negative regulation of cellular process#GO:0048523;cellular response to starvation#GO:0009267;regulation of catabolic process#GO:0009894;regulation of TORC1 signaling#GO:1903432;positive regulation of catabolic process#GO:0009896;cellular response to stimulus#GO:0051716;response to starvation#GO:0042594;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;negative regulation of TOR signaling#GO:0032007;response to nitrogen compound#GO:1901698 peroxidase#PC00180;oxidoreductase#PC00176 HUMAN|HGNC=4468|UniProtKB=Q9UKP6 Q9UKP6 UTS2R PTHR24230:SF60 G-PROTEIN COUPLED RECEPTOR UROTENSIN-2 RECEPTOR G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;neuropeptide signaling pathway#GO:0007218;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021 HUMAN|HGNC=25398|UniProtKB=Q86T26 Q86T26 TMPRSS11B PTHR24253:SF56 TRANSMEMBRANE PROTEASE SERINE TRANSMEMBRANE PROTEASE SERINE 11B serine-type peptidase activity#GO:0008236;catalytic activity#GO:0003824;serine hydrolase activity#GO:0017171;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096 proteolysis#GO:0006508;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 protease#PC00190;serine protease#PC00203;protein modifying enzyme#PC00260 HUMAN|HGNC=24090|UniProtKB=Q6UW56 Q6UW56 ATRAID PTHR15926:SF1 ALL-TRANS RETINOIC ACID-INDUCED DIFFERENTIATION FACTOR ALL-TRANS RETINOIC ACID-INDUCED DIFFERENTIATION FACTOR HUMAN|HGNC=6230|UniProtKB=O43448 O43448 KCNAB3 PTHR43150:SF3 HYPERKINETIC, ISOFORM M VOLTAGE-GATED POTASSIUM CHANNEL SUBUNIT BETA-3 molecular function regulator activity#GO:0098772;alcohol dehydrogenase (NADP+) activity#GO:0008106;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;ion channel regulator activity#GO:0099106;catalytic activity#GO:0003824;channel regulator activity#GO:0016247;protein binding#GO:0005515;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;potassium channel regulator activity#GO:0015459;transmembrane transporter binding#GO:0044325;transporter regulator activity#GO:0141108;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;binding#GO:0005488 regulation of monoatomic cation transmembrane transport#GO:1904062;regulation of transport#GO:0051049;regulation of localization#GO:0032879;regulation of transmembrane transport#GO:0034762;regulation of monoatomic ion transmembrane transport#GO:0034765;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of metal ion transport#GO:0010959;regulation of monoatomic ion transport#GO:0043269;biological regulation#GO:0065007 cation channel complex#GO:0034703;voltage-gated potassium channel complex#GO:0008076;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane#GO:0005886;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 HUMAN|HGNC=25377|UniProtKB=Q96LZ2 Q96LZ2 MAGEB10 PTHR11736:SF157 MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN MELANOMA-ASSOCIATED ANTIGEN B10 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 scaffold/adaptor protein#PC00226 HUMAN|HGNC=1185|UniProtKB=Q9NQ88 Q9NQ88 TIGAR PTHR46517:SF1 FRUCTOSE-2,6-BISPHOSPHATASE TIGAR FRUCTOSE-2,6-BISPHOSPHATASE TIGAR hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;sugar-phosphatase activity#GO:0050308;hydrolase activity, acting on ester bonds#GO:0016788 negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of catabolic process#GO:0009894;negative regulation of catabolic process#GO:0009895;negative regulation of cellular process#GO:0048523;regulation of carbohydrate metabolic process#GO:0006109;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;negative regulation of metabolic process#GO:0009892;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 phosphatase#PC00181;metabolite interconversion enzyme#PC00262 Cobalamin biosynthesis#P02735>Ribazole-5-phosphate phosphatase#P02881 HUMAN|HGNC=8727|UniProtKB=Q15154 Q15154 PCM1 PTHR14164:SF12 PERICENTRIOLAR MATERIAL 1-RELATED PERICENTRIOLAR MATERIAL 1 PROTEIN cilium assembly#GO:0060271;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cell projection assembly#GO:0030031;cell projection organization#GO:0030030;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031;cellular component organization or biogenesis#GO:0071840;non-motile cilium assembly#GO:1905515;cilium organization#GO:0044782 cilium#GO:0005929;intracellular organelle#GO:0043229;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=30239|UniProtKB=Q9H1C7 Q9H1C7 CYSTM1 PTHR47564:SF1 CYSTEINE-RICH AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 1 CYSTEINE-RICH TRANSMEMBRANE MODULE-CONTAINING PROTEIN 1 HUMAN|HGNC=3093|UniProtKB=Q92630 Q92630 DYRK2 PTHR24058:SF51 DUAL SPECIFICITY PROTEIN KINASE DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 2 protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096 membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 protein modifying enzyme#PC00260 HUMAN|HGNC=44370|UniProtKB=F2Z398 F2Z398 LMO7DN PTHR12138:SF156 PRIMATE-EXPANDED PROTEIN FAMILY LMO7 DOWNSTREAM NEIGHBOR PROTEIN HUMAN|HGNC=23623|UniProtKB=Q8TDV2 Q8TDV2 GPR148 PTHR26451:SF928 G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN G PROTEIN-COUPLED RECEPTOR 148-RELATED transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;binding#GO:0005488;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 sensory perception#GO:0007600;nervous system process#GO:0050877;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;detection of chemical stimulus#GO:0009593;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;response to stimulus#GO:0050896;response to chemical#GO:0042221;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501 cellular anatomical structure#GO:0110165;membrane#GO:0016020 G-protein coupled receptor#PC00021 HUMAN|HGNC=21531|UniProtKB=Q8N3T1 Q8N3T1 GALNT15 PTHR11675:SF36 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 15 polypeptide N-acetylgalactosaminyltransferase activity#GO:0004653;transferase activity#GO:0016740;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;acetylgalactosaminyltransferase activity#GO:0008376;glycosyltransferase activity#GO:0016757;catalytic activity, acting on a protein#GO:0140096;UDP-glycosyltransferase activity#GO:0008194 biosynthetic process#GO:0009058;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein O-linked glycosylation#GO:0006493;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 glycosyltransferase#PC00111;transferase#PC00220 HUMAN|HGNC=8704|UniProtKB=Q9Y5G7 Q9Y5G7 PCDHGA6 PTHR24028:SF107 CADHERIN-87A PROTOCADHERIN GAMMA-A6 cell adhesion#GO:0007155;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HUMAN|HGNC=12516|UniProtKB=P55089 P55089 UCN PTHR15035:SF11 CORTICOLIBERIN/UROCORTIN UROCORTIN molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;G protein-coupled receptor binding#GO:0001664;enzyme inhibitor activity#GO:0004857;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;neuropeptide receptor binding#GO:0071855;molecular function inhibitor activity#GO:0140678;hormone activity#GO:0005179;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;protein binding#GO:0005515;binding#GO:0005488;hormone receptor binding#GO:0051427;signaling receptor binding#GO:0005102 regulation of system process#GO:0044057;regulation of localization#GO:0032879;regulation of transport#GO:0051049;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;positive regulation of secretion by cell#GO:1903532;signal transduction#GO:0007165;positive regulation of transport#GO:0051050;positive regulation of biological process#GO:0048518;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;regulation of signaling#GO:0023051;positive regulation of secretion#GO:0051047;positive regulation of hormone secretion#GO:0046887;positive regulation of signaling#GO:0023056;cell communication#GO:0007154;regulation of secretion#GO:0051046;regulation of hormone secretion#GO:0046883;regulation of biological quality#GO:0065008;regulation of secretion by cell#GO:1903530;neuropeptide signaling pathway#GO:0007218;cellular response to stimulus#GO:0051716;regulation of hormone levels#GO:0010817;positive regulation of multicellular organismal process#GO:0051240;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;response to stimulus#GO:0050896;regulation of cell communication#GO:0010646;signaling#GO:0023052 cell body#GO:0044297;cellular anatomical structure#GO:0110165;neuronal cell body#GO:0043025;somatodendritic compartment#GO:0036477 peptide hormone#PC00179;intercellular signal molecule#PC00207 HUMAN|HGNC=1255|UniProtKB=O95447 O95447 LCA5L PTHR16650:SF9 C21ORF13-RELATED LEBERCILIN-LIKE PROTEIN cell projection organization#GO:0030030;microtubule-based movement#GO:0007018;intraciliary transport#GO:0042073;cellular component organization#GO:0016043;localization#GO:0051179;cellular localization#GO:0051641;cilium organization#GO:0044782;microtubule-based transport#GO:0099111;cytoskeleton-dependent intracellular transport#GO:0030705;plasma membrane bounded cell projection organization#GO:0120036;organelle organization#GO:0006996;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;microtubule-based process#GO:0007017;intracellular transport#GO:0046907;transport#GO:0006810 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;cilium#GO:0005929;membraneless organelle#GO:0043228;axoneme#GO:0005930;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ciliary plasm#GO:0097014;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232 HUMAN|HGNC=19286|UniProtKB=Q6P3W7 Q6P3W7 SCYL2 PTHR12984:SF18 SCY1-RELATED S/T PROTEIN KINASE-LIKE SCY1-LIKE PROTEIN 2 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=3309|UniProtKB=P08246 P08246 ELANE PTHR24257:SF16 CHYMOTRYPSIN-LIKE ELASTASE FAMILY MEMBER NEUTROPHIL ELASTASE catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171 cellular process#GO:0009987;immune response#GO:0006955;response to stress#GO:0006950;cell migration#GO:0016477;transport#GO:0006810;phagocytosis#GO:0006909;metabolic process#GO:0008152;leukocyte migration#GO:0050900;defense response#GO:0006952;import into cell#GO:0098657;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;endocytosis#GO:0006897;cell motility#GO:0048870;response to stimulus#GO:0050896;inflammatory response#GO:0006954;proteolysis#GO:0006508;immune system process#GO:0002376;acute inflammatory response#GO:0002526;protein metabolic process#GO:0019538;localization#GO:0051179 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 serine protease#PC00203;protease#PC00190;protein modifying enzyme#PC00260 HUMAN|HGNC=40051|UniProtKB=A6NC05 A6NC05 C5orf63 PTHR33558:SF2 GLUTAREDOXIN-LIKE PROTEIN C5ORF63 HOMOLOG GLUTAREDOXIN-LIKE PROTEIN C5ORF63 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=22474|UniProtKB=Q9UHV7 Q9UHV7 MED13 PTHR48249:SF4 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13 transcription coactivator activity#GO:0003713;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of RNA metabolic process#GO:0051252;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mediator complex#GO:0016592;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229 HUMAN|HGNC=26406|UniProtKB=Q96NL6 Q96NL6 SCLT1 PTHR35970:SF1 SODIUM CHANNEL AND CLATHRIN LINKER 1 SODIUM CHANNEL AND CLATHRIN LINKER 1 cell projection organization#GO:0030030;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782;organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;intracellular membraneless organelle#GO:0043232;centriole#GO:0005814;cellular anatomical structure#GO:0110165;organelle#GO:0043226;microtubule cytoskeleton#GO:0015630 scaffold/adaptor protein#PC00226 HUMAN|HGNC=24458|UniProtKB=O94850 O94850 DDN PTHR16757:SF1 DENDRIN DENDRIN HUMAN|HGNC=14248|UniProtKB=Q96RN5 Q96RN5 MED15 PTHR31804:SF3 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 15 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 15 nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;RNA polymerase II transcription regulator complex#GO:0090575;core mediator complex#GO:0070847;nucleus#GO:0005634 HUMAN|HGNC=13543|UniProtKB=O94823 O94823 ATP10B PTHR24092:SF79 PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE PHOSPHOLIPID-TRANSPORTING ATPASE VB intramembrane lipid carrier activity#GO:0140303;transporter activity#GO:0005215;ATPase-coupled intramembrane lipid carrier activity#GO:0140326;ATP-dependent activity#GO:0140657;lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104 regulation of biological quality#GO:0065008;localization#GO:0051179;lipid localization#GO:0010876;lipid translocation#GO:0034204;organophosphate ester transport#GO:0015748;cellular component organization#GO:0016043;regulation of membrane lipid distribution#GO:0097035;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;transport#GO:0006810;biological regulation#GO:0065007;phospholipid transport#GO:0015914;phospholipid translocation#GO:0045332;membrane organization#GO:0061024;lipid transport#GO:0006869;cellular process#GO:0009987;macromolecule localization#GO:0033036 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227;primary active transporter#PC00068 HUMAN|HGNC=359|UniProtKB=Q9NZN9 Q9NZN9 AIPL1 PTHR11242:SF2 ARYL HYDROCARBON RECEPTOR INTERACTING PROTEIN RELATED ARYL-HYDROCARBON-INTERACTING PROTEIN-LIKE 1 primary metabolic process#GO:0044238;protein modification process#GO:0036211;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;protein maturation#GO:0051604;protein folding#GO:0006457;biosynthetic process#GO:0009058;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170 cellular anatomical structure#GO:0110165;membrane#GO:0016020 chaperone#PC00072 HUMAN|HGNC=32960|UniProtKB=A6NJG2 A6NJG2 SOWAHD PTHR14491:SF8 SOSONDOWAH, ISOFORM G ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN SOWAHD HUMAN|HGNC=24245|UniProtKB=Q96MC2 Q96MC2 DRC1 PTHR21625:SF1 NYD-SP28 PROTEIN DYNEIN REGULATORY COMPLEX PROTEIN 1 cilium or flagellum-dependent cell motility#GO:0001539;axonemal dynein complex assembly#GO:0070286;microtubule bundle formation#GO:0001578;organelle assembly#GO:0070925;regulation of microtubule-based process#GO:0032886;axoneme assembly#GO:0035082;cilium organization#GO:0044782;cilium-dependent cell motility#GO:0060285;microtubule cytoskeleton organization#GO:0000226;protein-containing complex assembly#GO:0065003;regulation of biological process#GO:0050789;cilium assembly#GO:0060271;cellular component organization#GO:0016043;regulation of microtubule-based movement#GO:0060632;cell projection organization#GO:0030030;regulation of cellular process#GO:0050794;cell motility#GO:0048870;plasma membrane bounded cell projection assembly#GO:0120031;protein-containing complex organization#GO:0043933;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;cell projection assembly#GO:0030031;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607 cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;ciliary plasm#GO:0097014;organelle#GO:0043226;cilium#GO:0005929;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;axoneme#GO:0005930;membraneless organelle#GO:0043228 HUMAN|HGNC=26373|UniProtKB=Q2VWP7 Q2VWP7 PRTG PTHR10075:SF147 BASIGIN RELATED PROTOGENIN cell adhesion molecule#PC00069 HUMAN|HGNC=3535|UniProtKB=P00734 P00734 F2 PTHR24254:SF10 PROTHROMBIN PROTHROMBIN serine-type peptidase activity#GO:0008236;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252 biological regulation#GO:0065007;regulation of multicellular organismal process#GO:0051239;regulation of coagulation#GO:0050818;positive regulation of response to stimulus#GO:0048584;regulation of response to external stimulus#GO:0032101;multicellular organismal process#GO:0032501;positive regulation of biological process#GO:0048518;coagulation#GO:0050817;regulation of hemostasis#GO:1900046;cellular process#GO:0009987;regulation of response to wounding#GO:1903034;response to wounding#GO:0009611;response to stress#GO:0006950;blood coagulation#GO:0007596;platelet activation#GO:0030168;regulation of response to stimulus#GO:0048583;regulation of response to stress#GO:0080134;regulation of wound healing#GO:0061041;regulation of blood coagulation#GO:0030193;response to stimulus#GO:0050896;regulation of body fluid levels#GO:0050878;regulation of biological process#GO:0050789;positive regulation of multicellular organismal process#GO:0051240;hemostasis#GO:0007599;wound healing#GO:0042060;regulation of biological quality#GO:0065008;cell activation#GO:0001775;positive regulation of coagulation#GO:0050820 extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cellular anatomical structure#GO:0110165 protease#PC00190;serine protease#PC00203;protein modifying enzyme#PC00260 Blood coagulation#P00011>Prothrombin#P00416;Blood coagulation#P00011>Thrombin#P00414 HUMAN|HGNC=14282|UniProtKB=Q9H1B7 Q9H1B7 IRF2BPL PTHR10816:SF14 MYELIN TRANSCRIPTION FACTOR 1-RELATED E3 UBIQUITIN-PROTEIN LIGASE IRF2BPL-RELATED transcription regulator activity#GO:0140110;transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=4198|UniProtKB=O75603 O75603 GCM2 PTHR12414:SF7 GLIAL CELLS MISSING RELATED/GLIDE CHORION-SPECIFIC TRANSCRIPTION FACTOR GCMB sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 animal gross anatomical part developmental process#GO:0160108;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;developmental process#GO:0032502;multicellular organism development#GO:0007275;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;gliogenesis#GO:0042063;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;nervous system development#GO:0007399 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=23805|UniProtKB=Q76L83 Q76L83 ASXL2 PTHR13578:SF11 ADDITIONAL SEX COMBS LIKE PROTEIN ASXL POLYCOMB GROUP PROTEIN ASXL2-RELATED protein binding#GO:0005515;chromatin binding#GO:0003682;binding#GO:0005488;signaling receptor binding#GO:0005102 regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;animal organ development#GO:0048513;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of transcription by RNA polymerase II#GO:0045944;developmental process#GO:0032502;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;animal organ morphogenesis#GO:0009887;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of RNA metabolic process#GO:0051252;animal gross anatomical part developmental process#GO:0160108 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;PcG protein complex#GO:0031519;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=32225|UniProtKB=Q9Y4P8 Q9Y4P8 WIPI2 PTHR11227:SF27 WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED WD REPEAT DOMAIN PHOSPHOINOSITIDE-INTERACTING PROTEIN 2 phosphatidylinositol-3-phosphate binding#GO:0032266;phosphatidylinositol phosphate binding#GO:1901981;molecular adaptor activity#GO:0060090;phospholipid binding#GO:0005543;lipid binding#GO:0008289;phosphatidylinositol bisphosphate binding#GO:1902936;protein-macromolecule adaptor activity#GO:0030674;ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;binding#GO:0005488 cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;autophagosome organization#GO:1905037;cellular process#GO:0009987;autophagy#GO:0006914;cellular component organization or biogenesis#GO:0071840;autophagosome assembly#GO:0000045;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;polysaccharide metabolic process#GO:0005976;glucan catabolic process#GO:0009251;glucan metabolic process#GO:0044042;cellular component organization#GO:0016043;polysaccharide catabolic process#GO:0000272;carbohydrate catabolic process#GO:0016052;process utilizing autophagic mechanism#GO:0061919;macroautophagy#GO:0016236;glycogen catabolic process#GO:0005980;macromolecule localization#GO:0033036;energy derivation by oxidation of organic compounds#GO:0015980;pexophagy#GO:0000425;macromolecule metabolic process#GO:0043170;intracellular protein localization#GO:0008104;autophagy of mitochondrion#GO:0000422;generation of precursor metabolites and energy#GO:0006091;catabolic process#GO:0009056;carbohydrate metabolic process#GO:0005975;primary metabolic process#GO:0044238;glycogen metabolic process#GO:0005977;localization#GO:0051179;vacuole organization#GO:0007033;energy reserve metabolic process#GO:0006112;organelle assembly#GO:0070925 membrane#GO:0016020;phagophore assembly site#GO:0000407;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 scaffold/adaptor protein#PC00226 HUMAN|HGNC=29644|UniProtKB=Q9NZC3 Q9NZC3 GDE1 PTHR46320:SF1 GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE 1 GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE 1 hydrolase activity#GO:0016787;phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 alcohol metabolic process#GO:0006066;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;amine metabolic process#GO:0009308;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;small molecule metabolic process#GO:0044281;phospholipid metabolic process#GO:0006644 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 hydrolase#PC00121;phosphodiesterase#PC00185 HUMAN|HGNC=6825|UniProtKB=P49641 P49641 MAN2A2 PTHR11607:SF57 ALPHA-MANNOSIDASE ALPHA-MANNOSIDASE 2X hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553 glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;glycoprotein biosynthetic process#GO:0009101;protein N-linked glycosylation#GO:0006487;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058 Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 hydrolase#PC00121;glycosidase#PC00110 HUMAN|HGNC=27124|UniProtKB=Q96N38 Q96N38 ZNF714 PTHR24384:SF104 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED ZINC FINGER PROTEIN 714 cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218 HUMAN|HGNC=24369|UniProtKB=Q9Y536 Q9Y536 PPIAL4A PTHR11071:SF450 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A-LIKE 4A membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 chaperone#PC00072 HUMAN|HGNC=28264|UniProtKB=Q86SE9 Q86SE9 PCGF5 PTHR45893:SF1 POLYCOMB GROUP RING FINGER PROTEIN POLYCOMB GROUP RING FINGER PROTEIN 5 regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;heterochromatin formation#GO:0031507;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;epigenetic regulation of gene expression#GO:0040029;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;cellular component assembly#GO:0022607;heterochromatin organization#GO:0070828;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;negative regulation of gene expression, epigenetic#GO:0045814 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;PcG protein complex#GO:0031519;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 chromatin/chromatin-binding, or -regulatory protein#PC00077;histone modifying enzyme#PC00261 HUMAN|HGNC=25405|UniProtKB=Q6ZUS6 Q6ZUS6 CCDC149 PTHR21682:SF2 COILED-COIL DOMAIN-CONTAINING PROTEIN 149 COILED-COIL DOMAIN-CONTAINING PROTEIN 149 HUMAN|HGNC=23470|UniProtKB=A6NFZ4 A6NFZ4 FAM24A PTHR35860:SF1 PROTEIN FAM24B PROTEIN FAM24A HUMAN|HGNC=11158|UniProtKB=P62314 P62314 SNRPD1 PTHR23338:SF18 SMALL NUCLEAR RIBONUCLEOPROTEIN SM SMALL NUCLEAR RIBONUCLEOPROTEIN SM D1 nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;cellular component biogenesis#GO:0044085;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;cellular component assembly#GO:0022607;gene expression#GO:0010467;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;protein-containing complex organization#GO:0043933;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;protein-RNA complex organization#GO:0071826;protein-containing complex assembly#GO:0065003;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;ribonucleoprotein complex biogenesis#GO:0022613;spliceosomal snRNP assembly#GO:0000387;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA metabolic process#GO:0016070;protein-RNA complex assembly#GO:0022618;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377 spliceosomal tri-snRNP complex#GO:0097526;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;precatalytic spliceosome#GO:0071011;SMN-Sm protein complex#GO:0034719;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;spliceosomal snRNP complex#GO:0097525;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;U4 snRNP#GO:0005687;U2-type spliceosomal complex#GO:0005684;cellular anatomical structure#GO:0110165;organelle#GO:0043226;U2 snRNP#GO:0005686;catalytic step 2 spliceosome#GO:0071013;Sm-like protein family complex#GO:0120114;U5 snRNP#GO:0005682;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;small nuclear ribonucleoprotein complex#GO:0030532;cytoplasm#GO:0005737;U1 snRNP#GO:0005685;protein-containing complex#GO:0032991 RNA splicing factor#PC00148;RNA metabolism protein#PC00031;RNA processing factor#PC00147 HUMAN|HGNC=1307|UniProtKB=Q9Y3M2 Q9Y3M2 CBY1 PTHR21533:SF20 LEUCINE-RICH PROTEIN PROTEIN CHIBBY HOMOLOG 1 negative regulation of cell communication#GO:0010648;negative regulation of cellular process#GO:0048523;negative regulation of signaling#GO:0023057;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;regulation of cellular process#GO:0050794;negative regulation of response to stimulus#GO:0048585;negative regulation of Wnt signaling pathway#GO:0030178;regulation of cell communication#GO:0010646;negative regulation of signal transduction#GO:0009968;regulation of Wnt signaling pathway#GO:0030111;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=21581|UniProtKB=Q5VZK9 Q5VZK9 CARMIL1 PTHR24112:SF39 LEUCINE-RICH REPEAT, ISOFORM F-RELATED F-ACTIN-UNCAPPING PROTEIN LRRC16A regulation of actin filament-based process#GO:0032970;regulation of actin nucleation#GO:0051125;regulation of organelle organization#GO:0033043;regulation of actin filament organization#GO:0110053;cellular process#GO:0009987;regulation of supramolecular fiber organization#GO:1902903;regulation of biological process#GO:0050789;regulation of actin cytoskeleton organization#GO:0032956;biological regulation#GO:0065007;cell migration#GO:0016477;regulation of cellular process#GO:0050794;cell motility#GO:0048870;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493 plasma membrane#GO:0005886;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;lamellipodium#GO:0030027;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;cell leading edge#GO:0031252;membrane#GO:0016020 protein-binding activity modulator#PC00095 HUMAN|HGNC=23138|UniProtKB=Q9ULK6 Q9ULK6 RNF150 PTHR22765:SF42 RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING RING FINGER PROTEIN 150 catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=16451|UniProtKB=P0DN87 P0DN87 CGB7 PTHR11515:SF25 GLYCOPROTEIN HORMONE BETA CHAIN CHORIOGONADOTROPIN SUBUNIT BETA 3-RELATED molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;hormone activity#GO:0005179;molecular function activator activity#GO:0140677;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018 multicellular organism development#GO:0007275;animal organ development#GO:0048513;development of primary sexual characteristics#GO:0045137;developmental process#GO:0032502;biological regulation#GO:0065007;gonad development#GO:0008406;multicellular organismal process#GO:0032501;signal transduction#GO:0007165;cellular process#GO:0009987;sex differentiation#GO:0007548;system development#GO:0048731;female gonad development#GO:0008585;reproductive system development#GO:0061458;cell communication#GO:0007154;anatomical structure development#GO:0048856;G protein-coupled receptor signaling pathway#GO:0007186;animal gross anatomical part developmental process#GO:0160108;signaling#GO:0023052;reproductive process#GO:0022414;reproductive structure development#GO:0048608;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;developmental process involved in reproduction#GO:0003006 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 peptide hormone#PC00179 HUMAN|HGNC=621|UniProtKB=Q13564 Q13564 NAE1 PTHR10953:SF29 UBIQUITIN-ACTIVATING ENZYME E1 NEDD8-ACTIVATING ENZYME E1 REGULATORY SUBUNIT ATP-dependent activity#GO:0140657;ligase activity, forming carbon-sulfur bonds#GO:0016877;transferase activity, transferring sulphur-containing groups#GO:0016782;sulfurtransferase activity#GO:0016783;thiosulfate-cyanide sulfurtransferase activity#GO:0004792;transferase activity, transferring phosphorus-containing groups#GO:0016772;ubiquitin-like modifier activating enzyme activity#GO:0008641;ligase activity#GO:0016874;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a protein#GO:0140096 cellular process#GO:0009987;protein modification by small protein conjugation#GO:0032446;protein modification process#GO:0036211;primary metabolic process#GO:0044238;post-translational protein modification#GO:0043687;metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=10429|UniProtKB=P62753 P62753 RPS6 PTHR11502:SF34 40S RIBOSOMAL PROTEIN S6 SMALL RIBOSOMAL SUBUNIT PROTEIN ES6 ribosomal protein#PC00202 CCKR signaling map#P06959>RPS6#P07143 HUMAN|HGNC=5767|UniProtKB=A0A075B7D4 A0A075B7D4 IGKV1OR2-108 PTHR23267:SF376 IMMUNOGLOBULIN LIGHT CHAIN IG-LIKE DOMAIN-CONTAINING PROTEIN response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=29456|UniProtKB=Q5JTV8 Q5JTV8 TOR1AIP1 PTHR18843:SF6 TORSIN-1A-INTERACTING PROTEIN TORSIN-1A-INTERACTING PROTEIN 1 nuclear envelope organization#GO:0006998;nucleus organization#GO:0006997;cellular component organization or biogenesis#GO:0071840;membrane organization#GO:0061024;endomembrane system organization#GO:0010256;nuclear membrane organization#GO:0071763;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996 nucleus#GO:0005634;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;nuclear membrane#GO:0031965;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=16800|UniProtKB=Q685J3 Q685J3 MUC17 PTHR37999:SF2 MUCIN-17 MUCIN-17 HUMAN|HGNC=6349|UniProtKB=Q13887 Q13887 KLF5 PTHR23235:SF82 KRUEPPEL-LIKE TRANSCRIPTION FACTOR KRUEPPEL-LIKE FACTOR 5 cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=30023|UniProtKB=Q8WW12 Q8WW12 PCNP PTHR16523:SF8 PEST PROTEOLYTIC SIGNAL-CONTAINING NUCLEAR PROTEIN PEST PROTEOLYTIC SIGNAL-CONTAINING NUCLEAR PROTEIN modification-dependent protein catabolic process#GO:0019941;protein modification by small protein conjugation#GO:0032446;protein modification process#GO:0036211;primary metabolic process#GO:0044238;catabolic process#GO:0009056;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein modification by small protein conjugation or removal#GO:0070647;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;cellular process#GO:0009987;protein ubiquitination#GO:0016567;proteasomal protein catabolic process#GO:0010498;post-translational protein modification#GO:0043687;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=3391|UniProtKB=P29322 P29322 EPHA8 PTHR46877:SF7 EPH RECEPTOR A5 EPHRIN TYPE-A RECEPTOR 8 molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888;catalytic activity, acting on a protein#GO:0140096;transmembrane receptor protein kinase activity#GO:0019199;signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 cellular developmental process#GO:0048869;neurogenesis#GO:0022008;neuron projection guidance#GO:0097485;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;axon development#GO:0061564;axon guidance#GO:0007411;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;system development#GO:0048731;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;ephrin receptor signaling pathway#GO:0048013;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cell projection morphogenesis#GO:0048858;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell surface receptor signaling pathway#GO:0007166;neuron differentiation#GO:0030182;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;neuron projection development#GO:0031175;cellular process#GO:0009987;signal transduction#GO:0007165;axonogenesis#GO:0007409;neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;cell differentiation#GO:0030154;response to stimulus#GO:0050896;cell development#GO:0048468;signaling#GO:0023052;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653 membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;somatodendritic compartment#GO:0036477;cell projection#GO:0042995;plasma membrane#GO:0005886;plasma membrane bounded cell projection#GO:0120025;dendrite#GO:0030425;dendritic tree#GO:0097447 transmembrane signal receptor#PC00197 HUMAN|HGNC=18893|UniProtKB=Q8N5I3 Q8N5I3 KCNRG PTHR14499:SF5 POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING POTASSIUM CHANNEL REGULATORY PROTEIN protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 scaffold/adaptor protein#PC00226 HUMAN|HGNC=17961|UniProtKB=Q7Z2W7 Q7Z2W7 TRPM8 PTHR13800:SF9 TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6 TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 8 ligand-gated calcium channel activity#GO:0099604;calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;gated channel activity#GO:0022836;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;ligand-gated monoatomic cation channel activity#GO:0099094;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803 metal ion transport#GO:0030001;calcium ion transmembrane transport#GO:0070588;regulation of biological process#GO:0050789;positive regulation of multicellular organismal process#GO:0051240;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;sensory perception#GO:0007600;nervous system process#GO:0050877;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;monoatomic cation transmembrane transport#GO:0098655;regulation of multicellular organismal process#GO:0051239;monoatomic ion transmembrane transport#GO:0034220;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;establishment of localization#GO:0051234;system process#GO:0003008;calcium ion transport#GO:0006816;transport#GO:0006810 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133;transporter#PC00227 HUMAN|HGNC=32406|UniProtKB=Q1A5X6 Q1A5X6 IQCJ PTHR35976:SF1 IQ DOMAIN-CONTAINING PROTEIN J IQ DOMAIN-CONTAINING PROTEIN J HUMAN|HGNC=28119|UniProtKB=Q4G0F5 Q4G0F5 VPS26B PTHR12233:SF5 VACUOLAR PROTEIN SORTING 26 RELATED VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 26B establishment of localization#GO:0051234;endosomal transport#GO:0016197;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;transport#GO:0006810;intracellular protein transport#GO:0006886;vesicle-mediated transport#GO:0016192;macromolecule localization#GO:0033036;retrograde transport, endosome to Golgi#GO:0042147;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular localization#GO:0051641;localization#GO:0051179;protein transport#GO:0015031;cytosolic transport#GO:0016482 membrane#GO:0016020;cytoplasm#GO:0005737;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;vesicle#GO:0031982;retromer complex#GO:0030904;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 membrane traffic protein#PC00150 HUMAN|HGNC=18267|UniProtKB=Q96PY5 Q96PY5 FMNL2 PTHR45857:SF5 FORMIN-LIKE PROTEIN FORMIN-LIKE PROTEIN 2 actin filament binding#GO:0051015;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;binding#GO:0005488;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 cellular process#GO:0009987;cell migration#GO:0016477;cell motility#GO:0048870 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 HUMAN|HGNC=24821|UniProtKB=Q8WZ73 Q8WZ73 RFFL PTHR14879:SF2 CASPASE REGULATOR, RING FINGER DOMAIN-CONTAINING E3 UBIQUITIN-PROTEIN LIGASE RIFIFYLIN catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842 regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;negative regulation of extrinsic apoptotic signaling pathway#GO:2001237;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of apoptotic process#GO:0043066;negative regulation of response to stimulus#GO:0048585;negative regulation of apoptotic signaling pathway#GO:2001234;regulation of apoptotic signaling pathway#GO:2001233;protein metabolic process#GO:0019538;modification-dependent protein catabolic process#GO:0019941;regulation of extrinsic apoptotic signaling pathway#GO:2001236;primary metabolic process#GO:0044238;regulation of cell communication#GO:0010646;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;regulation of apoptotic process#GO:0042981;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;negative regulation of programmed cell death#GO:0043069;cellular process#GO:0009987;negative regulation of signal transduction#GO:0009968;proteasomal protein catabolic process#GO:0010498;protein catabolic process#GO:0030163;regulation of signaling#GO:0023051;modification-dependent macromolecule catabolic process#GO:0043632;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067 cell periphery#GO:0071944;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=29251|UniProtKB=Q9P2K9 Q9P2K9 DISP3 PTHR46687:SF1 PROTEIN DISPATCHED HOMOLOG 3 PROTEIN DISPATCHED HOMOLOG 3 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=42972|UniProtKB=A6NJI9 A6NJI9 LRRC72 PTHR46759:SF1 LEUCINE-RICH REPEAT-CONTAINING PROTEIN 72 LEUCINE-RICH REPEAT-CONTAINING PROTEIN 72 HUMAN|HGNC=17361|UniProtKB=Q03989 Q03989 ARID5A PTHR13964:SF25 RBP-RELATED AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 5A sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 transcription cofactor#PC00217 HUMAN|HGNC=20250|UniProtKB=Q96IF1 Q96IF1 AJUBA PTHR24219:SF7 LIM DOMAIN-CONTAINING PROTEIN JUB LIM DOMAIN-CONTAINING PROTEIN AJUBA transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714 regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;negative regulation of protein metabolic process#GO:0051248;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;post-transcriptional gene silencing#GO:0016441;regulatory ncRNA-mediated post-transcriptional gene silencing#GO:0035194;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of response to stimulus#GO:0048585;negative regulation of biosynthetic process#GO:0009890;regulation of signal transduction#GO:0009966;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;regulatory ncRNA-mediated gene silencing#GO:0031047;regulation of response to stimulus#GO:0048583;negative regulation of metabolic process#GO:0009892;regulation of hippo signaling#GO:0035330;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;miRNA-mediated post-transcriptional gene silencing#GO:0035195;regulation of biological process#GO:0050789;negative regulation of hippo signaling#GO:0035331;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;negative regulation of translation#GO:0017148;regulation of signaling#GO:0023051;negative regulation of signal transduction#GO:0009968;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of protein metabolic process#GO:0051246;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253 supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cell-cell junction#GO:0005911;nucleus#GO:0005634;membraneless organelle#GO:0043228;cell junction#GO:0030054;adherens junction#GO:0005912;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;membrane-bounded organelle#GO:0043227;P-body#GO:0000932;intracellular organelle#GO:0043229 transcription cofactor#PC00217;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=16611|UniProtKB=Q5T7P3 Q5T7P3 LCE1B PTHR48615:SF1 LATE CORNIFIED ENVELOPE PROTEIN 1C LATE CORNIFIED ENVELOPE PROTEIN 1B HUMAN|HGNC=6189|UniProtKB=Q9Y219 Q9Y219 JAG2 PTHR24044:SF421 NOTCH LIGAND FAMILY MEMBER PROTEIN JAGGED-2 binding#GO:0005488;signaling receptor binding#GO:0005102;protein binding#GO:0005515 intercellular signal molecule#PC00207 Notch signaling pathway#P00045>Next#P01103;Angiogenesis#P00005>Delta/Serrate#P00226;Notch signaling pathway#P00045>Serrate#P01104 HUMAN|HGNC=18583|UniProtKB=Q9ULR3 Q9ULR3 PPM1H PTHR13832:SF287 PROTEIN PHOSPHATASE 2C PROTEIN PHOSPHATASE 1H hydrolase activity#GO:0016787;protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cell communication#GO:0007154 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 protein phosphatase#PC00195 HUMAN|HGNC=7978|UniProtKB=P04150 P04150 NR3C1 PTHR48092:SF5 KNIRPS-RELATED PROTEIN-RELATED GLUCOCORTICOID RECEPTOR sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023;transcription regulator activity#GO:0140110;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;molecular transducer activity#GO:0060089;nuclear receptor activity#GO:0004879;DNA binding#GO:0003677 hormone-mediated signaling pathway#GO:0009755;cellular response to chemical stimulus#GO:0070887;regulation of transcription by RNA polymerase II#GO:0006357;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;cellular response to hormone stimulus#GO:0032870;signaling#GO:0023052;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;cellular response to steroid hormone stimulus#GO:0071383;response to chemical#GO:0042221;cellular response to lipid#GO:0071396;response to lipid#GO:0033993;response to hormone#GO:0009725;signal transduction#GO:0007165;cellular process#GO:0009987;cell communication#GO:0007154;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;intracellular signal transduction#GO:0035556;response to steroid hormone#GO:0048545;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;intracellular receptor signaling pathway#GO:0030522;steroid hormone receptor signaling pathway#GO:0043401;cellular response to stimulus#GO:0051716;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of nucleobase-containing compound metabolic process#GO:0019219;nuclear receptor-mediated signaling pathway#GO:0141193;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;nuclear receptor-mediated steroid hormone signaling pathway#GO:0030518 intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;chromosome#GO:0005694;chromatin#GO:0000785;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232 C4 zinc finger nuclear receptor#PC00169;zinc finger transcription factor#PC00244 Gonadotropin-releasing hormone receptor pathway#P06664>GR#P06810 HUMAN|HGNC=25287|UniProtKB=Q68DH5 Q68DH5 LMBRD2 PTHR21355:SF19 G-PROTEIN COUPLED RECEPTOR-ASSOCIATED PROTEIN LMBRD2 G PROTEIN-COUPLED RECEPTOR-ASSOCIATED PROTEIN LMBRD2 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;adrenergic receptor signaling pathway#GO:0071875;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;membrane#GO:0016020 HUMAN|HGNC=20570|UniProtKB=Q96S94 Q96S94 CCNL2 PTHR10026:SF45 CYCLIN CYCLIN-L2 molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;protein kinase regulator activity#GO:0019887;cyclin-dependent protein kinase regulator activity#GO:0019914;enzyme regulator activity#GO:0030234;cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 kinase modulator#PC00140;kinase activator#PC00138 HUMAN|HGNC=17389|UniProtKB=Q92484 Q92484 SMPDL3A PTHR10340:SF24 SPHINGOMYELIN PHOSPHODIESTERASE CYCLIC GMP-AMP PHOSPHODIESTERASE SMPDL3A hydrolase activity#GO:0016787;phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 hydrolase#PC00121;phosphodiesterase#PC00185 HUMAN|HGNC=13636|UniProtKB=Q9HBA9 Q9HBA9 FOLH1B PTHR10404:SF36 N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE GLUTAMATE CARBOXYPEPTIDASE 2-RELATED catalytic activity, acting on a protein#GO:0140096;exopeptidase activity#GO:0008238;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;carboxypeptidase activity#GO:0004180;catalytic activity#GO:0003824 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 metalloprotease#PC00153 HUMAN|HGNC=20485|UniProtKB=O75317 O75317 USP12 PTHR24006:SF647 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 12 cysteine-type peptidase activity#GO:0008234;cysteine-type deubiquitinase activity#GO:0004843;catalytic activity#GO:0003824;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787 regulation of protein stability#GO:0031647;regulation of biological quality#GO:0065008;biological regulation#GO:0065007 cytosol#GO:0005829;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 protease#PC00190;cysteine protease#PC00081 HUMAN|HGNC=26262|UniProtKB=Q6NXR4 Q6NXR4 TTI2 PTHR32226:SF2 TELO2-INTERACTING PROTEIN 2 TELO2-INTERACTING PROTEIN 2 protein-containing complex#GO:0032991 HUMAN|HGNC=18527|UniProtKB=Q2M2I5 Q2M2I5 KRT24 PTHR23239:SF207 INTERMEDIATE FILAMENT KERATIN, TYPE I CYTOSKELETAL 24 structural molecule activity#GO:0005198 intermediate filament cytoskeleton organization#GO:0045104;cell differentiation#GO:0030154;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;tissue morphogenesis#GO:0048729;supramolecular fiber organization#GO:0097435;animal gross anatomical part developmental process#GO:0160108;intermediate filament-based process#GO:0045103;intermediate filament organization#GO:0045109;tissue development#GO:0009888;epithelial cell differentiation#GO:0030855;epithelium development#GO:0060429;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular process#GO:0009987;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;morphogenesis of an epithelium#GO:0002009;developmental process#GO:0032502 intermediate filament#GO:0005882;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;supramolecular complex#GO:0099080;organelle#GO:0043226;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165 intermediate filament#PC00129 HUMAN|HGNC=15781|UniProtKB=Q494W8 Q494W8 CHRFAM7A PTHR18945:SF902 NEUROTRANSMITTER GATED ION CHANNEL CHRNA7-FAM7A FUSION PROTEIN channel activity#GO:0015267;molecular transducer activity#GO:0060089;ligand-gated monoatomic ion channel activity#GO:0015276;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;monoatomic cation transmembrane transporter activity#GO:0008324;postsynaptic neurotransmitter receptor activity#GO:0098960;gated channel activity#GO:0022836;signaling receptor activity#GO:0038023;monoatomic ion channel activity#GO:0005216;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;neurotransmitter receptor activity#GO:0030594 monoatomic cation transport#GO:0006812;cell communication#GO:0007154;localization#GO:0051179;transmembrane transport#GO:0055085;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;trans-synaptic signaling#GO:0099537;anterograde trans-synaptic signaling#GO:0098916;signaling#GO:0023052;metal ion transport#GO:0030001;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;calcium ion transport#GO:0006816;transport#GO:0006810;synaptic transmission, cholinergic#GO:0007271;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;monoatomic ion transmembrane transport#GO:0034220;synaptic signaling#GO:0099536;cellular process#GO:0009987 plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;neuronal cell body#GO:0043025;cellular anatomical structure#GO:0110165;synapse#GO:0045202;plasma membrane protein complex#GO:0098797;cell body#GO:0044297;postsynapse#GO:0098794;membrane protein complex#GO:0098796;transmembrane transporter complex#GO:1902495;axon#GO:0030424;postsynaptic membrane#GO:0045211;presynaptic membrane#GO:0042734;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane region#GO:0098590;cell periphery#GO:0071944;presynapse#GO:0098793;neuron projection#GO:0043005;membrane#GO:0016020;transporter complex#GO:1990351;cell junction#GO:0030054;synaptic membrane#GO:0097060;signaling receptor complex#GO:0043235 ligand-gated ion channel#PC00141 Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086;Nicotinic acetylcholine receptor signaling pathway#P00044>alpha#P01088;Alzheimer disease-amyloid secretase pathway#P00003>alpha7 nicotinic acetylcholine receptor#P00079 HUMAN|HGNC=11762|UniProtKB=Q9UP52 Q9UP52 TFR2 PTHR10404:SF33 N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE TRANSFERRIN RECEPTOR PROTEIN 2 peptidase activity#GO:0008233;carboxypeptidase activity#GO:0004180;catalytic activity, acting on a protein#GO:0140096;exopeptidase activity#GO:0008238;hydrolase activity#GO:0016787;catalytic activity#GO:0003824 metalloprotease#PC00153 HUMAN|HGNC=28594|UniProtKB=Q8NEG0 Q8NEG0 GARIN6 PTHR22574:SF11 FAMILY NOT NAMED GOLGI-ASSOCIATED RAB2 INTERACTOR PROTEIN 6 HUMAN|HGNC=12820|UniProtKB=Q9GZR2 Q9GZR2 REXO4 PTHR12801:SF130 RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED RNA EXONUCLEASE 4 hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on a nucleic acid#GO:0140640;exonuclease activity#GO:0004527;catalytic activity#GO:0003824;nuclease activity#GO:0004518;hydrolase activity#GO:0016787 gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;nucleobase-containing compound catabolic process#GO:0034655;cellular process#GO:0009987;nucleic acid catabolic process#GO:0141188;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;DNA metabolic process#GO:0006259;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;catabolic process#GO:0009056;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA metabolic process#GO:0016070;DNA catabolic process#GO:0006308;nucleic acid biosynthetic process#GO:0141187 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 exoribonuclease#PC00099;RNA metabolism protein#PC00031 HUMAN|HGNC=21361|UniProtKB=Q5TGL8 Q5TGL8 PXDC1 PTHR31433:SF0 PX DOMAIN-CONTAINING PROTEIN 1 PX DOMAIN-CONTAINING PROTEIN 1 HUMAN|HGNC=29646|UniProtKB=Q8TBR7 Q8TBR7 TLCD3A PTHR13439:SF20 CT120 PROTEIN TLC DOMAIN-CONTAINING PROTEIN 3A chemical homeostasis#GO:0048878;lipid homeostasis#GO:0055088;homeostatic process#GO:0042592 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 transferase#PC00220;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=14759|UniProtKB=Q8NGJ5 Q8NGJ5 OR51L1 PTHR26450:SF37 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 51L1 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=4407|UniProtKB=P50150 P50150 GNG4 PTHR13809:SF21 GUANINE NUCLEOTIDE-BINDING PROTEIN GAMMA SUBUNIT GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)_G(S)_G(O) SUBUNIT GAMMA-4 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;molecular function regulator activity#GO:0098772 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 cytoplasmic side of membrane#GO:0098562;extrinsic component of cytoplasmic side of plasma membrane#GO:0031234;catalytic complex#GO:1902494;side of membrane#GO:0098552;extrinsic component of plasma membrane#GO:0019897;extrinsic component of membrane#GO:0019898;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane#GO:0016020;cytoplasmic side of plasma membrane#GO:0009898;membrane protein complex#GO:0098796;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 heterotrimeric G-protein#PC00117 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Gbetagamma#P00836;Angiotensin II-stimulated signaling through G proteins and beta-arrestin#P05911>Ggamma#P05929;Enkephalin release#P05913>G-Protein (s)#P05977;Enkephalin release#P05913>G-Protein (i)#P05974;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Ggamma#P00751;5HT2 type receptor mediated signaling pathway#P04374>G-protein#P04416;Thyrotropin-releasing hormone receptor signaling pathway#P04394>G-Protein#P04584;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>G-Protein#P01085;Cortocotropin releasing factor receptor signaling pathway#P04380>G-Protein#P04458;Oxytocin receptor mediated signaling pathway#P04391>G-Protein#P04534;Opioid proopiomelanocortin pathway#P05917>G-protein#P06012;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>G-Protein#P01073;5HT4 type receptor mediated signaling pathway#P04376>G-protein#P04430;Metabotropic glutamate receptor group III pathway#P00039>G-Protein#P01045;Endogenous cannabinoid signaling#P05730>Ggamma#P05744;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GIRK#P00743;Wnt signaling pathway#P00057>Ggamma#P01465;Metabotropic glutamate receptor group II pathway#P00040>G-protein#P01047;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Ggamma#P00726;Beta1 adrenergic receptor signaling pathway#P04377>G-Protein#P04436;Opioid prodynorphin pathway#P05916>G-protein#P06002;Beta3 adrenergic receptor signaling pathway#P04379>G-Protein#P04448;GABA-B receptor II signaling#P05731>Ggamma#P05754;5HT1 type receptor mediated signaling pathway#P04373>G-protein#P04408;Opioid proenkephalin pathway#P05915>G-protein#P05994;Histamine H1 receptor mediated signaling pathway#P04385>G-Protein#P04488;Beta2 adrenergic receptor signaling pathway#P04378>G-Protein#P04443;Histamine H2 receptor mediated signaling pathway#P04386>G-Protein#P04490;Dopamine receptor mediated signaling pathway#P05912>Ggamma#P05967;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Ggamma#P00721 HUMAN|HGNC=7714|UniProtKB=O75251 O75251 NDUFS7 PTHR11995:SF22 NADH DEHYDROGENASE NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 7, MITOCHONDRIAL NADH dehydrogenase activity#GO:0003954;monoatomic cation transmembrane transporter activity#GO:0008324;oxidoreductase activity, acting on NAD(P)H#GO:0016651;electron transfer activity#GO:0009055;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;proton transmembrane transporter activity#GO:0015078;catalytic activity#GO:0003824;active transmembrane transporter activity#GO:0022804;oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor#GO:0016655;primary active transmembrane transporter activity#GO:0015399;oxidoreductase activity#GO:0016491;monoatomic ion transmembrane transporter activity#GO:0015075 monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987;monoatomic cation transport#GO:0006812;localization#GO:0051179;proton transmembrane transport#GO:1902600;cellular respiration#GO:0045333;energy derivation by oxidation of organic compounds#GO:0015980;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;aerobic respiration#GO:0009060;monoatomic ion transport#GO:0006811;metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091;transport#GO:0006810 respiratory chain complex I#GO:0045271;catalytic complex#GO:1902494;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;membrane#GO:0016020;oxidoreductase complex#GO:1990204;membrane protein complex#GO:0098796;respiratory chain complex#GO:0098803;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 oxidoreductase#PC00176;dehydrogenase#PC00092 HUMAN|HGNC=6210|UniProtKB=P27701 P27701 CD82 PTHR19282:SF44 TETRASPANIN CD82 ANTIGEN cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 p53 pathway#P00059>KAI#G04704 HUMAN|HGNC=6761|UniProtKB=Q05195 Q05195 MXD1 PTHR11969:SF18 MAX DIMERIZATION, MAD MAX DIMERIZATION PROTEIN 1 nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 basic helix-loop-helix transcription factor#PC00055;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=5217|UniProtKB=P14060 P14060 HSD3B1 PTHR10366:SF364 NAD DEPENDENT EPIMERASE/DEHYDRATASE 3 BETA-HYDROXYSTEROID DEHYDROGENASE_DELTA 5--4-ISOMERASE TYPE 1 catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614 metabolic process#GO:0008152;lipid metabolic process#GO:0006629;steroid biosynthetic process#GO:0006694;regulation of biological quality#GO:0065008;primary metabolic process#GO:0044238;regulation of hormone levels#GO:0010817;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;hormone metabolic process#GO:0042445;biosynthetic process#GO:0009058;biological regulation#GO:0065007;steroid metabolic process#GO:0008202 intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 dehydratase#PC00091;lyase#PC00144;metabolite interconversion enzyme#PC00262 Androgen/estrogene/progesterone biosynthesis#P02727>3beta-Hydroxysteroid dehydrogenase#P02833 HUMAN|HGNC=12197|UniProtKB=A0A075B6H5 A0A075B6H5 TRBV20OR9-2 PTHR23268:SF130 T-CELL RECEPTOR BETA CHAIN T CELL RECEPTOR BETA VARIABLE 20-1 cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=12135|UniProtKB=A0A075B6V5 A0A075B6V5 TRAV36DV7 PTHR19433:SF83 T-CELL RECEPTOR ALPHA CHAIN V REGION-RELATED T CELL RECEPTOR ALPHA VARIABLE 36_DELTA VARIABLE 7 response to biotic stimulus#GO:0009607;response to bacterium#GO:0009617;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to external stimulus#GO:0009605;response to other organism#GO:0051707;response to stimulus#GO:0050896 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=8079|UniProtKB=Q6ZUT3 Q6ZUT3 FRMD7 PTHR45858:SF1 FERM DOMAIN CONTAINING PROTEIN FERM DOMAIN-CONTAINING PROTEIN 7 molecular function regulator activity#GO:0098772;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;guanyl-nucleotide exchange factor activity#GO:0005085 regulation of cell projection organization#GO:0031344;regulation of neuron projection development#GO:0010975;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of cellular component organization#GO:0051128;biological regulation#GO:0065007 HUMAN|HGNC=29125|UniProtKB=Q9UQ16 Q9UQ16 DNM3 PTHR11566:SF54 DYNAMIN DYNAMIN-3 ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;tubulin binding#GO:0015631;hydrolase activity, acting on acid anhydrides#GO:0016817;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;GTPase activity#GO:0003924;microtubule binding#GO:0008017 cellular localization#GO:0051641;localization#GO:0051179;organelle localization#GO:0051640;establishment of organelle localization#GO:0051656;endocytosis#GO:0006897;cellular component organization#GO:0016043;synaptic vesicle endocytosis#GO:0048488;vesicle-mediated transport in synapse#GO:0099003;establishment of localization#GO:0051234;import into cell#GO:0098657;cellular component organization or biogenesis#GO:0071840;vesicle organization#GO:0016050;vesicle budding from membrane#GO:0006900;transport#GO:0006810;synaptic vesicle cycle#GO:0099504;vesicle-mediated transport#GO:0016192;synaptic vesicle localization#GO:0097479;synaptic vesicle recycling#GO:0036465;establishment of vesicle localization#GO:0051650;membrane organization#GO:0061024;synaptic vesicle transport#GO:0048489;organelle organization#GO:0006996;cellular process#GO:0009987;vesicle localization#GO:0051648;establishment of localization in cell#GO:0051649 cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cell junction#GO:0030054;membrane#GO:0016020;microtubule cytoskeleton#GO:0015630;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;microtubule#GO:0005874;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226 membrane traffic protein#PC00150 HUMAN|HGNC=409|UniProtKB=P47895 P47895 ALDH1A3 PTHR11699:SF209 ALDEHYDE DEHYDROGENASE-RELATED RETINALDEHYDE DEHYDROGENASE 3 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor#GO:0016620;aldehyde dehydrogenase (NAD+) activity#GO:0004029;oxidoreductase activity, acting on the aldehyde or oxo group of donors#GO:0016903;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 regulation of biological quality#GO:0065008;isoprenoid metabolic process#GO:0006720;isoprenoid biosynthetic process#GO:0008299;terpenoid metabolic process#GO:0006721;oxoacid metabolic process#GO:0043436;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;carboxylic acid biosynthetic process#GO:0046394;regulation of hormone levels#GO:0010817;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;diterpenoid metabolic process#GO:0016101;monocarboxylic acid biosynthetic process#GO:0072330;retinoid metabolic process#GO:0001523;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;diterpenoid biosynthetic process#GO:0016102;metabolic process#GO:0008152;aldehyde catabolic process#GO:0046185;biological regulation#GO:0065007;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;terpenoid biosynthetic process#GO:0016114;hormone metabolic process#GO:0042445;aldehyde metabolic process#GO:0006081;cellular process#GO:0009987 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 5-Hydroxytryptamine degredation#P04372>Aldehyde Dehydrogenase#P04402 HUMAN|HGNC=2045|UniProtKB=O15551 O15551 CLDN3 PTHR12002:SF112 CLAUDIN CLAUDIN-3 cellular component biogenesis#GO:0044085;cell junction assembly#GO:0034329;cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component assembly#GO:0022607;cell junction organization#GO:0034330;cell-cell junction organization#GO:0045216;cell-cell junction assembly#GO:0007043;transport#GO:0006810;localization#GO:0051179;paracellular transport#GO:0160184;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234 apical junction complex#GO:0043296;anchoring junction#GO:0070161;cell junction#GO:0030054;tight junction#GO:0070160;cell periphery#GO:0071944;membrane#GO:0016020;cell-cell junction#GO:0005911;plasma membrane#GO:0005886;bicellular tight junction#GO:0005923;cellular anatomical structure#GO:0110165 tight junction#PC00214;cell junction protein#PC00070 HUMAN|HGNC=19909|UniProtKB=Q8N5L8 Q8N5L8 RPP25L PTHR13516:SF8 RIBONUCLEASE P SUBUNIT P25 RIBONUCLEASE P PROTEIN SUBUNIT P25-LIKE PROTEIN RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467 endonuclease complex#GO:1905348;endoribonuclease complex#GO:1902555;ribonucleoprotein complex#GO:1990904;catalytic complex#GO:1902494;sno(s)RNA-containing ribonucleoprotein complex#GO:0005732;intracellular protein-containing complex#GO:0140535;ribonuclease MRP complex#GO:0000172;protein-containing complex#GO:0032991 RNA metabolism protein#PC00031;endoribonuclease#PC00094 HUMAN|HGNC=1691|UniProtKB=P30203 P30203 CD6 PTHR19331:SF477 SCAVENGER RECEPTOR DOMAIN-CONTAINING T-CELL DIFFERENTIATION ANTIGEN CD6 cargo receptor activity#GO:0038024 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 serine protease#PC00203;protease#PC00190 HUMAN|HGNC=14295|UniProtKB=Q9UPX8 Q9UPX8 SHANK2 PTHR24135:SF17 SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN 2 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;signaling receptor binding#GO:0005102;binding#GO:0005488;signaling receptor complex adaptor activity#GO:0030159;protein binding#GO:0005515;signaling adaptor activity#GO:0035591 system process#GO:0003008;cellular component organization or biogenesis#GO:0071840;nervous system process#GO:0050877;synapse organization#GO:0050808;cognition#GO:0050890;cell junction organization#GO:0034330;multicellular organismal process#GO:0032501;cellular process#GO:0009987;cellular component organization#GO:0016043 dendritic tree#GO:0097447;postsynaptic density#GO:0014069;postsynaptic membrane#GO:0045211;dendrite#GO:0030425;dendritic spine#GO:0043197;postsynapse#GO:0098794;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;neuron spine#GO:0044309;asymmetric synapse#GO:0032279;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;synaptic membrane#GO:0097060;cell junction#GO:0030054;neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;plasma membrane region#GO:0098590;postsynaptic specialization#GO:0099572;neuron to neuron synapse#GO:0098984 scaffold/adaptor protein#PC00226 Ionotropic glutamate receptor pathway#P00037>PSD95#P00999 HUMAN|HGNC=7446|UniProtKB=Q9Y4I5 Q9Y4I5 TESMIN PTHR12446:SF22 TESMIN/TSO1-RELATED TESMIN regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=23117|UniProtKB=Q6UWF7 Q6UWF7 NXPE4 PTHR16165:SF27 NXPE FAMILY MEMBER NXPE FAMILY MEMBER 4 HUMAN|HGNC=9857|UniProtKB=P61224 P61224 RAP1B PTHR24070:SF393 RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY RAS-RELATED PROTEIN RAP-1B-RELATED hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817 regulation of cellular process#GO:0050794;negative regulation of transport#GO:0051051;regulation of cell communication#GO:0010646;modulation of chemical synaptic transmission#GO:0050804;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;regulation of secretion#GO:0051046;intracellular signal transduction#GO:0035556;regulation of exocytosis#GO:0017157;response to nitrogen compound#GO:1901698;cellular response to nitrogen compound#GO:1901699;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;regulation of neurotransmitter secretion#GO:0046928;response to stimulus#GO:0050896;regulation of synaptic vesicle exocytosis#GO:2000300;signaling#GO:0023052;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;regulation of secretion by cell#GO:1903530;regulation of neurotransmitter transport#GO:0051588;cellular response to chemical stimulus#GO:0070887;regulation of signaling#GO:0023051;response to oxygen-containing compound#GO:1901700;regulation of trans-synaptic signaling#GO:0099177;response to chemical#GO:0042221;intracellular signaling cassette#GO:0141124;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;regulation of localization#GO:0032879;regulation of transport#GO:0051049 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 small GTPase#PC00208 Gonadotropin-releasing hormone receptor pathway#P06664>Rap1b#G06881;Gonadotropin-releasing hormone receptor pathway#P06664>Rap1b#P06803;Gonadotropin-releasing hormone receptor pathway#P06664>Rap1b#G06668;Integrin signalling pathway#P00034>Rap1#P00906;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Rap1#P00703;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Rap1#P00734 HUMAN|HGNC=3772|UniProtKB=P31512 P31512 FMO4 PTHR23023:SF74 DIMETHYLANILINE MONOOXYGENASE DIMETHYLANILINE MONOOXYGENASE [N-OXIDE-FORMING] 4 oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen#GO:0016709;catalytic activity#GO:0003824;monooxygenase activity#GO:0004497 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;response to chemical#GO:0042221;xenobiotic metabolic process#GO:0006805;cellular response to xenobiotic stimulus#GO:0071466;response to xenobiotic stimulus#GO:0009410;cellular response to chemical stimulus#GO:0070887;metabolic process#GO:0008152 oxidoreductase#PC00176;oxygenase#PC00177 HUMAN|HGNC=2367|UniProtKB=P02741 P02741 CRP PTHR45869:SF21 C-REACTIVE PROTEIN-RELATED C-REACTIVE PROTEIN protein-lipid complex binding#GO:0071814;low-density lipoprotein particle binding#GO:0030169;complement binding#GO:0001848;binding#GO:0005488;lipoprotein particle binding#GO:0071813;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 defense response to symbiont#GO:0140546;immune response#GO:0006955;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to other organism#GO:0051707;response to stimulus#GO:0050896;defense response to other organism#GO:0098542;inflammatory response#GO:0006954;immune system process#GO:0002376;response to external stimulus#GO:0009605;acute inflammatory response#GO:0002526;defense response#GO:0006952;innate immune response#GO:0045087 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=11894|UniProtKB=Q13829 Q13829 TNFAIP1 PTHR11145:SF17 BTB/POZ DOMAIN-CONTAINING ADAPTER FOR CUL3-MEDIATED RHOA DEGRADATION PROTEIN FAMILY MEMBER BTB_POZ DOMAIN-CONTAINING ADAPTER FOR CUL3-MEDIATED RHOA DEGRADATION PROTEIN 2 regulation of Rho protein signal transduction#GO:0035023;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;protein modification by small protein conjugation#GO:0032446;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;regulation of intracellular signal transduction#GO:1902531;protein modification by small protein conjugation or removal#GO:0070647;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;proteasomal protein catabolic process#GO:0010498;negative regulation of signal transduction#GO:0009968;protein ubiquitination#GO:0016567;cellular process#GO:0009987;regulation of small GTPase mediated signal transduction#GO:0051056;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of cell communication#GO:0010646;primary metabolic process#GO:0044238;protein modification process#GO:0036211;modification-dependent protein catabolic process#GO:0019941;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;negative regulation of response to stimulus#GO:0048585;post-translational protein modification#GO:0043687;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;negative regulation of cellular process#GO:0048523;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;regulation of response to stimulus#GO:0048583 catalytic complex#GO:1902494;transferase complex#GO:1990234;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535;Cul3-RING ubiquitin ligase complex#GO:0031463;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151 scaffold/adaptor protein#PC00226 HUMAN|HGNC=28701|UniProtKB=Q6ZMJ2 Q6ZMJ2 SCARA5 PTHR19331:SF482 SCAVENGER RECEPTOR DOMAIN-CONTAINING SCAVENGER RECEPTOR CLASS A MEMBER 5 cargo receptor activity#GO:0038024 intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion homeostasis#GO:0050801;endocytosis#GO:0006897;intracellular iron ion homeostasis#GO:0006879;homeostatic process#GO:0042592;inorganic ion homeostasis#GO:0098771;chemical homeostasis#GO:0048878;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;localization#GO:0051179;establishment of localization#GO:0051234;import into cell#GO:0098657;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 serine protease#PC00203;protease#PC00190 HUMAN|HGNC=33939|UniProtKB=A0PK11 A0PK11 CLRN2 PTHR31548:SF5 CLARIN CLARIN-2 HUMAN|HGNC=5039|UniProtKB=P52597 P52597 HNRNPF PTHR13976:SF32 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN F nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA splicing#GO:0043484;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;nucleoplasm#GO:0005654;organelle#GO:0043226;protein-containing complex#GO:0032991;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 RNA processing factor#PC00147;RNA metabolism protein#PC00031;RNA splicing factor#PC00148 HUMAN|HGNC=20247|UniProtKB=Q7L2J0 Q7L2J0 MEPCE PTHR12315:SF0 BICOID-INTERACTING PROTEIN RELATED 7SK SNRNA METHYLPHOSPHATE CAPPING ENZYME snRNA binding#GO:0017069;RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;O-methyltransferase activity#GO:0008171;methyltransferase activity#GO:0008168;RNA methyltransferase activity#GO:0008173;catalytic activity, acting on RNA#GO:0140098;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a nucleic acid#GO:0140640 macromolecule metabolic process#GO:0043170;snRNA processing#GO:0016180;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;gene expression#GO:0010467;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;snRNA metabolic process#GO:0016073;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 HUMAN|HGNC=2063|UniProtKB=O15247 O15247 CLIC2 PTHR43920:SF4 CHLORIDE INTRACELLULAR CHANNEL, ISOFORM A CHLORIDE INTRACELLULAR CHANNEL PROTEIN 2 channel activity#GO:0015267;monoatomic anion channel activity#GO:0005253;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic anion transmembrane transporter activity#GO:0008509;chloride transmembrane transporter activity#GO:0015108;passive transmembrane transporter activity#GO:0022803;chloride channel activity#GO:0005254;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 chloride transport#GO:0006821;monoatomic anion transport#GO:0006820;transport#GO:0006810;establishment of localization#GO:0051234;localization#GO:0051179;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698 membrane#GO:0016020;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=31906|UniProtKB=P0CL80 P0CL80 GAGE12F PTHR14047:SF30 P ANTIGEN FAMILY MEMBER 5-RELATED G ANTIGEN 1-RELATED HUMAN|HGNC=252|UniProtKB=P08319 P08319 ADH4 PTHR43880:SF14 ALCOHOL DEHYDROGENASE ALL-TRANS-RETINOL DEHYDROGENASE [NAD(+)] ADH4 catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;zinc ion binding#GO:0008270;alcohol dehydrogenase (NAD+) activity#GO:0004022;oxidoreductase activity#GO:0016491;binding#GO:0005488;small molecule binding#GO:0036094;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;ion binding#GO:0043167;transition metal ion binding#GO:0046914;metal ion binding#GO:0046872;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;cation binding#GO:0043169 detoxification#GO:0098754;cellular response to toxic substance#GO:0097237;aldehyde catabolic process#GO:0046185;response to chemical#GO:0042221;cellular response to oxygen-containing compound#GO:1901701;aldehyde metabolic process#GO:0006081;cellular process#GO:0009987;metabolic process#GO:0008152;small molecule catabolic process#GO:0044282;response to stimulus#GO:0050896;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;response to toxic substance#GO:0009636;cellular response to stimulus#GO:0051716;cellular detoxification of aldehyde#GO:0110095;response to oxygen-containing compound#GO:1901700;cellular detoxification#GO:1990748;cellular response to chemical stimulus#GO:0070887 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 dehydrogenase#PC00092 HUMAN|HGNC=25255|UniProtKB=A6NM62 A6NM62 LRRC53 PTHR24369:SF161 ANTIGEN BSP, PUTATIVE-RELATED LEUCINE-RICH REPEAT-CONTAINING PROTEIN 53 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cell adhesion molecule#PC00069 HUMAN|HGNC=11878|UniProtKB=Q9NRS4 Q9NRS4 TMPRSS4 PTHR24253:SF31 TRANSMEMBRANE PROTEASE SERINE TRANSMEMBRANE PROTEASE SERINE 4 serine-type peptidase activity#GO:0008236;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;serine hydrolase activity#GO:0017171;peptidase activity#GO:0008233 biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604;protein processing#GO:0016485;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;proteolysis#GO:0006508;metabolic process#GO:0008152 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;vesicle#GO:0031982;intracellular vesicle#GO:0097708;secretory vesicle#GO:0099503;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 protein modifying enzyme#PC00260;serine protease#PC00203;protease#PC00190 HUMAN|HGNC=16823|UniProtKB=P17152 P17152 TMEM11 PTHR15099:SF2 PROTEIN PM1 TRANSMEMBRANE PROTEIN 11, MITOCHONDRIAL cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;inner mitochondrial membrane organization#GO:0007007;mitochondrial membrane organization#GO:0007006;mitochondrion organization#GO:0007005;membrane organization#GO:0061024;cellular component organization or biogenesis#GO:0071840 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;organelle envelope#GO:0031967;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HUMAN|HGNC=9853|UniProtKB=O15397 O15397 IPO8 PTHR10997:SF26 IMPORTIN-7, 8, 11 IMPORTIN-8 molecular carrier activity#GO:0140104;nucleocytoplasmic carrier activity#GO:0140142 establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;import into nucleus#GO:0051170;macromolecule localization#GO:0033036;protein localization to nucleus#GO:0034504;intracellular protein localization#GO:0008104;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;protein localization to organelle#GO:0033365;nuclear transport#GO:0051169;protein import into nucleus#GO:0006606;protein transport#GO:0015031;localization#GO:0051179;cellular localization#GO:0051641;nucleocytoplasmic transport#GO:0006913 cytosol#GO:0005829;organelle envelope#GO:0031967;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 transporter#PC00227 HUMAN|HGNC=20067|UniProtKB=Q8NB14 Q8NB14 USP38 PTHR24006:SF710 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 38 catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;cysteine-type deubiquitinase activity#GO:0004843;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005 regulation of protein stability#GO:0031647;biological regulation#GO:0065007;regulation of biological quality#GO:0065008 nucleus#GO:0005634;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 protease#PC00190;cysteine protease#PC00081 HUMAN|HGNC=7800|UniProtKB=Q9UBC1 Q9UBC1 NFKBIL1 PTHR15263:SF2 I-KAPPA-B-LIKE PROTEIN IKBL NF-KAPPA-B INHIBITOR-LIKE PROTEIN 1 molecular function regulator activity#GO:0098772;molecular function inhibitor activity#GO:0140678 negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;regulation of immune response#GO:0050776;regulation of signaling#GO:0023051;regulation of defense response#GO:0031347;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of canonical NF-kappaB signal transduction#GO:0043124;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of response to biotic stimulus#GO:0002831;regulation of response to stress#GO:0080134;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of innate immune response#GO:0045088;regulation of canonical NF-kappaB signal transduction#GO:0043122;negative regulation of response to stimulus#GO:0048585;regulation of response to external stimulus#GO:0032101;regulation of signal transduction#GO:0009966;negative regulation of immune system process#GO:0002683;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 protein-binding activity modulator#PC00095 B cell activation#P00010>I kappa B#P00392 HUMAN|HGNC=16902|UniProtKB=O14874 O14874 BCKDK PTHR11947:SF20 PYRUVATE DEHYDROGENASE KINASE BRANCHED-CHAIN ALPHA-KETOACID DEHYDROGENASE KINASE catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674 regulation of lipid metabolic process#GO:0019216;regulation of carbohydrate metabolic process#GO:0006109;regulation of biosynthetic process#GO:0009889;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=27603|UniProtKB=O75290 O75290 ZNF780A PTHR24377:SF287 IP01015P-RELATED ZINC FINGER PROTEIN 780A sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676 regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=28720|UniProtKB=Q9H6J7 Q9H6J7 CSTPP1 PTHR34252:SF1 UPF0705 PROTEIN C11ORF49 CENTRIOLAR SATELLITE-ASSOCIATED TUBULIN POLYGLUTAMYLASE COMPLEX REGULATOR 1 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226;cytoskeleton organization#GO:0007010;microtubule-based process#GO:0007017 HUMAN|HGNC=23592|UniProtKB=Q6T311 Q6T311 ARL9 PTHR46724:SF2 ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 9-RELATED ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 9 HUMAN|HGNC=6380|UniProtKB=Q96E93 Q96E93 KLRG1 PTHR47648:SF1 KILLER CELL LECTIN-LIKE RECEPTOR SUBFAMILY G MEMBER 1 KILLER CELL LECTIN-LIKE RECEPTOR SUBFAMILY G MEMBER 1 transmembrane signal receptor#PC00197 HUMAN|HGNC=26249|UniProtKB=Q56UN5 Q56UN5 MAP3K19 PTHR48011:SF4 CCR4-NOT TRANSCRIPTIONAL COMPLEX SUBUNIT CAF120-RELATED MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19 protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824 cell communication#GO:0007154;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052 HUMAN|HGNC=17371|UniProtKB=Q5TD97 Q5TD97 FHL5 PTHR24205:SF7 FOUR AND A HALF LIM DOMAINS PROTEIN FOUR AND A HALF LIM DOMAINS PROTEIN 5 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription coactivator activity#GO:0003713 regulation of DNA-templated transcription#GO:0006355;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518 transcription cofactor#PC00217 HUMAN|HGNC=11070|UniProtKB=P57103 P57103 SLC8A3 PTHR11878:SF7 SODIUM/CALCIUM EXCHANGER SODIUM_CALCIUM EXCHANGER 3 monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;monoatomic ion transmembrane transporter activity#GO:0015075;sodium ion transmembrane transporter activity#GO:0015081;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873;antiporter activity#GO:0015297;secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;monoatomic ion homeostasis#GO:0050801;calcium ion transport#GO:0006816;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;establishment of localization#GO:0051234;intracellular monoatomic cation homeostasis#GO:0030003;chemical homeostasis#GO:0048878;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;metal ion transport#GO:0030001;export from cell#GO:0140352;homeostatic process#GO:0042592;sodium ion transport#GO:0006814;intracellular monoatomic ion homeostasis#GO:0006873;calcium ion transmembrane transport#GO:0070588;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074 cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;cell projection#GO:0042995;membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005;sarcolemma#GO:0042383;axon#GO:0030424 secondary carrier transporter#PC00258 HUMAN|HGNC=23698|UniProtKB=Q8IVF7 Q8IVF7 FMNL3 PTHR45857:SF3 FORMIN-LIKE PROTEIN FORMIN-LIKE PROTEIN 3 binding#GO:0005488;actin binding#GO:0003779;actin filament binding#GO:0051015;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877 cell motility#GO:0048870;cell migration#GO:0016477;cellular process#GO:0009987 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=23244|UniProtKB=P49756 P49756 RBM25 PTHR18806:SF4 RBM25 PROTEIN RNA-BINDING PROTEIN 25 mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of biological process#GO:0050789;regulation of alternative mRNA splicing, via spliceosome#GO:0000381;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of mRNA processing#GO:0050684;biological regulation#GO:0065007;regulation of RNA splicing#GO:0043484;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biosynthetic process#GO:0009889;regulation of mRNA metabolic process#GO:1903311;regulation of gene expression#GO:0010468 HUMAN|HGNC=18899|UniProtKB=Q9BYR2 Q9BYR2 KRTAP4-5 PTHR23262:SF71 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 4-5 structural protein#PC00211 HUMAN|HGNC=3365|UniProtKB=O75355 O75355 ENTPD3 PTHR11782:SF38 ADENOSINE/GUANOSINE DIPHOSPHATASE ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 3 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;nucleoside diphosphate phosphatase activity#GO:0017110;ribonucleoside triphosphate phosphatase activity#GO:0017111 organophosphate catabolic process#GO:0046434;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;nucleoside diphosphate metabolic process#GO:0009132;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;nucleoside phosphate catabolic process#GO:1901292;nucleobase-containing compound metabolic process#GO:0006139;nucleoside phosphate metabolic process#GO:0006753;organophosphate metabolic process#GO:0019637;nucleobase-containing compound catabolic process#GO:0034655;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;cellular process#GO:0009987;nucleoside diphosphate catabolic process#GO:0009134 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 hydrolase#PC00121;nucleotide phosphatase#PC00173;phosphatase#PC00181 HUMAN|HGNC=8968|UniProtKB=P01833 P01833 PIGR PTHR11860:SF82 POLYMERIC-IMMUNOGLOBULIN RECEPTOR POLYMERIC IMMUNOGLOBULIN RECEPTOR molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=8799|UniProtKB=P04085 P04085 PDGFA PTHR11633:SF3 PLATELET-DERIVED GROWTH FACTOR PLATELET-DERIVED GROWTH FACTOR SUBUNIT A protein binding#GO:0005515;growth factor receptor binding#GO:0070851;signaling receptor binding#GO:0005102;binding#GO:0005488 regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;tube development#GO:0035295;regulation of locomotion#GO:0040012;positive regulation of response to stimulus#GO:0048584;multicellular organismal process#GO:0032501;positive regulation of cellular process#GO:0048522;positive regulation of cell migration#GO:0030335;positive regulation of locomotion#GO:0040017;positive regulation of MAPK cascade#GO:0043410;developmental process#GO:0032502;positive regulation of intracellular signal transduction#GO:1902533;regulation of cell migration#GO:0030334;regulation of response to stimulus#GO:0048583;positive regulation of ERK1 and ERK2 cascade#GO:0070374;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;tube morphogenesis#GO:0035239;blood vessel development#GO:0001568;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051896;system development#GO:0048731;regulation of cell motility#GO:2000145;regulation of cell population proliferation#GO:0042127;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of ERK1 and ERK2 cascade#GO:0070372;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;anatomical structure formation involved in morphogenesis#GO:0048646;vasculature development#GO:0001944;multicellular organism development#GO:0007275;regulation of MAPK cascade#GO:0043408;cell surface receptor signaling pathway#GO:0007166;signaling#GO:0023052;response to stimulus#GO:0050896;positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051897;circulatory system development#GO:0072359;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;positive regulation of cell motility#GO:2000147;positive regulation of cell population proliferation#GO:0008284;blood vessel morphogenesis#GO:0048514;angiogenesis#GO:0001525;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;animal gross anatomical part developmental process#GO:0160108 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 growth factor#PC00112 PDGF signaling pathway#P00047>PDGF#P01170;Angiogenesis#P00005>PDGF#P00224 HUMAN|HGNC=18826|UniProtKB=Q9BQG2 Q9BQG2 NUDT12 PTHR42904:SF6 NUDIX HYDROLASE, NUDC SUBFAMILY NAD-CAPPED RNA HYDROLASE NUDT12 hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817 organophosphate catabolic process#GO:0046434;nucleotide metabolic process#GO:0009117;pyridine-containing compound metabolic process#GO:0072524;purine nucleotide catabolic process#GO:0006195;pyridine nucleotide catabolic process#GO:0019364;nucleoside phosphate metabolic process#GO:0006753;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;nucleoside phosphate catabolic process#GO:1901292;purine nucleotide metabolic process#GO:0006163;pyridine-containing compound catabolic process#GO:0072526;purine-containing compound metabolic process#GO:0072521;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;nucleobase-containing small molecule metabolic process#GO:0055086;purine-containing compound catabolic process#GO:0072523;metabolic process#GO:0008152;nucleotide catabolic process#GO:0009166;nucleobase-containing compound metabolic process#GO:0006139;nicotinamide nucleotide metabolic process#GO:0046496;cellular process#GO:0009987;NAD+ metabolic process#GO:0019674;organophosphate metabolic process#GO:0019637;nucleobase-containing compound catabolic process#GO:0034655;NADP+ metabolic process#GO:0006739 hydrolase#PC00121 HUMAN|HGNC=17|UniProtKB=P22760 P22760 AADAC PTHR23024:SF222 ARYLACETAMIDE DEACETYLASE ARYLACETAMIDE DEACETYLASE hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;lipase activity#GO:0016298;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;carboxylic ester hydrolase activity#GO:0052689 neutral lipid metabolic process#GO:0006638;acylglycerol catabolic process#GO:0046464;acylglycerol metabolic process#GO:0006639;glycerolipid catabolic process#GO:0046503;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;neutral lipid catabolic process#GO:0046461;catabolic process#GO:0009056;glycerolipid metabolic process#GO:0046486;primary metabolic process#GO:0044238;cellular process#GO:0009987;lipid catabolic process#GO:0016042 endoplasmic reticulum membrane#GO:0005789;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 deacetylase#PC00087 HUMAN|HGNC=3482|UniProtKB=P38117 P38117 ETFB PTHR21294:SF8 ELECTRON TRANSFER FLAVOPROTEIN BETA-SUBUNIT ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT BETA lipid modification#GO:0030258;fatty acid oxidation#GO:0019395;lipid metabolic process#GO:0006629;fatty acid beta-oxidation#GO:0006635;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;monocarboxylic acid catabolic process#GO:0072329;lipid catabolic process#GO:0016042;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;fatty acid catabolic process#GO:0009062;lipid oxidation#GO:0034440;oxoacid metabolic process#GO:0043436;small molecule catabolic process#GO:0044282;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HUMAN|HGNC=33345|UniProtKB=A0A1W2PPF3 A0A1W2PPF3 DUXB PTHR46123:SF5 MIX-TYPE HOMEOBOX GENE 1-RELATED DOUBLE HOMEOBOX PROTEIN B sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=199|UniProtKB=O43506 O43506 ADAM20 PTHR11905:SF232 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 20 metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096 cellular process#GO:0009987;proteolysis#GO:0006508;metabolic process#GO:0008152;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 metalloprotease#PC00153;protease#PC00190 HUMAN|HGNC=25510|UniProtKB=Q9GZU3 Q9GZU3 TMEM39B PTHR12995:SF2 FI21814P1 TRANSMEMBRANE PROTEIN 39B cellular anatomical structure#GO:0110165;membrane#GO:0016020 HUMAN|HGNC=25057|UniProtKB=Q96GI7 Q96GI7 FAM89A PTHR46949:SF3 LEUCINE REPEAT ADAPTER PROTEIN 25 PROTEIN FAM89A scaffold/adaptor protein#PC00226 HUMAN|HGNC=14446|UniProtKB=Q8TEW8 Q8TEW8 PARD3B PTHR16484:SF4 PARTITIONING DEFECTIVE 3 RELATED PARTITIONING DEFECTIVE 3 HOMOLOG B ion binding#GO:0043167;anion binding#GO:0043168;phosphatidylinositol binding#GO:0035091;binding#GO:0005488;small molecule binding#GO:0036094 cytoskeleton organization#GO:0007010;macromolecule localization#GO:0033036;organelle organization#GO:0006996;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;intracellular protein localization#GO:0008104;microtubule-based process#GO:0007017;cellular component organization#GO:0016043;establishment of cell polarity#GO:0030010;localization#GO:0051179;establishment or maintenance of epithelial cell apical/basal polarity#GO:0045197;microtubule cytoskeleton organization#GO:0000226;establishment or maintenance of cell polarity#GO:0007163;establishment or maintenance of apical/basal cell polarity#GO:0035088;cell adhesion#GO:0007155;establishment or maintenance of bipolar cell polarity#GO:0061245 apical plasma membrane#GO:0016324;cell-cell junction#GO:0005911;membrane#GO:0016020;cell cortex#GO:0005938;cell periphery#GO:0071944;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cytoplasm#GO:0005737;apical junction complex#GO:0043296;apical part of cell#GO:0045177;cell junction#GO:0030054;adherens junction#GO:0005912;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161 HUMAN|HGNC=3349|UniProtKB=P17813 P17813 ENG PTHR14002:SF1 ENDOGLIN/TGF-BETA RECEPTOR TYPE III ENDOGLIN growth factor binding#GO:0019838;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein serine/threonine kinase activity#GO:0004675;protein binding#GO:0005515;protein kinase activity#GO:0004672;binding#GO:0005488;cytokine receptor binding#GO:0005126;protein serine/threonine kinase activity#GO:0004674;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;transferase activity#GO:0016740;carbohydrate derivative binding#GO:0097367;kinase activity#GO:0016301;transforming growth factor beta receptor activity#GO:0005024;molecular transducer activity#GO:0060089;signaling receptor binding#GO:0005102;glycosaminoglycan binding#GO:0005539;catalytic activity, acting on a protein#GO:0140096;cytokine binding#GO:0019955;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transforming growth factor beta binding#GO:0050431;transferase activity, transferring phosphorus-containing groups#GO:0016772 transforming growth factor beta receptor signaling pathway#GO:0007179;signal transduction#GO:0007165;cellular process#GO:0009987;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;vasculogenesis#GO:0001570;cell surface receptor signaling pathway#GO:0007166;mesenchymal cell differentiation#GO:0048762;multicellular organism development#GO:0007275;animal organ development#GO:0048513;vasculature development#GO:0001944;response to endogenous stimulus#GO:0009719;blood vessel morphogenesis#GO:0048514;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;circulatory system development#GO:0072359;cell differentiation#GO:0030154;signaling#GO:0023052;animal gross anatomical part developmental process#GO:0160108;regulation of signaling#GO:0023051;cellular response to growth factor stimulus#GO:0071363;tissue development#GO:0009888;multicellular organismal process#GO:0032501;regulation of cellular response to growth factor stimulus#GO:0090287;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;tube development#GO:0035295;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;developmental process#GO:0032502;regulation of response to stimulus#GO:0048583;cellular developmental process#GO:0048869;mesenchyme development#GO:0060485;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092;regulation of transforming growth factor beta receptor signaling pathway#GO:0017015;blood vessel development#GO:0001568;cellular response to stimulus#GO:0051716;cellular response to transforming growth factor beta stimulus#GO:0071560;tube morphogenesis#GO:0035239;response to growth factor#GO:0070848;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;response to transforming growth factor beta#GO:0071559;cell communication#GO:0007154;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;system development#GO:0048731 transmembrane signal receptor#PC00197 HUMAN|HGNC=11038|UniProtKB=P53794 P53794 SLC5A3 PTHR11819:SF150 SOLUTE CARRIER FAMILY 5 SMALL RIBOSOMAL SUBUNIT PROTEIN BS6M-RELATED solute:sodium symporter activity#GO:0015370;monoatomic cation transmembrane transporter activity#GO:0008324;symporter activity#GO:0015293;solute:monoatomic cation symporter activity#GO:0015294;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 secondary carrier transporter#PC00258;transporter#PC00227 HUMAN|HGNC=4976|UniProtKB=P50747 P50747 HLCS PTHR12835:SF5 BIOTIN PROTEIN LIGASE BIOTIN--PROTEIN LIGASE ligase activity, forming carbon-nitrogen bonds#GO:0016879;catalytic activity, acting on a protein#GO:0140096;ligase activity#GO:0016874;catalytic activity#GO:0003824 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 ligase#PC00142 HUMAN|HGNC=1349|UniProtKB=Q8IVG5 Q8IVG5 SAMD9L PTHR16155:SF18 DED DOMAIN-CONTAINING PROTEIN STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 9-LIKE cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=28122|UniProtKB=Q9BRG1 Q9BRG1 VPS25 PTHR13149:SF0 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS25 VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 25 protein localization to vacuole#GO:0072665;protein metabolic process#GO:0019538;localization#GO:0051179;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;protein localization to organelle#GO:0033365;catabolic process#GO:0009056;transport#GO:0006810;vacuolar transport#GO:0007034;intracellular transport#GO:0046907;ubiquitin-dependent protein catabolic process#GO:0006511;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;establishment of protein localization to organelle#GO:0072594;late endosome to vacuole transport via multivesicular body sorting pathway#GO:0032511;multivesicular body sorting pathway#GO:0071985;macromolecule localization#GO:0033036;ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043162;endosome transport via multivesicular body sorting pathway#GO:0032509;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein transport#GO:0015031;cellular localization#GO:0051641;protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043328;late endosome to vacuole transport#GO:0045324;establishment of protein localization to vacuole#GO:0072666;intracellular protein transport#GO:0006886;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;endosomal transport#GO:0016197;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;vesicle-mediated transport#GO:0016192 membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endosome membrane#GO:0010008;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;vesicle membrane#GO:0012506;membrane#GO:0016020 membrane traffic protein#PC00150 HUMAN|HGNC=23252|UniProtKB=Q58HT5 Q58HT5 AWAT1 PTHR12317:SF16 DIACYLGLYCEROL O-ACYLTRANSFERASE ACYL-COA WAX ALCOHOL ACYLTRANSFERASE 1 acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746 lipid metabolic process#GO:0006629;triglyceride metabolic process#GO:0006641;acylglycerol metabolic process#GO:0006639;metabolic process#GO:0008152;neutral lipid metabolic process#GO:0006638;glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;glycerolipid metabolic process#GO:0046486;triglyceride biosynthetic process#GO:0019432 membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622 transferase#PC00220;acyltransferase#PC00042 HUMAN|HGNC=4646|UniProtKB=P52655 P52655 GTF2A1 PTHR12694:SF7 TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1 TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1 transcription coregulator activity#GO:0003712;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;double-stranded DNA binding#GO:0003690;core promoter sequence-specific DNA binding#GO:0001046;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677 transcription initiation at RNA polymerase II promoter#GO:0006367;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;transcription by RNA polymerase II#GO:0006366;macromolecule metabolic process#GO:0043170;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;DNA-templated transcription initiation#GO:0006352;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070 RNA polymerase II, holoenzyme#GO:0016591;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;membrane-bounded organelle#GO:0043227;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;transcription regulator complex#GO:0005667;transferase complex#GO:1990234;protein-containing complex#GO:0032991;transcription factor TFIID complex#GO:0005669;RNA polymerase II transcription regulator complex#GO:0090575;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;RNA polymerase complex#GO:0030880 general transcription factor#PC00259 General transcription regulation#P00023>TFIIA complex#P00662;Transcription regulation by bZIP transcription factor#P00055>TFIIA complex#P01390 HUMAN|HGNC=9227|UniProtKB=Q9NQ55 Q9NQ55 PPAN PTHR12661:SF5 PETER PAN-RELATED SUPPRESSOR OF SWI4 1 HOMOLOG nucleic acid binding#GO:0003676;rRNA binding#GO:0019843;binding#GO:0005488;RNA binding#GO:0003723 RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;ribosome biogenesis#GO:0042254;ribosomal large subunit biogenesis#GO:0042273;nucleic acid biosynthetic process#GO:0141187;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;gene expression#GO:0010467;maturation of LSU-rRNA#GO:0000470;biosynthetic process#GO:0009058;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 protein-containing complex#GO:0032991;preribosome, large subunit precursor#GO:0030687;preribosome#GO:0030684;ribonucleoprotein complex#GO:1990904 RNA metabolism protein#PC00031 HUMAN|HGNC=11403|UniProtKB=Q9Y6E0 Q9Y6E0 STK24 PTHR48012:SF22 STERILE20-LIKE KINASE, ISOFORM B-RELATED SERINE_THREONINE-PROTEIN KINASE 24 transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 negative regulation of locomotion#GO:0040013;negative regulation of cell motility#GO:2000146;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;signal transduction#GO:0007165;cellular process#GO:0009987;negative regulation of cell migration#GO:0030336;negative regulation of cellular process#GO:0048523;regulation of cell migration#GO:0030334;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;regulation of cell motility#GO:2000145;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=4880|UniProtKB=Q9Y5J3 Q9Y5J3 HEY1 PTHR10985:SF78 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED HAIRY_ENHANCER-OF-SPLIT RELATED WITH YRPW MOTIF PROTEIN 1 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of neurogenesis#GO:0050767;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of developmental process#GO:0050793;pattern specification process#GO:0007389;regulation of nervous system development#GO:0051960;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;cell communication#GO:0007154;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of cell development#GO:0060284;negative regulation of macromolecule metabolic process#GO:0010605;regulation of neuron differentiation#GO:0045664;multicellular organismal process#GO:0032501;regionalization#GO:0003002;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;regulation of cell differentiation#GO:0045595;developmental process#GO:0032502;Notch signaling pathway#GO:0007219;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of biological process#GO:0048519;regulation of multicellular organismal development#GO:2000026;regulation of biological process#GO:0050789;circulatory system development#GO:0072359;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;signaling#GO:0023052;negative regulation of metabolic process#GO:0009892;animal gross anatomical part developmental process#GO:0160108;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of multicellular organismal process#GO:0051239;anterior/posterior pattern specification#GO:0009952;negative regulation of RNA metabolic process#GO:0051253;cell surface receptor signaling pathway#GO:0007166;negative regulation of RNA biosynthetic process#GO:1902679;multicellular organism development#GO:0007275 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 basic helix-loop-helix transcription factor#PC00055 Notch signaling pathway#P00045>E(spl)-C genes#G01541 HUMAN|HGNC=25571|UniProtKB=Q9NVG8 Q9NVG8 TBC1D13 PTHR22957:SF27 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN TBC1 DOMAIN FAMILY MEMBER 13 enzyme activator activity#GO:0008047;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;protein transport#GO:0015031;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;transport#GO:0006810;intracellular protein transport#GO:0006886;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 GTPase-activating protein#PC00257;protein-binding activity modulator#PC00095;G-protein modulator#PC00022 HUMAN|HGNC=11856|UniProtKB=P48230 P48230 TM4SF4 PTHR14198:SF15 TRANSMEMBRANE 4 L6 FAMILY MEMBER 1-RELATED TRANSMEMBRANE 4 L6 FAMILY MEMBER 4 cellular anatomical structure#GO:0110165;membrane#GO:0016020 HUMAN|HGNC=27260|UniProtKB=Q147U1 Q147U1 ZNF846 PTHR24381:SF345 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 846 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=8525|UniProtKB=O14753 O14753 OVOL1 PTHR10032:SF217 ZINC FINGER PROTEIN WITH KRAB AND SCAN DOMAINS TRANSCRIPTION FACTOR OVO-LIKE 1-RELATED DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 animal gross anatomical part developmental process#GO:0160108;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;developmental process#GO:0032502;epidermis development#GO:0008544;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;epidermal cell differentiation#GO:0009913;epithelial cell differentiation#GO:0030855;tissue development#GO:0009888;epithelium development#GO:0060429;regulation of nucleobase-containing compound metabolic process#GO:0019219 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=20694|UniProtKB=Q99865 Q99865 SPIN2A PTHR10405:SF13 SPINDLIN SPINDLIN-2A-RELATED protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;histone H3 reader activity#GO:0140006;histone reader activity#GO:0140566;chromatin-protein adaptor activity#GO:0140463 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|Ensembl=ENSG00000233974.4|UniProtKB=A0ABB0MVE2 A0ABB0MVE2 PTHR15566:SF4 POM121-LIKE POM121-LIKE PROTEIN 1-RELATED HUMAN|HGNC=21357|UniProtKB=Q5T0W9 Q5T0W9 FAM83B PTHR16181:SF31 PROTEIN FAM83A-RELATED PROTEIN FAM83B kinase binding#GO:0019900;binding#GO:0005488;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;protein binding#GO:0005515 cell communication#GO:0007154;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789 membrane#GO:0016020;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=6298|UniProtKB=P56696 P56696 KCNQ4 PTHR47735:SF7 POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4 POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4 transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261;potassium channel activity#GO:0005267;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;transporter activity#GO:0005215;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832 cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;potassium ion transmembrane transport#GO:0071805;potassium ion transport#GO:0006813;transport#GO:0006810;monoatomic ion transport#GO:0006811;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812 transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane#GO:0005886;membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797 transporter#PC00227;voltage-gated ion channel#PC00241 HUMAN|HGNC=49179|UniProtKB=A6NGN4 A6NGN4 PRAMEF25 PTHR14224:SF112 SIMILAR TO PREFERENTIALLY EXPRESSED ANTIGEN IN MELANOMA-LIKE 3 PRAME FAMILY MEMBER 11-RELATED enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cytoplasm#GO:0005737;cullin-RING ubiquitin ligase complex#GO:0031461;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;ubiquitin ligase complex#GO:0000151;Cul2-RING ubiquitin ligase complex#GO:0031462;catalytic complex#GO:1902494;transferase complex#GO:1990234 HUMAN|HGNC=25474|UniProtKB=Q8TC92 Q8TC92 ENOX1 PTHR16001:SF6 ANGEL WING family ECTO-NOX DISULFIDE-THIOL EXCHANGER 1 oxidoreductase#PC00176 HUMAN|HGNC=24745|UniProtKB=Q8NA69 Q8NA69 SAXO5 PTHR34828:SF1 TESTIS-EXPRESSED PROTEIN 45 STABILIZER OF AXONEMAL MICROTUBULES 5 HUMAN|HGNC=698|UniProtKB=P56559 P56559 ARL4C PTHR11711:SF119 ADP RIBOSYLATION FACTOR-RELATED ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 4C guanyl nucleotide binding#GO:0019001;binding#GO:0005488;anion binding#GO:0043168;small molecule binding#GO:0036094;nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;ribonucleotide binding#GO:0032553;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555 protein transport#GO:0015031;localization#GO:0051179;cellular localization#GO:0051641;localization within membrane#GO:0051668;endocytic recycling#GO:0032456;intracellular protein localization#GO:0008104;vesicle-mediated transport to the plasma membrane#GO:0098876;endosomal transport#GO:0016197;establishment of localization#GO:0051234;intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907;vesicle-mediated transport#GO:0016192;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule localization#GO:0033036 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 G-protein#PC00020 Huntington disease#P00029>ARF#P00786 HUMAN|HGNC=21351|UniProtKB=Q5SZD1 Q5SZD1 C6orf141 PTHR36880:SF1 9130008F23RIK PROTEIN 9130008F23RIK PROTEIN HUMAN|HGNC=29324|UniProtKB=Q8TEH3 Q8TEH3 DENND1A PTHR13196:SF22 DENN DOMAIN-CONTAINING DENN DOMAIN-CONTAINING PROTEIN 1A binding#GO:0005488;phospholipid binding#GO:0005543;lipid binding#GO:0008289;phosphatidylinositol phosphate binding#GO:1901981 intracellular transport#GO:0046907;localization within membrane#GO:0051668;transport#GO:0006810;localization#GO:0051179;import into cell#GO:0098657;establishment of localization#GO:0051234;cellular localization#GO:0051641;endosomal transport#GO:0016197;vesicle-mediated transport to the plasma membrane#GO:0098876;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;endocytic recycling#GO:0032456;endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192 clathrin-coated vesicle#GO:0030136;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;coated vesicle#GO:0030135;intracellular anatomical structure#GO:0005622;intracellular vesicle#GO:0097708;cytosol#GO:0005829;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=4511|UniProtKB=Q9Y2T6 Q9Y2T6 GPR55 PTHR24232:SF56 G-PROTEIN COUPLED RECEPTOR G PROTEIN-COUPLED RECEPTOR 55 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=188|UniProtKB=O14672 O14672 ADAM10 PTHR45702:SF4 ADAM10/ADAM17 METALLOPEPTIDASE FAMILY MEMBER DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 10 peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;Notch signaling pathway#GO:0007219;cell surface receptor signaling pathway#GO:0007166;metabolic process#GO:0008152;biological regulation#GO:0065007;membrane protein ectodomain proteolysis#GO:0006509;signal transduction#GO:0007165;membrane protein proteolysis#GO:0033619;cellular process#GO:0009987;cell communication#GO:0007154;protein metabolic process#GO:0019538;proteolysis#GO:0006508;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238 cell junction#GO:0030054;synaptic membrane#GO:0097060;cellular anatomical structure#GO:0110165;synapse#GO:0045202;plasma membrane region#GO:0098590;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 protease#PC00190;protein modifying enzyme#PC00260 Notch signaling pathway#P00045>TACE#P01105;Alzheimer disease-amyloid secretase pathway#P00003>ADAM10#P00108 HUMAN|HGNC=3333|UniProtKB=P54849 P54849 EMP1 PTHR10671:SF6 EPITHELIAL MEMBRANE PROTEIN-RELATED EPITHELIAL MEMBRANE PROTEIN 1 cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection assembly#GO:0120031;bleb assembly#GO:0032060;cell projection organization#GO:0030030;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;cell projection assembly#GO:0030031;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 cytoskeletal protein#PC00085 HUMAN|HGNC=8951|UniProtKB=P07093 P07093 SERPINE2 PTHR11461:SF48 SERINE PROTEASE INHIBITOR, SERPIN GLIA-DERIVED NEXIN serine-type endopeptidase inhibitor activity#GO:0004867;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;peptidase regulator activity#GO:0061134;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866;enzyme inhibitor activity#GO:0004857 negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of protein metabolic process#GO:0051246;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;regulation of proteolysis#GO:0030162;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of protein metabolic process#GO:0051248;negative regulation of metabolic process#GO:0009892;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HUMAN|HGNC=806|UniProtKB=P54709 P54709 ATP1B3 PTHR11523:SF47 SODIUM/POTASSIUM-DEPENDENT ATPASE BETA SUBUNIT SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA-3 ATPase activator activity#GO:0001671;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772 import across plasma membrane#GO:0098739;inorganic ion import across plasma membrane#GO:0099587;metal ion transport#GO:0030001;homeostatic process#GO:0042592;export from cell#GO:0140352;intracellular monoatomic ion homeostasis#GO:0006873;sodium ion transport#GO:0006814;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;potassium ion homeostasis#GO:0055075;monoatomic ion transport#GO:0006811;inorganic ion homeostasis#GO:0098771;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;establishment of localization#GO:0051234;import into cell#GO:0098657;potassium ion import across plasma membrane#GO:1990573;cellular homeostasis#GO:0019725;inorganic cation import across plasma membrane#GO:0098659;intracellular chemical homeostasis#GO:0055082;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;transport#GO:0006810;chemical homeostasis#GO:0048878 transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;ATPase dependent transmembrane transport complex#GO:0098533;membrane protein complex#GO:0098796;membrane#GO:0016020;cation-transporting ATPase complex#GO:0090533;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886 primary active transporter#PC00068;transporter#PC00227 HUMAN|HGNC=10424|UniProtKB=P62701 P62701 RPS4X PTHR11581:SF35 30S/40S RIBOSOMAL PROTEIN S4 SMALL RIBOSOMAL SUBUNIT PROTEIN ES4, X ISOFORM structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 translation#GO:0006412;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;protein biosynthetic process#GO:0160307;gene expression#GO:0010467 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;cytosolic small ribosomal subunit#GO:0022627;small ribosomal subunit#GO:0015935;intracellular organelle#GO:0043229;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;cytosol#GO:0005829;cytosolic ribosome#GO:0022626;ribosome#GO:0005840 ribosomal protein#PC00202 HUMAN|HGNC=23332|UniProtKB=Q9UBI1 Q9UBI1 COMMD3 PTHR31159:SF1 COMM DOMAIN-CONTAINING PROTEIN 3 COMM DOMAIN-CONTAINING PROTEIN 3 protein complex scaffold activity#GO:0140378;structural molecule activity#GO:0005198 protein-containing complex#GO:0032991 HUMAN|HGNC=27414|UniProtKB=Q7Z6I6 Q7Z6I6 ARHGAP30 PTHR15729:SF12 CDC42 GTPASE-ACTIVATING PROTEIN RHO GTPASE-ACTIVATING PROTEIN 30 molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;enzyme activator activity#GO:0008047 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;intracellular signaling cassette#GO:0141124;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;signaling#GO:0023052;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 GTPase-activating protein#PC00257;protein-binding activity modulator#PC00095 HUMAN|HGNC=1273|UniProtKB=P0DPI2 P0DPI2 GATD3 PTHR10224:SF9 ES1 PROTEIN HOMOLOG, MITOCHONDRIAL GLUTAMINE AMIDOTRANSFERASE-LIKE CLASS 1 DOMAIN-CONTAINING PROTEIN 3, MITOCHONDRIAL HUMAN|HGNC=11378|UniProtKB=Q9UHE8 Q9UHE8 STEAP1 PTHR14239:SF3 DUDULIN-RELATED STEAP FAMILY MEMBER 1B-RELATED ferric-chelate reductase activity#GO:0000293;catalytic activity#GO:0003824;oxidoreductase activity, acting on metal ions#GO:0016722;oxidoreductase activity#GO:0016491 monoatomic cation transport#GO:0006812;localization#GO:0051179;establishment of localization#GO:0051234;metal ion transport#GO:0030001;monoatomic ion transport#GO:0006811;transport#GO:0006810;transition metal ion transport#GO:0000041 intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;vesicle#GO:0031982;cell periphery#GO:0071944;intracellular vesicle#GO:0097708;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 reductase#PC00198 HUMAN|HGNC=25679|UniProtKB=Q9BSB4 Q9BSB4 ATG101 PTHR13292:SF0 AUTOPHAGY-RELATED PROTEIN 101 AUTOPHAGY-RELATED PROTEIN 101 binding#GO:0005488;kinase binding#GO:0019900;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;protein binding#GO:0005515 vacuole organization#GO:0007033;autophagosome assembly#GO:0000045;process utilizing autophagic mechanism#GO:0061919;cellular component organization or biogenesis#GO:0071840;organelle assembly#GO:0070925;metabolic process#GO:0008152;macroautophagy#GO:0016236;catabolic process#GO:0009056;cellular component assembly#GO:0022607;autophagy#GO:0006914;cellular process#GO:0009987;autophagosome organization#GO:1905037;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular component organization#GO:0016043 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494;phagophore assembly site#GO:0000407;transferase complex#GO:1990234;transferase complex, transferring phosphorus-containing groups#GO:0061695;serine/threonine protein kinase complex#GO:1902554;intracellular anatomical structure#GO:0005622;protein kinase complex#GO:1902911 HUMAN|HGNC=11714|UniProtKB=P28347 P28347 TEAD1 PTHR11834:SF4 TRANSCRIPTIONAL ENHANCER FACTOR TEF RELATED TRANSCRIPTIONAL ENHANCER FACTOR TEF-1 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 signaling#GO:0023052;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;intracellular signal transduction#GO:0035556;regulation of RNA metabolic process#GO:0051252;cell communication#GO:0007154;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;embryonic organ development#GO:0048568;animal gross anatomical part developmental process#GO:0160108;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;embryo development#GO:0009790;hippo signaling#GO:0035329;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;multicellular organism development#GO:0007275;animal organ development#GO:0048513;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667 helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=20276|UniProtKB=Q86XA9 Q86XA9 HEATR5A PTHR21663:SF1 HYPOTHETICAL HEAT DOMAIN-CONTAINING HEAT REPEAT-CONTAINING PROTEIN 5A establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule localization#GO:0033036;retrograde transport, endosome to Golgi#GO:0042147;cytosolic transport#GO:0016482;vesicle-mediated transport#GO:0016192;transport#GO:0006810;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;endosomal transport#GO:0016197;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641 intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;endocytic vesicle#GO:0030139;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=2087|UniProtKB=O96005 O96005 CLPTM1 PTHR21347:SF14 CLEFT LIP AND PALATE ASSOCIATED TRANSMEMBRANE PROTEIN-RELATED LIPID SCRAMBLASE CLPTM1-RELATED membrane#GO:0016020;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 HUMAN|HGNC=400|UniProtKB=Q13740 Q13740 ALCAM PTHR11973:SF2 CELL SURFACE GLYCOPROTEIN MUC18-RELATED CD166 ANTIGEN cellular process#GO:0009987;neuron projection development#GO:0031175;plasma membrane bounded cell projection organization#GO:0120036;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;developmental process#GO:0032502;neuron differentiation#GO:0030182;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cellular component organization#GO:0016043;cell development#GO:0048468;cell projection organization#GO:0030030;cell differentiation#GO:0030154;generation of neurons#GO:0048699;cell adhesion#GO:0007155;animal gross anatomical part developmental process#GO:0160108;neuron development#GO:0048666;system development#GO:0048731;anatomical structure development#GO:0048856 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 immunoglobulin superfamily cell adhesion molecule#PC00125;cell adhesion molecule#PC00069 HUMAN|HGNC=1867|UniProtKB=P41208 P41208 CETN2 PTHR23050:SF305 CALCIUM BINDING PROTEIN CENTRIN-2 cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094 DNA damage response#GO:0006974;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;microtubule organizing center organization#GO:0031023;microtubule-based process#GO:0007017;centrosome duplication#GO:0051298;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;response to stress#GO:0006950;nucleotide-excision repair#GO:0006289;cytoskeleton organization#GO:0007010;nucleobase-containing compound metabolic process#GO:0006139;cellular component assembly#GO:0022607;cellular response to stress#GO:0033554;centriole replication#GO:0007099;organelle assembly#GO:0070925;microtubule cytoskeleton organization#GO:0000226;centrosome cycle#GO:0007098;cellular response to stimulus#GO:0051716;cell cycle process#GO:0022402;cell cycle#GO:0007049;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;response to stimulus#GO:0050896 cytoskeleton#GO:0005856;centrosome#GO:0005813;microtubule organizing center#GO:0005815;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;microtubule cytoskeleton#GO:0015630;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;centriole#GO:0005814;intracellular membraneless organelle#GO:0043232 calcium-binding protein#PC00060;calmodulin-related#PC00061 HUMAN|HGNC=4975|UniProtKB=Q95460 Q95460 MR1 PTHR16675:SF242 MHC CLASS I-RELATED MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I-RELATED PROTEIN 1 immune system process#GO:0002376;immune response#GO:0006955;response to stimulus#GO:0050896 cell surface#GO:0009986;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;side of membrane#GO:0098552;extracellular region#GO:0005576;external side of plasma membrane#GO:0009897 defense/immunity protein#PC00090;major histocompatibility complex protein#PC00149 HUMAN|HGNC=33128|UniProtKB=Q86TX2 Q86TX2 ACOT1 PTHR10824:SF44 ACYL-COENZYME A THIOESTERASE-RELATED ACYL-COENZYME A THIOESTERASE 1-RELATED hydrolase activity, acting on ester bonds#GO:0016788;thiolester hydrolase activity#GO:0016790;deacylase activity#GO:0160215;acyl-CoA hydrolase activity#GO:0016289;fatty acyl-CoA hydrolase activity#GO:0047617;catalytic activity#GO:0003824;hydrolase activity#GO:0016787 nucleoside phosphate metabolic process#GO:0006753;very long-chain fatty acid metabolic process#GO:0000038;small molecule metabolic process#GO:0044281;purine-containing compound metabolic process#GO:0072521;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;monocarboxylic acid metabolic process#GO:0032787;oxoacid metabolic process#GO:0043436;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;sulfur compound metabolic process#GO:0006790;long-chain fatty acid metabolic process#GO:0001676;organophosphate metabolic process#GO:0019637;nucleobase-containing small molecule metabolic process#GO:0055086;acyl-CoA metabolic process#GO:0006637;lipid metabolic process#GO:0006629;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;microbody#GO:0042579;mitochondrion#GO:0005739;peroxisome#GO:0005777 esterase#PC00097 HUMAN|HGNC=20635|UniProtKB=Q14997 Q14997 PSME4 PTHR32170:SF5 PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4 PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4 peptidase regulator activity#GO:0061134;peptidase activator activity#GO:0016504;enzyme activator activity#GO:0008047;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234 proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;cellular process#GO:0009987;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057 endopeptidase complex#GO:1905369;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;proteasome complex#GO:0000502;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;peptidase complex#GO:1905368;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=10894|UniProtKB=O14744 O14744 PRMT5 PTHR10738:SF0 PROTEIN ARGININE N-METHYLTRANSFERASE 5 PROTEIN ARGININE N-METHYLTRANSFERASE 5 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 nucleus#GO:0005634;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HUMAN|HGNC=18967|UniProtKB=Q92611 Q92611 EDEM1 PTHR45679:SF5 ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2 ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 1 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;response to topologically incorrect protein#GO:0035966;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;response to unfolded protein#GO:0006986;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular response to unfolded protein#GO:0034620;response to endoplasmic reticulum stress#GO:0034976;cellular response to topologically incorrect protein#GO:0035967;cellular response to stress#GO:0033554;biological regulation#GO:0065007;response to stress#GO:0006950;endoplasmic reticulum unfolded protein response#GO:0030968;cellular process#GO:0009987;signal transduction#GO:0007165 HUMAN|HGNC=11741|UniProtKB=Q00059 Q00059 TFAM PTHR48112:SF36 HIGH MOBILITY GROUP PROTEIN DSP1 TRANSCRIPTION FACTOR A, MITOCHONDRIAL transcription regulator activity#GO:0140110 cellular component organization#GO:0016043;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;chromatin remodeling#GO:0006338;DNA-templated transcription#GO:0006351;DNA-templated transcription initiation#GO:0006352;nucleic acid biosynthetic process#GO:0141187;mitochondrial gene expression#GO:0140053;mitochondrial RNA metabolic process#GO:0000959;RNA metabolic process#GO:0016070;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;chromatin organization#GO:0006325;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;mitochondrial transcription#GO:0006390;gene expression#GO:0010467;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170 intracellular membrane-bounded organelle#GO:0043231;nucleoid#GO:0009295;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;mitochondrial nucleoid#GO:0042645;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;intracellular organelle lumen#GO:0070013;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;membraneless organelle#GO:0043228 HMG box transcription factor#PC00024;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=3518|UniProtKB=O43909 O43909 EXTL3 PTHR11062:SF73 EXOSTOSIN HEPARAN SULFATE GLYCOSYLTRANSFERASE -RELATED EXOSTOSIN-LIKE 3 glycosyltransferase#PC00111;transferase#PC00220 HUMAN|HGNC=10628|UniProtKB=P16619 P16619 CCL3L1 PTHR12015:SF151 SMALL INDUCIBLE CYTOKINE A C-C MOTIF CHEMOKINE 3-LIKE 1 molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;G protein-coupled receptor binding#GO:0001664;chemokine activity#GO:0008009;chemokine receptor binding#GO:0042379;protein binding#GO:0005515;molecular function activator activity#GO:0140677;cytokine activity#GO:0005125;signaling receptor binding#GO:0005102;cytokine receptor binding#GO:0005126;binding#GO:0005488 leukocyte migration#GO:0050900;regulation of cell migration#GO:0030334;myeloid leukocyte migration#GO:0097529;response to external stimulus#GO:0009605;positive regulation of locomotion#GO:0040017;leukocyte chemotaxis#GO:0030595;defense response#GO:0006952;positive regulation of cellular process#GO:0048522;immune response#GO:0006955;positive regulation of cell migration#GO:0030335;cell migration#GO:0016477;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;response to other organism#GO:0051707;cytokine-mediated signaling pathway#GO:0019221;chemotaxis#GO:0006935;inflammatory response#GO:0006954;chemokine-mediated signaling pathway#GO:0070098;regulation of cell motility#GO:2000145;cell communication#GO:0007154;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;cell chemotaxis#GO:0060326;cellular response to stimulus#GO:0051716;cell motility#GO:0048870;regulation of cellular process#GO:0050794;response to external biotic stimulus#GO:0043207;locomotion#GO:0040011;cellular response to chemokine#GO:1990869;antimicrobial humoral response#GO:0019730;humoral immune response#GO:0006959;cell surface receptor signaling pathway#GO:0007166;response to chemokine#GO:1990868;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;defense response to symbiont#GO:0140546;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;response to chemical#GO:0042221;response to cytokine#GO:0034097;taxis#GO:0042330;defense response to other organism#GO:0098542;granulocyte migration#GO:0097530;cellular response to chemical stimulus#GO:0070887;immune system process#GO:0002376;G protein-coupled receptor signaling pathway#GO:0007186;response to peptide#GO:1901652;positive regulation of cell motility#GO:2000147;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;granulocyte chemotaxis#GO:0071621;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 cytokine#PC00083 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CHK#P00856 HUMAN|HGNC=12766|UniProtKB=O96028 O96028 NSD2 PTHR22884:SF293 SET DOMAIN PROTEINS HISTONE-LYSINE N-METHYLTRANSFERASE NSD2 lysine N-methyltransferase activity#GO:0016278;histone H3 methyltransferase activity#GO:0140938;histone modifying activity#GO:0140993;histone methyltransferase activity#GO:0042054;protein-lysine N-methyltransferase activity#GO:0016279;N-methyltransferase activity#GO:0008170;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;catalytic activity, acting on a protein#GO:0140096;histone H3K36 methyltransferase activity#GO:0046975;protein methyltransferase activity#GO:0008276;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring one-carbon groups#GO:0016741 regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694;nucleus#GO:0005634;chromatin#GO:0000785;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HUMAN|HGNC=26309|UniProtKB=Q86VU5 Q86VU5 COMTD1 PTHR10509:SF14 O-METHYLTRANSFERASE-RELATED CATECHOL O-METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN 1 transferase activity#GO:0016740;catalytic activity#GO:0003824;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;transferase activity, transferring one-carbon groups#GO:0016741 methyltransferase#PC00155 HUMAN|HGNC=25639|UniProtKB=Q49AR2 Q49AR2 C5orf22 PTHR13225:SF3 MISEXPRESSION SUPPRESSOR OF RAS 6 UPF0489 PROTEIN C5ORF22 HUMAN|HGNC=17350|UniProtKB=O60508 O60508 CDC40 PTHR43979:SF1 PRE-MRNA-PROCESSING FACTOR 17 PRE-MRNA-PROCESSING FACTOR 17 metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071 nucleus#GO:0005634;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;catalytic step 2 spliceosome#GO:0071013 RNA splicing factor#PC00148 HUMAN|HGNC=15587|UniProtKB=Q4VX76 Q4VX76 SYTL3 PTHR45716:SF1 BITESIZE, ISOFORM I SYNAPTOTAGMIN-LIKE PROTEIN 3 binding#GO:0005488;signaling receptor binding#GO:0005102;protein binding#GO:0005515 secretion#GO:0046903;establishment of localization#GO:0051234;localization#GO:0051179;exocytosis#GO:0006887;secretion by cell#GO:0032940;transport#GO:0006810;vesicle-mediated transport#GO:0016192;export from cell#GO:0140352;cellular process#GO:0009987 exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;secretory vesicle#GO:0099503;cell periphery#GO:0071944;endomembrane system#GO:0012505;transport vesicle#GO:0030133;cytoplasm#GO:0005737;plasma membrane#GO:0005886 membrane traffic protein#PC00150;membrane trafficking regulatory protein#PC00151 Synaptic vesicle trafficking#P05734>Synaptotagmin#P05769 HUMAN|HGNC=10000|UniProtKB=P49798 P49798 RGS4 PTHR10845:SF184 REGULATOR OF G PROTEIN SIGNALING REGULATOR OF G PROTEIN SIGNALING 4 enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234 negative regulation of signaling#GO:0023057;negative regulation of cellular process#GO:0048523;regulation of G protein-coupled receptor signaling pathway#GO:0008277;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;negative regulation of G protein-coupled receptor signaling pathway#GO:0045744;regulation of biological process#GO:0050789;negative regulation of response to stimulus#GO:0048585;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;negative regulation of signal transduction#GO:0009968 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell periphery#GO:0071944;cytoplasmic side of membrane#GO:0098562;membrane#GO:0016020;cytoplasmic side of plasma membrane#GO:0009898 GTPase-activating protein#PC00257 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>RGS#P00833;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>RGS#P00704;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>RGS#P00731 HUMAN|HGNC=16946|UniProtKB=Q92791 Q92791 P3H4 PTHR13986:SF4 PROTEIN LYSINE HYDROXYLATION COMPLEX COMPONENT ENDOPLASMIC RETICULUM PROTEIN SC65 protein-containing complex binding#GO:0044877;binding#GO:0005488;collagen binding#GO:0005518 cellular component organization#GO:0016043;extracellular structure organization#GO:0043062;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;collagen fibril organization#GO:0030199;extracellular matrix organization#GO:0030198;external encapsulating structure organization#GO:0045229 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 protein modifying enzyme#PC00260 HUMAN|HGNC=10755|UniProtKB=O75920 O75920 SERF1A PTHR13596:SF1 SMALL EDRK-RICH FACTOR 1 SMALL EDRK-RICH FACTOR 1 HUMAN|HGNC=22979|UniProtKB=P09131 P09131 SLC10A3 PTHR10361:SF3 SODIUM-BILE ACID COTRANSPORTER P3 PROTEIN monoatomic cation transmembrane transporter activity#GO:0008324;bile acid transmembrane transporter activity#GO:0015125;solute:sodium symporter activity#GO:0015370;carboxylic acid transmembrane transporter activity#GO:0046943;symporter activity#GO:0015293;sodium ion transmembrane transporter activity#GO:0015081;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;secondary active transmembrane transporter activity#GO:0015291 lipid transport#GO:0006869;macromolecule localization#GO:0033036;organic hydroxy compound transport#GO:0015850;monocarboxylic acid transport#GO:0015718;localization#GO:0051179;establishment of localization#GO:0051234;bile acid and bile salt transport#GO:0015721;organic acid transport#GO:0015849;carboxylic acid transport#GO:0046942;transport#GO:0006810;lipid localization#GO:0010876 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 primary active transporter#PC00068 HUMAN|HGNC=28324|UniProtKB=Q96BF3 Q96BF3 TMIGD2 PTHR12231:SF266 CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN TRANSMEMBRANE AND IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN 2 protein binding#GO:0005515;cell adhesion molecule binding#GO:0050839;cell adhesion mediator activity#GO:0098631;binding#GO:0005488 cell-cell adhesion#GO:0098609;cellular process#GO:0009987;cell adhesion#GO:0007155 cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005;cell junction#GO:0030054 cell adhesion molecule#PC00069;immunoglobulin superfamily cell adhesion molecule#PC00125 HUMAN|HGNC=17482|UniProtKB=Q9UNW8 Q9UNW8 GPR132 PTHR24234:SF7 LYSOPHOSPHATIDIC ACID RECEPTOR 5/SPHINGOSYLPHOSPHORYLCHOLINE RECEPTOR G PROTEIN-COUPLED RECEPTOR 132-RELATED cell cycle process#GO:0022402;regulation of biological process#GO:0050789;negative regulation of cell cycle phase transition#GO:1901988;regulation of cell cycle phase transition#GO:1901987;negative regulation of biological process#GO:0048519;cell cycle#GO:0007049;regulation of cell cycle#GO:0051726;regulation of cellular process#GO:0050794;cell cycle phase transition#GO:0044770;mitotic cell cycle#GO:0000278;mitotic cell cycle phase transition#GO:0044772;negative regulation of mitotic cell cycle#GO:0045930;regulation of G2/M transition of mitotic cell cycle#GO:0010389;regulation of mitotic cell cycle phase transition#GO:1901990;cellular process#GO:0009987;regulation of mitotic cell cycle#GO:0007346;cell cycle G1/S phase transition#GO:0044843;regulation of cell cycle G2/M phase transition#GO:1902749;biological regulation#GO:0065007;regulation of cell cycle process#GO:0010564;negative regulation of G2/M transition of mitotic cell cycle#GO:0010972;negative regulation of mitotic cell cycle phase transition#GO:1901991;negative regulation of cell cycle process#GO:0010948;negative regulation of cellular process#GO:0048523;G1/S transition of mitotic cell cycle#GO:0000082;negative regulation of cell cycle G2/M phase transition#GO:1902750;mitotic cell cycle process#GO:1903047;negative regulation of cell cycle#GO:0045786 G-protein coupled receptor#PC00021 HUMAN|HGNC=24550|UniProtKB=Q9H8H3 Q9H8H3 TMT1A PTHR42912:SF93 METHYLTRANSFERASE THIOL S-METHYLTRANSFERASE TMT1A transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring one-carbon groups#GO:0016741;methyltransferase activity#GO:0008168 methyltransferase#PC00155;transferase#PC00220 HUMAN|HGNC=10251|UniProtKB=Q13464 Q13464 ROCK1 PTHR22988:SF33 MYOTONIC DYSTROPHY S/T KINASE-RELATED RHO-ASSOCIATED PROTEIN KINASE 1 transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 multicellular organismal process#GO:0032501;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;regulation of actin filament-based process#GO:0032970;developmental process#GO:0032502;mitotic cell cycle process#GO:1903047;cell cycle#GO:0007049;cellular response to stimulus#GO:0051716;cell division#GO:0051301;mitotic cytokinesis#GO:0000281;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;mitotic cell cycle#GO:0000278;regulation of cytoskeleton organization#GO:0051493;cortical cytoskeleton organization#GO:0030865;regulation of cell junction assembly#GO:1901888;actin filament-based process#GO:0030029;anatomical structure development#GO:0048856;cortical actin cytoskeleton organization#GO:0030866;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;organelle organization#GO:0006996;cellular process#GO:0009987;signal transduction#GO:0007165;intracellular signaling cassette#GO:0141124;embryo development#GO:0009790;regulation of actin cytoskeleton organization#GO:0032956;cytoskeleton organization#GO:0007010;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;embryonic morphogenesis#GO:0048598;cellular component organization#GO:0016043;cell cycle process#GO:0022402;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;response to stimulus#GO:0050896;regulation of cellular component organization#GO:0051128;regulation of cellular component biogenesis#GO:0044087;actomyosin structure organization#GO:0031032;signaling#GO:0023052;cytokinesis#GO:0000910;Rho protein signal transduction#GO:0007266;cytoskeleton-dependent cytokinesis#GO:0061640 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 Cytoskeletal regulation by Rho GTPase#P00016>ROCK#P00519;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>ROCK#P00881;CCKR signaling map#P06959>ROCK1#P07033 HUMAN|HGNC=37216|UniProtKB=A6NK58 A6NK58 LIPT2 PTHR10993:SF7 OCTANOYLTRANSFERASE OCTANOYL-[ACYL-CARRIER-PROTEIN]:PROTEIN N-OCTANOYLTRANSFERASE LIPT2, MITOCHONDRIAL acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 transferase#PC00220 Lipoate_biosynthesis#P02750>Lipoyl-protein ligase#P03003 HUMAN|HGNC=14275|UniProtKB=Q9BYD6 Q9BYD6 MRPL1 PTHR36427:SF5 54S RIBOSOMAL PROTEIN L1, MITOCHONDRIAL LARGE RIBOSOMAL SUBUNIT PROTEIN UL1M mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;structural constituent of ribosome#GO:0003735;RNA binding#GO:0003723;structural molecule activity#GO:0005198 biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;post-transcriptional regulation of gene expression#GO:0010608 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;mitochondrion#GO:0005739;organelle lumen#GO:0043233;mitochondrial ribosome#GO:0005761;intracellular anatomical structure#GO:0005622;organellar ribosome#GO:0000313;membrane-bounded organelle#GO:0043227;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;large ribosomal subunit#GO:0015934;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;membrane-enclosed lumen#GO:0031974;mitochondrial large ribosomal subunit#GO:0005762;membraneless organelle#GO:0043228 ribosomal protein#PC00202;translational protein#PC00263 HUMAN|HGNC=9346|UniProtKB=O75626 O75626 PRDM1 PTHR16515:SF59 PR DOMAIN ZINC FINGER PROTEIN PR DOMAIN ZINC FINGER PROTEIN 1 biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218;C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HUMAN|HGNC=6014|UniProtKB=P05112 P05112 IL4 PTHR47401:SF1 INTERLEUKIN-4 INTERLEUKIN-4 regulation of response to external stimulus#GO:0032101;response to cytokine#GO:0034097;positive regulation of macromolecule metabolic process#GO:0010604;response to chemical#GO:0042221;negative regulation of response to external stimulus#GO:0032102;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cell surface receptor signaling pathway#GO:0007166;response to stimulus#GO:0050896;signaling#GO:0023052;negative regulation of biological process#GO:0048519;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;response to peptide#GO:1901652;negative regulation of response to stimulus#GO:0048585;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of response to stress#GO:0080134;regulation of response to stimulus#GO:0048583;negative regulation of inflammatory response#GO:0050728;negative regulation of defense response#GO:0031348;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;cellular response to stimulus#GO:0051716;regulation of DNA-templated transcription#GO:0006355;cell communication#GO:0007154;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;cytokine-mediated signaling pathway#GO:0019221;regulation of inflammatory response#GO:0050727;regulation of defense response#GO:0031347;regulation of immune response#GO:0050776 interleukin superfamily#PC00128 Interleukin signaling pathway#P00036>Interleukin#P00970 HUMAN|HGNC=2438|UniProtKB=P09919 P09919 CSF3 PTHR10511:SF2 GRANULOCYTE COLONY-STIMULATING FACTOR GRANULOCYTE COLONY-STIMULATING FACTOR molecular function activator activity#GO:0140677;protein binding#GO:0005515;cytokine receptor binding#GO:0005126;binding#GO:0005488;signaling receptor binding#GO:0005102;cytokine activity#GO:0005125;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;growth factor receptor binding#GO:0070851;growth factor activity#GO:0008083;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018 developmental process#GO:0032502;positive regulation of developmental process#GO:0051094;regulation of cell differentiation#GO:0045595;cellular developmental process#GO:0048869;positive regulation of cellular process#GO:0048522;positive regulation of myeloid cell differentiation#GO:0045639;regulation of cell development#GO:0060284;biological regulation#GO:0065007;hemopoiesis#GO:0030097;cytokine-mediated signaling pathway#GO:0019221;regulation of hemopoiesis#GO:1903706;cell communication#GO:0007154;anatomical structure development#GO:0048856;cellular response to stimulus#GO:0051716;regulation of developmental process#GO:0050793;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;positive regulation of cell differentiation#GO:0045597;cell surface receptor signaling pathway#GO:0007166;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of multicellular organismal process#GO:0051239;response to cytokine#GO:0034097;response to chemical#GO:0042221;regulation of myeloid cell differentiation#GO:0045637;response to peptide#GO:1901652;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;regulation of multicellular organismal development#GO:2000026;mononuclear cell differentiation#GO:1903131;leukocyte differentiation#GO:0002521;signaling#GO:0023052;cell development#GO:0048468;cell differentiation#GO:0030154;response to stimulus#GO:0050896;myeloid cell differentiation#GO:0030099 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=994|UniProtKB=O43521 O43521 BCL2L11 PTHR12044:SF9 BCL2 INTERACTING MEDIATOR OF CELL DEATH BCL-2-LIKE PROTEIN 11 regulation of apoptotic process#GO:0042981;meiotic cell cycle#GO:0051321;positive regulation of apoptotic process#GO:0043065;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;response to stress#GO:0006950;organelle organization#GO:0006996;intrinsic apoptotic signaling pathway in response to DNA damage#GO:0008630;cellular response to stress#GO:0033554;nuclear division#GO:0000280;intrinsic apoptotic signaling pathway#GO:0097193;apoptotic process#GO:0006915;cell cycle process#GO:0022402;regulation of biological process#GO:0050789;meiosis I#GO:0007127;meiotic cell cycle process#GO:1903046;cellular component organization#GO:0016043;regulation of programmed cell death#GO:0043067;signaling#GO:0023052;positive regulation of programmed cell death#GO:0043068;response to stimulus#GO:0050896;DNA damage response#GO:0006974;meiotic nuclear division#GO:0140013;apoptotic signaling pathway#GO:0097190;positive regulation of cellular process#GO:0048522;biological regulation#GO:0065007;sexual reproduction#GO:0019953;response to endoplasmic reticulum stress#GO:0034976;meiosis I cell cycle process#GO:0061982;intracellular signal transduction#GO:0035556;organelle fission#GO:0048285;cell communication#GO:0007154;cell death#GO:0008219;cellular response to stimulus#GO:0051716;programmed cell death#GO:0012501;cell cycle#GO:0007049;reproductive process#GO:0022414;regulation of cellular process#GO:0050794 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;mitochondrion#GO:0005739 Apoptosis signaling pathway#P00006>Bim#P00325 HUMAN|HGNC=7629|UniProtKB=E9PAV3 E9PAV3 NACA PTHR21713:SF3 NASCENT POLYPEPTIDE ASSOCIATED COMPLEX ALPHA SUBUNIT-RELATED NASCENT POLYPEPTIDE-ASSOCIATED COMPLEX SUBUNIT ALPHA, MUSCLE-SPECIFIC FORM localization within membrane#GO:0051668;protein targeting to membrane#GO:0006612;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;establishment of protein localization#GO:0045184;cellular process#GO:0009987;establishment of protein localization to membrane#GO:0090150;protein targeting#GO:0006605 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=4222|UniProtKB=Q7Z4P5 Q7Z4P5 GDF7 PTHR11848:SF160 TGF-BETA FAMILY GROWTH_DIFFERENTIATION FACTOR 7 molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;cytokine activity#GO:0005125 cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;cell surface receptor signaling pathway#GO:0007166;response to BMP#GO:0071772;cellular response to BMP stimulus#GO:0071773;developmental process#GO:0032502;animal organ development#GO:0048513;multicellular organism development#GO:0007275;renal system development#GO:0072001;kidney development#GO:0001822;cellular process#GO:0009987;signal transduction#GO:0007165;multicellular organismal process#GO:0032501;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;biological regulation#GO:0065007;animal gross anatomical part developmental process#GO:0160108;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cellular response to growth factor stimulus#GO:0071363;system development#GO:0048731;response to endogenous stimulus#GO:0009719;BMP signaling pathway#GO:0030509;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;response to growth factor#GO:0070848;signaling#GO:0023052 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 growth factor#PC00112 TGF-beta signaling pathway#P00052>TGFbeta#P01286 HUMAN|HGNC=24937|UniProtKB=Q9Y3E1 Q9Y3E1 HDGFL3 PTHR12550:SF84 HEPATOMA-DERIVED GROWTH FACTOR-RELATED HEPATOMA-DERIVED GROWTH FACTOR-RELATED PROTEIN 3 cellular process#GO:0009987;cellular component organization#GO:0016043;chromatin remodeling#GO:0006338;chromatin organization#GO:0006325;cellular component organization or biogenesis#GO:0071840 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HUMAN|HGNC=25332|UniProtKB=Q8NDD1 Q8NDD1 FSAF1 PTHR28366:SF1 CHROMOSOME 1 OPEN READING FRAME 131 40S SMALL SUBUNIT PROCESSOME ASSEMBLY FACTOR 1 HUMAN|HGNC=23198|UniProtKB=Q6ZWL3 Q6ZWL3 CYP4V2 PTHR24291:SF189 CYTOCHROME P450 FAMILY 4 CYTOCHROME P450 4V2 metabolite interconversion enzyme#PC00262;oxygenase#PC00177;oxidoreductase#PC00176 HUMAN|HGNC=6553|UniProtKB=P41159 P41159 LEP PTHR11724:SF1 LEPTIN LEPTIN protein binding#GO:0005515;molecular function activator activity#GO:0140677;hormone activity#GO:0005179;signaling receptor binding#GO:0005102;binding#GO:0005488;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018 cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;negative regulation of biological process#GO:0048519;signaling#GO:0023052;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;cellular response to hormone stimulus#GO:0032870;response to oxygen-containing compound#GO:1901700;regulation of signaling#GO:0023051;cellular response to chemical stimulus#GO:0070887;response to peptide#GO:1901652;regulation of biological quality#GO:0065008;positive regulation of signaling#GO:0023056;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;response to hormone#GO:0009725;response to cytokine#GO:0034097;response to chemical#GO:0042221;cell surface receptor signaling pathway#GO:0007166;metabolic process#GO:0008152;cellular response to stimulus#GO:0051716;response to insulin#GO:0032868;positive regulation of signal transduction#GO:0009967;primary metabolic process#GO:0044238;regulation of cell communication#GO:0010646;regulation of receptor signaling pathway via STAT#GO:1904892;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;energy reserve metabolic process#GO:0006112;cytokine-mediated signaling pathway#GO:0019221;positive regulation of receptor signaling pathway via JAK-STAT#GO:0046427;response to nitrogen compound#GO:1901698;cell communication#GO:0007154;positive regulation of cellular process#GO:0048522;response to nutrient levels#GO:0031667;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;response to peptide hormone#GO:0043434;positive regulation of response to stimulus#GO:0048584;negative regulation of response to stimulus#GO:0048585;generation of precursor metabolites and energy#GO:0006091;regulation of receptor signaling pathway via JAK-STAT#GO:0046425;lipid metabolic process#GO:0006629;regulation of response to stimulus#GO:0048583;energy derivation by oxidation of organic compounds#GO:0015980 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 peptide hormone#PC00179 HUMAN|HGNC=16684|UniProtKB=Q96EL3 Q96EL3 MRPL53 PTHR33618:SF1 39S RIBOSOMAL PROTEIN L53, MITOCHONDRIAL LARGE RIBOSOMAL SUBUNIT PROTEIN ML53 organelle lumen#GO:0043233;ribosome#GO:0005840;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;large ribosomal subunit#GO:0015934;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;organellar ribosome#GO:0000313;intracellular anatomical structure#GO:0005622;mitochondrial ribosome#GO:0005761;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;membraneless organelle#GO:0043228;mitochondrial large ribosomal subunit#GO:0005762 ribosomal protein#PC00202 HUMAN|HGNC=19392|UniProtKB=Q8WXH5 Q8WXH5 SOCS4 PTHR10155:SF21 PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT SUPPRESSOR OF CYTOKINE SIGNALING 4 cell communication#GO:0007154;response to peptide#GO:1901652;cytokine-mediated signaling pathway#GO:0019221;cell surface receptor signaling pathway#GO:0007166;regulation of cellular process#GO:0050794;response to cytokine#GO:0034097;response to chemical#GO:0042221;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;signal transduction#GO:0007165 kinase modulator#PC00140 Interferon-gamma signaling pathway#P00035>SOCS#P00956;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>SOCS#P00879 HUMAN|HGNC=6321|UniProtKB=O14782 O14782 KIF3C PTHR24115:SF734 KINESIN-RELATED KINESIN-LIKE PROTEIN KIF3C cytoskeletal motor activity#GO:0003774;cytoskeletal protein binding#GO:0008092;hydrolase activity, acting on acid anhydrides#GO:0016817;protein binding#GO:0005515;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP-dependent activity#GO:0140657;ribonucleoside triphosphate phosphatase activity#GO:0017111;isomerase activity#GO:0016853;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;tubulin binding#GO:0015631;macromolecular conformation isomerase activity#GO:0120543;hydrolase activity#GO:0016787;microtubule motor activity#GO:0003777;ATP hydrolysis activity#GO:0016887;polypeptide conformation or assembly isomerase activity#GO:0120544;microtubule binding#GO:0008017 microtubule-based process#GO:0007017;cilium organization#GO:0044782;cellular component organization or biogenesis#GO:0071840;organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031;plasma membrane bounded cell projection organization#GO:0120036;microtubule-based movement#GO:0007018;cellular component assembly#GO:0022607;cell projection organization#GO:0030030;cellular process#GO:0009987;cell projection assembly#GO:0030031;cilium assembly#GO:0060271;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;microtubule#GO:0005874;microtubule cytoskeleton#GO:0015630;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoskeleton#GO:0005856;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=12112|UniProtKB=A0A0A6YYK6 A0A0A6YYK6 TRAV16 PTHR19367:SF51 T-CELL RECEPTOR ALPHA CHAIN V REGION T CELL RECEPTOR ALPHA VARIABLE 16 response to stimulus#GO:0050896;adaptive immune response#GO:0002250;immune system process#GO:0002376;immune response#GO:0006955 protein-containing complex#GO:0032991 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=24044|UniProtKB=Q5TYM5 Q5TYM5 FAM72A PTHR31841:SF1 PROTEIN FAM72A-RELATED PROTEIN FAM72A-RELATED cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=23139|UniProtKB=Q8IUQ0 Q8IUQ0 CLVS1 PTHR10174:SF72 ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED CLAVESIN-1 phosphatidylinositol bisphosphate binding#GO:1902936;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;anion binding#GO:0043168 cellular component organization#GO:0016043;organelle organization#GO:0006996;lysosome organization#GO:0007040;lytic vacuole organization#GO:0080171;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;vacuole organization#GO:0007033 endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;coated vesicle#GO:0030135;cytoplasmic vesicle#GO:0031410;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;clathrin-coated vesicle#GO:0030136;Golgi apparatus#GO:0005794;Golgi apparatus subcompartment#GO:0098791;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;endomembrane system#GO:0012505 transfer/carrier protein#PC00219 HUMAN|HGNC=2338|UniProtKB=P29762 P29762 CRABP1 PTHR11955:SF62 FATTY ACID BINDING PROTEIN CELLULAR RETINOIC ACID-BINDING PROTEIN 1 carboxylic acid binding#GO:0031406;small molecule binding#GO:0036094;anion binding#GO:0043168;binding#GO:0005488;ion binding#GO:0043167;organic acid binding#GO:0043177;fatty acid binding#GO:0005504;lipid binding#GO:0008289 lipid transport#GO:0006869;macromolecule localization#GO:0033036;monocarboxylic acid transport#GO:0015718;localization#GO:0051179;fatty acid transport#GO:0015908;establishment of localization#GO:0051234;carboxylic acid transport#GO:0046942;organic acid transport#GO:0015849;transport#GO:0006810;lipid localization#GO:0010876 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;cytosol#GO:0005829 transfer/carrier protein#PC00219 HUMAN|HGNC=1084|UniProtKB=Q12983 Q12983 BNIP3 PTHR15186:SF4 RE48077P BCL2_ADENOVIRUS E1B 19 KDA PROTEIN-INTERACTING PROTEIN 3 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 organelle organization#GO:0006996;reticulophagy#GO:0061709;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;autophagy#GO:0006914;cellular process#GO:0009987;mitochondrion organization#GO:0007005;biological regulation#GO:0065007;macroautophagy#GO:0016236;apoptotic mitochondrial changes#GO:0008637;metabolic process#GO:0008152;autophagy of mitochondrion#GO:0000422;regulation of apoptotic process#GO:0042981;positive regulation of apoptotic process#GO:0043065;cellular component organization or biogenesis#GO:0071840;mitophagy#GO:0000423;regulation of programmed cell death#GO:0043067;programmed cell death#GO:0012501;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;apoptotic process#GO:0006915;cell death#GO:0008219;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;positive regulation of programmed cell death#GO:0043068;process utilizing autophagic mechanism#GO:0061919 organelle envelope#GO:0031967;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;intracellular membrane-bounded organelle#GO:0043231;outer membrane#GO:0019867;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;mitochondrial envelope#GO:0005740;nucleus#GO:0005634;mitochondrial membrane#GO:0031966;endomembrane system#GO:0012505;organelle outer membrane#GO:0031968;cytoplasm#GO:0005737;nuclear envelope#GO:0005635;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;mitochondrial outer membrane#GO:0005741;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090 HUMAN|HGNC=29944|UniProtKB=Q9P273 Q9P273 TENM3 PTHR11219:SF65 TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE TENEURIN-3 protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 system development#GO:0048731;anatomical structure development#GO:0048856;synapse organization#GO:0050808;cell junction organization#GO:0034330;neurogenesis#GO:0022008;neuron projection guidance#GO:0097485;cellular developmental process#GO:0048869;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;plasma membrane bounded cell projection organization#GO:0120036;multicellular organismal process#GO:0032501;axon development#GO:0061564;axon guidance#GO:0007411;axonogenesis#GO:0007409;neuron development#GO:0048666;synaptic membrane adhesion#GO:0099560;generation of neurons#GO:0048699;cell adhesion#GO:0007155;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;cell morphogenesis#GO:0000902;cell differentiation#GO:0030154;cell projection organization#GO:0030030;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;cell projection morphogenesis#GO:0048858;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;cellular process#GO:0009987;cell-cell adhesion#GO:0098609;neuron projection development#GO:0031175 cell junction#GO:0030054;cell projection#GO:0042995;plasma membrane#GO:0005886;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165;synapse#GO:0045202;glutamatergic synapse#GO:0098978;neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=20101|UniProtKB=Q8N9W8 Q8N9W8 GARIN2 PTHR22574:SF6 FAMILY NOT NAMED GOLGI-ASSOCIATED RAB2 INTERACTOR PROTEIN 2 HUMAN|HGNC=25152|UniProtKB=Q9BSF4 Q9BSF4 TIMM29 PTHR21435:SF1 MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM29 MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM29 organelle organization#GO:0006996;mitochondrial membrane organization#GO:0007006;establishment of localization in cell#GO:0051649;inner mitochondrial membrane organization#GO:0007007;cellular process#GO:0009987;protein insertion into mitochondrial inner membrane#GO:0045039;mitochondrial protein import pathway#GO:7770058;membrane organization#GO:0061024;mitochondrion organization#GO:0007005;intracellular transport#GO:0046907;transport#GO:0006810;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;cellular component organization#GO:0016043;mitochondrial transport#GO:0006839;localization#GO:0051179;cellular localization#GO:0051641 organelle membrane#GO:0031090;inner mitochondrial membrane protein complex#GO:0098800;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;cytoplasm#GO:0005737;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;membrane-bounded organelle#GO:0043227;TIM22 mitochondrial import inner membrane insertion complex#GO:0042721;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;membrane protein complex#GO:0098796;mitochondrion#GO:0005739 HUMAN|HGNC=15527|UniProtKB=Q86Z14 Q86Z14 KLB PTHR10353:SF68 GLYCOSYL HYDROLASE BETA-KLOTHO catalytic activity#GO:0003824;beta-glucosidase activity#GO:0008422;glucosidase activity#GO:0015926;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798 metabolite interconversion enzyme#PC00262;glycosidase#PC00110;hydrolase#PC00121 HUMAN|HGNC=12285|UniProtKB=A0A0A0MS01 A0A0A0MS01 TRGV10 PTHR19256:SF40 T-CELL RECEPTOR GAMMA CHAIN NON-FUNCTIONAL T CELL RECEPTOR GAMMA VARIABLE 10-RELATED immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=24180|UniProtKB=Q8IZ73 Q8IZ73 RPUSD2 PTHR21600:SF40 MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE PSEUDOURIDYLATE SYNTHASE RPUSD2 isomerase activity#GO:0016853;catalytic activity#GO:0003824;intramolecular transferase activity#GO:0016866 macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;rRNA processing#GO:0006364;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;ribosome biogenesis#GO:0042254;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;rRNA modification#GO:0000154;pseudouridine synthesis#GO:0001522;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 RNA processing factor#PC00147 HUMAN|HGNC=5134|UniProtKB=P31277 P31277 HOXD11 PTHR46092:SF2 HOMEOBOX PROTEIN HOX-A11-RELATED HOMEOBOX PROTEIN HOX-D11 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;embryo development#GO:0009790;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;skeletal system morphogenesis#GO:0048705;regulation of gene expression#GO:0010468;multicellular organism development#GO:0007275;embryonic morphogenesis#GO:0048598;regulation of biosynthetic process#GO:0009889;animal organ development#GO:0048513;developmental process#GO:0032502;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;animal organ morphogenesis#GO:0009887;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;skeletal system development#GO:0001501;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;embryonic organ development#GO:0048568;embryo development ending in birth or egg hatching#GO:0009792;chordate embryonic development#GO:0043009;animal gross anatomical part developmental process#GO:0160108 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 homeodomain transcription factor#PC00119 HUMAN|HGNC=14434|UniProtKB=Q96Q40 Q96Q40 CDK15 PTHR24056:SF159 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE 15 protein kinase activity#GO:0004672;protein binding#GO:0005515;phosphotransferase activity, alcohol group as acceptor#GO:0016773;cyclin-dependent protein serine/threonine kinase activity#GO:0004693;protein serine/threonine kinase activity#GO:0004674;cyclin-dependent protein kinase activity#GO:0097472;binding#GO:0005488;catalytic activity, acting on a protein#GO:0140096;cyclin binding#GO:0030332;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;nucleus#GO:0005634;cytosol#GO:0005829;protein kinase complex#GO:1902911;transferase complex#GO:1990234 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=19401|UniProtKB=Q96DM1 Q96DM1 PGBD4 PTHR46599:SF8 PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4 PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4 viral or transposable element protein#PC00237 HUMAN|HGNC=25042|UniProtKB=Q9NT99 Q9NT99 LRRC4B PTHR24369:SF102 ANTIGEN BSP, PUTATIVE-RELATED LEUCINE-RICH REPEAT-CONTAINING PROTEIN 4B cell adhesion mediator activity#GO:0098631;cell adhesion molecule binding#GO:0050839;binding#GO:0005488;cell-cell adhesion mediator activity#GO:0098632;protein binding#GO:0005515 regulation of biological quality#GO:0065008;synaptic membrane adhesion#GO:0099560;regulation of synapse organization#GO:0050807;cell adhesion#GO:0007155;positive regulation of cellular component organization#GO:0051130;regulation of cellular component biogenesis#GO:0044087;positive regulation of nervous system development#GO:0051962;regulation of cellular component organization#GO:0051128;positive regulation of multicellular organismal process#GO:0051240;regulation of organelle organization#GO:0033043;regulation of postsynapse organization#GO:0099175;regulation of multicellular organismal development#GO:2000026;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;cellular component organization or biogenesis#GO:0071840;regulation of multicellular organismal process#GO:0051239;positive regulation of cellular component biogenesis#GO:0044089;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;cell-cell adhesion#GO:0098609;regulation of nervous system development#GO:0051960;regulation of synapse structure or activity#GO:0050803;regulation of cell junction assembly#GO:1901888;synapse organization#GO:0050808;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;cell junction organization#GO:0034330;positive regulation of synapse assembly#GO:0051965;positive regulation of developmental process#GO:0051094;biological regulation#GO:0065007;regulation of synapse assembly#GO:0051963;positive regulation of cellular process#GO:0048522;regulation of organelle assembly#GO:1902115 cellular anatomical structure#GO:0110165;synapse#GO:0045202;asymmetric synapse#GO:0032279;organelle#GO:0043226;postsynapse#GO:0098794;postsynaptic density membrane#GO:0098839;postsynaptic specialization membrane#GO:0099634;postsynaptic membrane#GO:0045211;postsynaptic density#GO:0014069;neuron to neuron synapse#GO:0098984;glutamatergic synapse#GO:0098978;plasma membrane region#GO:0098590;postsynaptic specialization#GO:0099572;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;cell junction#GO:0030054;synaptic membrane#GO:0097060 cell adhesion molecule#PC00069 HUMAN|HGNC=25433|UniProtKB=Q8N468 Q8N468 SLC60A1 PTHR23121:SF10 SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1 SOLUTE CARRIER FAMILY 60 MEMBER 1 transporter#PC00227 HUMAN|HGNC=19599|UniProtKB=Q9H339 Q9H339 OR51B5 PTHR26450:SF76 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 51B5 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=23063|UniProtKB=Q9NV35 Q9NV35 NUDT15 PTHR16099:SF5 8-OXO-DGTP DIPHOSPHATES NUDT15 NUCLEOTIDE TRIPHOSPHATE DIPHOSPHATASE NUDT15 HUMAN|HGNC=10724|UniProtKB=Q13214 Q13214 SEMA3B PTHR11036:SF37 SEMAPHORIN SEMAPHORIN-3B signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;binding#GO:0005488;signaling receptor binding#GO:0005102;molecular function activator activity#GO:0140677;protein binding#GO:0005515 multicellular organismal process#GO:0032501;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;regulation of locomotion#GO:0040012;axon guidance#GO:0007411;axon development#GO:0061564;positive regulation of cellular process#GO:0048522;positive regulation of cell migration#GO:0030335;cellular developmental process#GO:0048869;response to external stimulus#GO:0009605;neuron projection guidance#GO:0097485;positive regulation of locomotion#GO:0040017;neurogenesis#GO:0022008;developmental process#GO:0032502;regulation of cell migration#GO:0030334;neuron projection morphogenesis#GO:0048812;regulation of cellular process#GO:0050794;locomotion#GO:0040011;cellular response to stimulus#GO:0051716;regulation of cell motility#GO:2000145;cell communication#GO:0007154;anatomical structure development#GO:0048856;system development#GO:0048731;chemotaxis#GO:0006935;response to chemical#GO:0042221;taxis#GO:0042330;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;neuron projection development#GO:0031175;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cell projection morphogenesis#GO:0048858;neuron differentiation#GO:0030182;cell surface receptor signaling pathway#GO:0007166;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell differentiation#GO:0030154;response to stimulus#GO:0050896;cell projection organization#GO:0030030;cell morphogenesis#GO:0000902;signaling#GO:0023052;cell development#GO:0048468;positive regulation of cell motility#GO:2000147;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;axonogenesis#GO:0007409;neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 membrane-bound signaling molecule#PC00152 HUMAN|HGNC=11329|UniProtKB=P61278 P61278 SST PTHR10558:SF2 SOMATOSTATIN SOMATOSTATIN receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;molecular function activator activity#GO:0140677;hormone activity#GO:0005179;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546 signal transduction#GO:0007165;cellular process#GO:0009987;response to hormone#GO:0009725;biological regulation#GO:0065007;response to chemical#GO:0042221;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;hormone-mediated signaling pathway#GO:0009755;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to endogenous stimulus#GO:0009719;signaling#GO:0023052;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;regulation of cellular process#GO:0050794;cellular response to hormone stimulus#GO:0032870 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207;peptide hormone#PC00179 HUMAN|HGNC=29859|UniProtKB=Q9P2A4 Q9P2A4 ABI3 PTHR10460:SF7 ABL INTERACTOR FAMILY MEMBER ABI GENE FAMILY MEMBER 3 signaling adaptor activity#GO:0035591;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 cell migration#GO:0016477;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;nervous system development#GO:0007399;regulation of locomotion#GO:0040012;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;neuron migration#GO:0001764;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;cell projection morphogenesis#GO:0048858;neurogenesis#GO:0022008;regulation of cell migration#GO:0030334;developmental process#GO:0032502;cell projection organization#GO:0030030;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;cell motility#GO:0048870;cell morphogenesis#GO:0000902;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;regulation of cell motility#GO:2000145;anatomical structure development#GO:0048856;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699 intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;lamellipodium#GO:0030027;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;actin-based cell projection#GO:0098858;cell leading edge#GO:0031252;actin cytoskeleton#GO:0015629;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 scaffold/adaptor protein#PC00226 HUMAN|HGNC=10436|UniProtKB=P23443 P23443 RPS6KB1 PTHR24351:SF48 RIBOSOMAL PROTEIN S6 KINASE RIBOSOMAL PROTEIN S6 KINASE BETA-1 protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096 cellular response to insulin stimulus#GO:0032869;cellular response to nitrogen compound#GO:1901699;response to chemical#GO:0042221;TOR signaling#GO:0031929;response to peptide hormone#GO:0043434;biological regulation#GO:0065007;response to hormone#GO:0009725;cellular process#GO:0009987;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;TORC1 signaling#GO:0038202;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;response to nitrogen compound#GO:1901698;cellular response to chemical stimulus#GO:0070887;response to oxygen-containing compound#GO:1901700;cellular response to hormone stimulus#GO:0032870;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;cellular response to peptide hormone stimulus#GO:0071375;signaling#GO:0023052;response to endogenous stimulus#GO:0009719;cellular response to stimulus#GO:0051716;response to insulin#GO:0032868;regulation of biological process#GO:0050789 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 protein modifying enzyme#PC00260 PDGF signaling pathway#P00047>p90RSK#P01142;PI3 kinase pathway#P00048>S6K#P01194;CCKR signaling map#P06959>p70S6K1#P07031;p53 pathway by glucose deprivation#P04397>S6K#P04636;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>P90 RSK#P00888 HUMAN|HGNC=2020|UniProtKB=P51788 P51788 CLCN2 PTHR45720:SF6 CHLORIDE CHANNEL PROTEIN 2 CHLORIDE CHANNEL PROTEIN 2 monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;voltage-gated monoatomic anion channel activity#GO:0008308;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic anion transmembrane transporter activity#GO:0008509;passive transmembrane transporter activity#GO:0022803;chloride transmembrane transporter activity#GO:0015108;chloride channel activity#GO:0005254;channel activity#GO:0015267;monoatomic anion channel activity#GO:0005253;voltage-gated channel activity#GO:0022832;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244 transport#GO:0006810;chloride transport#GO:0006821;monoatomic anion transport#GO:0006820;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698;establishment of localization#GO:0051234;localization#GO:0051179 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HUMAN|HGNC=19351|UniProtKB=Q9H694 Q9H694 BICC1 PTHR10627:SF78 SCP160 PROTEIN BICAUDAL C HOMOLOG 1 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HUMAN|HGNC=28242|UniProtKB=Q96IR7 Q96IR7 HPDL PTHR11959:SF10 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE-LIKE PROTEIN catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;dioxygenase activity#GO:0051213;oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen#GO:0016702 oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;proteinogenic amino acid metabolic process#GO:0170039;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;amino acid metabolic process#GO:0006520;small molecule catabolic process#GO:0044282;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 oxygenase#PC00177;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=24098|UniProtKB=O94875 O94875 SORBS2 PTHR14167:SF56 SH3 DOMAIN-CONTAINING SORBIN AND SH3 DOMAIN-CONTAINING PROTEIN 2 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 organelle organization#GO:0006996;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;signaling#GO:0023052;cell surface receptor signaling pathway#GO:0007166;cellular component organization or biogenesis#GO:0071840;cell communication#GO:0007154;Notch signaling pathway#GO:0007219 dendritic tree#GO:0097447;dendrite#GO:0030425;cell junction#GO:0030054;cell periphery#GO:0071944;neuron projection#GO:0043005;cell body#GO:0044297;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;neuronal cell body#GO:0043025;cellular anatomical structure#GO:0110165;synapse#GO:0045202 scaffold/adaptor protein#PC00226 HUMAN|HGNC=16007|UniProtKB=Q969Q1 Q969Q1 TRIM63 PTHR24103:SF570 E3 UBIQUITIN-PROTEIN LIGASE TRIM E3 UBIQUITIN-PROTEIN LIGASE TRIM63 ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740 response to external stimulus#GO:0009605;defense response#GO:0006952;innate immune response#GO:0045087;immune system process#GO:0002376;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to other organism#GO:0051707;response to stimulus#GO:0050896;defense response to other organism#GO:0098542;defense response to symbiont#GO:0140546;immune response#GO:0006955;response to biotic stimulus#GO:0009607;response to stress#GO:0006950 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=1164|UniProtKB=P61165 P61165 TMEM258 PTHR13636:SF0 TRANSMEMBRANE PROTEIN 258 DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT TMEM258 binding#GO:0005488;protein-containing complex binding#GO:0044877 response to stimulus#GO:0050896;response to endoplasmic reticulum stress#GO:0034976;response to stress#GO:0006950;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cellular response to stress#GO:0033554 membrane#GO:0016020;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endoplasmic reticulum membrane#GO:0005789;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090 HUMAN|HGNC=26924|UniProtKB=Q6P2C0 Q6P2C0 WDR93 PTHR12219:SF17 NADH-UBIQUINONE OXIDOREDUCTASE WD REPEAT-CONTAINING PROTEIN 93 metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091;cellular component organization or biogenesis#GO:0071840;energy derivation by oxidation of organic compounds#GO:0015980;NADH dehydrogenase complex assembly#GO:0010257;protein-containing complex organization#GO:0043933;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;electron transport chain#GO:0022900;cellular process#GO:0009987;respiratory electron transport chain#GO:0022904;cellular component assembly#GO:0022607;mitochondrion organization#GO:0007005;mitochondrial respiratory chain complex assembly#GO:0033108;cellular respiration#GO:0045333;mitochondrial respiratory chain complex I assembly#GO:0032981;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003 protein-containing complex#GO:0032991;cytoplasm#GO:0005737;oxidoreductase complex#GO:1990204;membrane#GO:0016020;respiratory chain complex#GO:0098803;transporter complex#GO:1990351;respiratory chain complex I#GO:0045271;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;mitochondrion#GO:0005739;transmembrane transporter complex#GO:1902495;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;catalytic complex#GO:1902494 oxidoreductase#PC00176 HUMAN|HGNC=33433|UniProtKB=Q6IMI4 Q6IMI4 SULT6B1 PTHR11783:SF55 SULFOTRANSFERASE SULT SULFOTRANSFERASE 6B1 sulfotransferase activity#GO:0008146;transferase activity, transferring sulphur-containing groups#GO:0016782;catalytic activity#GO:0003824;transferase activity#GO:0016740 cellular process#GO:0009987;metabolic process#GO:0008152;sulfur compound metabolic process#GO:0006790 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;transferase#PC00220 HUMAN|HGNC=24751|UniProtKB=Q3KQV3 Q3KQV3 ZNF792 PTHR24377:SF662 IP01015P-RELATED ZINC FINGER PROTEIN 792 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=28704|UniProtKB=Q7Z2Z1 Q7Z2Z1 TICRR PTHR21556:SF2 TRESLIN TRESLIN binding#GO:0005488;chromatin binding#GO:0003682 response to stress#GO:0006950;cellular process#GO:0009987;signal transduction#GO:0007165;negative regulation of G2/M transition of mitotic cell cycle#GO:0010972;negative regulation of mitotic cell cycle phase transition#GO:1901991;cell cycle checkpoint signaling#GO:0000075;regulation of DNA-templated DNA replication initiation#GO:0030174;regulation of cell cycle process#GO:0010564;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;negative regulation of cell cycle#GO:0045786;DNA replication checkpoint signaling#GO:0000076;negative regulation of cell cycle G2/M phase transition#GO:1902750;negative regulation of cell cycle phase transition#GO:1901988;negative regulation of biological process#GO:0048519;regulation of DNA metabolic process#GO:0051052;cell cycle process#GO:0022402;mitotic DNA replication checkpoint signaling#GO:0033314;regulation of biological process#GO:0050789;signal transduction in response to DNA damage#GO:0042770;response to stimulus#GO:0050896;signaling#GO:0023052;regulation of cell cycle#GO:0051726;cellular response to stress#GO:0033554;regulation of DNA replication#GO:0006275;regulation of mitotic cell cycle phase transition#GO:1901990;mitotic G2 DNA damage checkpoint signaling#GO:0007095;negative regulation of mitotic cell cycle#GO:0045930;regulation of metabolic process#GO:0019222;DNA integrity checkpoint signaling#GO:0031570;regulation of cell cycle G2/M phase transition#GO:1902749;regulation of primary metabolic process#GO:0080090;regulation of mitotic cell cycle#GO:0007346;mitotic DNA integrity checkpoint signaling#GO:0044774;mitotic G2/M transition checkpoint#GO:0044818;DNA damage checkpoint signaling#GO:0000077;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of cellular process#GO:0048523;negative regulation of cell cycle process#GO:0010948;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;mitotic cell cycle process#GO:1903047;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of cell cycle phase transition#GO:1901987;cell cycle#GO:0007049;mitotic cell cycle checkpoint signaling#GO:0007093;cellular response to stimulus#GO:0051716;DNA replication#GO:0006260;mitotic DNA damage checkpoint signaling#GO:0044773;regulation of DNA-templated DNA replication#GO:0090329;regulation of cellular process#GO:0050794;mitotic cell cycle#GO:0000278;regulation of macromolecule metabolic process#GO:0060255;cell communication#GO:0007154;regulation of G2/M transition of mitotic cell cycle#GO:0010389;intracellular signal transduction#GO:0035556 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=21212|UniProtKB=Q8N7X0 Q8N7X0 ADGB PTHR46298:SF1 ANDROGLOBIN ANDROGLOBIN sperm flagellum#GO:0036126;cellular anatomical structure#GO:0110165;motile cilium#GO:0031514;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cilium#GO:0005929;9+2 motile cilium#GO:0097729;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=26526|UniProtKB=Q96MA6 Q96MA6 AK8 PTHR23359:SF271 NUCLEOTIDE KINASE ADENYLATE KINASE 8 phosphotransferase activity, phosphate group as acceptor#GO:0016776;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;nucleobase-containing compound kinase activity#GO:0019205;transferase activity#GO:0016740 phosphorus metabolic process#GO:0006793;purine nucleotide metabolic process#GO:0006163;ribonucleoside diphosphate metabolic process#GO:0009185;purine-containing compound metabolic process#GO:0072521;small molecule metabolic process#GO:0044281;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;ribonucleotide metabolic process#GO:0009259;purine nucleoside diphosphate metabolic process#GO:0009135;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;nucleotide biosynthetic process#GO:0009165;ribose phosphate biosynthetic process#GO:0046390;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing compound biosynthetic process#GO:0034654;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;primary metabolic process#GO:0044238;nucleoside phosphate metabolic process#GO:0006753;nucleoside diphosphate metabolic process#GO:0009132;organophosphate biosynthetic process#GO:0090407;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;carbohydrate derivative metabolic process#GO:1901135;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;purine ribonucleoside diphosphate metabolic process#GO:0009179;nucleoside phosphate biosynthetic process#GO:1901293;ADP metabolic process#GO:0046031 mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 nucleotide kinase#PC00172;kinase#PC00137 Salvage pyrimidine ribonucleotides#P02775>Cytidylate kinase#P03153;De novo purine biosynthesis#P02738>Adenylate kinase#P02896 HUMAN|HGNC=10469|UniProtKB=O95197 O95197 RTN3 PTHR45799:SF4 RETICULON-LIKE PROTEIN RETICULON-3 endoplasmic reticulum membrane organization#GO:0090158;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;endoplasmic reticulum organization#GO:0007029;organelle organization#GO:0006996;cellular component organization#GO:0016043;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;endoplasmic reticulum tubular network organization#GO:0071786 endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=20201|UniProtKB=Q9NWN3 Q9NWN3 FBXO34 PTHR16271:SF11 F-BOX ONLY PROTEIN 34/46 FAMILY MEMBER F-BOX ONLY PROTEIN 34 HUMAN|HGNC=14725|UniProtKB=Q6IF00 Q6IF00 OR2T2 PTHR26453:SF18 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2T2-RELATED transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 system process#GO:0003008;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;nervous system process#GO:0050877;sensory perception#GO:0007600;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;response to chemical#GO:0042221;response to stimulus#GO:0050896;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;detection of chemical stimulus#GO:0009593 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|Ensembl=ENSG00000283763.3|UniProtKB=A0A1W2PQF6 A0A1W2PQF6 PTHR11738:SF168 MHC CLASS I NK CELL RECEPTOR IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN-RELATED transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;immune receptor activity#GO:0140375 regulation of immune response#GO:0050776;cell surface receptor signaling pathway#GO:0007166;regulation of response to stimulus#GO:0048583;cell communication#GO:0007154;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;immune response-regulating signaling pathway#GO:0002764;cellular response to stimulus#GO:0051716;signaling#GO:0023052;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=29606|UniProtKB=Q8N8V2 Q8N8V2 GBP7 PTHR10751:SF138 GUANYLATE BINDING PROTEIN GUANYLATE-BINDING PROTEIN 7 catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229 heterotrimeric G-protein#PC00117;G-protein#PC00020 HUMAN|HGNC=1758|UniProtKB=Q9H159 Q9H159 CDH19 PTHR24027:SF323 CADHERIN-23 CADHERIN-19 cell adhesion molecule binding#GO:0050839;binding#GO:0005488;beta-catenin binding#GO:0008013;protein binding#GO:0005515 cellular process#GO:0009987;cell-cell adhesion#GO:0098609;cellular component biogenesis#GO:0044085;cell migration#GO:0016477;cellular component assembly#GO:0022607;cell-cell junction assembly#GO:0007043;cell-cell junction organization#GO:0045216;developmental process#GO:0032502;cellular component organization or biogenesis#GO:0071840;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;cell junction assembly#GO:0034329;adherens junction organization#GO:0034332;cell morphogenesis#GO:0000902;cell motility#GO:0048870;cell junction organization#GO:0034330;cell adhesion#GO:0007155;anatomical structure development#GO:0048856 membrane protein complex#GO:0098796;membrane#GO:0016020;cell-cell junction#GO:0005911;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cell junction#GO:0030054;extrinsic component of membrane#GO:0019898;extrinsic component of plasma membrane#GO:0019897;adherens junction#GO:0005912;anchoring junction#GO:0070161 cadherin#PC00057;cell adhesion molecule#PC00069 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HUMAN|HGNC=5427|UniProtKB=P05013 P05013 IFNA6 PTHR11691:SF27 TYPE I INTERFERON INTERFERON ALPHA-6 cytokine receptor binding#GO:0005126;binding#GO:0005488;signaling receptor binding#GO:0005102;cytokine activity#GO:0005125;protein-containing complex binding#GO:0044877;molecular function activator activity#GO:0140677;protein binding#GO:0005515;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546 immune response#GO:0006955;biological regulation#GO:0065007;response to other organism#GO:0051707;adaptive immune response#GO:0002250;multicellular organismal process#GO:0032501;response to external stimulus#GO:0009605;defense response#GO:0006952;innate immune response#GO:0045087;cellular response to stimulus#GO:0051716;leukocyte activation#GO:0045321;response to external biotic stimulus#GO:0043207;regulation of cellular process#GO:0050794;cell activation#GO:0001775;cytokine-mediated signaling pathway#GO:0019221;response to nitrogen compound#GO:1901698;cell communication#GO:0007154;lymphocyte activation involved in immune response#GO:0002285;signal transduction#GO:0007165;defense response to symbiont#GO:0140546;cellular process#GO:0009987;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;T cell activation involved in immune response#GO:0002286;lymphocyte activation#GO:0046649;response to chemical#GO:0042221;response to cytokine#GO:0034097;defense response to other organism#GO:0098542;immune effector process#GO:0002252;cell surface receptor signaling pathway#GO:0007166;natural killer cell activation#GO:0030101;leukocyte activation involved in immune response#GO:0002366;humoral immune response#GO:0006959;B cell activation#GO:0042113;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;T cell activation#GO:0042110;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;immune system process#GO:0002376;type I interferon-mediated signaling pathway#GO:0060337;B cell activation involved in immune response#GO:0002312;response to peptide#GO:1901652;cell activation involved in immune response#GO:0002263 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 cytokine#PC00083;interferon superfamily#PC00127 HUMAN|HGNC=11100|UniProtKB=P51532 P51532 SMARCA4 PTHR10799:SF76 SNF2/RAD54 HELICASE FAMILY SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 4 catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on DNA#GO:0140097;binding#GO:0005488;nucleic acid binding#GO:0003676;chromatin binding#GO:0003682;ATP-dependent activity#GO:0140657;DNA binding#GO:0003677;ATP-dependent activity, acting on DNA#GO:0008094 regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;heterochromatin formation#GO:0031507;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;chromatin organization#GO:0006325;negative regulation of biosynthetic process#GO:0009890;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of transcription by RNA polymerase II#GO:0006357;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of gene expression, epigenetic#GO:0045814;cellular component organization or biogenesis#GO:0071840;positive regulation of transcription by RNA polymerase II#GO:0045944;cellular component assembly#GO:0022607;positive regulation of macromolecule metabolic process#GO:0010604;heterochromatin organization#GO:0070828;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;positive regulation of biological process#GO:0048518 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694;nucleus#GO:0005634;chromatin#GO:0000785 DNA helicase#PC00011;DNA metabolism protein#PC00009 Wnt signaling pathway#P00057>SWI/SNF#P01435 HUMAN|HGNC=53440|UniProtKB=A0A1B0GV90 A0A1B0GV90 CTXND2 PTHR16736:SF6 CORTEXIN-1-RELATED CORTEXIN DOMAIN CONTAINING 2 HUMAN|HGNC=33773|UniProtKB=Q6UWF9 Q6UWF9 FAM180A PTHR34034:SF2 PROTEIN FAM180A-RELATED PROTEIN FAM180A HUMAN|HGNC=13572|UniProtKB=Q9Y6R7 Q9Y6R7 FCGBP PTHR11339:SF373 EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED IGGFC-BINDING PROTEIN extracellular matrix structural constituent#GO:0005201;structural molecule activity#GO:0005198 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012 extracellular matrix protein#PC00102 HUMAN|HGNC=19214|UniProtKB=Q8TBC3 Q8TBC3 SHKBP1 PTHR15859:SF5 SETA BINDING PROTEIN 1 SH3KBP1-BINDING PROTEIN 1 positive regulation of signaling#GO:0023056;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;positive regulation of response to stimulus#GO:0048584;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;regulation of epidermal growth factor receptor signaling pathway#GO:0042058;positive regulation of signal transduction#GO:0009967;positive regulation of biological process#GO:0048518;regulation of ERBB signaling pathway#GO:1901184;regulation of biological process#GO:0050789;positive regulation of cellular process#GO:0048522 scaffold/adaptor protein#PC00226 HUMAN|HGNC=15805|UniProtKB=Q96QF7 Q96QF7 GCNA PTHR23099:SF0 TRANSCRIPTIONAL REGULATOR GERM CELL NUCLEAR ACIDIC PROTEIN intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HMG box transcription factor#PC00024 HUMAN|HGNC=19020|UniProtKB=Q96LD4 Q96LD4 TRIM47 PTHR25465:SF21 B-BOX DOMAIN CONTAINING E3 UBIQUITIN-PROTEIN LIGASE TRIM47 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=1622|UniProtKB=Q99832 Q99832 CCT7 PTHR11353:SF22 CHAPERONIN T-COMPLEX PROTEIN 1 SUBUNIT ETA protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;protein folding#GO:0006457;biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238 cytosol#GO:0005829;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;protein folding chaperone complex#GO:0101031;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;chaperonin-containing T-complex#GO:0005832 chaperonin#PC00073 HUMAN|HGNC=30791|UniProtKB=Q9Y5Z9 Q9Y5Z9 UBIAD1 PTHR13929:SF17 1,4-DIHYDROXY-2-NAPHTHOATE OCTAPRENYLTRANSFERASE UBIA PRENYLTRANSFERASE DOMAIN-CONTAINING PROTEIN 1 transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;prenyltransferase activity#GO:0004659;transferase activity#GO:0016740;catalytic activity#GO:0003824 ketone metabolic process#GO:0042180;vitamin K metabolic process#GO:0042373;ketone biosynthetic process#GO:0042181;cellular process#GO:0009987;small molecule metabolic process#GO:0044281;menaquinone biosynthetic process#GO:0009234;biosynthetic process#GO:0009058;metabolic process#GO:0008152;small molecule biosynthetic process#GO:0044283 transferase#PC00220 HUMAN|HGNC=24587|UniProtKB=Q9BYI3 Q9BYI3 HYCC1 PTHR31220:SF4 HYCCIN RELATED HYCCIN phospholipid metabolic process#GO:0006644;glycerolipid metabolic process#GO:0046486;phospholipid biosynthetic process#GO:0008654;protein localization to membrane#GO:0072657;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;protein localization to plasma membrane#GO:0072659;localization#GO:0051179;cellular localization#GO:0051641;organophosphate biosynthetic process#GO:0090407;localization within membrane#GO:0051668;phosphatidylinositol phosphate biosynthetic process#GO:0046854;biosynthetic process#GO:0009058;glycerophospholipid metabolic process#GO:0006650;lipid biosynthetic process#GO:0008610;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;organophosphate metabolic process#GO:0019637;macromolecule localization#GO:0033036;intracellular protein localization#GO:0008104;glycerophospholipid biosynthetic process#GO:0046474;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;protein localization to cell periphery#GO:1990778 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=6460|UniProtKB=P78385 P78385 KRT83 PTHR45616:SF52 GATA-TYPE DOMAIN-CONTAINING PROTEIN KERATIN, TYPE II CUTICULAR HB3 structural molecule activity#GO:0005198 animal organ development#GO:0048513;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;developmental process#GO:0032502;epidermis development#GO:0008544;skin development#GO:0043588;cytoskeleton organization#GO:0007010;epidermal cell differentiation#GO:0009913;tissue development#GO:0009888;epithelial cell differentiation#GO:0030855;multicellular organismal process#GO:0032501;epithelium development#GO:0060429;cellular process#GO:0009987;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;anatomical structure development#GO:0048856;intermediate filament organization#GO:0045109;keratinocyte differentiation#GO:0030216;animal gross anatomical part developmental process#GO:0160108;intermediate filament-based process#GO:0045103;intermediate filament cytoskeleton organization#GO:0045104;cell differentiation#GO:0030154;cellular component organization#GO:0016043 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intermediate filament#GO:0005882;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;intracellular membraneless organelle#GO:0043232;supramolecular complex#GO:0099080;organelle#GO:0043226;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081 HUMAN|HGNC=12790|UniProtKB=O00258 O00258 GET1 PTHR42650:SF1 TAIL-ANCHORED PROTEIN INSERTION RECEPTOR WRB GUIDED ENTRY OF TAIL-ANCHORED PROTEINS FACTOR 1 protein-membrane adaptor activity#GO:0043495;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 cellular localization#GO:0051641;localization#GO:0051179;localization within membrane#GO:0051668;protein localization to organelle#GO:0033365;cellular component organization#GO:0016043;protein insertion into ER membrane#GO:0045048;endoplasmic reticulum organization#GO:0007029;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;intracellular protein localization#GO:0008104;protein insertion into membrane#GO:0051205;tail-anchored membrane protein insertion into ER membrane#GO:0071816;membrane organization#GO:0061024;endomembrane system organization#GO:0010256;establishment of protein localization to membrane#GO:0090150;macromolecule localization#GO:0033036;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of protein localization#GO:0045184 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;endoplasmic reticulum protein-containing complex#GO:0140534;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=9852|UniProtKB=O95373 O95373 IPO7 PTHR10997:SF27 IMPORTIN-7, 8, 11 IMPORTIN-7 nucleocytoplasmic carrier activity#GO:0140142;molecular carrier activity#GO:0140104 cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;protein localization to nucleus#GO:0034504;macromolecule localization#GO:0033036;import into nucleus#GO:0051170;transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;protein localization to organelle#GO:0033365;nucleocytoplasmic transport#GO:0006913;protein transport#GO:0015031;protein import into nucleus#GO:0006606;nuclear transport#GO:0051169;cellular localization#GO:0051641;localization#GO:0051179 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cytosol#GO:0005829;organelle envelope#GO:0031967;nucleus#GO:0005634 transporter#PC00227 HUMAN|HGNC=15431|UniProtKB=Q9NZP5 Q9NZP5 OR5AC2 PTHR26452:SF812 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5AC2 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 system process#GO:0003008;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;sensory perception#GO:0007600;nervous system process#GO:0050877;sensory perception of chemical stimulus#GO:0007606 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=33551|UniProtKB=A1L188 A1L188 NDUFAF8 PTHR34561:SF1 NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 8 NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 8 cellular component assembly#GO:0022607;mitochondrion organization#GO:0007005;mitochondrial respiratory chain complex assembly#GO:0033108;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular component organization#GO:0016043;mitochondrial respiratory chain complex I assembly#GO:0032981;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;NADH dehydrogenase complex assembly#GO:0010257 mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HUMAN|HGNC=9537|UniProtKB=P20618 P20618 PSMB1 PTHR32194:SF2 METALLOPROTEASE TLDD PROTEASOME SUBUNIT BETA TYPE-1 protein catabolic process#GO:0030163;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;cellular process#GO:0009987;primary metabolic process#GO:0044238;catabolic process#GO:0009056 peptidase complex#GO:1905368;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;proteasome complex#GO:0000502;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;endopeptidase complex#GO:1905369;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 metalloprotease#PC00153 Parkinson disease#P00049>20S proteasome#P01227 HUMAN|HGNC=26177|UniProtKB=Q6UXD7 Q6UXD7 SLC49A3 PTHR10924:SF6 MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED SOLUTE CARRIER FAMILY 49 MEMBER A3 cellular anatomical structure#GO:0110165;membrane#GO:0016020 secondary carrier transporter#PC00258 HUMAN|HGNC=30465|UniProtKB=Q6PCB8 Q6PCB8 EMB PTHR10075:SF4 BASIGIN RELATED EMBIGIN cell adhesion molecule#PC00069 HUMAN|HGNC=19360|UniProtKB=Q53G59 Q53G59 KLHL12 PTHR24412:SF455 KELCH PROTEIN KELCH-LIKE PROTEIN 12 ubiquitin-like ligase-substrate adaptor activity#GO:1990756;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;enzyme-substrate adaptor activity#GO:0140767 proteasomal protein catabolic process#GO:0010498;vesicle-mediated transport#GO:0016192;cellular component assembly#GO:0022607;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;vesicle organization#GO:0016050;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;Golgi vesicle transport#GO:0048193;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;cellular localization#GO:0051641;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;membrane organization#GO:0061024;ubiquitin-dependent protein catabolic process#GO:0006511;vesicle budding from membrane#GO:0006900;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;transport#GO:0006810;intracellular transport#GO:0046907;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;catabolic process#GO:0009056;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;protein metabolic process#GO:0019538;localization#GO:0051179;COPII-coated vesicle budding#GO:0090114 protein-containing complex#GO:0032991;cytoplasm#GO:0005737;Cul3-RING ubiquitin ligase complex#GO:0031463;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;COPII-coated ER to Golgi transport vesicle#GO:0030134;ubiquitin ligase complex#GO:0000151;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;coated vesicle#GO:0030135;intracellular organelle#GO:0043229;catalytic complex#GO:1902494 scaffold/adaptor protein#PC00226 HUMAN|HGNC=11219|UniProtKB=P09486 P09486 SPARC PTHR13866:SF6 SPARC OSTEONECTIN SPARC cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167 embryonic organ development#GO:0048568;regulation of synapse organization#GO:0050807;animal gross anatomical part developmental process#GO:0160108;regulation of biological quality#GO:0065008;ear development#GO:0043583;regulation of synapse structure or activity#GO:0050803;anatomical structure development#GO:0048856;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;tube morphogenesis#GO:0035239;regulation of cellular component organization#GO:0051128;animal organ morphogenesis#GO:0009887;regulation of cellular process#GO:0050794;sensory organ morphogenesis#GO:0090596;developmental process#GO:0032502;sensory organ development#GO:0007423;multicellular organism development#GO:0007275;embryonic morphogenesis#GO:0048598;animal organ development#GO:0048513;inner ear morphogenesis#GO:0042472;inner ear development#GO:0048839;biological regulation#GO:0065007;embryo development#GO:0009790;tube development#GO:0035295;multicellular organismal process#GO:0032501 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 extracellular matrix protein#PC00102;extracellular matrix glycoprotein#PC00100 HUMAN|HGNC=29878|UniProtKB=Q9NQR4 Q9NQR4 NIT2 PTHR23088:SF30 NITRILASE-RELATED OMEGA-AMIDASE NIT2 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;catalytic activity#GO:0003824;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity#GO:0016787 small molecule metabolic process#GO:0044281;cellular process#GO:0009987;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;carboxylic acid metabolic process#GO:0019752 hydrolase#PC00121 HUMAN|Ensembl=ENSG00000206356.6|UniProtKB=A0ABB0MVE8 A0ABB0MVE8 PTHR15566:SF11 POM121-LIKE SUBFAMILY NOT NAMED HUMAN|HGNC=32594|UniProtKB=Q8TCU6 Q8TCU6 PREX1 PTHR22829:SF6 DEP DOMAIN PROTEIN PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE-DEPENDENT RAC EXCHANGER 1 PROTEIN molecular function activator activity#GO:0140677;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;guanyl-nucleotide exchange factor activity#GO:0005085;protein kinase inhibitor activity#GO:0004860;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;protein kinase regulator activity#GO:0019887;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;kinase inhibitor activity#GO:0019210;enzyme inhibitor activity#GO:0004857;enzyme activator activity#GO:0008047 negative regulation of TOR signaling#GO:0032007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of cell communication#GO:0010646;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;negative regulation of signaling#GO:0023057;G protein-coupled receptor signaling pathway#GO:0007186;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;negative regulation of response to stimulus#GO:0048585;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of TOR signaling#GO:0032006;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 protein-binding activity modulator#PC00095;G-protein modulator#PC00022;guanyl-nucleotide exchange factor#PC00113 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>GEF#P00875 HUMAN|HGNC=21072|UniProtKB=Q5SRI9 Q5SRI9 MANEA PTHR13572:SF1 ENDO-ALPHA-1,2-MANNOSIDASE GLYCOPROTEIN ENDO-ALPHA-1,2-MANNOSIDASE hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;membrane#GO:0016020;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139 HUMAN|HGNC=20709|UniProtKB=Q9NWH9 Q9NWH9 SLTM PTHR15683:SF5 SCAFFOLD ATTACHMENT FACTOR B-RELATED SAFB-LIKE TRANSCRIPTION MODULATOR cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=26210|UniProtKB=Q32M88 Q32M88 PGGHG PTHR11051:SF17 GLYCOSYL HYDROLASE-RELATED PROTEIN-GLUCOSYLGALACTOSYLHYDROXYLYSINE GLUCOSIDASE catalytic activity, acting on a protein#GO:0140096;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824;glucosidase activity#GO:0015926 carbohydrate metabolic process#GO:0005975;primary metabolic process#GO:0044238;metabolic process#GO:0008152;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 glycosidase#PC00110;hydrolase#PC00121 HUMAN|HGNC=9055|UniProtKB=Q00722 Q00722 PLCB2 PTHR10336:SF10 PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN 1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2 phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578;catalytic activity#GO:0003824;glycerophospholipase activity#GO:0004620;phospholipase activity#GO:0120569;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;lipase activity#GO:0016298 biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;organophosphate metabolic process#GO:0019637;establishment of localization#GO:0051234;lipid metabolic process#GO:0006629;transport#GO:0006810;phosphatidylinositol metabolic process#GO:0046488;regulation of cellular process#GO:0050794;metal ion transport#GO:0030001;phospholipid metabolic process#GO:0006644;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;localization#GO:0051179;monoatomic cation transport#GO:0006812;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;glycerophospholipid metabolic process#GO:0006650;monoatomic cation transmembrane transport#GO:0098655;signal transduction#GO:0007165;release of sequestered calcium ion into cytosol#GO:0051209;cellular process#GO:0009987;calcium ion transmembrane import into cytosol#GO:0097553;calcium ion transport#GO:0006816;metabolic process#GO:0008152;response to stimulus#GO:0050896;glycerolipid metabolic process#GO:0046486;signaling#GO:0023052;calcium ion transmembrane transport#GO:0070588;phosphorus metabolic process#GO:0006793;regulation of biological process#GO:0050789;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;G protein-coupled receptor signaling pathway#GO:0007186 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 hydrolase#PC00121;lipase#PC00143;phospholipase#PC00186;metabolite interconversion enzyme#PC00262 Thyrotropin-releasing hormone receptor signaling pathway#P04394>PLC#P04581;Alpha adrenergic receptor signaling pathway#P00002>PLC#P00073;2-arachidonoylglycerol biosynthesis#P05726>PLC#P05738;Oxytocin receptor mediated signaling pathway#P04391>PLC beta#P04530;Wnt signaling pathway#P00057>Phospholipase C#P01443;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PLCbetagamma#P00874;Angiotensin II-stimulated signaling through G proteins and beta-arrestin#P05911>PLC#P05933;5HT2 type receptor mediated signaling pathway#P04374>PLC#P04412;Endogenous cannabinoid signaling#P05730>PLC#P05746;Histamine H1 receptor mediated signaling pathway#P04385>PLC#P04484;Endothelin signaling pathway#P00019>PLCbeta#P00591;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Phospholipase C-beta#P00744 HUMAN|HGNC=12541|UniProtKB=O60656 O60656 UGT1A9 PTHR48050:SF6 STEROL 3-BETA-GLUCOSYLTRANSFERASE UDP-GLUCURONOSYLTRANSFERASE 1A10-RELATED binding#GO:0005488;enzyme binding#GO:0019899;enzyme regulator activity#GO:0030234;protein binding#GO:0005515;molecular function inhibitor activity#GO:0140678;catalytic activity#GO:0003824;transferase activity#GO:0016740;enzyme inhibitor activity#GO:0004857;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;molecular function regulator activity#GO:0098772 multicellular organism development#GO:0007275;cellular response to steroid hormone stimulus#GO:0071383;animal organ development#GO:0048513;metabolic process#GO:0008152;response to chemical#GO:0042221;response to lipid#GO:0033993;cellular response to lipid#GO:0071396;steroid metabolic process#GO:0008202;response to hormone#GO:0009725;cellular process#GO:0009987;estrogen metabolic process#GO:0008210;regulation of biological quality#GO:0065008;cellular response to chemical stimulus#GO:0070887;animal gross anatomical part developmental process#GO:0160108;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;liver development#GO:0001889;cellular response to hormone stimulus#GO:0032870;response to endogenous stimulus#GO:0009719;regulation of hormone levels#GO:0010817;sterol metabolic process#GO:0016125;developmental process#GO:0032502;lipid metabolic process#GO:0006629;hormone metabolic process#GO:0042445;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;pigment metabolic process#GO:0042440;anatomical structure development#GO:0048856;system development#GO:0048731;response to steroid hormone#GO:0048545;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 transferase#PC00220;glycosyltransferase#PC00111 HUMAN|HGNC=28990|UniProtKB=Q92618 Q92618 ZNF516 PTHR45925:SF3 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 516 nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=24577|UniProtKB=Q6ICB0 Q6ICB0 DESI1 PTHR12378:SF7 DESUMOYLATING ISOPEPTIDASE DESUMOYLATING ISOPEPTIDASE 1 establishment of localization#GO:0051234;regulation of catabolic process#GO:0009894;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;transport#GO:0006810;intracellular protein transport#GO:0006886;regulation of proteasomal protein catabolic process#GO:0061136;protein export from nucleus#GO:0006611;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;regulation of primary metabolic process#GO:0080090;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular localization#GO:0051641;localization#GO:0051179;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434;nuclear export#GO:0051168;regulation of protein catabolic process#GO:0042176;protein transport#GO:0015031;nuclear transport#GO:0051169;nucleocytoplasmic transport#GO:0006913;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789 cysteine protease#PC00081;protease#PC00190 HUMAN|HGNC=20989|UniProtKB=Q96T66 Q96T66 NMNAT3 PTHR12039:SF7 NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE NICOTINAMIDE_NICOTINIC ACID MONONUCLEOTIDE ADENYLYLTRANSFERASE 3 nucleotidyltransferase activity#GO:0016779;catalytic activity#GO:0003824;transferase activity#GO:0016740;adenylyltransferase activity#GO:0070566;transferase activity, transferring phosphorus-containing groups#GO:0016772 nucleotide biosynthetic process#GO:0009165;nucleotide metabolic process#GO:0009117;organophosphate biosynthetic process#GO:0090407;pyridine-containing compound metabolic process#GO:0072524;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;nucleobase-containing small molecule metabolic process#GO:0055086;nucleoside phosphate biosynthetic process#GO:1901293;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;nicotinamide nucleotide metabolic process#GO:0046496;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;NAD+ metabolic process#GO:0019674 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739 nucleotidyltransferase#PC00174;transferase#PC00220 HUMAN|HGNC=31909|UniProtKB=P43362 P43362 MAGEA9 PTHR11736:SF62 MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN MELANOMA-ASSOCIATED ANTIGEN 9 binding#GO:0005488;enzyme binding#GO:0019899;protein binding#GO:0005515;histone deacetylase binding#GO:0042826 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 scaffold/adaptor protein#PC00226 HUMAN|HGNC=28472|UniProtKB=Q9BTV4 Q9BTV4 TMEM43 PTHR13416:SF2 FAMILY NOT NAMED TRANSMEMBRANE PROTEIN 43 cellular process#GO:0009987;lipid metabolic process#GO:0006629;primary metabolic process#GO:0044238;metabolic process#GO:0008152 HUMAN|HGNC=25928|UniProtKB=Q6P4I2 Q6P4I2 WDR73 PTHR46947:SF1 WD REPEAT-CONTAINING PROTEIN 73 INTEGRATOR COMPLEX ASSEMBLY FACTOR WDR73 cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;cytoskeleton organization#GO:0007010;cytoplasmic microtubule organization#GO:0031122;supramolecular fiber organization#GO:0097435;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630;cytosol#GO:0005829;spindle pole#GO:0000922;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;spindle#GO:0005819;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 HUMAN|HGNC=13680|UniProtKB=Q96JB8 Q96JB8 MPP4 PTHR23122:SF34 MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK MAGUK P55 SUBFAMILY MEMBER 4 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;cell-cell junction#GO:0005911;membrane#GO:0016020;anchoring junction#GO:0070161;adherens junction#GO:0005912;cell junction#GO:0030054 scaffold/adaptor protein#PC00226 HUMAN|HGNC=41525|UniProtKB=P61550 P61550 ERVS71-1 PTHR10424:SF75 VIRAL ENVELOPE PROTEIN ENDOGENOUS RETROVIRUS GROUP S71 MEMBER 1 ENV POLYPROTEIN-RELATED developmental process#GO:0032502;cell-cell fusion#GO:0140253;animal gross anatomical part developmental process#GO:0160108;striated muscle cell differentiation#GO:0051146;syncytium formation by cell-cell fusion#GO:0000768;cellular developmental process#GO:0048869;anatomical structure development#GO:0048856;muscle cell differentiation#GO:0042692;cellular process#GO:0009987;myoblast fusion#GO:0007520;cell differentiation#GO:0030154;muscle structure development#GO:0061061 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 viral or transposable element protein#PC00237 HUMAN|HGNC=29122|UniProtKB=Q8N3P4 Q8N3P4 VPS8 PTHR12616:SF16 VACUOLAR PROTEIN SORTING VPS41 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 8 HOMOLOG molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;protein-membrane adaptor activity#GO:0043495 cellular component organization#GO:0016043;membrane fusion#GO:0061025;organelle organization#GO:0006996;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;organelle fusion#GO:0048284;organelle membrane fusion#GO:0090174;membrane organization#GO:0061024;vesicle fusion#GO:0006906;transport#GO:0006810;establishment of localization#GO:0051234;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;vesicle organization#GO:0016050 intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;early endosome#GO:0005769;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;vesicle tethering complex#GO:0099023;endomembrane system#GO:0012505;late endosome#GO:0005770;protein-containing complex#GO:0032991;cytoplasm#GO:0005737 membrane traffic protein#PC00150 HUMAN|HGNC=11941|UniProtKB=O95271 O95271 TNKS PTHR24180:SF3 CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED POLY [ADP-RIBOSE] POLYMERASE TANKYRASE-1 pentosyltransferase activity#GO:0016763;transferase activity#GO:0016740;catalytic activity#GO:0003824;NAD+ poly-ADP-ribosyltransferase activity#GO:0003950;glycosyltransferase activity#GO:0016757 regulation of signaling#GO:0023051;positive regulation of cellular component organization#GO:0051130;positive regulation of organelle organization#GO:0010638;positive regulation of signaling#GO:0023056;positive regulation of metabolic process#GO:0009893;regulation of DNA metabolic process#GO:0051052;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of cellular component organization#GO:0051128;regulation of Wnt signaling pathway#GO:0030111;regulation of canonical Wnt signaling pathway#GO:0060828;positive regulation of biological process#GO:0048518;positive regulation of Wnt signaling pathway#GO:0030177;positive regulation of macromolecule metabolic process#GO:0010604;localization#GO:0051179;positive regulation of DNA metabolic process#GO:0051054;positive regulation of signal transduction#GO:0009967;regulation of cellular process#GO:0050794;protein localization to organelle#GO:0033365;positive regulation of cell communication#GO:0010647;regulation of macromolecule metabolic process#GO:0060255;regulation of cell communication#GO:0010646;regulation of chromosome organization#GO:0033044;regulation of response to stimulus#GO:0048583;positive regulation of canonical Wnt signaling pathway#GO:0090263;regulation of telomere maintenance#GO:0032204;intracellular protein localization#GO:0008104;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;macromolecule localization#GO:0033036;positive regulation of cellular process#GO:0048522;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of response to stimulus#GO:0048584;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007 nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 kinase inhibitor#PC00139;kinase modulator#PC00140 HUMAN|HGNC=18455|UniProtKB=Q9HC23 Q9HC23 PROK2 PTHR18821:SF8 PROKINETICIN PROKINETICIN-2 cell population proliferation#GO:0008283;cellular process#GO:0009987;epithelial cell proliferation#GO:0050673;endothelial cell proliferation#GO:0001935 peptide hormone#PC00179 HUMAN|HGNC=22970|UniProtKB=P60409 P60409 KRTAP10-7 PTHR23262:SF227 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 10-7 structural protein#PC00211 HUMAN|HGNC=953|UniProtKB=Q9BZE3 Q9BZE3 BARHL1 PTHR24330:SF8 HOMEOBOX PROTEIN BARH-LIKE BARH-LIKE 1 HOMEOBOX PROTEIN transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=25657|UniProtKB=Q5H9F3 Q5H9F3 BCORL1 PTHR24117:SF6 AGAP007537-PB BCL-6 COREPRESSOR-LIKE PROTEIN 1 transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714;transcription regulator activity#GO:0140110 negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=27091|UniProtKB=A6NKX4 A6NKX4 SLC22A31 PTHR24064:SF196 SOLUTE CARRIER FAMILY 22 MEMBER SOLUTE CARRIER FAMILY 22 MEMBER 31-RELATED transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 cellular process#GO:0009987;transport#GO:0006810;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258 HUMAN|HGNC=3531|UniProtKB=P00488 P00488 F13A1 PTHR11590:SF42 PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE COAGULATION FACTOR XIII A CHAIN aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740 wound healing#GO:0042060;regulation of biological quality#GO:0065008;protein metabolic process#GO:0019538;protein activation cascade#GO:0072376;blood coagulation, fibrin clot formation#GO:0072378;regulation of body fluid levels#GO:0050878;response to stimulus#GO:0050896;hemostasis#GO:0007599;primary metabolic process#GO:0044238;blood coagulation#GO:0007596;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;biological regulation#GO:0065007;biosynthetic process#GO:0009058;multicellular organismal process#GO:0032501;gene expression#GO:0010467;protein maturation#GO:0051604;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;coagulation#GO:0050817;response to stress#GO:0006950;response to wounding#GO:0009611 transferase#PC00220 Blood coagulation#P00011>FXIIIa#P00419;Blood coagulation#P00011>FXIII#P00453 HUMAN|HGNC=21184|UniProtKB=Q4ZHG4 Q4ZHG4 FNDC1 PTHR23197:SF8 TARSH-RELATED FIBRONECTIN DOMAIN-CONTAINING FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN 1 hormone activity#GO:0005179;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545 skeletal muscle tissue development#GO:0007519;muscle structure development#GO:0061061;tissue development#GO:0009888;developmental process#GO:0032502;striated muscle tissue development#GO:0014706;muscle organ development#GO:0007517;skeletal muscle organ development#GO:0060538;animal gross anatomical part developmental process#GO:0160108;muscle tissue development#GO:0060537;animal organ development#GO:0048513;anatomical structure development#GO:0048856 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=4444|UniProtKB=P14770 P14770 GP9 PTHR22650:SF6 GLYCOPROTEIN IB BETA PLATELET GLYCOPROTEIN IX Blood coagulation#P00011>GP IX#P00455 HUMAN|HGNC=8890|UniProtKB=P20142 P20142 PGC PTHR47966:SF72 BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED GASTRICSIN aspartic-type endopeptidase activity#GO:0004190;catalytic activity#GO:0003824;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;cellular process#GO:0009987;proteolysis#GO:0006508;metabolic process#GO:0008152;primary metabolic process#GO:0044238 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 aspartic protease#PC00053;protease#PC00190 HUMAN|HGNC=3529|UniProtKB=P03951 P03951 F11 PTHR24253:SF44 TRANSMEMBRANE PROTEASE SERINE COAGULATION FACTOR XI hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;serine hydrolase activity#GO:0017171;peptidase activity#GO:0008233;catalytic activity#GO:0003824;serine-type peptidase activity#GO:0008236 regulation of response to stress#GO:0080134;negative regulation of blood coagulation#GO:0030195;regulation of response to stimulus#GO:0048583;macromolecule metabolic process#GO:0043170;negative regulation of wound healing#GO:0061045;plasminogen activation#GO:0031639;protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059;regulation of hemostasis#GO:1900046;negative regulation of response to stimulus#GO:0048585;regulation of coagulation#GO:0050818;biological regulation#GO:0065007;biosynthetic process#GO:0009058;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;negative regulation of multicellular organismal process#GO:0051241;metabolic process#GO:0008152;negative regulation of response to wounding#GO:1903035;regulation of response to wounding#GO:1903034;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;gene expression#GO:0010467;regulation of response to external stimulus#GO:0032101;protein maturation#GO:0051604;regulation of multicellular organismal process#GO:0051239;negative regulation of response to external stimulus#GO:0032102;proteolysis#GO:0006508;negative regulation of hemostasis#GO:1900047;negative regulation of coagulation#GO:0050819;regulation of biological quality#GO:0065008;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;zymogen activation#GO:0031638;regulation of body fluid levels#GO:0050878;regulation of blood coagulation#GO:0030193;regulation of wound healing#GO:0061041 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 serine protease#PC00203;protease#PC00190;protein modifying enzyme#PC00260 Blood coagulation#P00011>FXIa#P00434;Blood coagulation#P00011>FXI#P00460 HUMAN|HGNC=17073|UniProtKB=Q9UNA1 Q9UNA1 ARHGAP26 PTHR12552:SF4 OLIGOPHRENIN 1 RHO GTPASE-ACTIVATING PROTEIN 26 enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772 GTPase-activating protein#PC00257 PDGF signaling pathway#P00047>Rho#P01174;Integrin signalling pathway#P00034>GRAF#P00926 HUMAN|HGNC=14265|UniProtKB=Q86UP0 Q86UP0 CDH24 PTHR24027:SF272 CADHERIN-23 CADHERIN-24 cell adhesion molecule binding#GO:0050839;binding#GO:0005488;beta-catenin binding#GO:0008013;protein binding#GO:0005515 cellular component organization or biogenesis#GO:0071840;cell-cell junction organization#GO:0045216;developmental process#GO:0032502;cell-cell junction assembly#GO:0007043;cellular component assembly#GO:0022607;cell migration#GO:0016477;cellular component biogenesis#GO:0044085;cell-cell adhesion#GO:0098609;cellular process#GO:0009987;anatomical structure development#GO:0048856;cell adhesion#GO:0007155;cell motility#GO:0048870;cell morphogenesis#GO:0000902;cell junction organization#GO:0034330;cell junction assembly#GO:0034329;adherens junction organization#GO:0034332;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane protein complex#GO:0098796;membrane#GO:0016020;cell-cell junction#GO:0005911;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;extrinsic component of membrane#GO:0019898;cell junction#GO:0030054;extrinsic component of plasma membrane#GO:0019897;adherens junction#GO:0005912;anchoring junction#GO:0070161 cell adhesion molecule#PC00069;cadherin#PC00057 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HUMAN|HGNC=16225|UniProtKB=Q5VYV7 Q5VYV7 SLX4IP PTHR28557:SF1 PROTEIN SLX4IP PROTEIN SLX4IP HUMAN|HGNC=5962|UniProtKB=P22301 P22301 IL10 PTHR48482:SF5 INTERLEUKIN-19-RELATED INTERLEUKIN-10 molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677;cytokine activity#GO:0005125;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018 negative regulation of response to stimulus#GO:0048585;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of cellular process#GO:0048522;immune response#GO:0006955;regulation of response to stress#GO:0080134;regulation of response to stimulus#GO:0048583;regulation of receptor signaling pathway via JAK-STAT#GO:0046425;negative regulation of inflammatory response#GO:0050728;negative regulation of defense response#GO:0031348;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of receptor signaling pathway via STAT#GO:1904892;regulation of cell communication#GO:0010646;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;positive regulation of receptor signaling pathway via JAK-STAT#GO:0046427;cytokine-mediated signaling pathway#GO:0019221;regulation of inflammatory response#GO:0050727;regulation of defense response#GO:0031347;regulation of response to external stimulus#GO:0032101;response to chemical#GO:0042221;response to cytokine#GO:0034097;negative regulation of response to external stimulus#GO:0032102;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cell surface receptor signaling pathway#GO:0007166;response to stimulus#GO:0050896;signaling#GO:0023052;negative regulation of biological process#GO:0048519;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;positive regulation of signaling#GO:0023056;response to peptide#GO:1901652;immune system process#GO:0002376;regulation of signaling#GO:0023051 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 Interleukin signaling pathway#P00036>Interleukin#P00970 HUMAN|HGNC=330|UniProtKB=O00253 O00253 AGRP PTHR16551:SF4 AGOUTI RELATED AGOUTI-RELATED PROTEIN protein binding#GO:0005515;hormone activity#GO:0005179;molecular function activator activity#GO:0140677;binding#GO:0005488;signaling receptor binding#GO:0005102;neuropeptide hormone activity#GO:0005184;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;signaling receptor regulator activity#GO:0030545;neuropeptide receptor binding#GO:0071855;receptor ligand activity#GO:0048018;G protein-coupled receptor binding#GO:0001664 feeding behavior#GO:0007631;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;positive regulation of multicellular organismal process#GO:0051240;regulation of biological process#GO:0050789;neuropeptide signaling pathway#GO:0007218 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HUMAN|HGNC=13265|UniProtKB=Q9HBI6 Q9HBI6 CYP4F11 PTHR24291:SF198 CYTOCHROME P450 FAMILY 4 CYTOCHROME P450 4F11 metabolite interconversion enzyme#PC00262;oxygenase#PC00177;oxidoreductase#PC00176 HUMAN|HGNC=5965|UniProtKB=Q08334 Q08334 IL10RB PTHR20859:SF50 INTERFERON/INTERLEUKIN RECEPTOR INTERLEUKIN-10 RECEPTOR SUBUNIT BETA signaling receptor activity#GO:0038023;immune receptor activity#GO:0140375;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;cytokine receptor activity#GO:0004896 response to stimulus#GO:0050896;response to chemical#GO:0042221;response to cytokine#GO:0034097;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;cellular response to cytokine stimulus#GO:0071345;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;response to peptide#GO:1901652;cytokine-mediated signaling pathway#GO:0019221;cell surface receptor signaling pathway#GO:0007166 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Cytokine receptor#P00866;Interleukin signaling pathway#P00036>Receptor subunit beta#P00974 HUMAN|HGNC=9668|UniProtKB=P23468 P23468 PTPRD PTHR19134:SF430 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE DELTA phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824 signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell junction organization#GO:0034330;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular component organization#GO:0016043;system development#GO:0048731;synaptic membrane adhesion#GO:0099560;cell communication#GO:0007154;anatomical structure development#GO:0048856;cell adhesion#GO:0007155;synapse organization#GO:0050808;animal gross anatomical part developmental process#GO:0160108;biological regulation#GO:0065007;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;signal transduction#GO:0007165;cellular process#GO:0009987;cell-cell adhesion#GO:0098609;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;developmental process#GO:0032502 protein modifying enzyme#PC00260;protein phosphatase#PC00195 HUMAN|HGNC=3050|UniProtKB=P32926 P32926 DSG3 PTHR24025:SF3 DESMOGLEIN FAMILY MEMBER DESMOGLEIN-3 calcium ion binding#GO:0005509;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;cation binding#GO:0043169;metal ion binding#GO:0046872 cell adhesion#GO:0007155;cellular process#GO:0009987;cell-cell adhesion#GO:0098609 cell-cell junction#GO:0005911;cell junction#GO:0030054;cellular anatomical structure#GO:0110165;anchoring junction#GO:0070161 cadherin#PC00057 HUMAN|HGNC=4545|UniProtKB=P43250 P43250 GRK6 PTHR24355:SF15 G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE G PROTEIN-COUPLED RECEPTOR KINASE 6 transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 regulation of biological process#GO:0050789;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cell communication#GO:0010646 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GPRK#P00701;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GPRK#P00741;Angiotensin II-stimulated signaling through G proteins and beta-arrestin#P05911>GRK6#P05939;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>GPRK#P00840 HUMAN|HGNC=24578|UniProtKB=Q5TDH0 Q5TDH0 DDI2 PTHR12917:SF13 ASPARTYL PROTEASE DDI-RELATED PROTEIN DDI1 HOMOLOG 2 catalytic activity#GO:0003824;aspartic-type endopeptidase activity#GO:0004190;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175 proteasomal protein catabolic process#GO:0010498;biological regulation#GO:0065007;catabolic process#GO:0009056;cellular process#GO:0009987;regulation of protein stability#GO:0031647;primary metabolic process#GO:0044238;regulation of biological quality#GO:0065008;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;proteolysis#GO:0006508 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 aspartic protease#PC00053;protein modifying enzyme#PC00260 HUMAN|HGNC=10741|UniProtKB=O75326 O75326 SEMA7A PTHR11036:SF80 SEMAPHORIN SEMAPHORIN-7A molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;integrin binding#GO:0005178;cell adhesion molecule binding#GO:0050839;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;molecular function activator activity#GO:0140677;protein-containing complex binding#GO:0044877;protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 neuron development#GO:0048666;axonogenesis#GO:0007409;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;cell projection organization#GO:0030030;response to stimulus#GO:0050896;cell differentiation#GO:0030154;cell morphogenesis#GO:0000902;signaling#GO:0023052;cell development#GO:0048468;positive regulation of cell motility#GO:2000147;integrin-mediated signaling pathway#GO:0007229;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cell projection morphogenesis#GO:0048858;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell surface receptor signaling pathway#GO:0007166;taxis#GO:0042330;response to chemical#GO:0042221;regulation of response to external stimulus#GO:0032101;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;neuron projection development#GO:0031175;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of cell motility#GO:2000145;cell communication#GO:0007154;anatomical structure development#GO:0048856;system development#GO:0048731;chemotaxis#GO:0006935;regulation of inflammatory response#GO:0050727;regulation of defense response#GO:0031347;regulation of cellular process#GO:0050794;locomotion#GO:0040011;cellular response to stimulus#GO:0051716;cellular developmental process#GO:0048869;positive regulation of locomotion#GO:0040017;neuron projection guidance#GO:0097485;response to external stimulus#GO:0009605;neurogenesis#GO:0022008;regulation of response to stress#GO:0080134;regulation of cell migration#GO:0030334;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;regulation of response to stimulus#GO:0048583;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;plasma membrane bounded cell projection organization#GO:0120036;axon guidance#GO:0007411;axon development#GO:0061564;positive regulation of cellular process#GO:0048522;positive regulation of cell migration#GO:0030335 cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;plasma membrane#GO:0005886;membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944 membrane-bound signaling molecule#PC00152 HUMAN|HGNC=18197|UniProtKB=Q05BV3 Q05BV3 EML5 PTHR13720:SF16 WD-40 REPEAT PROTEIN ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 5 protein binding#GO:0005515;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;microtubule binding#GO:0008017 microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=8677|UniProtKB=Q9Y5I4 Q9Y5I4 PCDHAC2 PTHR24028:SF119 CADHERIN-87A PROTOCADHERIN ALPHA-C2 cell adhesion#GO:0007155;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 cadherin#PC00057;cell adhesion molecule#PC00069 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HUMAN|HGNC=27406|UniProtKB=C9JVW0 C9JVW0 INAFM1 PTHR34929:SF2 ZGC:153157 TRANSMEMBRANE PROTEIN INAFM1-RELATED HUMAN|HGNC=10594|UniProtKB=Q01118 Q01118 SCN7A PTHR10037:SF14 VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM SODIUM CHANNEL PROTEIN TYPE 7 SUBUNIT ALPHA sodium channel activity#GO:0005272;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;metal ion transmembrane transporter activity#GO:0046873;voltage-gated sodium channel activity#GO:0005248;sodium ion transmembrane transporter activity#GO:0015081;monoatomic cation channel activity#GO:0005261;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267 monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;transport#GO:0006810;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;system process#GO:0003008;transmission of nerve impulse#GO:0019226;monoatomic ion homeostasis#GO:0050801;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;multicellular organismal process#GO:0032501;monoatomic cation transmembrane transport#GO:0098655;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;sensory perception#GO:0007600;inorganic ion homeostasis#GO:0098771;nervous system process#GO:0050877;localization#GO:0051179;cell communication#GO:0007154;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;sensory perception of pain#GO:0019233;action potential#GO:0001508;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;membrane depolarization#GO:0051899;homeostatic process#GO:0042592 plasma membrane#GO:0005886;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020;transporter complex#GO:1990351;cation channel complex#GO:0034703;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;sodium channel complex#GO:0034706;transmembrane transporter complex#GO:1902495;axon#GO:0030424 voltage-gated ion channel#PC00241 HUMAN|HGNC=4796|UniProtKB=P46952 P46952 HAAO PTHR15497:SF1 3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE 3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE oxygenase#PC00177 HUMAN|HGNC=16850|UniProtKB=Q6PD62 Q6PD62 CTR9 PTHR14027:SF2 RNA POLYMERASE-ASSOCIATED PROTEIN CTR9 RNA POLYMERASE-ASSOCIATED PROTEIN CTR9 HOMOLOG RNA polymerase core enzyme binding#GO:0043175;protein binding#GO:0005515;RNA polymerase II complex binding#GO:0000993;RNA polymerase binding#GO:0070063;enzyme binding#GO:0019899;binding#GO:0005488 gene expression#GO:0010467;transcription elongation by RNA polymerase II#GO:0006368;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;DNA-templated transcription elongation#GO:0006354;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;transcription by RNA polymerase II#GO:0006366;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187 nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;Cdc73/Paf1 complex#GO:0016593;transferase complex#GO:1990234;protein-containing complex#GO:0032991;membrane-enclosed lumen#GO:0031974;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;RNA polymerase II, holoenzyme#GO:0016591;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;transcription elongation factor complex#GO:0008023;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029 general transcription factor#PC00259;RNA metabolism protein#PC00031 HUMAN|HGNC=6388|UniProtKB=P52732 P52732 KIF11 PTHR47970:SF26 KINESIN-LIKE PROTEIN KIF11 KINESIN-LIKE PROTEIN KIF11 cytoskeletal motor activity#GO:0003774;isomerase activity#GO:0016853;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543;plus-end-directed microtubule motor activity#GO:0008574;microtubule motor activity#GO:0003777;polypeptide conformation or assembly isomerase activity#GO:0120544;ATP-dependent activity#GO:0140657 organelle fission#GO:0048285;microtubule cytoskeleton organization#GO:0000226;nuclear division#GO:0000280;organelle assembly#GO:0070925;mitotic spindle organization#GO:0007052;mitotic cell cycle#GO:0000278;cell cycle process#GO:0022402;mitotic nuclear division#GO:0140014;sister chromatid segregation#GO:0000819;nuclear chromosome segregation#GO:0098813;cellular component organization#GO:0016043;microtubule cytoskeleton organization involved in mitosis#GO:1902850;membraneless organelle assembly#GO:0140694;cell cycle#GO:0007049;chromosome organization#GO:0051276;microtubule-based process#GO:0007017;mitotic cell cycle process#GO:1903047;cellular component organization or biogenesis#GO:0071840;spindle organization#GO:0007051;chromosome segregation#GO:0007059;spindle elongation#GO:0051231;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;cellular process#GO:0009987;mitotic spindle assembly#GO:0090307;spindle assembly#GO:0051225;cellular component biogenesis#GO:0044085;mitotic sister chromatid segregation#GO:0000070;organelle organization#GO:0006996 cytoskeleton#GO:0005856;spindle#GO:0005819;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;microtubule cytoskeleton#GO:0015630;nucleus#GO:0005634;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232;intracellular organelle#GO:0043229;spindle microtubule#GO:0005876;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;supramolecular fiber#GO:0099512;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;mitotic spindle#GO:0072686 microtubule binding motor protein#PC00156 HUMAN|HGNC=21446|UniProtKB=Q96S86 Q96S86 HAPLN3 PTHR22804:SF40 AGGRECAN/VERSICAN PROTEOGLYCAN HYALURONAN AND PROTEOGLYCAN LINK PROTEIN 3 animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502;anatomical structure development#GO:0048856;multicellular organism development#GO:0007275;skeletal system development#GO:0001501;system development#GO:0048731;multicellular organismal process#GO:0032501;central nervous system development#GO:0007417;nervous system development#GO:0007399 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;synapse#GO:0045202;cell periphery#GO:0071944;membrane#GO:0016020;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cell junction#GO:0030054;extracellular region#GO:0005576 extracellular matrix protein#PC00102;extracellular matrix glycoprotein#PC00100 HUMAN|HGNC=20690|UniProtKB=Q6IV72 Q6IV72 ZNF425 PTHR24381:SF438 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 425 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=25755|UniProtKB=Q96IZ6 Q96IZ6 METTL2A PTHR22809:SF4 METHYLTRANSFERASE-RELATED TRNA N(3)-CYTIDINE METHYLTRANSFERASE METTL2A-RELATED tRNA methyltransferase activity#GO:0008175;RNA methyltransferase activity#GO:0008173;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a tRNA#GO:0140101;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168 methyltransferase#PC00155 HUMAN|HGNC=24882|UniProtKB=Q9H4A5 Q9H4A5 GOLPH3L PTHR12704:SF4 TRANS-GOLGI PROTEIN GMX33 GOLGI PHOSPHOPROTEIN 3-LIKE phospholipid binding#GO:0005543;molecular adaptor activity#GO:0060090;phosphatidylinositol phosphate binding#GO:1901981;small molecule binding#GO:0036094;binding#GO:0005488;anion binding#GO:0043168;protein-macromolecule adaptor activity#GO:0030674;ion binding#GO:0043167;cargo adaptor activity#GO:0140312;lipid binding#GO:0008289 membrane organization#GO:0061024;endomembrane system organization#GO:0010256;vesicle-mediated transport#GO:0016192;establishment of protein localization#GO:0045184;cellular process#GO:0009987;establishment of protein localization to membrane#GO:0090150;macromolecule localization#GO:0033036;organelle organization#GO:0006996;intracellular protein localization#GO:0008104;vesicle-mediated transport to the plasma membrane#GO:0098876;vesicle budding from membrane#GO:0006900;vesicle organization#GO:0016050;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;transport#GO:0006810;Golgi vesicle transport#GO:0048193;protein localization to cell periphery#GO:1990778;Golgi to plasma membrane protein transport#GO:0043001;Golgi to plasma membrane transport#GO:0006893;Golgi organization#GO:0007030;protein localization to membrane#GO:0072657;protein localization to plasma membrane#GO:0072659;cellular component organization#GO:0016043;post-Golgi vesicle-mediated transport#GO:0006892;protein transport#GO:0015031;localization#GO:0051179;cellular localization#GO:0051641;establishment of protein localization to plasma membrane#GO:0061951;localization within membrane#GO:0051668 intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;trans-Golgi network#GO:0005802;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;Golgi apparatus subcompartment#GO:0098791;cytosol#GO:0005829 HUMAN|HGNC=2877|UniProtKB=O60879 O60879 DIAPH2 PTHR45691:SF3 PROTEIN DIAPHANOUS PROTEIN DIAPHANOUS HOMOLOG 2 cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;cellular process#GO:0009987;actin polymerization or depolymerization#GO:0008154;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;actin filament organization#GO:0007015;cellular component organization or biogenesis#GO:0071840;actin cytoskeleton organization#GO:0030036;actin filament polymerization#GO:0030041;protein-containing complex assembly#GO:0065003;protein polymerization#GO:0051258;cellular component organization#GO:0016043;supramolecular fiber organization#GO:0097435;actin filament-based process#GO:0030029 cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;organelle#GO:0043226;supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232;actin cytoskeleton#GO:0015629;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;cytoskeleton#GO:0005856;actin filament#GO:0005884;intracellular organelle#GO:0043229 cytoskeletal protein#PC00085 Cytoskeletal regulation by Rho GTPase#P00016>mDia#P00510 HUMAN|HGNC=13257|UniProtKB=Q9UMR7 Q9UMR7 CLEC4A PTHR22802:SF426 C-TYPE LECTIN SUPERFAMILY MEMBER C-TYPE LECTIN DOMAIN FAMILY 4 MEMBER A binding#GO:0005488;signaling receptor activity#GO:0038023;carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187;molecular transducer activity#GO:0060089 response to stimulus#GO:0050896;defense response to other organism#GO:0098542;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;defense response to fungus#GO:0050832;response to other organism#GO:0051707;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;defense response to symbiont#GO:0140546;immune response#GO:0006955;innate immune response#GO:0045087;response to external stimulus#GO:0009605;defense response#GO:0006952;immune system process#GO:0002376 membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;plasma membrane#GO:0005886 membrane traffic protein#PC00150 HUMAN|HGNC=12869|UniProtKB=P17010 P17010 ZFX PTHR24406:SF6 TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED ZINC FINGER X-CHROMOSOMAL PROTEIN C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HUMAN|HGNC=8670|UniProtKB=Q9UN74 Q9UN74 PCDHA4 PTHR24028:SF357 CADHERIN-87A PROTOCADHERIN ALPHA-4 cellular process#GO:0009987;cell adhesion#GO:0007155 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 cadherin#PC00057;cell adhesion molecule#PC00069 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HUMAN|HGNC=28428|UniProtKB=Q9BUL5 Q9BUL5 PHF23 PTHR14571:SF8 HISTONE-LYSINE N-METHYLTRANSFERASE SET-26-RELATED PHD FINGER PROTEIN 23 regulation of autophagosome assembly#GO:2000785;positive regulation of protein metabolic process#GO:0051247;positive regulation of metabolic process#GO:0009893;regulation of post-translational protein modification#GO:1901873;regulation of protein modification by small protein conjugation or removal#GO:1903320;negative regulation of biological process#GO:0048519;regulation of autophagy#GO:0010506;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of cellular component organization#GO:0051128;regulation of cellular component biogenesis#GO:0044087;negative regulation of metabolic process#GO:0009892;regulation of macroautophagy#GO:0016241;regulation of protein metabolic process#GO:0051246;regulation of protein-containing complex disassembly#GO:0043244;positive regulation of biological process#GO:0048518;negative regulation of macroautophagy#GO:0016242;positive regulation of protein ubiquitination#GO:0031398;positive regulation of macromolecule metabolic process#GO:0010604;negative regulation of protein-containing complex disassembly#GO:0043242;negative regulation of catabolic process#GO:0009895;negative regulation of cellular component organization#GO:0051129;negative regulation of organelle organization#GO:0010639;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of cellular process#GO:0048523;regulation of protein ubiquitination#GO:0031396;regulation of autophagosome maturation#GO:1901096;regulation of catabolic process#GO:0009894;regulation of protein modification process#GO:0031399;negative regulation of autophagy#GO:0010507;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;regulation of organelle assembly#GO:1902115;biological regulation#GO:0065007 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=29536|UniProtKB=O60336 O60336 MAPKBP1 PTHR44813:SF1 MITOGEN-ACTIVATED PROTEIN KINASE-BINDING PROTEIN 1 MITOGEN-ACTIVATED PROTEIN KINASE-BINDING PROTEIN 1 HUMAN|HGNC=8290|UniProtKB=Q8NGF8 Q8NGF8 OR4B1 PTHR48002:SF123 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 4B1 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=26361|UniProtKB=Q14CZ8 Q14CZ8 HEPACAM PTHR12080:SF59 SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE HEPATIC AND GLIAL CELL ADHESION MOLECULE signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 intracellular protein localization#GO:0008104;cell communication#GO:0007154;localization#GO:0051179;protein localization to cell junction#GO:1902414;immune system process#GO:0002376;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;immune response#GO:0006955;regulation of biological process#GO:0050789;signal transduction#GO:0007165;macromolecule localization#GO:0033036 anchoring junction#GO:0070161;cell junction#GO:0030054;cellular anatomical structure#GO:0110165;cell-cell junction#GO:0005911 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=2121|UniProtKB=Q99788 Q99788 CMKLR1 PTHR24225:SF49 CHEMOTACTIC RECEPTOR CHEMERIN-LIKE RECEPTOR 1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;immune receptor activity#GO:0140375;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;G protein-coupled receptor signaling pathway#GO:0007186;immune system process#GO:0002376;positive regulation of cytosolic calcium ion concentration#GO:0007204;regulation of biological quality#GO:0065008;immune response-regulating signaling pathway#GO:0002764;regulation of biological process#GO:0050789;positive regulation of cell motility#GO:2000147;regulation of chemotaxis#GO:0050920;signaling#GO:0023052;response to stimulus#GO:0050896;cell surface receptor signaling pathway#GO:0007166;positive regulation of response to external stimulus#GO:0032103;immune response-activating signaling pathway#GO:0002757;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;positive regulation of immune system process#GO:0002684;regulation of response to external stimulus#GO:0032101;taxis#GO:0042330;response to chemical#GO:0042221;phospholipase C-activating G protein-coupled receptor signaling pathway#GO:0007200;regulation of granulocyte chemotaxis#GO:0071622;regulation of immune response#GO:0050776;chemotaxis#GO:0006935;positive regulation of chemotaxis#GO:0050921;cell communication#GO:0007154;regulation of cell motility#GO:2000145;cellular response to stimulus#GO:0051716;immune response-activating cell surface receptor signaling pathway#GO:0002429;regulation of cell communication#GO:0010646;locomotion#GO:0040011;regulation of calcium-mediated signaling#GO:0050848;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of leukocyte migration#GO:0002685;regulation of response to stimulus#GO:0048583;regulation of cell migration#GO:0030334;positive regulation of immune response#GO:0050778;response to external stimulus#GO:0009605;positive regulation of locomotion#GO:0040017;positive regulation of cell migration#GO:0030335;positive regulation of cellular process#GO:0048522;regulation of locomotion#GO:0040012;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;positive regulation of response to stimulus#GO:0048584 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=19076|UniProtKB=O95873 O95873 C6orf47 PTHR14307:SF0 C6ORF47 FAMILY MEMBER SI:CH73-25F10.6 HUMAN|HGNC=315|UniProtKB=Q9Y4W6 Q9Y4W6 AFG3L2 PTHR43655:SF9 ATP-DEPENDENT PROTEASE MITOCHONDRIAL INNER MEMBRANE M-AAA PROTEASE COMPONENT AFG3L2 peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;proteolysis#GO:0006508;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 inner mitochondrial membrane protein complex#GO:0098800;organelle membrane#GO:0031090;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrial membrane#GO:0031966;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;cytoplasm#GO:0005737;peptidase complex#GO:1905368;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;membrane protein complex#GO:0098796;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 metalloprotease#PC00153;protease#PC00190 HUMAN|HGNC=29215|UniProtKB=Q9ULL8 Q9ULL8 SHROOM4 PTHR15012:SF35 APICAL PROTEIN/SHROOM-RELATED PROTEIN SHROOM4 actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;actin filament binding#GO:0051015;binding#GO:0005488;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 actin filament-based process#GO:0030029;cellular component organization or biogenesis#GO:0071840;actin filament organization#GO:0007015;supramolecular fiber organization#GO:0097435;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;actin cytoskeleton organization#GO:0030036;cytoskeleton organization#GO:0007010 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cell cortex#GO:0005938;cortical cytoskeleton#GO:0030863;apical plasma membrane#GO:0016324;actin cytoskeleton#GO:0015629;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;intracellular organelle#GO:0043229;cortical actin cytoskeleton#GO:0030864;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;plasma membrane region#GO:0098590;cell periphery#GO:0071944;cell-cell junction#GO:0005911;membrane#GO:0016020;adherens junction#GO:0005912;membraneless organelle#GO:0043228;cell junction#GO:0030054;apical part of cell#GO:0045177;cytoskeleton#GO:0005856;apical junction complex#GO:0043296 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=17381|UniProtKB=O14492 O14492 SH2B2 PTHR10872:SF4 SH2B ADAPTER PROTEIN SH2B ADAPTER PROTEIN 2 protein binding#GO:0005515;signaling adaptor activity#GO:0035591;transmembrane receptor protein tyrosine kinase adaptor activity#GO:0005068;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;protein-macromolecule adaptor activity#GO:0030674;binding#GO:0005488;signaling receptor binding#GO:0005102;kinase binding#GO:0019900;protein tyrosine kinase binding#GO:1990782;receptor tyrosine kinase binding#GO:0030971;molecular adaptor activity#GO:0060090;signaling receptor complex adaptor activity#GO:0030159 immune response-activating signaling pathway#GO:0002757;regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166;positive regulation of immune response#GO:0050778;antigen receptor-mediated signaling pathway#GO:0050851;positive regulation of response to stimulus#GO:0048584;immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007;positive regulation of immune system process#GO:0002684;cellular process#GO:0009987;B cell receptor signaling pathway#GO:0050853;signal transduction#GO:0007165;activation of immune response#GO:0002253;positive regulation of biological process#GO:0048518;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;immune system process#GO:0002376;regulation of immune response#GO:0050776;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;response to stimulus#GO:0050896;immune response-activating cell surface receptor signaling pathway#GO:0002429;signaling#GO:0023052;cellular response to stimulus#GO:0051716;immune response-regulating signaling pathway#GO:0002764;regulation of biological process#GO:0050789 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HUMAN|HGNC=17155|UniProtKB=Q9Y3P9 Q9Y3P9 RABGAP1 PTHR47219:SF6 RAB GTPASE-ACTIVATING PROTEIN 1-LIKE RAB GTPASE-ACTIVATING PROTEIN 1 enzyme regulator activity#GO:0030234;small GTPase binding#GO:0031267;protein binding#GO:0005515;molecular function activator activity#GO:0140677;binding#GO:0005488;enzyme binding#GO:0019899;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047 GTPase-activating protein#PC00257;G-protein modulator#PC00022 HUMAN|HGNC=25262|UniProtKB=Q5SNV9 Q5SNV9 C1orf167 PTHR38493:SF1 CHROMOSOME 1 OPEN READING FRAME 167 SFI1 SPINDLE BODY DOMAIN-CONTAINING PROTEIN HUMAN|HGNC=28622|UniProtKB=Q8N6G2 Q8N6G2 TEX26 PTHR33769:SF1 TESTIS-EXPRESSED PROTEIN 26 ISOFORM X3 TESTIS-EXPRESSED PROTEIN 26 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=633|UniProtKB=P29972 P29972 AQP1 PTHR19139:SF161 AQUAPORIN TRANSPORTER AQUAPORIN-1 channel activity#GO:0015267;carbohydrate transmembrane transporter activity#GO:0015144;water channel activity#GO:0015250;water transmembrane transporter activity#GO:0005372;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;passive transmembrane transporter activity#GO:0022803 response to abiotic stimulus#GO:0009628;hyperosmotic response#GO:0006972;homeostatic process#GO:0042592;regulation of body fluid levels#GO:0050878;response to stimulus#GO:0050896;regulation of biological quality#GO:0065008;fluid transport#GO:0042044;transmembrane transport#GO:0055085;localization#GO:0051179;cellular process#GO:0009987;renal system process#GO:0003014;response to stress#GO:0006950;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;chemical homeostasis#GO:0048878;transport#GO:0006810;response to osmotic stress#GO:0006970;multicellular organismal-level homeostasis#GO:0048871;system process#GO:0003008;establishment of localization#GO:0051234;water transport#GO:0006833 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227 HUMAN|HGNC=13871|UniProtKB=Q16630 Q16630 CPSF6 PTHR23204:SF3 CLEAVAGE AND POLYADENYLATION SPECIFIC FACTOR CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 6 RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676 mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;RNA 3'-end processing#GO:0031123;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;mRNA 3'-end processing#GO:0031124;nucleobase-containing compound biosynthetic process#GO:0034654 mRNA cleavage and polyadenylation specificity factor complex#GO:0005847;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;mRNA cleavage factor complex#GO:0005849;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HUMAN|HGNC=4247|UniProtKB=P38435 P38435 GGCX PTHR12639:SF6 VITAMIN K-DEPENDENT GAMMA-CARBOXYLASE VITAMIN K-DEPENDENT GAMMA-CARBOXYLASE carbon-carbon lyase activity#GO:0016830;carboxy-lyase activity#GO:0016831;catalytic activity#GO:0003824;small molecule binding#GO:0036094;binding#GO:0005488;lyase activity#GO:0016829 cellular process#GO:0009987;vitamin K metabolic process#GO:0042373;ketone metabolic process#GO:0042180;metabolic process#GO:0008152 HUMAN|HGNC=20858|UniProtKB=Q15043 Q15043 SLC39A14 PTHR12191:SF5 SOLUTE CARRIER FAMILY 39 METAL CATION SYMPORTER ZIP14 symporter activity#GO:0015293;transition metal ion transmembrane transporter activity#GO:0046915;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;secondary active transmembrane transporter activity#GO:0015291;zinc ion transmembrane transporter activity#GO:0005385;bicarbonate transmembrane transporter activity#GO:0015106;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294 monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;zinc ion transport#GO:0006829;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;intracellular monoatomic cation homeostasis#GO:0030003;transport#GO:0006810;establishment of localization#GO:0051234;import into cell#GO:0098657;cellular homeostasis#GO:0019725;inorganic cation import across plasma membrane#GO:0098659;intracellular chemical homeostasis#GO:0055082;intracellular monoatomic ion homeostasis#GO:0006873;import across plasma membrane#GO:0098739;inorganic ion import across plasma membrane#GO:0099587;metal ion transport#GO:0030001;homeostatic process#GO:0042592;transition metal ion transport#GO:0000041;zinc ion transmembrane transport#GO:0071577;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 HUMAN|HGNC=11931|UniProtKB=O95150 O95150 TNFSF15 PTHR11471:SF24 TUMOR NECROSIS FACTOR FAMILY MEMBER TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 15 receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;cytokine activity#GO:0005125;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546 positive regulation of response to stimulus#GO:0048584;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of cellular process#GO:0048522;regulation of canonical NF-kappaB signal transduction#GO:0043122;positive regulation of extrinsic apoptotic signaling pathway#GO:2001238;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;positive regulation of apoptotic signaling pathway#GO:2001235;regulation of cell communication#GO:0010646;regulation of extrinsic apoptotic signaling pathway#GO:2001236;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;regulation of apoptotic signaling pathway#GO:2001233;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of apoptotic process#GO:0043065;positive regulation of canonical NF-kappaB signal transduction#GO:0043123;cell surface receptor signaling pathway#GO:0007166;regulation of apoptotic process#GO:0042981;response to stimulus#GO:0050896;positive regulation of programmed cell death#GO:0043068;signaling#GO:0023052;regulation of programmed cell death#GO:0043067;regulation of biological process#GO:0050789;positive regulation of signaling#GO:0023056;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HUMAN|HGNC=30636|UniProtKB=Q96A04 Q96A04 TSACC PTHR37368:SF1 TSSK6-ACTIVATING CO-CHAPERONE PROTEIN TSSK6-ACTIVATING CO-CHAPERONE PROTEIN binding#GO:0005488;protein-folding chaperone binding#GO:0051087;protein binding#GO:0005515 regulation of cellular process#GO:0050794;positive regulation of metabolic process#GO:0009893;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789;positive regulation of cellular process#GO:0048522 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular protein-containing complex#GO:0140535;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;protein folding chaperone complex#GO:0101031 chaperone#PC00072 HUMAN|HGNC=1149|UniProtKB=O60566 O60566 BUB1B PTHR14030:SF29 MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1 MITOTIC CHECKPOINT SERINE_THREONINE-PROTEIN KINASE BUB1 BETA catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 negative regulation of chromosome segregation#GO:0051985;negative regulation of metaphase/anaphase transition of cell cycle#GO:1902100;regulation of chromosome segregation#GO:0051983;negative regulation of mitotic sister chromatid segregation#GO:0033048;cellular component organization or biogenesis#GO:0071840;negative regulation of cell cycle#GO:0045786;meiotic sister chromatid cohesion#GO:0051177;organelle organization#GO:0006996;negative regulation of sister chromatid segregation#GO:0033046;signal transduction#GO:0007165;mitotic spindle assembly checkpoint signaling#GO:0007094;cellular process#GO:0009987;negative regulation of mitotic cell cycle phase transition#GO:1901991;cell cycle checkpoint signaling#GO:0000075;regulation of chromosome separation#GO:1905818;regulation of cell cycle process#GO:0010564;negative regulation of mitotic sister chromatid separation#GO:2000816;regulation of mitotic cell cycle phase transition#GO:1901990;negative regulation of mitotic cell cycle#GO:0045930;negative regulation of biological process#GO:0048519;negative regulation of cell cycle phase transition#GO:1901988;cellular component organization#GO:0016043;negative regulation of mitotic nuclear division#GO:0045839;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;cell cycle process#GO:0022402;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;regulation of cell cycle#GO:0051726;signaling#GO:0023052;regulation of sister chromatid segregation#GO:0033045;regulation of chromosome organization#GO:0033044;negative regulation of cellular process#GO:0048523;negative regulation of cell cycle process#GO:0010948;regulation of mitotic sister chromatid separation#GO:0010965;regulation of mitotic nuclear division#GO:0007088;negative regulation of chromosome separation#GO:1905819;mitotic cell cycle process#GO:1903047;chromosome organization#GO:0051276;regulation of mitotic cell cycle#GO:0007346;regulation of mitotic metaphase/anaphase transition#GO:0030071;biological regulation#GO:0065007;regulation of nuclear division#GO:0051783;negative regulation of nuclear division#GO:0051784;negative regulation of chromosome organization#GO:2001251;cell communication#GO:0007154;sister chromatid cohesion#GO:0007062;regulation of mitotic sister chromatid segregation#GO:0033047;intracellular signal transduction#GO:0035556;regulation of cell cycle phase transition#GO:1901987;mitotic cell cycle checkpoint signaling#GO:0007093;cell cycle#GO:0007049;negative regulation of cellular component organization#GO:0051129;negative regulation of organelle organization#GO:0010639;cellular response to stimulus#GO:0051716;negative regulation of mitotic metaphase/anaphase transition#GO:0045841;mitotic cell cycle#GO:0000278;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;regulation of cellular process#GO:0050794 intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;kinetochore#GO:0000776;chromosome#GO:0005694;membraneless organelle#GO:0043228;condensed chromosome#GO:0000793;chromosome, centromeric region#GO:0000775;intracellular membraneless organelle#GO:0043232;supramolecular complex#GO:0099080;nucleus#GO:0005634;condensed chromosome, centromeric region#GO:0000779 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=24484|UniProtKB=Q9NVH2 Q9NVH2 INTS7 PTHR13322:SF2 C1ORF73 PROTEIN INTEGRATOR COMPLEX SUBUNIT 7 gene expression#GO:0010467;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;nucleobase-containing compound catabolic process#GO:0034655;transcription initiation at RNA polymerase II promoter#GO:0006367;macromolecule biosynthetic process#GO:0009059;nucleic acid catabolic process#GO:0141188;cellular process#GO:0009987;RNA 3'-end processing#GO:0031123;macromolecule metabolic process#GO:0043170;snRNA processing#GO:0016180;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule catabolic process#GO:0009057;transcription by RNA polymerase II#GO:0006366;catabolic process#GO:0009056;DNA-templated transcription initiation#GO:0006352;RNA biosynthetic process#GO:0032774;snRNA 3'-end processing#GO:0034472;DNA-templated transcription#GO:0006351;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;snRNA metabolic process#GO:0016073;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA catabolic process#GO:0006401 intracellular organelle#GO:0043229;integrator complex#GO:0032039;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=30511|UniProtKB=Q5BJH7 Q5BJH7 YIF1B PTHR14083:SF1 YIP1 INTERACTING FACTOR HOMOLOG YIF1 PROTEIN PROTEIN YIF1B cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;transport#GO:0006810;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649 endoplasmic reticulum#GO:0005783;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane#GO:0016020;cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;coated vesicle#GO:0030135;COPII-coated ER to Golgi transport vesicle#GO:0030134;vesicle#GO:0031982;intracellular vesicle#GO:0097708;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=24753|UniProtKB=Q17RG1 Q17RG1 KCTD19 PTHR14499:SF20 POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD19 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 scaffold/adaptor protein#PC00226 HUMAN|HGNC=15957|UniProtKB=Q8IUB2 Q8IUB2 WFDC3 PTHR19441:SF97 WAP four-disulfide core domain protein WAP FOUR-DISULFIDE CORE DOMAIN PROTEIN 3 enzyme inhibitor activity#GO:0004857;endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414;peptidase regulator activity#GO:0061134;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;serine-type endopeptidase inhibitor activity#GO:0004867 humoral immune response#GO:0006959;antimicrobial humoral response#GO:0019730;innate immune response#GO:0045087;antibacterial humoral response#GO:0019731;response to external stimulus#GO:0009605;defense response#GO:0006952;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;defense response to symbiont#GO:0140546;immune response#GO:0006955;defense response to other organism#GO:0098542;response to other organism#GO:0051707;response to bacterium#GO:0009617;immune system process#GO:0002376;defense response to bacterium#GO:0042742;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HUMAN|HGNC=26181|UniProtKB=Q96G75 Q96G75 RMND5B PTHR12170:SF6 MACROPHAGE ERYTHROBLAST ATTACHER-RELATED E3 UBIQUITIN-PROTEIN TRANSFERASE RMND5B catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787 ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex#GO:1990234;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 HUMAN|HGNC=7514|UniProtKB=Q99102 Q99102 MUC4 PTHR13802:SF66 MUCIN 4-RELATED MUCIN-4 digestion#GO:0007586;anatomical structure homeostasis#GO:0060249;multicellular organismal process#GO:0032501;homeostatic process#GO:0042592;epithelial structure maintenance#GO:0010669;system process#GO:0003008;tissue homeostasis#GO:0001894;multicellular organismal-level homeostasis#GO:0048871 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 HUMAN|HGNC=2928|UniProtKB=P11532 P11532 DMD PTHR12268:SF25 E3 UBIQUITIN-PROTEIN LIGASE KCMF1 DYSTROPHIN nervous system development#GO:0007399;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;tissue development#GO:0009888;skeletal muscle tissue development#GO:0007519;cellular process#GO:0009987;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;animal organ development#GO:0048513;multicellular organism development#GO:0007275;neuron differentiation#GO:0030182;striated muscle tissue development#GO:0014706;developmental process#GO:0032502;regulation of system process#GO:0044057;muscle organ development#GO:0007517;cell development#GO:0048468;muscle structure development#GO:0061061;cell differentiation#GO:0030154;regulation of biological process#GO:0050789;muscle cell differentiation#GO:0042692;regulation of muscle system process#GO:0090257;muscle cell development#GO:0055001;neuron development#GO:0048666;muscle tissue development#GO:0060537;system development#GO:0048731;anatomical structure development#GO:0048856;generation of neurons#GO:0048699;skeletal muscle organ development#GO:0060538;animal gross anatomical part developmental process#GO:0160108 sarcolemma#GO:0042383;cell junction#GO:0030054;cell projection#GO:0042995;plasma membrane#GO:0005886;synapse#GO:0045202;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;dystrophin-associated glycoprotein complex#GO:0016010;membrane#GO:0016020;membrane protein complex#GO:0098796 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=31394|UniProtKB=Q6P1K8 Q6P1K8 GTF2H2C PTHR12695:SF2 GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2 GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2-RELATED nucleic acid biosynthetic process#GO:0141187;cellular response to stress#GO:0033554;RNA metabolic process#GO:0016070;cellular response to stimulus#GO:0051716;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;DNA-templated transcription initiation#GO:0006352;response to stimulus#GO:0050896;transcription by RNA polymerase II#GO:0006366;DNA damage response#GO:0006974;nucleobase-containing compound biosynthetic process#GO:0034654;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;response to stress#GO:0006950;transcription initiation at RNA polymerase II promoter#GO:0006367;nucleotide-excision repair#GO:0006289;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467 nuclear protein-containing complex#GO:0140513;protein kinase complex#GO:1902911;intracellular protein-containing complex#GO:0140535;transcription regulator complex#GO:0005667;transcription factor TFIIH core complex#GO:0000439;transferase complex#GO:1990234;protein-containing complex#GO:0032991;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;membrane-enclosed lumen#GO:0031974;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;RNA polymerase II, holoenzyme#GO:0016591;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;transcription factor TFIIH holo complex#GO:0005675;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029 general transcription factor#PC00259;RNA metabolism protein#PC00031 HUMAN|HGNC=11013|UniProtKB=Q9BRI3 Q9BRI3 SLC30A2 PTHR11562:SF51 CATION EFFLUX PROTEIN/ ZINC TRANSPORTER PROTON-COUPLED ZINC ANTIPORTER SLC30A2 monoatomic cation transmembrane transporter activity#GO:0008324;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;transition metal ion transmembrane transporter activity#GO:0046915;zinc ion transmembrane transporter activity#GO:0005385 metal ion transport#GO:0030001;response to stimulus#GO:0050896;transition metal ion transport#GO:0000041;zinc ion transmembrane transport#GO:0071577;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;zinc ion transport#GO:0006829;monoatomic cation transmembrane transport#GO:0098655;response to chemical#GO:0042221;transport#GO:0006810;response to metal ion#GO:0010038;establishment of localization#GO:0051234 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227 HUMAN|HGNC=18790|UniProtKB=P42857 P42857 NSG1 PTHR28546:SF3 NEURONAL VESICLE TRAFFICKING-ASSOCIATED PROTEIN 2-RELATED NEURONAL VESICLE TRAFFICKING-ASSOCIATED PROTEIN 1 binding#GO:0005488;signaling receptor binding#GO:0005102;protein binding#GO:0005515 transport#GO:0006810;regulation of postsynaptic membrane neurotransmitter receptor levels#GO:0099072;metabolic process#GO:0008152;regulation of biological quality#GO:0065008;protein transport#GO:0015031;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;cellular localization#GO:0051641;macromolecule metabolic process#GO:0043170;localization#GO:0051179;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;macromolecule localization#GO:0033036;biological regulation#GO:0065007 somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;cytoplasm#GO:0005737;plasma membrane region#GO:0098590;endomembrane system#GO:0012505;late endosome#GO:0005770;glutamatergic synapse#GO:0098978;neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020;cell junction#GO:0030054;synaptic membrane#GO:0097060;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;synapse#GO:0045202;vesicle#GO:0031982;intracellular vesicle#GO:0097708;postsynapse#GO:0098794;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;dendritic tree#GO:0097447;endosome#GO:0005768;dendrite#GO:0030425;postsynaptic membrane#GO:0045211 HUMAN|HGNC=29676|UniProtKB=Q15397 Q15397 PUM3 PTHR13389:SF0 PUMILIO HOMOLOG 3 PUMILIO HOMOLOG 3 mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;post-transcriptional regulation of gene expression#GO:0010608;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634 HUMAN|HGNC=14582|UniProtKB=Q9UQV4 Q9UQV4 LAMP3 PTHR11506:SF30 LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN 3 localization#GO:0051179;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;establishment of protein localization#GO:0045184 lytic vacuole membrane#GO:0098852;intracellular vesicle#GO:0097708;lysosome#GO:0005764;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;endosome#GO:0005768;endosome membrane#GO:0010008;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;vesicle membrane#GO:0012506;cell periphery#GO:0071944;lysosomal membrane#GO:0005765;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;late endosome#GO:0005770;cytoplasm#GO:0005737;plasma membrane#GO:0005886;vacuole#GO:0005773;late endosome membrane#GO:0031902;vacuolar membrane#GO:0005774;lytic vacuole#GO:0000323;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090 membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=30204|UniProtKB=Q9H0W9 Q9H0W9 BKGD PTHR13204:SF1 PTD012 PROTEIN BETA-KETO L-GULONATE DECARBOXYLASE metal ion binding#GO:0046872;hydrolase activity#GO:0016787;cation binding#GO:0043169;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;transition metal ion binding#GO:0046914;catalytic activity#GO:0003824;zinc ion binding#GO:0008270;hydrolase activity, acting on ester bonds#GO:0016788 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=51815|UniProtKB=A0A1W2PPM1 A0A1W2PPM1 CPHXL PTHR24341:SF1 HOMEOBOX PROTEIN ENGRAILED CYTOPLASMIC POLYADENYLATED HOMEOBOX-LIKE PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;multicellular organism development#GO:0007275;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;developmental process#GO:0032502;neuron differentiation#GO:0030182;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;nervous system development#GO:0007399;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119 HUMAN|HGNC=26228|UniProtKB=Q8N6Q8 Q8N6Q8 METTL25 PTHR12496:SF9 CGI-41 METHYLTRANSFERASE METHYLTRANSFERASE-LIKE PROTEIN 25-RELATED RNA methyltransferase#PC00033 HUMAN|HGNC=27364|UniProtKB=A8MVW5 A8MVW5 HEPACAM2 PTHR44888:SF1 HEPACAM FAMILY MEMBER 2-RELATED HEPACAM FAMILY MEMBER 2 cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;cell cycle#GO:0007049;organelle organization#GO:0006996;cell cycle process#GO:0022402;cellular process#GO:0009987;centrosome cycle#GO:0007098;microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;microtubule organizing center organization#GO:0031023 midbody#GO:0030496;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;microtubule cytoskeleton#GO:0015630;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;endomembrane system#GO:0012505;cytoskeleton#GO:0005856;Golgi apparatus#GO:0005794;spindle#GO:0005819;centrosome#GO:0005813;microtubule organizing center#GO:0005815;membraneless organelle#GO:0043228 HUMAN|HGNC=26041|UniProtKB=Q9NX01 Q9NX01 TXNL4B PTHR12052:SF4 THIOREDOXIN-LIKE PROTEN 4A, 4B THIOREDOXIN-LIKE PROTEIN 4B gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187 nuclear protein-containing complex#GO:0140513;U5 snRNP#GO:0005682;Sm-like protein family complex#GO:0120114;nucleus#GO:0005634;small nuclear ribonucleoprotein complex#GO:0030532;U4/U6 x U5 tri-snRNP complex#GO:0046540;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;spliceosomal tri-snRNP complex#GO:0097526;ribonucleoprotein complex#GO:1990904;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;spliceosomal snRNP complex#GO:0097525;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 oxidoreductase#PC00176 HUMAN|HGNC=18064|UniProtKB=Q9H2S5 Q9H2S5 RNF39 PTHR24103:SF646 E3 UBIQUITIN-PROTEIN LIGASE TRIM RING FINGER PROTEIN 39 ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 defense response to other organism#GO:0098542;response to stimulus#GO:0050896;response to other organism#GO:0051707;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;defense response to symbiont#GO:0140546;immune response#GO:0006955;innate immune response#GO:0045087;defense response#GO:0006952;response to external stimulus#GO:0009605;immune system process#GO:0002376 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=1795|UniProtKB=Q16878 Q16878 CDO1 PTHR12918:SF1 CYSTEINE DIOXYGENASE CYSTEINE DIOXYGENASE TYPE 1 ferrous iron binding#GO:0008198;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;iron ion binding#GO:0005506;transition metal ion binding#GO:0046914;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;cation binding#GO:0043169;oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen#GO:0016702;dioxygenase activity#GO:0051213;metal ion binding#GO:0046872 sulfur compound catabolic process#GO:0044273;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;proteinogenic amino acid metabolic process#GO:0170039;amino acid metabolic process#GO:0006520;small molecule catabolic process#GO:0044282;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;sulfur compound metabolic process#GO:0006790;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987 oxidoreductase#PC00176;oxygenase#PC00177 HUMAN|HGNC=16041|UniProtKB=Q9ULC0 Q9ULC0 EMCN PTHR15869:SF0 ENDOMUCIN-RELATED ENDOMUCIN negative regulation of cellular process#GO:0048523;regulation of leukocyte cell-cell adhesion#GO:1903037;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cell adhesion#GO:0030155;regulation of cell-cell adhesion#GO:0022407;negative regulation of cell-cell adhesion#GO:0022408;negative regulation of cell adhesion#GO:0007162;negative regulation of leukocyte cell-cell adhesion#GO:1903038;biological regulation#GO:0065007 cell surface#GO:0009986;cellular anatomical structure#GO:0110165;external encapsulating structure#GO:0030312;extracellular region#GO:0005576 HUMAN|HGNC=24229|UniProtKB=Q96AQ7 Q96AQ7 CIDEC PTHR12306:SF9 CELL DEATH ACTIVATOR CIDE LIPID TRANSFERASE CIDEC lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104;transporter activity#GO:0005215;lipid transfer activity#GO:0120013 organelle fusion#GO:0048284;organelle organization#GO:0006996;programmed cell death#GO:0012501;cellular component organization#GO:0016043;lipid storage#GO:0019915;cellular process#GO:0009987;apoptotic process#GO:0006915;cell death#GO:0008219;cellular component organization or biogenesis#GO:0071840;lipid droplet organization#GO:0034389 intracellular anatomical structure#GO:0005622;intracellular membraneless organelle#GO:0043232;lipid droplet#GO:0005811;cellular anatomical structure#GO:0110165;membraneless organelle#GO:0043228;organelle#GO:0043226;intracellular organelle#GO:0043229 HUMAN|HGNC=12623|UniProtKB=Q9UPU5 Q9UPU5 USP24 PTHR24006:SF729 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 24 hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;cysteine-type peptidase activity#GO:0008234;cysteine-type deubiquitinase activity#GO:0004843;catalytic activity#GO:0003824 regulation of biological quality#GO:0065008;biological regulation#GO:0065007;regulation of protein stability#GO:0031647 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;cytosol#GO:0005829 cysteine protease#PC00081;protease#PC00190 HUMAN|HGNC=18337|UniProtKB=Q9ULW8 Q9ULW8 PADI3 PTHR10837:SF21 PEPTIDYLARGININE DEIMINASE PROTEIN-ARGININE DEIMINASE TYPE-3 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity#GO:0016787;catalytic activity#GO:0003824 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=4544|UniProtKB=P34947 P34947 GRK5 PTHR24355:SF27 G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE G PROTEIN-COUPLED RECEPTOR KINASE 5 catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 regulation of biological process#GO:0050789;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 Angiotensin II-stimulated signaling through G proteins and beta-arrestin#P05911>GRK5#P05940;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GPRK#P00701;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GPRK#P00741 HUMAN|HGNC=14703|UniProtKB=Q9Y5P1 Q9Y5P1 OR51B2 PTHR26450:SF164 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 51B2 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=10845|UniProtKB=Q6ZVN7 Q6ZVN7 SEM1 PTHR16771:SF14 26 PROTEASOME COMPLEX SUBUNIT DSS1 PROTEIN SEM1, ISOFORM 2-RELATED response to stimulus#GO:0050896;double-strand break repair via homologous recombination#GO:0000724;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular response to stress#GO:0033554;recombinational repair#GO:0000725;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;response to stress#GO:0006950;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;DNA recombination#GO:0006310;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259 intracellular protein-containing complex#GO:0140535;peptidase complex#GO:1905368;protein-containing complex#GO:0032991;proteasome complex#GO:0000502;endopeptidase complex#GO:1905369;catalytic complex#GO:1902494 protein modifying enzyme#PC00260;protease#PC00190 HUMAN|HGNC=2052|UniProtKB=O75596 O75596 CLEC3A PTHR22799:SF2 TETRANECTIN-RELATED C-TYPE LECTIN DOMAIN FAMILY 3 MEMBER A multicellular organismal process#GO:0032501;ossification#GO:0001503 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HUMAN|HGNC=21655|UniProtKB=Q5SY68 Q5SY68 S100A7L2 PTHR11639:SF67 S100 CALCIUM-BINDING PROTEIN PROTEIN S100-A7-LIKE 2 metal ion binding#GO:0046872;protein binding#GO:0005515;cation binding#GO:0043169;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;calcium ion binding#GO:0005509 cell motility#GO:0048870;endothelial cell migration#GO:0043542;cell migration#GO:0016477;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 calmodulin-related#PC00061;calcium-binding protein#PC00060 HUMAN|HGNC=17751|UniProtKB=Q6Q6R5 Q6Q6R5 CRIP3 PTHR46074:SF4 CYSTEINE-RICH PROTEIN CRIP FAMILY MEMBER CYSTEINE-RICH PROTEIN 3 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=24039|UniProtKB=Q9H6B4 Q9H6B4 CLMP PTHR44783:SF1 CXADR-LIKE MEMBRANE PROTEIN CXADR-LIKE MEMBRANE PROTEIN HUMAN|HGNC=5391|UniProtKB=P35475 P35475 IDUA PTHR12631:SF8 ALPHA-L-IDURONIDASE ALPHA-L-IDURONIDASE hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 glycosidase#PC00110;hydrolase#PC00121 HUMAN|HGNC=16435|UniProtKB=Q8TCT9 Q8TCT9 HM13 PTHR12174:SF23 SIGNAL PEPTIDE PEPTIDASE SIGNAL PEPTIDE PEPTIDASE catalytic activity#GO:0003824;aspartic-type endopeptidase activity#GO:0004190;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175 biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467;membrane protein proteolysis#GO:0033619;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;proteolysis#GO:0006508;metabolic process#GO:0008152 organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;cytoplasmic side of membrane#GO:0098562;cytoplasmic side of endoplasmic reticulum membrane#GO:0098554;endomembrane system#GO:0012505;cytoplasm#GO:0005737;membrane#GO:0016020;side of membrane#GO:0098552;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 aspartic protease#PC00053;protein modifying enzyme#PC00260 HUMAN|HGNC=29066|UniProtKB=Q9UKJ3 Q9UKJ3 GPATCH8 PTHR17614:SF11 ZINC FINGER-CONTAINING G PATCH DOMAIN-CONTAINING PROTEIN 8 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=8773|UniProtKB=Q9HCR9 Q9HCR9 PDE11A PTHR11347:SF130 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE DUAL 3',5'-CYCLIC-AMP AND -GMP PHOSPHODIESTERASE 11A phosphoric ester hydrolase activity#GO:0042578;phosphoric diester hydrolase activity#GO:0008081;hydrolase activity#GO:0016787;cyclic-nucleotide phosphodiesterase activity#GO:0004112;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788 negative regulation of response to stimulus#GO:0048585;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;negative regulation of signal transduction#GO:0009968;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;regulation of intracellular signal transduction#GO:1902531;negative regulation of cellular process#GO:0048523;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583 hydrolase#PC00121;phosphodiesterase#PC00185 HUMAN|HGNC=26783|UniProtKB=Q96GF1 Q96GF1 RNF185 PTHR12313:SF13 E3 UBIQUITIN-PROTEIN LIGASE RNF5-RELATED E3 UBIQUITIN-PROTEIN LIGASE RNF185 response to chemical#GO:0042221;proteasomal protein catabolic process#GO:0010498;response to stress#GO:0006950;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;response to stimulus#GO:0050896;catabolic process#GO:0009056;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;protein metabolic process#GO:0019538;ERAD pathway#GO:0036503;response to endoplasmic reticulum stress#GO:0034976;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=18540|UniProtKB=Q8TCG5 Q8TCG5 CPT1C PTHR22589:SF55 CARNITINE O-ACYLTRANSFERASE PALMITOYL THIOESTERASE CPT1C acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;palmitoyltransferase activity#GO:0016409 monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;modified amino acid metabolic process#GO:0006575;carboxylic acid metabolic process#GO:0019752;carnitine metabolic process#GO:0009437;cellular process#GO:0009987;small molecule metabolic process#GO:0044281;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;fatty acid metabolic process#GO:0006631;lipid metabolic process#GO:0006629 endomembrane system#GO:0012505;cytoplasm#GO:0005737;membrane#GO:0016020;organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229 metabolite interconversion enzyme#PC00262;acyltransferase#PC00042 HUMAN|HGNC=11321|UniProtKB=O43805 O43805 SSNA1 PTHR28661:SF3 SJOEGREN SYNDROME NUCLEAR AUTOANTIGEN 1 MICROTUBULE NUCLEATION FACTOR SSNA1 neuron projection extension#GO:1990138;axonogenesis#GO:0007409;neuron development#GO:0048666;developmental growth involved in morphogenesis#GO:0060560;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell morphogenesis#GO:0000902;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;cell projection morphogenesis#GO:0048858;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cell growth#GO:0016049;neuron differentiation#GO:0030182;growth#GO:0040007;plasma membrane bounded cell projection morphogenesis#GO:0120039;axon extension#GO:0048675;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;cellular process#GO:0009987;neuron projection development#GO:0031175;system development#GO:0048731;anatomical structure development#GO:0048856;developmental cell growth#GO:0048588;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;developmental growth#GO:0048589;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;plasma membrane bounded cell projection organization#GO:0120036;multicellular organismal process#GO:0032501;axon development#GO:0061564 neuron projection#GO:0043005;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;centrosome#GO:0005813;membraneless organelle#GO:0043228;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cilium#GO:0005929;intracellular organelle#GO:0043229;axon#GO:0030424;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=14799|UniProtKB=Q8NH60 Q8NH60 OR52J3 PTHR26450:SF355 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 52J3 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=31256|UniProtKB=Q8NGX1 Q8NGX1 OR2T34 PTHR26453:SF4 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2T3-RELATED molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 detection of chemical stimulus#GO:0009593;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;response to chemical#GO:0042221;response to stimulus#GO:0050896;nervous system process#GO:0050877;sensory perception#GO:0007600;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;system process#GO:0003008 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=26056|UniProtKB=Q9NWW7 Q9NWW7 C2orf42 PTHR13518:SF1 PUTATIVE TREBLE-CLEF ZINC-FINGER C2ORF42 FAMILY MEMBER RGD1306746 PROTEIN nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=8602|UniProtKB=Q13219 Q13219 PAPPA PTHR46130:SF2 LAMGL DOMAIN-CONTAINING PROTEIN PAPPALYSIN-1 metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 cellular process#GO:0009987;metabolic process#GO:0008152;proteolysis#GO:0006508;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=5341|UniProtKB=P21815 P21815 IBSP PTHR10345:SF0 BONE SIALOPROTEIN 2 INTEGRIN-BINDING SIALOPROTEIN structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 cellular process#GO:0009987;cellular component organization#GO:0016043;multicellular organismal process#GO:0032501;ossification#GO:0001503;tissue development#GO:0009888;biomineral tissue development#GO:0031214;developmental process#GO:0032502;extracellular structure organization#GO:0043062;animal gross anatomical part developmental process#GO:0160108;bone mineralization#GO:0030282;external encapsulating structure organization#GO:0045229;anatomical structure development#GO:0048856;animal organ development#GO:0048513;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 extracellular matrix structural protein#PC00103 HUMAN|HGNC=13749|UniProtKB=P98173 P98173 FAM3A PTHR14592:SF11 UNCHARACTERIZED FAM3 PROTEIN FAM3A signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;cytokine activity#GO:0005125 cell communication#GO:0007154;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 antimicrobial response protein#PC00051;defense/immunity protein#PC00090 HUMAN|HGNC=4252|UniProtKB=A6NGU5 A6NGU5 GGT3P PTHR11686:SF56 GAMMA GLUTAMYL TRANSPEPTIDASE GLUTATHIONE HYDROLASE 1 PROENZYME-RELATED catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233 sulfur compound catabolic process#GO:0044273;regulation of response to stimulus#GO:0048583;regulation of response to stress#GO:0080134;metabolic process#GO:0008152;biological regulation#GO:0065007;regulation of response to external stimulus#GO:0032101;cellular process#GO:0009987;sulfur compound metabolic process#GO:0006790;peptide metabolic process#GO:0006518;regulation of inflammatory response#GO:0050727;regulation of defense response#GO:0031347;glutathione metabolic process#GO:0006749;regulation of immune system process#GO:0002682;catabolic process#GO:0009056;regulation of biological process#GO:0050789;modified amino acid metabolic process#GO:0006575 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 protein modifying enzyme#PC00260;protease#PC00190 HUMAN|HGNC=16807|UniProtKB=Q9HCE7 Q9HCE7 SMURF1 PTHR11254:SF293 HECT DOMAIN UBIQUITIN-PROTEIN LIGASE E3 UBIQUITIN-PROTEIN LIGASE SMURF1 ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;binding#GO:0005488;acyltransferase activity#GO:0016746;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;protein binding#GO:0005515;catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 negative regulation of BMP signaling pathway#GO:0030514;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;regulation of response to stimulus#GO:0048583;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cellular response to growth factor stimulus#GO:0090287;negative regulation of signal transduction#GO:0009968;proteasomal protein catabolic process#GO:0010498;negative regulation of response to stimulus#GO:0048585;cellular process#GO:0009987;regulation of BMP signaling pathway#GO:0030510;negative regulation of cell communication#GO:0010648;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;regulation of signaling#GO:0023051;modification-dependent macromolecule catabolic process#GO:0043632;negative regulation of signaling#GO:0023057;regulation of cell communication#GO:0010646;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;modification-dependent protein catabolic process#GO:0019941;regulation of biological process#GO:0050789;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092;negative regulation of biological process#GO:0048519;primary metabolic process#GO:0044238 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 Ubiquitin proteasome pathway#P00060>E3#P01490;TGF-beta signaling pathway#P00052>Smurfs#P01279 HUMAN|HGNC=20465|UniProtKB=Q8IY18 Q8IY18 SMC5 PTHR45916:SF1 STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5 STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5 DNA binding#GO:0003677;nucleic acid binding#GO:0003676;binding#GO:0005488;single-stranded DNA binding#GO:0003697 macromolecule metabolic process#GO:0043170;double-strand break repair#GO:0006302;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;DNA recombination#GO:0006310;DNA damage response#GO:0006974;nucleobase-containing compound metabolic process#GO:0006139;response to stress#GO:0006950;cellular process#GO:0009987;recombinational repair#GO:0000725;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;double-strand break repair via homologous recombination#GO:0000724;cellular response to stimulus#GO:0051716 intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634;chromosome#GO:0005694;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;condensed chromosome#GO:0000793 HUMAN|HGNC=4095|UniProtKB=P24522 P24522 GADD45A PTHR10411:SF3 GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA protein sequestering activity#GO:0140311;molecular sequestering activity#GO:0140313 regulation of response to stimulus#GO:0048583;regulation of MAPK cascade#GO:0043408;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of MAPK cascade#GO:0043410;regulation of JNK cascade#GO:0046328;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;positive regulation of JNK cascade#GO:0046330;positive regulation of signaling#GO:0023056;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;regulation of cell cycle#GO:0051726;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 p53 pathway#P00059>GADD45#G01575;PI3 kinase pathway#P00048>GADD45#G01544;p38 MAPK pathway#P05918>GADD45#P06044;p53 pathway#P00059>GADD45#P04626 HUMAN|HGNC=11174|UniProtKB=O60493 O60493 SNX3 PTHR45963:SF1 RE52028P SORTING NEXIN-3 phosphatidylinositol phosphate binding#GO:1901981;phosphatidylinositol-3-phosphate binding#GO:0032266;lipid binding#GO:0008289;phospholipid binding#GO:0005543;binding#GO:0005488 cytosolic transport#GO:0016482;endocytic recycling#GO:0032456;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;retrograde transport, endosome to Golgi#GO:0042147;endosomal transport#GO:0016197;vesicle-mediated transport to the plasma membrane#GO:0098876;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization within membrane#GO:0051668;transport#GO:0006810;Golgi vesicle transport#GO:0048193;intracellular transport#GO:0046907 endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;vesicle membrane#GO:0012506;membrane#GO:0016020;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;early endosome membrane#GO:0031901;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768;endosome membrane#GO:0010008 HUMAN|HGNC=20324|UniProtKB=O95455 O95455 TGDS PTHR43000:SF54 DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED UDP-D-GLUCOSE 4,6-DEHYDRATASE hydro-lyase activity#GO:0016836;carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;catalytic activity#GO:0003824 dehydratase#PC00091 O-antigen biosynthesis#P02757>dTDP-glucose 4,6-dehydratase#P03045 HUMAN|HGNC=7512|UniProtKB=Q02817 Q02817 MUC2 PTHR11339:SF384 EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED MUCIN-2 structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 extracellular matrix protein#PC00102 HUMAN|HGNC=32400|UniProtKB=Q30KP9 Q30KP9 DEFB135 PTHR15001:SF10 BETA-DEFENSIN 123-RELATED BETA-DEFENSIN 135 cell killing#GO:0001906;immune system process#GO:0002376;innate immune response#GO:0045087;defense response#GO:0006952;response to external stimulus#GO:0009605;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;cellular process#GO:0009987;immune response#GO:0006955;defense response to symbiont#GO:0140546;defense response to other organism#GO:0098542;response to stimulus#GO:0050896;response to other organism#GO:0051707;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419 antimicrobial response protein#PC00051;defense/immunity protein#PC00090 HUMAN|HGNC=14807|UniProtKB=Q8NGN2 Q8NGN2 OR10S1 PTHR26453:SF205 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 10S1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;detection of chemical stimulus#GO:0009593;response to stimulus#GO:0050896;response to chemical#GO:0042221;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;sensory perception#GO:0007600;nervous system process#GO:0050877;system process#GO:0003008 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=4333|UniProtKB=Q9NZM5 Q9NZM5 NOP53 PTHR14211:SF8 GLIOMA SUPPRESSOR CANDIDATE REGION GENE 2 RIBOSOME BIOGENESIS PROTEIN NOP53 rRNA binding#GO:0019843;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 ribosome biogenesis#GO:0042254;ribosome assembly#GO:0042255;ribosomal large subunit biogenesis#GO:0042273;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;ribonucleoprotein complex biogenesis#GO:0022613;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;protein-RNA complex organization#GO:0071826;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;gene expression#GO:0010467;cellular component assembly#GO:0022607;RNA processing#GO:0006396;organelle assembly#GO:0070925;protein-RNA complex assembly#GO:0022618;rRNA processing#GO:0006364;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;rRNA metabolic process#GO:0016072;macromolecule metabolic process#GO:0043170;ribosomal large subunit assembly#GO:0000027;macromolecule biosynthetic process#GO:0009059;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139 organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 HUMAN|HGNC=18698|UniProtKB=Q9UHL0 Q9UHL0 DDX25 PTHR47958:SF33 ATP-DEPENDENT RNA HELICASE DBP3 ATP-DEPENDENT RNA HELICASE DDX25 isomerase activity#GO:0016853;catalytic activity, acting on RNA#GO:0140098;helicase activity#GO:0004386;macromolecular conformation isomerase activity#GO:0120543;catalytic activity#GO:0003824;RNA helicase activity#GO:0003724;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;RNA binding#GO:0003723;ATP-dependent activity#GO:0140657;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729 nitrogen compound transport#GO:0071705;macromolecule localization#GO:0033036;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907;metabolic process#GO:0008152;transport#GO:0006810;establishment of localization#GO:0051234;poly(A)+ mRNA export from nucleus#GO:0016973;macromolecule metabolic process#GO:0043170;RNA localization#GO:0006403;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;mRNA transport#GO:0051028;establishment of RNA localization#GO:0051236;nucleocytoplasmic transport#GO:0006913;cellular localization#GO:0051641;mRNA export from nucleus#GO:0006406;nucleic acid transport#GO:0050657;localization#GO:0051179;nuclear export#GO:0051168;nuclear transport#GO:0051169 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoplasmic stress granule#GO:0010494;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;nucleus#GO:0005634 RNA helicase#PC00032 HUMAN|HGNC=27029|UniProtKB=Q6P4H8 Q6P4H8 ATPSCKMT PTHR13610:SF8 METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN ATP SYNTHASE SUBUNIT C LYSINE N-METHYLTRANSFERASE transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring one-carbon groups#GO:0016741;protein methyltransferase activity#GO:0008276;catalytic activity, acting on a protein#GO:0140096;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;protein-lysine N-methyltransferase activity#GO:0016279;N-methyltransferase activity#GO:0008170;lysine N-methyltransferase activity#GO:0016278 regulation of system process#GO:0044057;regulation of biosynthetic process#GO:0009889;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of multicellular organismal process#GO:0051240;regulation of biological process#GO:0050789;positive regulation of biological process#GO:0048518;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007 mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=13028|UniProtKB=Q9UL36 Q9UL36 ZNF236 PTHR24396:SF21 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 236 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218;C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HUMAN|HGNC=6278|UniProtKB=O14649 O14649 KCNK3 PTHR11003:SF138 POTASSIUM CHANNEL, SUBFAMILY K POTASSIUM CHANNEL SUBFAMILY K MEMBER 3 gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;transporter activity#GO:0005215;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;outward rectifier potassium channel activity#GO:0015271;potassium channel activity#GO:0005267;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261 transport#GO:0006810;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;potassium ion transmembrane transport#GO:0071805 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 Dopamine receptor mediated signaling pathway#P05912>K+ channel#P05957;5HT3 type receptor mediated signaling pathway#P04375>K+ channel#P04425;5HT4 type receptor mediated signaling pathway#P04376>K+ channel#P04426;Opioid proenkephalin pathway#P05915>K+ channel#P05990;Nicotine pharmacodynamics pathway#P06587>KCNK3/9#P06605;5HT2 type receptor mediated signaling pathway#P04374>K+ channel#P04413;Opioid proopiomelanocortin pathway#P05917>K+ channel#P06009;5HT1 type receptor mediated signaling pathway#P04373>K+ channel#P04407 HUMAN|HGNC=24649|UniProtKB=Q9HBU6 Q9HBU6 ETNK1 PTHR22603:SF91 CHOLINE/ETHANOALAMINE KINASE ETHANOLAMINE KINASE 1 transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773 organophosphate metabolic process#GO:0019637;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;glycerophospholipid metabolic process#GO:0006650;glycerolipid metabolic process#GO:0046486;lipid biosynthetic process#GO:0008610;phospholipid biosynthetic process#GO:0008654;phospholipid metabolic process#GO:0006644;biosynthetic process#GO:0009058;metabolic process#GO:0008152;glycerophospholipid biosynthetic process#GO:0046474;lipid metabolic process#GO:0006629;organophosphate biosynthetic process#GO:0090407 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 kinase#PC00137 HUMAN|HGNC=226|UniProtKB=P78563 P78563 ADARB1 PTHR10910:SF58 EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN DOUBLE-STRANDED RNA-SPECIFIC EDITASE 1 double-stranded RNA binding#GO:0003725;tRNA-specific adenosine deaminase activity#GO:0008251;nucleic acid binding#GO:0003676;binding#GO:0005488;adenosine deaminase activity#GO:0004000;catalytic activity, acting on a tRNA#GO:0140101;RNA binding#GO:0003723;hydrolase activity#GO:0016787;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;deaminase activity#GO:0019239;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;gene expression#GO:0010467;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;adenosine to inosine editing#GO:0006382;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187;base conversion or substitution editing#GO:0016553;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412 organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031 HUMAN|HGNC=28043|UniProtKB=O75541 O75541 ZNF821 PTHR24404:SF1 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 821 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218 HUMAN|HGNC=2021|UniProtKB=P51790 P51790 CLCN3 PTHR45711:SF8 CHLORIDE CHANNEL PROTEIN H(+)_CL(-) EXCHANGE TRANSPORTER 3 monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic anion transmembrane transporter activity#GO:0008509;chloride transmembrane transporter activity#GO:0015108;passive transmembrane transporter activity#GO:0022803;chloride channel activity#GO:0005254;channel activity#GO:0015267;monoatomic anion channel activity#GO:0005253 inorganic anion transport#GO:0015698;monoatomic ion transport#GO:0006811;chloride transmembrane transport#GO:1902476;monoatomic cation transport#GO:0006812;localization#GO:0051179;cellular localization#GO:0051641;transmembrane transport#GO:0055085;monoatomic anion transport#GO:0006820;cellular component organization#GO:0016043;homeostatic process#GO:0042592;developmental process#GO:0032502;transport#GO:0006810;synaptic vesicle cycle#GO:0099504;chloride transport#GO:0006821;vesicle organization#GO:0016050;cellular homeostasis#GO:0019725;synaptic vesicle maturation#GO:0016188;cellular component organization or biogenesis#GO:0071840;proton transmembrane transport#GO:1902600;establishment of localization#GO:0051234;vesicle-mediated transport in synapse#GO:0099003;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle organization#GO:0006996;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;developmental maturation#GO:0021700;vesicle-mediated transport#GO:0016192;monoatomic anion transmembrane transport#GO:0098656 cell junction#GO:0030054;lytic vacuole#GO:0000323;bounding membrane of organelle#GO:0098588;cytoplasmic vesicle membrane#GO:0030659;vacuole#GO:0005773;cytoplasm#GO:0005737;secretory vesicle#GO:0099503;presynapse#GO:0098793;lysosomal membrane#GO:0005765;intracellular organelle#GO:0043229;endosome#GO:0005768;endosome membrane#GO:0010008;exocytic vesicle#GO:0070382;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;lytic vacuole membrane#GO:0098852;intracellular vesicle#GO:0097708;lysosome#GO:0005764;vacuolar membrane#GO:0005774;organelle membrane#GO:0031090;Golgi apparatus#GO:0005794;transport vesicle#GO:0030133;endomembrane system#GO:0012505;plasma membrane#GO:0005886;vesicle membrane#GO:0012506;membrane#GO:0016020;cell periphery#GO:0071944;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular membrane-bounded organelle#GO:0043231;vesicle#GO:0031982;synaptic vesicle#GO:0008021 transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=31851|UniProtKB=A0A0U1RR11 A0A0U1RR11 CENPVL1 PTHR28620:SF3 CENTROMERE PROTEIN V CENTROMERE PROTEIN V-LIKE PROTEIN 1 HUMAN|HGNC=25365|UniProtKB=Q8WUF8 Q8WUF8 ARB2A PTHR21357:SF3 FAM172 FAMILY PROTEIN HOMOLOG CG10038 COTRANSCRIPTIONAL REGULATOR ARB2A RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 regulatory ncRNA-mediated gene silencing#GO:0031047;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;negative regulation of gene expression, epigenetic#GO:0045814;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;epigenetic regulation of gene expression#GO:0040029;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;heterochromatin organization#GO:0070828;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;chromatin organization#GO:0006325;cellular component assembly#GO:0022607;regulatory ncRNA-mediated heterochromatin formation#GO:0031048;regulation of biological process#GO:0050789;heterochromatin formation#GO:0031507;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=2227|UniProtKB=P49747 P49747 COMP PTHR10199:SF88 THROMBOSPONDIN CARTILAGE OLIGOMERIC MATRIX PROTEIN structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 anatomical structure development#GO:0048856;tissue development#GO:0009888;connective tissue development#GO:0061448;animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502 extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cellular anatomical structure#GO:0110165 cell adhesion molecule#PC00069 HUMAN|HGNC=16683|UniProtKB=Q6GQQ9 Q6GQQ9 OTUD7B PTHR13367:SF8 UBIQUITIN THIOESTERASE OTU DOMAIN-CONTAINING PROTEIN 7B protein binding#GO:0005515;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;modification-dependent protein binding#GO:0140030;binding#GO:0005488;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;polyubiquitin modification-dependent protein binding#GO:0031593;K63-linked polyubiquitin modification-dependent protein binding#GO:0070530;cysteine-type deubiquitinase activity#GO:0004843;cysteine-type peptidase activity#GO:0008234 regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;post-translational protein modification#GO:0043687;negative regulation of response to stimulus#GO:0048585;regulation of canonical NF-kappaB signal transduction#GO:0043122;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;regulation of cell communication#GO:0010646;catabolic process#GO:0009056;negative regulation of canonical NF-kappaB signal transduction#GO:0043124;regulation of cellular process#GO:0050794;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;negative regulation of signal transduction#GO:0009968;cellular process#GO:0009987;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;protein catabolic process#GO:0030163;regulation of signaling#GO:0023051;modification-dependent macromolecule catabolic process#GO:0043632;protein modification by small protein conjugation or removal#GO:0070647;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531 nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 protease#PC00190;cysteine protease#PC00081 HUMAN|HGNC=23596|UniProtKB=Q6L8H4 Q6L8H4 KRTAP5-1 PTHR23262:SF127 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 5-1 structural protein#PC00211 HUMAN|HGNC=368|UniProtKB=O43572 O43572 AKAP10 PTHR13155:SF1 A-KINASE ANCHOR PROTEINS A-KINASE ANCHOR PROTEIN 10, MITOCHONDRIAL protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;protein-membrane adaptor activity#GO:0043495 macromolecule localization#GO:0033036;localization#GO:0051179;intracellular protein localization#GO:0008104 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 scaffold/adaptor protein#PC00226 HUMAN|HGNC=23115|UniProtKB=Q96CJ1 Q96CJ1 EAF2 PTHR15970:SF7 ELL-ASSOCIATED FACTOR EAF ELL-ASSOCIATED FACTOR 2 transcription regulator activity#GO:0140110;transcription elongation factor activity#GO:0003711 transcription elongation by RNA polymerase II#GO:0006368;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;DNA-templated transcription elongation#GO:0006354;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;transcription by RNA polymerase II#GO:0006366;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;protein-containing complex#GO:0032991;transcription elongation factor complex#GO:0008023;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=29577|UniProtKB=Q8WVE7 Q8WVE7 TMEM170A PTHR22779:SF2 SD17342P TRANSMEMBRANE PROTEIN 170A endomembrane system organization#GO:0010256;endoplasmic reticulum tubular network organization#GO:0071786;cellular component organization or biogenesis#GO:0071840;endoplasmic reticulum organization#GO:0007029;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996 membrane#GO:0016020;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=9237|UniProtKB=Q9UBK2 Q9UBK2 PPARGC1A PTHR15528:SF10 PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1 PGC-1 -RELATED PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA COACTIVATOR 1-ALPHA transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;transcription coactivator activity#GO:0003713 regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of RNA metabolic process#GO:0051254;homeostatic process#GO:0042592;regulation of DNA-templated transcription#GO:0006355;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of RNA metabolic process#GO:0051252;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of DNA-templated transcription#GO:0045893;multicellular organismal process#GO:0032501;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;multicellular organismal-level homeostasis#GO:0048871 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 transcription cofactor#PC00217;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=5829|UniProtKB=A0A0C4DH55 A0A0C4DH55 IGKV3D-7 PTHR23267:SF331 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN KAPPA VARIABLE 3-15-RELATED immune response#GO:0006955;immune system process#GO:0002376;response to stimulus#GO:0050896 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=3257|UniProtKB=Q14232 Q14232 EIF2B1 PTHR45860:SF1 TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA TRANSLATION INITIATION FACTOR EIF2B SUBUNIT ALPHA translation initiation factor#PC00224 HUMAN|HGNC=582|UniProtKB=Q92870 Q92870 APBB2 PTHR14058:SF11 AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B AMYLOID BETA PRECURSOR PROTEIN BINDING FAMILY B MEMBER 2 binding#GO:0005488;peptide binding#GO:0042277 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 Alzheimer disease-presenilin pathway#P00004>Fe65#P00126 HUMAN|HGNC=16462|UniProtKB=Q96SI9 Q96SI9 STRBP PTHR45762:SF1 ZINC FINGER RNA-BINDING PROTEIN SPERMATID PERINUCLEAR RNA-BINDING PROTEIN binding#GO:0005488;nucleic acid binding#GO:0003676;double-stranded RNA binding#GO:0003725;RNA binding#GO:0003723;single-stranded RNA binding#GO:0003727 RNA metabolism protein#PC00031 HUMAN|HGNC=25529|UniProtKB=Q6RFH5 Q6RFH5 WDR74 PTHR16038:SF4 NOP SEVEN ASSOCIATED PROTEIN 1 WD REPEAT-CONTAINING PROTEIN 74 RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;ribosome biogenesis#GO:0042254;ribosomal large subunit biogenesis#GO:0042273;nucleic acid biosynthetic process#GO:0141187;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;gene expression#GO:0010467;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 membraneless organelle#GO:0043228;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;preribosome#GO:0030684;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;preribosome, large subunit precursor#GO:0030687;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226 RNA processing factor#PC00147 HUMAN|HGNC=26740|UniProtKB=Q53RD9 Q53RD9 FBLN7 PTHR24034:SF94 EGF-LIKE DOMAIN-CONTAINING PROTEIN FIBULIN-7 extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cellular anatomical structure#GO:0110165 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HUMAN|HGNC=30139|UniProtKB=O60299 O60299 LZTS3 PTHR19354:SF6 ZIPPER PUTATIVE TUMOR SUPPRESSOR 2 HOMOLOG-LIKE PROTEIN-RELATED ZIPPER PUTATIVE TUMOR SUPPRESSOR 3-RELATED regulation of biological quality#GO:0065008;regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of anatomical structure morphogenesis#GO:0022603;regulation of synapse structure or activity#GO:0050803;regulation of dendritic spine morphogenesis#GO:0061001;regulation of synapse organization#GO:0050807;regulation of cell projection organization#GO:0031344;biological regulation#GO:0065007;regulation of developmental process#GO:0050793;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of neuron projection development#GO:0010975;regulation of biological process#GO:0050789;regulation of postsynapse organization#GO:0099175 synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;somatodendritic compartment#GO:0036477;neuron spine#GO:0044309;plasma membrane bounded cell projection#GO:0120025;postsynapse#GO:0098794;neuron projection#GO:0043005;dendritic spine#GO:0043197;cell junction#GO:0030054;dendrite#GO:0030425;dendritic tree#GO:0097447 HUMAN|HGNC=1918|UniProtKB=Q12873 Q12873 CHD3 PTHR45623:SF9 CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED ATP-DEPENDENT CHROMATIN REMODELER CHD3 catalytic activity, acting on DNA#GO:0140097;hydrolase activity, acting on acid anhydrides#GO:0016817;ATP-dependent activity, acting on DNA#GO:0008094;protein binding#GO:0005515;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;ATP-dependent activity#GO:0140657;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;histone binding#GO:0042393;hydrolase activity#GO:0016787;DNA binding#GO:0003677;ATP hydrolysis activity#GO:0016887;nucleic acid binding#GO:0003676;chromatin binding#GO:0003682 cellular process#GO:0009987;cellular component organization#GO:0016043;chromatin remodeling#GO:0006338;chromatin organization#GO:0006325;cellular component organization or biogenesis#GO:0071840 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=24114|UniProtKB=Q9NWT8 Q9NWT8 AURKAIP1 PTHR32035:SF3 AURORA KINASE A-INTERACTING PROTEIN SMALL RIBOSOMAL SUBUNIT PROTEIN BS22, MITOCHONDRIAL HUMAN|HGNC=17567|UniProtKB=Q6UYE1 Q6UYE1 DLEU7 PTHR36961:SF1 LEUKEMIA-ASSOCIATED PROTEIN 7 LEUKEMIA-ASSOCIATED PROTEIN 7 HUMAN|HGNC=18399|UniProtKB=Q8N5I4 Q8N5I4 DHRSX PTHR24320:SF264 RETINOL DEHYDROGENASE POLYPRENOL DEHYDROGENASE oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;alcohol dehydrogenase (NADP+) activity#GO:0008106;oxidoreductase activity#GO:0016491;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824 organophosphate biosynthetic process#GO:0090407;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;lipid biosynthetic process#GO:0008610;phospholipid biosynthetic process#GO:0008654;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793 membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020 oxidoreductase#PC00176;dehydrogenase#PC00092 HUMAN|HGNC=4609|UniProtKB=P30550 P30550 GRPR PTHR45695:SF7 LEUCOKININ RECEPTOR-RELATED GASTRIN-RELEASING PEPTIDE RECEPTOR G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888;neuropeptide receptor activity#GO:0008188;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=4251|UniProtKB=P36268 P36268 GGT2P PTHR11686:SF56 GAMMA GLUTAMYL TRANSPEPTIDASE GLUTATHIONE HYDROLASE 1 PROENZYME-RELATED hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;catalytic activity#GO:0003824 peptide metabolic process#GO:0006518;glutathione metabolic process#GO:0006749;regulation of defense response#GO:0031347;regulation of inflammatory response#GO:0050727;regulation of immune system process#GO:0002682;catabolic process#GO:0009056;modified amino acid metabolic process#GO:0006575;regulation of biological process#GO:0050789;sulfur compound catabolic process#GO:0044273;regulation of response to stress#GO:0080134;metabolic process#GO:0008152;regulation of response to stimulus#GO:0048583;regulation of response to external stimulus#GO:0032101;biological regulation#GO:0065007;sulfur compound metabolic process#GO:0006790;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 protein modifying enzyme#PC00260;protease#PC00190 HUMAN|HGNC=4599|UniProtKB=Q14831 Q14831 GRM7 PTHR24060:SF98 METABOTROPIC GLUTAMATE RECEPTOR METABOTROPIC GLUTAMATE RECEPTOR 7 transmembrane signaling receptor activity#GO:0004888;glutamate receptor activity#GO:0008066;adenylate cyclase inhibiting G protein-coupled glutamate receptor activity#GO:0001640;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930 biological regulation#GO:0065007;regulation of trans-synaptic signaling#GO:0099177;signal transduction#GO:0007165;cellular process#GO:0009987;cell surface receptor signaling pathway#GO:0007166;signaling#GO:0023052;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;glutamate receptor signaling pathway#GO:0007215;cell communication#GO:0007154;regulation of synaptic transmission, glutamatergic#GO:0051966;regulation of signaling#GO:0023051;G protein-coupled receptor signaling pathway#GO:0007186 G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GqPCR#P00730;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;Metabotropic glutamate receptor group III pathway#P00039>mGluR4/6/7/8#P01044;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GoPCR#P00725 HUMAN|HGNC=25999|UniProtKB=Q9NXD2 Q9NXD2 MTMR10 PTHR10807:SF39 MYOTUBULARIN-RELATED MYOTUBULARIN-RELATED PROTEIN 10 phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578 dephosphorylation#GO:0016311;lipid modification#GO:0030258;phosphatidylinositol metabolic process#GO:0046488;lipid metabolic process#GO:0006629;phosphatidylinositol dephosphorylation#GO:0046856;metabolic process#GO:0008152;phospholipid metabolic process#GO:0006644;glycerophospholipid metabolic process#GO:0006650;glycerolipid metabolic process#GO:0046486;phosphate-containing compound metabolic process#GO:0006796;cellular process#GO:0009987;phospholipid dephosphorylation#GO:0046839;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;organophosphate metabolic process#GO:0019637 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;membrane#GO:0016020 phosphatase#PC00181 HUMAN|HGNC=21027|UniProtKB=Q8NFD2 Q8NFD2 ANKK1 PTHR24198:SF175 ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN 1 regulation of biological process#GO:0050789;regulation of cell cycle#GO:0051726;regulation of cell cycle process#GO:0010564;biological regulation#GO:0065007;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=2018|UniProtKB=Q14CN2 Q14CN2 CLCA4 PTHR10579:SF2 CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR 4 ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;monoatomic anion channel activity#GO:0005253;channel activity#GO:0015267;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;chloride transmembrane transporter activity#GO:0015108;chloride channel activity#GO:0005254;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic anion transmembrane transporter activity#GO:0008509;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133 HUMAN|HGNC=3166|UniProtKB=Q92633 Q92633 LPAR1 PTHR22750:SF22 G-PROTEIN COUPLED RECEPTOR LYSOPHOSPHATIDIC ACID RECEPTOR 1 bioactive lipid receptor activity#GO:0045125;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023 animal gross anatomical part developmental process#GO:0160108;G protein-coupled receptor signaling pathway#GO:0007186;system development#GO:0048731;anatomical structure development#GO:0048856;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signaling#GO:0023052;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;response to stimulus#GO:0050896;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;developmental process#GO:0032502;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;cellular process#GO:0009987;signal transduction#GO:0007165;nervous system development#GO:0007399;biological regulation#GO:0065007;multicellular organismal process#GO:0032501 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021 HUMAN|HGNC=14752|UniProtKB=Q8NGV7 Q8NGV7 OR5H2 PTHR26452:SF836 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5H2 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 sensory perception of chemical stimulus#GO:0007606;sensory perception#GO:0007600;nervous system process#GO:0050877;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;system process#GO:0003008 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=24844|UniProtKB=Q8N7S2 Q8N7S2 DNAJC5G PTHR44027:SF2 DNAJ HOMOLOG SUBFAMILY C MEMBER 5 HOMOLOG DNAJ HOMOLOG SUBFAMILY C MEMBER 5G chaperone#PC00072 HUMAN|HGNC=30233|UniProtKB=Q5T9Z0 Q5T9Z0 TEDDM1 PTHR46441:SF2 TRANSMEMBRANE EPIDIDYMAL FAMILY MEMBER 3 TRANSMEMBRANE EPIDIDYMAL PROTEIN 1 HUMAN|HGNC=15267|UniProtKB=Q8NGF7 Q8NGF7 OR5B17 PTHR48018:SF25 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5B17 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;sensory perception of smell#GO:0007608;sensory perception#GO:0007600;nervous system process#GO:0050877;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=17905|UniProtKB=Q9Y613 Q9Y613 FHOD1 PTHR45920:SF2 FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I FH1_FH2 DOMAIN-CONTAINING PROTEIN 1 protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;actin binding#GO:0003779;actin filament binding#GO:0051015;cytoskeletal protein binding#GO:0008092 actin filament-based process#GO:0030029;positive regulation of cellular component organization#GO:0051130;positive regulation of organelle organization#GO:0010638;supramolecular fiber organization#GO:0097435;cellular component organization#GO:0016043;regulation of actin filament bundle assembly#GO:0032231;regulation of organelle organization#GO:0033043;regulation of supramolecular fiber organization#GO:1902903;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;actin cytoskeleton organization#GO:0030036;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component biogenesis#GO:0044087;regulation of stress fiber assembly#GO:0051492;regulation of actin filament-based process#GO:0032970;cellular component organization or biogenesis#GO:0071840;positive regulation of actin filament bundle assembly#GO:0032233;actin filament organization#GO:0007015;organelle organization#GO:0006996;regulation of actin filament organization#GO:0110053;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of cellular component biogenesis#GO:0044089;regulation of actin cytoskeleton organization#GO:0032956;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=17023|UniProtKB=Q8WU17 Q8WU17 RNF139 PTHR22763:SF163 RING ZINC FINGER PROTEIN E3 UBIQUITIN-PROTEIN LIGASE RNF139 catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787 catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632 cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;membrane#GO:0016020;organelle membrane#GO:0031090;endoplasmic reticulum protein-containing complex#GO:0140534;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=17680|UniProtKB=Q9NYW8 Q9NYW8 RBAK PTHR23226:SF460 ZINC FINGER AND SCAN DOMAIN-CONTAINING RB-ASSOCIATED KRAB ZINC FINGER PROTEIN sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=8253|UniProtKB=O95918 O95918 OR2H2 PTHR26453:SF617 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2H2 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 detection of chemical stimulus#GO:0009593;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;response to stimulus#GO:0050896;response to chemical#GO:0042221;nervous system process#GO:0050877;sensory perception#GO:0007600;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;system process#GO:0003008 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=19041|UniProtKB=Q96D53 Q96D53 COQ8B PTHR43851:SF4 FAMILY NOT NAMED ATYPICAL KINASE COQ8B, MITOCHONDRIAL small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152;biosynthetic process#GO:0009058;small molecule metabolic process#GO:0044281;cellular process#GO:0009987;ketone biosynthetic process#GO:0042181;ubiquinone biosynthetic process#GO:0006744;ketone metabolic process#GO:0042180 HUMAN|HGNC=24520|UniProtKB=Q8NCA5 Q8NCA5 FAM98A PTHR31353:SF9 FAM98 PROTEIN FAM98A catalytic complex#GO:1902494;intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991 RNA processing factor#PC00147;RNA splicing factor#PC00148 HUMAN|HGNC=20707|UniProtKB=Q96PE5 Q96PE5 OPALIN PTHR21102:SF0 OPALIN OPALIN cell junction#GO:0030054;anchoring junction#GO:0070161;cell-cell contact zone#GO:0044291;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cell-cell junction#GO:0005911;membrane#GO:0016020;cell periphery#GO:0071944 HUMAN|HGNC=14488|UniProtKB=Q9BQ48 Q9BQ48 MRPL34 PTHR14503:SF4 MITOCHONDRIAL RIBOSOMAL PROTEIN 34 FAMILY MEMBER LARGE RIBOSOMAL SUBUNIT PROTEIN BL34M organelle lumen#GO:0043233;ribosome#GO:0005840;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;mitochondrial ribosome#GO:0005761;intracellular anatomical structure#GO:0005622;organellar ribosome#GO:0000313;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;mitochondrial large ribosomal subunit#GO:0005762;membraneless organelle#GO:0043228 ribosomal protein#PC00202 HUMAN|HGNC=8033|UniProtKB=Q16288 Q16288 NTRK3 PTHR24416:SF66 TYROSINE-PROTEIN KINASE RECEPTOR NT-3 GROWTH FACTOR RECEPTOR protein binding#GO:0005515;phosphotransferase activity, alcohol group as acceptor#GO:0016773;growth factor binding#GO:0019838;protein kinase activity#GO:0004672;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;transferase activity#GO:0016740;kinase activity#GO:0016301;transmembrane receptor protein tyrosine kinase activity#GO:0004714;molecular transducer activity#GO:0060089;catalytic activity, acting on a protein#GO:0140096;transmembrane receptor protein kinase activity#GO:0019199;protein tyrosine kinase activity#GO:0004713;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772 cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;signaling#GO:0023052;regulation of cellular process#GO:0050794;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;cell differentiation#GO:0030154;response to growth factor#GO:0070848;generation of neurons#GO:0048699;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;cellular response to growth factor stimulus#GO:0071363;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;cell communication#GO:0007154;cellular process#GO:0009987;signal transduction#GO:0007165;nervous system development#GO:0007399;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;cell surface receptor signaling pathway#GO:0007166;developmental process#GO:0032502;neuron differentiation#GO:0030182;neurogenesis#GO:0022008;cellular response to nerve growth factor stimulus#GO:1990090;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;axon#GO:0030424;signaling receptor complex#GO:0043235 transmembrane signal receptor#PC00197 HUMAN|HGNC=7843|UniProtKB=P28336 P28336 NMBR PTHR45695:SF8 LEUCOKININ RECEPTOR-RELATED NEUROMEDIN-B RECEPTOR G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888;neuropeptide receptor activity#GO:0008188;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;molecular transducer activity#GO:0060089 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=20488|UniProtKB=Q96EM0 Q96EM0 L3HYPDH PTHR33442:SF1 TRANS-3-HYDROXY-L-PROLINE DEHYDRATASE TRANS-3-HYDROXY-L-PROLINE DEHYDRATASE catalytic activity#GO:0003824;lyase activity#GO:0016829;carbon-oxygen lyase activity#GO:0016835;hydro-lyase activity#GO:0016836 dehydratase#PC00091;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=9963|UniProtKB=Q8NFH8 Q8NFH8 REPS2 PTHR11216:SF64 EH DOMAIN RALBP1-ASSOCIATED EPS DOMAIN-CONTAINING PROTEIN 2 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;import into cell#GO:0098657;endosomal transport#GO:0016197;intracellular transport#GO:0046907;transport#GO:0006810;endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 membrane traffic protein#PC00150 HUMAN|HGNC=11465|UniProtKB=Q9Y5B9 Q9Y5B9 SUPT16H PTHR13980:SF15 CDC68 RELATED FACT COMPLEX SUBUNIT SPT16 protein carrier activity#GO:0140597;protein-containing complex binding#GO:0044877;nucleosome binding#GO:0031491;binding#GO:0005488;molecular carrier activity#GO:0140104;chromatin binding#GO:0003682 biosynthetic process#GO:0009058;chromatin organization#GO:0006325;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;transcription elongation by RNA polymerase II#GO:0006368;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;DNA-templated transcription elongation#GO:0006354;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA biosynthetic process#GO:0032774;chromatin remodeling#GO:0006338;DNA-templated transcription#GO:0006351;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187 membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;membrane-enclosed lumen#GO:0031974;chromatin#GO:0000785;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;chromosome#GO:0005694;organelle lumen#GO:0043233;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;transcription elongation factor complex#GO:0008023 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=16512|UniProtKB=Q8WZ55 Q8WZ55 BSND PTHR28399:SF1 BARTTIN BARTTIN molecular function regulator activity#GO:0098772;channel regulator activity#GO:0016247;ion channel regulator activity#GO:0099106;transporter regulator activity#GO:0141108 chloride transport#GO:0006821;monoatomic anion transport#GO:0006820;transport#GO:0006810;establishment of localization#GO:0051234;localization#GO:0051179;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698 cell periphery#GO:0071944;basal plasma membrane#GO:0009925;membrane#GO:0016020;basolateral plasma membrane#GO:0016323;basal part of cell#GO:0045178;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590 HUMAN|HGNC=15566|UniProtKB=Q9H0C8 Q9H0C8 ILKAP PTHR13832:SF883 PROTEIN PHOSPHATASE 2C INTEGRIN-LINKED KINASE-ASSOCIATED SERINE_THREONINE PHOSPHATASE 2C hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721;protein serine/threonine phosphatase activity#GO:0004722;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell communication#GO:0007154 protein phosphatase#PC00195 HUMAN|HGNC=19061|UniProtKB=Q5NUL3 Q5NUL3 FFAR4 PTHR24241:SF67 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR FREE FATTY ACID RECEPTOR 4 molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 response to chemical#GO:0042221;biological regulation#GO:0065007;response to hormone#GO:0009725;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;cellular response to hormone stimulus#GO:0032870;regulation of cellular process#GO:0050794;signaling#GO:0023052;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=12435|UniProtKB=P10599 P10599 TXN PTHR10438:SF18 THIOREDOXIN THIOREDOXIN catalytic activity#GO:0003824;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491;protein-disulfide reductase activity#GO:0015035;disulfide oxidoreductase activity#GO:0015036 cell redox homeostasis#GO:0045454;homeostatic process#GO:0042592;cellular homeostasis#GO:0019725 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;cytosol#GO:0005829;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 Hypoxia response via HIF activation#P00030>Thioredoxin#P00825;Oxidative stress response#P00046>TRX#P01122 HUMAN|HGNC=29116|UniProtKB=O94876 O94876 TMCC1 PTHR17613:SF11 CEREBRAL PROTEIN-11-RELATED TRANSMEMBRANE AND COILED-COIL DOMAINS PROTEIN 1 cellular component organization#GO:0016043;membrane fission#GO:0090148;localization#GO:0051179;cellular localization#GO:0051641;organelle fission#GO:0048285;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle organization#GO:0006996;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;vesicle-mediated transport#GO:0016192;transport#GO:0006810;intracellular transport#GO:0046907;endosomal transport#GO:0016197;endosome organization#GO:0007032;vesicle organization#GO:0016050;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 HUMAN|HGNC=2597|UniProtKB=Q16678 Q16678 CYP1B1 PTHR24299:SF11 CYTOCHROME P450 FAMILY 1 CYTOCHROME P450 1B1 steroid hydroxylase activity#GO:0008395;catalytic activity#GO:0003824;monooxygenase activity#GO:0004497;oxidoreductase activity#GO:0016491 primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;regulation of hormone levels#GO:0010817;catabolic process#GO:0009056;response to stimulus#GO:0050896;xenobiotic metabolic process#GO:0006805;cellular response to chemical stimulus#GO:0070887;response to xenobiotic stimulus#GO:0009410;estrogen metabolic process#GO:0008210;regulation of biological quality#GO:0065008;steroid catabolic process#GO:0006706;cellular process#GO:0009987;lipid catabolic process#GO:0016042;hormone metabolic process#GO:0042445;response to chemical#GO:0042221;cellular response to xenobiotic stimulus#GO:0071466;steroid metabolic process#GO:0008202;biological regulation#GO:0065007;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;secondary metabolic process#GO:0019748 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739 oxidoreductase#PC00176;oxygenase#PC00177 HUMAN|HGNC=11478|UniProtKB=O75683 O75683 SURF6 PTHR14369:SF0 SURFEIT LOCUS PROTEIN 6 SURFEIT LOCUS PROTEIN 6 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;molecular condensate scaffold activity#GO:0140693 cellular component biogenesis#GO:0044085;ribosomal large subunit biogenesis#GO:0042273;ribosome biogenesis#GO:0042254;ribosomal small subunit biogenesis#GO:0042274;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;ribonucleoprotein complex biogenesis#GO:0022613 nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular organelle#GO:0043229;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 RNA metabolism protein#PC00031 HUMAN|HGNC=16951|UniProtKB=Q9Y6Y0 Q9Y6Y0 IVNS1ABP PTHR24412:SF396 KELCH PROTEIN INFLUENZA VIRUS NS1A-BINDING PROTEIN ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987 catalytic complex#GO:1902494;transferase complex#GO:1990234;ubiquitin ligase complex#GO:0000151;Cul3-RING ubiquitin ligase complex#GO:0031463;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;cullin-RING ubiquitin ligase complex#GO:0031461 scaffold/adaptor protein#PC00226 HUMAN|HGNC=14774|UniProtKB=Q8NHB8 Q8NHB8 OR5K2 PTHR26452:SF38 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5K2 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606;nervous system process#GO:0050877;sensory perception#GO:0007600 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=933|UniProtKB=P56817 P56817 BACE1 PTHR47965:SF69 ASPARTYL PROTEASE-RELATED BETA-SECRETASE 1 aspartic-type endopeptidase activity#GO:0004190;catalytic activity#GO:0003824;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 protein maturation#GO:0051604;gene expression#GO:0010467;membrane protein ectodomain proteolysis#GO:0006509;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059;membrane protein proteolysis#GO:0033619;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;proteolysis#GO:0006508 membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;Golgi apparatus#GO:0005794;endomembrane system#GO:0012505;plasma membrane#GO:0005886;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;cell periphery#GO:0071944 protease#PC00190 Alzheimer disease-amyloid secretase pathway#P00003>Pro-BACE-1#P00081;Alzheimer disease-presenilin pathway#P00004>Pro-BACE-1#P00162;Alzheimer disease-amyloid secretase pathway#P00003>BACE-1#P00101;Alzheimer disease-amyloid secretase pathway#P00003>BACE-1 pro-domain#P00094;Alzheimer disease-presenilin pathway#P00004>BACE-1#P00172;Alzheimer disease-presenilin pathway#P00004>BACE-1 pro-domain#P00178 HUMAN|HGNC=20312|UniProtKB=Q86VN1 Q86VN1 VPS36 PTHR13128:SF12 VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36 VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36 intracellular transport#GO:0046907;vacuolar transport#GO:0007034;transport#GO:0006810;establishment of protein localization to organelle#GO:0072594;macromolecule metabolic process#GO:0043170;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule localization#GO:0033036;late endosome to vacuole transport via multivesicular body sorting pathway#GO:0032511;multivesicular body sorting pathway#GO:0071985;endosome transport via multivesicular body sorting pathway#GO:0032509;ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043162;protein localization to vacuole#GO:0072665;localization#GO:0051179;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;protein localization to organelle#GO:0033365;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;intracellular protein transport#GO:0006886;endosomal transport#GO:0016197;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;cellular localization#GO:0051641;protein transport#GO:0015031;establishment of protein localization to vacuole#GO:0072666;late endosome to vacuole transport#GO:0045324;protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043328 vesicle membrane#GO:0012506;membrane#GO:0016020;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;late endosome#GO:0005770;late endosome membrane#GO:0031902;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;vesicle#GO:0031982;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endosome membrane#GO:0010008;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HUMAN|HGNC=15281|UniProtKB=Q8NGL3 Q8NGL3 OR5D14 PTHR48018:SF65 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5D14 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 nervous system process#GO:0050877;sensory perception#GO:0007600;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signaling#GO:0023052;sensory perception of smell#GO:0007608;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;cellular process#GO:0009987;signal transduction#GO:0007165;biological regulation#GO:0065007;multicellular organismal process#GO:0032501 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=15783|UniProtKB=Q6P4F7 Q6P4F7 ARHGAP11A PTHR15670:SF4 RHO GTPASE ACTIVATING PROTEIN 11A INACTIVE RHO GTPASE-ACTIVATING PROTEIN 11B-RELATED nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047 GTPase-activating protein#PC00257 HUMAN|HGNC=5823|UniProtKB=A0A0A0MRZ8 A0A0A0MRZ8 IGKV3D-11 PTHR23267:SF328 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN KAPPA VARIABLE 3-11-RELATED response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=3085|UniProtKB=P54792 P54792 DVL1P1 PTHR10878:SF5 SEGMENT POLARITY PROTEIN DISHEVELLED SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1-RELATED protein binding#GO:0005515;G protein-coupled receptor binding#GO:0001664;frizzled binding#GO:0005109;binding#GO:0005488;signaling receptor binding#GO:0005102 cell communication#GO:0007154;canonical Wnt signaling pathway#GO:0060070;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;Wnt signaling pathway#GO:0016055;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 Alzheimer disease-presenilin pathway#P00004>Dsh#P00132;Angiogenesis#P00005>Dsh#P00200;Wnt signaling pathway#P00057>Dishevelled#P01447 HUMAN|HGNC=29283|UniProtKB=Q9P266 Q9P266 JCAD PTHR34757:SF1 JUNCTIONAL PROTEIN ASSOCIATED WITH CORONARY ARTERY DISEASE JUNCTIONAL CADHERIN 5-ASSOCIATED PROTEIN regulation of cell population proliferation#GO:0042127;positive regulation of cell population proliferation#GO:0008284;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;positive regulation of epithelial cell proliferation#GO:0050679;biological regulation#GO:0065007 plasma membrane#GO:0005886;plasma membrane region#GO:0098590;cell periphery#GO:0071944;membrane#GO:0016020;cell-cell junction#GO:0005911;cell leading edge#GO:0031252;adherens junction#GO:0005912;ruffle#GO:0001726;cell junction#GO:0030054;ruffle membrane#GO:0032587;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;anchoring junction#GO:0070161;cell projection membrane#GO:0031253;leading edge membrane#GO:0031256 HUMAN|HGNC=16157|UniProtKB=Q96MP5 Q96MP5 ZSWIM3 PTHR31569:SF3 SWIM-TYPE DOMAIN-CONTAINING PROTEIN ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 3 HUMAN|HGNC=1372|UniProtKB=Q9ULX7 Q9ULX7 CA14 PTHR18952:SF84 CARBONIC ANHYDRASE CARBONIC ANHYDRASE 14 catalytic activity#GO:0003824;lyase activity#GO:0016829;carbon-oxygen lyase activity#GO:0016835;hydro-lyase activity#GO:0016836 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 dehydratase#PC00091;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=8653|UniProtKB=P05165 P05165 PCCA PTHR18866:SF130 CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE PROPIONYL-COA CARBOXYLASE ALPHA CHAIN, MITOCHONDRIAL catalytic activity#GO:0003824;ligase activity#GO:0016874 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 ligase#PC00142;metabolite interconversion enzyme#PC00262 Methylmalonyl pathway#P02755>Propionyl-CoA carboxylase#P03033 HUMAN|HGNC=9057|UniProtKB=Q96C90 Q96C90 PPP1R14B PTHR16188:SF5 PROTEIN PHOSPHATASE 1 INHIBITOR POTENTIATED BY PROTEIN KINASE C PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 14B protein phosphatase inhibitor activity#GO:0004864;enzyme inhibitor activity#GO:0004857;phosphatase regulator activity#GO:0019208;molecular function regulator activity#GO:0098772;phosphatase inhibitor activity#GO:0019212;protein serine/threonine phosphatase inhibitor activity#GO:0004865;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;protein phosphatase regulator activity#GO:0019888 innate immune response#GO:0045087;defense response#GO:0006952;response to external stimulus#GO:0009605;immune system process#GO:0002376;defense response to other organism#GO:0098542;response to stimulus#GO:0050896;response to other organism#GO:0051707;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;immune response#GO:0006955;defense response to symbiont#GO:0140546 phosphatase modulator#PC00184 HUMAN|Ensembl=ENSG00000262748.1|UniProtKB=A0A140TA62 A0A140TA62 LOC100653049 PTHR23239:SF165 INTERMEDIATE FILAMENT IF ROD DOMAIN-CONTAINING PROTEIN-RELATED structural molecule activity#GO:0005198 tissue morphogenesis#GO:0048729;anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;intermediate filament-based process#GO:0045103;animal gross anatomical part developmental process#GO:0160108;intermediate filament organization#GO:0045109;intermediate filament cytoskeleton organization#GO:0045104;cell differentiation#GO:0030154;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;morphogenesis of an epithelium#GO:0002009;developmental process#GO:0032502;epithelium development#GO:0060429;epithelial cell differentiation#GO:0030855;tissue development#GO:0009888;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular process#GO:0009987 intermediate filament#GO:0005882;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165 intermediate filament#PC00129 HUMAN|HGNC=1739|UniProtKB=O75419 O75419 CDC45 PTHR10507:SF0 CDC45-RELATED PROTEIN CELL DIVISION CONTROL PROTEIN 45 HOMOLOG double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;single-stranded DNA binding#GO:0003697;chromatin binding#GO:0003682;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA replication origin binding#GO:0003688;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 protein-DNA complex assembly#GO:0065004;cellular component assembly#GO:0022607;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;response to stress#GO:0006950;double-strand break repair#GO:0006302;protein-containing complex organization#GO:0043933;protein-DNA complex organization#GO:0071824;cellular component organization or biogenesis#GO:0071840;DNA recombination#GO:0006310;DNA replication initiation#GO:0006270;metabolic process#GO:0008152;nuclear DNA replication#GO:0033260;mitotic DNA replication#GO:1902969;DNA metabolic process#GO:0006259;response to stimulus#GO:0050896;protein-containing complex assembly#GO:0065003;cell cycle process#GO:0022402;double-strand break repair via homologous recombination#GO:0000724;cellular component organization#GO:0016043;DNA-templated DNA replication#GO:0006261;cellular response to stress#GO:0033554;nucleobase-containing compound metabolic process#GO:0006139;double-strand break repair via break-induced replication#GO:0000727;mitotic cell cycle process#GO:1903047;macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;DNA repair#GO:0006281;cell cycle DNA replication#GO:0044786;mitotic cell cycle#GO:0000278;cellular response to stimulus#GO:0051716;DNA replication#GO:0006260;cell cycle#GO:0007049;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;recombinational repair#GO:0000725 nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;protein-containing complex#GO:0032991;nuclear protein-containing complex#GO:0140513;DNA replication preinitiation complex#GO:0031261;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;protein-DNA complex#GO:0032993;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 replication origin binding protein#PC00199;DNA metabolism protein#PC00009 HUMAN|HGNC=27017|UniProtKB=Q3KRA6 Q3KRA6 C2orf76 PTHR18444:SF9 UPF0538 FAMILY MEMBER UPF0538 PROTEIN C2ORF76 HUMAN|HGNC=916|UniProtKB=Q9Y5Z6 Q9Y5Z6 B3GALT1 PTHR11214:SF20 BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE BETA-1,3-GALACTOSYLTRANSFERASE 1 galactosyltransferase activity#GO:0008378;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;catalytic activity#GO:0003824 biosynthetic process#GO:0009058;carbohydrate metabolic process#GO:0005975;carbohydrate biosynthetic process#GO:0016051;primary metabolic process#GO:0044238;cellular process#GO:0009987;oligosaccharide biosynthetic process#GO:0009312;oligosaccharide metabolic process#GO:0009311;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139 transferase#PC00220;glycosyltransferase#PC00111 HUMAN|HGNC=26901|UniProtKB=Q3ZCN5 Q3ZCN5 OTOGL PTHR11339:SF225 EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED OTOGELIN-LIKE PROTEIN extracellular matrix structural constituent#GO:0005201;structural molecule activity#GO:0005198 extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cellular anatomical structure#GO:0110165 extracellular matrix protein#PC00102 HUMAN|HGNC=30933|UniProtKB=Q9BXY8 Q9BXY8 BEX2 PTHR19430:SF2 PROTEIN BEX1-RELATED PROTEIN BEX2 protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488 cell communication#GO:0007154;regulation of apoptotic process#GO:0042981;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;regulation of programmed cell death#GO:0043067;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 HUMAN|HGNC=8971|UniProtKB=O00443 O00443 PIK3C2A PTHR10048:SF28 PHOSPHATIDYLINOSITOL KINASE PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT ALPHA phosphotransferase activity, alcohol group as acceptor#GO:0016773;lipid kinase activity#GO:0001727;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphatidylinositol kinase activity#GO:0052742;transferase activity#GO:0016740;catalytic activity#GO:0003824 intracellular signaling cassette#GO:0141124;biosynthetic process#GO:0009058;biological regulation#GO:0065007;lipid biosynthetic process#GO:0008610;cell migration#GO:0016477;glycerophospholipid metabolic process#GO:0006650;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;signal transduction#GO:0007165;phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0043491;organophosphate metabolic process#GO:0019637;lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474;metabolic process#GO:0008152;signaling#GO:0023052;phospholipid metabolic process#GO:0006644;cell motility#GO:0048870;regulation of cellular process#GO:0050794;phospholipid biosynthetic process#GO:0008654;glycerolipid metabolic process#GO:0046486;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;intracellular signal transduction#GO:0035556;organophosphate biosynthetic process#GO:0090407;cell communication#GO:0007154;phosphatidylinositol phosphate biosynthetic process#GO:0046854 cell periphery#GO:0071944;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 kinase#PC00137 FGF signaling pathway#P00021>PI3K#P00640;p53 pathway feedback loops 2#P04398>PI3K#P04661;Integrin signalling pathway#P00034>PI3K#P00936;Axon guidance mediated by netrin#P00009>PI3K#P00363;VEGF signaling pathway#P00056>PI3K#P01413;Angiogenesis#P00005>PI3K#P00236;p53 pathway#P00059>PI3K#P04609;Endothelin signaling pathway#P00019>PI3K#P00577;Hypoxia response via HIF activation#P00030>PI3K#P00823;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>PI3K#P00900;EGF receptor signaling pathway#P00018>PI3K#P00557 HUMAN|HGNC=1123|UniProtKB=Q13886 Q13886 KLF9 PTHR23235:SF132 KRUEPPEL-LIKE TRANSCRIPTION FACTOR KRUEPPEL-LIKE FACTOR 9 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=17890|UniProtKB=O60760 O60760 HPGDS PTHR11571:SF224 GLUTATHIONE S-TRANSFERASE HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE transferase activity#GO:0016740;catalytic activity#GO:0003824;glutathione transferase activity#GO:0004364;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765 cellular process#GO:0009987;metabolic process#GO:0008152;glutathione metabolic process#GO:0006749;modified amino acid metabolic process#GO:0006575;sulfur compound metabolic process#GO:0006790 transferase#PC00220 HUMAN|HGNC=23761|UniProtKB=Q9NVX7 Q9NVX7 KBTBD4 PTHR47195:SF1 KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 4 KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 4 HUMAN|HGNC=23531|UniProtKB=Q5VZY2 Q5VZY2 PLPP4 PTHR10165:SF90 LIPID PHOSPHATE PHOSPHATASE PHOSPHOLIPID PHOSPHATASE 4 catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787 metabolic process#GO:0008152;lipid metabolic process#GO:0006629;lipid modification#GO:0030258;dephosphorylation#GO:0016311;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;organophosphate metabolic process#GO:0019637;phosphate-containing compound metabolic process#GO:0006796;cellular process#GO:0009987;phospholipid dephosphorylation#GO:0046839;phospholipid metabolic process#GO:0006644 cellular anatomical structure#GO:0110165;membrane#GO:0016020 hydrolase#PC00121;phosphatase#PC00181 HUMAN|HGNC=21203|UniProtKB=Q8IV45 Q8IV45 UNC5CL PTHR12582:SF51 NETRIN RECEPTOR UNC5 UNC5C-LIKE PROTEIN transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 positive regulation of canonical NF-kappaB signal transduction#GO:0043123;positive regulation of MAPK cascade#GO:0043410;regulation of JNK cascade#GO:0046328;regulation of response to stimulus#GO:0048583;regulation of MAPK cascade#GO:0043408;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of canonical NF-kappaB signal transduction#GO:0043122;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of signaling#GO:0023056;positive regulation of JNK cascade#GO:0046330;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=18253|UniProtKB=Q9H300 Q9H300 PARL PTHR43731:SF14 RHOMBOID PROTEASE PRESENILIN-ASSOCIATED RHOMBOID-LIKE PROTEIN, MITOCHONDRIAL hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;serine-type peptidase activity#GO:0008236;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity#GO:0003824 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein processing#GO:0016485;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467;proteolysis#GO:0006508;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 intracellular organelle#GO:0043229;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 serine protease#PC00203 HUMAN|HGNC=21365|UniProtKB=Q9HD34 Q9HD34 LYRM4 PTHR13166:SF7 PROTEIN C6ORF149 LYR MOTIF-CONTAINING PROTEIN 4 iron-sulfur cluster assembly#GO:0016226;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;transferase complex#GO:1990234;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;sulfurtransferase complex#GO:1990228;cytoplasm#GO:0005737;cytosol#GO:0005829;mitochondrion#GO:0005739 HUMAN|HGNC=8336|UniProtKB=A0A2R8Y4L6 A0A2R8Y4L6 OR5D3 PTHR48018:SF170 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5D3 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 biological regulation#GO:0065007;multicellular organismal process#GO:0032501;cellular process#GO:0009987;signal transduction#GO:0007165;system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606;signaling#GO:0023052;sensory perception of smell#GO:0007608;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cell communication#GO:0007154;nervous system process#GO:0050877;sensory perception#GO:0007600;G protein-coupled receptor signaling pathway#GO:0007186 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=3754|UniProtKB=P21333 P21333 FLNA PTHR38537:SF5 JITTERBUG, ISOFORM N FILAMIN-A Integrin signalling pathway#P00034>Filamin#P00914;Nicotine pharmacodynamics pathway#P06587>FLNA#P06601;Dopamine receptor mediated signaling pathway#P05912>FLNA#P05959 HUMAN|HGNC=2261|UniProtKB=Q9Y6N1 Q9Y6N1 COX11 PTHR21320:SF8 CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11-RELATED CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11, MITOCHONDRIAL organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;organelle envelope#GO:0031967 chaperone#PC00072 HUMAN|HGNC=23697|UniProtKB=Q86UU1 Q86UU1 PHLDB1 PTHR12156:SF23 PLECKSTRIN HOMOLOGY-LIKE DOMAIN, FAMILY B, MEMBER 3 PLECKSTRIN HOMOLOGY-LIKE DOMAIN FAMILY B MEMBER 1 cellular process#GO:0009987;cellular component organization#GO:0016043;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;cell cortex#GO:0005938;basal part of cell#GO:0045178 HUMAN|HGNC=19980|UniProtKB=Q96EK6 Q96EK6 GNPNAT1 PTHR13355:SF11 GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE glucosamine 6-phosphate N-acetyltransferase activity#GO:0004343;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;catalytic activity#GO:0003824;transferase activity#GO:0016740 acetyltransferase#PC00038;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=2644|UniProtKB=P13584 P13584 CYP4B1 PTHR24291:SF149 CYTOCHROME P450 FAMILY 4 CYTOCHROME P450 4B1 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262;oxygenase#PC00177 HUMAN|HGNC=11939|UniProtKB=P41273 P41273 TNFSF9 PTHR15153:SF0 TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 9 TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 9 tumor necrosis factor receptor superfamily binding#GO:0032813;protein binding#GO:0005515;signaling receptor binding#GO:0005102;cytokine receptor binding#GO:0005126;binding#GO:0005488 regulation of lymphocyte activation#GO:0051249;positive regulation of T cell proliferation#GO:0042102;positive regulation of multicellular organismal process#GO:0051240;regulation of cell activation#GO:0050865;regulation of multicellular organismal development#GO:2000026;regulation of biological process#GO:0050789;positive regulation of cell population proliferation#GO:0008284;regulation of leukocyte activation#GO:0002694;positive regulation of mononuclear cell proliferation#GO:0032946;regulation of leukocyte proliferation#GO:0070663;positive regulation of leukocyte activation#GO:0002696;positive regulation of cell differentiation#GO:0045597;regulation of multicellular organismal process#GO:0051239;positive regulation of cell development#GO:0010720;regulation of T cell activation#GO:0050863;positive regulation of T cell activation#GO:0050870;positive regulation of biological process#GO:0048518;positive regulation of immune system process#GO:0002684;regulation of mononuclear cell proliferation#GO:0032944;positive regulation of cell-cell adhesion#GO:0022409;positive regulation of lymphocyte activation#GO:0051251;regulation of cell population proliferation#GO:0042127;regulation of hemopoiesis#GO:1903706;positive regulation of lymphocyte proliferation#GO:0050671;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;regulation of cell-cell adhesion#GO:0022407;regulation of immune system process#GO:0002682;regulation of T cell proliferation#GO:0042129;positive regulation of cell adhesion#GO:0045785;regulation of cell differentiation#GO:0045595;positive regulation of developmental process#GO:0051094;regulation of leukocyte cell-cell adhesion#GO:1903037;positive regulation of leukocyte proliferation#GO:0070665;positive regulation of cell activation#GO:0050867;positive regulation of leukocyte cell-cell adhesion#GO:1903039;biological regulation#GO:0065007;regulation of cell adhesion#GO:0030155;regulation of lymphocyte proliferation#GO:0050670;regulation of cell development#GO:0060284;positive regulation of cellular process#GO:0048522 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 intercellular signal molecule#PC00207 HUMAN|HGNC=9362|UniProtKB=P13727 P13727 PRG2 PTHR10068:SF16 BONE MARROW PROTEOGLYCAN BONE MARROW PROTEOGLYCAN extracellular matrix structural protein#PC00103 HUMAN|HGNC=15103|UniProtKB=Q8NGS7 Q8NGS7 OR13C8 PTHR26453:SF87 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 13C8 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 system process#GO:0003008;sensory perception#GO:0007600;nervous system process#GO:0050877;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;response to stimulus#GO:0050896;response to chemical#GO:0042221;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;detection of chemical stimulus#GO:0009593;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=14833|UniProtKB=Q8NH63 Q8NH63 OR51H1 PTHR26450:SF53 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 51H1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=32224|UniProtKB=Q0VD86 Q0VD86 INCA1 PTHR37341:SF1 PROTEIN INCA1 PROTEIN INCA1 enzyme inhibitor activity#GO:0004857;cyclin binding#GO:0030332;cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538;protein kinase regulator activity#GO:0019887;cyclin-dependent protein kinase regulator activity#GO:0019914;cyclin-dependent protein serine/threonine kinase inhibitor activity#GO:0004861;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;protein kinase inhibitor activity#GO:0004860;kinase inhibitor activity#GO:0019210;binding#GO:0005488;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;protein binding#GO:0005515 regulation of biological process#GO:0050789;negative regulation of cell population proliferation#GO:0008285;negative regulation of cellular process#GO:0048523;negative regulation of biological process#GO:0048519;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of cell population proliferation#GO:0042127 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=1173|UniProtKB=Q5H9R7 Q5H9R7 PPP6R3 PTHR12634:SF12 SIT4 YEAST -ASSOCIATING PROTEIN-RELATED SERINE_THREONINE-PROTEIN PHOSPHATASE 6 REGULATORY SUBUNIT 3 protein phosphatase regulator activity#GO:0019888;molecular function regulator activity#GO:0098772;phosphatase regulator activity#GO:0019208;enzyme regulator activity#GO:0030234 regulation of cell communication#GO:0010646;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;regulation of biological process#GO:0050789 nucleus#GO:0005634;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 phosphatase modulator#PC00184 HUMAN|HGNC=4390|UniProtKB=P50148 P50148 GNAQ PTHR10218:SF329 GTP-BINDING PROTEIN ALPHA SUBUNIT GUANINE NUCLEOTIDE-BINDING PROTEIN G(Q) SUBUNIT ALPHA GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity#GO:0016787;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817;molecular function regulator activity#GO:0098772;ribonucleoside triphosphate phosphatase activity#GO:0017111 cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;action potential#GO:0001508;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;phospholipase C-activating G protein-coupled receptor signaling pathway#GO:0007200;response to oxygen-containing compound#GO:1901700;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;regulation of biological quality#GO:0065008;response to nitrogen compound#GO:1901698;glutamate receptor signaling pathway#GO:0007215;cell communication#GO:0007154;cellular process#GO:0009987;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;G protein-coupled dopamine receptor signaling pathway#GO:0007212;biological regulation#GO:0065007;cellular response to nitrogen compound#GO:1901699;response to chemical#GO:0042221;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cell surface receptor signaling pathway#GO:0007166;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;regulation of membrane potential#GO:0042391 membrane#GO:0016020;cell periphery#GO:0071944;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cytoplasmic side of membrane#GO:0098562;extrinsic component of plasma membrane#GO:0019897;extrinsic component of membrane#GO:0019898;cytoplasmic side of plasma membrane#GO:0009898;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cellular anatomical structure#GO:0110165;extrinsic component of cytoplasmic side of plasma membrane#GO:0031234;catalytic complex#GO:1902494;side of membrane#GO:0098552;intracellular anatomical structure#GO:0005622 G-protein#PC00020;heterotrimeric G-protein#PC00117 Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>G-Protein#P01073;Cortocotropin releasing factor receptor signaling pathway#P04380>G-Protein#P04458;Histamine H1 receptor mediated signaling pathway#P04385>G-Protein#P04488;Oxytocin receptor mediated signaling pathway#P04391>G-Protein#P04534;Endothelin signaling pathway#P00019>Gq#P00586;Gonadotropin-releasing hormone receptor pathway#P06664>gnaq/11#P06841;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Galphaq#P00826;Thyrotropin-releasing hormone receptor signaling pathway#P04394>G-Protein#P04584;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Galphai/q#P00873;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Gqalpha#P00732;5HT2 type receptor mediated signaling pathway#P04374>G-protein#P04416;Wnt signaling pathway#P00057>Galpha#P01451;Angiotensin II-stimulated signaling through G proteins and beta-arrestin#P05911>Gqalpha#P05927;PI3 kinase pathway#P00048>Galpha#P01199;Metabotropic glutamate receptor group I pathway#P00041>G-Protein#P01057 HUMAN|HGNC=18120|UniProtKB=Q9NSA0 Q9NSA0 SLC22A11 PTHR24064:SF241 SOLUTE CARRIER FAMILY 22 MEMBER SOLUTE CARRIER FAMILY 22 MEMBER 11 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;transport#GO:0006810;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258 HUMAN|HGNC=37223|UniProtKB=P86478 P86478 PRR20E PTHR38819:SF1 PROLINE-RICH PROTEIN 20A-RELATED PROLINE-RICH PROTEIN 20A-RELATED HUMAN|HGNC=21714|UniProtKB=Q9P0W0 Q9P0W0 IFNK PTHR11691:SF6 TYPE I INTERFERON INTERFERON KAPPA binding#GO:0005488;signaling receptor binding#GO:0005102;cytokine receptor binding#GO:0005126;cytokine activity#GO:0005125;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;molecular function activator activity#GO:0140677;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772 response to external biotic stimulus#GO:0043207;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;leukocyte activation#GO:0045321;response to nitrogen compound#GO:1901698;cell communication#GO:0007154;cell activation#GO:0001775;cytokine-mediated signaling pathway#GO:0019221;biological regulation#GO:0065007;adaptive immune response#GO:0002250;response to other organism#GO:0051707;multicellular organismal process#GO:0032501;immune response#GO:0006955;response to external stimulus#GO:0009605;defense response#GO:0006952;innate immune response#GO:0045087;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;T cell activation#GO:0042110;cell activation involved in immune response#GO:0002263;response to peptide#GO:1901652;immune system process#GO:0002376;type I interferon-mediated signaling pathway#GO:0060337;B cell activation involved in immune response#GO:0002312;T cell activation involved in immune response#GO:0002286;response to chemical#GO:0042221;response to cytokine#GO:0034097;lymphocyte activation#GO:0046649;defense response to other organism#GO:0098542;lymphocyte activation involved in immune response#GO:0002285;defense response to symbiont#GO:0140546;signal transduction#GO:0007165;cellular process#GO:0009987;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;B cell activation#GO:0042113;cell surface receptor signaling pathway#GO:0007166;leukocyte activation involved in immune response#GO:0002366;immune effector process#GO:0002252;natural killer cell activation#GO:0030101;humoral immune response#GO:0006959 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 cytokine#PC00083;interferon superfamily#PC00127 HUMAN|HGNC=6486|UniProtKB=P07942 P07942 LAMB1 PTHR10574:SF233 NETRIN/LAMININ-RELATED LAMININ SUBUNIT BETA-1 cell adhesion molecule binding#GO:0050839;binding#GO:0005488;signaling receptor binding#GO:0005102;protein-containing complex binding#GO:0044877;integrin binding#GO:0005178;protein binding#GO:0005515 cell motility#GO:0048870;system development#GO:0048731;external encapsulating structure organization#GO:0045229;cell-substrate adhesion#GO:0031589;extracellular matrix organization#GO:0030198;anatomical structure development#GO:0048856;plasma membrane bounded cell projection organization#GO:0120036;cell migration#GO:0016477;tissue development#GO:0009888;extracellular matrix assembly#GO:0085029;multicellular organismal process#GO:0032501;axon guidance#GO:0007411;axon development#GO:0061564;neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;cell development#GO:0048468;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell morphogenesis#GO:0000902;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;neuron development#GO:0048666;axonogenesis#GO:0007409;cell adhesion#GO:0007155;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;extracellular structure organization#GO:0043062;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;cellular component assembly#GO:0022607;cellular process#GO:0009987;neuron projection development#GO:0031175;cellular component biogenesis#GO:0044085;cell projection morphogenesis#GO:0048858;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;substrate adhesion-dependent cell spreading#GO:0034446;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039 supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;basement membrane#GO:0005604;extracellular protein-containing complex#GO:0140392;extracellular region#GO:0005576 extracellular matrix protein#PC00102 Integrin signalling pathway#P00034>Laminin#P00947 HUMAN|HGNC=659|UniProtKB=P62330 P62330 ARF6 PTHR11711:SF480 ADP RIBOSYLATION FACTOR-RELATED ADP-RIBOSYLATION FACTOR 6 purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;nucleotide binding#GO:0000166;binding#GO:0005488;small molecule binding#GO:0036094;anion binding#GO:0043168;ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265;guanyl nucleotide binding#GO:0019001;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561 cellular localization#GO:0051641;localization#GO:0051179;protein transport#GO:0015031;regulation of biological process#GO:0050789;protein localization to organelle#GO:0033365;regulation of developmental process#GO:0050793;intracellular transport#GO:0046907;transport#GO:0006810;intracellular protein transport#GO:0006886;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;vesicle-mediated transport#GO:0016192;biological regulation#GO:0065007 endosome membrane#GO:0010008;endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endocytic vesicle#GO:0030139;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;recycling endosome#GO:0055037;ruffle#GO:0001726;recycling endosome membrane#GO:0055038;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane#GO:0016020;vesicle membrane#GO:0012506;cell leading edge#GO:0031252;cell periphery#GO:0071944;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;cytoplasm#GO:0005737;plasma membrane#GO:0005886 G-protein#PC00020 Huntington disease#P00029>ARF#P00786;Integrin signalling pathway#P00034>Arf6#P00919 HUMAN|HGNC=23758|UniProtKB=Q8IUS5 Q8IUS5 EPHX4 PTHR43329:SF2 EPOXIDE HYDROLASE EPOXIDE HYDROLASE 4 catalytic activity#GO:0003824;hydrolase activity#GO:0016787;ether hydrolase activity#GO:0016803 metabolic process#GO:0008152;primary metabolic process#GO:0044238;lipid metabolic process#GO:0006629;cellular process#GO:0009987 hydrolase#PC00121 HUMAN|HGNC=2480|UniProtKB=O60676 O60676 CST8 PTHR47010:SF1 CYSTATIN-8-RELATED CYSTATIN-8 extracellular region#GO:0005576;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cell surface#GO:0009986;cellular anatomical structure#GO:0110165 HUMAN|HGNC=4715|UniProtKB=Q02539 Q02539 H1-1 PTHR11467:SF176 HISTONE H1 HISTONE H1.1 nucleosome binding#GO:0031491;double-stranded DNA binding#GO:0003690;protein-containing complex binding#GO:0044877;DNA binding#GO:0003677;chromatin binding#GO:0003682;nucleic acid binding#GO:0003676;binding#GO:0005488;chromatin DNA binding#GO:0031490 regulation of DNA recombination#GO:0000018;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;chromosome condensation#GO:0030261;regulation of biological process#GO:0050789;regulation of DNA metabolic process#GO:0051052;negative regulation of biological process#GO:0048519;negative regulation of DNA recombination#GO:0045910;cellular component organization#GO:0016043;negative regulation of metabolic process#GO:0009892;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of cellular process#GO:0048523;chromosome organization#GO:0051276;cellular component organization or biogenesis#GO:0071840;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;organelle organization#GO:0006996;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;negative regulation of DNA metabolic process#GO:0051053;regulation of nucleobase-containing compound metabolic process#GO:0019219 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=3076|UniProtKB=Q99956 Q99956 DUSP9 PTHR10159:SF388 DUAL SPECIFICITY PROTEIN PHOSPHATASE DUAL SPECIFICITY PROTEIN PHOSPHATASE 9 protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721;protein tyrosine phosphatase activity#GO:0004725;hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;protein tyrosine/serine/threonine phosphatase activity#GO:0008138;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578 regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;negative regulation of cell communication#GO:0010648;cell communication#GO:0007154;negative regulation of intracellular signal transduction#GO:1902532;regulation of biological process#GO:0050789;negative regulation of MAPK cascade#GO:0043409;cellular response to stimulus#GO:0051716;negative regulation of biological process#GO:0048519;signaling#GO:0023052;regulation of cell communication#GO:0010646;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of MAPK cascade#GO:0043408;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of signal transduction#GO:0009968;regulation of ERK1 and ERK2 cascade#GO:0070372;negative regulation of ERK1 and ERK2 cascade#GO:0070373;negative regulation of response to stimulus#GO:0048585 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protein phosphatase#PC00195 Oxidative stress response#P00046>MKP5#P01131 HUMAN|HGNC=10479|UniProtKB=P48443 P48443 RXRG PTHR24083:SF100 NUCLEAR HORMONE RECEPTOR RETINOIC ACID RECEPTOR RXR-GAMMA sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulator activity#GO:0140110;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;molecular transducer activity#GO:0060089;DNA binding#GO:0003677;nuclear receptor activity#GO:0004879;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 response to hormone#GO:0009725;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;response to chemical#GO:0042221;positive regulation of macromolecule metabolic process#GO:0010604;nervous system development#GO:0007399;positive regulation of transcription by RNA polymerase II#GO:0045944;multicellular organism development#GO:0007275;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;cellular response to hormone stimulus#GO:0032870;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;signaling#GO:0023052;animal gross anatomical part developmental process#GO:0160108;cellular response to chemical stimulus#GO:0070887;hormone-mediated signaling pathway#GO:0009755;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of DNA-templated transcription#GO:0045893;multicellular organismal process#GO:0032501;nuclear receptor-mediated signaling pathway#GO:0141193;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;intracellular receptor signaling pathway#GO:0030522;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;cell communication#GO:0007154;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;intracellular signal transduction#GO:0035556;system development#GO:0048731 transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575 C4 zinc finger nuclear receptor#PC00169;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=25541|UniProtKB=P57088 P57088 TMEM33 PTHR12703:SF4 TRANSMEMBRANE PROTEIN 33 TRANSMEMBRANE PROTEIN 33 endoplasmic reticulum membrane organization#GO:0090158;nucleus organization#GO:0006997;cellular component organization or biogenesis#GO:0071840;nuclear envelope organization#GO:0006998;cellular component organization#GO:0016043;organelle organization#GO:0006996;nuclear membrane organization#GO:0071763;cellular process#GO:0009987;endoplasmic reticulum organization#GO:0007029;endoplasmic reticulum tubular network organization#GO:0071786;membrane organization#GO:0061024;endomembrane system organization#GO:0010256 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;nucleus#GO:0005634;organelle envelope#GO:0031967 HUMAN|HGNC=10601|UniProtKB=P51172 P51172 SCNN1D PTHR11690:SF132 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED EPITHELIAL SODIUM CHANNEL SUBUNIT DELTA sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836 sodium ion transmembrane transport#GO:0035725;sodium ion transport#GO:0006814;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;establishment of localization#GO:0051234 cell periphery#GO:0071944;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane#GO:0005886;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cation channel complex#GO:0034703;sodium channel complex#GO:0034706;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495 ion channel#PC00133;transporter#PC00227 HUMAN|HGNC=1613|UniProtKB=O14618 O14618 CCS PTHR10003:SF86 SUPEROXIDE DISMUTASE CU-ZN -RELATED COPPER CHAPERONE FOR SUPEROXIDE DISMUTASE oxidoreductase activity#GO:0016491;antioxidant activity#GO:0016209;catalytic activity#GO:0003824;copper ion binding#GO:0005507;metal ion binding#GO:0046872;cation binding#GO:0043169;ion binding#GO:0043167;molecular carrier activity#GO:0140104;small molecule binding#GO:0036094;binding#GO:0005488;transition metal ion binding#GO:0046914 cellular detoxification#GO:1990748;response to oxygen-containing compound#GO:1901700;cellular response to stress#GO:0033554;cellular response to chemical stimulus#GO:0070887;response to toxic substance#GO:0009636;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;response to reactive oxygen species#GO:0000302;superoxide metabolic process#GO:0006801;cellular response to chemical stress#GO:0062197;response to oxidative stress#GO:0006979;reactive oxygen species metabolic process#GO:0072593;metabolic process#GO:0008152;cellular response to toxic substance#GO:0097237;detoxification#GO:0098754;cellular response to oxidative stress#GO:0034599;response to chemical#GO:0042221;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;cellular oxidant detoxification#GO:0098869;response to stress#GO:0006950 oxidoreductase#PC00176 HUMAN|HGNC=24247|UniProtKB=Q8IVS8 Q8IVS8 GLYCTK PTHR12227:SF0 GLYCERATE KINASE GLYCERATE KINASE phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 carbohydrate kinase#PC00065 HUMAN|HGNC=118|UniProtKB=Q99798 Q99798 ACO2 PTHR43160:SF3 ACONITATE HYDRATASE B ACONITATE HYDRATASE, MITOCHONDRIAL catalytic activity#GO:0003824;small molecule binding#GO:0036094;binding#GO:0005488;hydro-lyase activity#GO:0016836;iron-sulfur cluster binding#GO:0051536;lyase activity#GO:0016829;carbon-oxygen lyase activity#GO:0016835 tricarboxylic acid cycle#GO:0006099;primary metabolic process#GO:0044238;cellular process#GO:0009987;energy derivation by oxidation of organic compounds#GO:0015980;cellular respiration#GO:0045333;aerobic respiration#GO:0009060;metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cytosol#GO:0005829;mitochondrion#GO:0005739 lyase#PC00144;hydratase#PC00120 TCA cycle#P00051>Aconitase#P01268 HUMAN|HGNC=24990|UniProtKB=Q9Y2R0 Q9Y2R0 COA3 PTHR15642:SF3 CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3, MITOCHONDRIAL CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3 HOMOLOG, MITOCHONDRIAL mitochondrial respiratory chain complex IV assembly#GO:0033617;cytochrome complex assembly#GO:0017004;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;respiratory chain complex IV assembly#GO:0008535;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;cellular component assembly#GO:0022607;mitochondrial respiratory chain complex assembly#GO:0033108;mitochondrion organization#GO:0007005 membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020 chaperone#PC00072 HUMAN|HGNC=14180|UniProtKB=Q13087 Q13087 PDIA2 PTHR18929:SF93 PROTEIN DISULFIDE ISOMERASE PROTEIN DISULFIDE-ISOMERASE A2 catalytic activity#GO:0003824;protein disulfide isomerase activity#GO:0003756;intramolecular oxidoreductase activity#GO:0016860;catalytic activity, acting on a protein#GO:0140096;isomerase activity#GO:0016853 primary metabolic process#GO:0044238;response to stress#GO:0006950;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;protein folding#GO:0006457;metabolic process#GO:0008152;response to endoplasmic reticulum stress#GO:0034976;cellular response to stress#GO:0033554;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 chaperone#PC00072 HUMAN|HGNC=24739|UniProtKB=Q17RQ9 Q17RQ9 NKPD1 PTHR22674:SF4 NTPASE, KAP FAMILY P-LOOP DOMAIN-CONTAINING 1 NTPASE KAP FAMILY P-LOOP DOMAIN-CONTAINING PROTEIN 1 HUMAN|HGNC=27407|UniProtKB=Q147U7 Q147U7 SMCO1 PTHR35979:SF1 SINGLE-PASS MEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1 SINGLE-PASS MEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1 HUMAN|HGNC=15715|UniProtKB=Q66K74 Q66K74 MAP1S PTHR13843:SF11 MICROTUBULE-ASSOCIATED PROTEIN MICROTUBULE-ASSOCIATED PROTEIN 1S protein binding#GO:0005515;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;binding#GO:0005488;microtubule binding#GO:0008017 neuron development#GO:0048666;axonogenesis#GO:0007409;dendrite development#GO:0016358;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;cell morphogenesis#GO:0000902;regulation of cellular component organization#GO:0051128;cell differentiation#GO:0030154;cell projection organization#GO:0030030;regulation of organelle organization#GO:0033043;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;microtubule-based process#GO:0007017;cell projection morphogenesis#GO:0048858;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;regulation of microtubule cytoskeleton organization#GO:0070507;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;cytoskeleton organization#GO:0007010;cellular process#GO:0009987;regulation of protein-containing complex disassembly#GO:0043244;neuron projection development#GO:0031175;organelle organization#GO:0006996;system development#GO:0048731;anatomical structure development#GO:0048856;microtubule cytoskeleton organization#GO:0000226;regulation of microtubule-based process#GO:0032886;regulation of cellular process#GO:0050794;regulation of cytoskeleton organization#GO:0051493;regulation of supramolecular fiber organization#GO:1902903;regulation of protein depolymerization#GO:1901879;neurogenesis#GO:0022008;regulation of microtubule polymerization or depolymerization#GO:0031110;cellular developmental process#GO:0048869;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;axon development#GO:0061564 cell projection#GO:0042995;neuronal cell body#GO:0043025;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell body#GO:0044297;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;intracellular organelle#GO:0043229;dendritic tree#GO:0097447;dendrite#GO:0030425;somatodendritic compartment#GO:0036477;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;microtubule associated complex#GO:0005875;neuron projection#GO:0043005;microtubule cytoskeleton#GO:0015630;cytosol#GO:0005829;cell junction#GO:0030054;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cytoskeleton#GO:0005856 non-motor microtubule binding protein#PC00166;cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=26818|UniProtKB=Q68D10 Q68D10 SPTY2D1 PTHR22691:SF8 YEAST SPT2-RELATED PROTEIN SPT2 HOMOLOG nucleic acid binding#GO:0003676;binding#GO:0005488;histone binding#GO:0042393;protein binding#GO:0005515;DNA binding#GO:0003677 nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;protein-containing complex assembly#GO:0065003;DNA-templated transcription#GO:0006351;chromatin remodeling#GO:0006338;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;transcription by RNA polymerase I#GO:0006360;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;cellular component assembly#GO:0022607;protein-DNA complex assembly#GO:0065004;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;chromatin organization#GO:0006325;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;nucleosome organization#GO:0034728;cellular component organization or biogenesis#GO:0071840;protein-DNA complex organization#GO:0071824;macromolecule metabolic process#GO:0043170;protein-containing complex organization#GO:0043933 nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=27652|UniProtKB=Q8WVH0 Q8WVH0 CPLX3 PTHR16705:SF5 COMPLEXIN COMPLEXIN-3 SNARE binding#GO:0000149;binding#GO:0005488;protein binding#GO:0005515 regulation of organelle organization#GO:0033043;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;regulation of cellular component organization#GO:0051128;signaling#GO:0023052;export from cell#GO:0140352;regulation of signaling#GO:0023051;cellular localization#GO:0051641;secretion by cell#GO:0032940;synaptic signaling#GO:0099536;cellular process#GO:0009987;synaptic vesicle exocytosis#GO:0016079;establishment of localization in cell#GO:0051649;regulation of trans-synaptic signaling#GO:0099177;vesicle-mediated transport#GO:0016192;neurotransmitter transport#GO:0006836;regulated exocytosis#GO:0045055;vesicle-mediated transport in synapse#GO:0099003;regulation of transport#GO:0051049;regulation of localization#GO:0032879;exocytosis#GO:0006887;chemical synaptic transmission#GO:0007268;signal release from synapse#GO:0099643;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;regulation of cell communication#GO:0010646;modulation of chemical synaptic transmission#GO:0050804;trans-synaptic signaling#GO:0099537;signal release#GO:0023061;secretion#GO:0046903;localization#GO:0051179;cell communication#GO:0007154;neurotransmitter secretion#GO:0007269;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;synaptic vesicle cycle#GO:0099504;transport#GO:0006810;establishment of localization#GO:0051234 protein-containing complex#GO:0032991;cytoplasm#GO:0005737;membrane#GO:0016020;neuron projection#GO:0043005;presynapse#GO:0098793;cell junction#GO:0030054;axon terminus#GO:0043679;cellular anatomical structure#GO:0110165;SNARE complex#GO:0031201;synapse#GO:0045202;neuron projection terminus#GO:0044306;cell projection#GO:0042995;terminal bouton#GO:0043195;plasma membrane bounded cell projection#GO:0120025;distal axon#GO:0150034;membrane protein complex#GO:0098796;intracellular anatomical structure#GO:0005622;axon#GO:0030424 HUMAN|HGNC=6865|UniProtKB=Q8IVH8 Q8IVH8 MAP4K3 PTHR48012:SF17 STERILE20-LIKE KINASE, ISOFORM B-RELATED MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 3 protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740 signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Gonadotropin-releasing hormone receptor pathway#P06664>MAP4Ks#P06861;Apoptosis signaling pathway#P00006>GCKR#P00311 HUMAN|HGNC=6601|UniProtKB=P49917 P49917 LIG4 PTHR45997:SF4 DNA LIGASE 4 DNA LIGASE 4 nucleotide binding#GO:0000166;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;DNA binding#GO:0003677;ion binding#GO:0043167;nucleic acid binding#GO:0003676;anion binding#GO:0043168;small molecule binding#GO:0036094;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;catalytic activity, acting on DNA#GO:0140097;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;ligase activity#GO:0016874;ribonucleotide binding#GO:0032553;nucleoside phosphate binding#GO:1901265;ATP binding#GO:0005524;binding#GO:0005488 somatic diversification of immune receptors#GO:0002200;cellular response to stimulus#GO:0051716;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;system development#GO:0048731;anatomical structure development#GO:0048856;macromolecule biosynthetic process#GO:0009059;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;somatic cell DNA recombination#GO:0016444;multicellular organismal process#GO:0032501;DNA damage response#GO:0006974;developmental process#GO:0032502;DNA repair#GO:0006281;macromolecule metabolic process#GO:0043170;double-strand break repair via nonhomologous end joining#GO:0006303;V(D)J recombination#GO:0033151;response to stimulus#GO:0050896;production of molecular mediator of immune response#GO:0002440;cellular response to stress#GO:0033554;somatic diversification of immune receptors via germline recombination within a single locus#GO:0002562;immune system process#GO:0002376;animal gross anatomical part developmental process#GO:0160108;immune system development#GO:0002520;cellular process#GO:0009987;somatic recombination of immunoglobulin gene segments#GO:0016447;response to stress#GO:0006950;nucleotide-excision repair#GO:0006289;gene expression#GO:0010467;DNA recombination#GO:0006310;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;double-strand break repair#GO:0006302;multicellular organism development#GO:0007275 nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nonhomologous end joining complex#GO:0070419;nucleus#GO:0005634;DNA repair complex#GO:1990391 DNA metabolism protein#PC00009 HUMAN|HGNC=4164|UniProtKB=P01350 P01350 GAST PTHR19309:SF0 GASTRIN GASTRIN receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;hormone activity#GO:0005179 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 peptide hormone#PC00179;intercellular signal molecule#PC00207 CCKR signaling map#P06959>G34-Gly#P07036;CCKR signaling map#P06959>G34#P07190;CCKR signaling map#P06959>Beta-arrestin-1/2#P07187;CCKR signaling map#P06959>G17 - Gly#P07236;CCKR signaling map#P06959>G17#P07215 HUMAN|HGNC=18116|UniProtKB=Q07666 Q07666 KHDRBS1 PTHR11208:SF30 RNA-BINDING PROTEIN RELATED KH DOMAIN-CONTAINING, RNA-BINDING, SIGNAL TRANSDUCTION-ASSOCIATED PROTEIN 1 RNA binding#GO:0003723;single-stranded RNA binding#GO:0003727;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488;poly(A) binding#GO:0008143 regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of biological process#GO:0050789;regulation of alternative mRNA splicing, via spliceosome#GO:0000381;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of mRNA processing#GO:0050684;biological regulation#GO:0065007;regulation of RNA splicing#GO:0043484;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biosynthetic process#GO:0009889;regulation of mRNA metabolic process#GO:1903311;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 RNA processing factor#PC00147;RNA splicing factor#PC00148 HUMAN|HGNC=14169|UniProtKB=Q6P587 Q6P587 FAHD1 PTHR11820:SF106 ACYLPYRUVASE OXALOACETATE TAUTOMERASE FAHD1, MITOCHONDRIAL catalytic activity#GO:0003824;hydrolase activity#GO:0016787 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 hydrolase#PC00121;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=6260|UniProtKB=Q9UNX9 Q9UNX9 KCNJ14 PTHR11767:SF40 INWARD RECTIFIER POTASSIUM CHANNEL ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 14 monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;potassium channel activity#GO:0005267;ligand-gated monoatomic ion channel activity#GO:0015276;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244 import across plasma membrane#GO:0098739;metal ion transport#GO:0030001;inorganic ion import across plasma membrane#GO:0099587;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;potassium ion transport#GO:0006813;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987;potassium ion import across plasma membrane#GO:1990573;import into cell#GO:0098657;establishment of localization#GO:0051234;inorganic cation import across plasma membrane#GO:0098659;transport#GO:0006810 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 ion channel#PC00133 HUMAN|HGNC=3438|UniProtKB=Q03468 Q03468 ERCC6 PTHR45629:SF15 SNF2/RAD54 FAMILY MEMBER DNA EXCISION REPAIR PROTEIN ERCC-6 ATP-dependent activity#GO:0140657;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;catalytic activity, acting on DNA#GO:0140097;ATP-dependent activity, acting on DNA#GO:0008094 DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139;nucleotide-excision repair#GO:0006289 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 damaged DNA-binding protein#PC00086 HUMAN|HGNC=29642|UniProtKB=A6NFN9 A6NFN9 ANKUB1 PTHR46885:SF1 PROTEIN ANKUB1 PROTEIN ANKUB1 HUMAN|HGNC=2419|UniProtKB=Q08257 Q08257 CRYZ PTHR44154:SF1 QUINONE OXIDOREDUCTASE ZETA-CRYSTALLIN binding#GO:0005488;nucleoside phosphate binding#GO:1901265;mRNA binding#GO:0003729;oxidoreductase activity, acting on NAD(P)H#GO:0016651;purine nucleotide binding#GO:0017076;mRNA 3'-UTR binding#GO:0003730;heterocyclic compound binding#GO:1901363;nucleic acid binding#GO:0003676;small molecule binding#GO:0036094;anion binding#GO:0043168;ion binding#GO:0043167;RNA binding#GO:0003723;catalytic activity#GO:0003824;oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor#GO:0016655;nucleotide binding#GO:0000166;oxidoreductase activity#GO:0016491 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 Huntington disease#P00029>PIG3#G01535 HUMAN|HGNC=7885|UniProtKB=P48745 P48745 CCN3 PTHR11348:SF8 CONNECTIVE TISSUE GROWTH FACTOR-RELATED CCN FAMILY MEMBER 3 integrin binding#GO:0005178;carbohydrate derivative binding#GO:0097367;heparin binding#GO:0008201;cell adhesion molecule binding#GO:0050839;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;glycosaminoglycan binding#GO:0005539;binding#GO:0005488;signaling receptor binding#GO:0005102 animal gross anatomical part developmental process#GO:0160108;cell adhesion#GO:0007155;anatomical structure development#GO:0048856;cell communication#GO:0007154;skeletal system development#GO:0001501;cartilage development#GO:0051216;system development#GO:0048731;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cell differentiation#GO:0030154;regulation of developmental process#GO:0050793;signaling#GO:0023052;positive regulation of cell differentiation#GO:0045597;regulation of cell differentiation#GO:0045595;developmental process#GO:0032502;positive regulation of developmental process#GO:0051094;animal organ development#GO:0048513;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;connective tissue development#GO:0061448;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;tissue development#GO:0009888;multicellular organismal process#GO:0032501;chondrocyte differentiation#GO:0002062;biological regulation#GO:0065007 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 growth factor#PC00112;intercellular signal molecule#PC00207 HUMAN|HGNC=29935|UniProtKB=Q9BXB7 Q9BXB7 SPATA16 PTHR47228:SF1 SPERMATOGENESIS-ASSOCIATED PROTEIN 16 SPERMATOGENESIS-ASSOCIATED PROTEIN 16 multicellular organismal reproductive process#GO:0048609;developmental process#GO:0032502;spermatogenesis#GO:0007283;sexual reproduction#GO:0019953;gamete generation#GO:0007276;male gamete generation#GO:0048232;reproductive process#GO:0022414;developmental process involved in reproduction#GO:0003006 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 HUMAN|HGNC=54201|UniProtKB=A0A1W2PRP0 A0A1W2PRP0 FOXL3 PTHR11829:SF211 FORKHEAD BOX PROTEIN FORKHEAD BOX PROTEIN L3 DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA metabolic process#GO:0051252;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=28211|UniProtKB=Q96I45 Q96I45 TMEM141 PTHR47229:SF1 TRANSMEMBRANE PROTEIN 141 TRANSMEMBRANE PROTEIN 141 HUMAN|HGNC=34436|UniProtKB=Q6ZST4 Q6ZST4 LCNL1 PTHR11430:SF77 LIPOCALIN LIPOCALIN-LIKE 1 PROTEIN transfer/carrier protein#PC00219 HUMAN|HGNC=24891|UniProtKB=Q5TAQ9 Q5TAQ9 DCAF8 PTHR15574:SF57 WD REPEAT DOMAIN-CONTAINING FAMILY DDB1- AND CUL4-ASSOCIATED FACTOR 8 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;cullin-RING ubiquitin ligase complex#GO:0031461;Cul4-RING E3 ubiquitin ligase complex#GO:0080008;transferase complex#GO:1990234;catalytic complex#GO:1902494;ubiquitin ligase complex#GO:0000151;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=14645|UniProtKB=Q9H8X2 Q9H8X2 IPPK PTHR14456:SF2 INOSITOL POLYPHOSPHATE KINASE 1 INOSITOL-PENTAKISPHOSPHATE 2-KINASE phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 small molecule metabolic process#GO:0044281;biosynthetic process#GO:0009058;phosphorus metabolic process#GO:0006793;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;alcohol biosynthetic process#GO:0046165;organophosphate biosynthetic process#GO:0090407;alcohol metabolic process#GO:0006066;metabolic process#GO:0008152;small molecule biosynthetic process#GO:0044283 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 kinase#PC00137 HUMAN|HGNC=4871|UniProtKB=Q9BVR0 Q9BVR0 HERC2P3 PTHR24202:SF4 E3 UBIQUITIN-PROTEIN LIGASE MIB2 E3 UBIQUITIN-PROTEIN LIGASE MIB2-RELATED acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;protein modification process#GO:0036211;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=9640|UniProtKB=Q6Y1H2 Q6Y1H2 HACD2 PTHR11035:SF17 VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE 2 catalytic activity#GO:0003824;hydro-lyase activity#GO:0016836;carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829 oxoacid metabolic process#GO:0043436;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid biosynthetic process#GO:0046394;small molecule metabolic process#GO:0044281;very long-chain fatty acid metabolic process#GO:0000038;fatty acid metabolic process#GO:0006631;sphingolipid biosynthetic process#GO:0030148;metabolic process#GO:0008152;sphingolipid metabolic process#GO:0006665;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;monocarboxylic acid biosynthetic process#GO:0072330;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058;fatty acid biosynthetic process#GO:0006633 organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020 dehydratase#PC00091 HUMAN|HGNC=11877|UniProtKB=P57727 P57727 TMPRSS3 PTHR24253:SF86 TRANSMEMBRANE PROTEASE SERINE TRANSMEMBRANE PROTEASE SERINE 3 serine-type peptidase activity#GO:0008236;catalytic activity#GO:0003824;serine hydrolase activity#GO:0017171;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096 metabolic process#GO:0008152;system process#GO:0003008;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;protein processing#GO:0016485;cellular process#GO:0009987;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604;multicellular organismal process#GO:0032501;nervous system process#GO:0050877;sensory perception of mechanical stimulus#GO:0050954;sensory perception#GO:0007600;proteolysis#GO:0006508;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;sensory perception of sound#GO:0007605 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 protease#PC00190;serine protease#PC00203;protein modifying enzyme#PC00260 HUMAN|HGNC=4669|UniProtKB=O00178 O00178 GTPBP1 PTHR43721:SF9 ELONGATION FACTOR TU-RELATED GTP-BINDING PROTEIN 1 translation elongation factor activity#GO:0003746;translation factor activity#GO:0180051 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;translation#GO:0006412;metabolic process#GO:0008152;translational elongation#GO:0006414;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 translation elongation factor#PC00222 HUMAN|HGNC=37165|UniProtKB=P0CJ75 P0CJ75 MTRNR2L8 PTHR33895:SF15 HUMANIN-LIKE 4 HUMANIN-LIKE 8 molecular function inhibitor activity#GO:0140678;molecular function regulator activity#GO:0098772;signaling receptor inhibitor activity#GO:0030547;signaling receptor regulator activity#GO:0030545 negative regulation of cellular process#GO:0048523;regulation of apoptotic process#GO:0042981;regulation of cellular process#GO:0050794;negative regulation of apoptotic process#GO:0043066;biological regulation#GO:0065007;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;negative regulation of programmed cell death#GO:0043069;regulation of biological process#GO:0050789 HUMAN|HGNC=7641|UniProtKB=P54920 P54920 NAPA PTHR13768:SF23 SOLUBLE NSF ATTACHMENT PROTEIN SNAP ALPHA-SOLUBLE NSF ATTACHMENT PROTEIN protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 cellular localization#GO:0051641;cellular component disassembly#GO:0022411;protein transport#GO:0015031;cellular component organization#GO:0016043;regulation of protein-containing complex assembly#GO:0043254;regulation of biological process#GO:0050789;regulation of cellular component organization#GO:0051128;regulation of cellular component biogenesis#GO:0044087;signaling#GO:0023052;intracellular protein transport#GO:0006886;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;synaptic signaling#GO:0099536;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;synaptic transmission, glutamatergic#GO:0035249;trans-synaptic signaling#GO:0099537;localization#GO:0051179;cell communication#GO:0007154;chemical synaptic transmission#GO:0007268;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;protein-containing complex disassembly#GO:0032984;intracellular transport#GO:0046907;transport#GO:0006810;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;cell-cell signaling#GO:0007267;biological regulation#GO:0065007 cell junction#GO:0030054;axon terminus#GO:0043679;membrane#GO:0016020;presynapse#GO:0098793;neuron projection#GO:0043005;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;axon#GO:0030424;intracellular anatomical structure#GO:0005622;membrane protein complex#GO:0098796;cellular anatomical structure#GO:0110165;synapse#GO:0045202;SNARE complex#GO:0031201;terminal bouton#GO:0043195;plasma membrane bounded cell projection#GO:0120025;distal axon#GO:0150034;neuron projection terminus#GO:0044306;cell projection#GO:0042995 membrane traffic protein#PC00150 HUMAN|HGNC=28203|UniProtKB=Q9BR77 Q9BR77 CCDC77 PTHR22091:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 77 COILED-COIL DOMAIN-CONTAINING PROTEIN 77 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;centrosome#GO:0005813;microtubule organizing center#GO:0005815;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=5393|UniProtKB=Q5VY09 Q5VY09 IER5 PTHR15895:SF12 IMMEDIATE EARLY RESPONSE GENE IMMEDIATE EARLY RESPONSE GENE 5 PROTEIN HUMAN|HGNC=9639|UniProtKB=B0YJ81 B0YJ81 HACD1 PTHR11035:SF22 VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE 1 hydro-lyase activity#GO:0016836;carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;catalytic activity#GO:0003824 small molecule metabolic process#GO:0044281;very long-chain fatty acid metabolic process#GO:0000038;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid biosynthetic process#GO:0046394;oxoacid metabolic process#GO:0043436;lipid biosynthetic process#GO:0008610;fatty acid biosynthetic process#GO:0006633;biosynthetic process#GO:0009058;cellular process#GO:0009987;monocarboxylic acid biosynthetic process#GO:0072330;fatty acid metabolic process#GO:0006631;sphingolipid biosynthetic process#GO:0030148;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283 membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984 dehydratase#PC00091 HUMAN|HGNC=11007|UniProtKB=P11169 P11169 SLC2A3 PTHR23503:SF99 SOLUTE CARRIER FAMILY 2 SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 3 sugar transmembrane transporter activity#GO:0051119;carbohydrate transmembrane transporter activity#GO:0015144;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 cellular process#GO:0009987;D-glucose transmembrane transport#GO:1904659;carbohydrate transmembrane transport#GO:0034219;vitamin transport#GO:0051180;import across plasma membrane#GO:0098739;transport#GO:0006810;carbohydrate transport#GO:0008643;import into cell#GO:0098657;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 secondary carrier transporter#PC00258 HUMAN|HGNC=20964|UniProtKB=A6NIX2 A6NIX2 WTIP PTHR24219:SF6 LIM DOMAIN-CONTAINING PROTEIN JUB WILMS TUMOR PROTEIN 1-INTERACTING PROTEIN transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714 regulatory ncRNA-mediated post-transcriptional gene silencing#GO:0035194;post-transcriptional gene silencing#GO:0016441;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;negative regulation of protein metabolic process#GO:0051248;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of response to stimulus#GO:0048583;regulatory ncRNA-mediated gene silencing#GO:0031047;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of biosynthetic process#GO:0009890;negative regulation of response to stimulus#GO:0048585;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of signaling#GO:0023051;negative regulation of translation#GO:0017148;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of cell communication#GO:0010648;negative regulation of hippo signaling#GO:0035331;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of DNA-templated transcription#GO:0045892;miRNA-mediated post-transcriptional gene silencing#GO:0035195;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of hippo signaling#GO:0035330;negative regulation of metabolic process#GO:0009892;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of protein metabolic process#GO:0051246;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of signal transduction#GO:0009968 intracellular organelle#GO:0043229;P-body#GO:0000932;anchoring junction#GO:0070161;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;organelle#GO:0043226;adherens junction#GO:0005912;membraneless organelle#GO:0043228;cell junction#GO:0030054;nucleus#GO:0005634;cell-cell junction#GO:0005911;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HUMAN|HGNC=1180|UniProtKB=Q15777 Q15777 MPPED2 PTHR12905:SF13 METALLOPHOSPHOESTERASE METALLOPHOSPHOESTERASE MPPED2 phosphoric diester hydrolase activity#GO:0008081;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;cyclic-nucleotide phosphodiesterase activity#GO:0004112;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788 metabolite interconversion enzyme#PC00262;hydrolase#PC00121;esterase#PC00097 HUMAN|HGNC=30410|UniProtKB=Q9BXA6 Q9BXA6 TSSK6 PTHR24343:SF166 SERINE/THREONINE KINASE TESTIS-SPECIFIC SERINE_THREONINE-PROTEIN KINASE 6 protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740 developmental process#GO:0032502;spermatogenesis#GO:0007283;cellular developmental process#GO:0048869;cellular process#GO:0009987;male gamete generation#GO:0048232;spermatid development#GO:0007286;sexual reproduction#GO:0019953;spermatid differentiation#GO:0048515;multicellular organismal reproductive process#GO:0048609;anatomical structure development#GO:0048856;germ cell development#GO:0007281;developmental process involved in reproduction#GO:0003006;reproductive process#GO:0022414;cellular process involved in reproduction in multicellular organism#GO:0022412;cell development#GO:0048468;gamete generation#GO:0007276;cell differentiation#GO:0030154 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=9873|UniProtKB=O95294 O95294 RASAL1 PTHR10194:SF3 RAS GTPASE-ACTIVATING PROTEINS RASGAP-ACTIVATING-LIKE PROTEIN 1 GTPase-activating protein#PC00257 PDGF signaling pathway#P00047>RasGAP#P01152;FGF signaling pathway#P00021>RasGAP#P00646;EGF receptor signaling pathway#P00018>GAP#P00546 HUMAN|HGNC=26811|UniProtKB=Q8N8N0 Q8N8N0 RNF152 PTHR25464:SF1 TRIPARTITE MOTIF-CONTAINING PROTEIN 2-LIKE PROTEIN E3 UBIQUITIN-PROTEIN LIGASE RNF152 acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 positive regulation of cellular process#GO:0048522;response to nutrient levels#GO:0031667;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of response to stimulus#GO:0048585;cellular response to nutrient levels#GO:0031669;regulation of response to stimulus#GO:0048583;cellular response to starvation#GO:0009267;negative regulation of cellular process#GO:0048523;regulation of TORC1 signaling#GO:1903432;regulation of catabolic process#GO:0009894;positive regulation of catabolic process#GO:0009896;cellular response to stimulus#GO:0051716;response to starvation#GO:0042594;regulation of cell communication#GO:0010646;negative regulation of TOR signaling#GO:0032007;regulation of cellular process#GO:0050794;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of TOR signaling#GO:0032006;positive regulation of autophagy#GO:0010508;response to stress#GO:0006950;negative regulation of signal transduction#GO:0009968;cellular response to amino acid starvation#GO:0034198;negative regulation of TORC1 signaling#GO:1904262;regulation of biological process#GO:0050789;regulation of autophagy#GO:0010506;negative regulation of biological process#GO:0048519;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;negative regulation of cell communication#GO:0010648;positive regulation of metabolic process#GO:0009893;negative regulation of intracellular signal transduction#GO:1902532 lysosomal membrane#GO:0005765;membrane#GO:0016020;cytoplasm#GO:0005737;vacuole#GO:0005773;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;vacuolar membrane#GO:0005774;lytic vacuole#GO:0000323;lysosome#GO:0005764;lytic vacuole membrane#GO:0098852;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=10732|UniProtKB=Q92854 Q92854 SEMA4D PTHR11036:SF18 SEMAPHORIN SEMAPHORIN-4D receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;signaling receptor binding#GO:0005102;binding#GO:0005488;molecular function activator activity#GO:0140677;protein binding#GO:0005515 anatomical structure development#GO:0048856;cell communication#GO:0007154;regulation of cell motility#GO:2000145;system development#GO:0048731;chemotaxis#GO:0006935;regulation of cellular process#GO:0050794;locomotion#GO:0040011;cellular response to stimulus#GO:0051716;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;neuron projection guidance#GO:0097485;positive regulation of locomotion#GO:0040017;response to external stimulus#GO:0009605;neuron projection morphogenesis#GO:0048812;regulation of cell migration#GO:0030334;developmental process#GO:0032502;multicellular organismal process#GO:0032501;regulation of locomotion#GO:0040012;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;axon guidance#GO:0007411;axon development#GO:0061564;positive regulation of cell migration#GO:0030335;positive regulation of cellular process#GO:0048522;axonogenesis#GO:0007409;neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;cell morphogenesis#GO:0000902;response to stimulus#GO:0050896;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell development#GO:0048468;signaling#GO:0023052;cellular component organization#GO:0016043;positive regulation of cell motility#GO:2000147;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cell projection morphogenesis#GO:0048858;cell surface receptor signaling pathway#GO:0007166;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;taxis#GO:0042330;response to chemical#GO:0042221;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;neuron projection development#GO:0031175;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165 membrane#GO:0016020;extracellular region#GO:0005576;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 membrane-bound signaling molecule#PC00152 Axon guidance mediated by semaphorins#P00007>Sema4D#P00329 HUMAN|HGNC=14106|UniProtKB=Q9HCU8 Q9HCU8 POLD4 PTHR14303:SF0 DNA POLYMERASE DELTA SUBUNIT 4 DNA POLYMERASE DELTA SUBUNIT 4 DNA-directed DNA polymerase activity#GO:0003887;DNA polymerase activity#GO:0034061;catalytic activity, acting on DNA#GO:0140097;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772 metabolic process#GO:0008152;DNA repair#GO:0006281;nucleobase-containing compound biosynthetic process#GO:0034654;DNA metabolic process#GO:0006259;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;response to stress#GO:0006950;DNA biosynthetic process#GO:0071897;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;nucleic acid biosynthetic process#GO:0141187;cellular response to stress#GO:0033554;DNA-templated DNA replication#GO:0006261;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular response to stimulus#GO:0051716;DNA replication#GO:0006260;response to stimulus#GO:0050896 intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234;DNA polymerase complex#GO:0042575;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;protein-DNA complex#GO:0032993;replication fork#GO:0005657;replisome#GO:0030894;organelle lumen#GO:0043233;chromosome#GO:0005694;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;nuclear replication fork#GO:0043596 DNA metabolism protein#PC00009;DNA-directed DNA polymerase#PC00018 HUMAN|HGNC=25471|UniProtKB=Q5MNZ9 Q5MNZ9 WIPI1 PTHR11227:SF23 WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED WD REPEAT DOMAIN PHOSPHOINOSITIDE-INTERACTING PROTEIN 1 small molecule binding#GO:0036094;binding#GO:0005488;anion binding#GO:0043168;protein-macromolecule adaptor activity#GO:0030674;ion binding#GO:0043167;phosphatidylinositol bisphosphate binding#GO:1902936;lipid binding#GO:0008289;phospholipid binding#GO:0005543;molecular adaptor activity#GO:0060090;phosphatidylinositol phosphate binding#GO:1901981;phosphatidylinositol-3-phosphate binding#GO:0032266 cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;autophagosome organization#GO:1905037;autophagy#GO:0006914;cellular component organization or biogenesis#GO:0071840;autophagosome assembly#GO:0000045;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;polysaccharide metabolic process#GO:0005976;glucan catabolic process#GO:0009251;cellular component organization#GO:0016043;glucan metabolic process#GO:0044042;polysaccharide catabolic process#GO:0000272;carbohydrate catabolic process#GO:0016052;process utilizing autophagic mechanism#GO:0061919;macroautophagy#GO:0016236;macromolecule localization#GO:0033036;glycogen catabolic process#GO:0005980;energy derivation by oxidation of organic compounds#GO:0015980;pexophagy#GO:0000425;macromolecule metabolic process#GO:0043170;intracellular protein localization#GO:0008104;autophagy of mitochondrion#GO:0000422;generation of precursor metabolites and energy#GO:0006091;catabolic process#GO:0009056;carbohydrate metabolic process#GO:0005975;primary metabolic process#GO:0044238;glycogen metabolic process#GO:0005977;localization#GO:0051179;vacuole organization#GO:0007033;organelle assembly#GO:0070925;energy reserve metabolic process#GO:0006112 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;phagophore assembly site#GO:0000407 scaffold/adaptor protein#PC00226 HUMAN|HGNC=13169|UniProtKB=P35789 P35789 ZNF93 PTHR24377:SF407 IP01015P-RELATED ZINC FINGER PROTEIN 93 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=5135|UniProtKB=P35452 P35452 HOXD12 PTHR46440:SF1 HOMEOBOX PROTEIN HOX-D12-RELATED HOMEOBOX PROTEIN HOX-D12 DNA binding#GO:0003677;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;binding#GO:0005488 homeodomain transcription factor#PC00119 HUMAN|HGNC=23679|UniProtKB=Q5T953 Q5T953 IER5L PTHR15895:SF14 IMMEDIATE EARLY RESPONSE GENE IMMEDIATE EARLY RESPONSE GENE 5-LIKE PROTEIN HUMAN|HGNC=26209|UniProtKB=Q8N3Z6 Q8N3Z6 ZCCHC7 PTHR46543:SF1 ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7 ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 RNA metabolic process#GO:0016070;RNA catabolic process#GO:0006401;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;tRNA metabolic process#GO:0006399;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;snRNA metabolic process#GO:0016073;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;macromolecule metabolic process#GO:0043170;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;nuclear mRNA surveillance#GO:0071028;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;nucleobase-containing compound catabolic process#GO:0034655;nucleic acid catabolic process#GO:0141188;negative regulation of macromolecule metabolic process#GO:0010605 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229 HUMAN|HGNC=26994|UniProtKB=Q6PI98 Q6PI98 INO80C PTHR31200:SF1 INO80 COMPLEX SUBUNIT C INO80 COMPLEX SUBUNIT C cellular process#GO:0009987;cellular component organization#GO:0016043;chromatin organization#GO:0006325;chromatin remodeling#GO:0006338;cellular component organization or biogenesis#GO:0071840 nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;Ino80 complex#GO:0031011;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;chromatin#GO:0000785;INO80-type complex#GO:0097346;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ATPase complex#GO:1904949;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;organelle lumen#GO:0043233;SWI/SNF superfamily-type complex#GO:0070603 HUMAN|HGNC=17103|UniProtKB=Q9Y5L0 Q9Y5L0 TNPO3 PTHR12363:SF42 TRANSPORTIN 3 AND IMPORTIN 13 TRANSPORTIN-3 molecular carrier activity#GO:0140104;nucleocytoplasmic carrier activity#GO:0140142 macromolecule localization#GO:0033036;import into nucleus#GO:0051170;protein localization to nucleus#GO:0034504;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;intracellular transport#GO:0046907;transport#GO:0006810;intracellular protein transport#GO:0006886;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;protein localization to organelle#GO:0033365;nucleocytoplasmic transport#GO:0006913;localization#GO:0051179;cellular localization#GO:0051641;nuclear transport#GO:0051169;protein transport#GO:0015031;protein import into nucleus#GO:0006606 nucleus#GO:0005634;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 transporter#PC00227 HUMAN|HGNC=945|UniProtKB=O60242 O60242 ADGRB3 PTHR12011:SF40 ADHESION G-PROTEIN COUPLED RECEPTOR ADHESION G PROTEIN-COUPLED RECEPTOR B3 signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 developmental process#GO:0032502;neuron differentiation#GO:0030182;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;cell maturation#GO:0048469;multicellular organism development#GO:0007275;cellular process#GO:0009987;signal transduction#GO:0007165;nervous system development#GO:0007399;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;developmental maturation#GO:0021700;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;G protein-coupled receptor signaling pathway#GO:0007186;neuron development#GO:0048666;system development#GO:0048731;anatomical structure development#GO:0048856;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;anatomical structure maturation#GO:0071695;regulation of biological process#GO:0050789;cell development#GO:0048468;signaling#GO:0023052;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;response to stimulus#GO:0050896 cell periphery#GO:0071944;membrane#GO:0016020;postsynapse#GO:0098794;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;synapse#GO:0045202;extracellular region#GO:0005576;cell junction#GO:0030054 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 p53 pathway#P00059>BAI-1#G04699 HUMAN|HGNC=35454|UniProtKB=Q19T08 Q19T08 ECSCR PTHR28602:SF1 ENDOTHELIAL CELL-SPECIFIC CHEMOTAXIS REGULATOR ENDOTHELIAL CELL-SPECIFIC CHEMOTAXIS REGULATOR regulation of multicellular organismal development#GO:2000026;regulation of biological process#GO:0050789;negative regulation of multicellular organismal process#GO:0051241;positive regulation of proteasomal protein catabolic process#GO:1901800;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;regulation of developmental process#GO:0050793;positive regulation of programmed cell death#GO:0043068;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of protein metabolic process#GO:0051247;regulation of angiogenesis#GO:0045765;regulation of protein catabolic process#GO:0042176;positive regulation of protein catabolic process#GO:0045732;positive regulation of metabolic process#GO:0009893;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;regulation of proteasomal protein catabolic process#GO:0061136;positive regulation of macromolecule metabolic process#GO:0010604;regulation of apoptotic process#GO:0042981;regulation of vasculature development#GO:1901342;regulation of catabolic process#GO:0009894;negative regulation of angiogenesis#GO:0016525;regulation of anatomical structure morphogenesis#GO:0022603;positive regulation of catabolic process#GO:0009896;positive regulation of apoptotic process#GO:0043065 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886;membrane#GO:0016020;cytosol#GO:0005829;cell periphery#GO:0071944 HUMAN|HGNC=19833|UniProtKB=Q7Z6M2 Q7Z6M2 FBXO33 PTHR20933:SF3 F-BOX ONLY PROTEIN 33 F-BOX ONLY PROTEIN 33 regulation of protein modification by small protein conjugation or removal#GO:1903320;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of protein metabolic process#GO:0051247;positive regulation of metabolic process#GO:0009893;regulation of post-translational protein modification#GO:1901873;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;regulation of primary metabolic process#GO:0080090;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of protein ubiquitination#GO:0031398;positive regulation of macromolecule metabolic process#GO:0010604;biological regulation#GO:0065007;regulation of protein ubiquitination#GO:0031396;regulation of protein modification process#GO:0031399 HUMAN|HGNC=26485|UniProtKB=Q96MR6 Q96MR6 CFAP57 PTHR32215:SF0 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 57 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 57 structural protein#PC00211 HUMAN|HGNC=25635|UniProtKB=Q8IYT2 Q8IYT2 CMTR2 PTHR16121:SF2 CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1-RELATED CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 2 RNA methyltransferase activity#GO:0008173;catalytic activity, acting on RNA#GO:0140098;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity#GO:0016740;catalytic activity#GO:0003824;methyltransferase activity#GO:0008168;O-methyltransferase activity#GO:0008171 mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 HUMAN|HGNC=548|UniProtKB=P28039 P28039 AOAH PTHR15010:SF0 ACYLOXYACYL HYDROLASE ACYLOXYACYL HYDROLASE catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;carboxylic ester hydrolase activity#GO:0052689;calcium ion binding#GO:0005509;metal ion binding#GO:0046872;hydrolase activity#GO:0016787;cation binding#GO:0043169 primary metabolic process#GO:0044238;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of defense response#GO:0031348;negative regulation of inflammatory response#GO:0050728;catabolic process#GO:0009056;liposaccharide metabolic process#GO:1903509;carbohydrate derivative catabolic process#GO:1901136;regulation of defense response#GO:0031347;regulation of inflammatory response#GO:0050727;lipopolysaccharide metabolic process#GO:0008653;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;lipid catabolic process#GO:0016042;negative regulation of response to stimulus#GO:0048585;regulation of response to external stimulus#GO:0032101;biological regulation#GO:0065007;negative regulation of response to external stimulus#GO:0032102;macromolecule catabolic process#GO:0009057;regulation of response to stress#GO:0080134;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;regulation of response to stimulus#GO:0048583;macromolecule metabolic process#GO:0043170 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HUMAN|HGNC=2522|UniProtKB=Q6GPI1 Q6GPI1 CTRB2 PTHR24250:SF53 CHYMOTRYPSIN-RELATED CHYMOTRYPSINOGEN B2 catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;serine-type peptidase activity#GO:0008236 proteolysis#GO:0006508;metabolic process#GO:0008152;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 protein modifying enzyme#PC00260;serine protease#PC00203 HUMAN|HGNC=25913|UniProtKB=Q96K49 Q96K49 TMEM87B PTHR21229:SF16 LUNG SEVEN TRANSMEMBRANE RECEPTOR TRANSMEMBRANE PROTEIN 87B intracellular transport#GO:0046907;transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;endosomal transport#GO:0016197;retrograde transport, endosome to Golgi#GO:0042147;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;cytosolic transport#GO:0016482 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=208|UniProtKB=Q9UKF2 Q9UKF2 ADAM30 PTHR11905:SF148 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 30 metalloendopeptidase activity#GO:0004222;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 developmental process#GO:0032502;development of primary sexual characteristics#GO:0045137;male sex differentiation#GO:0046661;metabolic process#GO:0008152;development of primary male sexual characteristics#GO:0046546;multicellular organism development#GO:0007275;macromolecule metabolic process#GO:0043170;animal organ development#GO:0048513;male gonad development#GO:0008584;cellular process#GO:0009987;sex differentiation#GO:0007548;gonad development#GO:0008406;multicellular organismal process#GO:0032501;proteolysis#GO:0006508;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;reproductive system development#GO:0061458;protein metabolic process#GO:0019538;anatomical structure development#GO:0048856;primary metabolic process#GO:0044238;developmental process involved in reproduction#GO:0003006;reproductive structure development#GO:0048608;reproductive process#GO:0022414 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;cell surface#GO:0009986;external side of plasma membrane#GO:0009897;side of membrane#GO:0098552 metalloprotease#PC00153;protease#PC00190 HUMAN|HGNC=11458|UniProtKB=Q06520 Q06520 SULT2A1 PTHR11783:SF8 SULFOTRANSFERASE SULT SULFOTRANSFERASE 2A1 sulfotransferase activity#GO:0008146;transferase activity, transferring sulphur-containing groups#GO:0016782;transferase activity#GO:0016740;catalytic activity#GO:0003824 cellular process#GO:0009987;metabolic process#GO:0008152;sulfur compound metabolic process#GO:0006790 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;transferase#PC00220 HUMAN|HGNC=7197|UniProtKB=Q16653 Q16653 MOG PTHR24100:SF71 BUTYROPHILIN MYELIN-OLIGODENDROCYTE GLYCOPROTEIN protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;T cell receptor signaling pathway#GO:0050852;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of cytokine production#GO:0001817;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;positive regulation of response to stimulus#GO:0048584;regulation of immune response#GO:0050776;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;immune response-activating cell surface receptor signaling pathway#GO:0002429;regulation of macromolecule metabolic process#GO:0060255;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;immune response-activating signaling pathway#GO:0002757;activation of immune response#GO:0002253;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;positive regulation of immune system process#GO:0002684;regulation of multicellular organismal process#GO:0051239;antigen receptor-mediated signaling pathway#GO:0050851;immune system process#GO:0002376;regulation of biological process#GO:0050789;immune response-regulating signaling pathway#GO:0002764;signaling#GO:0023052;response to stimulus#GO:0050896 plasma membrane#GO:0005886;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=2615|UniProtKB=P20813 P20813 CYP2B6 PTHR24300:SF406 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 2B6 oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen#GO:0016712;catalytic activity#GO:0003824;monooxygenase activity#GO:0004497;heme binding#GO:0020037;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;tetrapyrrole binding#GO:0046906;binding#GO:0005488 monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;arachidonate metabolic process#GO:0019369;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;xenobiotic metabolic process#GO:0006805;response to xenobiotic stimulus#GO:0009410;cellular response to chemical stimulus#GO:0070887;oxoacid metabolic process#GO:0043436;olefinic compound metabolic process#GO:0120254;long-chain fatty acid metabolic process#GO:0001676;cellular process#GO:0009987;response to chemical#GO:0042221;icosanoid metabolic process#GO:0006690;cellular response to xenobiotic stimulus#GO:0071466;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;unsaturated fatty acid metabolic process#GO:0033559;lipid metabolic process#GO:0006629 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229 oxidoreductase#PC00176;oxygenase#PC00177 Bupropion degradation#P05729>Cytochrome P450 2B6#P05742 HUMAN|HGNC=11330|UniProtKB=P30872 P30872 SSTR1 PTHR24229:SF38 NEUROPEPTIDES RECEPTOR SOMATOSTATIN RECEPTOR TYPE 1 signaling receptor activity#GO:0038023;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;neuropeptide binding#GO:0042923;peptide binding#GO:0042277;transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;neuropeptide receptor activity#GO:0008188;binding#GO:0005488 biological regulation#GO:0065007;response to estradiol#GO:0032355;response to chemical#GO:0042221;response to lipid#GO:0033993;cellular response to lipid#GO:0071396;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;cellular process#GO:0009987;cell communication#GO:0007154;response to oxygen-containing compound#GO:1901700;G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;neuropeptide signaling pathway#GO:0007218 membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005;cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;cell projection#GO:0042995 G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GsPCR#P00720;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GoPCR#P00725 HUMAN|HGNC=967|UniProtKB=Q9BXC9 Q9BXC9 BBS2 PTHR32465:SF0 BARDET-BIEDL SYNDROME 2 PROTEIN BBSOME COMPLEX MEMBER BBS2 plasma membrane bounded cell projection assembly#GO:0120031;organelle assembly#GO:0070925;cilium organization#GO:0044782;cellular component organization or biogenesis#GO:0071840;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular component organization#GO:0016043;cilium assembly#GO:0060271;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cell projection organization#GO:0030030 cellular anatomical structure#GO:0110165;organelle#GO:0043226;motile cilium#GO:0031514;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cilium#GO:0005929;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;BBSome#GO:0034464;intracellular membraneless organelle#GO:0043232;membrane#GO:0016020;microtubule cytoskeleton#GO:0015630;neuron projection#GO:0043005;membraneless organelle#GO:0043228;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815 HUMAN|HGNC=890|UniProtKB=Q13825 Q13825 AUH PTHR11941:SF12 ENOYL-COA HYDRATASE-RELATED METHYLGLUTACONYL-COA HYDRATASE, MITOCHONDRIAL catalytic activity#GO:0003824;hydro-lyase activity#GO:0016836;carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829 monocarboxylic acid catabolic process#GO:0072329;lipid catabolic process#GO:0016042;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;lipid modification#GO:0030258;fatty acid oxidation#GO:0019395;fatty acid beta-oxidation#GO:0006635;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;small molecule catabolic process#GO:0044282;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;fatty acid catabolic process#GO:0009062;lipid oxidation#GO:0034440;oxoacid metabolic process#GO:0043436 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;lyase#PC00144;hydratase#PC00120 HUMAN|HGNC=16445|UniProtKB=Q96LJ7 Q96LJ7 DHRS1 PTHR44147:SF2 DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 1 DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 1 catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;oxidoreductase activity#GO:0016491;alcohol dehydrogenase (NADP+) activity#GO:0008106;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HUMAN|HGNC=14388|UniProtKB=Q9HCN6 Q9HCN6 GP6 PTHR11738:SF185 MHC CLASS I NK CELL RECEPTOR PLATELET GLYCOPROTEIN VI molecular transducer activity#GO:0060089;immune receptor activity#GO:0140375;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;immune response-regulating signaling pathway#GO:0002764;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;signaling#GO:0023052;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of immune response#GO:0050776;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=11243|UniProtKB=Q9Y657 Q9Y657 SPIN1 PTHR10405:SF15 SPINDLIN SPINDLIN-1 histone H3 reader activity#GO:0140006;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;histone reader activity#GO:0140566;chromatin-protein adaptor activity#GO:0140463 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=17756|UniProtKB=Q9HAV5 Q9HAV5 EDA2R PTHR12120:SF8 TNFR-CYS DOMAIN-CONTAINING PROTEIN TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 27 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;biological regulation#GO:0065007;signaling#GO:0023052;response to chemical#GO:0042221;response to stimulus#GO:0050896;response to cytokine#GO:0034097;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;cytokine-mediated signaling pathway#GO:0019221;response to peptide#GO:1901652;cell communication#GO:0007154 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 HUMAN|HGNC=28184|UniProtKB=Q9BRQ6 Q9BRQ6 CHCHD6 PTHR47609:SF1 MICOS COMPLEX SUBUNIT MIC25 MICOS COMPLEX SUBUNIT MIC25 cellular component organization or biogenesis#GO:0071840;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;response to stimulus#GO:0050896;mitochondrion organization#GO:0007005;membrane organization#GO:0061024;organelle organization#GO:0006996;cellular component organization#GO:0016043;response to stress#GO:0006950;mitochondrial membrane organization#GO:0007006;cellular process#GO:0009987;inner mitochondrial membrane organization#GO:0007007;cellular response to stimulus#GO:0051716 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739 HUMAN|HGNC=30565|UniProtKB=O14562 O14562 UBFD1 PTHR16470:SF0 UBIQUITIN DOMAIN-CONTAINING PROTEIN UBFD1 UBIQUITIN DOMAIN-CONTAINING PROTEIN UBFD1 HUMAN|HGNC=640|UniProtKB=O14520 O14520 AQP7 PTHR43829:SF15 AQUAPORIN OR AQUAGLYCEROPORIN RELATED AQUAPORIN-7 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;water transmembrane transporter activity#GO:0005372;water channel activity#GO:0015250;passive transmembrane transporter activity#GO:0022803;carbohydrate transmembrane transporter activity#GO:0015144;channel activity#GO:0015267 localization#GO:0051179;water transport#GO:0006833;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;fluid transport#GO:0042044;organic hydroxy compound transport#GO:0015850;carbohydrate transport#GO:0008643;transport#GO:0006810;carbohydrate transmembrane transport#GO:0034219;cellular process#GO:0009987 plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;basolateral plasma membrane#GO:0016323;basal part of cell#GO:0045178;membrane#GO:0016020;basal plasma membrane#GO:0009925;cell periphery#GO:0071944 transporter#PC00227 HUMAN|HGNC=15570|UniProtKB=Q6UW49 Q6UW49 SPESP1 PTHR31667:SF2 SPERM EQUATORIAL SEGMENT PROTEIN 1 SPERM EQUATORIAL SEGMENT PROTEIN 1 fertilization#GO:0009566;reproductive process#GO:0022414;cellular process involved in reproduction in multicellular organism#GO:0022412;cellular process#GO:0009987;acrosome reaction#GO:0007340;fusion of sperm to egg plasma membrane involved in single fertilization#GO:0007342;single fertilization#GO:0007338;multicellular organismal reproductive process#GO:0048609;sexual reproduction#GO:0019953 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;secretory vesicle#GO:0099503;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;acrosomal vesicle#GO:0001669;intracellular organelle#GO:0043229 HUMAN|HGNC=11811|UniProtKB=O14901 O14901 KLF11 PTHR23235:SF65 KRUEPPEL-LIKE TRANSCRIPTION FACTOR KRUEPPEL-LIKE FACTOR 11 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=3359|UniProtKB=Q9Y6X5 Q9Y6X5 ENPP4 PTHR10151:SF79 ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE BIS(5'-ADENOSYL)-TRIPHOSPHATASE ENPP4 hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824 hydrolase#PC00121;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=18016|UniProtKB=Q8WUM0 Q8WUM0 NUP133 PTHR13405:SF11 NUCLEAR PORE COMPLEX PROTEIN NUP133 NUCLEAR PORE COMPLEX PROTEIN NUP133 structural molecule activity#GO:0005198;structural constituent of nuclear pore#GO:0017056 nucleic acid transport#GO:0050657;localization#GO:0051179;nuclear export#GO:0051168;nuclear transport#GO:0051169;nucleocytoplasmic transport#GO:0006913;RNA localization#GO:0006403;transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery#GO:0000972;protein localization to organelle#GO:0033365;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;establishment of RNA localization#GO:0051236;mRNA transport#GO:0051028;establishment of localization#GO:0051234;poly(A)+ mRNA export from nucleus#GO:0016973;macromolecule metabolic process#GO:0043170;establishment of protein localization to organelle#GO:0072594;chromosome organization#GO:0051276;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;transport#GO:0006810;biosynthetic process#GO:0009058;protein localization to nucleus#GO:0034504;nitrogen compound transport#GO:0071705;import into nucleus#GO:0051170;macromolecule localization#GO:0033036;macromolecule biosynthetic process#GO:0009059;mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;protein import into nucleus#GO:0006606;protein transport#GO:0015031;cellular component organization#GO:0016043;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;intracellular protein transport#GO:0006886;gene expression#GO:0010467;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184 nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;nuclear pore outer ring#GO:0031080;nucleus#GO:0005634;organelle envelope#GO:0031967;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear pore#GO:0005643;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229 HUMAN|HGNC=12786|UniProtKB=O00755 O00755 WNT7A PTHR12027:SF78 WNT RELATED PROTEIN WNT-7A protein binding#GO:0005515;molecular function activator activity#GO:0140677;binding#GO:0005488;signaling receptor binding#GO:0005102;cytokine activity#GO:0005125;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;frizzled binding#GO:0005109;G protein-coupled receptor binding#GO:0001664 positive regulation of signaling#GO:0023056;cell fate commitment#GO:0045165;animal gross anatomical part developmental process#GO:0160108;positive regulation of JNK cascade#GO:0046330;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;generation of neurons#GO:0048699;cell differentiation#GO:0030154;response to stimulus#GO:0050896;signaling#GO:0023052;regulation of biological process#GO:0050789;regulation of JNK cascade#GO:0046328;multicellular organism development#GO:0007275;cell surface receptor signaling pathway#GO:0007166;regulation of MAPK cascade#GO:0043408;neuron differentiation#GO:0030182;nervous system development#GO:0007399;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;anatomical structure development#GO:0048856;canonical Wnt signaling pathway#GO:0060070;cell communication#GO:0007154;system development#GO:0048731;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;Wnt signaling pathway#GO:0016055;regulation of cell communication#GO:0010646;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;positive regulation of MAPK cascade#GO:0043410;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;developmental process#GO:0032502;multicellular organismal process#GO:0032501;positive regulation of response to stimulus#GO:0048584;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of cellular process#GO:0048522 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 Angiogenesis#P00005>Wnt#P00206;Cadherin signaling pathway#P00012>Wnt#P00474;Alzheimer disease-presenilin pathway#P00004>Wnt#P00142;Wnt signaling pathway#P00057>Wnt#P01444 HUMAN|HGNC=33876|UniProtKB=P0CV98 P0CV98 TSPY3 PTHR11875:SF12 TESTIS-SPECIFIC Y-ENCODED PROTEIN TESTIS-SPECIFIC Y-ENCODED PROTEIN 1-RELATED histone binding#GO:0042393;chromatin binding#GO:0003682;binding#GO:0005488;protein binding#GO:0005515 chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=17855|UniProtKB=O94923 O94923 GLCE PTHR13174:SF3 D-GLUCURONYL C5-EPIMERASE D-GLUCURONYL C5-EPIMERASE isomerase activity#GO:0016853;catalytic activity#GO:0003824;racemase and epimerase activity, acting on carbohydrates and derivatives#GO:0016857;racemase and epimerase activity#GO:0016854 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein O-linked glycosylation#GO:0006493;carbohydrate derivative metabolic process#GO:1901135;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;biosynthetic process#GO:0009058;proteoglycan biosynthetic process#GO:0030166;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;proteoglycan metabolic process#GO:0006029;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 isomerase#PC00135 HUMAN|HGNC=9905|UniProtKB=Q9Y5S9 Q9Y5S9 RBM8A PTHR45894:SF1 RNA-BINDING PROTEIN 8A RNA-BINDING PROTEIN 8A RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676 metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleic acid biosynthetic process#GO:0141187;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;RNA biosynthetic process#GO:0032774;nucleobase-containing compound metabolic process#GO:0006139 organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;exon-exon junction complex#GO:0035145;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=3665|UniProtKB=P05230 P05230 FGF1 PTHR11486:SF86 FIBROBLAST GROWTH FACTOR FIBROBLAST GROWTH FACTOR 1 signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;fibroblast growth factor receptor binding#GO:0005104;growth factor receptor binding#GO:0070851;growth factor activity#GO:0008083;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;molecular function activator activity#GO:0140677;protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488 animal gross anatomical part developmental process#GO:0160108;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;cellular response to growth factor stimulus#GO:0071363;positive regulation of cell population proliferation#GO:0008284;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;cell differentiation#GO:0030154;signaling#GO:0023052;cell surface receptor signaling pathway#GO:0007166;regulation of MAPK cascade#GO:0043408;multicellular organism development#GO:0007275;cellular response to fibroblast growth factor stimulus#GO:0044344;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;nervous system development#GO:0007399;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of cell population proliferation#GO:0042127;cell communication#GO:0007154;regulation of cell motility#GO:2000145;system development#GO:0048731;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;response to growth factor#GO:0070848;regulation of cell communication#GO:0010646;response to fibroblast growth factor#GO:0071774;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;developmental process#GO:0032502;regulation of cell migration#GO:0030334;positive regulation of MAPK cascade#GO:0043410;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;positive regulation of cellular process#GO:0048522;multicellular organismal process#GO:0032501;fibroblast growth factor receptor signaling pathway#GO:0008543;positive regulation of response to stimulus#GO:0048584;regulation of locomotion#GO:0040012;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;extracellular region#GO:0005576 growth factor#PC00112;intercellular signal molecule#PC00207 Angiogenesis#P00005>FGF#P00213;FGF signaling pathway#P00021>FGF#P00623 HUMAN|HGNC=24548|UniProtKB=Q96IY1 Q96IY1 NSL1 PTHR31749:SF3 KINETOCHORE-ASSOCIATED PROTEIN NSL1 HOMOLOG KINETOCHORE-ASSOCIATED PROTEIN NSL1 HOMOLOG condensed chromosome#GO:0000793;chromosome, centromeric region#GO:0000775;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;outer kinetochore#GO:0000940;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;condensed chromosome, centromeric region#GO:0000779;chromosome#GO:0005694;kinetochore#GO:0000776;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232 HUMAN|HGNC=24293|UniProtKB=Q70JA7 Q70JA7 CHSY3 PTHR12369:SF40 CHONDROITIN SYNTHASE CHONDROITIN SULFATE SYNTHASE 3 glycosyltransferase activity#GO:0016757;acetylgalactosaminyltransferase activity#GO:0008376;UDP-glycosyltransferase activity#GO:0008194;transferase activity#GO:0016740;glucuronosyltransferase activity#GO:0015020;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;proteoglycan metabolic process#GO:0006029;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;carbohydrate derivative metabolic process#GO:1901135;protein O-linked glycosylation#GO:0006493;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;chondroitin sulfate proteoglycan metabolic process#GO:0050654;glycoprotein biosynthetic process#GO:0009101;proteoglycan biosynthetic process#GO:0030166;biosynthetic process#GO:0009058;chondroitin sulfate proteoglycan biosynthetic process#GO:0050650 glycosyltransferase#PC00111 HUMAN|HGNC=18079|UniProtKB=Q5T0B9 Q5T0B9 ZNF362 PTHR24390:SF230 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 362 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 DNA-binding transcription factor#PC00218;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=28730|UniProtKB=Q86XU0 Q86XU0 ZNF677 PTHR24377:SF698 IP01015P-RELATED ZINC FINGER PROTEIN 677 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=17821|UniProtKB=O00148 O00148 DDX39A PTHR47958:SF10 ATP-DEPENDENT RNA HELICASE DBP3 ATP-DEPENDENT RNA HELICASE DDX39A mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488;ATP-dependent activity#GO:0140657;RNA binding#GO:0003723;nucleic acid conformation isomerase activity#GO:0120545;RNA helicase activity#GO:0003724;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543;helicase activity#GO:0004386;isomerase activity#GO:0016853;catalytic activity, acting on RNA#GO:0140098 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA transport#GO:0051028;RNA biosynthetic process#GO:0032774;establishment of RNA localization#GO:0051236;nucleobase-containing compound transport#GO:0015931;RNA transport#GO:0050658;RNA localization#GO:0006403;nucleocytoplasmic transport#GO:0006913;RNA splicing, via transesterification reactions#GO:0000375;nuclear transport#GO:0051169;nuclear export#GO:0051168;localization#GO:0051179;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;nucleic acid transport#GO:0050657;macromolecule biosynthetic process#GO:0009059;macromolecule localization#GO:0033036;nitrogen compound transport#GO:0071705;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;transport#GO:0006810;RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907;macromolecule metabolic process#GO:0043170;establishment of localization#GO:0051234;mRNA splicing, via spliceosome#GO:0000398;mRNA metabolic process#GO:0016071;nucleic acid biosynthetic process#GO:0141187;mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;RNA metabolic process#GO:0016070;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;mRNA processing#GO:0006397;RNA processing#GO:0006396;gene expression#GO:0010467;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654 RNA helicase#PC00032 HUMAN|HGNC=3775|UniProtKB=Q06787 Q06787 FMR1 PTHR10603:SF4 FRAGILE X MENTAL RETARDATION SYNDROME-RELATED PROTEIN FRAGILE X MESSENGER RIBONUCLEOPROTEIN 1 mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723;mRNA 3'-UTR binding#GO:0003730 regulation of signaling#GO:0023051;positive regulation of protein metabolic process#GO:0051247;animal gross anatomical part developmental process#GO:0160108;regulation of biological quality#GO:0065008;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of multicellular organismal process#GO:0051240;regulation of multicellular organismal development#GO:2000026;regulation of biological process#GO:0050789;regulation of mRNA catabolic process#GO:0061013;regulation of mRNA stability#GO:0043488;positive regulation of nervous system development#GO:0051962;positive regulation of cell differentiation#GO:0045597;animal organ development#GO:0048513;regulation of mRNA metabolic process#GO:1903311;positive regulation of biological process#GO:0048518;regulation of protein metabolic process#GO:0051246;positive regulation of cell development#GO:0010720;regulation of multicellular organismal process#GO:0051239;regulation of trans-synaptic signaling#GO:0099177;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA stability#GO:0043487;regulation of RNA metabolic process#GO:0051252;positive regulation of translation#GO:0045727;anatomical structure development#GO:0048856;regulation of nervous system development#GO:0051960;nucleic acid transport#GO:0050657;positive regulation of biosynthetic process#GO:0009891;localization#GO:0051179;regulation of neurogenesis#GO:0050767;positive regulation of neurogenesis#GO:0050769;regulation of cell communication#GO:0010646;modulation of chemical synaptic transmission#GO:0050804;establishment of RNA localization#GO:0051236;regulation of developmental process#GO:0050793;mRNA transport#GO:0051028;RNA transport#GO:0050658;regulation of cellular process#GO:0050794;RNA localization#GO:0006403;nucleobase-containing compound transport#GO:0015931;regulation of macromolecule metabolic process#GO:0060255;transport#GO:0006810;regulation of cell differentiation#GO:0045595;developmental process#GO:0032502;positive regulation of developmental process#GO:0051094;post-transcriptional regulation of gene expression#GO:0010608;regulation of synaptic plasticity#GO:0048167;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;positive regulation of gene expression#GO:0010628;establishment of localization#GO:0051234;regulation of biosynthetic process#GO:0009889;regulation of neuronal synaptic plasticity#GO:0048168;regulation of cell development#GO:0060284;positive regulation of cellular process#GO:0048522;nitrogen compound transport#GO:0071705;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;macromolecule localization#GO:0033036;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;membraneless organelle#GO:0043228;cytoplasmic stress granule#GO:0010494;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;neuron projection#GO:0043005;nucleus#GO:0005634 translation factor#PC00223;translational protein#PC00263 HUMAN|HGNC=18200|UniProtKB=Q8WXE0 Q8WXE0 CASKIN2 PTHR24174:SF18 ANKYRIN REPEAT AND STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 1 CASKIN-2 cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052 scaffold/adaptor protein#PC00226 HUMAN|HGNC=6000|UniProtKB=P18510 P18510 IL1RN PTHR10078:SF28 INTERLEUKIN-1 FAMILY MEMBER INTERLEUKIN-1 RECEPTOR ANTAGONIST PROTEIN cytokine activity#GO:0005125;signaling receptor binding#GO:0005102;cytokine receptor binding#GO:0005126;binding#GO:0005488;molecular function inhibitor activity#GO:0140678;molecular function activator activity#GO:0140677;signaling receptor inhibitor activity#GO:0030547;protein binding#GO:0005515;growth factor binding#GO:0019838;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;cytokine binding#GO:0019955 regulation of cellular process#GO:0050794;response to external biotic stimulus#GO:0043207;negative regulation of response to cytokine stimulus#GO:0060761;regulation of cell communication#GO:0010646;cellular response to biotic stimulus#GO:0071216;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;cytokine-mediated signaling pathway#GO:0019221;response to bacterium#GO:0009617;inflammatory response#GO:0006954;negative regulation of response to stimulus#GO:0048585;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;response to other organism#GO:0051707;immune response#GO:0006955;cellular response to molecule of bacterial origin#GO:0071219;response to external stimulus#GO:0009605;defense response#GO:0006952;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;response to molecule of bacterial origin#GO:0002237;cellular response to cytokine stimulus#GO:0071345;negative regulation of cell communication#GO:0010648;response to peptide#GO:1901652;cellular response to chemical stimulus#GO:0070887;immune system process#GO:0002376;negative regulation of signaling#GO:0023057;response to oxygen-containing compound#GO:1901700;regulation of signaling#GO:0023051;response to cytokine#GO:0034097;response to chemical#GO:0042221;cellular response to lipid#GO:0071396;response to lipid#GO:0033993;negative regulation of signal transduction#GO:0009968;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;cellular response to lipopolysaccharide#GO:0071222;regulation of response to cytokine stimulus#GO:0060759;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987;regulation of cytokine-mediated signaling pathway#GO:0001959;response to lipopolysaccharide#GO:0032496;negative regulation of cytokine-mediated signaling pathway#GO:0001960;cell surface receptor signaling pathway#GO:0007166 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207;interleukin superfamily#PC00128;cytokine#PC00083 HUMAN|HGNC=51246|UniProtKB=B9A6J9 B9A6J9 TBC1D3L PTHR22957:SF571 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN TBC1 DOMAIN FAMILY MEMBER 3-RELATED enzyme activator activity#GO:0008047;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695 G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HUMAN|HGNC=18524|UniProtKB=Q96A47 Q96A47 ISL2 PTHR24204:SF2 INSULIN GENE ENHANCER PROTEIN INSULIN GENE ENHANCER PROTEIN ISL-2 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;cell development#GO:0048468;cell differentiation#GO:0030154;cell projection organization#GO:0030030;regulation of transcription by RNA polymerase II#GO:0006357;cell morphogenesis#GO:0000902;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cell fate commitment#GO:0045165;neuron development#GO:0048666;axonogenesis#GO:0007409;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;neuron projection development#GO:0031175;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;positive regulation of macromolecule metabolic process#GO:0010604;neuron differentiation#GO:0030182;cell fate specification#GO:0001708;plasma membrane bounded cell projection morphogenesis#GO:0120039;positive regulation of transcription by RNA polymerase II#GO:0045944;cell projection morphogenesis#GO:0048858;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;positive regulation of cellular process#GO:0048522;neuron fate commitment#GO:0048663;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;axon development#GO:0061564;regulation of metabolic process#GO:0019222;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;positive regulation of DNA-templated transcription#GO:0045893;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=18559|UniProtKB=Q9H5Q4 Q9H5Q4 TFB2M PTHR11727:SF13 DIMETHYLADENOSINE TRANSFERASE DIMETHYLADENOSINE TRANSFERASE 2, MITOCHONDRIAL rRNA (adenine) methyltransferase activity#GO:0016433;catalytic activity, acting on a rRNA#GO:0140102;N-methyltransferase activity#GO:0008170;transcription regulator activity#GO:0140110;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;RNA methyltransferase activity#GO:0008173;catalytic activity, acting on RNA#GO:0140098;rRNA methyltransferase activity#GO:0008649;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;transferase activity#GO:0016740 rRNA metabolic process#GO:0016072;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;mitochondrial transcription#GO:0006390;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;mitochondrial gene expression#GO:0140053;rRNA processing#GO:0006364;mitochondrial RNA metabolic process#GO:0000959;macromolecule modification#GO:0043412;RNA methylation#GO:0001510;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;cellular component organization or biogenesis#GO:0071840;rRNA methylation#GO:0031167;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;RNA processing#GO:0006396;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;macromolecule methylation#GO:0043414;RNA modification#GO:0009451;ribosome biogenesis#GO:0042254;RNA metabolic process#GO:0016070;methylation#GO:0032259;rRNA modification#GO:0000154;ribonucleoprotein complex biogenesis#GO:0022613;DNA-templated transcription initiation#GO:0006352 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 RNA metabolism protein#PC00031;RNA methyltransferase#PC00033 HUMAN|HGNC=29876|UniProtKB=Q9BWL3 Q9BWL3 LTAP1 PTHR21425:SF2 NICE-3 LIPID TRANSPORT AUXILIARY PROTEIN 1 transport#GO:0006810;phagocytosis#GO:0006909;endocytosis#GO:0006897;import into cell#GO:0098657;establishment of localization#GO:0051234;localization#GO:0051179 HUMAN|HGNC=7529|UniProtKB=P53602 P53602 MVD PTHR10977:SF3 DIPHOSPHOMEVALONATE DECARBOXYLASE DIPHOSPHOMEVALONATE DECARBOXYLASE lyase activity#GO:0016829;carbon-carbon lyase activity#GO:0016830;carboxy-lyase activity#GO:0016831;catalytic activity#GO:0003824 isoprenoid metabolic process#GO:0006720;organophosphate biosynthetic process#GO:0090407;acetyl-CoA metabolic process#GO:0006084;isoprenoid biosynthetic process#GO:0008299;phospholipid biosynthetic process#GO:0008654;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;phospholipid metabolic process#GO:0006644;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;purine-containing compound metabolic process#GO:0072521;acyl-CoA metabolic process#GO:0006637;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;sulfur compound metabolic process#GO:0006790;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 decarboxylase#PC00089;lyase#PC00144 Cholesterol biosynthesis#P00014>Diphosphomevalonate decarboxylase#P00496 HUMAN|HGNC=3126|UniProtKB=Q9UH73 Q9UH73 EBF1 PTHR10747:SF26 TRANSCRIPTION FACTOR COE FAMILY MEMBER TRANSCRIPTION FACTOR COE1 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA-binding transcription factor#PC00218;P53-like transcription factor#PC00253 HUMAN|HGNC=23720|UniProtKB=Q70SY1 Q70SY1 CREB3L2 PTHR46004:SF2 CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN A CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 2 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>CREB#P00713;Transcription regulation by bZIP transcription factor#P00055>CREB#P01383 HUMAN|HGNC=28233|UniProtKB=Q6AI12 Q6AI12 ANKRD40 PTHR24192:SF1 ANKYRIN REPEAT DOMAIN 40 ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 40 HUMAN|HGNC=15846|UniProtKB=Q9NP74 Q9NP74 PALMD PTHR46881:SF1 PALMDELPHIN PALMDELPHIN intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=30262|UniProtKB=Q96C36 Q96C36 PYCR2 PTHR11645:SF61 PYRROLINE-5-CARBOXYLATE REDUCTASE PYRROLINE-5-CARBOXYLATE REDUCTASE 2 oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 small molecule biosynthetic process#GO:0044283;amino acid biosynthetic process#GO:0008652;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;proteinogenic amino acid biosynthetic process#GO:0170038;carboxylic acid biosynthetic process#GO:0046394;cellular process#GO:0009987;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;amino acid metabolic process#GO:0006520;biosynthetic process#GO:0009058;proteinogenic amino acid metabolic process#GO:0170039;small molecule metabolic process#GO:0044281 reductase#PC00198;metabolite interconversion enzyme#PC00262 Proline biosynthesis#P02768>Pyrroline-5-carboxylate reductase#P03113 HUMAN|HGNC=28706|UniProtKB=Q96NU1 Q96NU1 SAMD11 PTHR12247:SF67 POLYCOMB GROUP PROTEIN STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 11 chromatin binding#GO:0003682;histone binding#GO:0042393;binding#GO:0005488;protein binding#GO:0005515 negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219 cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear ubiquitin ligase complex#GO:0000152;intracellular membrane-bounded organelle#GO:0043231;ubiquitin ligase complex#GO:0000151;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;PcG protein complex#GO:0031519;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;PRC1 complex#GO:0035102;transferase complex#GO:1990234 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=12507|UniProtKB=Q9NZI7 Q9NZI7 UBP1 PTHR11037:SF13 TRANSCRIPTION FACTOR CP2 UPSTREAM-BINDING PROTEIN 1 transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription activator activity#GO:0001216;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;sequence-specific DNA binding#GO:0043565 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218 HUMAN|HGNC=13909|UniProtKB=Q9NQL9 Q9NQL9 DMRT3 PTHR12322:SF120 DOUBLESEX AND MAB-3 RELATED TRANSCRIPTION FACTOR DMRT DOUBLESEX- AND MAB-3-RELATED TRANSCRIPTION FACTOR 3 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of biological process#GO:0050789;developmental process involved in reproduction#GO:0003006;reproductive process#GO:0022414;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;sex differentiation#GO:0007548;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;developmental process#GO:0032502;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 DNA-binding transcription factor#PC00218 HUMAN|HGNC=21374|UniProtKB=Q96EU6 Q96EU6 RRP36 PTHR21738:SF0 RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;RNA processing#GO:0006396;maturation of SSU-rRNA#GO:0030490;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;ribosomal small subunit biogenesis#GO:0042274 nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;membraneless organelle#GO:0043228;organelle lumen#GO:0043233;90S preribosome#GO:0030686;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;preribosome#GO:0030684;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=15911|UniProtKB=O00567 O00567 NOP56 PTHR10894:SF0 NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58 NUCLEOLAR PROTEIN 56 RNA binding#GO:0003723;snoRNA binding#GO:0030515;binding#GO:0005488;nucleic acid binding#GO:0003676 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;sno(s)RNA-containing ribonucleoprotein complex#GO:0005732 RNA metabolism protein#PC00031 HUMAN|HGNC=7376|UniProtKB=P21757 P21757 MSR1 PTHR19331:SF440 SCAVENGER RECEPTOR DOMAIN-CONTAINING MACROPHAGE SCAVENGER RECEPTOR TYPES I AND II lipoprotein particle binding#GO:0071813;binding#GO:0005488;low-density lipoprotein particle binding#GO:0030169;peptide binding#GO:0042277;protein-lipid complex binding#GO:0071814;cargo receptor activity#GO:0038024;protein-containing complex binding#GO:0044877 multicellular organismal process#GO:0032501;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of biological process#GO:0050789;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;plasma lipoprotein particle clearance#GO:0034381;regulation of localization#GO:0032879 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 protease#PC00190;serine protease#PC00203 HUMAN|HGNC=12539|UniProtKB=Q9HAW7 Q9HAW7 UGT1A7 PTHR48050:SF6 STEROL 3-BETA-GLUCOSYLTRANSFERASE UDP-GLUCURONOSYLTRANSFERASE 1A10-RELATED glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194;molecular function regulator activity#GO:0098772;transferase activity#GO:0016740;catalytic activity#GO:0003824;enzyme inhibitor activity#GO:0004857;protein binding#GO:0005515;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;binding#GO:0005488;enzyme binding#GO:0019899 response to steroid hormone#GO:0048545;system development#GO:0048731;anatomical structure development#GO:0048856;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;developmental process#GO:0032502;lipid metabolic process#GO:0006629;sterol metabolic process#GO:0016125;pigment metabolic process#GO:0042440;biological regulation#GO:0065007;hormone metabolic process#GO:0042445;multicellular organismal process#GO:0032501;cellular response to chemical stimulus#GO:0070887;animal gross anatomical part developmental process#GO:0160108;regulation of biological quality#GO:0065008;estrogen metabolic process#GO:0008210;regulation of hormone levels#GO:0010817;response to endogenous stimulus#GO:0009719;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;cellular response to hormone stimulus#GO:0032870;liver development#GO:0001889;metabolic process#GO:0008152;multicellular organism development#GO:0007275;cellular response to steroid hormone stimulus#GO:0071383;animal organ development#GO:0048513;cellular process#GO:0009987;response to hormone#GO:0009725;steroid metabolic process#GO:0008202;response to chemical#GO:0042221;response to lipid#GO:0033993;cellular response to lipid#GO:0071396 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111;transferase#PC00220 HUMAN|HGNC=24468|UniProtKB=Q8IUH3 Q8IUH3 RBM45 PTHR24012:SF812 RNA BINDING PROTEIN RNA-BINDING PROTEIN 45 RNA binding#GO:0003723;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 RNA metabolism protein#PC00031 HUMAN|HGNC=27387|UniProtKB=Q6UX98 Q6UX98 ZDHHC24 PTHR22883:SF414 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE ZDHHC24-RELATED transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746;catalytic activity, acting on a protein#GO:0140096;palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 protein targeting#GO:0006605;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of protein localization to membrane#GO:0090150;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;localization within membrane#GO:0051668;protein targeting to membrane#GO:0006612 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226 protein modifying enzyme#PC00260 HUMAN|HGNC=29147|UniProtKB=Q9Y2D9 Q9Y2D9 ZNF652 PTHR24394:SF21 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 652 DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HUMAN|HGNC=2857|UniProtKB=Q13574 Q13574 DGKZ PTHR11255:SF43 DIACYLGLYCEROL KINASE DIACYLGLYCEROL KINASE ZETA transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773;lipid kinase activity#GO:0001727 phospholipid metabolic process#GO:0006644;signaling#GO:0023052;phospholipid biosynthetic process#GO:0008654;regulation of cellular process#GO:0050794;glycerolipid metabolic process#GO:0046486;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;intracellular signal transduction#GO:0035556;organophosphate biosynthetic process#GO:0090407;cell communication#GO:0007154;biological regulation#GO:0065007;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;glycerophospholipid metabolic process#GO:0006650;glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987;signal transduction#GO:0007165;organophosphate metabolic process#GO:0019637;neutral lipid metabolic process#GO:0006638;lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474;acylglycerol metabolic process#GO:0006639;metabolic process#GO:0008152 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;synapse#GO:0045202;glutamatergic synapse#GO:0098978;cell junction#GO:0030054 kinase#PC00137;metabolite interconversion enzyme#PC00262 Gonadotropin-releasing hormone receptor pathway#P06664>DGK-zeta#P06790 HUMAN|HGNC=17133|UniProtKB=Q13342 Q13342 SP140 PTHR46386:SF8 NUCLEAR BODY PROTEIN SP140 NUCLEAR BODY PROTEIN SP140 DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=18738|UniProtKB=O94844 O94844 RHOBTB1 PTHR24072:SF120 RHO FAMILY GTPASE RHO-RELATED BTB DOMAIN-CONTAINING PROTEIN 1 small molecule binding#GO:0036094;anion binding#GO:0043168;ion binding#GO:0043167;GTPase activity#GO:0003924;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleotide binding#GO:0000166;guanyl nucleotide binding#GO:0019001;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;binding#GO:0005488;kinase binding#GO:0019900;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;nucleoside phosphate binding#GO:1901265;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;protein binding#GO:0005515;ribonucleotide binding#GO:0032553;hydrolase activity, acting on acid anhydrides#GO:0016817;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;carbohydrate derivative binding#GO:0097367;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363 biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;regulation of actin cytoskeleton organization#GO:0032956;signal transduction#GO:0007165;cellular process#GO:0009987;organelle organization#GO:0006996;actin filament organization#GO:0007015;cellular component organization or biogenesis#GO:0071840;regulation of anatomical structure morphogenesis#GO:0022603;regulation of actin filament-based process#GO:0032970;signaling#GO:0023052;regulation of developmental process#GO:0050793;regulation of cytoskeleton organization#GO:0051493;response to stimulus#GO:0050896;regulation of cellular component organization#GO:0051128;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of cell shape#GO:0008360;cellular response to stimulus#GO:0051716;regulation of organelle organization#GO:0033043;cellular component organization#GO:0016043;supramolecular fiber organization#GO:0097435;regulation of biological quality#GO:0065008;cell communication#GO:0007154;actin filament-based process#GO:0030029;establishment or maintenance of cell polarity#GO:0007163;cortical cytoskeleton organization#GO:0030865 membrane#GO:0016020;cell periphery#GO:0071944;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;cytoplasm#GO:0005737;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622 G-protein#PC00020;small GTPase#PC00208 HUMAN|HGNC=28332|UniProtKB=Q8WUD4 Q8WUD4 CCDC12 PTHR31551:SF1 PRE-MRNA-SPLICING FACTOR CWF18 COILED-COIL DOMAIN-CONTAINING PROTEIN 12 nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;U2-type spliceosomal complex#GO:0005684;intracellular membrane-bounded organelle#GO:0043231;post-mRNA release spliceosomal complex#GO:0071014;spliceosomal complex#GO:0005681;nucleus#GO:0005634 RNA splicing factor#PC00148;RNA processing factor#PC00147 HUMAN|HGNC=30038|UniProtKB=Q86XP0 Q86XP0 PLA2G4D PTHR10728:SF31 CYTOSOLIC PHOSPHOLIPASE A2 CYTOSOLIC PHOSPHOLIPASE A2 DELTA lipid binding#GO:0008289;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;binding#GO:0005488;A2-type glycerophospholipase activity#GO:0004623;phospholipase activity#GO:0120569;glycerophospholipase activity#GO:0004620;cation binding#GO:0043169;hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689;ion binding#GO:0043167;lipase activity#GO:0016298;small molecule binding#GO:0036094;hydrolase activity, acting on ester bonds#GO:0016788;phospholipid binding#GO:0005543;catalytic activity#GO:0003824 glycerophospholipid catabolic process#GO:0046475;organophosphate catabolic process#GO:0046434;lipid metabolic process#GO:0006629;glycerolipid catabolic process#GO:0046503;metabolic process#GO:0008152;phospholipid metabolic process#GO:0006644;catabolic process#GO:0009056;phospholipid catabolic process#GO:0009395;glycerophospholipid metabolic process#GO:0006650;glycerolipid metabolic process#GO:0046486;cellular process#GO:0009987;lipid catabolic process#GO:0016042;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;organophosphate metabolic process#GO:0019637 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 phospholipase#PC00186 Angiogenesis#P00005>cPLA2#P00251 HUMAN|HGNC=3419|UniProtKB=P42566 P42566 EPS15 PTHR11216:SF54 EH DOMAIN EPIDERMAL GROWTH FACTOR RECEPTOR SUBSTRATE 15 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 cellular process#GO:0009987;establishment of localization in cell#GO:0051649;endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;transport#GO:0006810;intracellular transport#GO:0046907;endosomal transport#GO:0016197;cellular localization#GO:0051641;import into cell#GO:0098657;establishment of localization#GO:0051234;localization#GO:0051179 intracellular anatomical structure#GO:0005622;coated membrane#GO:0048475;membrane coat#GO:0030117;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;clathrin-coated pit#GO:0005905;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;clathrin coat#GO:0030118;endomembrane system#GO:0012505 membrane traffic protein#PC00150 HUMAN|HGNC=25612|UniProtKB=Q8IZM8 Q8IZM8 ZNF654 PTHR15507:SF16 ZINC FINGER PROTEIN RLF ZINC FINGER PROTEIN 654 transcription regulator activity#GO:0140110;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=2375|UniProtKB=Q9NVC6 Q9NVC6 MED17 PTHR13114:SF7 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17 transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;mediator complex#GO:0016592;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;RNA polymerase II transcription regulator complex#GO:0090575;core mediator complex#GO:0070847;nucleus#GO:0005634 general transcription factor#PC00259;RNA metabolism protein#PC00031 HUMAN|HGNC=17302|UniProtKB=Q7Z3B1 Q7Z3B1 NEGR1 PTHR42757:SF6 IGLON FAMILY OF IMMUNOGLOBULIN SUPERFAMILY-RELATED NEURONAL GROWTH REGULATOR 1 regulation of synapse structure or activity#GO:0050803;regulation of biological quality#GO:0065008;cell adhesion#GO:0007155;regulation of cell junction assembly#GO:1901888;regulation of synapse organization#GO:0050807;regulation of synapse assembly#GO:0051963;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of cellular component biogenesis#GO:0044087;cell-cell adhesion#GO:0098609;regulation of biological process#GO:0050789;heterophilic cell-cell adhesion#GO:0007157;cellular process#GO:0009987 cell junction#GO:0030054;postsynaptic density#GO:0014069;cellular anatomical structure#GO:0110165;synapse#GO:0045202;neuron to neuron synapse#GO:0098984;postsynaptic specialization#GO:0099572;asymmetric synapse#GO:0032279;organelle#GO:0043226;plasma membrane#GO:0005886;postsynapse#GO:0098794;membrane#GO:0016020;cell periphery#GO:0071944 immunoglobulin#PC00123 HUMAN|HGNC=17970|UniProtKB=Q9BPZ3 Q9BPZ3 PAIP2 PTHR13154:SF2 POLYADENYLATE-BINDING PROTEIN-INTERACTING PROTEIN 2 POLYADENYLATE-BINDING PROTEIN-INTERACTING PROTEIN 2 translation regulator activity#GO:0045182 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of translation#GO:0006417;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of translation#GO:0017148;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=2201|UniProtKB=P02461 P02461 COL3A1 PTHR24023:SF604 COLLAGEN ALPHA COLLAGEN ALPHA-1(III) CHAIN extracellular matrix structural constituent#GO:0005201;structural molecule activity#GO:0005198 anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;animal organ morphogenesis#GO:0009887;animal gross anatomical part developmental process#GO:0160108;extracellular structure organization#GO:0043062;system development#GO:0048731;external encapsulating structure organization#GO:0045229;skeletal system development#GO:0001501;extracellular matrix organization#GO:0030198;anatomical structure development#GO:0048856;cellular process#GO:0009987;skeletal system morphogenesis#GO:0048705;skin development#GO:0043588;multicellular organismal process#GO:0032501;developmental process#GO:0032502;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;animal organ development#GO:0048513 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;interstitial matrix#GO:0005614;supramolecular complex#GO:0099080;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576;extracellular protein-containing complex#GO:0140392 extracellular matrix structural protein#PC00103;extracellular matrix protein#PC00102 Integrin signalling pathway#P00034>Collagen#P00922 HUMAN|HGNC=6243|UniProtKB=Q9Y6H6 Q9Y6H6 KCNE3 PTHR15282:SF6 POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY E MEMBER 1, 3 POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY E MEMBER 3 transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;ion channel regulator activity#GO:0099106;molecular function regulator activity#GO:0098772;monoatomic cation channel activity#GO:0005261;potassium channel activity#GO:0005267;transporter regulator activity#GO:0141108;transmembrane transporter binding#GO:0044325;channel activity#GO:0015267;channel regulator activity#GO:0016247;potassium ion transmembrane transporter activity#GO:0015079;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;potassium channel regulator activity#GO:0015459;binding#GO:0005488;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;protein binding#GO:0005515 actin-mediated cell contraction#GO:0070252;regulation of heart contraction#GO:0008016;striated muscle contraction#GO:0006941;metal ion transport#GO:0030001;circulatory system process#GO:0003013;actin filament-based process#GO:0030029;cardiac muscle contraction#GO:0060048;localization#GO:0051179;monoatomic cation transport#GO:0006812;actin filament-based movement#GO:0030048;multicellular organismal process#GO:0032501;potassium ion transport#GO:0006813;blood circulation#GO:0008015;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;regulation of system process#GO:0044057;transport#GO:0006810;muscle contraction#GO:0006936;establishment of localization#GO:0051234;cardiac muscle cell contraction#GO:0086003;heart contraction#GO:0060047;system process#GO:0003008;heart process#GO:0003015;regulation of biological process#GO:0050789;muscle system process#GO:0003012;action potential#GO:0001508;export from cell#GO:0140352;transmembrane transport#GO:0055085;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;cardiac muscle cell action potential involved in contraction#GO:0086002;regulation of multicellular organismal process#GO:0051239;monoatomic cation transmembrane transport#GO:0098655;regulation of membrane potential#GO:0042391 transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797 voltage-gated ion channel#PC00241 HUMAN|HGNC=12811|UniProtKB=P51811 P51811 XK PTHR14297:SF8 MEMBRANE TRANSPORT PROTEIN XK FAMILY MEMBER ENDOPLASMIC RETICULUM MEMBRANE ADAPTER PROTEIN XK protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020 HUMAN|HGNC=696|UniProtKB=Q9Y689 Q9Y689 ARL5A PTHR11711:SF147 ADP RIBOSYLATION FACTOR-RELATED ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 5A nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;binding#GO:0005488;guanyl nucleotide binding#GO:0019001;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;ribonucleotide binding#GO:0032553;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;nucleotide binding#GO:0000166 protein localization to membrane#GO:0072657;protein localization to organelle#GO:0033365;localization within membrane#GO:0051668;cellular localization#GO:0051641;localization#GO:0051179;protein transport#GO:0015031;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;protein localization to Golgi apparatus#GO:0034067;transport#GO:0006810;intracellular protein transport#GO:0006886;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104 membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;Golgi apparatus subcompartment#GO:0098791 G-protein#PC00020 HUMAN|HGNC=26302|UniProtKB=Q17RB8 Q17RB8 LONRF1 PTHR23327:SF4 RING FINGER PROTEIN 127 LON PEPTIDASE N-TERMINAL DOMAIN AND RING FINGER PROTEIN 1 ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=10740|UniProtKB=Q9H3T2 Q9H3T2 SEMA6C PTHR11036:SF11 SEMAPHORIN SEMAPHORIN-6C signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;signaling receptor binding#GO:0005102;binding#GO:0005488;molecular function activator activity#GO:0140677;protein binding#GO:0005515 regulation of cell motility#GO:2000145;cell communication#GO:0007154;anatomical structure development#GO:0048856;system development#GO:0048731;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;cellular developmental process#GO:0048869;neuron projection guidance#GO:0097485;positive regulation of locomotion#GO:0040017;neurogenesis#GO:0022008;regulation of cell migration#GO:0030334;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;plasma membrane bounded cell projection organization#GO:0120036;axon guidance#GO:0007411;axon development#GO:0061564;positive regulation of cellular process#GO:0048522;positive regulation of cell migration#GO:0030335;axonogenesis#GO:0007409;neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;cell differentiation#GO:0030154;cell projection organization#GO:0030030;response to stimulus#GO:0050896;cell morphogenesis#GO:0000902;signaling#GO:0023052;cell development#GO:0048468;positive regulation of cell motility#GO:2000147;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cell projection morphogenesis#GO:0048858;neuron differentiation#GO:0030182;cell surface receptor signaling pathway#GO:0007166;plasma membrane bounded cell projection morphogenesis#GO:0120039;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;neuron projection development#GO:0031175;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 membrane-bound signaling molecule#PC00152 HUMAN|HGNC=17856|UniProtKB=Q9UJ83 Q9UJ83 HACL1 PTHR43710:SF2 2-HYDROXYACYL-COA LYASE 2-HYDROXYACYL-COA LYASE 1 ion binding#GO:0043167;anion binding#GO:0043168;binding#GO:0005488;small molecule binding#GO:0036094;heterocyclic compound binding#GO:1901363;cation binding#GO:0043169 monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;small molecule catabolic process#GO:0044282;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;oxoacid metabolic process#GO:0043436;fatty acid catabolic process#GO:0009062;lipid oxidation#GO:0034440;lipid catabolic process#GO:0016042;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;monocarboxylic acid catabolic process#GO:0072329;fatty acid oxidation#GO:0019395;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;lipid modification#GO:0030258 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microbody#GO:0042579;peroxisome#GO:0005777 metabolite interconversion enzyme#PC00262;lyase#PC00144 HUMAN|HGNC=33782|UniProtKB=Q6GMV3 Q6GMV3 PTRHD1 PTHR46194:SF1 PEPTIDYL-TRNA HYDROLASE PTRHD1-RELATED PEPTIDYL-TRNA HYDROLASE PTRHD1-RELATED HUMAN|HGNC=29415|UniProtKB=Q8TF50 Q8TF50 ZNF526 PTHR24377:SF770 IP01015P-RELATED ZINC FINGER PROTEIN 526 RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=7049|UniProtKB=Q09328 Q09328 MGAT5 PTHR15075:SF5 ALPHA-MANNOSIDE BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE ALPHA-1,6-MANNOSYLGLYCOPROTEIN 6-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE A catalytic activity, acting on a protein#GO:0140096;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;acetylglucosaminyltransferase activity#GO:0008375;transferase activity#GO:0016740;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487;biosynthetic process#GO:0009058 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226 metabolite interconversion enzyme#PC00262;glycosyltransferase#PC00111;transferase#PC00220 HUMAN|HGNC=19237|UniProtKB=Q9NR45 Q9NR45 NANS PTHR42966:SF1 N-ACETYLNEURAMINATE SYNTHASE N-ACETYLNEURAMINATE-9-PHOSPHATE SYNTHASE transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;catalytic activity#GO:0003824;transferase activity#GO:0016740 acetyltransferase#PC00038;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=6438|UniProtKB=Q9C075 Q9C075 KRT23 PTHR23239:SF44 INTERMEDIATE FILAMENT KERATIN, TYPE I CYTOSKELETAL 23 structural molecule activity#GO:0005198 intermediate filament-based process#GO:0045103;animal gross anatomical part developmental process#GO:0160108;intermediate filament organization#GO:0045109;tissue morphogenesis#GO:0048729;anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;intermediate filament cytoskeleton organization#GO:0045104;cell differentiation#GO:0030154;developmental process#GO:0032502;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;morphogenesis of an epithelium#GO:0002009;organelle organization#GO:0006996;cellular process#GO:0009987;epithelium development#GO:0060429;epithelial cell differentiation#GO:0030855;tissue development#GO:0009888;cytoskeleton organization#GO:0007010 intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;supramolecular complex#GO:0099080;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intermediate filament#GO:0005882;supramolecular fiber#GO:0099512;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 intermediate filament#PC00129 HUMAN|HGNC=14988|UniProtKB=Q9H488 Q9H488 POFUT1 PTHR21420:SF3 GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 1 GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 1 protein modifying enzyme#PC00260 Notch signaling pathway#P00045>Neurotic#P01115 HUMAN|HGNC=9645|UniProtKB=Q05209 Q05209 PTPN12 PTHR45983:SF3 TYROSINE PHOSPHATSE N18, PUTATIVE-RELATED TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 12 hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;protein tyrosine phosphatase activity#GO:0004725;hydrolase activity#GO:0016787 regulation of biological process#GO:0050789;regulation of ERBB signaling pathway#GO:1901184;regulation of cell communication#GO:0010646;regulation of epidermal growth factor receptor signaling pathway#GO:0042058;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cellular process#GO:0050794;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 Integrin signalling pathway#P00034>PTP-PEST#P00915 HUMAN|HGNC=24804|UniProtKB=Q6ZNE9 Q6ZNE9 RUFY4 PTHR47732:SF1 RUN AND FYVE DOMAIN-CONTAINING PROTEIN 4 RUN AND FYVE DOMAIN-CONTAINING PROTEIN 4 HUMAN|HGNC=17293|UniProtKB=Q9BZL6 Q9BZL6 PRKD2 PTHR22968:SF12 PROTEIN KINASE C, MU SERINE_THREONINE-PROTEIN KINASE D2 protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824 G protein-coupled receptor signaling pathway#GO:0007186;phospholipase C-activating G protein-coupled receptor signaling pathway#GO:0007200;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 VEGF signaling pathway#P00056>PKC#P01425;Angiogenesis#P00005>PKC#P00219;EGF receptor signaling pathway#P00018>PKC#P00565;CCKR signaling map#P06959>PRKD2#P07216 HUMAN|HGNC=20693|UniProtKB=P58417 P58417 NXPH1 PTHR17103:SF13 NEUREXOPHILIN NEUREXOPHILIN-1 protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488 regulation of cell communication#GO:0010646;biological regulation#GO:0065007;modulation of chemical synaptic transmission#GO:0050804;regulation of cellular process#GO:0050794;regulation of trans-synaptic signaling#GO:0099177;regulation of signaling#GO:0023051;regulation of biological process#GO:0050789 synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell junction#GO:0030054;GABA-ergic synapse#GO:0098982 intercellular signal molecule#PC00207 HUMAN|HGNC=23212|UniProtKB=Q7Z406 Q7Z406 MYH14 PTHR45615:SF31 MYOSIN HEAVY CHAIN, NON-MUSCLE MYOSIN-14 catalytic activity#GO:0003824;microfilament motor activity#GO:0000146;macromolecular conformation isomerase activity#GO:0120543;cytoskeletal protein binding#GO:0008092;cytoskeletal motor activity#GO:0003774;isomerase activity#GO:0016853;polypeptide conformation or assembly isomerase activity#GO:0120544;binding#GO:0005488;ATP-dependent activity#GO:0140657;actin binding#GO:0003779;actin filament binding#GO:0051015;protein binding#GO:0005515;protein-containing complex binding#GO:0044877 mitotic cell cycle#GO:0000278;actin cytoskeleton organization#GO:0030036;mitotic cytokinesis#GO:0000281;actomyosin structure organization#GO:0031032;regulation of developmental process#GO:0050793;cell cycle#GO:0007049;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;cell cycle process#GO:0022402;cell division#GO:0051301;regulation of cell shape#GO:0008360;cytoskeleton-dependent cytokinesis#GO:0061640;regulation of biological quality#GO:0065008;cytokinesis#GO:0000910;actin filament-based process#GO:0030029;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;organelle organization#GO:0006996;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;regulation of anatomical structure morphogenesis#GO:0022603;mitotic cell cycle process#GO:1903047 supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;supramolecular complex#GO:0099080;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;myosin complex#GO:0016459;actin cytoskeleton#GO:0015629;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 actin or actin-binding cytoskeletal protein#PC00041 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Myosin#P00867;Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097;Cytoskeletal regulation by Rho GTPase#P00016>Myosin#P00522 HUMAN|HGNC=24054|UniProtKB=Q8NG31 Q8NG31 KNL1 PTHR16520:SF3 KINETOCHORE SCAFFOLD 1 OUTER KINETOCHORE KNL1 COMPLEX SUBUNIT KNL1 cellular process#GO:0009987;cell cycle process#GO:0022402;cell cycle#GO:0007049;macromolecule localization#GO:0033036;attachment of spindle microtubules to kinetochore#GO:0008608;nuclear chromosome segregation#GO:0098813;protein localization to kinetochore#GO:0034501;chromosome localization#GO:0050000;protein localization to organelle#GO:0033365;chromosome segregation#GO:0007059;metaphase chromosome alignment#GO:0051310;organelle localization#GO:0051640;intracellular protein localization#GO:0008104;localization#GO:0051179 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=9236|UniProtKB=P37231 P37231 PPARG PTHR24082:SF488 NUCLEAR HORMONE RECEPTOR PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA molecular transducer activity#GO:0060089;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;nuclear receptor activity#GO:0004879;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription repressor activity#GO:0001217;transcription regulatory region nucleic acid binding#GO:0001067;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023 negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;cellular response to stimulus#GO:0051716;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of lipid metabolic process#GO:0019216;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;cell communication#GO:0007154;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;response to hormone#GO:0009725;positive regulation of macromolecule metabolic process#GO:0010604;response to chemical#GO:0042221;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;negative regulation of biological process#GO:0048519;signaling#GO:0023052;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;cellular response to hormone stimulus#GO:0032870;cellular response to chemical stimulus#GO:0070887;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;hormone-mediated signaling pathway#GO:0009755;negative regulation of DNA-templated transcription#GO:0045892 nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513 C4 zinc finger nuclear receptor#PC00169 CCKR signaling map#P06959>PPARgamma#P07060;Gonadotropin-releasing hormone receptor pathway#P06664>PPARalpha/gamma#P06744;Gonadotropin-releasing hormone receptor pathway#P06664>PPARgamma#P06721 HUMAN|HGNC=25439|UniProtKB=Q6ICL3 Q6ICL3 TANGO2 PTHR17985:SF28 SER/THR-RICH PROTEIN T10 IN DGCR REGION TRANSPORT AND GOLGI ORGANIZATION PROTEIN 2 HOMOLOG protein localization to extracellular region#GO:0071692;Golgi organization#GO:0007030;cellular component organization#GO:0016043;export from cell#GO:0140352;protein transport#GO:0015031;secretion by cell#GO:0032940;secretion#GO:0046903;protein secretion#GO:0009306;localization#GO:0051179;cellular process#GO:0009987;establishment of protein localization#GO:0045184;organelle organization#GO:0006996;macromolecule localization#GO:0033036;endomembrane system organization#GO:0010256;transport#GO:0006810;establishment of protein localization to extracellular region#GO:0035592;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794 HUMAN|HGNC=52277|UniProtKB=A0A0J9YWL9 A0A0J9YWL9 TEX13C PTHR23111:SF105 ZINC FINGER PROTEIN TESTIS-EXPRESSED PROTEIN 13C RNA binding#GO:0003723;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488 HUMAN|HGNC=1069|UniProtKB=P12643 P12643 BMP2 PTHR11848:SF143 TGF-BETA FAMILY BONE MORPHOGENETIC PROTEIN 2 cytokine activity#GO:0005125;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772 animal organ development#GO:0048513;multicellular organism development#GO:0007275;cell surface receptor signaling pathway#GO:0007166;cellular response to BMP stimulus#GO:0071773;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;heart development#GO:0007507;cellular process#GO:0009987;signal transduction#GO:0007165;cellular response to growth factor stimulus#GO:0071363;animal gross anatomical part developmental process#GO:0160108;osteoblast differentiation#GO:0001649;cellular response to endogenous stimulus#GO:0071495;circulatory system development#GO:0072359;cell differentiation#GO:0030154;response to stimulus#GO:0050896;signaling#GO:0023052;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;cellular developmental process#GO:0048869;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;response to BMP#GO:0071772;developmental process#GO:0032502;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;system development#GO:0048731;ossification#GO:0001503;animal organ morphogenesis#GO:0009887;regulation of cellular process#GO:0050794;response to growth factor#GO:0070848;BMP signaling pathway#GO:0030509;cellular response to stimulus#GO:0051716;heart morphogenesis#GO:0003007 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 growth factor#PC00112 TGF-beta signaling pathway#P00052>TGFbeta#P01286;Gonadotropin-releasing hormone receptor pathway#P06664>BMP2/4/15#P06817 HUMAN|HGNC=13900|UniProtKB=Q9HBY8 Q9HBY8 SGK2 PTHR24356:SF197 SERINE/THREONINE-PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE SGK2 molecular function regulator activity#GO:0098772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;ion channel regulator activity#GO:0099106;transferase activity#GO:0016740;catalytic activity#GO:0003824;channel regulator activity#GO:0016247;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;potassium channel regulator activity#GO:0015459;transporter regulator activity#GO:0141108;protein serine/threonine kinase activity#GO:0004674 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=32213|UniProtKB=Q5T7M9 Q5T7M9 DIPK1A PTHR21093:SF4 DIVERGENT PROTEIN KINASE DOMAIN 1C-RELATED DIVERGENT PROTEIN KINASE DOMAIN 1A HUMAN|HGNC=1359|UniProtKB=Q9NQ60 Q9NQ60 EQTN PTHR36874:SF1 EQUATORIN EQUATORIN fusion of sperm to egg plasma membrane involved in single fertilization#GO:0007342;cellular process#GO:0009987;single fertilization#GO:0007338;vesicle-mediated transport#GO:0016192;acrosomal vesicle exocytosis#GO:0060478;transport#GO:0006810;regulated exocytosis#GO:0045055;calcium-ion regulated exocytosis#GO:0017156;exocytosis#GO:0006887;establishment of localization#GO:0051234;import into cell#GO:0098657;acrosome reaction#GO:0007340;export from cell#GO:0140352;cellular process involved in reproduction in multicellular organism#GO:0022412;reproductive process#GO:0022414;fertilization#GO:0009566;endocytosis#GO:0006897;sexual reproduction#GO:0019953;secretion by cell#GO:0032940;multicellular organismal reproductive process#GO:0048609;localization#GO:0051179;secretion#GO:0046903 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;secretory granule membrane#GO:0030667;intracellular vesicle#GO:0097708;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;intracellular organelle#GO:0043229;acrosomal vesicle#GO:0001669;cytoplasm#GO:0005737;plasma membrane#GO:0005886;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;cell periphery#GO:0071944;secretory vesicle#GO:0099503;membrane#GO:0016020;vesicle membrane#GO:0012506;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;acrosomal membrane#GO:0002080 HUMAN|HGNC=3299|UniProtKB=P55010 P55010 EIF5 PTHR23001:SF22 EUKARYOTIC TRANSLATION INITIATION FACTOR EUKARYOTIC TRANSLATION INITIATION FACTOR 5 protein binding#GO:0005515;enzyme regulator activity#GO:0030234;binding#GO:0005488;molecular function regulator activity#GO:0098772;translation initiation factor activity#GO:0003743;translation initiation factor binding#GO:0031369;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;translation factor activity#GO:0180051 metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;protein-RNA complex organization#GO:0071826;protein-containing complex organization#GO:0043933;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component assembly#GO:0022607;gene expression#GO:0010467;biosynthetic process#GO:0009058;cytoplasmic translational initiation#GO:0002183;translational initiation#GO:0006413;translation#GO:0006412;protein metabolic process#GO:0019538;protein-RNA complex assembly#GO:0022618;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;protein-containing complex assembly#GO:0065003;cytoplasmic translation#GO:0002181;protein biosynthetic process#GO:0160307;ribonucleoprotein complex biogenesis#GO:0022613 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 HUMAN|HGNC=6665|UniProtKB=Q08397 Q08397 LOXL1 PTHR45817:SF8 LYSYL OXIDASE-LIKE-RELATED LYSYL OXIDASE HOMOLOG 1 catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491 cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;collagen fibril organization#GO:0030199;external encapsulating structure organization#GO:0045229;extracellular structure organization#GO:0043062;cellular component organization#GO:0016043;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576 oxidase#PC00175;oxidoreductase#PC00176 HUMAN|HGNC=30098|UniProtKB=Q8N684 Q8N684 CPSF7 PTHR23204:SF2 CLEAVAGE AND POLYADENYLATION SPECIFIC FACTOR CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 7 binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723 mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;mRNA 3'-end processing#GO:0031124 mRNA cleavage and polyadenylation specificity factor complex#GO:0005847;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;mRNA cleavage factor complex#GO:0005849;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HUMAN|HGNC=21303|UniProtKB=Q8NDY3 Q8NDY3 ADPRHL1 PTHR16222:SF23 ADP-RIBOSYLGLYCOHYDROLASE INACTIVE ADP-RIBOSYLTRANSFERASE ARH2 hydrolase activity#GO:0016787;catalytic activity#GO:0003824 hydrolase#PC00121 HUMAN|HGNC=975|UniProtKB=O75934 O75934 BCAS2 PTHR13296:SF4 BCAS2 PROTEIN PRE-MRNA-SPLICING FACTOR SPF27 RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;mRNA cis splicing, via spliceosome#GO:0045292 nucleus#GO:0005634;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;Prp19 complex#GO:0000974;membrane-bounded organelle#GO:0043227;catalytic step 2 spliceosome#GO:0071013;nuclear protein-containing complex#GO:0140513 RNA splicing factor#PC00148 HUMAN|HGNC=23196|UniProtKB=Q8TAG9 Q8TAG9 EXOC6 PTHR12702:SF2 SEC15 EXOCYST COMPLEX COMPONENT 6 vesicle-mediated transport#GO:0016192;export from cell#GO:0140352;cellular process#GO:0009987;secretion#GO:0046903;establishment of localization#GO:0051234;localization#GO:0051179;exocytosis#GO:0006887;secretion by cell#GO:0032940;transport#GO:0006810 cytoplasm#GO:0005737;exocyst#GO:0000145;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;cell cortex#GO:0005938;intracellular anatomical structure#GO:0005622;vesicle tethering complex#GO:0099023 membrane traffic protein#PC00150 HUMAN|HGNC=9795|UniProtKB=Q92696 Q92696 RABGGTA PTHR11129:SF2 PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT ALPHA catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;prenyltransferase activity#GO:0004659;catalytic activity, acting on a protein#GO:0140096 establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;intracellular transport#GO:0046907;transport#GO:0006810;Golgi vesicle transport#GO:0048193;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;transferase complex#GO:1990234 transferase#PC00220;acyltransferase#PC00042 HUMAN|HGNC=27229|UniProtKB=Q86W74 Q86W74 ANKRD46 PTHR24166:SF28 ROLLING PEBBLES, ISOFORM B ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 46 scaffold/adaptor protein#PC00226 HUMAN|HGNC=3155|UniProtKB=Q9H8V3 Q9H8V3 ECT2 PTHR16777:SF2 PROTEIN ECT2 PROTEIN ECT2 guanyl-nucleotide exchange factor activity#GO:0005085;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function regulator activity#GO:0098772 cytoskeleton-dependent cytokinesis#GO:0061640;mitotic cell cycle process#GO:1903047;cytokinesis#GO:0000910;mitotic cytokinesis#GO:0000281;mitotic cell cycle#GO:0000278;cell cycle#GO:0007049;cell division#GO:0051301;cellular process#GO:0009987;cell cycle process#GO:0022402 cell periphery#GO:0071944;nucleus#GO:0005634;cell cortex#GO:0005938;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 guanyl-nucleotide exchange factor#PC00113;protein-binding activity modulator#PC00095;G-protein modulator#PC00022 HUMAN|HGNC=16156|UniProtKB=Q9BR09 Q9BR09 NEURL2 PTHR12429:SF8 NEURALIZED NEURALIZED-LIKE PROTEIN 2 acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;anatomical structure formation involved in morphogenesis#GO:0048646;striated muscle cell differentiation#GO:0051146;cellular anatomical entity morphogenesis#GO:0032989;developmental process#GO:0032502;actin cytoskeleton organization#GO:0030036;muscle structure development#GO:0061061;cell differentiation#GO:0030154;cell development#GO:0048468;actomyosin structure organization#GO:0031032;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;muscle cell development#GO:0055001;muscle cell differentiation#GO:0042692;anatomical structure morphogenesis#GO:0009653;myofibril assembly#GO:0030239;anatomical structure development#GO:0048856;striated muscle cell development#GO:0055002;supramolecular fiber organization#GO:0097435;animal gross anatomical part developmental process#GO:0160108;cellular component assembly involved in morphogenesis#GO:0010927;organelle assembly#GO:0070925;actin filament-based process#GO:0030029 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 Notch signaling pathway#P00045>Neuralized#P01117 HUMAN|HGNC=25751|UniProtKB=Q7Z392 Q7Z392 TRAPPC11 PTHR14374:SF0 FOIE GRAS TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 11 HUMAN|HGNC=221|UniProtKB=Q9UNA0 Q9UNA0 ADAMTS5 PTHR13723:SF37 ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 5 hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metalloendopeptidase activity#GO:0004222;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 proteolysis#GO:0006508;metabolic process#GO:0008152;extracellular structure organization#GO:0043062;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;protein metabolic process#GO:0019538;extracellular matrix organization#GO:0030198;external encapsulating structure organization#GO:0045229;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;cellular process#GO:0009987 external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 HUMAN|HGNC=24290|UniProtKB=Q8TDX6 Q8TDX6 CSGALNACT1 PTHR12369:SF19 CHONDROITIN SYNTHASE CHONDROITIN SULFATE N-ACETYLGALACTOSAMINYLTRANSFERASE 1 glycosyltransferase activity#GO:0016757;acetylgalactosaminyltransferase activity#GO:0008376;UDP-glycosyltransferase activity#GO:0008194;hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;catalytic activity#GO:0003824 protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;proteoglycan metabolic process#GO:0006029;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein O-linked glycosylation#GO:0006493;chondroitin sulfate proteoglycan metabolic process#GO:0050654;glycoprotein biosynthetic process#GO:0009101;biosynthetic process#GO:0009058;proteoglycan biosynthetic process#GO:0030166;chondroitin sulfate proteoglycan biosynthetic process#GO:0050650 glycosyltransferase#PC00111 HUMAN|HGNC=21584|UniProtKB=Q5M9Q1 Q5M9Q1 NKAPL PTHR13087:SF3 NF-KAPPA B ACTIVATING PROTEIN NKAP-LIKE PROTEIN regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=292|UniProtKB=P30520 P30520 ADSS2 PTHR11846:SF13 ADENYLOSUCCINATE SYNTHETASE ADENYLOSUCCINATE SYNTHETASE ISOZYME 2 catalytic activity#GO:0003824;ligase activity#GO:0016874;ligase activity, forming carbon-nitrogen bonds#GO:0016879 nucleoside phosphate biosynthetic process#GO:1901293;carbohydrate derivative metabolic process#GO:1901135;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;organophosphate biosynthetic process#GO:0090407;primary metabolic process#GO:0044238;nucleoside monophosphate metabolic process#GO:0009123;nucleoside phosphate metabolic process#GO:0006753;IMP metabolic process#GO:0046040;metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing compound biosynthetic process#GO:0034654;nucleobase-containing small molecule metabolic process#GO:0055086;purine nucleoside monophosphate metabolic process#GO:0009126;carbohydrate derivative biosynthetic process#GO:1901137;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;ribose phosphate biosynthetic process#GO:0046390;purine nucleotide biosynthetic process#GO:0006164;nucleoside monophosphate biosynthetic process#GO:0009124;purine-containing compound biosynthetic process#GO:0072522;ribonucleotide metabolic process#GO:0009259;nucleotide biosynthetic process#GO:0009165;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;phosphorus metabolic process#GO:0006793;purine ribonucleoside monophosphate metabolic process#GO:0009167;small molecule metabolic process#GO:0044281 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 ligase#PC00142;metabolite interconversion enzyme#PC00262 Wnt signaling pathway#P00057>NFAT Target Genes#G01559;De novo purine biosynthesis#P02738>Adenylosuccinate synthase#P02890 HUMAN|HGNC=13726|UniProtKB=Q8NEZ4 Q8NEZ4 KMT2C PTHR45888:SF1 HL01030P-RELATED HISTONE-LYSINE N-METHYLTRANSFERASE 2C methyltransferase activity#GO:0008168;protein-lysine N-methyltransferase activity#GO:0016279;transcription regulator activity#GO:0140110;histone methyltransferase activity#GO:0042054;lysine N-methyltransferase activity#GO:0016278;histone modifying activity#GO:0140993;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741;transcription coactivator activity#GO:0003713;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;N-methyltransferase activity#GO:0008170;histone H3K4 methyltransferase activity#GO:0042800;histone H3 methyltransferase activity#GO:0140938;catalytic activity#GO:0003824;transcription coregulator activity#GO:0003712;protein methyltransferase activity#GO:0008276;catalytic activity, acting on a protein#GO:0140096 positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of DNA-templated transcription#GO:0006355 transferase complex#GO:1990234;histone methyltransferase complex#GO:0035097;nuclear protein-containing complex#GO:0140513;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;nucleoplasm#GO:0005654;methyltransferase complex#GO:0034708;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=9887|UniProtKB=Q09028 Q09028 RBBP4 PTHR22850:SF90 WD40 REPEAT FAMILY HISTONE-BINDING PROTEIN RBBP4 binding#GO:0005488;histone binding#GO:0042393;protein binding#GO:0005515 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;chromatin organization#GO:0006325;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;chromatin remodeling#GO:0006338;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;cellular component organization#GO:0016043 ATPase complex#GO:1904949;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;SWI/SNF superfamily-type complex#GO:0070603;organelle lumen#GO:0043233;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;methyltransferase complex#GO:0034708;histone methyltransferase complex#GO:0035097;transferase complex#GO:1990234;transcription regulator complex#GO:0005667;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;chromatin#GO:0000785;membrane-enclosed lumen#GO:0031974;histone deacetylase complex#GO:0000118;PcG protein complex#GO:0031519;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991 HUMAN|HGNC=12948|UniProtKB=Q9HCG1 Q9HCG1 ZNF160 PTHR24377:SF1043 IP01015P-RELATED ZINC FINGER PROTEIN 160-RELATED sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=4331|UniProtKB=O94925 O94925 GLS PTHR12544:SF49 GLUTAMINASE GLUTAMINASE KIDNEY ISOFORM, MITOCHONDRIAL hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811 catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;proteinogenic amino acid metabolic process#GO:0170039;small molecule catabolic process#GO:0044282;amino acid metabolic process#GO:0006520;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 hydrolase#PC00121 HUMAN|HGNC=4460|UniProtKB=P51674 P51674 GPM6A PTHR11683:SF4 MYELIN PROTEOLIPID NEURONAL MEMBRANE GLYCOPROTEIN M6-A cellular developmental process#GO:0048869;regulation of plasma membrane bounded cell projection organization#GO:0120035;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;neurogenesis#GO:0022008;regulation of filopodium assembly#GO:0051489;regulation of cell projection organization#GO:0031344;developmental process#GO:0032502;neuron differentiation#GO:0030182;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;nervous system development#GO:0007399;biological regulation#GO:0065007;neuron projection development#GO:0031175;cellular process#GO:0009987;anatomical structure development#GO:0048856;neuron development#GO:0048666;regulation of cell projection assembly#GO:0060491;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;regulation of cellular process#GO:0050794;regulation of plasma membrane bounded cell projection assembly#GO:0120032;regulation of cellular component organization#GO:0051128;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell development#GO:0048468;regulation of cellular component biogenesis#GO:0044087;cellular component organization#GO:0016043;regulation of biological process#GO:0050789 membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;somatodendritic compartment#GO:0036477;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;intracellular anatomical structure#GO:0005622;site of polarized growth#GO:0030427;filopodium#GO:0030175;intracellular organelle#GO:0043229;axon#GO:0030424;growth cone#GO:0030426;axonal growth cone#GO:0044295;organelle#GO:0043226;cellular anatomical structure#GO:0110165;neuronal cell body#GO:0043025;cell projection#GO:0042995;distal axon#GO:0150034;plasma membrane bounded cell projection#GO:0120025;actin cytoskeleton#GO:0015629;cell body#GO:0044297;actin-based cell projection#GO:0098858 myelin protein#PC00161 HUMAN|HGNC=35462|UniProtKB=A6NKU9 A6NKU9 SPDYE3 PTHR31156:SF15 WBSCR19-LIKE PROTEIN SPEEDY PROTEIN E10-RELATED HUMAN|HGNC=1909|UniProtKB=O15335 O15335 CHAD PTHR24373:SF277 SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN CHONDROADHERIN molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=14011|UniProtKB=O95347 O95347 SMC2 PTHR43941:SF15 STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2 STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2 chromatin binding#GO:0003682;binding#GO:0005488 mitotic cell cycle#GO:0000278;cell cycle process#GO:0022402;mitotic nuclear division#GO:0140014;cell cycle#GO:0007049;sister chromatid segregation#GO:0000819;cellular component organization#GO:0016043;nuclear chromosome segregation#GO:0098813;mitotic chromosome condensation#GO:0007076;chromosome condensation#GO:0030261;organelle fission#GO:0048285;nuclear division#GO:0000280;cellular process#GO:0009987;mitotic sister chromatid segregation#GO:0000070;organelle organization#GO:0006996;mitotic cell cycle process#GO:1903047;chromosome organization#GO:0051276;cellular component organization or biogenesis#GO:0071840;chromosome segregation#GO:0007059 condensed chromosome#GO:0000793;condensin complex#GO:0000796;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;chromosome#GO:0005694;chromatin#GO:0000785;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232 HUMAN|HGNC=16205|UniProtKB=Q9BQP7 Q9BQP7 MGME1 PTHR31340:SF3 MITOCHONDRIAL GENOME MAINTENANCE EXONUCLEASE 1 MITOCHONDRIAL GENOME MAINTENANCE EXONUCLEASE 1 DNA endonuclease activity, producing 5'-phosphomonoesters#GO:0016888;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;DNA exonuclease activity#GO:0004529;hydrolase activity, acting on ester bonds#GO:0016788;DNA nuclease activity#GO:0004536;catalytic activity, acting on DNA#GO:0140097;endonuclease activity#GO:0004519;exonuclease activity#GO:0004527;hydrolase activity#GO:0016787;DNA endonuclease activity#GO:0004520;DNA exonuclease activity, producing 5'-phosphomonoesters#GO:0016895;nuclease activity#GO:0004518;5'-3' exonuclease activity#GO:0008409 HUMAN|HGNC=443|UniProtKB=Q96Q42 Q96Q42 ALS2 PTHR46089:SF3 ALSIN HOMOLOG ALSIN protein binding#GO:0005515;small GTPase binding#GO:0031267;enzyme regulator activity#GO:0030234;enzyme binding#GO:0019899;binding#GO:0005488;guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695 intracellular transport#GO:0046907;transport#GO:0006810;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;endosomal transport#GO:0016197;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192 intracellular membraneless organelle#GO:0043232;somatodendritic compartment#GO:0036477;cytoplasm#GO:0005737;neuron projection#GO:0043005;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;centrosome#GO:0005813;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;dendritic tree#GO:0097447;dendrite#GO:0030425 HUMAN|HGNC=17752|UniProtKB=O60637 O60637 TSPAN3 PTHR19282:SF48 TETRASPANIN TETRASPANIN-3 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HUMAN|HGNC=2671|UniProtKB=P14920 P14920 DAO PTHR11530:SF15 D-AMINO ACID OXIDASE D-AMINO-ACID OXIDASE oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;amino acid metabolic process#GO:0006520;small molecule catabolic process#GO:0044282;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;proteinogenic amino acid metabolic process#GO:0170039;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;microbody#GO:0042579;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;peroxisome#GO:0005777;peroxisomal matrix#GO:0005782;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 oxidase#PC00175 HUMAN|HGNC=24472|UniProtKB=Q6PGN9 Q6PGN9 PSRC1 PTHR21584:SF1 DIFFERENTIAL DISPLAY AND ACTIVATED BY P53 DDA3 /G2 S PHASE EXPRESSED 1 PROLINE_SERINE-RICH COILED-COIL PROTEIN 1 microtubule binding#GO:0008017;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;protein binding#GO:0005515 organelle organization#GO:0006996;mitotic sister chromatid segregation#GO:0000070;cellular process#GO:0009987;chromosome localization#GO:0050000;metaphase chromosome alignment#GO:0051310;chromosome segregation#GO:0007059;cellular component organization or biogenesis#GO:0071840;mitotic cell cycle process#GO:1903047;chromosome organization#GO:0051276;cell cycle#GO:0007049;nuclear chromosome segregation#GO:0098813;sister chromatid segregation#GO:0000819;cellular component organization#GO:0016043;mitotic metaphase chromosome alignment#GO:0007080;cell cycle process#GO:0022402;mitotic nuclear division#GO:0140014;mitotic cell cycle#GO:0000278;nuclear division#GO:0000280;organelle localization#GO:0051640;localization#GO:0051179;organelle fission#GO:0048285 intracellular organelle#GO:0043229;microtubule#GO:0005874;spindle microtubule#GO:0005876;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;spindle pole#GO:0000922;organelle#GO:0043226;cellular anatomical structure#GO:0110165;spindle#GO:0005819;cytoskeleton#GO:0005856;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232 HUMAN|HGNC=438|UniProtKB=P05186 P05186 ALPL PTHR11596:SF74 ALKALINE PHOSPHATASE ALKALINE PHOSPHATASE, TISSUE-NONSPECIFIC ISOZYME hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787 bone mineralization#GO:0030282;animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502;biomineral tissue development#GO:0031214;animal organ development#GO:0048513;anatomical structure development#GO:0048856;tissue development#GO:0009888;ossification#GO:0001503;multicellular organismal process#GO:0032501 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 hydrolase#PC00121;phosphatase#PC00181 HUMAN|HGNC=11583|UniProtKB=P05543 P05543 SERPINA7 PTHR11461:SF375 SERINE PROTEASE INHIBITOR, SERPIN THYROXINE-BINDING GLOBULIN serine-type endopeptidase inhibitor activity#GO:0004867;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;peptidase regulator activity#GO:0061134;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414;molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866;enzyme inhibitor activity#GO:0004857 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HUMAN|HGNC=28405|UniProtKB=Q86Y97 Q86Y97 KMT5C PTHR12977:SF11 SUPPRESSOR OF VARIEGATION 4-20-RELATED HISTONE-LYSINE N-METHYLTRANSFERASE KMT5C catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741;protein methyltransferase activity#GO:0008276;catalytic activity, acting on a protein#GO:0140096;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;histone methyltransferase activity#GO:0042054;protein-lysine N-methyltransferase activity#GO:0016279;N-methyltransferase activity#GO:0008170;lysine N-methyltransferase activity#GO:0016278;histone modifying activity#GO:0140993 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=16779|UniProtKB=Q9BYR7 Q9BYR7 KRTAP3-2 PTHR23260:SF5 KERATIN ASSOCIATED PROTEIN 3-3-RELATED KERATIN-ASSOCIATED PROTEIN 3-2 structural protein#PC00211 HUMAN|HGNC=23414|UniProtKB=Q9Y4E1 Q9Y4E1 WASHC2C PTHR21669:SF38 CAPZ-INTERACTING PROTEIN AND RELATED PROTEINS WASH COMPLEX SUBUNIT 2A-RELATED phosphatidylinositol phosphate binding#GO:1901981;lipid binding#GO:0008289;protein-containing complex binding#GO:0044877;phospholipid binding#GO:0005543;binding#GO:0005488 intracellular transport#GO:0046907;transport#GO:0006810;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;intracellular protein localization#GO:0008104;endosomal transport#GO:0016197;macromolecule localization#GO:0033036;retrograde transport, endosome to Golgi#GO:0042147;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;protein localization to organelle#GO:0033365;cytosolic transport#GO:0016482 cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;early endosome#GO:0005769;endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;vesicle#GO:0031982;intracellular vesicle#GO:0097708 scaffold/adaptor protein#PC00226 HUMAN|HGNC=30764|UniProtKB=Q9BWF2 Q9BWF2 TRAIP PTHR46569:SF1 E3 UBIQUITIN-PROTEIN LIGASE TRAIP E3 UBIQUITIN-PROTEIN LIGASE TRAIP acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 DNA metabolic process#GO:0006259;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;post-translational protein modification#GO:0043687;replication fork processing#GO:0031297;nucleobase-containing compound metabolic process#GO:0006139;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;DNA-templated DNA replication#GO:0006261;DNA replication#GO:0006260;protein modification by small protein conjugation#GO:0032446;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;protein modification process#GO:0036211 intracellular anatomical structure#GO:0005622;site of DNA damage#GO:0090734;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;chromosome#GO:0005694 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=30525|UniProtKB=Q96A59 Q96A59 MARVELD3 PTHR34609:SF17 GEO08273P1-RELATED MARVEL DOMAIN-CONTAINING PROTEIN 3 HUMAN|HGNC=4123|UniProtKB=Q10472 Q10472 GALNT1 PTHR11675:SF123 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 1 glycosyltransferase activity#GO:0016757;acetylgalactosaminyltransferase activity#GO:0008376;UDP-glycosyltransferase activity#GO:0008194;catalytic activity, acting on a protein#GO:0140096;hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;catalytic activity#GO:0003824;polypeptide N-acetylgalactosaminyltransferase activity#GO:0004653 metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;protein O-linked glycosylation#GO:0006493;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;biosynthetic process#GO:0009058 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 transferase#PC00220;glycosyltransferase#PC00111 HUMAN|HGNC=8280|UniProtKB=Q8NHB1 Q8NHB1 OR2V1 PTHR26453:SF271 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2V1 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 sensory perception#GO:0007600;nervous system process#GO:0050877;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;detection of chemical stimulus#GO:0009593;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;response to chemical#GO:0042221;response to stimulus#GO:0050896;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=7176|UniProtKB=P14780 P14780 MMP9 PTHR10201:SF30 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE-9 hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metalloendopeptidase activity#GO:0004222;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;external encapsulating structure organization#GO:0045229;extracellular structure organization#GO:0043062;metabolic process#GO:0008152;catabolic process#GO:0009056;cellular component organization#GO:0016043;cellular process#GO:0009987 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 Plasminogen activating cascade#P00050>pro-MMP-9#P01259;CCKR signaling map#P06959>MMP9#G06994;CCKR signaling map#P06959>MMP9#G07288;Alzheimer disease-presenilin pathway#P00004>Matrix metalloprotease#P00130 HUMAN|HGNC=2950|UniProtKB=Q8TE73 Q8TE73 DNAH5 PTHR10676:SF344 DYNEIN HEAVY CHAIN FAMILY PROTEIN DYNEIN AXONEMAL HEAVY CHAIN 5 isomerase activity#GO:0016853;cytoskeletal motor activity#GO:0003774;macromolecular conformation isomerase activity#GO:0120543;catalytic activity#GO:0003824;microtubule motor activity#GO:0003777;protein binding#GO:0005515;ATP-dependent activity#GO:0140657;polypeptide conformation or assembly isomerase activity#GO:0120544;binding#GO:0005488 microtubule bundle formation#GO:0001578;axonemal dynein complex assembly#GO:0070286;cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;organelle assembly#GO:0070925;cilium organization#GO:0044782;axoneme assembly#GO:0035082;microtubule cytoskeleton organization#GO:0000226;cilium-dependent cell motility#GO:0060285;protein-containing complex assembly#GO:0065003;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cell motility#GO:0048870;microtubule-based movement#GO:0007018;cell projection organization#GO:0030030;plasma membrane bounded cell projection assembly#GO:0120031;microtubule-based process#GO:0007017;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;outer dynein arm assembly#GO:0036158;cellular process#GO:0009987;cell projection assembly#GO:0030031;cilium movement involved in cell motility#GO:0060294;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607 axoneme#GO:0005930;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cilium#GO:0005929;9+2 motile cilium#GO:0097729;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;motile cilium#GO:0031514;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;axonemal dynein complex#GO:0005858;dynein complex#GO:0030286;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;outer dynein arm#GO:0036157;ciliary plasm#GO:0097014;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 Huntington disease#P00029>Dynein complex#P00774 HUMAN|HGNC=9970|UniProtKB=P35250 P35250 RFC2 PTHR11669:SF5 REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT REPLICATION FACTOR C SUBUNIT 2 catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;ATP-dependent activity#GO:0140657;ATP-dependent activity, acting on DNA#GO:0008094;catalytic activity, acting on DNA#GO:0140097 macromolecule metabolic process#GO:0043170;DNA-templated DNA replication#GO:0006261;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;nucleobase-containing compound metabolic process#GO:0006139;response to stimulus#GO:0050896;DNA replication#GO:0006260;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950 replication fork#GO:0005657;nucleus#GO:0005634;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 DNA-directed DNA polymerase#PC00018 DNA replication#P00017>RFC#P00529 HUMAN|HGNC=20445|UniProtKB=Q96DN6 Q96DN6 MBD6 PTHR16112:SF17 METHYL-CPG BINDING PROTEIN, DROSOPHILA METHYL-CPG-BINDING DOMAIN PROTEIN 6 binding#GO:0005488;chromatin binding#GO:0003682 intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=25434|UniProtKB=Q9P2M1 Q9P2M1 LRP2BP PTHR44554:SF1 LRP2-BINDING PROTEIN LRP2-BINDING PROTEIN HUMAN|Ensembl=ENSG00000288316.1|UniProtKB=A0A5F9ZH88 A0A5F9ZH88 PTHR11738:SF189 MHC CLASS I NK CELL RECEPTOR IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN-RELATED molecular transducer activity#GO:0060089;immune receptor activity#GO:0140375;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 cell surface receptor signaling pathway#GO:0007166;regulation of response to stimulus#GO:0048583;regulation of immune response#GO:0050776;cell communication#GO:0007154;immune response-regulating signaling pathway#GO:0002764;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=26573|UniProtKB=Q96LX8 Q96LX8 ZNF597 PTHR24393:SF117 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 597 DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulator activity#GO:0140110;DNA-binding transcription activator activity#GO:0001216;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=26318|UniProtKB=Q8IYI0 Q8IYI0 SHLD1 PTHR36863:SF1 SHIELDIN COMPLEX SUBUNIT 1 SHIELDIN COMPLEX SUBUNIT 1 regulation of response to stimulus#GO:0048583;regulation of DNA repair#GO:0006282;positive regulation of developmental process#GO:0051094;positive regulation of immune response#GO:0050778;regulation of response to stress#GO:0080134;negative regulation of cellular process#GO:0048523;positive regulation of leukocyte mediated immunity#GO:0002705;regulation of gene expression#GO:0010468;positive regulation of gene expression#GO:0010628;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cell activation#GO:0050867;negative regulation of DNA metabolic process#GO:0051053;positive regulation of immune effector process#GO:0002699;positive regulation of DNA repair#GO:0045739;biological regulation#GO:0065007;negative regulation of response to stimulus#GO:0048585;positive regulation of response to stimulus#GO:0048584;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of immune response#GO:0050776;regulation of double-strand break repair#GO:2000779;regulation of immune effector process#GO:0002697;positive regulation of biosynthetic process#GO:0009891;positive regulation of lymphocyte mediated immunity#GO:0002708;positive regulation of lymphocyte activation#GO:0051251;regulation of leukocyte mediated immunity#GO:0002703;negative regulation of DNA recombination#GO:0045910;positive regulation of DNA metabolic process#GO:0051054;positive regulation of double-strand break repair#GO:2000781;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of macromolecule metabolic process#GO:0060255;positive regulation of leukocyte activation#GO:0002696;negative regulation of double-strand break repair via homologous recombination#GO:2000042;positive regulation of biological process#GO:0048518;regulation of B cell activation#GO:0050864;positive regulation of immune system process#GO:0002684;regulation of multicellular organismal process#GO:0051239;positive regulation of macromolecule metabolic process#GO:0010604;regulation of DNA recombination#GO:0000018;regulation of lymphocyte mediated immunity#GO:0002706;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of cellular response to stress#GO:0080135;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of cell activation#GO:0050865;positive regulation of multicellular organismal process#GO:0051240;regulation of DNA metabolic process#GO:0051052;regulation of biological process#GO:0050789;regulation of leukocyte activation#GO:0002694;negative regulation of biological process#GO:0048519;regulation of lymphocyte activation#GO:0051249;negative regulation of metabolic process#GO:0009892;positive regulation of adaptive immune response#GO:0002821;regulation of double-strand break repair via homologous recombination#GO:0010569 chromosome#GO:0005694;site of double-strand break#GO:0035861;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;site of DNA damage#GO:0090734;membraneless organelle#GO:0043228 HUMAN|HGNC=25742|UniProtKB=Q8IWC1 Q8IWC1 MAP7D3 PTHR15073:SF5 MICROTUBULE-ASSOCIATED PROTEIN MAP7 DOMAIN-CONTAINING PROTEIN 3 cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226;microtubule-based process#GO:0007017;regulation of microtubule-based process#GO:0032886;microtubule bundle formation#GO:0001578;regulation of microtubule-based movement#GO:0060632;regulation of cellular process#GO:0050794;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;organelle organization#GO:0006996;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;cellular process#GO:0009987 microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 non-motor microtubule binding protein#PC00166 HUMAN|HGNC=18590|UniProtKB=Q9NST1 Q9NST1 PNPLA3 PTHR12406:SF22 CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 IPLA2 -RELATED 1-ACYLGLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE PNPLA3 acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;transferase activity#GO:0016740;hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689;lipase activity#GO:0016298;acyltransferase activity#GO:0016746;triacylglycerol lipase activity#GO:0004806 triglyceride catabolic process#GO:0019433;glycerolipid catabolic process#GO:0046503;organophosphate biosynthetic process#GO:0090407;lipid homeostasis#GO:0055088;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;phospholipid metabolic process#GO:0006644;homeostatic process#GO:0042592;glycerolipid metabolic process#GO:0046486;catabolic process#GO:0009056;phospholipid biosynthetic process#GO:0008654;glycerophospholipid biosynthetic process#GO:0046474;neutral lipid catabolic process#GO:0046461;triglyceride metabolic process#GO:0006641;chemical homeostasis#GO:0048878;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;acylglycerol metabolic process#GO:0006639;acylglycerol catabolic process#GO:0046464;neutral lipid metabolic process#GO:0006638;lipid catabolic process#GO:0016042;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;organophosphate metabolic process#GO:0019637;biosynthetic process#GO:0009058;glycerophospholipid metabolic process#GO:0006650;lipid biosynthetic process#GO:0008610 organelle#GO:0043226;membraneless organelle#GO:0043228;cellular anatomical structure#GO:0110165;lipid droplet#GO:0005811;intracellular membraneless organelle#GO:0043232;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 phospholipase#PC00186 HUMAN|HGNC=20369|UniProtKB=Q9H4X1 Q9H4X1 RGCC PTHR32193:SF3 REGULATOR OF CELL CYCLE RGCC REGULATOR OF CELL CYCLE RGCC enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;kinase activator activity#GO:0019209;protein kinase regulator activity#GO:0019887;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047;protein kinase activator activity#GO:0030295 cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;positive regulation of mitotic cell cycle#GO:0045931;regulation of mitotic cell cycle#GO:0007346;phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0043491;positive regulation of cellular process#GO:0048522;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;response to transforming growth factor beta#GO:0071559;regulation of immune response#GO:0050776;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of cell cycle phase transition#GO:1901987;cellular response to stimulus#GO:0051716;cellular response to transforming growth factor beta stimulus#GO:0071560;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;response to growth factor#GO:0070848;immune response-activating cell surface receptor signaling pathway#GO:0002429;regulation of cell cycle G1/S phase transition#GO:1902806;positive regulation of cell cycle G1/S phase transition#GO:1902808;cell surface receptor signaling pathway#GO:0007166;immune response-activating signaling pathway#GO:0002757;positive regulation of immune system process#GO:0002684;transforming growth factor beta receptor signaling pathway#GO:0007179;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;activation of immune response#GO:0002253;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;intracellular signaling cassette#GO:0141124;positive regulation of cell cycle#GO:0045787;regulation of cell cycle process#GO:0010564;immune system process#GO:0002376;regulation of G1/S transition of mitotic cell cycle#GO:2000045;regulation of mitotic cell cycle phase transition#GO:1901990;cellular response to growth factor stimulus#GO:0071363;response to endogenous stimulus#GO:0009719;immune response-regulating signaling pathway#GO:0002764;positive regulation of cell cycle process#GO:0090068;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;regulation of cell cycle#GO:0051726;signaling#GO:0023052 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 HUMAN|HGNC=20610|UniProtKB=O60346 O60346 PHLPP1 PTHR45752:SF58 LEUCINE-RICH REPEAT-CONTAINING PH DOMAIN LEUCINE-RICH REPEAT-CONTAINING PROTEIN PHOSPHATASE 1 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HUMAN|HGNC=19841|UniProtKB=Q6SJ96 Q6SJ96 TBPL2 PTHR10126:SF37 TATA-BOX BINDING PROTEIN TATA BOX-BINDING PROTEIN-LIKE 2 DNA-templated transcription initiation#GO:0006352;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleic acid biosynthetic process#GO:0141187 general transcription factor#PC00259;RNA metabolism protein#PC00031 General transcription by RNA polymerase I#P00022>TBP#P00657;Transcription regulation by bZIP transcription factor#P00055>TBP#P01399 HUMAN|HGNC=30455|UniProtKB=Q6UXG3 Q6UXG3 CD300LG PTHR11860:SF62 POLYMERIC-IMMUNOGLOBULIN RECEPTOR CMRF35-LIKE MOLECULE 9 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=2753|UniProtKB=Q16698 Q16698 DECR1 PTHR43658:SF14 SHORT-CHAIN DEHYDROGENASE/REDUCTASE 2,4-DIENOYL-COA REDUCTASE [(3E)-ENOYL-COA-PRODUCING], MITOCHONDRIAL catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;oxidoreductase activity#GO:0016491 lipid modification#GO:0030258;lipid metabolic process#GO:0006629;fatty acid beta-oxidation#GO:0006635;fatty acid oxidation#GO:0019395;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;monocarboxylic acid catabolic process#GO:0072329;cellular process#GO:0009987;lipid catabolic process#GO:0016042;carboxylic acid catabolic process#GO:0046395;fatty acid catabolic process#GO:0009062;lipid oxidation#GO:0034440;oxoacid metabolic process#GO:0043436;small molecule catabolic process#GO:0044282;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;monocarboxylic acid metabolic process#GO:0032787 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=13408|UniProtKB=Q14690 Q14690 PDCD11 PTHR23270:SF10 PROGRAMMED CELL DEATH PROTEIN 11 PRE-RRNA PROCESSING PROTEIN RRP5 PROTEIN RRP5 HOMOLOG U3 snoRNA binding#GO:0034511;RNA binding#GO:0003723;snoRNA binding#GO:0030515;binding#GO:0005488;nucleic acid binding#GO:0003676 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;ribonucleoprotein complex biogenesis#GO:0022613;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;cellular process#GO:0009987;endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000480;macromolecule biosynthetic process#GO:0009059;endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000479;cellular component biogenesis#GO:0044085;RNA processing#GO:0006396;maturation of SSU-rRNA#GO:0030490;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;ribosomal small subunit biogenesis#GO:0042274;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170 membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;preribosome#GO:0030684;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;small-subunit processome#GO:0032040;organelle lumen#GO:0043233 RNA metabolism protein#PC00031 HUMAN|HGNC=13816|UniProtKB=P54707 P54707 ATP12A PTHR43294:SF1 SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA POTASSIUM-TRANSPORTING ATPASE ALPHA CHAIN 2 potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;P-type ion transporter activity#GO:0015662;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;primary active transmembrane transporter activity#GO:0015399;sodium ion transmembrane transporter activity#GO:0015081;active transmembrane transporter activity#GO:0022804;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 intracellular monoatomic ion homeostasis#GO:0006873;sodium ion transport#GO:0006814;import across plasma membrane#GO:0098739;inorganic ion import across plasma membrane#GO:0099587;metal ion transport#GO:0030001;export from cell#GO:0140352;homeostatic process#GO:0042592;inorganic ion homeostasis#GO:0098771;transmembrane transport#GO:0055085;localization#GO:0051179;potassium ion homeostasis#GO:0055075;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;chemical homeostasis#GO:0048878;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;transport#GO:0006810;establishment of localization#GO:0051234;import into cell#GO:0098657;potassium ion import across plasma membrane#GO:1990573;cellular homeostasis#GO:0019725;inorganic cation import across plasma membrane#GO:0098659;intracellular chemical homeostasis#GO:0055082 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227;primary active transporter#PC00068 HUMAN|HGNC=31440|UniProtKB=Q5SQS7 Q5SQS7 SH2D4B PTHR14388:SF7 T CELL-SPECIFIC ADAPTER PROTEIN TSAD SH2 DOMAIN-CONTAINING PROTEIN 4B molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 defense/immunity protein#PC00090 HUMAN|HGNC=8978|UniProtKB=P48736 P48736 PIK3CG PTHR10048:SF34 PHOSPHATIDYLINOSITOL KINASE PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM transferase activity#GO:0016740;catalytic activity#GO:0003824;phosphatidylinositol kinase activity#GO:0052742;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;lipid kinase activity#GO:0001727;phosphotransferase activity, alcohol group as acceptor#GO:0016773 phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;glycerolipid metabolic process#GO:0046486;response to stimulus#GO:0050896;cell motility#GO:0048870;phospholipid biosynthetic process#GO:0008654;regulation of cellular process#GO:0050794;phospholipid metabolic process#GO:0006644;signaling#GO:0023052;phosphatidylinositol phosphate biosynthetic process#GO:0046854;cell communication#GO:0007154;organophosphate biosynthetic process#GO:0090407;intracellular signal transduction#GO:0035556;organophosphate metabolic process#GO:0019637;signal transduction#GO:0007165;phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0043491;glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987;glycerophospholipid metabolic process#GO:0006650;lipid biosynthetic process#GO:0008610;cell migration#GO:0016477;biological regulation#GO:0065007;biosynthetic process#GO:0009058;intracellular signaling cassette#GO:0141124;metabolic process#GO:0008152;glycerophospholipid biosynthetic process#GO:0046474;lipid metabolic process#GO:0006629 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;plasma membrane#GO:0005886;membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;extrinsic component of membrane#GO:0019898;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;transferase complex#GO:1990234 kinase#PC00137 p53 pathway feedback loops 2#P04398>PI3K#P04661;Axon guidance mediated by netrin#P00009>PI3K#P00363;Integrin signalling pathway#P00034>PI3K#P00936;Endothelin signaling pathway#P00019>PI3K#P00577;p53 pathway#P00059>PI3K#P04609;Ras Pathway#P04393>PI3K#P04567;Apoptosis signaling pathway#P00006>PI3K#P00310;PDGF signaling pathway#P00047>PI3K#P01168;Hypoxia response via HIF activation#P00030>PI3K#P00823;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>PI3K#P00900;B cell activation#P00010>PI3K#P00391;FGF signaling pathway#P00021>PI3K#P00640;T cell activation#P00053>PI3K#P01322;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PI3K#P00868;VEGF signaling pathway#P00056>PI3K#P01413;Angiogenesis#P00005>PI3K#P00236;EGF receptor signaling pathway#P00018>PI3K#P00557 HUMAN|HGNC=18958|UniProtKB=Q8TDF6 Q8TDF6 RASGRP4 PTHR23113:SF157 GUANINE NUCLEOTIDE EXCHANGE FACTOR RAS GUANYL-RELEASING PROTEIN 4 guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695 regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of response to biotic stimulus#GO:0002831;positive regulation of natural killer cell mediated immunity#GO:0002717;regulation of leukocyte mediated immunity#GO:0002703;regulation of natural killer cell mediated immunity#GO:0002715;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;positive regulation of lymphocyte mediated immunity#GO:0002708;regulation of immune effector process#GO:0002697;intracellular signal transduction#GO:0035556;Ras protein signal transduction#GO:0007265;regulation of immune response#GO:0050776;regulation of defense response#GO:0031347;positive regulation of response to stimulus#GO:0048584;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;positive regulation of immune effector process#GO:0002699;positive regulation of innate immune response#GO:0045089;regulation of innate immune response#GO:0045088;positive regulation of response to biotic stimulus#GO:0002833;positive regulation of leukocyte mediated immunity#GO:0002705;regulation of response to stress#GO:0080134;positive regulation of defense response#GO:0031349;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;response to stimulus#GO:0050896;signaling#GO:0023052;regulation of biological process#GO:0050789;regulation of lymphocyte mediated immunity#GO:0002706;regulation of response to external stimulus#GO:0032101;intracellular signaling cassette#GO:0141124;positive regulation of immune system process#GO:0002684;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;positive regulation of response to external stimulus#GO:0032103 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 guanyl-nucleotide exchange factor#PC00113 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>CalDAG-GEF#P00736 HUMAN|HGNC=14002|UniProtKB=O14519 O14519 CDK2AP1 PTHR22607:SF2 DELETED IN ORAL CANCER 1/CDK2-ASSOCIATED PROTEIN 1 CYCLIN-DEPENDENT KINASE 2-ASSOCIATED PROTEIN 1 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 kinase modulator#PC00140;kinase inhibitor#PC00139 HUMAN|HGNC=40047|UniProtKB=B5MCN3 B5MCN3 SEC14L6 PTHR23324:SF41 SEC14 RELATED PROTEIN SEC14-LIKE PROTEIN 6 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 transfer/carrier protein#PC00219 HUMAN|HGNC=17860|UniProtKB=Q8NC51 Q8NC51 SERBP1 PTHR12299:SF29 HYALURONIC ACID-BINDING PROTEIN 4 SERPINE1 MRNA-BINDING PROTEIN 1 mRNA 3'-UTR binding#GO:0003730;RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 RNA metabolism protein#PC00031 HUMAN|HGNC=15867|UniProtKB=Q9BYJ9 Q9BYJ9 YTHDF1 PTHR12357:SF65 YTH YT521-B HOMOLOGY DOMAIN-CONTAINING YTH DOMAIN-CONTAINING FAMILY PROTEIN 1 RNA binding#GO:0003723;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488;protein-RNA adaptor activity#GO:0140517 regulation of mRNA stability#GO:0043488;negative regulation of metabolic process#GO:0009892;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;regulation of biological process#GO:0050789;positive regulation of metabolic process#GO:0009893;regulation of biological quality#GO:0065008;positive regulation of macromolecule metabolic process#GO:0010604;cellular component assembly#GO:0022607;RNA destabilization#GO:0050779;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;regulation of mRNA metabolic process#GO:1903311;cellular component organization or biogenesis#GO:0071840;positive regulation of mRNA metabolic process#GO:1903313;mRNA destabilization#GO:0061157;cytoplasmic stress granule assembly#GO:0034063;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;positive regulation of mRNA catabolic process#GO:0061014;regulation of RNA metabolic process#GO:0051252;regulation of RNA stability#GO:0043487;organelle assembly#GO:0070925;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;positive regulation of catabolic process#GO:0009896;regulation of biosynthetic process#GO:0009889;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031 HUMAN|HGNC=5860|UniProtKB=P0CF74 P0CF74 IGLC6 PTHR23266:SF345 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN LAMBDA CONSTANT 6 binding#GO:0005488;antigen binding#GO:0003823 immune response#GO:0006955;adaptive immune response#GO:0002250;response to stimulus#GO:0050896;immune effector process#GO:0002252;immune system process#GO:0002376;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=132|UniProtKB=P60709 P60709 ACTB PTHR11937:SF414 ACTIN ACTIN, CYTOPLASMIC 1 structural molecule activity#GO:0005198;structural constituent of synapse#GO:0098918;protein binding#GO:0005515;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;binding#GO:0005488;kinase binding#GO:0019900;structural constituent of cytoskeleton#GO:0005200 cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;cell projection morphogenesis#GO:0048858;neurogenesis#GO:0022008;neuron differentiation#GO:0030182;developmental process#GO:0032502;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;neuron projection development#GO:0031175;axon development#GO:0061564;cellular process#GO:0009987;anatomical structure development#GO:0048856;system development#GO:0048731;axonogenesis#GO:0007409;neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell morphogenesis#GO:0000902;cell motility#GO:0048870;cell development#GO:0048468;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653 membrane#GO:0016020;H4 histone acetyltransferase complex#GO:1902562;transferase complex#GO:1990234;cytoskeleton#GO:0005856;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;chromosome#GO:0005694;plasma membrane bounded cell projection#GO:0120025;catalytic complex#GO:1902494;axon#GO:0030424;intracellular anatomical structure#GO:0005622;neuron projection#GO:0043005;chromatin#GO:0000785;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;NuA4 histone acetyltransferase complex#GO:0035267;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;actin filament#GO:0005884;histone acetyltransferase complex#GO:0000123;cell junction#GO:0030054;actin cytoskeleton#GO:0015629;cell projection#GO:0042995;organelle#GO:0043226;cellular anatomical structure#GO:0110165;synapse#GO:0045202;intracellular organelle#GO:0043229;protein acetyltransferase complex#GO:0031248;supramolecular fiber#GO:0099512;acetyltransferase complex#GO:1902493 actin and actin related protein#PC00039 Integrin signalling pathway#P00034>Actin#P00944;Huntington disease#P00029>Actin#P00807;Nicotinic acetylcholine receptor signaling pathway#P00044>Actin#P01090;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>F-actin#P00858;Cytoskeletal regulation by Rho GTPase#P00016>Actin#P00512;Alzheimer disease-presenilin pathway#P00004>actin#P00114;Wnt signaling pathway#P00057>NFAT Target Genes#G01559;Cadherin signaling pathway#P00012>F-actin#P00470 HUMAN|HGNC=49847|UniProtKB=P0DMW3 P0DMW3 SMIM10L1 PTHR34446:SF5 SMALL INTEGRAL MEMBRANE PROTEIN 10 SMALL INTEGRAL MEMBRANE PROTEIN 10-LIKE PROTEIN 1 HUMAN|HGNC=12311|UniProtKB=Q15654 Q15654 TRIP6 PTHR24212:SF7 ZYXIN/TRIP6 THYROID RECEPTOR-INTERACTING PROTEIN 6 positive regulation of non-canonical NF-kappaB signal transduction#GO:1901224;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of cellular process#GO:0048522;positive regulation of response to stimulus#GO:0048584;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;regulation of non-canonical NF-kappaB signal transduction#GO:1901222;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of cell communication#GO:0010646;signaling#GO:0023052;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;cell communication#GO:0007154 cell-substrate junction#GO:0030055;focal adhesion#GO:0005925;organelle#GO:0043226;cellular anatomical structure#GO:0110165;actin cytoskeleton#GO:0015629;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;actin filament bundle#GO:0032432;intracellular organelle#GO:0043229;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;actomyosin#GO:0042641;cell junction#GO:0030054;membraneless organelle#GO:0043228;stress fiber#GO:0001725;cytoskeleton#GO:0005856 actin or actin-binding cytoskeletal protein#PC00041;cytoskeletal protein#PC00085 HUMAN|HGNC=25244|UniProtKB=Q9UFE4 Q9UFE4 CCDC39 PTHR18962:SF0 COILED-COIL DOMAIN-CONTAINING PROTEIN 39 COILED-COIL DOMAIN-CONTAINING PROTEIN 39 inner dynein arm assembly#GO:0036159;cilium or flagellum-dependent cell motility#GO:0001539;microtubule-based transport#GO:0099111;cilium movement#GO:0003341;cilium organization#GO:0044782;cilium-dependent cell motility#GO:0060285;protein-containing complex assembly#GO:0065003;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cell projection organization#GO:0030030;left/right pattern formation#GO:0060972;microtubule-based process#GO:0007017;protein-containing complex organization#GO:0043933;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cell projection assembly#GO:0030031;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cytoskeleton organization#GO:0007010;determination of bilateral symmetry#GO:0009855;cellular component assembly#GO:0022607;pattern specification process#GO:0007389;axonemal dynein complex assembly#GO:0070286;microtubule bundle formation#GO:0001578;organelle assembly#GO:0070925;axoneme assembly#GO:0035082;localization#GO:0051179;microtubule cytoskeleton organization#GO:0000226;anatomical structure development#GO:0048856;determination of left/right symmetry#GO:0007368;cell motility#GO:0048870;microtubule-based movement#GO:0007018;developmental process#GO:0032502;transport#GO:0006810;plasma membrane bounded cell projection assembly#GO:0120031;specification of symmetry#GO:0009799;establishment of localization#GO:0051234;plasma membrane bounded cell projection organization#GO:0120036;multicellular organismal process#GO:0032501;regionalization#GO:0003002 organelle#GO:0043226;cellular anatomical structure#GO:0110165;ciliary plasm#GO:0097014;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;membraneless organelle#GO:0043228;axoneme#GO:0005930;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;cilium#GO:0005929;intracellular organelle#GO:0043229 HUMAN|HGNC=1302|UniProtKB=P57060 P57060 RWDD2B PTHR15955:SF8 RWD DOMAIN CONTAINING PROTEIN 2 RWD DOMAIN-CONTAINING PROTEIN 2B ubiquitin-protein ligase#PC00234 HUMAN|HGNC=14816|UniProtKB=Q8NGX3 Q8NGX3 OR10T2 PTHR26451:SF98 G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN OLFACTORY RECEPTOR 10T2 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;binding#GO:0005488;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;detection of chemical stimulus#GO:0009593;response to chemical#GO:0042221;response to stimulus#GO:0050896;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;sensory perception#GO:0007600;nervous system process#GO:0050877;system process#GO:0003008 membrane#GO:0016020;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021 HUMAN|HGNC=15139|UniProtKB=Q8NGF6 Q8NGF6 OR10W1 PTHR26452:SF165 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 10W1 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 sensory perception#GO:0007600;nervous system process#GO:0050877;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=8943|UniProtKB=Q99574 Q99574 SERPINI1 PTHR11461:SF50 SERINE PROTEASE INHIBITOR, SERPIN NEUROSERPIN endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414;peptidase regulator activity#GO:0061134;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;serine-type endopeptidase inhibitor activity#GO:0004867;enzyme inhibitor activity#GO:0004857;endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HUMAN|HGNC=8049|UniProtKB=P50583 P50583 NUDT2 PTHR21340:SF0 DIADENOSINE 5,5-P1,P4-TETRAPHOSPHATE PYROPHOSPHOHYDROLASE MUTT BIS(5'-NUCLEOSYL)-TETRAPHOSPHATASE [ASYMMETRICAL] hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity#GO:0016787 nucleotide biosynthetic process#GO:0009165;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;nucleoside monophosphate biosynthetic process#GO:0009124;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;ribonucleotide metabolic process#GO:0009259;purine ribonucleoside monophosphate metabolic process#GO:0009167;small molecule metabolic process#GO:0044281;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;phosphorus metabolic process#GO:0006793;purine nucleoside monophosphate metabolic process#GO:0009126;nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative biosynthetic process#GO:1901137;ribonucleoside triphosphate biosynthetic process#GO:0009201;ATP biosynthetic process#GO:0006754;metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing compound biosynthetic process#GO:0034654;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;ribose phosphate biosynthetic process#GO:0046390;organophosphate biosynthetic process#GO:0090407;nucleoside monophosphate metabolic process#GO:0009123;nucleoside triphosphate metabolic process#GO:0009141;nucleoside phosphate metabolic process#GO:0006753;purine nucleoside triphosphate biosynthetic process#GO:0009145;purine nucleoside triphosphate metabolic process#GO:0009144;primary metabolic process#GO:0044238;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;purine ribonucleoside triphosphate biosynthetic process#GO:0009206;carbohydrate derivative metabolic process#GO:1901135;purine ribonucleoside triphosphate metabolic process#GO:0009205;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;nucleoside triphosphate biosynthetic process#GO:0009142 hydrolase#PC00121 HUMAN|HGNC=42976|UniProtKB=Q6ZUA9 Q6ZUA9 MROH5 PTHR23120:SF6 MAESTRO-RELATED HEAT DOMAIN-CONTAINING MAESTRO HEAT-LIKE REPEAT FAMILY MEMBER 5 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|Ensembl=ENSG00000288413.1|UniProtKB=A0A087WW49 A0A087WW49 LOC102724971 PTHR23266:SF387 IMMUNOGLOBULIN HEAVY CHAIN IG-LIKE DOMAIN-CONTAINING PROTEIN-RELATED binding#GO:0005488;antigen binding#GO:0003823 response to stimulus#GO:0050896;adaptive immune response#GO:0002250;immune response#GO:0006955;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449;immunoglobulin mediated immune response#GO:0016064;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immune system process#GO:0002376;immune effector process#GO:0002252 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=25590|UniProtKB=Q9ULD0 Q9ULD0 OGDHL PTHR23152:SF5 2-OXOGLUTARATE DEHYDROGENASE 2-OXOGLUTARATE DEHYDROGENASE-LIKE, MITOCHONDRIAL oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the aldehyde or oxo group of donors#GO:0016903;catalytic activity#GO:0003824 metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091;cellular respiration#GO:0045333;energy derivation by oxidation of organic compounds#GO:0015980;aerobic respiration#GO:0009060;tricarboxylic acid cycle#GO:0006099;primary metabolic process#GO:0044238;cellular process#GO:0009987 transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;oxidoreductase complex#GO:1990204;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226 oxidoreductase#PC00176;dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=8155|UniProtKB=P41146 P41146 OPRL1 PTHR24229:SF11 NEUROPEPTIDES RECEPTOR NOCICEPTIN RECEPTOR peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;binding#GO:0005488;G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888;neuropeptide binding#GO:0042923;peptide binding#GO:0042277;molecular transducer activity#GO:0060089 signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;system process#GO:0003008;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;sensory perception of pain#GO:0019233;neuropeptide signaling pathway#GO:0007218;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;sensory perception#GO:0007600;nervous system process#GO:0050877;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;neuron projection#GO:0043005;membrane#GO:0016020 G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GoPCR#P00725;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711 HUMAN|HGNC=215|UniProtKB=P78325 P78325 ADAM8 PTHR11905:SF20 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 8 endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;cell adhesion molecule binding#GO:0050839;catalytic activity#GO:0003824;protein binding#GO:0005515;hydrolase activity#GO:0016787;metallopeptidase activity#GO:0008237;binding#GO:0005488 regulation of protein catabolic process#GO:0042176;positive regulation of protein catabolic process#GO:0045732;protein metabolic process#GO:0019538;regulation of cell motility#GO:2000145;inflammatory response#GO:0006954;regulation of cellular process#GO:0050794;regulation of cell-cell adhesion#GO:0022407;regulation of immune system process#GO:0002682;regulation of macromolecule metabolic process#GO:0060255;regulation of leukocyte migration#GO:0002685;primary metabolic process#GO:0044238;regulation of catabolic process#GO:0009894;defense response#GO:0006952;positive regulation of locomotion#GO:0040017;positive regulation of catabolic process#GO:0009896;macromolecule metabolic process#GO:0043170;regulation of cell migration#GO:0030334;regulation of locomotion#GO:0040012;biological regulation#GO:0065007;regulation of cell adhesion#GO:0030155;positive regulation of cell migration#GO:0030335;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of metabolic process#GO:0009893;positive regulation of protein metabolic process#GO:0051247;proteolysis#GO:0006508;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;positive regulation of cell motility#GO:2000147;regulation of proteolysis#GO:0030162;metabolic process#GO:0008152;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;regulation of protein metabolic process#GO:0051246;positive regulation of immune system process#GO:0002684;response to stress#GO:0006950 metalloprotease#PC00153;protease#PC00190 HUMAN|HGNC=6355|UniProtKB=Q9C0H6 Q9C0H6 KLHL4 PTHR24412:SF74 KELCH PROTEIN KELCH-LIKE PROTEIN 4 ubiquitin-like ligase-substrate adaptor activity#GO:1990756;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;enzyme-substrate adaptor activity#GO:0140767 catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163 ubiquitin ligase complex#GO:0000151;Cul3-RING ubiquitin ligase complex#GO:0031463;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;cullin-RING ubiquitin ligase complex#GO:0031461 scaffold/adaptor protein#PC00226 HUMAN|HGNC=2478|UniProtKB=Q15828 Q15828 CST6 PTHR47033:SF1 CYSTATIN-M CYSTATIN-M enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;cysteine-type endopeptidase inhibitor activity#GO:0004869;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414;peptidase regulator activity#GO:0061134;endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772;enzyme inhibitor activity#GO:0004857 developmental process#GO:0032502;epidermis development#GO:0008544;animal gross anatomical part developmental process#GO:0160108;tissue development#GO:0009888;anatomical structure development#GO:0048856 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=11806|UniProtKB=Q8IVF5 Q8IVF5 TIAM2 PTHR46001:SF5 TIAM (MAMMALIAN TUMOR INVASION AND METASTASIS FACTOR) HOMOLOG RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR TIAM2 guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234 cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of cellular component organization#GO:0051128;regulation of developmental process#GO:0050793;signaling#GO:0023052;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of neuron projection development#GO:0010975;intracellular signaling cassette#GO:0141124;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;regulation of cell projection organization#GO:0031344;regulation of anatomical structure morphogenesis#GO:0022603;regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of axonogenesis#GO:0050770 synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell junction#GO:0030054;membrane#GO:0016020 HUMAN|HGNC=8680|UniProtKB=Q9Y5F3 Q9Y5F3 PCDHB1 PTHR24028:SF118 CADHERIN-87A PROTOCADHERIN BETA-1 cellular process#GO:0009987;cell adhesion#GO:0007155 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 cell adhesion molecule#PC00069;cadherin#PC00057 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HUMAN|HGNC=28802|UniProtKB=Q32NC0 Q32NC0 RMP24 PTHR31402:SF2 UPF0711 PROTEIN C18ORF21 RIBONUCLEASE MRP PROTEIN SUBUNIT P24 HUMAN|HGNC=500|UniProtKB=P15144 P15144 ANPEP PTHR11533:SF172 PROTEASE M1 ZINC METALLOPROTEASE AMINOPEPTIDASE N metallopeptidase activity#GO:0008237;exopeptidase activity#GO:0008238;metalloaminopeptidase activity#GO:0070006;hydrolase activity#GO:0016787;metalloexopeptidase activity#GO:0008235;catalytic activity#GO:0003824;aminopeptidase activity#GO:0004177;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096 protein maturation#GO:0051604;gene expression#GO:0010467;multicellular organismal process#GO:0032501;hormone metabolic process#GO:0042445;blood circulation#GO:0008015;biological regulation#GO:0065007;biosynthetic process#GO:0009058;regulation of systemic arterial blood pressure#GO:0003073;regulation of blood pressure#GO:0008217;protein processing#GO:0016485;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;peptide hormone processing#GO:0016486;peptide catabolic process#GO:0043171;macromolecule metabolic process#GO:0043170;system process#GO:0003008;metabolic process#GO:0008152;catabolic process#GO:0009056;primary metabolic process#GO:0044238;regulation of hormone levels#GO:0010817;protein metabolic process#GO:0019538;signaling receptor ligand precursor processing#GO:0140448;regulation of biological quality#GO:0065008;peptide metabolic process#GO:0006518;circulatory system process#GO:0003013;proteolysis#GO:0006508 extracellular region#GO:0005576;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 protease#PC00190;metalloprotease#PC00153 HUMAN|HGNC=10079|UniProtKB=Q9HAU8 Q9HAU8 RNPEPL1 PTHR45726:SF2 LEUKOTRIENE A-4 HYDROLASE AMINOPEPTIDASE RNPEPL1 peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;metalloexopeptidase activity#GO:0008235;catalytic activity#GO:0003824;aminopeptidase activity#GO:0004177;exopeptidase activity#GO:0008238;metalloaminopeptidase activity#GO:0070006;hydrolase activity#GO:0016787;metallopeptidase activity#GO:0008237 cellular process#GO:0009987;metabolic process#GO:0008152;proteolysis#GO:0006508;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 HUMAN|HGNC=14161|UniProtKB=Q9BV90 Q9BV90 SNRNP25 PTHR14942:SF21 U11/U12 SMALL NUCLEAR RIBONUCLEOPROTEIN 25 KDA PROTEIN U11_U12 SMALL NUCLEAR RIBONUCLEOPROTEIN 25 KDA PROTEIN intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634;spliceosomal complex#GO:0005681;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;U12-type spliceosomal complex#GO:0005689;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904 HUMAN|HGNC=948|UniProtKB=O94812 O94812 BAIAP3 PTHR45999:SF1 UNC-13-4A, ISOFORM B BAI1-ASSOCIATED PROTEIN 3 protein binding#GO:0005515;SNARE binding#GO:0000149;binding#GO:0005488 regulation of neurotransmitter transport#GO:0051588;positive regulation of synaptic transmission#GO:0050806;positive regulation of secretion#GO:0051047;regulation of signaling#GO:0023051;regulation of secretion#GO:0051046;positive regulation of signaling#GO:0023056;regulation of exocytosis#GO:0017157;regulation of secretion by cell#GO:1903530;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;positive regulation of cell communication#GO:0010647;regulation of neurotransmitter secretion#GO:0046928;regulation of cellular process#GO:0050794;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;regulation of transport#GO:0051049;regulation of localization#GO:0032879;positive regulation of secretion by cell#GO:1903532;positive regulation of cellular process#GO:0048522;positive regulation of transport#GO:0051050;positive regulation of biological process#GO:0048518;regulation of trans-synaptic signaling#GO:0099177;biological regulation#GO:0065007 cell periphery#GO:0071944;secretory vesicle#GO:0099503;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;vesicle membrane#GO:0012506;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;plasma membrane#GO:0005886;cytoplasmic vesicle membrane#GO:0030659;trans-Golgi network membrane#GO:0032588;late endosome#GO:0005770;endomembrane system#GO:0012505;late endosome membrane#GO:0031902;Golgi apparatus#GO:0005794;recycling endosome#GO:0055037;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;recycling endosome membrane#GO:0055038;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;endosome membrane#GO:0010008;endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=13533|UniProtKB=Q9NTI2 Q9NTI2 ATP8A2 PTHR24092:SF98 PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE PHOSPHOLIPID-TRANSPORTING ATPASE IB intramembrane lipid carrier activity#GO:0140303;lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104;ATP-dependent activity#GO:0140657;ATPase-coupled intramembrane lipid carrier activity#GO:0140326;transporter activity#GO:0005215 cellular process#GO:0009987;macromolecule localization#GO:0033036;phospholipid transport#GO:0015914;biological regulation#GO:0065007;phospholipid translocation#GO:0045332;membrane organization#GO:0061024;nervous system development#GO:0007399;lipid transport#GO:0006869;multicellular organismal process#GO:0032501;developmental process#GO:0032502;neuron differentiation#GO:0030182;transport#GO:0006810;regulation of membrane lipid distribution#GO:0097035;neurogenesis#GO:0022008;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;establishment of localization#GO:0051234;cellular component organization#GO:0016043;lipid translocation#GO:0034204;cell development#GO:0048468;organophosphate ester transport#GO:0015748;cell differentiation#GO:0030154;generation of neurons#GO:0048699;lipid localization#GO:0010876;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;neuron development#GO:0048666;regulation of biological quality#GO:0065008;localization#GO:0051179;anatomical structure development#GO:0048856 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 primary active transporter#PC00068;transporter#PC00227 HUMAN|HGNC=6333|UniProtKB=Q14954 Q14954 KIR2DS1 PTHR11738:SF189 MHC CLASS I NK CELL RECEPTOR IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN-RELATED transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;immune receptor activity#GO:0140375 cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;regulation of response to stimulus#GO:0048583;regulation of immune response#GO:0050776;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;cellular process#GO:0009987;immune response-regulating signaling pathway#GO:0002764;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=33722|UniProtKB=Q66K41 Q66K41 ZNF385C PTHR23067:SF6 DOUBLE-STRANDED RNA-BINDING ZINC FINGER PROTEIN ZINC FINGER PROTEIN 385C membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=16270|UniProtKB=O95907 O95907 SLC16A8 PTHR11360:SF26 MONOCARBOXYLATE TRANSPORTER MONOCARBOXYLATE TRANSPORTER 3 monocarboxylic acid transmembrane transporter activity#GO:0008028;transporter activity#GO:0005215;carboxylic acid transmembrane transporter activity#GO:0046943;transmembrane transporter activity#GO:0022857 cell periphery#GO:0071944;basal plasma membrane#GO:0009925;membrane#GO:0016020;basal part of cell#GO:0045178;basolateral plasma membrane#GO:0016323;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590 transporter#PC00227 HUMAN|HGNC=26305|UniProtKB=Q6P3V2 Q6P3V2 ZNF585A PTHR24376:SF245 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 585A gene-specific transcriptional regulator#PC00264;zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=14511|UniProtKB=P82663 P82663 MRPS25 PTHR13274:SF2 MITOCHONDRIAL RIBOSOMAL PROTEIN S25 SMALL RIBOSOMAL SUBUNIT PROTEIN MS25 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;mitochondrial gene expression#GO:0140053;metabolic process#GO:0008152;translation#GO:0006412;gene expression#GO:0010467;mitochondrial translation#GO:0032543;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 mitochondrial small ribosomal subunit#GO:0005763;membraneless organelle#GO:0043228;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;membrane-enclosed lumen#GO:0031974;intracellular anatomical structure#GO:0005622;mitochondrial ribosome#GO:0005761;organellar ribosome#GO:0000313;membrane-bounded organelle#GO:0043227;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;small ribosomal subunit#GO:0015935;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;mitochondrion#GO:0005739;organelle lumen#GO:0043233 ribosomal protein#PC00202 HUMAN|HGNC=31972|UniProtKB=A7E2F4 A7E2F4 GOLGA8A PTHR10881:SF64 GOLGIN SUBFAMILY A MEMBER-RELATED GOLGIN SUBFAMILY A MEMBER 8A organelle organization#GO:0006996;cellular component organization#GO:0016043;Golgi organization#GO:0007030;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;endomembrane system organization#GO:0010256 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;Golgi stack#GO:0005795;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;organelle membrane#GO:0031090;cis-Golgi network#GO:0005801;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;endomembrane system#GO:0012505;Golgi cisterna#GO:0031985;cytoplasm#GO:0005737;Golgi cis cisterna#GO:0000137 membrane traffic protein#PC00150 HUMAN|HGNC=12186|UniProtKB=A0A0B4J2E0 A0A0B4J2E0 TRBV12-4 PTHR23268:SF14 T-CELL RECEPTOR BETA CHAIN T CELL RECEPTOR BETA VARIABLE 12-3-RELATED cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=2473|UniProtKB=P01037 P01037 CST1 PTHR46186:SF5 CYSTATIN CYSTATIN-SN enzyme inhibitor activity#GO:0004857;molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866;peptidase regulator activity#GO:0061134;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;cysteine-type endopeptidase inhibitor activity#GO:0004869;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;extracellular region#GO:0005576;vesicle#GO:0031982 protease inhibitor#PC00191 HUMAN|HGNC=14273|UniProtKB=Q8N9W6 Q8N9W6 BOLL PTHR11176:SF10 BOULE-RELATED PROTEIN BOULE-LIKE translation regulator activity#GO:0045182 positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;negative regulation of catabolic process#GO:0009895;positive regulation of translation#GO:0045727;regulation of RNA stability#GO:0043487;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;positive regulation of gene expression#GO:0010628;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of RNA catabolic process#GO:1902369;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;RNA stabilization#GO:0043489;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of biological quality#GO:0065008;positive regulation of protein metabolic process#GO:0051247;regulation of translational initiation#GO:0006446;regulation of mRNA stability#GO:0043488;negative regulation of metabolic process#GO:0009892;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of mRNA metabolic process#GO:1903311;negative regulation of RNA metabolic process#GO:0051253;positive regulation of macromolecule metabolic process#GO:0010604;mRNA stabilization#GO:0048255;regulation of protein metabolic process#GO:0051246;positive regulation of biological process#GO:0048518 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 RNA metabolism protein#PC00031 HUMAN|HGNC=11918|UniProtKB=P43489 P43489 TNFRSF4 PTHR47881:SF1 TUMOR NECROSIS FACTOR RECEPTOR SUBFAMILY MEMBER 4 TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 4 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;death receptor activity#GO:0005035 inflammatory response#GO:0006954;response to stress#GO:0006950;defense response#GO:0006952;response to stimulus#GO:0050896 cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020;plasma membrane#GO:0005886;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552 transmembrane signal receptor#PC00197 HUMAN|HGNC=5185|UniProtKB=O00198 O00198 HRK PTHR15056:SF0 ACTIVATOR OF APOPTOSIS HARAKIRI ACTIVATOR OF APOPTOSIS HARAKIRI positive regulation of programmed cell death#GO:0043068;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;biological regulation#GO:0065007;regulation of programmed cell death#GO:0043067;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of mitochondrion organization#GO:0010821;positive regulation of organelle organization#GO:0010638;positive regulation of apoptotic process#GO:0043065;regulation of release of cytochrome c from mitochondria#GO:0090199;regulation of apoptotic process#GO:0042981;positive regulation of cellular component organization#GO:0051130 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739 HUMAN|HGNC=29364|UniProtKB=Q9C0D5 Q9C0D5 TANC1 PTHR24166:SF23 ROLLING PEBBLES, ISOFORM B PROTEIN TANC1 regulation of biological process#GO:0050789;regulation of postsynapse organization#GO:0099175;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of synapse organization#GO:0050807;regulation of synapse structure or activity#GO:0050803;regulation of biological quality#GO:0065008 postsynaptic density#GO:0014069;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;cell junction#GO:0030054;postsynapse#GO:0098794;intracellular membraneless organelle#GO:0043232;neuron to neuron synapse#GO:0098984;cellular anatomical structure#GO:0110165;synapse#GO:0045202;glutamatergic synapse#GO:0098978;asymmetric synapse#GO:0032279;organelle#GO:0043226;postsynaptic specialization#GO:0099572 scaffold/adaptor protein#PC00226 HUMAN|HGNC=28724|UniProtKB=Q8IW19 Q8IW19 APLF PTHR21315:SF2 APRATAXIN AND PNK-LIKE FACTOR-RELATED APRATAXIN AND PNK-LIKE FACTOR DNA nuclease activity#GO:0004536;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;endonuclease activity#GO:0004519;nuclease activity#GO:0004518;DNA endonuclease activity#GO:0004520;catalytic activity, acting on DNA#GO:0140097 response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;response to stress#GO:0006950;nucleic acid metabolic process#GO:0090304;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;double-strand break repair#GO:0006302;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;DNA damage response#GO:0006974;cellular response to stress#GO:0033554 nucleus#GO:0005634;site of double-strand break#GO:0035861;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;site of DNA damage#GO:0090734;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 HUMAN|HGNC=24968|UniProtKB=Q96KP1 Q96KP1 EXOC2 PTHR13043:SF1 EXOCYST COMPLEX COMPONENT SEC5 EXOCYST COMPLEX COMPONENT 2 transport#GO:0006810;secretion by cell#GO:0032940;exocytosis#GO:0006887;localization#GO:0051179;secretion#GO:0046903;establishment of localization#GO:0051234;cellular process#GO:0009987;export from cell#GO:0140352;vesicle-mediated transport#GO:0016192 vesicle tethering complex#GO:0099023;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;exocyst#GO:0000145;cell cortex#GO:0005938;cell periphery#GO:0071944 Ras Pathway#P04393>Sec5#P04545 HUMAN|HGNC=30684|UniProtKB=O14907 O14907 TAX1BP3 PTHR48620:SF1 TAX1-BINDING PROTEIN 3 TAX1-BINDING PROTEIN 3 HUMAN|HGNC=667|UniProtKB=P61586 P61586 RHOA PTHR24072:SF153 RHO FAMILY GTPASE TRANSFORMING PROTEIN RHOA hydrolase activity#GO:0016787;small molecule binding#GO:0036094;anion binding#GO:0043168;GTPase activity#GO:0003924;ion binding#GO:0043167;ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleotide binding#GO:0000166;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;protein binding#GO:0005515;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;kinase binding#GO:0019900;nucleoside phosphate binding#GO:1901265;enzyme binding#GO:0019899;guanyl nucleotide binding#GO:0019001;protein kinase binding#GO:0019901;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;hydrolase activity, acting on acid anhydrides#GO:0016817 cell communication#GO:0007154;supramolecular fiber organization#GO:0097435;intracellular signal transduction#GO:0035556;actin filament-based process#GO:0030029;regulation of cytoskeleton organization#GO:0051493;cell motility#GO:0048870;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;actin filament bundle assembly#GO:0051017;cellular response to stimulus#GO:0051716;actin filament organization#GO:0007015;regulation of actin filament-based process#GO:0032970;cell migration#GO:0016477;contractile actin filament bundle assembly#GO:0030038;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;stress fiber assembly#GO:0043149;Rho protein signal transduction#GO:0007266;response to stimulus#GO:0050896;regulation of cellular component organization#GO:0051128;actomyosin structure organization#GO:0031032;signaling#GO:0023052;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;actin filament bundle organization#GO:0061572;regulation of organelle organization#GO:0033043;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;regulation of actin cytoskeleton organization#GO:0032956;intracellular signaling cassette#GO:0141124;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;signal transduction#GO:0007165;cellular process#GO:0009987 cell periphery#GO:0071944;neuron projection#GO:0043005;membrane#GO:0016020;cytosol#GO:0005829;cytoplasm#GO:0005737;cell division site#GO:0032153;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;plasma membrane region#GO:0098590;cleavage furrow#GO:0032154;cell junction#GO:0030054;dendritic spine#GO:0043197;postsynapse#GO:0098794;plasma membrane bounded cell projection#GO:0120025;neuron spine#GO:0044309;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;synapse#GO:0045202;dendritic tree#GO:0097447;dendrite#GO:0030425;intracellular anatomical structure#GO:0005622 G-protein#PC00020;small GTPase#PC00208 Integrin signalling pathway#P00034>Rho#P00948;Ras Pathway#P04393>Rho#P04578;CCKR signaling map#P06959>RHOA-GDP#P07019;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>RhoA#P00740;Axon guidance mediated by semaphorins#P00007>Rho#P00341;CCKR signaling map#P06959>RHOA-GTP#P07188;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Rho#P00860;Angiotensin II-stimulated signaling through G proteins and beta-arrestin#P05911>RhoA#P05938;Angiogenesis#P00005>GTPase#P00254 HUMAN|HGNC=30932|UniProtKB=Q6GPH4 Q6GPH4 XAF1 PTHR16295:SF17 TRAF-TYPE ZINC FINGER PROTEIN-RELATED XIAP-ASSOCIATED FACTOR 1 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739 HUMAN|HGNC=5007|UniProtKB=Q01581 Q01581 HMGCS1 PTHR43323:SF4 3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE HYDROXYMETHYLGLUTARYL-COA SYNTHASE, CYTOPLASMIC catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746 small molecule metabolic process#GO:0044281;nucleobase-containing compound metabolic process#GO:0006139;nucleoside phosphate metabolic process#GO:0006753;organophosphate metabolic process#GO:0019637;primary metabolic process#GO:0044238;sulfur compound metabolic process#GO:0006790;phosphorus metabolic process#GO:0006793;cellular process#GO:0009987;purine-containing compound metabolic process#GO:0072521;acyl-CoA metabolic process#GO:0006637;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;acetyl-CoA metabolic process#GO:0006084 Cholesterol biosynthesis#P00014>Hydroxymethyl glutaryl CoA synthase#P00498 HUMAN|HGNC=30404|UniProtKB=Q96GA7 Q96GA7 SDSL PTHR48078:SF16 THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED SERINE DEHYDRATASE-LIKE lyase activity#GO:0016829;catalytic activity#GO:0003824 proteinogenic amino acid biosynthetic process#GO:0170038;amino acid biosynthetic process#GO:0008652;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;small molecule biosynthetic process#GO:0044283;branched-chain amino acid biosynthetic process#GO:0009082;proteinogenic amino acid metabolic process#GO:0170039;small molecule metabolic process#GO:0044281;amino acid metabolic process#GO:0006520;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;carboxylic acid biosynthetic process#GO:0046394;aspartate family amino acid biosynthetic process#GO:0009067;cellular process#GO:0009987 dehydratase#PC00091;lyase#PC00144 HUMAN|HGNC=30938|UniProtKB=Q86Y13 Q86Y13 DZIP3 PTHR15727:SF4 RING FINGER PROTEIN 214 E3 UBIQUITIN-PROTEIN LIGASE DZIP3 ubiquitin-protein transferase activity#GO:0004842;protein binding#GO:0005515;RNA binding#GO:0003723;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;nucleic acid binding#GO:0003676;modification-dependent protein binding#GO:0140030;binding#GO:0005488;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;polyubiquitin modification-dependent protein binding#GO:0031593 macromolecule metabolic process#GO:0043170;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;cellular process#GO:0009987;protein modification process#GO:0036211;primary metabolic process#GO:0044238 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=8950|UniProtKB=P35237 P35237 SERPINB6 PTHR11461:SF204 SERINE PROTEASE INHIBITOR, SERPIN SERPIN B6 molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866;enzyme inhibitor activity#GO:0004857;serine-type endopeptidase inhibitor activity#GO:0004867;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;peptidase regulator activity#GO:0061134;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HUMAN|HGNC=25489|UniProtKB=Q9ULM3 Q9ULM3 YEATS2 PTHR23195:SF7 YEATS DOMAIN YEATS DOMAIN-CONTAINING PROTEIN 2 protein binding#GO:0005515;binding#GO:0005488;histone binding#GO:0042393 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;chromatin organization#GO:0006325;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;chromatin remodeling#GO:0006338;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355 chromosome#GO:0005694;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;protein acetyltransferase complex#GO:0031248;SAGA-type complex#GO:0070461;acetyltransferase complex#GO:1902493;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;chromatin#GO:0000785;NuA4 histone acetyltransferase complex#GO:0035267;protein-containing complex#GO:0032991;H4 histone acetyltransferase complex#GO:1902562;intracellular membraneless organelle#GO:0043232;transferase complex#GO:1990234;membraneless organelle#GO:0043228;histone acetyltransferase complex#GO:0000123;intracellular protein-containing complex#GO:0140535 general transcription factor#PC00259 HUMAN|HGNC=23290|UniProtKB=Q9H009 Q9H009 NACA2 PTHR21713:SF2 NASCENT POLYPEPTIDE ASSOCIATED COMPLEX ALPHA SUBUNIT-RELATED NASCENT POLYPEPTIDE-ASSOCIATED COMPLEX SUBUNIT ALPHA-2 cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of protein localization to membrane#GO:0090150;protein targeting#GO:0006605;localization within membrane#GO:0051668;protein targeting to membrane#GO:0006612;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=20325|UniProtKB=Q9Y5T4 Q9Y5T4 DNAJC15 PTHR12763:SF7 FAMILY NOT NAMED DNAJ HOMOLOG SUBFAMILY C MEMBER 15 ATPase activator activity#GO:0001671;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 localization#GO:0051179;transmembrane transport#GO:0055085;cellular localization#GO:0051641;protein transport#GO:0015031;mitochondrial transmembrane transport#GO:1990542;mitochondrial transport#GO:0006839;protein localization to organelle#GO:0033365;protein localization to mitochondrion#GO:0070585;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;intracellular protein transmembrane transport#GO:0065002;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;protein transmembrane import into intracellular organelle#GO:0044743;transport#GO:0006810;intracellular protein transport#GO:0006886;protein transmembrane transport#GO:0071806;mitochondrial protein import pathway#GO:7770058;protein import into mitochondrial matrix#GO:0030150;macromolecule localization#GO:0033036;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987 organelle membrane#GO:0031090;inner mitochondrial membrane protein complex#GO:0098800;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;mitochondrial membrane#GO:0031966;TIM23 mitochondrial import inner membrane translocase complex#GO:0005744;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrial inner membrane#GO:0005743;membrane-enclosed lumen#GO:0031974;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;membrane protein complex#GO:0098796;organelle envelope#GO:0031967;organelle lumen#GO:0043233 HUMAN|HGNC=5836|UniProtKB=A0A0C4DH24 A0A0C4DH24 IGKV6-21 PTHR23267:SF528 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN KAPPA VARIABLE 6-21-RELATED immune response#GO:0006955;immune system process#GO:0002376;response to stimulus#GO:0050896 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=21995|UniProtKB=Q8NA54 Q8NA54 IQUB PTHR21074:SF0 IQ AND UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN IQ MOTIF AND UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN endomembrane system#GO:0012505;cytoplasm#GO:0005737;secretory vesicle#GO:0099503;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;acrosomal vesicle#GO:0001669;cilium#GO:0005929;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;motile cilium#GO:0031514;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;cell projection#GO:0042995;intracellular vesicle#GO:0097708;vesicle#GO:0031982 HUMAN|HGNC=28006|UniProtKB=Q8WVK7 Q8WVK7 SKA2 PTHR32017:SF3 SPINDLE AND KINETOCHORE-ASSOCIATED PROTEIN 2 SPINDLE AND KINETOCHORE-ASSOCIATED PROTEIN 2 protein binding#GO:0005515;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;microtubule binding#GO:0008017 cell cycle process#GO:0022402;cellular process#GO:0009987;chromosome segregation#GO:0007059;cell cycle#GO:0007049;mitotic cell cycle#GO:0000278 intracellular organelle#GO:0043229;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;spindle microtubule#GO:0005876;microtubule#GO:0005874;kinetochore#GO:0000776;chromosome#GO:0005694;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoskeleton#GO:0005856;chromosome, centromeric region#GO:0000775;condensed chromosome#GO:0000793;spindle#GO:0005819;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;outer kinetochore#GO:0000940;condensed chromosome, centromeric region#GO:0000779;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080 HUMAN|HGNC=7953|UniProtKB=P47972 P47972 NPTX2 PTHR19277:SF1 PENTRAXIN NEURONAL PENTRAXIN-2 scaffold/adaptor protein#PC00226 HUMAN|HGNC=10445|UniProtKB=Q92600 Q92600 CNOT9 PTHR12262:SF0 CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 9 CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 9 positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;RNA destabilization#GO:0050779;regulation of mRNA metabolic process#GO:1903311;metabolic process#GO:0008152;mRNA destabilization#GO:0061157;macromolecule catabolic process#GO:0009057;positive regulation of mRNA metabolic process#GO:1903313;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;regulation of mRNA stability#GO:0043488;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;negative regulation of gene expression#GO:0010629;regulation of biological quality#GO:0065008;positive regulation of metabolic process#GO:0009893;RNA metabolic process#GO:0016070;RNA catabolic process#GO:0006401;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;nucleic acid catabolic process#GO:0141188;nucleobase-containing compound catabolic process#GO:0034655;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;macromolecule metabolic process#GO:0043170;nuclear-transcribed mRNA catabolic process#GO:0000956;positive regulation of catabolic process#GO:0009896;regulation of biosynthetic process#GO:0009889;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;positive regulation of RNA metabolic process#GO:0051254;nuclear-transcribed mRNA poly(A) tail shortening#GO:0000289;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of mRNA catabolic process#GO:0061014;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of RNA metabolic process#GO:0051252;regulation of RNA stability#GO:0043487 ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;organelle#GO:0043226;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;CCR4-NOT complex#GO:0030014;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;P-body#GO:0000932;intracellular organelle#GO:0043229 HUMAN|HGNC=8489|UniProtKB=Q9UBD5 Q9UBD5 ORC3 PTHR12748:SF1 ORIGIN RECOGNITION COMPLEX SUBUNIT 3 ORIGIN RECOGNITION COMPLEX SUBUNIT 3 binding#GO:0005488;nucleic acid binding#GO:0003676;DNA replication origin binding#GO:0003688;DNA binding#GO:0003677;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;sequence-specific DNA binding#GO:0043565 macromolecule metabolic process#GO:0043170;DNA-templated DNA replication#GO:0006261;DNA replication initiation#GO:0006270;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;DNA replication#GO:0006260;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;nuclear pre-replicative complex#GO:0005656;origin recognition complex#GO:0000808;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;nuclear origin of replication recognition complex#GO:0005664;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;protein-DNA complex#GO:0032993;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;DNA replication preinitiation complex#GO:0031261;chromosome#GO:0005694;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;pre-replicative complex#GO:0036387;intracellular organelle lumen#GO:0070013 replication origin binding protein#PC00199;DNA metabolism protein#PC00009 HUMAN|HGNC=28788|UniProtKB=Q8NCB2 Q8NCB2 CAMKV PTHR24347:SF18 SERINE/THREONINE-PROTEIN KINASE CAM KINASE-LIKE VESICLE-ASSOCIATED PROTEIN catalytic activity, acting on a protein#GO:0140096;calmodulin binding#GO:0005516;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein binding#GO:0005515;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;binding#GO:0005488;calcium/calmodulin-dependent protein kinase activity#GO:0004683 cell communication#GO:0007154;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165 cell junction#GO:0030054;cellular anatomical structure#GO:0110165;synapse#GO:0045202;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=7700|UniProtKB=O43674 O43674 NDUFB5 PTHR13178:SF0 NADH-UBIQUINONE OXIDOREDUCTASE SGDH SUBUNIT NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 5, MITOCHONDRIAL cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;respiratory chain complex#GO:0098803;membrane#GO:0016020;oxidoreductase complex#GO:1990204;membrane protein complex#GO:0098796;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;respiratory chain complex I#GO:0045271;catalytic complex#GO:1902494 oxidoreductase#PC00176 HUMAN|HGNC=25413|UniProtKB=Q6UWL2 Q6UWL2 SUSD1 PTHR24051:SF5 SUSHI DOMAIN-CONTAINING PROTEIN 1 SUSHI DOMAIN-CONTAINING PROTEIN 1 extracellular matrix glycoprotein#PC00100 HUMAN|HGNC=811|UniProtKB=O14983 O14983 ATP2A1 PTHR42861:SF24 CALCIUM-TRANSPORTING ATPASE SARCOPLASMIC_ENDOPLASMIC RETICULUM CALCIUM ATPASE 1 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;P-type ion transporter activity#GO:0015662;ATP-dependent activity#GO:0140657;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATPase-coupled transmembrane transporter activity#GO:0042626;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085 establishment of localization#GO:0051234;cellular homeostasis#GO:0019725;calcium ion transport#GO:0006816;intracellular calcium ion homeostasis#GO:0006874;intracellular chemical homeostasis#GO:0055082;intracellular monoatomic cation homeostasis#GO:0030003;transport#GO:0006810;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;calcium ion homeostasis#GO:0055074;inorganic ion homeostasis#GO:0098771;homeostatic process#GO:0042592;metal ion transport#GO:0030001;calcium ion transmembrane transport#GO:0070588;intracellular monoatomic ion homeostasis#GO:0006873 membrane#GO:0016020;cellular anatomical structure#GO:0110165 primary active transporter#PC00068 HUMAN|HGNC=33781|UniProtKB=Q6ZNF0 Q6ZNF0 ACP7 PTHR45867:SF3 PURPLE ACID PHOSPHATASE ACID PHOSPHATASE TYPE 7 phosphatase#PC00181 HUMAN|HGNC=17841|UniProtKB=Q5VZ52 Q5VZ52 MORN5 PTHR46437:SF1 MORN REPEAT-CONTAINING PROTEIN 5 MORN REPEAT-CONTAINING PROTEIN 5 HUMAN|HGNC=4567|UniProtKB=Q14451 Q14451 GRB7 PTHR11243:SF25 GROWTH FACTOR RECEPTOR-BOUND PROTEIN GROWTH FACTOR RECEPTOR-BOUND PROTEIN 7 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 cellular response to insulin stimulus#GO:0032869;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;response to peptide hormone#GO:0043434;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;cellular response to nitrogen compound#GO:1901699;negative regulation of response to stimulus#GO:0048585;intracellular signal transduction#GO:0035556;response to nitrogen compound#GO:1901698;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cellular response to peptide hormone stimulus#GO:0071375;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;response to insulin#GO:0032868;cell surface receptor signaling pathway#GO:0007166;negative regulation of signal transduction#GO:0009968;response to chemical#GO:0042221;cellular process#GO:0009987;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;response to hormone#GO:0009725;negative regulation of cell communication#GO:0010648;regulation of signaling#GO:0023051;response to oxygen-containing compound#GO:1901700;insulin receptor signaling pathway#GO:0008286;negative regulation of signaling#GO:0023057;cellular response to chemical stimulus#GO:0070887;signaling#GO:0023052;cellular response to hormone stimulus#GO:0032870;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;response to endogenous stimulus#GO:0009719 scaffold/adaptor protein#PC00226 Angiogenesis#P00005>Grb7#P00228 HUMAN|HGNC=7612|UniProtKB=P15173 P15173 MYOG PTHR11534:SF5 MYOGENIC FACTOR MYOGENIN DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of cell development#GO:0060284;skeletal muscle tissue development#GO:0007519;positive regulation of cellular process#GO:0048522;positive regulation of DNA-templated transcription#GO:0045893;tissue development#GO:0009888;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;regulation of cell differentiation#GO:0045595;positive regulation of developmental process#GO:0051094;developmental process#GO:0032502;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;muscle structure development#GO:0061061;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;regulation of developmental process#GO:0050793;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;muscle tissue development#GO:0060537;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of cell development#GO:0010720;regulation of multicellular organismal process#GO:0051239;muscle organ development#GO:0007517;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of cell differentiation#GO:0045597;striated muscle tissue development#GO:0014706;animal organ development#GO:0048513;positive regulation of multicellular organismal process#GO:0051240;regulation of biological process#GO:0050789;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;skeletal muscle organ development#GO:0060538;animal gross anatomical part developmental process#GO:0160108;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893 intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=9369|UniProtKB=P49642 P49642 PRIM1 PTHR10536:SF0 DNA PRIMASE SMALL SUBUNIT DNA PRIMASE SMALL SUBUNIT transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on RNA#GO:0140098 DNA replication#GO:0006260;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;biosynthetic process#GO:0009058;RNA biosynthetic process#GO:0032774;nucleobase-containing compound metabolic process#GO:0006139;nucleic acid biosynthetic process#GO:0141187;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;DNA metabolic process#GO:0006259;DNA-templated DNA replication#GO:0006261;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070 transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;nuclear replication fork#GO:0043596;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;chromosome#GO:0005694;replication fork#GO:0005657;replisome#GO:0030894;nuclear DNA-directed RNA polymerase complex#GO:0055029;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;protein-DNA complex#GO:0032993;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;DNA polymerase complex#GO:0042575;transferase complex#GO:1990234;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228 primase#PC00189 DNA replication#P00017>Primase#P00528 HUMAN|HGNC=4066|UniProtKB=Q13480 Q13480 GAB1 PTHR45960:SF5 GRB2-ASSOCIATED-BINDING PROTEIN GRB2-ASSOCIATED-BINDING PROTEIN 1 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;signaling adaptor activity#GO:0035591 biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 scaffold/adaptor protein#PC00226 PDGF signaling pathway#P00047>Grb2#P01148;EGF receptor signaling pathway#P00018>Gab#P00563 HUMAN|HGNC=5004|UniProtKB=O15347 O15347 HMGB3 PTHR48112:SF43 HIGH MOBILITY GROUP PROTEIN DSP1 HIGH MOBILITY GROUP PROTEIN B3 cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;chromatin organization#GO:0006325;chromatin remodeling#GO:0006338 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;HMG box transcription factor#PC00024 HUMAN|HGNC=25095|UniProtKB=Q66K64 Q66K64 DCAF15 PTHR28541:SF1 DDB1- AND CUL4-ASSOCIATED FACTOR 15 DDB1- AND CUL4-ASSOCIATED FACTOR 15 protein modification by small protein conjugation#GO:0032446;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538 catalytic complex#GO:1902494;transferase complex#GO:1990234;Cul4-RING E3 ubiquitin ligase complex#GO:0080008;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991 HUMAN|HGNC=25634|UniProtKB=Q9HA92 Q9HA92 RSAD1 PTHR13932:SF5 COPROPORPHYRINIGEN III OXIDASE RADICAL S-ADENOSYL METHIONINE DOMAIN-CONTAINING PROTEIN 1, MITOCHONDRIAL binding#GO:0005488;small molecule binding#GO:0036094;iron-sulfur cluster binding#GO:0051536 tetrapyrrole biosynthetic process#GO:0033014;porphyrin-containing compound biosynthetic process#GO:0006779;biosynthetic process#GO:0009058;tetrapyrrole metabolic process#GO:0033013;metabolic process#GO:0008152;porphyrin-containing compound metabolic process#GO:0006778;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 oxidase#PC00175 Heme biosynthesis#P02746>Coproporphyrinogen oxidase (oxygen independent)#P02970 HUMAN|HGNC=37200|UniProtKB=A6NM45 A6NM45 CLDN24 PTHR12002:SF84 CLAUDIN CLAUDIN-24 cell-cell junction assembly#GO:0007043;cell-cell junction organization#GO:0045216;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;cell junction assembly#GO:0034329;cell junction organization#GO:0034330;cellular component assembly#GO:0022607 cellular anatomical structure#GO:0110165;bicellular tight junction#GO:0005923;plasma membrane#GO:0005886;membrane#GO:0016020;cell-cell junction#GO:0005911;cell periphery#GO:0071944;tight junction#GO:0070160;cell junction#GO:0030054;anchoring junction#GO:0070161;apical junction complex#GO:0043296 cell junction protein#PC00070;tight junction#PC00214 HUMAN|HGNC=7717|UniProtKB=P19404 P19404 NDUFV2 PTHR10371:SF3 NADH DEHYDROGENASE UBIQUINONE FLAVOPROTEIN 2, MITOCHONDRIAL NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 2, MITOCHONDRIAL oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on NAD(P)H#GO:0016651;catalytic activity#GO:0003824;NADH dehydrogenase activity#GO:0003954 mitochondrial electron transport, NADH to ubiquinone#GO:0006120;generation of precursor metabolites and energy#GO:0006091;aerobic electron transport chain#GO:0019646;metabolic process#GO:0008152;aerobic respiration#GO:0009060;energy derivation by oxidation of organic compounds#GO:0015980;cellular respiration#GO:0045333;oxidative phosphorylation#GO:0006119;ATP synthesis coupled electron transport#GO:0042773;cellular process#GO:0009987;respiratory electron transport chain#GO:0022904;mitochondrial ATP synthesis coupled electron transport#GO:0042775;electron transport chain#GO:0022900 respiratory chain complex#GO:0098803;membrane#GO:0016020;oxidoreductase complex#GO:1990204;membrane protein complex#GO:0098796;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;respiratory chain complex I#GO:0045271;catalytic complex#GO:1902494;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495 dehydrogenase#PC00092;oxidoreductase#PC00176 Parkinson disease#P00049>Complex I#P01237 HUMAN|HGNC=24594|UniProtKB=Q9BTE1 Q9BTE1 DCTN5 PTHR46126:SF2 DYNACTIN SUBUNIT 5 DYNACTIN SUBUNIT 5 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;actin cytoskeleton#GO:0015629;microtubule cytoskeleton#GO:0015630;cellular anatomical structure#GO:0110165;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232 microtubule binding motor protein#PC00156 HUMAN|HGNC=2160|UniProtKB=P34972 P34972 CNR2 PTHR22750:SF10 G-PROTEIN COUPLED RECEPTOR CANNABINOID RECEPTOR 2 molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021 HUMAN|HGNC=20958|UniProtKB=Q9P2C4 Q9P2C4 TMEM181 PTHR31918:SF2 TRANSMEMBRANE PROTEIN 181 TRANSMEMBRANE PROTEIN 181 regulation of protein transport#GO:0051223;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of cell communication#GO:0010646;regulation of protein secretion#GO:0050708;regulation of biological process#GO:0050789;positive regulation of signaling#GO:0023056;regulation of secretion#GO:0051046;regulation of secretion by cell#GO:1903530;regulation of establishment of protein localization#GO:0070201;regulation of protein localization#GO:0032880;regulation of signaling#GO:0023051;positive regulation of secretion#GO:0051047;biological regulation#GO:0065007;positive regulation of biological process#GO:0048518;positive regulation of secretion by cell#GO:1903532;positive regulation of transport#GO:0051050;positive regulation of cellular process#GO:0048522;positive regulation of protein secretion#GO:0050714;regulation of transport#GO:0051049;regulation of localization#GO:0032879 membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=8021|UniProtKB=P21589 P21589 NT5E PTHR11575:SF50 5'-NUCLEOTIDASE-RELATED 5'-NUCLEOTIDASE phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;nucleotidase activity#GO:0008252;5'-nucleotidase activity#GO:0008253;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578 purine-containing compound catabolic process#GO:0072523;nucleobase-containing small molecule metabolic process#GO:0055086;purine nucleoside monophosphate metabolic process#GO:0009126;nucleotide catabolic process#GO:0009166;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;nucleobase-containing compound metabolic process#GO:0006139;nucleobase-containing compound catabolic process#GO:0034655;organophosphate metabolic process#GO:0019637;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;ribonucleotide catabolic process#GO:0009261;carbohydrate derivative metabolic process#GO:1901135;nucleotide metabolic process#GO:0009117;organophosphate catabolic process#GO:0046434;ribonucleotide metabolic process#GO:0009259;purine nucleotide catabolic process#GO:0006195;nucleoside phosphate catabolic process#GO:1901292;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;carbohydrate derivative catabolic process#GO:1901136;nucleoside monophosphate metabolic process#GO:0009123;purine ribonucleoside monophosphate metabolic process#GO:0009167;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521;purine ribonucleotide catabolic process#GO:0009154;purine nucleotide metabolic process#GO:0006163 membrane#GO:0016020;extracellular region#GO:0005576;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 hydrolase#PC00121;phosphodiesterase#PC00185;metabolite interconversion enzyme#PC00262 Pyrimidine Metabolism#P02771>5'-Nucleotidase#P03131;Purine metabolism#P02769>5'-Nucleotidase#P03119 HUMAN|HGNC=16877|UniProtKB=O95140 O95140 MFN2 PTHR10465:SF1 TRANSMEMBRANE GTPASE FZO1 MITOFUSIN-2 ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462 cellular component organization or biogenesis#GO:0071840;localization#GO:0051179;mitochondrion localization#GO:0051646;organelle localization#GO:0051640;organelle fusion#GO:0048284;mitochondrion organization#GO:0007005;cellular component organization#GO:0016043;organelle organization#GO:0006996;mitochondrial fusion#GO:0008053;cellular process#GO:0009987 cytoplasm#GO:0005737;organelle outer membrane#GO:0031968;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;membrane#GO:0016020;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;mitochondrial outer membrane#GO:0005741;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;organelle envelope#GO:0031967;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;outer membrane#GO:0019867 HUMAN|HGNC=23689|UniProtKB=Q5T848 Q5T848 GPR158 PTHR32546:SF11 G-PROTEIN COUPLED RECEPTOR 158-RELATED METABOTROPIC GLYCINE RECEPTOR transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=14976|UniProtKB=Q9UMY4 Q9UMY4 SNX12 PTHR45963:SF3 RE52028P SORTING NEXIN-12 binding#GO:0005488;phospholipid binding#GO:0005543;lipid binding#GO:0008289;phosphatidylinositol-3-phosphate binding#GO:0032266;phosphatidylinositol phosphate binding#GO:1901981 retrograde transport, endosome to Golgi#GO:0042147;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;endocytic recycling#GO:0032456;vesicle-mediated transport#GO:0016192;cytosolic transport#GO:0016482;intracellular transport#GO:0046907;localization within membrane#GO:0051668;transport#GO:0006810;Golgi vesicle transport#GO:0048193;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;vesicle-mediated transport to the plasma membrane#GO:0098876;endosomal transport#GO:0016197 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;membrane-bounded organelle#GO:0043227;early endosome#GO:0005769;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome membrane#GO:0010008;endosome#GO:0005768;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;vesicle membrane#GO:0012506;membrane#GO:0016020;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;early endosome membrane#GO:0031901 HUMAN|HGNC=25538|UniProtKB=Q6PI48 Q6PI48 DARS2 PTHR22594:SF56 ASPARTYL/LYSYL-TRNA SYNTHETASE ASPARTATE--TRNA LIGASE, MITOCHONDRIAL ligase activity#GO:0016874;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098 gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;tRNA aminoacylation#GO:0043039;tRNA aminoacylation for protein translation#GO:0006418;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;amino acid activation#GO:0043038;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;protein biosynthetic process#GO:0160307;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;protein metabolic process#GO:0019538;RNA metabolic process#GO:0016070;translation#GO:0006412 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 translational protein#PC00263;aminoacyl-tRNA synthetase#PC00047 HUMAN|HGNC=21305|UniProtKB=Q9Y597 Q9Y597 KCTD3 PTHR15859:SF2 SETA BINDING PROTEIN 1 BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD3 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HUMAN|HGNC=1059|UniProtKB=Q13867 Q13867 BLMH PTHR10363:SF2 BLEOMYCIN HYDROLASE BLEOMYCIN HYDROLASE peptidase activity#GO:0008233;exopeptidase activity#GO:0008238;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;aminopeptidase activity#GO:0004177 oxoacid metabolic process#GO:0043436;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;response to stimulus#GO:0050896;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;response to toxic substance#GO:0009636;small molecule catabolic process#GO:0044282;metabolic process#GO:0008152;sulfur compound catabolic process#GO:0044273;sulfur compound metabolic process#GO:0006790;carboxylic acid catabolic process#GO:0046395;homocysteine metabolic process#GO:0050667;cellular process#GO:0009987;response to chemical#GO:0042221;amino acid metabolic process#GO:0006520 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 cysteine protease#PC00081 HUMAN|HGNC=17642|UniProtKB=Q96SD1 Q96SD1 DCLRE1C PTHR23240:SF37 DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED PROTEIN ARTEMIS catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;DNA nuclease activity#GO:0004536;hydrolase activity, acting on ester bonds#GO:0016788;DNA exonuclease activity#GO:0004529;damaged DNA binding#GO:0003684;catalytic activity, acting on DNA#GO:0140097;nucleic acid binding#GO:0003676;binding#GO:0005488;exonuclease activity#GO:0004527;DNA binding#GO:0003677;hydrolase activity#GO:0016787;5'-3' exonuclease activity#GO:0008409;DNA exonuclease activity, producing 5'-phosphomonoesters#GO:0016895;nuclease activity#GO:0004518 nucleobase-containing compound metabolic process#GO:0006139;interstrand cross-link repair#GO:0036297;response to stress#GO:0006950;organelle organization#GO:0006996;cellular process#GO:0009987;double-strand break repair via nonhomologous end joining#GO:0006303;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;double-strand break repair#GO:0006302;telomere maintenance#GO:0000723;chromosome organization#GO:0051276;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA damage response#GO:0006974;response to stimulus#GO:0050896;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;cellular response to stimulus#GO:0051716;telomere organization#GO:0032200;cellular response to stress#GO:0033554 nucleus#GO:0005634;DNA repair complex#GO:1990391;nonhomologous end joining complex#GO:0070419;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 DNA metabolism protein#PC00009 HUMAN|HGNC=44405|UniProtKB=F8WBI6 F8WBI6 GOLGA8N PTHR10881:SF62 GOLGIN SUBFAMILY A MEMBER-RELATED GOLGIN SUBFAMILY A CONSERVED DOMAIN-CONTAINING PROTEIN-RELATED organelle organization#GO:0006996;cellular component organization#GO:0016043;Golgi organization#GO:0007030;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;endomembrane system organization#GO:0010256 Golgi stack#GO:0005795;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;endomembrane system#GO:0012505;Golgi cisterna#GO:0031985;cytoplasm#GO:0005737;Golgi cis cisterna#GO:0000137;Golgi apparatus#GO:0005794;organelle membrane#GO:0031090;cis-Golgi network#GO:0005801 membrane traffic protein#PC00150 HUMAN|HGNC=17094|UniProtKB=Q96EH5 Q96EH5 RPL39L PTHR19970:SF22 RIBOSOMAL PROTEIN L39E RIBOSOMAL PROTEIN EL39-LIKE 2 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 biosynthetic process#GO:0009058;gene expression#GO:0010467;male gamete generation#GO:0048232;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;developmental process#GO:0032502;spermatogenesis#GO:0007283;metabolic process#GO:0008152;reproductive process#GO:0022414;protein biosynthetic process#GO:0160307;gamete generation#GO:0007276;cytoplasmic translation#GO:0002181;primary metabolic process#GO:0044238;developmental process involved in reproduction#GO:0003006;multicellular organismal reproductive process#GO:0048609;protein metabolic process#GO:0019538;translation#GO:0006412;sexual reproduction#GO:0019953 cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904 ribosomal protein#PC00202 HUMAN|HGNC=3608|UniProtKB=P24071 P24071 FCAR PTHR11738:SF4 MHC CLASS I NK CELL RECEPTOR IMMUNOGLOBULIN ALPHA FC RECEPTOR transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;immune receptor activity#GO:0140375;signaling receptor activity#GO:0038023 regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166;regulation of immune response#GO:0050776;cell communication#GO:0007154;immune response-regulating signaling pathway#GO:0002764;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;response to stimulus#GO:0050896;immune response-regulating cell surface receptor signaling pathway#GO:0002768;signaling#GO:0023052;biological regulation#GO:0065007 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=29589|UniProtKB=Q6PEX7 Q6PEX7 TEX38 PTHR37362:SF1 TESTIS-EXPRESSED PROTEIN 38 TESTIS-EXPRESSED PROTEIN 38 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HUMAN|HGNC=33763|UniProtKB=Q6UX34 Q6UX34 SNORC PTHR28453:SF1 PROTEIN SNORC PROTEIN SNORC cell periphery#GO:0071944;cellular anatomical structure#GO:0110165 HUMAN|HGNC=14885|UniProtKB=Q8WW22 Q8WW22 DNAJA4 PTHR43888:SF9 DNAJ-LIKE-2, ISOFORM A-RELATED DNAJ HOMOLOG SUBFAMILY A MEMBER 4 molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;protein binding#GO:0005515;ATPase activator activity#GO:0001671;binding#GO:0005488;protein-folding chaperone binding#GO:0051087 protein metabolic process#GO:0019538;protein refolding#GO:0042026;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;protein folding#GO:0006457;primary metabolic process#GO:0044238;response to abiotic stimulus#GO:0009628;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;gene expression#GO:0010467;protein maturation#GO:0051604;response to temperature stimulus#GO:0009266;biosynthetic process#GO:0009058;response to stress#GO:0006950;cellular response to heat#GO:0034605;response to heat#GO:0009408;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 chaperone#PC00072 HUMAN|HGNC=1854|UniProtKB=Q03188 Q03188 CENPC PTHR16684:SF12 CENTROMERE PROTEIN C CENTROMERE PROTEIN C nucleic acid binding#GO:0003676;binding#GO:0005488;double-stranded DNA binding#GO:0003690;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA binding#GO:0003677 metaphase chromosome alignment#GO:0051310;chromosome segregation#GO:0007059;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;chromosome organization#GO:0051276;mitotic cell cycle process#GO:1903047;attachment of spindle microtubules to kinetochore#GO:0008608;cellular component biogenesis#GO:0044085;mitotic sister chromatid segregation#GO:0000070;organelle organization#GO:0006996;cellular process#GO:0009987;cellular component assembly#GO:0022607;chromosome localization#GO:0050000;nuclear division#GO:0000280;organelle localization#GO:0051640;organelle assembly#GO:0070925;kinetochore assembly#GO:0051382;attachment of mitotic spindle microtubules to kinetochore#GO:0051315;organelle fission#GO:0048285;kinetochore organization#GO:0051383;localization#GO:0051179;cellular component organization#GO:0016043;sister chromatid segregation#GO:0000819;nuclear chromosome segregation#GO:0098813;membraneless organelle assembly#GO:0140694;cell cycle#GO:0007049;cell cycle process#GO:0022402;mitotic nuclear division#GO:0140014;mitotic metaphase chromosome alignment#GO:0007080;protein-containing complex assembly#GO:0065003;mitotic cell cycle#GO:0000278 condensed chromosome, centromeric region#GO:0000779;chromosome#GO:0005694;kinetochore#GO:0000776;cellular anatomical structure#GO:0110165;organelle#GO:0043226;supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232;condensed chromosome#GO:0000793;chromosome, centromeric region#GO:0000775;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687 centromere DNA-binding protein#PC00071 HUMAN|HGNC=6882|UniProtKB=Q9UQF2 Q9UQF2 MAPK8IP1 PTHR47437:SF3 JNK-INTERACTING PROTEIN 1-LIKE PROTEIN C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 1 protein complex scaffold activity#GO:0140378;molecular adaptor activity#GO:0060090;structural molecule activity#GO:0005198;MAP kinase scaffold activity#GO:0005078;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;protein-macromolecule adaptor activity#GO:0030674;kinase binding#GO:0019900;binding#GO:0005488;protein binding#GO:0005515;signaling adaptor activity#GO:0035591 MAPK cascade#GO:0000165;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;JNK cascade#GO:0007254;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=3538|UniProtKB=P55085 P55085 F2RL1 PTHR24232:SF21 G-PROTEIN COUPLED RECEPTOR PROTEINASE-ACTIVATED RECEPTOR 2 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089 G protein-coupled receptor signaling pathway#GO:0007186;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;cell communication#GO:0007154;positive regulation of signaling#GO:0023056;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;positive regulation of cell communication#GO:0010647;regulation of Rho protein signal transduction#GO:0035023;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of cell communication#GO:0010646;positive regulation of ERK1 and ERK2 cascade#GO:0070374;regulation of MAPK cascade#GO:0043408;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;positive regulation of MAPK cascade#GO:0043410;regulation of small GTPase mediated signal transduction#GO:0051056;signal transduction#GO:0007165;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of response to stimulus#GO:0048584;regulation of ERK1 and ERK2 cascade#GO:0070372;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=3420|UniProtKB=Q12929 Q12929 EPS8 PTHR12287:SF21 EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8-RELATED PROTEIN EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE 8 protein binding#GO:0005515;binding#GO:0005488;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092 regulation of small GTPase mediated signal transduction#GO:0051056;regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of response to stimulus#GO:0048583;regulation of cell projection organization#GO:0031344;intracellular signaling cassette#GO:0141124;regulation of signal transduction#GO:0009966;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;positive regulation of cellular component biogenesis#GO:0044089;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of cellular process#GO:0048522;intracellular signal transduction#GO:0035556;regulation of cell projection assembly#GO:0060491;Rho protein signal transduction#GO:0007266;cell communication#GO:0007154;regulation of signaling#GO:0023051;positive regulation of cell projection organization#GO:0031346;positive regulation of cellular component organization#GO:0051130;regulation of intracellular signal transduction#GO:1902531;regulation of cell communication#GO:0010646;regulation of cellular component biogenesis#GO:0044087;signaling#GO:0023052;regulation of Rho protein signal transduction#GO:0035023;regulation of cellular process#GO:0050794;regulation of plasma membrane bounded cell projection assembly#GO:0120032;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789 ruffle#GO:0001726;cell projection membrane#GO:0031253;ruffle membrane#GO:0032587;leading edge membrane#GO:0031256;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;cell projection#GO:0042995;membrane#GO:0016020;cell leading edge#GO:0031252;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HUMAN|HGNC=13195|UniProtKB=O95229 O95229 ZWINT PTHR31504:SF1 ZW10 INTERACTOR ZWINT OUTER KINETOCHORE KNL1 COMPLEX SUBUNIT ZWINT negative regulation of chromosome segregation#GO:0051985;negative regulation of metaphase/anaphase transition of cell cycle#GO:1902100;negative regulation of mitotic sister chromatid segregation#GO:0033048;cellular component organization or biogenesis#GO:0071840;negative regulation of sister chromatid segregation#GO:0033046;organelle organization#GO:0006996;cellular process#GO:0009987;signal transduction#GO:0007165;establishment of localization in cell#GO:0051649;regulation of chromosome separation#GO:1905818;negative regulation of mitotic cell cycle phase transition#GO:1901991;nuclear division#GO:0000280;cellular localization#GO:0051641;nuclear chromosome segregation#GO:0098813;sister chromatid segregation#GO:0000819;negative regulation of cell cycle phase transition#GO:1901988;negative regulation of biological process#GO:0048519;cell cycle process#GO:0022402;mitotic nuclear division#GO:0140014;regulation of organelle organization#GO:0033043;negative regulation of mitotic nuclear division#GO:0045839;regulation of biological process#GO:0050789;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;regulation of cell cycle#GO:0051726;negative regulation of cellular process#GO:0048523;chromosome organization#GO:0051276;negative regulation of chromosome separation#GO:1905819;mitotic cell cycle process#GO:1903047;regulation of mitotic metaphase/anaphase transition#GO:0030071;biological regulation#GO:0065007;regulation of mitotic sister chromatid segregation#GO:0033047;negative regulation of organelle organization#GO:0010639;cell cycle#GO:0007049;regulation of cell cycle phase transition#GO:1901987;cellular response to stimulus#GO:0051716;negative regulation of mitotic metaphase/anaphase transition#GO:0045841;regulation of cellular process#GO:0050794;chromosome segregation#GO:0007059;regulation of chromosome segregation#GO:0051983;negative regulation of cell cycle#GO:0045786;mitotic spindle assembly checkpoint signaling#GO:0007094;cell cycle checkpoint signaling#GO:0000075;regulation of cell cycle process#GO:0010564;negative regulation of mitotic sister chromatid separation#GO:2000816;regulation of mitotic cell cycle phase transition#GO:1901990;negative regulation of mitotic cell cycle#GO:0045930;cellular component organization#GO:0016043;regulation of sister chromatid segregation#GO:0033045;signaling#GO:0023052;regulation of chromosome organization#GO:0033044;negative regulation of cell cycle process#GO:0010948;regulation of mitotic sister chromatid separation#GO:0010965;establishment of localization#GO:0051234;regulation of mitotic nuclear division#GO:0007088;mitotic sister chromatid segregation#GO:0000070;regulation of mitotic cell cycle#GO:0007346;regulation of nuclear division#GO:0051783;negative regulation of nuclear division#GO:0051784;negative regulation of chromosome organization#GO:2001251;organelle fission#GO:0048285;cell communication#GO:0007154;localization#GO:0051179;intracellular signal transduction#GO:0035556;negative regulation of cellular component organization#GO:0051129;mitotic cell cycle checkpoint signaling#GO:0007093;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;mitotic cell cycle#GO:0000278 chromosome, centromeric region#GO:0000775;condensed chromosome#GO:0000793;membraneless organelle#GO:0043228;nucleus#GO:0005634;neuron projection#GO:0043005;membrane-enclosed lumen#GO:0031974;condensed chromosome, centromeric region#GO:0000779;cytosol#GO:0005829;cytoplasm#GO:0005737;nuclear body#GO:0016604;intracellular membraneless organelle#GO:0043232;somatodendritic compartment#GO:0036477;supramolecular complex#GO:0099080;intracellular organelle#GO:0043229;dendritic tree#GO:0097447;dendrite#GO:0030425;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687;membrane-bounded organelle#GO:0043227;kinetochore#GO:0000776;organelle lumen#GO:0043233;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226 HUMAN|HGNC=40050|UniProtKB=D6RGH6 D6RGH6 MCIDAS PTHR13372:SF3 GEMININ MULTICILIN transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 organelle assembly#GO:0070925;cilium organization#GO:0044782;regulation of DNA replication#GO:0006275;regulation of DNA metabolic process#GO:0051052;regulation of DNA-templated DNA replication#GO:0090329;regulation of biological process#GO:0050789;cilium assembly#GO:0060271;cellular component organization#GO:0016043;regulation of cellular process#GO:0050794;cell projection organization#GO:0030030;regulation of macromolecule metabolic process#GO:0060255;plasma membrane bounded cell projection assembly#GO:0120031;motile cilium assembly#GO:0044458;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cell projection assembly#GO:0030031;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;regulation of DNA-templated DNA replication initiation#GO:0030174;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;cellular component assembly#GO:0022607;regulation of nucleobase-containing compound metabolic process#GO:0019219 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=25949|UniProtKB=Q9NXT0 Q9NXT0 ZNF586 PTHR24377:SF708 IP01015P-RELATED ZINC FINGER PROTEIN 586 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=17521|UniProtKB=Q96PM9 Q96PM9 ZNF385A PTHR23067:SF13 DOUBLE-STRANDED RNA-BINDING ZINC FINGER PROTEIN ZINC FINGER PROTEIN 385A intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=14408|UniProtKB=Q9NQF3 Q9NQF3 SERHL PTHR43329:SF4 EPOXIDE HYDROLASE SERINE HYDROLASE-LIKE PROTEIN-RELATED hydrolase activity#GO:0016787;catalytic activity#GO:0003824 hydrolase#PC00121 HUMAN|HGNC=11041|UniProtKB=Q9Y289 Q9Y289 SLC5A6 PTHR42985:SF2 SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER SODIUM-DEPENDENT MULTIVITAMIN TRANSPORTER symporter activity#GO:0015293;solute:sodium symporter activity#GO:0015370;monoatomic cation transmembrane transporter activity#GO:0008324;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;solute:monoatomic cation symporter activity#GO:0015294;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081 monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transport#GO:0006811;monocarboxylic acid transport#GO:0015718;transport#GO:0006810;organic acid transport#GO:0015849;carboxylic acid transport#GO:0046942;vitamin transport#GO:0051180;metal ion transport#GO:0030001;carboxylic acid transmembrane transport#GO:1905039;nitrogen compound transport#GO:0071705;cellular process#GO:0009987;sodium ion transport#GO:0006814 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 secondary carrier transporter#PC00258;transporter#PC00227 HUMAN|HGNC=6556|UniProtKB=O95202 O95202 LETM1 PTHR14009:SF8 LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN MITOCHONDRIAL PROTON_CALCIUM EXCHANGER PROTEIN monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;proton transmembrane transporter activity#GO:0015078;antiporter activity#GO:0015297;secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;metal cation:proton antiporter activity#GO:0051139;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804 organelle organization#GO:0006996;mitochondrial calcium ion transmembrane transport#GO:0006851;cellular process#GO:0009987;mitochondrion organization#GO:0007005;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;calcium ion transport#GO:0006816;calcium ion transmembrane transport#GO:0070588;cellular component organization#GO:0016043;metal ion transport#GO:0030001;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 transporter#PC00227;secondary carrier transporter#PC00258 HUMAN|HGNC=20725|UniProtKB=Q9BUY5 Q9BUY5 ZNF426 PTHR24377:SF799 IP01015P-RELATED ZINC FINGER PROTEIN 426 RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=25648|UniProtKB=Q8N5J2 Q8N5J2 MINDY1 PTHR18063:SF7 NF-E2 INDUCIBLE PROTEIN UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MINDY-1 catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;exopeptidase activity#GO:0008238;hydrolase activity#GO:0016787;carboxypeptidase activity#GO:0004180;deubiquitinase activity#GO:0101005 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634 HUMAN|HGNC=23612|UniProtKB=Q6ZQN7 Q6ZQN7 SLCO4C1 PTHR11388:SF103 ORGANIC ANION TRANSPORTER SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 4C1 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;secondary active transmembrane transporter activity#GO:0015291;active transmembrane transporter activity#GO:0022804 establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;transport#GO:0006810;cellular process#GO:0009987 basal plasma membrane#GO:0009925;cell periphery#GO:0071944;basolateral plasma membrane#GO:0016323;basal part of cell#GO:0045178;membrane#GO:0016020;plasma membrane#GO:0005886;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165 transporter#PC00227 HUMAN|HGNC=23512|UniProtKB=Q7Z5L2 Q7Z5L2 R3HCC1L PTHR21678:SF7 GROWTH INHIBITION AND DIFFERENTIATION RELATED PROTEIN 88 COILED-COIL DOMAIN-CONTAINING PROTEIN R3HCC1L HUMAN|HGNC=28972|UniProtKB=Q8IXZ2 Q8IXZ2 ZC3H3 PTHR46156:SF1 CCCH ZINGC FINGER ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 3 HUMAN|HGNC=17055|UniProtKB=Q9HAP2 Q9HAP2 MLXIP PTHR15741:SF23 BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR MLX-INTERACTING PROTEIN cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218 HUMAN|HGNC=15885|UniProtKB=Q9H7V2 Q9H7V2 SYNDIG1 PTHR14768:SF3 UPF0338 PROTEIN SYNAPSE DIFFERENTIATION-INDUCING GENE PROTEIN 1 regulation of biological process#GO:0050789;positive regulation of multicellular organismal process#GO:0051240;regulation of multicellular organismal development#GO:2000026;positive regulation of nervous system development#GO:0051962;regulation of cellular component organization#GO:0051128;regulation of cellular component biogenesis#GO:0044087;positive regulation of cellular component organization#GO:0051130;regulation of synapse organization#GO:0050807;cellular localization#GO:0051641;regulation of biological quality#GO:0065008;positive regulation of biological process#GO:0048518;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;synaptic vesicle localization#GO:0097479;positive regulation of cellular component biogenesis#GO:0044089;regulation of multicellular organismal process#GO:0051239;vesicle-mediated transport in synapse#GO:0099003;regulation of cellular process#GO:0050794;regulation of developmental process#GO:0050793;organelle localization#GO:0051640;regulation of cell junction assembly#GO:1901888;localization#GO:0051179;regulation of synapse structure or activity#GO:0050803;regulation of nervous system development#GO:0051960;positive regulation of cellular process#GO:0048522;vesicle localization#GO:0051648;regulation of synapse assembly#GO:0051963;biological regulation#GO:0065007;positive regulation of developmental process#GO:0051094;synaptic vesicle cycle#GO:0099504;transport#GO:0006810;establishment of localization#GO:0051234;positive regulation of synapse assembly#GO:0051965 synaptic membrane#GO:0097060;cell junction#GO:0030054;bounding membrane of organelle#GO:0098588;secretory vesicle#GO:0099503;presynapse#GO:0098793;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;postsynaptic specialization membrane#GO:0099634;postsynaptic membrane#GO:0045211;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;postsynapse#GO:0098794;intracellular vesicle#GO:0097708;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;organelle membrane#GO:0031090;membrane#GO:0016020;vesicle membrane#GO:0012506;cell periphery#GO:0071944;endomembrane system#GO:0012505;transport vesicle membrane#GO:0030658;neuron to neuron synapse#GO:0098984;plasma membrane region#GO:0098590;transport vesicle#GO:0030133;postsynaptic specialization#GO:0099572;plasma membrane#GO:0005886;postsynaptic density#GO:0014069;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;postsynaptic density membrane#GO:0098839;membrane-bounded organelle#GO:0043227;synaptic vesicle#GO:0008021;synaptic vesicle membrane#GO:0030672;vesicle#GO:0031982;asymmetric synapse#GO:0032279;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=28422|UniProtKB=Q8NCE0 Q8NCE0 TSEN2 PTHR21227:SF0 TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2 TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2 nuclease activity#GO:0004518;catalytic activity, acting on a tRNA#GO:0140101;lyase activity#GO:0016829;endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;catalytic activity, acting on RNA#GO:0140098;RNA endonuclease activity#GO:0004521;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;tRNA splicing, via endonucleolytic cleavage and ligation#GO:0006388;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endonuclease complex#GO:1905348;endoribonuclease complex#GO:1902555;intracellular organelle#GO:0043229;catalytic complex#GO:1902494 endodeoxyribonuclease#PC00093;DNA metabolism protein#PC00009 HUMAN|HGNC=27046|UniProtKB=Q86YD5 Q86YD5 LDLRAD3 PTHR24270:SF24 LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED LOW-DENSITY LIPOPROTEIN RECEPTOR CLASS A DOMAIN-CONTAINING PROTEIN 3 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 apolipoprotein#PC00052;transfer/carrier protein#PC00219 HUMAN|HGNC=4963|UniProtKB=P30511 P30511 HLA-F PTHR16675:SF187 MHC CLASS I-RELATED HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, ALPHA CHAIN F protein binding#GO:0005515;peptide binding#GO:0042277;antigen binding#GO:0003823;binding#GO:0005488;signaling receptor binding#GO:0005102 positive regulation of cellular process#GO:0048522;immune response#GO:0006955;positive regulation of biological process#GO:0048518;positive regulation of immune system process#GO:0002684;biological regulation#GO:0065007;positive regulation of immune effector process#GO:0002699;positive regulation of response to stimulus#GO:0048584;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;positive regulation of leukocyte mediated immunity#GO:0002705;regulation of biological process#GO:0050789;regulation of leukocyte mediated immunity#GO:0002703;positive regulation of adaptive immune response#GO:0002821;response to stimulus#GO:0050896;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of immune response#GO:0050776;regulation of cell killing#GO:0031341;regulation of lymphocyte mediated immunity#GO:0002706;immune system process#GO:0002376;regulation of leukocyte mediated cytotoxicity#GO:0001910;positive regulation of lymphocyte mediated immunity#GO:0002708;antigen processing and presentation#GO:0019882;regulation of immune effector process#GO:0002697 side of membrane#GO:0098552;extracellular region#GO:0005576;external side of plasma membrane#GO:0009897;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 defense/immunity protein#PC00090;major histocompatibility complex protein#PC00149 HUMAN|HGNC=14278|UniProtKB=Q9BYD1 Q9BYD1 MRPL13 PTHR11545:SF45 RIBOSOMAL PROTEIN L13 LARGE RIBOSOMAL SUBUNIT PROTEIN UL13M structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;negative regulation of macromolecule metabolic process#GO:0010605;regulation of protein metabolic process#GO:0051246;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;negative regulation of translation#GO:0017148;negative regulation of protein metabolic process#GO:0051248;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;ribosome#GO:0005840;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;mitochondrial ribosome#GO:0005761;intracellular anatomical structure#GO:0005622;organellar ribosome#GO:0000313;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;large ribosomal subunit#GO:0015934;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;membrane-enclosed lumen#GO:0031974;membraneless organelle#GO:0043228;mitochondrial large ribosomal subunit#GO:0005762 translational protein#PC00263;ribosomal protein#PC00202 HUMAN|HGNC=12762|UniProtKB=O76024 O76024 WFS1 PTHR13098:SF3 WOLFRAMIN WOLFRAMIN signaling#GO:0023052;response to topologically incorrect protein#GO:0035966;homeostatic process#GO:0042592;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;intracellular signal transduction#GO:0035556;response to unfolded protein#GO:0006986;cell communication#GO:0007154;cellular response to stress#GO:0033554;inorganic ion homeostasis#GO:0098771;cellular response to topologically incorrect protein#GO:0035967;cellular response to unfolded protein#GO:0034620;calcium ion homeostasis#GO:0055074;response to endoplasmic reticulum stress#GO:0034976;biological regulation#GO:0065007;signal transduction#GO:0007165;cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801;endoplasmic reticulum unfolded protein response#GO:0030968;response to stress#GO:0006950;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080 organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020 HUMAN|HGNC=29021|UniProtKB=O15078 O15078 CEP290 PTHR18879:SF22 CENTROSOMAL PROTEIN OF 290 KDA CENTROSOMAL PROTEIN OF 290 KDA developmental process#GO:0032502;plasma membrane bounded cell projection assembly#GO:0120031;sensory organ development#GO:0007423;animal organ development#GO:0048513;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cell projection assembly#GO:0030031;sensory system development#GO:0048880;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;kidney development#GO:0001822;renal system development#GO:0072001;plasma membrane bounded cell projection organization#GO:0120036;multicellular organismal process#GO:0032501;cellular component assembly#GO:0022607;animal gross anatomical part developmental process#GO:0160108;organelle assembly#GO:0070925;camera-type eye development#GO:0043010;eye development#GO:0001654;cilium organization#GO:0044782;system development#GO:0048731;anatomical structure development#GO:0048856;non-motile cilium assembly#GO:1905515;ciliary transition zone assembly#GO:1905349;cellular component organization#GO:0016043;cilium assembly#GO:0060271;visual system development#GO:0150063;cell projection organization#GO:0030030 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ciliary transition zone#GO:0035869;cilium#GO:0005929;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;centriolar satellite#GO:0034451;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;centrosome#GO:0005813;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630 HUMAN|HGNC=8030|UniProtKB=O00634 O00634 NTN3 PTHR10574:SF292 NETRIN/LAMININ-RELATED NETRIN-3 developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;axon development#GO:0061564;axon guidance#GO:0007411;plasma membrane bounded cell projection organization#GO:0120036;tissue development#GO:0009888;multicellular organismal process#GO:0032501;system development#GO:0048731;anatomical structure development#GO:0048856;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell projection morphogenesis#GO:0048858;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;neuron projection development#GO:0031175;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;neuron development#GO:0048666;axonogenesis#GO:0007409;dendrite development#GO:0016358;anatomical structure morphogenesis#GO:0009653;motor neuron axon guidance#GO:0008045;cellular component organization#GO:0016043;cell development#GO:0048468;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell morphogenesis#GO:0000902 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576;basement membrane#GO:0005604;cellular anatomical structure#GO:0110165 extracellular matrix protein#PC00102 Axon guidance mediated by Slit/Robo#P00008>Netrin#P00344;Axon guidance mediated by netrin#P00009>Netrin#P00357 HUMAN|HGNC=3621|UniProtKB=P55899 P55899 FCGRT PTHR16675:SF3 MHC CLASS I-RELATED IGG RECEPTOR FCRN LARGE SUBUNIT P51 immune response#GO:0006955;immune system process#GO:0002376;response to stimulus#GO:0050896 external side of plasma membrane#GO:0009897;extracellular region#GO:0005576;side of membrane#GO:0098552;membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;plasma membrane#GO:0005886 defense/immunity protein#PC00090;major histocompatibility complex protein#PC00149 HUMAN|HGNC=324|UniProtKB=Q99943 Q99943 AGPAT1 PTHR10434:SF65 1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE 1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE ALPHA transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 glycerophospholipid metabolic process#GO:0006650;glycerolipid metabolic process#GO:0046486;phospholipid biosynthetic process#GO:0008654;lipid biosynthetic process#GO:0008610;phospholipid metabolic process#GO:0006644;biosynthetic process#GO:0009058;organophosphate metabolic process#GO:0019637;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;organophosphate biosynthetic process#GO:0090407;metabolic process#GO:0008152;glycerophospholipid biosynthetic process#GO:0046474;lipid metabolic process#GO:0006629 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 acyltransferase#PC00042;transferase#PC00220 HUMAN|HGNC=11480|UniProtKB=O95425 O95425 SVIL PTHR11977:SF45 VILLIN SUPERVILLIN phospholipid binding#GO:0005543;cytoskeletal protein binding#GO:0008092;phosphatidylinositol phosphate binding#GO:1901981;phosphatidylinositol-4,5-bisphosphate binding#GO:0005546;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;binding#GO:0005488;actin binding#GO:0003779;actin filament binding#GO:0051015;phosphatidylinositol bisphosphate binding#GO:1902936;protein binding#GO:0005515;lipid binding#GO:0008289;protein-containing complex binding#GO:0044877 negative regulation of protein-containing complex assembly#GO:0031333;supramolecular fiber organization#GO:0097435;negative regulation of cytoskeleton organization#GO:0051494;negative regulation of protein-containing complex disassembly#GO:0043242;actin filament capping#GO:0051693;negative regulation of protein polymerization#GO:0032272;actin filament-based process#GO:0030029;regulation of actin filament depolymerization#GO:0030834;regulation of cytoskeleton organization#GO:0051493;regulation of protein polymerization#GO:0032271;negative regulation of supramolecular fiber organization#GO:1902904;regulation of cellular process#GO:0050794;actin cytoskeleton organization#GO:0030036;regulation of supramolecular fiber organization#GO:1902903;negative regulation of organelle organization#GO:0010639;negative regulation of cellular component organization#GO:0051129;actin filament organization#GO:0007015;regulation of protein depolymerization#GO:1901879;regulation of actin filament-based process#GO:0032970;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;regulation of actin polymerization or depolymerization#GO:0008064;negative regulation of protein depolymerization#GO:1901880;regulation of actin filament polymerization#GO:0030833;actin polymerization or depolymerization#GO:0008154;regulation of actin filament organization#GO:0110053;negative regulation of actin filament depolymerization#GO:0030835;regulation of biological quality#GO:0065008;regulation of actin filament length#GO:0030832;negative regulation of actin filament polymerization#GO:0030837;regulation of cellular component biogenesis#GO:0044087;regulation of cellular component organization#GO:0051128;regulation of biological process#GO:0050789;regulation of cellular component size#GO:0032535;regulation of organelle organization#GO:0033043;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;regulation of protein-containing complex assembly#GO:0043254;cellular component organization or biogenesis#GO:0071840;regulation of anatomical structure size#GO:0090066;cytoskeleton organization#GO:0007010;regulation of actin cytoskeleton organization#GO:0032956;cellular process#GO:0009987;organelle organization#GO:0006996;regulation of protein-containing complex disassembly#GO:0043244 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;actin cytoskeleton#GO:0015629;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737 actin or actin-binding cytoskeletal protein#PC00041;non-motor actin binding protein#PC00165 HUMAN|HGNC=24488|UniProtKB=Q8NBT0 Q8NBT0 POC1A PTHR44019:SF2 WD REPEAT-CONTAINING PROTEIN 55 POC1 CENTRIOLAR PROTEIN HOMOLOG A plasma membrane bounded cell projection assembly#GO:0120031;organelle assembly#GO:0070925;cilium organization#GO:0044782;cellular component organization or biogenesis#GO:0071840;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cilium assembly#GO:0060271;cellular component organization#GO:0016043;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cell projection organization#GO:0030030 microtubule cytoskeleton#GO:0015630;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;centriole#GO:0005814;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cilium#GO:0005929;intracellular organelle#GO:0043229;microtubule organizing center#GO:0005815;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 non-motor microtubule binding protein#PC00166;cytoskeletal protein#PC00085 HUMAN|HGNC=28308|UniProtKB=Q6UXB0 Q6UXB0 FAM131A PTHR15736:SF4 PROTEIN FAM131B-RELATED PROTEIN FAM131A HUMAN|HGNC=3432|UniProtKB=Q15303 Q15303 ERBB4 PTHR24416:SF90 TYROSINE-PROTEIN KINASE RECEPTOR RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4 transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488;protein kinase activity#GO:0004672;protein binding#GO:0005515;phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity#GO:0016740;signaling receptor activity#GO:0038023;signaling receptor binding#GO:0005102;molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714;transferase activity, transferring phosphorus-containing groups#GO:0016772;growth factor receptor binding#GO:0070851;protein tyrosine kinase activity#GO:0004713;catalytic activity#GO:0003824;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity, acting on a protein#GO:0140096 multicellular organism development#GO:0007275;cell surface receptor signaling pathway#GO:0007166;regulation of apoptotic process#GO:0042981;neuron differentiation#GO:0030182;regulation of MAPK cascade#GO:0043408;nervous system development#GO:0007399;cellular process#GO:0009987;negative regulation of programmed cell death#GO:0043069;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;generation of neurons#GO:0048699;regulation of intracellular signal transduction#GO:1902531;animal gross anatomical part developmental process#GO:0160108;signaling#GO:0023052;response to stimulus#GO:0050896;cell differentiation#GO:0030154;regulation of biological process#GO:0050789;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;positive regulation of cell population proliferation#GO:0008284;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;positive regulation of MAPK cascade#GO:0043410;regulation of response to stimulus#GO:0048583;developmental process#GO:0032502;positive regulation of intracellular signal transduction#GO:1902533;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;epidermal growth factor receptor signaling pathway#GO:0007173;multicellular organismal process#GO:0032501;negative regulation of apoptotic process#GO:0043066;positive regulation of response to stimulus#GO:0048584;ERBB signaling pathway#GO:0038127;positive regulation of cellular process#GO:0048522;system development#GO:0048731;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;regulation of cell population proliferation#GO:0042127;cell communication#GO:0007154;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of cell communication#GO:0010646;positive regulation of epithelial cell proliferation#GO:0050679;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967 plasma membrane#GO:0005886;plasma membrane region#GO:0098590;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;basal plasma membrane#GO:0009925;cell periphery#GO:0071944;basal part of cell#GO:0045178;membrane#GO:0016020;signaling receptor complex#GO:0043235 transmembrane signal receptor#PC00197 Cadherin signaling pathway#P00012>EGFR#P00466;Alzheimer disease-presenilin pathway#P00004>Erb-B4 transmembrane fragment#P00113;Alzheimer disease-presenilin pathway#P00004>Erb-B4 C-terminal fragment#P00163;Alzheimer disease-presenilin pathway#P00004>Erb-B4#P00128;Alzheimer disease-presenilin pathway#P00004>Erb-B4 N-terminal fragment#P00148;EGF receptor signaling pathway#P00018>EGFR#P00542 HUMAN|HGNC=4068|UniProtKB=Q9H0R8 Q9H0R8 GABARAPL1 PTHR10969:SF30 MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED GAMMA-AMINOBUTYRIC ACID RECEPTOR-ASSOCIATED PROTEIN-LIKE 1 GABA receptor binding#GO:0050811;phospholipid binding#GO:0005543;ubiquitin-like protein ligase binding#GO:0044389;ubiquitin protein ligase binding#GO:0031625;binding#GO:0005488;signaling receptor binding#GO:0005102;enzyme binding#GO:0019899;protein binding#GO:0005515;lipid binding#GO:0008289 catabolic process#GO:0009056;response to stimulus#GO:0050896;protein-containing complex disassembly#GO:0032984;response to starvation#GO:0042594;cellular component organization#GO:0016043;cellular response to stimulus#GO:0051716;cellular component disassembly#GO:0022411;vacuole organization#GO:0007033;process utilizing autophagic mechanism#GO:0061919;organelle assembly#GO:0070925;cellular response to stress#GO:0033554;cellular component assembly#GO:0022607;macroautophagy#GO:0016236;response to nutrient levels#GO:0031667;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;response to stress#GO:0006950;autophagy#GO:0006914;autophagosome organization#GO:1905037;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;mitophagy#GO:0000423;protein-containing complex organization#GO:0043933;autophagosome assembly#GO:0000045;cellular response to starvation#GO:0009267;metabolic process#GO:0008152;autophagosome maturation#GO:0097352;autophagy of mitochondrion#GO:0000422;cellular response to nutrient levels#GO:0031669 vacuolar membrane#GO:0005774;autophagosome membrane#GO:0000421;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane-bounded organelle#GO:0043227;autophagosome#GO:0005776;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;vacuole#GO:0005773;membrane#GO:0016020 microtubule or microtubule-binding cytoskeletal protein#PC00157;cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HUMAN|HGNC=22968|UniProtKB=P60369 P60369 KRTAP10-3 PTHR23262:SF175 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 10-3 structural protein#PC00211 HUMAN|HGNC=17941|UniProtKB=Q9P121 Q9P121 NTM PTHR42757:SF9 IGLON FAMILY OF IMMUNOGLOBULIN SUPERFAMILY-RELATED NEUROTRIMIN regulation of cellular component biogenesis#GO:0044087;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of synapse assembly#GO:0051963;heterophilic cell-cell adhesion#GO:0007157;cellular process#GO:0009987;regulation of biological process#GO:0050789;cell-cell adhesion#GO:0098609;regulation of biological quality#GO:0065008;regulation of synapse structure or activity#GO:0050803;regulation of synapse organization#GO:0050807;regulation of cell junction assembly#GO:1901888;cell adhesion#GO:0007155 membrane#GO:0016020;presynapse#GO:0098793;cell periphery#GO:0071944;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;neuron to neuron synapse#GO:0098984;plasma membrane#GO:0005886;presynaptic membrane#GO:0042734;synaptic membrane#GO:0097060;cell junction#GO:0030054;presynaptic active zone#GO:0048786;postsynapse#GO:0098794;presynaptic active zone membrane#GO:0048787;organelle#GO:0043226;asymmetric synapse#GO:0032279;synapse#GO:0045202;cellular anatomical structure#GO:0110165;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;postsynaptic density#GO:0014069;postsynaptic density membrane#GO:0098839 immunoglobulin#PC00123 HUMAN|HGNC=3192|UniProtKB=Q05639 Q05639 EEF1A2 PTHR23115:SF228 TRANSLATION FACTOR ELONGATION FACTOR 1-ALPHA 2 hydrolase activity#GO:0016787;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;translation elongation factor activity#GO:0003746;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;translation factor activity#GO:0180051;hydrolase activity, acting on acid anhydrides#GO:0016817 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;translational elongation#GO:0006414;metabolic process#GO:0008152;translation#GO:0006412;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 translation factor#PC00223 HUMAN|HGNC=8925|UniProtKB=P46020 P46020 PHKA1 PTHR10749:SF4 PHOSPHORYLASE B KINASE REGULATORY SUBUNIT PHOSPHORYLASE B KINASE REGULATORY SUBUNIT ALPHA, SKELETAL MUSCLE ISOFORM intracellular anatomical structure#GO:0005622;protein kinase complex#GO:1902911;serine/threonine protein kinase complex#GO:1902554;transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;transferase complex#GO:1990234;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737 kinase activator#PC00138 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Phosphorylase b kinase#P00716 HUMAN|HGNC=681|UniProtKB=Q92888 Q92888 ARHGEF1 PTHR45872:SF4 RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 1 G protein-coupled receptor binding#GO:0001664;molecular function regulator activity#GO:0098772;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;guanyl-nucleotide exchange factor activity#GO:0005085;signaling receptor binding#GO:0005102;binding#GO:0005488;enzyme regulator activity#GO:0030234;protein binding#GO:0005515 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 guanyl-nucleotide exchange factor#PC00113 Axon guidance mediated by semaphorins#P00007>RhoGEF#P00333;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>RhoGEF#P00728;Cytoskeletal regulation by Rho GTPase#P00016>Rho GEFs#P00518 HUMAN|HGNC=19667|UniProtKB=Q8TBZ3 Q8TBZ3 WDR20 PTHR14107:SF5 WD REPEAT PROTEIN WD REPEAT-CONTAINING PROTEIN 20 peptidase activator activity#GO:0016504;peptidase regulator activity#GO:0061134;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234 regulation of catabolic process#GO:0009894;negative regulation of ubiquitin-dependent protein catabolic process#GO:2000059;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;negative regulation of protein catabolic process#GO:0042177;negative regulation of macromolecule metabolic process#GO:0010605;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of protein catabolic process#GO:0042176;negative regulation of catabolic process#GO:0009895;negative regulation of protein metabolic process#GO:0051248;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519 nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=25788|UniProtKB=Q5T2E6 Q5T2E6 ARMH3 PTHR13608:SF3 ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 3 ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 3 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 HUMAN|HGNC=11048|UniProtKB=P23975 P23975 SLC6A2 PTHR11616:SF336 SODIUM/CHLORIDE DEPENDENT TRANSPORTER SODIUM-DEPENDENT NORADRENALINE TRANSPORTER symporter activity#GO:0015293;monoatomic cation transmembrane transporter activity#GO:0008324;solute:sodium symporter activity#GO:0015370;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoamine transmembrane transporter activity#GO:0008504;secondary active transmembrane transporter activity#GO:0015291;monoatomic anion transmembrane transporter activity#GO:0008509;chloride transmembrane transporter activity#GO:0015108;sodium ion transmembrane transporter activity#GO:0015081;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294 trans-synaptic signaling#GO:0099537;organic hydroxy compound transport#GO:0015850;monoatomic ion transport#GO:0006811;cell communication#GO:0007154;localization#GO:0051179;monoatomic cation transport#GO:0006812;cellular localization#GO:0051641;transmembrane transport#GO:0055085;regulation of biological process#GO:0050789;sodium ion transport#GO:0006814;chemical synaptic transmission#GO:0007268;metal ion transport#GO:0030001;signaling#GO:0023052;anterograde trans-synaptic signaling#GO:0098916;transport#GO:0006810;amino acid transport#GO:0006865;establishment of localization#GO:0051234;import into cell#GO:0098657;sodium ion transmembrane transport#GO:0035725;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;synaptic transmission, dopaminergic#GO:0001963;nitrogen compound transport#GO:0071705;synaptic signaling#GO:0099536;monoatomic cation transmembrane transport#GO:0098655;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;neurotransmitter transport#GO:0006836;monoatomic ion transmembrane transport#GO:0034220 axon#GO:0030424;neuronal cell body#GO:0043025;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165;synapse#GO:0045202;cell body#GO:0044297;cell junction#GO:0030054;synaptic membrane#GO:0097060;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;presynaptic membrane#GO:0042734;plasma membrane region#GO:0098590;neuron projection#GO:0043005;presynapse#GO:0098793;cell periphery#GO:0071944;membrane#GO:0016020 primary active transporter#PC00068 Adrenaline and noradrenaline biosynthesis#P00001>NET#P00064 HUMAN|HGNC=8691|UniProtKB=Q9Y5E3 Q9Y5E3 PCDHB6 PTHR24028:SF104 CADHERIN-87A PROTOCADHERIN BETA-6 cell adhesion#GO:0007155;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 cadherin#PC00057;cell adhesion molecule#PC00069 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HUMAN|HGNC=16503|UniProtKB=Q8NFQ6 Q8NFQ6 BPIFC PTHR10504:SF17 BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED BPI FOLD-CONTAINING FAMILY C PROTEIN cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090 HUMAN|HGNC=24534|UniProtKB=O76021 O76021 RSL1D1 PTHR23105:SF31 RIBOSOMAL PROTEIN L7AE FAMILY MEMBER RIBOSOMAL L1 DOMAIN-CONTAINING PROTEIN 1 nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 translational protein#PC00263;ribosomal protein#PC00202 HUMAN|HGNC=20726|UniProtKB=Q8WVM8 Q8WVM8 SCFD1 PTHR11679:SF2 VESICLE PROTEIN SORTING-ASSOCIATED SEC1 FAMILY DOMAIN-CONTAINING PROTEIN 1 binding#GO:0005488;SNARE binding#GO:0000149;protein binding#GO:0005515;syntaxin binding#GO:0019905 localization#GO:0051179;cellular localization#GO:0051641;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;protein transport#GO:0015031;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;transport#GO:0006810;Golgi vesicle transport#GO:0048193;intracellular protein transport#GO:0006886;vesicle-mediated transport#GO:0016192;macromolecule localization#GO:0033036;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987 organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;membrane#GO:0016020 membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=17631|UniProtKB=Q9GZS1 Q9GZS1 POLR1E PTHR14440:SF7 DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49 DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49 cellular component organization#GO:0016043;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;protein-containing complex assembly#GO:0065003;DNA-templated transcription initiation#GO:0006352;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;cellular component biogenesis#GO:0044085;DNA-templated transcription elongation#GO:0006354;transcription by RNA polymerase I#GO:0006360;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component assembly#GO:0022607;gene expression#GO:0010467;protein-DNA complex assembly#GO:0065004;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;protein-DNA complex organization#GO:0071824;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;transcription initiation at RNA polymerase I promoter#GO:0006361;protein-containing complex organization#GO:0043933 intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;membrane-enclosed lumen#GO:0031974;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;organelle lumen#GO:0043233;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;membrane-bounded organelle#GO:0043227;RNA polymerase I complex#GO:0005736;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695 DNA-directed RNA polymerase#PC00019 HUMAN|HGNC=3672|UniProtKB=O43320 O43320 FGF16 PTHR11486:SF27 FIBROBLAST GROWTH FACTOR FIBROBLAST GROWTH FACTOR 16 molecular function activator activity#GO:0140677;protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;fibroblast growth factor receptor binding#GO:0005104;growth factor activity#GO:0008083;growth factor receptor binding#GO:0070851;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018 cell differentiation#GO:0030154;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;signaling#GO:0023052;response to endogenous stimulus#GO:0009719;positive regulation of cell population proliferation#GO:0008284;regulation of biological process#GO:0050789;positive regulation of signaling#GO:0023056;cellular response to growth factor stimulus#GO:0071363;regulation of intracellular signal transduction#GO:1902531;animal gross anatomical part developmental process#GO:0160108;regulation of signaling#GO:0023051;nervous system development#GO:0007399;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular response to fibroblast growth factor stimulus#GO:0044344;cellular process#GO:0009987;multicellular organism development#GO:0007275;regulation of MAPK cascade#GO:0043408;cell surface receptor signaling pathway#GO:0007166;response to growth factor#GO:0070848;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;regulation of cell motility#GO:2000145;regulation of cell population proliferation#GO:0042127;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;system development#GO:0048731;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of response to stimulus#GO:0048584;fibroblast growth factor receptor signaling pathway#GO:0008543;multicellular organismal process#GO:0032501;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;positive regulation of cellular process#GO:0048522;positive regulation of MAPK cascade#GO:0043410;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;response to fibroblast growth factor#GO:0071774;positive regulation of intracellular signal transduction#GO:1902533;developmental process#GO:0032502;regulation of cell migration#GO:0030334;regulation of response to stimulus#GO:0048583 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 growth factor#PC00112;intercellular signal molecule#PC00207 FGF signaling pathway#P00021>FGF#P00623 HUMAN|HGNC=19174|UniProtKB=Q96MX0 Q96MX0 CMTM3 PTHR22776:SF3 MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN CKLF-LIKE MARVEL TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 3 immune system process#GO:0002376;regulation of biological process#GO:0050789;immune response#GO:0006955;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052 vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HUMAN|HGNC=16915|UniProtKB=O00165 O00165 HAX1 PTHR14938:SF2 HCLS1-ASSOCIATED PROTEIN X-1 HCLS1-ASSOCIATED PROTEIN X-1 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;signaling adaptor activity#GO:0035591 regulation of actin filament-based process#GO:0032970;regulation of actin filament organization#GO:0110053;biological regulation#GO:0065007;regulation of actin polymerization or depolymerization#GO:0008064;regulation of actin filament polymerization#GO:0030833;cytokine-mediated signaling pathway#GO:0019221;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of supramolecular fiber organization#GO:1902903;regulation of cellular process#GO:0050794;regulation of cytoskeleton organization#GO:0051493;regulation of protein polymerization#GO:0032271;cell surface receptor signaling pathway#GO:0007166;regulation of anatomical structure size#GO:0090066;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of actin cytoskeleton organization#GO:0032956;response to chemical#GO:0042221;response to cytokine#GO:0034097;regulation of actin filament length#GO:0030832;response to peptide#GO:1901652;regulation of biological quality#GO:0065008;regulation of organelle organization#GO:0033043;cellular response to cytokine stimulus#GO:0071345;regulation of cellular component size#GO:0032535;regulation of biological process#GO:0050789;regulation of protein-containing complex assembly#GO:0043254;cellular component organization#GO:0016043;regulation of cellular component biogenesis#GO:0044087;signaling#GO:0023052;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896 endomembrane system#GO:0012505;plasma membrane region#GO:0098590;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;sarcoplasmic reticulum#GO:0016529;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;clathrin-coated vesicle#GO:0030136;endoplasmic reticulum#GO:0005783;apical part of cell#GO:0045177;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;apical plasma membrane#GO:0016324;actin cytoskeleton#GO:0015629;vesicle#GO:0031982;mitochondrion#GO:0005739;coated vesicle#GO:0030135;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;sarcoplasm#GO:0016528;intracellular organelle#GO:0043229 HUMAN|HGNC=14605|UniProtKB=P58397 P58397 ADAMTS12 PTHR13723:SF189 ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 12 catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;metalloendopeptidase activity#GO:0004222 extracellular structure organization#GO:0043062;proteolysis#GO:0006508;metabolic process#GO:0008152;external encapsulating structure organization#GO:0045229;protein metabolic process#GO:0019538;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;cellular component organization#GO:0016043;primary metabolic process#GO:0044238 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 metalloprotease#PC00153 HUMAN|HGNC=6735|UniProtKB=P07948 P07948 LYN PTHR24418:SF42 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE LYN signaling receptor binding#GO:0005102;binding#GO:0005488;non-membrane spanning protein tyrosine kinase activity#GO:0004715;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein binding#GO:0005515;protein kinase activity#GO:0004672;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096 immune system development#GO:0002520;neuron development#GO:0048666;immune system process#GO:0002376;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;cellular response to stress#GO:0033554;regulation of signaling#GO:0023051;cell differentiation#GO:0030154;cell projection organization#GO:0030030;response to stimulus#GO:0050896;signaling#GO:0023052;cell development#GO:0048468;leukocyte differentiation#GO:0002521;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;mononuclear cell differentiation#GO:1903131;immune response-regulating signaling pathway#GO:0002764;cellular component organization or biogenesis#GO:0071840;immune response-activating signaling pathway#GO:0002757;multicellular organism development#GO:0007275;neuron differentiation#GO:0030182;cell surface receptor signaling pathway#GO:0007166;nervous system development#GO:0007399;neuron projection development#GO:0031175;positive regulation of immune system process#GO:0002684;response to stress#GO:0006950;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;signal transduction#GO:0007165;cellular process#GO:0009987;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;system development#GO:0048731;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of immune response#GO:0050776;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of B cell receptor signaling pathway#GO:0050855;regulation of cell communication#GO:0010646;immune response-activating cell surface receptor signaling pathway#GO:0002429;cellular response to stimulus#GO:0051716;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;developmental process#GO:0032502;positive regulation of immune response#GO:0050778;DNA damage response#GO:0006974;regulation of response to stimulus#GO:0048583;positive regulation of response to stimulus#GO:0048584;multicellular organismal process#GO:0032501;regulation of signal transduction#GO:0009966;immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007;hemopoiesis#GO:0030097;plasma membrane bounded cell projection organization#GO:0120036 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 non-receptor tyrosine protein kinase#PC00168 B cell activation#P00010>Lyn#P00374;CCKR signaling map#P06959>LYN#P07141;Parkinson disease#P00049>Src kinase#P01230;Cadherin signaling pathway#P00012>Yes#P00476 HUMAN|HGNC=17792|UniProtKB=Q96AJ9 Q96AJ9 VTI1A PTHR21230:SF102 VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A SNAP receptor activity#GO:0005484;protein binding#GO:0005515;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;SNARE binding#GO:0000149 localization#GO:0051179;Golgi to vacuole transport#GO:0006896;vesicle fusion#GO:0006906;catabolic process#GO:0009056;Golgi organization#GO:0007030;intra-Golgi vesicle-mediated transport#GO:0006891;establishment of localization#GO:0051234;vacuolar transport#GO:0007034;transport#GO:0006810;intracellular transport#GO:0046907;membrane organization#GO:0061024;macroautophagy#GO:0016236;retrograde transport, endosome to Golgi#GO:0042147;membrane fusion#GO:0061025;post-Golgi vesicle-mediated transport#GO:0006892;process utilizing autophagic mechanism#GO:0061919;cellular localization#GO:0051641;cytosolic transport#GO:0016482;cellular component organization#GO:0016043;endosomal transport#GO:0016197;vesicle organization#GO:0016050;cellular component organization or biogenesis#GO:0071840;Golgi vesicle transport#GO:0048193;metabolic process#GO:0008152;endomembrane system organization#GO:0010256;organelle membrane fusion#GO:0090174;organelle fusion#GO:0048284;vesicle-mediated transport#GO:0016192;autophagy#GO:0006914;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle organization#GO:0006996 vesicle membrane#GO:0012506;membrane#GO:0016020;cytoplasm#GO:0005737;transport vesicle#GO:0030133;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;transport vesicle membrane#GO:0030658;protein-containing complex#GO:0032991;ER to Golgi transport vesicle membrane#GO:0012507;endoplasmic reticulum#GO:0005783;Golgi apparatus#GO:0005794;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;coated vesicle membrane#GO:0030662;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;SNARE complex#GO:0031201;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;coated vesicle#GO:0030135;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;COPII-coated ER to Golgi transport vesicle#GO:0030134 SNARE protein#PC00034;membrane traffic protein#PC00150 Metabotropic glutamate receptor group III pathway#P00039>SNARE Complex#P01042 HUMAN|HGNC=41913|UniProtKB=Q96HG1 Q96HG1 SMIM10 PTHR34446:SF4 SMALL INTEGRAL MEMBRANE PROTEIN 10 SMALL INTEGRAL MEMBRANE PROTEIN 10 HUMAN|HGNC=10555|UniProtKB=Q99700 Q99700 ATXN2 PTHR12854:SF11 ATAXIN 2-RELATED ATAXIN-2 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729 cytoplasmic stress granule assembly#GO:0034063;cellular component assembly#GO:0022607;cellular process#GO:0009987;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular component organization or biogenesis#GO:0071840;organelle assembly#GO:0070925 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic stress granule#GO:0010494;membraneless organelle#GO:0043228;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;organelle#GO:0043226 RNA metabolism protein#PC00031 HUMAN|HGNC=7684|UniProtKB=O95299 O95299 NDUFA10 PTHR10513:SF15 DEOXYNUCLEOSIDE KINASE NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 10, MITOCHONDRIAL transferase activity#GO:0016740;nucleobase-containing compound kinase activity#GO:0019205;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;deoxynucleoside kinase activity#GO:0019136 aerobic respiration#GO:0009060;energy derivation by oxidation of organic compounds#GO:0015980;cellular respiration#GO:0045333;ATP synthesis coupled electron transport#GO:0042773;oxidative phosphorylation#GO:0006119;mitochondrial electron transport, NADH to ubiquinone#GO:0006120;generation of precursor metabolites and energy#GO:0006091;aerobic electron transport chain#GO:0019646;metabolic process#GO:0008152;cellular process#GO:0009987;respiratory electron transport chain#GO:0022904;mitochondrial ATP synthesis coupled electron transport#GO:0042775;electron transport chain#GO:0022900 membrane protein complex#GO:0098796;oxidoreductase complex#GO:1990204;membrane#GO:0016020;respiratory chain complex#GO:0098803;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;catalytic complex#GO:1902494;respiratory chain complex I#GO:0045271;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;nucleotide kinase#PC00172 HUMAN|HGNC=9406|UniProtKB=Q16513 Q16513 PKN2 PTHR24356:SF322 SERINE/THREONINE-PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE N2 phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 non-receptor serine/threonine protein kinase#PC00167 Alzheimer disease-amyloid secretase pathway#P00003>PKC#P00109;PDGF signaling pathway#P00047>PKC#P01150;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>PKC#P01074 HUMAN|HGNC=7048|UniProtKB=Q9UQ53 Q9UQ53 MGAT4B PTHR12062:SF1 N-ACETYLGLUCOSAMINYLTRANSFERASE VI ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 4-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE B transferase activity#GO:0016740;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194;acetylglucosaminyltransferase activity#GO:0008375 carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;glycoprotein biosynthetic process#GO:0009101;protein N-linked glycosylation#GO:0006487;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;Golgi apparatus subcompartment#GO:0098791;Golgi stack#GO:0005795;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 transferase#PC00220 HUMAN|HGNC=886|UniProtKB=P46100 P46100 ATRX PTHR46357:SF1 TRANSCRIPTIONAL REGULATOR ATRX CHROMATIN REMODELER ATRX nucleic acid binding#GO:0003676;binding#GO:0005488;chromatin DNA binding#GO:0031490;chromatin binding#GO:0003682;DNA binding#GO:0003677 cellular component organization#GO:0016043;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular process#GO:0009987;DNA replication#GO:0006260;nucleobase-containing compound metabolic process#GO:0006139;chromatin organization#GO:0006325;chromatin remodeling#GO:0006338;replication fork processing#GO:0031297;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;macromolecule metabolic process#GO:0043170;DNA-templated DNA replication#GO:0006261;cellular component organization or biogenesis#GO:0071840 intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687;membrane-bounded organelle#GO:0043227;heterochromatin#GO:0000792;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;chromosome, centromeric region#GO:0000775;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=29228|UniProtKB=Q9ULI2 Q9ULI2 RIMKLB PTHR21621:SF5 RIBOSOMAL PROTEIN S6 MODIFICATION PROTEIN BETA-CITRYLGLUTAMATE SYNTHASE B catalytic activity#GO:0003824;ligase activity#GO:0016874;ligase activity, forming carbon-nitrogen bonds#GO:0016879 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 translational protein#PC00263;ribosomal protein#PC00202 HUMAN|HGNC=24708|UniProtKB=Q49AA0 Q49AA0 ZFP69 PTHR24381:SF74 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 69 HOMOLOG double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=10472|UniProtKB=Q13950 Q13950 RUNX2 PTHR11950:SF7 RUNT RELATED RUNT-RELATED TRANSCRIPTION FACTOR 2 cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of developmental process#GO:0050793;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;ossification#GO:0001503;system development#GO:0048731;cartilage development#GO:0051216;regulation of RNA metabolic process#GO:0051252;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;hemopoiesis#GO:0030097;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;chondrocyte differentiation#GO:0002062;tissue development#GO:0009888;multicellular organismal process#GO:0032501;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;connective tissue development#GO:0061448;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;developmental process#GO:0032502;regulation of cell differentiation#GO:0045595;cell development#GO:0048468;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of biological process#GO:0050789;skeletal system development#GO:0001501;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;nervous system development#GO:0007399;cellular process#GO:0009987;multicellular organism development#GO:0007275;animal organ development#GO:0048513;neuron differentiation#GO:0030182 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 DNA-binding transcription factor#PC00218;Runt transcription factor#PC00254 HUMAN|HGNC=19267|UniProtKB=Q8NFP4 Q8NFP4 MDGA1 PTHR23282:SF123 APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR. MAM DOMAIN-CONTAINING GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR PROTEIN 1 HUMAN|HGNC=13732|UniProtKB=Q9NNZ6 Q9NNZ6 PRM3 PTHR14317:SF0 SPERM PROTAMINE P3 PROTAMINE-3 cilium or flagellum-dependent cell motility#GO:0001539;cilium movement#GO:0003341;flagellated sperm motility#GO:0030317;microtubule-based process#GO:0007017;cilium-dependent cell motility#GO:0060285;cellular process#GO:0009987;sperm motility#GO:0097722;cilium movement involved in cell motility#GO:0060294;reproductive process#GO:0022414;microtubule-based movement#GO:0007018;cell motility#GO:0048870 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=18795|UniProtKB=O15205 O15205 UBD PTHR47731:SF1 UBIQUITIN D UBIQUITIN D protein-containing complex binding#GO:0044877;binding#GO:0005488 protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;protein modification process#GO:0036211;primary metabolic process#GO:0044238;positive regulation of signal transduction#GO:0009967;modification-dependent protein catabolic process#GO:0019941;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;catabolic process#GO:0009056;regulation of cell communication#GO:0010646;response to external biotic stimulus#GO:0043207;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;innate immune response#GO:0045087;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;defense response#GO:0006952;response to external stimulus#GO:0009605;response to tumor necrosis factor#GO:0034612;regulation of canonical NF-kappaB signal transduction#GO:0043122;positive regulation of cellular process#GO:0048522;immune response#GO:0006955;positive regulation of response to stimulus#GO:0048584;response to other organism#GO:0051707;post-translational protein modification#GO:0043687;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of intracellular signal transduction#GO:1902531;protein modification by small protein conjugation or removal#GO:0070647;immune system process#GO:0002376;regulation of signaling#GO:0023051;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;positive regulation of signaling#GO:0023056;response to peptide#GO:1901652;regulation of programmed cell death#GO:0043067;regulation of biological process#GO:0050789;protein modification by small protein conjugation#GO:0032446;positive regulation of programmed cell death#GO:0043068;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;regulation of apoptotic process#GO:0042981;positive regulation of canonical NF-kappaB signal transduction#GO:0043123;positive regulation of apoptotic process#GO:0043065;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;cellular process#GO:0009987;response to type II interferon#GO:0034341;positive regulation of biological process#GO:0048518;defense response to symbiont#GO:0140546;defense response to other organism#GO:0098542;response to cytokine#GO:0034097;response to chemical#GO:0042221;protein ubiquitination#GO:0016567 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=13630|UniProtKB=P0C1Z6 P0C1Z6 TFPT PTHR35084:SF1 TCF3 FUSION PARTNER TCF3 FUSION PARTNER DNA binding#GO:0003677;binding#GO:0005488;nucleic acid binding#GO:0003676 apoptotic signaling pathway#GO:0097190;positive regulation of apoptotic process#GO:0043065;regulation of apoptotic process#GO:0042981;biological regulation#GO:0065007;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cell communication#GO:0007154;regulation of cellular process#GO:0050794;positive regulation of programmed cell death#GO:0043068;response to stimulus#GO:0050896;signaling#GO:0023052;programmed cell death#GO:0012501;regulation of programmed cell death#GO:0043067;cell death#GO:0008219;apoptotic process#GO:0006915;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789 membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;Ino80 complex#GO:0031011;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;chromatin#GO:0000785;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;INO80-type complex#GO:0097346;intracellular organelle lumen#GO:0070013;ATPase complex#GO:1904949;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;organelle lumen#GO:0043233;SWI/SNF superfamily-type complex#GO:0070603 HUMAN|HGNC=51337|UniProtKB=A6NJ88 A6NJ88 SAGE2P PTHR12957:SF36 DEAD/H BOX POLYPEPTIDE 26/DICE1-RELATED SAGE1-LIKE PROTEIN-RELATED molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;snRNA 3'-end processing#GO:0034472;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;snRNA metabolic process#GO:0016073;RNA metabolic process#GO:0016070;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;gene expression#GO:0010467;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;snRNA processing#GO:0016180;RNA 3'-end processing#GO:0031123;macromolecule metabolic process#GO:0043170 nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;integrator complex#GO:0032039;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 RNA helicase#PC00032 HUMAN|HGNC=17127|UniProtKB=Q9NP94 Q9NP94 SLC39A2 PTHR11040:SF120 ZINC/IRON TRANSPORTER ZINC TRANSPORTER ZIP2 metal ion transmembrane transporter activity#GO:0046873;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;transition metal ion transmembrane transporter activity#GO:0046915;zinc ion transmembrane transporter activity#GO:0005385 cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;zinc ion transport#GO:0006829;transport#GO:0006810;inorganic cation import across plasma membrane#GO:0098659;establishment of localization#GO:0051234;import into cell#GO:0098657;metal ion transport#GO:0030001;inorganic ion import across plasma membrane#GO:0099587;import across plasma membrane#GO:0098739;zinc ion transmembrane transport#GO:0071577;transition metal ion transport#GO:0000041;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 secondary carrier transporter#PC00258 HUMAN|HGNC=8655|UniProtKB=Q08174 Q08174 PCDH1 PTHR24028:SF247 CADHERIN-87A PROTOCADHERIN-1 cell adhesion#GO:0007155;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HUMAN|HGNC=8023|UniProtKB=P20783 P20783 NTF3 PTHR11589:SF4 NERVE GROWTH FACTOR NGF -RELATED NEUROTROPHIN-3 signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;signaling receptor regulator activity#GO:0030545;growth factor activity#GO:0008083;receptor ligand activity#GO:0048018 cell projection morphogenesis#GO:0048858;cellular response to nerve growth factor stimulus#GO:1990090;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;regulation of apoptotic process#GO:0042981;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell surface receptor signaling pathway#GO:0007166;neuron differentiation#GO:0030182;nervous system development#GO:0007399;regulation of trans-synaptic signaling#GO:0099177;cellular process#GO:0009987;negative regulation of programmed cell death#GO:0043069;signal transduction#GO:0007165;negative regulation of neuron apoptotic process#GO:0043524;regulation of neuron apoptotic process#GO:0043523;neuron projection development#GO:0031175;neuron development#GO:0048666;cellular response to growth factor stimulus#GO:0071363;regulation of signaling#GO:0023051;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;signaling#GO:0023052;cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;cell differentiation#GO:0030154;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;response to endogenous stimulus#GO:0009719;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;negative regulation of apoptotic process#GO:0043066;system development#GO:0048731;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of cell communication#GO:0010646;modulation of chemical synaptic transmission#GO:0050804;regulation of cellular process#GO:0050794;response to growth factor#GO:0070848;cellular response to stimulus#GO:0051716 intracellular vesicle#GO:0097708;vesicle#GO:0031982;synaptic vesicle#GO:0008021;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;extracellular region#GO:0005576;exocytic vesicle#GO:0070382;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;secretory vesicle#GO:0099503;presynapse#GO:0098793;transport vesicle#GO:0030133;endomembrane system#GO:0012505;cytoplasm#GO:0005737;cell junction#GO:0030054 growth factor#PC00112;neurotrophic factor#PC00163 HUMAN|HGNC=32255|UniProtKB=A6NKC0 A6NKC0 FAM90A7 PTHR16035:SF14 PROTEIN FAM90A1 PROTEIN FAM90A10-RELATED HUMAN|HGNC=5637|UniProtKB=A0A075B7E8 A0A075B7E8 IGHV3OR16-13 PTHR23266:SF290 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 3_OR16-13 (NON-FUNCTIONAL) binding#GO:0005488;antigen binding#GO:0003823 response to stimulus#GO:0050896;adaptive immune response#GO:0002250;immune response#GO:0006955;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;immune system process#GO:0002376;immune effector process#GO:0002252 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=32035|UniProtKB=Q96NU0 Q96NU0 CNTNAP3B PTHR15036:SF36 PIKACHURIN-LIKE PROTEIN CONTACTIN ASSOCIATED PROTEIN FAMILY MEMBER 3C-RELATED developmental process#GO:0032502;multicellular organism development#GO:0007275;cellular process#GO:0009987;signal transduction#GO:0007165;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;biological regulation#GO:0065007;animal gross anatomical part developmental process#GO:0160108;anatomical structure development#GO:0048856;cell communication#GO:0007154;system development#GO:0048731;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cell junction#GO:0030054;cellular anatomical structure#GO:0110165;synapse#GO:0045202 cell adhesion molecule#PC00069 HUMAN|HGNC=23231|UniProtKB=Q96SA4 Q96SA4 SERINC2 PTHR10383:SF22 SERINE INCORPORATOR SERINE INCORPORATOR 2 cellular anatomical structure#GO:0110165;membrane#GO:0016020 protein-binding activity modulator#PC00095 HUMAN|HGNC=5604|UniProtKB=A0A0B4J1X8 A0A0B4J1X8 IGHV3-43 PTHR23266:SF236 IMMUNOGLOBULIN HEAVY CHAIN IG-LIKE DOMAIN-CONTAINING PROTEIN-RELATED binding#GO:0005488;antigen binding#GO:0003823 immune effector process#GO:0002252;immune system process#GO:0002376;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;immune response#GO:0006955;adaptive immune response#GO:0002250;response to stimulus#GO:0050896 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=6342|UniProtKB=P10721 P10721 KIT PTHR24416:SF46 TYROSINE-PROTEIN KINASE RECEPTOR MAST_STEM CELL GROWTH FACTOR RECEPTOR KIT signaling receptor activity#GO:0038023;transferase activity#GO:0016740;kinase activity#GO:0016301;protein binding#GO:0005515;growth factor binding#GO:0019838;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888;catalytic activity, acting on a protein#GO:0140096;transmembrane receptor protein kinase activity#GO:0019199;protein tyrosine kinase activity#GO:0004713;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714 positive regulation of signaling#GO:0023056;response to peptide#GO:1901652;immune system process#GO:0002376;regulation of signaling#GO:0023051;response to stimulus#GO:0050896;cell differentiation#GO:0030154;signaling#GO:0023052;cell development#GO:0048468;positive regulation of cell population proliferation#GO:0008284;positive regulation of cell motility#GO:2000147;leukocyte differentiation#GO:0002521;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;mononuclear cell differentiation#GO:1903131;B cell activation#GO:0042113;cell surface receptor signaling pathway#GO:0007166;response to chemical#GO:0042221;response to cytokine#GO:0034097;lymphocyte activation#GO:0046649;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;cell communication#GO:0007154;regulation of cell motility#GO:2000145;regulation of cell population proliferation#GO:0042127;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;cytokine-mediated signaling pathway#GO:0019221;positive regulation of receptor signaling pathway via JAK-STAT#GO:0046427;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;lymphocyte differentiation#GO:0030098;cell activation#GO:0001775;cell motility#GO:0048870;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of cell communication#GO:0010646;regulation of receptor signaling pathway via STAT#GO:1904892;leukocyte activation#GO:0045321;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;cellular developmental process#GO:0048869;positive regulation of locomotion#GO:0040017;regulation of cell migration#GO:0030334;developmental process#GO:0032502;regulation of response to stimulus#GO:0048583;regulation of receptor signaling pathway via JAK-STAT#GO:0046425;positive regulation of response to stimulus#GO:0048584;cell migration#GO:0016477;multicellular organismal process#GO:0032501;regulation of signal transduction#GO:0009966;hemopoiesis#GO:0030097;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;positive regulation of cellular process#GO:0048522;positive regulation of cell migration#GO:0030335 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;signaling receptor complex#GO:0043235 transmembrane signal receptor#PC00197 HUMAN|HGNC=12826|UniProtKB=O43592 O43592 XPOT PTHR15952:SF12 EXPORTIN-T/LOS1 EXPORTIN-T nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723;tRNA binding#GO:0000049 nitrogen compound transport#GO:0071705;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;transport#GO:0006810;establishment of localization#GO:0051234;RNA localization#GO:0006403;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;establishment of RNA localization#GO:0051236;nucleocytoplasmic transport#GO:0006913;cellular localization#GO:0051641;nucleic acid transport#GO:0050657;localization#GO:0051179;nuclear export#GO:0051168;nuclear transport#GO:0051169 nuclear pore#GO:0005643;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;nuclear envelope#GO:0005635;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle envelope#GO:0031967;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031 HUMAN|HGNC=7227|UniProtKB=O14807 O14807 MRAS PTHR24070:SF268 RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY RAS-RELATED PROTEIN M-RAS hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;establishment or maintenance of cell polarity#GO:0007163;Ras protein signal transduction#GO:0007265;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;intracellular signaling cassette#GO:0141124;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 small GTPase#PC00208 EGF receptor signaling pathway#P00018>Ras#P00552 HUMAN|HGNC=12006|UniProtKB=Q16890 Q16890 TPD52L1 PTHR19307:SF8 TUMOR PROTEIN D52 TUMOR PROTEIN D53 positive regulation of cellular process#GO:0048522;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of response to stimulus#GO:0048584;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;mitotic cell cycle process#GO:1903047;positive regulation of MAPK cascade#GO:0043410;cell cycle#GO:0007049;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;positive regulation of apoptotic signaling pathway#GO:2001235;mitotic cell cycle#GO:0000278;G2/M transition of mitotic cell cycle#GO:0000086;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;cell cycle phase transition#GO:0044770;regulation of apoptotic signaling pathway#GO:2001233;mitotic cell cycle phase transition#GO:0044772;cell cycle G2/M phase transition#GO:0044839;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of MAPK cascade#GO:0043408;regulation of apoptotic process#GO:0042981;positive regulation of apoptotic process#GO:0043065;regulation of JNK cascade#GO:0046328;regulation of biological process#GO:0050789;cell cycle process#GO:0022402;regulation of programmed cell death#GO:0043067;positive regulation of programmed cell death#GO:0043068;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;positive regulation of JNK cascade#GO:0046330;positive regulation of signaling#GO:0023056 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=6316|UniProtKB=Q92945 Q92945 KHSRP PTHR10288:SF101 KH DOMAIN CONTAINING RNA BINDING PROTEIN FAR UPSTREAM ELEMENT-BINDING PROTEIN 2 nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;mRNA 3'-UTR binding#GO:0003730;RNA binding#GO:0003723 regulation of RNA stability#GO:0043487;regulation of RNA metabolic process#GO:0051252;regulation of biological quality#GO:0065008;regulation of biological process#GO:0050789;regulation of mRNA catabolic process#GO:0061013;regulation of mRNA stability#GO:0043488;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;post-transcriptional regulation of gene expression#GO:0010608;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of mRNA metabolic process#GO:1903311;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031 HUMAN|HGNC=5563|UniProtKB=A0A075B7D0 A0A075B7D0 IGHV1OR15-1 PTHR23266:SF359 IMMUNOGLOBULIN HEAVY CHAIN IG-LIKE DOMAIN-CONTAINING PROTEIN binding#GO:0005488;antigen binding#GO:0003823 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;immune effector process#GO:0002252;immune system process#GO:0002376;adaptive immune response#GO:0002250;response to stimulus#GO:0050896;immune response#GO:0006955 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=15990|UniProtKB=P28676 P28676 GCA PTHR46735:SF5 CALPAIN, SMALL SUBUNIT 1 A-RELATED GRANCALCIN metal ion binding#GO:0046872;cation binding#GO:0043169;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;calcium ion binding#GO:0005509 HUMAN|HGNC=9644|UniProtKB=Q06124 Q06124 PTPN11 PTHR46559:SF1 TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11 TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11 protein tyrosine kinase binding#GO:1990782;signaling receptor binding#GO:0005102;hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;receptor tyrosine kinase binding#GO:0030971;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on a protein#GO:0140096;binding#GO:0005488;kinase binding#GO:0019900;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;protein tyrosine phosphatase activity#GO:0004725;protein binding#GO:0005515;cell adhesion molecule binding#GO:0050839;phosphoric ester hydrolase activity#GO:0042578 positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of cell communication#GO:0010646;positive regulation of ERK1 and ERK2 cascade#GO:0070374;signaling#GO:0023052;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of signaling#GO:0023056;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cellular process#GO:0009987;ERBB signaling pathway#GO:0038127;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;regulation of ERK1 and ERK2 cascade#GO:0070372;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166;positive regulation of intracellular signal transduction#GO:1902533;regulation of MAPK cascade#GO:0043408;positive regulation of MAPK cascade#GO:0043410 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protein phosphatase#PC00195;protein modifying enzyme#PC00260 FGF signaling pathway#P00021>SHP2#P00647;CCKR signaling map#P06959>SHP-2#P07028;Interferon-gamma signaling pathway#P00035>PTP#P00960;Angiogenesis#P00005>SHP2#P00181 HUMAN|HGNC=26937|UniProtKB=O43715 O43715 TRIAP1 PTHR46403:SF3 TP53-REGULATED INHIBITOR OF APOPTOSIS 1 TP53-REGULATED INHIBITOR OF APOPTOSIS 1 transporter activity#GO:0005215;molecular carrier activity#GO:0140104;lipid carrier activity#GO:0005319;lipid transfer activity#GO:0120013;phospholipid transfer activity#GO:0120014 negative regulation of apoptotic process#GO:0043066;lipid transport#GO:0006869;biological regulation#GO:0065007;phospholipid transport#GO:0015914;intermembrane phospholipid transfer#GO:0120010;membrane organization#GO:0061024;macromolecule localization#GO:0033036;negative regulation of programmed cell death#GO:0043069;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;intermembrane lipid transfer#GO:0120009;negative regulation of cellular process#GO:0048523;regulation of apoptotic process#GO:0042981;transport#GO:0006810;organophosphate ester transport#GO:0015748;regulation of cellular process#GO:0050794;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;localization#GO:0051179;lipid localization#GO:0010876 mitochondrial envelope#GO:0005740;mitochondrion#GO:0005739;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;organelle envelope#GO:0031967;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;mitochondrial intermembrane space#GO:0005758;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=30802|UniProtKB=Q96AD5 Q96AD5 PNPLA2 PTHR12406:SF29 CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 IPLA2 -RELATED PATATIN-LIKE PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN 2 carboxylic ester hydrolase activity#GO:0052689;triacylglycerol lipase activity#GO:0004806;acyltransferase activity#GO:0016746;lipase activity#GO:0016298;hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 metabolic process#GO:0008152;acylglycerol metabolic process#GO:0006639;neutral lipid catabolic process#GO:0046461;triglyceride metabolic process#GO:0006641;chemical homeostasis#GO:0048878;lipid metabolic process#GO:0006629;neutral lipid metabolic process#GO:0006638;cellular component organization or biogenesis#GO:0071840;acylglycerol catabolic process#GO:0046464;organelle organization#GO:0006996;lipid catabolic process#GO:0016042;cellular process#GO:0009987;triglyceride catabolic process#GO:0019433;lipid droplet organization#GO:0034389;glycerolipid catabolic process#GO:0046503;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;lipid homeostasis#GO:0055088;glycerolipid metabolic process#GO:0046486;catabolic process#GO:0009056;homeostatic process#GO:0042592 membraneless organelle#GO:0043228;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membraneless organelle#GO:0043232;lipid droplet#GO:0005811;intracellular organelle#GO:0043229 phospholipase#PC00186 HUMAN|HGNC=22932|UniProtKB=Q9Y5P6 Q9Y5P6 GMPPB PTHR22572:SF15 SUGAR-1-PHOSPHATE GUANYL TRANSFERASE MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE CATALYTIC SUBUNIT BETA transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;glycoprotein biosynthetic process#GO:0009101;organophosphate metabolic process#GO:0019637;nucleotide-sugar metabolic process#GO:0009225;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;glycoprotein metabolic process#GO:0009100;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;nucleoside phosphate biosynthetic process#GO:1901293;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;organophosphate biosynthetic process#GO:0090407;protein metabolic process#GO:0019538 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 transferase#PC00220 Mannose metabolism#P02752>Mannose 1-P guanylyl transferase#P03018 HUMAN|HGNC=12115|UniProtKB=A0A0A6YYK7 A0A0A6YYK7 TRAV19 PTHR23267:SF450 IMMUNOGLOBULIN LIGHT CHAIN T CELL RECEPTOR ALPHA VARIABLE 19 immune system process#GO:0002376;immune response#GO:0006955;response to stimulus#GO:0050896 protein-containing complex#GO:0032991 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=12816|UniProtKB=Q01831 Q01831 XPC PTHR12135:SF3 DNA REPAIR PROTEIN XP-C / RAD4 DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS molecular function regulator activity#GO:0098772;molecular sensor activity#GO:0140299 metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;DNA damage response#GO:0006974;cellular response to stress#GO:0033554;macromolecule metabolic process#GO:0043170;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;primary metabolic process#GO:0044238;mismatch repair#GO:0006298;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;nucleotide-excision repair#GO:0006289;nucleobase-containing compound metabolic process#GO:0006139 nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleotide-excision repair complex#GO:0000109;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 DNA metabolism protein#PC00009;damaged DNA-binding protein#PC00086 HUMAN|HGNC=9891|UniProtKB=Q99708 Q99708 RBBP8 PTHR15107:SF4 RETINOBLASTOMA BINDING PROTEIN 8 DNA ENDONUCLEASE RBBP8 damaged DNA binding#GO:0003684;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA binding#GO:0003677 cellular response to stress#GO:0033554;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;double-strand break repair via single-strand annealing#GO:0045002;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;DNA double-strand break processing#GO:0000729;double-strand break repair#GO:0006302;response to stress#GO:0006950;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139 transcription cofactor#PC00217 HUMAN|HGNC=10661|UniProtKB=P31431 P31431 SDC4 PTHR10915:SF3 SYNDECAN SYNDECAN-4 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 positive regulation of cellular component organization#GO:0051130;positive regulation of organelle organization#GO:0010638;regulation of organelle assembly#GO:1902115;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;regulation of cellular component organization#GO:0051128;positive regulation of cellular component biogenesis#GO:0044089;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of cellular component biogenesis#GO:0044087 cellular anatomical structure#GO:0110165;cell junction#GO:0030054;cell surface#GO:0009986;anchoring junction#GO:0070161;cell-substrate junction#GO:0030055;focal adhesion#GO:0005925 transmembrane signal receptor#PC00197 HUMAN|HGNC=2799|UniProtKB=Q6ISB3 Q6ISB3 GRHL2 PTHR11037:SF17 TRANSCRIPTION FACTOR CP2 GRAINYHEAD-LIKE PROTEIN 2 HOMOLOG transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription activator activity#GO:0001216;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;sequence-specific DNA binding#GO:0043565;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;sequence-specific double-stranded DNA binding#GO:1990837 regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;central nervous system development#GO:0007417;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;embryo development ending in birth or egg hatching#GO:0009792;animal gross anatomical part developmental process#GO:0160108;chordate embryonic development#GO:0043009;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;head development#GO:0060322;embryo development#GO:0009790;tube development#GO:0035295;nervous system development#GO:0007399;epithelium development#GO:0060429;regulation of nucleobase-containing compound metabolic process#GO:0019219;brain development#GO:0007420;multicellular organismal process#GO:0032501;tissue development#GO:0009888;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;multicellular organism development#GO:0007275;regulation of biosynthetic process#GO:0009889;animal organ development#GO:0048513;developmental process#GO:0032502 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 DNA-binding transcription factor#PC00218 HUMAN|HGNC=3701|UniProtKB=P49789 P49789 FHIT PTHR46981:SF1 BIS(5'-ADENOSYL)-TRIPHOSPHATASE BIS(5'-ADENOSYL)-TRIPHOSPHATASE ubiquitin protein ligase binding#GO:0031625;hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;ubiquitin-like protein ligase binding#GO:0044389;catalytic activity#GO:0003824;protein binding#GO:0005515;hydrolase activity#GO:0016787;enzyme binding#GO:0019899;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488 regulation of catabolic process#GO:0009894;apoptotic signaling pathway#GO:0097190;negative regulation of cellular process#GO:0048523;nucleotide catabolic process#GO:0009166;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;nucleobase-containing compound catabolic process#GO:0034655;organophosphate metabolic process#GO:0019637;regulation of primary metabolic process#GO:0080090;intracellular signal transduction#GO:0035556;regulation of protein catabolic process#GO:0042176;negative regulation of catabolic process#GO:0009895;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434;cell communication#GO:0007154;organophosphate catabolic process#GO:0046434;negative regulation of protein metabolic process#GO:0051248;nucleoside phosphate metabolic process#GO:0006753;negative regulation of proteasomal protein catabolic process#GO:1901799;nucleoside phosphate catabolic process#GO:1901292;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;cellular response to stimulus#GO:0051716;cell death#GO:0008219;primary metabolic process#GO:0044238;programmed cell death#GO:0012501;negative regulation of ubiquitin-dependent protein catabolic process#GO:2000059;nucleobase-containing small molecule metabolic process#GO:0055086;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;metabolic process#GO:0008152;negative regulation of protein catabolic process#GO:0042177;regulation of proteasomal protein catabolic process#GO:0061136;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of protein metabolic process#GO:0051246;intrinsic apoptotic signaling pathway#GO:0097193;nucleotide metabolic process#GO:0009117;signal transduction by p53 class mediator#GO:0072331;signaling#GO:0023052;negative regulation of metabolic process#GO:0009892;negative regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032435;response to stimulus#GO:0050896;small molecule metabolic process#GO:0044281;intrinsic apoptotic signaling pathway by p53 class mediator#GO:0072332;purine-containing compound metabolic process#GO:0072521;apoptotic process#GO:0006915;purine nucleotide metabolic process#GO:0006163;regulation of biological process#GO:0050789;phosphorus metabolic process#GO:0006793;negative regulation of biological process#GO:0048519 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 phosphatase#PC00181;hydrolase#PC00121 HUMAN|HGNC=33847|UniProtKB=A6NJ69 A6NJ69 IGIP PTHR39224:SF1 IGA-INDUCING PROTEIN HOMOLOG IGA-INDUCING PROTEIN HOMOLOG HUMAN|HGNC=26991|UniProtKB=Q6IEE7 Q6IEE7 TMEM132E PTHR13388:SF7 DETONATOR, ISOFORM E TRANSMEMBRANE PROTEIN 132E epithelium development#GO:0060429;tissue development#GO:0009888;multicellular organismal process#GO:0032501;epithelial cell differentiation#GO:0030855;epidermal cell differentiation#GO:0009913;nervous system development#GO:0007399;hair cell differentiation#GO:0035315;sensory system development#GO:0048880;cellular process#GO:0009987;multicellular organism development#GO:0007275;animal organ development#GO:0048513;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;sensory organ development#GO:0007423;epidermis development#GO:0008544;neuron differentiation#GO:0030182;developmental process#GO:0032502;cell differentiation#GO:0030154;cell development#GO:0048468;anatomical structure development#GO:0048856;system development#GO:0048731;neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699 membrane#GO:0016020;cellular anatomical structure#GO:0110165 HUMAN|HGNC=21300|UniProtKB=Q9H633 Q9H633 RPP21 PTHR14742:SF0 RIBONUCLEASE P SUBUNIT P21 RIBONUCLEASE P PROTEIN SUBUNIT P21 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070 nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;endonuclease complex#GO:1905348;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;organelle lumen#GO:0043233;nucleolar ribonuclease P complex#GO:0005655;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;multimeric ribonuclease P complex#GO:0030681;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;ribonucleoprotein complex#GO:1990904;ribonuclease P complex#GO:0030677;endoribonuclease complex#GO:1902555;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 endoribonuclease#PC00094 HUMAN|HGNC=24001|UniProtKB=Q8NDC4 Q8NDC4 MORN4 PTHR46614:SF1 MORN REPEAT-CONTAINING PROTEIN 4 MORN REPEAT-CONTAINING PROTEIN 4 response to stress#GO:0006950;response to wounding#GO:0009611;response to stimulus#GO:0050896 cellular anatomical structure#GO:0110165;cell projection#GO:0042995 HUMAN|HGNC=9952|UniProtKB=P48304 P48304 REG1B PTHR22803:SF129 MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED LITHOSTATHINE-1-BETA growth factor activity#GO:0008083;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;hormone activity#GO:0005179;signaling receptor activator activity#GO:0030546 response to oxygen-containing compound#GO:1901700;immune system process#GO:0002376;response to nitrogen compound#GO:1901698;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;regulation of cell population proliferation#GO:0042127;regulation of biological process#GO:0050789;positive regulation of cell population proliferation#GO:0008284;response to endogenous stimulus#GO:0009719;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;humoral immune response#GO:0006959;antimicrobial humoral response#GO:0019730;defense response#GO:0006952;response to external stimulus#GO:0009605;positive regulation of biological process#GO:0048518;defense response to symbiont#GO:0140546;positive regulation of cellular process#GO:0048522;immune response#GO:0006955;response to hormone#GO:0009725;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;response to peptide hormone#GO:0043434;response to other organism#GO:0051707;biological regulation#GO:0065007;defense response to other organism#GO:0098542;response to chemical#GO:0042221 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=14962|UniProtKB=Q7L8C5 Q7L8C5 SYT13 PTHR10024:SF250 SYNAPTOTAGMIN SYNAPTOTAGMIN-13 protein binding#GO:0005515;molecular function regulator activity#GO:0098772;lipid binding#GO:0008289;molecular sensor activity#GO:0140299;SNARE binding#GO:0000149;binding#GO:0005488;phospholipid binding#GO:0005543 positive regulation of cellular process#GO:0048522;neurotransmitter secretion#GO:0007269;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;synaptic vesicle cycle#GO:0099504;transport#GO:0006810;establishment of localization#GO:0051234;signal release from synapse#GO:0099643;chemical synaptic transmission#GO:0007268;regulation of cell communication#GO:0010646;modulation of chemical synaptic transmission#GO:0050804;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;trans-synaptic signaling#GO:0099537;signal release#GO:0023061;regulation of exocytosis#GO:0017157;secretion#GO:0046903;regulation of secretion#GO:0051046;cell communication#GO:0007154;localization#GO:0051179;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;positive regulation of biological process#GO:0048518;synaptic vesicle exocytosis#GO:0016079;positive regulation of transport#GO:0051050;synaptic signaling#GO:0099536;neurotransmitter transport#GO:0006836;regulation of trans-synaptic signaling#GO:0099177;vesicle-mediated transport#GO:0016192;regulated exocytosis#GO:0045055;regulation of transport#GO:0051049;regulation of localization#GO:0032879;exocytosis#GO:0006887;positive regulation of vesicle fusion#GO:0031340;vesicle-mediated transport in synapse#GO:0099003;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;regulation of synaptic vesicle exocytosis#GO:2000300;export from cell#GO:0140352;signaling#GO:0023052;regulation of neurotransmitter secretion#GO:0046928;regulation of cellular component organization#GO:0051128;regulation of signaling#GO:0023051;positive regulation of cellular component organization#GO:0051130;regulation of neurotransmitter transport#GO:0051588;regulation of secretion by cell#GO:1903530;secretion by cell#GO:0032940;cellular localization#GO:0051641;positive regulation of organelle organization#GO:0010638 synaptic vesicle#GO:0008021;vesicle#GO:0031982;synaptic vesicle membrane#GO:0030672;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;axon#GO:0030424;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;membrane#GO:0016020;vesicle membrane#GO:0012506;cell periphery#GO:0071944;endomembrane system#GO:0012505;transport vesicle membrane#GO:0030658;transport vesicle#GO:0030133;plasma membrane#GO:0005886;organelle membrane#GO:0031090;intracellular vesicle#GO:0097708;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;cell projection#GO:0042995;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;secretory vesicle#GO:0099503;neuron projection#GO:0043005;presynapse#GO:0098793;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;cell junction#GO:0030054;bounding membrane of organelle#GO:0098588 membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=1482|UniProtKB=O15484 O15484 CAPN5 PTHR10183:SF402 CALPAIN CALPAIN-5 catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;cysteine-type endopeptidase activity#GO:0004197;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 primary metabolic process#GO:0044238;metabolic process#GO:0008152;proteolysis#GO:0006508;cellular process#GO:0009987;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protease#PC00190;cysteine protease#PC00081 Huntington disease#P00029>Calpain#P00788 HUMAN|HGNC=27266|UniProtKB=Q3SY77 Q3SY77 UGT3A2 PTHR48043:SF24 EG:EG0003.4 PROTEIN-RELATED UDP-GLYCOSYLTRANSFERASE 3A2 glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194;transferase activity#GO:0016740;catalytic activity#GO:0003824;glucuronosyltransferase activity#GO:0015020;hexosyltransferase activity#GO:0016758 endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;membrane#GO:0016020;endoplasmic reticulum protein-containing complex#GO:0140534;organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;transferase complex#GO:1990234;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;catalytic complex#GO:1902494 HUMAN|HGNC=20444|UniProtKB=Q9P267 Q9P267 MBD5 PTHR16112:SF18 METHYL-CPG BINDING PROTEIN, DROSOPHILA METHYL-CPG-BINDING DOMAIN PROTEIN 5 chromatin binding#GO:0003682;binding#GO:0005488 nucleus#GO:0005634;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=4818|UniProtKB=Q92839 Q92839 HAS1 PTHR22913:SF4 HYALURONAN SYNTHASE HYALURONAN SYNTHASE 1 catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758;glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194 extracellular matrix organization#GO:0030198;external encapsulating structure organization#GO:0045229;extracellular structure organization#GO:0043062;aminoglycan metabolic process#GO:0006022;polysaccharide biosynthetic process#GO:0000271;polysaccharide metabolic process#GO:0005976;carbohydrate metabolic process#GO:0005975;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;glycosaminoglycan metabolic process#GO:0030203;aminoglycan biosynthetic process#GO:0006023;carbohydrate derivative biosynthetic process#GO:1901137;cellular component organization or biogenesis#GO:0071840;glycosaminoglycan biosynthetic process#GO:0006024;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;extracellular matrix assembly#GO:0085029;cellular component assembly#GO:0022607;carbohydrate biosynthetic process#GO:0016051;biosynthetic process#GO:0009058;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transferase#PC00220;glycosyltransferase#PC00111 HUMAN|HGNC=17932|UniProtKB=Q9UHV2 Q9UHV2 SERTAD1 PTHR16277:SF12 CELL DIVISION CYCLE ASSOCIATED PROTEIN 4/SERTA DOMAIN-CONTAINING PROTEIN 2 SERTA DOMAIN-CONTAINING PROTEIN 1 transcription coactivator activity#GO:0003713;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 transcription cofactor#PC00217 HUMAN|HGNC=23354|UniProtKB=Q8ND76 Q8ND76 CCNY PTHR14248:SF33 CYCLIN Y, ISOFORM A CYCLIN-Y molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;kinase activator activity#GO:0019209;protein kinase regulator activity#GO:0019887;cyclin-dependent protein kinase regulator activity#GO:0019914;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;protein kinase activator activity#GO:0030295;protein serine/threonine kinase activator activity#GO:0043539;enzyme activator activity#GO:0008047;cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538 regulation of canonical Wnt signaling pathway#GO:0060828;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of Wnt signaling pathway#GO:0030111;regulation of cell communication#GO:0010646;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;transferase complex, transferring phosphorus-containing groups#GO:0061695;transferase complex#GO:1990234;catalytic complex#GO:1902494;protein kinase complex#GO:1902911;intracellular anatomical structure#GO:0005622;serine/threonine protein kinase complex#GO:1902554 HUMAN|HGNC=6125|UniProtKB=P35568 P35568 IRS1 PTHR10614:SF11 INSULIN RECEPTOR SUBSTRATE INSULIN RECEPTOR SUBSTRATE 1 receptor tyrosine kinase binding#GO:0030971;molecular adaptor activity#GO:0060090;signaling receptor complex adaptor activity#GO:0030159;transmembrane receptor protein tyrosine kinase adaptor activity#GO:0005068;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;protein-macromolecule adaptor activity#GO:0030674;binding#GO:0005488;signaling receptor binding#GO:0005102;protein tyrosine kinase binding#GO:1990782;kinase binding#GO:0019900;protein binding#GO:0005515;signaling adaptor activity#GO:0035591 cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;insulin-like growth factor receptor signaling pathway#GO:0048009;cellular response to hormone stimulus#GO:0032870;regulation of cellular process#GO:0050794;signaling#GO:0023052;cellular response to peptide hormone stimulus#GO:0071375;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to insulin#GO:0032868;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;response to nitrogen compound#GO:1901698;intracellular signal transduction#GO:0035556;cellular response to chemical stimulus#GO:0070887;response to oxygen-containing compound#GO:1901700;insulin receptor signaling pathway#GO:0008286;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;response to chemical#GO:0042221;cellular response to nitrogen compound#GO:1901699;biological regulation#GO:0065007;response to peptide hormone#GO:0043434;intracellular signaling cassette#GO:0141124;response to hormone#GO:0009725;phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0043491;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;cellular process#GO:0009987;cell surface receptor signaling pathway#GO:0007166;cellular response to insulin stimulus#GO:0032869 membrane#GO:0016020;cytosol#GO:0005829;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 Gonadotropin-releasing hormone receptor pathway#P06664>IRS-1#P06825;PI3 kinase pathway#P00048>IRS#P01193;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>IRS 1-4#P00899;CCKR signaling map#P06959>IRS1#P07106;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>IRS 1-4#P00887;Interleukin signaling pathway#P00036>IRS1/2#P00980;Gonadotropin-releasing hormone receptor pathway#P06664>IRS#P06759 HUMAN|HGNC=21700|UniProtKB=Q6WBX8 Q6WBX8 RAD9B PTHR15237:SF2 DNA REPAIR PROTEIN RAD9 CELL CYCLE CHECKPOINT CONTROL PROTEIN RAD9B DNA damage checkpoint signaling#GO:0000077;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;DNA integrity checkpoint signaling#GO:0031570;regulation of mitotic cell cycle#GO:0007346;mitotic DNA integrity checkpoint signaling#GO:0044774;response to radiation#GO:0009314;macromolecule metabolic process#GO:0043170;mitotic cell cycle process#GO:1903047;negative regulation of cellular process#GO:0048523;DNA repair#GO:0006281;negative regulation of cell cycle process#GO:0010948;DNA damage response#GO:0006974;regulation of cellular process#GO:0050794;cellular response to environmental stimulus#GO:0104004;mitotic cell cycle#GO:0000278;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of cell cycle phase transition#GO:1901987;mitotic cell cycle checkpoint signaling#GO:0007093;cell cycle#GO:0007049;mitotic DNA damage checkpoint signaling#GO:0044773;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cell cycle checkpoint signaling#GO:0000075;regulation of cell cycle process#GO:0010564;response to stress#GO:0006950;cellular process#GO:0009987;signal transduction#GO:0007165;cellular response to abiotic stimulus#GO:0071214;negative regulation of cell cycle#GO:0045786;DNA replication checkpoint signaling#GO:0000076;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;response to stimulus#GO:0050896;cellular response to radiation#GO:0071478;signaling#GO:0023052;regulation of cell cycle#GO:0051726;negative regulation of cell cycle phase transition#GO:1901988;response to abiotic stimulus#GO:0009628;negative regulation of biological process#GO:0048519;cell cycle process#GO:0022402;regulation of biological process#GO:0050789;signal transduction in response to DNA damage#GO:0042770;response to ionizing radiation#GO:0010212;mitotic intra-S DNA damage checkpoint signaling#GO:0031573;negative regulation of mitotic cell cycle#GO:0045930;cellular response to stress#GO:0033554 membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;condensed nuclear chromosome#GO:0000794;condensed chromosome#GO:0000793;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;chromosome#GO:0005694;organelle lumen#GO:0043233 exodeoxyribonuclease#PC00098 HUMAN|HGNC=10615|UniProtKB=Q92583 Q92583 CCL17 PTHR12015:SF111 SMALL INDUCIBLE CYTOKINE A C-C MOTIF CHEMOKINE 17 cytokine#PC00083 HUMAN|HGNC=9114|UniProtKB=Q92871 Q92871 PMM1 PTHR10466:SF1 PHOSPHOMANNOMUTASE PHOSPHOMANNOMUTASE 1 intramolecular transferase activity#GO:0016866;catalytic activity#GO:0003824;intramolecular phosphotransferase activity#GO:0016868;isomerase activity#GO:0016853 hexose metabolic process#GO:0019318;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487;small molecule metabolic process#GO:0044281;carbohydrate metabolic process#GO:0005975;protein metabolic process#GO:0019538;glycoprotein biosynthetic process#GO:0009101;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;biosynthetic process#GO:0009058;monosaccharide metabolic process#GO:0005996;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 mutase#PC00160;isomerase#PC00135;metabolite interconversion enzyme#PC00262 Mannose metabolism#P02752>P-Mannose mutase#P03019 HUMAN|HGNC=10420|UniProtKB=P23396 P23396 RPS3 PTHR11760:SF38 30S/40S RIBOSOMAL PROTEIN S3 SMALL RIBOSOMAL SUBUNIT PROTEIN US3 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 positive regulation of programmed cell death#GO:0043068;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;positive regulation of apoptotic signaling pathway#GO:2001235;regulation of cell communication#GO:0010646;positive regulation of signal transduction#GO:0009967;regulation of programmed cell death#GO:0043067;regulation of biological process#GO:0050789;positive regulation of signaling#GO:0023056;regulation of apoptotic signaling pathway#GO:2001233;regulation of signaling#GO:0023051;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of apoptotic process#GO:0043065;regulation of apoptotic process#GO:0042981;regulation of response to stimulus#GO:0048583 cytosolic ribosome#GO:0022626;ribosome#GO:0005840;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytosolic small ribosomal subunit#GO:0022627;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;small ribosomal subunit#GO:0015935;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;nucleus#GO:0005634;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228 ribosomal protein#PC00202 HUMAN|HGNC=870|UniProtKB=P35670 P35670 ATP7B PTHR43520:SF30 ATP7, ISOFORM B COPPER-TRANSPORTING ATPASE 2 transition metal ion transmembrane transporter activity#GO:0046915;binding#GO:0005488;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;metal ion binding#GO:0046872;monoatomic cation transmembrane transporter activity#GO:0008324;copper ion binding#GO:0005507;transporter activity#GO:0005215;P-type ion transporter activity#GO:0015662;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;ion binding#GO:0043167;small molecule binding#GO:0036094;transition metal ion binding#GO:0046914;cation binding#GO:0043169;transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;inorganic ion homeostasis#GO:0098771;transition metal ion transport#GO:0000041;metal ion transport#GO:0030001;homeostatic process#GO:0042592;copper ion transmembrane transport#GO:0035434;intracellular monoatomic ion homeostasis#GO:0006873;establishment of localization#GO:0051234;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;transport#GO:0006810;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;plasma membrane#GO:0005886;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;cell periphery#GO:0071944 primary active transporter#PC00068 HUMAN|HGNC=25806|UniProtKB=Q8NEC7 Q8NEC7 GSTCD PTHR13369:SF4 FAMILY NOT NAMED GLUTATHIONE S-TRANSFERASE C-TERMINAL DOMAIN-CONTAINING PROTEIN response to stimulus#GO:0050896;defense response#GO:0006952;response to stress#GO:0006950;inflammatory response#GO:0006954 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=9995|UniProtKB=O14921 O14921 RGS13 PTHR10845:SF32 REGULATOR OF G PROTEIN SIGNALING REGULATOR OF G PROTEIN SIGNALING 13 enzyme activator activity#GO:0008047;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695 negative regulation of signaling#GO:0023057;negative regulation of cellular process#GO:0048523;regulation of signaling#GO:0023051;regulation of G protein-coupled receptor signaling pathway#GO:0008277;regulation of response to stimulus#GO:0048583;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;negative regulation of G protein-coupled receptor signaling pathway#GO:0045744;regulation of biological process#GO:0050789;negative regulation of response to stimulus#GO:0048585;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;negative regulation of signal transduction#GO:0009968 membrane#GO:0016020;cytoplasmic side of plasma membrane#GO:0009898;cytoplasmic side of membrane#GO:0098562;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;plasma membrane#GO:0005886 GTPase-activating protein#PC00257 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>RGS#P00731;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>RGS#P00833;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>RGS#P00704 HUMAN|HGNC=23598|UniProtKB=Q6L8H2 Q6L8H2 KRTAP5-3 PTHR23262:SF254 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 5-3 structural protein#PC00211 HUMAN|HGNC=11316|UniProtKB=P05455 P05455 SSB PTHR22792:SF158 LUPUS LA PROTEIN-RELATED LUPUS LA PROTEIN RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;gene expression#GO:0010467;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 RNA metabolism protein#PC00031 HUMAN|HGNC=28764|UniProtKB=Q9BVV2 Q9BVV2 FNDC11 PTHR14537:SF0 FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN 11 FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN 11 HUMAN|HGNC=9323|UniProtKB=O00743 O00743 PPP6C PTHR45619:SF67 SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED SERINE_THREONINE-PROTEIN PHOSPHATASE 6 CATALYTIC SUBUNIT hydrolase activity#GO:0016787;protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096 cell cycle phase transition#GO:0044770;mitotic cell cycle#GO:0000278;cell cycle process#GO:0022402;cellular process#GO:0009987;cell cycle G1/S phase transition#GO:0044843;cell cycle#GO:0007049;mitotic cell cycle process#GO:1903047;G1/S transition of mitotic cell cycle#GO:0000082;mitotic cell cycle phase transition#GO:0044772 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;protein phosphatase#PC00195 EGF receptor signaling pathway#P00018>PP2A#P00547 HUMAN|HGNC=23014|UniProtKB=Q8NBI2 Q8NBI2 CYB561A3 PTHR10106:SF38 CYTOCHROME B561-RELATED LYSOSOMAL MEMBRANE ASCORBATE-DEPENDENT FERRIREDUCTASE CYB561A3 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;catalytic activity#GO:0003824;oxidoreductase activity, acting on metal ions#GO:0016722;active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399;oxidoreductase activity#GO:0016491 inorganic ion homeostasis#GO:0098771;intracellular monoatomic cation homeostasis#GO:0030003;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion homeostasis#GO:0050801;carbohydrate homeostasis#GO:0033500;intracellular iron ion homeostasis#GO:0006879;homeostatic process#GO:0042592 vacuole#GO:0005773;cytoplasm#GO:0005737;lysosomal membrane#GO:0005765;membrane#GO:0016020;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;lytic vacuole#GO:0000323;vacuolar membrane#GO:0005774;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;lysosome#GO:0005764;lytic vacuole membrane#GO:0098852;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 reductase#PC00198;oxidoreductase#PC00176 HUMAN|HGNC=7884|UniProtKB=Q99466 Q99466 NOTCH4 PTHR24044:SF489 NOTCH LIGAND FAMILY MEMBER NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4 protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 cell communication#GO:0007154;negative regulation of cell communication#GO:0010648;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;regulation of Notch signaling pathway#GO:0008593;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of cell communication#GO:0010646;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;Notch signaling pathway#GO:0007219;negative regulation of cellular process#GO:0048523;negative regulation of Notch signaling pathway#GO:0045746;cell surface receptor signaling pathway#GO:0007166;regulation of response to stimulus#GO:0048583;negative regulation of response to stimulus#GO:0048585;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;signal transduction#GO:0007165;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 intercellular signal molecule#PC00207 Notch signaling pathway#P00045>NIct#P01119;Angiogenesis#P00005>Notch#P00255;Notch signaling pathway#P00045>Notch#P01099;Alzheimer disease-presenilin pathway#P00004>NICD#P00122;Alzheimer disease-presenilin pathway#P00004>Notch extracellular fragment#P00179;Alzheimer disease-presenilin pathway#P00004>Notch transmembrane fragment#P00135;Alzheimer disease-presenilin pathway#P00004>Notch C-terminal fragment#P00120;Alzheimer disease-presenilin pathway#P00004>Notch fragment#P00154;Alzheimer disease-presenilin pathway#P00004>Notch#P00176;Notch signaling pathway#P00045>Ntm#P01114;Notch signaling pathway#P00045>NIcs#P01120;Alzheimer disease-presenilin pathway#P00004>Notch N-terminal fragment#P00171 HUMAN|HGNC=8244|UniProtKB=Q9H210 Q9H210 OR2D2 PTHR26453:SF156 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2D2 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 detection of chemical stimulus#GO:0009593;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;response to stimulus#GO:0050896;response to chemical#GO:0042221;nervous system process#GO:0050877;sensory perception#GO:0007600;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=11332|UniProtKB=P32745 P32745 SSTR3 PTHR24229:SF42 NEUROPEPTIDES RECEPTOR SOMATOSTATIN RECEPTOR TYPE 3 binding#GO:0005488;peptide binding#GO:0042277;neuropeptide binding#GO:0042923;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023 biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;neuropeptide signaling pathway#GO:0007218;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GoPCR#P00725;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GsPCR#P00720 HUMAN|HGNC=1817|UniProtKB=P06731 P06731 CEACAM5 PTHR44337:SF20 CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 8 CELL ADHESION MOLECULE CEACAM5-RELATED cell adhesion#GO:0007155;cellular process#GO:0009987;heterophilic cell-cell adhesion#GO:0007157;homophilic cell-cell adhesion#GO:0007156;cell-cell adhesion#GO:0098609 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 immunoglobulin superfamily cell adhesion molecule#PC00125;cell adhesion molecule#PC00069 HUMAN|HGNC=30758|UniProtKB=Q8NDF8 Q8NDF8 TENT4B PTHR23092:SF51 POLY(A) RNA POLYMERASE TERMINAL NUCLEOTIDYLTRANSFERASE 4B transferase activity, transferring phosphorus-containing groups#GO:0016772;adenylyltransferase activity#GO:0070566;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779 nucleobase-containing compound catabolic process#GO:0034655;macromolecule biosynthetic process#GO:0009059;nucleic acid catabolic process#GO:0141188;cellular process#GO:0009987;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;RNA 3'-end processing#GO:0031123;macromolecule metabolic process#GO:0043170;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;catabolic process#GO:0009056;RNA biosynthetic process#GO:0032774;modification-dependent macromolecule catabolic process#GO:0043632;nucleic acid biosynthetic process#GO:0141187;RNA catabolic process#GO:0006401;RNA metabolic process#GO:0016070 nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165 mRNA polyadenylation factor#PC00146 HUMAN|HGNC=4542|UniProtKB=Q9BXA5 Q9BXA5 SUCNR1 PTHR24231:SF14 PURINOCEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR SUCCINATE RECEPTOR 1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=288|UniProtKB=P13945 P13945 ADRB3 PTHR24248:SF3 ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR BETA-3 ADRENERGIC RECEPTOR small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;cation binding#GO:0043169;hormone binding#GO:0042562;G protein-coupled amine receptor activity#GO:0008227;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023 system process#GO:0003008;regulation of anatomical structure size#GO:0090066;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;multicellular organismal process#GO:0032501;blood circulation#GO:0008015;biological regulation#GO:0065007;regulation of systemic arterial blood pressure#GO:0003073;regulation of blood pressure#GO:0008217;cellular process#GO:0009987;signal transduction#GO:0007165;cell communication#GO:0007154;adrenergic receptor signaling pathway#GO:0071875;regulation of biological quality#GO:0065008;circulatory system process#GO:0003013;G protein-coupled receptor signaling pathway#GO:0007186;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;vasodilation#GO:0042311;signaling#GO:0023052;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GsPCR#P00720;Beta3 adrenergic receptor signaling pathway#P04379>Beta3#P04449 HUMAN|HGNC=16788|UniProtKB=Q9BZQ2 Q9BZQ2 SHCBP1L PTHR14695:SF7 SHC SH2-DOMAIN BINDING PROTEIN 1-RELATED TESTICULAR SPINDLE-ASSOCIATED PROTEIN SHCBP1L organelle organization#GO:0006996;cellular process#GO:0009987;male gamete generation#GO:0048232;male meiotic nuclear division#GO:0007140;meiotic cell cycle#GO:0051321;developmental process#GO:0032502;spermatogenesis#GO:0007283;meiotic nuclear division#GO:0140013;cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;meiotic cell cycle process#GO:1903046;developmental process involved in reproduction#GO:0003006;cell cycle#GO:0007049;cell division#GO:0051301;cell cycle process#GO:0022402;gamete generation#GO:0007276;reproductive process#GO:0022414;nuclear division#GO:0000280;cytokinesis#GO:0000910;sexual reproduction#GO:0019953;organelle fission#GO:0048285;cytoskeleton-dependent cytokinesis#GO:0061640;multicellular organismal reproductive process#GO:0048609 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;spindle#GO:0005819;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630 HUMAN|HGNC=20630|UniProtKB=Q96IQ9 Q96IQ9 ZNF414 PTHR21695:SF0 ZINC FINGER PROTEIN 414 ZINC FINGER PROTEIN 414 HUMAN|HGNC=10675|UniProtKB=Q99470 Q99470 SDF2 PTHR46809:SF3 STROMAL CELL-DERIVED FACTOR 2-LIKE PROTEIN STROMAL CELL-DERIVED FACTOR 2 HUMAN|HGNC=23473|UniProtKB=Q5W0B7 Q5W0B7 TMEM236 PTHR31453:SF2 TRANSMEMBRANE PROTEIN 236 TRANSMEMBRANE PROTEIN 236 HUMAN|HGNC=20813|UniProtKB=Q9H4T2 Q9H4T2 ZSCAN16 PTHR23226:SF52 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 16 RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=6131|UniProtKB=Q00978 Q00978 IRF9 PTHR11949:SF26 INTERFERON REGULATORY FACTOR INTERFERON REGULATORY FACTOR 9 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 DNA-binding transcription factor#PC00218;winged helix/forkhead transcription factor#PC00246 HUMAN|HGNC=10590|UniProtKB=Q9NY46 Q9NY46 SCN3A PTHR10037:SF237 VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM SODIUM CHANNEL PROTEIN TYPE 3 SUBUNIT ALPHA channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;sodium channel activity#GO:0005272;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;metal ion transmembrane transporter activity#GO:0046873;voltage-gated sodium channel activity#GO:0005248;sodium ion transmembrane transporter activity#GO:0015081;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic cation channel activity#GO:0005261 cell communication#GO:0007154;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;sensory perception#GO:0007600;nervous system process#GO:0050877;membrane depolarization#GO:0051899;metal ion transport#GO:0030001;sensory perception of pain#GO:0019233;action potential#GO:0001508;sodium ion transport#GO:0006814;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;transmission of nerve impulse#GO:0019226;system process#GO:0003008;transport#GO:0006810;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987 axon#GO:0030424;sodium channel complex#GO:0034706;transmembrane transporter complex#GO:1902495;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;cation channel complex#GO:0034703;transporter complex#GO:1990351;cell periphery#GO:0071944;neuron projection#GO:0043005;membrane#GO:0016020;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702 voltage-gated ion channel#PC00241 HUMAN|HGNC=11071|UniProtKB=P19634 P19634 SLC9A1 PTHR10110:SF59 SODIUM/HYDROGEN EXCHANGER SODIUM_HYDROGEN EXCHANGER 1 potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;antiporter activity#GO:0015297;proton transmembrane transporter activity#GO:0015078;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;monoatomic ion transmembrane transporter activity#GO:0015075;metal cation:proton antiporter activity#GO:0051139;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081 potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;biological regulation#GO:0065007;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;import into cell#GO:0098657;establishment of localization#GO:0051234;cellular homeostasis#GO:0019725;inorganic cation import across plasma membrane#GO:0098659;intracellular chemical homeostasis#GO:0055082;monoatomic cation homeostasis#GO:0055080;transport#GO:0006810;intracellular monoatomic cation homeostasis#GO:0030003;chemical homeostasis#GO:0048878;import across plasma membrane#GO:0098739;inorganic ion import across plasma membrane#GO:0099587;metal ion transport#GO:0030001;homeostatic process#GO:0042592;intracellular monoatomic ion homeostasis#GO:0006873;sodium ion transport#GO:0006814;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;regulation of pH#GO:0006885;regulation of intracellular pH#GO:0051453 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 secondary carrier transporter#PC00258 HUMAN|HGNC=10911|UniProtKB=P55011 P55011 SLC12A2 PTHR11827:SF58 SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS SOLUTE CARRIER FAMILY 12 MEMBER 2 symporter activity#GO:0015293;monoatomic cation transmembrane transporter activity#GO:0008324;potassium ion transmembrane transporter activity#GO:0015079;solute:sodium symporter activity#GO:0015370;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;monoatomic anion transmembrane transporter activity#GO:0008509;chloride transmembrane transporter activity#GO:0015108;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294 monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;inorganic anion transport#GO:0015698;monoatomic ion transport#GO:0006811;metal ion transport#GO:0030001;monoatomic anion transport#GO:0006820;sodium ion transport#GO:0006814;establishment of localization#GO:0051234;chloride transport#GO:0006821;transport#GO:0006810;potassium ion transport#GO:0006813;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;monoatomic ion transmembrane transport#GO:0034220;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987 cell projection#GO:0042995;plasma membrane#GO:0005886;neuronal cell body#GO:0043025;somatodendritic compartment#GO:0036477;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;cell body#GO:0044297;cell periphery#GO:0071944;apical plasma membrane#GO:0016324;membrane#GO:0016020;apical part of cell#GO:0045177 secondary carrier transporter#PC00258 HUMAN|HGNC=15522|UniProtKB=Q9NS61 Q9NS61 KCNIP2 PTHR23055:SF65 CALCIUM BINDING PROTEINS A-TYPE POTASSIUM CHANNEL MODULATORY PROTEIN KCNIP2 small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;transporter regulator activity#GO:0141108;potassium channel regulator activity#GO:0015459;calcium ion binding#GO:0005509;metal ion binding#GO:0046872;channel regulator activity#GO:0016247;cation binding#GO:0043169;ion channel regulator activity#GO:0099106;molecular function regulator activity#GO:0098772 regulation of transport#GO:0051049;regulation of localization#GO:0032879;regulation of monoatomic cation transmembrane transport#GO:1904062;biological regulation#GO:0065007;regulation of monoatomic ion transport#GO:0043269;regulation of metal ion transport#GO:0010959;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of monoatomic ion transmembrane transport#GO:0034765;regulation of transmembrane transport#GO:0034762 transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;cation channel complex#GO:0034703;voltage-gated potassium channel complex#GO:0008076;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944 calmodulin-related#PC00061 HUMAN|HGNC=21710|UniProtKB=Q6ZT07 Q6ZT07 TBC1D9 PTHR22957:SF536 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN TBC1 DOMAIN FAMILY MEMBER 9 enzyme activator activity#GO:0008047;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772 GTPase-activating protein#PC00257;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HUMAN|HGNC=33160|UniProtKB=P0C7L1 P0C7L1 SPINK8 PTHR21312:SF37 SERINE PROTEASE INHIBITOR SERINE PROTEASE INHIBITOR KAZAL-TYPE 8 protease inhibitor#PC00191;protein-binding activity modulator#PC00095 HUMAN|HGNC=17796|UniProtKB=Q9C0E2 Q9C0E2 XPO4 PTHR12596:SF1 EXPORTIN 4,7-RELATED EXPORTIN-4 nucleocytoplasmic carrier activity#GO:0140142;molecular carrier activity#GO:0140104 intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907;protein export from nucleus#GO:0006611;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;macromolecule localization#GO:0033036;nuclear export#GO:0051168;protein transport#GO:0015031;nuclear transport#GO:0051169;cellular localization#GO:0051641;localization#GO:0051179;nucleocytoplasmic transport#GO:0006913 organelle envelope#GO:0031967;nucleus#GO:0005634;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;nuclear pore#GO:0005643;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 transporter#PC00227 HUMAN|HGNC=16838|UniProtKB=Q9NW07 Q9NW07 ZNF358 PTHR24390:SF167 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 358 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 DNA-binding transcription factor#PC00218;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=20564|UniProtKB=Q9NUK0 Q9NUK0 MBNL3 PTHR12675:SF3 MUSCLEBLIND-LIKE PROTEIN MUSCLEBLIND-LIKE PROTEIN 3 nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of RNA splicing#GO:0043484;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 RNA processing factor#PC00147;RNA splicing factor#PC00148 HUMAN|HGNC=2040|UniProtKB=Q8N6F1 Q8N6F1 CLDN19 PTHR12002:SF27 CLAUDIN CLAUDIN-19 binding#GO:0005488;cell adhesion mediator activity#GO:0098631;cell adhesion molecule binding#GO:0050839;paracellular tight junction channel activity#GO:0160187;transporter activity#GO:0005215;protein binding#GO:0005515;cell-cell adhesion mediator activity#GO:0098632 cellular process#GO:0009987;sensory system development#GO:0048880;cellular component biogenesis#GO:0044085;retina development in camera-type eye#GO:0060041;tissue development#GO:0009888;multicellular organismal process#GO:0032501;epithelium development#GO:0060429;cellular component assembly#GO:0022607;cell-cell junction assembly#GO:0007043;transport#GO:0006810;developmental process#GO:0032502;cell-cell junction organization#GO:0045216;sensory organ development#GO:0007423;establishment of localization#GO:0051234;animal organ development#GO:0048513;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;paracellular transport#GO:0160184;cellular component organization#GO:0016043;cell junction assembly#GO:0034329;visual system development#GO:0150063;cell junction organization#GO:0034330;animal gross anatomical part developmental process#GO:0160108;camera-type eye development#GO:0043010;eye development#GO:0001654;system development#GO:0048731;anatomical structure development#GO:0048856;localization#GO:0051179 apical junction complex#GO:0043296;cell junction#GO:0030054;tight junction#GO:0070160;anchoring junction#GO:0070161;membrane#GO:0016020;cell-cell junction#GO:0005911;cell periphery#GO:0071944;bicellular tight junction#GO:0005923;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 tight junction#PC00214;cell junction protein#PC00070 HUMAN|HGNC=28029|UniProtKB=Q49AJ0 Q49AJ0 FAM135B PTHR12482:SF3 LIPASE ROG1-RELATED-RELATED PROTEIN FAM135B catalytic activity#GO:0003824;lipase activity#GO:0016298;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787 cellular process#GO:0009987;lipid metabolic process#GO:0006629;primary metabolic process#GO:0044238;metabolic process#GO:0008152 HUMAN|HGNC=28115|UniProtKB=Q5QJ74 Q5QJ74 TBCEL PTHR15140:SF69 TUBULIN-SPECIFIC CHAPERONE E TUBULIN-SPECIFIC CHAPERONE COFACTOR E-LIKE PROTEIN binding#GO:0005488;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515 microtubule-based process#GO:0007017;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular component organization#GO:0016043 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 chaperone#PC00072 HUMAN|HGNC=30247|UniProtKB=Q9Y6I9 Q9Y6I9 TEX264 PTHR15949:SF3 TESTIS-EXPRESSED PROTEIN 264 TESTIS-EXPRESSED PROTEIN 264 macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;nucleobase-containing compound metabolic process#GO:0006139;macroautophagy#GO:0016236;autophagy#GO:0006914;cellular process#GO:0009987;reticulophagy#GO:0061709;response to stress#GO:0006950;process utilizing autophagic mechanism#GO:0061919;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;catabolic process#GO:0009056;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 replication fork#GO:0005657;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;autophagosome#GO:0005776;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;autophagosome membrane#GO:0000421;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;membrane#GO:0016020;vacuole#GO:0005773;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;endomembrane system#GO:0012505;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;vacuolar membrane#GO:0005774;membraneless organelle#GO:0043228 HUMAN|HGNC=1995|UniProtKB=P12532 P12532 CKMT1A PTHR11547:SF24 ARGININE OR CREATINE KINASE CREATINE KINASE U-TYPE, MITOCHONDRIAL transferase activity#GO:0016740;catalytic activity#GO:0003824;phosphotransferase activity, nitrogenous group as acceptor#GO:0016775;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 biosynthetic process#GO:0009058;organophosphate biosynthetic process#GO:0090407;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;metabolic process#GO:0008152;modified amino acid metabolic process#GO:0006575;phosphorus metabolic process#GO:0006793 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;extracellular region#GO:0005576 amino acid kinase#PC00045;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=23643|UniProtKB=Q8IVF6 Q8IVF6 ANKRD18A PTHR24147:SF22 ANKYRIN REPEAT DOMAIN 36-RELATED ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 18A HUMAN|HGNC=1963|UniProtKB=Q05901 Q05901 CHRNB3 PTHR18945:SF75 NEUROTRANSMITTER GATED ION CHANNEL NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-3 gated channel activity#GO:0022836;postsynaptic neurotransmitter receptor activity#GO:0098960;transmembrane signaling receptor activity#GO:0004888;acetylcholine receptor activity#GO:0015464;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;neurotransmitter receptor activity#GO:0030594;signaling receptor activity#GO:0038023;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;ligand-gated monoatomic ion channel activity#GO:0015276;channel activity#GO:0015267;molecular transducer activity#GO:0060089;ligand-gated monoatomic cation channel activity#GO:0099094;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;transmembrane transporter activity#GO:0022857;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315 neuromuscular synaptic transmission#GO:0007274;regulation of membrane potential#GO:0042391;calcium ion transport#GO:0006816;synaptic signaling#GO:0099536;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987;response to chemical#GO:0042221;regulation of trans-synaptic signaling#GO:0099177;cellular response to chemical stimulus#GO:0070887;response to oxygen-containing compound#GO:1901700;regulation of signaling#GO:0023051;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signaling#GO:0023052;transport#GO:0006810;establishment of localization#GO:0051234;synaptic transmission, cholinergic#GO:0007271;cellular response to nitrogen compound#GO:1901699;acetylcholine receptor signaling pathway#GO:0095500;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;monoatomic ion transmembrane transport#GO:0034220;trans-synaptic signaling#GO:0099537;localization#GO:0051179;cell communication#GO:0007154;monoatomic cation transport#GO:0006812;response to nitrogen compound#GO:1901698;chemical synaptic transmission#GO:0007268;cellular response to stimulus#GO:0051716;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;modulation of chemical synaptic transmission#GO:0050804;membrane depolarization#GO:0051899;metal ion transport#GO:0030001;regulation of cell communication#GO:0010646 postsynapse#GO:0098794;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;synapse#GO:0045202;cellular anatomical structure#GO:0110165;postsynaptic membrane#GO:0045211;transmembrane transporter complex#GO:1902495;membrane#GO:0016020;cell periphery#GO:0071944;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane region#GO:0098590;plasma membrane#GO:0005886;signaling receptor complex#GO:0043235;synaptic membrane#GO:0097060;transporter complex#GO:1990351;cell junction#GO:0030054 ligand-gated ion channel#PC00141 Nicotinic acetylcholine receptor signaling pathway#P00044>alpha#P01088;Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086;Nicotine pharmacodynamics pathway#P06587>CHRNB3#P06612 HUMAN|HGNC=8778|UniProtKB=Q14432 Q14432 PDE3A PTHR11347:SF104 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE PHOSPHODIESTERASE hydrolase activity#GO:0016787;phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578;cyclic-nucleotide phosphodiesterase activity#GO:0004112;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788 negative regulation of cellular process#GO:0048523;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of response to stimulus#GO:0048585;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 hydrolase#PC00121;phosphodiesterase#PC00185 HUMAN|HGNC=16980|UniProtKB=Q02985 Q02985 CFHR3 PTHR45785:SF4 COMPLEMENT FACTOR H-RELATED COMPLEMENT FACTOR H-RELATED PROTEIN 3-RELATED protein binding#GO:0005515;complement binding#GO:0001848;binding#GO:0005488 regulation of biological process#GO:0050789;regulation of immune system process#GO:0002682;response to stimulus#GO:0050896;regulation of immune response#GO:0050776;immune system process#GO:0002376;positive regulation of biological process#GO:0048518;complement activation#GO:0006956;immune response#GO:0006955;activation of immune response#GO:0002253;positive regulation of immune system process#GO:0002684;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;immune effector process#GO:0002252;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;humoral immune response#GO:0006959 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 complement component#PC00078 HUMAN|HGNC=28583|UniProtKB=Q6UXX9 Q6UXX9 RSPO2 PTHR46987:SF4 NEUROHYPOPHYSIAL HORMONES, N-TERMINAL DOMAIN CONTAINING PROTEIN R-SPONDIN-2 binding#GO:0005488;signaling receptor binding#GO:0005102;receptor serine/threonine kinase binding#GO:0033612;protein binding#GO:0005515 biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of response to stimulus#GO:0048584;positive regulation of Wnt signaling pathway#GO:0030177;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of canonical Wnt signaling pathway#GO:0060828;positive regulation of canonical Wnt signaling pathway#GO:0090263;regulation of response to stimulus#GO:0048583;regulation of Wnt signaling pathway#GO:0030111;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=17450|UniProtKB=Q9HB55 Q9HB55 CYP3A43 PTHR24302:SF6 CYTOCHROME P450 FAMILY 3 CYTOCHROME P450 3A43 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen#GO:0016712;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;monooxygenase activity#GO:0004497;catalytic activity#GO:0003824;steroid hydroxylase activity#GO:0008395 lipid metabolic process#GO:0006629;cellular process#GO:0009987;metabolic process#GO:0008152;primary metabolic process#GO:0044238;steroid metabolic process#GO:0008202 oxygenase#PC00177;oxidoreductase#PC00176 HUMAN|HGNC=2434|UniProtKB=P04141 P04141 CSF2 PTHR10059:SF0 GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR GM-CSF GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677;signaling receptor regulator activity#GO:0030545;cytokine activity#GO:0005125;receptor ligand activity#GO:0048018 anatomical structure development#GO:0048856;cellular developmental process#GO:0048869;developmental process#GO:0032502;myeloid cell differentiation#GO:0030099;cell differentiation#GO:0030154;cell development#GO:0048468;hemopoiesis#GO:0030097;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 cytokine#PC00083 HUMAN|HGNC=42950|UniProtKB=E5RJM6 E5RJM6 ANKRD65 PTHR24166:SF52 ROLLING PEBBLES, ISOFORM B ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 65 scaffold/adaptor protein#PC00226 HUMAN|HGNC=6324|UniProtKB=P33176 P33176 KIF5B PTHR24115:SF513 KINESIN-RELATED KINESIN-1 HEAVY CHAIN ATP-dependent activity#GO:0140657;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;protein binding#GO:0005515;plus-end-directed microtubule motor activity#GO:0008574;hydrolase activity, acting on acid anhydrides#GO:0016817;cytoskeletal protein binding#GO:0008092;cytoskeletal motor activity#GO:0003774;microtubule binding#GO:0008017;polypeptide conformation or assembly isomerase activity#GO:0120544;ATP hydrolysis activity#GO:0016887;microtubule motor activity#GO:0003777;hydrolase activity#GO:0016787;macromolecular conformation isomerase activity#GO:0120543;tubulin binding#GO:0015631;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;isomerase activity#GO:0016853 establishment of localization#GO:0051234;transport along microtubule#GO:0010970;vesicle cytoskeletal trafficking#GO:0099518;mitochondrion localization#GO:0051646;microtubule-based process#GO:0007017;vesicle transport along microtubule#GO:0047496;intracellular transport#GO:0046907;transport#GO:0006810;cytoskeleton-dependent intracellular transport#GO:0030705;synaptic vesicle localization#GO:0097479;establishment of vesicle localization#GO:0051650;organelle transport along microtubule#GO:0072384;synaptic vesicle transport#GO:0048489;axo-dendritic transport#GO:0008088;vesicle localization#GO:0051648;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;localization#GO:0051179;cellular localization#GO:0051641;anterograde axonal transport#GO:0008089;axonal transport#GO:0098930;organelle localization#GO:0051640;microtubule-based transport#GO:0099111;microtubule-based movement#GO:0007018;establishment of organelle localization#GO:0051656 microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;supramolecular polymer#GO:0099081;cytoskeleton#GO:0005856;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874 microtubule or microtubule-binding cytoskeletal protein#PC00157;microtubule binding motor protein#PC00156 HUMAN|HGNC=12872|UniProtKB=Q15915 Q15915 ZIC1 PTHR19818:SF141 ZINC FINGER PROTEIN ZIC AND GLI ZINC FINGER PROTEIN ZIC 1 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;nervous system development#GO:0007399;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biosynthetic process#GO:0009889;multicellular organism development#GO:0007275;regulation of gene expression#GO:0010468;developmental process#GO:0032502;regulation of cellular process#GO:0050794;central nervous system development#GO:0007417;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=20866|UniProtKB=Q9BXY4 Q9BXY4 RSPO3 PTHR46987:SF1 NEUROHYPOPHYSIAL HORMONES, N-TERMINAL DOMAIN CONTAINING PROTEIN R-SPONDIN-3 G protein-coupled receptor binding#GO:0001664;frizzled binding#GO:0005109;signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515 positive regulation of canonical Wnt signaling pathway#GO:0090263;regulation of response to stimulus#GO:0048583;positive regulation of Wnt signaling pathway#GO:0030177;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of canonical Wnt signaling pathway#GO:0060828;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of Wnt signaling pathway#GO:0030111;regulation of cell communication#GO:0010646;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=690|UniProtKB=O95376 O95376 ARIH2 PTHR11685:SF210 RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING E3 UBIQUITIN-PROTEIN LIGASE ARIH2 transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;binding#GO:0005488;ubiquitin-like protein transferase activity#GO:0019787;enzyme binding#GO:0019899;ubiquitin protein ligase activity#GO:0061630;protein binding#GO:0005515;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842 metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;catabolic process#GO:0009056 ubiquitin ligase complex#GO:0000151;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;transferase complex#GO:1990234;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=30524|UniProtKB=P0C7W6 P0C7W6 CCDC172 PTHR22419:SF2 COILED-COIL DOMAIN-CONTAINING PROTEIN 172 COILED-COIL DOMAIN-CONTAINING PROTEIN 172 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=10522|UniProtKB=Q53FZ2 Q53FZ2 ACSM3 PTHR43605:SF7 ACYL-COENZYME A SYNTHETASE ACYL-COENZYME A SYNTHETASE ACSM3, MITOCHONDRIAL acyltransferase activity#GO:0016746;ligase activity, forming carbon-sulfur bonds#GO:0016877;catalytic activity#GO:0003824;transferase activity#GO:0016740;ATP-dependent activity#GO:0140657;ligase activity#GO:0016874;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;purine-containing compound metabolic process#GO:0072521;carboxylic acid biosynthetic process#GO:0046394;oxoacid metabolic process#GO:0043436;lipid biosynthetic process#GO:0008610;fatty acid biosynthetic process#GO:0006633;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;sulfur compound metabolic process#GO:0006790;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;monocarboxylic acid biosynthetic process#GO:0072330;nucleobase-containing small molecule metabolic process#GO:0055086;acyl-CoA metabolic process#GO:0006637;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283 intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;ligase#PC00142 HUMAN|HGNC=9666|UniProtKB=P08575 P08575 PTPRC PTHR19134:SF539 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoprotein phosphatase activity#GO:0004721;protein tyrosine phosphatase activity#GO:0004725;hydrolase activity#GO:0016787 signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154 protein phosphatase#PC00195;protein modifying enzyme#PC00260 T cell activation#P00053>CD45#P01329;B cell activation#P00010>CD45#P00396;JAK/STAT signaling pathway#P00038>PTP#P01033 HUMAN|HGNC=14173|UniProtKB=Q9UJJ7 Q9UJJ7 RPUSD1 PTHR21600:SF94 MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE PSEUDOURIDYLATE SYNTHASE RPUSD1 intramolecular transferase activity#GO:0016866;catalytic activity#GO:0003824;isomerase activity#GO:0016853 ribosome biogenesis#GO:0042254;RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;rRNA processing#GO:0006364;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;pseudouridine synthesis#GO:0001522;rRNA modification#GO:0000154;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139 RNA processing factor#PC00147 HUMAN|HGNC=21106|UniProtKB=A1A5C7 A1A5C7 SLC22A23 PTHR24064:SF192 SOLUTE CARRIER FAMILY 22 MEMBER SOLUTE CARRIER FAMILY 22 MEMBER 23 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 secondary carrier transporter#PC00258 HUMAN|HGNC=15246|UniProtKB=Q8NGI1 Q8NGI1 OR56B2 PTHR26450:SF26 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 56B2 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=29077|UniProtKB=Q96RY7 Q96RY7 IFT140 PTHR15722:SF7 IFT140/172-RELATED INTRAFLAGELLAR TRANSPORT PROTEIN 140 HOMOLOG microtubule-based transport#GO:0099111;cilium organization#GO:0044782;cellular localization#GO:0051641;localization#GO:0051179;cellular component organization#GO:0016043;intraciliary transport#GO:0042073;microtubule-based movement#GO:0007018;intraciliary retrograde transport#GO:0035721;cell projection organization#GO:0030030;transport#GO:0006810;intracellular transport#GO:0046907;microtubule-based process#GO:0007017;transport along microtubule#GO:0010970;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;organelle organization#GO:0006996;plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton-dependent intracellular transport#GO:0030705 membraneless organelle#GO:0043228;intraciliary transport particle A#GO:0030991;cytoskeleton#GO:0005856;ciliary basal body#GO:0036064;microtubule organizing center#GO:0005815;protein-containing complex#GO:0032991;ciliary plasm#GO:0097014;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;axoneme#GO:0005930;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intraciliary transport particle#GO:0030990;intracellular organelle#GO:0043229;cilium#GO:0005929;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995 structural protein#PC00211 HUMAN|HGNC=28628|UniProtKB=Q8N5I9 Q8N5I9 NOPCHAP1 PTHR28674:SF1 SIMILAR TO DNA SEGMENT, CHR 10, WAYNE STATE UNIVERSITY 102,-EXPRESSED NOP PROTEIN CHAPERONE 1 protein-containing complex binding#GO:0044877;ribonucleoprotein complex binding#GO:0043021;binding#GO:0005488 ribonucleoprotein complex biogenesis#GO:0022613;cellular component assembly#GO:0022607;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;protein-RNA complex organization#GO:0071826;protein-RNA complex assembly#GO:0022618 HUMAN|HGNC=7980|UniProtKB=P22736 P22736 NR4A1 PTHR24085:SF1 NUCLEAR HORMONE RECEPTOR NUCLEAR RECEPTOR SUBFAMILY 4IMMUNITYGROUP A MEMBER 1 sequence-specific double-stranded DNA binding#GO:1990837;transcription factor binding#GO:0008134;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;sequence-specific DNA binding#GO:0043565;nuclear receptor binding#GO:0016922;DNA-binding transcription factor binding#GO:0140297;protein binding#GO:0005515;RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629;transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700 regulation of DNA-templated transcription#GO:0006355;response to nitrogen compound#GO:1901698;regulation of RNA metabolic process#GO:0051252;cellular response to chemical stimulus#GO:0070887;response to oxygen-containing compound#GO:1901700;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;cellular response to hormone stimulus#GO:0032870;cellular response to peptide hormone stimulus#GO:0071375;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;response to chemical#GO:0042221;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular response to nitrogen compound#GO:1901699;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;response to peptide hormone#GO:0043434;regulation of primary metabolic process#GO:0080090;response to hormone#GO:0009725;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667 DNA-binding transcription factor#PC00218;C4 zinc finger nuclear receptor#PC00169 CCKR signaling map#P06959>NR4A1#G07289;Gonadotropin-releasing hormone receptor pathway#P06664>Nur77#P06713;Gonadotropin-releasing hormone receptor pathway#P06664>Nur77#G06679;Gonadotropin-releasing hormone receptor pathway#P06664>Nur77#G06893;CCKR signaling map#P06959>NR4A1#G06995 HUMAN|HGNC=18154|UniProtKB=Q9Y4L5 Q9Y4L5 RNF115 PTHR15710:SF16 E3 UBIQUITIN-PROTEIN LIGASE PRAJA E3 UBIQUITIN-PROTEIN LIGASE RNF115 ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740 negative regulation of response to stimulus#GO:0048585;regulation of epidermal growth factor receptor signaling pathway#GO:0042058;negative regulation of immune system process#GO:0002683;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;macromolecule metabolic process#GO:0043170;regulation of innate immune response#GO:0045088;ubiquitin-dependent protein catabolic process#GO:0006511;regulation of response to stress#GO:0080134;negative regulation of cellular process#GO:0048523;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;regulation of response to stimulus#GO:0048583;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of cell communication#GO:0010646;regulation of response to biotic stimulus#GO:0002831;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;regulation of ERBB signaling pathway#GO:1901184;protein metabolic process#GO:0019538;regulation of defense response#GO:0031347;regulation of immune response#GO:0050776;regulation of response to external stimulus#GO:0032101;proteasomal protein catabolic process#GO:0010498;negative regulation of signal transduction#GO:0009968;cellular process#GO:0009987;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of cell communication#GO:0010648;negative regulation of signaling#GO:0023057;modification-dependent macromolecule catabolic process#GO:0043632;regulation of signaling#GO:0023051;protein catabolic process#GO:0030163 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=10985|UniProtKB=Q9Y619 Q9Y619 SLC25A15 PTHR45624:SF22 MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED MITOCHONDRIAL ORNITHINE TRANSPORTER 1 L-amino acid transmembrane transporter activity#GO:0015179;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;carboxylic acid transmembrane transporter activity#GO:0046943;amino acid transmembrane transporter activity#GO:0015171 L-alpha-amino acid transmembrane transport#GO:1902475;mitochondrial transport#GO:0006839;carboxylic acid transmembrane transport#GO:1905039;mitochondrial transmembrane transport#GO:1990542;localization#GO:0051179;amino acid transmembrane transport#GO:0003333;cellular localization#GO:0051641;transmembrane transport#GO:0055085;L-amino acid transport#GO:0015807;nitrogen compound transport#GO:0071705;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;intracellular transport#GO:0046907;carboxylic acid transport#GO:0046942;organic acid transport#GO:0015849;transport#GO:0006810;amino acid transport#GO:0006865;establishment of localization#GO:0051234 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 transporter#PC00227 HUMAN|HGNC=26960|UniProtKB=Q96KV7 Q96KV7 WDR90 PTHR13720:SF24 WD-40 REPEAT PROTEIN WD REPEAT-CONTAINING PROTEIN 90 microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;microtubule cytoskeleton#GO:0015630;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;centriole#GO:0005814 microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=3334|UniProtKB=P54851 P54851 EMP2 PTHR10671:SF32 EPITHELIAL MEMBRANE PROTEIN-RELATED EPITHELIAL MEMBRANE PROTEIN 2 regulation of response to stimulus#GO:0048583;bleb assembly#GO:0032060;plasma membrane bounded cell projection assembly#GO:0120031;intracellular protein localization#GO:0008104;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cell projection assembly#GO:0030031;cellular component biogenesis#GO:0044085;macromolecule localization#GO:0033036;plasma membrane bounded cell projection organization#GO:0120036;regulation of signal transduction#GO:0009966;regulation of cell-substrate adhesion#GO:0010810;biological regulation#GO:0065007;regulation of cell adhesion#GO:0030155;positive regulation of response to stimulus#GO:0048584;cellular component assembly#GO:0022607;regulation of signaling#GO:0023051;cell adhesion#GO:0007155;positive regulation of signaling#GO:0023056;regulation of cell-matrix adhesion#GO:0001952;localization#GO:0051179;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;cell projection organization#GO:0030030 membrane-bounded organelle#GO:0043227;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;plasma membrane#GO:0005886;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cell periphery#GO:0071944;membrane#GO:0016020 cytoskeletal protein#PC00085 HUMAN|HGNC=6452|UniProtKB=O76011 O76011 KRT34 PTHR23239:SF165 INTERMEDIATE FILAMENT IF ROD DOMAIN-CONTAINING PROTEIN-RELATED structural molecule activity#GO:0005198 intermediate filament cytoskeleton organization#GO:0045104;cell differentiation#GO:0030154;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;supramolecular fiber organization#GO:0097435;anatomical structure development#GO:0048856;tissue morphogenesis#GO:0048729;intermediate filament organization#GO:0045109;animal gross anatomical part developmental process#GO:0160108;intermediate filament-based process#GO:0045103;cytoskeleton organization#GO:0007010;epithelial cell differentiation#GO:0030855;tissue development#GO:0009888;epithelium development#GO:0060429;cellular process#GO:0009987;organelle organization#GO:0006996;morphogenesis of an epithelium#GO:0002009;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;developmental process#GO:0032502 intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;organelle#GO:0043226;supramolecular complex#GO:0099080;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;intermediate filament#GO:0005882;supramolecular fiber#GO:0099512;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228 intermediate filament#PC00129 HUMAN|HGNC=14359|UniProtKB=Q9BZI1 Q9BZI1 IRX2 PTHR11211:SF15 IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX-2 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 neuron differentiation#GO:0030182;developmental process#GO:0032502;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;nervous system development#GO:0007399;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;cell development#GO:0048468 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=12618|UniProtKB=O75604 O75604 USP2 PTHR21646:SF17 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 2 deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;cysteine-type deubiquitinase activity#GO:0004843;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity, acting on a protein#GO:0140096 negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of biological quality#GO:0065008;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of protein stability#GO:0031647;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 cysteine protease#PC00081 HUMAN|HGNC=33230|UniProtKB=Q8N4W9 Q8N4W9 ZNF808 PTHR24376:SF85 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 600-RELATED regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=37155|UniProtKB=P0CJ68 P0CJ68 MTRNR2L1 PTHR33895:SF18 HUMANIN-LIKE 4 HUMANIN-LIKE 1-RELATED signaling receptor regulator activity#GO:0030545;molecular function inhibitor activity#GO:0140678;molecular function regulator activity#GO:0098772;signaling receptor inhibitor activity#GO:0030547 regulation of apoptotic process#GO:0042981;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;negative regulation of apoptotic process#GO:0043066;regulation of cellular process#GO:0050794;negative regulation of programmed cell death#GO:0043069;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067 HUMAN|HGNC=43619|UniProtKB=A6NG13 A6NG13 MGAT4D PTHR12062:SF10 N-ACETYLGLUCOSAMINYLTRANSFERASE VI ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 4-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE-LIKE PROTEIN MGAT4D hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740;acetylglucosaminyltransferase activity#GO:0008375;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757 biosynthetic process#GO:0009058;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;Golgi apparatus subcompartment#GO:0098791;Golgi stack#GO:0005795;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 transferase#PC00220 HUMAN|HGNC=31822|UniProtKB=Q63HM9 Q63HM9 PLCXD3 PTHR13593:SF33 FAMILY NOT NAMED PI-PLC X DOMAIN-CONTAINING PROTEIN 3 phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;phosphoric diester hydrolase activity#GO:0008081;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell junction#GO:0030054 HUMAN|HGNC=615|UniProtKB=Q13790 Q13790 APOF PTHR15011:SF3 APOLIPOPROTEIN F APOLIPOPROTEIN F secondary alcohol metabolic process#GO:1902652;steroid metabolic process#GO:0008202;small molecule metabolic process#GO:0044281;cellular process#GO:0009987;primary metabolic process#GO:0044238;sterol metabolic process#GO:0016125;lipid metabolic process#GO:0006629;cholesterol metabolic process#GO:0008203;metabolic process#GO:0008152;alcohol metabolic process#GO:0006066 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 transfer/carrier protein#PC00219;apolipoprotein#PC00052 HUMAN|HGNC=7712|UniProtKB=O43920 O43920 NDUFS5 PTHR15224:SF1 NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5 NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5 NADH dehydrogenase complex assembly#GO:0010257;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;mitochondrial respiratory chain complex assembly#GO:0033108;mitochondrion organization#GO:0007005;cellular component assembly#GO:0022607;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;mitochondrial respiratory chain complex I assembly#GO:0032981;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085 mitochondrion#GO:0005739;membrane protein complex#GO:0098796;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;transmembrane transporter complex#GO:1902495;mitochondrial membrane#GO:0031966;respiratory chain complex#GO:0098803;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;oxidoreductase complex#GO:1990204;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;respiratory chain complex I#GO:0045271;organelle membrane#GO:0031090;transporter complex#GO:1990351 metabolite interconversion enzyme#PC00262;dehydrogenase#PC00092 HUMAN|HGNC=7838|UniProtKB=Q99801 Q99801 NKX3-1 PTHR24340:SF38 HOMEOBOX PROTEIN NKX HOMEOBOX PROTEIN NKX-3.1 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=17679|UniProtKB=Q9HD47 Q9HD47 RANGRF PTHR15837:SF6 RAN GUANINE NUCLEOTIDE RELEASE FACTOR RAN GUANINE NUCLEOTIDE RELEASE FACTOR ion channel regulator activity#GO:0099106;molecular function regulator activity#GO:0098772;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;transporter regulator activity#GO:0141108;enzyme binding#GO:0019899;transmembrane transporter binding#GO:0044325;binding#GO:0005488;guanyl-nucleotide exchange factor activity#GO:0005085;channel regulator activity#GO:0016247;small GTPase binding#GO:0031267;enzyme regulator activity#GO:0030234;protein binding#GO:0005515 heart process#GO:0003015;regulation of biological process#GO:0050789;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regulation of cellular process#GO:0050794;blood circulation#GO:0008015;circulatory system process#GO:0003013;regulation of biological quality#GO:0065008;heart contraction#GO:0060047;system process#GO:0003008;regulation of membrane potential#GO:0042391 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=20771|UniProtKB=P68371 P68371 TUBB4B PTHR11588:SF247 TUBULIN TUBULIN BETA-4B CHAIN ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;structural molecule activity#GO:0005198;nucleotide binding#GO:0000166;nucleoside phosphate binding#GO:1901265;structural constituent of cytoskeleton#GO:0005200;binding#GO:0005488;guanyl nucleotide binding#GO:0019001;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;ribonucleotide binding#GO:0032553;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363 microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;mitotic cell cycle#GO:0000278;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;cell cycle#GO:0007049;organelle organization#GO:0006996;cellular process#GO:0009987 microtubule cytoskeleton#GO:0015630;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;organelle#GO:0043226;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512 tubulin#PC00228;cytoskeletal protein#PC00085 Huntington disease#P00029>Microtubule#P00780;Cytoskeletal regulation by Rho GTPase#P00016>tubulin#P00526;Huntington disease#P00029>beta-Tubulin#P00790 HUMAN|HGNC=21052|UniProtKB=Q7Z5Y7 Q7Z5Y7 KCTD20 PTHR21637:SF1 BTB/POZ DOMAIN-CONTAINING PROTEIN 10-RELATED BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD20 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=23109|UniProtKB=Q6V0I7 Q6V0I7 FAT4 PTHR24026:SF140 FAT ATYPICAL CADHERIN-RELATED PROTOCADHERIN FAT 4 cellular process#GO:0009987;cell adhesion#GO:0007155;cell-cell adhesion#GO:0098609 cell-cell junction#GO:0005911;cell junction#GO:0030054;cellular anatomical structure#GO:0110165;adherens junction#GO:0005912;anchoring junction#GO:0070161 cadherin#PC00057 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HUMAN|HGNC=10666|UniProtKB=Q9Y365 Q9Y365 STARD10 PTHR19308:SF7 PHOSPHATIDYLCHOLINE TRANSFER PROTEIN START DOMAIN-CONTAINING PROTEIN 10 cytoskeleton#GO:0005856;cell junction#GO:0030054;membraneless organelle#GO:0043228;cytosol#GO:0005829;membrane#GO:0016020;cell-cell junction#GO:0005911;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;microvillus#GO:0005902;actin-based cell projection#GO:0098858;actin cytoskeleton#GO:0015629;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=11220|UniProtKB=Q14515 Q14515 SPARCL1 PTHR13866:SF16 SPARC OSTEONECTIN SPARC-LIKE PROTEIN 1 calcium ion binding#GO:0005509;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;cation binding#GO:0043169;metal ion binding#GO:0046872 developmental process#GO:0032502;sensory organ development#GO:0007423;animal organ development#GO:0048513;multicellular organism development#GO:0007275;embryonic morphogenesis#GO:0048598;inner ear development#GO:0048839;inner ear morphogenesis#GO:0042472;embryo development#GO:0009790;tube development#GO:0035295;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;embryonic organ development#GO:0048568;regulation of synapse organization#GO:0050807;animal gross anatomical part developmental process#GO:0160108;regulation of biological quality#GO:0065008;ear development#GO:0043583;regulation of synapse structure or activity#GO:0050803;anatomical structure development#GO:0048856;tube morphogenesis#GO:0035239;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;sensory organ morphogenesis#GO:0090596;animal organ morphogenesis#GO:0009887;regulation of cellular component organization#GO:0051128 external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 extracellular matrix protein#PC00102;extracellular matrix glycoprotein#PC00100 HUMAN|HGNC=3006|UniProtKB=O94777 O94777 DPM2 PTHR15039:SF11 DOLICHOL PHOSPHATE-MANNOSE BIOSYNTHESIS REGULATORY PROTEIN DOLICHOL PHOSPHATE-MANNOSE BIOSYNTHESIS REGULATORY PROTEIN molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;biosynthetic process#GO:0009058;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex#GO:1990234;endoplasmic reticulum#GO:0005783;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;mannosyltransferase complex#GO:0031501 HUMAN|HGNC=37206|UniProtKB=A6NDZ8 A6NDZ8 MBD3L4 PTHR12396:SF6 METHYL-CPG BINDING PROTEIN, MBD METHYL-CPG-BINDING DOMAIN PROTEIN 3-LIKE 2-RELATED heterochromatin formation#GO:0031507;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of DNA-templated transcription#GO:0006355;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;epigenetic regulation of gene expression#GO:0040029;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;chromatin organization#GO:0006325;negative regulation of cellular process#GO:0048523;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;cellular component assembly#GO:0022607;heterochromatin organization#GO:0070828;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;cellular component organization or biogenesis#GO:0071840;DNA methylation-dependent constitutive heterochromatin formation#GO:0006346;negative regulation of gene expression, epigenetic#GO:0045814;constitutive heterochromatin formation#GO:0140719 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=20420|UniProtKB=Q9H714 Q9H714 RUBCNL PTHR45971:SF2 PHOX (PX) DOMAIN-CONTAINING PROTEIN PROTEIN ASSOCIATED WITH UVRAG AS AUTOPHAGY ENHANCER phosphatidylinositol phosphate binding#GO:1901981;lipid binding#GO:0008289;binding#GO:0005488;phospholipid binding#GO:0005543 establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;vesicle organization#GO:0016050;autophagosome maturation#GO:0097352;metabolic process#GO:0008152;transport#GO:0006810;vesicle-mediated transport#GO:0016192;organelle fusion#GO:0048284;organelle membrane fusion#GO:0090174;macroautophagy#GO:0016236;membrane organization#GO:0061024;membrane fusion#GO:0061025;organelle organization#GO:0006996;cellular process#GO:0009987;autophagy#GO:0006914;cellular component disassembly#GO:0022411;localization#GO:0051179;process utilizing autophagic mechanism#GO:0061919;catabolic process#GO:0009056;protein-containing complex disassembly#GO:0032984;vesicle fusion#GO:0006906;cellular component organization#GO:0016043 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;vacuole#GO:0005773;membrane#GO:0016020;vacuolar membrane#GO:0005774;intracellular anatomical structure#GO:0005622;autophagosome membrane#GO:0000421;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane-bounded organelle#GO:0043227;autophagosome#GO:0005776;intracellular organelle#GO:0043229 HUMAN|HGNC=17353|UniProtKB=Q9NRW3 Q9NRW3 APOBEC3C PTHR13857:SF46 MRNA EDITING ENZYME DNA DC-DU-EDITING ENZYME APOBEC-3C hydrolase activity#GO:0016787;RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;deaminase activity#GO:0019239;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;catalytic activity#GO:0003824 negative regulation of cellular process#GO:0048523;defense response#GO:0006952;response to external stimulus#GO:0009605;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;response to other organism#GO:0051707;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;macromolecule modification#GO:0043412;response to virus#GO:0009615;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cytidine to uridine editing#GO:0016554;response to external biotic stimulus#GO:0043207;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;cellular process#GO:0009987;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;negative regulation of macromolecule biosynthetic process#GO:0010558;RNA modification#GO:0009451;base conversion or substitution editing#GO:0016553;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;RNA metabolic process#GO:0016070;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;defense response to virus#GO:0051607;negative regulation of metabolic process#GO:0009892;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896 intracellular organelle#GO:0043229;P-body#GO:0000932;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;nucleus#GO:0005634;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;organelle#GO:0043226;ribonucleoprotein granule#GO:0035770;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165 RNA processing factor#PC00147 HUMAN|HGNC=12523|UniProtKB=P11684 P11684 SCGB1A1 PTHR10136:SF6 SECRETOGLOBIN FAMILY 1 MEMBER UTEROGLOBIN extracellular region#GO:0005576;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 cytokine#PC00083 HUMAN|HGNC=20846|UniProtKB=Q86YZ3 Q86YZ3 HRNR PTHR22571:SF25 FILAGGRIN-RELATED HORNERIN epithelium development#GO:0060429;tissue development#GO:0009888;skin development#GO:0043588;animal organ development#GO:0048513;anatomical structure development#GO:0048856;animal gross anatomical part developmental process#GO:0160108;epidermis development#GO:0008544;developmental process#GO:0032502 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;plasma membrane#GO:0005886 cytoskeletal protein#PC00085 HUMAN|HGNC=30081|UniProtKB=O95707 O95707 POP4 PTHR13348:SF0 RIBONUCLEASE P SUBUNIT P29 RIBONUCLEASE P PROTEIN SUBUNIT P29 binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774 protein-containing complex#GO:0032991;ribonuclease MRP complex#GO:0000172;intracellular protein-containing complex#GO:0140535;sno(s)RNA-containing ribonucleoprotein complex#GO:0005732;catalytic complex#GO:1902494;endoribonuclease complex#GO:1902555;endonuclease complex#GO:1905348;ribonuclease P complex#GO:0030677;ribonucleoprotein complex#GO:1990904 endoribonuclease#PC00094 HUMAN|HGNC=1935|UniProtKB=Q9UKJ5 Q9UKJ5 CHIC2 PTHR13005:SF3 CYSTEINE-RICH HYDROPHOBIC DOMAIN PROTEIN BRAIN X-LINKED PROTEIN CYSTEINE-RICH HYDROPHOBIC DOMAIN-CONTAINING PROTEIN 2 intracellular organelle#GO:0043229;Golgi-associated vesicle#GO:0005798;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;vesicle#GO:0031982;cell periphery#GO:0071944;intracellular vesicle#GO:0097708;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=4847|UniProtKB=O43612 O43612 HCRT PTHR15173:SF2 OREXIN HYPOCRETIN NEUROPEPTIDE PRECURSOR HUMAN|HGNC=11612|UniProtKB=P23193 P23193 TCEA1 PTHR11477:SF1 TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN TRANSCRIPTION ELONGATION FACTOR A PROTEIN 1 transcription regulator activity#GO:0140110;transcription elongation factor activity#GO:0003711 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;DNA-templated transcription elongation#GO:0006354;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;transcription elongation by RNA polymerase II#GO:0006368;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;transcription by RNA polymerase II#GO:0006366;macromolecule metabolic process#GO:0043170 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031;general transcription factor#PC00259 HUMAN|HGNC=10295|UniProtKB=Q92834 Q92834 RPGR PTHR45622:SF75 UBIQUITIN-PROTEIN LIGASE E3A-RELATED X-LINKED RETINITIS PIGMENTOSA GTPASE REGULATOR ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740 protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;localization#GO:0051179;sensory perception#GO:0007600;intraciliary transport#GO:0042073;microtubule-based movement#GO:0007018;visual perception#GO:0007601;catabolic process#GO:0009056;modification-dependent protein catabolic process#GO:0019941;protein modification process#GO:0036211;sensory perception of light stimulus#GO:0050953;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;system process#GO:0003008;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;macromolecule metabolic process#GO:0043170;transport#GO:0006810;intracellular transport#GO:0046907;post-translational protein modification#GO:0043687;plasma membrane bounded cell projection organization#GO:0120036;multicellular organismal process#GO:0032501;cytoskeleton-dependent intracellular transport#GO:0030705;cilium organization#GO:0044782;cellular localization#GO:0051641;nervous system process#GO:0050877;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;microtubule-based transport#GO:0099111;protein modification by small protein conjugation or removal#GO:0070647;cell projection organization#GO:0030030;protein modification by small protein conjugation#GO:0032446;cellular component organization#GO:0016043;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;protein ubiquitination#GO:0016567;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;organelle organization#GO:0006996 Golgi apparatus#GO:0005794;cytoplasm#GO:0005737;endomembrane system#GO:0012505;photoreceptor cell cilium#GO:0097733;neuron projection#GO:0043005;9+0 non-motile cilium#GO:0097731;non-motile cilium#GO:0097730;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cilium#GO:0005929;intracellular organelle#GO:0043229;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;photoreceptor outer segment#GO:0001750;organelle#GO:0043226 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=160|UniProtKB=O94805 O94805 ACTL6B PTHR11937:SF196 ACTIN ACTIN-LIKE PROTEIN 6B binding#GO:0005488;structural constituent of cytoskeleton#GO:0005200;chromatin binding#GO:0003682;structural molecule activity#GO:0005198 developmental process#GO:0032502;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;regulation of RNA biosynthetic process#GO:2001141;chromatin organization#GO:0006325;biological regulation#GO:0065007;nervous system development#GO:0007399;animal gross anatomical part developmental process#GO:0160108;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;chromatin remodeling#GO:0006338 membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;histone acetyltransferase complex#GO:0000123;transferase complex#GO:1990234;protein-containing complex#GO:0032991;H4 histone acetyltransferase complex#GO:1902562;NuA4 histone acetyltransferase complex#GO:0035267;intracellular membraneless organelle#GO:0043232;nucleus#GO:0005634;chromatin#GO:0000785;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;acetyltransferase complex#GO:1902493;ATPase complex#GO:1904949;protein acetyltransferase complex#GO:0031248;SWI/SNF complex#GO:0016514;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;SWI/SNF superfamily-type complex#GO:0070603 actin and actin related protein#PC00039 HUMAN|HGNC=12422|UniProtKB=Q9NNX1 Q9NNX1 TUFT1 PTHR23171:SF4 GDOWN1 TUFTELIN membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;membraneless organelle#GO:0043228;intracellular protein-containing complex#GO:0140535;I band#GO:0031674;transferase complex#GO:1990234;RNA polymerase II, core complex#GO:0005665;intracellular membrane-bounded organelle#GO:0043231;nuclear DNA-directed RNA polymerase complex#GO:0055029;RNA polymerase II, holoenzyme#GO:0016591;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;membrane-bounded organelle#GO:0043227;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;contractile muscle fiber#GO:0043292;sarcomere#GO:0030017;nuclear protein-containing complex#GO:0140513;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;organelle lumen#GO:0043233;myofibril#GO:0030016;supramolecular fiber#GO:0099512;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 HUMAN|HGNC=7774|UniProtKB=O94916 O94916 NFAT5 PTHR12533:SF10 NFAT NUCLEAR FACTOR OF ACTIVATED T-CELLS 5 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;intracellular signaling cassette#GO:0141124;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of biological process#GO:0050789;signaling#GO:0023052;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;calcium-mediated signaling#GO:0019722;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;intracellular signal transduction#GO:0035556;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;cell communication#GO:0007154;regulation of DNA-templated transcription#GO:0006355;cellular response to stimulus#GO:0051716;calcineurin-NFAT signaling cascade#GO:0033173;calcineurin-mediated signaling#GO:0097720;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 Rel homology transcription factor#PC00252;gene-specific transcriptional regulator#PC00264;immunoglobulin fold transcription factor#PC00251 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>NFAT#P00851 HUMAN|HGNC=20998|UniProtKB=Q9GZU0 Q9GZU0 C6orf62 PTHR28336:SF1 BA1-643 SIMILAR TO CDNA SEQUENCE BC005537 HUMAN|HGNC=19594|UniProtKB=Q8NG81 Q8NG81 OR2M7 PTHR26453:SF314 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2M7 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 detection of chemical stimulus#GO:0009593;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;response to stimulus#GO:0050896;response to chemical#GO:0042221;nervous system process#GO:0050877;sensory perception#GO:0007600;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=13961|UniProtKB=P35410 P35410 MAS1L PTHR11334:SF22 MAS-RELATED G-PROTEIN COUPLED RECEPTOR MAS-RELATED G PROTEIN-COUPLED RECEPTOR MRG-RELATED molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=8906|UniProtKB=Q96G03 Q96G03 PGM2 PTHR45745:SF3 PHOSPHOMANNOMUTASE 45A PHOSPHOPENTOMUTASE isomerase activity#GO:0016853;intramolecular phosphotransferase activity#GO:0016868;intramolecular transferase activity#GO:0016866;catalytic activity#GO:0003824 small molecule metabolic process#GO:0044281;nucleoside metabolic process#GO:0009116;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;purine-containing compound metabolic process#GO:0072521;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;purine-containing compound biosynthetic process#GO:0072522;nucleobase-containing compound biosynthetic process#GO:0034654;small molecule biosynthetic process#GO:0044283;purine nucleoside metabolic process#GO:0042278 isomerase#PC00135;metabolite interconversion enzyme#PC00262;mutase#PC00160 HUMAN|HGNC=33238|UniProtKB=Q6YP21 Q6YP21 KYAT3 PTHR43807:SF6 FI04487P KYNURENINE--OXOGLUTARATE TRANSAMINASE 3 transferase activity#GO:0016740;catalytic activity#GO:0003824;transaminase activity#GO:0008483 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739 metabolite interconversion enzyme#PC00262;transaminase#PC00216;transferase#PC00220 HUMAN|HGNC=2370|UniProtKB=O60244 O60244 MED14 PTHR12809:SF2 MEDIATOR COMPLEX SUBUNIT MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 14 transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 core mediator complex#GO:0070847;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;mediator complex#GO:0016592;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667 RNA metabolism protein#PC00031;general transcription factor#PC00259 HUMAN|HGNC=1105|UniProtKB=Q58F21 Q58F21 BRDT PTHR22880:SF175 FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS BROMODOMAIN TESTIS-SPECIFIC PROTEIN chromatin-protein adaptor activity#GO:0140463;histone reader activity#GO:0140566;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;chromatin remodeling#GO:0006338;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;chromatin organization#GO:0006325 membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;chromatin#GO:0000785;nucleus#GO:0005634 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=24838|UniProtKB=Q6UWT2 Q6UWT2 ENHO PTHR38492:SF1 ADROPIN ADROPIN positive regulation of signaling#GO:0023056;regulation of Notch signaling pathway#GO:0008593;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;positive regulation of Notch signaling pathway#GO:0045747;positive regulation of response to stimulus#GO:0048584;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789;positive regulation of cellular process#GO:0048522;positive regulation of signal transduction#GO:0009967 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=25181|UniProtKB=Q96CE8 Q96CE8 TM4SF18 PTHR14198:SF14 TRANSMEMBRANE 4 L6 FAMILY MEMBER 1-RELATED TRANSMEMBRANE 4 L6 FAMILY MEMBER 18 cellular anatomical structure#GO:0110165;membrane#GO:0016020 HUMAN|HGNC=2547|UniProtKB=Q9UBR2 Q9UBR2 CTSZ PTHR12411:SF929 CYSTEINE PROTEASE FAMILY C1-RELATED CATHEPSIN Z catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;cysteine-type endopeptidase activity#GO:0004197;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175 protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;primary metabolic process#GO:0044238;catabolic process#GO:0009056 vacuole#GO:0005773;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;extracellular region#GO:0005576 cysteine protease#PC00081;protein modifying enzyme#PC00260;protease#PC00190 HUMAN|Ensembl=ENSG00000300510.1|UniProtKB=C9JQL5 C9JQL5 PTHR13999:SF23 INTERFERON INDUCIBLE TRANSMEMBRANE PROTEIN DISPANIN SUBFAMILY A MEMBER 2D-RELATED response to peptide#GO:1901652;type I interferon-mediated signaling pathway#GO:0060337;immune system process#GO:0002376;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052;negative regulation of biological process#GO:0048519;defense response to virus#GO:0051607;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;cell surface receptor signaling pathway#GO:0007166;defense response to other organism#GO:0098542;response to cytokine#GO:0034097;response to chemical#GO:0042221;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;response to type II interferon#GO:0034341;cellular process#GO:0009987;defense response to symbiont#GO:0140546;signal transduction#GO:0007165;response to virus#GO:0009615;cell communication#GO:0007154;cytokine-mediated signaling pathway#GO:0019221;regulation of cellular process#GO:0050794;response to external biotic stimulus#GO:0043207;cellular response to stimulus#GO:0051716;innate immune response#GO:0045087;defense response#GO:0006952;response to external stimulus#GO:0009605;response to other organism#GO:0051707;biological regulation#GO:0065007;immune response#GO:0006955 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 defense/immunity protein#PC00090 HUMAN|HGNC=19165|UniProtKB=O60343 O60343 TBC1D4 PTHR22957:SF195 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN TBC1 DOMAIN FAMILY MEMBER 4 enzyme activator activity#GO:0008047;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 localization#GO:0051179;establishment of localization#GO:0051234;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;transport#GO:0006810 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cytosol#GO:0005829;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 protein-binding activity modulator#PC00095;G-protein modulator#PC00022;GTPase-activating protein#PC00257 HUMAN|HGNC=25419|UniProtKB=Q3SXY8 Q3SXY8 ARL13B PTHR46090:SF3 ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 13B ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 13B plasma membrane bounded cell projection assembly#GO:0120031;protein localization to cell periphery#GO:1990778;cellular component organization or biogenesis#GO:0071840;intracellular protein localization#GO:0008104;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;macromolecule localization#GO:0033036;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;organelle assembly#GO:0070925;localization within membrane#GO:0051668;cellular localization#GO:0051641;non-motile cilium assembly#GO:1905515;localization#GO:0051179;cilium organization#GO:0044782;cilium assembly#GO:0060271;cellular component organization#GO:0016043;protein localization to membrane#GO:0072657;protein localization to organelle#GO:0033365;cell projection organization#GO:0030030;protein localization to cilium#GO:0061512 bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;plasma membrane region#GO:0098590;ciliary membrane#GO:0060170;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;cell projection membrane#GO:0031253;non-motile cilium#GO:0097730;membrane-bounded organelle#GO:0043227;cilium#GO:0005929;cellular anatomical structure#GO:0110165;organelle#GO:0043226;motile cilium#GO:0031514;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995 HUMAN|HGNC=17369|UniProtKB=Q9ULW3 Q9ULW3 ABT1 PTHR12311:SF7 ACTIVATOR OF BASAL TRANSCRIPTION 1 ACTIVATOR OF BASAL TRANSCRIPTION 1 binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;macromolecule biosynthetic process#GO:0009059;ribosomal small subunit assembly#GO:0000028;macromolecule metabolic process#GO:0043170;rRNA metabolic process#GO:0016072;endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000447;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;protein-RNA complex assembly#GO:0022618;rRNA processing#GO:0006364;organelle assembly#GO:0070925;gene expression#GO:0010467;cellular component assembly#GO:0022607;maturation of SSU-rRNA#GO:0030490;RNA processing#GO:0006396;endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000479;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000480;cellular process#GO:0009987;protein-RNA complex organization#GO:0071826;endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000472;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;ribosomal small subunit biogenesis#GO:0042274;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;ribonucleoprotein complex biogenesis#GO:0022613;maturation of 5.8S rRNA#GO:0000460;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;protein-containing complex assembly#GO:0065003;RNA metabolic process#GO:0016070;ribosome biogenesis#GO:0042254;ribosome assembly#GO:0042255;nucleic acid biosynthetic process#GO:0141187 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634 HUMAN|HGNC=5248|UniProtKB=Q12988 Q12988 HSPB3 PTHR47097:SF1 HEAT SHOCK PROTEIN BETA-3 HEAT SHOCK PROTEIN BETA-3 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nuclear speck#GO:0016607;organelle lumen#GO:0043233;membraneless organelle#GO:0043228;intracellular membraneless organelle#GO:0043232;nuclear body#GO:0016604;cytoplasm#GO:0005737;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974 HUMAN|HGNC=30275|UniProtKB=Q86VW2 Q86VW2 ARHGEF25 PTHR22826:SF117 RHO GUANINE EXCHANGE FACTOR-RELATED RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 25 enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell morphogenesis#GO:0000902;cell development#GO:0048468;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;anatomical structure development#GO:0048856;system development#GO:0048731;axonogenesis#GO:0007409;neuron development#GO:0048666;neuron projection development#GO:0031175;axon guidance#GO:0007411;axon development#GO:0061564;cellular process#GO:0009987;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cell morphogenesis involved in neuron differentiation#GO:0048667;developmental process#GO:0032502;neuron differentiation#GO:0030182;neuron projection morphogenesis#GO:0048812;plasma membrane bounded cell projection morphogenesis#GO:0120039;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;cell projection morphogenesis#GO:0048858;neuron projection guidance#GO:0097485;neurogenesis#GO:0022008 cellular anatomical structure#GO:0110165;extrinsic component of membrane#GO:0019898;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 protein-binding activity modulator#PC00095;guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=32308|UniProtKB=Q5T7M4 Q5T7M4 C1QTNF12 PTHR24019:SF12 ADIPOLIN ADIPOLIN receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677;hormone activity#GO:0005179 regulation of response to stimulus#GO:0048583;regulation of carbohydrate metabolic process#GO:0006109;negative regulation of cellular process#GO:0048523;regulation of transport#GO:0051049;regulation of localization#GO:0032879;regulation of biosynthetic process#GO:0009889;positive regulation of transport#GO:0051050;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of signal transduction#GO:0009966;positive regulation of response to stimulus#GO:0048584;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;regulation of biological process#GO:0050789;regulation of transmembrane transport#GO:0034762;positive regulation of signal transduction#GO:0009967;negative regulation of biological process#GO:0048519;regulation of cell communication#GO:0010646;negative regulation of metabolic process#GO:0009892;regulation of carbohydrate biosynthetic process#GO:0043255;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 peptide hormone#PC00179;intercellular signal molecule#PC00207 HUMAN|HGNC=29905|UniProtKB=O75534 O75534 CSDE1 PTHR12913:SF1 UNR PROTEIN N-RAS UPSTREAM GENE PROTEIN COLD SHOCK DOMAIN-CONTAINING PROTEIN E1 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;protein-RNA adaptor activity#GO:0140517 negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of biological quality#GO:0065008;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;RNA stabilization#GO:0043489;negative regulation of metabolic process#GO:0009892;regulation of mRNA stability#GO:0043488;regulation of biological process#GO:0050789;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;regulation of mRNA metabolic process#GO:1903311;negative regulation of RNA metabolic process#GO:0051253;mRNA stabilization#GO:0048255;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;negative regulation of catabolic process#GO:0009895;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;regulation of RNA stability#GO:0043487;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;regulation of biosynthetic process#GO:0009889;negative regulation of RNA catabolic process#GO:1902369;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular protein-containing complex#GO:0140535;cytosol#GO:0005829 HUMAN|HGNC=14601|UniProtKB=O75521 O75521 ECI2 PTHR43684:SF17 FAMILY NOT NAMED ENOYL-COA DELTA ISOMERASE 2 catalytic activity#GO:0003824;isomerase activity#GO:0016853;intramolecular oxidoreductase activity#GO:0016860 oxoacid metabolic process#GO:0043436;lipid oxidation#GO:0034440;fatty acid catabolic process#GO:0009062;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;small molecule catabolic process#GO:0044282;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;fatty acid oxidation#GO:0019395;fatty acid beta-oxidation#GO:0006635;lipid metabolic process#GO:0006629;lipid modification#GO:0030258;carboxylic acid catabolic process#GO:0046395;lipid catabolic process#GO:0016042;cellular process#GO:0009987;monocarboxylic acid catabolic process#GO:0072329 microbody#GO:0042579;mitochondrion#GO:0005739;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;peroxisome#GO:0005777;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;peroxisomal matrix#GO:0005782;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=1763|UniProtKB=P55283 P55283 CDH4 PTHR24027:SF81 CADHERIN-23 CADHERIN-4 protein binding#GO:0005515;beta-catenin binding#GO:0008013;binding#GO:0005488;cell adhesion molecule binding#GO:0050839 cell-cell adhesion#GO:0098609;cellular process#GO:0009987;cell adhesion#GO:0007155;cell motility#GO:0048870;cell migration#GO:0016477 membrane protein complex#GO:0098796;membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;extrinsic component of membrane#GO:0019898;extrinsic component of plasma membrane#GO:0019897 cadherin#PC00057;cell adhesion molecule#PC00069 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HUMAN|HGNC=15084|UniProtKB=Q96R47 Q96R47 OR2A14 PTHR26453:SF27 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2A14 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 sensory perception#GO:0007600;nervous system process#GO:0050877;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;system process#GO:0003008;detection of chemical stimulus#GO:0009593;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;response to stimulus#GO:0050896;response to chemical#GO:0042221;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=17625|UniProtKB=Q2M3X9 Q2M3X9 ZNF674 PTHR24381:SF125 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 674 transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=20696|UniProtKB=Q9H9T3 Q9H9T3 ELP3 PTHR11135:SF0 HISTONE ACETYLTRANSFERASE-RELATED ELONGATOR COMPLEX PROTEIN 3 tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;RNA biosynthetic process#GO:0032774;tRNA modification#GO:0006400;tRNA wobble base modification#GO:0002097;tRNA wobble uridine modification#GO:0002098;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;elongator holoenzyme complex#GO:0033588;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 histone modifying enzyme#PC00261;chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=17441|UniProtKB=Q9UKL0 Q9UKL0 RCOR1 PTHR16089:SF11 REST COREPRESSOR COREST PROTEIN-RELATED REST COREPRESSOR 1 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714 negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 intracellular organelle lumen#GO:0070013;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nuclear protein-containing complex#GO:0140513;transcription regulator complex#GO:0005667;membrane-enclosed lumen#GO:0031974;histone deacetylase complex#GO:0000118;nucleus#GO:0005634;protein-containing complex#GO:0032991 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=29101|UniProtKB=Q86XL3 Q86XL3 ANKLE2 PTHR12349:SF4 ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2 ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2 binding#GO:0005488;phosphatase binding#GO:0019902;enzyme binding#GO:0019899;protein binding#GO:0005515;protein phosphatase binding#GO:0019903 endomembrane system organization#GO:0010256;membrane organization#GO:0061024;cellular component assembly#GO:0022607;cellular process#GO:0009987;nuclear membrane organization#GO:0071763;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;nuclear envelope organization#GO:0006998;mitotic cell cycle process#GO:1903047;nucleus organization#GO:0006997;cellular component organization or biogenesis#GO:0071840;mitotic cell cycle#GO:0000278;cell cycle process#GO:0022402;mitotic nuclear division#GO:0140014;membrane assembly#GO:0071709;cellular component organization#GO:0016043;cell cycle#GO:0007049;organelle fission#GO:0048285;nuclear division#GO:0000280 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 HUMAN|HGNC=37284|UniProtKB=C9J069 C9J069 AJM1 PTHR21517:SF3 APICAL JUNCTION COMPONENT 1 HOMOLOG APICAL JUNCTION COMPONENT 1 HOMOLOG cell junction organization#GO:0034330;cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;cellular process#GO:0009987;cell-cell junction organization#GO:0045216 anchoring junction#GO:0070161;cell junction#GO:0030054;apical junction complex#GO:0043296;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;cell-cell junction#GO:0005911;membrane#GO:0016020 HUMAN|HGNC=8801|UniProtKB=Q9NRA1 Q9NRA1 PDGFC PTHR11633:SF5 PLATELET-DERIVED GROWTH FACTOR PLATELET-DERIVED GROWTH FACTOR C protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102;growth factor receptor binding#GO:0070851 regulation of cell communication#GO:0010646;positive regulation of ERK1 and ERK2 cascade#GO:0070374;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051896;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;regulation of cell motility#GO:2000145;enzyme-linked receptor protein signaling pathway#GO:0007167;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of locomotion#GO:0040012;positive regulation of response to stimulus#GO:0048584;positive regulation of cellular process#GO:0048522;positive regulation of cell migration#GO:0030335;positive regulation of locomotion#GO:0040017;positive regulation of MAPK cascade#GO:0043410;positive regulation of intracellular signal transduction#GO:1902533;regulation of cell migration#GO:0030334;regulation of response to stimulus#GO:0048583;signaling#GO:0023052;response to stimulus#GO:0050896;positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051897;regulation of biological process#GO:0050789;positive regulation of cell motility#GO:2000147;positive regulation of cell population proliferation#GO:0008284;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;regulation of ERK1 and ERK2 cascade#GO:0070372;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of MAPK cascade#GO:0043408;cell surface receptor signaling pathway#GO:0007166 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 growth factor#PC00112 Angiogenesis#P00005>PDGF#P00224 HUMAN|HGNC=29121|UniProtKB=Q9Y4B5 Q9Y4B5 MTCL1 PTHR15742:SF3 GIRDIN MICROTUBULE CROSS-LINKING FACTOR 1 protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;microtubule binding#GO:0008017;binding#GO:0005488 establishment or maintenance of apical/basal cell polarity#GO:0035088;establishment or maintenance of cell polarity#GO:0007163;establishment or maintenance of bipolar cell polarity#GO:0061245;microtubule bundle formation#GO:0001578;microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;establishment or maintenance of epithelial cell apical/basal polarity#GO:0045197;microtubule-based process#GO:0007017;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;cytoskeleton organization#GO:0007010 organelle#GO:0043226;cellular anatomical structure#GO:0110165;spindle pole#GO:0000922;midbody#GO:0030496;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;intracellular organelle#GO:0043229;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;supramolecular complex#GO:0099080;plasma membrane region#GO:0098590;supramolecular polymer#GO:0099081;cell periphery#GO:0071944;microtubule cytoskeleton#GO:0015630;membrane#GO:0016020;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;spindle#GO:0005819;cytoskeleton#GO:0005856 HUMAN|HGNC=16935|UniProtKB=O95352 O95352 ATG7 PTHR10953:SF3 UBIQUITIN-ACTIVATING ENZYME E1 UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7 catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;ubiquitin-like modifier activating enzyme activity#GO:0008641;transferase activity, transferring phosphorus-containing groups#GO:0016772;ligase activity#GO:0016874;sulfurtransferase activity#GO:0016783;thiosulfate-cyanide sulfurtransferase activity#GO:0004792;transferase activity, transferring sulphur-containing groups#GO:0016782;Atg12 activating enzyme activity#GO:0019778;ligase activity, forming carbon-sulfur bonds#GO:0016877;ATP-dependent activity#GO:0140657 protein modification by small protein conjugation#GO:0032446;cellular component organization#GO:0016043;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;protein modification by small protein conjugation or removal#GO:0070647;process utilizing autophagic mechanism#GO:0061919;autophagy#GO:0006914;cellular process#GO:0009987;autophagosome organization#GO:1905037;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;response to stress#GO:0006950;cellular component assembly#GO:0022607;metabolic process#GO:0008152;autophagosome assembly#GO:0000045;cellular component organization or biogenesis#GO:0071840;cellular response to stimulus#GO:0051716;response to starvation#GO:0042594;protein modification process#GO:0036211;primary metabolic process#GO:0044238;piecemeal microautophagy of the nucleus#GO:0034727;catabolic process#GO:0009056;organelle assembly#GO:0070925;vacuole organization#GO:0007033;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;response to nutrient levels#GO:0031667;macroautophagy#GO:0016236;post-translational protein modification#GO:0043687;cellular response to nutrient levels#GO:0031669;cellular response to starvation#GO:0009267;autophagy of mitochondrion#GO:0000422;macromolecule metabolic process#GO:0043170;mitophagy#GO:0000423 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;phagophore assembly site#GO:0000407 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Ubiquitin proteasome pathway#P00060>E1#P01492 HUMAN|HGNC=19032|UniProtKB=Q9BU76 Q9BU76 MMTAG2 PTHR14580:SF0 MULTIPLE MYELOMA TUMOR-ASSOCIATED PROTEIN 2 FAMILY MEMBER MULTIPLE MYELOMA TUMOR-ASSOCIATED PROTEIN 2 HUMAN|HGNC=23245|UniProtKB=Q6S9Z5 Q6S9Z5 ZNF474 PTHR13555:SF67 C2H2 ZINC FINGER CGI-62-RELATED ZINC FINGER PROTEIN 474 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=17590|UniProtKB=Q9HB07 Q9HB07 MYG1 PTHR11215:SF1 METAL DEPENDENT HYDROLASE - RELATED MYG1 EXONUCLEASE hydrolase#PC00121 HUMAN|HGNC=29181|UniProtKB=Q9BQ70 Q9BQ70 TCF25 PTHR22684:SF0 NULP1-RELATED RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT TCF25 protein-containing complex#GO:0032991 HUMAN|HGNC=18265|UniProtKB=Q96LB4 Q96LB4 ATP6V1G3 PTHR12713:SF5 VACUOLAR ATP SYNTHASE SUBUNIT G V-TYPE PROTON ATPASE SUBUNIT G 3 monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;vesicle-mediated transport#GO:0016192;developmental maturation#GO:0021700;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;organelle organization#GO:0006996;cellular homeostasis#GO:0019725;vesicle organization#GO:0016050;vesicle-mediated transport in synapse#GO:0099003;establishment of localization#GO:0051234;synaptic vesicle maturation#GO:0016188;proton transmembrane transport#GO:1902600;cellular component organization or biogenesis#GO:0071840;transport#GO:0006810;synaptic vesicle cycle#GO:0099504;developmental process#GO:0032502;homeostatic process#GO:0042592;cellular component organization#GO:0016043;monoatomic ion transport#GO:0006811;cellular localization#GO:0051641;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179 proton-transporting two-sector ATPase complex#GO:0016469;cell junction#GO:0030054;transporter complex#GO:1990351;bounding membrane of organelle#GO:0098588;secretory vesicle#GO:0099503;presynapse#GO:0098793;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;vacuole#GO:0005773;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;ATPase complex#GO:1904949;ATPase dependent transmembrane transport complex#GO:0098533;intracellular vesicle#GO:0097708;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;vacuolar membrane#GO:0005774;proton-transporting V-type ATPase complex#GO:0033176;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;membrane#GO:0016020;transport vesicle#GO:0030133;endomembrane system#GO:0012505;transport vesicle membrane#GO:0030658;vacuolar proton-transporting V-type ATPase complex#GO:0016471;catalytic complex#GO:1902494;transmembrane transporter complex#GO:1902495;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane protein complex#GO:0098796;vesicle#GO:0031982;synaptic vesicle membrane#GO:0030672;synaptic vesicle#GO:0008021;cation-transporting ATPase complex#GO:0090533;vacuolar proton-transporting V-type ATPase, V1 domain#GO:0000221;intracellular membrane-bounded organelle#GO:0043231 ATP synthase#PC00002 HUMAN|HGNC=20370|UniProtKB=Q8N6K0 Q8N6K0 TEX29 PTHR37339:SF1 TESTIS-EXPRESSED PROTEIN 29 TESTIS-EXPRESSED PROTEIN 29 HUMAN|HGNC=6860|UniProtKB=P41279 P41279 MAP3K8 PTHR48016:SF31 MAP KINASE KINASE KINASE SSK2-RELATED-RELATED MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 8 intracellular signal transduction#GO:0035556;MAPK cascade#GO:0000165;cell communication#GO:0007154;signaling#GO:0023052;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 non-receptor serine/threonine protein kinase#PC00167 Gonadotropin-releasing hormone receptor pathway#P06664>MAP3Ks#P06834;Toll receptor signaling pathway#P00054>TPL2#P01364 HUMAN|HGNC=13787|UniProtKB=Q9HB09 Q9HB09 BCL2L12 PTHR14965:SF2 SI:CH73-248E21.1 BCL-2-LIKE PROTEIN 12 negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;regulation of cellular response to stress#GO:0080135;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;regulation of apoptotic signaling pathway#GO:2001233;negative regulation of apoptotic signaling pathway#GO:2001234;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;regulation of intrinsic apoptotic signaling pathway#GO:2001242;regulation of biological process#GO:0050789;regulation of response to stress#GO:0080134;negative regulation of cellular process#GO:0048523;regulation of apoptotic process#GO:0042981;regulation of response to stimulus#GO:0048583;negative regulation of intrinsic apoptotic signaling pathway#GO:2001243;negative regulation of response to stimulus#GO:0048585;negative regulation of apoptotic process#GO:0043066;negative regulation of signal transduction#GO:0009968;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of programmed cell death#GO:0043069 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=18554|UniProtKB=Q9BZM1 Q9BZM1 PLA2G12A PTHR12824:SF7 GROUP XII SECRETORY PHOSPHOLIPASE A2 FAMILY MEMBER GROUP XIIA SECRETORY PHOSPHOLIPASE A2 A2-type glycerophospholipase activity#GO:0004623;hydrolase activity, acting on ester bonds#GO:0016788;phospholipase activity#GO:0120569;catalytic activity#GO:0003824;glycerophospholipase activity#GO:0004620;hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689;lipase activity#GO:0016298 hydrolase#PC00121;lipase#PC00143;phospholipase#PC00186 HUMAN|HGNC=27962|UniProtKB=Q86WV6 Q86WV6 STING1 PTHR34339:SF1 STIMULATOR OF INTERFERON GENES PROTEIN STIMULATOR OF INTERFERON GENES PROTEIN small molecule binding#GO:0036094;binding#GO:0005488;anion binding#GO:0043168;ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265;guanyl nucleotide binding#GO:0019001;guanyl ribonucleotide binding#GO:0032561;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;nucleotide binding#GO:0000166 cellular component organization or biogenesis#GO:0071840;autophagosome assembly#GO:0000045;positive regulation of immune system process#GO:0002684;organelle organization#GO:0006996;response to biotic stimulus#GO:0009607;cellular component biogenesis#GO:0044085;autophagosome organization#GO:1905037;cellular process#GO:0009987;defense response to symbiont#GO:0140546;activation of immune response#GO:0002253;positive regulation of biological process#GO:0048518;defense response to other organism#GO:0098542;regulation of response to external stimulus#GO:0032101;positive regulation of macromolecule metabolic process#GO:0010604;immune system process#GO:0002376;positive regulation of macromolecule biosynthetic process#GO:0010557;process utilizing autophagic mechanism#GO:0061919;regulation of autophagy#GO:0010506;positive regulation of multicellular organismal process#GO:0051240;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of response to stimulus#GO:0048583;positive regulation of defense response#GO:0031349;positive regulation of immune response#GO:0050778;regulation of biosynthetic process#GO:0009889;innate immune response#GO:0045087;positive regulation of catabolic process#GO:0009896;regulation of innate immune response#GO:0045088;regulation of catabolic process#GO:0009894;defense response#GO:0006952;positive regulation of response to biotic stimulus#GO:0002833;regulation of metabolic process#GO:0019222;regulation of cytokine production#GO:0001817;immune response#GO:0006955;positive regulation of cellular process#GO:0048522;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of defense response#GO:0031347;regulation of immune response#GO:0050776;response to virus#GO:0009615;positive regulation of type I interferon production#GO:0032481;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;metabolic process#GO:0008152;positive regulation of response to external stimulus#GO:0032103;regulation of macroautophagy#GO:0016241;response to stress#GO:0006950;positive regulation of autophagy#GO:0010508;autophagy#GO:0006914;cellular component assembly#GO:0022607;regulation of multicellular organismal process#GO:0051239;positive regulation of metabolic process#GO:0009893;cellular component organization#GO:0016043;defense response to virus#GO:0051607;positive regulation of macroautophagy#GO:0016239;biological process involved in interspecies interaction between organisms#GO:0044419;regulation of response to stress#GO:0080134;regulation of gene expression#GO:0010468;positive regulation of gene expression#GO:0010628;response to external stimulus#GO:0009605;regulation of macromolecule biosynthetic process#GO:0010556;reticulophagy#GO:0061709;activation of innate immune response#GO:0002218;positive regulation of innate immune response#GO:0045089;macroautophagy#GO:0016236;response to other organism#GO:0051707;organelle assembly#GO:0070925;positive regulation of biosynthetic process#GO:0009891;vacuole organization#GO:0007033;positive regulation of cytokine production#GO:0001819;catabolic process#GO:0009056;regulation of response to biotic stimulus#GO:0002831;response to external biotic stimulus#GO:0043207 membrane#GO:0016020;endomembrane system#GO:0012505;vacuole#GO:0005773;cytoplasm#GO:0005737;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;organelle membrane#GO:0031090;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;autophagosome#GO:0005776;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=5896|UniProtKB=P01715 P01715 IGLV3-1 PTHR23267:SF315 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN LAMBDA VARIABLE 3-1 response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 protein-containing complex#GO:0032991 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=11920|UniProtKB=P25445 P25445 FAS PTHR46874:SF1 TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6 TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6 death receptor activity#GO:0005035;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 multicellular organismal-level homeostasis#GO:0048871;negative regulation of cellular process#GO:0048523;regulation of response to stress#GO:0080134;regulation of response to stimulus#GO:0048583;multicellular organismal process#GO:0032501;negative regulation of apoptotic process#GO:0043066;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;necroptotic process#GO:0070266;cell communication#GO:0007154;homeostasis of number of cells#GO:0048872;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;homeostatic process#GO:0042592;programmed cell death#GO:0012501;cell death#GO:0008219;cellular response to stimulus#GO:0051716;regulation of apoptotic process#GO:0042981;regulation of MAPK cascade#GO:0043408;lymphocyte homeostasis#GO:0002260;cellular process#GO:0009987;signal transduction#GO:0007165;negative regulation of programmed cell death#GO:0043069;neuron apoptotic process#GO:0051402;regulation of cellular response to stress#GO:0080135;regulation of intracellular signal transduction#GO:1902531;immune system process#GO:0002376;regulation of signaling#GO:0023051;response to stimulus#GO:0050896;signaling#GO:0023052;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;apoptotic process#GO:0006915;regulation of biological process#GO:0050789 membrane microdomain#GO:0098857;external side of plasma membrane#GO:0009897;side of membrane#GO:0098552;membrane protein complex#GO:0098796;membrane raft#GO:0045121;membrane#GO:0016020;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 p53 pathway#P00059>FAS#G01571;FAS signaling pathway#P00020>Fas#P00612;Apoptosis signaling pathway#P00006>FAS#P00289 HUMAN|HGNC=7702|UniProtKB=P17568 P17568 NDUFB7 PTHR20900:SF0 NADH:UBIQUINONE OXIDOREDUCTASE B18-LIKE SUBUNIT NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 7 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;oxidoreductase complex#GO:1990204;membrane#GO:0016020;membrane protein complex#GO:0098796;respiratory chain complex#GO:0098803;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;respiratory chain complex I#GO:0045271;catalytic complex#GO:1902494 oxidoreductase#PC00176 HUMAN|HGNC=23099|UniProtKB=Q8N7R0 Q8N7R0 NANOGP1 PTHR24327:SF90 HOMEOBOX PROTEIN HOMEOBOX PROTEIN NANOG2-RELATED cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;stem cell population maintenance#GO:0019827;cellular process#GO:0009987;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;developmental process#GO:0032502;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;maintenance of cell number#GO:0098727;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 gene-specific transcriptional regulator#PC00264;helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=21373|UniProtKB=Q8N2I9 Q8N2I9 STK40 PTHR22961:SF16 SER/THR PROTEIN KINASE-TRB SERINE_THREONINE-PROTEIN KINASE 40 regulation of intracellular signal transduction#GO:1902531;regulation of MAPK cascade#GO:0043408;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cell communication#GO:0010646;regulation of biological process#GO:0050789 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=15789|UniProtKB=P53582 P53582 METAP1 PTHR43330:SF7 METHIONINE AMINOPEPTIDASE METHIONINE AMINOPEPTIDASE 1 metallopeptidase activity#GO:0008237;exopeptidase activity#GO:0008238;hydrolase activity#GO:0016787;metalloaminopeptidase activity#GO:0070006;metalloexopeptidase activity#GO:0008235;catalytic activity#GO:0003824;aminopeptidase activity#GO:0004177;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 metalloprotease#PC00153 HUMAN|HGNC=2084|UniProtKB=Q16740 Q16740 CLPP PTHR10381:SF11 ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT, MITOCHONDRIAL serine-type peptidase activity#GO:0008236;binding#GO:0005488;enzyme binding#GO:0019899;ATP-dependent activity#GO:0140657;hydrolase activity#GO:0016787;protein binding#GO:0005515;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;protein quality control for misfolded or incompletely synthesized proteins#GO:0006515;catabolic process#GO:0009056;primary metabolic process#GO:0044238;cellular process#GO:0009987 protein-containing complex#GO:0032991;catalytic complex#GO:1902494 serine protease#PC00203 HUMAN|HGNC=23578|UniProtKB=Q9H8M7 Q9H8M7 MINDY3 PTHR12473:SF17 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MINDY-4-RELATED UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MINDY-3 hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;catalytic activity#GO:0003824;deubiquitinase activity#GO:0101005 HUMAN|HGNC=10582|UniProtKB=Q9Y5Y9 Q9Y5Y9 SCN10A PTHR10037:SF208 VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM SODIUM CHANNEL PROTEIN TYPE 10 SUBUNIT ALPHA monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;transporter activity#GO:0005215;sodium channel activity#GO:0005272;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;voltage-gated sodium channel activity#GO:0005248;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261 cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;regulation of multicellular organismal process#GO:0051239;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transmembrane transport#GO:0098655;multicellular organismal process#GO:0032501;transport#GO:0006810;regulation of system process#GO:0044057;system process#GO:0003008;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;sodium ion transport#GO:0006814;regulation of biological process#GO:0050789;action potential#GO:0001508;sensory perception of pain#GO:0019233;regulation of heart contraction#GO:0008016;membrane depolarization#GO:0051899;metal ion transport#GO:0030001;regulation of cellular process#GO:0050794;nervous system process#GO:0050877;sensory perception#GO:0007600;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179 neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;cation channel complex#GO:0034703;transporter complex#GO:1990351;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165;axon#GO:0030424;sodium channel complex#GO:0034706;transmembrane transporter complex#GO:1902495 voltage-gated ion channel#PC00241 HUMAN|HGNC=14628|UniProtKB=Q9BWT1 Q9BWT1 CDCA7 PTHR31169:SF2 OS05G0300700 PROTEIN CELL DIVISION CYCLE-ASSOCIATED PROTEIN 7 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=9756|UniProtKB=O00391 O00391 QSOX1 PTHR22897:SF6 QUIESCIN Q6-RELATED SULFHYDRYL OXIDASE SULFHYDRYL OXIDASE 1 oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;protein-disulfide reductase activity#GO:0015035;catalytic activity#GO:0003824;protein disulfide isomerase activity#GO:0003756;oxidoreductase activity#GO:0016491;catalytic activity, acting on a protein#GO:0140096;intramolecular oxidoreductase activity#GO:0016860;disulfide oxidoreductase activity#GO:0015036;isomerase activity#GO:0016853 cellular component organization#GO:0016043;primary metabolic process#GO:0044238;protein folding#GO:0006457;extracellular structure organization#GO:0043062;extracellular matrix organization#GO:0030198;protein metabolic process#GO:0019538;external encapsulating structure organization#GO:0045229;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;extracellular matrix assembly#GO:0085029;protein maturation#GO:0051604;gene expression#GO:0010467;cellular component assembly#GO:0022607;biosynthetic process#GO:0009058;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 oxidase#PC00175;oxidoreductase#PC00176 HUMAN|HGNC=32251|UniProtKB=A0A8V8TPE2 A0A8V8TPE2 FAM90A3 PTHR16035:SF14 PROTEIN FAM90A1 PROTEIN FAM90A10-RELATED HUMAN|HGNC=14513|UniProtKB=Q9Y2Q9 Q9Y2Q9 MRPS28 PTHR13447:SF2 MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S28 SMALL RIBOSOMAL SUBUNIT PROTEIN BS1M structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 metabolic process#GO:0008152;translation#GO:0006412;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;mitochondrial gene expression#GO:0140053;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mitochondrial translation#GO:0032543;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;mitochondrion#GO:0005739;organelle lumen#GO:0043233;mitochondrial ribosome#GO:0005761;intracellular anatomical structure#GO:0005622;organellar ribosome#GO:0000313;membrane-bounded organelle#GO:0043227;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;small ribosomal subunit#GO:0015935;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;membrane-enclosed lumen#GO:0031974;mitochondrial small ribosomal subunit#GO:0005763;membraneless organelle#GO:0043228 ribosomal protein#PC00202;translational protein#PC00263 HUMAN|HGNC=33743|UniProtKB=Q5JRM2 Q5JRM2 CXorf66 PTHR37340:SF1 GENE 7073-RELATED GENE 7073-RELATED HUMAN|HGNC=6199|UniProtKB=O75564 O75564 JRK PTHR19303:SF11 TRANSPOSON JERKY PROTEIN HOMOLOG binding#GO:0005488;nucleic acid binding#GO:0003676;DNA binding#GO:0003677 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 viral or transposable element protein#PC00237 HUMAN|HGNC=25524|UniProtKB=Q96PV7 Q96PV7 FAM193B PTHR15109:SF3 AGAP004327-PA PROTEIN FAM193B intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=9291|UniProtKB=Q16821 Q16821 PPP1R3A PTHR12307:SF2 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 3A enzyme binding#GO:0019899;phosphatase binding#GO:0019902;polysaccharide binding#GO:0030247;binding#GO:0005488;protein phosphatase binding#GO:0019903;protein binding#GO:0005515;carbohydrate binding#GO:0030246 regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of carbohydrate biosynthetic process#GO:0043255;regulation of polysaccharide metabolic process#GO:0032881;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of glycogen biosynthetic process#GO:0005979;regulation of carbohydrate metabolic process#GO:0006109;regulation of biosynthetic process#GO:0009889;regulation of polysaccharide biosynthetic process#GO:0032885 catalytic complex#GO:1902494;protein serine/threonine phosphatase complex#GO:0008287;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 protein-binding activity modulator#PC00095;phosphatase modulator#PC00184 HUMAN|HGNC=25460|UniProtKB=Q96I82 Q96I82 KAZALD1 PTHR14186:SF21 INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-RELATED KAZAL-TYPE SERINE PROTEASE INHIBITOR DOMAIN-CONTAINING PROTEIN 1 molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545 regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;regulation of biological process#GO:0050789;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583 extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;interstitial matrix#GO:0005614;cellular anatomical structure#GO:0110165 HUMAN|HGNC=19081|UniProtKB=Q9C0C2 Q9C0C2 TNKS1BP1 PTHR22042:SF2 TANKYRASE 1 BINDING PROTEIN 182 KDA TANKYRASE-1-BINDING PROTEIN cellular process#GO:0009987;response to radiation#GO:0009314;response to stress#GO:0006950;nucleobase-containing compound metabolic process#GO:0006139;DNA damage response#GO:0006974;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;cellular response to abiotic stimulus#GO:0071214;response to ionizing radiation#GO:0010212;cellular response to stimulus#GO:0051716;response to abiotic stimulus#GO:0009628;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular response to radiation#GO:0071478;response to stimulus#GO:0050896;cellular response to environmental stimulus#GO:0104004;cellular response to stress#GO:0033554 chromatin#GO:0000785;nucleus#GO:0005634;CCR4-NOT complex#GO:0030014;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;heterochromatin#GO:0000792 HUMAN|HGNC=11216|UniProtKB=O75391 O75391 SPAG7 PTHR13498:SF3 SPERM ASSOCIATED ANTIGEN 7 SPERM-ASSOCIATED ANTIGEN 7 DNA metabolism protein#PC00009 HUMAN|HGNC=2979|UniProtKB=Q9UBC3 Q9UBC3 DNMT3B PTHR23068:SF9 DNA CYTOSINE-5- -METHYLTRANSFERASE 3-RELATED DNA (CYTOSINE-5)-METHYLTRANSFERASE 3B methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA binding#GO:0003677;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on DNA#GO:0140097 negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA methyltransferase#PC00013 HUMAN|HGNC=7715|UniProtKB=O00217 O00217 NDUFS8 PTHR10849:SF20 NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 8, MITOCHONDRIAL NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 8, MITOCHONDRIAL catalytic activity#GO:0003824;NADH dehydrogenase activity#GO:0003954;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on NAD(P)H#GO:0016651 electron transport chain#GO:0022900;respiratory electron transport chain#GO:0022904;cellular process#GO:0009987;mitochondrial ATP synthesis coupled electron transport#GO:0042775;aerobic electron transport chain#GO:0019646;metabolic process#GO:0008152;mitochondrial electron transport, NADH to ubiquinone#GO:0006120;generation of precursor metabolites and energy#GO:0006091;cellular respiration#GO:0045333;energy derivation by oxidation of organic compounds#GO:0015980;oxidative phosphorylation#GO:0006119;ATP synthesis coupled electron transport#GO:0042773;aerobic respiration#GO:0009060 oxidoreductase complex#GO:1990204;membrane#GO:0016020;membrane protein complex#GO:0098796;respiratory chain complex#GO:0098803;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;respiratory chain complex I#GO:0045271;catalytic complex#GO:1902494;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HUMAN|HGNC=27845|UniProtKB=Q5JUK2 Q5JUK2 SOHLH1 PTHR46665:SF1 TRANSCRIPTION FACTOR BHLH041-RELATED-RELATED SPERMATOGENESIS- AND OOGENESIS-SPECIFIC BASIC HELIX-LOOP-HELIX-CONTAINING PROTEIN 1 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=12556|UniProtKB=Q96T88 Q96T88 UHRF1 PTHR14140:SF2 E3 UBIQUITIN-PROTEIN LIGASE UHRF-RELATED E3 UBIQUITIN-PROTEIN LIGASE UHRF1 ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;protein modification process#GO:0036211;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;post-translational protein modification#GO:0043687;chromatin organization#GO:0006325;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;epigenetic regulation of gene expression#GO:0040029;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;negative regulation of cellular process#GO:0048523;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;protein modification by small protein conjugation#GO:0032446;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;protein modification by small protein conjugation or removal#GO:0070647;protein ubiquitination#GO:0016567;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of gene expression, epigenetic#GO:0045814;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=14329|UniProtKB=Q9NS25 Q9NS25 SPANXB1 PTHR23425:SF16 NUCLEOPORIN AMO1-LIKE SPERM PROTEIN ASSOCIATED WITH THE NUCLEUS ON THE X CHROMOSOME A-RELATED transporter#PC00227 HUMAN|HGNC=26057|UniProtKB=Q9NWW6 Q9NWW6 NMRK1 PTHR10285:SF126 URIDINE KINASE NICOTINAMIDE RIBOSIDE KINASE 1 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 nucleotide kinase#PC00172;kinase#PC00137 HUMAN|HGNC=13012|UniProtKB=P17026 P17026 ZNF22 PTHR16515:SF71 PR DOMAIN ZINC FINGER PROTEIN ZINC FINGER PROTEIN 22 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HUMAN|HGNC=18373|UniProtKB=Q8TD17 Q8TD17 ZNF398 PTHR24381:SF269 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 398 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=165|UniProtKB=Q08043 Q08043 ACTN3 PTHR11915:SF432 SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN ALPHA-ACTININ-3 actin binding#GO:0003779;actin filament binding#GO:0051015;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 cytoskeleton organization#GO:0007010;cellular process#GO:0009987;organelle organization#GO:0006996;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;developmental process#GO:0032502;cell development#GO:0048468;muscle structure development#GO:0061061;actin cytoskeleton organization#GO:0030036;cell differentiation#GO:0030154;muscle cell differentiation#GO:0042692;cellular component organization#GO:0016043;muscle cell development#GO:0055001;anatomical structure development#GO:0048856;actin filament-based process#GO:0030029;animal gross anatomical part developmental process#GO:0160108 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;actin cytoskeleton#GO:0015629;cortical cytoskeleton#GO:0030863;cell cortex#GO:0005938;myofibril#GO:0030016;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;cortical actin cytoskeleton#GO:0030864;cytoplasm#GO:0005737;membrane#GO:0016020;contractile muscle fiber#GO:0043292;Z disc#GO:0030018;cell periphery#GO:0071944;sarcomere#GO:0030017;cell junction#GO:0030054;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;I band#GO:0031674 actin or actin-binding cytoskeletal protein#PC00041 Integrin signalling pathway#P00034>alpha actinin#P00928 HUMAN|HGNC=5320|UniProtKB=Q12794 Q12794 HYAL1 PTHR11769:SF23 HYALURONIDASE HYALURONIDASE-1 macromolecule metabolic process#GO:0043170;aminoglycan catabolic process#GO:0006026;glycosaminoglycan catabolic process#GO:0006027;metabolic process#GO:0008152;aminoglycan metabolic process#GO:0006022;macromolecule catabolic process#GO:0009057;carbohydrate derivative catabolic process#GO:1901136;catabolic process#GO:0009056;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;glycosaminoglycan metabolic process#GO:0030203 vesicle#GO:0031982;intracellular vesicle#GO:0097708;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 glycosidase#PC00110 HUMAN|HGNC=1774|UniProtKB=Q00535 Q00535 CDK5 PTHR24056:SF594 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE 5 cyclin-dependent protein serine/threonine kinase activity#GO:0004693;protein serine/threonine kinase activity#GO:0004674;cyclin-dependent protein kinase activity#GO:0097472;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;neuron apoptotic process#GO:0051402;cellular localization#GO:0051641;axonogenesis#GO:0007409;neuron development#GO:0048666;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;apoptotic process#GO:0006915;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell morphogenesis#GO:0000902;establishment of organelle localization#GO:0051656;cell development#GO:0048468;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cell projection morphogenesis#GO:0048858;neuron projection development#GO:0031175;synaptic vesicle transport#GO:0048489;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;synaptic vesicle localization#GO:0097479;establishment of vesicle localization#GO:0051650;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;organelle localization#GO:0051640;localization#GO:0051179;anatomical structure development#GO:0048856;system development#GO:0048731;programmed cell death#GO:0012501;cell death#GO:0008219;developmental process#GO:0032502;transport#GO:0006810;neuron projection morphogenesis#GO:0048812;establishment of localization#GO:0051234;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;axon development#GO:0061564;vesicle localization#GO:0051648;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036 nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex#GO:1990234;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;protein kinase complex#GO:1902911;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 Axon guidance mediated by semaphorins#P00007>Cdk5#P00336;Dopamine receptor mediated signaling pathway#P05912>CDK5#P05951;Nicotine pharmacodynamics pathway#P06587>CDK5#P06597;PDGF signaling pathway#P00047>GSK3#P01153;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>GSK-3#P00902 HUMAN|HGNC=30182|UniProtKB=Q9BYX7 Q9BYX7 POTEKP PTHR11937:SF278 ACTIN BETA-ACTIN-LIKE PROTEIN 3-RELATED structural molecule activity#GO:0005198;binding#GO:0005488;kinase binding#GO:0019900;structural constituent of cytoskeleton#GO:0005200;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;protein binding#GO:0005515;structural constituent of synapse#GO:0098918 system development#GO:0048731;neuron development#GO:0048666;axonogenesis#GO:0007409;anatomical structure development#GO:0048856;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell motility#GO:0048870;cell morphogenesis#GO:0000902;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;cell projection morphogenesis#GO:0048858;neurogenesis#GO:0022008;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;developmental process#GO:0032502;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron projection morphogenesis#GO:0048812;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cell morphogenesis involved in neuron differentiation#GO:0048667;multicellular organismal process#GO:0032501;cellular process#GO:0009987;neuron projection development#GO:0031175;axon development#GO:0061564 intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;axon#GO:0030424;plasma membrane bounded cell projection#GO:0120025;chromosome#GO:0005694;intracellular protein-containing complex#GO:0140535;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;transferase complex#GO:1990234;cytoskeleton#GO:0005856;H4 histone acetyltransferase complex#GO:1902562;membrane#GO:0016020;acetyltransferase complex#GO:1902493;supramolecular fiber#GO:0099512;protein acetyltransferase complex#GO:0031248;intracellular organelle#GO:0043229;cell projection#GO:0042995;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;actin cytoskeleton#GO:0015629;histone acetyltransferase complex#GO:0000123;cell junction#GO:0030054;actin filament#GO:0005884;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;NuA4 histone acetyltransferase complex#GO:0035267;supramolecular complex#GO:0099080;chromatin#GO:0000785;neuron projection#GO:0043005 actin and actin related protein#PC00039 HUMAN|HGNC=25360|UniProtKB=Q5T1V6 Q5T1V6 DDX59 PTHR47958:SF30 ATP-DEPENDENT RNA HELICASE DBP3 ATP-DEPENDENT RNA HELICASE DDX59-RELATED ATP-dependent activity#GO:0140657;mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;macromolecular conformation isomerase activity#GO:0120543;catalytic activity, acting on a nucleic acid#GO:0140640;RNA helicase activity#GO:0003724;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity#GO:0003824;catalytic activity, acting on RNA#GO:0140098;isomerase activity#GO:0016853;helicase activity#GO:0004386 RNA helicase#PC00032 HUMAN|HGNC=31009|UniProtKB=H0YL14 H0YL14 TMEM250 PTHR48431:SF1 TRANSMEMBRANE PROTEIN 250 TRANSMEMBRANE PROTEIN 250 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=3005|UniProtKB=O60762 O60762 DPM1 PTHR43398:SF1 DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1 DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1 catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758;glycosyltransferase activity#GO:0016757;mannosyltransferase activity#GO:0000030 metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;glycoprotein biosynthetic process#GO:0009101;protein N-linked glycosylation#GO:0006487;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;biosynthetic process#GO:0009058 endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;membrane#GO:0016020;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 glycosyltransferase#PC00111;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=30727|UniProtKB=Q9UNN4 Q9UNN4 GTF2A1L PTHR12694:SF9 TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1 TFIIA-ALPHA AND BETA-LIKE FACTOR DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;core promoter sequence-specific DNA binding#GO:0001046;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription coregulator activity#GO:0003712 DNA-templated transcription initiation#GO:0006352;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;transcription initiation at RNA polymerase II promoter#GO:0006367;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;transcription by RNA polymerase II#GO:0006366 organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;RNA polymerase II, holoenzyme#GO:0016591;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;membrane-bounded organelle#GO:0043227;RNA polymerase II transcription regulator complex#GO:0090575;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;transcription factor TFIID complex#GO:0005669;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;transcription regulator complex#GO:0005667 general transcription factor#PC00259 Transcription regulation by bZIP transcription factor#P00055>TFIIA complex#P01390;General transcription regulation#P00023>TFIIA complex#P00662 HUMAN|HGNC=2586|UniProtKB=Q9UDT6 Q9UDT6 CLIP2 PTHR18916:SF10 DYNACTIN 1-RELATED MICROTUBULE-BINDING CAP-GLY DOMAIN-CONTAINING LINKER PROTEIN 2 protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;microtubule binding#GO:0008017;binding#GO:0005488 cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;cytoplasmic microtubule organization#GO:0031122;microtubule-based process#GO:0007017;supramolecular fiber organization#GO:0097435;microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840 nucleus#GO:0005634;cell periphery#GO:0071944;microtubule cytoskeleton#GO:0015630;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;microtubule plus-end#GO:0035371;microtubule end#GO:1990752;cell cortex#GO:0005938;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membrane-bounded organelle#GO:0043227;microtubule#GO:0005874 chaperone#PC00072 HUMAN|HGNC=29594|UniProtKB=O14949 O14949 UQCRQ PTHR12119:SF2 UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX UBIQUINONE-BINDING PROTEIN QP-C CYTOCHROME B-C1 COMPLEX SUBUNIT 8 cellular process#GO:0009987;respiratory electron transport chain#GO:0022904;mitochondrial electron transport, ubiquinol to cytochrome c#GO:0006122;mitochondrial ATP synthesis coupled electron transport#GO:0042775;electron transport chain#GO:0022900;aerobic respiration#GO:0009060;cellular respiration#GO:0045333;energy derivation by oxidation of organic compounds#GO:0015980;oxidative phosphorylation#GO:0006119;ATP synthesis coupled electron transport#GO:0042773;generation of precursor metabolites and energy#GO:0006091;aerobic electron transport chain#GO:0019646;metabolic process#GO:0008152 respiratory chain complex III#GO:0045275;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;respiratory chain complex#GO:0098803;cytochrome complex#GO:0070069;membrane protein complex#GO:0098796;oxidoreductase complex#GO:1990204;membrane#GO:0016020 oxidoreductase#PC00176 HUMAN|HGNC=23467|UniProtKB=A6NIR3 A6NIR3 AGAP5 PTHR45819:SF7 CENTAURIN-GAMMA-1A ARF-GAP WITH GTPASE, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 4-RELATED hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;enzyme activator activity#GO:0008047;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;molecular function regulator activity#GO:0098772;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589 GTPase-activating protein#PC00257;G-protein modulator#PC00022 HUMAN|HGNC=10704|UniProtKB=O95487 O95487 SEC24B PTHR13803:SF42 SEC24-RELATED PROTEIN PROTEIN TRANSPORT PROTEIN SEC24B binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;transition metal ion binding#GO:0046914;metal ion binding#GO:0046872;protein binding#GO:0005515;cation binding#GO:0043169;zinc ion binding#GO:0008270;SNARE binding#GO:0000149 membrane organization#GO:0061024;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;organelle organization#GO:0006996;vesicle organization#GO:0016050;vesicle budding from membrane#GO:0006900;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;Golgi vesicle transport#GO:0048193;transport#GO:0006810;intracellular transport#GO:0046907;cellular component organization#GO:0016043;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;localization#GO:0051179;COPII-coated vesicle budding#GO:0090114 vesicle membrane#GO:0012506;membrane#GO:0016020;vesicle coat#GO:0030120;cytoplasm#GO:0005737;transport vesicle#GO:0030133;transport vesicle membrane#GO:0030658;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;ER to Golgi transport vesicle membrane#GO:0012507;endoplasmic reticulum exit site#GO:0070971;endoplasmic reticulum#GO:0005783;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;vesicle#GO:0031982;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;coated vesicle membrane#GO:0030662;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;coated vesicle#GO:0030135;coated membrane#GO:0048475;membrane coat#GO:0030117;COPII-coated ER to Golgi transport vesicle#GO:0030134 vesicle coat protein#PC00235 HUMAN|HGNC=26998|UniProtKB=Q6DD87 Q6DD87 ZNF787 PTHR24408:SF73 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 787 DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=29082|UniProtKB=O60347 O60347 TBC1D12 PTHR22957:SF467 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN TBC1 DOMAIN FAMILY MEMBER 12 enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 regulation of autophagosome assembly#GO:2000785;regulation of cellular component biogenesis#GO:0044087;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of organelle organization#GO:0033043;regulation of organelle assembly#GO:1902115;regulation of biological process#GO:0050789 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;vacuole#GO:0005773;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular vesicle#GO:0097708;vesicle#GO:0031982;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;recycling endosome#GO:0055037;autophagosome#GO:0005776;intracellular organelle#GO:0043229;endosome#GO:0005768 GTPase-activating protein#PC00257;protein-binding activity modulator#PC00095;G-protein modulator#PC00022 HUMAN|HGNC=26755|UniProtKB=Q8N1Q8 Q8N1Q8 THEM5 PTHR47362:SF1 ACYL-COENZYME A THIOESTERASE THEM5 ACYL-COENZYME A THIOESTERASE THEM5 thiolester hydrolase activity#GO:0016790;hydrolase activity, acting on ester bonds#GO:0016788;acyl-CoA hydrolase activity#GO:0016289;catalytic activity#GO:0003824;fatty acyl-CoA hydrolase activity#GO:0047617;deacylase activity#GO:0160215;hydrolase activity#GO:0016787 small molecule metabolic process#GO:0044281;nucleobase-containing compound metabolic process#GO:0006139;nucleoside phosphate metabolic process#GO:0006753;organophosphate metabolic process#GO:0019637;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;sulfur compound metabolic process#GO:0006790;purine-containing compound metabolic process#GO:0072521;cellular process#GO:0009987;acyl-CoA metabolic process#GO:0006637;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;lipid metabolic process#GO:0006629 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;mitochondrion#GO:0005739 hydrolase#PC00121;esterase#PC00097 HUMAN|HGNC=4823|UniProtKB=P69905 P69905 HBA1 PTHR11442:SF48 HEMOGLOBIN FAMILY MEMBER HEMOGLOBIN SUBUNIT ALPHA tetrapyrrole binding#GO:0046906;heme binding#GO:0020037;molecular carrier activity#GO:0140104;binding#GO:0005488 cellular developmental process#GO:0048869;establishment of localization#GO:0051234;multicellular organismal-level homeostasis#GO:0048871;transport#GO:0006810;developmental process#GO:0032502;multicellular organismal process#GO:0032501;hemopoiesis#GO:0030097;cellular process#GO:0009987;erythrocyte differentiation#GO:0030218;anatomical structure development#GO:0048856;localization#GO:0051179;immune system process#GO:0002376;homeostasis of number of cells#GO:0048872;myeloid cell differentiation#GO:0030099;cell differentiation#GO:0030154;cell development#GO:0048468;homeostatic process#GO:0042592 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 globin#PC00107;transfer/carrier protein#PC00219 HUMAN|HGNC=25824|UniProtKB=Q6ZW31 Q6ZW31 SYDE1 PTHR46150:SF2 RHO GTPASE-ACTIVATING PROTEIN 100F RHO GTPASE-ACTIVATING PROTEIN SYDE1 GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047 regulation of biological process#GO:0050789;cellular process#GO:0009987;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;cell migration#GO:0016477;cell motility#GO:0048870;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;regulation of small GTPase mediated signal transduction#GO:0051056;regulation of Ras protein signal transduction#GO:0046578 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;synapse#GO:0045202;plasma membrane region#GO:0098590;synaptic membrane#GO:0097060;cell junction#GO:0030054 protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HUMAN|HGNC=17556|UniProtKB=Q9Y2X0 Q9Y2X0 MED16 PTHR13224:SF6 THYROID HORMONE RECEPTOR-ASSOCIATED PROTEIN-RELATED MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 16 transcription coactivator activity#GO:0003713;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789;regulation of DNA-templated transcription initiation#GO:2000142;regulation of DNA-templated transcription#GO:0006355;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of transcription by RNA polymerase II#GO:0045944 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;mediator complex#GO:0016592;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513 HUMAN|HGNC=20396|UniProtKB=Q9UKJ1 Q9UKJ1 PILRA PTHR15549:SF26 PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR ALPHA-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=26372|UniProtKB=Q8N0W7 Q8N0W7 FMR1NB PTHR37360:SF1 FRAGILE X MENTAL RETARDATION 1 NEIGHBOR PROTEIN FMR1 NEIGHBOR PROTEIN HUMAN|HGNC=12312|UniProtKB=Q15651 Q15651 HMGN3 PTHR23087:SF2 NONHISTONE CHROMOSOMAL PROTEIN HMG HIGH MOBILITY GROUP NUCLEOSOME-BINDING DOMAIN-CONTAINING PROTEIN 3 chromatin binding#GO:0003682;binding#GO:0005488 cellular process#GO:0009987;cellular component organization#GO:0016043;chromatin organization#GO:0006325;cellular component organization or biogenesis#GO:0071840 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=20263|UniProtKB=Q96T68 Q96T68 SETDB2 PTHR46024:SF3 HISTONE-LYSINE N-METHYLTRANSFERASE EGGLESS HISTONE-LYSINE N-METHYLTRANSFERASE SETDB2 N-methyltransferase activity#GO:0008170;histone methyltransferase activity#GO:0042054;protein-lysine N-methyltransferase activity#GO:0016279;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;histone modifying activity#GO:0140993;histone H3 methyltransferase activity#GO:0140938;lysine N-methyltransferase activity#GO:0016278;protein methyltransferase activity#GO:0008276;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of metabolic process#GO:0009892;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;heterochromatin organization#GO:0070828;chromatin organization#GO:0006325;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 histone modifying enzyme#PC00261 HUMAN|HGNC=4564|UniProtKB=Q13322 Q13322 GRB10 PTHR11243:SF4 GROWTH FACTOR RECEPTOR-BOUND PROTEIN GROWTH FACTOR RECEPTOR-BOUND PROTEIN 10 protein binding#GO:0005515;signaling adaptor activity#GO:0035591;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;signaling receptor complex adaptor activity#GO:0030159;signaling receptor binding#GO:0005102;binding#GO:0005488 biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;response to peptide hormone#GO:0043434;cellular response to nitrogen compound#GO:1901699;negative regulation of response to stimulus#GO:0048585;negative regulation of Wnt signaling pathway#GO:0030178;cellular response to insulin stimulus#GO:0032869;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;cellular response to stimulus#GO:0051716;response to insulin#GO:0032868;regulation of cell communication#GO:0010646;cellular response to peptide hormone stimulus#GO:0071375;regulation of cellular process#GO:0050794;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;response to nitrogen compound#GO:1901698;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987;response to hormone#GO:0009725;negative regulation of signal transduction#GO:0009968;response to chemical#GO:0042221;cell surface receptor signaling pathway#GO:0007166;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;response to endogenous stimulus#GO:0009719;signaling#GO:0023052;regulation of Wnt signaling pathway#GO:0030111;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;cellular response to hormone stimulus#GO:0032870;insulin receptor signaling pathway#GO:0008286;response to oxygen-containing compound#GO:1901700;regulation of signaling#GO:0023051;cellular response to chemical stimulus#GO:0070887;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648 scaffold/adaptor protein#PC00226 HUMAN|HGNC=4284|UniProtKB=P29033 P29033 GJB2 PTHR11984:SF46 CONNEXIN GAP JUNCTION BETA-2 PROTEIN wide pore channel activity#GO:0022829;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 anatomical structure development#GO:0048856;cell communication#GO:0007154;localization#GO:0051179;ear development#GO:0043583;animal gross anatomical part developmental process#GO:0160108;cell junction organization#GO:0034330;signaling#GO:0023052;cellular component organization#GO:0016043;cell junction assembly#GO:0034329;regulation of biological process#GO:0050789;establishment of localization#GO:0051234;animal organ development#GO:0048513;cellular component organization or biogenesis#GO:0071840;sensory organ development#GO:0007423;cell-cell junction assembly#GO:0007043;transport#GO:0006810;developmental process#GO:0032502;cell-cell junction organization#GO:0045216;cellular component assembly#GO:0022607;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;inner ear development#GO:0048839;cellular component biogenesis#GO:0044085;cellular process#GO:0009987 anchoring junction#GO:0070161;cell junction#GO:0030054;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;cell-cell junction#GO:0005911;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 cell junction protein#PC00070;gap junction#PC00105 HUMAN|HGNC=13378|UniProtKB=Q9GZW8 Q9GZW8 MS4A7 PTHR23320:SF8 MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 7 cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 cell periphery#GO:0071944;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;plasma membrane#GO:0005886;trans-Golgi network#GO:0005802;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622 transporter#PC00227 HUMAN|HGNC=3227|UniProtKB=P52799 P52799 EFNB2 PTHR11304:SF18 EPHRIN EPHRIN-B2 binding#GO:0005488;signaling receptor binding#GO:0005102;protein binding#GO:0005515 cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;system development#GO:0048731;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;cell communication#GO:0007154;ephrin receptor signaling pathway#GO:0048013;tube morphogenesis#GO:0035239;blood vessel development#GO:0001568;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;neurogenesis#GO:0022008;neuron projection guidance#GO:0097485;cellular developmental process#GO:0048869;axon guidance#GO:0007411;axon development#GO:0061564;tube development#GO:0035295;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;neuron development#GO:0048666;axonogenesis#GO:0007409;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;blood vessel morphogenesis#GO:0048514;cell development#GO:0048468;signaling#GO:0023052;cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;circulatory system development#GO:0072359;cell differentiation#GO:0030154;response to stimulus#GO:0050896;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell surface receptor signaling pathway#GO:0007166;neuron differentiation#GO:0030182;vasculature development#GO:0001944;cell projection morphogenesis#GO:0048858;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;signal transduction#GO:0007165;neuron projection development#GO:0031175;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399 synaptic membrane#GO:0097060;cell junction#GO:0030054;membrane#GO:0016020;presynapse#GO:0098793;cell periphery#GO:0071944;plasma membrane region#GO:0098590;glutamatergic synapse#GO:0098978;synapse#GO:0045202;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;presynaptic membrane#GO:0042734 intercellular signal molecule#PC00207;membrane-bound signaling molecule#PC00152 Angiogenesis#P00005>Eph#P00239 HUMAN|HGNC=2606|UniProtKB=O15528 O15528 CYP27B1 PTHR24291:SF3 CYTOCHROME P450 FAMILY 4 25-HYDROXYVITAMIN D-1 ALPHA HYDROXYLASE, MITOCHONDRIAL monooxygenase activity#GO:0004497;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;oxidoreductase activity#GO:0016491 steroid biosynthetic process#GO:0006694;vitamin D metabolic process#GO:0042359;metabolic process#GO:0008152;alcohol metabolic process#GO:0006066;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;response to chemical#GO:0042221;lipid biosynthetic process#GO:0008610;response to lipid#GO:0033993;steroid metabolic process#GO:0008202;biosynthetic process#GO:0009058;response to nutrient levels#GO:0031667;alcohol biosynthetic process#GO:0046165;lipid catabolic process#GO:0016042;cellular process#GO:0009987;steroid catabolic process#GO:0006706;response to oxygen-containing compound#GO:1901700;response to stimulus#GO:0050896;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;small molecule catabolic process#GO:0044282;primary metabolic process#GO:0044238 mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 oxidoreductase#PC00176;oxygenase#PC00177;metabolite interconversion enzyme#PC00262 Vitamin D metabolism and pathway#P04396>1alpha-Hydroxylase#P04603;Vitamin D metabolism and pathway#P04396>25-Hydroxylase#P04601 HUMAN|HGNC=37182|UniProtKB=Q7RTZ2 Q7RTZ2 USP17L1 PTHR24006:SF651 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE INACTIVE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 17-LIKE PROTEIN 4-RELATED deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787;cysteine-type peptidase activity#GO:0008234;cysteine-type deubiquitinase activity#GO:0004843;catalytic activity#GO:0003824;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity, acting on a protein#GO:0140096 biological regulation#GO:0065007;regulation of biological quality#GO:0065008;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of protein stability#GO:0031647;regulation of apoptotic process#GO:0042981;regulation of programmed cell death#GO:0043067 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;cytosol#GO:0005829;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 cysteine protease#PC00081;protease#PC00190 HUMAN|HGNC=14986|UniProtKB=O60641 O60641 SNAP91 PTHR22951:SF4 CLATHRIN ASSEMBLY PROTEIN CLATHRIN COAT ASSEMBLY PROTEIN AP180 phosphatidylinositol phosphate binding#GO:1901981;phospholipid binding#GO:0005543;clathrin binding#GO:0030276;SNARE binding#GO:0000149;phosphatidylinositol bisphosphate binding#GO:1902936;protein binding#GO:0005515;lipid binding#GO:0008289;binding#GO:0005488;small molecule binding#GO:0036094;anion binding#GO:0043168;ion binding#GO:0043167;phosphatidylinositol-4,5-bisphosphate binding#GO:0005546 vesicle-mediated transport#GO:0016192;endocytosis#GO:0006897;membrane organization#GO:0061024;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;clathrin-dependent endocytosis#GO:0072583;cellular component organization or biogenesis#GO:0071840;localization#GO:0051179;import into cell#GO:0098657;establishment of localization#GO:0051234;receptor-mediated endocytosis#GO:0006898;vesicle budding from membrane#GO:0006900;vesicle organization#GO:0016050;transport#GO:0006810 clathrin-coated vesicle#GO:0030136;synaptic membrane#GO:0097060;extrinsic component of plasma membrane#GO:0019897;extrinsic component of membrane#GO:0019898;cell junction#GO:0030054;secretory vesicle#GO:0099503;membrane#GO:0016020;cell periphery#GO:0071944;presynapse#GO:0098793;endomembrane system#GO:0012505;plasma membrane region#GO:0098590;transport vesicle#GO:0030133;cytoplasm#GO:0005737;presynaptic membrane#GO:0042734;plasma membrane#GO:0005886;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;coated vesicle#GO:0030135;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;clathrin-coated pit#GO:0005905;intracellular vesicle#GO:0097708;synaptic vesicle#GO:0008021;vesicle#GO:0031982;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 vesicle coat protein#PC00235 HUMAN|HGNC=18145|UniProtKB=Q8IWS0 Q8IWS0 PHF6 PTHR12420:SF15 PHD FINGER PROTEIN PHD FINGER PROTEIN 6 binding#GO:0005488;histone binding#GO:0042393;enzyme binding#GO:0019899;protein binding#GO:0005515;histone deacetylase binding#GO:0042826 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA metabolism protein#PC00009 HUMAN|HGNC=3260|UniProtKB=Q9UI10 Q9UI10 EIF2B4 PTHR10233:SF14 TRANSLATION INITIATION FACTOR EIF-2B TRANSLATION INITIATION FACTOR EIF2B SUBUNIT DELTA translation initiation factor activity#GO:0003743;translation factor activity#GO:0180051 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;translational initiation#GO:0006413;translation#GO:0006412;metabolic process#GO:0008152;cytoplasmic translational initiation#GO:0002183;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;cytoplasmic translation#GO:0002181;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;guanyl-nucleotide exchange factor complex#GO:0032045;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535 translation factor#PC00223;translation initiation factor#PC00224 HUMAN|HGNC=30272|UniProtKB=Q53S08 Q53S08 RAB6D PTHR24073:SF1089 DRAB5-RELATED RAS-RELATED PROTEIN RAB-6A-RELATED hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111 protein localization to organelle#GO:0033365;cytosolic transport#GO:0016482;protein localization to membrane#GO:0072657;intra-Golgi vesicle-mediated transport#GO:0006891;localization#GO:0051179;cellular localization#GO:0051641;protein transport#GO:0015031;localization within membrane#GO:0051668;vesicle-mediated transport#GO:0016192;retrograde transport, endosome to Golgi#GO:0042147;macromolecule localization#GO:0033036;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;establishment of localization#GO:0051234;endosomal transport#GO:0016197;intracellular protein localization#GO:0008104;protein localization to Golgi apparatus#GO:0034067;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;Golgi vesicle transport#GO:0048193;transport#GO:0006810 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 G-protein#PC00020;small GTPase#PC00208 HUMAN|HGNC=2445|UniProtKB=P47710 P47710 CSN1S1 PTHR10240:SF0 ALPHA-S1-CASEIN ALPHA-S1-CASEIN response to estradiol#GO:0032355;response to stimulus#GO:0050896;response to alcohol#GO:0097305;response to chemical#GO:0042221;response to lipid#GO:0033993;response to endogenous stimulus#GO:0009719;response to hormone#GO:0009725;response to oxygen-containing compound#GO:1901700;response to steroid hormone#GO:0048545 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 storage protein#PC00210 HUMAN|HGNC=6026|UniProtKB=P25024 P25024 CXCR1 PTHR10489:SF916 CELL ADHESION MOLECULE C-X-C CHEMOKINE RECEPTOR TYPE 1 transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488;molecular transducer activity#GO:0060089;protein binding#GO:0005515;cytokine receptor activity#GO:0004896;signaling receptor activity#GO:0038023;cytokine binding#GO:0019955;immune receptor activity#GO:0140375;G protein-coupled receptor activity#GO:0004930 cell chemotaxis#GO:0060326;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;chemotaxis#GO:0006935;locomotion#GO:0040011;cell motility#GO:0048870;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;myeloid leukocyte migration#GO:0097529;response to external stimulus#GO:0009605;calcium-mediated signaling#GO:0019722;leukocyte chemotaxis#GO:0030595;leukocyte migration#GO:0050900;biological regulation#GO:0065007;cell migration#GO:0016477;immune response#GO:0006955;regulation of biological quality#GO:0065008;positive regulation of cytosolic calcium ion concentration#GO:0007204;immune system process#GO:0002376;cellular response to chemical stimulus#GO:0070887;signaling#GO:0023052;granulocyte chemotaxis#GO:0071621;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;neutrophil chemotaxis#GO:0030593;intracellular signaling cassette#GO:0141124;taxis#GO:0042330;response to chemical#GO:0042221;neutrophil migration#GO:1990266;granulocyte migration#GO:0097530;signal transduction#GO:0007165;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cell adhesion molecule#PC00069 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CHKR#P00854;Interleukin signaling pathway#P00036>Receptor subunit alpha#P00992 HUMAN|HGNC=20498|UniProtKB=Q7Z3D6 Q7Z3D6 DGLUCY PTHR32022:SF10 D-GLUTAMATE CYCLASE, MITOCHONDRIAL D-GLUTAMATE CYCLASE, MITOCHONDRIAL cyclase activity#GO:0009975;catalytic activity#GO:0003824;hydro-lyase activity#GO:0016836;carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829 cellular process#GO:0009987;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;amino acid metabolic process#GO:0006520;small molecule metabolic process#GO:0044281 cyclase#PC00079;lyase#PC00144 HUMAN|HGNC=28418|UniProtKB=Q5T5D7 Q5T5D7 ZNF684 PTHR24381:SF0 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 684 DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=2743|UniProtKB=Q9UHI6 Q9UHI6 DDX20 PTHR47958:SF89 ATP-DEPENDENT RNA HELICASE DBP3 ATP-DEPENDENT RNA HELICASE DDX20-RELATED catalytic activity#GO:0003824;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;RNA helicase activity#GO:0003724;macromolecular conformation isomerase activity#GO:0120543;helicase activity#GO:0004386;catalytic activity, acting on RNA#GO:0140098;isomerase activity#GO:0016853;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;ATP-dependent activity#GO:0140657;RNA binding#GO:0003723 cellular component assembly#GO:0022607;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;cellular component biogenesis#GO:0044085;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-RNA complex organization#GO:0071826;protein-containing complex organization#GO:0043933;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;spliceosomal snRNP assembly#GO:0000387;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;protein-containing complex assembly#GO:0065003;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;protein-RNA complex assembly#GO:0022618;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187 SMN complex#GO:0032797;SMN-Sm protein complex#GO:0034719;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;Sm-like protein family complex#GO:0120114;protein-containing complex#GO:0032991 RNA helicase#PC00032 HUMAN|HGNC=25754|UniProtKB=Q9H9H4 Q9H9H4 VPS37B PTHR13678:SF9 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37B modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein transport#GO:0015031;cellular localization#GO:0051641;protein targeting#GO:0006605;establishment of protein localization to vacuole#GO:0072666;intracellular protein transport#GO:0006886;macromolecule catabolic process#GO:0009057;protein targeting to membrane#GO:0006612;metabolic process#GO:0008152;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;protein targeting to vacuole#GO:0006623;establishment of protein localization to membrane#GO:0090150;localization within membrane#GO:0051668;protein localization to vacuole#GO:0072665;protein metabolic process#GO:0019538;localization#GO:0051179;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;protein localization to organelle#GO:0033365;catabolic process#GO:0009056;transport#GO:0006810;vacuolar transport#GO:0007034;intracellular transport#GO:0046907;ubiquitin-dependent protein catabolic process#GO:0006511;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;macromolecule metabolic process#GO:0043170;macromolecule localization#GO:0033036;ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043162 bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;vesicle membrane#GO:0012506;ESCRT I complex#GO:0000813;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endosome#GO:0005768;endosome membrane#GO:0010008;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;vesicle#GO:0031982 membrane trafficking regulatory protein#PC00151 HUMAN|Ensembl=ENSG00000278414.5|UniProtKB=A0A0G2JN68 A0A0G2JN68 KIR2DL5B PTHR11738:SF113 MHC CLASS I NK CELL RECEPTOR KILLER CELL IMMUNOGLOBULIN-LIKE RECEPTOR 2DL5A-RELATED immune receptor activity#GO:0140375;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;regulation of biological process#GO:0050789;immune response-regulating signaling pathway#GO:0002764;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;biological regulation#GO:0065007;signaling#GO:0023052;immune response-regulating cell surface receptor signaling pathway#GO:0002768;regulation of immune response#GO:0050776;regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=8940|UniProtKB=O14832 O14832 PHYH PTHR21308:SF1 PHYTANOYL-COA ALPHA-HYDROXYLASE PHYTANOYL-COA DIOXYGENASE, PEROXISOMAL catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;oxidoreductase activity#GO:0016491;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;dioxygenase activity#GO:0051213 carboxylic acid catabolic process#GO:0046395;lipid catabolic process#GO:0016042;cellular process#GO:0009987;monocarboxylic acid catabolic process#GO:0072329;fatty acid oxidation#GO:0019395;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;lipid modification#GO:0030258;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;small molecule catabolic process#GO:0044282;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;oxoacid metabolic process#GO:0043436;fatty acid catabolic process#GO:0009062;lipid oxidation#GO:0034440 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;peroxisome#GO:0005777;microbody#GO:0042579;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 metabolite interconversion enzyme#PC00262;hydroxylase#PC00122 HUMAN|HGNC=6856|UniProtKB=Q9Y6R4 Q9Y6R4 MAP3K4 PTHR48016:SF32 MAP KINASE KINASE KINASE SSK2-RELATED-RELATED MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4 signaling#GO:0023052;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124;p38MAPK cascade#GO:0038066;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;MAPK cascade#GO:0000165 non-receptor serine/threonine protein kinase#PC00167 Gonadotropin-releasing hormone receptor pathway#P06664>MAP3Ks#P06834;Oxidative stress response#P00046>MKK4#P01138;p38 MAPK pathway#P05918>MEKK4#P06026;FGF signaling pathway#P00021>MEKK1-5#P00634;Integrin signalling pathway#P00034>ERK#P00907;Interleukin signaling pathway#P00036>MEK#P00984;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>MEK#P00864;Ras Pathway#P04393>MEKK1/4#P04543;PDGF signaling pathway#P00047>ERK#P01143;EGF receptor signaling pathway#P00018>MEKK1-5#P00553 HUMAN|HGNC=15329|UniProtKB=Q8NGE5 Q8NGE5 OR10A7 PTHR26453:SF22 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 10A7 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;response to stimulus#GO:0050896;response to chemical#GO:0042221;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;detection of chemical stimulus#GO:0009593;system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;nervous system process#GO:0050877;sensory perception#GO:0007600 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=1621|UniProtKB=Q92526 Q92526 CCT6B PTHR11353:SF58 CHAPERONIN T-COMPLEX PROTEIN 1 SUBUNIT ZETA-2-RELATED cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;protein folding#GO:0006457;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;cytosol#GO:0005829;chaperonin-containing T-complex#GO:0005832;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;protein folding chaperone complex#GO:0101031 chaperonin#PC00073 HUMAN|HGNC=10405|UniProtKB=P60866 P60866 RPS20 PTHR11700:SF8 30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER SMALL RIBOSOMAL SUBUNIT PROTEIN US10 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 intracellular organelle#GO:0043229;small ribosomal subunit#GO:0015935;ribonucleoprotein complex#GO:1990904;cytosolic small ribosomal subunit#GO:0022627;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;ribosome#GO:0005840;cytosol#GO:0005829;cytosolic ribosome#GO:0022626;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 ribosomal protein#PC00202 HUMAN|HGNC=49205|UniProtKB=B7ZC32 B7ZC32 KIF28P PTHR24115:SF344 KINESIN-RELATED KINESIN-LIKE PROTEIN KIF28P cytoskeletal motor activity#GO:0003774;hydrolase activity, acting on acid anhydrides#GO:0016817;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;ATP-dependent activity#GO:0140657;isomerase activity#GO:0016853;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543;tubulin binding#GO:0015631;hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887;microtubule motor activity#GO:0003777;microtubule binding#GO:0008017;polypeptide conformation or assembly isomerase activity#GO:0120544 microtubule-based process#GO:0007017;vesicle cytoskeletal trafficking#GO:0099518;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;transport#GO:0006810;vesicle transport along microtubule#GO:0047496;intracellular transport#GO:0046907;organelle transport along microtubule#GO:0072384;establishment of vesicle localization#GO:0051650;cytoskeleton-dependent intracellular transport#GO:0030705;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle localization#GO:0051648;cellular localization#GO:0051641;localization#GO:0051179;microtubule-based transport#GO:0099111;organelle localization#GO:0051640;microtubule-based movement#GO:0007018;establishment of organelle localization#GO:0051656 microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;supramolecular polymer#GO:0099081;cytoskeleton#GO:0005856;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874 microtubule or microtubule-binding cytoskeletal protein#PC00157;microtubule binding motor protein#PC00156 HUMAN|HGNC=17733|UniProtKB=Q9ULM0 Q9ULM0 PLEKHH1 PTHR22903:SF4 PLEKHH PROTEIN PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY H MEMBER 1 HUMAN|HGNC=29569|UniProtKB=Q9Y234 Q9Y234 LIPT1 PTHR12561:SF3 LIPOATE-PROTEIN LIGASE LIPOYL AMIDOTRANSFERASE LIPT1, MITOCHONDRIAL acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739 protein modifying enzyme#PC00260 HUMAN|HGNC=20234|UniProtKB=Q9UI08 Q9UI08 EVL PTHR11202:SF4 SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER ENA_VASP-LIKE PROTEIN protein binding#GO:0005515;binding#GO:0005488 neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;regulation of anatomical structure size#GO:0090066;cell projection morphogenesis#GO:0048858;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;organelle organization#GO:0006996;neuron projection development#GO:0031175;cytoskeleton organization#GO:0007010;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;regulation of actin cytoskeleton organization#GO:0032956;positive regulation of cellular component biogenesis#GO:0044089;positive regulation of cellular component organization#GO:0051130;regulation of actin filament length#GO:0030832;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;neuron development#GO:0048666;regulation of biological quality#GO:0065008;axonogenesis#GO:0007409;positive regulation of organelle organization#GO:0010638;regulation of cellular component size#GO:0032535;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;regulation of organelle organization#GO:0033043;cellular component organization#GO:0016043;regulation of protein-containing complex assembly#GO:0043254;cell development#GO:0048468;regulation of cellular component biogenesis#GO:0044087;regulation of cellular component organization#GO:0051128;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell morphogenesis#GO:0000902;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;regulation of actin filament-based process#GO:0032970;neuron projection guidance#GO:0097485;actin filament organization#GO:0007015;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;positive regulation of cellular process#GO:0048522;actin polymerization or depolymerization#GO:0008154;regulation of actin filament organization#GO:0110053;axon development#GO:0061564;axon guidance#GO:0007411;regulation of actin polymerization or depolymerization#GO:0008064;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;regulation of actin filament polymerization#GO:0030833;positive regulation of protein polymerization#GO:0032273;multicellular organismal process#GO:0032501;actin filament-based process#GO:0030029;system development#GO:0048731;supramolecular fiber organization#GO:0097435;anatomical structure development#GO:0048856;regulation of supramolecular fiber organization#GO:1902903;regulation of protein polymerization#GO:0032271;regulation of cytoskeleton organization#GO:0051493;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794 anchoring junction#GO:0070161;cell junction#GO:0030054;cell periphery#GO:0071944;membrane#GO:0016020;cell-substrate junction#GO:0030055;plasma membrane#GO:0005886;focal adhesion#GO:0005925;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 Cytoskeletal regulation by Rho GTPase#P00016>Ena/VASP#P00516 HUMAN|HGNC=15482|UniProtKB=Q96PQ1 Q96PQ1 SIGLEC12 PTHR12035:SF53 SIALIC ACID BINDING IMMUNOGLOBULIN-LIKE LECTIN SIALIC ACID-BINDING IG-LIKE LECTIN 12 organic acid binding#GO:0043177;ion binding#GO:0043167;carbohydrate derivative binding#GO:0097367;anion binding#GO:0043168;binding#GO:0005488;small molecule binding#GO:0036094;carboxylic acid binding#GO:0031406 cellular process#GO:0009987;cell adhesion#GO:0007155 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 immunoglobulin superfamily cell adhesion molecule#PC00125;cell adhesion molecule#PC00069 HUMAN|HGNC=2097|UniProtKB=P23946 P23946 CMA1 PTHR24271:SF24 KALLIKREIN-RELATED CHYMASE serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;serine-type peptidase activity#GO:0008236;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 serine protease#PC00203 HUMAN|HGNC=11207|UniProtKB=Q02086 Q02086 SP2 PTHR23235:SF1 KRUEPPEL-LIKE TRANSCRIPTION FACTOR TRANSCRIPTION FACTOR SP2 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=3495|UniProtKB=P41212 P41212 ETV6 PTHR11849:SF19 ETS TRANSCRIPTION FACTOR ETV6 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110 regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 winged helix/forkhead transcription factor#PC00246;DNA-binding transcription factor#PC00218 HUMAN|HGNC=11103|UniProtKB=Q12824 Q12824 SMARCB1 PTHR10019:SF18 SNF5 SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY B MEMBER 1 transcription coactivator activity#GO:0003713;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 chromatin organization#GO:0006325;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;chromatin remodeling#GO:0006338;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355 nucleus#GO:0005634;chromatin#GO:0000785;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;chromosome#GO:0005694;SWI/SNF superfamily-type complex#GO:0070603;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ATPase complex#GO:1904949;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 DNA metabolism protein#PC00009 Wnt signaling pathway#P00057>SWI/SNF#P01435 HUMAN|HGNC=3308|UniProtKB=Q9UNI1 Q9UNI1 CELA1 PTHR24257:SF35 CHYMOTRYPSIN-LIKE ELASTASE FAMILY MEMBER CHYMOTRYPSIN-LIKE ELASTASE FAMILY MEMBER 1 serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233 cellular process#GO:0009987;primary metabolic process#GO:0044238;response to stress#GO:0006950;response to stimulus#GO:0050896;inflammatory response#GO:0006954;metabolic process#GO:0008152;proteolysis#GO:0006508;defense response#GO:0006952;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protein modifying enzyme#PC00260;protease#PC00190;serine protease#PC00203 HUMAN|HGNC=8587|UniProtKB=P22234 P22234 PAICS PTHR43599:SF11 MULTIFUNCTIONAL PROTEIN ADE2 BIFUNCTIONAL PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE_PHOSPHORIBOSYLAMINOIMIDAZOLE SUCCINOCARBOXAMIDE SYNTHETASE ligase activity, forming carbon-nitrogen bonds#GO:0016879;ligase activity#GO:0016874;catalytic activity#GO:0003824 ribose phosphate biosynthetic process#GO:0046390;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;purine nucleoside monophosphate metabolic process#GO:0009126;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;small molecule metabolic process#GO:0044281;purine ribonucleoside monophosphate metabolic process#GO:0009167;ribonucleotide metabolic process#GO:0009259;purine nucleotide biosynthetic process#GO:0006164;nucleoside monophosphate biosynthetic process#GO:0009124;purine-containing compound biosynthetic process#GO:0072522;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide biosynthetic process#GO:0009165;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;carbohydrate derivative metabolic process#GO:1901135;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;nucleoside phosphate biosynthetic process#GO:1901293;primary metabolic process#GO:0044238;IMP metabolic process#GO:0046040;nucleoside phosphate metabolic process#GO:0006753;nucleoside monophosphate metabolic process#GO:0009123;IMP biosynthetic process#GO:0006188;organophosphate biosynthetic process#GO:0090407 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 HUMAN|HGNC=18578|UniProtKB=Q9NUQ3 Q9NUQ3 TXLNG PTHR16127:SF14 TAXILIN GAMMA-TAXILIN biological regulation#GO:0065007;regulation of cell cycle#GO:0051726;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789 membrane traffic protein#PC00150 HUMAN|HGNC=33114|UniProtKB=Q6PG37 Q6PG37 ZNF790 PTHR24377:SF719 IP01015P-RELATED ZINC FINGER PROTEIN 790 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=24662|UniProtKB=Q9NQT4 Q9NQT4 EXOSC5 PTHR11953:SF1 EXOSOME COMPLEX COMPONENT EXOSOME COMPLEX COMPONENT RRP46 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 snRNA processing#GO:0016180;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;rRNA metabolic process#GO:0016072;negative regulation of cellular process#GO:0048523;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;nuclear mRNA surveillance#GO:0071028;negative regulation of macromolecule metabolic process#GO:0010605;macromolecule biosynthetic process#GO:0009059;nucleic acid catabolic process#GO:0141188;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;snRNA metabolic process#GO:0016073;RNA biosynthetic process#GO:0032774;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA 3'-end processing#GO:0031123;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule catabolic process#GO:0009057;RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;RNA metabolic process#GO:0016070;RNA catabolic process#GO:0006401;nucleic acid biosynthetic process#GO:0141187;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;snRNA 3'-end processing#GO:0034472;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629 membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;organelle lumen#GO:0043233;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 exoribonuclease#PC00099;RNA metabolism protein#PC00031 HUMAN|HGNC=25110|UniProtKB=Q9BRP7 Q9BRP7 FDXACB1 PTHR11538:SF26 PHENYLALANYL-TRNA SYNTHETASE FERREDOXIN-FOLD ANTICODON-BINDING DOMAIN-CONTAINING PROTEIN 1 catalytic activity, acting on a rRNA#GO:0140102;catalytic activity, acting on a tRNA#GO:0140101;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;N-methyltransferase activity#GO:0008170;rRNA methyltransferase activity#GO:0008649;RNA methyltransferase activity#GO:0008173;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;catalytic activity#GO:0003824;ligase activity#GO:0016874 ribonucleoprotein complex biogenesis#GO:0022613;protein biosynthetic process#GO:0160307;rRNA modification#GO:0000154;RNA metabolic process#GO:0016070;methylation#GO:0032259;RNA modification#GO:0009451;macromolecule methylation#GO:0043414;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;RNA processing#GO:0006396;gene expression#GO:0010467;rRNA base methylation#GO:0070475;cellular process#GO:0009987;tRNA aminoacylation for protein translation#GO:0006418;cellular component biogenesis#GO:0044085;rRNA methylation#GO:0031167;cellular component organization or biogenesis#GO:0071840;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;rRNA processing#GO:0006364;RNA methylation#GO:0001510;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;translation#GO:0006412;amino acid metabolic process#GO:0006520;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;macromolecule biosynthetic process#GO:0009059;tRNA aminoacylation#GO:0043039;amino acid activation#GO:0043038;macromolecule metabolic process#GO:0043170;rRNA metabolic process#GO:0016072 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 aminoacyl-tRNA synthetase#PC00047 HUMAN|HGNC=15716|UniProtKB=Q9Y5Z4 Q9Y5Z4 HEBP2 PTHR11220:SF70 HEME-BINDING PROTEIN-RELATED HEME-BINDING PROTEIN 2 tetrapyrrole binding#GO:0046906;binding#GO:0005488;heme binding#GO:0020037 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=2240|UniProtKB=Q92905 Q92905 COPS5 PTHR10410:SF6 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED COP9 SIGNALOSOME COMPLEX SUBUNIT 5 metallopeptidase activity#GO:0008237;deubiquitinase activity#GO:0101005;catalytic activity#GO:0003824;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of cell cycle#GO:0051726 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;COP9 signalosome#GO:0008180;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634 translation initiation factor#PC00224;translation factor#PC00223 PDGF signaling pathway#P00047>c-Jun#P01163 HUMAN|HGNC=8071|UniProtKB=Q9UBU9 Q9UBU9 NXF1 PTHR10662:SF27 NUCLEAR RNA EXPORT FACTOR NUCLEAR RNA EXPORT FACTOR 1 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;nitrogen compound transport#GO:0071705;macromolecule localization#GO:0033036;biosynthetic process#GO:0009058;gene expression#GO:0010467;transport#GO:0006810;RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907;metabolic process#GO:0008152;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;poly(A)+ mRNA export from nucleus#GO:0016973;mRNA transport#GO:0051028;establishment of RNA localization#GO:0051236;RNA localization#GO:0006403;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;nucleocytoplasmic transport#GO:0006913;nuclear export#GO:0051168;nuclear transport#GO:0051169;nucleic acid transport#GO:0050657;mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;localization#GO:0051179 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031 HUMAN|HGNC=25720|UniProtKB=Q96I76 Q96I76 GPATCH3 PTHR14390:SF3 G PATCH DOMAIN CONTAINING PROTEIN 3 G PATCH DOMAIN-CONTAINING PROTEIN 3 regulation of immune response#GO:0050776;regulation of defense response#GO:0031347;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;negative regulation of multicellular organismal process#GO:0051241;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;positive regulation of RNA metabolic process#GO:0051254;regulation of cell communication#GO:0010646;regulation of response to biotic stimulus#GO:0002831;regulation of response to stress#GO:0080134;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of innate immune response#GO:0045088;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of cytokine production#GO:0001817;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;negative regulation of response to stimulus#GO:0048585;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;negative regulation of biosynthetic process#GO:0009890;negative regulation of immune system process#GO:0002683;regulation of signal transduction#GO:0009966;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;negative regulation of metabolic process#GO:0009892;negative regulation of macromolecule biosynthetic process#GO:0010558;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604;regulation of response to external stimulus#GO:0032101;negative regulation of signal transduction#GO:0009968;regulation of multicellular organismal process#GO:0051239 HUMAN|HGNC=30321|UniProtKB=Q6WCQ1 Q6WCQ1 MPRIP PTHR17271:SF9 PLECKSTRIN HOMOLOGY PH DOMAIN-CONTAINING PROTEIN MYOSIN PHOSPHATASE RHO-INTERACTING PROTEIN protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;actin filament binding#GO:0051015 actin cytoskeleton#GO:0015629;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=4010|UniProtKB=P35637 P35637 FUS PTHR23238:SF5 RNA BINDING PROTEIN RNA-BINDING PROTEIN FUS RNA binding#GO:0003723;transcription regulator activity#GO:0140110;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription coregulator activity#GO:0003712 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031 HUMAN|HGNC=11253|UniProtKB=Q9BUD6 Q9BUD6 SPON2 PTHR11311:SF15 SPONDIN SPONDIN-2 cellular process#GO:0009987;cell adhesion#GO:0007155 extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical structure#GO:0110165 cell adhesion molecule#PC00069 HUMAN|HGNC=5598|UniProtKB=A0A0C4DH35 A0A0C4DH35 IGHV3-35 PTHR23266:SF372 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 3-23-RELATED antigen binding#GO:0003823;binding#GO:0005488 response to stimulus#GO:0050896;adaptive immune response#GO:0002250;immune response#GO:0006955;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449;immunoglobulin mediated immune response#GO:0016064;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immune system process#GO:0002376;immune effector process#GO:0002252 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=24999|UniProtKB=Q8IUR7 Q8IUR7 ARMC8 PTHR15651:SF7 ARMADILLO REPEAT-CONTAINING PROTEIN 8 ARMADILLO REPEAT-CONTAINING PROTEIN 8 primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511 transferase complex#GO:1990234;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;intracellular protein-containing complex#GO:0140535 HUMAN|HGNC=13518|UniProtKB=Q9Y696 Q9Y696 CLIC4 PTHR43920:SF7 CHLORIDE INTRACELLULAR CHANNEL, ISOFORM A CHLORIDE INTRACELLULAR CHANNEL PROTEIN 4 monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;chloride transmembrane transporter activity#GO:0015108;passive transmembrane transporter activity#GO:0022803;chloride channel activity#GO:0005254;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic anion transmembrane transporter activity#GO:0008509;monoatomic anion channel activity#GO:0005253;channel activity#GO:0015267 establishment of localization#GO:0051234;localization#GO:0051179;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698;monoatomic anion transport#GO:0006820;chloride transport#GO:0006821;transport#GO:0006810 membrane#GO:0016020;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 ion channel#PC00133;transporter#PC00227 HUMAN|HGNC=38601|UniProtKB=Q6ZUB0 Q6ZUB0 SPATA31D4 PTHR21859:SF50 ACROSOME-SPECIFIC PROTEIN SPERMATOGENESIS-ASSOCIATED PROTEIN 31D3-RELATED HUMAN|HGNC=6711|UniProtKB=Q06643 Q06643 LTB PTHR11471:SF29 TUMOR NECROSIS FACTOR FAMILY MEMBER LYMPHOTOXIN-BETA cytokine activity#GO:0005125;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546 regulation of extrinsic apoptotic signaling pathway#GO:2001236;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;positive regulation of apoptotic signaling pathway#GO:2001235;regulation of apoptotic signaling pathway#GO:2001233;cell communication#GO:0007154;positive regulation of cellular process#GO:0048522;regulation of canonical NF-kappaB signal transduction#GO:0043122;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;positive regulation of extrinsic apoptotic signaling pathway#GO:2001238;regulation of programmed cell death#GO:0043067;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;positive regulation of programmed cell death#GO:0043068;signaling#GO:0023052;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;cell surface receptor signaling pathway#GO:0007166;regulation of apoptotic process#GO:0042981;positive regulation of apoptotic process#GO:0043065;positive regulation of canonical NF-kappaB signal transduction#GO:0043123 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 Apoptosis signaling pathway#P00006>TNF#P00259 HUMAN|HGNC=1681|UniProtKB=P16070 P16070 CD44 PTHR10225:SF6 HYALURONAN RECEPTOR CD44 ANTIGEN ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;binding#GO:0005488;carboxylic acid binding#GO:0031406;transmembrane signaling receptor activity#GO:0004888;organic acid binding#GO:0043177;molecular transducer activity#GO:0060089;cytokine receptor activity#GO:0004896;immune receptor activity#GO:0140375;signaling receptor activity#GO:0038023 biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of ERK1 and ERK2 cascade#GO:0070372;positive regulation of response to stimulus#GO:0048584;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;response to stress#GO:0006950;defense response#GO:0006952;positive regulation of MAPK cascade#GO:0043410;regulation of MAPK cascade#GO:0043408;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;regulation of cell communication#GO:0010646;positive regulation of ERK1 and ERK2 cascade#GO:0070374;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;positive regulation of signaling#GO:0023056;inflammatory response#GO:0006954;cell adhesion#GO:0007155;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531 membrane#GO:0016020;basal part of cell#GO:0045178;basolateral plasma membrane#GO:0016323;cell periphery#GO:0071944;basal plasma membrane#GO:0009925;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane region#GO:0098590;plasma membrane#GO:0005886;signaling receptor complex#GO:0043235 transmembrane signal receptor#PC00197 Alzheimer disease-presenilin pathway#P00004>CD44#P00145;Alzheimer disease-presenilin pathway#P00004>CD44 intracellular fragment#P00121;Alzheimer disease-presenilin pathway#P00004>CD44 C-terminal fragment#P00123;Alzheimer disease-presenilin pathway#P00004>CD44 N-terminal fragment#P00174;Alzheimer disease-presenilin pathway#P00004>CD44 transmembrane fragment#P00167 HUMAN|HGNC=34346|UniProtKB=A7E2U8 A7E2U8 CFAP96 PTHR31144:SF1 UPF0602 PROTEIN C4ORF47 CILIA-AND FLAGELLA-ASSOCIATED PROTEIN 96 supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;centrosome#GO:0005813;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasmic microtubule#GO:0005881;microtubule#GO:0005874;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=15319|UniProtKB=Q8NH87 Q8NH87 OR9G1 PTHR24242:SF158 G-PROTEIN COUPLED RECEPTOR OLFACTORY RECEPTOR 9G1-RELATED G-protein coupled receptor#PC00021 HUMAN|HGNC=25618|UniProtKB=Q8IY42 Q8IY42 PGCKA1 PTHR16106:SF3 CHROMOSOME 4 OPEN READING FRAME 19 PDCD10 AND GCKIII KINASES-ASSOCIATED PROTEIN 1 HUMAN|HGNC=29292|UniProtKB=Q5VUJ6 Q5VUJ6 LRCH2 PTHR16083:SF11 LEUCINE RICH REPEAT CONTAINING PROTEIN LEUCINE-RICH REPEAT AND CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN 2 scaffold/adaptor protein#PC00226 HUMAN|HGNC=4684|UniProtKB=P33402 P33402 GUCY1A2 PTHR45655:SF7 GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2 GUANYLATE CYCLASE SOLUBLE SUBUNIT ALPHA-2 catalytic activity#GO:0003824;phosphorus-oxygen lyase activity#GO:0016849;cyclase activity#GO:0009975;lyase activity#GO:0016829;guanylate cyclase activity#GO:0004383 response to stimulus#GO:0050896;response to abiotic stimulus#GO:0009628;response to oxygen levels#GO:0070482 cytosol#GO:0005829;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 cyclase#PC00079;guanylate cyclase#PC00114 Endothelin signaling pathway#P00019>Guanylate cyclase#P00581 HUMAN|HGNC=1959|UniProtKB=P30532 P30532 CHRNA5 PTHR18945:SF76 NEUROTRANSMITTER GATED ION CHANNEL NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-5 gated channel activity#GO:0022836;postsynaptic neurotransmitter receptor activity#GO:0098960;transmembrane signaling receptor activity#GO:0004888;acetylcholine receptor activity#GO:0015464;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;neurotransmitter receptor activity#GO:0030594;signaling receptor activity#GO:0038023;monoatomic ion channel activity#GO:0005216;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated monoatomic ion channel activity#GO:0015276;channel activity#GO:0015267;molecular transducer activity#GO:0060089;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;monoatomic cation channel activity#GO:0005261 regulation of biological process#GO:0050789;signaling#GO:0023052;response to stimulus#GO:0050896;response to oxygen-containing compound#GO:1901700;regulation of signaling#GO:0023051;cellular response to chemical stimulus#GO:0070887;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;transmembrane transport#GO:0055085;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987;synaptic signaling#GO:0099536;response to chemical#GO:0042221;regulation of trans-synaptic signaling#GO:0099177;neuromuscular synaptic transmission#GO:0007274;calcium ion transport#GO:0006816;regulation of membrane potential#GO:0042391;cellular response to stimulus#GO:0051716;chemical synaptic transmission#GO:0007268;modulation of chemical synaptic transmission#GO:0050804;metal ion transport#GO:0030001;membrane depolarization#GO:0051899;regulation of cell communication#GO:0010646;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;trans-synaptic signaling#GO:0099537;response to nitrogen compound#GO:1901698;localization#GO:0051179;cell communication#GO:0007154;monoatomic cation transport#GO:0006812;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;monoatomic ion transmembrane transport#GO:0034220;synaptic transmission, cholinergic#GO:0007271;acetylcholine receptor signaling pathway#GO:0095500;cellular response to nitrogen compound#GO:1901699;transport#GO:0006810;establishment of localization#GO:0051234 plasma membrane protein complex#GO:0098797;postsynapse#GO:0098794;membrane protein complex#GO:0098796;cellular anatomical structure#GO:0110165;synapse#GO:0045202;postsynaptic membrane#GO:0045211;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;plasma membrane region#GO:0098590;signaling receptor complex#GO:0043235;synaptic membrane#GO:0097060;transporter complex#GO:1990351;cell junction#GO:0030054 ligand-gated ion channel#PC00141 Nicotine pharmacodynamics pathway#P06587>CHRNA5#P06593;Nicotinic acetylcholine receptor signaling pathway#P00044>alpha#P01088;Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086 HUMAN|HGNC=14034|UniProtKB=Q9BZE1 Q9BZE1 MRPL37 PTHR15889:SF2 MITOCHONDRIAL RIBOSOMAL PROTEIN L37 LARGE RIBOSOMAL SUBUNIT PROTEIN ML37 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 ribosomal protein#PC00202 HUMAN|HGNC=9702|UniProtKB=Q96QR8 Q96QR8 PURB PTHR12611:SF4 PUR-TRANSCRIPTIONAL ACTIVATOR TRANSCRIPTIONAL REGULATOR PROTEIN PUR-BETA DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HUMAN|HGNC=32686|UniProtKB=A6NK02 A6NK02 TRIM75 PTHR24103:SF312 E3 UBIQUITIN-PROTEIN LIGASE TRIM TRIPARTITE MOTIF-CONTAINING PROTEIN 75 transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842 immune system process#GO:0002376;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;regulation of macromolecule metabolic process#GO:0060255;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;response to external stimulus#GO:0009605;defense response#GO:0006952;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;innate immune response#GO:0045087;biological regulation#GO:0065007;response to other organism#GO:0051707;defense response to other organism#GO:0098542;immune response#GO:0006955;defense response to symbiont#GO:0140546;response to biotic stimulus#GO:0009607;regulation of metabolic process#GO:0019222;response to stress#GO:0006950;regulation of macromolecule biosynthetic process#GO:0010556 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=28742|UniProtKB=Q6ZNG0 Q6ZNG0 ZNF620 PTHR24381:SF114 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 620 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=30419|UniProtKB=Q7Z5J1 Q7Z5J1 HSD11B1L PTHR44279:SF3 HYDROXYSTEROID (11-BETA) DEHYDROGENASE 1-LIKE B-RELATED HYDROXYSTEROID 11-BETA-DEHYDROGENASE 1-LIKE PROTEIN oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229 dehydrogenase#PC00092 HUMAN|HGNC=8620|UniProtKB=P26367 P26367 PAX6 PTHR45636:SF48 PAIRED BOX PROTEIN PAX-6-RELATED-RELATED PAIRED BOX PROTEIN PAX-6 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690 anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;camera-type eye development#GO:0043010;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;visual system development#GO:0150063;pancreas development#GO:0031016;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;sensory organ development#GO:0007423;developmental process#GO:0032502;regulation of nucleobase-containing compound metabolic process#GO:0019219;epithelium development#GO:0060429;brain development#GO:0007420;multicellular organismal process#GO:0032501;epithelial cell differentiation#GO:0030855;tissue development#GO:0009888;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;eye development#GO:0001654;animal gross anatomical part developmental process#GO:0160108;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;central nervous system development#GO:0007417;forebrain development#GO:0030900;regulation of biological process#GO:0050789;multicellular organism development#GO:0007275;animal organ development#GO:0048513;retina development in camera-type eye#GO:0060041;head development#GO:0060322;nervous system development#GO:0007399;sensory system development#GO:0048880;cellular process#GO:0009987 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116;DNA-binding transcription factor#PC00218 HUMAN|HGNC=200|UniProtKB=Q9UKJ8 Q9UKJ8 ADAM21 PTHR11905:SF116 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 21 catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;metalloendopeptidase activity#GO:0004222;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;proteolysis#GO:0006508;metabolic process#GO:0008152;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 metalloprotease#PC00153;protease#PC00190 HUMAN|HGNC=40034|UniProtKB=A6NJW4 A6NJW4 LRRC3C PTHR24373:SF410 SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN LEUCINE-RICH REPEAT-CONTAINING PROTEIN 3C signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=28204|UniProtKB=Q9BSD7 Q9BSD7 NTPCR PTHR43146:SF1 CANCER-RELATED NUCLEOSIDE-TRIPHOSPHATASE CANCER-RELATED NUCLEOSIDE-TRIPHOSPHATASE hydrolase#PC00121;phosphatase#PC00181 HUMAN|HGNC=30653|UniProtKB=Q7Z7C7 Q7Z7C7 STRA8 PTHR35254:SF1 STIMULATED BY RETINOIC ACID GENE 8 PROTEIN HOMOLOG STIMULATED BY RETINOIC ACID GENE 8 PROTEIN HOMOLOG HUMAN|HGNC=29489|UniProtKB=Q9NQR1 Q9NQR1 KMT5A PTHR46167:SF1 N-LYSINE METHYLTRANSFERASE KMT5A N-LYSINE METHYLTRANSFERASE KMT5A catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring one-carbon groups#GO:0016741;protein methyltransferase activity#GO:0008276;lysine N-methyltransferase activity#GO:0016278;histone modifying activity#GO:0140993;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;histone methyltransferase activity#GO:0042054;protein-lysine N-methyltransferase activity#GO:0016279;N-methyltransferase activity#GO:0008170 cellular component assembly#GO:0022607;heterochromatin organization#GO:0070828;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;organelle organization#GO:0006996;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;negative regulation of gene expression, epigenetic#GO:0045814;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;chromosome condensation#GO:0030261;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;epigenetic regulation of gene expression#GO:0040029;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;chromosome organization#GO:0051276;negative regulation of cellular process#GO:0048523;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;heterochromatin formation#GO:0031507;regulation of DNA-templated transcription#GO:0006355;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252 chromosome#GO:0005694;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 protein modifying enzyme#PC00260 HUMAN|HGNC=11115|UniProtKB=Q9BY66 Q9BY66 KDM5D PTHR10694:SF84 LYSINE-SPECIFIC DEMETHYLASE LYSINE-SPECIFIC DEMETHYLASE 5D oxidoreductase activity#GO:0016491;catalytic activity, acting on a protein#GO:0140096;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;demethylase activity#GO:0032451;protein demethylase activity#GO:0140457;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;histone demethylase activity#GO:0032452;catalytic activity#GO:0003824;histone modifying activity#GO:0140993;dioxygenase activity#GO:0051213 cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of gene expression#GO:0010468;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;chromatin remodeling#GO:0006338;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694 histone modifying enzyme#PC00261 HUMAN|HGNC=19682|UniProtKB=Q8TF76 Q8TF76 HASPIN PTHR24419:SF18 INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE SERINE_THREONINE-PROTEIN KINASE HASPIN histone modifying activity#GO:0140993;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;histone kinase activity#GO:0035173;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740 cell cycle#GO:0007049;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;mitotic cell cycle#GO:0000278;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=29912|UniProtKB=Q13137 Q13137 CALCOCO2 PTHR31915:SF4 SKICH DOMAIN-CONTAINING PROTEIN CALCIUM-BINDING AND COILED-COIL DOMAIN-CONTAINING PROTEIN 2 metabolic process#GO:0008152;regulation of macroautophagy#GO:0016241;autophagy#GO:0006914;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of autophagy#GO:0010508;regulation of protein-containing complex disassembly#GO:0043244;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;defense response to other organism#GO:0098542;positive regulation of cellular component organization#GO:0051130;process utilizing autophagic mechanism#GO:0061919;positive regulation of metabolic process#GO:0009893;positive regulation of organelle organization#GO:0010638;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;regulation of autophagy#GO:0010506;biological process involved in interspecies interaction between organisms#GO:0044419;positive regulation of macroautophagy#GO:0016239;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;regulation of autophagosome maturation#GO:1901096;response to external stimulus#GO:0009605;defense response#GO:0006952;regulation of catabolic process#GO:0009894;positive regulation of catabolic process#GO:0009896;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;response to other organism#GO:0051707;macroautophagy#GO:0016236;response to external biotic stimulus#GO:0043207;catabolic process#GO:0009056;regulation of cellular process#GO:0050794 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;autophagosome#GO:0005776;intracellular organelle lumen#GO:0070013;PML body#GO:0016605;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;organelle lumen#GO:0043233;membraneless organelle#GO:0043228;cytoplasm#GO:0005737;nuclear body#GO:0016604;vacuole#GO:0005773;intracellular membraneless organelle#GO:0043232;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974 HUMAN|HGNC=16747|UniProtKB=Q86UQ0 Q86UQ0 ZNF589 PTHR23232:SF170 KRAB DOMAIN C2H2 ZINC FINGER ZINC FINGER PROTEIN 589 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=29315|UniProtKB=Q9HCJ6 Q9HCJ6 VAT1L PTHR44054:SF2 SYNAPTIC VESICLE MEMBRANE PROTEIN VAT-1 HOMOLOG-LIKE NADPH-DEPENDENT QUINONE OXIDOREDUCTASE VAT1L-RELATED Huntington disease#P00029>PIG3#G01535 HUMAN|HGNC=28929|UniProtKB=Q7RTS7 Q7RTS7 KRT74 PTHR45616:SF5 GATA-TYPE DOMAIN-CONTAINING PROTEIN KERATIN, TYPE II CYTOSKELETAL 74 structural molecule activity#GO:0005198 cellular component organization#GO:0016043;cell differentiation#GO:0030154;intermediate filament cytoskeleton organization#GO:0045104;intermediate filament organization#GO:0045109;animal gross anatomical part developmental process#GO:0160108;keratinocyte differentiation#GO:0030216;intermediate filament-based process#GO:0045103;supramolecular fiber organization#GO:0097435;anatomical structure development#GO:0048856;cellular process#GO:0009987;organelle organization#GO:0006996;skin development#GO:0043588;cytoskeleton organization#GO:0007010;tissue development#GO:0009888;epidermal cell differentiation#GO:0009913;multicellular organismal process#GO:0032501;epithelial cell differentiation#GO:0030855;epithelium development#GO:0060429;developmental process#GO:0032502;epidermis development#GO:0008544;animal organ development#GO:0048513;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;intermediate filament#GO:0005882;supramolecular fiber#GO:0099512;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;organelle#GO:0043226;supramolecular complex#GO:0099080 HUMAN|HGNC=11350|UniProtKB=P78524 P78524 DENND2B PTHR15288:SF5 DENN DOMAIN-CONTAINING PROTEIN 2 DENN DOMAIN-CONTAINING PROTEIN 2B guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234 positive regulation of signaling#GO:0023056;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;positive regulation of ERK1 and ERK2 cascade#GO:0070374;regulation of cell communication#GO:0010646;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789;positive regulation of MAPK cascade#GO:0043410;regulation of MAPK cascade#GO:0043408;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;positive regulation of response to stimulus#GO:0048584;regulation of ERK1 and ERK2 cascade#GO:0070372;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522 recycling endosome#GO:0055037;membrane#GO:0016020;cell periphery#GO:0071944;endomembrane system#GO:0012505;cytoplasm#GO:0005737;plasma membrane#GO:0005886;endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=18807|UniProtKB=O94983 O94983 CAMTA2 PTHR23335:SF9 CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR CAMTA CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR 2 DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;transcription coregulator activity#GO:0003712;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription regulator activity#GO:0140110 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HUMAN|HGNC=7882|UniProtKB=Q04721 Q04721 NOTCH2 PTHR45836:SF15 SLIT HOMOLOG NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 2 system development#GO:0048731;cell communication#GO:0007154;anatomical structure development#GO:0048856;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;Notch signaling pathway#GO:0007219;cellular developmental process#GO:0048869;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;multicellular organismal process#GO:0032501;axon guidance#GO:0007411;axon development#GO:0061564;neuron development#GO:0048666;axonogenesis#GO:0007409;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;signaling#GO:0023052;cell development#GO:0048468;cell differentiation#GO:0030154;cell projection organization#GO:0030030;response to stimulus#GO:0050896;cell morphogenesis#GO:0000902;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;cell projection morphogenesis#GO:0048858;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell surface receptor signaling pathway#GO:0007166;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;signal transduction#GO:0007165;cellular process#GO:0009987;neuron projection development#GO:0031175 plasma membrane#GO:0005886;cell surface#GO:0009986;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;signaling receptor complex#GO:0043235;membrane#GO:0016020 Alzheimer disease-presenilin pathway#P00004>NICD#P00122;Alzheimer disease-presenilin pathway#P00004>Notch C-terminal fragment#P00120;Notch signaling pathway#P00045>Next#P01103;Alzheimer disease-presenilin pathway#P00004>Notch extracellular fragment#P00179;Alzheimer disease-presenilin pathway#P00004>Notch transmembrane fragment#P00135;Alzheimer disease-presenilin pathway#P00004>Notch#P00176;Notch signaling pathway#P00045>Ntm#P01114;Alzheimer disease-presenilin pathway#P00004>Notch fragment#P00154;Alzheimer disease-presenilin pathway#P00004>Notch N-terminal fragment#P00171;Notch signaling pathway#P00045>NIcs#P01120;Notch signaling pathway#P00045>NIct#P01119;Notch signaling pathway#P00045>Notch#P01099;Angiogenesis#P00005>Notch#P00255 HUMAN|HGNC=17034|UniProtKB=O75896 O75896 TUSC2 PTHR15453:SF8 TUMOR SUPPRESSOR CANDIDATE 2 TUMOR SUPPRESSOR CANDIDATE 2 inflammatory response#GO:0006954;response to stress#GO:0006950;regulation of biological quality#GO:0065008;defense response#GO:0006952;biological regulation#GO:0065007;regulation of membrane potential#GO:0042391;response to stimulus#GO:0050896 mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=25942|UniProtKB=Q8IY21 Q8IY21 DDX60 PTHR44533:SF3 DEAD/H RNA HELICASE, PUTATIVE-RELATED ATP-DEPENDENT RNA HELICASE DDX60-RELATED RNA binding#GO:0003723;single-stranded RNA binding#GO:0003727;nucleic acid binding#GO:0003676;binding#GO:0005488;double-stranded RNA binding#GO:0003725 response to virus#GO:0009615;response to external stimulus#GO:0009605;defense response#GO:0006952;defense response to virus#GO:0051607;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;response to stimulus#GO:0050896;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to other organism#GO:0051707 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 RNA helicase#PC00032 HUMAN|HGNC=21918|UniProtKB=Q6P9H5 Q6P9H5 GIMAP6 PTHR10903:SF144 GTPASE, IMAP FAMILY MEMBER-RELATED GTPASE IMAP FAMILY MEMBER 6 ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 small GTPase#PC00208 HUMAN|HGNC=11068|UniProtKB=P32418 P32418 SLC8A1 PTHR11878:SF6 SODIUM/CALCIUM EXCHANGER SODIUM_CALCIUM EXCHANGER 1 calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;monoatomic ion transmembrane transporter activity#GO:0015075;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;antiporter activity#GO:0015297 export from cell#GO:0140352;regulation of biological process#GO:0050789;sodium ion transport#GO:0006814;intracellular monoatomic ion homeostasis#GO:0006873;calcium ion transmembrane transport#GO:0070588;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;transmembrane transport#GO:0055085;inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;monoatomic cation transmembrane transport#GO:0098655;regulation of multicellular organismal process#GO:0051239;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801;intracellular calcium ion homeostasis#GO:0006874;calcium ion transport#GO:0006816;chemical homeostasis#GO:0048878;homeostatic process#GO:0042592;metal ion transport#GO:0030001;regulation of heart contraction#GO:0008016;monoatomic cation transport#GO:0006812;localization#GO:0051179;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;establishment of localization#GO:0051234;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;transport#GO:0006810;regulation of system process#GO:0044057 membrane#GO:0016020;postsynapse#GO:0098794;cell periphery#GO:0071944;neuron projection#GO:0043005;synapse#GO:0045202;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;plasma membrane#GO:0005886;postsynaptic membrane#GO:0045211;synaptic membrane#GO:0097060;axon#GO:0030424;cell junction#GO:0030054;sarcolemma#GO:0042383 secondary carrier transporter#PC00258 HUMAN|HGNC=34391|UniProtKB=Q4AC99 Q4AC99 ACCSL PTHR43795:SF1 BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED INACTIVE 1-AMINOCYCLOPROPANE-1-CARBOXYLATE SYNTHASE-LIKE PROTEIN 2-RELATED catalytic activity#GO:0003824;lyase activity#GO:0016829;carbon-sulfur lyase activity#GO:0016846 transaminase#PC00216;transferase#PC00220;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=29459|UniProtKB=Q5T7P2 Q5T7P2 LCE1A PTHR48615:SF6 LATE CORNIFIED ENVELOPE PROTEIN 1C LATE CORNIFIED ENVELOPE PROTEIN 1A-RELATED HUMAN|HGNC=26708|UniProtKB=Q6ZTR5 Q6ZTR5 CFAP47 PTHR45912:SF4 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 47 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 47 cilium organization#GO:0044782;cilium-dependent cell motility#GO:0060285;sperm flagellum assembly#GO:0120316;cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;spermatid differentiation#GO:0048515;cell development#GO:0048468;cellular process involved in reproduction in multicellular organism#GO:0022412;cell differentiation#GO:0030154;cell projection organization#GO:0030030;gamete generation#GO:0007276;sperm motility#GO:0097722;cellular component organization#GO:0016043;cilium assembly#GO:0060271;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;motile cilium assembly#GO:0044458;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;cell projection assembly#GO:0030031;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cilium movement involved in cell motility#GO:0060294;axoneme assembly#GO:0035082;multicellular organismal reproductive process#GO:0048609;microtubule cytoskeleton organization#GO:0000226;anatomical structure development#GO:0048856;sexual reproduction#GO:0019953;spermatid development#GO:0007286;microtubule bundle formation#GO:0001578;organelle assembly#GO:0070925;reproductive process#GO:0022414;cell motility#GO:0048870;microtubule-based movement#GO:0007018;germ cell development#GO:0007281;developmental process involved in reproduction#GO:0003006;sperm axoneme assembly#GO:0007288;cellular developmental process#GO:0048869;spermatogenesis#GO:0007283;developmental process#GO:0032502;flagellated sperm motility#GO:0030317;plasma membrane bounded cell projection assembly#GO:0120031;plasma membrane bounded cell projection organization#GO:0120036;male gamete generation#GO:0048232 cilium#GO:0005929;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995 structural protein#PC00211 HUMAN|HGNC=1564|UniProtKB=Q16773 Q16773 KYAT1 PTHR43807:SF14 FI04487P KYNURENINE--OXOGLUTARATE TRANSAMINASE 1 catalytic activity#GO:0003824;transferase activity#GO:0016740;transaminase activity#GO:0008483 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739 transferase#PC00220;transaminase#PC00216;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=15956|UniProtKB=Q96QE2 Q96QE2 SLC2A13 PTHR48020:SF55 PROTON MYO-INOSITOL COTRANSPORTER PROTON MYO-INOSITOL COTRANSPORTER monoatomic cation transmembrane transporter activity#GO:0008324;solute:proton symporter activity#GO:0015295;symporter activity#GO:0015293;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294;active transmembrane transporter activity#GO:0022804;proton transmembrane transporter activity#GO:0015078;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291 cellular process#GO:0009987;transport#GO:0006810;organic hydroxy compound transport#GO:0015850;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179 plasma membrane#GO:0005886;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;apical part of cell#GO:0045177;cell periphery#GO:0071944;apical plasma membrane#GO:0016324;membrane#GO:0016020 transporter#PC00227 HUMAN|HGNC=49233|UniProtKB=A8MZH6 A8MZH6 OOSP1 PTHR14380:SF3 PLACENTA-SPECIFIC PROTEIN 1 OOCYTE-SECRETED PROTEIN 1 HOMOLOG-RELATED HUMAN|HGNC=14665|UniProtKB=A6NKG5 A6NKG5 RTL1 PTHR15503:SF39 LDOC1 RELATED RETROTRANSPOSON-LIKE PROTEIN 1 skeletal muscle tissue development#GO:0007519;muscle structure development#GO:0061061;tissue development#GO:0009888;muscle organ development#GO:0007517;animal gross anatomical part developmental process#GO:0160108;skeletal muscle organ development#GO:0060538;developmental process#GO:0032502;striated muscle tissue development#GO:0014706;anatomical structure development#GO:0048856;animal organ development#GO:0048513;muscle tissue development#GO:0060537;placenta development#GO:0001890 viral or transposable element protein#PC00237 HUMAN|HGNC=2519|UniProtKB=P17812 P17812 CTPS1 PTHR11550:SF8 CTP SYNTHASE CTP SYNTHASE 1 ligase activity, forming carbon-nitrogen bonds#GO:0016879;identical protein binding#GO:0042802;protein binding#GO:0005515;ligase activity#GO:0016874;binding#GO:0005488;catalytic activity#GO:0003824 nucleoside phosphate metabolic process#GO:0006753;nucleoside triphosphate metabolic process#GO:0009141;small molecule metabolic process#GO:0044281;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;organophosphate biosynthetic process#GO:0090407;nucleotide metabolic process#GO:0009117;ribonucleotide metabolic process#GO:0009259;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;pyrimidine-containing compound metabolic process#GO:0072527;ribose phosphate metabolic process#GO:0019693;carbohydrate derivative metabolic process#GO:1901135;ribose phosphate biosynthetic process#GO:0046390;nucleoside triphosphate biosynthetic process#GO:0009142;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;nucleobase metabolic process#GO:0009112;nucleobase-containing small molecule metabolic process#GO:0055086;ribonucleoside triphosphate biosynthetic process#GO:0009201;pyrimidine nucleobase metabolic process#GO:0006206;carbohydrate derivative biosynthetic process#GO:1901137;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 supramolecular complex#GO:0099080;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;supramolecular fiber#GO:0099512;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;ligase#PC00142 De novo pyrimidine ribonucleotides biosythesis#P02740>CTP synthase#P02931 HUMAN|HGNC=56306|UniProtKB=P0DX02 P0DX02 GOLGA6L26 PTHR23143:SF31 TRICHOHYALIN-RELATED GOLGIN SUBFAMILY A MEMBER 6-LIKE PROTEIN 1-RELATED actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=17304|UniProtKB=O75529 O75529 TAF5L PTHR19879:SF6 TRANSCRIPTION INITIATION FACTOR TFIID TAF5-LIKE RNA POLYMERASE II P300_CBP-ASSOCIATED FACTOR-ASSOCIATED FACTOR 65 KDA SUBUNIT 5L structural molecule activity#GO:0005198;protein complex scaffold activity#GO:0140378 DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;DNA-templated transcription initiation#GO:0006352;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of RNA metabolic process#GO:0051252;RNA metabolic process#GO:0016070;regulation of DNA-templated transcription#GO:0006355;nucleic acid biosynthetic process#GO:0141187;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;regulation of nucleobase-containing compound metabolic process#GO:0019219;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;transcription initiation at RNA polymerase II promoter#GO:0006367;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;transcription by RNA polymerase II#GO:0006366;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;transcription regulator complex#GO:0005667;membraneless organelle#GO:0043228;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;RNA polymerase II transcription regulator complex#GO:0090575;membrane-enclosed lumen#GO:0031974;peptidase complex#GO:1905368;catalytic complex#GO:1902494;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;RNA polymerase II, holoenzyme#GO:0016591;SAGA-type complex#GO:0070461;nuclear DNA-directed RNA polymerase complex#GO:0055029;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;histone acetyltransferase complex#GO:0000123;nuclear protein-containing complex#GO:0140513;chromatin#GO:0000785;SAGA complex#GO:0000124;transcription factor TFIID complex#GO:0005669;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;protein acetyltransferase complex#GO:0031248;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;acetyltransferase complex#GO:1902493;organelle lumen#GO:0043233;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226 HUMAN|HGNC=6416|UniProtKB=P02533 P02533 KRT14 PTHR23239:SF368 INTERMEDIATE FILAMENT KERATIN, TYPE I CYTOSKELETAL 14 structural molecule activity#GO:0005198 anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;cell differentiation#GO:0030154;intermediate filament cytoskeleton organization#GO:0045104;intermediate filament organization#GO:0045109;intermediate filament-based process#GO:0045103;animal gross anatomical part developmental process#GO:0160108;keratinocyte differentiation#GO:0030216;supramolecular fiber organization#GO:0097435;tissue morphogenesis#GO:0048729;anatomical structure development#GO:0048856;cellular process#GO:0009987;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;skin development#GO:0043588;epithelium development#GO:0060429;tissue development#GO:0009888;epithelial cell differentiation#GO:0030855;epidermal cell differentiation#GO:0009913;developmental process#GO:0032502;epidermis development#GO:0008544;morphogenesis of an epithelium#GO:0002009;cellular component organization or biogenesis#GO:0071840;animal organ development#GO:0048513;cellular developmental process#GO:0048869 organelle#GO:0043226;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;intermediate filament#GO:0005882;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622 intermediate filament#PC00129 HUMAN|HGNC=19760|UniProtKB=Q96T51 Q96T51 RUFY1 PTHR45956:SF4 RUN AND FYVE DOMAIN-CONTAINING PROTEIN 2-LIKE PROTEIN RUN AND FYVE DOMAIN-CONTAINING PROTEIN 1 regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;macromolecule localization#GO:0033036;establishment of protein localization#GO:0045184;regulation of biological process#GO:0050789;localization#GO:0051179;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;regulation of transport#GO:0051049;regulation of localization#GO:0032879;protein transport#GO:0015031;regulation of endocytosis#GO:0030100;transport#GO:0006810 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229 HUMAN|HGNC=8472|UniProtKB=Q8NGG8 Q8NGG8 OR8B3 PTHR48018:SF61 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 8B2-RELATED transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;sensory perception#GO:0007600;nervous system process#GO:0050877;response to stimulus#GO:0050896;sensory perception of smell#GO:0007608;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;signal transduction#GO:0007165;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=18271|UniProtKB=Q8N8S7 Q8N8S7 ENAH PTHR11202:SF1 SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER PROTEIN ENABLED HOMOLOG protein binding#GO:0005515;binding#GO:0005488 cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;cytoskeleton organization#GO:0007010;cellular process#GO:0009987;organelle organization#GO:0006996;neuron projection development#GO:0031175;cell projection morphogenesis#GO:0048858;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;cell development#GO:0048468;cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;cell differentiation#GO:0030154;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;axonogenesis#GO:0007409;neuron development#GO:0048666;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;plasma membrane bounded cell projection organization#GO:0120036;multicellular organismal process#GO:0032501;actin polymerization or depolymerization#GO:0008154;axon guidance#GO:0007411;axon development#GO:0061564;neurogenesis#GO:0022008;neuron projection guidance#GO:0097485;actin filament organization#GO:0007015;cellular developmental process#GO:0048869;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;cell motility#GO:0048870;actin cytoskeleton organization#GO:0030036;supramolecular fiber organization#GO:0097435;system development#GO:0048731;anatomical structure development#GO:0048856;actin filament-based process#GO:0030029 cell junction#GO:0030054;anchoring junction#GO:0070161;membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;focal adhesion#GO:0005925;plasma membrane#GO:0005886;cell-substrate junction#GO:0030055 scaffold/adaptor protein#PC00226 Axon guidance mediated by Slit/Robo#P00008>Mena#P00345;Cytoskeletal regulation by Rho GTPase#P00016>Ena/VASP#P00516;Axon guidance mediated by netrin#P00009>Ena#P00361 HUMAN|HGNC=29945|UniProtKB=Q6N022 Q6N022 TENM4 PTHR11219:SF9 TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE TENEURIN-4 signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515 plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cell projection morphogenesis#GO:0048858;cell-cell adhesion#GO:0098609;neuron projection development#GO:0031175;cellular process#GO:0009987;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;animal gross anatomical part developmental process#GO:0160108;cell adhesion#GO:0007155;generation of neurons#GO:0048699;neuron development#GO:0048666;axonogenesis#GO:0007409;synaptic membrane adhesion#GO:0099560;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell development#GO:0048468;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;neuron projection guidance#GO:0097485;axon guidance#GO:0007411;axon development#GO:0061564;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;synapse organization#GO:0050808;anatomical structure development#GO:0048856;system development#GO:0048731;cell junction organization#GO:0034330 cell junction#GO:0030054;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;glutamatergic synapse#GO:0098978;cellular anatomical structure#GO:0110165;synapse#GO:0045202;cell projection#GO:0042995;plasma membrane#GO:0005886;plasma membrane bounded cell projection#GO:0120025 HUMAN|HGNC=11035|UniProtKB=Q96Q91 Q96Q91 SLC4A9 PTHR11453:SF52 ANION EXCHANGE PROTEIN ANION EXCHANGE PROTEIN 4 secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;bicarbonate transmembrane transporter activity#GO:0015106;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;solute:monoatomic cation symporter activity#GO:0015294;monoatomic ion transmembrane transporter activity#GO:0015075;symporter activity#GO:0015293;monoatomic cation transmembrane transporter activity#GO:0008324;solute:sodium symporter activity#GO:0015370 transport#GO:0006810;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;establishment of localization#GO:0051234;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;biological regulation#GO:0065007;regulation of pH#GO:0006885;regulation of intracellular pH#GO:0051453;localization#GO:0051179;transmembrane transport#GO:0055085;regulation of biological quality#GO:0065008;intracellular monoatomic ion homeostasis#GO:0006873;homeostatic process#GO:0042592 cell periphery#GO:0071944;basal plasma membrane#GO:0009925;membrane#GO:0016020;basolateral plasma membrane#GO:0016323;basal part of cell#GO:0045178;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590 secondary carrier transporter#PC00258 HUMAN|HGNC=16410|UniProtKB=Q96LL9 Q96LL9 DNAJC30 PTHR44873:SF1 DNAJ HOMOLOG SUBFAMILY C MEMBER 30, MITOCHONDRIAL DNAJ HOMOLOG SUBFAMILY C MEMBER 30, MITOCHONDRIAL chaperone#PC00072 HUMAN|HGNC=283|UniProtKB=P18825 P18825 ADRA2C PTHR24248:SF25 ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR ALPHA-2C ADRENERGIC RECEPTOR transmembrane signaling receptor activity#GO:0004888;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;cation binding#GO:0043169;molecular transducer activity#GO:0060089;G protein-coupled amine receptor activity#GO:0008227;hormone binding#GO:0042562;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930 adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway#GO:0007193;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cell communication#GO:0007154;adrenergic receptor signaling pathway#GO:0071875;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;Alpha adrenergic receptor signaling pathway#P00002>Alpha1A/1B/1C#P00078 HUMAN|HGNC=24825|UniProtKB=Q9BVC4 Q9BVC4 MLST8 PTHR19842:SF0 G BETA-LIKE PROTEIN GBL TARGET OF RAPAMYCIN COMPLEX SUBUNIT LST8 regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;regulation of cytoskeleton organization#GO:0051493;signaling#GO:0023052;cellular response to stimulus#GO:0051716;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;TOR signaling#GO:0031929;regulation of actin cytoskeleton organization#GO:0032956;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of actin filament-based process#GO:0032970 protein-containing complex#GO:0032991;TOR complex#GO:0038201;intracellular protein-containing complex#GO:0140535 HUMAN|HGNC=34497|UniProtKB=A6NGS2 A6NGS2 ERICH4 PTHR36879:SF1 GLUTAMATE-RICH PROTEIN 4 GLUTAMATE-RICH PROTEIN 4 HUMAN|HGNC=15230|UniProtKB=Q8NGI2 Q8NGI2 OR52N4 PTHR26450:SF194 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 52N4 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=5297|UniProtKB=P46098 P46098 HTR3A PTHR18945:SF52 NEUROTRANSMITTER GATED ION CHANNEL 5-HYDROXYTRYPTAMINE RECEPTOR 3A transporter activity#GO:0005215;neurotransmitter receptor activity#GO:0030594;signaling receptor activity#GO:0038023;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;gated channel activity#GO:0022836;transmembrane signaling receptor activity#GO:0004888;monoatomic cation transmembrane transporter activity#GO:0008324;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;monoatomic cation channel activity#GO:0005261;ligand-gated monoatomic ion channel activity#GO:0015276;channel activity#GO:0015267;molecular transducer activity#GO:0060089 cell-cell signaling#GO:0007267;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;synaptic transmission, cholinergic#GO:0007271;cellular process#GO:0009987;synaptic signaling#GO:0099536;calcium ion transport#GO:0006816;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;transport#GO:0006810;metal ion transport#GO:0030001;signaling#GO:0023052;anterograde trans-synaptic signaling#GO:0098916;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;cell communication#GO:0007154;transmembrane transport#GO:0055085;trans-synaptic signaling#GO:0099537 signaling receptor complex#GO:0043235;cation channel complex#GO:0034703;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991 ligand-gated ion channel#PC00141 Gonadotropin-releasing hormone receptor pathway#P06664>5-HT3AR#P06833;5HT3 type receptor mediated signaling pathway#P04375>5HT3 Rec#P04422 HUMAN|HGNC=9240|UniProtKB=P02775 P02775 PPBP PTHR12015:SF216 SMALL INDUCIBLE CYTOKINE A PLATELET BASIC PROTEIN chemokine activity#GO:0008009;G protein-coupled receptor binding#GO:0001664;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;binding#GO:0005488;signaling receptor binding#GO:0005102;cytokine receptor binding#GO:0005126;cytokine activity#GO:0005125;molecular function activator activity#GO:0140677;chemokine receptor binding#GO:0042379;protein binding#GO:0005515 cell motility#GO:0048870;locomotion#GO:0040011;response to external biotic stimulus#GO:0043207;cellular response to biotic stimulus#GO:0071216;cellular response to stimulus#GO:0051716;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;cell chemotaxis#GO:0060326;response to bacterium#GO:0009617;chemotaxis#GO:0006935;inflammatory response#GO:0006954;cell migration#GO:0016477;response to other organism#GO:0051707;immune response#GO:0006955;cellular response to molecule of bacterial origin#GO:0071219;defense response#GO:0006952;leukocyte chemotaxis#GO:0030595;myeloid leukocyte migration#GO:0097529;response to external stimulus#GO:0009605;leukocyte migration#GO:0050900;response to stimulus#GO:0050896;granulocyte chemotaxis#GO:0071621;biological process involved in interspecies interaction between organisms#GO:0044419;response to molecule of bacterial origin#GO:0002237;cellular response to chemical stimulus#GO:0070887;immune system process#GO:0002376;response to oxygen-containing compound#GO:1901700;granulocyte migration#GO:0097530;response to lipid#GO:0033993;defense response to other organism#GO:0098542;cellular response to lipid#GO:0071396;taxis#GO:0042330;response to chemical#GO:0042221;neutrophil migration#GO:1990266;response to stress#GO:0006950;cellular response to lipopolysaccharide#GO:0071222;response to biotic stimulus#GO:0009607;cellular process#GO:0009987;defense response to symbiont#GO:0140546;cellular response to oxygen-containing compound#GO:1901701;response to lipopolysaccharide#GO:0032496;antimicrobial humoral response#GO:0019730;humoral immune response#GO:0006959;neutrophil chemotaxis#GO:0030593 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 cytokine#PC00083 HUMAN|HGNC=6120|UniProtKB=Q13568 Q13568 IRF5 PTHR11949:SF10 INTERFERON REGULATORY FACTOR INTERFERON REGULATORY FACTOR 5 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cell surface receptor signaling pathway#GO:0007166;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;response to cytokine#GO:0034097;response to chemical#GO:0042221;regulation of nucleobase-containing compound metabolic process#GO:0019219;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA metabolic process#GO:0051252;response to peptide#GO:1901652;cell communication#GO:0007154;regulation of DNA-templated transcription#GO:0006355;cytokine-mediated signaling pathway#GO:0019221;signaling#GO:0023052;regulation of macromolecule metabolic process#GO:0060255;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;cellular response to stimulus#GO:0051716 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 winged helix/forkhead transcription factor#PC00246;DNA-binding transcription factor#PC00218 HUMAN|HGNC=42955|UniProtKB=A6NDI0 A6NDI0 TRIM49B PTHR24103:SF615 E3 UBIQUITIN-PROTEIN LIGASE TRIM TRIPARTITE MOTIF-CONTAINING PROTEIN 49B-RELATED ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824 immune system process#GO:0002376;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of gene expression#GO:0010468;defense response#GO:0006952;response to external stimulus#GO:0009605;regulation of biosynthetic process#GO:0009889;innate immune response#GO:0045087;response to other organism#GO:0051707;biological regulation#GO:0065007;defense response to other organism#GO:0098542;immune response#GO:0006955;defense response to symbiont#GO:0140546;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;response to stress#GO:0006950;response to biotic stimulus#GO:0009607 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=21348|UniProtKB=Q71F23 Q71F23 CENPU PTHR32222:SF1 CENTROMERE PROTEIN U CENTROMERE PROTEIN U nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=12476|UniProtKB=P61077 P61077 UBE2D3 PTHR24068:SF543 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2 D3 acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-like protein conjugating enzyme activity#GO:0061650;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin conjugating enzyme activity#GO:0061631;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 protein modification by small protein conjugation or removal#GO:0070647;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein K11-linked ubiquitination#GO:0070979;primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;metabolic process#GO:0008152;protein K48-linked ubiquitination#GO:0070936;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;cellular process#GO:0009987;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687 ubiquitin-protein ligase#PC00234 Ubiquitin proteasome pathway#P00060>E2#P01491 HUMAN|HGNC=5111|UniProtKB=P14653 P14653 HOXB1 PTHR45946:SF5 HOMEOBOX PROTEIN ROUGH-RELATED HOMEOBOX PROTEIN HOX-B1 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119 HUMAN|HGNC=26543|UniProtKB=Q96M60 Q96M60 FAM227B PTHR33560:SF2 PROTEIN FAM227B PROTEIN FAM227B HUMAN|HGNC=1409|UniProtKB=Q9UF02 Q9UF02 CACNG5 PTHR12107:SF4 VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA SUBUNIT VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-5 SUBUNIT transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;voltage-gated channel activity#GO:0022832;calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;monoatomic cation channel activity#GO:0005261;molecular function regulator activity#GO:0098772;transporter regulator activity#GO:0141108;voltage-gated calcium channel activity#GO:0005245;channel regulator activity#GO:0016247;channel activity#GO:0015267 positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regulation of trans-synaptic signaling#GO:0099177;regulation of postsynaptic membrane neurotransmitter receptor levels#GO:0099072;system process#GO:0003008;transmission of nerve impulse#GO:0019226;regulation of biological process#GO:0050789;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;localization within membrane#GO:0051668;nervous system process#GO:0050877;regulation of signaling#GO:0023051;positive regulation of synaptic transmission#GO:0050806;regulation of biological quality#GO:0065008;cell communication#GO:0007154;localization#GO:0051179;regulation of synaptic transmission, glutamatergic#GO:0051966;positive regulation of signaling#GO:0023056;cellular localization#GO:0051641 membrane protein complex#GO:0098796;postsynapse#GO:0098794;plasma membrane protein complex#GO:0098797;organelle#GO:0043226;asymmetric synapse#GO:0032279;synapse#GO:0045202;cellular anatomical structure#GO:0110165;postsynaptic specialization membrane#GO:0099634;postsynaptic membrane#GO:0045211;postsynaptic density#GO:0014069;transmembrane transporter complex#GO:1902495;postsynaptic density membrane#GO:0098839;membrane#GO:0016020;cell periphery#GO:0071944;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;monoatomic ion channel complex#GO:0034702;neuron to neuron synapse#GO:0098984;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;signaling receptor complex#GO:0043235;synaptic membrane#GO:0097060;cell junction#GO:0030054;transporter complex#GO:1990351 ion channel#PC00133;transporter#PC00227;voltage-gated ion channel#PC00241 Ionotropic glutamate receptor pathway#P00037>stargazin#P00998 HUMAN|HGNC=6442|UniProtKB=P13647 P13647 KRT5 PTHR45616:SF32 GATA-TYPE DOMAIN-CONTAINING PROTEIN KERATIN, TYPE II CYTOSKELETAL 5 structural molecule activity#GO:0005198 intermediate filament cytoskeleton organization#GO:0045104;cell differentiation#GO:0030154;cellular component organization#GO:0016043;anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;keratinocyte differentiation#GO:0030216;animal gross anatomical part developmental process#GO:0160108;intermediate filament-based process#GO:0045103;intermediate filament organization#GO:0045109;tissue development#GO:0009888;multicellular organismal process#GO:0032501;epidermal cell differentiation#GO:0009913;epithelial cell differentiation#GO:0030855;epithelium development#GO:0060429;cytoskeleton organization#GO:0007010;skin development#GO:0043588;organelle organization#GO:0006996;cellular process#GO:0009987;animal organ development#GO:0048513;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;epidermis development#GO:0008544;developmental process#GO:0032502 cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;organelle#GO:0043226;supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;intracellular anatomical structure#GO:0005622;intermediate filament#GO:0005882;supramolecular fiber#GO:0099512;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 HUMAN|HGNC=24432|UniProtKB=P82979 P82979 SARNP PTHR46551:SF2 SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN transport#GO:0006810;metabolic process#GO:0008152;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;poly(A)+ mRNA export from nucleus#GO:0016973;macromolecule metabolic process#GO:0043170;establishment of localization#GO:0051234;establishment of localization in cell#GO:0051649;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule localization#GO:0033036;nitrogen compound transport#GO:0071705;biosynthetic process#GO:0009058;gene expression#GO:0010467;nucleocytoplasmic transport#GO:0006913;nuclear transport#GO:0051169;nuclear export#GO:0051168;localization#GO:0051179;nucleic acid transport#GO:0050657;cellular localization#GO:0051641;mRNA export from nucleus#GO:0006406;establishment of RNA localization#GO:0051236;mRNA transport#GO:0051028;nucleobase-containing compound transport#GO:0015931;RNA localization#GO:0006403;RNA transport#GO:0050658 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=29348|UniProtKB=Q9C0I4 Q9C0I4 THSD7B PTHR11311:SF7 SPONDIN THROMBOSPONDIN TYPE-1 DOMAIN-CONTAINING PROTEIN 7B actin filament-based process#GO:0030029;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;cellular component organization or biogenesis#GO:0071840 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 cell adhesion molecule#PC00069 HUMAN|HGNC=18056|UniProtKB=Q8IZX4 Q8IZX4 TAF1L PTHR13900:SF2 TRANSCRIPTION INITIATION FACTOR TFIID TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1-LIKE protein binding#GO:0005515;binding#GO:0005488;transcription factor binding#GO:0008134 nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;transcription by RNA polymerase II#GO:0006366;protein-DNA complex organization#GO:0071824;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;cellular component biogenesis#GO:0044085;transcription initiation at RNA polymerase II promoter#GO:0006367;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;cellular component assembly#GO:0022607;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;protein-DNA complex assembly#GO:0065004;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;DNA-templated transcription initiation#GO:0006352;DNA-templated transcription#GO:0006351;RNA polymerase II preinitiation complex assembly#GO:0051123;RNA biosynthetic process#GO:0032774 nuclear protein-containing complex#GO:0140513;transcription regulator complex#GO:0005667;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;protein-containing complex#GO:0032991;transcription factor TFIID complex#GO:0005669;membrane-enclosed lumen#GO:0031974;RNA polymerase II transcription regulator complex#GO:0090575;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;RNA polymerase II, holoenzyme#GO:0016591;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029 general transcription factor#PC00259;RNA metabolism protein#PC00031 HUMAN|HGNC=24086|UniProtKB=Q9NQ94 Q9NQ94 A1CF PTHR21245:SF8 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN APOBEC1 COMPLEMENTATION FACTOR mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 RNA metabolism protein#PC00031 HUMAN|HGNC=24634|UniProtKB=Q9UBC2 Q9UBC2 EPS15L1 PTHR11216:SF69 EH DOMAIN EPIDERMAL GROWTH FACTOR RECEPTOR SUBSTRATE 15-LIKE 1 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 cellular process#GO:0009987;establishment of localization in cell#GO:0051649;endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;transport#GO:0006810;establishment of localization#GO:0051234;import into cell#GO:0098657;cellular localization#GO:0051641;localization#GO:0051179;endosomal transport#GO:0016197 clathrin-coated pit#GO:0005905;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;clathrin coat#GO:0030118;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;cytoplasm#GO:0005737;coated membrane#GO:0048475;membrane coat#GO:0030117;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HUMAN|HGNC=12983|UniProtKB=Q15776 Q15776 ZKSCAN8 PTHR23226:SF75 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER PROTEIN WITH KRAB AND SCAN DOMAINS 8 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=24709|UniProtKB=Q5GFL6 Q5GFL6 VWA2 PTHR24020:SF37 COLLAGEN ALPHA VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 2 cell-substrate adhesion#GO:0031589;cell adhesion#GO:0007155;cell-matrix adhesion#GO:0007160;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;basement membrane#GO:0005604;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 extracellular matrix structural protein#PC00103 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>EMC#P00863;Integrin signalling pathway#P00034>Collagen#P00922 HUMAN|HGNC=7698|UniProtKB=O43676 O43676 NDUFB3 PTHR15082:SF2 NADH-UBIQUINONE OXIDOREDUCTASE B12 SUBUNIT NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 3 cellular process#GO:0009987;respiratory electron transport chain#GO:0022904;mitochondrial ATP synthesis coupled electron transport#GO:0042775;electron transport chain#GO:0022900;aerobic respiration#GO:0009060;cellular respiration#GO:0045333;energy derivation by oxidation of organic compounds#GO:0015980;oxidative phosphorylation#GO:0006119;ATP synthesis coupled electron transport#GO:0042773;mitochondrial electron transport, NADH to ubiquinone#GO:0006120;generation of precursor metabolites and energy#GO:0006091;aerobic electron transport chain#GO:0019646;metabolic process#GO:0008152 respiratory chain complex#GO:0098803;oxidoreductase complex#GO:1990204;membrane#GO:0016020;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;respiratory chain complex I#GO:0045271;catalytic complex#GO:1902494;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495 oxidoreductase#PC00176 HUMAN|HGNC=14122|UniProtKB=Q96RY5 Q96RY5 CRAMP1 PTHR21677:SF1 CRAMPED PROTEIN PROTEIN CRAMPED-LIKE chromatin binding#GO:0003682;binding#GO:0005488 developmental process#GO:0032502;pattern specification process#GO:0007389;multicellular organism development#GO:0007275;anatomical structure development#GO:0048856;multicellular organismal process#GO:0032501 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA metabolism protein#PC00009 HUMAN|HGNC=4140|UniProtKB=P17677 P17677 GAP43 PTHR10699:SF15 NEUROMODULIN NEUROMODULIN protein binding#GO:0005515;phosphatidylserine binding#GO:0001786;lipid binding#GO:0008289;ion binding#GO:0043167;anion binding#GO:0043168;binding#GO:0005488;small molecule binding#GO:0036094;phosphatidylinositol phosphate binding#GO:1901981;calmodulin binding#GO:0005516;carbohydrate derivative binding#GO:0097367;phospholipid binding#GO:0005543 multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;axon development#GO:0061564;axon guidance#GO:0007411;cellular developmental process#GO:0048869;developmental growth#GO:0048589;neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;anatomical structure development#GO:0048856;system development#GO:0048731;cell recognition#GO:0008037;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;regeneration#GO:0031099;neuron projection development#GO:0031175;cellular process#GO:0009987;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cell projection morphogenesis#GO:0048858;neuron differentiation#GO:0030182;growth#GO:0040007;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell morphogenesis#GO:0000902;cell development#GO:0048468;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;axonogenesis#GO:0007409;neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;tissue regeneration#GO:0042246 postsynapse#GO:0098794;membrane#GO:0016020;cell periphery#GO:0071944;synapse#GO:0045202;cellular anatomical structure#GO:0110165;neuron to neuron synapse#GO:0098984;asymmetric synapse#GO:0032279;organelle#GO:0043226;postsynaptic specialization#GO:0099572;cytoplasm#GO:0005737;plasma membrane#GO:0005886;postsynaptic density#GO:0014069;cell junction#GO:0030054;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=5184|UniProtKB=Q9Y5N1 Q9Y5N1 HRH3 PTHR24247:SF194 5-HYDROXYTRYPTAMINE RECEPTOR HISTAMINE H3 RECEPTOR G protein-coupled amine receptor activity#GO:0008227;neurotransmitter receptor activity#GO:0030594;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888;postsynaptic neurotransmitter receptor activity#GO:0098960;acetylcholine receptor activity#GO:0015464;molecular transducer activity#GO:0060089 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway#GO:0007193;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;synaptic signaling#GO:0099536;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;cellular process#GO:0009987;response to chemical#GO:0042221;acetylcholine receptor signaling pathway#GO:0095500;cellular response to nitrogen compound#GO:1901699;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;trans-synaptic signaling#GO:0099537;response to oxygen-containing compound#GO:1901700;cell communication#GO:0007154;response to nitrogen compound#GO:1901698;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;anterograde trans-synaptic signaling#GO:0098916;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052 somatodendritic compartment#GO:0036477;cell projection#GO:0042995;plasma membrane#GO:0005886;plasma membrane bounded cell projection#GO:0120025;synapse#GO:0045202;cellular anatomical structure#GO:0110165;neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020;cell junction#GO:0030054;dendritic tree#GO:0097447;dendrite#GO:0030425 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GsPCR#P00720 HUMAN|HGNC=6119|UniProtKB=Q15306 Q15306 IRF4 PTHR11949:SF6 INTERFERON REGULATORY FACTOR INTERFERON REGULATORY FACTOR 4 cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;winged helix/forkhead transcription factor#PC00246 HUMAN|HGNC=14004|UniProtKB=Q9BYT9 Q9BYT9 ANO3 PTHR12308:SF16 ANOCTAMIN ANOCTAMIN-3 intramembrane lipid carrier activity#GO:0140303;transporter activity#GO:0005215;phospholipid scramblase activity#GO:0017128;lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104 regulation of membrane lipid distribution#GO:0097035;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;transport#GO:0006810;biological regulation#GO:0065007;membrane organization#GO:0061024;phospholipid transport#GO:0015914;phospholipid translocation#GO:0045332;lipid transport#GO:0006869;cellular process#GO:0009987;macromolecule localization#GO:0033036;regulation of biological quality#GO:0065008;localization#GO:0051179;lipid localization#GO:0010876;lipid translocation#GO:0034204;organophosphate ester transport#GO:0015748;cellular component organization#GO:0016043 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 ion channel#PC00133;transporter#PC00227 HUMAN|HGNC=25217|UniProtKB=Q9UKZ1 Q9UKZ1 CNOT11 PTHR15975:SF0 CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 11 CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 11 post-transcriptional regulation of gene expression#GO:0010608;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;CCR4-NOT complex#GO:0030014 HUMAN|HGNC=29941|UniProtKB=Q8WUU5 Q8WUU5 GATAD1 PTHR13340:SF2 GATA ZINC FINGER DOMAIN-CONTAINING GATA ZINC FINGER DOMAIN-CONTAINING PROTEIN 1 chromatin organization#GO:0006325;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=6835|UniProtKB=P78559 P78559 MAP1A PTHR13843:SF6 MICROTUBULE-ASSOCIATED PROTEIN MICROTUBULE-ASSOCIATED PROTEIN 1A cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;tubulin binding#GO:0015631;microtubule binding#GO:0008017;binding#GO:0005488;protein binding#GO:0005515 plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;microtubule-based process#GO:0007017;cell projection morphogenesis#GO:0048858;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;organelle organization#GO:0006996;regulation of protein-containing complex disassembly#GO:0043244;neuron projection development#GO:0031175;nervous system development#GO:0007399;regulation of microtubule cytoskeleton organization#GO:0070507;cell morphogenesis involved in neuron differentiation#GO:0048667;cytoskeleton organization#GO:0007010;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;axonogenesis#GO:0007409;neuron development#GO:0048666;dendrite development#GO:0016358;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;cell development#GO:0048468;cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;cell differentiation#GO:0030154;regulation of cellular component organization#GO:0051128;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;regulation of protein depolymerization#GO:1901879;regulation of microtubule polymerization or depolymerization#GO:0031110;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;axon development#GO:0061564;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regulation of microtubule-based process#GO:0032886;system development#GO:0048731;microtubule cytoskeleton organization#GO:0000226;anatomical structure development#GO:0048856;regulation of supramolecular fiber organization#GO:1902903;regulation of cellular process#GO:0050794;regulation of cytoskeleton organization#GO:0051493 microtubule cytoskeleton#GO:0015630;cytosol#GO:0005829;neuron projection#GO:0043005;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;somatodendritic compartment#GO:0036477;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;cytoskeleton#GO:0005856;cell junction#GO:0030054;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;cell body#GO:0044297;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;neuronal cell body#GO:0043025;plasma membrane bounded cell projection#GO:0120025;dendrite#GO:0030425;intracellular organelle#GO:0043229;dendritic tree#GO:0097447;microtubule#GO:0005874;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622 non-motor microtubule binding protein#PC00166;cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=24660|UniProtKB=Q8IX06 Q8IX06 REXO1L1P PTHR12801:SF22 RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED EXONUCLEASE GOR-RELATED nuclease activity#GO:0004518;hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;exonuclease activity#GO:0004527;catalytic activity, acting on a nucleic acid#GO:0140640 cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;cellular component organization or biogenesis#GO:0071840;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 RNA metabolism protein#PC00031;exoribonuclease#PC00099 HUMAN|HGNC=51245|UniProtKB=A0A087X1G2 A0A087X1G2 TBC1D3K PTHR22957:SF571 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN TBC1 DOMAIN FAMILY MEMBER 3-RELATED molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;enzyme activator activity#GO:0008047 protein-binding activity modulator#PC00095;G-protein modulator#PC00022;GTPase-activating protein#PC00257 HUMAN|HGNC=9206|UniProtKB=Q15166 Q15166 PON3 PTHR11799:SF14 PARAOXONASE SERUM PARAOXONASE_LACTONASE 3 hydrolase activity, acting on ester bonds#GO:0016788;carboxylic ester hydrolase activity#GO:0052689;catalytic activity#GO:0003824;hydrolase activity#GO:0016787 oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;carboxylic acid metabolic process#GO:0019752;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;response to toxic substance#GO:0009636;response to stimulus#GO:0050896;small molecule metabolic process#GO:0044281;response to chemical#GO:0042221;catabolic process#GO:0009056;small molecule catabolic process#GO:0044282 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HUMAN|HGNC=8276|UniProtKB=Q9NQN1 Q9NQN1 OR2S2 PTHR26453:SF176 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2S2 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;detection of chemical stimulus#GO:0009593;response to stimulus#GO:0050896;response to chemical#GO:0042221;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception#GO:0007600;nervous system process#GO:0050877;system process#GO:0003008 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=29000|UniProtKB=O14523 O14523 C2CD2L PTHR21119:SF8 C2 DOMAIN-CONTAINING PROTEIN PHOSPHOLIPID TRANSFER PROTEIN C2CD2L lipid transfer activity#GO:0120013;binding#GO:0005488;anion binding#GO:0043168;small molecule binding#GO:0036094;molecular carrier activity#GO:0140104;lipid carrier activity#GO:0005319;ion binding#GO:0043167;phosphatidylinositol transfer activity#GO:0008526;transporter activity#GO:0005215;phosphatidylinositol binding#GO:0035091 regulation of protein localization#GO:0032880;regulation of establishment of protein localization#GO:0070201;regulation of biological quality#GO:0065008;regulation of secretion by cell#GO:1903530;regulation of hormone secretion#GO:0046883;regulation of secretion#GO:0051046;positive regulation of signaling#GO:0023056;positive regulation of secretion#GO:0051047;positive regulation of hormone secretion#GO:0046887;regulation of signaling#GO:0023051;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of protein transport#GO:0051223;positive regulation of cell communication#GO:0010647;regulation of biological process#GO:0050789;regulation of hormone levels#GO:0010817;regulation of protein secretion#GO:0050708;regulation of localization#GO:0032879;regulation of transport#GO:0051049;positive regulation of protein secretion#GO:0050714;biological regulation#GO:0065007;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of transport#GO:0051050;positive regulation of secretion by cell#GO:1903532;regulation of insulin secretion#GO:0050796 side of membrane#GO:0098552;cytoplasmic side of membrane#GO:0098562;apical part of cell#GO:0045177;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;cell periphery#GO:0071944;membrane#GO:0016020;cytoplasmic side of plasma membrane#GO:0009898;apical plasma membrane#GO:0016324 HUMAN|HGNC=21156|UniProtKB=Q9BYE7 Q9BYE7 PCGF6 PTHR45893:SF2 POLYCOMB GROUP RING FINGER PROTEIN POLYCOMB GROUP RING FINGER PROTEIN 6 negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear ubiquitin ligase complex#GO:0000152;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ubiquitin ligase complex#GO:0000151;nucleus#GO:0005634;PcG protein complex#GO:0031519;protein-containing complex#GO:0032991;transferase complex#GO:1990234;PRC1 complex#GO:0035102;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513 histone modifying enzyme#PC00261;chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=11906|UniProtKB=O14798 O14798 TNFRSF10C PTHR46330:SF13 TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10B TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10A-RELATED extrinsic apoptotic signaling pathway#GO:0097191;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;positive regulation of programmed cell death#GO:0043068;signaling#GO:0023052;regulation of programmed cell death#GO:0043067;programmed cell death#GO:0012501;regulation of biological process#GO:0050789;cell death#GO:0008219;apoptotic process#GO:0006915;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;biological regulation#GO:0065007;positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of apoptotic process#GO:0043065;apoptotic signaling pathway#GO:0097190;extrinsic apoptotic signaling pathway via death domain receptors#GO:0008625;cell surface receptor signaling pathway#GO:0007166;regulation of apoptotic process#GO:0042981 plasma membrane#GO:0005886;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 Apoptosis signaling pathway#P00006>TRAIL-R#P00276;p53 pathway#P00059>KILLER/DR5#G01568 HUMAN|HGNC=21185|UniProtKB=Q8NA58 Q8NA58 PNLDC1 PTHR15092:SF50 POLY A -SPECIFIC RIBONUCLEASE/TARGET OF EGR1, MEMBER 1 POLY(A)-SPECIFIC RIBONUCLEASE PNLDC1 nuclease activity#GO:0004518;RNA binding#GO:0003723;hydrolase activity#GO:0016787;3'-5'-RNA exonuclease activity#GO:0000175;nucleic acid binding#GO:0003676;binding#GO:0005488;exonuclease activity#GO:0004527;3'-5' exonuclease activity#GO:0008408;catalytic activity, acting on RNA#GO:0140098;RNA nuclease activity#GO:0004540;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640 regulation of RNA metabolic process#GO:0051252;regulation of RNA stability#GO:0043487;RNA biosynthetic process#GO:0032774;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;nuclear-transcribed mRNA poly(A) tail shortening#GO:0000289;regulation of cellular process#GO:0050794;positive regulation of mRNA catabolic process#GO:0061014;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;macromolecule metabolic process#GO:0043170;regulatory ncRNA processing#GO:0070918;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;positive regulation of catabolic process#GO:0009896;regulatory ncRNA-mediated gene silencing#GO:0031047;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;macromolecule biosynthetic process#GO:0009059;nucleic acid catabolic process#GO:0141188;nucleobase-containing compound catabolic process#GO:0034655;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological quality#GO:0065008;positive regulation of metabolic process#GO:0009893;RNA metabolic process#GO:0016070;RNA catabolic process#GO:0006401;nucleic acid biosynthetic process#GO:0141187;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;regulation of mRNA stability#GO:0043488;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;negative regulation of gene expression#GO:0010629;RNA 3'-end processing#GO:0031123;regulation of mRNA metabolic process#GO:1903311;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;mRNA destabilization#GO:0061157;nucleobase-containing compound biosynthetic process#GO:0034654;positive regulation of mRNA metabolic process#GO:1903313;RNA processing#GO:0006396;positive regulation of macromolecule metabolic process#GO:0010604;gene expression#GO:0010467;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;RNA destabilization#GO:0050779 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 mRNA polyadenylation factor#PC00146 HUMAN|HGNC=23146|UniProtKB=Q86WK9 Q86WK9 PAQR7 PTHR20855:SF41 ADIPOR/PROGESTIN RECEPTOR-RELATED MEMBRANE PROGESTIN RECEPTOR ALPHA molecular transducer activity#GO:0060089;nuclear receptor activity#GO:0004879;lipid binding#GO:0008289;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulator activity#GO:0140110;steroid binding#GO:0005496;signaling receptor activity#GO:0038023 response to endogenous stimulus#GO:0009719;response to steroid hormone#GO:0048545;response to hormone#GO:0009725;response to stimulus#GO:0050896;response to chemical#GO:0042221;response to lipid#GO:0033993 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=9407|UniProtKB=Q15139 Q15139 PRKD1 PTHR22968:SF9 PROTEIN KINASE C, MU SERINE_THREONINE-PROTEIN KINASE D1 kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 phospholipase C-activating G protein-coupled receptor signaling pathway#GO:0007200;G protein-coupled receptor signaling pathway#GO:0007186;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 CCKR signaling map#P06959>PRKD1#P07103;EGF receptor signaling pathway#P00018>PKC#P00565;VEGF signaling pathway#P00056>PKC#P01425;Angiogenesis#P00005>PKC#P00219 HUMAN|HGNC=15228|UniProtKB=Q8NGI0 Q8NGI0 OR52N2 PTHR26450:SF161 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 52N2 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=11581|UniProtKB=Q9BTW9 Q9BTW9 TBCD PTHR12658:SF1 BETA-TUBULIN COFACTOR D TUBULIN-SPECIFIC CHAPERONE D binding#GO:0005488;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;protein binding#GO:0005515;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;enzyme activator activity#GO:0008047;molecular function regulator activity#GO:0098772;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096 gene expression#GO:0010467;protein maturation#GO:0051604;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;biosynthetic process#GO:0009058;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;metabolic process#GO:0008152;cell-cell junction assembly#GO:0007043;cell-cell junction organization#GO:0045216;cell junction organization#GO:0034330;protein folding#GO:0006457;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;adherens junction organization#GO:0034332;cell junction assembly#GO:0034329;microtubule cytoskeleton organization#GO:0000226;protein metabolic process#GO:0019538 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 chaperone#PC00072 HUMAN|HGNC=30950|UniProtKB=Q9UID6 Q9UID6 ZNF639 PTHR24404:SF35 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 639 RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892 DNA-binding transcription factor#PC00218;C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HUMAN|HGNC=9177|UniProtKB=Q07864 Q07864 POLE PTHR10670:SF0 DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A transferase activity#GO:0016740;DNA exonuclease activity#GO:0004529;DNA polymerase activity#GO:0034061;catalytic activity, acting on DNA#GO:0140097;3'-5' exonuclease activity#GO:0008408;exonuclease activity#GO:0004527;3'-5'-DNA exonuclease activity#GO:0008296;DNA exonuclease activity, producing 5'-phosphomonoesters#GO:0016895;nuclease activity#GO:0004518;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;nucleotidyltransferase activity#GO:0016779;DNA nuclease activity#GO:0004536;transferase activity, transferring phosphorus-containing groups#GO:0016772;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;DNA-directed DNA polymerase activity#GO:0003887 DNA-templated DNA replication#GO:0006261;cellular response to stress#GO:0033554;DNA strand elongation involved in DNA replication#GO:0006271;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;DNA replication#GO:0006260;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;base-excision repair#GO:0006284;macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;nucleotide-excision repair#GO:0006289;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;response to stress#GO:0006950 intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;epsilon DNA polymerase complex#GO:0008622;membraneless organelle#GO:0043228;transferase complex#GO:1990234;DNA polymerase complex#GO:0042575;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle lumen#GO:0043233;chromosome#GO:0005694 DNA metabolism protein#PC00009 HUMAN|HGNC=1339|UniProtKB=P13671 P13671 C6 PTHR45742:SF4 COMPLEMENT COMPONENT C6 COMPLEMENT COMPONENT C6 regulation of response to stimulus#GO:0048583;immune effector process#GO:0002252;positive regulation of immune response#GO:0050778;humoral immune response#GO:0006959;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;activation of immune response#GO:0002253;complement activation#GO:0006956;positive regulation of biological process#GO:0048518;immune response#GO:0006955;positive regulation of immune system process#GO:0002684;regulation of immune response#GO:0050776;immune system process#GO:0002376;regulation of immune system process#GO:0002682;response to stimulus#GO:0050896;regulation of biological process#GO:0050789 extracellular region#GO:0005576;membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 complement component#PC00078 HUMAN|HGNC=8831|UniProtKB=P01210 P01210 PENK PTHR11438:SF3 PROENKEPHALIN PROENKEPHALIN-A signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;G protein-coupled receptor binding#GO:0001664;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;molecular function activator activity#GO:0140677;protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488 biological regulation#GO:0065007;multicellular organismal process#GO:0032501;cellular process#GO:0009987;signal transduction#GO:0007165;system process#GO:0003008;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;neuropeptide signaling pathway#GO:0007218;sensory perception of pain#GO:0019233;cell communication#GO:0007154;nervous system process#GO:0050877;sensory perception#GO:0007600;G protein-coupled receptor signaling pathway#GO:0007186 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;cell body#GO:0044297;vesicle#GO:0031982;intracellular vesicle#GO:0097708;organelle lumen#GO:0043233;neuronal cell body#GO:0043025;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;secretory vesicle#GO:0099503;membrane-enclosed lumen#GO:0031974;somatodendritic compartment#GO:0036477;cytoplasm#GO:0005737;endomembrane system#GO:0012505 peptide hormone#PC00179;neuropeptide#PC00162;intercellular signal molecule#PC00207 Opioid proenkephalin pathway#P05915>proenkephalin#P05995;Opioid proenkephalin pathway#P05915>Enkephalin#P05991;Enkephalin release#P05913>preproenkephalin mRNA#G06046;Enkephalin release#P05913>preproenkephalin#G06045;Opioid proenkephalin pathway#P05915>peptide F#P05987;Opioid proenkephalin pathway#P05915>leu-Enkephalin#P05989;Enkephalin release#P05913>Enkephalin#P05976;Opioid proenkephalin pathway#P05915>met-Enkephalin#P05992;Opioid proenkephalin pathway#P05915>peptide E#P05988 HUMAN|HGNC=24862|UniProtKB=Q13724 Q13724 MOGS PTHR10412:SF11 MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;glucosidase activity#GO:0015926;catalytic activity#GO:0003824;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787;alpha-glucosidase activity#GO:0090599 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;protein N-linked glycosylation#GO:0006487;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;biosynthetic process#GO:0009058;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229 glucosidase#PC00108;hydrolase#PC00121 HUMAN|HGNC=10972|UniProtKB=Q8TCC7 Q8TCC7 SLC22A8 PTHR24064:SF439 SOLUTE CARRIER FAMILY 22 MEMBER ORGANIC ANION TRANSPORTER 3 active transmembrane transporter activity#GO:0022804;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;antiporter activity#GO:0015297 cellular process#GO:0009987;transport#GO:0006810;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 secondary carrier transporter#PC00258 HUMAN|HGNC=18682|UniProtKB=Q9H0S4 Q9H0S4 DDX47 PTHR24031:SF790 RNA HELICASE ATP-DEPENDENT RNA HELICASE DDX47-RELATED ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 RNA metabolism protein#PC00031;RNA helicase#PC00032 HUMAN|HGNC=41|UniProtKB=Q9NRK6 Q9NRK6 ABCB10 PTHR43394:SF29 ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL regulation of multicellular organismal development#GO:2000026;regulation of biological process#GO:0050789;heme biosynthetic process#GO:0006783;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;tetrapyrrole biosynthetic process#GO:0033014;regulation of myeloid cell differentiation#GO:0045637;tetrapyrrole metabolic process#GO:0033013;porphyrin-containing compound biosynthetic process#GO:0006779;regulation of hemopoiesis#GO:1903706;regulation of cell development#GO:0060284;cellular process#GO:0009987;positive regulation of myeloid cell differentiation#GO:0045639;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;pigment metabolic process#GO:0042440;regulation of multicellular organismal process#GO:0051239;biosynthetic process#GO:0009058;heme metabolic process#GO:0042168;biological regulation#GO:0065007;porphyrin-containing compound metabolic process#GO:0006778;positive regulation of cell differentiation#GO:0045597;regulation of cell differentiation#GO:0045595;positive regulation of developmental process#GO:0051094;pigment biosynthetic process#GO:0046148;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrial inner membrane#GO:0005743;organelle envelope#GO:0031967;membrane#GO:0016020;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866 HUMAN|HGNC=8514|UniProtKB=O75508 O75508 CLDN11 PTHR12002:SF6 CLAUDIN CLAUDIN-11 cell-cell junction assembly#GO:0007043;cell-cell junction organization#GO:0045216;cell adhesion#GO:0007155;cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;cell junction assembly#GO:0034329;cellular process#GO:0009987;cell junction organization#GO:0034330;cellular component assembly#GO:0022607 apical junction complex#GO:0043296;tight junction#GO:0070160;cell junction#GO:0030054;anchoring junction#GO:0070161;membrane#GO:0016020;cell-cell junction#GO:0005911;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;bicellular tight junction#GO:0005923;plasma membrane#GO:0005886 tight junction#PC00214;cell junction protein#PC00070 HUMAN|HGNC=8282|UniProtKB=P47881 P47881 OR3A1 PTHR48001:SF226 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 3A1 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell communication#GO:0007154;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=18709|UniProtKB=Q8WWL7 Q8WWL7 CCNB3 PTHR10177:SF214 CYCLINS G2_MITOTIC-SPECIFIC CYCLIN-B3 enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;protein kinase regulator activity#GO:0019887;cyclin-dependent protein kinase regulator activity#GO:0019914;cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538 mitotic cell cycle#GO:0000278;cell cycle phase transition#GO:0044770;cell cycle#GO:0007049;cell cycle G1/S phase transition#GO:0044843;cell cycle process#GO:0022402;cellular process#GO:0009987;mitotic cell cycle process#GO:1903047;mitotic cell cycle phase transition#GO:0044772;G1/S transition of mitotic cell cycle#GO:0000082 transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle#GO:0043229;protein kinase complex#GO:1902911;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cyclin-dependent protein kinase holoenzyme complex#GO:0000307 kinase activator#PC00138 HUMAN|HGNC=29551|UniProtKB=Q3YBR2 Q3YBR2 TBRG1 PTHR22715:SF0 TRANSFORMING GROWTH FACTOR BETA REGULATED GENE 1 TRANSFORMING GROWTH FACTOR BETA REGULATOR 1 regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cell cycle#GO:0051726;biological regulation#GO:0065007 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 growth factor#PC00112;intercellular signal molecule#PC00207 HUMAN|HGNC=15905|UniProtKB=Q9Y468 Q9Y468 L3MBTL1 PTHR12247:SF69 POLYCOMB GROUP PROTEIN LETHAL(3)MALIGNANT BRAIN TUMOR-LIKE PROTEIN 1 protein binding#GO:0005515;chromatin binding#GO:0003682;histone binding#GO:0042393;binding#GO:0005488 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=30595|UniProtKB=Q6ZMI0 Q6ZMI0 PPP1R21 PTHR21448:SF0 SMOOTH MUSCLE MYOSIN HEAVY CHAIN-RELATED PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 21 vesicle#GO:0031982;membrane#GO:0016020;intracellular vesicle#GO:0097708;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;early endosome#GO:0005769 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=25850|UniProtKB=Q9H871 Q9H871 RMND5A PTHR12170:SF5 MACROPHAGE ERYTHROBLAST ATTACHER-RELATED E3 UBIQUITIN-PROTEIN TRANSFERASE RMND5A ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;ubiquitin-protein transferase activity#GO:0004842;catalytic activity, acting on a protein#GO:0140096 proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152 nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227;ubiquitin ligase complex#GO:0000151 HUMAN|HGNC=14280|UniProtKB=O76071 O76071 CIAO1 PTHR19920:SF0 WD40 PROTEIN CIAO1 CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;iron-sulfur cluster assembly#GO:0016226 cytoplasm#GO:0005737;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 HUMAN|HGNC=20318|UniProtKB=Q9H4F8 Q9H4F8 SMOC1 PTHR12352:SF13 SECRETED MODULAR CALCIUM-BINDING PROTEIN SPARC-RELATED MODULAR CALCIUM-BINDING PROTEIN 1 extracellular matrix binding#GO:0050840;heparin binding#GO:0008201;binding#GO:0005488;glycosaminoglycan binding#GO:0005539;carbohydrate derivative binding#GO:0097367 extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;external encapsulating structure organization#GO:0045229;cellular component organization#GO:0016043;extracellular structure organization#GO:0043062;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;basement membrane#GO:0005604;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 calmodulin-related#PC00061 HUMAN|HGNC=5103|UniProtKB=O43364 O43364 HOXA2 PTHR45664:SF3 PROTEIN ZERKNUELLT 1-RELATED HOMEOBOX PROTEIN HOX-A2 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 homeodomain transcription factor#PC00119 HUMAN|HGNC=24791|UniProtKB=Q3MJ16 Q3MJ16 PLA2G4E PTHR10728:SF24 CYTOSOLIC PHOSPHOLIPASE A2 CYTOSOLIC PHOSPHOLIPASE A2 EPSILON hydrolase activity, acting on ester bonds#GO:0016788;phospholipid binding#GO:0005543;catalytic activity#GO:0003824;cation binding#GO:0043169;hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689;lipase activity#GO:0016298;small molecule binding#GO:0036094;ion binding#GO:0043167;A2-type glycerophospholipase activity#GO:0004623;phospholipase activity#GO:0120569;glycerophospholipase activity#GO:0004620;lipid binding#GO:0008289;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;binding#GO:0005488 metabolic process#GO:0008152;glycerolipid catabolic process#GO:0046503;lipid metabolic process#GO:0006629;glycerophospholipid catabolic process#GO:0046475;organophosphate catabolic process#GO:0046434;organophosphate metabolic process#GO:0019637;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;lipid catabolic process#GO:0016042;cellular process#GO:0009987;phospholipid catabolic process#GO:0009395;glycerophospholipid metabolic process#GO:0006650;glycerolipid metabolic process#GO:0046486;catabolic process#GO:0009056;phospholipid metabolic process#GO:0006644 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 phospholipase#PC00186 HUMAN|HGNC=5755|UniProtKB=P0DSN7 P0DSN7 IGKV1D-37 PTHR23267:SF468 IMMUNOGLOBULIN LIGHT CHAIN NON-FUNCTIONAL IMMUNOGLOBULIN KAPPA VARIABLE 1-37-RELATED immune system process#GO:0002376;immune response#GO:0006955;response to stimulus#GO:0050896 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=33100|UniProtKB=Q8TED1 Q8TED1 GPX8 PTHR11592:SF7 GLUTATHIONE PEROXIDASE PROTEIN PEROXIDASE GPX8 catalytic activity#GO:0003824;peroxidase activity#GO:0004601;antioxidant activity#GO:0016209;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on peroxide as acceptor#GO:0016684 response to stress#GO:0006950;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cellular response to oxidative stress#GO:0034599;response to stimulus#GO:0050896;response to chemical#GO:0042221;cellular response to chemical stimulus#GO:0070887;cellular response to stress#GO:0033554;cellular response to chemical stress#GO:0062197;response to oxidative stress#GO:0006979 peroxidase#PC00180;oxidoreductase#PC00176 HUMAN|HGNC=4908|UniProtKB=Q6NVY1 Q6NVY1 HIBCH PTHR43176:SF15 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL thiolester hydrolase activity#GO:0016790;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;fatty acyl-CoA hydrolase activity#GO:0047617;acyl-CoA hydrolase activity#GO:0016289;deacylase activity#GO:0160215;hydrolase activity#GO:0016787 metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;proteinogenic amino acid metabolic process#GO:0170039;amino acid metabolic process#GO:0006520;small molecule catabolic process#GO:0044282 mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 hydrolase#PC00121 HUMAN|HGNC=24500|UniProtKB=Q69YN4 Q69YN4 VIRMA PTHR23185:SF0 PROTEIN VIRILIZER HOMOLOG PROTEIN VIRILIZER HOMOLOG transferase complex#GO:1990234;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;methyltransferase complex#GO:0034708;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=19057|UniProtKB=Q8TD26 Q8TD26 CHD6 PTHR45623:SF8 CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED ATP-DEPENDENT CHROMATIN REMODELER CHD6 ATP hydrolysis activity#GO:0016887;DNA binding#GO:0003677;hydrolase activity#GO:0016787;chromatin binding#GO:0003682;nucleic acid binding#GO:0003676;ribonucleoside triphosphate phosphatase activity#GO:0017111;histone binding#GO:0042393;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;pyrophosphatase activity#GO:0016462;protein binding#GO:0005515;ATP-dependent activity, acting on DNA#GO:0008094;ATP-dependent activity#GO:0140657;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity, acting on DNA#GO:0140097;hydrolase activity, acting on acid anhydrides#GO:0016817 regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;chromatin remodeling#GO:0006338;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of macromolecule biosynthetic process#GO:0010556;cellular component organization#GO:0016043;regulation of metabolic process#GO:0019222;cellular process#GO:0009987;regulation of biological process#GO:0050789 intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=28957|UniProtKB=Q8N766 Q8N766 EMC1 PTHR21573:SF0 ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1 ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1 membrane insertase activity#GO:0032977;protein carrier activity#GO:0140597;molecular carrier activity#GO:0140104 cellular component organization#GO:0016043;protein insertion into ER membrane#GO:0045048;endoplasmic reticulum organization#GO:0007029;protein localization to organelle#GO:0033365;localization within membrane#GO:0051668;localization#GO:0051179;cellular localization#GO:0051641;establishment of protein localization to membrane#GO:0090150;organelle organization#GO:0006996;macromolecule localization#GO:0033036;establishment of protein localization#GO:0045184;cellular process#GO:0009987;tail-anchored membrane protein insertion into ER membrane#GO:0071816;protein insertion into membrane#GO:0051205;membrane organization#GO:0061024;endomembrane system organization#GO:0010256;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104 EMC complex#GO:0072546;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;membrane protein complex#GO:0098796;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;organelle membrane#GO:0031090;endoplasmic reticulum protein-containing complex#GO:0140534;membrane#GO:0016020;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasm#GO:0005737 HUMAN|HGNC=6222|UniProtKB=P22459 P22459 KCNA4 PTHR11537:SF284 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 4 metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;potassium channel activity#GO:0005267 transport#GO:0006810;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;cellular process#GO:0009987;potassium ion transport#GO:0006813;biological regulation#GO:0065007;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;monoatomic ion transmembrane transport#GO:0034220;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;action potential#GO:0001508;metal ion transport#GO:0030001 membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;cation channel complex#GO:0034703;voltage-gated potassium channel complex#GO:0008076;cell junction#GO:0030054;transporter complex#GO:1990351;membrane protein complex#GO:0098796;postsynapse#GO:0098794;plasma membrane protein complex#GO:0098797;dendritic spine#GO:0043197;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;neuron spine#GO:0044309;dendrite#GO:0030425;axon#GO:0030424;dendritic tree#GO:0097447;transmembrane transporter complex#GO:1902495 ion channel#PC00133;voltage-gated ion channel#PC00241 HUMAN|HGNC=20166|UniProtKB=O15037 O15037 KHNYN PTHR12876:SF28 N4BP1-RELATED PROTEIN KHNYN RNA nuclease activity#GO:0004540;endonuclease activity#GO:0004519;catalytic activity, acting on RNA#GO:0140098;RNA endonuclease activity#GO:0004521;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;nuclease activity#GO:0004518;RNA binding#GO:0003723;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of RNA stability#GO:0043487;regulation of RNA metabolic process#GO:0051252;positive regulation of mRNA catabolic process#GO:0061014;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;positive regulation of catabolic process#GO:0009896;regulation of biosynthetic process#GO:0009889;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;positive regulation of metabolic process#GO:0009893;regulation of biological quality#GO:0065008;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;negative regulation of metabolic process#GO:0009892;regulation of mRNA stability#GO:0043488;mRNA destabilization#GO:0061157;positive regulation of mRNA metabolic process#GO:1903313;regulation of mRNA metabolic process#GO:1903311;negative regulation of macromolecule biosynthetic process#GO:0010558;RNA destabilization#GO:0050779;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604 membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;supramolecular complex#GO:0099080;organelle#GO:0043226;ribonucleoprotein granule#GO:0035770;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 endoribonuclease#PC00094 HUMAN|HGNC=20860|UniProtKB=Q504Y0 Q504Y0 SLC39A12 PTHR12191:SF4 SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER ZIP12 transition metal ion transmembrane transporter activity#GO:0046915;symporter activity#GO:0015293;monoatomic cation transmembrane transporter activity#GO:0008324;zinc ion transmembrane transporter activity#GO:0005385;bicarbonate transmembrane transporter activity#GO:0015106;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;solute:monoatomic cation symporter activity#GO:0015294;monoatomic ion transmembrane transporter activity#GO:0015075;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873 monoatomic cation transmembrane transport#GO:0098655;zinc ion transport#GO:0006829;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;inorganic cation import across plasma membrane#GO:0098659;import into cell#GO:0098657;establishment of localization#GO:0051234;transport#GO:0006810;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;homeostatic process#GO:0042592;metal ion transport#GO:0030001;inorganic ion import across plasma membrane#GO:0099587;import across plasma membrane#GO:0098739;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;zinc ion transmembrane transport#GO:0071577;transition metal ion transport#GO:0000041 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 HUMAN|HGNC=16452|UniProtKB=P0DN86 P0DN86 CGB3 PTHR11515:SF25 GLYCOPROTEIN HORMONE BETA CHAIN CHORIOGONADOTROPIN SUBUNIT BETA 3-RELATED molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;hormone activity#GO:0005179;signaling receptor activator activity#GO:0030546;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018 anatomical structure development#GO:0048856;cell communication#GO:0007154;reproductive system development#GO:0061458;female gonad development#GO:0008585;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;G protein-coupled receptor signaling pathway#GO:0007186;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;reproductive process#GO:0022414;reproductive structure development#GO:0048608;signaling#GO:0023052;developmental process involved in reproduction#GO:0003006;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;animal organ development#GO:0048513;multicellular organism development#GO:0007275;development of primary sexual characteristics#GO:0045137;developmental process#GO:0032502;multicellular organismal process#GO:0032501;gonad development#GO:0008406;biological regulation#GO:0065007;sex differentiation#GO:0007548;cellular process#GO:0009987;signal transduction#GO:0007165 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 peptide hormone#PC00179 HUMAN|HGNC=13915|UniProtKB=Q9BXR3 Q9BXR3 ERVK-6 PTHR41694:SF3 ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN ENDOGENOUS RETROVIRUS GROUP K MEMBER 10 POL PROTEIN-RELATED binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 viral or transposable element protein#PC00237 HUMAN|HGNC=10425|UniProtKB=P22090 P22090 RPS4Y1 PTHR11581:SF8 30S/40S RIBOSOMAL PROTEIN S4 SMALL RIBOSOMAL SUBUNIT PROTEIN ES4, Y ISOFORM 1 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 translation#GO:0006412;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein biosynthetic process#GO:0160307 cytosolic ribosome#GO:0022626;cytosol#GO:0005829;ribosome#GO:0005840;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;ribonucleoprotein complex#GO:1990904;cytosolic small ribosomal subunit#GO:0022627;intracellular organelle#GO:0043229;small ribosomal subunit#GO:0015935;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202 HUMAN|HGNC=2810|UniProtKB=O60443 O60443 GSDME PTHR15207:SF1 NONSYNDROMIC HEARING IMPAIRMENT PROTEIN GASDERMIN-E wide pore channel activity#GO:0022829;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 defense response#GO:0006952;response to stimulus#GO:0050896;inflammatory response#GO:0006954;cell death#GO:0008219;cellular process#GO:0009987;response to stress#GO:0006950;programmed cell death#GO:0012501 cellular anatomical structure#GO:0110165;membrane#GO:0016020 HUMAN|HGNC=27018|UniProtKB=Q8NI32 Q8NI32 LYPD6B PTHR31171:SF3 LY6/PLAUR DOMAIN-CONTAINING PROTEIN 6 LY6_PLAUR DOMAIN-CONTAINING PROTEIN 6B molecular function regulator activity#GO:0098772;neurotransmitter receptor regulator activity#GO:0099602;acetylcholine receptor regulator activity#GO:0030548;signaling receptor regulator activity#GO:0030545 HUMAN|HGNC=5620|UniProtKB=P01780 P01780 IGHV3-7 PTHR23266:SF223 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 3-7 antigen binding#GO:0003823;binding#GO:0005488 response to stimulus#GO:0050896;adaptive immune response#GO:0002250;immune response#GO:0006955;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;immunoglobulin mediated immune response#GO:0016064;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immune system process#GO:0002376;immune effector process#GO:0002252 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=12659|UniProtKB=Q9UKW4 Q9UKW4 VAV3 PTHR45818:SF1 PROTEIN VAV GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV3 guanyl-nucleotide exchange factor activity#GO:0005085;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772 small GTPase-mediated signal transduction#GO:0007264;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;positive regulation of response to stimulus#GO:0048584;cell migration#GO:0016477;positive regulation of cellular process#GO:0048522;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;regulation of cell communication#GO:0010646;cell motility#GO:0048870;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;positive regulation of cell communication#GO:0010647;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051896;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;regulation of immune response#GO:0050776;intracellular signaling cassette#GO:0141124;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;cell surface receptor signaling pathway#GO:0007166;signaling#GO:0023052;positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051897;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;immune response-regulating signaling pathway#GO:0002764;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531 plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 T cell activation#P00053>vav#P01295;PDGF signaling pathway#P00047>Vav#P01169;B cell activation#P00010>vav#P00368 HUMAN|HGNC=18162|UniProtKB=Q86UV7 Q86UV7 TRIM73 PTHR24103:SF662 E3 UBIQUITIN-PROTEIN LIGASE TRIM TRIPARTITE MOTIF-CONTAINING PROTEIN 73-RELATED ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 innate immune response#GO:0045087;defense response#GO:0006952;response to external stimulus#GO:0009605;immune system process#GO:0002376;defense response to other organism#GO:0098542;response to stimulus#GO:0050896;response to other organism#GO:0051707;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;defense response to symbiont#GO:0140546;immune response#GO:0006955 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=26705|UniProtKB=Q6UXN8 Q6UXN8 CLEC9A PTHR47727:SF1 C-TYPE LECTIN DOMAIN FAMILY 9 MEMBER A C-TYPE LECTIN DOMAIN FAMILY 9 MEMBER A endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;import into cell#GO:0098657;establishment of localization#GO:0051234;localization#GO:0051179;receptor-mediated endocytosis#GO:0006898;transport#GO:0006810 cellular anatomical structure#GO:0110165;cell surface#GO:0009986 HUMAN|HGNC=743|UniProtKB=P07307 P07307 ASGR2 PTHR22802:SF433 C-TYPE LECTIN SUPERFAMILY MEMBER ASIALOGLYCOPROTEIN RECEPTOR 2 binding#GO:0005488;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187 immune system process#GO:0002376;immune response#GO:0006955;response to stimulus#GO:0050896 membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell surface#GO:0009986;plasma membrane#GO:0005886 membrane traffic protein#PC00150 HUMAN|HGNC=19611|UniProtKB=Q8NH10 Q8NH10 OR8U1 PTHR48018:SF91 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 8U1-RELATED molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;sensory perception of smell#GO:0007608;response to stimulus#GO:0050896;signaling#GO:0023052;G protein-coupled receptor signaling pathway#GO:0007186;nervous system process#GO:0050877;sensory perception#GO:0007600;cell communication#GO:0007154;cellular process#GO:0009987;signal transduction#GO:0007165;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=27120|UniProtKB=Q6ZPD9 Q6ZPD9 DPY19L3 PTHR31488:SF4 DPY-19-LIKE 1, LIKE (H. SAPIENS) PROTEIN C-MANNOSYL-TRANSFERASE DPY19L3 glycosyltransferase activity#GO:0016757;mannosyltransferase activity#GO:0000030;catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758 organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783 HUMAN|HGNC=6922|UniProtKB=P11226 P11226 MBL2 PTHR24024:SF34 PULMONARY SURFACTANT-ASSOCIATED PROTEIN A MANNOSE-BINDING PROTEIN C signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;pattern recognition receptor activity#GO:0038187 regulation of immune response#GO:0050776;response to external biotic stimulus#GO:0043207;homeostatic process#GO:0042592;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;response to external stimulus#GO:0009605;multicellular organismal-level homeostasis#GO:0048871;defense response#GO:0006952;innate immune response#GO:0045087;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;biological regulation#GO:0065007;response to other organism#GO:0051707;positive regulation of endocytosis#GO:0045807;positive regulation of response to stimulus#GO:0048584;multicellular organismal process#GO:0032501;immune response#GO:0006955;positive regulation of cellular process#GO:0048522;complement activation#GO:0006956;positive regulation of cellular component organization#GO:0051130;immune system process#GO:0002376;biological process involved in interspecies interaction between organisms#GO:0044419;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;regulation of localization#GO:0032879;regulation of transport#GO:0051049;regulation of endocytosis#GO:0030100;immune effector process#GO:0002252;chemical homeostasis#GO:0048878;humoral immune response#GO:0006959;defense response to other organism#GO:0098542;activation of immune response#GO:0002253;positive regulation of transport#GO:0051050;defense response to symbiont#GO:0140546;positive regulation of biological process#GO:0048518;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;positive regulation of immune system process#GO:0002684 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 structural protein#PC00211;surfactant#PC00212 HUMAN|HGNC=6772|UniProtKB=O43541 O43541 SMAD6 PTHR13703:SF28 SMAD SMAD FAMILY MEMBER 6 binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;transcription regulatory region nucleic acid binding#GO:0001067;protein binding#GO:0005515;molecular function inhibitor activity#GO:0140678;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;molecular function regulator activity#GO:0098772 regulation of macromolecule metabolic process#GO:0060255;response to growth factor#GO:0070848;regulation of cellular process#GO:0050794;BMP signaling pathway#GO:0030509;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;regulation of DNA-templated transcription#GO:0006355;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;intracellular signal transduction#GO:0035556;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;developmental process#GO:0032502;response to BMP#GO:0071772;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;cellular response to endogenous stimulus#GO:0071495;cell differentiation#GO:0030154;signaling#GO:0023052;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;cellular response to growth factor stimulus#GO:0071363;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;intracellular signaling cassette#GO:0141124;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to BMP stimulus#GO:0071773;cell surface receptor signaling pathway#GO:0007166 membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 TGF-beta signaling pathway#P00052>I-SMAD#G01548;TGF-beta signaling pathway#P00052>I-Smads#P01289 HUMAN|HGNC=30316|UniProtKB=Q96R05 Q96R05 RBP7 PTHR11955:SF97 FATTY ACID BINDING PROTEIN RETINOID-BINDING PROTEIN 7 lipid binding#GO:0008289;fatty acid binding#GO:0005504;organic acid binding#GO:0043177;ion binding#GO:0043167;small molecule binding#GO:0036094;carboxylic acid binding#GO:0031406;anion binding#GO:0043168;binding#GO:0005488 macromolecule localization#GO:0033036;lipid transport#GO:0006869;lipid localization#GO:0010876;transport#GO:0006810;organic acid transport#GO:0015849;carboxylic acid transport#GO:0046942;establishment of localization#GO:0051234;fatty acid transport#GO:0015908;localization#GO:0051179;monocarboxylic acid transport#GO:0015718 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 transfer/carrier protein#PC00219 HUMAN|HGNC=20761|UniProtKB=Q68DK2 Q68DK2 ZFYVE26 PTHR46591:SF1 ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 26 ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 26 lipid binding#GO:0008289;phosphatidylinositol-3-phosphate binding#GO:0032266;phosphatidylinositol phosphate binding#GO:1901981;binding#GO:0005488;phospholipid binding#GO:0005543 regulation of biological process#GO:0050789;regulation of cell division#GO:0051302;regulation of cytokinesis#GO:0032465;regulation of cell cycle#GO:0051726;regulation of cell cycle process#GO:0010564;biological regulation#GO:0065007;regulation of cellular process#GO:0050794 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;centrosome#GO:0005813;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;midbody#GO:0030496;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=14151|UniProtKB=Q9UJH8 Q9UJH8 METRN PTHR28593:SF2 METEORIN-LIKE PROTEIN METEORIN hormone activity#GO:0005179;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545 positive regulation of cellular process#GO:0048522;regulation of cell development#GO:0060284;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;glial cell differentiation#GO:0010001;positive regulation of developmental process#GO:0051094;developmental process#GO:0032502;regulation of cell differentiation#GO:0045595;regulation of cell projection organization#GO:0031344;neurogenesis#GO:0022008;regulation of plasma membrane bounded cell projection organization#GO:0120035;cellular developmental process#GO:0048869;regulation of neurogenesis#GO:0050767;regulation of developmental process#GO:0050793;positive regulation of neurogenesis#GO:0050769;regulation of cellular process#GO:0050794;positive regulation of cell projection organization#GO:0031346;system development#GO:0048731;regulation of nervous system development#GO:0051960;anatomical structure development#GO:0048856;positive regulation of biological process#GO:0048518;regulation of neuron projection development#GO:0010975;cellular process#GO:0009987;nervous system development#GO:0007399;regulation of multicellular organismal process#GO:0051239;positive regulation of cell development#GO:0010720;positive regulation of cell differentiation#GO:0045597;gliogenesis#GO:0042063;regulation of axonogenesis#GO:0050770;multicellular organism development#GO:0007275;regulation of anatomical structure morphogenesis#GO:0022603;regulation of biological process#GO:0050789;regulation of multicellular organismal development#GO:2000026;positive regulation of multicellular organismal process#GO:0051240;positive regulation of nervous system development#GO:0051962;cell differentiation#GO:0030154;regulation of cellular component organization#GO:0051128;positive regulation of cellular component organization#GO:0051130;animal gross anatomical part developmental process#GO:0160108;positive regulation of axonogenesis#GO:0050772 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=1040|UniProtKB=Q12934 Q12934 BFSP1 PTHR14069:SF0 FILENSIN FILENSIN structural molecule activity#GO:0005198 epithelial cell differentiation#GO:0030855;tissue development#GO:0009888;multicellular organismal process#GO:0032501;epithelium development#GO:0060429;cellular process#GO:0009987;sensory system development#GO:0048880;animal organ development#GO:0048513;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;developmental process#GO:0032502;lens development in camera-type eye#GO:0002088;sensory organ development#GO:0007423;cell development#GO:0048468;visual system development#GO:0150063;cell differentiation#GO:0030154;eye development#GO:0001654;system development#GO:0048731;anatomical structure development#GO:0048856;animal gross anatomical part developmental process#GO:0160108;camera-type eye development#GO:0043010 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;intermediate filament#GO:0005882;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737 HUMAN|HGNC=11208|UniProtKB=Q02447 Q02447 SP3 PTHR23235:SF3 KRUEPPEL-LIKE TRANSCRIPTION FACTOR TRANSCRIPTION FACTOR SP3 binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 C2H2 zinc finger transcription factor#PC00248 CCKR signaling map#P06959>SP3#P07041 HUMAN|HGNC=16764|UniProtKB=Q15916 Q15916 ZBTB6 PTHR24399:SF36 ZINC FINGER AND BTB DOMAIN-CONTAINING ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 6 transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription repressor activity#GO:0001217;sequence-specific DNA binding#GO:0043565 regulation of multicellular organismal process#GO:0051239;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cytokine production#GO:0001817;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;negative regulation of metabolic process#GO:0009892;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233 C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218 HUMAN|HGNC=1396|UniProtKB=Q9P0X4 Q9P0X4 CACNA1I PTHR10037:SF209 VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1I calcium channel activity#GO:0005262;sodium channel activity#GO:0005272;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;sodium ion transmembrane transporter activity#GO:0015081;monoatomic cation channel activity#GO:0005261;channel activity#GO:0015267;voltage-gated calcium channel activity#GO:0005245;transporter activity#GO:0005215;voltage-gated sodium channel activity#GO:0005248;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832 regulation of membrane potential#GO:0042391;calcium ion transmembrane import into cytosol#GO:0097553;calcium ion transport#GO:0006816;regulation of localization#GO:0032879;regulation of transport#GO:0051049;transmission of nerve impulse#GO:0019226;monoatomic cation transmembrane transport#GO:0098655;cellular process#GO:0009987;positive regulation of transport#GO:0051050;positive regulation of secretion by cell#GO:1903532;positive regulation of biological process#GO:0048518;transmembrane transport#GO:0055085;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;regulation of secretion by cell#GO:1903530;positive regulation of cytosolic calcium ion concentration#GO:0007204;nervous system process#GO:0050877;positive regulation of secretion#GO:0051047;calcium ion transmembrane transport#GO:0070588;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;action potential#GO:0001508;establishment of localization#GO:0051234;system process#GO:0003008;transport#GO:0006810;multicellular organismal process#GO:0032501;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;positive regulation of cellular process#GO:0048522;cell communication#GO:0007154;localization#GO:0051179;monoatomic cation transport#GO:0006812;regulation of secretion#GO:0051046;regulation of exocytosis#GO:0017157;regulation of cellular process#GO:0050794;metal ion transport#GO:0030001;membrane depolarization#GO:0051899;calcium ion import#GO:0070509 transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;sodium channel complex#GO:0034706;cation channel complex#GO:0034703;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane#GO:0005886;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;membrane protein complex#GO:0098796;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797 voltage-gated ion channel#PC00241 HUMAN|HGNC=30710|UniProtKB=Q96KC9 Q96KC9 CABS1 PTHR22810:SF1 TESTIS DEVELOPMENT PROTEIN NYD-SP26 CALCIUM-BINDING AND SPERMATID-SPECIFIC PROTEIN 1 calcium ion binding#GO:0005509;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;cation binding#GO:0043169;metal ion binding#GO:0046872 cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;flagellated sperm motility#GO:0030317;microtubule-based process#GO:0007017;cilium-dependent cell motility#GO:0060285;sperm motility#GO:0097722;cellular process#GO:0009987;cilium movement involved in cell motility#GO:0060294;reproductive process#GO:0022414;microtubule-based movement#GO:0007018;cell motility#GO:0048870 secretory vesicle#GO:0099503;cytoplasm#GO:0005737;sperm flagellum#GO:0036126;endomembrane system#GO:0012505;vesicle#GO:0031982;sperm principal piece#GO:0097228;intracellular vesicle#GO:0097708;cell projection#GO:0042995;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;motile cilium#GO:0031514;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;cilium#GO:0005929;9+2 motile cilium#GO:0097729;acrosomal vesicle#GO:0001669;membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410 HUMAN|HGNC=23994|UniProtKB=Q8IV48 Q8IV48 ERI1 PTHR23044:SF77 3'-5' EXONUCLEASE ERI1-RELATED 3'-5' EXORIBONUCLEASE 1 hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;RNA nuclease activity#GO:0004540;3'-5' exonuclease activity#GO:0008408;catalytic activity, acting on RNA#GO:0140098;3'-5'-RNA exonuclease activity#GO:0000175;exonuclease activity#GO:0004527;nuclease activity#GO:0004518;hydrolase activity#GO:0016787 regulation of chromatin organization#GO:1902275;rRNA processing#GO:0006364;positive regulation of biosynthetic process#GO:0009891;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;negative regulation of cellular component organization#GO:0051129;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;rRNA metabolic process#GO:0016072;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;positive regulation of gene expression#GO:0010628;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;RNA metabolic process#GO:0016070;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of biological process#GO:0050789;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;negative regulation of biological process#GO:0048519;ribonucleoprotein complex biogenesis#GO:0022613;maturation of 5.8S rRNA#GO:0000460;regulation of cellular component organization#GO:0051128;regulation of gene silencing by regulatory ncRNA#GO:0060966;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;RNA 3'-end processing#GO:0031123;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;cellular component biogenesis#GO:0044085;RNA processing#GO:0006396;gene expression#GO:0010467;positive regulation of macromolecule metabolic process#GO:0010604 nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232 exoribonuclease#PC00099 HUMAN|HGNC=1808|UniProtKB=O14627 O14627 CDX4 PTHR24332:SF15 HOMEOBOX PROTEIN CDX HOMEOBOX PROTEIN CDX-4 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 embryonic pattern specification#GO:0009880;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;regionalization#GO:0003002;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;tube development#GO:0035295;embryo development#GO:0009790;anterior/posterior pattern specification#GO:0009952;developmental process#GO:0032502;multicellular organism development#GO:0007275;regulation of biosynthetic process#GO:0009889;anterior/posterior axis specification#GO:0009948;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;animal gross anatomical part developmental process#GO:0160108;pattern specification process#GO:0007389;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=7716|UniProtKB=P49821 P49821 NDUFV1 PTHR11780:SF10 NADH-UBIQUINONE OXIDOREDUCTASE FLAVOPROTEIN 1 NDUFV1 NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 1, MITOCHONDRIAL electron transport chain#GO:0022900;respiratory electron transport chain#GO:0022904;cellular process#GO:0009987;mitochondrial ATP synthesis coupled electron transport#GO:0042775;aerobic electron transport chain#GO:0019646;metabolic process#GO:0008152;mitochondrial electron transport, NADH to ubiquinone#GO:0006120;generation of precursor metabolites and energy#GO:0006091;cellular respiration#GO:0045333;energy derivation by oxidation of organic compounds#GO:0015980;oxidative phosphorylation#GO:0006119;ATP synthesis coupled electron transport#GO:0042773;aerobic respiration#GO:0009060 transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;respiratory chain complex I#GO:0045271;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;oxidoreductase complex#GO:1990204;membrane#GO:0016020;membrane protein complex#GO:0098796;respiratory chain complex#GO:0098803 oxidoreductase#PC00176 HUMAN|HGNC=26654|UniProtKB=Q8N715 Q8N715 CCDC185 PTHR33663:SF3 COILED-COIL DOMAIN-CONTAINING PROTEIN 177 COILED-COIL DOMAIN-CONTAINING PROTEIN 185 HUMAN|HGNC=16885|UniProtKB=Q9BRG2 Q9BRG2 SH2D3A PTHR14247:SF11 BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3 HOMOLOG-LIKE PROTEIN SH2 DOMAIN-CONTAINING PROTEIN 3A HUMAN|HGNC=16398|UniProtKB=Q9BXW6 Q9BXW6 OSBPL1A PTHR10972:SF53 OXYSTEROL-BINDING PROTEIN-RELATED OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 1 alcohol binding#GO:0043178;steroid binding#GO:0005496;lipid binding#GO:0008289;cholesterol binding#GO:0015485;binding#GO:0005488;small molecule binding#GO:0036094;sterol binding#GO:0032934 cytosol#GO:0005829;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 transfer/carrier protein#PC00219 HUMAN|HGNC=21605|UniProtKB=Q14151 Q14151 SAFB2 PTHR15683:SF4 SCAFFOLD ATTACHMENT FACTOR B-RELATED SCAFFOLD ATTACHMENT FACTOR B2 regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;regulation of intracellular signal transduction#GO:1902531;regulation of biological process#GO:0050789;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=20093|UniProtKB=Q8N142 Q8N142 ADSS1 PTHR11846:SF2 ADENYLOSUCCINATE SYNTHETASE ADENYLOSUCCINATE SYNTHETASE ISOZYME 1 ligase activity#GO:0016874;catalytic activity#GO:0003824;ligase activity, forming carbon-nitrogen bonds#GO:0016879 ribose phosphate biosynthetic process#GO:0046390;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing compound biosynthetic process#GO:0034654;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;purine nucleoside monophosphate metabolic process#GO:0009126;phosphorus metabolic process#GO:0006793;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;small molecule metabolic process#GO:0044281;purine ribonucleoside monophosphate metabolic process#GO:0009167;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;nucleoside monophosphate biosynthetic process#GO:0009124;ribonucleotide metabolic process#GO:0009259;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide biosynthetic process#GO:0009165;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;carbohydrate derivative metabolic process#GO:1901135;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;nucleoside phosphate biosynthetic process#GO:1901293;primary metabolic process#GO:0044238;IMP metabolic process#GO:0046040;nucleoside monophosphate metabolic process#GO:0009123;nucleoside phosphate metabolic process#GO:0006753;organophosphate biosynthetic process#GO:0090407 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;ligase#PC00142 De novo purine biosynthesis#P02738>Adenylosuccinate synthase#P02890;Wnt signaling pathway#P00057>NFAT Target Genes#G01559 HUMAN|HGNC=13049|UniProtKB=Q9Y2P7 Q9Y2P7 ZNF256 PTHR24377:SF685 IP01015P-RELATED ZINC FINGER PROTEIN 256 DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=24448|UniProtKB=Q9NRP0 Q9NRP0 OSTC PTHR13160:SF9 OLIGOSACCHARYLTRANSFERASE COMPLEX SUBUNIT OSTC OLIGOSACCHARYLTRANSFERASE COMPLEX SUBUNIT OSTC molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 protein N-linked glycosylation#GO:0006487;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;biosynthetic process#GO:0009058;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170 oligosaccharyltransferase complex#GO:0008250;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;membrane protein complex#GO:0098796;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;endoplasmic reticulum subcompartment#GO:0098827;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;membrane#GO:0016020;endoplasmic reticulum protein-containing complex#GO:0140534;organelle membrane#GO:0031090;transferase complex#GO:1990234;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 transferase#PC00220;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=30683|UniProtKB=Q9BX59 Q9BX59 TAPBPL PTHR23411:SF18 TAPASIN TAPASIN-RELATED PROTEIN binding#GO:0005488;protein-containing complex binding#GO:0044877 immune system process#GO:0002376;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;antigen processing and presentation#GO:0019882;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;cellular component assembly#GO:0022607 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;membrane protein complex#GO:0098796;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;cytoplasm#GO:0005737;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;membrane#GO:0016020;organelle membrane#GO:0031090;endoplasmic reticulum protein-containing complex#GO:0140534;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=1858|UniProtKB=Q7Z7A1 Q7Z7A1 CNTRL PTHR34491:SF173 A-TYPE INCLUSION PROTEIN, PUTATIVE-RELATED CENTRIOLIN microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 HUMAN|HGNC=30206|UniProtKB=Q5M7Z0 Q5M7Z0 RNFT1 PTHR15860:SF1 UNCHARACTERIZED RING FINGER-CONTAINING PROTEIN E3 UBIQUITIN-PROTEIN LIGASE RNFT1 ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824 positive regulation of protein metabolic process#GO:0051247;regulation of cellular response to stress#GO:0080135;positive regulation of protein catabolic process#GO:0045732;regulation of protein catabolic process#GO:0042176;positive regulation of metabolic process#GO:0009893;regulation of biological process#GO:0050789;regulation of response to endoplasmic reticulum stress#GO:1905897;positive regulation of proteasomal protein catabolic process#GO:1901800;regulation of ERAD pathway#GO:1904292;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of response to stimulus#GO:0048583;regulation of response to stress#GO:0080134;regulation of catabolic process#GO:0009894;positive regulation of catabolic process#GO:0009896;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;positive regulation of macromolecule metabolic process#GO:0010604;regulation of proteasomal protein catabolic process#GO:0061136;positive regulation of response to stimulus#GO:0048584 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=10869|UniProtKB=Q92185 Q92185 ST8SIA1 PTHR11987:SF3 ALPHA-2,8-SIALYLTRANSFERASE ALPHA-N-ACETYLNEURAMINIDE ALPHA-2,8-SIALYLTRANSFERASE sialyltransferase activity#GO:0008373;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;transferase activity#GO:0016740 glycoprotein biosynthetic process#GO:0009101;protein N-linked glycosylation#GO:0006487;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;carbohydrate metabolic process#GO:0005975;biosynthetic process#GO:0009058;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;oligosaccharide metabolic process#GO:0009311 metabolite interconversion enzyme#PC00262;transferase#PC00220 HUMAN|HGNC=6107|UniProtKB=P52945 P52945 PDX1 PTHR45664:SF12 PROTEIN ZERKNUELLT 1-RELATED PANCREAS_DUODENUM HOMEOBOX PROTEIN 1 DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 developmental process#GO:0032502;regulation of gene expression#GO:0010468;multicellular organism development#GO:0007275;animal organ development#GO:0048513;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;epithelium development#GO:0060429;multicellular organismal process#GO:0032501;tissue development#GO:0009888;epithelial cell differentiation#GO:0030855;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of biological process#GO:0050789;pancreas development#GO:0031016;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 homeodomain transcription factor#PC00119 HUMAN|HGNC=33821|UniProtKB=Q6NVU6 Q6NVU6 UFSP1 PTHR48153:SF3 UFM1-SPECIFIC PROTEASE 2 UFM1-SPECIFIC PROTEASE 1 ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234 HUMAN|HGNC=7910|UniProtKB=P06748 P06748 NPM1 PTHR22747:SF28 NUCLEOPLASMIN NUCLEOPHOSMIN protein binding#GO:0005515;RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;chromatin binding#GO:0003682;histone binding#GO:0042393 ribosomal small subunit export from nucleus#GO:0000056;nucleocytoplasmic transport#GO:0006913;ribosome localization#GO:0033750;regulation of microtubule-based process#GO:0032886;organelle localization#GO:0051640;regulation of RNA metabolic process#GO:0051252;nuclear export#GO:0051168;nuclear transport#GO:0051169;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;localization#GO:0051179;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;transport#GO:0006810;ribosomal subunit export from nucleus#GO:0000054;intracellular transport#GO:0046907;regulation of gene expression#GO:0010468;establishment of localization#GO:0051234;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;chromatin organization#GO:0006325;positive regulation of RNA biosynthetic process#GO:1902680;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;ribosome biogenesis#GO:0042254;ribosomal large subunit biogenesis#GO:0042273;cellular localization#GO:0051641;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of biological process#GO:0050789;ribosomal large subunit export from nucleus#GO:0000055;cellular component organization#GO:0016043;chromatin remodeling#GO:0006338;ribonucleoprotein complex biogenesis#GO:0022613;regulation of cell cycle#GO:0051726;establishment of organelle localization#GO:0051656;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular component organization#GO:0051128;ribosomal small subunit biogenesis#GO:0042274;positive regulation of transcription by RNA polymerase II#GO:0045944;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;positive regulation of biological process#GO:0048518;cellular component biogenesis#GO:0044085;regulation of cell cycle process#GO:0010564;positive regulation of macromolecule metabolic process#GO:0010604 organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;microtubule cytoskeleton#GO:0015630;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;centrosome#GO:0005813;membraneless organelle#GO:0043228 chaperone#PC00072 HUMAN|HGNC=8181|UniProtKB=Q8NGR6 Q8NGR6 OR1B1 PTHR48001:SF125 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 1B1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=3270|UniProtKB=O75822 O75822 EIF3J PTHR21681:SF0 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J translation factor activity#GO:0180051;translation initiation factor activity#GO:0003743 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of translational initiation#GO:0006446;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;eukaryotic translation initiation factor 3 complex#GO:0005852 translation initiation factor#PC00224 HUMAN|HGNC=28177|UniProtKB=Q567V2 Q567V2 MPV17L2 PTHR11266:SF8 PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17 MPV17-LIKE PROTEIN 2 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 transporter#PC00227 HUMAN|HGNC=26673|UniProtKB=Q8IWY8 Q8IWY8 ZSCAN29 PTHR23226:SF184 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 29 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987 regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=6458|UniProtKB=Q14533 Q14533 KRT81 PTHR45616:SF64 GATA-TYPE DOMAIN-CONTAINING PROTEIN KERATIN, TYPE II CUTICULAR HB1 structural molecule activity#GO:0005198 developmental process#GO:0032502;epidermis development#GO:0008544;animal organ development#GO:0048513;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;skin development#GO:0043588;multicellular organismal process#GO:0032501;epithelial cell differentiation#GO:0030855;epidermal cell differentiation#GO:0009913;tissue development#GO:0009888;epithelium development#GO:0060429;intermediate filament organization#GO:0045109;animal gross anatomical part developmental process#GO:0160108;keratinocyte differentiation#GO:0030216;intermediate filament-based process#GO:0045103;supramolecular fiber organization#GO:0097435;anatomical structure development#GO:0048856;cellular component organization#GO:0016043;cell differentiation#GO:0030154;intermediate filament cytoskeleton organization#GO:0045104 cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;organelle#GO:0043226;supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;intracellular anatomical structure#GO:0005622;intermediate filament#GO:0005882;supramolecular fiber#GO:0099512;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 HUMAN|HGNC=25732|UniProtKB=Q9H0H3 Q9H0H3 KLHL25 PTHR24410:SF10 HL07962P-RELATED KELCH-LIKE PROTEIN 25 enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;protein metabolic process#GO:0019538;positive regulation of metabolic process#GO:0009893;regulation of lipid metabolic process#GO:0019216;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;modification-dependent protein catabolic process#GO:0019941 Cul3-RING ubiquitin ligase complex#GO:0031463;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535;catalytic complex#GO:1902494;transferase complex#GO:1990234 defense/immunity protein#PC00090 HUMAN|Ensembl=ENSG00000288432.1|UniProtKB=A0AAG2TVH8 A0AAG2TVH8 PTHR12138:SF167 PRIMATE-EXPANDED PROTEIN FAMILY SECRETED PROTEIN HUMAN|HGNC=13145|UniProtKB=P51815 P51815 ZNF75D PTHR23226:SF272 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER PROTEIN 75D sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=21533|UniProtKB=Q9Y343 Q9Y343 SNX24 PTHR15813:SF10 SORTING NEXIN-22 AND 24 SORTING NEXIN-24 binding#GO:0005488;phospholipid binding#GO:0005543;lipid binding#GO:0008289;phosphatidylinositol phosphate binding#GO:1901981 scaffold/adaptor protein#PC00226 HUMAN|HGNC=11556|UniProtKB=P17542 P17542 TAL1 PTHR13864:SF16 T-CELL ACUTE LYMPHOCYTIC LEUKEMIA/STEM CELL LEUKEMIA-RELATED T-CELL ACUTE LYMPHOCYTIC LEUKEMIA PROTEIN 1 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=30324|UniProtKB=Q969G6 Q969G6 RFK PTHR22749:SF14 RIBOFLAVIN KINASE/FMN ADENYLYLTRANSFERASE RIBOFLAVIN KINASE phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 nucleotide biosynthetic process#GO:0009165;nucleotide metabolic process#GO:0009117;organophosphate biosynthetic process#GO:0090407;nucleoside monophosphate biosynthetic process#GO:0009124;ribonucleotide metabolic process#GO:0009259;nucleoside monophosphate metabolic process#GO:0009123;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;nucleobase-containing small molecule metabolic process#GO:0055086;flavin-containing compound metabolic process#GO:0042726;nucleoside phosphate biosynthetic process#GO:1901293;carbohydrate derivative biosynthetic process#GO:1901137;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;carbohydrate derivative metabolic process#GO:1901135;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;ribose phosphate biosynthetic process#GO:0046390 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 Flavin biosynthesis#P02741>FAD synthetase#P02936;Flavin biosynthesis#P02741>Riboflavin kinase#P02934 HUMAN|HGNC=1611|UniProtKB=Q9NPB9 Q9NPB9 ACKR4 PTHR10489:SF733 CELL ADHESION MOLECULE ATYPICAL CHEMOKINE RECEPTOR 4 molecular transducer activity#GO:0060089;protein binding#GO:0005515;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888;immune receptor activity#GO:0140375;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;cytokine binding#GO:0019955;cytokine receptor activity#GO:0004896 taxis#GO:0042330;response to chemical#GO:0042221;cell migration#GO:0016477;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124;immune response#GO:0006955;signal transduction#GO:0007165;cellular process#GO:0009987;response to external stimulus#GO:0009605;calcium-mediated signaling#GO:0019722;response to stimulus#GO:0050896;cell motility#GO:0048870;regulation of cellular process#GO:0050794;signaling#GO:0023052;locomotion#GO:0040011;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;cell chemotaxis#GO:0060326;intracellular signal transduction#GO:0035556;regulation of biological quality#GO:0065008;cellular response to chemical stimulus#GO:0070887;immune system process#GO:0002376;positive regulation of cytosolic calcium ion concentration#GO:0007204;chemotaxis#GO:0006935 membrane#GO:0016020;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell surface#GO:0009986;plasma membrane#GO:0005886 cell adhesion molecule#PC00069 HUMAN|HGNC=9878|UniProtKB=O95267 O95267 RASGRP1 PTHR23113:SF174 GUANINE NUCLEOTIDE EXCHANGE FACTOR RAS GUANYL-RELEASING PROTEIN 1 molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;guanyl-nucleotide exchange factor activity#GO:0005085 positive regulation of response to external stimulus#GO:0032103;B cell activation#GO:0042113;lymphocyte activation#GO:0046649;regulation of response to external stimulus#GO:0032101;intracellular signaling cassette#GO:0141124;positive regulation of immune system process#GO:0002684;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;immune system process#GO:0002376;regulation of lymphocyte mediated immunity#GO:0002706;regulation of cell killing#GO:0031341;response to stimulus#GO:0050896;signaling#GO:0023052;T cell activation#GO:0042110;regulation of biological process#GO:0050789;regulation of innate immune response#GO:0045088;positive regulation of response to biotic stimulus#GO:0002833;positive regulation of leukocyte mediated immunity#GO:0002705;regulation of response to stress#GO:0080134;positive regulation of immune response#GO:0050778;positive regulation of defense response#GO:0031349;regulation of response to stimulus#GO:0048583;positive regulation of response to stimulus#GO:0048584;regulation of natural killer cell mediated cytotoxicity#GO:0042269;multicellular organismal process#GO:0032501;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;positive regulation of immune effector process#GO:0002699;positive regulation of natural killer cell mediated cytotoxicity#GO:0045954;positive regulation of cellular process#GO:0048522;positive regulation of innate immune response#GO:0045089;positive regulation of lymphocyte mediated immunity#GO:0002708;cell communication#GO:0007154;regulation of immune effector process#GO:0002697;regulation of leukocyte mediated cytotoxicity#GO:0001910;intracellular signal transduction#GO:0035556;Ras protein signal transduction#GO:0007265;regulation of immune response#GO:0050776;regulation of defense response#GO:0031347;cell activation#GO:0001775;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of response to biotic stimulus#GO:0002831;positive regulation of natural killer cell mediated immunity#GO:0002717;leukocyte activation#GO:0045321;regulation of leukocyte mediated immunity#GO:0002703;regulation of natural killer cell mediated immunity#GO:0002715;cellular response to stimulus#GO:0051716 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 guanyl-nucleotide exchange factor#PC00113 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>CalDAG-GEF#P00736 HUMAN|HGNC=13890|UniProtKB=Q96J02 Q96J02 ITCH PTHR11254:SF66 HECT DOMAIN UBIQUITIN-PROTEIN LIGASE E3 UBIQUITIN-PROTEIN LIGASE ITCHY HOMOLOG ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740 ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 Ubiquitin proteasome pathway#P00060>E3#P01490 HUMAN|HGNC=32790|UniProtKB=Q9NRX1 Q9NRX1 PNO1 PTHR12826:SF13 RIBONUCLEASE Y RNA-BINDING PROTEIN PNO1 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 endoribonuclease#PC00094 HUMAN|HGNC=1099|UniProtKB=Q7Z569 Q7Z569 BRAP PTHR24007:SF7 BRCA1-ASSOCIATED PROTEIN BRCA1-ASSOCIATED PROTEIN ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein modification process#GO:0036211;primary metabolic process#GO:0044238;protein modification by small protein conjugation#GO:0032446;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;Ras protein signal transduction#GO:0007265;protein modification by small protein conjugation or removal#GO:0070647;cell communication#GO:0007154;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;intracellular signal transduction#GO:0035556;signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;protein ubiquitination#GO:0016567;intracellular signaling cassette#GO:0141124;post-translational protein modification#GO:0043687;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=13395|UniProtKB=O96009 O96009 NAPSA PTHR47966:SF83 BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED NAPSIN-A catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity#GO:0003824;aspartic-type endopeptidase activity#GO:0004190 cellular process#GO:0009987;metabolic process#GO:0008152;proteolysis#GO:0006508;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 intracellular organelle#GO:0043229;extracellular region#GO:0005576;lytic vacuole#GO:0000323;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;lysosome#GO:0005764;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vacuole#GO:0005773;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 protease#PC00190;aspartic protease#PC00053 HUMAN|HGNC=18475|UniProtKB=Q9Y397 Q9Y397 ZDHHC9 PTHR22883:SF71 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE ZDHHC9 catalytic activity, acting on a protein#GO:0140096;palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746 protein targeting to membrane#GO:0006612;localization within membrane#GO:0051668;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;establishment of protein localization to membrane#GO:0090150;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein targeting#GO:0006605 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HUMAN|HGNC=11804|UniProtKB=Q01085 Q01085 TIAL1 PTHR10352:SF11 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G NUCLEOLYSIN TIAR regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;regulation of alternative mRNA splicing, via spliceosome#GO:0000381;regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of mRNA processing#GO:0050684;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of mRNA metabolic process#GO:1903311 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 HUMAN|HGNC=28382|UniProtKB=Q8NEP9 Q8NEP9 ZNF555 PTHR24381:SF446 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 555 DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=12735|UniProtKB=O00401 O00401 WASL PTHR13037:SF23 FORMIN ACTIN NUCLEATION-PROMOTING FACTOR WASL binding#GO:0005488;microtubule binding#GO:0008017;tubulin binding#GO:0015631;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515 cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;cellular component assembly#GO:0022607;cellular process#GO:0009987;actin filament bundle organization#GO:0061572;actin filament bundle assembly#GO:0051017;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029 endomembrane system#GO:0012505;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630;membrane#GO:0016020;nucleus#GO:0005634;membraneless organelle#GO:0043228;organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;cytoskeleton#GO:0005856;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229 Huntington disease#P00029>N-Wasp#P00769;Cytoskeletal regulation by Rho GTPase#P00016>N-WASP#P00525 HUMAN|HGNC=13107|UniProtKB=P51814 P51814 ZNF41 PTHR24377:SF1056 IP01015P-RELATED ZINC FINGER PROTEIN 41 transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=11597|UniProtKB=Q13207 Q13207 TBX2 PTHR11267:SF82 T-BOX PROTEIN-RELATED T-BOX TRANSCRIPTION FACTOR TBX2 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of RNA metabolic process#GO:0051252;cell fate commitment#GO:0045165;regulation of DNA-templated transcription#GO:0006355;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;cell fate specification#GO:0001708;developmental process#GO:0032502;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869 intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229 immunoglobulin fold transcription factor#PC00251;Rel homology transcription factor#PC00252 HUMAN|HGNC=9782|UniProtKB=P61018 P61018 RAB4B PTHR47979:SF17 DRAB11-RELATED RAS-RELATED PROTEIN RAB-4B purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;guanyl nucleotide binding#GO:0019001;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;GTPase activity#GO:0003924;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094 transport#GO:0006810;regulation of endocytosis#GO:0030100;establishment of localization#GO:0051234;localization#GO:0051179;regulation of transport#GO:0051049;regulation of localization#GO:0032879;cellular process#GO:0009987;regulation of biological process#GO:0050789;vesicle-mediated transport#GO:0016192;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;secretory vesicle#GO:0099503;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;recycling endosome#GO:0055037;endosome#GO:0005768;intracellular organelle#GO:0043229 G-protein#PC00020;small GTPase#PC00208 HUMAN|HGNC=25177|UniProtKB=Q96CP7 Q96CP7 TLCD1 PTHR13439:SF5 CT120 PROTEIN TLC DOMAIN-CONTAINING PROTEIN 1 lipid homeostasis#GO:0055088;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;membrane assembly#GO:0071709;cellular component assembly#GO:0022607;membrane organization#GO:0061024;endomembrane system organization#GO:0010256;homeostatic process#GO:0042592;biological regulation#GO:0065007;chemical homeostasis#GO:0048878;plasma membrane organization#GO:0007009;cellular component organization or biogenesis#GO:0071840;regulation of membrane lipid distribution#GO:0097035;regulation of biological quality#GO:0065008 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 metabolite interconversion enzyme#PC00262;transferase#PC00220 HUMAN|HGNC=31969|UniProtKB=Q5MNV8 Q5MNV8 FBXO47 PTHR34098:SF1 F-BOX ONLY PROTEIN 47 F-BOX ONLY PROTEIN 47 HUMAN|HGNC=26730|UniProtKB=Q8N9H9 Q8N9H9 CIROZ PTHR38653:SF1 GENE 572-RELATED CILIATED LEFT-RIGHT ORGANIZER ZP-N DOMAINS-CONTAINING PROTEIN HUMAN|HGNC=19080|UniProtKB=Q9NR34 Q9NR34 MAN1C1 PTHR11742:SF28 MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE IC hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;response to stress#GO:0006950;cellular process#GO:0009987;response to chemical#GO:0042221;proteasomal protein catabolic process#GO:0010498;response to endoplasmic reticulum stress#GO:0034976;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;ERAD pathway#GO:0036503;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;catabolic process#GO:0009056 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 protein modifying enzyme#PC00260 HUMAN|HGNC=10731|UniProtKB=Q9C0C4 Q9C0C4 SEMA4C PTHR11036:SF16 SEMAPHORIN SEMAPHORIN-4C signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515;molecular function activator activity#GO:0140677;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772 neuron projection guidance#GO:0097485;positive regulation of locomotion#GO:0040017;response to external stimulus#GO:0009605;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;developmental process#GO:0032502;regulation of cell migration#GO:0030334;neuron projection morphogenesis#GO:0048812;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;plasma membrane bounded cell projection organization#GO:0120036;multicellular organismal process#GO:0032501;positive regulation of cellular process#GO:0048522;positive regulation of cell migration#GO:0030335;axon development#GO:0061564;axon guidance#GO:0007411;system development#GO:0048731;cell communication#GO:0007154;regulation of cell motility#GO:2000145;anatomical structure development#GO:0048856;chemotaxis#GO:0006935;locomotion#GO:0040011;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;cell projection morphogenesis#GO:0048858;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell surface receptor signaling pathway#GO:0007166;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;taxis#GO:0042330;response to chemical#GO:0042221;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;neuron projection development#GO:0031175;neuron development#GO:0048666;axonogenesis#GO:0007409;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;signaling#GO:0023052;cell development#GO:0048468;cell projection organization#GO:0030030;cell differentiation#GO:0030154;response to stimulus#GO:0050896;cell morphogenesis#GO:0000902;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;positive regulation of cell motility#GO:2000147;cellular component organization#GO:0016043 cell junction#GO:0030054;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;transport vesicle#GO:0030133;endomembrane system#GO:0012505;transport vesicle membrane#GO:0030658;cytoplasmic vesicle membrane#GO:0030659;plasma membrane#GO:0005886;cytoplasm#GO:0005737;vesicle membrane#GO:0012506;secretory vesicle#GO:0099503;membrane#GO:0016020;presynapse#GO:0098793;cell periphery#GO:0071944;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;organelle#GO:0043226;cellular anatomical structure#GO:0110165;synapse#GO:0045202;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;synaptic vesicle membrane#GO:0030672;vesicle#GO:0031982;synaptic vesicle#GO:0008021 membrane-bound signaling molecule#PC00152 HUMAN|HGNC=22408|UniProtKB=Q7Z3C6 Q7Z3C6 ATG9A PTHR13038:SF13 APG9 AUTOPHAGY 9 AUTOPHAGY-RELATED PROTEIN 9A phospholipid scramblase activity#GO:0017128;transporter activity#GO:0005215;molecular carrier activity#GO:0140104;lipid carrier activity#GO:0005319;intramembrane lipid carrier activity#GO:0140303 cellular component assembly#GO:0022607;macroautophagy#GO:0016236;reticulophagy#GO:0061709;macromolecule localization#GO:0033036;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;autophagosome organization#GO:1905037;cellular process#GO:0009987;autophagy#GO:0006914;mitophagy#GO:0000423;cellular component organization or biogenesis#GO:0071840;autophagosome assembly#GO:0000045;intracellular protein localization#GO:0008104;autophagy of mitochondrion#GO:0000422;metabolic process#GO:0008152;catabolic process#GO:0009056;piecemeal microautophagy of the nucleus#GO:0034727;cellular component organization#GO:0016043;localization#GO:0051179;process utilizing autophagic mechanism#GO:0061919;vacuole organization#GO:0007033;organelle assembly#GO:0070925 autophagosome#GO:0005776;phagophore assembly site#GO:0000407;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;vacuole#GO:0005773 HUMAN|HGNC=7859|UniProtKB=P48645 P48645 NMU PTHR15390:SF0 NEUROMEDIN-U NEUROMEDIN-U signaling receptor binding#GO:0005102;binding#GO:0005488;neuropeptide receptor binding#GO:0071855;G protein-coupled receptor binding#GO:0001664;protein binding#GO:0005515 neuropeptide signaling pathway#GO:0007218;regulation of muscle system process#GO:0090257;cellular response to stimulus#GO:0051716;positive regulation of multicellular organismal process#GO:0051240;regulation of biological process#GO:0050789;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of cell communication#GO:0010646;signaling#GO:0023052;modulation of chemical synaptic transmission#GO:0050804;positive regulation of synaptic transmission#GO:0050806;G protein-coupled receptor signaling pathway#GO:0007186;regulation of muscle contraction#GO:0006937;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;cell communication#GO:0007154;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of trans-synaptic signaling#GO:0099177;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;regulation of system process#GO:0044057;regulation of smooth muscle contraction#GO:0006940 cell junction#GO:0030054;axon terminus#GO:0043679;axon#GO:0030424;synapse#GO:0045202;cellular anatomical structure#GO:0110165;distal axon#GO:0150034;plasma membrane bounded cell projection#GO:0120025;terminal bouton#GO:0043195;neuron projection terminus#GO:0044306;cell projection#GO:0042995;presynapse#GO:0098793;neuron projection#GO:0043005 HUMAN|HGNC=30905|UniProtKB=Q49A92 Q49A92 C8orf34 PTHR32000:SF3 SIMILAR TO HYPOTHETICAL PROTEIN SIMILAR TO HUMAN CHROMOSOME 8 OPEN READING FRAME 34 HUMAN|HGNC=19213|UniProtKB=Q96MC5 Q96MC5 BMERB1 PTHR22704:SF1 BMERB DOMAIN-CONTAINING PROTEIN 1-RELATED BMERB DOMAIN-CONTAINING PROTEIN 1 negative regulation of protein-containing complex disassembly#GO:0043242;negative regulation of cytoskeleton organization#GO:0051494;regulation of microtubule-based process#GO:0032886;regulation of cellular process#GO:0050794;regulation of cytoskeleton organization#GO:0051493;negative regulation of supramolecular fiber organization#GO:1902904;regulation of cellular component organization#GO:0051128;negative regulation of organelle organization#GO:0010639;negative regulation of cellular component organization#GO:0051129;negative regulation of biological process#GO:0048519;regulation of organelle organization#GO:0033043;regulation of supramolecular fiber organization#GO:1902903;regulation of biological process#GO:0050789;regulation of protein depolymerization#GO:1901879;regulation of microtubule polymerization or depolymerization#GO:0031110;negative regulation of cellular process#GO:0048523;negative regulation of protein depolymerization#GO:1901880;regulation of microtubule cytoskeleton organization#GO:0070507;biological regulation#GO:0065007;regulation of protein-containing complex disassembly#GO:0043244 microtubule cytoskeleton#GO:0015630;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=4729|UniProtKB=P20671 P20671 H2AC7 PTHR23430:SF56 HISTONE H2A HISTONE H2A TYPE 1-D structural molecule activity#GO:0005198 negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;cellular component organization or biogenesis#GO:0071840;negative regulation of gene expression, epigenetic#GO:0045814;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;epigenetic regulation of gene expression#GO:0040029;chromatin organization#GO:0006325;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;heterochromatin organization#GO:0070828;cellular component assembly#GO:0022607;heterochromatin formation#GO:0031507;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;nucleosome#GO:0000786;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;protein-DNA complex#GO:0032993 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=16707|UniProtKB=Q96T75 Q96T75 DSCR8 PTHR12138:SF163 PRIMATE-EXPANDED PROTEIN FAMILY DOWN SYNDROME CRITICAL REGION PROTEIN 8 HUMAN|HGNC=8260|UniProtKB=O76002 O76002 OR2J2 PTHR26453:SF318 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2J2 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 system process#GO:0003008;sensory perception#GO:0007600;nervous system process#GO:0050877;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;response to chemical#GO:0042221;response to stimulus#GO:0050896;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;detection of chemical stimulus#GO:0009593;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=3436|UniProtKB=Q92889 Q92889 ERCC4 PTHR10150:SF0 DNA REPAIR ENDONUCLEASE XPF DNA REPAIR ENDONUCLEASE XPF endonuclease activity#GO:0004519;catalytic activity, acting on DNA#GO:0140097;hydrolase activity, acting on ester bonds#GO:0016788;DNA nuclease activity#GO:0004536;damaged DNA binding#GO:0003684;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;nuclease activity#GO:0004518;DNA binding#GO:0003677;hydrolase activity#GO:0016787;DNA endonuclease activity#GO:0004520;single-stranded DNA binding#GO:0003697;nucleic acid binding#GO:0003676;binding#GO:0005488 organelle fission#GO:0048285;sexual reproduction#GO:0019953;recombinational repair#GO:0000725;mitotic recombination#GO:0006312;meiosis I cell cycle process#GO:0061982;homologous recombination#GO:0035825;reproductive process#GO:0022414;cellular response to stimulus#GO:0051716;reciprocal homologous recombination#GO:0140527;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cell cycle#GO:0007049;meiotic nuclear division#GO:0140013;macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;DNA repair#GO:0006281;nucleobase-containing compound metabolic process#GO:0006139;interstrand cross-link repair#GO:0036297;resolution of meiotic recombination intermediates#GO:0000712;reciprocal meiotic recombination#GO:0007131;cellular response to stress#GO:0033554;nuclear division#GO:0000280;response to stimulus#GO:0050896;cell cycle process#GO:0022402;double-strand break repair via homologous recombination#GO:0000724;cellular component organization#GO:0016043;meiotic cell cycle process#GO:1903046;meiosis I#GO:0007127;double-strand break repair#GO:0006302;cellular component organization or biogenesis#GO:0071840;DNA recombination#GO:0006310;DNA metabolic process#GO:0006259;meiotic cell cycle#GO:0051321;metabolic process#GO:0008152;nucleotide-excision repair#GO:0006289;cellular process#GO:0009987;response to stress#GO:0006950;organelle organization#GO:0006996 nucleotide-excision repair complex#GO:0000109;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 endodeoxyribonuclease#PC00093;DNA metabolism protein#PC00009 HUMAN|HGNC=16139|UniProtKB=Q9H1F0 Q9H1F0 WFDC10A PTHR19441:SF38 WAP four-disulfide core domain protein WAP FOUR-DISULFIDE CORE DOMAIN PROTEIN 10A molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866;enzyme inhibitor activity#GO:0004857;molecular function inhibitor activity#GO:0140678;serine-type endopeptidase inhibitor activity#GO:0004867;enzyme regulator activity#GO:0030234;peptidase regulator activity#GO:0061134;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414 response to bacterium#GO:0009617;immune system process#GO:0002376;defense response to bacterium#GO:0042742;response to stimulus#GO:0050896;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;antimicrobial humoral response#GO:0019730;humoral immune response#GO:0006959;innate immune response#GO:0045087;antibacterial humoral response#GO:0019731;response to external stimulus#GO:0009605;defense response#GO:0006952;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;defense response to symbiont#GO:0140546;immune response#GO:0006955;defense response to other organism#GO:0098542;response to other organism#GO:0051707 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease inhibitor#PC00191 HUMAN|HGNC=12876|UniProtKB=Q9NY26 Q9NY26 SLC39A1 PTHR11040:SF58 ZINC/IRON TRANSPORTER ZINC TRANSPORTER ZIP1 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;transition metal ion transmembrane transporter activity#GO:0046915;zinc ion transmembrane transporter activity#GO:0005385;monoatomic cation transmembrane transporter activity#GO:0008324;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075 inorganic cation import across plasma membrane#GO:0098659;establishment of localization#GO:0051234;import into cell#GO:0098657;transport#GO:0006810;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;zinc ion transport#GO:0006829;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;zinc ion transmembrane transport#GO:0071577;transition metal ion transport#GO:0000041;metal ion transport#GO:0030001;inorganic ion import across plasma membrane#GO:0099587;import across plasma membrane#GO:0098739 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 secondary carrier transporter#PC00258 HUMAN|HGNC=10541|UniProtKB=Q01826 Q01826 SATB1 PTHR15116:SF14 DNA-BINDING PROTEIN SATB FAMILY MEMBER DNA-BINDING PROTEIN SATB1 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;chromatin remodeling#GO:0006338;cellular component organization#GO:0016043;regulation of biological process#GO:0050789 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;Lambda repressor-like transcription factor#PC00245 HUMAN|HGNC=14929|UniProtKB=Q96EB6 Q96EB6 SIRT1 PTHR11085:SF9 NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-1 deacetylase activity#GO:0019213;histone modifying activity#GO:0140993;acyltransferase activity#GO:0016746;transcription regulator activity#GO:0140110;NAD-dependent protein lysine deacetylase activity#GO:0034979;catalytic activity, acting on a protein#GO:0140096;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transcription coregulator activity#GO:0003712;catalytic activity#GO:0003824;transcription corepressor activity#GO:0003714;histone deacetylase activity#GO:0004407;deacylase activity#GO:0160215;transferase activity#GO:0016740 regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;chromatin organization#GO:0006325;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;DNA damage response#GO:0006974;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;heterochromatin formation#GO:0031507;cellular response to stimulus#GO:0051716;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;cellular component assembly#GO:0022607;heterochromatin organization#GO:0070828;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;response to stress#GO:0006950;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;negative regulation of gene expression, epigenetic#GO:0045814;constitutive heterochromatin formation#GO:0140719;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;response to stimulus#GO:0050896;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;cellular response to stress#GO:0033554 organelle envelope#GO:0031967;chromosome#GO:0005694;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle inner membrane#GO:0019866;nucleus#GO:0005634;chromatin#GO:0000785;membrane#GO:0016020;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;nuclear envelope#GO:0005635;endomembrane system#GO:0012505;nuclear inner membrane#GO:0005637;nuclear membrane#GO:0031965;organelle membrane#GO:0031090;heterochromatin#GO:0000792;membraneless organelle#GO:0043228 p53 pathway#P00059>SIRT-1#P04632 HUMAN|HGNC=19954|UniProtKB=Q9H936 Q9H936 SLC25A22 PTHR45678:SF3 MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED MITOCHONDRIAL GLUTAMATE CARRIER 1 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 intracellular organelle#GO:0043229;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;membrane#GO:0016020;organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 secondary carrier transporter#PC00258;transporter#PC00227 HUMAN|HGNC=13016|UniProtKB=Q9UK11 Q9UK11 ZNF223 PTHR24377:SF982 IP01015P-RELATED ZINC FINGER PROTEIN 223 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=23602|UniProtKB=Q6L8G8 Q6L8G8 KRTAP5-7 PTHR23262:SF226 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 5-7 structural protein#PC00211 HUMAN|HGNC=21702|UniProtKB=Q96N11 Q96N11 INTS15 PTHR14540:SF2 INTEGRATOR COMPLEX SUBUNIT 15 INTEGRATOR COMPLEX SUBUNIT 15 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;integrator complex#GO:0032039;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634 HUMAN|HGNC=26333|UniProtKB=Q8NEF9 Q8NEF9 SRFBP1 PTHR23325:SF1 SERUM RESPONSE FACTOR-BINDING SERUM RESPONSE FACTOR-BINDING PROTEIN 1 cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;maturation of SSU-rRNA#GO:0030490;RNA processing#GO:0006396;biosynthetic process#GO:0009058;metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;ribosomal small subunit biogenesis#GO:0042274;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364 ribonucleoprotein complex#GO:1990904;preribosome#GO:0030684;90S preribosome#GO:0030686;protein-containing complex#GO:0032991 RNA metabolism protein#PC00031 HUMAN|HGNC=16759|UniProtKB=Q6NX49 Q6NX49 ZNF544 PTHR24376:SF38 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 544-RELATED C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=9459|UniProtKB=Q92786 Q92786 PROX1 PTHR12198:SF6 HOMEOBOX PROTEIN PROSPERO/PROX-1/CEH-26 PROSPERO HOMEOBOX PROTEIN 1 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119 HUMAN|HGNC=14253|UniProtKB=P27544 P27544 CERS1 PTHR12560:SF58 LONGEVITY ASSURANCE FACTOR 1 LAG1 CERAMIDE SYNTHASE 1 transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 ceramide metabolic process#GO:0006672;lipid metabolic process#GO:0006629;ceramide biosynthetic process#GO:0046513;sphingolipid biosynthetic process#GO:0030148;metabolic process#GO:0008152;sphingolipid metabolic process#GO:0006665;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;cellular process#GO:0009987;primary metabolic process#GO:0044238 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 metabolite interconversion enzyme#PC00262;transferase#PC00220 HUMAN|HGNC=36|UniProtKB=Q8N139 Q8N139 ABCA6 PTHR19229:SF13 ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 6 molecular carrier activity#GO:0140104;lipid carrier activity#GO:0005319;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399 macromolecule localization#GO:0033036;lipid localization#GO:0010876;transport#GO:0006810;establishment of localization#GO:0051234;localization#GO:0051179;lipid transport#GO:0006869 intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 ATP-binding cassette (ABC) transporter#PC00003 HUMAN|HGNC=25622|UniProtKB=Q9NUY8 Q9NUY8 TBC1D23 PTHR13297:SF10 TBC1 DOMAIN FAMILY MEMBER 23-RELATED TBC1 DOMAIN FAMILY MEMBER 23 cytosolic transport#GO:0016482;animal gross anatomical part developmental process#GO:0160108;embryonic organ development#GO:0048568;anatomical structure development#GO:0048856;cellular localization#GO:0051641;localization#GO:0051179;retrograde transport, endosome to Golgi#GO:0042147;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;multicellular organismal process#GO:0032501;embryo development#GO:0009790;intracellular transport#GO:0046907;transport#GO:0006810;developmental process#GO:0032502;animal organ development#GO:0048513;establishment of localization#GO:0051234;multicellular organism development#GO:0007275;endosomal transport#GO:0016197 Golgi apparatus subcompartment#GO:0098791;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=14785|UniProtKB=Q8NGH7 Q8NGH7 OR52L1 PTHR26450:SF96 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 52L1 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=29654|UniProtKB=Q569H4 Q569H4 PRR16 PTHR15917:SF0 FAMILY NOT NAMED PROTEIN LARGEN biological regulation#GO:0065007;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;regulation of protein metabolic process#GO:0051246;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;regulation of anatomical structure size#GO:0090066;post-transcriptional regulation of gene expression#GO:0010608;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of cellular component size#GO:0032535;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;positive regulation of translation#GO:0045727;regulation of biological quality#GO:0065008;regulation of cell size#GO:0008361;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of protein metabolic process#GO:0051247 HUMAN|HGNC=13301|UniProtKB=Q9BZJ7 Q9BZJ7 GPR62 PTHR22752:SF11 G PROTEIN-COUPLED RECEPTOR G PROTEIN-COUPLED RECEPTOR 62 G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;G protein-coupled receptor signaling pathway#GO:0007186 intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular vesicle#GO:0097708;signaling receptor complex#GO:0043235;cytoplasm#GO:0005737;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=1549|UniProtKB=O75828 O75828 CBR3 PTHR43963:SF3 CARBONYL REDUCTASE 1-RELATED CARBONYL REDUCTASE [NADPH] 3 oxidoreductase activity#GO:0016491;alcohol dehydrogenase (NADP+) activity#GO:0008106;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;catalytic activity#GO:0003824;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 oxidoreductase#PC00176;reductase#PC00198 HUMAN|HGNC=28926|UniProtKB=Q8N1N4 Q8N1N4 KRT78 PTHR45616:SF18 GATA-TYPE DOMAIN-CONTAINING PROTEIN KERATIN, TYPE II CYTOSKELETAL 78 structural molecule activity#GO:0005198 cell differentiation#GO:0030154;intermediate filament cytoskeleton organization#GO:0045104;cellular component organization#GO:0016043;anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;intermediate filament-based process#GO:0045103;animal gross anatomical part developmental process#GO:0160108;keratinocyte differentiation#GO:0030216;intermediate filament organization#GO:0045109;epithelium development#GO:0060429;epithelial cell differentiation#GO:0030855;tissue development#GO:0009888;epidermal cell differentiation#GO:0009913;multicellular organismal process#GO:0032501;skin development#GO:0043588;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;animal organ development#GO:0048513;epidermis development#GO:0008544;developmental process#GO:0032502 membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;supramolecular fiber#GO:0099512;intermediate filament#GO:0005882;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;organelle#GO:0043226;supramolecular complex#GO:0099080;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232 HUMAN|HGNC=29046|UniProtKB=Q9NVF7 Q9NVF7 FBXO28 PTHR13252:SF9 F-BOX ONLY PROTEIN 28 F-BOX ONLY PROTEIN 28 post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;cellular process#GO:0009987;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;protein modification process#GO:0036211;primary metabolic process#GO:0044238;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152 HUMAN|HGNC=21474|UniProtKB=Q9NRR6 Q9NRR6 INPP5E PTHR46625:SF1 72 KDA INOSITOL POLYPHOSPHATE 5-PHOSPHATASE PHOSPHATIDYLINOSITOL POLYPHOSPHATE 5-PHOSPHATASE TYPE IV hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788 lipid modification#GO:0030258;dephosphorylation#GO:0016311;phosphatidylinositol dephosphorylation#GO:0046856;metabolic process#GO:0008152;phosphatidylinositol metabolic process#GO:0046488;lipid metabolic process#GO:0006629;glycerophospholipid metabolic process#GO:0006650;glycerolipid metabolic process#GO:0046486;phospholipid metabolic process#GO:0006644;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;organophosphate metabolic process#GO:0019637;phosphate-containing compound metabolic process#GO:0006796;cellular process#GO:0009987;phospholipid dephosphorylation#GO:0046839 cilium#GO:0005929;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;axoneme#GO:0005930;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoskeleton#GO:0005856;Golgi apparatus#GO:0005794;membraneless organelle#GO:0043228;nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;endomembrane system#GO:0012505;ciliary plasm#GO:0097014 phosphatase#PC00181;hydrolase#PC00121 HUMAN|HGNC=14347|UniProtKB=Q9H6U6 Q9H6U6 BCAS3 PTHR13268:SF0 BREAST CARCINOMA AMPLIFIED SEQUENCE 3 BCAS3 MICROTUBULE ASSOCIATED CELL MIGRATION FACTOR enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047 response to nutrient levels#GO:0031667;response to starvation#GO:0042594;organelle organization#GO:0006996;cellular component organization#GO:0016043;response to stress#GO:0006950;autophagy#GO:0006914;cellular process#GO:0009987;autophagosome organization#GO:1905037;catabolic process#GO:0009056;response to stimulus#GO:0050896;macroautophagy#GO:0016236;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;vacuole organization#GO:0007033;process utilizing autophagic mechanism#GO:0061919 phagophore assembly site#GO:0000407;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 non-motor microtubule binding protein#PC00166 HUMAN|HGNC=26136|UniProtKB=Q9H706 Q9H706 GAREM1 PTHR14454:SF6 GRB2-ASSOCIATED AND REGULATOR OF MAPK PROTEIN FAMILY MEMBER GRB2-ASSOCIATED AND REGULATOR OF MAPK PROTEIN 1 binding#GO:0005488;protein binding#GO:0005515 cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;epidermal growth factor receptor signaling pathway#GO:0007173;cellular process#GO:0009987;ERBB signaling pathway#GO:0038127;signal transduction#GO:0007165;cellular response to growth factor stimulus#GO:0071363;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to growth factor#GO:0070848;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719 HUMAN|HGNC=15349|UniProtKB=Q8NGC7 Q8NGC7 OR11H6 PTHR24242:SF359 G-PROTEIN COUPLED RECEPTOR OLFACTORY RECEPTOR 11H6 G-protein coupled receptor#PC00021 HUMAN|HGNC=18114|UniProtKB=Q5VWX1 Q5VWX1 KHDRBS2 PTHR11208:SF34 RNA-BINDING PROTEIN RELATED KH DOMAIN-CONTAINING, RNA-BINDING, SIGNAL TRANSDUCTION-ASSOCIATED PROTEIN 2 mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;poly(A) binding#GO:0008143;binding#GO:0005488;single-stranded RNA binding#GO:0003727;RNA binding#GO:0003723 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of mRNA processing#GO:0050684;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007;regulation of mRNA metabolic process#GO:1903311;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;regulation of alternative mRNA splicing, via spliceosome#GO:0000381 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 RNA processing factor#PC00147;RNA splicing factor#PC00148 HUMAN|HGNC=28913|UniProtKB=Q8IWL3 Q8IWL3 HSCB PTHR14021:SF20 IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB ATPase activator activity#GO:0001671;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772 iron-sulfur cluster assembly#GO:0016226;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular process#GO:0009987;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739 chaperone#PC00072 HUMAN|HGNC=865|UniProtKB=Q93050 Q93050 ATP6V0A1 PTHR11629:SF68 VACUOLAR PROTON ATPASES V-TYPE PROTON ATPASE 116 KDA SUBUNIT A 1 binding#GO:0005488;enzyme binding#GO:0019899;ATPase-coupled transmembrane transporter activity#GO:0042626;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATP-dependent activity#GO:0140657;protein binding#GO:0005515;monoatomic cation transmembrane transporter activity#GO:0008324;proton transmembrane transporter activity#GO:0015078;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic ion transmembrane transporter activity#GO:0015075;primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804 monoatomic ion homeostasis#GO:0050801;organelle organization#GO:0006996;cellular process#GO:0009987;autophagy#GO:0006914;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;monoatomic cation transmembrane transport#GO:0098655;metabolic process#GO:0008152;chemical homeostasis#GO:0048878;vesicle-mediated transport in synapse#GO:0099003;synaptic vesicle maturation#GO:0016188;cellular component organization or biogenesis#GO:0071840;vesicle organization#GO:0016050;protein-containing complex organization#GO:0043933;cellular component organization#GO:0016043;intracellular monoatomic ion homeostasis#GO:0006873;transmembrane transport#GO:0055085;cellular localization#GO:0051641;cellular component disassembly#GO:0022411;process utilizing autophagic mechanism#GO:0061919;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;developmental maturation#GO:0021700;macroautophagy#GO:0016236;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;autophagosome maturation#GO:0097352;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;transport#GO:0006810;synaptic vesicle cycle#GO:0099504;developmental process#GO:0032502;vacuolar acidification#GO:0007035;establishment of localization#GO:0051234;proton transmembrane transport#GO:1902600;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;catabolic process#GO:0009056;protein-containing complex disassembly#GO:0032984;homeostatic process#GO:0042592;regulation of pH#GO:0006885;regulation of intracellular pH#GO:0051453;localization#GO:0051179;monoatomic cation transport#GO:0006812 ATPase complex#GO:1904949;vacuolar proton-transporting V-type ATPase complex#GO:0016471;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transmembrane transporter complex#GO:1902495;ATPase dependent transmembrane transport complex#GO:0098533;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane protein complex#GO:0098796;cation-transporting ATPase complex#GO:0090533;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;proton-transporting two-sector ATPase complex#GO:0016469;vacuolar membrane#GO:0005774;transporter complex#GO:1990351;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;proton-transporting V-type ATPase complex#GO:0033176;membrane#GO:0016020;cell periphery#GO:0071944;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;vacuole#GO:0005773;plasma membrane#GO:0005886 ATP synthase#PC00002 HUMAN|HGNC=19562|UniProtKB=A4D2G3 A4D2G3 OR2A25 PTHR26451:SF978 G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN OLFACTORY RECEPTOR 2A25 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;binding#GO:0005488 system process#GO:0003008;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;nervous system process#GO:0050877;sensory perception#GO:0007600;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;response to chemical#GO:0042221;response to stimulus#GO:0050896;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;detection of chemical stimulus#GO:0009593 cellular anatomical structure#GO:0110165;membrane#GO:0016020 G-protein coupled receptor#PC00021 HUMAN|HGNC=21408|UniProtKB=Q8IYS1 Q8IYS1 PM20D2 PTHR30575:SF0 PEPTIDASE M20 XAA-ARG DIPEPTIDASE exopeptidase activity#GO:0008238;catalytic activity, acting on a protein#GO:0140096;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;catalytic activity#GO:0003824;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811 modified amino acid metabolic process#GO:0006575;carboxylic acid metabolic process#GO:0019752;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;pteridine-containing compound metabolic process#GO:0042558;folic acid-containing compound metabolic process#GO:0006760;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;small molecule catabolic process#GO:0044282;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 HUMAN|HGNC=29186|UniProtKB=Q9UPS8 Q9UPS8 ANKRD26 PTHR24147:SF60 ANKYRIN REPEAT DOMAIN 36-RELATED ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 26-RELATED HUMAN|HGNC=11200|UniProtKB=Q06945 Q06945 SOX4 PTHR10270:SF27 SOX TRANSCRIPTION FACTOR TRANSCRIPTION FACTOR SOX-4 RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;DNA-binding transcription activator activity#GO:0001216;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;sequence-specific DNA binding#GO:0043565;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228 nervous system development#GO:0007399;head development#GO:0060322;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;sensory system development#GO:0048880;negative regulation of macromolecule biosynthetic process#GO:0010558;animal organ development#GO:0048513;multicellular organism development#GO:0007275;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;neuron differentiation#GO:0030182;positive regulation of transcription by RNA polymerase II#GO:0045944;negative regulation of metabolic process#GO:0009892;sensory organ morphogenesis#GO:0090596;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;central nervous system development#GO:0007417;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;negative regulation of biological process#GO:0048519;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;eye development#GO:0001654;negative regulation of DNA-templated transcription#GO:0045892;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;positive regulation of DNA-templated transcription#GO:0045893;multicellular organismal process#GO:0032501;brain development#GO:0007420;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;camera-type eye morphogenesis#GO:0048593;regulation of primary metabolic process#GO:0080090;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;sensory organ development#GO:0007423;positive regulation of RNA metabolic process#GO:0051254;visual system development#GO:0150063;animal organ morphogenesis#GO:0009887;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;negative regulation of transcription by RNA polymerase II#GO:0000122;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;camera-type eye development#GO:0043010 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HMG box transcription factor#PC00024;DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=23330|UniProtKB=Q8N554 Q8N554 ZNF276 PTHR24406:SF3 TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED ZINC FINGER PROTEIN 276 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=5240|UniProtKB=P48741 P48741 HSPA7 PTHR19375:SF553 HEAT SHOCK PROTEIN 70KDA HEAT SHOCK 70 KDA PROTEIN 6-RELATED protein binding#GO:0005515;hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;ATP-dependent activity#GO:0140657;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;heat shock protein binding#GO:0031072;hydrolase activity, acting on acid anhydrides#GO:0016817 protein folding#GO:0006457;biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein refolding#GO:0042026;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cytosol#GO:0005829;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 chaperone#PC00072;Hsp70 family chaperone#PC00027 Parkinson disease#P00049>Hsp70#P01208;Apoptosis signaling pathway#P00006>HSP70#P00321 HUMAN|HGNC=16890|UniProtKB=O15194 O15194 CTDSPL PTHR12210:SF43 DULLARD PROTEIN PHOSPHATASE CTD SMALL PHOSPHATASE-LIKE PROTEIN protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096 protein phosphatase#PC00195 HUMAN|HGNC=18636|UniProtKB=A5PLK6 A5PLK6 RGSL1 PTHR47079:SF1 REGULATOR OF G-PROTEIN SIGNALING PROTEIN-LIKE REGULATOR OF G PROTEIN SIGNALING PROTEIN-LIKE HUMAN|HGNC=24193|UniProtKB=Q8TD86 Q8TD86 CALML6 PTHR23050:SF558 CALCIUM BINDING PROTEIN CALMODULIN-LIKE PROTEIN 6 cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094 calcium-binding protein#PC00060;calmodulin-related#PC00061 HUMAN|HGNC=8294|UniProtKB=P58180 P58180 OR4D2 PTHR48002:SF132 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 4D2 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=5203|UniProtKB=O75506 O75506 HSBP1 PTHR19424:SF3 HEAT SHOCK FACTOR BINDING PROTEIN 1 HEAT SHOCK FACTOR-BINDING PROTEIN 1 response to stimulus#GO:0050896;response to temperature stimulus#GO:0009266;response to heat#GO:0009408;cellular response to heat#GO:0034605;heat acclimation#GO:0010286;response to stress#GO:0006950;response to abiotic stimulus#GO:0009628;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cellular response to stress#GO:0033554 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cytosol#GO:0005829;nucleus#GO:0005634 HUMAN|HGNC=29570|UniProtKB=Q9UI32 Q9UI32 GLS2 PTHR12544:SF33 GLUTAMINASE GLUTAMINASE LIVER ISOFORM, MITOCHONDRIAL catalytic activity#GO:0003824;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity#GO:0016787 proteinogenic amino acid metabolic process#GO:0170039;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;amino acid metabolic process#GO:0006520;small molecule catabolic process#GO:0044282;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739 hydrolase#PC00121 HUMAN|HGNC=15252|UniProtKB=Q8NH89 Q8NH89 OR5AK3P PTHR48018:SF90 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5AK3 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 nervous system process#GO:0050877;sensory perception#GO:0007600;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signaling#GO:0023052;regulation of cellular process#GO:0050794;sensory perception of smell#GO:0007608;response to stimulus#GO:0050896;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;cellular process#GO:0009987;signal transduction#GO:0007165;biological regulation#GO:0065007;multicellular organismal process#GO:0032501 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=41909|UniProtKB=E0CX11 E0CX11 STMP1 PTHR47709:SF2 SHORT TRANSMEMBRANE MITOCHONDRIAL PROTEIN 1 SHORT TRANSMEMBRANE MITOCHONDRIAL PROTEIN 1 respiratory chain complex#GO:0098803;protein-containing complex#GO:0032991 HUMAN|HGNC=23727|UniProtKB=Q86Y37 Q86Y37 CACUL1 PTHR46636:SF1 CDK2-ASSOCIATED AND CULLIN DOMAIN-CONTAINING PROTEIN 1 CDK2-ASSOCIATED AND CULLIN DOMAIN-CONTAINING PROTEIN 1 binding#GO:0005488;kinase binding#GO:0019900;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;protein binding#GO:0005515 cell cycle#GO:0007049;cell cycle G1/S phase transition#GO:0044843;cellular process#GO:0009987;cell cycle process#GO:0022402;mitotic cell cycle#GO:0000278;cell cycle phase transition#GO:0044770;mitotic cell cycle phase transition#GO:0044772;G1/S transition of mitotic cell cycle#GO:0000082;mitotic cell cycle process#GO:1903047 HUMAN|HGNC=20173|UniProtKB=Q8IXX5 Q8IXX5 TMEM183A PTHR20988:SF2 TRANSMEMBRANE PROTEIN 183A-RELATED TRANSMEMBRANE PROTEIN 183A-RELATED catalytic complex#GO:1902494;transferase complex#GO:1990234;SCF ubiquitin ligase complex#GO:0019005;intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151 HUMAN|HGNC=17283|UniProtKB=Q9UQ26 Q9UQ26 RIMS2 PTHR12157:SF15 REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN 2 structural molecule activity#GO:0005198;structural constituent of synapse#GO:0098918 regulation of signaling#GO:0023051;regulation of neurotransmitter transport#GO:0051588;secretion by cell#GO:0032940;regulation of secretion by cell#GO:1903530;cellular localization#GO:0051641;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;signaling#GO:0023052;export from cell#GO:0140352;regulation of synaptic vesicle exocytosis#GO:2000300;regulation of neurotransmitter secretion#GO:0046928;exocytic process#GO:0140029;regulated exocytosis#GO:0045055;regulation of localization#GO:0032879;exocytosis#GO:0006887;regulation of transport#GO:0051049;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;vesicle-mediated transport in synapse#GO:0099003;synaptic vesicle exocytosis#GO:0016079;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;synaptic signaling#GO:0099536;neurotransmitter transport#GO:0006836;cellular component assembly#GO:0022607;vesicle-mediated transport#GO:0016192;regulation of trans-synaptic signaling#GO:0099177;signal release#GO:0023061;trans-synaptic signaling#GO:0099537;regulation of exocytosis#GO:0017157;localization#GO:0051179;regulation of secretion#GO:0051046;cell communication#GO:0007154;secretion#GO:0046903;chemical synaptic transmission#GO:0007268;signal release from synapse#GO:0099643;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;transport#GO:0006810;synaptic vesicle cycle#GO:0099504;establishment of localization#GO:0051234;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;neurotransmitter secretion#GO:0007269 cytoplasm#GO:0005737;presynaptic membrane#GO:0042734;plasma membrane#GO:0005886;synapse#GO:0045202;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;cell periphery#GO:0071944;presynapse#GO:0098793;cell cortex#GO:0005938;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;presynaptic active zone#GO:0048786;cell junction#GO:0030054;synaptic membrane#GO:0097060 membrane traffic protein#PC00150 Synaptic vesicle trafficking#P05734>RIM1alpha/2alpha#P05776 HUMAN|HGNC=19035|UniProtKB=Q6P0Q8 Q6P0Q8 MAST2 PTHR24356:SF136 SERINE/THREONINE-PROTEIN KINASE MICROTUBULE-ASSOCIATED SERINE_THREONINE-PROTEIN KINASE 2 cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;microtubule binding#GO:0008017;binding#GO:0005488;protein kinase activity#GO:0004672;protein binding#GO:0005515;phosphotransferase activity, alcohol group as acceptor#GO:0016773 cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;organelle organization#GO:0006996;cellular process#GO:0009987;regulation of mitotic cell cycle#GO:0007346;signal transduction#GO:0007165;cellular component organization or biogenesis#GO:0071840;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of cell cycle#GO:0051726;signaling#GO:0023052;cellular component organization#GO:0016043;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;microtubule cytoskeleton#GO:0015630 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=30379|UniProtKB=Q96EE3 Q96EE3 SEH1L PTHR11024:SF3 NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER NUCLEOPORIN SEH1 cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;response to starvation#GO:0042594;regulation of cell communication#GO:0010646;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of signaling#GO:0023051;cellular response to stress#GO:0033554;regulation of intracellular signal transduction#GO:1902531;positive regulation of TOR signaling#GO:0032008;positive regulation of signaling#GO:0023056;cellular process#GO:0009987;regulation of TOR signaling#GO:0032006;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;response to stress#GO:0006950;positive regulation of TORC1 signaling#GO:1904263;response to nutrient levels#GO:0031667;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;cellular response to amino acid starvation#GO:0034198;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;cellular response to nutrient levels#GO:0031669;cellular response to starvation#GO:0009267;regulation of TORC1 signaling#GO:1903432 intracellular anatomical structure#GO:0005622;nuclear pore#GO:0005643;membrane-bounded organelle#GO:0043227;Seh1-associated complex#GO:0035859;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;nucleus#GO:0005634;nuclear pore outer ring#GO:0031080;organelle envelope#GO:0031967 transporter#PC00227 HUMAN|HGNC=3574|UniProtKB=O60427 O60427 FADS1 PTHR19353:SF57 FATTY ACID DESATURASE 2 ACYL-COA (8-3)-DESATURASE oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824 metabolic process#GO:0008152;primary metabolic process#GO:0044238;lipid metabolic process#GO:0006629;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;membrane#GO:0016020 oxidoreductase#PC00176 HUMAN|HGNC=7328|UniProtKB=O43196 O43196 MSH5 PTHR11361:SF20 DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER MUTS PROTEIN HOMOLOG 5 DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;binding#GO:0005488;nucleic acid binding#GO:0003676 cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;homologous chromosome pairing at meiosis#GO:0007129;cellular component assembly#GO:0022607;DNA recombination#GO:0006310;chromosome segregation#GO:0007059;meiotic cell cycle#GO:0051321;chromosome organization involved in meiotic cell cycle#GO:0070192;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;cellular component organization or biogenesis#GO:0071840;homologous chromosome segregation#GO:0045143;cell cycle process#GO:0022402;meiotic cell cycle process#GO:1903046;cellular component organization#GO:0016043;nuclear chromosome segregation#GO:0098813;meiosis I#GO:0007127;reciprocal meiotic recombination#GO:0007131;nuclear division#GO:0000280;nucleobase-containing compound metabolic process#GO:0006139;chromosome organization#GO:0051276;meiotic chromosome segregation#GO:0045132;macromolecule metabolic process#GO:0043170;meiotic nuclear division#GO:0140013;reciprocal homologous recombination#GO:0140527;cell cycle#GO:0007049;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;reproductive process#GO:0022414;homologous recombination#GO:0035825;sexual reproduction#GO:0019953;meiosis I cell cycle process#GO:0061982;organelle fission#GO:0048285 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA metabolism protein#PC00009 HUMAN|HGNC=3819|UniProtKB=Q12778 Q12778 FOXO1 PTHR45767:SF1 FORKHEAD BOX PROTEIN O FORKHEAD BOX PROTEIN O1 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;cellular response to nitrogen compound#GO:1901699;regulation of nucleobase-containing compound metabolic process#GO:0019219;response to peptide hormone#GO:0043434;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of carbohydrate metabolic process#GO:0006109;cellular response to insulin stimulus#GO:0032869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;cellular response to stimulus#GO:0051716;response to insulin#GO:0032868;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;cellular response to peptide hormone stimulus#GO:0071375;regulation of carbohydrate biosynthetic process#GO:0043255;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of DNA-templated transcription#GO:0006355;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of biosynthetic process#GO:0009891;cell communication#GO:0007154;regulation of RNA metabolic process#GO:0051252;response to nitrogen compound#GO:1901698;response to hormone#GO:0009725;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;response to chemical#GO:0042221;cell surface receptor signaling pathway#GO:0007166;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;cellular response to hormone stimulus#GO:0032870;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;signaling#GO:0023052;cellular response to chemical stimulus#GO:0070887;insulin receptor signaling pathway#GO:0008286;response to oxygen-containing compound#GO:1901700;positive regulation of metabolic process#GO:0009893 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 winged helix/forkhead transcription factor#PC00246 CCKR signaling map#P06959>FOXO1#P07167;PI3 kinase pathway#P00048>FOXO#P01198;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>FKHR#P00898 HUMAN|HGNC=33175|UniProtKB=Q5MJ10 Q5MJ10 SPANXN2 PTHR23425:SF7 NUCLEOPORIN AMO1-LIKE SPERM PROTEIN ASSOCIATED WITH THE NUCLEUS ON THE X CHROMOSOME N2-RELATED transporter#PC00227 HUMAN|HGNC=44155|UniProtKB=Q2WGJ8 Q2WGJ8 CATSPERQ PTHR35442:SF1 TRANSMEMBRANE PROTEIN 249 CATION CHANNEL SPERM-ASSOCIATED AUXILIARY SUBUNIT THETA HUMAN|HGNC=30011|UniProtKB=Q9BQY4 Q9BQY4 RHOXF2 PTHR24329:SF567 HOMEOBOX PROTEIN ARISTALESS RHOX HOMEOBOX FAMILY MEMBER 2-RELATED transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;nervous system development#GO:0007399;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;cellular process#GO:0009987;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;developmental process#GO:0032502;neuron differentiation#GO:0030182;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;cell development#GO:0048468;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;system development#GO:0048731;neuron development#GO:0048666;regulation of RNA metabolic process#GO:0051252;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=20449|UniProtKB=Q6TGC4 Q6TGC4 PADI6 PTHR10837:SF4 PEPTIDYLARGININE DEIMINASE INACTIVE PROTEIN-ARGININE DEIMINASE TYPE-6 catalytic activity#GO:0003824;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity#GO:0016787 nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=7174|UniProtKB=P09237 P09237 MMP7 PTHR10201:SF143 MATRIX METALLOPROTEINASE MATRILYSIN metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 catabolic process#GO:0009056;cellular process#GO:0009987;cellular component organization#GO:0016043;external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;extracellular structure organization#GO:0043062;metabolic process#GO:0008152 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 CCKR signaling map#P06959>MMP7#G06996;CCKR signaling map#P06959>MMP7#G07290;Alzheimer disease-presenilin pathway#P00004>Matrix metalloprotease#P00130;Wnt signaling pathway#P00057>Wnt Target Genes#G01558 HUMAN|HGNC=25956|UniProtKB=Q96JG6 Q96JG6 VPS50 PTHR13258:SF0 SYNDETIN SYNDETIN protein binding#GO:0005515;binding#GO:0005488;SNARE binding#GO:0000149 cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;endocytic recycling#GO:0032456;intracellular transport#GO:0046907;transport#GO:0006810;localization within membrane#GO:0051668;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;endosomal transport#GO:0016197;vesicle-mediated transport to the plasma membrane#GO:0098876 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular vesicle#GO:0097708;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;intracellular organelle#GO:0043229;recycling endosome#GO:0055037 HUMAN|HGNC=10528|UniProtKB=Q9NSI8 Q9NSI8 SAMSN1 PTHR12301:SF4 SAM-DOMAIN, SH3 AND NUCLEAR LOCALIZATION SIGNALS PROTEIN RELATED SAM DOMAIN-CONTAINING PROTEIN SAMSN-1 binding#GO:0005488;protein binding#GO:0005515 regulation of B cell activation#GO:0050864;negative regulation of lymphocyte activation#GO:0051250;regulation of multicellular organismal process#GO:0051239;negative regulation of leukocyte activation#GO:0002695;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of immune system process#GO:0002683;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;negative regulation of cell activation#GO:0050866;regulation of cell activation#GO:0050865;regulation of biological process#GO:0050789;regulation of leukocyte activation#GO:0002694;negative regulation of multicellular organismal process#GO:0051241;negative regulation of biological process#GO:0048519;regulation of lymphocyte activation#GO:0051249;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=19055|UniProtKB=Q5RKV6 Q5RKV6 EXOSC6 PTHR11953:SF2 EXOSOME COMPLEX COMPONENT EXOSOME COMPLEX COMPONENT MTR3 binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 RNA 3'-end processing#GO:0031123;macromolecule catabolic process#GO:0009057;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;gene expression#GO:0010467;RNA processing#GO:0006396;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;cellular process#GO:0009987;RNA metabolic process#GO:0016070;RNA catabolic process#GO:0006401;nucleic acid biosynthetic process#GO:0141187;snRNA 3'-end processing#GO:0034472;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulation of gene expression#GO:0010468;snRNA processing#GO:0016180;negative regulation of cellular process#GO:0048523;rRNA metabolic process#GO:0016072;nuclear mRNA surveillance#GO:0071028;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;nucleobase-containing compound catabolic process#GO:0034655;nucleic acid catabolic process#GO:0141188;macromolecule biosynthetic process#GO:0009059;negative regulation of macromolecule metabolic process#GO:0010605;snRNA metabolic process#GO:0016073;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981 RNA metabolism protein#PC00031;exoribonuclease#PC00099 HUMAN|HGNC=27622|UniProtKB=Q6ZNA5 Q6ZNA5 FRRS1 PTHR45828:SF3 CYTOCHROME B561/FERRIC REDUCTASE TRANSMEMBRANE FERRIC REDUCTASE 1 oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on metal ions#GO:0016722;catalytic activity#GO:0003824 monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;chemical homeostasis#GO:0048878;inorganic ion homeostasis#GO:0098771;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;monoatomic ion homeostasis#GO:0050801;intracellular monoatomic ion homeostasis#GO:0006873;intracellular iron ion homeostasis#GO:0006879;homeostatic process#GO:0042592 membrane#GO:0016020;cellular anatomical structure#GO:0110165 reductase#PC00198;oxidoreductase#PC00176 HUMAN|HGNC=15313|UniProtKB=Q8NH51 Q8NH51 OR8K3 PTHR48018:SF28 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 8K3 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 biological regulation#GO:0065007;multicellular organismal process#GO:0032501;signal transduction#GO:0007165;cellular process#GO:0009987;system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606;signaling#GO:0023052;response to stimulus#GO:0050896;sensory perception of smell#GO:0007608;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;sensory perception#GO:0007600;nervous system process#GO:0050877;G protein-coupled receptor signaling pathway#GO:0007186 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=9780|UniProtKB=Q8TBN0 Q8TBN0 RAB3IL1 PTHR14430:SF5 RABIN3-RELATED GUANINE NUCLEOTIDE EXCHANGE FACTOR FOR RAB-3A enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 guanyl-nucleotide exchange factor#PC00113;protein-binding activity modulator#PC00095;G-protein modulator#PC00022 HUMAN|HGNC=18136|UniProtKB=P62341 P62341 SELENOT PTHR13544:SF0 SELENOPROTEIN T THIOREDOXIN REDUCTASE-LIKE SELENOPROTEIN T protein-disulfide reductase activity#GO:0015035;oxidoreductase activity#GO:0016491;catalytic activity, acting on a protein#GO:0140096;disulfide oxidoreductase activity#GO:0015036;antioxidant activity#GO:0016209;catalytic activity#GO:0003824;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667 cellular homeostasis#GO:0019725;homeostatic process#GO:0042592;cell redox homeostasis#GO:0045454 membrane#GO:0016020;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=21067|UniProtKB=Q8IYR2 Q8IYR2 SMYD4 PTHR46165:SF2 SET AND MYND DOMAIN-CONTAINING PROTEIN 4 PROTEIN-LYSINE N-METHYLTRANSFERASE SMYD4 histone deacetylase binding#GO:0042826;protein binding#GO:0005515;enzyme binding#GO:0019899;binding#GO:0005488 circulatory system development#GO:0072359;heart development#GO:0007507;multicellular organismal process#GO:0032501;animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502;multicellular organism development#GO:0007275;animal organ development#GO:0048513;anatomical structure development#GO:0048856;system development#GO:0048731 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=19941|UniProtKB=Q8IXF9 Q8IXF9 AQP12A PTHR21191:SF8 AQUAPORIN AQUAPORIN-12A-RELATED channel activity#GO:0015267;water transmembrane transporter activity#GO:0005372;water channel activity#GO:0015250;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;passive transmembrane transporter activity#GO:0022803 intracellular chemical homeostasis#GO:0055082;regulation of biological quality#GO:0065008;regulation of cell size#GO:0008361;cellular homeostasis#GO:0019725;cellular component organization or biogenesis#GO:0071840;chemical homeostasis#GO:0048878;regulation of anatomical structure size#GO:0090066;homeostatic process#GO:0042592;biological regulation#GO:0065007;regulation of cellular component size#GO:0032535;cellular process#GO:0009987;cellular component organization#GO:0016043 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HUMAN|HGNC=5398|UniProtKB=P13284 P13284 IFI30 PTHR13234:SF81 GAMMA-INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE GILT GAMMA-INTERFERON-INDUCIBLE LYSOSOMAL THIOL REDUCTASE oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 lysosome#GO:0005764;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;vacuole#GO:0005773;intracellular organelle#GO:0043229;lytic vacuole#GO:0000323;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 oxidoreductase#PC00176;reductase#PC00198 HUMAN|HGNC=1479|UniProtKB=P17655 P17655 CAPN2 PTHR10183:SF268 CALPAIN CALPAIN-2 CATALYTIC SUBUNIT cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;cysteine-type endopeptidase activity#GO:0004197;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;proteolysis#GO:0006508;metabolic process#GO:0008152;primary metabolic process#GO:0044238;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 cysteine protease#PC00081;protease#PC00190 Huntington disease#P00029>Calpain#P00788 HUMAN|HGNC=11969|UniProtKB=Q8NDV7 Q8NDV7 TNRC6A PTHR13020:SF28 TRINUCLEOTIDE REPEAT-CONTAINING GENE 6 TRINUCLEOTIDE REPEAT-CONTAINING GENE 6A PROTEIN positive regulation of macromolecule metabolic process#GO:0010604;negative regulation of macromolecule biosynthetic process#GO:0010558;positive regulation of biological process#GO:0048518;regulation of mRNA metabolic process#GO:1903311;positive regulation of mRNA metabolic process#GO:1903313;negative regulation of metabolic process#GO:0009892;negative regulation of gene expression#GO:0010629;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;miRNA-mediated post-transcriptional gene silencing#GO:0035195;regulation of biological process#GO:0050789;positive regulation of metabolic process#GO:0009893;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of biosynthetic process#GO:0009889;positive regulation of catabolic process#GO:0009896;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;regulatory ncRNA-mediated gene silencing#GO:0031047;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;positive regulation of mRNA catabolic process#GO:0061014;regulation of RNA metabolic process#GO:0051252;post-transcriptional gene silencing#GO:0016441;regulatory ncRNA-mediated post-transcriptional gene silencing#GO:0035194 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;P-body#GO:0000932;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;ribonucleoprotein granule#GO:0035770;organelle#GO:0043226;supramolecular complex#GO:0099080 RNA metabolism protein#PC00031 HUMAN|HGNC=18094|UniProtKB=Q30KQ7 Q30KQ7 DEFB113 PTHR39411:SF1 BETA-DEFENSIN 113 BETA-DEFENSIN 113 antimicrobial response protein#PC00051 HUMAN|HGNC=4707|UniProtKB=P54840 P54840 GYS2 PTHR10176:SF1 GLYCOGEN SYNTHASE GLYCOGEN [STARCH] SYNTHASE, LIVER glucosyltransferase activity#GO:0046527;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;hexosyltransferase activity#GO:0016758;UDP-glucosyltransferase activity#GO:0035251;catalytic activity#GO:0003824;transferase activity#GO:0016740 energy derivation by oxidation of organic compounds#GO:0015980;macromolecule metabolic process#GO:0043170;glycogen biosynthetic process#GO:0005978;generation of precursor metabolites and energy#GO:0006091;metabolic process#GO:0008152;carbohydrate biosynthetic process#GO:0016051;biosynthetic process#GO:0009058;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;glucan biosynthetic process#GO:0009250;polysaccharide biosynthetic process#GO:0000271;energy reserve metabolic process#GO:0006112;carbohydrate metabolic process#GO:0005975;polysaccharide metabolic process#GO:0005976;glucan metabolic process#GO:0044042;primary metabolic process#GO:0044238;glycogen metabolic process#GO:0005977 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Glycogen synthase D#P00709 HUMAN|HGNC=6654|UniProtKB=O60663 O60663 LMX1B PTHR24208:SF96 LIM/HOMEOBOX PROTEIN LHX LIM HOMEOBOX TRANSCRIPTION FACTOR 1-BETA nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;nervous system development#GO:0007399;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;neuron differentiation#GO:0030182;developmental process#GO:0032502 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119 HUMAN|HGNC=11697|UniProtKB=P63172 P63172 DYNLT1 PTHR21255:SF19 T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN DYNEIN LIGHT CHAIN TCTEX-TYPE 1 protein binding#GO:0005515;binding#GO:0005488 cellular process#GO:0009987;microtubule-based process#GO:0007017;microtubule-based movement#GO:0007018 cytoskeleton#GO:0005856;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;microtubule cytoskeleton#GO:0015630;cytoplasmic dynein complex#GO:0005868;dynein complex#GO:0030286;organelle#GO:0043226;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737 microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=20714|UniProtKB=Q969W1 Q969W1 ZDHHC16 PTHR12246:SF28 PALMITOYLTRANSFERASE ZDHHC16 PALMITOYLTRANSFERASE ZDHHC16 acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740;palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 animal gross anatomical part developmental process#GO:0160108;cellular response to stress#GO:0033554;developmental process#GO:0032502;DNA damage response#GO:0006974;animal organ development#GO:0048513;anatomical structure development#GO:0048856;multicellular organism development#GO:0007275;system development#GO:0048731;response to stress#GO:0006950;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;multicellular organismal process#GO:0032501;heart development#GO:0007507;response to stimulus#GO:0050896;circulatory system development#GO:0072359 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 protein modifying enzyme#PC00260 HUMAN|HGNC=24599|UniProtKB=Q9UHY7 Q9UHY7 ENOPH1 PTHR20371:SF1 ENOLASE-PHOSPHATASE E1 ENOLASE-PHOSPHATASE E1 hydrolase#PC00121;phosphatase#PC00181 HUMAN|HGNC=5382|UniProtKB=O75874 O75874 IDH1 PTHR11822:SF28 NADP-SPECIFIC ISOCITRATE DEHYDROGENASE ISOCITRATE DEHYDROGENASE [NADP] CYTOPLASMIC nucleotide metabolic process#GO:0009117;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;pyridine-containing compound metabolic process#GO:0072524;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;nucleobase-containing compound metabolic process#GO:0006139;NADP+ metabolic process#GO:0006739;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;organophosphate metabolic process#GO:0019637;purine-containing compound metabolic process#GO:0072521;cellular process#GO:0009987;purine nucleotide metabolic process#GO:0006163;nicotinamide nucleotide metabolic process#GO:0046496 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cytosol#GO:0005829;peroxisome#GO:0005777;mitochondrion#GO:0005739;microbody#GO:0042579 oxidoreductase#PC00176;dehydrogenase#PC00092 HUMAN|HGNC=26427|UniProtKB=Q96ND8 Q96ND8 ZNF583 PTHR24377:SF863 IP01015P-RELATED ZINC FINGER PROTEIN 583 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=2652|UniProtKB=O75881 O75881 CYP7B1 PTHR24304:SF0 CYTOCHROME P450 FAMILY 7 CYTOCHROME P450 7B1 monooxygenase activity#GO:0004497;catalytic activity#GO:0003824;steroid hydroxylase activity#GO:0008395;oxidoreductase activity#GO:0016491 monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;lipid homeostasis#GO:0055088;carboxylic acid biosynthetic process#GO:0046394;small molecule metabolic process#GO:0044281;homeostatic process#GO:0042592;oxoacid metabolic process#GO:0043436;cellular process#GO:0009987;steroid metabolic process#GO:0008202;biosynthetic process#GO:0009058;metabolic process#GO:0008152;chemical homeostasis#GO:0048878;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;monocarboxylic acid biosynthetic process#GO:0072330;cholesterol homeostasis#GO:0042632 oxidoreductase#PC00176;oxygenase#PC00177 HUMAN|HGNC=13842|UniProtKB=A2RRD8 A2RRD8 ZNF320 PTHR24377:SF197 IP01015P-RELATED ZINC FINGER PROTEIN 320 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=29678|UniProtKB=Q9BUK6 Q9BUK6 MSTO1 PTHR13391:SF1 MITOCHONDRIAL DISTRIBUTION REGULATOR MISATO PROTEIN MISATO HOMOLOG 1 cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;mitochondrion organization#GO:0007005;cellular component organization or biogenesis#GO:0071840 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=16771|UniProtKB=Q8IUG1 Q8IUG1 KRTAP1-3 PTHR23262:SF145 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 1-3 structural protein#PC00211 HUMAN|HGNC=7327|UniProtKB=O15457 O15457 MSH4 PTHR11361:SF21 DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER MUTS PROTEIN HOMOLOG 4 double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;binding#GO:0005488;nucleic acid binding#GO:0003676 cell cycle process#GO:0022402;reciprocal homologous recombination#GO:0140527;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;meiosis I#GO:0007127;meiotic cell cycle process#GO:1903046;cell cycle#GO:0007049;reproductive process#GO:0022414;homologous recombination#GO:0035825;reciprocal meiotic recombination#GO:0007131;sexual reproduction#GO:0019953;nuclear division#GO:0000280;meiosis I cell cycle process#GO:0061982;organelle fission#GO:0048285;cellular process#GO:0009987;organelle organization#GO:0006996;nucleobase-containing compound metabolic process#GO:0006139;DNA recombination#GO:0006310;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;meiotic cell cycle#GO:0051321;meiotic nuclear division#GO:0140013;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA metabolism protein#PC00009 HUMAN|HGNC=53641|UniProtKB=A0A1B0GVM2 A0A1B0GVM2 TCAF2C PTHR15730:SF4 EXPERIMENTAL AUTOIMMUNE PROSTATITIS ANTIGEN 2-RELATED TRPM8 CHANNEL-ASSOCIATED FACTOR 2 protein binding#GO:0005515;transmembrane transporter binding#GO:0044325;binding#GO:0005488 regulation of establishment of protein localization#GO:0070201;regulation of protein localization#GO:0032880;regulation of localization#GO:0032879;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;positive regulation of biological process#GO:0048518;regulation of cellular process#GO:0050794;biological regulation#GO:0065007 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=11777|UniProtKB=P22735 P22735 TGM1 PTHR11590:SF49 PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE K transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 epithelium development#GO:0060429;cell differentiation#GO:0030154;tissue development#GO:0009888;epithelial cell differentiation#GO:0030855;epidermal cell differentiation#GO:0009913;skin development#GO:0043588;cellular process#GO:0009987;anatomical structure development#GO:0048856;cellular developmental process#GO:0048869;animal organ development#GO:0048513;keratinocyte differentiation#GO:0030216;animal gross anatomical part developmental process#GO:0160108;epidermis development#GO:0008544;developmental process#GO:0032502 transferase#PC00220 HUMAN|HGNC=15258|UniProtKB=Q8NGF4 Q8NGF4 OR5AP2 PTHR48018:SF21 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5AP2 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;nervous system process#GO:0050877;sensory perception#GO:0007600;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052;regulation of cellular process#GO:0050794;sensory perception of smell#GO:0007608;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;cellular process#GO:0009987;signal transduction#GO:0007165 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=12229|UniProtKB=A0A1B0GX49 A0A1B0GX49 TRBV6-4 PTHR23268:SF19 T-CELL RECEPTOR BETA CHAIN T CELL RECEPTOR BETA VARIABLE 6-2-RELATED signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=28636|UniProtKB=Q9BPU9 Q9BPU9 B9D2 PTHR12968:SF2 B9 DOMAIN-CONTAINING B9 DOMAIN-CONTAINING PROTEIN 2 cilium organization#GO:0044782;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection assembly#GO:0120031;organelle assembly#GO:0070925;plasma membrane bounded cell projection organization#GO:0120036;cell projection organization#GO:0030030;cellular component assembly#GO:0022607;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996 plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cilium#GO:0005929;ciliary transition zone#GO:0035869;membrane-bounded organelle#GO:0043227 structural protein#PC00211 HUMAN|HGNC=11475|UniProtKB=Q15527 Q15527 SURF2 PTHR34348:SF1 SURFEIT LOCUS PROTEIN 2 SURFEIT LOCUS PROTEIN 2 HUMAN|HGNC=13068|UniProtKB=Q96GC6 Q96GC6 ZNF274 PTHR23226:SF93 ZINC FINGER AND SCAN DOMAIN-CONTAINING NEUROTROPHIN RECEPTOR-INTERACTING FACTOR HOMOLOG sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=6218|UniProtKB=Q09470 Q09470 KCNA1 PTHR11537:SF24 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 1 monoatomic cation channel activity#GO:0005261;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;potassium channel activity#GO:0005267;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;transporter activity#GO:0005215;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249 establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;transport#GO:0006810;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;cellular process#GO:0009987;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;metal ion transport#GO:0030001;action potential#GO:0001508 transmembrane transporter complex#GO:1902495;dendritic tree#GO:0097447;axon#GO:0030424;dendrite#GO:0030425;cell projection#GO:0042995;neuronal cell body#GO:0043025;plasma membrane bounded cell projection#GO:0120025;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell body#GO:0044297;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;cell junction#GO:0030054;transporter complex#GO:1990351;cation channel complex#GO:0034703;voltage-gated potassium channel complex#GO:0008076;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;main axon#GO:0044304;neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020 voltage-gated ion channel#PC00241;ion channel#PC00133 HUMAN|HGNC=10738|UniProtKB=Q9H2E6 Q9H2E6 SEMA6A PTHR11036:SF12 SEMAPHORIN SEMAPHORIN-6A signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515;molecular function activator activity#GO:0140677;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772 animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;axonogenesis#GO:0007409;neuron development#GO:0048666;cellular component organization#GO:0016043;positive regulation of cell motility#GO:2000147;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cell morphogenesis#GO:0000902;response to stimulus#GO:0050896;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell development#GO:0048468;signaling#GO:0023052;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell surface receptor signaling pathway#GO:0007166;neuron differentiation#GO:0030182;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cell projection morphogenesis#GO:0048858;neuron projection development#GO:0031175;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;anatomical structure development#GO:0048856;regulation of cell motility#GO:2000145;cell communication#GO:0007154;system development#GO:0048731;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;regulation of neuron migration#GO:2001222;neuron projection morphogenesis#GO:0048812;regulation of cell migration#GO:0030334;developmental process#GO:0032502;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;neuron projection guidance#GO:0097485;positive regulation of locomotion#GO:0040017;axon development#GO:0061564;axon guidance#GO:0007411;positive regulation of cell migration#GO:0030335;positive regulation of cellular process#GO:0048522;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;regulation of locomotion#GO:0040012;biological regulation#GO:0065007 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 membrane-bound signaling molecule#PC00152 HUMAN|HGNC=21411|UniProtKB=Q9BRQ8 Q9BRQ8 AIFM2 PTHR43735:SF27 APOPTOSIS-INDUCING FACTOR 1 FERROPTOSIS SUPPRESSOR PROTEIN 1 nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;binding#GO:0005488;flavin adenine dinucleotide binding#GO:0050660;electron transfer activity#GO:0009055;catalytic activity#GO:0003824;heterocyclic compound binding#GO:1901363;oxidoreductase activity#GO:0016491;nucleotide binding#GO:0000166 regulation of cellular process#GO:0050794;positive regulation of programmed cell death#GO:0043068;cellular component organization#GO:0016043;programmed cell death#GO:0012501;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;cell death#GO:0008219;apoptotic process#GO:0006915;regulation of biological process#GO:0050789;apoptotic mitochondrial changes#GO:0008637;mitochondrion organization#GO:0007005;biological regulation#GO:0065007;organelle organization#GO:0006996;cellular process#GO:0009987;negative regulation of programmed cell death#GO:0043069;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular component organization or biogenesis#GO:0071840;positive regulation of apoptotic process#GO:0043065;negative regulation of cellular process#GO:0048523;regulation of apoptotic process#GO:0042981 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle envelope#GO:0031967;membrane#GO:0016020;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 p53 pathway#P00059>NOXA#G01572 HUMAN|HGNC=14884|UniProtKB=O60884 O60884 DNAJA2 PTHR43888:SF31 DNAJ-LIKE-2, ISOFORM A-RELATED DNAJ HOMOLOG SUBFAMILY A MEMBER 2 protein-folding chaperone binding#GO:0051087;binding#GO:0005488;ATPase activator activity#GO:0001671;protein binding#GO:0005515;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 cellular response to stress#GO:0033554;protein refolding#GO:0042026;protein metabolic process#GO:0019538;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;response to abiotic stimulus#GO:0009628;protein folding#GO:0006457;response to stimulus#GO:0050896;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular response to heat#GO:0034605;response to heat#GO:0009408;response to stress#GO:0006950;biosynthetic process#GO:0009058;response to temperature stimulus#GO:0009266;gene expression#GO:0010467;protein maturation#GO:0051604 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HUMAN|HGNC=17109|UniProtKB=Q8TE56 Q8TE56 ADAMTS17 PTHR13723:SF151 ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 17 catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 primary metabolic process#GO:0044238;cellular component organization#GO:0016043;cellular process#GO:0009987;proteolysis#GO:0006508;metabolic process#GO:0008152;extracellular structure organization#GO:0043062;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;extracellular matrix organization#GO:0030198;protein metabolic process#GO:0019538;external encapsulating structure organization#GO:0045229 external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 HUMAN|HGNC=30650|UniProtKB=Q9BX79 Q9BX79 STRA6 PTHR21444:SF16 COILED-COIL DOMAIN-CONTAINING PROTEIN 180 RECEPTOR FOR RETINOL UPTAKE STRA6 transport#GO:0006810;macromolecule localization#GO:0033036;lipid localization#GO:0010876;organic hydroxy compound transport#GO:0015850;establishment of localization#GO:0051234;localization#GO:0051179;lipid transport#GO:0006869 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HUMAN|HGNC=2092|UniProtKB=Q00610 Q00610 CLTC PTHR10292:SF7 CLATHRIN HEAVY CHAIN RELATED CLATHRIN HEAVY CHAIN 1 protein binding#GO:0005515;binding#GO:0005488;clathrin binding#GO:0030276 localization#GO:0051179;protein-containing complex assembly#GO:0065003;cell cycle#GO:0007049;cellular component organization#GO:0016043;mitotic cell cycle#GO:0000278;endocytosis#GO:0006897;transport#GO:0006810;receptor-mediated endocytosis#GO:0006898;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;import into cell#GO:0098657;establishment of localization#GO:0051234;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;cellular component assembly#GO:0022607;vesicle-mediated transport#GO:0016192 intracellular anatomical structure#GO:0005622;coated vesicle#GO:0030135;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endocytic vesicle#GO:0030139;membrane coat#GO:0030117;coated membrane#GO:0048475;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;clathrin coat#GO:0030118;organelle#GO:0043226;vesicle#GO:0031982;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;clathrin-coated endocytic vesicle#GO:0045334;membraneless organelle#GO:0043228;clathrin-coated vesicle#GO:0030136;cytoskeleton#GO:0005856;spindle#GO:0005819;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;membrane#GO:0016020;microtubule cytoskeleton#GO:0015630 vesicle coat protein#PC00235;membrane traffic protein#PC00150 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Clathrin#P00722;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Clathrin#P00738 HUMAN|HGNC=19138|UniProtKB=Q53EV4 Q53EV4 LRRC23 PTHR15454:SF74 NISCHARIN RELATED LEUCINE-RICH REPEAT-CONTAINING PROTEIN 23 cilium or flagellum-dependent cell motility#GO:0001539;cilium movement#GO:0003341;microtubule bundle formation#GO:0001578;organelle assembly#GO:0070925;axoneme assembly#GO:0035082;cilium organization#GO:0044782;cilium-dependent cell motility#GO:0060285;microtubule cytoskeleton organization#GO:0000226;protein-containing complex assembly#GO:0065003;sperm motility#GO:0097722;cellular component organization#GO:0016043;cilium assembly#GO:0060271;reproductive process#GO:0022414;cell projection organization#GO:0030030;cell motility#GO:0048870;microtubule-based movement#GO:0007018;plasma membrane bounded cell projection assembly#GO:0120031;flagellated sperm motility#GO:0030317;protein-containing complex organization#GO:0043933;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;cell projection assembly#GO:0030031;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cilium movement involved in cell motility#GO:0060294;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HUMAN|HGNC=5293|UniProtKB=P28223 P28223 HTR2A PTHR24247:SF30 5-HYDROXYTRYPTAMINE RECEPTOR 5-HYDROXYTRYPTAMINE RECEPTOR 2A G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;neurotransmitter receptor activity#GO:0030594;G protein-coupled amine receptor activity#GO:0008227;transmembrane signaling receptor activity#GO:0004888 biological regulation#GO:0065007;cell-cell signaling#GO:0007267;response to chemical#GO:0042221;cellular response to nitrogen compound#GO:1901699;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;cellular process#GO:0009987;synaptic signaling#GO:0099536;signaling#GO:0023052;anterograde trans-synaptic signaling#GO:0098916;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;chemical synaptic transmission#GO:0007268;response to nitrogen compound#GO:1901698;cell communication#GO:0007154;response to oxygen-containing compound#GO:1901700;G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887;response to xenobiotic stimulus#GO:0009410;trans-synaptic signaling#GO:0099537 cellular anatomical structure#GO:0110165;somatodendritic compartment#GO:0036477;cell projection#GO:0042995;plasma membrane#GO:0005886;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;dendrite#GO:0030425;dendritic tree#GO:0097447 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GsPCR#P00720;5HT2 type receptor mediated signaling pathway#P04374>5HT2 Receptor#P04414 HUMAN|HGNC=24319|UniProtKB=Q8IY22 Q8IY22 CMIP PTHR25480:SF1 LEUCINE-RICH REPEAT-CONTAINING PROTEIN 73 C-MAF-INDUCING PROTEIN organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;cytosol#GO:0005829;nucleus#GO:0005634;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=33818|UniProtKB=Q6J272 Q6J272 CIMIP2A PTHR47299:SF1 PROTEIN FAM166A CILIARY MICROTUBULE INNER PROTEIN 2A HUMAN|HGNC=24119|UniProtKB=Q9BSW7 Q9BSW7 SYT17 PTHR10024:SF348 SYNAPTOTAGMIN SYNAPTOTAGMIN-17 SNARE binding#GO:0000149;binding#GO:0005488;phospholipid binding#GO:0005543;protein binding#GO:0005515;molecular function regulator activity#GO:0098772;lipid binding#GO:0008289;molecular sensor activity#GO:0140299 transport#GO:0006810;regulation of secretion#GO:0051046;localization#GO:0051179;establishment of localization#GO:0051234;regulation of localization#GO:0032879;regulation of transport#GO:0051049;regulation of exocytosis#GO:0017157;regulation of secretion by cell#GO:1903530;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;cellular process#GO:0009987;regulation of cellular process#GO:0050794;vesicle-mediated transport#GO:0016192;biological regulation#GO:0065007 intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;endomembrane system#GO:0012505;transport vesicle#GO:0030133;cytoplasm#GO:0005737;plasma membrane#GO:0005886;secretory vesicle#GO:0099503;membrane#GO:0016020;cell periphery#GO:0071944 membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=14135|UniProtKB=Q9BRB3 Q9BRB3 PIGQ PTHR21329:SF3 PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q-RELATED PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phospholipid metabolic process#GO:0006644;phospholipid biosynthetic process#GO:0008654;glycolipid metabolic process#GO:0006664;GPI anchored protein biosynthesis#GO:0180046;glycerolipid metabolic process#GO:0046486;liposaccharide metabolic process#GO:1903509;protein metabolic process#GO:0019538;organophosphate biosynthetic process#GO:0090407;glycolipid biosynthetic process#GO:0009247;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;organophosphate metabolic process#GO:0019637;biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467;lipid biosynthetic process#GO:0008610;GPI anchor biosynthetic process#GO:0006506;glycerophospholipid metabolic process#GO:0006650;lipid metabolic process#GO:0006629;GPI anchor metabolic process#GO:0006505;glycerophospholipid biosynthetic process#GO:0046474;metabolic process#GO:0008152;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 glycosyltransferase#PC00111 HUMAN|HGNC=2596|UniProtKB=P05177 P05177 CYP1A2 PTHR24299:SF7 CYTOCHROME P450 FAMILY 1 CYTOCHROME P450 1A2 monooxygenase activity#GO:0004497;steroid hydroxylase activity#GO:0008395;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 lipid catabolic process#GO:0016042;cellular process#GO:0009987;steroid metabolic process#GO:0008202;biological regulation#GO:0065007;cellular response to xenobiotic stimulus#GO:0071466;hormone metabolic process#GO:0042445;response to chemical#GO:0042221;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;secondary metabolic process#GO:0019748;cellular response to stimulus#GO:0051716;regulation of hormone levels#GO:0010817;primary metabolic process#GO:0044238;xenobiotic metabolic process#GO:0006805;catabolic process#GO:0009056;response to stimulus#GO:0050896;response to xenobiotic stimulus#GO:0009410;cellular response to chemical stimulus#GO:0070887;regulation of biological quality#GO:0065008;steroid catabolic process#GO:0006706;estrogen metabolic process#GO:0008210 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 oxygenase#PC00177;oxidoreductase#PC00176 HUMAN|HGNC=11600|UniProtKB=Q9Y458 Q9Y458 TBX22 PTHR11267:SF116 T-BOX PROTEIN-RELATED T-BOX TRANSCRIPTION FACTOR TBX22 RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;cell fate specification#GO:0001708;developmental process#GO:0032502;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA metabolic process#GO:0051252;cell fate commitment#GO:0045165;regulation of DNA-templated transcription#GO:0006355 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694;chromatin#GO:0000785;nucleus#GO:0005634 immunoglobulin fold transcription factor#PC00251;Rel homology transcription factor#PC00252 HUMAN|HGNC=24851|UniProtKB=A6NMB1 A6NMB1 SIGLEC16 PTHR12035:SF96 SIALIC ACID BINDING IMMUNOGLOBULIN-LIKE LECTIN SIALIC ACID-BINDING IG-LIKE LECTIN 16 carboxylic acid binding#GO:0031406;anion binding#GO:0043168;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;carbohydrate derivative binding#GO:0097367;organic acid binding#GO:0043177 cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 cell adhesion molecule#PC00069;immunoglobulin superfamily cell adhesion molecule#PC00125 HUMAN|HGNC=2263|UniProtKB=Q7KZN9 Q7KZN9 COX15 PTHR23289:SF2 CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15 HEME A SYNTHASE COX15 chaperone#PC00072 Vitamin D metabolism and pathway#P04396>FDX#P04607 HUMAN|HGNC=26489|UniProtKB=Q6P9G4 Q6P9G4 TMEM154 PTHR36526:SF1 TRANSMEMBRANE PROTEIN 154 TRANSMEMBRANE PROTEIN 154 HUMAN|HGNC=5834|UniProtKB=P06312 P06312 IGKV4-1 PTHR23267:SF425 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN KAPPA VARIABLE 4-1 immune response#GO:0006955;immune system process#GO:0002376;response to stimulus#GO:0050896 protein-containing complex#GO:0032991 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=15459|UniProtKB=Q9UBL9 Q9UBL9 P2RX2 PTHR10125:SF4 P2X PURINOCEPTOR P2X PURINOCEPTOR 2 monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;gated channel activity#GO:0022836;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion channel activity#GO:0005216;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;ligand-gated monoatomic cation channel activity#GO:0099094;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 cellular process#GO:0009987;calcium ion transmembrane transport#GO:0070588;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;calcium ion transport#GO:0006816;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;establishment of localization#GO:0051234 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;signaling receptor complex#GO:0043235;cell periphery#GO:0071944 ligand-gated ion channel#PC00141 HUMAN|HGNC=5421|UniProtKB=P05015 P05015 IFNA16 PTHR11691:SF71 TYPE I INTERFERON INTERFERON ALPHA-16 receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;cytokine activity#GO:0005125;cytokine receptor binding#GO:0005126;signaling receptor binding#GO:0005102;binding#GO:0005488;molecular function activator activity#GO:0140677;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 cellular response to stimulus#GO:0051716;leukocyte activation#GO:0045321;response to external biotic stimulus#GO:0043207;regulation of cellular process#GO:0050794;cell activation#GO:0001775;cytokine-mediated signaling pathway#GO:0019221;response to nitrogen compound#GO:1901698;cell communication#GO:0007154;immune response#GO:0006955;biological regulation#GO:0065007;adaptive immune response#GO:0002250;response to other organism#GO:0051707;multicellular organismal process#GO:0032501;response to external stimulus#GO:0009605;defense response#GO:0006952;innate immune response#GO:0045087;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;T cell activation#GO:0042110;biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052;response to stimulus#GO:0050896;immune system process#GO:0002376;B cell activation involved in immune response#GO:0002312;type I interferon-mediated signaling pathway#GO:0060337;response to peptide#GO:1901652;cell activation involved in immune response#GO:0002263;defense response to symbiont#GO:0140546;lymphocyte activation involved in immune response#GO:0002285;signal transduction#GO:0007165;cellular process#GO:0009987;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;T cell activation involved in immune response#GO:0002286;lymphocyte activation#GO:0046649;response to cytokine#GO:0034097;response to chemical#GO:0042221;defense response to other organism#GO:0098542;cell surface receptor signaling pathway#GO:0007166;leukocyte activation involved in immune response#GO:0002366;natural killer cell activation#GO:0030101;immune effector process#GO:0002252;humoral immune response#GO:0006959;B cell activation#GO:0042113 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 interferon superfamily#PC00127;cytokine#PC00083 HUMAN|HGNC=19702|UniProtKB=Q96HA1 Q96HA1 POM121 PTHR23193:SF47 NUCLEAR PORE COMPLEX PROTEIN NUP NUCLEAR ENVELOPE PORE MEMBRANE PROTEIN POM 121 molecular carrier activity#GO:0140104;nucleocytoplasmic carrier activity#GO:0140142;structural constituent of nuclear pore#GO:0017056;structural molecule activity#GO:0005198 nucleocytoplasmic transport#GO:0006913;protein transport#GO:0015031;protein import into nucleus#GO:0006606;nuclear export#GO:0051168;nuclear transport#GO:0051169;nucleic acid transport#GO:0050657;cellular localization#GO:0051641;localization#GO:0051179;establishment of RNA localization#GO:0051236;RNA localization#GO:0006403;protein localization to organelle#GO:0033365;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;nitrogen compound transport#GO:0071705;protein localization to nucleus#GO:0034504;import into nucleus#GO:0051170;macromolecule localization#GO:0033036 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;nuclear pore#GO:0005643;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;organelle envelope#GO:0031967;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 transporter#PC00227 HUMAN|HGNC=14604|UniProtKB=Q9BXJ7 Q9BXJ7 AMN PTHR14995:SF2 AMNIONLESS PROTEIN AMNIONLESS transport#GO:0006810;renal absorption#GO:0070293;localization#GO:0051179;establishment of localization#GO:0051234;import into cell#GO:0098657;intracellular protein localization#GO:0008104;system process#GO:0003008;receptor-mediated endocytosis#GO:0006898;macromolecule localization#GO:0033036;cellular process#GO:0009987;renal system process#GO:0003014;vesicle-mediated transport#GO:0016192;multicellular organismal process#GO:0032501;endocytosis#GO:0006897 intracellular organelle#GO:0043229;endocytic vesicle#GO:0030139;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;vesicle#GO:0031982;apical plasma membrane#GO:0016324;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;apical part of cell#GO:0045177;signaling receptor complex#GO:0043235;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;plasma membrane region#GO:0098590;protein-containing complex#GO:0032991 HUMAN|HGNC=12827|UniProtKB=Q9UBH6 Q9UBH6 XPR1 PTHR10783:SF141 XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED SOLUTE CARRIER FAMILY 53 MEMBER 1 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;phosphate transmembrane transporter activity#GO:0005315;efflux transmembrane transporter activity#GO:0015562;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;inorganic anion transport#GO:0015698;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;transport#GO:0006810;inorganic ion homeostasis#GO:0098771;chemical homeostasis#GO:0048878;export from cell#GO:0140352;homeostatic process#GO:0042592;phosphate ion transport#GO:0006817;cellular process#GO:0009987 organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;trans-Golgi network#GO:0005802;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020 secondary carrier transporter#PC00258 HUMAN|HGNC=28971|UniProtKB=Q14159 Q14159 SPIDR PTHR34347:SF1 DNA REPAIR-SCAFFOLDING PROTEIN SPIDR DNA REPAIR-SCAFFOLDING PROTEIN regulation of establishment of protein localization#GO:0070201;regulation of protein localization#GO:0032880;recombinational repair#GO:0000725;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of biological process#GO:0050789;double-strand break repair via homologous recombination#GO:0000724;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;regulation of localization#GO:0032879;double-strand break repair#GO:0006302;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;DNA recombination#GO:0006310;DNA damage response#GO:0006974;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;response to stress#GO:0006950;cellular process#GO:0009987 membraneless organelle#GO:0043228;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;chromosome#GO:0005694;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 DNA metabolism protein#PC00009 HUMAN|HGNC=7504|UniProtKB=Q13505 Q13505 MTX1 PTHR12289:SF34 METAXIN RELATED METAXIN-1 establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;intracellular protein localization#GO:0008104;establishment of protein localization to membrane#GO:0090150;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of protein localization#GO:0045184;mitochondrial membrane organization#GO:0007006;establishment of localization in cell#GO:0051649;cellular component assembly#GO:0022607;protein insertion into membrane#GO:0051205;membrane organization#GO:0061024;mitochondrion organization#GO:0007005;protein insertion into mitochondrial outer membrane#GO:0045040;localization within membrane#GO:0051668;cellular localization#GO:0051641;localization#GO:0051179;cellular component organization#GO:0016043;protein localization to mitochondrion#GO:0070585;protein-containing complex assembly#GO:0065003;protein localization to organelle#GO:0033365 outer membrane#GO:0019867;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;membrane protein complex#GO:0098796;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrial outer membrane translocase complex#GO:0005742;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;mitochondrial outer membrane#GO:0005741;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;membrane#GO:0016020;cytoplasm#GO:0005737;mitochondrial protein-containing complex#GO:0098798;organelle outer membrane#GO:0031968;protein-containing complex#GO:0032991 transporter#PC00227 HUMAN|HGNC=587|UniProtKB=P27695 P27695 APEX1 PTHR22748:SF6 AP ENDONUCLEASE DNA REPAIR NUCLEASE_REDOX REGULATOR APEX1 endonuclease activity#GO:0004519;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;DNA nuclease activity#GO:0004536;hydrolase activity#GO:0016787;catalytic activity, acting on DNA#GO:0140097;phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578;3'-5' exonuclease activity#GO:0008408;DNA exonuclease activity#GO:0004529;DNA endonuclease activity#GO:0004520;nuclease activity#GO:0004518;DNA exonuclease activity, producing 5'-phosphomonoesters#GO:0016895;3'-5'-DNA exonuclease activity#GO:0008296;exonuclease activity#GO:0004527 DNA damage response#GO:0006974;cellular response to stress#GO:0033554;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;macromolecule metabolic process#GO:0043170;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;base-excision repair#GO:0006284;response to stress#GO:0006950;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;nucleobase-containing compound metabolic process#GO:0006139;response to stimulus#GO:0050896 HUMAN|HGNC=29285|UniProtKB=Q6VN20 Q6VN20 RANBP10 PTHR12864:SF19 RAN BINDING PROTEIN 9-RELATED RAN-BINDING PROTEIN 10 enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 proteasomal protein catabolic process#GO:0010498;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;ubiquitin-dependent protein catabolic process#GO:0006511;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;catabolic process#GO:0009056;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;protein metabolic process#GO:0019538;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163 transferase complex#GO:1990234;catalytic complex#GO:1902494;ubiquitin ligase complex#GO:0000151;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737 scaffold/adaptor protein#PC00226 HUMAN|HGNC=26866|UniProtKB=Q8IYK2 Q8IYK2 TEKTL1 PTHR35081:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 105 TEKTIN-LIKE PROTEIN 1 HUMAN|HGNC=30255|UniProtKB=Q9Y255 Q9Y255 PRELID1 PTHR11158:SF31 MSF1/PX19 RELATED PRELI DOMAIN-CONTAINING PROTEIN 1, MITOCHONDRIAL molecular carrier activity#GO:0140104;lipid carrier activity#GO:0005319;transporter activity#GO:0005215;phospholipid transfer activity#GO:0120014;lipid transfer activity#GO:0120013 organophosphate ester transport#GO:0015748;lipid transport#GO:0006869;phospholipid transport#GO:0015914;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;localization#GO:0051179;lipid localization#GO:0010876;transport#GO:0006810 mitochondrion#GO:0005739;mitochondrial envelope#GO:0005740;organelle envelope#GO:0031967;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;mitochondrial intermembrane space#GO:0005758;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 transfer/carrier protein#PC00219 HUMAN|HGNC=25328|UniProtKB=P0DX53 P0DX53 GOLGA8G PTHR10881:SF7 GOLGIN SUBFAMILY A MEMBER-RELATED GOLGIN SUBFAMILY A CONSERVED DOMAIN-CONTAINING PROTEIN-RELATED cellular process#GO:0009987;Golgi organization#GO:0007030;cellular component organization#GO:0016043;organelle organization#GO:0006996;endomembrane system organization#GO:0010256;cellular component organization or biogenesis#GO:0071840 intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;Golgi stack#GO:0005795;organelle membrane#GO:0031090;cis-Golgi network#GO:0005801;Golgi apparatus#GO:0005794;cytoplasm#GO:0005737;Golgi cis cisterna#GO:0000137;endomembrane system#GO:0012505;Golgi cisterna#GO:0031985;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020 membrane traffic protein#PC00150 HUMAN|HGNC=21037|UniProtKB=Q8TBC5 Q8TBC5 ZSCAN18 PTHR23226:SF157 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 18 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=24218|UniProtKB=Q03701 Q03701 CEBPZ PTHR12048:SF0 CCAAT-BINDING FACTOR-RELATED CCAAT_ENHANCER-BINDING PROTEIN ZETA intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HUMAN|HGNC=6462|UniProtKB=P78386 P78386 KRT85 PTHR45616:SF43 GATA-TYPE DOMAIN-CONTAINING PROTEIN KERATIN, TYPE II CUTICULAR HB5 structural molecule activity#GO:0005198 supramolecular fiber organization#GO:0097435;anatomical structure development#GO:0048856;intermediate filament organization#GO:0045109;intermediate filament-based process#GO:0045103;keratinocyte differentiation#GO:0030216;animal gross anatomical part developmental process#GO:0160108;cell differentiation#GO:0030154;intermediate filament cytoskeleton organization#GO:0045104;cellular component organization#GO:0016043;cellular component organization or biogenesis#GO:0071840;animal organ development#GO:0048513;cellular developmental process#GO:0048869;developmental process#GO:0032502;epidermis development#GO:0008544;cytoskeleton organization#GO:0007010;skin development#GO:0043588;epithelium development#GO:0060429;epidermal cell differentiation#GO:0009913;tissue development#GO:0009888;multicellular organismal process#GO:0032501;epithelial cell differentiation#GO:0030855;cellular process#GO:0009987;organelle organization#GO:0006996 membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;intermediate filament#GO:0005882;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232 HUMAN|HGNC=15594|UniProtKB=Q9UK59 Q9UK59 DBR1 PTHR12849:SF0 RNA LARIAT DEBRANCHING ENZYME LARIAT DEBRANCHING ENZYME endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;RNA endonuclease activity#GO:0004521;catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;nuclease activity#GO:0004518;hydrolase activity#GO:0016787 RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA catabolic process#GO:0006401;catabolic process#GO:0009056;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;macromolecule metabolic process#GO:0043170;macromolecule catabolic process#GO:0009057;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound catabolic process#GO:0034655;mRNA processing#GO:0006397;nucleic acid catabolic process#GO:0141188;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 endoribonuclease#PC00094 HUMAN|HGNC=6066|UniProtKB=P08476 P08476 INHBA PTHR11848:SF133 TGF-BETA FAMILY INHIBIN BETA A CHAIN cytokine activity#GO:0005125;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546 cell surface receptor signaling pathway#GO:0007166;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 growth factor#PC00112 Gonadotropin-releasing hormone receptor pathway#P06664>Inhba#P06723;Gonadotropin-releasing hormone receptor pathway#P06664>Inhba/b#P06700;TGF-beta signaling pathway#P00052>TGFbeta#P01286 HUMAN|HGNC=243|UniProtKB=P35611 P35611 ADD1 PTHR10672:SF4 ADDUCIN ALPHA-ADDUCIN actin filament binding#GO:0051015;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;binding#GO:0005488;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 regulation of cellular component organization#GO:0051128;negative regulation of actin filament polymerization#GO:0030837;regulation of cellular component biogenesis#GO:0044087;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;regulation of protein-containing complex assembly#GO:0043254;regulation of cellular component size#GO:0032535;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;regulation of multicellular organismal development#GO:2000026;negative regulation of actin filament depolymerization#GO:0030835;regulation of biological quality#GO:0065008;regulation of actin filament length#GO:0030832;positive regulation of cellular component organization#GO:0051130;positive regulation of cell development#GO:0010720;regulation of multicellular organismal process#GO:0051239;regulation of actin cytoskeleton organization#GO:0032956;regulation of protein-containing complex disassembly#GO:0043244;regulation of epithelial cell differentiation#GO:0030856;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;regulation of anatomical structure size#GO:0090066;positive regulation of cell differentiation#GO:0045597;regulation of cytoskeleton organization#GO:0051493;regulation of protein polymerization#GO:0032271;negative regulation of supramolecular fiber organization#GO:1902904;regulation of cellular process#GO:0050794;regulation of developmental process#GO:0050793;regulation of actin filament depolymerization#GO:0030834;negative regulation of cellular component organization#GO:0051129;negative regulation of organelle organization#GO:0010639;regulation of supramolecular fiber organization#GO:1902903;negative regulation of cytoskeleton organization#GO:0051494;negative regulation of protein-containing complex disassembly#GO:0043242;negative regulation of protein-containing complex assembly#GO:0031333;actin filament capping#GO:0051693;negative regulation of protein polymerization#GO:0032272;regulation of actin filament polymerization#GO:0030833;biological regulation#GO:0065007;regulation of actin polymerization or depolymerization#GO:0008064;negative regulation of protein depolymerization#GO:1901880;positive regulation of cellular process#GO:0048522;regulation of actin filament organization#GO:0110053;regulation of cell development#GO:0060284;regulation of protein depolymerization#GO:1901879;regulation of actin filament-based process#GO:0032970;negative regulation of cellular process#GO:0048523;positive regulation of developmental process#GO:0051094;regulation of cell differentiation#GO:0045595 postsynaptic density#GO:0014069;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;postsynapse#GO:0098794;cellular anatomical structure#GO:0110165;synapse#GO:0045202;asymmetric synapse#GO:0032279;organelle#GO:0043226;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;cell junction#GO:0030054;adherens junction#GO:0005912;membrane#GO:0016020;cell-cell junction#GO:0005911;cell periphery#GO:0071944;neuron to neuron synapse#GO:0098984;postsynaptic specialization#GO:0099572;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886 non-motor actin binding protein#PC00165 HUMAN|HGNC=12859|UniProtKB=O00237 O00237 RNF103 PTHR15302:SF0 E3 UBIQUITIN-PROTEIN LIGASE RNF103 E3 UBIQUITIN-PROTEIN LIGASE RNF103 aminoacyltransferase activity#GO:0016755;ubiquitin-protein transferase activity#GO:0004842;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;response to chemical#GO:0042221;protein ubiquitination#GO:0016567;proteasomal protein catabolic process#GO:0010498;post-translational protein modification#GO:0043687;response to stress#GO:0006950;cellular process#GO:0009987;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;ERAD pathway#GO:0036503;protein modification by small protein conjugation or removal#GO:0070647;response to endoplasmic reticulum stress#GO:0034976;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;catabolic process#GO:0009056;response to stimulus#GO:0050896;primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein modification by small protein conjugation#GO:0032446;cellular response to stimulus#GO:0051716 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=40053|UniProtKB=A0A1B0GWK0 A0A1B0GWK0 PVALEF PTHR23064:SF29 TROPONIN PARVALBUMIN-LIKE EF-HAND-CONTAINING PROTEIN multicellular organismal process#GO:0032501;skeletal muscle contraction#GO:0003009;striated muscle contraction#GO:0006941;muscle system process#GO:0003012;system process#GO:0003008;muscle contraction#GO:0006936;neuromuscular process#GO:0050905;nervous system process#GO:0050877 contractile muscle fiber#GO:0043292;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;cytoskeleton#GO:0005856;sarcomere#GO:0030017;membraneless organelle#GO:0043228;actin cytoskeleton#GO:0015629;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;myofibril#GO:0030016 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=27820|UniProtKB=Q86XE3 Q86XE3 MICU3 PTHR12294:SF10 EF HAND DOMAIN FAMILY A1,A2-RELATED CALCIUM UPTAKE PROTEIN 3, MITOCHONDRIAL metal ion binding#GO:0046872;cation binding#GO:0043169;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;calcium ion binding#GO:0005509 monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;metal ion transport#GO:0030001;homeostatic process#GO:0042592;mitochondrial calcium ion homeostasis#GO:0051560;intracellular monoatomic ion homeostasis#GO:0006873;calcium ion transmembrane transport#GO:0070588;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;calcium ion transport#GO:0006816;cellular homeostasis#GO:0019725;establishment of localization#GO:0051234;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;intracellular monoatomic cation homeostasis#GO:0030003;transport#GO:0006810;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987;mitochondrial calcium ion transmembrane transport#GO:0006851;monoatomic ion homeostasis#GO:0050801 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transmembrane transporter complex#GO:1902495;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;calcium channel complex#GO:0034704;membrane protein complex#GO:0098796;organelle envelope#GO:0031967;organelle membrane#GO:0031090;transporter complex#GO:1990351;inner mitochondrial membrane protein complex#GO:0098800;cation channel complex#GO:0034703;cytoplasm#GO:0005737;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrial membrane#GO:0031966;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743 calmodulin-related#PC00061;calcium-binding protein#PC00060 HUMAN|HGNC=23690|UniProtKB=Q8TAX9 Q8TAX9 GSDMB PTHR16399:SF20 GASDERMIN GASDERMIN-B phospholipid binding#GO:0005543;phosphatidylinositol phosphate binding#GO:1901981;ion binding#GO:0043167;phosphatidylinositol-4,5-bisphosphate binding#GO:0005546;anion binding#GO:0043168;binding#GO:0005488;small molecule binding#GO:0036094;phosphatidylserine binding#GO:0001786;phosphatidylinositol bisphosphate binding#GO:1902936;lipid binding#GO:0008289 response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to other organism#GO:0051707;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;response to external stimulus#GO:0009605;defense response#GO:0006952;response to bacterium#GO:0009617;inflammatory response#GO:0006954;defense response to bacterium#GO:0042742 transporter#PC00227 HUMAN|HGNC=5525|UniProtKB=P01857 P01857 IGHG1 PTHR23411:SF39 TAPASIN IMMUNOGLOBULIN HEAVY CONSTANT GAMMA 1-RELATED antigen binding#GO:0003823;signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515 immune response#GO:0006955;complement activation#GO:0006956;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;adaptive immune response#GO:0002250;response to other organism#GO:0051707;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;response to external stimulus#GO:0009605;defense response#GO:0006952;regulation of immune system process#GO:0002682;response to external biotic stimulus#GO:0043207;response to bacterium#GO:0009617;regulation of immune response#GO:0050776;response to biotic stimulus#GO:0009607;positive regulation of immune system process#GO:0002684;response to stress#GO:0006950;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;defense response to symbiont#GO:0140546;defense response to other organism#GO:0098542;antimicrobial humoral response#GO:0019730;humoral immune response#GO:0006959;immune effector process#GO:0002252;antibacterial humoral response#GO:0019731;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;immune system process#GO:0002376;defense response to bacterium#GO:0042742;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449;immunoglobulin mediated immune response#GO:0016064;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460 extracellular protein-containing complex#GO:0140392;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=28682|UniProtKB=Q8N141 Q8N141 ZFP82 PTHR24377:SF734 IP01015P-RELATED ZINC FINGER PROTEIN 82 HOMOLOG binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=17077|UniProtKB=O14595 O14595 CTDSP2 PTHR12210:SF187 DULLARD PROTEIN PHOSPHATASE CARBOXY-TERMINAL DOMAIN RNA POLYMERASE II POLYPEPTIDE A SMALL PHOSPHATASE 2 catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721;protein serine/threonine phosphatase activity#GO:0004722 protein phosphatase#PC00195 HUMAN|HGNC=33744|UniProtKB=Q7Z7N9 Q7Z7N9 TMEM179B PTHR31056:SF1 TRANSMEMBRANE PROTEIN 179B TRANSMEMBRANE PROTEIN 179B HUMAN|HGNC=21155|UniProtKB=Q8WY64 Q8WY64 MYLIP PTHR23280:SF13 4.1 G PROTEIN E3 UBIQUITIN-PROTEIN LIGASE MYLIP transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842 cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;catabolic process#GO:0009056;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 actin or actin-binding cytoskeletal protein#PC00041;non-motor actin binding protein#PC00165;cytoskeletal protein#PC00085 HUMAN|HGNC=19699|UniProtKB=Q9NYY3 Q9NYY3 PLK2 PTHR24345:SF44 SERINE/THREONINE-PROTEIN KINASE PLK SERINE_THREONINE-PROTEIN KINASE PLK2 catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 G1/S transition of mitotic cell cycle#GO:0000082;regulation of synaptic plasticity#GO:0048167;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;mitotic cell cycle process#GO:1903047;organelle organization#GO:0006996;cellular process#GO:0009987;cell cycle G1/S phase transition#GO:0044843;regulation of trans-synaptic signaling#GO:0099177;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;mitotic cell cycle phase transition#GO:0044772;regulation of signaling#GO:0023051;microtubule cytoskeleton organization#GO:0000226;regulation of biological quality#GO:0065008;cellular component organization#GO:0016043;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cell cycle#GO:0007049;cell cycle process#GO:0022402;regulation of biological process#GO:0050789;mitotic spindle organization#GO:0007052;cell cycle phase transition#GO:0044770;regulation of cellular process#GO:0050794;mitotic cell cycle#GO:0000278;regulation of cell communication#GO:0010646;modulation of chemical synaptic transmission#GO:0050804 spindle pole#GO:0000922;chromosome#GO:0005694;kinetochore#GO:0000776;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;microtubule cytoskeleton#GO:0015630;condensed chromosome, centromeric region#GO:0000779;nucleus#GO:0005634;supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232;centriole#GO:0005814;cytoplasm#GO:0005737;microtubule organizing center#GO:0005815;spindle#GO:0005819;centrosome#GO:0005813;cytoskeleton#GO:0005856;condensed chromosome#GO:0000793;chromosome, centromeric region#GO:0000775;membraneless organelle#GO:0043228 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=29938|UniProtKB=Q8WUQ7 Q8WUQ7 CACTIN PTHR21737:SF6 POLYGLUTAMINE BINDING PROTEIN 1/MARVEL MEMBRANE-ASSOCIATING DOMAIN CONTAINING 3 SPLICING FACTOR CACTIN RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;negative regulation of response to external stimulus#GO:0032102;RNA processing#GO:0006396;negative regulation of innate immune response#GO:0045824;regulation of response to external stimulus#GO:0032101;gene expression#GO:0010467;cellular process#GO:0009987;mRNA processing#GO:0006397;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;mRNA metabolic process#GO:0016071;mRNA cis splicing, via spliceosome#GO:0045292;mRNA splicing, via spliceosome#GO:0000398;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of innate immune response#GO:0045088;macromolecule metabolic process#GO:0043170;regulation of response to stimulus#GO:0048583;regulation of response to stress#GO:0080134;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;negative regulation of immune system process#GO:0002683;biosynthetic process#GO:0009058;negative regulation of response to stimulus#GO:0048585;macromolecule biosynthetic process#GO:0009059;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;regulation of immune response#GO:0050776;negative regulation of immune response#GO:0050777;regulation of defense response#GO:0031347;RNA splicing, via transesterification reactions#GO:0000375;RNA biosynthetic process#GO:0032774;regulation of response to biotic stimulus#GO:0002831;negative regulation of defense response#GO:0031348;regulation of immune system process#GO:0002682;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 nucleus#GO:0005634;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513 scaffold/adaptor protein#PC00226 HUMAN|HGNC=17289|UniProtKB=Q96BJ8 Q96BJ8 ELMO3 PTHR12771:SF16 ENGULFMENT AND CELL MOTILITY ENGULFMENT AND CELL MOTILITY PROTEIN 3 cell migration#GO:0016477;response to chemical#GO:0042221;taxis#GO:0042330;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;actin filament organization#GO:0007015;response to external stimulus#GO:0009605;actin cytoskeleton organization#GO:0030036;cell motility#GO:0048870;response to stimulus#GO:0050896;locomotion#GO:0040011;cellular component organization#GO:0016043;cellular response to stimulus#GO:0051716;cell chemotaxis#GO:0060326;supramolecular fiber organization#GO:0097435;cellular response to chemical stimulus#GO:0070887;actin filament-based process#GO:0030029;chemotaxis#GO:0006935 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HUMAN|HGNC=30456|UniProtKB=Q96DA0 Q96DA0 ZG16B PTHR33589:SF1 OS11G0524900 PROTEIN PANCREATIC ADENOCARCINOMA UP-REGULATED FACTOR cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=10334|UniProtKB=P62899 P62899 RPL31 PTHR10956:SF4 60S RIBOSOMAL PROTEIN L31 LARGE RIBOSOMAL SUBUNIT PROTEIN EL31 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;translation#GO:0006412;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;cytoplasmic translation#GO:0002181;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytosolic large ribosomal subunit#GO:0022625;cytosolic ribosome#GO:0022626;cytosol#GO:0005829;ribosome#GO:0005840;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232 translational protein#PC00263;ribosomal protein#PC00202 HUMAN|HGNC=25555|UniProtKB=Q9NVN3 Q9NVN3 RIC8B PTHR12425:SF2 SYNEMBRYN CHAPERONE RIC-8B guanyl-nucleotide exchange factor activity#GO:0005085;binding#GO:0005488;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;protein binding#GO:0005515;GTPase regulator activity#GO:0030695 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;cytosol#GO:0005829 HUMAN|HGNC=11206|UniProtKB=P23497 P23497 SP100 PTHR46386:SF15 NUCLEAR BODY PROTEIN SP140 NUCLEAR AUTOANTIGEN SP-100 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=33843|UniProtKB=Q7Z6K4 Q7Z6K4 NRARP PTHR24203:SF75 ANKYRIN REPEAT FAMILY PROTEIN NOTCH-REGULATED ANKYRIN REPEAT-CONTAINING PROTEIN HUMAN|HGNC=33146|UniProtKB=Q6ZMV5 Q6ZMV5 PPP4R3C PTHR23318:SF19 ATP SYNTHASE GAMMA-RELATED PROTEIN PPP4R3C enzyme activator activity#GO:0008047;phosphatase regulator activity#GO:0019208;enzyme regulator activity#GO:0030234;protein phosphatase regulator activity#GO:0019888;phosphatase activator activity#GO:0019211;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 regulation of response to stress#GO:0080134;regulation of DNA repair#GO:0006282;regulation of response to stimulus#GO:0048583;DNA damage response#GO:0006974;regulation of metabolic process#GO:0019222;response to stress#GO:0006950;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;cellular response to stress#GO:0033554;regulation of cellular response to stress#GO:0080135;regulation of double-strand break repair#GO:2000779;cellular response to stimulus#GO:0051716;regulation of DNA metabolic process#GO:0051052;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;response to stimulus#GO:0050896 protein serine/threonine phosphatase complex#GO:0008287;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226 ATP synthase#PC00002 HUMAN|HGNC=28304|UniProtKB=Q96EC8 Q96EC8 YIPF6 PTHR21236:SF1 GOLGI MEMBRANE PROTEIN YIP1 PROTEIN YIPF6 organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;trans-Golgi network#GO:0005802;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;Golgi apparatus subcompartment#GO:0098791 structural protein#PC00211 HUMAN|HGNC=33605|UniProtKB=A6NHM9 A6NHM9 MOXD2P PTHR10157:SF31 DOPAMINE BETA HYDROXYLASE RELATED DBH-LIKE MONOOXYGENASE PROTEIN 2-RELATED oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;monooxygenase activity#GO:0004497;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 membrane#GO:0016020;secretory vesicle#GO:0099503;vesicle membrane#GO:0012506;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;vesicle#GO:0031982;intracellular vesicle#GO:0097708;secretory granule membrane#GO:0030667;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;extracellular region#GO:0005576;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141 hydroxylase#PC00122 HUMAN|HGNC=11226|UniProtKB=Q96JI7 Q96JI7 SPG11 PTHR13650:SF2 SPATACSIN SPATACSIN cell development#GO:0048468;signaling#GO:0023052;cell morphogenesis#GO:0000902;establishment of organelle localization#GO:0051656;cell projection organization#GO:0030030;cell differentiation#GO:0030154;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;neuron development#GO:0048666;axonogenesis#GO:0007409;cellular localization#GO:0051641;microtubule-based transport#GO:0099111;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;establishment of vesicle localization#GO:0051650;synaptic vesicle localization#GO:0097479;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;synaptic vesicle transport#GO:0048489;synaptic signaling#GO:0099536;neuron projection development#GO:0031175;microtubule-based process#GO:0007017;cell projection morphogenesis#GO:0048858;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;microtubule-based movement#GO:0007018;anterograde trans-synaptic signaling#GO:0098916;chemical synaptic transmission#GO:0007268;system development#GO:0048731;anatomical structure development#GO:0048856;localization#GO:0051179;cell communication#GO:0007154;trans-synaptic signaling#GO:0099537;organelle localization#GO:0051640;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;multicellular organismal process#GO:0032501;cytoskeleton-dependent intracellular transport#GO:0030705;vesicle localization#GO:0051648;axo-dendritic transport#GO:0008088;axon development#GO:0061564;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;transport#GO:0006810;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;intracellular transport#GO:0046907 intracellular anatomical structure#GO:0005622;cell junction#GO:0030054;dendritic tree#GO:0097447;axon#GO:0030424;dendrite#GO:0030425;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;somatodendritic compartment#GO:0036477;cellular anatomical structure#GO:0110165;synapse#GO:0045202;neuron projection#GO:0043005 HUMAN|HGNC=1162|UniProtKB=Q70Z53 Q70Z53 FRA10AC1 PTHR11567:SF25 ACID PHOSPHATASE-RELATED PROTEIN FRA10AC1 hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788 phosphatase#PC00181 HUMAN|HGNC=24592|UniProtKB=Q658P3 Q658P3 STEAP3 PTHR14239:SF8 DUDULIN-RELATED METALLOREDUCTASE STEAP3 catalytic activity#GO:0003824;ferric-chelate reductase activity#GO:0000293;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on metal ions#GO:0016722 transport#GO:0006810;transition metal ion transport#GO:0000041;localization#GO:0051179;monoatomic cation transport#GO:0006812;establishment of localization#GO:0051234;metal ion transport#GO:0030001;monoatomic ion transport#GO:0006811 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;membrane#GO:0016020;vesicle#GO:0031982;cell periphery#GO:0071944;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endosome#GO:0005768 reductase#PC00198 HUMAN|HGNC=25341|UniProtKB=Q6ZWK4 Q6ZWK4 RHEX PTHR38491:SF1 REGULATOR OF HEMOGLOBINIZATION AND ERYTHROID CELL EXPANSION PROTEIN REGULATOR OF HEMOGLOBINIZATION AND ERYTHROID CELL EXPANSION PROTEIN HUMAN|HGNC=29609|UniProtKB=Q9NPH0 Q9NPH0 ACP6 PTHR11567:SF202 ACID PHOSPHATASE-RELATED LYSOPHOSPHATIDIC ACID PHOSPHATASE TYPE 6 phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578 carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phospholipid metabolic process#GO:0006644;glycerolipid metabolic process#GO:0046486;glycerophospholipid metabolic process#GO:0006650;lipid metabolic process#GO:0006629;metabolic process#GO:0008152 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 phosphatase#PC00181 HUMAN|HGNC=2939|UniProtKB=P51530 P51530 DNA2 PTHR10887:SF433 DNA2/NAM7 HELICASE FAMILY DNA REPLICATION ATP-DEPENDENT HELICASE_NUCLEASE DNA2 catalytic activity#GO:0003824;DNA endonuclease activity, producing 5'-phosphomonoesters#GO:0016888;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity, acting on ester bonds#GO:0016788;DNA nuclease activity#GO:0004536;catalytic activity, acting on DNA#GO:0140097;endonuclease activity#GO:0004519;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA endonuclease activity#GO:0004520;RNA binding#GO:0003723;hydrolase activity#GO:0016787;nuclease activity#GO:0004518 DNA-templated DNA replication#GO:0006261;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;nucleobase-containing compound metabolic process#GO:0006139;replication fork processing#GO:0031297;DNA replication#GO:0006260;cellular process#GO:0009987;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 RNA helicase#PC00032 DNA replication#P00017>Hel#P00532 HUMAN|HGNC=25683|UniProtKB=Q9HAC8 Q9HAC8 UBTD1 PTHR13609:SF11 UBIQUITIN DOMAIN CONTAINING 1 PROTEIN-RELATED UBIQUITIN DOMAIN-CONTAINING PROTEIN 1 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=5035|UniProtKB=P07910 P07910 HNRNPC PTHR13968:SF3 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEINS C1_C2 nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 RNA metabolism protein#PC00031 HUMAN|HGNC=10982|UniProtKB=O75746 O75746 SLC25A12 PTHR45678:SF7 MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED ELECTROGENIC ASPARTATE_GLUTAMATE ANTIPORTER SLC25A12, MITOCHONDRIAL amino acid transmembrane transporter activity#GO:0015171;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;dicarboxylic acid transmembrane transporter activity#GO:0005310;L-glutamate transmembrane transporter activity#GO:0005313;acidic amino acid transmembrane transporter activity#GO:0015172;L-amino acid transmembrane transporter activity#GO:0015179;C4-dicarboxylate transmembrane transporter activity#GO:0015556;carboxylic acid transmembrane transporter activity#GO:0046943 primary metabolic process#GO:0044238;L-alpha-amino acid transmembrane transport#GO:1902475;carboxylic acid transmembrane transport#GO:1905039;nucleoside phosphate metabolic process#GO:0006753;pyridine-containing compound metabolic process#GO:0072524;L-glutamate import#GO:0051938;localization#GO:0051179;amino acid transmembrane transport#GO:0003333;organophosphate metabolic process#GO:0019637;aspartate transmembrane transport#GO:0015810;L-amino acid transport#GO:0015807;NAD+ metabolic process#GO:0019674;nitrogen compound transport#GO:0071705;nucleobase-containing compound metabolic process#GO:0006139;dicarboxylic acid transport#GO:0006835;C4-dicarboxylate transport#GO:0015740;transport#GO:0006810;establishment of localization#GO:0051234;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;phosphorus metabolic process#GO:0006793;small molecule metabolic process#GO:0044281;nucleotide metabolic process#GO:0009117;transmembrane transport#GO:0055085;nicotinamide nucleotide metabolic process#GO:0046496;cellular process#GO:0009987;L-glutamate transmembrane transport#GO:0015813;organic acid transport#GO:0015849;carboxylic acid transport#GO:0046942;amino acid transport#GO:0006865;acidic amino acid transport#GO:0015800;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086 mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;mitochondrial inner membrane#GO:0005743;organelle envelope#GO:0031967;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622 secondary carrier transporter#PC00258;transporter#PC00227 HUMAN|HGNC=9796|UniProtKB=P53611 P53611 RABGGTB PTHR11774:SF11 GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT BETA catalytic activity, acting on a protein#GO:0140096;prenyltransferase activity#GO:0004659;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;catalytic activity#GO:0003824;transferase activity#GO:0016740 protein targeting to membrane#GO:0006612;localization within membrane#GO:0051668;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;establishment of protein localization to membrane#GO:0090150;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein targeting#GO:0006605 catalytic complex#GO:1902494;transferase complex#GO:1990234;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 acyltransferase#PC00042;transferase#PC00220 HUMAN|HGNC=14999|UniProtKB=Q8NGZ3 Q8NGZ3 OR13G1 PTHR26451:SF237 G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN OLFACTORY RECEPTOR 13G1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;binding#GO:0005488 nervous system process#GO:0050877;sensory perception#GO:0007600;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;system process#GO:0003008;detection of chemical stimulus#GO:0009593;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;response to stimulus#GO:0050896;response to chemical#GO:0042221 cellular anatomical structure#GO:0110165;membrane#GO:0016020 G-protein coupled receptor#PC00021 HUMAN|HGNC=22009|UniProtKB=Q6ZVC0 Q6ZVC0 NYAP1 PTHR22633:SF2 NEURONAL TYROSINE-PHOSPHORYLATED PHOSPHOINOSITIDE-3-KINASE ADAPTER 2-RELATED NEURONAL TYROSINE-PHOSPHORYLATED PHOSPHOINOSITIDE-3-KINASE ADAPTER 1 plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cell projection morphogenesis#GO:0048858;neuron projection development#GO:0031175;cellular process#GO:0009987;signal transduction#GO:0007165;nervous system development#GO:0007399;intracellular signaling cassette#GO:0141124;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;neuron development#GO:0048666;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;response to stimulus#GO:0050896;cell differentiation#GO:0030154;cell development#GO:0048468;signaling#GO:0023052;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0043491;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;anatomical structure development#GO:0048856;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;system development#GO:0048731;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794 scaffold/adaptor protein#PC00226 HUMAN|HGNC=471|UniProtKB=P49418 P49418 AMPH PTHR46514:SF2 AMPHIPHYSIN AMPHIPHYSIN binding#GO:0005488;phospholipid binding#GO:0005543;lipid binding#GO:0008289 cellular process#GO:0009987;establishment of localization in cell#GO:0051649;synaptic vesicle endocytosis#GO:0048488;vesicle-mediated transport#GO:0016192;synaptic vesicle recycling#GO:0036465;endocytosis#GO:0006897;synaptic vesicle cycle#GO:0099504;transport#GO:0006810;import into cell#GO:0098657;establishment of localization#GO:0051234;cellular localization#GO:0051641;vesicle-mediated transport in synapse#GO:0099003;localization#GO:0051179 membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;synaptic vesicle#GO:0008021;intracellular vesicle#GO:0097708;cell junction#GO:0030054;plasma membrane#GO:0005886;cytoplasm#GO:0005737;transport vesicle#GO:0030133;endomembrane system#GO:0012505;presynapse#GO:0098793;cell periphery#GO:0071944;secretory vesicle#GO:0099503;membrane#GO:0016020 HUMAN|HGNC=21461|UniProtKB=Q9HBD1 Q9HBD1 RC3H2 PTHR13139:SF2 RING FINGER AND CCCH-TYPE ZINC FINGER DOMAIN-CONTAINING PROTEIN ROQUIN-2 aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;RNA binding#GO:0003723;double-stranded RNA binding#GO:0003725;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;mRNA binding#GO:0003729;acyltransferase activity#GO:0016746;nucleic acid binding#GO:0003676;binding#GO:0005488 protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;regulation of biological process#GO:0050789;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;regulation of mRNA stability#GO:0043488;protein catabolic process#GO:0030163;RNA catabolic process#GO:0006401;modification-dependent macromolecule catabolic process#GO:0043632;protein modification by small protein conjugation or removal#GO:0070647;regulation of biological quality#GO:0065008;positive regulation of metabolic process#GO:0009893;RNA metabolic process#GO:0016070;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;RNA destabilization#GO:0050779;protein ubiquitination#GO:0016567;positive regulation of macromolecule metabolic process#GO:0010604;metabolic process#GO:0008152;positive regulation of mRNA metabolic process#GO:1903313;macromolecule catabolic process#GO:0009057;mRNA destabilization#GO:0061157;regulation of mRNA metabolic process#GO:1903311;modification-dependent protein catabolic process#GO:0019941;positive regulation of mRNA catabolic process#GO:0061014;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;protein modification process#GO:0036211;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;regulation of RNA stability#GO:0043487;regulation of RNA metabolic process#GO:0051252;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;nucleic acid catabolic process#GO:0141188;nucleobase-containing compound catabolic process#GO:0034655;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;post-translational protein modification#GO:0043687;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;ubiquitin-dependent protein catabolic process#GO:0006511;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;macromolecule metabolic process#GO:0043170;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;positive regulation of catabolic process#GO:0009896;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic stress granule#GO:0010494;membraneless organelle#GO:0043228;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;organelle#GO:0043226 HUMAN|HGNC=27196|UniProtKB=Q8IYB9 Q8IYB9 ZNF595 PTHR24377:SF303 IP01015P-RELATED ZINC FINGER PROTEIN 595 binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=9794|UniProtKB=Q9UI14 Q9UI14 RABAC1 PTHR19317:SF0 PRENYLATED RAB ACCEPTOR 1-RELATED PRENYLATED RAB ACCEPTOR PROTEIN 1 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 membrane traffic protein#PC00150 HUMAN|HGNC=14956|UniProtKB=Q8N387 Q8N387 MUC15 PTHR45427:SF1 MUCIN-15 MUCIN-15 HUMAN|HGNC=18105|UniProtKB=Q8N687 Q8N687 DEFB125 PTHR15001:SF13 BETA-DEFENSIN 123-RELATED BETA-DEFENSIN 125 defense response to symbiont#GO:0140546;immune response#GO:0006955;cellular process#GO:0009987;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to other organism#GO:0051707;response to stimulus#GO:0050896;defense response to other organism#GO:0098542;immune system process#GO:0002376;cell killing#GO:0001906;response to external stimulus#GO:0009605;defense response#GO:0006952;innate immune response#GO:0045087 defense/immunity protein#PC00090;antimicrobial response protein#PC00051 HUMAN|HGNC=25151|UniProtKB=Q96EY9 Q96EY9 ADAT3 PTHR11079:SF156 CYTOSINE DEAMINASE FAMILY MEMBER TRNA-SPECIFIC ADENOSINE-34 DEAMINASE REGULATORY SUBUNIT ADAT3 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 deaminase#PC00088;metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HUMAN|HGNC=1692|UniProtKB=P08962 P08962 CD63 PTHR19282:SF471 TETRASPANIN CD63 ANTIGEN regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;regulation of biological process#GO:0050789;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cellular response to growth factor stimulus#GO:0090287;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HUMAN|HGNC=29931|UniProtKB=Q9BVP2 Q9BVP2 GNL3 PTHR11089:SF11 GTP-BINDING PROTEIN-RELATED GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 3 intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013 HUMAN|HGNC=10573|UniProtKB=O95171 O95171 SCEL PTHR15468:SF7 ZNF185 SCIELLIN animal gross anatomical part developmental process#GO:0160108;epidermis development#GO:0008544;developmental process#GO:0032502;tissue development#GO:0009888;anatomical structure development#GO:0048856 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=25504|UniProtKB=Q96A72 Q96A72 MAGOHB PTHR12638:SF1 PROTEIN MAGO NASHI HOMOLOG PROTEIN MAGO NASHI HOMOLOG 2 regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;nucleic acid biosynthetic process#GO:0141187;RNA catabolic process#GO:0006401;RNA metabolic process#GO:0016070;cellular process#GO:0009987;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;RNA processing#GO:0006396;gene expression#GO:0010467;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay#GO:0000184;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule catabolic process#GO:0009057;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;macromolecule biosynthetic process#GO:0009059;nucleic acid catabolic process#GO:0141188;nucleobase-containing compound catabolic process#GO:0034655;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;biosynthetic process#GO:0009058;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;nuclear mRNA surveillance#GO:0071028;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889 exon-exon junction complex#GO:0035145;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;spliceosomal complex#GO:0005681;nucleus#GO:0005634 HUMAN|HGNC=19331|UniProtKB=Q96EY8 Q96EY8 MMAB PTHR12213:SF0 CORRINOID ADENOSYLTRANSFERASE CORRINOID ADENOSYLTRANSFERASE MMAB transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;transferase activity#GO:0016740;catalytic activity#GO:0003824 oxidoreductase#PC00176;dehydrogenase#PC00092 HUMAN|HGNC=12577|UniProtKB=O00322 O00322 UPK1A PTHR19282:SF25 TETRASPANIN UROPLAKIN-1A cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HUMAN|HGNC=25721|UniProtKB=Q86VS3 Q86VS3 IQCH PTHR14465:SF0 IQ DOMAIN-CONTAINING PROTEIN H IQ DOMAIN-CONTAINING PROTEIN H HUMAN|HGNC=21180|UniProtKB=Q5TGI4 Q5TGI4 SAMD5 PTHR12301:SF8 SAM-DOMAIN, SH3 AND NUCLEAR LOCALIZATION SIGNALS PROTEIN RELATED STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 5 regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;regulation of intracellular signal transduction#GO:1902531;regulation of biological process#GO:0050789;regulation of cell communication#GO:0010646;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cellular process#GO:0050794 HUMAN|HGNC=6948|UniProtKB=P33992 P33992 MCM5 PTHR11630:SF42 DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER DNA REPLICATION LICENSING FACTOR MCM5 ATP-dependent activity, acting on DNA#GO:0008094;ATP-dependent activity#GO:0140657;helicase activity#GO:0004386;catalytic activity, acting on DNA#GO:0140097;isomerase activity#GO:0016853;3'-5' DNA helicase activity#GO:0043138;DNA helicase activity#GO:0003678;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;macromolecular conformation isomerase activity#GO:0120543 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular response to stimulus#GO:0051716;double-strand break repair via homologous recombination#GO:0000724;DNA replication#GO:0006260;response to stimulus#GO:0050896;recombinational repair#GO:0000725;cellular response to stress#GO:0033554;DNA-templated DNA replication#GO:0006261;response to stress#GO:0006950;double-strand break repair via break-induced replication#GO:0000727;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;DNA damage response#GO:0006974;DNA replication initiation#GO:0006270;DNA recombination#GO:0006310;macromolecule metabolic process#GO:0043170;double-strand break repair#GO:0006302 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 DNA metabolism protein#PC00009 Apoptosis signaling pathway#P00006>HSP70#P00321;Parkinson disease#P00049>Hsp70#P01208 HUMAN|HGNC=12991|UniProtKB=Q9BSG1 Q9BSG1 ZNF2 PTHR24377:SF885 IP01015P-RELATED ZINC FINGER PROTEIN 2 transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=21111|UniProtKB=Q6AI39 Q6AI39 BICRAL PTHR15572:SF2 GLIOMA TUMOR SUPPRESSOR CANDIDATE REGION GENE 1 BRD4-INTERACTING CHROMATIN-REMODELING COMPLEX-ASSOCIATED PROTEIN-LIKE regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;chromatin#GO:0000785;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ATPase complex#GO:1904949;SWI/SNF complex#GO:0016514;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;SWI/SNF superfamily-type complex#GO:0070603;chromosome#GO:0005694 HUMAN|HGNC=11014|UniProtKB=Q99726 Q99726 SLC30A3 PTHR11562:SF30 CATION EFFLUX PROTEIN/ ZINC TRANSPORTER PROTON-COUPLED ZINC ANTIPORTER SLC30A3-RELATED metal ion transmembrane transporter activity#GO:0046873;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;transition metal ion transmembrane transporter activity#GO:0046915;zinc ion transmembrane transporter activity#GO:0005385 response to stimulus#GO:0050896;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;transition metal ion transport#GO:0000041;zinc ion transmembrane transport#GO:0071577;response to chemical#GO:0042221;zinc ion transport#GO:0006829;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;cellular process#GO:0009987;establishment of localization#GO:0051234;transport#GO:0006810;response to metal ion#GO:0010038 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227 HUMAN|HGNC=8716|UniProtKB=Q9UN70 Q9UN70 PCDHGC3 PTHR24028:SF362 CADHERIN-87A PROTOCADHERIN GAMMA-C3 cellular process#GO:0009987;cell adhesion#GO:0007155 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cadherin#PC00057;cell adhesion molecule#PC00069 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HUMAN|HGNC=4832|UniProtKB=P69892 P69892 HBG2 PTHR11442:SF89 HEMOGLOBIN FAMILY MEMBER HEMOGLOBIN SUBUNIT GAMMA-2 protein binding#GO:0005515;tetrapyrrole binding#GO:0046906;molecular carrier activity#GO:0140104;binding#GO:0005488;heme binding#GO:0020037 multicellular organismal-level homeostasis#GO:0048871;establishment of localization#GO:0051234;cellular developmental process#GO:0048869;transport#GO:0006810;developmental process#GO:0032502;hemopoiesis#GO:0030097;multicellular organismal process#GO:0032501;cellular process#GO:0009987;anatomical structure development#GO:0048856;erythrocyte differentiation#GO:0030218;localization#GO:0051179;homeostasis of number of cells#GO:0048872;immune system process#GO:0002376;cell development#GO:0048468;homeostatic process#GO:0042592;myeloid cell differentiation#GO:0030099;cell differentiation#GO:0030154 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 globin#PC00107;transfer/carrier protein#PC00219 HUMAN|HGNC=30833|UniProtKB=O75956 O75956 CDK2AP2 PTHR22607:SF4 DELETED IN ORAL CANCER 1/CDK2-ASSOCIATED PROTEIN 1 CYCLIN-DEPENDENT KINASE 2-ASSOCIATED PROTEIN 2 negative regulation of cellular process#GO:0048523;negative regulation of cell cycle process#GO:0010948;negative regulation of cell cycle#GO:0045786;regulation of mitotic cell cycle#GO:0007346;negative regulation of mitotic cell cycle phase transition#GO:1901991;regulation of microtubule cytoskeleton organization#GO:0070507;regulation of cell cycle process#GO:0010564;biological regulation#GO:0065007;regulation of microtubule-based process#GO:0032886;regulation of G1/S transition of mitotic cell cycle#GO:2000045;regulation of mitotic cell cycle phase transition#GO:1901990;negative regulation of mitotic cell cycle#GO:0045930;negative regulation of cell cycle phase transition#GO:1901988;regulation of cell cycle phase transition#GO:1901987;negative regulation of biological process#GO:0048519;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;regulation of cell cycle G1/S phase transition#GO:1902806;regulation of cell cycle#GO:0051726 membrane-bounded organelle#GO:0043227;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;nucleus#GO:0005634;microtubule cytoskeleton#GO:0015630 kinase inhibitor#PC00139;kinase modulator#PC00140 HUMAN|HGNC=30021|UniProtKB=Q9BYK8 Q9BYK8 HELZ2 PTHR10887:SF516 DNA2/NAM7 HELICASE FAMILY 3'-5' EXORIBONUCLEASE HELZ2 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 regulatory ncRNA-mediated post-transcriptional gene silencing#GO:0035194;post-transcriptional gene silencing#GO:0016441;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulatory ncRNA-mediated gene silencing#GO:0031047;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007 intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;P granule#GO:0043186;cytosol#GO:0005829;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737 RNA helicase#PC00032 HUMAN|HGNC=1354|UniProtKB=P07360 P07360 C8G PTHR47304:SF1 COMPLEMENT COMPONENT C8 GAMMA CHAIN COMPLEMENT COMPONENT C8 GAMMA CHAIN humoral immune response#GO:0006959;immune effector process#GO:0002252;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;innate immune response#GO:0045087;defense response#GO:0006952;response to external stimulus#GO:0009605;response to stress#GO:0006950;positive regulation of immune system process#GO:0002684;response to biotic stimulus#GO:0009607;activation of immune response#GO:0002253;positive regulation of biological process#GO:0048518;defense response to symbiont#GO:0140546;complement activation#GO:0006956;immune response#GO:0006955;defense response to other organism#GO:0098542;positive regulation of response to stimulus#GO:0048584;response to other organism#GO:0051707;biological regulation#GO:0065007;immune system process#GO:0002376;regulation of immune response#GO:0050776;regulation of biological process#GO:0050789;regulation of immune system process#GO:0002682;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207 plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 complement component#PC00078 HUMAN|HGNC=30092|UniProtKB=P43490 P43490 NAMPT PTHR43816:SF1 NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE pentosyltransferase activity#GO:0016763;transferase activity#GO:0016740;catalytic activity#GO:0003824;glycosyltransferase activity#GO:0016757 nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;nicotinamide nucleotide metabolic process#GO:0046496;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;NAD+ metabolic process#GO:0019674;nucleobase-containing small molecule metabolic process#GO:0055086;nucleoside phosphate biosynthetic process#GO:1901293;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;nucleotide metabolic process#GO:0009117;organophosphate biosynthetic process#GO:0090407;pyridine-containing compound metabolic process#GO:0072524;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522 metabolite interconversion enzyme#PC00262;transferase#PC00220 HUMAN|HGNC=23092|UniProtKB=Q8TCU3 Q8TCU3 SLC7A13 PTHR11785:SF238 AMINO ACID TRANSPORTER SOLUTE CARRIER FAMILY 7 MEMBER 13 carboxylic acid transmembrane transporter activity#GO:0046943;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;amino acid transmembrane transporter activity#GO:0015171;L-amino acid transmembrane transporter activity#GO:0015179 localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;amino acid transmembrane transport#GO:0003333;amino acid transport#GO:0006865;transport#GO:0006810;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227 HUMAN|HGNC=8010|UniProtKB=Q9Y4C0 Q9Y4C0 NRXN3 PTHR15036:SF57 PIKACHURIN-LIKE PROTEIN NEUREXIN-3 binding#GO:0005488;signaling receptor binding#GO:0005102;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;protein binding#GO:0005515;signaling receptor activity#GO:0038023 biological regulation#GO:0065007;multicellular organismal process#GO:0032501;macromolecule localization#GO:0033036;system process#GO:0003008;intracellular protein localization#GO:0008104;developmental process#GO:0032502;postsynapse organization#GO:0099173;cell junction organization#GO:0034330;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;system development#GO:0048731;postsynaptic specialization organization#GO:0099084;cell communication#GO:0007154;localization#GO:0051179;anatomical structure development#GO:0048856;synapse organization#GO:0050808;protein localization to cell junction#GO:1902414;organelle assembly#GO:0070925;cognition#GO:0050890;nervous system development#GO:0007399;cellular component assembly#GO:0022607;signal transduction#GO:0007165;cellular process#GO:0009987;postsynaptic density assembly#GO:0097107;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular component organization or biogenesis#GO:0071840;protein localization to synapse#GO:0035418;multicellular organism development#GO:0007275;excitatory synapse assembly#GO:1904861;signaling#GO:0023052;response to stimulus#GO:0050896;synapse assembly#GO:0007416;regulation of biological process#GO:0050789;cell junction assembly#GO:0034329;cellular component organization#GO:0016043;nervous system process#GO:0050877;postsynaptic density organization#GO:0097106;animal gross anatomical part developmental process#GO:0160108 cell junction#GO:0030054;presynaptic active zone#GO:0048786;synaptic membrane#GO:0097060;plasma membrane#GO:0005886;presynaptic membrane#GO:0042734;plasma membrane region#GO:0098590;synapse#GO:0045202;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;presynapse#GO:0098793;cell periphery#GO:0071944;presynaptic active zone membrane#GO:0048787;membrane#GO:0016020 cell adhesion molecule#PC00069 HUMAN|HGNC=22125|UniProtKB=O95522 O95522 PRAMEF12 PTHR14224:SF111 SIMILAR TO PREFERENTIALLY EXPRESSED ANTIGEN IN MELANOMA-LIKE 3 PRAME FAMILY MEMBER 12 enzyme-substrate adaptor activity#GO:0140767;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056 intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;ubiquitin ligase complex#GO:0000151;Cul2-RING ubiquitin ligase complex#GO:0031462;transferase complex#GO:1990234;catalytic complex#GO:1902494;cytoplasm#GO:0005737;cullin-RING ubiquitin ligase complex#GO:0031461;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 HUMAN|HGNC=13943|UniProtKB=Q99946 Q99946 PRRT1 PTHR14948:SF21 NG5 PROLINE-RICH TRANSMEMBRANE PROTEIN 1 molecular function regulator activity#GO:0098772;signaling receptor regulator activity#GO:0030545 cell junction organization#GO:0034330;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;synapse organization#GO:0050808;cellular component organization#GO:0016043 cell junction#GO:0030054;postsynaptic membrane#GO:0045211;synaptic membrane#GO:0097060;plasma membrane region#GO:0098590;glutamatergic synapse#GO:0098978;cellular anatomical structure#GO:0110165;synapse#GO:0045202;plasma membrane#GO:0005886;postsynapse#GO:0098794;membrane#GO:0016020;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HUMAN|HGNC=12703|UniProtKB=O76090 O76090 BEST1 PTHR10736:SF4 BESTROPHIN BESTROPHIN-1 monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic anion transmembrane transporter activity#GO:0008509;passive transmembrane transporter activity#GO:0022803;chloride transmembrane transporter activity#GO:0015108;chloride channel activity#GO:0005254;channel activity#GO:0015267;monoatomic anion channel activity#GO:0005253 monoatomic anion transport#GO:0006820;cellular process#GO:0009987;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220;chloride transport#GO:0006821;transport#GO:0006810;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;chloride transmembrane transport#GO:1902476;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=37294|UniProtKB=P0CG41 P0CG41 CTAGE8 PTHR23158:SF57 MELANOMA INHIBITORY ACTIVITY-RELATED CTAGE FAMILY MEMBER 15-RELATED protein localization to extracellular region#GO:0071692;export from cell#GO:0140352;protein transport#GO:0015031;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;secretion by cell#GO:0032940;cellular localization#GO:0051641;secretion#GO:0046903;localization#GO:0051179;protein secretion#GO:0009306;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;macromolecule localization#GO:0033036;vesicle-mediated transport#GO:0016192;Golgi vesicle transport#GO:0048193;transport#GO:0006810;intracellular transport#GO:0046907;establishment of protein localization to extracellular region#GO:0035592;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234 organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum exit site#GO:0070971;endoplasmic reticulum#GO:0005783;endomembrane system#GO:0012505;cytoplasm#GO:0005737;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 membrane traffic protein#PC00150 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HUMAN|HGNC=18263|UniProtKB=Q9UL25 Q9UL25 RAB21 PTHR24073:SF1235 DRAB5-RELATED RAS-RELATED PROTEIN RAB-21 ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462 transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;protein transport#GO:0015031;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;macromolecule localization#GO:0033036 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 small GTPase#PC00208;G-protein#PC00020 HUMAN|HGNC=6940|UniProtKB=P10911 P10911 MCF2 PTHR22826:SF146 RHO GUANINE EXCHANGE FACTOR-RELATED PROTO-ONCOGENE DBL guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695 neuron development#GO:0048666;system development#GO:0048731;anatomical structure development#GO:0048856;dendrite development#GO:0016358;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cellular component organization#GO:0016043;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;developmental process#GO:0032502;neuron differentiation#GO:0030182;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;multicellular organismal process#GO:0032501;cellular process#GO:0009987;neuron projection development#GO:0031175 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 guanyl-nucleotide exchange factor#PC00113;protein-binding activity modulator#PC00095 HUMAN|HGNC=19322|UniProtKB=Q8WY54 Q8WY54 PPM1E PTHR13832:SF535 PROTEIN PHOSPHATASE 2C PROTEIN PHOSPHATASE 1E phosphoprotein phosphatase activity#GO:0004721;protein serine/threonine phosphatase activity#GO:0004722;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824 biological regulation#GO:0065007;regulation of actin cytoskeleton organization#GO:0032956;positive regulation of cellular component biogenesis#GO:0044089;signal transduction#GO:0007165;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of actin filament organization#GO:0110053;cellular process#GO:0009987;positive regulation of actin filament bundle assembly#GO:0032233;regulation of actin filament-based process#GO:0032970;signaling#GO:0023052;regulation of cellular component biogenesis#GO:0044087;regulation of stress fiber assembly#GO:0051492;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of supramolecular fiber organization#GO:1902903;cellular response to stimulus#GO:0051716;regulation of organelle organization#GO:0033043;regulation of actin filament bundle assembly#GO:0032231;cell communication#GO:0007154;positive regulation of organelle organization#GO:0010638;positive regulation of cellular component organization#GO:0051130 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 protein phosphatase#PC00195 HUMAN|HGNC=25662|UniProtKB=Q6PD74 Q6PD74 AAGAB PTHR14659:SF1 ALPHA- AND GAMMA-ADAPTIN-BINDING PROTEIN P34 ALPHA- AND GAMMA-ADAPTIN-BINDING PROTEIN P34 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=8014|UniProtKB=P67809 P67809 YBX1 PTHR11544:SF143 COLD SHOCK DOMAIN CONTAINING PROTEINS Y-BOX-BINDING PROTEIN 1 nucleic acid binding#GO:0003676;binding#GO:0005488 biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=1062|UniProtKB=P53004 P53004 BLVRA PTHR43377:SF13 BILIVERDIN REDUCTASE A BILIVERDIN REDUCTASE A catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;oxidoreductase activity#GO:0016491 dehydrogenase#PC00092 HUMAN|HGNC=43638|UniProtKB=A8MW99 A8MW99 MEI4 PTHR28575:SF1 MEIOSIS-SPECIFIC PROTEIN MEI4 MEIOSIS-SPECIFIC PROTEIN MEI4 nuclear division#GO:0000280;cell development#GO:0048468;cellular process involved in reproduction in multicellular organism#GO:0022412;cell differentiation#GO:0030154;gamete generation#GO:0007276;cell cycle process#GO:0022402;meiosis I#GO:0007127;meiotic cell cycle process#GO:1903046;nuclear chromosome segregation#GO:0098813;cellular component organization#GO:0016043;cellular component organization or biogenesis#GO:0071840;homologous chromosome segregation#GO:0045143;chromosome segregation#GO:0007059;meiotic cell cycle#GO:0051321;chromosome organization involved in meiotic cell cycle#GO:0070192;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;oogenesis#GO:0048477;homologous chromosome pairing at meiosis#GO:0007129;cellular process#GO:0009987;organelle organization#GO:0006996;meiotic DNA double-strand break formation#GO:0042138;multicellular organismal reproductive process#GO:0048609;anatomical structure development#GO:0048856;organelle fission#GO:0048285;sexual reproduction#GO:0019953;meiosis I cell cycle process#GO:0061982;reproductive process#GO:0022414;germ cell development#GO:0007281;cell cycle#GO:0007049;developmental process involved in reproduction#GO:0003006;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;chromosome organization#GO:0051276;meiotic chromosome segregation#GO:0045132;macromolecule metabolic process#GO:0043170;meiotic nuclear division#GO:0140013;cellular developmental process#GO:0048869;spermatogenesis#GO:0007283;developmental process#GO:0032502;nucleobase-containing compound metabolic process#GO:0006139;male gamete generation#GO:0048232 membraneless organelle#GO:0043228;synaptonemal complex#GO:0000795;condensed nuclear chromosome#GO:0000794;condensed chromosome#GO:0000793;synaptonemal structure#GO:0099086;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;chromosome#GO:0005694 HUMAN|HGNC=9972|UniProtKB=P35249 P35249 RFC4 PTHR11669:SF20 REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT REPLICATION FACTOR C SUBUNIT 4 catalytic activity, acting on DNA#GO:0140097;ATP-dependent activity, acting on DNA#GO:0008094;ATP-dependent activity#GO:0140657;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;DNA replication#GO:0006260;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;DNA-templated DNA replication#GO:0006261;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA damage response#GO:0006974;cellular response to stress#GO:0033554 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;replication fork#GO:0005657;chromosome#GO:0005694 DNA-directed DNA polymerase#PC00018 DNA replication#P00017>RFC#P00529 HUMAN|HGNC=19905|UniProtKB=Q96PU9 Q96PU9 CIMAP1A PTHR21580:SF23 SHIPPO-1-RELATED CILIARY MICROTUBULE ASSOCIATED PROTEIN 1A cilium movement involved in cell motility#GO:0060294;sperm motility#GO:0097722;cellular process#GO:0009987;microtubule-based movement#GO:0007018;cell motility#GO:0048870;reproductive process#GO:0022414;flagellated sperm motility#GO:0030317;cilium or flagellum-dependent cell motility#GO:0001539;cilium movement#GO:0003341;cilium-dependent cell motility#GO:0060285;microtubule-based process#GO:0007017 sperm flagellum#GO:0036126;cellular anatomical structure#GO:0110165;organelle#GO:0043226;motile cilium#GO:0031514;plasma membrane bounded cell projection#GO:0120025;intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;cytoskeleton#GO:0005856;cilium#GO:0005929;intracellular organelle#GO:0043229;9+2 motile cilium#GO:0097729;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 structural protein#PC00211 HUMAN|HGNC=44197|UniProtKB=F5H4B4 F5H4B4 FAM227A PTHR33560:SF1 PROTEIN FAM227B PROTEIN FAM227A HUMAN|HGNC=10011|UniProtKB=Q15382 Q15382 RHEB PTHR24070:SF264 RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY GTP-BINDING PROTEIN RHEB protein kinase activator activity#GO:0030295;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;molecular function regulator activity#GO:0098772;GTPase activity#GO:0003924;kinase activator activity#GO:0019209;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;enzyme activator activity#GO:0008047;protein serine/threonine kinase activator activity#GO:0043539;protein kinase regulator activity#GO:0019887;kinase regulator activity#GO:0019207;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;signaling#GO:0023052;regulation of cell communication#GO:0010646;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;positive regulation of signaling#GO:0023056;positive regulation of TOR signaling#GO:0032008;intracellular signal transduction#GO:0035556;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;positive regulation of response to stimulus#GO:0048584;regulation of signal transduction#GO:0009966;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124;positive regulation of TORC1 signaling#GO:1904263;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of TOR signaling#GO:0032006;cellular process#GO:0009987;regulation of TORC1 signaling#GO:1903432;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 small GTPase#PC00208 CCKR signaling map#P06959>RHEB-GTP#P07224;CCKR signaling map#P06959>RHEB-GDP#P07175;p53 pathway by glucose deprivation#P04397>Rheb#P04642 HUMAN|HGNC=11244|UniProtKB=P00995 P00995 SPINK1 PTHR21312:SF27 SERINE PROTEASE INHIBITOR SERINE PROTEASE INHIBITOR KAZAL-TYPE 1 protease inhibitor#PC00191;protein-binding activity modulator#PC00095 HUMAN|HGNC=15930|UniProtKB=Q9NR83 Q9NR83 SLC2A4RG PTHR13006:SF8 PAPILLOMAVIRUS REGULATORY FACTOR PRF-1 SLC2A4 REGULATOR double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 transcription cofactor#PC00217 HUMAN|HGNC=10769|UniProtKB=Q13435 Q13435 SF3B2 PTHR12785:SF19 SPLICING FACTOR 3B SPLICING FACTOR 3B SUBUNIT 2 mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380 U2 snRNP#GO:0005686;catalytic step 2 spliceosome#GO:0071013;Sm-like protein family complex#GO:0120114;U12-type spliceosomal complex#GO:0005689;nuclear protein-containing complex#GO:0140513;small nuclear ribonucleoprotein complex#GO:0030532;nucleus#GO:0005634;protein-containing complex#GO:0032991;precatalytic spliceosome#GO:0071011;ribonucleoprotein complex#GO:1990904;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;spliceosomal snRNP complex#GO:0097525;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;spliceosomal complex#GO:0005681;cellular anatomical structure#GO:0110165;organelle#GO:0043226;U2-type spliceosomal complex#GO:0005684;intracellular membrane-bounded organelle#GO:0043231 RNA processing factor#PC00147;RNA splicing factor#PC00148 HUMAN|HGNC=30308|UniProtKB=Q96B86 Q96B86 RGMA PTHR31428:SF4 RGM DOMAIN FAMILY MEMBER DRAG-1 REPULSIVE GUIDANCE MOLECULE A molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;coreceptor activity#GO:0015026 cellular response to growth factor stimulus#GO:0071363;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;BMP signaling pathway#GO:0030509;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;response to growth factor#GO:0070848;cell surface receptor signaling pathway#GO:0007166;cellular response to BMP stimulus#GO:0071773;response to BMP#GO:0071772;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;cellular process#GO:0009987;signal transduction#GO:0007165;biological regulation#GO:0065007;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=17719|UniProtKB=Q9NRR8 Q9NRR8 CDC42SE1 PTHR13502:SF3 CDC42 SMALL EFFECTOR PROTEIN HOMOLOG CDC42 SMALL EFFECTOR PROTEIN 1 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 HUMAN|HGNC=18652|UniProtKB=Q9P1Q0 Q9P1Q0 VPS54 PTHR12965:SF0 VACUOLAR PROTEIN SORTING 54 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 54 binding#GO:0005488;SNARE binding#GO:0000149;protein binding#GO:0005515;syntaxin binding#GO:0019905 vesicle-mediated transport#GO:0016192;endocytic recycling#GO:0032456;cytosolic transport#GO:0016482;retrograde transport, endosome to Golgi#GO:0042147;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;endosomal transport#GO:0016197;vesicle-mediated transport to the plasma membrane#GO:0098876;intracellular transport#GO:0046907;transport#GO:0006810;localization within membrane#GO:0051668 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;vesicle tethering complex#GO:0099023;vesicle#GO:0031982;intracellular vesicle#GO:0097708;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;organelle#GO:0043226 membrane traffic protein#PC00150 HUMAN|HGNC=26133|UniProtKB=Q9H720 Q9H720 CWH43 PTHR14859:SF1 CALCOFLUOR WHITE HYPERSENSITIVE PROTEIN PRECURSOR PGAP2-INTERACTING PROTEIN GPI anchor biosynthetic process#GO:0006506;glycerophospholipid metabolic process#GO:0006650;protein maturation#GO:0051604;lipid biosynthetic process#GO:0008610;gene expression#GO:0010467;biosynthetic process#GO:0009058;organophosphate metabolic process#GO:0019637;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;glycerolipid biosynthetic process#GO:0045017;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;metabolic process#GO:0008152;glycerophospholipid biosynthetic process#GO:0046474;GPI anchor metabolic process#GO:0006505;lipid metabolic process#GO:0006629;liposaccharide metabolic process#GO:1903509;GPI anchored protein biosynthesis#GO:0180046;glycerolipid metabolic process#GO:0046486;phospholipid biosynthetic process#GO:0008654;glycolipid metabolic process#GO:0006664;phospholipid metabolic process#GO:0006644;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;glycolipid biosynthetic process#GO:0009247;protein metabolic process#GO:0019538;organophosphate biosynthetic process#GO:0090407 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=14299|UniProtKB=Q9H228 Q9H228 S1PR5 PTHR22750:SF20 G-PROTEIN COUPLED RECEPTOR SPHINGOSINE 1-PHOSPHATE RECEPTOR 5 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930 cell communication#GO:0007154;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021 HUMAN|HGNC=26847|UniProtKB=Q8N815 Q8N815 CNTD1 PTHR21615:SF2 CYCLIN N-TERMINAL DOMAIN-CONTAINING PROTEIN 1 CYCLIN N-TERMINAL DOMAIN-CONTAINING PROTEIN 1 Cell cycle#P00013>Proteasome#P00480 HUMAN|HGNC=9385|UniProtKB=P54619 P54619 PRKAG1 PTHR13780:SF38 AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1 protein binding#GO:0005515;enzyme regulator activity#GO:0030234;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;nucleoside phosphate binding#GO:1901265;kinase binding#GO:0019900;binding#GO:0005488;kinase regulator activity#GO:0019207;protein kinase regulator activity#GO:0019887;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;cation binding#GO:0043169;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;nucleotide binding#GO:0000166;molecular function regulator activity#GO:0098772 biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;cellular response to glucose starvation#GO:0042149;regulation of primary metabolic process#GO:0080090;response to nutrient levels#GO:0031667;regulation of metabolic process#GO:0019222;response to stress#GO:0006950;regulation of catabolic process#GO:0009894;regulation of biosynthetic process#GO:0009889;cellular response to nutrient levels#GO:0031669;cellular response to starvation#GO:0009267;regulation of carbohydrate metabolic process#GO:0006109;regulation of carbohydrate biosynthetic process#GO:0043255;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to starvation#GO:0042594;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;cellular response to stress#GO:0033554 protein kinase complex#GO:1902911;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex#GO:1990234;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634 kinase modulator#PC00140 Gonadotropin-releasing hormone receptor pathway#P06664>AMPK#P06830;p53 pathway by glucose deprivation#P04397>AMPK#P04639 HUMAN|HGNC=4084|UniProtKB=O14764 O14764 GABRD PTHR18945:SF34 NEUROTRANSMITTER GATED ION CHANNEL GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT DELTA extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;signaling receptor activity#GO:0038023;chloride channel activity#GO:0005254;neurotransmitter receptor activity#GO:0030594;monoatomic anion transmembrane transporter activity#GO:0008509;transporter activity#GO:0005215;transmembrane signaling receptor activity#GO:0004888;gated channel activity#GO:0022836;passive transmembrane transporter activity#GO:0022803;chloride transmembrane transporter activity#GO:0015108;ligand-gated channel activity#GO:0022834;transmembrane transporter activity#GO:0022857;molecular transducer activity#GO:0060089;monoatomic anion channel activity#GO:0005253;channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276 chloride transport#GO:0006821;transport#GO:0006810;establishment of localization#GO:0051234;synaptic signaling#GO:0099536;cellular process#GO:0009987;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;trans-synaptic signaling#GO:0099537;transmembrane transport#GO:0055085;cell communication#GO:0007154;localization#GO:0051179;chloride transmembrane transport#GO:1902476;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698;chemical synaptic transmission#GO:0007268;monoatomic anion transport#GO:0006820;regulation of biological process#GO:0050789;anterograde trans-synaptic signaling#GO:0098916;signaling#GO:0023052 protein-containing complex#GO:0032991;synapse#GO:0045202;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;GABA-ergic synapse#GO:0098982;membrane#GO:0016020;cell periphery#GO:0071944;cell junction#GO:0030054;signaling receptor complex#GO:0043235 ligand-gated ion channel#PC00141 HUMAN|HGNC=6093|UniProtKB=P14616 P14616 INSRR PTHR24416:SF338 TYROSINE-PROTEIN KINASE RECEPTOR INSULIN RECEPTOR-RELATED PROTEIN phosphotransferase activity, alcohol group as acceptor#GO:0016773;molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888;catalytic activity, acting on a protein#GO:0140096;signaling receptor activity#GO:0038023;transmembrane receptor protein kinase activity#GO:0019199;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;homeostatic process#GO:0042592;cellular response to peptide hormone stimulus#GO:0071375;regulation of cell communication#GO:0010646;positive regulation of signal transduction#GO:0009967;response to insulin#GO:0032868;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;response to nitrogen compound#GO:1901698;regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051896;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of response to stimulus#GO:0048584;cellular response to nitrogen compound#GO:1901699;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;response to peptide hormone#GO:0043434;positive regulation of cellular process#GO:0048522;positive regulation of MAPK cascade#GO:0043410;positive regulation of intracellular signal transduction#GO:1902533;cellular response to insulin stimulus#GO:0032869;regulation of response to stimulus#GO:0048583;insulin-like growth factor receptor signaling pathway#GO:0048009;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051897;cellular response to hormone stimulus#GO:0032870;signaling#GO:0023052;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;carbohydrate homeostasis#GO:0033500;positive regulation of signaling#GO:0023056;cellular response to chemical stimulus#GO:0070887;regulation of intracellular signal transduction#GO:1902531;response to oxygen-containing compound#GO:1901700;insulin receptor signaling pathway#GO:0008286;regulation of signaling#GO:0023051;response to chemical#GO:0042221;response to hormone#GO:0009725;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987;regulation of JNK cascade#GO:0046328;glucose homeostasis#GO:0042593;regulation of MAPK cascade#GO:0043408;cell surface receptor signaling pathway#GO:0007166;chemical homeostasis#GO:0048878 plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cell periphery#GO:0071944;neuron projection#GO:0043005;membrane#GO:0016020;protein kinase complex#GO:1902911;signaling receptor complex#GO:0043235;transferase complex#GO:1990234;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;axon#GO:0030424;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695 transmembrane signal receptor#PC00197 Insulin/IGF pathway-protein kinase B signaling cascade#P00033>INSR IGF-R IRR#P00895;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>Insulin IGF#P00882;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>INSR IGF-R IRR#P00885 HUMAN|HGNC=26992|UniProtKB=Q8IVW8 Q8IVW8 SPNS2 PTHR23505:SF4 SPINSTER SPHINGOSINE-1-PHOSPHATE TRANSPORTER SPNS2 molecular carrier activity#GO:0140104;lipid carrier activity#GO:0005319;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;intramembrane lipid carrier activity#GO:0140303 cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;lipid localization#GO:0010876;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;localization#GO:0051179;macromolecule localization#GO:0033036;cellular process#GO:0009987;signal transduction#GO:0007165;lipid transport#GO:0006869;biological regulation#GO:0065007;transport#GO:0006810;establishment of localization#GO:0051234 membrane#GO:0016020;cellular anatomical structure#GO:0110165 transporter#PC00227 HUMAN|HGNC=21628|UniProtKB=Q14592 Q14592 ZNF460 PTHR24384:SF15 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED ZINC FINGER PROTEIN 460 transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218 HUMAN|HGNC=7108|UniProtKB=Q9NPJ1 Q9NPJ1 MKKS PTHR46787:SF1 SYNDROMES PUTATIVE CHAPERONIN-RELATED MOLECULAR CHAPERONE MKKS cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;plasma membrane bounded cell projection assembly#GO:0120031;cell projection organization#GO:0030030;cellular component organization#GO:0016043;cilium assembly#GO:0060271;protein-containing complex assembly#GO:0065003;cilium organization#GO:0044782;organelle assembly#GO:0070925;chaperone-mediated protein complex assembly#GO:0051131 cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;cell projection#GO:0042995;intracellular anatomical structure#GO:0005622;non-motile cilium#GO:0097730;membrane-bounded organelle#GO:0043227;cluster of actin-based cell projections#GO:0098862;cilium#GO:0005929;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;nucleus#GO:0005634;neuron projection#GO:0043005;membraneless organelle#GO:0043228;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815 chaperone#PC00072 HUMAN|HGNC=16923|UniProtKB=Q96P47 Q96P47 AGAP3 PTHR45819:SF2 CENTAURIN-GAMMA-1A ARF-GAP WITH GTPASE, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 3 GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;ribonucleoside triphosphate phosphatase activity#GO:0017111;molecular function regulator activity#GO:0098772;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;enzyme activator activity#GO:0008047;hydrolase activity, acting on acid anhydrides#GO:0016817;enzyme regulator activity#GO:0030234;hydrolase activity#GO:0016787;molecular function activator activity#GO:0140677;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924 ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 GTPase-activating protein#PC00257;G-protein modulator#PC00022 HUMAN|HGNC=10697|UniProtKB=P55735 P55735 SEC13 PTHR11024:SF21 NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER PROTEIN SEC13 HOMOLOG vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;regulation of TOR signaling#GO:0032006;positive regulation of biological process#GO:0048518;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;organelle organization#GO:0006996;vesicle organization#GO:0016050;cellular component organization or biogenesis#GO:0071840;Golgi vesicle transport#GO:0048193;intracellular protein transport#GO:0006886;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;protein transport#GO:0015031;protein import into nucleus#GO:0006606;positive regulation of signaling#GO:0023056;cellular localization#GO:0051641;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;regulation of signal transduction#GO:0009966;membrane organization#GO:0061024;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;positive regulation of cellular process#GO:0048522;protein localization to nucleus#GO:0034504;macromolecule localization#GO:0033036;import into nucleus#GO:0051170;vesicle budding from membrane#GO:0006900;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;transport#GO:0006810;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;intracellular transport#GO:0046907;regulation of cell communication#GO:0010646;protein localization to organelle#GO:0033365;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;positive regulation of signal transduction#GO:0009967;positive regulation of TOR signaling#GO:0032008;nuclear transport#GO:0051169;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;localization#GO:0051179;COPII-coated vesicle budding#GO:0090114;nucleocytoplasmic transport#GO:0006913 intracellular vesicle#GO:0097708;coated vesicle membrane#GO:0030662;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;coated vesicle#GO:0030135;coated membrane#GO:0048475;vesicle coat#GO:0030120;nuclear envelope#GO:0005635;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;nuclear pore#GO:0005643;bounding membrane of organelle#GO:0098588;nuclear protein-containing complex#GO:0140513;vesicle#GO:0031982;nuclear pore outer ring#GO:0031080;organelle envelope#GO:0031967;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane coat#GO:0030117;COPII-coated ER to Golgi transport vesicle#GO:0030134;nucleus#GO:0005634;vesicle membrane#GO:0012506;membrane#GO:0016020;transport vesicle#GO:0030133;endomembrane system#GO:0012505;transport vesicle membrane#GO:0030658;ER to Golgi transport vesicle membrane#GO:0012507;organelle membrane#GO:0031090 transporter#PC00227 HUMAN|HGNC=26536|UniProtKB=Q8NEE8 Q8NEE8 TTC16 PTHR45153:SF1 TETRATRICOPEPTIDE REPEAT PROTEIN 16 TETRATRICOPEPTIDE REPEAT PROTEIN 16 HUMAN|HGNC=5475|UniProtKB=P24592 P24592 IGFBP6 PTHR11551:SF14 INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 6 binding#GO:0005488;growth factor binding#GO:0019838;protein binding#GO:0005515 regulation of biological process#GO:0050789;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191;protein-binding activity modulator#PC00095 HUMAN|HGNC=11476|UniProtKB=O15260 O15260 SURF4 PTHR23427:SF13 SURFEIT LOCUS PROTEIN SURFEIT LOCUS PROTEIN 4 cellular component organization or biogenesis#GO:0071840;endomembrane system organization#GO:0010256;organelle organization#GO:0006996;cellular component organization#GO:0016043;Golgi organization#GO:0007030;cellular process#GO:0009987 endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 chaperone#PC00072 HUMAN|HGNC=53637|UniProtKB=A0A1B0GTH6 A0A1B0GTH6 CSNK2A2IP PTHR35825:SF2 CASEIN KINASE II SUBUNIT ALPHA PRIME-INTERACTING PROTEIN CASEIN KINASE II SUBUNIT ALPHA'-INTERACTING PROTEIN HUMAN|HGNC=24043|UniProtKB=Q15847 Q15847 ADIRF PTHR39227:SF1 ADIPOGENESIS REGULATORY FACTOR ADIPOGENESIS REGULATORY FACTOR regulation of RNA metabolic process#GO:0051252;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;positive regulation of fat cell differentiation#GO:0045600;regulation of developmental process#GO:0050793;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of developmental process#GO:0051094;regulation of cell differentiation#GO:0045595;positive regulation of cell differentiation#GO:0045597;positive regulation of transcription by RNA polymerase II#GO:0045944;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=27271|UniProtKB=P0CG24 P0CG24 ZNF883 PTHR23226:SF317 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER PROTEIN 883 RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=14466|UniProtKB=Q9ULP0 Q9ULP0 NDRG4 PTHR11034:SF21 N-MYC DOWNSTREAM REGULATED PROTEIN NDRG4 regulation of response to stimulus#GO:0048583;regulation of MAPK cascade#GO:0043408;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of MAPK cascade#GO:0043410;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;regulation of ERK1 and ERK2 cascade#GO:0070372;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;positive regulation of signaling#GO:0023056;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;positive regulation of ERK1 and ERK2 cascade#GO:0070374;regulation of cell communication#GO:0010646;signaling#GO:0023052;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;response to stimulus#GO:0050896 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 serine protease#PC00203 HUMAN|HGNC=37215|UniProtKB=A6NIK2 A6NIK2 LRRC10B PTHR16083:SF6 LEUCINE RICH REPEAT CONTAINING PROTEIN LEUCINE-RICH REPEAT-CONTAINING PROTEIN 10B scaffold/adaptor protein#PC00226 HUMAN|HGNC=29104|UniProtKB=O94819 O94819 KBTBD11 PTHR45972:SF3 BTB_2 DOMAIN-CONTAINING PROTEIN KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 11 HUMAN|HGNC=25544|UniProtKB=Q9HCI7 Q9HCI7 MSL2 PTHR16048:SF3 MSL2-RELATED E3 UBIQUITIN-PROTEIN LIGASE MSL2 ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule metabolic process#GO:0043170;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;cellular process#GO:0009987;protein modification process#GO:0036211;primary metabolic process#GO:0044238 protein acetyltransferase complex#GO:0031248;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;acetyltransferase complex#GO:1902493;chromosome#GO:0005694;cellular anatomical structure#GO:0110165;organelle#GO:0043226;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;histone acetyltransferase complex#GO:0000123;membraneless organelle#GO:0043228;chromatin#GO:0000785;intracellular membraneless organelle#GO:0043232;H4 histone acetyltransferase complex#GO:1902562;protein-containing complex#GO:0032991 HUMAN|HGNC=18468|UniProtKB=Q9NQE9 Q9NQE9 HINT3 PTHR12486:SF5 APRATAXIN-RELATED ADENOSINE 5'-MONOPHOSPHORAMIDASE HINT3 damaged DNA-binding protein#PC00086;DNA metabolism protein#PC00009 HUMAN|HGNC=25335|UniProtKB=Q8ND24 Q8ND24 RNF214 PTHR15727:SF3 RING FINGER PROTEIN 214 RING FINGER PROTEIN 214 ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;ubiquitin-protein transferase activity#GO:0004842;catalytic activity, acting on a protein#GO:0140096 HUMAN|HGNC=21785|UniProtKB=Q5RL73 Q5RL73 RBM48 PTHR20957:SF1 RNA-BINDING PROTEIN 48 RNA-BINDING PROTEIN 48 RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139 nuclear protein-containing complex#GO:0140513;U12-type spliceosomal complex#GO:0005689;catalytic step 2 spliceosome#GO:0071013;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;spliceosomal complex#GO:0005681;organelle lumen#GO:0043233;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=21698|UniProtKB=Q9NWF9 Q9NWF9 RNF216 PTHR22770:SF47 UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED E3 UBIQUITIN-PROTEIN LIGASE RNF216 transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659 proteasomal protein catabolic process#GO:0010498;biological regulation#GO:0065007;cellular process#GO:0009987;ubiquitin-dependent protein catabolic process#GO:0006511;regulation of localization#GO:0032879;regulation of transport#GO:0051049;macromolecule metabolic process#GO:0043170;regulation of endocytosis#GO:0030100;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of receptor-mediated endocytosis#GO:0048259;regulation of cellular component organization#GO:0051128;regulation of biological process#GO:0050789;modification-dependent protein catabolic process#GO:0019941;regulation of vesicle-mediated transport#GO:0060627;primary metabolic process#GO:0044238;regulation of biological quality#GO:0065008;protein metabolic process#GO:0019538;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163 intracellular protein-containing complex#GO:0140535;ubiquitin ligase complex#GO:0000151;cell junction#GO:0030054;transferase complex#GO:1990234;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;synapse#GO:0045202;cellular anatomical structure#GO:0110165;presynapse#GO:0098793;postsynapse#GO:0098794 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=18628|UniProtKB=Q9NY15 Q9NY15 STAB1 PTHR24038:SF8 STABILIN STABILIN-1 membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=12710|UniProtKB=Q9UKI3 Q9UKI3 VPREB3 PTHR23267:SF133 IMMUNOGLOBULIN LIGHT CHAIN PRE-B LYMPHOCYTE PROTEIN 3 response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=28498|UniProtKB=Q8TAG6 Q8TAG6 VXN PTHR31520:SF1 VEXIN VEXIN nervous system development#GO:0007399;cell differentiation#GO:0030154;multicellular organismal process#GO:0032501;cellular process#GO:0009987;system development#GO:0048731;neurogenesis#GO:0022008;multicellular organism development#GO:0007275;anatomical structure development#GO:0048856;cellular developmental process#GO:0048869;neuron differentiation#GO:0030182;generation of neurons#GO:0048699;developmental process#GO:0032502;animal gross anatomical part developmental process#GO:0160108 HUMAN|HGNC=7988|UniProtKB=Q86VF7 Q86VF7 NRAP PTHR11039:SF39 NEBULIN NEBULIN-RELATED-ANCHORING PROTEIN protein-containing complex binding#GO:0044877;protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;actin filament binding#GO:0051015;actin binding#GO:0003779;binding#GO:0005488 striated muscle cell development#GO:0055002;animal gross anatomical part developmental process#GO:0160108;actomyosin structure organization#GO:0031032;cell development#GO:0048468;cell differentiation#GO:0030154;circulatory system development#GO:0072359;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;anatomical structure formation involved in morphogenesis#GO:0048646;striated muscle cell differentiation#GO:0051146;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;animal organ development#GO:0048513;striated muscle tissue development#GO:0014706;cellular anatomical entity morphogenesis#GO:0032989;cytoskeleton organization#GO:0007010;cardiac muscle cell differentiation#GO:0055007;cellular component assembly#GO:0022607;heart development#GO:0007507;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;muscle tissue development#GO:0060537;supramolecular fiber organization#GO:0097435;system development#GO:0048731;anatomical structure development#GO:0048856;actin filament-based process#GO:0030029;organelle assembly#GO:0070925;cellular component assembly involved in morphogenesis#GO:0010927;actin cytoskeleton organization#GO:0030036;muscle structure development#GO:0061061;myofibril assembly#GO:0030239;muscle cell differentiation#GO:0042692;muscle cell development#GO:0055001;actin filament organization#GO:0007015;cardiac muscle tissue development#GO:0048738;cellular developmental process#GO:0048869;developmental process#GO:0032502;multicellular organismal process#GO:0032501;tissue development#GO:0009888 intracellular organelle#GO:0043229;I band#GO:0031674;sarcomere#GO:0030017;membraneless organelle#GO:0043228;myofibril#GO:0030016;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;contractile muscle fiber#GO:0043292;Z disc#GO:0030018;supramolecular complex#GO:0099080;organelle#GO:0043226;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737 HUMAN|HGNC=3942|UniProtKB=P42345 P42345 MTOR PTHR11139:SF134 ATAXIA TELANGIECTASIA MUTATED ATM -RELATED SERINE_THREONINE-PROTEIN KINASE MTOR protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096 regulation of macroautophagy#GO:0016241;negative regulation of autophagy#GO:0010507;regulation of catabolic process#GO:0009894;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;TOR signaling#GO:0031929;regulation of metabolic process#GO:0019222;negative regulation of macroautophagy#GO:0016242;signal transduction#GO:0007165;cellular process#GO:0009987;TORC1 signaling#GO:0038202;cell communication#GO:0007154;negative regulation of catabolic process#GO:0009895;intracellular signal transduction#GO:0035556;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;signaling#GO:0023052;negative regulation of biological process#GO:0048519;regulation of autophagy#GO:0010506;TORC2 signaling#GO:0038203;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716 intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;TOR complex#GO:0038201;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 p53 pathway by glucose deprivation#P04397>mTOR#P04638;PDGF signaling pathway#P00047>mTOR#P01144;Interleukin signaling pathway#P00036>mTOR#P00966;Hypoxia response via HIF activation#P00030>TOR#P00817 HUMAN|HGNC=8752|UniProtKB=Q9UKL6 Q9UKL6 PCTP PTHR19308:SF59 PHOSPHATIDYLCHOLINE TRANSFER PROTEIN PHOSPHATIDYLCHOLINE TRANSFER PROTEIN phosphatidylcholine binding#GO:0031210;transporter activity#GO:0005215;phospholipid binding#GO:0005543;cation binding#GO:0043169;lipid binding#GO:0008289;intramembrane lipid carrier activity#GO:0140303;lipid carrier activity#GO:0005319;phosphatidylcholine intramembrane carrier activity#GO:0008525;ion binding#GO:0043167;molecular carrier activity#GO:0140104;small molecule binding#GO:0036094;binding#GO:0005488 HUMAN|HGNC=25786|UniProtKB=Q9H902 Q9H902 REEP1 PTHR12300:SF33 HVA22-LIKE PROTEINS RECEPTOR EXPRESSION-ENHANCING PROTEIN 1 protein binding#GO:0005515;G protein-coupled receptor binding#GO:0001664;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;signaling receptor binding#GO:0005102;binding#GO:0005488;microtubule binding#GO:0008017 endomembrane system organization#GO:0010256;cellular component organization or biogenesis#GO:0071840;endoplasmic reticulum tubular network organization#GO:0071786;endoplasmic reticulum organization#GO:0007029;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996 organelle membrane#GO:0031090;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;endoplasmic reticulum#GO:0005783;cytoskeleton#GO:0005856;endoplasmic reticulum membrane#GO:0005789;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;endomembrane system#GO:0012505;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;endoplasmic reticulum tubular network#GO:0071782;membrane#GO:0016020;microtubule cytoskeleton#GO:0015630;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;supramolecular fiber#GO:0099512;microtubule#GO:0005874;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cytoplasmic microtubule#GO:0005881 membrane traffic protein#PC00150 HUMAN|HGNC=26923|UniProtKB=Q969V3 Q969V3 NCLN PTHR31826:SF8 NICALIN BOS COMPLEX SUBUNIT NCLN regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;regulation of biological process#GO:0050789;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051 endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;membrane#GO:0016020;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=3822|UniProtKB=A0A2Z4LIS9 A0A2Z4LIS9 FOXO3B PTHR45767:SF4 FORKHEAD BOX PROTEIN O FORKHEAD BOX PROTEIN O3-RELATED transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;response to nutrient levels#GO:0031667;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;response to stress#GO:0006950;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;response to starvation#GO:0042594;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;mitochondrion#GO:0005739;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 winged helix/forkhead transcription factor#PC00246 Insulin/IGF pathway-protein kinase B signaling cascade#P00033>FKHR#P00898;Interleukin signaling pathway#P00036>FKHRL1#P00994;PI3 kinase pathway#P00048>FOXO#P01198;CCKR signaling map#P06959>FOXO3#P07073 HUMAN|HGNC=44406|UniProtKB=A6NCC3 A6NCC3 GOLGA8O PTHR10881:SF62 GOLGIN SUBFAMILY A MEMBER-RELATED GOLGIN SUBFAMILY A CONSERVED DOMAIN-CONTAINING PROTEIN-RELATED organelle organization#GO:0006996;cellular component organization#GO:0016043;Golgi organization#GO:0007030;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;endomembrane system organization#GO:0010256 Golgi stack#GO:0005795;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;Golgi cisterna#GO:0031985;endomembrane system#GO:0012505;Golgi cis cisterna#GO:0000137;cytoplasm#GO:0005737;Golgi apparatus#GO:0005794;cis-Golgi network#GO:0005801;organelle membrane#GO:0031090 membrane traffic protein#PC00150 HUMAN|HGNC=6137|UniProtKB=P17301 P17301 ITGA2 PTHR23220:SF23 INTEGRIN ALPHA INTEGRIN ALPHA-2 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cell surface receptor signaling pathway#GO:0007166;cell-matrix adhesion#GO:0007160;cell adhesion#GO:0007155;cell-substrate adhesion#GO:0031589;cell communication#GO:0007154;integrin-mediated signaling pathway#GO:0007229;cell-cell adhesion#GO:0098609;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007 membrane#GO:0016020;membrane protein complex#GO:0098796;protein complex involved in cell adhesion#GO:0098636;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cell surface#GO:0009986;plasma membrane#GO:0005886;signaling receptor complex#GO:0043235;integrin complex#GO:0008305 cell adhesion molecule#PC00069;integrin#PC00126 Integrin signalling pathway#P00034>Integrin alpha#P00941;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>EMC#P00863 HUMAN|HGNC=18620|UniProtKB=Q9H9E3 Q9H9E3 COG4 PTHR24016:SF21 CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4 CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4 localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;transport#GO:0006810;Golgi vesicle transport#GO:0048193;endomembrane system organization#GO:0010256;vesicle-mediated transport#GO:0016192;Golgi organization#GO:0007030;intra-Golgi vesicle-mediated transport#GO:0006891;cellular process#GO:0009987;retrograde transport, vesicle recycling within Golgi#GO:0000301;organelle organization#GO:0006996;cellular component organization#GO:0016043 protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;COG complex#GO:0017119;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;vesicle tethering complex#GO:0099023 membrane traffic protein#PC00150 HUMAN|HGNC=23000|UniProtKB=Q7Z402 Q7Z402 TMC7 PTHR23302:SF42 TRANSMEMBRANE CHANNEL-RELATED TRANSMEMBRANE CHANNEL-LIKE PROTEIN 7 channel activity#GO:0015267;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;gated channel activity#GO:0022836;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;passive transmembrane transporter activity#GO:0022803 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133 HUMAN|HGNC=39004|UniProtKB=P10266 P10266 ERVK-10 PTHR41694:SF3 ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN ENDOGENOUS RETROVIRUS GROUP K MEMBER 10 POL PROTEIN-RELATED RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 viral or transposable element protein#PC00237 HUMAN|HGNC=14676|UniProtKB=Q9BYS8 Q9BYS8 LRRC2 PTHR45752:SF37 LEUCINE-RICH REPEAT-CONTAINING LEUCINE-RICH REPEAT-CONTAINING PROTEIN 2 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 scaffold/adaptor protein#PC00226 HUMAN|HGNC=8750|UniProtKB=Q00537 Q00537 CDK17 PTHR24056:SF128 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE 17 protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;cyclin-dependent protein serine/threonine kinase activity#GO:0004693;cyclin-dependent protein kinase activity#GO:0097472;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740 nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex#GO:1990234;protein kinase complex#GO:1902911;intracellular anatomical structure#GO:0005622;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=11869|UniProtKB=Q9UHN6 Q9UHN6 CEMIP2 PTHR15535:SF26 TRANSMEMBRANE PROTEIN 2-RELATED CELL SURFACE HYALURONIDASE CEMIP2 hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553 carbohydrate derivative catabolic process#GO:1901136;catabolic process#GO:0009056;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;glycosaminoglycan metabolic process#GO:0030203;macromolecule metabolic process#GO:0043170;aminoglycan catabolic process#GO:0006026;glycosaminoglycan catabolic process#GO:0006027;metabolic process#GO:0008152;aminoglycan metabolic process#GO:0006022;macromolecule catabolic process#GO:0009057 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=25374|UniProtKB=Q8N6S4 Q8N6S4 ANKRD13C PTHR12447:SF39 ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13 ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13C molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 regulation of receptor-mediated endocytosis#GO:0048259;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;regulation of localization#GO:0032879;regulation of transport#GO:0051049;regulation of endocytosis#GO:0030100 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768;late endosome#GO:0005770;endomembrane system#GO:0012505;plasma membrane#GO:0005886;cytoplasm#GO:0005737;membrane#GO:0016020;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HUMAN|HGNC=17920|UniProtKB=Q96C03 Q96C03 MIEF2 PTHR16451:SF11 MITOCHONDRIAL DYNAMICS PROTEINS 49/51 FAMILY MEMBER MITOCHONDRIAL DYNAMICS PROTEIN MID49 positive regulation of developmental process#GO:0051094;positive regulation of cellular component organization#GO:0051130;positive regulation of organelle organization#GO:0010638;regulation of anatomical structure morphogenesis#GO:0022603;regulation of organelle organization#GO:0033043;positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789;regulation of mitochondrion organization#GO:0010821;positive regulation of cellular process#GO:0048522;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of developmental process#GO:0050793;regulation of mitochondrial fission#GO:0090140;biological regulation#GO:0065007;positive regulation of mitochondrial fission#GO:0090141 intracellular organelle#GO:0043229;outer membrane#GO:0019867;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;mitochondrial outer membrane#GO:0005741;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;membrane#GO:0016020;cytoplasm#GO:0005737;organelle outer membrane#GO:0031968 HUMAN|HGNC=12855|UniProtKB=P63104 P63104 YWHAZ PTHR18860:SF7 14-3-3 PROTEIN 14-3-3 PROTEIN ZETA_DELTA scaffold/adaptor protein#PC00226 Parkinson disease#P00049>14-3-3#P01238;PI3 kinase pathway#P00048>14-3-3#P01206;EGF receptor signaling pathway#P00018>14-3-3#P00539;FGF signaling pathway#P00021>14-3-3#P00624 HUMAN|HGNC=24927|UniProtKB=O43745 O43745 CHP2 PTHR46002:SF6 EG:114D9.1 PROTEIN-RELATED CALCINEURIN B HOMOLOGOUS PROTEIN 2 cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167 positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of calcium-mediated signaling#GO:0050848;regulation of cell communication#GO:0010646;regulation of intracellular signal transduction#GO:1902531;positive regulation of calcium-mediated signaling#GO:0050850;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;regulation of calcineurin-NFAT signaling cascade#GO:0070884;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HUMAN|HGNC=32458|UniProtKB=A6NP11 A6NP11 ZNF716 PTHR24384:SF178 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED ZINC FINGER PROTEIN 716 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 DNA-binding transcription factor#PC00218 HUMAN|HGNC=20210|UniProtKB=Q9NWQ4 Q9NWQ4 GPATCH2L PTHR14195:SF3 G PATCH DOMAIN CONTAINING PROTEIN 2 G PATCH DOMAIN-CONTAINING PROTEIN 2-LIKE intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031 HUMAN|HGNC=3360|UniProtKB=O43768 O43768 ENSA PTHR10358:SF21 ENDOSULFINE ALPHA-ENDOSULFINE enzyme inhibitor activity#GO:0004857;protein phosphatase inhibitor activity#GO:0004864;molecular function regulator activity#GO:0098772;phosphatase inhibitor activity#GO:0019212;phosphatase regulator activity#GO:0019208;molecular function inhibitor activity#GO:0140678;protein phosphatase regulator activity#GO:0019888;enzyme regulator activity#GO:0030234 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=24017|UniProtKB=Q8N556 Q8N556 AFAP1 PTHR14338:SF8 ACTIN FILAMENT-ASSOCIATED PROTEIN 1 FAMILY MEMBER ACTIN FILAMENT-ASSOCIATED PROTEIN 1 regulation of biological process#GO:0050789;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cell communication#GO:0010646 intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;organelle#GO:0043226;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;cytosol#GO:0005829;actin cytoskeleton#GO:0015629;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;actin filament#GO:0005884;cytoskeleton#GO:0005856 HUMAN|HGNC=32423|UniProtKB=A6NNS2 A6NNS2 DHRS7C PTHR44668:SF2 FAMILY NOT NAMED DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 7C HUMAN|HGNC=12505|UniProtKB=P11441 P11441 UBL4A PTHR46555:SF1 UBIQUITIN-LIKE PROTEIN 4A UBIQUITIN-LIKE PROTEIN 4A HUMAN|HGNC=26762|UniProtKB=Q8N998 Q8N998 CCDC89 PTHR34768:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 89 COILED-COIL DOMAIN-CONTAINING PROTEIN 89 HUMAN|HGNC=9398|UniProtKB=Q13516 Q13516 OLIG2 PTHR19290:SF32 BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED OLIGODENDROCYTE TRANSCRIPTION FACTOR 2 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987 positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;cell projection organization#GO:0030030;cell development#GO:0048468;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;animal organ development#GO:0048513;positive regulation of transcription by RNA polymerase II#GO:0045944;neuron differentiation#GO:0030182;positive regulation of macromolecule metabolic process#GO:0010604;nervous system development#GO:0007399;neuron projection development#GO:0031175;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;sensory organ development#GO:0007423;developmental process#GO:0032502;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;positive regulation of DNA-templated transcription#GO:0045893;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;plasma membrane bounded cell projection organization#GO:0120036;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;axon development#GO:0061564;positive regulation of cellular process#GO:0048522 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=5835|UniProtKB=P06315 P06315 IGKV5-2 PTHR23267:SF313 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN KAPPA VARIABLE 5-2 response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=23287|UniProtKB=O95571 O95571 ETHE1 PTHR43084:SF1 PERSULFIDE DIOXYGENASE ETHE1 PERSULFIDE DIOXYGENASE ETHE1, MITOCHONDRIAL dioxygenase activity#GO:0051213;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen#GO:0016702;catalytic activity#GO:0003824 cellular process#GO:0009987;glutathione metabolic process#GO:0006749;modified amino acid metabolic process#GO:0006575;sulfur compound metabolic process#GO:0006790;metabolic process#GO:0008152 mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 oxidoreductase#PC00176;oxygenase#PC00177 HUMAN|HGNC=19653|UniProtKB=Q7RTT5 Q7RTT5 SSX7 PTHR14112:SF5 SYNOVIAL SARCOMA, X MEMBER PROTEIN SSX2-RELATED cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 transcription cofactor#PC00217;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=20968|UniProtKB=Q9H6W3 Q9H6W3 RIOX1 PTHR13096:SF8 MINA53 MYC INDUCED NUCLEAR ANTIGEN RIBOSOMAL OXYGENASE 1 demethylase activity#GO:0032451;oxidoreductase activity#GO:0016491;catalytic activity, acting on a protein#GO:0140096;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;protein demethylase activity#GO:0140457;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;histone demethylase activity#GO:0032452;dioxygenase activity#GO:0051213;histone modifying activity#GO:0140993 intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730 HUMAN|HGNC=20810|UniProtKB=O94892 O94892 ZNF432 PTHR24377:SF165 IP01015P-RELATED ZINC FINGER PROTEIN 432 transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=1951|UniProtKB=P08172 P08172 CHRM2 PTHR24247:SF207 5-HYDROXYTRYPTAMINE RECEPTOR MUSCARINIC ACETYLCHOLINE RECEPTOR M2 signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;G protein-coupled amine receptor activity#GO:0008227;neurotransmitter receptor activity#GO:0030594;molecular transducer activity#GO:0060089;postsynaptic neurotransmitter receptor activity#GO:0098960;transmembrane signaling receptor activity#GO:0004888;acetylcholine receptor activity#GO:0015464 cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;regulation of muscle system process#GO:0090257;signaling#GO:0023052;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;response to stimulus#GO:0050896;response to oxygen-containing compound#GO:1901700;trans-synaptic signaling#GO:0099537;regulation of muscle contraction#GO:0006937;G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887;response to nitrogen compound#GO:1901698;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;synaptic signaling#GO:0099536;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;cellular response to nitrogen compound#GO:1901699;acetylcholine receptor signaling pathway#GO:0095500;response to chemical#GO:0042221;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway#GO:0007193;regulation of system process#GO:0044057;regulation of smooth muscle contraction#GO:0006940 cell junction#GO:0030054;dendritic tree#GO:0097447;dendrite#GO:0030425;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;neuron projection#GO:0043005;membrane#GO:0016020 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GoPCR#P00725;Alzheimer disease-amyloid secretase pathway#P00003>Muscarinic acetylcholine receptors#P00083;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>mAChR2/4#P01077;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GqPCR#P00730 HUMAN|HGNC=15894|UniProtKB=Q9BZ23 Q9BZ23 PANK2 PTHR12280:SF25 PANTOTHENATE KINASE PANTOTHENATE KINASE 2, MITOCHONDRIAL transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773 purine-containing compound biosynthetic process#GO:0072522;organophosphate biosynthetic process#GO:0090407;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing small molecule metabolic process#GO:0055086;sulfur compound metabolic process#GO:0006790;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058 cytosol#GO:0005829;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 metabolite interconversion enzyme#PC00262;kinase#PC00137 Coenzyme A biosynthesis#P02736>Pantothenate kinase#P02885 HUMAN|HGNC=805|UniProtKB=P14415 P14415 ATP1B2 PTHR11523:SF26 SODIUM/POTASSIUM-DEPENDENT ATPASE BETA SUBUNIT SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA-2 molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;ATPase activator activity#GO:0001671 cellular homeostasis#GO:0019725;inorganic cation import across plasma membrane#GO:0098659;intracellular chemical homeostasis#GO:0055082;establishment of localization#GO:0051234;import into cell#GO:0098657;potassium ion import across plasma membrane#GO:1990573;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;chemical homeostasis#GO:0048878;monoatomic ion transmembrane transport#GO:0034220;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;monoatomic ion homeostasis#GO:0050801;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;potassium ion homeostasis#GO:0055075;monoatomic cation transport#GO:0006812;localization#GO:0051179;inorganic ion homeostasis#GO:0098771;inorganic ion import across plasma membrane#GO:0099587;homeostatic process#GO:0042592;metal ion transport#GO:0030001;export from cell#GO:0140352;import across plasma membrane#GO:0098739;sodium ion transport#GO:0006814;intracellular monoatomic ion homeostasis#GO:0006873 ATPase dependent transmembrane transport complex#GO:0098533;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;plasma membrane protein complex#GO:0098797;cation-transporting ATPase complex#GO:0090533;cell periphery#GO:0071944;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 transporter#PC00227;primary active transporter#PC00068 HUMAN|HGNC=17241|UniProtKB=O95361 O95361 TRIM16 PTHR25465:SF10 B-BOX DOMAIN CONTAINING TRIPARTITE MOTIF-CONTAINING PROTEIN 16 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=17794|UniProtKB=Q7L0Q8 Q7L0Q8 RHOU PTHR24072:SF148 RHO FAMILY GTPASE RHO-RELATED GTP-BINDING PROTEIN RHOU hydrolase activity#GO:0016787;anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167;GTPase activity#GO:0003924;ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleotide binding#GO:0000166;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;protein binding#GO:0005515;enzyme binding#GO:0019899;guanyl nucleotide binding#GO:0019001;protein kinase binding#GO:0019901;kinase binding#GO:0019900;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;nucleoside phosphate binding#GO:1901265;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;ribonucleotide binding#GO:0032553;hydrolase activity, acting on acid anhydrides#GO:0016817;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;carbohydrate derivative binding#GO:0097367 cellular component organization#GO:0016043;cellular response to stimulus#GO:0051716;establishment of cell polarity#GO:0030010;regulation of biological process#GO:0050789;endocytosis#GO:0006897;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;establishment or maintenance of cell polarity#GO:0007163;actin filament-based process#GO:0030029;localization#GO:0051179;cell communication#GO:0007154;supramolecular fiber organization#GO:0097435;organelle organization#GO:0006996;cellular process#GO:0009987;signal transduction#GO:0007165;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;transport#GO:0006810;import into cell#GO:0098657;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;actin filament organization#GO:0007015 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein#PC00020;small GTPase#PC00208 Axon guidance mediated by netrin#P00009>cdc42#P00364;Cytoskeletal regulation by Rho GTPase#P00016>Cdc42#P00515 HUMAN|HGNC=33775|UniProtKB=Q6UXT8 Q6UXT8 ALKAL1 PTHR28676:SF1 ALK AND LTK LIGAND 2-RELATED ALK AND LTK LIGAND 1 enzyme activator activity#GO:0008047;protein kinase regulator activity#GO:0019887;kinase regulator activity#GO:0019207;kinase binding#GO:0019900;binding#GO:0005488;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;enzyme regulator activity#GO:0030234;protein binding#GO:0005515;molecular function activator activity#GO:0140677;receptor tyrosine kinase binding#GO:0030971;protein kinase activator activity#GO:0030295;molecular function regulator activity#GO:0098772;signaling receptor binding#GO:0005102;protein tyrosine kinase binding#GO:1990782;kinase activator activity#GO:0019209 positive regulation of MAPK cascade#GO:0043410;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;regulation of MAPK cascade#GO:0043408;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of ERK1 and ERK2 cascade#GO:0070372;positive regulation of response to stimulus#GO:0048584;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;regulation of cell communication#GO:0010646;positive regulation of ERK1 and ERK2 cascade#GO:0070374;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967 HUMAN|HGNC=72|UniProtKB=Q9NUQ8 Q9NUQ8 ABCF3 PTHR19211:SF117 ATP-BINDING TRANSPORT PROTEIN-RELATED ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 3 nucleotide binding#GO:0000166;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167;small molecule binding#GO:0036094;ATP binding#GO:0005524;anion binding#GO:0043168;binding#GO:0005488 translation elongation factor#PC00222 HUMAN|HGNC=11808|UniProtKB=Q96EY1 Q96EY1 DNAJA3 PTHR44145:SF6 DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL protein binding#GO:0005515;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;kinase binding#GO:0019900;binding#GO:0005488 cellular component organization or biogenesis#GO:0071840;mitochondrion organization#GO:0007005;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739 chaperone#PC00072 HUMAN|HGNC=31963|UniProtKB=A5LHX3 A5LHX3 PSMB11 PTHR11599:SF48 PROTEASOME SUBUNIT ALPHA/BETA PROTEASOME SUBUNIT BETA TYPE-11 catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity#GO:0003824 proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;endopeptidase complex#GO:1905369;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;proteasome complex#GO:0000502;nucleus#GO:0005634;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;peptidase complex#GO:1905368 protease#PC00190;protein modifying enzyme#PC00260 HUMAN|HGNC=11190|UniProtKB=P56693 P56693 SOX10 PTHR45803:SF6 SOX100B TRANSCRIPTION FACTOR SOX-10 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 stem cell development#GO:0048864;system development#GO:0048731;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;tissue morphogenesis#GO:0048729;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;cell motility#GO:0048870;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;mesenchyme development#GO:0060485;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;stem cell differentiation#GO:0048863;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;epithelium development#GO:0060429;regulation of nucleobase-containing compound metabolic process#GO:0019219;neural crest cell development#GO:0014032;multicellular organismal process#GO:0032501;tissue development#GO:0009888;cell migration#GO:0016477;animal gross anatomical part developmental process#GO:0160108;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;negative regulation of biological process#GO:0048519;peripheral nervous system development#GO:0007422;negative regulation of metabolic process#GO:0009892;cell development#GO:0048468;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;neural crest cell differentiation#GO:0014033;negative regulation of RNA biosynthetic process#GO:1902679;mesenchymal cell differentiation#GO:0048762;negative regulation of RNA metabolic process#GO:0051253;morphogenesis of an epithelium#GO:0002009;multicellular organism development#GO:0007275;animal organ development#GO:0048513;neural crest cell migration#GO:0001755;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;nervous system development#GO:0007399 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 HMG box transcription factor#PC00024;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=21146|UniProtKB=Q96E35 Q96E35 ZMYND19 PTHR46831:SF1 ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 19 ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 19 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell junction#GO:0030054;membrane#GO:0016020 HUMAN|HGNC=19191|UniProtKB=Q8NF50 Q8NF50 DOCK8 PTHR23317:SF74 DEDICATOR OF CYTOKINESIS DOCK DEDICATOR OF CYTOKINESIS PROTEIN 8 molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;guanyl-nucleotide exchange factor activity#GO:0005085 positive regulation of leukocyte cell-cell adhesion#GO:1903039;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;positive regulation of cell activation#GO:0050867;regulation of cell adhesion#GO:0030155;positive regulation of cellular process#GO:0048522;positive regulation of cell migration#GO:0030335;positive regulation of locomotion#GO:0040017;regulation of cell migration#GO:0030334;regulation of response to stimulus#GO:0048583;regulation of leukocyte cell-cell adhesion#GO:1903037;regulation of cell communication#GO:0010646;regulation of leukocyte migration#GO:0002685;regulation of immune system process#GO:0002682;regulation of cell-cell adhesion#GO:0022407;regulation of cellular process#GO:0050794;positive regulation of cell adhesion#GO:0045785;regulation of cell motility#GO:2000145;positive regulation of lymphocyte activation#GO:0051251;regulation of lymphocyte migration#GO:2000401;regulation of multicellular organismal process#GO:0051239;positive regulation of T cell activation#GO:0050870;regulation of T cell activation#GO:0050863;regulation of establishment or maintenance of cell polarity#GO:0032878;positive regulation of biological process#GO:0048518;positive regulation of cell-cell adhesion#GO:0022409;positive regulation of immune system process#GO:0002684;regulation of small GTPase mediated signal transduction#GO:0051056;positive regulation of leukocyte activation#GO:0002696;regulation of lymphocyte activation#GO:0051249;regulation of Rho protein signal transduction#GO:0035023;regulation of biological process#GO:0050789;regulation of cell activation#GO:0050865;positive regulation of multicellular organismal process#GO:0051240;regulation of leukocyte activation#GO:0002694;positive regulation of cell motility#GO:2000147;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531 cellular anatomical structure#GO:0110165;cell leading edge#GO:0031252 G-protein modulator#PC00022;protein-binding activity modulator#PC00095;guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=23523|UniProtKB=Q5VZ66 Q5VZ66 JAKMIP3 PTHR18935:SF9 GOLGIN SUBFAMILY A MEMBER 4-LIKE ISOFORM X1 JANUS KINASE AND MICROTUBULE-INTERACTING PROTEIN 3 HUMAN|HGNC=3430|UniProtKB=P04626 P04626 ERBB2 PTHR24416:SF137 TYROSINE-PROTEIN KINASE RECEPTOR RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;signaling receptor activity#GO:0038023;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity, acting on a protein#GO:0140096;transmembrane signaling receptor activity#GO:0004888;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714 regulation of cell communication#GO:0010646;positive regulation of epithelial cell proliferation#GO:0050679;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;system development#GO:0048731;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;regulation of cell population proliferation#GO:0042127;cell communication#GO:0007154;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;epidermal growth factor receptor signaling pathway#GO:0007173;multicellular organismal process#GO:0032501;positive regulation of response to stimulus#GO:0048584;negative regulation of apoptotic process#GO:0043066;ERBB signaling pathway#GO:0038127;positive regulation of cellular process#GO:0048522;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;positive regulation of MAPK cascade#GO:0043410;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;signaling#GO:0023052;cell differentiation#GO:0030154;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;positive regulation of cell population proliferation#GO:0008284;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;regulation of intracellular signal transduction#GO:1902531;nervous system development#GO:0007399;cellular process#GO:0009987;signal transduction#GO:0007165;negative regulation of programmed cell death#GO:0043069;positive regulation of biological process#GO:0048518;multicellular organism development#GO:0007275;cell surface receptor signaling pathway#GO:0007166;regulation of apoptotic process#GO:0042981;regulation of MAPK cascade#GO:0043408;neuron differentiation#GO:0030182 signaling receptor complex#GO:0043235;basal plasma membrane#GO:0009925;cell periphery#GO:0071944;basal part of cell#GO:0045178;membrane#GO:0016020;plasma membrane#GO:0005886;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 transmembrane signal receptor#PC00197 Cadherin signaling pathway#P00012>EGFR#P00466;EGF receptor signaling pathway#P00018>EGFR#P00542 HUMAN|HGNC=29959|UniProtKB=Q6PID6 Q6PID6 TTC33 PTHR15544:SF0 OSMOSIS RESPONSIVE FACTOR TETRATRICOPEPTIDE REPEAT PROTEIN 33 HUMAN|HGNC=17379|UniProtKB=Q7Z5R6 Q7Z5R6 APBB1IP PTHR11243:SF14 GROWTH FACTOR RECEPTOR-BOUND PROTEIN AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1-INTERACTING PROTEIN molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 cellular component organization#GO:0016043;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;cellular response to stimulus#GO:0051716;cell projection organization#GO:0030030;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell morphogenesis#GO:0000902;signaling#GO:0023052;cell communication#GO:0007154;anatomical structure development#GO:0048856;intracellular signal transduction#GO:0035556;signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;developmental process#GO:0032502;cellular component organization or biogenesis#GO:0071840;cell projection morphogenesis#GO:0048858 cell periphery#GO:0071944;cytosol#GO:0005829;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=29656|UniProtKB=Q8WUY1 Q8WUY1 THEM6 PTHR12475:SF4 FAMILY NOT NAMED PROTEIN THEM6 HUMAN|HGNC=25597|UniProtKB=Q9NV72 Q9NV72 ZNF701 PTHR24377:SF800 IP01015P-RELATED ZINC FINGER PROTEIN 701 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=1138|UniProtKB=O00481 O00481 BTN3A1 PTHR24100:SF128 BUTYROPHILIN BUTYROPHILIN SUBFAMILY 3 MEMBER A1 protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488 cell communication#GO:0007154;regulation of immune response#GO:0050776;immune response-activating cell surface receptor signaling pathway#GO:0002429;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of macromolecule metabolic process#GO:0060255;cellular response to stimulus#GO:0051716;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;T cell receptor signaling pathway#GO:0050852;immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cytokine production#GO:0001817;immune system process#GO:0002376;signaling#GO:0023052;response to stimulus#GO:0050896;immune response-regulating signaling pathway#GO:0002764;regulation of biological process#GO:0050789;immune response-activating signaling pathway#GO:0002757;cell surface receptor signaling pathway#GO:0007166;regulation of multicellular organismal process#GO:0051239;antigen receptor-mediated signaling pathway#GO:0050851;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;signal transduction#GO:0007165;positive regulation of immune system process#GO:0002684 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell surface#GO:0009986;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=9180|UniProtKB=Q9UHN1 Q9UHN1 POLG2 PTHR10745:SF8 GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2 DNA POLYMERASE SUBUNIT GAMMA-2 enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;catalytic activity, acting on a tRNA#GO:0140101;molecular function regulator activity#GO:0098772;catalytic activity, acting on RNA#GO:0140098;enzyme activator activity#GO:0008047;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;ligase activity#GO:0016874 gene expression#GO:0010467;amino acid metabolic process#GO:0006520;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;tRNA aminoacylation#GO:0043039;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;tRNA aminoacylation for protein translation#GO:0006418;amino acid activation#GO:0043038;macromolecule metabolic process#GO:0043170;tRNA metabolic process#GO:0006399;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;protein biosynthetic process#GO:0160307;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;DNA replication#GO:0006260;RNA metabolic process#GO:0016070;protein metabolic process#GO:0019538;DNA-templated DNA replication#GO:0006261;mitochondrial DNA metabolic process#GO:0032042;translation#GO:0006412 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;organelle lumen#GO:0043233;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;DNA polymerase complex#GO:0042575;cytoplasm#GO:0005737;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;membrane-enclosed lumen#GO:0031974 aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 HUMAN|HGNC=4501|UniProtKB=O15552 O15552 FFAR2 PTHR45822:SF5 FREE FATTY ACID RECEPTOR 2-RELATED FREE FATTY ACID RECEPTOR 2 G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 response to fatty acid#GO:0070542;cell communication#GO:0007154;response to oxygen-containing compound#GO:1901700;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cellular response to fatty acid#GO:0071398;biological regulation#GO:0065007;response to lipid#GO:0033993;cellular response to lipid#GO:0071396;response to chemical#GO:0042221;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 HUMAN|HGNC=24603|UniProtKB=Q5H9I0 Q5H9I0 TFDP3 PTHR12548:SF13 TRANSCRIPTION FACTOR DP TRANSCRIPTION FACTOR DP FAMILY MEMBER 3 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=14565|UniProtKB=Q9BX66 Q9BX66 SORBS1 PTHR14167:SF64 SH3 DOMAIN-CONTAINING SORBIN AND SH3 DOMAIN-CONTAINING PROTEIN 1 signaling adaptor activity#GO:0035591;signaling receptor complex adaptor activity#GO:0030159;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 organelle organization#GO:0006996;cellular component organization#GO:0016043;cell adhesion#GO:0007155;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;cell-substrate adhesion#GO:0031589;cytoskeleton organization#GO:0007010 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cell-substrate junction#GO:0030055;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cell periphery#GO:0071944;nucleus#GO:0005634;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;membrane-bounded organelle#GO:0043227;cell junction#GO:0030054;intracellular organelle#GO:0043229 scaffold/adaptor protein#PC00226 HUMAN|HGNC=20225|UniProtKB=Q92782 Q92782 DPF1 PTHR45888:SF14 HL01030P-RELATED ZINC FINGER PROTEIN NEURO-D4 transcription regulator activity#GO:0140110;binding#GO:0005488;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription coregulator activity#GO:0003712;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;nervous system development#GO:0007399;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;developmental process#GO:0032502;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;multicellular organism development#GO:0007275;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;animal gross anatomical part developmental process#GO:0160108;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;SWI/SNF superfamily-type complex#GO:0070603;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ATPase complex#GO:1904949;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;chromatin#GO:0000785;nucleus#GO:0005634;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513 HUMAN|HGNC=12665|UniProtKB=P18206 P18206 VCL PTHR46180:SF1 VINCULIN VINCULIN protein binding#GO:0005515;beta-catenin binding#GO:0008013;binding#GO:0005488 cellular process#GO:0009987;cell adhesion#GO:0007155 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;focal adhesion#GO:0005925;cell-substrate junction#GO:0030055;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoskeleton#GO:0005856;adherens junction#GO:0005912;cell-cell contact zone#GO:0044291;cell junction#GO:0030054;membraneless organelle#GO:0043228;cell periphery#GO:0071944;membrane#GO:0016020;cell-cell junction#GO:0005911;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737 Gonadotropin-releasing hormone receptor pathway#P06664>Vinculin#P06771;Integrin signalling pathway#P00034>Vinculin#P00937 HUMAN|HGNC=28950|UniProtKB=Q15053 Q15053 KIAA0040 PTHR40382:SF1 FAMILY NOT NAMED RIKEN CDNA 4930523C07 GENE HUMAN|HGNC=30603|UniProtKB=Q3KNW5 Q3KNW5 SLC10A6 PTHR10361:SF55 SODIUM-BILE ACID COTRANSPORTER SODIUM-DEPENDENT ORGANIC ANION TRANSPORTER solute:monoatomic cation symporter activity#GO:0015294;monoatomic ion transmembrane transporter activity#GO:0015075;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;solute:sodium symporter activity#GO:0015370;monoatomic cation transmembrane transporter activity#GO:0008324;bile acid transmembrane transporter activity#GO:0015125;symporter activity#GO:0015293;carboxylic acid transmembrane transporter activity#GO:0046943 monocarboxylic acid transport#GO:0015718;organic hydroxy compound transport#GO:0015850;establishment of localization#GO:0051234;localization#GO:0051179;carboxylic acid transport#GO:0046942;organic acid transport#GO:0015849;transport#GO:0006810;bile acid and bile salt transport#GO:0015721;lipid localization#GO:0010876;lipid transport#GO:0006869;macromolecule localization#GO:0033036 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 primary active transporter#PC00068 HUMAN|HGNC=26929|UniProtKB=Q9Y2V0 Q9Y2V0 CDIN1 PTHR31661:SF2 SIMILAR TO CDNA SEQUENCE BC052040 CDAN1-INTERACTING NUCLEASE 1 anatomical structure development#GO:0048856;cellular developmental process#GO:0048869;erythrocyte differentiation#GO:0030218;multicellular organismal-level homeostasis#GO:0048871;immune system process#GO:0002376;homeostasis of number of cells#GO:0048872;developmental process#GO:0032502;multicellular organismal process#GO:0032501;myeloid cell differentiation#GO:0030099;cell differentiation#GO:0030154;cell development#GO:0048468;hemopoiesis#GO:0030097;homeostatic process#GO:0042592;cellular process#GO:0009987 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=18627|UniProtKB=P60673 P60673 PFN3 PTHR13936:SF2 PROFILIN PROFILIN-3 cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;binding#GO:0005488;protein binding#GO:0005515 regulation of protein polymerization#GO:0032271;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of cellular component biogenesis#GO:0044087;regulation of stress fiber assembly#GO:0051492;regulation of actin filament bundle assembly#GO:0032231;regulation of protein-containing complex assembly#GO:0043254;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of supramolecular fiber organization#GO:1902903;regulation of cellular component size#GO:0032535;regulation of organelle organization#GO:0033043;positive regulation of organelle organization#GO:0010638;regulation of biological quality#GO:0065008;positive regulation of cellular component organization#GO:0051130;regulation of actin filament length#GO:0030832;regulation of actin filament polymerization#GO:0030833;positive regulation of cellular component biogenesis#GO:0044089;biological regulation#GO:0065007;regulation of actin polymerization or depolymerization#GO:0008064;regulation of actin cytoskeleton organization#GO:0032956;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of actin filament organization#GO:0110053;cellular component organization or biogenesis#GO:0071840;positive regulation of actin filament bundle assembly#GO:0032233;regulation of anatomical structure size#GO:0090066;regulation of actin filament-based process#GO:0032970 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 non-motor actin binding protein#PC00165;actin or actin-binding cytoskeletal protein#PC00041 Cytoskeletal regulation by Rho GTPase#P00016>Profilin#P00521 HUMAN|HGNC=7410|UniProtKB=Q13330 Q13330 MTA1 PTHR10865:SF5 METASTASIS-ASSOCIATED PROTEIN AND MESODERM INDUCTION EARLY RESPONSE PROTEIN METASTASIS-ASSOCIATED PROTEIN MTA1 binding#GO:0005488;transcription regulator activity#GO:0140110;enzyme binding#GO:0019899;protein binding#GO:0005515;transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712;histone deacetylase binding#GO:0042826;transcription coactivator activity#GO:0003713 cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;response to stress#GO:0006950;double-strand break repair#GO:0006302;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;negative regulation of metabolic process#GO:0009892;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;response to ionizing radiation#GO:0010212;negative regulation of biological process#GO:0048519;response to abiotic stimulus#GO:0009628;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;cellular response to stress#GO:0033554;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;response to radiation#GO:0009314;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;DNA damage response#GO:0006974;DNA repair#GO:0006281;negative regulation of cellular process#GO:0048523;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355 histone deacetylase complex#GO:0000118;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;chromatin#GO:0000785;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;transcription regulator complex#GO:0005667;organelle lumen#GO:0043233;chromosome#GO:0005694;SWI/SNF superfamily-type complex#GO:0070603;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ATPase complex#GO:1904949;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=30721|UniProtKB=Q9BXG8 Q9BXG8 SPZ1 PTHR47889:SF1 SPERMATOGENIC LEUCINE ZIPPER PROTEIN 1 SPERMATOGENIC LEUCINE ZIPPER PROTEIN 1 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 basic leucine zipper transcription factor#PC00056 HUMAN|HGNC=25883|UniProtKB=Q9H7S9 Q9H7S9 ZNF703 PTHR12522:SF2 ZINC-FINGER PROTEIN NOLZ1-RELATED ZINC FINGER PROTEIN 703 regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=12286|UniProtKB=A0A075B6L2 A0A075B6L2 TRGV11 PTHR19256:SF73 T-CELL RECEPTOR GAMMA CHAIN NON-FUNCTIONAL T CELL RECEPTOR GAMMA VARIABLE 11-RELATED immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=5930|UniProtKB=A0A075B6I9 A0A075B6I9 IGLV7-46 PTHR23267:SF464 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN LAMBDA VARIABLE 7-46 immune system process#GO:0002376;immune response#GO:0006955;response to stimulus#GO:0050896 protein-containing complex#GO:0032991 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=30632|UniProtKB=O94864 O94864 SUPT7L PTHR28598:SF1 STAGA COMPLEX 65 SUBUNIT GAMMA STAGA COMPLEX 65 SUBUNIT GAMMA transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription coactivator activity#GO:0003713 HUMAN|HGNC=23567|UniProtKB=Q96EQ0 Q96EQ0 SGTB PTHR45831:SF1 LD24721P SMALL GLUTAMINE-RICH TETRATRICOPEPTIDE REPEAT-CONTAINING PROTEIN BETA establishment of protein localization to endoplasmic reticulum#GO:0072599;post-translational protein targeting to endoplasmic reticulum membrane#GO:0006620;protein targeting#GO:0006605;establishment of protein localization#GO:0045184;cellular process#GO:0009987;establishment of protein localization to membrane#GO:0090150;protein targeting to ER#GO:0045047;localization#GO:0051179;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization within membrane#GO:0051668;protein targeting to membrane#GO:0006612 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;membrane#GO:0016020;cytosol#GO:0005829 HUMAN|HGNC=31894|UniProtKB=Q5H9E4 Q5H9E4 SLC25A53 PTHR46131:SF5 SD08549P SOLUTE CARRIER FAMILY 25 MEMBER 53 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;organophosphate ester transmembrane transporter activity#GO:0015605;nucleobase-containing compound transmembrane transporter activity#GO:0015932;purine nucleotide transmembrane transporter activity#GO:0015216 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=28216|UniProtKB=Q96I36 Q96I36 COX14 PTHR36684:SF1 CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX14 CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX14 mitochondrion organization#GO:0007005;mitochondrial respiratory chain complex assembly#GO:0033108;cellular component assembly#GO:0022607;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;respiratory chain complex IV assembly#GO:0008535;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;cytochrome complex assembly#GO:0017004;mitochondrial respiratory chain complex IV assembly#GO:0033617 mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 chaperone#PC00072 HUMAN|HGNC=28902|UniProtKB=Q8IUH8 Q8IUH8 SPPL2C PTHR12174:SF38 SIGNAL PEPTIDE PEPTIDASE SIGNAL PEPTIDE PEPTIDASE-LIKE 2C catalytic activity#GO:0003824;aspartic-type endopeptidase activity#GO:0004190;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175 primary metabolic process#GO:0044238;proteolysis#GO:0006508;metabolic process#GO:0008152;cellular process#GO:0009987;membrane protein proteolysis#GO:0033619;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 lysosomal membrane#GO:0005765;cytoplasm#GO:0005737;vacuole#GO:0005773;cytoplasmic vesicle membrane#GO:0030659;cytoplasmic side of endoplasmic reticulum membrane#GO:0098554;endoplasmic reticulum#GO:0005783;cytoplasmic side of membrane#GO:0098562;bounding membrane of organelle#GO:0098588;lytic vacuole#GO:0000323;lysosome#GO:0005764;lytic vacuole membrane#GO:0098852;intracellular vesicle#GO:0097708;Golgi-associated vesicle membrane#GO:0030660;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular organelle#GO:0043229;organelle subcompartment#GO:0031984;side of membrane#GO:0098552;membrane#GO:0016020;vesicle membrane#GO:0012506;endomembrane system#GO:0012505;endoplasmic reticulum membrane#GO:0005789;Golgi-associated vesicle#GO:0005798;organelle membrane#GO:0031090;vacuolar membrane#GO:0005774;vesicle#GO:0031982;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum subcompartment#GO:0098827;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227 protein modifying enzyme#PC00260;aspartic protease#PC00053 HUMAN|HGNC=8374|UniProtKB=O60412 O60412 OR7C2 PTHR48001:SF79 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 7C2 transmembrane signal receptor#PC00197 HUMAN|HGNC=5654|UniProtKB=P01825 P01825 IGHV4-59 PTHR23266:SF323 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 4-30-2-RELATED antigen binding#GO:0003823;binding#GO:0005488 immune response#GO:0006955;response to stimulus#GO:0050896;adaptive immune response#GO:0002250;immune system process#GO:0002376;immune effector process#GO:0002252;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;immunoglobulin mediated immune response#GO:0016064;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=4103|UniProtKB=Q13070 Q13070 GAGE6 PTHR14047:SF30 P ANTIGEN FAMILY MEMBER 5-RELATED G ANTIGEN 1-RELATED HUMAN|HGNC=3321|UniProtKB=P19419 P19419 ELK1 PTHR11849:SF178 ETS ETS DOMAIN-CONTAINING PROTEIN ELK-1 DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;developmental process#GO:0032502;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;cellular process#GO:0009987;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;winged helix/forkhead transcription factor#PC00246 Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>ELK#P00890;CCKR signaling map#P06959>ELK1#P07146;Toll receptor signaling pathway#P00054>Elk1#P01341;p38 MAPK pathway#P05918>ELK#P06013;Interleukin signaling pathway#P00036>ELK#P00962;PDGF signaling pathway#P00047>ELK#P01140;Ras Pathway#P04393>Elk-1#P04573;Angiotensin II-stimulated signaling through G proteins and beta-arrestin#P05911>ELK1#P05934;Gonadotropin-releasing hormone receptor pathway#P06664>ELK1#P06785;Oxidative stress response#P00046>Elk-1#P01136;Parkinson disease#P00049>Elk-1#P01233 HUMAN|HGNC=2563|UniProtKB=O15482 O15482 TEX28 PTHR17613:SF10 CEREBRAL PROTEIN-11-RELATED TESTIS-SPECIFIC PROTEIN TEX28 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 HUMAN|HGNC=29513|UniProtKB=O60306 O60306 AQR PTHR10887:SF5 DNA2/NAM7 HELICASE FAMILY RNA HELICASE AQUARIUS RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;catalytic step 2 spliceosome#GO:0071013;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ribonucleoprotein complex#GO:1990904;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634;spliceosomal complex#GO:0005681 RNA helicase#PC00032 HUMAN|HGNC=4267|UniProtKB=Q92847 Q92847 GHSR PTHR24243:SF7 G-PROTEIN COUPLED RECEPTOR GROWTH HORMONE SECRETAGOGUE RECEPTOR TYPE 1 transmembrane signaling receptor activity#GO:0004888;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 biological regulation#GO:0065007;response to chemical#GO:0042221;signal transduction#GO:0007165;cellular process#GO:0009987;response to hormone#GO:0009725;cell communication#GO:0007154;hormone-mediated signaling pathway#GO:0009755;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;regulation of cellular process#GO:0050794;cellular response to hormone stimulus#GO:0032870;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to endogenous stimulus#GO:0009719 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021 HUMAN|HGNC=17084|UniProtKB=Q8WXH0 Q8WXH0 SYNE2 PTHR14514:SF4 PKA ANCHORING PROTEIN NESPRIN-2 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;protein-membrane adaptor activity#GO:0043495 establishment of localization#GO:0051234;regulation of plasma membrane bounded cell projection organization#GO:0120035;transport#GO:0006810;intracellular transport#GO:0046907;regulation of cilium assembly#GO:1902017;regulation of cell projection organization#GO:0031344;biological regulation#GO:0065007;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;regulation of organelle assembly#GO:1902115;regulation of cell projection assembly#GO:0060491;cellular localization#GO:0051641;localization#GO:0051179;organelle localization#GO:0051640;regulation of cellular component biogenesis#GO:0044087;centrosome localization#GO:0051642;regulation of cellular process#GO:0050794;establishment of organelle localization#GO:0051656;regulation of cellular component organization#GO:0051128;regulation of plasma membrane bounded cell projection assembly#GO:0120032;regulation of organelle organization#GO:0033043;nuclear migration#GO:0007097;regulation of biological process#GO:0050789 myofibril#GO:0030016;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;supramolecular fiber#GO:0099512;sarcoplasm#GO:0016528;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;membraneless organelle#GO:0043228;sarcomere#GO:0030017;organelle membrane#GO:0031090;nuclear membrane#GO:0031965;endoplasmic reticulum#GO:0005783;supramolecular polymer#GO:0099081;endomembrane system#GO:0012505;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;nuclear envelope#GO:0005635;intracellular membraneless organelle#GO:0043232;membrane#GO:0016020;nucleus#GO:0005634;contractile muscle fiber#GO:0043292;sarcoplasmic reticulum#GO:0016529 HUMAN|HGNC=17997|UniProtKB=Q9H9S5 Q9H9S5 FKRP PTHR13627:SF31 FUKUTIN RELATED PROTEIN RIBITOL 5-PHOSPHATE TRANSFERASE FKRP transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, for other substituted phosphate groups#GO:0016780 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;glycoprotein metabolic process#GO:0009100;protein O-linked glycosylation via mannose#GO:0035269;metabolic process#GO:0008152;biosynthetic process#GO:0009058;carbohydrate derivative metabolic process#GO:1901135;protein O-linked glycosylation#GO:0006493;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 HUMAN|HGNC=20122|UniProtKB=Q8NDG6 Q8NDG6 TDRD9 PTHR18934:SF113 ATP-DEPENDENT RNA HELICASE ATP-DEPENDENT RNA HELICASE TDRD9 isomerase activity#GO:0016853;helicase activity#GO:0004386;macromolecular conformation isomerase activity#GO:0120543;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;RNA binding#GO:0003723;ATP-dependent activity#GO:0140657;nucleic acid binding#GO:0003676;binding#GO:0005488 nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 RNA helicase#PC00032;RNA metabolism protein#PC00031 HUMAN|HGNC=16717|UniProtKB=Q7L7V1 Q7L7V1 DHX32 PTHR18934:SF88 ATP-DEPENDENT RNA HELICASE PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX32-RELATED macromolecular conformation isomerase activity#GO:0120543;catalytic activity#GO:0003824;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;isomerase activity#GO:0016853;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;spliceosomal complex#GO:0005681;nucleus#GO:0005634 RNA helicase#PC00032;RNA metabolism protein#PC00031 HUMAN|HGNC=25725|UniProtKB=Q8IWA0 Q8IWA0 WDR75 PTHR44215:SF1 WD REPEAT-CONTAINING PROTEIN 75 WD REPEAT-CONTAINING PROTEIN 75 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of transcription by RNA polymerase I#GO:0045943;positive regulation of RNA biosynthetic process#GO:1902680;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of transcription by RNA polymerase I#GO:0006356 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233 HUMAN|HGNC=2422|UniProtKB=O75390 O75390 CS PTHR11739:SF8 CITRATE SYNTHASE CITRATE SYNTHASE, MITOCHONDRIAL catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746 primary metabolic process#GO:0044238;tricarboxylic acid cycle#GO:0006099;cellular process#GO:0009987;carbohydrate metabolic process#GO:0005975;metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091;energy derivation by oxidation of organic compounds#GO:0015980;cellular respiration#GO:0045333;aerobic respiration#GO:0009060 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;mitochondrion#GO:0005739 transferase#PC00220;metabolite interconversion enzyme#PC00262 Pyruvate metabolism#P02772>Citrate Synthetase#P03141;TCA cycle#P00051>Citrate Synthase#P01267 HUMAN|HGNC=19737|UniProtKB=Q63HR2 Q63HR2 TNS2 PTHR45734:SF1 TENSIN TENSIN-2 phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;phosphoprotein phosphatase activity#GO:0004721;protein tyrosine phosphatase activity#GO:0004725;hydrolase activity#GO:0016787 negative regulation of cell communication#GO:0010648;negative regulation of cellular process#GO:0048523;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;negative regulation of response to stimulus#GO:0048585;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789 cell junction#GO:0030054;cellular anatomical structure#GO:0110165;cell-substrate junction#GO:0030055;focal adhesion#GO:0005925;anchoring junction#GO:0070161 actin or actin-binding cytoskeletal protein#PC00041;cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HUMAN|HGNC=19034|UniProtKB=Q9Y2H9 Q9Y2H9 MAST1 PTHR24356:SF150 SERINE/THREONINE-PROTEIN KINASE MICROTUBULE-ASSOCIATED SERINE_THREONINE-PROTEIN KINASE 1 transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 animal gross anatomical part developmental process#GO:0160108;intracellular signal transduction#GO:0035556;system development#GO:0048731;anatomical structure development#GO:0048856;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;regulation of cell cycle#GO:0051726;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;central nervous system development#GO:0007417;developmental process#GO:0032502;animal organ development#GO:0048513;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cellular process#GO:0009987;regulation of mitotic cell cycle#GO:0007346;signal transduction#GO:0007165;organelle organization#GO:0006996;nervous system development#GO:0007399;head development#GO:0060322;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;multicellular organismal process#GO:0032501;brain development#GO:0007420 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;somatodendritic compartment#GO:0036477;neuronal cell body#GO:0043025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell body#GO:0044297;microtubule cytoskeleton#GO:0015630 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=29982|UniProtKB=P83859 P83859 QRFP PTHR36476:SF1 OREXIGENIC NEUROPEPTIDE QRFP OREXIGENIC NEUROPEPTIDE QRFP protein binding#GO:0005515;hormone activity#GO:0005179;molecular function activator activity#GO:0140677;signaling receptor binding#GO:0005102;binding#GO:0005488;neuropeptide hormone activity#GO:0005184;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;neuropeptide receptor binding#GO:0071855;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;G protein-coupled receptor binding#GO:0001664 neuropeptide signaling pathway#GO:0007218;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;signaling#GO:0023052;regulation of multicellular organismal process#GO:0051239;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 HUMAN|HGNC=11390|UniProtKB=Q96GD4 Q96GD4 AURKB PTHR24350:SF4 SERINE/THREONINE-PROTEIN KINASE IAL-RELATED AURORA KINASE B kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 cellular component organization or biogenesis#GO:0071840;spindle organization#GO:0007051;mitotic cell cycle process#GO:1903047;microtubule-based process#GO:0007017;regulation of cell cycle process#GO:0010564;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;organelle organization#GO:0006996;cellular process#GO:0009987;microtubule cytoskeleton organization#GO:0000226;regulation of cytokinesis#GO:0032465;regulation of cell division#GO:0051302;mitotic cell cycle#GO:0000278;mitotic spindle organization#GO:0007052;regulation of cellular process#GO:0050794;regulation of cell cycle#GO:0051726;cell cycle#GO:0007049;cellular component organization#GO:0016043;microtubule cytoskeleton organization involved in mitosis#GO:1902850;regulation of biological process#GO:0050789;cell cycle process#GO:0022402 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;spindle pole#GO:0000922;midbody#GO:0030496;chromosome#GO:0005694;kinetochore#GO:0000776;microtubule#GO:0005874;spindle microtubule#GO:0005876;membrane-bounded organelle#GO:0043227;supramolecular fiber#GO:0099512;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;spindle midzone#GO:0051233;intracellular organelle#GO:0043229;supramolecular complex#GO:0099080;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;condensed chromosome, centromeric region#GO:0000779;nucleus#GO:0005634;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;microtubule organizing center#GO:0005815;spindle#GO:0005819;centrosome#GO:0005813;condensed chromosome#GO:0000793;chromosome, centromeric region#GO:0000775;cytoskeleton#GO:0005856 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=14235|UniProtKB=Q9NRN7 Q9NRN7 AASDHPPT PTHR12215:SF10 PHOSPHOPANTETHEINE TRANSFERASE L-AMINOADIPATE-SEMIALDEHYDE DEHYDROGENASE-PHOSPHOPANTETHEINYL TRANSFERASE transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, for other substituted phosphate groups#GO:0016780 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 transferase#PC00220;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=13585|UniProtKB=Q9NRD1 Q9NRD1 FBXO6 PTHR12125:SF14 F-BOX ONLY PROTEIN 6-LIKE PROTEIN F-BOX ONLY PROTEIN 6 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=4440|UniProtKB=P13224 P13224 GP1BB PTHR22650:SF7 GLYCOPROTEIN IB BETA PLATELET GLYCOPROTEIN IB BETA CHAIN Blood coagulation#P00011>GP 1bbeta#P00436 HUMAN|HGNC=32271|UniProtKB=A8MXZ1 A8MXZ1 FAM90A23 PTHR16035:SF14 PROTEIN FAM90A1 PROTEIN FAM90A10-RELATED HUMAN|HGNC=12011|UniProtKB=P07951 P07951 TPM2 PTHR19269:SF46 TROPOMYOSIN TROPOMYOSIN BETA CHAIN actin filament binding#GO:0051015;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 cytoskeleton organization#GO:0007010;multicellular organismal process#GO:0032501;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987;muscle system process#GO:0003012;cellular component organization#GO:0016043;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;system process#GO:0003008;cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;muscle contraction#GO:0006936 actin cytoskeleton#GO:0015629;organelle#GO:0043226;supramolecular complex#GO:0099080;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;actin filament#GO:0005884;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622 actin binding motor protein#PC00040 HUMAN|HGNC=11589|UniProtKB=P62380 P62380 TBPL1 PTHR10126:SF69 TATA-BOX BINDING PROTEIN TATA BOX-BINDING PROTEIN-LIKE 1 macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleic acid biosynthetic process#GO:0141187;DNA-templated transcription initiation#GO:0006352;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA biosynthetic process#GO:0032774;nucleobase-containing compound metabolic process#GO:0006139;DNA-templated transcription#GO:0006351;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 RNA metabolism protein#PC00031;general transcription factor#PC00259 Transcription regulation by bZIP transcription factor#P00055>TBP#P01399;General transcription by RNA polymerase I#P00022>TBP#P00657;General transcription by RNA polymerase I#P00022>SL1 complex#P00653;General transcription regulation#P00023>TBP#P00670 HUMAN|HGNC=2151|UniProtKB=Q14028 Q14028 CNGB1 PTHR45638:SF16 CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A CYCLIC NUCLEOTIDE-GATED CHANNEL BETA-1 transporter activity#GO:0005215;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleotide binding#GO:0032555;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;heterocyclic compound binding#GO:1901363;gated channel activity#GO:0022836;guanyl nucleotide binding#GO:0019001;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;guanyl ribonucleotide binding#GO:0032561;monoatomic cation transmembrane transporter activity#GO:0008324;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;nucleotide binding#GO:0000166;monoatomic cation channel activity#GO:0005261;ligand-gated monoatomic ion channel activity#GO:0015276;ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;channel activity#GO:0015267 cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;homeostatic process#GO:0042592;monoatomic cation transmembrane transport#GO:0098655;multicellular organismal process#GO:0032501;anatomical structure homeostasis#GO:0060249;transport#GO:0006810;monoatomic ion transport#GO:0006811;multicellular organismal-level homeostasis#GO:0048871;tissue homeostasis#GO:0001894;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;retina homeostasis#GO:0001895;localization#GO:0051179 transporter complex#GO:1990351;cation channel complex#GO:0034703;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane#GO:0005886;membrane#GO:0016020;9+0 non-motile cilium#GO:0097731;photoreceptor cell cilium#GO:0097733;cell periphery#GO:0071944;neuron projection#GO:0043005;transmembrane transporter complex#GO:1902495;non-motile cilium#GO:0097730;membrane-bounded organelle#GO:0043227;cilium#GO:0005929;cellular anatomical structure#GO:0110165;photoreceptor outer segment#GO:0001750;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;membrane protein complex#GO:0098796 ligand-gated ion channel#PC00141;ion channel#PC00133 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>cGMP-gated ion channel#P00752 HUMAN|HGNC=10388|UniProtKB=P62841 P62841 RPS15 PTHR11880:SF28 RIBOSOMAL PROTEIN S19P FAMILY MEMBER SMALL RIBOSOMAL SUBUNIT PROTEIN US19 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;ribosome#GO:0005840;cytosolic ribosome#GO:0022626;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;small ribosomal subunit#GO:0015935;ribonucleoprotein complex#GO:1990904;cytosolic small ribosomal subunit#GO:0022627 ribosomal protein#PC00202 HUMAN|HGNC=25087|UniProtKB=Q8IWE2 Q8IWE2 FAM114A1 PTHR12842:SF4 FI01459P PROTEIN NOXP20 HUMAN|HGNC=10261|UniProtKB=P08922 P08922 ROS1 PTHR24416:SF527 TYROSINE-PROTEIN KINASE RECEPTOR PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ROS transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein tyrosine kinase activity#GO:0004713;signaling receptor activity#GO:0038023;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity, acting on a protein#GO:0140096;transmembrane signaling receptor activity#GO:0004888;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein tyrosine kinase activity#GO:0004714;molecular transducer activity#GO:0060089 cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of cell communication#GO:0010646;signaling#GO:0023052;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cellular process#GO:0009987;regulation of TOR signaling#GO:0032006;signal transduction#GO:0007165;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;signaling receptor complex#GO:0043235;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=3068|UniProtKB=Q05923 Q05923 DUSP2 PTHR10159:SF109 DUAL SPECIFICITY PROTEIN PHOSPHATASE DUAL SPECIFICITY PROTEIN PHOSPHATASE 2 protein tyrosine phosphatase activity#GO:0004725;hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;protein tyrosine/serine/threonine phosphatase activity#GO:0008138;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788 anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;gastrulation#GO:0007369;negative regulation of biological process#GO:0048519;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of signaling#GO:0023051;formation of primary germ layer#GO:0001704;animal gross anatomical part developmental process#GO:0160108;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;cellular process#GO:0009987;signal transduction#GO:0007165;endoderm formation#GO:0001706;negative regulation of signal transduction#GO:0009968;embryo development#GO:0009790;regulation of MAPK cascade#GO:0043408;endoderm development#GO:0007492;anatomical structure formation involved in morphogenesis#GO:0048646;embryonic morphogenesis#GO:0048598;multicellular organism development#GO:0007275;negative regulation of MAPK cascade#GO:0043409;cellular response to stimulus#GO:0051716;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell communication#GO:0007154;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;multicellular organismal process#GO:0032501;negative regulation of response to stimulus#GO:0048585;tissue development#GO:0009888;regulation of response to stimulus#GO:0048583;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 protein phosphatase#PC00195 Oxidative stress response#P00046>MKP5#P01131 HUMAN|HGNC=21228|UniProtKB=Q96Q07 Q96Q07 BTBD9 PTHR46306:SF1 BTB/POZ DOMAIN-CONTAINING PROTEIN 9 BTB_POZ DOMAIN-CONTAINING PROTEIN 9 regulation of trans-synaptic signaling#GO:0099177;regulation of cellular process#GO:0050794;multicellular organismal process#GO:0032501;regulation of cell communication#GO:0010646;modulation of chemical synaptic transmission#GO:0050804;biological regulation#GO:0065007;regulation of biological process#GO:0050789;circadian rhythm#GO:0007623;regulation of signaling#GO:0023051;rhythmic process#GO:0048511 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=11717|UniProtKB=Q15561 Q15561 TEAD4 PTHR11834:SF2 TRANSCRIPTIONAL ENHANCER FACTOR TEF RELATED TRANSCRIPTIONAL ENHANCER FACTOR TEF-3 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 embryonic organ development#GO:0048568;animal gross anatomical part developmental process#GO:0160108;intracellular signal transduction#GO:0035556;regulation of RNA metabolic process#GO:0051252;cell communication#GO:0007154;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;signaling#GO:0023052;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;developmental process#GO:0032502;regulation of gene expression#GO:0010468;multicellular organism development#GO:0007275;regulation of biosynthetic process#GO:0009889;animal organ development#GO:0048513;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;embryo development#GO:0009790;hippo signaling#GO:0035329;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501 transcription regulator complex#GO:0005667;protein-containing complex#GO:0032991 helix-turn-helix transcription factor#PC00116;gene-specific transcriptional regulator#PC00264;winged helix/forkhead transcription factor#PC00246 HUMAN|HGNC=27270|UniProtKB=Q68BL7 Q68BL7 OLFML2A PTHR23192:SF29 OLFACTOMEDIN-RELATED OLFACTOMEDIN-LIKE PROTEIN 2A cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 structural protein#PC00211 HUMAN|HGNC=120|UniProtKB=Q99424 Q99424 ACOX2 PTHR10909:SF344 ELECTRON TRANSPORT OXIDOREDUCTASE PEROXISOMAL ACYL-COENZYME A OXIDASE 2 oxidoreductase activity#GO:0016491;heterocyclic compound binding#GO:1901363;nucleotide binding#GO:0000166;catalytic activity#GO:0003824;fatty acid binding#GO:0005504;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;lipid binding#GO:0008289;carboxylic acid binding#GO:0031406;flavin adenine dinucleotide binding#GO:0050660;anion binding#GO:0043168;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265;organic acid binding#GO:0043177 catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;small molecule catabolic process#GO:0044282;very long-chain fatty acid metabolic process#GO:0000038;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;lipid oxidation#GO:0034440;fatty acid catabolic process#GO:0009062;oxoacid metabolic process#GO:0043436;monocarboxylic acid catabolic process#GO:0072329;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;lipid catabolic process#GO:0016042;lipid modification#GO:0030258;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;fatty acid beta-oxidation#GO:0006635;fatty acid oxidation#GO:0019395 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;peroxisome#GO:0005777;microbody#GO:0042579;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HUMAN|HGNC=1593|UniProtKB=Q16589 Q16589 CCNG2 PTHR10177:SF60 CYCLINS CYCLIN-G2 cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538;protein kinase regulator activity#GO:0019887;cyclin-dependent protein kinase regulator activity#GO:0019914;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234 G1/S transition of mitotic cell cycle#GO:0000082;mitotic cell cycle phase transition#GO:0044772;mitotic cell cycle process#GO:1903047;cellular process#GO:0009987;cell cycle process#GO:0022402;cell cycle G1/S phase transition#GO:0044843;cell cycle#GO:0007049;cell cycle phase transition#GO:0044770;mitotic cell cycle#GO:0000278 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;nucleus#GO:0005634;protein kinase complex#GO:1902911;intracellular anatomical structure#GO:0005622;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex#GO:1990234 kinase activator#PC00138 HUMAN|HGNC=17189|UniProtKB=O95897 O95897 OLFM2 PTHR23192:SF27 OLFACTOMEDIN-RELATED NOELIN-2 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 structural protein#PC00211 HUMAN|HGNC=3724|UniProtKB=Q14318 Q14318 FKBP8 PTHR46512:SF3 PEPTIDYLPROLYL ISOMERASE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP8 metabolic process#GO:0008152;regulation of response to stimulus#GO:0048583;macromolecule metabolic process#GO:0043170;positive regulation of BMP signaling pathway#GO:0030513;regulation of BMP signaling pathway#GO:0030510;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;positive regulation of response to stimulus#GO:0048584;gene expression#GO:0010467;protein maturation#GO:0051604;regulation of cellular response to growth factor stimulus#GO:0090287;biological regulation#GO:0065007;biosynthetic process#GO:0009058;regulation of signal transduction#GO:0009966;regulation of signaling#GO:0023051;protein metabolic process#GO:0019538;positive regulation of signaling#GO:0023056;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092;positive regulation of signal transduction#GO:0009967;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;protein folding#GO:0006457 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrial envelope#GO:0005740;mitochondrion#GO:0005739;membrane#GO:0016020;organelle envelope#GO:0031967;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 chaperone#PC00072 HUMAN|HGNC=4016|UniProtKB=Q11128 Q11128 FUT5 PTHR11929:SF11 ALPHA- 1,3 -FUCOSYLTRANSFERASE 4-GALACTOSYL-N-ACETYLGLUCOSAMINIDE 3-ALPHA-L-FUCOSYLTRANSFERASE FUT5 fucosyltransferase activity#GO:0008417;hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740;alpha-(1->3)-fucosyltransferase activity#GO:0046920;glycosyltransferase activity#GO:0016757 glycosyltransferase#PC00111 HUMAN|HGNC=7201|UniProtKB=Q9BXT6 Q9BXT6 MOV10L1 PTHR10887:SF523 DNA2/NAM7 HELICASE FAMILY RNA HELICASE MOV10L1 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 negative regulation of metabolic process#GO:0009892;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulatory ncRNA-mediated post-transcriptional gene silencing#GO:0035194;post-transcriptional gene silencing#GO:0016441;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulatory ncRNA-mediated gene silencing#GO:0031047;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523 cytosol#GO:0005829;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;P granule#GO:0043186;intracellular anatomical structure#GO:0005622 RNA helicase#PC00032 HUMAN|HGNC=8230|UniProtKB=Q6IF42 Q6IF42 OR2A2 PTHR26453:SF82 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2A2 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;nervous system process#GO:0050877;sensory perception#GO:0007600;system process#GO:0003008;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;detection of chemical stimulus#GO:0009593;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;response to chemical#GO:0042221;response to stimulus#GO:0050896 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=28962|UniProtKB=Q15005 Q15005 SPCS2 PTHR13085:SF3 MICROSOMAL SIGNAL PEPTIDASE 25 KDA SUBUNIT SIGNAL PEPTIDASE COMPLEX SUBUNIT 2 protein targeting to ER#GO:0045047;macromolecule metabolic process#GO:0043170;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;metabolic process#GO:0008152;biosynthetic process#GO:0009058;establishment of protein localization to endoplasmic reticulum#GO:0072599;protein maturation#GO:0051604;gene expression#GO:0010467;establishment of protein localization#GO:0045184;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;localization#GO:0051179;protein metabolic process#GO:0019538;protein targeting#GO:0006605;primary metabolic process#GO:0044238 cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;peptidase complex#GO:1905368;membrane#GO:0016020;organelle membrane#GO:0031090;endoplasmic reticulum protein-containing complex#GO:0140534;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endopeptidase complex#GO:1905369 protease#PC00190 Vasopressin synthesis#P04395>Signal Peptidase#P04589 HUMAN|HGNC=4622|UniProtKB=Q8IYD1 Q8IYD1 GSPT2 PTHR23115:SF119 TRANSLATION FACTOR EUKARYOTIC PEPTIDE CHAIN RELEASE FACTOR GTP-BINDING SUBUNIT ERF3B catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;translation factor activity#GO:0180051;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924;hydrolase activity#GO:0016787 biosynthetic process#GO:0009058;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein-containing complex organization#GO:0043933;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;protein-containing complex disassembly#GO:0032984;protein biosynthetic process#GO:0160307;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;cellular component disassembly#GO:0022411;translation#GO:0006412;translational termination#GO:0006415 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 translation factor#PC00223 HUMAN|HGNC=8180|UniProtKB=Q9Y585 Q9Y585 OR1A2 PTHR48001:SF50 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 1A1-RELATED transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cell communication#GO:0007154;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=30793|UniProtKB=O60841 O60841 EIF5B PTHR43381:SF4 TRANSLATION INITIATION FACTOR IF-2-RELATED EUKARYOTIC TRANSLATION INITIATION FACTOR 5B translation initiation factor activity#GO:0003743;translation factor activity#GO:0180051 primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058;metabolic process#GO:0008152;translational initiation#GO:0006413;translation#GO:0006412;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 translation initiation factor#PC00224 HUMAN|HGNC=31710|UniProtKB=Q5JXB2 Q5JXB2 UBE2NL PTHR24068:SF138 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2 N-LIKE-RELATED ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein conjugating enzyme activity#GO:0061650;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin conjugating enzyme activity#GO:0061631;catalytic activity#GO:0003824;transferase activity#GO:0016740 protein modification process#GO:0036211;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular response to stimulus#GO:0051716;DNA replication#GO:0006260;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;response to stimulus#GO:0050896;protein modification by small protein conjugation or removal#GO:0070647;cellular response to stress#GO:0033554;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;response to stress#GO:0006950;cellular process#GO:0009987;post-translational protein modification#GO:0043687;nucleobase-containing compound metabolic process#GO:0006139;protein ubiquitination#GO:0016567;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA damage tolerance#GO:0006301;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;protein K63-linked ubiquitination#GO:0070534 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234 Ubiquitin proteasome pathway#P00060>E2#P01491;Toll receptor signaling pathway#P00054>Ubc13#P01381 HUMAN|HGNC=11010|UniProtKB=P22732 P22732 SLC2A5 PTHR23503:SF32 SOLUTE CARRIER FAMILY 2 SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 5 sugar transmembrane transporter activity#GO:0051119;carbohydrate transmembrane transporter activity#GO:0015144;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 import into cell#GO:0098657;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810;carbohydrate transport#GO:0008643;carbohydrate transmembrane transport#GO:0034219;vitamin transport#GO:0051180;import across plasma membrane#GO:0098739;cellular process#GO:0009987;D-glucose transmembrane transport#GO:1904659 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 secondary carrier transporter#PC00258 HUMAN|HGNC=5241|UniProtKB=P11142 P11142 HSPA8 PTHR19375:SF597 HEAT SHOCK PROTEIN 70KDA HEAT SHOCK COGNATE 71 KDA PROTEIN catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817;heat shock protein binding#GO:0031072;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;ATP-dependent activity#GO:0140657;protein binding#GO:0005515;hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887 cellular component organization#GO:0016043;primary metabolic process#GO:0044238;clathrin-dependent endocytosis#GO:0072583;endocytosis#GO:0006897;protein folding#GO:0006457;protein-containing complex disassembly#GO:0032984;cellular component disassembly#GO:0022411;protein metabolic process#GO:0019538;localization#GO:0051179;protein refolding#GO:0042026;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;metabolic process#GO:0008152;transport#GO:0006810;import into cell#GO:0098657;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;receptor-mediated endocytosis#GO:0006898 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 chaperone#PC00072;Hsp70 family chaperone#PC00027 Apoptosis signaling pathway#P00006>HSP70#P00321;Parkinson disease#P00049>Hsp70#P01208 HUMAN|HGNC=13417|UniProtKB=Q9Y5P8 Q9Y5P8 PPP2R3B PTHR14095:SF1 PHOSPHATASE 2A REGULATORY SUBUNIT-RELATED SERINE_THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B'' SUBUNIT BETA enzyme regulator activity#GO:0030234;phosphatase regulator activity#GO:0019208;molecular function regulator activity#GO:0098772;protein phosphatase regulator activity#GO:0019888 protein serine/threonine phosphatase complex#GO:0008287;catalytic complex#GO:1902494;protein-containing complex#GO:0032991 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HUMAN|HGNC=12146|UniProtKB=A0A0A6YYK1 A0A0A6YYK1 TRAV8-1 PTHR19367:SF31 T-CELL RECEPTOR ALPHA CHAIN V REGION T CELL RECEPTOR ALPHA VARIABLE 8-1 response to stimulus#GO:0050896;adaptive immune response#GO:0002250;immune system process#GO:0002376;immune response#GO:0006955 protein-containing complex#GO:0032991 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=33159|UniProtKB=Q3I5F7 Q3I5F7 ACOT6 PTHR10824:SF17 ACYL-COENZYME A THIOESTERASE-RELATED ACYL-COENZYME A THIOESTERASE 6 hydrolase activity#GO:0016787;fatty acyl-CoA hydrolase activity#GO:0047617;deacylase activity#GO:0160215;catalytic activity#GO:0003824;acyl-CoA hydrolase activity#GO:0016289;hydrolase activity, acting on ester bonds#GO:0016788;thiolester hydrolase activity#GO:0016790 small molecule metabolic process#GO:0044281;very long-chain fatty acid metabolic process#GO:0000038;nucleoside phosphate metabolic process#GO:0006753;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;purine-containing compound metabolic process#GO:0072521;oxoacid metabolic process#GO:0043436;nucleobase-containing compound metabolic process#GO:0006139;organophosphate metabolic process#GO:0019637;long-chain fatty acid metabolic process#GO:0001676;sulfur compound metabolic process#GO:0006790;cellular process#GO:0009987;nucleobase-containing small molecule metabolic process#GO:0055086;acyl-CoA metabolic process#GO:0006637;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;lipid metabolic process#GO:0006629 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;microbody#GO:0042579;peroxisome#GO:0005777;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 esterase#PC00097 HUMAN|HGNC=20347|UniProtKB=Q9H9C1 Q9H9C1 VIPAS39 PTHR13364:SF6 DEFECTIVE SPERMATOGENESIS PROTEIN 39 SPERMATOGENESIS-DEFECTIVE PROTEIN 39 HOMOLOG macromolecule localization#GO:0033036;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;intracellular transport#GO:0046907;vacuolar transport#GO:0007034;transport#GO:0006810;intracellular protein transport#GO:0006886;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;protein transport#GO:0015031 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=5882|UniProtKB=P01701 P01701 IGLV1-51 PTHR23267:SF470 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN LAMBDA VARIABLE 1-51 immune system process#GO:0002376;immune response#GO:0006955;response to stimulus#GO:0050896 protein-containing complex#GO:0032991 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=16256|UniProtKB=Q9H489 Q9H489 TSPY26P PTHR11875:SF177 TESTIS-SPECIFIC Y-ENCODED PROTEIN TESTIS-SPECIFIC Y-ENCODED-LIKE PROTEIN 3-RELATED protein binding#GO:0005515;binding#GO:0005488;histone binding#GO:0042393;chromatin binding#GO:0003682 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694;nucleus#GO:0005634;chromatin#GO:0000785;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=12916|UniProtKB=P52740 P52740 ZNF132 PTHR24377:SF636 IP01015P-RELATED ZINC FINGER PROTEIN 132 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=1868|UniProtKB=O15182 O15182 CETN3 PTHR23050:SF325 CALCIUM BINDING PROTEIN CENTRIN-3 cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;cation binding#GO:0043169;protein binding#GO:0005515;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;microtubule binding#GO:0008017;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 cytoskeleton organization#GO:0007010;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043 intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microtubule cytoskeleton#GO:0015630;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856 calmodulin-related#PC00061;calcium-binding protein#PC00060 HUMAN|HGNC=4114|UniProtKB=P22466 P22466 GAL PTHR16839:SF1 GALANIN GALANIN PEPTIDES signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;molecular function activator activity#GO:0140677;hormone activity#GO:0005179;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;neuropeptide hormone activity#GO:0005184 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;neuropeptide signaling pathway#GO:0007218;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 secretory vesicle#GO:0099503;endomembrane system#GO:0012505;somatodendritic compartment#GO:0036477;cytoplasm#GO:0005737;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cell body#GO:0044297;organelle#GO:0043226;cellular anatomical structure#GO:0110165;neuronal cell body#GO:0043025;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;extracellular region#GO:0005576;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410 HUMAN|HGNC=2053|UniProtKB=Q92478 Q92478 CLEC2B PTHR45710:SF15 C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN 180 C-TYPE LECTIN DOMAIN FAMILY 2 MEMBER B signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772 immune response-activating cell surface receptor signaling pathway#GO:0002429;signaling#GO:0023052;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;immune response-regulating signaling pathway#GO:0002764;regulation of biological process#GO:0050789;T cell activation#GO:0042110;leukocyte activation#GO:0045321;cell communication#GO:0007154;cell activation#GO:0001775;regulation of immune response#GO:0050776;immune system process#GO:0002376;immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;positive regulation of response to stimulus#GO:0048584;antigen receptor-mediated signaling pathway#GO:0050851;lymphocyte activation#GO:0046649;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;positive regulation of immune system process#GO:0002684;immune response-activating signaling pathway#GO:0002757;regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166;positive regulation of immune response#GO:0050778;T cell receptor signaling pathway#GO:0050852 plasma membrane#GO:0005886;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020 defense/immunity protein#PC00090 HUMAN|HGNC=549|UniProtKB=O75106 O75106 AOC2 PTHR10638:SF4 COPPER AMINE OXIDASE AMINE OXIDASE [COPPER-CONTAINING] 2 cation binding#GO:0043169;metal ion binding#GO:0046872;transition metal ion binding#GO:0046914;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;oxidoreductase activity#GO:0016491;copper ion binding#GO:0005507;catalytic activity#GO:0003824 amine metabolic process#GO:0009308;metabolic process#GO:0008152;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 oxidoreductase#PC00176;oxidase#PC00175 Phenylethylamine degradation#P02766>Phenylethylamine oxidase#P03103 HUMAN|HGNC=7803|UniProtKB=Q12986 Q12986 NFX1 PTHR12360:SF16 NUCLEAR TRANSCRIPTION FACTOR, X-BOX BINDING 1 NFX1 TRANSCRIPTIONAL REPRESSOR NF-X1 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 zinc finger transcription factor#PC00244 HUMAN|HGNC=5993|UniProtKB=P14778 P14778 IL1R1 PTHR11890:SF26 INTERLEUKIN-1 RECEPTOR FAMILY MEMBER INTERLEUKIN-1 RECEPTOR TYPE 1 transmembrane signaling receptor activity#GO:0004888;cytokine receptor activity#GO:0004896;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;immune receptor activity#GO:0140375 regulation of inflammatory response#GO:0050727;regulation of defense response#GO:0031347;regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166;regulation of response to stress#GO:0080134;cell communication#GO:0007154;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of response to external stimulus#GO:0032101 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cell surface#GO:0009986;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 p38 MAPK pathway#P05918>IL-1R#P06030 HUMAN|HGNC=9717|UniProtKB=P28328 P28328 PEX2 PTHR48178:SF3 PEROXISOME BIOGENESIS FACTOR 2 PEROXISOME BIOGENESIS FACTOR 2 catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;very long-chain fatty acid metabolic process#GO:0000038;small molecule catabolic process#GO:0044282;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;lipid oxidation#GO:0034440;fatty acid catabolic process#GO:0009062;oxoacid metabolic process#GO:0043436;peroxisome organization#GO:0007031;monocarboxylic acid catabolic process#GO:0072329;organelle organization#GO:0006996;carboxylic acid catabolic process#GO:0046395;lipid catabolic process#GO:0016042;cellular process#GO:0009987;lipid modification#GO:0030258;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;fatty acid oxidation#GO:0019395;lipid metabolic process#GO:0006629;fatty acid beta-oxidation#GO:0006635 cytoplasm#GO:0005737;peroxisomal membrane#GO:0005778;protein-containing complex#GO:0032991;microbody#GO:0042579;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;membrane#GO:0016020;intracellular protein-containing complex#GO:0140535;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234;Cdc73/Paf1 complex#GO:0016593;transcription elongation factor complex#GO:0008023;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nuclear DNA-directed RNA polymerase complex#GO:0055029;peroxisome#GO:0005777;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;RNA polymerase II, holoenzyme#GO:0016591;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695 HUMAN|HGNC=3675|UniProtKB=O95750 O95750 FGF19 PTHR11486:SF74 FIBROBLAST GROWTH FACTOR FIBROBLAST GROWTH FACTOR 19 molecular function activator activity#GO:0140677;protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;fibroblast growth factor receptor binding#GO:0005104;growth factor activity#GO:0008083;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;growth factor receptor binding#GO:0070851 multicellular organism development#GO:0007275;regulation of MAPK cascade#GO:0043408;cell surface receptor signaling pathway#GO:0007166;nervous system development#GO:0007399;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;cellular response to fibroblast growth factor stimulus#GO:0044344;positive regulation of signaling#GO:0023056;cellular response to growth factor stimulus#GO:0071363;animal gross anatomical part developmental process#GO:0160108;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;cell differentiation#GO:0030154;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;signaling#GO:0023052;positive regulation of cell population proliferation#GO:0008284;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;cellular developmental process#GO:0048869;positive regulation of MAPK cascade#GO:0043410;neurogenesis#GO:0022008;response to fibroblast growth factor#GO:0071774;regulation of cell migration#GO:0030334;positive regulation of intracellular signal transduction#GO:1902533;developmental process#GO:0032502;regulation of response to stimulus#GO:0048583;positive regulation of response to stimulus#GO:0048584;multicellular organismal process#GO:0032501;fibroblast growth factor receptor signaling pathway#GO:0008543;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of locomotion#GO:0040012;positive regulation of cellular process#GO:0048522;regulation of cell population proliferation#GO:0042127;cell communication#GO:0007154;regulation of cell motility#GO:2000145;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;system development#GO:0048731;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;response to growth factor#GO:0070848;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of cell communication#GO:0010646;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 growth factor#PC00112;intercellular signal molecule#PC00207 HUMAN|HGNC=30857|UniProtKB=Q96DI7 Q96DI7 SNRNP40 PTHR44006:SF1 U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;catalytic step 2 spliceosome#GO:0071013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ribonucleoprotein complex#GO:1990904;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;spliceosomal complex#GO:0005681 mRNA splicing#P00058>U5#P01474 HUMAN|HGNC=21231|UniProtKB=Q5SW24 Q5SW24 DACT2 PTHR15919:SF13 DAPPER-RELATED DAPPER HOMOLOG 2 regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111;negative regulation of biological process#GO:0048519;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092;regulation of biological process#GO:0050789;negative regulation of cell communication#GO:0010648;negative regulation of canonical Wnt signaling pathway#GO:0090090;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;negative regulation of response to stimulus#GO:0048585;negative regulation of Wnt signaling pathway#GO:0030178;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;regulation of canonical Wnt signaling pathway#GO:0060828;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=3173|UniProtKB=O43854 O43854 EDIL3 PTHR24543:SF333 MULTICOPPER OXIDASE-RELATED EGF-LIKE REPEAT AND DISCOIDIN I-LIKE DOMAIN-CONTAINING PROTEIN 3 regulation of cellular process#GO:0050794;regulation of cell adhesion#GO:0030155;biological regulation#GO:0065007;regulation of cell-substrate adhesion#GO:0010810;positive regulation of cell adhesion#GO:0045785;positive regulation of cell-substrate adhesion#GO:0010811;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 oxidoreductase#PC00176 HUMAN|HGNC=27254|UniProtKB=Q3MIR4 Q3MIR4 TMEM30B PTHR10926:SF19 CELL CYCLE CONTROL PROTEIN 50 CELL CYCLE CONTROL PROTEIN 50B protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;enzyme-substrate adaptor activity#GO:0140767 regulation of membrane lipid distribution#GO:0097035;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;transport#GO:0006810;phospholipid translocation#GO:0045332;phospholipid transport#GO:0015914;biological regulation#GO:0065007;membrane organization#GO:0061024;lipid transport#GO:0006869;cellular process#GO:0009987;macromolecule localization#GO:0033036;regulation of biological quality#GO:0065008;localization#GO:0051179;lipid localization#GO:0010876;lipid translocation#GO:0034204;organophosphate ester transport#GO:0015748;cellular component organization#GO:0016043 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;cell periphery#GO:0071944 HUMAN|HGNC=12517|UniProtKB=P25874 P25874 UCP1 PTHR45618:SF19 MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED MITOCHONDRIAL BROWN FAT UNCOUPLING PROTEIN 1 monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;proton transmembrane transporter activity#GO:0015078 regulation of multicellular organismal process#GO:0051239;response to temperature stimulus#GO:0009266;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;establishment of localization in cell#GO:0051649;response to stress#GO:0006950;multicellular organismal-level homeostasis#GO:0048871;establishment of localization#GO:0051234;transport#GO:0006810;intracellular transport#GO:0046907;temperature homeostasis#GO:0001659;homeostatic process#GO:0042592;response to cold#GO:0009409;mitochondrial transport#GO:0006839;response to stimulus#GO:0050896;positive regulation of multicellular organismal process#GO:0051240;regulation of biological process#GO:0050789;response to abiotic stimulus#GO:0009628;cellular localization#GO:0051641;transmembrane transport#GO:0055085;localization#GO:0051179;mitochondrial transmembrane transport#GO:1990542;adaptive thermogenesis#GO:1990845 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;organelle envelope#GO:0031967;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 transporter#PC00227;secondary carrier transporter#PC00258 HUMAN|HGNC=8507|UniProtKB=Q99650 Q99650 OSMR PTHR23036:SF95 CYTOKINE RECEPTOR ONCOSTATIN-M-SPECIFIC RECEPTOR SUBUNIT BETA cytokine receptor activity#GO:0004896;immune receptor activity#GO:0140375;signaling receptor activity#GO:0038023;cytokine binding#GO:0019955;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;protein binding#GO:0005515 cell surface receptor signaling pathway#GO:0007166;response to cytokine#GO:0034097;response to chemical#GO:0042221;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of cell population proliferation#GO:0042127;cell communication#GO:0007154;response to peptide#GO:1901652;cytokine-mediated signaling pathway#GO:0019221;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;positive regulation of cell population proliferation#GO:0008284;cellular response to stimulus#GO:0051716;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789 signaling receptor complex#GO:0043235;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=5321|UniProtKB=Q12891 Q12891 HYAL2 PTHR11769:SF6 HYALURONIDASE HYALURONIDASE-2 hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 aminoglycan catabolic process#GO:0006026;macromolecule metabolic process#GO:0043170;macromolecule catabolic process#GO:0009057;aminoglycan metabolic process#GO:0006022;metabolic process#GO:0008152;glycosaminoglycan catabolic process#GO:0006027;catabolic process#GO:0009056;carbohydrate derivative catabolic process#GO:1901136;glycosaminoglycan metabolic process#GO:0030203;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135 intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular vesicle#GO:0097708;vesicle#GO:0031982 glycosidase#PC00110 HUMAN|HGNC=9665|UniProtKB=P23467 P23467 PTPRB PTHR46957:SF2 CYTOKINE RECEPTOR RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE BETA protein binding#GO:0005515;binding#GO:0005488;cell adhesion molecule binding#GO:0050839 multicellular organism development#GO:0007275;angiogenesis#GO:0001525;anatomical structure development#GO:0048856;system development#GO:0048731;anatomical structure formation involved in morphogenesis#GO:0048646;vasculature development#GO:0001944;animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502;circulatory system development#GO:0072359;multicellular organismal process#GO:0032501;tube development#GO:0035295;blood vessel morphogenesis#GO:0048514;anatomical structure morphogenesis#GO:0009653;tube morphogenesis#GO:0035239;blood vessel development#GO:0001568 protein-containing complex#GO:0032991;signaling receptor complex#GO:0043235 transmembrane signal receptor#PC00197 Angiogenesis#P00005>VE-PTP#P00250 HUMAN|HGNC=7228|UniProtKB=P22897 P22897 MRC1 PTHR22803:SF104 MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED MACROPHAGE MANNOSE RECEPTOR 1 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 receptor-mediated endocytosis#GO:0006898;import into cell#GO:0098657;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810;vesicle-mediated transport#GO:0016192;endocytosis#GO:0006897;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 membrane trafficking regulatory protein#PC00151 HUMAN|Ensembl=ENSG00000284555.3|UniProtKB=A0A2R8YCY7 A0A2R8YCY7 PTHR11738:SF168 MHC CLASS I NK CELL RECEPTOR IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN-RELATED transmembrane signaling receptor activity#GO:0004888;immune receptor activity#GO:0140375;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;immune response-regulating signaling pathway#GO:0002764;cellular response to stimulus#GO:0051716;immune response-regulating cell surface receptor signaling pathway#GO:0002768;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of immune response#GO:0050776;regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=17071|UniProtKB=Q9H3R0 Q9H3R0 KDM4C PTHR10694:SF104 LYSINE-SPECIFIC DEMETHYLASE LYSINE-SPECIFIC DEMETHYLASE 4C dioxygenase activity#GO:0051213;histone modifying activity#GO:0140993;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;histone demethylase activity#GO:0032452;catalytic activity, acting on a protein#GO:0140096;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;demethylase activity#GO:0032451;oxidoreductase activity#GO:0016491;protein demethylase activity#GO:0140457 regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;chromatin organization#GO:0006325;chromatin remodeling#GO:0006338;regulation of metabolic process#GO:0019222;cellular component organization#GO:0016043;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 histone modifying enzyme#PC00261 HUMAN|HGNC=26551|UniProtKB=Q8IYY4 Q8IYY4 DZIP1L PTHR21502:SF8 ZINC FINGER PROTEIN DZIP1 CILIUM ASSEMBLY PROTEIN DZIP1L plasma membrane bounded cell projection assembly#GO:0120031;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component assembly#GO:0022607;cell projection organization#GO:0030030;plasma membrane bounded cell projection organization#GO:0120036 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;cilium#GO:0005929;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;ciliary basal body#GO:0036064;microtubule organizing center#GO:0005815;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;microtubule cytoskeleton#GO:0015630 microtubule or microtubule-binding cytoskeletal protein#PC00157;cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HUMAN|HGNC=644|UniProtKB=P10275 P10275 AR PTHR48092:SF13 KNIRPS-RELATED PROTEIN-RELATED ANDROGEN RECEPTOR sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023;transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;molecular transducer activity#GO:0060089;DNA binding#GO:0003677;nuclear receptor activity#GO:0004879;transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676 regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;multicellular organismal process#GO:0032501;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;cellular response to stimulus#GO:0051716;steroid hormone receptor signaling pathway#GO:0043401;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;intracellular receptor signaling pathway#GO:0030522;response to steroid hormone#GO:0048545;sexual reproduction#GO:0019953;anatomical structure development#GO:0048856;multicellular organismal reproductive process#GO:0048609;regulation of RNA metabolic process#GO:0051252;cellular process#GO:0009987;signal transduction#GO:0007165;male gonad development#GO:0008584;positive regulation of biological process#GO:0048518;cellular response to lipid#GO:0071396;positive regulation of macromolecule metabolic process#GO:0010604;cellular response to steroid hormone stimulus#GO:0071383;multicellular organism development#GO:0007275;regulation of biological process#GO:0050789;cellular response to hormone stimulus#GO:0032870;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;animal gross anatomical part developmental process#GO:0160108;cellular response to chemical stimulus#GO:0070887;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of macromolecule biosynthetic process#GO:0010556;nuclear receptor-mediated steroid hormone signaling pathway#GO:0030518;male gamete generation#GO:0048232;nuclear receptor-mediated signaling pathway#GO:0141193;gonad development#GO:0008406;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;development of primary male sexual characteristics#GO:0046546;male sex differentiation#GO:0046661;spermatogenesis#GO:0007283;developmental process#GO:0032502;regulation of gene expression#GO:0010468;developmental process involved in reproduction#GO:0003006;reproductive process#GO:0022414;regulation of DNA-templated transcription#GO:0006355;cell communication#GO:0007154;positive regulation of biosynthetic process#GO:0009891;intracellular signal transduction#GO:0035556;reproductive system development#GO:0061458;system development#GO:0048731;response to hormone#GO:0009725;sex differentiation#GO:0007548;response to lipid#GO:0033993;response to chemical#GO:0042221;positive regulation of transcription by RNA polymerase II#GO:0045944;development of primary sexual characteristics#GO:0045137;animal organ development#GO:0048513;response to endogenous stimulus#GO:0009719;gamete generation#GO:0007276;cellular response to endogenous stimulus#GO:0071495;reproductive structure development#GO:0048608;signaling#GO:0023052;hormone-mediated signaling pathway#GO:0009755;positive regulation of metabolic process#GO:0009893 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694;chromatin#GO:0000785;nucleus#GO:0005634;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 zinc finger transcription factor#PC00244;C4 zinc finger nuclear receptor#PC00169 Gonadotropin-releasing hormone receptor pathway#P06664>AR#P06774 HUMAN|HGNC=1106|UniProtKB=Q9NXR7 Q9NXR7 BABAM2 PTHR15189:SF8 BRISC AND BRCA1-A COMPLEX MEMBER 2 BRISC AND BRCA1-A COMPLEX MEMBER 2 cellular response to stress#GO:0033554;DNA damage response#GO:0006974;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;nucleobase-containing compound metabolic process#GO:0006139;response to stimulus#GO:0050896 nuclear protein-containing complex#GO:0140513;ubiquitin ligase complex#GO:0000151;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle#GO:0043229;organelle#GO:0043226;nuclear ubiquitin ligase complex#GO:0000152;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 HUMAN|HGNC=13387|UniProtKB=Q86SG6 Q86SG6 NEK8 PTHR44535:SF4 PROTEIN CBG16200 SERINE_THREONINE-PROTEIN KINASE NEK8 catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 multicellular organism development#GO:0007275;animal organ development#GO:0048513;specification of symmetry#GO:0009799;left/right pattern formation#GO:0060972;developmental process#GO:0032502;regulation of response to stimulus#GO:0048583;heart development#GO:0007507;regionalization#GO:0003002;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;determination of bilateral symmetry#GO:0009855;anatomical structure development#GO:0048856;system development#GO:0048731;regulation of intracellular signal transduction#GO:1902531;animal gross anatomical part developmental process#GO:0160108;pattern specification process#GO:0007389;regulation of signaling#GO:0023051;circulatory system development#GO:0072359;regulation of cellular process#GO:0050794;regulation of hippo signaling#GO:0035330;regulation of cell communication#GO:0010646;determination of left/right symmetry#GO:0007368;regulation of biological process#GO:0050789 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cilium#GO:0005929 HUMAN|HGNC=4809|UniProtKB=Q9UJM8 Q9UJM8 HAO1 PTHR10578:SF151 S -2-HYDROXY-ACID OXIDASE-RELATED 2-HYDROXYACID OXIDASE 1 oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;catalytic activity#GO:0003824 biosynthetic process#GO:0009058;hydrogen peroxide metabolic process#GO:0042743;metabolic process#GO:0008152;reactive oxygen species metabolic process#GO:0072593;cellular process#GO:0009987 oxidoreductase#PC00176 HUMAN|HGNC=10380|UniProtKB=O15235 O15235 MRPS12 PTHR11652:SF1 30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER SMALL RIBOSOMAL SUBUNIT PROTEIN US12M structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;translation#GO:0006412;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 ribosome#GO:0005840;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228;cellular anatomical structure#GO:0110165;organelle#GO:0043226 ribosomal protein#PC00202 HUMAN|HGNC=26158|UniProtKB=Q96FG2 Q96FG2 ELMOD3 PTHR12771:SF2 ENGULFMENT AND CELL MOTILITY ELMO DOMAIN-CONTAINING PROTEIN 3 plasma membrane bounded cell projection organization#GO:0120036;cell projection organization#GO:0030030;cellular component assembly#GO:0022607;cellular process#GO:0009987;cell projection assembly#GO:0030031;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cilium organization#GO:0044782;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection assembly#GO:0120031;organelle assembly#GO:0070925 Golgi apparatus#GO:0005794;cilium#GO:0005929;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995 scaffold/adaptor protein#PC00226 HUMAN|HGNC=25673|UniProtKB=P0C7W0 P0C7W0 PRR29 PTHR28604:SF1 FAMILY NOT NAMED PROLINE-RICH PROTEIN 29 HUMAN|HGNC=21688|UniProtKB=O43257 O43257 ZNHIT1 PTHR13093:SF0 ZINC FINGER HIT DOMAIN CONTAINING PROTEIN 1 ZINC FINGER HIT DOMAIN-CONTAINING PROTEIN 1 binding#GO:0005488;chromatin binding#GO:0003682;protein-containing complex binding#GO:0044877;nucleosome binding#GO:0031491 nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;chromatin#GO:0000785;nucleus#GO:0005634;histone deacetylase complex#GO:0000118;membrane-enclosed lumen#GO:0031974;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;SWI/SNF superfamily-type complex#GO:0070603;chromosome#GO:0005694;organelle lumen#GO:0043233;INO80-type complex#GO:0097346;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Swr1 complex#GO:0000812;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ATPase complex#GO:1904949;intracellular organelle lumen#GO:0070013 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=8903|UniProtKB=O95336 O95336 PGLS PTHR11054:SF0 6-PHOSPHOGLUCONOLACTONASE 6-PHOSPHOGLUCONOLACTONASE catalytic activity#GO:0003824;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;6-phosphogluconolactonase activity#GO:0017057 nucleotide metabolic process#GO:0009117;pentose-phosphate shunt#GO:0006098;NADPH regeneration#GO:0006740;pyridine-containing compound metabolic process#GO:0072524;glucose 6-phosphate metabolic process#GO:0051156;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091;pentose-phosphate shunt, oxidative branch#GO:0009051;nucleobase-containing compound metabolic process#GO:0006139;NADP+ metabolic process#GO:0006739;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;nicotinamide nucleotide metabolic process#GO:0046496 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 hydrolase#PC00121;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=41912|UniProtKB=P0DH78 P0DH78 RNF224 PTHR47454:SF1 RING FINGER PROTEIN 224 RING FINGER PROTEIN 224 HUMAN|HGNC=30457|UniProtKB=A6NED2 A6NED2 RCCD1 PTHR46849:SF1 RCC1 DOMAIN-CONTAINING PROTEIN 1 RCC1 DOMAIN-CONTAINING PROTEIN 1 HUMAN|HGNC=11642|UniProtKB=P37275 P37275 ZEB1 PTHR24391:SF17 HISTONE H4 TRANSCRIPTION FACTOR-RELATED ZINC FINGER E-BOX-BINDING HOMEOBOX 1 cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;nervous system development#GO:0007399;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;developmental process#GO:0032502;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;multicellular organism development#GO:0007275;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;central nervous system development#GO:0007417;regulation of transcription by RNA polymerase II#GO:0006357;animal gross anatomical part developmental process#GO:0160108;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 Gonadotropin-releasing hormone receptor pathway#P06664>Zeb1#G06670;Gonadotropin-releasing hormone receptor pathway#P06664>Zeb1#G06884;Gonadotropin-releasing hormone receptor pathway#P06664>Zeb1#P06783 HUMAN|HGNC=15991|UniProtKB=Q96KR4 Q96KR4 LMLN PTHR10942:SF0 LEISHMANOLYSIN-LIKE PEPTIDASE LEISHMANOLYSIN-LIKE PEPTIDASE catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protease#PC00190;metalloprotease#PC00153;protein modifying enzyme#PC00260 HUMAN|HGNC=10927|UniProtKB=O15403 O15403 SLC16A6 PTHR11360:SF20 MONOCARBOXYLATE TRANSPORTER MONOCARBOXYLATE TRANSPORTER 7 monocarboxylic acid transmembrane transporter activity#GO:0008028;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;carboxylic acid transmembrane transporter activity#GO:0046943 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227 HUMAN|HGNC=13568|UniProtKB=Q9NXJ5 Q9NXJ5 PGPEP1 PTHR23402:SF16 PROTEASE FAMILY C15 PYROGLUTAMYL-PEPTIDASE I-RELATED PYROGLUTAMYL-PEPTIDASE 1 catalytic activity#GO:0003824;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 cellular process#GO:0009987;primary metabolic process#GO:0044238;catabolic process#GO:0009056;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cysteine protease#PC00081 HUMAN|HGNC=51715|UniProtKB=A0A096LPI5 A0A096LPI5 CCDC28A-AS1 PTHR12138:SF149 PRIMATE-EXPANDED PROTEIN FAMILY SUBFAMILY NOT NAMED HUMAN|HGNC=13445|UniProtKB=Q6PXP3 Q6PXP3 SLC2A7 PTHR23503:SF30 SOLUTE CARRIER FAMILY 2 SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 7 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;sugar transmembrane transporter activity#GO:0051119;carbohydrate transmembrane transporter activity#GO:0015144 carbohydrate transport#GO:0008643;transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;import into cell#GO:0098657;D-glucose transmembrane transport#GO:1904659;cellular process#GO:0009987;import across plasma membrane#GO:0098739;vitamin transport#GO:0051180;carbohydrate transmembrane transport#GO:0034219 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258 HUMAN|HGNC=7047|UniProtKB=Q9UM21 Q9UM21 MGAT4A PTHR12062:SF4 N-ACETYLGLUCOSAMINYLTRANSFERASE VI ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 4-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE A catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;acetylglucosaminyltransferase activity#GO:0008375 biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487;glycoprotein biosynthetic process#GO:0009101;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100 endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;Golgi apparatus subcompartment#GO:0098791;Golgi stack#GO:0005795;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622 transferase#PC00220 HUMAN|HGNC=29679|UniProtKB=Q9Y3D7 Q9Y3D7 PAM16 PTHR12388:SF0 MITOCHONDRIA ASSOCIATED GRANULOCYTE MACROPHAGE CSF SIGNALING MOLECULE MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM16 protein import into mitochondrial matrix#GO:0030150;mitochondrial protein import pathway#GO:7770058;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;macromolecule localization#GO:0033036;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;intracellular protein transmembrane transport#GO:0065002;establishment of protein localization to organelle#GO:0072594;intracellular protein transport#GO:0006886;protein transmembrane transport#GO:0071806;transport#GO:0006810;protein transmembrane import into intracellular organelle#GO:0044743;intracellular transport#GO:0046907;protein localization to organelle#GO:0033365;mitochondrial transport#GO:0006839;protein localization to mitochondrion#GO:0070585;protein transport#GO:0015031;cellular localization#GO:0051641;transmembrane transport#GO:0055085;localization#GO:0051179;mitochondrial transmembrane transport#GO:1990542 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;organelle lumen#GO:0043233;organelle envelope#GO:0031967;membrane protein complex#GO:0098796;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;TIM23 mitochondrial import inner membrane translocase complex#GO:0005744;mitochondrial membrane#GO:0031966;membrane-enclosed lumen#GO:0031974;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;organelle membrane#GO:0031090;inner mitochondrial membrane protein complex#GO:0098800 transporter#PC00227 HUMAN|HGNC=4183|UniProtKB=P32456 P32456 GBP2 PTHR10751:SF112 GUANYLATE BINDING PROTEIN GUANYLATE-BINDING PROTEIN 2 catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;enzyme inhibitor activity#GO:0004857;hydrolase activity, acting on acid anhydrides#GO:0016817;endopeptidase inhibitor activity#GO:0004866;ribonucleoside triphosphate phosphatase activity#GO:0017111;molecular function regulator activity#GO:0098772;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;GTPase activity#GO:0003924;peptidase regulator activity#GO:0061134;enzyme regulator activity#GO:0030234;hydrolase activity#GO:0016787;molecular function inhibitor activity#GO:0140678 response to other organism#GO:0051707;defense response to other organism#GO:0098542;defense response to symbiont#GO:0140546;immune response#GO:0006955;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;response to external stimulus#GO:0009605;defense response#GO:0006952;innate immune response#GO:0045087;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;antiviral innate immune response#GO:0140374;defense response to virus#GO:0051607;response to virus#GO:0009615;immune system process#GO:0002376 intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 heterotrimeric G-protein#PC00117;G-protein#PC00020 HUMAN|HGNC=19369|UniProtKB=Q8NEY8 Q8NEY8 PPHLN1 PTHR15836:SF4 PERIPHILIN 1 PERIPHILIN-1 localization#GO:0051179;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;protein localization to organelle#GO:0033365;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;negative regulation of gene expression, epigenetic#GO:0045814;regulation of biosynthetic process#GO:0009889;intracellular protein localization#GO:0008104;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;chromatin organization#GO:0006325;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;negative regulation of macromolecule biosynthetic process#GO:0010558;macromolecule localization#GO:0033036;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;epigenetic regulation of gene expression#GO:0040029;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987 organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 HUMAN|HGNC=30388|UniProtKB=A5D8T8 A5D8T8 CLEC18A PTHR10334:SF521 CYSTEINE-RICH SECRETORY PROTEIN-RELATED C-TYPE LECTIN DOMAIN FAMILY 18 MEMBER A-RELATED carbohydrate binding#GO:0030246;binding#GO:0005488;polysaccharide binding#GO:0030247 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090 HUMAN|HGNC=11979|UniProtKB=P50616 P50616 TOB1 PTHR17537:SF6 TRANSDUCER OF ERBB2 TOB PROTEIN TOB1 transcription regulator activity#GO:0140110;transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=13814|UniProtKB=Q9H427 Q9H427 KCNK15 PTHR11003:SF18 POTASSIUM CHANNEL, SUBFAMILY K POTASSIUM CHANNEL SUBFAMILY K MEMBER 15 potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;potassium channel activity#GO:0005267;outward rectifier potassium channel activity#GO:0015271;monoatomic cation channel activity#GO:0005261;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated monoatomic ion channel activity#GO:0005244;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;transporter activity#GO:0005215 transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;transport#GO:0006810;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;potassium ion transmembrane transport#GO:0071805;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=20044|UniProtKB=Q8WXD5 Q8WXD5 GEMIN6 PTHR14710:SF2 GEM-ASSOCIATED PROTEIN 6 GEM-ASSOCIATED PROTEIN 6 RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;ribonucleoprotein complex biogenesis#GO:0022613;spliceosomal snRNP assembly#GO:0000387;mRNA splicing, via spliceosome#GO:0000398;protein-containing complex assembly#GO:0065003;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;RNA metabolic process#GO:0016070;protein-RNA complex assembly#GO:0022618;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;cellular component assembly#GO:0022607;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;mRNA processing#GO:0006397;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-RNA complex organization#GO:0071826;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654 SMN complex#GO:0032797;intracellular anatomical structure#GO:0005622;SMN-Sm protein complex#GO:0034719;cytoplasm#GO:0005737;Sm-like protein family complex#GO:0120114;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 HUMAN|HGNC=30930|UniProtKB=Q8WWM1 Q8WWM1 XAGE5 PTHR14047:SF38 P ANTIGEN FAMILY MEMBER 5-RELATED X ANTIGEN FAMILY MEMBER 5 HUMAN|HGNC=28569|UniProtKB=Q8N635 Q8N635 MEIOB PTHR21166:SF2 CELL DIVISION CONTROL PROTEIN 24 OB DOMAIN-CONTAINING PROTEIN-RELATED MEIOSIS-SPECIFIC WITH OB DOMAIN-CONTAINING PROTEIN exonuclease activity#GO:0004527;nuclease activity#GO:0004518;DNA exonuclease activity, producing 5'-phosphomonoesters#GO:0016895;3'-5'-DNA exonuclease activity#GO:0008296;hydrolase activity#GO:0016787;DNA exonuclease activity#GO:0004529;hydrolase activity, acting on ester bonds#GO:0016788;DNA nuclease activity#GO:0004536;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;3'-5' exonuclease activity#GO:0008408;catalytic activity, acting on DNA#GO:0140097 nuclear division#GO:0000280;cellular response to stress#GO:0033554;reciprocal meiotic recombination#GO:0007131;response to stimulus#GO:0050896;cellular component organization#GO:0016043;meiosis I#GO:0007127;meiotic cell cycle process#GO:1903046;cell cycle process#GO:0022402;double-strand break repair via homologous recombination#GO:0000724;cellular component organization or biogenesis#GO:0071840;double-strand break repair#GO:0006302;metabolic process#GO:0008152;meiotic cell cycle#GO:0051321;DNA metabolic process#GO:0006259;DNA recombination#GO:0006310;organelle organization#GO:0006996;response to stress#GO:0006950;cellular process#GO:0009987;organelle fission#GO:0048285;meiosis I cell cycle process#GO:0061982;recombinational repair#GO:0000725;sexual reproduction#GO:0019953;reproductive process#GO:0022414;homologous recombination#GO:0035825;cell cycle#GO:0007049;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;reciprocal homologous recombination#GO:0140527;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;meiotic nuclear division#GO:0140013;DNA repair#GO:0006281;DNA damage response#GO:0006974;nucleobase-containing compound metabolic process#GO:0006139;resolution of meiotic recombination intermediates#GO:0000712 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=14702|UniProtKB=Q8NGB2 Q8NGB2 OR4C5 PTHR48002:SF13 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 4C5 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=51242|UniProtKB=P0DMR2 P0DMR2 SCGB1C2 PTHR10136:SF8 SECRETOGLOBIN FAMILY 1 MEMBER SECRETOGLOBIN FAMILY 1C MEMBER 1-RELATED cytokine#PC00083 HUMAN|HGNC=1508|UniProtKB=P55210 P55210 CASP7 PTHR10454:SF31 CASPASE CASPASE-7 peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;cysteine-type endopeptidase activity#GO:0004197;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234 regulation of programmed cell death#GO:0043067;programmed cell death#GO:0012501;execution phase of apoptosis#GO:0097194;regulation of biological process#GO:0050789;apoptotic process#GO:0006915;cell death#GO:0008219;positive regulation of programmed cell death#GO:0043068;regulation of cellular process#GO:0050794;positive regulation of neuron apoptotic process#GO:0043525;regulation of apoptotic process#GO:0042981;positive regulation of apoptotic process#GO:0043065;regulation of neuron apoptotic process#GO:0043523;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 protease#PC00190;protein modifying enzyme#PC00260 Apoptosis signaling pathway#P00006>Caspase 7#P00300;FAS signaling pathway#P00020>Pro-Caspase7#P00605;FAS signaling pathway#P00020>Caspase7#P00595 HUMAN|HGNC=25396|UniProtKB=Q5SZK8 Q5SZK8 FREM2 PTHR45739:SF4 MATRIX PROTEIN, PUTATIVE-RELATED FRAS1-RELATED EXTRACELLULAR MATRIX PROTEIN 2 cellular process#GO:0009987;multicellular organismal process#GO:0032501;anatomical structure homeostasis#GO:0060249;epithelial structure maintenance#GO:0010669;homeostatic process#GO:0042592;cell-matrix adhesion#GO:0007160;cell adhesion#GO:0007155;cell-substrate adhesion#GO:0031589;tissue homeostasis#GO:0001894;multicellular organismal-level homeostasis#GO:0048871 extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cellular anatomical structure#GO:0110165 HUMAN|HGNC=3319|UniProtKB=Q99607 Q99607 ELF4 PTHR11849:SF170 ETS ETS-RELATED TRANSCRIPTION FACTOR ELF-4 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700 regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 winged helix/forkhead transcription factor#PC00246;DNA-binding transcription factor#PC00218 PDGF signaling pathway#P00047>Ets#P01167 HUMAN|HGNC=25243|UniProtKB=Q6ZRH7 Q6ZRH7 CATSPERG PTHR14327:SF1 CATION CHANNEL SPERM-ASSOCIATED PROTEIN SUBUNIT GAMMA CATION CHANNEL SPERM-ASSOCIATED AUXILIARY SUBUNIT GAMMA transmembrane transporter complex#GO:1902495;membrane-bounded organelle#GO:0043227;cilium#GO:0005929;organelle#GO:0043226;motile cilium#GO:0031514;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;membrane protein complex#GO:0098796;voltage-gated calcium channel complex#GO:0005891;calcium channel complex#GO:0034704;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;cation channel complex#GO:0034703;CatSper complex#GO:0036128;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 ion channel#PC00133;transporter#PC00227 HUMAN|HGNC=15813|UniProtKB=Q9BZA8 Q9BZA8 PCDH11Y PTHR24028:SF254 CADHERIN-87A PROTOCADHERIN-11 X-LINKED-RELATED cellular process#GO:0009987;cell adhesion#GO:0007155 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HUMAN|HGNC=33767|UniProtKB=Q6ZNM6 Q6ZNM6 SPMIP10 PTHR35247:SF2 TESTIS-EXPRESSED PROTEIN 43 SPERM-ASSOCIATED MICROTUBULE INNER PROTEIN 10 cilium movement involved in cell motility#GO:0060294;sperm motility#GO:0097722;cellular process#GO:0009987;microtubule-based movement#GO:0007018;cell motility#GO:0048870;reproductive process#GO:0022414;flagellated sperm motility#GO:0030317;cilium or flagellum-dependent cell motility#GO:0001539;cilium movement#GO:0003341;cilium-dependent cell motility#GO:0060285;microtubule-based process#GO:0007017 HUMAN|Ensembl=ENSG00000284691.2|UniProtKB=A0A286YF67 A0A286YF67 LOC728743 PTHR24390:SF284 ZINC FINGER PROTEIN EXPRESSED SEQUENCE AI854703 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218 HUMAN|HGNC=44205|UniProtKB=P0DKB6 P0DKB6 MPC1L PTHR14154:SF9 UPF0041 BRAIN PROTEIN 44-RELATED MITOCHONDRIAL PYRUVATE CARRIER 1-LIKE PROTEIN monocarboxylic acid transmembrane transporter activity#GO:0008028;carboxylic acid transmembrane transporter activity#GO:0046943;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 establishment of localization in cell#GO:0051649;cellular process#GO:0009987;carboxylic acid transmembrane transport#GO:1905039;mitochondrial transport#GO:0006839;transport#GO:0006810;carboxylic acid transport#GO:0046942;mitochondrial transmembrane transport#GO:1990542;organic acid transport#GO:0015849;intracellular transport#GO:0046907;monocarboxylic acid transport#GO:0015718;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;transmembrane transport#GO:0055085 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrial inner membrane#GO:0005743;organelle envelope#GO:0031967;membrane#GO:0016020 HUMAN|HGNC=2458|UniProtKB=Q8NEV1 Q8NEV1 CSNK2A3 PTHR24054:SF16 CASEIN KINASE II SUBUNIT ALPHA CASEIN KINASE II SUBUNIT ALPHA-RELATED catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 macromolecule metabolic process#GO:0043170;double-strand break repair#GO:0006302;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA damage response#GO:0006974;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;response to stress#GO:0006950;cellular process#GO:0009987;cellular response to stress#GO:0033554;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of cell cycle#GO:0051726;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789 protein kinase complex#GO:1902911;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;cytosol#GO:0005829;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 Cadherin signaling pathway#P00012>Casein kinase II#P00462;Parkinson disease#P00049>Casein kinase II#P01236;Wnt signaling pathway#P00057>Casein Kinase 2#P01459 HUMAN|HGNC=13626|UniProtKB=P62955 P62955 CACNG7 PTHR12107:SF12 VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA SUBUNIT VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-7 SUBUNIT monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;voltage-gated channel activity#GO:0022832;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;channel activity#GO:0015267;channel regulator activity#GO:0016247;voltage-gated calcium channel activity#GO:0005245;transporter regulator activity#GO:0141108;molecular function regulator activity#GO:0098772;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;passive transmembrane transporter activity#GO:0022803 positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;regulation of biological process#GO:0050789;localization#GO:0051179;regulation of synaptic transmission, glutamatergic#GO:0051966;cell communication#GO:0007154;cellular localization#GO:0051641;positive regulation of signaling#GO:0023056;regulation of biological quality#GO:0065008;positive regulation of synaptic transmission#GO:0050806;localization within membrane#GO:0051668;regulation of signaling#GO:0023051;nervous system process#GO:0050877;multicellular organismal process#GO:0032501;regulation of trans-synaptic signaling#GO:0099177;biological regulation#GO:0065007;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;transmission of nerve impulse#GO:0019226;system process#GO:0003008;regulation of postsynaptic membrane neurotransmitter receptor levels#GO:0099072 asymmetric synapse#GO:0032279;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;postsynapse#GO:0098794;postsynaptic density membrane#GO:0098839;transmembrane transporter complex#GO:1902495;postsynaptic density#GO:0014069;postsynaptic specialization membrane#GO:0099634;postsynaptic membrane#GO:0045211;plasma membrane#GO:0005886;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;neuron to neuron synapse#GO:0098984;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;cell periphery#GO:0071944;membrane#GO:0016020;cell junction#GO:0030054;transporter complex#GO:1990351;signaling receptor complex#GO:0043235;synaptic membrane#GO:0097060 ion channel#PC00133;transporter#PC00227;voltage-gated ion channel#PC00241 HUMAN|HGNC=8319|UniProtKB=Q8NGJ0 Q8NGJ0 OR5A1 PTHR26452:SF354 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5A1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 sensory perception#GO:0007600;nervous system process#GO:0050877;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=15878|UniProtKB=Q9NQ75 Q9NQ75 CASS4 PTHR10654:SF19 CAS SCAFFOLDING PROTEIN CAS SCAFFOLDING PROTEIN FAMILY MEMBER 4 enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;cell motility#GO:0048870;cell migration#GO:0016477;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HUMAN|HGNC=32267|UniProtKB=P0DV76 P0DV76 FAM90A19 PTHR16035:SF14 PROTEIN FAM90A1 PROTEIN FAM90A10-RELATED HUMAN|HGNC=25487|UniProtKB=Q9NWA0 Q9NWA0 MED9 PTHR20844:SF0 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION, SUBUNIT 9 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 9 nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;core mediator complex#GO:0070847;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;mediator complex#GO:0016592;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513 general transcription factor#PC00259;RNA metabolism protein#PC00031 HUMAN|HGNC=17029|UniProtKB=O95905 O95905 ECD PTHR13060:SF0 SGT1 PROTEIN HSGT1 SUPPRESSOR OF GCR2 PROTEIN ECDYSONELESS HOMOLOG transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;transcription coactivator activity#GO:0003713 regulation of RNA metabolic process#GO:0051252;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;positive regulation of RNA metabolic process#GO:0051254;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=1718|UniProtKB=Q9UNH5 Q9UNH5 CDC14A PTHR23339:SF77 TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE DUAL SPECIFICITY PROTEIN PHOSPHATASE CDC14A protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824 cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;plasma membrane bounded cell projection assembly#GO:0120031;cellular component assembly#GO:0022607;regulation of cell cycle process#GO:0010564;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection organization#GO:0120036;positive regulation of cell cycle#GO:0045787;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cell projection assembly#GO:0030031;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;regulation of mitotic cell cycle#GO:0007346;regulation of mitotic cell cycle phase transition#GO:1901990;microtubule cytoskeleton organization#GO:0000226;cilium organization#GO:0044782;organelle assembly#GO:0070925;regulation of cell division#GO:0051302;regulation of cytokinesis#GO:0032465;cell projection organization#GO:0030030;regulation of cellular process#GO:0050794;regulation of cell cycle#GO:0051726;regulation of cell cycle phase transition#GO:1901987;cilium assembly#GO:0060271;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;positive regulation of cell cycle process#GO:0090068 cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;spindle#GO:0005819;centrosome#GO:0005813;intracellular membrane-bounded organelle#GO:0043231;mitotic spindle#GO:0072686;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;organelle lumen#GO:0043233;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HUMAN|HGNC=15607|UniProtKB=Q14155 Q14155 ARHGEF7 PTHR46026:SF3 RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 7 GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 cellular component assembly#GO:0022607;cell projection organization#GO:0030030;plasma membrane bounded cell projection organization#GO:0120036;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;lamellipodium assembly#GO:0030032;cell projection assembly#GO:0030031;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection assembly#GO:0120031 cell leading edge#GO:0031252;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;lamellipodium#GO:0030027 guanyl-nucleotide exchange factor#PC00113;protein-binding activity modulator#PC00095;G-protein modulator#PC00022 HUMAN|HGNC=28337|UniProtKB=Q96LT7 Q96LT7 C9orf72 PTHR31855:SF2 GUANINE NUCLEOTIDE EXCHANGE C9ORF72 GUANINE NUCLEOTIDE EXCHANGE FACTOR C9ORF72 guanyl-nucleotide exchange factor activity#GO:0005085;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 regulation of autophagy#GO:0010506;regulation of biological process#GO:0050789;endocytosis#GO:0006897;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;localization#GO:0051179;regulation of metabolic process#GO:0019222;regulation of TOR signaling#GO:0032006;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;transport#GO:0006810;regulation of response to stimulus#GO:0048583;establishment of localization#GO:0051234;import into cell#GO:0098657;regulation of catabolic process#GO:0009894;regulation of TORC1 signaling#GO:1903432 autophagosome#GO:0005776;endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;intracellular vesicle#GO:0097708;vesicle#GO:0031982;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;vacuole#GO:0005773 HUMAN|HGNC=1187|UniProtKB=Q9UKR5 Q9UKR5 ERG28 PTHR15451:SF19 ERGOSTEROL BIOSYNTHETIC PROTEIN 28-RELATED ERGOSTEROL BIOSYNTHETIC PROTEIN 28 HOMOLOG molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 HUMAN|HGNC=18216|UniProtKB=Q8WXS4 Q8WXS4 TMEM37 PTHR31767:SF0 VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-LIKE SUBUNIT VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-LIKE SUBUNIT voltage-gated ion channel#PC00241 HUMAN|HGNC=16746|UniProtKB=Q5VZF2 Q5VZF2 MBNL2 PTHR12675:SF4 MUSCLEBLIND-LIKE PROTEIN MUSCLEBLIND-LIKE PROTEIN 2 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 RNA splicing factor#PC00148;RNA processing factor#PC00147 HUMAN|HGNC=6201|UniProtKB=O76095 O76095 JTB PTHR13041:SF3 JTB PROTEIN-RELATED PROTEIN JTB mitotic cell cycle process#GO:1903047;cytoskeleton-dependent cytokinesis#GO:0061640;cytokinesis#GO:0000910;mitotic cytokinesis#GO:0000281;mitotic cell cycle#GO:0000278;cell cycle process#GO:0022402;cell division#GO:0051301;cellular process#GO:0009987;cell cycle#GO:0007049 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;spindle#GO:0005819;microtubule organizing center#GO:0005815;centrosome#GO:0005813;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microtubule cytoskeleton#GO:0015630;midbody#GO:0030496 HUMAN|HGNC=6075|UniProtKB=O15327 O15327 INPP4B PTHR12187:SF3 AGAP000124-PA INOSITOL POLYPHOSPHATE 4-PHOSPHATASE TYPE II hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051896;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;regulation of cell communication#GO:0010646;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;membrane#GO:0016020 phosphatase#PC00181 HUMAN|HGNC=18249|UniProtKB=Q719H9 Q719H9 KCTD1 PTHR14499:SF65 POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD1 transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714;transcription regulator activity#GO:0140110 negative regulation of metabolic process#GO:0009892;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 scaffold/adaptor protein#PC00226 HUMAN|HGNC=10668|UniProtKB=Q86UR1 Q86UR1 NOXA1 PTHR15175:SF4 NEUTROPHIL CYTOSOLIC FACTOR 2, NEUTROPHIL NADPH OXIDASE FACTOR 2 NADPH OXIDASE ACTIVATOR 1 enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047 biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular process#GO:0009987;regulation of metabolic process#GO:0019222;superoxide metabolic process#GO:0006801;regulation of reactive oxygen species metabolic process#GO:2000377;metabolic process#GO:0008152;reactive oxygen species metabolic process#GO:0072593 membrane#GO:0016020;oxidoreductase complex#GO:1990204;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;catalytic complex#GO:1902494 protein-binding activity modulator#PC00095 HUMAN|HGNC=1734|UniProtKB=P49427 P49427 CDC34 PTHR24067:SF135 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2 R1 ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein conjugating enzyme activity#GO:0061650;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;ubiquitin conjugating enzyme activity#GO:0061631;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824 macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein modification by small protein conjugation or removal#GO:0070647;catabolic process#GO:0009056;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;protein modification process#GO:0036211;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;protein K48-linked ubiquitination#GO:0070936;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;proteasomal protein catabolic process#GO:0010498;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=23448|UniProtKB=B1AL46 B1AL46 NUTM2E PTHR22879:SF14 NUT FAMILY MEMBER 1 NUT FAMILY MEMBER 2A-RELATED HUMAN|HGNC=24852|UniProtKB=Q9P107 Q9P107 GMIP PTHR15228:SF16 SPERMATHECAL PHYSIOLOGY VARIANT GEM-INTERACTING PROTEIN enzyme activator activity#GO:0008047;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of cell communication#GO:0010646;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;intracellular signal transduction#GO:0035556;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;negative regulation of response to stimulus#GO:0048585;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of small GTPase mediated signal transduction#GO:0051056;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583 GTPase-activating protein#PC00257;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HUMAN|HGNC=2435|UniProtKB=P15509 P15509 CSF2RA PTHR23036:SF190 CYTOKINE RECEPTOR GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR RECEPTOR SUBUNIT ALPHA binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;protein binding#GO:0005515;cytokine receptor activity#GO:0004896;immune receptor activity#GO:0140375;signaling receptor activity#GO:0038023;cytokine binding#GO:0019955 negative regulation of apoptotic process#GO:0043066;response to chemical#GO:0042221;response to cytokine#GO:0034097;biological regulation#GO:0065007;regulation of neuron apoptotic process#GO:0043523;negative regulation of neuron apoptotic process#GO:0043524;negative regulation of programmed cell death#GO:0043069;positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;negative regulation of cellular process#GO:0048523;cell surface receptor signaling pathway#GO:0007166;regulation of apoptotic process#GO:0042981;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;positive regulation of cell population proliferation#GO:0008284;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;response to peptide#GO:1901652;cytokine-mediated signaling pathway#GO:0019221 extracellular protein-containing complex#GO:0140392;extracellular region#GO:0005576;signaling receptor complex#GO:0043235;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=17177|UniProtKB=Q8IUI8 Q8IUI8 CRLF3 PTHR23389:SF12 CHROMOSOME TRANSMISSION FIDELITY FACTOR 18 CYTOKINE RECEPTOR-LIKE FACTOR 3 DNA binding#GO:0003677;binding#GO:0005488;nucleic acid binding#GO:0003676 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 DNA metabolism protein#PC00009 HUMAN|HGNC=2690|UniProtKB=P07108 P07108 DBI PTHR23310:SF54 ACYL-COA-BINDING PROTEIN, ACBP ACYL-COA-BINDING PROTEIN nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;binding#GO:0005488;lipid binding#GO:0008289;heterocyclic compound binding#GO:1901363 metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;fatty acid metabolic process#GO:0006631;lipid metabolic process#GO:0006629;small molecule metabolic process#GO:0044281;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;cellular process#GO:0009987 transfer/carrier protein#PC00219 HUMAN|HGNC=28732|UniProtKB=P0C862 P0C862 C1QTNF9 PTHR15427:SF21 EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER COMPLEMENT C1Q AND TUMOR NECROSIS FACTOR-RELATED PROTEIN 9A receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677;hormone activity#GO:0005179 cellular process#GO:0009987;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;small molecule metabolic process#GO:0044281;fatty acid oxidation#GO:0019395;lipid metabolic process#GO:0006629;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;lipid modification#GO:0030258;lipid oxidation#GO:0034440 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 scaffold/adaptor protein#PC00226 HUMAN|HGNC=16437|UniProtKB=Q9BX51 Q9BX51 GGTLC1 PTHR45027:SF4 PUTATIVE GLUTATHIONE HYDROLASE LIGHT CHAIN GLUTATHIONE HYDROLASE LIGHT CHAIN 1 hydrolase#PC00121 HUMAN|HGNC=6269|UniProtKB=Q15842 Q15842 KCNJ8 PTHR11767:SF11 INWARD RECTIFIER POTASSIUM CHANNEL ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 8 channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;potassium channel activity#GO:0005267;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215 localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;import across plasma membrane#GO:0098739;metal ion transport#GO:0030001;inorganic ion import across plasma membrane#GO:0099587;potassium ion import across plasma membrane#GO:1990573;establishment of localization#GO:0051234;import into cell#GO:0098657;inorganic cation import across plasma membrane#GO:0098659;transport#GO:0006810;potassium ion transport#GO:0006813;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133 HUMAN|HGNC=23683|UniProtKB=Q92928 Q92928 RAB1C PTHR24073:SF1105 DRAB5-RELATED RAS-RELATED PROTEIN RAB-1C-RELATED catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111 cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;autophagosome assembly#GO:0000045;metabolic process#GO:0008152;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810;cellular component assembly#GO:0022607;macroautophagy#GO:0016236;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;macromolecule localization#GO:0033036;establishment of localization in cell#GO:0051649;autophagy#GO:0006914;establishment of protein localization#GO:0045184;cellular process#GO:0009987;autophagosome organization#GO:1905037;localization#GO:0051179;cellular localization#GO:0051641;vacuole organization#GO:0007033;process utilizing autophagic mechanism#GO:0061919;protein transport#GO:0015031;organelle assembly#GO:0070925;catabolic process#GO:0009056;cellular component organization#GO:0016043 cell body#GO:0044297;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;somatodendritic compartment#GO:0036477;neuronal cell body#GO:0043025;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 G-protein#PC00020;small GTPase#PC00208 HUMAN|HGNC=23621|UniProtKB=Q7L4E1 Q7L4E1 MIGA2 PTHR21508:SF4 MITOGUARDIN MITOGUARDIN 2 organelle fusion#GO:0048284;cellular component organization or biogenesis#GO:0071840;mitochondrion organization#GO:0007005;cellular component organization#GO:0016043;mitochondrial fusion#GO:0008053;organelle organization#GO:0006996;cellular process#GO:0009987 HUMAN|HGNC=1441|UniProtKB=Q05682 Q05682 CALD1 PTHR18949:SF0 CALDESMON CALDESMON protein binding#GO:0005515;myosin binding#GO:0017022;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779 actin filament-based process#GO:0030029;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cellular component organization or biogenesis#GO:0071840;actin filament bundle assembly#GO:0051017;cellular process#GO:0009987;actin filament bundle organization#GO:0061572;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular component organization#GO:0016043;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;actin cytoskeleton organization#GO:0030036 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;actin cytoskeleton#GO:0015629;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226 non-motor actin binding protein#PC00165 HUMAN|HGNC=34407|UniProtKB=Q2L4Q9 Q2L4Q9 PRSS53 PTHR24276:SF61 POLYSERASE-RELATED SERINE PROTEASE 53 serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;serine-type peptidase activity#GO:0008236;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;catalytic activity#GO:0003824 serine protease#PC00203;protein modifying enzyme#PC00260 HUMAN|HGNC=2482|UniProtKB=P04080 P04080 CSTB PTHR11414:SF22 CYSTATIN FAMILY MEMBER CYSTATIN-B cysteine-type endopeptidase inhibitor activity#GO:0004869;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;peptidase regulator activity#GO:0061134;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414;molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866;enzyme inhibitor activity#GO:0004857 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protease inhibitor#PC00191;protein-binding activity modulator#PC00095 HUMAN|HGNC=32326|UniProtKB=Q9UPX0 Q9UPX0 IGSF9B PTHR12231:SF240 CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN PROTEIN TURTLE HOMOLOG B cell adhesion mediator activity#GO:0098631;cell adhesion molecule binding#GO:0050839;binding#GO:0005488;protein binding#GO:0005515 cellular process#GO:0009987;cell adhesion#GO:0007155;cell-cell adhesion#GO:0098609;homophilic cell-cell adhesion#GO:0007156 cell junction#GO:0030054;synaptic membrane#GO:0097060;plasma membrane region#GO:0098590;postsynaptic specialization#GO:0099572;neuron to neuron synapse#GO:0098984;plasma membrane#GO:0005886;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;postsynaptic membrane#GO:0045211;postsynaptic density#GO:0014069;asymmetric synapse#GO:0032279;organelle#GO:0043226;cellular anatomical structure#GO:0110165;synapse#GO:0045202;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;postsynapse#GO:0098794 immunoglobulin superfamily cell adhesion molecule#PC00125;cell adhesion molecule#PC00069 HUMAN|HGNC=3677|UniProtKB=Q9NP95 Q9NP95 FGF20 PTHR11486:SF72 FIBROBLAST GROWTH FACTOR FIBROBLAST GROWTH FACTOR 20 protein binding#GO:0005515;molecular function activator activity#GO:0140677;binding#GO:0005488;signaling receptor binding#GO:0005102;fibroblast growth factor receptor binding#GO:0005104;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;growth factor receptor binding#GO:0070851;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;growth factor activity#GO:0008083 system development#GO:0048731;regulation of cell population proliferation#GO:0042127;cell communication#GO:0007154;regulation of cell motility#GO:2000145;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of cell communication#GO:0010646;response to growth factor#GO:0070848;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;positive regulation of MAPK cascade#GO:0043410;developmental process#GO:0032502;positive regulation of intracellular signal transduction#GO:1902533;regulation of cell migration#GO:0030334;regulation of response to stimulus#GO:0048583;response to fibroblast growth factor#GO:0071774;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of locomotion#GO:0040012;positive regulation of response to stimulus#GO:0048584;fibroblast growth factor receptor signaling pathway#GO:0008543;multicellular organismal process#GO:0032501;positive regulation of cellular process#GO:0048522;cellular response to growth factor stimulus#GO:0071363;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;animal gross anatomical part developmental process#GO:0160108;regulation of intracellular signal transduction#GO:1902531;signaling#GO:0023052;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;cell differentiation#GO:0030154;regulation of biological process#GO:0050789;positive regulation of cell population proliferation#GO:0008284;response to endogenous stimulus#GO:0009719;multicellular organism development#GO:0007275;regulation of MAPK cascade#GO:0043408;cell surface receptor signaling pathway#GO:0007166;nervous system development#GO:0007399;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular response to fibroblast growth factor stimulus#GO:0044344;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207;growth factor#PC00112 FGF signaling pathway#P00021>FGF#P00623 HUMAN|HGNC=4036|UniProtKB=O15117 O15117 FYB1 PTHR16830:SF13 SH2 CONTAINING ADAPTOR PRAM-1 RELATED FYN-BINDING PROTEIN 1 localization#GO:0051179;cell communication#GO:0007154;localization within membrane#GO:0051668;regulation of immune response#GO:0050776;immune response-activating cell surface receptor signaling pathway#GO:0002429;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;protein localization to plasma membrane#GO:0072659;intracellular protein localization#GO:0008104;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;T cell receptor signaling pathway#GO:0050852;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;positive regulation of response to stimulus#GO:0048584;macromolecule localization#GO:0033036;cellular localization#GO:0051641;immune system process#GO:0002376;signaling#GO:0023052;response to stimulus#GO:0050896;immune response-regulating signaling pathway#GO:0002764;regulation of biological process#GO:0050789;integrin-mediated signaling pathway#GO:0007229;protein localization to membrane#GO:0072657;immune response-activating signaling pathway#GO:0002757;cell surface receptor signaling pathway#GO:0007166;protein localization to cell periphery#GO:1990778;antigen receptor-mediated signaling pathway#GO:0050851;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;positive regulation of immune system process#GO:0002684 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HUMAN|HGNC=9416|UniProtKB=Q13237 Q13237 PRKG2 PTHR24353:SF24 CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE SUBFAMILY NOT NAMED cell communication#GO:0007154;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 Endothelin signaling pathway#P00019>PKG#P00567 HUMAN|HGNC=553|UniProtKB=Q06278 Q06278 AOX1 PTHR11908:SF86 XANTHINE DEHYDROGENASE ALDEHYDE OXIDASE oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the aldehyde or oxo group of donors#GO:0016903;catalytic activity#GO:0003824 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=9890|UniProtKB=Q16576 Q16576 RBBP7 PTHR22850:SF82 WD40 REPEAT FAMILY HISTONE-BINDING PROTEIN RBBP7 histone binding#GO:0042393;binding#GO:0005488;protein binding#GO:0005515 cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;chromatin remodeling#GO:0006338;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;chromatin organization#GO:0006325;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;transcription regulator complex#GO:0005667;transferase complex#GO:1990234;histone methyltransferase complex#GO:0035097;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;PcG protein complex#GO:0031519;histone deacetylase complex#GO:0000118;membrane-enclosed lumen#GO:0031974;chromatin#GO:0000785;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ATPase complex#GO:1904949;methyltransferase complex#GO:0034708;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;chromosome#GO:0005694;SWI/SNF superfamily-type complex#GO:0070603 HUMAN|HGNC=20582|UniProtKB=Q7Z449 Q7Z449 CYP2U1 PTHR24300:SF364 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 2U1 binding#GO:0005488;steroid hydroxylase activity#GO:0008395;tetrapyrrole binding#GO:0046906;heme binding#GO:0020037;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824;monooxygenase activity#GO:0004497;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen#GO:0016712 lipid metabolic process#GO:0006629;cellular response to chemical stimulus#GO:0070887;metabolic process#GO:0008152;response to xenobiotic stimulus#GO:0009410;cellular response to xenobiotic stimulus#GO:0071466;xenobiotic metabolic process#GO:0006805;steroid metabolic process#GO:0008202;response to chemical#GO:0042221;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;primary metabolic process#GO:0044238 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 oxygenase#PC00177;oxidoreductase#PC00176 HUMAN|HGNC=13667|UniProtKB=Q9BXS5 Q9BXS5 AP1M1 PTHR10529:SF257 AP COMPLEX SUBUNIT MU AP-1 COMPLEX SUBUNIT MU-1 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;cargo adaptor activity#GO:0140312 cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;transport#GO:0006810;Golgi vesicle transport#GO:0048193;vacuolar transport#GO:0007034;intracellular transport#GO:0046907;post-Golgi vesicle-mediated transport#GO:0006892;cellular localization#GO:0051641;establishment of localization#GO:0051234;Golgi to vacuole transport#GO:0006896;localization#GO:0051179 coated vesicle#GO:0030135;organelle subcompartment#GO:0031984;coated membrane#GO:0048475;intracellular organelle#GO:0043229;coated vesicle membrane#GO:0030662;Golgi-associated vesicle membrane#GO:0030660;clathrin coat#GO:0030118;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular vesicle#GO:0097708;bounding membrane of organelle#GO:0098588;AP-type membrane coat adaptor complex#GO:0030119;clathrin-coated vesicle membrane#GO:0030665;clathrin vesicle coat#GO:0030125;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;vesicle coat#GO:0030120;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;membrane coat#GO:0030117;AP-1 adaptor complex#GO:0030121;trans-Golgi network transport vesicle#GO:0030140;intracellular membrane-bounded organelle#GO:0043231;vesicle#GO:0031982;membrane protein complex#GO:0098796;organelle membrane#GO:0031090;clathrin-coated vesicle#GO:0030136;Golgi-associated vesicle#GO:0005798;Golgi apparatus#GO:0005794;trans-Golgi network transport vesicle membrane#GO:0012510;endomembrane system#GO:0012505;transport vesicle membrane#GO:0030658;transport vesicle#GO:0030133;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;vesicle membrane#GO:0012506 membrane traffic protein#PC00150 HUMAN|HGNC=10901|UniProtKB=Q13309 Q13309 SKP2 PTHR16134:SF32 F-BOX/TPR REPEAT PROTEIN POF3 S-PHASE KINASE-ASSOCIATED PROTEIN 2 ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;regulation of response to stimulus#GO:0048583;regulation of DNA repair#GO:0006282;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;regulation of response to stress#GO:0080134;biological regulation#GO:0065007;positive regulation of DNA repair#GO:0045739;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of response to stimulus#GO:0048584;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of double-strand break repair#GO:2000779;protein metabolic process#GO:0019538;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;positive regulation of double-strand break repair#GO:2000781;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;modification-dependent protein catabolic process#GO:0019941;positive regulation of DNA metabolic process#GO:0051054;primary metabolic process#GO:0044238;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasomal protein catabolic process#GO:0010498;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of cellular response to stress#GO:0080135;positive regulation of metabolic process#GO:0009893;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;regulation of DNA recombination#GO:0000018;regulation of double-strand break repair via homologous recombination#GO:0010569;regulation of biological process#GO:0050789;regulation of DNA metabolic process#GO:0051052 catalytic complex#GO:1902494;transferase complex#GO:1990234;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535;SCF ubiquitin ligase complex#GO:0019005;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=32464|UniProtKB=A6NN14 A6NN14 ZNF729 PTHR24376:SF154 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 208-RELATED C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=10073|UniProtKB=O60942 O60942 RNGTT PTHR10367:SF17 MRNA-CAPPING ENZYME MRNA-CAPPING ENZYME catalytic activity, acting on RNA#GO:0140098;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640 macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 RNA processing factor#PC00147;mRNA capping factor#PC00145 HUMAN|HGNC=1688|UniProtKB=P19256 P19256 CD58 PTHR12080:SF150 SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN 3 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 multicellular organismal process#GO:0032501;lymphocyte activation#GO:0046649;biological regulation#GO:0065007;cellular process#GO:0009987;immune response#GO:0006955;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;T cell activation#GO:0042110;leukocyte activation#GO:0045321;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cell communication#GO:0007154;immune system process#GO:0002376;cell activation#GO:0001775 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=10630|UniProtKB=P13236 P13236 CCL4 PTHR12015:SF215 SMALL INDUCIBLE CYTOKINE A C-C MOTIF CHEMOKINE 4 chemokine receptor binding#GO:0042379;protein binding#GO:0005515;molecular function activator activity#GO:0140677;binding#GO:0005488;cytokine receptor binding#GO:0005126;signaling receptor binding#GO:0005102;cytokine activity#GO:0005125;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;chemokine activity#GO:0008009;G protein-coupled receptor binding#GO:0001664 positive regulation of cell migration#GO:0030335;positive regulation of cellular process#GO:0048522;immune response#GO:0006955;cell migration#GO:0016477;response to other organism#GO:0051707;regulation of locomotion#GO:0040012;biological regulation#GO:0065007;leukocyte migration#GO:0050900;regulation of cell migration#GO:0030334;leukocyte chemotaxis#GO:0030595;defense response#GO:0006952;response to external stimulus#GO:0009605;myeloid leukocyte migration#GO:0097529;positive regulation of locomotion#GO:0040017;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;cell motility#GO:0048870;locomotion#GO:0040011;cellular response to chemokine#GO:1990869;response to external biotic stimulus#GO:0043207;cytokine-mediated signaling pathway#GO:0019221;inflammatory response#GO:0006954;chemotaxis#GO:0006935;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;cell communication#GO:0007154;regulation of cell motility#GO:2000145;chemokine-mediated signaling pathway#GO:0070098;cell chemotaxis#GO:0060326;response to stress#GO:0006950;response to chemokine#GO:1990868;response to biotic stimulus#GO:0009607;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;defense response to symbiont#GO:0140546;signal transduction#GO:0007165;defense response to other organism#GO:0098542;granulocyte migration#GO:0097530;taxis#GO:0042330;response to chemical#GO:0042221;response to cytokine#GO:0034097;antimicrobial humoral response#GO:0019730;humoral immune response#GO:0006959;cell surface receptor signaling pathway#GO:0007166;positive regulation of cell motility#GO:2000147;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;granulocyte chemotaxis#GO:0071621;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;G protein-coupled receptor signaling pathway#GO:0007186;immune system process#GO:0002376;cellular response to chemical stimulus#GO:0070887;response to peptide#GO:1901652 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 cytokine#PC00083 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CHK#P00856 HUMAN|HGNC=25165|UniProtKB=Q6NUI6 Q6NUI6 CHADL PTHR24373:SF284 SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN CHONDROADHERIN-LIKE PROTEIN molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=9751|UniProtKB=P47897 P47897 QARS1 PTHR43097:SF16 GLUTAMINE-TRNA LIGASE GLUTAMINE--TRNA LIGASE catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;ligase activity#GO:0016874;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a tRNA#GO:0140101 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;protein biosynthetic process#GO:0160307;translation#GO:0006412;protein metabolic process#GO:0019538;RNA metabolic process#GO:0016070;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;tRNA aminoacylation for protein translation#GO:0006418;tRNA aminoacylation#GO:0043039;amino acid metabolic process#GO:0006520;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;amino acid activation#GO:0043038;macromolecule metabolic process#GO:0043170 cytosol#GO:0005829;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular protein-containing complex#GO:0140535;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 aminoacyl-tRNA synthetase#PC00047 Heme biosynthesis#P02746>Glutamyl-tRNA-synthetase#P02977 HUMAN|HGNC=22939|UniProtKB=Q86W24 Q86W24 NLRP14 PTHR45690:SF15 NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12 NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 14 regulation of response to external stimulus#GO:0032101;biological regulation#GO:0065007;regulation of response to stress#GO:0080134;regulation of biological process#GO:0050789;regulation of response to stimulus#GO:0048583;regulation of defense response#GO:0031347;regulation of inflammatory response#GO:0050727 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 defense/immunity protein#PC00090 HUMAN|HGNC=29255|UniProtKB=Q70EK8 Q70EK8 USP53 PTHR22975:SF6 UBIQUITIN SPECIFIC PROTEINASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 53 system process#GO:0003008;response to external stimulus#GO:0009605;nervous system process#GO:0050877;sensory perception of mechanical stimulus#GO:0050954;sensory perception#GO:0007600;multicellular organismal process#GO:0032501;response to stimulus#GO:0050896;sensory perception of sound#GO:0007605;response to mechanical stimulus#GO:0009612;response to abiotic stimulus#GO:0009628 cell-cell junction#GO:0005911;anchoring junction#GO:0070161;cell junction#GO:0030054;cellular anatomical structure#GO:0110165 protease#PC00190;cysteine protease#PC00081;protein modifying enzyme#PC00260 HUMAN|HGNC=31749|UniProtKB=Q8WW36 Q8WW36 ZCCHC13 PTHR23002:SF53 ZINC FINGER CCHC DOMAIN CONTAINING PROTEIN ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 13 RNA binding#GO:0003723;single-stranded RNA binding#GO:0003727;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729 regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of protein metabolic process#GO:0051247;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of translation#GO:0045727;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;regulation of macromolecule biosynthetic process#GO:0010556;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604;biological regulation#GO:0065007;post-transcriptional regulation of gene expression#GO:0010608;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of gene expression#GO:0010628 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031 HUMAN|HGNC=24903|UniProtKB=Q9Y520 Q9Y520 PRRC2C PTHR14038:SF6 BAT2 HLA-B-ASSOCIATED TRANSCRIPT 2 PROTEIN PRRC2C nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cytoplasmic stress granule assembly#GO:0034063;cellular component assembly#GO:0022607 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031 HUMAN|HGNC=11847|UniProtKB=Q15399 Q15399 TLR1 PTHR24365:SF261 TOLL-LIKE RECEPTOR TOLL-LIKE RECEPTOR 1 lipid binding#GO:0008289;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488 positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;response to other organism#GO:0051707;activation of innate immune response#GO:0002218;positive regulation of innate immune response#GO:0045089;regulation of innate immune response#GO:0045088;cellular response to molecule of bacterial origin#GO:0071219;response to external stimulus#GO:0009605;positive regulation of response to biotic stimulus#GO:0002833;pattern recognition receptor signaling pathway#GO:0002221;regulation of response to stress#GO:0080134;positive regulation of immune response#GO:0050778;positive regulation of defense response#GO:0031349;regulation of response to stimulus#GO:0048583;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;response to external biotic stimulus#GO:0043207;regulation of response to biotic stimulus#GO:0002831;innate immune response-activating signaling pathway#GO:0002758;cellular response to biotic stimulus#GO:0071216;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;response to bacterium#GO:0009617;regulation of immune response#GO:0050776;regulation of defense response#GO:0031347;regulation of response to external stimulus#GO:0032101;response to biotic stimulus#GO:0009607;positive regulation of immune system process#GO:0002684;signal transduction#GO:0007165;activation of immune response#GO:0002253;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;immune response-activating signaling pathway#GO:0002757;positive regulation of response to external stimulus#GO:0032103;response to stimulus#GO:0050896;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;toll-like receptor signaling pathway#GO:0002224;regulation of biological process#GO:0050789;response to molecule of bacterial origin#GO:0002237;immune response-regulating signaling pathway#GO:0002764;immune system process#GO:0002376 signaling receptor complex#GO:0043235;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797 transmembrane signal receptor#PC00197 Toll receptor signaling pathway#P00054>TLR1,2,6#P01380;Toll receptor signaling pathway#P00054>TLR#P01346 HUMAN|HGNC=2068|UniProtKB=P49759 P49759 CLK1 PTHR45646:SF4 SERINE/THREONINE-PROTEIN KINASE DOA-RELATED DUAL SPECIFICITY PROTEIN KINASE CLK1 transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA splicing#GO:0043484;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=6176|UniProtKB=Q9BY32 Q9BY32 ITPA PTHR11067:SF9 INOSINE TRIPHOSPHATE PYROPHOSPHATASE/HAM1 PROTEIN INOSINE TRIPHOSPHATE PYROPHOSPHATASE hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;nucleoside triphosphate diphosphatase activity#GO:0047429;hydrolase activity#GO:0016787 nucleobase-containing compound metabolic process#GO:0006139;nucleoside phosphate metabolic process#GO:0006753;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;nucleoside phosphate catabolic process#GO:1901292;purine nucleoside triphosphate metabolic process#GO:0009144;cellular process#GO:0009987;nucleobase-containing compound catabolic process#GO:0034655;organophosphate metabolic process#GO:0019637;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;nucleobase-containing small molecule metabolic process#GO:0055086;organophosphate catabolic process#GO:0046434;metabolic process#GO:0008152 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 nucleotide phosphatase#PC00173 HUMAN|HGNC=30583|UniProtKB=Q5VXH4 Q5VXH4 PRAMEF6 PTHR14224:SF112 SIMILAR TO PREFERENTIALLY EXPRESSED ANTIGEN IN MELANOMA-LIKE 3 PRAME FAMILY MEMBER 11-RELATED ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056 transferase complex#GO:1990234;catalytic complex#GO:1902494;Cul2-RING ubiquitin ligase complex#GO:0031462;ubiquitin ligase complex#GO:0000151;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cullin-RING ubiquitin ligase complex#GO:0031461;cytoplasm#GO:0005737 HUMAN|HGNC=10056|UniProtKB=Q9Y3C5 Q9Y3C5 RNF11 PTHR46359:SF1 GEO07743P1 RING FINGER PROTEIN 11 ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;catabolic process#GO:0009056;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987 intracellular protein-containing complex#GO:0140535;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;transferase complex#GO:1990234 HUMAN|HGNC=29543|UniProtKB=B1AK76 B1AK76 SNURFL PTHR14508:SF2 SNRPN UPSTREAM READING FRAME PROTEIN, SNURF SNRPN UPSTREAM READING FRAME PROTEIN-RELATED ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;nuclear body#GO:0016604;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membraneless organelle#GO:0043228;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear speck#GO:0016607;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 HUMAN|HGNC=4983|UniProtKB=P09429 P09429 HMGB1 PTHR48112:SF11 HIGH MOBILITY GROUP PROTEIN DSP1 HIGH MOBILITY GROUP PROTEIN B1 cellular process#GO:0009987;cellular component organization#GO:0016043;chromatin organization#GO:0006325;chromatin remodeling#GO:0006338;cellular component organization or biogenesis#GO:0071840 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HMG box transcription factor#PC00024;gene-specific transcriptional regulator#PC00264 p53 pathway#P00059>HMG1#P04619 HUMAN|HGNC=33258|UniProtKB=B7Z6K7 B7Z6K7 ZNF814 PTHR24376:SF258 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 814 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=1911|UniProtKB=Q13112 Q13112 CHAF1B PTHR15271:SF4 CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B protein-containing complex organization#GO:0043933;protein-DNA complex organization#GO:0071824;cellular component organization or biogenesis#GO:0071840;nucleosome organization#GO:0034728;protein-DNA complex assembly#GO:0065004;chromatin organization#GO:0006325;chromatin remodeling#GO:0006338;cellular component assembly#GO:0022607;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=4112|UniProtKB=Q96GT9 Q96GT9 XAGE2 PTHR14047:SF33 P ANTIGEN FAMILY MEMBER 5-RELATED X ANTIGEN FAMILY MEMBER 2 HUMAN|HGNC=2288|UniProtKB=P14406 P14406 COX7A2 PTHR10510:SF17 CYTOCHROME C OXIDASE POLYPEPTIDE 7A CYTOCHROME C OXIDASE SUBUNIT 7A2, MITOCHONDRIAL protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 energy derivation by oxidation of organic compounds#GO:0015980;cellular respiration#GO:0045333;oxidative phosphorylation#GO:0006119;aerobic respiration#GO:0009060;metabolic process#GO:0008152;cellular process#GO:0009987;generation of precursor metabolites and energy#GO:0006091 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;respiratory chain complex#GO:0098803;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;mitochondrial envelope#GO:0005740;organelle envelope#GO:0031967;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 oxidase#PC00175;oxidoreductase#PC00176 HUMAN|HGNC=17019|UniProtKB=Q96MT3 Q96MT3 PRICKLE1 PTHR24211:SF15 LIM DOMAIN-CONTAINING PROTEIN PRICKLE-LIKE PROTEIN 1 nucleocytoplasmic transport#GO:0006913;embryo development ending in birth or egg hatching#GO:0009792;system development#GO:0048731;nuclear transport#GO:0051169;anatomical structure development#GO:0048856;tissue morphogenesis#GO:0048729;localization#GO:0051179;tube morphogenesis#GO:0035239;establishment of cell polarity#GO:0030010;protein localization to organelle#GO:0033365;cell motility#GO:0048870;transport#GO:0006810;developmental process#GO:0032502;intracellular transport#GO:0046907;neurogenesis#GO:0022008;intracellular protein localization#GO:0008104;cellular developmental process#GO:0048869;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;protein localization to nucleus#GO:0034504;import into nucleus#GO:0051170;macromolecule localization#GO:0033036;tube development#GO:0035295;plasma membrane bounded cell projection organization#GO:0120036;cell migration#GO:0016477;multicellular organismal process#GO:0032501;tissue development#GO:0009888;epithelium development#GO:0060429;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;chordate embryonic development#GO:0043009;establishment or maintenance of cell polarity#GO:0007163;protein import into nucleus#GO:0006606;protein transport#GO:0015031;neuron development#GO:0048666;cellular localization#GO:0051641;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;cell development#GO:0048468;cell projection organization#GO:0030030;cell differentiation#GO:0030154;intracellular protein transport#GO:0006886;neuron differentiation#GO:0030182;anatomical structure formation involved in morphogenesis#GO:0048646;morphogenesis of an epithelium#GO:0002009;multicellular organism development#GO:0007275;embryonic morphogenesis#GO:0048598;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;neuron projection development#GO:0031175;nervous system development#GO:0007399;embryo development#GO:0009790 plasma membrane#GO:0005886;neuron to neuron synapse#GO:0098984;postsynaptic specialization#GO:0099572;nucleus#GO:0005634;cell periphery#GO:0071944;membrane#GO:0016020;cell junction#GO:0030054;intracellular membrane-bounded organelle#GO:0043231;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;asymmetric synapse#GO:0032279;postsynapse#GO:0098794;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;postsynaptic density#GO:0014069;intracellular organelle#GO:0043229 scaffold/adaptor protein#PC00226 HUMAN|HGNC=17025|UniProtKB=Q96P44 Q96P44 COL21A1 PTHR24020:SF90 COLLAGEN ALPHA COLLAGEN ALPHA-1(XXI) CHAIN extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cellular anatomical structure#GO:0110165 extracellular matrix structural protein#PC00103 HUMAN|HGNC=16712|UniProtKB=Q969H0 Q969H0 FBXW7 PTHR19849:SF1 PHOSPHOLIPASE A-2-ACTIVATING PROTEIN F-BOX_WD REPEAT-CONTAINING PROTEIN 7 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;cellular process#GO:0009987;autophagy#GO:0006914;proteasomal protein catabolic process#GO:0010498;macroautophagy#GO:0016236;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;process utilizing autophagic mechanism#GO:0061919;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 ubiquitin-protein ligase#PC00234 Notch signaling pathway#P00045>Sel 10#P01102;Parkinson disease#P00049>hSel10#P01240 HUMAN|HGNC=584|UniProtKB=P02743 P02743 APCS PTHR45869:SF5 C-REACTIVE PROTEIN-RELATED SERUM AMYLOID P-COMPONENT complement binding#GO:0001848;binding#GO:0005488;protein binding#GO:0005515;protein-containing complex binding#GO:0044877 innate immune response#GO:0045087;defense response#GO:0006952;acute inflammatory response#GO:0002526;response to external stimulus#GO:0009605;immune system process#GO:0002376;inflammatory response#GO:0006954;defense response to other organism#GO:0098542;response to stimulus#GO:0050896;response to other organism#GO:0051707;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;immune response#GO:0006955;defense response to symbiont#GO:0140546 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=10990|UniProtKB=P12235 P12235 SLC25A4 PTHR45635:SF32 ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED ADP_ATP TRANSLOCASE 1 organophosphate ester transmembrane transporter activity#GO:0015605;nucleobase-containing compound transmembrane transporter activity#GO:0015932;carbohydrate derivative transmembrane transporter activity#GO:1901505;antiporter activity#GO:0015297;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;purine nucleotide transmembrane transporter activity#GO:0015216;active transmembrane transporter activity#GO:0022804 regulation of biological quality#GO:0065008;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;transport#GO:0006810;biological regulation#GO:0065007;regulation of mitochondrial membrane permeability#GO:0046902;regulation of membrane permeability#GO:0090559;organophosphate ester transport#GO:0015748;nucleobase-containing compound transport#GO:0015931;carbohydrate derivative transport#GO:1901264;cellular process#GO:0009987;nitrogen compound transport#GO:0071705 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;organelle membrane#GO:0031090;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;organelle envelope#GO:0031967;membrane protein complex#GO:0098796;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 transfer/carrier protein#PC00219 HUMAN|HGNC=24609|UniProtKB=P08217 P08217 CELA2A PTHR24257:SF24 CHYMOTRYPSIN-LIKE ELASTASE FAMILY MEMBER CHYMOTRYPSIN-LIKE ELASTASE FAMILY MEMBER 2A hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;serine-type peptidase activity#GO:0008236;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity#GO:0003824 catabolic process#GO:0009056;regulation of cellular process#GO:0050794;regulation of cell-cell adhesion#GO:0022407;regulation of biological process#GO:0050789;regulation of cell activation#GO:0050865;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;regulation of platelet activation#GO:0010543;proteolysis#GO:0006508;regulation of platelet aggregation#GO:0090330;biological regulation#GO:0065007;regulation of multicellular organismal process#GO:0051239;regulation of cell adhesion#GO:0030155;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;serine protease#PC00203;protease#PC00190 HUMAN|HGNC=24450|UniProtKB=Q8WXF8 Q8WXF8 DEDD2 PTHR15205:SF1 DEATH EFFECTOR DOMAIN-CONTAINING PROTEIN DNA-BINDING DEATH EFFECTOR DOMAIN-CONTAINING PROTEIN 2 programmed cell death#GO:0012501;regulation of biological process#GO:0050789;cell death#GO:0008219;cellular response to stimulus#GO:0051716;apoptotic process#GO:0006915;extrinsic apoptotic signaling pathway#GO:0097191;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;cell communication#GO:0007154;signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;cell surface receptor signaling pathway#GO:0007166;extrinsic apoptotic signaling pathway via death domain receptors#GO:0008625;apoptotic signaling pathway#GO:0097190 organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228 HUMAN|HGNC=25691|UniProtKB=Q8N9V6 Q8N9V6 ANKRD53 PTHR24160:SF1 ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 53 ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 53 positive regulation of cellular component biogenesis#GO:0044089;regulation of cell cycle process#GO:0010564;regulation of microtubule cytoskeleton organization#GO:0070507;chromosome localization#GO:0050000;organelle organization#GO:0006996;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;metaphase chromosome alignment#GO:0051310;chromosome segregation#GO:0007059;regulation of cellular component organization#GO:0051128;regulation of cell cycle#GO:0051726;regulation of cellular component biogenesis#GO:0044087;sister chromatid segregation#GO:0000819;regulation of protein-containing complex assembly#GO:0043254;nuclear chromosome segregation#GO:0098813;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;mitotic nuclear division#GO:0140014;regulation of organelle organization#GO:0033043;cell cycle process#GO:0022402;regulation of mitotic spindle organization#GO:0060236;positive regulation of organelle organization#GO:0010638;regulation of microtubule polymerization#GO:0031113;nuclear division#GO:0000280;regulation of cytokinesis#GO:0032465;positive regulation of cellular component organization#GO:0051130;positive regulation of protein polymerization#GO:0032273;biological regulation#GO:0065007;mitotic sister chromatid segregation#GO:0000070;positive regulation of cellular process#GO:0048522;regulation of mitotic cytokinesis#GO:1902412;mitotic cell cycle process#GO:1903047;regulation of microtubule polymerization or depolymerization#GO:0031110;chromosome organization#GO:0051276;regulation of protein polymerization#GO:0032271;mitotic cell cycle#GO:0000278;regulation of cytoskeleton organization#GO:0051493;regulation of spindle organization#GO:0090224;regulation of cellular process#GO:0050794;cell cycle#GO:0007049;regulation of supramolecular fiber organization#GO:1902903;mitotic metaphase chromosome alignment#GO:0007080;localization#GO:0051179;organelle fission#GO:0048285;organelle localization#GO:0051640;regulation of cell division#GO:0051302;regulation of microtubule-based process#GO:0032886 cytoskeleton#GO:0005856;spindle#GO:0005819;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;spindle pole#GO:0000922;microtubule cytoskeleton#GO:0015630;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232 HUMAN|HGNC=28431|UniProtKB=Q8N2G4 Q8N2G4 LYPD1 PTHR10036:SF7 CD59 GLYCOPROTEIN LY6_PLAUR DOMAIN-CONTAINING PROTEIN 1 acetylcholine receptor inhibitor activity#GO:0030550;acetylcholine receptor regulator activity#GO:0030548;signaling receptor regulator activity#GO:0030545;signaling receptor inhibitor activity#GO:0030547;molecular function inhibitor activity#GO:0140678;molecular function regulator activity#GO:0098772;neurotransmitter receptor regulator activity#GO:0099602 cellular response to nitrogen compound#GO:1901699;acetylcholine receptor signaling pathway#GO:0095500;response to chemical#GO:0042221;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;synaptic signaling#GO:0099536;cellular process#GO:0009987;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cell communication#GO:0007154;response to nitrogen compound#GO:1901698;cellular response to chemical stimulus#GO:0070887;response to oxygen-containing compound#GO:1901700 HUMAN|HGNC=15198|UniProtKB=Q8NGK0 Q8NGK0 OR51G2 PTHR26450:SF133 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 51G2 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=1136|UniProtKB=Q7KYR7 Q7KYR7 BTN2A1 PTHR24100:SF79 BUTYROPHILIN BUTYROPHILIN SUBFAMILY 2 MEMBER A1 protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488 immune system process#GO:0002376;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;immune response-regulating signaling pathway#GO:0002764;immune response-activating signaling pathway#GO:0002757;cell surface receptor signaling pathway#GO:0007166;regulation of multicellular organismal process#GO:0051239;antigen receptor-mediated signaling pathway#GO:0050851;activation of immune response#GO:0002253;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;positive regulation of immune system process#GO:0002684;cell communication#GO:0007154;regulation of immune response#GO:0050776;immune response-activating cell surface receptor signaling pathway#GO:0002429;regulation of macromolecule metabolic process#GO:0060255;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;T cell receptor signaling pathway#GO:0050852;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;positive regulation of response to stimulus#GO:0048584;regulation of cytokine production#GO:0001817;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 membrane#GO:0016020;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=8982|UniProtKB=Q99570 Q99570 PIK3R4 PTHR17583:SF0 PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4 PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4 transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 establishment of protein localization to vacuole#GO:0072666;catabolic process#GO:0009056;protein targeting#GO:0006605;protein localization to organelle#GO:0033365;late endosome to vacuole transport#GO:0045324;protein localization to vacuole#GO:0072665;localization#GO:0051179;cellular localization#GO:0051641;protein transport#GO:0015031;process utilizing autophagic mechanism#GO:0061919;macromolecule localization#GO:0033036;protein targeting to vacuole#GO:0006623;establishment of protein localization#GO:0045184;autophagy#GO:0006914;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;macroautophagy#GO:0016236;metabolic process#GO:0008152;intracellular transport#GO:0046907;vacuolar transport#GO:0007034;intracellular protein transport#GO:0006886;transport#GO:0006810;establishment of protein localization to organelle#GO:0072594;pexophagy#GO:0000425;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;organelle membrane contact site#GO:0044232;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;endosome#GO:0005768;phosphatidylinositol 3-kinase complex, class III#GO:0035032;transferase complex, transferring phosphorus-containing groups#GO:0061695;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;late endosome#GO:0005770;endomembrane system#GO:0012505;membrane#GO:0016020;extrinsic component of membrane#GO:0019898;transferase complex#GO:1990234 kinase modulator#PC00140;protein-binding activity modulator#PC00095 HUMAN|HGNC=31805|UniProtKB=Q5JRK9 Q5JRK9 PAGE2B PTHR14047:SF34 P ANTIGEN FAMILY MEMBER 5-RELATED G ANTIGEN FAMILY E MEMBER 3-RELATED HUMAN|HGNC=33714|UniProtKB=A5D6W6 A5D6W6 FITM1 PTHR23129:SF3 ACYL-COENZYME A DIPHOSPHATASE FITM2 FAT STORAGE-INDUCING TRANSMEMBRANE PROTEIN 1 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787 cell differentiation#GO:0030154;homeostatic process#GO:0042592;membraneless organelle assembly#GO:0140694;lipid homeostasis#GO:0055088;fat cell differentiation#GO:0045444;cellular component organization#GO:0016043;lipid droplet organization#GO:0034389;organelle assembly#GO:0070925;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;lipid storage#GO:0019915;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;chemical homeostasis#GO:0048878;developmental process#GO:0032502 endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 phosphatase#PC00181;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=2943|UniProtKB=Q6ZR08 Q6ZR08 DNAH12 PTHR46532:SF11 MALE FERTILITY FACTOR KL5 DYNEIN AXONEMAL HEAVY CHAIN 12 HUMAN|HGNC=17885|UniProtKB=Q8NFT2 Q8NFT2 STEAP2 PTHR14239:SF6 DUDULIN-RELATED METALLOREDUCTASE STEAP2 ferric-chelate reductase activity#GO:0000293;catalytic activity#GO:0003824;oxidoreductase activity, acting on metal ions#GO:0016722;oxidoreductase activity#GO:0016491 transport#GO:0006810;transition metal ion transport#GO:0000041;monoatomic ion transport#GO:0006811;metal ion transport#GO:0030001;establishment of localization#GO:0051234;localization#GO:0051179;monoatomic cation transport#GO:0006812 vesicle#GO:0031982;cell periphery#GO:0071944;intracellular vesicle#GO:0097708;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410 reductase#PC00198 HUMAN|HGNC=13266|UniProtKB=Q9GZR7 Q9GZR7 DDX24 PTHR24031:SF91 RNA HELICASE ATP-DEPENDENT RNA HELICASE DDX24 metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;maturation of LSU-rRNA#GO:0000470;gene expression#GO:0010467;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;ribosomal large subunit biogenesis#GO:0042273;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613 nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231 RNA helicase#PC00032;RNA metabolism protein#PC00031 HUMAN|HGNC=37261|UniProtKB=Q6ZMT9 Q6ZMT9 DTHD1 PTHR28336:SF4 BA1-643 DEATH DOMAIN-CONTAINING PROTEIN 1 HUMAN|HGNC=6399|UniProtKB=O60684 O60684 KPNA6 PTHR23316:SF8 IMPORTIN ALPHA IMPORTIN SUBUNIT ALPHA-7 nucleocytoplasmic carrier activity#GO:0140142;molecular carrier activity#GO:0140104 intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;protein localization to nucleus#GO:0034504;macromolecule localization#GO:0033036;import into nucleus#GO:0051170;protein transport#GO:0015031;protein import into nucleus#GO:0006606;nuclear transport#GO:0051169;cellular localization#GO:0051641;localization#GO:0051179;NLS-bearing protein import into nucleus#GO:0006607;nucleocytoplasmic transport#GO:0006913;protein localization to organelle#GO:0033365 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 transporter#PC00227 HUMAN|HGNC=7669|UniProtKB=Q15596 Q15596 NCOA2 PTHR10684:SF2 NUCLEAR RECEPTOR COACTIVATOR NUCLEAR RECEPTOR COACTIVATOR 2 transcription regulator activity#GO:0140110;binding#GO:0005488;DNA-binding transcription factor binding#GO:0140297;RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629;protein binding#GO:0005515;transcription factor binding#GO:0008134;nuclear receptor binding#GO:0016922;transcription coregulator activity#GO:0003712;transcription coactivator activity#GO:0003713 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;cellular response to stimulus#GO:0051716;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of macromolecule metabolic process#GO:0010604;response to chemical#GO:0042221;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;response to hormone#GO:0009725;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;cellular response to chemical stimulus#GO:0070887;cellular response to hormone stimulus#GO:0032870;regulation of transcription by RNA polymerase II#GO:0006357;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 histone modifying enzyme#PC00261 HUMAN|HGNC=24320|UniProtKB=Q71RC2 Q71RC2 LARP4 PTHR22792:SF48 LUPUS LA PROTEIN-RELATED LA-RELATED PROTEIN 4 mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA 3'-UTR binding#GO:0003730 RNA metabolism protein#PC00031 HUMAN|HGNC=476|UniProtKB=P0DTE8 P0DTE8 AMY1C PTHR43447:SF50 ALPHA-AMYLASE ALPHA-AMYLASE 1A-RELATED cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 amylase#PC00048 HUMAN|HGNC=8854|UniProtKB=O00623 O00623 PEX12 PTHR12888:SF2 PEROXISOME ASSEMBLY PROTEIN 12 PEROXIN-12 PEROXISOME ASSEMBLY PROTEIN 12 enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme activator activity#GO:0008047 cellular process#GO:0009987;peroxisome organization#GO:0007031;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular component organization or biogenesis#GO:0071840 microbody#GO:0042579;membrane#GO:0016020;peroxisome#GO:0005777;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;peroxisomal membrane#GO:0005778;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane-bounded organelle#GO:0043227 chaperone#PC00072 HUMAN|HGNC=17933|UniProtKB=Q9H7Z6 Q9H7Z6 KAT8 PTHR10615:SF82 HISTONE ACETYLTRANSFERASE HISTONE ACETYLTRANSFERASE KAT8 N-acetyltransferase activity#GO:0008080;protein-lysine-acetyltransferase activity#GO:0061733;acetyltransferase activity#GO:0016407;acyltransferase activity#GO:0016746;histone acetyltransferase activity#GO:0004402;histone modifying activity#GO:0140993;protein N-acyltransferase activity#GO:0140186;catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity, acting on a protein#GO:0140096;protein N-acetyltransferase activity#GO:0034212 catalytic complex#GO:1902494;intracellular organelle#GO:0043229;protein acetyltransferase complex#GO:0031248;acetyltransferase complex#GO:1902493;intracellular anatomical structure#GO:0005622;NSL complex#GO:0044545;chromosome#GO:0005694;organelle#GO:0043226;cellular anatomical structure#GO:0110165;transferase complex#GO:1990234;histone acetyltransferase complex#GO:0000123;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;chromatin#GO:0000785;intracellular membraneless organelle#GO:0043232;NuA4 histone acetyltransferase complex#GO:0035267;protein-containing complex#GO:0032991;H4 histone acetyltransferase complex#GO:1902562 chromatin/chromatin-binding, or -regulatory protein#PC00077;histone modifying enzyme#PC00261 HUMAN|HGNC=7805|UniProtKB=P25208 P25208 NFYB PTHR11064:SF205 CCAAT-BINDING TRANSCRIPTION FACTOR-RELATED NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT BETA sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HUMAN|HGNC=18362|UniProtKB=Q9BZV3 Q9BZV3 IMPG2 PTHR12199:SF4 INTERPHOTORECEPTOR MATRIX PROTEOGLYCAN INTERPHOTORECEPTOR MATRIX PROTEOGLYCAN 2 organic acid binding#GO:0043177;ion binding#GO:0043167;glycosaminoglycan binding#GO:0005539;small molecule binding#GO:0036094;anion binding#GO:0043168;carboxylic acid binding#GO:0031406;binding#GO:0005488;heparin binding#GO:0008201;carbohydrate derivative binding#GO:0097367 extracellular matrix protein#PC00102 HUMAN|HGNC=23227|UniProtKB=Q8WVF5 Q8WVF5 KCTD4 PTHR14499:SF9 POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD4 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 scaffold/adaptor protein#PC00226 HUMAN|HGNC=20278|UniProtKB=Q8TB37 Q8TB37 NUBPL PTHR42961:SF4 IRON-SULFUR PROTEIN NUBPL IRON-SULFUR CLUSTER TRANSFER PROTEIN NUBPL iron-sulfur cluster binding#GO:0051536;binding#GO:0005488;small molecule binding#GO:0036094 cellular component assembly#GO:0022607;mitochondrial respiratory chain complex assembly#GO:0033108;mitochondrion organization#GO:0007005;iron-sulfur cluster assembly#GO:0016226;mitochondrial respiratory chain complex I assembly#GO:0032981;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;cellular component organization or biogenesis#GO:0071840;NADH dehydrogenase complex assembly#GO:0010257;protein-containing complex organization#GO:0043933 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=15196|UniProtKB=A6NGY5 A6NGY5 OR51F1 PTHR26450:SF46 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 51F1 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=11408|UniProtKB=Q13043 Q13043 STK4 PTHR48015:SF32 SERINE/THREONINE-PROTEIN KINASE TAO SERINE_THREONINE-PROTEIN KINASE 4 protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 negative regulation of response to stimulus#GO:0048585;negative regulation of Wnt signaling pathway#GO:0030178;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of cellular process#GO:0048522;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;negative regulation of signal transduction#GO:0009968;hippo signaling#GO:0035329;regulation of canonical Wnt signaling pathway#GO:0060828;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of apoptotic process#GO:0043065;regulation of apoptotic process#GO:0042981;regulation of MAPK cascade#GO:0043408;positive regulation of programmed cell death#GO:0043068;response to stimulus#GO:0050896;regulation of Wnt signaling pathway#GO:0030111;signaling#GO:0023052;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of cell communication#GO:0010648;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;negative regulation of canonical Wnt signaling pathway#GO:0090090;regulation of signaling#GO:0023051 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=20792|UniProtKB=Q9BS91 Q9BS91 SLC35A5 PTHR10231:SF90 NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER UDP-SUGAR TRANSPORTER PROTEIN SLC35A5 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;cellular process#GO:0009987;transport#GO:0006810 membrane-bounded organelle#GO:0043227;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;membrane#GO:0016020 transporter#PC00227 HUMAN|HGNC=25727|UniProtKB=Q8TAP6 Q8TAP6 CEP76 PTHR46436:SF1 CENTROSOMAL PROTEIN OF 76 KDA CENTROSOMAL PROTEIN OF 76 KDA regulation of cell cycle#GO:0051726;regulation of cell cycle process#GO:0010564;biological regulation#GO:0065007;regulation of cellular component biogenesis#GO:0044087;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of organelle assembly#GO:1902115;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;regulation of microtubule-based process#GO:0032886 organelle#GO:0043226;cellular anatomical structure#GO:0110165;centriole#GO:0005814;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 HUMAN|HGNC=10618|UniProtKB=P13500 P13500 CCL2 PTHR12015:SF98 SMALL INDUCIBLE CYTOKINE A C-C MOTIF CHEMOKINE 2 chemokine activity#GO:0008009;G protein-coupled receptor binding#GO:0001664;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;cytokine activity#GO:0005125;cytokine receptor binding#GO:0005126;binding#GO:0005488;signaling receptor binding#GO:0005102;molecular function activator activity#GO:0140677;protein binding#GO:0005515;chemokine receptor binding#GO:0042379 granulocyte chemotaxis#GO:0071621;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052;positive regulation of cell motility#GO:2000147;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;response to peptide#GO:1901652;cellular response to chemical stimulus#GO:0070887;immune system process#GO:0002376;G protein-coupled receptor signaling pathway#GO:0007186;taxis#GO:0042330;response to chemical#GO:0042221;response to cytokine#GO:0034097;defense response to other organism#GO:0098542;granulocyte migration#GO:0097530;response to chemokine#GO:1990868;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;defense response to symbiont#GO:0140546;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;humoral immune response#GO:0006959;antimicrobial humoral response#GO:0019730;cell surface receptor signaling pathway#GO:0007166;regulation of cellular process#GO:0050794;cell motility#GO:0048870;response to external biotic stimulus#GO:0043207;cellular response to chemokine#GO:1990869;locomotion#GO:0040011;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;regulation of cell motility#GO:2000145;chemokine-mediated signaling pathway#GO:0070098;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;cell chemotaxis#GO:0060326;cytokine-mediated signaling pathway#GO:0019221;inflammatory response#GO:0006954;chemotaxis#GO:0006935;cell migration#GO:0016477;biological regulation#GO:0065007;response to other organism#GO:0051707;regulation of locomotion#GO:0040012;immune response#GO:0006955;positive regulation of cellular process#GO:0048522;positive regulation of cell migration#GO:0030335;positive regulation of locomotion#GO:0040017;response to external stimulus#GO:0009605;myeloid leukocyte migration#GO:0097529;defense response#GO:0006952;leukocyte chemotaxis#GO:0030595;leukocyte migration#GO:0050900;regulation of cell migration#GO:0030334 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 cytokine#PC00083 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CHK#P00856 HUMAN|HGNC=4412|UniProtKB=O14610 O14610 GNGT2 PTHR13809:SF28 GUANINE NUCLEOTIDE-BINDING PROTEIN GAMMA SUBUNIT GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)_G(S)_G(O) SUBUNIT GAMMA-T2 hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;molecular function regulator activity#GO:0098772;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924;hydrolase activity#GO:0016787 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;membrane#GO:0016020;cytoplasmic side of plasma membrane#GO:0009898;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;cytoplasmic side of membrane#GO:0098562;extrinsic component of cytoplasmic side of plasma membrane#GO:0031234;extrinsic component of membrane#GO:0019898;side of membrane#GO:0098552;extrinsic component of plasma membrane#GO:0019897 heterotrimeric G-protein#PC00117 5HT2 type receptor mediated signaling pathway#P04374>G-protein#P04416;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Ggamma#P00751;Thyrotropin-releasing hormone receptor signaling pathway#P04394>G-Protein#P04584;Enkephalin release#P05913>G-Protein (s)#P05977;Angiotensin II-stimulated signaling through G proteins and beta-arrestin#P05911>Ggamma#P05929;Enkephalin release#P05913>G-Protein (i)#P05974;Opioid proopiomelanocortin pathway#P05917>G-protein#P06012;5HT4 type receptor mediated signaling pathway#P04376>G-protein#P04430;Metabotropic glutamate receptor group III pathway#P00039>G-Protein#P01045;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>G-Protein#P01073;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>G-Protein#P01085;Oxytocin receptor mediated signaling pathway#P04391>G-Protein#P04534;Cortocotropin releasing factor receptor signaling pathway#P04380>G-Protein#P04458;Metabotropic glutamate receptor group II pathway#P00040>G-protein#P01047;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Ggamma#P00726;Beta3 adrenergic receptor signaling pathway#P04379>G-Protein#P04448;Beta1 adrenergic receptor signaling pathway#P04377>G-Protein#P04436;Opioid prodynorphin pathway#P05916>G-protein#P06002;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GIRK#P00743;Endogenous cannabinoid signaling#P05730>Ggamma#P05744;Beta2 adrenergic receptor signaling pathway#P04378>G-Protein#P04443;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Ggamma#P00721;Histamine H2 receptor mediated signaling pathway#P04386>G-Protein#P04490;PI3 kinase pathway#P00048>Gbetagamma#P01188;5HT1 type receptor mediated signaling pathway#P04373>G-protein#P04408;GABA-B receptor II signaling#P05731>Ggamma#P05754;Opioid proenkephalin pathway#P05915>G-protein#P05994;Histamine H1 receptor mediated signaling pathway#P04385>G-Protein#P04488 HUMAN|HGNC=237|UniProtKB=O43306 O43306 ADCY6 PTHR45627:SF11 ADENYLATE CYCLASE TYPE 1 ADENYLATE CYCLASE TYPE 6 lyase activity#GO:0016829;adenylate cyclase activity#GO:0004016;catalytic activity#GO:0003824;phosphorus-oxygen lyase activity#GO:0016849;cyclase activity#GO:0009975 ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;carbohydrate derivative metabolic process#GO:1901135;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;cyclic nucleotide metabolic process#GO:0009187;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;nucleoside phosphate biosynthetic process#GO:1901293;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;nucleoside phosphate metabolic process#GO:0006753;cell communication#GO:0007154;organophosphate biosynthetic process#GO:0090407;ribose phosphate biosynthetic process#GO:0046390;signal transduction#GO:0007165;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;metabolic process#GO:0008152;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing compound biosynthetic process#GO:0034654;cyclic purine nucleotide metabolic process#GO:0052652;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;phosphorus metabolic process#GO:0006793;regulation of biological process#GO:0050789;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;response to stimulus#GO:0050896;small molecule metabolic process#GO:0044281;signaling#GO:0023052;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;G protein-coupled receptor signaling pathway#GO:0007186;ribonucleotide metabolic process#GO:0009259;cyclic nucleotide biosynthetic process#GO:0009190;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;nucleotide biosynthetic process#GO:0009165 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 adenylate cyclase#PC00043 GABA-B receptor II signaling#P05731>AC#P05760;Endothelin signaling pathway#P00019>Adenylate cyclase#P00569;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>cAMP cyclase#P00719;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>AC#P00841 HUMAN|HGNC=30207|UniProtKB=Q52LW3 Q52LW3 ARHGAP29 PTHR15228:SF7 SPERMATHECAL PHYSIOLOGY VARIANT RHO GTPASE-ACTIVATING PROTEIN 29 GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme activator activity#GO:0008047 negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of small GTPase mediated signal transduction#GO:0051056;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of response to stimulus#GO:0048585 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protein-binding activity modulator#PC00095;G-protein modulator#PC00022;GTPase-activating protein#PC00257 HUMAN|HGNC=20293|UniProtKB=Q7L211 Q7L211 ABHD13 PTHR12277:SF207 ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN PROTEIN ABHD13 catalytic activity, acting on a protein#GO:0140096;palmitoyl hydrolase activity#GO:0098599;hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;thiolester hydrolase activity#GO:0016790;catalytic activity#GO:0003824 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 serine protease#PC00203 HUMAN|HGNC=29331|UniProtKB=Q9HCE0 Q9HCE0 EPG5 PTHR31139:SF4 ECTOPIC P GRANULES PROTEIN 5 HOMOLOG ECTOPIC P GRANULES PROTEIN 5 HOMOLOG lytic vacuole#GO:0000323;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vacuole#GO:0005773;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;lysosome#GO:0005764 HUMAN|HGNC=33760|UniProtKB=Q6PEX3 Q6PEX3 KRTAP26-1 PTHR23262:SF245 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 26-1 structural protein#PC00211 HUMAN|HGNC=20356|UniProtKB=Q9BXV9 Q9BXV9 GON7 PTHR37363:SF1 EKC/KEOPS COMPLEX SUBUNIT GON7 EKC_KEOPS COMPLEX SUBUNIT GON7 transferase complex#GO:1990234;catalytic complex#GO:1902494;protein-containing complex#GO:0032991 HUMAN|HGNC=16140|UniProtKB=Q8TBE9 Q8TBE9 NANP PTHR46470:SF3 N-ACYLNEURAMINATE-9-PHOSPHATASE N-ACYLNEURAMINATE-9-PHOSPHATASE hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787 metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;small molecule biosynthetic process#GO:0044283;carbohydrate derivative biosynthetic process#GO:1901137;carboxylic acid metabolic process#GO:0019752;cellular process#GO:0009987;carboxylic acid biosynthetic process#GO:0046394;carbohydrate derivative metabolic process#GO:1901135;amino sugar metabolic process#GO:0006040;small molecule metabolic process#GO:0044281;biosynthetic process#GO:0009058 metabolite interconversion enzyme#PC00262;phosphatase#PC00181 HUMAN|HGNC=31110|UniProtKB=Q4LDR2 Q4LDR2 CTXN3 PTHR16736:SF1 CORTEXIN-1-RELATED CORTEXIN-3 HUMAN|HGNC=26634|UniProtKB=Q8N239 Q8N239 KLHL34 PTHR45632:SF8 LD33804P KELCH-LIKE PROTEIN 34 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;enzyme-substrate adaptor activity#GO:0140767;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632 intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;Cul3-RING ubiquitin ligase complex#GO:0031463;catalytic complex#GO:1902494;transferase complex#GO:1990234 scaffold/adaptor protein#PC00226 HUMAN|HGNC=7102|UniProtKB=Q9UNW1 Q9UNW1 MINPP1 PTHR20963:SF57 MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE 1 hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788 intracellular organelle lumen#GO:0070013;extracellular region#GO:0005576;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;endoplasmic reticulum lumen#GO:0005788;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 phosphatase#PC00181;hydrolase#PC00121 HUMAN|HGNC=8687|UniProtKB=Q9Y5E7 Q9Y5E7 PCDHB2 PTHR24028:SF281 CADHERIN-87A PROTOCADHERIN BETA-2 cellular process#GO:0009987;cell adhesion#GO:0007155 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HUMAN|HGNC=25873|UniProtKB=Q9H7X2 Q9H7X2 C1orf115 PTHR14680:SF1 SI:DKEY-126G1.9-RELATED REQUIRED FOR DRUG-INDUCED DEATH PROTEIN 1 HUMAN|HGNC=3340|UniProtKB=Q04741 Q04741 EMX1 PTHR24339:SF26 HOMEOBOX PROTEIN EMX-RELATED HOMEOBOX PROTEIN EMX1 nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;animal organ development#GO:0048513;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;multicellular organism development#GO:0007275;developmental process#GO:0032502;neuron differentiation#GO:0030182;nervous system development#GO:0007399;head development#GO:0060322;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;brain development#GO:0007420;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;central nervous system development#GO:0007417;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 homeodomain transcription factor#PC00119 HUMAN|HGNC=28465|UniProtKB=Q8WV48 Q8WV48 CCDC107 PTHR37345:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 107 COILED-COIL DOMAIN-CONTAINING PROTEIN 107 HUMAN|HGNC=26371|UniProtKB=Q8N7E2 Q8N7E2 CBLL2 PTHR13480:SF1 E3 UBIQUITIN-PROTEIN LIGASE HAKAI-RELATED E3 UBIQUITIN-PROTEIN LIGASE CBLL2 aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746 protein ubiquitination#GO:0016567;biological regulation#GO:0065007;post-translational protein modification#GO:0043687;regulation of cell adhesion#GO:0030155;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;protein modification by small protein conjugation#GO:0032446;cellular process#GO:0009987;protein modification process#GO:0036211;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=11640|UniProtKB=Q9HCS4 Q9HCS4 TCF7L1 PTHR10373:SF25 TRANSCRIPTION FACTOR 7 FAMILY MEMBER TRANSCRIPTION FACTOR 7-LIKE 1 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 cell surface receptor signaling pathway#GO:0007166;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of DNA-templated transcription#GO:0006355;canonical Wnt signaling pathway#GO:0060070;cell communication#GO:0007154;regulation of RNA metabolic process#GO:0051252;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;Wnt signaling pathway#GO:0016055;signaling#GO:0023052 membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;RNA polymerase II transcription regulator complex#GO:0090575;chromosome#GO:0005694;chromatin#GO:0000785;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 Wnt signaling pathway#P00057>TCF#P01437;Wnt signaling pathway#P00057>Wnt Target Genes#G01558;Alzheimer disease-presenilin pathway#P00004>TCF/LEF#P00143;Gonadotropin-releasing hormone receptor pathway#P06664>TCF#P06701;Cadherin signaling pathway#P00012>TCF/LEF#P00465 HUMAN|HGNC=19321|UniProtKB=Q9C056 Q9C056 NKX6-2 PTHR24340:SF21 HOMEOBOX PROTEIN NKX HOMEOBOX PROTEIN NKX-6.2 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 developmental process#GO:0032502;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=18006|UniProtKB=Q9Y2I1 Q9Y2I1 NISCH PTHR15454:SF35 NISCHARIN RELATED NISCHARIN cell communication#GO:0007154;Rac protein signal transduction#GO:0016601;intracellular signal transduction#GO:0035556;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;signaling#GO:0023052;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789 scaffold/adaptor protein#PC00226 HUMAN|HGNC=19022|UniProtKB=O43301 O43301 HSPA12A PTHR14187:SF46 ALPHA KINASE/ELONGATION FACTOR 2 KINASE HEAT SHOCK 70 KDA PROTEIN 12A HUMAN|HGNC=12544|UniProtKB=P36537 P36537 UGT2B10 PTHR48043:SF86 EG:EG0003.4 PROTEIN-RELATED UDP-GLUCURONOSYLTRANSFERASE 2B10-RELATED hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740;glucuronosyltransferase activity#GO:0015020;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757 biological regulation#GO:0065007;steroid metabolic process#GO:0008202;hormone metabolic process#GO:0042445;cellular process#GO:0009987;regulation of hormone levels#GO:0010817;primary metabolic process#GO:0044238;regulation of biological quality#GO:0065008;estrogen metabolic process#GO:0008210;lipid metabolic process#GO:0006629;metabolic process#GO:0008152 HUMAN|HGNC=4584|UniProtKB=Q05586 Q05586 GRIN1 PTHR18966:SF377 IONOTROPIC GLUTAMATE RECEPTOR GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1 voltage-gated monoatomic ion channel activity#GO:0005244;transmembrane signaling receptor activity#GO:0004888;gated channel activity#GO:0022836;voltage-gated channel activity#GO:0022832;neurotransmitter receptor activity#GO:0030594;amino acid transmembrane transporter activity#GO:0015171;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion channel activity#GO:0005216;signaling receptor activity#GO:0038023;carboxylic acid transmembrane transporter activity#GO:0046943;ligand-gated monoatomic ion channel activity#GO:0015276;molecular transducer activity#GO:0060089;channel activity#GO:0015267;glutamate receptor activity#GO:0008066;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;dicarboxylic acid transmembrane transporter activity#GO:0005310 biological regulation#GO:0065007;cell-cell signaling#GO:0007267;synaptic signaling#GO:0099536;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of membrane potential#GO:0042391;cell surface receptor signaling pathway#GO:0007166;anterograde trans-synaptic signaling#GO:0098916;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;glutamate receptor signaling pathway#GO:0007215;regulation of biological quality#GO:0065008;trans-synaptic signaling#GO:0099537 plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165;synapse#GO:0045202;transmembrane transporter complex#GO:1902495;neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;signaling receptor complex#GO:0043235;cell junction#GO:0030054;transporter complex#GO:1990351 transmembrane signal receptor#PC00197 Ionotropic glutamate receptor pathway#P00037>NMDA#P01024;Metabotropic glutamate receptor group I pathway#P00041>NMDA#P01060;Huntington disease#P00029>NMDA receptor#P00778;Metabotropic glutamate receptor group III pathway#P00039>NMDA#P01039;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>NMDA#P01071;Ionotropic glutamate receptor pathway#P00037>NR1#P01010 HUMAN|HGNC=2098|UniProtKB=Q9Y471 Q9Y471 CMAHP PTHR46522:SF1 CYTIDINE MONOPHOSPHATE-N-ACETYLNEURAMINIC ACID HYDROXYLASE INACTIVE CYTIDINE MONOPHOSPHATE-N-ACETYLNEURAMINIC ACID HYDROXYLASE catalytic activity#GO:0003824;monooxygenase activity#GO:0004497;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;oxidoreductase activity#GO:0016491 cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;organophosphate metabolic process#GO:0019637;nucleoside phosphate metabolic process#GO:0006753;nucleotide-sugar metabolic process#GO:0009225;nucleobase-containing compound metabolic process#GO:0006139;small molecule metabolic process#GO:0044281;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 oxidoreductase#PC00176;hydroxylase#PC00122 HUMAN|HGNC=26724|UniProtKB=Q68DC2 Q68DC2 ANKS6 PTHR10627:SF70 SCP160 ANKYRIN REPEAT AND SAM DOMAIN-CONTAINING PROTEIN 6 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HUMAN|HGNC=1965|UniProtKB=Q07001 Q07001 CHRND PTHR18945:SF61 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR SUBUNIT DELTA signaling receptor activity#GO:0038023;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;transporter activity#GO:0005215;neurotransmitter receptor activity#GO:0030594;monoatomic cation transmembrane transporter activity#GO:0008324;gated channel activity#GO:0022836;postsynaptic neurotransmitter receptor activity#GO:0098960;monoatomic cation channel activity#GO:0005261;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;channel activity#GO:0015267;molecular transducer activity#GO:0060089;ligand-gated monoatomic ion channel activity#GO:0015276 transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;cellular response to chemical stimulus#GO:0070887;response to oxygen-containing compound#GO:1901700;nervous system process#GO:0050877;response to stimulus#GO:0050896;skeletal muscle contraction#GO:0003009;signaling#GO:0023052;muscle system process#GO:0003012;regulation of biological process#GO:0050789;regulation of membrane potential#GO:0042391;calcium ion transport#GO:0006816;response to chemical#GO:0042221;synaptic signaling#GO:0099536;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;cellular process#GO:0009987;monoatomic cation transport#GO:0006812;localization#GO:0051179;cell communication#GO:0007154;response to nitrogen compound#GO:1901698;trans-synaptic signaling#GO:0099537;neuromuscular process#GO:0050905;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;metal ion transport#GO:0030001;striated muscle contraction#GO:0006941;membrane depolarization#GO:0051899;chemical synaptic transmission#GO:0007268;cellular response to stimulus#GO:0051716;establishment of localization#GO:0051234;system process#GO:0003008;muscle contraction#GO:0006936;transport#GO:0006810;synaptic transmission, cholinergic#GO:0007271;acetylcholine receptor signaling pathway#GO:0095500;multicellular organismal process#GO:0032501;cellular response to nitrogen compound#GO:1901699;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;monoatomic ion transmembrane transport#GO:0034220 postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;transmembrane transporter complex#GO:1902495;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;postsynapse#GO:0098794;organelle#GO:0043226;cellular anatomical structure#GO:0110165;synapse#GO:0045202;signaling receptor complex#GO:0043235;synaptic membrane#GO:0097060;cell junction#GO:0030054;transporter complex#GO:1990351;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991 ligand-gated ion channel#PC00141 Nicotinic acetylcholine receptor signaling pathway#P00044>delta#P01092;Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086 HUMAN|HGNC=7851|UniProtKB=Q13232 Q13232 NME3 PTHR11349:SF54 NUCLEOSIDE DIPHOSPHATE KINASE NUCLEOSIDE DIPHOSPHATE KINASE C transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleobase-containing compound kinase activity#GO:0019205;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;nucleoside diphosphate kinase activity#GO:0004550;phosphotransferase activity, phosphate group as acceptor#GO:0016776 cellular process#GO:0009987;nucleoside triphosphate biosynthetic process#GO:0009142;phosphorus metabolic process#GO:0006793;metabolic process#GO:0008152;nucleoside triphosphate metabolic process#GO:0009141;biosynthetic process#GO:0009058 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 transferase#PC00220;kinase#PC00137 De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>dTDP kinase#P02919;De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>dCDP kinase#P02914;De novo purine biosynthesis#P02738>dGDP kinase#P02889;De novo pyrimidine ribonucleotides biosythesis#P02740>CDP kinase#P02929;De novo purine biosynthesis#P02738>dADP kinase#P02907;De novo pyrimidine ribonucleotides biosythesis#P02740>UDP kinase#P02923;Salvage pyrimidine ribonucleotides#P02775>CDP kinase#P03156;De novo purine biosynthesis#P02738>GDP kinase#P02891;De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>dUDP kinase#P02912 HUMAN|HGNC=15162|UniProtKB=Q8NH83 Q8NH83 OR4A5 PTHR48002:SF161 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 4A5-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=3170|UniProtKB=O95977 O95977 S1PR4 PTHR22750:SF13 G-PROTEIN COUPLED RECEPTOR SPHINGOSINE 1-PHOSPHATE RECEPTOR 4 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089 cell communication#GO:0007154;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789 plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021 HUMAN|HGNC=29996|UniProtKB=Q8TAE8 Q8TAE8 GADD45GIP1 PTHR31761:SF1 GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEINS-INTERACTING PROTEIN 1 GADD45GIP1 LARGE RIBOSOMAL SUBUNIT PROTEIN ML64 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=31665|UniProtKB=Q6P461 Q6P461 ACSM6 PTHR43605:SF1 ACYL-COENZYME A SYNTHETASE ACYL-COENZYME A SYNTHETASE ACSM6, MITOCHONDRIAL ligase activity#GO:0016874;ATP-dependent activity#GO:0140657;acyltransferase activity#GO:0016746;ligase activity, forming carbon-sulfur bonds#GO:0016877;catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;monocarboxylic acid biosynthetic process#GO:0072330;nucleobase-containing small molecule metabolic process#GO:0055086;acyl-CoA metabolic process#GO:0006637;organophosphate metabolic process#GO:0019637;sulfur compound metabolic process#GO:0006790;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;nucleobase-containing compound metabolic process#GO:0006139;fatty acid biosynthetic process#GO:0006633;biosynthetic process#GO:0009058;oxoacid metabolic process#GO:0043436;monocarboxylic acid metabolic process#GO:0032787;phosphorus metabolic process#GO:0006793;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;purine-containing compound metabolic process#GO:0072521;carboxylic acid biosynthetic process#GO:0046394;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;ligase#PC00142 HUMAN|HGNC=1939|UniProtKB=O00533 O00533 CHL1 PTHR12231:SF257 CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN NEURAL CELL ADHESION MOLECULE L1-LIKE PROTEIN immunoglobulin superfamily cell adhesion molecule#PC00125;cell adhesion molecule#PC00069 HUMAN|HGNC=3770|UniProtKB=Q99518 Q99518 FMO2 PTHR23023:SF84 DIMETHYLANILINE MONOOXYGENASE FLAVIN-CONTAINING MONOOXYGENASE 2 oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;monooxygenase activity#GO:0004497;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen#GO:0016709;catalytic activity#GO:0003824 xenobiotic metabolic process#GO:0006805;cellular response to xenobiotic stimulus#GO:0071466;response to chemical#GO:0042221;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to xenobiotic stimulus#GO:0009410;cellular response to chemical stimulus#GO:0070887;metabolic process#GO:0008152 oxidoreductase#PC00176;oxygenase#PC00177 HUMAN|HGNC=708|UniProtKB=O15511 O15511 ARPC5 PTHR12644:SF1 ARP2/3 COMPLEX 16 KD SUBUNIT P16-ARC ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 5 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 actin filament-based process#GO:0030029;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cellular component organization or biogenesis#GO:0071840;Arp2/3 complex-mediated actin nucleation#GO:0034314;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;cell motility#GO:0048870;actin nucleation#GO:0045010;cell migration#GO:0016477 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;Arp2/3 protein complex#GO:0005885;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;actin cytoskeleton#GO:0015629;cortical cytoskeleton#GO:0030863;cell cortex#GO:0005938;cell periphery#GO:0071944 actin or actin-binding cytoskeletal protein#PC00041 Huntington disease#P00029>Arp2/3 complex#P00811;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Arp2/3#P00876;Cytoskeletal regulation by Rho GTPase#P00016>ARP2/3#P00511;Integrin signalling pathway#P00034>Arp2/3#P00912 HUMAN|HGNC=11694|UniProtKB=P51808 P51808 DYNLT3 PTHR21255:SF20 T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN DYNEIN LIGHT CHAIN TCTEX-TYPE 3 protein binding#GO:0005515;binding#GO:0005488 cellular process#GO:0009987;microtubule-based movement#GO:0007018;microtubule-based process#GO:0007017 cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;microtubule associated complex#GO:0005875;organelle#GO:0043226;dynein complex#GO:0030286;cytoplasmic dynein complex#GO:0005868;microtubule cytoskeleton#GO:0015630;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;cytoskeleton#GO:0005856 microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=12592|UniProtKB=P10746 P10746 UROS PTHR12390:SF0 UROPORPHYRINOGEN III SYNTHASE UROPORPHYRINOGEN-III SYNTHASE hydro-lyase activity#GO:0016836;carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;catalytic activity#GO:0003824 tetrapyrrole metabolic process#GO:0033013;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;small molecule biosynthetic process#GO:0044283;porphyrin-containing compound metabolic process#GO:0006778;porphyrin-containing compound biosynthetic process#GO:0006779;carboxylic acid metabolic process#GO:0019752;carboxylic acid biosynthetic process#GO:0046394;cellular process#GO:0009987;tetrapyrrole biosynthetic process#GO:0033014;small molecule metabolic process#GO:0044281;biosynthetic process#GO:0009058 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 Heme biosynthesis#P02746>Uroporphyrinogen-III synthase#P02974 HUMAN|HGNC=30162|UniProtKB=Q2M3D2 Q2M3D2 EXOC3L2 PTHR21292:SF7 EXOCYST COMPLEX COMPONENT SEC6-RELATED EXOCYST COMPLEX COMPONENT 3-LIKE PROTEIN 2 protein binding#GO:0005515;SNARE binding#GO:0000149;binding#GO:0005488 secretion by cell#GO:0032940;exocytosis#GO:0006887;secretion#GO:0046903;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810;export from cell#GO:0140352;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987 cytoplasm#GO:0005737;exocyst#GO:0000145;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cell cortex#GO:0005938;cell periphery#GO:0071944;vesicle tethering complex#GO:0099023;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HUMAN|HGNC=21695|UniProtKB=Q9Y6U3 Q9Y6U3 SCIN PTHR11977:SF78 VILLIN SCINDERIN phosphatidylinositol phosphate binding#GO:1901981;cytoskeletal protein binding#GO:0008092;phospholipid binding#GO:0005543;lipid binding#GO:0008289;protein-containing complex binding#GO:0044877;protein binding#GO:0005515;phosphatidylinositol bisphosphate binding#GO:1902936;actin binding#GO:0003779;actin filament binding#GO:0051015;phosphatidylinositol-4,5-bisphosphate binding#GO:0005546;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;anion binding#GO:0043168 actin filament-based process#GO:0030029;actin filament capping#GO:0051693;negative regulation of protein polymerization#GO:0032272;anatomical structure development#GO:0048856;negative regulation of protein-containing complex disassembly#GO:0043242;negative regulation of cytoskeleton organization#GO:0051494;supramolecular fiber organization#GO:0097435;system development#GO:0048731;negative regulation of protein-containing complex assembly#GO:0031333;negative regulation of cellular component organization#GO:0051129;negative regulation of organelle organization#GO:0010639;regulation of supramolecular fiber organization#GO:1902903;regulation of cellular process#GO:0050794;actin cytoskeleton organization#GO:0030036;regulation of protein polymerization#GO:0032271;negative regulation of supramolecular fiber organization#GO:1902904;regulation of cytoskeleton organization#GO:0051493;regulation of actin filament depolymerization#GO:0030834;negative regulation of cellular process#GO:0048523;regulation of actin filament-based process#GO:0032970;developmental process#GO:0032502;regulation of protein depolymerization#GO:1901879;actin filament organization#GO:0007015;regulation of actin filament organization#GO:0110053;actin polymerization or depolymerization#GO:0008154;multicellular organismal process#GO:0032501;regulation of actin filament polymerization#GO:0030833;negative regulation of protein depolymerization#GO:1901880;regulation of actin polymerization or depolymerization#GO:0008064;biological regulation#GO:0065007;animal gross anatomical part developmental process#GO:0160108;regulation of actin filament length#GO:0030832;negative regulation of actin filament depolymerization#GO:0030835;regulation of biological quality#GO:0065008;regulation of protein-containing complex assembly#GO:0043254;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of cellular component size#GO:0032535;cell projection organization#GO:0030030;central nervous system development#GO:0007417;regulation of cellular component organization#GO:0051128;regulation of cellular component biogenesis#GO:0044087;negative regulation of actin filament polymerization#GO:0030837;regulation of anatomical structure size#GO:0090066;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;organelle organization#GO:0006996;regulation of protein-containing complex disassembly#GO:0043244;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component assembly#GO:0022607;nervous system development#GO:0007399;regulation of actin cytoskeleton organization#GO:0032956;cytoskeleton organization#GO:0007010 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;actin cytoskeleton#GO:0015629 actin or actin-binding cytoskeletal protein#PC00041;non-motor actin binding protein#PC00165 FAS signaling pathway#P00020>Gelsolin#P00611 HUMAN|HGNC=29013|UniProtKB=Q2KHT3 Q2KHT3 CLEC16A PTHR21481:SF0 PROTEIN CLEC16A PROTEIN CLEC16A biological regulation#GO:0065007;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;regulation of protein-containing complex disassembly#GO:0043244;regulation of metabolic process#GO:0019222;endosomal transport#GO:0016197;regulation of macroautophagy#GO:0016241;regulation of catabolic process#GO:0009894;establishment of localization#GO:0051234;vacuolar transport#GO:0007034;regulation of autophagosome maturation#GO:1901096;transport#GO:0006810;intracellular transport#GO:0046907;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;regulation of autophagy#GO:0010506;localization#GO:0051179;cellular localization#GO:0051641 intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;late endosome#GO:0005770;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=30077|UniProtKB=Q00765 Q00765 REEP5 PTHR12300:SF93 HVA22-LIKE PROTEINS RECEPTOR EXPRESSION-ENHANCING PROTEIN 5 membrane traffic protein#PC00150 HUMAN|HGNC=27735|UniProtKB=Q8N4F7 Q8N4F7 RNF175 PTHR13407:SF2 RNF121 PROTEIN RING FINGER PROTEIN 175 transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842 cellular process#GO:0009987;response to stress#GO:0006950;proteasomal protein catabolic process#GO:0010498;response to chemical#GO:0042221;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;catabolic process#GO:0009056;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;response to endoplasmic reticulum stress#GO:0034976;ERAD pathway#GO:0036503;protein metabolic process#GO:0019538 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;cytoplasm#GO:0005737;endomembrane system#GO:0012505;membrane#GO:0016020 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=7622|UniProtKB=Q01538 Q01538 MYT1 PTHR10816:SF10 MYELIN TRANSCRIPTION FACTOR 1-RELATED MYELIN TRANSCRIPTION FACTOR 1 DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=13565|UniProtKB=Q9BQ16 Q9BQ16 SPOCK3 PTHR13866:SF21 SPARC OSTEONECTIN TESTICAN-3 molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866;enzyme inhibitor activity#GO:0004857;cation binding#GO:0043169;molecular function inhibitor activity#GO:0140678;metal ion binding#GO:0046872;enzyme regulator activity#GO:0030234;calcium ion binding#GO:0005509;peptidase regulator activity#GO:0061134;peptidase inhibitor activity#GO:0030414;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;endopeptidase regulator activity#GO:0061135 regulation of biological process#GO:0050789;regulation of cell adhesion#GO:0030155;regulation of cellular process#GO:0050794;regulation of cell-substrate adhesion#GO:0010810;biological regulation#GO:0065007 extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical structure#GO:0110165 extracellular matrix glycoprotein#PC00100;extracellular matrix protein#PC00102 HUMAN|HGNC=6335|UniProtKB=Q14952 Q14952 KIR2DS3 PTHR11738:SF195 MHC CLASS I NK CELL RECEPTOR KILLER CELL IMMUNOGLOBULIN-LIKE RECEPTOR 2DS3-RELATED signaling receptor activity#GO:0038023;immune receptor activity#GO:0140375;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 response to stimulus#GO:0050896;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;immune response-regulating signaling pathway#GO:0002764;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;regulation of immune response#GO:0050776;cell surface receptor signaling pathway#GO:0007166;regulation of response to stimulus#GO:0048583 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=18539|UniProtKB=P61266 P61266 STX1B PTHR19957:SF334 SYNTAXIN SYNTAXIN-1B SNAP receptor activity#GO:0005484;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 macromolecule localization#GO:0033036;organelle organization#GO:0006996;membrane fusion#GO:0061025;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;vesicle-mediated transport#GO:0016192;organelle fusion#GO:0048284;organelle membrane fusion#GO:0090174;membrane organization#GO:0061024;intracellular transport#GO:0046907;transport#GO:0006810;intracellular protein transport#GO:0006886;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;vesicle organization#GO:0016050;exocytosis#GO:0006887;intracellular protein localization#GO:0008104;cellular component organization#GO:0016043;vesicle fusion#GO:0006906;export from cell#GO:0140352;cellular localization#GO:0051641;secretion#GO:0046903;localization#GO:0051179;protein transport#GO:0015031;secretion by cell#GO:0032940 intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;SNARE complex#GO:0031201;endomembrane system#GO:0012505;cytoplasm#GO:0005737;plasma membrane#GO:0005886;membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944 SNARE protein#PC00034 Metabotropic glutamate receptor group III pathway#P00039>SNARE Complex#P01042;Nicotinic acetylcholine receptor signaling pathway#P00044>SNARE Complex#P01091;Synaptic vesicle trafficking#P05734>Syntaxin 1/2#P05772;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>SNARE Complex#P01066;Metabotropic glutamate receptor group II pathway#P00040>SNARE Complex#P01049;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>SNARE Complex#P01079 HUMAN|HGNC=10632|UniProtKB=P13501 P13501 CCL5 PTHR12015:SF170 SMALL INDUCIBLE CYTOKINE A C-C MOTIF CHEMOKINE 5 signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;chemokine activity#GO:0008009;G protein-coupled receptor binding#GO:0001664;protein binding#GO:0005515;chemokine receptor binding#GO:0042379;molecular function activator activity#GO:0140677;signaling receptor binding#GO:0005102;cytokine receptor binding#GO:0005126;binding#GO:0005488;cytokine activity#GO:0005125 signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;granulocyte chemotaxis#GO:0071621;response to stimulus#GO:0050896;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;positive regulation of cell motility#GO:2000147;response to peptide#GO:1901652;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;immune system process#GO:0002376;defense response to other organism#GO:0098542;granulocyte migration#GO:0097530;taxis#GO:0042330;response to cytokine#GO:0034097;response to chemical#GO:0042221;cellular process#GO:0009987;defense response to symbiont#GO:0140546;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;response to stress#GO:0006950;response to chemokine#GO:1990868;response to biotic stimulus#GO:0009607;cell surface receptor signaling pathway#GO:0007166;humoral immune response#GO:0006959;antimicrobial humoral response#GO:0019730;cellular response to chemokine#GO:1990869;locomotion#GO:0040011;response to external biotic stimulus#GO:0043207;regulation of cellular process#GO:0050794;cell motility#GO:0048870;cellular response to stimulus#GO:0051716;cell chemotaxis#GO:0060326;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;cell communication#GO:0007154;regulation of cell motility#GO:2000145;chemokine-mediated signaling pathway#GO:0070098;inflammatory response#GO:0006954;chemotaxis#GO:0006935;cytokine-mediated signaling pathway#GO:0019221;response to other organism#GO:0051707;regulation of locomotion#GO:0040012;biological regulation#GO:0065007;cell migration#GO:0016477;positive regulation of cell migration#GO:0030335;immune response#GO:0006955;positive regulation of cellular process#GO:0048522;leukocyte chemotaxis#GO:0030595;defense response#GO:0006952;myeloid leukocyte migration#GO:0097529;positive regulation of locomotion#GO:0040017;response to external stimulus#GO:0009605;regulation of cell migration#GO:0030334;leukocyte migration#GO:0050900 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 cytokine#PC00083 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CHK#P00856 HUMAN|Ensembl=ENSG00000277630.4|UniProtKB=A0AAG2SVG9 A0AAG2SVG9 LOC100288966 PTHR24147:SF66 ANKYRIN REPEAT DOMAIN 36-RELATED CCDC144C-LIKE COILED-COIL DOMAIN-CONTAINING PROTEIN-RELATED HUMAN|HGNC=32525|UniProtKB=A6NHY2 A6NHY2 ANKDD1B PTHR24125:SF1 ANKYRIN REPEAT AND DEATH DOMAIN-CONTAINING PROTEIN ANKYRIN REPEAT AND DEATH DOMAIN-CONTAINING PROTEIN 1B HUMAN|HGNC=9685|UniProtKB=P23471 P23471 PTPRZ1 PTHR19134:SF461 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE ZETA protein tyrosine phosphatase activity#GO:0004725;hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791 regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;system development#GO:0048731;cell communication#GO:0007154;anatomical structure development#GO:0048856;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;multicellular organismal process#GO:0032501;glial cell differentiation#GO:0010001;oligodendrocyte differentiation#GO:0048709;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;developmental process#GO:0032502;signaling#GO:0023052;cell development#GO:0048468;response to stimulus#GO:0050896;cell projection organization#GO:0030030;cell differentiation#GO:0030154;central nervous system development#GO:0007417;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;neuron development#GO:0048666;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;nervous system development#GO:0007399;signal transduction#GO:0007165;cellular process#GO:0009987;neuron projection development#GO:0031175;gliogenesis#GO:0042063;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;neuron differentiation#GO:0030182 protein modifying enzyme#PC00260;protein phosphatase#PC00195 HUMAN|HGNC=13102|UniProtKB=P17032 P17032 ZNF37A PTHR24377:SF1035 IP01015P-RELATED ZINC FINGER PROTEIN 37A sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=4854|UniProtKB=O15379 O15379 HDAC3 PTHR10625:SF36 HISTONE DEACETYLASE HDAC1-RELATED HISTONE DEACETYLASE 3 catalytic activity#GO:0003824;deacylase activity#GO:0160215;histone deacetylase activity#GO:0004407;histone modifying activity#GO:0140993;deacetylase activity#GO:0019213;catalytic activity, acting on a protein#GO:0140096 regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;chromatin remodeling#GO:0006338;biological regulation#GO:0065007;chromatin organization#GO:0006325;cellular component organization#GO:0016043;epigenetic regulation of gene expression#GO:0040029;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;cellular process#GO:0009987;regulation of biological process#GO:0050789 membrane-enclosed lumen#GO:0031974;histone deacetylase complex#GO:0000118;nucleus#GO:0005634;protein-containing complex#GO:0032991;nuclear protein-containing complex#GO:0140513;organelle lumen#GO:0043233;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 Wnt signaling pathway#P00057>Histone deacetylase#P01472 HUMAN|HGNC=40039|UniProtKB=A8MUM7 A8MUM7 LGALS16 PTHR11346:SF166 GALECTIN GALECTIN-16 carbohydrate binding#GO:0030246;binding#GO:0005488 extracellular matrix protein#PC00102 HUMAN|HGNC=13155|UniProtKB=P51504 P51504 ZNF80 PTHR24381:SF111 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 80 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=13504|UniProtKB=Q8N6H7 Q8N6H7 ARFGAP2 PTHR45686:SF10 ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 2 enzyme activator activity#GO:0008047;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096 organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;membrane organization#GO:0061024;Golgi vesicle transport#GO:0048193;transport#GO:0006810;cellular component organization or biogenesis#GO:0071840;localization#GO:0051179;establishment of localization#GO:0051234;vesicle budding from membrane#GO:0006900;vesicle organization#GO:0016050 GTPase-activating protein#PC00257;protein-binding activity modulator#PC00095 HUMAN|HGNC=11399|UniProtKB=P51957 P51957 NEK4 PTHR24361:SF859 MITOGEN-ACTIVATED KINASE KINASE KINASE SERINE_THREONINE-PROTEIN KINASE NEK4 catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 positive regulation of canonical Wnt signaling pathway#GO:0090263;regulation of monoatomic cation transmembrane transport#GO:1904062;DNA damage response#GO:0006974;regulation of response to stimulus#GO:0048583;positive regulation of response to stimulus#GO:0048584;regulation of monoatomic ion transport#GO:0043269;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of cellular process#GO:0048522;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;positive regulation of signal transduction#GO:0009967;regulation of transmembrane transport#GO:0034762;cellular response to stimulus#GO:0051716;regulation of transport#GO:0051049;regulation of localization#GO:0032879;positive regulation of Wnt signaling pathway#GO:0030177;response to stress#GO:0006950;regulation of canonical Wnt signaling pathway#GO:0060828;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;regulation of monoatomic ion transmembrane transport#GO:0034765;cellular process#GO:0009987;positive regulation of signaling#GO:0023056;cellular response to stress#GO:0033554;regulation of signaling#GO:0023051;response to stimulus#GO:0050896;signaling#GO:0023052;regulation of Wnt signaling pathway#GO:0030111;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=19982|UniProtKB=A4D1S5 A4D1S5 RAB19 PTHR24073:SF362 DRAB5-RELATED RAS-RELATED PROTEIN RAB-19 ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818 establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;macromolecule localization#GO:0033036;intracellular protein localization#GO:0008104;protein transport#GO:0015031;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 G-protein#PC00020;small GTPase#PC00208 HUMAN|HGNC=361|UniProtKB=P00568 P00568 AK1 PTHR23359:SF59 NUCLEOTIDE KINASE ADENYLATE KINASE ISOENZYME 1 catalytic activity#GO:0003824;transferase activity#GO:0016740;nucleobase-containing compound kinase activity#GO:0019205;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, phosphate group as acceptor#GO:0016776 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 nucleotide kinase#PC00172;kinase#PC00137 De novo purine biosynthesis#P02738>Adenylate kinase#P02896 HUMAN|HGNC=3065|UniProtKB=Q9Y6W6 Q9Y6W6 DUSP10 PTHR10159:SF299 DUAL SPECIFICITY PROTEIN PHOSPHATASE DUAL SPECIFICITY PROTEIN PHOSPHATASE 10 protein tyrosine phosphatase activity#GO:0004725;hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721;protein tyrosine/serine/threonine phosphatase activity#GO:0008138;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578 negative regulation of response to stimulus#GO:0048585;negative regulation of signal transduction#GO:0009968;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of JNK cascade#GO:0046328;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of MAPK cascade#GO:0043408;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of cell communication#GO:0010646;signaling#GO:0023052;negative regulation of biological process#GO:0048519;negative regulation of MAPK cascade#GO:0043409;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;negative regulation of intracellular signal transduction#GO:1902532;cell communication#GO:0007154;negative regulation of cell communication#GO:0010648;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195 p38 MAPK pathway#P05918>MKP5#P05921;Oxidative stress response#P00046>MKP5#P01131 HUMAN|HGNC=25189|UniProtKB=Q96BT7 Q96BT7 ALKBH8 PTHR13069:SF21 ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8 TRNA (CARBOXYMETHYLURIDINE(34)-5-O)-METHYLTRANSFERASE ALKBH8 RNA binding#GO:0003723;tRNA binding#GO:0000049;catalytic activity, acting on a tRNA#GO:0140101;methyltransferase activity#GO:0008168;nucleic acid binding#GO:0003676;binding#GO:0005488;tRNA methyltransferase activity#GO:0008175;catalytic activity, acting on RNA#GO:0140098;RNA methyltransferase activity#GO:0008173;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;transferase activity#GO:0016740 metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;tRNA methylation#GO:0030488;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;macromolecule methylation#GO:0043414;RNA modification#GO:0009451;methylation#GO:0032259;RNA metabolic process#GO:0016070;RNA methylation#GO:0001510;macromolecule modification#GO:0043412;tRNA wobble uridine modification#GO:0002098;tRNA wobble base modification#GO:0002097;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;tRNA modification#GO:0006400 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HUMAN|HGNC=1698|UniProtKB=P11912 P11912 CD79A PTHR14334:SF1 B-CELL ANTIGEN RECEPTOR COMPLEX-ASSOCIATED PROTEIN B-CELL ANTIGEN RECEPTOR COMPLEX-ASSOCIATED PROTEIN ALPHA CHAIN transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 regulation of biological process#GO:0050789;immune response-regulating signaling pathway#GO:0002764;mononuclear cell differentiation#GO:1903131;leukocyte differentiation#GO:0002521;signaling#GO:0023052;cell development#GO:0048468;response to stimulus#GO:0050896;cell differentiation#GO:0030154;immune system process#GO:0002376;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;signal transduction#GO:0007165;cellular process#GO:0009987;B cell receptor signaling pathway#GO:0050853;positive regulation of immune system process#GO:0002684;antigen receptor-mediated signaling pathway#GO:0050851;lymphocyte activation#GO:0046649;cell surface receptor signaling pathway#GO:0007166;B cell activation#GO:0042113;immune response-activating signaling pathway#GO:0002757;cellular response to stimulus#GO:0051716;leukocyte activation#GO:0045321;immune response-activating cell surface receptor signaling pathway#GO:0002429;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of immune response#GO:0050776;lymphocyte differentiation#GO:0030098;cell activation#GO:0001775;cell communication#GO:0007154;anatomical structure development#GO:0048856;immune response-regulating cell surface receptor signaling pathway#GO:0002768;hemopoiesis#GO:0030097;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;multicellular organismal process#GO:0032501;developmental process#GO:0032502;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;cellular developmental process#GO:0048869 signaling receptor complex#GO:0043235;external side of plasma membrane#GO:0009897;side of membrane#GO:0098552;membrane protein complex#GO:0098796;membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 B cell activation#P00010>Ig-alpha#P00399 HUMAN|HGNC=28983|UniProtKB=Q12767 Q12767 TMEM94 PTHR13219:SF6 TRANSMEMBRANE PROTEIN 94 TRANSMEMBRANE PROTEIN 94 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;P-type ion transporter activity#GO:0015662;monoatomic ion transmembrane transporter activity#GO:0015075;ATPase-coupled transmembrane transporter activity#GO:0042626;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATP-dependent activity#GO:0140657;magnesium ion transmembrane transporter activity#GO:0015095;monoatomic cation transmembrane transporter activity#GO:0008324 establishment of localization in cell#GO:0051649;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;monoatomic ion transmembrane transport#GO:0034220;magnesium ion transport#GO:0015693;intracellular transport#GO:0046907;transport#GO:0006810;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;cellular localization#GO:0051641;monoatomic ion transport#GO:0006811 endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=6721|UniProtKB=P29376 P29376 LTK PTHR24416:SF294 TYROSINE-PROTEIN KINASE RECEPTOR LEUKOCYTE TYROSINE KINASE RECEPTOR catalytic activity, acting on a protein#GO:0140096;signaling receptor activity#GO:0038023;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein tyrosine kinase activity#GO:0004713;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773;molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;regulation of developmental process#GO:0050793;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;enzyme-linked receptor protein signaling pathway#GO:0007167;signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;regulation of neuron differentiation#GO:0045664;regulation of cell differentiation#GO:0045595;cell surface receptor signaling pathway#GO:0007166 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;signaling receptor complex#GO:0043235 transmembrane signal receptor#PC00197 HUMAN|HGNC=30219|UniProtKB=A6NM36 A6NM36 LRRC30 PTHR45752:SF35 LEUCINE-RICH REPEAT-CONTAINING LEUCINE-RICH REPEAT-CONTAINING PROTEIN 30 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 scaffold/adaptor protein#PC00226 HUMAN|HGNC=29503|UniProtKB=Q96JN0 Q96JN0 LCOR PTHR21545:SF14 TRANSCRIPTION FACTOR MLR1/2 LIGAND-DEPENDENT COREPRESSOR regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218 HUMAN|HGNC=23204|UniProtKB=Q8IZU9 Q8IZU9 KIRREL3 PTHR11640:SF49 NEPHRIN KIN OF IRRE-LIKE PROTEIN 3 cell adhesion molecule binding#GO:0050839;binding#GO:0005488;protein binding#GO:0005515 cellular component biogenesis#GO:0044085;cell-cell adhesion#GO:0098609;cellular process#GO:0009987;cellular component assembly#GO:0022607;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;developmental process#GO:0032502;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cell junction assembly#GO:0034329;cellular component organization#GO:0016043;synapse assembly#GO:0007416;cell junction organization#GO:0034330;animal gross anatomical part developmental process#GO:0160108;cell adhesion#GO:0007155;synapse organization#GO:0050808;anatomical structure development#GO:0048856;system development#GO:0048731 cellular anatomical structure#GO:0110165;cell junction#GO:0030054;anchoring junction#GO:0070161;plasma membrane#GO:0005886;cell-cell junction#GO:0005911;membrane#GO:0016020;cell periphery#GO:0071944 cell adhesion molecule#PC00069;immunoglobulin superfamily cell adhesion molecule#PC00125 HUMAN|HGNC=15301|UniProtKB=O95222 O95222 OR6A2 PTHR26453:SF234 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 6A2 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 response to chemical#GO:0042221;response to stimulus#GO:0050896;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;detection of chemical stimulus#GO:0009593;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;system process#GO:0003008;sensory perception#GO:0007600;nervous system process#GO:0050877;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=33147|UniProtKB=Q9BPZ2 Q9BPZ2 SPIN2B PTHR10405:SF13 SPINDLIN SPINDLIN-2A-RELATED chromatin-protein adaptor activity#GO:0140463;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;histone H3 reader activity#GO:0140006;histone reader activity#GO:0140566 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794 nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=31989|UniProtKB=P0C2Y1 P0C2Y1 NBPF7P PTHR14199:SF42 NEUROBLASTOMA BREAKPOINT FAMILY MEMBER 6-LIKE PROTEIN NBPF FAMILY MEMBER NBPF7-RELATED HUMAN|HGNC=13718|UniProtKB=P15407 P15407 FOSL1 PTHR23351:SF6 FOS TRANSCRIPTION FACTOR-RELATED FOS-RELATED ANTIGEN 1 DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 basic leucine zipper transcription factor#PC00056 TGF-beta signaling pathway#P00052>Co-activators corepressors#P01282 HUMAN|HGNC=33293|UniProtKB=P0C2W7 P0C2W7 CT47B1 PTHR32157:SF5 GENE 6268-RELATED CANCER_TESTIS ANTIGEN FAMILY 47 MEMBER B1 HUMAN|HGNC=29299|UniProtKB=Q9P217 Q9P217 ZSWIM5 PTHR22619:SF2 ZINC FINGER SWIM DOMAIN CONTAINING PROTEIN 4, 5, 6 ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 5 Cul2-RING ubiquitin ligase complex#GO:0031462;catalytic complex#GO:1902494;transferase complex#GO:1990234;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461 HUMAN|HGNC=51899|UniProtKB=H7C350 H7C350 CCDC188 PTHR22422:SF6 TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 5B-RELATED COILED-COIL DOMAIN-CONTAINING PROTEIN 188 HUMAN|HGNC=25521|UniProtKB=Q8N5C6 Q8N5C6 SRBD1 PTHR10724:SF10 30S RIBOSOMAL PROTEIN S1 S1 RNA-BINDING DOMAIN-CONTAINING PROTEIN 1 structural molecule activity#GO:0005198;RNA binding#GO:0003723;binding#GO:0005488;structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;translation#GO:0006412;metabolic process#GO:0008152;biosynthetic process#GO:0009058;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238 ribosomal protein#PC00202 HUMAN|HGNC=24240|UniProtKB=Q99999 Q99999 GAL3ST1 PTHR14647:SF56 GALACTOSE-3-O-SULFOTRANSFERASE GALACTOSYLCERAMIDE SULFOTRANSFERASE sulfotransferase activity#GO:0008146;transferase activity, transferring sulphur-containing groups#GO:0016782;catalytic activity#GO:0003824;transferase activity#GO:0016740 system development#GO:0048731;glycolipid biosynthetic process#GO:0009247;ceramide metabolic process#GO:0006672;anatomical structure development#GO:0048856;glycosphingolipid biosynthetic process#GO:0006688;animal gross anatomical part developmental process#GO:0160108;liposaccharide metabolic process#GO:1903509;glycolipid metabolic process#GO:0006664;primary metabolic process#GO:0044238;myelination#GO:0042552;multicellular organism development#GO:0007275;carbohydrate derivative biosynthetic process#GO:1901137;developmental process#GO:0032502;ceramide biosynthetic process#GO:0046513;lipid metabolic process#GO:0006629;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;sphingolipid biosynthetic process#GO:0030148;biosynthetic process#GO:0009058;nervous system development#GO:0007399;lipid biosynthetic process#GO:0008610;multicellular organismal process#GO:0032501;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987 transferase#PC00220 HUMAN|HGNC=12976|UniProtKB=O15231 O15231 ZNF185 PTHR15468:SF2 ZNF185 ZINC FINGER PROTEIN 185 HUMAN|HGNC=24466|UniProtKB=O15061 O15061 SYNM PTHR47136:SF1 SYNEMIN SYNEMIN structural constituent of cytoskeleton#GO:0005200;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;structural molecule activity#GO:0005198 multicellular organismal process#GO:0032501;skeletal muscle contraction#GO:0003009;striated muscle contraction#GO:0006941;muscle system process#GO:0003012;system process#GO:0003008;neuromuscular process#GO:0050905;muscle contraction#GO:0006936;nervous system process#GO:0050877 supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;myofibril#GO:0030016;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intermediate filament#GO:0005882;sarcolemma#GO:0042383;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;contractile muscle fiber#GO:0043292;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=28537|UniProtKB=Q8N6L7 Q8N6L7 TMEM252 PTHR35682:SF1 TRANSMEMBRANE PROTEIN 252 TRANSMEMBRANE PROTEIN 252 HUMAN|HGNC=600|UniProtKB=P02647 P02647 APOA1 PTHR18976:SF11 APOLIPOPROTEIN APOLIPOPROTEIN A-I lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104;binding#GO:0005488;molecular function activator activity#GO:0140677;lipid binding#GO:0008289;lipid transfer activity#GO:0120013;enzyme regulator activity#GO:0030234;sterol transfer activity#GO:0120015;transporter activity#GO:0005215;enzyme activator activity#GO:0008047;phospholipid binding#GO:0005543;molecular function regulator activity#GO:0098772;cholesterol transfer activity#GO:0120020 secondary alcohol metabolic process#GO:1902652;homeostatic process#GO:0042592;organophosphate ester transport#GO:0015748;small molecule metabolic process#GO:0044281;primary metabolic process#GO:0044238;lipid homeostasis#GO:0055088;organic hydroxy compound transport#GO:0015850;localization#GO:0051179;lipid localization#GO:0010876;phospholipid transport#GO:0015914;steroid metabolic process#GO:0008202;lipid transport#GO:0006869;cholesterol efflux#GO:0033344;cellular process#GO:0009987;cholesterol transport#GO:0030301;macromolecule localization#GO:0033036;sterol transport#GO:0015918;establishment of localization#GO:0051234;sterol metabolic process#GO:0016125;chemical homeostasis#GO:0048878;lipid metabolic process#GO:0006629;transport#GO:0006810;cholesterol metabolic process#GO:0008203;alcohol metabolic process#GO:0006066;metabolic process#GO:0008152 plasma lipoprotein particle#GO:0034358;membrane-bounded organelle#GO:0043227;high-density lipoprotein particle#GO:0034364;extracellular region#GO:0005576;extracellular protein-containing complex#GO:0140392;protein-lipid complex#GO:0032994;lipoprotein particle#GO:1990777;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;very-low-density lipoprotein particle#GO:0034361;vesicle#GO:0031982 transfer/carrier protein#PC00219;apolipoprotein#PC00052 HUMAN|HGNC=17869|UniProtKB=Q9UHB7 Q9UHB7 AFF4 PTHR10528:SF15 AF4/FMR2 FAMILY MEMBER AF4_FMR2 FAMILY MEMBER 4 transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;nervous system process#GO:0050877;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;system process#GO:0003008;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;regulation of RNA biosynthetic process#GO:2001141;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;biosynthetic process#GO:0009058;regulation of nucleobase-containing compound metabolic process#GO:0019219;gene expression#GO:0010467;multicellular organismal process#GO:0032501;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;DNA-templated transcription elongation#GO:0006354;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membrane-bounded organelle#GO:0043231;transcription elongation factor complex#GO:0008023;protein-containing complex#GO:0032991;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HUMAN|HGNC=5476|UniProtKB=Q16270 Q16270 IGFBP7 PTHR14186:SF19 INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-RELATED INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 7 signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772 system development#GO:0048731;angiogenesis#GO:0001525;anatomical structure development#GO:0048856;regulation of signaling#GO:0023051;animal gross anatomical part developmental process#GO:0160108;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;circulatory system development#GO:0072359;tube morphogenesis#GO:0035239;blood vessel development#GO:0001568;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;blood vessel morphogenesis#GO:0048514;vasculature development#GO:0001944;anatomical structure formation involved in morphogenesis#GO:0048646;multicellular organism development#GO:0007275;regulation of response to stimulus#GO:0048583;developmental process#GO:0032502;tube development#GO:0035295;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;multicellular organismal process#GO:0032501 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=638|UniProtKB=P55064 P55064 AQP5 PTHR19139:SF38 AQUAPORIN TRANSPORTER AQUAPORIN-5 channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;water channel activity#GO:0015250;water transmembrane transporter activity#GO:0005372 transport#GO:0006810;fluid transport#GO:0042044;water transport#GO:0006833;localization#GO:0051179;establishment of localization#GO:0051234 cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;plasma membrane#GO:0005886;membrane#GO:0016020;apical plasma membrane#GO:0016324;cell periphery#GO:0071944;apical part of cell#GO:0045177 transporter#PC00227 HUMAN|HGNC=25013|UniProtKB=Q9P003 Q9P003 CNIH4 PTHR12290:SF19 CORNICHON-RELATED PROTEIN CORNICHON HOMOLOG 4 establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;transport#GO:0006810;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649 COPII-coated ER to Golgi transport vesicle#GO:0030134;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;coated vesicle#GO:0030135;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endomembrane system#GO:0012505;cytoplasm#GO:0005737;membrane#GO:0016020 membrane traffic protein#PC00150 HUMAN|HGNC=11641|UniProtKB=Q9NQB0 Q9NQB0 TCF7L2 PTHR10373:SF32 TRANSCRIPTION FACTOR 7 FAMILY MEMBER TRANSCRIPTION FACTOR 7-LIKE 2 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 cell surface receptor signaling pathway#GO:0007166;regulation of canonical Wnt signaling pathway#GO:0060828;cellular process#GO:0009987;signal transduction#GO:0007165;negative regulation of signal transduction#GO:0009968;negative regulation of signaling#GO:0023057;negative regulation of canonical Wnt signaling pathway#GO:0090090;regulation of signaling#GO:0023051;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;regulation of Wnt signaling pathway#GO:0030111;signaling#GO:0023052;negative regulation of cellular process#GO:0048523;regulation of carbohydrate metabolic process#GO:0006109;regulation of response to stimulus#GO:0048583;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;negative regulation of response to stimulus#GO:0048585;negative regulation of Wnt signaling pathway#GO:0030178;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of RNA biosynthetic process#GO:2001141;regulation of DNA-templated transcription#GO:0006355;cell communication#GO:0007154;canonical Wnt signaling pathway#GO:0060070;regulation of RNA metabolic process#GO:0051252;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;Wnt signaling pathway#GO:0016055;regulation of macromolecule metabolic process#GO:0060255;regulation of cell communication#GO:0010646;regulation of carbohydrate biosynthetic process#GO:0043255 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;chromatin#GO:0000785;nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 Wnt signaling pathway#P00057>Wnt Target Genes#G01558;Wnt signaling pathway#P00057>TCF#P01437;Alzheimer disease-presenilin pathway#P00004>TCF/LEF#P00143;Angiogenesis#P00005>TCF#P00242;Cadherin signaling pathway#P00012>TCF/LEF#P00465 HUMAN|HGNC=11114|UniProtKB=P41229 P41229 KDM5C PTHR10694:SF43 LYSINE-SPECIFIC DEMETHYLASE LYSINE-SPECIFIC DEMETHYLASE 5C histone modifying activity#GO:0140993;dioxygenase activity#GO:0051213;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;histone demethylase activity#GO:0032452;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491;demethylase activity#GO:0032451;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;protein demethylase activity#GO:0140457 chromatin remodeling#GO:0006338;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;chromosome#GO:0005694;nucleus#GO:0005634;chromatin#GO:0000785;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231 histone modifying enzyme#PC00261 HUMAN|HGNC=21754|UniProtKB=Q9H2L4 Q9H2L4 TMEM60 PTHR13568:SF4 FAM11A, B PROTEIN TRANSMEMBRANE PROTEIN 60 HUMAN|HGNC=11907|UniProtKB=Q9UBN6 Q9UBN6 TNFRSF10D PTHR46330:SF10 TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10B TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10D biological regulation#GO:0065007;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165;cellular process#GO:0009987;positive regulation of apoptotic process#GO:0043065;apoptotic signaling pathway#GO:0097190;extrinsic apoptotic signaling pathway via death domain receptors#GO:0008625;regulation of apoptotic process#GO:0042981;cell surface receptor signaling pathway#GO:0007166;response to stimulus#GO:0050896;extrinsic apoptotic signaling pathway#GO:0097191;regulation of cellular process#GO:0050794;positive regulation of programmed cell death#GO:0043068;signaling#GO:0023052;regulation of programmed cell death#GO:0043067;programmed cell death#GO:0012501;regulation of biological process#GO:0050789;cell death#GO:0008219;apoptotic process#GO:0006915;cellular response to stimulus#GO:0051716;cell communication#GO:0007154 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cell surface#GO:0009986;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 p53 pathway#P00059>KILLER/DR5#G01568;Apoptosis signaling pathway#P00006>TRAIL-R#P00276 HUMAN|HGNC=11016|UniProtKB=O15431 O15431 SLC31A1 PTHR12483:SF22 SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS HIGH AFFINITY COPPER UPTAKE PROTEIN 1 monoatomic cation transmembrane transporter activity#GO:0008324;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;transition metal ion transmembrane transporter activity#GO:0046915 transition metal ion transport#GO:0000041;transport#GO:0006810;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;monoatomic cation transport#GO:0006812;cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;copper ion transmembrane transport#GO:0035434 membrane#GO:0016020;apical plasma membrane#GO:0016324;cell periphery#GO:0071944;apical part of cell#GO:0045177;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 HUMAN|HGNC=16716|UniProtKB=Q7L2E3 Q7L2E3 DHX30 PTHR18934:SF229 ATP-DEPENDENT RNA HELICASE ATP-DEPENDENT RNA HELICASE DHX30 binding#GO:0005488;nucleic acid binding#GO:0003676;ATP-dependent activity#GO:0140657;RNA binding#GO:0003723;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;macromolecular conformation isomerase activity#GO:0120543;helicase activity#GO:0004386;isomerase activity#GO:0016853 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 RNA helicase#PC00032;RNA metabolism protein#PC00031 HUMAN|HGNC=19355|UniProtKB=Q6NYC1 Q6NYC1 JMJD6 PTHR12480:SF32 ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD BIFUNCTIONAL ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD6 localization#GO:0051179;endocytosis#GO:0006897;import into cell#GO:0098657;establishment of localization#GO:0051234;phagocytosis#GO:0006909;transport#GO:0006810 protein modifying enzyme#PC00260 HUMAN|HGNC=6562|UniProtKB=P05162 P05162 LGALS2 PTHR11346:SF104 GALECTIN GALECTIN-2 carbohydrate binding#GO:0030246;carbohydrate derivative binding#GO:0097367;binding#GO:0005488 extracellular matrix protein#PC00102 HUMAN|HGNC=20815|UniProtKB=Q9Y4C1 Q9Y4C1 KDM3A PTHR12549:SF7 JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROTEIN LYSINE-SPECIFIC DEMETHYLASE 3A transcription regulator activity#GO:0140110;chromatin binding#GO:0003682;binding#GO:0005488;nucleic acid binding#GO:0003676;histone modifying activity#GO:0140993;DNA binding#GO:0003677;chromatin DNA binding#GO:0031490;histone demethylase activity#GO:0032452;transcription coregulator activity#GO:0003712;catalytic activity#GO:0003824;protein demethylase activity#GO:0140457;catalytic activity, acting on a protein#GO:0140096;demethylase activity#GO:0032451 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694;chromatin#GO:0000785;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 histone modifying enzyme#PC00261 HUMAN|HGNC=16074|UniProtKB=Q9NX40 Q9NX40 OCIAD1 PTHR13336:SF4 OVARIAN CARCINOMA IMMUNOREACTIVE ANTIGEN OCIA DOMAIN-CONTAINING PROTEIN 1 intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410 membrane traffic protein#PC00150 HUMAN|HGNC=4882|UniProtKB=Q9NQ87 Q9NQ87 HEYL PTHR10985:SF79 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED HAIRY_ENHANCER-OF-SPLIT RELATED WITH YRPW MOTIF-LIKE PROTEIN sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987 multicellular organism development#GO:0007275;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;cell surface receptor signaling pathway#GO:0007166;anterior/posterior pattern specification#GO:0009952;regulation of multicellular organismal process#GO:0051239;cellular process#GO:0009987;signal transduction#GO:0007165;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;signaling#GO:0023052;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;regulation of multicellular organismal development#GO:2000026;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;Notch signaling pathway#GO:0007219;regulation of cell differentiation#GO:0045595;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;multicellular organismal process#GO:0032501;regionalization#GO:0003002;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cell development#GO:0060284;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of nervous system development#GO:0051960;cell communication#GO:0007154;pattern specification process#GO:0007389;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;cellular response to stimulus#GO:0051716;regulation of neurogenesis#GO:0050767 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 basic helix-loop-helix transcription factor#PC00055 Notch signaling pathway#P00045>E(spl)-C genes#G01541 HUMAN|HGNC=13770|UniProtKB=Q8TDY8 Q8TDY8 IGDCC4 PTHR10075:SF132 BASIGIN RELATED IMMUNOGLOBULIN SUPERFAMILY DCC SUBCLASS MEMBER 4 cell adhesion molecule#PC00069 HUMAN|HGNC=53960|UniProtKB=A0A3B3IU63 A0A3B3IU63 H2AL3 PTHR23430:SF11 HISTONE H2A HISTONE H2A-RELATED structural molecule activity#GO:0005198 chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;heterochromatin formation#GO:0031507;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of gene expression, epigenetic#GO:0045814;cellular component organization or biogenesis#GO:0071840;negative regulation of cellular process#GO:0048523;heterochromatin organization#GO:0070828;chromatin organization#GO:0006325;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;cellular component assembly#GO:0022607;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;epigenetic regulation of gene expression#GO:0040029;regulation of macromolecule biosynthetic process#GO:0010556;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558 intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;chromosome#GO:0005694;chromatin#GO:0000785;nucleus#GO:0005634;protein-DNA complex#GO:0032993;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleosome#GO:0000786;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=10063|UniProtKB=Q9BYJ4 Q9BYJ4 TRIM34 PTHR24103:SF647 E3 UBIQUITIN-PROTEIN LIGASE TRIM E3 UBIQUITIN-PROTEIN LIGASE TRIM34 acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 regulation of biological process#GO:0050789;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;regulation of macromolecule metabolic process#GO:0060255;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;immune system process#GO:0002376;immune response#GO:0006955;defense response to symbiont#GO:0140546;response to biotic stimulus#GO:0009607;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;response to stress#GO:0006950;biological regulation#GO:0065007;response to other organism#GO:0051707;defense response to other organism#GO:0098542;response to external stimulus#GO:0009605;defense response#GO:0006952;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;innate immune response#GO:0045087 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=29208|UniProtKB=Q8TAM6 Q8TAM6 ERMN PTHR47137:SF1 ERMIN ERMIN protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;actin filament binding#GO:0051015 cellular process#GO:0009987;morphogenesis of a branching structure#GO:0001763;organelle organization#GO:0006996;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;multicellular organismal process#GO:0032501;developmental process#GO:0032502;regulation of cell projection organization#GO:0031344;actin filament organization#GO:0007015;regulation of anatomical structure morphogenesis#GO:0022603;cellular component organization or biogenesis#GO:0071840;regulation of cell shape#GO:0008360;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;actin cytoskeleton organization#GO:0030036;regulation of cellular component organization#GO:0051128;actin filament-based process#GO:0030029;regulation of biological quality#GO:0065008;supramolecular fiber organization#GO:0097435;anatomical structure development#GO:0048856 actin-based cell projection#GO:0098858;cell cortex#GO:0005938;cell body#GO:0044297;actin cytoskeleton#GO:0015629;plasma membrane bounded cell projection#GO:0120025;neuronal cell body#GO:0043025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;axon#GO:0030424;intracellular organelle#GO:0043229;filopodium#GO:0030175;intracellular anatomical structure#GO:0005622;cell periphery#GO:0071944;main axon#GO:0044304;neuron projection#GO:0043005;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;myelin sheath#GO:0043209;somatodendritic compartment#GO:0036477;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228 HUMAN|HGNC=26422|UniProtKB=Q96NG5 Q96NG5 ZNF558 PTHR24381:SF80 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 558 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=10717|UniProtKB=Q9UBV2 Q9UBV2 SEL1L PTHR11102:SF70 SEL-1-LIKE PROTEIN PROTEIN SEL-1 HOMOLOG 1 macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;response to chemical#GO:0042221;proteasomal protein catabolic process#GO:0010498;response to stress#GO:0006950;cellular process#GO:0009987;protein metabolic process#GO:0019538;ERAD pathway#GO:0036503;response to endoplasmic reticulum stress#GO:0034976;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;catabolic process#GO:0009056;response to stimulus#GO:0050896;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716 endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175 HUMAN|HGNC=2196|UniProtKB=Q14993 Q14993 COL19A1 PTHR24023:SF938 COLLAGEN ALPHA COLLAGEN ALPHA-1(XIX) CHAIN extracellular matrix structural constituent#GO:0005201;structural molecule activity#GO:0005198 extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;external encapsulating structure organization#GO:0045229;cellular component organization#GO:0016043;extracellular structure organization#GO:0043062;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 extracellular matrix structural protein#PC00103;extracellular matrix protein#PC00102 HUMAN|HGNC=10289|UniProtKB=P27694 P27694 RPA1 PTHR23273:SF4 REPLICATION FACTOR A 1, RFA1 REPLICATION PROTEIN A 70 KDA DNA-BINDING SUBUNIT single-stranded DNA binding#GO:0003697;damaged DNA binding#GO:0003684;nucleic acid binding#GO:0003676;binding#GO:0005488;telomeric repeat DNA binding#GO:0042162;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677 response to stimulus#GO:0050896;double-strand break repair via homologous recombination#GO:0000724;cellular component organization#GO:0016043;cellular response to stress#GO:0033554;nucleic acid biosynthetic process#GO:0141187;nucleotide-excision repair#GO:0006289;telomere maintenance via telomerase#GO:0007004;telomere maintenance via telomere lengthening#GO:0010833;cellular process#GO:0009987;DNA biosynthetic process#GO:0071897;response to stress#GO:0006950;organelle organization#GO:0006996;double-strand break repair#GO:0006302;cellular component organization or biogenesis#GO:0071840;DNA recombination#GO:0006310;DNA metabolic process#GO:0006259;nucleobase-containing compound biosynthetic process#GO:0034654;meiotic cell cycle#GO:0051321;metabolic process#GO:0008152;reproductive process#GO:0022414;DNA replication#GO:0006260;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cell cycle#GO:0007049;telomere organization#GO:0032200;sexual reproduction#GO:0019953;recombinational repair#GO:0000725;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;macromolecule biosynthetic process#GO:0009059;telomere maintenance#GO:0000723;chromosome organization#GO:0051276;macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;RNA-templated DNA biosynthetic process#GO:0006278;DNA repair#GO:0006281 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nuclear replication fork#GO:0043596;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;replisome#GO:0030894;replication fork#GO:0005657;organelle lumen#GO:0043233;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-DNA complex#GO:0032993;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991 DNA metabolism protein#PC00009 HUMAN|HGNC=24827|UniProtKB=Q8TDS4 Q8TDS4 HCAR2 PTHR46048:SF6 HYDROXYCARBOXYLIC ACID RECEPTOR 2 HYDROXYCARBOXYLIC ACID RECEPTOR 2 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=15829|UniProtKB=Q9H5J4 Q9H5J4 ELOVL6 PTHR11157:SF125 FATTY ACID ACYL TRANSFERASE-RELATED VERY LONG CHAIN FATTY ACID ELONGASE 6 acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058;fatty acid biosynthetic process#GO:0006633;cellular process#GO:0009987;monocarboxylic acid biosynthetic process#GO:0072330;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;sphingolipid biosynthetic process#GO:0030148;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;small molecule metabolic process#GO:0044281;very long-chain fatty acid metabolic process#GO:0000038;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;carboxylic acid biosynthetic process#GO:0046394;oxoacid metabolic process#GO:0043436 organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020 acyltransferase#PC00042;transferase#PC00220 HUMAN|HGNC=15462|UniProtKB=Q9Y3S2 Q9Y3S2 ZNF330 PTHR13214:SF1 ZINC FINGER PROTEIN 330 ZINC FINGER PROTEIN 330 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=9244|UniProtKB=O14830 O14830 PPEF2 PTHR45668:SF2 SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED SERINE_THREONINE-PROTEIN PHOSPHATASE WITH EF-HANDS 2 protein binding#GO:0005515;heat shock protein binding#GO:0031072;Hsp90 protein binding#GO:0051879;binding#GO:0005488 regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;negative regulation of MAPK cascade#GO:0043409;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of MAPK cascade#GO:0043408;negative regulation of response to stimulus#GO:0048585;negative regulation of signal transduction#GO:0009968;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966 protein phosphatase#PC00195 HUMAN|HGNC=1616|UniProtKB=P49368 P49368 CCT3 PTHR11353:SF24 CHAPERONIN T-COMPLEX PROTEIN 1 SUBUNIT GAMMA macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;biosynthetic process#GO:0009058;protein folding#GO:0006457;protein maturation#GO:0051604;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238 chaperonin-containing T-complex#GO:0005832;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;protein folding chaperone complex#GO:0101031;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;cytosol#GO:0005829 chaperonin#PC00073 HUMAN|HGNC=7878|UniProtKB=Q9NZN8 Q9NZN8 CNOT2 PTHR23326:SF35 CCR4 NOT-RELATED CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 2 positive regulation of mRNA catabolic process#GO:0061014;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of developmental process#GO:0050793;positive regulation of RNA metabolic process#GO:0051254;nuclear-transcribed mRNA poly(A) tail shortening#GO:0000289;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA stability#GO:0043487;regulation of RNA metabolic process#GO:0051252;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;nucleic acid catabolic process#GO:0141188;nucleobase-containing compound catabolic process#GO:0034655;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;macromolecule metabolic process#GO:0043170;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;positive regulation of catabolic process#GO:0009896;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;negative regulation of gene expression#GO:0010629;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;regulation of mRNA stability#GO:0043488;RNA catabolic process#GO:0006401;regulation of biological quality#GO:0065008;positive regulation of metabolic process#GO:0009893;RNA metabolic process#GO:0016070;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;RNA destabilization#GO:0050779;regulation of multicellular organismal process#GO:0051239;positive regulation of macromolecule metabolic process#GO:0010604;metabolic process#GO:0008152;positive regulation of mRNA metabolic process#GO:1903313;macromolecule catabolic process#GO:0009057;mRNA destabilization#GO:0061157;regulation of mRNA metabolic process#GO:1903311 P-body#GO:0000932;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;CCR4-NOT complex#GO:0030014;protein-containing complex#GO:0032991;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;supramolecular complex#GO:0099080;organelle#GO:0043226;ribonucleoprotein granule#GO:0035770;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232 general transcription factor#PC00259;RNA metabolism protein#PC00031 HUMAN|HGNC=30768|UniProtKB=Q8TD23 Q8TD23 ZNF675 PTHR24384:SF115 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED ZINC FINGER PROTEIN 675 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 DNA-binding transcription factor#PC00218 HUMAN|HGNC=31828|UniProtKB=P63135 P63135 ERVK-7 PTHR41694:SF3 ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN ENDOGENOUS RETROVIRUS GROUP K MEMBER 10 POL PROTEIN-RELATED binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 viral or transposable element protein#PC00237 HUMAN|HGNC=25026|UniProtKB=Q8NEB5 Q8NEB5 PLPP5 PTHR10165:SF87 LIPID PHOSPHATE PHOSPHATASE PHOSPHOLIPID PHOSPHATASE 5 phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578 phospholipid metabolic process#GO:0006644;organophosphate metabolic process#GO:0019637;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;phospholipid dephosphorylation#GO:0046839;phosphate-containing compound metabolic process#GO:0006796;cellular process#GO:0009987;dephosphorylation#GO:0016311;lipid modification#GO:0030258;metabolic process#GO:0008152;lipid metabolic process#GO:0006629 cellular anatomical structure#GO:0110165;membrane#GO:0016020 hydrolase#PC00121;phosphatase#PC00181 HUMAN|HGNC=26053|UniProtKB=Q9NWX6 Q9NWX6 THG1L PTHR12729:SF6 TRNA(HIS) GUANYLYLTRANSFERASE-RELATED TRNA(HIS) GUANYLYLTRANSFERASE-RELATED catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098;transferase activity, transferring phosphorus-containing groups#GO:0016772;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;transferase activity#GO:0016740 nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;gene expression#GO:0010467 HUMAN|HGNC=7330|UniProtKB=O43347 O43347 MSI1 PTHR48032:SF3 RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6 RNA-BINDING PROTEIN MUSASHI HOMOLOG 1 RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676 regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;post-transcriptional regulation of gene expression#GO:0010608;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=15893|UniProtKB=Q9NUR3 Q9NUR3 TMEM74B PTHR16125:SF4 TRANSMEMBRANE PROTEIN 74 TRANSMEMBRANE PROTEIN 74B HUMAN|HGNC=12383|UniProtKB=Q53HC9 Q53HC9 EIPR1 PTHR14205:SF15 WD-REPEAT PROTEIN EARP AND GARP COMPLEX-INTERACTING PROTEIN 1 protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein modification by small protein conjugation#GO:0032446;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152 HUMAN|HGNC=10290|UniProtKB=P15927 P15927 RPA2 PTHR13989:SF54 REPLICATION PROTEIN A-RELATED REPLICATION PROTEIN A 32 KDA SUBUNIT DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;telomeric repeat DNA binding#GO:0042162;nucleic acid binding#GO:0003676;binding#GO:0005488;single-stranded DNA binding#GO:0003697 cellular response to stress#GO:0033554;recombinational repair#GO:0000725;double-strand break repair via homologous recombination#GO:0000724;cellular response to stimulus#GO:0051716;DNA replication#GO:0006260;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;response to stimulus#GO:0050896;DNA recombination#GO:0006310;DNA damage response#GO:0006974;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;response to stress#GO:0006950;nucleobase-containing compound metabolic process#GO:0006139;nucleotide-excision repair#GO:0006289 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nuclear replication fork#GO:0043596;membrane-bounded organelle#GO:0043227;site of DNA damage#GO:0090734;intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687;replisome#GO:0030894;replication fork#GO:0005657;chromosome#GO:0005694;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-DNA complex#GO:0032993;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;nucleus#GO:0005634;site of double-strand break#GO:0035861;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;chromosome, telomeric region#GO:0000781;protein-containing complex#GO:0032991 DNA replication#P00017>RPA#P00537 HUMAN|HGNC=14101|UniProtKB=Q9UIV1 Q9UIV1 CNOT7 PTHR10797:SF79 CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 7 hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;RNA nuclease activity#GO:0004540;catalytic activity, acting on RNA#GO:0140098;3'-5' exonuclease activity#GO:0008408;3'-5'-RNA exonuclease activity#GO:0000175;exonuclease activity#GO:0004527;nuclease activity#GO:0004518;hydrolase activity#GO:0016787 cellular process#GO:0009987;positive regulation of biological process#GO:0048518;RNA destabilization#GO:0050779;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;positive regulation of macromolecule metabolic process#GO:0010604;mRNA destabilization#GO:0061157;positive regulation of mRNA metabolic process#GO:1903313;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;regulation of mRNA metabolic process#GO:1903311;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;regulation of mRNA stability#GO:0043488;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;RNA catabolic process#GO:0006401;regulation of biological quality#GO:0065008;RNA metabolic process#GO:0016070;positive regulation of metabolic process#GO:0009893;nucleic acid catabolic process#GO:0141188;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;nucleobase-containing compound catabolic process#GO:0034655;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;positive regulation of catabolic process#GO:0009896;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;macromolecule metabolic process#GO:0043170;positive regulation of mRNA catabolic process#GO:0061014;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA stability#GO:0043487;regulation of RNA metabolic process#GO:0051252 intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;P-body#GO:0000932;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;organelle#GO:0043226;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;CCR4-NOT complex#GO:0030014 RNA metabolism protein#PC00031;RNA processing factor#PC00147;mRNA polyadenylation factor#PC00146 HUMAN|HGNC=13740|UniProtKB=Q9NSN8 Q9NSN8 SNTG1 PTHR10554:SF2 SYNTROPHIN GAMMA-1-SYNTROPHIN cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;dystrophin-associated glycoprotein complex#GO:0016010;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HUMAN|HGNC=2345|UniProtKB=P16220 P16220 CREB1 PTHR45879:SF1 CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN B CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 1 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of DNA-templated transcription#GO:0006355;cell communication#GO:0007154;regulation of RNA metabolic process#GO:0051252;intracellular signal transduction#GO:0035556;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;signaling#GO:0023052;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of nucleobase-containing compound metabolic process#GO:0019219;intracellular signaling cassette#GO:0141124;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;signal transduction#GO:0007165 nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634 basic leucine zipper transcription factor#PC00056;DNA-binding transcription factor#PC00218 Transcription regulation by bZIP transcription factor#P00055>CREB#P01383;Apoptosis signaling pathway#P00006>ATF#P00302;p38 MAPK pathway#P05918>CREB#P06027;Enkephalin release#P05913>CREB#P05971;Gonadotropin-releasing hormone receptor pathway#P06664>CREB#P06749;CCKR signaling map#P06959>CREB1#P07232;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>CREB#P00713;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>CPB#P00702 HUMAN|HGNC=2269|UniProtKB=P10606 P10606 COX5B PTHR10122:SF20 CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL aerobic respiration#GO:0009060;cellular respiration#GO:0045333;energy derivation by oxidation of organic compounds#GO:0015980;ATP synthesis coupled electron transport#GO:0042773;oxidative phosphorylation#GO:0006119;generation of precursor metabolites and energy#GO:0006091;mitochondrial electron transport, cytochrome c to oxygen#GO:0006123;aerobic electron transport chain#GO:0019646;metabolic process#GO:0008152;cellular process#GO:0009987;respiratory electron transport chain#GO:0022904;mitochondrial ATP synthesis coupled electron transport#GO:0042775;electron transport chain#GO:0022900 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;transmembrane transporter complex#GO:1902495;respiratory chain complex IV#GO:0045277;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;cytochrome complex#GO:0070069;organelle envelope#GO:0031967;membrane protein complex#GO:0098796;organelle membrane#GO:0031090;transporter complex#GO:1990351;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial membrane#GO:0031966;respiratory chain complex#GO:0098803;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;mitochondrial inner membrane#GO:0005743;oxidoreductase complex#GO:1990204;membrane#GO:0016020 oxidoreductase#PC00176;oxidase#PC00175 HUMAN|HGNC=19004|UniProtKB=Q6UXS9 Q6UXS9 CASP12 PTHR10454:SF134 CASPASE INACTIVE CASPASE-12 catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;cysteine-type endopeptidase activity#GO:0004197 defense response#GO:0006952;positive regulation of apoptotic process#GO:0043065;positive regulation of response to external stimulus#GO:0032103;positive regulation of defense response#GO:0031349;regulation of apoptotic process#GO:0042981;regulation of response to stimulus#GO:0048583;positive regulation of neuron apoptotic process#GO:0043525;regulation of response to stress#GO:0080134;positive regulation of inflammatory response#GO:0050729;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;regulation of response to external stimulus#GO:0032101;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;regulation of neuron apoptotic process#GO:0043523;response to stress#GO:0006950;inflammatory response#GO:0006954;regulation of defense response#GO:0031347;regulation of inflammatory response#GO:0050727;response to stimulus#GO:0050896;positive regulation of programmed cell death#GO:0043068;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cell death#GO:0008219;apoptotic process#GO:0006915;regulation of programmed cell death#GO:0043067;programmed cell death#GO:0012501 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;canonical inflammasome complex#GO:0061702;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytosol#GO:0005829 protease#PC00190;protein modifying enzyme#PC00260 HUMAN|HGNC=24277|UniProtKB=Q96GY0 Q96GY0 ZC2HC1A PTHR13555:SF25 C2H2 ZINC FINGER CGI-62-RELATED ZINC FINGER C2HC DOMAIN-CONTAINING PROTEIN 1A C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=16685|UniProtKB=Q6P161 Q6P161 MRPL54 PTHR28595:SF1 39S RIBOSOMAL PROTEIN L54, MITOCHONDRIAL LARGE RIBOSOMAL SUBUNIT PROTEIN ML54 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 mitochondrial large ribosomal subunit#GO:0005762;membraneless organelle#GO:0043228;membrane-enclosed lumen#GO:0031974;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;membrane-bounded organelle#GO:0043227;mitochondrial ribosome#GO:0005761;intracellular anatomical structure#GO:0005622;organellar ribosome#GO:0000313;mitochondrion#GO:0005739;ribosome#GO:0005840;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 ribosomal protein#PC00202;translational protein#PC00263 HUMAN|HGNC=20182|UniProtKB=Q9NUM3 Q9NUM3 SLC39A9 PTHR16133:SF5 SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER , MEMBER 9-RELATED ZINC TRANSPORTER ZIP9 secondary carrier transporter#PC00258 HUMAN|HGNC=6193|UniProtKB=P52333 P52333 JAK3 PTHR45807:SF3 TYROSINE-PROTEIN KINASE HOPSCOTCH TYROSINE-PROTEIN KINASE JAK3 non-membrane spanning protein tyrosine kinase activity#GO:0004715;binding#GO:0005488;cytokine receptor binding#GO:0005126;hormone receptor binding#GO:0051427;signaling receptor binding#GO:0005102;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein binding#GO:0005515;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;catalytic activity, acting on a protein#GO:0140096 defense response#GO:0006952;response to external stimulus#GO:0009605;innate immune response#GO:0045087;cellular developmental process#GO:0048869;cell surface receptor signaling pathway via JAK-STAT#GO:0007259;developmental process#GO:0032502;response to peptide hormone#GO:0043434;response to other organism#GO:0051707;biological regulation#GO:0065007;cellular response to nitrogen compound#GO:1901699;immune response#GO:0006955;intracellular signal transduction#GO:0035556;response to nitrogen compound#GO:1901698;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cytokine-mediated signaling pathway#GO:0019221;cellular response to peptide hormone stimulus#GO:0071375;response to external biotic stimulus#GO:0043207;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;interleukin-2-mediated signaling pathway#GO:0038110;interleukin-7-mediated signaling pathway#GO:0038111;cell surface receptor signaling pathway#GO:0007166;regulation of apoptotic process#GO:0042981;cell surface receptor signaling pathway via STAT#GO:0097696;interleukin-9-mediated signaling pathway#GO:0038113;interleukin-15-mediated signaling pathway#GO:0035723;defense response to other organism#GO:0098542;response to chemical#GO:0042221;response to cytokine#GO:0034097;response to type II interferon#GO:0034341;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;defense response to symbiont#GO:0140546;response to hormone#GO:0009725;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;response to peptide#GO:1901652;response to oxygen-containing compound#GO:1901700;immune system process#GO:0002376;cellular response to chemical stimulus#GO:0070887;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;cellular response to hormone stimulus#GO:0032870;cell differentiation#GO:0030154;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;response to endogenous stimulus#GO:0009719;regulation of programmed cell death#GO:0043067 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 non-receptor tyrosine protein kinase#PC00168 Interleukin signaling pathway#P00036>Jak#P00978;JAK/STAT signaling pathway#P00038>Jak#P01034;PDGF signaling pathway#P00047>Jak#P01155 HUMAN|HGNC=19134|UniProtKB=Q8IZP7 Q8IZP7 HS6ST3 PTHR12812:SF3 HEPARAN SULFATE 6-O-SULFOTRANSFERASE 3 HEPARAN-SULFATE 6-O-SULFOTRANSFERASE 3 catalytic activity#GO:0003824;transferase activity#GO:0016740;sulfotransferase activity#GO:0008146;transferase activity, transferring sulphur-containing groups#GO:0016782 biosynthetic process#GO:0009058;proteoglycan biosynthetic process#GO:0030166;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein O-linked glycosylation#GO:0006493;carbohydrate derivative metabolic process#GO:1901135;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;proteoglycan metabolic process#GO:0006029;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100 transferase#PC00220 HUMAN|HGNC=8706|UniProtKB=Q9Y5G5 Q9Y5G5 PCDHGA8 PTHR24028:SF72 CADHERIN-87A PROTOCADHERIN GAMMA-A8 cell adhesion#GO:0007155;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HUMAN|HGNC=28587|UniProtKB=Q8TC76 Q8TC76 FAM110B PTHR14758:SF2 AGAP005440-PA PROTEIN FAM110B HUMAN|HGNC=29209|UniProtKB=Q96A73 Q96A73 KIAA1191 PTHR28342:SF1 MONOOXYGENASE P33MONOX-RELATED MONOOXYGENASE P33MONOX-RELATED cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 oxygenase#PC00177;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=13448|UniProtKB=Q96QD8 Q96QD8 SLC38A2 PTHR22950:SF207 AMINO ACID TRANSPORTER SODIUM-COUPLED NEUTRAL AMINO ACID SYMPORTER 2 L-amino acid transmembrane transporter activity#GO:0015179;amino acid transmembrane transporter activity#GO:0015171;transporter activity#GO:0005215;carboxylic acid transmembrane transporter activity#GO:0046943;transmembrane transporter activity#GO:0022857;neutral L-amino acid transmembrane transporter activity#GO:0015175 L-amino acid transport#GO:0015807;nitrogen compound transport#GO:0071705;cellular process#GO:0009987;carboxylic acid transport#GO:0046942;organic acid transport#GO:0015849;transport#GO:0006810;amino acid transport#GO:0006865;localization#GO:0051179;neutral amino acid transport#GO:0015804;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;amino acid transmembrane transport#GO:0003333 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 amino acid transporter#PC00046;secondary carrier transporter#PC00258 HUMAN|Ensembl=ENSG00000288164.1|UniProtKB=A0AAG2TTP8 A0AAG2TTP8 LOC102723573 PTHR10394:SF40 40S RIBOSOMAL PROTEIN S8 40S RIBOSOMAL PROTEIN S8 ribosomal protein#PC00202;translational protein#PC00263 HUMAN|HGNC=1177|UniProtKB=Q9UHR6 Q9UHR6 ZNHIT2 PTHR15555:SF0 ZINC FINGER HIT DOMAIN CONTAINING PROTEIN 2 PROTEIN FON -RELATED ZINC FINGER HIT DOMAIN-CONTAINING PROTEIN 2 HUMAN|HGNC=32309|UniProtKB=Q8N7F7 Q8N7F7 UBL4B PTHR47905:SF1 UBIQUITIN-LIKE PROTEIN 4B UBIQUITIN-LIKE PROTEIN 4B HUMAN|HGNC=30256|UniProtKB=Q9Y3Y4 Q9Y3Y4 PYGO1 PTHR23194:SF3 PYGOPUS PYGOPUS HOMOLOG 1 transcription coactivator activity#GO:0003713;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 cellular component organization#GO:0016043;regulation of biological process#GO:0050789;gamete generation#GO:0007276;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;cellular process involved in reproduction in multicellular organism#GO:0022412;cell development#GO:0048468;signaling#GO:0023052;spermatid differentiation#GO:0048515;organelle organization#GO:0006996;cellular process#GO:0009987;signal transduction#GO:0007165;cell surface receptor signaling pathway#GO:0007166;cellular component organization or biogenesis#GO:0071840;developmental process involved in reproduction#GO:0003006;germ cell development#GO:0007281;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;Wnt signaling pathway#GO:0016055;reproductive process#GO:0022414;spermatid development#GO:0007286;sexual reproduction#GO:0019953;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;cell communication#GO:0007154;canonical Wnt signaling pathway#GO:0060070;regulation of RNA metabolic process#GO:0051252;multicellular organismal reproductive process#GO:0048609;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;male gamete generation#GO:0048232;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;developmental process#GO:0032502;spermatogenesis#GO:0007283;regulation of biosynthetic process#GO:0009889;nucleus organization#GO:0006997;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468 RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667 Wnt signaling pathway#P00057>Pygo#P01464 HUMAN|HGNC=18282|UniProtKB=Q96KB5 Q96KB5 PBK PTHR43289:SF14 MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED LYMPHOKINE-ACTIVATED KILLER T-CELL-ORIGINATED PROTEIN KINASE protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=7890|UniProtKB=Q9HBY0 Q9HBY0 NOX3 PTHR11972:SF12 NADPH OXIDASE NADPH OXIDASE 3 oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on NAD(P)H#GO:0016651;oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor#GO:0050664;catalytic activity#GO:0003824 defense response#GO:0006952;response to stimulus#GO:0050896;superoxide metabolic process#GO:0006801;cellular process#GO:0009987;response to stress#GO:0006950;reactive oxygen species metabolic process#GO:0072593;metabolic process#GO:0008152 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane protein complex#GO:0098796;membrane#GO:0016020;oxidoreductase complex#GO:1990204;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;catalytic complex#GO:1902494 metabolite interconversion enzyme#PC00262;oxidase#PC00175 HUMAN|HGNC=24983|UniProtKB=A6NNZ2 A6NNZ2 TUBB8B PTHR11588:SF429 TUBULIN TUBULIN BETA 8B-RELATED ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;guanyl nucleotide binding#GO:0019001;nucleoside phosphate binding#GO:1901265;structural constituent of cytoskeleton#GO:0005200;binding#GO:0005488;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;structural molecule activity#GO:0005198;nucleotide binding#GO:0000166;ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168 cell cycle#GO:0007049;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;mitotic cell cycle#GO:0000278;cytoskeleton organization#GO:0007010;cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226;microtubule-based process#GO:0007017 cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;organelle#GO:0043226;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 cytoskeletal protein#PC00085;tubulin#PC00228 Cytoskeletal regulation by Rho GTPase#P00016>tubulin#P00526;Huntington disease#P00029>Microtubule#P00780;Huntington disease#P00029>beta-Tubulin#P00790 HUMAN|HGNC=3025|UniProtKB=P21917 P21917 DRD4 PTHR24247:SF205 5-HYDROXYTRYPTAMINE RECEPTOR D(4) DOPAMINE RECEPTOR neurotransmitter receptor activity#GO:0030594;G protein-coupled amine receptor activity#GO:0008227;transmembrane signaling receptor activity#GO:0004888;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cell-cell signaling#GO:0007267;chemical synaptic transmission#GO:0007268;synaptic signaling#GO:0099536;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154;trans-synaptic signaling#GO:0099537;G protein-coupled receptor signaling pathway#GO:0007186 cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;dendrite#GO:0030425;dendritic tree#GO:0097447 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GoPCR#P00725;Dopamine receptor mediated signaling pathway#P05912>D2/D3/D4#P05965;Nicotine pharmacodynamics pathway#P06587>DRD2/ DRD3/ DRD4#P06603;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711 HUMAN|HGNC=29614|UniProtKB=O75951 O75951 LYZL6 PTHR11407:SF9 LYSOZYME C LYSOZYME-LIKE PROTEIN 6 hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;lysozyme activity#GO:0003796;peptidoglycan muralytic activity#GO:0061783;catalytic activity#GO:0003824;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553 cellular process involved in reproduction in multicellular organism#GO:0022412;fertilization#GO:0009566;reproductive process#GO:0022414;fusion of sperm to egg plasma membrane involved in single fertilization#GO:0007342;cellular process#GO:0009987;single fertilization#GO:0007338;multicellular organismal reproductive process#GO:0048609;sexual reproduction#GO:0019953 secretory vesicle#GO:0099503;cytoplasm#GO:0005737;sperm flagellum#GO:0036126;endomembrane system#GO:0012505;vesicle#GO:0031982;intracellular vesicle#GO:0097708;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;motile cilium#GO:0031514;cellular anatomical structure#GO:0110165;9+2 motile cilium#GO:0097729;cilium#GO:0005929;intracellular organelle#GO:0043229;acrosomal vesicle#GO:0001669;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410 glycosidase#PC00110 HUMAN|HGNC=4539|UniProtKB=Q9GZN0 Q9GZN0 GPR88 PTHR24240:SF234 OPSIN G PROTEIN-COUPLED RECEPTOR 88 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 cellular response to environmental stimulus#GO:0104004;regulation of cellular process#GO:0050794;response to light stimulus#GO:0009416;response to stimulus#GO:0050896;cellular response to radiation#GO:0071478;signaling#GO:0023052;response to abiotic stimulus#GO:0009628;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;biological regulation#GO:0065007;detection of stimulus#GO:0051606;response to radiation#GO:0009314;cellular response to light stimulus#GO:0071482;cellular process#GO:0009987;signal transduction#GO:0007165;cellular response to abiotic stimulus#GO:0071214;response to external stimulus#GO:0009605 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HUMAN|HGNC=13708|UniProtKB=O15218 O15218 ACKR5 PTHR24226:SF0 G-PROTEIN COUPLED RECEPTOR 182 AND ESTROGEN RECEPTOR 1 ATYPICAL CHEMOKINE RECEPTOR 5 molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 vesicle#GO:0031982;cell periphery#GO:0071944;intracellular vesicle#GO:0097708;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410 G-protein coupled receptor#PC00021 HUMAN|HGNC=22990|UniProtKB=Q86Y22 Q86Y22 COL23A1 PTHR24023:SF995 COLLAGEN ALPHA COLLAGEN ALPHA-1(XXIII) CHAIN extracellular matrix structural constituent#GO:0005201;structural molecule activity#GO:0005198 external encapsulating structure organization#GO:0045229;cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;cellular process#GO:0009987;extracellular structure organization#GO:0043062;cellular component organization#GO:0016043 cellular anatomical structure#GO:0110165;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HUMAN|HGNC=29898|UniProtKB=Q9C002 Q9C002 COXFA4L3 PTHR14256:SF3 NADH-UBIQUINONE OXIDOREDUCTASE MLRQ SUBUNIT CYTOCHROME C OXIDASE ASSOCIATED SUBUNIT FA4L3 mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HUMAN|HGNC=24817|UniProtKB=Q9H5N1 Q9H5N1 RABEP2 PTHR31179:SF6 RAB GTPASE-BINDING EFFECTOR PROTEIN RAB GTPASE-BINDING EFFECTOR PROTEIN 2 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=6822|UniProtKB=O60476 O60476 MAN1A2 PTHR11742:SF40 MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE IB hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787 cellular process#GO:0009987;response to stress#GO:0006950;proteasomal protein catabolic process#GO:0010498;response to chemical#GO:0042221;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;catabolic process#GO:0009056;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;response to endoplasmic reticulum stress#GO:0034976;ERAD pathway#GO:0036503;protein metabolic process#GO:0019538 Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane#GO:0016020;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 protein modifying enzyme#PC00260 HUMAN|HGNC=18726|UniProtKB=Q6ZNB6 Q6ZNB6 NFXL1 PTHR12360:SF1 NUCLEAR TRANSCRIPTION FACTOR, X-BOX BINDING 1 NFX1 NF-X1-TYPE ZINC FINGER PROTEIN NFXL1 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 zinc finger transcription factor#PC00244 HUMAN|HGNC=9669|UniProtKB=P23469 P23469 PTPRE PTHR19134:SF499 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE EPSILON catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725;phosphoprotein phosphatase activity#GO:0004721 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154 protein modifying enzyme#PC00260;protein phosphatase#PC00195 HUMAN|HGNC=5287|UniProtKB=P28222 P28222 HTR1B PTHR24247:SF16 5-HYDROXYTRYPTAMINE RECEPTOR 5-HYDROXYTRYPTAMINE RECEPTOR 1B signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;G protein-coupled amine receptor activity#GO:0008227;neurotransmitter receptor activity#GO:0030594 cell-cell signaling#GO:0007267;biological regulation#GO:0065007;synaptic signaling#GO:0099536;cellular process#GO:0009987;signal transduction#GO:0007165;adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway#GO:0007193;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;anterograde trans-synaptic signaling#GO:0098916;signaling#GO:0023052;chemical synaptic transmission#GO:0007268;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cell communication#GO:0007154;trans-synaptic signaling#GO:0099537;G protein-coupled receptor signaling pathway#GO:0007186 membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;dendrite#GO:0030425;dendritic tree#GO:0097447 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 5HT1 type receptor mediated signaling pathway#P04373>5HT1 Receptor#P04404;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GsPCR#P00720;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711 HUMAN|HGNC=23687|UniProtKB=Q5UAW9 Q5UAW9 GPR157 PTHR23112:SF47 G PROTEIN-COUPLED RECEPTOR 157-RELATED G PROTEIN-COUPLED RECEPTOR 157 G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=5469|UniProtKB=P08833 P08833 IGFBP1 PTHR11551:SF6 INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 1 protein binding#GO:0005515;growth factor binding#GO:0019838;binding#GO:0005488 regulation of cell communication#GO:0010646;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cellular process#GO:0050794;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191;protein-binding activity modulator#PC00095 PI3 kinase pathway#P00048>IGFBP1#G01543 HUMAN|HGNC=16441|UniProtKB=Q8TDM5 Q8TDM5 SPACA4 PTHR47613:SF1 SPERM ACROSOME MEMBRANE-ASSOCIATED PROTEIN 4 SPERM ACROSOME MEMBRANE-ASSOCIATED PROTEIN 4 cell-cell recognition#GO:0009988;sexual reproduction#GO:0019953;cell recognition#GO:0008037;sperm-egg recognition#GO:0035036;fertilization#GO:0009566;reproductive process#GO:0022414;cellular process#GO:0009987;single fertilization#GO:0007338 cellular anatomical structure#GO:0110165;membrane#GO:0016020 HUMAN|HGNC=837|UniProtKB=P30049 P30049 ATP5F1D PTHR13822:SF7 ATP SYNTHASE DELTA/EPSILON CHAIN ATP SYNTHASE F(1) COMPLEX SUBUNIT DELTA, MITOCHONDRIAL proton-transporting ATP synthase activity, rotational mechanism#GO:0046933;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;ligase activity#GO:0016874;passive transmembrane transporter activity#GO:0022803;proton transmembrane transporter activity#GO:0015078;catalytic activity#GO:0003824;proton channel activity#GO:0015252;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic cation channel activity#GO:0005261 nucleoside phosphate biosynthetic process#GO:1901293;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;purine ribonucleoside triphosphate biosynthetic process#GO:0009206;carbohydrate derivative metabolic process#GO:1901135;purine ribonucleoside triphosphate metabolic process#GO:0009205;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;nucleoside triphosphate biosynthetic process#GO:0009142;organophosphate biosynthetic process#GO:0090407;proton motive force-driven ATP synthesis#GO:0015986;nucleoside phosphate metabolic process#GO:0006753;nucleoside triphosphate metabolic process#GO:0009141;purine nucleoside triphosphate biosynthetic process#GO:0009145;purine nucleoside triphosphate metabolic process#GO:0009144;primary metabolic process#GO:0044238;nucleobase-containing small molecule metabolic process#GO:0055086;ribonucleoside triphosphate biosynthetic process#GO:0009201;carbohydrate derivative biosynthetic process#GO:1901137;ATP biosynthetic process#GO:0006754;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;ATP metabolic process#GO:0046034;ribose phosphate biosynthetic process#GO:0046390;nucleotide biosynthetic process#GO:0009165;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;ribonucleotide metabolic process#GO:0009259;small molecule metabolic process#GO:0044281;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;phosphorus metabolic process#GO:0006793 transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;proton-transporting two-sector ATPase complex#GO:0016469;catalytic complex#GO:1902494;cation channel complex#GO:0034703;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;proton-transporting ATP synthase complex#GO:0045259;membrane#GO:0016020;membrane protein complex#GO:0098796;respiratory chain complex#GO:0098803 ATP synthase#PC00002 HUMAN|HGNC=3591|UniProtKB=Q9Y4F1 Q9Y4F1 FARP1 PTHR45858:SF2 FERM DOMAIN CONTAINING PROTEIN FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 1 molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;guanyl-nucleotide exchange factor activity#GO:0005085 HUMAN|HGNC=26736|UniProtKB=Q5U5R9 Q5U5R9 HECTD2 PTHR45622:SF56 UBIQUITIN-PROTEIN LIGASE E3A-RELATED E3 UBIQUITIN-PROTEIN LIGASE HECTD2-RELATED ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 ubiquitin-protein ligase#PC00234 Ubiquitin proteasome pathway#P00060>E3#P01490 HUMAN|HGNC=14509|UniProtKB=Q9Y3D9 Q9Y3D9 MRPS23 PTHR15925:SF2 MITOCHONDRIAL RIBOSOMAL PROTEIN S23 SMALL RIBOSOMAL SUBUNIT PROTEIN MS23 mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 translational protein#PC00263;ribosomal protein#PC00202 HUMAN|HGNC=14357|UniProtKB=Q8N119 Q8N119 MMP21 PTHR10201:SF340 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE-21 catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;metalloendopeptidase activity#GO:0004222 cellular component organization#GO:0016043;cellular process#GO:0009987;catabolic process#GO:0009056;extracellular structure organization#GO:0043062;metabolic process#GO:0008152;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;external encapsulating structure organization#GO:0045229 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 Alzheimer disease-presenilin pathway#P00004>Matrix metalloprotease#P00130 HUMAN|HGNC=30246|UniProtKB=Q9NP64 Q9NP64 ZCCHC17 PTHR15838:SF1 NUCLEOLAR PROTEIN OF 40 KDA ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 17 nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of RNA metabolic process#GO:0051253;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;negative regulation of RNA catabolic process#GO:1902369;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA stability#GO:0043487;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;regulation of biological quality#GO:0065008;negative regulation of catabolic process#GO:0009895;RNA stabilization#GO:0043489 HUMAN|HGNC=6834|UniProtKB=P27338 P27338 MAOB PTHR43563:SF24 AMINE OXIDASE AMINE OXIDASE [FLAVIN-CONTAINING] B catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 serotonin metabolic process#GO:0042428;amine catabolic process#GO:0009310;metabolic process#GO:0008152;biogenic amine metabolic process#GO:0006576;catabolic process#GO:0009056;phenol-containing compound metabolic process#GO:0018958;cellular process#GO:0009987;indole-containing compound metabolic process#GO:0042430;amine metabolic process#GO:0009308 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 oxidase#PC00175;oxidoreductase#PC00176 5-Hydroxytryptamine degredation#P04372>Monoamine Oxidase#P04401;Adrenaline and noradrenaline biosynthesis#P00001>MAO#P00067;Dopamine receptor mediated signaling pathway#P05912>MAO#P05963 HUMAN|HGNC=26921|UniProtKB=Q2NL67 Q2NL67 PARP6 PTHR21328:SF23 POLY ADP-RIBOSE POLYMERASE FAMILY, MEMBER PARP PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP6 catalytic activity#GO:0003824;protein kinase activator activity#GO:0030295;glycosyltransferase activity#GO:0016757;molecular function regulator activity#GO:0098772;kinase activator activity#GO:0019209;pentosyltransferase activity#GO:0016763;protein serine/threonine kinase activator activity#GO:0043539;enzyme activator activity#GO:0008047;transferase activity#GO:0016740;kinase regulator activity#GO:0019207;protein kinase regulator activity#GO:0019887;NAD+ poly-ADP-ribosyltransferase activity#GO:0003950;kinase binding#GO:0019900;binding#GO:0005488;enzyme binding#GO:0019899;protein binding#GO:0005515;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677 endoplasmic reticulum unfolded protein response#GO:0030968;response to stress#GO:0006950;cellular process#GO:0009987;signal transduction#GO:0007165;biological regulation#GO:0065007;response to endoplasmic reticulum stress#GO:0034976;cellular response to unfolded protein#GO:0034620;cellular response to topologically incorrect protein#GO:0035967;cellular response to stress#GO:0033554;response to unfolded protein#GO:0006986;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;response to topologically incorrect protein#GO:0035966;signaling#GO:0023052 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;organelle envelope#GO:0031967;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;cytoplasm#GO:0005737;nuclear envelope#GO:0005635;endomembrane system#GO:0012505;nucleus#GO:0005634;endoplasmic reticulum tubular network#GO:0071782;membrane#GO:0016020;endoplasmic reticulum#GO:0005783 HUMAN|HGNC=28559|UniProtKB=Q5VVX9 Q5VVX9 UBE2U PTHR24067:SF252 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2 U transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin conjugating enzyme activity#GO:0061631;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-like protein conjugating enzyme activity#GO:0061650;ubiquitin-protein transferase activity#GO:0004842 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;protein modification process#GO:0036211;modification-dependent protein catabolic process#GO:0019941;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;catabolic process#GO:0009056;protein modification by small protein conjugation or removal#GO:0070647;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;modification-dependent macromolecule catabolic process#GO:0043632;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;response to stress#GO:0006950;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;protein ubiquitination#GO:0016567;proteasomal protein catabolic process#GO:0010498;post-translational protein modification#GO:0043687;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=29378|UniProtKB=Q96FC7 Q96FC7 PHYHIPL PTHR15698:SF8 PROTEIN CBG15099 PHYTANOYL-COA HYDROXYLASE-INTERACTING PROTEIN-LIKE cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=2664|UniProtKB=P61803 P61803 DAD1 PTHR10705:SF0 DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1 DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1 glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487;glycoprotein biosynthetic process#GO:0009101;biosynthetic process#GO:0009058 endoplasmic reticulum protein-containing complex#GO:0140534;organelle membrane#GO:0031090;transferase complex#GO:1990234;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;membrane#GO:0016020;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;endoplasmic reticulum subcompartment#GO:0098827;oligosaccharyltransferase complex#GO:0008250;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane protein complex#GO:0098796 glycosyltransferase#PC00111;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=28180|UniProtKB=Q9BRR3 Q9BRR3 PGAP4 PTHR31410:SF1 TRANSMEMBRANE PROTEIN 246 GPI-N-ACETYLGALACTOSAMINE TRANSFERASE PGAP4 transferase activity#GO:0016740;catalytic activity#GO:0003824;glycosyltransferase activity#GO:0016757 GPI anchor metabolic process#GO:0006505;glycerophospholipid biosynthetic process#GO:0046474;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;organophosphate metabolic process#GO:0019637;biosynthetic process#GO:0009058;GPI anchor biosynthetic process#GO:0006506;glycerophospholipid metabolic process#GO:0006650;lipid biosynthetic process#GO:0008610;protein maturation#GO:0051604;gene expression#GO:0010467;glycolipid biosynthetic process#GO:0009247;organophosphate biosynthetic process#GO:0090407;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phospholipid metabolic process#GO:0006644;glycerolipid metabolic process#GO:0046486;liposaccharide metabolic process#GO:1903509;GPI anchored protein biosynthesis#GO:0180046;glycolipid metabolic process#GO:0006664;phospholipid biosynthetic process#GO:0008654 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020 HUMAN|HGNC=30377|UniProtKB=Q14160 Q14160 SCRIB PTHR23119:SF57 DISCS LARGE PROTEIN SCRIBBLE HOMOLOG molecular adaptor activity#GO:0060090;protein binding#GO:0005515;signaling adaptor activity#GO:0035591;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;protein-macromolecule adaptor activity#GO:0030674;kinase binding#GO:0019900;binding#GO:0005488 macromolecule localization#GO:0033036;endosome to plasma membrane protein transport#GO:0099638;cell migration#GO:0016477;biological regulation#GO:0065007;regulation of postsynaptic membrane neurotransmitter receptor levels#GO:0099072;intracellular transport#GO:0046907;transport#GO:0006810;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;vesicle-mediated transport to the plasma membrane#GO:0098876;protein localization to plasma membrane#GO:0072659;cell motility#GO:0048870;establishment or maintenance of apical/basal cell polarity#GO:0035088;protein localization to cell junction#GO:1902414;establishment or maintenance of bipolar cell polarity#GO:0061245;establishment of protein localization to plasma membrane#GO:0061951;localization within membrane#GO:0051668;establishment or maintenance of epithelial cell apical/basal polarity#GO:0045197;localization#GO:0051179;cell-cell adhesion#GO:0098609;establishment of protein localization to membrane#GO:0090150;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;vesicle-mediated transport#GO:0016192;protein localization to cell periphery#GO:1990778;intracellular protein transport#GO:0006886;protein localization to synapse#GO:0035418;neurotransmitter receptor transport to postsynaptic membrane#GO:0098969;endosomal transport#GO:0016197;protein localization to membrane#GO:0072657;endocytic recycling#GO:0032456;establishment or maintenance of cell polarity#GO:0007163;cell adhesion#GO:0007155;receptor clustering#GO:0043113;cellular localization#GO:0051641;regulation of biological quality#GO:0065008;protein transport#GO:0015031 organelle#GO:0043226;asymmetric synapse#GO:0032279;cellular anatomical structure#GO:0110165;synapse#GO:0045202;basal part of cell#GO:0045178;postsynapse#GO:0098794;anchoring junction#GO:0070161;postsynaptic density#GO:0014069;postsynaptic membrane#GO:0045211;plasma membrane#GO:0005886;plasma membrane region#GO:0098590;postsynaptic specialization#GO:0099572;neuron to neuron synapse#GO:0098984;basal plasma membrane#GO:0009925;cell periphery#GO:0071944;basolateral plasma membrane#GO:0016323;membrane#GO:0016020;cell-cell junction#GO:0005911;adherens junction#GO:0005912;cell junction#GO:0030054;synaptic membrane#GO:0097060 scaffold/adaptor protein#PC00226 HUMAN|HGNC=13557|UniProtKB=Q9BYF1 Q9BYF1 ACE2 PTHR10514:SF24 ANGIOTENSIN-CONVERTING ENZYME ANGIOTENSIN-CONVERTING ENZYME 2 metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096 regulation of biological quality#GO:0065008;protein metabolic process#GO:0019538;signaling receptor ligand precursor processing#GO:0140448;circulatory system process#GO:0003013;proteolysis#GO:0006508;regulation of hormone levels#GO:0010817;primary metabolic process#GO:0044238;system process#GO:0003008;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;biological regulation#GO:0065007;biosynthetic process#GO:0009058;protein maturation#GO:0051604;multicellular organismal process#GO:0032501;gene expression#GO:0010467;blood circulation#GO:0008015;hormone metabolic process#GO:0042445;cellular process#GO:0009987;protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059;peptide hormone processing#GO:0016486;regulation of systemic arterial blood pressure#GO:0003073;regulation of blood pressure#GO:0008217 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;extracellular region#GO:0005576;cell periphery#GO:0071944 protease#PC00190;protein modifying enzyme#PC00260;metalloprotease#PC00153 HUMAN|HGNC=32324|UniProtKB=Q6ZSA7 Q6ZSA7 LRRC55 PTHR46473:SF5 GH08155P LEUCINE-RICH REPEAT-CONTAINING PROTEIN 55 monoatomic cation channel activity#GO:0005261;molecular function regulator activity#GO:0098772;ion channel regulator activity#GO:0099106;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;potassium ion transmembrane transporter activity#GO:0015079;channel regulator activity#GO:0016247;channel activity#GO:0015267;transmembrane transporter binding#GO:0044325;potassium channel activity#GO:0005267;transporter regulator activity#GO:0141108;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;transporter activity#GO:0005215;voltage-gated channel activity#GO:0022832;protein binding#GO:0005515;molecular function activator activity#GO:0140677;monoatomic cation transmembrane transporter activity#GO:0008324;binding#GO:0005488;voltage-gated monoatomic ion channel activity#GO:0005244;potassium channel regulator activity#GO:0015459;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836 cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703 HUMAN|HGNC=12981|UniProtKB=P17023 P17023 ZNF19 PTHR24381:SF59 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 19 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=8707|UniProtKB=Q9Y5G4 Q9Y5G4 PCDHGA9 PTHR24028:SF86 CADHERIN-87A PROTOCADHERIN GAMMA-A9 cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 cell adhesion molecule#PC00069;cadherin#PC00057 HUMAN|HGNC=5662|UniProtKB=A0A0B4J1U7 A0A0B4J1U7 IGHV6-1 PTHR23266:SF323 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 4-30-2-RELATED antigen binding#GO:0003823;binding#GO:0005488 response to stimulus#GO:0050896;adaptive immune response#GO:0002250;immune response#GO:0006955;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449;immunoglobulin mediated immune response#GO:0016064;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immune system process#GO:0002376;immune effector process#GO:0002252 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=24546|UniProtKB=Q96F85 Q96F85 CNRIP1 PTHR31952:SF1 CB1 CANNABINOID RECEPTOR-INTERACTING PROTEIN 1 CB1 CANNABINOID RECEPTOR-INTERACTING PROTEIN 1 protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102;G protein-coupled receptor binding#GO:0001664 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HUMAN|HGNC=9201|UniProtKB=P01189 P01189 POMC PTHR11416:SF7 PRO-OPIOMELANOCORTIN PRO-OPIOMELANOCORTIN signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;hormone activity#GO:0005179;molecular function activator activity#GO:0140677 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;cell-cell signaling#GO:0007267;cellular pigmentation#GO:0033059;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;pigmentation#GO:0043473 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 Cortocotropin releasing factor receptor signaling pathway#P04380>ACTH#P04453;Opioid proopiomelanocortin pathway#P05917>ACTH#P06008;Cortocotropin releasing factor receptor signaling pathway#P04380>proopiomelanocortin#G04671;Cortocotropin releasing factor receptor signaling pathway#P04380>beta-endorphin#P04455;Opioid proopiomelanocortin pathway#P05917>alpha-MSH#P06007;Opioid proopiomelanocortin pathway#P05917>beta-Endorphin#P06006;Opioid proopiomelanocortin pathway#P05917>proopiomelanocortin#P06010;Cortocotropin releasing factor receptor signaling pathway#P04380>proopiomelanocortin#P04452 HUMAN|HGNC=17734|UniProtKB=Q96RJ0 Q96RJ0 TAAR1 PTHR24249:SF415 HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR TRACE AMINE-ASSOCIATED RECEPTOR 1 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089 signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HUMAN|HGNC=14758|UniProtKB=Q8NH08 Q8NH08 OR10AC1 PTHR26453:SF638 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 10AC1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 nervous system process#GO:0050877;sensory perception#GO:0007600;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;system process#GO:0003008;detection of chemical stimulus#GO:0009593;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;response to chemical#GO:0042221;response to stimulus#GO:0050896 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=21096|UniProtKB=Q9NXC2 Q9NXC2 GFOD1 PTHR43818:SF2 BCDNA.GH03377 GLUCOSE-FRUCTOSE OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 1 external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 dehydrogenase#PC00092 HUMAN|HGNC=12771|UniProtKB=O95389 O95389 CCN6 PTHR11348:SF3 CONNECTIVE TISSUE GROWTH FACTOR-RELATED CELLULAR COMMUNICATION NETWORK FACTOR 6 binding#GO:0005488;signaling receptor binding#GO:0005102;glycosaminoglycan binding#GO:0005539;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;carbohydrate derivative binding#GO:0097367;heparin binding#GO:0008201;cell adhesion molecule binding#GO:0050839;integrin binding#GO:0005178 positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;positive regulation of developmental process#GO:0051094;positive regulation of cell differentiation#GO:0045597;regulation of cell differentiation#GO:0045595;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of developmental process#GO:0050793;signaling#GO:0023052;cell adhesion#GO:0007155;cell communication#GO:0007154 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 growth factor#PC00112;intercellular signal molecule#PC00207 HUMAN|HGNC=13388|UniProtKB=Q00994 Q00994 BEX3 PTHR19430:SF1 PROTEIN BEX1-RELATED PROTEIN BEX3 signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell communication#GO:0007154 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 HUMAN|HGNC=25827|UniProtKB=Q6PF04 Q6PF04 ZNF613 PTHR24404:SF124 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 613 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218 HUMAN|HGNC=15248|UniProtKB=Q8NH76 Q8NH76 OR56B4 PTHR26450:SF142 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 56B4 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=28735|UniProtKB=Q8IXM7 Q8IXM7 CIMAP1C PTHR21580:SF3 SHIPPO-1-RELATED CILIARY MICROTUBULE ASSOCIATED PROTEIN 1C developmental process involved in reproduction#GO:0003006;germ cell development#GO:0007281;gamete generation#GO:0007276;cell differentiation#GO:0030154;reproductive process#GO:0022414;cellular process involved in reproduction in multicellular organism#GO:0022412;cell development#GO:0048468;spermatid differentiation#GO:0048515;spermatid development#GO:0007286;sexual reproduction#GO:0019953;anatomical structure development#GO:0048856;multicellular organismal reproductive process#GO:0048609;cellular process#GO:0009987;male gamete generation#GO:0048232;developmental process#GO:0032502;spermatogenesis#GO:0007283;cellular developmental process#GO:0048869 cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;supramolecular complex#GO:0099080;organelle#GO:0043226;cytoplasmic microtubule#GO:0005881;microtubule cytoskeleton#GO:0015630;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;microtubule#GO:0005874;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 structural protein#PC00211 HUMAN|HGNC=15853|UniProtKB=Q9Y6D5 Q9Y6D5 ARFGEF2 PTHR10663:SF124 GUANYL-NUCLEOTIDE EXCHANGE FACTOR BREFELDIN A-INHIBITED GUANINE NUCLEOTIDE-EXCHANGE PROTEIN 2 Golgi to plasma membrane transport#GO:0006893;cellular component organization#GO:0016043;post-Golgi vesicle-mediated transport#GO:0006892;cellular localization#GO:0051641;localization#GO:0051179;localization within membrane#GO:0051668;endomembrane system organization#GO:0010256;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;organelle organization#GO:0006996;vesicle organization#GO:0016050;endosome organization#GO:0007032;vesicle-mediated transport to the plasma membrane#GO:0098876;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;Golgi vesicle transport#GO:0048193;transport#GO:0006810 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;Golgi apparatus subcompartment#GO:0098791;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=8775|UniProtKB=Q01064 Q01064 PDE1B PTHR11347:SF194 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE DUAL SPECIFICITY CALCIUM_CALMODULIN-DEPENDENT 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 1B cyclic-nucleotide phosphodiesterase activity#GO:0004112;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;phosphoric diester hydrolase activity#GO:0008081;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;regulation of cell communication#GO:0010646;negative regulation of response to stimulus#GO:0048585;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;negative regulation of signaling#GO:0023057;negative regulation of cellular process#GO:0048523;regulation of intracellular signal transduction#GO:1902531 somatodendritic compartment#GO:0036477;neuronal cell body#GO:0043025;cellular anatomical structure#GO:0110165;cell body#GO:0044297 phosphodiesterase#PC00185;hydrolase#PC00121 HUMAN|HGNC=32179|UniProtKB=A6NLW8 A6NLW8 DUXA PTHR46123:SF15 MIX-TYPE HOMEOBOX GENE 1-RELATED DOUBLE HOMEOBOX PROTEIN A sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=2536|UniProtKB=P43235 P43235 CTSK PTHR12411:SF1048 CYSTEINE PROTEASE FAMILY C1-RELATED CATHEPSIN K peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;cysteine-type endopeptidase activity#GO:0004197;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824 catabolic process#GO:0009056;cellular process#GO:0009987;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057 extracellular region#GO:0005576;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;vacuole#GO:0005773 cysteine protease#PC00081;protein modifying enzyme#PC00260;protease#PC00190 HUMAN|HGNC=28100|UniProtKB=Q8N4V1 Q8N4V1 MMGT1 PTHR21181:SF7 ER membrane protein complex subunit 5-related ER MEMBRANE PROTEIN COMPLEX SUBUNIT 5 molecular carrier activity#GO:0140104;membrane insertase activity#GO:0032977;protein carrier activity#GO:0140597 establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;intracellular protein localization#GO:0008104;establishment of protein localization to membrane#GO:0090150;macromolecule localization#GO:0033036;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of protein localization#GO:0045184;tail-anchored membrane protein insertion into ER membrane#GO:0071816;protein insertion into membrane#GO:0051205;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;localization within membrane#GO:0051668;cellular localization#GO:0051641;localization#GO:0051179;cellular component organization#GO:0016043;protein insertion into ER membrane#GO:0045048;endoplasmic reticulum organization#GO:0007029;protein localization to organelle#GO:0033365 protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasm#GO:0005737;membrane#GO:0016020;endoplasmic reticulum protein-containing complex#GO:0140534;organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;EMC complex#GO:0072546;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827 HUMAN|HGNC=7931|UniProtKB=O75607 O75607 NPM3 PTHR22747:SF13 NUCLEOPLASMIN NUCLEOPLASMIN-3 RNA binding#GO:0003723;protein binding#GO:0005515;chromatin binding#GO:0003682;histone binding#GO:0042393;nucleic acid binding#GO:0003676;binding#GO:0005488 chromatin remodeling#GO:0006338;chromatin organization#GO:0006325;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043 membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228;organelle lumen#GO:0043233;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 chaperone#PC00072 HUMAN|HGNC=32926|UniProtKB=Q08ET2 Q08ET2 SIGLEC14 PTHR12035:SF109 SIALIC ACID BINDING IMMUNOGLOBULIN-LIKE LECTIN SIALIC ACID-BINDING IG-LIKE LECTIN 14 organic acid binding#GO:0043177;binding#GO:0005488;anion binding#GO:0043168;small molecule binding#GO:0036094;carboxylic acid binding#GO:0031406;ion binding#GO:0043167;carbohydrate derivative binding#GO:0097367 cellular process#GO:0009987;cell adhesion#GO:0007155 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 cell adhesion molecule#PC00069;immunoglobulin superfamily cell adhesion molecule#PC00125 HUMAN|HGNC=8957|UniProtKB=P37287 P37287 PIGA PTHR45871:SF3 N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A acetylglucosaminyltransferase activity#GO:0008375;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;catalytic activity#GO:0003824 primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;phospholipid metabolic process#GO:0006644;glycolipid metabolic process#GO:0006664;phospholipid biosynthetic process#GO:0008654;GPI anchored protein biosynthesis#GO:0180046;glycerolipid metabolic process#GO:0046486;liposaccharide metabolic process#GO:1903509;organophosphate biosynthetic process#GO:0090407;protein metabolic process#GO:0019538;glycolipid biosynthetic process#GO:0009247;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;carbohydrate derivative metabolic process#GO:1901135;organophosphate metabolic process#GO:0019637;biosynthetic process#GO:0009058;protein maturation#GO:0051604;lipid biosynthetic process#GO:0008610;gene expression#GO:0010467;glycerophospholipid metabolic process#GO:0006650;GPI anchor biosynthetic process#GO:0006506;lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474;GPI anchor metabolic process#GO:0006505;metabolic process#GO:0008152;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170 organelle membrane#GO:0031090;endoplasmic reticulum protein-containing complex#GO:0140534;endoplasmic reticulum#GO:0005783;transferase complex#GO:1990234;endoplasmic reticulum membrane#GO:0005789;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;catalytic complex#GO:1902494;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane protein complex#GO:0098796 HUMAN|HGNC=4117|UniProtKB=Q00973 Q00973 B4GALNT1 PTHR15046:SF1 GLYCO_TRANS_2-LIKE DOMAIN-CONTAINING PROTEIN BETA-1,4 N-ACETYLGALACTOSAMINYLTRANSFERASE 1 acetylgalactosaminyltransferase activity#GO:0008376;glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194;hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;catalytic activity#GO:0003824 ceramide metabolic process#GO:0006672;glycolipid biosynthetic process#GO:0009247;glycosphingolipid biosynthetic process#GO:0006688;glycolipid metabolic process#GO:0006664;liposaccharide metabolic process#GO:1903509;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;lipid metabolic process#GO:0006629;ceramide biosynthetic process#GO:0046513;sphingolipid biosynthetic process#GO:0030148;metabolic process#GO:0008152;sphingolipid metabolic process#GO:0006665;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135 HUMAN|HGNC=8808|UniProtKB=P11177 P11177 PDHB PTHR11624:SF116 DEHYDROGENASE RELATED PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT BETA, MITOCHONDRIAL catalytic activity#GO:0003824;oxidoreductase activity, acting on the aldehyde or oxo group of donors#GO:0016903;oxidoreductase activity#GO:0016491 pyruvate metabolic process#GO:0006090;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;purine-containing compound metabolic process#GO:0072521;monocarboxylic acid metabolic process#GO:0032787;phosphorus metabolic process#GO:0006793;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;aerobic respiration#GO:0009060;cellular respiration#GO:0045333;organophosphate biosynthetic process#GO:0090407;oxoacid metabolic process#GO:0043436;purine-containing compound biosynthetic process#GO:0072522;acetyl-CoA metabolic process#GO:0006084;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;sulfur compound metabolic process#GO:0006790;nucleobase-containing small molecule metabolic process#GO:0055086;acyl-CoA metabolic process#GO:0006637;nucleoside phosphate biosynthetic process#GO:1901293;energy derivation by oxidation of organic compounds#GO:0015980;generation of precursor metabolites and energy#GO:0006091;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654 transferase complex#GO:1990234;catalytic complex#GO:1902494;oxidoreductase complex#GO:1990204;acetyltransferase complex#GO:1902493;protein-containing complex#GO:0032991 oxidoreductase#PC00176;dehydrogenase#PC00092 HUMAN|HGNC=23338|UniProtKB=Q5T8D3 Q5T8D3 ACBD5 PTHR23310:SF6 ACYL-COA-BINDING PROTEIN, ACBP ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5 heterocyclic compound binding#GO:1901363;lipid binding#GO:0008289;ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;anion binding#GO:0043168;small molecule binding#GO:0036094 small molecule metabolic process#GO:0044281;cellular process#GO:0009987;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;lipid metabolic process#GO:0006629;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microbody#GO:0042579;peroxisome#GO:0005777;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 transfer/carrier protein#PC00219 HUMAN|HGNC=5651|UniProtKB=P01824 P01824 IGHV4-39 PTHR23266:SF323 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 4-30-2-RELATED binding#GO:0005488;antigen binding#GO:0003823 immune system process#GO:0002376;immune effector process#GO:0002252;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449;immunoglobulin mediated immune response#GO:0016064;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immune response#GO:0006955;response to stimulus#GO:0050896;adaptive immune response#GO:0002250 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=32003|UniProtKB=Q5VYP0 Q5VYP0 SPATA31A3 PTHR21859:SF55 ACROSOME-SPECIFIC PROTEIN SPERMATOGENESIS-ASSOCIATED PROTEIN 31A1-RELATED HUMAN|HGNC=1449|UniProtKB=P0DP25 P0DP25 CALM3 PTHR23050:SF427 CALCIUM BINDING PROTEIN CALMODULIN-3 molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;protein kinase regulator activity#GO:0019887;protein serine/threonine kinase activator activity#GO:0043539;enzyme activator activity#GO:0008047;protein kinase activator activity#GO:0030295;metal ion binding#GO:0046872;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;cation binding#GO:0043169;ion binding#GO:0043167;kinase activator activity#GO:0019209;binding#GO:0005488;small molecule binding#GO:0036094;calcium ion binding#GO:0005509 intracellular signal transduction#GO:0035556;response to calcium ion#GO:0051592;cell communication#GO:0007154;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;detection of chemical stimulus#GO:0009593;calcineurin-mediated signaling#GO:0097720;regulation of transmembrane transport#GO:0034762;signaling#GO:0023052;regulation of metal ion transport#GO:0010959;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;response to metal ion#GO:0010038;regulation of monoatomic cation transmembrane transport#GO:1904062;regulation of transport#GO:0051049;regulation of localization#GO:0032879;regulation of release of sequestered calcium ion into cytosol#GO:0051279;calcium-mediated signaling#GO:0019722;signal transduction#GO:0007165;regulation of monoatomic ion transmembrane transport#GO:0034765;cellular process#GO:0009987;detection of stimulus#GO:0051606;biological regulation#GO:0065007;regulation of calcium ion transport#GO:0051924;intracellular signaling cassette#GO:0141124;regulation of monoatomic ion transport#GO:0043269;response to chemical#GO:0042221 membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;microtubule organizing center#GO:0005815;centrosome#GO:0005813;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;myelin sheath#GO:0043209;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;microtubule cytoskeleton#GO:0015630;nucleus#GO:0005634 calcium-binding protein#PC00060;calmodulin-related#PC00061 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Calmodulin#P00755;B cell activation#P00010>Calmodulin#P00375;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Phosphorylase b kinase#P00716;T cell activation#P00053>Calmodulin#P01305 HUMAN|HGNC=24822|UniProtKB=Q9H479 Q9H479 FN3K PTHR12149:SF9 FRUCTOSAMINE 3 KINASE-RELATED PROTEIN FRUCTOSAMINE-3-KINASE kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 protein modification process#GO:0036211;primary metabolic process#GO:0044238;cellular process#GO:0009987;protein repair#GO:0030091;metabolic process#GO:0008152;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 kinase#PC00137;metabolite interconversion enzyme#PC00262;transferase#PC00220 HUMAN|HGNC=30361|UniProtKB=Q9BUL9 Q9BUL9 RPP25 PTHR13516:SF5 RIBONUCLEASE P SUBUNIT P25 RIBONUCLEASE P PROTEIN SUBUNIT P25 binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187 ribonuclease MRP complex#GO:0000172;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;ribonucleoprotein complex#GO:1990904;endonuclease complex#GO:1905348;endoribonuclease complex#GO:1902555;intracellular protein-containing complex#GO:0140535;sno(s)RNA-containing ribonucleoprotein complex#GO:0005732 RNA metabolism protein#PC00031;endoribonuclease#PC00094 HUMAN|HGNC=10690|UniProtKB=O95810 O95810 CAVIN2 PTHR15240:SF1 CAVIN CAVEOLAE-ASSOCIATED PROTEIN 2 enzyme binding#GO:0019899;protein kinase binding#GO:0019901;kinase binding#GO:0019900;binding#GO:0005488;protein binding#GO:0005515 membrane#GO:0016020;membrane raft#GO:0045121;caveola#GO:0005901;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;cytoplasm#GO:0005737;plasma membrane#GO:0005886;membrane microdomain#GO:0098857;plasma membrane raft#GO:0044853;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HUMAN|HGNC=34342|UniProtKB=A6NHR8 A6NHR8 FAM47DP PTHR47415:SF2 PROTEIN FAM47B PROTEIN FAM47C-RELATED HUMAN|HGNC=17911|UniProtKB=Q13686 Q13686 ALKBH1 PTHR16557:SF12 ALKYLATED DNA REPAIR PROTEIN ALKB-RELATED NUCLEIC ACID DIOXYGENASE ALKBH1 dioxygenase activity#GO:0051213;cation binding#GO:0043169;ion binding#GO:0043167;small molecule binding#GO:0036094;transition metal ion binding#GO:0046914;oxidoreductase activity#GO:0016491;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;metal ion binding#GO:0046872;binding#GO:0005488;catalytic activity, acting on DNA#GO:0140097;demethylase activity#GO:0032451;iron ion binding#GO:0005506;catalytic activity, acting on RNA#GO:0140098;ferrous iron binding#GO:0008198 RNA modification#GO:0009451;metabolic process#GO:0008152;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound metabolic process#GO:0006139 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA metabolism protein#PC00009 HUMAN|HGNC=12953|UniProtKB=P49910 P49910 ZNF165 PTHR23226:SF61 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER PROTEIN 165 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=18585|UniProtKB=Q96DH6 Q96DH6 MSI2 PTHR48032:SF10 RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6 RNA-BINDING PROTEIN MUSASHI HOMOLOG 2 RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676 regulation of protein metabolic process#GO:0051246;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;post-transcriptional regulation of gene expression#GO:0010608;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=2069|UniProtKB=P49760 P49760 CLK2 PTHR45646:SF6 SERINE/THREONINE-PROTEIN KINASE DOA-RELATED DUAL SPECIFICITY PROTEIN KINASE CLK2 phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA splicing#GO:0043484;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=7406|UniProtKB=P02795 P02795 MT2A PTHR23299:SF60 METALLOTHIONEIN METALLOTHIONEIN-2 metal ion binding#GO:0046872;cation binding#GO:0043169;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 intracellular monoatomic ion homeostasis#GO:0006873;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;response to toxic substance#GO:0009636;homeostatic process#GO:0042592;cellular response to chemical stimulus#GO:0070887;inorganic ion homeostasis#GO:0098771;response to stress#GO:0006950;detoxification of inorganic compound#GO:0061687;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;response to chemical#GO:0042221;detoxification#GO:0098754;response to cadmium ion#GO:0046686;response to metal ion#GO:0010038;chemical homeostasis#GO:0048878;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 defense/immunity protein#PC00090 HUMAN|HGNC=12450|UniProtKB=P17643 P17643 TYRP1 PTHR11474:SF3 TYROSINASE FAMILY MEMBER 5,6-DIHYDROXYINDOLE-2-CARBOXYLIC ACID OXIDASE oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824;monooxygenase activity#GO:0004497 cellular pigmentation#GO:0033059;cell differentiation#GO:0030154;cellular process#GO:0009987;developmental pigmentation#GO:0048066;melanocyte differentiation#GO:0030318;cellular component organization#GO:0016043;organelle organization#GO:0006996;vesicle organization#GO:0016050;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;developmental process#GO:0032502;melanosome organization#GO:0032438;pigmentation#GO:0043473 intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;melanosome#GO:0042470;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular vesicle#GO:0097708 oxygenase#PC00177 HUMAN|HGNC=25112|UniProtKB=Q96IR2 Q96IR2 ZNF845 PTHR24376:SF74 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 845 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=3809|UniProtKB=Q12946 Q12946 FOXF1 PTHR46262:SF1 FORKHEAD BOX PROTEIN BINIOU FORKHEAD BOX PROTEIN F1 nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 animal organ development#GO:0048513;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;developmental process#GO:0032502;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;animal gross anatomical part developmental process#GO:0160108;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;animal organ morphogenesis#GO:0009887;regulation of cellular process#GO:0050794;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246;gene-specific transcriptional regulator#PC00264 HUMAN|Ensembl=ENSG00000284779.3|UniProtKB=A0A2R8Y747 A0A2R8Y747 PTHR11454:SF32 INSULIN/INSULIN GROWTH FACTOR INSULIN, ISOFORM 2 molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;molecular function activator activity#GO:0140677;hormone activity#GO:0005179;protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 growth factor#PC00112 HUMAN|HGNC=33277|UniProtKB=P0C2L3 P0C2L3 FAM163B PTHR31396:SF2 PROTEIN FAM163B MEMBER PROTEIN FAM163B HUMAN|HGNC=17294|UniProtKB=Q5VWQ8 Q5VWQ8 DAB2IP PTHR10194:SF26 RAS GTPASE-ACTIVATING PROTEINS DISABLED HOMOLOG 2-INTERACTING PROTEIN GTPase-activating protein#PC00257 EGF receptor signaling pathway#P00018>GAP#P00546 HUMAN|HGNC=53552|UniProtKB=A0A1B0GWI6 A0A1B0GWI6 CXorf49C PTHR31866:SF3 GENE 4779-RELATED SUBFAMILY NOT NAMED HUMAN|HGNC=17819|UniProtKB=Q9BXI3 Q9BXI3 NT5C1A PTHR31367:SF2 CYTOSOLIC 5'-NUCLEOTIDASE 1 FAMILY MEMBER CYTOSOLIC 5'-NUCLEOTIDASE 1A hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;nucleotidase activity#GO:0008252;5'-nucleotidase activity#GO:0008253;catalytic activity#GO:0003824 cellular process#GO:0009987;purine-containing compound metabolic process#GO:0072521;carbohydrate derivative metabolic process#GO:1901135;adenosine metabolic process#GO:0046085;primary metabolic process#GO:0044238;nucleobase-containing compound metabolic process#GO:0006139;nucleoside metabolic process#GO:0009116;small molecule metabolic process#GO:0044281;purine nucleoside metabolic process#GO:0042278;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=15870|UniProtKB=Q9BUV8 Q9BUV8 RAB5IF PTHR12906:SF0 PROTEIN C20ORF24 RAB5-INTERACTING PROTEIN GEL COMPLEX SUBUNIT OPTI HUMAN|HGNC=5914|UniProtKB=A0A0A0MS00 A0A0A0MS00 IGLV3-32 PTHR23267:SF454 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN LAMBDA VARIABLE 3-19-RELATED response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 protein-containing complex#GO:0032991 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=15600|UniProtKB=Q8TB52 Q8TB52 FBXO30 PTHR15933:SF13 PROTEIN CBG16327 F-BOX ONLY PROTEIN 30 HUMAN|HGNC=29304|UniProtKB=Q2YD98 Q2YD98 UVSSA PTHR28670:SF1 UV-STIMULATED SCAFFOLD PROTEIN A UV-STIMULATED SCAFFOLD PROTEIN A RNA polymerase II complex binding#GO:0000993;protein binding#GO:0005515;RNA polymerase core enzyme binding#GO:0043175;binding#GO:0005488;enzyme binding#GO:0019899;RNA polymerase binding#GO:0070063 nucleobase-containing compound metabolic process#GO:0006139;nucleotide-excision repair#GO:0006289;cellular process#GO:0009987;response to radiation#GO:0009314;response to stress#GO:0006950;macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;response to UV#GO:0009411;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;response to stimulus#GO:0050896;response to light stimulus#GO:0009416;cellular response to stimulus#GO:0051716;response to abiotic stimulus#GO:0009628;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular response to stress#GO:0033554 intracellular anatomical structure#GO:0005622;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;chromosome#GO:0005694 HUMAN|HGNC=5144|UniProtKB=P84074 P84074 HPCA PTHR23055:SF57 CALCIUM BINDING PROTEINS NEURON-SPECIFIC CALCIUM-BINDING PROTEIN HIPPOCALCIN calcium ion binding#GO:0005509;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;cation binding#GO:0043169;metal ion binding#GO:0046872 calmodulin-related#PC00061 HUMAN|HGNC=5861|UniProtKB=A0M8Q6 A0M8Q6 IGLC7 PTHR23266:SF296 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN LAMBDA CONSTANT 7 antigen binding#GO:0003823;binding#GO:0005488 immune system process#GO:0002376;immune effector process#GO:0002252;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;immune response#GO:0006955;response to stimulus#GO:0050896;adaptive immune response#GO:0002250 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=49897|UniProtKB=Q6A1A2 Q6A1A2 PDPK2P PTHR24356:SF449 SERINE/THREONINE-PROTEIN KINASE 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674 cell surface receptor signaling pathway#GO:0007166;cellular response to insulin stimulus#GO:0032869;response to hormone#GO:0009725;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;cellular process#GO:0009987;response to chemical#GO:0042221;cellular response to nitrogen compound#GO:1901699;biological regulation#GO:0065007;response to peptide hormone#GO:0043434;cellular response to chemical stimulus#GO:0070887;response to oxygen-containing compound#GO:1901700;insulin receptor signaling pathway#GO:0008286;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;response to nitrogen compound#GO:1901698;intracellular signal transduction#GO:0035556;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;response to insulin#GO:0032868;cellular response to stimulus#GO:0051716;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;cellular response to hormone stimulus#GO:0032870;regulation of cellular process#GO:0050794;signaling#GO:0023052;cellular response to peptide hormone stimulus#GO:0071375 non-receptor serine/threonine protein kinase#PC00167 p53 pathway#P00059>PDK1/2#P04616;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PDK1#P00831;PI3 kinase pathway#P00048>P110ACT#P01177;Ras Pathway#P04393>PDK#P04555;Interleukin signaling pathway#P00036>PDK1/2#P00985;PI3 kinase pathway#P00048>PDK1#P01196;CCKR signaling map#P06959>PDPK1#P07162;PI3 kinase pathway#P00048>PDK1 ACT#P01190;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>PDK1/2#P00903;PDGF signaling pathway#P00047>PDK1/2#P01164;p53 pathway feedback loops 2#P04398>PDK1/2#P04656 HUMAN|HGNC=6585|UniProtKB=P22888 P22888 LHCGR PTHR24372:SF1 GLYCOPROTEIN HORMONE RECEPTOR LUTROPIN-CHORIOGONADOTROPIC HORMONE RECEPTOR signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;molecular transducer activity#GO:0060089;G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888 phospholipase C-activating G protein-coupled receptor signaling pathway#GO:0007200;system development#GO:0048731;female gonad development#GO:0008585;multicellular organismal reproductive process#GO:0048609;reproductive system development#GO:0061458;cell communication#GO:0007154;anatomical structure development#GO:0048856;cellular response to stimulus#GO:0051716;developmental process involved in reproduction#GO:0003006;reproductive process#GO:0022414;regulation of cellular process#GO:0050794;developmental process#GO:0032502;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;male sex differentiation#GO:0046661;development of primary male sexual characteristics#GO:0046546;biological regulation#GO:0065007;gonad development#GO:0008406;multicellular organismal process#GO:0032501;rhythmic process#GO:0048511;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;animal gross anatomical part developmental process#GO:0160108;hormone-mediated signaling pathway#GO:0009755;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;signaling#GO:0023052;reproductive structure development#GO:0048608;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;cellular response to hormone stimulus#GO:0032870;development of primary sexual characteristics#GO:0045137;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;multicellular organism development#GO:0007275;animal organ development#GO:0048513;signal transduction#GO:0007165;male gonad development#GO:0008584;cellular process#GO:0009987;sex differentiation#GO:0007548;response to hormone#GO:0009725;response to chemical#GO:0042221 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021 HUMAN|HGNC=12833|UniProtKB=P13010 P13010 XRCC5 PTHR12604:SF4 KU AUTOANTIGEN DNA HELICASE DNA REPAIR PROTEIN KU80 binding#GO:0005488;nucleic acid binding#GO:0003676;DNA binding#GO:0003677;telomeric repeat DNA binding#GO:0042162;sequence-specific DNA binding#GO:0043565;double-stranded DNA binding#GO:0003690 cellular response to stress#GO:0033554;telomere organization#GO:0032200;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA damage response#GO:0006974;double-strand break repair via nonhomologous end joining#GO:0006303;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;double-strand break repair#GO:0006302;telomere maintenance#GO:0000723;chromosome organization#GO:0051276;response to stress#GO:0006950;organelle organization#GO:0006996;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139 nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 DNA helicase#PC00011 HUMAN|HGNC=24839|UniProtKB=Q9BWT6 Q9BWT6 MND1 PTHR31398:SF0 MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG cellular process#GO:0009987;organelle organization#GO:0006996;nucleobase-containing compound metabolic process#GO:0006139;DNA recombination#GO:0006310;DNA metabolic process#GO:0006259;meiotic cell cycle#GO:0051321;metabolic process#GO:0008152;meiotic nuclear division#GO:0140013;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;cell cycle process#GO:0022402;reciprocal homologous recombination#GO:0140527;meiosis I#GO:0007127;meiotic cell cycle process#GO:1903046;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;cell cycle#GO:0007049;reproductive process#GO:0022414;homologous recombination#GO:0035825;reciprocal meiotic recombination#GO:0007131;sexual reproduction#GO:0019953;nuclear division#GO:0000280;meiosis I cell cycle process#GO:0061982;organelle fission#GO:0048285 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=17064|UniProtKB=O00472 O00472 ELL2 PTHR23288:SF8 OCCLUDIN AND RNA POLYMERASE II ELONGATION FACTOR ELL RNA POLYMERASE II ELONGATION FACTOR ELL2 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690 regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of DNA-templated transcription, elongation#GO:0032786;snRNA transcription#GO:0009301;regulation of biological process#GO:0050789;RNA metabolic process#GO:0016070;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;nucleic acid biosynthetic process#GO:0141187;regulation of transcription elongation by RNA polymerase II#GO:0034243;regulation of DNA-templated transcription elongation#GO:0032784;gene expression#GO:0010467;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;nucleobase-containing compound biosynthetic process#GO:0034654;positive regulation of transcription by RNA polymerase II#GO:0045944;metabolic process#GO:0008152;positive regulation of RNA metabolic process#GO:0051254;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;snRNA transcription by RNA polymerase II#GO:0042795;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;snRNA metabolic process#GO:0016073;positive regulation of biosynthetic process#GO:0009891;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;biosynthetic process#GO:0009058;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;macromolecule biosynthetic process#GO:0009059;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;transcription by RNA polymerase II#GO:0006366 organelle#GO:0043226;nucleoplasm#GO:0005654;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;transcription elongation factor complex#GO:0008023;intracellular membrane-bounded organelle#GO:0043231;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 general transcription factor#PC00259 HUMAN|HGNC=2169|UniProtKB=P26441 P26441 CNTF PTHR15196:SF0 CILIARY NEUROTROPHIC FACTOR CILIARY NEUROTROPHIC FACTOR signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;growth factor activity#GO:0008083;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;protein binding#GO:0005515;molecular function activator activity#GO:0140677;cytokine activity#GO:0005125;cytokine receptor binding#GO:0005126;binding#GO:0005488;signaling receptor binding#GO:0005102 cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;cell development#GO:0048468;signaling#GO:0023052;central nervous system development#GO:0007417;response to stimulus#GO:0050896;cell differentiation#GO:0030154;regulation of cellular component organization#GO:0051128;positive regulation of cellular component organization#GO:0051130;animal gross anatomical part developmental process#GO:0160108;positive regulation of neuron projection development#GO:0010976;response to peptide#GO:1901652;regulation of cellular response to stress#GO:0080135;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of neuron projection development#GO:0010975;negative regulation of programmed cell death#GO:0043069;positive regulation of biological process#GO:0048518;negative regulation of neuron apoptotic process#GO:0043524;response to stress#GO:0006950;regulation of response to wounding#GO:1903034;regulation of neuron apoptotic process#GO:0043523;nervous system development#GO:0007399;cell surface receptor signaling pathway via STAT#GO:0097696;regulation of response to external stimulus#GO:0032101;response to cytokine#GO:0034097;response to chemical#GO:0042221;cell surface receptor signaling pathway#GO:0007166;regulation of apoptotic process#GO:0042981;gliogenesis#GO:0042063;positive regulation of response to external stimulus#GO:0032103;multicellular organism development#GO:0007275;cellular response to stimulus#GO:0051716;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;positive regulation of cell projection organization#GO:0031346;cell activation#GO:0001775;inflammatory response#GO:0006954;cytokine-mediated signaling pathway#GO:0019221;system development#GO:0048731;anatomical structure development#GO:0048856;cell communication#GO:0007154;positive regulation of cellular process#GO:0048522;biological regulation#GO:0065007;glial cell differentiation#GO:0010001;multicellular organismal process#GO:0032501;positive regulation of response to stimulus#GO:0048584;negative regulation of apoptotic process#GO:0043066;cell surface receptor signaling pathway via JAK-STAT#GO:0007259;regulation of response to stimulus#GO:0048583;developmental process#GO:0032502;positive regulation of developmental process#GO:0051094;negative regulation of cellular process#GO:0048523;regulation of response to stress#GO:0080134;regulation of cell projection organization#GO:0031344;defense response#GO:0006952;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;regulation of plasma membrane bounded cell projection organization#GO:0120035 cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;neuronal cell body#GO:0043025;somatodendritic compartment#GO:0036477;cell projection#GO:0042995;neuron projection#GO:0043005;cell body#GO:0044297;axon#GO:0030424 HUMAN|HGNC=9490|UniProtKB=P98073 P98073 TMPRSS15 PTHR24253:SF71 TRANSMEMBRANE PROTEASE SERINE ENTEROPEPTIDASE serine hydrolase activity#GO:0017171;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;serine-type peptidase activity#GO:0008236 metabolic process#GO:0008152;proteolysis#GO:0006508;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;protein processing#GO:0016485;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058 membrane#GO:0016020;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;protease#PC00190;serine protease#PC00203 HUMAN|HGNC=16185|UniProtKB=P60602 P60602 ROMO1 PTHR28525:SF1 REACTIVE OXYGEN SPECIES MODULATOR 1 REACTIVE OXYGEN SPECIES MODULATOR 1 cellular component organization#GO:0016043;protein localization to mitochondrion#GO:0070585;protein localization to organelle#GO:0033365;mitochondrial transport#GO:0006839;mitochondrial transmembrane transport#GO:1990542;cellular localization#GO:0051641;transmembrane transport#GO:0055085;localization#GO:0051179;protein transport#GO:0015031;organelle organization#GO:0006996;macromolecule localization#GO:0033036;inner mitochondrial membrane organization#GO:0007007;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;mitochondrial membrane organization#GO:0007006;protein import into mitochondrial matrix#GO:0030150;protein insertion into mitochondrial inner membrane#GO:0045039;mitochondrion organization#GO:0007005;membrane organization#GO:0061024;mitochondrial protein import pathway#GO:7770058;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;protein transmembrane transport#GO:0071806;transport#GO:0006810;protein transmembrane import into intracellular organelle#GO:0044743;intracellular protein transmembrane transport#GO:0065002;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;establishment of protein localization to organelle#GO:0072594;intracellular protein localization#GO:0008104 organelle membrane#GO:0031090;inner mitochondrial membrane protein complex#GO:0098800;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;TIM23 mitochondrial import inner membrane translocase complex#GO:0005744;mitochondrial membrane#GO:0031966;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;organelle envelope#GO:0031967;membrane protein complex#GO:0098796 HUMAN|HGNC=11024|UniProtKB=P57057 P57057 SLC37A1 PTHR43184:SF11 MAJOR FACILITATOR SUPERFAMILY TRANSPORTER 16, ISOFORM B GLUCOSE-6-PHOSPHATE EXCHANGER SLC37A1 active transmembrane transporter activity#GO:0022804;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;secondary active transmembrane transporter activity#GO:0015291;antiporter activity#GO:0015297;carbohydrate derivative transmembrane transporter activity#GO:1901505;organophosphate ester transmembrane transporter activity#GO:0015605;phosphate transmembrane transporter activity#GO:0005315 organophosphate ester transport#GO:0015748;phosphate ion transport#GO:0006817;cellular process#GO:0009987;carbohydrate derivative transport#GO:1901264;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;inorganic anion transport#GO:0015698;transport#GO:0006810 intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum membrane#GO:0005789;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane#GO:0016020 transporter#PC00227 HUMAN|HGNC=9360|UniProtKB=P14222 P14222 PRF1 PTHR46096:SF3 PERFORIN-1 PERFORIN-1 wide pore channel activity#GO:0022829;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 cellular process#GO:0009987;immune response#GO:0006955;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;adaptive immune response#GO:0002250;response to other organism#GO:0051707;multicellular organismal process#GO:0032501;lymphocyte activation#GO:0046649;immune effector process#GO:0002252;cell killing#GO:0001906;cell-cell recognition#GO:0009988;defense response#GO:0006952;response to external stimulus#GO:0009605;leukocyte mediated cytotoxicity#GO:0001909;leukocyte activation#GO:0045321;defense response to virus#GO:0051607;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;cell recognition#GO:0008037;cell activation#GO:0001775;T cell mediated immunity#GO:0002456;immune system process#GO:0002376;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;response to virus#GO:0009615 membrane#GO:0016020;cellular anatomical structure#GO:0110165 HUMAN|HGNC=14334|UniProtKB=Q969V6 Q969V6 MRTFA PTHR22793:SF6 MYOCARDIN-RELATED TRANSCRIPTION FACTOR-RELATED MYOCARDIN-RELATED TRANSCRIPTION FACTOR A muscle structure development#GO:0061061;cell differentiation#GO:0030154;cellular process#GO:0009987;muscle cell differentiation#GO:0042692;cellular developmental process#GO:0048869;anatomical structure development#GO:0048856;developmental process#GO:0032502;animal gross anatomical part developmental process#GO:0160108 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HUMAN|HGNC=12672|UniProtKB=P45880 P45880 VDAC2 PTHR11743:SF12 VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL NON-SELECTIVE VOLTAGE-GATED ION CHANNEL VDAC2 voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;voltage-gated channel activity#GO:0022832;monoatomic anion channel activity#GO:0005253;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic anion transmembrane transporter activity#GO:0008509;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;voltage-gated monoatomic anion channel activity#GO:0008308 mitochondrial transport#GO:0006839;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;cellular localization#GO:0051641;mitochondrial transmembrane transport#GO:1990542;transport#GO:0006810;intracellular transport#GO:0046907 mitochondrion#GO:0005739;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;outer membrane#GO:0019867;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;membrane#GO:0016020;cytoplasm#GO:0005737;organelle outer membrane#GO:0031968;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;mitochondrial outer membrane#GO:0005741 voltage-gated ion channel#PC00241 HUMAN|HGNC=24215|UniProtKB=Q9HD20 Q9HD20 ATP13A1 PTHR45630:SF20 CATION-TRANSPORTING ATPASE-RELATED ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE protein carrier activity#GO:0140597;ATP-dependent activity#GO:0140657;molecular carrier activity#GO:0140104 homeostatic process#GO:0042592;intracellular monoatomic ion homeostasis#GO:0006873;cellular localization#GO:0051641;transmembrane transport#GO:0055085;localization#GO:0051179;inorganic ion homeostasis#GO:0098771;localization within membrane#GO:0051668;calcium ion homeostasis#GO:0055074;cellular process#GO:0009987;establishment of protein localization#GO:0045184;monoatomic ion homeostasis#GO:0050801;establishment of protein localization to membrane#GO:0090150;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;establishment of localization#GO:0051234;intracellular monoatomic cation homeostasis#GO:0030003;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175 primary active transporter#PC00068 HUMAN|HGNC=53|UniProtKB=Q92887 Q92887 ABCC2 PTHR24223:SF176 ATP-BINDING CASSETTE SUB-FAMILY C ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 2 active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399;xenobiotic transmembrane transporter activity#GO:0042910;ATP-dependent activity#GO:0140657;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;ATPase-coupled transmembrane transporter activity#GO:0042626 localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;transport#GO:0006810;cellular process#GO:0009987 apical part of cell#GO:0045177;cell periphery#GO:0071944;apical plasma membrane#GO:0016324;membrane#GO:0016020;plasma membrane#GO:0005886;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165 ATP-binding cassette (ABC) transporter#PC00003 HUMAN|HGNC=16162|UniProtKB=Q8N2H4 Q8N2H4 SYS1 PTHR12952:SF0 SYS1 PROTEIN SYS1 HOMOLOG vesicle-mediated transport to the plasma membrane#GO:0098876;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;Golgi vesicle transport#GO:0048193;transport#GO:0006810;intracellular transport#GO:0046907;protein localization to cell periphery#GO:1990778;protein localization to Golgi apparatus#GO:0034067;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;macromolecule localization#GO:0033036;establishment of protein localization to membrane#GO:0090150;protein transport#GO:0015031;post-Golgi vesicle-mediated transport#GO:0006892;cellular localization#GO:0051641;localization#GO:0051179;localization within membrane#GO:0051668;establishment of protein localization to plasma membrane#GO:0061951;cytosolic transport#GO:0016482;Golgi to plasma membrane protein transport#GO:0043001;protein localization to organelle#GO:0033365;Golgi to plasma membrane transport#GO:0006893;Golgi to endosome transport#GO:0006895;protein localization to plasma membrane#GO:0072659;protein localization to membrane#GO:0072657 Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular organelle#GO:0043229;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 membrane traffic protein#PC00150 HUMAN|HGNC=14680|UniProtKB=Q7Z4V5 Q7Z4V5 HDGFL2 PTHR12550:SF18 HEPATOMA-DERIVED GROWTH FACTOR-RELATED HEPATOMA-DERIVED GROWTH FACTOR-RELATED PROTEIN 2 chromatin-protein adaptor activity#GO:0140463;histone H3 reader activity#GO:0140006;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;histone reader activity#GO:0140566;histone H3K9me2/3 reader activity#GO:0062072 chromatin remodeling#GO:0006338;chromatin organization#GO:0006325;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 transcription cofactor#PC00217;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=7124|UniProtKB=Q16655 Q16655 MLANA PTHR15305:SF0 MELANOMA ANTIGEN RECOGNIZED BY T-CELLS 1 MELANOMA ANTIGEN RECOGNIZED BY T-CELLS 1 nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;cytoplasm#GO:0005737;melanosome#GO:0042470;trans-Golgi network#GO:0005802;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;organelle membrane#GO:0031090;Golgi apparatus#GO:0005794;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783 HUMAN|HGNC=32286|UniProtKB=P0DPD5 P0DPD5 ZNF723 PTHR24384:SF203 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED ZINC FINGER PROTEIN 723 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 DNA-binding transcription factor#PC00218 HUMAN|HGNC=29430|UniProtKB=Q5HYW3 Q5HYW3 RTL5 PTHR15503:SF51 LDOC1 RELATED RETROTRANSPOSON GAG-LIKE PROTEIN 5 viral or transposable element protein#PC00237 HUMAN|HGNC=17399|UniProtKB=A7KAX9 A7KAX9 ARHGAP32 PTHR15729:SF13 CDC42 GTPASE-ACTIVATING PROTEIN RHO GTPASE-ACTIVATING PROTEIN 32 molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;enzyme activator activity#GO:0008047 intracellular signal transduction#GO:0035556;regulation of biological quality#GO:0065008;cell communication#GO:0007154;regulation of synapse structure or activity#GO:0050803;regulation of dendritic spine morphogenesis#GO:0061001;regulation of synapse organization#GO:0050807;regulation of cell junction assembly#GO:1901888;regulation of developmental process#GO:0050793;signaling#GO:0023052;regulation of cellular component biogenesis#GO:0044087;response to stimulus#GO:0050896;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;regulation of postsynapse organization#GO:0099175;regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of anatomical structure morphogenesis#GO:0022603;regulation of cell projection organization#GO:0031344;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;intracellular signaling cassette#GO:0141124;regulation of synapse assembly#GO:0051963;regulation of neuron projection development#GO:0010975;signal transduction#GO:0007165;cellular process#GO:0009987 organelle#GO:0043226;asymmetric synapse#GO:0032279;postsynaptic specialization#GO:0099572;neuron to neuron synapse#GO:0098984;glutamatergic synapse#GO:0098978;cellular anatomical structure#GO:0110165;synapse#GO:0045202;postsynapse#GO:0098794;cell junction#GO:0030054;postsynaptic density#GO:0014069 protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 Gonadotropin-releasing hormone receptor pathway#P06664>RICS#G06882;Gonadotropin-releasing hormone receptor pathway#P06664>RICS#P06765;Gonadotropin-releasing hormone receptor pathway#P06664>RICS#G06669 HUMAN|HGNC=25935|UniProtKB=Q9NXX6 Q9NXX6 NSMCE4A PTHR16140:SF2 NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4 NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4 HOMOLOG A macromolecule metabolic process#GO:0043170;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA damage response#GO:0006974;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139;response to stress#GO:0006950;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 nucleus#GO:0005634;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex#GO:1990234;condensed chromosome#GO:0000793;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228 HUMAN|HGNC=3573|UniProtKB=Q13158 Q13158 FADD PTHR15077:SF9 FAS-ASSOCIATING DEATH DOMAIN-CONTAINING PROTEIN FADD FAS-ASSOCIATED DEATH DOMAIN PROTEIN Apoptosis signaling pathway#P00006>FADD#P00327;FAS signaling pathway#P00020>FADD#P00622 HUMAN|HGNC=26285|UniProtKB=Q5SXH7 Q5SXH7 PLEKHS1 PTHR47014:SF1 PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY S MEMBER 1 PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY S MEMBER 1 HUMAN|HGNC=6023|UniProtKB=P13232 P13232 IL7 PTHR48492:SF1 INTERLEUKIN-7 INTERLEUKIN-7 signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;cytokine activity#GO:0005125;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677 interleukin-7-mediated signaling pathway#GO:0038111;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;response to chemical#GO:0042221;response to cytokine#GO:0034097;cellular process#GO:0009987;signal transduction#GO:0007165;response to peptide#GO:1901652;cell communication#GO:0007154;cytokine-mediated signaling pathway#GO:0019221;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 Interleukin signaling pathway#P00036>Interleukin#P00970 HUMAN|HGNC=15388|UniProtKB=Q8NGA5 Q8NGA5 OR10H4 PTHR26453:SF613 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 10H4 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;nervous system process#GO:0050877;sensory perception#GO:0007600;system process#GO:0003008;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;detection of chemical stimulus#GO:0009593;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;response to stimulus#GO:0050896;response to chemical#GO:0042221 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=26277|UniProtKB=Q6P589 Q6P589 TNFAIP8L2 PTHR12757:SF4 TUMOR NECROSIS FACTOR INDUCED PROTEIN TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 8-LIKE PROTEIN 2 negative regulation of T cell activation#GO:0050868;regulation of inflammatory response#GO:0050727;regulation of defense response#GO:0031347;negative regulation of multicellular organismal process#GO:0051241;negative regulation of leukocyte cell-cell adhesion#GO:1903038;regulation of cell communication#GO:0010646;negative regulation of inflammatory response#GO:0050728;regulation of cell-cell adhesion#GO:0022407;regulation of immune system process#GO:0002682;negative regulation of defense response#GO:0031348;regulation of cellular process#GO:0050794;regulation of response to stimulus#GO:0048583;regulation of leukocyte cell-cell adhesion#GO:1903037;regulation of response to stress#GO:0080134;negative regulation of cellular process#GO:0048523;negative regulation of cell activation#GO:0050866;negative regulation of immune system process#GO:0002683;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of cell adhesion#GO:0007162;regulation of cell adhesion#GO:0030155;negative regulation of response to stimulus#GO:0048585;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;regulation of biological process#GO:0050789;regulation of cell activation#GO:0050865;regulation of leukocyte activation#GO:0002694;negative regulation of biological process#GO:0048519;regulation of lymphocyte activation#GO:0051249;negative regulation of response to external stimulus#GO:0032102;negative regulation of leukocyte activation#GO:0002695;negative regulation of lymphocyte activation#GO:0051250;regulation of multicellular organismal process#GO:0051239;negative regulation of cell-cell adhesion#GO:0022408;regulation of response to external stimulus#GO:0032101;regulation of T cell activation#GO:0050863 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=4656|UniProtKB=Q13888 Q13888 GTF2H2 PTHR12695:SF2 GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2 GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2-RELATED macromolecule metabolic process#GO:0043170;DNA metabolic process#GO:0006259;nucleobase-containing compound biosynthetic process#GO:0034654;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA damage response#GO:0006974;transcription by RNA polymerase II#GO:0006366;gene expression#GO:0010467;nucleotide-excision repair#GO:0006289;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;response to stress#GO:0006950;transcription initiation at RNA polymerase II promoter#GO:0006367;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;cellular response to stress#GO:0033554;DNA-templated transcription initiation#GO:0006352;response to stimulus#GO:0050896;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular response to stimulus#GO:0051716 intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;transcription factor TFIIH holo complex#GO:0005675;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;RNA polymerase II, holoenzyme#GO:0016591;membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;transcription factor TFIIH core complex#GO:0000439;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;transcription regulator complex#GO:0005667;intracellular protein-containing complex#GO:0140535;protein kinase complex#GO:1902911;membrane-enclosed lumen#GO:0031974;RNA polymerase II transcription regulator complex#GO:0090575;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;protein-containing complex#GO:0032991;cyclin-dependent protein kinase holoenzyme complex#GO:0000307 RNA metabolism protein#PC00031;general transcription factor#PC00259 HUMAN|HGNC=390|UniProtKB=O95154 O95154 AKR7A3 PTHR43625:SF11 AFLATOXIN B1 ALDEHYDE REDUCTASE AFLATOXIN B1 ALDEHYDE REDUCTASE MEMBER 4-RELATED catalytic activity#GO:0003824;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;alcohol dehydrogenase (NADP+) activity#GO:0008106;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614 detoxification#GO:0098754;response to toxic substance#GO:0009636;response to stimulus#GO:0050896;response to chemical#GO:0042221;catabolic process#GO:0009056;cellular process#GO:0009987;secondary metabolic process#GO:0019748;metabolic process#GO:0008152 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 oxidoreductase#PC00176;reductase#PC00198 HUMAN|HGNC=6763|UniProtKB=Q13257 Q13257 MAD2L1 PTHR11842:SF13 MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2 MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A negative regulation of chromosome segregation#GO:0051985;regulation of chromosome segregation#GO:0051983;negative regulation of metaphase/anaphase transition of cell cycle#GO:1902100;negative regulation of mitotic sister chromatid segregation#GO:0033048;negative regulation of cell cycle#GO:0045786;negative regulation of sister chromatid segregation#GO:0033046;cellular process#GO:0009987;signal transduction#GO:0007165;mitotic spindle assembly checkpoint signaling#GO:0007094;negative regulation of mitotic cell cycle phase transition#GO:1901991;regulation of chromosome separation#GO:1905818;cell cycle checkpoint signaling#GO:0000075;regulation of cell cycle process#GO:0010564;negative regulation of mitotic sister chromatid separation#GO:2000816;regulation of mitotic cell cycle phase transition#GO:1901990;negative regulation of mitotic cell cycle#GO:0045930;negative regulation of cell cycle phase transition#GO:1901988;negative regulation of biological process#GO:0048519;cell cycle process#GO:0022402;regulation of organelle organization#GO:0033043;negative regulation of mitotic nuclear division#GO:0045839;regulation of biological process#GO:0050789;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;regulation of sister chromatid segregation#GO:0033045;regulation of cell cycle#GO:0051726;signaling#GO:0023052;regulation of chromosome organization#GO:0033044;negative regulation of cellular process#GO:0048523;negative regulation of cell cycle process#GO:0010948;regulation of mitotic sister chromatid separation#GO:0010965;mitotic cell cycle process#GO:1903047;regulation of mitotic nuclear division#GO:0007088;negative regulation of chromosome separation#GO:1905819;regulation of mitotic cell cycle#GO:0007346;regulation of mitotic metaphase/anaphase transition#GO:0030071;negative regulation of nuclear division#GO:0051784;regulation of nuclear division#GO:0051783;biological regulation#GO:0065007;negative regulation of chromosome organization#GO:2001251;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of mitotic sister chromatid segregation#GO:0033047;negative regulation of organelle organization#GO:0010639;negative regulation of cellular component organization#GO:0051129;mitotic cell cycle checkpoint signaling#GO:0007093;cell cycle#GO:0007049;regulation of cell cycle phase transition#GO:1901987;cellular response to stimulus#GO:0051716;negative regulation of mitotic metaphase/anaphase transition#GO:0045841;regulation of cellular process#GO:0050794;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;mitotic cell cycle#GO:0000278 intracellular organelle#GO:0043229;condensed chromosome#GO:0000793;chromosome, centromeric region#GO:0000775;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;kinetochore#GO:0000776;condensed chromosome, centromeric region#GO:0000779;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;supramolecular complex#GO:0099080;organelle#GO:0043226 HUMAN|HGNC=10922|UniProtKB=P53985 P53985 SLC16A1 PTHR11360:SF24 MONOCARBOXYLATE TRANSPORTER MONOCARBOXYLATE TRANSPORTER 1 secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;proton transmembrane transporter activity#GO:0015078;active transmembrane transporter activity#GO:0022804;monocarboxylic acid transmembrane transporter activity#GO:0008028;solute:monoatomic cation symporter activity#GO:0015294;monoatomic ion transmembrane transporter activity#GO:0015075;symporter activity#GO:0015293;carboxylic acid transmembrane transporter activity#GO:0046943;solute:proton symporter activity#GO:0015295;monoatomic cation transmembrane transporter activity#GO:0008324 carboxylic acid transmembrane transport#GO:1905039;cellular process#GO:0009987;monocarboxylic acid transport#GO:0015718;organic hydroxy compound transport#GO:0015850;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;transport#GO:0006810;carboxylic acid transport#GO:0046942;organic acid transport#GO:0015849 membrane#GO:0016020;basolateral plasma membrane#GO:0016323;basal part of cell#GO:0045178;cell periphery#GO:0071944;basal plasma membrane#GO:0009925;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;plasma membrane#GO:0005886 transporter#PC00227 HUMAN|HGNC=11930|UniProtKB=O43557 O43557 TNFSF14 PTHR11471:SF34 TUMOR NECROSIS FACTOR FAMILY MEMBER TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 14 receptor ligand activity#GO:0048018;cytokine activity#GO:0005125;signaling receptor regulator activity#GO:0030545;signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772 regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of extrinsic apoptotic signaling pathway#GO:2001238;regulation of canonical NF-kappaB signal transduction#GO:0043122;positive regulation of cellular process#GO:0048522;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of apoptotic signaling pathway#GO:2001233;cell communication#GO:0007154;regulation of extrinsic apoptotic signaling pathway#GO:2001236;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;positive regulation of apoptotic signaling pathway#GO:2001235;regulation of cell communication#GO:0010646;regulation of apoptotic process#GO:0042981;cell surface receptor signaling pathway#GO:0007166;positive regulation of canonical NF-kappaB signal transduction#GO:0043123;positive regulation of apoptotic process#GO:0043065;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;regulation of programmed cell death#GO:0043067;regulation of biological process#GO:0050789;positive regulation of programmed cell death#GO:0043068;response to stimulus#GO:0050896;signaling#GO:0023052 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HUMAN|HGNC=18508|UniProtKB=Q96RD9 Q96RD9 FCRL5 PTHR11481:SF68 IMMUNOGLOBULIN FC RECEPTOR FC RECEPTOR-LIKE PROTEIN 5 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;signal transduction#GO:0007165;immune response#GO:0006955;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;immune system process#GO:0002376;cell communication#GO:0007154 membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;plasma membrane#GO:0005886 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=11179|UniProtKB=P00441 P00441 SOD1 PTHR10003:SF112 SUPEROXIDE DISMUTASE CU-ZN -RELATED SUPEROXIDE DISMUTASE [CU-ZN] catalytic activity#GO:0003824;copper ion binding#GO:0005507;antioxidant activity#GO:0016209;oxidoreductase activity#GO:0016491;transition metal ion binding#GO:0046914;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;cation binding#GO:0043169;metal ion binding#GO:0046872 cellular detoxification#GO:1990748;cellular response to stress#GO:0033554;response to oxygen-containing compound#GO:1901700;cellular response to chemical stimulus#GO:0070887;response to toxic substance#GO:0009636;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;response to reactive oxygen species#GO:0000302;superoxide metabolic process#GO:0006801;cellular response to chemical stress#GO:0062197;response to oxidative stress#GO:0006979;reactive oxygen species metabolic process#GO:0072593;metabolic process#GO:0008152;cellular response to toxic substance#GO:0097237;detoxification#GO:0098754;cellular response to oxidative stress#GO:0034599;response to chemical#GO:0042221;cellular process#GO:0009987;cellular oxidant detoxification#GO:0098869;cellular response to oxygen-containing compound#GO:1901701;response to stress#GO:0006950 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;microbody#GO:0042579;mitochondrion#GO:0005739;peroxisome#GO:0005777;cytosol#GO:0005829 oxidoreductase#PC00176 HUMAN|HGNC=123|UniProtKB=P11117 P11117 ACP2 PTHR11567:SF180 ACID PHOSPHATASE-RELATED LYSOSOMAL ACID PHOSPHATASE hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;acid phosphatase activity#GO:0003993;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787 cellular process#GO:0009987;lytic vacuole organization#GO:0080171;lysosome organization#GO:0007040;cellular component organization#GO:0016043;organelle organization#GO:0006996;vacuole organization#GO:0007033;cellular component organization or biogenesis#GO:0071840 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;vacuole#GO:0005773;cellular anatomical structure#GO:0110165;organelle#GO:0043226;lysosome#GO:0005764;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;lytic vacuole#GO:0000323;intracellular organelle#GO:0043229 phosphatase#PC00181 HUMAN|HGNC=11362|UniProtKB=P42224 P42224 STAT1 PTHR11801:SF18 SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA_BETA DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;response to molecule of bacterial origin#GO:0002237;response to endogenous stimulus#GO:0009719;response to peptide#GO:1901652;response to oxygen-containing compound#GO:1901700;type I interferon-mediated signaling pathway#GO:0060337;cellular response to chemical stimulus#GO:0070887;immune system process#GO:0002376;cell surface receptor signaling pathway via STAT#GO:0097696;interleukin-9-mediated signaling pathway#GO:0038113;cellular response to lipid#GO:0071396;defense response to other organism#GO:0098542;response to lipid#GO:0033993;response to chemical#GO:0042221;response to cytokine#GO:0034097;cellular process#GO:0009987;defense response to symbiont#GO:0140546;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;response to hormone#GO:0009725;cellular response to lipopolysaccharide#GO:0071222;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;response to lipopolysaccharide#GO:0032496;interleukin-7-mediated signaling pathway#GO:0038111;cell surface receptor signaling pathway#GO:0007166;response to external biotic stimulus#GO:0043207;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;cellular response to stimulus#GO:0051716;cellular response to biotic stimulus#GO:0071216;regulation of RNA metabolic process#GO:0051252;response to nitrogen compound#GO:1901698;regulation of DNA-templated transcription#GO:0006355;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;response to bacterium#GO:0009617;lipopolysaccharide-mediated signaling pathway#GO:0031663;cytokine-mediated signaling pathway#GO:0019221;response to peptide hormone#GO:0043434;response to other organism#GO:0051707;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;immune response#GO:0006955;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;defense response#GO:0006952;regulation of gene expression#GO:0010468;response to external stimulus#GO:0009605;innate immune response#GO:0045087;regulation of biosynthetic process#GO:0009889;cellular response to molecule of bacterial origin#GO:0071219;cell surface receptor signaling pathway via JAK-STAT#GO:0007259 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;intracellular anatomical structure#GO:0005622;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229 immunoglobulin fold transcription factor#PC00251;Rel homology transcription factor#PC00252 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>STAT#P00832;JAK/STAT signaling pathway#P00038>STAT#P01027;Oxidative stress response#P00046>Stat1#P01125;Oxidative stress response#P00046>Myc#P01124;EGF receptor signaling pathway#P00018>STAT#P00561;PDGF signaling pathway#P00047>STAT#P01173;Interferon-gamma signaling pathway#P00035>STAT1#P00961;Angiogenesis#P00005>STAT1#P00218;Ras Pathway#P04393>Stat 1/3#P04566;p53 pathway feedback loops 2#P04398>Myc#P04649;Interleukin signaling pathway#P00036>STAT#P00996 HUMAN|HGNC=3768|UniProtKB=Q68DA7 Q68DA7 FMN1 PTHR13037:SF11 FORMIN FORMIN-1 binding#GO:0005488;microtubule binding#GO:0008017;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;protein binding#GO:0005515 actin filament-based process#GO:0030029;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cellular component organization or biogenesis#GO:0071840;actin filament bundle assembly#GO:0051017;actin filament bundle organization#GO:0061572;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular component organization#GO:0016043;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;actin cytoskeleton organization#GO:0030036 endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoskeleton#GO:0005856;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;membraneless organelle#GO:0043228;organelle membrane#GO:0031090;microtubule cytoskeleton#GO:0015630;membrane#GO:0016020;nucleus#GO:0005634;endomembrane system#GO:0012505;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737 HUMAN|HGNC=24140|UniProtKB=Q3V5L5 Q3V5L5 MGAT5B PTHR15075:SF6 ALPHA-MANNOSIDE BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE ALPHA-1,6-MANNOSYLGLYCOPROTEIN 6-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE B transferase activity#GO:0016740;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;glycosyltransferase activity#GO:0016757;catalytic activity, acting on a protein#GO:0140096;UDP-glycosyltransferase activity#GO:0008194;acetylglucosaminyltransferase activity#GO:0008375 macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;biosynthetic process#GO:0009058;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226 glycosyltransferase#PC00111;metabolite interconversion enzyme#PC00262;transferase#PC00220 HUMAN|HGNC=21643|UniProtKB=O95857 O95857 TSPAN13 PTHR19282:SF203 TETRASPANIN TETRASPANIN-13 scaffold/adaptor protein#PC00226 HUMAN|HGNC=410|UniProtKB=P43353 P43353 ALDH3B1 PTHR43570:SF2 ALDEHYDE DEHYDROGENASE ALDEHYDE DEHYDROGENASE FAMILY 3 MEMBER B1 oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the aldehyde or oxo group of donors#GO:0016903;catalytic activity#GO:0003824;oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor#GO:0016620;aldehyde dehydrogenase (NAD+) activity#GO:0004029 metabolic process#GO:0008152;cellular process#GO:0009987;aldehyde metabolic process#GO:0006081 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;plasma membrane#GO:0005886 dehydrogenase#PC00092 5-Hydroxytryptamine degredation#P04372>Aldehyde Dehydrogenase#P04402 HUMAN|HGNC=19254|UniProtKB=Q9NZF1 Q9NZF1 PLAC8 PTHR15907:SF32 DUF614 FAMILY PROTEIN-RELATED PLACENTA-SPECIFIC GENE 8 PROTEIN regulation of DNA-templated transcription#GO:0006355;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522 HUMAN|HGNC=19184|UniProtKB=Q8N1F8 Q8N1F8 STK11IP PTHR15454:SF75 NISCHARIN RELATED SERINE_THREONINE-PROTEIN KINASE 11-INTERACTING PROTEIN scaffold/adaptor protein#PC00226 HUMAN|HGNC=44408|UniProtKB=H3BV12 H3BV12 GOLGA8Q PTHR10881:SF62 GOLGIN SUBFAMILY A MEMBER-RELATED GOLGIN SUBFAMILY A CONSERVED DOMAIN-CONTAINING PROTEIN-RELATED cellular component organization or biogenesis#GO:0071840;endomembrane system organization#GO:0010256;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;Golgi organization#GO:0007030 organelle membrane#GO:0031090;cis-Golgi network#GO:0005801;Golgi apparatus#GO:0005794;endomembrane system#GO:0012505;Golgi cisterna#GO:0031985;cytoplasm#GO:0005737;Golgi cis cisterna#GO:0000137;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;Golgi stack#GO:0005795 membrane traffic protein#PC00150 HUMAN|HGNC=4951|UniProtKB=P79483 P79483 HLA-DRB3 PTHR19944:SF84 MHC CLASS II-RELATED HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR BETA 3 CHAIN binding#GO:0005488;peptide binding#GO:0042277;antigen binding#GO:0003823;protein-containing complex binding#GO:0044877 immune system process#GO:0002376;regulation of lymphocyte activation#GO:0051249;cellular component organization#GO:0016043;regulation of leukocyte activation#GO:0002694;regulation of cell activation#GO:0050865;positive regulation of multicellular organismal process#GO:0051240;protein-containing complex assembly#GO:0065003;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;positive regulation of leukocyte activation#GO:0002696;regulation of T cell activation#GO:0050863;cellular component assembly#GO:0022607;positive regulation of T cell activation#GO:0050870;regulation of multicellular organismal process#GO:0051239;positive regulation of immune system process#GO:0002684;positive regulation of cell-cell adhesion#GO:0022409;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;antigen processing and presentation#GO:0019882;positive regulation of lymphocyte activation#GO:0051251;regulation of immune response#GO:0050776;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of cell-cell adhesion#GO:0022407;positive regulation of cell adhesion#GO:0045785;regulation of leukocyte cell-cell adhesion#GO:1903037;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;regulation of cell adhesion#GO:0030155;positive regulation of response to stimulus#GO:0048584;positive regulation of cell activation#GO:0050867;biological regulation#GO:0065007;positive regulation of leukocyte cell-cell adhesion#GO:1903039;positive regulation of cellular process#GO:0048522 late endosome membrane#GO:0031902;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;vacuolar membrane#GO:0005774;lytic vacuole#GO:0000323;cell periphery#GO:0071944;lysosomal membrane#GO:0005765;membrane#GO:0016020;vesicle membrane#GO:0012506;cytoplasm#GO:0005737;plasma membrane#GO:0005886;vacuole#GO:0005773;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;late endosome#GO:0005770;cytoplasmic vesicle membrane#GO:0030659;endosome#GO:0005768;endosome membrane#GO:0010008;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;plasma membrane protein complex#GO:0098797;lysosome#GO:0005764;vesicle#GO:0031982;lytic vacuole membrane#GO:0098852;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 major histocompatibility complex protein#PC00149 HUMAN|HGNC=18572|UniProtKB=Q6YN16 Q6YN16 HSDL2 PTHR42808:SF3 HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 2 HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 2 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739 dehydrogenase#PC00092 HUMAN|HGNC=9954|UniProtKB=Q04864 Q04864 REL PTHR24169:SF4 NUCLEAR FACTOR NF-KAPPA-B PROTEIN PROTO-ONCOGENE C-REL sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987 intracellular signal transduction#GO:0035556;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;positive regulation of RNA metabolic process#GO:0051254;response to external biotic stimulus#GO:0043207;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of gene expression#GO:0010468;defense response#GO:0006952;response to external stimulus#GO:0009605;innate immune response#GO:0045087;regulation of biosynthetic process#GO:0009889;immune response#GO:0006955;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;response to other organism#GO:0051707;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;canonical NF-kappaB signal transduction#GO:0007249;immune system process#GO:0002376;response to peptide#GO:1901652;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of biological process#GO:0050789;biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;positive regulation of transcription by RNA polymerase II#GO:0045944;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;non-canonical NF-kappaB signal transduction#GO:0038061;defense response to symbiont#GO:0140546;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;intracellular signaling cassette#GO:0141124;defense response to other organism#GO:0098542;response to cytokine#GO:0034097;positive regulation of macromolecule metabolic process#GO:0010604;response to chemical#GO:0042221 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 Rel homology transcription factor#PC00252;DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 Toll receptor signaling pathway#P00054>NFkappaB#P01354;Apoptosis signaling pathway#P00006>NFkappaB#P00297;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>NFkappaB#P00859 HUMAN|HGNC=10896|UniProtKB=P12755 P12755 SKI PTHR10005:SF15 SKI ONCOGENE-RELATED SKI ONCOGENE RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;protein binding#GO:0005515;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;regulation of BMP signaling pathway#GO:0030510;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of signal transduction#GO:0009966;regulation of cellular response to growth factor stimulus#GO:0090287;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of response to stimulus#GO:0048585;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;negative regulation of BMP signaling pathway#GO:0030514;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of transforming growth factor beta receptor signaling pathway#GO:0017015;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092;regulation of cell communication#GO:0010646;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of signal transduction#GO:0009968;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of cell communication#GO:0010648;negative regulation of DNA-templated transcription#GO:0045892 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226 TGF-beta signaling pathway#P00052>Co-activators corepressors#P01282 HUMAN|HGNC=8077|UniProtKB=O95157 O95157 NXPH3 PTHR17103:SF14 NEUREXOPHILIN NEUREXOPHILIN-3 protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488 biological regulation#GO:0065007;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of trans-synaptic signaling#GO:0099177;regulation of biological process#GO:0050789;regulation of signaling#GO:0023051 GABA-ergic synapse#GO:0098982;cell junction#GO:0030054;synapse#GO:0045202;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HUMAN|HGNC=11948|UniProtKB=P13805 P13805 TNNT1 PTHR11521:SF6 TROPONIN T TROPONIN T, SLOW SKELETAL MUSCLE protein binding#GO:0005515;binding#GO:0005488;cytoskeletal protein binding#GO:0008092 cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;anatomical structure formation involved in morphogenesis#GO:0048646;striated muscle cell differentiation#GO:0051146;cellular anatomical entity morphogenesis#GO:0032989;cell differentiation#GO:0030154;cell development#GO:0048468;actomyosin structure organization#GO:0031032;skeletal muscle contraction#GO:0003009;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;muscle system process#GO:0003012;anatomical structure morphogenesis#GO:0009653;striated muscle cell development#GO:0055002;animal gross anatomical part developmental process#GO:0160108;nervous system process#GO:0050877;multicellular organismal process#GO:0032501;cellular developmental process#GO:0048869;system process#GO:0003008;muscle contraction#GO:0006936;developmental process#GO:0032502;actin cytoskeleton organization#GO:0030036;muscle structure development#GO:0061061;striated muscle contraction#GO:0006941;muscle cell development#GO:0055001;muscle cell differentiation#GO:0042692;myofibril assembly#GO:0030239;anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;cellular component assembly involved in morphogenesis#GO:0010927;organelle assembly#GO:0070925;actin filament-based process#GO:0030029;sarcomere organization#GO:0045214;neuromuscular process#GO:0050905 cellular anatomical structure#GO:0110165;organelle#GO:0043226;actin cytoskeleton#GO:0015629;myofibril#GO:0030016;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;contractile muscle fiber#GO:0043292;membraneless organelle#GO:0043228;sarcomere#GO:0030017;cytoskeleton#GO:0005856 actin binding motor protein#PC00040 HUMAN|HGNC=31928|UniProtKB=Q6ZNJ1 Q6ZNJ1 NBEAL2 PTHR13743:SF111 BEIGE/BEACH-RELATED NEUROBEACHIN-LIKE PROTEIN 2 anatomical structure formation involved in morphogenesis#GO:0048646;cellular developmental process#GO:0048869;anatomical structure development#GO:0048856;developmental process#GO:0032502;hemopoiesis#GO:0030097;cell development#GO:0048468;cell differentiation#GO:0030154;myeloid cell differentiation#GO:0030099;cell morphogenesis#GO:0000902;anatomical structure morphogenesis#GO:0009653;cellular process#GO:0009987 cytosol#GO:0005829;membrane#GO:0016020;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HUMAN|HGNC=20606|UniProtKB=Q13099 Q13099 IFT88 PTHR44117:SF2 INTRAFLAGELLAR TRANSPORT PROTEIN 88 HOMOLOG INTRAFLAGELLAR TRANSPORT PROTEIN 88 HOMOLOG protein binding#GO:0005515;binding#GO:0005488;cytoskeletal protein binding#GO:0008092 multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;animal organ development#GO:0048513;microtubule-based process#GO:0007017;neuron differentiation#GO:0030182;cellular component assembly#GO:0022607;nervous system development#GO:0007399;organelle organization#GO:0006996;kidney development#GO:0001822;neuron projection development#GO:0031175;cellular component biogenesis#GO:0044085;renal system development#GO:0072001;establishment of localization in cell#GO:0051649;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular localization#GO:0051641;cilium organization#GO:0044782;ear development#GO:0043583;neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;microtubule-based transport#GO:0099111;generation of neurons#GO:0048699;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell development#GO:0048468;inner ear receptor cell stereocilium organization#GO:0060122;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cellular developmental process#GO:0048869;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;neurogenesis#GO:0022008;plasma membrane bounded cell projection assembly#GO:0120031;sensory organ development#GO:0007423;intracellular transport#GO:0046907;developmental process#GO:0032502;transport#GO:0006810;multicellular organismal process#GO:0032501;cytoskeleton-dependent intracellular transport#GO:0030705;plasma membrane bounded cell projection organization#GO:0120036;inner ear development#GO:0048839;localization#GO:0051179;non-motile cilium assembly#GO:1905515;anatomical structure development#GO:0048856;system development#GO:0048731;organelle assembly#GO:0070925;microtubule-based movement#GO:0007018;intraciliary transport#GO:0042073 centriole#GO:0005814;intracellular membraneless organelle#GO:0043232;ciliary base#GO:0097546;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;intracellular anatomical structure#GO:0005622;non-motile cilium#GO:0097730;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cilium#GO:0005929 HUMAN|HGNC=12123|UniProtKB=A0A087WT03 A0A087WT03 TRAV26-1 PTHR19433:SF132 T-CELL RECEPTOR ALPHA CHAIN V REGION-RELATED T CELL RECEPTOR ALPHA VARIABLE 26-1 response to biotic stimulus#GO:0009607;response to bacterium#GO:0009617;response to stimulus#GO:0050896;response to external biotic stimulus#GO:0043207;response to external stimulus#GO:0009605;biological process involved in interspecies interaction between organisms#GO:0044419;response to other organism#GO:0051707 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=24836|UniProtKB=Q6ZVL6 Q6ZVL6 KIAA1549L PTHR21590:SF3 SEA DOMAIN-CONTAINING PROTEIN UPF0606 PROTEIN KIAA1549L HUMAN|HGNC=12106|UniProtKB=A0A075B6T6 A0A075B6T6 TRAV12-2 PTHR19343:SF3 T CELL RECEPTOR ALPHA VARIABLE 1-2 T CELL RECEPTOR ALPHA VARIABLE 12-2 peptide binding#GO:0042277;antigen binding#GO:0003823;binding#GO:0005488 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=7611|UniProtKB=P15172 P15172 MYOD1 PTHR11534:SF2 MYOGENIC FACTOR MYOBLAST DETERMINATION PROTEIN 1 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676 anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;muscle tissue development#GO:0060537;muscle structure development#GO:0061061;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of developmental process#GO:0050793;regulation of cell differentiation#GO:0045595;developmental process#GO:0032502;positive regulation of developmental process#GO:0051094;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of cell development#GO:0060284;skeletal muscle tissue development#GO:0007519;positive regulation of cellular process#GO:0048522;tissue development#GO:0009888;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;animal gross anatomical part developmental process#GO:0160108;skeletal muscle organ development#GO:0060538;positive regulation of multicellular organismal process#GO:0051240;regulation of biological process#GO:0050789;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;muscle organ development#GO:0007517;positive regulation of cell differentiation#GO:0045597;striated muscle tissue development#GO:0014706;animal organ development#GO:0048513;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;regulation of multicellular organismal process#GO:0051239;positive regulation of cell development#GO:0010720 intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=25176|UniProtKB=Q96MX6 Q96MX6 DNAAF10 PTHR10971:SF2 MRNA EXPORT FACTOR AND BUB3 DYNEIN AXONEMAL ASSEMBLY FACTOR 10 ubiquitin binding#GO:0043130;binding#GO:0005488;protein binding#GO:0005515 RNA metabolism protein#PC00031 HUMAN|HGNC=29436|UniProtKB=Q8WWB7 Q8WWB7 GLMP PTHR31981:SF1 GLYCOSYLATED LYSOSOMAL MEMBRANE PROTEIN GLYCOSYLATED LYSOSOMAL MEMBRANE PROTEIN intracellular organelle#GO:0043229;lytic vacuole#GO:0000323;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;lysosome#GO:0005764;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;vacuole#GO:0005773 HUMAN|HGNC=6178|UniProtKB=P23677 P23677 ITPKA PTHR12400:SF55 INOSITOL POLYPHOSPHATE KINASE INOSITOL-TRISPHOSPHATE 3-KINASE A phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740 small molecule metabolic process#GO:0044281;biosynthetic process#GO:0009058;phosphorus metabolic process#GO:0006793;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;alcohol biosynthetic process#GO:0046165;organophosphate biosynthetic process#GO:0090407;alcohol metabolic process#GO:0006066;metabolic process#GO:0008152;small molecule biosynthetic process#GO:0044283 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 kinase#PC00137 HUMAN|HGNC=30539|UniProtKB=Q8NEP3 Q8NEP3 DNAAF1 PTHR45973:SF19 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED DYNEIN AXONEMAL ASSEMBLY FACTOR 1 binding#GO:0005488;protein-containing complex binding#GO:0044877 cell projection organization#GO:0030030;cellular component organization#GO:0016043;cilium assembly#GO:0060271;determination of left/right symmetry#GO:0007368;anatomical structure development#GO:0048856;microtubule cytoskeleton organization#GO:0000226;cilium organization#GO:0044782;axoneme assembly#GO:0035082;organelle assembly#GO:0070925;microtubule bundle formation#GO:0001578;pattern specification process#GO:0007389;regionalization#GO:0003002;multicellular organismal process#GO:0032501;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;determination of bilateral symmetry#GO:0009855;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;microtubule-based process#GO:0007017;plasma membrane bounded cell projection assembly#GO:0120031;specification of symmetry#GO:0009799;left/right pattern formation#GO:0060972;developmental process#GO:0032502 cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;ciliary plasm#GO:0097014;organelle#GO:0043226;intracellular organelle#GO:0043229;cilium#GO:0005929;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;axoneme#GO:0005930 protein-binding activity modulator#PC00095;phosphatase modulator#PC00184 HUMAN|HGNC=21744|UniProtKB=Q9BZB8 Q9BZB8 CPEB1 PTHR12566:SF9 CYTOPLASMIC POLYADENYLATION ELEMENT BINDING PROTEIN CPEB CYTOPLASMIC POLYADENYLATION ELEMENT-BINDING PROTEIN 1 ribonucleoprotein complex binding#GO:0043021;RNA binding#GO:0003723;protein-containing complex binding#GO:0044877;ribosome binding#GO:0043022;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;translation regulator activity#GO:0045182;mRNA 3'-UTR binding#GO:0003730;translation factor activity#GO:0180051 negative regulation of translation#GO:0017148;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of protein metabolic process#GO:0051246;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890 cell projection#GO:0042995;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;synapse#GO:0045202;neuron projection#GO:0043005;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cell junction#GO:0030054;intracellular organelle#GO:0043229 mRNA polyadenylation factor#PC00146 HUMAN|HGNC=24100|UniProtKB=Q6NTF7 Q6NTF7 APOBEC3H PTHR13857:SF43 MRNA EDITING ENZYME DNA DC-DU-EDITING ENZYME APOBEC-3H hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;deaminase activity#GO:0019239;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;catalytic activity#GO:0003824;RNA binding#GO:0003723;hydrolase activity#GO:0016787;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;response to external biotic stimulus#GO:0043207;cytidine to uridine editing#GO:0016554;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;response to virus#GO:0009615;macromolecule modification#GO:0043412;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;response to other organism#GO:0051707;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;response to external stimulus#GO:0009605;defense response#GO:0006952;negative regulation of cellular process#GO:0048523;response to stimulus#GO:0050896;negative regulation of metabolic process#GO:0009892;biological process involved in interspecies interaction between organisms#GO:0044419;negative regulation of biological process#GO:0048519;defense response to virus#GO:0051607;regulation of biological process#GO:0050789;RNA metabolic process#GO:0016070;base conversion or substitution editing#GO:0016553;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;RNA modification#GO:0009451;negative regulation of macromolecule biosynthetic process#GO:0010558;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;cellular process#GO:0009987;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253 P-body#GO:0000932;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;ribonucleoprotein granule#GO:0035770;organelle#GO:0043226;supramolecular complex#GO:0099080;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 RNA processing factor#PC00147 HUMAN|HGNC=24970|UniProtKB=Q0D2I5 Q0D2I5 IFFO1 PTHR14516:SF2 1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE FAMILY MEMBER NON-HOMOLOGOUS END JOINING FACTOR IFFO1 oxidoreductase#PC00176;dehydrogenase#PC00092 HUMAN|HGNC=21199|UniProtKB=Q96AQ6 Q96AQ6 PBXIP1 PTHR28638:SF1 CELL CYCLE PROGRESSION PROTEIN 1 PRE-B-CELL LEUKEMIA TRANSCRIPTION FACTOR-INTERACTING PROTEIN 1 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=33116|UniProtKB=Q1MX18 Q1MX18 INSC PTHR21386:SF0 INSCUTEABLE PROTEIN INSCUTEABLE HOMOLOG cytoskeletal adaptor activity#GO:0008093;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 regulation of cellular process#GO:0050794;localization#GO:0051179;biological regulation#GO:0065007;intracellular protein localization#GO:0008104;regulation of cell division#GO:0051302;macromolecule localization#GO:0033036;regulation of biological process#GO:0050789 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cell cortex#GO:0005938;cell periphery#GO:0071944 HUMAN|HGNC=66|UniProtKB=Q9UBJ2 Q9UBJ2 ABCD2 PTHR11384:SF24 ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 2 carboxylic acid transmembrane transporter activity#GO:0046943;anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167;primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804;monocarboxylic acid transmembrane transporter activity#GO:0008028;nucleotide binding#GO:0000166;transmembrane transporter activity#GO:0022857;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP binding#GO:0005524;binding#GO:0005488;nucleoside phosphate binding#GO:1901265;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;ribonucleotide binding#GO:0032553;transporter activity#GO:0005215;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;carbohydrate derivative binding#GO:0097367 lipid catabolic process#GO:0016042;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle organization#GO:0006996;fatty acid oxidation#GO:0019395;carboxylic acid transport#GO:0046942;organic acid transport#GO:0015849;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;cellular component organization#GO:0016043;very long-chain fatty acid metabolic process#GO:0000038;small molecule catabolic process#GO:0044282;small molecule metabolic process#GO:0044281;peroxisome organization#GO:0007031;oxoacid metabolic process#GO:0043436;lipid localization#GO:0010876;fatty acid catabolic process#GO:0009062;cellular localization#GO:0051641;transmembrane transport#GO:0055085;carboxylic acid catabolic process#GO:0046395;macromolecule localization#GO:0033036;lipid transport#GO:0006869;monocarboxylic acid catabolic process#GO:0072329;transport#GO:0006810;fatty acid beta-oxidation#GO:0006635;lipid metabolic process#GO:0006629;fatty acid metabolic process#GO:0006631;intracellular transport#GO:0046907;lipid modification#GO:0030258;establishment of localization#GO:0051234;primary metabolic process#GO:0044238;carboxylic acid transmembrane transport#GO:1905039;catabolic process#GO:0009056;monocarboxylic acid transport#GO:0015718;peroxisomal transport#GO:0043574;fatty acid transport#GO:0015908;localization#GO:0051179;lipid oxidation#GO:0034440 microbody#GO:0042579;peroxisome#GO:0005777;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;peroxisomal membrane#GO:0005778;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622 ATP-binding cassette (ABC) transporter#PC00003;primary active transporter#PC00068 HUMAN|HGNC=18259|UniProtKB=Q8WWA0 Q8WWA0 ITLN1 PTHR16146:SF38 INTELECTIN INTELECTIN-1 binding#GO:0005488;oligosaccharide binding#GO:0070492;carbohydrate binding#GO:0030246 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=25286|UniProtKB=Q8TC99 Q8TC99 FNDC8 PTHR32430:SF1 FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN 8 FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN 8 HUMAN|HGNC=8185|UniProtKB=P47884 P47884 OR1D4 PTHR48001:SF70 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 1D4-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cell communication#GO:0007154 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=22036|UniProtKB=Q8N8F7 Q8N8F7 LSMEM1 PTHR36475:SF1 LEUCINE-RICH SINGLE-PASS MEMBRANE PROTEIN 1 LEUCINE-RICH SINGLE-PASS MEMBRANE PROTEIN 1 HUMAN|HGNC=24268|UniProtKB=Q8N9N2 Q8N9N2 ASCC1 PTHR13360:SF1 ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1 ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=12957|UniProtKB=Q14929 Q14929 ZNF169 PTHR24381:SF25 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 169 binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=17944|UniProtKB=Q9NQT5 Q9NQT5 EXOSC3 PTHR21321:SF1 PNAS-3 RELATED EXOSOME COMPLEX COMPONENT RRP40 nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 snRNA processing#GO:0016180;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;rRNA metabolic process#GO:0016072;negative regulation of cellular process#GO:0048523;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;biosynthetic process#GO:0009058;negative regulation of macromolecule metabolic process#GO:0010605;macromolecule biosynthetic process#GO:0009059;nucleic acid catabolic process#GO:0141188;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;rRNA processing#GO:0006364;snRNA metabolic process#GO:0016073;RNA biosynthetic process#GO:0032774;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;RNA 3'-end processing#GO:0031123;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;macromolecule catabolic process#GO:0009057;RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA catabolic process#GO:0006401;ribosome biogenesis#GO:0042254;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;maturation of 5.8S rRNA#GO:0000460;snRNA 3'-end processing#GO:0034472;ribonucleoprotein complex biogenesis#GO:0022613;regulation of biological process#GO:0050789;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974 RNA processing factor#PC00147 HUMAN|HGNC=9761|UniProtKB=Q15907 Q15907 RAB11B PTHR47979:SF41 DRAB11-RELATED RAS-RELATED PROTEIN RAB-11B catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;anion binding#GO:0043168;ion binding#GO:0043167;GTPase activity#GO:0003924;hydrolase activity#GO:0016787;ribonucleotide binding#GO:0032553;hydrolase activity, acting on acid anhydrides#GO:0016817;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;guanyl nucleotide binding#GO:0019001;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;nucleoside phosphate binding#GO:1901265;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561 export from cell#GO:0140352;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;exocytosis#GO:0006887;secretion by cell#GO:0032940;establishment of localization#GO:0051234;secretion#GO:0046903;localization#GO:0051179;transport#GO:0006810;regulated exocytosis#GO:0045055 intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;recycling endosome#GO:0055037;intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622 G-protein#PC00020;small GTPase#PC00208 PDGF signaling pathway#P00047>Ras#P01154 HUMAN|HGNC=16656|UniProtKB=Q9GZX5 Q9GZX5 ZNF350 PTHR24404:SF134 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 350 binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244;DNA-binding transcription factor#PC00218 HUMAN|HGNC=4834|UniProtKB=Q9Y450 Q9Y450 HBS1L PTHR23115:SF188 TRANSLATION FACTOR HBS1-LIKE PROTEIN pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111 translation#GO:0006412;protein metabolic process#GO:0019538;cellular component disassembly#GO:0022411;organelle disassembly#GO:1903008;rescue of stalled cytosolic ribosome#GO:0072344;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;protein biosynthetic process#GO:0160307;cytoplasmic translation#GO:0002181;translational elongation#GO:0006414;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;organelle organization#GO:0006996;biosynthetic process#GO:0009058;gene expression#GO:0010467 translation factor#PC00223 HUMAN|HGNC=12009|UniProtKB=P60174 P60174 TPI1 PTHR21139:SF24 TRIOSEPHOSPHATE ISOMERASE TRIOSEPHOSPHATE ISOMERASE intramolecular oxidoreductase activity#GO:0016860;isomerase activity#GO:0016853;catalytic activity#GO:0003824;intramolecular oxidoreductase activity, interconverting aldoses and ketoses#GO:0016861 ADP metabolic process#GO:0046031;purine ribonucleoside diphosphate metabolic process#GO:0009179;generation of precursor metabolites and energy#GO:0006091;biosynthetic process#GO:0009058;monosaccharide biosynthetic process#GO:0046364;organophosphate metabolic process#GO:0019637;purine ribonucleoside triphosphate metabolic process#GO:0009205;glycolytic process#GO:0006096;purine ribonucleoside diphosphate catabolic process#GO:0009181;aerobic respiration#GO:0009060;nucleoside diphosphate metabolic process#GO:0009132;pyridine-containing compound metabolic process#GO:0072524;nucleoside phosphate catabolic process#GO:1901292;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate derivative catabolic process#GO:1901136;hexose metabolic process#GO:0019318;primary metabolic process#GO:0044238;purine nucleoside triphosphate metabolic process#GO:0009144;purine nucleoside diphosphate catabolic process#GO:0009137;nucleobase-containing small molecule metabolic process#GO:0055086;ADP catabolic process#GO:0046032;carbohydrate biosynthetic process#GO:0016051;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;nucleotide metabolic process#GO:0009117;carbohydrate catabolic process#GO:0016052;ribonucleotide metabolic process#GO:0009259;purine nucleoside diphosphate metabolic process#GO:0009135;pyruvate metabolic process#GO:0006090;monocarboxylic acid metabolic process#GO:0032787;pyridine-containing compound catabolic process#GO:0072526;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;energy derivation by oxidation of organic compounds#GO:0015980;nucleotide catabolic process#GO:0009166;small molecule biosynthetic process#GO:0044283;nucleobase-containing compound metabolic process#GO:0006139;nucleobase-containing compound catabolic process#GO:0034655;ribonucleotide catabolic process#GO:0009261;carbohydrate derivative metabolic process#GO:1901135;cellular respiration#GO:0045333;organophosphate biosynthetic process#GO:0090407;ribonucleoside diphosphate catabolic process#GO:0009191;organophosphate catabolic process#GO:0046434;purine nucleotide catabolic process#GO:0006195;catabolic process#GO:0009056;nucleoside phosphate metabolic process#GO:0006753;carbohydrate metabolic process#GO:0005975;nucleoside diphosphate catabolic process#GO:0009134;purine ribonucleotide catabolic process#GO:0009154;hexose biosynthetic process#GO:0019319;carbohydrate derivative biosynthetic process#GO:1901137;glucose metabolic process#GO:0006006;purine-containing compound catabolic process#GO:0072523;monosaccharide metabolic process#GO:0005996;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;ATP metabolic process#GO:0046034;aldehyde metabolic process#GO:0006081;gluconeogenesis#GO:0006094;nicotinamide nucleotide metabolic process#GO:0046496;oxoacid metabolic process#GO:0043436;glyceraldehyde-3-phosphate metabolic process#GO:0019682;small molecule metabolic process#GO:0044281;pyridine nucleotide catabolic process#GO:0019364;phosphorus metabolic process#GO:0006793;carboxylic acid metabolic process#GO:0019752;ribonucleoside diphosphate metabolic process#GO:0009185 isomerase#PC00135;metabolite interconversion enzyme#PC00262 Glycolysis#P00024>Triosephosphate isomerase#P00673 HUMAN|HGNC=28510|UniProtKB=Q8NEA6 Q8NEA6 GLIS3 PTHR45718:SF1 TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS ZINC FINGER PROTEIN GLIS3 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HUMAN|HGNC=25749|UniProtKB=Q9C0B7 Q9C0B7 TANGO6 PTHR20959:SF1 TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 FAMILY MEMBER TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 HOMOLOG establishment of localization#GO:0051234;secretion#GO:0046903;localization#GO:0051179;protein secretion#GO:0009306;protein transport#GO:0015031;establishment of protein localization to extracellular region#GO:0035592;secretion by cell#GO:0032940;intracellular protein localization#GO:0008104;transport#GO:0006810;export from cell#GO:0140352;macromolecule localization#GO:0033036;cellular process#GO:0009987;protein localization to extracellular region#GO:0071692;establishment of protein localization#GO:0045184 HUMAN|HGNC=30611|UniProtKB=Q8TCJ2 Q8TCJ2 STT3B PTHR13872:SF49 DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3B catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758;glycosyltransferase activity#GO:0016757 macromolecule metabolic process#GO:0043170;macromolecule modification#GO:0043412;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;biosynthetic process#GO:0009058;post-translational protein modification#GO:0043687;glycoprotein biosynthetic process#GO:0009101;protein modification process#GO:0036211;protein N-linked glycosylation#GO:0006487;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 endoplasmic reticulum protein-containing complex#GO:0140534;organelle membrane#GO:0031090;transferase complex#GO:1990234;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;endoplasmic reticulum subcompartment#GO:0098827;oligosaccharyltransferase complex#GO:0008250;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane protein complex#GO:0098796 glycosyltransferase#PC00111 HUMAN|HGNC=20448|UniProtKB=A6NKN8 A6NKN8 PCP4L1 PTHR15359:SF5 IG-LIKE DOMAIN-CONTAINING PROTEIN PURKINJE CELL PROTEIN 4-LIKE PROTEIN 1 HUMAN|HGNC=1476|UniProtKB=P07384 P07384 CAPN1 PTHR10183:SF284 CALPAIN CALPAIN-1 CATALYTIC SUBUNIT cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;cysteine-type endopeptidase activity#GO:0004197;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;proteolysis#GO:0006508;primary metabolic process#GO:0044238;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 cysteine protease#PC00081;protease#PC00190 Huntington disease#P00029>Calpain#P00788 HUMAN|HGNC=16008|UniProtKB=Q9BYV2 Q9BYV2 TRIM54 PTHR24103:SF596 E3 UBIQUITIN-PROTEIN LIGASE TRIM TRIPARTITE MOTIF-CONTAINING PROTEIN 54 acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 immune system process#GO:0002376;response to external stimulus#GO:0009605;defense response#GO:0006952;innate immune response#GO:0045087;immune response#GO:0006955;defense response to symbiont#GO:0140546;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to other organism#GO:0051707;response to stimulus#GO:0050896;defense response to other organism#GO:0098542 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=4287|UniProtKB=O95377 O95377 GJB5 PTHR11984:SF29 CONNEXIN GAP JUNCTION BETA-5 PROTEIN wide pore channel activity#GO:0022829;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 signaling#GO:0023052;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;cell communication#GO:0007154;regulation of biological process#GO:0050789;cellular process#GO:0009987 anchoring junction#GO:0070161;cell junction#GO:0030054;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;cell-cell junction#GO:0005911;membrane#GO:0016020;membrane protein complex#GO:0098796 gap junction#PC00105;cell junction protein#PC00070 HUMAN|HGNC=26848|UniProtKB=Q8N808 Q8N808 SLC35G3 PTHR22911:SF110 ACYL-MALONYL CONDENSING ENZYME-RELATED SOLUTE CARRIER FAMILY 35 MEMBER G3-RELATED cellular anatomical structure#GO:0110165;membrane#GO:0016020 transporter#PC00227 HUMAN|HGNC=14923|UniProtKB=O60883 O60883 GPR37L1 PTHR46216:SF4 PROSAPOSIN RECEPTOR GPR37 FAMILY MEMBER G PROTEIN-COUPLED RECEPTOR 37-LIKE 1 transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;molecular transducer activity#GO:0060089 positive regulation of response to stimulus#GO:0048584;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165;positive regulation of MAPK cascade#GO:0043410;adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway#GO:0007193;regulation of response to stimulus#GO:0048583;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;positive regulation of intracellular signal transduction#GO:1902533;regulation of MAPK cascade#GO:0043408;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of cell communication#GO:0010646;signaling#GO:0023052;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;positive regulation of signaling#GO:0023056;cell communication#GO:0007154;regulation of intracellular signal transduction#GO:1902531;G protein-coupled receptor signaling pathway#GO:0007186;regulation of signaling#GO:0023051 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;signaling receptor complex#GO:0043235 G-protein coupled receptor#PC00021 Parkinson disease#P00049>Pael-R#P01229 HUMAN|HGNC=16939|UniProtKB=O95391 O95391 SLU7 PTHR12942:SF2 STEP II SPLICING FACTOR SLU7 PRE-MRNA-SPLICING FACTOR SLU7 pre-mRNA binding#GO:0036002;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;mRNA cis splicing, via spliceosome#GO:0045292;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398 intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 RNA processing factor#PC00147;RNA splicing factor#PC00148 HUMAN|HGNC=25229|UniProtKB=Q9NU23 Q9NU23 LYRM2 PTHR13675:SF3 LYR MOTIF-CONTAINING PROTEIN 2 LYR MOTIF-CONTAINING PROTEIN 2 mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=6090|UniProtKB=Q01101 Q01101 INSM1 PTHR15065:SF5 INSULINOMA-ASSOCIATED 1 INSULINOMA-ASSOCIATED PROTEIN 1 sequence-specific DNA binding#GO:0043565;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription repressor activity#GO:0001217;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;negative regulation of metabolic process#GO:0009892;regulation of cell cycle#GO:0051726;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;multicellular organism development#GO:0007275;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;neuron differentiation#GO:0030182;nervous system development#GO:0007399;regulation of cell cycle process#GO:0010564;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;transcription repressor complex#GO:0017053;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 HUMAN|HGNC=4280|UniProtKB=P36383 P36383 GJC1 PTHR11984:SF6 CONNEXIN GAP JUNCTION GAMMA-1 PROTEIN transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;channel activity#GO:0015267;wide pore channel activity#GO:0022829 regulation of biological process#GO:0050789;cellular process#GO:0009987;signaling#GO:0023052;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;cell communication#GO:0007154 plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;cell-cell junction#GO:0005911;membrane#GO:0016020;membrane protein complex#GO:0098796;anchoring junction#GO:0070161;cell junction#GO:0030054 cell junction protein#PC00070;gap junction#PC00105 HUMAN|HGNC=28531|UniProtKB=Q2T9J0 Q2T9J0 TYSND1 PTHR21004:SF0 SERINE PROTEASE-RELATED PEROXISOMAL LEADER PEPTIDE-PROCESSING PROTEASE serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;serine-type peptidase activity#GO:0008236;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;catalytic activity#GO:0003824 protein metabolic process#GO:0019538;proteolysis#GO:0006508;regulation of lipid metabolic process#GO:0019216;regulation of cellular process#GO:0050794;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;regulation of lipid catabolic process#GO:0050994;macromolecule metabolic process#GO:0043170;regulation of catabolic process#GO:0009894;metabolic process#GO:0008152;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;macromolecule biosynthetic process#GO:0009059;protein processing#GO:0016485;cellular process#GO:0009987 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microbody#GO:0042579;peroxisome#GO:0005777 serine protease#PC00203 HUMAN|HGNC=4116|UniProtKB=Q14376 Q14376 GALE PTHR43725:SF58 UDP-GLUCOSE 4-EPIMERASE UDP-GLUCOSE 4-EPIMERASE isomerase activity#GO:0016853;racemase and epimerase activity#GO:0016854;racemase and epimerase activity, acting on carbohydrates and derivatives#GO:0016857;catalytic activity#GO:0003824 metabolic process#GO:0008152;monosaccharide metabolic process#GO:0005996;carbohydrate catabolic process#GO:0016052;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;phosphorus metabolic process#GO:0006793;hexose metabolic process#GO:0019318;primary metabolic process#GO:0044238;carbohydrate metabolic process#GO:0005975;small molecule catabolic process#GO:0044282;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 epimerase/racemase#PC00096 Fructose galactose metabolism#P02744>UDP Glucose 4 epimerase#P02965 HUMAN|HGNC=24134|UniProtKB=Q8WYQ9 Q8WYQ9 ZCCHC14 PTHR16195:SF16 ZINC FINGER CCHC DOMAIN CONTAINING PROTEIN ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 14 HUMAN|HGNC=21014|UniProtKB=Q9H6X2 Q9H6X2 ANTXR1 PTHR16059:SF11 ANTHRAX TOXIN RECEPTOR ANTHRAX TOXIN RECEPTOR 1 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cell surface#GO:0009986;cellular anatomical structure#GO:0110165 cell adhesion molecule#PC00069 HUMAN|HGNC=3344|UniProtKB=Q9NRM1 Q9NRM1 ENAM PTHR16784:SF2 ENAMELIN ENAMELIN extracellular matrix structural constituent#GO:0005201;structural molecule activity#GO:0005198 anatomical structure development#GO:0048856;animal gross anatomical part developmental process#GO:0160108;animal organ morphogenesis#GO:0009887;cell differentiation#GO:0030154;odontogenesis#GO:0042476;regulation of developmental process#GO:0050793;regulation of multicellular organismal development#GO:2000026;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cellular developmental process#GO:0048869;animal organ development#GO:0048513;anatomical structure formation involved in morphogenesis#GO:0048646;developmental process#GO:0032502;positive regulation of developmental process#GO:0051094;epithelial cell differentiation#GO:0030855;tissue development#GO:0009888;odontogenesis of dentin-containing tooth#GO:0042475;epithelium development#GO:0060429;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;amelogenesis#GO:0097186;cellular process#GO:0009987;positive regulation of biological process#GO:0048518 extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cellular anatomical structure#GO:0110165 structural protein#PC00211 HUMAN|HGNC=17844|UniProtKB=Q8N4N3 Q8N4N3 KLHL36 PTHR45632:SF4 LD33804P KELCH-LIKE PROTEIN 36 protein binding#GO:0005515;ubiquitin-like ligase-substrate adaptor activity#GO:1990756;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;enzyme-substrate adaptor activity#GO:0140767 ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238 catalytic complex#GO:1902494;transferase complex#GO:1990234;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535;Cul3-RING ubiquitin ligase complex#GO:0031463;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151 scaffold/adaptor protein#PC00226 HUMAN|Gene=YF016_HUMAN|UniProtKB=A6NL46 A6NL46 PTHR15566:SF10 POM121-LIKE UPF0607 PROTEIN ENSP00000332738-RELATED HUMAN|HGNC=602|UniProtKB=P06727 P06727 APOA4 PTHR18976:SF1 APOLIPOPROTEIN APOLIPOPROTEIN A-IV molecular carrier activity#GO:0140104;lipid carrier activity#GO:0005319;binding#GO:0005488;enzyme regulator activity#GO:0030234;lipid binding#GO:0008289;lipid transfer activity#GO:0120013;molecular function activator activity#GO:0140677;enzyme activator activity#GO:0008047;phospholipid binding#GO:0005543;transporter activity#GO:0005215;sterol transfer activity#GO:0120015;molecular function regulator activity#GO:0098772;cholesterol transfer activity#GO:0120020 macromolecule localization#GO:0033036;cholesterol transport#GO:0030301;cellular process#GO:0009987;cholesterol efflux#GO:0033344;lipid transport#GO:0006869;phospholipid transport#GO:0015914;steroid metabolic process#GO:0008202;metabolic process#GO:0008152;alcohol metabolic process#GO:0006066;cholesterol metabolic process#GO:0008203;transport#GO:0006810;lipid metabolic process#GO:0006629;chemical homeostasis#GO:0048878;sterol metabolic process#GO:0016125;establishment of localization#GO:0051234;sterol transport#GO:0015918;lipid homeostasis#GO:0055088;primary metabolic process#GO:0044238;small molecule metabolic process#GO:0044281;organophosphate ester transport#GO:0015748;secondary alcohol metabolic process#GO:1902652;homeostatic process#GO:0042592;lipid localization#GO:0010876;localization#GO:0051179;organic hydroxy compound transport#GO:0015850 organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;vesicle#GO:0031982;very-low-density lipoprotein particle#GO:0034361;high-density lipoprotein particle#GO:0034364;membrane-bounded organelle#GO:0043227;plasma lipoprotein particle#GO:0034358;lipoprotein particle#GO:1990777;protein-lipid complex#GO:0032994;extracellular protein-containing complex#GO:0140392;extracellular region#GO:0005576 apolipoprotein#PC00052;transfer/carrier protein#PC00219 HUMAN|HGNC=7666|UniProtKB=Q9Y2A7 Q9Y2A7 NCKAP1 PTHR12093:SF11 NCK-ASSOCIATED PROTEIN 1 NCK-ASSOCIATED PROTEIN 1 plasma membrane bounded cell projection organization#GO:0120036;multicellular organismal process#GO:0032501;cell migration#GO:0016477;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;cell motility#GO:0048870;actin cytoskeleton organization#GO:0030036;system development#GO:0048731;anatomical structure development#GO:0048856;cortical actin cytoskeleton organization#GO:0030866;actin filament-based process#GO:0030029;cortical cytoskeleton organization#GO:0030865;nervous system development#GO:0007399;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component biogenesis#GO:0044085;neuron projection development#GO:0031175;organelle organization#GO:0006996;cell projection morphogenesis#GO:0048858;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;cell development#GO:0048468;cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;cell differentiation#GO:0030154;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;neuron development#GO:0048666;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 HUMAN|HGNC=4208|UniProtKB=P23434 P23434 GCSH PTHR11715:SF42 GLYCINE CLEAVAGE SYSTEM H PROTEIN GLYCINE CLEAVAGE SYSTEM H PROTEIN, MITOCHONDRIAL carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;proteinogenic amino acid metabolic process#GO:0170039;small molecule catabolic process#GO:0044282;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;oxidoreductase complex#GO:1990204 HUMAN|HGNC=16158|UniProtKB=Q9BR10 Q9BR10 SPATA25 PTHR36857:SF1 SPERMATOGENESIS-ASSOCIATED PROTEIN 25 SPERMATOGENESIS-ASSOCIATED PROTEIN 25 multicellular organismal reproductive process#GO:0048609;spermatogenesis#GO:0007283;developmental process#GO:0032502;sexual reproduction#GO:0019953;gamete generation#GO:0007276;male gamete generation#GO:0048232;reproductive process#GO:0022414;developmental process involved in reproduction#GO:0003006 HUMAN|HGNC=16711|UniProtKB=Q9Y2C9 Q9Y2C9 TLR6 PTHR24365:SF422 TOLL-LIKE RECEPTOR TOLL-LIKE RECEPTOR 6 signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;lipid binding#GO:0008289 cell communication#GO:0007154;response to bacterium#GO:0009617;regulation of immune response#GO:0050776;regulation of defense response#GO:0031347;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;response to external biotic stimulus#GO:0043207;regulation of response to biotic stimulus#GO:0002831;innate immune response-activating signaling pathway#GO:0002758;cellular response to biotic stimulus#GO:0071216;cellular response to stimulus#GO:0051716;regulation of innate immune response#GO:0045088;cellular response to molecule of bacterial origin#GO:0071219;positive regulation of response to biotic stimulus#GO:0002833;response to external stimulus#GO:0009605;pattern recognition receptor signaling pathway#GO:0002221;regulation of response to stress#GO:0080134;positive regulation of defense response#GO:0031349;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;response to other organism#GO:0051707;activation of innate immune response#GO:0002218;positive regulation of innate immune response#GO:0045089;immune system process#GO:0002376;response to stimulus#GO:0050896;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;toll-like receptor signaling pathway#GO:0002224;response to molecule of bacterial origin#GO:0002237;regulation of biological process#GO:0050789;immune response-regulating signaling pathway#GO:0002764;immune response-activating signaling pathway#GO:0002757;positive regulation of response to external stimulus#GO:0032103;regulation of response to external stimulus#GO:0032101;response to biotic stimulus#GO:0009607;positive regulation of immune system process#GO:0002684;activation of immune response#GO:0002253;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987 signaling receptor complex#GO:0043235;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 Toll receptor signaling pathway#P00054>TLR1,2,6#P01380;Toll receptor signaling pathway#P00054>TLR#P01346 HUMAN|HGNC=26752|UniProtKB=Q8N9B4 Q8N9B4 ANKRD42 PTHR24201:SF2 ANK_REP_REGION DOMAIN-CONTAINING PROTEIN ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 42 RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629;protein binding#GO:0005515;DNA-binding transcription factor binding#GO:0140297;transcription factor binding#GO:0008134;binding#GO:0005488 protein-binding activity modulator#PC00095;kinase inhibitor#PC00139 HUMAN|HGNC=6080|UniProtKB=O15357 O15357 INPPL1 PTHR46051:SF2 SH2 DOMAIN-CONTAINING PROTEIN PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2 phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578 regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;negative regulation of signal transduction#GO:0009968;negative regulation of response to stimulus#GO:0048585;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of cell communication#GO:0010648;regulation of immune response#GO:0050776;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;negative regulation of cellular process#GO:0048523 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 PI3 kinase pathway#P00048>SHIP#P01200;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>SHIP#P00839;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>SHIP2#P00897 HUMAN|HGNC=19297|UniProtKB=Q07912 Q07912 TNK2 PTHR24418:SF384 TYROSINE-PROTEIN KINASE ACTIVATED CDC42 KINASE 1 catalytic activity, acting on a protein#GO:0140096;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 non-receptor tyrosine protein kinase#PC00168 HUMAN|HGNC=7221|UniProtKB=Q13368 Q13368 MPP3 PTHR23122:SF33 MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK MAGUK P55 SUBFAMILY MEMBER 3 plasma membrane#GO:0005886;anchoring junction#GO:0070161;cell junction#GO:0030054;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;cell-cell junction#GO:0005911;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HUMAN|HGNC=33905|UniProtKB=A5A3E0 A5A3E0 POTEF PTHR11937:SF547 ACTIN POTE ANKYRIN DOMAIN FAMILY MEMBER E-RELATED structural constituent of synapse#GO:0098918;protein binding#GO:0005515;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;structural constituent of cytoskeleton#GO:0005200;binding#GO:0005488;kinase binding#GO:0019900;structural molecule activity#GO:0005198 system development#GO:0048731;neuron development#GO:0048666;axonogenesis#GO:0007409;anatomical structure development#GO:0048856;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell motility#GO:0048870;cell morphogenesis#GO:0000902;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;cell projection morphogenesis#GO:0048858;neurogenesis#GO:0022008;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;developmental process#GO:0032502;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron projection morphogenesis#GO:0048812;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;plasma membrane bounded cell projection organization#GO:0120036;multicellular organismal process#GO:0032501;cellular process#GO:0009987;neuron projection development#GO:0031175;axon development#GO:0061564 intracellular organelle#GO:0043229;protein acetyltransferase complex#GO:0031248;acetyltransferase complex#GO:1902493;supramolecular fiber#GO:0099512;actin cytoskeleton#GO:0015629;organelle#GO:0043226;cellular anatomical structure#GO:0110165;synapse#GO:0045202;cell projection#GO:0042995;actin filament#GO:0005884;cell junction#GO:0030054;histone acetyltransferase complex#GO:0000123;neuron projection#GO:0043005;chromatin#GO:0000785;NuA4 histone acetyltransferase complex#GO:0035267;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;catalytic complex#GO:1902494;axon#GO:0030424;intracellular anatomical structure#GO:0005622;chromosome#GO:0005694;plasma membrane bounded cell projection#GO:0120025;cytoskeleton#GO:0005856;transferase complex#GO:1990234;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;intracellular protein-containing complex#GO:0140535;membrane#GO:0016020;H4 histone acetyltransferase complex#GO:1902562 actin and actin related protein#PC00039 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>F-actin#P00858;Alzheimer disease-presenilin pathway#P00004>actin#P00114;Nicotinic acetylcholine receptor signaling pathway#P00044>Actin#P01090;Cytoskeletal regulation by Rho GTPase#P00016>Actin#P00512;Cadherin signaling pathway#P00012>F-actin#P00470;Huntington disease#P00029>Actin#P00807;Integrin signalling pathway#P00034>Actin#P00944 HUMAN|HGNC=2260|UniProtKB=Q12887 Q12887 COX10 PTHR43448:SF2 PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;prenyltransferase activity#GO:0004659 porphyrin-containing compound biosynthetic process#GO:0006779;porphyrin-containing compound metabolic process#GO:0006778;pigment biosynthetic process#GO:0046148;tetrapyrrole metabolic process#GO:0033013;metabolic process#GO:0008152;heme metabolic process#GO:0042168;biosynthetic process#GO:0009058;tetrapyrrole biosynthetic process#GO:0033014;cellular process#GO:0009987;pigment metabolic process#GO:0042440;heme biosynthetic process#GO:0006783 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739 metabolite interconversion enzyme#PC00262;transferase#PC00220;acyltransferase#PC00042 Heme biosynthesis#P02746>Protoheme IX farnesyl transferase#P02982 HUMAN|HGNC=5139|UniProtKB=P13378 P13378 HOXD8 PTHR46166:SF1 HOMEOBOX DOMAIN-CONTAINING PROTEIN HOMEOBOX PROTEIN HOX-D8 DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 homeodomain transcription factor#PC00119 HUMAN|HGNC=10870|UniProtKB=Q92186 Q92186 ST8SIA2 PTHR11987:SF30 ALPHA-2,8-SIALYLTRANSFERASE ALPHA-2,8-SIALYLTRANSFERASE 8B sialyltransferase activity#GO:0008373;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;transferase activity#GO:0016740 biosynthetic process#GO:0009058;carbohydrate metabolic process#GO:0005975;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487;glycoprotein biosynthetic process#GO:0009101;oligosaccharide metabolic process#GO:0009311;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152 metabolite interconversion enzyme#PC00262;transferase#PC00220 HUMAN|HGNC=29204|UniProtKB=Q8N300 Q8N300 SVBP PTHR34762:SF1 SMALL VASOHIBIN-BINDING PROTEIN SMALL VASOHIBIN-BINDING PROTEIN biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;macromolecule localization#GO:0033036;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;establishment of protein localization#GO:0045184;establishment of localization#GO:0051234;establishment of protein localization to extracellular region#GO:0035592;intracellular protein localization#GO:0008104;regulation of protein modification process#GO:0031399;negative regulation of cellular process#GO:0048523;transport#GO:0006810;regulation of protein ubiquitination#GO:0031396;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of protein metabolic process#GO:0051248;export from cell#GO:0140352;negative regulation of metabolic process#GO:0009892;regulation of protein modification by small protein conjugation or removal#GO:1903320;negative regulation of biological process#GO:0048519;protein localization to extracellular region#GO:0071692;regulation of biological process#GO:0050789;secretion#GO:0046903;localization#GO:0051179;protein secretion#GO:0009306;regulation of post-translational protein modification#GO:1901873;protein transport#GO:0015031;secretion by cell#GO:0032940;negative regulation of protein ubiquitination#GO:0031397 apical part of cell#GO:0045177;cellular anatomical structure#GO:0110165 HUMAN|HGNC=15964|UniProtKB=Q13117 Q13117 DAZ2 PTHR11176:SF8 BOULE-RELATED DELETED IN AZOOSPERMIA PROTEIN 1-RELATED translation regulator activity#GO:0045182 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;negative regulation of RNA catabolic process#GO:1902369;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;positive regulation of gene expression#GO:0010628;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA stability#GO:0043487;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;negative regulation of catabolic process#GO:0009895;positive regulation of translation#GO:0045727;regulation of protein metabolic process#GO:0051246;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604;mRNA stabilization#GO:0048255;negative regulation of RNA metabolic process#GO:0051253;regulation of mRNA metabolic process#GO:1903311;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;regulation of biological process#GO:0050789;regulation of mRNA stability#GO:0043488;negative regulation of metabolic process#GO:0009892;positive regulation of protein metabolic process#GO:0051247;regulation of translational initiation#GO:0006446;RNA stabilization#GO:0043489;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of biological quality#GO:0065008;negative regulation of nucleobase-containing compound metabolic process#GO:0045934 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HUMAN|HGNC=9765|UniProtKB=Q969Q5 Q969Q5 RAB24 PTHR24073:SF471 DRAB5-RELATED RAS-RELATED PROTEIN RAB-24 ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824 intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;protein transport#GO:0015031;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184 autophagosome#GO:0005776;endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;endocytic vesicle#GO:0030139;membrane-bounded organelle#GO:0043227;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;vacuole#GO:0005773 G-protein#PC00020;small GTPase#PC00208 HUMAN|HGNC=30384|UniProtKB=Q9UMX5 Q9UMX5 NENF PTHR10281:SF120 MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED NEUDESIN receptor ligand activity#GO:0048018;growth factor activity#GO:0008083;signaling receptor regulator activity#GO:0030545;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=24352|UniProtKB=Q8IZW8 Q8IZW8 TNS4 PTHR45734:SF6 TENSIN TENSIN-4 anchoring junction#GO:0070161;cell-substrate junction#GO:0030055;focal adhesion#GO:0005925;cellular anatomical structure#GO:0110165;cell junction#GO:0030054 cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165;actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=8171|UniProtKB=Q8NGC4 Q8NGC4 OR10G3 PTHR26453:SF69 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 10G3 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 response to stimulus#GO:0050896;response to chemical#GO:0042221;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;detection of chemical stimulus#GO:0009593;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;system process#GO:0003008;sensory perception#GO:0007600;nervous system process#GO:0050877;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=17038|UniProtKB=Q99685 Q99685 MGLL PTHR11614:SF198 PHOSPHOLIPASE-RELATED MONOGLYCERIDE LIPASE lipase activity#GO:0016298;catalytic activity#GO:0003824;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787 cellular anatomical structure#GO:0110165;membrane#GO:0016020 phospholipase#PC00186;lipase#PC00143 HUMAN|HGNC=3600|UniProtKB=P23142 P23142 FBLN1 PTHR24050:SF29 PA14 DOMAIN-CONTAINING PROTEIN FIBULIN-1 HUMAN|HGNC=8136|UniProtKB=P47874 P47874 OMP PTHR15357:SF0 OLFACTORY MARKER PROTEIN OLFACTORY MARKER PROTEIN sensory perception of smell#GO:0007608;cell differentiation#GO:0030154;anatomical structure development#GO:0048856;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;nervous system process#GO:0050877;sensory perception#GO:0007600;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;cellular process#GO:0009987;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;neurogenesis#GO:0022008;system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606;developmental process#GO:0032502 cytoplasm#GO:0005737;somatodendritic compartment#GO:0036477;nucleus#GO:0005634;neuron projection#GO:0043005;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;axon#GO:0030424;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;neuronal cell body#GO:0043025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cell body#GO:0044297 HUMAN|HGNC=15722|UniProtKB=Q8WXQ8 Q8WXQ8 CPA5 PTHR11705:SF16 PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B CARBOXYPEPTIDASE A5 catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;catalytic activity#GO:0003824;metalloexopeptidase activity#GO:0008235;exopeptidase activity#GO:0008238;hydrolase activity#GO:0016787;metallocarboxypeptidase activity#GO:0004181;carboxypeptidase activity#GO:0004180;metallopeptidase activity#GO:0008237 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;metabolic process#GO:0008152;proteolysis#GO:0006508;cellular process#GO:0009987 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 HUMAN|HGNC=10259|UniProtKB=Q92753 Q92753 RORB PTHR45805:SF6 NUCLEAR HORMONE RECEPTOR HR3-RELATED NUCLEAR RECEPTOR ROR-BETA sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;cis-regulatory region sequence-specific DNA binding#GO:0000987;nuclear receptor activity#GO:0004879;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976 regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C4 zinc finger nuclear receptor#PC00169 HUMAN|HGNC=556|UniProtKB=O75843 O75843 AP1G2 PTHR22780:SF28 ADAPTIN, ALPHA/GAMMA/EPSILON AP-1 COMPLEX SUBUNIT GAMMA-LIKE 2 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;cargo adaptor activity#GO:0140312 post-Golgi vesicle-mediated transport#GO:0006892;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;transport#GO:0006810;Golgi vesicle transport#GO:0048193;intracellular transport#GO:0046907;cytosolic transport#GO:0016482;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;Golgi to endosome transport#GO:0006895 protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;vesicle coat#GO:0030120;cytoplasm#GO:0005737;clathrin-coated vesicle membrane#GO:0030665;AP-type membrane coat adaptor complex#GO:0030119;bounding membrane of organelle#GO:0098588;clathrin vesicle coat#GO:0030125;organelle#GO:0043226;clathrin coat#GO:0030118;cellular anatomical structure#GO:0110165;Golgi-associated vesicle membrane#GO:0030660;coated vesicle membrane#GO:0030662;intracellular vesicle#GO:0097708;coated membrane#GO:0048475;coated vesicle#GO:0030135;intracellular organelle#GO:0043229;transport vesicle#GO:0030133;endomembrane system#GO:0012505;transport vesicle membrane#GO:0030658;vesicle membrane#GO:0012506;membrane#GO:0016020;organelle membrane#GO:0031090;Golgi apparatus#GO:0005794;trans-Golgi network transport vesicle membrane#GO:0012510;Golgi-associated vesicle#GO:0005798;clathrin-coated vesicle#GO:0030136;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;vesicle#GO:0031982;membrane coat#GO:0030117;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;trans-Golgi network transport vesicle#GO:0030140;AP-1 adaptor complex#GO:0030121 membrane traffic protein#PC00150 HUMAN|HGNC=18509|UniProtKB=Q96LA6 Q96LA6 FCRL1 PTHR11481:SF117 IMMUNOGLOBULIN FC RECEPTOR FC RECEPTOR-LIKE PROTEIN 1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;signal transduction#GO:0007165;regulation of biological process#GO:0050789;immune response#GO:0006955;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;immune system process#GO:0002376;cell surface receptor signaling pathway#GO:0007166 cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=2683|UniProtKB=Q96EP5 Q96EP5 DAZAP1 PTHR48027:SF23 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED DAZ-ASSOCIATED PROTEIN 1 nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;RNA binding#GO:0003723;mRNA 3'-UTR binding#GO:0003730;single-stranded RNA binding#GO:0003727 positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of mRNA processing#GO:0050684;male gamete generation#GO:0048232;developmental process#GO:0032502;spermatogenesis#GO:0007283;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of mRNA splicing, via spliceosome#GO:0048024;developmental process involved in reproduction#GO:0003006;reproductive process#GO:0022414;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;sexual reproduction#GO:0019953;multicellular organismal reproductive process#GO:0048609;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of mRNA metabolic process#GO:1903313;regulation of mRNA metabolic process#GO:1903311;regulation of biological process#GO:0050789;gamete generation#GO:0007276;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;perinuclear region of cytoplasm#GO:0048471;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229 HUMAN|HGNC=39|UniProtKB=Q8IUA7 Q8IUA7 ABCA9 PTHR19229:SF120 ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 9 molecular carrier activity#GO:0140104;lipid carrier activity#GO:0005319;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804 transport#GO:0006810;lipid localization#GO:0010876;macromolecule localization#GO:0033036;localization#GO:0051179;lipid transport#GO:0006869;establishment of localization#GO:0051234 intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 ATP-binding cassette (ABC) transporter#PC00003 HUMAN|HGNC=10080|UniProtKB=Q15287 Q15287 RNPS1 PTHR15481:SF2 RIBONUCLEIC ACID BINDING PROTEIN S1 RNA-BINDING PROTEIN WITH SERINE-RICH DOMAIN 1 mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380 nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 RNA processing factor#PC00147;RNA splicing factor#PC00148;RNA metabolism protein#PC00031 HUMAN|HGNC=53615|UniProtKB=P0DPD8 P0DPD8 EEF1AKMT4-ECE2 PTHR11733:SF127 ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED EEF1AKMT4-ECE2 READTHROUGH TRANSCRIPT PROTEIN-RELATED catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;metalloendopeptidase activity#GO:0004222 metabolic process#GO:0008152;proteolysis#GO:0006508;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein processing#GO:0016485;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 metalloprotease#PC00153;protease#PC00190 Endothelin signaling pathway#P00019>ECE1-3#P00585 HUMAN|HGNC=18855|UniProtKB=Q68CJ9 Q68CJ9 CREB3L3 PTHR45996:SF1 AGAP001464-PB CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 3 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 Transcription regulation by bZIP transcription factor#P00055>CREB#P01383;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>CPB#P00702;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>CREB#P00713 HUMAN|HGNC=23261|UniProtKB=Q6ZRK6 Q6ZRK6 CCDC73 PTHR28660:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 73 COILED-COIL DOMAIN-CONTAINING PROTEIN 73 HUMAN|HGNC=4037|UniProtKB=P06241 P06241 FYN PTHR24418:SF44 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE FYN transferase activity#GO:0016740;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;signaling receptor binding#GO:0005102;binding#GO:0005488;non-membrane spanning protein tyrosine kinase activity#GO:0004715;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein binding#GO:0005515;protein kinase activity#GO:0004672 enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;immune system process#GO:0002376;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of immune response#GO:0050776;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cell differentiation#GO:0030154;immune response-activating cell surface receptor signaling pathway#GO:0002429;signaling#GO:0023052;immune response-regulating signaling pathway#GO:0002764;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cellular developmental process#GO:0048869;immune response-activating signaling pathway#GO:0002757;T cell receptor signaling pathway#GO:0050852;regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166;positive regulation of immune response#GO:0050778;developmental process#GO:0032502;antigen receptor-mediated signaling pathway#GO:0050851;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;positive regulation of immune system process#GO:0002684;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;activation of immune response#GO:0002253 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 non-receptor tyrosine protein kinase#PC00168 Integrin signalling pathway#P00034>Fyn#P00942;Cadherin signaling pathway#P00012>Fyn#P00464;Parkinson disease#P00049>Src kinase#P01230;Axon guidance mediated by semaphorins#P00007>Fyn#P00335;Parkinson disease#P00049>Fyn kinase#P01235 HUMAN|HGNC=31037|UniProtKB=Q7RTY0 Q7RTY0 SLC16A13 PTHR11360:SF19 MONOCARBOXYLATE TRANSPORTER MONOCARBOXYLATE TRANSPORTER 13 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;carboxylic acid transmembrane transporter activity#GO:0046943;monocarboxylic acid transmembrane transporter activity#GO:0008028 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227 HUMAN|HGNC=20636|UniProtKB=Q09FC8 Q09FC8 ZNF415 PTHR24377:SF649 IP01015P-RELATED ZINC FINGER PROTEIN 415-RELATED transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=16976|UniProtKB=Q7Z465 Q7Z465 BNIPL PTHR12112:SF21 BNIP - RELATED BCL-2_ADENOVIRUS E1B 19 KDA-INTERACTING PROTEIN 2-LIKE PROTEIN programmed cell death#GO:0012501;cell death#GO:0008219;apoptotic process#GO:0006915;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 phosphodiesterase#PC00185;metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HUMAN|HGNC=2681|UniProtKB=Q9UER7 Q9UER7 DAXX PTHR12766:SF13 DEATH DOMAIN-ASSOCIATED PROTEIN 6 DAXX DEATH DOMAIN-ASSOCIATED PROTEIN 6 nuclear receptor binding#GO:0016922;transcription factor binding#GO:0008134;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;binding#GO:0005488;DNA-binding transcription factor binding#GO:0140297;RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629;protein binding#GO:0005515 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;apoptotic signaling pathway#GO:0097190;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;programmed cell death#GO:0012501;regulation of biological process#GO:0050789;apoptotic process#GO:0006915;cell death#GO:0008219;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;signaling#GO:0023052;cell communication#GO:0007154;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;nuclear body#GO:0016604;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228;organelle lumen#GO:0043233;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;PML body#GO:0016605;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 Apoptosis signaling pathway#P00006>DAXX#P00296;FAS signaling pathway#P00020>DAXX#P00602 HUMAN|HGNC=30477|UniProtKB=Q6MZM0 Q6MZM0 HEPHL1 PTHR11709:SF233 MULTI-COPPER OXIDASE FERROXIDASE HEPHL1 oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on metal ions#GO:0016722;catalytic activity#GO:0003824 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 oxidase#PC00175 HUMAN|HGNC=16650|UniProtKB=Q9H9J2 Q9H9J2 MRPL44 PTHR11207:SF5 RIBONUCLEASE III LARGE RIBOSOMAL SUBUNIT PROTEIN ML44 catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;RNA endonuclease activity#GO:0004521;catalytic activity, acting on RNA#GO:0140098;binding#GO:0005488;nucleic acid binding#GO:0003676;double-stranded RNA binding#GO:0003725;RNA binding#GO:0003723;hydrolase activity#GO:0016787;nuclease activity#GO:0004518 translation#GO:0006412;protein metabolic process#GO:0019538;mitochondrial gene expression#GO:0140053;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of cellular process#GO:0050794;mitochondrial translation#GO:0032543;regulation of macromolecule metabolic process#GO:0060255;RNA biosynthetic process#GO:0032774;negative regulation of cellular process#GO:0048523;regulatory ncRNA-mediated gene silencing#GO:0031047;regulation of biosynthetic process#GO:0009889;regulatory ncRNA processing#GO:0070918;macromolecule metabolic process#GO:0043170;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;macromolecule biosynthetic process#GO:0009059;negative regulation of macromolecule metabolic process#GO:0010605;biosynthetic process#GO:0009058;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;miRNA processing#GO:0035196;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;protein biosynthetic process#GO:0160307;negative regulation of metabolic process#GO:0009892;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;translational elongation#GO:0006414;primary miRNA processing#GO:0031053;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;gene expression#GO:0010467;RNA processing#GO:0006396 ribosome#GO:0005840;mitochondrion#GO:0005739;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;large ribosomal subunit#GO:0015934;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;mitochondrial ribosome#GO:0005761;intracellular anatomical structure#GO:0005622;organellar ribosome#GO:0000313;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;membraneless organelle#GO:0043228;mitochondrial large ribosomal subunit#GO:0005762 endoribonuclease#PC00094;RNA metabolism protein#PC00031 HUMAN|HGNC=30799|UniProtKB=Q9BZD6 Q9BZD6 PRRG4 PTHR24278:SF38 COAGULATION FACTOR TRANSMEMBRANE GAMMA-CARBOXYGLUTAMIC ACID PROTEIN 4 serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233 membrane#GO:0016020;extracellular region#GO:0005576;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 serine protease#PC00203 HUMAN|HGNC=25037|UniProtKB=Q5TBK1 Q5TBK1 N4BP2L1 PTHR13308:SF5 NEDD4-BINDING PROTEIN 2-LIKE 1 NEDD4-BINDING PROTEIN 2-LIKE 1 HUMAN|HGNC=28192|UniProtKB=Q96SK3 Q96SK3 ZNF607 PTHR24377:SF819 IP01015P-RELATED ZINC FINGER PROTEIN 607 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987 regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=30288|UniProtKB=Q9NZJ0 Q9NZJ0 DTL PTHR22852:SF2 LETHAL 2 DENTICLELESS PROTEIN RETINOIC ACID-REGULATED NUCLEAR MATRIX-ASSOCIATED PROTEIN DENTICLELESS PROTEIN HOMOLOG protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 regulation of biological process#GO:0050789;signal transduction in response to DNA damage#GO:0042770;cell cycle process#GO:0022402;negative regulation of biological process#GO:0048519;negative regulation of cell cycle phase transition#GO:1901988;signaling#GO:0023052;regulation of cell cycle#GO:0051726;response to stimulus#GO:0050896;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;modification-dependent macromolecule catabolic process#GO:0043632;negative regulation of mitotic cell cycle#GO:0045930;mitotic G2 DNA damage checkpoint signaling#GO:0007095;regulation of mitotic cell cycle phase transition#GO:1901990;signal transduction#GO:0007165;cellular process#GO:0009987;response to stress#GO:0006950;regulation of cell cycle process#GO:0010564;proteasomal protein catabolic process#GO:0010498;negative regulation of mitotic cell cycle phase transition#GO:1901991;cell cycle checkpoint signaling#GO:0000075;negative regulation of G2/M transition of mitotic cell cycle#GO:0010972;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;negative regulation of cell cycle G2/M phase transition#GO:1902750;negative regulation of cell cycle#GO:0045786;modification-dependent protein catabolic process#GO:0019941;cellular response to stimulus#GO:0051716;mitotic DNA damage checkpoint signaling#GO:0044773;mitotic cell cycle checkpoint signaling#GO:0007093;regulation of cell cycle phase transition#GO:1901987;cell cycle#GO:0007049;primary metabolic process#GO:0044238;catabolic process#GO:0009056;mitotic cell cycle#GO:0000278;regulation of cellular process#GO:0050794;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;regulation of G2/M transition of mitotic cell cycle#GO:0010389;protein metabolic process#GO:0019538;mitotic G2/M transition checkpoint#GO:0044818;mitotic DNA integrity checkpoint signaling#GO:0044774;regulation of mitotic cell cycle#GO:0007346;regulation of cell cycle G2/M phase transition#GO:1902749;DNA integrity checkpoint signaling#GO:0031570;biological regulation#GO:0065007;DNA damage checkpoint signaling#GO:0000077;DNA damage response#GO:0006974;negative regulation of cell cycle process#GO:0010948;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;negative regulation of cellular process#GO:0048523;mitotic cell cycle process#GO:1903047;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=21011|UniProtKB=Q8IVL8 Q8IVL8 CPO PTHR11705:SF19 PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B CARBOXYPEPTIDASE O metallopeptidase activity#GO:0008237;carboxypeptidase activity#GO:0004180;exopeptidase activity#GO:0008238;hydrolase activity#GO:0016787;metallocarboxypeptidase activity#GO:0004181;metalloexopeptidase activity#GO:0008235;catalytic activity#GO:0003824;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096 primary metabolic process#GO:0044238;metabolic process#GO:0008152;proteolysis#GO:0006508;cellular process#GO:0009987;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 HUMAN|HGNC=14492|UniProtKB=Q8IXM3 Q8IXM3 MRPL41 PTHR21338:SF0 MITOCHONDRIAL RIBOSOMAL PROTEIN L41 LARGE RIBOSOMAL SUBUNIT PROTEIN ML41 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 biosynthetic process#GO:0009058;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;translation#GO:0006412;metabolic process#GO:0008152 intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organellar ribosome#GO:0000313;mitochondrial ribosome#GO:0005761;organelle lumen#GO:0043233;mitochondrion#GO:0005739;ribosome#GO:0005840;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;membraneless organelle#GO:0043228;mitochondrial large ribosomal subunit#GO:0005762;membrane-enclosed lumen#GO:0031974;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737 ribosomal protein#PC00202;translational protein#PC00263 HUMAN|HGNC=21193|UniProtKB=Q3MJ62 Q3MJ62 ZSCAN23 PTHR23226:SF76 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 23 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=15882|UniProtKB=Q9NV79 Q9NV79 PCMTD2 PTHR11579:SF2 PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN 2 catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741;protein methyltransferase activity#GO:0008276;O-methyltransferase activity#GO:0008171;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 transferase#PC00220;methyltransferase#PC00155 HUMAN|HGNC=13363|UniProtKB=Q9H2W2 Q9H2W2 MIXL1 PTHR47656:SF1 HOMEOBOX PROTEIN MIXL HOMEOBOX PROTEIN MIXL1 double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 homeodomain transcription factor#PC00119 HUMAN|HGNC=15577|UniProtKB=P58107 P58107 EPPK1 PTHR23169:SF21 ENVOPLAKIN EPIPLAKIN binding#GO:0005488 intermediate filament cytoskeleton organization#GO:0045104;response to stimulus#GO:0050896;cellular component organization#GO:0016043;supramolecular fiber organization#GO:0097435;wound healing#GO:0042060;intermediate filament organization#GO:0045109;intermediate filament-based process#GO:0045103;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;response to stress#GO:0006950;response to wounding#GO:0009611;cellular component organization or biogenesis#GO:0071840;intermediate filament bundle assembly#GO:0045110 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;intermediate filament#GO:0005882;supramolecular fiber#GO:0099512;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cell junction#GO:0030054;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;organelle#GO:0043226;supramolecular complex#GO:0099080 intermediate filament#PC00129;intermediate filament binding protein#PC00130 HUMAN|HGNC=25048|UniProtKB=Q96HW7 Q96HW7 INTS4 PTHR20938:SF0 INTEGRATOR COMPLEX SUBUNIT 4 INTEGRATOR COMPLEX SUBUNIT 4 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;snRNA 3'-end processing#GO:0034472;catabolic process#GO:0009056;DNA-templated transcription initiation#GO:0006352;nucleic acid biosynthetic process#GO:0141187;RNA catabolic process#GO:0006401;RNA metabolic process#GO:0016070;snRNA metabolic process#GO:0016073;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;nucleic acid catabolic process#GO:0141188;nucleobase-containing compound catabolic process#GO:0034655;transcription initiation at RNA polymerase II promoter#GO:0006367;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule catabolic process#GO:0009057;snRNA processing#GO:0016180;RNA 3'-end processing#GO:0031123;macromolecule metabolic process#GO:0043170 integrator complex#GO:0032039;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=29028|UniProtKB=Q2TAZ0 Q2TAZ0 ATG2A PTHR13190:SF21 AUTOPHAGY-RELATED 2, ISOFORM A AUTOPHAGY-RELATED PROTEIN 2 HOMOLOG A phosphatidylinositol phosphate binding#GO:1901981;phosphatidylinositol-3-phosphate binding#GO:0032266;phospholipid binding#GO:0005543;molecular adaptor activity#GO:0060090;protein-membrane adaptor activity#GO:0043495;lipid binding#GO:0008289;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674 cellular component organization or biogenesis#GO:0071840;autophagosome assembly#GO:0000045;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;cellular component assembly#GO:0022607;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;autophagy#GO:0006914;cellular process#GO:0009987;autophagosome organization#GO:1905037;carbohydrate catabolic process#GO:0016052;process utilizing autophagic mechanism#GO:0061919;polysaccharide metabolic process#GO:0005976;glucan catabolic process#GO:0009251;cellular component organization#GO:0016043;glucan metabolic process#GO:0044042;polysaccharide catabolic process#GO:0000272;pexophagy#GO:0000425;macromolecule metabolic process#GO:0043170;energy derivation by oxidation of organic compounds#GO:0015980;autophagy of mitochondrion#GO:0000422;generation of precursor metabolites and energy#GO:0006091;macroautophagy#GO:0016236;glycogen catabolic process#GO:0005980;reticulophagy#GO:0061709;vacuole organization#GO:0007033;energy reserve metabolic process#GO:0006112;organelle assembly#GO:0070925;catabolic process#GO:0009056;carbohydrate metabolic process#GO:0005975;piecemeal microautophagy of the nucleus#GO:0034727;glycogen metabolic process#GO:0005977;primary metabolic process#GO:0044238 phagophore assembly site#GO:0000407;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=29480|UniProtKB=P02750 P02750 LRG1 PTHR45617:SF101 LEUCINE RICH REPEAT FAMILY PROTEIN LEUCINE-RICH ALPHA-2-GLYCOPROTEIN protein binding#GO:0005515;signaling receptor binding#GO:0005102;cytokine receptor binding#GO:0005126;binding#GO:0005488 regulation of vasculature development#GO:1901342;regulation of response to stimulus#GO:0048583;developmental process#GO:0032502;positive regulation of developmental process#GO:0051094;response to wounding#GO:0009611;positive regulation of cellular process#GO:0048522;tissue development#GO:0009888;cell migration#GO:0016477;positive regulation of response to stimulus#GO:0048584;epithelium development#GO:0060429;regulation of signal transduction#GO:0009966;regulation of cellular response to growth factor stimulus#GO:0090287;biological regulation#GO:0065007;anatomical structure development#GO:0048856;tissue morphogenesis#GO:0048729;regulation of angiogenesis#GO:0045765;positive regulation of signal transduction#GO:0009967;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092;regulation of transforming growth factor beta receptor signaling pathway#GO:0017015;positive regulation of cell communication#GO:0010647;cell motility#GO:0048870;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of developmental process#GO:0050793;regulation of anatomical structure morphogenesis#GO:0022603;morphogenesis of an epithelium#GO:0002009;response to stress#GO:0006950;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;regulation of multicellular organismal process#GO:0051239;animal gross anatomical part developmental process#GO:0160108;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;wound healing#GO:0042060;positive regulation of angiogenesis#GO:0045766;positive regulation of multicellular organismal process#GO:0051240;regulation of multicellular organismal development#GO:2000026;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;response to stimulus#GO:0050896 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=4189|UniProtKB=Q92947 Q92947 GCDH PTHR42807:SF1 GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL metabolite interconversion enzyme#PC00262;dehydrogenase#PC00092 HUMAN|HGNC=22198|UniProtKB=O75127 O75127 PTCD1 PTHR24014:SF6 2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE DOMAIN-CONTAINING PROTEIN 2 PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 1, MITOCHONDRIAL tRNA binding#GO:0000049;RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;tRNA 3'-end processing#GO:0042780;mitochondrial RNA modification#GO:1900864;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;mitochondrial RNA metabolic process#GO:0000959;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;mitochondrion#GO:0005739 RNA metabolism protein#PC00031 HUMAN|HGNC=11124|UniProtKB=P55854 P55854 SUMO3 PTHR10562:SF74 SMALL UBIQUITIN-RELATED MODIFIER SMALL UBIQUITIN-RELATED MODIFIER 3 binding#GO:0005488;ubiquitin-like protein ligase binding#GO:0044389;enzyme binding#GO:0019899;protein binding#GO:0005515 primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein modification by small protein conjugation#GO:0032446;cellular process#GO:0009987;post-translational protein modification#GO:0043687;protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein sumoylation#GO:0016925 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 p53 pathway#P00059>Sumo-1 ligase#P04635 HUMAN|HGNC=29045|UniProtKB=Q9NUA8 Q9NUA8 ZBTB40 PTHR24394:SF0 ZINC FINGER PROTEIN ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 40 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HUMAN|HGNC=9217|UniProtKB=P49335 P49335 POU3F4 PTHR11636:SF83 POU DOMAIN POU DOMAIN, CLASS 3, TRANSCRIPTION FACTOR 4 transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=18283|UniProtKB=Q8WXH6 Q8WXH6 RAB40A PTHR47980:SF43 LD44762P RAS-RELATED PROTEIN RAB-40A ubiquitin-like ligase-substrate adaptor activity#GO:1990756;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;enzyme-substrate adaptor activity#GO:0140767 localization#GO:0051179;secretion#GO:0046903;protein metabolic process#GO:0019538;secretion by cell#GO:0032940;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;catabolic process#GO:0009056;export from cell#GO:0140352;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;establishment of localization#GO:0051234;exocytosis#GO:0006887;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;transport#GO:0006810;vesicle-mediated transport#GO:0016192;proteasomal protein catabolic process#GO:0010498;cellular process#GO:0009987 plasma membrane#GO:0005886;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;cell periphery#GO:0071944;intracellular vesicle#GO:0097708;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768 HUMAN|HGNC=2300|UniProtKB=Q96IY4 Q96IY4 CPB2 PTHR11705:SF17 PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B CARBOXYPEPTIDASE B2 catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;catalytic activity#GO:0003824;metalloexopeptidase activity#GO:0008235;metallocarboxypeptidase activity#GO:0004181;hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;carboxypeptidase activity#GO:0004180;metallopeptidase activity#GO:0008237 negative regulation of coagulation#GO:0050819;protein metabolic process#GO:0019538;regulation of biological quality#GO:0065008;proteolysis#GO:0006508;negative regulation of hemostasis#GO:1900047;regulation of body fluid levels#GO:0050878;regulation of blood coagulation#GO:0030193;regulation of wound healing#GO:0061041;primary metabolic process#GO:0044238;negative regulation of biological process#GO:0048519;negative regulation of multicellular organismal process#GO:0051241;regulation of biological process#GO:0050789;negative regulation of response to wounding#GO:1903035;macromolecule metabolic process#GO:0043170;negative regulation of blood coagulation#GO:0030195;regulation of response to stress#GO:0080134;metabolic process#GO:0008152;regulation of response to stimulus#GO:0048583;negative regulation of response to stimulus#GO:0048585;regulation of response to external stimulus#GO:0032101;fibrinolysis#GO:0042730;regulation of coagulation#GO:0050818;regulation of multicellular organismal process#GO:0051239;negative regulation of response to external stimulus#GO:0032102;biological regulation#GO:0065007;negative regulation of wound healing#GO:0061045;regulation of response to wounding#GO:1903034;regulation of hemostasis#GO:1900046;cellular process#GO:0009987 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 Plasminogen activating cascade#P00050>TAFI#P01247 HUMAN|HGNC=3656|UniProtKB=Q9NZM1 Q9NZM1 MYOF PTHR12546:SF55 FER-1-LIKE MYOFERLIN lipid binding#GO:0008289;binding#GO:0005488;phospholipid binding#GO:0005543 cellular process#GO:0009987;response to wounding#GO:0009611;response to stress#GO:0006950;membrane fusion#GO:0061025;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;developmental process#GO:0032502;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;muscle cell differentiation#GO:0042692;cellular component organization#GO:0016043;muscle cell development#GO:0055001;cell development#GO:0048468;muscle structure development#GO:0061061;response to stimulus#GO:0050896;cell differentiation#GO:0030154;animal gross anatomical part developmental process#GO:0160108;wound healing#GO:0042060;anatomical structure development#GO:0048856;plasma membrane organization#GO:0007009 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=13535|UniProtKB=O60423 O60423 ATP8B3 PTHR24092:SF78 PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE PHOSPHOLIPID-TRANSPORTING ATPASE IK ATPase-coupled intramembrane lipid carrier activity#GO:0140326;ATP-dependent activity#GO:0140657;transporter activity#GO:0005215;lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104;intramembrane lipid carrier activity#GO:0140303 lipid transport#GO:0006869;phospholipid transport#GO:0015914;phospholipid translocation#GO:0045332;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;biological regulation#GO:0065007;macromolecule localization#GO:0033036;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;regulation of membrane lipid distribution#GO:0097035;transport#GO:0006810;organophosphate ester transport#GO:0015748;lipid translocation#GO:0034204;cellular component organization#GO:0016043;Golgi organization#GO:0007030;localization#GO:0051179;regulation of biological quality#GO:0065008;lipid localization#GO:0010876 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;plasma membrane#GO:0005886;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;cell periphery#GO:0071944;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 transporter#PC00227;primary active transporter#PC00068 HUMAN|HGNC=11628|UniProtKB=O60765 O60765 ZNF354A PTHR24377:SF146 IP01015P-RELATED ZINC FINGER PROTEIN 354A transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=2194|UniProtKB=Q9UMD9 Q9UMD9 COL17A1 PTHR24023:SF891 COLLAGEN ALPHA COLLAGEN ALPHA-1(XVII) CHAIN structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;external encapsulating structure organization#GO:0045229;extracellular structure organization#GO:0043062;cellular component organization#GO:0016043;cellular process#GO:0009987 external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576;cell junction#GO:0030054;cellular anatomical structure#GO:0110165;cell-substrate junction#GO:0030055;anchoring junction#GO:0070161 extracellular matrix structural protein#PC00103;extracellular matrix protein#PC00102 Integrin signalling pathway#P00034>Collagen#P00922 HUMAN|HGNC=26555|UniProtKB=Q3SY00 Q3SY00 TSGA10IP PTHR21501:SF5 PROTEIN FAM-161 TESTIS-SPECIFIC PROTEIN 10-INTERACTING PROTEIN cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;cell projection organization#GO:0030030;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection organization#GO:0120036;cilium organization#GO:0044782 membrane-bounded organelle#GO:0043227;non-motile cilium#GO:0097730;ciliary transition zone#GO:0035869;cilium#GO:0005929;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;9+0 non-motile cilium#GO:0097731;neuron projection#GO:0043005;photoreceptor cell cilium#GO:0097733 HUMAN|HGNC=17990|UniProtKB=Q96PB7 Q96PB7 OLFM3 PTHR23192:SF36 OLFACTOMEDIN-RELATED NOELIN-3 cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 structural protein#PC00211 HUMAN|HGNC=1037|UniProtKB=P00751 P00751 CFB PTHR46393:SF1 SUSHI DOMAIN-CONTAINING PROTEIN COMPLEMENT FACTOR B response to stimulus#GO:0050896;regulation of immune system process#GO:0002682;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;regulation of biological process#GO:0050789;immune system process#GO:0002376;response to bacterium#GO:0009617;regulation of immune response#GO:0050776;positive regulation of response to stimulus#GO:0048584;defense response to other organism#GO:0098542;biological regulation#GO:0065007;response to other organism#GO:0051707;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;positive regulation of immune system process#GO:0002684;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;defense response to symbiont#GO:0140546;complement activation#GO:0006956;immune response#GO:0006955;innate immune response#GO:0045087;response to external stimulus#GO:0009605;defense response#GO:0006952;humoral immune response#GO:0006959;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;immune effector process#GO:0002252 HUMAN|HGNC=13311|UniProtKB=Q96QA5 Q96QA5 GSDMA PTHR16399:SF18 GASDERMIN GASDERMIN-A transporter#PC00227 HUMAN|HGNC=12642|UniProtKB=P23763 P23763 VAMP1 PTHR45701:SF1 SYNAPTOBREVIN FAMILY MEMBER VESICLE-ASSOCIATED MEMBRANE PROTEIN 1 protein binding#GO:0005515;SNAP receptor activity#GO:0005484;syntaxin binding#GO:0019905;binding#GO:0005488;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;SNARE binding#GO:0000149 organelle membrane fusion#GO:0090174;membrane organization#GO:0061024;vesicle-mediated transport#GO:0016192;organelle fusion#GO:0048284;cellular component assembly#GO:0022607;cellular process#GO:0009987;organelle organization#GO:0006996;membrane fusion#GO:0061025;cellular component biogenesis#GO:0044085;protein-containing complex organization#GO:0043933;vesicle organization#GO:0016050;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;transport#GO:0006810;vesicle fusion#GO:0006906;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;localization#GO:0051179 intracellular anatomical structure#GO:0005622;cell periphery#GO:0071944;membrane#GO:0016020;membrane protein complex#GO:0098796;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;SNARE complex#GO:0031201;protein-containing complex#GO:0032991 membrane traffic protein#PC00150 5HT3 type receptor mediated signaling pathway#P04375>SNARE Complex#P04423;Opioid prodynorphin pathway#P05916>SNARE Complex#P05996;Dopamine receptor mediated signaling pathway#P05912>SNARE Complex#P05956;Beta2 adrenergic receptor signaling pathway#P04378>SNARE Complex#P04442;Beta3 adrenergic receptor signaling pathway#P04379>SNARE Complex#P04447;Synaptic vesicle trafficking#P05734>Synaptobrevin#P05779;Adrenaline and noradrenaline biosynthesis#P00001>SNARE#P00072;Beta1 adrenergic receptor signaling pathway#P04377>SNARE Complex#P04435;5HT1 type receptor mediated signaling pathway#P04373>SNARE Complex#P04405;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>SNARE Complex#P01079;Alpha adrenergic receptor signaling pathway#P00002>SNARE#P00074;5HT4 type receptor mediated signaling pathway#P04376>SNARE Complex#P04428;5HT2 type receptor mediated signaling pathway#P04374>SNARE Complex#P04415;Opioid proenkephalin pathway#P05915>SNARE Complex#P05986;Oxytocin receptor mediated signaling pathway#P04391>SNARE Complex#P04532;Thyrotropin-releasing hormone receptor signaling pathway#P04394>SNARE Complex#P04582;Metabotropic glutamate receptor group III pathway#P00039>SNARE Complex#P01042;Cortocotropin releasing factor receptor signaling pathway#P04380>SNARE Complex#P04457;Nicotinic acetylcholine receptor signaling pathway#P00044>SNARE Complex#P01091;Ionotropic glutamate receptor pathway#P00037>SNARE Complex#P01013;Metabotropic glutamate receptor group II pathway#P00040>SNARE Complex#P01049;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>SNARE Complex#P01066;Opioid proopiomelanocortin pathway#P05917>SNARE Complex#P06005 HUMAN|HGNC=5985|UniProtKB=Q96F46 Q96F46 IL17RA PTHR15583:SF13 INTERLEUKIN-17 RECEPTOR INTERLEUKIN-17 RECEPTOR A cytokine receptor activity#GO:0004896;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;immune receptor activity#GO:0140375;signaling receptor activity#GO:0038023 positive regulation of multicellular organismal process#GO:0051240;cellular response to stimulus#GO:0051716;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;positive regulation of cytokine production#GO:0001819;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;response to stimulus#GO:0050896;signaling#GO:0023052;cytokine-mediated signaling pathway#GO:0019221;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;cell communication#GO:0007154;positive regulation of metabolic process#GO:0009893;response to peptide#GO:1901652;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cytokine production#GO:0001817;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;response to cytokine#GO:0034097;positive regulation of macromolecule metabolic process#GO:0010604;response to chemical#GO:0042221;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;cell surface receptor signaling pathway#GO:0007166;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of gene expression#GO:0010628 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=9003|UniProtKB=O00562 O00562 PITPNM1 PTHR10658:SF40 PHOSPHATIDYLINOSITOL TRANSFER PROTEIN MEMBRANE-ASSOCIATED PHOSPHATIDYLINOSITOL TRANSFER PROTEIN 1 intramembrane lipid carrier activity#GO:0140303;cation binding#GO:0043169;anion binding#GO:0043168;small molecule binding#GO:0036094;phosphatidylcholine intramembrane carrier activity#GO:0008525;lipid carrier activity#GO:0005319;ion binding#GO:0043167;phosphatidylcholine binding#GO:0031210;phosphatidylinositol transfer activity#GO:0008526;phosphatidylinositol binding#GO:0035091;phospholipid binding#GO:0005543;lipid transfer activity#GO:0120013;lipid binding#GO:0008289;binding#GO:0005488;molecular carrier activity#GO:0140104;transporter activity#GO:0005215 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 transporter#PC00227 HUMAN|HGNC=5582|UniProtKB=A0A0B4J1V0 A0A0B4J1V0 IGHV3-15 PTHR23266:SF114 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 3-15 antigen binding#GO:0003823;binding#GO:0005488 response to stimulus#GO:0050896;adaptive immune response#GO:0002250;immune response#GO:0006955;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;immune system process#GO:0002376;immune effector process#GO:0002252 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=16763|UniProtKB=Q9Y2Y4 Q9Y2Y4 ZBTB32 PTHR24399:SF40 ZINC FINGER AND BTB DOMAIN-CONTAINING ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 32 transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription repressor activity#GO:0001217;transcription regulator activity#GO:0140110;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;sequence-specific double-stranded DNA binding#GO:1990837 negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of cytokine production#GO:0001817;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892 intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218 HUMAN|HGNC=10831|UniProtKB=Q99962 Q99962 SH3GL2 PTHR14167:SF50 SH3 DOMAIN-CONTAINING ENDOPHILIN-A1 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 endocytosis#GO:0006897;cellular component organization#GO:0016043;synaptic vesicle endocytosis#GO:0048488;cellular localization#GO:0051641;localization#GO:0051179;membrane organization#GO:0061024;vesicle-mediated transport#GO:0016192;synaptic vesicle recycling#GO:0036465;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle-mediated transport in synapse#GO:0099003;establishment of localization#GO:0051234;import into cell#GO:0098657;cellular component organization or biogenesis#GO:0071840;synaptic vesicle cycle#GO:0099504;transport#GO:0006810 cell junction#GO:0030054;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;presynapse#GO:0098793;synapse#GO:0045202;cellular anatomical structure#GO:0110165;glutamatergic synapse#GO:0098978;cytoplasm#GO:0005737 scaffold/adaptor protein#PC00226 HUMAN|HGNC=7157|UniProtKB=P24347 P24347 MMP11 PTHR10201:SF20 MATRIX METALLOPROTEINASE STROMELYSIN-3 catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;metalloendopeptidase activity#GO:0004222;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 cellular process#GO:0009987;cellular component organization#GO:0016043;catabolic process#GO:0009056;extracellular structure organization#GO:0043062;metabolic process#GO:0008152;external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 HUMAN|HGNC=16688|UniProtKB=O95070 O95070 YIF1A PTHR14083:SF2 YIP1 INTERACTING FACTOR HOMOLOG YIF1 PROTEIN PROTEIN YIF1A vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;transport#GO:0006810;Golgi vesicle transport#GO:0048193;intracellular transport#GO:0046907 cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;intracellular vesicle#GO:0097708;vesicle#GO:0031982;COPII-coated ER to Golgi transport vesicle#GO:0030134;coated vesicle#GO:0030135;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;cytoplasm#GO:0005737;membrane#GO:0016020;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;endoplasmic reticulum membrane#GO:0005789;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;endoplasmic reticulum#GO:0005783 HUMAN|HGNC=24779|UniProtKB=Q8NDZ2 Q8NDZ2 SIMC1 PTHR23187:SF3 FLJ44216 PROTEIN-RELATED SUMO-INTERACTING MOTIF-CONTAINING PROTEIN 1 peptidase inhibitor activity#GO:0030414;peptidase regulator activity#GO:0061134;enzyme inhibitor activity#GO:0004857;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;molecular function inhibitor activity#GO:0140678 membraneless organelle#GO:0043228;nuclear body#GO:0016604;intracellular membraneless organelle#GO:0043232;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;PML body#GO:0016605;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;organelle lumen#GO:0043233 HUMAN|HGNC=26116|UniProtKB=Q8TBK2 Q8TBK2 SETD6 PTHR13271:SF34 UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE N-LYSINE METHYLTRANSFERASE SETD6 protein methyltransferase activity#GO:0008276;transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;N-methyltransferase activity#GO:0008170;protein-lysine N-methyltransferase activity#GO:0016279;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;lysine N-methyltransferase activity#GO:0016278 nucleus#GO:0005634;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 transferase#PC00220;methyltransferase#PC00155 HUMAN|HGNC=3157|UniProtKB=Q92838 Q92838 EDA PTHR15151:SF13 PROTEIN EIGER ECTODYSPLASIN-A molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;cytokine activity#GO:0005125;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018 anatomical structure development#GO:0048856;animal organ development#GO:0048513;developmental process#GO:0032502;immune system process#GO:0002376;animal gross anatomical part developmental process#GO:0160108;odontogenesis#GO:0042476;response to stimulus#GO:0050896;odontogenesis of dentin-containing tooth#GO:0042475;animal organ morphogenesis#GO:0009887;anatomical structure morphogenesis#GO:0009653;immune response#GO:0006955 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HUMAN|HGNC=18677|UniProtKB=Q9NXZ2 Q9NXZ2 DDX43 PTHR47958:SF212 ATP-DEPENDENT RNA HELICASE DBP3 ATP-DEPENDENT RNA HELICASE DDX43-RELATED isomerase activity#GO:0016853;catalytic activity, acting on RNA#GO:0140098;helicase activity#GO:0004386;macromolecular conformation isomerase activity#GO:0120543;catalytic activity#GO:0003824;RNA helicase activity#GO:0003724;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;RNA binding#GO:0003723;ATP-dependent activity#GO:0140657;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729 RNA helicase#PC00032 HUMAN|HGNC=33739|UniProtKB=Q6ZVX7 Q6ZVX7 NCCRP1 PTHR12125:SF1 F-BOX ONLY PROTEIN 6-LIKE PROTEIN F-BOX ONLY PROTEIN 50 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=22567|UniProtKB=Q9H560 Q9H560 ANKRD19P PTHR24147:SF76 ANKYRIN REPEAT DOMAIN 36-RELATED ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 19-RELATED HUMAN|HGNC=32375|UniProtKB=A6NN73 A6NN73 GOLGA8CP PTHR10881:SF7 GOLGIN SUBFAMILY A MEMBER-RELATED GOLGIN SUBFAMILY A CONSERVED DOMAIN-CONTAINING PROTEIN-RELATED cellular process#GO:0009987;Golgi organization#GO:0007030;cellular component organization#GO:0016043;organelle organization#GO:0006996;endomembrane system organization#GO:0010256;cellular component organization or biogenesis#GO:0071840 Golgi cis cisterna#GO:0000137;cytoplasm#GO:0005737;Golgi cisterna#GO:0031985;endomembrane system#GO:0012505;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;cis-Golgi network#GO:0005801;organelle membrane#GO:0031090;Golgi apparatus#GO:0005794;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;Golgi stack#GO:0005795;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 membrane traffic protein#PC00150 HUMAN|HGNC=1322|UniProtKB=Q9NY35 Q9NY35 CLDND1 PTHR14347:SF3 CLAUDIN DOMAIN-CONTAINING PROTEIN 1 CLAUDIN DOMAIN-CONTAINING PROTEIN 1 HUMAN|HGNC=13921|UniProtKB=O95870 O95870 ABHD16A PTHR12277:SF54 ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN PHOSPHATIDYLSERINE LIPASE ABHD16A hydrolase activity, acting on ester bonds#GO:0016788;phospholipase activity#GO:0120569;carboxylic ester hydrolase activity#GO:0052689;lipase activity#GO:0016298;glycerophospholipase activity#GO:0004620;catalytic activity#GO:0003824;hydrolase activity#GO:0016787 primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;modified amino acid metabolic process#GO:0006575;phospholipid metabolic process#GO:0006644;phospholipid catabolic process#GO:0009395;glycerolipid metabolic process#GO:0046486;catabolic process#GO:0009056;glycerolipid catabolic process#GO:0046503;organophosphate catabolic process#GO:0046434;cellular process#GO:0009987;lipid catabolic process#GO:0016042;organophosphate metabolic process#GO:0019637;glycerophospholipid metabolic process#GO:0006650;lipid metabolic process#GO:0006629;neutral lipid catabolic process#GO:0046461;acylglycerol metabolic process#GO:0006639;metabolic process#GO:0008152;acylglycerol catabolic process#GO:0046464;glycerophospholipid catabolic process#GO:0046475;neutral lipid metabolic process#GO:0006638 serine protease#PC00203 HUMAN|HGNC=24213|UniProtKB=Q8IUL8 Q8IUL8 CILP2 PTHR15031:SF0 CARTILAGE INTERMEDIATE LAYER PROTEIN CLIP CARTILAGE INTERMEDIATE LAYER PROTEIN 2 regulation of cell communication#GO:0010646;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=11925|UniProtKB=P50591 P50591 TNFSF10 PTHR11471:SF27 TUMOR NECROSIS FACTOR FAMILY MEMBER TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 10 receptor ligand activity#GO:0048018;cytokine activity#GO:0005125;signaling receptor regulator activity#GO:0030545;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677 regulation of apoptotic signaling pathway#GO:2001233;cell communication#GO:0007154;regulation of extrinsic apoptotic signaling pathway#GO:2001236;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;positive regulation of apoptotic signaling pathway#GO:2001235;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of extrinsic apoptotic signaling pathway#GO:2001238;regulation of canonical NF-kappaB signal transduction#GO:0043122;positive regulation of cellular process#GO:0048522;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;regulation of programmed cell death#GO:0043067;regulation of biological process#GO:0050789;positive regulation of programmed cell death#GO:0043068;response to stimulus#GO:0050896;signaling#GO:0023052;cell surface receptor signaling pathway#GO:0007166;regulation of apoptotic process#GO:0042981;positive regulation of canonical NF-kappaB signal transduction#GO:0043123;positive regulation of apoptotic process#GO:0043065;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 Apoptosis signaling pathway#P00006>TRAIL#P00263 HUMAN|HGNC=26636|UniProtKB=Q8NAP3 Q8NAP3 ZBTB38 PTHR24388:SF71 ZINC FINGER PROTEIN ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 38 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=26459|UniProtKB=Q6NT32 Q6NT32 CES5A PTHR11559:SF43 CARBOXYLESTERASE CARBOXYLESTERASE 5A hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;carboxylic ester hydrolase activity#GO:0052689 esterase#PC00097 HUMAN|HGNC=17156|UniProtKB=Q9Y6Y9 Q9Y6Y9 LY96 PTHR15218:SF0 MD-1, MD-2 - RELATED LYMPHOCYTE ANTIGEN 96 molecular transducer activity#GO:0060089;pattern recognition receptor activity#GO:0038187;signaling receptor activity#GO:0038023 regulation of immune response#GO:0050776;regulation of defense response#GO:0031347;response to bacterium#GO:0009617;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;innate immune response-activating signaling pathway#GO:0002758;positive regulation of signal transduction#GO:0009967;cellular response to biotic stimulus#GO:0071216;response to external biotic stimulus#GO:0043207;regulation of response to biotic stimulus#GO:0002831;immune response-activating cell surface receptor signaling pathway#GO:0002429;regulation of cell communication#GO:0010646;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;positive regulation of defense response#GO:0031349;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;regulation of response to stress#GO:0080134;response to external stimulus#GO:0009605;positive regulation of response to biotic stimulus#GO:0002833;pattern recognition receptor signaling pathway#GO:0002221;regulation of innate immune response#GO:0045088;cellular response to molecule of bacterial origin#GO:0071219;positive regulation of cellular process#GO:0048522;positive regulation of innate immune response#GO:0045089;activation of innate immune response#GO:0002218;detection of stimulus#GO:0051606;immune response-regulating cell surface receptor signaling pathway#GO:0002768;toll-like receptor 4 signaling pathway#GO:0034142;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;response to other organism#GO:0051707;positive regulation of response to stimulus#GO:0048584;response to oxygen-containing compound#GO:1901700;regulation of signaling#GO:0023051;immune system process#GO:0002376;cellular response to chemical stimulus#GO:0070887;positive regulation of signaling#GO:0023056;regulation of biological process#GO:0050789;response to molecule of bacterial origin#GO:0002237;immune response-regulating signaling pathway#GO:0002764;detection of chemical stimulus#GO:0009593;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;cell surface receptor signaling pathway#GO:0007166;response to lipopolysaccharide#GO:0032496;immune response-activating signaling pathway#GO:0002757;positive regulation of response to external stimulus#GO:0032103;cellular response to oxygen-containing compound#GO:1901701;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;signal transduction#GO:0007165;cellular process#GO:0009987;response to biotic stimulus#GO:0009607;cellular response to lipopolysaccharide#GO:0071222;positive regulation of immune system process#GO:0002684;response to chemical#GO:0042221;response to lipid#GO:0033993;cellular response to lipid#GO:0071396;regulation of response to external stimulus#GO:0032101 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;membrane protein complex#GO:0098796;membrane#GO:0016020;signaling receptor complex#GO:0043235 scaffold/adaptor protein#PC00226 Toll receptor signaling pathway#P00054>MD-2#P01347 HUMAN|HGNC=20739|UniProtKB=Q8NFU5 Q8NFU5 IPMK PTHR12400:SF80 INOSITOL POLYPHOSPHATE KINASE INOSITOL POLYPHOSPHATE MULTIKINASE catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773 alcohol metabolic process#GO:0006066;metabolic process#GO:0008152;small molecule biosynthetic process#GO:0044283;organophosphate biosynthetic process#GO:0090407;phosphorus metabolic process#GO:0006793;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;alcohol biosynthetic process#GO:0046165;small molecule metabolic process#GO:0044281;biosynthetic process#GO:0009058 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 kinase#PC00137 HUMAN|HGNC=10625|UniProtKB=Q9Y258 Q9Y258 CCL26 PTHR12015:SF183 SMALL INDUCIBLE CYTOKINE A C-C MOTIF CHEMOKINE 26-RELATED cellular process#GO:0009987;granulocyte migration#GO:0097530;cell migration#GO:0016477;response to chemical#GO:0042221;taxis#GO:0042330;leukocyte migration#GO:0050900;leukocyte chemotaxis#GO:0030595;myeloid leukocyte migration#GO:0097529;response to external stimulus#GO:0009605;cellular response to stimulus#GO:0051716;locomotion#GO:0040011;cell motility#GO:0048870;granulocyte chemotaxis#GO:0071621;response to stimulus#GO:0050896;chemotaxis#GO:0006935;immune system process#GO:0002376;cellular response to chemical stimulus#GO:0070887;cell chemotaxis#GO:0060326 cytokine#PC00083 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CHK#P00856 HUMAN|HGNC=25065|UniProtKB=Q7Z4M0 Q7Z4M0 REC114 PTHR34921:SF1 MEIOTIC RECOMBINATION PROTEIN REC114 MEIOTIC RECOMBINATION PROTEIN REC114 HUMAN|HGNC=21263|UniProtKB=Q96FT7 Q96FT7 ASIC4 PTHR11690:SF13 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED ACID-SENSING ION CHANNEL 4 passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;sodium channel activity#GO:0005272;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;ligand-gated monoatomic cation channel activity#GO:0099094;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic cation channel activity#GO:0005261;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267 establishment of localization#GO:0051234;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;transport#GO:0006810;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;cellular process#GO:0009987;sodium ion transport#GO:0006814;sodium ion transmembrane transport#GO:0035725 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HUMAN|HGNC=20125|UniProtKB=Q8IVF2 Q8IVF2 AHNAK2 PTHR23348:SF37 PERIAXIN/AHNAK PROTEIN AHNAK2 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=12865|UniProtKB=A6NM28 A6NM28 ZFP92 PTHR24377:SF634 IP01015P-RELATED ZINC FINGER PROTEIN 92 HOMOLOG sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690 regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=8481|UniProtKB=Q8WZ84 Q8WZ84 OR8D1 PTHR48018:SF72 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 8D1 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;sensory perception of smell#GO:0007608;sensory perception#GO:0007600;nervous system process#GO:0050877;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=31907|UniProtKB=P0CL81 P0CL81 GAGE12G PTHR14047:SF30 P ANTIGEN FAMILY MEMBER 5-RELATED G ANTIGEN 1-RELATED HUMAN|HGNC=2197|UniProtKB=P02452 P02452 COL1A1 PTHR24023:SF569 COLLAGEN ALPHA COLLAGEN ALPHA-1(I) CHAIN extracellular matrix structural constituent#GO:0005201;structural molecule activity#GO:0005198 multicellular organismal process#GO:0032501;skin development#GO:0043588;skeletal system morphogenesis#GO:0048705;cellular process#GO:0009987;animal organ development#GO:0048513;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;developmental process#GO:0032502;animal organ morphogenesis#GO:0009887;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;extracellular matrix organization#GO:0030198;anatomical structure development#GO:0048856;skeletal system development#GO:0001501;system development#GO:0048731;external encapsulating structure organization#GO:0045229;animal gross anatomical part developmental process#GO:0160108;extracellular structure organization#GO:0043062 extracellular protein-containing complex#GO:0140392;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;interstitial matrix#GO:0005614;supramolecular complex#GO:0099080;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 extracellular matrix structural protein#PC00103;extracellular matrix protein#PC00102 Integrin signalling pathway#P00034>Collagen#P00922 HUMAN|HGNC=5141|UniProtKB=P00738 P00738 HP PTHR24255:SF30 COMPLEMENT COMPONENT 1, S SUBCOMPONENT-RELATED HAPTOGLOBIN serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;serine-type peptidase activity#GO:0008236;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein processing#GO:0016485;zymogen activation#GO:0031638;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604;proteolysis#GO:0006508;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 serine protease#PC00203 HUMAN|HGNC=37161|UniProtKB=P0CJ71 P0CJ71 MTRNR2L4 PTHR33895:SF5 HUMANIN-LIKE 4 HUMANIN-LIKE 4-RELATED signaling receptor regulator activity#GO:0030545;signaling receptor inhibitor activity#GO:0030547;molecular function regulator activity#GO:0098772;molecular function inhibitor activity#GO:0140678 negative regulation of apoptotic process#GO:0043066;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;negative regulation of programmed cell death#GO:0043069;regulation of biological process#GO:0050789;negative regulation of cellular process#GO:0048523;regulation of apoptotic process#GO:0042981 HUMAN|HGNC=13209|UniProtKB=Q12774 Q12774 ARHGEF5 PTHR12845:SF2 GUANINE NUCLEOTIDE EXCHANGE FACTOR DH DOMAIN-CONTAINING PROTEIN-RELATED guanyl-nucleotide exchange factor activity#GO:0005085;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772 regulation of actin filament-based process#GO:0032970;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;regulation of actin cytoskeleton organization#GO:0032956;biological regulation#GO:0065007;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HUMAN|HGNC=11733|UniProtKB=Q8IYF3 Q8IYF3 TEX11 PTHR47083:SF1 TESTIS-EXPRESSED PROTEIN 11 TESTIS-EXPRESSED PROTEIN 11 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cell cycle#GO:0007049;reciprocal homologous recombination#GO:0140527;homologous recombination#GO:0035825;reproductive process#GO:0022414;meiosis I cell cycle process#GO:0061982;sexual reproduction#GO:0019953;organelle fission#GO:0048285;multicellular organismal reproductive process#GO:0048609;male gamete generation#GO:0048232;nucleobase-containing compound metabolic process#GO:0006139;meiotic nuclear division#GO:0140013;macromolecule metabolic process#GO:0043170;meiotic chromosome segregation#GO:0045132;chromosome organization#GO:0051276;meiotic cell cycle process#GO:1903046;meiosis I#GO:0007127;nuclear chromosome segregation#GO:0098813;cellular component organization#GO:0016043;cell cycle process#GO:0022402;gamete generation#GO:0007276;nuclear division#GO:0000280;reciprocal meiotic recombination#GO:0007131;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;synaptonemal complex assembly#GO:0007130;cellular component assembly#GO:0022607;homologous chromosome pairing at meiosis#GO:0007129;male meiotic nuclear division#GO:0007140;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;chromosome organization involved in meiotic cell cycle#GO:0070192;meiotic cell cycle#GO:0051321;DNA recombination#GO:0006310;chromosome segregation#GO:0007059;homologous chromosome segregation#GO:0045143;cellular component organization or biogenesis#GO:0071840 condensed chromosome#GO:0000793;membraneless organelle#GO:0043228;condensed nuclear chromosome#GO:0000794;synaptonemal complex#GO:0000795;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;synaptonemal structure#GO:0099086;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;central element#GO:0000801;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;chromosome#GO:0005694;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=11018|UniProtKB=Q9H598 Q9H598 SLC32A1 PTHR48017:SF206 OS05G0424000 PROTEIN-RELATED VESICULAR INHIBITORY AMINO ACID TRANSPORTER glycine transmembrane transporter activity#GO:0015187;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;transporter activity#GO:0005215;neutral L-amino acid transmembrane transporter activity#GO:0015175;amino acid transmembrane transporter activity#GO:0015171 glycine transport#GO:0015816;cellular localization#GO:0051641;neutral amino acid transport#GO:0015804;localization#GO:0051179;carboxylic acid transport#GO:0046942;transport#GO:0006810;organic acid transport#GO:0015849;amino acid transport#GO:0006865;synaptic vesicle cycle#GO:0099504;establishment of localization#GO:0051234;vesicle-mediated transport in synapse#GO:0099003;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;nitrogen compound transport#GO:0071705;neurotransmitter transport#GO:0006836;vesicle-mediated transport#GO:0016192 vesicle membrane#GO:0012506;membrane#GO:0016020;transport vesicle#GO:0030133;endomembrane system#GO:0012505;transport vesicle membrane#GO:0030658;somatodendritic compartment#GO:0036477;organelle membrane#GO:0031090;vesicle#GO:0031982;synaptic vesicle membrane#GO:0030672;synaptic vesicle#GO:0008021;neuron projection terminus#GO:0044306;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;dendrite#GO:0030425;dendritic tree#GO:0097447;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;secretory vesicle#GO:0099503;presynapse#GO:0098793;neuron projection#GO:0043005;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;cell junction#GO:0030054;bounding membrane of organelle#GO:0098588;intracellular vesicle#GO:0097708;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382 HUMAN|HGNC=14406|UniProtKB=Q9H3S7 Q9H3S7 PTPN23 PTHR23030:SF45 PCD6 INTERACTING PROTEIN-RELATED TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 23 intracellular transport#GO:0046907;transport#GO:0006810;vacuolar transport#GO:0007034;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;establishment of protein localization to organelle#GO:0072594;ubiquitin-dependent protein catabolic process#GO:0006511;vesicle-mediated transport to the plasma membrane#GO:0098876;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;multivesicular body sorting pathway#GO:0071985;early endosome to late endosome transport#GO:0045022;late endosome to vacuole transport via multivesicular body sorting pathway#GO:0032511;ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043162;endosome transport via multivesicular body sorting pathway#GO:0032509;protein localization to vacuole#GO:0072665;localization within membrane#GO:0051668;protein metabolic process#GO:0019538;localization#GO:0051179;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;protein localization to organelle#GO:0033365;catabolic process#GO:0009056;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;intracellular protein transport#GO:0006886;endosomal transport#GO:0016197;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;vesicle-mediated transport#GO:0016192;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;cellular localization#GO:0051641;protein transport#GO:0015031;establishment of protein localization to vacuole#GO:0072666;endocytic recycling#GO:0032456;protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043328;late endosome to vacuole transport#GO:0045324 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;intracellular organelle#GO:0043229 membrane traffic protein#PC00150 HUMAN|HGNC=5009|UniProtKB=P52926 P52926 HMGA2 PTHR23341:SF4 HIGH MOBILITY GROUP PROTEINS HMG-A AND C HIGH MOBILITY GROUP PROTEIN HMGI-C transcription coregulator activity#GO:0003712;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;DNA binding#GO:0003677 intracellular signal transduction#GO:0035556;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signaling#GO:0023052;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;response to stimulus#GO:0050896;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 HMG box transcription factor#PC00024 HUMAN|HGNC=25773|UniProtKB=Q9H967 Q9H967 WDR76 PTHR14773:SF0 WD REPEAT-CONTAINING PROTEIN 76 WD REPEAT-CONTAINING PROTEIN 76 nucleic acid binding#GO:0003676;binding#GO:0005488;DNA binding#GO:0003677 regulation of cell cycle process#GO:0010564;biological regulation#GO:0065007;regulation of cell cycle#GO:0051726;regulation of signal transduction#GO:0009966;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of cell cycle phase transition#GO:1901987;regulation of cellular response to stress#GO:0080135;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;regulation of response to stress#GO:0080134;regulation of intracellular signal transduction#GO:1902531 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;heterochromatin#GO:0000792;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694 HUMAN|HGNC=32472|UniProtKB=Q49A33 Q49A33 ZNF876P PTHR24384:SF201 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED ZINC FINGER PROTEIN 100-RELATED RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA-binding transcription factor#PC00218 HUMAN|HGNC=24965|UniProtKB=Q96AY2 Q96AY2 EME1 PTHR21077:SF7 EME1 PROTEIN STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT EME1 nuclear division#GO:0000280;cellular response to stress#GO:0033554;reciprocal meiotic recombination#GO:0007131;DNA-templated DNA replication#GO:0006261;mitotic intra-S DNA damage checkpoint signaling#GO:0031573;negative regulation of mitotic cell cycle#GO:0045930;negative regulation of biological process#GO:0048519;negative regulation of cell cycle phase transition#GO:1901988;cellular component organization#GO:0016043;meiosis I#GO:0007127;meiotic cell cycle process#GO:1903046;signal transduction in response to DNA damage#GO:0042770;regulation of biological process#GO:0050789;cell cycle process#GO:0022402;response to stimulus#GO:0050896;signaling#GO:0023052;regulation of cell cycle#GO:0051726;metabolic process#GO:0008152;meiotic cell cycle#GO:0051321;DNA metabolic process#GO:0006259;DNA recombination#GO:0006310;cellular component organization or biogenesis#GO:0071840;negative regulation of cell cycle#GO:0045786;double-strand break repair#GO:0006302;organelle organization#GO:0006996;response to stress#GO:0006950;signal transduction#GO:0007165;cellular process#GO:0009987;cell cycle checkpoint signaling#GO:0000075;regulation of cell cycle process#GO:0010564;meiosis I cell cycle process#GO:0061982;sexual reproduction#GO:0019953;cell communication#GO:0007154;organelle fission#GO:0048285;intracellular signal transduction#GO:0035556;cell cycle#GO:0007049;regulation of cell cycle phase transition#GO:1901987;mitotic cell cycle checkpoint signaling#GO:0007093;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;reciprocal homologous recombination#GO:0140527;mitotic DNA damage checkpoint signaling#GO:0044773;cellular response to stimulus#GO:0051716;DNA replication#GO:0006260;mitotic cell cycle#GO:0000278;regulation of cellular process#GO:0050794;reproductive process#GO:0022414;homologous recombination#GO:0035825;DNA repair#GO:0006281;negative regulation of cellular process#GO:0048523;DNA damage response#GO:0006974;negative regulation of cell cycle process#GO:0010948;macromolecule metabolic process#GO:0043170;meiotic nuclear division#GO:0140013;mitotic cell cycle process#GO:1903047;DNA integrity checkpoint signaling#GO:0031570;resolution of meiotic recombination intermediates#GO:0000712;mitotic DNA integrity checkpoint signaling#GO:0044774;regulation of mitotic cell cycle#GO:0007346;DNA damage checkpoint signaling#GO:0000077;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;replication fork processing#GO:0031297 protein-containing complex#GO:0032991;intracellular protein-containing complex#GO:0140535;endonuclease complex#GO:1905348;catalytic complex#GO:1902494 HUMAN|HGNC=10622|UniProtKB=P55773 P55773 CCL23 PTHR12015:SF157 SMALL INDUCIBLE CYTOKINE A C-C MOTIF CHEMOKINE 23 cytokine activity#GO:0005125;signaling receptor binding#GO:0005102;binding#GO:0005488;cytokine receptor binding#GO:0005126;molecular function activator activity#GO:0140677;chemokine receptor binding#GO:0042379;protein binding#GO:0005515;chemokine activity#GO:0008009;G protein-coupled receptor binding#GO:0001664;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772 cell surface receptor signaling pathway#GO:0007166;humoral immune response#GO:0006959;antimicrobial humoral response#GO:0019730;positive regulation of biological process#GO:0048518;defense response to symbiont#GO:0140546;signal transduction#GO:0007165;cellular process#GO:0009987;response to chemokine#GO:1990868;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;taxis#GO:0042330;response to cytokine#GO:0034097;response to chemical#GO:0042221;granulocyte migration#GO:0097530;defense response to other organism#GO:0098542;G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887;immune system process#GO:0002376;response to peptide#GO:1901652;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;positive regulation of cell motility#GO:2000147;biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052;granulocyte chemotaxis#GO:0071621;response to stimulus#GO:0050896;regulation of cell migration#GO:0030334;leukocyte migration#GO:0050900;response to external stimulus#GO:0009605;positive regulation of locomotion#GO:0040017;myeloid leukocyte migration#GO:0097529;leukocyte chemotaxis#GO:0030595;defense response#GO:0006952;immune response#GO:0006955;positive regulation of cellular process#GO:0048522;positive regulation of cell migration#GO:0030335;biological regulation#GO:0065007;response to other organism#GO:0051707;regulation of locomotion#GO:0040012;cell migration#GO:0016477;chemotaxis#GO:0006935;inflammatory response#GO:0006954;cytokine-mediated signaling pathway#GO:0019221;cell chemotaxis#GO:0060326;regulation of cell motility#GO:2000145;chemokine-mediated signaling pathway#GO:0070098;cell communication#GO:0007154;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;cellular response to stimulus#GO:0051716;response to external biotic stimulus#GO:0043207;locomotion#GO:0040011;cellular response to chemokine#GO:1990869;cell motility#GO:0048870;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 cytokine#PC00083 HUMAN|HGNC=16805|UniProtKB=Q2TBC4 Q2TBC4 PRICKLE4 PTHR24214:SF34 PDZ AND LIM DOMAIN PROTEIN ZASP PRICKLE-LIKE PROTEIN 4 binding#GO:0005488;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515 multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;animal organ development#GO:0048513;developmental process#GO:0032502;cytoskeleton organization#GO:0007010;heart development#GO:0007507;multicellular organismal process#GO:0032501;cellular process#GO:0009987;organelle organization#GO:0006996;system development#GO:0048731;anatomical structure development#GO:0048856;actin filament-based process#GO:0030029;animal gross anatomical part developmental process#GO:0160108;circulatory system development#GO:0072359;actin cytoskeleton organization#GO:0030036;muscle structure development#GO:0061061;cellular component organization#GO:0016043 supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;cell-cell junction#GO:0005911;contractile muscle fiber#GO:0043292;actomyosin#GO:0042641;Z disc#GO:0030018;sarcomere#GO:0030017;cell junction#GO:0030054;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;adherens junction#GO:0005912;stress fiber#GO:0001725;cytoskeleton#GO:0005856;I band#GO:0031674;actin filament#GO:0005884;organelle#GO:0043226;cellular anatomical structure#GO:0110165;actin cytoskeleton#GO:0015629;actin filament bundle#GO:0032432;myofibril#GO:0030016;supramolecular fiber#GO:0099512;anchoring junction#GO:0070161;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=30761|UniProtKB=Q8NDW8 Q8NDW8 TTC21A PTHR14699:SF2 STI2 PROTEIN-RELATED TETRATRICOPEPTIDE REPEAT PROTEIN 21A cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;cilium movement involved in cell motility#GO:0060294;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;cellular localization#GO:0051641;cilium-dependent cell motility#GO:0060285;cilium organization#GO:0044782;spermatid differentiation#GO:0048515;cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;microtubule-based transport#GO:0099111;gamete generation#GO:0007276;intraciliary retrograde transport#GO:0035721;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cellular process involved in reproduction in multicellular organism#GO:0022412;cell development#GO:0048468;cellular component organization#GO:0016043;sperm motility#GO:0097722;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;cellular developmental process#GO:0048869;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;flagellated sperm motility#GO:0030317;transport#GO:0006810;developmental process#GO:0032502;spermatogenesis#GO:0007283;cytoskeleton-dependent intracellular transport#GO:0030705;male gamete generation#GO:0048232;plasma membrane bounded cell projection organization#GO:0120036;macromolecule localization#GO:0033036;anatomical structure development#GO:0048856;localization#GO:0051179;multicellular organismal reproductive process#GO:0048609;spermatid development#GO:0007286;sexual reproduction#GO:0019953;microtubule-based movement#GO:0007018;cell motility#GO:0048870;protein localization to organelle#GO:0033365;reproductive process#GO:0022414;intraciliary transport#GO:0042073;protein localization to cilium#GO:0061512;developmental process involved in reproduction#GO:0003006;germ cell development#GO:0007281 intraciliary transport particle#GO:0030990;intraciliary transport particle A#GO:0030991;protein-containing complex#GO:0032991 HUMAN|HGNC=25904|UniProtKB=Q5T4D3 Q5T4D3 TMTC4 PTHR44227:SF3 FAMILY NOT NAMED PROTEIN O-MANNOSYL-TRANSFERASE TMTC4 mannosyltransferase activity#GO:0000030;glycosyltransferase activity#GO:0016757;hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740 response to unfolded protein#GO:0006986;cell communication#GO:0007154;protein metabolic process#GO:0019538;intracellular signal transduction#GO:0035556;response to endoplasmic reticulum stress#GO:0034976;cellular response to unfolded protein#GO:0034620;protein O-linked glycosylation via mannose#GO:0035269;cellular response to stress#GO:0033554;cellular response to topologically incorrect protein#GO:0035967;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;response to topologically incorrect protein#GO:0035966;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;biosynthetic process#GO:0009058;biological regulation#GO:0065007;glycoprotein biosynthetic process#GO:0009101;endoplasmic reticulum unfolded protein response#GO:0030968;response to stress#GO:0006950;carbohydrate derivative metabolic process#GO:1901135;signal transduction#GO:0007165;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein O-linked glycosylation#GO:0006493 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=25224|UniProtKB=Q5VT98 Q5VT98 PRAMEF20 PTHR14224:SF93 SIMILAR TO PREFERENTIALLY EXPRESSED ANTIGEN IN MELANOMA-LIKE 3 PRAME FAMILY MEMBER 20 enzyme-substrate adaptor activity#GO:0140767;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;cullin-RING ubiquitin ligase complex#GO:0031461;ubiquitin ligase complex#GO:0000151;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;Cul2-RING ubiquitin ligase complex#GO:0031462;transferase complex#GO:1990234;catalytic complex#GO:1902494 HUMAN|HGNC=18359|UniProtKB=Q8IW75 Q8IW75 SERPINA12 PTHR11461:SF157 SERINE PROTEASE INHIBITOR, SERPIN SERPIN A12 enzyme inhibitor activity#GO:0004857;molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866;peptidase regulator activity#GO:0061134;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;serine-type endopeptidase inhibitor activity#GO:0004867;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease inhibitor#PC00191 HUMAN|HGNC=25762|UniProtKB=Q969V5 Q969V5 MUL1 PTHR12183:SF4 MITOCHONDRIAL UBIQUITIN LIGASE ACTIVATOR OF NFKB 1 MITOCHONDRIAL UBIQUITIN LIGASE ACTIVATOR OF NFKB 1 catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;SUMO ligase activity#GO:0061665;SUMO transferase activity#GO:0019789;ubiquitin-like protein transferase activity#GO:0019787 biological regulation#GO:0065007;positive regulation of biological process#GO:0048518;regulation of protein stability#GO:0031647;positive regulation of cellular process#GO:0048522;regulation of anatomical structure morphogenesis#GO:0022603;protein stabilization#GO:0050821;positive regulation of developmental process#GO:0051094;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;positive regulation of mitochondrial fission#GO:0090141;regulation of mitochondrial fission#GO:0090140;regulation of developmental process#GO:0050793;regulation of biological process#GO:0050789;regulation of mitochondrion organization#GO:0010821;regulation of organelle organization#GO:0033043;positive regulation of organelle organization#GO:0010638;regulation of biological quality#GO:0065008;positive regulation of cellular component organization#GO:0051130 mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=44164|UniProtKB=A6NF83 A6NF83 NUPR2 PTHR17149:SF3 NUCLEAR PROTEIN 1 AND 2 NUCLEAR PROTEIN 2 regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cell cycle#GO:0051726;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of cell population proliferation#GO:0042127;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;negative regulation of cell population proliferation#GO:0008285;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biosynthetic process#GO:0009889;negative regulation of cell cycle#GO:0045786;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=6341|UniProtKB=Q15726 Q15726 KISS1 PTHR16955:SF6 METASTASIS-SUPPRESSOR KISS-1 METASTASIS-SUPPRESSOR KISS-1 G protein-coupled receptor binding#GO:0001664;neuropeptide receptor binding#GO:0071855;signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515 regulation of localization#GO:0032879;regulation of transport#GO:0051049;regulation of system process#GO:0044057;biological regulation#GO:0065007;regulation of multicellular organismal process#GO:0051239;positive regulation of transport#GO:0051050;positive regulation of secretion by cell#GO:1903532;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165;cellular process#GO:0009987;cell communication#GO:0007154;regulation of hormone secretion#GO:0046883;regulation of secretion#GO:0051046;positive regulation of signaling#GO:0023056;regulation of secretion by cell#GO:1903530;regulation of biological quality#GO:0065008;G protein-coupled receptor signaling pathway#GO:0007186;positive regulation of hormone secretion#GO:0046887;positive regulation of secretion#GO:0051047;regulation of signaling#GO:0023051;response to stimulus#GO:0050896;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of cell communication#GO:0010646;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;positive regulation of multicellular organismal process#GO:0051240;regulation of hormone levels#GO:0010817 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=24783|UniProtKB=Q3SXY7 Q3SXY7 LRIT3 PTHR45842:SF8 SYNAPTIC ADHESION-LIKE MOLECULE SALM LEUCINE-RICH REPEAT, IMMUNOGLOBULIN-LIKE DOMAIN AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 3 immunoglobulin superfamily cell adhesion molecule#PC00125;cell adhesion molecule#PC00069 HUMAN|HGNC=20099|UniProtKB=Q8WUH1 Q8WUH1 CHURC1 PTHR31931:SF2 PROTEIN CHURCHILL PROTEIN CHURCHILL biological regulation#GO:0065007;fibroblast growth factor receptor signaling pathway#GO:0008543;signal transduction#GO:0007165;cellular response to fibroblast growth factor stimulus#GO:0044344;cellular process#GO:0009987;cell surface receptor signaling pathway#GO:0007166;response to fibroblast growth factor#GO:0071774;signaling#GO:0023052;cellular response to endogenous stimulus#GO:0071495;response to growth factor#GO:0070848;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to endogenous stimulus#GO:0009719;cellular response to growth factor stimulus#GO:0071363;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169 HUMAN|HGNC=18068|UniProtKB=Q8IY34 Q8IY34 SLC15A3 PTHR11654:SF95 OLIGOPEPTIDE TRANSPORTER-RELATED SOLUTE CARRIER FAMILY 15 MEMBER 3 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;oligopeptide transmembrane transporter activity#GO:0035673;dipeptide transmembrane transporter activity#GO:0071916 localization#GO:0051179;dipeptide transport#GO:0042938;transmembrane transport#GO:0055085;import into cell#GO:0098657;establishment of localization#GO:0051234;oligopeptide transport#GO:0006857;transport#GO:0006810;import across plasma membrane#GO:0098739;peptide transport#GO:0015833;nitrogen compound transport#GO:0071705;oligopeptide transmembrane transport#GO:0035672;cellular process#GO:0009987 organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;lytic vacuole#GO:0000323;vacuolar membrane#GO:0005774;vacuole#GO:0005773;cytoplasm#GO:0005737;lysosomal membrane#GO:0005765;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;lysosome#GO:0005764;lytic vacuole membrane#GO:0098852 transporter#PC00227 HUMAN|HGNC=21684|UniProtKB=Q96JM2 Q96JM2 ZNF462 PTHR24403:SF58 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 462 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=21728|UniProtKB=Q8IU81 Q8IU81 IRF2BP1 PTHR10816:SF17 MYELIN TRANSCRIPTION FACTOR 1-RELATED INTERFERON REGULATORY FACTOR 2-BINDING PROTEIN 1 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 gene-specific transcriptional regulator#PC00264;zinc finger transcription factor#PC00244 HUMAN|HGNC=9312|UniProtKB=Q14738 Q14738 PPP2R5D PTHR10257:SF89 SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT DELTA ISOFORM enzyme activator activity#GO:0008047;protein phosphatase regulator activity#GO:0019888;phosphatase activator activity#GO:0019211;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;phosphatase regulator activity#GO:0019208;enzyme regulator activity#GO:0030234 organelle organization#GO:0006996;cell cycle#GO:0007049;cellular component organization#GO:0016043;cell cycle process#GO:0022402;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;sister chromatid cohesion#GO:0007062;meiotic sister chromatid cohesion#GO:0051177;chromosome organization#GO:0051276 protein serine/threonine phosphatase complex#GO:0008287;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 protein phosphatase#PC00195;protein modifying enzyme#PC00260 Wnt signaling pathway#P00057>PP2A#P01438;FGF signaling pathway#P00021>PP2A#P00629;EGF receptor signaling pathway#P00018>PP2A#P00547 HUMAN|HGNC=17330|UniProtKB=Q9NUL7 Q9NUL7 DDX28 PTHR24031:SF421 RNA HELICASE ATP-DEPENDENT RNA HELICASE DDX28-RELATED cellular component assembly#GO:0022607;ribosomal large subunit assembly#GO:0000027;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;protein-RNA complex organization#GO:0071826;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;mitochondrial ribosome assembly#GO:0061668;ribonucleoprotein complex biogenesis#GO:0022613;mitochondrial large ribosomal subunit assembly#GO:1902775;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;protein-RNA complex assembly#GO:0022618;ribosome biogenesis#GO:0042254;organelle assembly#GO:0070925;ribosome assembly#GO:0042255;ribosomal large subunit biogenesis#GO:0042273 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739 RNA metabolism protein#PC00031;RNA helicase#PC00032 HUMAN|HGNC=20153|UniProtKB=Q9HCK8 Q9HCK8 CHD8 PTHR45623:SF3 CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED ATP-DEPENDENT CHROMATIN REMODELER CHD8 ATP-dependent activity, acting on DNA#GO:0008094;protein binding#GO:0005515;ATP-dependent activity#GO:0140657;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;catalytic activity, acting on DNA#GO:0140097;hydrolase activity, acting on acid anhydrides#GO:0016817;ATP hydrolysis activity#GO:0016887;DNA binding#GO:0003677;hydrolase activity#GO:0016787;chromatin binding#GO:0003682;nucleic acid binding#GO:0003676;ribonucleoside triphosphate phosphatase activity#GO:0017111;histone binding#GO:0042393;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;pyrophosphatase activity#GO:0016462 regulation of cell communication#GO:0010646;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;chromatin organization#GO:0006325;regulation of signal transduction#GO:0009966;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;tube development#GO:0035295;brain development#GO:0007420;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of Wnt signaling pathway#GO:0030178;negative regulation of response to stimulus#GO:0048585;multicellular organismal process#GO:0032501;developmental process#GO:0032502;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;regulation of Wnt signaling pathway#GO:0030111;central nervous system development#GO:0007417;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;negative regulation of canonical Wnt signaling pathway#GO:0090090;animal gross anatomical part developmental process#GO:0160108;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of cell communication#GO:0010648;negative regulation of DNA-templated transcription#GO:0045892;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of canonical Wnt signaling pathway#GO:0060828;head development#GO:0060322;negative regulation of signal transduction#GO:0009968;nervous system development#GO:0007399;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;animal organ development#GO:0048513 catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;methyltransferase complex#GO:0034708;organelle#GO:0043226;nucleoplasm#GO:0005654;histone methyltransferase complex#GO:0035097;transferase complex#GO:1990234;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;chromatin#GO:0000785;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=20627|UniProtKB=Q9UDX3 Q9UDX3 SEC14L4 PTHR23324:SF42 SEC14 RELATED PROTEIN SEC14-LIKE PROTEIN 4 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 transfer/carrier protein#PC00219 HUMAN|HGNC=10485|UniProtKB=Q15413 Q15413 RYR3 PTHR46399:SF9 B30.2/SPRY DOMAIN-CONTAINING PROTEIN RYANODINE RECEPTOR 3 gated channel activity#GO:0022836;ligand-gated calcium channel activity#GO:0099604;calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873;ligand-gated monoatomic ion channel activity#GO:0015276;channel activity#GO:0015267;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;ligand-gated monoatomic cation channel activity#GO:0099094;monoatomic cation channel activity#GO:0005261 striated muscle contraction#GO:0006941;metal ion transport#GO:0030001;muscle system process#GO:0003012;calcium ion transmembrane transport#GO:0070588;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;release of sequestered calcium ion into cytosol by sarcoplasmic reticulum#GO:0014808;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;multicellular organismal process#GO:0032501;release of sequestered calcium ion into cytosol#GO:0051209;cellular process#GO:0009987;calcium ion transport#GO:0006816;system process#GO:0003008;calcium ion transmembrane import into cytosol#GO:0097553;establishment of localization#GO:0051234;transport#GO:0006810;muscle contraction#GO:0006936 monoatomic ion channel complex#GO:0034702;endomembrane system#GO:0012505;plasma membrane#GO:0005886;membrane#GO:0016020;Z disc#GO:0030018;cell periphery#GO:0071944;sarcolemma#GO:0042383;membraneless organelle#GO:0043228;organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;I band#GO:0031674;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;transmembrane transporter complex#GO:1902495;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;sarcoplasm#GO:0016528;endoplasmic reticulum subcompartment#GO:0098827;supramolecular complex#GO:0099080;sarcoplasmic reticulum membrane#GO:0033017;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;sarcoplasmic reticulum#GO:0016529;contractile muscle fiber#GO:0043292;sarcomere#GO:0030017;transporter complex#GO:1990351;bounding membrane of organelle#GO:0098588;cation channel complex#GO:0034703;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;calcium channel complex#GO:0034704;myofibril#GO:0030016;supramolecular fiber#GO:0099512;organelle subcompartment#GO:0031984;intracellular organelle#GO:0043229 CCKR signaling map#P06959>RYR1/2/3#P07088;Beta2 adrenergic receptor signaling pathway#P04378>ER-type Ca2+ channel#P04441;Beta1 adrenergic receptor signaling pathway#P04377>ER-type Ca2+ channel#P04434 HUMAN|HGNC=29663|UniProtKB=Q1L6U9 Q1L6U9 MSMP PTHR10500:SF4 BETA-MICROSEMINOPROTEIN PROSTATE-ASSOCIATED MICROSEMINOPROTEIN extracellular region#GO:0005576;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 intercellular signal molecule#PC00207 HUMAN|HGNC=39035|UniProtKB=P61565 P61565 ERVK-21 PTHR34313:SF3 ENDOGENOUS RETROVIRUS GROUP K MEMBER 113 ENV POLYPROTEIN-RELATED ENDOGENOUS RETROVIRUS GROUP K MEMBER 113 ENV POLYPROTEIN-RELATED viral or transposable element protein#PC00237 HUMAN|HGNC=13973|UniProtKB=Q96KW2 Q96KW2 POM121L2 PTHR23193:SF20 NUCLEAR PORE COMPLEX PROTEIN NUP POM121-LIKE PROTEIN 2 structural molecule activity#GO:0005198;structural constituent of nuclear pore#GO:0017056;nucleocytoplasmic carrier activity#GO:0140142;molecular carrier activity#GO:0140104 establishment of RNA localization#GO:0051236;nucleobase-containing compound transport#GO:0015931;RNA transport#GO:0050658;protein localization to organelle#GO:0033365;RNA localization#GO:0006403;nuclear transport#GO:0051169;protein transport#GO:0015031;nuclear export#GO:0051168;protein import into nucleus#GO:0006606;localization#GO:0051179;nucleic acid transport#GO:0050657;cellular localization#GO:0051641;nucleocytoplasmic transport#GO:0006913;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;import into nucleus#GO:0051170;macromolecule localization#GO:0033036;nitrogen compound transport#GO:0071705;protein localization to nucleus#GO:0034504;intracellular protein localization#GO:0008104;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear pore#GO:0005643;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;organelle envelope#GO:0031967 transporter#PC00227 HUMAN|HGNC=16691|UniProtKB=Q9UGJ1 Q9UGJ1 TUBGCP4 PTHR19302:SF27 GAMMA TUBULIN COMPLEX PROTEIN GAMMA-TUBULIN COMPLEX COMPONENT 4 protein binding#GO:0005515;microtubule binding#GO:0008017;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631 membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;cell cycle#GO:0007049;microtubule nucleation#GO:0007020;cell cycle process#GO:0022402;protein polymerization#GO:0051258;protein-containing complex assembly#GO:0065003;cytoplasmic microtubule organization#GO:0031122;mitotic cell cycle#GO:0000278;reproductive process#GO:0022414;organelle assembly#GO:0070925;sexual reproduction#GO:0019953;microtubule cytoskeleton organization#GO:0000226;supramolecular fiber organization#GO:0097435;spindle assembly#GO:0051225;microtubule polymerization or depolymerization#GO:0031109;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;meiotic cell cycle#GO:0051321;chromosome segregation#GO:0007059;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;microtubule polymerization#GO:0046785;protein-containing complex organization#GO:0043933;microtubule-based process#GO:0007017 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 non-motor microtubule binding protein#PC00166;cytoskeletal protein#PC00085 HUMAN|HGNC=3954|UniProtKB=Q14331 Q14331 FRG1 PTHR12928:SF3 FRG1 PROTEIN PROTEIN FRG1 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;spliceosomal complex#GO:0005681;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;nucleolus#GO:0005730;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;nuclear protein-containing complex#GO:0140513;catalytic step 2 spliceosome#GO:0071013;membraneless organelle#GO:0043228 RNA splicing factor#PC00148 HUMAN|HGNC=18193|UniProtKB=Q9NY93 Q9NY93 DDX56 PTHR24031:SF781 RNA HELICASE ATP-DEPENDENT RNA HELICASE DDX56-RELATED macromolecule biosynthetic process#GO:0009059;response to other organism#GO:0051707;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;maturation of LSU-rRNA#GO:0000470;rRNA metabolic process#GO:0016072;defense response#GO:0006952;response to external stimulus#GO:0009605;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;response to external biotic stimulus#GO:0043207;rRNA processing#GO:0006364;response to virus#GO:0009615;cellular process#GO:0009987;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;cellular component biogenesis#GO:0044085;RNA processing#GO:0006396;gene expression#GO:0010467;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;defense response to virus#GO:0051607;ribonucleoprotein complex biogenesis#GO:0022613;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;ribosomal large subunit biogenesis#GO:0042273;RNA metabolic process#GO:0016070 nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 RNA helicase#PC00032;RNA metabolism protein#PC00031 HUMAN|HGNC=3232|UniProtKB=O75095 O75095 MEGF6 PTHR24035:SF137 MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN 6 phagocytosis#GO:0006909;transport#GO:0006810;membrane invagination#GO:0010324;import into cell#GO:0098657;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;apoptotic cell clearance#GO:0043277;localization#GO:0051179;phagocytosis, engulfment#GO:0006911;cellular component organization#GO:0016043;cellular process#GO:0009987;endocytosis#GO:0006897;membrane organization#GO:0061024 extracellular matrix protein#PC00102 HUMAN|HGNC=28530|UniProtKB=Q8TAV0 Q8TAV0 FAM76A PTHR46176:SF2 LD21662P PROTEIN FAM76A intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear speck#GO:0016607;organelle lumen#GO:0043233;membraneless organelle#GO:0043228;nuclear body#GO:0016604;intracellular membraneless organelle#GO:0043232;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974 HUMAN|HGNC=9919|UniProtKB=P09455 P09455 RBP1 PTHR11955:SF56 FATTY ACID BINDING PROTEIN RETINOL-BINDING PROTEIN 1 alcohol binding#GO:0043178;organic acid binding#GO:0043177;ion binding#GO:0043167;carboxylic acid binding#GO:0031406;anion binding#GO:0043168;binding#GO:0005488;small molecule binding#GO:0036094;lipid binding#GO:0008289;fatty acid binding#GO:0005504 establishment of localization#GO:0051234;localization#GO:0051179;fatty acid transport#GO:0015908;monocarboxylic acid transport#GO:0015718;lipid localization#GO:0010876;organic acid transport#GO:0015849;transport#GO:0006810;carboxylic acid transport#GO:0046942;lipid transport#GO:0006869;macromolecule localization#GO:0033036 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 transfer/carrier protein#PC00219 HUMAN|HGNC=19129|UniProtKB=Q9Y617 Q9Y617 PSAT1 PTHR43247:SF5 PHOSPHOSERINE AMINOTRANSFERASE PHOSPHOSERINE AMINOTRANSFERASE heterocyclic compound binding#GO:1901363;transferase activity#GO:0016740;catalytic activity#GO:0003824;binding#GO:0005488;anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167;transaminase activity#GO:0008483 small molecule biosynthetic process#GO:0044283;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;amino acid biosynthetic process#GO:0008652;proteinogenic amino acid biosynthetic process#GO:0170038;carboxylic acid biosynthetic process#GO:0046394;cellular process#GO:0009987;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;small molecule metabolic process#GO:0044281;proteinogenic amino acid metabolic process#GO:0170039 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 transaminase#PC00216 Vitamin B6 metabolism#P02787>Phosphoserine transaminase#P03227;Serine glycine biosynthesis#P02776>Phosphoserine aminotransferase#P03157;Pyridoxal-5-phosphate biosynthesis#P02759>Phosphohydroxythreonine aminotransferase#P03058 HUMAN|HGNC=26916|UniProtKB=Q92802 Q92802 N4BP2L2 PTHR13308:SF23 NEDD4-BINDING PROTEIN 2-LIKE 1 NEDD4-BINDING PROTEIN 2-LIKE 2 transcription regulator activity#GO:0140110;transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;negative regulation of metabolic process#GO:0009892;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=13764|UniProtKB=Q969Z4 Q969Z4 RELT PTHR47397:SF1 TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 19L TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 19L odontogenesis of dentin-containing tooth#GO:0042475;animal organ morphogenesis#GO:0009887;odontogenesis#GO:0042476;programmed cell death#GO:0012501;anatomical structure morphogenesis#GO:0009653;cellular process#GO:0009987;apoptotic process#GO:0006915;amelogenesis#GO:0097186;cell death#GO:0008219;anatomical structure development#GO:0048856;animal organ development#GO:0048513;anatomical structure formation involved in morphogenesis#GO:0048646;animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502 transmembrane signal receptor#PC00197 HUMAN|HGNC=9863|UniProtKB=Q13702 Q13702 RAPSN PTHR46574:SF1 43 KDA RECEPTOR-ASSOCIATED PROTEIN OF THE SYNAPSE 43 KDA RECEPTOR-ASSOCIATED PROTEIN OF THE SYNAPSE signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515 chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;anterograde trans-synaptic signaling#GO:0098916;regulation of cell communication#GO:0010646;modulation of chemical synaptic transmission#GO:0050804;signaling#GO:0023052;trans-synaptic signaling#GO:0099537;positive regulation of synaptic transmission#GO:0050806;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;cell communication#GO:0007154;synaptic signaling#GO:0099536;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of trans-synaptic signaling#GO:0099177;synaptic transmission, cholinergic#GO:0007271;cell-cell signaling#GO:0007267;biological regulation#GO:0065007 plasma membrane#GO:0005886;synapse#GO:0045202;neuromuscular junction#GO:0031594;cellular anatomical structure#GO:0110165;cell junction#GO:0030054;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=26314|UniProtKB=Q96LW2 Q96LW2 RSKR PTHR24355:SF1 G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE RIBOSOMAL PROTEIN S6 KINASE-RELATED PROTEIN phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;protein kinase activity#GO:0004672;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=193|UniProtKB=Q13444 Q13444 ADAM15 PTHR11905:SF130 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 15 cell adhesion molecule binding#GO:0050839;catalytic activity#GO:0003824;metalloendopeptidase activity#GO:0004222;integrin binding#GO:0005178;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;metallopeptidase activity#GO:0008237;binding#GO:0005488;signaling receptor binding#GO:0005102;protein-containing complex binding#GO:0044877;hydrolase activity#GO:0016787;protein binding#GO:0005515 defense response to other organism#GO:0098542;biological regulation#GO:0065007;response to other organism#GO:0051707;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;signal transduction#GO:0007165;defense response to symbiont#GO:0140546;immune response#GO:0006955;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;innate immune response#GO:0045087;response to external stimulus#GO:0009605;defense response#GO:0006952;metabolic process#GO:0008152;cell surface receptor signaling pathway#GO:0007166;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052;response to external biotic stimulus#GO:0043207;primary metabolic process#GO:0044238;integrin-mediated signaling pathway#GO:0007229;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;protein metabolic process#GO:0019538;proteolysis#GO:0006508;immune system process#GO:0002376 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metalloprotease#PC00153;protease#PC00190 HUMAN|HGNC=9185|UniProtKB=Q9NP87 Q9NP87 POLM PTHR11276:SF24 DNA POLYMERASE TYPE-X FAMILY MEMBER DNA-DIRECTED DNA_RNA POLYMERASE MU DNA-directed DNA polymerase activity#GO:0003887;transferase activity, transferring phosphorus-containing groups#GO:0016772;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on DNA#GO:0140097;DNA polymerase activity#GO:0034061 DNA damage response#GO:0006974;cellular response to stress#GO:0033554;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;double-strand break repair#GO:0006302;double-strand break repair via nonhomologous end joining#GO:0006303;macromolecule metabolic process#GO:0043170;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;primary metabolic process#GO:0044238;response to stress#GO:0006950;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound metabolic process#GO:0006139;response to stimulus#GO:0050896 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 DNA metabolism protein#PC00009;DNA-directed DNA polymerase#PC00018 HUMAN|HGNC=20479|UniProtKB=Q8IUB3 Q8IUB3 WFDC10B PTHR19441:SF17 WAP four-disulfide core domain protein PROTEIN WFDC10B endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414;peptidase regulator activity#GO:0061134;enzyme regulator activity#GO:0030234;serine-type endopeptidase inhibitor activity#GO:0004867;molecular function inhibitor activity#GO:0140678;enzyme inhibitor activity#GO:0004857;endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772 response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;defense response to bacterium#GO:0042742;response to bacterium#GO:0009617;immune system process#GO:0002376;response to other organism#GO:0051707;defense response to other organism#GO:0098542;immune response#GO:0006955;defense response to symbiont#GO:0140546;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;defense response#GO:0006952;response to external stimulus#GO:0009605;innate immune response#GO:0045087;antibacterial humoral response#GO:0019731;antimicrobial humoral response#GO:0019730;humoral immune response#GO:0006959 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease inhibitor#PC00191 HUMAN|HGNC=15974|UniProtKB=Q9C040 Q9C040 TRIM2 PTHR24104:SF58 E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED TRIPARTITE MOTIF-CONTAINING PROTEIN 2 aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746 macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein modification by small protein conjugation or removal#GO:0070647;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;catabolic process#GO:0009056;primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein polyubiquitination#GO:0000209;modification-dependent protein catabolic process#GO:0019941;protein modification by small protein conjugation#GO:0032446;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein ubiquitination#GO:0016567;proteasomal protein catabolic process#GO:0010498;post-translational protein modification#GO:0043687;cellular process#GO:0009987 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 Alzheimer disease-presenilin pathway#P00004>HAC1#P00131 HUMAN|HGNC=19185|UniProtKB=Q86XX4 Q86XX4 FRAS1 PTHR45739:SF1 MATRIX PROTEIN, PUTATIVE-RELATED EXTRACELLULAR MATRIX ORGANIZING PROTEIN FRAS1 cellular process#GO:0009987;homeostatic process#GO:0042592;epithelial structure maintenance#GO:0010669;anatomical structure homeostasis#GO:0060249;multicellular organismal process#GO:0032501;cell-matrix adhesion#GO:0007160;cell adhesion#GO:0007155;multicellular organismal-level homeostasis#GO:0048871;tissue homeostasis#GO:0001894;cell-substrate adhesion#GO:0031589 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012 HUMAN|HGNC=6936|UniProtKB=Q96RQ3 Q96RQ3 MCCC1 PTHR18866:SF33 CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL catalytic activity#GO:0003824;ligase activity#GO:0016874 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 ligase#PC00142;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=12154|UniProtKB=A0A087WT02 A0A087WT02 TRAV9-2 PTHR19367:SF43 T-CELL RECEPTOR ALPHA CHAIN V REGION T CELL RECEPTOR ALPHA VARIABLE 9-2 immune system process#GO:0002376;immune response#GO:0006955;response to stimulus#GO:0050896;adaptive immune response#GO:0002250 protein-containing complex#GO:0032991 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=8515|UniProtKB=Q9HC10 Q9HC10 OTOF PTHR12546:SF32 FER-1-LIKE OTOFERLIN metal ion binding#GO:0046872;cation binding#GO:0043169;protein-containing complex binding#GO:0044877;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;calcium ion binding#GO:0005509 signal release from synapse#GO:0099643;chemical synaptic transmission#GO:0007268;anterograde trans-synaptic signaling#GO:0098916;sensory perception of mechanical stimulus#GO:0050954;sensory perception#GO:0007600;trans-synaptic signaling#GO:0099537;signal release#GO:0023061;secretion#GO:0046903;localization#GO:0051179;cell communication#GO:0007154;response to mechanical stimulus#GO:0009612;neurotransmitter secretion#GO:0007269;cell-cell signaling#GO:0007267;membrane organization#GO:0061024;biological regulation#GO:0065007;synaptic vesicle recycling#GO:0036465;multicellular organismal process#GO:0032501;transport#GO:0006810;synaptic vesicle cycle#GO:0099504;response to external stimulus#GO:0009605;system process#GO:0003008;establishment of localization#GO:0051234;regulation of biological process#GO:0050789;protein-containing complex assembly#GO:0065003;response to abiotic stimulus#GO:0009628;cellular component organization#GO:0016043;signaling#GO:0023052;export from cell#GO:0140352;response to stimulus#GO:0050896;sensory perception of sound#GO:0007605;nervous system process#GO:0050877;secretion by cell#GO:0032940;cellular localization#GO:0051641;plasma membrane organization#GO:0007009;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;synaptic vesicle exocytosis#GO:0016079;synaptic signaling#GO:0099536;cellular component biogenesis#GO:0044085;endomembrane system organization#GO:0010256;neurotransmitter transport#GO:0006836;vesicle-mediated transport#GO:0016192;cellular component assembly#GO:0022607;exocytic process#GO:0140029;regulated exocytosis#GO:0045055;protein-containing complex organization#GO:0043933;exocytosis#GO:0006887;vesicle-mediated transport in synapse#GO:0099003;cellular component organization or biogenesis#GO:0071840 presynapse#GO:0098793;secretory vesicle#GO:0099503;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;synaptic membrane#GO:0097060;bounding membrane of organelle#GO:0098588;cell junction#GO:0030054;presynaptic active zone#GO:0048786;intracellular vesicle#GO:0097708;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;cell periphery#GO:0071944;vesicle membrane#GO:0012506;membrane#GO:0016020;plasma membrane#GO:0005886;presynaptic membrane#GO:0042734;transport vesicle#GO:0030133;plasma membrane region#GO:0098590;endomembrane system#GO:0012505;transport vesicle membrane#GO:0030658;organelle membrane#GO:0031090;vesicle#GO:0031982;synaptic vesicle membrane#GO:0030672;synaptic vesicle#GO:0008021;presynaptic active zone membrane#GO:0048787;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410 membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=1363|UniProtKB=Q9H330 Q9H330 TMEM245 PTHR21716:SF4 TRANSMEMBRANE PROTEIN TRANSMEMBRANE PROTEIN 245 cellular process#GO:0009987;transport#GO:0006810;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;organic hydroxy compound transport#GO:0015850 membrane#GO:0016020;cellular anatomical structure#GO:0110165 HUMAN|HGNC=9713|UniProtKB=P40855 P40855 PEX19 PTHR12774:SF2 PEROXISOMAL BIOGENESIS FACTOR 19 PEROXISOMAL BIOGENESIS FACTOR 19 signal sequence receptor activity#GO:0005048 cellular localization#GO:0051641;localization#GO:0051179;peroxisomal transport#GO:0043574;protein transport#GO:0015031;peroxisome organization#GO:0007031;localization within membrane#GO:0051668;protein localization to organelle#GO:0033365;cellular component organization#GO:0016043;protein localization to membrane#GO:0072657;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;establishment of protein localization to organelle#GO:0072594;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;transport#GO:0006810;intracellular protein transport#GO:0006886;macromolecule localization#GO:0033036;organelle organization#GO:0006996;establishment of protein localization to membrane#GO:0090150;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649 bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;peroxisomal membrane#GO:0005778;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;peroxisome#GO:0005777;microbody#GO:0042579 membrane traffic protein#PC00150 HUMAN|HGNC=20961|UniProtKB=Q92625 Q92625 ANKS1A PTHR24174:SF4 ANKYRIN REPEAT AND STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 1 ANKYRIN REPEAT AND SAM DOMAIN-CONTAINING PROTEIN 1A protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;ephrin receptor signaling pathway#GO:0048013;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cell surface receptor signaling pathway#GO:0007166 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=9868|UniProtKB=Q99969 Q99969 RARRES2 PTHR15106:SF2 RETINOIC ACID RECEPTOR RESPONDER PROTEIN 2 RETINOIC ACID RECEPTOR RESPONDER PROTEIN 2 binding#GO:0005488;signaling receptor binding#GO:0005102;protein binding#GO:0005515 regulation of primary metabolic process#GO:0080090;response to biotic stimulus#GO:0009607;regulation of metabolic process#GO:0019222;response to stress#GO:0006950;defense response to symbiont#GO:0140546;positive regulation of biological process#GO:0048518;immune response#GO:0006955;positive regulation of response to stimulus#GO:0048584;regulation of response to external stimulus#GO:0032101;defense response to other organism#GO:0098542;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;response to other organism#GO:0051707;regulation of response to stimulus#GO:0048583;positive regulation of response to external stimulus#GO:0032103;innate immune response#GO:0045087;positive regulation of locomotion#GO:0040017;response to external stimulus#GO:0009605;defense response#GO:0006952;regulation of catabolic process#GO:0009894;regulation of chemotaxis#GO:0050920;regulation of biological process#GO:0050789;regulation of lipid catabolic process#GO:0050994;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;immune system process#GO:0002376;regulation of lipid metabolic process#GO:0019216;positive regulation of chemotaxis#GO:0050921 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 HUMAN|HGNC=28969|UniProtKB=Q14154 Q14154 DELE1 PTHR45011:SF1 DAP3-BINDING CELL DEATH ENHANCER 1 DAP3-BINDING CELL DEATH ENHANCER 1 enzyme activator activity#GO:0008047;protein serine/threonine kinase activator activity#GO:0043539;protein kinase activator activity#GO:0030295;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;protein kinase regulator activity#GO:0019887;kinase activator activity#GO:0019209;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677 signaling#GO:0023052;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stress#GO:0006950;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;cellular response to stress#GO:0033554 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=18168|UniProtKB=Q9BY07 Q9BY07 SLC4A5 PTHR11453:SF20 ANION EXCHANGE PROTEIN ELECTROGENIC SODIUM BICARBONATE COTRANSPORTER 4 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;bicarbonate transmembrane transporter activity#GO:0015106;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294;symporter activity#GO:0015293;monoatomic cation transmembrane transporter activity#GO:0008324;solute:sodium symporter activity#GO:0015370 regulation of biological quality#GO:0065008;transmembrane transport#GO:0055085;localization#GO:0051179;regulation of intracellular pH#GO:0051453;regulation of pH#GO:0006885;homeostatic process#GO:0042592;intracellular monoatomic ion homeostasis#GO:0006873;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;system process#GO:0003008;establishment of localization#GO:0051234;chemical homeostasis#GO:0048878;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;renal system process#GO:0003014;cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801 cell periphery#GO:0071944;basal plasma membrane#GO:0009925;membrane#GO:0016020;basal part of cell#GO:0045178;basolateral plasma membrane#GO:0016323;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590 secondary carrier transporter#PC00258 HUMAN|HGNC=4077|UniProtKB=P34903 P34903 GABRA3 PTHR18945:SF216 NEUROTRANSMITTER GATED ION CHANNEL GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-3 channel activity#GO:0015267;molecular transducer activity#GO:0060089;gated channel activity#GO:0022836;transmembrane signaling receptor activity#GO:0004888;ligand-gated monoatomic ion channel activity#GO:0015276;signaling receptor activity#GO:0038023;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion transmembrane transporter activity#GO:0015075;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;monoatomic ion channel activity#GO:0005216;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;neurotransmitter receptor activity#GO:0030594 chloride transport#GO:0006821;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;synaptic signaling#GO:0099536;nervous system development#GO:0007399;cellular component assembly#GO:0022607;monoatomic anion transmembrane transport#GO:0098656;animal gross anatomical part developmental process#GO:0160108;inorganic anion transport#GO:0015698;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;regulation of biological process#GO:0050789;cell junction assembly#GO:0034329;cellular component organization#GO:0016043;signaling#GO:0023052;synapse assembly#GO:0007416;developmental process#GO:0032502;transport#GO:0006810;establishment of localization#GO:0051234;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;monoatomic ion transmembrane transport#GO:0034220;multicellular organismal process#GO:0032501;synapse organization#GO:0050808;trans-synaptic signaling#GO:0099537;system development#GO:0048731;cell communication#GO:0007154;chloride transmembrane transport#GO:1902476;localization#GO:0051179;anatomical structure development#GO:0048856;monoatomic anion transport#GO:0006820;chemical synaptic transmission#GO:0007268;anterograde trans-synaptic signaling#GO:0098916;cell junction organization#GO:0034330 cell periphery#GO:0071944;neuron projection#GO:0043005;membrane#GO:0016020;cell leading edge#GO:0031252;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;plasma membrane region#GO:0098590;signaling receptor complex#GO:0043235;neuron projection membrane#GO:0032589;cell junction#GO:0030054;postsynapse#GO:0098794;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;synapse#GO:0045202;cellular anatomical structure#GO:0110165;leading edge membrane#GO:0031256;dendritic tree#GO:0097447;dendrite#GO:0030425;cell projection membrane#GO:0031253 ligand-gated ion channel#PC00141 HUMAN|HGNC=11033|UniProtKB=Q9Y6M7 Q9Y6M7 SLC4A7 PTHR11453:SF105 ANION EXCHANGE PROTEIN SODIUM BICARBONATE COTRANSPORTER 3 metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;bicarbonate transmembrane transporter activity#GO:0015106;monoatomic cation transmembrane transporter activity#GO:0008324;solute:sodium symporter activity#GO:0015370;symporter activity#GO:0015293 inner ear development#GO:0048839;biological regulation#GO:0065007;epidermal cell differentiation#GO:0009913;epithelial cell differentiation#GO:0030855;tissue development#GO:0009888;multicellular organismal process#GO:0032501;epithelium development#GO:0060429;transport#GO:0006810;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;developmental process#GO:0032502;epidermis development#GO:0008544;sensory organ development#GO:0007423;neurogenesis#GO:0022008;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;establishment of localization#GO:0051234;cellular developmental process#GO:0048869;homeostatic process#GO:0042592;regulation of intracellular pH#GO:0051453;regulation of pH#GO:0006885;system development#GO:0048731;anatomical structure development#GO:0048856;localization#GO:0051179;cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801;hair cell differentiation#GO:0035315;nervous system development#GO:0007399;chemical homeostasis#GO:0048878;neuron differentiation#GO:0030182;animal organ development#GO:0048513;multicellular organism development#GO:0007275;intracellular monoatomic ion homeostasis#GO:0006873;cell development#GO:0048468;cell differentiation#GO:0030154;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;regulation of biological quality#GO:0065008;ear development#GO:0043583;neuron development#GO:0048666;transmembrane transport#GO:0055085 apical part of cell#GO:0045177;basolateral plasma membrane#GO:0016323;basal part of cell#GO:0045178;apical plasma membrane#GO:0016324;membrane#GO:0016020;basal plasma membrane#GO:0009925;cell periphery#GO:0071944;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 secondary carrier transporter#PC00258 HUMAN|HGNC=14592|UniProtKB=Q7Z628 Q7Z628 NET1 PTHR46006:SF4 RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A NEUROEPITHELIAL CELL-TRANSFORMING GENE 1 PROTEIN regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789;regulation of Rho protein signal transduction#GO:0035023;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of cell communication#GO:0010646;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;regulation of small GTPase mediated signal transduction#GO:0051056;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of response to stimulus#GO:0048584;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007 protein-binding activity modulator#PC00095;G-protein modulator#PC00022;guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=29426|UniProtKB=Q6UXH8 Q6UXH8 CCBE1 PTHR24034:SF76 EGF-LIKE DOMAIN-CONTAINING PROTEIN COLLAGEN AND CALCIUM-BINDING EGF DOMAIN-CONTAINING PROTEIN 1 circulatory system development#GO:0072359;multicellular organismal process#GO:0032501;anatomical structure morphogenesis#GO:0009653;multicellular organism development#GO:0007275;anatomical structure development#GO:0048856;system development#GO:0048731;vasculature development#GO:0001944;anatomical structure formation involved in morphogenesis#GO:0048646;animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HUMAN|HGNC=10606|UniProtKB=P22307 P22307 SCP2 PTHR24314:SF20 NON-SPECIFIC LIPID TRANSFER PROTEIN-RELATED STEROL CARRIER PROTEIN 2 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;peroxisome#GO:0005777;microbody#GO:0042579 transfer/carrier protein#PC00219 HUMAN|HGNC=29626|UniProtKB=Q8TDS7 Q8TDS7 MRGPRD PTHR11334:SF57 MAS-RELATED G-PROTEIN COUPLED RECEPTOR MAS-RELATED G PROTEIN-COUPLED RECEPTOR MEMBER D cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=3971|UniProtKB=P19883 P19883 FST PTHR10913:SF6 FOLLISTATIN-RELATED FOLLISTATIN protein-containing complex binding#GO:0044877;binding#GO:0005488;activin binding#GO:0048185 cellular developmental process#GO:0048869;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;developmental process#GO:0032502;negative regulation of response to stimulus#GO:0048585;negative regulation of signal transduction#GO:0009968;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cellular response to growth factor stimulus#GO:0090287;regulation of BMP signaling pathway#GO:0030510;cellular process#GO:0009987;negative regulation of cell communication#GO:0010648;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of cell communication#GO:0010646;negative regulation of biological process#GO:0048519;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092;regulation of biological process#GO:0050789 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease inhibitor#PC00191 Gonadotropin-releasing hormone receptor pathway#P06664>Follistatin#G06671;Gonadotropin-releasing hormone receptor pathway#P06664>Follistatin#P06835;Gonadotropin-releasing hormone receptor pathway#P06664>Follistatin#G06885 HUMAN|HGNC=30232|UniProtKB=Q7Z422 Q7Z422 SZRD1 PTHR31796:SF4 SUZ DOMAIN-CONTAINING PROTEIN 1 SUZ RNA-BINDING DOMAIN-CONTAINING HUMAN|HGNC=24051|UniProtKB=Q6ZN18 Q6ZN18 AEBP2 PTHR46541:SF1 ZINC FINGER PROTEIN AEBP2 ZINC FINGER PROTEIN AEBP2 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 organelle lumen#GO:0043233;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;methyltransferase complex#GO:0034708;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;PcG protein complex#GO:0031519;nucleus#GO:0005634;protein-containing complex#GO:0032991;histone methyltransferase complex#GO:0035097;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513 HUMAN|HGNC=21904|UniProtKB=Q86XI2 Q86XI2 NCAPG2 PTHR16199:SF4 CONDENSIN-2 COMPLEX SUBUNIT G2 CONDENSIN-2 COMPLEX SUBUNIT G2 organelle organization#GO:0006996;mitotic sister chromatid segregation#GO:0000070;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;chromosome organization#GO:0051276;mitotic cell cycle process#GO:1903047;chromosome segregation#GO:0007059;mitotic cell cycle#GO:0000278;cellular component organization#GO:0016043;sister chromatid segregation#GO:0000819;nuclear chromosome segregation#GO:0098813;cell cycle#GO:0007049;mitotic nuclear division#GO:0140014;cell cycle process#GO:0022402;organelle fission#GO:0048285;nuclear division#GO:0000280 condensin complex#GO:0000796;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;nucleus#GO:0005634;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=8331|UniProtKB=Q8NGR4 Q8NGR4 OR5C1 PTHR26452:SF119 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5C1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 system process#GO:0003008;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;sensory perception#GO:0007600;nervous system process#GO:0050877;sensory perception of chemical stimulus#GO:0007606 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=6138|UniProtKB=P08514 P08514 ITGA2B PTHR23220:SF73 INTEGRIN ALPHA INTEGRIN ALPHA-IIB molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 signaling#GO:0023052;regulation of cellular process#GO:0050794;circulatory system development#GO:0072359;response to stimulus#GO:0050896;tube morphogenesis#GO:0035239;blood vessel development#GO:0001568;cellular response to stimulus#GO:0051716;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;blood vessel morphogenesis#GO:0048514;integrin-mediated signaling pathway#GO:0007229;system development#GO:0048731;anatomical structure development#GO:0048856;angiogenesis#GO:0001525;cell-substrate adhesion#GO:0031589;cell communication#GO:0007154;cell adhesion#GO:0007155;cell-matrix adhesion#GO:0007160;animal gross anatomical part developmental process#GO:0160108;tube development#GO:0035295;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;cellular process#GO:0009987;signal transduction#GO:0007165;cell-cell adhesion#GO:0098609;anatomical structure formation involved in morphogenesis#GO:0048646;vasculature development#GO:0001944;multicellular organism development#GO:0007275;cell surface receptor signaling pathway#GO:0007166;developmental process#GO:0032502 integrin complex#GO:0008305;signaling receptor complex#GO:0043235;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cell surface#GO:0009986;plasma membrane#GO:0005886;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;protein complex involved in cell adhesion#GO:0098636;cell periphery#GO:0071944 integrin#PC00126;cell adhesion molecule#PC00069 Blood coagulation#P00011>GP IIb#P00410;Integrin signalling pathway#P00034>Integrin alpha#P00941 HUMAN|HGNC=5031|UniProtKB=P09651 P09651 HNRNPA1 PTHR48026:SF2 HOMOLOGOUS TO DROSOPHILA SQD (SQUID) PROTEIN HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A1 mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723;mRNA 3'-UTR binding#GO:0003730 mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;catalytic step 2 spliceosome#GO:0071013;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ribonucleoprotein complex#GO:1990904;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;spliceosomal complex#GO:0005681 RNA metabolism protein#PC00031;RNA processing factor#PC00147 HUMAN|HGNC=19046|UniProtKB=Q9H2Y9 Q9H2Y9 SLCO5A1 PTHR11388:SF142 ORGANIC ANION TRANSPORTER SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 5A1 active transmembrane transporter activity#GO:0022804;secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 transport#GO:0006810;cellular process#GO:0009987;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179 plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;basal part of cell#GO:0045178;basolateral plasma membrane#GO:0016323;membrane#GO:0016020;basal plasma membrane#GO:0009925;cell periphery#GO:0071944 transporter#PC00227 HUMAN|HGNC=16718|UniProtKB=Q9H6R0 Q9H6R0 DHX33 PTHR18934:SF118 ATP-DEPENDENT RNA HELICASE ATP-DEPENDENT RNA HELICASE DHX33 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;double-stranded RNA binding#GO:0003725;ATP-dependent activity#GO:0140657;helicase activity#GO:0004386;isomerase activity#GO:0016853;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;macromolecular conformation isomerase activity#GO:0120543 regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;regulation of transcription by RNA polymerase I#GO:0006356;regulation of DNA-templated transcription#GO:0006355;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of transcription by RNA polymerase I#GO:0045943;positive regulation of RNA biosynthetic process#GO:1902680;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231 RNA metabolism protein#PC00031;RNA helicase#PC00032 HUMAN|Ensembl=ENSG00000282822.1|UniProtKB=A0A0J9YW62 A0A0J9YW62 PTHR23266:SF273 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN V-SET DOMAIN-CONTAINING PROTEIN binding#GO:0005488;antigen binding#GO:0003823 immune response#GO:0006955;response to stimulus#GO:0050896;adaptive immune response#GO:0002250;immune system process#GO:0002376;immune effector process#GO:0002252;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449;immunoglobulin mediated immune response#GO:0016064;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=10497|UniProtKB=P31151 P31151 S100A7 PTHR11639:SF128 S100 CALCIUM-BINDING PROTEIN PROTEIN S100-A7 ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;calcium ion binding#GO:0005509;protein binding#GO:0005515;metal ion binding#GO:0046872;cation binding#GO:0043169 cellular process#GO:0009987;cell motility#GO:0048870;cell migration#GO:0016477;endothelial cell migration#GO:0043542 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 calcium-binding protein#PC00060;calmodulin-related#PC00061 HUMAN|HGNC=25974|UniProtKB=Q9HCC8 Q9HCC8 GDPD2 PTHR23344:SF1 GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE 3 phosphoric ester hydrolase activity#GO:0042578;phosphoric diester hydrolase activity#GO:0008081;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 metabolite interconversion enzyme#PC00262;phosphodiesterase#PC00185 HUMAN|HGNC=23095|UniProtKB=Q8WUG5 Q8WUG5 SLC22A17 PTHR24064:SF216 SOLUTE CARRIER FAMILY 22 MEMBER SOLUTE CARRIER FAMILY 22 MEMBER 17 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 metal ion transport#GO:0030001;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;localization#GO:0051179;transition metal ion transport#GO:0000041;transport#GO:0006810;iron ion transport#GO:0006826;iron coordination entity transport#GO:1901678 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 secondary carrier transporter#PC00258 HUMAN|HGNC=20061|UniProtKB=Q9P2H5 Q9P2H5 USP35 PTHR24006:SF660 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 35 hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;cysteine-type deubiquitinase activity#GO:0004843 biological regulation#GO:0065007;regulation of biological quality#GO:0065008;regulation of protein stability#GO:0031647 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;cytosol#GO:0005829 protease#PC00190;cysteine protease#PC00081 HUMAN|HGNC=33482|UniProtKB=A1L020 A1L020 MEX3A PTHR23285:SF2 RING FINGER AND KH DOMAIN CONTAINING PROTEIN 1 RNA-BINDING PROTEIN MEX3A RNA metabolism protein#PC00031 HUMAN|HGNC=536|UniProtKB=P27216 P27216 ANXA13 PTHR10502:SF175 ANNEXIN ANNEXIN A13 lipid binding#GO:0008289;phosphatidylserine binding#GO:0001786;binding#GO:0005488;small molecule binding#GO:0036094;phospholipid binding#GO:0005543;anion binding#GO:0043168;ion binding#GO:0043167 membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;vesicle membrane#GO:0012506;membrane#GO:0016020;vesicle#GO:0031982;nucleus#GO:0005634;cell periphery#GO:0071944 calcium-binding protein#PC00060 HUMAN|HGNC=33772|UniProtKB=Q0VGL1 Q0VGL1 LAMTOR4 PTHR33967:SF1 RAGULATOR COMPLEX PROTEIN LAMTOR4 RAGULATOR COMPLEX PROTEIN LAMTOR4 enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;response to chemical#GO:0042221;positive regulation of response to stimulus#GO:0048584;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;response to acid chemical#GO:0001101;cellular process#GO:0009987;regulation of TOR signaling#GO:0032006;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;regulation of cell communication#GO:0010646;response to stimulus#GO:0050896;cellular response to amino acid stimulus#GO:0071230;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;positive regulation of TOR signaling#GO:0032008;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;cellular response to chemical stimulus#GO:0070887;regulation of intracellular signal transduction#GO:1902531 vacuolar membrane#GO:0005774;lytic vacuole#GO:0000323;bounding membrane of organelle#GO:0098588;intracellular protein-containing complex#GO:0140535;organelle membrane#GO:0031090;membrane#GO:0016020;protein-containing complex#GO:0032991;guanyl-nucleotide exchange factor complex#GO:0032045;cytoplasm#GO:0005737;vacuole#GO:0005773;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane protein complex#GO:0098796;lysosome#GO:0005764;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=12641|UniProtKB=Q9UBK9 Q9UBK9 UXT PTHR13345:SF15 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 10 PROTEIN UXT transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714;transcription regulator activity#GO:0140110 intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;mediator complex#GO:0016592;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031;general transcription factor#PC00259 HUMAN|HGNC=30386|UniProtKB=Q8TAC9 Q8TAC9 SCAMP5 PTHR10687:SF5 SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN SCAMP SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN 5 cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;export from cell#GO:0140352;transport#GO:0006810;establishment of localization#GO:0051234;secretion#GO:0046903;localization#GO:0051179;exocytosis#GO:0006887;secretion by cell#GO:0032940 Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;vesicle membrane#GO:0012506;trans-Golgi network membrane#GO:0032588;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;recycling endosome#GO:0055037;Golgi apparatus#GO:0005794;recycling endosome membrane#GO:0055038;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;endosome membrane#GO:0010008;endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984 transfer/carrier protein#PC00219 HUMAN|HGNC=1542|UniProtKB=Q13191 Q13191 CBLB PTHR23007:SF3 CBL E3 UBIQUITIN-PROTEIN LIGASE CBL-B transferase activity#GO:0016740;protein binding#GO:0005515;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;kinase binding#GO:0019900;binding#GO:0005488;enzyme binding#GO:0019899;ubiquitin protein ligase activity#GO:0061630;protein kinase binding#GO:0019901;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;receptor tyrosine kinase binding#GO:0030971;signaling receptor binding#GO:0005102;protein tyrosine kinase binding#GO:1990782;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787 negative regulation of response to stimulus#GO:0048585;negative regulation of signal transduction#GO:0009968;regulation of epidermal growth factor receptor signaling pathway#GO:0042058;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;cellular process#GO:0009987;signal transduction#GO:0007165;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of cell communication#GO:0010646;signaling#GO:0023052;negative regulation of biological process#GO:0048519;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of ERBB signaling pathway#GO:1901184;cell communication#GO:0007154;negative regulation of cell communication#GO:0010648;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051 membrane microdomain#GO:0098857;cell periphery#GO:0071944;membrane raft#GO:0045121;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ligase#PC00142 EGF receptor signaling pathway#P00018>c-Cbl#P00544 HUMAN|HGNC=33276|UniProtKB=Q5D862 Q5D862 FLG2 PTHR22571:SF24 FILAGGRIN-RELATED FILAGGRIN-2 epithelium development#GO:0060429;tissue development#GO:0009888;skin development#GO:0043588;animal gross anatomical part developmental process#GO:0160108;epidermis development#GO:0008544;developmental process#GO:0032502;animal organ development#GO:0048513;anatomical structure development#GO:0048856 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;cell periphery#GO:0071944 cytoskeletal protein#PC00085 HUMAN|HGNC=18700|UniProtKB=Q9NQI0 Q9NQI0 DDX4 PTHR47958:SF205 ATP-DEPENDENT RNA HELICASE DBP3 ATP-DEPENDENT RNA HELICASE DDX4-RELATED binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;ATP-dependent activity#GO:0140657;RNA binding#GO:0003723;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;RNA helicase activity#GO:0003724;nucleic acid conformation isomerase activity#GO:0120545;macromolecular conformation isomerase activity#GO:0120543;helicase activity#GO:0004386;isomerase activity#GO:0016853;catalytic activity, acting on RNA#GO:0140098 cell differentiation#GO:0030154;gamete generation#GO:0007276;cell development#GO:0048468;reproductive process#GO:0022414;cellular process involved in reproduction in multicellular organism#GO:0022412;developmental process involved in reproduction#GO:0003006;germ cell development#GO:0007281;cellular process#GO:0009987;anatomical structure development#GO:0048856;cellular developmental process#GO:0048869;multicellular organismal reproductive process#GO:0048609;sexual reproduction#GO:0019953;developmental process#GO:0032502 nucleus#GO:0005634;ribonucleoprotein granule#GO:0035770;organelle#GO:0043226;supramolecular complex#GO:0099080;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;P granule#GO:0043186 RNA helicase#PC00032 HUMAN|HGNC=2542|UniProtKB=P43234 P43234 CTSO PTHR12411:SF992 CYSTEINE PROTEASE FAMILY C1-RELATED CATHEPSIN O hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;cysteine-type endopeptidase activity#GO:0004197;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;catabolic process#GO:0009056;cellular process#GO:0009987;primary metabolic process#GO:0044238 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;vacuole#GO:0005773;extracellular region#GO:0005576;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 protease#PC00190;cysteine protease#PC00081;protein modifying enzyme#PC00260 HUMAN|HGNC=8576|UniProtKB=Q15102 Q15102 PAFAH1B3 PTHR11852:SF2 PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE IB SUBUNIT ALPHA1 acetyltransferase activity#GO:0016407;acyltransferase activity#GO:0016746;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;transferase activity#GO:0016740;hydrolase activity, acting on ester bonds#GO:0016788;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 multicellular organismal reproductive process#GO:0048609;developmental process#GO:0032502;sexual reproduction#GO:0019953;spermatogenesis#GO:0007283;gamete generation#GO:0007276;male gamete generation#GO:0048232;reproductive process#GO:0022414;developmental process involved in reproduction#GO:0003006 catalytic complex#GO:1902494;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260 HUMAN|HGNC=9179|UniProtKB=P54098 P54098 POLG PTHR10267:SF0 DNA POLYMERASE SUBUNIT GAMMA-1 DNA POLYMERASE SUBUNIT GAMMA-1 DNA exonuclease activity#GO:0004529;transferase activity#GO:0016740;3'-5' exonuclease activity#GO:0008408;DNA polymerase activity#GO:0034061;catalytic activity, acting on DNA#GO:0140097;exonuclease activity#GO:0004527;3'-5'-DNA exonuclease activity#GO:0008296;DNA exonuclease activity, producing 5'-phosphomonoesters#GO:0016895;nuclease activity#GO:0004518;DNA nuclease activity#GO:0004536;transferase activity, transferring phosphorus-containing groups#GO:0016772;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;DNA-directed DNA polymerase activity#GO:0003887;hydrolase activity#GO:0016787 DNA metabolic process#GO:0006259;metabolic process#GO:0008152;mitochondrial DNA metabolic process#GO:0032042;macromolecule metabolic process#GO:0043170;DNA-templated DNA replication#GO:0006261;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;DNA replication#GO:0006260;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;mitochondrion#GO:0005739;intracellular protein-containing complex#GO:0140535;DNA polymerase complex#GO:0042575;transferase complex#GO:1990234;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;cytoplasm#GO:0005737;membrane-enclosed lumen#GO:0031974 DNA-directed DNA polymerase#PC00018 HUMAN|HGNC=27396|UniProtKB=Q68DD2 Q68DD2 PLA2G4F PTHR10728:SF22 CYTOSOLIC PHOSPHOLIPASE A2 CYTOSOLIC PHOSPHOLIPASE A2 ZETA metal ion binding#GO:0046872;lipid binding#GO:0008289;binding#GO:0005488;calcium ion binding#GO:0005509;A2-type glycerophospholipase activity#GO:0004623;glycerophospholipase activity#GO:0004620;phospholipase activity#GO:0120569;hydrolase activity#GO:0016787;cation binding#GO:0043169;small molecule binding#GO:0036094;lipase activity#GO:0016298;ion binding#GO:0043167;carboxylic ester hydrolase activity#GO:0052689;catalytic activity#GO:0003824;phospholipid binding#GO:0005543;hydrolase activity, acting on ester bonds#GO:0016788 organophosphate catabolic process#GO:0046434;glycerophospholipid catabolic process#GO:0046475;metabolic process#GO:0008152;glycerolipid catabolic process#GO:0046503;lipid metabolic process#GO:0006629;catabolic process#GO:0009056;glycerolipid metabolic process#GO:0046486;phospholipid catabolic process#GO:0009395;glycerophospholipid metabolic process#GO:0006650;phospholipid metabolic process#GO:0006644;organophosphate metabolic process#GO:0019637;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;lipid catabolic process#GO:0016042;cellular process#GO:0009987 ruffle membrane#GO:0032587;ruffle#GO:0001726;membrane#GO:0016020;cell leading edge#GO:0031252;cytosol#GO:0005829;cell periphery#GO:0071944;plasma membrane region#GO:0098590;cytoplasm#GO:0005737;plasma membrane#GO:0005886;leading edge membrane#GO:0031256;cell projection membrane#GO:0031253;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995 phospholipase#PC00186 HUMAN|HGNC=14422|UniProtKB=Q8WY36 Q8WY36 BBX PTHR13059:SF10 HMG-BOX TRANSCRIPTION FACTOR BBX HMG BOX TRANSCRIPTION FACTOR BBX sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 HMG box transcription factor#PC00024;DNA-binding transcription factor#PC00218 HUMAN|HGNC=29002|UniProtKB=O14526 O14526 FCHO1 PTHR23065:SF6 PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1 F-BAR DOMAIN ONLY PROTEIN 1 cellular process#GO:0009987;clathrin-dependent endocytosis#GO:0072583;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;cellular component assembly#GO:0022607;transport#GO:0006810;protein-containing complex organization#GO:0043933;receptor-mediated endocytosis#GO:0006898;import into cell#GO:0098657;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;localization#GO:0051179 clathrin-coated vesicle#GO:0030136;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;coated vesicle#GO:0030135;vesicle#GO:0031982;clathrin-coated pit#GO:0005905;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 actin or actin-binding cytoskeletal protein#PC00041;cytoskeletal protein#PC00085 HUMAN|HGNC=29592|UniProtKB=Q8IXB3 Q8IXB3 TRARG1 PTHR14948:SF1 NG5 TRAFFICKING REGULATOR OF GLUT4 1 cellular response to peptide hormone stimulus#GO:0071375;protein localization to plasma membrane#GO:0072659;response to insulin#GO:0032868;cellular response to stimulus#GO:0051716;localization#GO:0051179;response to nitrogen compound#GO:1901698;localization within membrane#GO:0051668;establishment of protein localization to plasma membrane#GO:0061951;cellular response to nitrogen compound#GO:1901699;response to peptide hormone#GO:0043434;macromolecule localization#GO:0033036;endosome to plasma membrane protein transport#GO:0099638;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;vesicle-mediated transport to the plasma membrane#GO:0098876;intracellular transport#GO:0046907;transport#GO:0006810;cellular response to insulin stimulus#GO:0032869;response to stimulus#GO:0050896;endocytic recycling#GO:0032456;cellular response to endogenous stimulus#GO:0071495;cellular response to hormone stimulus#GO:0032870;protein localization to membrane#GO:0072657;response to endogenous stimulus#GO:0009719;cellular localization#GO:0051641;protein transport#GO:0015031;cellular response to chemical stimulus#GO:0070887;response to oxygen-containing compound#GO:1901700;response to chemical#GO:0042221;vesicle-mediated transport#GO:0016192;establishment of protein localization to membrane#GO:0090150;response to hormone#GO:0009725;establishment of localization in cell#GO:0051649;cellular response to oxygen-containing compound#GO:1901701;establishment of protein localization#GO:0045184;cellular process#GO:0009987;endosomal transport#GO:0016197;protein localization to cell periphery#GO:1990778;intracellular protein transport#GO:0006886 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;vesicle#GO:0031982;membrane#GO:0016020;intracellular vesicle#GO:0097708;vesicle membrane#GO:0012506;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cytoplasmic vesicle membrane#GO:0030659;cellular anatomical structure#GO:0110165;organelle#GO:0043226 scaffold/adaptor protein#PC00226 HUMAN|HGNC=13497|UniProtKB=O75346 O75346 ZNF253 PTHR24384:SF181 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED ZINC FINGER PROTEIN 253 binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218 HUMAN|HGNC=7945|UniProtKB=P17342 P17342 NPR3 PTHR44755:SF1 NATRIURETIC PEPTIDE RECEPTOR 3-RELATED ATRIAL NATRIURETIC PEPTIDE RECEPTOR 3 binding#GO:0005488;hormone binding#GO:0042562;signaling receptor activity#GO:0038023;peptide hormone binding#GO:0017046;peptide receptor activity#GO:0001653;molecular transducer activity#GO:0060089 cell communication#GO:0007154;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 transmembrane signal receptor#PC00197 HUMAN|HGNC=23097|UniProtKB=Q7RTT9 Q7RTT9 SLC29A4 PTHR10332:SF93 EQUILIBRATIVE NUCLEOSIDE TRANSPORTER EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 4 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoamine transmembrane transporter activity#GO:0008504;carbohydrate derivative transmembrane transporter activity#GO:1901505;active transmembrane transporter activity#GO:0022804;nucleoside transmembrane transporter activity#GO:0005337;nucleobase-containing compound transmembrane transporter activity#GO:0015932 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227 HUMAN|HGNC=8261|UniProtKB=O76001 O76001 OR2J3 PTHR26453:SF641 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2J3 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;response to chemical#GO:0042221;response to stimulus#GO:0050896;detection of chemical stimulus#GO:0009593;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;system process#GO:0003008;nervous system process#GO:0050877;sensory perception#GO:0007600;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=8800|UniProtKB=P01127 P01127 PDGFB PTHR11633:SF2 PLATELET-DERIVED GROWTH FACTOR PLATELET-DERIVED GROWTH FACTOR SUBUNIT B protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102;growth factor receptor binding#GO:0070851 positive regulation of response to stimulus#GO:0048584;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;positive regulation of cellular process#GO:0048522;positive regulation of cell migration#GO:0030335;positive regulation of MAPK cascade#GO:0043410;positive regulation of locomotion#GO:0040017;positive regulation of intracellular signal transduction#GO:1902533;regulation of cell migration#GO:0030334;regulation of response to stimulus#GO:0048583;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;positive regulation of ERK1 and ERK2 cascade#GO:0070374;regulation of cell communication#GO:0010646;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;regulation of cell population proliferation#GO:0042127;cell communication#GO:0007154;regulation of cell motility#GO:2000145;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051896;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of ERK1 and ERK2 cascade#GO:0070372;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of MAPK cascade#GO:0043408;cell surface receptor signaling pathway#GO:0007166;response to stimulus#GO:0050896;positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051897;signaling#GO:0023052;positive regulation of cell motility#GO:2000147;positive regulation of cell population proliferation#GO:0008284;regulation of biological process#GO:0050789;positive regulation of signaling#GO:0023056;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 growth factor#PC00112 Angiogenesis#P00005>PDGF#P00224;PDGF signaling pathway#P00047>PDGF#P01170 HUMAN|HGNC=17829|UniProtKB=Q9NPR9 Q9NPR9 GPR108 PTHR21229:SF11 LUNG SEVEN TRANSMEMBRANE RECEPTOR PROTEIN GPR108 negative regulation of cell communication#GO:0010648;negative regulation of signaling#GO:0023057;regulation of immune response#GO:0050776;regulation of signaling#GO:0023051;regulation of defense response#GO:0031347;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of response to biotic stimulus#GO:0002831;regulation of cell communication#GO:0010646;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of innate immune response#GO:0045088;negative regulation of cellular process#GO:0048523;regulation of response to stress#GO:0080134;regulation of response to stimulus#GO:0048583;regulation of response to external stimulus#GO:0032101;negative regulation of response to stimulus#GO:0048585;regulation of signal transduction#GO:0009966;negative regulation of immune system process#GO:0002683;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=6811|UniProtKB=O15481 O15481 MAGEB4 PTHR11736:SF162 MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN MELANOMA-ASSOCIATED ANTIGEN B4 negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=13875|UniProtKB=O15409 O15409 FOXP2 PTHR45796:SF9 FORKHEAD BOX P, ISOFORM C FORKHEAD BOX PROTEIN P2 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription repressor activity#GO:0001217 regulation of biosynthetic process#GO:0009889;animal organ development#GO:0048513;regulation of gene expression#GO:0010468;muscle organ development#GO:0007517;striated muscle tissue development#GO:0014706;developmental process#GO:0032502;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;tissue development#GO:0009888;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;skeletal muscle tissue development#GO:0007519;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;muscle tissue development#GO:0060537;regulation of RNA metabolic process#GO:0051252;skeletal muscle organ development#GO:0060538;animal gross anatomical part developmental process#GO:0160108;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;muscle structure development#GO:0061061;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246 HUMAN|HGNC=15873|UniProtKB=Q9GZN8 Q9GZN8 ADISSP PTHR13287:SF6 ADIPOSE-SECRETED SIGNALING PROTEIN ADIPOSE-SECRETED SIGNALING PROTEIN temperature homeostasis#GO:0001659;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;multicellular organismal-level homeostasis#GO:0048871;cellular process#GO:0009987;signal transduction#GO:0007165;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;adaptive thermogenesis#GO:1990845;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;homeostatic process#GO:0042592 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=10997|UniProtKB=Q5K4L6 Q5K4L6 SLC27A3 PTHR43107:SF12 LONG-CHAIN FATTY ACID TRANSPORT PROTEIN LONG-CHAIN FATTY ACID TRANSPORT PROTEIN 3 ligase activity, forming carbon-sulfur bonds#GO:0016877;carboxylic acid transmembrane transporter activity#GO:0046943;ATP-dependent activity#GO:0140657;monocarboxylic acid transmembrane transporter activity#GO:0008028;catalytic activity#GO:0003824;ligase activity#GO:0016874;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 lipid transport#GO:0006869;macromolecule localization#GO:0033036;long-chain fatty acid metabolic process#GO:0001676;cellular process#GO:0009987;establishment of localization#GO:0051234;import into cell#GO:0098657;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;carboxylic acid transport#GO:0046942;transport#GO:0006810;lipid metabolic process#GO:0006629;organic acid transport#GO:0015849;small molecule metabolic process#GO:0044281;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;fatty acid transport#GO:0015908;localization#GO:0051179;monocarboxylic acid transport#GO:0015718;lipid localization#GO:0010876;oxoacid metabolic process#GO:0043436 endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;organelle membrane#GO:0031090;membrane#GO:0016020;cell periphery#GO:0071944;endomembrane system#GO:0012505;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 secondary carrier transporter#PC00258 HUMAN|HGNC=9046|UniProtKB=Q9UM63 Q9UM63 PLAGL1 PTHR24399:SF31 ZINC FINGER AND BTB DOMAIN-CONTAINING ZINC FINGER PROTEIN PLAGL1 sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;DNA-binding transcription activator activity#GO:0001216;transcription regulator activity#GO:0140110;DNA-binding transcription repressor activity#GO:0001217;transcription regulatory region nucleic acid binding#GO:0001067 negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of cytokine production#GO:0001817;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of macromolecule metabolic process#GO:0010605 nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218 HUMAN|HGNC=29504|UniProtKB=Q401N2 Q401N2 ZACN PTHR18945:SF912 NEUROTRANSMITTER GATED ION CHANNEL LIGAND-GATED CATION CHANNEL ZACN molecular transducer activity#GO:0060089;channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation channel activity#GO:0005261;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;monoatomic cation transmembrane transporter activity#GO:0008324;transmembrane signaling receptor activity#GO:0004888;gated channel activity#GO:0022836;monoatomic ion transmembrane transporter activity#GO:0015075;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion channel activity#GO:0005216;signaling receptor activity#GO:0038023;neurotransmitter receptor activity#GO:0030594;transporter activity#GO:0005215 establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;calcium ion transport#GO:0006816;transport#GO:0006810;synaptic transmission, cholinergic#GO:0007271;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;monoatomic ion transmembrane transport#GO:0034220;synaptic signaling#GO:0099536;cellular process#GO:0009987;cell communication#GO:0007154;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;trans-synaptic signaling#GO:0099537;anterograde trans-synaptic signaling#GO:0098916;signaling#GO:0023052;metal ion transport#GO:0030001;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane protein complex#GO:0098796;membrane#GO:0016020;cell periphery#GO:0071944;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351 ligand-gated ion channel#PC00141 HUMAN|HGNC=1367|UniProtKB=Q96E40 Q96E40 SPACA9 PTHR32455:SF1 SPERM ACROSOME-ASSOCIATED PROTEIN 9 SPERM ACROSOME-ASSOCIATED PROTEIN 9 sperm flagellum#GO:0036126;endomembrane system#GO:0012505;cytoplasm#GO:0005737;secretory vesicle#GO:0099503;ciliary base#GO:0097546;motile cilium#GO:0031514;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;acrosomal vesicle#GO:0001669;9+2 motile cilium#GO:0097729;cilium#GO:0005929;intracellular organelle#GO:0043229 HUMAN|HGNC=24005|UniProtKB=A5X5Y0 A5X5Y0 HTR3E PTHR18945:SF764 NEUROTRANSMITTER GATED ION CHANNEL 5-HYDROXYTRYPTAMINE RECEPTOR 3E neurotransmitter receptor activity#GO:0030594;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion channel activity#GO:0005216;signaling receptor activity#GO:0038023;gated channel activity#GO:0022836;transmembrane signaling receptor activity#GO:0004888;monoatomic cation transmembrane transporter activity#GO:0008324;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261;ligand-gated monoatomic ion channel activity#GO:0015276;molecular transducer activity#GO:0060089;channel activity#GO:0015267 regulation of biological process#GO:0050789;signaling#GO:0023052;response to stimulus#GO:0050896;response to oxygen-containing compound#GO:1901700;cellular response to chemical stimulus#GO:0070887;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;transmembrane transport#GO:0055085;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;synaptic signaling#GO:0099536;response to chemical#GO:0042221;calcium ion transport#GO:0006816;regulation of membrane potential#GO:0042391;cellular response to stimulus#GO:0051716;chemical synaptic transmission#GO:0007268;metal ion transport#GO:0030001;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;trans-synaptic signaling#GO:0099537;response to nitrogen compound#GO:1901698;localization#GO:0051179;cell communication#GO:0007154;monoatomic cation transport#GO:0006812;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;cellular response to nitrogen compound#GO:1901699;synaptic transmission, cholinergic#GO:0007271;transport#GO:0006810;establishment of localization#GO:0051234 plasma membrane#GO:0005886;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane#GO:0016020;membrane protein complex#GO:0098796;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;signaling receptor complex#GO:0043235;cation channel complex#GO:0034703 ligand-gated ion channel#PC00141 HUMAN|HGNC=32933|UniProtKB=Q6IPU0 Q6IPU0 CENPP PTHR28577:SF1 CENTROMERE PROTEIN P CENTROMERE PROTEIN P intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=28196|UniProtKB=Q9BSE2 Q9BSE2 TMEM79 PTHR31004:SF1 TRANSMEMBRANE PROTEIN 79 TRANSMEMBRANE PROTEIN 79 cellular process#GO:0009987;export from cell#GO:0140352;vesicle-mediated transport#GO:0016192;transport#GO:0006810;regulated exocytosis#GO:0045055;secretion by cell#GO:0032940;exocytosis#GO:0006887;localization#GO:0051179;establishment of localization#GO:0051234;secretion#GO:0046903 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;lysosome#GO:0005764;lytic vacuole membrane#GO:0098852;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;vacuolar membrane#GO:0005774;lytic vacuole#GO:0000323;Golgi apparatus#GO:0005794;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;vacuole#GO:0005773;endomembrane system#GO:0012505;trans-Golgi network membrane#GO:0032588;lysosomal membrane#GO:0005765;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020 HUMAN|HGNC=9495|UniProtKB=P24158 P24158 PRTN3 PTHR24257:SF15 CHYMOTRYPSIN-LIKE ELASTASE FAMILY MEMBER MYELOBLASTIN catalytic activity#GO:0003824;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171 cellular process#GO:0009987;primary metabolic process#GO:0044238;proteolysis#GO:0006508;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease#PC00190;serine protease#PC00203;protein modifying enzyme#PC00260 HUMAN|HGNC=7547|UniProtKB=P10243 P10243 MYBL1 PTHR45614:SF9 MYB PROTEIN-RELATED MYB-RELATED PROTEIN A sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;mitotic cell cycle#GO:0000278;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;cell cycle#GO:0007049;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 homeodomain transcription factor#PC00119 HUMAN|HGNC=24526|UniProtKB=Q6DD88 Q6DD88 ATL3 PTHR10751:SF32 GUANYLATE BINDING PROTEIN ATLASTIN-3 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111 cellular component organization#GO:0016043;organelle organization#GO:0006996;endoplasmic reticulum organization#GO:0007029;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;endomembrane system organization#GO:0010256 heterotrimeric G-protein#PC00117;G-protein#PC00020 HUMAN|HGNC=11545|UniProtKB=Q16514 Q16514 TAF12 PTHR12264:SF21 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12 structural molecule activity#GO:0005198;protein complex scaffold activity#GO:0140378 nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;protein-containing complex assembly#GO:0065003;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;DNA-templated transcription#GO:0006351;RNA polymerase II preinitiation complex assembly#GO:0051123;RNA biosynthetic process#GO:0032774;DNA-templated transcription initiation#GO:0006352;transcription by RNA polymerase II#GO:0006366;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-DNA complex organization#GO:0071824;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;transcription initiation at RNA polymerase II promoter#GO:0006367;cellular component biogenesis#GO:0044085;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;protein-DNA complex assembly#GO:0065004;gene expression#GO:0010467;cellular component assembly#GO:0022607 organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;RNA polymerase II, holoenzyme#GO:0016591;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;transcription factor TFIID complex#GO:0005669;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;transcription regulator complex#GO:0005667 RNA metabolism protein#PC00031;general transcription factor#PC00259 General transcription regulation#P00023>TBP-associated factors#P00658;Transcription regulation by bZIP transcription factor#P00055>TBP-associated factors#P01385 HUMAN|HGNC=16925|UniProtKB=Q96P48 Q96P48 ARAP1 PTHR45899:SF3 RHO GTPASE ACTIVATING PROTEIN AT 15B, ISOFORM C ARF-GAP WITH RHO-GAP DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 1 molecular function regulator activity#GO:0098772;phosphatidylinositol phosphate binding#GO:1901981;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;phospholipid binding#GO:0005543;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;lipid binding#GO:0008289;enzyme regulator activity#GO:0030234;anion binding#GO:0043168;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167 regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;regulation of actin cytoskeleton organization#GO:0032956;biological regulation#GO:0065007;regulation of actin filament-based process#GO:0032970;regulation of cell projection organization#GO:0031344 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;trans-Golgi network#GO:0005802;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cell periphery#GO:0071944;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794 GTPase-activating protein#PC00257 HUMAN|HGNC=3678|UniProtKB=Q9NSA1 Q9NSA1 FGF21 PTHR11486:SF81 FIBROBLAST GROWTH FACTOR FIBROBLAST GROWTH FACTOR 21 binding#GO:0005488;signaling receptor binding#GO:0005102;protein binding#GO:0005515;molecular function activator activity#GO:0140677;growth factor activity#GO:0008083;signaling receptor regulator activity#GO:0030545;growth factor receptor binding#GO:0070851;receptor ligand activity#GO:0048018;fibroblast growth factor receptor binding#GO:0005104;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772 cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;response to growth factor#GO:0070848;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;system development#GO:0048731;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;regulation of cell population proliferation#GO:0042127;regulation of cell motility#GO:2000145;cell communication#GO:0007154;positive regulation of cellular process#GO:0048522;regulation of locomotion#GO:0040012;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;multicellular organismal process#GO:0032501;fibroblast growth factor receptor signaling pathway#GO:0008543;positive regulation of response to stimulus#GO:0048584;regulation of response to stimulus#GO:0048583;regulation of cell migration#GO:0030334;positive regulation of intracellular signal transduction#GO:1902533;developmental process#GO:0032502;response to fibroblast growth factor#GO:0071774;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;positive regulation of MAPK cascade#GO:0043410;regulation of biological process#GO:0050789;positive regulation of cell population proliferation#GO:0008284;response to endogenous stimulus#GO:0009719;signaling#GO:0023052;response to stimulus#GO:0050896;cell differentiation#GO:0030154;cellular response to endogenous stimulus#GO:0071495;regulation of signaling#GO:0023051;animal gross anatomical part developmental process#GO:0160108;regulation of intracellular signal transduction#GO:1902531;cellular response to growth factor stimulus#GO:0071363;positive regulation of signaling#GO:0023056;cellular response to fibroblast growth factor stimulus#GO:0044344;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;nervous system development#GO:0007399;cell surface receptor signaling pathway#GO:0007166;regulation of MAPK cascade#GO:0043408;multicellular organism development#GO:0007275 extracellular region#GO:0005576;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207;growth factor#PC00112 HUMAN|HGNC=5300|UniProtKB=P47898 P47898 HTR5A PTHR24247:SF108 5-HYDROXYTRYPTAMINE RECEPTOR 5-HYDROXYTRYPTAMINE RECEPTOR 5A heterocyclic compound binding#GO:1901363;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;neurotransmitter receptor activity#GO:0030594;G protein-coupled amine receptor activity#GO:0008227;molecular transducer activity#GO:0060089;cation binding#GO:0043169;serotonin binding#GO:0051378;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888 adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway#GO:0007193;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;synaptic signaling#GO:0099536;cell communication#GO:0007154;trans-synaptic signaling#GO:0099537;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268 cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;dendrite#GO:0030425;dendritic tree#GO:0097447 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GsPCR#P00720 HUMAN|HGNC=16525|UniProtKB=Q9H0N0 Q9H0N0 RAB6C PTHR24073:SF1089 DRAB5-RELATED RAS-RELATED PROTEIN RAB-6A-RELATED hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides#GO:0016817 protein transport#GO:0015031;cellular localization#GO:0051641;localization#GO:0051179;localization within membrane#GO:0051668;cytosolic transport#GO:0016482;protein localization to organelle#GO:0033365;intra-Golgi vesicle-mediated transport#GO:0006891;protein localization to membrane#GO:0072657;intracellular protein localization#GO:0008104;endosomal transport#GO:0016197;establishment of localization#GO:0051234;transport#GO:0006810;intracellular protein transport#GO:0006886;Golgi vesicle transport#GO:0048193;intracellular transport#GO:0046907;protein localization to Golgi apparatus#GO:0034067;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;establishment of protein localization#GO:0045184;retrograde transport, endosome to Golgi#GO:0042147;macromolecule localization#GO:0033036 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 G-protein#PC00020;small GTPase#PC00208 HUMAN|HGNC=21239|UniProtKB=Q9P0B6 Q9P0B6 CCDC167 PTHR31759:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 167 COILED-COIL DOMAIN-CONTAINING PROTEIN 167 HUMAN|HGNC=21|UniProtKB=Q6ZMQ8 Q6ZMQ8 AATK PTHR24417:SF0 SERINE/THREONINE-PROTEIN KINASE LMTK1 SERINE_THREONINE-PROTEIN KINASE LMTK1 protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein tyrosine kinase activity#GO:0004713;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096 central nervous system development#GO:0007417;programmed cell death#GO:0012501;apoptotic process#GO:0006915;cell death#GO:0008219;neuron apoptotic process#GO:0051402;anatomical structure development#GO:0048856;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;brain development#GO:0007420;multicellular organismal process#GO:0032501;head development#GO:0060322;nervous system development#GO:0007399;cellular process#GO:0009987;multicellular organism development#GO:0007275;animal organ development#GO:0048513;developmental process#GO:0032502 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=32069|UniProtKB=Q5T700 Q5T700 LDLRAD1 PTHR22722:SF20 LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED LOW-DENSITY LIPOPROTEIN RECEPTOR CLASS A DOMAIN-CONTAINING PROTEIN 1 HUMAN|HGNC=24331|UniProtKB=Q5VYJ5 Q5VYJ5 MALRD1 PTHR23282:SF140 APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR. MAM AND LDL-RECEPTOR CLASS A DOMAIN-CONTAINING PROTEIN 1 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 HUMAN|HGNC=11152|UniProtKB=P09661 P09661 SNRPA1 PTHR10552:SF11 U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A' nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723;snRNA binding#GO:0017069 macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 intracellular organelle#GO:0043229;U2 snRNP#GO:0005686;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513;spliceosomal snRNP complex#GO:0097525;nucleus#GO:0005634;small nuclear ribonucleoprotein complex#GO:0030532;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226 RNA splicing factor#PC00148 HUMAN|HGNC=5528|UniProtKB=P01861 P01861 IGHG4 PTHR23411:SF39 TAPASIN IMMUNOGLOBULIN HEAVY CONSTANT GAMMA 1-RELATED antigen binding#GO:0003823;signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;defense response to bacterium#GO:0042742;immune system process#GO:0002376;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;antibacterial humoral response#GO:0019731;immune effector process#GO:0002252;antimicrobial humoral response#GO:0019730;humoral immune response#GO:0006959;defense response to other organism#GO:0098542;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;defense response to symbiont#GO:0140546;positive regulation of immune system process#GO:0002684;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;regulation of immune response#GO:0050776;response to bacterium#GO:0009617;response to external biotic stimulus#GO:0043207;regulation of immune system process#GO:0002682;defense response#GO:0006952;response to external stimulus#GO:0009605;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;adaptive immune response#GO:0002250;response to other organism#GO:0051707;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;immune response#GO:0006955;complement activation#GO:0006956 extracellular region#GO:0005576;extracellular protein-containing complex#GO:0140392;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=31350|UniProtKB=Q9NWM3 Q9NWM3 CUEDC1 PTHR13467:SF3 CUE DOMAIN CONTAINING PROTEIN 1 CUE DOMAIN-CONTAINING PROTEIN 1 HUMAN|HGNC=11254|UniProtKB=O43791 O43791 SPOP PTHR24413:SF97 SPECKLE-TYPE POZ PROTEIN SPECKLE-TYPE POZ PROTEIN enzyme binding#GO:0019899;ubiquitin-like protein ligase binding#GO:0044389;binding#GO:0005488;ubiquitin protein ligase binding#GO:0031625;protein binding#GO:0005515 regulation of proteolysis#GO:0030162;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;biological regulation#GO:0065007;proteasomal protein catabolic process#GO:0010498;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein metabolic process#GO:0019538;modification-dependent protein catabolic process#GO:0019941;regulation of biological process#GO:0050789;primary metabolic process#GO:0044238;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=20932|UniProtKB=Q15054 Q15054 POLD3 PTHR17598:SF13 DNA POLYMERASE DELTA SUBUNIT 3 DNA POLYMERASE DELTA SUBUNIT 3 DNA-directed DNA polymerase activity#GO:0003887;catalytic activity, acting on DNA#GO:0140097;DNA polymerase activity#GO:0034061;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a nucleic acid#GO:0140640;nucleotidyltransferase activity#GO:0016779;catalytic activity#GO:0003824;transferase activity#GO:0016740 response to stress#GO:0006950;DNA biosynthetic process#GO:0071897;cellular process#GO:0009987;response to radiation#GO:0009314;macromolecule biosynthetic process#GO:0009059;cellular response to light stimulus#GO:0071482;nucleotide-excision repair#GO:0006289;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;DNA repair#GO:0006281;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;DNA metabolic process#GO:0006259;DNA damage response#GO:0006974;response to UV#GO:0009411;macromolecule metabolic process#GO:0043170;cellular response to abiotic stimulus#GO:0071214;response to abiotic stimulus#GO:0009628;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;DNA replication#GO:0006260;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;response to light stimulus#GO:0009416;cellular response to environmental stimulus#GO:0104004;cellular response to radiation#GO:0071478;DNA strand elongation involved in DNA replication#GO:0006271;nucleic acid biosynthetic process#GO:0141187;cellular response to stress#GO:0033554;DNA-templated DNA replication#GO:0006261 nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;transferase complex#GO:1990234;DNA polymerase complex#GO:0042575;intracellular membrane-bounded organelle#GO:0043231;protein-DNA complex#GO:0032993;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;replisome#GO:0030894;replication fork#GO:0005657;chromosome#GO:0005694;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nuclear replication fork#GO:0043596;transferase complex, transferring phosphorus-containing groups#GO:0061695 DNA metabolism protein#PC00009 HUMAN|HGNC=30829|UniProtKB=Q9BVA1 Q9BVA1 TUBB2B PTHR11588:SF330 TUBULIN TUBULIN BETA-2B CHAIN structural molecule activity#GO:0005198;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;anion binding#GO:0043168;ion binding#GO:0043167;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;ribonucleotide binding#GO:0032553;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;carbohydrate derivative binding#GO:0097367;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;guanyl nucleotide binding#GO:0019001;binding#GO:0005488;structural constituent of cytoskeleton#GO:0005200;nucleoside phosphate binding#GO:1901265 mitotic cell cycle#GO:0000278;cell differentiation#GO:0030154;cell motility#GO:0048870;cell cycle#GO:0007049;cellular component organization#GO:0016043;system development#GO:0048731;anatomical structure development#GO:0048856;microtubule cytoskeleton organization#GO:0000226;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cytoskeleton organization#GO:0007010;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;cell migration#GO:0016477;cellular process#GO:0009987;organelle organization#GO:0006996;microtubule-based process#GO:0007017;neurogenesis#GO:0022008;cellular component organization or biogenesis#GO:0071840;neuron migration#GO:0001764;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;developmental process#GO:0032502 polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;organelle#GO:0043226;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630 cytoskeletal protein#PC00085;tubulin#PC00228 Huntington disease#P00029>Microtubule#P00780;Cytoskeletal regulation by Rho GTPase#P00016>tubulin#P00526;Huntington disease#P00029>beta-Tubulin#P00790 HUMAN|HGNC=5628|UniProtKB=P01782 P01782 IGHV3-9 PTHR23266:SF400 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 3-9 antigen binding#GO:0003823;binding#GO:0005488 adaptive immune response#GO:0002250;response to stimulus#GO:0050896;immune response#GO:0006955;immunoglobulin mediated immune response#GO:0016064;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449;immune effector process#GO:0002252;immune system process#GO:0002376 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=19946|UniProtKB=Q5T5Y3 Q5T5Y3 CAMSAP1 PTHR21595:SF3 PATRONIN CALMODULIN-REGULATED SPECTRIN-ASSOCIATED PROTEIN 1 cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;microtubule binding#GO:0008017;binding#GO:0005488;protein binding#GO:0005515 regulation of microtubule cytoskeleton organization#GO:0070507;negative regulation of protein depolymerization#GO:1901880;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;regulation of protein-containing complex disassembly#GO:0043244;organelle organization#GO:0006996;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;regulation of protein depolymerization#GO:1901879;regulation of microtubule polymerization or depolymerization#GO:0031110;negative regulation of cellular process#GO:0048523;cytoplasmic microtubule organization#GO:0031122;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;negative regulation of supramolecular fiber organization#GO:1902904;regulation of cytoskeleton organization#GO:0051493;negative regulation of cellular component organization#GO:0051129;cellular component organization#GO:0016043;negative regulation of organelle organization#GO:0010639;negative regulation of biological process#GO:0048519;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of supramolecular fiber organization#GO:1902903;negative regulation of protein-containing complex disassembly#GO:0043242;microtubule cytoskeleton organization#GO:0000226;negative regulation of cytoskeleton organization#GO:0051494;supramolecular fiber organization#GO:0097435;regulation of microtubule-based process#GO:0032886 microtubule cytoskeleton#GO:0015630;microtubule end#GO:1990752;organelle#GO:0043226;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;microtubule#GO:0005874;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=25443|UniProtKB=Q9NSK7 Q9NSK7 C19orf12 PTHR31493:SF1 NAZO FAMILY MEMBER PROTEIN C19ORF12 metabolic process#GO:0008152;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;cellular homeostasis#GO:0019725;monoatomic ion homeostasis#GO:0050801;autophagy#GO:0006914;cellular process#GO:0009987;calcium ion homeostasis#GO:0055074;inorganic ion homeostasis#GO:0098771;process utilizing autophagic mechanism#GO:0061919;intracellular monoatomic ion homeostasis#GO:0006873;catabolic process#GO:0009056;mitochondrial calcium ion homeostasis#GO:0051560;homeostatic process#GO:0042592 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;mitochondrial envelope#GO:0005740;organelle envelope#GO:0031967;membrane#GO:0016020 HUMAN|HGNC=6985|UniProtKB=Q16798 Q16798 ME3 PTHR23406:SF20 MALIC ENZYME-RELATED NADP-DEPENDENT MALIC ENZYME, MITOCHONDRIAL oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 oxidoreductase#PC00176 HUMAN|HGNC=26099|UniProtKB=A1A4S6 A1A4S6 ARHGAP10 PTHR12552:SF5 OLIGOPHRENIN 1 RHO GTPASE-ACTIVATING PROTEIN 10 enzyme activator activity#GO:0008047;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695 cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;negative regulation of apoptotic process#GO:0043066;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of programmed cell death#GO:0043069;cellular process#GO:0009987;negative regulation of biological process#GO:0048519;organelle organization#GO:0006996;regulation of programmed cell death#GO:0043067;cellular component organization#GO:0016043;cellular component organization or biogenesis#GO:0071840;regulation of apoptotic process#GO:0042981;negative regulation of cellular process#GO:0048523 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 GTPase-activating protein#PC00257 Integrin signalling pathway#P00034>GRAF#P00926;PDGF signaling pathway#P00047>Rho#P01174 HUMAN|HGNC=28653|UniProtKB=Q96IK0 Q96IK0 TMEM101 PTHR31034:SF2 TRANSMEMBRANE PROTEIN 101 TRANSMEMBRANE PROTEIN 101 HUMAN|HGNC=9315|UniProtKB=P16298 P16298 PPP3CB PTHR45673:SF7 SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED SERINE_THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT BETA ISOFORM binding#GO:0005488;protein binding#GO:0005515;hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721;protein serine/threonine phosphatase activity#GO:0004722;calmodulin binding#GO:0005516;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578 biological regulation#GO:0065007;signaling#GO:0023052;intracellular signaling cassette#GO:0141124;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;calcineurin-mediated signaling#GO:0097720;calcium-mediated signaling#GO:0019722;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;protein serine/threonine phosphatase complex#GO:0008287;catalytic complex#GO:1902494 protein phosphatase#PC00195 Wnt signaling pathway#P00057>Calcineurin#P01446;T cell activation#P00053>Calcineurin#P01315;B cell activation#P00010>Calcineurin#P00386 HUMAN|HGNC=2198|UniProtKB=P08123 P08123 COL1A2 PTHR24023:SF568 COLLAGEN ALPHA COLLAGEN ALPHA-2(I) CHAIN extracellular matrix structural constituent#GO:0005201;structural molecule activity#GO:0005198 animal gross anatomical part developmental process#GO:0160108;extracellular structure organization#GO:0043062;developmental process#GO:0032502;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;skeletal system development#GO:0001501;anatomical structure development#GO:0048856;animal organ development#GO:0048513;extracellular matrix organization#GO:0030198;system development#GO:0048731;external encapsulating structure organization#GO:0045229;cellular component organization#GO:0016043;cellular process#GO:0009987;multicellular organismal process#GO:0032501;skin development#GO:0043588 extracellular region#GO:0005576;extracellular protein-containing complex#GO:0140392;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;supramolecular complex#GO:0099080;interstitial matrix#GO:0005614;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 Integrin signalling pathway#P00034>Collagen#P00922 HUMAN|HGNC=8055|UniProtKB=Q8WV74 Q8WV74 NUDT8 PTHR12992:SF11 NUDIX HYDROLASE MITOCHONDRIAL COENZYME A DIPHOSPHATASE NUDT8 hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462 nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;nucleoside phosphate catabolic process#GO:1901292;purine-containing compound metabolic process#GO:0072521;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;organophosphate catabolic process#GO:0046434;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;nucleobase-containing compound catabolic process#GO:0034655;sulfur compound metabolic process#GO:0006790;nucleobase-containing small molecule metabolic process#GO:0055086;purine-containing compound catabolic process#GO:0072523;sulfur compound catabolic process#GO:0044273;metabolic process#GO:0008152 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 hydrolase#PC00121;phosphatase#PC00181 HUMAN|HGNC=26817|UniProtKB=Q86SG4 Q86SG4 HMGN2P46 PTHR23087:SF27 NONHISTONE CHROMOSOMAL PROTEIN HMG DRESDEN PROSTATE CARCINOMA PROTEIN 2-RELATED binding#GO:0005488;chromatin binding#GO:0003682 chromatin organization#GO:0006325;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=1191|UniProtKB=Q9Y6B2 Q9Y6B2 EID1 PTHR15556:SF5 EP300-INTERACTING INHIBITOR OF DIFFERENTIATION 2-RELATED EP300-INTERACTING INHIBITOR OF DIFFERENTIATION 1 transcription regulator activity#GO:0140110;transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of metabolic process#GO:0009892;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934 nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 HUMAN|HGNC=1104|UniProtKB=Q15059 Q15059 BRD3 PTHR22880:SF246 FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS BROMODOMAIN-CONTAINING PROTEIN 3 chromatin-protein adaptor activity#GO:0140463;histone reader activity#GO:0140566;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;chromatin organization#GO:0006325;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;chromatin remodeling#GO:0006338;cellular component organization#GO:0016043;regulation of biological process#GO:0050789 intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=8738|UniProtKB=Q15113 Q15113 PCOLCE PTHR24251:SF24 OVOCHYMASE-RELATED PROCOLLAGEN C-ENDOPEPTIDASE ENHANCER 1 enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;protein-containing complex binding#GO:0044877;collagen binding#GO:0005518;binding#GO:0005488;peptidase regulator activity#GO:0061134;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047;peptidase activator activity#GO:0016504 proteolysis#GO:0006508;metabolic process#GO:0008152;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 serine protease#PC00203;protease#PC00190 HUMAN|HGNC=7033|UniProtKB=P55001 P55001 MFAP2 PTHR16485:SF3 MICROFIBRILLAR-ASSOCIATED PROTEIN 2 MICROFIBRILLAR-ASSOCIATED PROTEIN 2 animal organ development#GO:0048513;embryonic morphogenesis#GO:0048598;multicellular organism development#GO:0007275;developmental process#GO:0032502;sensory organ development#GO:0007423;embryo development#GO:0009790;multicellular organismal process#GO:0032501;sensory system development#GO:0048880;eye development#GO:0001654;system development#GO:0048731;anatomical structure development#GO:0048856;embryonic organ development#GO:0048568;animal gross anatomical part developmental process#GO:0160108;visual system development#GO:0150063;animal organ morphogenesis#GO:0009887;sensory organ morphogenesis#GO:0090596;anatomical structure morphogenesis#GO:0009653 cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;interstitial matrix#GO:0005614;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;supramolecular fiber#GO:0099512;extracellular region#GO:0005576 HUMAN|HGNC=17178|UniProtKB=P59510 P59510 ADAMTS20 PTHR13723:SF165 ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 20 metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096 primary metabolic process#GO:0044238;cellular component organization#GO:0016043;cellular process#GO:0009987;protein metabolic process#GO:0019538;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;external encapsulating structure organization#GO:0045229;extracellular structure organization#GO:0043062;metabolic process#GO:0008152;proteolysis#GO:0006508 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012 metalloprotease#PC00153 HUMAN|HGNC=4480|UniProtKB=O00155 O00155 GPR25 PTHR24228:SF9 B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR C-X-C CHEMOKINE RECEPTOR GPR25 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=12558|UniProtKB=O75385 O75385 ULK1 PTHR24348:SF19 SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED SERINE_THREONINE-PROTEIN KINASE ULK1 kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 cellular component assembly#GO:0022607;regulation of cell growth#GO:0001558;regulation of multicellular organismal process#GO:0051239;response to stress#GO:0006950;autophagy#GO:0006914;cell growth#GO:0016049;regulation of axonogenesis#GO:0050770;cell projection morphogenesis#GO:0048858;metabolic process#GO:0008152;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cellular component organization#GO:0016043;regulation of multicellular organismal development#GO:2000026;regulation of cellular component size#GO:0032535;developmental growth involved in morphogenesis#GO:0060560;regulation of cell size#GO:0008361;generation of neurons#GO:0048699;negative regulation of cell growth#GO:0030308;plasma membrane bounded cell projection organization#GO:0120036;macroautophagy#GO:0016236;axon development#GO:0061564;reticulophagy#GO:0061709;response to nutrient levels#GO:0031667;cellular developmental process#GO:0048869;autophagy of mitochondrion#GO:0000422;developmental process#GO:0032502;catabolic process#GO:0009056;regulation of developmental process#GO:0050793;negative regulation of cellular component organization#GO:0051129;response to starvation#GO:0042594;regulation of growth#GO:0040008;regulation of nervous system development#GO:0051960;system development#GO:0048731;vacuole organization#GO:0007033;organelle assembly#GO:0070925;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;axon extension#GO:0048675;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;neuron projection development#GO:0031175;cellular process#GO:0009987;autophagosome organization#GO:1905037;regulation of neuron projection development#GO:0010975;regulation of anatomical structure morphogenesis#GO:0022603;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;autophagosome assembly#GO:0000045;regulation of anatomical structure size#GO:0090066;growth#GO:0040007;neuron differentiation#GO:0030182;cell morphogenesis#GO:0000902;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;cell development#GO:0048468;regulation of autophagy#GO:0010506;negative regulation of biological process#GO:0048519;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;axonogenesis#GO:0007409;regulation of biological quality#GO:0065008;neuron projection extension#GO:1990138;process utilizing autophagic mechanism#GO:0061919;neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of cell development#GO:0060284;developmental growth#GO:0048589;mitophagy#GO:0000423;regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of catabolic process#GO:0009894;neurogenesis#GO:0022008;negative regulation of cellular process#GO:0048523;regulation of cell projection organization#GO:0031344;neuron projection morphogenesis#GO:0048812;regulation of cell differentiation#GO:0045595;regulation of cellular process#GO:0050794;developmental cell growth#GO:0048588;piecemeal microautophagy of the nucleus#GO:0034727;regulation of neurogenesis#GO:0050767;negative regulation of multicellular organismal process#GO:0051241;anatomical structure development#GO:0048856 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;phagophore assembly site#GO:0000407;autophagosome#GO:0005776;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;vacuole#GO:0005773;cellular anatomical structure#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;cytosol#GO:0005829 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=19870|UniProtKB=Q7Z5H4 Q7Z5H4 VN1R5 PTHR24062:SF174 VOMERONASAL TYPE-1 RECEPTOR VOMERONASAL TYPE-1 RECEPTOR 5 binding#GO:0005488 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=20659|UniProtKB=O60636 O60636 TSPAN2 PTHR19282:SF155 TETRASPANIN TETRASPANIN-2 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HUMAN|HGNC=28517|UniProtKB=Q8NBL3 Q8NBL3 TMEM178A PTHR32005:SF4 TRANSMEMBRANE PROTEIN 178B-RELATED TRANSMEMBRANE PROTEIN 178A regulation of multicellular organismal development#GO:2000026;regulation of cytosolic calcium ion concentration#GO:0051480;regulation of biological process#GO:0050789;intracellular monoatomic ion homeostasis#GO:0006873;negative regulation of biological process#GO:0048519;negative regulation of multicellular organismal process#GO:0051241;regulation of developmental process#GO:0050793;homeostatic process#GO:0042592;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;regulation of myeloid cell differentiation#GO:0045637;regulation of hemopoiesis#GO:1903706;regulation of cell development#GO:0060284;monoatomic ion homeostasis#GO:0050801;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;negative regulation of immune system process#GO:0002683;monoatomic cation homeostasis#GO:0055080;regulation of cell differentiation#GO:0045595;intracellular monoatomic cation homeostasis#GO:0030003;chemical homeostasis#GO:0048878;negative regulation of cellular process#GO:0048523;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229 HUMAN|HGNC=18798|UniProtKB=Q8WWI5 Q8WWI5 SLC44A1 PTHR12385:SF56 CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44) CHOLINE TRANSPORTER-LIKE PROTEIN 1 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;cellular process#GO:0009987;transport#GO:0006810;nitrogen compound transport#GO:0071705 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227;secondary carrier transporter#PC00258 HUMAN|HGNC=4174|UniProtKB=Q92908 Q92908 GATA6 PTHR10071:SF23 TRANSCRIPTION FACTOR GATA FAMILY MEMBER TRANSCRIPTION FACTOR GATA-6 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 positive regulation of transcription by RNA polymerase II#GO:0045944;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;positive regulation of macromolecule metabolic process#GO:0010604;negative regulation of macromolecule biosynthetic process#GO:0010558;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;negative regulation of DNA-templated transcription#GO:0045892;cell fate commitment#GO:0045165;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;animal gross anatomical part developmental process#GO:0160108;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;epithelium development#GO:0060429;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;tissue development#GO:0009888;epithelial cell differentiation#GO:0030855;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218 HUMAN|HGNC=27312|UniProtKB=Q8IZD0 Q8IZD0 SAMD14 PTHR16154:SF28 NEURABIN STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 14 cytoskeletal protein binding#GO:0008092;molecular adaptor activity#GO:0060090;actin filament binding#GO:0051015;actin binding#GO:0003779;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;protein-containing complex binding#GO:0044877;protein-membrane adaptor activity#GO:0043495;protein binding#GO:0005515 generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;neuron development#GO:0048666;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;cell development#GO:0048468;signaling#GO:0023052;cell projection organization#GO:0030030;response to stimulus#GO:0050896;cell differentiation#GO:0030154;neuron differentiation#GO:0030182;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cellular process#GO:0009987;signal transduction#GO:0007165;organelle organization#GO:0006996;neuron projection development#GO:0031175;nervous system development#GO:0007399;intracellular signaling cassette#GO:0141124;cytoskeleton organization#GO:0007010;actin filament-based process#GO:0030029;intracellular signal transduction#GO:0035556;system development#GO:0048731;supramolecular fiber organization#GO:0097435;anatomical structure development#GO:0048856;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;developmental process#GO:0032502;calcium-mediated signaling#GO:0019722;neurogenesis#GO:0022008;actin filament organization#GO:0007015;cellular developmental process#GO:0048869;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;multicellular organismal process#GO:0032501 organelle#GO:0043226;asymmetric synapse#GO:0032279;cellular anatomical structure#GO:0110165;synapse#GO:0045202;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;actin cytoskeleton#GO:0015629;postsynapse#GO:0098794;cortical cytoskeleton#GO:0030863;cell cortex#GO:0005938;actin-based cell projection#GO:0098858;intracellular anatomical structure#GO:0005622;filopodium#GO:0030175;dendrite#GO:0030425;intracellular organelle#GO:0043229;dendritic tree#GO:0097447;postsynaptic density#GO:0014069;postsynaptic specialization#GO:0099572;neuron to neuron synapse#GO:0098984;intracellular membraneless organelle#GO:0043232;somatodendritic compartment#GO:0036477;cortical actin cytoskeleton#GO:0030864;cytoplasm#GO:0005737;neuron projection#GO:0043005;cell periphery#GO:0071944;cell junction#GO:0030054;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856 HUMAN|HGNC=53426|UniProtKB=A0A0U1RR37 A0A0U1RR37 C1orf232 PTHR35663:SF3 TESTIS DEVELOPMENT-RELATED PROTEIN-RELATED GENE, 30191-RELATED HUMAN|HGNC=11579|UniProtKB=O75347 O75347 TBCA PTHR21500:SF3 TUBULIN-SPECIFIC CHAPERONE A TUBULIN-SPECIFIC CHAPERONE A cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;binding#GO:0005488;protein binding#GO:0005515 protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043 intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;microtubule cytoskeleton#GO:0015630;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 chaperonin#PC00073 HUMAN|HGNC=26074|UniProtKB=Q9NWS1 Q9NWS1 PARPBP PTHR32121:SF0 PCNA-INTERACTING PARTNER PCNA-INTERACTING PARTNER regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of response to stimulus#GO:0048585;biological regulation#GO:0065007;negative regulation of DNA metabolic process#GO:0051053;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of cellular process#GO:0048523;regulation of response to stress#GO:0080134;negative regulation of double-strand break repair via homologous recombination#GO:2000042;regulation of response to stimulus#GO:0048583;regulation of DNA repair#GO:0006282;regulation of macromolecule metabolic process#GO:0060255;regulation of double-strand break repair via homologous recombination#GO:0010569;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;negative regulation of DNA recombination#GO:0045910;regulation of biological process#GO:0050789;regulation of DNA metabolic process#GO:0051052;regulation of double-strand break repair#GO:2000779;regulation of cellular response to stress#GO:0080135;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of DNA recombination#GO:0000018 chromatin#GO:0000785;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 HUMAN|HGNC=28288|UniProtKB=Q96A25 Q96A25 TMEM106A PTHR28556:SF3 TRANSMEMBRANE PROTEIN 106B TRANSMEMBRANE PROTEIN 106A myeloid leukocyte activation#GO:0002274;multicellular organismal process#GO:0032501;macrophage activation#GO:0042116;cellular process#GO:0009987;cell activation#GO:0001775;immune system process#GO:0002376;leukocyte activation#GO:0045321 cytoplasm#GO:0005737;vacuole#GO:0005773;lysosomal membrane#GO:0005765;membrane#GO:0016020;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;vacuolar membrane#GO:0005774;lytic vacuole#GO:0000323;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;lysosome#GO:0005764;lytic vacuole membrane#GO:0098852;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HUMAN|HGNC=3312|UniProtKB=Q15717 Q15717 ELAVL1 PTHR10352:SF13 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G ELAV-LIKE PROTEIN 1 regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;negative regulation of metabolic process#GO:0009892;regulation of mRNA stability#GO:0043488;regulation of biological quality#GO:0065008;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;RNA stabilization#GO:0043489;positive regulation of biological process#GO:0048518;mRNA stabilization#GO:0048255;positive regulation of macromolecule metabolic process#GO:0010604;negative regulation of RNA metabolic process#GO:0051253;regulation of mRNA metabolic process#GO:1903311;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA stability#GO:0043487;negative regulation of catabolic process#GO:0009895;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of RNA catabolic process#GO:1902369;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;positive regulation of gene expression#GO:0010628;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226 translation factor#PC00223;translation initiation factor#PC00224;translational protein#PC00263 CCKR signaling map#P06959>HuR#G07273;CCKR signaling map#P06959>HuR#P07211;CCKR signaling map#P06959>HuR#G06980 HUMAN|HGNC=14073|UniProtKB=Q13733 Q13733 ATP1A4 PTHR43294:SF3 SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA-4 ATPase-coupled transmembrane transporter activity#GO:0042626;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATP-dependent activity#GO:0140657;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;P-type ion transporter activity#GO:0015662;active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081 monoatomic ion homeostasis#GO:0050801;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;potassium ion transport#GO:0006813;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;transport#GO:0006810;intracellular monoatomic cation homeostasis#GO:0030003;potassium ion import across plasma membrane#GO:1990573;import into cell#GO:0098657;establishment of localization#GO:0051234;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;inorganic cation import across plasma membrane#GO:0098659;intracellular monoatomic ion homeostasis#GO:0006873;sodium ion transport#GO:0006814;import across plasma membrane#GO:0098739;export from cell#GO:0140352;metal ion transport#GO:0030001;homeostatic process#GO:0042592;inorganic ion import across plasma membrane#GO:0099587;inorganic ion homeostasis#GO:0098771;potassium ion homeostasis#GO:0055075;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811 plasma membrane#GO:0005886;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;cation-transporting ATPase complex#GO:0090533;membrane#GO:0016020;membrane protein complex#GO:0098796;ATPase dependent transmembrane transport complex#GO:0098533;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495 transporter#PC00227;primary active transporter#PC00068 HUMAN|HGNC=28221|UniProtKB=Q96S82 Q96S82 UBL7 PTHR10677:SF25 UBIQUILIN UBIQUITIN-LIKE PROTEIN 7 polyubiquitin modification-dependent protein binding#GO:0031593;modification-dependent protein binding#GO:0140030;binding#GO:0005488;protein binding#GO:0005515 protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238;catabolic process#GO:0009056 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=28412|UniProtKB=Q9BQ15 Q9BQ15 NABP2 PTHR13356:SF3 OB FOLD NUCLEIC ACID BINDING PROTEIN-RELATED SOSS COMPLEX SUBUNIT B1 nucleic acid binding#GO:0003676;binding#GO:0005488;DNA binding#GO:0003677 double-strand break repair#GO:0006302;negative regulation of cell cycle G2/M phase transition#GO:1902750;negative regulation of cell cycle#GO:0045786;DNA recombination#GO:0006310;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;regulation of cell cycle process#GO:0010564;cell cycle checkpoint signaling#GO:0000075;negative regulation of mitotic cell cycle phase transition#GO:1901991;negative regulation of G2/M transition of mitotic cell cycle#GO:0010972;signal transduction#GO:0007165;cellular process#GO:0009987;response to stress#GO:0006950;negative regulation of mitotic cell cycle#GO:0045930;regulation of mitotic cell cycle phase transition#GO:1901990;cellular response to stress#GO:0033554;signaling#GO:0023052;regulation of cell cycle#GO:0051726;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;response to ionizing radiation#GO:0010212;double-strand break repair via homologous recombination#GO:0000724;cell cycle process#GO:0022402;negative regulation of biological process#GO:0048519;negative regulation of cell cycle phase transition#GO:1901988;response to abiotic stimulus#GO:0009628;mitotic cell cycle process#GO:1903047;macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;negative regulation of cell cycle process#GO:0010948;DNA repair#GO:0006281;negative regulation of cellular process#GO:0048523;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;mitotic G2/M transition checkpoint#GO:0044818;response to radiation#GO:0009314;regulation of mitotic cell cycle#GO:0007346;regulation of cell cycle G2/M phase transition#GO:1902749;intracellular signal transduction#GO:0035556;regulation of G2/M transition of mitotic cell cycle#GO:0010389;cell communication#GO:0007154;recombinational repair#GO:0000725;mitotic cell cycle#GO:0000278;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;regulation of cell cycle phase transition#GO:1901987;cell cycle#GO:0007049;mitotic cell cycle checkpoint signaling#GO:0007093;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229 damaged DNA-binding protein#PC00086;DNA metabolism protein#PC00009 HUMAN|HGNC=25294|UniProtKB=Q9H0D2 Q9H0D2 ZNF541 PTHR16089:SF23 REST COREPRESSOR COREST PROTEIN-RELATED ZINC FINGER PROTEIN 541 transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714;transcription regulator activity#GO:0140110 negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355 intracellular organelle lumen#GO:0070013;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nuclear protein-containing complex#GO:0140513;transcription regulator complex#GO:0005667;membrane-enclosed lumen#GO:0031974;histone deacetylase complex#GO:0000118;nucleus#GO:0005634;protein-containing complex#GO:0032991 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=10018|UniProtKB=Q06587 Q06587 RING1 PTHR46076:SF2 E3 UBIQUITIN-PROTEIN LIGASE RING1 / RING 2 FAMILY MEMBER E3 UBIQUITIN-PROTEIN LIGASE RING1 aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;chromatin binding#GO:0003682;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;binding#GO:0005488 negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255 ubiquitin ligase complex#GO:0000151;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;transferase complex#GO:1990234;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;PcG protein complex#GO:0031519;nucleus#GO:0005634 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=4107|UniProtKB=O75459 O75459 PAGE1 PTHR14047:SF3 P ANTIGEN FAMILY MEMBER 5-RELATED P ANTIGEN FAMILY MEMBER 1 HUMAN|HGNC=6286|UniProtKB=Q9Y691 Q9Y691 KCNMB2 PTHR10258:SF5 CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA-2 channel regulator activity#GO:0016247;molecular function regulator activity#GO:0098772;potassium channel regulator activity#GO:0015459;transporter regulator activity#GO:0141108;ion channel regulator activity#GO:0099106 nervous system process#GO:0050877;localization#GO:0051179;cell communication#GO:0007154;response to calcium ion#GO:0051592;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;detection of chemical stimulus#GO:0009593;action potential#GO:0001508;response to stimulus#GO:0050896;metal ion transport#GO:0030001;transport#GO:0006810;response to metal ion#GO:0010038;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;transmission of nerve impulse#GO:0019226;system process#GO:0003008;detection of stimulus#GO:0051606;cellular process#GO:0009987;multicellular organismal process#GO:0032501;response to chemical#GO:0042221;potassium ion transport#GO:0006813;biological regulation#GO:0065007 voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 voltage-gated ion channel#PC00241;ion channel#PC00133 HUMAN|HGNC=33241|UniProtKB=P0CG31 P0CG31 ZNF286B PTHR24377:SF217 IP01015P-RELATED ZINC FINGER PROTEIN 286A-RELATED RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=15352|UniProtKB=Q8NGD5 Q8NGD5 OR4K14 PTHR48002:SF115 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 4K14 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=26953|UniProtKB=Q2LD37 Q2LD37 BLTP1 PTHR31640:SF1 TRANSMEMBRANE PROTEIN KIAA1109 BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 1 synaptic vesicle cycle#GO:0099504;transport#GO:0006810;import into cell#GO:0098657;vesicle-mediated transport in synapse#GO:0099003;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;synaptic vesicle endocytosis#GO:0048488;synaptic vesicle recycling#GO:0036465;endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192 HUMAN|HGNC=4714|UniProtKB=P07305 P07305 H1-0 PTHR11467:SF182 HISTONE H1 HISTONE H1.0 binding#GO:0005488;nucleic acid binding#GO:0003676;chromatin binding#GO:0003682;DNA binding#GO:0003677;protein-containing complex binding#GO:0044877;double-stranded DNA binding#GO:0003690;nucleosome binding#GO:0031491;chromatin DNA binding#GO:0031490 negative regulation of metabolic process#GO:0009892;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of DNA metabolic process#GO:0051052;negative regulation of biological process#GO:0048519;negative regulation of DNA recombination#GO:0045910;cellular component organization#GO:0016043;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;chromosome condensation#GO:0030261;regulation of DNA recombination#GO:0000018;biological regulation#GO:0065007;negative regulation of DNA metabolic process#GO:0051053;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;organelle organization#GO:0006996;regulation of metabolic process#GO:0019222;chromosome organization#GO:0051276;cellular component organization or biogenesis#GO:0071840;negative regulation of cellular process#GO:0048523 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=21359|UniProtKB=Q8TB92 Q8TB92 HMGCLL1 PTHR42738:SF5 HYDROXYMETHYLGLUTARYL-COA LYASE 3-HYDROXY-3-METHYLGLUTARYL-COA LYASE, CYTOPLASMIC carbon-carbon lyase activity#GO:0016830;catalytic activity#GO:0003824;lyase activity#GO:0016829 carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;proteinogenic amino acid metabolic process#GO:0170039;lipid biosynthetic process#GO:0008610;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;small molecule catabolic process#GO:0044282;amino acid metabolic process#GO:0006520;biosynthetic process#GO:0009058;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytosol#GO:0005829 lyase#PC00144 HUMAN|HGNC=14514|UniProtKB=Q9BQC6 Q9BQC6 MRPL57 PTHR14520:SF4 MITOCHONDRIAL RIBOSOMAL PROTEIN 63 LARGE RIBOSOMAL SUBUNIT PROTEIN ML63 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;membraneless organelle#GO:0043228;mitochondrion#GO:0005739;ribosome#GO:0005840;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;mitochondrial ribosome#GO:0005761;organellar ribosome#GO:0000313;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202;translational protein#PC00263 HUMAN|HGNC=1662|UniProtKB=P28906 P28906 CD34 PTHR16677:SF1 HEMATOPOIETIC PROGENITOR CELL ANTIGEN CD34 HEMATOPOIETIC PROGENITOR CELL ANTIGEN CD34 cell-substrate adhesion#GO:0031589;cell-cell adhesion#GO:0098609;cell-matrix adhesion#GO:0007160;cell adhesion#GO:0007155;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cell adhesion molecule#PC00069 HUMAN|HGNC=37101|UniProtKB=A8MPP1 A8MPP1 DDX11L8 PTHR11472:SF41 DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER ATP-DEPENDENT DNA HELICASE DDX11-RELATED catalytic activity, acting on DNA#GO:0140097;helicase activity#GO:0004386;DNA helicase activity#GO:0003678;isomerase activity#GO:0016853;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543;ATP-dependent activity, acting on DNA#GO:0008094;ATP-dependent activity#GO:0140657 chromosome organization#GO:0051276;sister chromatid cohesion#GO:0007062;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cell cycle process#GO:0022402;cellular component organization#GO:0016043;organelle organization#GO:0006996;cell cycle#GO:0007049 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA metabolism protein#PC00009;DNA helicase#PC00011 HUMAN|HGNC=7720|UniProtKB=P20929 P20929 NEB PTHR46218:SF5 LASP NEBULIN binding#GO:0005488;actin binding#GO:0003779;actin filament binding#GO:0051015;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877 cellular anatomical structure#GO:0110165;cell junction#GO:0030054;anchoring junction#GO:0070161;focal adhesion#GO:0005925;cell-substrate junction#GO:0030055 HUMAN|HGNC=20091|UniProtKB=Q96M32 Q96M32 AK7 PTHR23359:SF105 NUCLEOTIDE KINASE ADENYLATE KINASE 7 phosphotransferase activity, phosphate group as acceptor#GO:0016776;nucleoside diphosphate kinase activity#GO:0004550;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;nucleobase-containing compound kinase activity#GO:0019205;catalytic activity#GO:0003824 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 nucleotide kinase#PC00172;kinase#PC00137 HUMAN|HGNC=12333|UniProtKB=P48995 P48995 TRPC1 PTHR10117:SF56 TRANSIENT RECEPTOR POTENTIAL CHANNEL SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 1 transporter activity#GO:0005215;alcohol binding#GO:0043178;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;binding#GO:0005488;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261;anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167;channel activity#GO:0015267 intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;transport#GO:0006810;chemical homeostasis#GO:0048878;calcium ion transport#GO:0006816;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;establishment of localization#GO:0051234;cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;regulation of cytosolic calcium ion concentration#GO:0051480;calcium ion transmembrane transport#GO:0070588;intracellular monoatomic ion homeostasis#GO:0006873;homeostatic process#GO:0042592;metal ion transport#GO:0030001 plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;cell periphery#GO:0071944;membrane#GO:0016020;membrane protein complex#GO:0098796;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cation channel complex#GO:0034703 ion channel#PC00133 Alzheimer disease-presenilin pathway#P00004>Capacitative calcium channels#P00124 HUMAN|HGNC=9792|UniProtKB=P51151 P51151 RAB9A PTHR47981:SF9 RAB FAMILY RAS-RELATED PROTEIN RAB-9A hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;molecular function regulator activity#GO:0098772 vesicle fusion#GO:0006906;cytosolic transport#GO:0016482;endocytosis#GO:0006897;cellular component organization#GO:0016043;vacuole organization#GO:0007033;localization#GO:0051179;cellular localization#GO:0051641;organelle assembly#GO:0070925;membrane organization#GO:0061024;organelle membrane fusion#GO:0090174;cellular component assembly#GO:0022607;organelle fusion#GO:0048284;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;lysosome organization#GO:0007040;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;retrograde transport, endosome to Golgi#GO:0042147;membrane fusion#GO:0061025;endosomal transport#GO:0016197;receptor-mediated endocytosis#GO:0006898;vesicle organization#GO:0016050;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;import into cell#GO:0098657;transport#GO:0006810;lytic vacuole organization#GO:0080171;phagolysosome assembly#GO:0001845;phagocytosis#GO:0006909;intracellular transport#GO:0046907 endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endocytic vesicle#GO:0030139;lysosome#GO:0005764;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;lytic vacuole#GO:0000323;cytoplasm#GO:0005737;vacuole#GO:0005773;phagocytic vesicle#GO:0045335;endomembrane system#GO:0012505;late endosome#GO:0005770 small GTPase#PC00208 HUMAN|HGNC=17305|UniProtKB=Q9Y6J9 Q9Y6J9 TAF6L PTHR10221:SF22 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6 TAF6-LIKE RNA POLYMERASE II P300_CBP-ASSOCIATED FACTOR-ASSOCIATED FACTOR 65 KDA SUBUNIT 6L structural molecule activity#GO:0005198;protein complex scaffold activity#GO:0140378 macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;transcription by RNA polymerase II#GO:0006366;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;macromolecule biosynthetic process#GO:0009059;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;RNA biosynthetic process#GO:0032774;RNA polymerase II preinitiation complex assembly#GO:0051123;DNA-templated transcription#GO:0006351;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular component organization or biogenesis#GO:0071840;protein-DNA complex organization#GO:0071824;protein-containing complex organization#GO:0043933;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;cellular component assembly#GO:0022607;gene expression#GO:0010467;protein-DNA complex assembly#GO:0065004;cellular component biogenesis#GO:0044085;transcription initiation at RNA polymerase II promoter#GO:0006367;cellular process#GO:0009987;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;DNA-templated transcription initiation#GO:0006352;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;regulation of biological process#GO:0050789 transferase complex#GO:1990234;membraneless organelle#GO:0043228;transcription regulator complex#GO:0005667;intracellular protein-containing complex#GO:0140535;membrane-enclosed lumen#GO:0031974;RNA polymerase II transcription regulator complex#GO:0090575;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;peptidase complex#GO:1905368;catalytic complex#GO:1902494;SAGA-type complex#GO:0070461;RNA polymerase II, holoenzyme#GO:0016591;membrane-bounded organelle#GO:0043227;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;chromosome#GO:0005694;nuclear DNA-directed RNA polymerase complex#GO:0055029;intracellular membrane-bounded organelle#GO:0043231;nuclear protein-containing complex#GO:0140513;histone acetyltransferase complex#GO:0000123;SAGA complex#GO:0000124;chromatin#GO:0000785;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;transcription factor TFIID complex#GO:0005669;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle#GO:0043229;protein acetyltransferase complex#GO:0031248;acetyltransferase complex#GO:1902493;organelle lumen#GO:0043233;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165 general transcription factor#PC00259 HUMAN|HGNC=37142|UniProtKB=E7ETH6 E7ETH6 ZNF587B PTHR24381:SF304 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 587B sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=19159|UniProtKB=Q96GR4 Q96GR4 ZDHHC12 PTHR22883:SF514 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE ZDHHC12 catalytic activity, acting on a protein#GO:0140096;palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746 establishment of protein localization to membrane#GO:0090150;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein targeting#GO:0006605;protein targeting to membrane#GO:0006612;localization within membrane#GO:0051668;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 protein modifying enzyme#PC00260 HUMAN|HGNC=26212|UniProtKB=P61009 P61009 SPCS3 PTHR12804:SF0 MICROSOMAL SIGNAL PEPTIDASE 23 KD SUBUNIT SPC22/23 SIGNAL PEPTIDASE COMPLEX SUBUNIT 3 gene expression#GO:0010467;protein maturation#GO:0051604;establishment of protein localization to endoplasmic reticulum#GO:0072599;biosynthetic process#GO:0009058;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;establishment of protein localization#GO:0045184;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;macromolecule metabolic process#GO:0043170;protein targeting to ER#GO:0045047;metabolic process#GO:0008152;protein targeting#GO:0006605;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;localization#GO:0051179 endoplasmic reticulum protein-containing complex#GO:0140534;organelle membrane#GO:0031090;endopeptidase complex#GO:1905369;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;peptidase complex#GO:1905368;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;membrane#GO:0016020;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane protein complex#GO:0098796 protease#PC00190 Vasopressin synthesis#P04395>Signal Peptidase#P04589 HUMAN|HGNC=21449|UniProtKB=Q86UX2 Q86UX2 ITIH5 PTHR10338:SF62 INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H5 protein-binding activity modulator#PC00095;protease inhibitor#PC00191 HUMAN|HGNC=3297|UniProtKB=P78344 P78344 EIF4G2 PTHR23253:SF9 EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2 binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;translation factor activity#GO:0180051;RNA binding#GO:0003723;translation initiation factor activity#GO:0003743 biosynthetic process#GO:0009058;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;translation#GO:0006412;translational initiation#GO:0006413;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 translation initiation factor#PC00224 HUMAN|HGNC=8056|UniProtKB=Q9BW91 Q9BW91 NUDT9 PTHR13030:SF8 NUDIX HYDROLASE ADP-RIBOSE PYROPHOSPHATASE hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HUMAN|HGNC=14558|UniProtKB=Q9BXN2 Q9BXN2 CLEC7A PTHR47218:SF1 C-TYPE LECTIN DOMAIN FAMILY 7 MEMBER A C-TYPE LECTIN DOMAIN FAMILY 7 MEMBER A binding#GO:0005488;polysaccharide binding#GO:0030247;signaling receptor activity#GO:0038023;pattern recognition receptor activity#GO:0038187;carbohydrate binding#GO:0030246;molecular transducer activity#GO:0060089 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cytokine production#GO:0001817;regulation of canonical NF-kappaB signal transduction#GO:0043122;positive regulation of cellular process#GO:0048522;immune response#GO:0006955;positive regulation of immune effector process#GO:0002699;response to other organism#GO:0051707;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;phagocytosis#GO:0006909;regulation of response to stimulus#GO:0048583;transport#GO:0006810;regulation of biosynthetic process#GO:0009889;establishment of localization#GO:0051234;innate immune response#GO:0045087;regulation of gene expression#GO:0010468;defense response#GO:0006952;response to external stimulus#GO:0009605;positive regulation of gene expression#GO:0010628;positive regulation of cytokine production#GO:0001819;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of macromolecule metabolic process#GO:0060255;regulation of cell communication#GO:0010646;response to external biotic stimulus#GO:0043207;cell recognition#GO:0008037;regulation of immune effector process#GO:0002697;localization#GO:0051179;positive regulation of biosynthetic process#GO:0009891;positive regulation of immune system process#GO:0002684;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;cellular process#GO:0009987;defense response to symbiont#GO:0140546;positive regulation of biological process#GO:0048518;defense response to other organism#GO:0098542;positive regulation of macromolecule metabolic process#GO:0010604;regulation of multicellular organismal process#GO:0051239;import into cell#GO:0098657;positive regulation of multicellular organismal process#GO:0051240;regulation of biological process#GO:0050789;endocytosis#GO:0006897;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;regulation of intracellular signal transduction#GO:1902531;immune system process#GO:0002376;regulation of cytokine production involved in immune response#GO:0002718;regulation of signaling#GO:0023051;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893 cell surface#GO:0009986;cellular anatomical structure#GO:0110165 HUMAN|HGNC=30824|UniProtKB=Q6UWB4 Q6UWB4 PRSS55 PTHR24253:SF90 TRANSMEMBRANE PROTEASE SERINE SERINE PROTEASE 55 hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;serine hydrolase activity#GO:0017171;peptidase activity#GO:0008233;catalytic activity#GO:0003824;serine-type peptidase activity#GO:0008236 biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein processing#GO:0016485;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;proteolysis#GO:0006508;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 protein modifying enzyme#PC00260;protease#PC00190;serine protease#PC00203 HUMAN|HGNC=6258|UniProtKB=Q14500 Q14500 KCNJ12 PTHR11767:SF14 INWARD RECTIFIER POTASSIUM CHANNEL ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 12-RELATED monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated monoatomic ion channel activity#GO:0005244;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;ligand-gated monoatomic ion channel activity#GO:0015276;potassium channel activity#GO:0005267;monoatomic cation channel activity#GO:0005261;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803 metal ion transport#GO:0030001;inorganic ion import across plasma membrane#GO:0099587;import across plasma membrane#GO:0098739;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813;cellular process#GO:0009987;inorganic cation import across plasma membrane#GO:0098659;potassium ion import across plasma membrane#GO:1990573;import into cell#GO:0098657;establishment of localization#GO:0051234;transport#GO:0006810 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133 HUMAN|HGNC=20308|UniProtKB=Q5W0B1 Q5W0B1 OBI1 PTHR14609:SF1 RING FINGER PROTEIN 219 ORC UBIQUITIN LIGASE 1 aminoacyltransferase activity#GO:0016755;ubiquitin-protein transferase activity#GO:0004842;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740 regulation of DNA metabolic process#GO:0051052;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of DNA replication#GO:0006275 intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;chromosome#GO:0005694;chromatin#GO:0000785;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232 HUMAN|HGNC=38705|UniProtKB=P0CJ78 P0CJ78 ZNF865 PTHR24390:SF62 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 865 nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218 HUMAN|HGNC=30423|UniProtKB=Q9HB71 Q9HB71 CACYBP PTHR13164:SF3 CALICYLIN BINDING PROTEIN CALCYCLIN-BINDING PROTEIN enzyme binding#GO:0019899;ubiquitin-like protein ligase binding#GO:0044389;binding#GO:0005488;ubiquitin protein ligase binding#GO:0031625;protein binding#GO:0005515 animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502;multicellular organism development#GO:0007275;anatomical structure development#GO:0048856;animal organ development#GO:0048513;system development#GO:0048731;circulatory system development#GO:0072359;heart development#GO:0007507;multicellular organismal process#GO:0032501 SCF ubiquitin ligase complex#GO:0019005;intracellular membrane-bounded organelle#GO:0043231;cullin-RING ubiquitin ligase complex#GO:0031461;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ubiquitin ligase complex#GO:0000151;transferase complex#GO:1990234;intracellular organelle#GO:0043229;catalytic complex#GO:1902494 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=17621|UniProtKB=Q8NFP7 Q8NFP7 NUDT10 PTHR12629:SF43 DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE 3-ALPHA hydrolase activity#GO:0016787;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817 cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;nucleobase-containing compound catabolic process#GO:0034655;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;alcohol metabolic process#GO:0006066;nucleotide catabolic process#GO:0009166;nucleobase-containing small molecule metabolic process#GO:0055086;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;nucleoside phosphate metabolic process#GO:0006753;small molecule catabolic process#GO:0044282;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;nucleoside phosphate catabolic process#GO:1901292;nucleotide metabolic process#GO:0009117;organophosphate catabolic process#GO:0046434 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634 phosphatase#PC00181 HUMAN|HGNC=792|UniProtKB=P17544 P17544 ATF7 PTHR19304:SF10 CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-7 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 basic leucine zipper transcription factor#PC00056 Apoptosis signaling pathway#P00006>ATF#P00302 HUMAN|HGNC=20254|UniProtKB=O60291 O60291 MGRN1 PTHR22996:SF2 MAHOGUNIN E3 UBIQUITIN-PROTEIN LIGASE MGRN1 ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740 establishment of localization#GO:0051234;transport#GO:0006810;cell surface receptor signaling pathway#GO:0007166;vacuolar transport#GO:0007034;intracellular transport#GO:0046907;biological regulation#GO:0065007;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;signal transduction#GO:0007165;establishment of localization in cell#GO:0051649;smoothened signaling pathway#GO:0007224;cellular localization#GO:0051641;localization#GO:0051179;cell communication#GO:0007154;endosome to lysosome transport#GO:0008333;lysosomal transport#GO:0007041;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789 membrane-bounded organelle#GO:0043227;early endosome#GO:0005769;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular vesicle#GO:0097708;vesicle#GO:0031982 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=16954|UniProtKB=Q92737 Q92737 RASL10A PTHR46350:SF3 RAS LIKE FAMILY 10 MEMBER B-RELATED RAS-LIKE PROTEIN FAMILY MEMBER 10A HUMAN|HGNC=2064|UniProtKB=O95833 O95833 CLIC3 PTHR43920:SF3 CHLORIDE INTRACELLULAR CHANNEL, ISOFORM A CHLORIDE INTRACELLULAR CHANNEL PROTEIN 3 monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic anion transmembrane transporter activity#GO:0008509;chloride transmembrane transporter activity#GO:0015108;passive transmembrane transporter activity#GO:0022803;chloride channel activity#GO:0005254;channel activity#GO:0015267;monoatomic anion channel activity#GO:0005253 establishment of localization#GO:0051234;localization#GO:0051179;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698;monoatomic anion transport#GO:0006820;chloride transport#GO:0006821;transport#GO:0006810 membrane#GO:0016020;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 ion channel#PC00133;transporter#PC00227 HUMAN|HGNC=2472|UniProtKB=P50461 P50461 CSRP3 PTHR24215:SF1 RHO-GTPASE-ACTIVATING PROTEIN LRG1 CYSTEINE AND GLYCINE-RICH PROTEIN 3 cytoskeletal protein binding#GO:0008092;binding#GO:0005488;structural molecule activity#GO:0005198;protein binding#GO:0005515 cellular anatomical entity morphogenesis#GO:0032989;cellular component organization or biogenesis#GO:0071840;striated muscle cell differentiation#GO:0051146;anatomical structure formation involved in morphogenesis#GO:0048646;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;animal gross anatomical part developmental process#GO:0160108;striated muscle cell development#GO:0055002;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;heart process#GO:0003015;anatomical structure morphogenesis#GO:0009653;muscle system process#GO:0003012;cell differentiation#GO:0030154;cell development#GO:0048468;actomyosin structure organization#GO:0031032;developmental process#GO:0032502;muscle contraction#GO:0006936;cellular developmental process#GO:0048869;heart contraction#GO:0060047;system process#GO:0003008;multicellular organismal process#GO:0032501;tissue development#GO:0009888;blood circulation#GO:0008015;cellular component assembly involved in morphogenesis#GO:0010927;circulatory system process#GO:0003013;organelle assembly#GO:0070925;sarcomere organization#GO:0045214;actin filament-based process#GO:0030029;cardiac muscle contraction#GO:0060048;anatomical structure development#GO:0048856;muscle tissue development#GO:0060537;supramolecular fiber organization#GO:0097435;muscle cell development#GO:0055001;muscle cell differentiation#GO:0042692;myofibril assembly#GO:0030239;actin cytoskeleton organization#GO:0030036;muscle structure development#GO:0061061;striated muscle contraction#GO:0006941 cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;nucleus#GO:0005634;Z disc#GO:0030018;contractile muscle fiber#GO:0043292;membraneless organelle#GO:0043228;sarcomere#GO:0030017;I band#GO:0031674;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membrane-bounded organelle#GO:0043227;myofibril#GO:0030016;intracellular organelle#GO:0043229 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=10386|UniProtKB=P62277 P62277 RPS13 PTHR11885:SF20 RIBOSOMAL PROTEIN S15P/S13E SMALL RIBOSOMAL SUBUNIT PROTEIN US15 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;maturation of SSU-rRNA#GO:0030490;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;ribosomal small subunit biogenesis#GO:0042274;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840 membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;small ribosomal subunit#GO:0015935;intracellular organelle#GO:0043229;preribosome#GO:0030684;nucleolus#GO:0005730;cytosolic small ribosomal subunit#GO:0022627;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;ribosome#GO:0005840;small-subunit processome#GO:0032040;organelle lumen#GO:0043233;cytosolic ribosome#GO:0022626 ribosomal protein#PC00202;translational protein#PC00263 HUMAN|HGNC=6713|UniProtKB=Q15722 Q15722 LTB4R PTHR24230:SF51 G-PROTEIN COUPLED RECEPTOR LEUKOTRIENE B4 RECEPTOR 1 peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888 signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;neuropeptide signaling pathway#GO:0007218;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021 HUMAN|HGNC=28688|UniProtKB=Q8N4L8 Q8N4L8 CCDC24 PTHR28601:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 24 COILED-COIL DOMAIN-CONTAINING PROTEIN 24 HUMAN|HGNC=853|UniProtKB=P15313 P15313 ATP6V1B1 PTHR43389:SF1 V-TYPE PROTON ATPASE SUBUNIT B V-TYPE PROTON ATPASE SUBUNIT B, KIDNEY ISOFORM regulation of pH#GO:0006885;regulation of intracellular pH#GO:0051453;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;intracellular monoatomic ion homeostasis#GO:0006873;homeostatic process#GO:0042592;transport#GO:0006810;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;proton transmembrane transport#GO:1902600;vacuolar acidification#GO:0007035;establishment of localization#GO:0051234;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;biological regulation#GO:0065007;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220 cytoplasm#GO:0005737;vacuole#GO:0005773;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;plasma membrane region#GO:0098590;cell periphery#GO:0071944;membrane#GO:0016020;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;proton-transporting V-type ATPase complex#GO:0033176;transporter complex#GO:1990351;vacuolar membrane#GO:0005774;proton-transporting two-sector ATPase complex#GO:0016469;apical part of cell#GO:0045177;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;vacuolar proton-transporting V-type ATPase, V1 domain#GO:0000221;organelle#GO:0043226;cation-transporting ATPase complex#GO:0090533;membrane protein complex#GO:0098796;apical plasma membrane#GO:0016324;ATPase dependent transmembrane transport complex#GO:0098533;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transmembrane transporter complex#GO:1902495;ATPase complex#GO:1904949;vacuolar proton-transporting V-type ATPase complex#GO:0016471;intracellular organelle#GO:0043229;catalytic complex#GO:1902494 primary active transporter#PC00068;ATP synthase#PC00002 HUMAN|HGNC=9102|UniProtKB=Q9HCM2 Q9HCM2 PLXNA4 PTHR22625:SF34 PLEXIN PLEXIN-A4 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 regulation of anatomical structure morphogenesis#GO:0022603;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;positive regulation of cell differentiation#GO:0045597;neuron differentiation#GO:0030182;nervous system development#GO:0007399;positive regulation of cell development#GO:0010720;cell morphogenesis involved in neuron differentiation#GO:0048667;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;regulation of neuron projection development#GO:0010975;signal transduction#GO:0007165;neuron projection development#GO:0031175;cellular component biogenesis#GO:0044085;neuron development#GO:0048666;regulation of biological quality#GO:0065008;axonogenesis#GO:0007409;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;synapse assembly#GO:0007416;cell morphogenesis#GO:0000902;response to stimulus#GO:0050896;regulation of cellular component organization#GO:0051128;regulation of cell shape#GO:0008360;positive regulation of multicellular organismal process#GO:0051240;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cell junction assembly#GO:0034329;negative regulation of biological process#GO:0048519;neurogenesis#GO:0022008;neuron projection guidance#GO:0097485;regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of cell differentiation#GO:0045595;neuron projection morphogenesis#GO:0048812;positive regulation of developmental process#GO:0051094;regulation of cell migration#GO:0030334;negative regulation of cellular process#GO:0048523;regulation of cell projection organization#GO:0031344;regulation of locomotion#GO:0040012;biological regulation#GO:0065007;regulation of cell adhesion#GO:0030155;multicellular organismal process#GO:0032501;regulation of cell development#GO:0060284;positive regulation of cellular process#GO:0048522;axon guidance#GO:0007411;anatomical structure development#GO:0048856;positive regulation of cell projection organization#GO:0031346;synapse organization#GO:0050808;regulation of cellular process#GO:0050794;cell junction organization#GO:0034330;cellular response to stimulus#GO:0051716;regulation of neurogenesis#GO:0050767;regulation of axonogenesis#GO:0050770;cell projection morphogenesis#GO:0048858;cell surface receptor signaling pathway#GO:0007166;plasma membrane bounded cell projection morphogenesis#GO:0120039;regulation of multicellular organismal process#GO:0051239;cellular component assembly#GO:0022607;positive regulation of axonogenesis#GO:0050772;generation of neurons#GO:0048699;positive regulation of cellular component organization#GO:0051130;signaling#GO:0023052;positive regulation of nervous system development#GO:0051962;cell projection organization#GO:0030030;cell differentiation#GO:0030154;regulation of multicellular organismal development#GO:2000026;cellular component organization#GO:0016043;cellular developmental process#GO:0048869;developmental process#GO:0032502;plasma membrane bounded cell projection organization#GO:0120036;negative regulation of cell adhesion#GO:0007162;axon development#GO:0061564;system development#GO:0048731;regulation of nervous system development#GO:0051960;cell communication#GO:0007154;regulation of cell motility#GO:2000145;positive regulation of neurogenesis#GO:0050769;regulation of developmental process#GO:0050793 membrane#GO:0016020;signaling receptor complex#GO:0043235;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=26594|UniProtKB=Q18PE1 Q18PE1 DOK7 PTHR21636:SF2 PROTEIN DOK-7 PROTEIN DOK-7 protein kinase binding#GO:0019901;enzyme binding#GO:0019899;binding#GO:0005488;kinase binding#GO:0019900;protein binding#GO:0005515 cellular process#GO:0009987;synapse organization#GO:0050808;cellular component organization#GO:0016043;neuromuscular junction development#GO:0007528;cell junction organization#GO:0034330;cellular component organization or biogenesis#GO:0071840 HUMAN|HGNC=5108|UniProtKB=P31268 P31268 HOXA7 PTHR45659:SF12 HOMEOBOX PROTEIN HOX HOMEOBOX PROTEIN HOX-A7 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;pattern specification process#GO:0007389;regulation of RNA metabolic process#GO:0051252;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regionalization#GO:0003002;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;developmental process#GO:0032502;anterior/posterior pattern specification#GO:0009952;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;multicellular organism development#GO:0007275 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119 HUMAN|HGNC=32206|UniProtKB=A6NDK9 A6NDK9 GOLGA6C PTHR10881:SF44 GOLGIN SUBFAMILY A MEMBER-RELATED GOLGIN SUBFAMILY A MEMBER 6A-RELATED cellular component organization or biogenesis#GO:0071840;endomembrane system organization#GO:0010256;organelle organization#GO:0006996;cellular component organization#GO:0016043;Golgi organization#GO:0007030;cellular process#GO:0009987 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;Golgi stack#GO:0005795;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;organelle membrane#GO:0031090;cis-Golgi network#GO:0005801;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;endomembrane system#GO:0012505;Golgi cisterna#GO:0031985;cytoplasm#GO:0005737;Golgi cis cisterna#GO:0000137 membrane traffic protein#PC00150 HUMAN|HGNC=7820|UniProtKB=Q6T4R5 Q6T4R5 NHS PTHR23039:SF5 NANCE-HORAN SYNDROME PROTEIN ACTIN REMODELING REGULATOR NHS multicellular organism development#GO:0007275;animal organ development#GO:0048513;anatomical structure development#GO:0048856;system development#GO:0048731;eye development#GO:0001654;camera-type eye development#GO:0043010;sensory organ development#GO:0007423;animal gross anatomical part developmental process#GO:0160108;lens development in camera-type eye#GO:0002088;developmental process#GO:0032502;multicellular organismal process#GO:0032501;visual system development#GO:0150063;sensory system development#GO:0048880 HUMAN|HGNC=14536|UniProtKB=Q9UIH9 Q9UIH9 KLF15 PTHR23235:SF44 KRUEPPEL-LIKE TRANSCRIPTION FACTOR KRUEPPEL-LIKE FACTOR 15 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=29528|UniProtKB=Q8WU90 Q8WU90 ZC3H15 PTHR12681:SF0 ZINC FINGER-CONTAINING PROTEIN P48ZNF ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 15 metabolic process#GO:0008152;translation#GO:0006412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;cytoplasmic translation#GO:0002181;biosynthetic process#GO:0009058 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 zinc finger transcription factor#PC00244 HUMAN|HGNC=9592|UniProtKB=P41222 P41222 PTGDS PTHR11430:SF86 LIPOCALIN PROSTAGLANDIN-H2 D-ISOMERASE extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 transfer/carrier protein#PC00219 HUMAN|HGNC=30719|UniProtKB=Q9UJT2 Q9UJT2 TSKS PTHR14351:SF1 TESTIS-SPECIFIC SERINE KINASE SUBSTRATE TESTIS-SPECIFIC SERINE KINASE SUBSTRATE multicellular organismal reproductive process#GO:0048609;developmental process#GO:0032502;spermatogenesis#GO:0007283;sexual reproduction#GO:0019953;male gamete generation#GO:0048232;gamete generation#GO:0007276;reproductive process#GO:0022414;developmental process involved in reproduction#GO:0003006 microtubule cytoskeleton#GO:0015630;cellular anatomical structure#GO:0110165;organelle#GO:0043226;centriole#GO:0005814;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=9548|UniProtKB=P35998 P35998 PSMC2 PTHR23073:SF13 26S PROTEASOME REGULATORY SUBUNIT 26S PROTEASOME REGULATORY SUBUNIT 7 isomerase activity#GO:0016853;polypeptide conformation or assembly isomerase activity#GO:0120544;catalytic activity#GO:0003824;ATP-dependent activity#GO:0140657;macromolecular conformation isomerase activity#GO:0120543 proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152 intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;endopeptidase complex#GO:1905369;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;peptidase complex#GO:1905368;proteasome complex#GO:0000502 protease#PC00190 Ubiquitin proteasome pathway#P00060>26S proteasome#P01489 HUMAN|HGNC=18736|UniProtKB=Q6P9F5 Q6P9F5 TRIM40 PTHR24103:SF564 E3 UBIQUITIN-PROTEIN LIGASE TRIM E3 UBIQUITIN LIGASE TRIM40 ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 response to external stimulus#GO:0009605;defense response#GO:0006952;innate immune response#GO:0045087;immune system process#GO:0002376;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to other organism#GO:0051707;response to stimulus#GO:0050896;defense response to other organism#GO:0098542;defense response to symbiont#GO:0140546;immune response#GO:0006955;response to biotic stimulus#GO:0009607;response to stress#GO:0006950 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=8061|UniProtKB=Q9Y6R0 Q9Y6R0 NUMBL PTHR47368:SF4 NUMB NUMB-LIKE PROTEIN biological regulation#GO:0065007;regulation of multicellular organismal process#GO:0051239;positive regulation of cell development#GO:0010720;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of cell development#GO:0060284;positive regulation of developmental process#GO:0051094;regulation of cell differentiation#GO:0045595;positive regulation of cell differentiation#GO:0045597;positive regulation of nervous system development#GO:0051962;regulation of cellular process#GO:0050794;regulation of developmental process#GO:0050793;positive regulation of neurogenesis#GO:0050769;regulation of neurogenesis#GO:0050767;regulation of biological process#GO:0050789;regulation of multicellular organismal development#GO:2000026;positive regulation of multicellular organismal process#GO:0051240;regulation of nervous system development#GO:0051960 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=24725|UniProtKB=Q96PZ2 Q96PZ2 FAM111A PTHR14389:SF14 SI:CH1073-475A24.1 SERINE PROTEASE FAM111A serine-type peptidase activity#GO:0008236;catalytic activity#GO:0003824;peptidase activity#GO:0008233;serine hydrolase activity#GO:0017171;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;DNA replication#GO:0006260;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;DNA-templated DNA replication#GO:0006261;response to stress#GO:0006950;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;replication fork processing#GO:0031297;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170 intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229 HUMAN|HGNC=41987|UniProtKB=F8W1W9 F8W1W9 NPIPB9 PTHR15438:SF4 NUCLEAR PORE COMPLEX INTERACTING PROTEIN NUCLEAR PORE COMPLEX-INTERACTING PROTEIN FAMILY MEMBER B15-RELATED HUMAN|HGNC=877|UniProtKB=P49419 P49419 ALDH7A1 PTHR43521:SF5 ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor#GO:0016620;aldehyde dehydrogenase (NAD+) activity#GO:0004029;catalytic activity#GO:0003824;oxidoreductase activity, acting on the aldehyde or oxo group of donors#GO:0016903 metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;proteinogenic amino acid metabolic process#GO:0170039;small molecule catabolic process#GO:0044282;amino acid metabolic process#GO:0006520 endomembrane system#GO:0012505;cytoplasm#GO:0005737;plasma membrane#GO:0005886;membrane#GO:0016020;cytosol#GO:0005829;cell periphery#GO:0071944;nucleus#GO:0005634;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 dehydrogenase#PC00092 5-Hydroxytryptamine degredation#P04372>Aldehyde Dehydrogenase#P04402 HUMAN|HGNC=29263|UniProtKB=Q96B67 Q96B67 ARRDC3 PTHR11188:SF49 ARRESTIN DOMAIN CONTAINING PROTEIN ARRESTIN DOMAIN-CONTAINING PROTEIN 3 vesicle#GO:0031982;cell periphery#GO:0071944;intracellular vesicle#GO:0097708;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=397|UniProtKB=P22557 P22557 ALAS2 PTHR13693:SF58 CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE 5-AMINOLEVULINATE SYNTHASE, ERYTHROID-SPECIFIC, MITOCHONDRIAL catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 primary metabolic process#GO:0044238;pigment metabolic process#GO:0042440;heme biosynthetic process#GO:0006783;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;tetrapyrrole biosynthetic process#GO:0033014;heme metabolic process#GO:0042168;biosynthetic process#GO:0009058;tetrapyrrole metabolic process#GO:0033013;metabolic process#GO:0008152;porphyrin-containing compound metabolic process#GO:0006778;pigment biosynthetic process#GO:0046148;protein metabolic process#GO:0019538;porphyrin-containing compound biosynthetic process#GO:0006779;macromolecule metabolic process#GO:0043170 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 transaminase#PC00216 HUMAN|HGNC=53443|UniProtKB=A0A1B0GVH7 A0A1B0GVH7 IQCM PTHR35978:SF1 IQ DOMAIN-CONTAINING PROTEIN M IQ DOMAIN-CONTAINING PROTEIN M HUMAN|HGNC=18448|UniProtKB=Q96FI4 Q96FI4 NEIL1 PTHR22993:SF27 FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE ENDONUCLEASE 8-LIKE 1 nuclease activity#GO:0004518;hydrolase activity#GO:0016787;DNA endonuclease activity#GO:0004520;DNA N-glycosylase activity#GO:0019104;endonuclease activity#GO:0004519;hydrolase activity, acting on glycosyl bonds#GO:0016798;catalytic activity, acting on DNA#GO:0140097;DNA nuclease activity#GO:0004536;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139;response to stress#GO:0006950;base-excision repair#GO:0006284;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;cellular response to stress#GO:0033554;DNA damage response#GO:0006974 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 DNA glycosylase#PC00010 HUMAN|HGNC=17797|UniProtKB=Q9NYL2 Q9NYL2 MAP3K20 PTHR43289:SF2 MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096 positive regulation of response to external stimulus#GO:0032103;positive regulation of cellular component biogenesis#GO:0044089;regulation of response to external stimulus#GO:0032101;positive regulation of biological process#GO:0048518;positive regulation of pattern recognition receptor signaling pathway#GO:0062208;positive regulation of immune system process#GO:0002684;positive regulation of signaling#GO:0023056;positive regulation of cellular component organization#GO:0051130;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;regulation of cellular component biogenesis#GO:0044087;regulation of cellular component organization#GO:0051128;regulation of biological process#GO:0050789;regulation of protein-containing complex assembly#GO:0043254;positive regulation of response to biotic stimulus#GO:0002833;regulation of innate immune response#GO:0045088;positive regulation of defense response#GO:0031349;positive regulation of immune response#GO:0050778;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;regulation of response to stress#GO:0080134;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;positive regulation of cellular process#GO:0048522;positive regulation of innate immune response#GO:0045089;regulation of immune response#GO:0050776;regulation of defense response#GO:0031347;regulation of cell communication#GO:0010646;regulation of response to biotic stimulus#GO:0002831;positive regulation of cell communication#GO:0010647;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;positive regulation of signal transduction#GO:0009967 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=23799|UniProtKB=Q8IYX4 Q8IYX4 DND1 PTHR21245:SF4 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN DEAD END PROTEIN HOMOLOG 1 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729 regulation of mRNA metabolic process#GO:1903311;negative regulation of RNA metabolic process#GO:0051253;mRNA stabilization#GO:0048255;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;regulation of biological quality#GO:0065008;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;RNA stabilization#GO:0043489;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of mRNA stability#GO:0043488;negative regulation of metabolic process#GO:0009892;regulation of gene silencing by regulatory ncRNA#GO:0060966;regulation of biological process#GO:0050789;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;positive regulation of gene expression#GO:0010628;regulation of biosynthetic process#GO:0009889;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of RNA catabolic process#GO:1902369;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;negative regulation of catabolic process#GO:0009895;positive regulation of biosynthetic process#GO:0009891;regulation of RNA stability#GO:0043487;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 RNA metabolism protein#PC00031 HUMAN|HGNC=28600|UniProtKB=Q8NCQ7 Q8NCQ7 PROCA1 PTHR12253:SF17 RH14732P PROTEIN PROCA1 HUMAN|HGNC=5978|UniProtKB=Q13261 Q13261 IL15RA PTHR15060:SF0 INTERLEUKIN-15 RECEPTOR SUBUNIT ALPHA INTERLEUKIN-15 RECEPTOR SUBUNIT ALPHA molecular transducer activity#GO:0060089;immune receptor activity#GO:0140375;signaling receptor activity#GO:0038023;cytokine receptor activity#GO:0004896;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;cellular response to stimulus#GO:0051716;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cytokine-mediated signaling pathway#GO:0019221;response to peptide#GO:1901652;cell communication#GO:0007154;signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;interleukin-15-mediated signaling pathway#GO:0035723;response to cytokine#GO:0034097;response to chemical#GO:0042221;cell surface receptor signaling pathway#GO:0007166 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 Interleukin signaling pathway#P00036>Receptor subunit alpha#P00992 HUMAN|HGNC=6642|UniProtKB=P25791 P25791 LMO2 PTHR45787:SF3 LD11652P RHOMBOTIN-2 transcription coactivator activity#GO:0003713;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 positive regulation of biological process#GO:0048518;cellular process#GO:0009987;embryo development#GO:0009790;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of transcription by RNA polymerase II#GO:0045944;multicellular organism development#GO:0007275;animal organ development#GO:0048513;regulation of biological process#GO:0050789;cell development#GO:0048468;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;animal gross anatomical part developmental process#GO:0160108;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;hemopoiesis#GO:0030097;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;multicellular organismal process#GO:0032501;developmental process#GO:0032502;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;embryonic organ development#GO:0048568;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=10834|UniProtKB=Q9NR46 Q9NR46 SH3GLB2 PTHR14167:SF68 SH3 DOMAIN-CONTAINING ENDOPHILIN-B2 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 scaffold/adaptor protein#PC00226 HUMAN|HGNC=11069|UniProtKB=Q9UPR5 Q9UPR5 SLC8A2 PTHR11878:SF8 SODIUM/CALCIUM EXCHANGER SODIUM_CALCIUM EXCHANGER 2 secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;antiporter activity#GO:0015297;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085 metal ion transport#GO:0030001;homeostatic process#GO:0042592;export from cell#GO:0140352;sodium ion transport#GO:0006814;calcium ion transmembrane transport#GO:0070588;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;monoatomic ion homeostasis#GO:0050801;cellular homeostasis#GO:0019725;calcium ion transport#GO:0006816;intracellular calcium ion homeostasis#GO:0006874;intracellular chemical homeostasis#GO:0055082;establishment of localization#GO:0051234;intracellular monoatomic cation homeostasis#GO:0030003;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878 cell junction#GO:0030054;postsynaptic membrane#GO:0045211;axon#GO:0030424;synaptic membrane#GO:0097060;plasma membrane region#GO:0098590;synapse#GO:0045202;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;postsynapse#GO:0098794;presynapse#GO:0098793;neuron projection#GO:0043005;cell periphery#GO:0071944 secondary carrier transporter#PC00258 HUMAN|HGNC=18900|UniProtKB=Q9BYR5 Q9BYR5 KRTAP4-2 PTHR23262:SF182 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 4-2 structural protein#PC00211 HUMAN|HGNC=6122|UniProtKB=Q92985 Q92985 IRF7 PTHR11949:SF2 INTERFERON REGULATORY FACTOR INTERFERON REGULATORY FACTOR 7 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA-binding transcription factor#PC00218;winged helix/forkhead transcription factor#PC00246 Toll receptor signaling pathway#P00054>IRF3#P01374 HUMAN|HGNC=7682|UniProtKB=O95803 O95803 NDST3 PTHR10605:SF29 HEPARAN SULFATE SULFOTRANSFERASE BIFUNCTIONAL HEPARAN SULFATE N-DEACETYLASE_N-SULFOTRANSFERASE 3 deacylase activity#GO:0160215;transferase activity#GO:0016740;catalytic activity#GO:0003824;deacetylase activity#GO:0019213;transferase activity, transferring sulphur-containing groups#GO:0016782;sulfotransferase activity#GO:0008146 carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein O-linked glycosylation#GO:0006493;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;proteoglycan biosynthetic process#GO:0030166;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;proteoglycan metabolic process#GO:0006029;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 transferase#PC00220;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=30185|UniProtKB=Q96SW2 Q96SW2 CRBN PTHR14255:SF4 CEREBLON PROTEIN CEREBLON molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;enzyme-substrate adaptor activity#GO:0140767;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 positive regulation of response to stimulus#GO:0048584;positive regulation of Wnt signaling pathway#GO:0030177;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;proteasomal protein catabolic process#GO:0010498;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;regulation of response to stimulus#GO:0048583;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111;positive regulation of signal transduction#GO:0009967;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;regulation of biological process#GO:0050789;protein metabolic process#GO:0019538;positive regulation of signaling#GO:0023056;protein catabolic process#GO:0030163;regulation of signaling#GO:0023051;modification-dependent macromolecule catabolic process#GO:0043632 Cul4-RING E3 ubiquitin ligase complex#GO:0080008;intracellular organelle#GO:0043229;transferase complex#GO:1990234;catalytic complex#GO:1902494;ubiquitin ligase complex#GO:0000151;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cullin-RING ubiquitin ligase complex#GO:0031461 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=25195|UniProtKB=Q6PEV8 Q6PEV8 FAM199X PTHR32003:SF1 PROTEIN FAM199X PROTEIN FAM199X HUMAN|HGNC=49601|UniProtKB=A0A0B4J2H0 A0A0B4J2H0 IGHV1-69D PTHR23266:SF262 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 1-69-RELATED binding#GO:0005488;antigen binding#GO:0003823 response to stimulus#GO:0050896;adaptive immune response#GO:0002250;immune response#GO:0006955;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;immune system process#GO:0002376;immune effector process#GO:0002252 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=6157|UniProtKB=Q13352 Q13352 ITGB3BP PTHR15581:SF0 CENTROMERE PROTEIN R CENTROMERE PROTEIN R membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 HUMAN|HGNC=1369|UniProtKB=Q9NS85 Q9NS85 CA10 PTHR18952:SF91 CARBONIC ANHYDRASE CARBONIC ANHYDRASE-RELATED PROTEIN 10 cell junction#GO:0030054;synapse#GO:0045202;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;dehydratase#PC00091 HUMAN|HGNC=1592|UniProtKB=P51959 P51959 CCNG1 PTHR10177:SF59 CYCLINS CYCLIN-G1 molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;cyclin-dependent protein kinase regulator activity#GO:0019914;protein kinase regulator activity#GO:0019887;enzyme regulator activity#GO:0030234;cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538 mitotic cell cycle process#GO:1903047;G1/S transition of mitotic cell cycle#GO:0000082;mitotic cell cycle phase transition#GO:0044772;cell cycle phase transition#GO:0044770;mitotic cell cycle#GO:0000278;cell cycle#GO:0007049;cellular process#GO:0009987;cell cycle process#GO:0022402;cell cycle G1/S phase transition#GO:0044843 catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex#GO:1990234;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;protein kinase complex#GO:1902911;membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226 kinase activator#PC00138 p53 pathway feedback loops 2#P04398>CYCLIN G#G04715;p53 pathway#P00059>Cyclin G#G04689;p53 pathway feedback loops 2#P04398>cyclin G#P04662 HUMAN|HGNC=6407|UniProtKB=P01116 P01116 KRAS PTHR24070:SF388 RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY GTPASE KRAS ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818 signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124;Ras protein signal transduction#GO:0007265;intracellular signal transduction#GO:0035556;regulation of cell population proliferation#GO:0042127;cell communication#GO:0007154;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;positive regulation of cell population proliferation#GO:0008284;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 small GTPase#PC00208 TGF-beta signaling pathway#P00052>Ras-GTP#P01280;VEGF signaling pathway#P00056>Ras#P01411;Integrin signalling pathway#P00034>Ras#P00916;Ras Pathway#P04393>Ras#P04547;EGF receptor signaling pathway#P00018>Ras#P00552;TGF-beta signaling pathway#P00052>Ras-GDP#P01291;PDGF signaling pathway#P00047>Ras#P01154;FGF signaling pathway#P00021>Ras#P00633;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Ras#P00869;p53 pathway feedback loops 2#P04398>Ras#P04651;Angiogenesis#P00005>Ras#P00238;PI3 kinase pathway#P00048>Ras#P01182 HUMAN|HGNC=18681|UniProtKB=Q7L014 Q7L014 DDX46 PTHR24031:SF25 RNA HELICASE ATP-DEPENDENT RNA HELICASE DDX46-RELATED macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 RNA helicase#PC00032;RNA metabolism protein#PC00031 HUMAN|HGNC=19021|UniProtKB=Q8IWZ4 Q8IWZ4 TRIM48 PTHR24103:SF632 E3 UBIQUITIN-PROTEIN LIGASE TRIM E3 UBIQUITIN-PROTEIN LIGASE TRIM48 catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630 immune response#GO:0006955;defense response to symbiont#GO:0140546;regulation of macromolecule biosynthetic process#GO:0010556;response to stress#GO:0006950;regulation of metabolic process#GO:0019222;response to biotic stimulus#GO:0009607;response to other organism#GO:0051707;biological regulation#GO:0065007;defense response to other organism#GO:0098542;regulation of gene expression#GO:0010468;defense response#GO:0006952;response to external stimulus#GO:0009605;regulation of biosynthetic process#GO:0009889;innate immune response#GO:0045087;regulation of biological process#GO:0050789;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;immune system process#GO:0002376 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=8930|UniProtKB=Q16816 Q16816 PHKG1 PTHR24347:SF386 SERINE/THREONINE-PROTEIN KINASE PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, SKELETAL MUSCLE_HEART ISOFORM protein serine/threonine kinase activity#GO:0004674;calcium/calmodulin-dependent protein kinase activity#GO:0004683;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096 biological regulation#GO:0065007;signal transduction#GO:0007165;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;energy derivation by oxidation of organic compounds#GO:0015980;metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091;response to stimulus#GO:0050896;polysaccharide metabolic process#GO:0005976;regulation of cellular process#GO:0050794;signaling#GO:0023052;carbohydrate metabolic process#GO:0005975;glycogen metabolic process#GO:0005977;primary metabolic process#GO:0044238;glucan metabolic process#GO:0044042;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;energy reserve metabolic process#GO:0006112 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;protein kinase complex#GO:1902911;serine/threonine protein kinase complex#GO:1902554;transferase complex, transferring phosphorus-containing groups#GO:0061695;transferase complex#GO:1990234;catalytic complex#GO:1902494 non-receptor serine/threonine protein kinase#PC00167 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Phosphorylase b kinase#P00716 HUMAN|HGNC=846|UniProtKB=P56385 P56385 ATP5ME PTHR12427:SF1 ATP SYNTHASE E CHAIN, MITOCHONDRIAL ATP SYNTHASE F(0) COMPLEX SUBUNIT E, MITOCHONDRIAL channel activity#GO:0015267;proton-transporting ATP synthase activity, rotational mechanism#GO:0046933;monoatomic cation transmembrane transporter activity#GO:0008324;catalytic activity#GO:0003824;proton transmembrane transporter activity#GO:0015078;passive transmembrane transporter activity#GO:0022803;transporter activity#GO:0005215;ligase activity#GO:0016874;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;proton channel activity#GO:0015252 small molecule metabolic process#GO:0044281;purine-containing compound metabolic process#GO:0072521;proton motive force-driven mitochondrial ATP synthesis#GO:0042776;purine nucleotide metabolic process#GO:0006163;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;ribonucleotide metabolic process#GO:0009259;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;ATP metabolic process#GO:0046034;ribose phosphate biosynthetic process#GO:0046390;nucleobase-containing small molecule metabolic process#GO:0055086;ribonucleoside triphosphate biosynthetic process#GO:0009201;carbohydrate derivative biosynthetic process#GO:1901137;ATP biosynthetic process#GO:0006754;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;nucleoside triphosphate metabolic process#GO:0009141;nucleoside phosphate metabolic process#GO:0006753;proton motive force-driven ATP synthesis#GO:0015986;purine nucleoside triphosphate biosynthetic process#GO:0009145;purine nucleoside triphosphate metabolic process#GO:0009144;primary metabolic process#GO:0044238;aerobic respiration#GO:0009060;organophosphate biosynthetic process#GO:0090407;cellular respiration#GO:0045333;oxidative phosphorylation#GO:0006119;purine ribonucleoside triphosphate biosynthetic process#GO:0009206;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;purine ribonucleoside triphosphate metabolic process#GO:0009205;carbohydrate derivative metabolic process#GO:1901135;nucleoside triphosphate biosynthetic process#GO:0009142;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;energy derivation by oxidation of organic compounds#GO:0015980;nucleoside phosphate biosynthetic process#GO:1901293;generation of precursor metabolites and energy#GO:0006091 membrane#GO:0016020;respiratory chain complex#GO:0098803;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;cytoplasm#GO:0005737;proton-transporting two-sector ATPase complex#GO:0016469;cation channel complex#GO:0034703;transporter complex#GO:1990351;membrane protein complex#GO:0098796;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;proton-transporting ATP synthase complex#GO:0045259;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transmembrane transporter complex#GO:1902495;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 ATP synthase#PC00002;primary active transporter#PC00068 HUMAN|HGNC=13015|UniProtKB=Q9UK12 Q9UK12 ZNF222 PTHR24377:SF612 IP01015P-RELATED ZINC FINGER PROTEIN 222 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=478|UniProtKB=P19961 P19961 AMY2B PTHR43447:SF27 ALPHA-AMYLASE ALPHA-AMYLASE 2B extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 amylase#PC00048 HUMAN|HGNC=9295|UniProtKB=Q15435 Q15435 PPP1R7 PTHR45973:SF23 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 7 phosphatase regulator activity#GO:0019208;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;protein phosphatase regulator activity#GO:0019888 chromosome segregation#GO:0007059;cell cycle process#GO:0022402;cellular process#GO:0009987;cell cycle#GO:0007049 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protein-binding activity modulator#PC00095;phosphatase modulator#PC00184 HUMAN|HGNC=1001|UniProtKB=P41182 P41182 BCL6 PTHR24399:SF29 ZINC FINGER AND BTB DOMAIN-CONTAINING B-CELL LYMPHOMA 6 PROTEIN sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription repressor activity#GO:0001217;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677 negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;immune system process#GO:0002376;regulation of multicellular organismal process#GO:0051239;regulation of response to external stimulus#GO:0032101;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of developmental process#GO:0050793;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;regulation of cell population proliferation#GO:0042127;regulation of DNA-templated transcription#GO:0006355;regulation of defense response#GO:0031347;regulation of inflammatory response#GO:0050727;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;immune response#GO:0006955;regulation of cytokine production#GO:0001817;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of response to stimulus#GO:0048583;regulation of cell differentiation#GO:0045595;regulation of response to stress#GO:0080134;negative regulation of cellular process#GO:0048523 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218 HUMAN|HGNC=25172|UniProtKB=P0C091 P0C091 FREM3 PTHR45739:SF5 MATRIX PROTEIN, PUTATIVE-RELATED FRAS1-RELATED EXTRACELLULAR MATRIX PROTEIN 3 cell-substrate adhesion#GO:0031589;multicellular organismal-level homeostasis#GO:0048871;tissue homeostasis#GO:0001894;cell-matrix adhesion#GO:0007160;cell adhesion#GO:0007155;anatomical structure homeostasis#GO:0060249;multicellular organismal process#GO:0032501;homeostatic process#GO:0042592;epithelial structure maintenance#GO:0010669;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576 HUMAN|HGNC=24913|UniProtKB=Q49AH0 Q49AH0 CDNF PTHR12990:SF9 ARMET-LIKE PROTEIN CEREBRAL DOPAMINE NEUROTROPHIC FACTOR molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;growth factor activity#GO:0008083;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545 anatomical structure development#GO:0048856;neuron development#GO:0048666;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell development#GO:0048468;cellular component organization#GO:0016043;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;neurogenesis#GO:0022008;neuron differentiation#GO:0030182;developmental process#GO:0032502;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;nervous system development#GO:0007399;neuron projection development#GO:0031175;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=19008|UniProtKB=Q9NVR0 Q9NVR0 KLHL11 PTHR24412:SF420 KELCH PROTEIN KELCH-LIKE PROTEIN 11 ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056 intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;ubiquitin ligase complex#GO:0000151;Cul3-RING ubiquitin ligase complex#GO:0031463;catalytic complex#GO:1902494;transferase complex#GO:1990234;cytoplasm#GO:0005737;cullin-RING ubiquitin ligase complex#GO:0031461;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 scaffold/adaptor protein#PC00226 HUMAN|HGNC=18365|UniProtKB=Q8IZI9 Q8IZI9 IFNL3 PTHR31943:SF1 INTERLEUKIN-28 AND 29 INTERFERON LAMBDA-2-RELATED receptor ligand activity#GO:0048018;cytokine activity#GO:0005125;signaling receptor regulator activity#GO:0030545;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546 immune system process#GO:0002376;innate immune response#GO:0045087;response to virus#GO:0009615;response to external stimulus#GO:0009605;defense response#GO:0006952;defense response to virus#GO:0051607;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;defense response to symbiont#GO:0140546;immune response#GO:0006955;response to stimulus#GO:0050896;defense response to other organism#GO:0098542;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to other organism#GO:0051707 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 interleukin superfamily#PC00128;cytokine#PC00083;intercellular signal molecule#PC00207 HUMAN|HGNC=9956|UniProtKB=Q01201 Q01201 RELB PTHR24169:SF18 NUCLEAR FACTOR NF-KAPPA-B PROTEIN TRANSCRIPTION FACTOR RELB sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 positive regulation of transcription by RNA polymerase II#GO:0045944;intracellular signaling cassette#GO:0141124;defense response to other organism#GO:0098542;positive regulation of macromolecule metabolic process#GO:0010604;response to cytokine#GO:0034097;response to chemical#GO:0042221;cellular process#GO:0009987;non-canonical NF-kappaB signal transduction#GO:0038061;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;defense response to symbiont#GO:0140546;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;response to peptide#GO:1901652;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;immune system process#GO:0002376;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of gene expression#GO:0010468;defense response#GO:0006952;response to external stimulus#GO:0009605;innate immune response#GO:0045087;regulation of biosynthetic process#GO:0009889;response to other organism#GO:0051707;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;canonical NF-kappaB signal transduction#GO:0007249;positive regulation of cellular process#GO:0048522;immune response#GO:0006955;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;intracellular signal transduction#GO:0035556;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;cell communication#GO:0007154;positive regulation of biosynthetic process#GO:0009891;positive regulation of RNA metabolic process#GO:0051254;response to external biotic stimulus#GO:0043207;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;cellular response to stimulus#GO:0051716 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;Rel homology transcription factor#PC00252;gene-specific transcriptional regulator#PC00264 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>NFkappaB#P00859;Apoptosis signaling pathway#P00006>NFkappaB#P00297 HUMAN|HGNC=24034|UniProtKB=Q8WTT2 Q8WTT2 NOC3L PTHR14428:SF5 NUCLEOLAR COMPLEX PROTEIN 3 NUCLEOLAR COMPLEX PROTEIN 3 HOMOLOG binding#GO:0005488;chromatin binding#GO:0003682 cellular process#GO:0009987;DNA replication#GO:0006260;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound metabolic process#GO:0006139;DNA replication initiation#GO:0006270;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;DNA-templated DNA replication#GO:0006261;macromolecule metabolic process#GO:0043170 membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634 HUMAN|HGNC=21703|UniProtKB=Q9BPX7 Q9BPX7 C7orf25 PTHR13379:SF0 UNCHARACTERIZED DUF1308 UPF0415 PROTEIN C7ORF25 HUMAN|HGNC=26854|UniProtKB=Q3ZCV2 Q3ZCV2 CIMAP2 PTHR34914:SF1 LYMPHOCYTE EXPANSION MOLECULE CILIARY MICROTUBULE-ASSOCIATED PROTEIN 2 HUMAN|HGNC=21297|UniProtKB=Q8TE67 Q8TE67 EPS8L3 PTHR12287:SF22 EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8-RELATED PROTEIN EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE 8-LIKE PROTEIN 3 actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;protein binding#GO:0005515 regulation of intracellular signal transduction#GO:1902531;positive regulation of cell projection organization#GO:0031346;regulation of signaling#GO:0023051;positive regulation of cellular component organization#GO:0051130;Rho protein signal transduction#GO:0007266;cell communication#GO:0007154;regulation of cell projection assembly#GO:0060491;intracellular signal transduction#GO:0035556;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of Rho protein signal transduction#GO:0035023;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of plasma membrane bounded cell projection assembly#GO:0120032;regulation of cellular component organization#GO:0051128;regulation of cellular component biogenesis#GO:0044087;regulation of cell communication#GO:0010646;signaling#GO:0023052;regulation of cell projection organization#GO:0031344;regulation of response to stimulus#GO:0048583;regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of small GTPase mediated signal transduction#GO:0051056;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of cellular component biogenesis#GO:0044089;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;regulation of signal transduction#GO:0009966 ruffle#GO:0001726;cell projection membrane#GO:0031253;ruffle membrane#GO:0032587;leading edge membrane#GO:0031256;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;cell projection#GO:0042995;membrane#GO:0016020;cell leading edge#GO:0031252;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HUMAN|HGNC=4877|UniProtKB=Q9UBX0 Q9UBX0 HESX1 PTHR46966:SF1 HOMEOBOX EXPRESSED IN ES CELLS 1 HOMEOBOX EXPRESSED IN ES CELLS 1 sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription repressor activity#GO:0001217;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;transcription cis-regulatory region binding#GO:0000976 developmental process#GO:0032502;regulation of gene expression#GO:0010468;multicellular organism development#GO:0007275;animal organ development#GO:0048513;regulation of biosynthetic process#GO:0009889;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;head development#GO:0060322;nervous system development#GO:0007399;regulation of nucleobase-containing compound metabolic process#GO:0019219;brain development#GO:0007420;multicellular organismal process#GO:0032501;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;central nervous system development#GO:0007417;regulation of cellular process#GO:0050794;forebrain development#GO:0030900 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 homeodomain transcription factor#PC00119 HUMAN|HGNC=14974|UniProtKB=Q9Y5X0 Q9Y5X0 SNX10 PTHR46209:SF2 PX DOMAIN-CONTAINING PROTEIN SORTING NEXIN-10 lipid binding#GO:0008289;phosphatidylinositol phosphate binding#GO:1901981;binding#GO:0005488;phospholipid binding#GO:0005543 cell projection organization#GO:0030030;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;vesicle organization#GO:0016050;cilium organization#GO:0044782;organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031 intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=14258|UniProtKB=Q9Y5K6 Q9Y5K6 CD2AP PTHR14167:SF23 SH3 DOMAIN-CONTAINING CD2-ASSOCIATED PROTEIN molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 plasma membrane#GO:0005886;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;cell periphery#GO:0071944;cell leading edge#GO:0031252;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HUMAN|HGNC=10019|UniProtKB=Q13546 Q13546 RIPK1 PTHR44329:SF6 SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED RECEPTOR-INTERACTING SERINE_THREONINE-PROTEIN KINASE 1 phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;MAP kinase kinase kinase activity#GO:0004709;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell death#GO:0008219;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;necroptotic process#GO:0070266;programmed cell death#GO:0012501;cell communication#GO:0007154 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Apoptosis signaling pathway#P00006>RIP#P00315 HUMAN|HGNC=25978|UniProtKB=Q9NXI6 Q9NXI6 RNF186 PTHR22791:SF28 RING-TYPE DOMAIN-CONTAINING PROTEIN E3 UBIQUITIN-PROTEIN LIGASE RNF186 catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842 post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;protein modification process#GO:0036211;primary metabolic process#GO:0044238;cellular process#GO:0009987;protein modification by small protein conjugation#GO:0032446;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=105|UniProtKB=Q6P4Q7 Q6P4Q7 CNNM4 PTHR12064:SF26 METAL TRANSPORTER CNNM METAL TRANSPORTER CNNM4 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;magnesium ion transmembrane transporter activity#GO:0015095;sodium ion transmembrane transporter activity#GO:0015081;monoatomic cation transmembrane transporter activity#GO:0008324;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075 magnesium ion transport#GO:0015693;chemical homeostasis#GO:0048878;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;inorganic ion homeostasis#GO:0098771;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;monoatomic ion homeostasis#GO:0050801;homeostatic process#GO:0042592;metal ion transport#GO:0030001 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=28578|UniProtKB=Q8IV42 Q8IV42 PSTK PTHR20873:SF0 L-SERYL-TRNA(SEC) KINASE L-SERYL-TRNA(SEC) KINASE transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;tRNA binding#GO:0000049;RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 HUMAN|HGNC=27995|UniProtKB=Q5TYX0 Q5TYX0 PRAMEF5 PTHR14224:SF112 SIMILAR TO PREFERENTIALLY EXPRESSED ANTIGEN IN MELANOMA-LIKE 3 PRAME FAMILY MEMBER 11-RELATED protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;enzyme-substrate adaptor activity#GO:0140767;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511 cullin-RING ubiquitin ligase complex#GO:0031461;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;transferase complex#GO:1990234;catalytic complex#GO:1902494;Cul2-RING ubiquitin ligase complex#GO:0031462;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;ubiquitin ligase complex#GO:0000151 HUMAN|HGNC=3094|UniProtKB=O43781 O43781 DYRK3 PTHR24058:SF35 DUAL SPECIFICITY PROTEIN KINASE DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 3 kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 regulation of cell cycle phase transition#GO:1901987;cellular component organization#GO:0016043;positive regulation of cell cycle process#GO:0090068;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;protein-containing complex disassembly#GO:0032984;regulation of cell cycle#GO:0051726;organelle disassembly#GO:1903008;cellular component disassembly#GO:0022411;organelle organization#GO:0006996;regulation of cell cycle G2/M phase transition#GO:1902749;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of cell cycle process#GO:0010564;biological regulation#GO:0065007;positive regulation of cell cycle#GO:0045787;cellular component organization or biogenesis#GO:0071840;protein-RNA complex organization#GO:0071826;protein-containing complex organization#GO:0043933 nucleus#GO:0005634;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 protein modifying enzyme#PC00260 HUMAN|HGNC=15671|UniProtKB=Q8NI38 Q8NI38 NFKBID PTHR24124:SF7 ANKYRIN REPEAT FAMILY A NF-KAPPA-B INHIBITOR DELTA regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 protein-binding activity modulator#PC00095 HUMAN|HGNC=29936|UniProtKB=Q8NA56 Q8NA56 TTC29 PTHR46630:SF2 TETRATRICOPEPTIDE REPEAT PROTEIN 29 TETRATRICOPEPTIDE REPEAT PROTEIN 29 cilium movement#GO:0003341;cellular process#GO:0009987;microtubule-based process#GO:0007017;microtubule-based movement#GO:0007018 cilium#GO:0005929;9+2 motile cilium#GO:0097729;membrane-bounded organelle#GO:0043227;organelle#GO:0043226;motile cilium#GO:0031514;cellular anatomical structure#GO:0110165;sperm flagellum#GO:0036126;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025 HUMAN|HGNC=26646|UniProtKB=Q8NAF0 Q8NAF0 ZNF579 PTHR24383:SF14 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 579 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=9985|UniProtKB=Q33E94 Q33E94 RFX4 PTHR12619:SF31 RFX TRANSCRIPTION FACTOR FAMILY TRANSCRIPTION FACTOR RFX4 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 winged helix/forkhead transcription factor#PC00246 HUMAN|HGNC=18912|UniProtKB=A8MXZ3 A8MXZ3 KRTAP9-1 PTHR23262:SF221 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 9-1 structural protein#PC00211 HUMAN|HGNC=13992|UniProtKB=Q96JY6 Q96JY6 PDLIM2 PTHR24214:SF1 PDZ AND LIM DOMAIN PROTEIN ZASP PDZ AND LIM DOMAIN PROTEIN 2 binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;protein binding#GO:0005515 cellular component organization#GO:0016043;muscle structure development#GO:0061061;actin cytoskeleton organization#GO:0030036;circulatory system development#GO:0072359;actin filament-based process#GO:0030029;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;anatomical structure development#GO:0048856;cellular process#GO:0009987;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;multicellular organismal process#GO:0032501;heart development#GO:0007507;developmental process#GO:0032502;animal organ development#GO:0048513;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275 cell-cell junction#GO:0005911;Z disc#GO:0030018;actomyosin#GO:0042641;contractile muscle fiber#GO:0043292;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;stress fiber#GO:0001725;cytoskeleton#GO:0005856;actin filament#GO:0005884;I band#GO:0031674;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;sarcomere#GO:0030017;cell junction#GO:0030054;adherens junction#GO:0005912;actin cytoskeleton#GO:0015629;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;actin filament bundle#GO:0032432;myofibril#GO:0030016;anchoring junction#GO:0070161;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=29824|UniProtKB=Q96A32 Q96A32 MYL11 PTHR23049:SF10 MYOSIN REGULATORY LIGHT CHAIN 2 MYOSIN REGULATORY LIGHT CHAIN 11 calcium ion binding#GO:0005509;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;cation binding#GO:0043169;protein binding#GO:0005515;metal ion binding#GO:0046872;cytoskeletal protein binding#GO:0008092;myosin binding#GO:0017022 muscle tissue development#GO:0060537;animal organ development#GO:0048513;anatomical structure development#GO:0048856;striated muscle tissue development#GO:0014706;developmental process#GO:0032502;muscle organ development#GO:0007517;animal gross anatomical part developmental process#GO:0160108;skeletal muscle organ development#GO:0060538;muscle structure development#GO:0061061;tissue development#GO:0009888;skeletal muscle tissue development#GO:0007519 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;myosin complex#GO:0016459;actin cytoskeleton#GO:0015629;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737 actin or actin-binding cytoskeletal protein#PC00041;cytoskeletal protein#PC00085 HUMAN|HGNC=11634|UniProtKB=P15884 P15884 TCF4 PTHR11793:SF10 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR TRANSCRIPTION FACTOR 4 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794 chromosome#GO:0005694;chromatin#GO:0000785;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;transcription regulator complex#GO:0005667;intracellular anatomical structure#GO:0005622 basic helix-loop-helix transcription factor#PC00055 CCKR signaling map#P06959>TCF7L2#P07126 HUMAN|HGNC=53889|UniProtKB=A0A075B767 A0A075B767 PPIAL4H PTHR11071:SF466 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A-LIKE 4C-RELATED intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 chaperone#PC00072 HUMAN|HGNC=12107|UniProtKB=A0A0B4J271 A0A0B4J271 TRAV12-3 PTHR19343:SF12 T CELL RECEPTOR ALPHA VARIABLE 1-2 T CELL RECEPTOR ALPHA VARIABLE 12-3 peptide binding#GO:0042277;antigen binding#GO:0003823;binding#GO:0005488 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=30813|UniProtKB=Q9NX07 Q9NX07 TRNAU1AP PTHR37457:SF2 TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1 nucleic acid binding#GO:0003676;binding#GO:0005488;tRNA binding#GO:0000049;RNA binding#GO:0003723 macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;translational elongation#GO:0006414;metabolic process#GO:0008152;post-transcriptional regulation of gene expression#GO:0010608;gene expression#GO:0010467;biological regulation#GO:0065007;biosynthetic process#GO:0009058;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein metabolic process#GO:0019538;translation#GO:0006412;regulation of macromolecule metabolic process#GO:0060255;protein biosynthetic process#GO:0160307;regulation of cellular process#GO:0050794;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=17069|UniProtKB=Q96RU3 Q96RU3 FNBP1 PTHR15735:SF13 FCH AND DOUBLE SH3 DOMAINS PROTEIN FORMIN-BINDING PROTEIN 1 regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;regulation of actin cytoskeleton organization#GO:0032956;biological regulation#GO:0065007;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;cellular component organization#GO:0016043;regulation of organelle organization#GO:0033043;cellular process#GO:0009987;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;plasma membrane organization#GO:0007009;regulation of actin filament-based process#GO:0032970 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 non-motor actin binding protein#PC00165;cytoskeletal protein#PC00085 HUMAN|HGNC=11442|UniProtKB=O15400 O15400 STX7 PTHR19957:SF90 SYNTAXIN SYNTAXIN-7 SNAP receptor activity#GO:0005484;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;vesicle organization#GO:0016050;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;membrane fusion#GO:0061025;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;organelle fusion#GO:0048284;organelle membrane fusion#GO:0090174;membrane organization#GO:0061024;cellular localization#GO:0051641;localization#GO:0051179;protein transport#GO:0015031;cellular component organization#GO:0016043;vesicle fusion#GO:0006906 synaptic vesicle#GO:0008021;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;synapse#GO:0045202;cellular anatomical structure#GO:0110165;SNARE complex#GO:0031201;organelle#GO:0043226;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;presynapse#GO:0098793;membrane#GO:0016020;secretory vesicle#GO:0099503;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;transport vesicle#GO:0030133;cell junction#GO:0030054 SNARE protein#PC00034 Parkinson disease#P00049>Syntaxin#P01215;Adrenaline and noradrenaline biosynthesis#P00001>SNARE#P00072 HUMAN|HGNC=11594|UniProtKB=Q96SF7 Q96SF7 TBX15 PTHR11267:SF98 T-BOX PROTEIN-RELATED T-BOX TRANSCRIPTION FACTOR TBX15 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;developmental process#GO:0032502;cell fate specification#GO:0001708;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;cell fate commitment#GO:0045165;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694;nucleus#GO:0005634;chromatin#GO:0000785;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 Rel homology transcription factor#PC00252;immunoglobulin fold transcription factor#PC00251 HUMAN|HGNC=17800|UniProtKB=Q9NSD9 Q9NSD9 FARSB PTHR10947:SF0 PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47 PHENYLALANINE--TRNA LIGASE BETA SUBUNIT ligase activity#GO:0016874;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a tRNA#GO:0140101 gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;amino acid metabolic process#GO:0006520;tRNA aminoacylation#GO:0043039;tRNA aminoacylation for protein translation#GO:0006418;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;amino acid activation#GO:0043038;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;protein biosynthetic process#GO:0160307;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;protein metabolic process#GO:0019538;translation#GO:0006412 catalytic complex#GO:1902494;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 HUMAN|HGNC=30841|UniProtKB=Q7Z3Y8 Q7Z3Y8 KRT27 PTHR23239:SF120 INTERMEDIATE FILAMENT KERATIN, TYPE I CYTOSKELETAL 27 structural molecule activity#GO:0005198 epidermis development#GO:0008544;developmental process#GO:0032502;cellular component organization or biogenesis#GO:0071840;animal organ development#GO:0048513;cellular developmental process#GO:0048869;morphogenesis of an epithelium#GO:0002009;organelle organization#GO:0006996;cellular process#GO:0009987;epithelium development#GO:0060429;epithelial cell differentiation#GO:0030855;multicellular organismal process#GO:0032501;tissue development#GO:0009888;cytoskeleton organization#GO:0007010;skin development#GO:0043588;intermediate filament-based process#GO:0045103;animal gross anatomical part developmental process#GO:0160108;intermediate filament organization#GO:0045109;tissue morphogenesis#GO:0048729;anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;intermediate filament cytoskeleton organization#GO:0045104;cell differentiation#GO:0030154 intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;intermediate filament#GO:0005882;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 intermediate filament#PC00129 HUMAN|HGNC=11913|UniProtKB=Q02223 Q02223 TNFRSF17 PTHR20437:SF0 TUMOR NECROSIS FACTOR RECEPTOR SUBFAMILY MEMBER 13/17 TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 17 transmembrane signal receptor#PC00197 HUMAN|HGNC=19875|UniProtKB=Q8NCW6 Q8NCW6 GALNT11 PTHR11675:SF10 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 11 protein binding#GO:0005515;polypeptide N-acetylgalactosaminyltransferase activity#GO:0004653;binding#GO:0005488;signaling receptor binding#GO:0005102;acetylgalactosaminyltransferase activity#GO:0008376;glycosyltransferase activity#GO:0016757;catalytic activity, acting on a protein#GO:0140096;UDP-glycosyltransferase activity#GO:0008194;transferase activity#GO:0016740;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycoprotein biosynthetic process#GO:0009101;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein O-linked glycosylation#GO:0006493;carbohydrate derivative metabolic process#GO:1901135;biosynthetic process#GO:0009058;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;metabolic process#GO:0008152;regulation of response to stimulus#GO:0048583;glycoprotein metabolic process#GO:0009100;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of signaling#GO:0023051;regulation of Notch signaling pathway#GO:0008593;protein metabolic process#GO:0019538 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226 transferase#PC00220;glycosyltransferase#PC00111 HUMAN|HGNC=24436|UniProtKB=Q8WYK0 Q8WYK0 ACOT12 PTHR11049:SF3 ACYL COENZYME A THIOESTER HYDROLASE ACETYL-COENZYME A THIOESTERASE thiolester hydrolase activity#GO:0016790;hydrolase activity, acting on ester bonds#GO:0016788;deacylase activity#GO:0160215;catalytic activity#GO:0003824;fatty acyl-CoA hydrolase activity#GO:0047617;acyl-CoA hydrolase activity#GO:0016289;hydrolase activity#GO:0016787 cellular process#GO:0009987;purine-containing compound metabolic process#GO:0072521;organophosphate metabolic process#GO:0019637;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;sulfur compound metabolic process#GO:0006790;nucleobase-containing compound metabolic process#GO:0006139;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;acetyl-CoA metabolic process#GO:0006084;metabolic process#GO:0008152;acyl-CoA metabolic process#GO:0006637;nucleobase-containing small molecule metabolic process#GO:0055086 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 esterase#PC00097 HUMAN|HGNC=9080|UniProtKB=P26678 P26678 PLN PTHR21194:SF1 CARDIAC PHOSPHOLAMBAN PHOSPHOLAMBAN molecular function inhibitor activity#GO:0140678;molecular function regulator activity#GO:0098772 regulation of biological quality#GO:0065008;regulation of heart contraction#GO:0008016;regulation of cellular process#GO:0050794;regulation of metal ion transport#GO:0010959;negative regulation of transport#GO:0051051;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of multicellular organismal process#GO:0051241;regulation of transport#GO:0051049;regulation of localization#GO:0032879;negative regulation of cellular process#GO:0048523;regulation of system process#GO:0044057;regulation of multicellular organismal process#GO:0051239;regulation of calcium ion transport#GO:0051924;biological regulation#GO:0065007;regulation of monoatomic ion transport#GO:0043269 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;sarcoplasmic reticulum#GO:0016529;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;sarcoplasm#GO:0016528;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 HUMAN|HGNC=33488|UniProtKB=Q6ZUT6 Q6ZUT6 CCDC9B PTHR15635:SF10 COILED-COIL DOMAIN CONTAINING PROTEIN 9 COILED-COIL DOMAIN-CONTAINING PROTEIN 9B HUMAN|HGNC=19404|UniProtKB=Q8NFA2 Q8NFA2 NOXO1 PTHR15706:SF10 SH3 MULTIPLE DOMAIN NADPH OXIDASE ORGANIZER 1 enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234 metabolic process#GO:0008152;reactive oxygen species metabolic process#GO:0072593;cellular process#GO:0009987;superoxide metabolic process#GO:0006801 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 scaffold/adaptor protein#PC00226 HUMAN|HGNC=7525|UniProtKB=O15146 O15146 MUSK PTHR24416:SF317 TYROSINE-PROTEIN KINASE RECEPTOR MUSCLE, SKELETAL RECEPTOR TYROSINE-PROTEIN KINASE molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714;protein tyrosine kinase activity#GO:0004713;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;transmembrane receptor protein kinase activity#GO:0019199;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888;protein binding#GO:0005515;Wnt-protein binding#GO:0017147;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;transferase activity#GO:0016740;kinase activity#GO:0016301;signaling receptor activity#GO:0038023 cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 membrane#GO:0016020;signaling receptor complex#GO:0043235;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=21070|UniProtKB=Q9H920 Q9H920 RNF121 PTHR13407:SF1 RNF121 PROTEIN E3 UBIQUITIN LIGASE RNF121 catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842 macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;response to stress#GO:0006950;cellular process#GO:0009987;response to chemical#GO:0042221;proteasomal protein catabolic process#GO:0010498;response to endoplasmic reticulum stress#GO:0034976;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;ERAD pathway#GO:0036503;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;catabolic process#GO:0009056;response to stimulus#GO:0050896 endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane#GO:0016020;cytoplasm#GO:0005737;endomembrane system#GO:0012505 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=17086|UniProtKB=Q9H0L4 Q9H0L4 CSTF2T PTHR45735:SF3 CLEAVAGE STIMULATION FACTOR SUBUNIT 2 CLEAVAGE STIMULATION FACTOR SUBUNIT 2 TAU VARIANT mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;mRNA cleavage factor complex#GO:0005849;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular organelle#GO:0043229;mRNA cleavage and polyadenylation specificity factor complex#GO:0005847;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 mRNA polyadenylation factor#PC00146;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HUMAN|HGNC=9033|UniProtKB=Q9UNK4 Q9UNK4 PLA2G2D PTHR11716:SF57 PHOSPHOLIPASE A2 FAMILY MEMBER GROUP IID SECRETORY PHOSPHOLIPASE A2 hydrolase activity, acting on ester bonds#GO:0016788;phospholipid binding#GO:0005543;catalytic activity#GO:0003824;cation binding#GO:0043169;hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689;lipase activity#GO:0016298;small molecule binding#GO:0036094;ion binding#GO:0043167;A2-type glycerophospholipase activity#GO:0004623;phospholipase activity#GO:0120569;glycerophospholipase activity#GO:0004620;lipid binding#GO:0008289;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;binding#GO:0005488 negative regulation of cell activation#GO:0050866;lipid metabolic process#GO:0006629;regulation of leukocyte cell-cell adhesion#GO:1903037;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;negative regulation of immune system process#GO:0002683;negative regulation of cell adhesion#GO:0007162;regulation of lymphocyte proliferation#GO:0050670;regulation of cell adhesion#GO:0030155;organophosphate metabolic process#GO:0019637;negative regulation of cell population proliferation#GO:0008285;regulation of cell population proliferation#GO:0042127;negative regulation of T cell activation#GO:0050868;phospholipid metabolic process#GO:0006644;negative regulation of leukocyte cell-cell adhesion#GO:1903038;phosphatidylglycerol metabolic process#GO:0046471;regulation of T cell proliferation#GO:0042129;regulation of immune system process#GO:0002682;regulation of cell-cell adhesion#GO:0022407;regulation of cellular process#GO:0050794;negative regulation of multicellular organismal process#GO:0051241;primary metabolic process#GO:0044238;negative regulation of T cell proliferation#GO:0042130;regulation of leukocyte proliferation#GO:0070663;metabolic process#GO:0008152;negative regulation of leukocyte activation#GO:0002695;regulation of multicellular organismal process#GO:0051239;negative regulation of lymphocyte activation#GO:0051250;negative regulation of cell-cell adhesion#GO:0022408;glycerophospholipid metabolic process#GO:0006650;phosphatidylcholine metabolic process#GO:0046470;regulation of T cell activation#GO:0050863;cellular process#GO:0009987;regulation of mononuclear cell proliferation#GO:0032944;regulation of lymphocyte activation#GO:0051249;glycerolipid metabolic process#GO:0046486;regulation of biological process#GO:0050789;regulation of cell activation#GO:0050865;negative regulation of biological process#GO:0048519;regulation of leukocyte activation#GO:0002694;phosphorus metabolic process#GO:0006793 phospholipase#PC00186 HUMAN|HGNC=30528|UniProtKB=Q96DA6 Q96DA6 DNAJC19 PTHR12763:SF56 FAMILY NOT NAMED MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM14 ATPase activator activity#GO:0001671;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772 protein localization to mitochondrion#GO:0070585;mitochondrial transport#GO:0006839;protein localization to organelle#GO:0033365;mitochondrial transmembrane transport#GO:1990542;localization#GO:0051179;transmembrane transport#GO:0055085;cellular localization#GO:0051641;protein transport#GO:0015031;macromolecule localization#GO:0033036;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;mitochondrial protein import pathway#GO:7770058;protein import into mitochondrial matrix#GO:0030150;intracellular transport#GO:0046907;protein transmembrane import into intracellular organelle#GO:0044743;intracellular protein transport#GO:0006886;protein transmembrane transport#GO:0071806;transport#GO:0006810;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;intracellular protein transmembrane transport#GO:0065002;intracellular protein localization#GO:0008104 mitochondrion#GO:0005739;organelle envelope#GO:0031967;membrane protein complex#GO:0098796;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrial membrane#GO:0031966;TIM23 mitochondrial import inner membrane translocase complex#GO:0005744;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrial inner membrane#GO:0005743;membrane-enclosed lumen#GO:0031974;membrane#GO:0016020;cytoplasm#GO:0005737;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;inner mitochondrial membrane protein complex#GO:0098800;organelle membrane#GO:0031090 HUMAN|HGNC=32690|UniProtKB=Q8NEG7 Q8NEG7 DENND6B PTHR13677:SF2 LD41638P PROTEIN DENND6B guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695 intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;intracellular organelle#GO:0043229;recycling endosome#GO:0055037;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;vesicle#GO:0031982;intracellular vesicle#GO:0097708 HUMAN|HGNC=14014|UniProtKB=Q9Y316 Q9Y316 MEMO1 PTHR11060:SF1 PROTEIN MEMO1 PROTEIN MEMO1 HUMAN|HGNC=14530|UniProtKB=Q3SY56 Q3SY56 SP6 PTHR23235:SF23 KRUEPPEL-LIKE TRANSCRIPTION FACTOR TRANSCRIPTION FACTOR SP6 DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=5606|UniProtKB=P01763 P01763 IGHV3-48 PTHR23266:SF357 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 3-11-RELATED binding#GO:0005488;antigen binding#GO:0003823 adaptive immune response#GO:0002250;response to stimulus#GO:0050896;immune response#GO:0006955;immunoglobulin mediated immune response#GO:0016064;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;immune effector process#GO:0002252;immune system process#GO:0002376 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=25569|UniProtKB=Q6ZUT1 Q6ZUT1 NKAPD1 PTHR46940:SF1 NKAP DOMAIN-CONTAINING 1 NKAP DOMAIN CONTAINING 1 HUMAN|HGNC=21338|UniProtKB=Q99811 Q99811 PRRX2 PTHR46385:SF3 PAIRED MESODERM HOMEOBOX PROTEIN 1-RELATED PAIRED MESODERM HOMEOBOX PROTEIN 2 binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 Gonadotropin-releasing hormone receptor pathway#P06664>Prx2#P06731 HUMAN|HGNC=18113|UniProtKB=Q8NHH1 Q8NHH1 TTLL11 PTHR12241:SF154 TUBULIN POLYGLUTAMYLASE TUBULIN POLYGLUTAMYLASE TTLL11 cytoskeletal protein binding#GO:0008092;ligase activity#GO:0016874;tubulin binding#GO:0015631;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;binding#GO:0005488;ligase activity, forming carbon-nitrogen bonds#GO:0016879;protein binding#GO:0005515 cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;cytoskeleton organization#GO:0007010 ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;intracellular organelle#GO:0043229;cilium#GO:0005929;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;microtubule cytoskeleton#GO:0015630;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995 microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=2873|UniProtKB=P00387 P00387 CYB5R3 PTHR19370:SF121 NADH-CYTOCHROME B5 REDUCTASE NADH-CYTOCHROME B5 REDUCTASE 3 small molecule binding#GO:0036094;anion binding#GO:0043168;binding#GO:0005488;flavin adenine dinucleotide binding#GO:0050660;ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265;oxidoreductase activity, acting on NAD(P)H#GO:0016651;catalytic activity#GO:0003824;nucleotide binding#GO:0000166;oxidoreductase activity#GO:0016491;heterocyclic compound binding#GO:1901363 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 metabolite interconversion enzyme#PC00262;reductase#PC00198 HUMAN|HGNC=13532|UniProtKB=O43711 O43711 TLX3 PTHR45921:SF1 IP01054P T-CELL LEUKEMIA HOMEOBOX PROTEIN 3 DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 developmental process#GO:0032502;regulation of gene expression#GO:0010468;animal organ development#GO:0048513;regulation of biosynthetic process#GO:0009889;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;animal gross anatomical part developmental process#GO:0160108;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=26487|UniProtKB=Q96DN2 Q96DN2 VWCE PTHR47333:SF1 VON WILLEBRAND FACTOR C AND EGF DOMAIN-CONTAINING PROTEIN VON WILLEBRAND FACTOR C AND EGF DOMAIN-CONTAINING PROTEIN response to stimulus#GO:0050896;response to virus#GO:0009615;response to external stimulus#GO:0009605;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to other organism#GO:0051707;response to biotic stimulus#GO:0009607 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=16394|UniProtKB=Q9BX69 Q9BX69 CARD6 PTHR22797:SF36 CARD6/NUCLEOLAR PROTEIN 3 CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 6 HUMAN|HGNC=32370|UniProtKB=Q14439 Q14439 GPR176 PTHR22752:SF1 G PROTEIN-COUPLED RECEPTOR G PROTEIN-COUPLED RECEPTOR 176 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway#GO:0007193;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=25568|UniProtKB=Q9NVI1 Q9NVI1 FANCI PTHR21818:SF0 BC025462 PROTEIN FANCONI ANEMIA GROUP I PROTEIN cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;response to stress#GO:0006950;regulation of protein metabolic process#GO:0051246;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;positive regulation of protein ubiquitination#GO:0031398;positive regulation of macromolecule metabolic process#GO:0010604;regulation of protein ubiquitination#GO:0031396;DNA damage response#GO:0006974;regulation of protein modification process#GO:0031399;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of protein modification by small protein conjugation or removal#GO:1903320;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;positive regulation of protein metabolic process#GO:0051247;cellular response to stress#GO:0033554;positive regulation of metabolic process#GO:0009893;regulation of post-translational protein modification#GO:1901873 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;nucleus#GO:0005634;DNA repair complex#GO:1990391;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974 HUMAN|HGNC=19665|UniProtKB=Q5T5C0 Q5T5C0 STXBP5 PTHR10241:SF22 LETHAL 2 GIANT LARVAE PROTEIN SYNTAXIN-BINDING PROTEIN 5 binding#GO:0005488;enzyme regulator activity#GO:0030234;protein binding#GO:0005515;molecular function activator activity#GO:0140677;syntaxin binding#GO:0019905;myosin binding#GO:0017022;SNARE binding#GO:0000149;enzyme activator activity#GO:0008047;cytoskeletal protein binding#GO:0008092;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function regulator activity#GO:0098772 localization within membrane#GO:0051668;Golgi vesicle transport#GO:0048193;transport#GO:0006810;exocytosis#GO:0006887;post-Golgi vesicle-mediated transport#GO:0006892;secretion by cell#GO:0032940;vesicle-mediated transport to the plasma membrane#GO:0098876;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;secretion#GO:0046903;cellular process#GO:0009987;export from cell#GO:0140352;Golgi to plasma membrane transport#GO:0006893;vesicle-mediated transport#GO:0016192 cell periphery#GO:0071944;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=1980|UniProtKB=O75339 O75339 CILP PTHR15031:SF3 CARTILAGE INTERMEDIATE LAYER PROTEIN CLIP CARTILAGE INTERMEDIATE LAYER PROTEIN 1 regulation of biological process#GO:0050789;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cell communication#GO:0010646 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=12988|UniProtKB=O14709 O14709 ZNF197 PTHR24376:SF256 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 197 regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 gene-specific transcriptional regulator#PC00264;zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=14501|UniProtKB=P82933 P82933 MRPS9 PTHR21569:SF47 RIBOSOMAL PROTEIN S9 SMALL RIBOSOMAL SUBUNIT PROTEIN US9M structural molecule activity#GO:0005198;RNA binding#GO:0003723;binding#GO:0005488;structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676 mitochondrion#GO:0005739;ribosome#GO:0005840;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;small ribosomal subunit#GO:0015935;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;organellar ribosome#GO:0000313;mitochondrial ribosome#GO:0005761;intracellular anatomical structure#GO:0005622;membrane-enclosed lumen#GO:0031974;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;mitochondrial small ribosomal subunit#GO:0005763;membraneless organelle#GO:0043228 ribosomal protein#PC00202 HUMAN|HGNC=18000|UniProtKB=Q7RTV0 Q7RTV0 PHF5A PTHR13120:SF0 PHD FINGER-LIKE DOMAIN-CONTAINING PROTEIN 5A PHD FINGER-LIKE DOMAIN-CONTAINING PROTEIN 5A RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375 spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ribonucleoprotein complex#GO:1990904;precatalytic spliceosome#GO:0071011;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;spliceosomal snRNP complex#GO:0097525;nucleus#GO:0005634;small nuclear ribonucleoprotein complex#GO:0030532;protein-containing complex#GO:0032991;U2 snRNP#GO:0005686;Sm-like protein family complex#GO:0120114;catalytic step 2 spliceosome#GO:0071013;nuclear protein-containing complex#GO:0140513 HUMAN|HGNC=18749|UniProtKB=Q13671 Q13671 RIN1 PTHR23101:SF62 RAB GDP/GTP EXCHANGE FACTOR RAS AND RAB INTERACTOR 1 guanyl-nucleotide exchange factor activity#GO:0005085;binding#GO:0005488;enzyme binding#GO:0019899;enzyme regulator activity#GO:0030234;small GTPase binding#GO:0031267;protein binding#GO:0005515;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772 vesicle#GO:0031982;cytosol#GO:0005829;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;endocytic vesicle#GO:0030139;membrane-bounded organelle#GO:0043227 protein-binding activity modulator#PC00095;guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=31957|UniProtKB=Q13066 Q13066 GAGE2B PTHR14047:SF30 P ANTIGEN FAMILY MEMBER 5-RELATED G ANTIGEN 1-RELATED HUMAN|HGNC=4489|UniProtKB=Q49SQ1 Q49SQ1 GPR33 PTHR24225:SF5 CHEMOTACTIC RECEPTOR G PROTEIN-COUPLED RECEPTOR 33-RELATED molecular transducer activity#GO:0060089;immune receptor activity#GO:0140375;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 signaling#GO:0023052;immune response-activating cell surface receptor signaling pathway#GO:0002429;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;immune response-regulating signaling pathway#GO:0002764;regulation of biological quality#GO:0065008;cell communication#GO:0007154;regulation of immune response#GO:0050776;phospholipase C-activating G protein-coupled receptor signaling pathway#GO:0007200;immune system process#GO:0002376;G protein-coupled receptor signaling pathway#GO:0007186;positive regulation of cytosolic calcium ion concentration#GO:0007204;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;positive regulation of response to stimulus#GO:0048584;activation of immune response#GO:0002253;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of immune system process#GO:0002684;immune response-activating signaling pathway#GO:0002757;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=23435|UniProtKB=Q8N4J0 Q8N4J0 CARNMT1 PTHR12303:SF14 CARNOSINE N-METHYLTRANSFERASE PROTEIN-L-HISTIDINE N-PROS-METHYLTRANSFERASE CARNMT1 transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring one-carbon groups#GO:0016741;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757 amino acid metabolic process#GO:0006520;small molecule metabolic process#GO:0044281;cellular process#GO:0009987;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HUMAN|HGNC=17907|UniProtKB=Q8IUF1 Q8IUF1 ZNG1B PTHR13748:SF31 COBW-RELATED ZINC-REGULATED GTPASE METALLOPROTEIN ACTIVATOR 1A-RELATED zinc ion binding#GO:0008270;transition metal ion binding#GO:0046914;small molecule binding#GO:0036094;binding#GO:0005488;molecular carrier activity#GO:0140104;ion binding#GO:0043167;cation binding#GO:0043169;metal ion binding#GO:0046872 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=8866|UniProtKB=O60925 O60925 PFDN1 PTHR20903:SF1 PREFOLDIN SUBUNIT 1-RELATED PREFOLDIN SUBUNIT 1 gene expression#GO:0010467;protein maturation#GO:0051604;protein folding#GO:0006457;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 chaperone#PC00072 HUMAN|HGNC=8784|UniProtKB=O76074 O76074 PDE5A PTHR11347:SF20 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE PHOSPHODIESTERASE hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;cyclic-nucleotide phosphodiesterase activity#GO:0004112;phosphoric diester hydrolase activity#GO:0008081;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578 regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;negative regulation of response to stimulus#GO:0048585;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;negative regulation of cellular process#GO:0048523;regulation of intracellular signal transduction#GO:1902531 hydrolase#PC00121;phosphodiesterase#PC00185 HUMAN|HGNC=29473|UniProtKB=Q9UK33 Q9UK33 ZNF580 PTHR24393:SF54 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 580 transcription regulator activity#GO:0140110;DNA-binding transcription activator activity#GO:0001216;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;sequence-specific DNA binding#GO:0043565;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HUMAN|HGNC=3346|UniProtKB=Q14249 Q14249 ENDOG PTHR13966:SF5 ENDONUCLEASE RELATED ENDONUCLEASE G, MITOCHONDRIAL catalytic activity, acting on RNA#GO:0140098;RNA endonuclease activity#GO:0004521;RNA nuclease activity#GO:0004540;endonuclease activity#GO:0004519;catalytic activity, acting on DNA#GO:0140097;DNA nuclease activity#GO:0004536;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;nuclease activity#GO:0004518;DNA endonuclease activity#GO:0004520 nucleobase-containing compound metabolic process#GO:0006139;apoptotic DNA fragmentation#GO:0006309;nucleobase-containing compound catabolic process#GO:0034655;nucleic acid catabolic process#GO:0141188;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;DNA metabolic process#GO:0006259;catabolic process#GO:0009056;programmed cell death#GO:0012501;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;execution phase of apoptosis#GO:0097194;cell death#GO:0008219;apoptotic process#GO:0006915;cellular component disassembly#GO:0022411;DNA catabolic process#GO:0006308 cytoplasm#GO:0005737;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;nucleus#GO:0005634;organelle membrane#GO:0031090;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 Apoptosis signaling pathway#P00006>endoG#P00279 HUMAN|HGNC=24357|UniProtKB=Q9H5V8 Q9H5V8 CDCP1 PTHR14477:SF1 CUB DOMAIN-CONTAINING PROTEIN 1 CUB DOMAIN-CONTAINING PROTEIN 1 HUMAN|HGNC=26454|UniProtKB=Q6PF06 Q6PF06 TRMT10B PTHR13563:SF19 TRNA (GUANINE-9-) METHYLTRANSFERASE TRNA METHYLTRANSFERASE 10 HOMOLOG B RNA binding#GO:0003723;tRNA binding#GO:0000049;binding#GO:0005488;nucleic acid binding#GO:0003676 RNA biosynthetic process#GO:0032774;tRNA modification#GO:0006400;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;RNA methylation#GO:0001510;methylation#GO:0032259;nucleic acid biosynthetic process#GO:0141187;macromolecule methylation#GO:0043414;RNA modification#GO:0009451;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;macromolecule biosynthetic process#GO:0009059;tRNA methylation#GO:0030488;cellular process#GO:0009987;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 RNA methyltransferase#PC00033;RNA metabolism protein#PC00031 HUMAN|HGNC=3618|UniProtKB=P31994 P31994 FCGR2B PTHR11481:SF97 IMMUNOGLOBULIN FC RECEPTOR LOW AFFINITY IMMUNOGLOBULIN GAMMA FC REGION RECEPTOR II-B-RELATED molecular transducer activity#GO:0060089;immune receptor activity#GO:0140375;protein-containing complex binding#GO:0044877;signaling receptor activity#GO:0038023;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888 positive regulation of endocytosis#GO:0045807;adaptive immune response#GO:0002250;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cytokine production#GO:0001817;immune response#GO:0006955;positive regulation of cellular process#GO:0048522;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;defense response#GO:0006952;positive regulation of gene expression#GO:0010628;cell killing#GO:0001906;positive regulation of cytokine production#GO:0001819;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;cellular response to stimulus#GO:0051716;positive regulation of biosynthetic process#GO:0009891;cell communication#GO:0007154;acute inflammatory response#GO:0002526;inflammatory response#GO:0006954;positive regulation of macromolecule metabolic process#GO:0010604;regulation of multicellular organismal process#GO:0051239;response to stress#GO:0006950;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of transport#GO:0051050;positive regulation of biological process#GO:0048518;regulation of transport#GO:0051049;regulation of localization#GO:0032879;immune effector process#GO:0002252;cell surface receptor signaling pathway#GO:0007166;regulation of endocytosis#GO:0030100;response to stimulus#GO:0050896;regulation of cellular component organization#GO:0051128;signaling#GO:0023052;leukocyte mediated cytotoxicity#GO:0001909;positive regulation of multicellular organismal process#GO:0051240;regulation of biological process#GO:0050789;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;immune system process#GO:0002376;positive regulation of cellular component organization#GO:0051130 external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=29227|UniProtKB=Q9ULI3 Q9ULI3 HEG1 PTHR24037:SF3 HEART DEVELOPMENT PROTEIN WITH EGF-LIKE DOMAINS 1 PROTEIN HEG HOMOLOG 1 system development#GO:0048731;anatomical structure development#GO:0048856;animal organ development#GO:0048513;multicellular organism development#GO:0007275;developmental process#GO:0032502;animal gross anatomical part developmental process#GO:0160108;multicellular organismal process#GO:0032501;circulatory system development#GO:0072359;heart development#GO:0007507 HUMAN|HGNC=27139|UniProtKB=Q96DD7 Q96DD7 SHISA4 PTHR31395:SF5 SHISA PROTEIN SHISA-4 scaffold/adaptor protein#PC00226 HUMAN|HGNC=11456|UniProtKB=O00338 O00338 SULT1C2 PTHR11783:SF73 SULFOTRANSFERASE SULT SULFOTRANSFERASE 1C2 transferase activity#GO:0016740;catalytic activity#GO:0003824;sulfotransferase activity#GO:0008146;transferase activity, transferring sulphur-containing groups#GO:0016782 sulfur compound metabolic process#GO:0006790;metabolic process#GO:0008152;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 transferase#PC00220;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=21256|UniProtKB=Q5TGU0 Q5TGU0 TSPO2 PTHR10057:SF4 PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR TRANSLOCATOR PROTEIN 2 outer membrane#GO:0019867;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;mitochondrial outer membrane#GO:0005741;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;membrane#GO:0016020;cytoplasm#GO:0005737;organelle outer membrane#GO:0031968 HUMAN|HGNC=11827|UniProtKB=Q07157 Q07157 TJP1 PTHR13865:SF25 TIGHT JUNCTION PROTEIN TIGHT JUNCTION PROTEIN 1 cell adhesion molecule binding#GO:0050839;binding#GO:0005488;protein binding#GO:0005515 biological regulation#GO:0065007;anatomical structure homeostasis#GO:0060249;tissue development#GO:0009888;multicellular organismal process#GO:0032501;epithelial cell differentiation#GO:0030855;epithelium development#GO:0060429;blood circulation#GO:0008015;cellular process#GO:0009987;cell-cell adhesion#GO:0098609;macromolecule localization#GO:0033036;multicellular organismal-level homeostasis#GO:0048871;intracellular protein localization#GO:0008104;system process#GO:0003008;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;endothelial cell differentiation#GO:0045446;developmental process#GO:0032502;cell-cell junction organization#GO:0045216;cell development#GO:0048468;homeostatic process#GO:0042592;cell junction organization#GO:0034330;cell differentiation#GO:0030154;cellular component organization#GO:0016043;regulation of biological quality#GO:0065008;tissue homeostasis#GO:0001894;anatomical structure development#GO:0048856;localization#GO:0051179;cell adhesion#GO:0007155;animal gross anatomical part developmental process#GO:0160108;circulatory system process#GO:0003013;protein localization to cell junction#GO:1902414 bicellular tight junction#GO:0005923;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cell-cell junction#GO:0005911;membrane#GO:0016020;cell periphery#GO:0071944;cell junction#GO:0030054;tight junction#GO:0070160;anchoring junction#GO:0070161;apical junction complex#GO:0043296 cell junction protein#PC00070;tight junction#PC00214 HUMAN|HGNC=12335|UniProtKB=Q13507 Q13507 TRPC3 PTHR10117:SF8 TRANSIENT RECEPTOR POTENTIAL CHANNEL SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 3 monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;passive transmembrane transporter activity#GO:0022803;channel activity#GO:0015267;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;alcohol binding#GO:0043178;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;binding#GO:0005488 transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;calcium ion homeostasis#GO:0055074;inorganic ion homeostasis#GO:0098771;sexual reproduction#GO:0019953;reproductive process#GO:0022414;fertilization#GO:0009566;metal ion transport#GO:0030001;homeostatic process#GO:0042592;intracellular monoatomic ion homeostasis#GO:0006873;calcium ion transmembrane transport#GO:0070588;regulation of cytosolic calcium ion concentration#GO:0051480;establishment of localization#GO:0051234;cellular homeostasis#GO:0019725;calcium ion transport#GO:0006816;intracellular calcium ion homeostasis#GO:0006874;intracellular chemical homeostasis#GO:0055082;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;transport#GO:0006810;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;single fertilization#GO:0007338;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987 membrane protein complex#GO:0098796;membrane#GO:0016020;cell periphery#GO:0071944;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;plasma membrane#GO:0005886;cation channel complex#GO:0034703;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351 ion channel#PC00133 Alzheimer disease-presenilin pathway#P00004>Capacitative calcium channels#P00124 HUMAN|HGNC=15260|UniProtKB=Q8NGP9 Q8NGP9 OR5AR1 PTHR26452:SF315 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5AR1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606;nervous system process#GO:0050877;sensory perception#GO:0007600 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=29135|UniProtKB=Q6UB98 Q6UB98 ANKRD12 PTHR24149:SF14 ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 12 ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 12 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974 HUMAN|HGNC=37265|UniProtKB=P0CJ89 P0CJ89 DUX4L6 PTHR46123:SF3 MIX-TYPE HOMEOBOX GENE 1-RELATED DOUBLE HOMEOBOX PROTEIN 1-RELATED sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=8053|UniProtKB=P53370 P53370 NUDT6 PTHR13994:SF46 NUDIX HYDROLASE RELATED NUDIX HYDROLASE 6 pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;purine nucleotide binding#GO:0017076;hydrolase activity, acting on acid anhydrides#GO:0016817;heterocyclic compound binding#GO:1901363;nucleotide binding#GO:0000166;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;small molecule binding#GO:0036094;binding#GO:0005488;hydrolase activity#GO:0016787 hydrolase#PC00121;nucleotide phosphatase#PC00173 HUMAN|HGNC=23220|UniProtKB=Q7RTX7 Q7RTX7 CATSPER4 PTHR47077:SF1 ION_TRANS DOMAIN-CONTAINING PROTEIN CATION CHANNEL SPERM-ASSOCIATED PROTEIN 4 channel activity#GO:0015267;voltage-gated calcium channel activity#GO:0005245;calcium channel activity#GO:0005262;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216 cilium movement involved in cell motility#GO:0060294;cellular process#GO:0009987;sperm capacitation#GO:0048240;microtubule-based process#GO:0007017;sperm motility#GO:0097722;sodium ion transport#GO:0006814;cell differentiation#GO:0030154;gamete generation#GO:0007276;cellular process involved in reproduction in multicellular organism#GO:0022412;cell development#GO:0048468;spermatid differentiation#GO:0048515;cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;cilium-dependent cell motility#GO:0060285;monoatomic ion transport#GO:0006811;developmental maturation#GO:0021700;male gamete generation#GO:0048232;flagellated sperm motility#GO:0030317;developmental process#GO:0032502;spermatogenesis#GO:0007283;transport#GO:0006810;cell maturation#GO:0048469;cellular developmental process#GO:0048869;establishment of localization#GO:0051234;developmental process involved in reproduction#GO:0003006;anatomical structure maturation#GO:0071695;germ cell development#GO:0007281;cell motility#GO:0048870;microtubule-based movement#GO:0007018;metal ion transport#GO:0030001;reproductive process#GO:0022414;sexual reproduction#GO:0019953;spermatid development#GO:0007286;localization#GO:0051179;monoatomic cation transport#GO:0006812;anatomical structure development#GO:0048856;multicellular organismal reproductive process#GO:0048609 plasma membrane protein complex#GO:0098797;vesicle#GO:0031982;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;motile cilium#GO:0031514;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;sperm flagellum#GO:0036126;monoatomic ion channel complex#GO:0034702;endomembrane system#GO:0012505;sperm principal piece#GO:0097228;calcium channel complex#GO:0034704;voltage-gated calcium channel complex#GO:0005891;intracellular vesicle#GO:0097708;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cilium#GO:0005929;9+2 motile cilium#GO:0097729;intracellular organelle#GO:0043229;acrosomal vesicle#GO:0001669;secretory vesicle#GO:0099503;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;CatSper complex#GO:0036128;cation channel complex#GO:0034703;transporter complex#GO:1990351 HUMAN|HGNC=9364|UniProtKB=Q92954 Q92954 PRG4 PTHR22917:SF1 HEMOPEXIN DOMAIN-CONTAINING PROTEIN PROTEOGLYCAN 4 extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical structure#GO:0110165 HUMAN|HGNC=10993|UniProtKB=Q9H2B4 Q9H2B4 SLC26A1 PTHR11814:SF31 SULFATE TRANSPORTER SULFATE ANION TRANSPORTER 1 carboxylic acid transmembrane transporter activity#GO:0046943;active transmembrane transporter activity#GO:0022804;dicarboxylic acid transmembrane transporter activity#GO:0005310;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic anion transmembrane transporter activity#GO:0008509;secondary active transmembrane transporter activity#GO:0015291;chloride transmembrane transporter activity#GO:0015108;antiporter activity#GO:0015297;bicarbonate transmembrane transporter activity#GO:0015106 chloride transport#GO:0006821;transport#GO:0006810;localization#GO:0051179;chloride transmembrane transport#GO:1902476;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;inorganic anion transport#GO:0015698;monoatomic ion transport#GO:0006811;monoatomic anion transport#GO:0006820;cellular process#GO:0009987;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227 HUMAN|HGNC=23503|UniProtKB=Q9H5Y7 Q9H5Y7 SLITRK6 PTHR45773:SF1 SLIT AND NTRK-LIKE PROTEIN 4-RELATED SLIT AND NTRK-LIKE PROTEIN 6 multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cell projection morphogenesis#GO:0048858;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;positive regulation of cellular component biogenesis#GO:0044089;nervous system development#GO:0007399;regulation of multicellular organismal process#GO:0051239;cell morphogenesis involved in neuron differentiation#GO:0048667;neuron projection development#GO:0031175;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;regulation of biological quality#GO:0065008;axonogenesis#GO:0007409;neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;regulation of synapse organization#GO:0050807;positive regulation of cellular component organization#GO:0051130;generation of neurons#GO:0048699;cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;cell differentiation#GO:0030154;regulation of cellular component organization#GO:0051128;positive regulation of nervous system development#GO:0051962;cell development#GO:0048468;regulation of cellular component biogenesis#GO:0044087;cellular component organization#GO:0016043;regulation of multicellular organismal development#GO:2000026;positive regulation of multicellular organismal process#GO:0051240;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;positive regulation of synapse assembly#GO:0051965;neuron projection morphogenesis#GO:0048812;positive regulation of developmental process#GO:0051094;developmental process#GO:0032502;multicellular organismal process#GO:0032501;regulation of synapse assembly#GO:0051963;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;axon development#GO:0061564;positive regulation of cellular process#GO:0048522;regulation of nervous system development#GO:0051960;regulation of synapse structure or activity#GO:0050803;anatomical structure development#GO:0048856;system development#GO:0048731;regulation of cell junction assembly#GO:1901888;regulation of cellular process#GO:0050794;regulation of developmental process#GO:0050793 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=23688|UniProtKB=Q86UU0 Q86UU0 BCL9L PTHR15185:SF3 BCL9 B-CELL CLL_LYMPHOMA 9-LIKE PROTEIN beta-catenin binding#GO:0008013;protein binding#GO:0005515;binding#GO:0005488 regulation of RNA metabolic process#GO:0051252;cell communication#GO:0007154;positive regulation of biosynthetic process#GO:0009891;canonical Wnt signaling pathway#GO:0060070;regulation of DNA-templated transcription#GO:0006355;regulation of transforming growth factor beta receptor signaling pathway#GO:0017015;cellular response to stimulus#GO:0051716;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092;regulation of cell communication#GO:0010646;positive regulation of RNA metabolic process#GO:0051254;Wnt signaling pathway#GO:0016055;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cellular response to growth factor stimulus#GO:0090287;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of response to stimulus#GO:0048585;positive regulation of DNA-templated transcription#GO:0045893;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;signaling#GO:0023052;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;cell surface receptor signaling pathway#GO:0007166;positive regulation of transcription by RNA polymerase II#GO:0045944;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;negative regulation of signal transduction#GO:0009968;positive regulation of macromolecule metabolic process#GO:0010604 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular organelle#GO:0043229 HUMAN|HGNC=16927|UniProtKB=Q9BYQ3 Q9BYQ3 KRTAP9-3 PTHR23262:SF210 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 9-3 structural protein#PC00211 HUMAN|HGNC=26782|UniProtKB=Q6P656 Q6P656 CFAP161 PTHR24274:SF1 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 161 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 161 plasma membrane bounded cell projection assembly#GO:0120031;organelle assembly#GO:0070925;cilium organization#GO:0044782;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cell projection assembly#GO:0030031;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cell projection organization#GO:0030030 cilium#GO:0005929;plasma membrane bounded cell projection#GO:0120025;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;motile cilium#GO:0031514;organelle#GO:0043226 structural protein#PC00211 HUMAN|HGNC=30397|UniProtKB=Q8WWX9 Q8WWX9 SELENOM PTHR13077:SF7 SELENOPROTEIN F SELENOPROTEIN M catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 endoplasmic reticulum lumen#GO:0005788;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=8872|UniProtKB=P16118 P16118 PFKFB1 PTHR10606:SF15 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE 6-PHOSPHOFRUCTO-2-KINASE_FRUCTOSE-2,6-BISPHOSPHATASE 1 phosphoric ester hydrolase activity#GO:0042578;hydrolase activity, acting on ester bonds#GO:0016788;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;transferase activity#GO:0016740;carbohydrate kinase activity#GO:0019200;phosphotransferase activity, alcohol group as acceptor#GO:0016773;hydrolase activity#GO:0016787;sugar-phosphatase activity#GO:0050308 cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;phosphorus metabolic process#GO:0006793;organophosphate metabolic process#GO:0019637;metabolic process#GO:0008152 intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;transferase complex#GO:1990234;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;cytosol#GO:0005829 hydrolase#PC00121;carbohydrate phosphatase#PC00066;phosphatase#PC00181 HUMAN|HGNC=17200|UniProtKB=Q9H3W5 Q9H3W5 LRRN3 PTHR24373:SF7 SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN LEUCINE-RICH REPEAT NEURONAL PROTEIN 3 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=24774|UniProtKB=A8MV23 A8MV23 SERPINE3 PTHR11461:SF129 SERINE PROTEASE INHIBITOR, SERPIN SERPIN E3 enzyme inhibitor activity#GO:0004857;molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866;peptidase regulator activity#GO:0061134;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414;serine-type endopeptidase inhibitor activity#GO:0004867;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HUMAN|HGNC=7699|UniProtKB=O95168 O95168 NDUFB4 PTHR15469:SF1 NADH-UBIQUINONE OXIDOREDUCTASE B15 SUBUNIT NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 4 catalytic complex#GO:1902494;respiratory chain complex I#GO:0045271;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;respiratory chain complex#GO:0098803;membrane protein complex#GO:0098796;membrane#GO:0016020;oxidoreductase complex#GO:1990204;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HUMAN|HGNC=6200|UniProtKB=Q9Y4A0 Q9Y4A0 JRKL PTHR19303:SF16 TRANSPOSON JERKY PROTEIN HOMOLOG-LIKE DNA binding#GO:0003677;binding#GO:0005488;nucleic acid binding#GO:0003676 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 viral or transposable element protein#PC00237 HUMAN|HGNC=3380|UniProtKB=Q9Y2J2 Q9Y2J2 EPB41L3 PTHR23280:SF20 4.1 G PROTEIN BAND 4.1-LIKE PROTEIN 3 plasma membrane#GO:0005886;anchoring junction#GO:0070161;cell junction#GO:0030054;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;cell-cell junction#GO:0005911;membrane#GO:0016020 actin or actin-binding cytoskeletal protein#PC00041;non-motor actin binding protein#PC00165;cytoskeletal protein#PC00085 Dopamine receptor mediated signaling pathway#P05912>EPB41#P05966 HUMAN|HGNC=17360|UniProtKB=Q96JA1 Q96JA1 LRIG1 PTHR24373:SF273 SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 nervous system process#GO:0050877;sensory perception of mechanical stimulus#GO:0050954;sensory perception#GO:0007600;system process#GO:0003008;multicellular organismal process#GO:0032501;sensory perception of sound#GO:0007605 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=19164|UniProtKB=Q9Y3M8 Q9Y3M8 STARD13 PTHR12659:SF6 RHO-TYPE GTPASE ACTIVATING PROTEIN STAR-RELATED LIPID TRANSFER PROTEIN 13 enzyme activator activity#GO:0008047;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772 regulation of response to stimulus#GO:0048583;regulation of small GTPase mediated signal transduction#GO:0051056;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;organelle organization#GO:0006996;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;cytoskeleton organization#GO:0007010;regulation of signaling#GO:0023051;actin filament-based process#GO:0030029;regulation of intracellular signal transduction#GO:1902531;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;regulation of cell communication#GO:0010646;regulation of Rho protein signal transduction#GO:0035023;regulation of cellular process#GO:0050794;actin cytoskeleton organization#GO:0030036 GTPase-activating protein#PC00257;G-protein modulator#PC00022 PDGF signaling pathway#P00047>Rho#P01174 HUMAN|HGNC=704|UniProtKB=O15143 O15143 ARPC1B PTHR10709:SF10 ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1 ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 1B cortical cytoskeleton organization#GO:0030865;actin filament-based process#GO:0030029;cellular component organization or biogenesis#GO:0071840;cortical actin cytoskeleton organization#GO:0030866;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;organelle organization#GO:0006996;cellular component organization#GO:0016043;Arp2/3 complex-mediated actin nucleation#GO:0034314;cellular process#GO:0009987;actin nucleation#GO:0045010;actin cytoskeleton organization#GO:0030036;cytoskeleton organization#GO:0007010 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;Arp2/3 protein complex#GO:0005885;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;actin cytoskeleton#GO:0015629 actin or actin-binding cytoskeletal protein#PC00041 Cytoskeletal regulation by Rho GTPase#P00016>ARP2/3#P00511;Integrin signalling pathway#P00034>Arp2/3#P00912;Huntington disease#P00029>Arp2/3 complex#P00811;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Arp2/3#P00876 HUMAN|HGNC=23052|UniProtKB=Q96KC2 Q96KC2 ARL5B PTHR11711:SF146 ADP RIBOSYLATION FACTOR-RELATED ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 5B GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;anion binding#GO:0043168;small molecule binding#GO:0036094;binding#GO:0005488;nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167;guanyl nucleotide binding#GO:0019001;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;nucleotide binding#GO:0000166;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553 localization within membrane#GO:0051668;protein transport#GO:0015031;cellular localization#GO:0051641;localization#GO:0051179;protein localization to membrane#GO:0072657;protein localization to organelle#GO:0033365;transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;protein localization to Golgi apparatus#GO:0034067;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;macromolecule localization#GO:0033036;vesicle-mediated transport#GO:0016192 membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus subcompartment#GO:0098791 G-protein#PC00020 HUMAN|HGNC=20670|UniProtKB=Q8WVJ9 Q8WVJ9 TWIST2 PTHR23349:SF70 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST TWIST-RELATED PROTEIN 2 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=20294|UniProtKB=Q5W0Q7 Q5W0Q7 USPL1 PTHR15294:SF3 RETINOVIN-RELATED SUMO-SPECIFIC ISOPEPTIDASE USPL1 protein binding#GO:0005515;binding#GO:0005488 post-translational protein modification#GO:0043687;protein modification process#GO:0036211;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;organelle organization#GO:0006996;cellular process#GO:0009987;nucleus organization#GO:0006997;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152 membraneless organelle#GO:0043228;intracellular membraneless organelle#GO:0043232;nuclear body#GO:0016604;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle lumen#GO:0043233 cysteine protease#PC00081 HUMAN|HGNC=39006|UniProtKB=Q9UQG0 Q9UQG0 ERVK-11 PTHR41694:SF3 ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN ENDOGENOUS RETROVIRUS GROUP K MEMBER 10 POL PROTEIN-RELATED RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 viral or transposable element protein#PC00237 HUMAN|HGNC=597|UniProtKB=P51693 P51693 APLP1 PTHR23103:SF13 ALZHEIMER'S DISEASE BETA-AMYLOID RELATED AMYLOID BETA PRECURSOR LIKE PROTEIN 1 G protein-coupled receptor binding#GO:0001664;signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515 neuron projection development#GO:0031175;axon development#GO:0061564;cellular process#GO:0009987;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cell morphogenesis involved in neuron differentiation#GO:0048667;developmental process#GO:0032502;neuron differentiation#GO:0030182;neuron projection morphogenesis#GO:0048812;plasma membrane bounded cell projection morphogenesis#GO:0120039;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;cell projection morphogenesis#GO:0048858;neurogenesis#GO:0022008;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cell projection organization#GO:0030030;cell differentiation#GO:0030154;central nervous system development#GO:0007417;cell morphogenesis#GO:0000902;cell development#GO:0048468;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;anatomical structure development#GO:0048856;system development#GO:0048731;neuron development#GO:0048666;axonogenesis#GO:0007409 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 protease inhibitor#PC00191 HUMAN|HGNC=18444|UniProtKB=Q7Z3Z4 Q7Z3Z4 PIWIL4 PTHR22891:SF43 EUKARYOTIC TRANSLATION INITIATION FACTOR 2C PIWI-LIKE PROTEIN 4 nucleic acid binding#GO:0003676;binding#GO:0005488;nuclease activity#GO:0004518;RNA binding#GO:0003723;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;catalytic activity, acting on RNA#GO:0140098;RNA endonuclease activity#GO:0004521 nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;gamete generation#GO:0007276;negative regulation of metabolic process#GO:0009892;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;gene expression#GO:0010467;RNA processing#GO:0006396;piRNA processing#GO:0034587;sexual reproduction#GO:0019953;multicellular organismal reproductive process#GO:0048609;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;developmental process involved in reproduction#GO:0003006;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;reproductive process#GO:0022414;RNA biosynthetic process#GO:0032774;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;spermatogenesis#GO:0007283;regulatory ncRNA-mediated gene silencing#GO:0031047;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulatory ncRNA processing#GO:0070918;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;macromolecule biosynthetic process#GO:0009059;negative regulation of macromolecule metabolic process#GO:0010605;male gamete generation#GO:0048232;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;biological regulation#GO:0065007 intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;P granule#GO:0043186;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229 translation factor#PC00223;translation initiation factor#PC00224;translational protein#PC00263 HUMAN|HGNC=9016|UniProtKB=P08F94 P08F94 PKHD1 PTHR46769:SF1 POLYCYSTIC KIDNEY AND HEPATIC DISEASE 1 (AUTOSOMAL RECESSIVE)-LIKE 1 FIBROCYSTIN HUMAN|HGNC=17183|UniProtKB=Q9H765 Q9H765 ASB8 PTHR24134:SF9 ANKYRIN REPEAT-CONTAINING PROTEIN DDB_G0279043 ANKYRIN REPEAT AND SOCS BOX PROTEIN 8 HUMAN|HGNC=9031|UniProtKB=P14555 P14555 PLA2G2A PTHR11716:SF9 PHOSPHOLIPASE A2 FAMILY MEMBER PHOSPHOLIPASE A2, MEMBRANE ASSOCIATED hydrolase activity, acting on ester bonds#GO:0016788;phospholipid binding#GO:0005543;catalytic activity#GO:0003824;cation binding#GO:0043169;hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689;small molecule binding#GO:0036094;lipase activity#GO:0016298;ion binding#GO:0043167;A2-type glycerophospholipase activity#GO:0004623;phospholipase activity#GO:0120569;glycerophospholipase activity#GO:0004620;lipid binding#GO:0008289;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;binding#GO:0005488 regulation of cell activation#GO:0050865;regulation of biological process#GO:0050789;phosphorus metabolic process#GO:0006793;regulation of leukocyte activation#GO:0002694;negative regulation of biological process#GO:0048519;regulation of lymphocyte activation#GO:0051249;glycerolipid metabolic process#GO:0046486;metabolic process#GO:0008152;negative regulation of T cell proliferation#GO:0042130;regulation of leukocyte proliferation#GO:0070663;cellular process#GO:0009987;regulation of mononuclear cell proliferation#GO:0032944;negative regulation of lymphocyte activation#GO:0051250;regulation of multicellular organismal process#GO:0051239;negative regulation of leukocyte activation#GO:0002695;regulation of T cell activation#GO:0050863;phosphatidylcholine metabolic process#GO:0046470;glycerophospholipid metabolic process#GO:0006650;negative regulation of cell-cell adhesion#GO:0022408;negative regulation of T cell activation#GO:0050868;regulation of cell population proliferation#GO:0042127;primary metabolic process#GO:0044238;negative regulation of multicellular organismal process#GO:0051241;phospholipid metabolic process#GO:0006644;negative regulation of leukocyte cell-cell adhesion#GO:1903038;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of cell-cell adhesion#GO:0022407;phosphatidylglycerol metabolic process#GO:0046471;regulation of T cell proliferation#GO:0042129;lipid metabolic process#GO:0006629;negative regulation of cellular process#GO:0048523;regulation of leukocyte cell-cell adhesion#GO:1903037;negative regulation of cell activation#GO:0050866;negative regulation of cell population proliferation#GO:0008285;organophosphate metabolic process#GO:0019637;biological regulation#GO:0065007;negative regulation of immune system process#GO:0002683;regulation of lymphocyte proliferation#GO:0050670;regulation of cell adhesion#GO:0030155;negative regulation of cell adhesion#GO:0007162 phospholipase#PC00186 HUMAN|HGNC=21285|UniProtKB=Q96PN6 Q96PN6 ADCY10 PTHR16305:SF32 TESTICULAR SOLUBLE ADENYLYL CYCLASE ADENYLATE CYCLASE TYPE 10 lyase activity#GO:0016829;molecular function regulator activity#GO:0098772;molecular sensor activity#GO:0140299;adenylate cyclase activity#GO:0004016;catalytic activity#GO:0003824;phosphorus-oxygen lyase activity#GO:0016849;cyclase activity#GO:0009975 monoatomic ion homeostasis#GO:0050801;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987;response to chemical#GO:0042221;biological regulation#GO:0065007;chemical homeostasis#GO:0048878;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;intracellular monoatomic ion homeostasis#GO:0006873;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;homeostatic process#GO:0042592;cellular response to chemical stimulus#GO:0070887;regulation of pH#GO:0006885;response to oxygen-containing compound#GO:1901700;regulation of intracellular pH#GO:0051453;regulation of biological quality#GO:0065008 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>AC#P01082;Metabotropic glutamate receptor group III pathway#P00039>AC#P01043;Endothelin signaling pathway#P00019>Adenylate cyclase#P00569;Metabotropic glutamate receptor group II pathway#P00040>AC#P01052 HUMAN|HGNC=13415|UniProtKB=Q6P2M8 Q6P2M8 PNCK PTHR24347:SF440 SERINE/THREONINE-PROTEIN KINASE CALCIUM_CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 1B catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;calmodulin binding#GO:0005516;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein binding#GO:0005515;protein kinase activity#GO:0004672;binding#GO:0005488;protein serine/threonine kinase activity#GO:0004674;calcium/calmodulin-dependent protein kinase activity#GO:0004683 cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=18063|UniProtKB=Q9NQZ5 Q9NQZ5 STARD7 PTHR19308:SF8 PHOSPHATIDYLCHOLINE TRANSFER PROTEIN STAR-RELATED LIPID TRANSFER PROTEIN 7, MITOCHONDRIAL HUMAN|HGNC=4907|UniProtKB=P31937 P31937 HIBADH PTHR22981:SF85 3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED 3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824 small molecule catabolic process#GO:0044282;amino acid metabolic process#GO:0006520;proteinogenic amino acid metabolic process#GO:0170039;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 dehydrogenase#PC00092 HUMAN|HGNC=28451|UniProtKB=Q6UXF1 Q6UXF1 TMEM108 PTHR28673:SF1 TRANSMEMBRANE PROTEIN 108 TRANSMEMBRANE PROTEIN 108 cell morphogenesis#GO:0000902;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell development#GO:0048468;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cellular localization#GO:0051641;neuron development#GO:0048666;developmental growth involved in morphogenesis#GO:0060560;neuron projection extension#GO:1990138;animal gross anatomical part developmental process#GO:0160108;retrograde axonal transport#GO:0008090;postsynaptic density organization#GO:0097106;generation of neurons#GO:0048699;microtubule-based transport#GO:0099111;nervous system development#GO:0007399;neuron projection development#GO:0031175;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;cell growth#GO:0016049;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;cell projection morphogenesis#GO:0048858;growth#GO:0040007;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;cell junction organization#GO:0034330;microtubule-based movement#GO:0007018;developmental cell growth#GO:0048588;postsynapse organization#GO:0099173;anatomical structure development#GO:0048856;localization#GO:0051179;postsynaptic specialization organization#GO:0099084;system development#GO:0048731;axonal transport#GO:0098930;synapse organization#GO:0050808;multicellular organismal process#GO:0032501;cytoskeleton-dependent intracellular transport#GO:0030705;plasma membrane bounded cell projection organization#GO:0120036;axo-dendritic transport#GO:0008088;cellular developmental process#GO:0048869;developmental growth#GO:0048589;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;neurogenesis#GO:0022008;intracellular transport#GO:0046907;neuron projection morphogenesis#GO:0048812;transport#GO:0006810;developmental process#GO:0032502 cytoplasm#GO:0005737;postsynaptic specialization#GO:0099572;endomembrane system#GO:0012505;neuron to neuron synapse#GO:0098984;cytoplasmic vesicle membrane#GO:0030659;neuron projection#GO:0043005;vesicle membrane#GO:0012506;membrane#GO:0016020;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;cell junction#GO:0030054;cell projection#GO:0042995;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;asymmetric synapse#GO:0032279;synapse#GO:0045202;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;postsynapse#GO:0098794;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;axon#GO:0030424;intracellular organelle#GO:0043229;endosome membrane#GO:0010008;endosome#GO:0005768;postsynaptic density#GO:0014069 HUMAN|HGNC=28512|UniProtKB=A6NEQ2 A6NEQ2 FAM181B PTHR33766:SF2 PROTEIN FAM181B PROTEIN FAM181B HUMAN|HGNC=29059|UniProtKB=Q5JU85 Q5JU85 IQSEC2 PTHR10663:SF314 GUANYL-NUCLEOTIDE EXCHANGE FACTOR IQ MOTIF AND SEC7 DOMAIN-CONTAINING PROTEIN 2 regulation of biological quality#GO:0065008;regulation of localization#GO:0032879;regulation of transport#GO:0051049;regulation of signaling#GO:0023051;regulation of endocytosis#GO:0030100;regulation of cell communication#GO:0010646;modulation of chemical synaptic transmission#GO:0050804;biological regulation#GO:0065007;regulation of trans-synaptic signaling#GO:0099177;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of receptor-mediated endocytosis#GO:0048259;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789 postsynapse#GO:0098794;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;asymmetric synapse#GO:0032279;postsynaptic density#GO:0014069;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;postsynaptic density membrane#GO:0098839;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;neuron to neuron synapse#GO:0098984;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;synaptic membrane#GO:0097060;cell junction#GO:0030054 guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=12929|UniProtKB=P35227 P35227 PCGF2 PTHR10825:SF31 RING FINGER DOMAIN-CONTAINING, POLYCOMB GROUP COMPONENT POLYCOMB GROUP RING FINGER PROTEIN 2 chromatin binding#GO:0003682;binding#GO:0005488 negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892 intracellular protein-containing complex#GO:0140535;PRC1 complex#GO:0035102;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234;protein-containing complex#GO:0032991;nucleus#GO:0005634;PcG protein complex#GO:0031519;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;nuclear ubiquitin ligase complex#GO:0000152;organelle#GO:0043226;cellular anatomical structure#GO:0110165 histone modifying enzyme#PC00261 HUMAN|HGNC=17793|UniProtKB=Q9UEU0 Q9UEU0 VTI1B PTHR21230:SF64 VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1B SNAP receptor activity#GO:0005484;protein binding#GO:0005515;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;SNARE binding#GO:0000149 process utilizing autophagic mechanism#GO:0061919;post-Golgi vesicle-mediated transport#GO:0006892;cellular localization#GO:0051641;cellular component organization#GO:0016043;cytosolic transport#GO:0016482;Golgi vesicle transport#GO:0048193;metabolic process#GO:0008152;vesicle organization#GO:0016050;endosomal transport#GO:0016197;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;autophagy#GO:0006914;establishment of localization in cell#GO:0051649;organelle organization#GO:0006996;organelle membrane fusion#GO:0090174;endomembrane system organization#GO:0010256;vesicle-mediated transport#GO:0016192;organelle fusion#GO:0048284;Golgi to vacuole transport#GO:0006896;localization#GO:0051179;intra-Golgi vesicle-mediated transport#GO:0006891;Golgi organization#GO:0007030;vesicle fusion#GO:0006906;catabolic process#GO:0009056;transport#GO:0006810;vacuolar transport#GO:0007034;intracellular transport#GO:0046907;establishment of localization#GO:0051234;retrograde transport, endosome to Golgi#GO:0042147;membrane fusion#GO:0061025;macroautophagy#GO:0016236;membrane organization#GO:0061024 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;late endosome#GO:0005770;endoplasmic reticulum#GO:0005783;late endosome membrane#GO:0031902;bounding membrane of organelle#GO:0098588;intracellular vesicle#GO:0097708;coated vesicle membrane#GO:0030662;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endosome#GO:0005768;endosome membrane#GO:0010008;organelle subcompartment#GO:0031984;coated vesicle#GO:0030135;vesicle membrane#GO:0012506;membrane#GO:0016020;transport vesicle#GO:0030133;endomembrane system#GO:0012505;transport vesicle membrane#GO:0030658;ER to Golgi transport vesicle membrane#GO:0012507;Golgi apparatus#GO:0005794;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;vesicle#GO:0031982;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;SNARE complex#GO:0031201;endoplasmic reticulum subcompartment#GO:0098827;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;COPII-coated ER to Golgi transport vesicle#GO:0030134 SNARE protein#PC00034;membrane traffic protein#PC00150 Adrenaline and noradrenaline biosynthesis#P00001>SNARE#P00072 HUMAN|HGNC=27160|UniProtKB=Q6IC83 Q6IC83 C22orf42 PTHR15880:SF1 ASPARTATE-RICH PROTEIN 1 CHROMOSOME 22 OPEN READING FRAME 42 HUMAN|HGNC=24457|UniProtKB=Q8N9I9 Q8N9I9 DTX3 PTHR12622:SF35 DELTEX-RELATED E3 UBIQUITIN-PROTEIN LIGASE DTX3 catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787 macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;cell surface receptor signaling pathway#GO:0007166;Notch signaling pathway#GO:0007219;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;cellular process#GO:0009987;signal transduction#GO:0007165;proteasomal protein catabolic process#GO:0010498;biological regulation#GO:0065007;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;cell communication#GO:0007154;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;modification-dependent protein catabolic process#GO:0019941;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;catabolic process#GO:0009056;signaling#GO:0023052 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=20887|UniProtKB=Q4AE62 Q4AE62 QTMAN PTHR13615:SF3 GLYCOSYLTRANSFERASE-LIKE 1 TRNA-QUEUOSINE ALPHA-MANNOSYLTRANSFERASE glycosyltransferase#PC00111;transferase#PC00220 HUMAN|HGNC=25715|UniProtKB=Q5JXC2 Q5JXC2 MIIP PTHR34831:SF1 MIGRATION AND INVASION-INHIBITORY PROTEIN MIGRATION AND INVASION-INHIBITORY PROTEIN HUMAN|HGNC=14770|UniProtKB=Q8NGN7 Q8NGN7 OR10D4P PTHR26453:SF19 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 10D4-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 system process#GO:0003008;nervous system process#GO:0050877;sensory perception#GO:0007600;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;response to stimulus#GO:0050896;response to chemical#GO:0042221;detection of chemical stimulus#GO:0009593;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=27145|UniProtKB=C9JJ37 C9JJ37 BTBD19 PTHR46965:SF1 BTB/POZ DOMAIN-CONTAINING PROTEIN 19 BTB_POZ DOMAIN-CONTAINING PROTEIN 19 HUMAN|HGNC=27302|UniProtKB=Q5T440 Q5T440 IBA57 PTHR22602:SF0 IRON-SULFUR CLUSTER ASSEMBLY FACTOR CAF17/IBA57, MITOCHONDRIAL IRON-SULFUR CLUSTER ASSEMBLY FACTOR IBA57, MITOCHONDRIAL intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=25401|UniProtKB=Q8TCP9 Q8TCP9 FAM200A PTHR45935:SF1 PROTEIN ZBED8-RELATED PROTEIN FAM200A HUMAN|HGNC=1494|UniProtKB=Q15699 Q15699 ALX1 PTHR24329:SF359 HOMEOBOX PROTEIN ARISTALESS ALX HOMEOBOX PROTEIN 1 transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription activator activity#GO:0001216;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 positive regulation of RNA metabolic process#GO:0051254;animal organ morphogenesis#GO:0009887;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;embryo development ending in birth or egg hatching#GO:0009792;embryonic organ development#GO:0048568;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;skeletal system morphogenesis#GO:0048705;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;negative regulation of biological process#GO:0048519;cell development#GO:0048468;negative regulation of metabolic process#GO:0009892;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;chordate embryonic development#GO:0043009;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;neuron development#GO:0048666;negative regulation of DNA-templated transcription#GO:0045892;positive regulation of metabolic process#GO:0009893;skeletal system development#GO:0001501;positive regulation of macromolecule biosynthetic process#GO:0010557;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;negative regulation of macromolecule biosynthetic process#GO:0010558;embryo development#GO:0009790;nervous system development#GO:0007399;positive regulation of macromolecule metabolic process#GO:0010604;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;neuron differentiation#GO:0030182;positive regulation of transcription by RNA polymerase II#GO:0045944;animal organ development#GO:0048513;multicellular organism development#GO:0007275;embryonic morphogenesis#GO:0048598 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=5037|UniProtKB=O14979 O14979 HNRNPDL PTHR48033:SF2 RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN D-LIKE nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255 organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;chromatin#GO:0000785;nucleus#GO:0005634;membraneless organelle#GO:0043228 RNA metabolism protein#PC00031 HUMAN|HGNC=30387|UniProtKB=Q7Z5L0 Q7Z5L0 VMO1 PTHR18841:SF2 VITELLINE MEMBRANE OUTER LAYER PROTEIN I-RELATED VITELLINE MEMBRANE OUTER LAYER PROTEIN 1 HOMOLOG cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=9347|UniProtKB=Q13029 Q13029 PRDM2 PTHR16515:SF37 PR DOMAIN ZINC FINGER PROTEIN PR DOMAIN ZINC FINGER PROTEIN 2-RELATED DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700 regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244;DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=13753|UniProtKB=Q9BXM9 Q9BXM9 FSD1L PTHR24099:SF8 E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED FSD1-LIKE PROTEIN ubiquitin-protein ligase#PC00234 HUMAN|HGNC=14154|UniProtKB=Q96S06 Q96S06 LMF1 PTHR14463:SF10 LIPASE MATURATION FACTOR LIPASE MATURATION FACTOR 1 metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058 membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=17397|UniProtKB=O75531 O75531 BANF1 PTHR47507:SF7 BARRIER TO AUTOINTEGRATION FACTOR 2 BARRIER-TO-AUTOINTEGRATION FACTOR binding#GO:0005488;nucleic acid binding#GO:0003676;DNA binding#GO:0003677 cellular component organization or biogenesis#GO:0071840;chromosome organization#GO:0051276;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;nucleus#GO:0005634;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;condensed chromosome#GO:0000793;intracellular organelle#GO:0043229 HUMAN|HGNC=3325|UniProtKB=P41970 P41970 ELK3 PTHR11849:SF172 ETS ETS DOMAIN-CONTAINING PROTEIN ELK-3 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110 cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;cellular process#GO:0009987;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;developmental process#GO:0032502 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 winged helix/forkhead transcription factor#PC00246;DNA-binding transcription factor#PC00218 Interleukin signaling pathway#P00036>ELK#P00962 HUMAN|HGNC=23452|UniProtKB=Q5VXI9 Q5VXI9 LIPN PTHR11005:SF16 LYSOSOMAL ACID LIPASE-RELATED LIPASE MEMBER N lipase activity#GO:0016298;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787 metabolic process#GO:0008152;primary metabolic process#GO:0044238;lipid metabolic process#GO:0006629;cellular process#GO:0009987 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229 hydrolase#PC00121;lipase#PC00143 HUMAN|HGNC=19374|UniProtKB=O15226 O15226 NKRF PTHR16148:SF15 NF-KAPPA-B-REPRESSING FACTOR-RELATED NF-KAPPA-B-REPRESSING FACTOR DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;molecular function regulator activity#GO:0098772;ATPase activator activity#GO:0001671;DNA-binding transcription activator activity#GO:0001216;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;molecular function activator activity#GO:0140677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=16118|UniProtKB=Q3SXZ7 Q3SXZ7 TTLL9 PTHR12241:SF39 TUBULIN POLYGLUTAMYLASE TUBULIN POLYGLUTAMYLASE TTLL9-RELATED binding#GO:0005488;ligase activity, forming carbon-nitrogen bonds#GO:0016879;protein binding#GO:0005515;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;ligase activity#GO:0016874;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 cytoskeleton organization#GO:0007010;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cilium#GO:0005929;cytoskeleton#GO:0005856;ciliary basal body#GO:0036064;microtubule organizing center#GO:0005815;plasma membrane bounded cell projection#GO:0120025;intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;microtubule cytoskeleton#GO:0015630 microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=7708|UniProtKB=O75306 O75306 NDUFS2 PTHR11993:SF48 NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL NADH dehydrogenase activity#GO:0003954;electron transfer activity#GO:0009055;oxidoreductase activity, acting on NAD(P)H#GO:0016651;monoatomic cation transmembrane transporter activity#GO:0008324;proton transmembrane transporter activity#GO:0015078;catalytic activity#GO:0003824;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic ion transmembrane transporter activity#GO:0015075;oxidoreductase activity#GO:0016491;active transmembrane transporter activity#GO:0022804;oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor#GO:0016655;primary active transmembrane transporter activity#GO:0015399 mitochondrial ATP synthesis coupled electron transport#GO:0042775;respiratory electron transport chain#GO:0022904;cellular process#GO:0009987;electron transport chain#GO:0022900;aerobic respiration#GO:0009060;oxidative phosphorylation#GO:0006119;ATP synthesis coupled electron transport#GO:0042773;cellular respiration#GO:0045333;energy derivation by oxidation of organic compounds#GO:0015980;generation of precursor metabolites and energy#GO:0006091;mitochondrial electron transport, NADH to ubiquinone#GO:0006120;metabolic process#GO:0008152;aerobic electron transport chain#GO:0019646 transporter complex#GO:1990351;organelle membrane#GO:0031090;respiratory chain complex I#GO:0045271;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;oxidoreductase complex#GO:1990204;respiratory chain complex#GO:0098803;mitochondrial membrane#GO:0031966;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;transmembrane transporter complex#GO:1902495;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;membrane protein complex#GO:0098796;mitochondrion#GO:0005739 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=23410|UniProtKB=Q969X1 Q969X1 TMBIM1 PTHR23291:SF35 BAX INHIBITOR-RELATED PROTEIN LIFEGUARD 3 calcium ion transmembrane transporter activity#GO:0015085;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;passive transmembrane transporter activity#GO:0022803;calcium channel activity#GO:0005262;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261;metal ion transmembrane transporter activity#GO:0046873 response to unfolded protein#GO:0006986;negative regulation of cell communication#GO:0010648;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;response to topologically incorrect protein#GO:0035966;signaling#GO:0023052;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;regulation of biological process#GO:0050789;regulation of apoptotic process#GO:0042981;negative regulation of signal transduction#GO:0009968;response to stress#GO:0006950;negative regulation of neuron apoptotic process#GO:0043524;regulation of neuron apoptotic process#GO:0043523;cellular process#GO:0009987;negative regulation of programmed cell death#GO:0043069;signal transduction#GO:0007165;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;response to endoplasmic reticulum stress#GO:0034976;cellular response to unfolded protein#GO:0034620;cellular response to topologically incorrect protein#GO:0035967;regulation of apoptotic signaling pathway#GO:2001233;negative regulation of apoptotic signaling pathway#GO:2001234;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of extrinsic apoptotic signaling pathway#GO:2001236;cellular response to stimulus#GO:0051716;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;negative regulation of response to stimulus#GO:0048585;negative regulation of apoptotic process#GO:0043066;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;endoplasmic reticulum unfolded protein response#GO:0030968;negative regulation of extrinsic apoptotic signaling pathway#GO:2001237 organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HUMAN|HGNC=1350|UniProtKB=Q8WWH4 Q8WWH4 ASZ1 PTHR24157:SF3 ANKYRIN REPEAT, SAM AND BASIC LEUCINE ZIPPER DOMAIN-CONTAINING PROTEIN 1 ANKYRIN REPEAT, SAM AND BASIC LEUCINE ZIPPER DOMAIN-CONTAINING PROTEIN 1 developmental process involved in reproduction#GO:0003006;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;gamete generation#GO:0007276;regulation of macromolecule metabolic process#GO:0060255;reproductive process#GO:0022414;negative regulation of metabolic process#GO:0009892;sexual reproduction#GO:0019953;multicellular organismal reproductive process#GO:0048609;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of macromolecule metabolic process#GO:0010605;male gamete generation#GO:0048232;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;spermatogenesis#GO:0007283;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 intracellular anatomical structure#GO:0005622;P granule#GO:0043186;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;organelle#GO:0043226;ribonucleoprotein granule#GO:0035770;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464 HUMAN|HGNC=29544|UniProtKB=Q8WTZ4 Q8WTZ4 CA5BP1 PTHR18952:SF81 CARBONIC ANHYDRASE CARBONIC ANHYDRASE 13-RELATED catalytic activity#GO:0003824;carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;hydro-lyase activity#GO:0016836 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;dehydratase#PC00091 HUMAN|HGNC=19102|UniProtKB=O95786 O95786 RIGI PTHR14074:SF16 HELICASE WITH DEATH DOMAIN-RELATED ANTIVIRAL INNATE IMMUNE RESPONSE RECEPTOR RIG-I transition metal ion binding#GO:0046914;double-stranded RNA binding#GO:0003725;ion binding#GO:0043167;binding#GO:0005488;nucleic acid binding#GO:0003676;small molecule binding#GO:0036094;cation binding#GO:0043169;RNA binding#GO:0003723;metal ion binding#GO:0046872;zinc ion binding#GO:0008270;single-stranded RNA binding#GO:0003727 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=25530|UniProtKB=Q9NVX0 Q9NVX0 HAUS2 PTHR16039:SF2 HAUS AUGMIN-LIKE COMPLEX SUBUNIT 2 HAUS AUGMIN-LIKE COMPLEX SUBUNIT 2 microtubule organizing center organization#GO:0031023;protein-containing complex organization#GO:0043933;microtubule-based process#GO:0007017;microtubule polymerization#GO:0046785;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;chromosome segregation#GO:0007059;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;microtubule polymerization or depolymerization#GO:0031109;organelle organization#GO:0006996;spindle assembly#GO:0051225;supramolecular fiber organization#GO:0097435;microtubule cytoskeleton organization#GO:0000226;organelle assembly#GO:0070925;protein-containing complex assembly#GO:0065003;centrosome cycle#GO:0007098;protein polymerization#GO:0051258;cell cycle process#GO:0022402;cell cycle#GO:0007049;microtubule nucleation#GO:0007020;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694 supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;centrosome#GO:0005813;spindle#GO:0005819;microtubule organizing center#GO:0005815;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitotic spindle#GO:0072686;HAUS complex#GO:0070652;spindle microtubule#GO:0005876;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;intracellular organelle#GO:0043229 HUMAN|HGNC=17772|UniProtKB=Q99757 Q99757 TXN2 PTHR43601:SF39 THIOREDOXIN, MITOCHONDRIAL THIOREDOXIN, MITOCHONDRIAL cellular homeostasis#GO:0019725;cell redox homeostasis#GO:0045454;homeostatic process#GO:0042592 mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 Hypoxia response via HIF activation#P00030>Thioredoxin#P00825 HUMAN|HGNC=1368|UniProtKB=P00915 P00915 CA1 PTHR18952:SF282 CARBONIC ANHYDRASE CARBONIC ANHYDRASE 1 hydro-lyase activity#GO:0016836;carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;catalytic activity#GO:0003824 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 dehydratase#PC00091;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=28835|UniProtKB=Q6NXR0 Q6NXR0 IRGC PTHR32341:SF10 INTERFERON-INDUCIBLE GTPASE INTERFERON-INDUCIBLE GTPASE 5 hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787 HUMAN|HGNC=25704|UniProtKB=Q9H7M6 Q9H7M6 ZSWIM4 PTHR22619:SF4 ZINC FINGER SWIM DOMAIN CONTAINING PROTEIN 4, 5, 6 ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 4 catalytic complex#GO:1902494;transferase complex#GO:1990234;Cul2-RING ubiquitin ligase complex#GO:0031462;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535 HUMAN|HGNC=3226|UniProtKB=P98172 P98172 EFNB1 PTHR11304:SF17 EPHRIN EPHRIN-B1 binding#GO:0005488;signaling receptor binding#GO:0005102;protein binding#GO:0005515 cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cell differentiation#GO:0030154;cell projection organization#GO:0030030;response to stimulus#GO:0050896;cell morphogenesis#GO:0000902;signaling#GO:0023052;cell development#GO:0048468;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;axonogenesis#GO:0007409;neuron development#GO:0048666;neuron projection development#GO:0031175;signal transduction#GO:0007165;cellular process#GO:0009987;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;neuron differentiation#GO:0030182;cell surface receptor signaling pathway#GO:0007166;plasma membrane bounded cell projection morphogenesis#GO:0120039;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cell projection morphogenesis#GO:0048858;cellular response to stimulus#GO:0051716;ephrin receptor signaling pathway#GO:0048013;regulation of cellular process#GO:0050794;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cell communication#GO:0007154;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;system development#GO:0048731;axon guidance#GO:0007411;axon development#GO:0061564;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;cellular developmental process#GO:0048869;neuron projection guidance#GO:0097485;neurogenesis#GO:0022008 cellular anatomical structure#GO:0110165;glutamatergic synapse#GO:0098978;synapse#GO:0045202;plasma membrane region#GO:0098590;presynaptic membrane#GO:0042734;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;presynapse#GO:0098793;cell junction#GO:0030054;synaptic membrane#GO:0097060 intercellular signal molecule#PC00207;membrane-bound signaling molecule#PC00152 Angiogenesis#P00005>Eph#P00239 HUMAN|HGNC=28759|UniProtKB=Q9H5J8 Q9H5J8 TAF1D PTHR14562:SF3 TATA BOX-BINDING PROTEIN ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT D TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT D cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 HUMAN|HGNC=12118|UniProtKB=A0A0B4J279 A0A0B4J279 TRAV21 PTHR19433:SF52 T-CELL RECEPTOR ALPHA CHAIN V REGION-RELATED T CELL RECEPTOR ALPHA VARIABLE 21 response to bacterium#GO:0009617;response to biotic stimulus#GO:0009607;response to stimulus#GO:0050896;response to external biotic stimulus#GO:0043207;response to external stimulus#GO:0009605;biological process involved in interspecies interaction between organisms#GO:0044419;response to other organism#GO:0051707 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=1620|UniProtKB=P40227 P40227 CCT6A PTHR11353:SF54 CHAPERONIN T-COMPLEX PROTEIN 1 SUBUNIT ZETA metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;protein maturation#GO:0051604;protein folding#GO:0006457;biosynthetic process#GO:0009058 cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;chaperonin-containing T-complex#GO:0005832;protein folding chaperone complex#GO:0101031 chaperonin#PC00073 HUMAN|HGNC=9568|UniProtKB=Q06323 Q06323 PSME1 PTHR10660:SF5 PROTEASOME REGULATOR PA28 PROTEASOME ACTIVATOR COMPLEX SUBUNIT 1 peptidase regulator activity#GO:0061134;peptidase activator activity#GO:0016504;enzyme activator activity#GO:0008047;endopeptidase regulator activity#GO:0061135;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234 regulation of cell cycle phase transition#GO:1901987;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of cell cycle#GO:0051726;regulation of cell cycle G1/S phase transition#GO:1902806;regulation of G1/S transition of mitotic cell cycle#GO:2000045;regulation of mitotic cell cycle phase transition#GO:1901990;regulation of protein catabolic process#GO:0042176;regulation of primary metabolic process#GO:0080090;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of mitotic cell cycle#GO:0007346;regulation of proteasomal protein catabolic process#GO:0061136;biological regulation#GO:0065007;regulation of cell cycle process#GO:0010564;regulation of catabolic process#GO:0009894 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 HUMAN|HGNC=23293|UniProtKB=Q7Z5K2 Q7Z5K2 WAPL PTHR22100:SF13 WINGS APART-LIKE PROTEIN HOMOLOG WINGS APART-LIKE PROTEIN HOMOLOG HUMAN|HGNC=5100|UniProtKB=P31260 P31260 HOXA10 PTHR45874:SF1 HOMEOBOX PROTEIN ABDOMINAL-B HOMEOBOX PROTEIN HOX-A10 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 homeodomain transcription factor#PC00119 HUMAN|HGNC=22973|UniProtKB=A3KN83 A3KN83 SBNO1 PTHR12706:SF8 STRAWBERRY NOTCH-RELATED PROTEIN STRAWBERRY NOTCH HOMOLOG 1 protein binding#GO:0005515;DNA binding#GO:0003677;histone binding#GO:0042393;chromatin DNA binding#GO:0031490;chromatin binding#GO:0003682;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=12787|UniProtKB=P56706 P56706 WNT7B PTHR12027:SF73 WNT RELATED PROTEIN WNT-7B binding#GO:0005488;signaling receptor binding#GO:0005102;cytokine activity#GO:0005125;protein binding#GO:0005515;molecular function activator activity#GO:0140677;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;frizzled binding#GO:0005109;G protein-coupled receptor binding#GO:0001664;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546 cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;Wnt signaling pathway#GO:0016055;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;system development#GO:0048731;canonical Wnt signaling pathway#GO:0060070;cell communication#GO:0007154;anatomical structure development#GO:0048856;positive regulation of cellular process#GO:0048522;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;multicellular organismal process#GO:0032501;positive regulation of intracellular signal transduction#GO:1902533;developmental process#GO:0032502;regulation of response to stimulus#GO:0048583;neurogenesis#GO:0022008;positive regulation of MAPK cascade#GO:0043410;cellular developmental process#GO:0048869;regulation of biological process#GO:0050789;signaling#GO:0023052;cell differentiation#GO:0030154;response to stimulus#GO:0050896;generation of neurons#GO:0048699;regulation of signaling#GO:0023051;positive regulation of JNK cascade#GO:0046330;regulation of intracellular signal transduction#GO:1902531;animal gross anatomical part developmental process#GO:0160108;cell fate commitment#GO:0045165;positive regulation of signaling#GO:0023056;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;nervous system development#GO:0007399;regulation of MAPK cascade#GO:0043408;neuron differentiation#GO:0030182;cell surface receptor signaling pathway#GO:0007166;multicellular organism development#GO:0007275;regulation of JNK cascade#GO:0046328 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 Alzheimer disease-presenilin pathway#P00004>Wnt#P00142;Wnt signaling pathway#P00057>Wnt#P01444;Cadherin signaling pathway#P00012>Wnt#P00474;Angiogenesis#P00005>Wnt#P00206 HUMAN|HGNC=19873|UniProtKB=Q86SR1 Q86SR1 GALNT10 PTHR11675:SF41 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 10 polypeptide N-acetylgalactosaminyltransferase activity#GO:0004653;catalytic activity, acting on a protein#GO:0140096;UDP-glycosyltransferase activity#GO:0008194;acetylgalactosaminyltransferase activity#GO:0008376;glycosyltransferase activity#GO:0016757;hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;catalytic activity#GO:0003824 metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein O-linked glycosylation#GO:0006493;carbohydrate derivative metabolic process#GO:1901135;biosynthetic process#GO:0009058 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 glycosyltransferase#PC00111;transferase#PC00220 HUMAN|HGNC=93|UniProtKB=P24752 P24752 ACAT1 PTHR18919:SF156 ACETYL-COA C-ACYLTRANSFERASE ACETYL-COA ACETYLTRANSFERASE, MITOCHONDRIAL acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;acetyltransferase activity#GO:0016407;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746 sterol metabolic process#GO:0016125;steroid metabolic process#GO:0008202;primary metabolic process#GO:0044238;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;cellular process#GO:0009987 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 transferase#PC00220;acyltransferase#PC00042 CCKR signaling map#P06959>ACAT1#G06992;CCKR signaling map#P06959>ACAT1#G07285 HUMAN|HGNC=16211|UniProtKB=Q9UJQ7 Q9UJQ7 SCP2D1 PTHR10094:SF25 STEROL CARRIER PROTEIN 2 SCP-2 FAMILY PROTEIN SCP2 STEROL-BINDING DOMAIN-CONTAINING PROTEIN 1 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 transfer/carrier protein#PC00219 HUMAN|HGNC=6289|UniProtKB=Q86W47 Q86W47 KCNMB4 PTHR10258:SF3 CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA-4 molecular function regulator activity#GO:0098772;channel regulator activity#GO:0016247;potassium channel regulator activity#GO:0015459;transporter regulator activity#GO:0141108;ion channel regulator activity#GO:0099106 cellular process#GO:0009987;detection of stimulus#GO:0051606;biological regulation#GO:0065007;potassium ion transport#GO:0006813;response to chemical#GO:0042221;multicellular organismal process#GO:0032501;response to metal ion#GO:0010038;transport#GO:0006810;system process#GO:0003008;transmission of nerve impulse#GO:0019226;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;action potential#GO:0001508;detection of chemical stimulus#GO:0009593;metal ion transport#GO:0030001;response to stimulus#GO:0050896;nervous system process#GO:0050877;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;response to calcium ion#GO:0051592;cell communication#GO:0007154 transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797 voltage-gated ion channel#PC00241;ion channel#PC00133 HUMAN|HGNC=28905|UniProtKB=Q86U90 Q86U90 YRDC PTHR17490:SF16 SUA5 THREONYLCARBAMOYL-AMP SYNTHASE transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;transferase activity, transferring phosphorus-containing groups#GO:0016772;RNA binding#GO:0003723;tRNA binding#GO:0000049;nucleic acid binding#GO:0003676;binding#GO:0005488 tRNA modification#GO:0006400;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;regulation of biological quality#GO:0065008;RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;RNA processing#GO:0006396;biological regulation#GO:0065007;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=32469|UniProtKB=Q8NE65 Q8NE65 ZNF738 PTHR23232:SF67 KRAB DOMAIN C2H2 ZINC FINGER ZINC FINGER PROTEIN 738 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=33630|UniProtKB=C9JE40 C9JE40 PATL2 PTHR21551:SF3 TOPOISOMERASE II-ASSOCIATED PROTEIN PAT1 PROTEIN PAT1 HOMOLOG 2 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 mRNA metabolic process#GO:0016071;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of biological quality#GO:0065008;RNA catabolic process#GO:0006401;negative regulation of translation#GO:0017148;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;RNA destabilization#GO:0050779;cellular component biogenesis#GO:0044085;mRNA catabolic process#GO:0006402;organelle organization#GO:0006996;regulation of mRNA metabolic process#GO:1903311;cellular component organization or biogenesis#GO:0071840;macromolecule catabolic process#GO:0009057;mRNA destabilization#GO:0061157;positive regulation of RNA metabolic process#GO:0051254;negative regulation of protein metabolic process#GO:0051248;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;P-body assembly#GO:0033962;primary metabolic process#GO:0044238;regulation of RNA metabolic process#GO:0051252;RNA decapping#GO:0110154;regulation of RNA stability#GO:0043487;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;nucleic acid catabolic process#GO:0141188;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of catabolic process#GO:0009894;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;positive regulation of catabolic process#GO:0009896;macromolecule metabolic process#GO:0043170;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;regulation of mRNA stability#GO:0043488;negative regulation of metabolic process#GO:0009892;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;membraneless organelle assembly#GO:0140694;regulation of mRNA catabolic process#GO:0061013;RNA metabolic process#GO:0016070;positive regulation of metabolic process#GO:0009893;cellular component assembly#GO:0022607;regulation of protein metabolic process#GO:0051246;negative regulation of macromolecule biosynthetic process#GO:0010558;positive regulation of mRNA metabolic process#GO:1903313;metabolic process#GO:0008152;catabolic process#GO:0009056;positive regulation of mRNA catabolic process#GO:0061014;nucleic acid metabolic process#GO:0090304;organelle assembly#GO:0070925;nucleobase-containing compound metabolic process#GO:0006139;regulation of macromolecule biosynthetic process#GO:0010556;nucleobase-containing compound catabolic process#GO:0034655;regulation of translation#GO:0006417;regulation of gene expression#GO:0010468;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288 nucleus#GO:0005634;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;organelle#GO:0043226;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;P-body#GO:0000932;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 RNA metabolism protein#PC00031;RNA processing factor#PC00147 HUMAN|HGNC=634|UniProtKB=P41181 P41181 AQP2 PTHR19139:SF45 AQUAPORIN TRANSPORTER AQUAPORIN-2 channel activity#GO:0015267;water transmembrane transporter activity#GO:0005372;water channel activity#GO:0015250;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803 transport#GO:0006810;establishment of localization#GO:0051234;water transport#GO:0006833;localization#GO:0051179;fluid transport#GO:0042044 plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;apical plasma membrane#GO:0016324;membrane#GO:0016020;apical part of cell#GO:0045177;cell periphery#GO:0071944 transporter#PC00227 HUMAN|HGNC=16385|UniProtKB=Q96P11 Q96P11 NSUN5 PTHR22807:SF4 NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING 28S RRNA (CYTOSINE-C(5))-METHYLTRANSFERASE rRNA methyltransferase activity#GO:0008649;catalytic activity, acting on RNA#GO:0140098;RNA methyltransferase activity#GO:0008173;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on a rRNA#GO:0140102;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757 biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;post-transcriptional regulation of gene expression#GO:0010608;rRNA metabolic process#GO:0016072;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;positive regulation of biosynthetic process#GO:0009891;RNA methylation#GO:0001510;macromolecule modification#GO:0043412;positive regulation of translation#GO:0045727;rRNA processing#GO:0006364;positive regulation of macromolecule metabolic process#GO:0010604;gene expression#GO:0010467;RNA processing#GO:0006396;cellular component biogenesis#GO:0044085;regulation of protein metabolic process#GO:0051246;positive regulation of biological process#GO:0048518;rRNA base methylation#GO:0070475;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;rRNA methylation#GO:0031167;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;ribonucleoprotein complex biogenesis#GO:0022613;regulation of biological process#GO:0050789;rRNA modification#GO:0000154;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;RNA metabolic process#GO:0016070;methylation#GO:0032259;ribosome biogenesis#GO:0042254;macromolecule methylation#GO:0043414;nucleic acid biosynthetic process#GO:0141187;positive regulation of protein metabolic process#GO:0051247;RNA modification#GO:0009451 intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730 RNA metabolism protein#PC00031;RNA methyltransferase#PC00033 HUMAN|HGNC=37247|UniProtKB=Q96FH0 Q96FH0 BORCS8 PTHR21146:SF3 MEF2B PROTEIN BLOC-1-RELATED COMPLEX SUBUNIT 8 intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991 p38 MAPK pathway#P05918>MEF#P06023 HUMAN|HGNC=3222|UniProtKB=O43921 O43921 EFNA2 PTHR11304:SF4 EPHRIN EPHRIN-A2 protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 cellular developmental process#GO:0048869;neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;hemopoiesis#GO:0030097;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;axon development#GO:0061564;axon guidance#GO:0007411;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;osteoclast differentiation#GO:0030316;system development#GO:0048731;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of cellular process#GO:0050794;ephrin receptor signaling pathway#GO:0048013;cellular response to stimulus#GO:0051716;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cell projection morphogenesis#GO:0048858;neuron differentiation#GO:0030182;cell surface receptor signaling pathway#GO:0007166;plasma membrane bounded cell projection morphogenesis#GO:0120039;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;neuron projection development#GO:0031175;signal transduction#GO:0007165;cellular process#GO:0009987;neuron development#GO:0048666;axonogenesis#GO:0007409;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;cell differentiation#GO:0030154;response to stimulus#GO:0050896;cell projection organization#GO:0030030;cell morphogenesis#GO:0000902;myeloid cell differentiation#GO:0030099;bone remodeling#GO:0046849;signaling#GO:0023052;cell development#GO:0048468;tissue remodeling#GO:0048771;cellular component organization#GO:0016043;leukocyte differentiation#GO:0002521;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 intercellular signal molecule#PC00207;membrane-bound signaling molecule#PC00152 HUMAN|HGNC=17195|UniProtKB=Q8NEB7 Q8NEB7 ACRBP PTHR21362:SF1 ACROSIN-BINDING PROTEIN ACROSIN-BINDING PROTEIN anatomical structure development#GO:0048856;multicellular organismal reproductive process#GO:0048609;cellular component assembly involved in morphogenesis#GO:0010927;spermatid differentiation#GO:0048515;organelle assembly#GO:0070925;acrosome assembly#GO:0001675;spermatid development#GO:0007286;sexual reproduction#GO:0019953;gamete generation#GO:0007276;cell differentiation#GO:0030154;cell development#GO:0048468;reproductive process#GO:0022414;cellular process involved in reproduction in multicellular organism#GO:0022412;developmental process involved in reproduction#GO:0003006;cellular component organization#GO:0016043;germ cell development#GO:0007281;anatomical structure morphogenesis#GO:0009653;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;vesicle organization#GO:0016050;anatomical structure formation involved in morphogenesis#GO:0048646;cellular anatomical entity morphogenesis#GO:0032989;spermatogenesis#GO:0007283;developmental process#GO:0032502;male gamete generation#GO:0048232;cellular component assembly#GO:0022607;endomembrane system organization#GO:0010256;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987 intracellular organelle#GO:0043229;acrosomal vesicle#GO:0001669;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;vesicle#GO:0031982;secretory vesicle#GO:0099503;intracellular vesicle#GO:0097708;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 HUMAN|HGNC=8170|UniProtKB=Q8NGC3 Q8NGC3 OR10G2 PTHR26453:SF88 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 10G2 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 nervous system process#GO:0050877;sensory perception#GO:0007600;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;system process#GO:0003008;detection of chemical stimulus#GO:0009593;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;response to stimulus#GO:0050896;response to chemical#GO:0042221 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=5271|UniProtKB=Q9NNZ3 Q9NNZ3 DNAJC4 PTHR44825:SF1 FAMILY NOT NAMED DNAJ HOMOLOG SUBFAMILY C MEMBER 4 HUMAN|HGNC=33941|UniProtKB=P0CK96 P0CK96 SLC35E2B PTHR11132:SF521 SOLUTE CARRIER FAMILY 35 SOLUTE CARRIER FAMILY 35 MEMBER E2A-RELATED secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;antiporter activity#GO:0015297;active transmembrane transporter activity#GO:0022804 transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;cellular process#GO:0009987;transport#GO:0006810 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 transporter#PC00227;secondary carrier transporter#PC00258 HUMAN|HGNC=23176|UniProtKB=Q6H9L7 Q6H9L7 ISM2 PTHR10239:SF28 ISTHMIN-2 ISTHMIN-2 HUMAN|HGNC=32036|UniProtKB=A8MXV4 A8MXV4 NUDT19 PTHR12318:SF0 TESTOSTERONE-REGULATED PROTEIN RP2 ACYL-COENZYME A DIPHOSPHATASE NUDT19 HUMAN|HGNC=3059|UniProtKB=Q99075 Q99075 HBEGF PTHR10740:SF4 TRANSFORMING GROWTH FACTOR ALPHA PROHEPARIN-BINDING EGF-LIKE GROWTH FACTOR protein binding#GO:0005515;molecular function activator activity#GO:0140677;signaling receptor binding#GO:0005102;binding#GO:0005488;glycosaminoglycan binding#GO:0005539;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;carbohydrate derivative binding#GO:0097367;growth factor activity#GO:0008083;growth factor receptor binding#GO:0070851;heparin binding#GO:0008201 regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;signaling#GO:0023052;regulation of cell cycle#GO:0051726;positive regulation of cell population proliferation#GO:0008284;cellular response to stimulus#GO:0051716;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;positive regulation of cell cycle process#GO:0090068;positive regulation of organelle organization#GO:0010638;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of cell population proliferation#GO:0042127;cell communication#GO:0007154;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of cellular component organization#GO:0051130;epidermal growth factor receptor signaling pathway#GO:0007173;regulation of nuclear division#GO:0051783;positive regulation of cell cycle#GO:0045787;regulation of cell cycle process#GO:0010564;biological regulation#GO:0065007;regulation of mitotic cell cycle#GO:0007346;cellular process#GO:0009987;ERBB signaling pathway#GO:0038127;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of cellular process#GO:0048522;regulation of mitotic nuclear division#GO:0007088;cell surface receptor signaling pathway#GO:0007166;positive regulation of mitotic nuclear division#GO:0045840 cell periphery#GO:0071944;extracellular region#GO:0005576;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 growth factor#PC00112 CCKR signaling map#P06959>HBEGF#P07025;CCKR signaling map#P06959>HBEGF#G07261;CCKR signaling map#P06959>HBEGF#G06968;EGF receptor signaling pathway#P00018>EGF#P00549;CCKR signaling map#P06959>Pro HBEGF#P07182 HUMAN|HGNC=21403|UniProtKB=Q5TEZ5 Q5TEZ5 C6orf163 PTHR34645:SF1 SIMILAR TO HYPOTHETICAL PROTEIN SIMILAR TO HUMAN CHROMOSOME 6 OPEN READING FRAME 163 HUMAN|HGNC=20298|UniProtKB=Q8IXQ4 Q8IXQ4 GPALPP1 PTHR46370:SF1 GPALPP MOTIFS-CONTAINING PROTEIN 1 GPALPP MOTIFS-CONTAINING PROTEIN 1 HUMAN|HGNC=8040|UniProtKB=O95665 O95665 NTSR2 PTHR24243:SF10 G-PROTEIN COUPLED RECEPTOR NEUROTENSIN RECEPTOR TYPE 2 transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;neuropeptide receptor activity#GO:0008188;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;molecular transducer activity#GO:0060089 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;neuropeptide signaling pathway#GO:0007218;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HUMAN|HGNC=15632|UniProtKB=Q9NR97 Q9NR97 TLR8 PTHR47410:SF1 TOLL-LIKE RECEPTOR 7-RELATED TOLL-LIKE RECEPTOR 8 molecular transducer activity#GO:0060089;pattern recognition receptor activity#GO:0038187;signaling receptor activity#GO:0038023 regulation of innate immune response#GO:0045088;regulation of biosynthetic process#GO:0009889;positive regulation of response to biotic stimulus#GO:0002833;positive regulation of gene expression#GO:0010628;response to external stimulus#GO:0009605;defense response#GO:0006952;pattern recognition receptor signaling pathway#GO:0002221;regulation of gene expression#GO:0010468;regulation of response to stress#GO:0080134;positive regulation of immune response#GO:0050778;positive regulation of defense response#GO:0031349;regulation of response to stimulus#GO:0048583;positive regulation of response to stimulus#GO:0048584;canonical NF-kappaB signal transduction#GO:0007249;biological regulation#GO:0065007;response to other organism#GO:0051707;activation of innate immune response#GO:0002218;regulation of cytokine production#GO:0001817;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;positive regulation of innate immune response#GO:0045089;positive regulation of biosynthetic process#GO:0009891;cell communication#GO:0007154;response to virus#GO:0009615;intracellular signal transduction#GO:0035556;regulation of immune response#GO:0050776;regulation of defense response#GO:0031347;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;positive regulation of cytokine production#GO:0001819;response to external biotic stimulus#GO:0043207;regulation of response to biotic stimulus#GO:0002831;innate immune response-activating signaling pathway#GO:0002758;cellular response to stimulus#GO:0051716;immune response-activating signaling pathway#GO:0002757;positive regulation of response to external stimulus#GO:0032103;positive regulation of macromolecule metabolic process#GO:0010604;regulation of response to external stimulus#GO:0032101;regulation of multicellular organismal process#GO:0051239;intracellular signaling cassette#GO:0141124;response to biotic stimulus#GO:0009607;positive regulation of immune system process#GO:0002684;response to stress#GO:0006950;activation of immune response#GO:0002253;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;immune system process#GO:0002376;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052;toll-like receptor signaling pathway#GO:0002224;defense response to virus#GO:0051607;regulation of biological process#GO:0050789;positive regulation of multicellular organismal process#GO:0051240;immune response-regulating signaling pathway#GO:0002764 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 Toll receptor signaling pathway#P00054>TLR#P01346 HUMAN|HGNC=30884|UniProtKB=Q8IWB9 Q8IWB9 TEX2 PTHR13466:SF2 TEX2 PROTEIN-RELATED TESTIS-EXPRESSED PROTEIN 2 binding#GO:0005488;lipid binding#GO:0008289 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 HUMAN|HGNC=25475|UniProtKB=Q9NWD9 Q9NWD9 BEX4 PTHR13987:SF3 PROTEIN BEX4 PROTEIN BEX4 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 HUMAN|HGNC=55919|UniProtKB=A0A1W2PPK0 A0A1W2PPK0 CPHXL2 PTHR24341:SF8 HOMEOBOX PROTEIN ENGRAILED CYTOPLASMIC POLYADENYLATED HOMEOBOX-LIKE PROTEIN 2 cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;cellular process#GO:0009987;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;nervous system development#GO:0007399;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;developmental process#GO:0032502;neuron differentiation#GO:0030182;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119 HUMAN|HGNC=18885|UniProtKB=P59535 P59535 TAS2R40 PTHR11394:SF47 TASTE RECEPTOR TYPE 2 TASTE RECEPTOR TYPE 2 MEMBER 40 bitter taste receptor activity#GO:0033038;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;taste receptor activity#GO:0008527;transmembrane signaling receptor activity#GO:0004888 system process#GO:0003008;detection of chemical stimulus involved in sensory perception of bitter taste#GO:0001580;nervous system process#GO:0050877;detection of chemical stimulus involved in sensory perception of taste#GO:0050912;sensory perception#GO:0007600;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of taste#GO:0050909;multicellular organismal process#GO:0032501;response to chemical#GO:0042221;response to stimulus#GO:0050896;detection of chemical stimulus#GO:0009593;sensory perception of bitter taste#GO:0050913;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606 cellular anatomical structure#GO:0110165;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=5953|UniProtKB=O95976 O95976 IGSF6 PTHR15297:SF2 IMMUNOGLOBULIN SUPERFAMILY MEMBER 6 IMMUNOGLOBULIN SUPERFAMILY MEMBER 6 immunoglobulin#PC00123 HUMAN|HGNC=13923|UniProtKB=O15213 O15213 WDR46 PTHR14085:SF3 WD-REPEAT PROTEIN BING4 WD REPEAT-CONTAINING PROTEIN 46 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;ribonucleoprotein complex biogenesis#GO:0022613;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;biosynthetic process#GO:0009058;maturation of SSU-rRNA#GO:0030490;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467;ribosomal small subunit biogenesis#GO:0042274;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840 nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;small-subunit processome#GO:0032040;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;preribosome#GO:0030684;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=37225|UniProtKB=A8MZA4 A8MZA4 GOLGA6L6 PTHR23143:SF31 TRICHOHYALIN-RELATED GOLGIN SUBFAMILY A MEMBER 6-LIKE PROTEIN 1-RELATED actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=37321|UniProtKB=A0A1B0GVH4 A0A1B0GVH4 PRSS51 PTHR24253:SF132 TRANSMEMBRANE PROTEASE SERINE SERINE PROTEASE-LIKE PROTEIN 51 serine-type peptidase activity#GO:0008236;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;serine hydrolase activity#GO:0017171 protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604;metabolic process#GO:0008152;proteolysis#GO:0006508;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;protease#PC00190;serine protease#PC00203 HUMAN|Gene=HPF1L_HUMAN|UniProtKB=A8MVJ9 A8MVJ9 PTHR13386:SF3 HISTONE PARYLATION FACTOR 1 HISTONE PARYLATION FACTOR 1-LIKE-RELATED protein binding#GO:0005515;histone binding#GO:0042393;carbohydrate derivative binding#GO:0097367;binding#GO:0005488 double-strand break repair#GO:0006302;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;nucleobase-containing compound metabolic process#GO:0006139;chromatin organization#GO:0006325;cellular process#GO:0009987;response to stress#GO:0006950;cellular response to stress#GO:0033554;chromatin remodeling#GO:0006338;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 histone modifying enzyme#PC00261 HUMAN|HGNC=33227|UniProtKB=B3SHH9 B3SHH9 TMEM114 PTHR20516:SF2 TRANSMEMBRANE PROTEIN 114/235 FAMILY MEMBER TRANSMEMBRANE PROTEIN 114 plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;apical plasma membrane#GO:0016324;membrane#GO:0016020;apical part of cell#GO:0045177;cell periphery#GO:0071944 HUMAN|HGNC=177|UniProtKB=Q03154 Q03154 ACY1 PTHR45892:SF1 AMINOACYLASE-1 AMINOACYLASE-1 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;catalytic activity#GO:0003824;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity#GO:0016787 HUMAN|HGNC=2960|UniProtKB=O00115 O00115 DNASE2 PTHR10858:SF9 DEOXYRIBONUCLEASE II DEOXYRIBONUCLEASE-2-ALPHA hydrolase activity#GO:0016787;DNA endonuclease activity#GO:0004520;nuclease activity#GO:0004518;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity, acting on ester bonds#GO:0016788;DNA nuclease activity#GO:0004536;catalytic activity, acting on DNA#GO:0140097;endonuclease activity#GO:0004519 apoptotic DNA fragmentation#GO:0006309;nucleobase-containing compound metabolic process#GO:0006139;nucleic acid catabolic process#GO:0141188;cellular process#GO:0009987;nucleobase-containing compound catabolic process#GO:0034655;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;DNA metabolic process#GO:0006259;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;catabolic process#GO:0009056;apoptotic process#GO:0006915;cell death#GO:0008219;execution phase of apoptosis#GO:0097194;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;programmed cell death#GO:0012501;cellular component organization#GO:0016043;cellular component disassembly#GO:0022411;DNA catabolic process#GO:0006308 endodeoxyribonuclease#PC00093 HUMAN|HGNC=20728|UniProtKB=Q9Y2E8 Q9Y2E8 SLC9A8 PTHR10110:SF191 SODIUM/HYDROGEN EXCHANGER SODIUM_HYDROGEN EXCHANGER 8 potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075;metal cation:proton antiporter activity#GO:0051139;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;proton transmembrane transporter activity#GO:0015078;antiporter activity#GO:0015297;secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;regulation of pH#GO:0006885;regulation of intracellular pH#GO:0051453;import across plasma membrane#GO:0098739;inorganic ion import across plasma membrane#GO:0099587;homeostatic process#GO:0042592;metal ion transport#GO:0030001;intracellular monoatomic ion homeostasis#GO:0006873;sodium ion transport#GO:0006814;establishment of localization#GO:0051234;import into cell#GO:0098657;inorganic cation import across plasma membrane#GO:0098659;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;intracellular monoatomic cation homeostasis#GO:0030003;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;biological regulation#GO:0065007;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725 cell periphery#GO:0071944;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;plasma membrane#GO:0005886;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;endomembrane system#GO:0012505;trans-Golgi network membrane#GO:0032588;Golgi apparatus#GO:0005794;organelle membrane#GO:0031090;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622 secondary carrier transporter#PC00258 HUMAN|HGNC=23625|UniProtKB=Q8N2Y8 Q8N2Y8 RUSC2 PTHR15591:SF14 RUN AND SH3 DOMAIN CONTAINING AP-4 COMPLEX ACCESSORY SUBUNIT RUSC2 intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410 HUMAN|HGNC=37162|UniProtKB=P0CJ72 P0CJ72 MTRNR2L5 PTHR33895:SF4 HUMANIN-LIKE 4 HUMANIN-LIKE 5 signaling receptor inhibitor activity#GO:0030547;molecular function inhibitor activity#GO:0140678;molecular function regulator activity#GO:0098772;signaling receptor regulator activity#GO:0030545 negative regulation of cellular process#GO:0048523;regulation of apoptotic process#GO:0042981;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of programmed cell death#GO:0043069;negative regulation of apoptotic process#GO:0043066;regulation of cellular process#GO:0050794;biological regulation#GO:0065007 HUMAN|HGNC=32537|UniProtKB=Q58FF8 Q58FF8 HSP90AB2P PTHR11528:SF78 HEAT SHOCK PROTEIN 90 FAMILY MEMBER HEAT SHOCK PROTEIN HSP 90-BETA 2-RELATED ATP binding#GO:0005524;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;nucleoside phosphate binding#GO:1901265;ATP-dependent activity#GO:0140657;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;hydrolase activity, acting on acid anhydrides#GO:0016817;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167;hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleotide binding#GO:0000166 regulation of protein stability#GO:0031647;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;response to heat#GO:0009408;cellular response to heat#GO:0034605;response to stress#GO:0006950;biosynthetic process#GO:0009058;biological regulation#GO:0065007;response to temperature stimulus#GO:0009266;protein maturation#GO:0051604;gene expression#GO:0010467;metabolic process#GO:0008152;protein stabilization#GO:0050821;macromolecule metabolic process#GO:0043170;cellular response to stimulus#GO:0051716;response to abiotic stimulus#GO:0009628;primary metabolic process#GO:0044238;protein folding#GO:0006457;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;regulation of biological quality#GO:0065008;protein metabolic process#GO:0019538 intracellular anatomical structure#GO:0005622;cell periphery#GO:0071944;membrane#GO:0016020;cytosol#GO:0005829;cytoplasm#GO:0005737;perinuclear region of cytoplasm#GO:0048471;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 chaperone#PC00072;Hsp90 family chaperone#PC00028 HUMAN|HGNC=9776|UniProtKB=P57729 P57729 RAB38 PTHR24073:SF839 DRAB5-RELATED RAS-RELATED PROTEIN RAB-38 hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787 establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;developmental pigmentation#GO:0048066;cellular process#GO:0009987;macromolecule localization#GO:0033036;cellular pigmentation#GO:0033059;developmental maturation#GO:0021700;developmental process#GO:0032502;transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;response to external stimulus#GO:0009605;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;cell differentiation#GO:0030154;pigmentation#GO:0043473;protein transport#GO:0015031;localization#GO:0051179;cellular localization#GO:0051641 Golgi apparatus#GO:0005794;Golgi apparatus subcompartment#GO:0098791;endomembrane system#GO:0012505;trans-Golgi network#GO:0005802;melanosome#GO:0042470;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular vesicle#GO:0097708;vesicle#GO:0031982;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 G-protein#PC00020;small GTPase#PC00208 HUMAN|HGNC=14372|UniProtKB=Q96KG9 Q96KG9 SCYL1 PTHR12984:SF3 SCY1-RELATED S/T PROTEIN KINASE-LIKE N-TERMINAL KINASE-LIKE PROTEIN non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=29810|UniProtKB=Q99549 Q99549 MPHOSPH8 PTHR24166:SF47 ROLLING PEBBLES, ISOFORM B M-PHASE PHOSPHOPROTEIN 8 histone reader activity#GO:0140566;histone H3K9me2/3 reader activity#GO:0062072;molecular adaptor activity#GO:0060090;chromatin-protein adaptor activity#GO:0140463;chromatin binding#GO:0003682;protein-macromolecule adaptor activity#GO:0030674;histone H3 reader activity#GO:0140006;binding#GO:0005488 cellular component assembly#GO:0022607;chromatin organization#GO:0006325;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;heterochromatin organization#GO:0070828;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;epigenetic regulation of gene expression#GO:0040029;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;negative regulation of gene expression, epigenetic#GO:0045814;constitutive heterochromatin formation#GO:0140719;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;heterochromatin formation#GO:0031507 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;heterochromatin#GO:0000792;nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=21704|UniProtKB=Q9BV99 Q9BV99 LRRC61 PTHR15454:SF26 NISCHARIN RELATED LEUCINE-RICH REPEAT-CONTAINING PROTEIN 61 protein binding#GO:0005515;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631 plasma membrane bounded cell projection assembly#GO:0120031;protein-containing complex organization#GO:0043933;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;cell projection assembly#GO:0030031;cellular process#GO:0009987;outer dynein arm assembly#GO:0036158;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;axonemal dynein complex assembly#GO:0070286;microtubule bundle formation#GO:0001578;organelle assembly#GO:0070925;axoneme assembly#GO:0035082;cilium organization#GO:0044782;microtubule cytoskeleton organization#GO:0000226;protein-containing complex assembly#GO:0065003;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cell projection organization#GO:0030030 scaffold/adaptor protein#PC00226 HUMAN|HGNC=12210|UniProtKB=A0A5B7 A0A5B7 TRBV29-1 PTHR23268:SF117 T-CELL RECEPTOR BETA CHAIN T CELL RECEPTOR BETA VARIABLE 29-1 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=23534|UniProtKB=A6NHL2 A6NHL2 TUBAL3 PTHR11588:SF278 TUBULIN TUBULIN ALPHA CHAIN-LIKE 3 GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;guanyl nucleotide binding#GO:0019001;structural constituent of cytoskeleton#GO:0005200;binding#GO:0005488;nucleoside phosphate binding#GO:1901265;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;ribonucleotide binding#GO:0032553;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;carbohydrate derivative binding#GO:0097367;small molecule binding#GO:0036094;anion binding#GO:0043168;ion binding#GO:0043167;nucleotide binding#GO:0000166;structural molecule activity#GO:0005198 microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;cellular component organization#GO:0016043;cell cycle#GO:0007049;organelle organization#GO:0006996;cellular process#GO:0009987;mitotic cell cycle#GO:0000278;cytoskeleton organization#GO:0007010 organelle#GO:0043226;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630;microtubule#GO:0005874;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 cytoskeletal protein#PC00085;tubulin#PC00228 HUMAN|HGNC=11968|UniProtKB=Q9BT09 Q9BT09 CNPY3 PTHR15382:SF2 CTG4A-RELATED PROTEIN CANOPY HOMOLOG 3 signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515 HUMAN|HGNC=905|UniProtKB=P30530 P30530 AXL PTHR24416:SF323 TYROSINE-PROTEIN KINASE RECEPTOR TYROSINE-PROTEIN KINASE RECEPTOR UFO phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein tyrosine kinase activity#GO:0004714;molecular transducer activity#GO:0060089;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888;catalytic activity, acting on a protein#GO:0140096;signaling receptor activity#GO:0038023;transmembrane receptor protein kinase activity#GO:0019199;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 response to wounding#GO:0009611;cell migration#GO:0016477;negative regulation of apoptotic process#GO:0043066;regulation of signal transduction#GO:0009966;hemopoiesis#GO:0030097;phagocytosis#GO:0006909;positive regulation of intracellular signal transduction#GO:1902533;developmental process#GO:0032502;cellular developmental process#GO:0048869;establishment of localization#GO:0051234;platelet activation#GO:0030168;leukocyte activation#GO:0045321;positive regulation of cell communication#GO:0010647;cell activation#GO:0001775;lymphocyte differentiation#GO:0030098;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;localization#GO:0051179;regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051896;system development#GO:0048731;response to stress#GO:0006950;coagulation#GO:0050817;regulation of apoptotic process#GO:0042981;natural killer cell activation#GO:0030101;cell surface receptor signaling pathway#GO:0007166;import into cell#GO:0098657;leukocyte differentiation#GO:0002521;regulation of programmed cell death#GO:0043067;mononuclear cell differentiation#GO:1903131;regulation of body fluid levels#GO:0050878;cell differentiation#GO:0030154;signaling#GO:0023052;regulation of intracellular signal transduction#GO:1902531;positive regulation of signaling#GO:0023056;positive regulation of cellular process#GO:0048522;multicellular organismal process#GO:0032501;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;transport#GO:0006810;regulation of response to stimulus#GO:0048583;blood coagulation#GO:0007596;hemostasis#GO:0007599;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;cell motility#GO:0048870;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;anatomical structure development#GO:0048856;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;negative regulation of programmed cell death#GO:0043069;lymphocyte activation#GO:0046649;nervous system development#GO:0007399;multicellular organism development#GO:0007275;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;endocytosis#GO:0006897;response to stimulus#GO:0050896;positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051897;cell development#GO:0048468;animal gross anatomical part developmental process#GO:0160108;immune system process#GO:0002376;regulation of signaling#GO:0023051;wound healing#GO:0042060;regulation of biological quality#GO:0065008 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;signaling receptor complex#GO:0043235;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=2385|UniProtKB=Q49AN0 Q49AN0 CRY2 PTHR11455:SF15 CRYPTOCHROME CRYPTOCHROME-2 lyase activity#GO:0016829;binding#GO:0005488;flavin adenine dinucleotide binding#GO:0050660;nucleoside phosphate binding#GO:1901265;catalytic activity, acting on DNA#GO:0140097;heterocyclic compound binding#GO:1901363;carbon-carbon lyase activity#GO:0016830;DNA binding#GO:0003677;anion binding#GO:0043168;small molecule binding#GO:0036094;nucleic acid binding#GO:0003676;deoxyribodipyrimidine photo-lyase activity#GO:0003904;ion binding#GO:0043167;nucleotide binding#GO:0000166;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640 negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of metabolic process#GO:0009892;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;circadian regulation of gene expression#GO:0032922;response to abiotic stimulus#GO:0009628;negative regulation of biological process#GO:0048519;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;circadian rhythm#GO:0007623;negative regulation of DNA-templated transcription#GO:0045892;rhythmic process#GO:0048511;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;response to radiation#GO:0009314;negative regulation of macromolecule metabolic process#GO:0010605;regulation of circadian rhythm#GO:0042752;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;response to external stimulus#GO:0009605;regulation of biosynthetic process#GO:0009889;photoperiodism#GO:0009648;negative regulation of cellular process#GO:0048523;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;response to light stimulus#GO:0009416;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355 nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 DNA photolyase#PC00014 Circadian clock system#P00015>Cry#P00505;Circadian clock system#P00015>cry#G01501;Circadian clock system#P00015>cry#G01497 HUMAN|HGNC=1381|UniProtKB=P43166 P43166 CA7 PTHR18952:SF124 CARBONIC ANHYDRASE CARBONIC ANHYDRASE 7 catalytic activity#GO:0003824;lyase activity#GO:0016829;carbon-oxygen lyase activity#GO:0016835;hydro-lyase activity#GO:0016836 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 dehydratase#PC00091;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=24714|UniProtKB=Q8IWZ3 Q8IWZ3 ANKHD1 PTHR23206:SF5 MASK PROTEIN ANKYRIN REPEAT AND KH DOMAIN-CONTAINING PROTEIN 1 response to external stimulus#GO:0009605;defense response#GO:0006952;innate immune response#GO:0045087;immune system process#GO:0002376;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to other organism#GO:0051707;response to stimulus#GO:0050896;defense response to other organism#GO:0098542;immune response#GO:0006955;defense response to symbiont#GO:0140546;response to biotic stimulus#GO:0009607;response to stress#GO:0006950 nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 defense/immunity protein#PC00090 HUMAN|HGNC=28279|UniProtKB=Q8WVP5 Q8WVP5 TNFAIP8L1 PTHR12757:SF2 TUMOR NECROSIS FACTOR INDUCED PROTEIN TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 8-LIKE PROTEIN 1 regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;negative regulation of TOR signaling#GO:0032007;regulation of cell communication#GO:0010646;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of TOR signaling#GO:0032006;negative regulation of response to stimulus#GO:0048585;negative regulation of signal transduction#GO:0009968;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=25441|UniProtKB=Q6YI46 Q6YI46 TMEM64 PTHR46593:SF1 TRANSMEMBRANE PROTEIN 64 TRANSMEMBRANE PROTEIN 64 regulation of tissue remodeling#GO:0034103;regulation of hemopoiesis#GO:1903706;regulation of cytosolic calcium ion concentration#GO:0051480;homeostatic process#GO:0042592;regulation of developmental process#GO:0050793;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of cell differentiation#GO:0045595;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;positive regulation of developmental process#GO:0051094;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;regulation of cell development#GO:0060284;positive regulation of cellular process#GO:0048522;positive regulation of myeloid cell differentiation#GO:0045639;regulation of bone remodeling#GO:0046850;biological regulation#GO:0065007;inorganic ion homeostasis#GO:0098771;regulation of bone resorption#GO:0045124;calcium ion homeostasis#GO:0055074;regulation of myeloid cell differentiation#GO:0045637;positive regulation of multicellular organismal process#GO:0051240;regulation of multicellular organismal development#GO:2000026;regulation of biological process#GO:0050789;intracellular monoatomic ion homeostasis#GO:0006873;chemical homeostasis#GO:0048878;positive regulation of cell differentiation#GO:0045597;intracellular calcium ion homeostasis#GO:0006874;positive regulation of biological process#GO:0048518;positive regulation of immune system process#GO:0002684;monoatomic ion homeostasis#GO:0050801;regulation of multicellular organismal process#GO:0051239;positive regulation of cell development#GO:0010720 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=28096|UniProtKB=Q5T7R7 Q5T7R7 C1orf185 PTHR37858:SF1 HYPOTHETICAL PROTEIN LOC689589 SIMILAR TO HUMAN CHROMOSOME 1 OPEN READING FRAME 185 HUMAN|HGNC=12768|UniProtKB=Q9H3P2 Q9H3P2 NELFA PTHR13328:SF7 NEGATIVE ELONGATION FACTOR A NELF-A NEGATIVE ELONGATION FACTOR A regulation of DNA-templated transcription elongation#GO:0032784;regulation of transcription elongation by RNA polymerase II#GO:0034243;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;transcription elongation factor complex#GO:0008023;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;protein-containing complex#GO:0032991;nucleoplasm#GO:0005654;organelle#GO:0043226;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233 HUMAN|HGNC=19305|UniProtKB=Q6NXT4 Q6NXT4 SLC30A6 PTHR46531:SF1 ZINC TRANSPORTER 6 ZINC TRANSPORTER 6 establishment of localization#GO:0051234;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;transport#GO:0006810;transition metal ion transport#GO:0000041;zinc ion transport#GO:0006829;metal ion transport#GO:0030001 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 transporter#PC00227 HUMAN|HGNC=25862|UniProtKB=Q9BSC4 Q9BSC4 NOL10 PTHR14927:SF0 NUCLEOLAR PROTEIN 10 NUCLEOLAR PROTEIN 10 ribosomal small subunit biogenesis#GO:0042274;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;RNA processing#GO:0006396;maturation of SSU-rRNA#GO:0030490;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462 intracellular organelle#GO:0043229;preribosome#GO:0030684;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;small-subunit processome#GO:0032040;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991 HUMAN|HGNC=12494|UniProtKB=Q13404 Q13404 UBE2V1 PTHR24068:SF323 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2 VARIANT 1 transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;ubiquitin conjugating enzyme activity#GO:0061631;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-like protein conjugating enzyme activity#GO:0061650;ubiquitin-protein transferase activity#GO:0004842 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;DNA replication#GO:0006260;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;protein modification by small protein conjugation or removal#GO:0070647;cellular response to stress#GO:0033554;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;response to stress#GO:0006950;cellular process#GO:0009987;protein ubiquitination#GO:0016567;nucleobase-containing compound metabolic process#GO:0006139;post-translational protein modification#GO:0043687;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;DNA damage response#GO:0006974;DNA damage tolerance#GO:0006301;macromolecule metabolic process#GO:0043170;protein K63-linked ubiquitination#GO:0070534 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535 ubiquitin-protein ligase#PC00234 Toll receptor signaling pathway#P00054>Uev1A#P01376 HUMAN|HGNC=7853|UniProtKB=P56597 P56597 NME5 PTHR46161:SF1 NUCLEOSIDE DIPHOSPHATE KINASE NUCLEOSIDE DIPHOSPHATE KINASE 5 transferase#PC00220;kinase#PC00137;nucleotide kinase#PC00172 De novo purine biosynthesis#P02738>dADP kinase#P02907;De novo purine biosynthesis#P02738>GDP kinase#P02891 HUMAN|HGNC=12626|UniProtKB=Q9Y6I4 Q9Y6I4 USP3 PTHR21646:SF19 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 3 hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;cysteine-type deubiquitinase activity#GO:0004843 nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;response to stress#GO:0006950;cellular process#GO:0009987;regulation of protein stability#GO:0031647;macromolecule metabolic process#GO:0043170;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA damage response#GO:0006974;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;regulation of biological quality#GO:0065008;cellular response to stress#GO:0033554 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 cysteine protease#PC00081 HUMAN|HGNC=30259|UniProtKB=Q96GD0 Q96GD0 PDXP PTHR19288:SF94 4-NITROPHENYLPHOSPHATASE-RELATED CHRONOPHIN hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 hydrolase#PC00121;phosphatase#PC00181 HUMAN|HGNC=14495|UniProtKB=Q9Y399 Q9Y399 MRPS2 PTHR12534:SF0 30S RIBOSOMAL PROTEIN S2 PROKARYOTIC AND ORGANELLAR SMALL RIBOSOMAL SUBUNIT PROTEIN US2M structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 mitochondrion#GO:0005739;ribosome#GO:0005840;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;small ribosomal subunit#GO:0015935;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;membrane-bounded organelle#GO:0043227;organellar ribosome#GO:0000313;intracellular anatomical structure#GO:0005622;mitochondrial ribosome#GO:0005761;membrane-enclosed lumen#GO:0031974;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;membraneless organelle#GO:0043228;mitochondrial small ribosomal subunit#GO:0005763 ribosomal protein#PC00202 HUMAN|HGNC=16744|UniProtKB=Q9ULV3 Q9ULV3 CIZ1 PTHR15491:SF9 FAMILY NOT NAMED CIP1-INTERACTING ZINC FINGER PROTEIN regulation of DNA replication#GO:0006275;positive regulation of metabolic process#GO:0009893;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of DNA metabolic process#GO:0051054;regulation of DNA metabolic process#GO:0051052;regulation of DNA-templated DNA replication#GO:0090329;regulation of biological process#GO:0050789;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of DNA-templated DNA replication initiation#GO:0030174;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of DNA replication#GO:0045740;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=23249|UniProtKB=Q86VF5 Q86VF5 MOGAT3 PTHR12317:SF36 DIACYLGLYCEROL O-ACYLTRANSFERASE 2-ACYLGLYCEROL O-ACYLTRANSFERASE 3 acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824 neutral lipid metabolic process#GO:0006638;acylglycerol metabolic process#GO:0006639;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;triglyceride metabolic process#GO:0006641;lipid biosynthetic process#GO:0008610;glycerolipid metabolic process#GO:0046486;triglyceride biosynthetic process#GO:0019432;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017 organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 transferase#PC00220;acyltransferase#PC00042 HUMAN|HGNC=12474|UniProtKB=P51668 P51668 UBE2D1 PTHR24068:SF36 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2 D1 ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-like protein conjugating enzyme activity#GO:0061650;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin conjugating enzyme activity#GO:0061631 catabolic process#GO:0009056;modification-dependent protein catabolic process#GO:0019941;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein modification by small protein conjugation or removal#GO:0070647;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;cellular process#GO:0009987;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;protein K48-linked ubiquitination#GO:0070936 ubiquitin-protein ligase#PC00234 Ubiquitin proteasome pathway#P00060>E2#P01491 HUMAN|HGNC=16093|UniProtKB=Q8NDY6 Q8NDY6 BHLHE23 PTHR19290:SF53 BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED CLASS E BASIC HELIX-LOOP-HELIX PROTEIN 23 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987 developmental process#GO:0032502;sensory organ development#GO:0007423;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;axon development#GO:0061564;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;plasma membrane bounded cell projection organization#GO:0120036;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;multicellular organismal process#GO:0032501;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;neuron differentiation#GO:0030182;positive regulation of transcription by RNA polymerase II#GO:0045944;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;animal organ development#GO:0048513;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;neuron projection development#GO:0031175;nervous system development#GO:0007399;positive regulation of macromolecule metabolic process#GO:0010604;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;neuron development#GO:0048666;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;cell development#GO:0048468;regulation of transcription by RNA polymerase II#GO:0006357;cell projection organization#GO:0030030;cell differentiation#GO:0030154 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=14036|UniProtKB=Q8TCC3 Q8TCC3 MRPL30 PTHR15892:SF2 MITOCHONDRIAL RIBOSOMAL PROTEIN L30 LARGE RIBOSOMAL SUBUNIT PROTEIN UL30M structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 metabolic process#GO:0008152;translation#GO:0006412;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;biosynthetic process#GO:0009058 intracellular anatomical structure#GO:0005622;mitochondrial ribosome#GO:0005761;organellar ribosome#GO:0000313;membrane-bounded organelle#GO:0043227;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;mitochondrion#GO:0005739;organelle lumen#GO:0043233;membraneless organelle#GO:0043228;mitochondrial large ribosomal subunit#GO:0005762;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;membrane-enclosed lumen#GO:0031974 ribosomal protein#PC00202;translational protein#PC00263 HUMAN|HGNC=11439|UniProtKB=Q12846 Q12846 STX4 PTHR19957:SF97 SYNTAXIN SYNTAXIN-4 SNAP receptor activity#GO:0005484;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907;vesicle organization#GO:0016050;exocytosis#GO:0006887;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;membrane fusion#GO:0061025;macromolecule localization#GO:0033036;organelle organization#GO:0006996;organelle membrane fusion#GO:0090174;membrane organization#GO:0061024;vesicle-mediated transport#GO:0016192;organelle fusion#GO:0048284;protein transport#GO:0015031;secretion by cell#GO:0032940;secretion#GO:0046903;cellular localization#GO:0051641;localization#GO:0051179;cellular component organization#GO:0016043;vesicle fusion#GO:0006906;export from cell#GO:0140352 membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;protein-containing complex#GO:0032991;SNARE complex#GO:0031201;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622 SNARE protein#PC00034 Nicotinic acetylcholine receptor signaling pathway#P00044>SNARE Complex#P01091;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>SNARE Complex#P01079 HUMAN|HGNC=14631|UniProtKB=Q86TH1 Q86TH1 ADAMTSL2 PTHR13723:SF147 ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE ADAMTS-LIKE PROTEIN 2 metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 cellular component organization#GO:0016043;primary metabolic process#GO:0044238;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;extracellular matrix organization#GO:0030198;protein metabolic process#GO:0019538;external encapsulating structure organization#GO:0045229;proteolysis#GO:0006508;metabolic process#GO:0008152;extracellular structure organization#GO:0043062 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012 metalloprotease#PC00153 HUMAN|HGNC=25331|UniProtKB=Q8NDQ6 Q8NDQ6 ZNF540 PTHR24377:SF138 IP01015P-RELATED ZINC FINGER PROTEIN 540 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=29284|UniProtKB=Q9P265 Q9P265 DIP2B PTHR22754:SF38 DISCO-INTERACTING PROTEIN 2 DIP2 -RELATED DISCO-INTERACTING PROTEIN 2 HOMOLOG B catalytic activity#GO:0003824;ligase activity, forming carbon-sulfur bonds#GO:0016877;ligase activity#GO:0016874 regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of developmental process#GO:0050793;negative regulation of biological process#GO:0048519;negative regulation of multicellular organismal process#GO:0051241;cellular component organization#GO:0016043;regulation of neurogenesis#GO:0050767;negative regulation of cellular component organization#GO:0051129;regulation of cellular component size#GO:0032535;regulation of biological process#GO:0050789;regulation of growth#GO:0040008;regulation of multicellular organismal development#GO:2000026;regulation of nervous system development#GO:0051960;regulation of cell size#GO:0008361;regulation of biological quality#GO:0065008;regulation of cell growth#GO:0001558;biological regulation#GO:0065007;negative regulation of cell growth#GO:0030308;regulation of multicellular organismal process#GO:0051239;regulation of neuron projection development#GO:0010975;cellular process#GO:0009987;regulation of cell development#GO:0060284;cellular component organization or biogenesis#GO:0071840;regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of anatomical structure morphogenesis#GO:0022603;regulation of axonogenesis#GO:0050770;regulation of cell projection organization#GO:0031344;regulation of anatomical structure size#GO:0090066;negative regulation of cellular process#GO:0048523;regulation of cell differentiation#GO:0045595 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=8717|UniProtKB=Q9Y5F7 Q9Y5F7 PCDHGC4 PTHR24028:SF272 CADHERIN-87A PROTOCADHERIN GAMMA-C4 cellular process#GO:0009987;cell adhesion#GO:0007155 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 cell adhesion molecule#PC00069;cadherin#PC00057 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HUMAN|HGNC=17085|UniProtKB=Q9Y2D4 Q9Y2D4 EXOC6B PTHR12702:SF3 SEC15 EXOCYST COMPLEX COMPONENT 6B export from cell#GO:0140352;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;secretion by cell#GO:0032940;exocytosis#GO:0006887;localization#GO:0051179;secretion#GO:0046903;establishment of localization#GO:0051234;transport#GO:0006810 cell periphery#GO:0071944;cell cortex#GO:0005938;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;exocyst#GO:0000145;intracellular anatomical structure#GO:0005622;vesicle tethering complex#GO:0099023 membrane traffic protein#PC00150 HUMAN|HGNC=2484|UniProtKB=P33240 P33240 CSTF2 PTHR45735:SF6 CLEAVAGE STIMULATION FACTOR SUBUNIT 2 CLEAVAGE STIMULATION FACTOR SUBUNIT 2 binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723 mRNA cleavage and polyadenylation specificity factor complex#GO:0005847;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;protein-containing complex#GO:0032991;mRNA cleavage factor complex#GO:0005849;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 mRNA polyadenylation factor#PC00146;RNA processing factor#PC00147;RNA metabolism protein#PC00031 HUMAN|HGNC=7646|UniProtKB=P11245 P11245 NAT2 PTHR11786:SF6 N-HYDROXYARYLAMINE O-ACETYLTRANSFERASE ARYLAMINE N-ACETYLTRANSFERASE 2 N-acetyltransferase activity#GO:0008080;catalytic activity#GO:0003824;transferase activity#GO:0016740;acetyltransferase activity#GO:0016407;acyltransferase activity#GO:0016746;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 acetyltransferase#PC00038 HUMAN|HGNC=24746|UniProtKB=Q8N9V7 Q8N9V7 TOPAZ1 PTHR35671:SF1 PROTEIN TOPAZ1 PROTEIN TOPAZ1 multicellular organismal reproductive process#GO:0048609;spermatogenesis#GO:0007283;sexual reproduction#GO:0019953;developmental process#GO:0032502;reproductive process#GO:0022414;gamete generation#GO:0007276;male gamete generation#GO:0048232;cellular process#GO:0009987;cell division#GO:0051301;developmental process involved in reproduction#GO:0003006 HUMAN|HGNC=30635|UniProtKB=O94993 O94993 SOX30 PTHR47279:SF1 TRANSCRIPTION FACTOR SOX-30 TRANSCRIPTION FACTOR SOX-30 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HUMAN|HGNC=19083|UniProtKB=P61024 P61024 CKS1B PTHR23415:SF42 CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7 CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT 1 kinase activator activity#GO:0019209;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;protein serine/threonine kinase activator activity#GO:0043539;enzyme activator activity#GO:0008047;cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538;protein kinase activator activity#GO:0030295;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;protein kinase regulator activity#GO:0019887;cyclin-dependent protein kinase regulator activity#GO:0019914 cell cycle phase transition#GO:0044770;mitotic cell cycle#GO:0000278;mitotic cell cycle process#GO:1903047;cell cycle#GO:0007049;mitotic cell cycle phase transition#GO:0044772;cellular process#GO:0009987;cell cycle process#GO:0022402 cellular anatomical structure#GO:0110165;organelle#GO:0043226;SCF ubiquitin ligase complex#GO:0019005;intracellular membrane-bounded organelle#GO:0043231;cullin-RING ubiquitin ligase complex#GO:0031461;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ubiquitin ligase complex#GO:0000151;intracellular anatomical structure#GO:0005622;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;protein-containing complex#GO:0032991;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;protein kinase complex#GO:1902911 scaffold/adaptor protein#PC00226 HUMAN|HGNC=4665|UniProtKB=Q8WUA4 Q8WUA4 GTF3C2 PTHR15052:SF2 RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR COMPLEX SUBUNIT GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 2 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;rDNA binding#GO:0000182;double-stranded DNA binding#GO:0003690 rRNA transcription#GO:0009303;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;transcription by RNA polymerase III#GO:0006383;transcription initiation at RNA polymerase III promoter#GO:0006384;DNA-templated transcription initiation#GO:0006352;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070 intracellular organelle#GO:0043229;transcription factor TFIIIC complex#GO:0000127;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;nucleus#GO:0005634;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=6232|UniProtKB=Q92953 Q92953 KCNB2 PTHR11537:SF134 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY B MEMBER 2 molecular function regulator activity#GO:0098772;channel regulator activity#GO:0016247;ion channel regulator activity#GO:0099106;potassium channel regulator activity#GO:0015459;transporter regulator activity#GO:0141108 monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;metal ion transport#GO:0030001;action potential#GO:0001508;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;transport#GO:0006810;monoatomic ion transmembrane transport#GO:0034220;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;biological regulation#GO:0065007;potassium ion transport#GO:0006813;cellular process#GO:0009987 plasma membrane protein complex#GO:0098797;cell body#GO:0044297;membrane protein complex#GO:0098796;plasma membrane bounded cell projection#GO:0120025;neuronal cell body#GO:0043025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;dendritic tree#GO:0097447;dendrite#GO:0030425;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;neuron projection#GO:0043005;membrane#GO:0016020;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;transporter complex#GO:1990351 voltage-gated ion channel#PC00241;ion channel#PC00133 HUMAN|HGNC=28508|UniProtKB=Q8NE22 Q8NE22 SETD9 PTHR33524:SF2 C5ORF35 SET DOMAIN-CONTAINING PROTEIN 9 HUMAN|HGNC=18523|UniProtKB=Q6VB84 Q6VB84 FOXD4L3 PTHR11829:SF420 FORKHEAD BOX PROTEIN FORKHEAD BOX PROTEIN D4-LIKE 3-RELATED sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;developmental process#GO:0032502;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 winged helix/forkhead transcription factor#PC00246;gene-specific transcriptional regulator#PC00264;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=28767|UniProtKB=Q587I9 Q587I9 SFT2D3 PTHR23137:SF36 VESICLE TRANSPORT PROTEIN-RELATED VESICLE TRANSPORT PROTEIN SFT2C HUMAN|HGNC=10348|UniProtKB=P61513 P61513 RPL37A PTHR48160:SF1 LARGE RIBOSOMAL SUBUNIT PROTEIN EL43 LARGE RIBOSOMAL SUBUNIT PROTEIN EL43 ribosome#GO:0005840;cytosolic large ribosomal subunit#GO:0022625;cytosolic ribosome#GO:0022626;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular organelle#GO:0043229;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 HUMAN|HGNC=8648|UniProtKB=Q15366 Q15366 PCBP2 PTHR10288:SF97 KH DOMAIN CONTAINING RNA BINDING PROTEIN POLY(RC)-BINDING PROTEIN 2 single-stranded DNA binding#GO:0003697;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;DNA binding#GO:0003677;RNA binding#GO:0003723 positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;positive regulation of RNA metabolic process#GO:0051254;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 RNA metabolism protein#PC00031 HUMAN|HGNC=23404|UniProtKB=Q9P2V4 Q9P2V4 LRIT1 PTHR45842:SF9 SYNAPTIC ADHESION-LIKE MOLECULE SALM LEUCINE-RICH REPEAT, IMMUNOGLOBULIN-LIKE DOMAIN AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 1 immunoglobulin superfamily cell adhesion molecule#PC00125;cell adhesion molecule#PC00069 HUMAN|HGNC=7595|UniProtKB=Q9UBC5 Q9UBC5 MYO1A PTHR13140:SF291 MYOSIN UNCONVENTIONAL MYOSIN-IA microfilament motor activity#GO:0000146;catalytic activity#GO:0003824;polypeptide conformation or assembly isomerase activity#GO:0120544;ATP-dependent activity#GO:0140657;macromolecular conformation isomerase activity#GO:0120543;cytoskeletal motor activity#GO:0003774;isomerase activity#GO:0016853 cellular process#GO:0009987;actin filament-based movement#GO:0030048;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;multicellular organismal process#GO:0032501;transport#GO:0006810;actin filament organization#GO:0007015;system process#GO:0003008;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;import into cell#GO:0098657;cellular component organization#GO:0016043;sensory perception of sound#GO:0007605;actin cytoskeleton organization#GO:0030036;endocytosis#GO:0006897;sensory perception#GO:0007600;sensory perception of mechanical stimulus#GO:0050954;actin filament-based process#GO:0030029;nervous system process#GO:0050877;supramolecular fiber organization#GO:0097435;localization#GO:0051179 microvillus#GO:0005902;actin-based cell projection#GO:0098858;actin cytoskeleton#GO:0015629;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;cluster of actin-based cell projections#GO:0098862;intracellular anatomical structure#GO:0005622;cell periphery#GO:0071944;brush border#GO:0005903;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;apical part of cell#GO:0045177;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228 actin binding motor protein#PC00040 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HUMAN|HGNC=7982|UniProtKB=Q92570 Q92570 NR4A3 PTHR24085:SF2 NUCLEAR HORMONE RECEPTOR NUCLEAR RECEPTOR SUBFAMILY 4 GROUP A MEMBER 3 sequence-specific DNA binding#GO:0043565;nuclear receptor binding#GO:0016922;protein binding#GO:0005515;transcription regulatory region nucleic acid binding#GO:0001067;RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629;DNA-binding transcription factor binding#GO:0140297;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;transcription factor binding#GO:0008134;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976 response to nitrogen compound#GO:1901698;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;response to oxygen-containing compound#GO:1901700;cellular response to chemical stimulus#GO:0070887;cellular response to peptide hormone stimulus#GO:0071375;cellular response to endogenous stimulus#GO:0071495;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cellular response to hormone stimulus#GO:0032870;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to endogenous stimulus#GO:0009719;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;response to peptide hormone#GO:0043434;response to chemical#GO:0042221;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular response to nitrogen compound#GO:1901699;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;response to hormone#GO:0009725;regulation of metabolic process#GO:0019222 organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;C4 zinc finger nuclear receptor#PC00169 HUMAN|HGNC=30954|UniProtKB=Q8IW36 Q8IW36 ZNF695 PTHR24384:SF119 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED ZINC FINGER PROTEIN 695 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 DNA-binding transcription factor#PC00218 HUMAN|HGNC=7944|UniProtKB=P20594 P20594 NPR2 PTHR11920:SF509 GUANYLYL CYCLASE ATRIAL NATRIURETIC PEPTIDE RECEPTOR 2 peptide receptor activity#GO:0001653;signaling receptor activity#GO:0038023;guanylate cyclase activity#GO:0004383;catalytic activity#GO:0003824;phosphorus-oxygen lyase activity#GO:0016849;cyclase activity#GO:0009975;lyase activity#GO:0016829;molecular transducer activity#GO:0060089 regulation of biological process#GO:0050789;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;phosphorus metabolic process#GO:0006793;signaling#GO:0023052;response to stimulus#GO:0050896;small molecule metabolic process#GO:0044281;cyclic nucleotide biosynthetic process#GO:0009190;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;ribonucleotide metabolic process#GO:0009259;nucleotide biosynthetic process#GO:0009165;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;signal transduction#GO:0007165;receptor guanylyl cyclase signaling pathway#GO:0007168;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;ribose phosphate biosynthetic process#GO:0046390;cyclic purine nucleotide metabolic process#GO:0052652;cell surface receptor signaling pathway#GO:0007166;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative biosynthetic process#GO:1901137;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;nucleoside phosphate metabolic process#GO:0006753;regulation of cellular process#GO:0050794;cell communication#GO:0007154;cGMP biosynthetic process#GO:0006182;enzyme-linked receptor protein signaling pathway#GO:0007167;organophosphate biosynthetic process#GO:0090407;carbohydrate derivative metabolic process#GO:1901135;cGMP metabolic process#GO:0046068;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;cyclic nucleotide metabolic process#GO:0009187;nucleoside phosphate biosynthetic process#GO:1901293 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 guanylate cyclase#PC00114;lyase#PC00144 Gonadotropin-releasing hormone receptor pathway#P06664>Npr2#P06796 HUMAN|HGNC=18363|UniProtKB=Q8IU54 Q8IU54 IFNL1 PTHR31943:SF14 INTERLEUKIN-28 AND 29 INTERFERON LAMBDA-1 signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;cytokine activity#GO:0005125;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018 immune system process#GO:0002376;response to external stimulus#GO:0009605;defense response#GO:0006952;response to virus#GO:0009615;innate immune response#GO:0045087;immune response#GO:0006955;defense response to symbiont#GO:0140546;defense response to virus#GO:0051607;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to other organism#GO:0051707;response to stimulus#GO:0050896;defense response to other organism#GO:0098542 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 cytokine#PC00083;interleukin superfamily#PC00128;intercellular signal molecule#PC00207 HUMAN|HGNC=23382|UniProtKB=Q96J77 Q96J77 TPD52L3 PTHR19307:SF5 TUMOR PROTEIN D52 TUMOR PROTEIN D55 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=2067|UniProtKB=O00151 O00151 PDLIM1 PTHR24214:SF5 PDZ AND LIM DOMAIN PROTEIN ZASP PDZ AND LIM DOMAIN PROTEIN 1 cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;binding#GO:0005488;protein binding#GO:0005515 multicellular organismal process#GO:0032501;heart development#GO:0007507;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular process#GO:0009987;animal organ development#GO:0048513;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;developmental process#GO:0032502;actin cytoskeleton organization#GO:0030036;muscle structure development#GO:0061061;circulatory system development#GO:0072359;cellular component organization#GO:0016043;anatomical structure development#GO:0048856;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;actin filament-based process#GO:0030029 actin cytoskeleton#GO:0015629;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;myofibril#GO:0030016;actin filament bundle#GO:0032432;contractile muscle fiber#GO:0043292;Z disc#GO:0030018;actomyosin#GO:0042641;cell-cell junction#GO:0005911;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;I band#GO:0031674;actin filament#GO:0005884;stress fiber#GO:0001725;cytoskeleton#GO:0005856;adherens junction#GO:0005912;sarcomere#GO:0030017;cell junction#GO:0030054;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|Ensembl=ENSG00000274042.2|UniProtKB=A0A0M3HER8 A0A0M3HER8 GOLGA6L10 PTHR23143:SF19 TRICHOHYALIN-RELATED GOLGIN A6 FAMILY LIKE 10-RELATED actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=9470|UniProtKB=O14669 O14669 PRRG2 PTHR24278:SF30 COAGULATION FACTOR TRANSMEMBRANE GAMMA-CARBOXYGLUTAMIC ACID PROTEIN 2 hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;serine-type peptidase activity#GO:0008236;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity#GO:0003824 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;extracellular region#GO:0005576 serine protease#PC00203 HUMAN|HGNC=7739|UniProtKB=P07196 P07196 NEFL PTHR45652:SF8 GLIAL FIBRILLARY ACIDIC PROTEIN NEUROFILAMENT LIGHT POLYPEPTIDE structural constituent of cytoskeleton#GO:0005200;structural constituent of synapse#GO:0098918;structural molecule activity#GO:0005198 intermediate filament cytoskeleton organization#GO:0045104;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;supramolecular fiber organization#GO:0097435;intermediate filament bundle assembly#GO:0045110;intermediate filament-based process#GO:0045103;intermediate filament organization#GO:0045109 cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;postsynapse#GO:0098794;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;axon#GO:0030424;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;neuron projection#GO:0043005;intermediate filament#GO:0005882;cell junction#GO:0030054;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856 intermediate filament#PC00129;cytoskeletal protein#PC00085 HUMAN|HGNC=21752|UniProtKB=Q9NRP4 Q9NRP4 SDHAF3 PTHR13137:SF6 DC11 ACN9 HOMOLOG SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 3, MITOCHONDRIAL cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;cellular component assembly#GO:0022607;mitochondrial respiratory chain complex assembly#GO:0033108;mitochondrion organization#GO:0007005;mitochondrial respiratory chain complex II assembly#GO:0034553;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=3581|UniProtKB=Q12830 Q12830 BPTF PTHR45975:SF2 NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF HUMAN|HGNC=31952|UniProtKB=A6NCF5 A6NCF5 KLHL33 PTHR45632:SF14 LD33804P KELCH-LIKE PROTEIN 33 scaffold/adaptor protein#PC00226 HUMAN|HGNC=32689|UniProtKB=P0C7P3 P0C7P3 SLFN14 PTHR12155:SF30 SCHLAFEN PROTEIN SLFN14 catalytic activity, acting on RNA#GO:0140098;RNA endonuclease activity#GO:0004521;endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;ribonucleoprotein complex binding#GO:0043021;protein-containing complex binding#GO:0044877;nuclease activity#GO:0004518;ribosome binding#GO:0043022;binding#GO:0005488 nucleobase-containing compound catabolic process#GO:0034655;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;nucleic acid catabolic process#GO:0141188;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;rRNA metabolic process#GO:0016072;negative regulation of cellular process#GO:0048523;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;RNA catabolic process#GO:0006401;RNA metabolic process#GO:0016070 endoribonuclease#PC00094 HUMAN|HGNC=21748|UniProtKB=Q6X4U4 Q6X4U4 SOSTDC1 PTHR14903:SF5 SCLEROSTIN-RELATED SCLEROSTIN DOMAIN-CONTAINING PROTEIN 1 protein binding#GO:0005515;cytokine binding#GO:0019955;binding#GO:0005488 negative regulation of BMP signaling pathway#GO:0030514;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;negative regulation of Wnt signaling pathway#GO:0030178;negative regulation of response to stimulus#GO:0048585;negative regulation of signal transduction#GO:0009968;regulation of cellular response to growth factor stimulus#GO:0090287;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of BMP signaling pathway#GO:0030510;negative regulation of cell communication#GO:0010648;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;regulation of cellular process#GO:0050794;regulation of Wnt signaling pathway#GO:0030111;regulation of cell communication#GO:0010646;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HUMAN|HGNC=29249|UniProtKB=Q6P3S6 Q6P3S6 FBXO42 PTHR46432:SF1 F-BOX ONLY PROTEIN 42 F-BOX ONLY PROTEIN 42 ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;cullin-RING ubiquitin ligase complex#GO:0031461;SCF ubiquitin ligase complex#GO:0019005;intracellular protein-containing complex#GO:0140535;catalytic complex#GO:1902494;transferase complex#GO:1990234 HUMAN|HGNC=16084|UniProtKB=Q7Z4I7 Q7Z4I7 LIMS2 PTHR24210:SF10 LIM DOMAIN-CONTAINING PROTEIN LIM AND SENESCENT CELL ANTIGEN-LIKE-CONTAINING DOMAIN PROTEIN 2 regulation of signaling#GO:0023051;cell adhesion#GO:0007155;positive regulation of signaling#GO:0023056;cellular component organization#GO:0016043;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789;positive regulation of cell communication#GO:0010647;cell junction organization#GO:0034330;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of response to stimulus#GO:0048583;cell-cell junction organization#GO:0045216;cellular component organization or biogenesis#GO:0071840;cell-cell adhesion#GO:0098609;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966 cell-cell junction#GO:0005911;focal adhesion#GO:0005925;cell-substrate junction#GO:0030055;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;cell junction#GO:0030054 cell junction protein#PC00070 Integrin signalling pathway#P00034>PINCH#P00921 HUMAN|HGNC=10899|UniProtKB=P63208 P63208 SKP1 PTHR11165:SF189 SKP1 S-PHASE KINASE-ASSOCIATED PROTEIN 1 binding#GO:0005488;protein binding#GO:0005515 proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;macromolecule catabolic process#GO:0009057 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=11778|UniProtKB=P21980 P21980 TGM2 PTHR11590:SF6 PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE 2 catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746 transferase#PC00220 HUMAN|HGNC=1355|UniProtKB=Q9Y236 Q9Y236 OSGIN2 PTHR15192:SF4 PROTEIN CBG05349 OXIDATIVE STRESS-INDUCED GROWTH INHIBITOR 2 receptor ligand activity#GO:0048018;growth factor activity#GO:0008083;signaling receptor regulator activity#GO:0030545;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772 regulation of growth#GO:0040008;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of cell growth#GO:0030308;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of cell growth#GO:0001558;negative regulation of cellular process#GO:0048523 HUMAN|HGNC=17145|UniProtKB=O95295 O95295 SNAPIN PTHR31305:SF3 SNARE-ASSOCIATED PROTEIN SNAPIN SNARE-ASSOCIATED PROTEIN SNAPIN SNARE binding#GO:0000149;binding#GO:0005488;protein binding#GO:0005515 homeostatic process#GO:0042592;anterograde trans-synaptic signaling#GO:0098916;signal release from synapse#GO:0099643;chemical synaptic transmission#GO:0007268;localization#GO:0051179;cell communication#GO:0007154;secretion#GO:0046903;regulation of intracellular pH#GO:0051453;signal release#GO:0023061;trans-synaptic signaling#GO:0099537;organelle localization#GO:0051640;regulation of pH#GO:0006885;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;neurotransmitter secretion#GO:0007269;vesicle localization#GO:0051648;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;establishment of localization#GO:0051234;vacuolar acidification#GO:0007035;vacuolar transport#GO:0007034;intracellular monoatomic cation homeostasis#GO:0030003;synaptic vesicle cycle#GO:0099504;monoatomic cation homeostasis#GO:0055080;transport#GO:0006810;intracellular transport#GO:0046907;export from cell#GO:0140352;signaling#GO:0023052;establishment of organelle localization#GO:0051656;regulation of biological process#GO:0050789;intracellular monoatomic ion homeostasis#GO:0006873;secretion by cell#GO:0032940;regulation of biological quality#GO:0065008;cellular localization#GO:0051641;lysosomal transport#GO:0007041;neurotransmitter transport#GO:0006836;establishment of vesicle localization#GO:0051650;synaptic vesicle localization#GO:0097479;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;synaptic vesicle exocytosis#GO:0016079;cellular process#GO:0009987;synaptic vesicle transport#GO:0048489;synaptic signaling#GO:0099536;monoatomic ion homeostasis#GO:0050801;endosomal transport#GO:0016197;exocytosis#GO:0006887;vesicle-mediated transport in synapse#GO:0099003;chemical homeostasis#GO:0048878;regulated exocytosis#GO:0045055 secretory vesicle#GO:0099503;presynapse#GO:0098793;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;transport vesicle#GO:0030133;cytoplasm#GO:0005737;cell junction#GO:0030054;intracellular protein-containing complex#GO:0140535;intracellular vesicle#GO:0097708;synaptic vesicle#GO:0008021;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;BLOC-1 complex#GO:0031083;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=32521|UniProtKB=Q5FYB1 Q5FYB1 ARSI PTHR10342:SF68 ARYLSULFATASE ARYLSULFATASE I hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788 HUMAN|HGNC=5112|UniProtKB=Q92826 Q92826 HOXB13 PTHR45804:SF6 SEGMENTATION PROTEIN FUSHI TARAZU-LIKE PROTEIN HOMEOBOX PROTEIN HOX-B13 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=4474|UniProtKB=P46092 P46092 CCR10 PTHR10489:SF735 CELL ADHESION MOLECULE C-C CHEMOKINE RECEPTOR TYPE 10 transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488;protein binding#GO:0005515;molecular transducer activity#GO:0060089;cytokine receptor activity#GO:0004896;cytokine binding#GO:0019955;signaling receptor activity#GO:0038023;immune receptor activity#GO:0140375;G protein-coupled receptor activity#GO:0004930 calcium-mediated signaling#GO:0019722;response to external stimulus#GO:0009605;cell migration#GO:0016477;response to chemical#GO:0042221;taxis#GO:0042330;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;immune response#GO:0006955;cell communication#GO:0007154;regulation of biological quality#GO:0065008;intracellular signal transduction#GO:0035556;cell chemotaxis#GO:0060326;cellular response to chemical stimulus#GO:0070887;immune system process#GO:0002376;positive regulation of cytosolic calcium ion concentration#GO:0007204;chemotaxis#GO:0006935;cell motility#GO:0048870;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;locomotion#GO:0040011;signaling#GO:0023052;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789 external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552 cell adhesion molecule#PC00069 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CHKR#P00854 HUMAN|HGNC=914|UniProtKB=P61769 P61769 B2M PTHR19944:SF62 MHC CLASS II-RELATED BETA-2-MICROGLOBULIN peptide binding#GO:0042277;antigen binding#GO:0003823;binding#GO:0005488;protein-containing complex binding#GO:0044877 positive regulation of leukocyte activation#GO:0002696;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of immune system process#GO:0002684;cellular component biogenesis#GO:0044085;positive regulation of cell-cell adhesion#GO:0022409;regulation of multicellular organismal process#GO:0051239;regulation of T cell activation#GO:0050863;positive regulation of T cell activation#GO:0050870;cellular component assembly#GO:0022607;immune system process#GO:0002376;positive regulation of multicellular organismal process#GO:0051240;regulation of cell activation#GO:0050865;regulation of biological process#GO:0050789;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;regulation of leukocyte activation#GO:0002694;regulation of lymphocyte activation#GO:0051249;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;regulation of leukocyte cell-cell adhesion#GO:1903037;positive regulation of cellular process#GO:0048522;positive regulation of cell activation#GO:0050867;biological regulation#GO:0065007;positive regulation of leukocyte cell-cell adhesion#GO:1903039;regulation of cell adhesion#GO:0030155;positive regulation of response to stimulus#GO:0048584;regulation of immune response#GO:0050776;antigen processing and presentation#GO:0019882;positive regulation of lymphocyte activation#GO:0051251;positive regulation of cell adhesion#GO:0045785;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of cell-cell adhesion#GO:0022407 cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endosome membrane#GO:0010008;endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;lysosome#GO:0005764;plasma membrane protein complex#GO:0098797;vesicle#GO:0031982;membrane protein complex#GO:0098796;lytic vacuole membrane#GO:0098852;intracellular vesicle#GO:0097708;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;vacuolar membrane#GO:0005774;lytic vacuole#GO:0000323;late endosome membrane#GO:0031902;cytoplasm#GO:0005737;plasma membrane#GO:0005886;vacuole#GO:0005773;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;late endosome#GO:0005770;lysosomal membrane#GO:0005765;cell periphery#GO:0071944;membrane#GO:0016020;vesicle membrane#GO:0012506 major histocompatibility complex protein#PC00149 T cell activation#P00053>MHC-antigen#P01316 HUMAN|HGNC=18170|UniProtKB=P30085 P30085 CMPK1 PTHR23359:SF206 NUCLEOTIDE KINASE UMP-CMP KINASE transferase activity#GO:0016740;nucleobase-containing compound kinase activity#GO:0019205;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, phosphate group as acceptor#GO:0016776 nucleoside phosphate biosynthetic process#GO:1901293;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;ribose phosphate biosynthetic process#GO:0046390;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;pyrimidine-containing compound metabolic process#GO:0072527;ribose phosphate metabolic process#GO:0019693;nucleotide metabolic process#GO:0009117;organophosphate biosynthetic process#GO:0090407;nucleotide biosynthetic process#GO:0009165;nucleoside diphosphate metabolic process#GO:0009132;ribonucleotide metabolic process#GO:0009259;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;ribonucleoside diphosphate metabolic process#GO:0009185 nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 kinase#PC00137;nucleotide kinase#PC00172 De novo purine biosynthesis#P02738>Adenylate kinase#P02896;Salvage pyrimidine ribonucleotides#P02775>Cytidylate kinase#P03153;De novo pyrimidine ribonucleotides biosythesis#P02740>Uridylate kinase#P02924 HUMAN|HGNC=7051|UniProtKB=O75556 O75556 SCGB2A1 PTHR14037:SF4 MAMMAGLOBIN-RELATED MAMMAGLOBIN-B cellular response to steroid hormone stimulus#GO:0071383;biological regulation#GO:0065007;cellular response to lipid#GO:0071396;response to lipid#GO:0033993;response to chemical#GO:0042221;nuclear receptor-mediated signaling pathway#GO:0141193;cellular process#GO:0009987;nuclear receptor-mediated steroid hormone signaling pathway#GO:0030518;signal transduction#GO:0007165;response to hormone#GO:0009725;intracellular signal transduction#GO:0035556;hormone-mediated signaling pathway#GO:0009755;cell communication#GO:0007154;response to steroid hormone#GO:0048545;cellular response to chemical stimulus#GO:0070887;signaling#GO:0023052;intracellular receptor signaling pathway#GO:0030522;cellular response to hormone stimulus#GO:0032870;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;cellular response to stimulus#GO:0051716;steroid hormone receptor signaling pathway#GO:0043401;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=7454|UniProtKB=Q9Y216 Q9Y216 MTMR7 PTHR10807:SF35 MYOTUBULARIN-RELATED PHOSPHATIDYLINOSITOL-3-PHOSPHATE PHOSPHATASE MTMR7 hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787 phospholipid dephosphorylation#GO:0046839;cellular process#GO:0009987;phosphate-containing compound metabolic process#GO:0006796;organophosphate metabolic process#GO:0019637;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phospholipid metabolic process#GO:0006644;glycerolipid metabolic process#GO:0046486;glycerophospholipid metabolic process#GO:0006650;lipid metabolic process#GO:0006629;phosphatidylinositol metabolic process#GO:0046488;metabolic process#GO:0008152;phosphatidylinositol dephosphorylation#GO:0046856;lipid modification#GO:0030258;dephosphorylation#GO:0016311 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;membrane#GO:0016020 phosphatase#PC00181 HUMAN|HGNC=23317|UniProtKB=P61647 P61647 ST8SIA6 PTHR11987:SF29 ALPHA-2,8-SIALYLTRANSFERASE ALPHA-2,8-SIALYLTRANSFERASE 8F sialyltransferase activity#GO:0008373;glycosyltransferase activity#GO:0016757;transferase activity#GO:0016740;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;oligosaccharide metabolic process#GO:0009311;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;biosynthetic process#GO:0009058;carbohydrate metabolic process#GO:0005975;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 metabolite interconversion enzyme#PC00262;transferase#PC00220 HUMAN|HGNC=15467|UniProtKB=Q8TF09 Q8TF09 DYNLRB2 PTHR10779:SF31 DYNEIN LIGHT CHAIN ROADBLOCK DYNEIN LIGHT CHAIN ROADBLOCK-TYPE 2 binding#GO:0005488;protein binding#GO:0005515 cellular process#GO:0009987;microtubule-based movement#GO:0007018;microtubule-based process#GO:0007017 cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;cytoplasmic dynein complex#GO:0005868;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;centrosome#GO:0005813;microtubule organizing center#GO:0005815;cellular anatomical structure#GO:0110165;organelle#GO:0043226;dynein complex#GO:0030286;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;catalytic complex#GO:1902494 microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=25083|UniProtKB=Q8N0Z3 Q8N0Z3 SPICE1 PTHR31167:SF3 SPINDLE AND CENTRIOLE ASSOCIATED PROTEIN 1 SPICE1 SPINDLE AND CENTRIOLE-ASSOCIATED PROTEIN 1 spindle organization#GO:0007051;mitotic cell cycle process#GO:1903047;chromosome organization#GO:0051276;biological regulation#GO:0065007;mitotic sister chromatid segregation#GO:0000070;regulation of organelle assembly#GO:1902115;mitotic spindle assembly#GO:0090307;localization#GO:0051179;organelle fission#GO:0048285;microtubule cytoskeleton organization#GO:0000226;organelle assembly#GO:0070925;regulation of microtubule-based process#GO:0032886;organelle localization#GO:0051640;mitotic cell cycle#GO:0000278;regulation of cellular process#GO:0050794;cell cycle#GO:0007049;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;metaphase chromosome alignment#GO:0051310;chromosome segregation#GO:0007059;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;regulation of cell cycle process#GO:0010564;chromosome localization#GO:0050000;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;spindle assembly#GO:0051225;cellular process#GO:0009987;nuclear division#GO:0000280;regulation of cellular component organization#GO:0051128;mitotic spindle organization#GO:0007052;regulation of cell cycle#GO:0051726;regulation of cellular component biogenesis#GO:0044087;nuclear chromosome segregation#GO:0098813;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;sister chromatid segregation#GO:0000819;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;cell cycle process#GO:0022402;mitotic nuclear division#GO:0140014 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;centrosome#GO:0005813;spindle#GO:0005819;microtubule organizing center#GO:0005815;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;centriole#GO:0005814;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=26191|UniProtKB=Q9H6B1 Q9H6B1 ZNF385D PTHR23067:SF12 DOUBLE-STRANDED RNA-BINDING ZINC FINGER PROTEIN ZINC FINGER PROTEIN 385D intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=6824|UniProtKB=Q16706 Q16706 MAN2A1 PTHR11607:SF69 ALPHA-MANNOSIDASE ALPHA-MANNOSIDASE 2 hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787 biosynthetic process#GO:0009058;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100 membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020 hydrolase#PC00121;glycosidase#PC00110 HUMAN|HGNC=3757|UniProtKB=O75955 O75955 FLOT1 PTHR13806:SF47 FLOTILLIN-RELATED FLOTILLIN-1 biological regulation#GO:0065007;regulation of receptor-mediated endocytosis#GO:0048259;positive regulation of endocytosis#GO:0045807;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of transport#GO:0051050;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;regulation of localization#GO:0032879;regulation of transport#GO:0051049;positive regulation of cellular component organization#GO:0051130;regulation of endocytosis#GO:0030100 cytoplasm#GO:0005737;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;plasma membrane region#GO:0098590;cell periphery#GO:0071944;caveola#GO:0005901;membrane#GO:0016020;membrane microdomain#GO:0098857;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane protein complex#GO:0098797;vesicle#GO:0031982;membrane raft#GO:0045121;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;plasma membrane raft#GO:0044853;intracellular organelle#GO:0043229 HUMAN|HGNC=28020|UniProtKB=Q86TI4 Q86TI4 WDR86 PTHR44489:SF19 FAMILY NOT NAMED WD REPEAT-CONTAINING PROTEIN 86 HUMAN|HGNC=19248|UniProtKB=Q8WVN8 Q8WVN8 UBE2Q2 PTHR24068:SF456 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2 Q2 ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-like protein conjugating enzyme activity#GO:0061650;ubiquitin-protein transferase activity#GO:0004842;transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;ubiquitin conjugating enzyme activity#GO:0061631;catalytic activity, acting on a protein#GO:0140096 protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein K48-linked ubiquitination#GO:0070936;protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;protein modification process#GO:0036211;primary metabolic process#GO:0044238;cellular process#GO:0009987;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=10487|UniProtKB=P60903 P60903 S100A10 PTHR11639:SF74 S100 CALCIUM-BINDING PROTEIN PROTEIN S100-A10 cation binding#GO:0043169;protein binding#GO:0005515;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;transmembrane transporter binding#GO:0044325;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094 calmodulin-related#PC00061;calcium-binding protein#PC00060 HUMAN|HGNC=3587|UniProtKB=Q9NPI8 Q9NPI8 FANCF PTHR14449:SF2 FANCONI ANEMIA GROUP F PROTEIN FANCF FANCONI ANEMIA GROUP F PROTEIN response to stress#GO:0006950;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;response to stimulus#GO:0050896 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;Fanconi anaemia nuclear complex#GO:0043240;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 HUMAN|HGNC=9536|UniProtKB=O14818 O14818 PSMA7 PTHR11599:SF40 PROTEASOME SUBUNIT ALPHA/BETA PROTEASOME SUBUNIT ALPHA TYPE-7 primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511 membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;endopeptidase complex#GO:1905369;peptidase complex#GO:1905368;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;proteasome complex#GO:0000502 protease#PC00190;protein modifying enzyme#PC00260 Parkinson disease#P00049>20S proteasome#P01227 HUMAN|HGNC=8073|UniProtKB=Q9H4D5 Q9H4D5 NXF3 PTHR10662:SF12 NUCLEAR RNA EXPORT FACTOR NUCLEAR RNA EXPORT FACTOR 3 binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 establishment of RNA localization#GO:0051236;mRNA transport#GO:0051028;nucleobase-containing compound transport#GO:0015931;RNA localization#GO:0006403;RNA transport#GO:0050658;nuclear transport#GO:0051169;nuclear export#GO:0051168;localization#GO:0051179;nucleic acid transport#GO:0050657;cellular localization#GO:0051641;mRNA export from nucleus#GO:0006406;nucleocytoplasmic transport#GO:0006913;biosynthetic process#GO:0009058;gene expression#GO:0010467;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule localization#GO:0033036;nitrogen compound transport#GO:0071705;poly(A)+ mRNA export from nucleus#GO:0016973;macromolecule metabolic process#GO:0043170;establishment of localization#GO:0051234;transport#GO:0006810;metabolic process#GO:0008152;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031 HUMAN|HGNC=18040|UniProtKB=Q8NFD5 Q8NFD5 ARID1B PTHR12656:SF11 BRG-1 ASSOCIATED FACTOR 250 BAF250 AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 1B chromatin binding#GO:0003682;binding#GO:0005488;nucleosome binding#GO:0031491;protein-containing complex binding#GO:0044877 regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of RNA metabolic process#GO:0051252;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;chromatin#GO:0000785;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;catalytic complex#GO:1902494;SWI/SNF complex#GO:0016514;intracellular organelle#GO:0043229;ATPase complex#GO:1904949;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;organelle lumen#GO:0043233;SWI/SNF superfamily-type complex#GO:0070603 Wnt signaling pathway#P00057>SWI/SNF#P01435 HUMAN|HGNC=24103|UniProtKB=Q9H1I8 Q9H1I8 ASCC2 PTHR21494:SF3 ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2 ASC-1 COMPLEX SUBUNIT P100 ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2 ubiquitin binding#GO:0043130;binding#GO:0005488;protein binding#GO:0005515 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 HUMAN|HGNC=1602|UniProtKB=P32246 P32246 CCR1 PTHR10489:SF711 CELL ADHESION MOLECULE C-C CHEMOKINE RECEPTOR TYPE 1 protein binding#GO:0005515;molecular transducer activity#GO:0060089;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888;immune receptor activity#GO:0140375;G protein-coupled receptor activity#GO:0004930;cytokine binding#GO:0019955;signaling receptor activity#GO:0038023;cytokine receptor activity#GO:0004896 signaling#GO:0023052;locomotion#GO:0040011;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell motility#GO:0048870;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell chemotaxis#GO:0060326;regulation of biological quality#GO:0065008;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;chemotaxis#GO:0006935;inflammatory response#GO:0006954;immune system process#GO:0002376;positive regulation of cytosolic calcium ion concentration#GO:0007204;cellular response to chemical stimulus#GO:0070887;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124;taxis#GO:0042330;response to chemical#GO:0042221;cell migration#GO:0016477;signal transduction#GO:0007165;immune response#GO:0006955;cellular process#GO:0009987;response to stress#GO:0006950;response to external stimulus#GO:0009605;defense response#GO:0006952;calcium-mediated signaling#GO:0019722 external side of plasma membrane#GO:0009897;intracellular anatomical structure#GO:0005622;side of membrane#GO:0098552;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;cell surface#GO:0009986;cellular anatomical structure#GO:0110165 cell adhesion molecule#PC00069 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CHKR#P00854 HUMAN|HGNC=25763|UniProtKB=Q9H0W8 Q9H0W8 SMG9 PTHR14270:SF0 NONSENSE-MEDIATED MRNA DECAY FACTOR SMG9 NONSENSE-MEDIATED MRNA DECAY FACTOR SMG9 metabolic process#GO:0008152;negative regulation of cellular process#GO:0048523;macromolecule catabolic process#GO:0009057;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay#GO:0000184;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of gene expression#GO:0010468;nucleobase-containing compound catabolic process#GO:0034655;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;nucleic acid catabolic process#GO:0141188;cellular process#GO:0009987;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;RNA catabolic process#GO:0006401;RNA metabolic process#GO:0016070;negative regulation of biological process#GO:0048519;nucleic acid metabolic process#GO:0090304;negative regulation of gene expression#GO:0010629;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892 HUMAN|HGNC=8807|UniProtKB=P29803 P29803 PDHA2 PTHR11516:SF27 PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA, TESTIS-SPECIFIC FORM, MITOCHONDRIAL oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the aldehyde or oxo group of donors#GO:0016903 acetyl-CoA metabolic process#GO:0006084;oxoacid metabolic process#GO:0043436;purine-containing compound biosynthetic process#GO:0072522;organophosphate biosynthetic process#GO:0090407;cellular respiration#GO:0045333;aerobic respiration#GO:0009060;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;purine-containing compound metabolic process#GO:0072521;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;pyruvate metabolic process#GO:0006090;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091;energy derivation by oxidation of organic compounds#GO:0015980;nucleoside phosphate biosynthetic process#GO:1901293;acyl-CoA metabolic process#GO:0006637;nucleobase-containing small molecule metabolic process#GO:0055086;sulfur compound metabolic process#GO:0006790;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139 membrane-bounded organelle#GO:0043227;acetyltransferase complex#GO:1902493;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;mitochondrion#GO:0005739;transferase complex#GO:1990234;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;membrane-enclosed lumen#GO:0031974;oxidoreductase complex#GO:1990204 oxidoreductase#PC00176;dehydrogenase#PC00092 Pyruvate metabolism#P02772>Pyruvate Dehydrogenase#P03133;TCA cycle#P00051>Pyruvate Dehydrogenase#P01266 HUMAN|HGNC=8540|UniProtKB=Q96G91 Q96G91 P2RY11 PTHR24231:SF46 PURINOCEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR P2Y PURINOCEPTOR 11 neurotransmitter receptor activity#GO:0030594;transmembrane signaling receptor activity#GO:0004888;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;G protein-coupled receptor signaling pathway#GO:0007186;intracellular signal transduction#GO:0035556;calcium-mediated signaling#GO:0019722;cell communication#GO:0007154 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=19405|UniProtKB=Q8N414 Q8N414 PGBD5 PTHR28576:SF2 PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 5 PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 5 viral or transposable element protein#PC00237 HUMAN|HGNC=20391|UniProtKB=Q8IWU6 Q8IWU6 SULF1 PTHR43108:SF1 N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER EXTRACELLULAR SULFATASE SULF-1 hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788 negative regulation of response to stimulus#GO:0048585;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of cellular response to growth factor stimulus#GO:0090287;regulation of signal transduction#GO:0009966;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of cytokine production#GO:0001817;positive regulation of cellular process#GO:0048522;carbohydrate derivative metabolic process#GO:1901135;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulation of gene expression#GO:0010468;positive regulation of gene expression#GO:0010628;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;positive regulation of cell communication#GO:0010647;positive regulation of cytokine production#GO:0001819;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;carbohydrate derivative catabolic process#GO:1901136;regulation of cell communication#GO:0010646;primary metabolic process#GO:0044238;positive regulation of signal transduction#GO:0009967;protein metabolic process#GO:0019538;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of Wnt signaling pathway#GO:0030177;negative regulation of signal transduction#GO:0009968;regulation of multicellular organismal process#GO:0051239;regulation of fibroblast growth factor receptor signaling pathway#GO:0040036;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;proteoglycan metabolic process#GO:0006029;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;regulation of Wnt signaling pathway#GO:0030111;negative regulation of biological process#GO:0048519;positive regulation of multicellular organismal process#GO:0051240;regulation of biological process#GO:0050789;positive regulation of signaling#GO:0023056;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;negative regulation of cell communication#GO:0010648;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;protein catabolic process#GO:0030163 extracellular region#GO:0005576;cell surface#GO:0009986;cellular anatomical structure#GO:0110165 hydrolase#PC00121 HUMAN|HGNC=1395|UniProtKB=O95180 O95180 CACNA1H PTHR10037:SF192 VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1H voltage-gated calcium channel activity#GO:0005245;channel activity#GO:0015267;monoatomic cation channel activity#GO:0005261;sodium ion transmembrane transporter activity#GO:0015081;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;sodium channel activity#GO:0005272;voltage-gated channel activity#GO:0022832;calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;voltage-gated sodium channel activity#GO:0005248;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;transporter activity#GO:0005215 regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;calcium ion transport#GO:0006816;regulation of transport#GO:0051049;regulation of localization#GO:0032879;transport#GO:0006810;biological regulation#GO:0065007;positive regulation of biological process#GO:0048518;positive regulation of secretion by cell#GO:1903532;positive regulation of transport#GO:0051050;positive regulation of cellular process#GO:0048522;regulation of secretion#GO:0051046;localization#GO:0051179;monoatomic cation transport#GO:0006812;regulation of secretion by cell#GO:1903530;regulation of biological quality#GO:0065008;regulation of exocytosis#GO:0017157;monoatomic ion transport#GO:0006811;positive regulation of secretion#GO:0051047;regulation of cellular process#GO:0050794;membrane depolarization#GO:0051899;metal ion transport#GO:0030001;calcium ion import#GO:0070509;regulation of vesicle-mediated transport#GO:0060627;action potential#GO:0001508;regulation of biological process#GO:0050789 sodium channel complex#GO:0034706;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;cation channel complex#GO:0034703;cell projection#GO:0042995;plasma membrane#GO:0005886;plasma membrane bounded cell projection#GO:0120025;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;neuron projection#GO:0043005;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane protein complex#GO:0098796;membrane#GO:0016020 voltage-gated ion channel#PC00241 HUMAN|HGNC=2152|UniProtKB=Q8IV77 Q8IV77 CNGA4 PTHR45638:SF2 CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A CYCLIC NUCLEOTIDE-GATED CHANNEL ALPHA-4 transporter activity#GO:0005215;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleotide binding#GO:0032555;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;heterocyclic compound binding#GO:1901363;gated channel activity#GO:0022836;guanyl nucleotide binding#GO:0019001;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;guanyl ribonucleotide binding#GO:0032561;monoatomic cation transmembrane transporter activity#GO:0008324;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;nucleotide binding#GO:0000166;monoatomic cation channel activity#GO:0005261;ligand-gated monoatomic ion channel activity#GO:0015276;ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;channel activity#GO:0015267 sensory perception of chemical stimulus#GO:0007606;sensory perception#GO:0007600;nervous system process#GO:0050877;transport#GO:0006810;localization#GO:0051179;monoatomic cation transport#GO:0006812;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;system process#GO:0003008;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;multicellular organismal process#GO:0032501;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220 cell periphery#GO:0071944;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;cation channel complex#GO:0034703;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495 ligand-gated ion channel#PC00141;ion channel#PC00133 HUMAN|HGNC=15898|UniProtKB=Q9H501 Q9H501 ESF1 PTHR12202:SF0 ESF1 HOMOLOG ESF1 HOMOLOG nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 HUMAN|HGNC=49396|UniProtKB=P0DMB1 P0DMB1 PRR23D2 PTHR31813:SF3 PROLINE-RICH PROTEIN 23B PROLINE-RICH PROTEIN 23D1-RELATED HUMAN|HGNC=15484|UniProtKB=O75971 O75971 SNAPC5 PTHR15333:SF2 SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 5 SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 5 HUMAN|HGNC=12436|UniProtKB=O43396 O43396 TXNL1 PTHR46115:SF1 THIOREDOXIN-LIKE PROTEIN 1 THIOREDOXIN-LIKE PROTEIN 1 catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491;protein-disulfide reductase activity#GO:0015035;disulfide oxidoreductase activity#GO:0015036;catalytic activity#GO:0003824;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 oxidoreductase#PC00176 Oxidative stress response#P00046>TRX#P01122 HUMAN|HGNC=2986|UniProtKB=Q14184 Q14184 DOC2B PTHR45729:SF9 RABPHILIN, ISOFORM A DOUBLE C2-LIKE DOMAIN-CONTAINING PROTEIN BETA regulation of exocytosis#GO:0017157;localization#GO:0051179;regulation of secretion#GO:0051046;cell communication#GO:0007154;secretion#GO:0046903;signal release#GO:0023061;trans-synaptic signaling#GO:0099537;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;signal release from synapse#GO:0099643;chemical synaptic transmission#GO:0007268;establishment of localization#GO:0051234;synaptic vesicle cycle#GO:0099504;transport#GO:0006810;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;neurotransmitter secretion#GO:0007269;positive regulation of cellular process#GO:0048522;secretion by cell#GO:0032940;regulation of secretion by cell#GO:1903530;cellular localization#GO:0051641;positive regulation of organelle organization#GO:0010638;positive regulation of secretion#GO:0051047;positive regulation of cellular component organization#GO:0051130;signaling#GO:0023052;export from cell#GO:0140352;regulation of cellular component organization#GO:0051128;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;regulation of organelle organization#GO:0033043;regulation of transport#GO:0051049;exocytosis#GO:0006887;regulation of localization#GO:0032879;positive regulation of vesicle fusion#GO:0031340;vesicle-mediated transport in synapse#GO:0099003;regulated exocytosis#GO:0045055;neurotransmitter transport#GO:0006836;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;positive regulation of transport#GO:0051050;synaptic vesicle exocytosis#GO:0016079;positive regulation of biological process#GO:0048518;positive regulation of secretion by cell#GO:1903532;cellular process#GO:0009987;synaptic signaling#GO:0099536 cell junction#GO:0030054;cellular anatomical structure#GO:0110165;synapse#GO:0045202 HUMAN|HGNC=7787|UniProtKB=Q16649 Q16649 NFIL3 PTHR15284:SF1 NUCLEAR FACTOR INTERLEUKIN-3-REGULATED PROTEIN NUCLEAR FACTOR INTERLEUKIN-3-REGULATED PROTEIN regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;circadian rhythm#GO:0007623;rhythmic process#GO:0048511 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 basic leucine zipper transcription factor#PC00056;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=29148|UniProtKB=P0C2W1 P0C2W1 FBXO45 PTHR12245:SF7 SPRY DOMAIN CONTAINING SOCS BOX PROTEIN F-BOX_SPRY DOMAIN-CONTAINING PROTEIN 1 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;enzyme-substrate adaptor activity#GO:0140767;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 cell junction assembly#GO:0034329;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;synapse assembly#GO:0007416;cell junction organization#GO:0034330;animal gross anatomical part developmental process#GO:0160108;protein catabolic process#GO:0030163;synapse organization#GO:0050808;modification-dependent macromolecule catabolic process#GO:0043632;anatomical structure development#GO:0048856;protein metabolic process#GO:0019538;system development#GO:0048731;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cellular component assembly#GO:0022607;multicellular organismal process#GO:0032501;proteasomal protein catabolic process#GO:0010498;nervous system development#GO:0007399;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;developmental process#GO:0032502;multicellular organism development#GO:0007275;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;ubiquitin-dependent protein catabolic process#GO:0006511 cullin-RING ubiquitin ligase complex#GO:0031461;SCF ubiquitin ligase complex#GO:0019005;cellular anatomical structure#GO:0110165;synapse#GO:0045202;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;cell junction#GO:0030054;ubiquitin ligase complex#GO:0000151 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=39755|UniProtKB=E2RYF6 E2RYF6 MUC22 PTHR37000:SF3 MUCIN-22 MUCIN-22 HUMAN|HGNC=16273|UniProtKB=Q96A49 Q96A49 SYAP1 PTHR16019:SF6 SYNAPSE-ASSOCIATED PROTEIN SYNAPSE-ASSOCIATED PROTEIN 1 positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;biological regulation#GO:0065007;TOR signaling#GO:0031929;positive regulation of developmental process#GO:0051094;regulation of cell differentiation#GO:0045595;positive regulation of cell differentiation#GO:0045597;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;TORC2 signaling#GO:0038203;regulation of developmental process#GO:0050793;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;positive regulation of fat cell differentiation#GO:0045600;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;synapse#GO:0045202;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634;cell junction#GO:0030054;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 HUMAN|HGNC=28860|UniProtKB=Q9H2J4 Q9H2J4 PDCL3 PTHR45809:SF4 VIRAL IAP-ASSOCIATED FACTOR HOMOLOG PHOSDUCIN-LIKE PROTEIN 3 binding#GO:0005488;signaling receptor binding#GO:0005102;cytokine receptor binding#GO:0005126;growth factor receptor binding#GO:0070851;protein binding#GO:0005515 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;tube morphogenesis#GO:0035239;blood vessel development#GO:0001568;primary metabolic process#GO:0044238;system development#GO:0048731;protein metabolic process#GO:0019538;anatomical structure development#GO:0048856;positive regulation of biosynthetic process#GO:0009891;tube development#GO:0035295;biological regulation#GO:0065007;biosynthetic process#GO:0009058;multicellular organismal process#GO:0032501;macromolecule biosynthetic process#GO:0009059;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;positive regulation of gene expression#GO:0010628;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;developmental process#GO:0032502;protein folding#GO:0006457;circulatory system development#GO:0072359;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;blood vessel morphogenesis#GO:0048514;angiogenesis#GO:0001525;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;animal gross anatomical part developmental process#GO:0160108;protein maturation#GO:0051604;gene expression#GO:0010467;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;anatomical structure formation involved in morphogenesis#GO:0048646;vasculature development#GO:0001944;multicellular organism development#GO:0007275;metabolic process#GO:0008152 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 viral or transposable element protein#PC00237 HUMAN|HGNC=18606|UniProtKB=Q9BYC2 Q9BYC2 OXCT2 PTHR13707:SF28 KETOACID-COENZYME A TRANSFERASE SUCCINYL-COA:3-KETOACID COENZYME A TRANSFERASE 2, MITOCHONDRIAL transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring sulphur-containing groups#GO:0016782 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 transferase#PC00220;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=30301|UniProtKB=Q96JE7 Q96JE7 SEC16B PTHR13402:SF11 RGPR-RELATED PROTEIN TRANSPORT PROTEIN SEC16B cytoplasmic vesicle membrane#GO:0030659;transport vesicle membrane#GO:0030658;endomembrane system#GO:0012505;transport vesicle#GO:0030133;cytoplasm#GO:0005737;membrane#GO:0016020;vesicle membrane#GO:0012506;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;endoplasmic reticulum exit site#GO:0070971;endoplasmic reticulum#GO:0005783;ER to Golgi transport vesicle membrane#GO:0012507;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;coated vesicle membrane#GO:0030662;intracellular vesicle#GO:0097708;vesicle#GO:0031982;COPII-coated ER to Golgi transport vesicle#GO:0030134;cytoplasmic vesicle#GO:0031410;coated vesicle#GO:0030135;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HUMAN|HGNC=26438|UniProtKB=Q4KMG9 Q4KMG9 TMEM52B PTHR33955:SF1 TRANSMEMBRANE PROTEIN 52 TRANSMEMBRANE PROTEIN 52B HUMAN|HGNC=21948|UniProtKB=Q6NUN9 Q6NUN9 ZNF746 PTHR23232:SF118 KRAB DOMAIN C2H2 ZINC FINGER ZINC FINGER PROTEIN 746-RELATED sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific DNA binding#GO:0043565;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;DNA-binding transcription repressor activity#GO:0001217;transcription regulatory region nucleic acid binding#GO:0001067 regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=25355|UniProtKB=Q6XR72 Q6XR72 SLC30A10 PTHR45820:SF3 FI23527P1 CALCIUM_MANGANESE ANTIPORTER SLC30A10 monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation transmembrane transporter activity#GO:0008324;metal ion transmembrane transporter activity#GO:0046873;zinc ion transmembrane transporter activity#GO:0005385;transition metal ion transmembrane transporter activity#GO:0046915;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 response to stress#GO:0006950;detoxification of inorganic compound#GO:0061687;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;response to chemical#GO:0042221;zinc ion transport#GO:0006829;monoatomic ion transmembrane transport#GO:0034220;detoxification#GO:0098754;monoatomic cation transmembrane transport#GO:0098655;monoatomic cation homeostasis#GO:0055080;transport#GO:0006810;intracellular monoatomic cation homeostasis#GO:0030003;chemical homeostasis#GO:0048878;response to metal ion#GO:0010038;establishment of localization#GO:0051234;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;intracellular monoatomic ion homeostasis#GO:0006873;response to toxic substance#GO:0009636;response to stimulus#GO:0050896;homeostatic process#GO:0042592;metal ion transport#GO:0030001;inorganic ion homeostasis#GO:0098771;transition metal ion transport#GO:0000041;zinc ion transmembrane transport#GO:0071577;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811 membrane#GO:0016020;cellular anatomical structure#GO:0110165 HUMAN|HGNC=1719|UniProtKB=O60729 O60729 CDC14B PTHR23339:SF74 TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE DUAL SPECIFICITY PROTEIN PHOSPHATASE CDC14B protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096 regulation of cytokinesis#GO:0032465;regulation of cell division#GO:0051302;organelle assembly#GO:0070925;cilium organization#GO:0044782;microtubule cytoskeleton organization#GO:0000226;regulation of mitotic cell cycle phase transition#GO:1901990;regulation of biological process#GO:0050789;positive regulation of cell cycle process#GO:0090068;cellular component organization#GO:0016043;cilium assembly#GO:0060271;regulation of cell cycle phase transition#GO:1901987;regulation of cell cycle#GO:0051726;regulation of cellular process#GO:0050794;cell projection organization#GO:0030030;plasma membrane bounded cell projection assembly#GO:0120031;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;regulation of mitotic cell cycle#GO:0007346;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cell projection assembly#GO:0030031;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;positive regulation of cell cycle#GO:0045787;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;regulation of cell cycle process#GO:0010564;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;mitotic spindle#GO:0072686;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;microtubule organizing center#GO:0005815;spindle#GO:0005819;centrosome#GO:0005813;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;nucleus#GO:0005634;microtubule cytoskeleton#GO:0015630;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737 protein modifying enzyme#PC00260;protein phosphatase#PC00195 HUMAN|HGNC=48576|UniProtKB=A0A1B0GWG4 A0A1B0GWG4 SERTM2 PTHR35660:SF2 SERINE-RICH AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 1 SERINE-RICH AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 2 HUMAN|HGNC=3697|UniProtKB=P09769 P09769 FGR PTHR24418:SF224 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE FGR protein binding#GO:0005515;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;binding#GO:0005488;signaling receptor binding#GO:0005102;non-membrane spanning protein tyrosine kinase activity#GO:0004715;catalytic activity, acting on a protein#GO:0140096;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;signaling#GO:0023052;response to stimulus#GO:0050896;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;integrin-mediated signaling pathway#GO:0007229;cellular developmental process#GO:0048869;developmental process#GO:0032502;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;signal transduction#GO:0007165;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 non-receptor tyrosine protein kinase#PC00168 Parkinson disease#P00049>Src kinase#P01230 HUMAN|HGNC=16874|UniProtKB=Q7L1I2 Q7L1I2 SV2B PTHR23511:SF2 SYNAPTIC VESICLE GLYCOPROTEIN 2 SYNAPTIC VESICLE GLYCOPROTEIN 2B monoatomic ion homeostasis#GO:0050801;biological regulation#GO:0065007;regulation of trans-synaptic signaling#GO:0099177;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;intracellular monoatomic cation homeostasis#GO:0030003;regulation of transport#GO:0051049;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;regulation of localization#GO:0032879;cellular homeostasis#GO:0019725;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;regulation of cytosolic calcium ion concentration#GO:0051480;intracellular monoatomic ion homeostasis#GO:0006873;homeostatic process#GO:0042592;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;regulation of synaptic vesicle exocytosis#GO:2000300;regulation of neurotransmitter secretion#GO:0046928;regulation of cellular process#GO:0050794;regulation of signaling#GO:0023051;inorganic ion homeostasis#GO:0098771;regulation of neurotransmitter transport#GO:0051588;calcium ion homeostasis#GO:0055074;regulation of exocytosis#GO:0017157;regulation of secretion by cell#GO:1903530;regulation of secretion#GO:0051046 cell junction#GO:0030054;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;endomembrane system#GO:0012505;transport vesicle membrane#GO:0030658;cytoplasmic vesicle membrane#GO:0030659;transport vesicle#GO:0030133;cytoplasm#GO:0005737;membrane#GO:0016020;secretory vesicle#GO:0099503;vesicle membrane#GO:0012506;presynapse#GO:0098793;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;synaptic vesicle#GO:0008021;synaptic vesicle membrane#GO:0030672;vesicle#GO:0031982 HUMAN|HGNC=7602|UniProtKB=Q9Y4I1 Q9Y4I1 MYO5A PTHR13140:SF273 MYOSIN UNCONVENTIONAL MYOSIN-VA polypeptide conformation or assembly isomerase activity#GO:0120544;catalytic activity#GO:0003824;microfilament motor activity#GO:0000146;macromolecular conformation isomerase activity#GO:0120543;ATP-dependent activity#GO:0140657;cytoskeletal motor activity#GO:0003774;isomerase activity#GO:0016853 actin cytoskeleton organization#GO:0030036;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;actin filament organization#GO:0007015;supramolecular fiber organization#GO:0097435;actin filament-based process#GO:0030029 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;membrane#GO:0016020;actin cytoskeleton#GO:0015629;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226 actin binding motor protein#PC00040 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HUMAN|HGNC=20084|UniProtKB=Q8TDD1 Q8TDD1 DDX54 PTHR24031:SF292 RNA HELICASE ATP-DEPENDENT RNA HELICASE DDX54 rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;ribosomal large subunit biogenesis#GO:0042273;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;biosynthetic process#GO:0009058;maturation of LSU-rRNA#GO:0000470;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085 membraneless organelle#GO:0043228;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;preribosome, large subunit precursor#GO:0030687;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;preribosome#GO:0030684;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233 RNA metabolism protein#PC00031;RNA helicase#PC00032 HUMAN|HGNC=12520|UniProtKB=Q92890 Q92890 UFD1 PTHR12555:SF20 UBIQUITIN FUSION DEGRADATON PROTEIN 1 UBIQUITIN RECOGNITION FACTOR IN ER-ASSOCIATED DEGRADATION PROTEIN 1 modification-dependent protein binding#GO:0140030;binding#GO:0005488;polyubiquitin modification-dependent protein binding#GO:0031593;protein binding#GO:0005515 macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;response to chemical#GO:0042221;proteasomal protein catabolic process#GO:0010498;response to stress#GO:0006950;cellular process#GO:0009987;protein metabolic process#GO:0019538;ERAD pathway#GO:0036503;response to endoplasmic reticulum stress#GO:0034976;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;catabolic process#GO:0009056;response to stimulus#GO:0050896;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716 cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasm#GO:0005737;membrane#GO:0016020;organelle membrane#GO:0031090;endoplasmic reticulum protein-containing complex#GO:0140534;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783 HUMAN|HGNC=5467|UniProtKB=P11717 P11717 IGF2R PTHR15071:SF17 MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR protein binding#GO:0005515;growth factor binding#GO:0019838;binding#GO:0005488 protein targeting to vacuole#GO:0006623;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;transport#GO:0006810;intracellular protein transport#GO:0006886;vacuolar transport#GO:0007034;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;intracellular protein localization#GO:0008104;protein localization to lysosome#GO:0061462;protein targeting#GO:0006605;protein localization to organelle#GO:0033365;establishment of protein localization to vacuole#GO:0072666;protein localization to vacuole#GO:0072665;lysosomal transport#GO:0007041;cellular localization#GO:0051641;localization#GO:0051179;protein transport#GO:0015031 Golgi apparatus#GO:0005794;cell periphery#GO:0071944;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;plasma membrane#GO:0005886;late endosome#GO:0005770;endomembrane system#GO:0012505;endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 membrane traffic protein#PC00150 Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>INSR IGF-R IRR#P00885;Apoptosis signaling pathway#P00006>IGFR2#P00282;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>INSR IGF-R IRR#P00895 HUMAN|HGNC=9516|UniProtKB=Q9UQ72 Q9UQ72 PSG11 PTHR44337:SF15 CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 8 PREGNANCY-SPECIFIC BETA-1-GLYCOPROTEIN 11-RELATED cell-cell adhesion#GO:0098609;homophilic cell-cell adhesion#GO:0007156;heterophilic cell-cell adhesion#GO:0007157;cellular process#GO:0009987;cell adhesion#GO:0007155 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 immunoglobulin superfamily cell adhesion molecule#PC00125;cell adhesion molecule#PC00069 HUMAN|HGNC=5425|UniProtKB=P05014 P05014 IFNA4 PTHR11691:SF66 TYPE I INTERFERON INTERFERON ALPHA-10-RELATED molecular function activator activity#GO:0140677;protein-containing complex binding#GO:0044877;protein binding#GO:0005515;cytokine activity#GO:0005125;signaling receptor binding#GO:0005102;binding#GO:0005488;cytokine receptor binding#GO:0005126;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545 leukocyte activation#GO:0045321;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;response to external biotic stimulus#GO:0043207;cytokine-mediated signaling pathway#GO:0019221;cell activation#GO:0001775;cell communication#GO:0007154;response to nitrogen compound#GO:1901698;immune response#GO:0006955;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;adaptive immune response#GO:0002250;response to other organism#GO:0051707;innate immune response#GO:0045087;response to external stimulus#GO:0009605;defense response#GO:0006952;T cell activation#GO:0042110;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;immune system process#GO:0002376;B cell activation involved in immune response#GO:0002312;type I interferon-mediated signaling pathway#GO:0060337;cell activation involved in immune response#GO:0002263;response to peptide#GO:1901652;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;signal transduction#GO:0007165;defense response to symbiont#GO:0140546;lymphocyte activation involved in immune response#GO:0002285;cellular process#GO:0009987;response to cytokine#GO:0034097;lymphocyte activation#GO:0046649;response to chemical#GO:0042221;defense response to other organism#GO:0098542;T cell activation involved in immune response#GO:0002286;humoral immune response#GO:0006959;natural killer cell activation#GO:0030101;leukocyte activation involved in immune response#GO:0002366;cell surface receptor signaling pathway#GO:0007166;immune effector process#GO:0002252;B cell activation#GO:0042113 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 interferon superfamily#PC00127;cytokine#PC00083 HUMAN|HGNC=14211|UniProtKB=Q8WV28 Q8WV28 BLNK PTHR14098:SF3 SH2 DOMAIN CONTAINING PROTEIN B-CELL LINKER PROTEIN signaling adaptor activity#GO:0035591;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;immune response-activating cell surface receptor signaling pathway#GO:0002429;signaling#GO:0023052;immune response-regulating signaling pathway#GO:0002764;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;immune system process#GO:0002376;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of immune response#GO:0050776;positive regulation of response to stimulus#GO:0048584;antigen receptor-mediated signaling pathway#GO:0050851;immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007;positive regulation of immune system process#GO:0002684;B cell receptor signaling pathway#GO:0050853;cellular process#GO:0009987;signal transduction#GO:0007165;activation of immune response#GO:0002253;positive regulation of biological process#GO:0048518;immune response-activating signaling pathway#GO:0002757;regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166;positive regulation of immune response#GO:0050778 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 B cell activation#P00010>BLNK#P00394 HUMAN|HGNC=18477|UniProtKB=Q9UKD2 Q9UKD2 MRTO4 PTHR45841:SF2 MRNA TURNOVER PROTEIN 4 MRTO4 MRNA TURNOVER PROTEIN 4 HOMOLOG macromolecule biosynthetic process#GO:0009059;nucleic acid catabolic process#GO:0141188;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;nucleobase-containing compound catabolic process#GO:0034655;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;biosynthetic process#GO:0009058;negative regulation of biosynthetic process#GO:0009890;negative regulation of cellular process#GO:0048523;rRNA metabolic process#GO:0016072;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;rRNA processing#GO:0006364;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;cellular component biogenesis#GO:0044085;RNA processing#GO:0006396;gene expression#GO:0010467;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;ribonucleoprotein complex biogenesis#GO:0022613;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;RNA catabolic process#GO:0006401;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;ribosomal large subunit biogenesis#GO:0042273;RNA metabolic process#GO:0016070 nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;membraneless organelle#GO:0043228;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;intracellular organelle#GO:0043229;preribosome#GO:0030684;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;preribosome, large subunit precursor#GO:0030687 HUMAN|HGNC=30488|UniProtKB=Q6P9A2 Q6P9A2 GALNT18 PTHR11675:SF37 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 18 hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740;acetylgalactosaminyltransferase activity#GO:0008376;glycosyltransferase activity#GO:0016757;catalytic activity, acting on a protein#GO:0140096;UDP-glycosyltransferase activity#GO:0008194;polypeptide N-acetylgalactosaminyltransferase activity#GO:0004653 metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;protein O-linked glycosylation#GO:0006493;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;biosynthetic process#GO:0009058 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 transferase#PC00220;glycosyltransferase#PC00111 HUMAN|HGNC=17072|UniProtKB=Q8IUD2 Q8IUD2 ERC1 PTHR18861:SF1 ELKS/RAB6-INTERACTING/CAST PROTEIN ELKS_RAB6-INTERACTING_CAST FAMILY MEMBER 1 structural molecule activity#GO:0005198;structural constituent of synapse#GO:0098918 cellular component organization#GO:0016043;cellular process#GO:0009987;synapse organization#GO:0050808;cell junction organization#GO:0034330;cellular component organization or biogenesis#GO:0071840 intracellular anatomical structure#GO:0005622;cell junction#GO:0030054;presynaptic active zone#GO:0048786;cytoplasm#GO:0005737;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell cortex#GO:0005938;presynapse#GO:0098793;cell periphery#GO:0071944 membrane traffic protein#PC00150 HUMAN|HGNC=14891|UniProtKB=Q9NXW2 Q9NXW2 DNAJB12 PTHR43908:SF8 AT29763P-RELATED DNAJ HOMOLOG SUBFAMILY B MEMBER 12 protein binding#GO:0005515;Hsp70 protein binding#GO:0030544;binding#GO:0005488;protein-folding chaperone binding#GO:0051087;heat shock protein binding#GO:0031072 cellular response to misfolded protein#GO:0071218;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;response to stress#GO:0006950;biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467;cellular response to stress#GO:0033554;cellular response to topologically incorrect protein#GO:0035967;protein metabolic process#GO:0019538;cellular response to stimulus#GO:0051716;response to misfolded protein#GO:0051788;primary metabolic process#GO:0044238;response to topologically incorrect protein#GO:0035966;protein folding#GO:0006457;response to stimulus#GO:0050896 endoplasmic reticulum membrane#GO:0005789;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=8349|UniProtKB=Q8NHB7 Q8NHB7 OR5K1 PTHR26452:SF829 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5K1 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 sensory perception#GO:0007600;nervous system process#GO:0050877;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=30180|UniProtKB=Q8WUB2 Q8WUB2 FAM216A PTHR16476:SF1 FAMILY WITH SEQUENCE SIMILARITY 216 MEMBER A PROTEIN FAM216A HUMAN|HGNC=23673|UniProtKB=Q7Z304 Q7Z304 MAMDC2 PTHR23282:SF116 APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR. MAM DOMAIN-CONTAINING PROTEIN 2 HUMAN|HGNC=20062|UniProtKB=Q9P275 Q9P275 USP36 PTHR24006:SF653 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 36 deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787;cysteine-type deubiquitinase activity#GO:0004843;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233 regulation of apoptotic process#GO:0042981;regulation of biological process#GO:0050789;regulation of protein stability#GO:0031647;regulation of programmed cell death#GO:0043067;regulation of biological quality#GO:0065008;biological regulation#GO:0065007;regulation of cellular process#GO:0050794 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 cysteine protease#PC00081;protease#PC00190 HUMAN|HGNC=18317|UniProtKB=Q9BSH3 Q9BSH3 NICN1 PTHR31239:SF4 NICOLIN 1 NICOLIN-1 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=14668|UniProtKB=Q495T6 Q495T6 MMEL1 PTHR11733:SF141 ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED MEMBRANE METALLO-ENDOPEPTIDASE-LIKE 1 catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222 biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604;protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;proteolysis#GO:0006508;metabolic process#GO:0008152 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 protease#PC00190;metalloprotease#PC00153 HUMAN|HGNC=13205|UniProtKB=Q9C0K7 Q9C0K7 STRADB PTHR48014:SF13 SERINE/THREONINE-PROTEIN KINASE FRAY2 STE20-RELATED KINASE ADAPTER PROTEIN BETA kinase activator activity#GO:0019209;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;protein serine/threonine kinase activator activity#GO:0043539;enzyme activator activity#GO:0008047;protein kinase activator activity#GO:0030295;protein kinase regulator activity#GO:0019887;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772 nucleocytoplasmic transport#GO:0006913;localization#GO:0051179;cellular localization#GO:0051641;nuclear transport#GO:0051169;nuclear export#GO:0051168;protein transport#GO:0015031;intracellular transport#GO:0046907;transport#GO:0006810;intracellular protein transport#GO:0006886;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;protein export from nucleus#GO:0006611 protein-containing complex#GO:0032991;protein kinase complex#GO:1902911;serine/threonine protein kinase complex#GO:1902554;transferase complex, transferring phosphorus-containing groups#GO:0061695;transferase complex#GO:1990234;catalytic complex#GO:1902494 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=11879|UniProtKB=P63313 P63313 TMSB10 PTHR12021:SF10 THYMOSIN BETA THYMOSIN BETA-10 protein binding#GO:0005515;binding#GO:0005488;molecular sequestering activity#GO:0140313;actin monomer binding#GO:0003785;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;protein sequestering activity#GO:0140311 regulation of cellular process#GO:0050794;regulation of cell motility#GO:2000145;regulation of locomotion#GO:0040012;biological regulation#GO:0065007;regulation of cell migration#GO:0030334;regulation of biological process#GO:0050789 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=29849|UniProtKB=Q8N3J6 Q8N3J6 CADM2 PTHR45889:SF1 IG-LIKE DOMAIN-CONTAINING PROTEIN CELL ADHESION MOLECULE 2 cell adhesion#GO:0007155;cellular process#GO:0009987;homophilic cell-cell adhesion#GO:0007156;cell-cell adhesion#GO:0098609 membrane#GO:0016020;cell body#GO:0044297;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;neuronal cell body#GO:0043025;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477 HUMAN|HGNC=5457|UniProtKB=Q12894 Q12894 IFRD2 PTHR12354:SF8 INTERFERON-RELATED DEVELOPMENTAL REGULATOR INTERFERON-RELATED DEVELOPMENTAL REGULATOR 2 HUMAN|HGNC=24538|UniProtKB=Q9BUJ0 Q9BUJ0 ABHD14A PTHR46197:SF1 PROTEIN ABHD14B-LIKE PROTEIN ABHD14A intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=28566|UniProtKB=Q8IYX7 Q8IYX7 SAXO1 PTHR31516:SF9 STABILIZER OF AXONEMAL MICROTUBULES 2 STABILIZER OF AXONEMAL MICROTUBULES 1 tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;microtubule binding#GO:0008017;protein binding#GO:0005515 membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cytoskeleton#GO:0005856;ciliary basal body#GO:0036064;microtubule organizing center#GO:0005815;supramolecular polymer#GO:0099081;sperm flagellum#GO:0036126;ciliary plasm#GO:0097014;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;centriole#GO:0005814;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;axoneme#GO:0005930;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membrane-bounded organelle#GO:0043227;cilium#GO:0005929;9+2 motile cilium#GO:0097729;intracellular organelle#GO:0043229;axonemal microtubule#GO:0005879;cellular anatomical structure#GO:0110165;motile cilium#GO:0031514;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cytoplasmic microtubule#GO:0005881 non-motor microtubule binding protein#PC00166;cytoskeletal protein#PC00085 HUMAN|HGNC=2956|UniProtKB=P24855 P24855 DNASE1 PTHR11371:SF27 DEOXYRIBONUCLEASE DEOXYRIBONUCLEASE-1 nuclease activity#GO:0004518;hydrolase activity#GO:0016787;DNA endonuclease activity#GO:0004520;DNA binding#GO:0003677;binding#GO:0005488;nucleic acid binding#GO:0003676;endonuclease activity#GO:0004519;catalytic activity, acting on DNA#GO:0140097;DNA nuclease activity#GO:0004536;hydrolase activity, acting on ester bonds#GO:0016788;DNA endonuclease activity, producing 5'-phosphomonoesters#GO:0016888;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 DNA metabolic process#GO:0006259;macromolecule catabolic process#GO:0009057;DNA catabolic process#GO:0006308;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;nucleobase-containing compound catabolic process#GO:0034655;cellular process#GO:0009987;nucleic acid catabolic process#GO:0141188;catabolic process#GO:0009056;nucleobase-containing compound metabolic process#GO:0006139 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 endodeoxyribonuclease#PC00093 HUMAN|HGNC=26831|UniProtKB=Q8N4C9 Q8N4C9 C17orf78 PTHR36870:SF1 C17ORF78 ISOFORM 2 SIMILAR TO HUMAN CHROMOSOME 17 OPEN READING FRAME 78 HUMAN|HGNC=25642|UniProtKB=Q5VWQ0 Q5VWQ0 RSBN1 PTHR13354:SF8 ROUND SPERMATID BASIC PROTEIN 1 LYSINE-SPECIFIC DEMETHYLASE 9 histone modifying activity#GO:0140993;dioxygenase activity#GO:0051213;oxidoreductase activity#GO:0016491;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;demethylase activity#GO:0032451;catalytic activity, acting on a protein#GO:0140096;protein demethylase activity#GO:0140457;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;histone demethylase activity#GO:0032452;catalytic activity#GO:0003824 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=6596|UniProtKB=P15018 P15018 LIF PTHR10633:SF0 LEUKEMIA INHIBITORY FACTOR LEUKEMIA INHIBITORY FACTOR signaling receptor regulator activity#GO:0030545;growth factor activity#GO:0008083;receptor ligand activity#GO:0048018;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;cytokine receptor binding#GO:0005126;binding#GO:0005488;signaling receptor binding#GO:0005102;cytokine activity#GO:0005125;molecular function activator activity#GO:0140677;protein binding#GO:0005515 cell surface receptor signaling pathway#GO:0007166;regulation of cell differentiation#GO:0045595;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;biological regulation#GO:0065007;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;positive regulation of cell population proliferation#GO:0008284;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;regulation of developmental process#GO:0050793 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 cytokine#PC00083;intercellular signal molecule#PC00207 HUMAN|HGNC=5474|UniProtKB=P24593 P24593 IGFBP5 PTHR11551:SF4 INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 5 protein binding#GO:0005515;growth factor binding#GO:0019838;binding#GO:0005488 regulation of biological process#GO:0050789;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cell communication#GO:0010646 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protein-binding activity modulator#PC00095;protease inhibitor#PC00191 HUMAN|HGNC=3493|UniProtKB=P43268 P43268 ETV4 PTHR11849:SF181 ETS ETS TRANSLOCATION VARIANT 4 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;developmental process#GO:0032502 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;winged helix/forkhead transcription factor#PC00246 HUMAN|HGNC=20493|UniProtKB=Q86TU7 Q86TU7 SETD3 PTHR13271:SF159 UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE ACTIN-HISTIDINE N-METHYLTRANSFERASE methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;protein-lysine N-methyltransferase activity#GO:0016279;N-methyltransferase activity#GO:0008170;lysine N-methyltransferase activity#GO:0016278;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring one-carbon groups#GO:0016741;protein methyltransferase activity#GO:0008276;catalytic activity, acting on a protein#GO:0140096 biological regulation#GO:0065007;regulation of smooth muscle contraction#GO:0006940;regulation of multicellular organismal process#GO:0051239;regulation of biological process#GO:0050789;regulation of muscle system process#GO:0090257;regulation of muscle contraction#GO:0006937;regulation of system process#GO:0044057 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 methyltransferase#PC00155;transferase#PC00220 HUMAN|HGNC=52390|UniProtKB=A0A1B0GVK7 A0A1B0GVK7 FAM240A PTHR40387:SF3 PROTEIN FAM240B PROTEIN FAM240A HUMAN|HGNC=1581|UniProtKB=P24863 P24863 CCNC PTHR10026:SF7 CYCLIN CYCLIN-C protein kinase regulator activity#GO:0019887;cyclin-dependent protein kinase regulator activity#GO:0019914;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;enzyme regulator activity#GO:0030234;cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538 positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893 nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mediator complex#GO:0016592 kinase activator#PC00138;kinase modulator#PC00140 HUMAN|HGNC=20863|UniProtKB=P0CK97 P0CK97 SLC35E2A PTHR11132:SF521 SOLUTE CARRIER FAMILY 35 SOLUTE CARRIER FAMILY 35 MEMBER E2A-RELATED transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;secondary active transmembrane transporter activity#GO:0015291;antiporter activity#GO:0015297;active transmembrane transporter activity#GO:0022804 transport#GO:0006810;cellular process#GO:0009987;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234 membrane#GO:0016020;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227 transporter#PC00227;secondary carrier transporter#PC00258 HUMAN|HGNC=18933|UniProtKB=Q3LI67 Q3LI67 KRTAP6-3 PTHR31678:SF6 KERATIN-ASSOCIATED PROTEIN 6-3 KERATIN-ASSOCIATED PROTEIN 6-3 structural protein#PC00211 HUMAN|HGNC=24012|UniProtKB=Q9BRS8 Q9BRS8 LARP6 PTHR22792:SF71 LUPUS LA PROTEIN-RELATED LA-RELATED PROTEIN 6 mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031 HUMAN|HGNC=28532|UniProtKB=Q8IV33 Q8IV33 KIAA0825 PTHR33960:SF1 SIMILAR TO KIAA0825 PROTEIN KIAA0825 HOMOLOG HUMAN|HGNC=16345|UniProtKB=Q8N109 Q8N109 KIR2DL5A PTHR11738:SF113 MHC CLASS I NK CELL RECEPTOR KILLER CELL IMMUNOGLOBULIN-LIKE RECEPTOR 2DL5A-RELATED transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;immune receptor activity#GO:0140375;signaling receptor activity#GO:0038023 cell communication#GO:0007154;regulation of immune response#GO:0050776;regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166;response to stimulus#GO:0050896;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;immune response-regulating signaling pathway#GO:0002764 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=28689|UniProtKB=Q8N4M1 Q8N4M1 SLC44A3 PTHR12385:SF13 CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44) CHOLINE TRANSPORTER-LIKE PROTEIN 3 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 transport#GO:0006810;cellular process#GO:0009987;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085 cellular anatomical structure#GO:0110165;membrane#GO:0016020 transporter#PC00227;secondary carrier transporter#PC00258 Nicotinic acetylcholine receptor signaling pathway#P00044>CHT1#P01098 HUMAN|HGNC=7696|UniProtKB=O96000 O96000 NDUFB10 PTHR13094:SF1 NADH-UBIQUINONE OXIDOREDUCTASE PDSW SUBUNIT NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 10 transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;catalytic complex#GO:1902494;respiratory chain complex I#GO:0045271;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;membrane protein complex#GO:0098796;membrane#GO:0016020;oxidoreductase complex#GO:1990204;respiratory chain complex#GO:0098803 oxidoreductase#PC00176 HUMAN|HGNC=7989|UniProtKB=P01111 P01111 NRAS PTHR24070:SF189 RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY GTPASE NRAS hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides#GO:0016817 regulation of cell population proliferation#GO:0042127;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;Ras protein signal transduction#GO:0007265;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;positive regulation of cell population proliferation#GO:0008284;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;intracellular signaling cassette#GO:0141124;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 small GTPase#PC00208 TGF-beta signaling pathway#P00052>Ras-GDP#P01291;PDGF signaling pathway#P00047>Ras#P01154;EGF receptor signaling pathway#P00018>Ras#P00552;Ras Pathway#P04393>Ras#P04547;Integrin signalling pathway#P00034>Ras#P00916;TGF-beta signaling pathway#P00052>Ras-GTP#P01280;VEGF signaling pathway#P00056>Ras#P01411;PI3 kinase pathway#P00048>Ras#P01182;B cell activation#P00010>Ras#P00376;Angiogenesis#P00005>Ras#P00238;p53 pathway feedback loops 2#P04398>Ras#P04651;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Ras#P00869;FGF signaling pathway#P00021>Ras#P00633;Interleukin signaling pathway#P00036>Ras#P00977;T cell activation#P00053>Ras#P01306 HUMAN|HGNC=10430|UniProtKB=Q15418 Q15418 RPS6KA1 PTHR24351:SF43 RIBOSOMAL PROTEIN S6 KINASE RIBOSOMAL PROTEIN S6 KINASE ALPHA-1 catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;TOR signaling#GO:0031929;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;cell communication#GO:0007154;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;TORC1 signaling#GO:0038202;regulation of RNA metabolic process#GO:0051252;intracellular signal transduction#GO:0035556;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;response to stimulus#GO:0050896;positive regulation of RNA metabolic process#GO:0051254;signaling#GO:0023052 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654 protein modifying enzyme#PC00260 CCKR signaling map#P06959>RSK1/2#P07153;PDGF signaling pathway#P00047>p90RSK#P01142;Ras Pathway#P04393>p90RSK#P04541;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>P90 RSK#P00888;Interleukin signaling pathway#P00036>p90RSK#P00964 HUMAN|HGNC=14074|UniProtKB=Q9NZ56 Q9NZ56 FMN2 PTHR13037:SF16 FORMIN FORMIN-2 protein binding#GO:0005515;microtubule binding#GO:0008017;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;tubulin binding#GO:0015631 organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;actin filament bundle assembly#GO:0051017;actin filament bundle organization#GO:0061572;cellular process#GO:0009987;cellular component assembly#GO:0022607;actin cytoskeleton organization#GO:0030036;cytoskeleton organization#GO:0007010;actin filament-based process#GO:0030029;cellular component organization or biogenesis#GO:0071840;actin filament organization#GO:0007015;supramolecular fiber organization#GO:0097435 endomembrane system#GO:0012505;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630;membrane#GO:0016020;nucleus#GO:0005634;membraneless organelle#GO:0043228;organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;cytoskeleton#GO:0005856;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229 HUMAN|HGNC=18431|UniProtKB=P49753 P49753 ACOT2 PTHR10824:SF44 ACYL-COENZYME A THIOESTERASE-RELATED ACYL-COENZYME A THIOESTERASE 1-RELATED hydrolase activity#GO:0016787;deacylase activity#GO:0160215;catalytic activity#GO:0003824;acyl-CoA hydrolase activity#GO:0016289;fatty acyl-CoA hydrolase activity#GO:0047617;hydrolase activity, acting on ester bonds#GO:0016788;thiolester hydrolase activity#GO:0016790 cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;long-chain fatty acid metabolic process#GO:0001676;sulfur compound metabolic process#GO:0006790;nucleobase-containing compound metabolic process#GO:0006139;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;acyl-CoA metabolic process#GO:0006637;nucleobase-containing small molecule metabolic process#GO:0055086;purine-containing compound metabolic process#GO:0072521;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;very long-chain fatty acid metabolic process#GO:0000038;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;oxoacid metabolic process#GO:0043436 peroxisome#GO:0005777;microbody#GO:0042579;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 esterase#PC00097 HUMAN|HGNC=1109|UniProtKB=O95415 O95415 BRI3 PTHR13551:SF1 BRAIN PROTEIN I3 MEMBRANE PROTEIN BRI3 HUMAN|HGNC=11459|UniProtKB=O00204 O00204 SULT2B1 PTHR11783:SF9 SULFOTRANSFERASE SULT SULFOTRANSFERASE 2B1 transferase activity, transferring sulphur-containing groups#GO:0016782;sulfotransferase activity#GO:0008146;catalytic activity#GO:0003824;transferase activity#GO:0016740 metabolic process#GO:0008152;sulfur compound metabolic process#GO:0006790;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 transferase#PC00220;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=14188|UniProtKB=O75366 O75366 AVIL PTHR11977:SF33 VILLIN ADVILLIN phosphatidylinositol phosphate binding#GO:1901981;cytoskeletal protein binding#GO:0008092;phospholipid binding#GO:0005543;protein-containing complex binding#GO:0044877;lipid binding#GO:0008289;protein binding#GO:0005515;phosphatidylinositol bisphosphate binding#GO:1902936;actin binding#GO:0003779;actin filament binding#GO:0051015;small molecule binding#GO:0036094;anion binding#GO:0043168;binding#GO:0005488;ion binding#GO:0043167;phosphatidylinositol-4,5-bisphosphate binding#GO:0005546 negative regulation of actin filament depolymerization#GO:0030835;regulation of biological quality#GO:0065008;regulation of actin filament length#GO:0030832;regulation of cellular component organization#GO:0051128;negative regulation of actin filament polymerization#GO:0030837;regulation of cellular component biogenesis#GO:0044087;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;regulation of protein-containing complex assembly#GO:0043254;regulation of biological process#GO:0050789;regulation of cellular component size#GO:0032535;regulation of organelle organization#GO:0033043;cellular component organization or biogenesis#GO:0071840;regulation of anatomical structure size#GO:0090066;cytoskeleton organization#GO:0007010;regulation of actin cytoskeleton organization#GO:0032956;regulation of protein-containing complex disassembly#GO:0043244;organelle organization#GO:0006996;cellular process#GO:0009987;negative regulation of cytoskeleton organization#GO:0051494;negative regulation of protein-containing complex disassembly#GO:0043242;negative regulation of protein-containing complex assembly#GO:0031333;supramolecular fiber organization#GO:0097435;negative regulation of protein polymerization#GO:0032272;actin filament capping#GO:0051693;actin filament-based process#GO:0030029;regulation of protein polymerization#GO:0032271;regulation of cytoskeleton organization#GO:0051493;negative regulation of supramolecular fiber organization#GO:1902904;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;regulation of actin filament depolymerization#GO:0030834;negative regulation of organelle organization#GO:0010639;negative regulation of cellular component organization#GO:0051129;regulation of supramolecular fiber organization#GO:1902903;actin filament organization#GO:0007015;regulation of protein depolymerization#GO:1901879;regulation of actin filament-based process#GO:0032970;negative regulation of cellular process#GO:0048523;regulation of actin filament polymerization#GO:0030833;regulation of actin polymerization or depolymerization#GO:0008064;biological regulation#GO:0065007;negative regulation of protein depolymerization#GO:1901880;actin polymerization or depolymerization#GO:0008154;regulation of actin filament organization#GO:0110053 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;actin cytoskeleton#GO:0015629 non-motor actin binding protein#PC00165;actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=1300|UniProtKB=P58505 P58505 C21orf58 PTHR28604:SF2 FAMILY NOT NAMED RIKEN CDNA 2610028H24 GENE HUMAN|HGNC=14323|UniProtKB=Q9NZQ8 Q9NZQ8 TRPM5 PTHR13800:SF5 TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6 TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 5 calcium-activated cation channel activity#GO:0005227;channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation channel activity#GO:0005261;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;monoatomic ion-gated channel activity#GO:0022839;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;ligand-gated monoatomic cation channel activity#GO:0099094;ligand-gated calcium channel activity#GO:0099604;calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;gated channel activity#GO:0022836;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873;transporter activity#GO:0005215 monoatomic ion transport#GO:0006811;calcium ion transport#GO:0006816;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;monoatomic cation transport#GO:0006812;transport#GO:0006810;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;cellular process#GO:0009987;calcium ion transmembrane transport#GO:0070588 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=13588|UniProtKB=Q9UK97 Q9UK97 FBXO9 PTHR12874:SF29 F-BOX ONLY PROTEIN 48-RELATED F-BOX ONLY PROTEIN 9 ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;metabolic process#GO:0008152;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;SCF ubiquitin ligase complex#GO:0019005;cullin-RING ubiquitin ligase complex#GO:0031461;catalytic complex#GO:1902494;transferase complex#GO:1990234;ubiquitin ligase complex#GO:0000151;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535 HUMAN|HGNC=13347|UniProtKB=Q9BS40 Q9BS40 LXN PTHR28591:SF1 LATEXIN LATEXIN enzyme inhibitor activity#GO:0004857;endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;peptidase regulator activity#GO:0061134;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HUMAN|HGNC=23618|UniProtKB=Q6NV75 Q6NV75 GPR153 PTHR16518:SF5 G-PROTEIN COUPLED RECEPTOR 153, 162 G PROTEIN-COUPLED RECEPTOR 153-RELATED transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=7985|UniProtKB=Q15406 Q15406 NR6A1 PTHR48092:SF18 KNIRPS-RELATED PROTEIN-RELATED NUCLEAR RECEPTOR SUBFAMILY 6 GROUP A MEMBER 1 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;molecular transducer activity#GO:0060089;DNA binding#GO:0003677;nuclear receptor activity#GO:0004879;sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023;transcription regulator activity#GO:0140110;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulatory region nucleic acid binding#GO:0001067 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 chromosome#GO:0005694;nucleus#GO:0005634;chromatin#GO:0000785;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 zinc finger transcription factor#PC00244;C4 zinc finger nuclear receptor#PC00169 HUMAN|HGNC=9649|UniProtKB=Q99952 Q99952 PTPN18 PTHR45983:SF4 TYROSINE PHOSPHATSE N18, PUTATIVE-RELATED TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 18 catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=28954|UniProtKB=Q96BP3 Q96BP3 PPWD1 PTHR45625:SF4 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1 catalytic activity#GO:0003824;cis-trans isomerase activity#GO:0016859;peptidyl-prolyl cis-trans isomerase activity#GO:0003755;isomerase activity#GO:0016853;catalytic activity, acting on a protein#GO:0140096 chaperone#PC00072 HUMAN|HGNC=25894|UniProtKB=Q96K75 Q96K75 ZNF514 PTHR24377:SF908 IP01015P-RELATED ZINC FINGER PROTEIN 514 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=13606|UniProtKB=Q9Y2K7 Q9Y2K7 KDM2A PTHR23123:SF3 PHD/F-BOX CONTAINING PROTEIN LYSINE-SPECIFIC DEMETHYLASE 2A catalytic activity#GO:0003824;histone demethylase activity#GO:0032452;demethylase activity#GO:0032451;catalytic activity, acting on a protein#GO:0140096;protein demethylase activity#GO:0140457;histone modifying activity#GO:0140993 cellular process#GO:0009987;cellular component organization#GO:0016043;chromatin organization#GO:0006325;chromatin remodeling#GO:0006338;cellular component organization or biogenesis#GO:0071840 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 chromatin/chromatin-binding, or -regulatory protein#PC00077;histone modifying enzyme#PC00261 HUMAN|HGNC=20529|UniProtKB=P59990 P59990 KRTAP12-1 PTHR23262:SF180 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 12-1-RELATED structural protein#PC00211 HUMAN|HGNC=18697|UniProtKB=Q8N3C0 Q8N3C0 ASCC3 PTHR24075:SF6 SEC63 DOMAIN-CONTAINING ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3 RNA binding#GO:0003723;ATP-dependent activity, acting on DNA#GO:0008094;ATP-dependent activity#GO:0140657;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA helicase activity#GO:0003678;3'-5' DNA helicase activity#GO:0043138;isomerase activity#GO:0016853;catalytic activity, acting on DNA#GO:0140097;helicase activity#GO:0004386;macromolecular conformation isomerase activity#GO:0120543;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity#GO:0003824 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 scaffold/adaptor protein#PC00226 HUMAN|HGNC=6327|UniProtKB=O60870 O60870 KIN PTHR12805:SF0 KIN17 KIN, ANTIGENIC DETERMINANT OF RECA PROTEIN HOMOLOG DNA_RNA-BINDING PROTEIN KIN17 nucleic acid binding#GO:0003676;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677 response to stress#GO:0006950;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;DNA damage response#GO:0006974;cellular response to stress#GO:0033554;response to stimulus#GO:0050896 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=12195|UniProtKB=A0A1B0GX68 A0A1B0GX68 TRBV2 PTHR23268:SF45 T-CELL RECEPTOR BETA CHAIN T CELL RECEPTOR BETA VARIABLE 2 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=33186|UniProtKB=Q6ZNG2 Q6ZNG2 DBX2 PTHR24331:SF4 DBX HOMEOBOX PROTEIN DBX2 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 HUMAN|HGNC=25745|UniProtKB=Q9H9L3 Q9H9L3 ISG20L2 PTHR12801:SF78 RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED INTERFERON-STIMULATED 20 KDA EXONUCLEASE-LIKE 2 hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;exonuclease activity#GO:0004527;catalytic activity, acting on a nucleic acid#GO:0140640;nuclease activity#GO:0004518;hydrolase activity#GO:0016787 nucleic acid biosynthetic process#GO:0141187;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;gene expression#GO:0010467 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 exoribonuclease#PC00099;RNA metabolism protein#PC00031 HUMAN|HGNC=15079|UniProtKB=Q6IEY1 Q6IEY1 OR4F3 PTHR48002:SF1 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 4F21-RELATED molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=9519|UniProtKB=P11465 P11465 PSG2 PTHR44337:SF15 CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 8 PREGNANCY-SPECIFIC BETA-1-GLYCOPROTEIN 11-RELATED cellular process#GO:0009987;heterophilic cell-cell adhesion#GO:0007157;cell adhesion#GO:0007155;cell-cell adhesion#GO:0098609;homophilic cell-cell adhesion#GO:0007156 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 immunoglobulin superfamily cell adhesion molecule#PC00125;cell adhesion molecule#PC00069 HUMAN|HGNC=29685|UniProtKB=Q9NSE4 Q9NSE4 IARS2 PTHR42765:SF3 SOLEUCYL-TRNA SYNTHETASE ISOLEUCINE--TRNA LIGASE, MITOCHONDRIAL catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;ligase activity#GO:0016874 tRNA aminoacylation#GO:0043039;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;tRNA aminoacylation for protein translation#GO:0006418;gene expression#GO:0010467;amino acid metabolic process#GO:0006520;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;amino acid activation#GO:0043038;macromolecule metabolic process#GO:0043170;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mitochondrial translation#GO:0032543;protein biosynthetic process#GO:0160307;translation#GO:0006412;RNA metabolic process#GO:0016070;protein metabolic process#GO:0019538;mitochondrial gene expression#GO:0140053 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cytosol#GO:0005829;mitochondrion#GO:0005739 translational protein#PC00263;aminoacyl-tRNA synthetase#PC00047 HUMAN|HGNC=19411|UniProtKB=Q86VH4 Q86VH4 LRRTM4 PTHR24373:SF283 SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN LEUCINE-RICH REPEAT TRANSMEMBRANE NEURONAL PROTEIN 4 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=21045|UniProtKB=Q9UKF7 Q9UKF7 PITPNC1 PTHR10658:SF55 PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CYTOPLASMIC PHOSPHATIDYLINOSITOL TRANSFER PROTEIN 1 intramembrane lipid carrier activity#GO:0140303;cation binding#GO:0043169;anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167;phosphatidylcholine intramembrane carrier activity#GO:0008525;lipid carrier activity#GO:0005319;phosphatidylcholine binding#GO:0031210;phosphatidylinositol transfer activity#GO:0008526;phosphatidylinositol binding#GO:0035091;phospholipid binding#GO:0005543;lipid transfer activity#GO:0120013;lipid binding#GO:0008289;binding#GO:0005488;molecular carrier activity#GO:0140104;transporter activity#GO:0005215 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 transporter#PC00227 HUMAN|HGNC=11336|UniProtKB=Q16385 Q16385 SSX2 PTHR14112:SF5 SYNOVIAL SARCOMA, X MEMBER PROTEIN SSX2-RELATED nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HUMAN|HGNC=4662|UniProtKB=Q92664 Q92664 GTF3A PTHR46179:SF1 ZINC FINGER PROTEIN TRANSCRIPTION FACTOR IIIA regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218 HUMAN|HGNC=16926|UniProtKB=Q9BYQ4 Q9BYQ4 KRTAP9-2 PTHR23262:SF32 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 9-2-RELATED structural protein#PC00211 HUMAN|HGNC=3681|UniProtKB=P11487 P11487 FGF3 PTHR11486:SF26 FIBROBLAST GROWTH FACTOR FIBROBLAST GROWTH FACTOR 3 fibroblast growth factor receptor binding#GO:0005104;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;growth factor activity#GO:0008083;growth factor receptor binding#GO:0070851;protein binding#GO:0005515;molecular function activator activity#GO:0140677;signaling receptor binding#GO:0005102;binding#GO:0005488 regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;positive regulation of cell population proliferation#GO:0008284;signaling#GO:0023052;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;cell differentiation#GO:0030154;regulation of signaling#GO:0023051;animal gross anatomical part developmental process#GO:0160108;regulation of intracellular signal transduction#GO:1902531;cellular response to growth factor stimulus#GO:0071363;positive regulation of signaling#GO:0023056;cellular response to fibroblast growth factor stimulus#GO:0044344;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;nervous system development#GO:0007399;cell surface receptor signaling pathway#GO:0007166;regulation of MAPK cascade#GO:0043408;multicellular organism development#GO:0007275;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;response to growth factor#GO:0070848;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;system development#GO:0048731;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;regulation of cell population proliferation#GO:0042127;cell communication#GO:0007154;regulation of cell motility#GO:2000145;positive regulation of cellular process#GO:0048522;regulation of locomotion#GO:0040012;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;fibroblast growth factor receptor signaling pathway#GO:0008543;positive regulation of response to stimulus#GO:0048584;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;regulation of cell migration#GO:0030334;developmental process#GO:0032502;response to fibroblast growth factor#GO:0071774;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;positive regulation of MAPK cascade#GO:0043410 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207;growth factor#PC00112 FGF signaling pathway#P00021>FGF#P00623 HUMAN|HGNC=17896|UniProtKB=Q9UMS4 Q9UMS4 PRPF19 PTHR43995:SF1 PRE-MRNA-PROCESSING FACTOR 19 PRE-MRNA-PROCESSING FACTOR 19 aminoacyltransferase activity#GO:0016755;ubiquitin-protein transferase activity#GO:0004842;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398 organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;U2-type spliceosomal complex#GO:0005684;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;spliceosomal complex#GO:0005681;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;Prp19 complex#GO:0000974;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 RNA processing factor#PC00147;RNA metabolism protein#PC00031 mRNA splicing#P00058>U4#P01476 HUMAN|HGNC=25140|UniProtKB=O95562 O95562 SFT2D2 PTHR23137:SF1 VESICLE TRANSPORT PROTEIN-RELATED VESICLE TRANSPORT PROTEIN SFT2B HUMAN|HGNC=84|UniProtKB=Q13085 Q13085 ACACA PTHR45728:SF5 ACETYL-COA CARBOXYLASE, ISOFORM A ACETYL-COA CARBOXYLASE 1 catalytic activity#GO:0003824;ligase activity#GO:0016874 oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;monocarboxylic acid biosynthetic process#GO:0072330;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;carboxylic acid biosynthetic process#GO:0046394;cellular process#GO:0009987;small molecule metabolic process#GO:0044281;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058;fatty acid biosynthetic process#GO:0006633 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739 HUMAN|HGNC=15999|UniProtKB=Q9NZV5 Q9NZV5 SELENON PTHR16213:SF78 SELENOPROTEIN N SELENOPROTEIN N muscle organ development#GO:0007517;striated muscle tissue development#GO:0014706;chemical homeostasis#GO:0048878;animal organ development#GO:0048513;regulation of localization#GO:0032879;regulation of transport#GO:0051049;striated muscle cell differentiation#GO:0051146;regulation of release of sequestered calcium ion into cytosol#GO:0051279;monoatomic ion homeostasis#GO:0050801;regulation of monoatomic ion transmembrane transport#GO:0034765;cellular process#GO:0009987;animal gross anatomical part developmental process#GO:0160108;skeletal muscle organ development#GO:0060538;calcium ion homeostasis#GO:0055074;inorganic ion homeostasis#GO:0098771;striated muscle cell development#GO:0055002;regulation of biological process#GO:0050789;cell differentiation#GO:0030154;cell development#GO:0048468;regulation of monoatomic cation transmembrane transport#GO:1904062;developmental process#GO:0032502;monoatomic cation homeostasis#GO:0055080;cellular developmental process#GO:0048869;skeletal muscle tissue development#GO:0007519;regulation of monoatomic ion transport#GO:0043269;tissue development#GO:0009888;regulation of calcium ion transport#GO:0051924;biological regulation#GO:0065007;anatomical structure development#GO:0048856;muscle tissue development#GO:0060537;muscle cell development#GO:0055001;regulation of transmembrane transport#GO:0034762;muscle cell differentiation#GO:0042692;regulation of metal ion transport#GO:0010959;regulation of cellular process#GO:0050794;muscle structure development#GO:0061061;homeostatic process#GO:0042592 endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226 HUMAN|HGNC=10364|UniProtKB=P62424 P62424 RPL7A PTHR23105:SF189 RIBOSOMAL PROTEIN L7AE FAMILY MEMBER LARGE RIBOSOMAL SUBUNIT PROTEIN EL8 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;maturation of LSU-rRNA#GO:0000470;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;ribosomal large subunit biogenesis#GO:0042273;ribosome biogenesis#GO:0042254;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 ribosome#GO:0005840;cytosol#GO:0005829;cytosolic large ribosomal subunit#GO:0022625;cytosolic ribosome#GO:0022626;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 translational protein#PC00263;ribosomal protein#PC00202 HUMAN|HGNC=13233|UniProtKB=P39687 P39687 ANP32A PTHR11375:SF1 ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32 ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32 FAMILY MEMBER A histone binding#GO:0042393;binding#GO:0005488;protein binding#GO:0005515 establishment of localization in cell#GO:0051649;regulation of biological process#GO:0050789;cellular process#GO:0009987;regulation of programmed cell death#GO:0043067;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of apoptotic process#GO:0042981;nucleocytoplasmic transport#GO:0006913;transport#GO:0006810;intracellular transport#GO:0046907;nuclear transport#GO:0051169;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;perinuclear region of cytoplasm#GO:0048471;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=25420|UniProtKB=Q9H0X6 Q9H0X6 RNF208 PTHR22791:SF3 RING-TYPE DOMAIN-CONTAINING PROTEIN E3 UBIQUITIN-PROTEIN LIGASE RNF182-RELATED ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;cellular process#GO:0009987;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=10890|UniProtKB=Q9UIU6 Q9UIU6 SIX4 PTHR10390:SF36 HOMEOBOX PROTEIN SIX HOMEOBOX PROTEIN SIX4 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119 HUMAN|HGNC=4831|UniProtKB=P69891 P69891 HBG1 PTHR11442:SF94 HEMOGLOBIN FAMILY MEMBER HEMOGLOBIN SUBUNIT GAMMA-1 tetrapyrrole binding#GO:0046906;protein binding#GO:0005515;heme binding#GO:0020037;binding#GO:0005488;molecular carrier activity#GO:0140104 cellular developmental process#GO:0048869;establishment of localization#GO:0051234;multicellular organismal-level homeostasis#GO:0048871;developmental process#GO:0032502;transport#GO:0006810;multicellular organismal process#GO:0032501;hemopoiesis#GO:0030097;cellular process#GO:0009987;localization#GO:0051179;anatomical structure development#GO:0048856;erythrocyte differentiation#GO:0030218;immune system process#GO:0002376;homeostasis of number of cells#GO:0048872;cell differentiation#GO:0030154;myeloid cell differentiation#GO:0030099;homeostatic process#GO:0042592;cell development#GO:0048468 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 globin#PC00107;transfer/carrier protein#PC00219 HUMAN|Ensembl=ENSG00000262505.2|UniProtKB=A0A0G2JLG4 A0A0G2JLG4 ASIC5 PTHR11690:SF286 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED BILE ACID-SENSITIVE ION CHANNEL ligand-gated monoatomic cation channel activity#GO:0099094;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;sodium channel activity#GO:0005272;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;monoatomic cation channel activity#GO:0005261;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267 monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transport#GO:0006811;transport#GO:0006810;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;monoatomic ion transmembrane transport#GO:0034220;sodium ion transmembrane transport#GO:0035725;sodium ion transport#GO:0006814;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=24310|UniProtKB=Q53GL0 Q53GL0 PLEKHO1 PTHR15871:SF1 PH DOMAIN-CONTAINING PROTEIN PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY O MEMBER 1 biological regulation#GO:0065007;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789 leading edge membrane#GO:0031256;ruffle membrane#GO:0032587;cell projection membrane#GO:0031253;ruffle#GO:0001726;cell periphery#GO:0071944;cell leading edge#GO:0031252;membrane#GO:0016020;cell projection#GO:0042995;plasma membrane#GO:0005886;plasma membrane bounded cell projection#GO:0120025;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165 HUMAN|HGNC=12724|UniProtKB=P04004 P04004 VTN PTHR22917:SF3 HEMOPEXIN DOMAIN-CONTAINING PROTEIN VITRONECTIN protein-containing complex binding#GO:0044877;integrin binding#GO:0005178;protein binding#GO:0005515;extracellular matrix binding#GO:0050840;cell adhesion molecule binding#GO:0050839;signaling receptor binding#GO:0005102;binding#GO:0005488 cellular process#GO:0009987;cell adhesion mediated by integrin#GO:0033627;cell-matrix adhesion#GO:0007160;cell adhesion#GO:0007155;cell-substrate adhesion#GO:0031589 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012 HUMAN|HGNC=7943|UniProtKB=P16066 P16066 NPR1 PTHR11920:SF300 GUANYLYL CYCLASE ATRIAL NATRIURETIC PEPTIDE RECEPTOR 1 signaling receptor activity#GO:0038023;guanylate cyclase activity#GO:0004383;peptide receptor activity#GO:0001653;cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824;molecular transducer activity#GO:0060089;lyase activity#GO:0016829 ribose phosphate biosynthetic process#GO:0046390;signal transduction#GO:0007165;receptor guanylyl cyclase signaling pathway#GO:0007168;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;cyclic purine nucleotide metabolic process#GO:0052652;cell surface receptor signaling pathway#GO:0007166;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;signaling#GO:0023052;phosphorus metabolic process#GO:0006793;regulation of biological process#GO:0050789;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide biosynthetic process#GO:0009165;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;ribonucleotide metabolic process#GO:0009259;cyclic nucleotide biosynthetic process#GO:0009190;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;carbohydrate derivative metabolic process#GO:1901135;cGMP metabolic process#GO:0046068;nucleoside phosphate biosynthetic process#GO:1901293;cyclic nucleotide metabolic process#GO:0009187;regulation of cellular process#GO:0050794;nucleoside phosphate metabolic process#GO:0006753;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;cGMP biosynthetic process#GO:0006182;enzyme-linked receptor protein signaling pathway#GO:0007167;organophosphate biosynthetic process#GO:0090407 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 guanylate cyclase#PC00114;lyase#PC00144 HUMAN|HGNC=30784|UniProtKB=Q14140 Q14140 SERTAD2 PTHR16277:SF10 CELL DIVISION CYCLE ASSOCIATED PROTEIN 4/SERTA DOMAIN-CONTAINING PROTEIN 2 SERTA DOMAIN-CONTAINING PROTEIN 2 transcription coactivator activity#GO:0003713;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 transcription cofactor#PC00217 HUMAN|HGNC=15981|UniProtKB=Q8WUU4 Q8WUU4 ZNF296 PTHR45993:SF2 B-CELL LYMPHOMA/LEUKEMIA 11 ZINC FINGER PROTEIN 296 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of cellular component organization#GO:0051129;regulation of developmental process#GO:0050793;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of dendrite development#GO:0050773;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of neuron projection development#GO:0010975;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cell projection organization#GO:0031344;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of biosynthetic process#GO:0009889 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=8592|UniProtKB=O75914 O75914 PAK3 PTHR48015:SF30 SERINE/THREONINE-PROTEIN KINASE TAO SERINE_THREONINE-PROTEIN KINASE PAK 3 protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096 regulation of MAPK cascade#GO:0043408;regulation of anatomical structure morphogenesis#GO:0022603;regulation of axonogenesis#GO:0050770;response to stress#GO:0006950;regulation of neuron projection development#GO:0010975;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of actin cytoskeleton organization#GO:0032956;regulation of intracellular signal transduction#GO:1902531;cellular response to stress#GO:0033554;regulation of signaling#GO:0023051;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;response to stimulus#GO:0050896;regulation of cellular component organization#GO:0051128;signaling#GO:0023052;cellular response to starvation#GO:0009267;regulation of cell projection organization#GO:0031344;regulation of actin filament-based process#GO:0032970;cellular response to nutrient levels#GO:0031669;regulation of response to stimulus#GO:0048583;regulation of plasma membrane bounded cell projection organization#GO:0120035;response to nutrient levels#GO:0031667;cell migration#GO:0016477;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;response to starvation#GO:0042594;cellular response to stimulus#GO:0051716;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794;cell motility#GO:0048870;regulation of developmental process#GO:0050793;regulation of cell communication#GO:0010646 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 Cytoskeletal regulation by Rho GTPase#P00016>PAK#P00517;T cell activation#P00053>PAK#P01319;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PAK#P00837;Angiogenesis#P00005>PAK#P00249;Ras Pathway#P04393>PAK#P04553 HUMAN|HGNC=29303|UniProtKB=Q9P1Z9 Q9P1Z9 CCDC180 PTHR21444:SF14 COILED-COIL DOMAIN-CONTAINING PROTEIN 180 COILED-COIL DOMAIN-CONTAINING PROTEIN 180 HUMAN|HGNC=34518|UniProtKB=Q96AW1 Q96AW1 VOPP1 PTHR14971:SF2 VESICULAR, OVEREXPRESSED IN CANCER, PROSURVIVAL PROTEIN 1 WW DOMAIN BINDING PROTEIN VOPP1 protein sequestering activity#GO:0140311;molecular sequestering activity#GO:0140313 regulation of intracellular signal transduction#GO:1902531;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of canonical NF-kappaB signal transduction#GO:0043122;regulation of biological process#GO:0050789 vacuolar membrane#GO:0005774;lytic vacuole#GO:0000323;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;late endosome membrane#GO:0031902;late endosome#GO:0005770;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;cytoplasm#GO:0005737;vacuole#GO:0005773;membrane#GO:0016020;vesicle membrane#GO:0012506;lysosomal membrane#GO:0005765;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endosome membrane#GO:0010008;endosome#GO:0005768;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;lytic vacuole membrane#GO:0098852;lysosome#GO:0005764;vesicle#GO:0031982 HUMAN|HGNC=10824|UniProtKB=Q9Y3L3 Q9Y3L3 SH3BP1 PTHR14130:SF12 3BP-1 RELATED RHOGAP BARGIN-RELATED enzyme activator activity#GO:0008047;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695 negative regulation of response to stimulus#GO:0048585;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of actin cytoskeleton organization#GO:0032956;negative regulation of signal transduction#GO:0009968;regulation of small GTPase mediated signal transduction#GO:0051056;negative regulation of cellular process#GO:0048523;regulation of actin filament-based process#GO:0032970;regulation of response to stimulus#GO:0048583;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;cytosol#GO:0005829 GTPase-activating protein#PC00257 HUMAN|HGNC=669|UniProtKB=P08134 P08134 RHOC PTHR24072:SF100 RHO FAMILY GTPASE RHO-RELATED GTP-BINDING PROTEIN RHOC purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;protein binding#GO:0005515;protein kinase binding#GO:0019901;guanyl nucleotide binding#GO:0019001;enzyme binding#GO:0019899;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;kinase binding#GO:0019900;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;GTPase activity#GO:0003924;ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168 cytokinesis#GO:0000910;cytoskeleton-dependent cytokinesis#GO:0061640;cellular component organization#GO:0016043;regulation of organelle organization#GO:0033043;cell cycle process#GO:0022402;regulation of biological process#GO:0050789;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;signaling#GO:0023052;cellular component organization or biogenesis#GO:0071840;organelle organization#GO:0006996;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of actin cytoskeleton organization#GO:0032956;cytoskeleton organization#GO:0007010;actin filament-based process#GO:0030029;cell communication#GO:0007154;supramolecular fiber organization#GO:0097435;cell cycle#GO:0007049;cell division#GO:0051301;cellular response to stimulus#GO:0051716;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;mitotic cytokinesis#GO:0000281;cell motility#GO:0048870;mitotic cell cycle#GO:0000278;regulation of cytoskeleton organization#GO:0051493;regulation of actin filament-based process#GO:0032970;actin filament organization#GO:0007015;mitotic cell cycle process#GO:1903047;cell migration#GO:0016477;biological regulation#GO:0065007 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;cytosol#GO:0005829 G-protein#PC00020;small GTPase#PC00208 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Rho#P00860;Angiotensin II-stimulated signaling through G proteins and beta-arrestin#P05911>RhoA#P05938;Cytoskeletal regulation by Rho GTPase#P00016>Rho#P00507;Angiogenesis#P00005>GTPase#P00254;Integrin signalling pathway#P00034>Rho#P00948;Axon guidance mediated by Slit/Robo#P00008>Rho#P00355;Ras Pathway#P04393>Rho#P04578;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>RhoA#P00740;Axon guidance mediated by semaphorins#P00007>Rho#P00341 HUMAN|HGNC=29035|UniProtKB=O43314 O43314 PPIP5K2 PTHR12750:SF10 DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE INOSITOL HEXAKISPHOSPHATE AND DIPHOSPHOINOSITOL-PENTAKISPHOSPHATE KINASE 2 transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, phosphate group as acceptor#GO:0016776 phosphorus metabolic process#GO:0006793;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;alcohol biosynthetic process#GO:0046165;small molecule metabolic process#GO:0044281;biosynthetic process#GO:0009058;alcohol metabolic process#GO:0006066;metabolic process#GO:0008152;small molecule biosynthetic process#GO:0044283;organophosphate biosynthetic process#GO:0090407 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 nucleotide kinase#PC00172;kinase#PC00137 HUMAN|HGNC=6541|UniProtKB=P07195 P07195 LDHB PTHR43128:SF35 L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+)) L-LACTATE DEHYDROGENASE B CHAIN catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614 energy derivation by oxidation of organic compounds#GO:0015980;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;generation of precursor metabolites and energy#GO:0006091;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;monocarboxylic acid catabolic process#GO:0072329;pyruvate metabolic process#GO:0006090;small molecule catabolic process#GO:0044282;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 oxidoreductase#PC00176;dehydrogenase#PC00092 HUMAN|HGNC=20150|UniProtKB=P59190 P59190 RAB15 PTHR47980:SF4 LD44762P RAS-RELATED PROTEIN RAB-15 export from cell#GO:0140352;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;secretion by cell#GO:0032940;exocytosis#GO:0006887;localization#GO:0051179;establishment of localization#GO:0051234;secretion#GO:0046903;transport#GO:0006810 intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;endosome membrane#GO:0010008;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;membrane#GO:0016020;vesicle membrane#GO:0012506 HUMAN|HGNC=11983|UniProtKB=O75674 O75674 TOM1L1 PTHR13856:SF28 VHS DOMAIN CONTAINING PROTEIN FAMILY TOM1-LIKE PROTEIN 1 protein binding#GO:0005515;clathrin binding#GO:0030276;binding#GO:0005488 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154 intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 HUMAN|HGNC=1706|UniProtKB=P01732 P01732 CD8A PTHR10441:SF2 CD8 ALPHA CHAIN T-CELL SURFACE GLYCOPROTEIN CD8 ALPHA CHAIN lymphocyte differentiation#GO:0030098;T cell mediated immunity#GO:0002456;regulation of immune response#GO:0050776;cell activation#GO:0001775;cell communication#GO:0007154;anatomical structure development#GO:0048856;leukocyte activation#GO:0045321;cellular response to stimulus#GO:0051716;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;immune response-activating cell surface receptor signaling pathway#GO:0002429;T cell receptor signaling pathway#GO:0050852;positive regulation of immune response#GO:0050778;developmental process#GO:0032502;regulation of response to stimulus#GO:0048583;cellular developmental process#GO:0048869;immune response#GO:0006955;positive regulation of response to stimulus#GO:0048584;multicellular organismal process#GO:0032501;hemopoiesis#GO:0030097;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;adaptive immune response#GO:0002250;immune system process#GO:0002376;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;T cell activation#GO:0042110;leukocyte differentiation#GO:0002521;regulation of biological process#GO:0050789;mononuclear cell differentiation#GO:1903131;immune response-regulating signaling pathway#GO:0002764;response to stimulus#GO:0050896;cell differentiation#GO:0030154;signaling#GO:0023052;cell development#GO:0048468;immune effector process#GO:0002252;cell surface receptor signaling pathway#GO:0007166;immune response-activating signaling pathway#GO:0002757;positive regulation of immune system process#GO:0002684;activation of immune response#GO:0002253;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;antigen receptor-mediated signaling pathway#GO:0050851;lymphocyte activation#GO:0046649;T cell differentiation#GO:0030217 membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;plasma membrane#GO:0005886 HUMAN|HGNC=15917|UniProtKB=Q9NQ66 Q9NQ66 PLCB1 PTHR10336:SF12 PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN 1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-1 hydrolase activity, acting on ester bonds#GO:0016788;phospholipase activity#GO:0120569;calmodulin binding#GO:0005516;catalytic activity#GO:0003824;glycerophospholipase activity#GO:0004620;phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578;lipase activity#GO:0016298;binding#GO:0005488;hydrolase activity#GO:0016787;protein binding#GO:0005515 signaling#GO:0023052;glycerolipid metabolic process#GO:0046486;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;calcium ion transmembrane transport#GO:0070588;phosphorus metabolic process#GO:0006793;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;nervous system process#GO:0050877;G protein-coupled receptor signaling pathway#GO:0007186;monoatomic cation transmembrane transport#GO:0098655;glycerophospholipid metabolic process#GO:0006650;signal transduction#GO:0007165;release of sequestered calcium ion into cytosol#GO:0051209;cellular process#GO:0009987;calcium ion transport#GO:0006816;calcium ion transmembrane import into cytosol#GO:0097553;metabolic process#GO:0008152;phospholipid metabolic process#GO:0006644;metal ion transport#GO:0030001;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;intracellular signal transduction#GO:0035556;monoatomic cation transport#GO:0006812;cell communication#GO:0007154;localization#GO:0051179;cognition#GO:0050890;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;multicellular organismal process#GO:0032501;organophosphate metabolic process#GO:0019637;system process#GO:0003008;establishment of localization#GO:0051234;phosphatidylinositol metabolic process#GO:0046488;transport#GO:0006810;lipid metabolic process#GO:0006629 nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;nuclear body#GO:0016604;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;membraneless organelle#GO:0043228;nuclear speck#GO:0016607;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;phospholipase#PC00186;lipase#PC00143;hydrolase#PC00121 Thyrotropin-releasing hormone receptor signaling pathway#P04394>PLC#P04581;CCKR signaling map#P06959>PLC_beta#P07110;Gonadotropin-releasing hormone receptor pathway#P06664>PLCbeta#P06705;Alpha adrenergic receptor signaling pathway#P00002>PLC#P00073;2-arachidonoylglycerol biosynthesis#P05726>PLC#P05738;Oxytocin receptor mediated signaling pathway#P04391>PLC beta#P04530;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PLCbetagamma#P00874;Wnt signaling pathway#P00057>Phospholipase C#P01443;Angiotensin II-stimulated signaling through G proteins and beta-arrestin#P05911>PLC#P05933;Endogenous cannabinoid signaling#P05730>PLC#P05746;5HT2 type receptor mediated signaling pathway#P04374>PLC#P04412;Endothelin signaling pathway#P00019>PLCbeta#P00591;Histamine H1 receptor mediated signaling pathway#P04385>PLC#P04484;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Phospholipase C-beta#P00744 HUMAN|HGNC=16617|UniProtKB=Q9C0J9 Q9C0J9 BHLHE41 PTHR10985:SF76 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED CLASS E BASIC HELIX-LOOP-HELIX PROTEIN 41 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 circadian rhythm#GO:0007623;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;rhythmic process#GO:0048511;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of multicellular organismal development#GO:2000026;negative regulation of biological process#GO:0048519;circadian regulation of gene expression#GO:0032922;multicellular organism development#GO:0007275;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;anterior/posterior pattern specification#GO:0009952;regulation of multicellular organismal process#GO:0051239;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of nervous system development#GO:0051960;pattern specification process#GO:0007389;regulation of developmental process#GO:0050793;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of neurogenesis#GO:0050767;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;regulation of cell differentiation#GO:0045595;negative regulation of cellular process#GO:0048523;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;regionalization#GO:0003002;multicellular organismal process#GO:0032501;negative regulation of macromolecule metabolic process#GO:0010605;regulation of cell development#GO:0060284;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=28320|UniProtKB=Q8TAP8 Q8TAP8 PPP1R35 PTHR28625:SF1 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 35 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 35 regulation of cilium assembly#GO:1902017;regulation of cell projection organization#GO:0031344;regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of organelle assembly#GO:1902115;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of cellular component biogenesis#GO:0044089;positive regulation of cell cycle#GO:0045787;biological regulation#GO:0065007;regulation of cell cycle process#GO:0010564;regulation of microtubule-based process#GO:0032886;positive regulation of cell projection organization#GO:0031346;positive regulation of cellular component organization#GO:0051130;positive regulation of organelle organization#GO:0010638;regulation of cell projection assembly#GO:0060491;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;positive regulation of cell cycle process#GO:0090068;regulation of cellular process#GO:0050794;regulation of plasma membrane bounded cell projection assembly#GO:0120032;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;regulation of cellular component biogenesis#GO:0044087;regulation of cell cycle#GO:0051726 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;centriole#GO:0005814;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630 phosphatase modulator#PC00184 HUMAN|HGNC=4554|UniProtKB=P18283 P18283 GPX2 PTHR11592:SF36 GLUTATHIONE PEROXIDASE GLUTATHIONE PEROXIDASE 2 oxidoreductase activity, acting on peroxide as acceptor#GO:0016684;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;antioxidant activity#GO:0016209;peroxidase activity#GO:0004601 response to stress#GO:0006950;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;response to chemical#GO:0042221;cellular response to oxidative stress#GO:0034599;cellular response to chemical stimulus#GO:0070887;cellular response to stress#GO:0033554;response to oxidative stress#GO:0006979;cellular response to chemical stress#GO:0062197 peroxidase#PC00180;oxidoreductase#PC00176 HUMAN|HGNC=49193|UniProtKB=A0A0G2JMD5 A0A0G2JMD5 PRAMEF33 PTHR14224:SF28 SIMILAR TO PREFERENTIALLY EXPRESSED ANTIGEN IN MELANOMA-LIKE 3 PRAME FAMILY MEMBER 10-RELATED ubiquitin-like ligase-substrate adaptor activity#GO:1990756;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;enzyme-substrate adaptor activity#GO:0140767 proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161 transferase complex#GO:1990234;catalytic complex#GO:1902494;Cul2-RING ubiquitin ligase complex#GO:0031462;ubiquitin ligase complex#GO:0000151;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cullin-RING ubiquitin ligase complex#GO:0031461;cytoplasm#GO:0005737 HUMAN|HGNC=9282|UniProtKB=P62140 P62140 PPP1CB PTHR11668:SF472 SERINE/THREONINE PROTEIN PHOSPHATASE SERINE_THREONINE-PROTEIN PHOSPHATASE PP1-BETA CATALYTIC SUBUNIT protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 rhythmic process#GO:0048511;regulation of biosynthetic process#GO:0009889;circadian rhythm#GO:0007623;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;circadian regulation of gene expression#GO:0032922;regulation of macromolecule biosynthetic process#GO:0010556;regulation of circadian rhythm#GO:0042752;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007 nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195 Dopamine receptor mediated signaling pathway#P05912>Protein Phosphatase-1#P05969;Nicotine pharmacodynamics pathway#P06587>PPP1CA#P06602 HUMAN|HGNC=15803|UniProtKB=Q9NU02 Q9NU02 ANKEF1 PTHR24127:SF1 ANKYRIN REPEAT AND EF-HAND DOMAIN-CONTAINING PROTEIN 1 ANKYRIN REPEAT AND EF-HAND DOMAIN-CONTAINING PROTEIN 1 HUMAN|HGNC=20060|UniProtKB=Q70CQ4 Q70CQ4 USP31 PTHR21646:SF44 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 31 deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787;cysteine-type deubiquitinase activity#GO:0004843;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783 regulation of protein stability#GO:0031647;regulation of biological quality#GO:0065008;biological regulation#GO:0065007 cysteine protease#PC00081 HUMAN|HGNC=44112|UniProtKB=H3BS89 H3BS89 TMEM178B PTHR32005:SF1 TRANSMEMBRANE PROTEIN 178B-RELATED TRANSMEMBRANE PROTEIN 178B cellular anatomical structure#GO:0110165;membrane#GO:0016020 HUMAN|HGNC=15161|UniProtKB=Q8NGN8 Q8NGN8 OR4A4P PTHR48002:SF121 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 4A4-RELATED olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=29094|UniProtKB=O75153 O75153 CLUH PTHR12601:SF54 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3 CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG RNA binding#GO:0003723;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488 organelle localization#GO:0051640;mitochondrion localization#GO:0051646;localization#GO:0051179 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 translation initiation factor#PC00224 HUMAN|HGNC=9842|UniProtKB=Q12967 Q12967 RALGDS PTHR23113:SF35 GUANINE NUCLEOTIDE EXCHANGE FACTOR RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR guanyl-nucleotide exchange factor activity#GO:0005085;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function regulator activity#GO:0098772 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;Ras protein signal transduction#GO:0007265;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;small GTPase-mediated signal transduction#GO:0007264;intracellular signaling cassette#GO:0141124;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 guanyl-nucleotide exchange factor#PC00113 Ras Pathway#P04393>RalGDS#P04551 HUMAN|HGNC=4527|UniProtKB=Q9P296 Q9P296 C5AR2 PTHR24225:SF1 CHEMOTACTIC RECEPTOR C5A ANAPHYLATOXIN CHEMOTACTIC RECEPTOR 2 immune receptor activity#GO:0140375;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 immune response-activating signaling pathway#GO:0002757;positive regulation of immune response#GO:0050778;cell surface receptor signaling pathway#GO:0007166;regulation of response to stimulus#GO:0048583;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;positive regulation of response to stimulus#GO:0048584;activation of immune response#GO:0002253;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of immune system process#GO:0002684;regulation of biological quality#GO:0065008;cell communication#GO:0007154;regulation of immune response#GO:0050776;phospholipase C-activating G protein-coupled receptor signaling pathway#GO:0007200;immune system process#GO:0002376;positive regulation of cytosolic calcium ion concentration#GO:0007204;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052;immune response-activating cell surface receptor signaling pathway#GO:0002429;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;immune response-regulating signaling pathway#GO:0002764 membrane#GO:0016020;basolateral plasma membrane#GO:0016323;basal part of cell#GO:0045178;cell periphery#GO:0071944;basal plasma membrane#GO:0009925;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=30926|UniProtKB=Q8N5C7 Q8N5C7 DTWD1 PTHR15627:SF15 NATURAL KILLER CELL-SPECIFIC ANTIGEN KLIP1 TRNA-URIDINE AMINOCARBOXYPROPYLTRANSFERASE 1 catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765 RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;tRNA modification#GO:0006400;RNA biosynthetic process#GO:0032774;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=26272|UniProtKB=Q6NSJ5 Q6NSJ5 LRRC8E PTHR45752:SF8 LEUCINE-RICH REPEAT-CONTAINING VOLUME-REGULATED ANION CHANNEL SUBUNIT LRRC8E monoatomic anion channel activity#GO:0005253;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic anion transmembrane transporter activity#GO:0008509;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 import into cell#GO:0098657;amino acid transport#GO:0006865;organic acid transport#GO:0015849;acidic amino acid transport#GO:0015800;carboxylic acid transport#GO:0046942;monoatomic anion transmembrane transport#GO:0098656;cellular process#GO:0009987;signal transduction#GO:0007165;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;response to stimulus#GO:0050896;import across plasma membrane#GO:0098739;signaling#GO:0023052;regulation of biological process#GO:0050789;establishment of localization#GO:0051234;transport#GO:0006810;C4-dicarboxylate transport#GO:0015740;monoatomic ion transmembrane transport#GO:0034220;dicarboxylic acid transport#GO:0006835;biological regulation#GO:0065007;nitrogen compound transport#GO:0071705;aspartate transmembrane transport#GO:0015810;amino acid transmembrane transport#GO:0003333;localization#GO:0051179;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of cellular process#GO:0050794;nucleobase-containing compound transport#GO:0015931;organophosphate ester transport#GO:0015748;carboxylic acid transmembrane transport#GO:1905039;monoatomic anion transport#GO:0006820;carbohydrate derivative transport#GO:1901264;cellular response to stimulus#GO:0051716 transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;cytoplasm#GO:0005737;plasma membrane#GO:0005886;membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HUMAN|HGNC=24198|UniProtKB=P78358 P78358 CTAG1A PTHR31283:SF4 EKC/KEOPS COMPLEX SUBUNIT PCC1 FAMILY MEMBER CANCER_TESTIS ANTIGEN 1 catalytic complex#GO:1902494;transferase complex#GO:1990234;protein-containing complex#GO:0032991 HUMAN|HGNC=6717|UniProtKB=Q8N2S1 Q8N2S1 LTBP4 PTHR24034:SF43 EGF-LIKE DOMAIN-CONTAINING PROTEIN LATENT-TRANSFORMING GROWTH FACTOR BETA-BINDING PROTEIN 4 transforming growth factor beta binding#GO:0050431;binding#GO:0005488;growth factor binding#GO:0019838;protein binding#GO:0005515;cytokine binding#GO:0019955 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 extracellular matrix structural protein#PC00103;extracellular matrix protein#PC00102 HUMAN|HGNC=11056|UniProtKB=P48067 P48067 SLC6A9 PTHR11616:SF263 SODIUM/CHLORIDE DEPENDENT TRANSPORTER SODIUM- AND CHLORIDE-DEPENDENT GLYCINE TRANSPORTER 1 symporter activity#GO:0015293;monoatomic cation transmembrane transporter activity#GO:0008324;amino acid:sodium symporter activity#GO:0005283;solute:sodium symporter activity#GO:0015370;secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;amino acid transmembrane transporter activity#GO:0015171;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;solute:monoatomic cation symporter activity#GO:0015294;monoatomic ion transmembrane transporter activity#GO:0015075 import into cell#GO:0098657;establishment of localization#GO:0051234;transport#GO:0006810;carboxylic acid transport#GO:0046942;organic acid transport#GO:0015849;amino acid transport#GO:0006865;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;nitrogen compound transport#GO:0071705;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;amino acid transmembrane transport#GO:0003333;neutral amino acid transport#GO:0015804;glycine transport#GO:0015816;metal ion transport#GO:0030001;carboxylic acid transmembrane transport#GO:1905039;import across plasma membrane#GO:0098739;sodium ion transport#GO:0006814 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 primary active transporter#PC00068 HUMAN|HGNC=17619|UniProtKB=Q9NXR1 Q9NXR1 NDE1 PTHR10921:SF2 NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG 1 NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG 1 protein binding#GO:0005515;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;microtubule binding#GO:0008017 microtubule cytoskeleton organization#GO:0000226;organelle fission#GO:0048285;localization#GO:0051179;supramolecular fiber organization#GO:0097435;organelle localization#GO:0051640;cell motility#GO:0048870;microtubule-based movement#GO:0007018;mitotic cell cycle#GO:0000278;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cell cycle#GO:0007049;establishment of cell polarity#GO:0030010;establishment of mitotic spindle orientation#GO:0000132;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;microtubule polymerization#GO:0046785;mitotic cell cycle process#GO:1903047;vesicle cytoskeletal trafficking#GO:0099518;intracellular transport#GO:0046907;vesicle transport along microtubule#GO:0047496;transport#GO:0006810;cell migration#GO:0016477;cytoskeleton-dependent intracellular transport#GO:0030705;microtubule polymerization or depolymerization#GO:0031109;vesicle localization#GO:0051648;establishment of spindle localization#GO:0051293;cellular localization#GO:0051641;spindle localization#GO:0051653;nuclear division#GO:0000280;establishment or maintenance of cell polarity#GO:0007163;microtubule-based transport#GO:0099111;establishment of organelle localization#GO:0051656;centrosome localization#GO:0051642;cellular component organization#GO:0016043;microtubule nucleation#GO:0007020;mitotic nuclear division#GO:0140014;cell cycle process#GO:0022402;protein-containing complex assembly#GO:0065003;protein polymerization#GO:0051258;centrosome cycle#GO:0007098;cellular component organization or biogenesis#GO:0071840;establishment of spindle orientation#GO:0051294;microtubule-based process#GO:0007017;protein-containing complex organization#GO:0043933;microtubule organizing center organization#GO:0031023;chromosome segregation#GO:0007059;cellular component assembly#GO:0022607;chromosome localization#GO:0050000;organelle transport along microtubule#GO:0072384;cytoskeleton organization#GO:0007010;establishment of vesicle localization#GO:0051650;establishment of mitotic spindle localization#GO:0040001;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of localization in cell#GO:0051649 kinetochore#GO:0000776;chromosome#GO:0005694;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687;microtubule cytoskeleton#GO:0015630;condensed chromosome, centromeric region#GO:0000779;intracellular membraneless organelle#GO:0043232;supramolecular complex#GO:0099080;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;microtubule organizing center#GO:0005815;centrosome#GO:0005813;condensed chromosome#GO:0000793;chromosome, centromeric region#GO:0000775;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228 HUMAN|HGNC=28923|UniProtKB=Q8NCG7 Q8NCG7 DAGLB PTHR45792:SF2 DIACYLGLYCEROL LIPASE HOMOLOG-RELATED DIACYLGLYCEROL LIPASE-BETA hydrolase activity#GO:0016787;triacylglycerol lipase activity#GO:0004806;lipase activity#GO:0016298;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;carboxylic ester hydrolase activity#GO:0052689 primary metabolic process#GO:0044238;catabolic process#GO:0009056;system development#GO:0048731;anatomical structure development#GO:0048856;multicellular organismal process#GO:0032501;developmental process#GO:0032502;neutral lipid catabolic process#GO:0046461;lipid metabolic process#GO:0006629;fatty acid metabolic process#GO:0006631;acylglycerol metabolic process#GO:0006639;neurogenesis#GO:0022008;neutral lipid metabolic process#GO:0006638;cellular developmental process#GO:0048869;arachidonate metabolic process#GO:0019369;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;cell differentiation#GO:0030154;small molecule metabolic process#GO:0044281;glycerolipid metabolic process#GO:0046486;oxoacid metabolic process#GO:0043436;olefinic compound metabolic process#GO:0120254;glycerolipid catabolic process#GO:0046503;animal gross anatomical part developmental process#GO:0160108;lipid catabolic process#GO:0016042;cellular process#GO:0009987;long-chain fatty acid metabolic process#GO:0001676;nervous system development#GO:0007399;icosanoid metabolic process#GO:0006690;unsaturated fatty acid metabolic process#GO:0033559;metabolic process#GO:0008152;acylglycerol catabolic process#GO:0046464;multicellular organism development#GO:0007275 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 metabolite interconversion enzyme#PC00262;lipase#PC00143;hydrolase#PC00121 HUMAN|HGNC=13824|UniProtKB=Q96T76 Q96T76 MMS19 PTHR12891:SF1 DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19 MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152 microtubule cytoskeleton#GO:0015630;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;spindle#GO:0005819;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228 scaffold/adaptor protein#PC00226 HUMAN|HGNC=29266|UniProtKB=Q9P2G3 Q9P2G3 KLHL14 PTHR45632:SF6 LD33804P KELCH-LIKE PROTEIN 14 ubiquitin-like ligase-substrate adaptor activity#GO:1990756;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;enzyme-substrate adaptor activity#GO:0140767 ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238 neuron projection#GO:0043005;cytoplasm#GO:0005737;somatodendritic compartment#GO:0036477;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;endoplasmic reticulum#GO:0005783;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;Cul3-RING ubiquitin ligase complex#GO:0031463;cell body#GO:0044297;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cullin-RING ubiquitin ligase complex#GO:0031461;neuronal cell body#GO:0043025;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ubiquitin ligase complex#GO:0000151 scaffold/adaptor protein#PC00226 HUMAN|HGNC=9989|UniProtKB=Q15493 Q15493 RGN PTHR10907:SF54 REGUCALCIN REGUCALCIN hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 regulation of cell communication#GO:0010646;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of calcium-mediated signaling#GO:0050848;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634 metabolite interconversion enzyme#PC00262;esterase#PC00097 HUMAN|HGNC=29600|UniProtKB=A0JLT2 A0JLT2 MED19 PTHR22536:SF1 LUNG CANCER METASTASIS-RELATED LCMR1 PROTEIN MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 19 regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of biological process#GO:0050789;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219 organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;mediator complex#GO:0016592;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=7001|UniProtKB=O14770 O14770 MEIS2 PTHR11850:SF47 HOMEOBOX PROTEIN TRANSCRIPTION FACTORS HOMEOBOX PROTEIN MEIS2 sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;sequence-specific DNA binding#GO:0043565;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription activator activity#GO:0001216;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488 pattern specification process#GO:0007389;regulation of cell population proliferation#GO:0042127;positive regulation of biosynthetic process#GO:0009891;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;animal organ morphogenesis#GO:0009887;visual system development#GO:0150063;positive regulation of RNA metabolic process#GO:0051254;sensory organ development#GO:0007423;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;brain development#GO:0007420;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;animal gross anatomical part developmental process#GO:0160108;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;eye development#GO:0001654;positive regulation of cell population proliferation#GO:0008284;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;central nervous system development#GO:0007417;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;multicellular organism development#GO:0007275;animal organ development#GO:0048513;embryonic pattern specification#GO:0009880;sensory system development#GO:0048880;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604;embryo development#GO:0009790;head development#GO:0060322;nervous system development#GO:0007399 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=16454|UniProtKB=Q9GZQ4 Q9GZQ4 NMUR2 PTHR24243:SF14 G-PROTEIN COUPLED RECEPTOR NEUROMEDIN-U RECEPTOR 2 G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;neuropeptide receptor activity#GO:0008188;transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;phospholipase C-activating G protein-coupled receptor signaling pathway#GO:0007200;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;neuropeptide signaling pathway#GO:0007218;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021 HUMAN|HGNC=8512|UniProtKB=P00480 P00480 OTC PTHR45753:SF8 ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL ORNITHINE TRANSCARBAMYLASE, MITOCHONDRIAL transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring one-carbon groups#GO:0016741 small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;amino acid biosynthetic process#GO:0008652;L-arginine biosynthetic process#GO:0006526;proteinogenic amino acid biosynthetic process#GO:0170038;carboxylic acid biosynthetic process#GO:0046394;cellular process#GO:0009987;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;arginine metabolic process#GO:0006525;small molecule metabolic process#GO:0044281;proteinogenic amino acid metabolic process#GO:0170039 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 transferase#PC00220 Arginine biosynthesis#P02728>Ornithine carbamoyl transferase#P02846 HUMAN|HGNC=11311|UniProtKB=Q05066 Q05066 SRY PTHR10270:SF336 SOX TRANSCRIPTION FACTOR SEX-DETERMINING REGION Y PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription cis-regulatory region binding#GO:0000976;sequence-specific DNA binding#GO:0043565;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulator activity#GO:0140110;DNA-binding transcription activator activity#GO:0001216 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;multicellular organismal process#GO:0032501;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;developmental process involved in reproduction#GO:0003006;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;reproductive process#GO:0022414;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of transcription by RNA polymerase II#GO:0045944;multicellular organism development#GO:0007275;regulation of biological process#GO:0050789;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 DNA-binding transcription factor#PC00218;HMG box transcription factor#PC00024;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=8878|UniProtKB=Q01813 Q01813 PFKP PTHR13697:SF5 PHOSPHOFRUCTOKINASE ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE, PLATELET TYPE anion binding#GO:0043168;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;transferase activity#GO:0016740;carbohydrate kinase activity#GO:0019200;carbohydrate derivative binding#GO:0097367;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;nicotinamide nucleotide metabolic process#GO:0046496;ADP catabolic process#GO:0046032;monosaccharide metabolic process#GO:0005996;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;purine nucleoside diphosphate catabolic process#GO:0009137;nucleobase-containing small molecule metabolic process#GO:0055086;glucose metabolic process#GO:0006006;purine-containing compound catabolic process#GO:0072523;pyridine-containing compound catabolic process#GO:0072526;purine-containing compound metabolic process#GO:0072521;ribonucleoside diphosphate metabolic process#GO:0009185;purine nucleotide metabolic process#GO:0006163;phosphorus metabolic process#GO:0006793;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;small molecule catabolic process#GO:0044282;pyridine nucleotide catabolic process#GO:0019364;pyruvate metabolic process#GO:0006090;small molecule metabolic process#GO:0044281;purine nucleoside diphosphate metabolic process#GO:0009135;ribonucleotide metabolic process#GO:0009259;oxoacid metabolic process#GO:0043436;carbohydrate catabolic process#GO:0016052;nucleotide metabolic process#GO:0009117;purine ribonucleoside triphosphate metabolic process#GO:0009205;glycolytic process#GO:0006096;ribonucleotide catabolic process#GO:0009261;carbohydrate derivative metabolic process#GO:1901135;organophosphate metabolic process#GO:0019637;nucleobase-containing compound catabolic process#GO:0034655;nucleobase-containing compound metabolic process#GO:0006139;purine ribonucleoside diphosphate metabolic process#GO:0009179;generation of precursor metabolites and energy#GO:0006091;nucleotide catabolic process#GO:0009166;energy derivation by oxidation of organic compounds#GO:0015980;ADP metabolic process#GO:0046031;nucleoside diphosphate catabolic process#GO:0009134;purine nucleoside triphosphate metabolic process#GO:0009144;purine ribonucleotide catabolic process#GO:0009154;hexose metabolic process#GO:0019318;primary metabolic process#GO:0044238;nucleoside phosphate metabolic process#GO:0006753;carbohydrate derivative catabolic process#GO:1901136;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate metabolic process#GO:0005975;nucleoside phosphate catabolic process#GO:1901292;catabolic process#GO:0009056;purine nucleotide catabolic process#GO:0006195;pyridine-containing compound metabolic process#GO:0072524;nucleoside diphosphate metabolic process#GO:0009132;aerobic respiration#GO:0009060;purine ribonucleoside diphosphate catabolic process#GO:0009181;cellular respiration#GO:0045333;ribonucleoside diphosphate catabolic process#GO:0009191;organophosphate catabolic process#GO:0046434 cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;membrane#GO:0016020;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;transferase complex#GO:1990234;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695 transferase#PC00220;carbohydrate kinase#PC00065;kinase#PC00137 HUMAN|HGNC=2210|UniProtKB=P05997 P05997 COL5A2 PTHR24023:SF1135 COLLAGEN ALPHA COLLAGEN ALPHA-2(V) CHAIN structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 anatomical structure development#GO:0048856;animal organ development#GO:0048513;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;external encapsulating structure organization#GO:0045229;animal gross anatomical part developmental process#GO:0160108;extracellular structure organization#GO:0043062;developmental process#GO:0032502;skin development#GO:0043588;cellular component organization#GO:0016043;cellular process#GO:0009987 extracellular protein-containing complex#GO:0140392;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;interstitial matrix#GO:0005614;supramolecular complex#GO:0099080;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 extracellular matrix structural protein#PC00103;extracellular matrix protein#PC00102 Integrin signalling pathway#P00034>Collagen#P00922 HUMAN|HGNC=18816|UniProtKB=Q6UWL6 Q6UWL6 KIRREL2 PTHR11640:SF51 NEPHRIN KIN OF IRRE-LIKE PROTEIN 2 cell adhesion molecule binding#GO:0050839;binding#GO:0005488;protein binding#GO:0005515 cellular process#GO:0009987;cell adhesion#GO:0007155;cell-cell adhesion#GO:0098609 plasma membrane#GO:0005886;anchoring junction#GO:0070161;cell junction#GO:0030054;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;cell-cell junction#GO:0005911;membrane#GO:0016020 cell adhesion molecule#PC00069;immunoglobulin superfamily cell adhesion molecule#PC00125 HUMAN|HGNC=7126|UniProtKB=Q15773 Q15773 MLF2 PTHR13105:SF4 MYELOID LEUKEMIA FACTOR MYELOID LEUKEMIA FACTOR 2 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 intercellular signal molecule#PC00207 HUMAN|HGNC=3688|UniProtKB=P11362 P11362 FGFR1 PTHR24416:SF131 TYROSINE-PROTEIN KINASE RECEPTOR FIBROBLAST GROWTH FACTOR RECEPTOR 1 protein binding#GO:0005515;phosphotransferase activity, alcohol group as acceptor#GO:0016773;growth factor binding#GO:0019838;protein kinase activity#GO:0004672;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888;fibroblast growth factor binding#GO:0017134;signaling receptor activity#GO:0038023;transferase activity#GO:0016740;kinase activity#GO:0016301;transmembrane receptor protein tyrosine kinase activity#GO:0004714;molecular transducer activity#GO:0060089;catalytic activity, acting on a protein#GO:0140096;transmembrane receptor protein kinase activity#GO:0019199;protein tyrosine kinase activity#GO:0004713;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772 enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of cell population proliferation#GO:0042127;cell communication#GO:0007154;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;response to growth factor#GO:0070848;regulation of cell communication#GO:0010646;regulation of developmental process#GO:0050793;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;positive regulation of MAPK cascade#GO:0043410;response to fibroblast growth factor#GO:0071774;regulation of response to stimulus#GO:0048583;regulation of cell differentiation#GO:0045595;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of developmental process#GO:0051094;fibroblast growth factor receptor signaling pathway#GO:0008543;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of cellular process#GO:0048522;positive regulation of signaling#GO:0023056;cellular response to growth factor stimulus#GO:0071363;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;signaling#GO:0023052;positive regulation of cell population proliferation#GO:0008284;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;cell surface receptor signaling pathway#GO:0007166;positive regulation of cell differentiation#GO:0045597;regulation of MAPK cascade#GO:0043408;cellular process#GO:0009987;cellular response to fibroblast growth factor stimulus#GO:0044344;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518 signaling receptor complex#GO:0043235;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 transmembrane signal receptor#PC00197 FGF signaling pathway#P00021>FGFR1-4#P00636;Angiogenesis#P00005>FGFR-1#P00186 HUMAN|HGNC=10340|UniProtKB=P49207 P49207 RPL34 PTHR46595:SF6 60S RIBOSOMAL PROTEIN L34 LARGE RIBOSOMAL SUBUNIT PROTEIN EL34 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 ribosome#GO:0005840;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 ribosomal protein#PC00202;translational protein#PC00263 HUMAN|HGNC=19431|UniProtKB=O95406 O95406 CNIH1 PTHR12290:SF10 CORNICHON-RELATED PROTEIN CORNICHON HOMOLOG 1 vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;transport#GO:0006810 endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;membrane#GO:0016020;cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;coated vesicle#GO:0030135;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;COPII-coated ER to Golgi transport vesicle#GO:0030134;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175 membrane traffic protein#PC00150 HUMAN|HGNC=25604|UniProtKB=Q8WVR3 Q8WVR3 TRAPPC14 PTHR16096:SF8 MICROTUBULE-ASSOCIATED PROTEIN 11 TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 14 protein binding#GO:0005515;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631 organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031;cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cell projection assembly#GO:0030031;cellular process#GO:0009987;cell projection organization#GO:0030030;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036 vesicle tethering complex#GO:0099023;intracellular protein-containing complex#GO:0140535;Golgi apparatus#GO:0005794;TRAPP complex#GO:0030008;cytoplasm#GO:0005737;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;TRAPPII protein complex#GO:1990071;intracellular vesicle#GO:0097708 membrane traffic protein#PC00150 HUMAN|HGNC=44445|UniProtKB=D6RBQ6 D6RBQ6 USP17L17 PTHR24006:SF651 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE INACTIVE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 17-LIKE PROTEIN 4-RELATED hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;cysteine-type peptidase activity#GO:0008234;cysteine-type deubiquitinase activity#GO:0004843;catalytic activity#GO:0003824 biological regulation#GO:0065007;regulation of biological quality#GO:0065008;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of protein stability#GO:0031647;regulation of apoptotic process#GO:0042981;regulation of programmed cell death#GO:0043067 nucleus#GO:0005634;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 cysteine protease#PC00081;protease#PC00190 HUMAN|HGNC=7746|UniProtKB=P51956 P51956 NEK3 PTHR44984:SF1 SERINE/THREONINE-PROTEIN KINASE NEK3 SERINE_THREONINE-PROTEIN KINASE NEK3 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=6641|UniProtKB=P25800 P25800 LMO1 PTHR45787:SF2 LD11652P RHOMBOTIN-1 transcription coactivator activity#GO:0003713;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=8995|UniProtKB=O14986 O14986 PIP5K1B PTHR23086:SF34 PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE PHOSPHATIDYLINOSITOL 4-PHOSPHATE 5-KINASE TYPE-1 BETA transferase activity#GO:0016740;catalytic activity#GO:0003824;phosphatidylinositol kinase activity#GO:0052742;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773;lipid kinase activity#GO:0001727 lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474;metabolic process#GO:0008152;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;glycerophospholipid metabolic process#GO:0006650;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;organophosphate metabolic process#GO:0019637;organophosphate biosynthetic process#GO:0090407;phosphatidylinositol phosphate biosynthetic process#GO:0046854;phospholipid metabolic process#GO:0006644;phospholipid biosynthetic process#GO:0008654;glycerolipid metabolic process#GO:0046486;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transferase#PC00220;kinase#PC00137 HUMAN|HGNC=20785|UniProtKB=Q5JR12 Q5JR12 PPM1J PTHR13832:SF305 PROTEIN PHOSPHATASE 2C PROTEIN PHOSPHATASE 1J phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoprotein phosphatase activity#GO:0004721;protein serine/threonine phosphatase activity#GO:0004722;hydrolase activity#GO:0016787 cell communication#GO:0007154;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 protein phosphatase#PC00195 HUMAN|HGNC=6916|UniProtKB=Q9UIS9 Q9UIS9 MBD1 PTHR12396:SF57 METHYL-CPG BINDING PROTEIN, MBD METHYL-CPG-BINDING DOMAIN PROTEIN 1 regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;cellular component assembly#GO:0022607;heterochromatin organization#GO:0070828;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;DNA methylation-dependent constitutive heterochromatin formation#GO:0006346;cellular component organization or biogenesis#GO:0071840;negative regulation of gene expression, epigenetic#GO:0045814;constitutive heterochromatin formation#GO:0140719;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;heterochromatin formation#GO:0031507;regulation of DNA-templated transcription#GO:0006355;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;chromatin organization#GO:0006325;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;epigenetic regulation of gene expression#GO:0040029;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=7394|UniProtKB=P07438 P07438 MT1B PTHR23299:SF51 METALLOTHIONEIN METALLOTHIONEIN-1B ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;metal ion binding#GO:0046872;cation binding#GO:0043169 intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;response to metal ion#GO:0010038;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;response to cadmium ion#GO:0046686;detoxification#GO:0098754;response to chemical#GO:0042221;cellular process#GO:0009987;response to stress#GO:0006950;monoatomic ion homeostasis#GO:0050801;detoxification of inorganic compound#GO:0061687;inorganic ion homeostasis#GO:0098771;cellular response to chemical stimulus#GO:0070887;homeostatic process#GO:0042592;response to stimulus#GO:0050896;response to toxic substance#GO:0009636;cellular response to stimulus#GO:0051716;intracellular monoatomic ion homeostasis#GO:0006873 nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 defense/immunity protein#PC00090 HUMAN|HGNC=848|UniProtKB=P56134 P56134 ATP5MF PTHR13080:SF16 ATP SYNTHASE F CHAIN, MITOCHONDRIAL-RELATED ATP SYNTHASE F(0) COMPLEX SUBUNIT F, MITOCHONDRIAL proton transmembrane transporter activity#GO:0015078;catalytic activity#GO:0003824;passive transmembrane transporter activity#GO:0022803;ligase activity#GO:0016874;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;proton channel activity#GO:0015252;proton-transporting ATP synthase activity, rotational mechanism#GO:0046933;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324 cellular respiration#GO:0045333;organophosphate biosynthetic process#GO:0090407;oxidative phosphorylation#GO:0006119;aerobic respiration#GO:0009060;primary metabolic process#GO:0044238;purine nucleoside triphosphate metabolic process#GO:0009144;purine nucleoside triphosphate biosynthetic process#GO:0009145;nucleoside triphosphate metabolic process#GO:0009141;nucleoside phosphate metabolic process#GO:0006753;proton motive force-driven ATP synthesis#GO:0015986;generation of precursor metabolites and energy#GO:0006091;energy derivation by oxidation of organic compounds#GO:0015980;nucleoside phosphate biosynthetic process#GO:1901293;nucleoside triphosphate biosynthetic process#GO:0009142;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;purine ribonucleoside triphosphate metabolic process#GO:0009205;carbohydrate derivative metabolic process#GO:1901135;purine ribonucleoside triphosphate biosynthetic process#GO:0009206;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;ribonucleotide metabolic process#GO:0009259;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;nucleotide biosynthetic process#GO:0009165;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521;proton motive force-driven mitochondrial ATP synthesis#GO:0042776;purine nucleotide metabolic process#GO:0006163;small molecule metabolic process#GO:0044281;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;ATP biosynthetic process#GO:0006754;ribonucleoside triphosphate biosynthetic process#GO:0009201;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;ribose phosphate biosynthetic process#GO:0046390;ribose phosphate metabolic process#GO:0019693;ATP metabolic process#GO:0046034;cellular process#GO:0009987 proton-transporting two-sector ATPase complex#GO:0016469;cation channel complex#GO:0034703;catalytic complex#GO:1902494;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;membrane#GO:0016020;membrane protein complex#GO:0098796;respiratory chain complex#GO:0098803;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;proton-transporting ATP synthase complex#GO:0045259 ATP synthase#PC00002 HUMAN|HGNC=27713|UniProtKB=Q6ZMS4 Q6ZMS4 ZNF852 PTHR24377:SF827 IP01015P-RELATED ZINC FINGER PROTEIN 852 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=28613|UniProtKB=Q5TIA1 Q5TIA1 MEI1 PTHR12044:SF10 BCL2 INTERACTING MEDIATOR OF CELL DEATH MEIOSIS INHIBITOR PROTEIN 1 cellular component organization or biogenesis#GO:0071840;meiotic nuclear division#GO:0140013;organelle fission#GO:0048285;meiotic cell cycle#GO:0051321;meiosis I cell cycle process#GO:0061982;nuclear division#GO:0000280;sexual reproduction#GO:0019953;reproductive process#GO:0022414;organelle organization#GO:0006996;cell cycle#GO:0007049;meiosis I#GO:0007127;cellular component organization#GO:0016043;meiotic cell cycle process#GO:1903046;cell cycle process#GO:0022402;cellular process#GO:0009987 HUMAN|HGNC=18658|UniProtKB=Q92621 Q92621 NUP205 PTHR31344:SF0 NUCLEAR PORE COMPLEX PROTEIN NUP205 NUCLEAR PORE COMPLEX PROTEIN NUP205 structural constituent of nuclear pore#GO:0017056;structural molecule activity#GO:0005198 protein-containing complex organization#GO:0043933;nuclear pore organization#GO:0006999;nucleus organization#GO:0006997;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996 intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear pore#GO:0005643;organelle envelope#GO:0031967;nucleus#GO:0005634;organelle#GO:0043226;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=11328|UniProtKB=O60232 O60232 ZNRD2 PTHR16537:SF1 SJOEGREN SYNDROME/SCLERODERMA AUTOANTIGEN 1 PROTEIN ZNRD2 HUMAN|HGNC=13410|UniProtKB=Q96QS1 Q96QS1 TSPAN32 PTHR19282:SF51 TETRASPANIN TETRASPANIN-32 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=30027|UniProtKB=Q6IE81 Q6IE81 JADE1 PTHR13793:SF79 PHD FINGER PROTEINS PROTEIN JADE-1 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;histone reader activity#GO:0140566;chromatin-protein adaptor activity#GO:0140463 regulation of biological process#GO:0050789;cellular component organization#GO:0016043;chromatin remodeling#GO:0006338;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;chromatin organization#GO:0006325;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of gene expression#GO:0010468;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889 chromatin#GO:0000785;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;transferase complex#GO:1990234;membraneless organelle#GO:0043228;histone acetyltransferase complex#GO:0000123;intracellular protein-containing complex#GO:0140535;chromosome#GO:0005694;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;protein acetyltransferase complex#GO:0031248;acetyltransferase complex#GO:1902493;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=11528|UniProtKB=P29371 P29371 TACR3 PTHR46925:SF1 G-PROTEIN COUPLED RECEPTOR TKR-1-RELATED NEUROMEDIN-K RECEPTOR transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;neuropeptide receptor activity#GO:0008188;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930 biological regulation#GO:0065007;regulation of locomotion#GO:0040012;regulation of microtubule-based movement#GO:0060632;regulation of reproductive process#GO:2000241;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of cell motility#GO:2000147;positive regulation of locomotion#GO:0040017;regulation of cell motility#GO:2000145;regulation of microtubule-based process#GO:0032886 membrane-bounded organelle#GO:0043227;cilium#GO:0005929;9+2 motile cilium#GO:0097729;cell projection#GO:0042995;plasma membrane#GO:0005886;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;motile cilium#GO:0031514;sperm flagellum#GO:0036126;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021 HUMAN|HGNC=4393|UniProtKB=P11488 P11488 GNAT1 PTHR10218:SF67 GTP-BINDING PROTEIN ALPHA SUBUNIT GUANINE NUCLEOTIDE-BINDING PROTEIN G(T) SUBUNIT ALPHA-1 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;molecular function regulator activity#GO:0098772 response to radiation#GO:0009314;cellular process#GO:0009987;signal transduction#GO:0007165;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;system process#GO:0003008;response to external stimulus#GO:0009605;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;response to abiotic stimulus#GO:0009628;sensory perception of light stimulus#GO:0050953;signaling#GO:0023052;regulation of cellular process#GO:0050794;visual perception#GO:0007601;response to stimulus#GO:0050896;response to light stimulus#GO:0009416;nervous system process#GO:0050877;sensory perception#GO:0007600;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 cell periphery#GO:0071944;photoreceptor cell cilium#GO:0097733;neuron projection#GO:0043005;membrane#GO:0016020;9+0 non-motile cilium#GO:0097731;cytoplasm#GO:0005737;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cytoplasmic side of membrane#GO:0098562;extrinsic component of plasma membrane#GO:0019897;extrinsic component of membrane#GO:0019898;plasma membrane protein complex#GO:0098797;cytoplasmic side of plasma membrane#GO:0009898;membrane protein complex#GO:0098796;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;photoreceptor outer segment#GO:0001750;extrinsic component of cytoplasmic side of plasma membrane#GO:0031234;cilium#GO:0005929;catalytic complex#GO:1902494;non-motile cilium#GO:0097730;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;side of membrane#GO:0098552 heterotrimeric G-protein#PC00117;G-protein#PC00020 Opioid proopiomelanocortin pathway#P05917>G-protein#P06012;Metabotropic glutamate receptor group III pathway#P00039>G-Protein#P01045;5HT1 type receptor mediated signaling pathway#P04373>G-protein#P04408;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>G-Protein#P01085;Opioid proenkephalin pathway#P05915>G-protein#P05994;Metabotropic glutamate receptor group II pathway#P00040>G-protein#P01047;Opioid prodynorphin pathway#P05916>G-protein#P06002;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Gialpha#P00712;Dopamine receptor mediated signaling pathway#P05912>Gialpha#P05958;PI3 kinase pathway#P00048>Galpha#P01199;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Galphai#P00828;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Gtalpha#P00760;Enkephalin release#P05913>G-Protein (i)#P05974 HUMAN|HGNC=12651|UniProtKB=P26640 P26640 VARS1 PTHR11946:SF118 VALYL-TRNA SYNTHETASES VALINE--TRNA LIGASE catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;ligase activity#GO:0016874;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a tRNA#GO:0140101 macromolecule metabolic process#GO:0043170;amino acid activation#GO:0043038;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;amino acid metabolic process#GO:0006520;tRNA aminoacylation#GO:0043039;tRNA aminoacylation for protein translation#GO:0006418;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein metabolic process#GO:0019538;RNA metabolic process#GO:0016070;translation#GO:0006412;protein biosynthetic process#GO:0160307;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 aminoacyl-tRNA synthetase#PC00047 HUMAN|HGNC=18395|UniProtKB=O95968 O95968 SCGB1D1 PTHR11332:SF5 SECRETOGLOBIN FAMILY 1D SECRETOGLOBIN FAMILY 1D MEMBER 1 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 transfer/carrier protein#PC00219 HUMAN|HGNC=20284|UniProtKB=O43166 O43166 SIPA1L1 PTHR15711:SF10 RAP GTPASE-ACTIVATING PROTEIN SIGNAL-INDUCED PROLIFERATION-ASSOCIATED 1-LIKE PROTEIN 1 GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047 regulation of cell communication#GO:0010646;regulation of developmental process#GO:0050793;modulation of chemical synaptic transmission#GO:0050804;regulation of cellular process#GO:0050794;actin cytoskeleton organization#GO:0030036;regulation of cellular component organization#GO:0051128;regulation of postsynapse organization#GO:0099175;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;regulation of biological quality#GO:0065008;regulation of synapse structure or activity#GO:0050803;regulation of signaling#GO:0023051;actin filament-based process#GO:0030029;regulation of synapse organization#GO:0050807;regulation of dendritic spine morphogenesis#GO:0061001;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;regulation of trans-synaptic signaling#GO:0099177;cellular process#GO:0009987;regulation of neuron projection development#GO:0010975;organelle organization#GO:0006996;regulation of anatomical structure morphogenesis#GO:0022603;regulation of plasma membrane bounded cell projection organization#GO:0120035;cellular component organization or biogenesis#GO:0071840;regulation of cell projection organization#GO:0031344;regulation of synaptic plasticity#GO:0048167 G-protein modulator#PC00022;GTPase-activating protein#PC00257 HUMAN|HGNC=26027|UniProtKB=Q9H0A8 Q9H0A8 COMMD4 PTHR16231:SF11 COMM DOMAIN-CONTAINING PROTEIN 4-8 FAMILY MEMBER COMM DOMAIN-CONTAINING PROTEIN 4 structural molecule activity#GO:0005198;protein complex scaffold activity#GO:0140378 response to peptide#GO:1901652;cell communication#GO:0007154;tumor necrosis factor-mediated signaling pathway#GO:0033209;cytokine-mediated signaling pathway#GO:0019221;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;response to cytokine#GO:0034097;response to chemical#GO:0042221;signal transduction#GO:0007165;cellular process#GO:0009987;response to tumor necrosis factor#GO:0034612 protein-containing complex#GO:0032991 HUMAN|HGNC=11241|UniProtKB=P17947 P17947 SPI1 PTHR11849:SF16 ETS TRANSCRIPTION FACTOR PU.1 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700 regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;developmental process#GO:0032502;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 DNA-binding transcription factor#PC00218;winged helix/forkhead transcription factor#PC00246 Interleukin signaling pathway#P00036>Ets#P00989 HUMAN|HGNC=30097|UniProtKB=O94913 O94913 PCF11 PTHR15921:SF3 PRE-MRNA CLEAVAGE COMPLEX II PRE-MRNA CLEAVAGE COMPLEX 2 PROTEIN PCF11 protein binding#GO:0005515;RNA binding#GO:0003723;RNA polymerase II complex binding#GO:0000993;mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;enzyme binding#GO:0019899;RNA polymerase core enzyme binding#GO:0043175;RNA polymerase binding#GO:0070063 nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;termination of RNA polymerase II transcription#GO:0006369;macromolecule metabolic process#GO:0043170;DNA-templated transcription termination#GO:0006353;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467 mRNA cleavage factor complex#GO:0005849;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HUMAN|HGNC=24820|UniProtKB=Q15884 Q15884 ENTREP1 PTHR17615:SF8 PROTEIN FAM189A ENDOSOMAL TRANSMEMBRANE EPSIN INTERACTOR 1 enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772 G protein-coupled receptor signaling pathway#GO:0007186;cytokine-mediated signaling pathway#GO:0019221;response to peptide#GO:1901652;localization#GO:0051179;chemokine-mediated signaling pathway#GO:0070098;cell communication#GO:0007154;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;signaling#GO:0023052;cellular response to chemokine#GO:1990869;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;endocytosis#GO:0006897;cell surface receptor signaling pathway#GO:0007166;transport#GO:0006810;receptor-mediated endocytosis#GO:0006898;establishment of localization#GO:0051234;import into cell#GO:0098657;signal transduction#GO:0007165;cellular process#GO:0009987;receptor internalization#GO:0031623;response to chemokine#GO:1990868;biological regulation#GO:0065007;response to chemical#GO:0042221;response to cytokine#GO:0034097;vesicle-mediated transport#GO:0016192 intracellular organelle#GO:0043229;endosome#GO:0005768;endosome membrane#GO:0010008;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;recycling endosome#GO:0055037;late endosome membrane#GO:0031902;early endosome membrane#GO:0031901;recycling endosome membrane#GO:0055038;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;membrane#GO:0016020;cell periphery#GO:0071944;cytoplasmic vesicle membrane#GO:0030659;late endosome#GO:0005770;endomembrane system#GO:0012505;plasma membrane#GO:0005886;cytoplasm#GO:0005737 HUMAN|HGNC=4556|UniProtKB=P36969 P36969 GPX4 PTHR11592:SF134 GLUTATHIONE PEROXIDASE PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE GPX4 oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on peroxide as acceptor#GO:0016684;peroxidase activity#GO:0004601;antioxidant activity#GO:0016209;catalytic activity#GO:0003824 monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;small molecule metabolic process#GO:0044281;oxoacid metabolic process#GO:0043436;cellular response to chemical stimulus#GO:0070887;cellular response to stress#GO:0033554;response to stress#GO:0006950;cellular process#GO:0009987;response to chemical#GO:0042221;cellular response to oxidative stress#GO:0034599;icosanoid metabolic process#GO:0006690;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;lipid metabolic process#GO:0006629;response to oxidative stress#GO:0006979;cellular response to chemical stress#GO:0062197 oxidoreductase#PC00176;peroxidase#PC00180 HUMAN|HGNC=9157|UniProtKB=P54317 P54317 PNLIPRP2 PTHR11610:SF165 LIPASE PANCREATIC LIPASE-RELATED PROTEIN 2 hydrolase activity, acting on ester bonds#GO:0016788;carboxylic ester hydrolase activity#GO:0052689;catalytic activity#GO:0003824;lipase activity#GO:0016298;hydrolase activity#GO:0016787 phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;lipid catabolic process#GO:0016042;phospholipid catabolic process#GO:0009395;catabolic process#GO:0009056;phospholipid metabolic process#GO:0006644;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;organophosphate catabolic process#GO:0046434 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 metabolite interconversion enzyme#PC00262;lipase#PC00143;hydrolase#PC00121 HUMAN|HGNC=9174|UniProtKB=P06746 P06746 POLB PTHR11276:SF42 DNA POLYMERASE TYPE-X FAMILY MEMBER DNA POLYMERASE BETA catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a nucleic acid#GO:0140640;nucleotidyltransferase activity#GO:0016779;transferase activity, transferring phosphorus-containing groups#GO:0016772;DNA polymerase activity#GO:0034061;catalytic activity, acting on DNA#GO:0140097;DNA-directed DNA polymerase activity#GO:0003887 response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;nucleic acid metabolic process#GO:0090304;base-excision repair#GO:0006284;primary metabolic process#GO:0044238;cellular response to stress#GO:0033554;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;response to stress#GO:0006950;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;double-strand break repair via nonhomologous end joining#GO:0006303;DNA damage response#GO:0006974;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-directed DNA polymerase#PC00018;DNA metabolism protein#PC00009 HUMAN|HGNC=2610|UniProtKB=P11509 P11509 CYP2A6 PTHR24300:SF180 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 2A6 binding#GO:0005488;tetrapyrrole binding#GO:0046906;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;heme binding#GO:0020037;monooxygenase activity#GO:0004497;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen#GO:0016712;oxidoreductase activity#GO:0016491 small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;xenobiotic metabolic process#GO:0006805;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;arachidonate metabolic process#GO:0019369;response to xenobiotic stimulus#GO:0009410;oxoacid metabolic process#GO:0043436;cellular response to chemical stimulus#GO:0070887;olefinic compound metabolic process#GO:0120254;response to chemical#GO:0042221;icosanoid metabolic process#GO:0006690;cellular response to xenobiotic stimulus#GO:0071466;long-chain fatty acid metabolic process#GO:0001676;cellular process#GO:0009987;secondary metabolic process#GO:0019748;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;unsaturated fatty acid metabolic process#GO:0033559;lipid metabolic process#GO:0006629 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229 oxygenase#PC00177;oxidoreductase#PC00176 Nicotine degradation#P05914>CYP2A6#P05984 HUMAN|HGNC=4748|UniProtKB=Q99880 Q99880 H2BC13 PTHR23428:SF190 HISTONE H2B HISTONE H2B TYPE 1-L response to stimulus#GO:0050896;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to bacterium#GO:0009617;immune system process#GO:0002376;defense response to bacterium#GO:0042742;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;immune response#GO:0006955;defense response to symbiont#GO:0140546;defense response to other organism#GO:0098542;response to other organism#GO:0051707;antimicrobial humoral response#GO:0019730;humoral immune response#GO:0006959;innate immune response#GO:0045087;antibacterial humoral response#GO:0019731;defense response#GO:0006952;response to external stimulus#GO:0009605 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=2742|UniProtKB=Q9UMR2 Q9UMR2 DDX19B PTHR47958:SF208 ATP-DEPENDENT RNA HELICASE DBP3 ATP-DEPENDENT RNA HELICASE DDX19B mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488;ATP-dependent activity#GO:0140657;RNA binding#GO:0003723;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;RNA helicase activity#GO:0003724;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543;helicase activity#GO:0004386;catalytic activity, acting on RNA#GO:0140098;isomerase activity#GO:0016853 nuclear export#GO:0051168;nuclear transport#GO:0051169;mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;nucleic acid transport#GO:0050657;localization#GO:0051179;nucleocytoplasmic transport#GO:0006913;mRNA transport#GO:0051028;establishment of RNA localization#GO:0051236;RNA transport#GO:0050658;RNA localization#GO:0006403;nucleobase-containing compound transport#GO:0015931;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;poly(A)+ mRNA export from nucleus#GO:0016973;transport#GO:0006810;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;metabolic process#GO:0008152;biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;establishment of localization in cell#GO:0051649;nitrogen compound transport#GO:0071705;macromolecule localization#GO:0033036 nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;ribonucleoprotein granule#GO:0035770;organelle#GO:0043226;supramolecular complex#GO:0099080;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic stress granule#GO:0010494;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228 RNA helicase#PC00032 HUMAN|HGNC=27310|UniProtKB=Q8NFG4 Q8NFG4 FLCN PTHR31441:SF4 FOLLICULIN FAMILY MEMBER FOLLICULIN GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047 regulation of DNA-templated transcription#GO:0006355;positive regulation of TOR signaling#GO:0032008;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of cell communication#GO:0010646;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092;positive regulation of signal transduction#GO:0009967;regulation of transforming growth factor beta receptor signaling pathway#GO:0017015;regulation of biosynthetic process#GO:0009889;regulation of TORC1 signaling#GO:1903432;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;positive regulation of response to stimulus#GO:0048584;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular response to growth factor stimulus#GO:0090287;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of signal transduction#GO:0009966;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of TORC1 signaling#GO:1904263;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;negative regulation of DNA-templated transcription#GO:0045892;positive regulation of signaling#GO:0023056;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of macromolecule biosynthetic process#GO:0010558;positive regulation of biological process#GO:0048518;regulation of TOR signaling#GO:0032006 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cytosol#GO:0005829;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HUMAN|HGNC=25148|UniProtKB=Q8NEG4 Q8NEG4 FAM83F PTHR16181:SF32 PROTEIN FAM83A-RELATED PROTEIN FAM83F binding#GO:0005488;kinase binding#GO:0019900;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;protein binding#GO:0005515 cell communication#GO:0007154;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789 HUMAN|HGNC=23113|UniProtKB=Q9HB65 Q9HB65 ELL3 PTHR23288:SF18 OCCLUDIN AND RNA POLYMERASE II ELONGATION FACTOR ELL RNA POLYMERASE II ELONGATION FACTOR ELL3 nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;snRNA metabolic process#GO:0016073;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;snRNA transcription by RNA polymerase II#GO:0042795;RNA biosynthetic process#GO:0032774;positive regulation of RNA metabolic process#GO:0051254;DNA-templated transcription#GO:0006351;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;transcription by RNA polymerase II#GO:0006366;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;macromolecule biosynthetic process#GO:0009059;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;nucleic acid biosynthetic process#GO:0141187;regulation of transcription elongation by RNA polymerase II#GO:0034243;regulation of DNA-templated transcription elongation#GO:0032784;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;RNA metabolic process#GO:0016070;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of DNA-templated transcription, elongation#GO:0032786;snRNA transcription#GO:0009301;metabolic process#GO:0008152;positive regulation of transcription by RNA polymerase II#GO:0045944;nucleobase-containing compound biosynthetic process#GO:0034654;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;gene expression#GO:0010467 transcription elongation factor complex#GO:0008023;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 general transcription factor#PC00259 HUMAN|HGNC=12406|UniProtKB=P50607 P50607 TUB PTHR16517:SF20 TUBBY-RELATED TUBBY PROTEIN HOMOLOG macromolecule localization#GO:0033036;localization#GO:0051179;protein localization to organelle#GO:0033365;protein localization to cilium#GO:0061512;intracellular protein localization#GO:0008104 cell projection#GO:0042995;membrane-bounded organelle#GO:0043227;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cilium#GO:0005929 scaffold/adaptor protein#PC00226 HUMAN|HGNC=24642|UniProtKB=Q9H1Z8 Q9H1Z8 ECRG4 PTHR31613:SF2 AUGURIN AUGURIN primary metabolic process#GO:0044238;cell cycle#GO:0007049;cellular response to stimulus#GO:0051716;modification-dependent protein catabolic process#GO:0019941;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;anatomical structure development#GO:0048856;protein metabolic process#GO:0019538;regulation of cell population proliferation#GO:0042127;system development#GO:0048731;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;developmental process#GO:0032502;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;cell cycle process#GO:0022402;regulation of biological process#GO:0050789;central nervous system development#GO:0007417;response to stimulus#GO:0050896;animal gross anatomical part developmental process#GO:0160108;modification-dependent macromolecule catabolic process#GO:0043632;anaphase-promoting complex-dependent catabolic process#GO:0031145;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;response to stress#GO:0006950;cellular process#GO:0009987;proteasomal protein catabolic process#GO:0010498;nervous system development#GO:0007399;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;multicellular organism development#GO:0007275 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=21040|UniProtKB=Q9UMY1 Q9UMY1 NOL7 PTHR32337:SF2 NUCLEOLAR PROTEIN 7 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN NOL7 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974 HUMAN|HGNC=20750|UniProtKB=Q8IVQ6 Q8IVQ6 ZDHHC21 PTHR22883:SF11 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE ZDHHC21 transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746;catalytic activity, acting on a protein#GO:0140096;palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 localization within membrane#GO:0051668;protein targeting to membrane#GO:0006612;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;establishment of protein localization#GO:0045184;cellular process#GO:0009987;establishment of protein localization to membrane#GO:0090150;protein targeting#GO:0006605 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 protein modifying enzyme#PC00260 HUMAN|HGNC=9455|UniProtKB=O75360 O75360 PROP1 PTHR47409:SF1 HOMEOBOX PROTEIN PROPHET OF PIT-1 HOMEOBOX PROTEIN PROPHET OF PIT-1 cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 transcription regulator complex#GO:0005667;protein-containing complex#GO:0032991 gene-specific transcriptional regulator#PC00264;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=23724|UniProtKB=Q14CB8 Q14CB8 ARHGAP19 PTHR14963:SF7 RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED RHO GTPASE-ACTIVATING PROTEIN 19 G-protein modulator#PC00022;GTPase-activating protein#PC00257 HUMAN|HGNC=3808|UniProtKB=Q13461 Q13461 FOXE3 PTHR11829:SF156 FORKHEAD BOX PROTEIN FORKHEAD BOX PROTEIN E3 DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of RNA metabolic process#GO:0051252;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 helix-turn-helix transcription factor#PC00116;gene-specific transcriptional regulator#PC00264;winged helix/forkhead transcription factor#PC00246 HUMAN|HGNC=3330|UniProtKB=O00423 O00423 EML1 PTHR13720:SF22 WD-40 REPEAT PROTEIN ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 1 microtubule binding#GO:0008017;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;protein binding#GO:0005515 cytoskeleton organization#GO:0007010;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;spindle#GO:0005819;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitotic spindle#GO:0072686;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630 microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=25675|UniProtKB=Q96FZ7 Q96FZ7 CHMP6 PTHR22761:SF5 CHARGED MULTIVESICULAR BODY PROTEIN CHARGED MULTIVESICULAR BODY PROTEIN 6 organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;multivesicular body sorting pathway#GO:0071985;cellular process#GO:0009987;nuclear membrane organization#GO:0071763;late endosome to vacuole transport via multivesicular body sorting pathway#GO:0032511;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;cellular component assembly#GO:0022607;endosome transport via multivesicular body sorting pathway#GO:0032509;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;intracellular transport#GO:0046907;transport#GO:0006810;vacuolar transport#GO:0007034;establishment of localization#GO:0051234;nucleus organization#GO:0006997;cellular component organization or biogenesis#GO:0071840;nuclear envelope organization#GO:0006998;vesicle organization#GO:0016050;vesicle budding from membrane#GO:0006900;endosomal transport#GO:0016197;cellular component organization#GO:0016043;membrane assembly#GO:0071709;late endosome to vacuole transport#GO:0045324;cellular localization#GO:0051641;localization#GO:0051179 endosome#GO:0005768;endosome membrane#GO:0010008;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;nucleus#GO:0005634;membrane#GO:0016020;vesicle membrane#GO:0012506;cytoplasm#GO:0005737;nuclear envelope#GO:0005635;late endosome#GO:0005770;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505 membrane traffic protein#PC00150 HUMAN|HGNC=13613|UniProtKB=Q969U6 Q969U6 FBXW5 PTHR20995:SF17 F-BOX/WD REPEAT-CONTAINING PROTEIN 5 F-BOX_WD REPEAT-CONTAINING PROTEIN 5 HUMAN|HGNC=30584|UniProtKB=P0DJJ0 P0DJJ0 SRGAP2C PTHR14166:SF6 SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 2-RELATED molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;enzyme activator activity#GO:0008047 negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of cellular component biogenesis#GO:0044087;animal gross anatomical part developmental process#GO:0160108;regulation of cell junction assembly#GO:1901888;regulation of synapse organization#GO:0050807;regulation of synapse structure or activity#GO:0050803;anatomical structure development#GO:0048856;regulation of cell motility#GO:2000145;regulation of biological quality#GO:0065008;system development#GO:0048731;multicellular organismal process#GO:0032501;regulation of synapse assembly#GO:0051963;nervous system development#GO:0007399;regulation of locomotion#GO:0040012;negative regulation of locomotion#GO:0040013;biological regulation#GO:0065007;negative regulation of cell motility#GO:2000146;negative regulation of cellular process#GO:0048523;negative regulation of cell migration#GO:0030336;regulation of cell migration#GO:0030334;developmental process#GO:0032502;multicellular organism development#GO:0007275 cell junction#GO:0030054;dendrite#GO:0030425;dendritic tree#GO:0097447;cellular anatomical structure#GO:0110165;synapse#GO:0045202;glutamatergic synapse#GO:0098978;neuron spine#GO:0044309;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;somatodendritic compartment#GO:0036477;postsynapse#GO:0098794;dendritic spine#GO:0043197;neuron projection#GO:0043005 G-protein modulator#PC00022;GTPase-activating protein#PC00257 PDGF signaling pathway#P00047>Rho#P01174 HUMAN|HGNC=28515|UniProtKB=Q96M61 Q96M61 MAGEB18 PTHR11736:SF23 MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN MELANOMA-ASSOCIATED ANTIGEN B18 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 scaffold/adaptor protein#PC00226 HUMAN|HGNC=11261|UniProtKB=P35326 P35326 SPRR2A PTHR48553:SF5 SMALL PROLINE-RICH PROTEIN 2E SMALL PROLINE-RICH PROTEIN 2A HUMAN|HGNC=8996|UniProtKB=O60331 O60331 PIP5K1C PTHR23086:SF26 PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE PHOSPHATIDYLINOSITOL 4-PHOSPHATE 5-KINASE TYPE-1 GAMMA lipid kinase activity#GO:0001727;phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;phosphatidylinositol kinase activity#GO:0052742;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824 glycerophospholipid metabolic process#GO:0006650;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058;organophosphate metabolic process#GO:0019637;glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987;metabolic process#GO:0008152;glycerophospholipid biosynthetic process#GO:0046474;lipid metabolic process#GO:0006629;glycerolipid metabolic process#GO:0046486;phospholipid biosynthetic process#GO:0008654;phospholipid metabolic process#GO:0006644;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;organophosphate biosynthetic process#GO:0090407;phosphatidylinositol phosphate biosynthetic process#GO:0046854 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 kinase#PC00137;transferase#PC00220 HUMAN|HGNC=25774|UniProtKB=Q96GX1 Q96GX1 TCTN2 PTHR14611:SF6 TECTONIC FAMILY MEMBER TECTONIC-2 protein localization to cilium#GO:0061512;signaling#GO:0023052;response to stimulus#GO:0050896;cell projection organization#GO:0030030;regulation of cellular process#GO:0050794;protein localization to organelle#GO:0033365;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular component organization#GO:0016043;cilium assembly#GO:0060271;smoothened signaling pathway#GO:0007224;cilium organization#GO:0044782;localization#GO:0051179;cell communication#GO:0007154;organelle assembly#GO:0070925;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cell projection assembly#GO:0030031;signal transduction#GO:0007165;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;macromolecule localization#GO:0033036;intracellular protein localization#GO:0008104;cellular component organization or biogenesis#GO:0071840;cell surface receptor signaling pathway#GO:0007166;plasma membrane bounded cell projection assembly#GO:0120031 ciliary transition zone#GO:0035869;cilium#GO:0005929;membrane-bounded organelle#GO:0043227;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995 HUMAN|HGNC=28238|UniProtKB=Q969Y0 Q969Y0 NXPE3 PTHR16165:SF9 NXPE FAMILY MEMBER NXPE FAMILY MEMBER 3 HUMAN|HGNC=25705|UniProtKB=Q8N5Z5 Q8N5Z5 KCTD17 PTHR14958:SF24 POTASSIUM CHANNEL TETRAMERISATION DOMAIN CONTAINING PROTEIN BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD17 protein binding#GO:0005515;binding#GO:0005488 regulation of cell projection assembly#GO:0060491;positive regulation of organelle organization#GO:0010638;protein metabolic process#GO:0019538;positive regulation of cellular component organization#GO:0051130;protein catabolic process#GO:0030163;positive regulation of cell projection organization#GO:0031346;modification-dependent macromolecule catabolic process#GO:0043632;regulation of cellular component biogenesis#GO:0044087;catabolic process#GO:0009056;regulation of cellular component organization#GO:0051128;regulation of plasma membrane bounded cell projection assembly#GO:0120032;regulation of cellular process#GO:0050794;modification-dependent protein catabolic process#GO:0019941;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;regulation of plasma membrane bounded cell projection organization#GO:0120035;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;regulation of cell projection organization#GO:0031344;regulation of cilium assembly#GO:1902017;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;biological regulation#GO:0065007;proteasomal protein catabolic process#GO:0010498;positive regulation of cellular component biogenesis#GO:0044089;positive regulation of biological process#GO:0048518;regulation of organelle assembly#GO:1902115;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cullin-RING ubiquitin ligase complex#GO:0031461;cytoplasm#GO:0005737;transferase complex#GO:1990234;catalytic complex#GO:1902494;Cul3-RING ubiquitin ligase complex#GO:0031463;ubiquitin ligase complex#GO:0000151;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HUMAN|HGNC=6376|UniProtKB=Q07444 Q07444 KLRC3 PTHR22800:SF239 C-TYPE LECTIN PROTEINS NKG2-E TYPE II INTEGRAL MEMBRANE PROTEIN transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;immune receptor activity#GO:0140375 positive regulation of response to external stimulus#GO:0032103;immune response-activating signaling pathway#GO:0002757;cell surface receptor signaling pathway#GO:0007166;immune effector process#GO:0002252;defense response to other organism#GO:0098542;regulation of response to external stimulus#GO:0032101;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;defense response to symbiont#GO:0140546;activation of immune response#GO:0002253;response to stress#GO:0006950;positive regulation of immune system process#GO:0002684;response to biotic stimulus#GO:0009607;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449;regulation of cell killing#GO:0031341;regulation of lymphocyte mediated immunity#GO:0002706;immune system process#GO:0002376;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;immune response-regulating signaling pathway#GO:0002764;natural killer cell mediated immunity#GO:0002228;regulation of biological process#GO:0050789;defense response#GO:0006952;response to external stimulus#GO:0009605;positive regulation of response to biotic stimulus#GO:0002833;innate immune response#GO:0045087;regulation of innate immune response#GO:0045088;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;positive regulation of defense response#GO:0031349;regulation of response to stress#GO:0080134;positive regulation of leukocyte mediated immunity#GO:0002705;response to other organism#GO:0051707;positive regulation of immune effector process#GO:0002699;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;regulation of natural killer cell mediated cytotoxicity#GO:0042269;positive regulation of response to stimulus#GO:0048584;positive regulation of innate immune response#GO:0045089;immune response#GO:0006955;positive regulation of cellular process#GO:0048522;positive regulation of natural killer cell mediated cytotoxicity#GO:0045954;activation of innate immune response#GO:0002218;regulation of leukocyte mediated cytotoxicity#GO:0001910;regulation of immune effector process#GO:0002697;cell communication#GO:0007154;positive regulation of lymphocyte mediated immunity#GO:0002708;regulation of defense response#GO:0031347;regulation of immune response#GO:0050776;immune response-activating cell surface receptor signaling pathway#GO:0002429;regulation of response to biotic stimulus#GO:0002831;positive regulation of natural killer cell mediated immunity#GO:0002717;response to external biotic stimulus#GO:0043207;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of natural killer cell mediated immunity#GO:0002715;cellular response to stimulus#GO:0051716;regulation of leukocyte mediated immunity#GO:0002703;innate immune response-activating signaling pathway#GO:0002758 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cell surface#GO:0009986;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090 HUMAN|HGNC=5581|UniProtKB=P01766 P01766 IGHV3-13 PTHR23266:SF277 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 3-13 binding#GO:0005488;antigen binding#GO:0003823 immune response#GO:0006955;adaptive immune response#GO:0002250;response to stimulus#GO:0050896;immune effector process#GO:0002252;immune system process#GO:0002376;immunoglobulin mediated immune response#GO:0016064;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=5359|UniProtKB=Q14197 Q14197 MRPL58 PTHR11075:SF54 PEPTIDE CHAIN RELEASE FACTOR LARGE RIBOSOMAL SUBUNIT PROTEIN ML62 catalytic activity, acting on a tRNA#GO:0140101;hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689;catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on ester bonds#GO:0016788;translation factor activity#GO:0180051;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640 translation release factor#PC00225 HUMAN|HGNC=28554|UniProtKB=Q6V702 Q6V702 CFAP299 PTHR33588:SF1 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 299 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 299 structural protein#PC00211 HUMAN|HGNC=26564|UniProtKB=Q5T1B0 Q5T1B0 AXDND1 PTHR23052:SF1 AXONEMAL DYNEIN LIGHT CHAIN DOMAIN-CONTAINING PROTEIN 1 AXONEMAL DYNEIN LIGHT CHAIN DOMAIN-CONTAINING PROTEIN 1 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=8521|UniProtKB=P32242 P32242 OTX1 PTHR45793:SF9 HOMEOBOX PROTEIN HOMEOBOX PROTEIN OTX1 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;central nervous system development#GO:0007417;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;animal gross anatomical part developmental process#GO:0160108;brain development#GO:0007420;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;head development#GO:0060322;nervous system development#GO:0007399;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;multicellular organism development#GO:0007275;regulation of biosynthetic process#GO:0009889;animal organ development#GO:0048513;regulation of gene expression#GO:0010468;developmental process#GO:0032502 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 Gonadotropin-releasing hormone receptor pathway#P06664>OTX#P06818 HUMAN|HGNC=25686|UniProtKB=Q9HAB8 Q9HAB8 PPCS PTHR12290:SF2 CORNICHON-RELATED PHOSPHOPANTOTHENATE--CYSTEINE LIGASE membrane traffic protein#PC00150 Coenzyme A biosynthesis#P02736>Pantothenate cysteine ligase#P02882 HUMAN|HGNC=28838|UniProtKB=Q68G74 Q68G74 LHX8 PTHR24208:SF117 LIM/HOMEOBOX PROTEIN LHX LIM_HOMEOBOX PROTEIN LHX8 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 central nervous system development#GO:0007417;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;forebrain development#GO:0030900;cell development#GO:0048468;regulation of biological process#GO:0050789;neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;nervous system development#GO:0007399;head development#GO:0060322;cellular process#GO:0009987;multicellular organism development#GO:0007275;animal organ development#GO:0048513;neuron differentiation#GO:0030182;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;brain development#GO:0007420;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;developmental process#GO:0032502;central nervous system neuron differentiation#GO:0021953 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119 HUMAN|HGNC=8686|UniProtKB=Q9Y5E8 Q9Y5E8 PCDHB15 PTHR24028:SF97 CADHERIN-87A PROTOCADHERIN BETA-15 cell adhesion#GO:0007155;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 cell adhesion molecule#PC00069;cadherin#PC00057 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HUMAN|HGNC=21107|UniProtKB=Q5TB80 Q5TB80 CEP162 PTHR34031:SF1 CENTROSOMAL PROTEIN OF 162 KDA CENTROSOMAL PROTEIN OF 162 KDA plasma membrane bounded cell projection organization#GO:0120036;cell projection organization#GO:0030030;cellular component assembly#GO:0022607;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cilium organization#GO:0044782;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection assembly#GO:0120031;organelle assembly#GO:0070925 microtubule cytoskeleton#GO:0015630;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;supramolecular complex#GO:0099080;ciliary plasm#GO:0097014;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232;centriole#GO:0005814;cytoplasm#GO:0005737;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;organelle lumen#GO:0043233;cytoplasmic microtubule#GO:0005881;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;axonemal microtubule#GO:0005879;nuclear lumen#GO:0031981;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;cilium#GO:0005929;intracellular organelle#GO:0043229;microtubule#GO:0005874;axoneme#GO:0005930;membrane-bounded organelle#GO:0043227;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=40038|UniProtKB=P0DJ07 P0DJ07 PET100 PTHR33968:SF1 PROTEIN PET100 HOMOLOG, MITOCHONDRIAL PROTEIN PET100 HOMOLOG, MITOCHONDRIAL cellular component organization or biogenesis#GO:0071840;respiratory chain complex IV assembly#GO:0008535;protein-containing complex organization#GO:0043933;chaperone-mediated protein complex assembly#GO:0051131;mitochondrial respiratory chain complex IV assembly#GO:0033617;cytochrome complex assembly#GO:0017004;cellular component assembly#GO:0022607;mitochondrial respiratory chain complex assembly#GO:0033108;mitochondrion organization#GO:0007005;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=8518|UniProtKB=Q5XKR4 Q5XKR4 OTP PTHR46770:SF1 HOMEOBOX PROTEIN ORTHOPEDIA HOMEOBOX PROTEIN ORTHOPEDIA binding#GO:0005488;nucleic acid binding#GO:0003676;DNA binding#GO:0003677 animal gross anatomical part developmental process#GO:0160108;neuron differentiation#GO:0030182;generation of neurons#GO:0048699;developmental process#GO:0032502;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;anatomical structure development#GO:0048856;system development#GO:0048731;neurogenesis#GO:0022008;cellular process#GO:0009987;cell differentiation#GO:0030154;multicellular organismal process#GO:0032501;nervous system development#GO:0007399 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=12625|UniProtKB=Q96RU2 Q96RU2 USP28 PTHR24006:SF678 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 28 hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;cysteine-type deubiquitinase activity#GO:0004843;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of cell cycle#GO:0051726;signaling#GO:0023052;negative regulation of biological process#GO:0048519;regulation of cell cycle phase transition#GO:1901987;negative regulation of cell cycle phase transition#GO:1901988;signal transduction in response to DNA damage#GO:0042770;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of biological quality#GO:0065008;cellular response to stress#GO:0033554;DNA damage checkpoint signaling#GO:0000077;cell cycle checkpoint signaling#GO:0000075;regulation of cell cycle process#GO:0010564;biological regulation#GO:0065007;DNA integrity checkpoint signaling#GO:0031570;response to stress#GO:0006950;signal transduction#GO:0007165;regulation of protein stability#GO:0031647;cellular process#GO:0009987;negative regulation of cell cycle#GO:0045786;negative regulation of cellular process#GO:0048523;DNA damage response#GO:0006974;negative regulation of cell cycle process#GO:0010948 nucleus#GO:0005634;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 cysteine protease#PC00081;protease#PC00190 HUMAN|HGNC=11501|UniProtKB=O43761 O43761 SYNGR3 PTHR10838:SF8 SYNAPTOGYRIN SYNAPTOGYRIN-3 regulated exocytosis#GO:0045055;transport#GO:0006810;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;secretion#GO:0046903;establishment of localization#GO:0051234;secretion by cell#GO:0032940;exocytosis#GO:0006887;synaptic vesicle membrane organization#GO:0048499;cellular component organization#GO:0016043;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;export from cell#GO:0140352 cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;synaptic vesicle#GO:0008021;vesicle#GO:0031982;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;transport vesicle#GO:0030133;cytoplasm#GO:0005737;secretory vesicle#GO:0099503;presynapse#GO:0098793;neuromuscular junction#GO:0031594;cell junction#GO:0030054 membrane traffic protein#PC00150;membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=2511|UniProtKB=Q9UI47 Q9UI47 CTNNA3 PTHR18914:SF21 ALPHA CATENIN CATENIN ALPHA-3 binding#GO:0005488;actin binding#GO:0003779;actin filament binding#GO:0051015;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;beta-catenin binding#GO:0008013 cell-cell adhesion#GO:0098609;cell adhesion#GO:0007155;cellular process#GO:0009987;cell motility#GO:0048870;cell migration#GO:0016477 cell junction#GO:0030054;extrinsic component of membrane#GO:0019898;extrinsic component of plasma membrane#GO:0019897;adherens junction#GO:0005912;intercalated disc#GO:0014704;cell-cell contact zone#GO:0044291;anchoring junction#GO:0070161;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane protein complex#GO:0098796;cell-cell junction#GO:0005911;membrane#GO:0016020;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944 non-motor actin binding protein#PC00165 Cadherin signaling pathway#P00012>alpha-catenin#P00467;Wnt signaling pathway#P00057>alpha-catenin#P01471 HUMAN|HGNC=28928|UniProtKB=Q86Y46 Q86Y46 KRT73 PTHR45616:SF31 GATA-TYPE DOMAIN-CONTAINING PROTEIN KERATIN, TYPE II CYTOSKELETAL 73 structural molecule activity#GO:0005198 epidermis development#GO:0008544;developmental process#GO:0032502;cellular component organization or biogenesis#GO:0071840;animal organ development#GO:0048513;cellular developmental process#GO:0048869;organelle organization#GO:0006996;cellular process#GO:0009987;epithelium development#GO:0060429;epithelial cell differentiation#GO:0030855;tissue development#GO:0009888;multicellular organismal process#GO:0032501;epidermal cell differentiation#GO:0009913;cytoskeleton organization#GO:0007010;skin development#GO:0043588;intermediate filament-based process#GO:0045103;animal gross anatomical part developmental process#GO:0160108;keratinocyte differentiation#GO:0030216;intermediate filament organization#GO:0045109;anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;cellular component organization#GO:0016043;cell differentiation#GO:0030154;intermediate filament cytoskeleton organization#GO:0045104 intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;intermediate filament#GO:0005882;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 HUMAN|HGNC=4751|UniProtKB=P33778 P33778 H2BC3 PTHR23428:SF374 HISTONE H2B HISTONE H2B TYPE 1-B response to external stimulus#GO:0009605;defense response#GO:0006952;antibacterial humoral response#GO:0019731;innate immune response#GO:0045087;antimicrobial humoral response#GO:0019730;humoral immune response#GO:0006959;response to other organism#GO:0051707;defense response to other organism#GO:0098542;defense response to symbiont#GO:0140546;immune response#GO:0006955;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;defense response to bacterium#GO:0042742;response to bacterium#GO:0009617;immune system process#GO:0002376;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to stimulus#GO:0050896 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=22199|UniProtKB=O75128 O75128 COBL PTHR47008:SF1 PROTEIN CORDON-BLEU PROTEIN CORDON-BLEU protein binding#GO:0005515;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;actin monomer binding#GO:0003785 cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;actin polymerization or depolymerization#GO:0008154;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;actin filament organization#GO:0007015;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;actin filament polymerization#GO:0030041;actin cytoskeleton organization#GO:0030036;protein-containing complex assembly#GO:0065003;protein polymerization#GO:0051258;cellular component organization#GO:0016043;supramolecular fiber organization#GO:0097435;actin filament-based process#GO:0030029 plasma membrane bounded cell projection#GO:0120025;distal axon#GO:0150034;neuronal cell body#GO:0043025;dendrite#GO:0030425;growth cone#GO:0030426;dendritic tree#GO:0097447;axon#GO:0030424;intracellular anatomical structure#GO:0005622;site of polarized growth#GO:0030427;membrane#GO:0016020;cell periphery#GO:0071944;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;cytoskeleton#GO:0005856;ruffle#GO:0001726;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;actin cytoskeleton#GO:0015629;cell body#GO:0044297;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cell projection#GO:0042995;axonal growth cone#GO:0044295;intracellular organelle#GO:0043229;supramolecular fiber#GO:0099512;cell leading edge#GO:0031252;neuron projection#GO:0043005;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;perinuclear region of cytoplasm#GO:0048471;actin filament#GO:0005884 HUMAN|HGNC=34513|UniProtKB=A6NHJ4 A6NHJ4 ZNF860 PTHR24377:SF409 IP01015P-RELATED ZINC FINGER PROTEIN 860 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=4861|UniProtKB=Q9NRZ9 Q9NRZ9 HELLS PTHR47161:SF1 LYMPHOID-SPECIFIC HELICASE LYMPHOID-SPECIFIC HELICASE catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;molecular adaptor activity#GO:0060090;chromatin-protein adaptor activity#GO:0140463;catalytic activity, acting on DNA#GO:0140097;ATP-dependent activity#GO:0140657;protein-macromolecule adaptor activity#GO:0030674;ATP-dependent activity, acting on DNA#GO:0008094 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;epigenetic regulation of gene expression#GO:0040029;negative regulation of macromolecule metabolic process#GO:0010605;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;chromatin organization#GO:0006325;negative regulation of biosynthetic process#GO:0009890;DNA repair#GO:0006281;negative regulation of cellular process#GO:0048523;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;heterochromatin formation#GO:0031507;cellular response to stimulus#GO:0051716;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;recombinational repair#GO:0000725;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;response to stress#GO:0006950;cellular process#GO:0009987;cellular component assembly#GO:0022607;heterochromatin organization#GO:0070828;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;DNA recombination#GO:0006310;cellular component organization or biogenesis#GO:0071840;DNA methylation-dependent constitutive heterochromatin formation#GO:0006346;negative regulation of gene expression, epigenetic#GO:0045814;constitutive heterochromatin formation#GO:0140719;double-strand break repair#GO:0006302;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;double-strand break repair via homologous recombination#GO:0000724;response to stimulus#GO:0050896;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;cellular response to stress#GO:0033554 intracellular organelle#GO:0043229;chromosome, centromeric region#GO:0000775;intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687;membrane-bounded organelle#GO:0043227;heterochromatin#GO:0000792;membraneless organelle#GO:0043228;nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226 Wnt signaling pathway#P00057>SWI/SNF#P01435 HUMAN|HGNC=6336|UniProtKB=P43632 P43632 KIR2DS4 PTHR11738:SF168 MHC CLASS I NK CELL RECEPTOR IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN-RELATED signaling receptor activity#GO:0038023;immune receptor activity#GO:0140375;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 signaling#GO:0023052;immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;response to stimulus#GO:0050896;cellular process#GO:0009987;immune response-regulating signaling pathway#GO:0002764;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;regulation of response to stimulus#GO:0048583;regulation of immune response#GO:0050776 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=12238|UniProtKB=A0A1B0GX95 A0A1B0GX95 TRBV7-4 PTHR23268:SF20 T-CELL RECEPTOR BETA CHAIN T CELL RECEPTOR BETA VARIABLE 7-4-RELATED cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=4238|UniProtKB=Q5VTD9 Q5VTD9 GFI1B PTHR24393:SF146 ZINC FINGER PROTEIN ZINC FINGER PROTEIN GFI-1B DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;sequence-specific DNA binding#GO:0043565;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;DNA-binding transcription activator activity#GO:0001216;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific double-stranded DNA binding#GO:1990837;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of RNA metabolic process#GO:0051252;regulation of hemopoiesis#GO:1903706;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of multicellular organismal development#GO:2000026;regulation of developmental process#GO:0050793;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of cell differentiation#GO:0045595;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of cell development#GO:0060284;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of multicellular organismal process#GO:0051239;regulation of nucleobase-containing compound metabolic process#GO:0019219 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=26758|UniProtKB=Q7Z3I7 Q7Z3I7 ZNF572 PTHR24399:SF73 ZINC FINGER AND BTB DOMAIN-CONTAINING ZINC FINGER PROTEIN 572 DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulator activity#GO:0140110;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription repressor activity#GO:0001217;sequence-specific DNA binding#GO:0043565;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837 regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;regulation of multicellular organismal process#GO:0051239;regulation of cytokine production#GO:0001817;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605 nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218 HUMAN|HGNC=29103|UniProtKB=O75185 O75185 ATP2C2 PTHR42861:SF23 CALCIUM-TRANSPORTING ATPASE CALCIUM-TRANSPORTING ATPASE TYPE 2C MEMBER 2 ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;P-type ion transporter activity#GO:0015662;active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399;metal ion transmembrane transporter activity#GO:0046873 transport#GO:0006810;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;establishment of localization#GO:0051234;intracellular calcium ion homeostasis#GO:0006874;intracellular chemical homeostasis#GO:0055082;calcium ion transport#GO:0006816;cellular homeostasis#GO:0019725;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;calcium ion homeostasis#GO:0055074;inorganic ion homeostasis#GO:0098771;transition metal ion transport#GO:0000041;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;calcium ion transmembrane transport#GO:0070588;intracellular monoatomic ion homeostasis#GO:0006873;metal ion transport#GO:0030001;homeostatic process#GO:0042592 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;endomembrane system#GO:0012505;endoplasmic reticulum#GO:0005783;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588 primary active transporter#PC00068 HUMAN|HGNC=5731|UniProtKB=P0DP09 P0DP09 IGKV1-13 PTHR23267:SF480 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN KAPPA VARIABLE 1-13-RELATED response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=17859|UniProtKB=Q5SRE5 Q5SRE5 NUP188 PTHR31431:SF1 NUCLEOPORIN NUP188 HOMOLOG NUCLEOPORIN NUP188 structural molecule activity#GO:0005198;structural constituent of nuclear pore#GO:0017056 protein localization to nucleus#GO:0034504;nitrogen compound transport#GO:0071705;import into nucleus#GO:0051170;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;intracellular protein localization#GO:0008104;protein localization to organelle#GO:0033365;RNA localization#GO:0006403;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;establishment of RNA localization#GO:0051236;nucleocytoplasmic transport#GO:0006913;nucleic acid transport#GO:0050657;cellular localization#GO:0051641;localization#GO:0051179;protein transport#GO:0015031;protein import into nucleus#GO:0006606;nuclear export#GO:0051168;nuclear transport#GO:0051169 intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;nuclear pore#GO:0005643;membrane-bounded organelle#GO:0043227;organelle envelope#GO:0031967;nucleus#GO:0005634;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635 transporter#PC00227 HUMAN|HGNC=15455|UniProtKB=O43462 O43462 MBTPS2 PTHR13325:SF3 PROTEASE M50 MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE 2 PROTEASE MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE-2 PROTEASE catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222 regulation of response to stress#GO:0080134;metabolic process#GO:0008152;proteolysis#GO:0006508;regulation of response to stimulus#GO:0048583;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;regulation of cellular response to stress#GO:0080135;primary metabolic process#GO:0044238;cellular process#GO:0009987;regulation of response to endoplasmic reticulum stress#GO:1905897;membrane protein proteolysis#GO:0033619;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protease#PC00190;protein modifying enzyme#PC00260;metalloprotease#PC00153 HUMAN|HGNC=3145|UniProtKB=Q9NQA5 Q9NQA5 TRPV5 PTHR10582:SF11 TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 5 monoatomic cation channel activity#GO:0005261;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;calcium channel activity#GO:0005262;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085 localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;calcium ion transmembrane transport#GO:0070588;calcium ion import#GO:0070509;import across plasma membrane#GO:0098739;metal ion transport#GO:0030001;inorganic ion import across plasma membrane#GO:0099587;transport#GO:0006810;renal absorption#GO:0070293;establishment of localization#GO:0051234;calcium ion transmembrane import into cytosol#GO:0097553;import into cell#GO:0098657;system process#GO:0003008;inorganic cation import across plasma membrane#GO:0098659;calcium ion transport#GO:0006816;renal system process#GO:0003014;cellular process#GO:0009987;multicellular organismal process#GO:0032501;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HUMAN|HGNC=20246|UniProtKB=Q8WUD1 Q8WUD1 RAB2B PTHR47979:SF50 DRAB11-RELATED RAS-RELATED PROTEIN RAB-2B nucleoside phosphate binding#GO:1901265;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;guanyl nucleotide binding#GO:0019001;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;ion binding#GO:0043167;GTPase activity#GO:0003924;small molecule binding#GO:0036094;anion binding#GO:0043168;hydrolase activity#GO:0016787;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111 transport#GO:0006810;regulation of transport#GO:0051049;regulation of localization#GO:0032879;establishment of localization#GO:0051234;positive regulation of transport#GO:0051050;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of secretion by cell#GO:1903532;cellular process#GO:0009987;biological regulation#GO:0065007;vesicle-mediated transport#GO:0016192;positive regulation of secretion#GO:0051047;regulation of secretion by cell#GO:1903530;regulation of exocytosis#GO:0017157;regulation of secretion#GO:0051046;localization#GO:0051179;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;regulation of cellular process#GO:0050794 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 small GTPase#PC00208;G-protein#PC00020 HUMAN|HGNC=19942|UniProtKB=O43617 O43617 TRAPPC3 PTHR13048:SF2 TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 3 TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 3 guanyl-nucleotide exchange factor activity#GO:0005085;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810;Golgi vesicle transport#GO:0048193;intracellular transport#GO:0046907;vesicle-mediated transport#GO:0016192;intra-Golgi vesicle-mediated transport#GO:0006891;cellular process#GO:0009987;establishment of localization in cell#GO:0051649 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;Golgi apparatus#GO:0005794;cis-Golgi network#GO:0005801;vesicle tethering complex#GO:0099023;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular protein-containing complex#GO:0140535;cytosol#GO:0005829;membrane#GO:0016020;TRAPP complex#GO:0030008;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505 HUMAN|HGNC=20816|UniProtKB=Q96QT6 Q96QT6 PHF12 PTHR46309:SF28 PHD FINGER PROTEIN 12 PHD FINGER PROTEIN 12 transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of macromolecule metabolic process#GO:0010605;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789 chromosome#GO:0005694;organelle lumen#GO:0043233;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;Sin3-type complex#GO:0070822;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;histone deacetylase complex#GO:0000118;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;chromatin#GO:0000785;protein-containing complex#GO:0032991;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=17234|UniProtKB=Q9BXX3 Q9BXX3 ANKRD30A PTHR24147:SF63 ANKYRIN REPEAT DOMAIN 36-RELATED ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 30A HUMAN|HGNC=3721|UniProtKB=Q13451 Q13451 FKBP5 PTHR10516:SF26 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP5 catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;isomerase activity#GO:0016853;peptidyl-prolyl cis-trans isomerase activity#GO:0003755;cis-trans isomerase activity#GO:0016859 biosynthetic process#GO:0009058;protein folding#GO:0006457;gene expression#GO:0010467;protein maturation#GO:0051604;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152 chaperone#PC00072 HUMAN|HGNC=19987|UniProtKB=Q5JZY3 Q5JZY3 EPHA10 PTHR46877:SF16 EPH RECEPTOR A5 EPHRIN TYPE-A RECEPTOR 10 transmembrane signaling receptor activity#GO:0004888;phosphotransferase activity, alcohol group as acceptor#GO:0016773;molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714;protein kinase activity#GO:0004672;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein tyrosine kinase activity#GO:0004713;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;signaling receptor activity#GO:0038023;transmembrane receptor protein kinase activity#GO:0019199 neurogenesis#GO:0022008;neuron projection guidance#GO:0097485;cellular developmental process#GO:0048869;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;axon development#GO:0061564;axon guidance#GO:0007411;system development#GO:0048731;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;ephrin receptor signaling pathway#GO:0048013;cell projection morphogenesis#GO:0048858;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell surface receptor signaling pathway#GO:0007166;neuron differentiation#GO:0030182;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;cellular process#GO:0009987;signal transduction#GO:0007165;neuron projection development#GO:0031175;axonogenesis#GO:0007409;neuron development#GO:0048666;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;signaling#GO:0023052;cell morphogenesis#GO:0000902;response to stimulus#GO:0050896;cell differentiation#GO:0030154;cell projection organization#GO:0030030;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cellular component organization#GO:0016043 cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;cell projection#GO:0042995;somatodendritic compartment#GO:0036477;membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005;dendrite#GO:0030425;dendritic tree#GO:0097447 transmembrane signal receptor#PC00197 HUMAN|HGNC=3247|UniProtKB=Q08426 Q08426 EHHADH PTHR23309:SF9 3-HYDROXYACYL-COA DEHYROGENASE PEROXISOMAL BIFUNCTIONAL ENZYME catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614 lipid catabolic process#GO:0016042;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;monocarboxylic acid catabolic process#GO:0072329;fatty acid oxidation#GO:0019395;lipid metabolic process#GO:0006629;fatty acid beta-oxidation#GO:0006635;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;lipid modification#GO:0030258;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;small molecule catabolic process#GO:0044282;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;oxoacid metabolic process#GO:0043436;fatty acid catabolic process#GO:0009062;lipid oxidation#GO:0034440 microbody#GO:0042579;peroxisome#GO:0005777;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 dehydrogenase#PC00092;oxidoreductase#PC00176 HUMAN|HGNC=21253|UniProtKB=Q8TAF8 Q8TAF8 LHFPL5 PTHR12489:SF18 LIPOMA HMGIC FUSION PARTNER-LIKE PROTEIN LHFPL TETRASPAN SUBFAMILY MEMBER 5 PROTEIN multicellular organismal process#GO:0032501;response to stimulus#GO:0050896;sensory perception of sound#GO:0007605;response to mechanical stimulus#GO:0009612;response to abiotic stimulus#GO:0009628;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;system process#GO:0003008;response to external stimulus#GO:0009605;nervous system process#GO:0050877;sensory perception#GO:0007600;sensory perception of mechanical stimulus#GO:0050954;detection of mechanical stimulus#GO:0050982 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=9273|UniProtKB=O60437 O60437 PPL PTHR23169:SF10 ENVOPLAKIN PERIPLAKIN response to stimulus#GO:0050896;intermediate filament cytoskeleton organization#GO:0045104;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;response to wounding#GO:0009611;response to stress#GO:0006950;organelle organization#GO:0006996;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;wound healing#GO:0042060;intermediate filament-based process#GO:0045103 cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;organelle#GO:0043226;supramolecular complex#GO:0099080;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;intermediate filament#GO:0005882;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 intermediate filament binding protein#PC00130;intermediate filament#PC00129 HUMAN|HGNC=5299|UniProtKB=Q13639 Q13639 HTR4 PTHR24247:SF179 5-HYDROXYTRYPTAMINE RECEPTOR 5-HYDROXYTRYPTAMINE RECEPTOR 4 molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;neurotransmitter receptor activity#GO:0030594;transmembrane signaling receptor activity#GO:0004888;G protein-coupled amine receptor activity#GO:0008227 cell communication#GO:0007154;trans-synaptic signaling#GO:0099537;G protein-coupled receptor signaling pathway#GO:0007186;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;anterograde trans-synaptic signaling#GO:0098916;signaling#GO:0023052;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;synaptic signaling#GO:0099536;chemical synaptic transmission#GO:0007268;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165 dendrite#GO:0030425;dendritic tree#GO:0097447;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;plasma membrane bounded cell projection#GO:0120025 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GsPCR#P00720;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;5HT4 type receptor mediated signaling pathway#P04376>5HT4 Receptor#P04427 HUMAN|HGNC=12294|UniProtKB=A0A0C4DH27 A0A0C4DH27 TRGV8 PTHR19256:SF54 T-CELL RECEPTOR GAMMA CHAIN T CELL RECEPTOR GAMMA VARIABLE 8 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=20721|UniProtKB=O75132 O75132 ZBED4 PTHR46481:SF15 ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4 ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4 HUMAN|HGNC=10566|UniProtKB=P57086 P57086 SCAND1 PTHR45935:SF23 PROTEIN ZBED8-RELATED SCAN DOMAIN-CONTAINING PROTEIN 1 HUMAN|HGNC=6172|UniProtKB=P46977 P46977 STT3A PTHR13872:SF43 DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3A transferase activity#GO:0016740;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;glycosyltransferase activity#GO:0016757 protein N-linked glycosylation#GO:0006487;protein modification process#GO:0036211;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;post-translational protein modification#GO:0043687;biosynthetic process#GO:0009058;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170 membrane protein complex#GO:0098796;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;oligosaccharyltransferase complex#GO:0008250;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasm#GO:0005737;endoplasmic reticulum membrane#GO:0005789;transferase complex#GO:1990234;endoplasmic reticulum#GO:0005783;endoplasmic reticulum protein-containing complex#GO:0140534;organelle membrane#GO:0031090 glycosyltransferase#PC00111 HUMAN|HGNC=7534|UniProtKB=P50539 P50539 MXI1 PTHR11969:SF13 MAX DIMERIZATION, MAD MAX-INTERACTING PROTEIN 1 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=28296|UniProtKB=Q96EX3 Q96EX3 DYNC2I2 PTHR12442:SF26 DYNEIN INTERMEDIATE CHAIN CYTOPLASMIC DYNEIN 2 INTERMEDIATE CHAIN 2 binding#GO:0005488;protein binding#GO:0005515 transport#GO:0006810;intracellular transport#GO:0046907;microtubule-based process#GO:0007017;transport along microtubule#GO:0010970;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;organelle organization#GO:0006996;plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton-dependent intracellular transport#GO:0030705;microtubule-based transport#GO:0099111;cilium organization#GO:0044782;cellular localization#GO:0051641;localization#GO:0051179;cellular component organization#GO:0016043;intraciliary transport#GO:0042073;microtubule-based movement#GO:0007018;cell projection organization#GO:0030030 plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;dynein complex#GO:0030286;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cilium#GO:0005929;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;ciliary plasm#GO:0097014;cytoplasmic dynein complex#GO:0005868;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856 microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=11917|UniProtKB=P20333 P20333 TNFRSF1B PTHR47386:SF1 TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 1B TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 1B molecular transducer activity#GO:0060089;protein binding#GO:0005515;tumor necrosis factor binding#GO:0043120;transmembrane signaling receptor activity#GO:0004888;death receptor activity#GO:0005035;binding#GO:0005488;cytokine binding#GO:0019955;signaling receptor activity#GO:0038023 regulation of catabolic process#GO:0009894;positive regulation of catabolic process#GO:0009896;regulation of biosynthetic process#GO:0009889;DNA damage response#GO:0006974;positive regulation of developmental process#GO:0051094;regulation of cell differentiation#GO:0045595;regulation of response to stimulus#GO:0048583;regulation of system process#GO:0044057;biological regulation#GO:0065007;negative regulation of response to stimulus#GO:0048585;regulation of lymphocyte proliferation#GO:0050670;positive regulation of cellular process#GO:0048522;regulation of cell development#GO:0060284;regulation of cytokine production#GO:0001817;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of cell population proliferation#GO:0042127;regulation of immune effector process#GO:0002697;regulation of immune response#GO:0050776;regulation of defense response#GO:0031347;regulation of T cell proliferation#GO:0042129;regulation of macromolecule metabolic process#GO:0060255;regulation of immune system process#GO:0002682;negative regulation of inflammatory response#GO:0050728;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;programmed cell death#GO:0012501;regulation of neurogenesis#GO:0050767;regulation of leukocyte proliferation#GO:0070663;regulation of proteolysis#GO:0030162;positive regulation of cell differentiation#GO:0045597;positive regulation of cell development#GO:0010720;positive regulation of macromolecule metabolic process#GO:0010604;regulation of response to external stimulus#GO:0032101;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of mononuclear cell proliferation#GO:0032944;regulation of lymphocyte mediated immunity#GO:0002706;regulation of cytokine production involved in immune response#GO:0002718;response to stimulus#GO:0050896;extrinsic apoptotic signaling pathway#GO:0097191;regulation of biological process#GO:0050789;apoptotic process#GO:0006915;positive regulation of multicellular organismal process#GO:0051240;negative regulation of biological process#GO:0048519;regulation of gene expression#GO:0010468;apoptotic signaling pathway#GO:0097190;regulation of response to stress#GO:0080134;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of protein catabolic process#GO:0045732;regulation of protein catabolic process#GO:0042176;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;regulation of nervous system development#GO:0051960;regulation of inflammatory response#GO:0050727;regulation of developmental process#GO:0050793;positive regulation of neurogenesis#GO:0050769;negative regulation of defense response#GO:0031348;regulation of leukocyte mediated immunity#GO:0002703;cell death#GO:0008219;cell surface receptor signaling pathway#GO:0007166;negative regulation of response to external stimulus#GO:0032102;regulation of multicellular organismal process#GO:0051239;regulation of T cell activation#GO:0050863;intrinsic apoptotic signaling pathway in response to DNA damage#GO:0008630;regulation of protein metabolic process#GO:0051246;response to stress#GO:0006950;positive regulation of metabolic process#GO:0009893;intrinsic apoptotic signaling pathway#GO:0097193;cellular response to stress#GO:0033554;positive regulation of protein metabolic process#GO:0051247;signaling#GO:0023052;regulation of lymphocyte activation#GO:0051249;positive regulation of nervous system development#GO:0051962;regulation of cell activation#GO:0050865;regulation of multicellular organismal development#GO:2000026;regulation of leukocyte activation#GO:0002694 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 Apoptosis signaling pathway#P00006>TNFR2#P00287 HUMAN|HGNC=1638|UniProtKB=P15812 P15812 CD1E PTHR16675:SF146 MHC CLASS I-RELATED T-CELL SURFACE GLYCOPROTEIN CD1E, MEMBRANE-ASSOCIATED antigen binding#GO:0003823;binding#GO:0005488;lipid binding#GO:0008289 regulation of leukocyte mediated immunity#GO:0002703;regulation of biological process#GO:0050789;positive regulation of adaptive immune response#GO:0002821;response to stimulus#GO:0050896;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of immune response#GO:0050776;regulation of cell killing#GO:0031341;regulation of lymphocyte mediated immunity#GO:0002706;immune system process#GO:0002376;regulation of leukocyte mediated cytotoxicity#GO:0001910;positive regulation of lymphocyte mediated immunity#GO:0002708;antigen processing and presentation#GO:0019882;regulation of immune effector process#GO:0002697;positive regulation of cellular process#GO:0048522;immune response#GO:0006955;positive regulation of biological process#GO:0048518;positive regulation of immune system process#GO:0002684;biological regulation#GO:0065007;positive regulation of immune effector process#GO:0002699;positive regulation of response to stimulus#GO:0048584;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;positive regulation of leukocyte mediated immunity#GO:0002705 plasma membrane#GO:0005886;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;side of membrane#GO:0098552;extracellular region#GO:0005576;external side of plasma membrane#GO:0009897 defense/immunity protein#PC00090;major histocompatibility complex protein#PC00149 HUMAN|HGNC=1735|UniProtKB=Q16543 Q16543 CDC37 PTHR12800:SF3 CDC37-RELATED HSP90 CO-CHAPERONE CDC37 protein binding#GO:0005515;heat shock protein binding#GO:0031072;binding#GO:0005488 protein maturation#GO:0051604;gene expression#GO:0010467;regulation of response to external stimulus#GO:0032101;regulation of signal transduction#GO:0009966;biosynthetic process#GO:0009058;biological regulation#GO:0065007;regulation of response to cytokine stimulus#GO:0060759;regulation of protein stability#GO:0031647;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;regulation of innate immune response#GO:0045088;macromolecule metabolic process#GO:0043170;regulation of cytokine-mediated signaling pathway#GO:0001959;protein stabilization#GO:0050821;metabolic process#GO:0008152;regulation of response to stress#GO:0080134;regulation of response to stimulus#GO:0048583;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of response to biotic stimulus#GO:0002831;protein folding#GO:0006457;regulation of cell communication#GO:0010646;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;protein metabolic process#GO:0019538;regulation of biological quality#GO:0065008;regulation of immune response#GO:0050776;regulation of signaling#GO:0023051;regulation of defense response#GO:0031347 protein folding chaperone complex#GO:0101031;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 chaperone#PC00072 HUMAN|HGNC=4878|UniProtKB=P06865 P06865 HEXA PTHR22600:SF39 BETA-HEXOSAMINIDASE BETA-HEXOSAMINIDASE SUBUNIT ALPHA hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798 carbohydrate derivative catabolic process#GO:1901136;liposaccharide metabolic process#GO:1903509;catabolic process#GO:0009056;glycolipid metabolic process#GO:0006664;primary metabolic process#GO:0044238;sphingolipid catabolic process#GO:0030149;glycosaminoglycan metabolic process#GO:0030203;protein N-linked glycosylation#GO:0006487;ceramide metabolic process#GO:0006672;protein metabolic process#GO:0019538;aminoglycan metabolic process#GO:0006022;biosynthetic process#GO:0009058;lipid catabolic process#GO:0016042;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;glycoprotein biosynthetic process#GO:0009101;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;glycoprotein metabolic process#GO:0009100;lipid metabolic process#GO:0006629;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152 organelle#GO:0043226;cellular anatomical structure#GO:0110165;vacuole#GO:0005773;plasma membrane#GO:0005886;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;lysosome#GO:0005764;cell periphery#GO:0071944;lytic vacuole#GO:0000323;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;extracellular region#GO:0005576 glycosidase#PC00110 HUMAN|HGNC=1445|UniProtKB=P0DP24 P0DP24 CALM2 PTHR23050:SF383 CALCIUM BINDING PROTEIN CALMODULIN-2 molecular function activator activity#GO:0140677;cation binding#GO:0043169;metal ion binding#GO:0046872;enzyme regulator activity#GO:0030234;calcium ion binding#GO:0005509;kinase activator activity#GO:0019209;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;protein kinase regulator activity#GO:0019887;protein kinase activator activity#GO:0030295;enzyme activator activity#GO:0008047;protein serine/threonine kinase activator activity#GO:0043539 response to metal ion#GO:0010038;regulation of monoatomic cation transmembrane transport#GO:1904062;regulation of release of sequestered calcium ion into cytosol#GO:0051279;calcium-mediated signaling#GO:0019722;regulation of transport#GO:0051049;regulation of localization#GO:0032879;regulation of monoatomic ion transmembrane transport#GO:0034765;cellular process#GO:0009987;signal transduction#GO:0007165;detection of stimulus#GO:0051606;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;regulation of calcium ion transport#GO:0051924;regulation of monoatomic ion transport#GO:0043269;response to chemical#GO:0042221;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;response to calcium ion#GO:0051592;cellular response to stimulus#GO:0051716;detection of chemical stimulus#GO:0009593;regulation of biological process#GO:0050789;calcineurin-mediated signaling#GO:0097720;regulation of transmembrane transport#GO:0034762;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of metal ion transport#GO:0010959 membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;centrosome#GO:0005813;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;myelin sheath#GO:0043209;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;microtubule cytoskeleton#GO:0015630;nucleus#GO:0005634 calcium-binding protein#PC00060;calmodulin-related#PC00061 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Calmodulin#P00755;T cell activation#P00053>Calmodulin#P01305;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Phosphorylase b kinase#P00716;B cell activation#P00010>Calmodulin#P00375 HUMAN|HGNC=28228|UniProtKB=Q96DD0 Q96DD0 LRRC39 PTHR45752:SF6 LEUCINE-RICH REPEAT-CONTAINING LEUCINE-RICH REPEAT-CONTAINING PROTEIN 39 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007 scaffold/adaptor protein#PC00226 HUMAN|HGNC=8820|UniProtKB=P01213 P01213 PDYN PTHR11438:SF4 PROENKEPHALIN PROENKEPHALIN-B protein binding#GO:0005515;molecular function activator activity#GO:0140677;signaling receptor binding#GO:0005102;binding#GO:0005488;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;G protein-coupled receptor binding#GO:0001664 cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;neuropeptide signaling pathway#GO:0007218;sensory perception of pain#GO:0019233;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;nervous system process#GO:0050877;sensory perception#GO:0007600;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signal transduction#GO:0007165;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;system process#GO:0003008 cell body#GO:0044297;vesicle#GO:0031982;intracellular vesicle#GO:0097708;organelle lumen#GO:0043233;neuronal cell body#GO:0043025;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;secretory vesicle#GO:0099503;membrane-enclosed lumen#GO:0031974;somatodendritic compartment#GO:0036477;cytoplasm#GO:0005737;endomembrane system#GO:0012505 neuropeptide#PC00162;peptide hormone#PC00179;intercellular signal molecule#PC00207 Enkephalin release#P05913>Enkephalin#P05976;Opioid prodynorphin pathway#P05916>prodynorphin#P05997;Opioid prodynorphin pathway#P05916>dynorphin#P06003;Enkephalin release#P05913>preproenkephalin#G06045;Enkephalin release#P05913>preproenkephalin mRNA#G06046;Opioid prodynorphin pathway#P05916>preprodynorphin#G06049;Opioid proenkephalin pathway#P05915>Enkephalin#P05991;Opioid prodynorphin pathway#P05916>preprodynorphin#G06047 HUMAN|HGNC=21165|UniProtKB=Q9Y3L5 Q9Y3L5 RAP2C PTHR24070:SF200 RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY RAS-RELATED PROTEIN RAP-2C ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818 cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;intracellular signal transduction#GO:0035556;regulation of cell motility#GO:2000145;cell communication#GO:0007154;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of locomotion#GO:0040012;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;negative regulation of locomotion#GO:0040013;small GTPase-mediated signal transduction#GO:0007264;negative regulation of cell motility#GO:2000146;regulation of cell migration#GO:0030334;negative regulation of cellular process#GO:0048523;negative regulation of cell migration#GO:0030336 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 small GTPase#PC00208 Integrin signalling pathway#P00034>Rap1#P00906 HUMAN|HGNC=25157|UniProtKB=Q96ES6 Q96ES6 SLC33A2 PTHR12778:SF10 SOLUTE CARRIER FAMILY 33 ACETYL-COA TRANSPORTER -RELATED SOLUTE CARRIER FAMILY 33 MEMBER 2 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 membrane#GO:0016020;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258;transporter#PC00227 HUMAN|HGNC=5465|UniProtKB=P08069 P08069 IGF1R PTHR24416:SF106 TYROSINE-PROTEIN KINASE RECEPTOR INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR catalytic activity, acting on a protein#GO:0140096;transmembrane receptor protein kinase activity#GO:0019199;signaling receptor activity#GO:0038023;protein tyrosine kinase activity#GO:0004713;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transmembrane receptor protein tyrosine kinase activity#GO:0004714;molecular transducer activity#GO:0060089;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 signaling#GO:0023052;cellular response to hormone stimulus#GO:0032870;positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051897;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;insulin-like growth factor receptor signaling pathway#GO:0048009;carbohydrate homeostasis#GO:0033500;regulation of biological process#GO:0050789;response to hexose#GO:0009746;response to endogenous stimulus#GO:0009719;response to carbohydrate#GO:0009743;intracellular glucose homeostasis#GO:0001678;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;insulin receptor signaling pathway#GO:0008286;response to oxygen-containing compound#GO:1901700;regulation of intracellular signal transduction#GO:1902531;cellular response to chemical stimulus#GO:0070887;response to monosaccharide#GO:0034284;response to chemical#GO:0042221;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;response to hormone#GO:0009725;glucose homeostasis#GO:0042593;regulation of JNK cascade#GO:0046328;chemical homeostasis#GO:0048878;cell surface receptor signaling pathway#GO:0007166;regulation of MAPK cascade#GO:0043408;cellular response to glucose stimulus#GO:0071333;regulation of cell communication#GO:0010646;cellular response to peptide hormone stimulus#GO:0071375;homeostatic process#GO:0042592;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;response to insulin#GO:0032868;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;response to nitrogen compound#GO:1901698;regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051896;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;response to peptide hormone#GO:0043434;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;response to glucose#GO:0009749;cellular response to nitrogen compound#GO:1901699;positive regulation of response to stimulus#GO:0048584;positive regulation of cellular process#GO:0048522;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;positive regulation of MAPK cascade#GO:0043410;cellular response to insulin stimulus#GO:0032869;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533 plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cell periphery#GO:0071944;neuron projection#GO:0043005;membrane#GO:0016020;protein kinase complex#GO:1902911;signaling receptor complex#GO:0043235;transferase complex#GO:1990234;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;catalytic complex#GO:1902494;axon#GO:0030424;transferase complex, transferring phosphorus-containing groups#GO:0061695 transmembrane signal receptor#PC00197 Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>INSR IGF-R IRR#P00885;Gonadotropin-releasing hormone receptor pathway#P06664>IGF-1R#P06703;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>INSR IGF-R IRR#P00895;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>Insulin IGF#P00882 HUMAN|HGNC=3700|UniProtKB=P07954 P07954 FH PTHR11444:SF1 ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE FUMARATE HYDRATASE, MITOCHONDRIAL catalytic activity#GO:0003824;hydro-lyase activity#GO:0016836;lyase activity#GO:0016829;carbon-oxygen lyase activity#GO:0016835 generation of precursor metabolites and energy#GO:0006091;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;aerobic respiration#GO:0009060;cellular respiration#GO:0045333;energy derivation by oxidation of organic compounds#GO:0015980;cellular process#GO:0009987;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;tricarboxylic acid cycle#GO:0006099;small molecule metabolic process#GO:0044281 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 lyase#PC00144 TCA cycle#P00051>Fumarase#P01271 HUMAN|HGNC=611|UniProtKB=P55056 P55056 APOC4 PTHR32288:SF0 APOLIPOPROTEIN C-IV APOLIPOPROTEIN C-IV lipid homeostasis#GO:0055088;triglyceride homeostasis#GO:0070328;chemical homeostasis#GO:0048878;cellular process#GO:0009987;lipid storage#GO:0019915;homeostatic process#GO:0042592 high-density lipoprotein particle#GO:0034364;plasma lipoprotein particle#GO:0034358;lipoprotein particle#GO:1990777;protein-lipid complex#GO:0032994;extracellular protein-containing complex#GO:0140392;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;very-low-density lipoprotein particle#GO:0034361 apolipoprotein#PC00052 HUMAN|HGNC=6692|UniProtKB=Q07954 Q07954 LRP1 PTHR24270:SF23 LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROLOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1 binding#GO:0005488;protein binding#GO:0005515 catabolic process#GO:0009056;multicellular organismal process#GO:0032501;vesicle-mediated transport#GO:0016192;endocytosis#GO:0006897;cellular process#GO:0009987;receptor-mediated endocytosis#GO:0006898;localization#GO:0051179;import into cell#GO:0098657;establishment of localization#GO:0051234;transport#GO:0006810;metabolic process#GO:0008152;phagocytosis#GO:0006909 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transfer/carrier protein#PC00219;apolipoprotein#PC00052 Alzheimer disease-presenilin pathway#P00004>LRP#P00150;Alzheimer disease-presenilin pathway#P00004>LRP transmembrane fragment#P00152;Alzheimer disease-presenilin pathway#P00004>LRP intracellular fragment#P00173;Alzheimer disease-presenilin pathway#P00004>LRP N-terminal fragment#P00169;Alzheimer disease-presenilin pathway#P00004>LRP C-terminal fragment#P00112 HUMAN|HGNC=10759|UniProtKB=Q9Y6X1 Q9Y6X1 SERP1 PTHR15601:SF14 STRESS ASSOCIATED ENDOPLASMIC RETICULUM PROTEIN SERP1/RAMP4 STRESS-ASSOCIATED ENDOPLASMIC RETICULUM PROTEIN 1 response to endoplasmic reticulum stress#GO:0034976;cellular response to unfolded protein#GO:0034620;cellular response to stress#GO:0033554;cellular response to topologically incorrect protein#GO:0035967;cell communication#GO:0007154;response to unfolded protein#GO:0006986;intracellular signal transduction#GO:0035556;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;response to topologically incorrect protein#GO:0035966;signaling#GO:0023052;endoplasmic reticulum unfolded protein response#GO:0030968;response to stress#GO:0006950;signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 chaperone#PC00072 HUMAN|HGNC=25249|UniProtKB=Q5FWF4 Q5FWF4 ZRANB3 PTHR45766:SF3 DNA ANNEALING HELICASE AND ENDONUCLEASE ZRANB3 FAMILY MEMBER DNA ANNEALING HELICASE AND ENDONUCLEASE ZRANB3 nucleic acid binding#GO:0003676;binding#GO:0005488;single-stranded DNA binding#GO:0003697;ATP-dependent activity#GO:0140657;DNA binding#GO:0003677;ATP-dependent activity, acting on DNA#GO:0008094;catalytic activity#GO:0003824;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;macromolecular conformation isomerase activity#GO:0120543;catalytic activity, acting on DNA#GO:0140097;isomerase activity#GO:0016853 cellular process#GO:0009987;response to stress#GO:0006950;nucleobase-containing compound metabolic process#GO:0006139;replication fork processing#GO:0031297;DNA damage response#GO:0006974;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;macromolecule metabolic process#GO:0043170;cellular response to stimulus#GO:0051716;DNA replication#GO:0006260;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;DNA-templated DNA replication#GO:0006261 DNA metabolism protein#PC00009 HUMAN|HGNC=7907|UniProtKB=Q7Z494 Q7Z494 NPHP3 PTHR45641:SF21 TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870) NEPHROCYSTIN-3 kidney development#GO:0001822;renal system development#GO:0072001;regionalization#GO:0003002;tissue development#GO:0009888;multicellular organismal process#GO:0032501;epithelium development#GO:0060429;determination of bilateral symmetry#GO:0009855;specification of symmetry#GO:0009799;left/right pattern formation#GO:0060972;developmental process#GO:0032502;animal organ development#GO:0048513;multicellular organism development#GO:0007275;morphogenesis of an epithelium#GO:0002009;anatomical structure morphogenesis#GO:0009653;determination of left/right symmetry#GO:0007368;animal organ morphogenesis#GO:0009887;animal gross anatomical part developmental process#GO:0160108;pattern specification process#GO:0007389;anatomical structure development#GO:0048856;tissue morphogenesis#GO:0048729;system development#GO:0048731 cilium#GO:0005929;ciliary base#GO:0097546;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=29613|UniProtKB=Q7Z4W2 Q7Z4W2 LYZL2 PTHR11407:SF62 LYSOZYME C LYSOZYME-LIKE PROTEIN 1-RELATED hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;peptidoglycan muralytic activity#GO:0061783;catalytic activity#GO:0003824;lysozyme activity#GO:0003796;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787 glycosidase#PC00110 HUMAN|HGNC=12968|UniProtKB=Q9ULX5 Q9ULX5 RNF112 PTHR10751:SF1 GUANYLATE BINDING PROTEIN RING FINGER PROTEIN 112 hydrolase activity, acting on acid anhydrides#GO:0016817;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787 endomembrane system organization#GO:0010256;cellular component organization or biogenesis#GO:0071840;endoplasmic reticulum organization#GO:0007029;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043 heterotrimeric G-protein#PC00117;G-protein#PC00020 HUMAN|HGNC=22004|UniProtKB=A6NGB9 A6NGB9 WIPF3 PTHR23331:SF4 CXYORF1 WAS_WASL-INTERACTING PROTEIN FAMILY MEMBER 3 cellular component organization#GO:0016043;endocytic recycling#GO:0032456;actin nucleation#GO:0045010;actin cytoskeleton organization#GO:0030036;export from cell#GO:0140352;cytosolic transport#GO:0016482;localization within membrane#GO:0051668;actin filament-based process#GO:0030029;localization#GO:0051179;secretion#GO:0046903;cellular localization#GO:0051641;secretion by cell#GO:0032940;supramolecular fiber organization#GO:0097435;retrograde transport, endosome to Golgi#GO:0042147;organelle organization#GO:0006996;establishment of localization in cell#GO:0051649;Arp2/3 complex-mediated actin nucleation#GO:0034314;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;cytoskeleton organization#GO:0007010;intracellular transport#GO:0046907;transport#GO:0006810;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;endosomal transport#GO:0016197;actin filament organization#GO:0007015;vesicle-mediated transport to the plasma membrane#GO:0098876;exocytosis#GO:0006887 intracellular organelle#GO:0043229;endosome#GO:0005768;recycling endosome#GO:0055037;membrane-bounded organelle#GO:0043227;early endosome#GO:0005769;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 membrane traffic protein#PC00150 HUMAN|HGNC=2892|UniProtKB=Q9UBU2 Q9UBU2 DKK2 PTHR12113:SF12 DICKKOPF3-LIKE 3 DICKKOPF-RELATED PROTEIN 2 molecular function inhibitor activity#GO:0140678;molecular function regulator activity#GO:0098772;signaling receptor inhibitor activity#GO:0030547;protein binding#GO:0005515;signaling receptor regulator activity#GO:0030545;binding#GO:0005488 negative regulation of signaling#GO:0023057;negative regulation of canonical Wnt signaling pathway#GO:0090090;regulation of signaling#GO:0023051;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of canonical Wnt signaling pathway#GO:0060828;negative regulation of response to stimulus#GO:0048585;negative regulation of Wnt signaling pathway#GO:0030178;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 membrane trafficking regulatory protein#PC00151;membrane traffic protein#PC00150 HUMAN|HGNC=3555|UniProtKB=P07148 P07148 FABP1 PTHR11955:SF96 FATTY ACID BINDING PROTEIN FATTY ACID-BINDING PROTEIN, LIVER organic acid binding#GO:0043177;small molecule binding#GO:0036094;binding#GO:0005488;carboxylic acid binding#GO:0031406;anion binding#GO:0043168;ion binding#GO:0043167;lipid binding#GO:0008289;fatty acid binding#GO:0005504 lipid transport#GO:0006869;macromolecule localization#GO:0033036;monocarboxylic acid transport#GO:0015718;localization#GO:0051179;fatty acid transport#GO:0015908;establishment of localization#GO:0051234;carboxylic acid transport#GO:0046942;transport#GO:0006810;organic acid transport#GO:0015849;lipid localization#GO:0010876 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 transfer/carrier protein#PC00219 HUMAN|HGNC=19849|UniProtKB=Q8N1H7 Q8N1H7 SIX6OS1 PTHR35449:SF1 PROTEIN SIX6OS1 PROTEIN SIX6OS1 male gamete generation#GO:0048232;nucleobase-containing compound metabolic process#GO:0006139;macromolecule metabolic process#GO:0043170;DNA double-strand break processing#GO:0000729;meiotic nuclear division#GO:0140013;cellular developmental process#GO:0048869;meiotic chromosome segregation#GO:0045132;chromosome organization#GO:0051276;DNA repair#GO:0006281;developmental process#GO:0032502;spermatogenesis#GO:0007283;DNA damage response#GO:0006974;reproductive process#GO:0022414;homologous recombination#GO:0035825;cell cycle#GO:0007049;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;developmental process involved in reproduction#GO:0003006;reciprocal homologous recombination#GO:0140527;germ cell development#GO:0007281;cellular response to stimulus#GO:0051716;anatomical structure development#GO:0048856;organelle fission#GO:0048285;multicellular organismal reproductive process#GO:0048609;meiosis I cell cycle process#GO:0061982;sexual reproduction#GO:0019953;homologous chromosome pairing at meiosis#GO:0007129;oogenesis#GO:0048477;organelle organization#GO:0006996;response to stress#GO:0006950;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;homologous chromosome segregation#GO:0045143;double-strand break repair#GO:0006302;metabolic process#GO:0008152;chromosome organization involved in meiotic cell cycle#GO:0070192;meiotic cell cycle#GO:0051321;DNA metabolic process#GO:0006259;DNA recombination#GO:0006310;chromosome segregation#GO:0007059;cell differentiation#GO:0030154;response to stimulus#GO:0050896;gamete generation#GO:0007276;cell development#GO:0048468;cellular process involved in reproduction in multicellular organism#GO:0022412;meiotic cell cycle process#GO:1903046;nuclear chromosome segregation#GO:0098813;cellular component organization#GO:0016043;meiosis I#GO:0007127;cell cycle process#GO:0022402;nuclear division#GO:0000280;cellular response to stress#GO:0033554;reciprocal meiotic recombination#GO:0007131 central element#GO:0000801;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;chromosome#GO:0005694;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;condensed chromosome#GO:0000793;synaptonemal complex#GO:0000795;condensed nuclear chromosome#GO:0000794;membraneless organelle#GO:0043228;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;synaptonemal structure#GO:0099086 HUMAN|HGNC=3800|UniProtKB=Q12948 Q12948 FOXC1 PTHR11829:SF68 FORKHEAD BOX PROTEIN FORKHEAD BOX PROTEIN C1 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;regulation of RNA metabolic process#GO:0051252;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;developmental process#GO:0032502 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=11324|UniProtKB=P43308 P43308 SSR2 PTHR12861:SF3 TRANSLOCON-ASSOCIATED PROTEIN, BETA SUBUNIT PRECURSOR TRAP-BETA SIGNAL SEQUENCE RECEPTOR BETA SUBUNIT TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT BETA membrane traffic protein#PC00150 HUMAN|HGNC=4232|UniProtKB=P39905 P39905 GDNF PTHR12173:SF1 GDNF SUBFAMILY OF TGF-BETA FAMILY GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;receptor ligand activity#GO:0048018;growth factor activity#GO:0008083;signaling receptor regulator activity#GO:0030545 regulation of cellular process#GO:0050794;cell projection organization#GO:0030030;response to stimulus#GO:0050896;cell differentiation#GO:0030154;cell development#GO:0048468;signaling#GO:0023052;cellular component organization#GO:0016043;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;neuron development#GO:0048666;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;neuron projection development#GO:0031175;cellular process#GO:0009987;signal transduction#GO:0007165;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;neurogenesis#GO:0022008;cell surface receptor signaling pathway#GO:0007166;developmental process#GO:0032502;neuron differentiation#GO:0030182 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 neurotrophic factor#PC00163;growth factor#PC00112;intercellular signal molecule#PC00207 TGF-beta signaling pathway#P00052>TGFbeta#P01286 HUMAN|HGNC=11214|UniProtKB=Q9NPE6 Q9NPE6 SPAG4 PTHR12911:SF16 SAD1/UNC-84-LIKE PROTEIN-RELATED SPERM-ASSOCIATED ANTIGEN 4 PROTEIN protein-membrane adaptor activity#GO:0043495;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;organelle envelope#GO:0031967;membrane protein complex#GO:0098796;membrane#GO:0016020 microtubule or microtubule-binding cytoskeletal protein#PC00157;cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HUMAN|HGNC=23015|UniProtKB=Q96MK3 Q96MK3 FAM20A PTHR12450:SF12 DENTIN MATRIX PROTEIN 4 PROTEIN FAM20 PSEUDOKINASE FAM20A kinase activator activity#GO:0019209;molecular function activator activity#GO:0140677;phosphotransferase activity, alcohol group as acceptor#GO:0016773;enzyme regulator activity#GO:0030234;protein kinase activator activity#GO:0030295;transferase activity, transferring phosphorus-containing groups#GO:0016772;enzyme activator activity#GO:0008047;protein serine/threonine kinase activator activity#GO:0043539;transferase activity#GO:0016740;catalytic activity#GO:0003824;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;protein kinase regulator activity#GO:0019887 odontogenesis#GO:0042476;odontogenesis of dentin-containing tooth#GO:0042475;tissue development#GO:0009888;animal organ morphogenesis#GO:0009887;anatomical structure morphogenesis#GO:0009653;amelogenesis#GO:0097186;anatomical structure formation involved in morphogenesis#GO:0048646;anatomical structure development#GO:0048856;animal organ development#GO:0048513;biomineral tissue development#GO:0031214;developmental process#GO:0032502;animal gross anatomical part developmental process#GO:0160108;enamel mineralization#GO:0070166 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;Golgi apparatus#GO:0005794;extracellular region#GO:0005576;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=25120|UniProtKB=Q2T9K0 Q2T9K0 TMEM44 PTHR16201:SF53 SEVEN TRANSMEMBRANE PROTEIN 1-RELATED TRANSMEMBRANE PROTEIN 44 amino acid transmembrane transporter activity#GO:0015171;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;carboxylic acid transmembrane transporter activity#GO:0046943;basic amino acid transmembrane transporter activity#GO:0015174;L-amino acid transmembrane transporter activity#GO:0015179 cellular process#GO:0009987;nitrogen compound transport#GO:0071705;L-amino acid transport#GO:0015807;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;establishment of localization#GO:0051234;vacuolar transmembrane transport#GO:0034486;chemical homeostasis#GO:0048878;amino acid transport#GO:0006865;organic acid transport#GO:0015849;transport#GO:0006810;carboxylic acid transport#GO:0046942;carboxylic acid transmembrane transport#GO:1905039;homeostatic process#GO:0042592;L-alpha-amino acid transmembrane transport#GO:1902475;amino acid transmembrane transport#GO:0003333;transmembrane transport#GO:0055085;localization#GO:0051179 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;lysosome#GO:0005764;lytic vacuole membrane#GO:0098852;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;vacuole#GO:0005773;cytoplasm#GO:0005737;lysosomal membrane#GO:0005765;membrane#GO:0016020;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;lytic vacuole#GO:0000323;vacuolar membrane#GO:0005774 HUMAN|HGNC=10699|UniProtKB=O76054 O76054 SEC14L2 PTHR23324:SF90 SEC14 RELATED PROTEIN SEC14-LIKE PROTEIN 2 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 transfer/carrier protein#PC00219 HUMAN|HGNC=30211|UniProtKB=Q709F0 Q709F0 ACAD11 PTHR48083:SF42 MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED ACYL-COA DEHYDROGENASE FAMILY MEMBER 11 catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;oxidoreductase activity#GO:0016491 catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;small molecule catabolic process#GO:0044282;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;lipid oxidation#GO:0034440;fatty acid catabolic process#GO:0009062;oxoacid metabolic process#GO:0043436;monocarboxylic acid catabolic process#GO:0072329;carboxylic acid catabolic process#GO:0046395;lipid catabolic process#GO:0016042;cellular process#GO:0009987;lipid modification#GO:0030258;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;fatty acid oxidation#GO:0019395;fatty acid beta-oxidation#GO:0006635;lipid metabolic process#GO:0006629 mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 dehydrogenase#PC00092 HUMAN|HGNC=9538|UniProtKB=P40306 P40306 PSMB10 PTHR11599:SF41 PROTEASOME SUBUNIT ALPHA/BETA PROTEASOME SUBUNIT BETA TYPE-10 catalytic activity#GO:0003824;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096 modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;endopeptidase complex#GO:1905369;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;proteasome complex#GO:0000502;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;peptidase complex#GO:1905368;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 protein modifying enzyme#PC00260;protease#PC00190 Parkinson disease#P00049>20S proteasome#P01227 HUMAN|HGNC=30285|UniProtKB=Q7L099 Q7L099 RUFY3 PTHR45956:SF1 RUN AND FYVE DOMAIN-CONTAINING PROTEIN 2-LIKE PROTEIN PROTEIN RUFY3 regulation of axonogenesis#GO:0050770;regulation of anatomical structure morphogenesis#GO:0022603;regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of cell projection organization#GO:0031344;biological regulation#GO:0065007;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of biological process#GO:0050789;regulation of neuron projection development#GO:0010975 cell projection#GO:0042995;neuronal cell body#GO:0043025;somatodendritic compartment#GO:0036477;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;neuron projection#GO:0043005;cell body#GO:0044297;intracellular anatomical structure#GO:0005622;axon#GO:0030424;dendritic tree#GO:0097447;dendrite#GO:0030425 HUMAN|HGNC=3576|UniProtKB=Q9Y5Q0 Q9Y5Q0 FADS3 PTHR19353:SF11 FATTY ACID DESATURASE 2 FATTY ACID DESATURASE 3 oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705 primary metabolic process#GO:0044238;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;cellular process#GO:0009987 membrane#GO:0016020;cellular anatomical structure#GO:0110165 oxidoreductase#PC00176 HUMAN|HGNC=13728|UniProtKB=Q86Y34 Q86Y34 ADGRG3 PTHR12011:SF285 ADHESION G-PROTEIN COUPLED RECEPTOR ADHESION G PROTEIN-COUPLED RECEPTOR G3 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=8952|UniProtKB=P50452 P50452 SERPINB8 PTHR11461:SF166 SERINE PROTEASE INHIBITOR, SERPIN SERPIN B8 enzyme inhibitor activity#GO:0004857;endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;peptidase regulator activity#GO:0061134;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;serine-type endopeptidase inhibitor activity#GO:0004867 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;extracellular region#GO:0005576 protease inhibitor#PC00191 HUMAN|HGNC=16471|UniProtKB=Q9BXY5 Q9BXY5 CAPS2 PTHR34524:SF3 CALCYPHOSIN CALCYPHOSIN-2 calmodulin-related#PC00061;calcium-binding protein#PC00060 HUMAN|HGNC=12241|UniProtKB=A0A0K0K1E9 A0A0K0K1E9 TRBV7-7 PTHR23268:SF20 T-CELL RECEPTOR BETA CHAIN T CELL RECEPTOR BETA VARIABLE 7-4-RELATED response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=10359|UniProtKB=P83881 P83881 RPL36A PTHR10369:SF6 60S RIBOSOMAL PROTEIN L36A/L44 LARGE RIBOSOMAL SUBUNIT PROTEIN EL42 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;translation#GO:0006412;metabolic process#GO:0008152;biosynthetic process#GO:0009058;cytoplasmic translation#GO:0002181;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238 cytosolic large ribosomal subunit#GO:0022625;cytosolic ribosome#GO:0022626;cytosol#GO:0005829;ribosome#GO:0005840;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202 HUMAN|HGNC=3944|UniProtKB=Q92837 Q92837 FRAT1 PTHR35154:SF1 GBP PROTEIN PROTO-ONCOGENE FRAT1 positive regulation of response to stimulus#GO:0048584;positive regulation of Wnt signaling pathway#GO:0030177;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of canonical Wnt signaling pathway#GO:0060828;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of canonical Wnt signaling pathway#GO:0090263;regulation of response to stimulus#GO:0048583;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=992|UniProtKB=Q07817 Q07817 BCL2L1 PTHR11256:SF12 BCL-2 RELATED BCL-2-LIKE PROTEIN 1 channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 cell surface receptor signaling pathway#GO:0007166;regulation of apoptotic process#GO:0042981;cellular component organization or biogenesis#GO:0071840;positive regulation of apoptotic process#GO:0043065;positive regulation of biological process#GO:0048518;negative regulation of programmed cell death#GO:0043069;signal transduction#GO:0007165;cellular process#GO:0009987;organelle organization#GO:0006996;intrinsic apoptotic signaling pathway in response to DNA damage#GO:0008630;response to stress#GO:0006950;mitochondrion organization#GO:0007005;apoptotic mitochondrial changes#GO:0008637;cellular response to stress#GO:0033554;intrinsic apoptotic signaling pathway#GO:0097193;regulation of biological process#GO:0050789;apoptotic process#GO:0006915;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;cellular component organization#GO:0016043;signaling#GO:0023052;response to stimulus#GO:0050896;extrinsic apoptotic signaling pathway#GO:0097191;positive regulation of programmed cell death#GO:0043068;release of cytochrome c from mitochondria#GO:0001836;DNA damage response#GO:0006974;negative regulation of cellular process#GO:0048523;apoptotic signaling pathway#GO:0097190;positive regulation of cellular process#GO:0048522;biological regulation#GO:0065007;negative regulation of apoptotic process#GO:0043066;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;cell death#GO:0008219;cellular response to stimulus#GO:0051716;programmed cell death#GO:0012501;regulation of cellular process#GO:0050794 mitochondrial outer membrane#GO:0005741;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane#GO:0016020;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;organelle outer membrane#GO:0031968;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;outer membrane#GO:0019867;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle envelope#GO:0031967;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 CCKR signaling map#P06959>BCL2L1#P07117;Apoptosis signaling pathway#P00006>Bcl-xL#P00257;Apoptosis signaling pathway#P00006>Bcl-xS#P00323 HUMAN|HGNC=18296|UniProtKB=Q9NY27 Q9NY27 PPP4R2 PTHR16487:SF0 PPP4R2-RELATED PROTEIN SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 2 enzyme regulator activity#GO:0030234;phosphatase regulator activity#GO:0019208;protein phosphatase regulator activity#GO:0019888;molecular function regulator activity#GO:0098772 organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;protein serine/threonine phosphatase complex#GO:0008287;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 phosphatase modulator#PC00184 HUMAN|HGNC=8681|UniProtKB=Q9UN67 Q9UN67 PCDHB10 PTHR24028:SF54 CADHERIN-87A PROTOCADHERIN BETA-10 cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 cadherin#PC00057;cell adhesion molecule#PC00069 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HUMAN|HGNC=24350|UniProtKB=Q9H2F9 Q9H2F9 CCDC68 PTHR23171:SF3 GDOWN1 COILED-COIL DOMAIN-CONTAINING PROTEIN 68 nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle lumen#GO:0043233;myofibril#GO:0030016;supramolecular fiber#GO:0099512;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle#GO:0043229;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;contractile muscle fiber#GO:0043292;nuclear protein-containing complex#GO:0140513;sarcomere#GO:0030017;RNA polymerase II, core complex#GO:0005665;intracellular membrane-bounded organelle#GO:0043231;nuclear DNA-directed RNA polymerase complex#GO:0055029;RNA polymerase II, holoenzyme#GO:0016591;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;catalytic complex#GO:1902494;membrane-enclosed lumen#GO:0031974;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;membraneless organelle#GO:0043228;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;I band#GO:0031674 DNA-directed RNA polymerase#PC00019;RNA metabolism protein#PC00031 HUMAN|HGNC=25096|UniProtKB=Q9BU23 Q9BU23 LMF2 PTHR14463:SF5 LIPASE MATURATION FACTOR LIPASE MATURATION FACTOR 2 primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020 HUMAN|HGNC=35459|UniProtKB=A6NKD9 A6NKD9 CCDC85C PTHR13546:SF14 RE60986P COILED-COIL DOMAIN-CONTAINING PROTEIN 85C apical junction complex#GO:0043296;cell-cell junction#GO:0005911;anchoring junction#GO:0070161;cell junction#GO:0030054;cellular anatomical structure#GO:0110165 HUMAN|HGNC=3218|UniProtKB=Q12805 Q12805 EFEMP1 PTHR24039:SF33 FIBRILLIN-RELATED EGF-CONTAINING FIBULIN-LIKE EXTRACELLULAR MATRIX PROTEIN 1 extracellular matrix structural protein#PC00103 HUMAN|HGNC=17078|UniProtKB=O75122 O75122 CLASP2 PTHR21567:SF30 CLASP CLIP-ASSOCIATING PROTEIN 2 binding#GO:0005488;microtubule binding#GO:0008017;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515 cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;chromosome segregation#GO:0007059;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;spindle assembly#GO:0051225;establishment of mitotic spindle localization#GO:0040001;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;spindle localization#GO:0051653;cellular localization#GO:0051641;nuclear division#GO:0000280;establishment of organelle localization#GO:0051656;mitotic spindle organization#GO:0007052;nuclear chromosome segregation#GO:0098813;sister chromatid segregation#GO:0000819;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;mitotic nuclear division#GO:0140014;cell cycle process#GO:0022402;establishment of localization#GO:0051234;spindle organization#GO:0007051;chromosome organization#GO:0051276;mitotic cell cycle process#GO:1903047;mitotic sister chromatid segregation#GO:0000070;mitotic spindle assembly#GO:0090307;establishment of spindle localization#GO:0051293;microtubule cytoskeleton organization#GO:0000226;organelle fission#GO:0048285;localization#GO:0051179;organelle localization#GO:0051640;organelle assembly#GO:0070925;mitotic cell cycle#GO:0000278;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cell cycle#GO:0007049 polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;chromosome, centromeric region#GO:0000775;condensed chromosome#GO:0000793;cytoskeleton#GO:0005856;spindle#GO:0005819;microtubule organizing center#GO:0005815;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cell periphery#GO:0071944;condensed chromosome, centromeric region#GO:0000779;microtubule cytoskeleton#GO:0015630;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;spindle microtubule#GO:0005876;microtubule#GO:0005874;intracellular organelle#GO:0043229;mitotic spindle#GO:0072686;cellular anatomical structure#GO:0110165;organelle#GO:0043226;kinetochore#GO:0000776;cell cortex#GO:0005938;cytoplasmic microtubule#GO:0005881;chromosome#GO:0005694;basal part of cell#GO:0045178 microtubule or microtubule-binding cytoskeletal protein#PC00157;non-motor microtubule binding protein#PC00166;cytoskeletal protein#PC00085 HUMAN|HGNC=20952|UniProtKB=Q9P0S9 Q9P0S9 TMEM14C PTHR12668:SF4 TRANSMEMBRANE PROTEIN 14, 15 TRANSMEMBRANE PROTEIN 14C-RELATED tetrapyrrole metabolic process#GO:0033013;metabolic process#GO:0008152;pigment biosynthetic process#GO:0046148;porphyrin-containing compound metabolic process#GO:0006778;porphyrin-containing compound biosynthetic process#GO:0006779;heme biosynthetic process#GO:0006783;pigment metabolic process#GO:0042440;cellular process#GO:0009987;tetrapyrrole biosynthetic process#GO:0033014;biosynthetic process#GO:0009058;heme metabolic process#GO:0042168 membrane#GO:0016020;organelle envelope#GO:0031967;mitochondrial envelope#GO:0005740;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=16470|UniProtKB=Q86VQ3 Q86VQ3 TXNDC2 PTHR10438:SF107 THIOREDOXIN THIOREDOXIN DOMAIN-CONTAINING PROTEIN 2 catalytic activity#GO:0003824;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;disulfide oxidoreductase activity#GO:0015036;protein-disulfide reductase activity#GO:0015035;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491 flagellated sperm motility#GO:0030317;cilium or flagellum-dependent cell motility#GO:0001539;cilium movement#GO:0003341;cilium-dependent cell motility#GO:0060285;cell redox homeostasis#GO:0045454;cellular homeostasis#GO:0019725;microtubule-based process#GO:0007017;cilium movement involved in cell motility#GO:0060294;sperm motility#GO:0097722;cellular process#GO:0009987;cell motility#GO:0048870;microtubule-based movement#GO:0007018;homeostatic process#GO:0042592;reproductive process#GO:0022414 cell projection#GO:0042995;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;organelle#GO:0043226;motile cilium#GO:0031514;sperm flagellum#GO:0036126;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;cytosol#GO:0005829;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cilium#GO:0005929;9+2 motile cilium#GO:0097729;intracellular organelle#GO:0043229 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 Oxidative stress response#P00046>TRX#P01122 HUMAN|HGNC=25173|UniProtKB=Q96CS4 Q96CS4 ZNF689 PTHR24377:SF695 IP01015P-RELATED ZINC FINGER PROTEIN 689 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=10942|UniProtKB=P43007 P43007 SLC1A4 PTHR11958:SF20 SODIUM/DICARBOXYLATE SYMPORTER-RELATED NEUTRAL AMINO ACID TRANSPORTER A symporter activity#GO:0015293;sodium:dicarboxylate symporter activity#GO:0017153;monoatomic cation transmembrane transporter activity#GO:0008324;amino acid transmembrane transporter activity#GO:0015171;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;C4-dicarboxylate transmembrane transporter activity#GO:0015556;carboxylic acid transmembrane transporter activity#GO:0046943;solute:sodium symporter activity#GO:0015370;amino acid:sodium symporter activity#GO:0005283;transmembrane transporter activity#GO:0022857;neutral L-amino acid transmembrane transporter activity#GO:0015175;dicarboxylic acid transmembrane transporter activity#GO:0005310;L-glutamate transmembrane transporter activity#GO:0005313;solute:monoatomic cation symporter activity#GO:0015294;active transmembrane transporter activity#GO:0022804;acidic amino acid transmembrane transporter activity#GO:0015172;L-amino acid transmembrane transporter activity#GO:0015179;sodium ion transmembrane transporter activity#GO:0015081 L-alpha-amino acid transmembrane transport#GO:1902475;carboxylic acid transmembrane transport#GO:1905039;L-glutamate import#GO:0051938;amino acid transmembrane transport#GO:0003333;neutral amino acid transport#GO:0015804;transmembrane transport#GO:0055085;localization#GO:0051179;nitrogen compound transport#GO:0071705;L-amino acid transport#GO:0015807;cellular process#GO:0009987;dicarboxylic acid transport#GO:0006835;L-glutamate transmembrane transport#GO:0015813;transport#GO:0006810;carboxylic acid transport#GO:0046942;acidic amino acid transport#GO:0015800;organic acid transport#GO:0015849;amino acid transport#GO:0006865;establishment of localization#GO:0051234 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 primary active transporter#PC00068 HUMAN|HGNC=16285|UniProtKB=Q9UPQ4 Q9UPQ4 TRIM35 PTHR24103:SF665 E3 UBIQUITIN-PROTEIN LIGASE TRIM E3 UBIQUITIN-PROTEIN LIGASE TRIM35 catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842 regulation of programmed cell death#GO:0043067;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;positive regulation of programmed cell death#GO:0043068;response to stimulus#GO:0050896;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;immune system process#GO:0002376;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;positive regulation of biological process#GO:0048518;defense response to symbiont#GO:0140546;positive regulation of cellular process#GO:0048522;immune response#GO:0006955;defense response to other organism#GO:0098542;response to other organism#GO:0051707;biological regulation#GO:0065007;regulation of apoptotic process#GO:0042981;innate immune response#GO:0045087;positive regulation of apoptotic process#GO:0043065;defense response#GO:0006952;response to external stimulus#GO:0009605 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=6401|UniProtKB=Q92973 Q92973 TNPO1 PTHR10527:SF21 IMPORTIN BETA TRANSPORTIN-1 molecular carrier activity#GO:0140104;nucleocytoplasmic carrier activity#GO:0140142 establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;transport#GO:0006810;intracellular protein transport#GO:0006886;protein localization to nucleus#GO:0034504;import into nucleus#GO:0051170;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular localization#GO:0051641;localization#GO:0051179;protein import into nucleus#GO:0006606;protein transport#GO:0015031;nuclear transport#GO:0051169;nucleocytoplasmic transport#GO:0006913;protein localization to organelle#GO:0033365 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 transporter#PC00227 HUMAN|HGNC=167|UniProtKB=P61163 P61163 ACTR1A PTHR11937:SF370 ACTIN ALPHA-CENTRACTIN cytoskeletal adaptor activity#GO:0008093;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;structural constituent of cytoskeleton#GO:0005200;protein-membrane adaptor activity#GO:0043495;structural molecule activity#GO:0005198 microtubule-based movement#GO:0007018;establishment of organelle localization#GO:0051656;nuclear migration#GO:0007097;localization#GO:0051179;cellular localization#GO:0051641;organelle localization#GO:0051640;microtubule-based transport#GO:0099111;cytoskeleton-dependent intracellular transport#GO:0030705;organelle transport along microtubule#GO:0072384;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;transport along microtubule#GO:0010970;establishment of localization#GO:0051234;microtubule-based process#GO:0007017;intracellular transport#GO:0046907;transport#GO:0006810 intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;microtubule cytoskeleton#GO:0015630;actin cytoskeleton#GO:0015629;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 actin and actin related protein#PC00039 Nicotinic acetylcholine receptor signaling pathway#P00044>Actin#P01090 HUMAN|HGNC=20982|UniProtKB=Q9NRG4 Q9NRG4 SMYD2 PTHR12197:SF193 HISTONE-LYSINE N-METHYLTRANSFERASE SMYD N-LYSINE METHYLTRANSFERASE SMYD2 histone H3 methyltransferase activity#GO:0140938;histone modifying activity#GO:0140993;lysine N-methyltransferase activity#GO:0016278;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;N-methyltransferase activity#GO:0008170;protein-lysine N-methyltransferase activity#GO:0016279;histone methyltransferase activity#GO:0042054;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein methyltransferase activity#GO:0008276;histone H3K36 methyltransferase activity#GO:0046975 anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;animal gross anatomical part developmental process#GO:0160108;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;circulatory system development#GO:0072359;negative regulation of metabolic process#GO:0009892;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;multicellular organism development#GO:0007275;animal organ development#GO:0048513;negative regulation of macromolecule biosynthetic process#GO:0010558;heart development#GO:0007507 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 histone modifying enzyme#PC00261 HUMAN|HGNC=1249|UniProtKB=Q9ULW0 Q9ULW0 TPX2 PTHR14326:SF67 TARGETING PROTEIN FOR XKLP2 TARGETING PROTEIN FOR XKLP2 enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;kinase activator activity#GO:0019209;protein kinase regulator activity#GO:0019887;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047;protein serine/threonine kinase activator activity#GO:0043539;protein kinase activator activity#GO:0030295 chromosome segregation#GO:0007059;chromosome organization#GO:0051276;microtubule-based process#GO:0007017;mitotic cell cycle process#GO:1903047;cellular component organization or biogenesis#GO:0071840;spindle organization#GO:0007051;mitotic spindle assembly#GO:0090307;cellular process#GO:0009987;spindle assembly#GO:0051225;cellular component biogenesis#GO:0044085;mitotic sister chromatid segregation#GO:0000070;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;nuclear division#GO:0000280;organelle assembly#GO:0070925;organelle fission#GO:0048285;microtubule cytoskeleton organization#GO:0000226;mitotic nuclear division#GO:0140014;cell cycle process#GO:0022402;microtubule cytoskeleton organization involved in mitosis#GO:1902850;nuclear chromosome segregation#GO:0098813;cellular component organization#GO:0016043;sister chromatid segregation#GO:0000819;membraneless organelle assembly#GO:0140694;cell cycle#GO:0007049;mitotic spindle organization#GO:0007052;mitotic cell cycle#GO:0000278 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;spindle#GO:0005819;intracellular membraneless organelle#GO:0043232;mitotic spindle#GO:0072686;cellular anatomical structure#GO:0110165;organelle#GO:0043226;spindle pole#GO:0000922;microtubule cytoskeleton#GO:0015630 microtubule or microtubule-binding cytoskeletal protein#PC00157;non-motor microtubule binding protein#PC00166 HUMAN|HGNC=4408|UniProtKB=P63218 P63218 GNG5 PTHR13809:SF5 GUANINE NUCLEOTIDE-BINDING PROTEIN GAMMA SUBUNIT GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)_G(S)_G(O) SUBUNIT GAMMA-5-RELATED GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity#GO:0016787;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817;molecular function regulator activity#GO:0098772;ribonucleoside triphosphate phosphatase activity#GO:0017111 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 extrinsic component of plasma membrane#GO:0019897;side of membrane#GO:0098552;extrinsic component of membrane#GO:0019898;cytoplasmic side of membrane#GO:0098562;extrinsic component of cytoplasmic side of plasma membrane#GO:0031234;catalytic complex#GO:1902494;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane#GO:0016020;cytoplasmic side of plasma membrane#GO:0009898;membrane protein complex#GO:0098796 heterotrimeric G-protein#PC00117 Beta2 adrenergic receptor signaling pathway#P04378>G-Protein#P04443;Histamine H2 receptor mediated signaling pathway#P04386>G-Protein#P04490;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Ggamma#P00721;GABA-B receptor II signaling#P05731>Ggamma#P05754;5HT1 type receptor mediated signaling pathway#P04373>G-protein#P04408;Histamine H1 receptor mediated signaling pathway#P04385>G-Protein#P04488;Opioid proenkephalin pathway#P05915>G-protein#P05994;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Ggamma#P00726;Metabotropic glutamate receptor group II pathway#P00040>G-protein#P01047;Beta1 adrenergic receptor signaling pathway#P04377>G-Protein#P04436;Opioid prodynorphin pathway#P05916>G-protein#P06002;Beta3 adrenergic receptor signaling pathway#P04379>G-Protein#P04448;Endogenous cannabinoid signaling#P05730>Ggamma#P05744;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GIRK#P00743;Wnt signaling pathway#P00057>Ggamma#P01465;Opioid proopiomelanocortin pathway#P05917>G-protein#P06012;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>G-Protein#P01073;Metabotropic glutamate receptor group III pathway#P00039>G-Protein#P01045;5HT4 type receptor mediated signaling pathway#P04376>G-protein#P04430;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>G-Protein#P01085;Cortocotropin releasing factor receptor signaling pathway#P04380>G-Protein#P04458;Oxytocin receptor mediated signaling pathway#P04391>G-Protein#P04534;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Ggamma#P00751;5HT2 type receptor mediated signaling pathway#P04374>G-protein#P04416;Thyrotropin-releasing hormone receptor signaling pathway#P04394>G-Protein#P04584;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Gbetagamma#P00836;Enkephalin release#P05913>G-Protein (s)#P05977;Enkephalin release#P05913>G-Protein (i)#P05974 HUMAN|HGNC=4582|UniProtKB=Q16099 Q16099 GRIK4 PTHR18966:SF171 IONOTROPIC GLUTAMATE RECEPTOR GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 4 sodium ion transmembrane transporter activity#GO:0015081;monoatomic cation channel activity#GO:0005261;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;dicarboxylic acid transmembrane transporter activity#GO:0005310;ligand-gated monoatomic cation channel activity#GO:0099094;sodium channel activity#GO:0005272;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;glutamate receptor activity#GO:0008066;ligand-gated channel activity#GO:0022834;channel activity#GO:0015267;molecular transducer activity#GO:0060089;potassium ion transmembrane transporter activity#GO:0015079;potassium channel activity#GO:0005267;ligand-gated monoatomic ion channel activity#GO:0015276;carboxylic acid transmembrane transporter activity#GO:0046943;signaling receptor activity#GO:0038023;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;transporter activity#GO:0005215;neurotransmitter receptor activity#GO:0030594;amino acid transmembrane transporter activity#GO:0015171;monoatomic cation transmembrane transporter activity#GO:0008324;transmembrane signaling receptor activity#GO:0004888;gated channel activity#GO:0022836 biological regulation#GO:0065007;cell-cell signaling#GO:0007267;synaptic transmission, glutamatergic#GO:0035249;regulation of trans-synaptic signaling#GO:0099177;cellular process#GO:0009987;synaptic signaling#GO:0099536;modulation of chemical synaptic transmission#GO:0050804;signaling#GO:0023052;regulation of cell communication#GO:0010646;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;cell communication#GO:0007154;regulation of signaling#GO:0023051;trans-synaptic signaling#GO:0099537 synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;asymmetric synapse#GO:0032279;postsynapse#GO:0098794;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;transmembrane transporter complex#GO:1902495;postsynaptic density membrane#GO:0098839;sodium channel complex#GO:0034706;postsynaptic specialization membrane#GO:0099634;postsynaptic membrane#GO:0045211;postsynaptic density#GO:0014069;neuron to neuron synapse#GO:0098984;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane region#GO:0098590;postsynaptic specialization#GO:0099572;presynaptic membrane#GO:0042734;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;presynapse#GO:0098793;transporter complex#GO:1990351;cell junction#GO:0030054;synaptic membrane#GO:0097060;signaling receptor complex#GO:0043235;cation channel complex#GO:0034703 transmembrane signal receptor#PC00197 Huntington disease#P00029>Kainate receptor#P00796;Metabotropic glutamate receptor group III pathway#P00039>A/K#P01046;Ionotropic glutamate receptor pathway#P00037>A/K#P01025;Ionotropic glutamate receptor pathway#P00037>KA4#P01001;Ionotropic glutamate receptor pathway#P00037>KA#P01026 HUMAN|HGNC=4215|UniProtKB=P55107 P55107 GDF10 PTHR11848:SF145 TGF-BETA FAMILY GROWTH_DIFFERENTIATION FACTOR 10 signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;cytokine activity#GO:0005125;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772 biological regulation#GO:0065007;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165;cellular process#GO:0009987;positive regulation of developmental process#GO:0051094;regulation of cell differentiation#GO:0045595;cell surface receptor signaling pathway#GO:0007166;positive regulation of cell differentiation#GO:0045597;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;regulation of developmental process#GO:0050793;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 growth factor#PC00112 TGF-beta signaling pathway#P00052>TGFbeta#P01286 HUMAN|HGNC=8792|UniProtKB=Q9NP56 Q9NP56 PDE7B PTHR11347:SF72 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 3',5'-CYCLIC-AMP PHOSPHODIESTERASE 7B hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;cyclic-nucleotide phosphodiesterase activity#GO:0004112;hydrolase activity#GO:0016787;phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578 regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of signal transduction#GO:0009968;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;negative regulation of response to stimulus#GO:0048585;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;negative regulation of cellular process#GO:0048523;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532 phosphodiesterase#PC00185;hydrolase#PC00121 HUMAN|HGNC=8140|UniProtKB=O60313 O60313 OPA1 PTHR11566:SF67 DYNAMIN DYNAMIN-LIKE GTPASE OPA1, MITOCHONDRIAL ribonucleoside triphosphate phosphatase activity#GO:0017111;cytoskeletal protein binding#GO:0008092;hydrolase activity, acting on acid anhydrides#GO:0016817;tubulin binding#GO:0015631;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;protein binding#GO:0005515;hydrolase activity#GO:0016787;microtubule binding#GO:0008017;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488 cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;mitochondrial fusion#GO:0008053;mitochondrion organization#GO:0007005;organelle fusion#GO:0048284;cellular component organization or biogenesis#GO:0071840 polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;organelle membrane#GO:0031090;mitochondrial intermembrane space#GO:0005758;cytoskeleton#GO:0005856;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630;membrane-enclosed lumen#GO:0031974;membrane#GO:0016020;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;microtubule#GO:0005874;supramolecular fiber#GO:0099512;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;organelle lumen#GO:0043233;mitochondrion#GO:0005739 membrane traffic protein#PC00150 HUMAN|HGNC=18311|UniProtKB=Q9BS26 Q9BS26 ERP44 PTHR46295:SF1 ENDOPLASMIC RETICULUM RESIDENT PROTEIN 44 ENDOPLASMIC RETICULUM RESIDENT PROTEIN 44 intramolecular oxidoreductase activity#GO:0016860;catalytic activity, acting on a protein#GO:0140096;isomerase activity#GO:0016853;catalytic activity#GO:0003824;protein disulfide isomerase activity#GO:0003756 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;protein folding#GO:0006457;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 organelle membrane#GO:0031090;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;cytoplasm#GO:0005737;endomembrane system#GO:0012505;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793 HUMAN|HGNC=10634|UniProtKB=P80098 P80098 CCL7 PTHR12015:SF161 SMALL INDUCIBLE CYTOKINE A C-C MOTIF CHEMOKINE 7 molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;chemokine activity#GO:0008009;G protein-coupled receptor binding#GO:0001664;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;molecular function activator activity#GO:0140677;protein binding#GO:0005515;chemokine receptor binding#GO:0042379;cytokine activity#GO:0005125;signaling receptor binding#GO:0005102;cytokine receptor binding#GO:0005126;binding#GO:0005488 cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;immune system process#GO:0002376;response to peptide#GO:1901652;positive regulation of cell motility#GO:2000147;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;granulocyte chemotaxis#GO:0071621;response to stimulus#GO:0050896;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;humoral immune response#GO:0006959;antimicrobial humoral response#GO:0019730;cell surface receptor signaling pathway#GO:0007166;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;response to chemokine#GO:1990868;cellular process#GO:0009987;signal transduction#GO:0007165;defense response to symbiont#GO:0140546;positive regulation of biological process#GO:0048518;granulocyte migration#GO:0097530;defense response to other organism#GO:0098542;response to chemical#GO:0042221;taxis#GO:0042330;response to cytokine#GO:0034097;cytokine-mediated signaling pathway#GO:0019221;chemotaxis#GO:0006935;inflammatory response#GO:0006954;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;regulation of cell motility#GO:2000145;chemokine-mediated signaling pathway#GO:0070098;cell communication#GO:0007154;cell chemotaxis#GO:0060326;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;cell motility#GO:0048870;cellular response to chemokine#GO:1990869;locomotion#GO:0040011;response to external biotic stimulus#GO:0043207;leukocyte migration#GO:0050900;regulation of cell migration#GO:0030334;defense response#GO:0006952;leukocyte chemotaxis#GO:0030595;response to external stimulus#GO:0009605;myeloid leukocyte migration#GO:0097529;positive regulation of locomotion#GO:0040017;positive regulation of cell migration#GO:0030335;immune response#GO:0006955;positive regulation of cellular process#GO:0048522;cell migration#GO:0016477;regulation of locomotion#GO:0040012;response to other organism#GO:0051707;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 cytokine#PC00083 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CHK#P00856 HUMAN|HGNC=14900|UniProtKB=Q9GZX6 Q9GZX6 IL22 PTHR48488:SF1 INTERLEUKIN-22 INTERLEUKIN-22 molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677;cytokine activity#GO:0005125;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545 regulation of response to external stimulus#GO:0032101;negative regulation of response to stimulus#GO:0048585;negative regulation of defense response#GO:0031348;negative regulation of inflammatory response#GO:0050728;negative regulation of response to external stimulus#GO:0032102;biological regulation#GO:0065007;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of response to stress#GO:0080134;regulation of inflammatory response#GO:0050727;regulation of response to stimulus#GO:0048583;regulation of defense response#GO:0031347 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=16259|UniProtKB=Q8IZL2 Q8IZL2 MAML2 PTHR15692:SF9 MASTERMIND-LIKE MASTERMIND-LIKE PROTEIN 2 transcription coactivator activity#GO:0003713;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 cellular response to stimulus#GO:0051716;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;cell communication#GO:0007154;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of cellular process#GO:0048522;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;Notch signaling pathway#GO:0007219;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;signaling#GO:0023052;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of transcription by RNA polymerase II#GO:0045944;cell surface receptor signaling pathway#GO:0007166 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HUMAN|HGNC=8860|UniProtKB=O00628 O00628 PEX7 PTHR46027:SF1 PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR signal sequence receptor activity#GO:0005048 cellular component organization or biogenesis#GO:0071840;establishment of protein localization to organelle#GO:0072594;intracellular protein transmembrane transport#GO:0065002;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;protein transmembrane import into intracellular organelle#GO:0044743;protein transmembrane transport#GO:0071806;intracellular protein transport#GO:0006886;transport#GO:0006810;macromolecule localization#GO:0033036;organelle organization#GO:0006996;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;localization#GO:0051179;cellular localization#GO:0051641;transmembrane transport#GO:0055085;protein transport#GO:0015031;peroxisomal transport#GO:0043574;peroxisome organization#GO:0007031;protein localization to organelle#GO:0033365;protein import into peroxisome matrix#GO:0016558;cellular component organization#GO:0016043 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;peroxisomal matrix#GO:0005782;cytosol#GO:0005829;peroxisome#GO:0005777;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;microbody#GO:0042579;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=13502|UniProtKB=Q9HBT7 Q9HBT7 ZNF287 PTHR23226:SF194 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER PROTEIN 287 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=32266|UniProtKB=P0DV75 P0DV75 FAM90A18 PTHR16035:SF14 PROTEIN FAM90A1 PROTEIN FAM90A10-RELATED HUMAN|HGNC=29205|UniProtKB=Q969X5 Q969X5 ERGIC1 PTHR10984:SF36 ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 1 vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;localization#GO:0051179;Golgi vesicle transport#GO:0048193;cellular process#GO:0009987;transport#GO:0006810;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890 organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;cytoplasm#GO:0005737;endomembrane system#GO:0012505;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;coated vesicle#GO:0030135;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;COPII-coated ER to Golgi transport vesicle#GO:0030134;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;vesicle#GO:0031982;intracellular vesicle#GO:0097708 HUMAN|HGNC=10451|UniProtKB=P23921 P23921 RRM1 PTHR11573:SF6 RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT carbohydrate derivative binding#GO:0097367;catalytic activity#GO:0003824;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;ribonucleotide binding#GO:0032553;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;oxidoreductase activity#GO:0016491;nucleotide binding#GO:0000166;nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167;binding#GO:0005488;anion binding#GO:0043168;ATP binding#GO:0005524;small molecule binding#GO:0036094 cellular process#GO:0009987;metabolic process#GO:0008152;biosynthetic process#GO:0009058 catalytic complex#GO:1902494;cytosol#GO:0005829;oxidoreductase complex#GO:1990204;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 oxidoreductase#PC00176;reductase#PC00198 De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>CDP Reductase#P02915;De novo purine biosynthesis#P02738>ADP reductase#P02902;De novo purine biosynthesis#P02738>GDP reductase#P02909;De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>UDP reductase#P02921 HUMAN|HGNC=29873|UniProtKB=Q8N5F7 Q8N5F7 NKAP PTHR13087:SF2 NF-KAPPA B ACTIVATING PROTEIN NF-KAPPA-B-ACTIVATING PROTEIN binding#GO:0005488;chromatin binding#GO:0003682 negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of metabolic process#GO:0009892;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=26278|UniProtKB=Q96AB3 Q96AB3 ISOC2 PTHR14119:SF19 HYDROLASE ISOCHORISMATASE DOMAIN-CONTAINING PROTEIN 2 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 hydrolase#PC00121;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=13187|UniProtKB=P60852 P60852 ZP1 PTHR23343:SF41 ZONA PELLUCIDA SPERM-BINDING PROTEIN ZONA PELLUCIDA SPERM-BINDING PROTEIN 1 enzyme binding#GO:0019899;extracellular matrix structural constituent#GO:0005201;binding#GO:0005488;structural molecule activity#GO:0005198;protein binding#GO:0005515 single fertilization#GO:0007338;negative regulation of biological process#GO:0048519;cellular process#GO:0009987;regulation of biological process#GO:0050789;multicellular organismal process#GO:0032501;regulation of reproductive process#GO:2000241;fertilization#GO:0009566;reproductive process#GO:0022414;biological regulation#GO:0065007;sperm-egg recognition#GO:0035036;cell recognition#GO:0008037;cell activation#GO:0001775;sexual reproduction#GO:0019953;binding of sperm to zona pellucida#GO:0007339;cell-cell recognition#GO:0009988 external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=32159|UniProtKB=Q9BT17 Q9BT17 MTG1 PTHR45782:SF4 MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1 MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1 hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787 mitochondrial ribosome assembly#GO:0061668;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;protein-RNA complex organization#GO:0071826;cellular component assembly#GO:0022607;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;ribosomal large subunit assembly#GO:0000027;protein-RNA complex assembly#GO:0022618;organelle assembly#GO:0070925;ribosomal large subunit biogenesis#GO:0042273;ribosome assembly#GO:0042255;ribosome biogenesis#GO:0042254;ribonucleoprotein complex biogenesis#GO:0022613;protein-containing complex assembly#GO:0065003;membraneless organelle assembly#GO:0140694;mitochondrial large ribosomal subunit assembly#GO:1902775;cellular component organization#GO:0016043 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739 HUMAN|HGNC=20323|UniProtKB=Q9H3U7 Q9H3U7 SMOC2 PTHR12352:SF21 SECRETED MODULAR CALCIUM-BINDING PROTEIN SPARC-RELATED MODULAR CALCIUM-BINDING PROTEIN 2 heparin binding#GO:0008201;carbohydrate derivative binding#GO:0097367;glycosaminoglycan binding#GO:0005539;binding#GO:0005488;extracellular matrix binding#GO:0050840 external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;extracellular structure organization#GO:0043062;cellular component organization#GO:0016043 cellular anatomical structure#GO:0110165;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576;basement membrane#GO:0005604 calmodulin-related#PC00061 HUMAN|HGNC=470|UniProtKB=Q01432 Q01432 AMPD3 PTHR11359:SF2 AMP DEAMINASE AMP DEAMINASE 3 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;deaminase activity#GO:0019239;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity#GO:0016787;catalytic activity#GO:0003824 metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing compound biosynthetic process#GO:0034654;purine nucleoside monophosphate metabolic process#GO:0009126;nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative biosynthetic process#GO:1901137;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;ribose phosphate biosynthetic process#GO:0046390;purine nucleotide biosynthetic process#GO:0006164;nucleoside monophosphate biosynthetic process#GO:0009124;purine-containing compound biosynthetic process#GO:0072522;ribonucleotide metabolic process#GO:0009259;nucleotide biosynthetic process#GO:0009165;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;phosphorus metabolic process#GO:0006793;purine ribonucleoside monophosphate metabolic process#GO:0009167;small molecule metabolic process#GO:0044281;nucleoside phosphate biosynthetic process#GO:1901293;carbohydrate derivative metabolic process#GO:1901135;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;organophosphate biosynthetic process#GO:0090407;IMP biosynthetic process#GO:0006188;primary metabolic process#GO:0044238;nucleoside monophosphate metabolic process#GO:0009123;nucleoside phosphate metabolic process#GO:0006753;IMP metabolic process#GO:0046040 deaminase#PC00088 Purine metabolism#P02769>5'-AMP Deaminase#P03117 HUMAN|HGNC=2411|UniProtKB=P07320 P07320 CRYGD PTHR11818:SF145 BETA/GAMMA CRYSTALLIN GAMMA-CRYSTALLIN D structural molecule activity#GO:0005198 animal organ development#GO:0048513;multicellular organism development#GO:0007275;system process#GO:0003008;sensory organ development#GO:0007423;developmental process#GO:0032502;lens development in camera-type eye#GO:0002088;multicellular organismal process#GO:0032501;sensory system development#GO:0048880;anatomical structure development#GO:0048856;eye development#GO:0001654;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;camera-type eye development#GO:0043010;nervous system process#GO:0050877;sensory perception#GO:0007600;visual perception#GO:0007601;visual system development#GO:0150063;sensory perception of light stimulus#GO:0050953 structural protein#PC00211 HUMAN|HGNC=15516|UniProtKB=Q86Y38 Q86Y38 XYLT1 PTHR46025:SF2 XYLOSYLTRANSFERASE OXT XYLOSYLTRANSFERASE 1 catalytic activity#GO:0003824;transferase activity#GO:0016740;UDP-xylosyltransferase activity#GO:0035252;glycosyltransferase activity#GO:0016757;catalytic activity, acting on a protein#GO:0140096;UDP-glycosyltransferase activity#GO:0008194;pentosyltransferase activity#GO:0016763;xylosyltransferase activity#GO:0042285 primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;glycoprotein biosynthetic process#GO:0009101;protein O-linked glycosylation#GO:0006493;macromolecule biosynthetic process#GO:0009059;chondroitin sulfate proteoglycan metabolic process#GO:0050654;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;chondroitin sulfate proteoglycan biosynthetic process#GO:0050650;biosynthetic process#GO:0009058;proteoglycan biosynthetic process#GO:0030166;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;proteoglycan metabolic process#GO:0006029 transferase#PC00220 HUMAN|HGNC=37271|UniProtKB=A6NMK8 A6NMK8 INSYN2B PTHR28682:SF2 INHIBITORY SYNAPTIC FACTOR 2A-RELATED PROTEIN INSYN2B HUMAN|HGNC=35475|UniProtKB=A8MYZ0 A8MYZ0 MINDY4B PTHR12473:SF18 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MINDY-4-RELATED INACTIVE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MINDY-4B deubiquitinase activity#GO:0101005;catalytic activity#GO:0003824;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096 HUMAN|HGNC=33340|UniProtKB=Q1W6H9 Q1W6H9 FAM110C PTHR14758:SF5 AGAP005440-PA PROTEIN FAM110C protein binding#GO:0005515;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;binding#GO:0005488 positive regulation of locomotion#GO:0040017;regulation of cell projection assembly#GO:0060491;regulation of cell motility#GO:2000145;regulation of cell migration#GO:0030334;regulation of cell projection organization#GO:0031344;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;regulation of cellular component biogenesis#GO:0044087;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;positive regulation of cell migration#GO:0030335;positive regulation of cell motility#GO:2000147 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cell cortex#GO:0005938;cell periphery#GO:0071944 HUMAN|HGNC=25000|UniProtKB=Q7Z3V5 Q7Z3V5 ZNF571 PTHR24377:SF141 IP01015P-RELATED ZINC FINGER PROTEIN 571 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=6842|UniProtKB=P36507 P36507 MAP2K2 PTHR48013:SF8 DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2 protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;intracellular signaling cassette#GO:0141124;signaling#GO:0023052;biological regulation#GO:0065007;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;MAPK cascade#GO:0000165;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 non-receptor serine/threonine protein kinase#PC00167 Gonadotropin-releasing hormone receptor pathway#P06664>MEK1/2#P06739;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>MEK#P00891;VEGF signaling pathway#P00056>MEK#P01402;FGF signaling pathway#P00021>MEK1-2#P00642;Ras Pathway#P04393>MEK#P04557;Toll receptor signaling pathway#P00054>MKK2#P01368;Gonadotropin-releasing hormone receptor pathway#P06664>MAP2K1/2#P06794;Endothelin signaling pathway#P00019>MEK#P00572;B cell activation#P00010>MEK#P00383;Integrin signalling pathway#P00034>MEK#P00925;CCKR signaling map#P06959>MAP2K2#P07121;EGF receptor signaling pathway#P00018>MEK1-2#P00559;T cell activation#P00053>MEK#P01312;Angiotensin II-stimulated signaling through G proteins and beta-arrestin#P05911>MEK#P05926;Angiogenesis#P00005>MEK#P00225;PDGF signaling pathway#P00047>MEK#P01162 HUMAN|HGNC=8624|UniProtKB=Q6ZW49 Q6ZW49 PAXIP1 PTHR23196:SF48 PAX TRANSCRIPTION ACTIVATION DOMAIN INTERACTING PROTEIN PAX-INTERACTING PROTEIN 1 DNA damage response#GO:0006974;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;response to stress#GO:0006950;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;cellular response to stress#GO:0033554;regulation of RNA metabolic process#GO:0051252;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of DNA-templated transcription initiation#GO:2000142;cellular response to stimulus#GO:0051716;positive regulation of RNA metabolic process#GO:0051254;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 organelle#GO:0043226;methyltransferase complex#GO:0034708;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234;histone methyltransferase complex#GO:0035097 HUMAN|HGNC=19391|UniProtKB=O14543 O14543 SOCS3 PTHR10155:SF11 PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT SUPPRESSOR OF CYTOKINE SIGNALING 3 binding#GO:0005488;signaling receptor binding#GO:0005102;cytokine receptor binding#GO:0005126;protein binding#GO:0005515 regulation of receptor signaling pathway via JAK-STAT#GO:0046425;regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of signal transduction#GO:0009968;response to cytokine#GO:0034097;response to chemical#GO:0042221;negative regulation of response to stimulus#GO:0048585;signal transduction#GO:0007165;cellular process#GO:0009987;negative regulation of cell communication#GO:0010648;response to peptide#GO:1901652;cell communication#GO:0007154;regulation of signaling#GO:0023051;cytokine-mediated signaling pathway#GO:0019221;negative regulation of signaling#GO:0023057;signaling#GO:0023052;regulation of receptor signaling pathway via STAT#GO:1904892;regulation of cell communication#GO:0010646;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;cellular response to stimulus#GO:0051716;negative regulation of biological process#GO:0048519 kinase modulator#PC00140 Interferon-gamma signaling pathway#P00035>SOCS#P00956 HUMAN|HGNC=1555|UniProtKB=P45973 P45973 CBX5 PTHR22812:SF85 CHROMOBOX PROTEIN CHROMOBOX PROTEIN HOMOLOG 5 chromatin binding#GO:0003682;binding#GO:0005488 epigenetic regulation of gene expression#GO:0040029;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;cellular component assembly#GO:0022607;heterochromatin organization#GO:0070828;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;chromatin organization#GO:0006325;negative regulation of cellular process#GO:0048523;regulation of biosynthetic process#GO:0009889;negative regulation of gene expression, epigenetic#GO:0045814;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;heterochromatin formation#GO:0031507;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694;chromatin#GO:0000785;heterochromatin#GO:0000792;membraneless organelle#GO:0043228;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;chromosome, centromeric region#GO:0000775;intracellular organelle#GO:0043229 HUMAN|HGNC=4171|UniProtKB=P23769 P23769 GATA2 PTHR10071:SF149 TRANSCRIPTION FACTOR GATA FAMILY MEMBER ENDOTHELIAL TRANSCRIPTION FACTOR GATA-2 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of anatomical structure morphogenesis#GO:0022603;positive regulation of transcription by RNA polymerase II#GO:0045944;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;positive regulation of macromolecule metabolic process#GO:0010604;regulation of multicellular organismal process#GO:0051239;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;negative regulation of DNA-templated transcription#GO:0045892;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;cell fate commitment#GO:0045165;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;positive regulation of angiogenesis#GO:0045766;negative regulation of biological process#GO:0048519;regulation of multicellular organismal development#GO:2000026;positive regulation of multicellular organismal process#GO:0051240;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;regulation of vasculature development#GO:1901342;negative regulation of cellular process#GO:0048523;positive regulation of developmental process#GO:0051094;developmental process#GO:0032502;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of RNA biosynthetic process#GO:1902680;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;regulation of angiogenesis#GO:0045765;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;regulation of developmental process#GO:0050793 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218 Gonadotropin-releasing hormone receptor pathway#P06664>GATA2/4#P06859 HUMAN|HGNC=24181|UniProtKB=Q7Z5L3 Q7Z5L3 C1QL2 PTHR22923:SF69 CEREBELLIN-RELATED COMPLEMENT C1Q-LIKE PROTEIN 2 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=28200|UniProtKB=Q96H86 Q96H86 ZNF764 PTHR24381:SF299 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 764 DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=16983|UniProtKB=Q8TAK6 Q8TAK6 OLIG1 PTHR19290:SF7 BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED OLIGODENDROCYTE TRANSCRIPTION FACTOR 1 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 head development#GO:0060322;nervous system development#GO:0007399;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;neuron projection development#GO:0031175;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;animal organ development#GO:0048513;neuron differentiation#GO:0030182;positive regulation of transcription by RNA polymerase II#GO:0045944;cell development#GO:0048468;cell projection organization#GO:0030030;regulation of transcription by RNA polymerase II#GO:0006357;central nervous system development#GO:0007417;cell differentiation#GO:0030154;forebrain development#GO:0030900;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;neuron development#GO:0048666;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;regulation of nucleobase-containing compound metabolic process#GO:0019219;brain development#GO:0007420;positive regulation of DNA-templated transcription#GO:0045893;multicellular organismal process#GO:0032501;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;axon development#GO:0061564;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;developmental process#GO:0032502;sensory organ development#GO:0007423;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=21638|UniProtKB=Q5SZL2 Q5SZL2 CEP85L PTHR31075:SF2 CENTROSOMAL PROTEIN OF 85 KDA CENTROSOMAL PROTEIN OF 85 KDA-LIKE microtubule organizing center#GO:0005815;centrosome#GO:0005813;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;microtubule cytoskeleton#GO:0015630;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232 HUMAN|HGNC=26546|UniProtKB=Q2M243 Q2M243 CCDC27 PTHR18853:SF9 FORKHEAD-ASSOCIATED DOMAIN-CONTAINING PROTEIN 1-RELATED COILED-COIL DOMAIN-CONTAINING PROTEIN 27 helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246;DNA-binding transcription factor#PC00218 HUMAN|HGNC=24604|UniProtKB=Q9NYJ1 Q9NYJ1 COA4 PTHR13639:SF2 CYTOCHROME C OXIDASE ASSEMBLY FACTOR 4 HOMOLOG, MITOCHONDRIAL CYTOCHROME C OXIDASE ASSEMBLY FACTOR 4 HOMOLOG, MITOCHONDRIAL respiratory chain complex IV assembly#GO:0008535;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;cytochrome complex assembly#GO:0017004;mitochondrial respiratory chain complex IV assembly#GO:0033617;mitochondrial respiratory chain complex assembly#GO:0033108;mitochondrion organization#GO:0007005;cellular component assembly#GO:0022607;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043 chaperone#PC00072 HUMAN|HGNC=28087|UniProtKB=Q8NCT1 Q8NCT1 ARRDC4 PTHR11188:SF16 ARRESTIN DOMAIN CONTAINING PROTEIN ARRESTIN DOMAIN-CONTAINING PROTEIN 4 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;enzyme-substrate adaptor activity#GO:0140767;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=28556|UniProtKB=Q8N0W5 Q8N0W5 IQCK PTHR34927:SF1 IQ DOMAIN-CONTAINING PROTEIN K IQ DOMAIN-CONTAINING PROTEIN K HUMAN|HGNC=1321|UniProtKB=Q9NPL8 Q9NPL8 TIMMDC1 PTHR13002:SF1 C3ORF1 PROTEIN-RELATED COMPLEX I ASSEMBLY FACTOR TIMMDC1, MITOCHONDRIAL intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HUMAN|HGNC=20423|UniProtKB=Q9P0W8 Q9P0W8 SPATA7 PTHR14917:SF2 SPERMATOGENESIS-ASSOCIATED PROTEIN 7 SPERMATOGENESIS-ASSOCIATED PROTEIN 7 tissue homeostasis#GO:0001894;multicellular organismal-level homeostasis#GO:0048871;microtubule-based process#GO:0007017;retina homeostasis#GO:0001895;cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226;cytoskeleton organization#GO:0007010;homeostatic process#GO:0042592;anatomical structure homeostasis#GO:0060249;multicellular organismal process#GO:0032501;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043 microtubule organizing center#GO:0005815;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;9+0 non-motile cilium#GO:0097731;neuron projection#GO:0043005;photoreceptor cell cilium#GO:0097733;ciliary plasm#GO:0097014;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;ciliary transition zone#GO:0035869;cilium#GO:0005929;intracellular organelle#GO:0043229;axoneme#GO:0005930;membrane-bounded organelle#GO:0043227;non-motile cilium#GO:0097730;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;photoreceptor outer segment#GO:0001750;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025 HUMAN|HGNC=25069|UniProtKB=Q6PJ61 Q6PJ61 FBXO46 PTHR16271:SF10 F-BOX ONLY PROTEIN 34/46 FAMILY MEMBER F-BOX ONLY PROTEIN 46 HUMAN|HGNC=11837|UniProtKB=Q04724 Q04724 TLE1 PTHR10814:SF29 TRANSDUCIN-LIKE ENHANCER PROTEIN TRANSDUCIN-LIKE ENHANCER PROTEIN 1 transcription regulator activity#GO:0140110;transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712 regulation of canonical Wnt signaling pathway#GO:0060828;negative regulation of response to stimulus#GO:0048585;negative regulation of Wnt signaling pathway#GO:0030178;negative regulation of signal transduction#GO:0009968;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of Wnt signaling pathway#GO:0030111;regulation of cell communication#GO:0010646;negative regulation of signaling#GO:0023057;negative regulation of canonical Wnt signaling pathway#GO:0090090;regulation of signaling#GO:0023051;negative regulation of cell communication#GO:0010648 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 transcription cofactor#PC00217 Wnt signaling pathway#P00057>Transducin-like Enhance of Split 1-3#P01436 HUMAN|HGNC=3326|UniProtKB=P28324 P28324 ELK4 PTHR11849:SF21 ETS ETS DOMAIN-CONTAINING PROTEIN ELK-4 transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;cellular process#GO:0009987;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;developmental process#GO:0032502 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 winged helix/forkhead transcription factor#PC00246;DNA-binding transcription factor#PC00218 PDGF signaling pathway#P00047>ELK#P01140;CCKR signaling map#P06959>SAP1#P07097;Interleukin signaling pathway#P00036>ELK#P00962 HUMAN|HGNC=20854|UniProtKB=Q9H0W7 Q9H0W7 THAP2 PTHR47696:SF1 THAP DOMAIN-CONTAINING PROTEIN 2 THAP DOMAIN-CONTAINING PROTEIN 2 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=842|UniProtKB=Q06055 Q06055 ATP5MC2 PTHR10031:SF54 ATP SYNTHASE LIPID-BINDING PROTEIN, MITOCHONDRIAL ATP SYNTHASE F(0) COMPLEX SUBUNIT C2, MITOCHONDRIAL ATP synthase#PC00002;primary active transporter#PC00068;transporter#PC00227 HUMAN|HGNC=26920|UniProtKB=Q96G46 Q96G46 DUS3L PTHR45846:SF1 TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;oxidoreductase activity#GO:0016491;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 RNA processing factor#PC00147 HUMAN|HGNC=6783|UniProtKB=P20916 P20916 MAG PTHR12035:SF107 SIALIC ACID BINDING IMMUNOGLOBULIN-LIKE LECTIN MYELIN-ASSOCIATED GLYCOPROTEIN anion binding#GO:0043168;small molecule binding#GO:0036094;binding#GO:0005488;carboxylic acid binding#GO:0031406;carbohydrate derivative binding#GO:0097367;ion binding#GO:0043167;organic acid binding#GO:0043177 cellular process#GO:0009987;cell adhesion#GO:0007155 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 cell adhesion molecule#PC00069;immunoglobulin superfamily cell adhesion molecule#PC00125 HUMAN|HGNC=8572|UniProtKB=Q9UKS6 Q9UKS6 PACSIN3 PTHR23065:SF18 PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1 PROTEIN KINASE C AND CASEIN KINASE SUBSTRATE IN NEURONS PROTEIN 3 lipid binding#GO:0008289;binding#GO:0005488;phospholipid binding#GO:0005543 plasma membrane organization#GO:0007009;cellular component organization or biogenesis#GO:0071840;regulation of localization#GO:0032879;regulation of transport#GO:0051049;regulation of endocytosis#GO:0030100;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;regulation of biological process#GO:0050789 membrane#GO:0016020;intracellular vesicle#GO:0097708;cell periphery#GO:0071944;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;plasma membrane#GO:0005886;endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 actin or actin-binding cytoskeletal protein#PC00041;cytoskeletal protein#PC00085 HUMAN|HGNC=12936|UniProtKB=Q13105 Q13105 ZBTB17 PTHR24399:SF8 ZINC FINGER AND BTB DOMAIN-CONTAINING ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 17 double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;nucleic acid binding#GO:0003676;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription repressor activity#GO:0001217;transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of cytokine production#GO:0001817;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122 organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=14958|UniProtKB=Q8TB72 Q8TB72 PUM2 PTHR12537:SF52 RNA BINDING PROTEIN PUMILIO-RELATED PUMILIO HOMOLOG 2 mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA 3'-UTR binding#GO:0003730;RNA binding#GO:0003723 regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;regulation of mRNA stability#GO:0043488;negative regulation of metabolic process#GO:0009892;miRNA processing#GO:0035196;nucleic acid biosynthetic process#GO:0141187;regulation of biological quality#GO:0065008;RNA metabolic process#GO:0016070;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;RNA processing#GO:0006396;gene expression#GO:0010467;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;regulation of mRNA metabolic process#GO:1903311;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA stability#GO:0043487;regulation of RNA metabolic process#GO:0051252;macromolecule biosynthetic process#GO:0009059;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;biosynthetic process#GO:0009058;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulatory ncRNA-mediated gene silencing#GO:0031047;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulatory ncRNA processing#GO:0070918 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031 HUMAN|HGNC=15881|UniProtKB=Q9BQY9 Q9BQY9 DBNDD2 PTHR16294:SF7 DYSTROBREVIN BINDING PROTEIN 1 DYSBINDIN DYSBINDIN DOMAIN-CONTAINING PROTEIN 2 regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966 HUMAN|HGNC=11498|UniProtKB=O43759 O43759 SYNGR1 PTHR10838:SF7 SYNAPTOGYRIN SYNAPTOGYRIN-1 secretion by cell#GO:0032940;exocytosis#GO:0006887;establishment of localization#GO:0051234;secretion#GO:0046903;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;transport#GO:0006810;regulated exocytosis#GO:0045055;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;export from cell#GO:0140352;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;cellular component organization#GO:0016043;synaptic vesicle membrane organization#GO:0048499 transport vesicle#GO:0030133;endomembrane system#GO:0012505;cytoplasm#GO:0005737;secretory vesicle#GO:0099503;presynapse#GO:0098793;cell junction#GO:0030054;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;synaptic vesicle#GO:0008021;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382 membrane trafficking regulatory protein#PC00151;membrane traffic protein#PC00150 HUMAN|HGNC=30483|UniProtKB=Q96MG8 Q96MG8 PCMTD1 PTHR11579:SF4 PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN 1 catalytic activity, acting on a protein#GO:0140096;protein methyltransferase activity#GO:0008276;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741;O-methyltransferase activity#GO:0008171;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 methyltransferase#PC00155;transferase#PC00220 HUMAN|HGNC=14288|UniProtKB=Q96CW9 Q96CW9 NTNG2 PTHR10574:SF27 NETRIN/LAMININ-RELATED NETRIN-G2 anatomical structure development#GO:0048856;system development#GO:0048731;neuron development#GO:0048666;axonogenesis#GO:0007409;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell morphogenesis#GO:0000902;cell development#GO:0048468;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;cell projection morphogenesis#GO:0048858;neurogenesis#GO:0022008;neuron differentiation#GO:0030182;developmental process#GO:0032502;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;tissue development#GO:0009888;plasma membrane bounded cell projection organization#GO:0120036;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;neuron projection development#GO:0031175;axon development#GO:0061564;cellular process#GO:0009987 extracellular matrix protein#PC00102 Axon guidance mediated by Slit/Robo#P00008>Netrin#P00344;Axon guidance mediated by netrin#P00009>Netrin#P00357 HUMAN|HGNC=8786|UniProtKB=P35913 P35913 PDE6B PTHR11347:SF73 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE ROD CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT BETA phosphoric ester hydrolase activity#GO:0042578;phosphoric diester hydrolase activity#GO:0008081;hydrolase activity#GO:0016787;cyclic-nucleotide phosphodiesterase activity#GO:0004112;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788 negative regulation of cell communication#GO:0010648;eye development#GO:0001654;system development#GO:0048731;anatomical structure development#GO:0048856;negative regulation of intracellular signal transduction#GO:1902532;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;animal gross anatomical part developmental process#GO:0160108;negative regulation of signaling#GO:0023057;camera-type eye development#GO:0043010;regulation of cell communication#GO:0010646;visual system development#GO:0150063;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;animal organ development#GO:0048513;multicellular organism development#GO:0007275;regulation of response to stimulus#GO:0048583;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;sensory organ development#GO:0007423;negative regulation of signal transduction#GO:0009968;retina development in camera-type eye#GO:0060041;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of response to stimulus#GO:0048585;multicellular organismal process#GO:0032501;sensory system development#GO:0048880 cellular anatomical structure#GO:0110165;photoreceptor outer segment#GO:0001750;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cell projection membrane#GO:0031253;non-motile cilium#GO:0097730;membrane-bounded organelle#GO:0043227;cilium#GO:0005929;plasma membrane region#GO:0098590;ciliary membrane#GO:0060170;plasma membrane#GO:0005886;membrane#GO:0016020;9+0 non-motile cilium#GO:0097731;photoreceptor cell cilium#GO:0097733;cell periphery#GO:0071944;neuron projection#GO:0043005;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090 hydrolase#PC00121;phosphodiesterase#PC00185 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>PDEalphabeta#P00759 HUMAN|HGNC=8873|UniProtKB=O60825 O60825 PFKFB2 PTHR10606:SF48 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE 6-PHOSPHOFRUCTO-2-KINASE_FRUCTOSE-2,6-BISPHOSPHATASE 2 phosphatase activity#GO:0016791;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;hydrolase activity, acting on ester bonds#GO:0016788;carbohydrate kinase activity#GO:0019200;transferase activity#GO:0016740;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578;sugar-phosphatase activity#GO:0050308;hydrolase activity#GO:0016787;phosphotransferase activity, alcohol group as acceptor#GO:0016773 phosphorus metabolic process#GO:0006793;organophosphate metabolic process#GO:0019637;metabolic process#GO:0008152;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 phosphatase#PC00181;hydrolase#PC00121;carbohydrate phosphatase#PC00066 HUMAN|HGNC=22947|UniProtKB=Q8WX94 Q8WX94 NLRP7 PTHR45690:SF20 NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12 NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 7 regulation of response to stress#GO:0080134;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cytokine production#GO:0001817;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;regulation of response to external stimulus#GO:0032101;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of multicellular organismal process#GO:0051239;regulation of inflammatory response#GO:0050727;regulation of defense response#GO:0031347;negative regulation of multicellular organismal process#GO:0051241;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090 HUMAN|HGNC=15572|UniProtKB=Q9BQQ7 Q9BQQ7 RTP3 PTHR14402:SF9 RECEPTOR TRANSPORTING PROTEIN RECEPTOR-TRANSPORTING PROTEIN 3 signaling receptor binding#GO:0005102;binding#GO:0005488;G protein-coupled receptor binding#GO:0001664;protein binding#GO:0005515 sensory perception of taste#GO:0050909;protein targeting to membrane#GO:0006612;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;intracellular protein localization#GO:0008104;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;detection of chemical stimulus involved in sensory perception of bitter taste#GO:0001580;establishment of protein localization#GO:0045184;cellular process#GO:0009987;macromolecule localization#GO:0033036;detection of stimulus involved in sensory perception#GO:0050906;establishment of protein localization to membrane#GO:0090150;detection of stimulus#GO:0051606;membrane organization#GO:0061024;response to chemical#GO:0042221;protein insertion into membrane#GO:0051205;multicellular organismal process#GO:0032501;localization within membrane#GO:0051668;sensory perception#GO:0007600;detection of chemical stimulus involved in sensory perception of taste#GO:0050912;nervous system process#GO:0050877;detection of chemical stimulus involved in sensory perception#GO:0050907;localization#GO:0051179;cellular localization#GO:0051641;detection of chemical stimulus#GO:0009593;sensory perception of bitter taste#GO:0050913;cellular component organization#GO:0016043;response to stimulus#GO:0050896;protein targeting#GO:0006605 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 membrane traffic protein#PC00150 HUMAN|HGNC=16411|UniProtKB=Q8WV93 Q8WV93 AFG1L PTHR12169:SF6 ATPASE N2B AFG1-LIKE ATPASE ATP-dependent activity#GO:0140657;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP hydrolysis activity#GO:0016887;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=18532|UniProtKB=Q8NHZ7 Q8NHZ7 MBD3L2 PTHR12396:SF6 METHYL-CPG BINDING PROTEIN, MBD METHYL-CPG-BINDING DOMAIN PROTEIN 3-LIKE 2-RELATED negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of gene expression, epigenetic#GO:0045814;cellular component organization or biogenesis#GO:0071840;DNA methylation-dependent constitutive heterochromatin formation#GO:0006346;constitutive heterochromatin formation#GO:0140719;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;cellular component assembly#GO:0022607;heterochromatin organization#GO:0070828;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;heterochromatin formation#GO:0031507;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of cellular process#GO:0048523;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;epigenetic regulation of gene expression#GO:0040029;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;chromatin organization#GO:0006325 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=3231|UniProtKB=Q9HCU4 Q9HCU4 CELSR2 PTHR24026:SF32 FAT ATYPICAL CADHERIN-RELATED CADHERIN EGF LAG SEVEN-PASS G-TYPE RECEPTOR 2 plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron projection morphogenesis#GO:0048812;neuron differentiation#GO:0030182;developmental process#GO:0032502;neurogenesis#GO:0022008;cell projection morphogenesis#GO:0048858;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cellular process#GO:0009987;axon development#GO:0061564;cell-cell adhesion#GO:0098609;neuron projection development#GO:0031175;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;multicellular organismal process#GO:0032501;cell adhesion#GO:0007155;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;neuron development#GO:0048666;axonogenesis#GO:0007409;system development#GO:0048731;anatomical structure development#GO:0048856;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;cell development#GO:0048468;cell morphogenesis#GO:0000902;cell differentiation#GO:0030154;cell projection organization#GO:0030030 adherens junction#GO:0005912;anchoring junction#GO:0070161;cell junction#GO:0030054;cellular anatomical structure#GO:0110165;cell-cell junction#GO:0005911 cadherin#PC00057 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HUMAN|HGNC=30405|UniProtKB=Q8NF86 Q8NF86 PRSS33 PTHR24256:SF219 TRYPTASE-RELATED SERINE PROTEASE 33 endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;serine-type peptidase activity#GO:0008236 metabolic process#GO:0008152;proteolysis#GO:0006508;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 serine protease#PC00203 HUMAN|HGNC=31043|UniProtKB=P0C7Q5 P0C7Q5 SLC35G4 PTHR22911:SF32 ACYL-MALONYL CONDENSING ENZYME-RELATED SOLUTE CARRIER FAMILY 35 MEMBER G4-RELATED membrane#GO:0016020;cellular anatomical structure#GO:0110165 transporter#PC00227 HUMAN|HGNC=15719|UniProtKB=Q5VST9 Q5VST9 OBSCN PTHR35971:SF4 SI:DKEY-31G6.6 OBSCURIN phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;protein kinase activity#GO:0004672;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 intracellular organelle#GO:0043229;M band#GO:0031430;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;myofibril#GO:0030016;A band#GO:0031672;cellular anatomical structure#GO:0110165;organelle#GO:0043226;I band#GO:0031674;membraneless organelle#GO:0043228;sarcomere#GO:0030017;sarcolemma#GO:0042383;cell periphery#GO:0071944;Z disc#GO:0030018;contractile muscle fiber#GO:0043292;membrane#GO:0016020;cytoplasm#GO:0005737;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080 HUMAN|HGNC=21154|UniProtKB=Q8WVZ7 Q8WVZ7 RNF133 PTHR22765:SF38 RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING E3 UBIQUITIN-PROTEIN LIGASE RNF133 acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 organelle#GO:0043226;late endosome#GO:0005770;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular vesicle#GO:0097708;vesicle#GO:0031982;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;endosome#GO:0005768 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=11870|UniProtKB=P82094 P82094 TMF1 PTHR46515:SF1 TATA ELEMENT MODULATORY FACTOR TMF1 TATA ELEMENT MODULATORY FACTOR organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 HUMAN|HGNC=29238|UniProtKB=Q9ULD9 Q9ULD9 ZNF608 PTHR21564:SF4 BRAKELESS PROTEIN ZINC FINGER PROTEIN 608 regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=11749|UniProtKB=Q14186 Q14186 TFDP1 PTHR12548:SF4 TRANSCRIPTION FACTOR DP TRANSCRIPTION FACTOR DP-1 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=19296|UniProtKB=Q9UF33 Q9UF33 EPHA6 PTHR46877:SF10 EPH RECEPTOR A5 EPHRIN TYPE-A RECEPTOR 6 transmembrane receptor protein kinase activity#GO:0019199;signaling receptor activity#GO:0038023;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein tyrosine kinase activity#GO:0004713;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein kinase activity#GO:0004672;molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane signaling receptor activity#GO:0004888 plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;axon guidance#GO:0007411;axon development#GO:0061564;neurogenesis#GO:0022008;neuron projection guidance#GO:0097485;cellular developmental process#GO:0048869;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;regulation of cellular process#GO:0050794;ephrin receptor signaling pathway#GO:0048013;cellular response to stimulus#GO:0051716;system development#GO:0048731;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;cell communication#GO:0007154;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;cellular process#GO:0009987;signal transduction#GO:0007165;neuron projection development#GO:0031175;cell projection morphogenesis#GO:0048858;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cell surface receptor signaling pathway#GO:0007166;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;cell development#GO:0048468;signaling#GO:0023052;cell morphogenesis#GO:0000902;response to stimulus#GO:0050896;cell projection organization#GO:0030030;cell differentiation#GO:0030154;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;axonogenesis#GO:0007409;neuron development#GO:0048666;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108 membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cell projection#GO:0042995;somatodendritic compartment#GO:0036477;plasma membrane bounded cell projection#GO:0120025;dendrite#GO:0030425;dendritic tree#GO:0097447 transmembrane signal receptor#PC00197 HUMAN|HGNC=10027|UniProtKB=P04090 P04090 RLN2 PTHR12004:SF13 RELAXIN PRORELAXIN H2 intercellular signal molecule#PC00207;peptide hormone#PC00179 HUMAN|HGNC=7732|UniProtKB=Q15843 Q15843 NEDD8 PTHR10666:SF173 UBIQUITIN UBIQUITIN-LIKE PROTEIN NEDD8 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 protein modification by small protein conjugation or removal#GO:0070647;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;protein modification process#GO:0036211;regulation of biological process#GO:0050789;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;regulation of proteolysis#GO:0030162;macromolecule metabolic process#GO:0043170;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;post-translational protein modification#GO:0043687;biological regulation#GO:0065007;protein ubiquitination#GO:0016567 cytosolic ribosome#GO:0022626;cytosol#GO:0005829;ribosome#GO:0005840;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=17412|UniProtKB=Q9UBD9 Q9UBD9 CLCF1 PTHR21353:SF7 FAMILY NOT NAMED CARDIOTROPHIN-LIKE CYTOKINE FACTOR 1 signaling receptor regulator activity#GO:0030545;cytokine activity#GO:0005125;receptor ligand activity#GO:0048018;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772 positive regulation of mononuclear cell proliferation#GO:0032946;regulation of leukocyte proliferation#GO:0070663;regulation of B cell proliferation#GO:0030888;positive regulation of leukocyte activation#GO:0002696;cell surface receptor signaling pathway#GO:0007166;cell surface receptor signaling pathway via STAT#GO:0097696;regulation of multicellular organismal process#GO:0051239;positive regulation of immune system process#GO:0002684;regulation of mononuclear cell proliferation#GO:0032944;regulation of B cell activation#GO:0050864;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;response to stimulus#GO:0050896;regulation of lymphocyte activation#GO:0051249;signaling#GO:0023052;regulation of leukocyte activation#GO:0002694;positive regulation of cell population proliferation#GO:0008284;positive regulation of multicellular organismal process#GO:0051240;regulation of cell activation#GO:0050865;regulation of biological process#GO:0050789;positive regulation of leukocyte proliferation#GO:0070665;cell surface receptor signaling pathway via JAK-STAT#GO:0007259;regulation of lymphocyte proliferation#GO:0050670;positive regulation of cell activation#GO:0050867;biological regulation#GO:0065007;positive regulation of cellular process#GO:0048522;regulation of cell population proliferation#GO:0042127;positive regulation of lymphocyte activation#GO:0051251;cell communication#GO:0007154;positive regulation of lymphocyte proliferation#GO:0050671;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;positive regulation of B cell proliferation#GO:0030890;cellular response to stimulus#GO:0051716 extracellular region#GO:0005576;extracellular protein-containing complex#GO:0140392;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 HUMAN|HGNC=33113|UniProtKB=A8MUP2 A8MUP2 CSKMT PTHR12176:SF83 SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN CITRATE SYNTHASE-LYSINE N-METHYLTRANSFERASE CSKMT, MITOCHONDRIAL lysine N-methyltransferase activity#GO:0016278;N-methyltransferase activity#GO:0008170;protein-lysine N-methyltransferase activity#GO:0016279;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;catalytic activity, acting on a protein#GO:0140096;protein methyltransferase activity#GO:0008276;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity#GO:0003824;transferase activity#GO:0016740 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 methyltransferase#PC00155;transferase#PC00220;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=25760|UniProtKB=Q8IV32 Q8IV32 CCDC71 PTHR14484:SF0 COILED-COIL DOMAIN-CONTAINING PROTEIN 71 COILED-COIL DOMAIN-CONTAINING PROTEIN 71 HUMAN|HGNC=28210|UniProtKB=Q86UY5 Q86UY5 FAM83A PTHR16181:SF34 PROTEIN FAM83A-RELATED PROTEIN FAM83A protein binding#GO:0005515;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;kinase binding#GO:0019900;binding#GO:0005488 cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;ERBB signaling pathway#GO:0038127;cellular response to stimulus#GO:0051716;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;epidermal growth factor receptor signaling pathway#GO:0007173 HUMAN|HGNC=10055|UniProtKB=Q8N5U6 Q8N5U6 RNF10 PTHR12983:SF10 RING FINGER 10 FAMILY MEMBER E3 UBIQUITIN-PROTEIN LIGASE RNF10 transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659 regulation of developmental process#GO:0050793;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;modification-dependent protein catabolic process#GO:0019941;regulation of multicellular organismal development#GO:2000026;positive regulation of multicellular organismal process#GO:0051240;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;regulation of nervous system development#GO:0051960;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;biological regulation#GO:0065007;regulation of multicellular organismal process#GO:0051239;proteasomal protein catabolic process#GO:0010498;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;regulation of system process#GO:0044057;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 HUMAN|HGNC=8919|UniProtKB=O43189 O43189 PHF1 PTHR12628:SF11 POLYCOMB-LIKE TRANSCRIPTION FACTOR PHD FINGER PROTEIN 1 DNA binding#GO:0003677;chromatin binding#GO:0003682;binding#GO:0005488;nucleic acid binding#GO:0003676 negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;negative regulation of cellular process#GO:0048523;cellular component organization or biogenesis#GO:0071840;negative regulation of gene expression, epigenetic#GO:0045814;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of macromolecule biosynthetic process#GO:0010558;epigenetic regulation of gene expression#GO:0040029;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;chromatin organization#GO:0006325;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=30688|UniProtKB=Q86VP6 Q86VP6 CAND1 PTHR12696:SF1 TIP120 CULLIN-ASSOCIATED NEDD8-DISSOCIATED PROTEIN 1 metabolic process#GO:0008152;protein-containing complex organization#GO:0043933;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;cellular component assembly#GO:0022607;protein modification by small protein conjugation or removal#GO:0070647;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;protein-containing complex assembly#GO:0065003;protein modification by small protein conjugation#GO:0032446;cellular component organization#GO:0016043;protein modification process#GO:0036211;primary metabolic process#GO:0044238 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=13243|UniProtKB=Q8WVP7 Q8WVP7 LMBR1 PTHR12625:SF1 LIPOCALIN-1 INTERACTING MEMBRANE RECEPTOR LIMR LIMB REGION 1 PROTEIN HOMOLOG transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell communication#GO:0007154;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=13253|UniProtKB=Q9UBR5 Q9UBR5 CKLF PTHR22776:SF45 MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN CHEMOKINE-LIKE FACTOR cytokine receptor binding#GO:0005126;signaling receptor binding#GO:0005102;binding#GO:0005488;cytokine activity#GO:0005125;molecular function activator activity#GO:0140677;protein binding#GO:0005515;chemokine receptor binding#GO:0042379;chemokine activity#GO:0008009;G protein-coupled receptor binding#GO:0001664;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772 neutrophil chemotaxis#GO:0030593;leukocyte migration#GO:0050900;response to external stimulus#GO:0009605;myeloid leukocyte migration#GO:0097529;leukocyte chemotaxis#GO:0030595;lymphocyte migration#GO:0072676;immune response#GO:0006955;cellular process#GO:0009987;neutrophil migration#GO:1990266;taxis#GO:0042330;response to chemical#GO:0042221;cell migration#GO:0016477;granulocyte migration#GO:0097530;biological regulation#GO:0065007;cellular response to chemical stimulus#GO:0070887;immune system process#GO:0002376;mononuclear cell migration#GO:0071674;chemotaxis#GO:0006935;cell chemotaxis#GO:0060326;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;granulocyte chemotaxis#GO:0071621;cell motility#GO:0048870;signaling#GO:0023052;locomotion#GO:0040011 membrane#GO:0016020;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=117|UniProtKB=P21399 P21399 ACO1 PTHR11670:SF32 ACONITASE/IRON-RESPONSIVE ELEMENT FAMILY MEMBER CYTOPLASMIC ACONITATE HYDRATASE carbon-oxygen lyase activity#GO:0016835;hydro-lyase activity#GO:0016836;catalytic activity#GO:0003824;RNA binding#GO:0003723;lyase activity#GO:0016829;iron-sulfur cluster binding#GO:0051536;small molecule binding#GO:0036094;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729 intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;inorganic ion homeostasis#GO:0098771;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;homeostatic process#GO:0042592;small molecule metabolic process#GO:0044281;intracellular iron ion homeostasis#GO:0006879;cellular process#GO:0009987;intracellular monoatomic ion homeostasis#GO:0006873;carboxylic acid metabolic process#GO:0019752;monoatomic ion homeostasis#GO:0050801 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 Methylcitrate cycle#P02754>Aconitase#P03028 HUMAN|HGNC=21151|UniProtKB=Q9BV68 Q9BV68 RNF126 PTHR15710:SF21 E3 UBIQUITIN-PROTEIN LIGASE PRAJA E3 UBIQUITIN-PROTEIN LIGASE RNF126 ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740 cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;cellular response to topologically incorrect protein#GO:0035967;protein metabolic process#GO:0019538;modification-dependent protein catabolic process#GO:0019941;cellular response to stimulus#GO:0051716;response to misfolded protein#GO:0051788;primary metabolic process#GO:0044238;response to topologically incorrect protein#GO:0035966;protein quality control for misfolded or incompletely synthesized proteins#GO:0006515;response to stimulus#GO:0050896;catabolic process#GO:0009056;cellular response to misfolded protein#GO:0071218;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;response to stress#GO:0006950;proteasomal protein catabolic process#GO:0010498 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=16982|UniProtKB=Q9Y4C4 Q9Y4C4 MFHAS1 PTHR45752:SF48 LEUCINE-RICH REPEAT-CONTAINING MALIGNANT FIBROUS HISTIOCYTOMA-AMPLIFIED SEQUENCE 1 regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;inflammatory response#GO:0006954;immune system process#GO:0002376;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;defense response to symbiont#GO:0140546;immune response#GO:0006955;signal transduction#GO:0007165;cellular process#GO:0009987;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;biological regulation#GO:0065007;response to other organism#GO:0051707;defense response to other organism#GO:0098542;response to external stimulus#GO:0009605;defense response#GO:0006952;innate immune response#GO:0045087 scaffold/adaptor protein#PC00226 HUMAN|HGNC=28150|UniProtKB=Q6UXH1 Q6UXH1 CRELD2 PTHR24034:SF110 EGF-LIKE DOMAIN-CONTAINING PROTEIN PROTEIN DISULFIDE ISOMERASE CRELD2 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 extracellular matrix structural protein#PC00103;extracellular matrix protein#PC00102 HUMAN|HGNC=14239|UniProtKB=Q9BYW1 Q9BYW1 SLC2A11 PTHR23503:SF22 SOLUTE CARRIER FAMILY 2 SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 11 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;sugar transmembrane transporter activity#GO:0051119;carbohydrate transmembrane transporter activity#GO:0015144 transmembrane transport#GO:0055085;import into cell#GO:0098657;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810;carbohydrate transport#GO:0008643;carbohydrate transmembrane transport#GO:0034219;vitamin transport#GO:0051180;import across plasma membrane#GO:0098739;cellular process#GO:0009987;D-glucose transmembrane transport#GO:1904659 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 secondary carrier transporter#PC00258 HUMAN|HGNC=24683|UniProtKB=Q969F0 Q969F0 FATE1 PTHR21128:SF0 FETAL AND ADULT TESTIS-EXPRESSED TRANSCRIPT PROTEIN FETAL AND ADULT TESTIS-EXPRESSED TRANSCRIPT PROTEIN ubiquitin-like protein ligase binding#GO:0044389;binding#GO:0005488;enzyme binding#GO:0019899;protein binding#GO:0005515;ubiquitin protein ligase binding#GO:0031625 cellular homeostasis#GO:0019725;intracellular calcium ion homeostasis#GO:0006874;intracellular chemical homeostasis#GO:0055082;regulation of apoptotic process#GO:0042981;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;negative regulation of apoptotic process#GO:0043066;negative regulation of programmed cell death#GO:0043069;monoatomic ion homeostasis#GO:0050801;inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;homeostatic process#GO:0042592;mitochondrial calcium ion homeostasis#GO:0051560;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;intracellular monoatomic ion homeostasis#GO:0006873;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519 organelle membrane contact site#GO:0044232;organelle envelope#GO:0031967;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;outer membrane#GO:0019867;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;endomembrane system#GO:0012505;organelle outer membrane#GO:0031968;cytoplasm#GO:0005737;mitochondria-associated endoplasmic reticulum membrane contact site#GO:0044233;endoplasmic reticulum#GO:0005783;mitochondrial outer membrane#GO:0005741;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090 HUMAN|HGNC=917|UniProtKB=O43825 O43825 B3GALT2 PTHR11214:SF19 BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE BETA-1,3-GALACTOSYLTRANSFERASE 2 transferase activity#GO:0016740;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194;galactosyltransferase activity#GO:0008378 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 glycosyltransferase#PC00111;transferase#PC00220 HUMAN|HGNC=28434|UniProtKB=Q8N1B3 Q8N1B3 CCNQ PTHR10026:SF70 CYCLIN CYCLIN-Q cyclin-dependent protein kinase regulator activity#GO:0019914;protein kinase regulator activity#GO:0019887;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;enzyme regulator activity#GO:0030234;cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 kinase modulator#PC00140;kinase activator#PC00138 HUMAN|HGNC=21386|UniProtKB=Q8N475 Q8N475 FSTL5 PTHR10913:SF44 FOLLISTATIN-RELATED FOLLISTATIN-RELATED PROTEIN 5 cellular developmental process#GO:0048869;cell differentiation#GO:0030154;cellular process#GO:0009987;developmental process#GO:0032502 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease inhibitor#PC00191 HUMAN|HGNC=8669|UniProtKB=Q9Y5H8 Q9Y5H8 PCDHA3 PTHR24028:SF327 CADHERIN-87A PROTOCADHERIN ALPHA-3 cell adhesion#GO:0007155;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cadherin#PC00057;cell adhesion molecule#PC00069 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HUMAN|HGNC=51511|UniProtKB=P0DUD4 P0DUD4 SPDYE15 PTHR31156:SF15 WBSCR19-LIKE PROTEIN SPEEDY PROTEIN E10-RELATED HUMAN|HGNC=12225|UniProtKB=A0A5A2 A0A5A2 TRBV5-8 PTHR23268:SF123 T-CELL RECEPTOR BETA CHAIN T CELL RECEPTOR BETA VARIABLE 5-8 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=30480|UniProtKB=A8MVW0 A8MVW0 FAM171A2 PTHR31626:SF3 SUSHI DOMAIN-CONTAINING PROTEIN PROTEIN FAM171A2 HUMAN|HGNC=11171|UniProtKB=Q9Y675 Q9Y675 SNURF PTHR14508:SF2 SNRPN UPSTREAM READING FRAME PROTEIN, SNURF SNRPN UPSTREAM READING FRAME PROTEIN-RELATED intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear speck#GO:0016607;organelle lumen#GO:0043233;membraneless organelle#GO:0043228;nuclear body#GO:0016604;intracellular membraneless organelle#GO:0043232;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974 HUMAN|HGNC=557|UniProtKB=Q9UMZ2 Q9UMZ2 SYNRG PTHR15463:SF2 AP1 GAMMA SUBUNIT BINDING PROTEIN 1 SYNERGIN GAMMA membrane protein complex#GO:0098796;vesicle#GO:0031982;intracellular membrane-bounded organelle#GO:0043231;trans-Golgi network transport vesicle#GO:0030140;membrane coat#GO:0030117;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;vesicle membrane#GO:0012506;membrane#GO:0016020;transport vesicle#GO:0030133;endomembrane system#GO:0012505;transport vesicle membrane#GO:0030658;Golgi apparatus#GO:0005794;trans-Golgi network transport vesicle membrane#GO:0012510;Golgi-associated vesicle#GO:0005798;clathrin-coated vesicle#GO:0030136;organelle membrane#GO:0031090;intracellular vesicle#GO:0097708;organelle#GO:0043226;clathrin coat#GO:0030118;cellular anatomical structure#GO:0110165;coated vesicle membrane#GO:0030662;Golgi-associated vesicle membrane#GO:0030660;intracellular organelle#GO:0043229;coated membrane#GO:0048475;coated vesicle#GO:0030135;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;vesicle coat#GO:0030120;cytoplasm#GO:0005737;clathrin vesicle coat#GO:0030125;clathrin-coated vesicle membrane#GO:0030665;bounding membrane of organelle#GO:0098588 HUMAN|HGNC=20213|UniProtKB=Q9P0S2 Q9P0S2 COX16 PTHR17130:SF14 MITOCHONDRIAL OUTER MEMBRANE PROTEIN 25 CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX16 HOMOLOG, MITOCHONDRIAL mitochondrial respiratory chain complex assembly#GO:0033108;mitochondrion organization#GO:0007005;cellular component assembly#GO:0022607;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;respiratory chain complex IV assembly#GO:0008535;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;cytochrome complex assembly#GO:0017004;mitochondrial respiratory chain complex IV assembly#GO:0033617 intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;organelle envelope#GO:0031967;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739 HUMAN|HGNC=6337|UniProtKB=Q14953 Q14953 KIR2DS5 PTHR11738:SF195 MHC CLASS I NK CELL RECEPTOR KILLER CELL IMMUNOGLOBULIN-LIKE RECEPTOR 2DS3-RELATED transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;immune receptor activity#GO:0140375;signaling receptor activity#GO:0038023 regulation of immune response#GO:0050776;cell surface receptor signaling pathway#GO:0007166;regulation of response to stimulus#GO:0048583;cell communication#GO:0007154;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;immune response-regulating signaling pathway#GO:0002764;signaling#GO:0023052;immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=25563|UniProtKB=Q8WU58 Q8WU58 FAM222B PTHR16070:SF1 PROTEIN FAM222A-RELATED PROTEIN FAM222B HUMAN|HGNC=15710|UniProtKB=O75112 O75112 LDB3 PTHR24214:SF9 PDZ AND LIM DOMAIN PROTEIN ZASP LIM DOMAIN-BINDING PROTEIN 3 protein binding#GO:0005515;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779 actin filament-based process#GO:0030029;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;anatomical structure development#GO:0048856;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;muscle structure development#GO:0061061;circulatory system development#GO:0072359;developmental process#GO:0032502;animal organ development#GO:0048513;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;multicellular organismal process#GO:0032501;heart development#GO:0007507 cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;actomyosin#GO:0042641;Z disc#GO:0030018;contractile muscle fiber#GO:0043292;cell-cell junction#GO:0005911;adherens junction#GO:0005912;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;sarcomere#GO:0030017;cell junction#GO:0030054;actin filament#GO:0005884;I band#GO:0031674;cytoskeleton#GO:0005856;stress fiber#GO:0001725;cellular anatomical structure#GO:0110165;organelle#GO:0043226;actin cytoskeleton#GO:0015629;anchoring junction#GO:0070161;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;actin filament bundle#GO:0032432;myofibril#GO:0030016;intracellular organelle#GO:0043229 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=4942|UniProtKB=P01909 P01909 HLA-DQA1 PTHR19944:SF59 MHC CLASS II-RELATED HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DQ ALPHA 1 CHAIN protein-containing complex binding#GO:0044877;binding#GO:0005488;antigen binding#GO:0003823;peptide binding#GO:0042277 regulation of T cell activation#GO:0050863;cellular component assembly#GO:0022607;positive regulation of T cell activation#GO:0050870;regulation of multicellular organismal process#GO:0051239;positive regulation of immune system process#GO:0002684;positive regulation of cell-cell adhesion#GO:0022409;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;positive regulation of leukocyte activation#GO:0002696;regulation of lymphocyte activation#GO:0051249;cellular component organization#GO:0016043;regulation of leukocyte activation#GO:0002694;positive regulation of multicellular organismal process#GO:0051240;regulation of cell activation#GO:0050865;regulation of biological process#GO:0050789;protein-containing complex assembly#GO:0065003;immune system process#GO:0002376;regulation of cell adhesion#GO:0030155;positive regulation of response to stimulus#GO:0048584;positive regulation of cell activation#GO:0050867;biological regulation#GO:0065007;positive regulation of leukocyte cell-cell adhesion#GO:1903039;positive regulation of cellular process#GO:0048522;regulation of leukocyte cell-cell adhesion#GO:1903037;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of cell-cell adhesion#GO:0022407;positive regulation of cell adhesion#GO:0045785;antigen processing and presentation#GO:0019882;positive regulation of lymphocyte activation#GO:0051251;regulation of immune response#GO:0050776 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;lytic vacuole membrane#GO:0098852;lysosome#GO:0005764;plasma membrane protein complex#GO:0098797;vesicle#GO:0031982;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;endosome membrane#GO:0010008;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;late endosome#GO:0005770;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;vacuole#GO:0005773;plasma membrane#GO:0005886;membrane#GO:0016020;vesicle membrane#GO:0012506;cell periphery#GO:0071944;lysosomal membrane#GO:0005765;vacuolar membrane#GO:0005774;lytic vacuole#GO:0000323;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;late endosome membrane#GO:0031902 major histocompatibility complex protein#PC00149 T cell activation#P00053>MHC-antigen#P01316 HUMAN|HGNC=10903|UniProtKB=Q13291 Q13291 SLAMF1 PTHR12080:SF49 SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;immune response#GO:0006955;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;immune system process#GO:0002376;cell communication#GO:0007154 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=1328|UniProtKB=P20851 P20851 C4BPB PTHR45656:SF14 PROTEIN CBR-CLEC-78 C4B-BINDING PROTEIN BETA CHAIN morphogenesis of an epithelium#GO:0002009;multicellular organism development#GO:0007275;animal organ development#GO:0048513;developmental process#GO:0032502;tube development#GO:0035295;epithelium development#GO:0060429;multicellular organismal process#GO:0032501;tissue development#GO:0009888;morphogenesis of a branching structure#GO:0001763;multicellular organismal reproductive process#GO:0048609;tissue morphogenesis#GO:0048729;anatomical structure development#GO:0048856;animal gross anatomical part developmental process#GO:0160108;reproductive process#GO:0022414;animal organ morphogenesis#GO:0009887;anatomical structure morphogenesis#GO:0009653;multi-multicellular organism process#GO:0044706;tube morphogenesis#GO:0035239;developmental process involved in reproduction#GO:0003006 HUMAN|HGNC=12892|UniProtKB=Q9UJU3 Q9UJU3 ZNF112 PTHR24376:SF90 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 112 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HUMAN|HGNC=12221|UniProtKB=A0A0C4DH59 A0A0C4DH59 TRBV5-4 PTHR23268:SF95 T-CELL RECEPTOR BETA CHAIN T CELL RECEPTOR BETA VARIABLE 5-4 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=6569|UniProtKB=O00214 O00214 LGALS8 PTHR11346:SF22 GALECTIN GALECTIN-8 binding#GO:0005488;carbohydrate binding#GO:0030246 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 extracellular matrix protein#PC00102 HUMAN|HGNC=30812|UniProtKB=Q562F6 Q562F6 SGO2 PTHR21577:SF3 SHUGOSHIN SHUGOSHIN 2 reproductive process#GO:0022414;cell cycle#GO:0007049;meiosis I#GO:0007127;nuclear chromosome segregation#GO:0098813;meiotic cell cycle process#GO:1903046;cellular component organization#GO:0016043;cell cycle process#GO:0022402;organelle fission#GO:0048285;sister chromatid cohesion#GO:0007062;meiosis I cell cycle process#GO:0061982;nuclear division#GO:0000280;sexual reproduction#GO:0019953;mitotic sister chromatid cohesion#GO:0007064;organelle organization#GO:0006996;cellular process#GO:0009987;homologous chromosome segregation#GO:0045143;cellular component organization or biogenesis#GO:0071840;meiotic nuclear division#GO:0140013;meiotic sister chromatid cohesion#GO:0051177;chromosome organization#GO:0051276;meiotic chromosome segregation#GO:0045132;meiotic cell cycle#GO:0051321;chromosome segregation#GO:0007059 chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;chromosome, centromeric region#GO:0000775;condensed chromosome#GO:0000793;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;supramolecular complex#GO:0099080;cellular anatomical structure#GO:0110165;cohesin complex#GO:0008278;protein-containing complex#GO:0032991;kinetochore#GO:0000776;chromosome#GO:0005694;condensed chromosome, centromeric region#GO:0000779 centromere DNA-binding protein#PC00071 HUMAN|HGNC=27026|UniProtKB=Q569G3 Q569G3 C5orf47 PTHR38655:SF1 SIMILAR TO RIKEN CDNA 4930524B15 SIMILAR TO HUMAN CHROMOSOME 5 OPEN READING FRAME 47 HUMAN|HGNC=5026|UniProtKB=Q14541 Q14541 HNF4G PTHR24083:SF42 NUCLEAR HORMONE RECEPTOR HEPATOCYTE NUCLEAR FACTOR 4-GAMMA transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulator activity#GO:0140110;sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023;cis-regulatory region sequence-specific DNA binding#GO:0000987;molecular transducer activity#GO:0060089;nuclear receptor activity#GO:0004879;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837 positive regulation of RNA metabolic process#GO:0051254;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of DNA-templated transcription#GO:0006355;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;developmental process#GO:0032502;positive regulation of transcription by RNA polymerase II#GO:0045944 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 C4 zinc finger nuclear receptor#PC00169;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=34396|UniProtKB=P0CE71 P0CE71 OCM2 PTHR11653:SF4 PARVALBUMIN ALPHA ONCOMODULIN-2 metal ion binding#GO:0046872;cation binding#GO:0043169;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;calcium ion binding#GO:0005509 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 calmodulin-related#PC00061;calcium-binding protein#PC00060 HUMAN|HGNC=26176|UniProtKB=Q9H6H4 Q9H6H4 REEP4 PTHR12300:SF36 HVA22-LIKE PROTEINS RECEPTOR EXPRESSION-ENHANCING PROTEIN 4 tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;microtubule binding#GO:0008017;protein binding#GO:0005515 endomembrane system organization#GO:0010256;cellular component organization or biogenesis#GO:0071840;endoplasmic reticulum tubular network organization#GO:0071786;cellular process#GO:0009987;endoplasmic reticulum organization#GO:0007029;organelle organization#GO:0006996;cellular component organization#GO:0016043 endoplasmic reticulum#GO:0005783;cytoskeleton#GO:0005856;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;endoplasmic reticulum tubular network#GO:0071782;membrane#GO:0016020;microtubule cytoskeleton#GO:0015630;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;endomembrane system#GO:0012505;supramolecular complex#GO:0099080;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;microtubule#GO:0005874;cytoplasmic microtubule#GO:0005881;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175 membrane traffic protein#PC00150 HUMAN|HGNC=30123|UniProtKB=Q6PL18 Q6PL18 ATAD2 PTHR23069:SF4 AAA DOMAIN-CONTAINING ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 2 pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;histone binding#GO:0042393;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP-dependent activity#GO:0140657;chromatin binding#GO:0003682;hydrolase activity#GO:0016787;protein binding#GO:0005515;ATP hydrolysis activity#GO:0016887 positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;nucleosome organization#GO:0034728;regulation of biosynthetic process#GO:0009889;transcription by RNA polymerase II#GO:0006366;biological regulation#GO:0065007;biosynthetic process#GO:0009058;chromatin organization#GO:0006325;nucleobase-containing compound metabolic process#GO:0006139;positive regulation of cellular process#GO:0048522;macromolecule biosynthetic process#GO:0009059;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;epigenetic regulation of gene expression#GO:0040029;positive regulation of biosynthetic process#GO:0009891;protein-containing complex disassembly#GO:0032984;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;transcription initiation-coupled chromatin remodeling#GO:0045815;protein-containing complex organization#GO:0043933;protein-DNA complex organization#GO:0071824;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;positive regulation of macromolecule metabolic process#GO:0010604;gene expression#GO:0010467;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;transcription initiation at RNA polymerase II promoter#GO:0006367;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;cellular component disassembly#GO:0022411;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;chromatin remodeling#GO:0006338;DNA-templated transcription initiation#GO:0006352;regulation of biological process#GO:0050789;cellular component organization#GO:0016043 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=4526|UniProtKB=O95800 O95800 GPR75 PTHR24228:SF55 B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR G PROTEIN-COUPLED RECEPTOR 75-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;immune receptor activity#GO:0140375;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888;cytokine receptor activity#GO:0004896 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=4507|UniProtKB=O75899 O75899 GABBR2 PTHR10519:SF74 GABA-B RECEPTOR GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2 G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 cellular process#GO:0009987;regulation of biological process#GO:0050789;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;signaling#GO:0023052;cell communication#GO:0007154 signaling receptor complex#GO:0043235;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944 G-protein coupled receptor#PC00021 GABA-B receptor II signaling#P05731>GABA-B receptor#P05756 HUMAN|HGNC=24124|UniProtKB=O96019 O96019 ACTL6A PTHR11937:SF487 ACTIN ACTIN-LIKE PROTEIN 6A structural molecule activity#GO:0005198;chromatin binding#GO:0003682;structural constituent of cytoskeleton#GO:0005200;binding#GO:0005488 multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;developmental process#GO:0032502;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;chromatin organization#GO:0006325;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;nervous system development#GO:0007399;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;cellular process#GO:0009987;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;animal gross anatomical part developmental process#GO:0160108;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;chromatin remodeling#GO:0006338;cellular component organization#GO:0016043;regulation of biological process#GO:0050789 nucleus#GO:0005634;chromatin#GO:0000785;intracellular membraneless organelle#GO:0043232;NuA4 histone acetyltransferase complex#GO:0035267;protein-containing complex#GO:0032991;H4 histone acetyltransferase complex#GO:1902562;transferase complex#GO:1990234;histone acetyltransferase complex#GO:0000123;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;SWI/SNF superfamily-type complex#GO:0070603;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;SWI/SNF complex#GO:0016514;catalytic complex#GO:1902494;protein acetyltransferase complex#GO:0031248;ATPase complex#GO:1904949;membrane-bounded organelle#GO:0043227;acetyltransferase complex#GO:1902493;intracellular anatomical structure#GO:0005622 actin and actin related protein#PC00039 HUMAN|HGNC=13999|UniProtKB=P57071 P57071 PRDM15 PTHR16515:SF34 PR DOMAIN ZINC FINGER PROTEIN PR DOMAIN ZINC FINGER PROTEIN 15 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HUMAN|HGNC=17213|UniProtKB=Q9BWP8 Q9BWP8 COLEC11 PTHR24024:SF14 PULMONARY SURFACTANT-ASSOCIATED PROTEIN A COLLECTIN-11 signaling receptor activity#GO:0038023;pattern recognition receptor activity#GO:0038187;molecular transducer activity#GO:0060089 defense response to other organism#GO:0098542;positive regulation of response to stimulus#GO:0048584;response to other organism#GO:0051707;biological regulation#GO:0065007;positive regulation of immune system process#GO:0002684;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;defense response to symbiont#GO:0140546;immune response#GO:0006955;positive regulation of biological process#GO:0048518;complement activation#GO:0006956;activation of immune response#GO:0002253;innate immune response#GO:0045087;defense response#GO:0006952;response to external stimulus#GO:0009605;humoral immune response#GO:0006959;immune effector process#GO:0002252;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;regulation of immune system process#GO:0002682;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;regulation of biological process#GO:0050789;immune system process#GO:0002376;regulation of immune response#GO:0050776 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 structural protein#PC00211;surfactant#PC00212 HUMAN|HGNC=22831|UniProtKB=A6NCM1 A6NCM1 DRC11L PTHR14690:SF6 IQ MOTIF CONTAINING WITH AAA DOMAIN 1 DYNEIN REGULATORY COMPLEX SUBUNIT LIKE-11 HUMAN|HGNC=1748|UniProtKB=P12830 P12830 CDH1 PTHR24027:SF319 CADHERIN-23 CADHERIN-1 cell adhesion molecule binding#GO:0050839;binding#GO:0005488;beta-catenin binding#GO:0008013;protein binding#GO:0005515 anatomical structure development#GO:0048856;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;synapse organization#GO:0050808;cell adhesion#GO:0007155;synapse assembly#GO:0007416;cell junction organization#GO:0034330;cell motility#GO:0048870;cell junction assembly#GO:0034329;cellular component organization#GO:0016043;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;developmental process#GO:0032502;cellular component assembly#GO:0022607;multicellular organismal process#GO:0032501;cell migration#GO:0016477;nervous system development#GO:0007399;cellular component biogenesis#GO:0044085;cell-cell adhesion#GO:0098609;cellular process#GO:0009987 extrinsic component of plasma membrane#GO:0019897;extrinsic component of membrane#GO:0019898;cell junction#GO:0030054;membrane microdomain#GO:0098857;apical junction complex#GO:0043296;cytoplasm#GO:0005737;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;plasma membrane region#GO:0098590;cell periphery#GO:0071944;caveola#GO:0005901;membrane#GO:0016020;cell-cell junction#GO:0005911;anchoring junction#GO:0070161;intracellular anatomical structure#GO:0005622;plasma membrane raft#GO:0044853;cellular anatomical structure#GO:0110165;plasma membrane protein complex#GO:0098797;membrane raft#GO:0045121;membrane protein complex#GO:0098796 cadherin#PC00057;cell adhesion molecule#PC00069 Cadherin signaling pathway#P00012>Cadherin#P00471;Alzheimer disease-presenilin pathway#P00004>E-cadherin C-terminal fragment#P00117;CCKR signaling map#P06959>E-cadherin#G06981;Wnt signaling pathway#P00057>Cadherin#P01440;Alzheimer disease-presenilin pathway#P00004>E-cadherin intracellular fragment#P00168;Alzheimer disease-presenilin pathway#P00004>E-cadherin#P00118;Alzheimer disease-presenilin pathway#P00004>E-cadherin N-terminal fragment#P00165;CCKR signaling map#P06959>E-cadherin#P07171;Alzheimer disease-presenilin pathway#P00004>E-cadherin transmembrane fragment#P00139;CCKR signaling map#P06959>E-cadherin#G07274 HUMAN|HGNC=28958|UniProtKB=Q8N1F7 Q8N1F7 NUP93 PTHR11225:SF4 NUCLEAR PORE COMPLEX PROTEIN NUP93 NUCLEOPORIN NUP93 DEAD EYE PROTEIN NUCLEAR PORE COMPLEX PROTEIN NUP93 structural molecule activity#GO:0005198;structural constituent of nuclear pore#GO:0017056 mRNA transport#GO:0051028;establishment of RNA localization#GO:0051236;RNA transport#GO:0050658;protein localization to organelle#GO:0033365;RNA localization#GO:0006403;nucleobase-containing compound transport#GO:0015931;nuclear export#GO:0051168;nuclear transport#GO:0051169;nucleic acid transport#GO:0050657;localization#GO:0051179;nucleocytoplasmic transport#GO:0006913;biosynthetic process#GO:0009058;macromolecule biosynthetic process#GO:0009059;nitrogen compound transport#GO:0071705;protein localization to nucleus#GO:0034504;macromolecule localization#GO:0033036;import into nucleus#GO:0051170;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;macromolecule metabolic process#GO:0043170;poly(A)+ mRNA export from nucleus#GO:0016973;transport#GO:0006810;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;protein transport#GO:0015031;protein import into nucleus#GO:0006606;mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;gene expression#GO:0010467;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;intracellular protein transport#GO:0006886;metabolic process#GO:0008152 nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;nucleus#GO:0005634;organelle envelope#GO:0031967;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear pore#GO:0005643;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229 transporter#PC00227 HUMAN|HGNC=49603|UniProtKB=A0A0J9YX35 A0A0J9YX35 IGHV3-64D PTHR23266:SF372 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 3-23-RELATED binding#GO:0005488;antigen binding#GO:0003823 leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449;immunoglobulin mediated immune response#GO:0016064;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immune system process#GO:0002376;immune effector process#GO:0002252;response to stimulus#GO:0050896;adaptive immune response#GO:0002250;immune response#GO:0006955 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=22394|UniProtKB=Q6ZWB6 Q6ZWB6 KCTD8 PTHR14499:SF68 POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD8 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 regulation of biological process#GO:0050789;multicellular organismal process#GO:0032501;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;nervous system development#GO:0007399;animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502;regulation of G protein-coupled receptor signaling pathway#GO:0008277;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;multicellular organism development#GO:0007275;anatomical structure development#GO:0048856;system development#GO:0048731 presynaptic active zone#GO:0048786;cell junction#GO:0030054;signaling receptor complex#GO:0043235;synaptic membrane#GO:0097060;protein-containing complex#GO:0032991;plasma membrane region#GO:0098590;presynaptic membrane#GO:0042734;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;presynapse#GO:0098793;postsynaptic membrane#GO:0045211;cellular anatomical structure#GO:0110165;synapse#GO:0045202;presynaptic active zone membrane#GO:0048787;postsynapse#GO:0098794 scaffold/adaptor protein#PC00226 HUMAN|HGNC=2432|UniProtKB=P09603 P09603 CSF1 PTHR10058:SF0 MACROPHAGE COLONY STIMULATING FACTOR MACROPHAGE COLONY-STIMULATING FACTOR 1 molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677;cytokine activity#GO:0005125;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545 regulation of cellular process#GO:0050794;myeloid cell differentiation#GO:0030099;regulation of immune system process#GO:0002682;cell differentiation#GO:0030154;cell development#GO:0048468;regulation of developmental process#GO:0050793;leukocyte differentiation#GO:0002521;regulation of multicellular organismal development#GO:2000026;positive regulation of multicellular organismal process#GO:0051240;regulation of biological process#GO:0050789;anatomical structure development#GO:0048856;regulation of hemopoiesis#GO:1903706;osteoclast differentiation#GO:0030316;regulation of myeloid cell differentiation#GO:0045637;positive regulation of cell development#GO:0010720;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;hemopoiesis#GO:0030097;positive regulation of immune system process#GO:0002684;cellular process#GO:0009987;regulation of cell development#GO:0060284;positive regulation of myeloid cell differentiation#GO:0045639;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular developmental process#GO:0048869;positive regulation of cell differentiation#GO:0045597;regulation of cell differentiation#GO:0045595;developmental process#GO:0032502;positive regulation of developmental process#GO:0051094 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=13242|UniProtKB=Q9HCP6 Q9HCP6 HHATL PTHR13285:SF19 ACYLTRANSFERASE PROTEIN-CYSTEINE N-PALMITOYLTRANSFERASE HHAT-LIKE PROTEIN acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;palmitoyltransferase activity#GO:0016409;acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824 regulation of protein modification process#GO:0031399;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 acyltransferase#PC00042 HUMAN|HGNC=14086|UniProtKB=O60813 O60813 PRAMEF11 PTHR14224:SF112 SIMILAR TO PREFERENTIALLY EXPRESSED ANTIGEN IN MELANOMA-LIKE 3 PRAME FAMILY MEMBER 11-RELATED ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498 ubiquitin ligase complex#GO:0000151;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;transferase complex#GO:1990234;Cul2-RING ubiquitin ligase complex#GO:0031462;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cullin-RING ubiquitin ligase complex#GO:0031461;cytoplasm#GO:0005737 HUMAN|HGNC=3766|UniProtKB=P49771 P49771 FLT3LG PTHR11032:SF1 SL CYTOKINE FMS-RELATED TYROSINE KINASE 3 LIGAND kinase binding#GO:0019900;protein tyrosine kinase binding#GO:1990782;signaling receptor binding#GO:0005102;binding#GO:0005488;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;protein binding#GO:0005515;receptor tyrosine kinase binding#GO:0030971 positive regulation of cell population proliferation#GO:0008284;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789;regulation of cell population proliferation#GO:0042127;regulation of cellular process#GO:0050794;biological regulation#GO:0065007 cell surface#GO:0009986;cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207;cytokine#PC00083 HUMAN|HGNC=1103|UniProtKB=P25440 P25440 BRD2 PTHR22880:SF240 FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS BROMODOMAIN-CONTAINING PROTEIN 2 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;histone reader activity#GO:0140566;chromatin-protein adaptor activity#GO:0140463 regulation of biological process#GO:0050789;cellular component organization#GO:0016043;chromatin remodeling#GO:0006338;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;chromatin organization#GO:0006325;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of gene expression#GO:0010468;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=6427|UniProtKB=Q04695 Q04695 KRT17 PTHR23239:SF396 INTERMEDIATE FILAMENT KERATIN, TYPE I CYTOSKELETAL 17 structural molecule activity#GO:0005198 cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cell differentiation#GO:0030154;intermediate filament cytoskeleton organization#GO:0045104;intermediate filament-based process#GO:0045103;animal gross anatomical part developmental process#GO:0160108;keratinocyte differentiation#GO:0030216;intermediate filament organization#GO:0045109;tissue morphogenesis#GO:0048729;anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;organelle organization#GO:0006996;cellular process#GO:0009987;epithelium development#GO:0060429;epithelial cell differentiation#GO:0030855;epidermal cell differentiation#GO:0009913;tissue development#GO:0009888;cytoskeleton organization#GO:0007010;skin development#GO:0043588;epidermis development#GO:0008544;developmental process#GO:0032502;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;animal organ development#GO:0048513;morphogenesis of an epithelium#GO:0002009 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;intermediate filament#GO:0005882;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;organelle#GO:0043226;supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232 intermediate filament#PC00129 HUMAN|HGNC=3298|UniProtKB=O43432 O43432 EIF4G3 PTHR23253:SF23 EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 3 RNA binding#GO:0003723;translation initiation factor activity#GO:0003743;mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;translation factor activity#GO:0180051 primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;biosynthetic process#GO:0009058;metabolic process#GO:0008152;translation#GO:0006412;translational initiation#GO:0006413;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 translation initiation factor#PC00224 HUMAN|HGNC=14907|UniProtKB=A6NI15 A6NI15 MSGN1 PTHR20937:SF4 IP14615P MESOGENIN-1 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of nucleobase-containing compound metabolic process#GO:0019219;mesoderm formation#GO:0001707;tissue development#GO:0009888;multicellular organismal process#GO:0032501;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;embryo development#GO:0009790;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;embryonic morphogenesis#GO:0048598;multicellular organism development#GO:0007275;regulation of biosynthetic process#GO:0009889;mesoderm development#GO:0007498;anatomical structure formation involved in morphogenesis#GO:0048646;regulation of gene expression#GO:0010468;developmental process#GO:0032502;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;gastrulation#GO:0007369;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;mesoderm morphogenesis#GO:0048332;tissue morphogenesis#GO:0048729;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of RNA metabolic process#GO:0051252;animal gross anatomical part developmental process#GO:0160108;formation of primary germ layer#GO:0001704 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=29023|UniProtKB=Q6PFW1 Q6PFW1 PPIP5K1 PTHR12750:SF11 DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE INOSITOL HEXAKISPHOSPHATE AND DIPHOSPHOINOSITOL-PENTAKISPHOSPHATE KINASE 1 phosphotransferase activity, phosphate group as acceptor#GO:0016776;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 alcohol metabolic process#GO:0006066;metabolic process#GO:0008152;small molecule biosynthetic process#GO:0044283;organophosphate biosynthetic process#GO:0090407;phosphorus metabolic process#GO:0006793;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;alcohol biosynthetic process#GO:0046165;small molecule metabolic process#GO:0044281;biosynthetic process#GO:0009058 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 kinase#PC00137;nucleotide kinase#PC00172 HUMAN|HGNC=16856|UniProtKB=Q14674 Q14674 ESPL1 PTHR12792:SF3 EXTRA SPINDLE POLES 1-RELATED SEPARIN cysteine-type endopeptidase activity#GO:0004197;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234 cellular component organization or biogenesis#GO:0071840;meiotic nuclear division#GO:0140013;chromosome separation#GO:0051304;meiotic chromosome segregation#GO:0045132;meiotic cell cycle#GO:0051321;chromosome segregation#GO:0007059;organelle organization#GO:0006996;cellular process#GO:0009987;organelle fission#GO:0048285;nuclear division#GO:0000280;sexual reproduction#GO:0019953;reproductive process#GO:0022414;cell cycle#GO:0007049;nuclear chromosome segregation#GO:0098813;meiotic cell cycle process#GO:1903046;cellular component organization#GO:0016043;cell cycle process#GO:0022402 cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;spindle#GO:0005819;centrosome#GO:0005813;membraneless organelle#GO:0043228;nucleus#GO:0005634;microtubule cytoskeleton#GO:0015630;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;mitotic spindle#GO:0072686;cellular anatomical structure#GO:0110165;organelle#GO:0043226 cysteine protease#PC00081 HUMAN|HGNC=13004|UniProtKB=Q9UDV6 Q9UDV6 ZNF212 PTHR24390:SF49 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 212 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218 HUMAN|HGNC=20097|UniProtKB=Q96LQ0 Q96LQ0 PPP1R36 PTHR21055:SF3 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 36 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 36 phosphatase modulator#PC00184 HUMAN|HGNC=30314|UniProtKB=Q9UK61 Q9UK61 TASOR PTHR16207:SF1 SET DOMAIN-CONTAINING PROTEIN PROTEIN TASOR chromatin binding#GO:0003682;binding#GO:0005488 cellular component organization or biogenesis#GO:0071840;negative regulation of gene expression, epigenetic#GO:0045814;regulation of biosynthetic process#GO:0009889;intracellular protein localization#GO:0008104;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;chromatin organization#GO:0006325;macromolecule localization#GO:0033036;negative regulation of macromolecule biosynthetic process#GO:0010558;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;localization#GO:0051179;regulation of macromolecule metabolic process#GO:0060255;protein localization to organelle#GO:0033365;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789 nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;chromatin#GO:0000785;heterochromatin#GO:0000792;membraneless organelle#GO:0043228 HUMAN|HGNC=7728|UniProtKB=Q96PU5 Q96PU5 NEDD4L PTHR11254:SF443 HECT DOMAIN UBIQUITIN-PROTEIN LIGASE E3 UBIQUITIN-PROTEIN LIGASE NEDD4-LIKE aminoacyltransferase activity#GO:0016755;molecular function regulator activity#GO:0098772;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;ion channel inhibitor activity#GO:0008200;ion channel regulator activity#GO:0099106;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;molecular function inhibitor activity#GO:0140678;channel regulator activity#GO:0016247;transporter regulator activity#GO:0141108;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746 regulation of developmental process#GO:0050793;catabolic process#GO:0009056;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of dendrite development#GO:0050773;modification-dependent protein catabolic process#GO:0019941;regulation of biological process#GO:0050789;regulation of dendrite morphogenesis#GO:0048814;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;biological regulation#GO:0065007;regulation of neuron projection development#GO:0010975;cellular process#GO:0009987;ubiquitin-dependent protein catabolic process#GO:0006511;regulation of plasma membrane bounded cell projection organization#GO:0120035;macromolecule metabolic process#GO:0043170;regulation of anatomical structure morphogenesis#GO:0022603;metabolic process#GO:0008152;regulation of cell projection organization#GO:0031344;macromolecule catabolic process#GO:0009057 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=18729|UniProtKB=Q96QV6 Q96QV6 H2AC1 PTHR23430:SF137 HISTONE H2A HISTONE H2A TYPE 1-A structural molecule activity#GO:0005198 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;heterochromatin formation#GO:0031507;regulation of biological process#GO:0050789;cellular component assembly#GO:0022607;heterochromatin organization#GO:0070828;chromatin organization#GO:0006325;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;epigenetic regulation of gene expression#GO:0040029;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;negative regulation of gene expression, epigenetic#GO:0045814;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;protein-DNA complex#GO:0032993;intracellular membrane-bounded organelle#GO:0043231;nucleosome#GO:0000786;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694;nucleus#GO:0005634;chromatin#GO:0000785;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=7082|UniProtKB=P14209 P14209 CD99 PTHR15076:SF15 CD99/MIC2 PROTEIN RELATED CD99 ANTIGEN regulation of cell motility#GO:2000145;cell adhesion#GO:0007155;immune system process#GO:0002376;mononuclear cell migration#GO:0071674;regulation of leukocyte migration#GO:0002685;regulation of immune system process#GO:0002682;cell motility#GO:0048870;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;positive regulation of cell motility#GO:2000147;positive regulation of locomotion#GO:0040017;regulation of cell migration#GO:0030334;leukocyte migration#GO:0050900;biological regulation#GO:0065007;homotypic cell-cell adhesion#GO:0034109;regulation of locomotion#GO:0040012;cell migration#GO:0016477;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of cell migration#GO:0030335;positive regulation of immune system process#GO:0002684;lymphocyte migration#GO:0072676;cell-cell adhesion#GO:0098609 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=1119|UniProtKB=Q10589 Q10589 BST2 PTHR15190:SF1 BONE MARROW STROMAL ANTIGEN 2 BONE MARROW STROMAL ANTIGEN 2 endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772;enzyme inhibitor activity#GO:0004857;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;peptidase regulator activity#GO:0061134 immune response#GO:0006955;defense response to symbiont#GO:0140546;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;defense response to virus#GO:0051607;response to other organism#GO:0051707;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;defense response to other organism#GO:0098542;response to stimulus#GO:0050896;immune system process#GO:0002376;defense response#GO:0006952;response to external stimulus#GO:0009605;response to virus#GO:0009615;innate immune response#GO:0045087 membrane#GO:0016020;apical plasma membrane#GO:0016324;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;plasma membrane region#GO:0098590;plasma membrane#GO:0005886;apical part of cell#GO:0045177 HUMAN|HGNC=30269|UniProtKB=Q96E17 Q96E17 RAB3C PTHR47980:SF15 LD44762P RAS-RELATED PROTEIN RAB-3C binding#GO:0005488;myosin binding#GO:0017022;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515 transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;secretion#GO:0046903;secretion by cell#GO:0032940;exocytosis#GO:0006887;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;export from cell#GO:0140352 presynapse#GO:0098793;cell periphery#GO:0071944;membrane#GO:0016020;secretory vesicle#GO:0099503;plasma membrane#GO:0005886;cytoplasm#GO:0005737;transport vesicle#GO:0030133;endomembrane system#GO:0012505;cell junction#GO:0030054;vesicle#GO:0031982;synaptic vesicle#GO:0008021;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;synapse#GO:0045202;intracellular organelle#GO:0043229;endosome#GO:0005768;exocytic vesicle#GO:0070382;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410 Synaptic vesicle trafficking#P05734>Rab3A#P05780 HUMAN|HGNC=23360|UniProtKB=Q8N163 Q8N163 CCAR2 PTHR14304:SF12 CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN CELL CYCLE AND APOPTOSIS REGULATOR PROTEIN 2 transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=5013|UniProtKB=P09601 P09601 HMOX1 PTHR10720:SF1 HEME OXYGENASE HEME OXYGENASE 1 monooxygenase activity#GO:0004497;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;heme binding#GO:0020037;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen#GO:0016712;oxidoreductase activity#GO:0016491;binding#GO:0005488;tetrapyrrole binding#GO:0046906 response to oxidative stress#GO:0006979;metabolic process#GO:0008152;tetrapyrrole metabolic process#GO:0033013;porphyrin-containing compound metabolic process#GO:0006778;response to stimulus#GO:0050896;catabolic process#GO:0009056;heme metabolic process#GO:0042168;pigment metabolic process#GO:0042440;response to stress#GO:0006950;cellular process#GO:0009987 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;plasma membrane#GO:0005886 oxidoreductase#PC00176;oxygenase#PC00177 HUMAN|HGNC=23181|UniProtKB=O43374 O43374 RASA4 PTHR10194:SF4 RAS GTPASE-ACTIVATING PROTEINS RAS GTPASE-ACTIVATING PROTEIN 4-RELATED GTPase-activating protein#PC00257 FGF signaling pathway#P00021>RasGAP#P00646;PDGF signaling pathway#P00047>RasGAP#P01152;EGF receptor signaling pathway#P00018>GAP#P00546 HUMAN|HGNC=15211|UniProtKB=Q8NGF0 Q8NGF0 OR52B6 PTHR26450:SF32 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 52B6 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=16822|UniProtKB=P78312 P78312 FAM193A PTHR15109:SF2 AGAP004327-PA PROTEIN FAM193A HUMAN|HGNC=3315|UniProtKB=P26378 P26378 ELAVL4 PTHR10352:SF9 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G ELAV-LIKE PROTEIN 4 regulation of mRNA metabolic process#GO:1903311;multicellular organism development#GO:0007275;negative regulation of RNA metabolic process#GO:0051253;positive regulation of macromolecule metabolic process#GO:0010604;nervous system development#GO:0007399;mRNA stabilization#GO:0048255;positive regulation of biological process#GO:0048518;RNA stabilization#GO:0043489;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of biological quality#GO:0065008;animal gross anatomical part developmental process#GO:0160108;regulation of mRNA stability#GO:0043488;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;positive regulation of gene expression#GO:0010628;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;negative regulation of RNA catabolic process#GO:1902369;developmental process#GO:0032502;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;anatomical structure development#GO:0048856;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;negative regulation of catabolic process#GO:0009895;regulation of RNA stability#GO:0043487;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255 intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;perikaryon#GO:0043204;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cell body#GO:0044297;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;somatodendritic compartment#GO:0036477;neuronal cell body#GO:0043025;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 translation factor#PC00223;translation initiation factor#PC00224;translational protein#PC00263 HUMAN|HGNC=20648|UniProtKB=Q96HQ0 Q96HQ0 ZNF419 PTHR24377:SF1002 IP01015P-RELATED ZINC FINGER PROTEIN 419 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=16347|UniProtKB=Q6IS24 Q6IS24 GALNT17 PTHR11675:SF38 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 17 catalytic activity, acting on a protein#GO:0140096;UDP-glycosyltransferase activity#GO:0008194;acetylgalactosaminyltransferase activity#GO:0008376;glycosyltransferase activity#GO:0016757;hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;catalytic activity#GO:0003824;polypeptide N-acetylgalactosaminyltransferase activity#GO:0004653 protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein O-linked glycosylation#GO:0006493;carbohydrate derivative metabolic process#GO:1901135 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 transferase#PC00220;glycosyltransferase#PC00111 HUMAN|HGNC=53649|UniProtKB=A0A1W2PS18 A0A1W2PS18 PMIS2 PTHR14768:SF5 UPF0338 PROTEIN TRANSMEMBRANE PROTEIN PMIS2 intracellular organelle#GO:0043229;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=21329|UniProtKB=Q86UN2 Q86UN2 RTN4RL1 PTHR24373:SF274 SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN RETICULON-4 RECEPTOR-LIKE 1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=20956|UniProtKB=O75167 O75167 PHACTR2 PTHR12751:SF5 PHOSPHATASE AND ACTIN REGULATOR PHACTR PHOSPHATASE AND ACTIN REGULATOR 2 binding#GO:0005488;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515 actin filament-based process#GO:0030029;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;cellular component organization or biogenesis#GO:0071840 phosphatase modulator#PC00184 HUMAN|HGNC=4443|UniProtKB=P40197 P40197 GP5 PTHR45617:SF38 LEUCINE RICH REPEAT FAMILY PROTEIN PLATELET GLYCOPROTEIN V regulation of platelet activation#GO:0010543;blood coagulation, fibrin clot formation#GO:0072378;protein metabolic process#GO:0019538;protein activation cascade#GO:0072376;wound healing#GO:0042060;regulation of biological quality#GO:0065008;hemostasis#GO:0007599;primary metabolic process#GO:0044238;regulation of cell activation#GO:0050865;positive regulation of multicellular organismal process#GO:0051240;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of body fluid levels#GO:0050878;response to stimulus#GO:0050896;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;blood coagulation#GO:0007596;response to stress#GO:0006950;response to wounding#GO:0009611;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;coagulation#GO:0050817;positive regulation of cellular process#GO:0048522;multicellular organismal process#GO:0032501;protein maturation#GO:0051604;gene expression#GO:0010467;regulation of multicellular organismal process#GO:0051239;positive regulation of cell activation#GO:0050867;biosynthetic process#GO:0009058;biological regulation#GO:0065007 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;signaling receptor complex#GO:0043235 scaffold/adaptor protein#PC00226 Blood coagulation#P00011>GP V#P00420 HUMAN|Ensembl=ENSG00000284580.3|UniProtKB=A0A7I2V4Q5 A0A7I2V4Q5 LOC112267881 PTHR11738:SF189 MHC CLASS I NK CELL RECEPTOR IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN-RELATED transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;immune receptor activity#GO:0140375;signaling receptor activity#GO:0038023 signaling#GO:0023052;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;immune response-regulating signaling pathway#GO:0002764;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;regulation of immune response#GO:0050776;cell surface receptor signaling pathway#GO:0007166;regulation of response to stimulus#GO:0048583 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=9907|UniProtKB=P29558 P29558 RBMS1 PTHR24012:SF702 RNA BINDING PROTEIN RNA-BINDING MOTIF, SINGLE-STRANDED-INTERACTING PROTEIN 1 nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 protein-containing complex#GO:0032991;ribonucleoprotein complex#GO:1990904 RNA metabolism protein#PC00031 HUMAN|HGNC=21578|UniProtKB=Q7Z419 Q7Z419 RNF144B PTHR11685:SF104 RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING E3 UBIQUITIN-PROTEIN LIGASE RNF144B catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;enzyme binding#GO:0019899;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;binding#GO:0005488;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;protein binding#GO:0005515 modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238;catabolic process#GO:0009056;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ubiquitin ligase complex#GO:0000151;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;organelle envelope#GO:0031967;organelle membrane#GO:0031090;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;membrane#GO:0016020 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=30839|UniProtKB=Q7Z3Z0 Q7Z3Z0 KRT25 PTHR23239:SF160 INTERMEDIATE FILAMENT KERATIN, TYPE I CYTOSKELETAL 25 structural molecule activity#GO:0005198 intermediate filament-based process#GO:0045103;animal gross anatomical part developmental process#GO:0160108;intermediate filament organization#GO:0045109;tissue morphogenesis#GO:0048729;anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cell differentiation#GO:0030154;intermediate filament cytoskeleton organization#GO:0045104;epidermis development#GO:0008544;developmental process#GO:0032502;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;animal organ development#GO:0048513;morphogenesis of an epithelium#GO:0002009;organelle organization#GO:0006996;cellular process#GO:0009987;epithelium development#GO:0060429;tissue development#GO:0009888;multicellular organismal process#GO:0032501;epithelial cell differentiation#GO:0030855;cytoskeleton organization#GO:0007010;skin development#GO:0043588 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intermediate filament#GO:0005882;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;intracellular membraneless organelle#GO:0043232;supramolecular complex#GO:0099080;organelle#GO:0043226;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165 intermediate filament#PC00129 HUMAN|HGNC=8571|UniProtKB=Q9UNF0 Q9UNF0 PACSIN2 PTHR23065:SF14 PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1 PROTEIN KINASE C AND CASEIN KINASE SUBSTRATE IN NEURONS PROTEIN 2 lipid binding#GO:0008289;binding#GO:0005488;phospholipid binding#GO:0005543 regulation of endocytosis#GO:0030100;cellular component organization or biogenesis#GO:0071840;plasma membrane organization#GO:0007009;regulation of localization#GO:0032879;regulation of transport#GO:0051049;organelle organization#GO:0006996;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;cellular process#GO:0009987;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;membrane organization#GO:0061024;cytoskeleton organization#GO:0007010;endomembrane system organization#GO:0010256 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular vesicle#GO:0097708;membrane#GO:0016020;vesicle#GO:0031982;cell periphery#GO:0071944 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=25104|UniProtKB=Q2VPB7 Q2VPB7 AP5B1 PTHR34033:SF1 AP-5 COMPLEX SUBUNIT BETA-1 AP-5 COMPLEX SUBUNIT BETA-1 cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;transport#GO:0006810;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;endosomal transport#GO:0016197 coated membrane#GO:0048475;membrane coat#GO:0030117;AP-type membrane coat adaptor complex#GO:0030119;intracellular anatomical structure#GO:0005622;membrane protein complex#GO:0098796;membrane#GO:0016020;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737 HUMAN|HGNC=26494|UniProtKB=Q96MN5 Q96MN5 TCEANC2 PTHR11477:SF14 TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN TRANSCRIPTION ELONGATION FACTOR A N-TERMINAL AND CENTRAL DOMAIN-CONTAINING PROTEIN 2 transcription elongation factor activity#GO:0003711;transcription regulator activity#GO:0140110 transcription elongation by RNA polymerase II#GO:0006368;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;DNA-templated transcription elongation#GO:0006354;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;transcription by RNA polymerase II#GO:0006366;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 general transcription factor#PC00259;RNA metabolism protein#PC00031 HUMAN|HGNC=30614|UniProtKB=Q7Z5L4 Q7Z5L4 SPATA19 PTHR36468:SF1 SPERMATOGENESIS-ASSOCIATED PROTEIN 19, MITOCHONDRIAL SPERMATOGENESIS-ASSOCIATED PROTEIN 19, MITOCHONDRIAL mitochondrion organization#GO:0007005;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996 plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;sperm flagellum#GO:0036126;cellular anatomical structure#GO:0110165;organelle#GO:0043226;motile cilium#GO:0031514;membrane-bounded organelle#GO:0043227;9+2 motile cilium#GO:0097729;cilium#GO:0005929 HUMAN|HGNC=18533|UniProtKB=Q86UV5 Q86UV5 USP48 PTHR24006:SF722 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 48 hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity, acting on a protein#GO:0140096;cysteine-type peptidase activity#GO:0008234;cysteine-type deubiquitinase activity#GO:0004843;catalytic activity#GO:0003824 regulation of protein stability#GO:0031647;biological regulation#GO:0065007;regulation of biological quality#GO:0065008 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cytosol#GO:0005829;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 protease#PC00190;cysteine protease#PC00081 HUMAN|HGNC=14404|UniProtKB=Q8TBG4 Q8TBG4 ETNPPL PTHR45688:SF1 FAMILY NOT NAMED ETHANOLAMINE-PHOSPHATE PHOSPHO-LYASE lyase activity#GO:0016829;carbon-oxygen lyase activity#GO:0016835;catalytic activity#GO:0003824 HUMAN|HGNC=19901|UniProtKB=Q5VZM2 Q5VZM2 RRAGB PTHR11259:SF4 RAS-RELATED GTP BINDING RAG/GTR YEAST RAS-RELATED GTP-BINDING PROTEIN B nucleoside phosphate binding#GO:1901265;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;guanyl nucleotide binding#GO:0019001;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;ion binding#GO:0043167;GTPase activity#GO:0003924;anion binding#GO:0043168;small molecule binding#GO:0036094;hydrolase activity#GO:0016787;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111 cellular process#GO:0009987;regulation of TOR signaling#GO:0032006;positive regulation of biological process#GO:0048518;response to stress#GO:0006950;regulation of biological process#GO:0050789;regulation of autophagy#GO:0010506;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;response to stimulus#GO:0050896;regulation of signaling#GO:0023051;cellular response to stress#GO:0033554;regulation of intracellular signal transduction#GO:1902531;positive regulation of signaling#GO:0023056;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;positive regulation of TORC1 signaling#GO:1904263;response to nutrient levels#GO:0031667;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of response to stimulus#GO:0048584;regulation of response to stimulus#GO:0048583;cellular response to nutrient levels#GO:0031669;positive regulation of intracellular signal transduction#GO:1902533;negative regulation of cellular process#GO:0048523;cellular response to starvation#GO:0009267;regulation of catabolic process#GO:0009894;negative regulation of autophagy#GO:0010507;regulation of TORC1 signaling#GO:1903432;cellular response to stimulus#GO:0051716;response to starvation#GO:0042594;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;negative regulation of catabolic process#GO:0009895;positive regulation of TOR signaling#GO:0032008 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;lytic vacuole#GO:0000323;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;vacuole#GO:0005773;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;lysosome#GO:0005764 small GTPase#PC00208 HUMAN|HGNC=6806|UniProtKB=P43361 P43361 MAGEA8 PTHR11736:SF65 MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN MELANOMA-ASSOCIATED ANTIGEN 8 binding#GO:0005488;enzyme binding#GO:0019899;protein binding#GO:0005515;histone deacetylase binding#GO:0042826 regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 scaffold/adaptor protein#PC00226 HUMAN|HGNC=2710|UniProtKB=P32321 P32321 DCTD PTHR11086:SF23 DEOXYCYTIDYLATE DEAMINASE-RELATED DEOXYCYTIDYLATE DEAMINASE hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;deaminase activity#GO:0019239;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity#GO:0016787;catalytic activity#GO:0003824 nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;organophosphate metabolic process#GO:0019637;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;pyrimidine-containing compound metabolic process#GO:0072527;nucleoside phosphate biosynthetic process#GO:1901293;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;small molecule metabolic process#GO:0044281;nucleoside monophosphate metabolic process#GO:0009123;nucleoside phosphate metabolic process#GO:0006753;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;nucleotide metabolic process#GO:0009117;organophosphate biosynthetic process#GO:0090407;nucleotide biosynthetic process#GO:0009165;nucleoside monophosphate biosynthetic process#GO:0009124 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 deaminase#PC00088;hydrolase#PC00121 HUMAN|HGNC=28910|UniProtKB=Q96HB5 Q96HB5 CCDC120 PTHR16093:SF5 COILED-COIL DOMAIN-CONTAINING PROTEIN 120 FAMILY MEMBER COILED-COIL DOMAIN-CONTAINING PROTEIN 120 HUMAN|HGNC=7211|UniProtKB=P29372 P29372 MPG PTHR10429:SF0 DNA-3-METHYLADENINE GLYCOSYLASE DNA-3-METHYLADENINE GLYCOSYLASE catalytic activity, acting on DNA#GO:0140097;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;DNA N-glycosylase activity#GO:0019104 nucleobase-containing compound metabolic process#GO:0006139;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;nucleic acid metabolic process#GO:0090304;base-excision repair#GO:0006284;primary metabolic process#GO:0044238;response to stress#GO:0006950;macromolecule metabolic process#GO:0043170;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281 DNA glycosylase#PC00010;DNA metabolism protein#PC00009 HUMAN|HGNC=8182|UniProtKB=Q15619 Q15619 OR1C1 PTHR48001:SF114 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 1C1 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=2976|UniProtKB=P26358 P26358 DNMT1 PTHR10629:SF61 CYTOSINE-SPECIFIC METHYLTRANSFERASE DNA (CYTOSINE-5)-METHYLTRANSFERASE 1 catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on DNA#GO:0140097;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA binding#GO:0003677 negative regulation of biosynthetic process#GO:0009890;chromatin organization#GO:0006325;biological regulation#GO:0065007;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of gene expression, epigenetic#GO:0045814;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA metabolism protein#PC00009;DNA methyltransferase#PC00013 HUMAN|HGNC=24191|UniProtKB=Q6UVW9 Q6UVW9 CLEC2A PTHR45710:SF40 C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN 180 C-TYPE LECTIN DOMAIN FAMILY 2 MEMBER A receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677 regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166;positive regulation of immune response#GO:0050778;T cell receptor signaling pathway#GO:0050852;immune response-activating signaling pathway#GO:0002757;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;activation of immune response#GO:0002253;positive regulation of immune system process#GO:0002684;immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;antigen receptor-mediated signaling pathway#GO:0050851;lymphocyte activation#GO:0046649;positive regulation of response to stimulus#GO:0048584;cell activation#GO:0001775;regulation of immune response#GO:0050776;immune system process#GO:0002376;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;immune response-regulating signaling pathway#GO:0002764;regulation of biological process#GO:0050789;T cell activation#GO:0042110;leukocyte activation#GO:0045321;immune response-activating cell surface receptor signaling pathway#GO:0002429;signaling#GO:0023052;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;response to stimulus#GO:0050896 plasma membrane#GO:0005886;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020 defense/immunity protein#PC00090 HUMAN|HGNC=26346|UniProtKB=Q96LL3 Q96LL3 FIMP PTHR38648:SF1 RIKEN CDNA 4930451I11 GENE FERTILIZATION-INFLUENCING MEMBRANE PROTEIN single fertilization#GO:0007338;fusion of sperm to egg plasma membrane involved in single fertilization#GO:0007342;cellular process#GO:0009987;reproductive process#GO:0022414;cellular process involved in reproduction in multicellular organism#GO:0022412;fertilization#GO:0009566;sexual reproduction#GO:0019953;multicellular organismal reproductive process#GO:0048609 HUMAN|HGNC=14859|UniProtKB=Q9HA47 Q9HA47 UCK1 PTHR10285:SF66 URIDINE KINASE URIDINE-CYTIDINE KINASE 1 phosphotransferase activity, alcohol group as acceptor#GO:0016773;nucleoside kinase activity#GO:0019206;transferase activity#GO:0016740;nucleobase-containing compound kinase activity#GO:0019205;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 nucleotide kinase#PC00172;kinase#PC00137 Salvage pyrimidine ribonucleotides#P02775>Uridine kinase#P03150;Salvage pyrimidine ribonucleotides#P02775>Cytidine kinase#P03149;Salvage pyrimidine ribonucleotides#P02775>CDP kinase#P03156 HUMAN|HGNC=3311|UniProtKB=P30740 P30740 SERPINB1 PTHR11461:SF180 SERINE PROTEASE INHIBITOR, SERPIN LEUKOCYTE ELASTASE INHIBITOR molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866;enzyme inhibitor activity#GO:0004857;serine-type endopeptidase inhibitor activity#GO:0004867;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;peptidase regulator activity#GO:0061134;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414 regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;negative regulation of multicellular organismal process#GO:0051241;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of multicellular organismal process#GO:0051239;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cytokine production#GO:0001817;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HUMAN|HGNC=1050|UniProtKB=P55957 P55957 BID PTHR35447:SF1 BH3-INTERACTING DOMAIN DEATH AGONIST BH3-INTERACTING DOMAIN DEATH AGONIST regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of extrinsic apoptotic signaling pathway#GO:2001238;positive regulation of cellular process#GO:0048522;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of apoptotic signaling pathway#GO:2001233;programmed cell death#GO:0012501;positive regulation of signal transduction#GO:0009967;regulation of extrinsic apoptotic signaling pathway#GO:2001236;cell death#GO:0008219;regulation of intrinsic apoptotic signaling pathway#GO:2001242;regulation of mitochondrion organization#GO:0010821;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;positive regulation of apoptotic signaling pathway#GO:2001235;regulation of apoptotic process#GO:0042981;positive regulation of apoptotic process#GO:0043065;cellular component organization or biogenesis#GO:0071840;organelle organization#GO:0006996;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;apoptotic mitochondrial changes#GO:0008637;mitochondrion organization#GO:0007005;regulation of release of cytochrome c from mitochondria#GO:0090199;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;positive regulation of cellular component organization#GO:0051130;positive regulation of signaling#GO:0023056;positive regulation of organelle organization#GO:0010638;cellular component organization#GO:0016043;regulation of programmed cell death#GO:0043067;apoptotic process#GO:0006915;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;positive regulation of programmed cell death#GO:0043068;regulation of cellular component organization#GO:0051128 mitochondrion#GO:0005739;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=53642|UniProtKB=A0A1B0GWB2 A0A1B0GWB2 PRRT1B PTHR14948:SF18 NG5 PROLINE RICH TRANSMEMBRANE PROTEIN 1B membrane#GO:0016020;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=24295|UniProtKB=A0FGR9 A0FGR9 ESYT3 PTHR45761:SF4 EXTENDED SYNAPTOTAGMIN-LIKE PROTEIN 2, ISOFORM C EXTENDED SYNAPTOTAGMIN-3 phosphatidylcholine binding#GO:0031210;phospholipid binding#GO:0005543;phosphatidylinositol binding#GO:0035091;metal ion binding#GO:0046872;cation binding#GO:0043169;lipid binding#GO:0008289;binding#GO:0005488;small molecule binding#GO:0036094;anion binding#GO:0043168;ion binding#GO:0043167;calcium ion binding#GO:0005509 membrane#GO:0016020;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090 membrane traffic protein#PC00150;membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=3219|UniProtKB=O95967 O95967 EFEMP2 PTHR24034:SF96 EGF-LIKE DOMAIN-CONTAINING PROTEIN EGF-CONTAINING FIBULIN-LIKE EXTRACELLULAR MATRIX PROTEIN 2 extracellular structure organization#GO:0043062;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;supramolecular fiber organization#GO:0097435;external encapsulating structure organization#GO:0045229;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;extracellular matrix assembly#GO:0085029;cellular component assembly#GO:0022607 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012 extracellular matrix structural protein#PC00103;extracellular matrix protein#PC00102 HUMAN|HGNC=4519|UniProtKB=Q15743 Q15743 GPR68 PTHR24234:SF5 LYSOPHOSPHATIDIC ACID RECEPTOR 5/SPHINGOSYLPHOSPHORYLCHOLINE RECEPTOR G PROTEIN-COUPLED RECEPTOR 68 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to abiotic stimulus#GO:0009628;cellular response to environmental stimulus#GO:0104004;cellular response to abiotic stimulus#GO:0071214;response to stimulus#GO:0050896 G-protein coupled receptor#PC00021 HUMAN|HGNC=2955|UniProtKB=O96015 O96015 DNAL4 PTHR11886:SF2 DYNEIN LIGHT CHAIN DYNEIN AXONEMAL LIGHT CHAIN 4 microtubule or microtubule-binding cytoskeletal protein#PC00157 Huntington disease#P00029>Dynein complex#P00774 HUMAN|HGNC=1082|UniProtKB=Q12981 Q12981 BNIP1 PTHR12825:SF0 BNIP1-RELATED VESICLE TRANSPORT PROTEIN SEC20 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;SNAP receptor activity#GO:0005484 localization#GO:0051179;establishment of localization#GO:0051234;vesicle-mediated transport#GO:0016192;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;Golgi vesicle transport#GO:0048193;cellular process#GO:0009987;transport#GO:0006810 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane protein complex#GO:0098796;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;SNARE complex#GO:0031201 HUMAN|HGNC=25073|UniProtKB=Q96E39 Q96E39 RBMXL1 PTHR48034:SF20 TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED RNA BINDING MOTIF PROTEIN, X-LINKED-LIKE-1 RNA binding#GO:0003723;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488 nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA splicing, via spliceosome#GO:0000398;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467 organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;spliceosomal complex#GO:0005681;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031 HUMAN|HGNC=8138|UniProtKB=Q9UBC0 Q9UBC0 ONECUT1 PTHR14057:SF9 TRANSCRIPTION FACTOR ONECUT HEPATOCYTE NUCLEAR FACTOR 6 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 HUMAN|HGNC=53845|UniProtKB=A6NLC8 A6NLC8 TAF11L2 PTHR13218:SF15 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11-RELATED TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 11 LIKE PROTEIN 2-RELATED macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;transcription initiation at RNA polymerase II promoter#GO:0006367;cellular component biogenesis#GO:0044085;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;protein-DNA complex assembly#GO:0065004;cellular component assembly#GO:0022607;gene expression#GO:0010467;transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;protein-containing complex organization#GO:0043933;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;protein-DNA complex organization#GO:0071824;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;RNA polymerase II preinitiation complex assembly#GO:0051123;DNA-templated transcription initiation#GO:0006352;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070 transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;RNA polymerase II, holoenzyme#GO:0016591;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;transcription regulator complex#GO:0005667;membrane-enclosed lumen#GO:0031974;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;transcription factor TFIID complex#GO:0005669 general transcription factor#PC00259;RNA metabolism protein#PC00031 Transcription regulation by bZIP transcription factor#P00055>TBP-associated factors#P01385;General transcription regulation#P00023>TBP-associated factors#P00658 HUMAN|HGNC=717|UniProtKB=P51689 P51689 ARSD PTHR42693:SF5 ARYLSULFATASE FAMILY MEMBER ARYLSULFATASE D hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788 hydrolase#PC00121 HUMAN|HGNC=25669|UniProtKB=Q9HAH1 Q9HAH1 ZNF556 PTHR24381:SF160 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 556 double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=37173|UniProtKB=Q6ZRP0 Q6ZRP0 PRR23C PTHR31813:SF6 PROLINE-RICH PROTEIN 23B PROLINE-RICH PROTEIN 23C HUMAN|HGNC=12591|UniProtKB=P06132 P06132 UROD PTHR21091:SF169 METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED UROPORPHYRINOGEN DECARBOXYLASE lyase activity#GO:0016829;carbon-carbon lyase activity#GO:0016830;carboxy-lyase activity#GO:0016831;catalytic activity#GO:0003824 tetrapyrrole metabolic process#GO:0033013;metabolic process#GO:0008152;porphyrin-containing compound metabolic process#GO:0006778;pigment biosynthetic process#GO:0046148;porphyrin-containing compound biosynthetic process#GO:0006779;pigment metabolic process#GO:0042440;heme biosynthetic process#GO:0006783;cellular process#GO:0009987;tetrapyrrole biosynthetic process#GO:0033014;heme metabolic process#GO:0042168;biosynthetic process#GO:0009058 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 methyltransferase#PC00155 Heme biosynthesis#P02746>Uroporphyrinogen decarboxylase#P02975 HUMAN|HGNC=2220|UniProtKB=Q9Y6Z7 Q9Y6Z7 COLEC10 PTHR24024:SF20 PULMONARY SURFACTANT-ASSOCIATED PROTEIN A COLLECTIN-10 molecular transducer activity#GO:0060089;pattern recognition receptor activity#GO:0038187;signaling receptor activity#GO:0038023 innate immune response#GO:0045087;defense response#GO:0006952;response to external stimulus#GO:0009605;humoral immune response#GO:0006959;regulation of response to stimulus#GO:0048583;immune effector process#GO:0002252;positive regulation of immune response#GO:0050778;defense response to other organism#GO:0098542;positive regulation of response to stimulus#GO:0048584;response to other organism#GO:0051707;biological regulation#GO:0065007;response to stress#GO:0006950;positive regulation of immune system process#GO:0002684;response to biotic stimulus#GO:0009607;complement activation#GO:0006956;positive regulation of biological process#GO:0048518;defense response to symbiont#GO:0140546;activation of immune response#GO:0002253;immune response#GO:0006955;immune system process#GO:0002376;regulation of immune response#GO:0050776;regulation of immune system process#GO:0002682;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;regulation of biological process#GO:0050789 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 structural protein#PC00211;surfactant#PC00212 HUMAN|HGNC=32207|UniProtKB=Q6ZN17 Q6ZN17 LIN28B PTHR46109:SF3 PROTEIN LIN-28 PROTEIN LIN-28 HOMOLOG B RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729 nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;RNA processing#GO:0006396;gene expression#GO:0010467;miRNA processing#GO:0035196;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulatory ncRNA-mediated gene silencing#GO:0031047;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulatory ncRNA processing#GO:0070918;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;pre-miRNA processing#GO:0031054;regulation of macromolecule metabolic process#GO:0060255 nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HUMAN|HGNC=9029|UniProtKB=O15496 O15496 PLA2G10 PTHR11716:SF4 PHOSPHOLIPASE A2 FAMILY MEMBER GROUP 10 SECRETORY PHOSPHOLIPASE A2 calcium ion binding#GO:0005509;binding#GO:0005488;lipid binding#GO:0008289;metal ion binding#GO:0046872;phospholipase activity#GO:0120569;glycerophospholipase activity#GO:0004620;A2-type glycerophospholipase activity#GO:0004623;carboxylic ester hydrolase activity#GO:0052689;ion binding#GO:0043167;lipase activity#GO:0016298;small molecule binding#GO:0036094;cation binding#GO:0043169;hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phospholipid binding#GO:0005543;catalytic activity#GO:0003824 lipid metabolic process#GO:0006629;metabolic process#GO:0008152;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phospholipid metabolic process#GO:0006644;glycerophospholipid metabolic process#GO:0006650;phosphatidylcholine metabolic process#GO:0046470;glycerolipid metabolic process#GO:0046486;phosphatidylglycerol metabolic process#GO:0046471 phospholipase#PC00186 HUMAN|HGNC=16119|UniProtKB=Q9NUG6 Q9NUG6 PDRG1 PTHR21162:SF0 P53 AND DNA DAMAGE-REGULATED PROTEIN P53 AND DNA DAMAGE-REGULATED PROTEIN 1 HUMAN|HGNC=29293|UniProtKB=Q9P227 Q9P227 ARHGAP23 PTHR23175:SF5 PDZ DOMAIN-CONTAINING PROTEIN RHO GTPASE-ACTIVATING PROTEIN 23 enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096 HUMAN|HGNC=15261|UniProtKB=Q8N127 Q8N127 OR5AS1 PTHR26452:SF704 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5AS1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606;sensory perception#GO:0007600;nervous system process#GO:0050877 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=26618|UniProtKB=P0C025 P0C025 NUDT17 PTHR42904:SF1 NUDIX HYDROLASE, NUDC SUBFAMILY M7GPPPN-MRNA HYDROLASE NUDT17 hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787 organophosphate metabolic process#GO:0019637;NAD+ metabolic process#GO:0019674;nucleobase-containing compound catabolic process#GO:0034655;NADP+ metabolic process#GO:0006739;nicotinamide nucleotide metabolic process#GO:0046496;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;nucleotide catabolic process#GO:0009166;purine-containing compound catabolic process#GO:0072523;nucleobase-containing small molecule metabolic process#GO:0055086;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;purine nucleotide metabolic process#GO:0006163;pyridine-containing compound catabolic process#GO:0072526;purine-containing compound metabolic process#GO:0072521;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;nucleoside phosphate catabolic process#GO:1901292;pyridine nucleotide catabolic process#GO:0019364;nucleoside phosphate metabolic process#GO:0006753;purine nucleotide catabolic process#GO:0006195;pyridine-containing compound metabolic process#GO:0072524;nucleotide metabolic process#GO:0009117;organophosphate catabolic process#GO:0046434 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;microbody#GO:0042579;peroxisome#GO:0005777;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 hydrolase#PC00121 HUMAN|HGNC=33785|UniProtKB=Q69YZ2 Q69YZ2 TMEM200B PTHR31815:SF3 AGAP005329-PA TRANSMEMBRANE PROTEIN 200B HUMAN|HGNC=9009|UniProtKB=Q13563 Q13563 PKD2 PTHR10877:SF114 POLYCYSTIN FAMILY MEMBER POLYCYSTIN-2 binding#GO:0005488;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;calcium ion binding#GO:0005509;metal ion binding#GO:0046872;voltage-gated channel activity#GO:0022832;protein binding#GO:0005515;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;transporter activity#GO:0005215;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;voltage-gated sodium channel activity#GO:0005248;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;signaling receptor binding#GO:0005102;small molecule binding#GO:0036094;ion binding#GO:0043167;potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;voltage-gated calcium channel activity#GO:0005245;channel activity#GO:0015267;cation binding#GO:0043169;passive transmembrane transporter activity#GO:0022803;sodium channel activity#GO:0005272;calcium channel activity#GO:0005262;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261;sodium ion transmembrane transporter activity#GO:0015081 cellular process#GO:0009987;release of sequestered calcium ion into cytosol#GO:0051209;response to mechanical stimulus#GO:0009612;detection of stimulus#GO:0051606;monoatomic ion transmembrane transport#GO:0034220;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813;transport#GO:0006810;detection of mechanical stimulus#GO:0050982;calcium ion transport#GO:0006816;response to external stimulus#GO:0009605;establishment of localization#GO:0051234;calcium ion transmembrane import into cytosol#GO:0097553;response to abiotic stimulus#GO:0009628;calcium ion transmembrane transport#GO:0070588;metal ion transport#GO:0030001;response to stimulus#GO:0050896;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179 membrane#GO:0016020;cellular anatomical structure#GO:0110165 ion channel#PC00133 HUMAN|HGNC=5034|UniProtKB=Q99729 Q99729 HNRNPAB PTHR48033:SF1 RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A_B RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;chromosome#GO:0005694;organelle lumen#GO:0043233;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;membraneless organelle#GO:0043228;membrane-enclosed lumen#GO:0031974;chromatin#GO:0000785;nucleus#GO:0005634;intracellular membraneless organelle#GO:0043232 RNA metabolism protein#PC00031 HUMAN|HGNC=28889|UniProtKB=Q9Y3Q3 Q9Y3Q3 TMED3 PTHR22811:SF60 TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN 3 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;cargo adaptor activity#GO:0140312 protein transport#GO:0015031;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;localization#GO:0051179;Golgi organization#GO:0007030;cellular component organization#GO:0016043;intracellular protein transport#GO:0006886;Golgi vesicle transport#GO:0048193;transport#GO:0006810;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;organelle organization#GO:0006996;macromolecule localization#GO:0033036;endomembrane system organization#GO:0010256;vesicle-mediated transport#GO:0016192 intracellular organelle#GO:0043229;coated membrane#GO:0048475;membrane coat#GO:0030117;COPII-coated ER to Golgi transport vesicle#GO:0030134;membrane-bounded organelle#GO:0043227;coated vesicle#GO:0030135;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;vesicle#GO:0031982;organelle#GO:0043226;COPI vesicle coat#GO:0030126;cellular anatomical structure#GO:0110165;coated vesicle membrane#GO:0030662;Golgi-associated vesicle membrane#GO:0030660;intracellular membrane-bounded organelle#GO:0043231;Golgi-associated vesicle#GO:0005798;Golgi apparatus#GO:0005794;endoplasmic reticulum#GO:0005783;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;vesicle membrane#GO:0012506;membrane#GO:0016020;COPI-coated vesicle#GO:0030137;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;vesicle coat#GO:0030120;cytoplasm#GO:0005737 membrane traffic protein#PC00150;vesicle coat protein#PC00235 HUMAN|HGNC=941|UniProtKB=Q9UL15 Q9UL15 BAG5 PTHR12329:SF2 BCL2-ASSOCIATED ATHANOGENE BAG FAMILY MOLECULAR CHAPERONE REGULATOR 5 binding#GO:0005488;protein-folding chaperone binding#GO:0051087;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;protein binding#GO:0005515;nucleoside-triphosphatase regulator activity#GO:0060589 regulation of post-translational protein modification#GO:1901873;regulation of biological quality#GO:0065008;negative regulation of protein ubiquitination#GO:0031397;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;regulation of cellular component biogenesis#GO:0044087;negative regulation of protein metabolic process#GO:0051248;negative regulation of biological process#GO:0048519;regulation of protein modification by small protein conjugation or removal#GO:1903320;regulation of biological process#GO:0050789;regulation of protein modification process#GO:0031399;protein stabilization#GO:0050821;negative regulation of cellular process#GO:0048523;regulation of protein ubiquitination#GO:0031396;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of protein stability#GO:0031647;negative regulation of macromolecule metabolic process#GO:0010605 membrane#GO:0016020;cytosol#GO:0005829;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 chaperone#PC00072 HUMAN|HGNC=1544|UniProtKB=Q8IUK8 Q8IUK8 CBLN2 PTHR22923:SF50 CEREBELLIN-RELATED CEREBELLIN-2 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=169|UniProtKB=P61160 P61160 ACTR2 PTHR11937:SF409 ACTIN ACTIN-RELATED PROTEIN 2 cytoskeletal protein binding#GO:0008092;structural molecule activity#GO:0005198;actin binding#GO:0003779;actin filament binding#GO:0051015;structural constituent of cytoskeleton#GO:0005200;binding#GO:0005488;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;actin nucleation#GO:0045010;Arp2/3 complex-mediated actin nucleation#GO:0034314;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996 cytoskeleton#GO:0005856;Arp2/3 protein complex#GO:0005885;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;actin cytoskeleton#GO:0015629;cell periphery#GO:0071944;cell cortex#GO:0005938;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232 actin and actin related protein#PC00039 Huntington disease#P00029>Actin#P00807;Cadherin signaling pathway#P00012>F-actin#P00470;Alzheimer disease-presenilin pathway#P00004>actin#P00114 HUMAN|HGNC=28777|UniProtKB=Q9H773 Q9H773 DCTPP1 PTHR46523:SF1 DCTP PYROPHOSPHATASE 1 DCTP PYROPHOSPHATASE 1 hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;pyrophosphatase activity#GO:0016462;nucleoside triphosphate diphosphatase activity#GO:0047429;hydrolase activity#GO:0016787 DNA metabolic process#GO:0006259;nucleotide catabolic process#GO:0009166;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;pyrimidine-containing compound metabolic process#GO:0072527;carbohydrate derivative metabolic process#GO:1901135;response to stress#GO:0006950;nucleobase-containing compound catabolic process#GO:0034655;organophosphate metabolic process#GO:0019637;nucleobase-containing compound metabolic process#GO:0006139;cellular response to stress#GO:0033554;organophosphate catabolic process#GO:0046434;nucleotide metabolic process#GO:0009117;cellular response to stimulus#GO:0051716;nucleic acid metabolic process#GO:0090304;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;carbohydrate derivative catabolic process#GO:1901136;nucleoside phosphate metabolic process#GO:0006753;nucleoside phosphate catabolic process#GO:1901292;response to stimulus#GO:0050896;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 phosphatase#PC00181;hydrolase#PC00121 HUMAN|HGNC=25340|UniProtKB=Q86V97 Q86V97 KBTBD6 PTHR24412:SF385 KELCH PROTEIN KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 6 enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;proteasomal protein catabolic process#GO:0010498;cellular process#GO:0009987;regulation of small GTPase mediated signal transduction#GO:0051056;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;regulation of response to stimulus#GO:0048583;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;regulation of cell communication#GO:0010646;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531 ubiquitin ligase complex#GO:0000151;Cul3-RING ubiquitin ligase complex#GO:0031463;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;transferase complex#GO:1990234;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;cullin-RING ubiquitin ligase complex#GO:0031461 scaffold/adaptor protein#PC00226 HUMAN|HGNC=25225|UniProtKB=Q8TBH0 Q8TBH0 ARRDC2 PTHR11188:SF48 ARRESTIN DOMAIN CONTAINING PROTEIN ARRESTIN DOMAIN-CONTAINING PROTEIN 2 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=8068|UniProtKB=P52948 P52948 NUP98 PTHR23198:SF6 NUCLEOPORIN NUCLEAR PORE COMPLEX PROTEIN NUP98-NUP96 structural molecule activity#GO:0005198;structural constituent of nuclear pore#GO:0017056;RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 macromolecule localization#GO:0033036;import into nucleus#GO:0051170;protein localization to nucleus#GO:0034504;nitrogen compound transport#GO:0071705;post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery#GO:0000973;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;chromosome organization#GO:0051276;RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907;transport#GO:0006810;nucleobase-containing compound transport#GO:0015931;protein localization to organelle#GO:0033365;RNA localization#GO:0006403;transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery#GO:0000972;RNA transport#GO:0050658;establishment of RNA localization#GO:0051236;telomere localization#GO:0034397;localization#GO:0051179;nucleic acid transport#GO:0050657;nuclear transport#GO:0051169;nuclear export#GO:0051168;organelle localization#GO:0051640;nucleocytoplasmic transport#GO:0006913;chromosome localization#GO:0050000;organelle organization#GO:0006996;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;intracellular protein transport#GO:0006886;cellular component organization#GO:0016043;cellular localization#GO:0051641;protein import into nucleus#GO:0006606;protein transport#GO:0015031;telomere tethering at nuclear periphery#GO:0034398 nucleus#GO:0005634;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear pore#GO:0005643;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 transporter#PC00227 HUMAN|HGNC=25492|UniProtKB=Q5PRF9 Q5PRF9 SAMD4B PTHR12515:SF9 STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 4-RELATED PROTEIN SMAUG HOMOLOG 2 binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723 regulation of mRNA stability#GO:0043488;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;regulation of biological quality#GO:0065008;RNA metabolic process#GO:0016070;positive regulation of metabolic process#GO:0009893;RNA catabolic process#GO:0006401;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;RNA destabilization#GO:0050779;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of mRNA metabolic process#GO:1903311;macromolecule catabolic process#GO:0009057;mRNA destabilization#GO:0061157;positive regulation of mRNA metabolic process#GO:1903313;metabolic process#GO:0008152;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;nuclear-transcribed mRNA poly(A) tail shortening#GO:0000289;positive regulation of mRNA catabolic process#GO:0061014;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of RNA metabolic process#GO:0051252;regulation of RNA stability#GO:0043487;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;nucleic acid catabolic process#GO:0141188;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;nucleobase-containing compound catabolic process#GO:0034655;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;positive regulation of catabolic process#GO:0009896;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;macromolecule metabolic process#GO:0043170;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608 cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;organelle#GO:0043226;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;P-body#GO:0000932 HUMAN|HGNC=16429|UniProtKB=O43766 O43766 LIAS PTHR10949:SF0 LIPOYL SYNTHASE LIPOYL SYNTHASE, MITOCHONDRIAL sulfurtransferase activity#GO:0016783;transferase activity, transferring sulphur-containing groups#GO:0016782;transferase activity#GO:0016740;catalytic activity#GO:0003824 carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid biosynthetic process#GO:0046394;small molecule metabolic process#GO:0044281;oxoacid metabolic process#GO:0043436;sulfur compound metabolic process#GO:0006790;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058;fatty acid biosynthetic process#GO:0006633;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;monocarboxylic acid biosynthetic process#GO:0072330 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739 Lipoate_biosynthesis#P02750>Lipoate synthase#P03004 HUMAN|HGNC=14673|UniProtKB=Q9BQS8 Q9BQS8 FYCO1 PTHR46753:SF2 FYVE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1 FYVE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1 positive regulation of macroautophagy#GO:0016239;establishment of organelle localization#GO:0051656;regulation of cellular component organization#GO:0051128;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of autophagy#GO:0010506;positive regulation of organelle organization#GO:0010638;cellular localization#GO:0051641;positive regulation of metabolic process#GO:0009893;positive regulation of cellular component organization#GO:0051130;microtubule-based transport#GO:0099111;organelle transport along microtubule#GO:0072384;establishment of vesicle localization#GO:0051650;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;establishment of localization in cell#GO:0051649;regulation of protein-containing complex disassembly#GO:0043244;positive regulation of autophagy#GO:0010508;microtubule-based process#GO:0007017;regulation of macroautophagy#GO:0016241;regulation of cellular process#GO:0050794;microtubule-based movement#GO:0007018;localization#GO:0051179;organelle localization#GO:0051640;biological regulation#GO:0065007;cytoskeleton-dependent intracellular transport#GO:0030705;positive regulation of cellular process#GO:0048522;vesicle localization#GO:0051648;regulation of metabolic process#GO:0019222;regulation of catabolic process#GO:0009894;vesicle cytoskeletal trafficking#GO:0099518;transport along microtubule#GO:0010970;positive regulation of catabolic process#GO:0009896;establishment of localization#GO:0051234;transport#GO:0006810;regulation of autophagosome maturation#GO:1901096;intracellular transport#GO:0046907;vesicle transport along microtubule#GO:0047496 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;lysosome#GO:0005764;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;intracellular organelle#GO:0043229;autophagosome#GO:0005776;cytoplasm#GO:0005737;vacuole#GO:0005773;endomembrane system#GO:0012505;late endosome#GO:0005770;lytic vacuole#GO:0000323 HUMAN|HGNC=20366|UniProtKB=Q6UWI4 Q6UWI4 SHISA2 PTHR31395:SF0 SHISA PROTEIN SHISA-2 HOMOLOG regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111;regulation of cellular process#GO:0050794;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;regulation of fibroblast growth factor receptor signaling pathway#GO:0040036;regulation of cellular response to growth factor stimulus#GO:0090287;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of signal transduction#GO:0009968;negative regulation of Wnt signaling pathway#GO:0030178;negative regulation of response to stimulus#GO:0048585 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 scaffold/adaptor protein#PC00226 HUMAN|HGNC=20072|UniProtKB=Q70EL4 Q70EL4 USP43 PTHR21646:SF20 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 43 deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;cysteine-type deubiquitinase activity#GO:0004843;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity, acting on a protein#GO:0140096 biological regulation#GO:0065007;regulation of biological quality#GO:0065008;regulation of protein stability#GO:0031647 cysteine protease#PC00081 HUMAN|HGNC=5125|UniProtKB=P31276 P31276 HOXC13 PTHR45804:SF5 SEGMENTATION PROTEIN FUSHI TARAZU-LIKE PROTEIN HOMEOBOX PROTEIN HOX-C13 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=24041|UniProtKB=Q86V24 Q86V24 ADIPOR2 PTHR20855:SF33 ADIPOR/PROGESTIN RECEPTOR-RELATED ADIPONECTIN RECEPTOR PROTEIN 2 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;cellular response to stimulus#GO:0051716;response to endogenous stimulus#GO:0009719;signaling#GO:0023052;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;cellular response to hormone stimulus#GO:0032870;regulation of cellular process#GO:0050794;cellular response to chemical stimulus#GO:0070887;cytokine-mediated signaling pathway#GO:0019221;response to peptide#GO:1901652;cell communication#GO:0007154;hormone-mediated signaling pathway#GO:0009755;signal transduction#GO:0007165;cellular process#GO:0009987;response to hormone#GO:0009725;biological regulation#GO:0065007;response to chemical#GO:0042221;response to cytokine#GO:0034097;cell surface receptor signaling pathway#GO:0007166 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 Gonadotropin-releasing hormone receptor pathway#P06664>AdipoR1/R2#P06706 HUMAN|HGNC=23053|UniProtKB=Q86UN3 Q86UN3 RTN4RL2 PTHR24373:SF272 SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN RETICULON-4 RECEPTOR-LIKE 2 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=6132|UniProtKB=P61371 P61371 ISL1 PTHR24204:SF4 INSULIN GENE ENHANCER PROTEIN INSULIN GENE ENHANCER PROTEIN ISL-1 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987 animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;neuron development#GO:0048666;axonogenesis#GO:0007409;cell fate commitment#GO:0045165;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cell morphogenesis#GO:0000902;cell differentiation#GO:0030154;cell projection organization#GO:0030030;regulation of transcription by RNA polymerase II#GO:0006357;cell development#GO:0048468;positive regulation of transcription by RNA polymerase II#GO:0045944;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell fate specification#GO:0001708;neuron differentiation#GO:0030182;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cell projection morphogenesis#GO:0048858;neuron projection development#GO:0031175;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;axon development#GO:0061564;neuron fate commitment#GO:0048663;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of DNA-templated transcription#GO:0045893;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;plasma membrane bounded cell projection organization#GO:0120036;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 Gonadotropin-releasing hormone receptor pathway#P06664>Isl-1#G06682;Gonadotropin-releasing hormone receptor pathway#P06664>Isl-1#P06791;Gonadotropin-releasing hormone receptor pathway#P06664>Isl-1#G06896 HUMAN|HGNC=2295|UniProtKB=P00450 P00450 CP PTHR11709:SF226 MULTI-COPPER OXIDASE CERULOPLASMIN catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 oxidase#PC00175 HUMAN|HGNC=497|UniProtKB=O75762 O75762 TRPA1 PTHR24123:SF124 ANKYRIN REPEAT-CONTAINING TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY A MEMBER 1 monoatomic cation channel activity#GO:0005261;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;ligand-gated calcium channel activity#GO:0099604;gated channel activity#GO:0022836 nervous system process#GO:0050877;sensory perception#GO:0007600;detection of chemical stimulus involved in sensory perception#GO:0050907;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;detection of chemical stimulus#GO:0009593;sensory perception of pain#GO:0019233;calcium ion transmembrane transport#GO:0070588;metal ion transport#GO:0030001;response to stimulus#GO:0050896;transport#GO:0006810;sensory perception of chemical stimulus#GO:0007606;calcium ion transport#GO:0006816;system process#GO:0003008;calcium ion transmembrane import into cytosol#GO:0097553;establishment of localization#GO:0051234;cellular process#GO:0009987;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;multicellular organismal process#GO:0032501;response to chemical#GO:0042221 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HUMAN|HGNC=51517|UniProtKB=A0A494C086 A0A494C086 SPDYE21 PTHR31156:SF15 WBSCR19-LIKE PROTEIN SPEEDY PROTEIN E10-RELATED HUMAN|HGNC=1049|UniProtKB=Q96G01 Q96G01 BICD1 PTHR31233:SF3 BICAUDAL D FAMILY MEMBER PROTEIN BICAUDAL D HOMOLOG 1 binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;cytoskeletal adaptor activity#GO:0008093;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877 regulation of transport#GO:0051049;intracellular protein localization#GO:0008104;regulation of localization#GO:0032879;microtubule-based process#GO:0007017;microtubule anchoring at microtubule organizing center#GO:0072393;cellular component organization or biogenesis#GO:0071840;microtubule anchoring#GO:0034453;regulation of endocytosis#GO:0030100;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;regulation of microtubule cytoskeleton organization#GO:0070507;positive regulation of endocytosis#GO:0045807;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of transport#GO:0051050;cellular process#GO:0009987;organelle organization#GO:0006996;macromolecule localization#GO:0033036;localization#GO:0051179;microtubule cytoskeleton organization#GO:0000226;positive regulation of cellular component organization#GO:0051130;regulation of microtubule-based process#GO:0032886;regulation of cytoskeleton organization#GO:0051493;regulation of receptor-mediated endocytosis#GO:0048259;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;protein localization to organelle#GO:0033365;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;regulation of organelle organization#GO:0033043;cellular component organization#GO:0016043 cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=37281|UniProtKB=C9JRZ8 C9JRZ8 AKR1B15 PTHR11732:SF197 ALDO/KETO REDUCTASE ALDO-KETO REDUCTASE FAMILY 1 MEMBER B15 alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;alcohol dehydrogenase (NADP+) activity#GO:0008106;oxidoreductase activity#GO:0016491 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 oxidoreductase#PC00176;reductase#PC00198 HUMAN|HGNC=15832|UniProtKB=Q96G97 Q96G97 BSCL2 PTHR21212:SF0 BERNARDINELLI-SEIP CONGENITAL LIPODYSTROPHY 2 HOMOLOG BSCL2 PROTEIN SEIPIN cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;lipid storage#GO:0019915;cellular component organization#GO:0016043;lipid droplet organization#GO:0034389;organelle organization#GO:0006996 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 HUMAN|HGNC=14458|UniProtKB=Q9UQC2 Q9UQC2 GAB2 PTHR45960:SF1 GRB2-ASSOCIATED-BINDING PROTEIN GRB2-ASSOCIATED-BINDING PROTEIN 2 receptor tyrosine kinase binding#GO:0030971;molecular adaptor activity#GO:0060090;signaling receptor complex adaptor activity#GO:0030159;protein kinase binding#GO:0019901;transmembrane receptor protein tyrosine kinase adaptor activity#GO:0005068;enzyme binding#GO:0019899;protein-macromolecule adaptor activity#GO:0030674;protein tyrosine kinase binding#GO:1990782;signaling receptor binding#GO:0005102;kinase binding#GO:0019900;binding#GO:0005488;protein binding#GO:0005515;signaling adaptor activity#GO:0035591 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cell communication#GO:0007154 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 PDGF signaling pathway#P00047>Grb2#P01148;EGF receptor signaling pathway#P00018>Gab#P00563 HUMAN|HGNC=15511|UniProtKB=Q9ULK5 Q9ULK5 VANGL2 PTHR20886:SF10 VANG-LIKE PROTEIN VANG-LIKE PROTEIN 2 signal transduction#GO:0007165;cellular process#GO:0009987;epithelium development#GO:0060429;tissue development#GO:0009888;biological regulation#GO:0065007;developmental process#GO:0032502;cell surface receptor signaling pathway#GO:0007166;morphogenesis of an epithelium#GO:0002009;non-canonical Wnt signaling pathway#GO:0035567;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;Wnt signaling pathway#GO:0016055;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;animal gross anatomical part developmental process#GO:0160108;tissue morphogenesis#GO:0048729;cell communication#GO:0007154;anatomical structure development#GO:0048856 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HUMAN|HGNC=2320|UniProtKB=Q9UBL6 Q9UBL6 CPNE7 PTHR10857:SF6 COPINE COPINE-7 phospholipid binding#GO:0005543;binding#GO:0005488;lipid binding#GO:0008289 cellular response to chemical stimulus#GO:0070887;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to metal ion#GO:0010038;response to chemical#GO:0042221;response to calcium ion#GO:0051592;response to stimulus#GO:0050896 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 calcium-binding protein#PC00060 HUMAN|HGNC=18003|UniProtKB=Q7RTU3 Q7RTU3 OLIG3 PTHR19290:SF96 BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED OLIGODENDROCYTE TRANSCRIPTION FACTOR 3 RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 cell differentiation#GO:0030154;cell projection organization#GO:0030030;regulation of transcription by RNA polymerase II#GO:0006357;cell development#GO:0048468;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;positive regulation of macromolecule metabolic process#GO:0010604;nervous system development#GO:0007399;neuron projection development#GO:0031175;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;animal organ development#GO:0048513;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;positive regulation of transcription by RNA polymerase II#GO:0045944;neuron differentiation#GO:0030182;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;positive regulation of DNA-templated transcription#GO:0045893;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;plasma membrane bounded cell projection organization#GO:0120036;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;axon development#GO:0061564;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;sensory organ development#GO:0007423;developmental process#GO:0032502 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=25909|UniProtKB=Q8N4T4 Q8N4T4 ARHGEF39 PTHR47056:SF1 RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 39 RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 39 regulation of cell migration#GO:0030334;positive regulation of locomotion#GO:0040017;regulation of cell motility#GO:2000145;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;positive regulation of cell migration#GO:0030335;positive regulation of cell motility#GO:2000147;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein modulator#PC00022;protein-binding activity modulator#PC00095;guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=7175|UniProtKB=P22894 P22894 MMP8 PTHR10201:SF137 MATRIX METALLOPROTEINASE NEUTROPHIL COLLAGENASE metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;metalloendopeptidase activity#GO:0004222;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096 cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;external encapsulating structure organization#GO:0045229;metabolic process#GO:0008152;extracellular structure organization#GO:0043062;catabolic process#GO:0009056;cellular component organization#GO:0016043;cellular process#GO:0009987 metalloprotease#PC00153 Alzheimer disease-presenilin pathway#P00004>Matrix metalloprotease#P00130;Plasminogen activating cascade#P00050>MMP-13#P01250;Plasminogen activating cascade#P00050>pro-MMP-13#P01254 HUMAN|HGNC=28039|UniProtKB=Q9NPI7 Q9NPI7 KRCC1 PTHR46742:SF3 LYSINE-RICH COILED-COIL PROTEIN 1 LYSINE-RICH COILED-COIL PROTEIN 1 HUMAN|HGNC=2771|UniProtKB=P00746 P00746 CFD PTHR24271:SF54 KALLIKREIN-RELATED COMPLEMENT FACTOR D catalytic activity#GO:0003824;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;serine-type peptidase activity#GO:0008236;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 serine protease#PC00203 HUMAN|HGNC=30622|UniProtKB=Q08AE8 Q08AE8 SPIRE1 PTHR21345:SF8 SPIRE PROTEIN SPIRE HOMOLOG 1 protein binding#GO:0005515;binding#GO:0005488;microtubule binding#GO:0008017;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092 membrane organization#GO:0061024;establishment of spindle localization#GO:0051293;establishment of localization#GO:0051234;meiotic nuclear division#GO:0140013;actin filament organization#GO:0007015;intracellular transport#GO:0046907;transport#GO:0006810;actin cytoskeleton organization#GO:0030036;reproductive process#GO:0022414;cell cycle#GO:0007049;cell division#GO:0051301;localization#GO:0051179;organelle fission#GO:0048285;microtubule cytoskeleton organization#GO:0000226;supramolecular fiber organization#GO:0097435;multicellular organismal reproductive process#GO:0048609;organelle localization#GO:0051640;sexual reproduction#GO:0019953;actin filament-based process#GO:0030029;vesicle-mediated transport#GO:0016192;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;meiotic cell cycle#GO:0051321;membrane invagination#GO:0010324;Golgi vesicle transport#GO:0048193;establishment of organelle localization#GO:0051656;gamete generation#GO:0007276;meiotic cell cycle process#GO:1903046;cellular component organization#GO:0016043;cell cycle process#GO:0022402;cytoskeleton-dependent cytokinesis#GO:0061640;cellular localization#GO:0051641;spindle localization#GO:0051653;cytokinesis#GO:0000910;nuclear division#GO:0000280;cytokinetic process#GO:0032506 intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cell cortex#GO:0005938;organelle membrane#GO:0031090;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;membrane#GO:0016020;vesicle membrane#GO:0012506;cell periphery#GO:0071944 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=18260|UniProtKB=Q9NX57 Q9NX57 RAB20 PTHR24073:SF941 DRAB5-RELATED RAS-RELATED PROTEIN RAB-20 ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818 cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;macromolecule localization#GO:0033036;endocytosis#GO:0006897;transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;protein transport#GO:0015031;intracellular protein localization#GO:0008104;import into cell#GO:0098657;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179 membrane#GO:0016020;cell periphery#GO:0071944;endomembrane system#GO:0012505;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;endocytic vesicle#GO:0030139;early endosome#GO:0005769;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410 G-protein#PC00020;small GTPase#PC00208 HUMAN|HGNC=13158|UniProtKB=P51522 P51522 ZNF83 PTHR23226:SF324 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER PROTEIN 83 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=2232|UniProtKB=P35606 P35606 COPB2 PTHR19876:SF2 COATOMER COATOMER SUBUNIT BETA' establishment of localization#GO:0051234;vesicle-mediated transport#GO:0016192;localization#GO:0051179;transport#GO:0006810;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890 intracellular organelle#GO:0043229;coated membrane#GO:0048475;membrane coat#GO:0030117;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;coated vesicle#GO:0030135;cytoplasmic vesicle#GO:0031410;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;COPI vesicle coat#GO:0030126;cellular anatomical structure#GO:0110165;Golgi-associated vesicle membrane#GO:0030660;coated vesicle membrane#GO:0030662;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;Golgi-associated vesicle#GO:0005798;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;vesicle membrane#GO:0012506;membrane#GO:0016020;COPI-coated vesicle#GO:0030137;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;vesicle coat#GO:0030120;cytoplasm#GO:0005737 vesicle coat protein#PC00235 HUMAN|HGNC=31092|UniProtKB=Q24JP5 Q24JP5 TMEM132A PTHR13388:SF9 DETONATOR, ISOFORM E TRANSMEMBRANE PROTEIN 132A regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;positive regulation of response to stimulus#GO:0048584;positive regulation of Wnt signaling pathway#GO:0030177 cellular anatomical structure#GO:0110165;membrane#GO:0016020 HUMAN|HGNC=25667|UniProtKB=Q9HAI6 Q9HAI6 TASL PTHR14889:SF3 RCG36411 TLR ADAPTER INTERACTING WITH SLC15A4 ON THE LYSOSOME HUMAN|HGNC=8895|UniProtKB=P53609 P53609 PGGT1B PTHR11774:SF4 GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT GERANYLGERANYL TRANSFERASE TYPE-1 SUBUNIT BETA prenyltransferase activity#GO:0004659;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096 intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;transferase complex#GO:1990234 acyltransferase#PC00042;transferase#PC00220 HUMAN|HGNC=15524|UniProtKB=Q86VZ1 Q86VZ1 P2RY8 PTHR24232:SF25 G-PROTEIN COUPLED RECEPTOR S-GERANYLGERANYL-GLUTATHIONE RECEPTOR P2RY8 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=7397|UniProtKB=P04732 P04732 MT1E PTHR23299:SF24 METALLOTHIONEIN METALLOTHIONEIN-1E-RELATED defense/immunity protein#PC00090 HUMAN|HGNC=26009|UniProtKB=Q8TE82 Q8TE82 SH3TC1 PTHR22647:SF3 SH3 DOMAIN AND TETRATRICOPEPTIDE REPEATS CONTAINING PROTEIN SH3 DOMAIN AND TETRATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 1 scaffold/adaptor protein#PC00226 HUMAN|HGNC=25967|UniProtKB=Q9NXL6 Q9NXL6 SIDT1 PTHR12185:SF15 SID1 TRANSMEMBRANE FAMILY MEMEBER SID1 TRANSMEMBRANE FAMILY MEMBER 1 binding#GO:0005488;nucleic acid binding#GO:0003676;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;double-stranded RNA binding#GO:0003725;nucleobase-containing compound transmembrane transporter activity#GO:0015932;RNA binding#GO:0003723 transport#GO:0006810;establishment of localization#GO:0051234;nucleic acid transport#GO:0050657;localization#GO:0051179;nitrogen compound transport#GO:0071705;macromolecule localization#GO:0033036;RNA localization#GO:0006403;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;establishment of RNA localization#GO:0051236 plasma membrane#GO:0005886;vacuole#GO:0005773;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;lysosome#GO:0005764;cell periphery#GO:0071944;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;lytic vacuole#GO:0000323;intracellular organelle#GO:0043229 HUMAN|HGNC=3642|UniProtKB=P22570 P22570 FDXR PTHR11938:SF151 FAD NADPH DEHYDROGENASE/OXIDOREDUCTASE NADPH:ADRENODOXIN OXIDOREDUCTASE, MITOCHONDRIAL catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 steroid biosynthetic process#GO:0006694;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;steroid metabolic process#GO:0008202;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;cellular process#GO:0009987;primary metabolic process#GO:0044238 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 Vitamin D metabolism and pathway#P04396>FdxR#P04604 HUMAN|HGNC=27829|UniProtKB=Q7Z388 Q7Z388 DPY19L4 PTHR31488:SF2 DPY-19-LIKE 1, LIKE (H. SAPIENS) C-MANNOSYLTRANSFERASE DPY19L4-RELATED hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740;mannosyltransferase activity#GO:0000030;glycosyltransferase activity#GO:0016757 endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 HUMAN|HGNC=11743|UniProtKB=Q92481 Q92481 TFAP2B PTHR10812:SF14 TRANSCRIPTION FACTOR AP-2 TRANSCRIPTION FACTOR AP-2-BETA transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription activator activity#GO:0001216;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of cell population proliferation#GO:0042127;positive regulation of biosynthetic process#GO:0009891;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;positive regulation of DNA-templated transcription#GO:0045893;multicellular organismal process#GO:0032501;negative regulation of apoptotic process#GO:0043066;regulation of nucleobase-containing compound metabolic process#GO:0019219;animal gross anatomical part developmental process#GO:0160108;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;regulation of transcription by RNA polymerase II#GO:0006357;regulation of apoptotic process#GO:0042981;positive regulation of transcription by RNA polymerase II#GO:0045944;multicellular organism development#GO:0007275;positive regulation of biological process#GO:0048518;negative regulation of programmed cell death#GO:0043069;nervous system development#GO:0007399;positive regulation of macromolecule metabolic process#GO:0010604 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031;general transcription factor#PC00259 HUMAN|HGNC=20665|UniProtKB=Q9NY72 Q9NY72 SCN3B PTHR10546:SF1 SODIUM CHANNEL SUBUNIT BETA-1 AND 3 SODIUM CHANNEL REGULATORY SUBUNIT BETA-3 molecular function regulator activity#GO:0098772;ion channel inhibitor activity#GO:0008200;ion channel regulator activity#GO:0099106;protein binding#GO:0005515;channel regulator activity#GO:0016247;molecular function inhibitor activity#GO:0140678;binding#GO:0005488;transporter regulator activity#GO:0141108;transmembrane transporter binding#GO:0044325 circulatory system process#GO:0003013;cardiac muscle contraction#GO:0060048;actin filament-based process#GO:0030029;localization#GO:0051179;monoatomic cation transport#GO:0006812;actin-mediated cell contraction#GO:0070252;metal ion transport#GO:0030001;striated muscle contraction#GO:0006941;membrane depolarization#GO:0051899;regulation of heart contraction#GO:0008016;regulation of system process#GO:0044057;muscle contraction#GO:0006936;transport#GO:0006810;establishment of localization#GO:0051234;cardiac muscle cell contraction#GO:0086003;system process#GO:0003008;heart contraction#GO:0060047;actin filament-based movement#GO:0030048;blood circulation#GO:0008015;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;action potential#GO:0001508;muscle system process#GO:0003012;regulation of biological process#GO:0050789;heart process#GO:0003015;sodium ion transport#GO:0006814;regulation of membrane potential#GO:0042391;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;cardiac muscle cell action potential involved in contraction#GO:0086002;monoatomic cation transmembrane transport#GO:0098655;regulation of multicellular organismal process#GO:0051239 monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane protein complex#GO:0098796;membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;sodium channel complex#GO:0034706;cation channel complex#GO:0034703 ion channel#PC00133;voltage-gated ion channel#PC00241 HUMAN|HGNC=17993|UniProtKB=Q8TD43 Q8TD43 TRPM4 PTHR13800:SF6 TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6 TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 4 gated channel activity#GO:0022836;calcium ion transmembrane transporter activity#GO:0015085;ligand-gated calcium channel activity#GO:0099604;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;ligand-gated monoatomic ion channel activity#GO:0015276;calcium-activated cation channel activity#GO:0005227;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;monoatomic ion-gated channel activity#GO:0022839;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;ligand-gated monoatomic cation channel activity#GO:0099094;monoatomic cation channel activity#GO:0005261 transport#GO:0006810;monoatomic ion transport#GO:0006811;calcium ion transport#GO:0006816;monoatomic cation transport#GO:0006812;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;cellular process#GO:0009987;calcium ion transmembrane transport#GO:0070588;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;monoatomic ion transmembrane transport#GO:0034220 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=5580|UniProtKB=P01762 P01762 IGHV3-11 PTHR23266:SF357 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 3-11-RELATED binding#GO:0005488;antigen binding#GO:0003823 leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;immune system process#GO:0002376;immune effector process#GO:0002252;response to stimulus#GO:0050896;adaptive immune response#GO:0002250;immune response#GO:0006955 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=23067|UniProtKB=Q8IUR0 Q8IUR0 TRAPPC5 PTHR20902:SF0 41-2 PROTEIN ANTIGEN-RELATED TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 5 endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;Golgi vesicle transport#GO:0048193;transport#GO:0006810;intracellular transport#GO:0046907;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649 TRAPP complex#GO:0030008;cytoplasm#GO:0005737;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;Golgi apparatus#GO:0005794;intracellular protein-containing complex#GO:0140535;vesicle tethering complex#GO:0099023;TRAPPII protein complex#GO:1990071;vesicle#GO:0031982;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=24055|UniProtKB=Q8NFQ8 Q8NFQ8 TOR1AIP2 PTHR18843:SF2 TORSIN-1A-INTERACTING PROTEIN TORSIN-1A-INTERACTING PROTEIN 2 cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;endoplasmic reticulum organization#GO:0007029;cellular component organization or biogenesis#GO:0071840;endomembrane system organization#GO:0010256;membrane organization#GO:0061024 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 HUMAN|HGNC=8161|UniProtKB=Q9H208 Q9H208 OR10A2 PTHR26453:SF625 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 10A2 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;response to stimulus#GO:0050896;response to chemical#GO:0042221;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;detection of chemical stimulus#GO:0009593;system process#GO:0003008;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;nervous system process#GO:0050877;sensory perception#GO:0007600 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=18731|UniProtKB=Q9BQ51 Q9BQ51 PDCD1LG2 PTHR25466:SF1 T-LYMPHOCYTE ACTIVATION ANTIGEN PROGRAMMED CELL DEATH 1 LIGAND 2 signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677 regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;negative regulation of signal transduction#GO:0009968;biological regulation#GO:0065007;negative regulation of immune system process#GO:0002683;regulation of signal transduction#GO:0009966;negative regulation of response to stimulus#GO:0048585;immune response#GO:0006955;negative regulation of cell communication#GO:0010648;regulation of signaling#GO:0023051;regulation of immune response#GO:0050776;negative regulation of signaling#GO:0023057;immune system process#GO:0002376;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519 cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020;plasma membrane#GO:0005886;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=23242|UniProtKB=Q8IUC8 Q8IUC8 GALNT13 PTHR11675:SF47 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 13 polypeptide N-acetylgalactosaminyltransferase activity#GO:0004653;catalytic activity, acting on a protein#GO:0140096;UDP-glycosyltransferase activity#GO:0008194;acetylgalactosaminyltransferase activity#GO:0008376;glycosyltransferase activity#GO:0016757;hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740 primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein O-linked glycosylation#GO:0006493;carbohydrate derivative metabolic process#GO:1901135;biosynthetic process#GO:0009058;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 glycosyltransferase#PC00111;transferase#PC00220 HUMAN|HGNC=13703|UniProtKB=Q9BXY0 Q9BXY0 MAK16 PTHR23405:SF4 MAINTENANCE OF KILLER 16 MAK16 PROTEIN-RELATED PROTEIN MAK16 HOMOLOG macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;gene expression#GO:0010467;maturation of LSU-rRNA#GO:0000470;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;ribosomal large subunit biogenesis#GO:0042273;ribonucleoprotein complex biogenesis#GO:0022613;maturation of 5.8S rRNA#GO:0000460;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 membraneless organelle#GO:0043228;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;preribosome#GO:0030684;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;preribosome, large subunit precursor#GO:0030687;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=10912|UniProtKB=P55017 P55017 SLC12A3 PTHR11827:SF9 SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS SOLUTE CARRIER FAMILY 12 MEMBER 3 monoatomic cation transmembrane transporter activity#GO:0008324;potassium ion transmembrane transporter activity#GO:0015079;solute:sodium symporter activity#GO:0015370;symporter activity#GO:0015293;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;secondary active transmembrane transporter activity#GO:0015291;monoatomic anion transmembrane transporter activity#GO:0008509;chloride transmembrane transporter activity#GO:0015108 transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698;monoatomic anion transport#GO:0006820;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;chloride transport#GO:0006821;transport#GO:0006810;establishment of localization#GO:0051234;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805 plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;apical plasma membrane#GO:0016324;membrane#GO:0016020;apical part of cell#GO:0045177;cell periphery#GO:0071944 secondary carrier transporter#PC00258 HUMAN|HGNC=11842|UniProtKB=Q86UE8 Q86UE8 TLK2 PTHR22974:SF20 MIXED LINEAGE PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE TOUSLED-LIKE 2 catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 cell cycle#GO:0007049;cellular process#GO:0009987;cell cycle process#GO:0022402;chromosome segregation#GO:0007059 organelle#GO:0043226;cellular anatomical structure#GO:0110165;perinuclear region of cytoplasm#GO:0048471;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=13826|UniProtKB=Q5VZB9 Q5VZB9 DMRTA1 PTHR12322:SF71 DOUBLESEX AND MAB-3 RELATED TRANSCRIPTION FACTOR DMRT DOUBLESEX- AND MAB-3-RELATED TRANSCRIPTION FACTOR A1 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987 developmental process#GO:0032502;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;sex differentiation#GO:0007548;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;developmental process involved in reproduction#GO:0003006;reproductive process#GO:0022414;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218 HUMAN|HGNC=5019|UniProtKB=A6NHT5 A6NHT5 HMX3 PTHR46110:SF2 HOMEOBOX PROTEIN HMX HOMEOBOX PROTEIN HMX3 transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 HUMAN|HGNC=16674|UniProtKB=Q5J8X5 Q5J8X5 MS4A13 PTHR23320:SF42 MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 13 transporter#PC00227 HUMAN|HGNC=29352|UniProtKB=Q6P9B9 Q6P9B9 INTS5 PTHR31697:SF2 INTEGRATOR COMPLEX SUBUNIT 5 INTEGRATOR COMPLEX SUBUNIT 5 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;snRNA processing#GO:0016180;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;snRNA 3'-end processing#GO:0034472;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;snRNA metabolic process#GO:0016073 nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;integrator complex#GO:0032039;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=91|UniProtKB=P45954 P45954 ACADSB PTHR43884:SF1 ACYL-COA DEHYDROGENASE SHORT_BRANCHED CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;catalytic activity#GO:0003824 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 oxidoreductase#PC00176;dehydrogenase#PC00092 HUMAN|HGNC=34492|UniProtKB=A8MV24 A8MV24 SPMAP1 PTHR34221:SF2 HYPOTHETICAL PROTEIN LOC691189 SPERM MICROTUBULE ASSOCIATED PROTEIN 1 HUMAN|HGNC=17017|UniProtKB=P62312 P62312 LSM6 PTHR11021:SF1 SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM6 nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 RNA splicing, via transesterification reactions#GO:0000375;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;rRNA processing#GO:0006364;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;ribosomal small subunit biogenesis#GO:0042274;RNA splicing#GO:0008380;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;mRNA processing#GO:0006397;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;maturation of SSU-rRNA#GO:0030490;biosynthetic process#GO:0009058 nucleolus#GO:0005730;P-body#GO:0000932;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;spliceosomal tri-snRNP complex#GO:0097526;spliceosomal snRNP complex#GO:0097525;sno(s)RNA-containing ribonucleoprotein complex#GO:0005732;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;organelle#GO:0043226;nuclear lumen#GO:0031981;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;U6 snRNP#GO:0005688;nuclear protein-containing complex#GO:0140513;Sm-like protein family complex#GO:0120114;membraneless organelle#GO:0043228;small nuclear ribonucleoprotein complex#GO:0030532;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;supramolecular complex#GO:0099080;U4/U6 x U5 tri-snRNP complex#GO:0046540;ribonucleoprotein granule#GO:0035770;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737 RNA splicing factor#PC00148 HUMAN|HGNC=7569|UniProtKB=P35749 P35749 MYH11 PTHR45615:SF23 MYOSIN HEAVY CHAIN, NON-MUSCLE MYOSIN-11 isomerase activity#GO:0016853;cytoskeletal motor activity#GO:0003774;macromolecular conformation isomerase activity#GO:0120543;cytoskeletal protein binding#GO:0008092;catalytic activity#GO:0003824;microfilament motor activity#GO:0000146;protein-containing complex binding#GO:0044877;protein binding#GO:0005515;actin filament binding#GO:0051015;actin binding#GO:0003779;ATP-dependent activity#GO:0140657;polypeptide conformation or assembly isomerase activity#GO:0120544;binding#GO:0005488 actin filament-based process#GO:0030029;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;actomyosin structure organization#GO:0031032;actin cytoskeleton organization#GO:0030036 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membraneless organelle#GO:0043228;actin cytoskeleton#GO:0015629;myosin complex#GO:0016459;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;supramolecular complex#GO:0099080;organelle#GO:0043226 actin or actin-binding cytoskeletal protein#PC00041 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Myosin#P00867;Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097;Cytoskeletal regulation by Rho GTPase#P00016>Myosin#P00522 HUMAN|HGNC=16900|UniProtKB=O75940 O75940 SMNDC1 PTHR13681:SF26 SURVIVAL OF MOTOR NEURON-RELATED-SPLICING FACTOR 30-RELATED SURVIVAL OF MOTOR NEURON-RELATED-SPLICING FACTOR 30 nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 RNA splicing factor#PC00148 HUMAN|HGNC=6229|UniProtKB=Q13303 Q13303 KCNAB2 PTHR43150:SF1 HYPERKINETIC, ISOFORM M VOLTAGE-GATED POTASSIUM CHANNEL SUBUNIT BETA-2 potassium channel regulator activity#GO:0015459;transmembrane transporter binding#GO:0044325;transporter regulator activity#GO:0141108;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;binding#GO:0005488;channel regulator activity#GO:0016247;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;protein binding#GO:0005515;ion channel regulator activity#GO:0099106;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824;molecular function regulator activity#GO:0098772;oxidoreductase activity#GO:0016491;alcohol dehydrogenase (NADP+) activity#GO:0008106 regulation of transmembrane transport#GO:0034762;regulation of monoatomic ion transmembrane transport#GO:0034765;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of monoatomic ion transport#GO:0043269;regulation of metal ion transport#GO:0010959;biological regulation#GO:0065007;regulation of monoatomic cation transmembrane transport#GO:1904062;regulation of transport#GO:0051049;regulation of localization#GO:0032879 protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005;main axon#GO:0044304;transporter complex#GO:1990351;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;transmembrane transporter complex#GO:1902495;axon#GO:0030424 HUMAN|HGNC=15142|UniProtKB=Q9H205 Q9H205 OR2AG1 PTHR26453:SF183 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2AG1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;response to chemical#GO:0042221;response to stimulus#GO:0050896;detection of chemical stimulus#GO:0009593;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;system process#GO:0003008;nervous system process#GO:0050877;sensory perception#GO:0007600;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=27036|UniProtKB=Q86SE5 Q86SE5 RALYL PTHR13968:SF21 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN RNA-BINDING RALY-LIKE PROTEIN RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031 HUMAN|HGNC=13014|UniProtKB=Q9UK13 Q9UK13 ZNF221 PTHR24388:SF109 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 221-RELATED sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=21246|UniProtKB=Q8N8W4 Q8N8W4 PNPLA1 PTHR12406:SF23 CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 IPLA2 -RELATED OMEGA-HYDROXYCERAMIDE TRANSACYLASE transferase activity#GO:0016740;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;lipase activity#GO:0016298;triacylglycerol lipase activity#GO:0004806;acyltransferase activity#GO:0016746;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity#GO:0016787 neutral lipid metabolic process#GO:0006638;acylglycerol catabolic process#GO:0046464;acylglycerol metabolic process#GO:0006639;sphingolipid biosynthetic process#GO:0030148;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;chemical homeostasis#GO:0048878;triglyceride metabolic process#GO:0006641;ceramide biosynthetic process#GO:0046513;neutral lipid catabolic process#GO:0046461;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058;cellular process#GO:0009987;lipid catabolic process#GO:0016042;ceramide metabolic process#GO:0006672;glycerolipid catabolic process#GO:0046503;triglyceride catabolic process#GO:0019433;catabolic process#GO:0009056;glycerolipid metabolic process#GO:0046486;homeostatic process#GO:0042592;lipid homeostasis#GO:0055088;primary metabolic process#GO:0044238 intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;lipid droplet#GO:0005811;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232 phospholipase#PC00186 HUMAN|HGNC=4188|UniProtKB=O75600 O75600 GCAT PTHR13693:SF105 CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE 2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE, MITOCHONDRIAL intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 transaminase#PC00216 HUMAN|HGNC=30460|UniProtKB=Q86UT8 Q86UT8 CENATAC PTHR31198:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 84 CENTROSOMAL AT-AC SPLICING FACTOR HUMAN|HGNC=13839|UniProtKB=Q8IWK6 Q8IWK6 ADGRA3 PTHR45930:SF2 G-PROTEIN COUPLED RECEPTOR 124-LIKE PROTEIN ADHESION G PROTEIN-COUPLED RECEPTOR A3 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166 plasma membrane#GO:0005886;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021 HUMAN|HGNC=7323|UniProtKB=Q9UHD8 Q9UHD8 SEPTIN9 PTHR18884:SF47 SEPTIN SEPTIN-9 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111 cytoskeleton-dependent cytokinesis#GO:0061640;localization#GO:0051179;intracellular protein localization#GO:0008104;cytokinesis#GO:0000910;cell cycle#GO:0007049;macromolecule localization#GO:0033036;cellular process#GO:0009987;cell cycle process#GO:0022402;cell division#GO:0051301 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cell division site#GO:0032153;microtubule cytoskeleton#GO:0015630;cell periphery#GO:0071944;cell cortex#GO:0005938;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 cytoskeletal protein#PC00085 HUMAN|HGNC=24304|UniProtKB=Q9BPX3 Q9BPX3 NCAPG PTHR14418:SF5 CONDENSIN COMPLEX SUBUNIT 3-RELATED CONDENSIN COMPLEX SUBUNIT 3 mitotic cell cycle#GO:0000278;cellular component organization#GO:0016043;nuclear chromosome segregation#GO:0098813;sister chromatid segregation#GO:0000819;cell cycle#GO:0007049;cell cycle process#GO:0022402;mitotic nuclear division#GO:0140014;organelle fission#GO:0048285;chromosome condensation#GO:0030261;mitotic chromosome condensation#GO:0007076;nuclear division#GO:0000280;organelle organization#GO:0006996;mitotic sister chromatid segregation#GO:0000070;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;chromosome organization#GO:0051276;mitotic cell cycle process#GO:1903047;chromosome segregation#GO:0007059 nucleus#GO:0005634;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;condensin complex#GO:0000796;condensed chromosome#GO:0000793;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 HUMAN|HGNC=25941|UniProtKB=Q6N021 Q6N021 TET2 PTHR23358:SF3 METHYLCYTOSINE DIOXYGENASE TET METHYLCYTOSINE DIOXYGENASE TET2 dioxygenase activity#GO:0051213;catalytic activity, acting on DNA#GO:0140097;oxidoreductase activity#GO:0016491;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705 regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;developmental process#GO:0032502;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;hemopoiesis#GO:0030097;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of biological process#GO:0050789;cell development#GO:0048468;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;myeloid cell differentiation#GO:0030099;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=10439|UniProtKB=Q96S38 Q96S38 RPS6KC1 PTHR15508:SF2 RIBOSOMAL PROTEIN S6 KINASE INACTIVE RIBOSOMAL PROTEIN S6 KINASE DELTA-1 vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;early endosome#GO:0005769 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 PDGF signaling pathway#P00047>p90RSK#P01142 HUMAN|HGNC=19868|UniProtKB=Q8TEW6 Q8TEW6 DOK4 PTHR21258:SF44 DOCKING PROTEIN RELATED DOCKING PROTEIN 4 enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789 scaffold/adaptor protein#PC00226 HUMAN|HGNC=27996|UniProtKB=P0DUQ2 P0DUQ2 PRAMEF9 PTHR14224:SF112 SIMILAR TO PREFERENTIALLY EXPRESSED ANTIGEN IN MELANOMA-LIKE 3 PRAME FAMILY MEMBER 11-RELATED molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;enzyme-substrate adaptor activity#GO:0140767;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;cullin-RING ubiquitin ligase complex#GO:0031461;ubiquitin ligase complex#GO:0000151;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;Cul2-RING ubiquitin ligase complex#GO:0031462;transferase complex#GO:1990234;catalytic complex#GO:1902494 HUMAN|HGNC=2595|UniProtKB=P04798 P04798 CYP1A1 PTHR24299:SF8 CYTOCHROME P450 FAMILY 1 CYTOCHROME P450 1A1 oxidoreductase activity#GO:0016491;monooxygenase activity#GO:0004497;catalytic activity#GO:0003824;steroid hydroxylase activity#GO:0008395 lipid catabolic process#GO:0016042;cellular process#GO:0009987;steroid metabolic process#GO:0008202;biological regulation#GO:0065007;cellular response to xenobiotic stimulus#GO:0071466;response to chemical#GO:0042221;hormone metabolic process#GO:0042445;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;secondary metabolic process#GO:0019748;regulation of hormone levels#GO:0010817;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;xenobiotic metabolic process#GO:0006805;response to stimulus#GO:0050896;catabolic process#GO:0009056;cellular response to chemical stimulus#GO:0070887;response to xenobiotic stimulus#GO:0009410;steroid catabolic process#GO:0006706;regulation of biological quality#GO:0065008;estrogen metabolic process#GO:0008210 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 oxidoreductase#PC00176;oxygenase#PC00177 HUMAN|HGNC=19983|UniProtKB=Q86YS6 Q86YS6 RAB43 PTHR24073:SF653 DRAB5-RELATED RAS-RELATED PROTEIN RAB-43 hydrolase activity, acting on acid anhydrides#GO:0016817;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787 cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;macromolecule localization#GO:0033036;transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;protein transport#GO:0015031;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 small GTPase#PC00208;G-protein#PC00020 HUMAN|HGNC=11507|UniProtKB=Q16563 Q16563 SYPL1 PTHR10306:SF9 SYNAPTOPHYSIN SYNAPTOPHYSIN-LIKE PROTEIN 1 secretory vesicle#GO:0099503;membrane#GO:0016020;vesicle membrane#GO:0012506;presynapse#GO:0098793;transport vesicle membrane#GO:0030658;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;transport vesicle#GO:0030133;cytoplasm#GO:0005737;cell junction#GO:0030054;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;intracellular vesicle#GO:0097708;synaptic vesicle#GO:0008021;synaptic vesicle membrane#GO:0030672;vesicle#GO:0031982;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227 membrane traffic protein#PC00150;membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=11159|UniProtKB=P62316 P62316 SNRPD2 PTHR12777:SF0 SMALL NUCLEAR RIBONUCLEOPROTEIN SM D2 SMALL NUCLEAR RIBONUCLEOPROTEIN SM D2 protein-containing complex organization#GO:0043933;protein-RNA complex organization#GO:0071826;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;gene expression#GO:0010467;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;cellular component biogenesis#GO:0044085;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;protein-RNA complex assembly#GO:0022618;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;ribonucleoprotein complex biogenesis#GO:0022613;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;spliceosomal snRNP assembly#GO:0000387;protein-containing complex assembly#GO:0065003;mRNA splicing, via spliceosome#GO:0000398;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular component organization#GO:0016043 spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;spliceosomal tri-snRNP complex#GO:0097526;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;precatalytic spliceosome#GO:0071011;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;spliceosomal snRNP complex#GO:0097525;nucleus#GO:0005634;small nuclear ribonucleoprotein complex#GO:0030532;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;U1 snRNP#GO:0005685;U4/U6 x U5 tri-snRNP complex#GO:0046540;U2 snRNP#GO:0005686;U5 snRNP#GO:0005682;catalytic step 2 spliceosome#GO:0071013;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513 RNA processing factor#PC00147 HUMAN|HGNC=8060|UniProtKB=P49757 P49757 NUMB PTHR47368:SF5 NUMB PROTEIN NUMB HOMOLOG regulation of cell development#GO:0060284;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of cell development#GO:0010720;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;positive regulation of cell differentiation#GO:0045597;regulation of cell differentiation#GO:0045595;positive regulation of developmental process#GO:0051094;regulation of multicellular organismal development#GO:2000026;positive regulation of multicellular organismal process#GO:0051240;regulation of biological process#GO:0050789;regulation of neurogenesis#GO:0050767;positive regulation of neurogenesis#GO:0050769;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;positive regulation of nervous system development#GO:0051962;regulation of nervous system development#GO:0051960 cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;basal part of cell#GO:0045178;intracellular vesicle#GO:0097708;vesicle#GO:0031982;plasma membrane region#GO:0098590;cytoplasm#GO:0005737;plasma membrane#GO:0005886;membrane#GO:0016020;basolateral plasma membrane#GO:0016323;cell periphery#GO:0071944;basal plasma membrane#GO:0009925 Notch signaling pathway#P00045>Numb#P01118 HUMAN|HGNC=34347|UniProtKB=A6NL82 A6NL82 CFAP144 PTHR33865:SF2 PROTEIN FAM183B CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 144 cilium#GO:0005929;ciliary base#GO:0097546;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=16475|UniProtKB=Q3SXM5 Q3SXM5 HSDL1 PTHR44889:SF1 INACTIVE HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1 INACTIVE HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1 mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 dehydrogenase#PC00092 HUMAN|HGNC=16177|UniProtKB=Q8N4F0 Q8N4F0 BPIFB2 PTHR46019:SF1 BPI FOLD-CONTAINING FAMILY B MEMBER 4-RELATED BPI FOLD-CONTAINING FAMILY B MEMBER 2 HUMAN|HGNC=20678|UniProtKB=Q6X784 Q6X784 ZPBP2 PTHR15443:SF4 ZONA PELLUCIDA BINDING PROTEIN SP38 ZONA PELLUCIDA-BINDING PROTEIN 2 HUMAN|HGNC=24537|UniProtKB=Q9UQN3 Q9UQN3 CHMP2B PTHR10476:SF72 CHARGED MULTIVESICULAR BODY PROTEIN CHARGED MULTIVESICULAR BODY PROTEIN 2B endosomal transport#GO:0016197;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;vacuolar transport#GO:0007034;transport#GO:0006810;intracellular transport#GO:0046907;endosome transport via multivesicular body sorting pathway#GO:0032509;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;multivesicular body sorting pathway#GO:0071985;macromolecule localization#GO:0033036;protein transport#GO:0015031;localization#GO:0051179;cellular localization#GO:0051641;late endosome to vacuole transport#GO:0045324 membrane#GO:0016020;vesicle membrane#GO:0012506;cytoplasm#GO:0005737;late endosome#GO:0005770;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;vesicle#GO:0031982;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;endosome membrane#GO:0010008;endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227 membrane traffic protein#PC00150 HUMAN|HGNC=2447|UniProtKB=P05814 P05814 CSN2 PTHR11500:SF0 BETA CASEIN BETA-CASEIN molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866;enzyme inhibitor activity#GO:0004857;molecular function inhibitor activity#GO:0140678;cysteine-type endopeptidase inhibitor activity#GO:0004869;enzyme regulator activity#GO:0030234;peptidase regulator activity#GO:0061134;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414 establishment of localization#GO:0051234;anatomical structure development#GO:0048856;secretion#GO:0046903;animal organ development#GO:0048513;localization#GO:0051179;regulation of biological quality#GO:0065008;animal gross anatomical part developmental process#GO:0160108;transport#GO:0006810;developmental process#GO:0032502;regulation of body fluid levels#GO:0050878;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 storage protein#PC00210 HUMAN|HGNC=969|UniProtKB=Q96RK4 Q96RK4 BBS4 PTHR44186:SF1 FAMILY NOT NAMED BBSOME COMPLEX MEMBER BBS4 HUMAN|HGNC=7554|UniProtKB=Q99417 Q99417 MYCBP PTHR13168:SF2 ASSOCIATE OF C-MYC AMY-1 C-MYC-BINDING PROTEIN transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;transcription coactivator activity#GO:0003713 regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 PDGF signaling pathway#P00047>c-Myc#P01172 HUMAN|HGNC=34499|UniProtKB=P0DMW4 P0DMW4 SMIM10L2A PTHR34446:SF3 SMALL INTEGRAL MEMBRANE PROTEIN 10 SMALL INTEGRAL MEMBRANE PROTEIN 10-LIKE PROTEIN 2A-RELATED HUMAN|HGNC=13206|UniProtKB=O60296 O60296 TRAK2 PTHR15751:SF13 TRAFFICKING KINESIN-BINDING PROTEIN TRAFFICKING KINESIN-BINDING PROTEIN 2 protein binding#GO:0005515;signaling receptor binding#GO:0005102;myosin binding#GO:0017022;GABA receptor binding#GO:0050811;binding#GO:0005488;cytoskeletal protein binding#GO:0008092 vesicle localization#GO:0051648;multicellular organismal process#GO:0032501;cytoskeleton-dependent intracellular transport#GO:0030705;vesicle transport along microtubule#GO:0047496;intracellular transport#GO:0046907;developmental process#GO:0032502;transport#GO:0006810;transport along microtubule#GO:0010970;cellular developmental process#GO:0048869;establishment of localization#GO:0051234;vesicle cytoskeletal trafficking#GO:0099518;mitochondrion localization#GO:0051646;neurogenesis#GO:0022008;microtubule-based movement#GO:0007018;organelle localization#GO:0051640;localization#GO:0051179;anatomical structure development#GO:0048856;system development#GO:0048731;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;establishment of vesicle localization#GO:0051650;organelle transport along microtubule#GO:0072384;nervous system development#GO:0007399;multicellular organism development#GO:0007275;microtubule-based process#GO:0007017;cell differentiation#GO:0030154;protein targeting#GO:0006605;establishment of organelle localization#GO:0051656;animal gross anatomical part developmental process#GO:0160108;microtubule-based transport#GO:0099111;cellular localization#GO:0051641 intracellular organelle#GO:0043229;dendritic tree#GO:0097447;dendrite#GO:0030425;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;vesicle#GO:0031982;mitochondrion#GO:0005739;intracellular vesicle#GO:0097708;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;neuron projection#GO:0043005;somatodendritic compartment#GO:0036477;cytoplasm#GO:0005737 membrane traffic protein#PC00150 HUMAN|HGNC=10527|UniProtKB=Q9BXA9 Q9BXA9 SALL3 PTHR23233:SF46 SAL-LIKE PROTEIN SAL-LIKE PROTEIN 3 DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA-binding transcription factor#PC00218;C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HUMAN|HGNC=9338|UniProtKB=P02812 P02812 PRB2 PTHR23203:SF20 PROLINE-RICH PROTEIN BASIC SALIVARY PROLINE-RICH PROTEIN 1-RELATED antimicrobial response protein#PC00051 HUMAN|HGNC=9063|UniProtKB=Q15111 Q15111 PLCL1 PTHR10336:SF102 PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 1 hydrolase activity#GO:0016787;lipase activity#GO:0016298;phosphoric ester hydrolase activity#GO:0042578;phosphoric diester hydrolase activity#GO:0008081;glycerophospholipase activity#GO:0004620;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phospholipase activity#GO:0120569 regulation of biological process#GO:0050789;cellular process#GO:0009987;cell-cell signaling#GO:0007267;signaling#GO:0023052;biological regulation#GO:0065007;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;regulation of trans-synaptic signaling#GO:0099177;regulation of cellular process#GO:0050794;regulation of signaling#GO:0023051;cell communication#GO:0007154 lipase#PC00143;phospholipase#PC00186;metabolite interconversion enzyme#PC00262;hydrolase#PC00121 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PLCbetagamma#P00874;Thyrotropin-releasing hormone receptor signaling pathway#P04394>PLC#P04581;5HT2 type receptor mediated signaling pathway#P04374>PLC#P04412;Histamine H1 receptor mediated signaling pathway#P04385>PLC#P04484;Oxytocin receptor mediated signaling pathway#P04391>PLC beta#P04530 HUMAN|HGNC=13374|UniProtKB=Q9H3V2 Q9H3V2 MS4A5 PTHR23320:SF54 MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 5 transporter#PC00227 HUMAN|HGNC=12691|UniProtKB=P15311 P15311 EZR PTHR23281:SF13 MERLIN/MOESIN/EZRIN/RADIXIN EZRIN protein binding#GO:0005515;binding#GO:0005488;cell adhesion molecule binding#GO:0050839;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092 positive regulation of cellular process#GO:0048522;regulation of organelle assembly#GO:1902115;positive regulation of transport#GO:0051050;positive regulation of biological process#GO:0048518;biological regulation#GO:0065007;regulation of localization#GO:0032879;regulation of transport#GO:0051049;regulation of anatomical structure morphogenesis#GO:0022603;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;regulation of cell shape#GO:0008360;regulation of organelle organization#GO:0033043;regulation of developmental process#GO:0050793;regulation of cellular component biogenesis#GO:0044087;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of protein localization#GO:0032880;regulation of biological quality#GO:0065008 intracellular organelle#GO:0043229;filopodium#GO:0030175;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;actin-based cell projection#GO:0098858;microvillus#GO:0005902;actin cytoskeleton#GO:0015629;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;apical part of cell#GO:0045177;cytoskeleton#GO:0005856;adherens junction#GO:0005912;membraneless organelle#GO:0043228;cell junction#GO:0030054;cell periphery#GO:0071944;membrane#GO:0016020;cell-cell junction#GO:0005911;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=19123|UniProtKB=Q8WXX5 Q8WXX5 DNAJC9 PTHR44144:SF1 DNAJ HOMOLOG SUBFAMILY C MEMBER 9 DNAJ HOMOLOG SUBFAMILY C MEMBER 9 heat shock protein binding#GO:0031072;binding#GO:0005488;protein binding#GO:0005515 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 chaperone#PC00072 HUMAN|HGNC=17617|UniProtKB=Q96LA9 Q96LA9 MRGPRX4 PTHR11334:SF59 MAS-RELATED G-PROTEIN COUPLED RECEPTOR MAS-RELATED G PROTEIN-COUPLED RECEPTOR MEMBER X4 signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=29219|UniProtKB=Q6ZU35 Q6ZU35 CRACD PTHR47574:SF3 CANCER-RELATED REGULATOR OF ACTIN DYNAMICS CAPPING PROTEIN-INHIBITING REGULATOR OF ACTIN DYNAMICS regulation of actin filament length#GO:0030832;positive regulation of cellular component organization#GO:0051130;positive regulation of organelle organization#GO:0010638;regulation of biological quality#GO:0065008;regulation of protein-containing complex assembly#GO:0043254;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of cellular component size#GO:0032535;regulation of cellular component organization#GO:0051128;regulation of cellular component biogenesis#GO:0044087;regulation of anatomical structure size#GO:0090066;cellular component organization or biogenesis#GO:0071840;regulation of protein-containing complex disassembly#GO:0043244;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;anatomical structure homeostasis#GO:0060249;positive regulation of cellular component biogenesis#GO:0044089;regulation of actin cytoskeleton organization#GO:0032956;epithelial structure maintenance#GO:0010669;tissue homeostasis#GO:0001894;negative regulation of cellular component organization#GO:0051129;regulation of supramolecular fiber organization#GO:1902903;regulation of cellular process#GO:0050794;regulation of cytoskeleton organization#GO:0051493;regulation of protein polymerization#GO:0032271;regulation of actin filament depolymerization#GO:0030834;homeostatic process#GO:0042592;regulation of actin filament-based process#GO:0032970;negative regulation of cellular process#GO:0048523;multicellular organismal-level homeostasis#GO:0048871;regulation of protein depolymerization#GO:1901879;system process#GO:0003008;regulation of actin filament organization#GO:0110053;positive regulation of cellular process#GO:0048522;multicellular organismal process#GO:0032501;digestion#GO:0007586;regulation of actin filament polymerization#GO:0030833;positive regulation of protein polymerization#GO:0032273;regulation of actin polymerization or depolymerization#GO:0008064;biological regulation#GO:0065007 HUMAN|HGNC=24211|UniProtKB=Q5GAN4 Q5GAN4 RNASE12 PTHR11437:SF20 RIBONUCLEASE INACTIVE RIBONUCLEASE-LIKE PROTEIN 12-RELATED catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;nuclease activity#GO:0004518;RNA nuclease activity#GO:0004540;catalytic activity, acting on RNA#GO:0140098 response to bacterium#GO:0009617;defense response to bacterium#GO:0042742;response to external stimulus#GO:0009605;defense response#GO:0006952;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;defense response to Gram-positive bacterium#GO:0050830;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to other organism#GO:0051707 endoribonuclease#PC00094;RNA metabolism protein#PC00031 HUMAN|HGNC=24736|UniProtKB=P0C875 P0C875 FAM228B PTHR28584:SF3 FAMILY WITH SEQUENCE SIMILARITY 228 MEMBER A PROTEIN FAM228B HUMAN|HGNC=5116|UniProtKB=P09067 P09067 HOXB5 PTHR45659:SF2 HOMEOBOX PROTEIN HOX HOMEOBOX PROTEIN HOX-B5 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regionalization#GO:0003002;multicellular organismal process#GO:0032501;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;multicellular organism development#GO:0007275;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;anterior/posterior pattern specification#GO:0009952;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;pattern specification process#GO:0007389 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 HUMAN|HGNC=14596|UniProtKB=Q96QG7 Q96QG7 MTMR9 PTHR10807:SF56 MYOTUBULARIN-RELATED MYOTUBULARIN-RELATED PROTEIN 9 phosphoric ester hydrolase activity#GO:0042578;protein phosphatase binding#GO:0019903;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;protein binding#GO:0005515;hydrolase activity#GO:0016787;phosphatase binding#GO:0019902;binding#GO:0005488;enzyme binding#GO:0019899 biological regulation#GO:0065007;glycerophospholipid metabolic process#GO:0006650;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;regulation of metabolic process#GO:0019222;negative regulation of autophagy#GO:0010507;regulation of catabolic process#GO:0009894;lipid modification#GO:0030258;phosphatidylinositol metabolic process#GO:0046488;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;negative regulation of cellular process#GO:0048523;phospholipid metabolic process#GO:0006644;negative regulation of metabolic process#GO:0009892;glycerolipid metabolic process#GO:0046486;regulation of cellular process#GO:0050794;phospholipid dephosphorylation#GO:0046839;regulation of biological process#GO:0050789;phosphate-containing compound metabolic process#GO:0006796;negative regulation of biological process#GO:0048519;regulation of autophagy#GO:0010506;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;negative regulation of catabolic process#GO:0009895;dephosphorylation#GO:0016311;phosphatidylinositol dephosphorylation#GO:0046856 membrane#GO:0016020;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 phosphatase#PC00181 HUMAN|HGNC=25363|UniProtKB=Q9H0R3 Q9H0R3 TMEM222 PTHR20921:SF0 TRANSMEMBRANE PROTEIN 222 TRANSMEMBRANE PROTEIN 222 HUMAN|HGNC=34303|UniProtKB=Q6ZNQ3 Q6ZNQ3 LRRC69 PTHR45752:SF1 LEUCINE-RICH REPEAT-CONTAINING LEUCINE-RICH REPEAT-CONTAINING PROTEIN 69 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 scaffold/adaptor protein#PC00226 HUMAN|HGNC=537|UniProtKB=P07355 P07355 ANXA2 PTHR10502:SF18 ANNEXIN ANNEXIN A2-RELATED anion binding#GO:0043168;small molecule binding#GO:0036094;binding#GO:0005488;phospholipid binding#GO:0005543;ion binding#GO:0043167;lipid binding#GO:0008289;phosphatidylserine binding#GO:0001786 cell adhesion#GO:0007155;positive regulation of protein metabolic process#GO:0051247;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of proteolysis#GO:0030162;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;positive regulation of macromolecule metabolic process#GO:0010604 membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;vesicle membrane#GO:0012506;membrane#GO:0016020;vesicle#GO:0031982;nucleus#GO:0005634;cell periphery#GO:0071944 calcium-binding protein#PC00060 HUMAN|HGNC=4181|UniProtKB=Q92538 Q92538 GBF1 PTHR10663:SF412 GUANYL-NUCLEOTIDE EXCHANGE FACTOR GOLGI-SPECIFIC BREFELDIN A-RESISTANCE GUANINE NUCLEOTIDE EXCHANGE FACTOR 1 endomembrane system organization#GO:0010256;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;Golgi organization#GO:0007030;cellular component organization#GO:0016043;organelle organization#GO:0006996;establishment of localization#GO:0051234;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;transport#GO:0006810;Golgi vesicle transport#GO:0048193 organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;organelle#GO:0043226;Golgi cisterna#GO:0031985;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;Golgi cis cisterna#GO:0000137;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus subcompartment#GO:0098791;Golgi stack#GO:0005795 guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=10302|UniProtKB=P30050 P30050 RPL12 PTHR11661:SF21 60S RIBOSOMAL PROTEIN L12 LARGE RIBOSOMAL SUBUNIT PROTEIN UL11 binding#GO:0005488;rRNA binding#GO:0019843;nucleic acid binding#GO:0003676;structural constituent of ribosome#GO:0003735;RNA binding#GO:0003723;structural molecule activity#GO:0005198 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;translation#GO:0006412;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 cytosol#GO:0005829;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625;ribosome#GO:0005840;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202 HUMAN|HGNC=8154|UniProtKB=P41145 P41145 OPRK1 PTHR24229:SF1 NEUROPEPTIDES RECEPTOR KAPPA-TYPE OPIOID RECEPTOR binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;peptide binding#GO:0042277;neuropeptide binding#GO:0042923;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023 neuropeptide signaling pathway#GO:0007218;sensory perception of pain#GO:0019233;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;G protein-coupled receptor signaling pathway#GO:0007186;nervous system process#GO:0050877;sensory perception#GO:0007600;cell communication#GO:0007154;cellular process#GO:0009987;signal transduction#GO:0007165;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;system process#GO:0003008 membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane#GO:0005886;plasma membrane bounded cell projection#GO:0120025 G-protein coupled receptor#PC00021 Opioid prodynorphin pathway#P05916>Kappa Receptor#P05998;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GoPCR#P00725 HUMAN|HGNC=12874|UniProtKB=O60481 O60481 ZIC3 PTHR19818:SF175 ZINC FINGER PROTEIN ZIC AND GLI ZINC FINGER PROTEIN ZIC 3 DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of DNA-templated transcription#GO:0045893;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;central nervous system development#GO:0007417;animal gross anatomical part developmental process#GO:0160108;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604;nervous system development#GO:0007399;positive regulation of transcription by RNA polymerase II#GO:0045944;multicellular organism development#GO:0007275 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=24765|UniProtKB=Q6PCB5 Q6PCB5 RSBN1L PTHR13354:SF9 ROUND SPERMATID BASIC PROTEIN 1 LYSINE-SPECIFIC DEMETHYLASE RSBN1L dioxygenase activity#GO:0051213;histone modifying activity#GO:0140993;catalytic activity#GO:0003824;histone demethylase activity#GO:0032452;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;protein demethylase activity#GO:0140457;catalytic activity, acting on a protein#GO:0140096;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;oxidoreductase activity#GO:0016491;demethylase activity#GO:0032451 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=30045|UniProtKB=Q96Q15 Q96Q15 SMG1 PTHR11139:SF71 ATAXIA TELANGIECTASIA MUTATED ATM -RELATED SERINE_THREONINE-PROTEIN KINASE SMG1 catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674 RNA metabolic process#GO:0016070;RNA catabolic process#GO:0006401;cellular response to stress#GO:0033554;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay#GO:0000184;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;cellular process#GO:0009987;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;response to stress#GO:0006950;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;DNA damage response#GO:0006974;negative regulation of cellular process#GO:0048523;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;negative regulation of macromolecule metabolic process#GO:0010605;nucleic acid catabolic process#GO:0141188;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=21576|UniProtKB=Q6VVB1 Q6VVB1 NHLRC1 PTHR24104:SF64 E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED E3 UBIQUITIN-PROTEIN LIGASE NHLRC1 transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842 cellular process#GO:0009987;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;proteasomal protein catabolic process#GO:0010498;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;protein modification process#GO:0036211;catabolic process#GO:0009056;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein modification by small protein conjugation or removal#GO:0070647;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=28539|UniProtKB=Q8IYV9 Q8IYV9 IZUMO1 PTHR35540:SF1 IZUMO SPERM-EGG FUSION PROTEIN 1 IZUMO SPERM-EGG FUSION PROTEIN 1 protein binding#GO:0005515;molecular function activator activity#GO:0140677;binding#GO:0005488;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;cell-cell adhesion mediator activity#GO:0098632;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;cell adhesion mediator activity#GO:0098631;cell adhesion molecule binding#GO:0050839 reproductive process#GO:0022414;cellular process involved in reproduction in multicellular organism#GO:0022412;fertilization#GO:0009566;cellular process#GO:0009987;fusion of sperm to egg plasma membrane involved in single fertilization#GO:0007342;single fertilization#GO:0007338;multicellular organismal reproductive process#GO:0048609;cell-cell recognition#GO:0009988;binding of sperm to zona pellucida#GO:0007339;cell recognition#GO:0008037;sexual reproduction#GO:0019953;sperm-egg recognition#GO:0035036 acrosomal membrane#GO:0002080;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane#GO:0016020;secretory vesicle#GO:0099503;vesicle membrane#GO:0012506;cell periphery#GO:0071944;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;plasma membrane#GO:0005886;acrosomal vesicle#GO:0001669;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;intracellular vesicle#GO:0097708;secretory granule membrane#GO:0030667;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=11828|UniProtKB=Q9UDY2 Q9UDY2 TJP2 PTHR13865:SF26 TIGHT JUNCTION PROTEIN TIGHT JUNCTION PROTEIN 2 protein binding#GO:0005515;binding#GO:0005488;cell adhesion molecule binding#GO:0050839 cellular process#GO:0009987;cell-cell adhesion#GO:0098609;macromolecule localization#GO:0033036;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;tissue development#GO:0009888;anatomical structure homeostasis#GO:0060249;epithelial cell differentiation#GO:0030855;blood circulation#GO:0008015;epithelium development#GO:0060429;endothelial cell differentiation#GO:0045446;developmental process#GO:0032502;cell-cell junction organization#GO:0045216;multicellular organismal-level homeostasis#GO:0048871;system process#GO:0003008;intracellular protein localization#GO:0008104;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;cell development#GO:0048468;homeostatic process#GO:0042592;cell junction organization#GO:0034330;cell differentiation#GO:0030154;cell adhesion#GO:0007155;circulatory system process#GO:0003013;animal gross anatomical part developmental process#GO:0160108;protein localization to cell junction#GO:1902414;regulation of biological quality#GO:0065008;tissue homeostasis#GO:0001894;anatomical structure development#GO:0048856;localization#GO:0051179 membrane#GO:0016020;cell-cell junction#GO:0005911;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;bicellular tight junction#GO:0005923;plasma membrane#GO:0005886;apical junction complex#GO:0043296;tight junction#GO:0070160;cell junction#GO:0030054;anchoring junction#GO:0070161 tight junction#PC00214;cell junction protein#PC00070 HUMAN|HGNC=24148|UniProtKB=Q6AWC2 Q6AWC2 WWC2 PTHR14791:SF26 BOMB/KIRA PROTEINS PROTEIN WWC2 binding#GO:0005488;kinase binding#GO:0019900;enzyme binding#GO:0019899;protein binding#GO:0005515 negative regulation of biological process#GO:0048519;negative regulation of multicellular organismal process#GO:0051241;regulation of growth#GO:0040008;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;cell motility#GO:0048870;regulation of cellular process#GO:0050794;regulation of developmental process#GO:0050793;regulation of hippo signaling#GO:0035330;regulation of cell communication#GO:0010646;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;cell migration#GO:0016477;regulation of signal transduction#GO:0009966;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of multicellular organismal process#GO:0051239;regulation of response to stimulus#GO:0048583;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=16979|UniProtKB=Q92496 Q92496 CFHR4 PTHR45785:SF4 COMPLEMENT FACTOR H-RELATED COMPLEMENT FACTOR H-RELATED PROTEIN 3-RELATED complement binding#GO:0001848;binding#GO:0005488;protein binding#GO:0005515 regulation of immune system process#GO:0002682;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;immune system process#GO:0002376;regulation of immune response#GO:0050776;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;positive regulation of immune system process#GO:0002684;complement activation#GO:0006956;activation of immune response#GO:0002253;positive regulation of biological process#GO:0048518;immune response#GO:0006955;humoral immune response#GO:0006959;regulation of response to stimulus#GO:0048583;immune effector process#GO:0002252;positive regulation of immune response#GO:0050778 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 complement component#PC00078 HUMAN|HGNC=6128|UniProtKB=O14654 O14654 IRS4 PTHR10614:SF2 INSULIN RECEPTOR SUBSTRATE INSULIN RECEPTOR SUBSTRATE 4 receptor tyrosine kinase binding#GO:0030971;molecular adaptor activity#GO:0060090;signaling receptor complex adaptor activity#GO:0030159;protein kinase binding#GO:0019901;transmembrane receptor protein tyrosine kinase adaptor activity#GO:0005068;enzyme binding#GO:0019899;protein-macromolecule adaptor activity#GO:0030674;protein tyrosine kinase binding#GO:1990782;kinase binding#GO:0019900;binding#GO:0005488;signaling receptor binding#GO:0005102;protein binding#GO:0005515;signaling adaptor activity#GO:0035591 response to hormone#GO:0009725;cellular process#GO:0009987;signal transduction#GO:0007165;phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0043491;cellular response to oxygen-containing compound#GO:1901701;cellular response to nitrogen compound#GO:1901699;response to chemical#GO:0042221;intracellular signaling cassette#GO:0141124;response to peptide hormone#GO:0043434;biological regulation#GO:0065007;cell surface receptor signaling pathway#GO:0007166;cellular response to insulin stimulus#GO:0032869;response to endogenous stimulus#GO:0009719;response to insulin#GO:0032868;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;cellular response to hormone stimulus#GO:0032870;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;insulin-like growth factor receptor signaling pathway#GO:0048009;cellular response to peptide hormone stimulus#GO:0071375;signaling#GO:0023052;cellular response to chemical stimulus#GO:0070887;insulin receptor signaling pathway#GO:0008286;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;response to oxygen-containing compound#GO:1901700;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;response to nitrogen compound#GO:1901698 plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;cytosol#GO:0005829;membrane#GO:0016020 scaffold/adaptor protein#PC00226 Gonadotropin-releasing hormone receptor pathway#P06664>IRS#P06759;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>IRS 1-4#P00887;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>IRS 1-4#P00899 HUMAN|HGNC=24036|UniProtKB=O95996 O95996 APC2 PTHR12607:SF3 ADENOMATOUS POLYPOSIS COLI PROTEIN FAMILY ADENOMATOUS POLYPOSIS COLI PROTEIN 2 beta-catenin binding#GO:0008013;protein binding#GO:0005515;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;microtubule binding#GO:0008017 cell fate commitment#GO:0045165;negative regulation of cell communication#GO:0010648;regulation of signaling#GO:0023051;negative regulation of canonical Wnt signaling pathway#GO:0090090;negative regulation of signaling#GO:0023057;animal gross anatomical part developmental process#GO:0160108;regulation of Wnt signaling pathway#GO:0030111;cell differentiation#GO:0030154;regulation of cellular component organization#GO:0051128;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;negative regulation of biological process#GO:0048519;multicellular organism development#GO:0007275;cell fate specification#GO:0001708;negative regulation of signal transduction#GO:0009968;regulation of microtubule cytoskeleton organization#GO:0070507;nervous system development#GO:0007399;cellular process#GO:0009987;regulation of protein-containing complex disassembly#GO:0043244;regulation of canonical Wnt signaling pathway#GO:0060828;system development#GO:0048731;negative regulation of cytoskeleton organization#GO:0051494;anatomical structure development#GO:0048856;negative regulation of protein-containing complex disassembly#GO:0043242;pattern specification process#GO:0007389;regulation of microtubule-based process#GO:0032886;regulation of cell communication#GO:0010646;negative regulation of supramolecular fiber organization#GO:1902904;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794;cell motility#GO:0048870;regulation of supramolecular fiber organization#GO:1902903;negative regulation of organelle organization#GO:0010639;negative regulation of cellular component organization#GO:0051129;regulation of microtubule polymerization or depolymerization#GO:0031110;regulation of protein depolymerization#GO:1901879;cellular developmental process#GO:0048869;developmental process#GO:0032502;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of protein depolymerization#GO:1901880;negative regulation of response to stimulus#GO:0048585;cell migration#GO:0016477;multicellular organismal process#GO:0032501;negative regulation of Wnt signaling pathway#GO:0030178 cytoskeleton#GO:0005856;extrinsic component of membrane#GO:0019898;extrinsic component of plasma membrane#GO:0019897;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;intracellular protein-containing complex#GO:0140535;microtubule cytoskeleton#GO:0015630;membrane#GO:0016020;cell periphery#GO:0071944;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;microtubule#GO:0005874;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;membrane protein complex#GO:0098796;cytoplasmic microtubule#GO:0005881;plasma membrane protein complex#GO:0098797;organelle#GO:0043226;cellular anatomical structure#GO:0110165 Wnt signaling pathway#P00057>APC#P01468;Angiogenesis#P00005>APC#P00195 HUMAN|HGNC=8378|UniProtKB=Q96RA2 Q96RA2 OR7D2 PTHR48001:SF107 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 7D2 transmembrane signal receptor#PC00197 HUMAN|HGNC=29517|UniProtKB=Q96C10 Q96C10 DHX58 PTHR14074:SF7 HELICASE WITH DEATH DOMAIN-RELATED ATP-DEPENDENT RNA HELICASE DHX58 single-stranded RNA binding#GO:0003727;zinc ion binding#GO:0008270;metal ion binding#GO:0046872;RNA binding#GO:0003723;cation binding#GO:0043169;small molecule binding#GO:0036094;binding#GO:0005488;nucleic acid binding#GO:0003676;ion binding#GO:0043167;transition metal ion binding#GO:0046914;double-stranded RNA binding#GO:0003725 regulation of response to external stimulus#GO:0032101;defense response to other organism#GO:0098542;negative regulation of signal transduction#GO:0009968;response to biotic stimulus#GO:0009607;positive regulation of immune system process#GO:0002684;response to stress#GO:0006950;positive regulation of biological process#GO:0048518;defense response to symbiont#GO:0140546;signal transduction#GO:0007165;activation of immune response#GO:0002253;cellular process#GO:0009987;immune response-activating signaling pathway#GO:0002757;positive regulation of response to external stimulus#GO:0032103;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052;negative regulation of biological process#GO:0048519;defense response to virus#GO:0051607;regulation of biological process#GO:0050789;immune response-regulating signaling pathway#GO:0002764;cytoplasmic pattern recognition receptor signaling pathway#GO:0002753;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;immune system process#GO:0002376;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;positive regulation of response to stimulus#GO:0048584;negative regulation of response to stimulus#GO:0048585;biological regulation#GO:0065007;negative regulation of immune system process#GO:0002683;regulation of signal transduction#GO:0009966;response to other organism#GO:0051707;activation of innate immune response#GO:0002218;immune response#GO:0006955;positive regulation of innate immune response#GO:0045089;regulation of innate immune response#GO:0045088;innate immune response#GO:0045087;positive regulation of response to biotic stimulus#GO:0002833;response to external stimulus#GO:0009605;pattern recognition receptor signaling pathway#GO:0002221;defense response#GO:0006952;negative regulation of cellular process#GO:0048523;regulation of response to stress#GO:0080134;positive regulation of defense response#GO:0031349;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;intracellular receptor signaling pathway#GO:0030522;response to external biotic stimulus#GO:0043207;regulation of cell communication#GO:0010646;regulation of response to biotic stimulus#GO:0002831;innate immune response-activating signaling pathway#GO:0002758;antiviral innate immune response#GO:0140374;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;response to virus#GO:0009615;intracellular signal transduction#GO:0035556;regulation of immune response#GO:0050776;regulation of defense response#GO:0031347 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=4658|UniProtKB=Q92759 Q92759 GTF2H4 PTHR13152:SF0 TFIIH, POLYPEPTIDE 4 GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4 RNA metabolic process#GO:0016070;cellular response to stress#GO:0033554;nucleic acid biosynthetic process#GO:0141187;DNA-templated transcription initiation#GO:0006352;response to stimulus#GO:0050896;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;DNA metabolic process#GO:0006259;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;DNA repair#GO:0006281;transcription by RNA polymerase II#GO:0006366;DNA damage response#GO:0006974;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;nucleotide-excision repair#GO:0006289;response to stress#GO:0006950;transcription initiation at RNA polymerase II promoter#GO:0006367;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 membrane-enclosed lumen#GO:0031974;RNA polymerase II transcription regulator complex#GO:0090575;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;protein-containing complex#GO:0032991;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;transcription factor TFIIH core complex#GO:0000439;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;transcription regulator complex#GO:0005667;intracellular protein-containing complex#GO:0140535;protein kinase complex#GO:1902911;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;transcription factor TFIIH holo complex#GO:0005675;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;RNA polymerase II, holoenzyme#GO:0016591;membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622 general transcription factor#PC00259;RNA metabolism protein#PC00031 General transcription regulation#P00023>TFIIH complex#P00664;Transcription regulation by bZIP transcription factor#P00055>TFIIH complex#P01392 HUMAN|HGNC=17839|UniProtKB=Q8NHZ8 Q8NHZ8 CDC26 PTHR28579:SF1 ANAPHASE-PROMOTING COMPLEX SUBUNIT CDC26 ANAPHASE-PROMOTING COMPLEX SUBUNIT CDC26 regulation of cell cycle#GO:0051726;regulation of cellular process#GO:0050794;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;regulation of biological process#GO:0050789;protein K11-linked ubiquitination#GO:0070979;protein modification process#GO:0036211;primary metabolic process#GO:0044238;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein modification by small protein conjugation or removal#GO:0070647;protein ubiquitination#GO:0016567;biological regulation#GO:0065007;post-translational protein modification#GO:0043687;cellular process#GO:0009987;regulation of mitotic cell cycle#GO:0007346;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152 nucleus#GO:0005634;anaphase-promoting complex#GO:0005680;protein-containing complex#GO:0032991;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular membrane-bounded organelle#GO:0043231;nuclear ubiquitin ligase complex#GO:0000152;organelle#GO:0043226;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ubiquitin ligase complex#GO:0000151 HUMAN|HGNC=10571|UniProtKB=O00767 O00767 SCD PTHR11351:SF102 ACYL-COA DESATURASE STEAROYL-COA DESATURASE oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824;iron ion binding#GO:0005506;oxidoreductase activity#GO:0016491;transition metal ion binding#GO:0046914;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;cation binding#GO:0043169;metal ion binding#GO:0046872 unsaturated fatty acid metabolic process#GO:0033559;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;monocarboxylic acid biosynthetic process#GO:0072330;cellular process#GO:0009987;fatty acid biosynthetic process#GO:0006633;biosynthetic process#GO:0009058;unsaturated fatty acid biosynthetic process#GO:0006636;lipid biosynthetic process#GO:0008610;oxoacid metabolic process#GO:0043436;carboxylic acid biosynthetic process#GO:0046394;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;small molecule metabolic process#GO:0044281 organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;endoplasmic reticulum membrane#GO:0005789;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783 HUMAN|HGNC=26576|UniProtKB=Q8NBH2 Q8NBH2 KY PTHR46333:SF3 CYTOKINESIS PROTEIN 3 KYPHOSCOLIOSIS PEPTIDASE muscle organ development#GO:0007517;animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502;synapse organization#GO:0050808;cellular component organization or biogenesis#GO:0071840;animal organ development#GO:0048513;anatomical structure development#GO:0048856;neuromuscular junction development#GO:0007528;cellular component organization#GO:0016043;cellular process#GO:0009987;muscle structure development#GO:0061061;cell junction organization#GO:0034330 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=15624|UniProtKB=Q96JL9 Q96JL9 ZNF333 PTHR24377:SF1038 IP01015P-RELATED ZINC FINGER PROTEIN 333 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=6470|UniProtKB=P32004 P32004 L1CAM PTHR45080:SF15 CONTACTIN 5 NEURAL CELL ADHESION MOLECULE L1 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cell adhesion#GO:0007155;synapse organization#GO:0050808;cellular component organization or biogenesis#GO:0071840;homophilic cell-cell adhesion#GO:0007156;cellular component organization#GO:0016043;cell-cell adhesion#GO:0098609;cellular process#GO:0009987;cell junction organization#GO:0034330 axon#GO:0030424;cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;neuronal cell body#GO:0043025;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005;cell body#GO:0044297 HUMAN|HGNC=16986|UniProtKB=Q12907 Q12907 LMAN2 PTHR12223:SF36 VESICULAR MANNOSE-BINDING LECTIN VESICULAR INTEGRAL-MEMBRANE PROTEIN VIP36 binding#GO:0005488;small molecule binding#GO:0036094;carbohydrate binding#GO:0030246;monosaccharide binding#GO:0048029 establishment of localization in cell#GO:0051649;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;transport#GO:0006810;Golgi vesicle transport#GO:0048193;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888 Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane#GO:0016020;endomembrane system#GO:0012505;cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;COPII-coated ER to Golgi transport vesicle#GO:0030134;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;coated vesicle#GO:0030135;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular vesicle#GO:0097708;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;vesicle#GO:0031982;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 membrane traffic protein#PC00150 HUMAN|HGNC=33766|UniProtKB=Q6ZRC1 Q6ZRC1 C4orf50 PTHR36866:SF1 CHROMOSOME 4 OPEN READING FRAME 50 GENE 1043-RELATED HUMAN|HGNC=1643|UniProtKB=P20273 P20273 CD22 PTHR46958:SF1 B-CELL RECEPTOR CD22 B-CELL RECEPTOR CD22 carbohydrate derivative binding#GO:0097367;protein phosphatase binding#GO:0019903;organic acid binding#GO:0043177;enzyme binding#GO:0019899;signaling receptor binding#GO:0005102;binding#GO:0005488;anion binding#GO:0043168;carboxylic acid binding#GO:0031406;small molecule binding#GO:0036094;phosphatase binding#GO:0019902;ion binding#GO:0043167;protein binding#GO:0005515 negative regulation of cell communication#GO:0010648;regulation of signaling#GO:0023051;immune system process#GO:0002376;negative regulation of signaling#GO:0023057;regulation of lymphocyte activation#GO:0051249;regulation of biological process#GO:0050789;regulation of cell activation#GO:0050865;regulation of leukocyte activation#GO:0002694;negative regulation of biological process#GO:0048519;B cell activation#GO:0042113;regulation of leukocyte proliferation#GO:0070663;regulation of B cell proliferation#GO:0030888;regulation of multicellular organismal process#GO:0051239;negative regulation of signal transduction#GO:0009968;lymphocyte activation#GO:0046649;cellular process#GO:0009987;regulation of B cell activation#GO:0050864;regulation of mononuclear cell proliferation#GO:0032944;regulation of cell population proliferation#GO:0042127;regulation of immune response#GO:0050776;cell activation#GO:0001775;regulation of B cell receptor signaling pathway#GO:0050855;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;leukocyte activation#GO:0045321;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;negative regulation of immune system process#GO:0002683;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regulation of lymphocyte proliferation#GO:0050670;negative regulation of response to stimulus#GO:0048585 recycling endosome#GO:0055037;cell surface#GO:0009986;endomembrane system#GO:0012505;plasma membrane#GO:0005886;cytoplasm#GO:0005737;membrane#GO:0016020;cell periphery#GO:0071944;side of membrane#GO:0098552;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;external side of plasma membrane#GO:0009897;endosome#GO:0005768;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982 B cell activation#P00010>CD22#P00387 HUMAN|HGNC=16955|UniProtKB=Q99501 Q99501 GAS2L1 PTHR46756:SF16 TRANSGELIN GAS2-LIKE PROTEIN 1 binding#GO:0005488;actin filament binding#GO:0051015;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877 cellular component organization or biogenesis#GO:0071840;intracellular protein localization#GO:0008104;actin filament organization#GO:0007015;microtubule-based process#GO:0007017;regulation of microtubule polymerization or depolymerization#GO:0031110;macromolecule localization#GO:0033036;organelle organization#GO:0006996;cellular process#GO:0009987;protein localization to microtubule cytoskeleton#GO:0072698;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;regulation of microtubule cytoskeleton organization#GO:0070507;regulation of microtubule-based process#GO:0032886;actin filament-based process#GO:0030029;microtubule bundle formation#GO:0001578;localization#GO:0051179;microtubule cytoskeleton organization#GO:0000226;supramolecular fiber organization#GO:0097435;cellular component organization#GO:0016043;protein localization to cytoskeleton#GO:0044380;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;protein localization to organelle#GO:0033365 microtubule end#GO:1990752;actin cytoskeleton#GO:0015629;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;actin filament bundle#GO:0032432;actomyosin#GO:0042641;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;stress fiber#GO:0001725;cytoskeleton#GO:0005856;microtubule plus-end#GO:0035371;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228 cytoskeletal protein#PC00085 HUMAN|HGNC=19194|UniProtKB=Q96RW7 Q96RW7 HMCN1 PTHR23277:SF107 NECTIN-RELATED HEMICENTIN-1 protein binding#GO:0005515;cell adhesion mediator activity#GO:0098631;cell adhesion molecule binding#GO:0050839;binding#GO:0005488 cell-cell adhesion#GO:0098609;homophilic cell-cell adhesion#GO:0007156;cellular process#GO:0009987;heterophilic cell-cell adhesion#GO:0007157;cell adhesion#GO:0007155 cell periphery#GO:0071944;membrane#GO:0016020;extracellular matrix#GO:0031012;cell-cell junction#GO:0005911;external encapsulating structure#GO:0030312;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;anchoring junction#GO:0070161;adherens junction#GO:0005912;cell junction#GO:0030054 cell adhesion molecule#PC00069 HUMAN|HGNC=10728|UniProtKB=Q13275 Q13275 SEMA3F PTHR11036:SF27 SEMAPHORIN SEMAPHORIN-3F binding#GO:0005488;signaling receptor binding#GO:0005102;molecular function activator activity#GO:0140677;protein binding#GO:0005515;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546 cellular response to stimulus#GO:0051716;locomotion#GO:0040011;regulation of cellular process#GO:0050794;cell motility#GO:0048870;chemotaxis#GO:0006935;stem cell development#GO:0048864;system development#GO:0048731;regulation of cell motility#GO:2000145;cell communication#GO:0007154;anatomical structure development#GO:0048856;positive regulation of cellular process#GO:0048522;positive regulation of cell migration#GO:0030335;axon development#GO:0061564;axon guidance#GO:0007411;stem cell differentiation#GO:0048863;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;regulation of locomotion#GO:0040012;cell migration#GO:0016477;neural crest cell development#GO:0014032;tissue development#GO:0009888;multicellular organismal process#GO:0032501;developmental process#GO:0032502;regulation of cell migration#GO:0030334;neuron projection morphogenesis#GO:0048812;response to external stimulus#GO:0009605;neuron projection guidance#GO:0097485;positive regulation of locomotion#GO:0040017;neurogenesis#GO:0022008;mesenchyme development#GO:0060485;cellular developmental process#GO:0048869;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;positive regulation of cell motility#GO:2000147;cellular component organization#GO:0016043;signaling#GO:0023052;cell development#GO:0048468;response to stimulus#GO:0050896;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell morphogenesis#GO:0000902;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;neuron development#GO:0048666;axonogenesis#GO:0007409;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;neural crest cell migration#GO:0001755;cellular process#GO:0009987;neuron projection development#GO:0031175;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;response to chemical#GO:0042221;taxis#GO:0042330;neuron differentiation#GO:0030182;neural crest cell differentiation#GO:0014033;cell surface receptor signaling pathway#GO:0007166;plasma membrane bounded cell projection morphogenesis#GO:0120039;mesenchymal cell differentiation#GO:0048762;cell projection morphogenesis#GO:0048858;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;animal organ development#GO:0048513 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 membrane-bound signaling molecule#PC00152 HUMAN|HGNC=9356|UniProtKB=Q9HCU5 Q9HCU5 PREB PTHR23284:SF0 PROLACTIN REGULATORY ELEMENT BINDING PROTEIN GUANINE NUCLEOTIDE-EXCHANGE FACTOR SEC12 establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;membrane organization#GO:0061024;cellular component assembly#GO:0022607;vesicle-mediated transport#GO:0016192;transport#GO:0006810;Golgi vesicle transport#GO:0048193;intracellular transport#GO:0046907;protein-containing complex organization#GO:0043933;vesicle budding from membrane#GO:0006900;vesicle organization#GO:0016050;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;COPII-coated vesicle budding#GO:0090114;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;localization#GO:0051179;cellular localization#GO:0051641 organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;membrane#GO:0016020 guanyl-nucleotide exchange factor#PC00113;protein-binding activity modulator#PC00095 HUMAN|HGNC=2523|UniProtKB=Q99895 Q99895 CTRC PTHR24250:SF35 CHYMOTRYPSIN-RELATED CHYMOTRYPSIN-C catalytic activity#GO:0003824;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;serine-type peptidase activity#GO:0008236;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787 cellular process#GO:0009987;primary metabolic process#GO:0044238;metabolic process#GO:0008152;proteolysis#GO:0006508;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 protein modifying enzyme#PC00260;serine protease#PC00203 HUMAN|HGNC=15995|UniProtKB=Q86WD7 Q86WD7 SERPINA9 PTHR11461:SF40 SERINE PROTEASE INHIBITOR, SERPIN SERPIN A9 peptidase regulator activity#GO:0061134;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;serine-type endopeptidase inhibitor activity#GO:0004867;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;enzyme inhibitor activity#GO:0004857;molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease inhibitor#PC00191 HUMAN|HGNC=30991|UniProtKB=Q6UXM1 Q6UXM1 LRIG3 PTHR24373:SF311 SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 3 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 sensory perception of sound#GO:0007605;multicellular organismal process#GO:0032501;system process#GO:0003008;sensory perception of mechanical stimulus#GO:0050954;sensory perception#GO:0007600;nervous system process#GO:0050877 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=14291|UniProtKB=Q8N2Q7 Q8N2Q7 NLGN1 PTHR43903:SF2 NEUROLIGIN NEUROLIGIN-1 cell junction#GO:0030054;synaptic membrane#GO:0097060;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;cell periphery#GO:0071944;membrane#GO:0016020;postsynapse#GO:0098794 cell adhesion molecule#PC00069 HUMAN|HGNC=26270|UniProtKB=Q9H5I5 Q9H5I5 PIEZO2 PTHR13167:SF24 PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL COMPONENT PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL COMPONENT 2 passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic cation channel activity#GO:0005261;gated channel activity#GO:0022836;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324 detection of mechanical stimulus#GO:0050982;regulation of biological quality#GO:0065008;response to external stimulus#GO:0009605;cellular response to abiotic stimulus#GO:0071214;regulation of membrane potential#GO:0042391;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to mechanical stimulus#GO:0009612;response to abiotic stimulus#GO:0009628;detection of stimulus#GO:0051606;biological regulation#GO:0065007;cellular response to environmental stimulus#GO:0104004;response to stimulus#GO:0050896 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HUMAN|HGNC=30546|UniProtKB=Q6P4F2 Q6P4F2 FDX2 PTHR23426:SF78 FERREDOXIN/ADRENODOXIN FERREDOXIN-2, MITOCHONDRIAL generation of precursor metabolites and energy#GO:0006091;cellular process#GO:0009987;metabolic process#GO:0008152;electron transport chain#GO:0022900 mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 oxidoreductase#PC00176 Vitamin D metabolism and pathway#P04396>FDX#P04607 HUMAN|HGNC=21000|UniProtKB=Q4VC12 Q4VC12 MSS51 PTHR46920:SF1 FAMILY NOT NAMED PROTEIN MSS51 HOMOLOG, MITOCHONDRIAL-RELATED HUMAN|HGNC=2631|UniProtKB=P05181 P05181 CYP2E1 PTHR24300:SF356 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 2E1 catalytic activity#GO:0003824;monooxygenase activity#GO:0004497;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;heme binding#GO:0020037;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen#GO:0016712;binding#GO:0005488;tetrapyrrole binding#GO:0046906 cellular response to stimulus#GO:0051716;arachidonate metabolic process#GO:0019369;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;xenobiotic metabolic process#GO:0006805;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;olefinic compound metabolic process#GO:0120254;oxoacid metabolic process#GO:0043436;response to xenobiotic stimulus#GO:0009410;cellular response to chemical stimulus#GO:0070887;cellular process#GO:0009987;long-chain fatty acid metabolic process#GO:0001676;cellular response to xenobiotic stimulus#GO:0071466;icosanoid metabolic process#GO:0006690;response to chemical#GO:0042221;lipid metabolic process#GO:0006629;unsaturated fatty acid metabolic process#GO:0033559;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229 oxidoreductase#PC00176;oxygenase#PC00177 HUMAN|HGNC=29560|UniProtKB=Q9P016 Q9P016 THYN1 PTHR14087:SF7 THYMOCYTE NUCLEAR PROTEIN 1 THYMOCYTE NUCLEAR PROTEIN 1 HUMAN|HGNC=9551|UniProtKB=P43686 P43686 PSMC4 PTHR23073:SF155 26S PROTEASOME REGULATORY SUBUNIT 26S PROTEASOME REGULATORY SUBUNIT 6B catalytic activity#GO:0003824;polypeptide conformation or assembly isomerase activity#GO:0120544;ATP-dependent activity#GO:0140657;macromolecular conformation isomerase activity#GO:0120543;isomerase activity#GO:0016853 metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498 peptidase complex#GO:1905368;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;proteasome complex#GO:0000502;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;catalytic complex#GO:1902494;endopeptidase complex#GO:1905369 protease#PC00190 Ubiquitin proteasome pathway#P00060>19S proteasome#P01494;Ubiquitin proteasome pathway#P00060>26S proteasome#P01489 HUMAN|HGNC=8051|UniProtKB=Q9NZJ9 Q9NZJ9 NUDT4 PTHR12629:SF6 DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE 2-RELATED hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817 organophosphate catabolic process#GO:0046434;nucleotide metabolic process#GO:0009117;small molecule catabolic process#GO:0044282;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;nucleoside phosphate catabolic process#GO:1901292;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;alcohol metabolic process#GO:0006066;nucleotide catabolic process#GO:0009166;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;nucleobase-containing compound catabolic process#GO:0034655 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 phosphatase#PC00181 HUMAN|HGNC=24022|UniProtKB=Q9BYD9 Q9BYD9 ACTRT3 PTHR11937:SF159 ACTIN ACTIN-RELATED PROTEIN T3 structural molecule activity#GO:0005198;structural constituent of cytoskeleton#GO:0005200 intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165;actin cytoskeleton#GO:0015629;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 actin and actin related protein#PC00039 Alzheimer disease-presenilin pathway#P00004>actin#P00114;Cytoskeletal regulation by Rho GTPase#P00016>Actin#P00512;Wnt signaling pathway#P00057>NFAT Target Genes#G01559;Cadherin signaling pathway#P00012>F-actin#P00470;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>F-actin#P00858;Nicotinic acetylcholine receptor signaling pathway#P00044>Actin#P01090;Huntington disease#P00029>Actin#P00807;Integrin signalling pathway#P00034>Actin#P00944 HUMAN|HGNC=6840|UniProtKB=Q02750 Q02750 MAP2K1 PTHR48013:SF5 DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 protein kinase activity#GO:0004672;catalytic activity, acting on a protein#GO:0140096;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740 neuron differentiation#GO:0030182;developmental process#GO:0032502;neurogenesis#GO:0022008;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;nervous system development#GO:0007399;intracellular signaling cassette#GO:0141124;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;MAPK cascade#GO:0000165;anatomical structure development#GO:0048856;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;signaling#GO:0023052;cell differentiation#GO:0030154;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 non-receptor serine/threonine protein kinase#PC00167 Gonadotropin-releasing hormone receptor pathway#P06664>MEK1/2#P06739;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>MEK#P00891;VEGF signaling pathway#P00056>MEK#P01402;FGF signaling pathway#P00021>MEK1-2#P00642;Integrin signalling pathway#P00034>ERK#P00907;Ras Pathway#P04393>MEK#P04557;Gonadotropin-releasing hormone receptor pathway#P06664>MAP2K1/2#P06794;Endothelin signaling pathway#P00019>MEK#P00572;Integrin signalling pathway#P00034>MEK#P00925;B cell activation#P00010>MEK#P00383;CCKR signaling map#P06959>MAP2K1#P07194;EGF receptor signaling pathway#P00018>MEK1-2#P00559;Toll receptor signaling pathway#P00054>MKK1#P01369;T cell activation#P00053>MEK#P01312;Angiotensin II-stimulated signaling through G proteins and beta-arrestin#P05911>MEK#P05926;Angiogenesis#P00005>MEK#P00225;PDGF signaling pathway#P00047>MEK#P01162 HUMAN|HGNC=18206|UniProtKB=Q9H336 Q9H336 CRISPLD1 PTHR10334:SF73 CYSTEINE-RICH SECRETORY PROTEIN-RELATED CYSTEINE-RICH SECRETORY PROTEIN LCCL DOMAIN-CONTAINING 1 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090 HUMAN|HGNC=29399|UniProtKB=Q96PX9 Q96PX9 PLEKHG4B PTHR45845:SF1 RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR-RELATED PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 4B guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=3951|UniProtKB=Q16595 Q16595 FXN PTHR16821:SF4 FRATAXIN FRATAXIN, MITOCHONDRIAL metal ion binding#GO:0046872;cation binding#GO:0043169;iron-sulfur cluster binding#GO:0051536;binding#GO:0005488;small molecule binding#GO:0036094;molecular carrier activity#GO:0140104;ion binding#GO:0043167;transition metal ion binding#GO:0046914;iron ion binding#GO:0005506;ferrous iron binding#GO:0008198 cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;iron-sulfur cluster assembly#GO:0016226;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;cellular process#GO:0009987 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 transfer/carrier protein#PC00219 HUMAN|HGNC=39433|UniProtKB=P0CW18 P0CW18 PRSS56 PTHR24278:SF32 COAGULATION FACTOR SERINE PROTEASE 56 serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;serine-type peptidase activity#GO:0008236;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;catalytic activity#GO:0003824 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 serine protease#PC00203 HUMAN|HGNC=20039|UniProtKB=P40123 P40123 CAP2 PTHR10652:SF2 ADENYLYL CYCLASE-ASSOCIATED PROTEIN ADENYLYL CYCLASE-ASSOCIATED PROTEIN 2 protein binding#GO:0005515;binding#GO:0005488;enzyme binding#GO:0019899;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092 cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;cell morphogenesis#GO:0000902;anatomical structure morphogenesis#GO:0009653;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cellular component organization or biogenesis#GO:0071840;anatomical structure development#GO:0048856;developmental process#GO:0032502;actin filament-based process#GO:0030029 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 actin or actin-binding cytoskeletal protein#PC00041;cytoskeletal protein#PC00085 HUMAN|HGNC=16173|UniProtKB=Q9P104 Q9P104 DOK5 PTHR21258:SF45 DOCKING PROTEIN RELATED DOCKING PROTEIN 5 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cell surface receptor signaling pathway#GO:0007166;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154 scaffold/adaptor protein#PC00226 HUMAN|HGNC=2212|UniProtKB=P12110 P12110 COL6A2 PTHR24020:SF29 COLLAGEN ALPHA COLLAGEN ALPHA-2(VI) CHAIN extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical structure#GO:0110165 extracellular matrix structural protein#PC00103 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>EMC#P00863;Integrin signalling pathway#P00034>Collagen#P00922 HUMAN|HGNC=28737|UniProtKB=Q8IXM2 Q8IXM2 BACC1 PTHR21397:SF2 CHROMATIN COMPLEXES SUBUNIT BAP18-RELATED BPTF-ASSOCIATED CHROMATIN COMPLEX COMPONENT 1 membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;histone methyltransferase complex#GO:0035097;transferase complex#GO:1990234;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;chromatin#GO:0000785;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ISWI-type complex#GO:0031010;ATPase complex#GO:1904949;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;methyltransferase complex#GO:0034708;organelle#GO:0043226;SWI/SNF superfamily-type complex#GO:0070603;chromosome#GO:0005694;organelle lumen#GO:0043233 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=49151|UniProtKB=Q9Y3D8 Q9Y3D8 AK6 PTHR12595:SF19 POS9-ACTIVATING FACTOR FAP7-RELATED ADENYLATE KINASE ISOENZYME 6 ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;nucleotide binding#GO:0000166;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, phosphate group as acceptor#GO:0016776;nucleoside phosphate binding#GO:1901265;nucleobase-containing compound kinase activity#GO:0019205;ATP binding#GO:0005524;binding#GO:0005488;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;carbohydrate derivative binding#GO:0097367;transferase activity#GO:0016740;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;kinase activity#GO:0016301;ribonucleotide binding#GO:0032553 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=673|UniProtKB=Q07960 Q07960 ARHGAP1 PTHR45808:SF6 RHO GTPASE-ACTIVATING PROTEIN 68F RHO GTPASE-ACTIVATING PROTEIN 1 enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772 regulation of cellular process#GO:0050794;negative regulation of transport#GO:0051051;response to stimulus#GO:0050896;signaling#GO:0023052;negative regulation of biological process#GO:0048519;cellular response to stimulus#GO:0051716;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;intracellular signaling cassette#GO:0141124;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of localization#GO:0032879;regulation of transport#GO:0051049;negative regulation of cellular process#GO:0048523 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 PDGF signaling pathway#P00047>Rho#P01174;VEGF signaling pathway#P00056>Rac#P01421;Angiogenesis#P00005>Rac#P00245;Cytoskeletal regulation by Rho GTPase#P00016>Rho GAPs#P00520 HUMAN|HGNC=15030|UniProtKB=Q8NGY3 Q8NGY3 OR6K3 PTHR26451:SF956 G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN OLFACTORY RECEPTOR 6K3 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;binding#GO:0005488;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 system process#GO:0003008;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;nervous system process#GO:0050877;sensory perception#GO:0007600;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;response to stimulus#GO:0050896;response to chemical#GO:0042221;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;detection of chemical stimulus#GO:0009593 membrane#GO:0016020;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021 HUMAN|HGNC=12607|UniProtKB=O94782 O94782 USP1 PTHR24006:SF905 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 1 deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787;cysteine-type peptidase activity#GO:0008234;cysteine-type deubiquitinase activity#GO:0004843;catalytic activity#GO:0003824;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096 regulation of protein stability#GO:0031647;regulation of biological quality#GO:0065008;biological regulation#GO:0065007 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 cysteine protease#PC00081;protease#PC00190 HUMAN|HGNC=10975|UniProtKB=O60721 O60721 SLC24A1 PTHR10846:SF36 SODIUM/POTASSIUM/CALCIUM EXCHANGER SODIUM_POTASSIUM_CALCIUM EXCHANGER 1 potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;monoatomic cation channel activity#GO:0005261;sodium ion transmembrane transporter activity#GO:0015081;active transmembrane transporter activity#GO:0022804;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;antiporter activity#GO:0015297;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291 regulation of signaling#GO:0023051;inorganic ion homeostasis#GO:0098771;positive regulation of synaptic transmission#GO:0050806;calcium ion homeostasis#GO:0055074;negative regulation of signaling#GO:0023057;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;negative regulation of cell communication#GO:0010648;transmembrane transport#GO:0055085;positive regulation of signaling#GO:0023056;regulation of biological process#GO:0050789;calcium ion transmembrane transport#GO:0070588;intracellular monoatomic ion homeostasis#GO:0006873;negative regulation of biological process#GO:0048519;chemical homeostasis#GO:0048878;calcium ion transport#GO:0006816;intracellular calcium ion homeostasis#GO:0006874;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;monoatomic ion homeostasis#GO:0050801;monoatomic cation transmembrane transport#GO:0098655;regulation of trans-synaptic signaling#GO:0099177;localization#GO:0051179;monoatomic cation transport#GO:0006812;regulation of cell communication#GO:0010646;homeostatic process#GO:0042592;modulation of chemical synaptic transmission#GO:0050804;metal ion transport#GO:0030001;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;negative regulation of cellular process#GO:0048523;regulation of synaptic plasticity#GO:0048167;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;establishment of localization#GO:0051234;positive regulation of cellular process#GO:0048522;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 secondary carrier transporter#PC00258 HUMAN|HGNC=20820|UniProtKB=Q8NHX9 Q8NHX9 TPCN2 PTHR46768:SF1 TWO PORE CALCIUM CHANNEL PROTEIN 2 TWO PORE CHANNEL PROTEIN 2 ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;sodium channel activity#GO:0005272;transporter activity#GO:0005215;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;monoatomic cation channel activity#GO:0005261;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;gated channel activity#GO:0022836;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;calcium-mediated signaling#GO:0019722;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;intracellular signaling cassette#GO:0141124;biological process involved in interaction with host#GO:0051701;biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052;biological regulation#GO:0065007;biological process involved in symbiotic interaction#GO:0044403;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;lytic vacuole membrane#GO:0098852;lysosome#GO:0005764;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;vacuole#GO:0005773;membrane#GO:0016020;lysosomal membrane#GO:0005765;vacuolar membrane#GO:0005774;lytic vacuole#GO:0000323;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090 ion channel#PC00133 CCKR signaling map#P06959>TPC1/2#P07209 HUMAN|HGNC=28909|UniProtKB=O60826 O60826 CCDC22 PTHR15668:SF5 JM1 PROTEIN COILED-COIL DOMAIN-CONTAINING PROTEIN 22 binding#GO:0005488;protein binding#GO:0005515 endosomal transport#GO:0016197;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;positive regulation of macromolecule metabolic process#GO:0010604;vesicle-mediated transport#GO:0016192;regulation of protein metabolic process#GO:0051246;establishment of localization in cell#GO:0051649;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of metabolic process#GO:0009893;cellular localization#GO:0051641;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;positive regulation of protein metabolic process#GO:0051247;endocytic recycling#GO:0032456;regulation of biological process#GO:0050789;establishment of localization#GO:0051234;positive regulation of catabolic process#GO:0009896;vesicle-mediated transport to the plasma membrane#GO:0098876;regulation of catabolic process#GO:0009894;intracellular transport#GO:0046907;transport#GO:0006810;regulation of response to stimulus#GO:0048583;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;regulation of canonical NF-kappaB signal transduction#GO:0043122;localization#GO:0051179;positive regulation of protein catabolic process#GO:0045732;regulation of protein catabolic process#GO:0042176;localization within membrane#GO:0051668;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;positive regulation of ubiquitin-dependent protein catabolic process#GO:2000060 HUMAN|HGNC=34000|UniProtKB=A6PVC2 A6PVC2 TTLL8 PTHR45870:SF3 TUBULIN MONOGLYCYLASE TTLL3 PROTEIN MONOGLYCYLASE TTLL8 catalytic activity, acting on a protein#GO:0140096;ligase activity, forming carbon-nitrogen bonds#GO:0016879;catalytic activity#GO:0003824;ligase activity#GO:0016874 male gamete generation#GO:0048232;plasma membrane bounded cell projection organization#GO:0120036;plasma membrane bounded cell projection assembly#GO:0120031;flagellated sperm motility#GO:0030317;developmental process#GO:0032502;spermatogenesis#GO:0007283;developmental process involved in reproduction#GO:0003006;microtubule-based movement#GO:0007018;cell motility#GO:0048870;reproductive process#GO:0022414;organelle assembly#GO:0070925;microtubule bundle formation#GO:0001578;sexual reproduction#GO:0019953;microtubule cytoskeleton organization#GO:0000226;multicellular organismal reproductive process#GO:0048609;axoneme assembly#GO:0035082;cilium movement involved in cell motility#GO:0060294;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;cilium assembly#GO:0060271;cellular component organization#GO:0016043;sperm motility#GO:0097722;gamete generation#GO:0007276;cell projection organization#GO:0030030;cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;cilium-dependent cell motility#GO:0060285;cilium organization#GO:0044782 cilium#GO:0005929;9+2 motile cilium#GO:0097729;intracellular organelle#GO:0043229;axoneme#GO:0005930;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;motile cilium#GO:0031514;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;sperm flagellum#GO:0036126;ciliary plasm#GO:0097014;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232 HUMAN|HGNC=26104|UniProtKB=Q9H7E9 Q9H7E9 C8orf33 PTHR13602:SF2 UPF0488 PROTEIN C8ORF33 UPF0488 PROTEIN C8ORF33 HUMAN|HGNC=25872|UniProtKB=Q9H7X3 Q9H7X3 ZNF696 PTHR24379:SF77 KRAB AND ZINC FINGER DOMAIN-CONTAINING ZINC FINGER PROTEIN 696 double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218;C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HUMAN|HGNC=34298|UniProtKB=A6NIV6 A6NIV6 LRRIQ4 PTHR48051:SF28 FAMILY NOT NAMED LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 4 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=19002|UniProtKB=Q8N568 Q8N568 DCLK2 PTHR24347:SF376 SERINE/THREONINE-PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE DCLK2 protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824 microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=9243|UniProtKB=O14829 O14829 PPEF1 PTHR45668:SF1 SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED SERINE_THREONINE-PROTEIN PHOSPHATASE WITH EF-HANDS 1 protein phosphatase#PC00195 HUMAN|HGNC=9826|UniProtKB=Q92698 Q92698 RAD54L PTHR45629:SF17 SNF2/RAD54 FAMILY MEMBER DNA REPAIR AND RECOMBINATION PROTEIN RAD54-LIKE ATP-dependent activity, acting on DNA#GO:0008094;catalytic activity, acting on DNA#GO:0140097;DNA translocase activity#GO:0015616;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640 reciprocal meiotic recombination#GO:0007131;cellular response to stress#GO:0033554;nuclear division#GO:0000280;double-strand break repair via homologous recombination#GO:0000724;cell cycle process#GO:0022402;meiotic cell cycle process#GO:1903046;meiosis I#GO:0007127;cellular component organization#GO:0016043;response to stimulus#GO:0050896;DNA recombination#GO:0006310;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;meiotic cell cycle#GO:0051321;double-strand break repair#GO:0006302;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;response to stress#GO:0006950;organelle organization#GO:0006996;sexual reproduction#GO:0019953;recombinational repair#GO:0000725;meiosis I cell cycle process#GO:0061982;organelle fission#GO:0048285;cellular response to stimulus#GO:0051716;reciprocal homologous recombination#GO:0140527;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cell cycle#GO:0007049;reproductive process#GO:0022414;homologous recombination#GO:0035825;DNA damage response#GO:0006974;DNA repair#GO:0006281;meiotic nuclear division#GO:0140013;macromolecule metabolic process#GO:0043170;nucleobase-containing compound metabolic process#GO:0006139 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 damaged DNA-binding protein#PC00086 HUMAN|HGNC=28758|UniProtKB=Q14CZ7 Q14CZ7 FASTKD3 PTHR21228:SF9 FAST LEU-RICH DOMAIN-CONTAINING FAST KINASE DOMAIN-CONTAINING PROTEIN 3, MITOCHONDRIAL RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of mRNA stability#GO:0043488;regulation of mRNA catabolic process#GO:0061013;regulation of biological process#GO:0050789;RNA metabolic process#GO:0016070;regulation of biological quality#GO:0065008;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;RNA processing#GO:0006396;cellular process#GO:0009987;regulation of mRNA metabolic process#GO:1903311;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mitochondrial RNA metabolic process#GO:0000959;regulation of RNA metabolic process#GO:0051252;mitochondrial gene expression#GO:0140053;regulation of RNA stability#GO:0043487;regulation of nucleobase-containing compound metabolic process#GO:0019219;biosynthetic process#GO:0009058;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;mitochondrial RNA processing#GO:0000963;macromolecule biosynthetic process#GO:0009059;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;post-transcriptional regulation of gene expression#GO:0010608 membrane-enclosed lumen#GO:0031974;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228;organelle lumen#GO:0043233;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 RNA processing factor#PC00147 HUMAN|HGNC=143|UniProtKB=P68032 P68032 ACTC1 PTHR11937:SF176 ACTIN ACTIN, ALPHA CARDIAC MUSCLE 1 cytoskeletal protein binding#GO:0008092;structural constituent of cytoskeleton#GO:0005200;myosin binding#GO:0017022;binding#GO:0005488;structural molecule activity#GO:0005198;protein binding#GO:0005515 organelle organization#GO:0006996;actin filament-based movement#GO:0030048;cellular process#GO:0009987;multicellular organismal process#GO:0032501;blood circulation#GO:0008015;cytoskeleton organization#GO:0007010;cellular component organization or biogenesis#GO:0071840;heart contraction#GO:0060047;actin filament organization#GO:0007015;system process#GO:0003008;cellular component organization#GO:0016043;heart process#GO:0003015;actin cytoskeleton organization#GO:0030036;actin-mediated cell contraction#GO:0070252;circulatory system process#GO:0003013;actin filament-based process#GO:0030029;supramolecular fiber organization#GO:0097435 actin cytoskeleton#GO:0015629;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;myofibril#GO:0030016;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;contractile muscle fiber#GO:0043292;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;cytoskeleton#GO:0005856;actin filament#GO:0005884;sarcomere#GO:0030017;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228 actin and actin related protein#PC00039 Nicotinic acetylcholine receptor signaling pathway#P00044>Actin#P01090;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>F-actin#P00858;Integrin signalling pathway#P00034>Actin#P00944;Huntington disease#P00029>Actin#P00807;Cytoskeletal regulation by Rho GTPase#P00016>Actin#P00512;Alzheimer disease-presenilin pathway#P00004>actin#P00114;Wnt signaling pathway#P00057>NFAT Target Genes#G01559;Cadherin signaling pathway#P00012>F-actin#P00470 HUMAN|HGNC=33205|UniProtKB=Q1AE95 Q1AE95 TMEM183BP PTHR20988:SF2 TRANSMEMBRANE PROTEIN 183A-RELATED TRANSMEMBRANE PROTEIN 183A-RELATED ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;SCF ubiquitin ligase complex#GO:0019005;intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461;catalytic complex#GO:1902494;transferase complex#GO:1990234 HUMAN|HGNC=20454|UniProtKB=Q9H9Y6 Q9H9Y6 POLR1B PTHR20856:SF5 DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2 DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA2 transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on RNA#GO:0140098 nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;DNA-templated transcription elongation#GO:0006354;transcription by RNA polymerase I#GO:0006360;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058 catalytic complex#GO:1902494;RNA polymerase I complex#GO:0005736;intracellular organelle#GO:0043229;nucleolus#GO:0005730;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991 DNA-directed RNA polymerase#PC00019;RNA metabolism protein#PC00031 General transcription by RNA polymerase I#P00022>RNA Polymerase I Complex#P00652 HUMAN|HGNC=6272|UniProtKB=O00180 O00180 KCNK1 PTHR11003:SF353 POTASSIUM CHANNEL, SUBFAMILY K POTASSIUM CHANNEL SUBFAMILY K MEMBER 1 voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated monoatomic ion channel activity#GO:0005244;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;transporter activity#GO:0005215;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;outward rectifier potassium channel activity#GO:0015271;potassium channel activity#GO:0005267;monoatomic cation channel activity#GO:0005261;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857 cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;metal ion transport#GO:0030001;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813;transport#GO:0006810;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;establishment of localization#GO:0051234 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=12922|UniProtKB=P52744 P52744 ZNF138 PTHR24384:SF211 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED ZINC FINGER PROTEIN 138-RELATED cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218 HUMAN|HGNC=5002|UniProtKB=Q9P0W2 Q9P0W2 HMG20B PTHR46040:SF2 HIGH MOBILITY GROUP PROTEIN 2 SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY E MEMBER 1-RELATED biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=24923|UniProtKB=Q9Y5R4 Q9Y5R4 HEMK1 PTHR18895:SF74 HEMK METHYLTRANSFERASE MTRF1L RELEASE FACTOR GLUTAMINE METHYLTRANSFERASE N-methyltransferase activity#GO:0008170;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;catalytic activity, acting on a protein#GO:0140096;protein methyltransferase activity#GO:0008276;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity#GO:0003824;transferase activity#GO:0016740 translational termination#GO:0006415;translation#GO:0006412;cellular component disassembly#GO:0022411;protein metabolic process#GO:0019538;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;protein biosynthetic process#GO:0160307;protein-containing complex disassembly#GO:0032984;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;biosynthetic process#GO:0009058 mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 protein modifying enzyme#PC00260 HUMAN|HGNC=6158|UniProtKB=P16144 P16144 ITGB4 PTHR10082:SF42 INTEGRIN BETA SUBUNIT INTEGRIN BETA-4 cell adhesion molecule binding#GO:0050839;signaling receptor binding#GO:0005102;binding#GO:0005488;integrin binding#GO:0005178;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 signaling#GO:0023052;regulation of cellular process#GO:0050794;cell motility#GO:0048870;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;integrin-mediated signaling pathway#GO:0007229;cell-substrate adhesion#GO:0031589;cell communication#GO:0007154;cell adhesion#GO:0007155;cell-matrix adhesion#GO:0007160;biological regulation#GO:0065007;cell migration#GO:0016477;cellular process#GO:0009987;signal transduction#GO:0007165;cell-cell adhesion#GO:0098609;cell surface receptor signaling pathway#GO:0007166;cell adhesion mediated by integrin#GO:0033627 plasma membrane#GO:0005886;cell-substrate junction#GO:0030055;focal adhesion#GO:0005925;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;protein complex involved in cell adhesion#GO:0098636;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane protein complex#GO:0098796;membrane#GO:0016020;anchoring junction#GO:0070161;cell junction#GO:0030054;integrin complex#GO:0008305;signaling receptor complex#GO:0043235 integrin#PC00126 Integrin signalling pathway#P00034>Integrin beta#P00931 HUMAN|HGNC=12963|UniProtKB=Q15697 Q15697 ZNF174 PTHR23226:SF175 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER PROTEIN 174 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=6529|UniProtKB=Q13094 Q13094 LCP2 PTHR14098:SF1 SH2 DOMAIN CONTAINING PROTEIN LYMPHOCYTE CYTOSOLIC PROTEIN 2 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 multicellular organismal process#GO:0032501;myeloid leukocyte activation#GO:0002274;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;cell surface receptor signaling pathway#GO:0007166;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;leukocyte activation#GO:0045321;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;immune system process#GO:0002376;cell activation#GO:0001775;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 scaffold/adaptor protein#PC00226 T cell activation#P00053>SLP-76#P01321 HUMAN|HGNC=15215|UniProtKB=Q96RD3 Q96RD3 OR52E6 PTHR26450:SF175 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 52E6 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=22644|UniProtKB=Q8NHW6 Q8NHW6 OTOS PTHR35073:SF1 OTOSPIRALIN OTOSPIRALIN system process#GO:0003008;sensory perception of sound#GO:0007605;multicellular organismal process#GO:0032501;sensory perception#GO:0007600;sensory perception of mechanical stimulus#GO:0050954;nervous system process#GO:0050877 HUMAN|HGNC=10291|UniProtKB=P35244 P35244 RPA3 PTHR15114:SF1 REPLICATION PROTEIN A3 REPLICATION PROTEIN A 14 KDA SUBUNIT binding#GO:0005488;nucleic acid binding#GO:0003676;single-stranded DNA binding#GO:0003697;damaged DNA binding#GO:0003684;DNA binding#GO:0003677 nucleotide-excision repair#GO:0006289;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;response to stress#GO:0006950;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;DNA recombination#GO:0006310;DNA damage response#GO:0006974;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;response to stimulus#GO:0050896;DNA replication#GO:0006260;cellular response to stimulus#GO:0051716;mismatch repair#GO:0006298;double-strand break repair via homologous recombination#GO:0000724;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;base-excision repair#GO:0006284;cellular response to stress#GO:0033554;recombinational repair#GO:0000725 organelle lumen#GO:0043233;chromosome#GO:0005694;replisome#GO:0030894;replication fork#GO:0005657;protein-DNA complex#GO:0032993;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nuclear replication fork#GO:0043596;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;site of DNA damage#GO:0090734;intracellular anatomical structure#GO:0005622;membrane-enclosed lumen#GO:0031974;site of double-strand break#GO:0035861;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228 Cell cycle#P00013>Pre-replication Complex#P00478 HUMAN|HGNC=6491|UniProtKB=A4D0S4 A4D0S4 LAMB4 PTHR10574:SF279 NETRIN/LAMININ-RELATED LAMININ SUBUNIT BETA-4 multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cell projection morphogenesis#GO:0048858;neuron differentiation#GO:0030182;substrate adhesion-dependent cell spreading#GO:0034446;plasma membrane bounded cell projection morphogenesis#GO:0120039;cellular component assembly#GO:0022607;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;neuron projection development#GO:0031175;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;neuron development#GO:0048666;axonogenesis#GO:0007409;extracellular structure organization#GO:0043062;animal gross anatomical part developmental process#GO:0160108;cell adhesion#GO:0007155;generation of neurons#GO:0048699;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell morphogenesis#GO:0000902;cell development#GO:0048468;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cellular developmental process#GO:0048869;neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;tissue development#GO:0009888;multicellular organismal process#GO:0032501;extracellular matrix assembly#GO:0085029;cell migration#GO:0016477;plasma membrane bounded cell projection organization#GO:0120036;axon guidance#GO:0007411;axon development#GO:0061564;cell-substrate adhesion#GO:0031589;anatomical structure development#GO:0048856;extracellular matrix organization#GO:0030198;external encapsulating structure organization#GO:0045229;system development#GO:0048731;cell motility#GO:0048870 supramolecular complex#GO:0099080;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;basement membrane#GO:0005604;extracellular protein-containing complex#GO:0140392;extracellular region#GO:0005576 extracellular matrix protein#PC00102 Integrin signalling pathway#P00034>Laminin#P00947 HUMAN|HGNC=12839|UniProtKB=O75191 O75191 XYLB PTHR10196:SF57 SUGAR KINASE XYLULOSE KINASE kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;carbohydrate kinase activity#GO:0019200;phosphotransferase activity, alcohol group as acceptor#GO:0016773 carbohydrate metabolic process#GO:0005975;small molecule metabolic process#GO:0044281;cellular process#GO:0009987;monosaccharide metabolic process#GO:0005996;primary metabolic process#GO:0044238;metabolic process#GO:0008152 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 carbohydrate kinase#PC00065;kinase#PC00137 Ascorbate degradation#P02729>L-xylulose kinase#P02849 HUMAN|HGNC=1928|UniProtKB=O00409 O00409 FOXN3 PTHR13962:SF20 FORKHEAD BOX PROTEIN N3-LIKE PROTEIN-RELATED FORKHEAD BOX PROTEIN N3 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 winged helix/forkhead transcription factor#PC00246 HUMAN|HGNC=28966|UniProtKB=Q14135 Q14135 VGLL4 PTHR17604:SF1 TRANSCRIPTION COFACTOR VESTIGIAL-LIKE PROTEIN 4 TRANSCRIPTION COFACTOR VESTIGIAL-LIKE PROTEIN 4 binding#GO:0005488;transcription factor binding#GO:0008134;protein binding#GO:0005515 regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605 transcription cofactor#PC00217 HUMAN|HGNC=5122|UniProtKB=Q9NYD6 Q9NYD6 HOXC10 PTHR45874:SF2 HOMEOBOX PROTEIN ABDOMINAL-B HOMEOBOX PROTEIN HOX-C10 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 homeodomain transcription factor#PC00119 HUMAN|HGNC=15743|UniProtKB=Q96PL5 Q96PL5 ERMAP PTHR24100:SF46 BUTYROPHILIN ERYTHROID MEMBRANE-ASSOCIATED PROTEIN binding#GO:0005488;signaling receptor binding#GO:0005102;protein binding#GO:0005515 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cytokine production#GO:0001817;positive regulation of response to stimulus#GO:0048584;immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007;T cell receptor signaling pathway#GO:0050852;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of macromolecule metabolic process#GO:0060255;immune response-activating cell surface receptor signaling pathway#GO:0002429;regulation of immune response#GO:0050776;cell communication#GO:0007154;positive regulation of immune system process#GO:0002684;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;signal transduction#GO:0007165;antigen receptor-mediated signaling pathway#GO:0050851;regulation of multicellular organismal process#GO:0051239;cell surface receptor signaling pathway#GO:0007166;immune response-activating signaling pathway#GO:0002757;immune response-regulating signaling pathway#GO:0002764;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signaling#GO:0023052;immune system process#GO:0002376 side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=16933|UniProtKB=Q96JP0 Q96JP0 FEM1C PTHR24173:SF14 ANKYRIN REPEAT CONTAINING PROTEIN FEM-1 HOMOLOG C enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 intracellular protein-containing complex#GO:0140535;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;transferase complex#GO:1990234;catalytic complex#GO:1902494 scaffold/adaptor protein#PC00226 HUMAN|HGNC=1693|UniProtKB=P34810 P34810 CD68 PTHR11506:SF2 LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN MACROSIALIN establishment of protein localization#GO:0045184;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;localization#GO:0051179 vesicle#GO:0031982;lysosome#GO:0005764;lytic vacuole membrane#GO:0098852;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endosome#GO:0005768;endosome membrane#GO:0010008;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;cell periphery#GO:0071944;lysosomal membrane#GO:0005765;vesicle membrane#GO:0012506;membrane#GO:0016020;vacuole#GO:0005773;plasma membrane#GO:0005886;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;late endosome#GO:0005770;late endosome membrane#GO:0031902;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;lytic vacuole#GO:0000323;vacuolar membrane#GO:0005774 membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=25823|UniProtKB=Q6N063 Q6N063 OGFOD2 PTHR24014:SF4 2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE DOMAIN-CONTAINING PROTEIN 2 2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE DOMAIN-CONTAINING PROTEIN 2 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 RNA metabolism protein#PC00031 HUMAN|HGNC=18799|UniProtKB=Q99766 Q99766 DMAC2L PTHR13382:SF10 MITOCHONDRIAL ATP SYNTHASE COUPLING FACTOR B ATP SYNTHASE SUBUNIT S, MITOCHONDRIAL cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 ATP synthase#PC00002 HUMAN|HGNC=30004|UniProtKB=P0DMN0 P0DMN0 SULT1A4 PTHR11783:SF308 SULFOTRANSFERASE SULT SULFOTRANSFERASE 1A3-RELATED transferase activity, transferring sulphur-containing groups#GO:0016782;sulfotransferase activity#GO:0008146;catalytic activity#GO:0003824;transferase activity#GO:0016740 cellular process#GO:0009987;metabolic process#GO:0008152;sulfur compound metabolic process#GO:0006790 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 transferase#PC00220;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=8149|UniProtKB=O14841 O14841 OPLAH PTHR11365:SF2 5-OXOPROLINASE RELATED 5-OXOPROLINASE hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides#GO:0016812 cellular process#GO:0009987;glutathione metabolic process#GO:0006749;modified amino acid metabolic process#GO:0006575;sulfur compound metabolic process#GO:0006790;metabolic process#GO:0008152;sulfur compound catabolic process#GO:0044273;catabolic process#GO:0009056 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 hydrolase#PC00121;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=20742|UniProtKB=Q5TGI0 Q5TGI0 FAXC PTHR12289:SF76 METAXIN RELATED FAILED AXON CONNECTIONS HOMOLOG transporter#PC00227 HUMAN|HGNC=34455|UniProtKB=A8MZG2 A8MZG2 C16orf90 PTHR37334:SF1 RGD1561796 SIMILAR TO HUMAN CHROMOSOME 16 OPEN READING FRAME 90 HUMAN|HGNC=6962|UniProtKB=P49901 P49901 SMCP PTHR35820:SF1 SPERM MITOCHONDRIAL-ASSOCIATED CYSTEINE-RICH PROTEIN SPERM MITOCHONDRIAL-ASSOCIATED CYSTEINE-RICH PROTEIN HUMAN|HGNC=37163|UniProtKB=P0CJ73 P0CJ73 MTRNR2L6 PTHR33895:SF18 HUMANIN-LIKE 4 HUMANIN-LIKE 1-RELATED molecular function inhibitor activity#GO:0140678;molecular function regulator activity#GO:0098772;signaling receptor inhibitor activity#GO:0030547;signaling receptor regulator activity#GO:0030545 regulation of apoptotic process#GO:0042981;negative regulation of cellular process#GO:0048523;negative regulation of programmed cell death#GO:0043069;regulation of biological process#GO:0050789;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;biological regulation#GO:0065007;negative regulation of apoptotic process#GO:0043066;regulation of cellular process#GO:0050794 HUMAN|HGNC=8156|UniProtKB=P35372 P35372 OPRM1 PTHR24229:SF7 NEUROPEPTIDES RECEPTOR MU-TYPE OPIOID RECEPTOR signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;protein binding#GO:0005515;molecular transducer activity#GO:0060089;neuropeptide binding#GO:0042923;peptide binding#GO:0042277;transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;neuropeptide receptor activity#GO:0008188;binding#GO:0005488 system process#GO:0003008;signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;sensory perception#GO:0007600;nervous system process#GO:0050877;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;sensory perception of pain#GO:0019233;neuropeptide signaling pathway#GO:0007218;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;neuron projection#GO:0043005;membrane#GO:0016020 G-protein coupled receptor#PC00021 Opioid proopiomelanocortin pathway#P05917>Mu or Delta receptor#P06004;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;Enkephalin release#P05913>GPCR (s)#P05975;Opioid proenkephalin pathway#P05915>Mu or Delta receptor#P05985;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GoPCR#P00725 HUMAN|HGNC=15876|UniProtKB=Q96A57 Q96A57 TMEM230 PTHR15664:SF27 C20ORF30 PROTEIN TRANSMEMBRANE PROTEIN 230 localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;organelle localization#GO:0051640;transport#GO:0006810;synaptic vesicle localization#GO:0097479;establishment of organelle localization#GO:0051656;establishment of vesicle localization#GO:0051650;synaptic vesicle transport#GO:0048489;establishment of localization in cell#GO:0051649;vesicle localization#GO:0051648;cellular process#GO:0009987 cell junction#GO:0030054;transport vesicle#GO:0030133;endomembrane system#GO:0012505;cytoplasm#GO:0005737;secretory vesicle#GO:0099503;presynapse#GO:0098793;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;organelle#GO:0043226;cellular anatomical structure#GO:0110165;synapse#GO:0045202;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;synaptic vesicle#GO:0008021 HUMAN|HGNC=28675|UniProtKB=Q86XK7 Q86XK7 VSIG1 PTHR44974:SF1 V-SET AND IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN 1 V-SET AND IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN 1 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=19137|UniProtKB=Q5ZPR3 Q5ZPR3 CD276 PTHR24100:SF155 BUTYROPHILIN CD276 ANTIGEN binding#GO:0005488;signaling receptor binding#GO:0005102;protein binding#GO:0005515 immune system process#GO:0002376;regulation of biological process#GO:0050789;immune response-regulating signaling pathway#GO:0002764;signaling#GO:0023052;response to stimulus#GO:0050896;cell surface receptor signaling pathway#GO:0007166;immune response-activating signaling pathway#GO:0002757;activation of immune response#GO:0002253;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of immune system process#GO:0002684;regulation of multicellular organismal process#GO:0051239;antigen receptor-mediated signaling pathway#GO:0050851;regulation of immune response#GO:0050776;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;immune response-activating cell surface receptor signaling pathway#GO:0002429;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;T cell receptor signaling pathway#GO:0050852;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of cytokine production#GO:0001817;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;positive regulation of response to stimulus#GO:0048584 plasma membrane#GO:0005886;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;membrane#GO:0016020 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=24758|UniProtKB=Q5BKX5 Q5BKX5 ACTMAP PTHR28631:SF1 UPF0692 PROTEIN C19ORF54 ACTIN MATURATION PROTEASE aminopeptidase activity#GO:0004177;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;exopeptidase activity#GO:0008238 cellular process#GO:0009987;protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604;metabolic process#GO:0008152;proteolysis#GO:0006508;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 HUMAN|HGNC=14722|UniProtKB=Q8NGS5 Q8NGS5 OR13C4 PTHR26453:SF14 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 13C4 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;nervous system process#GO:0050877;sensory perception#GO:0007600;system process#GO:0003008;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;detection of chemical stimulus#GO:0009593;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;response to chemical#GO:0042221;response to stimulus#GO:0050896 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=15255|UniProtKB=Q8NGI8 Q8NGI8 OR5AN1 PTHR26452:SF262 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5AN1 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606;nervous system process#GO:0050877;sensory perception#GO:0007600 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=9980|UniProtKB=O75679 O75679 RFPL3 PTHR24103:SF702 E3 UBIQUITIN-PROTEIN LIGASE TRIM RET FINGER PROTEIN-LIKE 3 ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 immune system process#GO:0002376;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;defense response#GO:0006952;regulation of gene expression#GO:0010468;response to external stimulus#GO:0009605;innate immune response#GO:0045087;regulation of biosynthetic process#GO:0009889;response to other organism#GO:0051707;biological regulation#GO:0065007;defense response to other organism#GO:0098542;defense response to symbiont#GO:0140546;immune response#GO:0006955;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;response to stress#GO:0006950;response to biotic stimulus#GO:0009607 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=26882|UniProtKB=Q8N7M0 Q8N7M0 DYNLT5 PTHR21255:SF64 T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN DYNEIN LIGHT CHAIN TCTEX-TYPE 5 binding#GO:0005488;protein binding#GO:0005515 microtubule-based process#GO:0007017;microtubule-based movement#GO:0007018;cellular process#GO:0009987 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoplasmic dynein complex#GO:0005868;microtubule cytoskeleton#GO:0015630;dynein complex#GO:0030286;microtubule associated complex#GO:0005875;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232 microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=51793|UniProtKB=A0A0U1RQI7 A0A0U1RQI7 KLF18 PTHR23235:SF156 KRUEPPEL-LIKE TRANSCRIPTION FACTOR KRUPPEL-LIKE FACTOR 18 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=19295|UniProtKB=Q96Q04 Q96Q04 LMTK3 PTHR24417:SF2 SERINE/THREONINE-PROTEIN KINASE LMTK1 SERINE_THREONINE-PROTEIN KINASE LMTK3 protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=35465|UniProtKB=P0CI01 P0CI01 SPDYE6 PTHR31156:SF15 WBSCR19-LIKE PROTEIN SPEEDY PROTEIN E10-RELATED HUMAN|HGNC=12796|UniProtKB=P19544 P19544 WT1 PTHR23235:SF49 KRUEPPEL-LIKE TRANSCRIPTION FACTOR WILMS TUMOR PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=56304|UniProtKB=P0DQW0 P0DQW0 ZC3H11C PTHR15725:SF13 ZN-FINGER, C-X8-C-X5-C-X3-H TYPE-CONTAINING ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 11B-RELATED RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;nitrogen compound transport#GO:0071705;macromolecule localization#GO:0033036;biosynthetic process#GO:0009058;gene expression#GO:0010467;transport#GO:0006810;RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907;metabolic process#GO:0008152;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;poly(A)+ mRNA export from nucleus#GO:0016973;establishment of RNA localization#GO:0051236;mRNA transport#GO:0051028;RNA localization#GO:0006403;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;nucleocytoplasmic transport#GO:0006913;nuclear export#GO:0051168;nuclear transport#GO:0051169;cellular localization#GO:0051641;mRNA export from nucleus#GO:0006406;nucleic acid transport#GO:0050657;localization#GO:0051179 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 RNA processing factor#PC00147 HUMAN|HGNC=3395|UniProtKB=P54760 P54760 EPHB4 PTHR24416:SF296 TYROSINE-PROTEIN KINASE RECEPTOR EPHRIN TYPE-B RECEPTOR 4 phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein tyrosine kinase activity#GO:0004714;molecular transducer activity#GO:0060089;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888;catalytic activity, acting on a protein#GO:0140096;signaling receptor activity#GO:0038023;transmembrane receptor protein kinase activity#GO:0019199;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 multicellular organismal process#GO:0032501;biological regulation#GO:0065007;tube development#GO:0035295;signal transduction#GO:0007165;cellular process#GO:0009987;multicellular organism development#GO:0007275;anatomical structure formation involved in morphogenesis#GO:0048646;vasculature development#GO:0001944;developmental process#GO:0032502;cell surface receptor signaling pathway#GO:0007166;response to stimulus#GO:0050896;circulatory system development#GO:0072359;regulation of cellular process#GO:0050794;signaling#GO:0023052;blood vessel morphogenesis#GO:0048514;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;ephrin receptor signaling pathway#GO:0048013;tube morphogenesis#GO:0035239;cellular response to stimulus#GO:0051716;blood vessel development#GO:0001568;cell communication#GO:0007154;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;angiogenesis#GO:0001525;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;signaling receptor complex#GO:0043235 transmembrane signal receptor#PC00197 HUMAN|HGNC=1325|UniProtKB=P04003 P04003 C4BPA PTHR19325:SF551 COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING C4B-BINDING PROTEIN ALPHA CHAIN leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immune system process#GO:0002376;immune effector process#GO:0002252;T cell mediated immunity#GO:0002456;response to stimulus#GO:0050896;adaptive immune response#GO:0002250;immune response#GO:0006955 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 defense/immunity protein#PC00090;complement component#PC00078 HUMAN|HGNC=8701|UniProtKB=Q9Y5H0 Q9Y5H0 PCDHGA3 PTHR24028:SF358 CADHERIN-87A PROTOCADHERIN GAMMA-A3 cellular process#GO:0009987;cell adhesion#GO:0007155 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 cadherin#PC00057;cell adhesion molecule#PC00069 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HUMAN|HGNC=10658|UniProtKB=P18827 P18827 SDC1 PTHR10915:SF5 SYNDECAN SYNDECAN-1 positive regulation of cellular component organization#GO:0051130;positive regulation of organelle organization#GO:0010638;regulation of organelle organization#GO:0033043;regulation of organelle assembly#GO:1902115;regulation of biological process#GO:0050789;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of cellular component biogenesis#GO:0044089;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of cellular component biogenesis#GO:0044087;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;cell surface#GO:0009986 transmembrane signal receptor#PC00197 HUMAN|HGNC=23206|UniProtKB=Q86TE4 Q86TE4 LUZP2 PTHR22414:SF0 LEUCINE ZIPPER PROTEIN 2 LEUCINE ZIPPER PROTEIN 2 HUMAN|HGNC=6483|UniProtKB=Q16787 Q16787 LAMA3 PTHR10574:SF285 NETRIN/LAMININ-RELATED LAMININ SUBUNIT ALPHA-3 structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;axonogenesis#GO:0007409;neuron development#GO:0048666;anatomical structure development#GO:0048856;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;cell development#GO:0048468;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell morphogenesis#GO:0000902;neuron differentiation#GO:0030182;developmental process#GO:0032502;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron projection morphogenesis#GO:0048812;cell projection morphogenesis#GO:0048858;neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;cellular process#GO:0009987;neuron projection development#GO:0031175;axon guidance#GO:0007411;axon development#GO:0061564;plasma membrane bounded cell projection organization#GO:0120036;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;tissue development#GO:0009888;multicellular organismal process#GO:0032501 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;basement membrane#GO:0005604;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 extracellular matrix protein#PC00102 Integrin signalling pathway#P00034>Laminin#P00947 HUMAN|HGNC=37093|UniProtKB=P0CG38 P0CG38 POTEI PTHR11937:SF547 ACTIN POTE ANKYRIN DOMAIN FAMILY MEMBER E-RELATED structural molecule activity#GO:0005198;structural constituent of synapse#GO:0098918;protein binding#GO:0005515;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;binding#GO:0005488;kinase binding#GO:0019900;structural constituent of cytoskeleton#GO:0005200 plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;neuron differentiation#GO:0030182;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;neurogenesis#GO:0022008;cell projection morphogenesis#GO:0048858;axon development#GO:0061564;neuron projection development#GO:0031175;cellular process#GO:0009987;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;plasma membrane bounded cell projection organization#GO:0120036;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;anatomical structure development#GO:0048856;neuron development#GO:0048666;axonogenesis#GO:0007409;system development#GO:0048731;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cell motility#GO:0048870;cell morphogenesis#GO:0000902;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell development#GO:0048468 protein acetyltransferase complex#GO:0031248;intracellular organelle#GO:0043229;acetyltransferase complex#GO:1902493;supramolecular fiber#GO:0099512;actin cytoskeleton#GO:0015629;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;cell projection#GO:0042995;actin filament#GO:0005884;cell junction#GO:0030054;histone acetyltransferase complex#GO:0000123;chromatin#GO:0000785;neuron projection#GO:0043005;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;supramolecular complex#GO:0099080;NuA4 histone acetyltransferase complex#GO:0035267;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;catalytic complex#GO:1902494;axon#GO:0030424;intracellular anatomical structure#GO:0005622;chromosome#GO:0005694;plasma membrane bounded cell projection#GO:0120025;cytoskeleton#GO:0005856;transferase complex#GO:1990234;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;intracellular protein-containing complex#GO:0140535;membrane#GO:0016020;H4 histone acetyltransferase complex#GO:1902562 actin and actin related protein#PC00039 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>F-actin#P00858;Alzheimer disease-presenilin pathway#P00004>actin#P00114;Nicotinic acetylcholine receptor signaling pathway#P00044>Actin#P01090;Cytoskeletal regulation by Rho GTPase#P00016>Actin#P00512;Cadherin signaling pathway#P00012>F-actin#P00470;Huntington disease#P00029>Actin#P00807;Integrin signalling pathway#P00034>Actin#P00944 HUMAN|HGNC=9957|UniProtKB=P78509 P78509 RELN PTHR11841:SF1 REELIN REELIN lipoprotein particle receptor binding#GO:0070325;protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488 cell motility#GO:0048870;cell differentiation#GO:0030154;central nervous system development#GO:0007417;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;anatomical structure development#GO:0048856;system development#GO:0048731;cellular process#GO:0009987;cell migration#GO:0016477;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;developmental process#GO:0032502;cellular developmental process#GO:0048869;neuron migration#GO:0001764;multicellular organism development#GO:0007275;neurogenesis#GO:0022008 extracellular region#GO:0005576;neuron projection#GO:0043005;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165 extracellular matrix protein#PC00102;extracellular matrix glycoprotein#PC00100 HUMAN|HGNC=8216|UniProtKB=Q8NGR5 Q8NGR5 OR1L4 PTHR48001:SF84 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 1L4 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cell communication#GO:0007154 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=26611|UniProtKB=Q9Y4D8 Q9Y4D8 HECTD4 PTHR46435:SF1 E3 UBIQUITIN-PROTEIN LIGASE HECTD4-RELATED E3 UBIQUITIN-PROTEIN LIGASE HECTD4-RELATED carbohydrate homeostasis#GO:0033500;chemical homeostasis#GO:0048878;glucose homeostasis#GO:0042593;homeostatic process#GO:0042592 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=6586|UniProtKB=Q9Y693 Q9Y693 LHFPL6 PTHR12489:SF12 LIPOMA HMGIC FUSION PARTNER-LIKE PROTEIN LHFPL TETRASPAN SUBFAMILY MEMBER 6 PROTEIN cellular anatomical structure#GO:0110165;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HUMAN|HGNC=3031|UniProtKB=Q99856 Q99856 ARID3A PTHR15348:SF1 AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN ARID DOMAIN- CONTAINING PROTEIN DEAD RINGER PROTEIN B-CELL REGULATOR OF IGH TRANSCRIPTION BRIGHT AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 3A DNA binding#GO:0003677;binding#GO:0005488;nucleic acid binding#GO:0003676 regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=13308|UniProtKB=Q9NZH0 Q9NZH0 GPRC5B PTHR14511:SF9 G PROTEIN COUPLED RECEPTOR, CLASS C, GROUP 5 G PROTEIN-COUPLED RECEPTOR FAMILY C GROUP 5 MEMBER B binding#GO:0005488;kinase binding#GO:0019900;kinase activator activity#GO:0019209;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;enzyme regulator activity#GO:0030234;protein binding#GO:0005515;molecular function activator activity#GO:0140677;enzyme activator activity#GO:0008047;protein kinase activator activity#GO:0030295;protein kinase regulator activity#GO:0019887;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;extracellular region#GO:0005576;signaling receptor complex#GO:0043235;plasma membrane#GO:0005886;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;vesicle#GO:0031982;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021 HUMAN|HGNC=5440|UniProtKB=P38484 P38484 IFNGR2 PTHR20859:SF46 INTERFERON/INTERLEUKIN RECEPTOR INTERFERON GAMMA RECEPTOR 2 transmembrane signaling receptor activity#GO:0004888;cytokine receptor activity#GO:0004896;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;immune receptor activity#GO:0140375 response to peptide#GO:1901652;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;cytokine-mediated signaling pathway#GO:0019221;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;response to cytokine#GO:0034097;response to chemical#GO:0042221;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 Interferon-gamma signaling pathway#P00035>IFNGR1#P00959;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Cytokine receptor#P00866;Interferon-gamma signaling pathway#P00035>IFNGR2#P00957 HUMAN|HGNC=30578|UniProtKB=Q8NEV8 Q8NEV8 EXPH5 PTHR21469:SF4 EXOPHILIN-5 EXOPHILIN-5 GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047 cell communication#GO:0007154;regulation of secretion#GO:0051046;localization#GO:0051179;regulation of secretion by cell#GO:1903530;intracellular signal transduction#GO:0035556;regulation of exocytosis#GO:0017157;positive regulation of secretion#GO:0051047;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;cellular response to stimulus#GO:0051716;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;establishment of localization#GO:0051234;regulation of transport#GO:0051049;regulation of localization#GO:0032879;transport#GO:0006810;vesicle-mediated transport#GO:0016192;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;cellular process#GO:0009987;multivesicular body sorting pathway#GO:0071985;positive regulation of secretion by cell#GO:1903532;positive regulation of biological process#GO:0048518;positive regulation of transport#GO:0051050;positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165 membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;vesicle#GO:0031982;intracellular vesicle#GO:0097708 HUMAN|HGNC=5428|UniProtKB=P01567 P01567 IFNA7 PTHR11691:SF69 TYPE I INTERFERON INTERFERON ALPHA-7 molecular function activator activity#GO:0140677;protein-containing complex binding#GO:0044877;protein binding#GO:0005515;cytokine activity#GO:0005125;cytokine receptor binding#GO:0005126;signaling receptor binding#GO:0005102;binding#GO:0005488;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018 response to peptide#GO:1901652;cell activation involved in immune response#GO:0002263;B cell activation involved in immune response#GO:0002312;type I interferon-mediated signaling pathway#GO:0060337;immune system process#GO:0002376;response to stimulus#GO:0050896;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;T cell activation#GO:0042110;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;B cell activation#GO:0042113;humoral immune response#GO:0006959;immune effector process#GO:0002252;natural killer cell activation#GO:0030101;cell surface receptor signaling pathway#GO:0007166;leukocyte activation involved in immune response#GO:0002366;defense response to other organism#GO:0098542;response to chemical#GO:0042221;lymphocyte activation#GO:0046649;response to cytokine#GO:0034097;T cell activation involved in immune response#GO:0002286;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;cellular process#GO:0009987;signal transduction#GO:0007165;lymphocyte activation involved in immune response#GO:0002285;defense response to symbiont#GO:0140546;cell communication#GO:0007154;response to nitrogen compound#GO:1901698;cytokine-mediated signaling pathway#GO:0019221;cell activation#GO:0001775;regulation of cellular process#GO:0050794;response to external biotic stimulus#GO:0043207;leukocyte activation#GO:0045321;cellular response to stimulus#GO:0051716;innate immune response#GO:0045087;defense response#GO:0006952;response to external stimulus#GO:0009605;multicellular organismal process#GO:0032501;adaptive immune response#GO:0002250;response to other organism#GO:0051707;biological regulation#GO:0065007;immune response#GO:0006955 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 cytokine#PC00083;interferon superfamily#PC00127 HUMAN|HGNC=12857|UniProtKB=Q9Y493 Q9Y493 ZAN PTHR11339:SF374 EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED ZONADHESIN extracellular matrix structural constituent#GO:0005201;structural molecule activity#GO:0005198 cellular anatomical structure#GO:0110165;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576 extracellular matrix protein#PC00102 HUMAN|HGNC=17851|UniProtKB=Q9Y3B8 Q9Y3B8 REXO2 PTHR11046:SF0 OLIGORIBONUCLEASE, MITOCHONDRIAL OLIGORIBONUCLEASE, MITOCHONDRIAL hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;3'-5' exonuclease activity#GO:0008408;catalytic activity, acting on RNA#GO:0140098;RNA nuclease activity#GO:0004540;3'-5'-RNA exonuclease activity#GO:0000175;exonuclease activity#GO:0004527;nuclease activity#GO:0004518;hydrolase activity#GO:0016787 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739 RNA metabolism protein#PC00031;endoribonuclease#PC00094 HUMAN|HGNC=1604|UniProtKB=P51677 P51677 CCR3 PTHR10489:SF649 CELL ADHESION MOLECULE C-C CHEMOKINE RECEPTOR TYPE 3 binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;protein binding#GO:0005515;cytokine receptor activity#GO:0004896;immune receptor activity#GO:0140375;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;cytokine binding#GO:0019955 biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124;taxis#GO:0042330;response to chemical#GO:0042221;cell migration#GO:0016477;immune response#GO:0006955;signal transduction#GO:0007165;cellular process#GO:0009987;response to stress#GO:0006950;response to external stimulus#GO:0009605;calcium-mediated signaling#GO:0019722;defense response#GO:0006952;signaling#GO:0023052;locomotion#GO:0040011;response to stimulus#GO:0050896;cell motility#GO:0048870;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell chemotaxis#GO:0060326;regulation of biological quality#GO:0065008;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;chemotaxis#GO:0006935;inflammatory response#GO:0006954;positive regulation of cytosolic calcium ion concentration#GO:0007204;cellular response to chemical stimulus#GO:0070887;immune system process#GO:0002376 cellular anatomical structure#GO:0110165;cell surface#GO:0009986;cytoplasm#GO:0005737;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;side of membrane#GO:0098552;intracellular anatomical structure#GO:0005622;external side of plasma membrane#GO:0009897 cell adhesion molecule#PC00069 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CHKR#P00854 HUMAN|HGNC=12791|UniProtKB=Q14191 Q14191 WRN PTHR13710:SF166 DNA HELICASE RECQ FAMILY MEMBER BIFUNCTIONAL 3'-5' EXONUCLEASE_ATP-DEPENDENT HELICASE WRN ATP-dependent activity#GO:0140657;ATP-dependent activity, acting on DNA#GO:0008094;macromolecular conformation isomerase activity#GO:0120543;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;isomerase activity#GO:0016853;3'-5' DNA helicase activity#GO:0043138;DNA helicase activity#GO:0003678;helicase activity#GO:0004386;catalytic activity, acting on DNA#GO:0140097 cellular process#GO:0009987;response to stress#GO:0006950;organelle organization#GO:0006996;nucleobase-containing compound metabolic process#GO:0006139;DNA damage response#GO:0006974;DNA recombination#GO:0006310;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;telomere maintenance#GO:0000723;double-strand break repair#GO:0006302;chromosome organization#GO:0051276;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;double-strand break repair via homologous recombination#GO:0000724;cellular response to stimulus#GO:0051716;DNA replication#GO:0006260;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;recombinational repair#GO:0000725;telomere organization#GO:0032200 intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membraneless organelle#GO:0043228;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 DNA metabolism protein#PC00009;DNA helicase#PC00011 p53 pathway#P00059>WRN#P04617 HUMAN|HGNC=16971|UniProtKB=Q8WU20 Q8WU20 FRS2 PTHR21258:SF40 DOCKING PROTEIN RELATED FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 2 enzyme binding#GO:0019899;protein kinase binding#GO:0019901;transmembrane receptor protein tyrosine kinase adaptor activity#GO:0005068;protein tyrosine kinase binding#GO:1990782;signaling receptor binding#GO:0005102;binding#GO:0005488;kinase binding#GO:0019900;protein-macromolecule adaptor activity#GO:0030674;signaling adaptor activity#GO:0035591;protein binding#GO:0005515;receptor tyrosine kinase binding#GO:0030971;signaling receptor complex adaptor activity#GO:0030159;growth factor receptor binding#GO:0070851;molecular adaptor activity#GO:0060090;fibroblast growth factor receptor binding#GO:0005104 cell surface receptor signaling pathway#GO:0007166;response to fibroblast growth factor#GO:0071774;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to fibroblast growth factor stimulus#GO:0044344;biological regulation#GO:0065007;fibroblast growth factor receptor signaling pathway#GO:0008543;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cellular response to growth factor stimulus#GO:0071363;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to endogenous stimulus#GO:0009719;signaling#GO:0023052;cellular response to endogenous stimulus#GO:0071495;response to growth factor#GO:0070848;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 cell-cell junction#GO:0005911;cellular anatomical structure#GO:0110165;cell junction#GO:0030054;anchoring junction#GO:0070161 scaffold/adaptor protein#PC00226 Angiogenesis#P00005>FRS-2#P00240;FGF signaling pathway#P00021>FRS2#P00635 HUMAN|HGNC=14237|UniProtKB=Q96NT3 Q96NT3 GUCD1 PTHR31400:SF1 GUANYLYL CYCLASE DOMAIN CONTAINING PROTEIN 1 GUCD1 PROTEIN GUCD1 guanylate cyclase#PC00114 HUMAN|HGNC=8090|UniProtKB=Q15646 Q15646 OASL PTHR11258:SF16 2-5 OLIGOADENYLATE SYNTHETASE 2'-5'-OLIGOADENYLATE SYNTHASE-LIKE PROTEIN transferase activity, transferring phosphorus-containing groups#GO:0016772;nucleotidyltransferase activity#GO:0016779;transferase activity#GO:0016740;catalytic activity#GO:0003824;RNA binding#GO:0003723;adenylyltransferase activity#GO:0070566;double-stranded RNA binding#GO:0003725;binding#GO:0005488;nucleic acid binding#GO:0003676 response to external biotic stimulus#GO:0043207;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;antiviral innate immune response#GO:0140374;cell communication#GO:0007154;response to virus#GO:0009615;cytokine-mediated signaling pathway#GO:0019221;biological regulation#GO:0065007;response to other organism#GO:0051707;immune response#GO:0006955;response to external stimulus#GO:0009605;defense response#GO:0006952;innate immune response#GO:0045087;biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052;response to stimulus#GO:0050896;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;defense response to virus#GO:0051607;response to peptide#GO:1901652;immune system process#GO:0002376;type I interferon-mediated signaling pathway#GO:0060337;response to chemical#GO:0042221;response to cytokine#GO:0034097;defense response to other organism#GO:0098542;defense response to symbiont#GO:0140546;signal transduction#GO:0007165;cellular process#GO:0009987;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;cell surface receptor signaling pathway#GO:0007166 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleus#GO:0005634;cytosol#GO:0005829;membrane#GO:0016020;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233 nucleotidyltransferase#PC00174;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=14015|UniProtKB=Q9BZC1 Q9BZC1 CELF4 PTHR24012:SF721 RNA BINDING PROTEIN CUGBP ELAV-LIKE FAMILY MEMBER 4 nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;RNA binding#GO:0003723 ribonucleoprotein complex biogenesis#GO:0022613;mRNA metabolic process#GO:0016071;cellular component organization#GO:0016043;mRNA splicing, via spliceosome#GO:0000398;regulation of biological process#GO:0050789;protein-containing complex assembly#GO:0065003;RNA metabolic process#GO:0016070;regulation of alternative mRNA splicing, via spliceosome#GO:0000381;spliceosomal complex assembly#GO:0000245;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;cellular component assembly#GO:0022607;mRNA splice site recognition#GO:0006376;RNA processing#GO:0006396;mRNA processing#GO:0006397;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;regulation of mRNA metabolic process#GO:1903311;protein-RNA complex organization#GO:0071826;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of mRNA splicing, via spliceosome#GO:0048024;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;protein-RNA complex assembly#GO:0022618;regulation of RNA metabolic process#GO:0051252;RNA splicing, via transesterification reactions#GO:0000375;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of mRNA processing#GO:0050684;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;biological regulation#GO:0065007;regulation of RNA splicing#GO:0043484;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;macromolecule biosynthetic process#GO:0009059;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulation of gene expression#GO:0010468 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634 RNA metabolism protein#PC00031 HUMAN|HGNC=26779|UniProtKB=A1L429 A1L429 GAGE12B PTHR14047:SF30 P ANTIGEN FAMILY MEMBER 5-RELATED G ANTIGEN 1-RELATED HUMAN|HGNC=2698|UniProtKB=P11182 P11182 DBT PTHR43178:SF18 LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED CHAIN ALPHA_KETOACID DEHYDROGENASE COMPLEX LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740 mitochondrion#GO:0005739;oxidoreductase complex#GO:1990204;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 transferase#PC00220;acetyltransferase#PC00038 HUMAN|HGNC=22951|UniProtKB=Q7Z3F1 Q7Z3F1 GPR155 PTHR22829:SF5 DEP DOMAIN PROTEIN LYSOSOMAL CHOLESTEROL SIGNALING PROTEIN negative regulation of BMP signaling pathway#GO:0030514;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;negative regulation of response to stimulus#GO:0048585;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;regulation of cellular response to growth factor stimulus#GO:0090287;biological regulation#GO:0065007;regulation of BMP signaling pathway#GO:0030510;negative regulation of cell communication#GO:0010648;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HUMAN|HGNC=5789|UniProtKB=A0A087WW87 A0A087WW87 IGKV2-40 PTHR23267:SF381 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN KAPPA VARIABLE 2-40-RELATED response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 protein-containing complex#GO:0032991 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=24175|UniProtKB=Q9P035 Q9P035 HACD3 PTHR11035:SF20 VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE 3 catalytic activity#GO:0003824;hydro-lyase activity#GO:0016836;carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829 fatty acid metabolic process#GO:0006631;sphingolipid biosynthetic process#GO:0030148;metabolic process#GO:0008152;sphingolipid metabolic process#GO:0006665;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;monocarboxylic acid biosynthetic process#GO:0072330;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058;fatty acid biosynthetic process#GO:0006633;oxoacid metabolic process#GO:0043436;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid biosynthetic process#GO:0046394;small molecule metabolic process#GO:0044281;very long-chain fatty acid metabolic process#GO:0000038 organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;membrane#GO:0016020 dehydratase#PC00091 HUMAN|HGNC=12732|UniProtKB=Q92558 Q92558 WASF1 PTHR12902:SF8 WASP-1 ACTIN-BINDING PROTEIN WASF1 protein-containing complex binding#GO:0044877;protein binding#GO:0005515;protein kinase A regulatory subunit binding#GO:0034237;binding#GO:0005488;protein kinase A binding#GO:0051018 regulation of actin filament organization#GO:0110053;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;organelle organization#GO:0006996;regulation of actin cytoskeleton organization#GO:0032956;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;regulation of actin filament-based process#GO:0032970;regulation of actin nucleation#GO:0051125;cellular component organization or biogenesis#GO:0071840;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of supramolecular fiber organization#GO:1902903;cellular component organization#GO:0016043;regulation of cellular process#GO:0050794;actin cytoskeleton organization#GO:0030036;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;actin filament-based process#GO:0030029;positive regulation of cellular component organization#GO:0051130;positive regulation of organelle organization#GO:0010638 intracellular anatomical structure#GO:0005622;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;cell projection#GO:0042995;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;lamellipodium#GO:0030027;cell leading edge#GO:0031252 actin or actin-binding cytoskeletal protein#PC00041;non-motor actin binding protein#PC00165;cytoskeletal protein#PC00085 HUMAN|HGNC=14255|UniProtKB=P55201 P55201 BRPF1 PTHR13793:SF85 PHD FINGER PROTEINS PEREGRIN molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;histone reader activity#GO:0140566;chromatin-protein adaptor activity#GO:0140463 regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;chromatin remodeling#GO:0006338;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of nucleobase-containing compound metabolic process#GO:0019219;chromatin organization#GO:0006325;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;cellular process#GO:0009987 membrane-bounded organelle#GO:0043227;acetyltransferase complex#GO:1902493;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;protein acetyltransferase complex#GO:0031248;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;chromosome#GO:0005694;histone acetyltransferase complex#GO:0000123;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;transferase complex#GO:1990234;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;chromatin#GO:0000785;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;zinc finger transcription factor#PC00244 HUMAN|HGNC=1782|UniProtKB=Q92772 Q92772 CDKL2 PTHR24056:SF241 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE-LIKE 2 phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=1093|UniProtKB=P07738 P07738 BPGM PTHR11931:SF11 PHOSPHOGLYCERATE MUTASE BISPHOSPHOGLYCERATE MUTASE phosphoglycerate mutase activity#GO:0004619;isomerase activity#GO:0016853;intramolecular phosphotransferase activity#GO:0016868;intramolecular transferase activity#GO:0016866;catalytic activity#GO:0003824 nucleobase-containing compound metabolic process#GO:0006139;nucleobase-containing compound catabolic process#GO:0034655;organophosphate metabolic process#GO:0019637;ribonucleotide catabolic process#GO:0009261;carbohydrate derivative metabolic process#GO:1901135;glycolytic process#GO:0006096;purine ribonucleoside triphosphate metabolic process#GO:0009205;ADP metabolic process#GO:0046031;energy derivation by oxidation of organic compounds#GO:0015980;nucleotide catabolic process#GO:0009166;generation of precursor metabolites and energy#GO:0006091;purine ribonucleoside diphosphate metabolic process#GO:0009179;catabolic process#GO:0009056;nucleoside phosphate catabolic process#GO:1901292;carbohydrate metabolic process#GO:0005975;nucleoside triphosphate metabolic process#GO:0009141;nucleoside phosphate metabolic process#GO:0006753;carbohydrate derivative catabolic process#GO:1901136;hexose metabolic process#GO:0019318;primary metabolic process#GO:0044238;purine ribonucleotide catabolic process#GO:0009154;purine nucleoside triphosphate metabolic process#GO:0009144;nucleoside diphosphate catabolic process#GO:0009134;organophosphate catabolic process#GO:0046434;ribonucleoside diphosphate catabolic process#GO:0009191;cellular respiration#GO:0045333;purine ribonucleoside diphosphate catabolic process#GO:0009181;aerobic respiration#GO:0009060;nucleoside diphosphate metabolic process#GO:0009132;pyridine-containing compound metabolic process#GO:0072524;purine nucleotide catabolic process#GO:0006195;nicotinamide nucleotide metabolic process#GO:0046496;cellular process#GO:0009987;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;purine-containing compound catabolic process#GO:0072523;glucose metabolic process#GO:0006006;nucleobase-containing small molecule metabolic process#GO:0055086;purine nucleoside diphosphate catabolic process#GO:0009137;metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;monosaccharide metabolic process#GO:0005996;ADP catabolic process#GO:0046032;small molecule metabolic process#GO:0044281;pyridine nucleotide catabolic process#GO:0019364;pyruvate metabolic process#GO:0006090;small molecule catabolic process#GO:0044282;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;phosphorus metabolic process#GO:0006793;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;ribonucleoside diphosphate metabolic process#GO:0009185;pyridine-containing compound catabolic process#GO:0072526;carbohydrate catabolic process#GO:0016052;nucleotide metabolic process#GO:0009117;oxoacid metabolic process#GO:0043436;purine nucleoside diphosphate metabolic process#GO:0009135;ribonucleotide metabolic process#GO:0009259 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 isomerase#PC00135;mutase#PC00160 Glycolysis#P00024>Phosphoglyceromutase#P00680 HUMAN|HGNC=70|UniProtKB=Q8NE71 Q8NE71 ABCF1 PTHR19211:SF126 ATP-BINDING TRANSPORT PROTEIN-RELATED ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 1 binding#GO:0005488;ATP binding#GO:0005524;small molecule binding#GO:0036094;anion binding#GO:0043168;nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;nucleotide binding#GO:0000166 translation elongation factor#PC00222 HUMAN|HGNC=29178|UniProtKB=Q9UPW0 Q9UPW0 FOXJ3 PTHR46078:SF3 FORKHEAD BOX PROTEIN J2 FAMILY MEMBER FORKHEAD BOX PROTEIN J3 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 winged helix/forkhead transcription factor#PC00246;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=26094|UniProtKB=Q7L4S7 Q7L4S7 ARMCX6 PTHR15712:SF6 ARMADILLO REPEAT CONTAINING PROTEIN PROTEIN ARMCX6 localization#GO:0051179;cellular localization#GO:0051641;microtubule-based transport#GO:0099111;axonal transport#GO:0098930;organelle localization#GO:0051640;microtubule-based movement#GO:0007018;establishment of organelle localization#GO:0051656;microtubule-based process#GO:0007017;mitochondrion localization#GO:0051646;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;transport#GO:0006810;intracellular transport#GO:0046907;organelle transport along microtubule#GO:0072384;cytoskeleton-dependent intracellular transport#GO:0030705;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;axo-dendritic transport#GO:0008088 mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HUMAN|HGNC=31685|UniProtKB=Q9NQA3 Q9NQA3 WASH6P PTHR23331:SF3 CXYORF1 WAS PROTEIN FAMILY HOMOLOG 4-RELATED localization within membrane#GO:0051668;actin filament-based process#GO:0030029;secretion by cell#GO:0032940;supramolecular fiber organization#GO:0097435;localization#GO:0051179;secretion#GO:0046903;cellular localization#GO:0051641;cellular component organization#GO:0016043;export from cell#GO:0140352;cytosolic transport#GO:0016482;endocytic recycling#GO:0032456;actin cytoskeleton organization#GO:0030036;actin nucleation#GO:0045010;transport#GO:0006810;intracellular transport#GO:0046907;endosomal transport#GO:0016197;vesicle-mediated transport to the plasma membrane#GO:0098876;actin filament organization#GO:0007015;exocytosis#GO:0006887;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;establishment of localization in cell#GO:0051649;Arp2/3 complex-mediated actin nucleation#GO:0034314;cellular process#GO:0009987;retrograde transport, endosome to Golgi#GO:0042147;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;vesicle-mediated transport#GO:0016192 vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;endosome#GO:0005768;recycling endosome#GO:0055037;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410 membrane traffic protein#PC00150 HUMAN|HGNC=19986|UniProtKB=P99999 P99999 CYCS PTHR11961:SF29 CYTOCHROME C CYTOCHROME C aerobic respiration#GO:0009060;oxidative phosphorylation#GO:0006119;ATP synthesis coupled electron transport#GO:0042773;energy derivation by oxidation of organic compounds#GO:0015980;cellular respiration#GO:0045333;generation of precursor metabolites and energy#GO:0006091;metabolic process#GO:0008152;aerobic electron transport chain#GO:0019646;mitochondrial electron transport, cytochrome c to oxygen#GO:0006123;mitochondrial electron transport, ubiquinol to cytochrome c#GO:0006122;mitochondrial ATP synthesis coupled electron transport#GO:0042775;cellular process#GO:0009987;respiratory electron transport chain#GO:0022904;electron transport chain#GO:0022900 mitochondrial intermembrane space#GO:0005758;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;organelle envelope#GO:0031967;mitochondrial envelope#GO:0005740;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 ATP synthesis#P02721>Cyt C#P02798;Apoptosis signaling pathway#P00006>Cytochrome C#P00322 HUMAN|HGNC=29591|UniProtKB=O95561 O95561 C1orf105 PTHR39410:SF1 RIKEN CDNA 4930558K02 GENE RIKEN CDNA 4930558K02 GENE HUMAN|HGNC=37275|UniProtKB=A4FU28 A4FU28 CTAGE9 PTHR23158:SF57 MELANOMA INHIBITORY ACTIVITY-RELATED CTAGE FAMILY MEMBER 15-RELATED vesicle-mediated transport#GO:0016192;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;establishment of localization#GO:0051234;establishment of protein localization to extracellular region#GO:0035592;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;transport#GO:0006810;Golgi vesicle transport#GO:0048193;export from cell#GO:0140352;protein localization to extracellular region#GO:0071692;secretion#GO:0046903;cellular localization#GO:0051641;protein secretion#GO:0009306;localization#GO:0051179;protein transport#GO:0015031;secretion by cell#GO:0032940;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888 endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;endoplasmic reticulum exit site#GO:0070971;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;membrane#GO:0016020;cytoplasm#GO:0005737;endomembrane system#GO:0012505 membrane traffic protein#PC00150 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HUMAN|HGNC=29041|UniProtKB=Q9UJP4 Q9UJP4 KLHL21 PTHR24412:SF255 KELCH PROTEIN KELCH-LIKE PROTEIN 21 enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498 cytoplasm#GO:0005737;cullin-RING ubiquitin ligase complex#GO:0031461;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;ubiquitin ligase complex#GO:0000151;Cul3-RING ubiquitin ligase complex#GO:0031463;catalytic complex#GO:1902494;transferase complex#GO:1990234 scaffold/adaptor protein#PC00226 HUMAN|HGNC=13189|UniProtKB=P21754 P21754 ZP3 PTHR11576:SF2 ZONA PELLUCIDA SPERM-BINDING PROTEIN 3 ZONA PELLUCIDA SPERM-BINDING PROTEIN 3 protein binding#GO:0005515;structural molecule activity#GO:0005198;binding#GO:0005488;enzyme binding#GO:0019899;extracellular matrix structural constituent#GO:0005201 cellular process#GO:0009987;positive regulation of biological process#GO:0048518;single fertilization#GO:0007338;oogenesis#GO:0048477;biological regulation#GO:0065007;regulation of reproductive process#GO:2000241;developmental process#GO:0032502;sperm-egg recognition#GO:0035036;cell-cell recognition#GO:0009988;cellular developmental process#GO:0048869;germ cell development#GO:0007281;regulation of biological process#GO:0050789;developmental process involved in reproduction#GO:0003006;fertilization#GO:0009566;cellular process involved in reproduction in multicellular organism#GO:0022412;cell development#GO:0048468;reproductive process#GO:0022414;gamete generation#GO:0007276;cell differentiation#GO:0030154;cell recognition#GO:0008037;sexual reproduction#GO:0019953;multicellular organismal reproductive process#GO:0048609;binding of sperm to zona pellucida#GO:0007339;anatomical structure development#GO:0048856 extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cellular anatomical structure#GO:0110165 HUMAN|HGNC=17111|UniProtKB=Q8TE59 Q8TE59 ADAMTS19 PTHR13723:SF197 ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 19 peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 cellular component organization#GO:0016043;primary metabolic process#GO:0044238;cellular process#GO:0009987;extracellular structure organization#GO:0043062;metabolic process#GO:0008152;proteolysis#GO:0006508;protein metabolic process#GO:0019538;extracellular matrix organization#GO:0030198;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;external encapsulating structure organization#GO:0045229 cellular anatomical structure#GO:0110165;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576 metalloprotease#PC00153 HUMAN|HGNC=29197|UniProtKB=Q9H7U1 Q9H7U1 CCSER2 PTHR22461:SF2 SERINE-RICH COILED-COIL DOMAIN-CONTAINING PROTEIN 2-RELATED SERINE-RICH COILED-COIL DOMAIN-CONTAINING PROTEIN 2 protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;microtubule binding#GO:0008017;binding#GO:0005488 cytoskeleton organization#GO:0007010;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;microtubule-based process#GO:0007017;microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;microtubule bundle formation#GO:0001578 microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 HUMAN|HGNC=17553|UniProtKB=Q96SE0 Q96SE0 ABHD1 PTHR10794:SF60 ABHYDROLASE DOMAIN-CONTAINING PROTEIN PROTEIN ABHD1 carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;hydrolase activity#GO:0016787 small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;monocarboxylic acid biosynthetic process#GO:0072330;lipid catabolic process#GO:0016042;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;fatty acid biosynthetic process#GO:0006633;biosynthetic process#GO:0009058;monocarboxylic acid catabolic process#GO:0072329;lipid biosynthetic process#GO:0008610;oxoacid metabolic process#GO:0043436;fatty acid catabolic process#GO:0009062;carboxylic acid biosynthetic process#GO:0046394;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;small molecule catabolic process#GO:0044282;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281 serine protease#PC00203;protease#PC00190 HUMAN|HGNC=15180|UniProtKB=Q8NGL7 Q8NGL7 OR4P4 PTHR48002:SF101 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 4P4 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=28397|UniProtKB=Q8TC56 Q8TC56 GARIN3 PTHR22574:SF2 FAMILY NOT NAMED GOLGI-ASSOCIATED RAB2 INTERACTOR PROTEIN 3 HUMAN|HGNC=17209|UniProtKB=Q9NRP7 Q9NRP7 STK36 PTHR22983:SF7 PROTEIN KINASE RELATED SERINE_THREONINE-PROTEIN KINASE 36 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;smoothened signaling pathway#GO:0007224;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 Hedgehog signaling pathway#P00025>Fused#P00686 HUMAN|HGNC=30389|UniProtKB=Q96A65 Q96A65 EXOC4 PTHR14146:SF4 EXOCYST COMPLEX COMPONENT 4 EXOCYST COMPLEX COMPONENT 4 transport#GO:0006810;establishment of localization#GO:0051234;exocytosis#GO:0006887;synaptic signaling#GO:0099536;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;localization#GO:0051179;secretion#GO:0046903;secretion by cell#GO:0032940;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;anterograde trans-synaptic signaling#GO:0098916;export from cell#GO:0140352;signaling#GO:0023052 cellular anatomical structure#GO:0110165;synapse#GO:0045202;plasma membrane bounded cell projection#GO:0120025;distal axon#GO:0150034;cell projection#GO:0042995;cell cortex#GO:0005938;intracellular anatomical structure#GO:0005622;site of polarized growth#GO:0030427;growth cone#GO:0030426;axon#GO:0030424;protein-containing complex#GO:0032991;exocyst#GO:0000145;cytoplasm#GO:0005737;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005;cell junction#GO:0030054;vesicle tethering complex#GO:0099023 membrane traffic protein#PC00150 HUMAN|HGNC=4518|UniProtKB=Q9HB89 Q9HB89 NMUR1 PTHR24243:SF109 G-PROTEIN COUPLED RECEPTOR NEUROMEDIN-U RECEPTOR 1 signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;molecular transducer activity#GO:0060089;G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888;neuropeptide receptor activity#GO:0008188 biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;neuropeptide signaling pathway#GO:0007218;cell communication#GO:0007154;phospholipase C-activating G protein-coupled receptor signaling pathway#GO:0007200;G protein-coupled receptor signaling pathway#GO:0007186 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021 HUMAN|HGNC=7858|UniProtKB=O60551 O60551 NMT2 PTHR11377:SF14 N-MYRISTOYL TRANSFERASE GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE 2 acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746 intracellular protein localization#GO:0008104;localization#GO:0051179;cellular localization#GO:0051641;localization within membrane#GO:0051668;cellular process#GO:0009987;macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 transferase#PC00220 HUMAN|HGNC=24491|UniProtKB=Q86XG9 Q86XG9 NBPF5P PTHR14199:SF29 NEUROBLASTOMA BREAKPOINT FAMILY MEMBER 6-LIKE PROTEIN NBPF FAMILY MEMBER NBPF4-RELATED HUMAN|HGNC=18704|UniProtKB=P41227 P41227 NAA10 PTHR23091:SF268 N-TERMINAL ACETYLTRANSFERASE N-ALPHA-ACETYLTRANSFERASE 10 acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;protein-N-terminal amino-acid acetyltransferase activity#GO:0004596;catalytic activity, acting on a protein#GO:0140096;protein N-acetyltransferase activity#GO:0034212;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein N-acyltransferase activity#GO:0140186;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238 cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;protein acetyltransferase complex#GO:0031248;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;acetyltransferase complex#GO:1902493 acetyltransferase#PC00038 HUMAN|HGNC=20914|UniProtKB=Q6QNY0 Q6QNY0 BLOC1S3 PTHR31974:SF2 BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 3 BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 3 cytoskeleton-dependent intracellular transport#GO:0030705;developmental maturation#GO:0021700;vesicle localization#GO:0051648;axo-dendritic transport#GO:0008088;vesicle cytoskeletal trafficking#GO:0099518;anterograde synaptic vesicle transport#GO:0048490;response to external stimulus#GO:0009605;establishment of localization#GO:0051234;cellular developmental process#GO:0048869;transport along microtubule#GO:0010970;transport#GO:0006810;developmental process#GO:0032502;vesicle transport along microtubule#GO:0047496;intracellular transport#GO:0046907;microtubule-based movement#GO:0007018;cellular response to stimulus#GO:0051716;anterograde axonal transport#GO:0008089;localization#GO:0051179;pigmentation#GO:0043473;organelle localization#GO:0051640;axonal transport#GO:0098930;organelle transport along microtubule#GO:0072384;cellular pigmentation#GO:0033059;establishment of vesicle localization#GO:0051650;synaptic vesicle localization#GO:0097479;developmental pigmentation#GO:0048066;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;synaptic vesicle transport#GO:0048489;microtubule-based process#GO:0007017;establishment of organelle localization#GO:0051656;response to stimulus#GO:0050896;cell differentiation#GO:0030154;cellular localization#GO:0051641;microtubule-based transport#GO:0099111 protein-containing complex#GO:0032991;BLOC-1 complex#GO:0031083;intracellular protein-containing complex#GO:0140535 HUMAN|HGNC=957|UniProtKB=P80723 P80723 BASP1 PTHR23212:SF0 BRAIN ACID SOLUBLE PROTEIN 1 BRAIN ACID SOLUBLE PROTEIN 1 transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712 negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HUMAN|HGNC=11824|UniProtKB=Q9BSI4 Q9BSI4 TINF2 PTHR15512:SF0 TERF1-INTERACTING NUCLEAR FACTOR 2 TERF1-INTERACTING NUCLEAR FACTOR 2 telomeric repeat DNA binding#GO:0042162;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;nucleic acid binding#GO:0003676;binding#GO:0005488 telomere organization#GO:0032200;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;regulation of DNA metabolic process#GO:0051052;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;nucleic acid metabolic process#GO:0090304;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;regulation of chromosome organization#GO:0033044;regulation of telomere maintenance#GO:0032204;chromosome organization#GO:0051276;telomere maintenance#GO:0000723;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;organelle organization#GO:0006996;telomere capping#GO:0016233;regulation of primary metabolic process#GO:0080090;regulation of telomere maintenance via telomere lengthening#GO:1904356;regulation of metabolic process#GO:0019222;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-DNA complex#GO:0032993;organelle#GO:0043226;chromosome#GO:0005694;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;chromosome, telomeric repeat region#GO:0140445;membrane-bounded organelle#GO:0043227;nuclear telomere cap complex#GO:0000783;intracellular organelle#GO:0043229;chromosome, telomeric region#GO:0000781;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513 HUMAN|HGNC=26583|UniProtKB=Q5H9M0 Q5H9M0 PWWP3B PTHR31333:SF3 PWWP DOMAIN-CONTAINING DNA REPAIR FACTOR 3 FAMILY MEMBER PWWP DOMAIN-CONTAINING DNA REPAIR FACTOR 3B DNA metabolism protein#PC00009 HUMAN|HGNC=13954|UniProtKB=O60814 O60814 H2BC12 PTHR23428:SF357 HISTONE H2B HISTONE H2B TYPE 1-K response to bacterium#GO:0009617;immune system process#GO:0002376;defense response to bacterium#GO:0042742;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;antimicrobial humoral response#GO:0019730;humoral immune response#GO:0006959;innate immune response#GO:0045087;antibacterial humoral response#GO:0019731;defense response#GO:0006952;response to external stimulus#GO:0009605;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;defense response to symbiont#GO:0140546;immune response#GO:0006955;defense response to other organism#GO:0098542;response to other organism#GO:0051707 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=25881|UniProtKB=Q8TBM8 Q8TBM8 DNAJB14 PTHR43908:SF4 AT29763P-RELATED DNAJ HOMOLOG SUBFAMILY B MEMBER 14 Hsp70 protein binding#GO:0030544;protein binding#GO:0005515;heat shock protein binding#GO:0031072;binding#GO:0005488;protein-folding chaperone binding#GO:0051087 protein metabolic process#GO:0019538;cellular response to stress#GO:0033554;cellular response to topologically incorrect protein#GO:0035967;response to stimulus#GO:0050896;response to topologically incorrect protein#GO:0035966;protein folding#GO:0006457;response to misfolded protein#GO:0051788;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;cellular response to misfolded protein#GO:0071218;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;response to stress#GO:0006950;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226 HUMAN|HGNC=14831|UniProtKB=Q8NGG5 Q8NGG5 OR8K1 PTHR48018:SF81 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 8K1 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;sensory perception of smell#GO:0007608;regulation of cellular process#GO:0050794;signaling#GO:0023052;G protein-coupled receptor signaling pathway#GO:0007186;sensory perception#GO:0007600;nervous system process#GO:0050877;cell communication#GO:0007154;signal transduction#GO:0007165;cellular process#GO:0009987;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=7427|UniProtKB=P00156 P00156 MT-CYB PTHR19271:SF42 CYTOCHROME B CYTOCHROME B electron transfer activity#GO:0009055;monoatomic cation transmembrane transporter activity#GO:0008324;proton transmembrane transporter activity#GO:0015078;catalytic activity#GO:0003824;transporter activity#GO:0005215;oxidoreductase activity, acting on diphenols and related substances as donors#GO:0016679;transmembrane transporter activity#GO:0022857;monoatomic ion transmembrane transporter activity#GO:0015075;oxidoreductase activity#GO:0016491;active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399 generation of precursor metabolites and energy#GO:0006091;metabolic process#GO:0008152;aerobic electron transport chain#GO:0019646;aerobic respiration#GO:0009060;oxidative phosphorylation#GO:0006119;ATP synthesis coupled electron transport#GO:0042773;cellular respiration#GO:0045333;energy derivation by oxidation of organic compounds#GO:0015980;mitochondrial electron transport, ubiquinol to cytochrome c#GO:0006122;mitochondrial ATP synthesis coupled electron transport#GO:0042775;cellular process#GO:0009987;respiratory electron transport chain#GO:0022904;electron transport chain#GO:0022900 transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;respiratory chain complex III#GO:0045275;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;membrane protein complex#GO:0098796;oxidoreductase complex#GO:1990204;membrane#GO:0016020;respiratory chain complex#GO:0098803;cytochrome complex#GO:0070069 HUMAN|HGNC=16052|UniProtKB=Q8N0Y2 Q8N0Y2 ZNF444 PTHR23226:SF150 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER PROTEIN 444 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=20163|UniProtKB=Q9H6D7 Q9H6D7 HAUS4 PTHR16219:SF3 AUGMIN SUBUNIT 4 FAMILY MEMBER HAUS AUGMIN-LIKE COMPLEX SUBUNIT 4 protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;microtubule binding#GO:0008017;binding#GO:0005488 organelle assembly#GO:0070925;microtubule cytoskeleton organization#GO:0000226;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;cell cycle#GO:0007049;cell cycle process#GO:0022402;centrosome cycle#GO:0007098;chromosome segregation#GO:0007059;cellular component organization or biogenesis#GO:0071840;spindle organization#GO:0007051;microtubule-based process#GO:0007017;microtubule organizing center organization#GO:0031023;spindle assembly#GO:0051225;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010 microtubule cytoskeleton#GO:0015630;HAUS complex#GO:0070652;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=10876|UniProtKB=Q9Y286 Q9Y286 SIGLEC7 PTHR12035:SF111 SIALIC ACID BINDING IMMUNOGLOBULIN-LIKE LECTIN SIALIC ACID-BINDING IG-LIKE LECTIN 7 ion binding#GO:0043167;carbohydrate derivative binding#GO:0097367;anion binding#GO:0043168;small molecule binding#GO:0036094;binding#GO:0005488;carboxylic acid binding#GO:0031406;organic acid binding#GO:0043177 cell adhesion#GO:0007155;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 cell adhesion molecule#PC00069;immunoglobulin superfamily cell adhesion molecule#PC00125 HUMAN|HGNC=24431|UniProtKB=O95678 O95678 KRT75 PTHR45616:SF13 GATA-TYPE DOMAIN-CONTAINING PROTEIN KERATIN, TYPE II CYTOSKELETAL 75 structural molecule activity#GO:0005198 cellular developmental process#GO:0048869;animal organ development#GO:0048513;cellular component organization or biogenesis#GO:0071840;epidermis development#GO:0008544;developmental process#GO:0032502;epithelial cell differentiation#GO:0030855;tissue development#GO:0009888;epidermal cell differentiation#GO:0009913;multicellular organismal process#GO:0032501;epithelium development#GO:0060429;cytoskeleton organization#GO:0007010;skin development#GO:0043588;organelle organization#GO:0006996;cellular process#GO:0009987;anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;keratinocyte differentiation#GO:0030216;animal gross anatomical part developmental process#GO:0160108;intermediate filament-based process#GO:0045103;intermediate filament organization#GO:0045109;cell differentiation#GO:0030154;intermediate filament cytoskeleton organization#GO:0045104;cellular component organization#GO:0016043 intracellular anatomical structure#GO:0005622;intermediate filament#GO:0005882;supramolecular fiber#GO:0099512;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;organelle#GO:0043226 HUMAN|HGNC=19162|UniProtKB=Q9P2P6 Q9P2P6 STARD9 PTHR47117:SF1 STAR-RELATED LIPID TRANSFER PROTEIN 9 STAR-RELATED LIPID TRANSFER PROTEIN 9 microtubule motor activity#GO:0003777;protein binding#GO:0005515;ATP-dependent activity#GO:0140657;microtubule binding#GO:0008017;polypeptide conformation or assembly isomerase activity#GO:0120544;binding#GO:0005488;isomerase activity#GO:0016853;cytoskeletal motor activity#GO:0003774;cytoskeletal protein binding#GO:0008092;macromolecular conformation isomerase activity#GO:0120543;tubulin binding#GO:0015631;catalytic activity#GO:0003824 microtubule cytoskeleton organization#GO:0000226;organelle assembly#GO:0070925;cell cycle process#GO:0022402;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;cell cycle#GO:0007049;microtubule-based process#GO:0007017;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;chromosome segregation#GO:0007059;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;cellular process#GO:0009987;spindle assembly#GO:0051225;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;centriole#GO:0005814;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;microtubule cytoskeleton#GO:0015630 HUMAN|HGNC=27683|UniProtKB=Q6UX46 Q6UX46 ALKAL2 PTHR28676:SF2 ALK AND LTK LIGAND 2-RELATED ALK AND LTK LIGAND 2 protein kinase activator activity#GO:0030295;receptor tyrosine kinase binding#GO:0030971;molecular function regulator activity#GO:0098772;kinase activator activity#GO:0019209;protein tyrosine kinase binding#GO:1990782;signaling receptor binding#GO:0005102;enzyme activator activity#GO:0008047;kinase regulator activity#GO:0019207;protein kinase regulator activity#GO:0019887;binding#GO:0005488;kinase binding#GO:0019900;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;protein binding#GO:0005515;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677 positive regulation of MAPK cascade#GO:0043410;regulation of MAPK cascade#GO:0043408;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;positive regulation of response to stimulus#GO:0048584;regulation of ERK1 and ERK2 cascade#GO:0070372;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of signaling#GO:0023056;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;positive regulation of ERK1 and ERK2 cascade#GO:0070374;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789 HUMAN|HGNC=5005|UniProtKB=P35914 P35914 HMGCL PTHR42738:SF1 HYDROXYMETHYLGLUTARYL-COA LYASE HYDROXYMETHYLGLUTARYL-COA LYASE, MITOCHONDRIAL lyase activity#GO:0016829;catalytic activity#GO:0003824;carbon-carbon lyase activity#GO:0016830 carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;small molecule catabolic process#GO:0044282;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;proteinogenic amino acid metabolic process#GO:0170039;lipid biosynthetic process#GO:0008610;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 lyase#PC00144 HUMAN|Ensembl=ENSG00000268861|UniProtKB=A0A590UK10 A0A590UK10 ARHGEF18 PTHR13944:SF23 AGAP007712-PA RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 18 guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;regulation of cell communication#GO:0010646;signaling#GO:0023052;regulation of cellular process#GO:0050794;regulation of Rho protein signal transduction#GO:0035023;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of small GTPase mediated signal transduction#GO:0051056;regulation of response to stimulus#GO:0048583;intracellular signaling cassette#GO:0141124;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;cellular process#GO:0009987;signal transduction#GO:0007165 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=19718|UniProtKB=Q9HBX9 Q9HBX9 RXFP1 PTHR24372:SF68 GLYCOPROTEIN HORMONE RECEPTOR RELAXIN RECEPTOR 1 transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;signaling receptor activity#GO:0038023;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089 cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;hormone-mediated signaling pathway#GO:0009755;cell communication#GO:0007154;response to endogenous stimulus#GO:0009719;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cellular response to hormone stimulus#GO:0032870;regulation of cellular process#GO:0050794;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;signaling#GO:0023052;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;response to hormone#GO:0009725;cellular process#GO:0009987;signal transduction#GO:0007165;response to chemical#GO:0042221;biological regulation#GO:0065007 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HUMAN|HGNC=1625|UniProtKB=P46094 P46094 XCR1 PTHR10489:SF730 CELL ADHESION MOLECULE CHEMOKINE XC RECEPTOR 1 G protein-coupled receptor activity#GO:0004930;immune receptor activity#GO:0140375;signaling receptor activity#GO:0038023;cytokine binding#GO:0019955;cytokine receptor activity#GO:0004896;molecular transducer activity#GO:0060089;protein binding#GO:0005515;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888 cellular process#GO:0009987;immune response#GO:0006955;signal transduction#GO:0007165;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;cell migration#GO:0016477;taxis#GO:0042330;response to chemical#GO:0042221;calcium-mediated signaling#GO:0019722;response to external stimulus#GO:0009605;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;locomotion#GO:0040011;signaling#GO:0023052;regulation of cellular process#GO:0050794;cell motility#GO:0048870;response to stimulus#GO:0050896;chemotaxis#GO:0006935;immune system process#GO:0002376;cellular response to chemical stimulus#GO:0070887;positive regulation of cytosolic calcium ion concentration#GO:0007204;intracellular signal transduction#GO:0035556;regulation of biological quality#GO:0065008;cell chemotaxis#GO:0060326;cell communication#GO:0007154 cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020;plasma membrane#GO:0005886;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552 cell adhesion molecule#PC00069 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CHKR#P00854 HUMAN|HGNC=23213|UniProtKB=Q7Z7B1 Q7Z7B1 PIGW PTHR20661:SF0 PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN GLUCOSAMINYL-PHOSPHATIDYLINOSITOL-ACYLTRANSFERASE PIGW acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746 protein metabolic process#GO:0019538;organophosphate biosynthetic process#GO:0090407;glycolipid biosynthetic process#GO:0009247;phospholipid metabolic process#GO:0006644;glycolipid metabolic process#GO:0006664;phospholipid biosynthetic process#GO:0008654;liposaccharide metabolic process#GO:1903509;glycerolipid metabolic process#GO:0046486;GPI anchored protein biosynthesis#GO:0180046;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;lipid metabolic process#GO:0006629;GPI anchor metabolic process#GO:0006505;glycerophospholipid biosynthetic process#GO:0046474;metabolic process#GO:0008152;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;gene expression#GO:0010467;protein maturation#GO:0051604;GPI anchor biosynthetic process#GO:0006506;glycerophospholipid metabolic process#GO:0006650;glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;organophosphate metabolic process#GO:0019637 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 acyltransferase#PC00042;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=26550|UniProtKB=Q96M43 Q96M43 NBPF4 PTHR14199:SF29 NEUROBLASTOMA BREAKPOINT FAMILY MEMBER 6-LIKE PROTEIN NBPF FAMILY MEMBER NBPF4-RELATED HUMAN|HGNC=30667|UniProtKB=Q9UGT4 Q9UGT4 SUSD2 PTHR13802:SF63 MUCIN 4-RELATED SUSHI DOMAIN-CONTAINING PROTEIN 2 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HUMAN|HGNC=24910|UniProtKB=Q9NWL6 Q9NWL6 ASNSD1 PTHR45937:SF2 ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1 ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1 muscle tissue development#GO:0060537;connective tissue development#GO:0061448;animal organ development#GO:0048513;anatomical structure development#GO:0048856;striated muscle tissue development#GO:0014706;developmental process#GO:0032502;muscle organ development#GO:0007517;skeletal muscle organ development#GO:0060538;animal gross anatomical part developmental process#GO:0160108;tissue development#GO:0009888;muscle structure development#GO:0061061;skeletal muscle tissue development#GO:0007519 HUMAN|HGNC=12023|UniProtKB=P56180 P56180 TPTE PTHR12305:SF99 PHOSPHATASE WITH HOMOLOGY TO TENSIN PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE TPTE2-RELATED phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;protein phosphatase#PC00195 Hypoxia response via HIF activation#P00030>PTEN#P00824;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>PTEN#G04675;p53 pathway#P00059>PTEN#P01480;p53 pathway feedback loops 2#P04398>PTEN#P04658;p53 pathway#P00059>PTEN#G01579;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>PTEN#P00905;p53 pathway feedback loops 2#P04398>PTEN#G04714 HUMAN|HGNC=12605|UniProtKB=P58418 P58418 CLRN1 PTHR31548:SF4 CLARIN CLARIN-1 neuromuscular process#GO:0050905;sensory perception of mechanical stimulus#GO:0050954;sensory perception#GO:0007600;nervous system process#GO:0050877;sensory perception of sound#GO:0007605;multicellular organismal process#GO:0032501;system process#GO:0003008 HUMAN|HGNC=18832|UniProtKB=Q53GI3 Q53GI3 ZNF394 PTHR23226:SF3 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER PROTEIN 394 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=3053|UniProtKB=Q99645 Q99645 EPYC PTHR46269:SF3 EPIPHYCAN-RELATED EPIPHYCAN bone development#GO:0060348;multicellular organismal process#GO:0032501;tissue development#GO:0009888;animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502;anatomical structure development#GO:0048856;animal organ development#GO:0048513;multicellular organism development#GO:0007275;skeletal system development#GO:0001501;cartilage development#GO:0051216;connective tissue development#GO:0061448;system development#GO:0048731 extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical structure#GO:0110165 HUMAN|HGNC=10757|UniProtKB=P84101 P84101 SERF2 PTHR13596:SF2 SMALL EDRK-RICH FACTOR 1 SMALL EDRK-RICH FACTOR 2 HUMAN|HGNC=8711|UniProtKB=Q9UN71 Q9UN71 PCDHGB4 PTHR24028:SF117 CADHERIN-87A PROTOCADHERIN GAMMA-B4 cell adhesion#GO:0007155;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 cell adhesion molecule#PC00069;cadherin#PC00057 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HUMAN|HGNC=11233|UniProtKB=Q9UBP0 Q9UBP0 SPAST PTHR23074:SF173 AAA DOMAIN-CONTAINING SPASTIN ATP-dependent activity#GO:0140657;polypeptide conformation or assembly isomerase activity#GO:0120544;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP hydrolysis activity#GO:0016887;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;macromolecular conformation isomerase activity#GO:0120543;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;isomerase activity#GO:0016853;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity, acting on a protein#GO:0140096 axonogenesis#GO:0007409;neuron development#GO:0048666;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;central nervous system development#GO:0007417;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell morphogenesis#GO:0000902;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;cell projection morphogenesis#GO:0048858;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;cytoskeleton organization#GO:0007010;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;cellular process#GO:0009987;organelle organization#GO:0006996;neuron projection development#GO:0031175;system development#GO:0048731;microtubule cytoskeleton organization#GO:0000226;anatomical structure development#GO:0048856;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;developmental process#GO:0032502;central nervous system neuron differentiation#GO:0021953;neuron projection morphogenesis#GO:0048812;plasma membrane bounded cell projection organization#GO:0120036;multicellular organismal process#GO:0032501;axon development#GO:0061564 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;spindle#GO:0005819;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;microtubule cytoskeleton#GO:0015630 microtubule or microtubule-binding cytoskeletal protein#PC00157;non-motor microtubule binding protein#PC00166 HUMAN|HGNC=13549|UniProtKB=Q9P241 Q9P241 ATP10D PTHR24092:SF84 PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE PHOSPHOLIPID-TRANSPORTING ATPASE VD intramembrane lipid carrier activity#GO:0140303;ATP-dependent activity#GO:0140657;ATPase-coupled intramembrane lipid carrier activity#GO:0140326;transporter activity#GO:0005215;molecular carrier activity#GO:0140104;lipid carrier activity#GO:0005319 transport#GO:0006810;regulation of membrane lipid distribution#GO:0097035;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;macromolecule localization#GO:0033036;phospholipid transport#GO:0015914;phospholipid translocation#GO:0045332;membrane organization#GO:0061024;biological regulation#GO:0065007;lipid transport#GO:0006869;lipid localization#GO:0010876;regulation of biological quality#GO:0065008;localization#GO:0051179;cellular component organization#GO:0016043;lipid translocation#GO:0034204;organophosphate ester transport#GO:0015748 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227;primary active transporter#PC00068 HUMAN|HGNC=21965|UniProtKB=Q92546 Q92546 RGP1 PTHR12507:SF3 REDUCED GROWTH PHENOTYPE 1 RGP1, YEAST -RELATED RAB6A-GEF COMPLEX PARTNER PROTEIN 2 molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;guanyl-nucleotide exchange factor activity#GO:0005085 intracellular transport#GO:0046907;transport#GO:0006810;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;endosomal transport#GO:0016197;retrograde transport, endosome to Golgi#GO:0042147;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;cytosolic transport#GO:0016482 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;guanyl-nucleotide exchange factor complex#GO:0032045;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;intracellular protein-containing complex#GO:0140535;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588 HUMAN|HGNC=18871|UniProtKB=Q8IVH4 Q8IVH4 MMAA PTHR23408:SF3 METHYLMALONYL-COA MUTASE METHYLMALONIC ACIDURIA TYPE A PROTEIN, MITOCHONDRIAL ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 mutase#PC00160 HUMAN|HGNC=5126|UniProtKB=P09017 P09017 HOXC4 PTHR45771:SF9 HOMEOTIC PROTEIN DEFORMED HOMEOBOX PROTEIN HOX-C4 binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604;embryo development#GO:0009790;positive regulation of transcription by RNA polymerase II#GO:0045944;anterior/posterior pattern specification#GO:0009952;multicellular organism development#GO:0007275;embryonic morphogenesis#GO:0048598;animal organ development#GO:0048513;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;regulation of transcription by RNA polymerase II#GO:0006357;animal gross anatomical part developmental process#GO:0160108;chordate embryonic development#GO:0043009;skeletal system development#GO:0001501;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;skeletal system morphogenesis#GO:0048705;positive regulation of cellular process#GO:0048522;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;regionalization#GO:0003002;positive regulation of DNA-templated transcription#GO:0045893;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule metabolic process#GO:0060255;animal organ morphogenesis#GO:0009887;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;pattern specification process#GO:0007389;embryo development ending in birth or egg hatching#GO:0009792;embryonic organ development#GO:0048568;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252 intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 HUMAN|HGNC=14521|UniProtKB=Q8N831 Q8N831 TSPYL6 PTHR11875:SF29 TESTIS-SPECIFIC Y-ENCODED PROTEIN TESTIS-SPECIFIC Y-ENCODED-LIKE PROTEIN 6 binding#GO:0005488;chromatin binding#GO:0003682;histone binding#GO:0042393;protein binding#GO:0005515 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=27033|UniProtKB=Q2M3V2 Q2M3V2 SOWAHA PTHR14491:SF2 SOSONDOWAH, ISOFORM G ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN SOWAHA Ubiquitin proteasome pathway#P00060>E2#P01491 HUMAN|HGNC=21535|UniProtKB=Q9BZE4 Q9BZE4 GTPBP4 PTHR45759:SF1 NUCLEOLAR GTP-BINDING PROTEIN 1 GTP-BINDING PROTEIN 4 ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;RNA binding#GO:0003723;GTPase activity#GO:0003924;nucleic acid binding#GO:0003676;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818 ribosome biogenesis#GO:0042254;cellular component biogenesis#GO:0044085;ribosomal large subunit biogenesis#GO:0042273;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;ribonucleoprotein complex biogenesis#GO:0022613 intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232 HUMAN|HGNC=4093|UniProtKB=Q05329 Q05329 GAD2 PTHR45677:SF11 GLUTAMATE DECARBOXYLASE-RELATED GLUTAMATE DECARBOXYLASE 2 lyase activity#GO:0016829;carbon-carbon lyase activity#GO:0016830;catalytic activity#GO:0003824;carboxy-lyase activity#GO:0016831 carboxylic acid biosynthetic process#GO:0046394;cellular process#GO:0009987;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;amino acid metabolic process#GO:0006520;biosynthetic process#GO:0009058;proteinogenic amino acid metabolic process#GO:0170039;small molecule metabolic process#GO:0044281;small molecule biosynthetic process#GO:0044283;amino acid biosynthetic process#GO:0008652;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 decarboxylase#PC00089;metabolite interconversion enzyme#PC00262 Gamma-aminobutyric acid synthesis#P04384>Glutamate decarboxylase#P04482 HUMAN|HGNC=3519|UniProtKB=Q99502 Q99502 EYA1 PTHR10190:SF11 EYES ABSENT PROTEIN PHOSPHATASE EYA1 phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 anatomical structure development#GO:0048856;embryonic organ development#GO:0048568;animal organ morphogenesis#GO:0009887;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of DNA metabolic process#GO:0051054;cellular developmental process#GO:0048869;regulation of response to stress#GO:0080134;sensory organ development#GO:0007423;regulation of DNA repair#GO:0006282;regulation of response to stimulus#GO:0048583;developmental process#GO:0032502;multicellular organismal process#GO:0032501;positive regulation of response to stimulus#GO:0048584;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA repair#GO:0045739;biological regulation#GO:0065007;inner ear development#GO:0048839;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of metabolic process#GO:0009893;ear development#GO:0043583;regulation of cellular response to stress#GO:0080135;animal gross anatomical part developmental process#GO:0160108;sensory organ morphogenesis#GO:0090596;cell differentiation#GO:0030154;regulation of DNA metabolic process#GO:0051052;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;animal organ development#GO:0048513;embryonic morphogenesis#GO:0048598;multicellular organism development#GO:0007275;positive regulation of macromolecule metabolic process#GO:0010604;embryo development#GO:0009790;inner ear morphogenesis#GO:0042472;cellular process#GO:0009987;positive regulation of biological process#GO:0048518 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 histone modifying enzyme#PC00261 HUMAN|HGNC=44204|UniProtKB=B2RUZ4 B2RUZ4 SMIM1 PTHR38503:SF1 SMALL INTEGRAL MEMBRANE PROTEIN 1 SMALL INTEGRAL MEMBRANE PROTEIN 1 immune system process#GO:0002376;homeostasis of number of cells#GO:0048872;developmental process#GO:0032502;cellular developmental process#GO:0048869;anatomical structure development#GO:0048856;erythrocyte differentiation#GO:0030218;multicellular organismal-level homeostasis#GO:0048871;cellular process#GO:0009987;cell differentiation#GO:0030154;myeloid cell differentiation#GO:0030099;multicellular organismal process#GO:0032501;hemopoiesis#GO:0030097;homeostatic process#GO:0042592;cell development#GO:0048468 plasma membrane#GO:0005886;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=14677|UniProtKB=O75398 O75398 DEAF1 PTHR10237:SF15 DEFORMED EPIDERMAL AUTOREGULATORY FACTOR 1 HOMOLOG SUPPRESSIN DEFORMED EPIDERMAL AUTOREGULATORY FACTOR 1 HOMOLOG DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 zinc finger transcription factor#PC00244 HUMAN|HGNC=122|UniProtKB=P24666 P24666 ACP1 PTHR11717:SF34 LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE LOW MOLECULAR WEIGHT PHOSPHOTYROSINE PROTEIN PHOSPHATASE catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoprotein phosphatase activity#GO:0004721;protein tyrosine phosphatase activity#GO:0004725;hydrolase activity#GO:0016787 protein phosphatase#PC00195 HUMAN|HGNC=25452|UniProtKB=Q8N4L2 Q8N4L2 PIP4P2 PTHR21014:SF5 PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 4-PHOSPHATASE TYPE 2 PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 4-PHOSPHATASE catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578 dephosphorylation#GO:0016311;lipid modification#GO:0030258;phosphatidylinositol dephosphorylation#GO:0046856;metabolic process#GO:0008152;phosphatidylinositol metabolic process#GO:0046488;lipid metabolic process#GO:0006629;glycerolipid metabolic process#GO:0046486;glycerophospholipid metabolic process#GO:0006650;phospholipid metabolic process#GO:0006644;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;phosphate-containing compound metabolic process#GO:0006796;phospholipid dephosphorylation#GO:0046839 vesicle#GO:0031982;lysosome#GO:0005764;intracellular vesicle#GO:0097708;lytic vacuole membrane#GO:0098852;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endosome#GO:0005768;endosome membrane#GO:0010008;endocytic vesicle#GO:0030139;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;cell periphery#GO:0071944;lysosomal membrane#GO:0005765;vesicle membrane#GO:0012506;membrane#GO:0016020;plasma membrane#GO:0005886;vacuole#GO:0005773;cytoplasm#GO:0005737;phagocytic vesicle#GO:0045335;late endosome#GO:0005770;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;late endosome membrane#GO:0031902;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;lytic vacuole#GO:0000323;vacuolar membrane#GO:0005774 phosphatase#PC00181;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=12145|UniProtKB=A0A075B6U4 A0A075B6U4 TRAV7 PTHR19433:SF114 T-CELL RECEPTOR ALPHA CHAIN V REGION-RELATED T CELL RECEPTOR ALPHA VARIABLE 20-RELATED response to bacterium#GO:0009617;response to biotic stimulus#GO:0009607;response to other organism#GO:0051707;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to external stimulus#GO:0009605;response to stimulus#GO:0050896 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=11766|UniProtKB=P01137 P01137 TGFB1 PTHR11848:SF125 TGF-BETA FAMILY TRANSFORMING GROWTH FACTOR BETA-1 PROPROTEIN signaling receptor regulator activity#GO:0030545;cytokine activity#GO:0005125;receptor ligand activity#GO:0048018;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546 system development#GO:0048731;regulation of cell population proliferation#GO:0042127;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;response to transforming growth factor beta#GO:0071559;response to growth factor#GO:0070848;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;cellular response to transforming growth factor beta stimulus#GO:0071560;cellular developmental process#GO:0048869;developmental process#GO:0032502;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;cellular response to growth factor stimulus#GO:0071363;animal gross anatomical part developmental process#GO:0160108;signaling#GO:0023052;cellular response to endogenous stimulus#GO:0071495;cell differentiation#GO:0030154;response to stimulus#GO:0050896;circulatory system development#GO:0072359;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;multicellular organism development#GO:0007275;animal organ development#GO:0048513;cell surface receptor signaling pathway#GO:0007166;heart development#GO:0007507;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;signal transduction#GO:0007165;cellular process#GO:0009987;transforming growth factor beta receptor signaling pathway#GO:0007179 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 growth factor#PC00112 Gonadotropin-releasing hormone receptor pathway#P06664>TGFbeta#P06778;TGF-beta signaling pathway#P00052>TGFbeta#P01286 HUMAN|HGNC=26561|UniProtKB=Q8NEK5 Q8NEK5 ZNF548 PTHR24377:SF730 IP01015P-RELATED ZINC FINGER PROTEIN 548 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=26460|UniProtKB=Q96N16 Q96N16 JAKMIP1 PTHR18935:SF6 GOLGIN SUBFAMILY A MEMBER 4-LIKE ISOFORM X1 JANUS KINASE AND MICROTUBULE-INTERACTING PROTEIN 1 binding#GO:0005488;signaling receptor binding#GO:0005102;GABA receptor binding#GO:0050811;protein binding#GO:0005515 HUMAN|HGNC=20471|UniProtKB=O95777 O95777 LSM8 PTHR15588:SF9 LSM1 U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM8 mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 ribonucleoprotein complex#GO:1990904;precatalytic spliceosome#GO:0071011;intracellular organelle#GO:0043229;spliceosomal tri-snRNP complex#GO:0097526;spliceosomal snRNP complex#GO:0097525;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;spliceosomal complex#GO:0005681;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;U6 snRNP#GO:0005688;nuclear protein-containing complex#GO:0140513;Sm-like protein family complex#GO:0120114;small nuclear ribonucleoprotein complex#GO:0030532;nucleus#GO:0005634;U4/U6 x U5 tri-snRNP complex#GO:0046540;protein-containing complex#GO:0032991 RNA processing factor#PC00147;RNA splicing factor#PC00148 HUMAN|HGNC=16677|UniProtKB=Q92688 Q92688 ANP32B PTHR11375:SF2 ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32 ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32 FAMILY MEMBER B protein binding#GO:0005515;binding#GO:0005488;histone binding#GO:0042393 regulation of apoptotic process#GO:0042981;regulation of biological process#GO:0050789;regulation of programmed cell death#GO:0043067;biological regulation#GO:0065007;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=11062|UniProtKB=O43246 O43246 SLC7A4 PTHR43243:SF108 INNER MEMBRANE TRANSPORTER YGJI-RELATED CATIONIC AMINO ACID TRANSPORTER 4 amino acid transmembrane transporter activity#GO:0015171;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 transport#GO:0006810;amino acid transport#GO:0006865;localization#GO:0051179;establishment of localization#GO:0051234 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 secondary carrier transporter#PC00258;amino acid transporter#PC00046 HUMAN|HGNC=23235|UniProtKB=Q2KHN1 Q2KHN1 RNF151 PTHR15315:SF64 RING FINGER PROTEIN 41, 151 RING FINGER PROTEIN 151 ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824 macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056 endoplasmic reticulum tubular network#GO:0071782;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=3342|UniProtKB=Q05925 Q05925 EN1 PTHR24341:SF4 HOMEOBOX PROTEIN ENGRAILED HOMEOBOX PROTEIN ENGRAILED-1 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;nervous system development#GO:0007399;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;developmental process#GO:0032502;neuron differentiation#GO:0030182;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of biological process#GO:0050789;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119 Wnt signaling pathway#P00057>Wnt Target Genes#G01558 HUMAN|HGNC=14618|UniProtKB=Q8WTP9 Q8WTP9 XAGE3 PTHR14047:SF4 P ANTIGEN FAMILY MEMBER 5-RELATED X ANTIGEN FAMILY MEMBER 3 HUMAN|HGNC=14369|UniProtKB=P21128 P21128 ENDOU PTHR12439:SF40 PLACENTAL PROTEIN 11-RELATED URIDYLATE-SPECIFIC ENDORIBONUCLEASE catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;RNA endonuclease activity#GO:0004521;catalytic activity, acting on RNA#GO:0140098;nuclease activity#GO:0004518;endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540 post-transcriptional gene silencing#GO:0016441;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of metabolic process#GO:0009892;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=13853|UniProtKB=Q9BRR0 Q9BRR0 ZKSCAN3 PTHR23226:SF130 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER PROTEIN WITH KRAB AND SCAN DOMAINS 3 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=16122|UniProtKB=Q9H4H8 Q9H4H8 FAM83D PTHR16181:SF30 PROTEIN FAM83A-RELATED PROTEIN FAM83D binding#GO:0005488;kinase binding#GO:0019900;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;protein binding#GO:0005515 regulation of cell cycle phase transition#GO:1901987;cellular response to stimulus#GO:0051716;protein localization to organelle#GO:0033365;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of cell cycle G1/S phase transition#GO:1902806;cell communication#GO:0007154;localization#GO:0051179;macromolecule localization#GO:0033036;positive regulation of cellular process#GO:0048522;protein localization to microtubule cytoskeleton#GO:0072698;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of response to stimulus#GO:0048583;intracellular protein localization#GO:0008104;protein localization to cytoskeleton#GO:0044380;positive regulation of cell cycle process#GO:0090068;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signaling#GO:0023052;regulation of cell cycle#GO:0051726;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;regulation of TOR signaling#GO:0032006;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;regulation of ERK1 and ERK2 cascade#GO:0070372;positive regulation of cell cycle#GO:0045787;regulation of cell cycle process#GO:0010564;positive regulation of cell cycle G1/S phase transition#GO:1902808;regulation of MAPK cascade#GO:0043408 cytoskeleton#GO:0005856;spindle#GO:0005819;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;mitotic spindle pole#GO:0097431;spindle pole#GO:0000922;microtubule cytoskeleton#GO:0015630;cytosol#GO:0005829;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;mitotic spindle#GO:0072686;intracellular membraneless organelle#GO:0043232 HUMAN|HGNC=6608|UniProtKB=Q8NHJ6 Q8NHJ6 LILRB4 PTHR11738:SF200 MHC CLASS I NK CELL RECEPTOR LEUKOCYTE IMMUNOGLOBULIN-LIKE RECEPTOR SUBFAMILY B MEMBER 4 transmembrane signaling receptor activity#GO:0004888;immune receptor activity#GO:0140375;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;response to cytokine#GO:0034097;response to chemical#GO:0042221;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;immune response-regulating signaling pathway#GO:0002764;cellular response to stimulus#GO:0051716;response to peptide#GO:1901652;cell communication#GO:0007154;regulation of immune response#GO:0050776;cytokine-mediated signaling pathway#GO:0019221 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=51249|UniProtKB=M0QZC1 M0QZC1 RNF225 PTHR22791:SF1 RING-TYPE DOMAIN-CONTAINING PROTEIN RING FINGER PROTEIN 225 aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746 metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;protein modification process#GO:0036211;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=32940|UniProtKB=A6NCS4 A6NCS4 NKX2-6 PTHR24340:SF72 HOMEOBOX PROTEIN NKX HOMEOBOX PROTEIN NKX-2.6 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;developmental process#GO:0032502;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=33727|UniProtKB=Q658L1 Q658L1 SAXO2 PTHR31516:SF6 STABILIZER OF AXONEMAL MICROTUBULES 2 STABILIZER OF AXONEMAL MICROTUBULES 2 protein binding#GO:0005515;binding#GO:0005488;microtubule binding#GO:0008017;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092 axoneme#GO:0005930;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membrane-bounded organelle#GO:0043227;cilium#GO:0005929;intracellular organelle#GO:0043229;9+2 motile cilium#GO:0097729;axonemal microtubule#GO:0005879;cellular anatomical structure#GO:0110165;motile cilium#GO:0031514;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cytoplasmic microtubule#GO:0005881;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;sperm flagellum#GO:0036126;ciliary plasm#GO:0097014;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;centriole#GO:0005814;microtubule cytoskeleton#GO:0015630 non-motor microtubule binding protein#PC00166;cytoskeletal protein#PC00085 HUMAN|HGNC=53611|UniProtKB=P0DPD7 P0DPD7 EEF1AKMT4 PTHR12176:SF86 SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN EEF1A LYSINE METHYLTRANSFERASE 4 lysine N-methyltransferase activity#GO:0016278;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;N-methyltransferase activity#GO:0008170;protein-lysine N-methyltransferase activity#GO:0016279;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein methyltransferase activity#GO:0008276 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;post-transcriptional regulation of gene expression#GO:0010608;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;regulation of biological process#GO:0050789 transferase#PC00220;methyltransferase#PC00155;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=24415|UniProtKB=Q53S33 Q53S33 BOLA3 PTHR46188:SF1 BOLA-LIKE PROTEIN 3 BOLA-LIKE PROTEIN 3 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=14555|UniProtKB=Q9ULY5 Q9ULY5 CLEC4E PTHR22802:SF402 C-TYPE LECTIN SUPERFAMILY MEMBER C-TYPE LECTIN DOMAIN FAMILY 4 MEMBER E binding#GO:0005488;signaling receptor activity#GO:0038023;carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187;molecular transducer activity#GO:0060089 immune system process#GO:0002376;immune response#GO:0006955;response to stimulus#GO:0050896 membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;plasma membrane#GO:0005886 membrane traffic protein#PC00150 HUMAN|HGNC=10791|UniProtKB=Q13242 Q13242 SRSF9 PTHR23147:SF59 SERINE/ARGININE RICH SPLICING FACTOR SERINE_ARGININE-RICH SPLICING FACTOR 9 nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;nuclear body#GO:0016604;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;membraneless organelle#GO:0043228;nuclear speck#GO:0016607;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 RNA processing factor#PC00147;RNA splicing factor#PC00148;RNA metabolism protein#PC00031 HUMAN|HGNC=9187|UniProtKB=P24928 P24928 POLR2A PTHR19376:SF37 DNA-DIRECTED RNA POLYMERASE DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;termination of RNA polymerase II transcription#GO:0006369;macromolecule metabolic process#GO:0043170;DNA-templated transcription termination#GO:0006353;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467 organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;RNA polymerase II, core complex#GO:0005665;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;RNA polymerase II, holoenzyme#GO:0016591;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 HUMAN|HGNC=20920|UniProtKB=Q5VWC8 Q5VWC8 HACD4 PTHR11035:SF16 VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE 4 catalytic activity#GO:0003824;carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;hydro-lyase activity#GO:0016836 small molecule metabolic process#GO:0044281;very long-chain fatty acid metabolic process#GO:0000038;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid biosynthetic process#GO:0046394;oxoacid metabolic process#GO:0043436;lipid biosynthetic process#GO:0008610;fatty acid biosynthetic process#GO:0006633;biosynthetic process#GO:0009058;cellular process#GO:0009987;monocarboxylic acid biosynthetic process#GO:0072330;fatty acid metabolic process#GO:0006631;sphingolipid biosynthetic process#GO:0030148;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;membrane#GO:0016020;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 dehydratase#PC00091 HUMAN|HGNC=16967|UniProtKB=P56211 P56211 ARPP19 PTHR10358:SF4 ENDOSULFINE CAMP-REGULATED PHOSPHOPROTEIN 19 molecular function inhibitor activity#GO:0140678;protein phosphatase regulator activity#GO:0019888;enzyme regulator activity#GO:0030234;phosphatase inhibitor activity#GO:0019212;molecular function regulator activity#GO:0098772;phosphatase regulator activity#GO:0019208;enzyme inhibitor activity#GO:0004857;protein phosphatase inhibitor activity#GO:0004864 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=26537|UniProtKB=Q8N443 Q8N443 RIBC1 PTHR14517:SF11 RIB43A-RELATED RIB43A-LIKE WITH COILED-COILS PROTEIN 1 cytoskeletal protein#PC00085 HUMAN|HGNC=26087|UniProtKB=Q7Z4Q2 Q7Z4Q2 HEATR3 PTHR13347:SF1 HEAT REPEAT-CONTAINING PROTEIN 3 HEAT REPEAT-CONTAINING PROTEIN 3 protein localization to nucleus#GO:0034504;cellular component biogenesis#GO:0044085;macromolecule localization#GO:0033036;import into nucleus#GO:0051170;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;establishment of protein localization to organelle#GO:0072594;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;transport#GO:0006810;intracellular protein transport#GO:0006886;protein localization to organelle#GO:0033365;ribonucleoprotein complex biogenesis#GO:0022613;cellular localization#GO:0051641;localization#GO:0051179;protein import into nucleus#GO:0006606;protein transport#GO:0015031;nuclear transport#GO:0051169;ribosome biogenesis#GO:0042254;ribosomal large subunit biogenesis#GO:0042273;nucleocytoplasmic transport#GO:0006913 HUMAN|HGNC=14478|UniProtKB=Q9BYC9 Q9BYC9 MRPL20 PTHR10986:SF16 39S RIBOSOMAL PROTEIN L20 LARGE RIBOSOMAL SUBUNIT PROTEIN BL20M structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 protein-containing complex#GO:0032991;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;membraneless organelle#GO:0043228;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;ribosome#GO:0005840;mitochondrion#GO:0005739;mitochondrial ribosome#GO:0005761;intracellular anatomical structure#GO:0005622;organellar ribosome#GO:0000313;membrane-bounded organelle#GO:0043227;large ribosomal subunit#GO:0015934;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229 ribosomal protein#PC00202 HUMAN|HGNC=20620|UniProtKB=Q5GJ75 Q5GJ75 TNFAIP8L3 PTHR12757:SF5 TUMOR NECROSIS FACTOR INDUCED PROTEIN TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 8-LIKE PROTEIN 3 transporter activity#GO:0005215;lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104;lipid transfer activity#GO:0120013;phosphatidylinositol transfer activity#GO:0008526 regulation of signaling#GO:0023051;lipid localization#GO:0010876;regulation of intracellular signal transduction#GO:1902531;localization#GO:0051179;regulation of biological process#GO:0050789;regulation of cell communication#GO:0010646;organophosphate ester transport#GO:0015748;regulation of cellular process#GO:0050794;transport#GO:0006810;regulation of response to stimulus#GO:0048583;establishment of localization#GO:0051234;macromolecule localization#GO:0033036;phospholipid transport#GO:0015914;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;lipid transport#GO:0006869 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=23111|UniProtKB=Q6V1P9 Q6V1P9 DCHS2 PTHR24026:SF142 FAT ATYPICAL CADHERIN-RELATED PROTOCADHERIN-23 cellular process#GO:0009987;cell adhesion#GO:0007155;cell-cell adhesion#GO:0098609 anchoring junction#GO:0070161;adherens junction#GO:0005912;cellular anatomical structure#GO:0110165;cell junction#GO:0030054;cell-cell junction#GO:0005911 cadherin#PC00057 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HUMAN|HGNC=8821|UniProtKB=Q5T2W1 Q5T2W1 PDZK1 PTHR14191:SF6 PDZ DOMAIN CONTAINING PROTEIN NA(+)_H(+) EXCHANGE REGULATORY COFACTOR NHE-RF3-RELATED binding#GO:0005488;signaling receptor binding#GO:0005102;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;protein binding#GO:0005515;protein-membrane adaptor activity#GO:0043495 cellular process#GO:0009987;protein localization to plasma membrane#GO:0072659;protein localization to membrane#GO:0072657;macromolecule localization#GO:0033036;intracellular protein localization#GO:0008104;cellular localization#GO:0051641;localization#GO:0051179;localization within membrane#GO:0051668;protein localization to cell periphery#GO:1990778 plasma membrane#GO:0005886;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;apical part of cell#GO:0045177;cell periphery#GO:0071944;apical plasma membrane#GO:0016324;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HUMAN|HGNC=32393|UniProtKB=Q6ZNR0 Q6ZNR0 TMEM91 PTHR14768:SF2 UPF0338 PROTEIN TRANSMEMBRANE PROTEIN 91 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;membrane#GO:0016020 HUMAN|HGNC=17194|UniProtKB=Q9P0J0 Q9P0J0 NDUFA13 PTHR12966:SF0 NADH DEHYDROGENASE UBIQUINONE 1 ALPHA SUBCOMPLEX SUBUNIT 13 NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 13 catalytic complex#GO:1902494;respiratory chain complex I#GO:0045271;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;respiratory chain complex#GO:0098803;membrane protein complex#GO:0098796;membrane#GO:0016020;oxidoreductase complex#GO:1990204;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HUMAN|HGNC=13930|UniProtKB=Q8TD31 Q8TD31 CCHCR1 PTHR46822:SF1 COILED-COIL ALPHA-HELICAL ROD PROTEIN 1 COILED-COIL ALPHA-HELICAL ROD PROTEIN 1 intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907;protein export from nucleus#GO:0006611;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule localization#GO:0033036;nuclear transport#GO:0051169;protein transport#GO:0015031;nuclear export#GO:0051168;localization#GO:0051179;cellular localization#GO:0051641;nucleocytoplasmic transport#GO:0006913 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;centriole#GO:0005814;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=26348|UniProtKB=Q8IYM1 Q8IYM1 SEPTIN12 PTHR18884:SF66 SEPTIN SEPTIN-12 hydrolase activity, acting on acid anhydrides#GO:0016817;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787 cell division#GO:0051301;cellular process#GO:0009987;cell cycle process#GO:0022402;macromolecule localization#GO:0033036;cell cycle#GO:0007049;cytokinesis#GO:0000910;intracellular protein localization#GO:0008104;localization#GO:0051179;cytoskeleton-dependent cytokinesis#GO:0061640 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;cell periphery#GO:0071944;cell cortex#GO:0005938;microtubule cytoskeleton#GO:0015630;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cell division site#GO:0032153;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226 cytoskeletal protein#PC00085 HUMAN|HGNC=25929|UniProtKB=Q96JY0 Q96JY0 MAEL PTHR21358:SF4 PROTEIN MAELSTROM HOMOLOG PROTEIN MAELSTROM HOMOLOG transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 negative regulation of nucleobase-containing compound metabolic process#GO:0045934;RNA metabolic process#GO:0016070;negative regulation of DNA-templated transcription#GO:0045892;nucleic acid biosynthetic process#GO:0141187;nuclear division#GO:0000280;negative regulation of metabolic process#GO:0009892;gamete generation#GO:0007276;regulation of transcription by RNA polymerase II#GO:0006357;cell cycle process#GO:0022402;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;meiotic cell cycle process#GO:1903046;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;cellular component organization or biogenesis#GO:0071840;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;meiotic cell cycle#GO:0051321;male meiotic nuclear division#GO:0007140;RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;organelle organization#GO:0006996;regulation of RNA metabolic process#GO:0051252;multicellular organismal reproductive process#GO:0048609;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of DNA-templated transcription#GO:0006355;organelle fission#GO:0048285;sexual reproduction#GO:0019953;piRNA processing#GO:0034587;reproductive process#GO:0022414;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;primary metabolic process#GO:0044238;developmental process involved in reproduction#GO:0003006;nucleic acid metabolic process#GO:0090304;cell cycle#GO:0007049;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;meiotic nuclear division#GO:0140013;macromolecule metabolic process#GO:0043170;regulatory ncRNA processing#GO:0070918;spermatogenesis#GO:0007283;regulatory ncRNA-mediated gene silencing#GO:0031047;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;biosynthetic process#GO:0009058;regulation of RNA biosynthetic process#GO:2001141;male gamete generation#GO:0048232;regulation of nucleobase-containing compound metabolic process#GO:0019219;macromolecule biosynthetic process#GO:0009059;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;P granule#GO:0043186;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=33819|UniProtKB=Q6ZTB9 Q6ZTB9 ZNF833P PTHR16515:SF76 PR DOMAIN ZINC FINGER PROTEIN ZINC FINGER PROTEIN 711-RELATED regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218;zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=11801|UniProtKB=P04216 P04216 THY1 PTHR19226:SF2 THY-1 MEMBRANE GLYCOPROTEIN THY-1 MEMBRANE GLYCOPROTEIN enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695 cell surface receptor signaling pathway#GO:0007166;regulation of cell adhesion#GO:0030155;positive regulation of cellular component biogenesis#GO:0044089;regulation of cell-substrate adhesion#GO:0010810;biological regulation#GO:0065007;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165;cell communication#GO:0007154;regulation of cell-matrix adhesion#GO:0001952;regulation of cell junction assembly#GO:1901888;positive regulation of cellular component organization#GO:0051130;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of cellular component organization#GO:0051128;regulation of cellular component biogenesis#GO:0044087;signaling#GO:0023052;integrin-mediated signaling pathway#GO:0007229;positive regulation of cell adhesion#GO:0045785;cellular response to stimulus#GO:0051716;positive regulation of cell-substrate adhesion#GO:0010811;regulation of biological process#GO:0050789 cell periphery#GO:0071944;neuron projection#GO:0043005;membrane raft#GO:0045121;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;membrane microdomain#GO:0098857;external side of plasma membrane#GO:0009897;dendritic tree#GO:0097447;dendrite#GO:0030425;side of membrane#GO:0098552 cell adhesion molecule#PC00069 HUMAN|HGNC=1852|UniProtKB=P07199 P07199 CENPB PTHR19303:SF69 TRANSPOSON MAJOR CENTROMERE AUTOANTIGEN B DNA binding#GO:0003677;binding#GO:0005488;nucleic acid binding#GO:0003676 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 viral or transposable element protein#PC00237 HUMAN|HGNC=6175|UniProtKB=Q9NQX7 Q9NQX7 ITM2C PTHR10962:SF5 INTEGRAL TRANSMEMBRANE PROTEIN 2 INTEGRAL MEMBRANE PROTEIN 2C binding#GO:0005488;peptide binding#GO:0042277 regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of protein metabolic process#GO:0051246;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;negative regulation of cellular process#GO:0048523 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;cell periphery#GO:0071944;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=60|UniProtKB=O60706 O60706 ABCC9 PTHR24223:SF173 ATP-BINDING CASSETTE SUB-FAMILY C ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 9 potassium channel activity#GO:0005267;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261 transport#GO:0006810;monoatomic ion transport#GO:0006811;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;potassium ion transmembrane transport#GO:0071805;potassium ion transport#GO:0006813 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 ATP-binding cassette (ABC) transporter#PC00003 HUMAN|HGNC=6231|UniProtKB=Q14721 Q14721 KCNB1 PTHR11537:SF63 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY B MEMBER 1 molecular function regulator activity#GO:0098772;channel regulator activity#GO:0016247;ion channel regulator activity#GO:0099106;potassium channel regulator activity#GO:0015459;transporter regulator activity#GO:0141108 cellular process#GO:0009987;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;biological regulation#GO:0065007;transport#GO:0006810;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;action potential#GO:0001508;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008 leading edge membrane#GO:0031256;dendritic tree#GO:0097447;axon#GO:0030424;postsynaptic membrane#GO:0045211;dendrite#GO:0030425;cell projection membrane#GO:0031253;transmembrane transporter complex#GO:1902495;plasma membrane protein complex#GO:0098797;cell body#GO:0044297;postsynapse#GO:0098794;membrane protein complex#GO:0098796;plasma membrane bounded cell projection#GO:0120025;neuronal cell body#GO:0043025;cell projection#GO:0042995;synapse#GO:0045202;cellular anatomical structure#GO:0110165;synaptic membrane#GO:0097060;neuron projection membrane#GO:0032589;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;transporter complex#GO:1990351;cell junction#GO:0030054;cell periphery#GO:0071944;neuron projection#GO:0043005;membrane#GO:0016020;cell leading edge#GO:0031252;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane region#GO:0098590 voltage-gated ion channel#PC00241;ion channel#PC00133 HUMAN|HGNC=12640|UniProtKB=Q9P2Y5 Q9P2Y5 UVRAG PTHR15157:SF5 UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN organophosphate biosynthetic process#GO:0090407;process utilizing autophagic mechanism#GO:0061919;phosphatidylinositol phosphate biosynthetic process#GO:0046854;phospholipid biosynthetic process#GO:0008654;glycerolipid metabolic process#GO:0046486;catabolic process#GO:0009056;phospholipid metabolic process#GO:0006644;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474;lipid biosynthetic process#GO:0008610;glycerophospholipid metabolic process#GO:0006650;macroautophagy#GO:0016236;biosynthetic process#GO:0009058;organophosphate metabolic process#GO:0019637;glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987;autophagy#GO:0006914 transferase complex#GO:1990234;lytic vacuole#GO:0000323;extrinsic component of membrane#GO:0019898;membrane#GO:0016020;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;vacuole#GO:0005773;transferase complex, transferring phosphorus-containing groups#GO:0061695;endosome#GO:0005768;phosphatidylinositol 3-kinase complex, class III#GO:0035032;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=4463|UniProtKB=P46091 P46091 CMKLR2 PTHR24229:SF4 NEUROPEPTIDES RECEPTOR CHEMERIN-LIKE RECEPTOR 2 G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888;neuropeptide binding#GO:0042923;peptide binding#GO:0042277 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;neuropeptide signaling pathway#GO:0007218;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane#GO:0005886;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944 G-protein coupled receptor#PC00021 HUMAN|HGNC=4621|UniProtKB=P15170 P15170 GSPT1 PTHR23115:SF125 TRANSLATION FACTOR EUKARYOTIC PEPTIDE CHAIN RELEASE FACTOR GTP-BINDING SUBUNIT ERF3A hydrolase activity#GO:0016787;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817;translation factor activity#GO:0180051 biosynthetic process#GO:0009058;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;protein-containing complex disassembly#GO:0032984;protein biosynthetic process#GO:0160307;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;protein metabolic process#GO:0019538;cellular component disassembly#GO:0022411;translation#GO:0006412;translational termination#GO:0006415 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 translation factor#PC00223 HUMAN|HGNC=5784|UniProtKB=A2NJV5 A2NJV5 IGKV2-29 PTHR23267:SF518 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN KAPPA VARIABLE 2-29 response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=2687|UniProtKB=O60477 O60477 BRINP1 PTHR15564:SF7 MACPF DOMAIN-CONTAINING PROTEIN BMP_RETINOIC ACID-INDUCIBLE NEURAL-SPECIFIC PROTEIN 1 multicellular organism development#GO:0007275;negative regulation of cell cycle#GO:0045786;neuron differentiation#GO:0030182;response to lipid#GO:0033993;cellular response to lipid#GO:0071396;response to chemical#GO:0042221;nervous system development#GO:0007399;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;negative regulation of mitotic cell cycle#GO:0045930;animal gross anatomical part developmental process#GO:0160108;cellular response to chemical stimulus#GO:0070887;generation of neurons#GO:0048699;response to oxygen-containing compound#GO:1901700;cell differentiation#GO:0030154;response to stimulus#GO:0050896;central nervous system development#GO:0007417;regulation of cell cycle#GO:0051726;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;negative regulation of cellular process#GO:0048523;central nervous system neuron differentiation#GO:0021953;developmental process#GO:0032502;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;regulation of mitotic cell cycle#GO:0007346;anatomical structure development#GO:0048856;system development#GO:0048731;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716 dendritic tree#GO:0097447;dendrite#GO:0030425;intracellular anatomical structure#GO:0005622;neuron projection#GO:0043005;cell body#GO:0044297;cell projection#GO:0042995;neuronal cell body#GO:0043025;somatodendritic compartment#GO:0036477;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165 HUMAN|HGNC=11061|UniProtKB=Q8WY07 Q8WY07 SLC7A3 PTHR43243:SF20 INNER MEMBRANE TRANSPORTER YGJI-RELATED CATIONIC AMINO ACID TRANSPORTER 3 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;amino acid transmembrane transporter activity#GO:0015171 establishment of localization#GO:0051234;localization#GO:0051179;amino acid transport#GO:0006865;transport#GO:0006810 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 secondary carrier transporter#PC00258;amino acid transporter#PC00046 HUMAN|HGNC=16994|UniProtKB=Q13438 Q13438 OS9 PTHR15414:SF5 OS-9-RELATED PROTEIN OS-9 cellular response to unfolded protein#GO:0034620;response to endoplasmic reticulum stress#GO:0034976;cellular response to topologically incorrect protein#GO:0035967;localization#GO:0051179;cell communication#GO:0007154;protein metabolic process#GO:0019538;ERAD pathway#GO:0036503;intracellular signal transduction#GO:0035556;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;catabolic process#GO:0009056;protein localization to organelle#GO:0033365;regulation of cellular process#GO:0050794;macromolecule metabolic process#GO:0043170;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;endoplasmic reticulum unfolded protein response#GO:0030968;biological regulation#GO:0065007;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;response to unfolded protein#GO:0006986;cellular localization#GO:0051641;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signaling#GO:0023052;response to topologically incorrect protein#GO:0035966;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;response to stress#GO:0006950;signal transduction#GO:0007165;cellular process#GO:0009987;response to chemical#GO:0042221;proteasomal protein catabolic process#GO:0010498 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;endoplasmic reticulum lumen#GO:0005788;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 HUMAN|HGNC=17187|UniProtKB=Q99784 Q99784 OLFM1 PTHR23192:SF34 OLFACTOMEDIN-RELATED NOELIN cell communication#GO:0007154;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 structural protein#PC00211 HUMAN|HGNC=357|UniProtKB=O14862 O14862 AIM2 PTHR12200:SF17 INTERFERON-INDUCIBLE PROTEIN AIM2 FAMILY MEMBER INTERFERON-INDUCIBLE PROTEIN AIM2 nucleic acid binding#GO:0003676;binding#GO:0005488;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690 regulation of response to stimulus#GO:0048583;positive regulation of defense response#GO:0031349;positive regulation of immune response#GO:0050778;regulation of response to stress#GO:0080134;positive regulation of response to biotic stimulus#GO:0002833;positive regulation of response to external stimulus#GO:0032103;regulation of innate immune response#GO:0045088;positive regulation of innate immune response#GO:0045089;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;positive regulation of immune system process#GO:0002684;activation of innate immune response#GO:0002218;biological regulation#GO:0065007;regulation of response to external stimulus#GO:0032101;response to cytokine#GO:0034097;response to chemical#GO:0042221;positive regulation of response to stimulus#GO:0048584;regulation of defense response#GO:0031347;regulation of immune response#GO:0050776;immune system process#GO:0002376;response to peptide#GO:1901652;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;regulation of response to biotic stimulus#GO:0002831;regulation of immune system process#GO:0002682;response to stimulus#GO:0050896 nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;cytosol#GO:0005829;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;canonical inflammasome complex#GO:0061702;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 DNA-binding transcription factor#PC00218 HUMAN|HGNC=53833|UniProtKB=A0A2R8Y619 A0A2R8Y619 H2BK1 PTHR23428:SF393 HISTONE H2B HISTONE H2B TYPE 2-K1 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=19898|UniProtKB=Q7L1S5 Q7L1S5 CHST9 PTHR12137:SF6 CARBOHYDRATE SULFOTRANSFERASE CARBOHYDRATE SULFOTRANSFERASE 9 transferase activity, transferring sulphur-containing groups#GO:0016782;sulfotransferase activity#GO:0008146;transferase activity#GO:0016740;catalytic activity#GO:0003824 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;biosynthetic process#GO:0009058;proteoglycan biosynthetic process#GO:0030166;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;proteoglycan metabolic process#GO:0006029;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 transferase#PC00220 HUMAN|HGNC=15714|UniProtKB=P42704 P42704 LRPPRC PTHR46669:SF1 LEUCINE-RICH PPR MOTIF-CONTAINING PROTEIN, MITOCHONDRIAL LEUCINE-RICH PPR MOTIF-CONTAINING PROTEIN, MITOCHONDRIAL mRNA 3'-UTR binding#GO:0003730;RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;post-transcriptional regulation of gene expression#GO:0010608 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=7668|UniProtKB=Q15788 Q15788 NCOA1 PTHR10684:SF1 NUCLEAR RECEPTOR COACTIVATOR NUCLEAR RECEPTOR COACTIVATOR 1 binding#GO:0005488;transcription regulator activity#GO:0140110;protein binding#GO:0005515;RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629;DNA-binding transcription factor binding#GO:0140297;transcription coregulator activity#GO:0003712;transcription factor binding#GO:0008134;nuclear receptor binding#GO:0016922;transcription coactivator activity#GO:0003713 positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;response to hormone#GO:0009725;response to chemical#GO:0042221;positive regulation of macromolecule metabolic process#GO:0010604;cellular response to chemical stimulus#GO:0070887;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;regulation of transcription by RNA polymerase II#GO:0006357;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;cellular response to hormone stimulus#GO:0032870;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;cellular response to stimulus#GO:0051716;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 histone modifying enzyme#PC00261 HUMAN|HGNC=25215|UniProtKB=Q6UXB3 Q6UXB3 LYPD2 PTHR10036:SF11 CD59 GLYCOPROTEIN LY6_PLAUR DOMAIN-CONTAINING PROTEIN 2 HUMAN|HGNC=13872|UniProtKB=Q9Y4F9 Q9Y4F9 RIPOR2 PTHR15829:SF2 PROTEIN KINASE PKN/PRK1, EFFECTOR RHO FAMILY-INTERACTING CELL POLARIZATION REGULATOR 2 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=2703|UniProtKB=P42126 P42126 ECI1 PTHR11941:SF178 ENOYL-COA HYDRATASE-RELATED ENOYL-COA DELTA ISOMERASE 1, MITOCHONDRIAL isomerase activity#GO:0016853;intramolecular oxidoreductase activity#GO:0016860;catalytic activity#GO:0003824 monocarboxylic acid catabolic process#GO:0072329;carboxylic acid catabolic process#GO:0046395;lipid catabolic process#GO:0016042;cellular process#GO:0009987;lipid modification#GO:0030258;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;fatty acid oxidation#GO:0019395;fatty acid beta-oxidation#GO:0006635;lipid metabolic process#GO:0006629;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;small molecule catabolic process#GO:0044282;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;lipid oxidation#GO:0034440;fatty acid catabolic process#GO:0009062;oxoacid metabolic process#GO:0043436 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 metabolite interconversion enzyme#PC00262;lyase#PC00144;hydratase#PC00120 HUMAN|HGNC=27363|UniProtKB=Q6ZRS4 Q6ZRS4 ITPRID1 PTHR17469:SF14 SPERM SPECIFIC ANTIGEN 2-RELATED PROTEIN ITPRID1 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=12547|UniProtKB=O75795 O75795 UGT2B17 PTHR48043:SF156 EG:EG0003.4 PROTEIN-RELATED UDP-GLUCURONOSYLTRANSFERASE 2B17 hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;glucuronosyltransferase activity#GO:0015020;catalytic activity#GO:0003824;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757 hormone metabolic process#GO:0042445;biological regulation#GO:0065007;steroid metabolic process#GO:0008202;primary metabolic process#GO:0044238;cellular process#GO:0009987;regulation of hormone levels#GO:0010817;estrogen metabolic process#GO:0008210;regulation of biological quality#GO:0065008;metabolic process#GO:0008152;lipid metabolic process#GO:0006629 HUMAN|HGNC=29004|UniProtKB=O15015 O15015 ZNF646 PTHR24388:SF50 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 646 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=1481|UniProtKB=P04632 P04632 CAPNS1 PTHR46735:SF1 CALPAIN, SMALL SUBUNIT 1 A-RELATED CALPAIN SMALL SUBUNIT 1 endopeptidase complex#GO:1905369;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;peptidase complex#GO:1905368;caspase complex#GO:0008303;cytoplasm#GO:0005737 Huntington disease#P00029>Calpain#P00788 HUMAN|HGNC=17351|UniProtKB=Q99633 Q99633 PRPF18 PTHR13007:SF19 PRE-MRNA SPLICING FACTOR-RELATED PRE-MRNA-SPLICING FACTOR 18 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;mRNA splicing, via spliceosome#GO:0000398;ribonucleoprotein complex biogenesis#GO:0022613;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;protein-RNA complex assembly#GO:0022618;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;cellular component biogenesis#GO:0044085;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;cellular component assembly#GO:0022607;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;protein-RNA complex organization#GO:0071826;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933 spliceosomal snRNP complex#GO:0097525;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;spliceosomal tri-snRNP complex#GO:0097526;organelle#GO:0043226;cellular anatomical structure#GO:0110165;U2-type spliceosomal complex#GO:0005684;intracellular membrane-bounded organelle#GO:0043231;spliceosomal complex#GO:0005681;nuclear protein-containing complex#GO:0140513;U5 snRNP#GO:0005682;Sm-like protein family complex#GO:0120114;U4/U6 x U5 tri-snRNP complex#GO:0046540;protein-containing complex#GO:0032991;small nuclear ribonucleoprotein complex#GO:0030532;nucleus#GO:0005634 RNA splicing factor#PC00148 HUMAN|HGNC=8134|UniProtKB=Q99983 Q99983 OMD PTHR45712:SF3 AGAP008170-PA OSTEOMODULIN extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=23984|UniProtKB=Q9GZY0 Q9GZY0 NXF2 PTHR10662:SF46 NUCLEAR RNA EXPORT FACTOR NUCLEAR RNA EXPORT FACTOR 2 binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;poly(A)+ mRNA export from nucleus#GO:0016973;transport#GO:0006810;RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907;metabolic process#GO:0008152;biosynthetic process#GO:0009058;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;nitrogen compound transport#GO:0071705;macromolecule localization#GO:0033036;nuclear export#GO:0051168;nuclear transport#GO:0051169;cellular localization#GO:0051641;mRNA export from nucleus#GO:0006406;nucleic acid transport#GO:0050657;localization#GO:0051179;nucleocytoplasmic transport#GO:0006913;mRNA transport#GO:0051028;establishment of RNA localization#GO:0051236;RNA localization#GO:0006403;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 RNA metabolism protein#PC00031 HUMAN|HGNC=32463|UniProtKB=P0DKX0 P0DKX0 ZNF728 PTHR24377:SF739 IP01015P-RELATED ZINC FINGER PROTEIN 728 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=26131|UniProtKB=Q6UX41 Q6UX41 BTNL8 PTHR24100:SF108 BUTYROPHILIN BUTYROPHILIN-LIKE PROTEIN 8 binding#GO:0005488;signaling receptor binding#GO:0005102;protein binding#GO:0005515 regulation of cytokine production#GO:0001817;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;T cell receptor signaling pathway#GO:0050852;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;cellular response to stimulus#GO:0051716;regulation of macromolecule metabolic process#GO:0060255;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;immune response-activating cell surface receptor signaling pathway#GO:0002429;regulation of immune response#GO:0050776;cell communication#GO:0007154;positive regulation of immune system process#GO:0002684;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;activation of immune response#GO:0002253;cellular process#GO:0009987;antigen receptor-mediated signaling pathway#GO:0050851;regulation of multicellular organismal process#GO:0051239;cell surface receptor signaling pathway#GO:0007166;immune response-activating signaling pathway#GO:0002757;regulation of biological process#GO:0050789;immune response-regulating signaling pathway#GO:0002764;response to stimulus#GO:0050896;signaling#GO:0023052;immune system process#GO:0002376 external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell surface#GO:0009986 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=23230|UniProtKB=Q9GZZ9 Q9GZZ9 UBA5 PTHR10953:SF9 UBIQUITIN-ACTIVATING ENZYME E1 UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 5 ligase activity, forming carbon-sulfur bonds#GO:0016877;ATP-dependent activity#GO:0140657;sulfurtransferase activity#GO:0016783;thiosulfate-cyanide sulfurtransferase activity#GO:0004792;transferase activity, transferring sulphur-containing groups#GO:0016782;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;ubiquitin-like modifier activating enzyme activity#GO:0008641;transferase activity, transferring phosphorus-containing groups#GO:0016772;ligase activity#GO:0016874;catalytic activity, acting on a protein#GO:0140096 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152;post-translational protein modification#GO:0043687;protein modification process#GO:0036211;primary metabolic process#GO:0044238;protein modification by small protein conjugation#GO:0032446;cellular process#GO:0009987 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=1397|UniProtKB=Q13698 Q13698 CACNA1S PTHR45628:SF9 VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1 VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;channel activity#GO:0015267;voltage-gated calcium channel activity#GO:0005245;monoatomic cation channel activity#GO:0005261;calcium channel activity#GO:0005262;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803 monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;import across plasma membrane#GO:0098739;metal ion transport#GO:0030001;inorganic ion import across plasma membrane#GO:0099587;calcium ion transmembrane transport#GO:0070588;calcium ion import#GO:0070509;establishment of localization#GO:0051234;calcium ion transmembrane import into cytosol#GO:0097553;import into cell#GO:0098657;calcium ion transport#GO:0006816;inorganic cation import across plasma membrane#GO:0098659;transport#GO:0006810;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;calcium channel complex#GO:0034704;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane protein complex#GO:0098796;voltage-gated calcium channel complex#GO:0005891;membrane#GO:0016020;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;cation channel complex#GO:0034703 voltage-gated ion channel#PC00241 5HT2 type receptor mediated signaling pathway#P04374>Ca2+ channel#P04411;Alzheimer disease-amyloid secretase pathway#P00003>L-type calcium channels#P00082;Oxytocin receptor mediated signaling pathway#P04391>Ca2+ channel#P04535;Beta2 adrenergic receptor signaling pathway#P04378>Ca2+ channel#P04445;Beta1 adrenergic receptor signaling pathway#P04377>Ca2+ channel#P04438;Nicotinic acetylcholine receptor signaling pathway#P00044>Ca2+ channel#P01096;Gonadotropin-releasing hormone receptor pathway#P06664>L-type Ca2+#P06812 HUMAN|HGNC=25996|UniProtKB=Q6P6C2 Q6P6C2 ALKBH5 PTHR32074:SF2 RNA DEMETHYLASE ALKBH5 RNA DEMETHYLASE ALKBH5 dioxygenase activity#GO:0051213;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;catalytic activity, acting on RNA#GO:0140098;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;oxidoreductase activity#GO:0016491;demethylase activity#GO:0032451 positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;RNA destabilization#GO:0050779;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of mRNA metabolic process#GO:1903311;mRNA destabilization#GO:0061157;positive regulation of mRNA metabolic process#GO:1903313;regulation of mRNA stability#GO:0043488;negative regulation of metabolic process#GO:0009892;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;regulation of biological quality#GO:0065008;positive regulation of metabolic process#GO:0009893;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;positive regulation of catabolic process#GO:0009896;regulation of biosynthetic process#GO:0009889;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of mRNA catabolic process#GO:0061014;regulation of RNA metabolic process#GO:0051252;regulation of RNA stability#GO:0043487 intracellular membraneless organelle#GO:0043232;nuclear body#GO:0016604;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;membraneless organelle#GO:0043228;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nuclear speck#GO:0016607;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 RNA processing factor#PC00147 HUMAN|HGNC=23759|UniProtKB=Q96I13 Q96I13 ABHD8 PTHR42886:SF83 RE40534P-RELATED PROTEIN ABHD8 acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity#GO:0003824;glycerophospholipase activity#GO:0004620;transferase activity#GO:0016740;phospholipase activity#GO:0120569;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;lipase activity#GO:0016298;acyltransferase activity#GO:0016746;carboxylic ester hydrolase activity#GO:0052689 chemical homeostasis#GO:0048878;lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474;metabolic process#GO:0008152;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;organophosphate metabolic process#GO:0019637;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;glycerophospholipid metabolic process#GO:0006650;organophosphate biosynthetic process#GO:0090407;primary metabolic process#GO:0044238;lipid homeostasis#GO:0055088;phosphorus metabolic process#GO:0006793;homeostatic process#GO:0042592;phospholipid metabolic process#GO:0006644;phospholipid biosynthetic process#GO:0008654;glycerolipid metabolic process#GO:0046486 HUMAN|HGNC=5177|UniProtKB=O95081 O95081 AGFG2 PTHR46134:SF4 DRONGO, ISOFORM F ARF-GAP DOMAIN AND FG REPEAT-CONTAINING PROTEIN 2 anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;cell development#GO:0048468;cellular process involved in reproduction in multicellular organism#GO:0022412;intermediate filament cytoskeleton organization#GO:0045104;cell differentiation#GO:0030154;gamete generation#GO:0007276;intermediate filament organization#GO:0045109;acrosome assembly#GO:0001675;intermediate filament-based process#GO:0045103;spermatid differentiation#GO:0048515;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;endomembrane system organization#GO:0010256;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;cellular anatomical entity morphogenesis#GO:0032989;anatomical structure formation involved in morphogenesis#GO:0048646;vesicle organization#GO:0016050;cellular component organization or biogenesis#GO:0071840;germ cell development#GO:0007281;developmental process involved in reproduction#GO:0003006;reproductive process#GO:0022414;sexual reproduction#GO:0019953;spermatid development#GO:0007286;organelle assembly#GO:0070925;cellular component assembly involved in morphogenesis#GO:0010927;supramolecular fiber organization#GO:0097435;multicellular organismal reproductive process#GO:0048609;anatomical structure development#GO:0048856;male gamete generation#GO:0048232;spermatogenesis#GO:0007283;developmental process#GO:0032502;cellular developmental process#GO:0048869;nucleus organization#GO:0006997 membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708 HUMAN|HGNC=19858|UniProtKB=Q86TV6 Q86TV6 TTC7B PTHR23083:SF365 TETRATRICOPEPTIDE REPEAT PROTEIN, TPR TETRATRICOPEPTIDE REPEAT PROTEIN 7B glycerophospholipid metabolic process#GO:0006650;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058;organophosphate metabolic process#GO:0019637;macromolecule localization#GO:0033036;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;intracellular protein localization#GO:0008104;metabolic process#GO:0008152;protein localization to cell periphery#GO:1990778;glycerophospholipid biosynthetic process#GO:0046474;lipid metabolic process#GO:0006629;glycerolipid metabolic process#GO:0046486;phospholipid biosynthetic process#GO:0008654;phospholipid metabolic process#GO:0006644;protein localization to membrane#GO:0072657;protein localization to plasma membrane#GO:0072659;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;localization#GO:0051179;cellular localization#GO:0051641;organophosphate biosynthetic process#GO:0090407;phosphatidylinositol phosphate biosynthetic process#GO:0046854;localization within membrane#GO:0051668 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 HUMAN|HGNC=48334|UniProtKB=A6NHP3 A6NHP3 SPDYE2B PTHR31156:SF15 WBSCR19-LIKE PROTEIN SPEEDY PROTEIN E10-RELATED HUMAN|HGNC=16115|UniProtKB=Q8WWY7 Q8WWY7 WFDC12 PTHR19441:SF42 WAP four-disulfide core domain protein WAP FOUR-DISULFIDE CORE DOMAIN PROTEIN 12 molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866;enzyme inhibitor activity#GO:0004857;serine-type endopeptidase inhibitor activity#GO:0004867;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;peptidase regulator activity#GO:0061134;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414 response to bacterium#GO:0009617;immune system process#GO:0002376;defense response to bacterium#GO:0042742;response to stimulus#GO:0050896;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;antibacterial humoral response#GO:0019731;innate immune response#GO:0045087;defense response#GO:0006952;response to external stimulus#GO:0009605;humoral immune response#GO:0006959;antimicrobial humoral response#GO:0019730;defense response to other organism#GO:0098542;response to other organism#GO:0051707;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;defense response to symbiont#GO:0140546;immune response#GO:0006955 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease inhibitor#PC00191 HUMAN|HGNC=12010|UniProtKB=P09493 P09493 TPM1 PTHR19269:SF41 TROPOMYOSIN TROPOMYOSIN ALPHA-1 CHAIN actin filament binding#GO:0051015;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;binding#GO:0005488;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 muscle contraction#GO:0006936;heart contraction#GO:0060047;system process#GO:0003008;actin filament organization#GO:0007015;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;blood circulation#GO:0008015;multicellular organismal process#GO:0032501;cardiac muscle contraction#GO:0060048;actin filament-based process#GO:0030029;circulatory system process#GO:0003013;supramolecular fiber organization#GO:0097435;muscle system process#GO:0003012;heart process#GO:0003015;cellular component organization#GO:0016043;striated muscle contraction#GO:0006941;actin cytoskeleton organization#GO:0030036 polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;cytoskeleton#GO:0005856;actin filament#GO:0005884;intracellular organelle#GO:0043229;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;supramolecular complex#GO:0099080;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;actin cytoskeleton#GO:0015629 actin binding motor protein#PC00040 HUMAN|HGNC=33864|UniProtKB=Q3LI81 Q3LI81 KRTAP27-1 PTHR19051:SF34 KERATIN-ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 27-1 structural protein#PC00211 HUMAN|HGNC=11028|UniProtKB=P04920 P04920 SLC4A2 PTHR11453:SF14 ANION EXCHANGE PROTEIN ANION EXCHANGE PROTEIN 2 monoatomic ion transmembrane transporter activity#GO:0015075;active transmembrane transporter activity#GO:0022804;chloride transmembrane transporter activity#GO:0015108;bicarbonate transmembrane transporter activity#GO:0015106;antiporter activity#GO:0015297;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;secondary active transmembrane transporter activity#GO:0015291;monoatomic anion transmembrane transporter activity#GO:0008509 biological regulation#GO:0065007;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;establishment of localization#GO:0051234;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;chemical homeostasis#GO:0048878;transport#GO:0006810;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;homeostatic process#GO:0042592;intracellular monoatomic ion homeostasis#GO:0006873;transmembrane transport#GO:0055085;localization#GO:0051179;regulation of biological quality#GO:0065008;regulation of pH#GO:0006885;regulation of intracellular pH#GO:0051453 cell periphery#GO:0071944;basal plasma membrane#GO:0009925;membrane#GO:0016020;apical plasma membrane#GO:0016324;basal part of cell#GO:0045178;basolateral plasma membrane#GO:0016323;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;apical part of cell#GO:0045177 secondary carrier transporter#PC00258 HUMAN|HGNC=9680|UniProtKB=Q15256 Q15256 PTPRR PTHR46198:SF2 PROTEIN-TYROSINE-PHOSPHATASE RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE R enzyme binding#GO:0019899;protein kinase binding#GO:0019901;kinase binding#GO:0019900;binding#GO:0005488;phosphoprotein phosphatase activity#GO:0004721;protein binding#GO:0005515;hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096 cell communication#GO:0007154;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165 cell junction#GO:0030054;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cytoplasm#GO:0005737;cytosol#GO:0005829;membrane#GO:0016020;cell periphery#GO:0071944 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HUMAN|HGNC=4667|UniProtKB=Q9UKN8 Q9UKN8 GTF3C4 PTHR15496:SF2 GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 4 FAMILY GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 4 transcription regulator complex#GO:0005667;transcription factor TFIIIC complex#GO:0000127;protein-containing complex#GO:0032991 RNA metabolism protein#PC00031;general transcription factor#PC00259 HUMAN|HGNC=9778|UniProtKB=P20337 P20337 RAB3B PTHR47980:SF22 LD44762P RAS-RELATED PROTEIN RAB-3B protein binding#GO:0005515;binding#GO:0005488;myosin binding#GO:0017022;cytoskeletal protein binding#GO:0008092 export from cell#GO:0140352;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;secretion by cell#GO:0032940;exocytosis#GO:0006887;localization#GO:0051179;secretion#GO:0046903;establishment of localization#GO:0051234;transport#GO:0006810 intracellular vesicle#GO:0097708;vesicle#GO:0031982;synaptic vesicle#GO:0008021;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane#GO:0016020;secretory vesicle#GO:0099503;presynapse#GO:0098793;cell periphery#GO:0071944;transport vesicle#GO:0030133;endomembrane system#GO:0012505;plasma membrane#GO:0005886;cytoplasm#GO:0005737;cell junction#GO:0030054 HUMAN|HGNC=3048|UniProtKB=Q02413 Q02413 DSG1 PTHR24025:SF9 DESMOGLEIN FAMILY MEMBER DESMOGLEIN-1 cation binding#GO:0043169;metal ion binding#GO:0046872;protein binding#GO:0005515;calcium ion binding#GO:0005509;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167 cell-cell adhesion#GO:0098609;cell adhesion#GO:0007155;cellular process#GO:0009987 anchoring junction#GO:0070161;cellular anatomical structure#GO:0110165;cell junction#GO:0030054;cell-cell junction#GO:0005911 cadherin#PC00057 HUMAN|HGNC=5283|UniProtKB=P15515 P15515 HTN1 PTHR15057:SF2 STATHERIN HISTATIN-1 immune response#GO:0006955;defense response to symbiont#GO:0140546;cellular process#GO:0009987;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;response to other organism#GO:0051707;defense response to other organism#GO:0098542;humoral immune response#GO:0006959;cell killing#GO:0001906;antimicrobial humoral response#GO:0019730;response to external stimulus#GO:0009605;defense response#GO:0006952;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;immune system process#GO:0002376;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844 intracellular organelle#GO:0043229;extracellular region#GO:0005576;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=32550|UniProtKB=B2RXF5 B2RXF5 ZBTB42 PTHR24394:SF20 ZINC FINGER PROTEIN ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 42 DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=745|UniProtKB=P42127 P42127 ASIP PTHR16551:SF1 AGOUTI RELATED AGOUTI-SIGNALING PROTEIN protein binding#GO:0005515;molecular function activator activity#GO:0140677;hormone activity#GO:0005179;signaling receptor binding#GO:0005102;binding#GO:0005488;neuropeptide hormone activity#GO:0005184;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;neuropeptide receptor binding#GO:0071855;G protein-coupled receptor binding#GO:0001664 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HUMAN|HGNC=13200|UniProtKB=Q15942 Q15942 ZYX PTHR24212:SF1 ZYXIN/TRIP6 ZYXIN cell surface receptor signaling pathway#GO:0007166;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;cellular process#GO:0009987;signal transduction#GO:0007165;transforming growth factor beta receptor signaling pathway#GO:0007179;biological regulation#GO:0065007;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;response to transforming growth factor beta#GO:0071559;cellular response to growth factor stimulus#GO:0071363;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular response to transforming growth factor beta stimulus#GO:0071560;regulation of biological process#GO:0050789;integrin-mediated signaling pathway#GO:0007229;response to endogenous stimulus#GO:0009719;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;response to growth factor#GO:0070848 focal adhesion#GO:0005925;cell-substrate junction#GO:0030055;cellular anatomical structure#GO:0110165;organelle#GO:0043226;actin cytoskeleton#GO:0015629;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;actin filament bundle#GO:0032432;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;actomyosin#GO:0042641;membraneless organelle#GO:0043228;cell junction#GO:0030054;cytoskeleton#GO:0005856;stress fiber#GO:0001725 actin or actin-binding cytoskeletal protein#PC00041;cytoskeletal protein#PC00085 HUMAN|HGNC=31813|UniProtKB=Q6ZUM4 Q6ZUM4 ARHGAP27 PTHR23176:SF104 RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN RHO GTPASE-ACTIVATING PROTEIN 27 enzyme regulator activity#GO:0030234;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme activator activity#GO:0008047 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;signaling#GO:0023052;small GTPase-mediated signal transduction#GO:0007264;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 GTPase-activating protein#PC00257 PDGF signaling pathway#P00047>Rho#P01174 HUMAN|HGNC=44356|UniProtKB=A6NJY4 A6NJY4 TMEM238L PTHR28613:SF2 SI:CH211-232M10.4-RELATED TRANSMEMBRANE PROTEIN 238-LIKE HUMAN|HGNC=16690|UniProtKB=Q6PEY0 Q6PEY0 GJB7 PTHR11984:SF26 CONNEXIN GAP JUNCTION BETA-7 PROTEIN transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;channel activity#GO:0015267;wide pore channel activity#GO:0022829 cellular process#GO:0009987;regulation of biological process#GO:0050789;biological regulation#GO:0065007;signaling#GO:0023052;cell-cell signaling#GO:0007267;cell communication#GO:0007154 anchoring junction#GO:0070161;cell junction#GO:0030054;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane protein complex#GO:0098796;cell-cell junction#GO:0005911;membrane#GO:0016020;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 gap junction#PC00105;cell junction protein#PC00070 HUMAN|HGNC=6116|UniProtKB=P10914 P10914 IRF1 PTHR11949:SF3 INTERFERON REGULATORY FACTOR INTERFERON REGULATORY FACTOR 1 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 winged helix/forkhead transcription factor#PC00246;DNA-binding transcription factor#PC00218 HUMAN|HGNC=29478|UniProtKB=Q9GZN7 Q9GZN7 ROGDI PTHR13618:SF1 LEUCINE ZIPPER CONTAINING TRANSCRIPTION FACTOR LZF1 PROTEIN ROGDI HOMOLOG cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 basic leucine zipper transcription factor#PC00056;DNA-binding transcription factor#PC00218 HUMAN|HGNC=6300|UniProtKB=Q96KK3 Q96KK3 KCNS1 PTHR11537:SF61 VOLTAGE-GATED POTASSIUM CHANNEL DELAYED-RECTIFIER POTASSIUM CHANNEL REGULATORY SUBUNIT KCNS1 channel regulator activity#GO:0016247;molecular function regulator activity#GO:0098772;potassium channel regulator activity#GO:0015459;transporter regulator activity#GO:0141108;ion channel regulator activity#GO:0099106 action potential#GO:0001508;metal ion transport#GO:0030001;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813;transport#GO:0006810;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234 membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495 ion channel#PC00133;voltage-gated ion channel#PC00241 HUMAN|HGNC=10734|UniProtKB=O95754 O95754 SEMA4F PTHR11036:SF72 SEMAPHORIN SEMAPHORIN-4F molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;protein binding#GO:0005515;molecular function activator activity#GO:0140677;signaling receptor binding#GO:0005102;binding#GO:0005488 positive regulation of cellular process#GO:0048522;positive regulation of cell migration#GO:0030335;axon guidance#GO:0007411;axon development#GO:0061564;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;plasma membrane bounded cell projection organization#GO:0120036;multicellular organismal process#GO:0032501;developmental process#GO:0032502;regulation of cell migration#GO:0030334;neuron projection morphogenesis#GO:0048812;neuron projection guidance#GO:0097485;response to external stimulus#GO:0009605;positive regulation of locomotion#GO:0040017;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;locomotion#GO:0040011;regulation of cellular process#GO:0050794;chemotaxis#GO:0006935;system development#GO:0048731;regulation of cell motility#GO:2000145;cell communication#GO:0007154;anatomical structure development#GO:0048856;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;neuron projection development#GO:0031175;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;taxis#GO:0042330;response to chemical#GO:0042221;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell surface receptor signaling pathway#GO:0007166;cell projection morphogenesis#GO:0048858;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;positive regulation of cell motility#GO:2000147;cellular component organization#GO:0016043;signaling#GO:0023052;cell development#GO:0048468;cell differentiation#GO:0030154;response to stimulus#GO:0050896;cell projection organization#GO:0030030;cell morphogenesis#GO:0000902;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;neuron development#GO:0048666;axonogenesis#GO:0007409 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 membrane-bound signaling molecule#PC00152 HUMAN|HGNC=795|UniProtKB=Q13315 Q13315 ATM PTHR11139:SF130 ATAXIA TELANGIECTASIA MUTATED ATM -RELATED SERINE-PROTEIN KINASE ATM catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 intrinsic apoptotic signaling pathway in response to DNA damage#GO:0008630;regulation of telomere maintenance via telomere lengthening#GO:1904356;response to stress#GO:0006950;regulation of TOR signaling#GO:0032006;metabolic process#GO:0008152;negative regulation of TORC1 signaling#GO:1904262;double-strand break repair#GO:0006302;response to ionizing radiation#GO:0010212;regulation of DNA metabolic process#GO:0051052;signaling#GO:0023052;cellular response to radiation#GO:0071478;regulation of intracellular signal transduction#GO:1902531;positive regulation of cellular component organization#GO:0051130;cellular response to stress#GO:0033554;positive regulation of metabolic process#GO:0009893;positive regulation of organelle organization#GO:0010638;intrinsic apoptotic signaling pathway#GO:0097193;negative regulation of intracellular signal transduction#GO:1902532;response to radiation#GO:0009314;regulation of signal transduction#GO:0009966;nucleobase-containing compound metabolic process#GO:0006139;DNA repair#GO:0006281;regulation of chromosome organization#GO:0033044;apoptotic signaling pathway#GO:0097190;regulation of TORC1 signaling#GO:1903432;regulation of telomere maintenance#GO:0032204;nucleic acid metabolic process#GO:0090304;cell death#GO:0008219;negative regulation of TOR signaling#GO:0032007;cellular response to environmental stimulus#GO:0104004;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;negative regulation of signal transduction#GO:0009968;DNA metabolic process#GO:0006259;cellular response to abiotic stimulus#GO:0071214;negative regulation of biological process#GO:0048519;response to abiotic stimulus#GO:0009628;regulation of biological process#GO:0050789;apoptotic process#GO:0006915;regulation of organelle organization#GO:0033043;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;negative regulation of cell communication#GO:0010648;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of response to stimulus#GO:0048585;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;DNA damage response#GO:0006974;regulation of response to stimulus#GO:0048583;macromolecule metabolic process#GO:0043170;programmed cell death#GO:0012501;primary metabolic process#GO:0044238;positive regulation of DNA metabolic process#GO:0051054;cellular response to stimulus#GO:0051716;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646 nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 p53 pathway feedback loops 2#P04398>ATM#P04669;p53 pathway#P00059>ATM/ATR#P01481 HUMAN|HGNC=16266|UniProtKB=Q9BZV2 Q9BZV2 SLC19A3 PTHR10686:SF37 FOLATE TRANSPORTER THIAMINE TRANSPORTER 2 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 cellular process#GO:0009987;transport#GO:0006810;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227 HUMAN|HGNC=23804|UniProtKB=Q9BPW5 Q9BPW5 RASL11B PTHR45704:SF6 RAS-LIKE FAMILY MEMBER 11 RAS-LIKE PROTEIN FAMILY MEMBER 11B HUMAN|HGNC=6949|UniProtKB=Q14566 Q14566 MCM6 PTHR11630:SF73 DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER DNA REPLICATION LICENSING FACTOR MCM6 3'-5' DNA helicase activity#GO:0043138;isomerase activity#GO:0016853;DNA helicase activity#GO:0003678;helicase activity#GO:0004386;catalytic activity, acting on DNA#GO:0140097;macromolecular conformation isomerase activity#GO:0120543;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;DNA binding#GO:0003677;ATP-dependent activity, acting on DNA#GO:0008094;single-stranded DNA binding#GO:0003697;ATP-dependent activity#GO:0140657;binding#GO:0005488;nucleic acid binding#GO:0003676 response to stress#GO:0006950;double-strand break repair via break-induced replication#GO:0000727;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;cell cycle DNA replication#GO:0044786;DNA repair#GO:0006281;metabolic process#GO:0008152;nuclear DNA replication#GO:0033260;mitotic DNA replication#GO:1902969;DNA metabolic process#GO:0006259;DNA recombination#GO:0006310;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;mitotic cell cycle process#GO:1903047;double-strand break repair#GO:0006302;cell cycle#GO:0007049;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular response to stimulus#GO:0051716;cell cycle process#GO:0022402;double-strand break repair via homologous recombination#GO:0000724;DNA replication#GO:0006260;mitotic cell cycle#GO:0000278;response to stimulus#GO:0050896;recombinational repair#GO:0000725;cellular response to stress#GO:0033554;DNA-templated DNA replication#GO:0006261 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;MCM complex#GO:0042555;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 DNA metabolism protein#PC00009 HUMAN|HGNC=17718|UniProtKB=P67812 P67812 SEC11A PTHR10806:SF28 SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11 SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11A catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;catalytic activity#GO:0003824 metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;organelle membrane#GO:0031090;endoplasmic reticulum protein-containing complex#GO:0140534;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endopeptidase complex#GO:1905369;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasm#GO:0005737;peptidase complex#GO:1905368;membrane#GO:0016020 serine protease#PC00203 Endothelin signaling pathway#P00019>signal peptidase#P00573;Vasopressin synthesis#P04395>Signal Peptidase#P04589 HUMAN|HGNC=16461|UniProtKB=Q9Y2W2 Q9Y2W2 WBP11 PTHR13361:SF1 WW DOMAIN-BINDING PROTEIN 11 WW DOMAIN-BINDING PROTEIN 11 molecular function regulator activity#GO:0098772;protein phosphatase regulator activity#GO:0019888;enzyme regulator activity#GO:0030234;phosphatase regulator activity#GO:0019208 gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;RNA biosynthetic process#GO:0032774;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleic acid biosynthetic process#GO:0141187;RNA splicing#GO:0008380 HUMAN|HGNC=14735|UniProtKB=Q8NGD0 Q8NGD0 OR4M1 PTHR48002:SF103 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 4M1-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=28065|UniProtKB=Q2WGJ9 Q2WGJ9 FER1L6 PTHR12546:SF37 FER-1-LIKE FER-1-LIKE PROTEIN 6 endomembrane system organization#GO:0010256;membrane organization#GO:0061024;cellular component organization or biogenesis#GO:0071840;plasma membrane organization#GO:0007009;cellular process#GO:0009987;cellular component organization#GO:0016043 membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=30168|UniProtKB=Q15084 Q15084 PDIA6 PTHR45815:SF3 PROTEIN DISULFIDE-ISOMERASE A6 PROTEIN DISULFIDE-ISOMERASE A6 disulfide oxidoreductase activity#GO:0015036;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491;protein-disulfide reductase activity#GO:0015035;catalytic activity#GO:0003824;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cellular response to stress#GO:0033554;response to endoplasmic reticulum stress#GO:0034976;response to stress#GO:0006950;response to stimulus#GO:0050896 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 chaperone#PC00072 HUMAN|HGNC=9111|UniProtKB=Q9BQD1 Q9BQD1 PMCHL2 PTHR12091:SF1 MELANIN-CONCENTRATING HORMONE PRO-MCH-LIKE PROTEIN 1-RELATED protein binding#GO:0005515;neuropeptide receptor binding#GO:0071855;binding#GO:0005488;signaling receptor binding#GO:0005102;G protein-coupled receptor binding#GO:0001664 negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of trans-synaptic signaling#GO:0099177;regulation of cell communication#GO:0010646;biological regulation#GO:0065007;modulation of chemical synaptic transmission#GO:0050804;negative regulation of cellular process#GO:0048523;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;negative regulation of cell communication#GO:0010648 peptide hormone#PC00179;intercellular signal molecule#PC00207 HUMAN|HGNC=18035|UniProtKB=O95834 O95834 EML2 PTHR13720:SF50 WD-40 REPEAT PROTEIN ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 2 tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;microtubule binding#GO:0008017;protein binding#GO:0005515 organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226;cytoskeleton organization#GO:0007010;microtubule-based process#GO:0007017 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;spindle#GO:0005819;intracellular membraneless organelle#GO:0043232;mitotic spindle#GO:0072686;cellular anatomical structure#GO:0110165;organelle#GO:0043226;microtubule cytoskeleton#GO:0015630 microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=16522|UniProtKB=Q8N3Y3 Q8N3Y3 LARGE2 PTHR12270:SF23 GLYCOSYLTRANSFERASE-RELATED XYLOSYL- AND GLUCURONYLTRANSFERASE LARGE2 xylosyltransferase activity#GO:0042285;pentosyltransferase activity#GO:0016763;glucuronosyltransferase activity#GO:0015020;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740 carbohydrate derivative metabolic process#GO:1901135;protein O-linked glycosylation#GO:0006493;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;protein O-linked glycosylation via mannose#GO:0035269;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 glycosyltransferase#PC00111;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=19978|UniProtKB=Q8NBN7 Q8NBN7 RDH13 PTHR43157:SF59 PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED RETINOL DEHYDROGENASE 13 oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;alcohol dehydrogenase (NADP+) activity#GO:0008106;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;catalytic activity#GO:0003824 anatomical structure development#GO:0048856;isoprenoid metabolic process#GO:0006720;system development#GO:0048731;camera-type eye development#GO:0043010;terpenoid metabolic process#GO:0006721;animal organ morphogenesis#GO:0009887;visual system development#GO:0150063;primary metabolic process#GO:0044238;cellular developmental process#GO:0048869;retinoid metabolic process#GO:0001523;neurogenesis#GO:0022008;diterpenoid metabolic process#GO:0016101;sensory organ development#GO:0007423;lipid metabolic process#GO:0006629;developmental process#GO:0032502;multicellular organismal process#GO:0032501;camera-type eye morphogenesis#GO:0048593;neuron development#GO:0048666;eye development#GO:0001654;animal gross anatomical part developmental process#GO:0160108;olefinic compound metabolic process#GO:0120254;generation of neurons#GO:0048699;sensory organ morphogenesis#GO:0090596;cell differentiation#GO:0030154;cell development#GO:0048468;anatomical structure morphogenesis#GO:0009653;animal organ development#GO:0048513;multicellular organism development#GO:0007275;anatomical structure formation involved in morphogenesis#GO:0048646;metabolic process#GO:0008152;neuron differentiation#GO:0030182;nervous system development#GO:0007399;retina development in camera-type eye#GO:0060041;sensory system development#GO:0048880;aldehyde metabolic process#GO:0006081;cellular process#GO:0009987 organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227 transferase#PC00220;glycosyltransferase#PC00111 HUMAN|HGNC=4138|UniProtKB=Q14697 Q14697 GANAB PTHR22762:SF162 ALPHA-GLUCOSIDASE NEUTRAL ALPHA-GLUCOSIDASE AB catalytic activity#GO:0003824;glucosidase activity#GO:0015926;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;alpha-glucosidase activity#GO:0090599;hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798 metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;protein N-linked glycosylation#GO:0006487;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;biosynthetic process#GO:0009058 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;endoplasmic reticulum protein-containing complex#GO:0140534;membrane-bounded organelle#GO:0043227 glucosidase#PC00108 HUMAN|HGNC=20152|UniProtKB=Q9C0A1 Q9C0A1 ZFHX2 PTHR45891:SF1 ZINC FINGER HOMEOBOX PROTEIN ZINC FINGER HOMEOBOX PROTEIN 2 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=6334|UniProtKB=P43631 P43631 KIR2DS2 PTHR11738:SF168 MHC CLASS I NK CELL RECEPTOR IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN-RELATED transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;immune receptor activity#GO:0140375 cellular process#GO:0009987;immune response-regulating signaling pathway#GO:0002764;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;cell surface receptor signaling pathway#GO:0007166;regulation of response to stimulus#GO:0048583;regulation of immune response#GO:0050776;cell communication#GO:0007154 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=12194|UniProtKB=A0A075B6N1 A0A075B6N1 TRBV19 PTHR23268:SF131 T-CELL RECEPTOR BETA CHAIN T CELL RECEPTOR BETA VARIABLE 19 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=27013|UniProtKB=Q86V40 Q86V40 TRABD2A PTHR31120:SF7 METALLOPROTEASE TIKI METALLOPROTEASE TIKI1 protease#PC00190;protein modifying enzyme#PC00260;metalloprotease#PC00153 HUMAN|HGNC=4627|UniProtKB=P09210 P09210 GSTA2 PTHR11571:SF262 GLUTATHIONE S-TRANSFERASE GLUTATHIONE S-TRANSFERASE A2 transferase activity#GO:0016740;catalytic activity#GO:0003824;glutathione transferase activity#GO:0004364;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;modified amino acid metabolic process#GO:0006575;sulfur compound metabolic process#GO:0006790;cellular response to xenobiotic stimulus#GO:0071466;xenobiotic metabolic process#GO:0006805;response to chemical#GO:0042221;response to stimulus#GO:0050896;response to xenobiotic stimulus#GO:0009410;cellular response to chemical stimulus#GO:0070887;metabolic process#GO:0008152;glutathione metabolic process#GO:0006749 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 transferase#PC00220 HUMAN|HGNC=18695|UniProtKB=O60284 O60284 ST18 PTHR10816:SF9 MYELIN TRANSCRIPTION FACTOR 1-RELATED SUPPRESSION OF TUMORIGENICITY 18 PROTEIN sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=26829|UniProtKB=Q8N8D7 Q8N8D7 NKAIN3 PTHR13084:SF2 T-CELL LYMPHOMA BREAKPOINT-ASSOCIATED TARGET 1-RELATED SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA-1-INTERACTING PROTEIN 3 regulation of biological process#GO:0050789;regulation of monoatomic ion transport#GO:0043269;regulation of metal ion transport#GO:0010959;biological regulation#GO:0065007;regulation of localization#GO:0032879;regulation of transport#GO:0051049 cellular anatomical structure#GO:0110165;membrane#GO:0016020 HUMAN|HGNC=18931|UniProtKB=Q3LI64 Q3LI64 KRTAP6-1 PTHR31678:SF2 KERATIN-ASSOCIATED PROTEIN 6-3 KERATIN-ASSOCIATED PROTEIN 6-1 structural protein#PC00211 HUMAN|HGNC=28757|UniProtKB=Q6UWV7 Q6UWV7 SHISAL2A PTHR31395:SF3 SHISA PROTEIN SHISA-LIKE-2A scaffold/adaptor protein#PC00226 HUMAN|HGNC=24711|UniProtKB=Q6ZSS7 Q6ZSS7 MFSD6 PTHR16172:SF43 MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6 immune system process#GO:0002376;antigen processing and presentation#GO:0019882 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=2170|UniProtKB=P26992 P26992 CNTFR PTHR23036:SF21 CYTOKINE RECEPTOR CILIARY NEUROTROPHIC FACTOR RECEPTOR SUBUNIT ALPHA binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888;protein binding#GO:0005515;molecular transducer activity#GO:0060089;cytokine receptor activity#GO:0004896;immune receptor activity#GO:0140375;signaling receptor activity#GO:0038023;cytokine binding#GO:0019955 cell surface receptor signaling pathway#GO:0007166;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;response to chemical#GO:0042221;response to cytokine#GO:0034097;cytokine-mediated signaling pathway#GO:0019221;response to peptide#GO:1901652;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;positive regulation of cell population proliferation#GO:0008284;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 extracellular protein-containing complex#GO:0140392;signaling receptor complex#GO:0043235;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane protein complex#GO:0098796;membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797 transmembrane signal receptor#PC00197 HUMAN|HGNC=25860|UniProtKB=Q8TAY7 Q8TAY7 FAM110D PTHR14758:SF3 AGAP005440-PA PROTEIN FAM110D HUMAN|HGNC=373|UniProtKB=O75969 O75969 AKAP3 PTHR10226:SF9 A KINASE ANCHOR PROTEIN A-KINASE ANCHOR PROTEIN 3 protein kinase A binding#GO:0051018;binding#GO:0005488;protein binding#GO:0005515 cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;cell surface receptor signaling pathway#GO:0007166;enzyme-linked receptor protein signaling pathway#GO:0007167;localization#GO:0051179;cell communication#GO:0007154;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cilium#GO:0005929;9+2 motile cilium#GO:0097729;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;cell projection#GO:0042995;sperm flagellum#GO:0036126;cellular anatomical structure#GO:0110165;organelle#GO:0043226;motile cilium#GO:0031514;sperm principal piece#GO:0097228 scaffold/adaptor protein#PC00226 HUMAN|HGNC=4014|UniProtKB=P21217 P21217 FUT3 PTHR11929:SF165 ALPHA- 1,3 -FUCOSYLTRANSFERASE 3-GALACTOSYL-N-ACETYLGLUCOSAMINIDE 4-ALPHA-L-FUCOSYLTRANSFERASE FUT3 alpha-(1->3)-fucosyltransferase activity#GO:0046920;glycosyltransferase activity#GO:0016757;hexosyltransferase activity#GO:0016758;fucosyltransferase activity#GO:0008417;transferase activity#GO:0016740;catalytic activity#GO:0003824 glycosyltransferase#PC00111 HUMAN|HGNC=30852|UniProtKB=Q16560 Q16560 SNRNP35 PTHR13952:SF31 U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KD U11_U12 SMALL NUCLEAR RIBONUCLEOPROTEIN 35 KDA PROTEIN snRNA binding#GO:0017069;RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729 RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;spliceosomal complex#GO:0005681;nucleus#GO:0005634;U12-type spliceosomal complex#GO:0005689;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;precatalytic spliceosome#GO:0071011;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229 RNA splicing factor#PC00148 HUMAN|HGNC=24797|UniProtKB=Q6ZRV2 Q6ZRV2 FAM83H PTHR16181:SF33 PROTEIN FAM83A-RELATED PROTEIN FAM83H kinase binding#GO:0019900;binding#GO:0005488;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;protein binding#GO:0005515 intermediate filament-based process#GO:0045103;cell communication#GO:0007154;localization#GO:0051179;regulation of cell motility#GO:2000145;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;positive regulation of cell motility#GO:2000147;cellular component organization#GO:0016043;protein localization to cytoskeleton#GO:0044380;signaling#GO:0023052;response to stimulus#GO:0050896;intermediate filament cytoskeleton organization#GO:0045104;protein localization to organelle#GO:0033365;regulation of cellular process#GO:0050794;regulation of cell migration#GO:0030334;intracellular protein localization#GO:0008104;positive regulation of locomotion#GO:0040017;cellular component organization or biogenesis#GO:0071840;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;positive regulation of cell migration#GO:0030335;macromolecule localization#GO:0033036;organelle organization#GO:0006996;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;regulation of locomotion#GO:0040012 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intermediate filament#GO:0005882;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;intracellular membraneless organelle#GO:0043232;supramolecular complex#GO:0099080;organelle#GO:0043226;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081 HUMAN|HGNC=4166|UniProtKB=O95995 O95995 DRC4 PTHR31543:SF3 DYNEIN REGULATORY COMPLEX SUBUNIT 4 DYNEIN REGULATORY COMPLEX SUBUNIT 4 positive regulation of cellular process#GO:0048522;positive regulation of response to stimulus#GO:0048584;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;plasma membrane bounded cell projection assembly#GO:0120031;flagellated sperm motility#GO:0030317;regulation of response to stimulus#GO:0048583;positive regulation of signal transduction#GO:0009967;cell motility#GO:0048870;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;microtubule-based movement#GO:0007018;reproductive process#GO:0022414;regulation of cell communication#GO:0010646;organelle assembly#GO:0070925;microtubule bundle formation#GO:0001578;microtubule cytoskeleton organization#GO:0000226;axoneme assembly#GO:0035082;cilium movement involved in cell motility#GO:0060294;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cell projection assembly#GO:0030031;positive regulation of biological process#GO:0048518;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;cellular component organization#GO:0016043;cilium assembly#GO:0060271;sperm motility#GO:0097722;regulation of biological process#GO:0050789;cell projection organization#GO:0030030;regulation of signaling#GO:0023051;cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;positive regulation of signaling#GO:0023056;cilium-dependent cell motility#GO:0060285;cilium organization#GO:0044782 plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;motile cilium#GO:0031514;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membrane-bounded organelle#GO:0043227;microtubule#GO:0005874;intracellular organelle#GO:0043229;cilium#GO:0005929;9+2 motile cilium#GO:0097729;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;sperm flagellum#GO:0036126;endomembrane system#GO:0012505;supramolecular complex#GO:0099080;microtubule cytoskeleton#GO:0015630;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;Golgi apparatus#GO:0005794 microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=21464|UniProtKB=Q86W26 Q86W26 NLRP10 PTHR45690:SF4 NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12 NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 10 regulation of response to external stimulus#GO:0032101;biological regulation#GO:0065007;regulation of response to stress#GO:0080134;regulation of biological process#GO:0050789;regulation of inflammatory response#GO:0050727;regulation of defense response#GO:0031347;regulation of response to stimulus#GO:0048583 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 defense/immunity protein#PC00090 HUMAN|HGNC=17060|UniProtKB=Q92845 Q92845 KIFAP3 PTHR15605:SF2 KINESIN-ASSOCIATED PROTEINS KINESIN-ASSOCIATED PROTEIN 3 plasma membrane bounded cell projection organization#GO:0120036;cell projection organization#GO:0030030;microtubule-based movement#GO:0007018;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;cilium organization#GO:0044782;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840 cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;axoneme#GO:0005930;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ciliary transition zone#GO:0035869;cilium#GO:0005929;intracellular organelle#GO:0043229;ciliary plasm#GO:0097014;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=13530|UniProtKB=Q9Y2B1 Q9Y2B1 RXYLT1 PTHR15576:SF1 RIBITOL-5-PHOSPHATE XYLOSYLTRANSFERASE 1 RIBITOL-5-PHOSPHATE XYLOSYLTRANSFERASE 1 xylosyltransferase activity#GO:0042285;glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194;transferase activity#GO:0016740;catalytic activity#GO:0003824;pentosyltransferase activity#GO:0016763;UDP-xylosyltransferase activity#GO:0035252 metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;protein O-linked glycosylation via mannose#GO:0035269;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;protein O-linked glycosylation#GO:0006493;cellular process#GO:0009987;biosynthetic process#GO:0009058 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 metabolite interconversion enzyme#PC00262;transferase#PC00220 HUMAN|HGNC=25641|UniProtKB=Q5VYX0 Q5VYX0 RNLS PTHR23357:SF1 RENALASE RENALASE catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on NAD(P)H#GO:0016651 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=16179|UniProtKB=P59827 P59827 BPIFB4 PTHR46019:SF4 BPI FOLD-CONTAINING FAMILY B MEMBER 4-RELATED BPI FOLD-CONTAINING FAMILY B MEMBER 4 HUMAN|HGNC=28947|UniProtKB=Q50LG9 Q50LG9 LRRC24 PTHR24373:SF269 SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN LEUCINE-RICH REPEAT-CONTAINING PROTEIN 24 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=16476|UniProtKB=Q9H0E2 Q9H0E2 TOLLIP PTHR16461:SF5 TOLL-INTERACTING PROTEIN TOLL-INTERACTING PROTEIN binding#GO:0005488;ubiquitin binding#GO:0043130;enzyme binding#GO:0019899;protein binding#GO:0005515 catabolic process#GO:0009056;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 Toll receptor signaling pathway#P00054>Tollip#P01379 HUMAN|HGNC=5101|UniProtKB=P31270 P31270 HOXA11 PTHR46092:SF3 HOMEOBOX PROTEIN HOX-A11-RELATED HOMEOBOX PROTEIN HOX-A11 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;skeletal system morphogenesis#GO:0048705;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;embryo development#GO:0009790;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;developmental process#GO:0032502;regulation of gene expression#GO:0010468;multicellular organism development#GO:0007275;embryonic morphogenesis#GO:0048598;regulation of biosynthetic process#GO:0009889;animal organ development#GO:0048513;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;animal organ morphogenesis#GO:0009887;regulation of cellular process#GO:0050794;embryo development ending in birth or egg hatching#GO:0009792;embryonic organ development#GO:0048568;chordate embryonic development#GO:0043009;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;skeletal system development#GO:0001501;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 homeodomain transcription factor#PC00119 HUMAN|HGNC=1389|UniProtKB=Q00975 Q00975 CACNA1B PTHR45628:SF6 VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1 VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;transporter activity#GO:0005215;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;monoatomic cation channel activity#GO:0005261;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;voltage-gated calcium channel activity#GO:0005245;channel activity#GO:0015267 transport#GO:0006810;import into cell#GO:0098657;establishment of localization#GO:0051234;calcium ion transmembrane import into cytosol#GO:0097553;calcium ion transport#GO:0006816;inorganic cation import across plasma membrane#GO:0098659;synaptic signaling#GO:0099536;cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;trans-synaptic signaling#GO:0099537;transmembrane transport#GO:0055085;cell communication#GO:0007154;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;chemical synaptic transmission#GO:0007268;calcium ion transmembrane transport#GO:0070588;calcium ion import#GO:0070509;regulation of biological process#GO:0050789;anterograde trans-synaptic signaling#GO:0098916;import across plasma membrane#GO:0098739;inorganic ion import across plasma membrane#GO:0099587;metal ion transport#GO:0030001;signaling#GO:0023052 cation channel complex#GO:0034703;transporter complex#GO:1990351;membrane#GO:0016020;cell periphery#GO:0071944;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;transmembrane transporter complex#GO:1902495;membrane protein complex#GO:0098796;voltage-gated calcium channel complex#GO:0005891;cell body#GO:0044297;calcium channel complex#GO:0034704;plasma membrane protein complex#GO:0098797;cellular anatomical structure#GO:0110165;neuronal cell body#GO:0043025 voltage-gated ion channel#PC00241 Ionotropic glutamate receptor pathway#P00037>Ca2+ channel#P01022;GABA-B receptor II signaling#P05731>Ca channel#P05753;Endogenous cannabinoid signaling#P05730>Ca2+ channel#P05750;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Ca2+channel#P00742;Metabotropic glutamate receptor group II pathway#P00040>Ca2+#P01051;Thyrotropin-releasing hormone receptor signaling pathway#P04394>Ca2+ channel#P04587;Metabotropic glutamate receptor group III pathway#P00039>Ca2+#P01041 HUMAN|HGNC=3810|UniProtKB=Q12947 Q12947 FOXF2 PTHR46262:SF3 FORKHEAD BOX PROTEIN BINIOU FORKHEAD BOX PROTEIN F2 nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;developmental process#GO:0032502;regulation of gene expression#GO:0010468;animal organ development#GO:0048513;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;animal organ morphogenesis#GO:0009887;regulation of cellular process#GO:0050794;animal gross anatomical part developmental process#GO:0160108;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=35412|UniProtKB=Q6ZMW3 Q6ZMW3 EML6 PTHR13720:SF52 WD-40 REPEAT PROTEIN ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 6 protein binding#GO:0005515;microtubule binding#GO:0008017;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631 microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=24796|UniProtKB=Q6NY19 Q6NY19 KANK3 PTHR24168:SF23 KN MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING KN MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 3 regulation of actin filament-based process#GO:0032970;negative regulation of cellular process#GO:0048523;regulation of anatomical structure size#GO:0090066;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;regulation of actin filament organization#GO:0110053;regulation of actin cytoskeleton organization#GO:0032956;regulation of actin polymerization or depolymerization#GO:0008064;biological regulation#GO:0065007;regulation of actin filament polymerization#GO:0030833;negative regulation of protein polymerization#GO:0032272;regulation of actin filament length#GO:0030832;regulation of biological quality#GO:0065008;negative regulation of protein-containing complex assembly#GO:0031333;negative regulation of cytoskeleton organization#GO:0051494;regulation of organelle organization#GO:0033043;regulation of supramolecular fiber organization#GO:1902903;regulation of biological process#GO:0050789;regulation of cellular component size#GO:0032535;cellular component organization#GO:0016043;negative regulation of organelle organization#GO:0010639;regulation of protein-containing complex assembly#GO:0043254;negative regulation of cellular component organization#GO:0051129;negative regulation of biological process#GO:0048519;regulation of cellular component biogenesis#GO:0044087;negative regulation of actin filament polymerization#GO:0030837;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;negative regulation of supramolecular fiber organization#GO:1902904;regulation of protein polymerization#GO:0032271 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 non-motor actin binding protein#PC00165 HUMAN|HGNC=29253|UniProtKB=Q9P2K1 Q9P2K1 CC2D2A PTHR20837:SF7 CENTROSOMAL PROTEIN-RELATED COILED-COIL AND C2 DOMAIN-CONTAINING PROTEIN 2A cilium organization#GO:0044782;non-motile cilium assembly#GO:1905515;localization#GO:0051179;organelle assembly#GO:0070925;protein localization to cilium#GO:0061512;cell projection organization#GO:0030030;protein localization to organelle#GO:0033365;cellular component organization#GO:0016043;cilium assembly#GO:0060271;intracellular protein localization#GO:0008104;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection assembly#GO:0120031;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cell projection assembly#GO:0030031;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;macromolecule localization#GO:0033036 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;ciliary transition zone#GO:0035869;cilium#GO:0005929 HUMAN|HGNC=2927|UniProtKB=Q14565 Q14565 DMC1 PTHR22942:SF30 RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER MEIOTIC RECOMBINATION PROTEIN DMC1 HOMOLOG catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;catalytic activity, acting on DNA#GO:0140097;nucleic acid binding#GO:0003676;binding#GO:0005488;ATP-dependent activity#GO:0140657;single-stranded DNA binding#GO:0003697;ATP-dependent activity, acting on DNA#GO:0008094;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690 nucleobase-containing compound metabolic process#GO:0006139;meiotic nuclear division#GO:0140013;macromolecule metabolic process#GO:0043170;chromosome organization#GO:0051276;DNA repair#GO:0006281;DNA damage response#GO:0006974;homologous recombination#GO:0035825;reproductive process#GO:0022414;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cell cycle#GO:0007049;cellular response to stimulus#GO:0051716;reciprocal homologous recombination#GO:0140527;organelle fission#GO:0048285;mitotic recombination#GO:0006312;recombinational repair#GO:0000725;meiosis I cell cycle process#GO:0061982;sexual reproduction#GO:0019953;cellular component assembly#GO:0022607;protein-DNA complex assembly#GO:0065004;response to stress#GO:0006950;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;protein-DNA complex organization#GO:0071824;cellular component organization or biogenesis#GO:0071840;double-strand break repair#GO:0006302;protein-containing complex organization#GO:0043933;DNA metabolic process#GO:0006259;chromosome organization involved in meiotic cell cycle#GO:0070192;meiotic cell cycle#GO:0051321;metabolic process#GO:0008152;DNA recombination#GO:0006310;response to stimulus#GO:0050896;meiosis I#GO:0007127;cellular component organization#GO:0016043;meiotic cell cycle process#GO:1903046;cell cycle process#GO:0022402;double-strand break repair via homologous recombination#GO:0000724;protein-containing complex assembly#GO:0065003;nuclear division#GO:0000280;reciprocal meiotic recombination#GO:0007131;cellular response to stress#GO:0033554 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;chromosome#GO:0005694;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;condensed chromosome#GO:0000793;membraneless organelle#GO:0043228;condensed nuclear chromosome#GO:0000794;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228 DNA metabolism protein#PC00009 HUMAN|HGNC=24671|UniProtKB=Q8NFF5 Q8NFF5 FLAD1 PTHR23293:SF9 FAD SYNTHETASE-RELATED FMN ADENYLYLTRANSFERASE BIFUNCTIONAL FAD DIPHOSPHATASE_FAD SYNTHASE nucleotidyltransferase activity#GO:0016779;catalytic activity#GO:0003824;transferase activity#GO:0016740;adenylyltransferase activity#GO:0070566;transferase activity, transferring phosphorus-containing groups#GO:0016772 phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;nucleotide metabolic process#GO:0009117;organophosphate biosynthetic process#GO:0090407;nucleotide biosynthetic process#GO:0009165;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing small molecule metabolic process#GO:0055086;flavin-containing compound metabolic process#GO:0042726 transferase#PC00220;metabolite interconversion enzyme#PC00262 Flavin biosynthesis#P02741>FAD synthetase#P02936 HUMAN|HGNC=26194|UniProtKB=Q6ZVK8 Q6ZVK8 NUDT18 PTHR22769:SF56 MUTT/NUDIX HYDROLASE 8-OXO-DGDP PHOSPHATASE NUDT18 hydrolase activity#GO:0016787;nucleoside diphosphate phosphatase activity#GO:0017110;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817 hydrolase#PC00121 HUMAN|HGNC=6509|UniProtKB=Q9NS86 Q9NS86 LANCL2 PTHR12736:SF11 LANC-LIKE PROTEIN LANC-LIKE PROTEIN 2 regulation of biological process#GO:0050789;regulation of cell communication#GO:0010646;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cellular response to alcohol#GO:1905957;regulation of cellular process#GO:0050794;regulation of abscisic acid-activated signaling pathway#GO:0009787;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;regulation of response to alcohol#GO:1901419 nucleus#GO:0005634;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=3282|UniProtKB=P60842 P60842 EIF4A1 PTHR24031:SF221 RNA HELICASE EUKARYOTIC INITIATION FACTOR 4A-I cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;cytoplasmic translation#GO:0002181;translational initiation#GO:0006413;translation#GO:0006412;metabolic process#GO:0008152;cytoplasmic translational initiation#GO:0002183;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 nucleus#GO:0005634;protein-containing complex#GO:0032991;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228;intracellular protein-containing complex#GO:0140535;cytoplasmic stress granule#GO:0010494;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 RNA metabolism protein#PC00031;RNA helicase#PC00032 HUMAN|HGNC=46|UniProtKB=Q2M3G0 Q2M3G0 ABCB5 PTHR24221:SF217 ATP-BINDING CASSETTE SUB-FAMILY B ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 5 primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;cell periphery#GO:0071944;apical part of cell#GO:0045177;membrane#GO:0016020;apical plasma membrane#GO:0016324 ATP-binding cassette (ABC) transporter#PC00003 HUMAN|HGNC=22048|UniProtKB=P60323 P60323 NANOS3 PTHR12887:SF12 NANOS PROTEIN NANOS HOMOLOG 3 binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723 regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;developmental process involved in reproduction#GO:0003006;germ cell development#GO:0007281;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of protein metabolic process#GO:0051248;reproductive process#GO:0022414;sexual reproduction#GO:0019953;anatomical structure development#GO:0048856;multicellular organismal reproductive process#GO:0048609;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of protein metabolic process#GO:0051246;cellular process#GO:0009987;oogenesis#GO:0048477;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;cell differentiation#GO:0030154;gamete generation#GO:0007276;negative regulation of metabolic process#GO:0009892;cell development#GO:0048468;cellular process involved in reproduction in multicellular organism#GO:0022412;negative regulation of translation#GO:0017148 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;perinuclear region of cytoplasm#GO:0048471;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031 HUMAN|HGNC=21532|UniProtKB=Q92543 Q92543 SNX19 PTHR22775:SF31 SORTING NEXIN SORTING NEXIN-19 ion binding#GO:0043167;phosphatidylinositol binding#GO:0035091;small molecule binding#GO:0036094;binding#GO:0005488;anion binding#GO:0043168 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=29011|UniProtKB=O15050 O15050 TRANK1 PTHR21529:SF4 MAMMARY TURMOR VIRUS RECEPTOR HOMOLOG 1, 2 MTVR1, 2 TPR AND ANKYRIN REPEAT-CONTAINING PROTEIN 1 HUMAN|HGNC=8777|UniProtKB=O00408 O00408 PDE2A PTHR11347:SF102 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 3',5'-CYCLIC PHOSPHODIESTERASE PDE-2-RELATED protein binding#GO:0005515;hydrolase activity#GO:0016787;binding#GO:0005488;identical protein binding#GO:0042802;cyclic-nucleotide phosphodiesterase activity#GO:0004112;phosphoric ester hydrolase activity#GO:0042578;phosphoric diester hydrolase activity#GO:0008081;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;ribonucleotide metabolic process#GO:0009259;negative regulation of cell communication#GO:0010648;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;nucleotide metabolic process#GO:0009117;negative regulation of intracellular signal transduction#GO:1902532;regulation of biological process#GO:0050789;purine nucleotide metabolic process#GO:0006163;regulation of organelle organization#GO:0033043;purine-containing compound metabolic process#GO:0072521;negative regulation of biological process#GO:0048519;phosphorus metabolic process#GO:0006793;regulation of cellular component organization#GO:0051128;small molecule metabolic process#GO:0044281;cyclic purine nucleotide metabolic process#GO:0052652;metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing small molecule metabolic process#GO:0055086;purine-containing compound catabolic process#GO:0072523;positive regulation of biological process#GO:0048518;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;negative regulation of signal transduction#GO:0009968;positive regulation of macromolecule metabolic process#GO:0010604;purine nucleotide catabolic process#GO:0006195;organophosphate catabolic process#GO:0046434;positive regulation of biosynthetic process#GO:0009891;regulation of mitochondrion organization#GO:0010821;purine ribonucleotide catabolic process#GO:0009154;primary metabolic process#GO:0044238;regulation of cell communication#GO:0010646;nucleoside phosphate metabolic process#GO:0006753;carbohydrate derivative catabolic process#GO:1901136;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;nucleoside phosphate catabolic process#GO:1901292;regulation of cellular process#GO:0050794;cyclic nucleotide metabolic process#GO:0009187;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;nucleotide catabolic process#GO:0009166;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;ribonucleotide catabolic process#GO:0009261;positive regulation of cellular process#GO:0048522;carbohydrate derivative metabolic process#GO:1901135;cGMP metabolic process#GO:0046068;nucleobase-containing compound catabolic process#GO:0034655;organophosphate metabolic process#GO:0019637;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;nucleobase-containing compound metabolic process#GO:0006139;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of response to stimulus#GO:0048585 cytoplasm#GO:0005737;perinuclear region of cytoplasm#GO:0048471;organelle inner membrane#GO:0019866;bounding membrane of organelle#GO:0098588;cell junction#GO:0030054;synaptic membrane#GO:0097060;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;organelle lumen#GO:0043233;mitochondrial matrix#GO:0005759;outer membrane#GO:0019867;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;plasma membrane#GO:0005886;organelle outer membrane#GO:0031968;plasma membrane region#GO:0098590;nucleus#GO:0005634;mitochondrial envelope#GO:0005740;cell periphery#GO:0071944;mitochondrial membrane#GO:0031966;membrane-enclosed lumen#GO:0031974;membrane#GO:0016020;cytosol#GO:0005829;mitochondrial inner membrane#GO:0005743;organelle membrane#GO:0031090;mitochondrial outer membrane#GO:0005741;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 hydrolase#PC00121;phosphodiesterase#PC00185 HUMAN|HGNC=21604|UniProtKB=Q9Y6I3 Q9Y6I3 EPN1 PTHR12276:SF48 EPSIN/ENT-RELATED EPSIN-1 lipid binding#GO:0008289;protein binding#GO:0005515;clathrin binding#GO:0030276;phospholipid binding#GO:0005543;binding#GO:0005488 receptor-mediated endocytosis#GO:0006898;import into cell#GO:0098657;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810;vesicle-mediated transport#GO:0016192;endocytosis#GO:0006897;clathrin-dependent endocytosis#GO:0072583;cellular process#GO:0009987 vesicle#GO:0031982;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;coated vesicle membrane#GO:0030662;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;clathrin coat#GO:0030118;intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;coated vesicle#GO:0030135;cytoplasmic vesicle#GO:0031410;coated membrane#GO:0048475;membrane coat#GO:0030117;cell periphery#GO:0071944;vesicle membrane#GO:0012506;membrane#GO:0016020;vesicle coat#GO:0030120;plasma membrane#GO:0005886;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;clathrin vesicle coat#GO:0030125;clathrin-coated vesicle#GO:0030136;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;clathrin-coated vesicle membrane#GO:0030665 membrane traffic protein#PC00150;membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=18598|UniProtKB=Q96CW5 Q96CW5 TUBGCP3 PTHR19302:SF14 GAMMA TUBULIN COMPLEX PROTEIN GAMMA-TUBULIN COMPLEX COMPONENT 3 cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;microtubule binding#GO:0008017;binding#GO:0005488;protein binding#GO:0005515 cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;spindle assembly#GO:0051225;microtubule polymerization or depolymerization#GO:0031109;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;spindle organization#GO:0007051;microtubule-based process#GO:0007017;protein-containing complex organization#GO:0043933;microtubule polymerization#GO:0046785;meiotic cell cycle#GO:0051321;chromosome segregation#GO:0007059;cytoplasmic microtubule organization#GO:0031122;mitotic cell cycle#GO:0000278;reproductive process#GO:0022414;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;cell cycle#GO:0007049;microtubule nucleation#GO:0007020;cell cycle process#GO:0022402;protein polymerization#GO:0051258;protein-containing complex assembly#GO:0065003;microtubule cytoskeleton organization#GO:0000226;supramolecular fiber organization#GO:0097435;organelle assembly#GO:0070925;sexual reproduction#GO:0019953 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;intracellular organelle#GO:0043229 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HUMAN|HGNC=29509|UniProtKB=Q96BI3 Q96BI3 APH1A PTHR12889:SF3 GAMMA-SECRETASE SUBUNIT APH-1 GAMMA-SECRETASE SUBUNIT APH-1A protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;cell communication#GO:0007154;protein metabolic process#GO:0019538;proteolysis#GO:0006508;biosynthetic process#GO:0009058;biological regulation#GO:0065007;gene expression#GO:0010467;protein maturation#GO:0051604;signal transduction#GO:0007165;cellular process#GO:0009987;protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;Notch signaling pathway#GO:0007219;cell surface receptor signaling pathway#GO:0007166;metabolic process#GO:0008152 membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;catalytic complex#GO:1902494 protease#PC00190;protein modifying enzyme#PC00260 Alzheimer disease-amyloid secretase pathway#P00003>Aph-1#P00091;Notch signaling pathway#P00045>Aph-1#P01109;Alzheimer disease-presenilin pathway#P00004>Aph-1#P00170 HUMAN|HGNC=2697|UniProtKB=Q10586 Q10586 DBP PTHR11988:SF7 THYROTROPH EMBRYONIC FACTOR RELATED D SITE-BINDING PROTEIN RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of DNA-templated transcription#GO:0006355;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 basic leucine zipper transcription factor#PC00056;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=13302|UniProtKB=Q9BZJ6 Q9BZJ6 GPR63 PTHR24245:SF1 G-PROTEIN COUPLED RECEPTOR G PROTEIN-COUPLED RECEPTOR 63-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=10518|UniProtKB=Q8N1B4 Q8N1B4 VPS52 PTHR14190:SF16 SUPPRESSOR OF ACTIN MUTATIONS 2/VACUOLAR PROTEIN SORTING 52 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 52 HOMOLOG binding#GO:0005488;SNARE binding#GO:0000149;syntaxin binding#GO:0019905;protein binding#GO:0005515 localization within membrane#GO:0051668;lysosomal transport#GO:0007041;localization#GO:0051179;cellular localization#GO:0051641;cytosolic transport#GO:0016482;endocytic recycling#GO:0032456;vacuolar transport#GO:0007034;transport#GO:0006810;intracellular transport#GO:0046907;endosomal transport#GO:0016197;vesicle-mediated transport to the plasma membrane#GO:0098876;establishment of localization#GO:0051234;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;retrograde transport, endosome to Golgi#GO:0042147;vesicle-mediated transport#GO:0016192 endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;vesicle tethering complex#GO:0099023;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 membrane traffic protein#PC00150 HUMAN|HGNC=29392|UniProtKB=Q96JF6 Q96JF6 ZNF594 PTHR24376:SF249 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 594-RELATED regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HUMAN|HGNC=52681|UniProtKB=A0A5F9ZHS7 A0A5F9ZHS7 NFILZ PTHR15284:SF7 NUCLEAR FACTOR INTERLEUKIN-3-REGULATED PROTEIN NFIL3 LIKE PROTEIN circadian rhythm#GO:0007623;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;rhythmic process#GO:0048511;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 gene-specific transcriptional regulator#PC00264;basic leucine zipper transcription factor#PC00056 HUMAN|HGNC=8363|UniProtKB=O14581 O14581 OR7A17 PTHR48001:SF142 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 7A17 transmembrane signal receptor#PC00197 HUMAN|HGNC=2603|UniProtKB=O43174 O43174 CYP26A1 PTHR24286:SF101 CYTOCHROME P450 26 CYTOCHROME P450 26A1 catalytic activity#GO:0003824;monooxygenase activity#GO:0004497;oxidoreductase activity#GO:0016491 cellular process#GO:0009987;lipid catabolic process#GO:0016042;carboxylic acid catabolic process#GO:0046395;nervous system development#GO:0007399;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;monocarboxylic acid catabolic process#GO:0072329;hormone metabolic process#GO:0042445;lipid metabolic process#GO:0006629;developmental process#GO:0032502;metabolic process#GO:0008152;diterpenoid metabolic process#GO:0016101;multicellular organism development#GO:0007275;retinoid metabolic process#GO:0001523;regulation of hormone levels#GO:0010817;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;small molecule catabolic process#GO:0044282;central nervous system development#GO:0007417;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;terpenoid metabolic process#GO:0006721;animal gross anatomical part developmental process#GO:0160108;oxoacid metabolic process#GO:0043436;regulation of biological quality#GO:0065008;system development#GO:0048731;isoprenoid metabolic process#GO:0006720;anatomical structure development#GO:0048856 oxygenase#PC00177 HUMAN|HGNC=7758|UniProtKB=Q99519 Q99519 NEU1 PTHR10628:SF25 SIALIDASE SIALIDASE-1 hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798 carbohydrate catabolic process#GO:0016052;ceramide metabolic process#GO:0006672;sphingolipid catabolic process#GO:0030149;primary metabolic process#GO:0044238;oligosaccharide catabolic process#GO:0009313;catabolic process#GO:0009056;liposaccharide metabolic process#GO:1903509;glycolipid metabolic process#GO:0006664;carbohydrate metabolic process#GO:0005975;carbohydrate derivative catabolic process#GO:1901136;metabolic process#GO:0008152;sphingolipid metabolic process#GO:0006665;lipid metabolic process#GO:0006629;oligosaccharide metabolic process#GO:0009311;lipid catabolic process#GO:0016042;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987 membrane#GO:0016020;lysosome#GO:0005764;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;vacuole#GO:0005773;intracellular organelle#GO:0043229;lytic vacuole#GO:0000323;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 hydrolase#PC00121 HUMAN|HGNC=23640|UniProtKB=Q6U7Q0 Q6U7Q0 ZNF322 PTHR23226:SF325 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER PROTEIN 322 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=3255|UniProtKB=Q9NZJ5 Q9NZJ5 EIF2AK3 PTHR11042:SF166 EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 3 protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 regulation of translational initiation#GO:0006446;negative regulation of translation#GO:0017148;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of translation#GO:0006417;regulation of macromolecule biosynthetic process#GO:0010556;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 Gonadotropin-releasing hormone receptor pathway#P06664>EIF2AK3#P06813 HUMAN|HGNC=2672|UniProtKB=P51397 P51397 DAP PTHR13177:SF3 DEATH-ASSOCIATED PROTEIN 1 DEATH-ASSOCIATED PROTEIN 1 binding#GO:0005488;ribonucleoprotein complex binding#GO:0043021;ribosome binding#GO:0043022;protein-containing complex binding#GO:0044877 negative regulation of translation#GO:0017148;response to stimulus#GO:0050896;negative regulation of metabolic process#GO:0009892;signaling#GO:0023052;negative regulation of gene expression#GO:0010629;regulation of autophagy#GO:0010506;negative regulation of biological process#GO:0048519;apoptotic process#GO:0006915;regulation of biological process#GO:0050789;regulation of protein metabolic process#GO:0051246;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;signal transduction#GO:0007165;cell communication#GO:0007154;negative regulation of catabolic process#GO:0009895;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of protein metabolic process#GO:0051248;programmed cell death#GO:0012501;cell death#GO:0008219;cellular response to stimulus#GO:0051716;regulation of biosynthetic process#GO:0009889;apoptotic signaling pathway#GO:0097190;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;negative regulation of autophagy#GO:0010507;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;negative regulation of macromolecule metabolic process#GO:0010605 HUMAN|HGNC=26707|UniProtKB=Q6A162 Q6A162 KRT40 PTHR23239:SF90 INTERMEDIATE FILAMENT KERATIN, TYPE I CYTOSKELETAL 40 structural molecule activity#GO:0005198 intermediate filament cytoskeleton organization#GO:0045104;cell differentiation#GO:0030154;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;tissue morphogenesis#GO:0048729;anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;intermediate filament-based process#GO:0045103;animal gross anatomical part developmental process#GO:0160108;intermediate filament organization#GO:0045109;epithelium development#GO:0060429;epithelial cell differentiation#GO:0030855;tissue development#GO:0009888;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;morphogenesis of an epithelium#GO:0002009;developmental process#GO:0032502 organelle#GO:0043226;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;intermediate filament#GO:0005882;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622 intermediate filament#PC00129 HUMAN|HGNC=19962|UniProtKB=Q6ZNE5 Q6ZNE5 ATG14 PTHR13664:SF0 BECLIN 1-ASSOCIATED AUTOPHAGY-RELATED KEY REGULATOR BECLIN 1-ASSOCIATED AUTOPHAGY-RELATED KEY REGULATOR protein-membrane adaptor activity#GO:0043495;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 cellular component assembly#GO:0022607;macroautophagy#GO:0016236;response to nutrient levels#GO:0031667;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;response to stress#GO:0006950;autophagy#GO:0006914;cellular process#GO:0009987;autophagosome organization#GO:1905037;mitophagy#GO:0000423;cellular component organization or biogenesis#GO:0071840;autophagosome assembly#GO:0000045;protein-containing complex organization#GO:0043933;metabolic process#GO:0008152;cellular response to starvation#GO:0009267;autophagosome maturation#GO:0097352;autophagy of mitochondrion#GO:0000422;cellular response to nutrient levels#GO:0031669;response to stimulus#GO:0050896;catabolic process#GO:0009056;protein-containing complex disassembly#GO:0032984;response to starvation#GO:0042594;cellular component organization#GO:0016043;cellular response to stimulus#GO:0051716;localization#GO:0051179;cellular component disassembly#GO:0022411;vacuole organization#GO:0007033;process utilizing autophagic mechanism#GO:0061919;organelle assembly#GO:0070925;organelle localization#GO:0051640;cellular response to stress#GO:0033554 membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;phosphatidylinositol 3-kinase complex, class III#GO:0035032;transferase complex, transferring phosphorus-containing groups#GO:0061695;autophagosome#GO:0005776;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;vacuole#GO:0005773;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;phagophore assembly site#GO:0000407;transferase complex#GO:1990234;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;extrinsic component of membrane#GO:0019898 HUMAN|HGNC=9940|UniProtKB=Q92781 Q92781 RDH5 PTHR43313:SF12 SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C RETINOL DEHYDROGENASE 5 all-trans-retinol dehydrogenase (NAD+) activity#GO:0004745;oxidoreductase activity#GO:0016491;alcohol dehydrogenase (NAD+) activity#GO:0004022;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;catalytic activity#GO:0003824;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 metabolic process#GO:0008152;lipid metabolic process#GO:0006629;terpenoid metabolic process#GO:0006721;isoprenoid metabolic process#GO:0006720;retinoid metabolic process#GO:0001523;diterpenoid metabolic process#GO:0016101;primary metabolic process#GO:0044238;cellular process#GO:0009987 organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;endoplasmic reticulum lumen#GO:0005788;membrane#GO:0016020;membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;endomembrane system#GO:0012505;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090 metabolite interconversion enzyme#PC00262;dehydrogenase#PC00092 HUMAN|HGNC=6071|UniProtKB=P49441 P49441 INPP1 PTHR43028:SF3 3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1 INOSITOL POLYPHOSPHATE 1-PHOSPHATASE hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;regulation of biological process#GO:0050789;cellular process#GO:0009987;synaptic signaling#GO:0099536;chemical synaptic transmission#GO:0007268;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;signaling#GO:0023052;anterograde trans-synaptic signaling#GO:0098916 phosphatase#PC00181;hydrolase#PC00121 HUMAN|HGNC=12999|UniProtKB=O43345 O43345 ZNF208 PTHR24376:SF154 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 208-RELATED gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HUMAN|HGNC=30076|UniProtKB=Q9BUI4 Q9BUI4 POLR3C PTHR12949:SF0 RNA POLYMERASE III DNA DIRECTED -RELATED DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;transferase complex, transferring phosphorus-containing groups#GO:0061695;RNA polymerase III complex#GO:0005666;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;protein-containing complex#GO:0032991;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535 DNA-directed RNA polymerase#PC00019 HUMAN|HGNC=24178|UniProtKB=Q8WU03 Q8WU03 GLYATL2 PTHR15298:SF20 L-COA N-ACYLTRANSFERASE-RELATED GLYCINE N-ACYLTRANSFERASE-LIKE PROTEIN 2 acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746 mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 acyltransferase#PC00042 HUMAN|HGNC=16090|UniProtKB=O00264 O00264 PGRMC1 PTHR10281:SF23 MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT 1 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 transmembrane signal receptor#PC00197 HUMAN|HGNC=2949|UniProtKB=Q8TD57 Q8TD57 DNAH3 PTHR10676:SF405 DYNEIN HEAVY CHAIN FAMILY PROTEIN DYNEIN AXONEMAL HEAVY CHAIN 3 macromolecular conformation isomerase activity#GO:0120543;catalytic activity#GO:0003824;isomerase activity#GO:0016853;cytoskeletal motor activity#GO:0003774;ATP-dependent activity#GO:0140657;polypeptide conformation or assembly isomerase activity#GO:0120544;binding#GO:0005488;microtubule motor activity#GO:0003777;protein binding#GO:0005515 motile cilium assembly#GO:0044458;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;protein-containing complex organization#GO:0043933;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cilium movement involved in cell motility#GO:0060294;cell projection assembly#GO:0030031;cellular process#GO:0009987;sperm flagellum assembly#GO:0120316;cilium-dependent cell motility#GO:0060285;cilium organization#GO:0044782;spermatid differentiation#GO:0048515;cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;inner dynein arm assembly#GO:0036159;cell differentiation#GO:0030154;cell projection organization#GO:0030030;gamete generation#GO:0007276;cell development#GO:0048468;cellular process involved in reproduction in multicellular organism#GO:0022412;cilium assembly#GO:0060271;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;sperm motility#GO:0097722;cellular developmental process#GO:0048869;flagellated sperm motility#GO:0030317;plasma membrane bounded cell projection assembly#GO:0120031;developmental process#GO:0032502;spermatogenesis#GO:0007283;male gamete generation#GO:0048232;plasma membrane bounded cell projection organization#GO:0120036;microtubule cytoskeleton organization#GO:0000226;anatomical structure development#GO:0048856;axoneme assembly#GO:0035082;multicellular organismal reproductive process#GO:0048609;organelle assembly#GO:0070925;sexual reproduction#GO:0019953;microtubule bundle formation#GO:0001578;spermatid development#GO:0007286;axonemal dynein complex assembly#GO:0070286;cell motility#GO:0048870;microtubule-based movement#GO:0007018;reproductive process#GO:0022414;developmental process involved in reproduction#GO:0003006;germ cell development#GO:0007281 axonemal dynein complex#GO:0005858;dynein complex#GO:0030286;cellular anatomical structure#GO:0110165;motile cilium#GO:0031514;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;9+2 motile cilium#GO:0097729;intracellular organelle#GO:0043229;cilium#GO:0005929;catalytic complex#GO:1902494;axoneme#GO:0005930;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;microtubule cytoskeleton#GO:0015630;ciliary plasm#GO:0097014;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;inner dynein arm#GO:0036156;membraneless organelle#GO:0043228 microtubule or microtubule-binding cytoskeletal protein#PC00157;microtubule binding motor protein#PC00156 Huntington disease#P00029>Dynein complex#P00774 HUMAN|HGNC=17761|UniProtKB=Q9NZC2 Q9NZC2 TREM2 PTHR11860:SF54 POLYMERIC-IMMUNOGLOBULIN RECEPTOR TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cell communication#GO:0007154;regulation of immune response#GO:0050776;positive regulation of calcium-mediated signaling#GO:0050850;regulation of inflammatory response#GO:0050727;regulation of defense response#GO:0031347;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of immune system process#GO:0002682;regulation of calcium-mediated signaling#GO:0050848;regulation of response to biotic stimulus#GO:0002831;positive regulation of ERK1 and ERK2 cascade#GO:0070374;regulation of cell communication#GO:0010646;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;regulation of innate immune response#GO:0045088;regulation of plasma membrane bounded cell projection organization#GO:0120035;positive regulation of MAPK cascade#GO:0043410;regulation of cell projection organization#GO:0031344;regulation of response to stress#GO:0080134;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of defense response#GO:0031349;regulation of response to stimulus#GO:0048583;positive regulation of response to stimulus#GO:0048584;positive regulation of endocytosis#GO:0045807;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of cell activation#GO:0050867;positive regulation of cellular process#GO:0048522;positive regulation of signaling#GO:0023056;regulation of intracellular signal transduction#GO:1902531;positive regulation of cellular component organization#GO:0051130;regulation of signaling#GO:0023051;response to stimulus#GO:0050896;regulation of cellular component organization#GO:0051128;signaling#GO:0023052;regulation of leukocyte activation#GO:0002694;regulation of biological process#GO:0050789;regulation of cell activation#GO:0050865;positive regulation of multicellular organismal process#GO:0051240;positive regulation of response to external stimulus#GO:0032103;regulation of transport#GO:0051049;regulation of localization#GO:0032879;positive regulation of inflammatory response#GO:0050729;regulation of MAPK cascade#GO:0043408;regulation of endocytosis#GO:0030100;positive regulation of leukocyte activation#GO:0002696;regulation of ERK1 and ERK2 cascade#GO:0070372;regulation of response to external stimulus#GO:0032101;regulation of multicellular organismal process#GO:0051239;positive regulation of immune system process#GO:0002684;positive regulation of transport#GO:0051050;positive regulation of biological process#GO:0048518;regulation of macrophage activation#GO:0043030;signal transduction#GO:0007165;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=17947|UniProtKB=Q5T1C6 Q5T1C6 THEM4 PTHR12418:SF19 ACYL-COENZYME A THIOESTERASE THEM4 ACYL-COENZYME A THIOESTERASE THEM4 hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;thiolester hydrolase activity#GO:0016790;catalytic activity#GO:0003824;fatty acyl-CoA hydrolase activity#GO:0047617;acyl-CoA hydrolase activity#GO:0016289;deacylase activity#GO:0160215 small molecule metabolic process#GO:0044281;apoptotic process#GO:0006915;cell death#GO:0008219;monocarboxylic acid metabolic process#GO:0032787;cellular component organization#GO:0016043;programmed cell death#GO:0012501;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;regulation of biological quality#GO:0065008;oxoacid metabolic process#GO:0043436;biological regulation#GO:0065007;regulation of mitochondrial membrane permeability#GO:0046902;mitochondrion organization#GO:0007005;apoptotic mitochondrial changes#GO:0008637;regulation of membrane permeability#GO:0090559;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization or biogenesis#GO:0071840;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631 mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 esterase#PC00097;hydrolase#PC00121;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=555|UniProtKB=O43747 O43747 AP1G1 PTHR22780:SF26 ADAPTIN, ALPHA/GAMMA/EPSILON AP-1 COMPLEX SUBUNIT GAMMA-1 cargo adaptor activity#GO:0140312;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 vesicle-mediated transport#GO:0016192;cytosolic transport#GO:0016482;establishment of localization in cell#GO:0051649;Golgi to endosome transport#GO:0006895;cellular process#GO:0009987;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;post-Golgi vesicle-mediated transport#GO:0006892;intracellular transport#GO:0046907;transport#GO:0006810;Golgi vesicle transport#GO:0048193 membrane#GO:0016020;vesicle membrane#GO:0012506;endomembrane system#GO:0012505;transport vesicle membrane#GO:0030658;transport vesicle#GO:0030133;clathrin-coated vesicle#GO:0030136;Golgi apparatus#GO:0005794;Golgi-associated vesicle#GO:0005798;trans-Golgi network transport vesicle membrane#GO:0012510;organelle membrane#GO:0031090;vesicle#GO:0031982;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;AP-1 adaptor complex#GO:0030121;trans-Golgi network transport vesicle#GO:0030140;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane coat#GO:0030117;cytoplasm#GO:0005737;vesicle coat#GO:0030120;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;clathrin vesicle coat#GO:0030125;bounding membrane of organelle#GO:0098588;AP-type membrane coat adaptor complex#GO:0030119;clathrin-coated vesicle membrane#GO:0030665;intracellular vesicle#GO:0097708;coated vesicle membrane#GO:0030662;Golgi-associated vesicle membrane#GO:0030660;clathrin coat#GO:0030118;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;coated vesicle#GO:0030135;coated membrane#GO:0048475 membrane traffic protein#PC00150 HUMAN|HGNC=22204|UniProtKB=Q96HN2 Q96HN2 AHCYL2 PTHR23420:SF2 ADENOSYLHOMOCYSTEINASE S-ADENOSYLHOMOCYSTEINE HYDROLASE-LIKE PROTEIN 2 hydrolase activity#GO:0016787;catalytic activity#GO:0003824 metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;sulfur compound metabolic process#GO:0006790;cellular process#GO:0009987;homocysteine metabolic process#GO:0050667;carbohydrate derivative metabolic process#GO:1901135;proteinogenic amino acid metabolic process#GO:0170039;amino acid metabolic process#GO:0006520;nucleobase-containing compound metabolic process#GO:0006139;oxoacid metabolic process#GO:0043436;purine nucleoside metabolic process#GO:0042278;modified amino acid metabolic process#GO:0006575;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;purine-containing compound metabolic process#GO:0072521;nucleoside metabolic process#GO:0009116;small molecule metabolic process#GO:0044281 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 hydrolase#PC00121;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=2689|UniProtKB=P09172 P09172 DBH PTHR10157:SF29 DOPAMINE BETA HYDROXYLASE RELATED DOPAMINE BETA-HYDROXYLASE oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;monooxygenase activity#GO:0004497;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705 phenol-containing compound biosynthetic process#GO:0046189;amine metabolic process#GO:0009308;phenol-containing compound metabolic process#GO:0018958;cellular process#GO:0009987;response to alcohol#GO:0097305;response to stimulus#GO:0050896;response to chemical#GO:0042221;catabolic process#GO:0009056;multicellular organismal process#GO:0032501;biogenic amine metabolic process#GO:0006576;biosynthetic process#GO:0009058;metabolic process#GO:0008152;amine catabolic process#GO:0009310;response to oxygen-containing compound#GO:1901700;catecholamine metabolic process#GO:0006584 organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;secretory vesicle#GO:0099503;membrane#GO:0016020;vesicle membrane#GO:0012506;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;extracellular region#GO:0005576;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular vesicle#GO:0097708;secretory granule membrane#GO:0030667 hydroxylase#PC00122 Dopamine receptor mediated signaling pathway#P05912>DBH#P05955;Adrenaline and noradrenaline biosynthesis#P00001>DBH#P00063 HUMAN|HGNC=15375|UniProtKB=Q8N0Y3 Q8N0Y3 OR4N4 PTHR48002:SF4 OLFACTORY RECEPTOR OLFACTORY RECEPTOR-RELATED transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=12110|UniProtKB=A0A0A6YYC5 A0A0A6YYC5 TRAV14DV4 PTHR23267:SF486 IMMUNOGLOBULIN LIGHT CHAIN T CELL RECEPTOR ALPHA VARIABLE 14_DELTA VARIABLE 4 response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 protein-containing complex#GO:0032991 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=30723|UniProtKB=Q6P9F0 Q6P9F0 CCDC62 PTHR34491:SF134 A-TYPE INCLUSION PROTEIN, PUTATIVE-RELATED COILED-COIL DOMAIN-CONTAINING PROTEIN 62 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HUMAN|HGNC=21328|UniProtKB=Q8WWR8 Q8WWR8 NEU4 PTHR10628:SF22 SIALIDASE SIALIDASE-4 catalytic activity#GO:0003824;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787 ceramide metabolic process#GO:0006672;carbohydrate catabolic process#GO:0016052;sphingolipid catabolic process#GO:0030149;primary metabolic process#GO:0044238;carbohydrate derivative catabolic process#GO:1901136;carbohydrate metabolic process#GO:0005975;glycolipid metabolic process#GO:0006664;catabolic process#GO:0009056;oligosaccharide catabolic process#GO:0009313;liposaccharide metabolic process#GO:1903509;lipid metabolic process#GO:0006629;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;oligosaccharide metabolic process#GO:0009311;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;lipid catabolic process#GO:0016042 lysosome#GO:0005764;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;vacuole#GO:0005773;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;lytic vacuole#GO:0000323 hydrolase#PC00121 HUMAN|HGNC=29469|UniProtKB=Q5TA79 Q5TA79 LCE2A PTHR48615:SF7 LATE CORNIFIED ENVELOPE PROTEIN 1C LATE CORNIFIED ENVELOPE PROTEIN 2A-RELATED HUMAN|HGNC=30225|UniProtKB=Q9NWF4 Q9NWF4 SLC52A1 PTHR12929:SF20 SOLUTE CARRIER FAMILY 52 SOLUTE CARRIER FAMILY 52, RIBOFLAVIN TRANSPORTER, MEMBER 1 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 vitamin transport#GO:0051180;establishment of localization#GO:0051234;localization#GO:0051179;nitrogen compound transport#GO:0071705;transport#GO:0006810 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 secondary carrier transporter#PC00258 HUMAN|HGNC=21490|UniProtKB=A0PJW8 A0PJW8 DAPL1 PTHR13177:SF2 DEATH-ASSOCIATED PROTEIN 1 DEATH-ASSOCIATED PROTEIN-LIKE 1 binding#GO:0005488;ribonucleoprotein complex binding#GO:0043021;ribosome binding#GO:0043022;protein-containing complex binding#GO:0044877 negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of protein metabolic process#GO:0051246;signal transduction#GO:0007165;cellular process#GO:0009987;negative regulation of translation#GO:0017148;regulation of autophagy#GO:0010506;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;apoptotic process#GO:0006915;response to stimulus#GO:0050896;negative regulation of metabolic process#GO:0009892;signaling#GO:0023052;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;apoptotic signaling pathway#GO:0097190;regulation of biosynthetic process#GO:0009889;negative regulation of autophagy#GO:0010507;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;cell communication#GO:0007154;negative regulation of catabolic process#GO:0009895;programmed cell death#GO:0012501;cell death#GO:0008219;cellular response to stimulus#GO:0051716;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of protein metabolic process#GO:0051248 HUMAN|HGNC=1151|UniProtKB=O43684 O43684 BUB3 PTHR10971:SF31 MRNA EXPORT FACTOR AND BUB3 MITOTIC CHECKPOINT PROTEIN BUB3 protein binding#GO:0005515;ubiquitin binding#GO:0043130;binding#GO:0005488 negative regulation of cell cycle#GO:0045786;negative regulation of metaphase/anaphase transition of cell cycle#GO:1902100;negative regulation of mitotic sister chromatid segregation#GO:0033048;regulation of chromosome segregation#GO:0051983;negative regulation of chromosome segregation#GO:0051985;regulation of cell cycle process#GO:0010564;cell cycle checkpoint signaling#GO:0000075;regulation of chromosome separation#GO:1905818;negative regulation of mitotic cell cycle phase transition#GO:1901991;signal transduction#GO:0007165;mitotic spindle assembly checkpoint signaling#GO:0007094;cellular process#GO:0009987;negative regulation of sister chromatid segregation#GO:0033046;negative regulation of mitotic cell cycle#GO:0045930;regulation of mitotic cell cycle phase transition#GO:1901990;negative regulation of mitotic sister chromatid separation#GO:2000816;signaling#GO:0023052;regulation of cell cycle#GO:0051726;regulation of sister chromatid segregation#GO:0033045;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;negative regulation of mitotic nuclear division#GO:0045839;cell cycle process#GO:0022402;regulation of organelle organization#GO:0033043;negative regulation of biological process#GO:0048519;negative regulation of cell cycle phase transition#GO:1901988;regulation of mitotic nuclear division#GO:0007088;mitotic cell cycle process#GO:1903047;negative regulation of chromosome separation#GO:1905819;regulation of mitotic sister chromatid separation#GO:0010965;negative regulation of cell cycle process#GO:0010948;regulation of chromosome organization#GO:0033044;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;regulation of nuclear division#GO:0051783;negative regulation of nuclear division#GO:0051784;regulation of mitotic metaphase/anaphase transition#GO:0030071;regulation of mitotic cell cycle#GO:0007346;regulation of mitotic sister chromatid segregation#GO:0033047;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;negative regulation of chromosome organization#GO:2001251;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;mitotic cell cycle#GO:0000278;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;negative regulation of mitotic metaphase/anaphase transition#GO:0045841;cell cycle#GO:0007049;mitotic cell cycle checkpoint signaling#GO:0007093;regulation of cell cycle phase transition#GO:1901987;negative regulation of organelle organization#GO:0010639;negative regulation of cellular component organization#GO:0051129 intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;organelle lumen#GO:0043233;kinetochore#GO:0000776;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;chromosome, centromeric region#GO:0000775;condensed chromosome#GO:0000793;protein-containing complex#GO:0032991;supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232;condensed chromosome, centromeric region#GO:0000779;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 RNA metabolism protein#PC00031 HUMAN|HGNC=7114|UniProtKB=Q13064 Q13064 MKRN3 PTHR11224:SF38 MAKORIN-RELATED E3 UBIQUITIN-PROTEIN LIGASE MAKORIN-3 ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740 post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;primary metabolic process#GO:0044238;protein modification process#GO:0036211;cellular process#GO:0009987;protein modification by small protein conjugation#GO:0032446;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=29083|UniProtKB=O75121 O75121 MFAP3L PTHR14340:SF2 MICROFIBRIL-ASSOCIATED GLYCOPROTEIN 3 MICROFIBRILLAR-ASSOCIATED PROTEIN 3-LIKE HUMAN|HGNC=2948|UniProtKB=Q9P225 Q9P225 DNAH2 PTHR10676:SF183 DYNEIN HEAVY CHAIN FAMILY PROTEIN DYNEIN AXONEMAL HEAVY CHAIN 2 macromolecular conformation isomerase activity#GO:0120543;catalytic activity#GO:0003824;isomerase activity#GO:0016853;cytoskeletal motor activity#GO:0003774;ATP-dependent activity#GO:0140657;binding#GO:0005488;polypeptide conformation or assembly isomerase activity#GO:0120544;microtubule motor activity#GO:0003777;protein binding#GO:0005515 cellular process#GO:0009987;cilium movement involved in cell motility#GO:0060294;microtubule-based movement#GO:0007018;cell motility#GO:0048870;cilium or flagellum-dependent cell motility#GO:0001539;cilium movement#GO:0003341;microtubule-based process#GO:0007017;cilium-dependent cell motility#GO:0060285 microtubule cytoskeleton#GO:0015630;microtubule associated complex#GO:0005875;ciliary plasm#GO:0097014;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;dynein complex#GO:0030286;cellular anatomical structure#GO:0110165;motile cilium#GO:0031514;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;9+2 motile cilium#GO:0097729;cilium#GO:0005929;axoneme#GO:0005930;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 microtubule or microtubule-binding cytoskeletal protein#PC00157;microtubule binding motor protein#PC00156 HUMAN|HGNC=8785|UniProtKB=P16499 P16499 PDE6A PTHR11347:SF115 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE ROD CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT ALPHA hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;cyclic-nucleotide phosphodiesterase activity#GO:0004112;phosphoric ester hydrolase activity#GO:0042578;phosphoric diester hydrolase activity#GO:0008081;hydrolase activity#GO:0016787 negative regulation of cell communication#GO:0010648;eye development#GO:0001654;system development#GO:0048731;anatomical structure development#GO:0048856;negative regulation of intracellular signal transduction#GO:1902532;regulation of signaling#GO:0023051;animal gross anatomical part developmental process#GO:0160108;regulation of intracellular signal transduction#GO:1902531;camera-type eye development#GO:0043010;negative regulation of signaling#GO:0023057;regulation of cell communication#GO:0010646;visual system development#GO:0150063;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;animal organ development#GO:0048513;multicellular organism development#GO:0007275;regulation of response to stimulus#GO:0048583;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;sensory organ development#GO:0007423;negative regulation of signal transduction#GO:0009968;retina development in camera-type eye#GO:0060041;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of response to stimulus#GO:0048585;multicellular organismal process#GO:0032501;sensory system development#GO:0048880 membrane#GO:0016020;9+0 non-motile cilium#GO:0097731;photoreceptor cell cilium#GO:0097733;cell periphery#GO:0071944;neuron projection#GO:0043005;plasma membrane region#GO:0098590;ciliary membrane#GO:0060170;plasma membrane#GO:0005886;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;cellular anatomical structure#GO:0110165;organelle#GO:0043226;photoreceptor outer segment#GO:0001750;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cilium#GO:0005929;cell projection membrane#GO:0031253;non-motile cilium#GO:0097730;membrane-bounded organelle#GO:0043227 phosphodiesterase#PC00185;hydrolase#PC00121 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>PDEalphabeta#P00759 HUMAN|HGNC=2990|UniProtKB=Q99704 Q99704 DOK1 PTHR21258:SF46 DOCKING PROTEIN RELATED DOCKING PROTEIN 1 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;Ras protein signal transduction#GO:0007265;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;intracellular signaling cassette#GO:0141124;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 scaffold/adaptor protein#PC00226 Angiogenesis#P00005>Dok-R#P00180 HUMAN|HGNC=28862|UniProtKB=Q6KC79 Q6KC79 NIPBL PTHR21704:SF19 NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED NIPPED-B-LIKE PROTEIN chromatin binding#GO:0003682;binding#GO:0005488 nucleobase-containing compound metabolic process#GO:0006139;tube development#GO:0035295;brain development#GO:0007420;mitotic sister chromatid cohesion#GO:0007064;multicellular organismal process#GO:0032501;replication-born double-strand break repair via sister chromatid exchange#GO:1990414;skeletal system morphogenesis#GO:0048705;mitotic cell cycle process#GO:1903047;chromosome organization#GO:0051276;macromolecule metabolic process#GO:0043170;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;DNA damage response#GO:0006974;developmental process#GO:0032502;DNA repair#GO:0006281;mitotic cell cycle#GO:0000278;animal organ morphogenesis#GO:0009887;heart morphogenesis#GO:0003007;cellular response to stimulus#GO:0051716;cell cycle#GO:0007049;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;system development#GO:0048731;localization#GO:0051179;sister chromatid cohesion#GO:0007062;anatomical structure development#GO:0048856;embryonic organ development#GO:0048568;embryo development ending in birth or egg hatching#GO:0009792;recombinational repair#GO:0000725;embryo development#GO:0009790;nervous system development#GO:0007399;head development#GO:0060322;heart development#GO:0007507;establishment of protein localization#GO:0045184;cellular process#GO:0009987;organelle organization#GO:0006996;response to stress#GO:0006950;double-strand break repair#GO:0006302;embryonic morphogenesis#GO:0048598;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;animal organ development#GO:0048513;DNA recombination#GO:0006310;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;response to stimulus#GO:0050896;central nervous system development#GO:0007417;circulatory system development#GO:0072359;anatomical structure morphogenesis#GO:0009653;cell cycle process#GO:0022402;double-strand break repair via homologous recombination#GO:0000724;cellular component organization#GO:0016043;skeletal system development#GO:0001501;cellular response to stress#GO:0033554;chordate embryonic development#GO:0043009;animal gross anatomical part developmental process#GO:0160108 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=20086|UniProtKB=Q6P158 Q6P158 DHX57 PTHR18934:SF145 ATP-DEPENDENT RNA HELICASE ATP-DEPENDENT RNA HELICASE DHX57-RELATED isomerase activity#GO:0016853;helicase activity#GO:0004386;macromolecular conformation isomerase activity#GO:0120543;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;RNA binding#GO:0003723;ATP-dependent activity#GO:0140657;nucleic acid binding#GO:0003676;binding#GO:0005488 RNA helicase#PC00032;RNA metabolism protein#PC00031 HUMAN|HGNC=4204|UniProtKB=Q8N0V5 Q8N0V5 GCNT2 PTHR19297:SF190 GLYCOSYLTRANSFERASE 14 FAMILY MEMBER N-ACETYLLACTOSAMINIDE BETA-1,6-N-ACETYLGLUCOSAMINYL-TRANSFERASE glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194;acetylglucosaminyltransferase activity#GO:0008375;catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758 transforming growth factor beta receptor signaling pathway#GO:0007179;cellular process#GO:0009987;signal transduction#GO:0007165;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;biological regulation#GO:0065007;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;cell surface receptor signaling pathway#GO:0007166;response to endogenous stimulus#GO:0009719;cellular response to transforming growth factor beta stimulus#GO:0071560;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to growth factor#GO:0070848;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;signaling#GO:0023052;response to transforming growth factor beta#GO:0071559;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cellular response to growth factor stimulus#GO:0071363 glycosyltransferase#PC00111 HUMAN|HGNC=4291|UniProtKB=Q14410 Q14410 GK2 PTHR10196:SF46 SUGAR KINASE GLYCEROL KINASE 2 phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740 organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;biosynthetic process#GO:0009058;alcohol metabolic process#GO:0006066;acylglycerol metabolic process#GO:0006639;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;triglyceride metabolic process#GO:0006641;carbohydrate derivative biosynthetic process#GO:1901137;neutral lipid metabolic process#GO:0006638;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;glycerolipid metabolic process#GO:0046486;small molecule metabolic process#GO:0044281;carbohydrate metabolic process#GO:0005975;organophosphate biosynthetic process#GO:0090407 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 kinase#PC00137;carbohydrate kinase#PC00065 HUMAN|HGNC=6251|UniProtKB=Q12809 Q12809 KCNH2 PTHR10217:SF506 VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL VOLTAGE-GATED INWARDLY RECTIFYING POTASSIUM CHANNEL KCNH2 channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;potassium channel activity#GO:0005267;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation channel activity#GO:0005261;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated monoatomic ion channel activity#GO:0005244;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215 regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;localization#GO:0051179;transport#GO:0006810;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 ion channel#PC00133;transporter#PC00227 HUMAN|HGNC=15432|UniProtKB=Q96R08 Q96R08 OR5B12 PTHR48018:SF51 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5B12 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 nervous system process#GO:0050877;sensory perception#GO:0007600;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signaling#GO:0023052;sensory perception of smell#GO:0007608;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;cellular process#GO:0009987;signal transduction#GO:0007165;biological regulation#GO:0065007;multicellular organismal process#GO:0032501 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=7734|UniProtKB=P07197 P07197 NEFM PTHR45652:SF3 GLIAL FIBRILLARY ACIDIC PROTEIN NEUROFILAMENT MEDIUM POLYPEPTIDE structural constituent of cytoskeleton#GO:0005200;structural molecule activity#GO:0005198 cellular component organization or biogenesis#GO:0071840;supramolecular fiber organization#GO:0097435;intermediate filament bundle assembly#GO:0045110;intermediate filament-based process#GO:0045103;intermediate filament organization#GO:0045109;cellular component assembly#GO:0022607;intermediate filament cytoskeleton organization#GO:0045104;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987 supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;neuron projection#GO:0043005;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;cell junction#GO:0030054;intermediate filament#GO:0005882;cytoskeleton#GO:0005856;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;postsynapse#GO:0098794;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;axon#GO:0030424;intracellular organelle#GO:0043229 cytoskeletal protein#PC00085;intermediate filament#PC00129 HUMAN|HGNC=24802|UniProtKB=Q68CQ1 Q68CQ1 MROH7 PTHR23120:SF17 MAESTRO-RELATED HEAT DOMAIN-CONTAINING MAESTRO HEAT-LIKE REPEAT-CONTAINING PROTEIN FAMILY MEMBER 7 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=27071|UniProtKB=A0A087X179 A0A087X179 TBC1D3E PTHR22957:SF571 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN TBC1 DOMAIN FAMILY MEMBER 3-RELATED molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;enzyme activator activity#GO:0008047 protein-binding activity modulator#PC00095;G-protein modulator#PC00022;GTPase-activating protein#PC00257 HUMAN|HGNC=13450|UniProtKB=Q8N9N5 Q8N9N5 BANP PTHR16243:SF2 BTG3-ASSOCIATED NUCLEAR PROTEIN BANP PROTEIN BANP HUMAN|HGNC=18934|UniProtKB=Q8IUC3 Q8IUC3 KRTAP7-1 PTHR38504:SF1 KERATIN-ASSOCIATED PROTEIN 7-1 KERATIN-ASSOCIATED PROTEIN 7-1 structural protein#PC00211 HUMAN|HGNC=4040|UniProtKB=Q14332 Q14332 FZD2 PTHR11309:SF34 FRIZZLED FRIZZLED-2 binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888;Wnt-protein binding#GO:0017147;protein binding#GO:0005515;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;canonical Wnt signaling pathway#GO:0060070;non-canonical Wnt signaling pathway#GO:0035567;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;Wnt signaling pathway#GO:0016055;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 Angiogenesis#P00005>Fzd#P00189;Cadherin signaling pathway#P00012>Frizzled#P00475;Wnt signaling pathway#P00057>Frizzled#P01428;Alzheimer disease-presenilin pathway#P00004>Frizzled#P00119 HUMAN|HGNC=28695|UniProtKB=Q8N1A0 Q8N1A0 KRT222 PTHR47082:SF1 KERATIN-LIKE PROTEIN KRT222 KERATIN-LIKE PROTEIN KRT222 structural protein#PC00211 HUMAN|HGNC=29108|UniProtKB=Q68CR1 Q68CR1 SEL1L3 PTHR44444:SF1 PROTEIN SEL-1 HOMOLOG 3 PROTEIN SEL-1 HOMOLOG 3 HUMAN|HGNC=17661|UniProtKB=Q53H76 Q53H76 PLA1A PTHR11610:SF111 LIPASE PHOSPHOLIPASE A1 MEMBER A catalytic activity#GO:0003824;lipase activity#GO:0016298;glycerophospholipase activity#GO:0004620;carboxylic ester hydrolase activity#GO:0052689;phospholipase activity#GO:0120569;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787 catabolic process#GO:0009056;primary metabolic process#GO:0044238;metabolic process#GO:0008152;cellular process#GO:0009987;lipid metabolic process#GO:0006629;lipid catabolic process#GO:0016042 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 metabolite interconversion enzyme#PC00262;lipase#PC00143;hydrolase#PC00121 2-arachidonoylglycerol biosynthesis#P05726>PLA1#P05735 HUMAN|HGNC=16910|UniProtKB=Q9Y646 Q9Y646 CPQ PTHR12053:SF6 PROTEASE FAMILY M28 PLASMA GLUTAMATE CARBOXYPEPTIDASE-RELATED CARBOXYPEPTIDASE Q catalytic activity#GO:0003824;metalloexopeptidase activity#GO:0008235;metallopeptidase activity#GO:0008237;hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;peptide metabolic process#GO:0006518;regulation of biological quality#GO:0065008;proteolysis#GO:0006508;metabolic process#GO:0008152;catabolic process#GO:0009056;hormone metabolic process#GO:0042445;biological regulation#GO:0065007;modified amino acid metabolic process#GO:0006575;primary metabolic process#GO:0044238;phenol-containing compound metabolic process#GO:0018958;peptide catabolic process#GO:0043171;regulation of hormone levels#GO:0010817;cellular process#GO:0009987 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease#PC00190;protein modifying enzyme#PC00260;metalloprotease#PC00153 HUMAN|HGNC=15504|UniProtKB=Q9BX70 Q9BX70 BTBD2 PTHR45774:SF6 BTB/POZ DOMAIN-CONTAINING BTB_POZ DOMAIN-CONTAINING PROTEIN 2 system development#GO:0048731;neurogenesis#GO:0022008;multicellular organism development#GO:0007275;anatomical structure development#GO:0048856;cellular developmental process#GO:0048869;developmental process#GO:0032502;animal gross anatomical part developmental process#GO:0160108;nervous system development#GO:0007399;cell differentiation#GO:0030154;multicellular organismal process#GO:0032501;cellular process#GO:0009987 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=10850|UniProtKB=P34896 P34896 SHMT1 PTHR11680:SF59 SERINE HYDROXYMETHYLTRANSFERASE SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC small molecule binding#GO:0036094;binding#GO:0005488;anion binding#GO:0043168;ion binding#GO:0043167;heterocyclic compound binding#GO:1901363;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring one-carbon groups#GO:0016741 cellular process#GO:0009987;proteinogenic amino acid metabolic process#GO:0170039;amino acid metabolic process#GO:0006520;biosynthetic process#GO:0009058;amino acid biosynthetic process#GO:0008652;metabolic process#GO:0008152;small molecule biosynthetic process#GO:0044283;proteinogenic amino acid biosynthetic process#GO:0170038;primary metabolic process#GO:0044238;modified amino acid metabolic process#GO:0006575;carboxylic acid metabolic process#GO:0019752;carboxylic acid biosynthetic process#GO:0046394;folic acid-containing compound metabolic process#GO:0006760;pteridine-containing compound metabolic process#GO:0042558;small molecule metabolic process#GO:0044281;oxoacid metabolic process#GO:0043436;tetrahydrofolate metabolic process#GO:0046653 nucleus#GO:0005634;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 methyltransferase#PC00155;metabolite interconversion enzyme#PC00262 Serine glycine biosynthesis#P02776>Glycine hydroxymethyltransferase#P03158 HUMAN|HGNC=20085|UniProtKB=Q8NHQ9 Q8NHQ9 DDX55 PTHR24031:SF2 RNA HELICASE ATP-DEPENDENT RNA HELICASE DDX55 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;nucleic acid biosynthetic process#GO:0141187;ribosomal large subunit biogenesis#GO:0042273;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;maturation of LSU-rRNA#GO:0000470;metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974 RNA metabolism protein#PC00031;RNA helicase#PC00032 HUMAN|HGNC=23807|UniProtKB=Q9NXG2 Q9NXG2 THUMPD1 PTHR13452:SF15 THUMP DOMAIN CONTAINING PROTEIN 1-RELATED THUMP DOMAIN-CONTAINING PROTEIN 1 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;protein-RNA adaptor activity#GO:0140517 metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;tRNA modification#GO:0006400 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=8609|UniProtKB=O95453 O95453 PARN PTHR15092:SF44 POLY A -SPECIFIC RIBONUCLEASE/TARGET OF EGR1, MEMBER 1 POLY(A)-SPECIFIC RIBONUCLEASE PARN hydrolase activity#GO:0016787;RNA binding#GO:0003723;nuclease activity#GO:0004518;exonuclease activity#GO:0004527;nucleic acid binding#GO:0003676;binding#GO:0005488;3'-5'-RNA exonuclease activity#GO:0000175;RNA nuclease activity#GO:0004540;3'-5' exonuclease activity#GO:0008408;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;positive regulation of mRNA catabolic process#GO:0061014;nuclear-transcribed mRNA poly(A) tail shortening#GO:0000289;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;RNA biosynthetic process#GO:0032774;positive regulation of RNA metabolic process#GO:0051254;regulation of RNA stability#GO:0043487;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;macromolecule biosynthetic process#GO:0009059;nucleic acid catabolic process#GO:0141188;regulation of nucleobase-containing compound metabolic process#GO:0019219;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;biosynthetic process#GO:0009058;negative regulation of biosynthetic process#GO:0009890;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;regulatory ncRNA-mediated gene silencing#GO:0031047;macromolecule metabolic process#GO:0043170;regulatory ncRNA processing#GO:0070918;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;positive regulation of catabolic process#GO:0009896;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;regulation of mRNA stability#GO:0043488;RNA catabolic process#GO:0006401;nucleic acid biosynthetic process#GO:0141187;positive regulation of metabolic process#GO:0009893;RNA metabolic process#GO:0016070;regulation of biological quality#GO:0065008;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;RNA destabilization#GO:0050779;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;gene expression#GO:0010467;RNA processing#GO:0006396;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;positive regulation of mRNA metabolic process#GO:1903313;mRNA destabilization#GO:0061157;macromolecule catabolic process#GO:0009057;RNA 3'-end processing#GO:0031123;regulation of mRNA metabolic process#GO:1903311 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 mRNA polyadenylation factor#PC00146 HUMAN|HGNC=21895|UniProtKB=Q9H7X7 Q9H7X7 IFT22 PTHR24073:SF528 DRAB5-RELATED INTRAFLAGELLAR TRANSPORT PROTEIN 22 HOMOLOG hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817 intracellular transport#GO:0046907;transport#GO:0006810;intracellular protein transport#GO:0006886;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;protein transport#GO:0015031;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 small GTPase#PC00208;G-protein#PC00020 HUMAN|HGNC=13486|UniProtKB=A6NNY8 A6NNY8 USP27X PTHR21646:SF30 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 27 hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity, acting on a protein#GO:0140096;cysteine-type deubiquitinase activity#GO:0004843;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of protein stability#GO:0031647;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of biological quality#GO:0065008;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355 cysteine protease#PC00081 HUMAN|HGNC=20573|UniProtKB=Q96QZ0 Q96QZ0 PANX3 PTHR15759:SF3 PANNEXIN PANNEXIN-3 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;channel activity#GO:0015267;wide pore channel activity#GO:0022829 transport#GO:0006810;monoatomic ion transport#GO:0006811;cell communication#GO:0007154;localization#GO:0051179;monoatomic cation transport#GO:0006812;establishment of localization#GO:0051234;regulation of biological process#GO:0050789;cellular process#GO:0009987;signaling#GO:0023052;cell-cell signaling#GO:0007267;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HUMAN|HGNC=18017|UniProtKB=Q12769 Q12769 NUP160 PTHR21286:SF0 NUCLEAR PORE COMPLEX PROTEIN NUP160 NUCLEAR PORE COMPLEX PROTEIN NUP160 structural molecule activity#GO:0005198;structural constituent of nuclear pore#GO:0017056 mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;protein import into nucleus#GO:0006606;protein transport#GO:0015031;ribosome biogenesis#GO:0042254;telomere tethering at nuclear periphery#GO:0034398;cellular response to stress#GO:0033554;establishment of organelle localization#GO:0051656;response to stimulus#GO:0050896;ribonucleoprotein complex biogenesis#GO:0022613;response to abiotic stimulus#GO:0009628;cellular component organization#GO:0016043;ribosomal large subunit export from nucleus#GO:0000055;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;intracellular protein transport#GO:0006886;gene expression#GO:0010467;response to chemical#GO:0042221;chromosome localization#GO:0050000;response to temperature stimulus#GO:0009266;protein export from nucleus#GO:0006611;response to stress#GO:0006950;response to heat#GO:0009408;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular response to heat#GO:0034605;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;nucleic acid transport#GO:0050657;localization#GO:0051179;nuclear export#GO:0051168;nuclear transport#GO:0051169;response to nitrogen compound#GO:1901698;organelle localization#GO:0051640;nucleocytoplasmic transport#GO:0006913;ribosome localization#GO:0033750;RNA transport#GO:0050658;transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery#GO:0000972;protein localization to organelle#GO:0033365;RNA localization#GO:0006403;nucleobase-containing compound transport#GO:0015931;establishment of RNA localization#GO:0051236;mRNA transport#GO:0051028;telomere localization#GO:0034397;cellular response to stimulus#GO:0051716;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;poly(A)+ mRNA export from nucleus#GO:0016973;macromolecule metabolic process#GO:0043170;chromosome organization#GO:0051276;intracellular protein localization#GO:0008104;ribosomal subunit export from nucleus#GO:0000054;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;transport#GO:0006810;biosynthetic process#GO:0009058;protein localization to nucleus#GO:0034504;nitrogen compound transport#GO:0071705;macromolecule localization#GO:0033036;import into nucleus#GO:0051170;macromolecule biosynthetic process#GO:0009059;post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery#GO:0000973 nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;nucleus#GO:0005634;organelle envelope#GO:0031967;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear pore#GO:0005643;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229 transporter#PC00227 HUMAN|HGNC=417|UniProtKB=P05062 P05062 ALDOB PTHR11627:SF2 FRUCTOSE-BISPHOSPHATE ALDOLASE FRUCTOSE-BISPHOSPHATE ALDOLASE B aldehyde-lyase activity#GO:0016832;fructose-bisphosphate aldolase activity#GO:0004332;lyase activity#GO:0016829;carbon-carbon lyase activity#GO:0016830;catalytic activity#GO:0003824 monocarboxylic acid metabolic process#GO:0032787;phosphorus metabolic process#GO:0006793;carboxylic acid metabolic process#GO:0019752;purine nucleotide metabolic process#GO:0006163;ribonucleoside diphosphate metabolic process#GO:0009185;purine-containing compound metabolic process#GO:0072521;pyridine-containing compound catabolic process#GO:0072526;small molecule metabolic process#GO:0044281;pyruvate metabolic process#GO:0006090;pyridine nucleotide catabolic process#GO:0019364;oxoacid metabolic process#GO:0043436;ribonucleotide metabolic process#GO:0009259;purine nucleoside diphosphate metabolic process#GO:0009135;carbohydrate catabolic process#GO:0016052;nucleotide metabolic process#GO:0009117;nicotinamide nucleotide metabolic process#GO:0046496;ATP metabolic process#GO:0046034;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;ADP catabolic process#GO:0046032;purine-containing compound catabolic process#GO:0072523;nucleobase-containing small molecule metabolic process#GO:0055086;purine nucleoside diphosphate catabolic process#GO:0009137;primary metabolic process#GO:0044238;purine ribonucleotide catabolic process#GO:0009154;purine nucleoside triphosphate metabolic process#GO:0009144;nucleoside diphosphate catabolic process#GO:0009134;catabolic process#GO:0009056;nucleoside phosphate catabolic process#GO:1901292;carbohydrate metabolic process#GO:0005975;nucleoside phosphate metabolic process#GO:0006753;carbohydrate derivative catabolic process#GO:1901136;nucleoside triphosphate metabolic process#GO:0009141;nucleoside diphosphate metabolic process#GO:0009132;pyridine-containing compound metabolic process#GO:0072524;purine nucleotide catabolic process#GO:0006195;organophosphate catabolic process#GO:0046434;ribonucleoside diphosphate catabolic process#GO:0009191;cellular respiration#GO:0045333;purine ribonucleoside diphosphate catabolic process#GO:0009181;aerobic respiration#GO:0009060;organophosphate metabolic process#GO:0019637;nucleobase-containing compound catabolic process#GO:0034655;carbohydrate derivative metabolic process#GO:1901135;ribonucleotide catabolic process#GO:0009261;glycolytic process#GO:0006096;purine ribonucleoside triphosphate metabolic process#GO:0009205;nucleobase-containing compound metabolic process#GO:0006139;nucleotide catabolic process#GO:0009166;generation of precursor metabolites and energy#GO:0006091;purine ribonucleoside diphosphate metabolic process#GO:0009179;ADP metabolic process#GO:0046031;energy derivation by oxidation of organic compounds#GO:0015980 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 aldolase#PC00044;lyase#PC00144 Glycolysis#P00024>Aldolase#P00679;Fructose galactose metabolism#P02744>Fructose bisphosphate aldolase#P02959 HUMAN|HGNC=5213|UniProtKB=P51659 P51659 HSD17B4 PTHR13078:SF56 PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2-RELATED PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2 oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824 fatty acid beta-oxidation#GO:0006635;lipid metabolic process#GO:0006629;fatty acid oxidation#GO:0019395;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;lipid modification#GO:0030258;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;lipid catabolic process#GO:0016042;monocarboxylic acid catabolic process#GO:0072329;oxoacid metabolic process#GO:0043436;fatty acid catabolic process#GO:0009062;lipid oxidation#GO:0034440;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;small molecule catabolic process#GO:0044282;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;peroxisome#GO:0005777;microbody#GO:0042579 HUMAN|HGNC=2195|UniProtKB=P39060 P39060 COL18A1 PTHR24023:SF1034 COLLAGEN ALPHA COLLAGEN ALPHA-1(XVIII) CHAIN-RELATED extracellular matrix structural constituent#GO:0005201;structural molecule activity#GO:0005198 vasculature development#GO:0001944;anatomical structure formation involved in morphogenesis#GO:0048646;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;endothelial cell differentiation#GO:0045446;developmental process#GO:0032502;tube development#GO:0035295;multicellular organismal process#GO:0032501;tissue development#GO:0009888;epithelial cell differentiation#GO:0030855;epithelium development#GO:0060429;cellular process#GO:0009987;external encapsulating structure organization#GO:0045229;system development#GO:0048731;extracellular matrix organization#GO:0030198;angiogenesis#GO:0001525;anatomical structure development#GO:0048856;skeletal system development#GO:0001501;extracellular structure organization#GO:0043062;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;cell morphogenesis#GO:0000902;circulatory system development#GO:0072359;cell differentiation#GO:0030154;blood vessel development#GO:0001568;tube morphogenesis#GO:0035239;anatomical structure morphogenesis#GO:0009653;blood vessel morphogenesis#GO:0048514;cellular component organization#GO:0016043 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 Integrin signalling pathway#P00034>Collagen#P00922 HUMAN|HGNC=12499|UniProtKB=Q14139 Q14139 UBE4A PTHR13931:SF16 UBIQUITINATION FACTOR E4 UBIQUITIN CONJUGATION FACTOR E4 A acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 modification-dependent protein catabolic process#GO:0019941;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;catabolic process#GO:0009056;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;response to endoplasmic reticulum stress#GO:0034976;ERAD pathway#GO:0036503;protein metabolic process#GO:0019538;cellular process#GO:0009987;response to stress#GO:0006950;proteasomal protein catabolic process#GO:0010498;response to chemical#GO:0042221;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=19575|UniProtKB=A6ND48 A6ND48 OR14I1 PTHR26452:SF933 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 14I1-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 sensory perception of chemical stimulus#GO:0007606;sensory perception#GO:0007600;nervous system process#GO:0050877;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;system process#GO:0003008 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=13276|UniProtKB=O14681 O14681 EI24 PTHR21389:SF0 P53 INDUCED PROTEIN ETOPOSIDE-INDUCED PROTEIN 2.4 HOMOLOG cellular process#GO:0009987;autophagy#GO:0006914;metabolic process#GO:0008152;macroautophagy#GO:0016236;process utilizing autophagic mechanism#GO:0061919;catabolic process#GO:0009056 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 HUMAN|HGNC=18969|UniProtKB=Q8NI17 Q8NI17 IL31RA PTHR23036:SF96 CYTOKINE RECEPTOR INTERLEUKIN-31 RECEPTOR SUBUNIT ALPHA transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488;protein binding#GO:0005515;molecular transducer activity#GO:0060089;cytokine receptor activity#GO:0004896;signaling receptor activity#GO:0038023;cytokine binding#GO:0019955;immune receptor activity#GO:0140375 cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;positive regulation of cell population proliferation#GO:0008284;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cytokine-mediated signaling pathway#GO:0019221;response to peptide#GO:1901652;regulation of cell population proliferation#GO:0042127;cell communication#GO:0007154;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165;biological regulation#GO:0065007;response to chemical#GO:0042221;response to cytokine#GO:0034097;cell surface receptor signaling pathway#GO:0007166 cell periphery#GO:0071944;signaling receptor complex#GO:0043235;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 transmembrane signal receptor#PC00197 HUMAN|HGNC=31249|UniProtKB=Q5JQS5 Q5JQS5 OR2B11 PTHR26453:SF112 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2B11 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 response to stimulus#GO:0050896;response to chemical#GO:0042221;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;detection of chemical stimulus#GO:0009593;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;system process#GO:0003008;sensory perception#GO:0007600;nervous system process#GO:0050877;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=15795|UniProtKB=Q9NQ39 Q9NQ39 RPS10P5 PTHR12146:SF8 40S RIBOSOMAL PROTEIN S10 RIBOSOMAL PROTEIN ES10-LIKE-RELATED structural molecule activity#GO:0005198;RNA binding#GO:0003723;structural constituent of ribosome#GO:0003735;binding#GO:0005488;nucleic acid binding#GO:0003676 intracellular organelle#GO:0043229;small ribosomal subunit#GO:0015935;ribonucleoprotein complex#GO:1990904;cytosolic small ribosomal subunit#GO:0022627;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;ribosome#GO:0005840;cytosol#GO:0005829;cytosolic ribosome#GO:0022626;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 ribosomal protein#PC00202 HUMAN|HGNC=26385|UniProtKB=Q8N769 Q8N769 SLIRP-OT1 PTHR48637:SF1 SECRETED PROTEIN-RELATED CHROMOSOME 14 OPEN READING FRAME 178 HUMAN|HGNC=2662|UniProtKB=P98082 P98082 DAB2 PTHR47695:SF5 PID DOMAIN-CONTAINING PROTEIN DISABLED HOMOLOG 2 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;cargo adaptor activity#GO:0140312 positive regulation of biological process#GO:0048518;positive regulation of transport#GO:0051050;cellular process#GO:0009987;regulation of canonical Wnt signaling pathway#GO:0060828;regulation of multicellular organismal process#GO:0051239;negative regulation of signal transduction#GO:0009968;vesicle-mediated transport#GO:0016192;regulation of endocytosis#GO:0030100;positive regulation of cell differentiation#GO:0045597;regulation of transport#GO:0051049;regulation of localization#GO:0032879;import into cell#GO:0098657;regulation of biological process#GO:0050789;positive regulation of multicellular organismal process#GO:0051240;negative regulation of biological process#GO:0048519;regulation of Wnt signaling pathway#GO:0030111;regulation of cellular component organization#GO:0051128;endocytosis#GO:0006897;positive regulation of cellular component organization#GO:0051130;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;negative regulation of canonical Wnt signaling pathway#GO:0090090;negative regulation of cell communication#GO:0010648;positive regulation of cellular process#GO:0048522;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of endocytosis#GO:0045807;negative regulation of Wnt signaling pathway#GO:0030178;negative regulation of response to stimulus#GO:0048585;positive regulation of developmental process#GO:0051094;transport#GO:0006810;regulation of response to stimulus#GO:0048583;regulation of cell differentiation#GO:0045595;negative regulation of cellular process#GO:0048523;receptor-mediated endocytosis#GO:0006898;establishment of localization#GO:0051234;regulation of developmental process#GO:0050793;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;localization#GO:0051179 membrane#GO:0016020;clathrin-coated pit#GO:0005905;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=25697|UniProtKB=P57764 P57764 GSDMD PTHR16399:SF15 GASDERMIN GASDERMIN-D phospholipid binding#GO:0005543;phosphatidylinositol phosphate binding#GO:1901981;binding#GO:0005488;anion binding#GO:0043168;small molecule binding#GO:0036094;phosphatidylinositol-4,5-bisphosphate binding#GO:0005546;ion binding#GO:0043167;phosphatidylinositol bisphosphate binding#GO:1902936;phosphatidylserine binding#GO:0001786;lipid binding#GO:0008289 response to external stimulus#GO:0009605;defense response#GO:0006952;response to bacterium#GO:0009617;defense response to bacterium#GO:0042742;inflammatory response#GO:0006954;response to stimulus#GO:0050896;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to other organism#GO:0051707;response to biotic stimulus#GO:0009607;response to stress#GO:0006950 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;canonical inflammasome complex#GO:0061702;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 transporter#PC00227 HUMAN|HGNC=8904|UniProtKB=O75594 O75594 PGLYRP1 PTHR11022:SF58 PEPTIDOGLYCAN RECOGNITION PROTEIN PEPTIDOGLYCAN RECOGNITION PROTEIN 1 hydrolase activity#GO:0016787;molecular transducer activity#GO:0060089;pattern recognition receptor activity#GO:0038187;N-acetylmuramoyl-L-alanine amidase activity#GO:0008745;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;peptidoglycan muralytic activity#GO:0061783;signaling receptor activity#GO:0038023;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;catalytic activity#GO:0003824 response to bacterium#GO:0009617;immune system process#GO:0002376;defense response to bacterium#GO:0042742;response to external stimulus#GO:0009605;defense response#GO:0006952;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;immune response#GO:0006955;defense response to Gram-positive bacterium#GO:0050830;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to other organism#GO:0051707 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090 HUMAN|HGNC=24954|UniProtKB=Q8WW32 Q8WW32 HMGB4 PTHR48112:SF7 HIGH MOBILITY GROUP PROTEIN DSP1 HIGH MOBILITY GROUP PROTEIN B4 cellular component organization or biogenesis#GO:0071840;chromatin remodeling#GO:0006338;chromatin organization#GO:0006325;cellular component organization#GO:0016043;cellular process#GO:0009987 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 HMG box transcription factor#PC00024;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=15836|UniProtKB=Q8NFJ6 Q8NFJ6 PROKR2 PTHR24241:SF125 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR PROKINETICIN RECEPTOR 2 molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 circadian rhythm#GO:0007623;cell communication#GO:0007154;rhythmic process#GO:0048511;G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887;signaling#GO:0023052;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;cellular response to hormone stimulus#GO:0032870;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to endogenous stimulus#GO:0009719;biological regulation#GO:0065007;response to chemical#GO:0042221;signal transduction#GO:0007165;cellular process#GO:0009987;response to hormone#GO:0009725 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=23460|UniProtKB=Q8WWB3 Q8WWB3 DYDC1 PTHR23356:SF4 DPY30-RELATED DPY30 DOMAIN-CONTAINING PROTEIN 1 organelle assembly#GO:0070925;spermatid differentiation#GO:0048515;cellular component assembly involved in morphogenesis#GO:0010927;sexual reproduction#GO:0019953;spermatid development#GO:0007286;acrosome assembly#GO:0001675;anatomical structure development#GO:0048856;multicellular organismal reproductive process#GO:0048609;developmental process involved in reproduction#GO:0003006;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;germ cell development#GO:0007281;cell differentiation#GO:0030154;gamete generation#GO:0007276;cellular process involved in reproduction in multicellular organism#GO:0022412;cell development#GO:0048468;reproductive process#GO:0022414;cellular anatomical entity morphogenesis#GO:0032989;spermatogenesis#GO:0007283;developmental process#GO:0032502;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;vesicle organization#GO:0016050;anatomical structure formation involved in morphogenesis#GO:0048646;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cellular component assembly#GO:0022607;male gamete generation#GO:0048232;endomembrane system organization#GO:0010256 cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;axoneme#GO:0005930;cilium#GO:0005929;intracellular organelle#GO:0043229;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;ciliary plasm#GO:0097014;membraneless organelle#GO:0043228;radial spoke#GO:0001534;cytoskeleton#GO:0005856 HUMAN|HGNC=329|UniProtKB=O00468 O00468 AGRN PTHR15036:SF83 PIKACHURIN-LIKE PROTEIN AGRIN protein kinase regulator activity#GO:0019887;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;signaling receptor activator activity#GO:0030546;enzyme activator activity#GO:0008047;signaling receptor regulator activity#GO:0030545;protein kinase activator activity#GO:0030295;enzyme regulator activity#GO:0030234;neurotransmitter receptor regulator activity#GO:0099602;molecular function activator activity#GO:0140677;kinase activator activity#GO:0019209;acetylcholine receptor regulator activity#GO:0030548 response to stimulus#GO:0050896;signaling#GO:0023052;cellular component organization#GO:0016043;protein localization to membrane#GO:0072657;regulation of biological process#GO:0050789;cellular localization#GO:0051641;animal gross anatomical part developmental process#GO:0160108;receptor clustering#GO:0043113;nervous system development#GO:0007399;synaptic signaling#GO:0099536;cellular process#GO:0009987;signal transduction#GO:0007165;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;neuromuscular junction development#GO:0007528;regulation of cellular process#GO:0050794;cell junction organization#GO:0034330;anterograde trans-synaptic signaling#GO:0098916;chemical synaptic transmission#GO:0007268;cellular response to stimulus#GO:0051716;anatomical structure development#GO:0048856;localization#GO:0051179;cell communication#GO:0007154;system development#GO:0048731;trans-synaptic signaling#GO:0099537;synapse organization#GO:0050808;localization within membrane#GO:0051668;multicellular organismal process#GO:0032501;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;macromolecule localization#GO:0033036;intracellular protein localization#GO:0008104;developmental process#GO:0032502 extracellular region#GO:0005576;cell junction#GO:0030054;basement membrane#GO:0005604;cell periphery#GO:0071944;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;synapse#GO:0045202 cell adhesion molecule#PC00069 HUMAN|HGNC=18108|UniProtKB=P59861 P59861 DEFB131A PTHR47900:SF1 BETA-DEFENSIN 131A BETA-DEFENSIN 131A extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 antimicrobial response protein#PC00051 HUMAN|HGNC=53893|UniProtKB=A0A024R1R8 A0A024R1R8 TMA7B PTHR28632:SF12 TRANSLATION MACHINERY-ASSOCIATED PROTEIN 7 TRANSLATION MACHINERY-ASSOCIATED PROTEIN 7B HUMAN|HGNC=13862|UniProtKB=Q9NY30 Q9NY30 BTG4 PTHR22978:SF5 B-CELL TRANSLOCATION GENE PROTEIN BTG4 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 HUMAN|HGNC=15680|UniProtKB=Q9NRC6 Q9NRC6 SPTBN5 PTHR11915:SF448 SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN SPECTRIN BETA CHAIN, NON-ERYTHROCYTIC 5 protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;actin filament binding#GO:0051015;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092 actin cytoskeleton organization#GO:0030036;cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;organelle organization#GO:0006996;actin filament-based process#GO:0030029;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;cortical actin cytoskeleton#GO:0030864;cytoplasm#GO:0005737;cytoskeleton#GO:0005856;cell junction#GO:0030054;membraneless organelle#GO:0043228;actin cytoskeleton#GO:0015629;cortical cytoskeleton#GO:0030863;cell cortex#GO:0005938;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=5730|UniProtKB=A0A0C4DH73 A0A0C4DH73 IGKV1-12 PTHR23267:SF474 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN KAPPA VARIABLE 1-12-RELATED immune system process#GO:0002376;immune response#GO:0006955;response to stimulus#GO:0050896 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=17068|UniProtKB=Q8WX93 Q8WX93 PALLD PTHR10075:SF30 BASIGIN RELATED PALLADIN cell adhesion molecule#PC00069 HUMAN|HGNC=2364|UniProtKB=O75462 O75462 CRLF1 PTHR23036:SF16 CYTOKINE RECEPTOR CYTOKINE RECEPTOR-LIKE FACTOR 1 immune receptor activity#GO:0140375;signaling receptor activity#GO:0038023;cytokine binding#GO:0019955;cytokine receptor activity#GO:0004896;molecular transducer activity#GO:0060089;protein binding#GO:0005515;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888 negative regulation of cellular process#GO:0048523;cell surface receptor signaling pathway#GO:0007166;regulation of apoptotic process#GO:0042981;response to chemical#GO:0042221;response to cytokine#GO:0034097;negative regulation of apoptotic process#GO:0043066;biological regulation#GO:0065007;negative regulation of neuron apoptotic process#GO:0043524;regulation of neuron apoptotic process#GO:0043523;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;negative regulation of programmed cell death#GO:0043069;regulation of cell population proliferation#GO:0042127;cell communication#GO:0007154;response to peptide#GO:1901652;cytokine-mediated signaling pathway#GO:0019221;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;positive regulation of cell population proliferation#GO:0008284;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;cellular response to stimulus#GO:0051716;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;extracellular region#GO:0005576;signaling receptor complex#GO:0043235;extracellular protein-containing complex#GO:0140392 transmembrane signal receptor#PC00197 HUMAN|HGNC=7153|UniProtKB=Q15546 Q15546 MMD PTHR20855:SF26 ADIPOR/PROGESTIN RECEPTOR-RELATED MONOCYTE TO MACROPHAGE DIFFERENTIATION FACTOR transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=14878|UniProtKB=Q96P09 Q96P09 BIRC8 PTHR10044:SF167 INHIBITOR OF APOPTOSIS BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 8 catalytic activity, acting on a protein#GO:0140096;molecular function regulator activity#GO:0098772;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740;enzyme regulator activity#GO:0030234;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787 regulation of apoptotic process#GO:0042981;positive regulation of protein ubiquitination#GO:0031398;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of Wnt signaling pathway#GO:0030177;regulation of canonical Wnt signaling pathway#GO:0060828;regulation of protein metabolic process#GO:0051246;positive regulation of biological process#GO:0048518;negative regulation of programmed cell death#GO:0043069;positive regulation of signaling#GO:0023056;positive regulation of metabolic process#GO:0009893;regulation of post-translational protein modification#GO:1901873;regulation of signaling#GO:0023051;positive regulation of protein metabolic process#GO:0051247;regulation of Wnt signaling pathway#GO:0030111;regulation of cell cycle#GO:0051726;regulation of protein modification by small protein conjugation or removal#GO:1903320;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;positive regulation of canonical Wnt signaling pathway#GO:0090263;regulation of protein modification process#GO:0031399;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of protein ubiquitination#GO:0031396;negative regulation of apoptotic process#GO:0043066;positive regulation of response to stimulus#GO:0048584;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of cell communication#GO:0010646;positive regulation of signal transduction#GO:0009967 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 protease inhibitor#PC00191;protein-binding activity modulator#PC00095 HUMAN|HGNC=13420|UniProtKB=Q86TP1 Q86TP1 PRUNE1 PTHR12112:SF47 BNIP - RELATED EXOPOLYPHOSPHATASE PRUNE1 hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 hydrolase#PC00121;metabolite interconversion enzyme#PC00262;phosphodiesterase#PC00185 HUMAN|HGNC=4601|UniProtKB=P28799 P28799 GRN PTHR12274:SF9 GRANULIN PROGRANULIN regulation of response to external stimulus#GO:0032101;biological regulation#GO:0065007;regulation of response to stress#GO:0080134;regulation of biological process#GO:0050789;regulation of response to stimulus#GO:0048583;regulation of inflammatory response#GO:0050727;regulation of defense response#GO:0031347 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=18443|UniProtKB=Q7Z3Z3 Q7Z3Z3 PIWIL3 PTHR22891:SF41 EUKARYOTIC TRANSLATION INITIATION FACTOR 2C PIWI-LIKE PROTEIN 3 catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;RNA endonuclease activity#GO:0004521;catalytic activity, acting on RNA#GO:0140098;RNA nuclease activity#GO:0004540;endonuclease activity#GO:0004519;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;nuclease activity#GO:0004518 RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;negative regulation of metabolic process#GO:0009892;gamete generation#GO:0007276;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;male gamete generation#GO:0048232;macromolecule biosynthetic process#GO:0009059;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulatory ncRNA processing#GO:0070918;macromolecule metabolic process#GO:0043170;spermatogenesis#GO:0007283;regulatory ncRNA-mediated gene silencing#GO:0031047;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;reproductive process#GO:0022414;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;nucleic acid metabolic process#GO:0090304;developmental process involved in reproduction#GO:0003006;primary metabolic process#GO:0044238;multicellular organismal reproductive process#GO:0048609;sexual reproduction#GO:0019953;piRNA processing#GO:0034587 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;P granule#GO:0043186;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;nucleus#GO:0005634;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;supramolecular complex#GO:0099080;organelle#GO:0043226;ribonucleoprotein granule#GO:0035770;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464 translation factor#PC00223;translation initiation factor#PC00224;translational protein#PC00263 HUMAN|HGNC=33700|UniProtKB=A6NFY4 A6NFY4 NEMP2 PTHR13598:SF3 AT07567P-RELATED NUCLEAR ENVELOPE INTEGRAL MEMBRANE PROTEIN 2 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;organelle envelope#GO:0031967;nucleus#GO:0005634 HUMAN|HGNC=14290|UniProtKB=Q8NFZ4 Q8NFZ4 NLGN2 PTHR43903:SF3 NEUROLIGIN NEUROLIGIN-2 organelle#GO:0043226;plasma membrane region#GO:0098590;postsynaptic specialization#GO:0099572;cellular anatomical structure#GO:0110165;synapse#GO:0045202;plasma membrane#GO:0005886;postsynapse#GO:0098794;membrane#GO:0016020;cell periphery#GO:0071944;cell junction#GO:0030054;postsynaptic specialization membrane#GO:0099634;postsynaptic membrane#GO:0045211;synaptic membrane#GO:0097060 cell adhesion molecule#PC00069 HUMAN|HGNC=14873|UniProtKB=Q9P0K7 Q9P0K7 RAI14 PTHR24129:SF0 ANKYCORBIN ANKYCORBIN HUMAN|HGNC=34495|UniProtKB=Q86XI8 Q86XI8 ZSWIM9 PTHR47086:SF1 BTB DOMAIN-CONTAINING PROTEIN ZINC FINGER SWIM-TYPE CONTAINING 9 HUMAN|HGNC=8301|UniProtKB=Q96R69 Q96R69 OR4F4 PTHR48002:SF51 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 4F17-RELATED transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=927|UniProtKB=O60513 O60513 B4GALT4 PTHR19300:SF9 BETA-1,4-GALACTOSYLTRANSFERASE BETA-1,4-GALACTOSYLTRANSFERASE 4 glycosyltransferase activity#GO:0016757;galactosyltransferase activity#GO:0008378;transferase activity#GO:0016740;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 metabolite interconversion enzyme#PC00262;glycosyltransferase#PC00111 HUMAN|HGNC=2773|UniProtKB=O76075 O76075 DFFB PTHR13067:SF2 CASPASE-ACTIVATED DNASE DNAATION FACTOR-RELATED PROTEIN 4 nuclease activity#GO:0004518;catalytic activity, acting on DNA#GO:0140097;DNA nuclease activity#GO:0004536;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 cellular component disassembly#GO:0022411;DNA catabolic process#GO:0006308;catabolic process#GO:0009056;cell death#GO:0008219;apoptotic process#GO:0006915;execution phase of apoptosis#GO:0097194;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;programmed cell death#GO:0012501;nucleic acid metabolic process#GO:0090304;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;macromolecule catabolic process#GO:0009057;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;nucleobase-containing compound metabolic process#GO:0006139;apoptotic DNA fragmentation#GO:0006309;nucleic acid catabolic process#GO:0141188;cellular process#GO:0009987;nucleobase-containing compound catabolic process#GO:0034655 DNA metabolism protein#PC00009 FAS signaling pathway#P00020>CAD#P00618 HUMAN|HGNC=11748|UniProtKB=Q12800 Q12800 TFCP2 PTHR11037:SF11 TRANSCRIPTION FACTOR CP2 ALPHA-GLOBIN TRANSCRIPTION FACTOR CP2 transcription regulator activity#GO:0140110;DNA-binding transcription activator activity#GO:0001216;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;sequence-specific DNA binding#GO:0043565;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific double-stranded DNA binding#GO:1990837 regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of transcription by RNA polymerase II#GO:0045944 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 DNA-binding transcription factor#PC00218 HUMAN|HGNC=28145|UniProtKB=Q9BSR8 Q9BSR8 YIPF4 PTHR21236:SF7 GOLGI MEMBRANE PROTEIN YIP1 PROTEIN YIPF4 cellular component organization#GO:0016043;Golgi organization#GO:0007030;vesicle fusion#GO:0006906;localization#GO:0051179;cellular localization#GO:0051641;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;organelle organization#GO:0006996;membrane fusion#GO:0061025;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle fusion#GO:0048284;vesicle-mediated transport#GO:0016192;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;organelle membrane fusion#GO:0090174;intracellular transport#GO:0046907;transport#GO:0006810;Golgi vesicle transport#GO:0048193;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;vesicle organization#GO:0016050 cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;Golgi apparatus subcompartment#GO:0098791;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794 structural protein#PC00211 HUMAN|HGNC=51487|UniProtKB=X6R8R1 X6R8R1 SYT15B PTHR10024:SF234 SYNAPTOTAGMIN SYNAPTOTAGMIN-15-RELATED phospholipid binding#GO:0005543;binding#GO:0005488;SNARE binding#GO:0000149;molecular sensor activity#GO:0140299;molecular function regulator activity#GO:0098772;lipid binding#GO:0008289;protein binding#GO:0005515 establishment of localization#GO:0051234;regulation of secretion#GO:0051046;localization#GO:0051179;regulation of secretion by cell#GO:1903530;regulation of exocytosis#GO:0017157;regulation of transport#GO:0051049;regulation of localization#GO:0032879;transport#GO:0006810;regulation of cellular process#GO:0050794;vesicle-mediated transport#GO:0016192;biological regulation#GO:0065007;cellular process#GO:0009987;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789 endomembrane system#GO:0012505;transport vesicle#GO:0030133;cytoplasm#GO:0005737;plasma membrane#GO:0005886;secretory vesicle#GO:0099503;membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229 membrane trafficking regulatory protein#PC00151 Synaptic vesicle trafficking#P05734>Synaptotagmin#P05769 HUMAN|HGNC=26196|UniProtKB=Q14CX5 Q14CX5 SLC68A1 PTHR28658:SF3 TRANSMEMBRANE PROTEIN 180 SOLUTE CARRIER FAMILY 68 MEMBER 1 HUMAN|HGNC=16710|UniProtKB=Q9H8T0 Q9H8T0 AKTIP PTHR24068:SF211 UBIQUITIN-CONJUGATING ENZYME E2 AKT-INTERACTING PROTEIN ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein conjugating enzyme activity#GO:0061650;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;ubiquitin conjugating enzyme activity#GO:0061631;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824 protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;cellular process#GO:0009987;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=26887|UniProtKB=Q6NXT6 Q6NXT6 TAPT1 PTHR13317:SF5 TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG positive regulation of cellular component biogenesis#GO:0044089;biological regulation#GO:0065007;regulation of organelle assembly#GO:1902115;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of cilium assembly#GO:1902017;regulation of cell projection organization#GO:0031344;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of plasma membrane bounded cell projection assembly#GO:0120032;regulation of cellular component biogenesis#GO:0044087;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;positive regulation of organelle organization#GO:0010638;regulation of cell projection assembly#GO:0060491;positive regulation of cell projection organization#GO:0031346;positive regulation of cellular component organization#GO:0051130 organelle membrane#GO:0031090;membraneless organelle#GO:0043228;endoplasmic reticulum#GO:0005783;microtubule organizing center#GO:0005815;endoplasmic reticulum membrane#GO:0005789;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;endomembrane system#GO:0012505;microtubule cytoskeleton#GO:0015630;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cilium#GO:0005929;endoplasmic reticulum subcompartment#GO:0098827;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165 HUMAN|HGNC=10672|UniProtKB=P48061 P48061 CXCL12 PTHR12015:SF193 SMALL INDUCIBLE CYTOKINE A STROMAL CELL-DERIVED FACTOR 1 cytokine#PC00083 Axon guidance mediated by Slit/Robo#P00008>Sdf1#P00346 HUMAN|HGNC=28917|UniProtKB=Q86VZ6 Q86VZ6 JAZF1 PTHR23057:SF0 JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1 JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=12853|UniProtKB=Q04917 Q04917 YWHAH PTHR18860:SF16 14-3-3 PROTEIN 14-3-3 PROTEIN ETA scaffold/adaptor protein#PC00226 FGF signaling pathway#P00021>14-3-3#P00624;EGF receptor signaling pathway#P00018>14-3-3#P00539;Parkinson disease#P00049>14-3-3#P01238 HUMAN|HGNC=5929|UniProtKB=P04211 P04211 IGLV7-43 PTHR23267:SF335 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN LAMBDA VARIABLE 7-43 response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=2080|UniProtKB=P54105 P54105 CLNS1A PTHR21399:SF3 CHLORIDE CONDUCTANCE REGULATORY PROTEIN ICLN METHYLOSOME SUBUNIT PICLN biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;cellular component biogenesis#GO:0044085;protein-containing complex organization#GO:0043933;protein-RNA complex organization#GO:0071826;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;mRNA cis splicing, via spliceosome#GO:0045292;spliceosomal snRNP assembly#GO:0000387;mRNA splicing, via spliceosome#GO:0000398;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;protein-RNA complex assembly#GO:0022618;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375 ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;spliceosomal complex#GO:0005681;nucleus#GO:0005634;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 transporter#PC00227 HUMAN|HGNC=13287|UniProtKB=A6NMB9 A6NMB9 FIGNL2 PTHR23074:SF33 AAA DOMAIN-CONTAINING FIDGETIN-LIKE PROTEIN 2 polypeptide conformation or assembly isomerase activity#GO:0120544;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP-dependent activity#GO:0140657;hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817;macromolecular conformation isomerase activity#GO:0120543;catalytic activity, acting on a protein#GO:0140096;ribonucleoside triphosphate phosphatase activity#GO:0017111;isomerase activity#GO:0016853 microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 microtubule or microtubule-binding cytoskeletal protein#PC00157;non-motor microtubule binding protein#PC00166 HUMAN|HGNC=23096|UniProtKB=Q9BZD2 Q9BZD2 SLC29A3 PTHR10332:SF17 EQUILIBRATIVE NUCLEOSIDE TRANSPORTER EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 3 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;nucleobase-containing compound transmembrane transporter activity#GO:0015932;nucleoside transmembrane transporter activity#GO:0005337;carbohydrate derivative transmembrane transporter activity#GO:1901505 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;plasma membrane#GO:0005886;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227 HUMAN|HGNC=8699|UniProtKB=O60330 O60330 PCDHGA12 PTHR24028:SF227 CADHERIN-87A PROTOCADHERIN GAMMA-A12 cellular process#GO:0009987;cell adhesion#GO:0007155 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 cadherin#PC00057;cell adhesion molecule#PC00069 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HUMAN|HGNC=6253|UniProtKB=Q9UQ05 Q9UQ05 KCNH4 PTHR10217:SF630 VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL VOLTAGE-GATED DELAYED RECTIFIER POTASSIUM CHANNEL KCNH4 monoatomic cation channel activity#GO:0005261;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;potassium channel activity#GO:0005267;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;transporter activity#GO:0005215;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249 cellular process#GO:0009987;potassium ion transport#GO:0006813;biological regulation#GO:0065007;metal ion transport#GO:0030001;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=2235|UniProtKB=Q99612 Q99612 KLF6 PTHR23235:SF50 KRUEPPEL-LIKE TRANSCRIPTION FACTOR KRUEPPEL-LIKE FACTOR 6 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=11431|UniProtKB=O14662 O14662 STX16 PTHR19957:SF83 SYNTAXIN SYNTAXIN-16 SNAP receptor activity#GO:0005484;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 vesicle fusion#GO:0006906;cellular component organization#GO:0016043;protein transport#GO:0015031;cellular localization#GO:0051641;localization#GO:0051179;organelle membrane fusion#GO:0090174;membrane organization#GO:0061024;vesicle-mediated transport#GO:0016192;organelle fusion#GO:0048284;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;organelle organization#GO:0006996;membrane fusion#GO:0061025;macromolecule localization#GO:0033036;vesicle organization#GO:0016050;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907 membrane protein complex#GO:0098796;membrane#GO:0016020;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;SNARE complex#GO:0031201;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 SNARE protein#PC00034 Nicotinic acetylcholine receptor signaling pathway#P00044>SNARE Complex#P01091;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>SNARE Complex#P01079 HUMAN|HGNC=3097|UniProtKB=O75923 O75923 DYSF PTHR12546:SF44 FER-1-LIKE DYSFERLIN animal gross anatomical part developmental process#GO:0160108;anatomical structure development#GO:0048856;plasma membrane organization#GO:0007009;wound healing#GO:0042060;cellular component organization#GO:0016043;muscle cell development#GO:0055001;muscle cell differentiation#GO:0042692;muscle structure development#GO:0061061;response to stimulus#GO:0050896;cell differentiation#GO:0030154;cell development#GO:0048468;developmental process#GO:0032502;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;response to wounding#GO:0009611;response to stress#GO:0006950;membrane fusion#GO:0061025;cellular process#GO:0009987;endomembrane system organization#GO:0010256;membrane organization#GO:0061024 intracellular organelle#GO:0043229;sarcolemma#GO:0042383;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;intracellular vesicle#GO:0097708;cell periphery#GO:0071944;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;plasma membrane#GO:0005886 membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=1405|UniProtKB=Q06432 Q06432 CACNG1 PTHR15025:SF1 VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-1 SUBUNIT-RELATED VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-1 SUBUNIT channel regulator activity#GO:0016247;molecular function regulator activity#GO:0098772;ion channel regulator activity#GO:0099106;calcium channel regulator activity#GO:0005246;transporter regulator activity#GO:0141108 regulation of monoatomic cation transmembrane transport#GO:1904062;regulation of localization#GO:0032879;regulation of transport#GO:0051049;regulation of biological process#GO:0050789;regulation of monoatomic ion transmembrane transport#GO:0034765;regulation of transmembrane transport#GO:0034762;biological regulation#GO:0065007;regulation of calcium ion transport#GO:0051924;regulation of monoatomic ion transport#GO:0043269;regulation of metal ion transport#GO:0010959;regulation of cellular process#GO:0050794 transporter complex#GO:1990351;sarcolemma#GO:0042383;transmembrane transporter complex#GO:1902495;cation channel complex#GO:0034703;plasma membrane#GO:0005886;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;calcium channel complex#GO:0034704;voltage-gated calcium channel complex#GO:0005891;membrane#GO:0016020;membrane protein complex#GO:0098796 voltage-gated ion channel#PC00241;transporter#PC00227 HUMAN|HGNC=10777|UniProtKB=Q96HF1 Q96HF1 SFRP2 PTHR11309:SF45 FRIZZLED SECRETED FRIZZLED-RELATED PROTEIN 2 binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888;Wnt-protein binding#GO:0017147;molecular transducer activity#GO:0060089;protein binding#GO:0005515;signaling receptor activity#GO:0038023 cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;canonical Wnt signaling pathway#GO:0060070;non-canonical Wnt signaling pathway#GO:0035567;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;Wnt signaling pathway#GO:0016055;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 Wnt signaling pathway#P00057>sFRP#P01434 HUMAN|HGNC=1848|UniProtKB=P19835 P19835 CEL PTHR43903:SF1 NEUROLIGIN BILE SALT-ACTIVATED LIPASE signaling receptor activity#GO:0038023;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;protein binding#GO:0005515;molecular transducer activity#GO:0060089;hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689;signaling receptor binding#GO:0005102;lipase activity#GO:0016298;binding#GO:0005488;triacylglycerol lipase activity#GO:0004806 cellular component assembly#GO:0022607;regulation of trans-synaptic signaling#GO:0099177;vesicle-mediated transport#GO:0016192;nervous system development#GO:0007399;cellular component biogenesis#GO:0044085;cell-cell adhesion#GO:0098609;synaptic signaling#GO:0099536;establishment of localization in cell#GO:0051649;lipid catabolic process#GO:0016042;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;import into cell#GO:0098657;vesicle-mediated transport in synapse#GO:0099003;metabolic process#GO:0008152;sphingolipid metabolic process#GO:0006665;synapse assembly#GO:0007416;regulation of body fluid levels#GO:0050878;endocytosis#GO:0006897;signaling#GO:0023052;cell junction assembly#GO:0034329;cellular component organization#GO:0016043;membrane assembly#GO:0071709;regulation of biological process#GO:0050789;cellular localization#GO:0051641;ceramide metabolic process#GO:0006672;regulation of biological quality#GO:0065008;animal gross anatomical part developmental process#GO:0160108;cell adhesion#GO:0007155;regulation of signaling#GO:0023051;digestion#GO:0007586;multicellular organismal process#GO:0032501;synaptic vesicle recycling#GO:0036465;membrane organization#GO:0061024;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;establishment of localization#GO:0051234;system process#GO:0003008;developmental process#GO:0032502;synaptic vesicle cycle#GO:0099504;transport#GO:0006810;lipid metabolic process#GO:0006629;catabolic process#GO:0009056;anterograde trans-synaptic signaling#GO:0098916;cell junction organization#GO:0034330;regulation of cellular process#GO:0050794;postsynapse organization#GO:0099173;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;synaptic vesicle endocytosis#GO:0048488;sphingolipid catabolic process#GO:0030149;chemical synaptic transmission#GO:0007268;primary metabolic process#GO:0044238;cell communication#GO:0007154;localization#GO:0051179;secretion#GO:0046903;anatomical structure development#GO:0048856;system development#GO:0048731;trans-synaptic signaling#GO:0099537;synapse organization#GO:0050808 cellular anatomical structure#GO:0110165;synapse#GO:0045202;cell junction#GO:0030054;cell surface#GO:0009986;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 cell adhesion molecule#PC00069 HUMAN|HGNC=17083|UniProtKB=Q15050 Q15050 RRS1 PTHR17602:SF4 RIBOSOME BIOGENESIS REGULATORY PROTEIN RIBOSOME BIOGENESIS REGULATORY PROTEIN HOMOLOG nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;ribonucleoprotein complex biogenesis#GO:0022613;maturation of 5.8S rRNA#GO:0000460;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;ribosomal large subunit biogenesis#GO:0042273;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000479;cellular component biogenesis#GO:0044085;maturation of SSU-rRNA#GO:0030490;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467;endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000447;ribosomal small subunit biogenesis#GO:0042274;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840 membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228;organelle lumen#GO:0043233;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;preribosome#GO:0030684;ribonucleoprotein complex#GO:1990904;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;preribosome, large subunit precursor#GO:0030687;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 translational protein#PC00263;ribosomal protein#PC00202 HUMAN|HGNC=18125|UniProtKB=Q96A05 Q96A05 ATP6V1E2 PTHR45715:SF7 ATPASE H+-TRANSPORTING V1 SUBUNIT E1A-RELATED V-TYPE PROTON ATPASE SUBUNIT E 2 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;proton transmembrane transporter activity#GO:0015078;active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399;monoatomic ion transmembrane transporter activity#GO:0015075;ATP-dependent activity#GO:0140657;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATPase-coupled transmembrane transporter activity#GO:0042626;monoatomic cation transmembrane transporter activity#GO:0008324 establishment of localization#GO:0051234;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;proton transmembrane transport#GO:1902600;localization#GO:0051179;monoatomic ion transport#GO:0006811;transport#GO:0006810;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;cellular process#GO:0009987 proton-transporting two-sector ATPase complex#GO:0016469;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;proton-transporting V-type ATPase complex#GO:0033176;vacuolar membrane#GO:0005774;transporter complex#GO:1990351;membrane#GO:0016020;cytoplasm#GO:0005737;vacuole#GO:0005773;protein-containing complex#GO:0032991;ATPase complex#GO:1904949;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;vacuolar proton-transporting V-type ATPase complex#GO:0016471;ATPase dependent transmembrane transport complex#GO:0098533;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transmembrane transporter complex#GO:1902495;cation-transporting ATPase complex#GO:0090533;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vacuolar proton-transporting V-type ATPase, V1 domain#GO:0000221 HUMAN|HGNC=17591|UniProtKB=Q96B33 Q96B33 CLDN23 PTHR12002:SF3 CLAUDIN CLAUDIN-23 cellular component organization or biogenesis#GO:0071840;cell-cell junction assembly#GO:0007043;cell-cell junction organization#GO:0045216;cell junction organization#GO:0034330;cellular component assembly#GO:0022607;cellular component organization#GO:0016043;cell junction assembly#GO:0034329;cellular component biogenesis#GO:0044085;cellular process#GO:0009987 apical junction complex#GO:0043296;anchoring junction#GO:0070161;tight junction#GO:0070160;cell junction#GO:0030054;cell periphery#GO:0071944;membrane#GO:0016020;cell-cell junction#GO:0005911;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;bicellular tight junction#GO:0005923 tight junction#PC00214;cell junction protein#PC00070 HUMAN|HGNC=12587|UniProtKB=P47985 P47985 UQCRFS1 PTHR10134:SF50 CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL-RELATED catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 cellular process#GO:0009987;respiratory electron transport chain#GO:0022904;mitochondrial electron transport, ubiquinol to cytochrome c#GO:0006122;mitochondrial ATP synthesis coupled electron transport#GO:0042775;electron transport chain#GO:0022900;aerobic respiration#GO:0009060;cellular respiration#GO:0045333;energy derivation by oxidation of organic compounds#GO:0015980;oxidative phosphorylation#GO:0006119;ATP synthesis coupled electron transport#GO:0042773;generation of precursor metabolites and energy#GO:0006091;aerobic electron transport chain#GO:0019646;metabolic process#GO:0008152 plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;respiratory chain complex#GO:0098803;cytochrome complex#GO:0070069;cell periphery#GO:0071944;membrane protein complex#GO:0098796;oxidoreductase complex#GO:1990204;membrane#GO:0016020;respiratory chain complex III#GO:0045275;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;catalytic complex#GO:1902494 HUMAN|HGNC=3811|UniProtKB=P55316 P55316 FOXG1 PTHR46617:SF3 FORKHEAD BOX PROTEIN G1 FORKHEAD BOX PROTEIN G1 nucleic acid binding#GO:0003676;binding#GO:0005488;double-stranded DNA binding#GO:0003690;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;sequence-specific double-stranded DNA binding#GO:1990837 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 helix-turn-helix transcription factor#PC00116;gene-specific transcriptional regulator#PC00264;winged helix/forkhead transcription factor#PC00246 HUMAN|HGNC=24164|UniProtKB=O94811 O94811 TPPP PTHR12932:SF18 P25 ALPHA-RELATED TUBULIN POLYMERIZATION-PROMOTING PROTEIN protein binding#GO:0005515;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;binding#GO:0005488 regulation of biological process#GO:0050789;protein-containing complex assembly#GO:0065003;protein polymerization#GO:0051258;regulation of protein-containing complex assembly#GO:0043254;cellular component organization#GO:0016043;regulation of cellular component biogenesis#GO:0044087;regulation of protein polymerization#GO:0032271;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;positive regulation of cellular component organization#GO:0051130;microtubule bundle formation#GO:0001578;supramolecular fiber organization#GO:0097435;microtubule cytoskeleton organization#GO:0000226;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;organelle organization#GO:0006996;microtubule polymerization or depolymerization#GO:0031109;cellular component biogenesis#GO:0044085;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;positive regulation of protein polymerization#GO:0032273;positive regulation of cellular component biogenesis#GO:0044089;microtubule-based process#GO:0007017;protein-containing complex organization#GO:0043933;microtubule polymerization#GO:0046785;cellular component organization or biogenesis#GO:0071840 intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;supramolecular complex#GO:0099080;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;microtubule cytoskeleton#GO:0015630;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 non-motor microtubule binding protein#PC00166 HUMAN|HGNC=14825|UniProtKB=Q8NH21 Q8NH21 OR4F5 PTHR48002:SF51 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 4F17-RELATED molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=6274|UniProtKB=Q9HB15 Q9HB15 KCNK12 PTHR11003:SF11 POTASSIUM CHANNEL, SUBFAMILY K POTASSIUM CHANNEL SUBFAMILY K MEMBER 12 voltage-gated monoatomic ion channel activity#GO:0005244;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;outward rectifier potassium channel activity#GO:0015271;potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261 metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;transport#GO:0006810 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=26587|UniProtKB=Q8IV35 Q8IV35 CFAP337 PTHR44324:SF1 WD40 REPEAT DOMAIN 95 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 337 HUMAN|HGNC=23480|UniProtKB=P85037 P85037 FOXK1 PTHR45881:SF4 CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED FORKHEAD BOX PROTEIN K1 HUMAN|HGNC=4711|UniProtKB=P49863 P49863 GZMK PTHR24271:SF52 KALLIKREIN-RELATED GRANZYME K peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;serine-type peptidase activity#GO:0008236 regulation of biological process#GO:0050789;cell death#GO:0008219;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;programmed cell death#GO:0012501;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell communication#GO:0007154;protein metabolic process#GO:0019538;signal transduction#GO:0007165;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;biological regulation#GO:0065007;biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 serine protease#PC00203 HUMAN|HGNC=18634|UniProtKB=Q6UXZ4 Q6UXZ4 UNC5D PTHR12582:SF5 NETRIN RECEPTOR UNC5 NETRIN RECEPTOR UNC5D molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 neuron development#GO:0048666;axonogenesis#GO:0007409;system development#GO:0048731;anatomical structure development#GO:0048856;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;cell differentiation#GO:0030154;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;neurogenesis#GO:0022008;cell projection morphogenesis#GO:0048858;neuron projection guidance#GO:0097485;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;neuron differentiation#GO:0030182;plasma membrane bounded cell projection organization#GO:0120036;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;cellular process#GO:0009987;axon development#GO:0061564;axon guidance#GO:0007411;neuron projection development#GO:0031175 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 Axon guidance mediated by netrin#P00009>UNC-5#P00356 HUMAN|HGNC=9195|UniProtKB=P52434 P52434 POLR2H PTHR10917:SF0 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3 catalytic activity, acting on RNA#GO:0140098;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772 membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;RNA polymerase II, holoenzyme#GO:0016591;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;membrane-bounded organelle#GO:0043227;transferase complex, transferring phosphorus-containing groups#GO:0061695;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;RNA polymerase I complex#GO:0005736;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;RNA polymerase III complex#GO:0005666;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;RNA polymerase II, core complex#GO:0005665;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029 DNA-directed RNA polymerase#PC00019;RNA metabolism protein#PC00031 General transcription regulation#P00023>RNA Polymerase II#P00660;Transcription regulation by bZIP transcription factor#P00055>RNA Polymerase II#P01388 HUMAN|HGNC=11855|UniProtKB=P19075 P19075 TSPAN8 PTHR19282:SF380 TETRASPANIN TETRASPANIN-8 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=2661|UniProtKB=O75553 O75553 DAB1 PTHR47695:SF4 PID DOMAIN-CONTAINING PROTEIN DISABLED HOMOLOG 1 nervous system development#GO:0007399;cell differentiation#GO:0030154;multicellular organismal process#GO:0032501;cell migration#GO:0016477;cell motility#GO:0048870;cellular process#GO:0009987;system development#GO:0048731;neurogenesis#GO:0022008;neuron migration#GO:0001764;multicellular organism development#GO:0007275;anatomical structure development#GO:0048856;cellular developmental process#GO:0048869;developmental process#GO:0032502;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229 HUMAN|HGNC=16263|UniProtKB=O14613 O14613 CDC42EP2 PTHR15344:SF4 CDC42 EFFECTOR PROTEIN BORG CDC42 EFFECTOR PROTEIN 2 small GTPase binding#GO:0031267;protein binding#GO:0005515;binding#GO:0005488;enzyme binding#GO:0019899 positive regulation of cellular component organization#GO:0051130;regulation of actin filament length#GO:0030832;regulation of biological quality#GO:0065008;positive regulation of organelle organization#GO:0010638;Rho protein signal transduction#GO:0007266;regulation of cell shape#GO:0008360;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of cellular component size#GO:0032535;regulation of protein-containing complex assembly#GO:0043254;cellular component organization#GO:0016043;regulation of cellular component biogenesis#GO:0044087;signaling#GO:0023052;regulation of plasma membrane bounded cell projection assembly#GO:0120032;response to stimulus#GO:0050896;regulation of cellular component organization#GO:0051128;regulation of anatomical structure size#GO:0090066;regulation of anatomical structure morphogenesis#GO:0022603;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;regulation of actin cytoskeleton organization#GO:0032956;intracellular signaling cassette#GO:0141124;positive regulation of cellular component biogenesis#GO:0044089;positive regulation of cell projection organization#GO:0031346;intracellular signal transduction#GO:0035556;regulation of cell projection assembly#GO:0060491;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of supramolecular fiber organization#GO:1902903;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;regulation of cytoskeleton organization#GO:0051493;regulation of protein polymerization#GO:0032271;regulation of actin filament-based process#GO:0032970;regulation of cell projection organization#GO:0031344;regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of actin filament organization#GO:0110053;positive regulation of cellular process#GO:0048522;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;regulation of actin polymerization or depolymerization#GO:0008064;positive regulation of protein polymerization#GO:0032273;regulation of actin filament polymerization#GO:0030833 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=18648|UniProtKB=Q86TI2 Q86TI2 DPP9 PTHR11731:SF109 PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED DIPEPTIDYL PEPTIDASE 9 catalytic activity#GO:0003824;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;exopeptidase activity#GO:0008238 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;cellular process#GO:0009987;proteolysis#GO:0006508;metabolic process#GO:0008152;primary metabolic process#GO:0044238 serine protease#PC00203;protease#PC00190 HUMAN|HGNC=1477|UniProtKB=Q9HC96 Q9HC96 CAPN10 PTHR10183:SF30 CALPAIN CALPAIN-10 cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;cysteine-type endopeptidase activity#GO:0004197;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 cellular process#GO:0009987;primary metabolic process#GO:0044238;metabolic process#GO:0008152;proteolysis#GO:0006508;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 cysteine protease#PC00081;protease#PC00190 Huntington disease#P00029>Calpain#P00788 HUMAN|HGNC=11730|UniProtKB=O14746 O14746 TERT PTHR12066:SF0 TELOMERASE REVERSE TRANSCRIPTASE TELOMERASE REVERSE TRANSCRIPTASE RNA-directed DNA polymerase activity#GO:0003964;RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;catalytic activity, acting on DNA#GO:0140097;DNA polymerase activity#GO:0034061;telomerase activity#GO:0003720;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a nucleic acid#GO:0140640;nucleotidyltransferase activity#GO:0016779;transferase activity#GO:0016740;catalytic activity#GO:0003824 primary metabolic process#GO:0044238;cellular component organization#GO:0016043;nucleic acid metabolic process#GO:0090304;nucleic acid biosynthetic process#GO:0141187;telomere organization#GO:0032200;DNA biosynthetic process#GO:0071897;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;organelle organization#GO:0006996;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;telomere maintenance via telomere lengthening#GO:0010833;telomere maintenance via telomerase#GO:0007004;RNA-templated DNA biosynthetic process#GO:0006278;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;nucleobase-containing compound biosynthetic process#GO:0034654;chromosome organization#GO:0051276;telomere maintenance#GO:0000723;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170 transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA metabolism protein#PC00009 HUMAN|HGNC=5247|UniProtKB=Q16082 Q16082 HSPB2 PTHR45640:SF27 HEAT SHOCK PROTEIN HSP-12.2-RELATED HEAT SHOCK PROTEIN BETA-2 protein refolding#GO:0042026;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;response to abiotic stimulus#GO:0009628;protein folding#GO:0006457;response to stimulus#GO:0050896;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;response to stress#GO:0006950;response to heat#GO:0009408;biosynthetic process#GO:0009058;response to temperature stimulus#GO:0009266;gene expression#GO:0010467;protein maturation#GO:0051604 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 chaperone#PC00072 VEGF signaling pathway#P00056>HSP27#P01412;Angiogenesis#P00005>HSP27#P00231 HUMAN|HGNC=23532|UniProtKB=Q9H987 Q9H987 SYNPO2L PTHR24217:SF10 PUTATIVE-RELATED SYNAPTOPODIN 2-LIKE PROTEIN actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;protein binding#GO:0005515 cellular component organization or biogenesis#GO:0071840;regulation of small GTPase mediated signal transduction#GO:0051056;striated muscle cell differentiation#GO:0051146;anatomical structure formation involved in morphogenesis#GO:0048646;cellular anatomical entity morphogenesis#GO:0032989;cellular component assembly#GO:0022607;positive regulation of cellular component biogenesis#GO:0044089;cytoskeleton organization#GO:0007010;regulation of actin cytoskeleton organization#GO:0032956;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;striated muscle cell development#GO:0055002;positive regulation of organelle organization#GO:0010638;regulation of intracellular signal transduction#GO:1902531;animal gross anatomical part developmental process#GO:0160108;positive regulation of cellular component organization#GO:0051130;regulation of signaling#GO:0023051;regulation of cellular component organization#GO:0051128;cell differentiation#GO:0030154;regulation of Rho protein signal transduction#GO:0035023;actomyosin structure organization#GO:0031032;cell development#GO:0048468;regulation of cellular component biogenesis#GO:0044087;regulation of actin filament bundle assembly#GO:0032231;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;cellular developmental process#GO:0048869;positive regulation of actin filament bundle assembly#GO:0032233;regulation of actin filament-based process#GO:0032970;developmental process#GO:0032502;regulation of response to stimulus#GO:0048583;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of cellular process#GO:0048522;regulation of actin filament organization#GO:0110053;anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;organelle assembly#GO:0070925;cellular component assembly involved in morphogenesis#GO:0010927;actin filament-based process#GO:0030029;sarcomere organization#GO:0045214;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794;actin cytoskeleton organization#GO:0030036;muscle structure development#GO:0061061;regulation of cell communication#GO:0010646;muscle cell development#GO:0055001;muscle cell differentiation#GO:0042692;regulation of supramolecular fiber organization#GO:1902903;myofibril assembly#GO:0030239 supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;myofibril#GO:0030016;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;actin cytoskeleton#GO:0015629;sarcomere#GO:0030017;membraneless organelle#GO:0043228;I band#GO:0031674;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;contractile muscle fiber#GO:0043292;Z disc#GO:0030018 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=29861|UniProtKB=Q9BU40 Q9BU40 CHRDL1 PTHR46303:SF2 VWFC DOMAIN-CONTAINING PROTEIN CHORDIN-LIKE PROTEIN 1 cytokine binding#GO:0019955;protein binding#GO:0005515;binding#GO:0005488 regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092;regulation of cell communication#GO:0010646;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648;cellular process#GO:0009987;regulation of BMP signaling pathway#GO:0030510;regulation of cellular response to growth factor stimulus#GO:0090287;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;negative regulation of response to stimulus#GO:0048585;developmental process#GO:0032502;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;negative regulation of BMP signaling pathway#GO:0030514;cellular developmental process#GO:0048869 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=7984|UniProtKB=O00482 O00482 NR5A2 PTHR24086:SF18 NUCLEAR RECEPTOR SUBFAMILY 5 GROUP A NUCLEAR RECEPTOR SUBFAMILY 5 GROUP A MEMBER 2 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677 developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;response to hormone#GO:0009725;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;signal transduction#GO:0007165;tissue development#GO:0009888;regulation of nucleobase-containing compound metabolic process#GO:0019219;response to chemical#GO:0042221;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;cellular response to chemical stimulus#GO:0070887;hormone-mediated signaling pathway#GO:0009755;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;cell communication#GO:0007154;regulation of RNA metabolic process#GO:0051252;response to endogenous stimulus#GO:0009719;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cellular response to hormone stimulus#GO:0032870;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;cellular response to endogenous stimulus#GO:0071495;signaling#GO:0023052 organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 zinc finger transcription factor#PC00244;C4 zinc finger nuclear receptor#PC00169;gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HUMAN|HGNC=10067|UniProtKB=P78317 P78317 RNF4 PTHR23041:SF82 RING FINGER DOMAIN-CONTAINING E3 UBIQUITIN-PROTEIN LIGASE RNF4 catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of cellular process#GO:0048522;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;nucleobase-containing compound metabolic process#GO:0006139;DNA repair#GO:0006281;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;modification-dependent protein catabolic process#GO:0019941;cellular response to stimulus#GO:0051716;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biosynthetic process#GO:0009891;protein metabolic process#GO:0019538;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;response to stress#GO:0006950;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;proteasomal protein catabolic process#GO:0010498;positive regulation of transcription by RNA polymerase II#GO:0045944;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;macromolecule catabolic process#GO:0009057;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;modification-dependent macromolecule catabolic process#GO:0043632;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557 nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;nuclear body#GO:0016604;membraneless organelle#GO:0043228;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;PML body#GO:0016605;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=3177|UniProtKB=P20800 P20800 EDN2 PTHR13874:SF9 ENDOTHELIN ENDOTHELIN-2 hormone activity#GO:0005179;molecular function activator activity#GO:0140677;protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;G protein-coupled receptor binding#GO:0001664;signaling receptor regulator activity#GO:0030545;neuropeptide receptor binding#GO:0071855;receptor ligand activity#GO:0048018 cellular homeostasis#GO:0019725;regulation of smooth muscle contraction#GO:0006940;system process#GO:0003008;intracellular calcium ion homeostasis#GO:0006874;intracellular chemical homeostasis#GO:0055082;regulation of anatomical structure size#GO:0090066;regulation of system process#GO:0044057;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;muscle contraction#GO:0006936;multicellular organismal process#GO:0032501;blood circulation#GO:0008015;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;regulation of systemic arterial blood pressure#GO:0003073;monoatomic ion homeostasis#GO:0050801;regulation of blood pressure#GO:0008217;positive regulation of biological process#GO:0048518;regulation of biological quality#GO:0065008;circulatory system process#GO:0003013;calcium ion homeostasis#GO:0055074;regulation of muscle contraction#GO:0006937;inorganic ion homeostasis#GO:0098771;homeostatic process#GO:0042592;regulation of muscle system process#GO:0090257;intracellular monoatomic ion homeostasis#GO:0006873;positive regulation of multicellular organismal process#GO:0051240;muscle system process#GO:0003012;regulation of biological process#GO:0050789 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 peptide hormone#PC00179 Endothelin signaling pathway#P00019>ET1-4#P00588;Endothelin signaling pathway#P00019>Pro ET1-4#P00571;Endothelin signaling pathway#P00019>Big ET1-4#P00574;Endothelin signaling pathway#P00019>Pre-pro ET1-4#P00576 HUMAN|Gene=P12LL_HUMAN|UniProtKB=A6NNC1 A6NNC1 PTHR15566:SF4 POM121-LIKE POM121-LIKE PROTEIN 1-RELATED HUMAN|HGNC=24930|UniProtKB=Q96HP8 Q96HP8 TMEM176A PTHR15756:SF6 LR8/HCA112 TRANSMEMBRANE PROTEIN 176A HUMAN|HGNC=2634|UniProtKB=P51589 P51589 CYP2J2 PTHR24300:SF177 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 2J2 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;heme binding#GO:0020037;catalytic activity#GO:0003824;monooxygenase activity#GO:0004497;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen#GO:0016712;binding#GO:0005488;tetrapyrrole binding#GO:0046906 cellular response to chemical stimulus#GO:0070887;response to xenobiotic stimulus#GO:0009410;metabolic process#GO:0008152;xenobiotic metabolic process#GO:0006805;cellular response to xenobiotic stimulus#GO:0071466;response to chemical#GO:0042221;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 oxidoreductase#PC00176;oxygenase#PC00177 HUMAN|HGNC=6343|UniProtKB=P21583 P21583 KITLG PTHR11574:SF0 KIT LIGAND KIT LIGAND regulation of cell population proliferation#GO:0042127;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;positive regulation of cell population proliferation#GO:0008284;regulation of biological process#GO:0050789;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 HUMAN|HGNC=19825|UniProtKB=Q6SA08 Q6SA08 TSSK4 PTHR24343:SF345 SERINE/THREONINE KINASE TESTIS-SPECIFIC SERINE_THREONINE-PROTEIN KINASE 4 transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=25490|UniProtKB=Q96HA8 Q96HA8 NTAQ1 PTHR13035:SF0 PROTEIN N-TERMINAL GLUTAMINE AMIDOHYDROLASE PROTEIN N-TERMINAL GLUTAMINE AMIDOHYDROLASE hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810 cytosol#GO:0005829;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=15567|UniProtKB=Q9UJC5 Q9UJC5 SH3BGRL2 PTHR12232:SF4 SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN 2 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=3556|UniProtKB=P12104 P12104 FABP2 PTHR11955:SF89 FATTY ACID BINDING PROTEIN FATTY ACID-BINDING PROTEIN, INTESTINAL fatty acid binding#GO:0005504;lipid binding#GO:0008289;binding#GO:0005488;anion binding#GO:0043168;small molecule binding#GO:0036094;carboxylic acid binding#GO:0031406;ion binding#GO:0043167;organic acid binding#GO:0043177 macromolecule localization#GO:0033036;lipid transport#GO:0006869;transport#GO:0006810;organic acid transport#GO:0015849;carboxylic acid transport#GO:0046942;lipid localization#GO:0010876;monocarboxylic acid transport#GO:0015718;establishment of localization#GO:0051234;localization#GO:0051179;fatty acid transport#GO:0015908 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cytosol#GO:0005829;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 transfer/carrier protein#PC00219 HUMAN|HGNC=20144|UniProtKB=Q86VK4 Q86VK4 ZNF410 PTHR46179:SF3 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 410 transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 DNA-binding transcription factor#PC00218;zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=24963|UniProtKB=Q96MG2 Q96MG2 JSRP1 PTHR22397:SF2 JUNCTIONAL SARCOPLASMIC RETICULUM PROTEIN 1 JUNCTIONAL SARCOPLASMIC RETICULUM PROTEIN 1 nervous system process#GO:0050877;neuromuscular process#GO:0050905;muscle contraction#GO:0006936;system process#GO:0003008;muscle system process#GO:0003012;multicellular organismal process#GO:0032501;striated muscle contraction#GO:0006941;skeletal muscle contraction#GO:0003009 sarcoplasmic reticulum#GO:0016529;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;sarcoplasm#GO:0016528;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=29168|UniProtKB=Q68CZ1 Q68CZ1 RPGRIP1L PTHR14240:SF4 RETINITIS PIGMENTOSA GTPASE REGULATOR-INTERACTING PROTEIN PROTEIN FANTOM protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102;G protein-coupled receptor binding#GO:0001664 cell projection organization#GO:0030030;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;cellular component organization#GO:0016043;cilium assembly#GO:0060271;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component organization or biogenesis#GO:0071840;non-motile cilium assembly#GO:1905515;cilium organization#GO:0044782;plasma membrane bounded cell projection assembly#GO:0120031;organelle assembly#GO:0070925 cilium#GO:0005929;ciliary transition zone#GO:0035869;membrane-bounded organelle#GO:0043227;non-motile cilium#GO:0097730;neuron projection#GO:0043005;photoreceptor cell cilium#GO:0097733;9+0 non-motile cilium#GO:0097731;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=23075|UniProtKB=Q9H4B0 Q9H4B0 OSGEPL1 PTHR11735:SF6 TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE, MITOCHONDRIAL mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031;RNA processing factor#PC00147 HUMAN|HGNC=8211|UniProtKB=Q8NGS1 Q8NGS1 OR1J4 PTHR48001:SF10 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 1J4 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cell communication#GO:0007154 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=21299|UniProtKB=Q5TZA2 Q5TZA2 CROCC PTHR23159:SF17 CENTROSOMAL PROTEIN 2 ROOTLETIN microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;microtubule organizing center organization#GO:0031023;cellular component organization#GO:0016043;cell cycle#GO:0007049;organelle organization#GO:0006996;cell cycle process#GO:0022402;cellular process#GO:0009987;centrosome cycle#GO:0007098;cytoskeleton organization#GO:0007010 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;centrosome#GO:0005813;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;centriole#GO:0005814;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microtubule cytoskeleton#GO:0015630 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=13249|UniProtKB=Q6ZSI9 Q6ZSI9 CAPN12 PTHR10183:SF280 CALPAIN CALPAIN-12 catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;cysteine-type endopeptidase activity#GO:0004197;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096 primary metabolic process#GO:0044238;metabolic process#GO:0008152;proteolysis#GO:0006508;cellular process#GO:0009987;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 cysteine protease#PC00081;protease#PC00190 Huntington disease#P00029>Calpain#P00788 HUMAN|HGNC=12565|UniProtKB=Q13432 Q13432 UNC119 PTHR12951:SF5 RETINAL PROTEIN 4 PROTEIN UNC-119 HOMOLOG A lipid binding#GO:0008289;binding#GO:0005488 cilium assembly#GO:0060271;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;cell cycle process#GO:0022402;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;regulation of cellular component organization#GO:0051128;cell projection organization#GO:0030030;regulation of receptor-mediated endocytosis#GO:0048259;cytokinesis#GO:0000910;cytoskeleton-dependent cytokinesis#GO:0061640;protein transport#GO:0015031;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cell projection assembly#GO:0030031;establishment of protein localization#GO:0045184;cellular component assembly#GO:0022607;regulation of endocytosis#GO:0030100;cellular component organization or biogenesis#GO:0071840;regulation of transport#GO:0051049;regulation of localization#GO:0032879;negative regulation of cellular component organization#GO:0051129;cell cycle#GO:0007049;cell division#GO:0051301;regulation of cellular process#GO:0050794;mitotic cytokinesis#GO:0000281;negative regulation of transport#GO:0051051;mitotic cell cycle#GO:0000278;organelle assembly#GO:0070925;localization#GO:0051179;macromolecule localization#GO:0033036;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;plasma membrane bounded cell projection assembly#GO:0120031;transport#GO:0006810;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;mitotic cell cycle process#GO:1903047 microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;centrosome#GO:0005813;microtubule organizing center#GO:0005815;spindle#GO:0005819;membraneless organelle#GO:0043228;spindle pole#GO:0000922;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;intracellular organelle#GO:0043229;cilium#GO:0005929;spindle midzone#GO:0051233;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 membrane traffic protein#PC00150 HUMAN|HGNC=723|UniProtKB=P52961 P52961 ART1 PTHR10339:SF19 ADP-RIBOSYLTRANSFERASE GPI-LINKED NAD(P)(+)--ARGININE ADP-RIBOSYLTRANSFERASE 1 pentosyltransferase activity#GO:0016763;transferase activity#GO:0016740;catalytic activity#GO:0003824;NAD+ poly-ADP-ribosyltransferase activity#GO:0003950;glycosyltransferase activity#GO:0016757 transferase#PC00220 HUMAN|HGNC=30359|UniProtKB=Q9Y534 Q9Y534 CSDC2 PTHR12962:SF4 CALCIUM-REGULATED HEAT STABLE PROTEIN CRHSP-24-RELATED COLD SHOCK DOMAIN-CONTAINING PROTEIN C2 mRNA 3'-UTR binding#GO:0003730;RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729 regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of mRNA stability#GO:0043488;regulation of mRNA catabolic process#GO:0061013;regulation of biological process#GO:0050789;regulation of biological quality#GO:0065008;regulation of RNA metabolic process#GO:0051252;regulation of RNA stability#GO:0043487;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biosynthetic process#GO:0009889;regulation of mRNA metabolic process#GO:1903311;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;post-transcriptional regulation of gene expression#GO:0010608 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031 HUMAN|HGNC=10493|UniProtKB=P33764 P33764 S100A3 PTHR11639:SF12 S100 CALCIUM-BINDING PROTEIN PROTEIN S100-A3 metal ion binding#GO:0046872;protein binding#GO:0005515;cation binding#GO:0043169;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;calcium ion binding#GO:0005509 calmodulin-related#PC00061;calcium-binding protein#PC00060 HUMAN|HGNC=27828|UniProtKB=Q629K1 Q629K1 TRIQK PTHR20583:SF1 TRIPLE QXXK/R MOTIF-CONTAINING PROTEIN TRIPLE QXXK_R MOTIF-CONTAINING PROTEIN HUMAN|HGNC=25043|UniProtKB=Q9H7L2 Q9H7L2 KIR3DX1 PTHR11738:SF196 MHC CLASS I NK CELL RECEPTOR KILLER CELL IMMUNOGLOBULIN-LIKE RECEPTOR-LIKE PROTEIN KIR3DX1-RELATED transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;immune receptor activity#GO:0140375;signaling receptor activity#GO:0038023 signaling#GO:0023052;immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;response to stimulus#GO:0050896;immune response-regulating signaling pathway#GO:0002764;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154;regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166;regulation of immune response#GO:0050776 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=26527|UniProtKB=Q68CP4 Q68CP4 HGSNAT PTHR31061:SF37 LD22376P HEPARAN-ALPHA-GLUCOSAMINIDE N-ACETYLTRANSFERASE acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824;acetyltransferase activity#GO:0016407;N-acetyltransferase activity#GO:0008080 catabolic process#GO:0009056;carbohydrate derivative catabolic process#GO:1901136;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;proteoglycan metabolic process#GO:0006029;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;glycoprotein metabolic process#GO:0009100;protein catabolic process#GO:0030163 bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;lytic vacuole#GO:0000323;vacuolar membrane#GO:0005774;vacuole#GO:0005773;cytoplasm#GO:0005737;lysosomal membrane#GO:0005765;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;lysosome#GO:0005764;lytic vacuole membrane#GO:0098852 HUMAN|HGNC=20593|UniProtKB=Q96JC1 Q96JC1 VPS39 PTHR12894:SF49 CNH DOMAIN CONTAINING VAM6_VPS39-LIKE PROTEIN enzyme binding#GO:0019899;binding#GO:0005488;protein binding#GO:0005515;small GTPase binding#GO:0031267 catabolic process#GO:0009056;protein-containing complex disassembly#GO:0032984;cellular component organization#GO:0016043;localization#GO:0051179;cellular component disassembly#GO:0022411;vacuole organization#GO:0007033;process utilizing autophagic mechanism#GO:0061919;vacuole fusion#GO:0097576;organelle fusion#GO:0048284;vesicle-mediated transport#GO:0016192;macroautophagy#GO:0016236;organelle organization#GO:0006996;autophagy#GO:0006914;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;protein-containing complex organization#GO:0043933;metabolic process#GO:0008152;autophagosome maturation#GO:0097352;transport#GO:0006810 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;lysosome#GO:0005764;membrane protein complex#GO:0098796;lytic vacuole membrane#GO:0098852;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;vacuole#GO:0005773;protein-containing complex#GO:0032991;lysosomal membrane#GO:0005765;membrane#GO:0016020;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;vesicle tethering complex#GO:0099023;vacuolar membrane#GO:0005774;lytic vacuole#GO:0000323 HUMAN|HGNC=24531|UniProtKB=P60006 P60006 ANAPC15 PTHR22526:SF4 ANAPHASE PROMOTING COMPLEX C SUBUNIT 15, PSEUDOGENE-RELATED ANAPHASE-PROMOTING COMPLEX SUBUNIT 15 regulation of mitotic cell cycle#GO:0007346;regulation of nuclear division#GO:0051783;biological regulation#GO:0065007;regulation of cell cycle process#GO:0010564;regulation of signal transduction#GO:0009966;regulation of mitotic metaphase/anaphase transition#GO:0030071;regulation of chromosome separation#GO:1905818;regulation of response to stimulus#GO:0048583;regulation of chromosome segregation#GO:0051983;regulation of chromosome organization#GO:0033044;regulation of mitotic nuclear division#GO:0007088;regulation of mitotic sister chromatid separation#GO:0010965;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of cell cycle phase transition#GO:1901987;regulation of cell communication#GO:0010646;regulation of sister chromatid segregation#GO:0033045;regulation of cell cycle#GO:0051726;regulation of cellular process#GO:0050794;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;regulation of cellular component organization#GO:0051128;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;regulation of mitotic sister chromatid segregation#GO:0033047;regulation of mitotic cell cycle phase transition#GO:1901990 transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;nucleus#GO:0005634;protein-containing complex#GO:0032991;anaphase-promoting complex#GO:0005680;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ubiquitin ligase complex#GO:0000151;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;nuclear ubiquitin ligase complex#GO:0000152;cellular anatomical structure#GO:0110165;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=10363|UniProtKB=P18124 P18124 RPL7 PTHR11524:SF12 60S RIBOSOMAL PROTEIN L7 LARGE RIBOSOMAL SUBUNIT PROTEIN UL30 RNA binding#GO:0003723;structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;binding#GO:0005488 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;nucleic acid biosynthetic process#GO:0141187;ribosomal large subunit biogenesis#GO:0042273;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;biosynthetic process#GO:0009058;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;maturation of LSU-rRNA#GO:0000470;gene expression#GO:0010467;metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170 cytosol#GO:0005829;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625;ribosome#GO:0005840;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202 HUMAN|HGNC=662|UniProtKB=Q13795 Q13795 ARFRP1 PTHR45909:SF1 ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1 ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1 hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817 vesicle-mediated transport#GO:0016192;macromolecule localization#GO:0033036;establishment of protein localization to membrane#GO:0090150;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;establishment of localization#GO:0051234;vesicle-mediated transport to the plasma membrane#GO:0098876;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;protein localization to cell periphery#GO:1990778;protein localization to Golgi apparatus#GO:0034067;transport#GO:0006810;intracellular protein transport#GO:0006886;Golgi vesicle transport#GO:0048193;protein localization to organelle#GO:0033365;Golgi to plasma membrane transport#GO:0006893;Golgi to plasma membrane protein transport#GO:0043001;protein localization to plasma membrane#GO:0072659;protein localization to membrane#GO:0072657;cellular localization#GO:0051641;localization#GO:0051179;protein transport#GO:0015031;post-Golgi vesicle-mediated transport#GO:0006892;localization within membrane#GO:0051668;establishment of protein localization to plasma membrane#GO:0061951 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=14361|UniProtKB=P78411 P78411 IRX5 PTHR11211:SF17 IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX-5 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;neuron differentiation#GO:0030182;developmental process#GO:0032502;nervous system development#GO:0007399;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=6530|UniProtKB=P09848 P09848 LCT PTHR10353:SF38 GLYCOSYL HYDROLASE LACTASE_PHLORIZIN HYDROLASE beta-glucosidase activity#GO:0008422;glucosidase activity#GO:0015926;catalytic activity#GO:0003824;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787 carbohydrate catabolic process#GO:0016052;oligosaccharide metabolic process#GO:0009311;metabolic process#GO:0008152;catabolic process#GO:0009056;oligosaccharide catabolic process#GO:0009313;carbohydrate metabolic process#GO:0005975;primary metabolic process#GO:0044238;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;apical plasma membrane#GO:0016324;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;plasma membrane region#GO:0098590;external side of plasma membrane#GO:0009897;apical part of cell#GO:0045177;side of membrane#GO:0098552 glycosidase#PC00110;hydrolase#PC00121;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=14234|UniProtKB=Q96L73 Q96L73 NSD1 PTHR22884:SF312 SET DOMAIN PROTEINS HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-36 SPECIFIC lysine N-methyltransferase activity#GO:0016278;histone modifying activity#GO:0140993;histone H3 methyltransferase activity#GO:0140938;protein-lysine N-methyltransferase activity#GO:0016279;histone methyltransferase activity#GO:0042054;N-methyltransferase activity#GO:0008170;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;catalytic activity, acting on a protein#GO:0140096;histone H3K36 methyltransferase activity#GO:0046975;protein methyltransferase activity#GO:0008276;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring one-carbon groups#GO:0016741 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;chromatin#GO:0000785;nucleus#GO:0005634;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=10696|UniProtKB=O00471 O00471 EXOC5 PTHR12100:SF4 SEC10 EXOCYST COMPLEX COMPONENT 5 cellular process#GO:0009987;export from cell#GO:0140352;vesicle-mediated transport#GO:0016192;transport#GO:0006810;secretion by cell#GO:0032940;exocytosis#GO:0006887;localization#GO:0051179;secretion#GO:0046903;establishment of localization#GO:0051234 vesicle tethering complex#GO:0099023;intracellular anatomical structure#GO:0005622;cell cortex#GO:0005938;cell periphery#GO:0071944;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;exocyst#GO:0000145 membrane trafficking regulatory protein#PC00151;membrane traffic protein#PC00150 HUMAN|HGNC=26400|UniProtKB=Q5T8I9 Q5T8I9 HENMT1 PTHR21404:SF3 HEN1 SMALL RNA 2'-O-METHYLTRANSFERASE HUMAN|HGNC=685|UniProtKB=Q15052 Q15052 ARHGEF6 PTHR46026:SF2 RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 6 enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cell projection organization#GO:0030030;cell projection assembly#GO:0030031;lamellipodium assembly#GO:0030032;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection assembly#GO:0120031 cell leading edge#GO:0031252;cellular anatomical structure#GO:0110165;lamellipodium#GO:0030027;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995 protein-binding activity modulator#PC00095;G-protein modulator#PC00022;guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=26345|UniProtKB=Q96LL4 Q96LL4 C8orf48 PTHR35256:SF1 CHROMOSOME 8 OPEN READING FRAME 48 SIMILAR TO HUMAN CHROMOSOME 8 OPEN READING FRAME 48 HUMAN|HGNC=45147|UniProtKB=F8VTS6 F8VTS6 RFPL4AL1 PTHR24103:SF666 E3 UBIQUITIN-PROTEIN LIGASE TRIM RET FINGER PROTEIN-LIKE 4A-RELATED ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824 immune system process#GO:0002376;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;response to external stimulus#GO:0009605;defense response#GO:0006952;regulation of gene expression#GO:0010468;innate immune response#GO:0045087;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;response to other organism#GO:0051707;defense response to other organism#GO:0098542;defense response to symbiont#GO:0140546;immune response#GO:0006955;response to biotic stimulus#GO:0009607;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;response to stress#GO:0006950 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=14439|UniProtKB=Q96Q35 Q96Q35 FLACC1 PTHR21707:SF42 FLAGELLUM-ASSOCIATED COILED-COIL DOMAIN-CONTAINING PROTEIN 1 FLAGELLUM-ASSOCIATED COILED-COIL DOMAIN-CONTAINING PROTEIN 1 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=6421|UniProtKB=P19012 P19012 KRT15 PTHR23239:SF164 INTERMEDIATE FILAMENT KERATIN, TYPE I CYTOSKELETAL 15 structural molecule activity#GO:0005198 morphogenesis of an epithelium#GO:0002009;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;developmental process#GO:0032502;cytoskeleton organization#GO:0007010;tissue development#GO:0009888;epithelial cell differentiation#GO:0030855;epithelium development#GO:0060429;cellular process#GO:0009987;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;anatomical structure development#GO:0048856;tissue morphogenesis#GO:0048729;intermediate filament organization#GO:0045109;animal gross anatomical part developmental process#GO:0160108;intermediate filament-based process#GO:0045103;cell differentiation#GO:0030154;intermediate filament cytoskeleton organization#GO:0045104;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043 organelle#GO:0043226;supramolecular complex#GO:0099080;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;intermediate filament#GO:0005882;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622 intermediate filament#PC00129 HUMAN|HGNC=15952|UniProtKB=Q9NQ03 Q9NQ03 SCRT2 PTHR24388:SF48 ZINC FINGER PROTEIN TRANSCRIPTIONAL REPRESSOR SCRATCH 2 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=12298|UniProtKB=P20396 P20396 TRH PTHR17530:SF2 PRO-THYROTROPIN-RELEASING HORMONE PRO-THYROTROPIN-RELEASING HORMONE receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;signaling receptor activator activity#GO:0030546;hormone activity#GO:0005179;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772 secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;secretory vesicle#GO:0099503 peptide hormone#PC00179 Thyrotropin-releasing hormone receptor signaling pathway#P04394>ProTRH (Pro Thyrotropin-releasing Hormone)#P04586;Thyrotropin-releasing hormone receptor signaling pathway#P04394>TRH#P04585 HUMAN|HGNC=19003|UniProtKB=Q96GD3 Q96GD3 SCMH1 PTHR12247:SF68 POLYCOMB GROUP PROTEIN POLYCOMB PROTEIN SCMH1 protein binding#GO:0005515;histone binding#GO:0042393;chromatin binding#GO:0003682;binding#GO:0005488 regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=4370|UniProtKB=Q9Y692 Q9Y692 GMEB1 PTHR10417:SF3 GLUCOCORTICOID MODULATORY ELEMENT-BINDING PROTEIN GLUCOCORTICOID MODULATORY ELEMENT-BINDING PROTEIN 1 sequence-specific double-stranded DNA binding#GO:1990837;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;sequence-specific DNA binding#GO:0043565;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;DNA-binding transcription activator activity#GO:0001216;transcription regulator activity#GO:0140110 positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=33547|UniProtKB=Q8TBE3 Q8TBE3 FNDC9 PTHR37361:SF2 FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN 9 FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN 9 HUMAN|HGNC=15174|UniProtKB=Q8NGI4 Q8NGI4 OR4D11 PTHR48002:SF89 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 4D11 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=9716|UniProtKB=Q9NR77 Q9NR77 PXMP2 PTHR11266:SF134 PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17 PEROXISOMAL MEMBRANE PROTEIN 2 organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;peroxisomal membrane#GO:0005778;cellular anatomical structure#GO:0110165;organelle#GO:0043226;microbody#GO:0042579;membrane#GO:0016020;peroxisome#GO:0005777 transporter#PC00227 HUMAN|HGNC=17366|UniProtKB=Q9UDR5 Q9UDR5 AASS PTHR11133:SF28 SACCHAROPINE DEHYDROGENASE ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;proteinogenic amino acid metabolic process#GO:0170039;small molecule catabolic process#GO:0044282;amino acid metabolic process#GO:0006520 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 dehydrogenase#PC00092 HUMAN|HGNC=29174|UniProtKB=Q2M389 Q2M389 WASHC4 PTHR31409:SF0 WASH COMPLEX SUBUNIT 4 WASH COMPLEX SUBUNIT 4 vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;endosomal transport#GO:0016197;intracellular transport#GO:0046907;transport#GO:0006810 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;vesicle#GO:0031982;intracellular vesicle#GO:0097708;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;intracellular organelle#GO:0043229 HUMAN|HGNC=12299|UniProtKB=P34981 P34981 TRHR PTHR46061:SF2 THYROTROPIN-RELEASING HORMONE RECEPTOR THYROTROPIN-RELEASING HORMONE RECEPTOR transmembrane signaling receptor activity#GO:0004888;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 G protein-coupled receptor signaling pathway#GO:0007186;phospholipase C-activating G protein-coupled receptor signaling pathway#GO:0007200;cell communication#GO:0007154;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 C4 zinc finger nuclear receptor#PC00169;gene-specific transcriptional regulator#PC00264 Thyrotropin-releasing hormone receptor signaling pathway#P04394>TRH Receptor#P04580 HUMAN|HGNC=5239|UniProtKB=P17066 P17066 HSPA6 PTHR19375:SF553 HEAT SHOCK PROTEIN 70KDA HEAT SHOCK 70 KDA PROTEIN 6-RELATED ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;heat shock protein binding#GO:0031072;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;protein binding#GO:0005515;ATP hydrolysis activity#GO:0016887;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;ATP-dependent activity#GO:0140657 protein maturation#GO:0051604;gene expression#GO:0010467;protein folding#GO:0006457;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;protein refolding#GO:0042026;metabolic process#GO:0008152 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 Hsp70 family chaperone#PC00027;chaperone#PC00072 Parkinson disease#P00049>Hsp70#P01208;Apoptosis signaling pathway#P00006>HSP70#P00321 HUMAN|HGNC=18594|UniProtKB=Q969R5 Q969R5 L3MBTL2 PTHR12247:SF64 POLYCOMB GROUP PROTEIN LETHAL(3)MALIGNANT BRAIN TUMOR-LIKE PROTEIN 2 histone binding#GO:0042393;chromatin binding#GO:0003682;binding#GO:0005488;protein binding#GO:0005515 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of metabolic process#GO:0009892;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=2477|UniProtKB=P28325 P28325 CST5 PTHR46186:SF1 CYSTATIN CYSTATIN-D peptidase regulator activity#GO:0061134;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;cysteine-type endopeptidase inhibitor activity#GO:0004869;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;enzyme inhibitor activity#GO:0004857;molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;extracellular region#GO:0005576;vesicle#GO:0031982 protease inhibitor#PC00191 HUMAN|HGNC=29675|UniProtKB=Q96S66 Q96S66 CLCC1 PTHR34093:SF1 CHLORIDE CHANNEL CLIC-LIKE PROTEIN 1 CHLORIDE CHANNEL CLIC-LIKE PROTEIN 1 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic anion transmembrane transporter activity#GO:0008509;passive transmembrane transporter activity#GO:0022803;chloride transmembrane transporter activity#GO:0015108;chloride channel activity#GO:0005254;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;monoatomic anion channel activity#GO:0005253 cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;calcium ion homeostasis#GO:0055074;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;inorganic ion homeostasis#GO:0098771;chemical homeostasis#GO:0048878;homeostatic process#GO:0042592;monoatomic ion homeostasis#GO:0050801;intracellular monoatomic ion homeostasis#GO:0006873 endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=10360|UniProtKB=P46777 P46777 RPL5 PTHR23410:SF24 RIBOSOMAL PROTEIN L5-RELATED LARGE RIBOSOMAL SUBUNIT PROTEIN UL18 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 biological regulation#GO:0065007;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;ribosomal large subunit assembly#GO:0000027;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;post-transcriptional regulation of gene expression#GO:0010608;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of translation#GO:0045727;positive regulation of biosynthetic process#GO:0009891;protein-RNA complex assembly#GO:0022618;organelle assembly#GO:0070925;positive regulation of macromolecule metabolic process#GO:0010604;cellular component assembly#GO:0022607;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;regulation of protein metabolic process#GO:0051246;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;protein-RNA complex organization#GO:0071826;ribonucleoprotein complex biogenesis#GO:0022613;protein-containing complex assembly#GO:0065003;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of protein metabolic process#GO:0051247;ribosomal large subunit biogenesis#GO:0042273;ribosome assembly#GO:0042255;ribosome biogenesis#GO:0042254 cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;ribosome#GO:0005840;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904 ribosomal protein#PC00202 HUMAN|HGNC=29171|UniProtKB=Q6IPM2 Q6IPM2 IQCE PTHR22590:SF3 MYOSIN MOTOR DOMAIN-CONTAINING PROTEIN IQ DOMAIN-CONTAINING PROTEIN E HUMAN|HGNC=28404|UniProtKB=Q6P3S1 Q6P3S1 DENND1B PTHR13196:SF24 DENN DOMAIN-CONTAINING DENN DOMAIN-CONTAINING PROTEIN 1B lipid binding#GO:0008289;phosphatidylinositol phosphate binding#GO:1901981;phospholipid binding#GO:0005543;binding#GO:0005488 localization#GO:0051179;cell communication#GO:0007154;localization within membrane#GO:0051668;regulation of immune response#GO:0050776;immune response-activating cell surface receptor signaling pathway#GO:0002429;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;cellular response to stimulus#GO:0051716;vesicle-mediated transport to the plasma membrane#GO:0098876;establishment of localization#GO:0051234;transport#GO:0006810;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;intracellular transport#GO:0046907;T cell receptor signaling pathway#GO:0050852;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;positive regulation of response to stimulus#GO:0048584;cellular localization#GO:0051641;immune system process#GO:0002376;signaling#GO:0023052;endocytosis#GO:0006897;response to stimulus#GO:0050896;endocytic recycling#GO:0032456;immune response-regulating signaling pathway#GO:0002764;regulation of biological process#GO:0050789;endosomal transport#GO:0016197;import into cell#GO:0098657;immune response-activating signaling pathway#GO:0002757;cell surface receptor signaling pathway#GO:0007166;vesicle-mediated transport#GO:0016192;antigen receptor-mediated signaling pathway#GO:0050851;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;establishment of localization in cell#GO:0051649;activation of immune response#GO:0002253;positive regulation of immune system process#GO:0002684 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=28503|UniProtKB=Q8N755 Q8N755 SLC66A3 PTHR12226:SF3 MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 LEC35 -RELATED SOLUTE CARRIER FAMILY 66 MEMBER 3 HUMAN|HGNC=10798|UniProtKB=Q8IWL2 Q8IWL2 SFTPA1 PTHR24024:SF13 PULMONARY SURFACTANT-ASSOCIATED PROTEIN A PULMONARY SURFACTANT-ASSOCIATED PROTEIN A1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;pattern recognition receptor activity#GO:0038187 response to external stimulus#GO:0009605;defense response#GO:0006952;innate immune response#GO:0045087;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;biological regulation#GO:0065007;response to other organism#GO:0051707;positive regulation of response to stimulus#GO:0048584;positive regulation of endocytosis#GO:0045807;positive regulation of cellular process#GO:0048522;complement activation#GO:0006956;immune response#GO:0006955;regulation of immune response#GO:0050776;response to external biotic stimulus#GO:0043207;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of transport#GO:0051049;regulation of localization#GO:0032879;regulation of endocytosis#GO:0030100;immune effector process#GO:0002252;humoral immune response#GO:0006959;defense response to other organism#GO:0098542;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;defense response to symbiont#GO:0140546;positive regulation of transport#GO:0051050;response to biotic stimulus#GO:0009607;positive regulation of immune system process#GO:0002684;response to stress#GO:0006950;positive regulation of cellular component organization#GO:0051130;immune system process#GO:0002376;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;regulation of cellular component organization#GO:0051128;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 structural protein#PC00211;surfactant#PC00212 HUMAN|HGNC=27400|UniProtKB=Q8N431 Q8N431 RASGEF1C PTHR23113:SF186 GUANINE NUCLEOTIDE EXCHANGE FACTOR RAS-GEF DOMAIN-CONTAINING FAMILY MEMBER 1C guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589 Ras protein signal transduction#GO:0007265;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;intracellular signaling cassette#GO:0141124;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=8268|UniProtKB=Q96R28 Q96R28 OR2M2 PTHR26453:SF639 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2M2 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 detection of chemical stimulus#GO:0009593;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;response to stimulus#GO:0050896;response to chemical#GO:0042221;nervous system process#GO:0050877;sensory perception#GO:0007600;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;system process#GO:0003008 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=19911|UniProtKB=Q5T6F0 Q5T6F0 DCAF12 PTHR19860:SF10 DDB1- AND CUL4-ASSOCIATED FACTOR 12-RELATED DDB1- AND CUL4-ASSOCIATED FACTOR 12 catalytic complex#GO:1902494;transferase complex#GO:1990234;Cul4-RING E3 ubiquitin ligase complex#GO:0080008;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991 HUMAN|HGNC=30131|UniProtKB=Q6ZVX9 Q6ZVX9 PAQR9 PTHR20855:SF143 ADIPOR/PROGESTIN RECEPTOR-RELATED MEMBRANE PROGESTIN RECEPTOR EPSILON signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=3389|UniProtKB=P54756 P54756 EPHA5 PTHR46877:SF13 EPH RECEPTOR A5 EPHRIN TYPE-A RECEPTOR 5 transmembrane signaling receptor activity#GO:0004888;phosphotransferase activity, alcohol group as acceptor#GO:0016773;molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714;protein kinase activity#GO:0004672;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein tyrosine kinase activity#GO:0004713;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;signaling receptor activity#GO:0038023;transmembrane receptor protein kinase activity#GO:0019199 neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;multicellular organismal process#GO:0032501;axon development#GO:0061564;axon guidance#GO:0007411;system development#GO:0048731;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of cellular process#GO:0050794;ephrin receptor signaling pathway#GO:0048013;cellular response to stimulus#GO:0051716;cell projection morphogenesis#GO:0048858;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell surface receptor signaling pathway#GO:0007166;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;signal transduction#GO:0007165;cellular process#GO:0009987;neuron projection development#GO:0031175;neuron development#GO:0048666;axonogenesis#GO:0007409;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;signaling#GO:0023052;cell development#GO:0048468;response to stimulus#GO:0050896;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell morphogenesis#GO:0000902;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cellular component organization#GO:0016043 plasma membrane bounded cell projection#GO:0120025;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;neuron projection#GO:0043005;membrane#GO:0016020;dendritic tree#GO:0097447;dendrite#GO:0030425 transmembrane signal receptor#PC00197 HUMAN|HGNC=34395|UniProtKB=A6PVY3 A6PVY3 FAM177B PTHR31206:SF9 LP10445P PROTEIN FAM177B HUMAN|HGNC=13174|UniProtKB=A6NK75 A6NK75 ZNF98 PTHR24384:SF108 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED ZINC FINGER PROTEIN 492-RELATED sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218 HUMAN|HGNC=7464|UniProtKB=P49286 P49286 MTNR1B PTHR24228:SF54 B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR MELATONIN RECEPTOR TYPE 1B molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 signaling#GO:0023052;regulation of cell communication#GO:0010646;response to stimulus#GO:0050896;regulation of protein transport#GO:0051223;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of hormone levels#GO:0010817;regulation of protein secretion#GO:0050708;cellular response to stimulus#GO:0051716;regulation of protein localization#GO:0032880;regulation of establishment of protein localization#GO:0070201;regulation of biological quality#GO:0065008;regulation of secretion by cell#GO:1903530;regulation of hormone secretion#GO:0046883;cell communication#GO:0007154;regulation of secretion#GO:0051046;regulation of signaling#GO:0023051;G protein-coupled receptor signaling pathway#GO:0007186;biological regulation#GO:0065007;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of insulin secretion#GO:0050796;regulation of localization#GO:0032879;regulation of transport#GO:0051049 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711 HUMAN|HGNC=4169|UniProtKB=O60861 O60861 GAS7 PTHR23065:SF57 PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1 GROWTH ARREST-SPECIFIC PROTEIN 7 clathrin-dependent endocytosis#GO:0072583;system development#GO:0048731;localization#GO:0051179;anatomical structure development#GO:0048856;plasma membrane bounded cell projection organization#GO:0120036;multicellular organismal process#GO:0032501;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;transport#GO:0006810;receptor-mediated endocytosis#GO:0006898;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;establishment of localization#GO:0051234;protein-containing complex assembly#GO:0065003;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;cell development#GO:0048468;cell differentiation#GO:0030154;cell projection organization#GO:0030030;endocytosis#GO:0006897;cell morphogenesis#GO:0000902;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;neuron development#GO:0048666;cellular process#GO:0009987;neuron projection development#GO:0031175;cellular component biogenesis#GO:0044085;nervous system development#GO:0007399;cellular component assembly#GO:0022607;vesicle-mediated transport#GO:0016192;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell projection morphogenesis#GO:0048858;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;import into cell#GO:0098657 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;coated vesicle#GO:0030135;clathrin-coated pit#GO:0005905;intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;clathrin-coated vesicle#GO:0030136;membrane#GO:0016020;cell periphery#GO:0071944;endomembrane system#GO:0012505;plasma membrane#GO:0005886;cytoplasm#GO:0005737 actin or actin-binding cytoskeletal protein#PC00041;cytoskeletal protein#PC00085 HUMAN|HGNC=29433|UniProtKB=Q5QGS0 Q5QGS0 NEXMIF PTHR46946:SF1 NEURITE EXTENSION AND MIGRATION FACTOR NEURITE EXTENSION AND MIGRATION FACTOR regulation of cell motility#GO:2000145;regulation of cell-matrix adhesion#GO:0001952;regulation of cellular process#GO:0050794;regulation of cell-cell adhesion#GO:0022407;regulation of cell adhesion mediated by integrin#GO:0033628;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of cell migration#GO:0030334;negative regulation of cellular process#GO:0048523;negative regulation of cell migration#GO:0030336;regulation of neuron migration#GO:2001222;regulation of locomotion#GO:0040012;biological regulation#GO:0065007;negative regulation of cell motility#GO:2000146;negative regulation of locomotion#GO:0040013;regulation of cell-substrate adhesion#GO:0010810;regulation of cell adhesion#GO:0030155;negative regulation of cell adhesion#GO:0007162;negative regulation of cell-cell adhesion#GO:0022408 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=11953|UniProtKB=Q92752 Q92752 TNR PTHR19143:SF254 FIBRINOGEN/TENASCIN/ANGIOPOEITIN TENASCIN-R animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502;multicellular organism development#GO:0007275;multicellular organismal process#GO:0032501;anatomical structure development#GO:0048856;system development#GO:0048731;nervous system development#GO:0007399 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012 intercellular signal molecule#PC00207 HUMAN|HGNC=26913|UniProtKB=Q8NBT2 Q8NBT2 SPC24 PTHR22142:SF2 KINETOCHORE PROTEIN SPC24 KINETOCHORE PROTEIN SPC24 microtubule binding#GO:0008017;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;protein binding#GO:0005515 cellular process#GO:0009987;cell cycle process#GO:0022402;chromosome segregation#GO:0007059;cell cycle#GO:0007049 condensed chromosome#GO:0000793;chromosome, centromeric region#GO:0000775;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;outer kinetochore#GO:0000940;intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687;condensed chromosome, centromeric region#GO:0000779;chromosome#GO:0005694;kinetochore#GO:0000776;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;supramolecular complex#GO:0099080;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232 HUMAN|HGNC=14576|UniProtKB=O15068 O15068 MCF2L PTHR22826:SF115 RHO GUANINE EXCHANGE FACTOR-RELATED GUANINE NUCLEOTIDE EXCHANGE FACTOR DBS molecular function regulator activity#GO:0098772;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;guanyl-nucleotide exchange factor activity#GO:0005085 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 guanyl-nucleotide exchange factor#PC00113;protein-binding activity modulator#PC00095 HUMAN|HGNC=2077|UniProtKB=Q9NWW5 Q9NWW5 CLN6 PTHR16244:SF2 CEROID-LIPOFUSCINOSIS NEURONAL PROTEIN 6 CEROID-LIPOFUSCINOSIS NEURONAL PROTEIN 6 early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endosome#GO:0005768;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;organelle lumen#GO:0043233;membrane raft#GO:0045121;membrane microdomain#GO:0098857;endoplasmic reticulum#GO:0005783;cytoplasm#GO:0005737;endomembrane system#GO:0012505;endoplasmic reticulum lumen#GO:0005788;membrane-enclosed lumen#GO:0031974;membrane#GO:0016020 HUMAN|HGNC=7461|UniProtKB=P03915 P03915 MT-ND5 PTHR42829:SF4 NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 5 NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 5 transport#GO:0006810;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;monoatomic cation transport#GO:0006812;proton transmembrane transport#GO:1902600;cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655 membrane protein complex#GO:0098796;membrane#GO:0016020;oxidoreductase complex#GO:1990204;respiratory chain complex#GO:0098803;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494;respiratory chain complex I#GO:0045271;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=5000|UniProtKB=P26583 P26583 HMGB2 PTHR48112:SF3 HIGH MOBILITY GROUP PROTEIN DSP1 HIGH MOBILITY GROUP PROTEIN B2 cellular component organization or biogenesis#GO:0071840;chromatin organization#GO:0006325;chromatin remodeling#GO:0006338;cellular component organization#GO:0016043;cellular process#GO:0009987 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;HMG box transcription factor#PC00024 HUMAN|HGNC=26837|UniProtKB=Q5JTC6 Q5JTC6 AMER1 PTHR22237:SF0 APC MEMBRANE RECRUITMENT PROTEIN 2-RELATED APC MEMBRANE RECRUITMENT PROTEIN 1 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;protein-membrane adaptor activity#GO:0043495 regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of Wnt signaling pathway#GO:0030111;regulation of cell communication#GO:0010646;regulation of canonical Wnt signaling pathway#GO:0060828;regulation of biological process#GO:0050789;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HUMAN|HGNC=17342|UniProtKB=Q6RI45 Q6RI45 BRWD3 PTHR16266:SF25 WD REPEAT DOMAIN 9 BROMODOMAIN AND WD REPEAT-CONTAINING PROTEIN 3 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=20127|UniProtKB=Q86SX3 Q86SX3 TEDC1 PTHR35076:SF1 TUBULIN EPSILON AND DELTA COMPLEX PROTEIN 1 TUBULIN EPSILON AND DELTA COMPLEX PROTEIN 1 HUMAN|HGNC=20120|UniProtKB=Q17RC7 Q17RC7 EXOC3L4 PTHR21292:SF14 EXOCYST COMPLEX COMPONENT SEC6-RELATED EXOCYST COMPLEX COMPONENT 3-LIKE PROTEIN 4 binding#GO:0005488;SNARE binding#GO:0000149;protein binding#GO:0005515 export from cell#GO:0140352;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;secretion by cell#GO:0032940;exocytosis#GO:0006887;secretion#GO:0046903;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810 cell cortex#GO:0005938;cell periphery#GO:0071944;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;exocyst#GO:0000145;cytoplasm#GO:0005737;vesicle tethering complex#GO:0099023;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HUMAN|HGNC=24640|UniProtKB=Q3B7T1 Q3B7T1 EDRF1 PTHR15000:SF1 ERYTHROID DIFFERENTIATION-RELATED FACTOR 1 ERYTHROID DIFFERENTIATION-RELATED FACTOR 1 regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 HUMAN|HGNC=7550|UniProtKB=Q14324 Q14324 MYBPC2 PTHR13817:SF17 TITIN MYOSIN-BINDING PROTEIN C, FAST-TYPE structural molecule activity#GO:0005198 cell differentiation#GO:0030154;actin cytoskeleton organization#GO:0030036;muscle structure development#GO:0061061;actomyosin structure organization#GO:0031032;cell development#GO:0048468;muscle cell development#GO:0055001;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;muscle cell differentiation#GO:0042692;myofibril assembly#GO:0030239;anatomical structure morphogenesis#GO:0009653;striated muscle cell development#GO:0055002;anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;organelle assembly#GO:0070925;animal gross anatomical part developmental process#GO:0160108;cellular component assembly involved in morphogenesis#GO:0010927;sarcomere organization#GO:0045214;actin filament-based process#GO:0030029;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;striated muscle cell differentiation#GO:0051146;anatomical structure formation involved in morphogenesis#GO:0048646;cellular anatomical entity morphogenesis#GO:0032989;developmental process#GO:0032502 M band#GO:0031430;intracellular organelle#GO:0043229;sarcomere#GO:0030017;membraneless organelle#GO:0043228;myofibril#GO:0030016;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;A band#GO:0031672;contractile muscle fiber#GO:0043292;supramolecular complex#GO:0099080;organelle#GO:0043226;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737 structural protein#PC00211 HUMAN|HGNC=3694|UniProtKB=P02679 P02679 FGG PTHR19143:SF338 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN GAMMA CHAIN regulation of biological quality#GO:0065008;wound healing#GO:0042060;protein activation cascade#GO:0072376;cell-substrate adhesion#GO:0031589;protein metabolic process#GO:0019538;cell adhesion#GO:0007155;cell-matrix adhesion#GO:0007160;blood coagulation, fibrin clot formation#GO:0072378;cell activation#GO:0001775;response to stimulus#GO:0050896;regulation of body fluid levels#GO:0050878;primary metabolic process#GO:0044238;hemostasis#GO:0007599;blood coagulation#GO:0007596;macromolecule metabolic process#GO:0043170;platelet activation#GO:0030168;platelet aggregation#GO:0070527;metabolic process#GO:0008152;biosynthetic process#GO:0009058;biological regulation#GO:0065007;homotypic cell-cell adhesion#GO:0034109;gene expression#GO:0010467;protein maturation#GO:0051604;multicellular organismal process#GO:0032501;coagulation#GO:0050817;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cell-cell adhesion#GO:0098609;response to wounding#GO:0009611;response to stress#GO:0006950 cellular anatomical structure#GO:0110165;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576 intercellular signal molecule#PC00207 Plasminogen activating cascade#P00050>Fibrin#P01253;Blood coagulation#P00011>Fibrin polymer cross-linked#P00443;Blood coagulation#P00011>Fibrinogen#P00406;Blood coagulation#P00011>Fibrin monomer#P00418 HUMAN|HGNC=19264|UniProtKB=Q8NBV8 Q8NBV8 SYT8 PTHR10024:SF249 SYNAPTOTAGMIN SYNAPTOTAGMIN-8 binding#GO:0005488;phospholipid binding#GO:0005543;SNARE binding#GO:0000149;protein binding#GO:0005515;molecular sensor activity#GO:0140299;molecular function regulator activity#GO:0098772;lipid binding#GO:0008289 modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;chemical synaptic transmission#GO:0007268;signal release from synapse#GO:0099643;regulation of exocytosis#GO:0017157;localization#GO:0051179;cell communication#GO:0007154;regulation of secretion#GO:0051046;secretion#GO:0046903;signal release#GO:0023061;trans-synaptic signaling#GO:0099537;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;neurotransmitter secretion#GO:0007269;positive regulation of cellular process#GO:0048522;establishment of localization#GO:0051234;synaptic vesicle cycle#GO:0099504;transport#GO:0006810;signaling#GO:0023052;export from cell#GO:0140352;regulation of synaptic vesicle exocytosis#GO:2000300;regulation of cellular component organization#GO:0051128;regulation of neurotransmitter secretion#GO:0046928;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;regulation of organelle organization#GO:0033043;secretion by cell#GO:0032940;regulation of secretion by cell#GO:1903530;cellular localization#GO:0051641;positive regulation of organelle organization#GO:0010638;positive regulation of cellular component organization#GO:0051130;regulation of signaling#GO:0023051;regulation of neurotransmitter transport#GO:0051588;neurotransmitter transport#GO:0006836;vesicle-mediated transport#GO:0016192;regulation of trans-synaptic signaling#GO:0099177;positive regulation of transport#GO:0051050;positive regulation of biological process#GO:0048518;establishment of localization in cell#GO:0051649;synaptic vesicle exocytosis#GO:0016079;cellular process#GO:0009987;synaptic signaling#GO:0099536;exocytosis#GO:0006887;regulation of localization#GO:0032879;positive regulation of vesicle fusion#GO:0031340;regulation of transport#GO:0051049;vesicle-mediated transport in synapse#GO:0099003;regulated exocytosis#GO:0045055 cell junction#GO:0030054;bounding membrane of organelle#GO:0098588;secretory vesicle#GO:0099503;presynapse#GO:0098793;neuron projection#GO:0043005;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;intracellular vesicle#GO:0097708;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;cell projection#GO:0042995;organelle membrane#GO:0031090;membrane#GO:0016020;vesicle membrane#GO:0012506;cell periphery#GO:0071944;transport vesicle membrane#GO:0030658;endomembrane system#GO:0012505;transport vesicle#GO:0030133;plasma membrane#GO:0005886;axon#GO:0030424;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;synaptic vesicle#GO:0008021;synaptic vesicle membrane#GO:0030672;vesicle#GO:0031982;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231 membrane trafficking regulatory protein#PC00151 Synaptic vesicle trafficking#P05734>Synaptotagmin#P05769 HUMAN|HGNC=5124|UniProtKB=P31275 P31275 HOXC12 PTHR46440:SF2 HOMEOBOX PROTEIN HOX-D12-RELATED HOMEOBOX PROTEIN HOX-C12 DNA binding#GO:0003677;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;double-stranded DNA binding#GO:0003690;binding#GO:0005488;nucleic acid binding#GO:0003676 homeodomain transcription factor#PC00119 HUMAN|HGNC=3332|UniProtKB=Q7KZI7 Q7KZI7 MARK2 PTHR24346:SF56 MAP/MICROTUBULE AFFINITY-REGULATING KINASE SERINE_THREONINE-PROTEIN KINASE MARK2 protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096 cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;intracellular signal transduction#GO:0035556;microtubule cytoskeleton organization#GO:0000226;cell communication#GO:0007154;cellular process#GO:0009987;signal transduction#GO:0007165;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=28670|UniProtKB=Q96C19 Q96C19 EFHD2 PTHR13025:SF2 EF-HAND DOMAIN-CONTAINING PROTEIN D EF-HAND DOMAIN-CONTAINING PROTEIN D2 calcium ion binding#GO:0005509;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;cation binding#GO:0043169;metal ion binding#GO:0046872 calmodulin-related#PC00061 HUMAN|HGNC=3149|UniProtKB=Q13011 Q13011 ECH1 PTHR43149:SF7 ENOYL-COA HYDRATASE DELTA(3,5)-DELTA(2,4)-DIENOYL-COA ISOMERASE, MITOCHONDRIAL intramolecular oxidoreductase activity#GO:0016860;isomerase activity#GO:0016853;catalytic activity#GO:0003824 lipid modification#GO:0030258;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;fatty acid beta-oxidation#GO:0006635;fatty acid oxidation#GO:0019395;monocarboxylic acid catabolic process#GO:0072329;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;lipid catabolic process#GO:0016042;lipid oxidation#GO:0034440;fatty acid catabolic process#GO:0009062;oxoacid metabolic process#GO:0043436;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;small molecule catabolic process#GO:0044282;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739 hydratase#PC00120 HUMAN|HGNC=3385|UniProtKB=P21709 P21709 EPHA1 PTHR24416:SF28 TYROSINE-PROTEIN KINASE RECEPTOR EPHRIN TYPE-A RECEPTOR 1 transmembrane signaling receptor activity#GO:0004888;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein tyrosine kinase activity#GO:0004714;molecular transducer activity#GO:0060089;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein tyrosine kinase activity#GO:0004713;signaling receptor activity#GO:0038023;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity, acting on a protein#GO:0140096 cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;signaling receptor complex#GO:0043235;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=11892|UniProtKB=P01375 P01375 TNF PTHR11471:SF23 TUMOR NECROSIS FACTOR FAMILY MEMBER TUMOR NECROSIS FACTOR molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;cytokine activity#GO:0005125 cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;response to chemical#GO:0042221;response to cytokine#GO:0034097;cell surface receptor signaling pathway#GO:0007166;regulation of apoptotic process#GO:0042981;extrinsic apoptotic signaling pathway via death domain receptors#GO:0008625;positive regulation of canonical NF-kappaB signal transduction#GO:0043123;positive regulation of apoptotic process#GO:0043065;regulation of programmed cell death#GO:0043067;apoptotic process#GO:0006915;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;positive regulation of programmed cell death#GO:0043068;response to stimulus#GO:0050896;extrinsic apoptotic signaling pathway#GO:0097191;signaling#GO:0023052;regulation of intracellular signal transduction#GO:1902531;immune system process#GO:0002376;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;response to peptide#GO:1901652;response to tumor necrosis factor#GO:0034612;regulation of canonical NF-kappaB signal transduction#GO:0043122;positive regulation of cellular process#GO:0048522;immune response#GO:0006955;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;apoptotic signaling pathway#GO:0097190;positive regulation of extrinsic apoptotic signaling pathway#GO:2001238;programmed cell death#GO:0012501;regulation of extrinsic apoptotic signaling pathway#GO:2001236;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;cell death#GO:0008219;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;positive regulation of apoptotic signaling pathway#GO:2001235;regulation of cell communication#GO:0010646;cytokine-mediated signaling pathway#GO:0019221;regulation of apoptotic signaling pathway#GO:2001233;tumor necrosis factor-mediated signaling pathway#GO:0033209;cell communication#GO:0007154 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 Wnt signaling pathway#P00057>NFAT Target Genes#G01559;Apoptosis signaling pathway#P00006>TNF#P00259 HUMAN|HGNC=24849|UniProtKB=Q6W3E5 Q6W3E5 GDPD4 PTHR23344:SF13 GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE 6 hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;phosphoric diester hydrolase activity#GO:0008081;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578 membrane#GO:0016020;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;phosphodiesterase#PC00185 HUMAN|HGNC=25056|UniProtKB=Q9Y2M5 Q9Y2M5 KLHL20 PTHR24412:SF508 KELCH PROTEIN KELCH-LIKE PROTEIN 20 ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 ubiquitin-dependent protein catabolic process#GO:0006511;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;Golgi vesicle transport#GO:0048193;transport#GO:0006810;macromolecule catabolic process#GO:0009057;intracellular transport#GO:0046907;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;proteasomal protein catabolic process#GO:0010498;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;post-Golgi vesicle-mediated transport#GO:0006892;cellular localization#GO:0051641;protein metabolic process#GO:0019538;localization#GO:0051179;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;cytosolic transport#GO:0016482;catabolic process#GO:0009056;Golgi to endosome transport#GO:0006895;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238 intracellular organelle lumen#GO:0070013;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ubiquitin ligase complex#GO:0000151;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;PML body#GO:0016605;cullin-RING ubiquitin ligase complex#GO:0031461;Golgi apparatus#GO:0005794;transferase complex#GO:1990234;membraneless organelle#GO:0043228;Cul3-RING ubiquitin ligase complex#GO:0031463;intracellular protein-containing complex#GO:0140535;membrane-enclosed lumen#GO:0031974;Golgi apparatus subcompartment#GO:0098791;nucleus#GO:0005634;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;trans-Golgi network#GO:0005802;nuclear body#GO:0016604;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232 scaffold/adaptor protein#PC00226 HUMAN|HGNC=32709|UniProtKB=A0A087WXS9 A0A087WXS9 TBC1D3I PTHR22957:SF571 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN TBC1 DOMAIN FAMILY MEMBER 3-RELATED enzyme activator activity#GO:0008047;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 GTPase-activating protein#PC00257;protein-binding activity modulator#PC00095;G-protein modulator#PC00022 HUMAN|HGNC=20473|UniProtKB=Q9BX63 Q9BX63 BRIP1 PTHR11472:SF47 DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER FANCONI ANEMIA GROUP J PROTEIN macromolecular conformation isomerase activity#GO:0120543;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;isomerase activity#GO:0016853;DNA helicase activity#GO:0003678;catalytic activity, acting on DNA#GO:0140097;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;ATP-dependent activity, acting on DNA#GO:0008094 macromolecule metabolic process#GO:0043170;meiotic nuclear division#GO:0140013;DNA repair#GO:0006281;DNA damage response#GO:0006974;nucleobase-containing compound metabolic process#GO:0006139;organelle fission#GO:0048285;meiosis I cell cycle process#GO:0061982;sexual reproduction#GO:0019953;reproductive process#GO:0022414;homologous recombination#GO:0035825;cell cycle#GO:0007049;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;reciprocal homologous recombination#GO:0140527;cellular response to stimulus#GO:0051716;cellular component organization or biogenesis#GO:0071840;double-strand break repair#GO:0006302;metabolic process#GO:0008152;meiotic cell cycle#GO:0051321;DNA metabolic process#GO:0006259;DNA recombination#GO:0006310;nucleotide-excision repair#GO:0006289;organelle organization#GO:0006996;response to stress#GO:0006950;cellular process#GO:0009987;nuclear division#GO:0000280;cellular response to stress#GO:0033554;reciprocal meiotic recombination#GO:0007131;response to stimulus#GO:0050896;meiosis I#GO:0007127;cellular component organization#GO:0016043;meiotic cell cycle process#GO:1903046;cell cycle process#GO:0022402 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA helicase#PC00011;DNA metabolism protein#PC00009 HUMAN|HGNC=17259|UniProtKB=Q9Y4Z0 Q9Y4Z0 LSM4 PTHR23338:SF16 SMALL NUCLEAR RIBONUCLEOPROTEIN SM U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM4 binding#GO:0005488;nucleic acid binding#GO:0003676;snRNA binding#GO:0017069;RNA binding#GO:0003723 macromolecule metabolic process#GO:0043170;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;macromolecule biosynthetic process#GO:0009059;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;protein-RNA complex assembly#GO:0022618;organelle assembly#GO:0070925;RNA splicing, via transesterification reactions#GO:0000375;RNA biosynthetic process#GO:0032774;spliceosomal snRNP assembly#GO:0000387;P-body assembly#GO:0033962;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;protein-RNA complex organization#GO:0071826;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA processing#GO:0006396;cellular component assembly#GO:0022607;gene expression#GO:0010467;cellular process#GO:0009987;mRNA processing#GO:0006397;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;mRNA metabolic process#GO:0016071;ribonucleoprotein complex biogenesis#GO:0022613;protein-containing complex assembly#GO:0065003;mRNA splicing, via spliceosome#GO:0000398;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;spliceosomal snRNP complex#GO:0097525;intracellular organelle#GO:0043229;spliceosomal tri-snRNP complex#GO:0097526;ribonucleoprotein complex#GO:1990904;P-body#GO:0000932;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;nucleus#GO:0005634;small nuclear ribonucleoprotein complex#GO:0030532;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;Sm-like protein family complex#GO:0120114;U6 snRNP#GO:0005688 RNA metabolism protein#PC00031;RNA splicing factor#PC00148;RNA processing factor#PC00147 HUMAN|HGNC=16862|UniProtKB=Q92565 Q92565 RAPGEF5 PTHR23113:SF26 GUANINE NUCLEOTIDE EXCHANGE FACTOR RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 5 molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;guanyl-nucleotide exchange factor activity#GO:0005085 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;small GTPase-mediated signal transduction#GO:0007264;intracellular signaling cassette#GO:0141124;Ras protein signal transduction#GO:0007265;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=3827|UniProtKB=P25090 P25090 FPR2 PTHR24225:SF0 CHEMOTACTIC RECEPTOR N-FORMYL PEPTIDE RECEPTOR 2 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653;immune receptor activity#GO:0140375;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528 immune response-activating signaling pathway#GO:0002757;regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166;positive regulation of immune response#GO:0050778;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;positive regulation of immune system process#GO:0002684;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;activation of immune response#GO:0002253;cell communication#GO:0007154;regulation of biological quality#GO:0065008;immune system process#GO:0002376;positive regulation of cytosolic calcium ion concentration#GO:0007204;G protein-coupled receptor signaling pathway#GO:0007186;phospholipase C-activating G protein-coupled receptor signaling pathway#GO:0007200;regulation of immune response#GO:0050776;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;response to stimulus#GO:0050896;immune response-activating cell surface receptor signaling pathway#GO:0002429;signaling#GO:0023052;cellular response to stimulus#GO:0051716;immune response-regulating signaling pathway#GO:0002764;regulation of biological process#GO:0050789 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CHKR#P00854 HUMAN|HGNC=30217|UniProtKB=Q9UNQ2 Q9UNQ2 DIMT1 PTHR11727:SF34 DIMETHYLADENOSINE TRANSFERASE DIMETHYLADENOSINE TRANSFERASE catalytic activity, acting on a rRNA#GO:0140102;rRNA (adenine) methyltransferase activity#GO:0016433;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;N-methyltransferase activity#GO:0008170;RNA methyltransferase activity#GO:0008173;catalytic activity, acting on RNA#GO:0140098;rRNA methyltransferase activity#GO:0008649;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a nucleic acid#GO:0140640 biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;rRNA methylation#GO:0031167;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;rRNA modification#GO:0000154;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;rRNA processing#GO:0006364;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;methylation#GO:0032259;RNA methylation#GO:0001510;macromolecule methylation#GO:0043414;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;ribosome biogenesis#GO:0042254 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634 RNA metabolism protein#PC00031;RNA methyltransferase#PC00033 HUMAN|HGNC=11250|UniProtKB=Q9Y5K1 Q9Y5K1 SPO11 PTHR10848:SF0 MEIOTIC RECOMBINATION PROTEIN SPO11 MEIOTIC RECOMBINATION PROTEIN SPO11 nucleic acid binding#GO:0003676;binding#GO:0005488;DNA binding#GO:0003677 cellular process#GO:0009987;meiotic DNA double-strand break formation#GO:0042138;response to stress#GO:0006950;organelle organization#GO:0006996;DNA recombination#GO:0006310;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;meiotic cell cycle#GO:0051321;double-strand break repair#GO:0006302;cellular component organization or biogenesis#GO:0071840;cell cycle process#GO:0022402;meiotic cell cycle process#GO:1903046;cellular component organization#GO:0016043;meiosis I#GO:0007127;response to stimulus#GO:0050896;reciprocal meiotic recombination#GO:0007131;cellular response to stress#GO:0033554;nuclear division#GO:0000280;nucleobase-containing compound metabolic process#GO:0006139;DNA damage response#GO:0006974;DNA repair#GO:0006281;meiotic nuclear division#GO:0140013;DNA double-strand break processing#GO:0000729;macromolecule metabolic process#GO:0043170;cellular response to stimulus#GO:0051716;reciprocal homologous recombination#GO:0140527;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cell cycle#GO:0007049;reproductive process#GO:0022414;homologous recombination#GO:0035825;sexual reproduction#GO:0019953;meiosis I cell cycle process#GO:0061982;organelle fission#GO:0048285 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;chromosome#GO:0005694;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;intracellular membrane-bounded organelle#GO:0043231 endodeoxyribonuclease#PC00093 HUMAN|HGNC=4414|UniProtKB=P22749 P22749 GNLY PTHR15541:SF2 GRANULYSIN RELATED GRANULYSIN response to bacterium#GO:0009617;immune system process#GO:0002376;defense response to bacterium#GO:0042742;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;response to stimulus#GO:0050896;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;antimicrobial humoral response#GO:0019730;cell killing#GO:0001906;humoral immune response#GO:0006959;response to external stimulus#GO:0009605;defense response#GO:0006952;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;immune response#GO:0006955;defense response to symbiont#GO:0140546;cellular process#GO:0009987;defense response to other organism#GO:0098542;response to other organism#GO:0051707 lysosome#GO:0005764;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;vacuole#GO:0005773;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;lytic vacuole#GO:0000323 HUMAN|HGNC=17376|UniProtKB=Q9UIJ7 Q9UIJ7 AK3 PTHR23359:SF68 NUCLEOTIDE KINASE GTP:AMP PHOSPHOTRANSFERASE AK3, MITOCHONDRIAL kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;nucleobase-containing compound kinase activity#GO:0019205;catalytic activity#GO:0003824;transferase activity#GO:0016740;phosphotransferase activity, phosphate group as acceptor#GO:0016776 nucleoside triphosphate metabolic process#GO:0009141;nucleoside phosphate metabolic process#GO:0006753;purine ribonucleoside monophosphate metabolic process#GO:0009167;nucleoside monophosphate metabolic process#GO:0009123;small molecule metabolic process#GO:0044281;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;nucleotide metabolic process#GO:0009117;ribonucleotide metabolic process#GO:0009259;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;carbohydrate derivative metabolic process#GO:1901135;nucleoside triphosphate biosynthetic process#GO:0009142;organophosphate metabolic process#GO:0019637;purine nucleoside monophosphate metabolic process#GO:0009126;nucleobase-containing small molecule metabolic process#GO:0055086;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;intracellular organelle lumen#GO:0070013 nucleotide kinase#PC00172;kinase#PC00137 De novo purine biosynthesis#P02738>Adenylate kinase#P02896 HUMAN|HGNC=18099|UniProtKB=Q8N690 Q8N690 DEFB119 PTHR47902:SF1 BETA-DEFENSIN 119 BETA-DEFENSIN 119 antimicrobial response protein#PC00051;defense/immunity protein#PC00090 HUMAN|HGNC=10567|UniProtKB=Q9GZW5 Q9GZW5 SCAND2P PTHR45935:SF26 PROTEIN ZBED8-RELATED SCAN DOMAIN-CONTAINING PROTEIN SCAND2P-RELATED HUMAN|HGNC=26013|UniProtKB=Q86Y56 Q86Y56 DNAAF5 PTHR16216:SF11 DYNEIN ASSEMBLY FACTOR 5, AXONEMAL DYNEIN AXONEMAL ASSEMBLY FACTOR 5 binding#GO:0005488;protein binding#GO:0005515 plasma membrane bounded cell projection assembly#GO:0120031;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;protein-containing complex organization#GO:0043933;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cell projection assembly#GO:0030031;cellular process#GO:0009987;outer dynein arm assembly#GO:0036158;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection organization#GO:0120036;organelle assembly#GO:0070925;inner dynein arm assembly#GO:0036159;axonemal dynein complex assembly#GO:0070286;microtubule bundle formation#GO:0001578;microtubule cytoskeleton organization#GO:0000226;axoneme assembly#GO:0035082;cilium organization#GO:0044782;cellular component organization#GO:0016043;cilium assembly#GO:0060271;protein-containing complex assembly#GO:0065003;cell projection organization#GO:0030030 intracellular organelle#GO:0043229;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membraneless organelle#GO:0043228 chaperone#PC00072 HUMAN|HGNC=29629|UniProtKB=P41223 P41223 BUD31 PTHR19411:SF0 PROTEIN BUD31-RELATED PROTEIN BUD31 HOMOLOG RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058 spliceosomal complex#GO:0005681;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA processing factor#PC00147 HUMAN|HGNC=19086|UniProtKB=Q96DB2 Q96DB2 HDAC11 PTHR10625:SF23 HISTONE DEACETYLASE HDAC1-RELATED HISTONE DEACETYLASE 11 deacylase activity#GO:0160215;histone deacetylase activity#GO:0004407;catalytic activity#GO:0003824;histone modifying activity#GO:0140993;deacetylase activity#GO:0019213;catalytic activity, acting on a protein#GO:0140096 cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;chromatin organization#GO:0006325;biological regulation#GO:0065007;chromatin remodeling#GO:0006338;regulation of metabolic process#GO:0019222;epigenetic regulation of gene expression#GO:0040029;cellular component organization#GO:0016043;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;cellular process#GO:0009987 nuclear protein-containing complex#GO:0140513;protein-containing complex#GO:0032991;membrane-enclosed lumen#GO:0031974;histone deacetylase complex#GO:0000118;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233 HUMAN|HGNC=15225|UniProtKB=Q8NGK5 Q8NGK5 OR52M1 PTHR26450:SF136 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 52M1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=20162|UniProtKB=Q9H972 Q9H972 C14orf93 PTHR14375:SF2 SIMILAR TO RIKEN CDNA 4931414P19 SIMILAR TO HUMAN CHROMOSOME 14 OPEN READING FRAME 93 HUMAN|HGNC=11178|UniProtKB=O75908 O75908 SOAT2 PTHR10408:SF10 STEROL O-ACYLTRANSFERASE STEROL O-ACYLTRANSFERASE 2 alcohol binding#GO:0043178;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;steroid binding#GO:0005496;heterocyclic compound binding#GO:1901363;catalytic activity#GO:0003824;transferase activity#GO:0016740;cholesterol binding#GO:0015485;lipid binding#GO:0008289;small molecule binding#GO:0036094;anion binding#GO:0043168;binding#GO:0005488;sterol binding#GO:0032934;nucleoside phosphate binding#GO:1901265;acyltransferase activity#GO:0016746;ion binding#GO:0043167 lipid localization#GO:0010876;organic hydroxy compound transport#GO:0015850;localization#GO:0051179;primary metabolic process#GO:0044238;secondary alcohol metabolic process#GO:1902652;small molecule metabolic process#GO:0044281;transport#GO:0006810;cholesterol metabolic process#GO:0008203;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;alcohol metabolic process#GO:0006066;establishment of localization#GO:0051234;sterol transport#GO:0015918;sterol metabolic process#GO:0016125;cellular process#GO:0009987;cholesterol efflux#GO:0033344;macromolecule localization#GO:0033036;cholesterol transport#GO:0030301;steroid metabolic process#GO:0008202;lipid transport#GO:0006869 organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020 acyltransferase#PC00042;transferase#PC00220 Androgen/estrogene/progesterone biosynthesis#P02727>Cholesterol acyltransferase#P02829 HUMAN|HGNC=26925|UniProtKB=Q6PCB6 Q6PCB6 ABHD17C PTHR12277:SF55 ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN ALPHA_BETA HYDROLASE DOMAIN-CONTAINING PROTEIN 17C thiolester hydrolase activity#GO:0016790;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;palmitoyl hydrolase activity#GO:0098599 regulation of protein localization#GO:0032880;regulation of localization#GO:0032879;regulation of biological quality#GO:0065008;regulation of synapse structure or activity#GO:0050803;regulation of synapse organization#GO:0050807;biological regulation#GO:0065007;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789;regulation of postsynapse organization#GO:0099175;negative regulation of biological process#GO:0048519 vesicle membrane#GO:0012506;membrane#GO:0016020;cell periphery#GO:0071944;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;plasma membrane#GO:0005886;cytoplasm#GO:0005737;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;endosome membrane#GO:0010008;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410 serine protease#PC00203 HUMAN|HGNC=3230|UniProtKB=Q9NYQ7 Q9NYQ7 CELSR3 PTHR24026:SF38 FAT ATYPICAL CADHERIN-RELATED CADHERIN EGF LAG SEVEN-PASS G-TYPE RECEPTOR 3 plasma membrane bounded cell projection organization#GO:0120036;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;multicellular organismal process#GO:0032501;cellular process#GO:0009987;cell-cell adhesion#GO:0098609;axon development#GO:0061564;neuron projection development#GO:0031175;neurogenesis#GO:0022008;cell projection morphogenesis#GO:0048858;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;neuron differentiation#GO:0030182;cell development#GO:0048468;cell morphogenesis#GO:0000902;cell differentiation#GO:0030154;cell projection organization#GO:0030030;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;neuron development#GO:0048666;axonogenesis#GO:0007409;system development#GO:0048731;anatomical structure development#GO:0048856;cell adhesion#GO:0007155;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108 cell-cell junction#GO:0005911;cell junction#GO:0030054;cellular anatomical structure#GO:0110165;adherens junction#GO:0005912;anchoring junction#GO:0070161 cadherin#PC00057 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HUMAN|HGNC=2744|UniProtKB=Q9NR30 Q9NR30 DDX21 PTHR47958:SF109 ATP-DEPENDENT RNA HELICASE DBP3 NUCLEOLAR RNA HELICASE 2 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;ATP-dependent activity#GO:0140657;helicase activity#GO:0004386;catalytic activity, acting on RNA#GO:0140098;isomerase activity#GO:0016853;catalytic activity#GO:0003824;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;RNA helicase activity#GO:0003724;macromolecular conformation isomerase activity#GO:0120543 intracellular organelle#GO:0043229;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981 RNA helicase#PC00032 HUMAN|HGNC=14139|UniProtKB=P0CG20 P0CG20 PRR35 PTHR14678:SF2 PROLINE-RICH PROTEIN 35-RELATED PROLINE-RICH PROTEIN 35 HUMAN|HGNC=18454|UniProtKB=P58294 P58294 PROK1 PTHR18821:SF7 PROKINETICIN PROKINETICIN-1 epithelial cell proliferation#GO:0050673;endothelial cell proliferation#GO:0001935;cellular process#GO:0009987;cell population proliferation#GO:0008283 peptide hormone#PC00179 HUMAN|HGNC=3588|UniProtKB=O15287 O15287 FANCG PTHR15254:SF2 FANCONI ANEMIA GROUP G PROTEIN FAMILY MEMBER FANCONI ANEMIA GROUP G PROTEIN cellular response to stimulus#GO:0051716;cellular process#GO:0009987;DNA damage response#GO:0006974;cellular response to stress#GO:0033554;response to stress#GO:0006950;response to stimulus#GO:0050896 nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Fanconi anaemia nuclear complex#GO:0043240;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 HUMAN|HGNC=21083|UniProtKB=Q9BWJ5 Q9BWJ5 SF3B5 PTHR20978:SF0 SPLICING FACTOR 3B SUBUNIT 5 SPLICING FACTOR 3B SUBUNIT 5 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;spliceosomal snRNP complex#GO:0097525;intracellular organelle#GO:0043229;precatalytic spliceosome#GO:0071011;ribonucleoprotein complex#GO:1990904;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513;U2 snRNP#GO:0005686;protein-containing complex#GO:0032991;nucleus#GO:0005634;small nuclear ribonucleoprotein complex#GO:0030532 RNA metabolism protein#PC00031;RNA splicing factor#PC00148;RNA processing factor#PC00147 HUMAN|HGNC=4192|UniProtKB=P47871 P47871 GCGR PTHR45620:SF29 PDF RECEPTOR-LIKE PROTEIN-RELATED GLUCAGON RECEPTOR signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;molecular transducer activity#GO:0060089;G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=10591|UniProtKB=P35499 P35499 SCN4A PTHR10037:SF223 VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM SODIUM CHANNEL PROTEIN TYPE 4 SUBUNIT ALPHA passive transmembrane transporter activity#GO:0022803;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;sodium channel activity#GO:0005272;monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;voltage-gated sodium channel activity#GO:0005248;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267 transport#GO:0006810;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;system process#GO:0003008;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;multicellular organismal process#GO:0032501;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transmembrane transport#GO:0098655;nervous system process#GO:0050877;sensory perception#GO:0007600;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;sensory perception of pain#GO:0019233;sodium ion transport#GO:0006814;action potential#GO:0001508;metal ion transport#GO:0030001;membrane depolarization#GO:0051899 cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;sodium channel complex#GO:0034706;transmembrane transporter complex#GO:1902495;axon#GO:0030424;plasma membrane#GO:0005886;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020;transporter complex#GO:1990351;cation channel complex#GO:0034703 voltage-gated ion channel#PC00241 HUMAN|HGNC=30103|UniProtKB=Q14CZ0 Q14CZ0 HAPSTR1 PTHR31624:SF3 UPF0472 PROTEIN C16ORF72 HUWE1-ASSOCIATED PROTEIN MODIFYING STRESS RESPONSES 1 HUMAN|HGNC=18327|UniProtKB=P61236 P61236 YPEL3 PTHR13848:SF102 PROTEIN YIPPEE-LIKE CG15309-RELATED PROTEIN YIPPEE-LIKE 3 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=4205|UniProtKB=O95395 O95395 GCNT3 PTHR19297:SF81 GLYCOSYLTRANSFERASE 14 FAMILY MEMBER BETA-1,3-GALACTOSYL-O-GLYCOSYL-GLYCOPROTEIN BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE 3 catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;acetylglucosaminyltransferase activity#GO:0008375 glycosyltransferase#PC00111 HUMAN|HGNC=44652|UniProtKB=H3BQW9 H3BQW9 FAM229A PTHR35355:SF1 PROTEIN FAM229A PROTEIN FAM229A HUMAN|HGNC=21053|UniProtKB=Q5TF39 Q5TF39 SLC60A2 PTHR23121:SF9 SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1 SOLUTE CARRIER FAMILY 60 MEMBER 2 transporter#PC00227 HUMAN|HGNC=554|UniProtKB=Q10567 Q10567 AP1B1 PTHR11134:SF31 ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER AP-1 COMPLEX SUBUNIT BETA-1 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;receptor-mediated endocytosis#GO:0006898;import into cell#GO:0098657;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810 cellular anatomical structure#GO:0110165;clathrin coat#GO:0030118;organelle#GO:0043226;coated vesicle membrane#GO:0030662;Golgi-associated vesicle membrane#GO:0030660;intracellular vesicle#GO:0097708;coated membrane#GO:0048475;coated vesicle#GO:0030135;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;vesicle coat#GO:0030120;clathrin-coated vesicle membrane#GO:0030665;bounding membrane of organelle#GO:0098588;AP-type membrane coat adaptor complex#GO:0030119;clathrin vesicle coat#GO:0030125;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;vesicle#GO:0031982;membrane coat#GO:0030117;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;trans-Golgi network transport vesicle#GO:0030140;AP-1 adaptor complex#GO:0030121;transport vesicle membrane#GO:0030658;endomembrane system#GO:0012505;transport vesicle#GO:0030133;membrane#GO:0016020;vesicle membrane#GO:0012506;organelle membrane#GO:0031090;clathrin-coated vesicle#GO:0030136;trans-Golgi network transport vesicle membrane#GO:0012510;Golgi apparatus#GO:0005794;Golgi-associated vesicle#GO:0005798 membrane traffic protein#PC00150 HUMAN|HGNC=29789|UniProtKB=Q9ULD2 Q9ULD2 MTUS1 PTHR24200:SF7 TOUCAN, ISOFORM A MICROTUBULE-ASSOCIATED TUMOR SUPPRESSOR 1 cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;microtubule binding#GO:0008017;binding#GO:0005488;protein binding#GO:0005515 regulation of cell motility#GO:2000145;regulation of cell migration#GO:0030334;regulation of response to stimulus#GO:0048583;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;regulation of leukocyte migration#GO:0002685;regulation of response to external stimulus#GO:0032101;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of chemotaxis#GO:0050920 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 HUMAN|HGNC=13059|UniProtKB=Q14584 Q14584 ZNF266 PTHR24381:SF149 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 266 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=25438|UniProtKB=Q86YV5 Q86YV5 PRAG1 PTHR22972:SF3 SERINE/THREONINE PROTEIN KINASE INACTIVE TYROSINE-PROTEIN KINASE PRAG1 protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824 regulation of biological process#GO:0050789;regulation of cell motility#GO:2000145;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of locomotion#GO:0040012 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=11371|UniProtKB=Q9NUL3 Q9NUL3 STAU2 PTHR46054:SF1 MATERNAL EFFECT PROTEIN STAUFEN DOUBLE-STRANDED RNA-BINDING PROTEIN STAUFEN HOMOLOG 2 RNA binding#GO:0003723;double-stranded RNA binding#GO:0003725;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729 cellular process involved in reproduction in multicellular organism#GO:0022412;reproductive process#GO:0022414;cell development#GO:0048468;RNA localization#GO:0006403;gamete generation#GO:0007276;microtubule-based movement#GO:0007018;cell differentiation#GO:0030154;germ cell development#GO:0007281;developmental process involved in reproduction#GO:0003006;multicellular organismal reproductive process#GO:0048609;anatomical structure development#GO:0048856;cellular localization#GO:0051641;localization#GO:0051179;sexual reproduction#GO:0019953;microtubule-based transport#GO:0099111;protein localization to cell junction#GO:1902414;cytoskeleton-dependent intracellular transport#GO:0030705;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;axo-dendritic transport#GO:0008088;macromolecule localization#GO:0033036;microtubule-based process#GO:0007017;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;cellular developmental process#GO:0048869;protein localization to synapse#GO:0035418;transport#GO:0006810;developmental process#GO:0032502;intracellular transport#GO:0046907 cell body#GO:0044297;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;neuronal cell body#GO:0043025;cell projection#GO:0042995;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;membraneless organelle#GO:0043228;cytoplasmic stress granule#GO:0010494 HUMAN|HGNC=24789|UniProtKB=Q6ZSJ8 Q6ZSJ8 C1orf122 PTHR41401:SF1 RGD1559909 SIMILAR TO HUMAN CHROMOSOME 1 OPEN READING FRAME 122 HUMAN|HGNC=9555|UniProtKB=O75832 O75832 PSMD10 PTHR24126:SF24 ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 10 HUMAN|HGNC=2343|UniProtKB=P82279 P82279 CRB1 PTHR24049:SF1 CRUMBS FAMILY MEMBER PROTEIN CRUMBS HOMOLOG 1 establishment or maintenance of epithelial cell apical/basal polarity#GO:0045197;establishment or maintenance of bipolar cell polarity#GO:0061245;cell adhesion#GO:0007155;establishment or maintenance of apical/basal cell polarity#GO:0035088;establishment or maintenance of cell polarity#GO:0007163;heterophilic cell-cell adhesion#GO:0007157;cellular process#GO:0009987;cell-cell adhesion#GO:0098609 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 cell adhesion molecule#PC00069 HUMAN|HGNC=16920|UniProtKB=Q99828 Q99828 CIB1 PTHR45791:SF3 CALCIUM AND INTEGRIN BINDING FAMILY MEMBER 2 CALCIUM AND INTEGRIN-BINDING PROTEIN 1 calcium ion binding#GO:0005509;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;magnesium ion binding#GO:0000287;cation binding#GO:0043169;metal ion binding#GO:0046872 HUMAN|HGNC=10442|UniProtKB=P46781 P46781 RPS9 PTHR11831:SF48 30S 40S RIBOSOMAL PROTEIN SMALL RIBOSOMAL SUBUNIT PROTEIN US4 nucleic acid binding#GO:0003676;binding#GO:0005488;structural constituent of ribosome#GO:0003735;rRNA binding#GO:0019843;RNA binding#GO:0003723;structural molecule activity#GO:0005198 cellular component biogenesis#GO:0044085;ribosome biogenesis#GO:0042254;ribosomal small subunit biogenesis#GO:0042274;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;ribonucleoprotein complex biogenesis#GO:0022613 ribonucleoprotein complex#GO:1990904;cytosolic small ribosomal subunit#GO:0022627;intracellular organelle#GO:0043229;small ribosomal subunit#GO:0015935;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;cytosolic ribosome#GO:0022626;ribosome#GO:0005840;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737 translational protein#PC00263;ribosomal protein#PC00202 HUMAN|HGNC=26876|UniProtKB=Q460N3 Q460N3 PARP15 PTHR14453:SF99 PARP/ZINC FINGER CCCH TYPE DOMAIN CONTAINING PROTEIN PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP15 transcription regulator activity#GO:0140110;pentosyltransferase activity#GO:0016763;NAD+ poly-ADP-ribosyltransferase activity#GO:0003950;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;transcription corepressor activity#GO:0003714;transferase activity#GO:0016740;transcription coregulator activity#GO:0003712 regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;negative regulation of metabolic process#GO:0009892;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=235|UniProtKB=Q8NFM4 Q8NFM4 ADCY4 PTHR45627:SF10 ADENYLATE CYCLASE TYPE 1 ADENYLATE CYCLASE TYPE 4 catalytic activity#GO:0003824;phosphorus-oxygen lyase activity#GO:0016849;cyclase activity#GO:0009975;lyase activity#GO:0016829;adenylate cyclase activity#GO:0004016 ribonucleotide metabolic process#GO:0009259;G protein-coupled receptor signaling pathway#GO:0007186;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;cyclic nucleotide biosynthetic process#GO:0009190;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;nucleotide biosynthetic process#GO:0009165;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521;regulation of biological process#GO:0050789;purine nucleotide metabolic process#GO:0006163;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;signaling#GO:0023052;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing compound biosynthetic process#GO:0034654;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;metabolic process#GO:0008152;cyclic purine nucleotide metabolic process#GO:0052652;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;ribose phosphate biosynthetic process#GO:0046390;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;signal transduction#GO:0007165;organophosphate biosynthetic process#GO:0090407;cell communication#GO:0007154;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;nucleoside phosphate metabolic process#GO:0006753;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cyclic nucleotide metabolic process#GO:0009187;nucleoside phosphate biosynthetic process#GO:1901293;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;carbohydrate derivative metabolic process#GO:1901135;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;biosynthetic process#GO:0009058 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 adenylate cyclase#PC00043 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>cAMP cyclase#P00719;Endothelin signaling pathway#P00019>Adenylate cyclase#P00569;GABA-B receptor II signaling#P05731>AC#P05760 HUMAN|HGNC=15581|UniProtKB=Q7Z6R9 Q7Z6R9 TFAP2D PTHR10812:SF5 TRANSCRIPTION FACTOR AP-2 TRANSCRIPTION FACTOR AP-2-DELTA sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;DNA-binding transcription activator activity#GO:0001216;transcription cis-regulatory region binding#GO:0000976 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;regulation of cell population proliferation#GO:0042127;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 RNA metabolism protein#PC00031;general transcription factor#PC00259 HUMAN|HGNC=7583|UniProtKB=P10916 P10916 MYL2 PTHR23049:SF9 MYOSIN REGULATORY LIGHT CHAIN 2 MYOSIN REGULATORY LIGHT CHAIN 2, VENTRICULAR_CARDIAC MUSCLE ISOFORM ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;calcium ion binding#GO:0005509;protein binding#GO:0005515;metal ion binding#GO:0046872;cation binding#GO:0043169;myosin binding#GO:0017022;cytoskeletal protein binding#GO:0008092 system process#GO:0003008;heart contraction#GO:0060047;cellular developmental process#GO:0048869;animal organ development#GO:0048513;multicellular organism development#GO:0007275;cell fate specification#GO:0001708;muscle contraction#GO:0006936;developmental process#GO:0032502;multicellular organismal process#GO:0032501;heart development#GO:0007507;blood circulation#GO:0008015;cellular process#GO:0009987;system development#GO:0048731;cell fate commitment#GO:0045165;anatomical structure development#GO:0048856;cardiac muscle contraction#GO:0060048;circulatory system process#GO:0003013;animal gross anatomical part developmental process#GO:0160108;striated muscle contraction#GO:0006941;muscle structure development#GO:0061061;cell differentiation#GO:0030154;circulatory system development#GO:0072359;heart process#GO:0003015;muscle cell differentiation#GO:0042692;muscle system process#GO:0003012 myosin complex#GO:0016459;contractile muscle fiber#GO:0043292;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;actin cytoskeleton#GO:0015629;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;myofibril#GO:0030016;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512 actin or actin-binding cytoskeletal protein#PC00041;cytoskeletal protein#PC00085 HUMAN|HGNC=3011|UniProtKB=Q07507 Q07507 DPT PTHR15040:SF2 DERMATOPONTIN-RELATED DERMATOPONTIN structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;collagen fibril organization#GO:0030199;extracellular matrix organization#GO:0030198;external encapsulating structure organization#GO:0045229;extracellular structure organization#GO:0043062;cell adhesion#GO:0007155 cell adhesion molecule#PC00069 HUMAN|HGNC=2264|UniProtKB=Q14061 Q14061 COX17 PTHR16719:SF0 CYTOCHROME C OXIDASE COPPER CHAPERONE CYTOCHROME C OXIDASE COPPER CHAPERONE molecular carrier activity#GO:0140104 cytochrome complex assembly#GO:0017004;mitochondrial respiratory chain complex IV assembly#GO:0033617;respiratory chain complex IV assembly#GO:0008535;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;mitochondrion organization#GO:0007005;mitochondrial respiratory chain complex assembly#GO:0033108;cellular component assembly#GO:0022607 mitochondrial envelope#GO:0005740;mitochondrion#GO:0005739;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;mitochondrial intermembrane space#GO:0005758;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 chaperone#PC00072 HUMAN|HGNC=7672|UniProtKB=O75376 O75376 NCOR1 PTHR13992:SF5 NUCLEAR RECEPTOR CO-REPRESSOR RELATED NCOR NUCLEAR RECEPTOR COREPRESSOR 1 transcription corepressor activity#GO:0003714;transcription factor binding#GO:0008134;nuclear receptor binding#GO:0016922;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;binding#GO:0005488;DNA-binding transcription factor binding#GO:0140297;RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629;protein binding#GO:0005515 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;chromatin#GO:0000785;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165 chromatin/chromatin-binding, or -regulatory protein#PC00077 Huntington disease#P00029>N-CoR#P00770 HUMAN|HGNC=5008|UniProtKB=P54868 P54868 HMGCS2 PTHR43323:SF1 3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE HYDROXYMETHYLGLUTARYL-COA SYNTHASE, MITOCHONDRIAL acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740 metabolic process#GO:0008152;acetyl-CoA metabolic process#GO:0006084;acyl-CoA metabolic process#GO:0006637;nucleobase-containing small molecule metabolic process#GO:0055086;organophosphate metabolic process#GO:0019637;primary metabolic process#GO:0044238;sulfur compound metabolic process#GO:0006790;phosphorus metabolic process#GO:0006793;cellular process#GO:0009987;purine-containing compound metabolic process#GO:0072521;small molecule metabolic process#GO:0044281;nucleobase-containing compound metabolic process#GO:0006139;nucleoside phosphate metabolic process#GO:0006753 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=20480|UniProtKB=Q96PP9 Q96PP9 GBP4 PTHR10751:SF142 GUANYLATE BINDING PROTEIN GUANYLATE-BINDING PROTEIN 4 pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708 G-protein#PC00020;heterotrimeric G-protein#PC00117 HUMAN|HGNC=9721|UniProtKB=P32322 P32322 PYCR1 PTHR11645:SF6 PYRROLINE-5-CARBOXYLATE REDUCTASE PYRROLINE-5-CARBOXYLATE REDUCTASE 1, MITOCHONDRIAL oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 amino acid biosynthetic process#GO:0008652;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;small molecule biosynthetic process#GO:0044283;proteinogenic amino acid biosynthetic process#GO:0170038;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;cellular process#GO:0009987;carboxylic acid biosynthetic process#GO:0046394;proteinogenic amino acid metabolic process#GO:0170039;small molecule metabolic process#GO:0044281;amino acid metabolic process#GO:0006520;biosynthetic process#GO:0009058 metabolite interconversion enzyme#PC00262;reductase#PC00198 Proline biosynthesis#P02768>Pyrroline-5-carboxylate reductase#P03113 HUMAN|HGNC=6925|UniProtKB=P02686 P02686 MBP PTHR11429:SF0 MYELIN BASIC PROTEIN MYELIN BASIC PROTEIN cellular process#GO:0009987;cellular component organization#GO:0016043;nervous system development#GO:0007399;membrane organization#GO:0061024;multicellular organismal process#GO:0032501;developmental process#GO:0032502;animal gross anatomical part developmental process#GO:0160108;myelination#GO:0042552;system development#GO:0048731;anatomical structure development#GO:0048856;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840 axon#GO:0030424;neuron projection#GO:0043005;cell body#GO:0044297;main axon#GO:0044304;cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;neuronal cell body#GO:0043025;myelin sheath#GO:0043209;cell projection#GO:0042995;somatodendritic compartment#GO:0036477 myelin protein#PC00161;structural protein#PC00211 HUMAN|HGNC=10377|UniProtKB=P05387 P05387 RPLP2 PTHR21141:SF120 60S ACIDIC RIBOSOMAL PROTEIN FAMILY MEMBER LARGE RIBOSOMAL SUBUNIT PROTEIN P2 ribosomal protein#PC00202 HUMAN|HGNC=8781|UniProtKB=Q07343 Q07343 PDE4B PTHR11347:SF108 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 3',5'-CYCLIC-AMP PHOSPHODIESTERASE 4B catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578;cyclic-nucleotide phosphodiesterase activity#GO:0004112 regulation of intracellular signal transduction#GO:1902531;negative regulation of cellular process#GO:0048523;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;negative regulation of response to stimulus#GO:0048585;regulation of cell communication#GO:0010646;negative regulation of signal transduction#GO:0009968;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966 hydrolase#PC00121;phosphodiesterase#PC00185 HUMAN|HGNC=30304|UniProtKB=Q6ZS82 Q6ZS82 RGS9BP PTHR21029:SF1 R-SEVEN BINDING PROTEIN (R7BP) HOMOLOG REGULATOR OF G PROTEIN SIGNALING 9-BINDING PROTEIN multicellular organismal process#GO:0032501;biological regulation#GO:0065007;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;signal transduction#GO:0007165;response to radiation#GO:0009314;cellular process#GO:0009987;response to external stimulus#GO:0009605;system process#GO:0003008;response to light stimulus#GO:0009416;visual perception#GO:0007601;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;sensory perception of light stimulus#GO:0050953;response to abiotic stimulus#GO:0009628;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;sensory perception#GO:0007600;nervous system process#GO:0050877 neuron projection#GO:0043005;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025 HUMAN|HGNC=7750|UniProtKB=Q92832 Q92832 NELL1 PTHR24042:SF2 NEL HOMOLOG PROTEIN KINASE C-BINDING PROTEIN NELL1 carbohydrate derivative binding#GO:0097367;heparin binding#GO:0008201;protein binding#GO:0005515;binding#GO:0005488;kinase binding#GO:0019900;glycosaminoglycan binding#GO:0005539;enzyme binding#GO:0019899;protein kinase binding#GO:0019901 positive regulation of multicellular organismal process#GO:0051240;positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of multicellular organismal process#GO:0051239;regulation of developmental process#GO:0050793;biological regulation#GO:0065007;regulation of cell differentiation#GO:0045595 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 calcium-binding protein#PC00060 HUMAN|HGNC=10663|UniProtKB=O60524 O60524 NEMF PTHR15239:SF6 NUCLEAR EXPORT MEDIATOR FACTOR NEMF RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF ribosomal large subunit binding#GO:0043023;RNA binding#GO:0003723;ribonucleoprotein complex binding#GO:0043021;tRNA binding#GO:0000049;ribosome binding#GO:0043022;protein-containing complex binding#GO:0044877;nucleic acid binding#GO:0003676;binding#GO:0005488 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;organelle organization#GO:0006996;proteasomal protein catabolic process#GO:0010498;biosynthetic process#GO:0009058;gene expression#GO:0010467;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;translational elongation#GO:0006414;ubiquitin-dependent protein catabolic process#GO:0006511;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;rescue of stalled cytosolic ribosome#GO:0072344;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;protein biosynthetic process#GO:0160307;catabolic process#GO:0009056;cytoplasmic translation#GO:0002181;translation#GO:0006412;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;cellular component disassembly#GO:0022411;protein metabolic process#GO:0019538;organelle disassembly#GO:1903008 protein-containing complex#GO:0032991 HUMAN|HGNC=30988|UniProtKB=Q6ZN30 Q6ZN30 BNC2 PTHR15021:SF2 DISCONNECTED-RELATED ZINC FINGER PROTEIN BASONUCLIN-2 regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=31990|UniProtKB=Q3BBV2 Q3BBV2 NBPF8 PTHR14199:SF35 NEUROBLASTOMA BREAKPOINT FAMILY MEMBER 6-LIKE PROTEIN NBPF FAMILY MEMBER NBPF1-RELATED HUMAN|HGNC=19233|UniProtKB=Q495W5 Q495W5 POFUT4 PTHR11929:SF198 ALPHA- 1,3 -FUCOSYLTRANSFERASE GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 4 catalytic activity#GO:0003824;transferase activity#GO:0016740;fucosyltransferase activity#GO:0008417;hexosyltransferase activity#GO:0016758;glycosyltransferase activity#GO:0016757;alpha-(1->3)-fucosyltransferase activity#GO:0046920 glycosyltransferase#PC00111 HUMAN|HGNC=29673|UniProtKB=Q13361 Q13361 MFAP5 PTHR16485:SF6 MICROFIBRILLAR-ASSOCIATED PROTEIN 2 MICROFIBRILLAR-ASSOCIATED PROTEIN 5 anatomical structure development#GO:0048856;eye development#GO:0001654;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;embryonic organ development#GO:0048568;animal organ morphogenesis#GO:0009887;sensory organ morphogenesis#GO:0090596;visual system development#GO:0150063;anatomical structure morphogenesis#GO:0009653;animal organ development#GO:0048513;multicellular organism development#GO:0007275;embryonic morphogenesis#GO:0048598;sensory organ development#GO:0007423;developmental process#GO:0032502;multicellular organismal process#GO:0032501;embryo development#GO:0009790;sensory system development#GO:0048880 extracellular region#GO:0005576;supramolecular fiber#GO:0099512;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;interstitial matrix#GO:0005614;supramolecular complex#GO:0099080;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081 HUMAN|HGNC=26895|UniProtKB=Q3KP31 Q3KP31 ZNF791 PTHR24379:SF106 KRAB AND ZINC FINGER DOMAIN-CONTAINING ZINC FINGER PROTEIN 791 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218;C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HUMAN|HGNC=4659|UniProtKB=P78347 P78347 GTF2I PTHR46304:SF2 GENERAL TRANSCRIPTION FACTOR II-I REPEAT DOMAIN-CONTAINING PROTEIN 1 GENERAL TRANSCRIPTION FACTOR II-I DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 general transcription factor#PC00259;RNA metabolism protein#PC00031 HUMAN|HGNC=4102|UniProtKB=Q13069 Q13069 GAGE5 PTHR14047:SF30 P ANTIGEN FAMILY MEMBER 5-RELATED G ANTIGEN 1-RELATED HUMAN|HGNC=31951|UniProtKB=Q7Z692 Q7Z692 CEACAM19 PTHR44337:SF6 CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 8 CELL ADHESION MOLECULE CEACAM19 cell-cell adhesion#GO:0098609;homophilic cell-cell adhesion#GO:0007156;cellular process#GO:0009987;heterophilic cell-cell adhesion#GO:0007157;cell adhesion#GO:0007155 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 cell adhesion molecule#PC00069;immunoglobulin superfamily cell adhesion molecule#PC00125 HUMAN|HGNC=2176|UniProtKB=Q9UQ52 Q9UQ52 CNTN6 PTHR10075:SF45 BASIGIN RELATED CONTACTIN-6 cell adhesion molecule#PC00069 HUMAN|HGNC=4808|UniProtKB=P61296 P61296 HAND2 PTHR23349:SF41 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST HEART- AND NEURAL CREST DERIVATIVES-EXPRESSED PROTEIN 2 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;circulatory system development#GO:0072359;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;heart development#GO:0007507;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biosynthetic process#GO:0009889;animal organ development#GO:0048513;multicellular organism development#GO:0007275;regulation of gene expression#GO:0010468;developmental process#GO:0032502 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 basic helix-loop-helix transcription factor#PC00055;DNA-binding transcription factor#PC00218 HUMAN|HGNC=29344|UniProtKB=Q9UFD9 Q9UFD9 RIMBP3 PTHR14234:SF21 RIM BINDING PROTEIN-RELATED RIMS-BINDING PROTEIN 3A-RELATED signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515 gamete generation#GO:0007276;cell differentiation#GO:0030154;cellular process involved in reproduction in multicellular organism#GO:0022412;cell development#GO:0048468;reproductive process#GO:0022414;fertilization#GO:0009566;developmental process involved in reproduction#GO:0003006;germ cell development#GO:0007281;anatomical structure development#GO:0048856;multicellular organismal reproductive process#GO:0048609;spermatid differentiation#GO:0048515;spermatid development#GO:0007286;sexual reproduction#GO:0019953;male gamete generation#GO:0048232;cellular process#GO:0009987;cellular developmental process#GO:0048869;spermatogenesis#GO:0007283;developmental process#GO:0032502 intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;microtubule cytoskeleton#GO:0015630;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 scaffold/adaptor protein#PC00226 HUMAN|HGNC=974|UniProtKB=O75363 O75363 BCAS1 PTHR15016:SF6 BREAST CARCINOMA-AMPLIFIED SEQUENCE 1 BREAST CARCINOMA-AMPLIFIED SEQUENCE 1 animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502;multicellular organism development#GO:0007275;anatomical structure development#GO:0048856;system development#GO:0048731;myelination#GO:0042552;cellular process#GO:0009987;multicellular organismal process#GO:0032501;nervous system development#GO:0007399 HUMAN|HGNC=8579|UniProtKB=Q99487 Q99487 PAFAH2 PTHR10272:SF6 PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE 2, CYTOPLASMIC hydrolase activity#GO:0016787;catalytic activity#GO:0003824;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788 protein modifying enzyme#PC00260 HUMAN|HGNC=5256|UniProtKB=Q14568 Q14568 HSP90AA2P PTHR11528:SF131 HEAT SHOCK PROTEIN 90 FAMILY MEMBER HEAT SHOCK PROTEIN HSP 90-ALPHA A2-RELATED hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;ATP-dependent activity#GO:0140657;nucleoside phosphate binding#GO:1901265;ATP binding#GO:0005524;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;ATP hydrolysis activity#GO:0016887;hydrolase activity#GO:0016787 protein folding#GO:0006457;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;response to abiotic stimulus#GO:0009628;primary metabolic process#GO:0044238;regulation of biological quality#GO:0065008;protein metabolic process#GO:0019538;cellular response to stress#GO:0033554;response to temperature stimulus#GO:0009266;biological regulation#GO:0065007;biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;regulation of protein stability#GO:0031647;response to stress#GO:0006950;cellular response to heat#GO:0034605;response to heat#GO:0009408;protein stabilization#GO:0050821;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152 cytosol#GO:0005829;membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;perinuclear region of cytoplasm#GO:0048471;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 chaperone#PC00072;Hsp90 family chaperone#PC00028 HUMAN|HGNC=28977|UniProtKB=P53990 P53990 IST1 PTHR12161:SF56 IST1 FAMILY MEMBER IST1 HOMOLOG intracellular protein localization#GO:0008104;localization#GO:0051179;macromolecule localization#GO:0033036 HUMAN|HGNC=11760|UniProtKB=P10646 P10646 TFPI PTHR10083:SF328 KUNITZ-TYPE PROTEASE INHIBITOR-RELATED TISSUE FACTOR PATHWAY INHIBITOR molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866;enzyme inhibitor activity#GO:0004857;molecular function inhibitor activity#GO:0140678;serine-type endopeptidase inhibitor activity#GO:0004867;enzyme regulator activity#GO:0030234;peptidase regulator activity#GO:0061134;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protein-binding activity modulator#PC00095;protease inhibitor#PC00191 Blood coagulation#P00011>TFPI#P00417 HUMAN|HGNC=9620|UniProtKB=Q12792 Q12792 TWF1 PTHR13759:SF8 TWINFILIN TWINFILIN-1 protein-containing complex binding#GO:0044877;protein binding#GO:0005515;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;actin filament binding#GO:0051015;actin monomer binding#GO:0003785;binding#GO:0005488 negative regulation of organelle organization#GO:0010639;negative regulation of cellular component organization#GO:0051129;regulation of supramolecular fiber organization#GO:1902903;regulation of protein polymerization#GO:0032271;negative regulation of supramolecular fiber organization#GO:1902904;regulation of cytoskeleton organization#GO:0051493;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;protein-containing complex disassembly#GO:0032984;regulation of actin filament depolymerization#GO:0030834;negative regulation of protein polymerization#GO:0032272;actin filament capping#GO:0051693;actin filament-based process#GO:0030029;negative regulation of cytoskeleton organization#GO:0051494;negative regulation of protein-containing complex disassembly#GO:0043242;negative regulation of protein-containing complex assembly#GO:0031333;supramolecular fiber organization#GO:0097435;regulation of cell projection assembly#GO:0060491;actin polymerization or depolymerization#GO:0008154;regulation of actin filament organization#GO:0110053;regulation of actin filament polymerization#GO:0030833;biological regulation#GO:0065007;regulation of actin polymerization or depolymerization#GO:0008064;negative regulation of protein depolymerization#GO:1901880;protein depolymerization#GO:0051261;regulation of cell projection organization#GO:0031344;negative regulation of cellular process#GO:0048523;regulation of actin filament-based process#GO:0032970;regulation of plasma membrane bounded cell projection organization#GO:0120035;actin filament organization#GO:0007015;regulation of protein depolymerization#GO:1901879;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;regulation of protein-containing complex assembly#GO:0043254;regulation of cellular component size#GO:0032535;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;regulation of cellular component organization#GO:0051128;regulation of plasma membrane bounded cell projection assembly#GO:0120032;negative regulation of actin filament polymerization#GO:0030837;regulation of cellular component biogenesis#GO:0044087;regulation of actin filament length#GO:0030832;cellular component disassembly#GO:0022411;regulation of biological quality#GO:0065008;negative regulation of actin filament depolymerization#GO:0030835;organelle organization#GO:0006996;regulation of protein-containing complex disassembly#GO:0043244;actin filament depolymerization#GO:0030042;cellular process#GO:0009987;cytoskeleton organization#GO:0007010;regulation of actin cytoskeleton organization#GO:0032956;regulation of anatomical structure size#GO:0090066;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933 intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;contractile muscle fiber#GO:0043292;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;actin filament#GO:0005884;cytoskeleton#GO:0005856;organelle#GO:0043226;cellular anatomical structure#GO:0110165;actin cytoskeleton#GO:0015629;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;myofibril#GO:0030016;intracellular organelle#GO:0043229 non-motor actin binding protein#PC00165 HUMAN|HGNC=26541|UniProtKB=Q8IYT1 Q8IYT1 GARIN4 PTHR22574:SF15 FAMILY NOT NAMED GOLGI-ASSOCIATED RAB2 INTERACTOR PROTEIN 4 HUMAN|HGNC=17329|UniProtKB=Q9H6Q3 Q9H6Q3 SLA2 PTHR10155:SF6 PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT SRC-LIKE-ADAPTER 2 enzyme regulator activity#GO:0030234;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772 response to chemical#GO:0042221;cellular response to nitrogen compound#GO:1901699;biological regulation#GO:0065007;response to peptide hormone#GO:0043434;response to hormone#GO:0009725;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987;cellular response to insulin stimulus#GO:0032869;cell surface receptor signaling pathway#GO:0007166;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;cellular response to hormone stimulus#GO:0032870;regulation of cellular process#GO:0050794;signaling#GO:0023052;cellular response to peptide hormone stimulus#GO:0071375;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to insulin#GO:0032868;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;response to nitrogen compound#GO:1901698;cellular response to chemical stimulus#GO:0070887;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;insulin receptor signaling pathway#GO:0008286;response to oxygen-containing compound#GO:1901700 membrane#GO:0016020;membrane protein complex#GO:0098796;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;transferase complex#GO:1990234;extrinsic component of membrane#GO:0019898 kinase modulator#PC00140 Interleukin signaling pathway#P00036>Src-like#P00991 HUMAN|HGNC=8601|UniProtKB=Q06141 Q06141 REG3A PTHR22803:SF123 MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED REGENERATING ISLET-DERIVED PROTEIN 3-ALPHA signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;growth factor activity#GO:0008083;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;hormone activity#GO:0005179 response to oxygen-containing compound#GO:1901700;immune system process#GO:0002376;response to nitrogen compound#GO:1901698;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;regulation of cell population proliferation#GO:0042127;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;positive regulation of cell population proliferation#GO:0008284;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;humoral immune response#GO:0006959;antimicrobial humoral response#GO:0019730;defense response#GO:0006952;response to external stimulus#GO:0009605;defense response to symbiont#GO:0140546;positive regulation of biological process#GO:0048518;immune response#GO:0006955;positive regulation of cellular process#GO:0048522;response to hormone#GO:0009725;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;response to peptide hormone#GO:0043434;response to other organism#GO:0051707;biological regulation#GO:0065007;defense response to other organism#GO:0098542;response to chemical#GO:0042221 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=16144|UniProtKB=Q8NC74 Q8NC74 RBBP8NL PTHR15107:SF3 RETINOBLASTOMA BINDING PROTEIN 8 RBBP8 N-TERMINAL-LIKE PROTEIN DNA binding#GO:0003677;damaged DNA binding#GO:0003684;binding#GO:0005488;nucleic acid binding#GO:0003676 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular response to stimulus#GO:0051716;double-strand break repair via single-strand annealing#GO:0045002;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;response to stress#GO:0006950;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;DNA damage response#GO:0006974;DNA double-strand break processing#GO:0000729;macromolecule metabolic process#GO:0043170;double-strand break repair#GO:0006302 transcription cofactor#PC00217 HUMAN|HGNC=5109|UniProtKB=P31269 P31269 HOXA9 PTHR45970:SF3 AGAP004664-PA HOMEOBOX PROTEIN HOX-A9 double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 chordate embryonic development#GO:0043009;animal gross anatomical part developmental process#GO:0160108;skeletal system development#GO:0001501;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;anterior/posterior pattern specification#GO:0009952;embryonic morphogenesis#GO:0048598;multicellular organism development#GO:0007275;animal organ development#GO:0048513;embryo development#GO:0009790;pattern specification process#GO:0007389;embryonic organ development#GO:0048568;embryo development ending in birth or egg hatching#GO:0009792;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;animal organ morphogenesis#GO:0009887;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;skeletal system morphogenesis#GO:0048705;regulation of nucleobase-containing compound metabolic process#GO:0019219;regionalization#GO:0003002;multicellular organismal process#GO:0032501;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119 HUMAN|HGNC=2488|UniProtKB=P52952 P52952 NKX2-5 PTHR24340:SF28 HOMEOBOX PROTEIN NKX HOMEOBOX PROTEIN NKX-2.5 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;regulation of biological process#GO:0050789;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=11649|UniProtKB=O95988 O95988 TCL1B PTHR14060:SF2 PROTEIN P13 MTCP-1 T-CELL LEUKEMIA_LYMPHOMA PROTEIN 1B kinase activator activity#GO:0019209;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;protein kinase activator activity#GO:0030295;enzyme activator activity#GO:0008047;protein serine/threonine kinase activator activity#GO:0043539;protein kinase regulator activity#GO:0019887;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 HUMAN|HGNC=2713|UniProtKB=O75935 O75935 DCTN3 PTHR28360:SF1 DYNACTIN SUBUNIT 3 DYNACTIN SUBUNIT 3 cytoskeleton-dependent cytokinesis#GO:0061640;cellular process#GO:0009987;cell cycle process#GO:0022402;cell division#GO:0051301;cell cycle#GO:0007049;cytokinesis#GO:0000910 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;actin cytoskeleton#GO:0015629;microtubule cytoskeleton#GO:0015630 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=830|UniProtKB=P06576 P06576 ATP5F1B PTHR15184:SF88 ATP SYNTHASE ATP SYNTHASE F(1) COMPLEX SUBUNIT BETA, MITOCHONDRIAL monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic cation channel activity#GO:0005261;proton channel activity#GO:0015252;passive transmembrane transporter activity#GO:0022803;proton transmembrane transporter activity#GO:0015078;catalytic activity#GO:0003824;ligase activity#GO:0016874;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;proton-transporting ATP synthase activity, rotational mechanism#GO:0046933;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267 nucleobase-containing small molecule metabolic process#GO:0055086;ribonucleoside triphosphate biosynthetic process#GO:0009201;carbohydrate derivative biosynthetic process#GO:1901137;ATP biosynthetic process#GO:0006754;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;cellular process#GO:0009987;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;ribose phosphate biosynthetic process#GO:0046390;nucleotide biosynthetic process#GO:0009165;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;ribonucleotide metabolic process#GO:0009259;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;small molecule metabolic process#GO:0044281;purine-containing compound metabolic process#GO:0072521;proton motive force-driven mitochondrial ATP synthesis#GO:0042776;purine nucleotide metabolic process#GO:0006163;phosphorus metabolic process#GO:0006793;energy derivation by oxidation of organic compounds#GO:0015980;nucleoside phosphate biosynthetic process#GO:1901293;generation of precursor metabolites and energy#GO:0006091;purine ribonucleoside triphosphate biosynthetic process#GO:0009206;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;purine ribonucleoside triphosphate metabolic process#GO:0009205;carbohydrate derivative metabolic process#GO:1901135;nucleoside triphosphate biosynthetic process#GO:0009142;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;aerobic respiration#GO:0009060;cellular respiration#GO:0045333;organophosphate biosynthetic process#GO:0090407;oxidative phosphorylation#GO:0006119;nucleoside triphosphate metabolic process#GO:0009141;nucleoside phosphate metabolic process#GO:0006753;proton motive force-driven ATP synthesis#GO:0015986;purine nucleoside triphosphate biosynthetic process#GO:0009145;purine nucleoside triphosphate metabolic process#GO:0009144;primary metabolic process#GO:0044238 transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;cation channel complex#GO:0034703;catalytic complex#GO:1902494;proton-transporting two-sector ATPase complex#GO:0016469;proton-transporting ATP synthase complex#GO:0045259;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;respiratory chain complex#GO:0098803;membrane protein complex#GO:0098796;membrane#GO:0016020 ATP synthase#PC00002 ATP synthesis#P02721>F1 beta#P02794 HUMAN|HGNC=16731|UniProtKB=Q969P5 Q969P5 FBXO32 PTHR13123:SF6 LD30288P F-BOX ONLY PROTEIN 32 protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;cellular process#GO:0009987;protein modification process#GO:0036211;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152 organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cullin-RING ubiquitin ligase complex#GO:0031461;SCF ubiquitin ligase complex#GO:0019005;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634;ubiquitin ligase complex#GO:0000151;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;intracellular organelle#GO:0043229;catalytic complex#GO:1902494 HUMAN|HGNC=24049|UniProtKB=Q96L15 Q96L15 ART5 PTHR10339:SF2 ADP-RIBOSYLTRANSFERASE ECTO-ADP-RIBOSYLTRANSFERASE 5 NAD+ poly-ADP-ribosyltransferase activity#GO:0003950;catalytic activity#GO:0003824;transferase activity#GO:0016740;pentosyltransferase activity#GO:0016763;glycosyltransferase activity#GO:0016757 transferase#PC00220 HUMAN|HGNC=4917|UniProtKB=Q9BW71 Q9BW71 HIRIP3 PTHR15410:SF2 HIRA-INTERACTING PROTEIN 3 HIRA-INTERACTING PROTEIN 3 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=10645|UniProtKB=P47992 P47992 XCL1 PTHR12015:SF101 SMALL INDUCIBLE CYTOKINE A CYTOKINE SCM-1 BETA-RELATED chemokine receptor binding#GO:0042379;protein binding#GO:0005515;molecular function activator activity#GO:0140677;signaling receptor binding#GO:0005102;cytokine receptor binding#GO:0005126;binding#GO:0005488;cytokine activity#GO:0005125;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;G protein-coupled receptor binding#GO:0001664;chemokine activity#GO:0008009 regulation of cell migration#GO:0030334;leukocyte migration#GO:0050900;positive regulation of locomotion#GO:0040017;myeloid leukocyte migration#GO:0097529;response to external stimulus#GO:0009605;leukocyte chemotaxis#GO:0030595;defense response#GO:0006952;positive regulation of cellular process#GO:0048522;immune response#GO:0006955;positive regulation of cell migration#GO:0030335;biological regulation#GO:0065007;response to other organism#GO:0051707;regulation of locomotion#GO:0040012;cell migration#GO:0016477;inflammatory response#GO:0006954;chemotaxis#GO:0006935;cytokine-mediated signaling pathway#GO:0019221;cell chemotaxis#GO:0060326;cell communication#GO:0007154;regulation of cell motility#GO:2000145;chemokine-mediated signaling pathway#GO:0070098;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;cellular response to stimulus#GO:0051716;response to external biotic stimulus#GO:0043207;locomotion#GO:0040011;cellular response to chemokine#GO:1990869;cell motility#GO:0048870;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;humoral immune response#GO:0006959;antimicrobial humoral response#GO:0019730;signal transduction#GO:0007165;defense response to symbiont#GO:0140546;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;response to biotic stimulus#GO:0009607;response to chemokine#GO:1990868;response to stress#GO:0006950;response to chemical#GO:0042221;response to cytokine#GO:0034097;taxis#GO:0042330;granulocyte migration#GO:0097530;defense response to other organism#GO:0098542;immune system process#GO:0002376;G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887;response to peptide#GO:1901652;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;positive regulation of cell motility#GO:2000147;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;granulocyte chemotaxis#GO:0071621;response to stimulus#GO:0050896 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 cytokine#PC00083 HUMAN|HGNC=15946|UniProtKB=Q8IWN7 Q8IWN7 RP1L1 PTHR23005:SF3 RETINITIS PIGMENTOSA 1 PROTEIN RETINITIS PIGMENTOSA 1-LIKE 1 PROTEIN cellular component assembly#GO:0022607;anatomical structure homeostasis#GO:0060249;cytoskeleton organization#GO:0007010;nervous system development#GO:0007399;retina development in camera-type eye#GO:0060041;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;sensory system development#GO:0048880;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;animal organ development#GO:0048513;microtubule-based process#GO:0007017;neuron differentiation#GO:0030182;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell development#GO:0048468;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cilium organization#GO:0044782;neuron development#GO:0048666;eye development#GO:0001654;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;cellular developmental process#GO:0048869;multicellular organismal-level homeostasis#GO:0048871;neurogenesis#GO:0022008;sensory organ development#GO:0007423;plasma membrane bounded cell projection assembly#GO:0120031;developmental process#GO:0032502;homeostatic process#GO:0042592;visual system development#GO:0150063;retina homeostasis#GO:0001895;microtubule cytoskeleton organization#GO:0000226;anatomical structure development#GO:0048856;tissue homeostasis#GO:0001894;system development#GO:0048731;axoneme assembly#GO:0035082;organelle assembly#GO:0070925;camera-type eye development#GO:0043010;microtubule bundle formation#GO:0001578 cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;ciliary transition zone#GO:0035869;cilium#GO:0005929;intracellular organelle#GO:0043229;axoneme#GO:0005930;non-motile cilium#GO:0097730;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;9+0 non-motile cilium#GO:0097731;photoreceptor cell cilium#GO:0097733;neuron projection#GO:0043005;ciliary plasm#GO:0097014;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228 HUMAN|HGNC=6645|UniProtKB=O43900 O43900 PRICKLE3 PTHR24211:SF19 LIM DOMAIN-CONTAINING PROTEIN PRICKLE PLANAR CELL POLARITY PROTEIN 3 cell periphery#GO:0071944;mitochondrion#GO:0005739;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 scaffold/adaptor protein#PC00226 HUMAN|HGNC=29017|UniProtKB=Q9Y4G2 Q9Y4G2 PLEKHM1 PTHR12326:SF5 PLECKSTRIN HOMOLOGY DOMAIN CONTAINING PROTEIN PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY M MEMBER 1 HUMAN|HGNC=18563|UniProtKB=Q9HBJ7 Q9HBJ7 USP29 PTHR24006:SF711 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 29 deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787;cysteine-type deubiquitinase activity#GO:0004843;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity, acting on a protein#GO:0140096 G1/S transition of mitotic cell cycle#GO:0000082;mitotic cell cycle phase transition#GO:0044772;regulation of biological quality#GO:0065008;mitotic cell cycle process#GO:1903047;cell cycle#GO:0007049;cellular process#GO:0009987;cell cycle process#GO:0022402;regulation of protein stability#GO:0031647;cell cycle G1/S phase transition#GO:0044843;cell cycle phase transition#GO:0044770;mitotic cell cycle#GO:0000278;biological regulation#GO:0065007 nucleus#GO:0005634;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 protease#PC00190;cysteine protease#PC00081 HUMAN|HGNC=3154|UniProtKB=O94769 O94769 ECM2 PTHR46544:SF1 EXTRACELLULAR MATRIX PROTEIN 2-RELATED EXTRACELLULAR MATRIX PROTEIN 2 protein-containing complex binding#GO:0044877;heparin binding#GO:0008201;binding#GO:0005488;carbohydrate derivative binding#GO:0097367;glycosaminoglycan binding#GO:0005539;collagen binding#GO:0005518 extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;positive regulation of cell adhesion#GO:0045785;positive regulation of cell-substrate adhesion#GO:0010811;regulation of biological process#GO:0050789;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular component organization#GO:0016043;regulation of cell-substrate adhesion#GO:0010810;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of cell adhesion#GO:0030155 external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=30493|UniProtKB=Q8TF30 Q8TF30 WHAMM PTHR23330:SF6 P300 TRANSCRIPTIONAL COFACTOR JMY-RELATED WASP HOMOLOG-ASSOCIATED PROTEIN WITH ACTIN, MEMBRANES AND MICROTUBULES protein-containing complex binding#GO:0044877;binding#GO:0005488 actin nucleation#GO:0045010;actin cytoskeleton organization#GO:0030036;cellular component organization#GO:0016043;cellular localization#GO:0051641;localization#GO:0051179;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;supramolecular fiber organization#GO:0097435;actin filament-based process#GO:0030029;vesicle-mediated transport#GO:0016192;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;Arp2/3 complex-mediated actin nucleation#GO:0034314;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;actin filament organization#GO:0007015;intracellular transport#GO:0046907;transport#GO:0006810;Golgi vesicle transport#GO:0048193 membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;membrane#GO:0016020 HUMAN|HGNC=30240|UniProtKB=Q8WVK2 Q8WVK2 SNRNP27 PTHR31077:SF2 U4/U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN U4_U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN nucleus#GO:0005634;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;precatalytic spliceosome#GO:0071011;ribonucleoprotein complex#GO:1990904;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513 HUMAN|HGNC=28276|UniProtKB=Q6UX53 Q6UX53 TMT1B PTHR45036:SF6 METHYLTRANSFERASE LIKE 7B THIOL S-METHYLTRANSFERASE TMT1B catalytic activity#GO:0003824;transferase activity#GO:0016740;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;transferase activity, transferring one-carbon groups#GO:0016741 transferase#PC00220;methyltransferase#PC00155;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=29093|UniProtKB=O75152 O75152 ZC3H11A PTHR15725:SF2 ZN-FINGER, C-X8-C-X5-C-X3-H TYPE-CONTAINING ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 11A mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 nucleocytoplasmic transport#GO:0006913;nuclear transport#GO:0051169;nuclear export#GO:0051168;localization#GO:0051179;mRNA export from nucleus#GO:0006406;nucleic acid transport#GO:0050657;cellular localization#GO:0051641;mRNA transport#GO:0051028;establishment of RNA localization#GO:0051236;nucleobase-containing compound transport#GO:0015931;RNA localization#GO:0006403;RNA transport#GO:0050658;transport#GO:0006810;metabolic process#GO:0008152;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;macromolecule metabolic process#GO:0043170;poly(A)+ mRNA export from nucleus#GO:0016973;establishment of localization#GO:0051234;establishment of localization in cell#GO:0051649;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule localization#GO:0033036;nitrogen compound transport#GO:0071705;biosynthetic process#GO:0009058;gene expression#GO:0010467 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 RNA processing factor#PC00147 HUMAN|HGNC=26968|UniProtKB=Q96CX6 Q96CX6 LRRC58 PTHR45752:SF13 LEUCINE-RICH REPEAT-CONTAINING LEUCINE-RICH REPEAT-CONTAINING PROTEIN 58 signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 scaffold/adaptor protein#PC00226 HUMAN|HGNC=27222|UniProtKB=Q6ZMS7 Q6ZMS7 ZNF783 PTHR23232:SF118 KRAB DOMAIN C2H2 ZINC FINGER ZINC FINGER PROTEIN 746-RELATED DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulator activity#GO:0140110;DNA-binding transcription repressor activity#GO:0001217;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565 regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=6301|UniProtKB=Q9ULS6 Q9ULS6 KCNS2 PTHR11537:SF60 VOLTAGE-GATED POTASSIUM CHANNEL DELAYED-RECTIFIER POTASSIUM CHANNEL REGULATORY SUBUNIT KCNS2 molecular function regulator activity#GO:0098772;channel regulator activity#GO:0016247;transporter regulator activity#GO:0141108;potassium channel regulator activity#GO:0015459;ion channel regulator activity#GO:0099106 cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;biological regulation#GO:0065007;potassium ion transport#GO:0006813;transport#GO:0006810;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;action potential#GO:0001508;metal ion transport#GO:0030001;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812 cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703 voltage-gated ion channel#PC00241;ion channel#PC00133 HUMAN|HGNC=25006|UniProtKB=Q9NRN9 Q9NRN9 METTL5 PTHR23290:SF0 RRNA N6-ADENOSINE-METHYLTRANSFERASE METTL5 RRNA N(6)-ADENOSINE-METHYLTRANSFERASE METTL5 catalytic activity, acting on a rRNA#GO:0140102;rRNA (adenine) methyltransferase activity#GO:0016433;N-methyltransferase activity#GO:0008170;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;rRNA methyltransferase activity#GO:0008649;catalytic activity, acting on RNA#GO:0140098;RNA methyltransferase activity#GO:0008173;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a nucleic acid#GO:0140640 RNA modification#GO:0009451;macromolecule methylation#GO:0043414;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;RNA methylation#GO:0001510;methylation#GO:0032259;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;rRNA modification#GO:0000154;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;rRNA methylation#GO:0031167;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467 HUMAN|HGNC=33911|UniProtKB=Q6P5S7 Q6P5S7 RNASEK PTHR31733:SF1 RIBONUCLEASE KAPPA RIBONUCLEASE KAPPA cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;transport#GO:0006810;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;proton transmembrane transport#GO:1902600;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811 membrane protein complex#GO:0098796;cation-transporting ATPase complex#GO:0090533;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;vacuolar proton-transporting V-type ATPase complex#GO:0016471;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ATPase complex#GO:1904949;transmembrane transporter complex#GO:1902495;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ATPase dependent transmembrane transport complex#GO:0098533;membrane#GO:0016020;protein-containing complex#GO:0032991;vacuole#GO:0005773;cytoplasm#GO:0005737;proton-transporting two-sector ATPase complex#GO:0016469;vacuolar membrane#GO:0005774;transporter complex#GO:1990351;proton-transporting V-type ATPase complex#GO:0033176;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090 endoribonuclease#PC00094 HUMAN|HGNC=2890|UniProtKB=O60832 O60832 DKC1 PTHR23127:SF0 CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5 H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT DKC1 isomerase activity#GO:0016853;intramolecular transferase activity#GO:0016866;catalytic activity#GO:0003824 RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;snRNA metabolic process#GO:0016073;macromolecule modification#GO:0043412;rRNA modification#GO:0000154;pseudouridine synthesis#GO:0001522;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA modification#GO:0016556;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;snRNA processing#GO:0016180;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;gene expression#GO:0010467 nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;sno(s)RNA-containing ribonucleoprotein complex#GO:0005732;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233 chromatin/chromatin-binding, or -regulatory protein#PC00077;centromere DNA-binding protein#PC00071 HUMAN|HGNC=11935|UniProtKB=P29965 P29965 CD40LG PTHR11471:SF5 TUMOR NECROSIS FACTOR FAMILY MEMBER CD40 LIGAND molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677;receptor ligand activity#GO:0048018;cytokine activity#GO:0005125;signaling receptor regulator activity#GO:0030545 regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of extrinsic apoptotic signaling pathway#GO:2001238;regulation of canonical NF-kappaB signal transduction#GO:0043122;positive regulation of cellular process#GO:0048522;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of response to stimulus#GO:0048584;regulation of apoptotic signaling pathway#GO:2001233;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of extrinsic apoptotic signaling pathway#GO:2001236;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;positive regulation of apoptotic signaling pathway#GO:2001235;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of apoptotic process#GO:0042981;cell surface receptor signaling pathway#GO:0007166;positive regulation of canonical NF-kappaB signal transduction#GO:0043123;positive regulation of apoptotic process#GO:0043065;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;positive regulation of signaling#GO:0023056;regulation of biological process#GO:0050789;regulation of programmed cell death#GO:0043067;signaling#GO:0023052;positive regulation of programmed cell death#GO:0043068;response to stimulus#GO:0050896 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HUMAN|HGNC=360|UniProtKB=O43918 O43918 AIRE PTHR47025:SF30 AUTOIMMUNE REGULATOR AUTOIMMUNE REGULATOR sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;histone binding#GO:0042393;protein binding#GO:0005515;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;chromatin binding#GO:0003682 regulation of cell migration#GO:0030334;regulation of biosynthetic process#GO:0009889;immune response#GO:0006955;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of locomotion#GO:0040012;biological regulation#GO:0065007;positive regulation of DNA-templated transcription#GO:0045893;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;epithelium development#GO:0060429;regulation of RNA metabolic process#GO:0051252;anatomical structure development#GO:0048856;positive regulation of RNA metabolic process#GO:0051254;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;multicellular organism development#GO:0007275;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604;lymphocyte activation#GO:0046649;animal gross anatomical part developmental process#GO:0160108;immune system process#GO:0002376;lymphocyte mediated immunity#GO:0002449;positive regulation of macromolecule biosynthetic process#GO:0010557;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cell development#GO:0048468;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;developmental process#GO:0032502;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of macromolecule biosynthetic process#GO:0010556;adaptive immune response#GO:0002250;regulation of RNA biosynthetic process#GO:2001141;hemopoiesis#GO:0030097;positive regulation of RNA biosynthetic process#GO:1902680;tissue development#GO:0009888;cell activation#GO:0001775;T cell mediated immunity#GO:0002456;lymphocyte differentiation#GO:0030098;regulation of lymphocyte migration#GO:2000401;system development#GO:0048731;regulation of DNA-templated transcription#GO:0006355;regulation of cell motility#GO:2000145;positive regulation of biosynthetic process#GO:0009891;tissue morphogenesis#GO:0048729;leukocyte activation#GO:0045321;regulation of leukocyte migration#GO:0002685;immune effector process#GO:0002252;humoral immune response#GO:0006959;positive regulation of transcription by RNA polymerase II#GO:0045944;morphogenesis of an epithelium#GO:0002009;animal organ development#GO:0048513;T cell differentiation#GO:0030217;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immune system development#GO:0002520;leukocyte mediated immunity#GO:0002443;positive regulation of metabolic process#GO:0009893;mononuclear cell differentiation#GO:1903131;leukocyte differentiation#GO:0002521;T cell activation#GO:0042110;cell differentiation#GO:0030154 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=674|UniProtKB=P98171 P98171 ARHGAP4 PTHR14166:SF16 SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN RHO GTPASE-ACTIVATING PROTEIN 4 enzyme activator activity#GO:0008047;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 regulation of cell junction assembly#GO:1901888;regulation of synapse organization#GO:0050807;animal gross anatomical part developmental process#GO:0160108;regulation of biological quality#GO:0065008;system development#GO:0048731;anatomical structure development#GO:0048856;regulation of synapse structure or activity#GO:0050803;regulation of cell motility#GO:2000145;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of cellular component biogenesis#GO:0044087;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of cell migration#GO:0030334;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;negative regulation of cell migration#GO:0030336;multicellular organism development#GO:0007275;regulation of locomotion#GO:0040012;nervous system development#GO:0007399;negative regulation of locomotion#GO:0040013;biological regulation#GO:0065007;negative regulation of cell motility#GO:2000146;multicellular organismal process#GO:0032501;regulation of synapse assembly#GO:0051963 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 G-protein modulator#PC00022;GTPase-activating protein#PC00257 CCKR signaling map#P06959>ARHGAP4#P07135;PDGF signaling pathway#P00047>Rho#P01174 HUMAN|HGNC=28637|UniProtKB=Q96II8 Q96II8 LRCH3 PTHR16083:SF7 LEUCINE RICH REPEAT CONTAINING PROTEIN DISP COMPLEX PROTEIN LRCH3 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 scaffold/adaptor protein#PC00226 HUMAN|HGNC=6632|UniProtKB=Q9HAT1 Q9HAT1 LMAN1L PTHR12223:SF31 VESICULAR MANNOSE-BINDING LECTIN PROTEIN ERGIC-53-LIKE monosaccharide binding#GO:0048029;carbohydrate binding#GO:0030246;binding#GO:0005488;small molecule binding#GO:0036094 endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;transport#GO:0006810;Golgi vesicle transport#GO:0048193;intracellular transport#GO:0046907;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649 endomembrane system#GO:0012505;cytoplasm#GO:0005737;membrane#GO:0016020;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;vesicle#GO:0031982;COPII-coated ER to Golgi transport vesicle#GO:0030134;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;coated vesicle#GO:0030135;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827 membrane traffic protein#PC00150 HUMAN|HGNC=23142|UniProtKB=Q17RD7 Q17RD7 SYT16 PTHR46129:SF4 SYNAPTOTAGMIN 14, ISOFORM D SYNAPTOTAGMIN-16 binding#GO:0005488;phospholipid binding#GO:0005543;lipid binding#GO:0008289 membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=11962|UniProtKB=O15417 O15417 TNRC18 PTHR12505:SF21 PHD FINGER TRANSCRIPTION FACTOR TRINUCLEOTIDE REPEAT-CONTAINING GENE 18 PROTEIN gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HUMAN|HGNC=25246|UniProtKB=Q9H0I2 Q9H0I2 ENKD1 PTHR21490:SF2 ENKURIN-RELATED ENKURIN DOMAIN-CONTAINING PROTEIN 1 cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;organelle#GO:0043226;cytoplasmic microtubule#GO:0005881;microtubule cytoskeleton#GO:0015630;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;microtubule#GO:0005874;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 HUMAN|HGNC=17310|UniProtKB=O60830 O60830 TIMM17B PTHR10485:SF2 MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM-17 MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM17-B transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;transmembrane protein transporter activity#GO:0008320 macromolecule localization#GO:0033036;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;mitochondrial protein import pathway#GO:7770058;protein import into mitochondrial matrix#GO:0030150;intracellular transport#GO:0046907;protein transmembrane import into intracellular organelle#GO:0044743;protein transmembrane transport#GO:0071806;intracellular protein transport#GO:0006886;transport#GO:0006810;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;intracellular protein transmembrane transport#GO:0065002;intracellular protein localization#GO:0008104;protein localization to mitochondrion#GO:0070585;mitochondrial transport#GO:0006839;protein localization to organelle#GO:0033365;mitochondrial transmembrane transport#GO:1990542;localization#GO:0051179;transmembrane transport#GO:0055085;cellular localization#GO:0051641;protein transport#GO:0015031 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle envelope#GO:0031967;membrane protein complex#GO:0098796;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;inner mitochondrial membrane protein complex#GO:0098800;organelle membrane#GO:0031090;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;TIM23 mitochondrial import inner membrane translocase complex#GO:0005744;mitochondrial membrane#GO:0031966;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;cytoplasm#GO:0005737 transporter#PC00227 HUMAN|HGNC=24921|UniProtKB=Q9BQI3 Q9BQI3 EIF2AK1 PTHR11042:SF160 EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 1 kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=23368|UniProtKB=Q9H7P6 Q9H7P6 MVB12B PTHR31547:SF1 MULTIVESICULAR BODY SUBUNIT 12B MULTIVESICULAR BODY SUBUNIT 12B regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;regulation of ERBB signaling pathway#GO:1901184;regulation of biological process#GO:0050789;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of epidermal growth factor receptor signaling pathway#GO:0042058;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endosome membrane#GO:0010008;endosome#GO:0005768;cytoplasm#GO:0005737;late endosome#GO:0005770;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;vesicle membrane#GO:0012506;membrane#GO:0016020;ESCRT I complex#GO:0000813;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090 HUMAN|HGNC=12120|UniProtKB=A0A075B6W5 A0A075B6W5 TRAV23DV6 PTHR19343:SF0 T CELL RECEPTOR ALPHA VARIABLE 1-2 T CELL RECEPTOR ALPHA VARIABLE 23_DELTA VARIABLE 6 binding#GO:0005488;peptide binding#GO:0042277;antigen binding#GO:0003823 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=16108|UniProtKB=Q8TDL5 Q8TDL5 BPIFB1 PTHR47395:SF1 BPI FOLD-CONTAINING FAMILY B MEMBER 1 BPI FOLD-CONTAINING FAMILY B MEMBER 1 response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of cell communication#GO:0010648;immune system process#GO:0002376;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;defense response to other organism#GO:0098542;regulation of response to external stimulus#GO:0032101;negative regulation of signal transduction#GO:0009968;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;defense response to symbiont#GO:0140546;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;response to external biotic stimulus#GO:0043207;regulation of cell communication#GO:0010646;regulation of response to biotic stimulus#GO:0002831;regulation of immune response#GO:0050776;regulation of defense response#GO:0031347;negative regulation of response to stimulus#GO:0048585;regulation of signal transduction#GO:0009966;negative regulation of immune system process#GO:0002683;biological regulation#GO:0065007;response to other organism#GO:0051707;immune response#GO:0006955;regulation of innate immune response#GO:0045088;innate immune response#GO:0045087;response to external stimulus#GO:0009605;defense response#GO:0006952;negative regulation of cellular process#GO:0048523;regulation of response to stress#GO:0080134;regulation of response to stimulus#GO:0048583 HUMAN|HGNC=30661|UniProtKB=Q9UBT2 Q9UBT2 UBA2 PTHR10953:SF5 UBIQUITIN-ACTIVATING ENZYME E1 SUMO-ACTIVATING ENZYME SUBUNIT 2 ligase activity, forming carbon-sulfur bonds#GO:0016877;ATP-dependent activity#GO:0140657;thiosulfate-cyanide sulfurtransferase activity#GO:0004792;sulfurtransferase activity#GO:0016783;transferase activity, transferring sulphur-containing groups#GO:0016782;nucleotidyltransferase activity#GO:0016779;catalytic activity#GO:0003824;transferase activity#GO:0016740;ligase activity#GO:0016874;transferase activity, transferring phosphorus-containing groups#GO:0016772;ubiquitin-like modifier activating enzyme activity#GO:0008641;catalytic activity, acting on a protein#GO:0140096 post-translational protein modification#GO:0043687;cellular process#GO:0009987;protein modification by small protein conjugation#GO:0032446;protein modification process#GO:0036211;primary metabolic process#GO:0044238;protein sumoylation#GO:0016925;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;catalytic complex#GO:1902494 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Ubiquitin proteasome pathway#P00060>E1#P01492 HUMAN|HGNC=950|UniProtKB=Q92560 Q92560 BAP1 PTHR10589:SF28 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE BAP1 peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity, acting on a protein#GO:0140096;cysteine-type deubiquitinase activity#GO:0004843;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005 regulation of biological process#GO:0050789;heterochromatin formation#GO:0031507;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;negative regulation of gene expression, epigenetic#GO:0045814;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;epigenetic regulation of gene expression#GO:0040029;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;heterochromatin organization#GO:0070828;chromatin organization#GO:0006325;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;cellular component assembly#GO:0022607 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 cysteine protease#PC00081;protein modifying enzyme#PC00260;protease#PC00190 HUMAN|HGNC=24589|UniProtKB=Q4L180 Q4L180 FILIP1L PTHR23166:SF4 FILAMIN/GPBP-INTERACTING PROTEIN FILAMIN A-INTERACTING PROTEIN 1-LIKE protein localization to organelle#GO:0033365;localization#GO:0051179;intracellular protein localization#GO:0008104;protein localization to cytoskeleton#GO:0044380;macromolecule localization#GO:0033036 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;actin cytoskeleton#GO:0015629 HUMAN|HGNC=25981|UniProtKB=Q9NXH8 Q9NXH8 TOR4A PTHR10760:SF1 TORSIN TORSIN-4A intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;organelle lumen#GO:0043233;organelle envelope#GO:0031967;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;cytoplasm#GO:0005737;nuclear envelope#GO:0005635;endomembrane system#GO:0012505;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;endoplasmic reticulum lumen#GO:0005788;endoplasmic reticulum#GO:0005783 chaperone#PC00072 HUMAN|HGNC=21259|UniProtKB=Q6IMN6 Q6IMN6 CAPRIN2 PTHR22922:SF5 GPI-ANCHORED PROTEIN P137 CAPRIN-2 signaling receptor binding#GO:0005102;protein binding#GO:0005515 regulation of Wnt signaling pathway#GO:0030111;regulation of cell communication#GO:0010646;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of Wnt signaling pathway#GO:0030177;positive regulation of response to stimulus#GO:0048584;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of canonical Wnt signaling pathway#GO:0060828;positive regulation of canonical Wnt signaling pathway#GO:0090263;regulation of response to stimulus#GO:0048583 RNA metabolism protein#PC00031 HUMAN|HGNC=8710|UniProtKB=Q9Y5G1 Q9Y5G1 PCDHGB3 PTHR24028:SF350 CADHERIN-87A PROTOCADHERIN GAMMA-B3-RELATED cell adhesion#GO:0007155;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 cadherin#PC00057;cell adhesion molecule#PC00069 HUMAN|HGNC=20718|UniProtKB=Q8TE49 Q8TE49 OTUD7A PTHR13367:SF9 UBIQUITIN THIOESTERASE OTU DOMAIN-CONTAINING PROTEIN 7A cysteine-type peptidase activity#GO:0008234;cysteine-type deubiquitinase activity#GO:0004843;catalytic activity#GO:0003824;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787 macromolecule metabolic process#GO:0043170;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511;protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;catabolic process#GO:0009056;post-translational protein modification#GO:0043687;protein modification process#GO:0036211;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987 nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 cysteine protease#PC00081;protease#PC00190 HUMAN|HGNC=17101|UniProtKB=Q15022 Q15022 SUZ12 PTHR22597:SF0 POLYCOMB GROUP PROTEIN POLYCOMB PROTEIN SUZ12 DNA binding#GO:0003677;binding#GO:0005488;nucleic acid binding#GO:0003676;chromatin binding#GO:0003682;chromatin DNA binding#GO:0031490 chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;heterochromatin formation#GO:0031507;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;heterochromatin organization#GO:0070828;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;chromatin organization#GO:0006325;cellular component assembly#GO:0022607;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of gene expression#GO:0010468;constitutive heterochromatin formation#GO:0140719;negative regulation of gene expression, epigenetic#GO:0045814;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;DNA methylation-dependent constitutive heterochromatin formation#GO:0006346;negative regulation of cellular process#GO:0048523 nuclear protein-containing complex#GO:0140513;histone methyltransferase complex#GO:0035097;transferase complex#GO:1990234;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;PcG protein complex#GO:0031519;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;methyltransferase complex#GO:0034708;organelle#GO:0043226;organelle lumen#GO:0043233 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=3378|UniProtKB=Q9H4G0 Q9H4G0 EPB41L1 PTHR23280:SF24 4.1 G PROTEIN BAND 4.1-LIKE PROTEIN 1 cell junction#GO:0030054;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;anchoring junction#GO:0070161;membrane#GO:0016020;cell-cell junction#GO:0005911;cell periphery#GO:0071944 actin or actin-binding cytoskeletal protein#PC00041;cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 Nicotine pharmacodynamics pathway#P06587>EPB41L1#P06599;Dopamine receptor mediated signaling pathway#P05912>EPB41L1#P05953;Dopamine receptor mediated signaling pathway#P05912>EPB41#P05966 HUMAN|HGNC=25070|UniProtKB=Q96AP0 Q96AP0 ACD PTHR14487:SF3 ADRENOCORTICAL DYSPLASIA PROTEIN ACD ADRENOCORTICAL DYSPLASIA PROTEIN HOMOLOG HUMAN|HGNC=4098|UniProtKB=P0DTW1 P0DTW1 GAGE1 PTHR14047:SF30 P ANTIGEN FAMILY MEMBER 5-RELATED G ANTIGEN 1-RELATED HUMAN|HGNC=3254|UniProtKB=Q9BY44 Q9BY44 EIF2A PTHR13227:SF0 EUKARYOTIC TRANSLATION INITIATION FACTOR 2A EUKARYOTIC TRANSLATION INITIATION FACTOR 2A translation factor activity#GO:0180051;translation initiation factor activity#GO:0003743 metabolic process#GO:0008152;translation#GO:0006412;translational initiation#GO:0006413;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;biosynthetic process#GO:0009058 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 translational protein#PC00263;translation initiation factor#PC00224;translation factor#PC00223 Gonadotropin-releasing hormone receptor pathway#P06664>EIF2A#P06762 HUMAN|HGNC=30626|UniProtKB=Q96MU7 Q96MU7 YTHDC1 PTHR12357:SF3 YTH YT521-B HOMOLOGY DOMAIN-CONTAINING YTH DOMAIN-CONTAINING PROTEIN 1 protein-RNA adaptor activity#GO:0140517;protein-macromolecule adaptor activity#GO:0030674;mRNA binding#GO:0003729;molecular adaptor activity#GO:0060090;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 regulation of mRNA metabolic process#GO:1903311;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;mRNA processing#GO:0006397;regulation of alternative mRNA splicing, via spliceosome#GO:0000381;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;mRNA metabolic process#GO:0016071;regulation of biological process#GO:0050789;mRNA splicing, via spliceosome#GO:0000398;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;nucleobase-containing compound metabolic process#GO:0006139;regulation of RNA splicing#GO:0043484;biosynthetic process#GO:0009058;biological regulation#GO:0065007;regulation of mRNA processing#GO:0050684;regulation of nucleobase-containing compound metabolic process#GO:0019219;macromolecule biosynthetic process#GO:0009059;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA splicing, via transesterification reactions#GO:0000375;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of mRNA splicing, via spliceosome#GO:0048024;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031 HUMAN|HGNC=29455|UniProtKB=Q6UX27 Q6UX27 VSTM1 PTHR11738:SF180 MHC CLASS I NK CELL RECEPTOR V-SET AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 1 transmembrane signaling receptor activity#GO:0004888;immune receptor activity#GO:0140375;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 regulation of immune response#GO:0050776;cell surface receptor signaling pathway#GO:0007166;regulation of response to stimulus#GO:0048583;cell communication#GO:0007154;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;immune response-regulating signaling pathway#GO:0002764;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;signaling#GO:0023052 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=11715|UniProtKB=Q15562 Q15562 TEAD2 PTHR11834:SF5 TRANSCRIPTIONAL ENHANCER FACTOR TEF RELATED TRANSCRIPTIONAL ENHANCER FACTOR TEF-4 DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;regulation of macromolecule metabolic process#GO:0060255;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;signaling#GO:0023052;animal gross anatomical part developmental process#GO:0160108;embryonic organ development#GO:0048568;cell communication#GO:0007154;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;intracellular signal transduction#GO:0035556;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;hippo signaling#GO:0035329;embryo development#GO:0009790;developmental process#GO:0032502;multicellular organism development#GO:0007275;animal organ development#GO:0048513;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 transcription regulator complex#GO:0005667;protein-containing complex#GO:0032991 helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=18619|UniProtKB=Q96JB2 Q96JB2 COG3 PTHR13302:SF8 CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 3 CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 3 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;cargo adaptor activity#GO:0140312 retrograde transport, vesicle recycling within Golgi#GO:0000301;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;intra-Golgi vesicle-mediated transport#GO:0006891;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;transport#GO:0006810;Golgi vesicle transport#GO:0048193;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;COG complex#GO:0017119;vesicle tethering complex#GO:0099023;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=7818|UniProtKB=Q02577 Q02577 NHLH2 PTHR13864:SF19 T-CELL ACUTE LYMPHOCYTIC LEUKEMIA/STEM CELL LEUKEMIA-RELATED HELIX-LOOP-HELIX PROTEIN 2 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=22211|UniProtKB=A0FGR8 A0FGR8 ESYT2 PTHR45761:SF2 EXTENDED SYNAPTOTAGMIN-LIKE PROTEIN 2, ISOFORM C EXTENDED SYNAPTOTAGMIN-2 metal ion binding#GO:0046872;cation binding#GO:0043169;lipid binding#GO:0008289;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;binding#GO:0005488;calcium ion binding#GO:0005509;phosphatidylcholine binding#GO:0031210;phospholipid binding#GO:0005543;phosphatidylinositol binding#GO:0035091 membrane#GO:0016020;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endoplasmic reticulum membrane#GO:0005789;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622 membrane trafficking regulatory protein#PC00151;membrane traffic protein#PC00150 HUMAN|HGNC=31046|UniProtKB=Q96GZ6 Q96GZ6 SLC41A3 PTHR16228:SF22 DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41 SOLUTE CARRIER FAMILY 41 MEMBER 3 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 HUMAN|HGNC=1991|UniProtKB=P12277 P12277 CKB PTHR11547:SF23 ARGININE OR CREATINE KINASE CREATINE KINASE B-TYPE catalytic activity#GO:0003824;transferase activity#GO:0016740;phosphotransferase activity, nitrogenous group as acceptor#GO:0016775;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 phosphorus metabolic process#GO:0006793;modified amino acid metabolic process#GO:0006575;metabolic process#GO:0008152;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;organophosphate biosynthetic process#GO:0090407;biosynthetic process#GO:0009058 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;amino acid kinase#PC00045 HUMAN|HGNC=16061|UniProtKB=Q9NQU5 Q9NQU5 PAK6 PTHR48015:SF19 SERINE/THREONINE-PROTEIN KINASE TAO SERINE_THREONINE-PROTEIN KINASE PAK 6 protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096 signal transduction#GO:0007165;cellular process#GO:0009987;response to nutrient levels#GO:0031667;response to stress#GO:0006950;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of MAPK cascade#GO:0043408;cellular response to nutrient levels#GO:0031669;regulation of response to stimulus#GO:0048583;cellular response to starvation#GO:0009267;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to starvation#GO:0042594;signaling#GO:0023052;regulation of cell communication#GO:0010646;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cellular response to stress#GO:0033554;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Cytoskeletal regulation by Rho GTPase#P00016>PAK#P00517;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PAK#P00837 HUMAN|HGNC=29038|UniProtKB=Q5T2D3 Q5T2D3 OTUD3 PTHR12419:SF117 OTU DOMAIN CONTAINING PROTEIN OTU DOMAIN-CONTAINING PROTEIN 3 hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity#GO:0003824;cysteine-type deubiquitinase activity#GO:0004843;cysteine-type peptidase activity#GO:0008234 biological regulation#GO:0065007;regulation of biological quality#GO:0065008;protein stabilization#GO:0050821;regulation of protein stability#GO:0031647 cysteine protease#PC00081 HUMAN|HGNC=74|UniProtKB=Q9UNQ0 Q9UNQ0 ABCG2 PTHR48041:SF92 ABC TRANSPORTER G FAMILY MEMBER 28 BROAD SUBSTRATE SPECIFICITY ATP-BINDING CASSETTE TRANSPORTER ABCG2 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657;efflux transmembrane transporter activity#GO:0015562;active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399 transport#GO:0006810;xenobiotic transport#GO:0042908;system process#GO:0003008;establishment of localization#GO:0051234;cellular process#GO:0009987;detoxification of inorganic compound#GO:0061687;detoxification#GO:0098754;multicellular organismal process#GO:0032501;response to chemical#GO:0042221;circulatory system process#GO:0003013;inorganic anion transport#GO:0015698;transmembrane transport#GO:0055085;localization#GO:0051179;export from cell#GO:0140352;response to toxic substance#GO:0009636;response to stimulus#GO:0050896 cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;plasma membrane#GO:0005886;membrane#GO:0016020;apical plasma membrane#GO:0016324;cell periphery#GO:0071944;apical part of cell#GO:0045177 primary active transporter#PC00068;transporter#PC00227;ATP-binding cassette (ABC) transporter#PC00003 HUMAN|HGNC=28148|UniProtKB=Q96LW7 Q96LW7 CARD19 PTHR34765:SF1 CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 19 CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 19 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HUMAN|HGNC=11504|UniProtKB=O15056 O15056 SYNJ2 PTHR11200:SF148 INOSITOL 5-PHOSPHATASE POLYPHOSPHATIDYLINOSITOL PHOSPHATASE SYNJ2 phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578 vesicle-mediated transport#GO:0016192;synaptic vesicle recycling#GO:0036465;endocytosis#GO:0006897;synaptic vesicle endocytosis#GO:0048488;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;localization#GO:0051179;establishment of localization#GO:0051234;import into cell#GO:0098657;vesicle-mediated transport in synapse#GO:0099003;cellular localization#GO:0051641;synaptic vesicle cycle#GO:0099504;transport#GO:0006810 perinuclear region of cytoplasm#GO:0048471;cytoplasm#GO:0005737;synapse#GO:0045202;cellular anatomical structure#GO:0110165;presynapse#GO:0098793;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;cell junction#GO:0030054 hydrolase#PC00121;phosphatase#PC00181 HUMAN|HGNC=3129|UniProtKB=Q14213 Q14213 EBI3 PTHR48483:SF2 INTERLEUKIN-27 SUBUNIT BETA INTERLEUKIN-27 SUBUNIT BETA protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488;cytokine receptor binding#GO:0005126 cell activation#GO:0001775;cell population proliferation#GO:0008283;T cell proliferation#GO:0042098;immune system process#GO:0002376;leukocyte proliferation#GO:0070661;cellular process#GO:0009987;T cell activation#GO:0042110;leukocyte activation#GO:0045321;multicellular organismal process#GO:0032501;lymphocyte proliferation#GO:0046651;mononuclear cell proliferation#GO:0032943;lymphocyte activation#GO:0046649 HUMAN|HGNC=23366|UniProtKB=Q9BPX5 Q9BPX5 ARPC5L PTHR12644:SF2 ARP2/3 COMPLEX 16 KD SUBUNIT P16-ARC ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 5-LIKE PROTEIN protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 cytoskeleton organization#GO:0007010;cell motility#GO:0048870;actin nucleation#GO:0045010;cell migration#GO:0016477;actin cytoskeleton organization#GO:0030036;Arp2/3 complex-mediated actin nucleation#GO:0034314;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029 cell periphery#GO:0071944;cell cortex#GO:0005938;cortical cytoskeleton#GO:0030863;actin cytoskeleton#GO:0015629;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;Arp2/3 protein complex#GO:0005885;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 actin or actin-binding cytoskeletal protein#PC00041 Integrin signalling pathway#P00034>Arp2/3#P00912;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Arp2/3#P00876;Huntington disease#P00029>Arp2/3 complex#P00811 HUMAN|HGNC=29659|UniProtKB=Q0VG99 Q0VG99 MESP2 PTHR20937:SF17 IP14615P MESODERM POSTERIOR PROTEIN 2 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;tissue development#GO:0009888;regionalization#GO:0003002;multicellular organismal process#GO:0032501;epithelium development#GO:0060429;mesoderm formation#GO:0001707;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;mesoderm morphogenesis#GO:0048332;heart morphogenesis#GO:0003007;animal organ morphogenesis#GO:0009887;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;embryo development ending in birth or egg hatching#GO:0009792;pattern specification process#GO:0007389;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;tissue morphogenesis#GO:0048729;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;embryonic pattern specification#GO:0009880;heart development#GO:0007507;embryo development#GO:0009790;anterior/posterior pattern specification#GO:0009952;mesoderm development#GO:0007498;anterior/posterior axis specification#GO:0009948;animal organ development#GO:0048513;embryonic morphogenesis#GO:0048598;multicellular organism development#GO:0007275;anatomical structure formation involved in morphogenesis#GO:0048646;gastrulation#GO:0007369;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;circulatory system development#GO:0072359;regulation of transcription by RNA polymerase II#GO:0006357;animal gross anatomical part developmental process#GO:0160108;chordate embryonic development#GO:0043009;formation of primary germ layer#GO:0001704 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=38606|UniProtKB=A8MW95 A8MW95 BECN2 PTHR12768:SF5 BECLIN 1 BECLIN-2 protein binding#GO:0005515;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;binding#GO:0005488;phosphatidylinositol 3-kinase binding#GO:0043548 cellular component organization or biogenesis#GO:0071840;autophagosome assembly#GO:0000045;metabolic process#GO:0008152;cellular component assembly#GO:0022607;vesicle-mediated transport#GO:0016192;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;response to stress#GO:0006950;establishment of localization in cell#GO:0051649;autophagy#GO:0006914;cellular process#GO:0009987;autophagosome organization#GO:1905037;cellular localization#GO:0051641;process utilizing autophagic mechanism#GO:0061919;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;late endosome to vacuole transport#GO:0045324;cellular component organization#GO:0016043;mitophagy#GO:0000423;establishment of localization#GO:0051234;cellular response to starvation#GO:0009267;intracellular transport#GO:0046907;autophagy of mitochondrion#GO:0000422;vacuolar transport#GO:0007034;cellular response to nutrient levels#GO:0031669;transport#GO:0006810;macroautophagy#GO:0016236;response to nutrient levels#GO:0031667;localization#GO:0051179;vacuole organization#GO:0007033;organelle assembly#GO:0070925;catabolic process#GO:0009056;response to starvation#GO:0042594;cellular response to stimulus#GO:0051716 membrane protein complex#GO:0098796;membrane#GO:0016020;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;phagophore assembly site#GO:0000407;transferase complex#GO:1990234;phosphatidylinositol 3-kinase complex, class III#GO:0035032;extrinsic component of membrane#GO:0019898;intracellular anatomical structure#GO:0005622 protease inhibitor#PC00191 HUMAN|HGNC=27268|UniProtKB=Q8TC21 Q8TC21 ZNF596 PTHR24381:SF30 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 596 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=11588|UniProtKB=P20226 P20226 TBP PTHR10126:SF42 TATA-BOX BINDING PROTEIN TATA-BOX-BINDING PROTEIN macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleic acid biosynthetic process#GO:0141187;DNA-templated transcription initiation#GO:0006352;gene expression#GO:0010467;RNA biosynthetic process#GO:0032774;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;DNA-templated transcription#GO:0006351;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 RNA metabolism protein#PC00031;general transcription factor#PC00259 General transcription by RNA polymerase I#P00022>TBP#P00657;Transcription regulation by bZIP transcription factor#P00055>TBP#P01399;Huntington disease#P00029>TBP#P00779 HUMAN|HGNC=19028|UniProtKB=Q9BRZ2 Q9BRZ2 TRIM56 PTHR25462:SF299 BONUS, ISOFORM C-RELATED E3 UBIQUITIN-PROTEIN LIGASE TRIM56 ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824 positive regulation of biological process#GO:0048518;defense response to symbiont#GO:0140546;response to stress#GO:0006950;positive regulation of immune system process#GO:0002684;regulation of response to cytokine stimulus#GO:0060759;response to biotic stimulus#GO:0009607;regulation of response to external stimulus#GO:0032101;defense response to other organism#GO:0098542;regulation of cytokine-mediated signaling pathway#GO:0001959;positive regulation of response to external stimulus#GO:0032103;regulation of biological process#GO:0050789;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;regulation of signaling#GO:0023051;immune system process#GO:0002376;positive regulation of cytokine-mediated signaling pathway#GO:0001961;positive regulation of signaling#GO:0023056;positive regulation of innate immune response#GO:0045089;positive regulation of cellular process#GO:0048522;immune response#GO:0006955;response to other organism#GO:0051707;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;positive regulation of defense response#GO:0031349;regulation of response to stress#GO:0080134;defense response#GO:0006952;positive regulation of response to biotic stimulus#GO:0002833;response to external stimulus#GO:0009605;innate immune response#GO:0045087;regulation of innate immune response#GO:0045088;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;regulation of response to biotic stimulus#GO:0002831;response to external biotic stimulus#GO:0043207;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of defense response#GO:0031347;regulation of immune response#GO:0050776 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=30580|UniProtKB=Q76I76 Q76I76 SSH2 PTHR45864:SF3 SLINGSHOT PROTEIN PHOSPHATASE HOMOLOG PROTEIN PHOSPHATASE SLINGSHOT HOMOLOG 2 cytoskeletal protein binding#GO:0008092;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;actin binding#GO:0003779;binding#GO:0005488;phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787;protein binding#GO:0005515 negative regulation of protein polymerization#GO:0032272;actin filament-based process#GO:0030029;negative regulation of cytoskeleton organization#GO:0051494;negative regulation of protein-containing complex assembly#GO:0031333;negative regulation of organelle organization#GO:0010639;negative regulation of cellular component organization#GO:0051129;regulation of supramolecular fiber organization#GO:1902903;regulation of cytoskeleton organization#GO:0051493;negative regulation of supramolecular fiber organization#GO:1902904;regulation of protein polymerization#GO:0032271;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;negative regulation of cellular process#GO:0048523;regulation of actin filament-based process#GO:0032970;regulation of actin filament organization#GO:0110053;regulation of actin filament polymerization#GO:0030833;biological regulation#GO:0065007;regulation of actin polymerization or depolymerization#GO:0008064;regulation of actin filament length#GO:0030832;regulation of biological quality#GO:0065008;negative regulation of biological process#GO:0048519;regulation of protein-containing complex assembly#GO:0043254;cellular component organization#GO:0016043;regulation of cellular component size#GO:0032535;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;regulation of cellular component organization#GO:0051128;negative regulation of actin filament polymerization#GO:0030837;regulation of cellular component biogenesis#GO:0044087;regulation of anatomical structure size#GO:0090066;cellular component organization or biogenesis#GO:0071840;organelle organization#GO:0006996;cellular process#GO:0009987;cytoskeleton organization#GO:0007010;regulation of actin cytoskeleton organization#GO:0032956 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195 Cytoskeletal regulation by Rho GTPase#P00016>Slingshot#P00509 HUMAN|HGNC=18570|UniProtKB=Q8IUE1 Q8IUE1 TGIF2LX PTHR11850:SF205 HOMEOBOX PROTEIN TRANSCRIPTION FACTORS HOMEOBOX PROTEIN TGIF2LX-RELATED RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=6764|UniProtKB=Q9UI95 Q9UI95 MAD2L2 PTHR11842:SF10 MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2 MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2B macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;DNA damage response#GO:0006974;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139;response to stress#GO:0006950;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;transferase complex, transferring phosphorus-containing groups#GO:0061695;DNA polymerase complex#GO:0042575;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex#GO:1990234;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=3275|UniProtKB=O00303 O00303 EIF3F PTHR10540:SF16 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F binding#GO:0005488;deubiquitinase activity#GO:0101005;metallopeptidase activity#GO:0008237;protein binding#GO:0005515;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;translation factor activity#GO:0180051;translation initiation factor binding#GO:0031369;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein peptidase activity#GO:0019783;translation initiation factor activity#GO:0003743;peptidase activity#GO:0008233 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;translational initiation#GO:0006413;translation#GO:0006412;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;eukaryotic translation initiation factor 3 complex#GO:0005852 translation initiation factor#PC00224 HUMAN|HGNC=16121|UniProtKB=Q9BQN1 Q9BQN1 FAM83C PTHR16181:SF29 PROTEIN FAM83A-RELATED PROTEIN FAM83C protein binding#GO:0005515;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;kinase binding#GO:0019900;binding#GO:0005488 cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052 HUMAN|HGNC=24108|UniProtKB=Q7Z591 Q7Z591 AKNA PTHR21510:SF15 AKNA DOMAIN-CONTAINING PROTEIN MICROTUBULE ORGANIZATION PROTEIN AKNA biological regulation#GO:0065007;head development#GO:0060322;nervous system development#GO:0007399;brain development#GO:0007420;negative regulation of cell adhesion#GO:0007162;negative regulation of cell-cell adhesion#GO:0022408;regulation of cell adhesion#GO:0030155;multicellular organismal process#GO:0032501;tissue development#GO:0009888;cellular process#GO:0009987;mesenchyme development#GO:0060485;neurogenesis#GO:0022008;multicellular organism development#GO:0007275;animal organ development#GO:0048513;cellular developmental process#GO:0048869;developmental process#GO:0032502;mesenchymal cell differentiation#GO:0048762;negative regulation of cellular process#GO:0048523;cell differentiation#GO:0030154;central nervous system development#GO:0007417;regulation of cell-cell adhesion#GO:0022407;forebrain development#GO:0030900;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cell division#GO:0051301;negative regulation of biological process#GO:0048519;system development#GO:0048731;anatomical structure development#GO:0048856;cell population proliferation#GO:0008283;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108 supramolecular complex#GO:0099080;organelle#GO:0043226;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;microtubule#GO:0005874;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;centrosome#GO:0005813;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 HUMAN|HGNC=30811|UniProtKB=A8K4G0 A8K4G0 CD300LB PTHR11860:SF103 POLYMERIC-IMMUNOGLOBULIN RECEPTOR CMRF35-LIKE MOLECULE 7 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;immune response-activating signaling pathway#GO:0002757;activation of immune response#GO:0002253;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of immune system process#GO:0002684;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;regulation of immune response#GO:0050776;immune system process#GO:0002376;cell communication#GO:0007154;regulation of biological process#GO:0050789;immune response-regulating signaling pathway#GO:0002764;cellular response to stimulus#GO:0051716;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=7436|UniProtKB=P42898 P42898 MTHFR PTHR45754:SF3 METHYLENETETRAHYDROFOLATE REDUCTASE METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH) oxidoreductase activity#GO:0016491;heterocyclic compound binding#GO:1901363;nucleotide binding#GO:0000166;catalytic activity#GO:0003824;anion binding#GO:0043168;small molecule binding#GO:0036094;flavin adenine dinucleotide binding#GO:0050660;binding#GO:0005488;ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265 oxoacid metabolic process#GO:0043436;tetrahydrofolate biosynthetic process#GO:0046654;tetrahydrofolate metabolic process#GO:0046653;modified amino acid metabolic process#GO:0006575;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;carboxylic acid biosynthetic process#GO:0046394;small molecule metabolic process#GO:0044281;pteridine-containing compound metabolic process#GO:0042558;folic acid-containing compound metabolic process#GO:0006760;metabolic process#GO:0008152;amino acid biosynthetic process#GO:0008652;small molecule biosynthetic process#GO:0044283;proteinogenic amino acid biosynthetic process#GO:0170038;sulfur compound metabolic process#GO:0006790;aspartate family amino acid biosynthetic process#GO:0009067;cellular process#GO:0009987;proteinogenic amino acid metabolic process#GO:0170039;biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 reductase#PC00198 HUMAN|HGNC=5412|UniProtKB=P13164 P13164 IFITM1 PTHR13999:SF6 INTERFERON INDUCIBLE TRANSMEMBRANE PROTEIN INTERFERON-INDUCED TRANSMEMBRANE PROTEIN 1 immune response#GO:0006955;response to other organism#GO:0051707;biological regulation#GO:0065007;defense response#GO:0006952;response to external stimulus#GO:0009605;innate immune response#GO:0045087;cellular response to stimulus#GO:0051716;response to external biotic stimulus#GO:0043207;regulation of cellular process#GO:0050794;cytokine-mediated signaling pathway#GO:0019221;response to virus#GO:0009615;cell communication#GO:0007154;response to type II interferon#GO:0034341;cellular process#GO:0009987;signal transduction#GO:0007165;defense response to symbiont#GO:0140546;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;defense response to other organism#GO:0098542;response to chemical#GO:0042221;response to cytokine#GO:0034097;cell surface receptor signaling pathway#GO:0007166;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;defense response to virus#GO:0051607;negative regulation of biological process#GO:0048519;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;type I interferon-mediated signaling pathway#GO:0060337;immune system process#GO:0002376;response to peptide#GO:1901652 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090 HUMAN|HGNC=6478|UniProtKB=Q6ISS4 Q6ISS4 LAIR2 PTHR11738:SF129 MHC CLASS I NK CELL RECEPTOR LEUKOCYTE-ASSOCIATED IMMUNOGLOBULIN-LIKE RECEPTOR 1-RELATED transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;immune receptor activity#GO:0140375 regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166;regulation of immune response#GO:0050776;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;immune response-regulating signaling pathway#GO:0002764;regulation of biological process#GO:0050789;signal transduction#GO:0007165;immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;response to stimulus#GO:0050896 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=21686|UniProtKB=O00584 O00584 RNASET2 PTHR11240:SF94 RIBONUCLEASE T2 RIBONUCLEASE T2 catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;RNA endonuclease activity#GO:0004521;catalytic activity, acting on RNA#GO:0140098;nuclease activity#GO:0004518;RNA nuclease activity#GO:0004540;endonuclease activity#GO:0004519 nucleic acid catabolic process#GO:0141188;cellular process#GO:0009987;nucleobase-containing compound catabolic process#GO:0034655;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;nucleobase-containing compound metabolic process#GO:0006139;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 endoribonuclease#PC00094 HUMAN|HGNC=20341|UniProtKB=Q8IZN3 Q8IZN3 ZDHHC14 PTHR22883:SF28 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE ZDHHC14 acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824;palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity, acting on a protein#GO:0140096 protein targeting to membrane#GO:0006612;localization within membrane#GO:0051668;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;establishment of protein localization to membrane#GO:0090150;establishment of protein localization#GO:0045184;cellular process#GO:0009987;protein targeting#GO:0006605 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HUMAN|HGNC=1917|UniProtKB=O14647 O14647 CHD2 PTHR45623:SF19 CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED ATP-DEPENDENT CHROMATIN REMODELER CHD2 ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;pyrophosphatase activity#GO:0016462;histone binding#GO:0042393;DNA binding#GO:0003677;hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887;nucleic acid binding#GO:0003676;chromatin binding#GO:0003682;catalytic activity, acting on DNA#GO:0140097;hydrolase activity, acting on acid anhydrides#GO:0016817;ATP-dependent activity, acting on DNA#GO:0008094;protein binding#GO:0005515;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP-dependent activity#GO:0140657 chromatin remodeling#GO:0006338;chromatin organization#GO:0006325;cellular process#GO:0009987;cellular component organization#GO:0016043;protein-containing complex organization#GO:0043933;protein-DNA complex organization#GO:0071824;cellular component organization or biogenesis#GO:0071840;nucleosome organization#GO:0034728 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=8718|UniProtKB=Q9Y5F6 Q9Y5F6 PCDHGC5 PTHR24028:SF349 CADHERIN-87A PROTOCADHERIN GAMMA-C5 cellular component organization#GO:0016043;cellular process#GO:0009987;cell adhesion#GO:0007155;synapse organization#GO:0050808;cell junction organization#GO:0034330;cellular component organization or biogenesis#GO:0071840 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 cadherin#PC00057;cell adhesion molecule#PC00069 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HUMAN|HGNC=21172|UniProtKB=Q7Z6V5 Q7Z6V5 ADAT2 PTHR11079:SF208 CYTOSINE DEAMINASE FAMILY MEMBER TRNA-SPECIFIC ADENOSINE-34 DEAMINASE CATALYTIC SUBUNIT ADAT2 tRNA-specific adenosine deaminase activity#GO:0008251;catalytic activity, acting on a tRNA#GO:0140101;adenosine deaminase activity#GO:0004000;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;deaminase activity#GO:0019239;catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810 adenosine to inosine editing#GO:0006382;tRNA wobble base modification#GO:0002097;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;tRNA modification#GO:0006400;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;base conversion or substitution editing#GO:0016553;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 hydrolase#PC00121;metabolite interconversion enzyme#PC00262;deaminase#PC00088 De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>dCTP deaminase#P02920;Salvage pyrimidine ribonucleotides#P02775>Cytosine deaminase#P03155;Salvage pyrimidine deoxyribonucleotides#P02774>Cytidine deaminase#P03144;Salvage pyrimidine ribonucleotides#P02775>Cytidine deaminase#P03154 HUMAN|HGNC=14461|UniProtKB=Q8WTU2 Q8WTU2 SSC4D PTHR19331:SF439 SCAVENGER RECEPTOR DOMAIN-CONTAINING SCAVENGER RECEPTOR CYSTEINE-RICH DOMAIN-CONTAINING GROUP B PROTEIN cargo receptor activity#GO:0038024 serine protease#PC00203;protease#PC00190 HUMAN|HGNC=29008|UniProtKB=Q9UEG4 Q9UEG4 ZNF629 PTHR24376:SF78 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 629 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HUMAN|HGNC=17955|UniProtKB=O43504 O43504 LAMTOR5 PTHR13342:SF4 RAGULATOR COMPLEX PROTEIN LAMTOR5 RAGULATOR COMPLEX PROTEIN LAMTOR5 guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234 regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;regulation of TORC1 signaling#GO:1903432;regulation of TOR signaling#GO:0032006;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;response to acid chemical#GO:0001101;positive regulation of TORC1 signaling#GO:1904263;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of response to stimulus#GO:0048584;response to chemical#GO:0042221;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;cellular response to chemical stimulus#GO:0070887;positive regulation of TOR signaling#GO:0032008;positive regulation of signaling#GO:0023056;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;response to stimulus#GO:0050896;cellular response to amino acid stimulus#GO:0071230 vacuolar membrane#GO:0005774;lytic vacuole#GO:0000323;intracellular protein-containing complex#GO:0140535;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane#GO:0016020;protein-containing complex#GO:0032991;guanyl-nucleotide exchange factor complex#GO:0032045;cytoplasm#GO:0005737;vacuole#GO:0005773;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane protein complex#GO:0098796;lysosome#GO:0005764;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=26171|UniProtKB=Q0VG06 Q0VG06 FAAP100 PTHR14890:SF1 FANCONI ANEMIA CORE COMPLEX-ASSOCIATED PROTEIN 100 FANCONI ANEMIA CORE COMPLEX-ASSOCIATED PROTEIN 100 nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=19705|UniProtKB=Q86XS5 Q86XS5 ANGPTL5 PTHR19143:SF185 FIBRINOGEN/TENASCIN/ANGIOPOEITIN ANGIOPOIETIN-RELATED PROTEIN 5 extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HUMAN|HGNC=43616|UniProtKB=P59074 P59074 CHMP4BP1 PTHR22761:SF41 CHARGED MULTIVESICULAR BODY PROTEIN CHARGED MULTIVESICULAR BODY PROTEIN 4B-LIKE PROTEIN CHMP4BP1-RELATED endosomal transport#GO:0016197;vesicle budding from membrane#GO:0006900;nuclear envelope organization#GO:0006998;vesicle organization#GO:0016050;cellular component organization or biogenesis#GO:0071840;nucleus organization#GO:0006997;establishment of localization#GO:0051234;vacuolar transport#GO:0007034;transport#GO:0006810;intracellular transport#GO:0046907;membrane organization#GO:0061024;endomembrane system organization#GO:0010256;endosome transport via multivesicular body sorting pathway#GO:0032509;cellular component assembly#GO:0022607;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;multivesicular body sorting pathway#GO:0071985;late endosome to vacuole transport via multivesicular body sorting pathway#GO:0032511;nuclear membrane organization#GO:0071763;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;localization#GO:0051179;cellular localization#GO:0051641;late endosome to vacuole transport#GO:0045324;membrane assembly#GO:0071709;cellular component organization#GO:0016043 side of membrane#GO:0098552;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endosome#GO:0005768;endosome membrane#GO:0010008;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;organelle envelope#GO:0031967;membrane protein complex#GO:0098796;cytoplasmic side of plasma membrane#GO:0009898;vesicle#GO:0031982;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;cytoplasmic side of membrane#GO:0098562;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;late endosome#GO:0005770;protein-containing complex#GO:0032991;nuclear envelope#GO:0005635;plasma membrane#GO:0005886;cytoplasm#GO:0005737;vesicle membrane#GO:0012506;membrane#GO:0016020;nucleus#GO:0005634;cell periphery#GO:0071944 membrane traffic protein#PC00150 HUMAN|HGNC=13026|UniProtKB=Q9UNY5 Q9UNY5 ZNF232 PTHR23226:SF54 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER PROTEIN 232 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=13244|UniProtKB=Q5C9Z4 Q5C9Z4 NOM1 PTHR18034:SF4 CELL CYCLE CONTROL PROTEIN CWF22-RELATED NUCLEOLAR MIF4G DOMAIN-CONTAINING PROTEIN 1 binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 cellular component organization or biogenesis#GO:0071840;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;ribosomal small subunit biogenesis#GO:0042274 intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013 RNA processing factor#PC00147 HUMAN|HGNC=12801|UniProtKB=P17861 P17861 XBP1 PTHR46542:SF1 X-BOX BINDING PROTEIN 1 X-BOX-BINDING PROTEIN 1 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=20767|UniProtKB=Q53GG5 Q53GG5 PDLIM3 PTHR24214:SF7 PDZ AND LIM DOMAIN PROTEIN ZASP PDZ AND LIM DOMAIN PROTEIN 3 protein binding#GO:0005515;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779 anatomical structure development#GO:0048856;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;actin filament-based process#GO:0030029;actin cytoskeleton organization#GO:0030036;muscle structure development#GO:0061061;circulatory system development#GO:0072359;cellular component organization#GO:0016043;animal organ development#GO:0048513;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;developmental process#GO:0032502;multicellular organismal process#GO:0032501;heart development#GO:0007507;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular process#GO:0009987 polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;cell junction#GO:0030054;sarcomere#GO:0030017;adherens junction#GO:0005912;cytoskeleton#GO:0005856;stress fiber#GO:0001725;actin filament#GO:0005884;I band#GO:0031674;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cell-cell junction#GO:0005911;Z disc#GO:0030018;actomyosin#GO:0042641;contractile muscle fiber#GO:0043292;actin filament bundle#GO:0032432;myofibril#GO:0030016;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;supramolecular fiber#GO:0099512;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;actin cytoskeleton#GO:0015629 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=172|UniProtKB=P36896 P36896 ACVR1B PTHR23255:SF22 TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II ACTIVIN RECEPTOR TYPE-1B transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488;protein serine/threonine kinase activity#GO:0004674;protein-containing complex binding#GO:0044877;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein serine/threonine kinase activity#GO:0004675;kinase activity#GO:0016301;activin binding#GO:0048185;transferase activity#GO:0016740;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity, acting on a protein#GO:0140096 developmental process#GO:0032502;cell surface receptor signaling pathway#GO:0007166;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;multicellular organism development#GO:0007275;signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;nervous system development#GO:0007399;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;multicellular organismal process#GO:0032501;activin receptor signaling pathway#GO:0032924;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;cellular response to growth factor stimulus#GO:0071363;cell communication#GO:0007154;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to endogenous stimulus#GO:0009719;signaling#GO:0023052;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;response to growth factor#GO:0070848;regulation of cellular process#GO:0050794 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane#GO:0016020;membrane protein complex#GO:0098796;protein kinase complex#GO:1902911;serine/threonine protein kinase complex#GO:1902554;signaling receptor complex#GO:0043235;transferase complex#GO:1990234;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695 serine/threonine protein kinase receptor#PC00205 Wnt signaling pathway#P00057>TGFbetaactivated Kinase-1#P01442;Gonadotropin-releasing hormone receptor pathway#P06664>Alk4#P06845;TGF-beta signaling pathway#P00052>TGFbetareceptor I#P01278;TGF-beta signaling pathway#P00052>TGFbetareceptors#P01283 HUMAN|HGNC=1183|UniProtKB=Q9NQ90 Q9NQ90 ANO2 PTHR12308:SF20 ANOCTAMIN ANOCTAMIN-2 passive transmembrane transporter activity#GO:0022803;chloride transmembrane transporter activity#GO:0015108;ligand-gated channel activity#GO:0022834;transmembrane transporter activity#GO:0022857;lipid carrier activity#GO:0005319;phospholipid scramblase activity#GO:0017128;ligand-gated monoatomic ion channel activity#GO:0015276;intramembrane lipid carrier activity#GO:0140303;monoatomic anion channel activity#GO:0005253;channel activity#GO:0015267;chloride channel activity#GO:0005254;monoatomic anion transmembrane transporter activity#GO:0008509;transporter activity#GO:0005215;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;molecular carrier activity#GO:0140104;gated channel activity#GO:0022836 macromolecule localization#GO:0033036;cellular process#GO:0009987;monoatomic anion transmembrane transport#GO:0098656;lipid transport#GO:0006869;monoatomic ion transmembrane transport#GO:0034220;phospholipid transport#GO:0015914;membrane organization#GO:0061024;phospholipid translocation#GO:0045332;biological regulation#GO:0065007;chloride transport#GO:0006821;transport#GO:0006810;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;regulation of membrane lipid distribution#GO:0097035;cellular component organization#GO:0016043;monoatomic anion transport#GO:0006820;organophosphate ester transport#GO:0015748;lipid translocation#GO:0034204;lipid localization#GO:0010876;transmembrane transport#GO:0055085;localization#GO:0051179;chloride transmembrane transport#GO:1902476;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 ion channel#PC00133;transporter#PC00227 HUMAN|HGNC=27263|UniProtKB=Q5T7N3 Q5T7N3 KANK4 PTHR24168:SF24 KN MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING KN MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 4 negative regulation of protein-containing complex assembly#GO:0031333;regulation of biological quality#GO:0065008;negative regulation of cytoskeleton organization#GO:0051494;negative regulation of protein polymerization#GO:0032272;regulation of actin filament length#GO:0030832;negative regulation of actin filament polymerization#GO:0030837;regulation of cellular component biogenesis#GO:0044087;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;regulation of protein polymerization#GO:0032271;negative regulation of supramolecular fiber organization#GO:1902904;regulation of cellular process#GO:0050794;regulation of cellular component size#GO:0032535;regulation of supramolecular fiber organization#GO:1902903;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;negative regulation of biological process#GO:0048519;negative regulation of cellular component organization#GO:0051129;cellular component organization#GO:0016043;regulation of protein-containing complex assembly#GO:0043254;negative regulation of organelle organization#GO:0010639;cellular component organization or biogenesis#GO:0071840;regulation of anatomical structure size#GO:0090066;negative regulation of cellular process#GO:0048523;regulation of actin filament-based process#GO:0032970;regulation of actin polymerization or depolymerization#GO:0008064;biological regulation#GO:0065007;regulation of actin cytoskeleton organization#GO:0032956;regulation of actin filament polymerization#GO:0030833;cellular process#GO:0009987;regulation of actin filament organization#GO:0110053 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737 non-motor actin binding protein#PC00165 HUMAN|HGNC=14250|UniProtKB=Q9H306 Q9H306 MMP27 PTHR10201:SF115 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE-27 hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 catabolic process#GO:0009056;cellular process#GO:0009987;cellular component organization#GO:0016043;external encapsulating structure organization#GO:0045229;cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;metabolic process#GO:0008152;extracellular structure organization#GO:0043062 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 metalloprotease#PC00153 Alzheimer disease-presenilin pathway#P00004>Matrix metalloprotease#P00130 HUMAN|HGNC=37241|UniProtKB=B2RV13 B2RV13 CFAP97D1 PTHR33768:SF5 MIP11318P SPERM AXONEMAL MAINTENANCE PROTEIN CFAP97D1 HUMAN|HGNC=33808|UniProtKB=Q6ZVW7 Q6ZVW7 IL17REL PTHR15583:SF10 INTERLEUKIN-17 RECEPTOR INTERLEUKIN-17 RECEPTOR E-LIKE PROTEIN transmembrane signaling receptor activity#GO:0004888;cytokine receptor activity#GO:0004896;signaling receptor activity#GO:0038023;immune receptor activity#GO:0140375;molecular transducer activity#GO:0060089 positive regulation of multicellular organismal process#GO:0051240;cellular response to stimulus#GO:0051716;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;positive regulation of cytokine production#GO:0001819;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;signaling#GO:0023052;cytokine-mediated signaling pathway#GO:0019221;positive regulation of biosynthetic process#GO:0009891;cell communication#GO:0007154;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;response to peptide#GO:1901652;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cytokine production#GO:0001817;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165;response to chemical#GO:0042221;positive regulation of macromolecule metabolic process#GO:0010604;response to cytokine#GO:0034097;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;cell surface receptor signaling pathway#GO:0007166;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of gene expression#GO:0010628 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=10926|UniProtKB=O15375 O15375 SLC16A5 PTHR11360:SF21 MONOCARBOXYLATE TRANSPORTER MONOCARBOXYLATE TRANSPORTER 6 carboxylic acid transmembrane transporter activity#GO:0046943;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monocarboxylic acid transmembrane transporter activity#GO:0008028 plasma membrane#GO:0005886;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;basal plasma membrane#GO:0009925;cell periphery#GO:0071944;basolateral plasma membrane#GO:0016323;basal part of cell#GO:0045178;membrane#GO:0016020 transporter#PC00227 HUMAN|HGNC=921|UniProtKB=Q9P2W7 Q9P2W7 B3GAT1 PTHR10896:SF21 GALACTOSYLGALACTOSYLXYLOSYLPROTEIN 3-BETA-GLUCURONOSYLTRANSFERASE BETA-1,3-GLUCURONYLTRANSFERASE GALACTOSYLGALACTOSYLXYLOSYLPROTEIN 3-BETA-GLUCURONOSYLTRANSFERASE 1 UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740;glucuronosyltransferase activity#GO:0015020 primary metabolic process#GO:0044238;carbohydrate metabolic process#GO:0005975;protein metabolic process#GO:0019538;glycoprotein biosynthetic process#GO:0009101;chondroitin sulfate proteoglycan metabolic process#GO:0050654;protein O-linked glycosylation#GO:0006493;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;chondroitin sulfate proteoglycan biosynthetic process#GO:0050650;biosynthetic process#GO:0009058;proteoglycan biosynthetic process#GO:0030166;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;proteoglycan metabolic process#GO:0006029 Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane#GO:0016020;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 glycosyltransferase#PC00111 HUMAN|HGNC=3530|UniProtKB=P00748 P00748 F12 PTHR24264:SF46 TRYPSIN-RELATED COAGULATION FACTOR XII catalytic activity#GO:0003824;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;serine-type peptidase activity#GO:0008236;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787 metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;blood coagulation#GO:0007596;response to stress#GO:0006950;response to wounding#GO:0009611;protein processing#GO:0016485;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;coagulation#GO:0050817;multicellular organismal process#GO:0032501;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;biological regulation#GO:0065007;proteolysis#GO:0006508;protein metabolic process#GO:0019538;wound healing#GO:0042060;regulation of biological quality#GO:0065008;hemostasis#GO:0007599;primary metabolic process#GO:0044238;zymogen activation#GO:0031638;regulation of body fluid levels#GO:0050878;response to stimulus#GO:0050896 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;rough endoplasmic reticulum#GO:0005791;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;extracellular region#GO:0005576;endoplasmic reticulum#GO:0005783 serine protease#PC00203;protease#PC00190 Blood coagulation#P00011>FXIIa#P00441;Blood coagulation#P00011>FXII#P00442 HUMAN|HGNC=16857|UniProtKB=Q9BXK1 Q9BXK1 KLF16 PTHR23235:SF71 KRUEPPEL-LIKE TRANSCRIPTION FACTOR KRUEPPEL-LIKE FACTOR 16 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=7399|UniProtKB=P13640 P13640 MT1G PTHR23299:SF22 METALLOTHIONEIN METALLOTHIONEIN-1G small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;metal ion binding#GO:0046872;cation binding#GO:0043169 response to stimulus#GO:0050896;response to toxic substance#GO:0009636;homeostatic process#GO:0042592;intracellular monoatomic ion homeostasis#GO:0006873;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;inorganic ion homeostasis#GO:0098771;response to chemical#GO:0042221;detoxification#GO:0098754;monoatomic ion homeostasis#GO:0050801;detoxification of inorganic compound#GO:0061687;response to stress#GO:0006950;cellular process#GO:0009987;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;response to cadmium ion#GO:0046686;response to metal ion#GO:0010038;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;intracellular monoatomic cation homeostasis#GO:0030003 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 defense/immunity protein#PC00090 HUMAN|HGNC=29277|UniProtKB=Q8N1G0 Q8N1G0 ZNF687 PTHR47222:SF2 ZINC FINGER PROTEIN 532-RELATED ZINC FINGER PROTEIN 687 HUMAN|HGNC=6184|UniProtKB=Q9NZM3 Q9NZM3 ITSN2 PTHR11216:SF29 EH DOMAIN INTERSECTIN-2 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 synaptic vesicle endocytosis#GO:0048488;clathrin-dependent endocytosis#GO:0072583;endocytosis#GO:0006897;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;synaptic vesicle recycling#GO:0036465;intracellular transport#GO:0046907;synaptic vesicle cycle#GO:0099504;transport#GO:0006810;establishment of localization#GO:0051234;import into cell#GO:0098657;vesicle-mediated transport in synapse#GO:0099003;endosomal transport#GO:0016197;receptor-mediated endocytosis#GO:0006898 organelle#GO:0043226;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular vesicle#GO:0097708;membrane#GO:0016020;vesicle#GO:0031982;cell periphery#GO:0071944;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 membrane traffic protein#PC00150 HUMAN|HGNC=8759|UniProtKB=P20941 P20941 PDC PTHR46052:SF3 PHOSDUCIN-LIKE PROTEIN PHOSDUCIN membrane-bounded organelle#GO:0043227;non-motile cilium#GO:0097730;cilium#GO:0005929;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;photoreceptor outer segment#GO:0001750;organelle#GO:0043226;cellular anatomical structure#GO:0110165;neuron projection#GO:0043005;photoreceptor cell cilium#GO:0097733;9+0 non-motile cilium#GO:0097731 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Phosducin#P00758 HUMAN|HGNC=27963|UniProtKB=A1A519 A1A519 FAM170A PTHR33517:SF3 PROTEIN FAM170B-RELATED PROTEIN FAM170A fertilization#GO:0009566;reproductive process#GO:0022414;sexual reproduction#GO:0019953 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=18235|UniProtKB=Q9H201 Q9H201 EPN3 PTHR12276:SF16 EPSIN/ENT-RELATED EPSIN-3 binding#GO:0005488;phospholipid binding#GO:0005543;clathrin binding#GO:0030276;lipid binding#GO:0008289;protein binding#GO:0005515 vesicle-mediated transport#GO:0016192;endocytosis#GO:0006897;cellular process#GO:0009987;clathrin-dependent endocytosis#GO:0072583;import into cell#GO:0098657;establishment of localization#GO:0051234;localization#GO:0051179;receptor-mediated endocytosis#GO:0006898;transport#GO:0006810 organelle#GO:0043226;clathrin coat#GO:0030118;cellular anatomical structure#GO:0110165;coated vesicle membrane#GO:0030662;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;vesicle#GO:0031982;coated membrane#GO:0048475;membrane coat#GO:0030117;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;coated vesicle#GO:0030135;intracellular organelle#GO:0043229;endosome#GO:0005768;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;vesicle coat#GO:0030120;cytoplasm#GO:0005737;vesicle membrane#GO:0012506;membrane#GO:0016020;cell periphery#GO:0071944;clathrin-coated vesicle membrane#GO:0030665;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;clathrin vesicle coat#GO:0030125;clathrin-coated vesicle#GO:0030136 membrane trafficking regulatory protein#PC00151;membrane traffic protein#PC00150 HUMAN|HGNC=1953|UniProtKB=P08173 P08173 CHRM4 PTHR24247:SF180 5-HYDROXYTRYPTAMINE RECEPTOR MUSCARINIC ACETYLCHOLINE RECEPTOR M4 G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;neurotransmitter receptor activity#GO:0030594;G protein-coupled amine receptor activity#GO:0008227;molecular transducer activity#GO:0060089;acetylcholine receptor activity#GO:0015464;transmembrane signaling receptor activity#GO:0004888;postsynaptic neurotransmitter receptor activity#GO:0098960 regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;chemical synaptic transmission#GO:0007268;signaling#GO:0023052;anterograde trans-synaptic signaling#GO:0098916;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;response to oxygen-containing compound#GO:1901700;G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887;trans-synaptic signaling#GO:0099537;response to nitrogen compound#GO:1901698;cell communication#GO:0007154;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;cellular process#GO:0009987;synaptic signaling#GO:0099536;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;response to chemical#GO:0042221;acetylcholine receptor signaling pathway#GO:0095500;cellular response to nitrogen compound#GO:1901699;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway#GO:0007193 dendritic tree#GO:0097447;dendrite#GO:0030425;cell junction#GO:0030054;cell periphery#GO:0071944;neuron projection#GO:0043005;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;synapse#GO:0045202 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>mAChR2/4#P01077;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GqPCR#P00730;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GoPCR#P00725;Alzheimer disease-amyloid secretase pathway#P00003>Muscarinic acetylcholine receptors#P00083 HUMAN|HGNC=30757|UniProtKB=Q9Y2K9 Q9Y2K9 STXBP5L PTHR10241:SF19 LETHAL 2 GIANT LARVAE PROTEIN SYNTAXIN-BINDING PROTEIN 5-LIKE binding#GO:0005488;protein binding#GO:0005515;enzyme regulator activity#GO:0030234;syntaxin binding#GO:0019905;molecular function activator activity#GO:0140677;enzyme activator activity#GO:0008047;SNARE binding#GO:0000149;myosin binding#GO:0017022;cytoskeletal protein binding#GO:0008092;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;molecular function regulator activity#GO:0098772 Golgi vesicle transport#GO:0048193;transport#GO:0006810;localization within membrane#GO:0051668;post-Golgi vesicle-mediated transport#GO:0006892;exocytosis#GO:0006887;secretion by cell#GO:0032940;vesicle-mediated transport to the plasma membrane#GO:0098876;establishment of localization#GO:0051234;secretion#GO:0046903;cellular localization#GO:0051641;localization#GO:0051179;cellular process#GO:0009987;export from cell#GO:0140352;vesicle-mediated transport#GO:0016192;Golgi to plasma membrane transport#GO:0006893 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=15108|UniProtKB=Q8NGT2 Q8NGT2 OR13J1 PTHR26453:SF38 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 13J1 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 system process#GO:0003008;nervous system process#GO:0050877;sensory perception#GO:0007600;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;response to chemical#GO:0042221;response to stimulus#GO:0050896;detection of chemical stimulus#GO:0009593;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=18505|UniProtKB=Q68DV7 Q68DV7 RNF43 PTHR16200:SF2 RING ZINC FINGER E3 UBIQUITIN-PROTEIN LIGASE RNF43 G protein-coupled receptor binding#GO:0001664;frizzled binding#GO:0005109;transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;signaling receptor binding#GO:0005102;binding#GO:0005488;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;protein binding#GO:0005515 regulation of Wnt signaling pathway#GO:0030111;regulation of cell communication#GO:0010646;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;modification-dependent protein catabolic process#GO:0019941;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;primary metabolic process#GO:0044238;negative regulation of cell communication#GO:0010648;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of signal transduction#GO:0009968;negative regulation of response to stimulus#GO:0048585;negative regulation of Wnt signaling pathway#GO:0030178;cellular process#GO:0009987;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;regulation of response to stimulus#GO:0048583;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;negative regulation of cellular process#GO:0048523 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=14360|UniProtKB=P78415 P78415 IRX3 PTHR11211:SF14 IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX-3 double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;multicellular organism development#GO:0007275;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;neuron differentiation#GO:0030182;developmental process#GO:0032502;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;nervous system development#GO:0007399;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=119|UniProtKB=Q15067 Q15067 ACOX1 PTHR10909:SF397 ELECTRON TRANSPORT OXIDOREDUCTASE PEROXISOMAL ACYL-COENZYME A OXIDASE 1 carboxylic acid binding#GO:0031406;flavin adenine dinucleotide binding#GO:0050660;anion binding#GO:0043168;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265;organic acid binding#GO:0043177;fatty acid binding#GO:0005504;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;lipid binding#GO:0008289;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;heterocyclic compound binding#GO:1901363;nucleotide binding#GO:0000166 cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;lipid catabolic process#GO:0016042;monocarboxylic acid catabolic process#GO:0072329;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;fatty acid beta-oxidation#GO:0006635;lipid metabolic process#GO:0006629;fatty acid oxidation#GO:0019395;lipid modification#GO:0030258;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;monocarboxylic acid metabolic process#GO:0032787;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;small molecule catabolic process#GO:0044282;very long-chain fatty acid metabolic process#GO:0000038;oxoacid metabolic process#GO:0043436;lipid oxidation#GO:0034440;fatty acid catabolic process#GO:0009062 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;peroxisome#GO:0005777;microbody#GO:0042579;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HUMAN|HGNC=6153|UniProtKB=P05556 P05556 ITGB1 PTHR10082:SF28 INTEGRIN BETA SUBUNIT INTEGRIN BETA-1 cell adhesion molecule binding#GO:0050839;cell adhesion mediator activity#GO:0098631;integrin binding#GO:0005178;cytokine binding#GO:0019955;laminin binding#GO:0043236;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;binding#GO:0005488;kinase binding#GO:0019900;signaling receptor binding#GO:0005102;collagen binding#GO:0005518;protein-containing complex binding#GO:0044877;extracellular matrix binding#GO:0050840;protein binding#GO:0005515 cell communication#GO:0007154;cell-substrate adhesion#GO:0031589;cell adhesion#GO:0007155;cell-matrix adhesion#GO:0007160;response to stimulus#GO:0050896;cell motility#GO:0048870;regulation of cellular process#GO:0050794;signaling#GO:0023052;integrin-mediated signaling pathway#GO:0007229;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell adhesion mediated by integrin#GO:0033627;cell surface receptor signaling pathway#GO:0007166;cell migration#GO:0016477;biological regulation#GO:0065007;cell-cell adhesion#GO:0098609;signal transduction#GO:0007165;cellular process#GO:0009987 signaling receptor complex#GO:0043235;cell junction#GO:0030054;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cell surface#GO:0009986;anchoring junction#GO:0070161;integrin complex#GO:0008305;protein complex involved in cell adhesion#GO:0098636;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;focal adhesion#GO:0005925;cell-substrate junction#GO:0030055;synapse#GO:0045202;cellular anatomical structure#GO:0110165 integrin#PC00126 CCKR signaling map#P06959>ITGB1#P07113;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Integrin#P00853;Integrin signalling pathway#P00034>Integrin beta#P00931;CCKR signaling map#P06959>ITGB1#G06984;CCKR signaling map#P06959>ITGB1#G07277;Gonadotropin-releasing hormone receptor pathway#P06664>alpha-beta integrin dimer#P06820 HUMAN|HGNC=28107|UniProtKB=Q96CD2 Q96CD2 PPCDC PTHR14359:SF6 HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE lyase activity#GO:0016829;ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265;anion binding#GO:0043168;small molecule binding#GO:0036094;binding#GO:0005488;heterocyclic compound binding#GO:1901363;nucleotide binding#GO:0000166;carboxy-lyase activity#GO:0016831;carbohydrate derivative binding#GO:0097367;catalytic activity#GO:0003824;carbon-carbon lyase activity#GO:0016830;ribonucleotide binding#GO:0032553 purine-containing compound biosynthetic process#GO:0072522;organophosphate biosynthetic process#GO:0090407;purine-containing compound metabolic process#GO:0072521;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleobase-containing small molecule metabolic process#GO:0055086;nucleoside phosphate biosynthetic process#GO:1901293;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;sulfur compound metabolic process#GO:0006790;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058 catalytic complex#GO:1902494;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 metabolite interconversion enzyme#PC00262;decarboxylase#PC00089 Coenzyme A biosynthesis#P02736>Pantothenoylcysteine decarboxylase#P02883;Coenzyme A biosynthesis#P02736>Pantothenate cysteine ligase#P02882 HUMAN|HGNC=7109|UniProtKB=Q9UL63 Q9UL63 MKLN1 PTHR15526:SF5 MUSKELIN MUSKELIN intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=29177|UniProtKB=Q7Z3U7 Q7Z3U7 MON2 PTHR10663:SF333 GUANYL-NUCLEOTIDE EXCHANGE FACTOR PROTEIN MON2 HOMOLOG protein localization to vacuole#GO:0072665;protein transport#GO:0015031;cellular localization#GO:0051641;localization#GO:0051179;cytosolic transport#GO:0016482;protein targeting#GO:0006605;protein localization to organelle#GO:0033365;establishment of protein localization to vacuole#GO:0072666;intracellular protein transport#GO:0006886;transport#GO:0006810;vacuolar transport#GO:0007034;intracellular transport#GO:0046907;endosomal transport#GO:0016197;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;protein targeting to vacuole#GO:0006623;retrograde transport, endosome to Golgi#GO:0042147;macromolecule localization#GO:0033036;vesicle-mediated transport#GO:0016192 vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;endosome membrane#GO:0010008;endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;vesicle membrane#GO:0012506;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;early endosome membrane#GO:0031901;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090 guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=16528|UniProtKB=Q9UK85 Q9UK85 DKKL1 PTHR12113:SF7 DICKKOPF3-LIKE 3 DICKKOPF-LIKE PROTEIN 1 signaling receptor inhibitor activity#GO:0030547;molecular function regulator activity#GO:0098772;molecular function inhibitor activity#GO:0140678;protein binding#GO:0005515;binding#GO:0005488;signaling receptor regulator activity#GO:0030545 negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of canonical Wnt signaling pathway#GO:0060828;negative regulation of response to stimulus#GO:0048585;negative regulation of Wnt signaling pathway#GO:0030178;negative regulation of signal transduction#GO:0009968;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of canonical Wnt signaling pathway#GO:0090090;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of Wnt signaling pathway#GO:0030111;regulation of cell communication#GO:0010646 acrosomal vesicle#GO:0001669;extracellular region#GO:0005576;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;secretory vesicle#GO:0099503;intracellular vesicle#GO:0097708;vesicle#GO:0031982;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 membrane trafficking regulatory protein#PC00151;membrane traffic protein#PC00150 HUMAN|HGNC=14307|UniProtKB=Q9BTT6 Q9BTT6 LRRC1 PTHR48051:SF10 FAMILY NOT NAMED LEUCINE-RICH REPEAT-CONTAINING PROTEIN 1 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=6533|UniProtKB=O43679 O43679 LDB2 PTHR10378:SF8 LIM DOMAIN-BINDING PROTEIN LIM DOMAIN-BINDING PROTEIN 2 transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;animal gross anatomical part developmental process#GO:0160108;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of macromolecule biosynthetic process#GO:0010558;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604;nervous system development#GO:0007399;positive regulation of transcription by RNA polymerase II#GO:0045944;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;multicellular organism development#GO:0007275;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biosynthetic process#GO:0009891;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;negative regulation of transcription by RNA polymerase II#GO:0000122;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226 transcription cofactor#PC00217;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=29557|UniProtKB=Q0ZGT2 Q0ZGT2 NEXN PTHR10075:SF52 BASIGIN RELATED NEXILIN supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;Z disc#GO:0030018;contractile muscle fiber#GO:0043292;membraneless organelle#GO:0043228;cell junction#GO:0030054;sarcomere#GO:0030017;I band#GO:0031674;cellular anatomical structure#GO:0110165;organelle#GO:0043226;focal adhesion#GO:0005925;cell-substrate junction#GO:0030055;myofibril#GO:0030016;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;supramolecular fiber#GO:0099512;intracellular organelle#GO:0043229 cell adhesion molecule#PC00069 HUMAN|HGNC=21595|UniProtKB=Q9Y6P5 Q9Y6P5 SESN1 PTHR12474:SF3 P53 REGULATED PA26 NUCLEAR PROTEIN SESTRIN SESTRIN-1 oxidoreductase activity#GO:0016491;amino acid binding#GO:0016597;catalytic activity#GO:0003824;cation binding#GO:0043169;oxidoreductase activity, acting on peroxide as acceptor#GO:0016684;ion binding#GO:0043167;carboxylic acid binding#GO:0031406;anion binding#GO:0043168;binding#GO:0005488;small molecule binding#GO:0036094;organic acid binding#GO:0043177 cellular response to nitrogen compound#GO:1901699;negative regulation of response to stimulus#GO:0048585;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;response to nutrient levels#GO:0031667;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;positive regulation of catabolic process#GO:0009896;regulation of TORC1 signaling#GO:1903432;regulation of catabolic process#GO:0009894;cellular response to starvation#GO:0009267;negative regulation of cellular process#GO:0048523;cellular response to nutrient levels#GO:0031669;regulation of response to stimulus#GO:0048583;negative regulation of TOR signaling#GO:0032007;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;response to starvation#GO:0042594;cellular response to stimulus#GO:0051716;response to nitrogen compound#GO:1901698;response to chemical#GO:0042221;cellular response to amino acid starvation#GO:0034198;negative regulation of signal transduction#GO:0009968;positive regulation of autophagy#GO:0010508;response to stress#GO:0006950;cellular response to oxygen-containing compound#GO:1901701;response to acid chemical#GO:0001101;positive regulation of biological process#GO:0048518;regulation of TOR signaling#GO:0032006;cellular process#GO:0009987;regulation of macroautophagy#GO:0016241;negative regulation of TORC1 signaling#GO:1904262;cellular response to amino acid stimulus#GO:0071230;response to stimulus#GO:0050896;positive regulation of macroautophagy#GO:0016239;negative regulation of biological process#GO:0048519;regulation of autophagy#GO:0010506;regulation of biological process#GO:0050789;positive regulation of metabolic process#GO:0009893;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;cellular response to chemical stimulus#GO:0070887;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;response to oxygen-containing compound#GO:1901700;cellular response to stress#GO:0033554;regulation of signaling#GO:0023051 oxidoreductase#PC00176;peroxidase#PC00180 HUMAN|HGNC=26253|UniProtKB=Q5SVZ6 Q5SVZ6 ZMYM1 PTHR45736:SF4 ZINC FINGER MYM-TYPE PROTEIN ZINC FINGER MYM-TYPE PROTEIN 1 zinc finger transcription factor#PC00244;DNA-binding transcription factor#PC00218 HUMAN|HGNC=35464|UniProtKB=A6NIY4 A6NIY4 SPDYE5 PTHR31156:SF15 WBSCR19-LIKE PROTEIN SPEEDY PROTEIN E10-RELATED HUMAN|HGNC=17273|UniProtKB=Q9NS87 Q9NS87 KIF15 PTHR24115:SF1004 KINESIN-RELATED KINESIN-LIKE PROTEIN KIF15 protein binding#GO:0005515;ATP-dependent activity#GO:0140657;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;cytoskeletal motor activity#GO:0003774;hydrolase activity, acting on acid anhydrides#GO:0016817;cytoskeletal protein binding#GO:0008092;microtubule motor activity#GO:0003777;ATP hydrolysis activity#GO:0016887;hydrolase activity#GO:0016787;polypeptide conformation or assembly isomerase activity#GO:0120544;microtubule binding#GO:0008017;isomerase activity#GO:0016853;ribonucleoside triphosphate phosphatase activity#GO:0017111;macromolecular conformation isomerase activity#GO:0120543;tubulin binding#GO:0015631;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462 microtubule-based process#GO:0007017;microtubule-based movement#GO:0007018;cellular process#GO:0009987 supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;microtubule cytoskeleton#GO:0015630 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=3133|UniProtKB=Q15125 Q15125 EBP PTHR14207:SF8 STEROL ISOMERASE 3-BETA-HYDROXYSTEROID-DELTA(8),DELTA(7)-ISOMERASE catalytic activity#GO:0003824;intramolecular oxidoreductase activity#GO:0016860;isomerase activity#GO:0016853 primary metabolic process#GO:0044238;small molecule metabolic process#GO:0044281;secondary alcohol metabolic process#GO:1902652;alcohol biosynthetic process#GO:0046165;cellular process#GO:0009987;cholesterol biosynthetic process#GO:0006695;lipid biosynthetic process#GO:0008610;steroid metabolic process#GO:0008202;sterol biosynthetic process#GO:0016126;biosynthetic process#GO:0009058;metabolic process#GO:0008152;alcohol metabolic process#GO:0006066;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;cholesterol metabolic process#GO:0008203;secondary alcohol biosynthetic process#GO:1902653;steroid biosynthetic process#GO:0006694;sterol metabolic process#GO:0016125 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 isomerase#PC00135 HUMAN|HGNC=14499|UniProtKB=Q9Y2R9 Q9Y2R9 MRPS7 PTHR11205:SF19 RIBOSOMAL PROTEIN S7 SMALL RIBOSOMAL SUBUNIT PROTEIN US7M structural molecule activity#GO:0005198;RNA binding#GO:0003723;binding#GO:0005488;structural constituent of ribosome#GO:0003735;rRNA binding#GO:0019843;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729 metabolic process#GO:0008152;translation#GO:0006412;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;biosynthetic process#GO:0009058 ribosome#GO:0005840;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membraneless organelle#GO:0043232 translational protein#PC00263;ribosomal protein#PC00202 HUMAN|HGNC=25564|UniProtKB=Q9NVJ2 Q9NVJ2 ARL8B PTHR45732:SF13 ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8 ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8B axo-dendritic transport#GO:0008088;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;cytoskeleton-dependent intracellular transport#GO:0030705;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;transport#GO:0006810;vacuolar transport#GO:0007034;transport along microtubule#GO:0010970;establishment of localization#GO:0051234;microtubule-based process#GO:0007017;endosomal transport#GO:0016197;microtubule-based movement#GO:0007018;lysosomal transport#GO:0007041;axonal transport#GO:0098930;microtubule-based transport#GO:0099111;cellular localization#GO:0051641;localization#GO:0051179;anterograde axonal transport#GO:0008089 vacuole#GO:0005773;cytoplasm#GO:0005737;lysosomal membrane#GO:0005765;membrane#GO:0016020;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;lytic vacuole#GO:0000323;vacuolar membrane#GO:0005774;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;lysosome#GO:0005764;lytic vacuole membrane#GO:0098852;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=30305|UniProtKB=Q13156 Q13156 RPA4 PTHR13989:SF53 REPLICATION PROTEIN A-RELATED REPLICATION PROTEIN A 30 KDA SUBUNIT single-stranded DNA binding#GO:0003697;binding#GO:0005488;nucleic acid binding#GO:0003676;telomeric repeat DNA binding#GO:0042162;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677 nucleotide-excision repair#GO:0006289;nucleobase-containing compound metabolic process#GO:0006139;response to stress#GO:0006950;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;double-strand break repair#GO:0006302;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA damage response#GO:0006974;DNA recombination#GO:0006310;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;DNA replication#GO:0006260;cellular response to stimulus#GO:0051716;double-strand break repair via homologous recombination#GO:0000724;recombinational repair#GO:0000725;cellular response to stress#GO:0033554 intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687;membrane-bounded organelle#GO:0043227;site of DNA damage#GO:0090734;nuclear replication fork#GO:0043596;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;protein-DNA complex#GO:0032993;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;organelle lumen#GO:0043233;replication fork#GO:0005657;replisome#GO:0030894;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;protein-containing complex#GO:0032991;chromosome, telomeric region#GO:0000781;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;site of double-strand break#GO:0035861;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 HUMAN|HGNC=27031|UniProtKB=Q8WVE6 Q8WVE6 TMEM171 PTHR31617:SF0 TRANSMEMBRANE PROTEIN 171 TRANSMEMBRANE PROTEIN 171 HUMAN|HGNC=19293|UniProtKB=P59282 P59282 TPPP2 PTHR12932:SF21 P25 ALPHA-RELATED TUBULIN POLYMERIZATION-PROMOTING PROTEIN FAMILY MEMBER 2 cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;binding#GO:0005488;protein binding#GO:0005515 regulation of cellular component biogenesis#GO:0044087;regulation of cellular process#GO:0050794;regulation of protein polymerization#GO:0032271;regulation of cellular component organization#GO:0051128;protein polymerization#GO:0051258;regulation of biological process#GO:0050789;protein-containing complex assembly#GO:0065003;regulation of protein-containing complex assembly#GO:0043254;cellular component organization#GO:0016043;supramolecular fiber organization#GO:0097435;microtubule cytoskeleton organization#GO:0000226;microtubule bundle formation#GO:0001578;positive regulation of cellular component organization#GO:0051130;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;positive regulation of cellular component biogenesis#GO:0044089;cellular component assembly#GO:0022607;positive regulation of protein polymerization#GO:0032273;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;microtubule polymerization or depolymerization#GO:0031109;microtubule polymerization#GO:0046785;protein-containing complex organization#GO:0043933;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840 microtubule#GO:0005874;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;organelle#GO:0043226;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630 non-motor microtubule binding protein#PC00166 HUMAN|HGNC=26899|UniProtKB=Q6ZXV5 Q6ZXV5 TMTC3 PTHR44395:SF1 FAMILY NOT NAMED PROTEIN O-MANNOSYL-TRANSFERASE TMTC3 HUMAN|HGNC=1985|UniProtKB=O14578 O14578 CIT PTHR22988:SF71 MYOTONIC DYSTROPHY S/T KINASE-RELATED CITRON RHO-INTERACTING KINASE transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 regulation of cellular component organization#GO:0051128;mitotic cell cycle#GO:0000278;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794;actin cytoskeleton organization#GO:0030036;actomyosin structure organization#GO:0031032;cell cycle#GO:0007049;cellular component organization#GO:0016043;regulation of cellular component size#GO:0032535;regulation of biological process#GO:0050789;regulation of supramolecular fiber organization#GO:1902903;regulation of organelle organization#GO:0033043;regulation of biological quality#GO:0065008;regulation of actin filament length#GO:0030832;actin filament-based process#GO:0030029;biological regulation#GO:0065007;regulation of actin polymerization or depolymerization#GO:0008064;cytoskeleton organization#GO:0007010;regulation of actin cytoskeleton organization#GO:0032956;organelle organization#GO:0006996;cellular process#GO:0009987;regulation of actin filament organization#GO:0110053;cellular component organization or biogenesis#GO:0071840;regulation of anatomical structure size#GO:0090066;regulation of actin filament-based process#GO:0032970 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=9293|UniProtKB=Q9UQK1 Q9UQK1 PPP1R3C PTHR12307:SF15 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 3C phosphatase binding#GO:0019902;polysaccharide binding#GO:0030247;binding#GO:0005488;enzyme binding#GO:0019899;carbohydrate binding#GO:0030246;protein binding#GO:0005515;protein phosphatase binding#GO:0019903 regulation of polysaccharide biosynthetic process#GO:0032885;regulation of biosynthetic process#GO:0009889;regulation of carbohydrate metabolic process#GO:0006109;regulation of glycogen biosynthetic process#GO:0005979;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of carbohydrate biosynthetic process#GO:0043255;regulation of polysaccharide metabolic process#GO:0032881;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789 protein serine/threonine phosphatase complex#GO:0008287;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 phosphatase modulator#PC00184;protein-binding activity modulator#PC00095 HUMAN|HGNC=23601|UniProtKB=Q701N2 Q701N2 KRTAP5-5 PTHR23262:SF173 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 5-5 structural protein#PC00211 HUMAN|HGNC=11059|UniProtKB=Q9UPY5 Q9UPY5 SLC7A11 PTHR11785:SF323 AMINO ACID TRANSPORTER CYSTINE_GLUTAMATE TRANSPORTER carboxylic acid transmembrane transporter activity#GO:0046943;secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;antiporter activity#GO:0015297;amino acid transmembrane transporter activity#GO:0015171;L-amino acid transmembrane transporter activity#GO:0015179;acidic amino acid transmembrane transporter activity#GO:0015172;active transmembrane transporter activity#GO:0022804;dicarboxylic acid transmembrane transporter activity#GO:0005310;L-glutamate transmembrane transporter activity#GO:0005313 cellular process#GO:0009987;amino acid transport#GO:0006865;transport#GO:0006810;establishment of localization#GO:0051234;amino acid transmembrane transport#GO:0003333;transmembrane transport#GO:0055085;localization#GO:0051179 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227 HUMAN|HGNC=2895|UniProtKB=Q9UNE0 Q9UNE0 EDAR PTHR12120:SF9 TNFR-CYS DOMAIN-CONTAINING PROTEIN TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER EDAR molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 cell surface receptor signaling pathway#GO:0007166;cytokine-mediated signaling pathway#GO:0019221;response to peptide#GO:1901652;cell communication#GO:0007154;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;biological regulation#GO:0065007;signaling#GO:0023052;response to cytokine#GO:0034097;response to stimulus#GO:0050896;response to chemical#GO:0042221;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HUMAN|HGNC=19412|UniProtKB=O75800 O75800 ZMYND10 PTHR13244:SF7 ZINC FINGER MYND DOMAIN CONTAINING PROTEIN 10 ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 10 axonemal dynein complex assembly#GO:0070286;microtubule bundle formation#GO:0001578;inner dynein arm assembly#GO:0036159;organelle assembly#GO:0070925;cilium organization#GO:0044782;axoneme assembly#GO:0035082;microtubule cytoskeleton organization#GO:0000226;protein-containing complex assembly#GO:0065003;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cell projection organization#GO:0030030;plasma membrane bounded cell projection assembly#GO:0120031;microtubule-based process#GO:0007017;protein-containing complex organization#GO:0043933;motile cilium assembly#GO:0044458;cellular component organization or biogenesis#GO:0071840;outer dynein arm assembly#GO:0036158;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607 microtubule cytoskeleton#GO:0015630;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;centriolar satellite#GO:0034451;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;centrosome#GO:0005813;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=9590|UniProtKB=Q96BW5 Q96BW5 PTER PTHR10819:SF3 PHOSPHOTRIESTERASE-RELATED N-ACETYLTAURINE HYDROLASE esterase#PC00097;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=28380|UniProtKB=Q86VD7 Q86VD7 SLC25A42 PTHR24089:SF736 SOLUTE CARRIER FAMILY 25 MITOCHONDRIAL COENZYME A TRANSPORTER SLC25A42 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;nucleobase-containing compound transmembrane transporter activity#GO:0015932;organophosphate ester transmembrane transporter activity#GO:0015605 nucleobase-containing compound transport#GO:0015931;organophosphate ester transport#GO:0015748;cellular process#GO:0009987;nitrogen compound transport#GO:0071705;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;transport#GO:0006810 organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;membrane#GO:0016020;organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 secondary carrier transporter#PC00258;mitochondrial carrier protein#PC00158 HUMAN|HGNC=14826|UniProtKB=Q6IF99 Q6IF99 OR10K2 PTHR26451:SF876 G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN OLFACTORY RECEPTOR 10K2 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception#GO:0007600;nervous system process#GO:0050877;system process#GO:0003008;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;detection of chemical stimulus#GO:0009593;response to chemical#GO:0042221;response to stimulus#GO:0050896;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608 cellular anatomical structure#GO:0110165;membrane#GO:0016020 G-protein coupled receptor#PC00021 HUMAN|HGNC=4249|UniProtKB=O95749 O95749 GGPS1 PTHR12001:SF44 GERANYLGERANYL PYROPHOSPHATE SYNTHASE GERANYLGERANYL PYROPHOSPHATE SYNTHASE transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;prenyltransferase activity#GO:0004659 cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;isoprenoid biosynthetic process#GO:0008299;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;isoprenoid metabolic process#GO:0006720 metabolite interconversion enzyme#PC00262 Cholesterol biosynthesis#P00014>Dimethylallyl trans-transferase#P00490 HUMAN|HGNC=6378|UniProtKB=Q13241 Q13241 KLRD1 PTHR22800:SF260 C-TYPE LECTIN PROTEINS NATURAL KILLER CELLS ANTIGEN CD94 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;immune receptor activity#GO:0140375;transmembrane signaling receptor activity#GO:0004888 immune response-activating cell surface receptor signaling pathway#GO:0002429;positive regulation of natural killer cell mediated immunity#GO:0002717;regulation of response to biotic stimulus#GO:0002831;response to external biotic stimulus#GO:0043207;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;regulation of natural killer cell mediated immunity#GO:0002715;regulation of leukocyte mediated immunity#GO:0002703;innate immune response-activating signaling pathway#GO:0002758;regulation of leukocyte mediated cytotoxicity#GO:0001910;regulation of immune effector process#GO:0002697;positive regulation of lymphocyte mediated immunity#GO:0002708;cell communication#GO:0007154;regulation of defense response#GO:0031347;regulation of immune response#GO:0050776;response to other organism#GO:0051707;positive regulation of immune effector process#GO:0002699;immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007;regulation of natural killer cell mediated cytotoxicity#GO:0042269;positive regulation of response to stimulus#GO:0048584;positive regulation of innate immune response#GO:0045089;immune response#GO:0006955;positive regulation of cellular process#GO:0048522;positive regulation of natural killer cell mediated cytotoxicity#GO:0045954;activation of innate immune response#GO:0002218;defense response#GO:0006952;positive regulation of response to biotic stimulus#GO:0002833;response to external stimulus#GO:0009605;innate immune response#GO:0045087;regulation of innate immune response#GO:0045088;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;positive regulation of defense response#GO:0031349;regulation of response to stress#GO:0080134;positive regulation of leukocyte mediated immunity#GO:0002705;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;immune response-regulating signaling pathway#GO:0002764;natural killer cell mediated immunity#GO:0002228;regulation of biological process#GO:0050789;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;regulation of cell killing#GO:0031341;immune system process#GO:0002376;regulation of lymphocyte mediated immunity#GO:0002706;regulation of response to external stimulus#GO:0032101;defense response to other organism#GO:0098542;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;signal transduction#GO:0007165;defense response to symbiont#GO:0140546;response to stress#GO:0006950;positive regulation of immune system process#GO:0002684;response to biotic stimulus#GO:0009607;positive regulation of response to external stimulus#GO:0032103;immune response-activating signaling pathway#GO:0002757;immune effector process#GO:0002252;cell surface receptor signaling pathway#GO:0007166 plasma membrane#GO:0005886;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 defense/immunity protein#PC00090 HUMAN|HGNC=22935|UniProtKB=Q92797 Q92797 SYMPK PTHR15245:SF20 SYMPLEKIN-RELATED SYMPLEKIN intracellular organelle#GO:0043229;mRNA cleavage and polyadenylation specificity factor complex#GO:0005847;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;mRNA cleavage factor complex#GO:0005849;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=5358|UniProtKB=Q02556 Q02556 IRF8 PTHR11949:SF7 INTERFERON REGULATORY FACTOR INTERFERON REGULATORY FACTOR 8 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 winged helix/forkhead transcription factor#PC00246;DNA-binding transcription factor#PC00218 HUMAN|HGNC=1743|UniProtKB=Q99459 Q99459 CDC5L PTHR45885:SF6 CELL DIVISION CYCLE 5-LIKE PROTEIN CELL DIVISION CYCLE 5-LIKE PROTEIN RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;biosynthetic process#GO:0009058;regulation of RNA biosynthetic process#GO:2001141;nucleobase-containing compound metabolic process#GO:0006139;regulation of nucleobase-containing compound metabolic process#GO:0019219;RNA splicing, via transesterification reactions#GO:0000375;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;cellular process#GO:0009987;mRNA processing#GO:0006397;RNA processing#GO:0006396;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;regulation of biological process#GO:0050789;mRNA splicing, via spliceosome#GO:0000398;mRNA metabolic process#GO:0016071;regulation of transcription by RNA polymerase II#GO:0006357 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;spliceosomal complex#GO:0005681;membrane-bounded organelle#GO:0043227;Prp19 complex#GO:0000974;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904 HUMAN|HGNC=29549|UniProtKB=Q8N5J4 Q8N5J4 SPIC PTHR11849:SF17 ETS TRANSCRIPTION FACTOR SPI-C DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700 regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;cellular process#GO:0009987;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 winged helix/forkhead transcription factor#PC00246;DNA-binding transcription factor#PC00218 Interleukin signaling pathway#P00036>Ets#P00989 HUMAN|HGNC=17777|UniProtKB=O94941 O94941 UBOX5 PTHR13492:SF2 RING FINGER PROTEIN 37 RING FINGER PROTEIN 37 catalytic activity#GO:0003824;ubiquitin-like protein ligase binding#GO:0044389;transferase activity#GO:0016740;ubiquitin protein ligase binding#GO:0031625;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;enzyme binding#GO:0019899;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;binding#GO:0005488;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;protein binding#GO:0005515 post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;cellular process#GO:0009987;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=23696|UniProtKB=Q7Z3E1 Q7Z3E1 TIPARP PTHR45740:SF7 POLY [ADP-RIBOSE] POLYMERASE PROTEIN MONO-ADP-RIBOSYLTRANSFERASE TIPARP glycosyltransferase activity#GO:0016757;catalytic activity, acting on a protein#GO:0140096;NAD+ poly-ADP-ribosyltransferase activity#GO:0003950;transferase activity#GO:0016740;catalytic activity#GO:0003824;pentosyltransferase activity#GO:0016763 macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;post-translational protein modification#GO:0043687;protein modification process#GO:0036211;primary metabolic process#GO:0044238;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=53837|UniProtKB=P0DPQ3 P0DPQ3 PRR20G PTHR38819:SF1 PROLINE-RICH PROTEIN 20A-RELATED PROLINE-RICH PROTEIN 20A-RELATED HUMAN|HGNC=20461|UniProtKB=Q9Y5B8 Q9Y5B8 NME7 PTHR43109:SF2 NUCLEOSIDE DIPHOSPHATE KINASE 7 NUCLEOSIDE DIPHOSPHATE KINASE 7 microtubule cytoskeleton#GO:0015630;ciliary plasm#GO:0097014;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;centrosome#GO:0005813;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cytoplasmic microtubule#GO:0005881;cellular anatomical structure#GO:0110165;axonemal microtubule#GO:0005879;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;intracellular organelle#GO:0043229;cilium#GO:0005929;axoneme#GO:0005930;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;supramolecular fiber#GO:0099512 transferase#PC00220;kinase#PC00137 De novo purine biosynthesis#P02738>GDP kinase#P02891;De novo purine biosynthesis#P02738>dADP kinase#P02907 HUMAN|HGNC=5967|UniProtKB=Q14626 Q14626 IL11RA PTHR23036:SF29 CYTOKINE RECEPTOR INTERLEUKIN-11 RECEPTOR SUBUNIT ALPHA immune receptor activity#GO:0140375;cytokine binding#GO:0019955;signaling receptor activity#GO:0038023;cytokine receptor activity#GO:0004896;molecular transducer activity#GO:0060089;protein binding#GO:0005515;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888 cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of cellular process#GO:0048522;biological regulation#GO:0065007;response to chemical#GO:0042221;response to cytokine#GO:0034097;cell surface receptor signaling pathway#GO:0007166;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;positive regulation of cell population proliferation#GO:0008284;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cytokine-mediated signaling pathway#GO:0019221;response to peptide#GO:1901652;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane#GO:0016020;signaling receptor complex#GO:0043235;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 Interleukin signaling pathway#P00036>Receptor subunit alpha#P00992 HUMAN|HGNC=23575|UniProtKB=O75179 O75179 ANKRD17 PTHR23206:SF1 MASK PROTEIN ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 17 defense response#GO:0006952;response to external stimulus#GO:0009605;innate immune response#GO:0045087;immune system process#GO:0002376;response to other organism#GO:0051707;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;defense response to other organism#GO:0098542;response to stimulus#GO:0050896;immune response#GO:0006955;defense response to symbiont#GO:0140546;response to stress#GO:0006950;response to biotic stimulus#GO:0009607 nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 defense/immunity protein#PC00090 HUMAN|HGNC=20977|UniProtKB=Q96RI9 Q96RI9 TAAR9 PTHR24249:SF79 HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR TRACE AMINE-ASSOCIATED RECEPTOR 9 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HUMAN|HGNC=5623|UniProtKB=A0A0B4J1V6 A0A0B4J1V6 IGHV3-73 PTHR23266:SF333 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 3-73 binding#GO:0005488;antigen binding#GO:0003823 immune system process#GO:0002376;immune effector process#GO:0002252;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;immune response#GO:0006955;response to stimulus#GO:0050896;adaptive immune response#GO:0002250 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=15685|UniProtKB=O43505 O43505 B4GAT1 PTHR46420:SF1 BETA-1,4-GLUCURONYLTRANSFERASE 1 BETA-1,4-GLUCURONYLTRANSFERASE 1 glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194;transferase activity#GO:0016740;glucuronosyltransferase activity#GO:0015020;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;protein O-linked glycosylation via mannose#GO:0035269;glycoprotein metabolic process#GO:0009100;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein O-linked glycosylation#GO:0006493;carbohydrate derivative metabolic process#GO:1901135 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 transferase#PC00220 HUMAN|HGNC=16897|UniProtKB=P52758 P52758 RIDA PTHR11803:SF53 2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA 2-IMINOBUTANOATE_2-IMINOPROPANOATE DEAMINASE deaminase activity#GO:0019239;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity#GO:0016787;catalytic activity#GO:0003824 negative regulation of protein metabolic process#GO:0051248;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;nucleic acid catabolic process#GO:0141188;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;nucleobase-containing compound catabolic process#GO:0034655;RNA metabolic process#GO:0016070;RNA catabolic process#GO:0006401;negative regulation of translation#GO:0017148;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;cellular process#GO:0009987;regulation of protein metabolic process#GO:0051246;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;cytosol#GO:0005829 deaminase#PC00088;metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HUMAN|HGNC=23087|UniProtKB=Q8N370 Q8N370 SLC43A2 PTHR20766:SF2 LARGE NEUTRAL AMINO ACIDS TRANSPORTER SMALL SUBUNIT 4-LIKE ISOFORM X1 LARGE NEUTRAL AMINO ACIDS TRANSPORTER SMALL SUBUNIT 4 L-amino acid transmembrane transporter activity#GO:0015179;amino acid transmembrane transporter activity#GO:0015171;neutral L-amino acid transmembrane transporter activity#GO:0015175;carboxylic acid transmembrane transporter activity#GO:0046943;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 establishment of localization#GO:0051234;neutral amino acid transport#GO:0015804;localization#GO:0051179;transport#GO:0006810;amino acid transport#GO:0006865 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 HUMAN|HGNC=17298|UniProtKB=Q9HAW0 Q9HAW0 BRF2 PTHR11618:SF5 TRANSCRIPTION INITIATION FACTOR IIB-RELATED TRANSCRIPTION FACTOR IIIB 50 KDA SUBUNIT protein binding#GO:0005515;binding#GO:0005488;transcription factor binding#GO:0008134 RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;DNA-templated transcription#GO:0006351;RNA polymerase II preinitiation complex assembly#GO:0051123;RNA biosynthetic process#GO:0032774;DNA-templated transcription initiation#GO:0006352;protein-containing complex assembly#GO:0065003;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;protein-containing complex organization#GO:0043933;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;protein-DNA complex organization#GO:0071824;transcription by RNA polymerase II#GO:0006366;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;protein-DNA complex assembly#GO:0065004;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular component assembly#GO:0022607;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;transcription initiation at RNA polymerase II promoter#GO:0006367;cellular component biogenesis#GO:0044085 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;protein-DNA complex#GO:0032993;intracellular membrane-bounded organelle#GO:0043231 general transcription factor#PC00259 General transcription regulation#P00023>TFIIB#P00668;Transcription regulation by bZIP transcription factor#P00055>TFIIB#P01397 HUMAN|HGNC=30682|UniProtKB=Q8N3D4 Q8N3D4 EHBP1L1 PTHR23167:SF42 CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED EH DOMAIN-BINDING PROTEIN 1-LIKE PROTEIN 1 actin filament-based process#GO:0030029;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;cellular component organization or biogenesis#GO:0071840 scaffold/adaptor protein#PC00226 HUMAN|HGNC=19579|UniProtKB=A6NMU1 A6NMU1 OR52A4P PTHR26450:SF121 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 52A4 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=20076|UniProtKB=Q96K76 Q96K76 USP47 PTHR24006:SF702 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 47 catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;cysteine-type deubiquitinase activity#GO:0004843;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005 regulation of biological quality#GO:0065008;biological regulation#GO:0065007;regulation of protein stability#GO:0031647 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;cytosol#GO:0005829 cysteine protease#PC00081;protease#PC00190 HUMAN|HGNC=589|UniProtKB=Q9H1Y0 Q9H1Y0 ATG5 PTHR13040:SF2 AUTOPHAGY PROTEIN 5 AUTOPHAGY PROTEIN 5 aminoacyltransferase activity#GO:0016755;ubiquitin-like protein ligase activity#GO:0061659;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740 cellular component assembly#GO:0022607;macroautophagy#GO:0016236;response to nutrient levels#GO:0031667;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;response to stress#GO:0006950;autophagy#GO:0006914;cellular process#GO:0009987;autophagosome organization#GO:1905037;mitophagy#GO:0000423;cellular component organization or biogenesis#GO:0071840;autophagosome assembly#GO:0000045;cellular response to starvation#GO:0009267;metabolic process#GO:0008152;autophagy of mitochondrion#GO:0000422;cellular response to nutrient levels#GO:0031669;response to stimulus#GO:0050896;catabolic process#GO:0009056;piecemeal microautophagy of the nucleus#GO:0034727;response to starvation#GO:0042594;cellular component organization#GO:0016043;cellular response to stimulus#GO:0051716;vacuole organization#GO:0007033;process utilizing autophagic mechanism#GO:0061919;organelle assembly#GO:0070925;cellular response to stress#GO:0033554 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;vacuole#GO:0005773;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;autophagosome#GO:0005776;intracellular organelle#GO:0043229;transferase complex#GO:1990234;phagophore assembly site#GO:0000407;catalytic complex#GO:1902494 membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=9466|UniProtKB=Q14558 Q14558 PRPSAP1 PTHR10210:SF28 RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER PHOSPHORIBOSYL PYROPHOSPHATE SYNTHASE-ASSOCIATED PROTEIN 1 transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234 nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;organophosphate metabolic process#GO:0019637;ribose phosphate biosynthetic process#GO:0046390;nucleobase-containing small molecule metabolic process#GO:0055086;nucleoside phosphate biosynthetic process#GO:1901293;carbohydrate derivative biosynthetic process#GO:1901137;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;nucleotide metabolic process#GO:0009117;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;transferase complex#GO:1990234;transferase complex, transferring phosphorus-containing groups#GO:0061695 nucleotide kinase#PC00172;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=12758|UniProtKB=Q9NNW5 Q9NNW5 WDR6 PTHR14344:SF3 WD REPEAT PROTEIN TRNA (34-2'-O)-METHYLTRANSFERASE REGULATOR WDR6 enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;tRNA methylation#GO:0030488;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;RNA metabolic process#GO:0016070;RNA methylation#GO:0001510;methylation#GO:0032259;macromolecule modification#GO:0043412;macromolecule methylation#GO:0043414;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;RNA biosynthetic process#GO:0032774;tRNA modification#GO:0006400;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=25985|UniProtKB=Q5H8A4 Q5H8A4 PIGG PTHR23072:SF0 PHOSPHATIDYLINOSITOL GLYCAN-RELATED GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 2, CATALYTIC SUBUNIT transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, for other substituted phosphate groups#GO:0016780;catalytic activity#GO:0003824;transferase activity#GO:0016740 glycolipid biosynthetic process#GO:0009247;organophosphate biosynthetic process#GO:0090407;protein metabolic process#GO:0019538;phospholipid metabolic process#GO:0006644;glycerolipid metabolic process#GO:0046486;liposaccharide metabolic process#GO:1903509;GPI anchored protein biosynthesis#GO:0180046;glycolipid metabolic process#GO:0006664;phospholipid biosynthetic process#GO:0008654;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;GPI anchor metabolic process#GO:0006505;glycerophospholipid biosynthetic process#GO:0046474;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;biosynthetic process#GO:0009058;glycerophospholipid metabolic process#GO:0006650;GPI anchor biosynthetic process#GO:0006506;protein maturation#GO:0051604;gene expression#GO:0010467;lipid biosynthetic process#GO:0008610;carbohydrate derivative metabolic process#GO:1901135;glycerolipid biosynthetic process#GO:0045017;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637 nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;endoplasmic reticulum membrane#GO:0005789;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783 HUMAN|HGNC=14581|UniProtKB=Q9BXM7 Q9BXM7 PINK1 PTHR22972:SF7 SERINE/THREONINE PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE PINK1, MITOCHONDRIAL catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 catabolic process#GO:0009056;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of mitochondrial fission#GO:0090140;regulation of developmental process#GO:0050793;positive regulation of mitochondrial fission#GO:0090141;regulation of programmed cell death#GO:0043067;regulation of mitochondrion organization#GO:0010821;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;positive regulation of organelle organization#GO:0010638;process utilizing autophagic mechanism#GO:0061919;positive regulation of cellular component organization#GO:0051130;biological regulation#GO:0065007;positive regulation of biological process#GO:0048518;autophagy#GO:0006914;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;regulation of anatomical structure morphogenesis#GO:0022603;metabolic process#GO:0008152;autophagy of mitochondrion#GO:0000422;positive regulation of developmental process#GO:0051094;regulation of apoptotic process#GO:0042981 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=29302|UniProtKB=Q8TCG1 Q8TCG1 CIP2A PTHR23161:SF2 PROTEIN CIP2A PROTEIN CIP2A enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;protein phosphatase regulator activity#GO:0019888;phosphatase regulator activity#GO:0019208;molecular function regulator activity#GO:0098772;phosphatase inhibitor activity#GO:0019212;protein phosphatase inhibitor activity#GO:0004864;enzyme inhibitor activity#GO:0004857 chromosome organization#GO:0051276;cellular component organization or biogenesis#GO:0071840;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cellular component organization#GO:0016043;response to stress#GO:0006950;organelle organization#GO:0006996 intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;chromosome#GO:0005694;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737 HUMAN|HGNC=27561|UniProtKB=Q7Z6J9 Q7Z6J9 TSEN54 PTHR21027:SF1 TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54 TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54 nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;tRNA splicing, via endonucleolytic cleavage and ligation#GO:0006388;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;gene expression#GO:0010467 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;endonuclease complex#GO:1905348;endoribonuclease complex#GO:1902555;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226 endoribonuclease#PC00094 HUMAN|HGNC=1961|UniProtKB=P11230 P11230 CHRNB1 PTHR18945:SF477 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR SUBUNIT BETA monoatomic ion transmembrane transporter activity#GO:0015075;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion channel activity#GO:0005216;signaling receptor activity#GO:0038023;neurotransmitter receptor activity#GO:0030594;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;postsynaptic neurotransmitter receptor activity#GO:0098960;gated channel activity#GO:0022836;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;monoatomic cation channel activity#GO:0005261;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;molecular transducer activity#GO:0060089;channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276 transport#GO:0006810;muscle contraction#GO:0006936;system process#GO:0003008;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;cellular response to nitrogen compound#GO:1901699;multicellular organismal process#GO:0032501;acetylcholine receptor signaling pathway#GO:0095500;synaptic transmission, cholinergic#GO:0007271;neuromuscular process#GO:0050905;trans-synaptic signaling#GO:0099537;response to nitrogen compound#GO:1901698;cell communication#GO:0007154;monoatomic cation transport#GO:0006812;localization#GO:0051179;cellular response to stimulus#GO:0051716;chemical synaptic transmission#GO:0007268;metal ion transport#GO:0030001;membrane depolarization#GO:0051899;striated muscle contraction#GO:0006941;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;calcium ion transport#GO:0006816;regulation of membrane potential#GO:0042391;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;synaptic signaling#GO:0099536;response to chemical#GO:0042221;nervous system process#GO:0050877;response to oxygen-containing compound#GO:1901700;cellular response to chemical stimulus#GO:0070887;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;transmembrane transport#GO:0055085;muscle system process#GO:0003012;regulation of biological process#GO:0050789;signaling#GO:0023052;skeletal muscle contraction#GO:0003009;response to stimulus#GO:0050896 cell junction#GO:0030054;transporter complex#GO:1990351;synaptic membrane#GO:0097060;signaling receptor complex#GO:0043235;plasma membrane#GO:0005886;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;cell periphery#GO:0071944;membrane#GO:0016020;transmembrane transporter complex#GO:1902495;postsynaptic specialization membrane#GO:0099634;postsynaptic membrane#GO:0045211;organelle#GO:0043226;cellular anatomical structure#GO:0110165;synapse#GO:0045202;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;postsynapse#GO:0098794 ligand-gated ion channel#PC00141 Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086;Nicotinic acetylcholine receptor signaling pathway#P00044>beta#P01095 HUMAN|HGNC=26174|UniProtKB=Q6PK18 Q6PK18 OGFOD3 PTHR14650:SF1 PROLYL HYDROXYLASE-RELATED 2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE DOMAIN-CONTAINING PROTEIN 3 protein modifying enzyme#PC00260 HUMAN|HGNC=6762|UniProtKB=Q9Y6D9 Q9Y6D9 MAD1L1 PTHR23168:SF0 MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1 MITOTIC ARREST DEFICIENT-LIKE PROTEIN 1 MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 negative regulation of chromosome organization#GO:2001251;organelle localization#GO:0051640;intracellular signal transduction#GO:0035556;localization#GO:0051179;cell communication#GO:0007154;organelle fission#GO:0048285;mitotic metaphase chromosome alignment#GO:0007080;mitotic cell cycle checkpoint signaling#GO:0007093;negative regulation of cellular component organization#GO:0051129;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;mitotic cell cycle#GO:0000278;negative regulation of cell cycle process#GO:0010948;regulation of chromosome organization#GO:0033044;regulation of mitotic nuclear division#GO:0007088;regulation of mitotic sister chromatid separation#GO:0010965;regulation of mitotic cell cycle#GO:0007346;mitotic sister chromatid segregation#GO:0000070;negative regulation of nuclear division#GO:0051784;regulation of nuclear division#GO:0051783;negative regulation of mitotic sister chromatid separation#GO:2000816;negative regulation of mitotic cell cycle#GO:0045930;regulation of mitotic cell cycle phase transition#GO:1901990;cellular component organization#GO:0016043;signaling#GO:0023052;regulation of sister chromatid segregation#GO:0033045;chromosome segregation#GO:0007059;regulation of chromosome segregation#GO:0051983;metaphase chromosome alignment#GO:0051310;negative regulation of cell cycle#GO:0045786;mitotic spindle assembly checkpoint signaling#GO:0007094;attachment of spindle microtubules to kinetochore#GO:0008608;regulation of cell cycle process#GO:0010564;chromosome localization#GO:0050000;cell cycle checkpoint signaling#GO:0000075;attachment of mitotic spindle microtubules to kinetochore#GO:0051315;regulation of mitotic sister chromatid segregation#GO:0033047;cellular response to stimulus#GO:0051716;negative regulation of mitotic metaphase/anaphase transition#GO:0045841;cell cycle#GO:0007049;regulation of cell cycle phase transition#GO:1901987;negative regulation of organelle organization#GO:0010639;regulation of cellular process#GO:0050794;negative regulation of cellular process#GO:0048523;negative regulation of chromosome separation#GO:1905819;mitotic cell cycle process#GO:1903047;chromosome organization#GO:0051276;biological regulation#GO:0065007;regulation of mitotic metaphase/anaphase transition#GO:0030071;nuclear division#GO:0000280;negative regulation of mitotic nuclear division#GO:0045839;regulation of biological process#GO:0050789;cell cycle process#GO:0022402;mitotic nuclear division#GO:0140014;regulation of organelle organization#GO:0033043;negative regulation of biological process#GO:0048519;nuclear chromosome segregation#GO:0098813;sister chromatid segregation#GO:0000819;negative regulation of cell cycle phase transition#GO:1901988;regulation of cell cycle#GO:0051726;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;negative regulation of mitotic sister chromatid segregation#GO:0033048;negative regulation of metaphase/anaphase transition of cell cycle#GO:1902100;negative regulation of chromosome segregation#GO:0051985;cellular component organization or biogenesis#GO:0071840;signal transduction#GO:0007165;cellular process#GO:0009987;organelle organization#GO:0006996;negative regulation of sister chromatid segregation#GO:0033046;negative regulation of mitotic cell cycle phase transition#GO:1901991;regulation of chromosome separation#GO:1905818 mitotic spindle#GO:0072686;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;kinetochore#GO:0000776;organelle envelope#GO:0031967;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nuclear envelope#GO:0005635;intracellular membraneless organelle#GO:0043232;supramolecular complex#GO:0099080;endomembrane system#GO:0012505;nucleus#GO:0005634;microtubule cytoskeleton#GO:0015630;condensed chromosome, centromeric region#GO:0000779;membraneless organelle#GO:0043228;spindle#GO:0005819;condensed chromosome#GO:0000793;cytoskeleton#GO:0005856;chromosome, centromeric region#GO:0000775 HUMAN|HGNC=17585|UniProtKB=Q6ZWJ8 Q6ZWJ8 KCP PTHR46698:SF2 CROSSVEINLESS 2 KIELIN_CHORDIN-LIKE PROTEIN regulation of BMP signaling pathway#GO:0030510;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of cellular response to growth factor stimulus#GO:0090287;regulation of signal transduction#GO:0009966;regulation of response to stimulus#GO:0048583;positive regulation of BMP signaling pathway#GO:0030513;positive regulation of signal transduction#GO:0009967;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of cell communication#GO:0010646;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=2175|UniProtKB=O94779 O94779 CNTN5 PTHR10075:SF134 BASIGIN RELATED CONTACTIN-5 cell adhesion molecule#PC00069 HUMAN|HGNC=18890|UniProtKB=Q9BYR6 Q9BYR6 KRTAP3-3 PTHR23260:SF1 KERATIN ASSOCIATED PROTEIN 3-3-RELATED KERATIN-ASSOCIATED PROTEIN 3-3 structural protein#PC00211 HUMAN|HGNC=15001|UniProtKB=Q8NGZ0 Q8NGZ0 OR2AJ1 PTHR26453:SF214 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2AJ1 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;detection of chemical stimulus#GO:0009593;response to chemical#GO:0042221;response to stimulus#GO:0050896;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;sensory perception#GO:0007600;nervous system process#GO:0050877;system process#GO:0003008 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=16487|UniProtKB=Q9NPF8 Q9NPF8 ADAP2 PTHR46021:SF6 ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 1-LIKE PROTEIN ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 2 molecular function activator activity#GO:0140677;lipid binding#GO:0008289;enzyme regulator activity#GO:0030234;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;anion binding#GO:0043168;molecular function regulator activity#GO:0098772;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;phosphatidylinositol phosphate binding#GO:1901981;enzyme activator activity#GO:0008047;phospholipid binding#GO:0005543 multicellular organismal process#GO:0032501;heart development#GO:0007507;circulatory system development#GO:0072359;system development#GO:0048731;animal organ development#GO:0048513;anatomical structure development#GO:0048856;multicellular organism development#GO:0007275;developmental process#GO:0032502;animal gross anatomical part developmental process#GO:0160108 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=15078|UniProtKB=Q8NGB8 Q8NGB8 OR4F15 PTHR48002:SF94 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 4F15 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=25934|UniProtKB=Q8N594 Q8N594 MPND PTHR10410:SF41 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED MPN DOMAIN-CONTAINING PROTEIN ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;deubiquitinase activity#GO:0101005;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 DNA damage response#GO:0006974;cellular response to stress#GO:0033554;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;primary metabolic process#GO:0044238;nucleobase-containing compound metabolic process#GO:0006139;response to stimulus#GO:0050896 translation factor#PC00223;translation initiation factor#PC00224 HUMAN|HGNC=613|UniProtKB=P02649 P02649 APOE PTHR18976:SF2 APOLIPOPROTEIN APOLIPOPROTEIN E phospholipid binding#GO:0005543;enzyme activator activity#GO:0008047;sterol transfer activity#GO:0120015;transporter activity#GO:0005215;cholesterol transfer activity#GO:0120020;molecular function regulator activity#GO:0098772;binding#GO:0005488;molecular carrier activity#GO:0140104;lipid carrier activity#GO:0005319;enzyme regulator activity#GO:0030234;lipid binding#GO:0008289;molecular function activator activity#GO:0140677;lipid transfer activity#GO:0120013 small molecule metabolic process#GO:0044281;organophosphate ester transport#GO:0015748;secondary alcohol metabolic process#GO:1902652;homeostatic process#GO:0042592;primary metabolic process#GO:0044238;lipid homeostasis#GO:0055088;localization#GO:0051179;organic hydroxy compound transport#GO:0015850;lipid localization#GO:0010876;lipid transport#GO:0006869;steroid metabolic process#GO:0008202;phospholipid transport#GO:0015914;macromolecule localization#GO:0033036;cholesterol transport#GO:0030301;cholesterol efflux#GO:0033344;cellular process#GO:0009987;sterol metabolic process#GO:0016125;sterol transport#GO:0015918;establishment of localization#GO:0051234;metabolic process#GO:0008152;alcohol metabolic process#GO:0006066;cholesterol metabolic process#GO:0008203;chemical homeostasis#GO:0048878;lipid metabolic process#GO:0006629;transport#GO:0006810 organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;vesicle#GO:0031982;very-low-density lipoprotein particle#GO:0034361;membrane-bounded organelle#GO:0043227;plasma lipoprotein particle#GO:0034358;high-density lipoprotein particle#GO:0034364;protein-lipid complex#GO:0032994;extracellular protein-containing complex#GO:0140392;extracellular region#GO:0005576;lipoprotein particle#GO:1990777 transfer/carrier protein#PC00219;apolipoprotein#PC00052 HUMAN|HGNC=21082|UniProtKB=Q9UGP8 Q9UGP8 SEC63 PTHR24075:SF0 SEC63 DOMAIN-CONTAINING TRANSLOCATION PROTEIN SEC63 HOMOLOG nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 establishment of protein localization to endoplasmic reticulum#GO:0072599;post-translational protein targeting to endoplasmic reticulum membrane#GO:0006620;protein targeting#GO:0006605;establishment of protein localization#GO:0045184;cellular process#GO:0009987;establishment of protein localization to membrane#GO:0090150;protein targeting to ER#GO:0045047;establishment of protein localization to organelle#GO:0072594;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization within membrane#GO:0051668;SRP-dependent cotranslational protein targeting to membrane#GO:0006614;protein targeting to membrane#GO:0006612 rough endoplasmic reticulum#GO:0005791;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;rough endoplasmic reticulum membrane#GO:0030867;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;endoplasmic reticulum protein-containing complex#GO:0140534;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HUMAN|HGNC=30213|UniProtKB=Q9NQ11 Q9NQ11 ATP13A2 PTHR45630:SF2 CATION-TRANSPORTING ATPASE-RELATED POLYAMINE-TRANSPORTING ATPASE 13A2 polyamine transmembrane transporter activity#GO:0015203;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 regulation of organelle organization#GO:0033043;regulation of cellular component size#GO:0032535;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;intracellular monoatomic ion homeostasis#GO:0006873;regulation of cellular component organization#GO:0051128;inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;regulation of biological quality#GO:0065008;process utilizing autophagic mechanism#GO:0061919;transmembrane transport#GO:0055085;cellular process#GO:0009987;autophagosome organization#GO:1905037;autophagy#GO:0006914;monoatomic ion homeostasis#GO:0050801;organelle organization#GO:0006996;organelle membrane fusion#GO:0090174;vesicle-mediated transport#GO:0016192;organelle fusion#GO:0048284;chemical homeostasis#GO:0048878;metabolic process#GO:0008152;regulation of anatomical structure size#GO:0090066;vesicle organization#GO:0016050;intracellular calcium ion homeostasis#GO:0006874;cellular component organization or biogenesis#GO:0071840;regulation of mitochondrion organization#GO:0010821;vesicle fusion#GO:0006906;homeostatic process#GO:0042592;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;vacuole organization#GO:0007033;localization#GO:0051179;nitrogen compound transport#GO:0071705;membrane fusion#GO:0061025;macroautophagy#GO:0016236;membrane organization#GO:0061024;biological regulation#GO:0065007;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;establishment of localization#GO:0051234 bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;late endosome membrane#GO:0031902;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;late endosome#GO:0005770;endomembrane system#GO:0012505;membrane#GO:0016020;vesicle membrane#GO:0012506;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endosome membrane#GO:0010008;endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular vesicle#GO:0097708 primary active transporter#PC00068 HUMAN|HGNC=23156|UniProtKB=P26368 P26368 U2AF2 PTHR23139:SF9 RNA-BINDING PROTEIN SPLICING FACTOR U2AF 65 KDA SUBUNIT pre-mRNA binding#GO:0036002;nucleic acid binding#GO:0003676;binding#GO:0005488;single-stranded RNA binding#GO:0003727;RNA binding#GO:0003723 primary metabolic process#GO:0044238;cellular component organization#GO:0016043;nucleic acid metabolic process#GO:0090304;protein-containing complex assembly#GO:0065003;mRNA splicing, via spliceosome#GO:0000398;ribonucleoprotein complex biogenesis#GO:0022613;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;RNA splicing, via transesterification reactions#GO:0000375;spliceosomal complex assembly#GO:0000245;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;protein-RNA complex assembly#GO:0022618;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;cellular component biogenesis#GO:0044085;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;cellular component assembly#GO:0022607;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;protein-RNA complex organization#GO:0071826;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-containing complex organization#GO:0043933 nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;U2-type prespliceosome#GO:0071004;intracellular membrane-bounded organelle#GO:0043231;U2-type spliceosomal complex#GO:0005684;spliceosomal complex#GO:0005681;organelle lumen#GO:0043233;nuclear speck#GO:0016607;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;nuclear body#GO:0016604;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228 HUMAN|HGNC=13429|UniProtKB=Q9NVW2 Q9NVW2 RLIM PTHR45931:SF4 SI:CH211-59O9.10 E3 UBIQUITIN-PROTEIN LIGASE RLIM ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824 protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;protein modification process#GO:0036211;primary metabolic process#GO:0044238;heterochromatin formation#GO:0031507;modification-dependent protein catabolic process#GO:0019941;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;post-translational protein modification#GO:0043687;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;chromatin organization#GO:0006325;epigenetic regulation of gene expression#GO:0040029;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;protein modification by small protein conjugation or removal#GO:0070647;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;protein modification by small protein conjugation#GO:0032446;regulation of biological process#GO:0050789;negative regulation of gene expression, epigenetic#GO:0045814;cellular component organization or biogenesis#GO:0071840;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;cellular component assembly#GO:0022607;heterochromatin organization#GO:0070828;protein ubiquitination#GO:0016567;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=54075|UniProtKB=A0A2R8YCJ5 A0A2R8YCJ5 SMIM41 PTHR28649:SF1 PROTEIN REPRIMO-RELATED SMALL INTEGRAL MEMBRANE PROTEIN 41 HUMAN|HGNC=3953|UniProtKB=P62166 P62166 NCS1 PTHR23055:SF198 CALCIUM BINDING PROTEINS NEURONAL CALCIUM SENSOR 1 enzyme activator activity#GO:0008047;cyclase regulator activity#GO:0010851;molecular function regulator activity#GO:0098772;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;calcium ion binding#GO:0005509;enzyme regulator activity#GO:0030234;metal ion binding#GO:0046872;molecular function activator activity#GO:0140677;cation binding#GO:0043169 calmodulin-related#PC00061 HUMAN|HGNC=6351|UniProtKB=O95600 O95600 KLF8 PTHR23235:SF46 KRUEPPEL-LIKE TRANSCRIPTION FACTOR KRUEPPEL-LIKE FACTOR 8 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=18345|UniProtKB=Q96IP4 Q96IP4 TENT5A PTHR12974:SF25 PRION-LIKE- Q/N-RICH -DOMAIN-BEARING PROTEIN PROTEIN 44 TERMINAL NUCLEOTIDYLTRANSFERASE 5A catalytic activity#GO:0003824;transferase activity#GO:0016740;nucleotidyltransferase activity#GO:0016779;transferase activity, transferring phosphorus-containing groups#GO:0016772;adenylyltransferase activity#GO:0070566 regulation of biological process#GO:0050789;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;regulation of mRNA stability#GO:0043488;negative regulation of metabolic process#GO:0009892;regulation of biological quality#GO:0065008;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;RNA stabilization#GO:0043489;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of biological process#GO:0048518;mRNA stabilization#GO:0048255;positive regulation of macromolecule metabolic process#GO:0010604;negative regulation of RNA metabolic process#GO:0051253;regulation of mRNA metabolic process#GO:1903311;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA stability#GO:0043487;regulation of RNA metabolic process#GO:0051252;negative regulation of catabolic process#GO:0009895;positive regulation of biosynthetic process#GO:0009891;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of RNA catabolic process#GO:1902369;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;positive regulation of gene expression#GO:0010628;regulation of biosynthetic process#GO:0009889 HUMAN|HGNC=12781|UniProtKB=Q93097 Q93097 WNT2B PTHR12027:SF93 WNT RELATED PROTEIN WNT-2B molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;G protein-coupled receptor binding#GO:0001664;frizzled binding#GO:0005109;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;molecular function activator activity#GO:0140677;protein binding#GO:0005515;cytokine activity#GO:0005125;binding#GO:0005488;signaling receptor binding#GO:0005102 cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cell differentiation#GO:0030154;Wnt signaling pathway#GO:0016055;signaling#GO:0023052;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;anatomical structure development#GO:0048856;cell communication#GO:0007154;canonical Wnt signaling pathway#GO:0060070;system development#GO:0048731;cell fate commitment#GO:0045165;cellular process#GO:0009987;signal transduction#GO:0007165;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;biological regulation#GO:0065007;cell surface receptor signaling pathway#GO:0007166;developmental process#GO:0032502;neuron differentiation#GO:0030182;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;neurogenesis#GO:0022008 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 Alzheimer disease-presenilin pathway#P00004>Wnt#P00142;Wnt signaling pathway#P00057>Wnt#P01444;Angiogenesis#P00005>Wnt#P00206;Cadherin signaling pathway#P00012>Wnt#P00474 HUMAN|HGNC=23837|UniProtKB=Q32M45 Q32M45 ANO4 PTHR12308:SF28 ANOCTAMIN ANOCTAMIN-4 intramembrane lipid carrier activity#GO:0140303;phospholipid scramblase activity#GO:0017128;transporter activity#GO:0005215;lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104 membrane organization#GO:0061024;biological regulation#GO:0065007;phospholipid translocation#GO:0045332;phospholipid transport#GO:0015914;lipid transport#GO:0006869;cellular process#GO:0009987;macromolecule localization#GO:0033036;regulation of membrane lipid distribution#GO:0097035;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;transport#GO:0006810;lipid translocation#GO:0034204;organophosphate ester transport#GO:0015748;cellular component organization#GO:0016043;regulation of biological quality#GO:0065008;localization#GO:0051179;lipid localization#GO:0010876 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=15311|UniProtKB=Q8NGG1 Q8NGG1 OR8J2 PTHR48018:SF212 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 8J2 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 G protein-coupled receptor signaling pathway#GO:0007186;nervous system process#GO:0050877;sensory perception#GO:0007600;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;sensory perception of smell#GO:0007608;response to stimulus#GO:0050896;signaling#GO:0023052;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;cellular process#GO:0009987;signal transduction#GO:0007165;multicellular organismal process#GO:0032501;biological regulation#GO:0065007 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=1764|UniProtKB=P33151 P33151 CDH5 PTHR24027:SF89 CADHERIN-23 CADHERIN-5 enzyme binding#GO:0019899;cell adhesion molecule binding#GO:0050839;binding#GO:0005488;phosphatase binding#GO:0019902;protein phosphatase binding#GO:0019903;beta-catenin binding#GO:0008013;protein binding#GO:0005515 anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;adherens junction organization#GO:0034332;cell junction assembly#GO:0034329;cell morphogenesis#GO:0000902;cell junction organization#GO:0034330;cell motility#GO:0048870;cell adhesion#GO:0007155;anatomical structure development#GO:0048856;cellular process#GO:0009987;cell-cell adhesion#GO:0098609;cellular component biogenesis#GO:0044085;cell migration#GO:0016477;cellular component assembly#GO:0022607;cell-cell junction assembly#GO:0007043;developmental process#GO:0032502;cell-cell junction organization#GO:0045216;cellular component organization or biogenesis#GO:0071840 apical junction complex#GO:0043296;adherens junction#GO:0005912;extrinsic component of plasma membrane#GO:0019897;tight junction#GO:0070160;extrinsic component of membrane#GO:0019898;cell junction#GO:0030054;cell periphery#GO:0071944;cell-cell junction#GO:0005911;membrane#GO:0016020;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;bicellular tight junction#GO:0005923;anchoring junction#GO:0070161;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;cellular anatomical structure#GO:0110165 cell adhesion molecule#PC00069;cadherin#PC00057 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HUMAN|HGNC=6228|UniProtKB=Q14722 Q14722 KCNAB1 PTHR43150:SF7 HYPERKINETIC, ISOFORM M VOLTAGE-GATED POTASSIUM CHANNEL SUBUNIT BETA-1 transporter regulator activity#GO:0141108;potassium channel regulator activity#GO:0015459;transmembrane transporter binding#GO:0044325;binding#GO:0005488;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;channel regulator activity#GO:0016247;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;protein binding#GO:0005515;catalytic activity#GO:0003824;ion channel regulator activity#GO:0099106;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;molecular function regulator activity#GO:0098772;alcohol dehydrogenase (NADP+) activity#GO:0008106;oxidoreductase activity#GO:0016491 regulation of cellular process#GO:0050794;regulation of metal ion transport#GO:0010959;regulation of monoatomic ion transport#GO:0043269;biological regulation#GO:0065007;regulation of transmembrane transport#GO:0034762;regulation of monoatomic ion transmembrane transport#GO:0034765;regulation of biological process#GO:0050789;regulation of transport#GO:0051049;regulation of localization#GO:0032879;regulation of monoatomic cation transmembrane transport#GO:1904062 axon#GO:0030424;transmembrane transporter complex#GO:1902495;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cation channel complex#GO:0034703;voltage-gated potassium channel complex#GO:0008076;transporter complex#GO:1990351;membrane#GO:0016020;neuron projection#GO:0043005;main axon#GO:0044304;cell periphery#GO:0071944;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane#GO:0005886 HUMAN|HGNC=15837|UniProtKB=Q96GQ7 Q96GQ7 DDX27 PTHR24031:SF706 RNA HELICASE ATP-DEPENDENT RNA HELICASE DDX27-RELATED rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774 nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular organelle#GO:0043229;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 RNA metabolism protein#PC00031;RNA helicase#PC00032 HUMAN|HGNC=3798|UniProtKB=P15408 P15408 FOSL2 PTHR23351:SF25 FOS TRANSCRIPTION FACTOR-RELATED FOS-RELATED ANTIGEN 2 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 basic leucine zipper transcription factor#PC00056 HUMAN|HGNC=17410|UniProtKB=Q9GZV7 Q9GZV7 HAPLN2 PTHR22804:SF8 AGGRECAN/VERSICAN PROTEOGLYCAN HYALURONAN AND PROTEOGLYCAN LINK PROTEIN 2 nervous system development#GO:0007399;multicellular organismal process#GO:0032501;central nervous system development#GO:0007417;system development#GO:0048731;anatomical structure development#GO:0048856;skeletal system development#GO:0001501;multicellular organism development#GO:0007275;developmental process#GO:0032502;animal gross anatomical part developmental process#GO:0160108 cell junction#GO:0030054;extracellular region#GO:0005576;plasma membrane#GO:0005886;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;external encapsulating structure#GO:0030312;membrane#GO:0016020;extracellular matrix#GO:0031012 extracellular matrix protein#PC00102;extracellular matrix glycoprotein#PC00100 HUMAN|Ensembl=ENSG00000288429.1|UniProtKB=A0AAG2TV02 A0AAG2TV02 PTHR23266:SF346 IMMUNOGLOBULIN HEAVY CHAIN IG-LIKE DOMAIN-CONTAINING PROTEIN antigen binding#GO:0003823;binding#GO:0005488 immune system process#GO:0002376;immune effector process#GO:0002252;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;immune response#GO:0006955;response to stimulus#GO:0050896;adaptive immune response#GO:0002250 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=4795|UniProtKB=O95479 O95479 H6PD PTHR23429:SF7 GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD GDH_6PGL ENDOPLASMIC BIFUNCTIONAL PROTEIN oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824;glucose-6-phosphate dehydrogenase activity#GO:0004345;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491 nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;nicotinamide nucleotide metabolic process#GO:0046496;carbohydrate derivative metabolic process#GO:1901135;NADP+ metabolic process#GO:0006739;organophosphate metabolic process#GO:0019637;nucleobase-containing small molecule metabolic process#GO:0055086;glucose metabolic process#GO:0006006;pentose-phosphate shunt, oxidative branch#GO:0009051;generation of precursor metabolites and energy#GO:0006091;monosaccharide metabolic process#GO:0005996;metabolic process#GO:0008152;nucleoside phosphate metabolic process#GO:0006753;carbohydrate metabolic process#GO:0005975;small molecule metabolic process#GO:0044281;glucose 6-phosphate metabolic process#GO:0051156;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;primary metabolic process#GO:0044238;hexose metabolic process#GO:0019318;phosphorus metabolic process#GO:0006793;nucleotide metabolic process#GO:0009117;NADPH regeneration#GO:0006740;pyridine-containing compound metabolic process#GO:0072524;pentose-phosphate shunt#GO:0006098 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 dehydrogenase#PC00092 HUMAN|HGNC=866|UniProtKB=Q9HBG4 Q9HBG4 ATP6V0A4 PTHR11629:SF26 VACUOLAR PROTON ATPASES V-TYPE PROTON ATPASE 116 KDA SUBUNIT A 4 monoatomic cation transmembrane transporter activity#GO:0008324;protein binding#GO:0005515;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;enzyme binding#GO:0019899;binding#GO:0005488;active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;proton transmembrane transporter activity#GO:0015078 regulation of pH#GO:0006885;regulation of intracellular pH#GO:0051453;localization#GO:0051179;monoatomic cation transport#GO:0006812;catabolic process#GO:0009056;protein-containing complex disassembly#GO:0032984;homeostatic process#GO:0042592;autophagosome maturation#GO:0097352;monoatomic cation homeostasis#GO:0055080;transport#GO:0006810;intracellular monoatomic cation homeostasis#GO:0030003;establishment of localization#GO:0051234;vacuolar acidification#GO:0007035;proton transmembrane transport#GO:1902600;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;macroautophagy#GO:0016236;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;transmembrane transport#GO:0055085;cellular component disassembly#GO:0022411;process utilizing autophagic mechanism#GO:0061919;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;cellular component organization#GO:0016043;intracellular monoatomic ion homeostasis#GO:0006873;metabolic process#GO:0008152;chemical homeostasis#GO:0048878;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;autophagy#GO:0006914;monoatomic cation transmembrane transport#GO:0098655 plasma membrane region#GO:0098590;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;brush border#GO:0005903;vacuolar membrane#GO:0005774;proton-transporting V-type ATPase complex#GO:0033176;organelle membrane#GO:0031090;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;apical plasma membrane#GO:0016324;membrane protein complex#GO:0098796;cation-transporting ATPase complex#GO:0090533;transmembrane transporter complex#GO:1902495;cluster of actin-based cell projections#GO:0098862;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;vacuolar proton-transporting V-type ATPase complex#GO:0016471;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;brush border membrane#GO:0031526;vacuole#GO:0005773;cytoplasm#GO:0005737;transporter complex#GO:1990351;bounding membrane of organelle#GO:0098588;apical part of cell#GO:0045177;proton-transporting two-sector ATPase complex#GO:0016469;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;cell projection membrane#GO:0031253;ATPase dependent transmembrane transport complex#GO:0098533;intracellular organelle#GO:0043229;ATPase complex#GO:1904949 ATP synthase#PC00002 HUMAN|HGNC=1610|UniProtKB=P51686 P51686 CCR9 PTHR10489:SF664 CELL ADHESION MOLECULE C-C CHEMOKINE RECEPTOR TYPE 9 cytokine receptor activity#GO:0004896;signaling receptor activity#GO:0038023;cytokine binding#GO:0019955;immune receptor activity#GO:0140375;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488;protein binding#GO:0005515;molecular transducer activity#GO:0060089 response to external stimulus#GO:0009605;calcium-mediated signaling#GO:0019722;immune response#GO:0006955;signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124;response to chemical#GO:0042221;taxis#GO:0042330;cell migration#GO:0016477;chemotaxis#GO:0006935;positive regulation of cytosolic calcium ion concentration#GO:0007204;immune system process#GO:0002376;cellular response to chemical stimulus#GO:0070887;cell chemotaxis#GO:0060326;regulation of biological quality#GO:0065008;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;signaling#GO:0023052;locomotion#GO:0040011;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell motility#GO:0048870 membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;plasma membrane#GO:0005886 cell adhesion molecule#PC00069 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CHKR#P00854 HUMAN|HGNC=11973|UniProtKB=Q9HBL0 Q9HBL0 TNS1 PTHR45734:SF3 TENSIN TENSIN-1 cellular process#GO:0009987;cell migration#GO:0016477;cell motility#GO:0048870 anchoring junction#GO:0070161;cell-substrate junction#GO:0030055;focal adhesion#GO:0005925;cellular anatomical structure#GO:0110165;cell junction#GO:0030054 actin or actin-binding cytoskeletal protein#PC00041;cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HUMAN|HGNC=33454|UniProtKB=Q6NV74 Q6NV74 CRACDL PTHR47743:SF1 KIAA1210 / KIAA1211 FAMILY MEMBER CRACD-LIKE PROTEIN HUMAN|HGNC=15677|UniProtKB=Q9H2K2 Q9H2K2 TNKS2 PTHR24180:SF11 CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED POLY [ADP-RIBOSE] POLYMERASE TANKYRASE-2 glycosyltransferase activity#GO:0016757;transferase activity#GO:0016740;catalytic activity#GO:0003824;NAD+ poly-ADP-ribosyltransferase activity#GO:0003950;pentosyltransferase activity#GO:0016763 regulation of cell communication#GO:0010646;protein localization to organelle#GO:0033365;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of macromolecule metabolic process#GO:0060255;positive regulation of DNA metabolic process#GO:0051054;positive regulation of signal transduction#GO:0009967;localization#GO:0051179;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of response to stimulus#GO:0048584;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;macromolecule localization#GO:0033036;regulation of telomere maintenance#GO:0032204;intracellular protein localization#GO:0008104;positive regulation of canonical Wnt signaling pathway#GO:0090263;regulation of response to stimulus#GO:0048583;regulation of chromosome organization#GO:0033044;regulation of Wnt signaling pathway#GO:0030111;regulation of cellular component organization#GO:0051128;regulation of DNA metabolic process#GO:0051052;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;positive regulation of organelle organization#GO:0010638;positive regulation of signaling#GO:0023056;positive regulation of metabolic process#GO:0009893;regulation of signaling#GO:0023051;positive regulation of cellular component organization#GO:0051130;positive regulation of Wnt signaling pathway#GO:0030177;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;regulation of canonical Wnt signaling pathway#GO:0060828 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 kinase inhibitor#PC00139;kinase modulator#PC00140 HUMAN|HGNC=4933|UniProtKB=P10321 P10321 HLA-C PTHR16675:SF294 MHC CLASS I-RELATED HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, C ALPHA CHAIN protein binding#GO:0005515;peptide binding#GO:0042277;antigen binding#GO:0003823;signaling receptor binding#GO:0005102;binding#GO:0005488 regulation of immune response#GO:0050776;regulation of cell killing#GO:0031341;immune system process#GO:0002376;regulation of lymphocyte mediated immunity#GO:0002706;regulation of leukocyte mediated cytotoxicity#GO:0001910;positive regulation of lymphocyte mediated immunity#GO:0002708;regulation of immune effector process#GO:0002697;antigen processing and presentation#GO:0019882;regulation of biological process#GO:0050789;regulation of leukocyte mediated immunity#GO:0002703;positive regulation of adaptive immune response#GO:0002821;response to stimulus#GO:0050896;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;positive regulation of leukocyte mediated immunity#GO:0002705;immune response#GO:0006955;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of immune system process#GO:0002684;biological regulation#GO:0065007;positive regulation of immune effector process#GO:0002699;positive regulation of response to stimulus#GO:0048584 cellular anatomical structure#GO:0110165;cell surface#GO:0009986;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;side of membrane#GO:0098552;external side of plasma membrane#GO:0009897;extracellular region#GO:0005576 major histocompatibility complex protein#PC00149;defense/immunity protein#PC00090 HUMAN|HGNC=6628|UniProtKB=Q15334 Q15334 LLGL1 PTHR10241:SF21 LETHAL 2 GIANT LARVAE PROTEIN LETHAL(2) GIANT LARVAE PROTEIN HOMOLOG 1 binding#GO:0005488;enzyme regulator activity#GO:0030234;protein binding#GO:0005515;molecular function activator activity#GO:0140677;syntaxin binding#GO:0019905;myosin binding#GO:0017022;SNARE binding#GO:0000149;enzyme activator activity#GO:0008047;cytoskeletal protein binding#GO:0008092;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;molecular function regulator activity#GO:0098772 establishment of localization#GO:0051234;vesicle-mediated transport to the plasma membrane#GO:0098876;transport#GO:0006810;regulation of response to stimulus#GO:0048583;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;establishment of spindle localization#GO:0051293;secretion#GO:0046903;microtubule cytoskeleton organization#GO:0000226;localization#GO:0051179;cortical actin cytoskeleton organization#GO:0030866;organelle localization#GO:0051640;cortical cytoskeleton organization#GO:0030865;actin filament-based process#GO:0030029;regulation of Notch signaling pathway#GO:0008593;localization within membrane#GO:0051668;regulation of cellular process#GO:0050794;actin cytoskeleton organization#GO:0030036;Golgi to plasma membrane transport#GO:0006893;regulation of cell communication#GO:0010646;cell cycle#GO:0007049;establishment of cell polarity#GO:0030010;cellular component organization or biogenesis#GO:0071840;establishment of spindle orientation#GO:0051294;microtubule-based process#GO:0007017;exocytosis#GO:0006887;Golgi vesicle transport#GO:0048193;regulation of establishment or maintenance of cell polarity#GO:0032878;vesicle-mediated transport#GO:0016192;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;cellular localization#GO:0051641;spindle localization#GO:0051653;secretion by cell#GO:0032940;post-Golgi vesicle-mediated transport#GO:0006892;establishment or maintenance of cell polarity#GO:0007163;regulation of signaling#GO:0023051;establishment of organelle localization#GO:0051656;export from cell#GO:0140352;cellular component organization#GO:0016043;cell cycle process#GO:0022402;regulation of biological process#GO:0050789 intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;cytoplasm#GO:0005737;cortical actin cytoskeleton#GO:0030864;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell cortex#GO:0005938;cell periphery#GO:0071944;actin cytoskeleton#GO:0015629;membrane#GO:0016020;cortical cytoskeleton#GO:0030863;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=29408|UniProtKB=B1AJZ9 B1AJZ9 FHAD1 PTHR18853:SF7 FORKHEAD-ASSOCIATED DOMAIN-CONTAINING PROTEIN 1-RELATED FORKHEAD-ASSOCIATED DOMAIN-CONTAINING PROTEIN 1 winged helix/forkhead transcription factor#PC00246;DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=3496|UniProtKB=O60487 O60487 MPZL2 PTHR13869:SF21 MYELIN P0 RELATED MYELIN PROTEIN ZERO-LIKE PROTEIN 2 cell adhesion#GO:0007155;cellular process#GO:0009987;cell-cell adhesion#GO:0098609 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 myelin protein#PC00161 HUMAN|HGNC=27323|UniProtKB=P0C7A2 P0C7A2 FAM153B PTHR40712:SF2 FAMILY WITH SEQUENCE SIMILARITY 153 MEMBER C-RELATED FAMILY WITH SEQUENCE SIMILARITY 153 MEMBER C, PSEUDOGENE-RELATED HUMAN|HGNC=24717|UniProtKB=Q96EY7 Q96EY7 PTCD3 PTHR16276:SF1 PENTATRICOPEPTIDE REPEAT DOMAIN-CONTAINING PROTEIN 3 SMALL RIBOSOMAL SUBUNIT PROTEIN MS39 nucleic acid binding#GO:0003676;rRNA binding#GO:0019843;binding#GO:0005488;RNA binding#GO:0003723;ribonucleoprotein complex binding#GO:0043021;ribosome binding#GO:0043022;protein-containing complex binding#GO:0044877 primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein biosynthetic process#GO:0160307;mitochondrial translation#GO:0032543;gene expression#GO:0010467;biosynthetic process#GO:0009058;metabolic process#GO:0008152;translation#GO:0006412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;mitochondrial gene expression#GO:0140053 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=13997|UniProtKB=Q9H4Q4 Q9H4Q4 PRDM12 PTHR16515:SF20 PR DOMAIN ZINC FINGER PROTEIN PR DOMAIN ZINC FINGER PROTEIN 12 protein binding#GO:0005515;enzyme binding#GO:0019899;binding#GO:0005488 developmental process#GO:0032502;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;multicellular organism development#GO:0007275;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;nervous system development#GO:0007399;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;anatomical structure development#GO:0048856;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264;zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=9501|UniProtKB=Q15438 Q15438 CYTH1 PTHR10663:SF340 GUANYL-NUCLEOTIDE EXCHANGE FACTOR CYTOHESIN-1 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=4647|UniProtKB=P52657 P52657 GTF2A2 PTHR10966:SF5 TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2 TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2 binding#GO:0005488;transcription factor binding#GO:0008134;protein binding#GO:0005515 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;transcription initiation at RNA polymerase II promoter#GO:0006367;cellular component biogenesis#GO:0044085;biosynthetic process#GO:0009058;protein-DNA complex assembly#GO:0065004;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;cellular component assembly#GO:0022607;transcription by RNA polymerase II#GO:0006366;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;protein-containing complex organization#GO:0043933;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;protein-DNA complex organization#GO:0071824;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA polymerase II preinitiation complex assembly#GO:0051123;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;DNA-templated transcription initiation#GO:0006352;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070 nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;RNA polymerase II, holoenzyme#GO:0016591;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;membrane-enclosed lumen#GO:0031974;RNA polymerase II transcription regulator complex#GO:0090575;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;transcription regulator complex#GO:0005667;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234 general transcription factor#PC00259 Transcription regulation by bZIP transcription factor#P00055>TFIIA complex#P01390;General transcription regulation#P00023>TFIIA complex#P00662 HUMAN|HGNC=12233|UniProtKB=A0A0A6YYG3 A0A0A6YYG3 TRBV6-8 PTHR23268:SF86 T-CELL RECEPTOR BETA CHAIN T CELL RECEPTOR BETA VARIABLE 6-8-RELATED cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=9530|UniProtKB=P25786 P25786 PSMA1 PTHR11599:SF244 PROTEASOME SUBUNIT ALPHA/BETA PROTEASOME SUBUNIT ALPHA TYPE-1 cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;endopeptidase complex#GO:1905369;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;peptidase complex#GO:1905368;intracellular membrane-bounded organelle#GO:0043231;proteasome complex#GO:0000502;nucleus#GO:0005634 protein modifying enzyme#PC00260;protease#PC00190 Parkinson disease#P00049>20S proteasome#P01227 HUMAN|HGNC=11164|UniProtKB=P63162 P63162 SNRPN PTHR10701:SF24 SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN N binding#GO:0005488;ribonucleoprotein complex binding#GO:0043021;protein-containing complex binding#GO:0044877 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070 nucleus#GO:0005634;small nuclear ribonucleoprotein complex#GO:0030532;cytoplasm#GO:0005737;U4/U6 x U5 tri-snRNP complex#GO:0046540;U1 snRNP#GO:0005685;protein-containing complex#GO:0032991;U2 snRNP#GO:0005686;nuclear protein-containing complex#GO:0140513;U5 snRNP#GO:0005682;Sm-like protein family complex#GO:0120114;catalytic step 2 spliceosome#GO:0071013;spliceosomal complex#GO:0005681;U2-type prespliceosome#GO:0071004;U4 snRNP#GO:0005687;U2-type spliceosomal complex#GO:0005684;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;spliceosomal tri-snRNP complex#GO:0097526;ribonucleoprotein complex#GO:1990904;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;spliceosomal snRNP complex#GO:0097525 RNA splicing factor#PC00148 Gonadotropin-releasing hormone receptor pathway#P06664>SNURF#P06808 HUMAN|HGNC=7804|UniProtKB=P23511 P23511 NFYA PTHR12632:SF122 TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT ALPHA DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 Gonadotropin-releasing hormone receptor pathway#P06664>NF-Y#P06742 HUMAN|HGNC=24955|UniProtKB=Q9Y328 Q9Y328 NSG2 PTHR28546:SF2 NEURONAL VESICLE TRAFFICKING-ASSOCIATED PROTEIN 2-RELATED NEURONAL VESICLE TRAFFICKING-ASSOCIATED PROTEIN 2 intracellular protein localization#GO:0008104;protein transport#GO:0015031;regulation of biological quality#GO:0065008;localization#GO:0051179;macromolecule metabolic process#GO:0043170;establishment of localization#GO:0051234;cellular localization#GO:0051641;transport#GO:0006810;metabolic process#GO:0008152;regulation of postsynaptic membrane neurotransmitter receptor levels#GO:0099072;biological regulation#GO:0065007;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule localization#GO:0033036 postsynapse#GO:0098794;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;dendrite#GO:0030425;postsynaptic membrane#GO:0045211;endosome#GO:0005768;intracellular organelle#GO:0043229;dendritic tree#GO:0097447;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;early endosome#GO:0005769;membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005;glutamatergic synapse#GO:0098978;endomembrane system#GO:0012505;late endosome#GO:0005770;plasma membrane region#GO:0098590;cytoplasm#GO:0005737;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;synaptic membrane#GO:0097060;cell junction#GO:0030054 HUMAN|HGNC=9556|UniProtKB=O00231 O00231 PSMD11 PTHR10678:SF2 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11 structural molecule activity#GO:0005198;protein complex scaffold activity#GO:0140378 primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511 proteasome regulatory particle, lid subcomplex#GO:0008541;endopeptidase complex#GO:1905369;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;proteasome complex#GO:0000502;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;peptidase complex#GO:1905368 Ubiquitin proteasome pathway#P00060>26S proteasome#P01489;Cell cycle#P00013>Proteasome#P00480 HUMAN|HGNC=947|UniProtKB=Q9UQB8 Q9UQB8 BAIAP2 PTHR14206:SF3 BRAIN-SPECIFIC ANGIOGENESIS INHIBITOR 1-ASSOCIATED PROTEIN 2 BAR_IMD DOMAIN-CONTAINING ADAPTER PROTEIN 2 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 regulation of actin filament-based process#GO:0032970;actin filament organization#GO:0007015;regulation of actin filament organization#GO:0110053;positive regulation of cellular process#GO:0048522;biological regulation#GO:0065007;regulation of actin polymerization or depolymerization#GO:0008064;regulation of actin filament polymerization#GO:0030833;positive regulation of protein polymerization#GO:0032273;actin filament-based process#GO:0030029;supramolecular fiber organization#GO:0097435;regulation of supramolecular fiber organization#GO:1902903;actin filament bundle assembly#GO:0051017;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;regulation of protein polymerization#GO:0032271;regulation of cytoskeleton organization#GO:0051493;regulation of anatomical structure size#GO:0090066;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;regulation of actin cytoskeleton organization#GO:0032956;cytoskeleton organization#GO:0007010;positive regulation of cellular component biogenesis#GO:0044089;cellular component assembly#GO:0022607;regulation of actin filament length#GO:0030832;positive regulation of cellular component organization#GO:0051130;regulation of biological quality#GO:0065008;positive regulation of organelle organization#GO:0010638;regulation of organelle organization#GO:0033043;actin filament bundle organization#GO:0061572;regulation of biological process#GO:0050789;regulation of cellular component size#GO:0032535;cellular component organization#GO:0016043;regulation of protein-containing complex assembly#GO:0043254;regulation of cellular component biogenesis#GO:0044087;regulation of cellular component organization#GO:0051128 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HUMAN|HGNC=23644|UniProtKB=A2A2Z9 A2A2Z9 ANKRD18B PTHR24147:SF59 ANKYRIN REPEAT DOMAIN 36-RELATED ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 18B HUMAN|HGNC=2226|UniProtKB=Q9Y215 Q9Y215 COLQ PTHR24023:SF861 COLLAGEN ALPHA ACETYLCHOLINESTERASE COLLAGENIC TAIL PEPTIDE structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201;heparin binding#GO:0008201;carbohydrate derivative binding#GO:0097367;glycosaminoglycan binding#GO:0005539;binding#GO:0005488 cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;external encapsulating structure organization#GO:0045229;extracellular structure organization#GO:0043062;cellular component organization#GO:0016043;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576 extracellular matrix structural protein#PC00103;extracellular matrix protein#PC00102 HUMAN|HGNC=642|UniProtKB=O94778 O94778 AQP8 PTHR45665:SF66 AQUAPORIN-8 AQUAPORIN-8 channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;water channel activity#GO:0015250;water transmembrane transporter activity#GO:0005372;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 transport#GO:0006810;localization#GO:0051179;water transport#GO:0006833;establishment of localization#GO:0051234;fluid transport#GO:0042044 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HUMAN|HGNC=2254|UniProtKB=Q9ULV4 Q9ULV4 CORO1C PTHR10856:SF10 CORONIN CORONIN-1C protein-containing complex binding#GO:0044877;protein binding#GO:0005515;actin filament binding#GO:0051015;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;binding#GO:0005488 actin filament organization#GO:0007015;mesenchyme development#GO:0060485;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;animal organ development#GO:0048513;neural crest cell differentiation#GO:0014033;developmental process#GO:0032502;mesenchymal cell differentiation#GO:0048762;cytoskeleton organization#GO:0007010;tissue development#GO:0009888;cell migration#GO:0016477;neural crest cell development#GO:0014032;neural crest cell migration#GO:0001755;cellular process#GO:0009987;organelle organization#GO:0006996;stem cell differentiation#GO:0048863;supramolecular fiber organization#GO:0097435;anatomical structure development#GO:0048856;actin filament-based process#GO:0030029;stem cell development#GO:0048864;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;cell differentiation#GO:0030154;actin cytoskeleton organization#GO:0030036;cell motility#GO:0048870;cellular component organization#GO:0016043 cell periphery#GO:0071944;cell leading edge#GO:0031252;membrane#GO:0016020;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;supramolecular complex#GO:0099080;lamellipodium#GO:0030027;supramolecular polymer#GO:0099081;actin filament#GO:0005884;cytoskeleton#GO:0005856;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;actin cytoskeleton#GO:0015629;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622 non-motor actin binding protein#PC00165;cytoskeletal protein#PC00085 HUMAN|HGNC=17728|UniProtKB=Q8TBY8 Q8TBY8 PMFBP1 PTHR18881:SF2 POLYAMINE-MODULATED FACTOR 1-BINDING PROTEIN 1-RELATED POLYAMINE-MODULATED FACTOR 1-BINDING PROTEIN 1 reproductive process#GO:0022414;male gamete generation#GO:0048232;gamete generation#GO:0007276;developmental process involved in reproduction#GO:0003006;multicellular organismal reproductive process#GO:0048609;sexual reproduction#GO:0019953;developmental process#GO:0032502;spermatogenesis#GO:0007283 cellular anatomical structure#GO:0110165 HUMAN|HGNC=14410|UniProtKB=Q9H2U1 Q9H2U1 DHX36 PTHR18934:SF274 ATP-DEPENDENT RNA HELICASE ATP-DEPENDENT DNA_RNA HELICASE DHX36 DNA binding#GO:0003677;RNA binding#GO:0003723;nucleic acid binding#GO:0003676;helicase activity#GO:0004386;isomerase activity#GO:0016853;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;macromolecular conformation isomerase activity#GO:0120543;ATP-dependent activity, acting on DNA#GO:0008094;binding#GO:0005488;ATP-dependent activity#GO:0140657;catalytic activity, acting on DNA#GO:0140097;catalytic activity, acting on RNA#GO:0140098;DNA helicase activity#GO:0003678;nucleic acid conformation isomerase activity#GO:0120545;RNA helicase activity#GO:0003724 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031;RNA helicase#PC00032 HUMAN|HGNC=13646|UniProtKB=Q86VI4 Q86VI4 LAPTM4B PTHR12479:SF6 LYSOSOMAL-ASSOCIATED TRANSMEMBRANE PROTEIN LYSOSOMAL-ASSOCIATED TRANSMEMBRANE PROTEIN 4B regulation of biological quality#GO:0065008;biological regulation#GO:0065007;regulation of membrane permeability#GO:0090559 lysosome#GO:0005764;lytic vacuole membrane#GO:0098852;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;lysosomal membrane#GO:0005765;membrane#GO:0016020;cytoplasm#GO:0005737;vacuole#GO:0005773;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;vacuolar membrane#GO:0005774;lytic vacuole#GO:0000323 transporter#PC00227 HUMAN|HGNC=10946|UniProtKB=Q8WUM9 Q8WUM9 SLC20A1 PTHR11101:SF46 PHOSPHATE TRANSPORTER SODIUM-DEPENDENT PHOSPHATE TRANSPORTER 1 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;secondary active transmembrane transporter activity#GO:0015291;sodium ion transmembrane transporter activity#GO:0015081;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294;symporter activity#GO:0015293;phosphate transmembrane transporter activity#GO:0005315;monoatomic cation transmembrane transporter activity#GO:0008324;solute:sodium symporter activity#GO:0015370 transport#GO:0006810;cellular process#GO:0009987;inorganic anion transport#GO:0015698;phosphate ion transport#GO:0006817;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227 HUMAN|HGNC=16836|UniProtKB=Q8WUH2 Q8WUH2 TGFBRAP1 PTHR12894:SF51 CNH DOMAIN CONTAINING TRANSFORMING GROWTH FACTOR-BETA RECEPTOR-ASSOCIATED PROTEIN 1 organelle fusion#GO:0048284;vesicle-mediated transport#GO:0016192;membrane organization#GO:0061024;vesicle fusion#GO:0006906;organelle membrane fusion#GO:0090174;membrane fusion#GO:0061025;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;localization#GO:0051179;establishment of localization#GO:0051234;vesicle organization#GO:0016050;transport#GO:0006810 endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;vesicle tethering complex#GO:0099023;membrane#GO:0016020;intracellular vesicle#GO:0097708;vesicle#GO:0031982;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=26310|UniProtKB=A0AUZ9 A0AUZ9 KANSL1L PTHR22443:SF16 NON-SPECIFIC LETHAL 1, ISOFORM M KAT8 REGULATORY NSL COMPLEX SUBUNIT 1-LIKE PROTEIN protein binding#GO:0005515;binding#GO:0005488;enzyme binding#GO:0019899 NSL complex#GO:0044545;intracellular anatomical structure#GO:0005622;acetyltransferase complex#GO:1902493;protein acetyltransferase complex#GO:0031248;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;organelle#GO:0043226;chromosome#GO:0005694;membraneless organelle#GO:0043228;intracellular protein-containing complex#GO:0140535;histone acetyltransferase complex#GO:0000123;transferase complex#GO:1990234;H4 histone acetyltransferase complex#GO:1902562;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;chromatin#GO:0000785 HUMAN|HGNC=26261|UniProtKB=Q6UY01 Q6UY01 LRRC31 PTHR24109:SF3 LEUCINE-RICH REPEAT-CONTAINING PROTEIN 31 LEUCINE-RICH REPEAT-CONTAINING PROTEIN 31 HUMAN|HGNC=2954|UniProtKB=Q9UI46 Q9UI46 DNAI1 PTHR12442:SF11 DYNEIN INTERMEDIATE CHAIN DYNEIN AXONEMAL INTERMEDIATE CHAIN 1 binding#GO:0005488;protein binding#GO:0005515 microtubule-based movement#GO:0007018;cell projection organization#GO:0030030;cilium assembly#GO:0060271;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;microtubule cytoskeleton organization#GO:0000226;cilium organization#GO:0044782;axoneme assembly#GO:0035082;organelle assembly#GO:0070925;axonemal dynein complex assembly#GO:0070286;microtubule bundle formation#GO:0001578;cilium movement#GO:0003341;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton organization#GO:0007010;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;outer dynein arm assembly#GO:0036158;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;protein-containing complex organization#GO:0043933;plasma membrane bounded cell projection assembly#GO:0120031 axoneme#GO:0005930;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;catalytic complex#GO:1902494;cilium#GO:0005929;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;axonemal dynein complex#GO:0005858;dynein complex#GO:0030286;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;outer dynein arm#GO:0036157;protein-containing complex#GO:0032991;ciliary plasm#GO:0097014;microtubule associated complex#GO:0005875;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630 microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=26745|UniProtKB=Q8N8C0 Q8N8C0 ZNF781 PTHR14947:SF26 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 781 gene-specific transcriptional regulator#PC00264;zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=1073|UniProtKB=P22004 P22004 BMP6 PTHR11848:SF137 TGF-BETA FAMILY BONE MORPHOGENETIC PROTEIN 6 signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;signaling receptor regulator activity#GO:0030545;cytokine activity#GO:0005125;receptor ligand activity#GO:0048018 multicellular organism development#GO:0007275;animal organ development#GO:0048513;cellular response to BMP stimulus#GO:0071773;developmental process#GO:0032502;response to BMP#GO:0071772;cell surface receptor signaling pathway#GO:0007166;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;biological regulation#GO:0065007;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;heart development#GO:0007507;multicellular organismal process#GO:0032501;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to growth factor stimulus#GO:0071363;system development#GO:0048731;cell communication#GO:0007154;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;animal gross anatomical part developmental process#GO:0160108;signaling#GO:0023052;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;circulatory system development#GO:0072359;response to growth factor#GO:0070848;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;BMP signaling pathway#GO:0030509;response to endogenous stimulus#GO:0009719 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 growth factor#PC00112 Gonadotropin-releasing hormone receptor pathway#P06664>BMP6/7#P06752;TGF-beta signaling pathway#P00052>TGFbeta#P01286 HUMAN|HGNC=18989|UniProtKB=Q8IZF5 Q8IZF5 ADGRF3 PTHR45813:SF2 IG-LIKE DOMAIN-CONTAINING PROTEIN ADHESION G PROTEIN-COUPLED RECEPTOR F3 signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cell communication#GO:0007154 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HUMAN|HGNC=6450|UniProtKB=O76009 O76009 KRT33A PTHR23239:SF98 INTERMEDIATE FILAMENT KERATIN, TYPE I CUTICULAR HA3-I structural molecule activity#GO:0005198 developmental process#GO:0032502;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;morphogenesis of an epithelium#GO:0002009;organelle organization#GO:0006996;cellular process#GO:0009987;epithelium development#GO:0060429;epithelial cell differentiation#GO:0030855;tissue development#GO:0009888;cytoskeleton organization#GO:0007010;intermediate filament-based process#GO:0045103;animal gross anatomical part developmental process#GO:0160108;intermediate filament organization#GO:0045109;tissue morphogenesis#GO:0048729;anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cell differentiation#GO:0030154;intermediate filament cytoskeleton organization#GO:0045104 intracellular anatomical structure#GO:0005622;intermediate filament#GO:0005882;supramolecular fiber#GO:0099512;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;supramolecular complex#GO:0099080;organelle#GO:0043226 intermediate filament#PC00129 HUMAN|HGNC=20452|UniProtKB=Q9Y5U4 Q9Y5U4 INSIG2 PTHR15301:SF10 INSULIN-INDUCED GENE 1 INSULIN-INDUCED GENE 2 PROTEIN primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;response to insulin#GO:0032868;regulation of cellular process#GO:0050794;protein localization to organelle#GO:0033365;regulation of cell communication#GO:0010646;negative regulation of cellular process#GO:0048523;cholesterol metabolic process#GO:0008203;cellular response to insulin stimulus#GO:0032869;regulation of response to stimulus#GO:0048583;secondary alcohol biosynthetic process#GO:1902653;negative regulation of response to stimulus#GO:0048585;lipid biosynthetic process#GO:0008610;biological regulation#GO:0065007;biosynthetic process#GO:0009058;SREBP signaling pathway#GO:0032933;response to peptide hormone#GO:0043434;negative regulation of signaling#GO:0023057;cellular response to chemical stimulus#GO:0070887;regulation of signaling#GO:0023051;cellular localization#GO:0051641;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cellular response to hormone stimulus#GO:0032870;secondary alcohol metabolic process#GO:1902652;alcohol metabolic process#GO:0006066;alcohol biosynthetic process#GO:0046165;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987;cholesterol biosynthetic process#GO:0006695;cellular response to lipid#GO:0071396;negative regulation of signal transduction#GO:0009968;localization#GO:0051179;cell communication#GO:0007154;response to nitrogen compound#GO:1901698;intracellular signal transduction#GO:0035556;cellular response to peptide hormone stimulus#GO:0071375;regulation of response to stress#GO:0080134;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;steroid biosynthetic process#GO:0006694;sterol metabolic process#GO:0016125;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;cellular response to nitrogen compound#GO:1901699;regulation of signal transduction#GO:0009966;regulation of intracellular signal transduction#GO:1902531;response to oxygen-containing compound#GO:1901700;cellular response to stress#GO:0033554;negative regulation of intracellular signal transduction#GO:1902532;regulation of cellular response to stress#GO:0080135;response to endogenous stimulus#GO:0009719;cellular response to endogenous stimulus#GO:0071495;small molecule metabolic process#GO:0044281;signaling#GO:0023052;metabolic process#GO:0008152;response to stress#GO:0006950;response to hormone#GO:0009725;response to chemical#GO:0042221;response to lipid#GO:0033993;sterol biosynthetic process#GO:0016126;steroid metabolic process#GO:0008202 endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;membrane#GO:0016020;organelle membrane#GO:0031090;endoplasmic reticulum protein-containing complex#GO:0140534;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229 HUMAN|HGNC=10307|UniProtKB=P18621 P18621 RPL17 PTHR11593:SF11 60S RIBOSOMAL PROTEIN L17 LARGE RIBOSOMAL SUBUNIT PROTEIN UL22 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;cytoplasmic translation#GO:0002181;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;translation#GO:0006412;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytosolic large ribosomal subunit#GO:0022625;cytosolic ribosome#GO:0022626;cytosol#GO:0005829;ribosome#GO:0005840 ribosomal protein#PC00202 HUMAN|HGNC=23081|UniProtKB=Q8TEB9 Q8TEB9 RHBDD1 PTHR43066:SF14 RHOMBOID-RELATED PROTEIN RHOMBOID-RELATED PROTEIN 4 peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;catalytic activity#GO:0003824;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;serine-type peptidase activity#GO:0008236 cellular process#GO:0009987;negative regulation of programmed cell death#GO:0043069;response to stress#GO:0006950;biological regulation#GO:0065007;negative regulation of apoptotic process#GO:0043066;regulation of apoptotic process#GO:0042981;negative regulation of cellular process#GO:0048523;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;response to topologically incorrect protein#GO:0035966;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to topologically incorrect protein#GO:0035967;cellular response to stress#GO:0033554;cellular response to unfolded protein#GO:0034620;response to unfolded protein#GO:0006986 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 protease#PC00190;serine protease#PC00203;protein modifying enzyme#PC00260 HUMAN|HGNC=7941|UniProtKB=P23582 P23582 NPPC PTHR12167:SF2 C-TYPE NATRIURETIC PEPTIDE C-TYPE NATRIURETIC PEPTIDE molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;hormone activity#GO:0005179;molecular function activator activity#GO:0140677;protein binding#GO:0005515;binding#GO:0005488;hormone receptor binding#GO:0051427;signaling receptor binding#GO:0005102 nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative biosynthetic process#GO:1901137;cell surface receptor signaling pathway#GO:0007166;cyclic purine nucleotide metabolic process#GO:0052652;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;receptor guanylyl cyclase signaling pathway#GO:0007168;signal transduction#GO:0007165;ribose phosphate biosynthetic process#GO:0046390;nucleotide biosynthetic process#GO:0009165;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;cyclic nucleotide biosynthetic process#GO:0009190;ribonucleotide metabolic process#GO:0009259;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;signaling#GO:0023052;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;regulation of biological process#GO:0050789;phosphorus metabolic process#GO:0006793;nucleoside phosphate biosynthetic process#GO:1901293;cyclic nucleotide metabolic process#GO:0009187;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;cGMP metabolic process#GO:0046068;carbohydrate derivative metabolic process#GO:1901135;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;organophosphate biosynthetic process#GO:0090407;enzyme-linked receptor protein signaling pathway#GO:0007167;cGMP biosynthetic process#GO:0006182;cell communication#GO:0007154;nucleoside phosphate metabolic process#GO:0006753;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238 peptide hormone#PC00179 Gonadotropin-releasing hormone receptor pathway#P06664>CNP#G06905;Gonadotropin-releasing hormone receptor pathway#P06664>CNP#P06824;Gonadotropin-releasing hormone receptor pathway#P06664>CNP#G06690 HUMAN|HGNC=2410|UniProtKB=P07315 P07315 CRYGC PTHR11818:SF32 BETA/GAMMA CRYSTALLIN GAMMA-CRYSTALLIN C structural molecule activity#GO:0005198 developmental process#GO:0032502;lens development in camera-type eye#GO:0002088;sensory organ development#GO:0007423;system process#GO:0003008;animal organ development#GO:0048513;multicellular organism development#GO:0007275;sensory system development#GO:0048880;multicellular organismal process#GO:0032501;nervous system process#GO:0050877;sensory perception#GO:0007600;animal gross anatomical part developmental process#GO:0160108;camera-type eye development#GO:0043010;eye development#GO:0001654;system development#GO:0048731;anatomical structure development#GO:0048856;sensory perception of light stimulus#GO:0050953;visual system development#GO:0150063;visual perception#GO:0007601 structural protein#PC00211 HUMAN|HGNC=20859|UniProtKB=Q96H72 Q96H72 SLC39A13 PTHR16950:SF16 ZINC TRANSPORTER SLC39A7 HISTIDINE-RICH MEMBRANE PROTEIN KE4 ZINC TRANSPORTER ZIP13 transition metal ion transmembrane transporter activity#GO:0046915;zinc ion transmembrane transporter activity#GO:0005385;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;monoatomic cation transmembrane transporter activity#GO:0008324 metal ion transport#GO:0030001;homeostatic process#GO:0042592;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;inorganic ion homeostasis#GO:0098771;transition metal ion transport#GO:0000041;zinc ion transmembrane transport#GO:0071577;monoatomic ion transmembrane transport#GO:0034220;zinc ion transport#GO:0006829;monoatomic cation transmembrane transport#GO:0098655;cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;establishment of localization#GO:0051234;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;chemical homeostasis#GO:0048878 organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;membrane#GO:0016020 transporter#PC00227;primary active transporter#PC00068 HUMAN|HGNC=20804|UniProtKB=Q96B54 Q96B54 ZNF428 PTHR36862:SF1 ZINC FINGER PROTEIN 428 ZINC FINGER PROTEIN 428 HUMAN|HGNC=28697|UniProtKB=Q8N4Q0 Q8N4Q0 PTGR3 PTHR43677:SF13 SHORT-CHAIN DEHYDROGENASE/REDUCTASE PROSTAGLANDIN REDUCTASE 3 catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;oxidoreductase activity#GO:0016491 oxidoreductase#PC00176 HUMAN|HGNC=30322|UniProtKB=Q8N1W1 Q8N1W1 ARHGEF28 PTHR13944:SF22 AGAP007712-PA RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 28 GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 regulation of response to stimulus#GO:0048583;regulation of small GTPase mediated signal transduction#GO:0051056;signal transduction#GO:0007165;cellular process#GO:0009987;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;intracellular signaling cassette#GO:0141124;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of Rho protein signal transduction#GO:0035023;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of cell communication#GO:0010646 CCKR signaling map#P06959>p190RhoGEF#P07157 HUMAN|HGNC=16753|UniProtKB=P30041 P30041 PRDX6 PTHR43503:SF11 MCG48959-RELATED PEROXIREDOXIN-6 oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on peroxide as acceptor#GO:0016684;antioxidant activity#GO:0016209;peroxidase activity#GO:0004601;catalytic activity#GO:0003824 cellular homeostasis#GO:0019725;homeostatic process#GO:0042592;cell redox homeostasis#GO:0045454 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 peroxidase#PC00180;oxidoreductase#PC00176 HUMAN|HGNC=21162|UniProtKB=Q495X7 Q495X7 TRIM60 PTHR24103:SF304 E3 UBIQUITIN-PROTEIN LIGASE TRIM TRIPARTITE MOTIF-CONTAINING PROTEIN 60 transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659 immune system process#GO:0002376;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;innate immune response#GO:0045087;regulation of biosynthetic process#GO:0009889;response to external stimulus#GO:0009605;defense response#GO:0006952;regulation of gene expression#GO:0010468;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;immune response#GO:0006955;defense response to symbiont#GO:0140546;defense response to other organism#GO:0098542;biological regulation#GO:0065007;response to other organism#GO:0051707 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=3492|UniProtKB=P41162 P41162 ETV3 PTHR11849:SF30 ETS ETS TRANSLOCATION VARIANT 3 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 winged helix/forkhead transcription factor#PC00246;DNA-binding transcription factor#PC00218 PDGF signaling pathway#P00047>Ets#P01167 HUMAN|HGNC=11491|UniProtKB=P43405 P43405 SYK PTHR24418:SF231 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE SYK catalytic activity#GO:0003824;transferase activity#GO:0016740;protein tyrosine kinase activity#GO:0004713;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 leukocyte activation#GO:0045321;positive regulation of cell adhesion#GO:0045785;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of cell adhesion mediated by integrin#GO:0033628;immune response-activating cell surface receptor signaling pathway#GO:0002429;cell activation#GO:0001775;regulation of immune response#GO:0050776;cell communication#GO:0007154;immune response#GO:0006955;positive regulation of cellular process#GO:0048522;regulation of cell adhesion#GO:0030155;multicellular organismal process#GO:0032501;positive regulation of response to stimulus#GO:0048584;adaptive immune response#GO:0002250;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;macrophage activation#GO:0042116;immune response-regulating signaling pathway#GO:0002764;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signaling#GO:0023052;immune system process#GO:0002376;cell activation involved in immune response#GO:0002263;positive regulation of immune system process#GO:0002684;cellular process#GO:0009987;B cell receptor signaling pathway#GO:0050853;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;activation of immune response#GO:0002253;antigen receptor-mediated signaling pathway#GO:0050851;myeloid leukocyte activation#GO:0002274;leukocyte activation involved in immune response#GO:0002366;cell surface receptor signaling pathway#GO:0007166;immune effector process#GO:0002252;immune response-activating signaling pathway#GO:0002757 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 non-receptor tyrosine protein kinase#PC00168 B cell activation#P00010>Syk#P00382 HUMAN|HGNC=26366|UniProtKB=Q17R55 Q17R55 FAM187B PTHR32178:SF8 FAM187 PROTEIN FAM187B immunoglobulin superfamily cell adhesion molecule#PC00125 HUMAN|HGNC=21174|UniProtKB=Q5TFG8 Q5TFG8 ZC2HC1B PTHR13555:SF36 C2H2 ZINC FINGER CGI-62-RELATED ZINC FINGER C2HC DOMAIN-CONTAINING PROTEIN 1B C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=15294|UniProtKB=Q8NGP3 Q8NGP3 OR5M9 PTHR48018:SF132 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5M9 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 sensory perception#GO:0007600;nervous system process#GO:0050877;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;sensory perception of smell#GO:0007608;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;multicellular organismal process#GO:0032501 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=8682|UniProtKB=Q9Y5F2 Q9Y5F2 PCDHB11 PTHR24028:SF286 CADHERIN-87A PROTOCADHERIN BETA-11 cell adhesion#GO:0007155;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 cell adhesion molecule#PC00069;cadherin#PC00057 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HUMAN|HGNC=30189|UniProtKB=O43824 O43824 GTPBP6 PTHR10229:SF0 GTP-BINDING PROTEIN HFLX GTP-BINDING PROTEIN 6-RELATED binding#GO:0005488;protein-containing complex binding#GO:0044877;ribosome binding#GO:0043022;ribonucleoprotein complex binding#GO:0043021 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=11873|UniProtKB=Q9NYL9 Q9NYL9 TMOD3 PTHR10901:SF18 TROPOMODULIN TROPOMODULIN-3 protein binding#GO:0005515;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779 striated muscle cell development#GO:0055002;animal gross anatomical part developmental process#GO:0160108;cell differentiation#GO:0030154;cell development#GO:0048468;actomyosin structure organization#GO:0031032;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;anatomical structure morphogenesis#GO:0009653;muscle system process#GO:0003012;cellular component organization or biogenesis#GO:0071840;anatomical structure formation involved in morphogenesis#GO:0048646;striated muscle cell differentiation#GO:0051146;cellular anatomical entity morphogenesis#GO:0032989;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;cellular component assembly involved in morphogenesis#GO:0010927;organelle assembly#GO:0070925;actin filament-based process#GO:0030029;actin cytoskeleton organization#GO:0030036;muscle structure development#GO:0061061;muscle cell development#GO:0055001;muscle cell differentiation#GO:0042692;myofibril assembly#GO:0030239;cellular developmental process#GO:0048869;system process#GO:0003008;actin filament organization#GO:0007015;developmental process#GO:0032502;muscle contraction#GO:0006936;multicellular organismal process#GO:0032501 cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;actin cytoskeleton#GO:0015629;contractile muscle fiber#GO:0043292;membraneless organelle#GO:0043228;myofibril#GO:0030016;sarcomere#GO:0030017;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=28944|UniProtKB=A0A087WVF3 A0A087WVF3 TBC1D3D PTHR22957:SF571 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN TBC1 DOMAIN FAMILY MEMBER 3-RELATED enzyme activator activity#GO:0008047;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772 G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HUMAN|HGNC=2736|UniProtKB=Q96FC9 Q96FC9 DDX11 PTHR11472:SF41 DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER ATP-DEPENDENT DNA HELICASE DDX11-RELATED ATP-dependent activity#GO:0140657;ATP-dependent activity, acting on DNA#GO:0008094;macromolecular conformation isomerase activity#GO:0120543;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;DNA helicase activity#GO:0003678;isomerase activity#GO:0016853;helicase activity#GO:0004386;catalytic activity, acting on DNA#GO:0140097 cell cycle#GO:0007049;organelle organization#GO:0006996;cellular component organization#GO:0016043;cell cycle process#GO:0022402;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;sister chromatid cohesion#GO:0007062;chromosome organization#GO:0051276 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA helicase#PC00011;DNA metabolism protein#PC00009 HUMAN|HGNC=20240|UniProtKB=Q8NAU1 Q8NAU1 FNDC5 PTHR14470:SF5 FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN 5 positive regulation of cell differentiation#GO:0045597;regulation of cell differentiation#GO:0045595;positive regulation of developmental process#GO:0051094;positive regulation of fat cell differentiation#GO:0045600;regulation of cellular process#GO:0050794;regulation of developmental process#GO:0050793;biological regulation#GO:0065007;regulation of biological process#GO:0050789;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;extracellular region#GO:0005576 HUMAN|HGNC=16230|UniProtKB=Q9NUD5 Q9NUD5 ZCCHC3 PTHR22639:SF4 GAG-RELATED PROTEIN ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 3 double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of immune response#GO:0050776;regulation of defense response#GO:0031347;positive regulation of biosynthetic process#GO:0009891;response to virus#GO:0009615;response to nitrogen compound#GO:1901698;positive regulation of signal transduction#GO:0009967;positive regulation of type I interferon production#GO:0032481;cellular response to stimulus#GO:0051716;regulation of macromolecule metabolic process#GO:0060255;positive regulation of cytokine production#GO:0001819;regulation of immune system process#GO:0002682;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;response to external biotic stimulus#GO:0043207;regulation of response to biotic stimulus#GO:0002831;regulation of cell communication#GO:0010646;regulation of response to stress#GO:0080134;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of immune response#GO:0050778;positive regulation of defense response#GO:0031349;regulation of response to stimulus#GO:0048583;regulation of innate immune response#GO:0045088;regulation of biosynthetic process#GO:0009889;response to external stimulus#GO:0009605;positive regulation of response to biotic stimulus#GO:0002833;positive regulation of gene expression#GO:0010628;defense response#GO:0006952;regulation of gene expression#GO:0010468;activation of innate immune response#GO:0002218;regulation of cytokine production#GO:0001817;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;positive regulation of innate immune response#GO:0045089;positive regulation of response to stimulus#GO:0048584;cellular response to nitrogen compound#GO:1901699;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;response to other organism#GO:0051707;cellular response to chemical stimulus#GO:0070887;immune system process#GO:0002376;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of signaling#GO:0023056;defense response to virus#GO:0051607;regulation of biological process#GO:0050789;positive regulation of multicellular organismal process#GO:0051240;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;positive regulation of response to external stimulus#GO:0032103;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;positive regulation of immune system process#GO:0002684;positive regulation of pattern recognition receptor signaling pathway#GO:0062208;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;cellular process#GO:0009987;response to chemical#GO:0042221;positive regulation of macromolecule metabolic process#GO:0010604;regulation of response to external stimulus#GO:0032101;regulation of multicellular organismal process#GO:0051239 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 viral or transposable element protein#PC00237 HUMAN|HGNC=15963|UniProtKB=Q15825 Q15825 CHRNA6 PTHR18945:SF82 NEUROTRANSMITTER GATED ION CHANNEL NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-6 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;monoatomic cation channel activity#GO:0005261;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;molecular transducer activity#GO:0060089;channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic ion transmembrane transporter activity#GO:0015075;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion channel activity#GO:0005216;signaling receptor activity#GO:0038023;neurotransmitter receptor activity#GO:0030594;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;acetylcholine receptor activity#GO:0015464;gated channel activity#GO:0022836;postsynaptic neurotransmitter receptor activity#GO:0098960;transmembrane signaling receptor activity#GO:0004888 cellular response to nitrogen compound#GO:1901699;acetylcholine receptor signaling pathway#GO:0095500;synaptic transmission, cholinergic#GO:0007271;monoatomic ion transmembrane transport#GO:0034220;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;transport#GO:0006810;establishment of localization#GO:0051234;chemical synaptic transmission#GO:0007268;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;regulation of cell communication#GO:0010646;membrane depolarization#GO:0051899;metal ion transport#GO:0030001;modulation of chemical synaptic transmission#GO:0050804;trans-synaptic signaling#GO:0099537;monoatomic cation transport#GO:0006812;cell communication#GO:0007154;localization#GO:0051179;response to nitrogen compound#GO:1901698;synaptic signaling#GO:0099536;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;regulation of trans-synaptic signaling#GO:0099177;response to chemical#GO:0042221;neuromuscular synaptic transmission#GO:0007274;regulation of membrane potential#GO:0042391;calcium ion transport#GO:0006816;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signaling#GO:0023052;cellular response to chemical stimulus#GO:0070887;regulation of signaling#GO:0023051;response to oxygen-containing compound#GO:1901700;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008 plasma membrane#GO:0005886;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane region#GO:0098590;cell periphery#GO:0071944;membrane#GO:0016020;transporter complex#GO:1990351;cell junction#GO:0030054;signaling receptor complex#GO:0043235;synaptic membrane#GO:0097060;synapse#GO:0045202;cellular anatomical structure#GO:0110165;plasma membrane protein complex#GO:0098797;postsynapse#GO:0098794;membrane protein complex#GO:0098796;transmembrane transporter complex#GO:1902495;postsynaptic membrane#GO:0045211 ligand-gated ion channel#PC00141 Nicotine pharmacodynamics pathway#P06587>CHRNA6#P06592;Nicotinic acetylcholine receptor signaling pathway#P00044>alpha#P01088;Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086 HUMAN|HGNC=25983|UniProtKB=Q6NUQ4 Q6NUQ4 TMEM214 PTHR13448:SF0 TRANSMEMBRANE PROTEIN 214 TRANSMEMBRANE PROTEIN 214 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 HUMAN|HGNC=11050|UniProtKB=P31645 P31645 SLC6A4 PTHR11616:SF105 SODIUM/CHLORIDE DEPENDENT TRANSPORTER SODIUM-DEPENDENT SEROTONIN TRANSPORTER transporter activity#GO:0005215;monoatomic anion transmembrane transporter activity#GO:0008509;secondary active transmembrane transporter activity#GO:0015291;monoatomic ion transmembrane transporter activity#GO:0015075;heterocyclic compound binding#GO:1901363;metal ion transmembrane transporter activity#GO:0046873;binding#GO:0005488;symporter activity#GO:0015293;serotonin binding#GO:0051378;monoatomic cation transmembrane transporter activity#GO:0008324;chloride transmembrane transporter activity#GO:0015108;monoamine transmembrane transporter activity#GO:0008504;transmembrane transporter activity#GO:0022857;solute:monoatomic cation symporter activity#GO:0015294;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;ion binding#GO:0043167;small molecule binding#GO:0036094;solute:sodium symporter activity#GO:0015370;cation binding#GO:0043169 establishment of localization in cell#GO:0051649;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;nitrogen compound transport#GO:0071705;monoatomic cation transmembrane transport#GO:0098655;neurotransmitter transport#GO:0006836;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;amino acid transport#GO:0006865;import into cell#GO:0098657;establishment of localization#GO:0051234;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;organic hydroxy compound transport#GO:0015850;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;cellular localization#GO:0051641;transmembrane transport#GO:0055085 cell junction#GO:0030054;membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005;synapse#GO:0045202;cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;cell projection#GO:0042995 primary active transporter#PC00068 5HT3 type receptor mediated signaling pathway#P04375>5HT transporter#P04421;5HT2 type receptor mediated signaling pathway#P04374>5HT transporter#P04417;5HT1 type receptor mediated signaling pathway#P04373>5HT transporter#P04409;5HT4 type receptor mediated signaling pathway#P04376>5HT transporter#P04431 HUMAN|HGNC=14579|UniProtKB=Q9NRW7 Q9NRW7 VPS45 PTHR11679:SF3 VESICLE PROTEIN SORTING-ASSOCIATED VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 45 intracellular protein localization#GO:0008104;protein transport#GO:0015031;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;macromolecule localization#GO:0033036 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;intracellular organelle#GO:0043229;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794 membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=10638|UniProtKB=O14625 O14625 CXCL11 PTHR12015:SF191 SMALL INDUCIBLE CYTOKINE A C-X-C MOTIF CHEMOKINE 11 cytokine#PC00083 HUMAN|HGNC=18586|UniProtKB=Q2TAA8 Q2TAA8 TSNAXIP1 PTHR16306:SF0 TRANSLIN-ASSOCIATED FACTOR X-INTERACTING PROTEIN 1 TRANSLIN-ASSOCIATED FACTOR X-INTERACTING PROTEIN 1 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|Gene=ENH3_HUMAN|UniProtKB=Q9N2J8 Q9N2J8 PTHR10424:SF75 VIRAL ENVELOPE PROTEIN ENDOGENOUS RETROVIRUS GROUP S71 MEMBER 1 ENV POLYPROTEIN-RELATED developmental process#GO:0032502;animal gross anatomical part developmental process#GO:0160108;cell-cell fusion#GO:0140253;striated muscle cell differentiation#GO:0051146;cellular developmental process#GO:0048869;anatomical structure development#GO:0048856;syncytium formation by cell-cell fusion#GO:0000768;cellular process#GO:0009987;muscle cell differentiation#GO:0042692;myoblast fusion#GO:0007520;muscle structure development#GO:0061061;cell differentiation#GO:0030154 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 viral or transposable element protein#PC00237 HUMAN|HGNC=12030|UniProtKB=Q15628 Q15628 TRADD PTHR14913:SF0 TUMOR NECROSIS FACTOR RECEPTOR TYPE 1-ASSOCIATED DEATH DOMAIN PROTEIN TUMOR NECROSIS FACTOR RECEPTOR TYPE 1-ASSOCIATED DEATH DOMAIN PROTEIN protein binding#GO:0005515;signaling adaptor activity#GO:0035591;protein-macromolecule adaptor activity#GO:0030674;protein tyrosine kinase binding#GO:1990782;kinase binding#GO:0019900;binding#GO:0005488;signaling receptor binding#GO:0005102;protein kinase binding#GO:0019901;transmembrane receptor protein tyrosine kinase adaptor activity#GO:0005068;enzyme binding#GO:0019899;molecular adaptor activity#GO:0060090;signaling receptor complex adaptor activity#GO:0030159;receptor tyrosine kinase binding#GO:0030971 apoptotic signaling pathway#GO:0097190;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;extrinsic apoptotic signaling pathway#GO:0097191;cellular response to stimulus#GO:0051716;cell death#GO:0008219;cellular process#GO:0009987;apoptotic process#GO:0006915;signal transduction#GO:0007165;regulation of biological process#GO:0050789;programmed cell death#GO:0012501 protein-containing complex#GO:0032991;signaling receptor complex#GO:0043235 Apoptosis signaling pathway#P00006>TRADD#P00319 HUMAN|HGNC=33109|UniProtKB=Q9Y6R6 Q9Y6R6 ZNF780B PTHR24393:SF145 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 780B nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;DNA-binding transcription activator activity#GO:0001216;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;sequence-specific DNA binding#GO:0043565 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HUMAN|HGNC=22571|UniProtKB=A0A1W2PQL4 A0A1W2PQL4 ZNF722 PTHR24384:SF228 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED ZINC FINGER PROTEIN 479-RELATED sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987 regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA-binding transcription factor#PC00218 HUMAN|HGNC=25163|UniProtKB=Q8N1L9 Q8N1L9 BATF2 PTHR23351:SF11 FOS TRANSCRIPTION FACTOR-RELATED BASIC LEUCINE ZIPPER TRANSCRIPTIONAL FACTOR ATF-LIKE 2 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 basic leucine zipper transcription factor#PC00056 HUMAN|HGNC=14634|UniProtKB=Q13442 Q13442 PDAP1 PTHR22055:SF5 28 KDA HEAT- AND ACID-STABLE PHOSPHOPROTEIN PDGF-ASSOCIATED PROTEIN 28 KDA HEAT- AND ACID-STABLE PHOSPHOPROTEIN cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=1750|UniProtKB=P55287 P55287 CDH11 PTHR24027:SF85 CADHERIN-23 CADHERIN-11 beta-catenin binding#GO:0008013;protein binding#GO:0005515;cell adhesion molecule binding#GO:0050839;binding#GO:0005488 cellular component assembly#GO:0022607;cell migration#GO:0016477;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;cell-cell adhesion#GO:0098609;cellular component organization or biogenesis#GO:0071840;developmental process#GO:0032502;cell-cell junction organization#GO:0045216;cell-cell junction assembly#GO:0007043;cell morphogenesis#GO:0000902;cell junction organization#GO:0034330;cell motility#GO:0048870;anatomical structure morphogenesis#GO:0009653;cell junction assembly#GO:0034329;adherens junction organization#GO:0034332;cellular component organization#GO:0016043;anatomical structure development#GO:0048856;cell adhesion#GO:0007155 membrane protein complex#GO:0098796;cell-cell junction#GO:0005911;membrane#GO:0016020;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cell junction#GO:0030054;extrinsic component of membrane#GO:0019898;extrinsic component of plasma membrane#GO:0019897;adherens junction#GO:0005912;anchoring junction#GO:0070161 cadherin#PC00057;cell adhesion molecule#PC00069 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HUMAN|HGNC=30373|UniProtKB=Q6XZF7 Q6XZF7 DNMBP PTHR22834:SF19 NUCLEAR FUSION PROTEIN FUS2 DYNAMIN-BINDING PROTEIN molecular function regulator activity#GO:0098772;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;guanyl-nucleotide exchange factor activity#GO:0005085 cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cell projection assembly#GO:0030031;cellular process#GO:0009987;cell projection organization#GO:0030030;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;plasma membrane bounded cell projection assembly#GO:0120031;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=20612|UniProtKB=Q9H7E2 Q9H7E2 TDRD3 PTHR13681:SF24 SURVIVAL OF MOTOR NEURON-RELATED-SPLICING FACTOR 30-RELATED TUDOR DOMAIN-CONTAINING PROTEIN 3 RNA binding#GO:0003723;chromatin-protein adaptor activity#GO:0140463;binding#GO:0005488;nucleic acid binding#GO:0003676;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;histone reader activity#GO:0140566 cellular component assembly#GO:0022607;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;chromatin organization#GO:0006325;heterochromatin organization#GO:0070828;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;negative regulation of gene expression, epigenetic#GO:0045814;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;regulatory ncRNA-mediated gene silencing#GO:0031047;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;heterochromatin formation#GO:0031507;siRNA-mediated heterochromatin formation#GO:0141194;regulatory ncRNA-mediated heterochromatin formation#GO:0031048 organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 RNA splicing factor#PC00148 HUMAN|HGNC=26102|UniProtKB=Q9H788 Q9H788 SH2D4A PTHR14388:SF5 T CELL-SPECIFIC ADAPTER PROTEIN TSAD SH2 DOMAIN-CONTAINING PROTEIN 4A protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090 HUMAN|HGNC=5209|UniProtKB=P80365 P80365 HSD11B2 PTHR43313:SF2 SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2 catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614 steroid metabolic process#GO:0008202;lipid metabolic process#GO:0006629;cellular process#GO:0009987;metabolic process#GO:0008152;primary metabolic process#GO:0044238 metabolite interconversion enzyme#PC00262;dehydrogenase#PC00092 HUMAN|HGNC=16448|UniProtKB=Q7L266 Q7L266 ASRGL1 PTHR10188:SF41 L-ASPARAGINASE ISOASPARTYL PEPTIDASE_L-ASPARAGINASE hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;amidase activity#GO:0004040;catalytic activity#GO:0003824;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;catalytic activity, acting on a protein#GO:0140096 carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;proteinogenic amino acid metabolic process#GO:0170039;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;small molecule catabolic process#GO:0044282;amino acid metabolic process#GO:0006520;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;protease#PC00190 HUMAN|HGNC=30391|UniProtKB=Q9UG01 Q9UG01 IFT172 PTHR15722:SF2 IFT140/172-RELATED INTRAFLAGELLAR TRANSPORT PROTEIN 172 HOMOLOG organelle organization#GO:0006996;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;cytoskeleton-dependent intracellular transport#GO:0030705;plasma membrane bounded cell projection organization#GO:0120036;intracellular transport#GO:0046907;transport#GO:0006810;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;cellular component organization#GO:0016043;microtubule-based movement#GO:0007018;cell projection organization#GO:0030030;intraciliary transport#GO:0042073;microtubule-based transport#GO:0099111;cellular localization#GO:0051641;localization#GO:0051179;cilium organization#GO:0044782 cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;cilium#GO:0005929;intraciliary transport particle#GO:0030990;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;axoneme#GO:0005930;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;ciliary plasm#GO:0097014;intraciliary transport particle B#GO:0030992;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;ciliary basal body#GO:0036064;membraneless organelle#GO:0043228 structural protein#PC00211 HUMAN|HGNC=24048|UniProtKB=Q8N6S5 Q8N6S5 ARL6IP6 PTHR28640:SF1 ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 6-INTERACTING PROTEIN 6 ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 6-INTERACTING PROTEIN 6 HUMAN|HGNC=26936|UniProtKB=Q05D32 Q05D32 CTDSPL2 PTHR12210:SF173 DULLARD PROTEIN PHOSPHATASE CTD SMALL PHOSPHATASE-LIKE PROTEIN 2 hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788 protein phosphatase#PC00195 HUMAN|HGNC=10956|UniProtKB=P46721 P46721 SLCO1A2 PTHR11388:SF16 ORGANIC ANION TRANSPORTER SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 1A2 active transmembrane transporter activity#GO:0022804;bile acid transmembrane transporter activity#GO:0015125;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;transporter activity#GO:0005215 lipid localization#GO:0010876;bile acid and bile salt transport#GO:0015721;organic acid transport#GO:0015849;carboxylic acid transport#GO:0046942;transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;organic hydroxy compound transport#GO:0015850;monocarboxylic acid transport#GO:0015718;macromolecule localization#GO:0033036;cellular process#GO:0009987;lipid transport#GO:0006869 basal plasma membrane#GO:0009925;cell periphery#GO:0071944;basolateral plasma membrane#GO:0016323;basal part of cell#GO:0045178;membrane#GO:0016020;plasma membrane#GO:0005886;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165 transporter#PC00227 HUMAN|HGNC=37326|UniProtKB=A8MTI9 A8MTI9 PRSS47P PTHR24256:SF214 TRYPTASE-RELATED SERINE PROTEASE 47-RELATED serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233 cellular process#GO:0009987;proteolysis#GO:0006508;metabolic process#GO:0008152;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 serine protease#PC00203 HUMAN|HGNC=15578|UniProtKB=Q96D71 Q96D71 REPS1 PTHR11216:SF63 EH DOMAIN RALBP1-ASSOCIATED EPS DOMAIN-CONTAINING PROTEIN 1 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 cellular process#GO:0009987;establishment of localization in cell#GO:0051649;endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;transport#GO:0006810;establishment of localization#GO:0051234;cellular localization#GO:0051641;import into cell#GO:0098657;localization#GO:0051179;endosomal transport#GO:0016197 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;membrane#GO:0016020;cell periphery#GO:0071944 membrane traffic protein#PC00150 HUMAN|HGNC=13371|UniProtKB=Q96JQ5 Q96JQ5 MS4A4A PTHR23320:SF177 MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 4A intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 transporter#PC00227 HUMAN|HGNC=15667|UniProtKB=P58546 P58546 MTPN PTHR24189:SF76 MYOTROPHIN MYOTROPHIN cellular component organization#GO:0016043;regulation of protein-containing complex assembly#GO:0043254;regulation of biological process#GO:0050789;regulation of cellular component size#GO:0032535;regulation of supramolecular fiber organization#GO:1902903;regulation of organelle organization#GO:0033043;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;regulation of protein polymerization#GO:0032271;regulation of cellular process#GO:0050794;regulation of actin filament depolymerization#GO:0030834;regulation of cellular component biogenesis#GO:0044087;regulation of actin filament length#GO:0030832;regulation of biological quality#GO:0065008;regulation of protein-containing complex disassembly#GO:0043244;cellular process#GO:0009987;regulation of actin filament organization#GO:0110053;regulation of actin filament polymerization#GO:0030833;biological regulation#GO:0065007;regulation of actin polymerization or depolymerization#GO:0008064;regulation of actin cytoskeleton organization#GO:0032956;regulation of anatomical structure size#GO:0090066;regulation of actin filament-based process#GO:0032970;cellular component organization or biogenesis#GO:0071840;regulation of protein depolymerization#GO:1901879 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 HUMAN|HGNC=15082|UniProtKB=Q8NGT7 Q8NGT7 OR2A12 PTHR26453:SF50 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2A12 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 nervous system process#GO:0050877;sensory perception#GO:0007600;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;detection of chemical stimulus#GO:0009593;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;response to stimulus#GO:0050896;response to chemical#GO:0042221 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=22219|UniProtKB=Q9HCM3 Q9HCM3 KIAA1549 PTHR21590:SF4 SEA DOMAIN-CONTAINING PROTEIN UPF0606 PROTEIN KIAA1549 HUMAN|HGNC=44152|UniProtKB=H3BV60 H3BV60 TGFBR3L PTHR14002:SF9 ENDOGLIN/TGF-BETA RECEPTOR TYPE III TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE 3-LIKE PROTEIN transmembrane receptor protein kinase activity#GO:0019199;cytokine binding#GO:0019955;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transforming growth factor beta binding#GO:0050431;molecular transducer activity#GO:0060089;glycosaminoglycan binding#GO:0005539;signaling receptor binding#GO:0005102;signaling receptor activity#GO:0038023;transforming growth factor beta receptor activity#GO:0005024;kinase activity#GO:0016301;carbohydrate derivative binding#GO:0097367;transferase activity#GO:0016740;protein kinase activity#GO:0004672;protein binding#GO:0005515;growth factor binding#GO:0019838;transmembrane receptor protein serine/threonine kinase activity#GO:0004675;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane signaling receptor activity#GO:0004888;protein serine/threonine kinase activity#GO:0004674;cytokine receptor binding#GO:0005126;binding#GO:0005488 animal organ development#GO:0048513;mesenchymal cell differentiation#GO:0048762;cell surface receptor signaling pathway#GO:0007166;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;signal transduction#GO:0007165;cellular process#GO:0009987;transforming growth factor beta receptor signaling pathway#GO:0007179;cellular response to growth factor stimulus#GO:0071363;regulation of signaling#GO:0023051;animal gross anatomical part developmental process#GO:0160108;signaling#GO:0023052;response to stimulus#GO:0050896;cell differentiation#GO:0030154;cellular response to endogenous stimulus#GO:0071495;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;mesenchyme development#GO:0060485;cellular developmental process#GO:0048869;developmental process#GO:0032502;regulation of response to stimulus#GO:0048583;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;regulation of signal transduction#GO:0009966;regulation of cellular response to growth factor stimulus#GO:0090287;biological regulation#GO:0065007;tissue development#GO:0009888;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;response to transforming growth factor beta#GO:0071559;regulation of cell communication#GO:0010646;response to growth factor#GO:0070848;regulation of cellular process#GO:0050794;regulation of transforming growth factor beta receptor signaling pathway#GO:0017015;cellular response to transforming growth factor beta stimulus#GO:0071560;cellular response to stimulus#GO:0051716;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092 transmembrane signal receptor#PC00197 HUMAN|HGNC=850|UniProtKB=P48047 P48047 ATP5PO PTHR11910:SF1 ATP SYNTHASE DELTA CHAIN ATP SYNTHASE PERIPHERAL STALK SUBUNIT OSCP, MITOCHONDRIAL proton-transporting ATP synthase activity, rotational mechanism#GO:0046933;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;proton channel activity#GO:0015252;monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;ligase activity#GO:0016874;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;catalytic activity#GO:0003824;proton transmembrane transporter activity#GO:0015078;passive transmembrane transporter activity#GO:0022803 ribonucleotide metabolic process#GO:0009259;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;nucleotide biosynthetic process#GO:0009165;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521;proton motive force-driven mitochondrial ATP synthesis#GO:0042776;purine nucleotide metabolic process#GO:0006163;small molecule metabolic process#GO:0044281;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;ATP biosynthetic process#GO:0006754;ribonucleoside triphosphate biosynthetic process#GO:0009201;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;ribose phosphate biosynthetic process#GO:0046390;ATP metabolic process#GO:0046034;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;organophosphate biosynthetic process#GO:0090407;cellular respiration#GO:0045333;oxidative phosphorylation#GO:0006119;aerobic respiration#GO:0009060;primary metabolic process#GO:0044238;purine nucleoside triphosphate metabolic process#GO:0009144;purine nucleoside triphosphate biosynthetic process#GO:0009145;nucleoside phosphate metabolic process#GO:0006753;nucleoside triphosphate metabolic process#GO:0009141;proton motive force-driven ATP synthesis#GO:0015986;generation of precursor metabolites and energy#GO:0006091;energy derivation by oxidation of organic compounds#GO:0015980;nucleoside phosphate biosynthetic process#GO:1901293;nucleoside triphosphate biosynthetic process#GO:0009142;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;purine ribonucleoside triphosphate metabolic process#GO:0009205;carbohydrate derivative metabolic process#GO:1901135;purine ribonucleoside triphosphate biosynthetic process#GO:0009206;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739 transporter#PC00227;primary active transporter#PC00068;ATP synthase#PC00002 HUMAN|HGNC=28375|UniProtKB=Q8WWF8 Q8WWF8 CAPSL PTHR34524:SF5 CALCYPHOSIN CALCYPHOSIN-LIKE PROTEIN calcium-binding protein#PC00060;calmodulin-related#PC00061 HUMAN|HGNC=14823|UniProtKB=Q8NGX8 Q8NGX8 OR6Y1 PTHR26453:SF109 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 6Y1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 response to chemical#GO:0042221;response to stimulus#GO:0050896;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;detection of chemical stimulus#GO:0009593;system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception#GO:0007600;nervous system process#GO:0050877 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=29212|UniProtKB=Q96KM6 Q96KM6 ZNF512B PTHR22979:SF3 ZINC FINGER PROTEIN-RELATED ZINC FINGER PROTEIN 512B HUMAN|HGNC=31823|UniProtKB=Q5T749 Q5T749 KPRP PTHR48148:SF2 KERATINOCYTE PROLINE-RICH PROTEIN KERATINOCYTE PROLINE-RICH PROTEIN HUMAN|HGNC=19235|UniProtKB=Q9NY61 Q9NY61 AATF PTHR15565:SF0 AATF PROTEIN APOPTOSIS ANTAGONIZING TRANSCRIPTION FACTOR PROTEIN AATF RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;ribonucleoprotein complex biogenesis#GO:0022613;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;ribosomal small subunit biogenesis#GO:0042274;gene expression#GO:0010467;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;maturation of SSU-rRNA#GO:0030490;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 small-subunit processome#GO:0032040;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;nucleolus#GO:0005730;preribosome#GO:0030684;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=4821|UniProtKB=O14929 O14929 HAT1 PTHR12046:SF0 HISTONE ACETYLTRANSFERASE TYPE B CATALYTIC SUBUNIT HISTONE ACETYLTRANSFERASE TYPE B CATALYTIC SUBUNIT protein N-acyltransferase activity#GO:0140186;histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;acyltransferase activity#GO:0016746;protein-lysine-acetyltransferase activity#GO:0061733;acetyltransferase activity#GO:0016407;N-acetyltransferase activity#GO:0008080;protein N-acetyltransferase activity#GO:0034212;catalytic activity, acting on a protein#GO:0140096;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity#GO:0003824;transferase activity#GO:0016740 histone modifying enzyme#PC00261;chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=28443|UniProtKB=Q8WUR7 Q8WUR7 C15orf40 PTHR13420:SF7 UPF0235 PROTEIN C15ORF40 UPF0235 PROTEIN C15ORF40 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=14937|UniProtKB=Q96S52 Q96S52 PIGS PTHR21072:SF13 GPI TRANSAMIDASE COMPONENT PIG-S GPI-ANCHOR TRANSAMIDASE COMPONENT PIGS GPI anchored protein biosynthesis#GO:0180046;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152 protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasm#GO:0005737;caspase complex#GO:0008303;peptidase complex#GO:1905368;membrane#GO:0016020;organelle membrane#GO:0031090;endoplasmic reticulum protein-containing complex#GO:0140534;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;transferase complex#GO:1990234;endopeptidase complex#GO:1905369;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827 HUMAN|HGNC=24382|UniProtKB=Q7Z4L0 Q7Z4L0 COX8C PTHR16717:SF2 CYTOCHROME C OXIDASE POLYPEPTIDE VIII CYTOCHROME C OXIDASE SUBUNIT 8C, MITOCHONDRIAL oxidoreductase complex#GO:1990204;membrane#GO:0016020;respiratory chain complex#GO:0098803;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;transporter complex#GO:1990351;membrane protein complex#GO:0098796;mitochondrion#GO:0005739;cytochrome complex#GO:0070069;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transmembrane transporter complex#GO:1902495;respiratory chain complex IV#GO:0045277;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262;oxidase#PC00175 HUMAN|HGNC=29819|UniProtKB=Q9ULH7 Q9ULH7 MRTFB PTHR22793:SF5 MYOCARDIN-RELATED TRANSCRIPTION FACTOR-RELATED MYOCARDIN-RELATED TRANSCRIPTION FACTOR B animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502;anatomical structure development#GO:0048856;cellular developmental process#GO:0048869;muscle cell differentiation#GO:0042692;cellular process#GO:0009987;cell differentiation#GO:0030154;muscle structure development#GO:0061061 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=33716|UniProtKB=Q6UXP7 Q6UXP7 FAM151B PTHR21184:SF3 MENORIN (DENDRITIC BRANCHING PROTEIN) PROTEIN FAM151B cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=13055|UniProtKB=Q5VZL5 Q5VZL5 ZMYM4 PTHR45736:SF5 ZINC FINGER MYM-TYPE PROTEIN ZINC FINGER MYM-TYPE PROTEIN 4 DNA-binding transcription factor#PC00218;zinc finger transcription factor#PC00244 HUMAN|HGNC=16608|UniProtKB=Q9ULZ3 Q9ULZ3 PYCARD PTHR46985:SF2 NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 APOPTOSIS-ASSOCIATED SPECK-LIKE PROTEIN CONTAINING A CARD endopeptidase regulator activity#GO:0061135;peptidase regulator activity#GO:0061134;enzyme regulator activity#GO:0030234;pattern recognition receptor activity#GO:0038187;molecular transducer activity#GO:0060089;molecular function activator activity#GO:0140677;enzyme activator activity#GO:0008047;peptidase activator activity#GO:0016504;signaling receptor activity#GO:0038023;molecular function regulator activity#GO:0098772 inflammatory response#GO:0006954;regulation of immune response#GO:0050776;regulation of defense response#GO:0031347;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;cell death#GO:0008219;cellular response to stimulus#GO:0051716;programmed cell death#GO:0012501;regulation of response to biotic stimulus#GO:0002831;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;positive regulation of immune response#GO:0050778;positive regulation of defense response#GO:0031349;regulation of response to stimulus#GO:0048583;regulation of response to stress#GO:0080134;positive regulation of response to biotic stimulus#GO:0002833;defense response#GO:0006952;regulation of innate immune response#GO:0045088;apoptotic signaling pathway#GO:0097190;positive regulation of innate immune response#GO:0045089;activation of innate immune response#GO:0002218;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;immune system process#GO:0002376;intrinsic apoptotic signaling pathway#GO:0097193;regulation of biological process#GO:0050789;apoptotic process#GO:0006915;signaling#GO:0023052;response to stimulus#GO:0050896;positive regulation of response to external stimulus#GO:0032103;activation of immune response#GO:0002253;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;response to stress#GO:0006950;positive regulation of immune system process#GO:0002684;regulation of response to external stimulus#GO:0032101 cytosol#GO:0005829;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;canonical inflammasome complex#GO:0061702;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 defense/immunity protein#PC00090 HUMAN|HGNC=21398|UniProtKB=Q9BV23 Q9BV23 ABHD6 PTHR43798:SF5 MONOACYLGLYCEROL LIPASE MONOACYLGLYCEROL LIPASE ABHD6 cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane#GO:0005886;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;signaling receptor complex#GO:0043235;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495 lipase#PC00143;hydrolase#PC00121 HUMAN|HGNC=26105|UniProtKB=Q7Z736 Q7Z736 PLEKHH3 PTHR46049:SF5 AGAP003327-PA PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY H MEMBER 3 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HUMAN|HGNC=8981|UniProtKB=Q92569 Q92569 PIK3R3 PTHR10155:SF2 PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;enzyme regulator activity#GO:0030234 response to nitrogen compound#GO:1901698;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;insulin receptor signaling pathway#GO:0008286;response to oxygen-containing compound#GO:1901700;cellular response to chemical stimulus#GO:0070887;cellular response to peptide hormone stimulus#GO:0071375;signaling#GO:0023052;cellular response to hormone stimulus#GO:0032870;regulation of cellular process#GO:0050794;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;response to insulin#GO:0032868;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;cell surface receptor signaling pathway#GO:0007166;cellular response to insulin stimulus#GO:0032869;response to peptide hormone#GO:0043434;biological regulation#GO:0065007;cellular response to nitrogen compound#GO:1901699;response to chemical#GO:0042221;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;response to hormone#GO:0009725 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;membrane protein complex#GO:0098796;membrane#GO:0016020;extrinsic component of membrane#GO:0019898;catalytic complex#GO:1902494;transferase complex#GO:1990234;transferase complex, transferring phosphorus-containing groups#GO:0061695 kinase modulator#PC00140 Hypoxia response via HIF activation#P00030>PI3K#P00823;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>PI3K#P00900;PDGF signaling pathway#P00047>PI3K#P01168;Angiogenesis#P00005>PI3K#P00236;p53 pathway#P00059>PI3K#P04609;Endothelin signaling pathway#P00019>PI3K#P00577;PI3 kinase pathway#P00048>p85#P01202;Integrin signalling pathway#P00034>PI3K#P00936;VEGF signaling pathway#P00056>PI3K#P01413;Axon guidance mediated by netrin#P00009>PI3K#P00363;T cell activation#P00053>PI3K#P01322;p53 pathway feedback loops 2#P04398>PI3K#P04661 HUMAN|HGNC=7952|UniProtKB=Q15818 Q15818 NPTX1 PTHR19277:SF24 PENTRAXIN NEURONAL PENTRAXIN-1 cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;neurogenesis#GO:0022008;cell projection morphogenesis#GO:0048858;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron projection morphogenesis#GO:0048812;neuron differentiation#GO:0030182;developmental process#GO:0032502;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;plasma membrane bounded cell projection organization#GO:0120036;axon development#GO:0061564;neuron projection development#GO:0031175;cellular process#GO:0009987;anatomical structure development#GO:0048856;neuron development#GO:0048666;axonogenesis#GO:0007409;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;cell morphogenesis#GO:0000902;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell development#GO:0048468;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653 scaffold/adaptor protein#PC00226 HUMAN|HGNC=51512|UniProtKB=A6NNV3 A6NNV3 SPDYE16 PTHR31156:SF15 WBSCR19-LIKE PROTEIN SPEEDY PROTEIN E10-RELATED HUMAN|HGNC=14480|UniProtKB=Q9NWU5 Q9NWU5 MRPL22 PTHR13501:SF10 CHLOROPLAST 50S RIBOSOMAL PROTEIN L22-RELATED LARGE RIBOSOMAL SUBUNIT PROTEIN UL22M structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;biosynthetic process#GO:0009058;metabolic process#GO:0008152;translation#GO:0006412;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;membrane-enclosed lumen#GO:0031974;mitochondrial large ribosomal subunit#GO:0005762;membraneless organelle#GO:0043228;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;mitochondrion#GO:0005739;ribosome#GO:0005840;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organellar ribosome#GO:0000313;mitochondrial ribosome#GO:0005761;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759 ribosomal protein#PC00202 HUMAN|HGNC=15588|UniProtKB=Q96C24 Q96C24 SYTL4 PTHR45716:SF4 BITESIZE, ISOFORM I SYNAPTOTAGMIN-LIKE PROTEIN 4 signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515 cellular process#GO:0009987;export from cell#GO:0140352;vesicle-mediated transport#GO:0016192;transport#GO:0006810;secretion by cell#GO:0032940;exocytosis#GO:0006887;localization#GO:0051179;establishment of localization#GO:0051234;secretion#GO:0046903 endomembrane system#GO:0012505;transport vesicle#GO:0030133;cytoplasm#GO:0005737;plasma membrane#GO:0005886;membrane#GO:0016020;secretory vesicle#GO:0099503;cell periphery#GO:0071944;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982 membrane trafficking regulatory protein#PC00151;membrane traffic protein#PC00150 HUMAN|HGNC=2035|UniProtKB=O95500 O95500 CLDN14 PTHR12002:SF99 CLAUDIN CLAUDIN-14 cell junction assembly#GO:0034329;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component assembly#GO:0022607;cell junction organization#GO:0034330;cell-cell junction organization#GO:0045216;cell-cell junction assembly#GO:0007043;cellular component organization or biogenesis#GO:0071840 anchoring junction#GO:0070161;tight junction#GO:0070160;cell junction#GO:0030054;apical junction complex#GO:0043296;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;bicellular tight junction#GO:0005923;cell periphery#GO:0071944;membrane#GO:0016020;cell-cell junction#GO:0005911 cell junction protein#PC00070;tight junction#PC00214 HUMAN|HGNC=27501|UniProtKB=Q7Z3Q1 Q7Z3Q1 SLC46A3 PTHR23507:SF9 ZGC:174356 LYSOSOMAL PROTON-COUPLED STEROID CONJUGATE AND BILE ACID SYMPORTER SLC46A3 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 transmembrane transport#GO:0055085;vacuolar transmembrane transport#GO:0034486;establishment of localization#GO:0051234;localization#GO:0051179;cellular process#GO:0009987;transport#GO:0006810 lytic vacuole membrane#GO:0098852;lysosome#GO:0005764;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;lysosomal membrane#GO:0005765;cytoplasm#GO:0005737;vacuole#GO:0005773;vacuolar membrane#GO:0005774;lytic vacuole#GO:0000323;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588 HUMAN|HGNC=3687|UniProtKB=P31371 P31371 FGF9 PTHR11486:SF28 FIBROBLAST GROWTH FACTOR FIBROBLAST GROWTH FACTOR 9 signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;growth factor activity#GO:0008083;growth factor receptor binding#GO:0070851;fibroblast growth factor receptor binding#GO:0005104;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;binding#GO:0005488;signaling receptor binding#GO:0005102;protein binding#GO:0005515;molecular function activator activity#GO:0140677 response to fibroblast growth factor#GO:0071774;developmental process#GO:0032502;positive regulation of intracellular signal transduction#GO:1902533;regulation of cell migration#GO:0030334;regulation of response to stimulus#GO:0048583;positive regulation of MAPK cascade#GO:0043410;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;positive regulation of cellular process#GO:0048522;positive regulation of response to stimulus#GO:0048584;multicellular organismal process#GO:0032501;fibroblast growth factor receptor signaling pathway#GO:0008543;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of locomotion#GO:0040012;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cell communication#GO:0007154;regulation of cell motility#GO:2000145;regulation of cell population proliferation#GO:0042127;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;system development#GO:0048731;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;response to growth factor#GO:0070848;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of cell communication#GO:0010646;regulation of MAPK cascade#GO:0043408;cell surface receptor signaling pathway#GO:0007166;multicellular organism development#GO:0007275;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular response to fibroblast growth factor stimulus#GO:0044344;cellular process#GO:0009987;nervous system development#GO:0007399;animal gross anatomical part developmental process#GO:0160108;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;cellular response to growth factor stimulus#GO:0071363;response to endogenous stimulus#GO:0009719;positive regulation of cell population proliferation#GO:0008284;regulation of biological process#GO:0050789;cellular response to endogenous stimulus#GO:0071495;cell differentiation#GO:0030154;response to stimulus#GO:0050896;signaling#GO:0023052 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 intercellular signal molecule#PC00207;growth factor#PC00112 FGF signaling pathway#P00021>FGF#P00623 HUMAN|HGNC=31713|UniProtKB=Q5QGZ9 Q5QGZ9 CLEC12A PTHR46490:SF4 C-TYPE LECTIN DOMAIN FAMILY 12 MEMBER A-RELATED C-TYPE LECTIN DOMAIN FAMILY 12 MEMBER A signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HUMAN|HGNC=1058|UniProtKB=P54132 P54132 BLM PTHR13710:SF163 DNA HELICASE RECQ FAMILY MEMBER RECQ-LIKE DNA HELICASE BLM catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;macromolecular conformation isomerase activity#GO:0120543;helicase activity#GO:0004386;catalytic activity, acting on DNA#GO:0140097;isomerase activity#GO:0016853;3'-5' DNA helicase activity#GO:0043138;DNA helicase activity#GO:0003678;ATP-dependent activity#GO:0140657;ATP-dependent activity, acting on DNA#GO:0008094 cellular component organization#GO:0016043;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;DNA replication#GO:0006260;double-strand break repair via homologous recombination#GO:0000724;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;recombinational repair#GO:0000725;cellular response to stress#GO:0033554;telomere organization#GO:0032200;response to stress#GO:0006950;organelle organization#GO:0006996;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA recombination#GO:0006310;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;chromosome organization#GO:0051276;double-strand break repair#GO:0006302;telomere maintenance#GO:0000723 intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;chromosome#GO:0005694;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232 DNA metabolism protein#PC00009;DNA helicase#PC00011 HUMAN|HGNC=6149|UniProtKB=P11215 P11215 ITGAM PTHR23220:SF130 INTEGRIN ALPHA INTEGRIN ALPHA-M signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cell-cell adhesion#GO:0098609;integrin-mediated signaling pathway#GO:0007229;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cell surface receptor signaling pathway#GO:0007166;cell adhesion#GO:0007155;cell-matrix adhesion#GO:0007160;cell-substrate adhesion#GO:0031589;cell communication#GO:0007154 integrin complex#GO:0008305;signaling receptor complex#GO:0043235;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane protein complex#GO:0098796;membrane#GO:0016020;protein complex involved in cell adhesion#GO:0098636;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797 integrin#PC00126;cell adhesion molecule#PC00069 Integrin signalling pathway#P00034>Integrin alpha#P00941;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Integrin#P00853 HUMAN|HGNC=29468|UniProtKB=Q5T750 Q5T750 KPLCE PTHR35022:SF28 G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN PROTEIN KPLCE HUMAN|HGNC=33764|UniProtKB=Q6ZRT6 Q6ZRT6 PRR23B PTHR31813:SF18 PROLINE-RICH PROTEIN 23B PROLINE-RICH PROTEIN 23B HUMAN|HGNC=28128|UniProtKB=Q6UX40 Q6UX40 TMEM107 PTHR34341:SF1 TRANSMEMBRANE PROTEIN 107 TRANSMEMBRANE PROTEIN 107 cilium organization#GO:0044782;non-motile cilium assembly#GO:1905515;localization#GO:0051179;organelle assembly#GO:0070925;protein localization to cilium#GO:0061512;protein localization to organelle#GO:0033365;cell projection organization#GO:0030030;cellular component organization#GO:0016043;cilium assembly#GO:0060271;intracellular protein localization#GO:0008104;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection assembly#GO:0120031;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component biogenesis#GO:0044085;macromolecule localization#GO:0033036;organelle organization#GO:0006996 membrane-bounded organelle#GO:0043227;ciliary transition zone#GO:0035869;cilium#GO:0005929;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025 HUMAN|HGNC=13044|UniProtKB=P15622 P15622 ZNF250 PTHR24377:SF112 IP01015P-RELATED ZINC FINGER PROTEIN 250 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=10610|UniProtKB=P51671 P51671 CCL11 PTHR12015:SF146 SMALL INDUCIBLE CYTOKINE A EOTAXIN cytokine activity#GO:0005125;binding#GO:0005488;signaling receptor binding#GO:0005102;cytokine receptor binding#GO:0005126;molecular function activator activity#GO:0140677;chemokine receptor binding#GO:0042379;protein binding#GO:0005515;G protein-coupled receptor binding#GO:0001664;chemokine activity#GO:0008009;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772 regulation of cell migration#GO:0030334;leukocyte migration#GO:0050900;leukocyte chemotaxis#GO:0030595;defense response#GO:0006952;response to external stimulus#GO:0009605;myeloid leukocyte migration#GO:0097529;positive regulation of locomotion#GO:0040017;positive regulation of cell migration#GO:0030335;immune response#GO:0006955;positive regulation of cellular process#GO:0048522;response to other organism#GO:0051707;regulation of locomotion#GO:0040012;biological regulation#GO:0065007;cell migration#GO:0016477;chemotaxis#GO:0006935;inflammatory response#GO:0006954;cytokine-mediated signaling pathway#GO:0019221;cell chemotaxis#GO:0060326;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;chemokine-mediated signaling pathway#GO:0070098;cell communication#GO:0007154;regulation of cell motility#GO:2000145;cellular response to stimulus#GO:0051716;locomotion#GO:0040011;cellular response to chemokine#GO:1990869;response to external biotic stimulus#GO:0043207;regulation of cellular process#GO:0050794;cell motility#GO:0048870;cell surface receptor signaling pathway#GO:0007166;humoral immune response#GO:0006959;antimicrobial humoral response#GO:0019730;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;defense response to symbiont#GO:0140546;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;response to chemokine#GO:1990868;defense response to other organism#GO:0098542;granulocyte migration#GO:0097530;response to cytokine#GO:0034097;taxis#GO:0042330;response to chemical#GO:0042221;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;immune system process#GO:0002376;response to peptide#GO:1901652;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;positive regulation of cell motility#GO:2000147;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;granulocyte chemotaxis#GO:0071621;response to stimulus#GO:0050896 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 cytokine#PC00083 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CHK#P00856 HUMAN|HGNC=1080|UniProtKB=P05423 P05423 POLR3D PTHR13408:SF0 DNA-DIRECTED RNA POLYMERASE III DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4 RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;transcription by RNA polymerase III#GO:0006383;macromolecule metabolic process#GO:0043170;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 protein-containing complex#GO:0032991;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;membrane-bounded organelle#GO:0043227;transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;RNA polymerase III complex#GO:0005666;intracellular organelle#GO:0043229 DNA-directed RNA polymerase#PC00019;RNA metabolism protein#PC00031 HUMAN|HGNC=12262|UniProtKB=A0A1B0GX56 A0A1B0GX56 TRDV1 PTHR23267:SF510 IMMUNOGLOBULIN LIGHT CHAIN T CELL RECEPTOR DELTA VARIABLE 1 response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=3761|UniProtKB=O43155 O43155 FLRT2 PTHR45712:SF16 AGAP008170-PA LEUCINE-RICH REPEAT TRANSMEMBRANE PROTEIN FLRT2 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=578|UniProtKB=Q02410 Q02410 APBA1 PTHR12345:SF14 SYNTENIN RELATED AMYLOID-BETA A4 PRECURSOR PROTEIN-BINDING FAMILY A MEMBER 1 peptide binding#GO:0042277;binding#GO:0005488 cell communication#GO:0007154;trans-synaptic signaling#GO:0099537;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;signaling#GO:0023052;anterograde trans-synaptic signaling#GO:0098916;cellular process#GO:0009987;regulation of biological process#GO:0050789;synaptic signaling#GO:0099536;chemical synaptic transmission#GO:0007268 dendrite#GO:0030425;dendritic tree#GO:0097447;intracellular anatomical structure#GO:0005622;postsynapse#GO:0098794;dendritic spine#GO:0043197;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;neuron spine#GO:0044309;plasma membrane bounded cell projection#GO:0120025;cell junction#GO:0030054;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;cytoplasm#GO:0005737 membrane traffic protein#PC00150;membrane trafficking regulatory protein#PC00151 Alzheimer disease-amyloid secretase pathway#P00003>Tip60#P00093;Alzheimer disease-amyloid secretase pathway#P00003>X11alpha#P00084 HUMAN|HGNC=12393|UniProtKB=P53804 P53804 TTC3 PTHR17550:SF6 E3 UBIQUITIN-PROTEIN LIGASE TTC3 E3 UBIQUITIN-PROTEIN LIGASE TTC3 ubiquitin-protein transferase activity#GO:0004842;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746 catabolic process#GO:0009056;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=11940|UniProtKB=Q13470 Q13470 TNK1 PTHR24418:SF263 TYROSINE-PROTEIN KINASE NON-RECEPTOR TYROSINE-PROTEIN KINASE TNK1 phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;catalytic activity, acting on a protein#GO:0140096;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 non-receptor tyrosine protein kinase#PC00168 HUMAN|HGNC=24452|UniProtKB=Q8IU60 Q8IU60 DCP2 PTHR23114:SF17 M7GPPPN-MRNA HYDROLASE M7GPPPN-MRNA HYDROLASE hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;positive regulation of catabolic process#GO:0009896;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;regulation of nucleobase-containing compound metabolic process#GO:0019219;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound catabolic process#GO:0034655;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;nucleic acid catabolic process#GO:0141188;RNA decapping#GO:0110154;regulation of RNA metabolic process#GO:0051252;regulation of RNA stability#GO:0043487;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;positive regulation of mRNA catabolic process#GO:0061014;regulation of mRNA metabolic process#GO:1903311;metabolic process#GO:0008152;mRNA destabilization#GO:0061157;macromolecule catabolic process#GO:0009057;positive regulation of mRNA metabolic process#GO:1903313;positive regulation of macromolecule metabolic process#GO:0010604;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;RNA destabilization#GO:0050779;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of metabolic process#GO:0009893;RNA metabolic process#GO:0016070;regulation of biological quality#GO:0065008;RNA catabolic process#GO:0006401;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;regulation of mRNA stability#GO:0043488;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;P-body#GO:0000932;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;organelle#GO:0043226;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770 HUMAN|HGNC=564|UniProtKB=Q96CW1 Q96CW1 AP2M1 PTHR10529:SF373 AP COMPLEX SUBUNIT MU AP-2 COMPLEX SUBUNIT MU molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;cargo adaptor activity#GO:0140312 intracellular transport#GO:0046907;regulation of postsynaptic membrane neurotransmitter receptor levels#GO:0099072;transport#GO:0006810;Golgi vesicle transport#GO:0048193;vacuolar transport#GO:0007034;vesicle-mediated transport in synapse#GO:0099003;establishment of localization#GO:0051234;import into cell#GO:0098657;receptor-mediated endocytosis#GO:0006898;receptor internalization#GO:0031623;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;biological regulation#GO:0065007;cellular localization#GO:0051641;Golgi to vacuole transport#GO:0006896;localization#GO:0051179;regulation of biological quality#GO:0065008;post-Golgi vesicle-mediated transport#GO:0006892;postsynaptic neurotransmitter receptor internalization#GO:0098884;clathrin-dependent endocytosis#GO:0072583;endocytosis#GO:0006897 clathrin-coated vesicle#GO:0030136;Golgi apparatus#GO:0005794;organelle membrane#GO:0031090;cell periphery#GO:0071944;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;cytosol#GO:0005829;vesicle membrane#GO:0012506;plasma membrane#GO:0005886;endomembrane system#GO:0012505;transport vesicle#GO:0030133;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane coat#GO:0030117;synaptic vesicle#GO:0008021;plasma membrane protein complex#GO:0098797;vesicle#GO:0031982;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;clathrin vesicle coat#GO:0030125;bounding membrane of organelle#GO:0098588;AP-type membrane coat adaptor complex#GO:0030119;clathrin-coated endocytic vesicle#GO:0045334;clathrin-coated vesicle membrane#GO:0030665;cell junction#GO:0030054;presynapse#GO:0098793;secretory vesicle#GO:0099503;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;vesicle coat#GO:0030120;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;coated vesicle#GO:0030135;organelle subcompartment#GO:0031984;endocytic vesicle#GO:0030139;coated membrane#GO:0048475;intracellular vesicle#GO:0097708;clathrin-coated pit#GO:0005905;coated vesicle membrane#GO:0030662;clathrin coat#GO:0030118;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226 membrane traffic protein#PC00150 CCKR signaling map#P06959>AP2M1#P07067 HUMAN|HGNC=19133|UniProtKB=Q96MM7 Q96MM7 HS6ST2 PTHR12812:SF6 HEPARAN SULFATE 6-O-SULFOTRANSFERASE 3 HEPARAN-SULFATE 6-O-SULFOTRANSFERASE 2 transferase activity, transferring sulphur-containing groups#GO:0016782;sulfotransferase activity#GO:0008146;transferase activity#GO:0016740;catalytic activity#GO:0003824 proteoglycan metabolic process#GO:0006029;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;biosynthetic process#GO:0009058;proteoglycan biosynthetic process#GO:0030166;carbohydrate derivative metabolic process#GO:1901135;protein O-linked glycosylation#GO:0006493;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238 transferase#PC00220 HUMAN|HGNC=4806|UniProtKB=P42357 P42357 HAL PTHR10362:SF85 HISTIDINE AMMONIA-LYASE HISTIDINE AMMONIA-LYASE lyase activity#GO:0016829;catalytic activity#GO:0003824 oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;proteinogenic amino acid metabolic process#GO:0170039;amino acid metabolic process#GO:0006520;small molecule catabolic process#GO:0044282;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987 lyase#PC00144 HUMAN|HGNC=21640|UniProtKB=O75954 O75954 TSPAN9 PTHR19282:SF41 TETRASPANIN TETRASPANIN-9 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HUMAN|HGNC=29452|UniProtKB=Q9Y6H3 Q9Y6H3 ATP23 PTHR21711:SF0 MITOCHONDRIAL INNER MEMBRANE PROTEASE MITOCHONDRIAL INNER MEMBRANE PROTEASE ATP23 HOMOLOG cellular component organization#GO:0016043;primary metabolic process#GO:0044238;protein-containing complex assembly#GO:0065003;proteolysis#GO:0006508;protein metabolic process#GO:0019538;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein processing#GO:0016485;gene expression#GO:0010467;protein maturation#GO:0051604;cellular component assembly#GO:0022607;mitochondrion organization#GO:0007005;mitochondrial respiratory chain complex assembly#GO:0033108;biosynthetic process#GO:0009058;metabolic process#GO:0008152;mitochondrial proton-transporting ATP synthase complex assembly#GO:0033615;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-containing complex organization#GO:0043933 metalloprotease#PC00153;protease#PC00190 HUMAN|HGNC=14899|UniProtKB=Q8WXS8 Q8WXS8 ADAMTS14 PTHR13723:SF24 ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 14 metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 metabolic process#GO:0008152;proteolysis#GO:0006508;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;extracellular matrix organization#GO:0030198;protein metabolic process#GO:0019538;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization#GO:0016043 external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 HUMAN|HGNC=2252|UniProtKB=P31146 P31146 CORO1A PTHR10856:SF18 CORONIN CORONIN-1A protein-containing complex binding#GO:0044877;protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;actin filament binding#GO:0051015;actin binding#GO:0003779;binding#GO:0005488 actin filament-based process#GO:0030029;cellular component organization or biogenesis#GO:0071840;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;cell migration#GO:0016477;actin cytoskeleton organization#GO:0030036;cell motility#GO:0048870;cytoskeleton organization#GO:0007010 intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;actin cytoskeleton#GO:0015629;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cytoskeleton#GO:0005856;actin filament#GO:0005884;supramolecular polymer#GO:0099081;lamellipodium#GO:0030027;supramolecular complex#GO:0099080;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;membrane#GO:0016020;cell leading edge#GO:0031252;cell periphery#GO:0071944 cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HUMAN|HGNC=1786|UniProtKB=P49918 P49918 CDKN1C PTHR10265:SF44 CYCLIN-DEPENDENT KINASE INHIBITOR 1 CYCLIN-DEPENDENT KINASE INHIBITOR 1C enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538;enzyme inhibitor activity#GO:0004857;kinase inhibitor activity#GO:0019210;cyclin-dependent protein kinase regulator activity#GO:0019914;protein kinase regulator activity#GO:0019887;cyclin-dependent protein serine/threonine kinase inhibitor activity#GO:0004861;protein kinase inhibitor activity#GO:0004860;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772 regulation of mitotic cell cycle phase transition#GO:1901990;negative regulation of mitotic cell cycle#GO:0045930;regulation of G1/S transition of mitotic cell cycle#GO:2000045;regulation of cellular process#GO:0050794;regulation of cell cycle G1/S phase transition#GO:1902806;regulation of cell cycle#GO:0051726;negative regulation of cell cycle phase transition#GO:1901988;regulation of cell cycle phase transition#GO:1901987;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of cell cycle#GO:0045786;negative regulation of cellular process#GO:0048523;negative regulation of cell cycle process#GO:0010948;negative regulation of mitotic cell cycle phase transition#GO:1901991;regulation of cell cycle process#GO:0010564;biological regulation#GO:0065007;regulation of mitotic cell cycle#GO:0007346 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634 kinase modulator#PC00140;kinase inhibitor#PC00139 HUMAN|HGNC=20704|UniProtKB=Q9BQ90 Q9BQ90 KLHDC3 PTHR46461:SF1 KELCH DOMAIN-CONTAINING PROTEIN 3 KELCH DOMAIN-CONTAINING PROTEIN 3 chromatin binding#GO:0003682;binding#GO:0005488 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=2605|UniProtKB=Q02318 Q02318 CYP27A1 PTHR24291:SF6 CYTOCHROME P450 FAMILY 4 STEROL 26-HYDROXYLASE, MITOCHONDRIAL monooxygenase activity#GO:0004497;steroid hydroxylase activity#GO:0008395;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;oxidoreductase activity#GO:0016491 alcohol metabolic process#GO:0006066;metabolic process#GO:0008152;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;cholesterol metabolic process#GO:0008203;steroid biosynthetic process#GO:0006694;sterol metabolic process#GO:0016125;vitamin D metabolic process#GO:0042359;cellular process#GO:0009987;alcohol biosynthetic process#GO:0046165;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058;steroid metabolic process#GO:0008202;primary metabolic process#GO:0044238;small molecule metabolic process#GO:0044281;secondary alcohol metabolic process#GO:1902652 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739 oxygenase#PC00177;metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 Vitamin D metabolism and pathway#P04396>1alpha-Hydroxylase#P04603 HUMAN|HGNC=9783|UniProtKB=P20339 P20339 RAB5A PTHR24073:SF1129 DRAB5-RELATED RAS-RELATED PROTEIN RAB-5A pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111 regulation of signaling#GO:0023051;protein transport#GO:0015031;regulation of biological quality#GO:0065008;localization#GO:0051179;cellular localization#GO:0051641;regulation of biological process#GO:0050789;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;endocytosis#GO:0006897;transport#GO:0006810;intracellular protein transport#GO:0006886;regulation of synaptic plasticity#GO:0048167;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;regulation of neuronal synaptic plasticity#GO:0048168;import into cell#GO:0098657;establishment of localization#GO:0051234;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;macromolecule localization#GO:0033036;biological regulation#GO:0065007;regulation of trans-synaptic signaling#GO:0099177 intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;synaptic vesicle#GO:0008021;synaptic vesicle membrane#GO:0030672;vesicle#GO:0031982;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;dendrite#GO:0030425;axon#GO:0030424;dendritic tree#GO:0097447;transport vesicle membrane#GO:0030658;endomembrane system#GO:0012505;transport vesicle#GO:0030133;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;membrane#GO:0016020;vesicle membrane#GO:0012506;cell periphery#GO:0071944;organelle membrane#GO:0031090;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;cell projection#GO:0042995;intracellular vesicle#GO:0097708;endocytic vesicle#GO:0030139;early endosome#GO:0005769;exocytic vesicle#GO:0070382;endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;secretory vesicle#GO:0099503;neuron projection#GO:0043005;presynapse#GO:0098793;cell junction#GO:0030054;bounding membrane of organelle#GO:0098588 small GTPase#PC00208;G-protein#PC00020 HUMAN|HGNC=207|UniProtKB=Q9UKF5 Q9UKF5 ADAM29 PTHR11905:SF34 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 29 metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;proteolysis#GO:0006508;metabolic process#GO:0008152;primary metabolic process#GO:0044238;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 metalloprotease#PC00153;protease#PC00190 HUMAN|HGNC=26033|UniProtKB=Q96PZ0 Q96PZ0 PUS7 PTHR13326:SF31 TRNA PSEUDOURIDINE SYNTHASE D PSEUDOURIDYLATE SYNTHASE 7 HOMOLOG intramolecular transferase activity#GO:0016866;catalytic activity#GO:0003824;isomerase activity#GO:0016853 nucleobase-containing compound metabolic process#GO:0006139;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;pseudouridine synthesis#GO:0001522;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;metabolic process#GO:0008152;RNA modification#GO:0009451 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=1767|UniProtKB=P55286 P55286 CDH8 PTHR24027:SF273 CADHERIN-23 CADHERIN-8 binding#GO:0005488;cell adhesion molecule binding#GO:0050839;protein binding#GO:0005515;beta-catenin binding#GO:0008013 cellular process#GO:0009987;cell-cell adhesion#GO:0098609;cellular component biogenesis#GO:0044085;cell migration#GO:0016477;cellular component assembly#GO:0022607;cell-cell junction assembly#GO:0007043;developmental process#GO:0032502;cell-cell junction organization#GO:0045216;cellular component organization or biogenesis#GO:0071840;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;cell junction assembly#GO:0034329;adherens junction organization#GO:0034332;cell junction organization#GO:0034330;cell morphogenesis#GO:0000902;cell motility#GO:0048870;cell adhesion#GO:0007155;anatomical structure development#GO:0048856 extrinsic component of membrane#GO:0019898;cell junction#GO:0030054;extrinsic component of plasma membrane#GO:0019897;adherens junction#GO:0005912;axon terminus#GO:0043679;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;cell-cell junction#GO:0005911;membrane#GO:0016020;neuron projection#GO:0043005;presynapse#GO:0098793;cell periphery#GO:0071944;anchoring junction#GO:0070161;axon#GO:0030424;extracellular region#GO:0005576;synapse#GO:0045202;cellular anatomical structure#GO:0110165;neuron projection terminus#GO:0044306;cell projection#GO:0042995;distal axon#GO:0150034;plasma membrane bounded cell projection#GO:0120025;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797 cadherin#PC00057;cell adhesion molecule#PC00069 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HUMAN|HGNC=12716|UniProtKB=Q8NER1 Q8NER1 TRPV1 PTHR10582:SF17 TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 1 monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic cation channel activity#GO:0005261;metal ion transmembrane transporter activity#GO:0046873;passive transmembrane transporter activity#GO:0022803;transporter activity#GO:0005215;calcium channel activity#GO:0005262;transmembrane transporter activity#GO:0022857;calcium ion transmembrane transporter activity#GO:0015085;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324 cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;calcium ion transport#GO:0006816;inorganic cation import across plasma membrane#GO:0098659;calcium ion transmembrane import into cytosol#GO:0097553;establishment of localization#GO:0051234;import into cell#GO:0098657;calcium ion import#GO:0070509;calcium ion transmembrane transport#GO:0070588;metal ion transport#GO:0030001;inorganic ion import across plasma membrane#GO:0099587;import across plasma membrane#GO:0098739;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227;ion channel#PC00133 HUMAN|Ensembl=ENSG00000281759.1|UniProtKB=A0A0G2JRQ6 A0A0G2JRQ6 PTHR23267:SF452 IMMUNOGLOBULIN LIGHT CHAIN IG-LIKE DOMAIN-CONTAINING PROTEIN response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=32156|UniProtKB=Q8N7C0 Q8N7C0 LRRC52 PTHR46473:SF6 GH08155P LEUCINE-RICH REPEAT-CONTAINING PROTEIN 52 monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;transporter activity#GO:0005215;voltage-gated channel activity#GO:0022832;protein binding#GO:0005515;molecular function activator activity#GO:0140677;monoatomic cation transmembrane transporter activity#GO:0008324;binding#GO:0005488;voltage-gated monoatomic ion channel activity#GO:0005244;voltage-gated potassium channel activity#GO:0005249;potassium channel regulator activity#GO:0015459;gated channel activity#GO:0022836;monoatomic cation channel activity#GO:0005261;molecular function regulator activity#GO:0098772;passive transmembrane transporter activity#GO:0022803;ion channel regulator activity#GO:0099106;transmembrane transporter activity#GO:0022857;potassium ion transmembrane transporter activity#GO:0015079;channel regulator activity#GO:0016247;channel activity#GO:0015267;transmembrane transporter binding#GO:0044325;transporter regulator activity#GO:0141108;potassium channel activity#GO:0005267 voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991 HUMAN|HGNC=25358|UniProtKB=Q96K19 Q96K19 RNF170 PTHR22894:SF1 RING-TYPE DOMAIN-CONTAINING PROTEIN E3 UBIQUITIN-PROTEIN LIGASE RNF170 HUMAN|HGNC=26511|UniProtKB=O14558 O14558 HSPB6 PTHR45640:SF36 HEAT SHOCK PROTEIN HSP-12.2-RELATED HEAT SHOCK PROTEIN BETA-6 protein metabolic process#GO:0019538;protein refolding#GO:0042026;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;protein folding#GO:0006457;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;response to abiotic stimulus#GO:0009628;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;negative regulation of cellular process#GO:0048523;regulation of apoptotic process#GO:0042981;negative regulation of apoptotic process#GO:0043066;gene expression#GO:0010467;protein maturation#GO:0051604;biological regulation#GO:0065007;biosynthetic process#GO:0009058;response to temperature stimulus#GO:0009266;response to heat#GO:0009408;response to stress#GO:0006950;negative regulation of programmed cell death#GO:0043069;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 chaperone#PC00072 HUMAN|HGNC=29441|UniProtKB=Q8NI77 Q8NI77 KIF18A PTHR24115:SF399 KINESIN-RELATED KINESIN-LIKE PROTEIN KIF18A hydrolase activity, acting on acid anhydrides#GO:0016817;cytoskeletal protein binding#GO:0008092;cytoskeletal motor activity#GO:0003774;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP-dependent activity#GO:0140657;plus-end-directed microtubule motor activity#GO:0008574;protein binding#GO:0005515;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;tubulin binding#GO:0015631;macromolecular conformation isomerase activity#GO:0120543;ribonucleoside triphosphate phosphatase activity#GO:0017111;isomerase activity#GO:0016853;polypeptide conformation or assembly isomerase activity#GO:0120544;microtubule binding#GO:0008017;hydrolase activity#GO:0016787;microtubule motor activity#GO:0003777;ATP hydrolysis activity#GO:0016887 nuclear division#GO:0000280;organelle localization#GO:0051640;supramolecular fiber organization#GO:0097435;organelle fission#GO:0048285;cellular component disassembly#GO:0022411;microtubule cytoskeleton organization#GO:0000226;localization#GO:0051179;mitotic nuclear division#GO:0140014;cell cycle process#GO:0022402;nuclear chromosome segregation#GO:0098813;sister chromatid segregation#GO:0000819;cellular component organization#GO:0016043;cell cycle#GO:0007049;protein-containing complex disassembly#GO:0032984;microtubule-based movement#GO:0007018;mitotic cell cycle#GO:0000278;chromosome segregation#GO:0007059;protein-containing complex organization#GO:0043933;chromosome organization#GO:0051276;microtubule-based process#GO:0007017;mitotic cell cycle process#GO:1903047;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;microtubule polymerization or depolymerization#GO:0031109;mitotic sister chromatid segregation#GO:0000070;organelle organization#GO:0006996;chromosome localization#GO:0050000;protein depolymerization#GO:0051261;cytoskeleton organization#GO:0007010;microtubule depolymerization#GO:0007019 spindle microtubule#GO:0005876;microtubule#GO:0005874;spindle midzone#GO:0051233;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;supramolecular fiber#GO:0099512;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;mitotic spindle#GO:0072686;cytoplasmic microtubule#GO:0005881;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;spindle#GO:0005819;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;nucleus#GO:0005634 microtubule or microtubule-binding cytoskeletal protein#PC00157;microtubule binding motor protein#PC00156 HUMAN|HGNC=6238|UniProtKB=Q9NZV8 Q9NZV8 KCND2 PTHR11537:SF265 VOLTAGE-GATED POTASSIUM CHANNEL A-TYPE VOLTAGE-GATED POTASSIUM CHANNEL KCND2 outward rectifier potassium channel activity#GO:0015271;potassium channel activity#GO:0005267;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;transporter activity#GO:0005215;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;metal ion transport#GO:0030001;action potential#GO:0001508;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;transport#GO:0006810;monoatomic ion transmembrane transport#GO:0034220;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;biological regulation#GO:0065007;potassium ion transport#GO:0006813;cellular process#GO:0009987 transmembrane transporter complex#GO:1902495;postsynaptic membrane#GO:0045211;dendrite#GO:0030425;dendritic tree#GO:0097447;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;neuronal cell body#GO:0043025;neuron spine#GO:0044309;plasma membrane bounded cell projection#GO:0120025;membrane protein complex#GO:0098796;postsynapse#GO:0098794;cell body#GO:0044297;plasma membrane protein complex#GO:0098797;dendritic spine#GO:0043197;cell junction#GO:0030054;transporter complex#GO:1990351;cation channel complex#GO:0034703;voltage-gated potassium channel complex#GO:0008076;synaptic membrane#GO:0097060;plasma membrane region#GO:0098590;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944 voltage-gated ion channel#PC00241;ion channel#PC00133 HUMAN|HGNC=24460|UniProtKB=Q7L2H7 Q7L2H7 EIF3M PTHR15350:SF2 COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT M translation factor activity#GO:0180051;translation initiation factor activity#GO:0003743 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;translational initiation#GO:0006413;translation#GO:0006412;metabolic process#GO:0008152;cytoplasmic translational initiation#GO:0002183;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;cytoplasmic translation#GO:0002181;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238 eukaryotic translation initiation factor 3 complex#GO:0005852;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=8067|UniProtKB=Q99567 Q99567 NUP88 PTHR13257:SF0 NUCLEOPORIN NUP84-RELATED NUCLEAR PORE COMPLEX PROTEIN NUP88 nucleobase-containing compound transport#GO:0015931;protein localization to organelle#GO:0033365;RNA localization#GO:0006403;RNA transport#GO:0050658;establishment of RNA localization#GO:0051236;mRNA transport#GO:0051028;localization#GO:0051179;nucleic acid transport#GO:0050657;nuclear transport#GO:0051169;nuclear export#GO:0051168;organelle localization#GO:0051640;ribosome localization#GO:0033750;nucleocytoplasmic transport#GO:0006913;ribosomal small subunit export from nucleus#GO:0000056;biosynthetic process#GO:0009058;macromolecule localization#GO:0033036;import into nucleus#GO:0051170;protein localization to nucleus#GO:0034504;nitrogen compound transport#GO:0071705;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;ribosomal subunit export from nucleus#GO:0000054;RNA export from nucleus#GO:0006405;transport#GO:0006810;establishment of organelle localization#GO:0051656;ribonucleoprotein complex biogenesis#GO:0022613;ribosomal large subunit export from nucleus#GO:0000055;mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;protein transport#GO:0015031;protein import into nucleus#GO:0006606;ribosome biogenesis#GO:0042254;gene expression#GO:0010467;protein export from nucleus#GO:0006611;cellular component biogenesis#GO:0044085;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;intracellular protein transport#GO:0006886 intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;nuclear pore#GO:0005643;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle envelope#GO:0031967;nucleus#GO:0005634;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635 transporter#PC00227 HUMAN|HGNC=13711|UniProtKB=Q8WVV4 Q8WVV4 POF1B PTHR22546:SF0 PREMATURE OVARIAN FAILURE, 1B PROTEIN POF1B cytoskeletal protein binding#GO:0008092;actin filament binding#GO:0051015;actin binding#GO:0003779;binding#GO:0005488;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;actin filament organization#GO:0007015;cell-cell junction organization#GO:0045216;developmental process#GO:0032502;cell-cell junction assembly#GO:0007043;cellular component assembly#GO:0022607;epithelium development#GO:0060429;epithelial cell differentiation#GO:0030855;tissue development#GO:0009888;cytoskeleton organization#GO:0007010;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;animal gross anatomical part developmental process#GO:0160108;actin filament-based process#GO:0030029;cell differentiation#GO:0030154;cell morphogenesis#GO:0000902;cell junction organization#GO:0034330;actin cytoskeleton organization#GO:0030036;cell development#GO:0048468;cell junction assembly#GO:0034329;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653 intracellular membraneless organelle#GO:0043232;supramolecular complex#GO:0099080;bicellular tight junction#GO:0005923;supramolecular polymer#GO:0099081;cell-cell junction#GO:0005911;adherens junction#GO:0005912;cell junction#GO:0030054;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;tight junction#GO:0070160;actin filament#GO:0005884;apical junction complex#GO:0043296;cytoskeleton#GO:0005856;organelle#GO:0043226;cellular anatomical structure#GO:0110165;actin cytoskeleton#GO:0015629;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;intracellular organelle#GO:0043229 HUMAN|HGNC=28489|UniProtKB=Q8NEP7 Q8NEP7 KLHDC9 PTHR47196:SF1 KELCH DOMAIN-CONTAINING PROTEIN 9 KELCH DOMAIN-CONTAINING PROTEIN 9 protein binding#GO:0005515;binding#GO:0005488;cyclin binding#GO:0030332 HUMAN|HGNC=18404|UniProtKB=Q8IZU0 Q8IZU0 FAM9B PTHR19368:SF2 XLR/SCP3/FAM9 PROTEIN FAM9B spermatid development#GO:0007286;sexual reproduction#GO:0019953;spermatid differentiation#GO:0048515;multicellular organismal reproductive process#GO:0048609;anatomical structure development#GO:0048856;germ cell development#GO:0007281;developmental process involved in reproduction#GO:0003006;cell cycle#GO:0007049;cell development#GO:0048468;cellular process involved in reproduction in multicellular organism#GO:0022412;reproductive process#GO:0022414;gamete generation#GO:0007276;cell differentiation#GO:0030154;spermatogenesis#GO:0007283;developmental process#GO:0032502;meiotic cell cycle#GO:0051321;cellular developmental process#GO:0048869;cellular process#GO:0009987;male gamete generation#GO:0048232 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;chromosome#GO:0005694;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;synaptonemal structure#GO:0099086;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;condensed nuclear chromosome#GO:0000794;synaptonemal complex#GO:0000795;membraneless organelle#GO:0043228;condensed chromosome#GO:0000793 HUMAN|HGNC=6649|UniProtKB=Q0VAK6 Q0VAK6 LMOD3 PTHR10901:SF3 TROPOMODULIN LEIOMODIN-3 protein binding#GO:0005515;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;binding#GO:0005488 myofibril assembly#GO:0030239;muscle cell differentiation#GO:0042692;muscle cell development#GO:0055001;actin cytoskeleton organization#GO:0030036;muscle structure development#GO:0061061;actin filament-based process#GO:0030029;cellular component assembly involved in morphogenesis#GO:0010927;organelle assembly#GO:0070925;supramolecular fiber organization#GO:0097435;anatomical structure development#GO:0048856;multicellular organismal process#GO:0032501;developmental process#GO:0032502;muscle contraction#GO:0006936;system process#GO:0003008;actin filament organization#GO:0007015;cellular developmental process#GO:0048869;anatomical structure morphogenesis#GO:0009653;muscle system process#GO:0003012;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;cell development#GO:0048468;actomyosin structure organization#GO:0031032;cell differentiation#GO:0030154;animal gross anatomical part developmental process#GO:0160108;striated muscle cell development#GO:0055002;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;cellular anatomical entity morphogenesis#GO:0032989;striated muscle cell differentiation#GO:0051146;anatomical structure formation involved in morphogenesis#GO:0048646;cellular component organization or biogenesis#GO:0071840 A band#GO:0031672;actin cytoskeleton#GO:0015629;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;M band#GO:0031430;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;myofibril#GO:0030016;contractile muscle fiber#GO:0043292;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;sarcomere#GO:0030017 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=7627|UniProtKB=Q15742 Q15742 NAB2 PTHR12623:SF6 NGFI-A BINDING PROTEIN NGFI-A-BINDING PROTEIN 2 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 Gonadotropin-releasing hormone receptor pathway#P06664>NAB#P06801 HUMAN|HGNC=18294|UniProtKB=Q9BT22 Q9BT22 ALG1 PTHR13036:SF1 BETA1,4 MANNOSYLTRANSFERASE CHITOBIOSYLDIPHOSPHODOLICHOL BETA-MANNOSYLTRANSFERASE hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740;mannosyltransferase activity#GO:0000030;glycosyltransferase activity#GO:0016757 carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111 HUMAN|HGNC=16013|UniProtKB=Q9Y575 Q9Y575 ASB3 PTHR24178:SF21 MOLTING PROTEIN MLT-4 ANKYRIN REPEAT AND SOCS BOX PROTEIN 3 macromolecule localization#GO:0033036;protein localization to organelle#GO:0033365;localization#GO:0051179;protein localization to cilium#GO:0061512;intracellular protein localization#GO:0008104 cilium#GO:0005929;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025 HUMAN|HGNC=13854|UniProtKB=Q969J2 Q969J2 ZKSCAN4 PTHR23226:SF67 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER PROTEIN WITH KRAB AND SCAN DOMAINS 4 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=24829|UniProtKB=Q86SM5 Q86SM5 MRGPRG PTHR11334:SF32 MAS-RELATED G-PROTEIN COUPLED RECEPTOR MAS-RELATED G PROTEIN-COUPLED RECEPTOR MEMBER G signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=2675|UniProtKB=Q9UIK4 Q9UIK4 DAPK2 PTHR24342:SF15 SERINE/THREONINE-PROTEIN KINASE 17 DEATH-ASSOCIATED PROTEIN KINASE 2 protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824 positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;biological regulation#GO:0065007;regulation of apoptotic process#GO:0042981;positive regulation of apoptotic process#GO:0043065;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;regulation of programmed cell death#GO:0043067;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;positive regulation of programmed cell death#GO:0043068;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=26510|UniProtKB=Q96MH6 Q96MH6 TMEM68 PTHR22753:SF14 TRANSMEMBRANE PROTEIN 68 DGAT1_2-INDEPENDENT ENZYME SYNTHESIZING STORAGE LIPIDS cellular anatomical structure#GO:0110165;membrane#GO:0016020 HUMAN|HGNC=24316|UniProtKB=Q9BSH4 Q9BSH4 TACO1 PTHR12532:SF12 TRANSLATIONAL ACTIVATOR OF CYTOCHROME C OXIDASE 1 TRANSLATIONAL ACTIVATOR OF CYTOCHROME C OXIDASE 1 regulation of biosynthetic process#GO:0009889;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;post-transcriptional regulation of gene expression#GO:0010608;positive regulation of macromolecule metabolic process#GO:0010604;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;regulation of macromolecule biosynthetic process#GO:0010556;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of translation#GO:0045727;positive regulation of protein metabolic process#GO:0051247;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=19985|UniProtKB=P53999 P53999 SUB1 PTHR13215:SF0 RNA POLYMERASE II TRANSCRIPTIONAL COACTIVATOR ACTIVATED RNA POLYMERASE II TRANSCRIPTIONAL COACTIVATOR P15 transcription coactivator activity#GO:0003713;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 general transcription factor#PC00259;RNA metabolism protein#PC00031 HUMAN|HGNC=26384|UniProtKB=Q6WRI0 Q6WRI0 IGSF10 PTHR45842:SF2 SYNAPTIC ADHESION-LIKE MOLECULE SALM IMMUNOGLOBULIN SUPERFAMILY MEMBER 10 cell adhesion molecule#PC00069;immunoglobulin superfamily cell adhesion molecule#PC00125 HUMAN|HGNC=7448|UniProtKB=Q13496 Q13496 MTM1 PTHR10807:SF69 MYOTUBULARIN-RELATED MYOTUBULARIN phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;phosphatidylinositol-3,5-bisphosphate phosphatase activity#GO:0106018;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578 negative regulation of macroautophagy#GO:0016242;cellular process#GO:0009987;glycerophospholipid metabolic process#GO:0006650;metabolic process#GO:0008152;regulation of macroautophagy#GO:0016241;regulation of biological process#GO:0050789;phosphate-containing compound metabolic process#GO:0006796;regulation of organelle organization#GO:0033043;negative regulation of biological process#GO:0048519;regulation of autophagy#GO:0010506;phosphorus metabolic process#GO:0006793;negative regulation of metabolic process#GO:0009892;regulation of cellular component biogenesis#GO:0044087;glycerolipid metabolic process#GO:0046486;regulation of cellular component organization#GO:0051128;regulation of autophagosome assembly#GO:2000785;regulation of organelle assembly#GO:1902115;organophosphate metabolic process#GO:0019637;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;phosphatidylinositol metabolic process#GO:0046488;lipid metabolic process#GO:0006629;negative regulation of cellular process#GO:0048523;negative regulation of autophagy#GO:0010507;mitochondrion localization#GO:0051646;regulation of catabolic process#GO:0009894;cellular homeostasis#GO:0019725;lipid modification#GO:0030258;phospholipid dephosphorylation#GO:0046839;negative regulation of organelle organization#GO:0010639;negative regulation of cellular component organization#GO:0051129;primary metabolic process#GO:0044238;phospholipid metabolic process#GO:0006644;homeostatic process#GO:0042592;regulation of cellular process#GO:0050794;phosphatidylinositol dephosphorylation#GO:0046856;organelle localization#GO:0051640;negative regulation of catabolic process#GO:0009895;localization#GO:0051179;dephosphorylation#GO:0016311 membrane#GO:0016020;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 phosphatase#PC00181 HUMAN|HGNC=18211|UniProtKB=Q9NW61 Q9NW61 PLEKHJ1 PTHR22902:SF9 SESQUIPEDALIAN PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY J MEMBER 1 membrane traffic protein#PC00150 HUMAN|HGNC=23226|UniProtKB=Q9BX82 Q9BX82 ZNF471 PTHR24377:SF951 IP01015P-RELATED ZINC FINGER PROTEIN 471 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=25473|UniProtKB=Q9P2N6 Q9P2N6 KANSL3 PTHR13136:SF16 TESTIS DEVELOPMENT PROTEIN PRTD KAT8 REGULATORY NSL COMPLEX SUBUNIT 3 regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522 transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;histone acetyltransferase complex#GO:0000123;membraneless organelle#GO:0043228;chromatin#GO:0000785;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;H4 histone acetyltransferase complex#GO:1902562;protein acetyltransferase complex#GO:0031248;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;acetyltransferase complex#GO:1902493;NSL complex#GO:0044545;chromosome#GO:0005694;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=11523|UniProtKB=O95359 O95359 TACC2 PTHR13924:SF11 TRANSFORMING ACIDIC COILED-COIL CONTAINING PROTEIN 1/2 TRANSFORMING ACIDIC COILED-COIL-CONTAINING PROTEIN 2 transcription factor binding#GO:0008134;nuclear receptor binding#GO:0016922;binding#GO:0005488;RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629;protein binding#GO:0005515;DNA-binding transcription factor binding#GO:0140297 multicellular organism development#GO:0007275;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;establishment of localization#GO:0051234;microtubule-based process#GO:0007017;neurogenesis#GO:0022008;intracellular transport#GO:0046907;developmental process#GO:0032502;transport#GO:0006810;multicellular organismal process#GO:0032501;cytoskeleton organization#GO:0007010;nervous system development#GO:0007399;organelle organization#GO:0006996;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;localization#GO:0051179;cellular localization#GO:0051641;anatomical structure development#GO:0048856;microtubule cytoskeleton organization#GO:0000226;system development#GO:0048731;supramolecular fiber organization#GO:0097435;organelle localization#GO:0051640;animal gross anatomical part developmental process#GO:0160108;cell differentiation#GO:0030154;cytoplasmic microtubule organization#GO:0031122;establishment of organelle localization#GO:0051656;cell cycle#GO:0007049;cellular component organization#GO:0016043;nuclear migration#GO:0007097;cell cycle process#GO:0022402 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630;cytosol#GO:0005829;spindle pole#GO:0000922;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;centrosome#GO:0005813;microtubule organizing center#GO:0005815;spindle#GO:0005819;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 HUMAN|HGNC=21301|UniProtKB=Q5SQH8 Q5SQH8 C6orf136 PTHR31094:SF2 RIKEN CDNA 2310061I04 GENE RIKEN CDNA 2310061I04 GENE HUMAN|HGNC=37176|UniProtKB=A6NCW7 A6NCW7 USP17L4 PTHR24006:SF651 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE INACTIVE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 17-LIKE PROTEIN 4-RELATED catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;cysteine-type deubiquitinase activity#GO:0004843;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005 regulation of apoptotic process#GO:0042981;regulation of biological process#GO:0050789;regulation of protein stability#GO:0031647;regulation of programmed cell death#GO:0043067;regulation of biological quality#GO:0065008;biological regulation#GO:0065007;regulation of cellular process#GO:0050794 nucleus#GO:0005634;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 cysteine protease#PC00081;protease#PC00190 HUMAN|HGNC=44666|UniProtKB=H3BNL1 H3BNL1 CIMIP7 PTHR35539:SF1 CDNA SEQUENCE BC048562 CILIARY MICROTUBULE INNER PROTEIN 7 HUMAN|HGNC=9935|UniProtKB=Q14257 Q14257 RCN2 PTHR10827:SF78 RETICULOCALBIN RETICULOCALBIN-2 metal ion binding#GO:0046872;cation binding#GO:0043169;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;calcium ion binding#GO:0005509 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226 calcium-binding protein#PC00060;calmodulin-related#PC00061 HUMAN|HGNC=1707|UniProtKB=P10966 P10966 CD8B PTHR11292:SF7 T-CELL SURFACE GLYCOPROTEIN CD8 BETA CHAIN T-CELL SURFACE GLYCOPROTEIN CD8 BETA CHAIN-RELATED immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=4075|UniProtKB=P14867 P14867 GABRA1 PTHR18945:SF514 NEUROTRANSMITTER GATED ION CHANNEL GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1 gated channel activity#GO:0022836;transmembrane signaling receptor activity#GO:0004888;ligand-gated monoatomic ion channel activity#GO:0015276;molecular transducer activity#GO:0060089;channel activity#GO:0015267;ligand-gated channel activity#GO:0022834;neurotransmitter receptor activity#GO:0030594;passive transmembrane transporter activity#GO:0022803;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;signaling receptor activity#GO:0038023 monoatomic ion transmembrane transport#GO:0034220;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;transport#GO:0006810;developmental process#GO:0032502;establishment of localization#GO:0051234;chemical synaptic transmission#GO:0007268;monoatomic anion transport#GO:0006820;cell junction organization#GO:0034330;anterograde trans-synaptic signaling#GO:0098916;synapse organization#GO:0050808;trans-synaptic signaling#GO:0099537;system development#GO:0048731;anatomical structure development#GO:0048856;localization#GO:0051179;chloride transmembrane transport#GO:1902476;cell communication#GO:0007154;cellular process#GO:0009987;synaptic signaling#GO:0099536;cellular component biogenesis#GO:0044085;nervous system development#GO:0007399;monoatomic anion transmembrane transport#GO:0098656;cellular component assembly#GO:0022607;chloride transport#GO:0006821;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;cell junction assembly#GO:0034329;signaling#GO:0023052;synapse assembly#GO:0007416;animal gross anatomical part developmental process#GO:0160108;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698;transmembrane transport#GO:0055085 plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;plasma membrane region#GO:0098590;protein-containing complex#GO:0032991;neuron projection#GO:0043005;cell periphery#GO:0071944;cell leading edge#GO:0031252;membrane#GO:0016020;cell junction#GO:0030054;neuron projection membrane#GO:0032589;signaling receptor complex#GO:0043235;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;synapse#GO:0045202;cellular anatomical structure#GO:0110165;postsynapse#GO:0098794;cell projection membrane#GO:0031253;dendritic tree#GO:0097447;leading edge membrane#GO:0031256;dendrite#GO:0030425 ligand-gated ion channel#PC00141 HUMAN|HGNC=6167|UniProtKB=P19823 P19823 ITIH2 PTHR10338:SF14 INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H2 protease inhibitor#PC00191;protein-binding activity modulator#PC00095 HUMAN|HGNC=29068|UniProtKB=O60303 O60303 KATNIP PTHR21534:SF0 KATANIN-INTERACTING PROTEIN KATANIN-INTERACTING PROTEIN HUMAN|HGNC=31953|UniProtKB=A8MZ59 A8MZ59 LEUTX PTHR45793:SF18 HOMEOBOX PROTEIN PAIRED-LIKE HOMEODOMAIN TRANSCRIPTION FACTOR LEUTX RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=26072|UniProtKB=Q8IVU3 Q8IVU3 HERC6 PTHR45622:SF11 UBIQUITIN-PROTEIN LIGASE E3A-RELATED E3 UBIQUITIN-PROTEIN LIGASE HERC6-RELATED transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842 protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;catabolic process#GO:0009056;primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;protein modification by small protein conjugation or removal#GO:0070647;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=15961|UniProtKB=Q9ULV8 Q9ULV8 CBLC PTHR23007:SF12 CBL E3 UBIQUITIN-PROTEIN LIGASE CBL-C acyltransferase activity#GO:0016746;protein tyrosine kinase binding#GO:1990782;signaling receptor binding#GO:0005102;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;receptor tyrosine kinase binding#GO:0030971;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;kinase binding#GO:0019900;binding#GO:0005488;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;ubiquitin protein ligase activity#GO:0061630;protein binding#GO:0005515;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;transferase activity#GO:0016740 negative regulation of response to stimulus#GO:0048585;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;regulation of epidermal growth factor receptor signaling pathway#GO:0042058;signal transduction#GO:0007165;cellular process#GO:0009987;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of cell communication#GO:0010646;negative regulation of biological process#GO:0048519;regulation of ERBB signaling pathway#GO:1901184;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;negative regulation of cell communication#GO:0010648;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane microdomain#GO:0098857;membrane raft#GO:0045121;membrane#GO:0016020 ligase#PC00142 EGF receptor signaling pathway#P00018>c-Cbl#P00544 HUMAN|HGNC=21894|UniProtKB=Q9H875 Q9H875 PRKRIP1 PTHR13507:SF0 PRKR-INTERACTING PROTEIN 1 PRKR-INTERACTING PROTEIN 1 enzyme inhibitor activity#GO:0004857;protein kinase inhibitor activity#GO:0004860;molecular function regulator activity#GO:0098772;double-stranded RNA binding#GO:0003725;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;protein kinase regulator activity#GO:0019887;kinase regulator activity#GO:0019207;kinase inhibitor activity#GO:0019210;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;kinase binding#GO:0019900;binding#GO:0005488;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;protein binding#GO:0005515 intracellular organelle#GO:0043229;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226 HUMAN|HGNC=2772|UniProtKB=O00273 O00273 DFFA PTHR12306:SF16 CELL DEATH ACTIVATOR CIDE DNAATION FACTOR SUBUNIT ALPHA lipid transfer activity#GO:0120013;transporter activity#GO:0005215;lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104 organelle fusion#GO:0048284;negative regulation of apoptotic process#GO:0043066;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of DNA metabolic process#GO:0051053;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;organelle organization#GO:0006996;cellular process#GO:0009987;lipid storage#GO:0019915;negative regulation of programmed cell death#GO:0043069;negative regulation of macromolecule metabolic process#GO:0010605;cellular component organization or biogenesis#GO:0071840;regulation of catabolic process#GO:0009894;negative regulation of cellular process#GO:0048523;regulation of apoptotic process#GO:0042981;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of metabolic process#GO:0009892;cellular component organization#GO:0016043;programmed cell death#GO:0012501;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;cell death#GO:0008219;apoptotic process#GO:0006915;regulation of DNA metabolic process#GO:0051052;regulation of biological process#GO:0050789;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of catabolic process#GO:0009895;lipid droplet organization#GO:0034389 lipid droplet#GO:0005811;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165;chromatin#GO:0000785;chromosome#GO:0005694 HUMAN|HGNC=2901|UniProtKB=Q15700 Q15700 DLG2 PTHR23119:SF6 DISCS LARGE DISKS LARGE HOMOLOG 2 protein binding#GO:0005515;structural constituent of synapse#GO:0098918;kinase binding#GO:0019900;binding#GO:0005488;signaling receptor binding#GO:0005102;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;structural molecule activity#GO:0005198 multicellular organism development#GO:0007275;protein localization to synapse#GO:0035418;cellular process#GO:0009987;cell-cell adhesion#GO:0098609;synaptic signaling#GO:0099536;nervous system development#GO:0007399;cell adhesion#GO:0007155;receptor clustering#GO:0043113;animal gross anatomical part developmental process#GO:0160108;establishment or maintenance of cell polarity#GO:0007163;regulation of biological quality#GO:0065008;cellular localization#GO:0051641;regulation of biological process#GO:0050789;protein localization to membrane#GO:0072657;signaling#GO:0023052;developmental process#GO:0032502;regulation of postsynaptic membrane neurotransmitter receptor levels#GO:0099072;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;multicellular organismal process#GO:0032501;establishment or maintenance of bipolar cell polarity#GO:0061245;localization within membrane#GO:0051668;establishment or maintenance of apical/basal cell polarity#GO:0035088;trans-synaptic signaling#GO:0099537;protein localization to cell junction#GO:1902414;system development#GO:0048731;anatomical structure development#GO:0048856;localization#GO:0051179;establishment or maintenance of epithelial cell apical/basal polarity#GO:0045197;cell communication#GO:0007154;chemical synaptic transmission#GO:0007268;anterograde trans-synaptic signaling#GO:0098916 postsynapse#GO:0098794;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;asymmetric synapse#GO:0032279;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;postsynaptic specialization membrane#GO:0099634;postsynaptic membrane#GO:0045211;postsynaptic density#GO:0014069;postsynaptic density membrane#GO:0098839;membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005;neuron to neuron synapse#GO:0098984;plasma membrane region#GO:0098590;postsynaptic specialization#GO:0099572;plasma membrane#GO:0005886;synaptic membrane#GO:0097060;neuromuscular junction#GO:0031594;cell junction#GO:0030054 scaffold/adaptor protein#PC00226 HUMAN|HGNC=6266|UniProtKB=P48544 P48544 KCNJ5 PTHR11767:SF52 INWARD RECTIFIER POTASSIUM CHANNEL G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 4 transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;monoatomic cation channel activity#GO:0005261;potassium channel activity#GO:0005267;ligand-gated monoatomic ion channel activity#GO:0015276;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079 inorganic cation import across plasma membrane#GO:0098659;import into cell#GO:0098657;establishment of localization#GO:0051234;potassium ion import across plasma membrane#GO:1990573;transport#GO:0006810;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;potassium ion transport#GO:0006813;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;inorganic ion import across plasma membrane#GO:0099587;metal ion transport#GO:0030001;import across plasma membrane#GO:0098739 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GIRK#P00724;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>GIRK#P01083;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GPRK#P00741 HUMAN|HGNC=30574|UniProtKB=Q8TB69 Q8TB69 ZNF519 PTHR24384:SF218 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED ZINC FINGER PROTEIN 519 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218 HUMAN|HGNC=34071|UniProtKB=A6NHN0 A6NHN0 OTOL1 PTHR24023:SF914 COLLAGEN ALPHA OTOLIN-1 structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;extracellular structure organization#GO:0043062;cellular component organization#GO:0016043 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012 extracellular matrix structural protein#PC00103;extracellular matrix protein#PC00102 HUMAN|HGNC=20907|UniProtKB=Q96JC9 Q96JC9 EAF1 PTHR15970:SF8 ELL-ASSOCIATED FACTOR EAF ELL-ASSOCIATED FACTOR 1 transcription elongation factor activity#GO:0003711;transcription regulator activity#GO:0140110 DNA-templated transcription elongation#GO:0006354;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;transcription elongation by RNA polymerase II#GO:0006368;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;transcription by RNA polymerase II#GO:0006366;macromolecule metabolic process#GO:0043170;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070 cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;protein-containing complex#GO:0032991;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;transcription elongation factor complex#GO:0008023;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 HUMAN|HGNC=25478|UniProtKB=Q8N565 Q8N565 MREG PTHR34340:SF3 MELANOREGULIN MELANOREGULIN cellular developmental process#GO:0048869;establishment of localization#GO:0051234;developmental process#GO:0032502;transport#GO:0006810;establishment of vesicle localization#GO:0051650;cellular pigmentation#GO:0033059;vesicle localization#GO:0051648;establishment of localization in cell#GO:0051649;developmental pigmentation#GO:0048066;cellular process#GO:0009987;melanocyte differentiation#GO:0030318;localization#GO:0051179;cellular localization#GO:0051641;pigmentation#GO:0043473;organelle localization#GO:0051640;cell differentiation#GO:0030154;establishment of organelle localization#GO:0051656 intracellular membrane-bounded organelle#GO:0043231;melanosome#GO:0042470;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=2869|UniProtKB=P49366 P49366 DHPS PTHR11703:SF0 DEOXYHYPUSINE SYNTHASE DEOXYHYPUSINE SYNTHASE catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765 metabolic process#GO:0008152;amine metabolic process#GO:0009308;polyamine metabolic process#GO:0006595;cellular process#GO:0009987;biogenic amine metabolic process#GO:0006576 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=4879|UniProtKB=P07686 P07686 HEXB PTHR22600:SF38 BETA-HEXOSAMINIDASE BETA-HEXOSAMINIDASE SUBUNIT BETA hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;lipid metabolic process#GO:0006629;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;glycoprotein biosynthetic process#GO:0009101;lipid catabolic process#GO:0016042;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;biosynthetic process#GO:0009058;aminoglycan metabolic process#GO:0006022;ceramide metabolic process#GO:0006672;protein metabolic process#GO:0019538;sphingolipid catabolic process#GO:0030149;primary metabolic process#GO:0044238;glycosaminoglycan metabolic process#GO:0030203;protein N-linked glycosylation#GO:0006487;catabolic process#GO:0009056;liposaccharide metabolic process#GO:1903509;glycolipid metabolic process#GO:0006664;carbohydrate derivative catabolic process#GO:1901136 lytic vacuole#GO:0000323;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;extracellular region#GO:0005576;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;plasma membrane#GO:0005886;vacuole#GO:0005773;membrane#GO:0016020;cell periphery#GO:0071944;lysosome#GO:0005764 glycosidase#PC00110 HUMAN|HGNC=25603|UniProtKB=Q96AN5 Q96AN5 TMEM143 PTHR16095:SF10 TRANSMEMBRANE PROTEIN 143 FAMILY MEMBER TRANSMEMBRANE PROTEIN 143 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=9082|UniProtKB=O00469 O00469 PLOD2 PTHR10730:SF6 PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE 2 catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;dioxygenase activity#GO:0051213;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491 cellular component organization#GO:0016043;extracellular structure organization#GO:0043062;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;collagen fibril organization#GO:0030199;extracellular matrix organization#GO:0030198;external encapsulating structure organization#GO:0045229 external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;extracellular region#GO:0005576;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HUMAN|HGNC=4187|UniProtKB=P02774 P02774 GC PTHR11385:SF11 SERUM ALBUMIN-RELATED VITAMIN D-BINDING PROTEIN small molecule binding#GO:0036094;binding#GO:0005488;lipid binding#GO:0008289;steroid binding#GO:0005496 vitamin D metabolic process#GO:0042359;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;steroid metabolic process#GO:0008202;response to stimulus#GO:0050896;cellular process#GO:0009987;response to nutrient levels#GO:0031667;primary metabolic process#GO:0044238 transfer/carrier protein#PC00219 Vitamin D metabolism and pathway#P04396>DBP#P04600 HUMAN|HGNC=14050|UniProtKB=P82912 P82912 MRPS11 PTHR11759:SF76 40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11 SMALL RIBOSOMAL SUBUNIT PROTEIN US11M structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;translation#GO:0006412;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;mitochondrion#GO:0005739;ribosome#GO:0005840;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organellar ribosome#GO:0000313;mitochondrial ribosome#GO:0005761;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;small ribosomal subunit#GO:0015935;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;membrane-enclosed lumen#GO:0031974;membraneless organelle#GO:0043228;mitochondrial small ribosomal subunit#GO:0005763 translational protein#PC00263;ribosomal protein#PC00202 HUMAN|HGNC=15072|UniProtKB=Q8NHA6 Q8NHA6 OR2W6P PTHR26453:SF21 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2W6-RELATED transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;response to stimulus#GO:0050896;response to chemical#GO:0042221;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;detection of chemical stimulus#GO:0009593;system process#GO:0003008;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;nervous system process#GO:0050877;sensory perception#GO:0007600 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=7959|UniProtKB=Q99463 Q99463 NPY6RP PTHR24235:SF16 NEUROPEPTIDE Y RECEPTOR NEUROPEPTIDE Y RECEPTOR TYPE 6-RELATED signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;molecular transducer activity#GO:0060089;G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888;neuropeptide receptor activity#GO:0008188 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;neuropeptide signaling pathway#GO:0007218;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052 cell periphery#GO:0071944;neuron projection#GO:0043005;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=21463|UniProtKB=Q99551 Q99551 MTERF1 PTHR15437:SF2 TRANSCRIPTION TERMINATION FACTOR, MITOCHONDRIAL TRANSCRIPTION TERMINATION FACTOR 1, MITOCHONDRIAL DNA binding#GO:0003677;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;sequence-specific DNA binding#GO:0043565;binding#GO:0005488;nucleic acid binding#GO:0003676 DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA metabolic process#GO:0016070;mitochondrial RNA metabolic process#GO:0000959;mitochondrial gene expression#GO:0140053;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;biosynthetic process#GO:0009058;mitochondrial transcription#GO:0006390;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;DNA-templated transcription termination#GO:0006353;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 Transcription regulation by bZIP transcription factor#P00055>TTF2#P01389;General transcription regulation#P00023>TTF2#P00661 HUMAN|HGNC=25330|UniProtKB=Q9P2B4 Q9P2B4 CTTNBP2NL PTHR23166:SF9 FILAMIN/GPBP-INTERACTING PROTEIN CTTNBP2 N-TERMINAL-LIKE PROTEIN intracellular protein localization#GO:0008104;protein localization to organelle#GO:0033365;localization#GO:0051179;protein localization to cytoskeleton#GO:0044380;macromolecule localization#GO:0033036 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;actin cytoskeleton#GO:0015629 HUMAN|HGNC=19318|UniProtKB=Q8IVL6 Q8IVL6 P3H3 PTHR14049:SF14 LEPRECAN 1 PROLYL 3-HYDROXYLASE 3 dioxygenase activity#GO:0051213;catalytic activity, acting on a protein#GO:0140096;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705 cellular process#GO:0009987;metabolic process#GO:0008152 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 extracellular matrix glycoprotein#PC00100 HUMAN|HGNC=25645|UniProtKB=Q8N682 Q8N682 DRAM1 PTHR21324:SF11 FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED DNA DAMAGE-REGULATED AUTOPHAGY MODULATOR PROTEIN 1 biological regulation#GO:0065007;regulation of catabolic process#GO:0009894;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of autophagy#GO:0010506;regulation of metabolic process#GO:0019222 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;lytic vacuole#GO:0000323;lysosome#GO:0005764;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;vacuole#GO:0005773;cellular anatomical structure#GO:0110165;organelle#GO:0043226 scaffold/adaptor protein#PC00226 HUMAN|HGNC=17830|UniProtKB=Q5VW38 Q5VW38 GPR107 PTHR21229:SF12 LUNG SEVEN TRANSMEMBRANE RECEPTOR PROTEIN GPR107 protein binding#GO:0005515;clathrin binding#GO:0030276;binding#GO:0005488 vesicle-mediated transport#GO:0016192;endocytosis#GO:0006897;clathrin-dependent endocytosis#GO:0072583;cellular process#GO:0009987;localization#GO:0051179;establishment of localization#GO:0051234;import into cell#GO:0098657;receptor-mediated endocytosis#GO:0006898;transport#GO:0006810 Golgi apparatus#GO:0005794;clathrin-coated vesicle#GO:0030136;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;coated vesicle#GO:0030135;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular vesicle#GO:0097708;membrane#GO:0016020;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=1725|UniProtKB=P30304 P30304 CDC25A PTHR10828:SF46 M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25 M-PHASE INDUCER PHOSPHATASE 1 hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725;phosphoprotein phosphatase activity#GO:0004721;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791 mitotic cell cycle process#GO:1903047;positive regulation of mitotic cell cycle#GO:0045931;biological regulation#GO:0065007;regulation of cell cycle process#GO:0010564;positive regulation of cell cycle#GO:0045787;regulation of reproductive process#GO:2000241;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cell cycle G2/M phase transition#GO:0044839;regulation of mitotic cell cycle#GO:0007346;cellular process#GO:0009987;regulation of cell cycle G2/M phase transition#GO:1902749;regulation of mitotic cell cycle phase transition#GO:1901990;regulation of G2/M transition of mitotic cell cycle#GO:0010389;mitotic cell cycle phase transition#GO:0044772;regulation of cell cycle#GO:0051726;mitotic cell cycle#GO:0000278;cell cycle phase transition#GO:0044770;G2/M transition of mitotic cell cycle#GO:0000086;regulation of cellular process#GO:0050794;positive regulation of cell cycle process#GO:0090068;regulation of biological process#GO:0050789;regulation of meiotic cell cycle#GO:0051445;cell cycle process#GO:0022402;cell cycle#GO:0007049;regulation of cell cycle phase transition#GO:1901987 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 protein modifying enzyme#PC00260;protein phosphatase#PC00195 p53 pathway#P00059>Cdc25C#P04624 HUMAN|HGNC=26467|UniProtKB=Q8N4Q1 Q8N4Q1 CHCHD4 PTHR21622:SF6 COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4 MITOCHONDRIAL INTERMEMBRANE SPACE IMPORT AND ASSEMBLY PROTEIN 40 protein-disulfide reductase activity#GO:0015035;oxidoreductase activity#GO:0016491;catalytic activity, acting on a protein#GO:0140096;disulfide oxidoreductase activity#GO:0015036;catalytic activity#GO:0003824;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667 protein maturation#GO:0051604;gene expression#GO:0010467;mitochondrial protein import pathway#GO:7770058;biosynthetic process#GO:0009058;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;establishment of localization#GO:0051234;metabolic process#GO:0008152;intracellular transport#GO:0046907;transport#GO:0006810;mitochondrial transport#GO:0006839;primary metabolic process#GO:0044238;localization#GO:0051179;protein metabolic process#GO:0019538;cellular localization#GO:0051641 mitochondrial intermembrane space#GO:0005758;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;organelle envelope#GO:0031967;mitochondrial envelope#GO:0005740;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=12579|UniProtKB=O00526 O00526 UPK2 PTHR17573:SF0 UROPLAKIN II UROPLAKIN-2 anatomical structure development#GO:0048856;cellular developmental process#GO:0048869;developmental process#GO:0032502;animal gross anatomical part developmental process#GO:0160108;cell differentiation#GO:0030154;epithelium development#GO:0060429;epithelial cell differentiation#GO:0030855;tissue development#GO:0009888;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;cell periphery#GO:0071944;apical part of cell#GO:0045177;membrane#GO:0016020;apical plasma membrane#GO:0016324 HUMAN|HGNC=19173|UniProtKB=Q8TAZ6 Q8TAZ6 CMTM2 PTHR22776:SF15 MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN CKLF-LIKE MARVEL TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 2 signaling#GO:0023052;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;anatomical structure development#GO:0048856;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;cellular component assembly involved in morphogenesis#GO:0010927;multicellular organismal process#GO:0032501;cellular component assembly#GO:0022607;nervous system development#GO:0007399;biological regulation#GO:0065007;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;anatomical structure formation involved in morphogenesis#GO:0048646;myelination#GO:0042552;cellular anatomical entity morphogenesis#GO:0032989;developmental process#GO:0032502 cell periphery#GO:0071944;apical plasma membrane#GO:0016324;membrane#GO:0016020;myelin sheath#GO:0043209;plasma membrane#GO:0005886;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;apical part of cell#GO:0045177 scaffold/adaptor protein#PC00226 HUMAN|HGNC=32270|UniProtKB=A8MWA6 A8MWA6 FAM90A22 PTHR16035:SF14 PROTEIN FAM90A1 PROTEIN FAM90A10-RELATED HUMAN|HGNC=11999|UniProtKB=Q12888 Q12888 TP53BP1 PTHR15321:SF3 TUMOR SUPPRESSOR P53-BINDING PROTEIN 1 TP53-BINDING PROTEIN 1 chromatin-protein adaptor activity#GO:0140463;histone reader activity#GO:0140566;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 negative regulation of cell cycle#GO:0045786;double-strand break repair#GO:0006302;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;positive regulation of transcription by RNA polymerase II#GO:0045944;cell cycle checkpoint signaling#GO:0000075;positive regulation of macromolecule metabolic process#GO:0010604;regulation of cell cycle process#GO:0010564;response to stress#GO:0006950;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;cellular response to stress#GO:0033554;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;regulation of cell cycle#GO:0051726;signaling#GO:0023052;negative regulation of cell cycle phase transition#GO:1901988;negative regulation of biological process#GO:0048519;signal transduction in response to DNA damage#GO:0042770;regulation of biological process#GO:0050789;double-strand break repair via nonhomologous end joining#GO:0006303;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;DNA repair#GO:0006281;negative regulation of cell cycle process#GO:0010948;DNA damage response#GO:0006974;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;DNA damage checkpoint signaling#GO:0000077;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;DNA integrity checkpoint signaling#GO:0031570;positive regulation of cellular process#GO:0048522;regulation of DNA-templated transcription#GO:0006355;cell communication#GO:0007154;positive regulation of biosynthetic process#GO:0009891;intracellular signal transduction#GO:0035556;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of cell cycle phase transition#GO:1901987;cellular response to stimulus#GO:0051716 chromosome#GO:0005694;site of double-strand break#GO:0035861;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;site of DNA damage#GO:0090734;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 DNA metabolism protein#PC00009 HUMAN|HGNC=20898|UniProtKB=Q6PCE3 Q6PCE3 PGM2L1 PTHR45745:SF2 PHOSPHOMANNOMUTASE 45A GLUCOSE 1,6-BISPHOSPHATE SYNTHASE intramolecular phosphotransferase activity#GO:0016868;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;isomerase activity#GO:0016853;intramolecular transferase activity#GO:0016866;phosphotransferase activity, alcohol group as acceptor#GO:0016773 metabolic process#GO:0008152;purine-containing compound biosynthetic process#GO:0072522;nucleobase-containing compound biosynthetic process#GO:0034654;purine nucleoside metabolic process#GO:0042278;small molecule biosynthetic process#GO:0044283;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;purine-containing compound metabolic process#GO:0072521;cellular process#GO:0009987;small molecule metabolic process#GO:0044281;nucleoside metabolic process#GO:0009116;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058 isomerase#PC00135;metabolite interconversion enzyme#PC00262;mutase#PC00160 HUMAN|HGNC=16203|UniProtKB=Q96DR5 Q96DR5 BPIFA2 PTHR47145:SF1 BPI FOLD-CONTAINING FAMILY A MEMBER 2 BPI FOLD-CONTAINING FAMILY A MEMBER 2 lipid binding#GO:0008289;carbohydrate derivative binding#GO:0097367;binding#GO:0005488;lipopolysaccharide binding#GO:0001530 intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;vesicle#GO:0031982;secretory vesicle#GO:0099503;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=6514|UniProtKB=O95835 O95835 LATS1 PTHR24356:SF138 SERINE/THREONINE-PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE LATS1 protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096 regulation of programmed cell death#GO:0043067;cell cycle#GO:0007049;regulation of biological process#GO:0050789;regulation of growth#GO:0040008;cell cycle process#GO:0022402;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;mitotic cell cycle#GO:0000278;cell cycle phase transition#GO:0044770;regulation of cellular process#GO:0050794;positive regulation of programmed cell death#GO:0043068;regulation of developmental process#GO:0050793;signaling#GO:0023052;mitotic cell cycle phase transition#GO:0044772;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cell cycle G1/S phase transition#GO:0044843;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;hippo signaling#GO:0035329;regulation of multicellular organismal process#GO:0051239;G1/S transition of mitotic cell cycle#GO:0000082;regulation of apoptotic process#GO:0042981;positive regulation of apoptotic process#GO:0043065;mitotic cell cycle process#GO:1903047 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;spindle#GO:0005819;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;microtubule cytoskeleton#GO:0015630;spindle pole#GO:0000922 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=32565|UniProtKB=A6ND01 A6ND01 IZUMO1R PTHR10517:SF10 FOLATE RECEPTOR SPERM-EGG FUSION PROTEIN JUNO signaling receptor activity#GO:0038023;cargo receptor activity#GO:0038024;molecular transducer activity#GO:0060089 establishment of localization#GO:0051234;cell-cell recognition#GO:0009988;sperm-egg recognition#GO:0035036;organic acid transport#GO:0015849;carboxylic acid transport#GO:0046942;transport#GO:0006810;dicarboxylic acid transport#GO:0006835;nitrogen compound transport#GO:0071705;single fertilization#GO:0007338;cellular process#GO:0009987;fusion of sperm to egg plasma membrane involved in single fertilization#GO:0007342;localization#GO:0051179;multicellular organismal reproductive process#GO:0048609;cell recognition#GO:0008037;sexual reproduction#GO:0019953;vitamin transport#GO:0051180;fertilization#GO:0009566;cellular process involved in reproduction in multicellular organism#GO:0022412;reproductive process#GO:0022414 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=26679|UniProtKB=Q5VTT5 Q5VTT5 MYOM3 PTHR13817:SF89 TITIN MYOMESIN-3 structural molecule activity#GO:0005198 membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;muscle cell development#GO:0055001;anatomical structure morphogenesis#GO:0009653;muscle cell differentiation#GO:0042692;myofibril assembly#GO:0030239;actin cytoskeleton organization#GO:0030036;muscle structure development#GO:0061061;cell differentiation#GO:0030154;cell development#GO:0048468;actomyosin structure organization#GO:0031032;cellular component assembly involved in morphogenesis#GO:0010927;animal gross anatomical part developmental process#GO:0160108;organelle assembly#GO:0070925;sarcomere organization#GO:0045214;actin filament-based process#GO:0030029;anatomical structure development#GO:0048856;striated muscle cell development#GO:0055002;supramolecular fiber organization#GO:0097435;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;cellular anatomical entity morphogenesis#GO:0032989;developmental process#GO:0032502;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;striated muscle cell differentiation#GO:0051146;anatomical structure formation involved in morphogenesis#GO:0048646 intracellular organelle#GO:0043229;M band#GO:0031430;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;sarcomere#GO:0030017;membraneless organelle#GO:0043228;myofibril#GO:0030016;contractile muscle fiber#GO:0043292;A band#GO:0031672;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;supramolecular complex#GO:0099080;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081 structural protein#PC00211 HUMAN|HGNC=4531|UniProtKB=Q96P68 Q96P68 OXGR1 PTHR24231:SF15 PURINOCEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR 2-OXOGLUTARATE RECEPTOR 1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=11155|UniProtKB=P08579 P08579 SNRPB2 PTHR10501:SF84 U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B'' snRNA binding#GO:0017069;RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;mRNA splicing, via spliceosome#GO:0000398;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Sm-like protein family complex#GO:0120114;spliceosomal snRNP complex#GO:0097525;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;small nuclear ribonucleoprotein complex#GO:0030532;intracellular membrane-bounded organelle#GO:0043231;U1 snRNP#GO:0005685;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 RNA splicing factor#PC00148;RNA metabolism protein#PC00031;RNA processing factor#PC00147 mRNA splicing#P00058>U2#P01478 HUMAN|HGNC=25280|UniProtKB=Q96NG3 Q96NG3 ODAD4 PTHR23040:SF1 OUTER DYNEIN ARM-DOCKING COMPLEX SUBUNIT 4 OUTER DYNEIN ARM-DOCKING COMPLEX SUBUNIT 4 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=29276|UniProtKB=Q9P2B7 Q9P2B7 CFAP97 PTHR23035:SF1 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 97-RELATED CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 97 HUMAN|HGNC=11215|UniProtKB=O75602 O75602 SPAG6 PTHR23314:SF3 SPERM-ASSOCIATED ANTIGEN 6 ARMADILLO REPEAT-CONTAINING SPERM-ASSOCIATED ANTIGEN 6 cilium movement#GO:0003341;cellular process#GO:0009987;microtubule-based movement#GO:0007018;microtubule-based process#GO:0007017 microtubule cytoskeleton#GO:0015630;ciliary plasm#GO:0097014;sperm flagellum#GO:0036126;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;sperm principal piece#GO:0097228;cellular anatomical structure#GO:0110165;motile cilium#GO:0031514;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cilium#GO:0005929;9+2 motile cilium#GO:0097729;intracellular organelle#GO:0043229;axoneme#GO:0005930;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 microtubule or microtubule-binding cytoskeletal protein#PC00157;cytoskeletal protein#PC00085 HUMAN|HGNC=25179|UniProtKB=Q96CM4 Q96CM4 NXNL1 PTHR47109:SF1 NUCLEOREDOXIN-LIKE PROTEIN 1 NUCLEOREDOXIN-LIKE PROTEIN 1 mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HUMAN|HGNC=19420|UniProtKB=Q8TAV4 Q8TAV4 STOML3 PTHR10264:SF49 BAND 7 PROTEIN-RELATED STOMATIN-LIKE PROTEIN 3 transporter regulator activity#GO:0141108;ion channel regulator activity#GO:0099106;ion channel inhibitor activity#GO:0008200;channel regulator activity#GO:0016247;molecular function inhibitor activity#GO:0140678;molecular function regulator activity#GO:0098772 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 cytoskeletal protein#PC00085 HUMAN|HGNC=27265|UniProtKB=P68543 P68543 UBXN2A PTHR23333:SF16 UBX DOMAIN CONTAINING PROTEIN UBX DOMAIN-CONTAINING PROTEIN 2A binding#GO:0005488;ubiquitin binding#GO:0043130;protein binding#GO:0005515 regulation of cellular response to stress#GO:0080135;spindle localization#GO:0051653;cellular localization#GO:0051641;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;establishment or maintenance of cell polarity#GO:0007163;negative regulation of metabolic process#GO:0009892;establishment of organelle localization#GO:0051656;cell cycle process#GO:0022402;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;establishment of spindle orientation#GO:0051294;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;proteasomal protein catabolic process#GO:0010498;cytoskeleton organization#GO:0007010;regulation of proteasomal protein catabolic process#GO:0061136;negative regulation of protein catabolic process#GO:0042177;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;regulation of protein metabolic process#GO:0051246;establishment of mitotic spindle localization#GO:0040001;organelle organization#GO:0006996;regulation of protein catabolic process#GO:0042176;negative regulation of catabolic process#GO:0009895;protein metabolic process#GO:0019538;microtubule cytoskeleton organization#GO:0000226;localization#GO:0051179;organelle localization#GO:0051640;negative regulation of protein metabolic process#GO:0051248;negative regulation of proteasomal protein catabolic process#GO:1901799;regulation of ERAD pathway#GO:1904292;regulation of cellular process#GO:0050794;mitotic cell cycle#GO:0000278;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of response to endoplasmic reticulum stress#GO:1905897;modification-dependent protein catabolic process#GO:0019941;establishment of cell polarity#GO:0030010;primary metabolic process#GO:0044238;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cell cycle#GO:0007049;ubiquitin-dependent protein catabolic process#GO:0006511;regulation of catabolic process#GO:0009894;mitotic cell cycle process#GO:1903047;establishment of mitotic spindle orientation#GO:0000132;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;regulation of response to stimulus#GO:0048583;regulation of response to stress#GO:0080134;negative regulation of cellular process#GO:0048523;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;biological regulation#GO:0065007;negative regulation of response to stimulus#GO:0048585;negative regulation of macromolecule metabolic process#GO:0010605;establishment of spindle localization#GO:0051293;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;endoplasmic reticulum#GO:0005783;ATPase complex#GO:1904949;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 protein-binding activity modulator#PC00095 HUMAN|HGNC=8607|UniProtKB=O60260 O60260 PRKN PTHR11685:SF448 RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING E3 UBIQUITIN-PROTEIN LIGASE PARKIN catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein binding#GO:0005515;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;binding#GO:0005488;ubiquitin-like protein transferase activity#GO:0019787;enzyme binding#GO:0019899;ubiquitin protein ligase activity#GO:0061630 protein catabolic process#GO:0030163;regulation of signaling#GO:0023051;modification-dependent macromolecule catabolic process#GO:0043632;protein metabolic process#GO:0019538;process utilizing autophagic mechanism#GO:0061919;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;metabolic process#GO:0008152;autophagy of mitochondrion#GO:0000422;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;mitophagy#GO:0000423;ubiquitin-dependent protein catabolic process#GO:0006511;autophagy#GO:0006914;cellular process#GO:0009987;regulation of trans-synaptic signaling#GO:0099177;biological regulation#GO:0065007;macroautophagy#GO:0016236 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;endoplasmic reticulum#GO:0005783;Golgi apparatus#GO:0005794;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytosol#GO:0005829 ubiquitin-protein ligase#PC00234 Parkinson disease#P00049>Parkin#P01216 HUMAN|HGNC=24785|UniProtKB=A6XGL0 A6XGL0 YJEFN3 PTHR13232:SF12 NAD(P)H-HYDRATE EPIMERASE YJEF N-TERMINAL DOMAIN-CONTAINING PROTEIN 3 isomerase activity#GO:0016853;racemase and epimerase activity#GO:0016854;catalytic activity#GO:0003824 mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 metabolite interconversion enzyme#PC00262;epimerase/racemase#PC00096 HUMAN|HGNC=11075|UniProtKB=O14745 O14745 NHERF1 PTHR14191:SF7 PDZ DOMAIN CONTAINING PROTEIN NA(+)_H(+) EXCHANGE REGULATORY COFACTOR NHE-RF1 signaling receptor binding#GO:0005102;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;protein-membrane adaptor activity#GO:0043495;protein binding#GO:0005515 protein localization to membrane#GO:0072657;macromolecule localization#GO:0033036;protein localization to plasma membrane#GO:0072659;cellular process#GO:0009987;localization#GO:0051179;cellular localization#GO:0051641;intracellular protein localization#GO:0008104;protein localization to cell periphery#GO:1990778;localization within membrane#GO:0051668 cell periphery#GO:0071944;apical part of cell#GO:0045177;membrane#GO:0016020;apical plasma membrane#GO:0016324;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590 scaffold/adaptor protein#PC00226 HUMAN|HGNC=680|UniProtKB=Q99819 Q99819 ARHGDIG PTHR10980:SF8 RHO GDP-DISSOCIATION INHIBITOR RHO GDP-DISSOCIATION INHIBITOR 3 GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;intracellular signaling cassette#GO:0141124;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;intracellular signal transduction#GO:0035556;Rho protein signal transduction#GO:0007266;cell communication#GO:0007154 cytosol#GO:0005829;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HUMAN|HGNC=15214|UniProtKB=Q8NH55 Q8NH55 OR52E5 PTHR26450:SF23 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 52E5 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=28033|UniProtKB=Q6PII3 Q6PII3 CCDC174 PTHR15885:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 174 COILED-COIL DOMAIN-CONTAINING PROTEIN 174 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=19410|UniProtKB=Q86VH5 Q86VH5 LRRTM3 PTHR24373:SF296 SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN LEUCINE-RICH REPEAT TRANSMEMBRANE NEURONAL PROTEIN 3 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=7891|UniProtKB=Q9NPH5 Q9NPH5 NOX4 PTHR11972:SF206 NADPH OXIDASE NADPH OXIDASE 4 catalytic activity#GO:0003824;oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor#GO:0050664;oxidoreductase activity, acting on NAD(P)H#GO:0016651;oxidoreductase activity#GO:0016491 cellular process#GO:0009987;metabolic process#GO:0008152;response to stress#GO:0006950;reactive oxygen species metabolic process#GO:0072593;defense response#GO:0006952;superoxide metabolic process#GO:0006801;response to stimulus#GO:0050896 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane protein complex#GO:0098796;oxidoreductase complex#GO:1990204;membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;catalytic complex#GO:1902494 oxidase#PC00175;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=8847|UniProtKB=P56645 P56645 PER3 PTHR11269:SF13 PERIOD CIRCADIAN PROTEIN PERIOD CIRCADIAN PROTEIN HOMOLOG 3 binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;protein binding#GO:0005515;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;transcription factor binding#GO:0008134;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of gene expression#GO:0010468;response to external stimulus#GO:0009605;regulation of biosynthetic process#GO:0009889;photoperiodism#GO:0009648;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;response to radiation#GO:0009314;negative regulation of macromolecule metabolic process#GO:0010605;regulation of circadian rhythm#GO:0042752;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of DNA-templated transcription#GO:0006355;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;response to light stimulus#GO:0009416;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of macromolecule biosynthetic process#GO:0010558;circadian rhythm#GO:0007623;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;rhythmic process#GO:0048511;negative regulation of metabolic process#GO:0009892;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;circadian regulation of gene expression#GO:0032922;response to abiotic stimulus#GO:0009628;negative regulation of biological process#GO:0048519 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 transcription cofactor#PC00217 Circadian clock system#P00015>per#G01499;Circadian clock system#P00015>per#G01503;Circadian clock system#P00015>Per#P00504 HUMAN|HGNC=10299|UniProtKB=P62906 P62906 RPL10A PTHR23105:SF186 RIBOSOMAL PROTEIN L7AE FAMILY MEMBER LARGE RIBOSOMAL SUBUNIT PROTEIN UL1 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;ribosome#GO:0005840;cytosol#GO:0005829;cytosolic large ribosomal subunit#GO:0022625;cytosolic ribosome#GO:0022626;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 translational protein#PC00263;ribosomal protein#PC00202 HUMAN|HGNC=21899|UniProtKB=Q674R7 Q674R7 ATG9B PTHR13038:SF14 APG9 AUTOPHAGY 9 AUTOPHAGY-RELATED PROTEIN 9B molecular carrier activity#GO:0140104;lipid carrier activity#GO:0005319;phospholipid scramblase activity#GO:0017128;transporter activity#GO:0005215;intramembrane lipid carrier activity#GO:0140303 cellular component organization#GO:0016043;piecemeal microautophagy of the nucleus#GO:0034727;catabolic process#GO:0009056;organelle assembly#GO:0070925;process utilizing autophagic mechanism#GO:0061919;vacuole organization#GO:0007033;localization#GO:0051179;autophagosome organization#GO:1905037;cellular process#GO:0009987;autophagy#GO:0006914;reticulophagy#GO:0061709;organelle organization#GO:0006996;macromolecule localization#GO:0033036;cellular component biogenesis#GO:0044085;macroautophagy#GO:0016236;cellular component assembly#GO:0022607;autophagy of mitochondrion#GO:0000422;metabolic process#GO:0008152;autophagosome assembly#GO:0000045;intracellular protein localization#GO:0008104;mitophagy#GO:0000423;cellular component organization or biogenesis#GO:0071840 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;vacuole#GO:0005773;autophagosome#GO:0005776;intracellular organelle#GO:0043229;phagophore assembly site#GO:0000407;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=11602|UniProtKB=O15119 O15119 TBX3 PTHR11267:SF91 T-BOX PROTEIN-RELATED T-BOX TRANSCRIPTION FACTOR TBX3 RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of DNA-templated transcription#GO:0006355;cell fate commitment#GO:0045165;regulation of RNA metabolic process#GO:0051252;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;developmental process#GO:0032502;cell fate specification#GO:0001708;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;cellular process#GO:0009987 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;nucleus#GO:0005634;chromatin#GO:0000785;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 Rel homology transcription factor#PC00252;immunoglobulin fold transcription factor#PC00251 HUMAN|HGNC=25613|UniProtKB=Q69YN2 Q69YN2 CWF19L1 PTHR12072:SF4 CWF19, CELL CYCLE CONTROL PROTEIN CWF19-LIKE PROTEIN 1 enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;post-mRNA release spliceosomal complex#GO:0071014;spliceosomal complex#GO:0005681;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229 HUMAN|HGNC=6973|UniProtKB=Q00987 Q00987 MDM2 PTHR46858:SF13 OS05G0521000 PROTEIN E3 UBIQUITIN-PROTEIN LIGASE MDM2 ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of cell communication#GO:0010646;primary metabolic process#GO:0044238;regulation of intrinsic apoptotic signaling pathway#GO:2001242;modification-dependent protein catabolic process#GO:0019941;protein metabolic process#GO:0019538;regulation of apoptotic signaling pathway#GO:2001233;negative regulation of apoptotic signaling pathway#GO:2001234;negative regulation of response to stimulus#GO:0048585;negative regulation of apoptotic process#GO:0043066;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of mitotic cell cycle#GO:0007346;positive regulation of cellular process#GO:0048522;macromolecule metabolic process#GO:0043170;positive regulation of mitotic cell cycle#GO:0045931;ubiquitin-dependent protein catabolic process#GO:0006511;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of cell cycle#GO:0051726;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;negative regulation of signal transduction#GO:0009968;positive regulation of cell cycle#GO:0045787;cellular process#GO:0009987;negative regulation of programmed cell death#GO:0043069;positive regulation of biological process#GO:0048518;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;negative regulation of intrinsic apoptotic signaling pathway#GO:2001243;regulation of apoptotic process#GO:0042981 intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 p53 pathway feedback loops 2#P04398>MDM-2#G04709;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>Mdm2#G04674;P53 pathway feedback loops 1#P04392>Mdm2#P04536;P53 pathway feedback loops 1#P04392>MDM-2#G04682;p53 pathway#P00059>Mdm2#P01483;Ubiquitin proteasome pathway#P00060>E3#P01490;p53 pathway#P00059>MDM-2#G01563;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>Mdm2#P04496;p53 pathway feedback loops 2#P04398>Mdm2#P04663 HUMAN|HGNC=37274|UniProtKB=Q5JSQ8 Q5JSQ8 KHDC1L PTHR31368:SF5 DEVELOPMENT PLURPOTENCY-ASSOCIATED PROTEIN 1/5 FAMILY MEMBER KHDC1-LIKE PROTEIN RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=12774|UniProtKB=P04628 P04628 WNT1 PTHR12027:SF91 WNT RELATED PROTO-ONCOGENE WNT-1 cytokine activity#GO:0005125;binding#GO:0005488;signaling receptor binding#GO:0005102;molecular function activator activity#GO:0140677;protein binding#GO:0005515;frizzled binding#GO:0005109;G protein-coupled receptor binding#GO:0001664;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772 system development#GO:0048731;cell fate commitment#GO:0045165;cell communication#GO:0007154;canonical Wnt signaling pathway#GO:0060070;anatomical structure development#GO:0048856;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;signaling#GO:0023052;cell differentiation#GO:0030154;response to stimulus#GO:0050896;Wnt signaling pathway#GO:0016055;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;neurogenesis#GO:0022008;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;neuron differentiation#GO:0030182;developmental process#GO:0032502;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;signal transduction#GO:0007165;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 Angiogenesis#P00005>Wnt#P00206;Cadherin signaling pathway#P00012>Wnt#P00474;Alzheimer disease-presenilin pathway#P00004>Wnt#P00142;Wnt signaling pathway#P00057>Wnt#P01444 HUMAN|HGNC=22946|UniProtKB=Q96FL9 Q96FL9 GALNT14 PTHR11675:SF8 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 14 catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758;catalytic activity, acting on a protein#GO:0140096;UDP-glycosyltransferase activity#GO:0008194;acetylgalactosaminyltransferase activity#GO:0008376;glycosyltransferase activity#GO:0016757;polypeptide N-acetylgalactosaminyltransferase activity#GO:0004653 metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;protein O-linked glycosylation#GO:0006493;macromolecule biosynthetic process#GO:0009059;biosynthetic process#GO:0009058 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 glycosyltransferase#PC00111;transferase#PC00220 HUMAN|HGNC=8862|UniProtKB=P10720 P10720 PF4V1 PTHR12015:SF189 SMALL INDUCIBLE CYTOKINE A PLATELET FACTOR 4 VARIANT receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;chemokine activity#GO:0008009;G protein-coupled receptor binding#GO:0001664;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;cytokine activity#GO:0005125;binding#GO:0005488;signaling receptor binding#GO:0005102;cytokine receptor binding#GO:0005126;protein binding#GO:0005515;chemokine receptor binding#GO:0042379;molecular function activator activity#GO:0140677 neutrophil chemotaxis#GO:0030593;antimicrobial humoral response#GO:0019730;humoral immune response#GO:0006959;response to lipopolysaccharide#GO:0032496;defense response to symbiont#GO:0140546;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987;response to biotic stimulus#GO:0009607;cellular response to lipopolysaccharide#GO:0071222;response to stress#GO:0006950;response to chemical#GO:0042221;taxis#GO:0042330;neutrophil migration#GO:1990266;response to lipid#GO:0033993;granulocyte migration#GO:0097530;defense response to other organism#GO:0098542;cellular response to lipid#GO:0071396;response to oxygen-containing compound#GO:1901700;immune system process#GO:0002376;cellular response to chemical stimulus#GO:0070887;response to molecule of bacterial origin#GO:0002237;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;granulocyte chemotaxis#GO:0071621;leukocyte migration#GO:0050900;myeloid leukocyte migration#GO:0097529;response to external stimulus#GO:0009605;defense response#GO:0006952;leukocyte chemotaxis#GO:0030595;cellular response to molecule of bacterial origin#GO:0071219;immune response#GO:0006955;response to other organism#GO:0051707;cell migration#GO:0016477;chemotaxis#GO:0006935;inflammatory response#GO:0006954;response to bacterium#GO:0009617;cell chemotaxis#GO:0060326;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;cellular response to stimulus#GO:0051716;cellular response to biotic stimulus#GO:0071216;response to external biotic stimulus#GO:0043207;locomotion#GO:0040011;cell motility#GO:0048870 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 cytokine#PC00083 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CHK#P00856 HUMAN|HGNC=7705|UniProtKB=O43677 O43677 NDUFC1 PTHR17097:SF0 NADH-UBIQUINONE OXIDOREDUCTASE KFYI SUBUNIT NADH DEHYDROGENASE [UBIQUINONE] 1 SUBUNIT C1, MITOCHONDRIAL respiratory chain complex#GO:0098803;membrane protein complex#GO:0098796;membrane#GO:0016020;oxidoreductase complex#GO:1990204;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;respiratory chain complex I#GO:0045271;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351 oxidoreductase#PC00176 HUMAN|HGNC=18988|UniProtKB=O94900 O94900 TOX PTHR45781:SF4 AGAP000281-PA THYMOCYTE SELECTION-ASSOCIATED HIGH MOBILITY GROUP BOX PROTEIN TOX DNA binding#GO:0003677;chromatin DNA binding#GO:0031490;chromatin binding#GO:0003682;binding#GO:0005488;nucleic acid binding#GO:0003676 cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;developmental process#GO:0032502;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;hemopoiesis#GO:0030097;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;cell development#GO:0048468;leukocyte differentiation#GO:0002521;regulation of biological process#GO:0050789 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 DNA-binding transcription factor#PC00218;HMG box transcription factor#PC00024 HUMAN|HGNC=23504|UniProtKB=Q86XD8 Q86XD8 ZFAND4 PTHR46728:SF1 AN1-TYPE ZINC FINGER PROTEIN 4 AN1-TYPE ZINC FINGER PROTEIN 4 HUMAN|HGNC=11732|UniProtKB=Q96S53 Q96S53 TESK2 PTHR46485:SF6 LIM DOMAIN KINASE 1 DUAL SPECIFICITY TESTIS-SPECIFIC PROTEIN KINASE 2 protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096 cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;actin filament-based process#GO:0030029;actin cytoskeleton organization#GO:0030036;cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=14853|UniProtKB=Q8NH53 Q8NH53 OR52N1 PTHR26450:SF145 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 52N1 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=7578|UniProtKB=P13535 P13535 MYH8 PTHR45615:SF35 MYOSIN HEAVY CHAIN, NON-MUSCLE MYOSIN-8 cytoskeletal motor activity#GO:0003774;isomerase activity#GO:0016853;microfilament motor activity#GO:0000146;catalytic activity#GO:0003824;cytoskeletal protein binding#GO:0008092;macromolecular conformation isomerase activity#GO:0120543;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;polypeptide conformation or assembly isomerase activity#GO:0120544;binding#GO:0005488;ATP-dependent activity#GO:0140657;actin filament binding#GO:0051015;actin binding#GO:0003779 system process#GO:0003008;multicellular organismal process#GO:0032501;muscle system process#GO:0003012;muscle contraction#GO:0006936 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;actin cytoskeleton#GO:0015629;myosin complex#GO:0016459;supramolecular complex#GO:0099080;organelle#GO:0043226;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737 actin or actin-binding cytoskeletal protein#PC00041 Cytoskeletal regulation by Rho GTPase#P00016>Myosin#P00522;Wnt signaling pathway#P00057>NFAT Target Genes#G01559;Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Myosin#P00867 HUMAN|HGNC=15899|UniProtKB=Q5TEU4 Q5TEU4 NDUFAF5 PTHR13090:SF1 ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;NADH dehydrogenase complex assembly#GO:0010257;mitochondrial respiratory chain complex I assembly#GO:0032981;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;cellular component assembly#GO:0022607;mitochondrial respiratory chain complex assembly#GO:0033108;mitochondrion organization#GO:0007005 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739 HUMAN|HGNC=13175|UniProtKB=A8MXY4 A8MXY4 ZNF99 PTHR24376:SF71 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 99 gene-specific transcriptional regulator#PC00264;zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=24840|UniProtKB=Q9UBC7 Q9UBC7 GALP PTHR20950:SF1 GALANIN-RELATED PEPTIDE GALANIN-LIKE PEPTIDE response to nutrient levels#GO:0031667;response to starvation#GO:0042594;response to stress#GO:0006950;response to stimulus#GO:0050896 HUMAN|HGNC=333|UniProtKB=P01019 P01019 AGT PTHR11461:SF13 SERINE PROTEASE INHIBITOR, SERPIN ANGIOTENSINOGEN enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;serine-type endopeptidase inhibitor activity#GO:0004867;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;peptidase regulator activity#GO:0061134;endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772;enzyme inhibitor activity#GO:0004857 regulation of apoptotic process#GO:0042981;biological regulation#GO:0065007;response to peptide hormone#GO:0043434;response to chemical#GO:0042221;cellular response to nitrogen compound#GO:1901699;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987;response to hormone#GO:0009725;response to nitrogen compound#GO:1901698;cell communication#GO:0007154;response to oxygen-containing compound#GO:1901700;G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887;signaling#GO:0023052;cellular response to peptide hormone stimulus#GO:0071375;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;cellular response to hormone stimulus#GO:0032870;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to endogenous stimulus#GO:0009719;regulation of programmed cell death#GO:0043067 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease inhibitor#PC00191 Angiotensin II-stimulated signaling through G proteins and beta-arrestin#P05911>AngII#P05935 HUMAN|HGNC=33769|UniProtKB=P0C671 P0C671 BNIP5 PTHR22435:SF0 CHROMOSOME 6 OPEN READING FRAME 222 PROTEIN BNIP5 HUMAN|HGNC=3058|UniProtKB=O60941 O60941 DTNB PTHR12268:SF22 E3 UBIQUITIN-PROTEIN LIGASE KCMF1 DYSTROBREVIN BETA multicellular organism development#GO:0007275;anatomical structure development#GO:0048856;cellular developmental process#GO:0048869;system development#GO:0048731;neurogenesis#GO:0022008;animal gross anatomical part developmental process#GO:0160108;neuron differentiation#GO:0030182;generation of neurons#GO:0048699;developmental process#GO:0032502;cell differentiation#GO:0030154;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;synapse#GO:0045202;cell junction#GO:0030054;plasma membrane#GO:0005886 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=34361|UniProtKB=A6NNP5 A6NNP5 CCDC169 PTHR28671:SF3 COILED-COIL DOMAIN-CONTAINING PROTEIN 169 COILED-COIL DOMAIN-CONTAINING PROTEIN 169 HUMAN|HGNC=26688|UniProtKB=Q8IYX3 Q8IYX3 CCDC116 PTHR36861:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 116 COILED-COIL DOMAIN-CONTAINING PROTEIN 116 HUMAN|HGNC=29024|UniProtKB=O15084 O15084 ANKRD28 PTHR24123:SF75 ANKYRIN REPEAT-CONTAINING SERINE_THREONINE-PROTEIN PHOSPHATASE 6 REGULATORY ANKYRIN REPEAT SUBUNIT A enzyme regulator activity#GO:0030234;phosphatase regulator activity#GO:0019208;molecular function regulator activity#GO:0098772;protein phosphatase regulator activity#GO:0019888 regulation of cell-matrix adhesion#GO:0001952;regulation of cell junction assembly#GO:1901888;positive regulation of cellular component organization#GO:0051130;regulation of cellular component biogenesis#GO:0044087;regulation of cell-substrate adhesion#GO:0010810;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;positive regulation of cellular component biogenesis#GO:0044089;regulation of cell adhesion#GO:0030155;regulation of cellular component organization#GO:0051128;positive regulation of cell-substrate adhesion#GO:0010811;positive regulation of cell adhesion#GO:0045785;positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789;positive regulation of cellular process#GO:0048522 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829;protein serine/threonine phosphatase complex#GO:0008287;catalytic complex#GO:1902494 scaffold/adaptor protein#PC00226 HUMAN|HGNC=13847|UniProtKB=Q5JNZ3 Q5JNZ3 ZNF311 PTHR24377:SF273 IP01015P-RELATED ZINC FINGER PROTEIN 311 double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=15461|UniProtKB=P55145 P55145 MANF PTHR12990:SF10 ARMET-LIKE PROTEIN MESENCEPHALIC ASTROCYTE-DERIVED NEUROTROPHIC FACTOR signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;receptor ligand activity#GO:0048018;growth factor activity#GO:0008083;signaling receptor regulator activity#GO:0030545 system development#GO:0048731;neuron development#GO:0048666;anatomical structure development#GO:0048856;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cellular component organization#GO:0016043;neurogenesis#GO:0022008;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;neuron differentiation#GO:0030182;developmental process#GO:0032502;plasma membrane bounded cell projection organization#GO:0120036;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;cellular process#GO:0009987;neuron projection development#GO:0031175 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=6063|UniProtKB=Q9H160 Q9H160 ING2 PTHR10333:SF37 INHIBITOR OF GROWTH PROTEIN INHIBITOR OF GROWTH PROTEIN 2 chromatin-protein adaptor activity#GO:0140463;histone reader activity#GO:0140566;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;histone H3 reader activity#GO:0140006 cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;chromatin organization#GO:0006325;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;Sin3-type complex#GO:0070822;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;chromosome#GO:0005694;organelle lumen#GO:0043233;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;chromatin#GO:0000785;histone deacetylase complex#GO:0000118;membrane-enclosed lumen#GO:0031974 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=13531|UniProtKB=Q9Y2Q0 Q9Y2Q0 ATP8A1 PTHR24092:SF221 PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE PHOSPHOLIPID-TRANSPORTING ATPASE IA ATPase-coupled intramembrane lipid carrier activity#GO:0140326;transporter activity#GO:0005215;ATP-dependent activity#GO:0140657;lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104;intramembrane lipid carrier activity#GO:0140303 regulation of biological quality#GO:0065008;localization#GO:0051179;lipid localization#GO:0010876;lipid translocation#GO:0034204;organophosphate ester transport#GO:0015748;cellular component organization#GO:0016043;regulation of membrane lipid distribution#GO:0097035;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;transport#GO:0006810;phospholipid translocation#GO:0045332;phospholipid transport#GO:0015914;membrane organization#GO:0061024;biological regulation#GO:0065007;lipid transport#GO:0006869;cellular process#GO:0009987;macromolecule localization#GO:0033036 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 primary active transporter#PC00068;transporter#PC00227 HUMAN|HGNC=9984|UniProtKB=P48380 P48380 RFX3 PTHR12619:SF20 RFX TRANSCRIPTION FACTOR FAMILY TRANSCRIPTION FACTOR RFX3 cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 winged helix/forkhead transcription factor#PC00246 HUMAN|HGNC=2446|UniProtKB=P07498 P07498 CSN3 PTHR11470:SF2 KAPPA CASEIN KAPPA-CASEIN regulation of body fluid levels#GO:0050878;biological regulation#GO:0065007;regulation of protein stability#GO:0031647;establishment of localization#GO:0051234;animal organ development#GO:0048513;secretion#GO:0046903;anatomical structure development#GO:0048856;localization#GO:0051179;regulation of biological quality#GO:0065008;protein stabilization#GO:0050821;animal gross anatomical part developmental process#GO:0160108;transport#GO:0006810;developmental process#GO:0032502 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 storage protein#PC00210 HUMAN|HGNC=12831|UniProtKB=Q13426 Q13426 XRCC4 PTHR28559:SF2 DNA REPAIR PROTEIN XRCC4 DNA REPAIR PROTEIN XRCC4 anatomical structure development#GO:0048856;system development#GO:0048731;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;somatic diversification of immune receptors#GO:0002200;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;double-strand break repair via nonhomologous end joining#GO:0006303;DNA repair#GO:0006281;DNA damage response#GO:0006974;developmental process#GO:0032502;multicellular organismal process#GO:0032501;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;somatic cell DNA recombination#GO:0016444;response to radiation#GO:0009314;macromolecule biosynthetic process#GO:0009059;immune system development#GO:0002520;immune system process#GO:0002376;animal gross anatomical part developmental process#GO:0160108;somatic diversification of immune receptors via germline recombination within a single locus#GO:0002562;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;production of molecular mediator of immune response#GO:0002440;response to abiotic stimulus#GO:0009628;response to ionizing radiation#GO:0010212;V(D)J recombination#GO:0033151;multicellular organism development#GO:0007275;double-strand break repair#GO:0006302;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;DNA recombination#GO:0006310;gene expression#GO:0010467;response to stress#GO:0006950;somatic recombination of immunoglobulin gene segments#GO:0016447;cellular process#GO:0009987 nucleus#GO:0005634;DNA repair complex#GO:1990391;nonhomologous end joining complex#GO:0070419;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 DNA metabolism protein#PC00009 HUMAN|HGNC=2919|UniProtKB=P56179 P56179 DLX6 PTHR24327:SF26 HOMEOBOX PROTEIN HOMEOBOX PROTEIN DLX-6 RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 developmental process#GO:0032502;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;multicellular organism development#GO:0007275;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;embryo development#GO:0009790;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;animal gross anatomical part developmental process#GO:0160108;chordate embryonic development#GO:0043009;embryo development ending in birth or egg hatching#GO:0009792;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;skeletal system development#GO:0001501;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154 gene-specific transcriptional regulator#PC00264;helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=9579|UniProtKB=O60542 O60542 PSPN PTHR12173:SF8 GDNF SUBFAMILY OF TGF-BETA FAMILY PERSEPHIN molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;signaling receptor regulator activity#GO:0030545;growth factor activity#GO:0008083;receptor ligand activity#GO:0048018 cellular component organization#GO:0016043;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;response to stimulus#GO:0050896;cell projection organization#GO:0030030;cell development#GO:0048468;signaling#GO:0023052;animal gross anatomical part developmental process#GO:0160108;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;generation of neurons#GO:0048699;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;neuron development#GO:0048666;system development#GO:0048731;neuron projection development#GO:0031175;cellular process#GO:0009987;signal transduction#GO:0007165;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;cell surface receptor signaling pathway#GO:0007166;neuron differentiation#GO:0030182;developmental process#GO:0032502;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;neurogenesis#GO:0022008 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207;growth factor#PC00112;neurotrophic factor#PC00163 HUMAN|HGNC=568|UniProtKB=O14617 O14617 AP3D1 PTHR22781:SF14 DELTA ADAPTIN-RELATED AP-3 COMPLEX SUBUNIT DELTA-1 Golgi to vacuole transport#GO:0006896;localization#GO:0051179;anterograde axonal transport#GO:0008089;organelle localization#GO:0051640;axonal transport#GO:0098930;endosome to lysosome transport#GO:0008333;protein localization to vacuole#GO:0072665;microtubule-based movement#GO:0007018;protein localization to organelle#GO:0033365;transport along microtubule#GO:0010970;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;vesicle budding from membrane#GO:0006900;anterograde synaptic vesicle transport#GO:0048490;intracellular protein localization#GO:0008104;vesicle cytoskeletal trafficking#GO:0099518;intracellular transport#GO:0046907;vesicle transport along microtubule#GO:0047496;transport#GO:0006810;synaptic vesicle cycle#GO:0099504;vacuolar transport#GO:0007034;cytoskeleton-dependent intracellular transport#GO:0030705;synaptic vesicle recycling#GO:0036465;membrane organization#GO:0061024;axo-dendritic transport#GO:0008088;synaptic vesicle membrane organization#GO:0048499;macromolecule localization#GO:0033036;vesicle localization#GO:0051648;cellular localization#GO:0051641;protein transport#GO:0015031;post-Golgi vesicle-mediated transport#GO:0006892;lysosomal transport#GO:0007041;microtubule-based transport#GO:0099111;protein targeting#GO:0006605;establishment of organelle localization#GO:0051656;establishment of protein localization to vacuole#GO:0072666;cellular component organization#GO:0016043;protein localization to lysosome#GO:0061462;vesicle-mediated transport in synapse#GO:0099003;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;vesicle organization#GO:0016050;endosomal transport#GO:0016197;Golgi vesicle transport#GO:0048193;intracellular protein transport#GO:0006886;vesicle-mediated transport#GO:0016192;synaptic vesicle localization#GO:0097479;organelle transport along microtubule#GO:0072384;establishment of vesicle localization#GO:0051650;endomembrane system organization#GO:0010256;protein targeting to vacuole#GO:0006623;synaptic vesicle transport#GO:0048489;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184 bounding membrane of organelle#GO:0098588;AP-type membrane coat adaptor complex#GO:0030119;cell junction#GO:0030054;presynapse#GO:0098793;neuron projection#GO:0043005;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;endosome#GO:0005768;endosome membrane#GO:0010008;intracellular organelle#GO:0043229;coated membrane#GO:0048475;intracellular vesicle#GO:0097708;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;axon terminus#GO:0043679;organelle membrane#GO:0031090;membrane#GO:0016020;vesicle membrane#GO:0012506;endomembrane system#GO:0012505;axon#GO:0030424;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane coat#GO:0030117;vesicle#GO:0031982;membrane protein complex#GO:0098796;distal axon#GO:0150034;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;terminal bouton#GO:0043195;neuron projection terminus#GO:0044306 transporter#PC00227 HUMAN|HGNC=13247|UniProtKB=Q9NZB2 Q9NZB2 FAM120A PTHR15976:SF14 CONSTITUTIVE COACTIVATOR OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA CONSTITUTIVE COACTIVATOR OF PPAR-GAMMA-LIKE PROTEIN 1 HUMAN|HGNC=752|UniProtKB=O43681 O43681 GET3 PTHR10803:SF3 ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE ATPASE GET3 hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP-dependent activity#GO:0140657;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817 localization within membrane#GO:0051668;localization#GO:0051179;cellular localization#GO:0051641;cellular component organization#GO:0016043;protein insertion into ER membrane#GO:0045048;endoplasmic reticulum organization#GO:0007029;protein localization to organelle#GO:0033365;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;establishment of protein localization to membrane#GO:0090150;organelle organization#GO:0006996;macromolecule localization#GO:0033036;establishment of protein localization#GO:0045184;cellular process#GO:0009987;tail-anchored membrane protein insertion into ER membrane#GO:0071816;protein insertion into membrane#GO:0051205;membrane organization#GO:0061024;endomembrane system organization#GO:0010256 membrane-bounded organelle#GO:0043227;endoplasmic reticulum protein-containing complex#GO:0140534;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 transporter#PC00227 HUMAN|HGNC=2906|UniProtKB=Q9P1A6 Q9P1A6 DLGAP2 PTHR12353:SF3 DISKS LARGE-ASSOCIATED PROTEIN DAP SAP90/PSD-95-ASSOCIATED PROTEIN DISKS LARGE-ASSOCIATED PROTEIN 2 regulation of cellular process#GO:0050794;regulation of trans-synaptic signaling#GO:0099177;regulation of cell communication#GO:0010646;biological regulation#GO:0065007;modulation of chemical synaptic transmission#GO:0050804;regulation of signaling#GO:0023051;regulation of biological process#GO:0050789 postsynapse#GO:0098794;glutamatergic synapse#GO:0098978;cellular anatomical structure#GO:0110165;synapse#GO:0045202;postsynaptic specialization#GO:0099572;organelle#GO:0043226;cell junction#GO:0030054 scaffold/adaptor protein#PC00226 HUMAN|HGNC=19995|UniProtKB=Q6DWJ6 Q6DWJ6 GPR139 PTHR46272:SF3 G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN G PROTEIN-COUPLED RECEPTOR 139-RELATED G protein-coupled receptor signaling pathway#GO:0007186;phospholipase C-activating G protein-coupled receptor signaling pathway#GO:0007200;cell communication#GO:0007154;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007 HUMAN|HGNC=539|UniProtKB=A6NMY6 A6NMY6 ANXA2P2 PTHR10502:SF18 ANNEXIN ANNEXIN A2-RELATED ion binding#GO:0043167;phospholipid binding#GO:0005543;small molecule binding#GO:0036094;binding#GO:0005488;anion binding#GO:0043168;phosphatidylserine binding#GO:0001786;lipid binding#GO:0008289 positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;cell adhesion#GO:0007155;positive regulation of protein metabolic process#GO:0051247;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of proteolysis#GO:0030162;biological regulation#GO:0065007;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222 vesicle#GO:0031982;nucleus#GO:0005634;cell periphery#GO:0071944;vesicle membrane#GO:0012506;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622 calcium-binding protein#PC00060 HUMAN|HGNC=20340|UniProtKB=Q7Z3G6 Q7Z3G6 PRICKLE2 PTHR24211:SF18 LIM DOMAIN-CONTAINING PROTEIN PRICKLE-LIKE PROTEIN 2 cell development#GO:0048468;regulation of cellular component biogenesis#GO:0044087;cell projection organization#GO:0030030;regulation of cellular component organization#GO:0051128;cell differentiation#GO:0030154;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;regulation of postsynapse organization#GO:0099175;cellular component organization#GO:0016043;neuron development#GO:0048666;regulation of biological quality#GO:0065008;generation of neurons#GO:0048699;regulation of synapse organization#GO:0050807;animal gross anatomical part developmental process#GO:0160108;nervous system development#GO:0007399;cellular process#GO:0009987;neuron projection development#GO:0031175;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;neuron differentiation#GO:0030182;regulation of cellular process#GO:0050794;system development#GO:0048731;anatomical structure development#GO:0048856;regulation of synapse structure or activity#GO:0050803;regulation of cell junction assembly#GO:1901888;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;regulation of synapse assembly#GO:0051963;multicellular organismal process#GO:0032501;regulation of organelle assembly#GO:1902115;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;developmental process#GO:0032502 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HUMAN|HGNC=6691|UniProtKB=O75427 O75427 LRCH4 PTHR16083:SF9 LEUCINE RICH REPEAT CONTAINING PROTEIN LEUCINE-RICH REPEAT AND CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN 4 scaffold/adaptor protein#PC00226 HUMAN|HGNC=3465|UniProtKB=P10768 P10768 ESD PTHR10061:SF0 S-FORMYLGLUTATHIONE HYDROLASE S-FORMYLGLUTATHIONE HYDROLASE catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;thiolester hydrolase activity#GO:0016790;hydrolase activity#GO:0016787 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;serine protease#PC00203 HUMAN|HGNC=12994|UniProtKB=O95125 O95125 ZNF202 PTHR23226:SF195 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER PROTEIN 202 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=21044|UniProtKB=Q9BZ72 Q9BZ72 PITPNM2 PTHR10658:SF41 PHOSPHATIDYLINOSITOL TRANSFER PROTEIN MEMBRANE-ASSOCIATED PHOSPHATIDYLINOSITOL TRANSFER PROTEIN 2 lipid binding#GO:0008289;lipid transfer activity#GO:0120013;molecular carrier activity#GO:0140104;binding#GO:0005488;transporter activity#GO:0005215;intramembrane lipid carrier activity#GO:0140303;cation binding#GO:0043169;lipid carrier activity#GO:0005319;phosphatidylcholine intramembrane carrier activity#GO:0008525;ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;phosphatidylcholine binding#GO:0031210;phosphatidylinositol transfer activity#GO:0008526;phospholipid binding#GO:0005543;phosphatidylinositol binding#GO:0035091 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 transporter#PC00227 HUMAN|HGNC=52278|UniProtKB=A0A0J9YY54 A0A0J9YY54 TEX13D PTHR23111:SF28 ZINC FINGER PROTEIN TESTIS-EXPRESSED PROTEIN 13D mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 HUMAN|HGNC=18600|UniProtKB=Q96RT8 Q96RT8 TUBGCP5 PTHR19302:SF33 GAMMA TUBULIN COMPLEX PROTEIN GAMMA-TUBULIN COMPLEX COMPONENT 5 cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;microtubule binding#GO:0008017;binding#GO:0005488;protein binding#GO:0005515 cytoplasmic microtubule organization#GO:0031122;mitotic cell cycle#GO:0000278;reproductive process#GO:0022414;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;cell cycle#GO:0007049;microtubule nucleation#GO:0007020;cell cycle process#GO:0022402;protein-containing complex assembly#GO:0065003;protein polymerization#GO:0051258;microtubule cytoskeleton organization#GO:0000226;supramolecular fiber organization#GO:0097435;organelle assembly#GO:0070925;sexual reproduction#GO:0019953;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;spindle assembly#GO:0051225;microtubule polymerization or depolymerization#GO:0031109;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;spindle organization#GO:0007051;protein-containing complex organization#GO:0043933;microtubule-based process#GO:0007017;microtubule polymerization#GO:0046785;meiotic cell cycle#GO:0051321;chromosome segregation#GO:0007059 cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;microtubule cytoskeleton#GO:0015630;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232 non-motor microtubule binding protein#PC00166;cytoskeletal protein#PC00085 HUMAN|HGNC=10719|UniProtKB=Q13228 Q13228 SELENBP1 PTHR23300:SF0 METHANETHIOL OXIDASE METHANETHIOL OXIDASE defense/immunity protein#PC00090 HUMAN|HGNC=31369|UniProtKB=Q8N4H5 Q8N4H5 TOMM5 PTHR28436:SF1 MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM5 HOMOLOG MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM5 HOMOLOG primary active transporter#PC00068;transporter#PC00227 HUMAN|HGNC=4382|UniProtKB=O95837 O95837 GNA14 PTHR10218:SF213 GTP-BINDING PROTEIN ALPHA SUBUNIT GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14 ribonucleoside triphosphate phosphatase activity#GO:0017111;molecular function regulator activity#GO:0098772;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924 cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;cellular process#GO:0009987;G protein-coupled dopamine receptor signaling pathway#GO:0007212;biological regulation#GO:0065007;response to chemical#GO:0042221;cellular response to nitrogen compound#GO:1901699;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;regulation of membrane potential#GO:0042391;regulation of biological process#GO:0050789;action potential#GO:0001508;cellular response to stimulus#GO:0051716;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;response to oxygen-containing compound#GO:1901700;phospholipase C-activating G protein-coupled receptor signaling pathway#GO:0007200;G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887;response to nitrogen compound#GO:1901698;regulation of biological quality#GO:0065008;cell communication#GO:0007154 intracellular anatomical structure#GO:0005622;side of membrane#GO:0098552;catalytic complex#GO:1902494;extrinsic component of cytoplasmic side of plasma membrane#GO:0031234;cellular anatomical structure#GO:0110165;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;cytoplasmic side of plasma membrane#GO:0009898;extrinsic component of membrane#GO:0019898;extrinsic component of plasma membrane#GO:0019897;cytoplasmic side of membrane#GO:0098562;plasma membrane#GO:0005886;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020 heterotrimeric G-protein#PC00117;G-protein#PC00020 PI3 kinase pathway#P00048>Galpha#P01199;Wnt signaling pathway#P00057>Galpha#P01451;5HT2 type receptor mediated signaling pathway#P04374>G-protein#P04416;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Gqalpha#P00732;Thyrotropin-releasing hormone receptor signaling pathway#P04394>G-Protein#P04584;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Galphai/q#P00873;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Galphaq#P00826;Endothelin signaling pathway#P00019>Gq#P00586;Oxytocin receptor mediated signaling pathway#P04391>G-Protein#P04534;Histamine H1 receptor mediated signaling pathway#P04385>G-Protein#P04488;Cortocotropin releasing factor receptor signaling pathway#P04380>G-Protein#P04458;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>G-Protein#P01073 HUMAN|HGNC=28127|UniProtKB=Q9BU20 Q9BU20 CPLANE2 PTHR14983:SF1 CILIOGENESIS AND PLANAR POLARITY EFFECTOR 2 CILIOGENESIS AND PLANAR POLARITY EFFECTOR 2 hydrolase activity, acting on acid anhydrides#GO:0016817;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787 cell projection organization#GO:0030030;cilium assembly#GO:0060271;cellular component organization#GO:0016043;axoneme assembly#GO:0035082;cilium organization#GO:0044782;microtubule cytoskeleton organization#GO:0000226;microtubule bundle formation#GO:0001578;organelle assembly#GO:0070925;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cell projection assembly#GO:0030031;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection assembly#GO:0120031 plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cilium#GO:0005929;intracellular organelle#GO:0043229;ciliary transition zone#GO:0035869;centriole#GO:0005814;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815 HUMAN|HGNC=8005|UniProtKB=O60462 O60462 NRP2 PTHR46806:SF2 F5/8 TYPE C DOMAIN-CONTAINING PROTEIN NEUROPILIN-2 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;neurogenesis#GO:0022008;neuron projection guidance#GO:0097485;cell projection morphogenesis#GO:0048858;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;neuron differentiation#GO:0030182;multicellular organismal process#GO:0032501;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;axon development#GO:0061564;axon guidance#GO:0007411;neuron projection development#GO:0031175;cellular process#GO:0009987;anatomical structure development#GO:0048856;axonogenesis#GO:0007409;neuron development#GO:0048666;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell development#GO:0048468;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653 plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;glutamatergic synapse#GO:0098978;synapse#GO:0045202;plasma membrane#GO:0005886;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;postsynapse#GO:0098794;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;cell junction#GO:0030054;postsynaptic membrane#GO:0045211;axon#GO:0030424;synaptic membrane#GO:0097060 HUMAN|HGNC=8692|UniProtKB=Q9Y5E2 Q9Y5E2 PCDHB7 PTHR24028:SF69 CADHERIN-87A PROTOCADHERIN BETA-7 cellular process#GO:0009987;cell adhesion#GO:0007155 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cadherin#PC00057;cell adhesion molecule#PC00069 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HUMAN|HGNC=3379|UniProtKB=O43491 O43491 EPB41L2 PTHR23280:SF17 4.1 G PROTEIN BAND 4.1-LIKE PROTEIN 2 cell junction#GO:0030054;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;anchoring junction#GO:0070161;membrane#GO:0016020;cell-cell junction#GO:0005911;cell periphery#GO:0071944 actin or actin-binding cytoskeletal protein#PC00041;non-motor actin binding protein#PC00165;cytoskeletal protein#PC00085 Dopamine receptor mediated signaling pathway#P05912>EPB41L2#P05952;Nicotine pharmacodynamics pathway#P06587>EPB41L2#P06598;Dopamine receptor mediated signaling pathway#P05912>EPB41#P05966 HUMAN|HGNC=1189|UniProtKB=O95433 O95433 AHSA1 PTHR13009:SF7 HEAT SHOCK PROTEIN 90 HSP90 CO-CHAPERONE AHA-1 ACTIVATOR OF 90 KDA HEAT SHOCK PROTEIN ATPASE HOMOLOG 1 molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;ATPase activator activity#GO:0001671 primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein maturation#GO:0051604;gene expression#GO:0010467;protein folding#GO:0006457;biosynthetic process#GO:0009058;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 chaperone#PC00072 HUMAN|HGNC=23842|UniProtKB=Q8N961 Q8N961 ABTB2 PTHR46071:SF3 ANKYRIN REPEAT AND BTB/POZ DOMAIN-CONTAINING ANKYRIN REPEAT AND BTB_POZ DOMAIN-CONTAINING PROTEIN 2 scaffold/adaptor protein#PC00226 HUMAN|HGNC=17408|UniProtKB=Q6NZY7 Q6NZY7 CDC42EP5 PTHR15344:SF15 CDC42 EFFECTOR PROTEIN BORG CDC42 EFFECTOR PROTEIN 5 small GTPase binding#GO:0031267;protein binding#GO:0005515;enzyme binding#GO:0019899;binding#GO:0005488 regulation of cellular process#GO:0050794;regulation of cytoskeleton organization#GO:0051493;regulation of protein polymerization#GO:0032271;regulation of developmental process#GO:0050793;cellular response to stimulus#GO:0051716;regulation of supramolecular fiber organization#GO:1902903;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of cell projection assembly#GO:0060491;positive regulation of cell projection organization#GO:0031346;regulation of actin filament polymerization#GO:0030833;positive regulation of protein polymerization#GO:0032273;biological regulation#GO:0065007;regulation of actin polymerization or depolymerization#GO:0008064;small GTPase-mediated signal transduction#GO:0007264;regulation of actin filament organization#GO:0110053;positive regulation of cellular process#GO:0048522;regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of actin filament-based process#GO:0032970;regulation of cell projection organization#GO:0031344;response to stimulus#GO:0050896;regulation of cellular component organization#GO:0051128;regulation of plasma membrane bounded cell projection assembly#GO:0120032;regulation of cellular component biogenesis#GO:0044087;signaling#GO:0023052;regulation of protein-containing complex assembly#GO:0043254;cellular component organization#GO:0016043;regulation of cell shape#GO:0008360;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of cellular component size#GO:0032535;Rho protein signal transduction#GO:0007266;positive regulation of organelle organization#GO:0010638;regulation of biological quality#GO:0065008;regulation of actin filament length#GO:0030832;positive regulation of cellular component organization#GO:0051130;positive regulation of cellular component biogenesis#GO:0044089;intracellular signaling cassette#GO:0141124;regulation of actin cytoskeleton organization#GO:0032956;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;regulation of anatomical structure morphogenesis#GO:0022603;cellular component organization or biogenesis#GO:0071840;regulation of anatomical structure size#GO:0090066 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HUMAN|HGNC=28870|UniProtKB=Q9P1T7 Q9P1T7 MDFIC PTHR15304:SF0 MYOD FAMILY INHIBITOR MYOD FAMILY INHIBITOR DOMAIN-CONTAINING PROTEIN regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of Wnt signaling pathway#GO:0030111;regulation of cell communication#GO:0010646;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of biosynthetic process#GO:0009890;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of response to stimulus#GO:0048583;regulation of MAPK cascade#GO:0043408;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of JNK cascade#GO:0046328 membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 HUMAN|HGNC=840|UniProtKB=P24539 P24539 ATP5PB PTHR12733:SF3 MITOCHONDRIAL ATP SYNTHASE B CHAIN ATP SYNTHASE PERIPHERAL STALK SUBUNIT B, MITOCHONDRIAL monoatomic cation channel activity#GO:0005261;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;proton channel activity#GO:0015252;proton transmembrane transporter activity#GO:0015078;catalytic activity#GO:0003824;passive transmembrane transporter activity#GO:0022803;ligase activity#GO:0016874;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic cation transmembrane transporter activity#GO:0008324;proton-transporting ATP synthase activity, rotational mechanism#GO:0046933;channel activity#GO:0015267 ribonucleotide metabolic process#GO:0009259;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;nucleotide biosynthetic process#GO:0009165;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;small molecule metabolic process#GO:0044281;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;ATP biosynthetic process#GO:0006754;ribonucleoside triphosphate biosynthetic process#GO:0009201;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;ribose phosphate biosynthetic process#GO:0046390;ribose phosphate metabolic process#GO:0019693;ATP metabolic process#GO:0046034;cellular process#GO:0009987;organophosphate biosynthetic process#GO:0090407;primary metabolic process#GO:0044238;purine nucleoside triphosphate metabolic process#GO:0009144;purine nucleoside triphosphate biosynthetic process#GO:0009145;nucleoside triphosphate metabolic process#GO:0009141;nucleoside phosphate metabolic process#GO:0006753;proton motive force-driven ATP synthesis#GO:0015986;nucleoside phosphate biosynthetic process#GO:1901293;nucleoside triphosphate biosynthetic process#GO:0009142;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;purine ribonucleoside triphosphate metabolic process#GO:0009205;carbohydrate derivative metabolic process#GO:1901135;purine ribonucleoside triphosphate biosynthetic process#GO:0009206;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;proton-transporting ATP synthase complex#GO:0045259;organelle#GO:0043226;mitochondrion#GO:0005739;organelle envelope#GO:0031967;membrane protein complex#GO:0098796;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transmembrane transporter complex#GO:1902495;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;respiratory chain complex#GO:0098803;mitochondrial membrane#GO:0031966;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;organelle membrane#GO:0031090;transporter complex#GO:1990351;proton-transporting two-sector ATPase complex#GO:0016469;cation channel complex#GO:0034703 primary active transporter#PC00068;ATP synthase#PC00002 HUMAN|HGNC=7778|UniProtKB=Q14934 Q14934 NFATC4 PTHR12533:SF11 NFAT NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4 double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 cellular response to stimulus#GO:0051716;calcineurin-mediated signaling#GO:0097720;calcineurin-NFAT signaling cascade#GO:0033173;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;intracellular signal transduction#GO:0035556;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;cell communication#GO:0007154;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;calcium-mediated signaling#GO:0019722;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;signaling#GO:0023052;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;intracellular signaling cassette#GO:0141124;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of transcription by RNA polymerase II#GO:0045944 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 Rel homology transcription factor#PC00252;gene-specific transcriptional regulator#PC00264;immunoglobulin fold transcription factor#PC00251 Wnt signaling pathway#P00057>NFAT#P01452;B cell activation#P00010>NFAT#P00367;Axon guidance mediated by netrin#P00009>NFAT#P00359;T cell activation#P00053>NFAT#P01294;Gonadotropin-releasing hormone receptor pathway#P06664>NFAT#P06777;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>NFAT#P00851 HUMAN|HGNC=8942|UniProtKB=P48595 P48595 SERPINB10 PTHR11461:SF175 SERINE PROTEASE INHIBITOR, SERPIN SERPIN B10 molecular function inhibitor activity#GO:0140678;serine-type endopeptidase inhibitor activity#GO:0004867;enzyme regulator activity#GO:0030234;peptidase regulator activity#GO:0061134;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414;molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866;enzyme inhibitor activity#GO:0004857 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HUMAN|HGNC=3223|UniProtKB=P52797 P52797 EFNA3 PTHR11304:SF5 EPHRIN EPHRIN-A3 protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488 biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;multicellular organismal process#GO:0032501;axon development#GO:0061564;axon guidance#GO:0007411;neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;regulation of cellular process#GO:0050794;ephrin receptor signaling pathway#GO:0048013;cellular response to stimulus#GO:0051716;system development#GO:0048731;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;signal transduction#GO:0007165;cellular process#GO:0009987;neuron projection development#GO:0031175;cell projection morphogenesis#GO:0048858;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;neuron differentiation#GO:0030182;cell surface receptor signaling pathway#GO:0007166;plasma membrane bounded cell projection morphogenesis#GO:0120039;signaling#GO:0023052;cell development#GO:0048468;cell projection organization#GO:0030030;cell differentiation#GO:0030154;response to stimulus#GO:0050896;cell morphogenesis#GO:0000902;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;neuron development#GO:0048666;axonogenesis#GO:0007409;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 membrane-bound signaling molecule#PC00152;intercellular signal molecule#PC00207 HUMAN|HGNC=8189|UniProtKB=P30953 P30953 OR1E1 PTHR48001:SF187 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 1E1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=3313|UniProtKB=Q12926 Q12926 ELAVL2 PTHR10352:SF12 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G ELAV-LIKE PROTEIN 2 nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 translational protein#PC00263;translation factor#PC00223;translation initiation factor#PC00224 HUMAN|HGNC=17798|UniProtKB=P49750 P49750 YLPM1 PTHR13413:SF0 YLP MOTIF CONTAINING PROTEIN NUCLEAR PROTEIN ZAP YLP MOTIF-CONTAINING PROTEIN 1 regulation of telomere maintenance#GO:0032204;regulation of chromosome organization#GO:0033044;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of organelle organization#GO:0033043;regulation of DNA metabolic process#GO:0051052;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA metabolism protein#PC00009 HUMAN|HGNC=1835|UniProtKB=P49716 P49716 CEBPD PTHR23334:SF3 CCAAT/ENHANCER BINDING PROTEIN CCAAT_ENHANCER-BINDING PROTEIN DELTA sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of cell differentiation#GO:0045595;regulation of developmental process#GO:0050793;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 basic leucine zipper transcription factor#PC00056;DNA-binding transcription factor#PC00218 HUMAN|HGNC=14058|UniProtKB=Q8N6W0 Q8N6W0 CELF5 PTHR24012:SF728 RNA BINDING PROTEIN CUGBP ELAV-LIKE FAMILY MEMBER 5 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729 RNA metabolic process#GO:0016070;regulation of alternative mRNA splicing, via spliceosome#GO:0000381;nucleic acid biosynthetic process#GO:0141187;spliceosomal complex assembly#GO:0000245;mRNA metabolic process#GO:0016071;ribonucleoprotein complex biogenesis#GO:0022613;cellular component organization#GO:0016043;mRNA splicing, via spliceosome#GO:0000398;regulation of biological process#GO:0050789;protein-containing complex assembly#GO:0065003;cellular component organization or biogenesis#GO:0071840;protein-RNA complex organization#GO:0071826;regulation of mRNA metabolic process#GO:1903311;protein-containing complex organization#GO:0043933;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;cellular component assembly#GO:0022607;gene expression#GO:0010467;RNA processing#GO:0006396;mRNA splice site recognition#GO:0006376;mRNA processing#GO:0006397;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;protein-RNA complex assembly#GO:0022618;regulation of RNA metabolic process#GO:0051252;RNA splicing, via transesterification reactions#GO:0000375;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of mRNA splicing, via spliceosome#GO:0048024;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of mRNA processing#GO:0050684;regulation of RNA splicing#GO:0043484;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;macromolecule biosynthetic process#GO:0009059 nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HUMAN|HGNC=6481|UniProtKB=P25391 P25391 LAMA1 PTHR10574:SF409 NETRIN/LAMININ-RELATED LAMININ SUBUNIT ALPHA-1 extracellular matrix structural constituent#GO:0005201;structural molecule activity#GO:0005198 neuron development#GO:0048666;axonogenesis#GO:0007409;eye development#GO:0001654;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;circulatory system development#GO:0072359;cell differentiation#GO:0030154;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;blood vessel morphogenesis#GO:0048514;vasculature development#GO:0001944;cell projection morphogenesis#GO:0048858;animal organ development#GO:0048513;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;cellular process#GO:0009987;sensory system development#GO:0048880;neuron projection development#GO:0031175;system development#GO:0048731;anatomical structure development#GO:0048856;camera-type eye development#GO:0043010;visual system development#GO:0150063;tube morphogenesis#GO:0035239;blood vessel development#GO:0001568;neurogenesis#GO:0022008;neuron projection guidance#GO:0097485;cellular developmental process#GO:0048869;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;sensory organ development#GO:0007423;plasma membrane bounded cell projection organization#GO:0120036;tube development#GO:0035295;tissue development#GO:0009888;multicellular organismal process#GO:0032501;axon guidance#GO:0007411;axon development#GO:0061564 basement membrane#GO:0005604;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cellular anatomical structure#GO:0110165 extracellular matrix protein#PC00102 Integrin signalling pathway#P00034>Laminin#P00947 HUMAN|HGNC=16785|UniProtKB=Q5T5J6 Q5T5J6 SWT1 PTHR16161:SF0 TRANSCRIPTIONAL PROTEIN SWT1 TRANSCRIPTIONAL PROTEIN SWT1 catalytic activity, acting on RNA#GO:0140098;RNA endonuclease activity#GO:0004521;RNA nuclease activity#GO:0004540;nuclease activity#GO:0004518;endonuclease activity#GO:0004519;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640 catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;nucleic acid metabolic process#GO:0090304;negative regulation of gene expression#GO:0010629;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;RNA metabolic process#GO:0016070;RNA catabolic process#GO:0006401;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;nuclear mRNA surveillance#GO:0071028;nucleobase-containing compound catabolic process#GO:0034655;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;nucleic acid catabolic process#GO:0141188;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of gene expression#GO:0010468;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;negative regulation of cellular process#GO:0048523 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=16699|UniProtKB=Q9UPU3 Q9UPU3 SORCS3 PTHR12106:SF10 SORTILIN RELATED VPS10 DOMAIN-CONTAINING RECEPTOR SORCS3 vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;localization#GO:0051179;post-Golgi vesicle-mediated transport#GO:0006892;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193;transport#GO:0006810 cell junction#GO:0030054;Golgi apparatus#GO:0005794;synaptic membrane#GO:0097060;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;endomembrane system#GO:0012505;neuron to neuron synapse#GO:0098984;plasma membrane#GO:0005886;cytoplasm#GO:0005737;membrane#GO:0016020;cell periphery#GO:0071944;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;postsynaptic density membrane#GO:0098839;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;intracellular organelle#GO:0043229;postsynaptic density#GO:0014069;organelle#GO:0043226;asymmetric synapse#GO:0032279;cellular anatomical structure#GO:0110165;synapse#GO:0045202;intracellular membrane-bounded organelle#GO:0043231;postsynapse#GO:0098794 membrane traffic protein#PC00150 HUMAN|HGNC=6709|UniProtKB=P01374 P01374 LTA PTHR11471:SF31 TUMOR NECROSIS FACTOR FAMILY MEMBER LYMPHOTOXIN-ALPHA molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677;signaling receptor regulator activity#GO:0030545;cytokine activity#GO:0005125;receptor ligand activity#GO:0048018 positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;immune system process#GO:0002376;signaling#GO:0023052;positive regulation of programmed cell death#GO:0043068;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;regulation of programmed cell death#GO:0043067;positive regulation of canonical NF-kappaB signal transduction#GO:0043123;positive regulation of apoptotic process#GO:0043065;cell surface receptor signaling pathway#GO:0007166;regulation of apoptotic process#GO:0042981;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cell communication#GO:0007154;regulation of apoptotic signaling pathway#GO:2001233;regulation of cell communication#GO:0010646;positive regulation of apoptotic signaling pathway#GO:2001235;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;regulation of extrinsic apoptotic signaling pathway#GO:2001236;positive regulation of extrinsic apoptotic signaling pathway#GO:2001238;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of response to stimulus#GO:0048584;regulation of canonical NF-kappaB signal transduction#GO:0043122;positive regulation of cellular process#GO:0048522;immune response#GO:0006955 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>IL2#P00870;Apoptosis signaling pathway#P00006>TNF#P00259 HUMAN|HGNC=6667|UniProtKB=P08519 P08519 LPA PTHR20851:SF0 DORSAL INTERACTING PROTEIN 3 APOLIPOPROTEIN(A) Plasminogen activating cascade#P00050>Plasmin#P01246;Plasminogen activating cascade#P00050>Plasminogen#P01255 HUMAN|HGNC=10066|UniProtKB=Q3KNV8 Q3KNV8 PCGF3 PTHR45893:SF5 POLYCOMB GROUP RING FINGER PROTEIN POLYCOMB GROUP RING FINGER PROTEIN 3 regulation of biological process#GO:0050789;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of gene expression, epigenetic#GO:0045814;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;heterochromatin organization#GO:0070828;cellular component assembly#GO:0022607;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;heterochromatin formation#GO:0031507;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;chromatin organization#GO:0006325;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219 intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;PcG protein complex#GO:0031519;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 chromatin/chromatin-binding, or -regulatory protein#PC00077;histone modifying enzyme#PC00261 HUMAN|HGNC=17027|UniProtKB=Q8TF71 Q8TF71 SLC16A10 PTHR11360:SF119 MONOCARBOXYLATE TRANSPORTER MONOCARBOXYLATE TRANSPORTER 10 monocarboxylic acid transmembrane transporter activity#GO:0008028;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943 biological regulation#GO:0065007;regulation of biological quality#GO:0065008;localization#GO:0051179;establishment of localization#GO:0051234;transport#GO:0006810;regulation of hormone levels#GO:0010817;hormone transport#GO:0009914 cell periphery#GO:0071944;basal plasma membrane#GO:0009925;membrane#GO:0016020;basolateral plasma membrane#GO:0016323;basal part of cell#GO:0045178;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590 transporter#PC00227 HUMAN|HGNC=23377|UniProtKB=Q5VW36 Q5VW36 FOCAD PTHR16212:SF4 FOCADHESIN FAMILY MEMBER FOCADHESIN HUMAN|HGNC=3208|UniProtKB=P24534 P24534 EEF1B2 PTHR11595:SF60 EF-HAND AND COILED-COIL DOMAIN-CONTAINING FAMILY MEMBER ELONGATION FACTOR 1-BETA enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;translation#GO:0006412;translational elongation#GO:0006414;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 translation elongation factor#PC00222 HUMAN|HGNC=592|UniProtKB=P98170 P98170 XIAP PTHR10044:SF181 INHIBITOR OF APOPTOSIS E3 UBIQUITIN-PROTEIN LIGASE XIAP acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;enzyme regulator activity#GO:0030234;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;molecular function regulator activity#GO:0098772 regulation of macromolecule metabolic process#GO:0060255;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;positive regulation of signal transduction#GO:0009967;positive regulation of canonical Wnt signaling pathway#GO:0090263;regulation of protein modification process#GO:0031399;negative regulation of cellular process#GO:0048523;regulation of protein ubiquitination#GO:0031396;regulation of response to stimulus#GO:0048583;positive regulation of response to stimulus#GO:0048584;negative regulation of apoptotic process#GO:0043066;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;regulation of post-translational protein modification#GO:1901873;positive regulation of metabolic process#GO:0009893;positive regulation of signaling#GO:0023056;positive regulation of protein metabolic process#GO:0051247;regulation of signaling#GO:0023051;regulation of cell cycle#GO:0051726;regulation of Wnt signaling pathway#GO:0030111;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;regulation of protein modification by small protein conjugation or removal#GO:1903320;regulation of biological process#GO:0050789;regulation of apoptotic process#GO:0042981;positive regulation of Wnt signaling pathway#GO:0030177;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of protein ubiquitination#GO:0031398;regulation of protein metabolic process#GO:0051246;regulation of canonical Wnt signaling pathway#GO:0060828;negative regulation of programmed cell death#GO:0043069;positive regulation of biological process#GO:0048518 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 protein-binding activity modulator#PC00095;protease inhibitor#PC00191 Apoptosis signaling pathway#P00006>XIAP#P00304 HUMAN|HGNC=24142|UniProtKB=Q9BX74 Q9BX74 TM2D1 PTHR21016:SF1 BETA-AMYLOID BINDING PROTEIN-RELATED TM2 DOMAIN-CONTAINING PROTEIN 1 molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 regulation of response to stimulus#GO:0048583;apoptotic signaling pathway#GO:0097190;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;regulation of signaling#GO:0023051;regulation of Notch signaling pathway#GO:0008593;positive regulation of signaling#GO:0023056;cell communication#GO:0007154;apoptotic process#GO:0006915;cellular response to stimulus#GO:0051716;cell death#GO:0008219;regulation of biological process#GO:0050789;programmed cell death#GO:0012501;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;signaling#GO:0023052;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;response to stimulus#GO:0050896;positive regulation of Notch signaling pathway#GO:0045747 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=9235|UniProtKB=Q03181 Q03181 PPARD PTHR24082:SF15 NUCLEAR HORMONE RECEPTOR PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR DELTA sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription repressor activity#GO:0001217;transcription regulator activity#GO:0140110;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;molecular transducer activity#GO:0060089;DNA binding#GO:0003677;nuclear receptor activity#GO:0004879;transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227 cellular response to stimulus#GO:0051716;positive regulation of RNA metabolic process#GO:0051254;homeostatic process#GO:0042592;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of lipid metabolic process#GO:0019216;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of DNA-templated transcription#GO:0006355;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;positive regulation of biosynthetic process#GO:0009891;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;positive regulation of RNA biosynthetic process#GO:1902680;multicellular organismal process#GO:0032501;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;multicellular organismal-level homeostasis#GO:0048871;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;response to endogenous stimulus#GO:0009719;signaling#GO:0023052;negative regulation of metabolic process#GO:0009892;cellular response to hormone stimulus#GO:0032870;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;cellular response to chemical stimulus#GO:0070887;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;hormone-mediated signaling pathway#GO:0009755;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;response to hormone#GO:0009725;negative regulation of macromolecule biosynthetic process#GO:0010558;positive regulation of macromolecule metabolic process#GO:0010604;response to chemical#GO:0042221;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;positive regulation of transcription by RNA polymerase II#GO:0045944 intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 C4 zinc finger nuclear receptor#PC00169 Wnt signaling pathway#P00057>Wnt Target Genes#G01558 HUMAN|HGNC=23174|UniProtKB=Q7Z5L7 Q7Z5L7 PODN PTHR45712:SF20 AGAP008170-PA PODOCAN cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=2531|UniProtKB=Q9UBX1 Q9UBX1 CTSF PTHR12411:SF444 CYSTEINE PROTEASE FAMILY C1-RELATED CATHEPSIN F cysteine-type endopeptidase activity#GO:0004197;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234 cellular process#GO:0009987;primary metabolic process#GO:0044238;catabolic process#GO:0009056;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;extracellular region#GO:0005576;vacuole#GO:0005773;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 protease#PC00190;protein modifying enzyme#PC00260;cysteine protease#PC00081 HUMAN|HGNC=9070|UniProtKB=P08567 P08567 PLEK PTHR12092:SF1 PLECKSTRIN PLECKSTRIN cytoskeleton organization#GO:0007010;cellular component organization or biogenesis#GO:0071840;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987;actin filament-based process#GO:0030029;organelle organization#GO:0006996;cellular component organization#GO:0016043 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 cytoskeletal protein#PC00085 HUMAN|HGNC=863|UniProtKB=O15342 O15342 ATP6V0E1 PTHR12263:SF5 VACUOLAR ATP SYNTHASE SUBUNIT H V-TYPE PROTON ATPASE SUBUNIT E 1 active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399;monoatomic ion transmembrane transporter activity#GO:0015075;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;proton transmembrane transporter activity#GO:0015078;monoatomic cation transmembrane transporter activity#GO:0008324;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829 transport#GO:0006810;monoatomic ion transport#GO:0006811;proton transmembrane transport#GO:1902600;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220 catalytic complex#GO:1902494;intracellular organelle#GO:0043229;vacuolar proton-transporting V-type ATPase complex#GO:0016471;ATPase complex#GO:1904949;transmembrane transporter complex#GO:1902495;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ATPase dependent transmembrane transport complex#GO:0098533;membrane protein complex#GO:0098796;cation-transporting ATPase complex#GO:0090533;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;proton-transporting two-sector ATPase complex#GO:0016469;transporter complex#GO:1990351;vacuolar membrane#GO:0005774;proton-transporting V-type ATPase complex#GO:0033176;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane#GO:0016020;protein-containing complex#GO:0032991;vacuole#GO:0005773;cytoplasm#GO:0005737 primary active transporter#PC00068;ATP synthase#PC00002 HUMAN|HGNC=16234|UniProtKB=Q8NI51 Q8NI51 CTCFL PTHR24406:SF36 TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED TRANSCRIPTIONAL REPRESSOR CTCFL C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HUMAN|HGNC=5123|UniProtKB=O43248 O43248 HOXC11 PTHR46092:SF1 HOMEOBOX PROTEIN HOX-A11-RELATED HOMEOBOX PROTEIN HOX-C11 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;animal organ morphogenesis#GO:0009887;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;animal gross anatomical part developmental process#GO:0160108;chordate embryonic development#GO:0043009;embryonic organ development#GO:0048568;embryo development ending in birth or egg hatching#GO:0009792;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;skeletal system development#GO:0001501;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;skeletal system morphogenesis#GO:0048705;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;embryo development#GO:0009790;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;animal organ development#GO:0048513;embryonic morphogenesis#GO:0048598;multicellular organism development#GO:0007275;regulation of gene expression#GO:0010468 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 homeodomain transcription factor#PC00119 HUMAN|HGNC=5246|UniProtKB=P04792 P04792 HSPB1 PTHR45640:SF7 HEAT SHOCK PROTEIN HSP-12.2-RELATED HEAT SHOCK PROTEIN BETA-1 protein metabolic process#GO:0019538;protein refolding#GO:0042026;primary metabolic process#GO:0044238;response to abiotic stimulus#GO:0009628;response to stimulus#GO:0050896;protein folding#GO:0006457;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;response to heat#GO:0009408;response to stress#GO:0006950;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;response to temperature stimulus#GO:0009266 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 chaperone#PC00072 p38 MAPK pathway#P05918>HSP27#P06016;VEGF signaling pathway#P00056>HSP27#P01412;CCKR signaling map#P06959>HSP27#P07154;Angiogenesis#P00005>HSP27#P00231 HUMAN|HGNC=3296|UniProtKB=Q04637 Q04637 EIF4G1 PTHR23253:SF10 EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 1 translation initiation factor activity#GO:0003743;RNA binding#GO:0003723;translation factor activity#GO:0180051;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729 gene expression#GO:0010467;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;translation#GO:0006412;translational initiation#GO:0006413 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 translation initiation factor#PC00224 HUMAN|HGNC=10808|UniProtKB=O43556 O43556 SGCE PTHR10132:SF17 ALPHA-/EPSILON-SARCOGLYCAN FAMILY MEMBER EPSILON-SARCOGLYCAN protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;dystrophin-associated glycoprotein complex#GO:0016010;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944 cadherin#PC00057 HUMAN|HGNC=23243|UniProtKB=Q9NQR7 Q9NQR7 CCDC177 PTHR33663:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 177 COILED-COIL DOMAIN-CONTAINING PROTEIN 177 HUMAN|HGNC=17862|UniProtKB=Q9H4L4 Q9H4L4 SENP3 PTHR12606:SF16 SENTRIN/SUMO-SPECIFIC PROTEASE SENTRIN-SPECIFIC PROTEASE 3 cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783 macromolecule metabolic process#GO:0043170;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152;post-translational protein modification#GO:0043687;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein modification process#GO:0036211 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 protease#PC00190 HUMAN|HGNC=23604|UniProtKB=P26371 P26371 KRTAP5-9 PTHR23262:SF131 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 5-9 structural protein#PC00211 HUMAN|HGNC=17199|UniProtKB=Q9UIG4 Q9UIG4 PSORS1C2 PTHR31853:SF1 PSORIASIS SUSCEPTIBILITY 1 CANDIDATE GENE 2 PROTEIN PSORIASIS SUSCEPTIBILITY 1 CANDIDATE GENE 2 PROTEIN HUMAN|HGNC=34352|UniProtKB=Q0P641 Q0P641 C2orf80 PTHR36296:SF1 GAMMA-CRYSTALLIN A CHROMOSOME 15 C2ORF80 HOMOLOG structural protein#PC00211 HUMAN|HGNC=55809|UniProtKB=A0A7I2V3R4 A0A7I2V3R4 RNF228 PTHR22791:SF17 RING-TYPE DOMAIN-CONTAINING PROTEIN RING FINGER PROTEIN 228 aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746 metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein modification process#GO:0036211;primary metabolic process#GO:0044238;cellular process#GO:0009987;protein modification by small protein conjugation#GO:0032446;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=8113|UniProtKB=Q14990 Q14990 ODF1 PTHR17125:SF2 OUTER DENSE FIBER PROTEIN 1 OUTER DENSE FIBER PROTEIN 1 microtubule cytoskeleton#GO:0015630;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;motile cilium#GO:0031514;cellular anatomical structure#GO:0110165;sperm flagellum#GO:0036126;cilium#GO:0005929;9+2 motile cilium#GO:0097729;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 HUMAN|HGNC=28859|UniProtKB=Q9Y5L2 Q9Y5L2 HILPDA PTHR16886:SF0 HYPOXIA-INDUCIBLE PROTEIN 2 HYPOXIA-INDUCIBLE LIPID DROPLET-ASSOCIATED PROTEIN protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488 regulation of biological process#GO:0050789;cellular process#GO:0009987;cell-cell signaling#GO:0007267;signaling#GO:0023052;biological regulation#GO:0065007;cell communication#GO:0007154 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=15169|UniProtKB=Q8NGP0 Q8NGP0 OR4C13 PTHR48002:SF7 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 4C13 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=4395|UniProtKB=P19086 P19086 GNAZ PTHR10218:SF65 GTP-BINDING PROTEIN ALPHA SUBUNIT GUANINE NUCLEOTIDE-BINDING PROTEIN G(Z) SUBUNIT ALPHA molecular function regulator activity#GO:0098772;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818 adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 extrinsic component of cytoplasmic side of plasma membrane#GO:0031234;catalytic complex#GO:1902494;side of membrane#GO:0098552;intracellular anatomical structure#GO:0005622;cytoplasmic side of plasma membrane#GO:0009898;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cellular anatomical structure#GO:0110165;cytoplasmic side of membrane#GO:0098562;extrinsic component of plasma membrane#GO:0019897;extrinsic component of membrane#GO:0019898;membrane#GO:0016020;cell periphery#GO:0071944;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;plasma membrane#GO:0005886 heterotrimeric G-protein#PC00117;G-protein#PC00020 Dopamine receptor mediated signaling pathway#P05912>GNAZ#P05964 HUMAN|HGNC=23476|UniProtKB=Q9H7D0 Q9H7D0 DOCK5 PTHR45653:SF3 DEDICATOR OF CYTOKINESIS DEDICATOR OF CYTOKINESIS PROTEIN 5 molecular function regulator activity#GO:0098772;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme binding#GO:0019899;binding#GO:0005488;guanyl-nucleotide exchange factor activity#GO:0005085;protein binding#GO:0005515;small GTPase binding#GO:0031267;enzyme regulator activity#GO:0030234 cell differentiation#GO:0030154;cell motility#GO:0048870;muscle structure development#GO:0061061;cell migration#GO:0016477;muscle cell differentiation#GO:0042692;cellular process#GO:0009987;myoblast fusion#GO:0007520;striated muscle cell differentiation#GO:0051146;syncytium formation by cell-cell fusion#GO:0000768;anatomical structure development#GO:0048856;cellular developmental process#GO:0048869;developmental process#GO:0032502;cell-cell fusion#GO:0140253;animal gross anatomical part developmental process#GO:0160108 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 G-protein modulator#PC00022;protein-binding activity modulator#PC00095;guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=26125|UniProtKB=Q8TB22 Q8TB22 SPATA20 PTHR42899:SF1 SPERMATOGENESIS-ASSOCIATED PROTEIN 20 SPERMATOGENESIS-ASSOCIATED PROTEIN 20 HUMAN|HGNC=356|UniProtKB=Q9Y4K1 Q9Y4K1 CRYBG1 PTHR11818:SF2 BETA/GAMMA CRYSTALLIN BETA_GAMMA CRYSTALLIN DOMAIN-CONTAINING PROTEIN 1 structural molecule activity#GO:0005198 system development#GO:0048731;eye development#GO:0001654;anatomical structure development#GO:0048856;sensory perception#GO:0007600;nervous system process#GO:0050877;camera-type eye development#GO:0043010;animal gross anatomical part developmental process#GO:0160108;visual system development#GO:0150063;visual perception#GO:0007601;sensory perception of light stimulus#GO:0050953;system process#GO:0003008;multicellular organism development#GO:0007275;animal organ development#GO:0048513;lens development in camera-type eye#GO:0002088;developmental process#GO:0032502;sensory organ development#GO:0007423;multicellular organismal process#GO:0032501;sensory system development#GO:0048880 structural protein#PC00211 HUMAN|HGNC=17039|UniProtKB=Q4ZIN3 Q4ZIN3 TMEM259 PTHR21650:SF4 MEMBRALIN/KINETOCHORE PROTEIN NUF2 MEMBRALIN regulation of response to stress#GO:0080134;regulation of response to stimulus#GO:0048583;positive regulation of catabolic process#GO:0009896;regulation of catabolic process#GO:0009894;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;response to stress#GO:0006950;regulation of protein metabolic process#GO:0051246;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of proteasomal protein catabolic process#GO:0061136;positive regulation of response to stimulus#GO:0048584;positive regulation of macromolecule metabolic process#GO:0010604;biological regulation#GO:0065007;response to endoplasmic reticulum stress#GO:0034976;cellular response to stress#GO:0033554;positive regulation of protein metabolic process#GO:0051247;positive regulation of metabolic process#GO:0009893;positive regulation of protein catabolic process#GO:0045732;regulation of cellular response to stress#GO:0080135;regulation of protein catabolic process#GO:0042176;positive regulation of proteasomal protein catabolic process#GO:1901800;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;regulation of response to endoplasmic reticulum stress#GO:1905897;regulation of macromolecule metabolic process#GO:0060255;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of ERAD pathway#GO:1904292 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 microtubule or microtubule-binding cytoskeletal protein#PC00157;non-motor microtubule binding protein#PC00166 HUMAN|HGNC=14683|UniProtKB=Q9Y2G5 Q9Y2G5 POFUT2 PTHR13398:SF0 GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 2 GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 2 catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757;transferase activity#GO:0016740;catalytic activity#GO:0003824;fucosyltransferase activity#GO:0008417;hexosyltransferase activity#GO:0016758 glycosyltransferase#PC00111 HUMAN|HGNC=48335|UniProtKB=Q5H9J9 Q5H9J9 TCP11X2 PTHR12832:SF21 TESTIS-SPECIFIC PROTEIN PBS13 T-COMPLEX 11 T-COMPLEX PROTEIN 11-LIKE X-LINKED PROTEIN 1-RELATED response to stimulus#GO:0050896;regulation of reproductive process#GO:2000241;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of developmental process#GO:0050793;signaling#GO:0023052;regulation of multicellular organismal process#GO:0051239;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of cell development#GO:0060284;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;regulation of cell differentiation#GO:0045595 cytoplasm#GO:0005737;endomembrane system#GO:0012505;sperm flagellum#GO:0036126;secretory vesicle#GO:0099503;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;9+2 motile cilium#GO:0097729;cilium#GO:0005929;intracellular organelle#GO:0043229;acrosomal vesicle#GO:0001669;cell projection#GO:0042995;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;motile cilium#GO:0031514;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708 microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=13310|UniProtKB=Q9NZD1 Q9NZD1 GPRC5D PTHR14511:SF16 G PROTEIN COUPLED RECEPTOR, CLASS C, GROUP 5 G PROTEIN-COUPLED RECEPTOR FAMILY C GROUP 5 MEMBER D kinase activator activity#GO:0019209;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;protein kinase activator activity#GO:0030295;enzyme activator activity#GO:0008047;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;protein kinase regulator activity#GO:0019887 signaling receptor complex#GO:0043235;extracellular region#GO:0005576;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cell periphery#GO:0071944;vesicle#GO:0031982;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 G-protein coupled receptor#PC00021 HUMAN|HGNC=145|UniProtKB=P63267 P63267 ACTG2 PTHR11937:SF201 ACTIN ACTIN, GAMMA-ENTERIC SMOOTH MUSCLE structural molecule activity#GO:0005198;structural constituent of cytoskeleton#GO:0005200 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;extracellular region#GO:0005576;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;actin cytoskeleton#GO:0015629 actin and actin related protein#PC00039 Huntington disease#P00029>Actin#P00807;Integrin signalling pathway#P00034>Actin#P00944;Nicotinic acetylcholine receptor signaling pathway#P00044>Actin#P01090;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>F-actin#P00858;Cadherin signaling pathway#P00012>F-actin#P00470;Wnt signaling pathway#P00057>NFAT Target Genes#G01559;Cytoskeletal regulation by Rho GTPase#P00016>Actin#P00512;Alzheimer disease-presenilin pathway#P00004>actin#P00114 HUMAN|HGNC=20156|UniProtKB=Q96JJ6 Q96JJ6 JPH4 PTHR23085:SF14 GH28348P JUNCTOPHILIN-4 regulation of trans-synaptic signaling#GO:0099177;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;biological regulation#GO:0065007;modulation of chemical synaptic transmission#GO:0050804;regulation of biological process#GO:0050789;regulation of biological quality#GO:0065008;regulation of synaptic plasticity#GO:0048167;regulation of signaling#GO:0023051 endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;sarcoplasm#GO:0016528;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;cell periphery#GO:0071944;membrane#GO:0016020;cytoplasm#GO:0005737;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;endomembrane system#GO:0012505 HUMAN|HGNC=11841|UniProtKB=Q9UKI8 Q9UKI8 TLK1 PTHR22974:SF22 MIXED LINEAGE PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE TOUSLED-LIKE 1 catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674 cell cycle#GO:0007049;cellular process#GO:0009987;cell cycle process#GO:0022402;chromosome segregation#GO:0007059 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=16095|UniProtKB=Q96NM4 Q96NM4 TOX2 PTHR45781:SF5 AGAP000281-PA TOX HIGH MOBILITY GROUP BOX FAMILY MEMBER 2 DNA binding#GO:0003677;chromatin DNA binding#GO:0031490;chromatin binding#GO:0003682;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;HMG box transcription factor#PC00024 HUMAN|HGNC=30183|UniProtKB=Q9BYD5 Q9BYD5 CNFN PTHR15907:SF26 DUF614 FAMILY PROTEIN-RELATED CORNIFELIN cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 HUMAN|HGNC=30576|UniProtKB=Q9BV57 Q9BV57 ADI1 PTHR23418:SF0 ACIREDUCTONE DIOXYGENASE ACIREDUCTONE DIOXYGENASE oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen#GO:0016702;oxidoreductase activity#GO:0016491;dioxygenase activity#GO:0051213;catalytic activity#GO:0003824 metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;homocysteine metabolic process#GO:0050667;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;sulfur compound metabolic process#GO:0006790;amino acid metabolic process#GO:0006520;nucleobase-containing compound metabolic process#GO:0006139;proteinogenic amino acid metabolic process#GO:0170039;purine nucleoside metabolic process#GO:0042278;oxoacid metabolic process#GO:0043436;purine-containing compound metabolic process#GO:0072521;primary metabolic process#GO:0044238;modified amino acid metabolic process#GO:0006575;carboxylic acid metabolic process#GO:0019752;nucleoside metabolic process#GO:0009116;small molecule metabolic process#GO:0044281 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 oxidoreductase#PC00176;oxygenase#PC00177 HUMAN|HGNC=12945|UniProtKB=P17019 P17019 ZNF708 PTHR23232:SF124 KRAB DOMAIN C2H2 ZINC FINGER ZINC FINGER PROTEIN 708 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=23620|UniProtKB=Q9H665 Q9H665 IGFLR1 PTHR14657:SF2 IGF-LIKE FAMILY RECEPTOR 1 IGF-LIKE FAMILY RECEPTOR 1 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=16076|UniProtKB=Q9BYG4 Q9BYG4 PARD6G PTHR14102:SF3 PAR-6-RELATED PARTITIONING DEFECTIVE 6 HOMOLOG GAMMA protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 establishment or maintenance of cell polarity#GO:0007163;cell-cell junction organization#GO:0045216;cell-cell junction maintenance#GO:0045217;microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;microtubule organizing center organization#GO:0031023;cellular component organization#GO:0016043;cell cycle#GO:0007049;organelle organization#GO:0006996;cellular process#GO:0009987;cell cycle process#GO:0022402;centrosome cycle#GO:0007098;cell junction organization#GO:0034330;cytoskeleton organization#GO:0007010 membrane#GO:0016020;nucleus#GO:0005634;cell periphery#GO:0071944;protein-containing complex#GO:0032991;plasma membrane region#GO:0098590;cytoplasm#GO:0005737;plasma membrane#GO:0005886;transferase complex#GO:1990234;apical part of cell#GO:0045177;protein kinase complex#GO:1902911;apical plasma membrane#GO:0016324;cell cortex#GO:0005938;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554 cell junction protein#PC00070;tight junction#PC00214 HUMAN|HGNC=10838|UniProtKB=Q15464 Q15464 SHB PTHR15127:SF31 HEAVYWEIGHT, ISOFORM A SH2 DOMAIN-CONTAINING ADAPTER PROTEIN B binding#GO:0005488;protein binding#GO:0005515 HUMAN|HGNC=12424|UniProtKB=O00295 O00295 TULP2 PTHR16517:SF24 TUBBY-RELATED TUBBY-RELATED PROTEIN 2 macromolecule localization#GO:0033036;protein localization to organelle#GO:0033365;localization#GO:0051179;protein localization to cilium#GO:0061512;intracellular protein localization#GO:0008104 cilium#GO:0005929;plasma membrane bounded cell projection#GO:0120025;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226 scaffold/adaptor protein#PC00226 HUMAN|HGNC=1639|UniProtKB=P06729 P06729 CD2 PTHR12080:SF54 SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE T-CELL SURFACE ANTIGEN CD2 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell communication#GO:0007154;cell activation#GO:0001775;immune system process#GO:0002376;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;leukocyte activation#GO:0045321;T cell activation#GO:0042110;biological regulation#GO:0065007;lymphocyte activation#GO:0046649;multicellular organismal process#GO:0032501;signal transduction#GO:0007165;immune response#GO:0006955;cellular process#GO:0009987 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=4417|UniProtKB=P46926 P46926 GNPDA1 PTHR11280:SF8 GLUCOSAMINE-6-PHOSPHATE ISOMERASE GLUCOSAMINE-6-PHOSPHATE DEAMINASE 1 binding#GO:0005488;catalytic activity#GO:0003824;identical protein binding#GO:0042802;deaminase activity#GO:0019239;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;protein binding#GO:0005515;hydrolase activity#GO:0016787 amino sugar catabolic process#GO:0046348;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;amino sugar metabolic process#GO:0006040;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;carbohydrate derivative catabolic process#GO:1901136;small molecule catabolic process#GO:0044282;carboxylic acid metabolic process#GO:0019752;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;carboxylic acid catabolic process#GO:0046395 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 isomerase#PC00135 N-acetylglucosamine metabolism#P02756>Glucosamine-6-phosphate deaminase#P03041 HUMAN|HGNC=31690|UniProtKB=Q8TCD1 Q8TCD1 C18orf32 PTHR13456:SF0 UPF0729 PROTEIN C18ORF32 UPF0729 PROTEIN C18ORF32 HUMAN|HGNC=2465|UniProtKB=O14594 O14594 NCAN PTHR22804:SF24 AGGRECAN/VERSICAN PROTEOGLYCAN NEUROCAN CORE PROTEIN anatomical structure development#GO:0048856;skeletal system development#GO:0001501;multicellular organism development#GO:0007275;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502;multicellular organismal process#GO:0032501;central nervous system development#GO:0007417;nervous system development#GO:0007399 extracellular region#GO:0005576;cell junction#GO:0030054;membrane#GO:0016020;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;synapse#GO:0045202;plasma membrane#GO:0005886 extracellular matrix protein#PC00102;extracellular matrix glycoprotein#PC00100 HUMAN|HGNC=3003|UniProtKB=Q9BZG8 Q9BZG8 DPH1 PTHR10762:SF1 DIPHTHAMIDE BIOSYNTHESIS PROTEIN 2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1 cellular process#GO:0009987;metabolic process#GO:0008152;protein modification process#GO:0036211;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412 HUMAN|HGNC=34452|UniProtKB=A8MTZ7 A8MTZ7 C12orf71 PTHR36462:SF1 CHROMOSOME 12 OPEN READING FRAME 71 CHROMOSOME 11 C12ORF71 HOMOLOG HUMAN|HGNC=10763|UniProtKB=Q9BYH1 Q9BYH1 SEZ6L PTHR45656:SF8 PROTEIN CBR-CLEC-78 SEIZURE 6-LIKE PROTEIN cellular process#GO:0009987;developmental maturation#GO:0021700;brain development#GO:0007420;multicellular organismal process#GO:0032501;head development#GO:0060322;nervous system development#GO:0007399;developmental process#GO:0032502;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;animal organ development#GO:0048513;cellular component organization#GO:0016043;central nervous system development#GO:0007417;cell junction organization#GO:0034330;animal gross anatomical part developmental process#GO:0160108;synapse organization#GO:0050808;anatomical structure development#GO:0048856;system development#GO:0048731 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;cytoplasm#GO:0005737;plasma membrane region#GO:0098590;endomembrane system#GO:0012505;synaptic membrane#GO:0097060;endoplasmic reticulum#GO:0005783;cell junction#GO:0030054;cell body#GO:0044297;postsynapse#GO:0098794;neuronal cell body#GO:0043025;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;postsynaptic membrane#GO:0045211;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=9113|UniProtKB=P29590 P29590 PML PTHR25462:SF302 BONUS, ISOFORM C-RELATED PROTEIN PML acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;SUMO transferase activity#GO:0019789;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 biological regulation#GO:0065007;response to other organism#GO:0051707;immune response#GO:0006955;response to external stimulus#GO:0009605;defense response#GO:0006952;apoptotic signaling pathway#GO:0097190;innate immune response#GO:0045087;DNA damage response#GO:0006974;response to external biotic stimulus#GO:0043207;regulation of cellular process#GO:0050794;cell death#GO:0008219;cellular response to stimulus#GO:0051716;programmed cell death#GO:0012501;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;response to virus#GO:0009615;defense response to other organism#GO:0098542;signal transduction#GO:0007165;defense response to symbiont#GO:0140546;cellular process#GO:0009987;intrinsic apoptotic signaling pathway in response to DNA damage#GO:0008630;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;apoptotic process#GO:0006915;defense response to virus#GO:0051607;intrinsic apoptotic signaling pathway#GO:0097193;cellular response to stress#GO:0033554;immune system process#GO:0002376 nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;nuclear body#GO:0016604;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228;organelle lumen#GO:0043233;PML body#GO:0016605;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 ubiquitin-protein ligase#PC00234 p53 pathway#P00059>PML#P04618;p53 pathway#P00059>PML#G04701 HUMAN|HGNC=9317|UniProtKB=P63098 P63098 PPP3R1 PTHR45942:SF3 Calcineurin subunit B CALCINEURIN SUBUNIT B TYPE 1 protein binding#GO:0005515;enzyme regulator activity#GO:0030234;protein phosphatase regulator activity#GO:0019888;binding#GO:0005488;phosphatase binding#GO:0019902;enzyme binding#GO:0019899;phosphatase regulator activity#GO:0019208;molecular function regulator activity#GO:0098772 calcium-mediated signaling#GO:0019722;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;calcineurin-NFAT signaling cascade#GO:0033173;calcineurin-mediated signaling#GO:0097720;biological regulation#GO:0065007;signaling#GO:0023052;intracellular signaling cassette#GO:0141124;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 catalytic complex#GO:1902494;protein serine/threonine phosphatase complex#GO:0008287;protein-containing complex#GO:0032991;intracellular protein-containing complex#GO:0140535 Wnt signaling pathway#P00057>Calcineurin#P01446 HUMAN|HGNC=3016|UniProtKB=O14531 O14531 DPYSL4 PTHR11647:SF55 HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER DIHYDROPYRIMIDINASE-RELATED PROTEIN 4 dihydropyrimidinase activity#GO:0004157;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides#GO:0016812;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810 pyrimidine nucleobase metabolic process#GO:0006206;nucleobase metabolic process#GO:0009112;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;nucleobase catabolic process#GO:0046113;nucleobase-containing compound metabolic process#GO:0006139;pyrimidine nucleobase catabolic process#GO:0006208;primary metabolic process#GO:0044238;pyrimidine-containing compound metabolic process#GO:0072527;cellular process#GO:0009987 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 hydrolase#PC00121 Axon guidance mediated by semaphorins#P00007>CRMP#P00339 HUMAN|HGNC=26359|UniProtKB=A1KZ92 A1KZ92 PXDNL PTHR11475:SF38 OXIDASE/PEROXIDASE OXIDOREDUCTASE PXDNL-RELATED catalytic activity#GO:0003824;peroxidase activity#GO:0004601;antioxidant activity#GO:0016209;oxidoreductase activity, acting on peroxide as acceptor#GO:0016684;oxidoreductase activity#GO:0016491 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 metabolite interconversion enzyme#PC00262;peroxidase#PC00180 HUMAN|HGNC=25467|UniProtKB=Q96ST2 Q96ST2 IWS1 PTHR46010:SF1 PROTEIN IWS1 HOMOLOG PROTEIN IWS1 HOMOLOG nuclear transport#GO:0051169;nuclear export#GO:0051168;localization#GO:0051179;nucleic acid transport#GO:0050657;cellular localization#GO:0051641;mRNA export from nucleus#GO:0006406;nucleocytoplasmic transport#GO:0006913;mRNA transport#GO:0051028;establishment of RNA localization#GO:0051236;nucleobase-containing compound transport#GO:0015931;RNA localization#GO:0006403;RNA transport#GO:0050658;macromolecule metabolic process#GO:0043170;poly(A)+ mRNA export from nucleus#GO:0016973;establishment of localization#GO:0051234;transport#GO:0006810;metabolic process#GO:0008152;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;biosynthetic process#GO:0009058;gene expression#GO:0010467;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule localization#GO:0033036;nitrogen compound transport#GO:0071705 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=4709|UniProtKB=P10144 P10144 GZMB PTHR24271:SF81 KALLIKREIN-RELATED GRANZYME B hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;serine-type peptidase activity#GO:0008236;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity#GO:0003824 metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;signal transduction#GO:0007165;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;biological regulation#GO:0065007;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604;cell communication#GO:0007154;protein metabolic process#GO:0019538;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell death#GO:0008219;programmed cell death#GO:0012501;primary metabolic process#GO:0044238;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 serine protease#PC00203 Apoptosis signaling pathway#P00006>Granzyme B#P00265 HUMAN|HGNC=25091|UniProtKB=Q86VM9 Q86VM9 ZC3H18 PTHR46582:SF1 ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 18 ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 18 HUMAN|HGNC=25001|UniProtKB=Q8NCP5 Q8NCP5 ZBTB44 PTHR24383:SF20 ZINC FINGER PROTEIN ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 44 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=11471|UniProtKB=Q8IYB8 Q8IYB8 SUPV3L1 PTHR12131:SF31 ATP-DEPENDENT RNA AND DNA HELICASE ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL mitochondrial RNA 3'-end processing#GO:0000965;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mitochondrial RNA processing#GO:0000963;RNA 3'-end processing#GO:0031123;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mitochondrial gene expression#GO:0140053;RNA metabolic process#GO:0016070;mitochondrial RNA metabolic process#GO:0000959;nucleic acid biosynthetic process#GO:0141187 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA metabolism protein#PC00009 HUMAN|HGNC=14840|UniProtKB=Q8NGM9 Q8NGM9 OR8D4 PTHR48018:SF137 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 8D4 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cellular process#GO:0009987;signal transduction#GO:0007165;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signaling#GO:0023052;sensory perception of smell#GO:0007608;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;nervous system process#GO:0050877;sensory perception#GO:0007600;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=11092|UniProtKB=P03973 P03973 SLPI PTHR19441:SF44 WAP four-disulfide core domain protein ANTILEUKOPROTEINASE peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;peptidase regulator activity#GO:0061134;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;serine-type endopeptidase inhibitor activity#GO:0004867;enzyme inhibitor activity#GO:0004857;endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772 antibacterial humoral response#GO:0019731;innate immune response#GO:0045087;defense response#GO:0006952;response to external stimulus#GO:0009605;antimicrobial humoral response#GO:0019730;humoral immune response#GO:0006959;defense response to other organism#GO:0098542;response to other organism#GO:0051707;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;defense response to symbiont#GO:0140546;immune response#GO:0006955;response to bacterium#GO:0009617;immune system process#GO:0002376;defense response to bacterium#GO:0042742;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease inhibitor#PC00191 HUMAN|HGNC=37168|UniProtKB=S4R3Y5 S4R3Y5 MTRNR2L11 PTHR33895:SF16 HUMANIN-LIKE 4 HUMANIN-LIKE 11 signaling receptor inhibitor activity#GO:0030547;molecular function inhibitor activity#GO:0140678;molecular function regulator activity#GO:0098772;signaling receptor regulator activity#GO:0030545 regulation of apoptotic process#GO:0042981;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;negative regulation of apoptotic process#GO:0043066;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of programmed cell death#GO:0043069;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067 HUMAN|HGNC=651|UniProtKB=P15514 P15514 AREG PTHR10740:SF12 TRANSFORMING GROWTH FACTOR ALPHA AMPHIREGULIN protein binding#GO:0005515;molecular function activator activity#GO:0140677;binding#GO:0005488;signaling receptor binding#GO:0005102;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;growth factor receptor binding#GO:0070851;growth factor activity#GO:0008083 positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of mitotic cell cycle#GO:0007346;ERBB signaling pathway#GO:0038127;epidermal growth factor receptor signaling pathway#GO:0007173;regulation of cell cycle process#GO:0010564;biological regulation#GO:0065007;regulation of nuclear division#GO:0051783;positive regulation of cell cycle#GO:0045787;positive regulation of mitotic nuclear division#GO:0045840;cell surface receptor signaling pathway#GO:0007166;regulation of mitotic nuclear division#GO:0007088;positive regulation of cell population proliferation#GO:0008284;regulation of biological process#GO:0050789;positive regulation of cell cycle process#GO:0090068;regulation of organelle organization#GO:0033043;cellular response to stimulus#GO:0051716;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of cell cycle#GO:0051726;positive regulation of cellular component organization#GO:0051130;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;positive regulation of organelle organization#GO:0010638;enzyme-linked receptor protein signaling pathway#GO:0007167 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 growth factor#PC00112 EGF receptor signaling pathway#P00018>EGF#P00549 HUMAN|HGNC=14671|UniProtKB=Q9H9F9 Q9H9F9 ACTR5 PTHR11937:SF16 ACTIN ACTIN-RELATED PROTEIN 5 enzyme regulator activity#GO:0030234;structural molecule activity#GO:0005198;molecular function regulator activity#GO:0098772;structural constituent of cytoskeleton#GO:0005200 regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468;regulation of nucleobase-containing compound metabolic process#GO:0019219;chromatin organization#GO:0006325;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;chromatin remodeling#GO:0006338;cellular component organization#GO:0016043;regulation of biological process#GO:0050789 cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;protein-containing complex#GO:0032991;chromatin#GO:0000785;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;Ino80 complex#GO:0031011;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;SWI/SNF superfamily-type complex#GO:0070603;organelle lumen#GO:0043233;chromosome#GO:0005694;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;INO80-type complex#GO:0097346;ATPase complex#GO:1904949;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013 actin and actin related protein#PC00039 HUMAN|HGNC=11066|UniProtKB=Q9UHI5 Q9UHI5 SLC7A8 PTHR11785:SF113 AMINO ACID TRANSPORTER LARGE NEUTRAL AMINO ACIDS TRANSPORTER SMALL SUBUNIT 2 L-amino acid transmembrane transporter activity#GO:0015179;amino acid transmembrane transporter activity#GO:0015171;neutral L-amino acid transmembrane transporter activity#GO:0015175;carboxylic acid transmembrane transporter activity#GO:0046943;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 cellular process#GO:0009987;transport#GO:0006810;amino acid transport#GO:0006865;localization#GO:0051179;neutral amino acid transport#GO:0015804;amino acid transmembrane transport#GO:0003333;establishment of localization#GO:0051234;transmembrane transport#GO:0055085 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227 HUMAN|HGNC=16489|UniProtKB=Q8WYN0 Q8WYN0 ATG4A PTHR22624:SF35 CYSTEINE PROTEASE ATG4 CYSTEINE PROTEASE ATG4A protein-phosphatidylethanolamide deconjugating activity#GO:0019786;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;cysteine-type endopeptidase activity#GO:0004197;catalytic activity, acting on a protein#GO:0140096;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;hydrolase activity#GO:0016787 catabolic process#GO:0009056;piecemeal microautophagy of the nucleus#GO:0034727;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;vacuole organization#GO:0007033;process utilizing autophagic mechanism#GO:0061919;proteolysis#GO:0006508;organelle assembly#GO:0070925;cellular component assembly#GO:0022607;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;macroautophagy#GO:0016236;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;autophagy#GO:0006914;protein processing#GO:0016485;autophagosome organization#GO:1905037;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;mitophagy#GO:0000423;autophagosome assembly#GO:0000045;metabolic process#GO:0008152;autophagy of mitochondrion#GO:0000422 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 cysteine protease#PC00081 HUMAN|HGNC=28499|UniProtKB=Q8TAG5 Q8TAG5 VSTM2A PTHR12207:SF23 V-SET AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN V-SET AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 2A membrane#GO:0016020;cellular anatomical structure#GO:0110165 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=23098|UniProtKB=Q9NVK5 Q9NVK5 FGFR1OP2 PTHR12186:SF3 SIKE FAMILY MEMBER FGFR1 ONCOGENE PARTNER 2 response to stimulus#GO:0050896;response to wounding#GO:0009611;response to stress#GO:0006950 HUMAN|HGNC=11449|UniProtKB=P53597 P53597 SUCLG1 PTHR11117:SF2 SUCCINYL-COA LIGASE SUBUNIT ALPHA SUCCINATE--COA LIGASE [ADP_GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL ligase activity, forming carbon-sulfur bonds#GO:0016877;catalytic activity#GO:0003824;ligase activity#GO:0016874 aerobic respiration#GO:0009060;energy derivation by oxidation of organic compounds#GO:0015980;cellular respiration#GO:0045333;generation of precursor metabolites and energy#GO:0006091;metabolic process#GO:0008152;cellular process#GO:0009987;primary metabolic process#GO:0044238;tricarboxylic acid cycle#GO:0006099 organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;catalytic complex#GO:1902494 metabolite interconversion enzyme#PC00262;ligase#PC00142 TCA cycle#P00051>Succinyl CoA Synthetase#P01274 HUMAN|HGNC=21492|UniProtKB=Q8N0U8 Q8N0U8 VKORC1L1 PTHR14519:SF5 VITAMIN K EPOXIDE REDUCTASE COMPLEX, SUBUNIT 1 VITAMIN K EPOXIDE REDUCTASE COMPLEX SUBUNIT 1-LIKE PROTEIN 1 catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 cellular process#GO:0009987;metabolic process#GO:0008152;vitamin K metabolic process#GO:0042373;ketone metabolic process#GO:0042180 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=20244|UniProtKB=Q8N118 Q8N118 CYP4X1 PTHR24291:SF63 CYTOCHROME P450 FAMILY 4 CYTOCHROME P450 4X1-RELATED oxygenase#PC00177;metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HUMAN|HGNC=8714|UniProtKB=Q9Y5F8 Q9Y5F8 PCDHGB7 PTHR24028:SF113 CADHERIN-87A PROTOCADHERIN GAMMA-B7 cellular process#GO:0009987;cell adhesion#GO:0007155 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 cadherin#PC00057;cell adhesion molecule#PC00069 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HUMAN|HGNC=24618|UniProtKB=Q8WYP5 Q8WYP5 AHCTF1 PTHR21583:SF8 ELYS PROTEIN PROTEIN ELYS scaffold/adaptor protein#PC00226 HUMAN|HGNC=12784|UniProtKB=P41221 P41221 WNT5A PTHR12027:SF33 WNT RELATED PROTEIN WNT-5A signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;frizzled binding#GO:0005109;G protein-coupled receptor binding#GO:0001664;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;molecular function activator activity#GO:0140677;protein binding#GO:0005515;cytokine activity#GO:0005125;signaling receptor binding#GO:0005102;binding#GO:0005488 cell surface receptor signaling pathway#GO:0007166;neuron differentiation#GO:0030182;developmental process#GO:0032502;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;cellular process#GO:0009987;signal transduction#GO:0007165;nervous system development#GO:0007399;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cell fate commitment#GO:0045165;system development#GO:0048731;anatomical structure development#GO:0048856;canonical Wnt signaling pathway#GO:0060070;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signaling#GO:0023052;regulation of cellular process#GO:0050794;Wnt signaling pathway#GO:0016055;response to stimulus#GO:0050896;cell differentiation#GO:0030154 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 Alzheimer disease-presenilin pathway#P00004>Wnt#P00142;Wnt signaling pathway#P00057>Wnt#P01444;Cadherin signaling pathway#P00012>Wnt#P00474;Angiogenesis#P00005>Wnt#P00206 HUMAN|HGNC=20978|UniProtKB=Q96RI8 Q96RI8 TAAR6 PTHR24249:SF271 HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR TRACE AMINE-ASSOCIATED RECEPTOR 6 transmembrane signaling receptor activity#GO:0004888;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HUMAN|HGNC=8617|UniProtKB=P23760 P23760 PAX3 PTHR45636:SF17 PAIRED BOX PROTEIN PAX-6-RELATED-RELATED PAIRED BOX PROTEIN PAX-3 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;nervous system development#GO:0007399;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;developmental process#GO:0032502;regulation of gene expression#GO:0010468;multicellular organism development#GO:0007275;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 HUMAN|HGNC=30843|UniProtKB=Q8IX05 Q8IX05 CD302 PTHR22803:SF144 MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED CD302 ANTIGEN membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=29406|UniProtKB=Q96N64 Q96N64 PWWP2A PTHR23068:SF4 DNA CYTOSINE-5- -METHYLTRANSFERASE 3-RELATED PWWP DOMAIN-CONTAINING PROTEIN 2A protein binding#GO:0005515;binding#GO:0005488;chromatin binding#GO:0003682;histone binding#GO:0042393 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 DNA methyltransferase#PC00013 HUMAN|HGNC=42959|UniProtKB=Q92843 Q92843 BCL2L2 PTHR11256:SF13 BCL-2 RELATED BCL-2-LIKE PROTEIN 2 passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;channel activity#GO:0015267 positive regulation of cellular process#GO:0048522;negative regulation of apoptotic process#GO:0043066;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;DNA damage response#GO:0006974;apoptotic signaling pathway#GO:0097190;programmed cell death#GO:0012501;cell death#GO:0008219;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;organelle organization#GO:0006996;intrinsic apoptotic signaling pathway in response to DNA damage#GO:0008630;response to stress#GO:0006950;negative regulation of programmed cell death#GO:0043069;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;mitochondrion organization#GO:0007005;apoptotic mitochondrial changes#GO:0008637;cell surface receptor signaling pathway#GO:0007166;regulation of apoptotic process#GO:0042981;positive regulation of apoptotic process#GO:0043065;cellular component organization or biogenesis#GO:0071840;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;apoptotic process#GO:0006915;response to stimulus#GO:0050896;extrinsic apoptotic signaling pathway#GO:0097191;positive regulation of programmed cell death#GO:0043068;release of cytochrome c from mitochondria#GO:0001836;signaling#GO:0023052;cellular response to stress#GO:0033554;intrinsic apoptotic signaling pathway#GO:0097193 mitochondrial outer membrane#GO:0005741;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane#GO:0016020;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;organelle outer membrane#GO:0031968;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;outer membrane#GO:0019867;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle envelope#GO:0031967;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 Apoptosis signaling pathway#P00006>Bcl-w#P00316 HUMAN|HGNC=30542|UniProtKB=Q8TEQ0 Q8TEQ0 SNX29 PTHR47194:SF4 SORTING NEXIN-29-RELATED SORTING NEXIN-29 scaffold/adaptor protein#PC00226 HUMAN|Ensembl=ENSG00000273748.1|UniProtKB=A0AAG2SWP8 A0AAG2SWP8 PTHR12928:SF4 FRG1 PROTEIN FRG1 protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;catalytic step 2 spliceosome#GO:0071013;membraneless organelle#GO:0043228;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;spliceosomal complex#GO:0005681;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleolus#GO:0005730;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494 RNA splicing factor#PC00148 HUMAN|HGNC=1873|UniProtKB=Q9UEE9 Q9UEE9 CFDP1 PTHR48407:SF1 CRANIOFACIAL DEVELOPMENT PROTEIN 1 HETEROCHROMATIN-STABILIZING PROTEIN CFDP1 cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;chromatin organization#GO:0006325;chromatin remodeling#GO:0006338 membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;chromatin#GO:0000785;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;histone deacetylase complex#GO:0000118;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;protein-containing complex#GO:0032991;ATPase complex#GO:1904949;Swr1 complex#GO:0000812;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;INO80-type complex#GO:0097346;SWI/SNF superfamily-type complex#GO:0070603;chromosome#GO:0005694;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226 HUMAN|HGNC=2674|UniProtKB=P53355 P53355 DAPK1 PTHR24342:SF17 SERINE/THREONINE-PROTEIN KINASE 17 DEATH-ASSOCIATED PROTEIN KINASE 1 phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;regulation of apoptotic process#GO:0042981;positive regulation of apoptotic process#GO:0043065;regulation of programmed cell death#GO:0043067;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;positive regulation of programmed cell death#GO:0043068;regulation of cellular process#GO:0050794;signaling#GO:0023052;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=12789|UniProtKB=Q93098 Q93098 WNT8B PTHR12027:SF94 WNT RELATED PROTEIN WNT-8B signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;G protein-coupled receptor binding#GO:0001664;frizzled binding#GO:0005109;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;cytokine activity#GO:0005125;binding#GO:0005488;signaling receptor binding#GO:0005102;protein binding#GO:0005515;molecular function activator activity#GO:0140677 signaling#GO:0023052;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;Wnt signaling pathway#GO:0016055;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;system development#GO:0048731;cell fate commitment#GO:0045165;anatomical structure development#GO:0048856;canonical Wnt signaling pathway#GO:0060070;cell communication#GO:0007154;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;nervous system development#GO:0007399;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;cellular process#GO:0009987;signal transduction#GO:0007165;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;cell surface receptor signaling pathway#GO:0007166;developmental process#GO:0032502;neuron differentiation#GO:0030182 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 Cadherin signaling pathway#P00012>Wnt#P00474;Wnt signaling pathway#P00057>Wnt#P01444;Alzheimer disease-presenilin pathway#P00004>Wnt#P00142 HUMAN|HGNC=47|UniProtKB=Q9NP58 Q9NP58 ABCB6 PTHR24221:SF664 ATP-BINDING CASSETTE SUB-FAMILY B ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 6 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657;active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399 localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;cellular process#GO:0009987;transport#GO:0006810 intracellular organelle#GO:0043229;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;membrane-bounded organelle#GO:0043227;vacuolar membrane#GO:0005774;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;vacuole#GO:0005773;cellular anatomical structure#GO:0110165;organelle#GO:0043226 ATP-binding cassette (ABC) transporter#PC00003 HUMAN|HGNC=21221|UniProtKB=Q96NJ5 Q96NJ5 KLHL32 PTHR45632:SF45 LD33804P KELCH-LIKE PROTEIN 32 enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152 Cul3-RING ubiquitin ligase complex#GO:0031463;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;catalytic complex#GO:1902494 scaffold/adaptor protein#PC00226 HUMAN|HGNC=34450|UniProtKB=Q69YU5 Q69YU5 UQCC6 PTHR28492:SF1 HYPOTHETICAL PROTEIN LOC691921 UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX ASSEMBLY FACTOR 6 cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;mitochondrion organization#GO:0007005;mitochondrial respiratory chain complex assembly#GO:0033108;mitochondrial respiratory chain complex III assembly#GO:0034551;cellular component assembly#GO:0022607;cytochrome complex assembly#GO:0017004;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739 HUMAN|HGNC=30616|UniProtKB=P60008 P60008 H1-9P PTHR11467:SF181 HISTONE H1 HISTONE H1.9-RELATED protein-containing complex binding#GO:0044877;nucleosome binding#GO:0031491;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;chromatin binding#GO:0003682;binding#GO:0005488;nucleic acid binding#GO:0003676;chromatin DNA binding#GO:0031490 chromosome condensation#GO:0030261;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of DNA recombination#GO:0000018;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of metabolic process#GO:0009892;negative regulation of DNA recombination#GO:0045910;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;regulation of DNA metabolic process#GO:0051052;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;chromosome organization#GO:0051276;negative regulation of cellular process#GO:0048523;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of DNA metabolic process#GO:0051053;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;organelle organization#GO:0006996;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=7511|UniProtKB=Q9H3R2 Q9H3R2 MUC13 PTHR24037:SF10 HEART DEVELOPMENT PROTEIN WITH EGF-LIKE DOMAINS 1 MUCIN-13 HUMAN|HGNC=1242|UniProtKB=P02746 P02746 C1QB PTHR15427:SF18 EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER COMPLEMENT C1Q SUBCOMPONENT SUBUNIT B receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 regulation of immune system process#GO:0002682;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;immune system process#GO:0002376;regulation of immune response#GO:0050776;positive regulation of response to stimulus#GO:0048584;adaptive immune response#GO:0002250;biological regulation#GO:0065007;positive regulation of immune system process#GO:0002684;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;immune response#GO:0006955;complement activation#GO:0006956;humoral immune response#GO:0006959;regulation of response to stimulus#GO:0048583;immune effector process#GO:0002252;positive regulation of immune response#GO:0050778 plasma membrane#GO:0005886;presynaptic membrane#GO:0042734;plasma membrane region#GO:0098590;protein-containing complex#GO:0032991;glutamatergic synapse#GO:0098978;presynapse#GO:0098793;cell periphery#GO:0071944;membrane#GO:0016020;cell junction#GO:0030054;extrinsic component of membrane#GO:0019898;extrinsic component of plasma membrane#GO:0019897;extracellular protein-containing complex#GO:0140392;synaptic membrane#GO:0097060;cellular anatomical structure#GO:0110165;synapse#GO:0045202;extracellular region#GO:0005576 scaffold/adaptor protein#PC00226 HUMAN|HGNC=15235|UniProtKB=Q8NGF1 Q8NGF1 OR52R1 PTHR26450:SF156 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 52R1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=8541|UniProtKB=P41231 P41231 P2RY2 PTHR24231:SF17 PURINOCEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR P2Y PURINOCEPTOR 2 molecular transducer activity#GO:0060089;protein binding#GO:0005515;transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488;signaling receptor binding#GO:0005102;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;G protein-coupled receptor binding#GO:0001664 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=44141|UniProtKB=P0DJR0 P0DJR0 GIMD1 PTHR10903:SF103 GTPASE, IMAP FAMILY MEMBER-RELATED GTPASE IMAP FAMILY MEMBER GIMD1 pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111 small GTPase#PC00208 HUMAN|HGNC=20106|UniProtKB=Q8N966 Q8N966 ZDHHC22 PTHR22883:SF213 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE ZDHHC22 acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;palmitoyltransferase activity#GO:0016409 localization#GO:0051179;cellular localization#GO:0051641;localization within membrane#GO:0051668;protein targeting#GO:0006605;cellular component organization#GO:0016043;vesicle organization#GO:0016050;cellular component organization or biogenesis#GO:0071840;synaptic vesicle maturation#GO:0016188;establishment of localization#GO:0051234;developmental process#GO:0032502;protein targeting to membrane#GO:0006612;developmental maturation#GO:0021700;establishment of protein localization#GO:0045184;cellular process#GO:0009987;establishment of protein localization to membrane#GO:0090150;organelle organization#GO:0006996 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 protein modifying enzyme#PC00260 HUMAN|HGNC=9879|UniProtKB=Q7LDG7 Q7LDG7 RASGRP2 PTHR23113:SF16 GUANINE NUCLEOTIDE EXCHANGE FACTOR RAS GUANYL-RELEASING PROTEIN 2 guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;signaling#GO:0023052;small GTPase-mediated signal transduction#GO:0007264;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;Ras protein signal transduction#GO:0007265 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 guanyl-nucleotide exchange factor#PC00113 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>CalDAG-GEF#P00736 HUMAN|HGNC=7000|UniProtKB=O00470 O00470 MEIS1 PTHR11850:SF126 HOMEOBOX PROTEIN TRANSCRIPTION FACTORS HOMEOBOX PROTEIN MEIS1 sequence-specific DNA binding#GO:0043565;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;DNA-binding transcription activator activity#GO:0001216;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;developmental process#GO:0032502;sensory organ development#GO:0007423;hemopoiesis#GO:0030097;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;tube development#GO:0035295;brain development#GO:0007420;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;regulation of cell population proliferation#GO:0042127;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;pattern specification process#GO:0007389;visual system development#GO:0150063;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;animal organ morphogenesis#GO:0009887;tube morphogenesis#GO:0035239;blood vessel development#GO:0001568;anatomical structure formation involved in morphogenesis#GO:0048646;vasculature development#GO:0001944;multicellular organism development#GO:0007275;animal organ development#GO:0048513;positive regulation of transcription by RNA polymerase II#GO:0045944;embryo development#GO:0009790;head development#GO:0060322;nervous system development#GO:0007399;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;embryonic pattern specification#GO:0009880;sensory system development#GO:0048880;eye development#GO:0001654;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;angiogenesis#GO:0001525;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;central nervous system development#GO:0007417;circulatory system development#GO:0072359;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;positive regulation of cell population proliferation#GO:0008284;blood vessel morphogenesis#GO:0048514 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 HUMAN|HGNC=29484|UniProtKB=Q8NFU7 Q8NFU7 TET1 PTHR23358:SF2 METHYLCYTOSINE DIOXYGENASE TET METHYLCYTOSINE DIOXYGENASE TET1 catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;oxidoreductase activity#GO:0016491;dioxygenase activity#GO:0051213;catalytic activity, acting on DNA#GO:0140097 regulation of RNA metabolic process#GO:0051252;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;positive regulation of RNA metabolic process#GO:0051254;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=4798|UniProtKB=Q14520 Q14520 HABP2 PTHR24264:SF40 TRYPSIN-RELATED FACTOR VII-ACTIVATING PROTEASE catalytic activity#GO:0003824;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;cellular process#GO:0009987;proteolysis#GO:0006508;metabolic process#GO:0008152;primary metabolic process#GO:0044238 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 serine protease#PC00203;protease#PC00190 HUMAN|HGNC=28125|UniProtKB=Q9BSU3 Q9BSU3 NAA11 PTHR23091:SF282 N-TERMINAL ACETYLTRANSFERASE N-ALPHA-ACETYLTRANSFERASE 11 protein-N-terminal amino-acid acetyltransferase activity#GO:0004596;catalytic activity, acting on a protein#GO:0140096;protein N-acetyltransferase activity#GO:0034212;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein N-acyltransferase activity#GO:0140186;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;N-acetyltransferase activity#GO:0008080 primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;protein acetyltransferase complex#GO:0031248;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;acetyltransferase complex#GO:1902493 acetyltransferase#PC00038 HUMAN|HGNC=18279|UniProtKB=Q9NYH9 Q9NYH9 UTP6 PTHR23271:SF3 HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN 66 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 6 HOMOLOG U3 snoRNA binding#GO:0034511;RNA binding#GO:0003723;nucleic acid binding#GO:0003676;snoRNA binding#GO:0030515;binding#GO:0005488 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;maturation of SSU-rRNA#GO:0030490;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;ribosomal small subunit biogenesis#GO:0042274;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170 intracellular organelle#GO:0043229;preribosome#GO:0030684;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;nucleolus#GO:0005730;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;small-subunit processome#GO:0032040;organelle lumen#GO:0043233;90S preribosome#GO:0030686;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991 RNA metabolism protein#PC00031 HUMAN|HGNC=12226|UniProtKB=A0A0K0K1D8 A0A0K0K1D8 TRBV6-1 PTHR23268:SF107 T-CELL RECEPTOR BETA CHAIN T CELL RECEPTOR BETA VARIABLE 6-1 signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=32264|UniProtKB=P0DV73 P0DV73 FAM90A16 PTHR16035:SF14 PROTEIN FAM90A1 PROTEIN FAM90A10-RELATED HUMAN|HGNC=4315|UniProtKB=Q53GS7 Q53GS7 GLE1 PTHR12960:SF0 GLE-1-RELATED MRNA EXPORT FACTOR GLE1 lipid binding#GO:0008289;protein binding#GO:0005515;small molecule binding#GO:0036094;anion binding#GO:0043168;binding#GO:0005488;ion binding#GO:0043167;alcohol binding#GO:0043178;translation initiation factor binding#GO:0031369;phospholipid binding#GO:0005543 establishment of localization in cell#GO:0051649;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule localization#GO:0033036;nitrogen compound transport#GO:0071705;biosynthetic process#GO:0009058;gene expression#GO:0010467;transport#GO:0006810;metabolic process#GO:0008152;RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907;poly(A)+ mRNA export from nucleus#GO:0016973;macromolecule metabolic process#GO:0043170;establishment of localization#GO:0051234;mRNA transport#GO:0051028;establishment of RNA localization#GO:0051236;nucleobase-containing compound transport#GO:0015931;RNA transport#GO:0050658;RNA localization#GO:0006403;nucleocytoplasmic transport#GO:0006913;nuclear transport#GO:0051169;nuclear export#GO:0051168;localization#GO:0051179;mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;nucleic acid transport#GO:0050657 organelle envelope#GO:0031967;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;nuclear pore#GO:0005643;intracellular anatomical structure#GO:0005622 translation factor#PC00223 HUMAN|HGNC=6929|UniProtKB=Q01726 Q01726 MC1R PTHR22750:SF2 G-PROTEIN COUPLED RECEPTOR MELANOCYTE-STIMULATING HORMONE RECEPTOR signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;molecular transducer activity#GO:0060089;G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888 adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;metabolic process#GO:0008152;secondary metabolite biosynthetic process#GO:0044550;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;phenol-containing compound biosynthetic process#GO:0046189;regulation of signaling#GO:0023051;G protein-coupled receptor signaling pathway#GO:0007186;regulation of intracellular signal transduction#GO:1902531;positive regulation of signaling#GO:0023056;melanin biosynthetic process#GO:0042438;regulation of biological process#GO:0050789;phenol-containing compound metabolic process#GO:0018958;signaling#GO:0023052;response to stimulus#GO:0050896;pigment biosynthetic process#GO:0046148;positive regulation of intracellular signal transduction#GO:1902533;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;regulation of response to stimulus#GO:0048583;secondary metabolic process#GO:0019748;positive regulation of cellular process#GO:0048522;pigment metabolic process#GO:0042440;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;biosynthetic process#GO:0009058;positive regulation of response to stimulus#GO:0048584;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HUMAN|HGNC=20874|UniProtKB=Q8IYI8 Q8IYI8 ZNF440 PTHR24381:SF311 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 440 transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=24702|UniProtKB=Q8IV04 Q8IV04 TBC1D10C PTHR22957:SF324 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN CARABIN GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme activator activity#GO:0008047 vesicle-mediated transport#GO:0016192;cytosolic transport#GO:0016482;retrograde transport, endosome to Golgi#GO:0042147;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;endosomal transport#GO:0016197;intracellular transport#GO:0046907;transport#GO:0006810 GTPase-activating protein#PC00257;protein-binding activity modulator#PC00095;G-protein modulator#PC00022 HUMAN|HGNC=6322|UniProtKB=Q2VIQ3 Q2VIQ3 KIF4B PTHR47969:SF15 CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED ATP-dependent activity#GO:0140657;macromolecular conformation isomerase activity#GO:0120543;polypeptide conformation or assembly isomerase activity#GO:0120544;catalytic activity#GO:0003824;microtubule motor activity#GO:0003777;isomerase activity#GO:0016853;cytoskeletal motor activity#GO:0003774 cellular component organization or biogenesis#GO:0071840;spindle organization#GO:0007051;microtubule-based process#GO:0007017;mitotic cell cycle process#GO:1903047;chromosome segregation#GO:0007059;spindle elongation#GO:0051231;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular process#GO:0009987;microtubule cytoskeleton organization#GO:0000226;mitotic spindle organization#GO:0007052;mitotic cell cycle#GO:0000278;microtubule cytoskeleton organization involved in mitosis#GO:1902850;nuclear chromosome segregation#GO:0098813;cellular component organization#GO:0016043;cell cycle#GO:0007049;cell cycle process#GO:0022402 microtubule cytoskeleton#GO:0015630;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;microtubule binding motor protein#PC00156 HUMAN|HGNC=29801|UniProtKB=Q7L9L4 Q7L9L4 MOB1B PTHR22599:SF63 MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB MOB KINASE ACTIVATOR 1B kinase activator activity#GO:0019209;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;enzyme activator activity#GO:0008047;protein kinase activator activity#GO:0030295;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;protein kinase regulator activity#GO:0019887 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;hippo signaling#GO:0035329;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 kinase activator#PC00138 HUMAN|HGNC=6447|UniProtKB=P35527 P35527 KRT9 PTHR23239:SF96 INTERMEDIATE FILAMENT KERATIN, TYPE I CYTOSKELETAL 9 structural molecule activity#GO:0005198 cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;morphogenesis of an epithelium#GO:0002009;developmental process#GO:0032502;epithelial cell differentiation#GO:0030855;tissue development#GO:0009888;epithelium development#GO:0060429;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular process#GO:0009987;anatomical structure development#GO:0048856;tissue morphogenesis#GO:0048729;supramolecular fiber organization#GO:0097435;animal gross anatomical part developmental process#GO:0160108;intermediate filament-based process#GO:0045103;intermediate filament organization#GO:0045109;cell differentiation#GO:0030154;intermediate filament cytoskeleton organization#GO:0045104;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653 intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;supramolecular fiber#GO:0099512;intermediate filament#GO:0005882;intracellular anatomical structure#GO:0005622;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 intermediate filament#PC00129 HUMAN|HGNC=11995|UniProtKB=O14657 O14657 TOR1B PTHR10760:SF14 TORSIN TORSIN-1B protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;binding#GO:0005488 cellular component organization or biogenesis#GO:0071840;localization#GO:0051179;nucleus organization#GO:0006997;intracellular protein localization#GO:0008104;nuclear envelope organization#GO:0006998;macromolecule localization#GO:0033036;organelle organization#GO:0006996;cellular component organization#GO:0016043;protein localization to nucleus#GO:0034504;cellular process#GO:0009987;nuclear membrane organization#GO:0071763;protein localization to organelle#GO:0033365;membrane organization#GO:0061024;endomembrane system organization#GO:0010256 endoplasmic reticulum lumen#GO:0005788;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;endomembrane system#GO:0012505;nuclear envelope#GO:0005635;cytoplasm#GO:0005737;endoplasmic reticulum#GO:0005783;organelle envelope#GO:0031967;organelle lumen#GO:0043233;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HUMAN|HGNC=25259|UniProtKB=Q8N8A2 Q8N8A2 ANKRD44 PTHR24123:SF82 ANKYRIN REPEAT-CONTAINING SERINE_THREONINE-PROTEIN PHOSPHATASE 6 REGULATORY ANKYRIN REPEAT SUBUNIT B phosphatase regulator activity#GO:0019208;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;protein serine/threonine phosphatase complex#GO:0008287;cytosol#GO:0005829 scaffold/adaptor protein#PC00226 HUMAN|HGNC=31981|UniProtKB=Q5VUR7 Q5VUR7 ANKRD20A3P PTHR24147:SF1 ANKYRIN REPEAT DOMAIN 36-RELATED ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 20A1-RELATED HUMAN|HGNC=41980|UniProtKB=E9PKD4 E9PKD4 NPIPA5 PTHR15438:SF14 NUCLEAR PORE COMPLEX INTERACTING PROTEIN NUCLEAR PORE COMPLEX-INTERACTING PROTEIN FAMILY MEMBER A1-RELATED HUMAN|HGNC=28593|UniProtKB=Q8IXS8 Q8IXS8 HYCC2 PTHR31220:SF3 HYCCIN RELATED HYCCIN 2 cellular localization#GO:0051641;organophosphate biosynthetic process#GO:0090407;localization#GO:0051179;phosphatidylinositol phosphate biosynthetic process#GO:0046854;localization within membrane#GO:0051668;phospholipid biosynthetic process#GO:0008654;glycerolipid metabolic process#GO:0046486;phospholipid metabolic process#GO:0006644;primary metabolic process#GO:0044238;protein localization to plasma membrane#GO:0072659;phosphorus metabolic process#GO:0006793;protein localization to membrane#GO:0072657;intracellular protein localization#GO:0008104;protein localization to cell periphery#GO:1990778;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474;lipid biosynthetic process#GO:0008610;glycerophospholipid metabolic process#GO:0006650;biosynthetic process#GO:0009058;macromolecule localization#GO:0033036;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HUMAN|HGNC=16524|UniProtKB=P61106 P61106 RAB14 PTHR24073:SF185 DRAB5-RELATED RAS-RELATED PROTEIN RAB-14 ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824 vacuole organization#GO:0007033;post-Golgi vesicle-mediated transport#GO:0006892;protein transport#GO:0015031;localization#GO:0051179;cellular localization#GO:0051641;organelle assembly#GO:0070925;cytosolic transport#GO:0016482;endocytosis#GO:0006897;Golgi to endosome transport#GO:0006895;cellular component organization#GO:0016043;intracellular protein localization#GO:0008104;vesicle organization#GO:0016050;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;import into cell#GO:0098657;lytic vacuole organization#GO:0080171;intracellular protein transport#GO:0006886;Golgi vesicle transport#GO:0048193;transport#GO:0006810;phagolysosome assembly#GO:0001845;intracellular transport#GO:0046907;phagocytosis#GO:0006909;cellular component assembly#GO:0022607;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;lysosome organization#GO:0007040;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;macromolecule localization#GO:0033036 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;phagocytic vesicle#GO:0045335;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;early endosome#GO:0005769;endocytic vesicle#GO:0030139;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768 G-protein#PC00020;small GTPase#PC00208 HUMAN|HGNC=4097|UniProtKB=O95257 O95257 GADD45G PTHR10411:SF4 GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 GAMMA molecular sequestering activity#GO:0140313;protein sequestering activity#GO:0140311 regulation of response to stimulus#GO:0048583;regulation of MAPK cascade#GO:0043408;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of MAPK cascade#GO:0043410;regulation of JNK cascade#GO:0046328;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of response to stimulus#GO:0048584;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of JNK cascade#GO:0046330;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of cell cycle#GO:0051726 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 p53 pathway#P00059>GADD45#G01575;p53 pathway#P00059>GADD45#P04626 HUMAN|HGNC=24004|UniProtKB=Q70Z44 Q70Z44 HTR3D PTHR18945:SF409 NEUROTRANSMITTER GATED ION CHANNEL 5-HYDROXYTRYPTAMINE RECEPTOR 3D monoatomic cation channel activity#GO:0005261;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;molecular transducer activity#GO:0060089;channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;signaling receptor activity#GO:0038023;neurotransmitter receptor activity#GO:0030594;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;gated channel activity#GO:0022836;transmembrane signaling receptor activity#GO:0004888 transport#GO:0006810;establishment of localization#GO:0051234;cellular response to nitrogen compound#GO:1901699;synaptic transmission, cholinergic#GO:0007271;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;monoatomic cation transport#GO:0006812;localization#GO:0051179;response to nitrogen compound#GO:1901698;chemical synaptic transmission#GO:0007268;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;metal ion transport#GO:0030001;regulation of membrane potential#GO:0042391;calcium ion transport#GO:0006816;synaptic signaling#GO:0099536;cellular process#GO:0009987;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;response to chemical#GO:0042221;cellular response to chemical stimulus#GO:0070887;response to oxygen-containing compound#GO:1901700;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signaling#GO:0023052 monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane protein complex#GO:0098796;membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;cation channel complex#GO:0034703;signaling receptor complex#GO:0043235 ligand-gated ion channel#PC00141 HUMAN|HGNC=26766|UniProtKB=Q8N957 Q8N957 ANKFN1 PTHR21437:SF3 WIDE AWAKE ANKYRIN REPEAT AND FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN 1 mitotic cell cycle process#GO:1903047;microtubule-based process#GO:0007017;establishment of spindle orientation#GO:0051294;cellular component organization or biogenesis#GO:0071840;establishment of mitotic spindle orientation#GO:0000132;establishment of localization#GO:0051234;establishment of localization in cell#GO:0051649;establishment of spindle localization#GO:0051293;cellular process#GO:0009987;organelle organization#GO:0006996;establishment of mitotic spindle localization#GO:0040001;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;regulation of establishment or maintenance of cell polarity#GO:0032878;establishment or maintenance of cell polarity#GO:0007163;organelle localization#GO:0051640;localization#GO:0051179;cellular localization#GO:0051641;spindle localization#GO:0051653;microtubule cytoskeleton organization#GO:0000226;establishment of cell polarity#GO:0030010;regulation of biological process#GO:0050789;cell cycle process#GO:0022402;cell cycle#GO:0007049;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cellular component organization#GO:0016043;mitotic cell cycle#GO:0000278;regulation of cellular process#GO:0050794;establishment of organelle localization#GO:0051656 microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;spindle#GO:0005819;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 HUMAN|HGNC=8482|UniProtKB=Q9GZM6 Q9GZM6 OR8D2 PTHR48018:SF173 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 8D2 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 G protein-coupled receptor signaling pathway#GO:0007186;nervous system process#GO:0050877;sensory perception#GO:0007600;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;sensory perception of smell#GO:0007608;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;cellular process#GO:0009987;signal transduction#GO:0007165;multicellular organismal process#GO:0032501;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=17089|UniProtKB=Q8NF91 Q8NF91 SYNE1 PTHR14514:SF3 PKA ANCHORING PROTEIN NESPRIN-1 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;protein-membrane adaptor activity#GO:0043495 regulation of cell projection assembly#GO:0060491;localization#GO:0051179;cellular localization#GO:0051641;organelle localization#GO:0051640;centrosome localization#GO:0051642;regulation of cellular component biogenesis#GO:0044087;regulation of plasma membrane bounded cell projection assembly#GO:0120032;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;establishment of organelle localization#GO:0051656;regulation of biological process#GO:0050789;nuclear migration#GO:0007097;regulation of organelle organization#GO:0033043;regulation of plasma membrane bounded cell projection organization#GO:0120035;establishment of localization#GO:0051234;transport#GO:0006810;regulation of cell projection organization#GO:0031344;regulation of cilium assembly#GO:1902017;intracellular transport#GO:0046907;biological regulation#GO:0065007;establishment of localization in cell#GO:0051649;regulation of organelle assembly#GO:1902115;cellular process#GO:0009987 endoplasmic reticulum#GO:0005783;membraneless organelle#GO:0043228;sarcomere#GO:0030017;organelle membrane#GO:0031090;nuclear membrane#GO:0031965;membrane#GO:0016020;nucleus#GO:0005634;contractile muscle fiber#GO:0043292;sarcoplasmic reticulum#GO:0016529;supramolecular polymer#GO:0099081;endomembrane system#GO:0012505;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;nuclear envelope#GO:0005635;sarcoplasm#GO:0016528;intracellular organelle#GO:0043229;myofibril#GO:0030016;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membrane-bounded organelle#GO:0043227;organelle envelope#GO:0031967;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 HUMAN|Gene=TPT1L_HUMAN|UniProtKB=Q56UQ5 Q56UQ5 PTHR11991:SF9 TRANSLATIONALLY CONTROLLED TUMOR PROTEIN-RELATED TPT1-LIKE PROTEIN-RELATED metal ion binding#GO:0046872;cation binding#GO:0043169;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;calcium ion binding#GO:0005509 negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of response to stimulus#GO:0048585;negative regulation of apoptotic process#GO:0043066;negative regulation of programmed cell death#GO:0043069;regulation of metabolic process#GO:0019222;regulation of catabolic process#GO:0009894;negative regulation of autophagy#GO:0010507;regulation of response to stimulus#GO:0048583;regulation of apoptotic process#GO:0042981;negative regulation of cellular process#GO:0048523;regulation of cell communication#GO:0010646;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of programmed cell death#GO:0043067;regulation of autophagy#GO:0010506;negative regulation of biological process#GO:0048519;negative regulation of cell communication#GO:0010648;negative regulation of catabolic process#GO:0009895;regulation of apoptotic signaling pathway#GO:2001233;regulation of signaling#GO:0023051;negative regulation of apoptotic signaling pathway#GO:2001234;negative regulation of signaling#GO:0023057 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 microtubule or microtubule-binding cytoskeletal protein#PC00157;cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HUMAN|HGNC=16977|UniProtKB=Q9UBK5 Q9UBK5 HCST PTHR21409:SF1 HEMATOPOIETIC CELL SIGNAL TRANSDUCER HEMATOPOIETIC CELL SIGNAL TRANSDUCER molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;regulation of cell communication#GO:0010646;positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051897;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051896;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HUMAN|HGNC=1753|UniProtKB=P55290 P55290 CDH13 PTHR24027:SF80 CADHERIN-23 CADHERIN-13 protein binding#GO:0005515;beta-catenin binding#GO:0008013;binding#GO:0005488;cell adhesion molecule binding#GO:0050839 cellular process#GO:0009987;cell adhesion#GO:0007155;cell-cell adhesion#GO:0098609;cell motility#GO:0048870;cell migration#GO:0016477 extrinsic component of plasma membrane#GO:0019897;extrinsic component of membrane#GO:0019898;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 cadherin#PC00057;cell adhesion molecule#PC00069 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HUMAN|HGNC=26515|UniProtKB=Q96MF6 Q96MF6 COQ10A PTHR12901:SF8 SPERM PROTEIN HOMOLOG COENZYME Q-BINDING PROTEIN COQ10 HOMOLOG A, MITOCHONDRIAL intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HUMAN|HGNC=69|UniProtKB=P61221 P61221 ABCE1 PTHR19248:SF32 ATP-BINDING TRANSPORT PROTEIN-RELATED ATP-BINDING CASSETTE SUB-FAMILY E MEMBER 1 nucleotide binding#GO:0000166;transition metal ion binding#GO:0046914;ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;cation binding#GO:0043169;ribonucleoprotein complex binding#GO:0043021;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;iron ion binding#GO:0005506;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;ATP binding#GO:0005524;ribosome binding#GO:0043022;protein-containing complex binding#GO:0044877;metal ion binding#GO:0046872 biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein-containing complex organization#GO:0043933;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;protein-containing complex disassembly#GO:0032984;protein biosynthetic process#GO:0160307;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;cellular component disassembly#GO:0022411;translation#GO:0006412;translational initiation#GO:0006413;translational termination#GO:0006415 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 HUMAN|HGNC=1116|UniProtKB=P35613 P35613 BSG PTHR10075:SF107 BASIGIN RELATED BASIGIN cell adhesion molecule#PC00069 HUMAN|HGNC=21721|UniProtKB=Q96EH3 Q96EH3 MALSU1 PTHR21043:SF0 IOJAP SUPERFAMILY ORTHOLOG MITOCHONDRIAL ASSEMBLY OF RIBOSOMAL LARGE SUBUNIT PROTEIN 1 binding#GO:0005488;protein-containing complex binding#GO:0044877;ribosome binding#GO:0043022;ribonucleoprotein complex binding#GO:0043021;ribosomal large subunit binding#GO:0043023 protein-containing complex assembly#GO:0065003;mitochondrial large ribosomal subunit assembly#GO:1902775;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;ribonucleoprotein complex biogenesis#GO:0022613;ribosome assembly#GO:0042255;ribosomal large subunit biogenesis#GO:0042273;organelle assembly#GO:0070925;ribosome biogenesis#GO:0042254;protein-RNA complex assembly#GO:0022618;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;ribosomal large subunit assembly#GO:0000027;cellular component assembly#GO:0022607;protein-containing complex organization#GO:0043933;mitochondrial ribosome assembly#GO:0061668;cellular component organization or biogenesis#GO:0071840;protein-RNA complex organization#GO:0071826 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739 HUMAN|HGNC=26032|UniProtKB=Q7L5N7 Q7L5N7 LPCAT2 PTHR23063:SF21 PHOSPHOLIPID ACYLTRANSFERASE LYSOPHOSPHATIDYLCHOLINE ACYLTRANSFERASE 2 acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 metabolite interconversion enzyme#PC00262;transferase#PC00220;acyltransferase#PC00042 HUMAN|HGNC=8296|UniProtKB=P0C645 P0C645 OR4E1 PTHR26451:SF233 G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN OLFACTORY RECEPTOR 4E1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;binding#GO:0005488 detection of chemical stimulus#GO:0009593;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;response to stimulus#GO:0050896;response to chemical#GO:0042221;nervous system process#GO:0050877;sensory perception#GO:0007600;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008 membrane#GO:0016020;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021 HUMAN|HGNC=8988|UniProtKB=Q13526 Q13526 PIN1 PTHR10657:SF31 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE NIMA-INTERACTING 1 catalytic activity, acting on a protein#GO:0140096;cis-trans isomerase activity#GO:0016859;peptidyl-prolyl cis-trans isomerase activity#GO:0003755;isomerase activity#GO:0016853;catalytic activity#GO:0003824 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cytosol#GO:0005829;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 chaperone#PC00072 HUMAN|HGNC=26663|UniProtKB=Q8NA66 Q8NA66 CNBD1 PTHR23011:SF32 CYCLIC NUCLEOTIDE-BINDING DOMAIN CONTAINING PROTEIN CYCLIC NUCLEOTIDE-BINDING DOMAIN-CONTAINING PROTEIN 1 HUMAN|HGNC=18801|UniProtKB=Q7Z3K3 Q7Z3K3 POGZ PTHR24403:SF59 ZINC FINGER PROTEIN POGO TRANSPOSABLE ELEMENT WITH ZNF DOMAIN DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HUMAN|HGNC=31991|UniProtKB=P0DPF3 P0DPF3 NBPF9 PTHR14199:SF35 NEUROBLASTOMA BREAKPOINT FAMILY MEMBER 6-LIKE PROTEIN NBPF FAMILY MEMBER NBPF1-RELATED HUMAN|HGNC=8491|UniProtKB=O43913 O43913 ORC5 PTHR12705:SF0 ORIGIN RECOGNITION COMPLEX SUBUNIT 5 ORIGIN RECOGNITION COMPLEX SUBUNIT 5 nucleic acid binding#GO:0003676;binding#GO:0005488;DNA replication origin binding#GO:0003688;sequence-specific double-stranded DNA binding#GO:1990837;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;sequence-specific DNA binding#GO:0043565 DNA replication initiation#GO:0006270;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;macromolecule metabolic process#GO:0043170;DNA-templated DNA replication#GO:0006261;DNA replication#GO:0006260;cellular process#GO:0009987;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound metabolic process#GO:0006139 membraneless organelle#GO:0043228;origin recognition complex#GO:0000808;nuclear protein-containing complex#GO:0140513;nuclear origin of replication recognition complex#GO:0005664;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;organelle lumen#GO:0043233;chromosome#GO:0005694 replication origin binding protein#PC00199 HUMAN|HGNC=20194|UniProtKB=O15160 O15160 POLR1C PTHR11800:SF13 DNA-DIRECTED RNA POLYMERASE DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1 transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a nucleic acid#GO:0140640;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on RNA#GO:0140098 intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;transferase complex, transferring phosphorus-containing groups#GO:0061695;RNA polymerase III complex#GO:0005666;RNA polymerase I complex#GO:0005736;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;organelle lumen#GO:0043233;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;intracellular protein-containing complex#GO:0140535;membrane-enclosed lumen#GO:0031974;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232 DNA-directed RNA polymerase#PC00019 HUMAN|HGNC=9288|UniProtKB=P41236 P41236 PPP1R2 PTHR12398:SF35 PROTEIN PHOSPHATASE INHIBITOR PROTEIN PHOSPHATASE INHIBITOR 2-RELATED enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;protein phosphatase regulator activity#GO:0019888;protein phosphatase inhibitor activity#GO:0004864;enzyme inhibitor activity#GO:0004857;phosphatase regulator activity#GO:0019208;phosphatase inhibitor activity#GO:0019212;molecular function regulator activity#GO:0098772 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 phosphatase inhibitor#PC00183 HUMAN|HGNC=4135|UniProtKB=P07902 P07902 GALT PTHR11943:SF1 GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE transferase activity, transferring phosphorus-containing groups#GO:0016772;nucleotidyltransferase activity#GO:0016779;transferase activity#GO:0016740;catalytic activity#GO:0003824 organophosphate metabolic process#GO:0019637;phosphorus metabolic process#GO:0006793;hexose metabolic process#GO:0019318;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;carbohydrate metabolic process#GO:0005975;small molecule catabolic process#GO:0044282;metabolic process#GO:0008152;monosaccharide metabolic process#GO:0005996;carbohydrate catabolic process#GO:0016052 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 nucleotidyltransferase#PC00174 Interleukin signaling pathway#P00036>Receptor subunit alpha#P00992;Fructose galactose metabolism#P02744>Hexose 1-P uridyltransferase#P02964 HUMAN|HGNC=1749|UniProtKB=Q9Y6N8 Q9Y6N8 CDH10 PTHR24027:SF290 CADHERIN-23 CADHERIN-10 protein binding#GO:0005515;beta-catenin binding#GO:0008013;binding#GO:0005488;cell adhesion molecule binding#GO:0050839 cell migration#GO:0016477;cellular component assembly#GO:0022607;cell-cell adhesion#GO:0098609;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;cell-cell junction assembly#GO:0007043;cell-cell junction organization#GO:0045216;developmental process#GO:0032502;cell morphogenesis#GO:0000902;cell motility#GO:0048870;cell junction organization#GO:0034330;cellular component organization#GO:0016043;cell junction assembly#GO:0034329;adherens junction organization#GO:0034332;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;synaptic membrane adhesion#GO:0099560;cell adhesion#GO:0007155;synapse organization#GO:0050808 membrane protein complex#GO:0098796;cell-cell junction#GO:0005911;membrane#GO:0016020;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;extrinsic component of membrane#GO:0019898;cell junction#GO:0030054;extrinsic component of plasma membrane#GO:0019897;adherens junction#GO:0005912;anchoring junction#GO:0070161 cell adhesion molecule#PC00069;cadherin#PC00057 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HUMAN|HGNC=20821|UniProtKB=Q17RW2 Q17RW2 COL24A1 PTHR24023:SF987 COLLAGEN ALPHA COLLAGEN ALPHA-1(XXIV) CHAIN structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 extracellular structure organization#GO:0043062;cellular component organization#GO:0016043;cellular process#GO:0009987;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;external encapsulating structure organization#GO:0045229 basement membrane#GO:0005604;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cellular anatomical structure#GO:0110165 extracellular matrix structural protein#PC00103;extracellular matrix protein#PC00102 HUMAN|HGNC=12033|UniProtKB=Q13114 Q13114 TRAF3 PTHR10131:SF76 TNF RECEPTOR ASSOCIATED FACTOR TNF RECEPTOR-ASSOCIATED FACTOR 3 signaling adaptor activity#GO:0035591;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cell communication#GO:0010646;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;cell communication#GO:0007154;regulation of canonical NF-kappaB signal transduction#GO:0043122;cellular process#GO:0009987;signal transduction#GO:0007165;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;cell surface receptor signaling pathway#GO:0007166;regulation of response to stimulus#GO:0048583 membrane#GO:0016020;cytoplasmic side of plasma membrane#GO:0009898;cell periphery#GO:0071944;cytoplasmic side of membrane#GO:0098562;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HUMAN|HGNC=26016|UniProtKB=Q9H400 Q9H400 LIME1 PTHR47740:SF1 LCK-INTERACTING TRANSMEMBRANE ADAPTER 1, LIME1 LCK-INTERACTING TRANSMEMBRANE ADAPTER 1 protein kinase binding#GO:0019901;enzyme binding#GO:0019899;kinase binding#GO:0019900;binding#GO:0005488;protein binding#GO:0005515 regulation of immune response#GO:0050776;immune system process#GO:0002376;cell communication#GO:0007154;immune response-regulating signaling pathway#GO:0002764;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;immune response-activating cell surface receptor signaling pathway#GO:0002429;signaling#GO:0023052;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;response to stimulus#GO:0050896;cell surface receptor signaling pathway#GO:0007166;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;immune response-activating signaling pathway#GO:0002757;B cell receptor signaling pathway#GO:0050853;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;activation of immune response#GO:0002253;positive regulation of immune system process#GO:0002684;immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007;antigen receptor-mediated signaling pathway#GO:0050851;positive regulation of response to stimulus#GO:0048584 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane protein complex#GO:0098796;membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;signaling receptor complex#GO:0043235 scaffold/adaptor protein#PC00226 HUMAN|HGNC=851|UniProtKB=P38606 P38606 ATP6V1A PTHR43607:SF9 V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A monoatomic ion transmembrane transporter activity#GO:0015075;primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804;proton transmembrane transporter activity#GO:0015078;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic cation transmembrane transporter activity#GO:0008324;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829 monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;proton transmembrane transport#GO:1902600;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987 vacuolar proton-transporting V-type ATPase complex#GO:0016471;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ATPase complex#GO:1904949;transmembrane transporter complex#GO:1902495;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ATPase dependent transmembrane transport complex#GO:0098533;membrane protein complex#GO:0098796;lytic vacuole membrane#GO:0098852;lysosome#GO:0005764;cation-transporting ATPase complex#GO:0090533;organelle#GO:0043226;vacuolar proton-transporting V-type ATPase, V1 domain#GO:0000221;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;proton-transporting two-sector ATPase complex#GO:0016469;lytic vacuole#GO:0000323;transporter complex#GO:1990351;vacuolar membrane#GO:0005774;proton-transporting V-type ATPase complex#GO:0033176;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane#GO:0016020;lysosomal membrane#GO:0005765;protein-containing complex#GO:0032991;vacuole#GO:0005773;cytoplasm#GO:0005737 ATP synthase#PC00002 HUMAN|HGNC=3583|UniProtKB=Q8NB91 Q8NB91 FANCB PTHR28450:SF1 FANCONI ANEMIA GROUP B PROTEIN FANCONI ANEMIA GROUP B PROTEIN cellular process#GO:0009987;positive regulation of biological process#GO:0048518;response to stress#GO:0006950;positive regulation of macromolecule metabolic process#GO:0010604;negative regulation of double-strand break repair via homologous recombination#GO:2000042;DNA recombination#GO:0006310;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;double-strand break repair#GO:0006302;double-strand break repair via homologous recombination#GO:0000724;regulation of DNA metabolic process#GO:0051052;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of double-strand break repair via homologous recombination#GO:0010569;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;regulation of DNA recombination#GO:0000018;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of cellular response to stress#GO:0080135;positive regulation of metabolic process#GO:0009893;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;replication-born double-strand break repair via sister chromatid exchange#GO:1990414;regulation of primary metabolic process#GO:0080090;positive regulation of DNA repair#GO:0045739;negative regulation of DNA metabolic process#GO:0051053;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of response to stimulus#GO:0048585;positive regulation of response to stimulus#GO:0048584;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of response to stimulus#GO:0048583;regulation of DNA repair#GO:0006282;DNA damage response#GO:0006974;regulation of response to stress#GO:0080134;negative regulation of cellular process#GO:0048523;DNA repair#GO:0006281;macromolecule metabolic process#GO:0043170;cellular response to stimulus#GO:0051716;negative regulation of DNA recombination#GO:0045910;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;positive regulation of DNA metabolic process#GO:0051054;positive regulation of double-strand break repair#GO:2000781;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;recombinational repair#GO:0000725;regulation of double-strand break repair#GO:2000779 Fanconi anaemia nuclear complex#GO:0043240;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=21167|UniProtKB=Q76G19 Q76G19 PDZD4 PTHR15545:SF4 PDZ DOMAIN CONTAINING RING FINGER PROTEIN 3, 4 PDZ DOMAIN-CONTAINING PROTEIN 4 HUMAN|HGNC=23802|UniProtKB=Q6T310 Q6T310 RASL11A PTHR45704:SF3 RAS-LIKE FAMILY MEMBER 11 RAS-LIKE PROTEIN FAMILY MEMBER 11A HUMAN|HGNC=33753|UniProtKB=Q2T9L4 Q2T9L4 INSYN1 PTHR15917:SF3 FAMILY NOT NAMED INHIBITORY SYNAPTIC FACTOR 1 regulation of biological quality#GO:0065008;cell communication#GO:0007154;nervous system process#GO:0050877;trans-synaptic signaling#GO:0099537;signaling#GO:0023052;chemical synaptic transmission, postsynaptic#GO:0099565;response to stimulus#GO:0050896;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;regulation of postsynaptic membrane potential#GO:0060078;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;chemical synaptic transmission#GO:0007268;system process#GO:0003008;regulation of membrane potential#GO:0042391;cell surface receptor signaling pathway#GO:0007166;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;signal transduction#GO:0007165;cellular process#GO:0009987;synaptic signaling#GO:0099536 postsynapse#GO:0098794;neuron to neuron synapse#GO:0098984;cellular anatomical structure#GO:0110165;synapse#GO:0045202;postsynaptic specialization#GO:0099572;organelle#GO:0043226;asymmetric synapse#GO:0032279;postsynaptic density#GO:0014069;cell junction#GO:0030054 HUMAN|HGNC=2046|UniProtKB=O14493 O14493 CLDN4 PTHR12002:SF89 CLAUDIN CLAUDIN-4 localization#GO:0051179;cell junction organization#GO:0034330;cell junction assembly#GO:0034329;cellular component organization#GO:0016043;cellular component organization or biogenesis#GO:0071840;paracellular transport#GO:0160184;renal absorption#GO:0070293;establishment of localization#GO:0051234;system process#GO:0003008;cell-cell junction organization#GO:0045216;cell-cell junction assembly#GO:0007043;transport#GO:0006810;cellular component assembly#GO:0022607;multicellular organismal process#GO:0032501;cellular component biogenesis#GO:0044085;renal system process#GO:0003014;cellular process#GO:0009987 apical junction complex#GO:0043296;cell junction#GO:0030054;tight junction#GO:0070160;anchoring junction#GO:0070161;membrane#GO:0016020;cell-cell junction#GO:0005911;cell periphery#GO:0071944;bicellular tight junction#GO:0005923;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cell junction protein#PC00070;tight junction#PC00214 HUMAN|HGNC=16953|UniProtKB=Q15063 Q15063 POSTN PTHR10900:SF12 PERIOSTIN-RELATED PERIOSTIN binding#GO:0005488;cell adhesion molecule binding#GO:0050839;protein binding#GO:0005515 homophilic cell-cell adhesion#GO:0007156;cellular component organization#GO:0016043;cell-cell adhesion#GO:0098609;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;external encapsulating structure organization#GO:0045229;extracellular structure organization#GO:0043062;cell adhesion#GO:0007155 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 cell adhesion molecule#PC00069 HUMAN|HGNC=4502|UniProtKB=Q9Y5Y4 Q9Y5Y4 PTGDR2 PTHR24229:SF8 NEUROPEPTIDES RECEPTOR PROSTAGLANDIN D2 RECEPTOR 2 transmembrane signaling receptor activity#GO:0004888;neuropeptide binding#GO:0042923;peptide binding#GO:0042277;binding#GO:0005488;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;neuropeptide signaling pathway#GO:0007218;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005 G-protein coupled receptor#PC00021 HUMAN|HGNC=9001|UniProtKB=Q00169 Q00169 PITPNA PTHR10658:SF28 PHOSPHATIDYLINOSITOL TRANSFER PROTEIN PHOSPHATIDYLINOSITOL TRANSFER PROTEIN ALPHA ISOFORM ion binding#GO:0043167;phosphatidylcholine intramembrane carrier activity#GO:0008525;lipid carrier activity#GO:0005319;small molecule binding#GO:0036094;anion binding#GO:0043168;cation binding#GO:0043169;intramembrane lipid carrier activity#GO:0140303;phosphatidylinositol binding#GO:0035091;phospholipid binding#GO:0005543;phosphatidylinositol transfer activity#GO:0008526;phosphatidylcholine binding#GO:0031210;molecular carrier activity#GO:0140104;binding#GO:0005488;lipid transfer activity#GO:0120013;lipid binding#GO:0008289;transporter activity#GO:0005215 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 transporter#PC00227 HUMAN|HGNC=9349|UniProtKB=Q9NQX1 Q9NQX1 PRDM5 PTHR16515:SF32 PR DOMAIN ZINC FINGER PROTEIN PR DOMAIN ZINC FINGER PROTEIN 5 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676 negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=11209|UniProtKB=Q02446 Q02446 SP4 PTHR23235:SF17 KRUEPPEL-LIKE TRANSCRIPTION FACTOR TRANSCRIPTION FACTOR SP4 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=11536|UniProtKB=Q6P1X5 Q6P1X5 TAF2 PTHR15137:SF9 TRANSCRIPTION INITIATION FACTOR TFIID TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2 double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;chromatin binding#GO:0003682;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;DNA-templated transcription initiation#GO:0006352;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;transcription by RNA polymerase II#GO:0006366;macromolecule metabolic process#GO:0043170;transcription initiation at RNA polymerase II promoter#GO:0006367;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139 nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;transcription regulator complex#GO:0005667;transferase complex#GO:1990234;protein-containing complex#GO:0032991;transcription factor TFIID complex#GO:0005669;RNA polymerase II transcription regulator complex#GO:0090575;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;RNA polymerase II, holoenzyme#GO:0016591;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029 RNA metabolism protein#PC00031;general transcription factor#PC00259 General transcription regulation#P00023>TBP-associated factors#P00658;Transcription regulation by bZIP transcription factor#P00055>TBP-associated factors#P01385 HUMAN|HGNC=12021|UniProtKB=O60704 O60704 TPST2 PTHR12788:SF6 PROTEIN-TYROSINE SULFOTRANSFERASE 2 PROTEIN-TYROSINE SULFOTRANSFERASE 2 catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring sulphur-containing groups#GO:0016782;sulfotransferase activity#GO:0008146 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 transferase#PC00220 HUMAN|HGNC=9570|UniProtKB=P61289 P61289 PSME3 PTHR10660:SF4 PROTEASOME REGULATOR PA28 PROTEASOME ACTIVATOR COMPLEX SUBUNIT 3 peptidase regulator activity#GO:0061134;peptidase activator activity#GO:0016504;enzyme activator activity#GO:0008047;endopeptidase regulator activity#GO:0061135;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234 regulation of mitotic cell cycle#GO:0007346;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of cell cycle process#GO:0010564;biological regulation#GO:0065007;regulation of proteasomal protein catabolic process#GO:0061136;regulation of catabolic process#GO:0009894;regulation of biological process#GO:0050789;regulation of cell cycle phase transition#GO:1901987;regulation of cell cycle G1/S phase transition#GO:1902806;regulation of cell cycle#GO:0051726;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of G1/S transition of mitotic cell cycle#GO:2000045;regulation of protein catabolic process#GO:0042176;regulation of mitotic cell cycle phase transition#GO:1901990 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233 Cell cycle#P00013>Proteasome#P00480 HUMAN|HGNC=9827|UniProtKB=Q99638 Q99638 RAD9A PTHR15237:SF1 DNA REPAIR PROTEIN RAD9 CELL CYCLE CHECKPOINT CONTROL PROTEIN RAD9A DNA replication checkpoint signaling#GO:0000076;negative regulation of cell cycle#GO:0045786;cellular response to abiotic stimulus#GO:0071214;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;regulation of cell cycle process#GO:0010564;cell cycle checkpoint signaling#GO:0000075;signal transduction#GO:0007165;cellular process#GO:0009987;response to stress#GO:0006950;negative regulation of mitotic cell cycle#GO:0045930;mitotic intra-S DNA damage checkpoint signaling#GO:0031573;cellular response to stress#GO:0033554;cellular response to radiation#GO:0071478;signaling#GO:0023052;regulation of cell cycle#GO:0051726;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;signal transduction in response to DNA damage#GO:0042770;response to ionizing radiation#GO:0010212;cell cycle process#GO:0022402;negative regulation of biological process#GO:0048519;response to abiotic stimulus#GO:0009628;negative regulation of cell cycle phase transition#GO:1901988;mitotic cell cycle process#GO:1903047;macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;negative regulation of cell cycle process#GO:0010948;DNA repair#GO:0006281;negative regulation of cellular process#GO:0048523;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;DNA damage checkpoint signaling#GO:0000077;regulation of mitotic cell cycle#GO:0007346;response to radiation#GO:0009314;mitotic DNA integrity checkpoint signaling#GO:0044774;DNA integrity checkpoint signaling#GO:0031570;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;mitotic cell cycle#GO:0000278;cellular response to environmental stimulus#GO:0104004;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;mitotic DNA damage checkpoint signaling#GO:0044773;regulation of cell cycle phase transition#GO:1901987;mitotic cell cycle checkpoint signaling#GO:0007093;cell cycle#GO:0007049;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 condensed chromosome#GO:0000793;nuclear protein-containing complex#GO:0140513;condensed nuclear chromosome#GO:0000794;membraneless organelle#GO:0043228;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;chromosome#GO:0005694;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231 exodeoxyribonuclease#PC00098 HUMAN|HGNC=16842|UniProtKB=O14683 O14683 TP53I11 PTHR31584:SF1 TUMOR PROTEIN P53-INDUCIBLE PROTEIN 11 TUMOR PROTEIN P53-INDUCIBLE PROTEIN 11 HUMAN|HGNC=3241|UniProtKB=Q05215 Q05215 EGR4 PTHR23235:SF58 KRUEPPEL-LIKE TRANSCRIPTION FACTOR EARLY GROWTH RESPONSE PROTEIN 4 binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=9159|UniProtKB=Q9UL42 Q9UL42 PNMA2 PTHR23095:SF16 PARANEOPLASTIC ANTIGEN PARANEOPLASTIC ANTIGEN MA2 transcription cofactor#PC00217 HUMAN|HGNC=8016|UniProtKB=P46459 P46459 NSF PTHR23078:SF3 VESICULAR-FUSION PROTEIN NSF VESICLE-FUSING ATPASE ATP-dependent activity#GO:0140657;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP hydrolysis activity#GO:0016887;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111 Golgi to plasma membrane protein transport#GO:0043001;Golgi to plasma membrane transport#GO:0006893;intra-Golgi vesicle-mediated transport#GO:0006891;protein localization to plasma membrane#GO:0072659;protein localization to membrane#GO:0072657;protein transport#GO:0015031;post-Golgi vesicle-mediated transport#GO:0006892;cellular localization#GO:0051641;localization#GO:0051179;localization within membrane#GO:0051668;establishment of protein localization to plasma membrane#GO:0061951;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of protein localization#GO:0045184;macromolecule localization#GO:0033036;establishment of protein localization to membrane#GO:0090150;vesicle-mediated transport to the plasma membrane#GO:0098876;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;Golgi vesicle transport#GO:0048193;transport#GO:0006810;protein localization to cell periphery#GO:1990778 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;Golgi stack#GO:0005795;Golgi apparatus subcompartment#GO:0098791;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794 membrane traffic protein#PC00150 Synaptic vesicle trafficking#P05734>NSF#P05774;Ionotropic glutamate receptor pathway#P00037>NSF#P01020 HUMAN|HGNC=16504|UniProtKB=Q8NFQ5 Q8NFQ5 BPIFB6 PTHR46019:SF2 BPI FOLD-CONTAINING FAMILY B MEMBER 4-RELATED BPI FOLD-CONTAINING FAMILY B MEMBER 6 HUMAN|HGNC=18514|UniProtKB=Q8N0X7 Q8N0X7 SPART PTHR21068:SF55 SPARTIN SPARTIN negative regulation of cell communication#GO:0010648;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;cell division#GO:0051301;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092;negative regulation of BMP signaling pathway#GO:0030514;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;regulation of cellular response to growth factor stimulus#GO:0090287;biological regulation#GO:0065007;negative regulation of response to stimulus#GO:0048585;cellular process#GO:0009987;regulation of BMP signaling pathway#GO:0030510 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=15887|UniProtKB=Q9BX40 Q9BX40 LSM14B PTHR13586:SF1 SCD6 PROTEIN-RELATED PROTEIN LSM14 HOMOLOG B mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 cellular component organization or biogenesis#GO:0071840;organelle assembly#GO:0070925;cytoplasmic stress granule assembly#GO:0034063;cellular component assembly#GO:0022607;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;P-body assembly#GO:0033962;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;ribonucleoprotein granule#GO:0035770;organelle#GO:0043226;supramolecular complex#GO:0099080;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;P-body#GO:0000932 RNA metabolism protein#PC00031 HUMAN|HGNC=9673|UniProtKB=Q12913 Q12913 PTPRJ PTHR19134:SF554 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE ETA phosphoprotein phosphatase activity#GO:0004721;protein tyrosine phosphatase activity#GO:0004725;hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578 regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;anatomical structure development#GO:0048856;cell communication#GO:0007154;system development#GO:0048731;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;axon development#GO:0061564;axon guidance#GO:0007411;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;neuron projection guidance#GO:0097485;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;response to stimulus#GO:0050896;cell differentiation#GO:0030154;cell development#GO:0048468;signaling#GO:0023052;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;neuron development#GO:0048666;axonogenesis#GO:0007409;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;neuron projection development#GO:0031175;cellular process#GO:0009987;signal transduction#GO:0007165;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cell projection morphogenesis#GO:0048858;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182 protein modifying enzyme#PC00260;protein phosphatase#PC00195 HUMAN|HGNC=24686|UniProtKB=Q8WUP2 Q8WUP2 FBLIM1 PTHR24207:SF1 ZYX102 PROTEIN FILAMIN-BINDING LIM PROTEIN 1 binding#GO:0005488;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515 cell-cell adhesion#GO:0098609;cell adhesion#GO:0007155;cellular process#GO:0009987 focal adhesion#GO:0005925;cell-substrate junction#GO:0030055;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165;actomyosin#GO:0042641;actin cytoskeleton#GO:0015629;anchoring junction#GO:0070161;intracellular anatomical structure#GO:0005622;cell junction#GO:0030054;membraneless organelle#GO:0043228;actin filament bundle#GO:0032432;intracellular organelle#GO:0043229;stress fiber#GO:0001725;cytoskeleton#GO:0005856 kinase modulator#PC00140 HUMAN|HGNC=19600|UniProtKB=Q9H340 Q9H340 OR51B6 PTHR26450:SF22 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 51B6 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=8868|UniProtKB=Q9NQP4 Q9NQP4 PFDN4 PTHR21100:SF9 PREFOLDIN SUBUNIT 4 PREFOLDIN SUBUNIT 4 metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein folding#GO:0006457;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 HUMAN|HGNC=3702|UniProtKB=Q13642 Q13642 FHL1 PTHR47029:SF3 FOUR AND A HALF LIM DOMAINS PROTEIN 1 FOUR AND A HALF LIM DOMAINS PROTEIN 1 transmembrane transporter binding#GO:0044325;binding#GO:0005488;protein binding#GO:0005515 HUMAN|HGNC=17956|UniProtKB=Q9BV38 Q9BV38 WDR18 PTHR18763:SF0 WD-REPEAT PROTEIN 18 WD REPEAT-CONTAINING PROTEIN 18 cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;RNA metabolic process#GO:0016070;DNA-templated DNA replication#GO:0006261;rRNA processing#GO:0006364;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;DNA replication#GO:0006260 organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;protein-DNA complex#GO:0032993;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;pre-replicative complex#GO:0036387;intracellular organelle lumen#GO:0070013;endoribonuclease complex#GO:1902555;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;nuclear pre-replicative complex#GO:0005656;membrane-enclosed lumen#GO:0031974;protein-containing complex#GO:0032991;endonuclease complex#GO:1905348;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513 HUMAN|HGNC=25141|UniProtKB=Q96GE4 Q96GE4 CEP95 PTHR22545:SF0 CENTROSOMAL PROTEIN OF 95 KDA CENTROSOMAL PROTEIN OF 95 KDA intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165;spindle pole#GO:0000922;microtubule cytoskeleton#GO:0015630;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;spindle#GO:0005819;cytoskeleton#GO:0005856 HUMAN|HGNC=6816|UniProtKB=P20794 P20794 MAK PTHR24055:SF194 MITOGEN-ACTIVATED PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE MAK protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096 establishment of localization#GO:0051234;transport along microtubule#GO:0010970;transport#GO:0006810;intracellular transport#GO:0046907;plasma membrane bounded cell projection assembly#GO:0120031;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;cytoskeleton-dependent intracellular transport#GO:0030705;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;localization#GO:0051179;organelle assembly#GO:0070925;intraciliary transport#GO:0042073;microtubule-based movement#GO:0007018;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular process#GO:0009987;cell projection assembly#GO:0030031;signal transduction#GO:0007165;establishment of localization in cell#GO:0051649;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cilium organization#GO:0044782;cellular localization#GO:0051641;microtubule-based transport#GO:0099111;signaling#GO:0023052;response to stimulus#GO:0050896;cell projection organization#GO:0030030;regulation of biological process#GO:0050789;cilium assembly#GO:0060271;cellular component organization#GO:0016043 cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cilium#GO:0005929;intracellular organelle#GO:0043229 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=17148|UniProtKB=Q53HV7 Q53HV7 SMUG1 PTHR13235:SF2 SINGLE-STRAND SELECTIVE MONOFUNCTIONAL URACIL DNA GLYCOSYLASE SINGLE-STRAND SELECTIVE MONOFUNCTIONAL URACIL DNA GLYCOSYLASE DNA N-glycosylase activity#GO:0019104;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;catalytic activity, acting on DNA#GO:0140097 macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;cellular response to stress#GO:0033554;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;nucleobase-containing compound metabolic process#GO:0006139;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stress#GO:0006950;base-excision repair#GO:0006284;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 DNA glycosylase#PC00010 HUMAN|HGNC=12613|UniProtKB=Q9Y4E8 Q9Y4E8 USP15 PTHR21646:SF28 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 15 catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;cysteine-type peptidase activity#GO:0008234;cysteine-type deubiquitinase activity#GO:0004843;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005 chromatin remodeling#GO:0006338;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;regulation of biological quality#GO:0065008;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;nucleobase-containing compound metabolic process#GO:0006139;chromatin organization#GO:0006325;biosynthetic process#GO:0009058;biological regulation#GO:0065007;gene expression#GO:0010467;transcription elongation by RNA polymerase II#GO:0006368;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;regulation of protein stability#GO:0031647;DNA-templated transcription elongation#GO:0006354;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;transcription by RNA polymerase II#GO:0006366;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 cysteine protease#PC00081 HUMAN|HGNC=25598|UniProtKB=Q9NV66 Q9NV66 TYW1 PTHR13930:SF0 S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE TYW1-RELATED tRNA modification#GO:0006400;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 lyase#PC00144 HUMAN|HGNC=37240|UniProtKB=Q8TC17 Q8TC17 GRAPL PTHR19969:SF22 SH2-SH3 ADAPTOR PROTEIN-RELATED GRB2-RELATED ADAPTER PROTEIN-LIKE molecular adaptor activity#GO:0060090;receptor tyrosine kinase binding#GO:0030971;protein-macromolecule adaptor activity#GO:0030674;signaling receptor binding#GO:0005102;kinase binding#GO:0019900;protein tyrosine kinase binding#GO:1990782;binding#GO:0005488;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;protein binding#GO:0005515;signaling adaptor activity#GO:0035591 cell surface receptor signaling pathway#GO:0007166;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell motility#GO:0048870;cell migration#GO:0016477;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=21675|UniProtKB=Q5CZC0 Q5CZC0 FSIP2 PTHR21856:SF7 FIBROUS SHEATH-INTERACTING PROTEIN 2 FIBROUS SHEATH-INTERACTING PROTEIN 2 HUMAN|HGNC=4761|UniProtKB=P06899 P06899 H2BC11 PTHR23428:SF326 HISTONE H2B HISTONE H2B TYPE 1-J antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;immune system process#GO:0002376;response to bacterium#GO:0009617;defense response to bacterium#GO:0042742;response to stimulus#GO:0050896;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;antibacterial humoral response#GO:0019731;innate immune response#GO:0045087;response to external stimulus#GO:0009605;defense response#GO:0006952;humoral immune response#GO:0006959;antimicrobial humoral response#GO:0019730;defense response to other organism#GO:0098542;response to other organism#GO:0051707;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;immune response#GO:0006955;defense response to symbiont#GO:0140546 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|Ensembl=ENSG00000288520.1|UniProtKB=G9CGD6 G9CGD6 CNK3_IPCEF1 PTHR12844:SF45 CONNECTOR ENCHANCER OF KINASE SUPPRESSOR OF RAS CNK3_IPCEF1 FUSION PROTEIN-RELATED molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;postsynaptic specialization organization#GO:0099084;synapse organization#GO:0050808;response to stimulus#GO:0050896;cell junction organization#GO:0034330;regulation of cellular process#GO:0050794;signaling#GO:0023052;postsynapse organization#GO:0099173;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular component organization or biogenesis#GO:0071840;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;organelle organization#GO:0006996;signal transduction#GO:0007165;cellular process#GO:0009987 cell junction#GO:0030054;glutamatergic synapse#GO:0098978;synapse#GO:0045202;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HUMAN|HGNC=29954|UniProtKB=Q8NAP1 Q8NAP1 CASTOR3P PTHR31131:SF12 CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE PROTEIN CASTOR3P-RELATED negative regulation of cell communication#GO:0010648;response to nitrogen compound#GO:1901698;negative regulation of intracellular signal transduction#GO:1902532;regulation of signaling#GO:0023051;response to oxygen-containing compound#GO:1901700;regulation of intracellular signal transduction#GO:1902531;cellular response to chemical stimulus#GO:0070887;negative regulation of signaling#GO:0023057;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;cellular response to amino acid stimulus#GO:0071230;negative regulation of TOR signaling#GO:0032007;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of TORC1 signaling#GO:1903432;regulation of response to stimulus#GO:0048583;negative regulation of TORC1 signaling#GO:1904262;negative regulation of cellular process#GO:0048523;negative regulation of signal transduction#GO:0009968;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;cellular response to nitrogen compound#GO:1901699;negative regulation of response to stimulus#GO:0048585;response to chemical#GO:0042221;regulation of TOR signaling#GO:0032006;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;response to acid chemical#GO:0001101 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=34500|UniProtKB=P0DMW5 P0DMW5 SMIM10L2B PTHR34446:SF3 SMALL INTEGRAL MEMBRANE PROTEIN 10 SMALL INTEGRAL MEMBRANE PROTEIN 10-LIKE PROTEIN 2A-RELATED HUMAN|HGNC=38675|UniProtKB=Q7Z7L8 Q7Z7L8 C11orf96 PTHR40250:SF1 CHROMOSOME 11 OPEN READING FRAME 96 SI:CH1073-281M9.1 HUMAN|HGNC=21114|UniProtKB=Q6UWU4 Q6UWU4 C6orf89 PTHR35259:SF1 BOMBESIN RECEPTOR-ACTIVATED PROTEIN C6ORF89 BOMBESIN RECEPTOR-ACTIVATED PROTEIN C6ORF89 membrane#GO:0016020;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;intracellular organelle#GO:0043229;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=4415|UniProtKB=Q14749 Q14749 GNMT PTHR16458:SF2 GLYCINE N-METHYLTRANSFERASE GLYCINE N-METHYLTRANSFERASE N-methyltransferase activity#GO:0008170;catalytic activity#GO:0003824;transferase activity#GO:0016740;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;transferase activity, transferring one-carbon groups#GO:0016741;methyltransferase activity#GO:0008168 nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;proteinogenic amino acid metabolic process#GO:0170039;nucleobase-containing compound metabolic process#GO:0006139;amino acid metabolic process#GO:0006520;sulfur compound metabolic process#GO:0006790;carbohydrate derivative metabolic process#GO:1901135;homocysteine metabolic process#GO:0050667;cellular process#GO:0009987;oxoacid metabolic process#GO:0043436;purine nucleoside metabolic process#GO:0042278;small molecule metabolic process#GO:0044281;nucleoside metabolic process#GO:0009116;modified amino acid metabolic process#GO:0006575;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;purine-containing compound metabolic process#GO:0072521 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 methyltransferase#PC00155;transferase#PC00220 HUMAN|HGNC=27161|UniProtKB=Q6ICB4 Q6ICB4 PHETA2 PTHR22902:SF15 SESQUIPEDALIAN SESQUIPEDALIAN-2 vesicle organization#GO:0016050;endosome organization#GO:0007032;endosomal transport#GO:0016197;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;transport#GO:0006810;intracellular transport#GO:0046907;metabolic process#GO:0008152;endomembrane system organization#GO:0010256;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;retrograde transport, endosome to Golgi#GO:0042147;organelle organization#GO:0006996;cellular localization#GO:0051641;localization#GO:0051179;cytosolic transport#GO:0016482;cellular component organization#GO:0016043 trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;endomembrane system#GO:0012505;Golgi apparatus subcompartment#GO:0098791;recycling endosome#GO:0055037;Golgi apparatus#GO:0005794;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;organelle subcompartment#GO:0031984;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768 membrane traffic protein#PC00150 HUMAN|HGNC=11020|UniProtKB=O95436 O95436 SLC34A2 PTHR10010:SF23 SOLUTE CARRIER FAMILY 34 SODIUM PHOSPHATE , MEMBER 2-RELATED SODIUM-DEPENDENT PHOSPHATE TRANSPORT PROTEIN 2B symporter activity#GO:0015293;phosphate transmembrane transporter activity#GO:0005315;solute:sodium symporter activity#GO:0015370;monoatomic cation transmembrane transporter activity#GO:0008324;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;solute:monoatomic cation symporter activity#GO:0015294;monoatomic ion transmembrane transporter activity#GO:0015075;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081 homeostatic process#GO:0042592;phosphate ion transport#GO:0006817;localization#GO:0051179;establishment of localization#GO:0051234;intracellular chemical homeostasis#GO:0055082;inorganic anion transport#GO:0015698;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;inorganic ion homeostasis#GO:0098771;transport#GO:0006810 cluster of actin-based cell projections#GO:0098862;membrane-bounded organelle#GO:0043227;apical part of cell#GO:0045177;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;organelle#GO:0043226;cell periphery#GO:0071944;brush border#GO:0005903;vesicle#GO:0031982;membrane#GO:0016020;apical plasma membrane#GO:0016324 secondary carrier transporter#PC00258 HUMAN|HGNC=14854|UniProtKB=Q8NH49 Q8NH49 OR4X1 PTHR48002:SF44 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 4X1 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=16110|UniProtKB=Q96HY6 Q96HY6 DDRGK1 PTHR48176:SF4 DDRGK DOMAIN-CONTAINING PROTEIN 1 DDRGK DOMAIN-CONTAINING PROTEIN 1 ubiquitin-like protein ligase binding#GO:0044389;binding#GO:0005488;enzyme binding#GO:0019899;protein binding#GO:0005515 negative regulation of response to stimulus#GO:0048585;tissue development#GO:0009888;multicellular organismal process#GO:0032501;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of response to stress#GO:0080134;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;developmental process#GO:0032502;animal organ development#GO:0048513;multicellular organism development#GO:0007275;connective tissue development#GO:0061448;negative regulation of biological process#GO:0048519;regulation of response to endoplasmic reticulum stress#GO:1905897;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of intracellular signal transduction#GO:1902531;animal gross anatomical part developmental process#GO:0160108;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;anatomical structure development#GO:0048856;negative regulation of intracellular signal transduction#GO:1902532;skeletal system development#GO:0001501;negative regulation of cell communication#GO:0010648;cartilage development#GO:0051216;regulation of cellular response to stress#GO:0080135;system development#GO:0048731 HUMAN|HGNC=14342|UniProtKB=Q9BXJ2 Q9BXJ2 C1QTNF7 PTHR15427:SF24 EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER COMPLEMENT C1Q TUMOR NECROSIS FACTOR-RELATED PROTEIN 7 molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=12760|UniProtKB=Q9NSI6 Q9NSI6 BRWD1 PTHR16266:SF26 WD REPEAT DOMAIN 9 BROMODOMAIN AND WD REPEAT-CONTAINING PROTEIN 1 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=24945|UniProtKB=Q8IV16 Q8IV16 GPIHBP1 PTHR16983:SF12 UPAR/LY6 DOMAIN-CONTAINING PROTEIN GLYCOSYLPHOSPHATIDYLINOSITOL-ANCHORED HIGH DENSITY LIPOPROTEIN-BINDING PROTEIN 1 protein binding#GO:0005515;protein-containing complex binding#GO:0044877;lipoprotein particle binding#GO:0071813;binding#GO:0005488;protein-lipid complex binding#GO:0071814;enzyme binding#GO:0019899 triglyceride homeostasis#GO:0070328;lipid homeostasis#GO:0055088;chemical homeostasis#GO:0048878;homeostatic process#GO:0042592 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 protein-binding activity modulator#PC00095 HUMAN|Ensembl=ENSG00000274792.1|UniProtKB=A0A0G2JNH3 A0A0G2JNH3 LOC124905359 PTHR48002:SF4 OLFACTORY RECEPTOR OLFACTORY RECEPTOR-RELATED molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=9632|UniProtKB=Q86YD1 Q86YD1 PTOV1 PTHR12433:SF3 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 25 PROSTATE TUMOR-OVEREXPRESSED GENE 1 PROTEIN positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA metabolic process#GO:0051252;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794 intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;mediator complex#GO:0016592;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231 general transcription factor#PC00259;RNA metabolism protein#PC00031 HUMAN|HGNC=21306|UniProtKB=Q9BT30 Q9BT30 ALKBH7 PTHR21052:SF0 SPERMATOGENESIS ASSOCIATED 11-RELATED RNA DEMETHYLASE ALKBH7, MITOCHONDRIAL dioxygenase activity#GO:0051213;oxidoreductase activity#GO:0016491;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;chromatin#GO:0000785;nucleus#GO:0005634;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=51513|UniProtKB=P0DUD2 P0DUD2 SPDYE17 PTHR31156:SF15 WBSCR19-LIKE PROTEIN SPEEDY PROTEIN E10-RELATED HUMAN|HGNC=10737|UniProtKB=Q9P283 Q9P283 SEMA5B PTHR11036:SF39 SEMAPHORIN SEMAPHORIN-5B molecular function activator activity#GO:0140677;protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018 cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;neuron projection development#GO:0031175;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;axon extension#GO:0048675;cell surface receptor signaling pathway#GO:0007166;growth#GO:0040007;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;cell projection morphogenesis#GO:0048858;cell growth#GO:0016049;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;positive regulation of cell motility#GO:2000147;cell development#GO:0048468;signaling#GO:0023052;cell morphogenesis#GO:0000902;cell differentiation#GO:0030154;cell projection organization#GO:0030030;response to stimulus#GO:0050896;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;neuron projection extension#GO:1990138;axonogenesis#GO:0007409;developmental growth involved in morphogenesis#GO:0060560;neuron development#GO:0048666;positive regulation of cell migration#GO:0030335;positive regulation of cellular process#GO:0048522;axon development#GO:0061564;axon guidance#GO:0007411;regulation of locomotion#GO:0040012;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;regulation of cell migration#GO:0030334;neurogenesis#GO:0022008;neuron projection guidance#GO:0097485;positive regulation of locomotion#GO:0040017;developmental growth#GO:0048589;cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;developmental cell growth#GO:0048588;regulation of cellular process#GO:0050794;system development#GO:0048731;anatomical structure development#GO:0048856;regulation of cell motility#GO:2000145;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 membrane-bound signaling molecule#PC00152 HUMAN|HGNC=29330|UniProtKB=Q9HCE5 Q9HCE5 METTL14 PTHR13107:SF0 N6-ADENOSINE-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT N(6)-ADENOSINE-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT METTL14 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729 nucleobase-containing compound metabolic process#GO:0006139;mRNA metabolic process#GO:0016071;cellular process#GO:0009987;mRNA modification#GO:0016556;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;RNA modification#GO:0009451;metabolic process#GO:0008152 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;methyltransferase complex#GO:0034708;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HUMAN|HGNC=815|UniProtKB=Q01814 Q01814 ATP2B2 PTHR24093:SF377 CATION TRANSPORTING ATPASE PLASMA MEMBRANE CALCIUM-TRANSPORTING ATPASE 2 ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;P-type ion transporter activity#GO:0015662;monoatomic ion transmembrane transporter activity#GO:0015075;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873;primary active transmembrane transporter activity#GO:0015399 cellular homeostasis#GO:0019725;intracellular calcium ion homeostasis#GO:0006874;intracellular chemical homeostasis#GO:0055082;calcium ion homeostasis#GO:0055074;inorganic ion homeostasis#GO:0098771;chemical homeostasis#GO:0048878;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;homeostatic process#GO:0042592;monoatomic ion homeostasis#GO:0050801;intracellular monoatomic ion homeostasis#GO:0006873;regulation of cytosolic calcium ion concentration#GO:0051480 membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane region#GO:0098590;postsynaptic specialization#GO:0099572;neuron to neuron synapse#GO:0098984;plasma membrane#GO:0005886;synaptic membrane#GO:0097060;cell junction#GO:0030054;postsynapse#GO:0098794;organelle#GO:0043226;asymmetric synapse#GO:0032279;synapse#GO:0045202;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;intracellular organelle#GO:0043229;postsynaptic density#GO:0014069;membrane-bounded organelle#GO:0043227;postsynaptic density membrane#GO:0098839;intracellular anatomical structure#GO:0005622 primary active transporter#PC00068 HUMAN|HGNC=16948|UniProtKB=Q969H8 Q969H8 MYDGF PTHR31230:SF1 MYELOID-DERIVED GROWTH FACTOR MYDGF MYELOID-DERIVED GROWTH FACTOR regulation of anatomical structure morphogenesis#GO:0022603;positive regulation of developmental process#GO:0051094;regulation of vasculature development#GO:1901342;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of angiogenesis#GO:0045765;regulation of cell population proliferation#GO:0042127;regulation of developmental process#GO:0050793;positive regulation of epithelial cell proliferation#GO:0050679;regulation of cellular process#GO:0050794;regulation of multicellular organismal development#GO:2000026;positive regulation of multicellular organismal process#GO:0051240;regulation of biological process#GO:0050789;positive regulation of angiogenesis#GO:0045766;positive regulation of cell population proliferation#GO:0008284 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 growth factor#PC00112 HUMAN|HGNC=33813|UniProtKB=Q6ZUF6 Q6ZUF6 LINC00336 PTHR12138:SF159 PRIMATE-EXPANDED PROTEIN FAMILY SUBFAMILY NOT NAMED HUMAN|HGNC=3828|UniProtKB=P25089 P25089 FPR3 PTHR24225:SF16 CHEMOTACTIC RECEPTOR N-FORMYL PEPTIDE RECEPTOR 3 G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653;immune receptor activity#GO:0140375;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023 phospholipase C-activating G protein-coupled receptor signaling pathway#GO:0007200;regulation of immune response#GO:0050776;positive regulation of cytosolic calcium ion concentration#GO:0007204;G protein-coupled receptor signaling pathway#GO:0007186;immune system process#GO:0002376;regulation of biological quality#GO:0065008;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;immune response-regulating signaling pathway#GO:0002764;regulation of biological process#GO:0050789;immune response-activating cell surface receptor signaling pathway#GO:0002429;signaling#GO:0023052;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166;positive regulation of immune response#GO:0050778;immune response-activating signaling pathway#GO:0002757;cellular process#GO:0009987;activation of immune response#GO:0002253;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of immune system process#GO:0002684;immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CHKR#P00854 HUMAN|HGNC=15906|UniProtKB=A7E2Y1 A7E2Y1 MYH7B PTHR45615:SF29 MYOSIN HEAVY CHAIN, NON-MUSCLE MYOSIN-7B ATP-dependent activity#GO:0140657;actin filament binding#GO:0051015;actin binding#GO:0003779;polypeptide conformation or assembly isomerase activity#GO:0120544;binding#GO:0005488;protein-containing complex binding#GO:0044877;protein binding#GO:0005515;macromolecular conformation isomerase activity#GO:0120543;cytoskeletal protein binding#GO:0008092;catalytic activity#GO:0003824;microfilament motor activity#GO:0000146;isomerase activity#GO:0016853;cytoskeletal motor activity#GO:0003774 intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;supramolecular complex#GO:0099080;organelle#GO:0043226;actin cytoskeleton#GO:0015629;myosin complex#GO:0016459 actin or actin-binding cytoskeletal protein#PC00041 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Myosin#P00867;Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097;Wnt signaling pathway#P00057>NFAT Target Genes#G01559;Cytoskeletal regulation by Rho GTPase#P00016>Myosin#P00522 HUMAN|HGNC=8356|UniProtKB=O76100 O76100 OR7A10 PTHR48001:SF112 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 7A10 transmembrane signal receptor#PC00197 HUMAN|HGNC=9912|UniProtKB=P0DJD3 P0DJD3 RBMY1A1 PTHR48034:SF17 TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED RNA-BINDING MOTIF PROTEIN, Y CHROMOSOME, FAMILY 1 MEMBER A1-RELATED RNA binding#GO:0003723;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488 macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634;spliceosomal complex#GO:0005681;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904 RNA metabolism protein#PC00031 HUMAN|HGNC=15146|UniProtKB=Q8NGH3 Q8NGH3 OR2D3 PTHR26453:SF136 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2D3 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 nervous system process#GO:0050877;sensory perception#GO:0007600;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;detection of chemical stimulus#GO:0009593;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;response to stimulus#GO:0050896;response to chemical#GO:0042221 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=8096|UniProtKB=O95190 O95190 OAZ2 PTHR10279:SF6 ORNITHINE DECARBOXYLASE ANTIZYME ORNITHINE DECARBOXYLASE ANTIZYME 2 enzyme inhibitor activity#GO:0004857;molecular function regulator activity#GO:0098772;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234 nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 protein-binding activity modulator#PC00095 HUMAN|HGNC=24157|UniProtKB=O00154 O00154 ACOT7 PTHR11049:SF27 ACYL COENZYME A THIOESTER HYDROLASE CYTOSOLIC ACYL COENZYME A THIOESTER HYDROLASE hydrolase activity, acting on ester bonds#GO:0016788;thiolester hydrolase activity#GO:0016790;acyl-CoA hydrolase activity#GO:0016289;deacylase activity#GO:0160215;fatty acyl-CoA hydrolase activity#GO:0047617;catalytic activity#GO:0003824;hydrolase activity#GO:0016787 oxoacid metabolic process#GO:0043436;fatty acid catabolic process#GO:0009062;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;purine-containing compound metabolic process#GO:0072521;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;small molecule catabolic process#GO:0044282;nucleoside phosphate metabolic process#GO:0006753;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;acyl-CoA metabolic process#GO:0006637;nucleobase-containing small molecule metabolic process#GO:0055086;sulfur compound metabolic process#GO:0006790;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;lipid catabolic process#GO:0016042;carboxylic acid catabolic process#GO:0046395;monocarboxylic acid catabolic process#GO:0072329;nucleobase-containing compound metabolic process#GO:0006139 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 esterase#PC00097 HUMAN|HGNC=19263|UniProtKB=Q9H0V9 Q9H0V9 LMAN2L PTHR12223:SF20 VESICULAR MANNOSE-BINDING LECTIN VIP36-LIKE PROTEIN monosaccharide binding#GO:0048029;carbohydrate binding#GO:0030246;small molecule binding#GO:0036094;binding#GO:0005488 establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;transport#GO:0006810;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649 COPII-coated ER to Golgi transport vesicle#GO:0030134;cytoplasmic vesicle#GO:0031410;coated vesicle#GO:0030135;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;endoplasmic reticulum membrane#GO:0005789;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;endoplasmic reticulum#GO:0005783;endomembrane system#GO:0012505;cytoplasm#GO:0005737;membrane#GO:0016020 membrane traffic protein#PC00150 HUMAN|HGNC=24560|UniProtKB=Q9Y3X0 Q9Y3X0 CCDC9 PTHR15635:SF11 COILED-COIL DOMAIN CONTAINING PROTEIN 9 COILED-COIL DOMAIN-CONTAINING PROTEIN 9 HUMAN|HGNC=1077|UniProtKB=O00238 O00238 BMPR1B PTHR23255:SF62 TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B transmembrane receptor protein kinase activity#GO:0019199;signaling receptor activity#GO:0038023;catalytic activity, acting on a protein#GO:0140096;transforming growth factor beta receptor activity#GO:0005024;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein kinase activity#GO:0004672;molecular transducer activity#GO:0060089;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein serine/threonine kinase activity#GO:0004675;transmembrane signaling receptor activity#GO:0004888;protein serine/threonine kinase activity#GO:0004674 cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;cellular response to growth factor stimulus#GO:0071363;pattern specification process#GO:0007389;cellular response to endogenous stimulus#GO:0071495;cell differentiation#GO:0030154;response to growth factor#GO:0070848;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;dorsal/ventral pattern formation#GO:0009953;cellular response to stimulus#GO:0051716;BMP signaling pathway#GO:0030509;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;cellular response to BMP stimulus#GO:0071773;developmental process#GO:0032502;response to BMP#GO:0071772;cell surface receptor signaling pathway#GO:0007166;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;multicellular organismal process#GO:0032501;regionalization#GO:0003002;biological regulation#GO:0065007;signal transduction#GO:0007165;cellular process#GO:0009987 signaling receptor complex#GO:0043235;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 serine/threonine protein kinase receptor#PC00205 TGF-beta signaling pathway#P00052>TGFbetareceptors#P01283;Gonadotropin-releasing hormone receptor pathway#P06664>BMPR-IA/IB/II#P06740;TGF-beta signaling pathway#P00052>TGFbetareceptor I#P01278;Wnt signaling pathway#P00057>TGFbetaactivated Kinase-1#P01442 HUMAN|HGNC=26697|UniProtKB=Q8N9V3 Q8N9V3 WDSUB1 PTHR46573:SF1 WD REPEAT, SAM AND U-BOX DOMAIN-CONTAINING PROTEIN 1 WD REPEAT, SAM AND U-BOX DOMAIN-CONTAINING PROTEIN 1 HUMAN|HGNC=30186|UniProtKB=Q9UHW5 Q9UHW5 GPN3 PTHR21231:SF7 XPA-BINDING PROTEIN 1-RELATED GPN-LOOP GTPASE 3 hydrolase activity, acting on acid anhydrides#GO:0016817;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787 small GTPase#PC00208;protein-binding activity modulator#PC00095;G-protein#PC00020 HUMAN|HGNC=3221|UniProtKB=P20827 P20827 EFNA1 PTHR11304:SF19 EPHRIN EPHRIN-A1 signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515 regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;cell development#GO:0048468;signaling#GO:0023052;cell morphogenesis#GO:0000902;cell differentiation#GO:0030154;response to stimulus#GO:0050896;cell projection organization#GO:0030030;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;neuron development#GO:0048666;axonogenesis#GO:0007409;cellular process#GO:0009987;signal transduction#GO:0007165;neuron projection development#GO:0031175;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell surface receptor signaling pathway#GO:0007166;neuron differentiation#GO:0030182;cell projection morphogenesis#GO:0048858;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;ephrin receptor signaling pathway#GO:0048013;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;system development#GO:0048731;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;cell communication#GO:0007154;axon guidance#GO:0007411;axon development#GO:0061564;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;neurogenesis#GO:0022008;neuron projection guidance#GO:0097485;cellular developmental process#GO:0048869 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 membrane-bound signaling molecule#PC00152;intercellular signal molecule#PC00207 HUMAN|HGNC=13003|UniProtKB=Q13398 Q13398 ZNF211 PTHR24377:SF661 IP01015P-RELATED ZINC FINGER PROTEIN 211 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=11839|UniProtKB=Q04726 Q04726 TLE3 PTHR10814:SF24 TRANSDUCIN-LIKE ENHANCER PROTEIN TRANSDUCIN-LIKE ENHANCER PROTEIN 3 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714 negative regulation of cell communication#GO:0010648;regulation of signaling#GO:0023051;negative regulation of canonical Wnt signaling pathway#GO:0090090;negative regulation of signaling#GO:0023057;regulation of Wnt signaling pathway#GO:0030111;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;negative regulation of signal transduction#GO:0009968;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of response to stimulus#GO:0048585;negative regulation of Wnt signaling pathway#GO:0030178;regulation of canonical Wnt signaling pathway#GO:0060828 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 transcription cofactor#PC00217 Wnt signaling pathway#P00057>Transducin-like Enhance of Split 1-3#P01436 HUMAN|HGNC=2521|UniProtKB=P17538 P17538 CTRB1 PTHR24250:SF65 CHYMOTRYPSIN-RELATED CHYMOTRYPSINOGEN B catalytic activity#GO:0003824;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;serine-type peptidase activity#GO:0008236;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787 proteolysis#GO:0006508;metabolic process#GO:0008152;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 protein modifying enzyme#PC00260;serine protease#PC00203 HUMAN|HGNC=6373|UniProtKB=Q12918 Q12918 KLRB1 PTHR46784:SF1 KILLER CELL LECTIN-LIKE RECEPTOR SUBFAMILY B MEMBER 1 KILLER CELL LECTIN-LIKE RECEPTOR SUBFAMILY B MEMBER 1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 biological regulation#GO:0065007;regulation of natural killer cell mediated cytotoxicity#GO:0042269;regulation of response to external stimulus#GO:0032101;regulation of response to stimulus#GO:0048583;regulation of response to stress#GO:0080134;regulation of innate immune response#GO:0045088;regulation of leukocyte mediated immunity#GO:0002703;regulation of biological process#GO:0050789;regulation of natural killer cell mediated immunity#GO:0002715;regulation of response to biotic stimulus#GO:0002831;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of immune response#GO:0050776;regulation of cell killing#GO:0031341;regulation of defense response#GO:0031347;regulation of lymphocyte mediated immunity#GO:0002706;regulation of leukocyte mediated cytotoxicity#GO:0001910;regulation of immune effector process#GO:0002697 plasma membrane#GO:0005886;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=3511|UniProtKB=Q9UQ84 Q9UQ84 EXO1 PTHR11081:SF8 FLAP ENDONUCLEASE FAMILY MEMBER EXONUCLEASE 1 hydrolase activity#GO:0016787;DNA endonuclease activity#GO:0004520;nuclease activity#GO:0004518;catalytic activity, acting on DNA#GO:0140097;endonuclease activity#GO:0004519;DNA endonuclease activity, producing 5'-phosphomonoesters#GO:0016888;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;DNA nuclease activity#GO:0004536 DNA metabolism protein#PC00009;exodeoxyribonuclease#PC00098 HUMAN|HGNC=13154|UniProtKB=P17098 P17098 ZNF8 PTHR24377:SF622 IP01015P-RELATED ZINC FINGER PROTEIN 8 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=33904|UniProtKB=A6NK06 A6NK06 ACOD1 PTHR16943:SF11 2-METHYLCITRATE DEHYDRATASE-RELATED CIS-ACONITATE DECARBOXYLASE carbon-carbon lyase activity#GO:0016830;catalytic activity#GO:0003824;carboxy-lyase activity#GO:0016831;lyase activity#GO:0016829 defense response#GO:0006952;positive regulation of response to biotic stimulus#GO:0002833;regulation of innate immune response#GO:0045088;lipid metabolic process#GO:0006629;regulation of response to stimulus#GO:0048583;positive regulation of defense response#GO:0031349;positive regulation of immune response#GO:0050778;regulation of response to stress#GO:0080134;fatty acid metabolic process#GO:0006631;negative regulation of immune system process#GO:0002683;biological regulation#GO:0065007;negative regulation of response to stimulus#GO:0048585;positive regulation of response to stimulus#GO:0048584;regulation of inflammatory response#GO:0050727;regulation of defense response#GO:0031347;negative regulation of immune response#GO:0050777;regulation of immune response#GO:0050776;regulation of response to biotic stimulus#GO:0002831;negative regulation of defense response#GO:0031348;negative regulation of inflammatory response#GO:0050728;regulation of immune system process#GO:0002682;primary metabolic process#GO:0044238;positive regulation of response to external stimulus#GO:0032103;metabolic process#GO:0008152;negative regulation of innate immune response#GO:0045824;negative regulation of response to external stimulus#GO:0032102;regulation of response to external stimulus#GO:0032101;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of immune system process#GO:0002684;response to stress#GO:0006950;oxoacid metabolic process#GO:0043436;response to stimulus#GO:0050896;small molecule metabolic process#GO:0044281;regulation of biological process#GO:0050789;carboxylic acid metabolic process#GO:0019752;negative regulation of biological process#GO:0048519;monocarboxylic acid metabolic process#GO:0032787 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 metabolite interconversion enzyme#PC00262;lyase#PC00144;dehydratase#PC00091 HUMAN|HGNC=14836|UniProtKB=Q8NH81 Q8NH81 OR10G6 PTHR26453:SF179 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 10G6 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 response to stimulus#GO:0050896;response to chemical#GO:0042221;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;detection of chemical stimulus#GO:0009593;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;system process#GO:0003008;sensory perception#GO:0007600;nervous system process#GO:0050877;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=23222|UniProtKB=Q96N96 Q96N96 SPATA13 PTHR45834:SF5 RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 9-RELATED SPERMATOGENESIS-ASSOCIATED PROTEIN 13 molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;guanyl-nucleotide exchange factor activity#GO:0005085 cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;filopodium assembly#GO:0046847;lamellipodium assembly#GO:0030032;cell projection assembly#GO:0030031;cellular component assembly#GO:0022607;cell projection organization#GO:0030030;plasma membrane bounded cell projection organization#GO:0120036;plasma membrane bounded cell projection assembly#GO:0120031;cellular component organization or biogenesis#GO:0071840 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 guanyl-nucleotide exchange factor#PC00113;protein-binding activity modulator#PC00095;G-protein modulator#PC00022 HUMAN|HGNC=24552|UniProtKB=Q3LXA3 Q3LXA3 TKFC PTHR28629:SF4 TRIOKINASE/FMN CYCLASE TRIOKINASE_FMN CYCLASE transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773 cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate metabolic process#GO:0005975;small molecule catabolic process#GO:0044282;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;metabolic process#GO:0008152;alcohol metabolic process#GO:0006066;carbohydrate catabolic process#GO:0016052 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 cyclase#PC00079 HUMAN|HGNC=25268|UniProtKB=Q96LR9 Q96LR9 APOLD1 PTHR14096:SF1 APOLIPOPROTEIN L APOLIPOPROTEIN L DOMAIN-CONTAINING PROTEIN 1 binding#GO:0005488;lipid binding#GO:0008289 animal gross anatomical part developmental process#GO:0160108;angiogenesis#GO:0001525;anatomical structure development#GO:0048856;system development#GO:0048731;blood vessel morphogenesis#GO:0048514;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;blood vessel development#GO:0001568;regulation of multicellular organismal development#GO:2000026;tube morphogenesis#GO:0035239;circulatory system development#GO:0072359;regulation of cellular process#GO:0050794;regulation of developmental process#GO:0050793;developmental process#GO:0032502;regulation of cell differentiation#GO:0045595;multicellular organism development#GO:0007275;vasculature development#GO:0001944;anatomical structure formation involved in morphogenesis#GO:0048646;regulation of epithelial cell differentiation#GO:0030856;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;tube development#GO:0035295;regulation of multicellular organismal process#GO:0051239 membrane#GO:0016020;cellular anatomical structure#GO:0110165 apolipoprotein#PC00052;transfer/carrier protein#PC00219 HUMAN|HGNC=3553|UniProtKB=O00519 O00519 FAAH PTHR45847:SF3 FATTY ACID AMIDE HYDROLASE FATTY-ACID AMIDE HYDROLASE 1 catalytic activity#GO:0003824;amidase activity#GO:0004040;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810 lipid metabolic process#GO:0006629;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;fatty acid catabolic process#GO:0009062;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;lipid catabolic process#GO:0016042;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;small molecule catabolic process#GO:0044282;monocarboxylic acid catabolic process#GO:0072329;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056 hydrolase#PC00121 Anandamide degradation#P05728>FAAH#P05741 HUMAN|HGNC=20751|UniProtKB=Q8IZQ1 Q8IZQ1 WDFY3 PTHR46108:SF1 BLUE CHEESE WD REPEAT AND FYVE DOMAIN-CONTAINING PROTEIN 3 macroautophagy#GO:0016236;process utilizing autophagic mechanism#GO:0061919;catabolic process#GO:0009056;cellular process#GO:0009987;autophagy#GO:0006914;metabolic process#GO:0008152 HUMAN|HGNC=2518|UniProtKB=O60931 O60931 CTNS PTHR13131:SF14 CYSTINOSIN CYSTINOSIN transporter activity#GO:0005215;carboxylic acid transmembrane transporter activity#GO:0046943;transmembrane transporter activity#GO:0022857;amino acid transmembrane transporter activity#GO:0015171;L-amino acid transmembrane transporter activity#GO:0015179 cellular process#GO:0009987;transport#GO:0006810;transmembrane transport#GO:0055085;vacuolar transmembrane transport#GO:0034486;establishment of localization#GO:0051234;localization#GO:0051179 cytoplasm#GO:0005737;vacuole#GO:0005773;lysosomal membrane#GO:0005765;membrane#GO:0016020;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;vacuolar membrane#GO:0005774;lytic vacuole#GO:0000323;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;lysosome#GO:0005764;lytic vacuole membrane#GO:0098852;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 secondary carrier transporter#PC00258;amino acid transporter#PC00046 HUMAN|HGNC=25839|UniProtKB=Q8TE85 Q8TE85 GRHL3 PTHR11037:SF6 TRANSCRIPTION FACTOR CP2 GRAINYHEAD-LIKE PROTEIN 3 HOMOLOG DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulator activity#GO:0140110;DNA-binding transcription activator activity#GO:0001216;sequence-specific DNA binding#GO:0043565;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA-binding transcription factor#PC00218 HUMAN|HGNC=16236|UniProtKB=Q9H1R2 Q9H1R2 DUSP15 PTHR45948:SF4 DUAL SPECIFICITY PROTEIN PHOSPHATASE DDB_G0269404-RELATED DUAL SPECIFICITY PROTEIN PHOSPHATASE 15 phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725;phosphoprotein phosphatase activity#GO:0004721 regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;regulation of MAPK cascade#GO:0043408;positive regulation of MAPK cascade#GO:0043410;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of ERK1 and ERK2 cascade#GO:0070372;positive regulation of response to stimulus#GO:0048584;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;positive regulation of signaling#GO:0023056;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;positive regulation of ERK1 and ERK2 cascade#GO:0070374;regulation of cell communication#GO:0010646;signaling#GO:0023052;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;response to stimulus#GO:0050896 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 protein phosphatase#PC00195;protein modifying enzyme#PC00260 Oxidative stress response#P00046>MKP5#P01131 HUMAN|HGNC=8044|UniProtKB=P80303 P80303 NUCB2 PTHR19237:SF22 NUCLEOBINDIN NUCLEOBINDIN-2 small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;calcium ion binding#GO:0005509;metal ion binding#GO:0046872;cation binding#GO:0043169 endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 calcium-binding protein#PC00060;calmodulin-related#PC00061 HUMAN|HGNC=14548|UniProtKB=Q96TA0 Q96TA0 PCDHB18P PTHR24028:SF98 CADHERIN-87A PROTOCADHERIN BETA-18-RELATED cell adhesion#GO:0007155;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cadherin#PC00057;cell adhesion molecule#PC00069 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HUMAN|HGNC=11874|UniProtKB=Q9NZQ9 Q9NZQ9 TMOD4 PTHR10901:SF9 TROPOMODULIN TROPOMODULIN-4 binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;protein binding#GO:0005515 organelle assembly#GO:0070925;cellular component assembly involved in morphogenesis#GO:0010927;actin filament-based process#GO:0030029;anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;muscle cell development#GO:0055001;muscle cell differentiation#GO:0042692;myofibril assembly#GO:0030239;muscle structure development#GO:0061061;actin cytoskeleton organization#GO:0030036;developmental process#GO:0032502;muscle contraction#GO:0006936;cellular developmental process#GO:0048869;actin filament organization#GO:0007015;system process#GO:0003008;multicellular organismal process#GO:0032501;animal gross anatomical part developmental process#GO:0160108;striated muscle cell development#GO:0055002;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;muscle system process#GO:0003012;anatomical structure morphogenesis#GO:0009653;cell differentiation#GO:0030154;actomyosin structure organization#GO:0031032;cell development#GO:0048468;cellular anatomical entity morphogenesis#GO:0032989;cellular component organization or biogenesis#GO:0071840;anatomical structure formation involved in morphogenesis#GO:0048646;striated muscle cell differentiation#GO:0051146;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010 contractile muscle fiber#GO:0043292;actin cytoskeleton#GO:0015629;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;sarcomere#GO:0030017;myofibril#GO:0030016;membraneless organelle#GO:0043228 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=30220|UniProtKB=Q96AA3 Q96AA3 RFT1 PTHR13117:SF5 ENDOPLASMIC RETICULUM MULTISPAN TRANSMEMBRANE PROTEIN-RELATED MAN(5)GLCNAC(2)-PP-DOLICHOL TRANSLOCATION PROTEIN RFT1 lipid transport#GO:0006869;membrane organization#GO:0061024;biological regulation#GO:0065007;lipid translocation#GO:0034204;cellular component organization#GO:0016043;macromolecule localization#GO:0033036;cellular process#GO:0009987;carbohydrate derivative transport#GO:1901264;establishment of localization#GO:0051234;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;regulation of membrane lipid distribution#GO:0097035;regulation of biological quality#GO:0065008;lipid localization#GO:0010876;transport#GO:0006810 membrane#GO:0016020;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=3551|UniProtKB=P00740 P00740 F9 PTHR24278:SF31 COAGULATION FACTOR COAGULATION FACTOR IX serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175 proteolysis#GO:0006508;protein metabolic process#GO:0019538;regulation of biological quality#GO:0065008;wound healing#GO:0042060;hemostasis#GO:0007599;primary metabolic process#GO:0044238;zymogen activation#GO:0031638;response to stimulus#GO:0050896;regulation of body fluid levels#GO:0050878;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;blood coagulation#GO:0007596;response to wounding#GO:0009611;response to stress#GO:0006950;coagulation#GO:0050817;macromolecule biosynthetic process#GO:0009059;protein processing#GO:0016485;cellular process#GO:0009987;multicellular organismal process#GO:0032501;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;biological regulation#GO:0065007 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 serine protease#PC00203 Blood coagulation#P00011>FIX#P00444;Blood coagulation#P00011>FIXa#P00422;Blood coagulation#P00011>FXIa#P00434;Blood coagulation#P00011>FXI#P00460 HUMAN|HGNC=3123|UniProtKB=O00559 O00559 EBAG9 PTHR15208:SF2 RECEPTOR-BINDING CANCER ANTIGEN EXPRESSED ON SISO CELLS CANCER ASSOCIATED SURFACE ANTIGEN RCAS1 ESTROGEN RECEPTOR-BINDING FRAGMENT- ASSOCIATED GENE 9 PROTEIN RECEPTOR-BINDING CANCER ANTIGEN EXPRESSED ON SISO CELLS protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;protein-membrane adaptor activity#GO:0043495 regulation of localization#GO:0032879;regulation of transport#GO:0051049;regulation of secretion by cell#GO:1903530;regulation of exocytosis#GO:0017157;regulation of secretion#GO:0051046;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;biological regulation#GO:0065007;regulation of cellular process#GO:0050794 secretory vesicle#GO:0099503;intracellular vesicle#GO:0097708;vesicle#GO:0031982;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141 HUMAN|HGNC=7677|UniProtKB=Q96MG7 Q96MG7 NSMCE3 PTHR11736:SF36 MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 3 HOMOLOG regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 scaffold/adaptor protein#PC00226 HUMAN|HGNC=10992|UniProtKB=P12236 P12236 SLC25A6 PTHR45635:SF13 ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED ADP_ATP TRANSLOCASE 3 transfer/carrier protein#PC00219 HUMAN|HGNC=16501|UniProtKB=P50479 P50479 PDLIM4 PTHR24214:SF6 PDZ AND LIM DOMAIN PROTEIN ZASP PDZ AND LIM DOMAIN PROTEIN 4 cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;binding#GO:0005488;protein binding#GO:0005515 animal organ development#GO:0048513;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;developmental process#GO:0032502;multicellular organismal process#GO:0032501;heart development#GO:0007507;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular process#GO:0009987;anatomical structure development#GO:0048856;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;actin filament-based process#GO:0030029;actin cytoskeleton organization#GO:0030036;muscle structure development#GO:0061061;circulatory system development#GO:0072359;cellular component organization#GO:0016043 polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;cell junction#GO:0030054;sarcomere#GO:0030017;adherens junction#GO:0005912;stress fiber#GO:0001725;cytoskeleton#GO:0005856;actin filament#GO:0005884;I band#GO:0031674;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cell-cell junction#GO:0005911;actomyosin#GO:0042641;Z disc#GO:0030018;contractile muscle fiber#GO:0043292;actin filament bundle#GO:0032432;myofibril#GO:0030016;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;supramolecular fiber#GO:0099512;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;actin cytoskeleton#GO:0015629 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=10494|UniProtKB=P26447 P26447 S100A4 PTHR11639:SF51 S100 CALCIUM-BINDING PROTEIN PROTEIN S100-A4 signaling receptor binding#GO:0005102;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;calcium ion binding#GO:0005509;metal ion binding#GO:0046872;protein binding#GO:0005515;cation binding#GO:0043169 positive regulation of canonical NF-kappaB signal transduction#GO:0043123;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of canonical NF-kappaB signal transduction#GO:0043122;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;regulation of cell communication#GO:0010646;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;perinuclear region of cytoplasm#GO:0048471;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 calcium-binding protein#PC00060;calmodulin-related#PC00061 HUMAN|HGNC=21074|UniProtKB=Q9NU53 Q9NU53 GINM1 PTHR28549:SF1 GLYCOPROTEIN INTEGRAL MEMBRANE PROTEIN 1 GLYCOPROTEIN INTEGRAL MEMBRANE PROTEIN 1 HUMAN|HGNC=5995|UniProtKB=Q9NPH3 Q9NPH3 IL1RAP PTHR11890:SF20 INTERLEUKIN-1 RECEPTOR FAMILY MEMBER INTERLEUKIN-1 RECEPTOR ACCESSORY PROTEIN cytokine receptor activity#GO:0004896;transmembrane signaling receptor activity#GO:0004888;immune receptor activity#GO:0140375;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 response to peptide#GO:1901652;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;cytokine-mediated signaling pathway#GO:0019221;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to cytokine#GO:0034097;response to stimulus#GO:0050896;response to chemical#GO:0042221;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cellular response to cytokine stimulus#GO:0071345;signal transduction#GO:0007165;regulation of biological process#GO:0050789 plasma membrane#GO:0005886;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=2900|UniProtKB=Q12959 Q12959 DLG1 PTHR23119:SF5 DISCS LARGE DISKS LARGE HOMOLOG 1 structural constituent of synapse#GO:0098918;protein binding#GO:0005515;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;binding#GO:0005488;signaling receptor binding#GO:0005102;kinase binding#GO:0019900;structural molecule activity#GO:0005198 anterograde trans-synaptic signaling#GO:0098916;chemical synaptic transmission#GO:0007268;system development#GO:0048731;anatomical structure development#GO:0048856;localization#GO:0051179;establishment or maintenance of epithelial cell apical/basal polarity#GO:0045197;cell communication#GO:0007154;establishment or maintenance of bipolar cell polarity#GO:0061245;localization within membrane#GO:0051668;trans-synaptic signaling#GO:0099537;establishment or maintenance of apical/basal cell polarity#GO:0035088;protein localization to cell junction#GO:1902414;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;multicellular organismal process#GO:0032501;macromolecule localization#GO:0033036;intracellular protein localization#GO:0008104;developmental process#GO:0032502;regulation of postsynaptic membrane neurotransmitter receptor levels#GO:0099072;signaling#GO:0023052;regulation of biological process#GO:0050789;protein localization to membrane#GO:0072657;regulation of biological quality#GO:0065008;cellular localization#GO:0051641;receptor clustering#GO:0043113;cell adhesion#GO:0007155;animal gross anatomical part developmental process#GO:0160108;establishment or maintenance of cell polarity#GO:0007163;nervous system development#GO:0007399;cellular process#GO:0009987;cell-cell adhesion#GO:0098609;synaptic signaling#GO:0099536;protein localization to synapse#GO:0035418;multicellular organism development#GO:0007275 cell periphery#GO:0071944;basal plasma membrane#GO:0009925;neuron projection#GO:0043005;membrane#GO:0016020;basolateral plasma membrane#GO:0016323;plasma membrane#GO:0005886;neuron to neuron synapse#GO:0098984;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;synaptic membrane#GO:0097060;neuromuscular junction#GO:0031594;cell junction#GO:0030054;postsynapse#GO:0098794;basal part of cell#GO:0045178;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;synapse#GO:0045202;cellular anatomical structure#GO:0110165;asymmetric synapse#GO:0032279;organelle#GO:0043226;postsynaptic density#GO:0014069;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;postsynaptic density membrane#GO:0098839 scaffold/adaptor protein#PC00226 HUMAN|HGNC=24329|UniProtKB=Q9Y3A2 Q9Y3A2 UTP11 PTHR12838:SF0 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11-RELATED intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;preribosome#GO:0030684;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular organelle#GO:0043229;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;small-subunit processome#GO:0032040;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 RNA metabolism protein#PC00031 HUMAN|HGNC=6179|UniProtKB=P27987 P27987 ITPKB PTHR12400:SF4 INOSITOL POLYPHOSPHATE KINASE INOSITOL-TRISPHOSPHATE 3-KINASE B catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773 organophosphate metabolic process#GO:0019637;phosphorus metabolic process#GO:0006793;alcohol biosynthetic process#GO:0046165;cellular process#GO:0009987;small molecule metabolic process#GO:0044281;biosynthetic process#GO:0009058;metabolic process#GO:0008152;alcohol metabolic process#GO:0006066;small molecule biosynthetic process#GO:0044283;organophosphate biosynthetic process#GO:0090407 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 kinase#PC00137 HUMAN|HGNC=24878|UniProtKB=Q9BVK6 Q9BVK6 TMED9 PTHR22811:SF37 TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN 9 cargo adaptor activity#GO:0140312;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;vesicle budding from membrane#GO:0006900;vesicle organization#GO:0016050;intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;intracellular protein transport#GO:0006886;transport#GO:0006810;vesicle-mediated transport#GO:0016192;membrane organization#GO:0061024;endomembrane system organization#GO:0010256;macromolecule localization#GO:0033036;organelle organization#GO:0006996;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;localization#GO:0051179;cellular localization#GO:0051641;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;protein transport#GO:0015031;cellular component organization#GO:0016043;Golgi organization#GO:0007030 endomembrane system#GO:0012505;cytoplasm#GO:0005737;Golgi apparatus#GO:0005794;endoplasmic reticulum#GO:0005783;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;intracellular vesicle#GO:0097708;vesicle#GO:0031982;COPII-coated ER to Golgi transport vesicle#GO:0030134;cytoplasmic vesicle#GO:0031410;coated vesicle#GO:0030135;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 vesicle coat protein#PC00235;membrane traffic protein#PC00150 HUMAN|HGNC=19073|UniProtKB=Q8NI27 Q8NI27 THOC2 PTHR21597:SF0 THO2 PROTEIN THO COMPLEX SUBUNIT 2 RNA binding#GO:0003723;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488 nucleocytoplasmic transport#GO:0006913;nuclear export#GO:0051168;nuclear transport#GO:0051169;cellular localization#GO:0051641;mRNA export from nucleus#GO:0006406;nucleic acid transport#GO:0050657;localization#GO:0051179;mRNA transport#GO:0051028;establishment of RNA localization#GO:0051236;RNA localization#GO:0006403;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;transport#GO:0006810;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;metabolic process#GO:0008152;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;poly(A)+ mRNA export from nucleus#GO:0016973;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;nitrogen compound transport#GO:0071705;macromolecule localization#GO:0033036;biosynthetic process#GO:0009058;gene expression#GO:0010467 transcription export complex#GO:0000346;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;THO complex#GO:0000347;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 transcription cofactor#PC00217 HUMAN|HGNC=29229|UniProtKB=Q9ULI1 Q9ULI1 NWD2 PTHR19871:SF39 BETA TRANSDUCIN-RELATED PROTEIN NACHT AND WD REPEAT DOMAIN-CONTAINING PROTEIN 2 HUMAN|HGNC=8343|UniProtKB=O95221 O95221 OR5F1 PTHR26452:SF769 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5F1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 sensory perception of chemical stimulus#GO:0007606;sensory perception#GO:0007600;nervous system process#GO:0050877;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;system process#GO:0003008 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=13108|UniProtKB=P28698 P28698 MZF1 PTHR24384:SF2 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED MYELOID ZINC FINGER 1 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218 HUMAN|HGNC=670|UniProtKB=O00212 O00212 RHOD PTHR24072:SF175 RHO FAMILY GTPASE RHO-RELATED GTP-BINDING PROTEIN RHOD carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;kinase binding#GO:0019900;protein kinase binding#GO:0019901;guanyl nucleotide binding#GO:0019001;enzyme binding#GO:0019899;protein binding#GO:0005515;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;GTPase activity#GO:0003924;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;hydrolase activity#GO:0016787 cell communication#GO:0007154;supramolecular fiber organization#GO:0097435;actin filament-based process#GO:0030029;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;cell motility#GO:0048870;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;regulation of cytoskeleton organization#GO:0051493;signaling#GO:0023052;cellular component organization#GO:0016043;cellular response to stimulus#GO:0051716;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;actin filament organization#GO:0007015;regulation of actin filament-based process#GO:0032970;cell migration#GO:0016477;regulation of actin cytoskeleton organization#GO:0032956;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;organelle organization#GO:0006996;cellular process#GO:0009987;signal transduction#GO:0007165 cell periphery#GO:0071944;cytosol#GO:0005829;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 G-protein#PC00020;small GTPase#PC00208 HUMAN|HGNC=21186|UniProtKB=Q5SQI0 Q5SQI0 ATAT1 PTHR12327:SF0 ALPHA-TUBULIN N-ACETYLTRANSFERASE 1 ALPHA-TUBULIN N-ACETYLTRANSFERASE 1 acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;protein-lysine-acetyltransferase activity#GO:0061733;N-acetyltransferase activity#GO:0008080;protein N-acyltransferase activity#GO:0140186;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein N-acetyltransferase activity#GO:0034212;catalytic activity, acting on a protein#GO:0140096;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226;cytoskeleton organization#GO:0007010;microtubule-based process#GO:0007017;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987 HUMAN|HGNC=15804|UniProtKB=Q9BRP0 Q9BRP0 OVOL2 PTHR10032:SF193 ZINC FINGER PROTEIN WITH KRAB AND SCAN DOMAINS TRANSCRIPTION FACTOR OVO-LIKE 2 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;animal gross anatomical part developmental process#GO:0160108;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;developmental process#GO:0032502;epidermis development#GO:0008544;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;epithelium development#GO:0060429;regulation of nucleobase-containing compound metabolic process#GO:0019219;epidermal cell differentiation#GO:0009913;tissue development#GO:0009888;epithelial cell differentiation#GO:0030855;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=10304|UniProtKB=P40429 P40429 RPL13A PTHR11545:SF30 RIBOSOMAL PROTEIN L13 LARGE RIBOSOMAL SUBUNIT PROTEIN UL13 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;negative regulation of translation#GO:0017148;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of translation#GO:0006417;regulation of protein metabolic process#GO:0051246;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523 cytosol#GO:0005829;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625;ribosome#GO:0005840;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 translational protein#PC00263;ribosomal protein#PC00202 HUMAN|HGNC=33702|UniProtKB=Q5XKP0 Q5XKP0 MICOS13 PTHR31816:SF3 MICOS COMPLEX SUBUNIT MIC13 MICOS COMPLEX SUBUNIT MIC13 mitochondrial membrane organization#GO:0007006;cellular process#GO:0009987;inner mitochondrial membrane organization#GO:0007007;organelle organization#GO:0006996;cellular component organization#GO:0016043;membrane organization#GO:0061024;mitochondrion organization#GO:0007005;cellular component organization or biogenesis#GO:0071840 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;organelle membrane contact site#GO:0044232;membrane protein complex#GO:0098796;organelle envelope#GO:0031967;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrial membrane#GO:0031966;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;organelle membrane#GO:0031090;inner mitochondrial membrane protein complex#GO:0098800 HUMAN|HGNC=29007|UniProtKB=Q14CM0 Q14CM0 FRMPD4 PTHR46221:SF4 FERM AND PDZ DOMAIN-CONTAINING PROTEIN FAMILY MEMBER FERM AND PDZ DOMAIN-CONTAINING PROTEIN 4 lipid binding#GO:0008289;phosphatidylinositol bisphosphate binding#GO:1902936;binding#GO:0005488;small molecule binding#GO:0036094;anion binding#GO:0043168;phosphatidylinositol-4,5-bisphosphate binding#GO:0005546;ion binding#GO:0043167;phosphatidylinositol phosphate binding#GO:1901981;phospholipid binding#GO:0005543 postsynapse#GO:0098794;dendritic spine#GO:0043197;neuron projection#GO:0043005;synapse#GO:0045202;cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;neuron spine#GO:0044309;somatodendritic compartment#GO:0036477;cell projection#GO:0042995;dendrite#GO:0030425;dendritic tree#GO:0097447;cell junction#GO:0030054 HUMAN|HGNC=18650|UniProtKB=Q86XZ4 Q86XZ4 SPATS2 PTHR15623:SF10 SPERMATOGENESIS-ASSOCIATED SERINE-RICH PROTEIN 2-RELATED SPERMATOGENESIS-ASSOCIATED SERINE-RICH PROTEIN 2 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=30728|UniProtKB=O95478 O95478 NSA2 PTHR12642:SF3 RIBOSOME BIOGENESIS PROTEIN NSA2 HOMOLOG RIBOSOME BIOGENESIS PROTEIN NSA2 HOMOLOG cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;biosynthetic process#GO:0009058;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;maturation of LSU-rRNA#GO:0000470;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;ribosomal large subunit biogenesis#GO:0042273;ribonucleoprotein complex biogenesis#GO:0022613;maturation of 5.8S rRNA#GO:0000460;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466 membraneless organelle#GO:0043228;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;preribosome#GO:0030684;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;nucleolus#GO:0005730;intracellular organelle#GO:0043229;preribosome, large subunit precursor#GO:0030687;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=10329|UniProtKB=P46776 P46776 RPL27A PTHR11721:SF27 60S RIBOSOMAL PROTEIN L27A LARGE RIBOSOMAL SUBUNIT PROTEIN UL15 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;ribosome#GO:0005840;cytosol#GO:0005829;cytosolic large ribosomal subunit#GO:0022625;cytosolic ribosome#GO:0022626 translational protein#PC00263;ribosomal protein#PC00202 HUMAN|HGNC=9975|UniProtKB=P14373 P14373 TRIM27 PTHR24103:SF362 E3 UBIQUITIN-PROTEIN LIGASE TRIM ZINC FINGER PROTEIN RFP catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659 response to external biotic stimulus#GO:0043207;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;immune response#GO:0006955;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;response to other organism#GO:0051707;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of cellular process#GO:0048523;response to external stimulus#GO:0009605;regulation of gene expression#GO:0010468;defense response#GO:0006952;regulation of biosynthetic process#GO:0009889;innate immune response#GO:0045087;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;biological process involved in interspecies interaction between organisms#GO:0044419;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;immune system process#GO:0002376;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;defense response to symbiont#GO:0140546;negative regulation of macromolecule biosynthetic process#GO:0010558;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;defense response to other organism#GO:0098542;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=24225|UniProtKB=Q17RY6 Q17RY6 LY6K PTHR15049:SF1 GLYCOSYL-PHOSPHATIDYLINOSITOL-ANCHORED MOLECULE-LIKE PROTEIN-RELATED LYMPHOCYTE ANTIGEN 6K binding of sperm to zona pellucida#GO:0007339;cell-cell recognition#GO:0009988;sperm-egg recognition#GO:0035036;sexual reproduction#GO:0019953;cell recognition#GO:0008037;fertilization#GO:0009566;reproductive process#GO:0022414;single fertilization#GO:0007338;cellular process#GO:0009987 acrosomal vesicle#GO:0001669;intracellular organelle#GO:0043229;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular vesicle#GO:0097708;secretory vesicle#GO:0099503;vesicle#GO:0031982;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=28674|UniProtKB=Q9BSK0 Q9BSK0 MARVELD1 PTHR22776:SF28 MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN MARVEL DOMAIN-CONTAINING PROTEIN 1 regulation of biological process#GO:0050789;biological regulation#GO:0065007;signaling#GO:0023052 membrane#GO:0016020;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=2285|UniProtKB=P09669 P09669 COX6C PTHR48416:SF1 CYTOCHROME C OXIDASE SUBUNIT 6C CYTOCHROME C OXIDASE SUBUNIT 6C intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=8126|UniProtKB=P20774 P20774 OGN PTHR46269:SF1 EPIPHYCAN-RELATED MIMECAN tissue development#GO:0009888;multicellular organismal process#GO:0032501;bone development#GO:0060348;cartilage development#GO:0051216;connective tissue development#GO:0061448;system development#GO:0048731;anatomical structure development#GO:0048856;animal organ development#GO:0048513;multicellular organism development#GO:0007275;skeletal system development#GO:0001501;developmental process#GO:0032502;animal gross anatomical part developmental process#GO:0160108 cellular anatomical structure#GO:0110165;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576 HUMAN|HGNC=44438|UniProtKB=C9JJH3 C9JJH3 USP17L10 PTHR24006:SF651 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE INACTIVE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 17-LIKE PROTEIN 4-RELATED catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;cysteine-type deubiquitinase activity#GO:0004843;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity, acting on a protein#GO:0140096;deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787 regulation of apoptotic process#GO:0042981;regulation of protein stability#GO:0031647;regulation of biological process#GO:0050789;regulation of programmed cell death#GO:0043067;regulation of biological quality#GO:0065008;biological regulation#GO:0065007;regulation of cellular process#GO:0050794 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cytosol#GO:0005829;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 protease#PC00190;cysteine protease#PC00081 HUMAN|HGNC=30906|UniProtKB=O15195 O15195 VILL PTHR11977:SF30 VILLIN VILLIN-LIKE PROTEIN actin filament binding#GO:0051015;actin binding#GO:0003779;anion binding#GO:0043168;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;phosphatidylinositol-4,5-bisphosphate binding#GO:0005546;protein-containing complex binding#GO:0044877;lipid binding#GO:0008289;protein binding#GO:0005515;phosphatidylinositol bisphosphate binding#GO:1902936;cytoskeletal protein binding#GO:0008092;phospholipid binding#GO:0005543;phosphatidylinositol phosphate binding#GO:1901981 supramolecular fiber organization#GO:0097435;negative regulation of protein-containing complex assembly#GO:0031333;negative regulation of cytoskeleton organization#GO:0051494;negative regulation of protein-containing complex disassembly#GO:0043242;negative regulation of protein polymerization#GO:0032272;actin filament capping#GO:0051693;actin filament-based process#GO:0030029;regulation of actin filament depolymerization#GO:0030834;regulation of cytoskeleton organization#GO:0051493;negative regulation of supramolecular fiber organization#GO:1902904;regulation of protein polymerization#GO:0032271;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;regulation of supramolecular fiber organization#GO:1902903;negative regulation of organelle organization#GO:0010639;negative regulation of cellular component organization#GO:0051129;actin filament organization#GO:0007015;regulation of protein depolymerization#GO:1901879;negative regulation of cellular process#GO:0048523;regulation of actin filament-based process#GO:0032970;regulation of actin polymerization or depolymerization#GO:0008064;biological regulation#GO:0065007;negative regulation of protein depolymerization#GO:1901880;regulation of actin filament polymerization#GO:0030833;regulation of actin filament organization#GO:0110053;actin polymerization or depolymerization#GO:0008154;regulation of biological quality#GO:0065008;negative regulation of actin filament depolymerization#GO:0030835;regulation of actin filament length#GO:0030832;negative regulation of actin filament polymerization#GO:0030837;regulation of cellular component biogenesis#GO:0044087;regulation of cellular component organization#GO:0051128;regulation of biological process#GO:0050789;regulation of cellular component size#GO:0032535;regulation of organelle organization#GO:0033043;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;regulation of protein-containing complex assembly#GO:0043254;cellular component organization or biogenesis#GO:0071840;regulation of anatomical structure size#GO:0090066;cytoskeleton organization#GO:0007010;regulation of actin cytoskeleton organization#GO:0032956;cellular process#GO:0009987;regulation of protein-containing complex disassembly#GO:0043244;organelle organization#GO:0006996 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;actin cytoskeleton#GO:0015629 non-motor actin binding protein#PC00165;actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=9175|UniProtKB=P28340 P28340 POLD1 PTHR10322:SF23 DNA POLYMERASE CATALYTIC SUBUNIT DNA POLYMERASE DELTA CATALYTIC SUBUNIT DNA-directed DNA polymerase activity#GO:0003887;hydrolase activity#GO:0016787;DNA nuclease activity#GO:0004536;transferase activity, transferring phosphorus-containing groups#GO:0016772;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;nucleotidyltransferase activity#GO:0016779;3'-5'-DNA exonuclease activity#GO:0008296;nuclease activity#GO:0004518;DNA exonuclease activity, producing 5'-phosphomonoesters#GO:0016895;exonuclease activity#GO:0004527;3'-5' exonuclease activity#GO:0008408;DNA polymerase activity#GO:0034061;catalytic activity, acting on DNA#GO:0140097;DNA exonuclease activity#GO:0004529;transferase activity#GO:0016740 cellular process#GO:0009987;response to stress#GO:0006950;nucleobase-containing compound metabolic process#GO:0006139;nucleotide-excision repair#GO:0006289;DNA damage response#GO:0006974;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;macromolecule metabolic process#GO:0043170;DNA replication#GO:0006260;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;base-excision repair#GO:0006284;nucleic acid metabolic process#GO:0090304;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;DNA-templated DNA replication#GO:0006261 replication fork#GO:0005657;replisome#GO:0030894;chromosome#GO:0005694;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;protein-DNA complex#GO:0032993;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;nuclear replication fork#GO:0043596;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;protein-containing complex#GO:0032991;transferase complex#GO:1990234;DNA polymerase complex#GO:0042575;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513 DNA metabolism protein#PC00009 DNA replication#P00017>Pol delta#P00533 HUMAN|HGNC=26843|UniProtKB=Q502W7 Q502W7 CCDC38 PTHR21683:SF7 COILED-COIL DOMAIN-CONTAINING PROTEIN 42 LIKE-2-LIKE-RELATED COILED-COIL DOMAIN-CONTAINING PROTEIN 38 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;centrosome#GO:0005813;intracellular organelle#GO:0043229 non-motor microtubule binding protein#PC00166;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=28346|UniProtKB=Q96ND0 Q96ND0 MIMS1 PTHR21377:SF1 PROTEIN FAM210B, MITOCHONDRIAL MITOCHONDRIAL INNER MEMBRANE SCAFFOLD 1 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;organelle envelope#GO:0031967;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HUMAN|HGNC=22953|UniProtKB=Q8TB45 Q8TB45 DEPTOR PTHR22829:SF18 DEP DOMAIN PROTEIN DEP DOMAIN-CONTAINING MTOR-INTERACTING PROTEIN kinase inhibitor activity#GO:0019210;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;protein kinase regulator activity#GO:0019887;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;protein kinase inhibitor activity#GO:0004860;enzyme activator activity#GO:0008047;enzyme inhibitor activity#GO:0004857;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;molecular function activator activity#GO:0140677;guanyl-nucleotide exchange factor activity#GO:0005085 regulation of TORC1 signaling#GO:1903432;negative regulation of cellular process#GO:0048523;negative regulation of TORC1 signaling#GO:1904262;regulation of response to stimulus#GO:0048583;negative regulation of response to stimulus#GO:0048585;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of signal transduction#GO:0009968;signal transduction#GO:0007165;regulation of TOR signaling#GO:0032006;cellular process#GO:0009987;cell communication#GO:0007154;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;negative regulation of signaling#GO:0023057;G protein-coupled receptor signaling pathway#GO:0007186;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;negative regulation of TOR signaling#GO:0032007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of cell communication#GO:0010646;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein modulator#PC00022;protein-binding activity modulator#PC00095;guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=20092|UniProtKB=Q6VMQ6 Q6VMQ6 ATF7IP PTHR23210:SF22 ACTIVATING TRANSCRIPTION FACTOR 7 INTERACTING PROTEIN ACTIVATING TRANSCRIPTION FACTOR 7-INTERACTING PROTEIN 1 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HUMAN|HGNC=16809|UniProtKB=Q9HAU4 Q9HAU4 SMURF2 PTHR11254:SF300 HECT DOMAIN UBIQUITIN-PROTEIN LIGASE E3 UBIQUITIN-PROTEIN LIGASE SMURF2 catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;binding#GO:0005488;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;protein binding#GO:0005515 regulation of response to stimulus#GO:0048583;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;negative regulation of cellular process#GO:0048523;macromolecule catabolic process#GO:0009057;negative regulation of BMP signaling pathway#GO:0030514;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;regulation of BMP signaling pathway#GO:0030510;regulation of cellular response to growth factor stimulus#GO:0090287;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;proteasomal protein catabolic process#GO:0010498;negative regulation of response to stimulus#GO:0048585;protein catabolic process#GO:0030163;regulation of signaling#GO:0023051;modification-dependent macromolecule catabolic process#GO:0043632;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648;protein metabolic process#GO:0019538;modification-dependent protein catabolic process#GO:0019941;regulation of biological process#GO:0050789;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092;negative regulation of biological process#GO:0048519;primary metabolic process#GO:0044238;regulation of cell communication#GO:0010646;catabolic process#GO:0009056;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 TGF-beta signaling pathway#P00052>Smurfs#P01279;Ubiquitin proteasome pathway#P00060>E3#P01490 HUMAN|HGNC=1703|UniProtKB=Q01151 Q01151 CD83 PTHR15193:SF1 CD83 ANTIGEN CD83 ANTIGEN HUMAN|HGNC=19158|UniProtKB=Q9H8X9 Q9H8X9 ZDHHC11 PTHR22883:SF22 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE ZDHHC11-RELATED palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746 immune system process#GO:0002376;localization within membrane#GO:0051668;response to virus#GO:0009615;cellular localization#GO:0051641;localization#GO:0051179;defense response to virus#GO:0051607;antiviral innate immune response#GO:0140374;protein targeting#GO:0006605;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;protein targeting to membrane#GO:0006612;innate immune response#GO:0045087;establishment of localization#GO:0051234;defense response#GO:0006952;response to external stimulus#GO:0009605;response to stress#GO:0006950;establishment of protein localization to membrane#GO:0090150;response to biotic stimulus#GO:0009607;cellular process#GO:0009987;establishment of protein localization#GO:0045184;immune response#GO:0006955;defense response to symbiont#GO:0140546;defense response to other organism#GO:0098542;response to other organism#GO:0051707 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 protein modifying enzyme#PC00260 HUMAN|HGNC=18335|UniProtKB=Q8IY51 Q8IY51 TIGD4 PTHR19303:SF18 TRANSPOSON TIGGER TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4 nucleic acid binding#GO:0003676;binding#GO:0005488;DNA binding#GO:0003677 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 viral or transposable element protein#PC00237 HUMAN|HGNC=29131|UniProtKB=Q8IWE5 Q8IWE5 PLEKHM2 PTHR46556:SF1 PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY M MEMBER 2 PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY M MEMBER 2 protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;binding#GO:0005488 organelle localization#GO:0051640;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;regulation of localization#GO:0032879;regulation of protein localization#GO:0032880;organelle organization#GO:0006996;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;Golgi organization#GO:0007030;lysosome localization#GO:0032418;cellular process#GO:0009987;biological regulation#GO:0065007;endomembrane system organization#GO:0010256 bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane#GO:0016020;vesicle membrane#GO:0012506;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;endosome#GO:0005768;endosome membrane#GO:0010008;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=27257|UniProtKB=Q3MIP1 Q3MIP1 ITPRIPL2 PTHR10656:SF9 CELL FATE DETERMINING PROTEIN MAB21-RELATED INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR-INTERACTING PROTEIN-LIKE 2 transferase activity, transferring phosphorus-containing groups#GO:0016772;nucleotidyltransferase activity#GO:0016779;transferase activity#GO:0016740;catalytic activity#GO:0003824 transferase#PC00220;nucleotidyltransferase#PC00174 HUMAN|HGNC=10819|UniProtKB=O43765 O43765 SGTA PTHR45831:SF3 LD24721P SMALL GLUTAMINE-RICH TETRATRICOPEPTIDE REPEAT-CONTAINING PROTEIN ALPHA cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of protein localization to membrane#GO:0090150;establishment of protein localization to endoplasmic reticulum#GO:0072599;protein targeting#GO:0006605;post-translational protein targeting to endoplasmic reticulum membrane#GO:0006620;localization within membrane#GO:0051668;protein targeting to membrane#GO:0006612;protein targeting to ER#GO:0045047;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;establishment of protein localization to organelle#GO:0072594 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;membrane#GO:0016020;cytosol#GO:0005829 HUMAN|HGNC=7671|UniProtKB=Q13772 Q13772 NCOA4 PTHR17085:SF5 NUCLEAR RECEPTOR COACTIVATOR 4 NUCLEAR RECEPTOR COACTIVATOR 4 response to endogenous stimulus#GO:0009719;response to hormone#GO:0009725;response to stimulus#GO:0050896;response to chemical#GO:0042221 transcription cofactor#PC00217 HUMAN|HGNC=36809|UniProtKB=A0A8I5KQE6 A0A8I5KQE6 RPSA2 PTHR11489:SF17 40S RIBOSOMAL PROTEIN SA SMALL RIBOSOMAL SUBUNIT PROTEIN US2-RELATED structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular component assembly#GO:0022607;ribosomal small subunit biogenesis#GO:0042274;metabolic process#GO:0008152;protein-containing complex organization#GO:0043933;ribosomal small subunit assembly#GO:0000028;protein-RNA complex organization#GO:0071826;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;membraneless organelle assembly#GO:0140694;ribonucleoprotein complex biogenesis#GO:0022613;protein biosynthetic process#GO:0160307;cytoplasmic translation#GO:0002181;translation#GO:0006412;ribosome biogenesis#GO:0042254;ribosome assembly#GO:0042255;organelle assembly#GO:0070925;protein metabolic process#GO:0019538;protein-RNA complex assembly#GO:0022618 ribosome#GO:0005840;cytosol#GO:0005829;cytosolic ribosome#GO:0022626;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;small ribosomal subunit#GO:0015935;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;cytosolic small ribosomal subunit#GO:0022627;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 ribosomal protein#PC00202 HUMAN|HGNC=4126|UniProtKB=Q8N4A0 Q8N4A0 GALNT4 PTHR11675:SF7 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 4 polypeptide N-acetylgalactosaminyltransferase activity#GO:0004653;acetylgalactosaminyltransferase activity#GO:0008376;glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194;catalytic activity, acting on a protein#GO:0140096;hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;catalytic activity#GO:0003824 glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;carbohydrate derivative metabolic process#GO:1901135;protein O-linked glycosylation#GO:0006493;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 transferase#PC00220;glycosyltransferase#PC00111 HUMAN|HGNC=10784|UniProtKB=Q99590 Q99590 SCAF11 PTHR47048:SF1 PROTEIN SCAF11 PROTEIN SCAF11 protein-containing complex assembly#GO:0065003;mRNA splicing, via spliceosome#GO:0000398;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;ribonucleoprotein complex biogenesis#GO:0022613;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;spliceosomal complex assembly#GO:0000245;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA metabolic process#GO:0016070;protein-RNA complex assembly#GO:0022618;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;mRNA processing#GO:0006397;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular component assembly#GO:0022607;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;protein-containing complex organization#GO:0043933;protein-RNA complex organization#GO:0071826;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840 HUMAN|HGNC=19688|UniProtKB=Q96NY8 Q96NY8 NECTIN4 PTHR23277:SF11 NECTIN-RELATED NECTIN-4 binding#GO:0005488;cell adhesion molecule binding#GO:0050839;cell adhesion mediator activity#GO:0098631;protein binding#GO:0005515 cellular process#GO:0009987;heterophilic cell-cell adhesion#GO:0007157;cell adhesion#GO:0007155;cell-cell adhesion#GO:0098609;homophilic cell-cell adhesion#GO:0007156 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;cell-cell junction#GO:0005911;adherens junction#GO:0005912;anchoring junction#GO:0070161;cell junction#GO:0030054 cell adhesion molecule#PC00069 HUMAN|HGNC=4452|UniProtKB=O75487 O75487 GPC4 PTHR10822:SF25 GLYPICAN GLYPICAN-4 cell migration#GO:0016477;regulation of synapse assembly#GO:0051963;biological regulation#GO:0065007;cell-cell adhesion#GO:0098609;cellular process#GO:0009987;regulation of protein localization to membrane#GO:1905475;cellular component organization or biogenesis#GO:0071840;regulation of localization#GO:0032879;cell junction organization#GO:0034330;cell motility#GO:0048870;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of cellular component biogenesis#GO:0044087;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of synapse structure or activity#GO:0050803;regulation of biological quality#GO:0065008;regulation of protein localization#GO:0032880;synaptic membrane adhesion#GO:0099560;regulation of synapse organization#GO:0050807;regulation of cell junction assembly#GO:1901888;cell adhesion#GO:0007155;synapse organization#GO:0050808 cell surface#GO:0009986;cell junction#GO:0030054;cellular anatomical structure#GO:0110165;synapse#GO:0045202;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012 scaffold/adaptor protein#PC00226 HUMAN|HGNC=53846|UniProtKB=A0A1W2PRV1 A0A1W2PRV1 TAF11L3 PTHR13218:SF18 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11-RELATED TATA-BOX-BINDING PROTEIN-ASSOCIATED FACTOR 11-LIKE PROTEIN 10-RELATED protein-containing complex assembly#GO:0065003;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;nucleic acid metabolic process#GO:0090304;RNA polymerase II preinitiation complex assembly#GO:0051123;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;DNA-templated transcription initiation#GO:0006352;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;transcription initiation at RNA polymerase II promoter#GO:0006367;cellular component biogenesis#GO:0044085;protein-DNA complex assembly#GO:0065004;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular component assembly#GO:0022607;transcription by RNA polymerase II#GO:0006366;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;protein-containing complex organization#GO:0043933;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;protein-DNA complex organization#GO:0071824 intracellular protein-containing complex#GO:0140535;transcription regulator complex#GO:0005667;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234;transcription factor TFIID complex#GO:0005669;protein-containing complex#GO:0032991;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;membrane-enclosed lumen#GO:0031974;RNA polymerase II transcription regulator complex#GO:0090575;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;membrane-bounded organelle#GO:0043227;RNA polymerase II, holoenzyme#GO:0016591;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233 RNA metabolism protein#PC00031;general transcription factor#PC00259 HUMAN|HGNC=26669|UniProtKB=Q8NA47 Q8NA47 CCDC63 PTHR21694:SF18 COILED-COIL DOMAIN-CONTAINING PROTEIN 63 COILED-COIL DOMAIN-CONTAINING PROTEIN 63 HUMAN|HGNC=30365|UniProtKB=Q7L5Y1 Q7L5Y1 ENOSF1 PTHR13794:SF58 ENOLASE SUPERFAMILY, MANDELATE RACEMASE MITOCHONDRIAL ENOLASE SUPERFAMILY MEMBER 1 epimerase/racemase#PC00096 HUMAN|HGNC=16204|UniProtKB=Q9BQP9 Q9BQP9 BPIFA3 PTHR47736:SF1 BPI FOLD-CONTAINING FAMILY A MEMBER 3 BPI FOLD-CONTAINING FAMILY A MEMBER 3 HUMAN|HGNC=1386|UniProtKB=P57796 P57796 CABP4 PTHR45917:SF4 CALCIUM-BINDING PROTEIN 1-RELATED CALCIUM-BINDING PROTEIN 4 molecular function regulator activity#GO:0098772;channel regulator activity#GO:0016247;transporter regulator activity#GO:0141108;ion channel regulator activity#GO:0099106;calcium channel regulator activity#GO:0005246 nervous system process#GO:0050877;sensory perception of mechanical stimulus#GO:0050954;sensory perception#GO:0007600;cell communication#GO:0007154;response to abiotic stimulus#GO:0009628;sensory perception of light stimulus#GO:0050953;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;sensory perception of sound#GO:0007605;response to light stimulus#GO:0009416;visual perception#GO:0007601;signaling#GO:0023052;response to external stimulus#GO:0009605;system process#GO:0003008;detection of stimulus#GO:0051606;response to radiation#GO:0009314;cellular process#GO:0009987;signal transduction#GO:0007165;multicellular organismal process#GO:0032501;biological regulation#GO:0065007 HUMAN|HGNC=2231|UniProtKB=P53618 P53618 COPB1 PTHR10635:SF0 COATOMER SUBUNIT BETA COATOMER SUBUNIT BETA vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;intra-Golgi vesicle-mediated transport#GO:0006891;establishment of localization in cell#GO:0051649;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;intracellular transport#GO:0046907;transport#GO:0006810;Golgi vesicle transport#GO:0048193 Golgi-associated vesicle#GO:0005798;Golgi apparatus#GO:0005794;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane#GO:0016020;vesicle membrane#GO:0012506;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;COPI-coated vesicle#GO:0030137;cytoplasm#GO:0005737;vesicle coat#GO:0030120;intracellular organelle#GO:0043229;membrane coat#GO:0030117;coated membrane#GO:0048475;cytoplasmic vesicle#GO:0031410;coated vesicle#GO:0030135;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;vesicle#GO:0031982;COPI vesicle coat#GO:0030126;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;coated vesicle membrane#GO:0030662;Golgi-associated vesicle membrane#GO:0030660 vesicle coat protein#PC00235 HUMAN|HGNC=6780|UniProtKB=Q9ULX9 Q9ULX9 MAFF PTHR10129:SF25 TRANSCRIPTION FACTOR MAF TRANSCRIPTION FACTOR MAFF transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of developmental process#GO:0050793;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of multicellular organismal development#GO:2000026;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of multicellular organismal process#GO:0051239;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of primary metabolic process#GO:0080090;regulation of epithelial cell differentiation#GO:0030856;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of cell differentiation#GO:0045595 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;basic leucine zipper transcription factor#PC00056 HUMAN|HGNC=32443|UniProtKB=Q8N967 Q8N967 LRTM2 PTHR24369:SF221 ANTIGEN BSP, PUTATIVE-RELATED LEUCINE-RICH REPEAT AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 2 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 cell adhesion molecule#PC00069 HUMAN|HGNC=15549|UniProtKB=Q96KS9 Q96KS9 FAM167A PTHR32289:SF3 PROTEIN FAM167A PROTEIN FAM167A HUMAN|HGNC=14304|UniProtKB=Q8IWX7 Q8IWX7 UNC45B PTHR45994:SF2 FI21225P1 PROTEIN UNC-45 HOMOLOG B heat shock protein binding#GO:0031072;Hsp90 protein binding#GO:0051879;binding#GO:0005488;protein binding#GO:0005515 gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;protein folding#GO:0006457;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=31418|UniProtKB=Q5VYM1 Q5VYM1 SPATA31G1 PTHR21777:SF0 RCG55159-LIKE SPERMATOGENESIS-ASSOCIATED PROTEIN 31G1 HUMAN|HGNC=21102|UniProtKB=Q8WV19 Q8WV19 SFT2D1 PTHR23137:SF24 VESICLE TRANSPORT PROTEIN-RELATED VESICLE TRANSPORT PROTEIN SFT2A HUMAN|HGNC=19367|UniProtKB=O94988 O94988 FAM13A PTHR15904:SF18 FAM13 PROTEIN FAM13A HUMAN|HGNC=14108|UniProtKB=Q9UIA9 Q9UIA9 XPO7 PTHR12596:SF11 EXPORTIN 4,7-RELATED EXPORTIN-7 molecular carrier activity#GO:0140104;nucleocytoplasmic carrier activity#GO:0140142 establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810;protein export from nucleus#GO:0006611;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular localization#GO:0051641;localization#GO:0051179;nuclear export#GO:0051168;protein transport#GO:0015031;nuclear transport#GO:0051169;nucleocytoplasmic transport#GO:0006913 organelle envelope#GO:0031967;nucleus#GO:0005634;organelle#GO:0043226;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;nuclear pore#GO:0005643;intracellular anatomical structure#GO:0005622 transporter#PC00227 HUMAN|HGNC=24637|UniProtKB=Q8IXB1 Q8IXB1 DNAJC10 PTHR44340:SF1 DNAJ HOMOLOG SUBFAMILY C MEMBER 10 ENDOPLASMIC RETICULUM DISULFIDE REDUCTASE DNAJC10 protein binding#GO:0005515;protein-disulfide reductase activity#GO:0015035;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;binding#GO:0005488;disulfide oxidoreductase activity#GO:0015036;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 response to endoplasmic reticulum stress#GO:0034976;cellular response to unfolded protein#GO:0034620;cellular response to topologically incorrect protein#GO:0035967;cellular response to stress#GO:0033554;cell communication#GO:0007154;response to unfolded protein#GO:0006986;intracellular signal transduction#GO:0035556;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;response to topologically incorrect protein#GO:0035966;signaling#GO:0023052;response to stress#GO:0006950;endoplasmic reticulum unfolded protein response#GO:0030968;cellular process#GO:0009987;signal transduction#GO:0007165;biological regulation#GO:0065007 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;endoplasmic reticulum lumen#GO:0005788;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 chaperone#PC00072 HUMAN|HGNC=10313|UniProtKB=P46778 P46778 RPL21 PTHR20981:SF8 60S RIBOSOMAL PROTEIN L21 LARGE RIBOSOMAL SUBUNIT PROTEIN EL21 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 cytosolic large ribosomal subunit#GO:0022625;cytosolic ribosome#GO:0022626;cytosol#GO:0005829;ribosome#GO:0005840;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202 HUMAN|HGNC=12442|UniProtKB=P14679 P14679 TYR PTHR11474:SF124 TYROSINASE FAMILY MEMBER TYROSINASE oxidoreductase activity#GO:0016491;monooxygenase activity#GO:0004497;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705 secondary metabolic process#GO:0019748;melanin biosynthetic process#GO:0042438;pigment biosynthetic process#GO:0046148;metabolic process#GO:0008152;secondary metabolite biosynthetic process#GO:0044550;biosynthetic process#GO:0009058;phenol-containing compound metabolic process#GO:0018958;cellular process#GO:0009987;phenol-containing compound biosynthetic process#GO:0046189;pigment metabolic process#GO:0042440 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;melanosome#GO:0042470 oxygenase#PC00177 HUMAN|HGNC=2015|UniProtKB=A8K7I4 A8K7I4 CLCA1 PTHR10579:SF52 CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR 1 gated channel activity#GO:0022836;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic anion channel activity#GO:0005253;channel activity#GO:0015267;chloride transmembrane transporter activity#GO:0015108;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;chloride channel activity#GO:0005254;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic anion transmembrane transporter activity#GO:0008509;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 ion channel#PC00133 HUMAN|HGNC=82|UniProtKB=P09110 P09110 ACAA1 PTHR43853:SF8 3-KETOACYL-COA THIOLASE, PEROXISOMAL 3-KETOACYL-COA THIOLASE, PEROXISOMAL acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 monocarboxylic acid catabolic process#GO:0072329;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;lipid catabolic process#GO:0016042;lipid modification#GO:0030258;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;fatty acid beta-oxidation#GO:0006635;fatty acid oxidation#GO:0019395;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;small molecule catabolic process#GO:0044282;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;lipid oxidation#GO:0034440;fatty acid catabolic process#GO:0009062;oxoacid metabolic process#GO:0043436 peroxisome#GO:0005777;microbody#GO:0042579;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 acetyltransferase#PC00038 HUMAN|HGNC=19681|UniProtKB=Q9UII6 Q9UII6 DUSP13B PTHR45682:SF10 AGAP008228-PA DUAL SPECIFICITY PROTEIN PHOSPHATASE 13B phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;protein tyrosine/serine/threonine phosphatase activity#GO:0008138;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787 regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;negative regulation of MAPK cascade#GO:0043409;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of MAPK cascade#GO:0043408;negative regulation of response to stimulus#GO:0048585;negative regulation of signal transduction#GO:0009968;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 protein phosphatase#PC00195 Oxidative stress response#P00046>MKP5#P01131 HUMAN|HGNC=14544|UniProtKB=Q96J92 Q96J92 WNK4 PTHR13902:SF114 SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED SERINE_THREONINE-PROTEIN KINASE WNK4 phosphotransferase activity, alcohol group as acceptor#GO:0016773;molecular function inhibitor activity#GO:0140678;protein kinase activity#GO:0004672;channel regulator activity#GO:0016247;protein serine/threonine kinase activity#GO:0004674;transporter regulator activity#GO:0141108;potassium channel regulator activity#GO:0015459;catalytic activity, acting on a protein#GO:0140096;molecular function regulator activity#GO:0098772;catalytic activity#GO:0003824;transferase activity#GO:0016740;ion channel regulator activity#GO:0099106;ion channel inhibitor activity#GO:0008200;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;homeostatic process#GO:0042592;signaling#GO:0023052;regulation of cellular process#GO:0050794;regulation of metal ion transport#GO:0010959;response to stimulus#GO:0050896;negative regulation of transport#GO:0051051;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of transmembrane transport#GO:0034762;negative regulation of biological process#GO:0048519;regulation of transport#GO:0051049;regulation of localization#GO:0032879;chemical homeostasis#GO:0048878;regulation of monoatomic cation transmembrane transport#GO:1904062;biological regulation#GO:0065007;regulation of monoatomic ion transport#GO:0043269;regulation of monoatomic ion transmembrane transport#GO:0034765;cellular process#GO:0009987;positive regulation of transport#GO:0051050;positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;monoatomic ion homeostasis#GO:0050801 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=21485|UniProtKB=Q96NH3 Q96NH3 TBC1D32 PTHR13465:SF3 UPF0183 PROTEIN PROTEIN BROAD-MINDED plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cell projection organization#GO:0030030;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component organization#GO:0016043;cilium assembly#GO:0060271;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cilium organization#GO:0044782;non-motile cilium assembly#GO:1905515;cellular component organization or biogenesis#GO:0071840;organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031 HUMAN|HGNC=11168|UniProtKB=Q13884 Q13884 SNTB1 PTHR10554:SF11 SYNTROPHIN BETA-1-SYNTROPHIN plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;synapse#GO:0045202;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;dystrophin-associated glycoprotein complex#GO:0016010;membrane#GO:0016020;membrane protein complex#GO:0098796;cell junction#GO:0030054 scaffold/adaptor protein#PC00226 HUMAN|HGNC=10895|UniProtKB=O75351 O75351 VPS4B PTHR23074:SF72 AAA DOMAIN-CONTAINING VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4B ATP hydrolysis activity#GO:0016887;hydrolase activity#GO:0016787;ATP-dependent activity#GO:0140657;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462 catabolic process#GO:0009056;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;protein metabolic process#GO:0019538;cellular localization#GO:0051641;localization#GO:0051179;vacuole organization#GO:0007033;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043162;vesicle-mediated transport#GO:0016192;endosome transport via multivesicular body sorting pathway#GO:0032509;organelle organization#GO:0006996;multivesicular body sorting pathway#GO:0071985;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;ubiquitin-dependent protein catabolic process#GO:0006511;endosomal transport#GO:0016197;intracellular transport#GO:0046907;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;transport#GO:0006810 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;intracellular organelle#GO:0043229 microtubule or microtubule-binding cytoskeletal protein#PC00157;non-motor microtubule binding protein#PC00166 HUMAN|HGNC=26295|UniProtKB=Q68D86 Q68D86 CCDC102B PTHR46292:SF2 COILED-COIL DOMAIN-CONTAINING PROTEIN 102A COILED-COIL DOMAIN-CONTAINING PROTEIN 102B HUMAN|HGNC=9030|UniProtKB=P04054 P04054 PLA2G1B PTHR11716:SF94 PHOSPHOLIPASE A2 FAMILY MEMBER PHOSPHOLIPASE A2 hydrolase activity, acting on ester bonds#GO:0016788;phospholipid binding#GO:0005543;catalytic activity#GO:0003824;cation binding#GO:0043169;hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689;ion binding#GO:0043167;signaling receptor binding#GO:0005102;small molecule binding#GO:0036094;lipase activity#GO:0016298;A2-type glycerophospholipase activity#GO:0004623;phospholipase activity#GO:0120569;glycerophospholipase activity#GO:0004620;lipid binding#GO:0008289;protein binding#GO:0005515;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;binding#GO:0005488 lipid metabolic process#GO:0006629;metabolic process#GO:0008152;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phospholipid metabolic process#GO:0006644;phosphatidylglycerol metabolic process#GO:0046471;glycerophospholipid metabolic process#GO:0006650;phosphatidylcholine metabolic process#GO:0046470;glycerolipid metabolic process#GO:0046486 phospholipase#PC00186 HUMAN|HGNC=29150|UniProtKB=Q9Y2E4 Q9Y2E4 DIP2C PTHR22754:SF33 DISCO-INTERACTING PROTEIN 2 DIP2 -RELATED DISCO-INTERACTING PROTEIN 2 HOMOLOG C catalytic activity#GO:0003824;ligase activity, forming carbon-sulfur bonds#GO:0016877;ligase activity#GO:0016874 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HUMAN|HGNC=8050|UniProtKB=O95989 O95989 NUDT3 PTHR12629:SF5 DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE 1 hydrolase activity#GO:0016787;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817 nucleobase-containing compound metabolic process#GO:0006139;organophosphate metabolic process#GO:0019637;nucleobase-containing compound catabolic process#GO:0034655;cellular process#GO:0009987;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;alcohol metabolic process#GO:0006066;nucleotide catabolic process#GO:0009166;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;nucleoside phosphate catabolic process#GO:1901292;small molecule catabolic process#GO:0044282;nucleoside phosphate metabolic process#GO:0006753;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;nucleotide metabolic process#GO:0009117;organophosphate catabolic process#GO:0046434 nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 phosphatase#PC00181 HUMAN|HGNC=18916|UniProtKB=A8MUX0 A8MUX0 KRTAP16-1 PTHR23262:SF55 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 16-1 structural protein#PC00211 HUMAN|HGNC=13112|UniProtKB=P24278 P24278 ZBTB25 PTHR24399:SF28 ZINC FINGER AND BTB DOMAIN-CONTAINING ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 25 RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription repressor activity#GO:0001217;transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565 negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of cytokine production#GO:0001817;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=13229|UniProtKB=Q96KV6 Q96KV6 BTN2A3P PTHR24100:SF110 BUTYROPHILIN BUTYROPHILIN SUBFAMILY 2 MEMBER A3-RELATED signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515 cell communication#GO:0007154;regulation of immune response#GO:0050776;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;immune response-activating cell surface receptor signaling pathway#GO:0002429;cellular response to stimulus#GO:0051716;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;T cell receptor signaling pathway#GO:0050852;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cytokine production#GO:0001817;immune system process#GO:0002376;response to stimulus#GO:0050896;signaling#GO:0023052;immune response-regulating signaling pathway#GO:0002764;regulation of biological process#GO:0050789;immune response-activating signaling pathway#GO:0002757;cell surface receptor signaling pathway#GO:0007166;antigen receptor-mediated signaling pathway#GO:0050851;regulation of multicellular organismal process#GO:0051239;positive regulation of immune system process#GO:0002684;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253 membrane#GO:0016020;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=30307|UniProtKB=O00124 O00124 UBXN8 PTHR23322:SF109 FAS-ASSOCIATED PROTEIN UBX DOMAIN-CONTAINING PROTEIN 8 ubiquitin binding#GO:0043130;binding#GO:0005488;protein binding#GO:0005515 ERAD pathway#GO:0036503;protein metabolic process#GO:0019538;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;response to endoplasmic reticulum stress#GO:0034976;response to stimulus#GO:0050896;catabolic process#GO:0009056;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasomal protein catabolic process#GO:0010498;response to chemical#GO:0042221;cellular process#GO:0009987;response to stress#GO:0006950 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=18275|UniProtKB=Q969K4 Q969K4 ABTB1 PTHR46231:SF1 ANKYRIN REPEAT AND BTB/POZ DOMAIN-CONTAINING PROTEIN 1 ANKYRIN REPEAT AND BTB_POZ DOMAIN-CONTAINING PROTEIN 1 intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;transferase complex#GO:1990234;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 HUMAN|HGNC=25920|UniProtKB=Q8NCJ5 Q8NCJ5 SPRYD3 PTHR12864:SF89 RAN BINDING PROTEIN 9-RELATED SPRY DOMAIN-CONTAINING PROTEIN 3 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 scaffold/adaptor protein#PC00226 HUMAN|HGNC=14955|UniProtKB=Q9NPC7 Q9NPC7 MYNN PTHR23226:SF170 ZINC FINGER AND SCAN DOMAIN-CONTAINING MYONEURIN transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=11577|UniProtKB=Q16635 Q16635 TAFAZZIN PTHR12497:SF8 TAZ PROTEIN TAFAZZIN TAFAZZIN transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;cellular component organization#GO:0016043;phosphatidylglycerol metabolic process#GO:0046471;glycerolipid metabolic process#GO:0046486;phospholipid metabolic process#GO:0006644;organophosphate metabolic process#GO:0019637;organelle organization#GO:0006996;mitochondrial membrane organization#GO:0007006;inner mitochondrial membrane organization#GO:0007007;cellular process#GO:0009987;glycerophospholipid metabolic process#GO:0006650;mitochondrion organization#GO:0007005;membrane organization#GO:0061024;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;cellular component organization or biogenesis#GO:0071840 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 acyltransferase#PC00042 HUMAN|HGNC=25366|UniProtKB=Q5T0J7 Q5T0J7 TEX35 PTHR36860:SF1 TESTIS-EXPRESSED PROTEIN 35 TESTIS-EXPRESSED PROTEIN 35 HUMAN|HGNC=13813|UniProtKB=Q9BWU0 Q9BWU0 SLC4A1AP PTHR23308:SF66 NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1 KANADAPTIN molecular function regulator activity#GO:0098772;molecular function inhibitor activity#GO:0140678 RNA splicing factor#PC00148 HUMAN|HGNC=2918|UniProtKB=P56178 P56178 DLX5 PTHR24327:SF31 HOMEOBOX PROTEIN HOMEOBOX PROTEIN DLX-5 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;embryo development#GO:0009790;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;developmental process#GO:0032502;regulation of gene expression#GO:0010468;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;embryo development ending in birth or egg hatching#GO:0009792;chordate embryonic development#GO:0043009;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;skeletal system development#GO:0001501;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355 gene-specific transcriptional regulator#PC00264;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=15717|UniProtKB=P57678 P57678 GEMIN4 PTHR15571:SF2 GEM-ASSOCIATED PROTEIN 4 GEM-ASSOCIATED PROTEIN 4 RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;protein-RNA complex assembly#GO:0022618;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;protein-containing complex assembly#GO:0065003;spliceosomal snRNP assembly#GO:0000387;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;ribonucleoprotein complex biogenesis#GO:0022613;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-RNA complex organization#GO:0071826;protein-containing complex organization#GO:0043933;mRNA processing#GO:0006397;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component assembly#GO:0022607;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396 intracellular anatomical structure#GO:0005622;SMN-Sm protein complex#GO:0034719;membrane-bounded organelle#GO:0043227;SMN complex#GO:0032797;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;organelle lumen#GO:0043233;membraneless organelle#GO:0043228;Sm-like protein family complex#GO:0120114;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974 HUMAN|HGNC=14791|UniProtKB=Q8NGH8 Q8NGH8 OR56A4 PTHR26450:SF424 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 56A4 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=24576|UniProtKB=Q9H211 Q9H211 CDT1 PTHR28637:SF1 DNA REPLICATION FACTOR CDT1 DNA REPLICATION FACTOR CDT1 enzyme binding#GO:0019899;nucleic acid binding#GO:0003676;binding#GO:0005488;protein binding#GO:0005515;DNA binding#GO:0003677 negative regulation of cell cycle#GO:0045786;DNA replication checkpoint signaling#GO:0000076;negative regulation of cellular process#GO:0048523;negative regulation of cell cycle process#GO:0010948;regulation of nucleobase-containing compound metabolic process#GO:0019219;cell cycle checkpoint signaling#GO:0000075;regulation of DNA-templated DNA replication initiation#GO:0030174;regulation of cell cycle process#GO:0010564;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;DNA integrity checkpoint signaling#GO:0031570;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;signal transduction#GO:0007165;cell communication#GO:0007154;regulation of DNA replication#GO:0006275;intracellular signal transduction#GO:0035556;regulation of cellular process#GO:0050794;mitotic cell cycle#GO:0000278;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;regulation of cell cycle#GO:0051726;signaling#GO:0023052;negative regulation of cell cycle phase transition#GO:1901988;regulation of cell cycle phase transition#GO:1901987;negative regulation of biological process#GO:0048519;cell cycle#GO:0007049;cellular response to stimulus#GO:0051716;regulation of DNA-templated DNA replication#GO:0090329;regulation of DNA metabolic process#GO:0051052;regulation of biological process#GO:0050789 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 DNA metabolism protein#PC00009 HUMAN|HGNC=15828|UniProtKB=Q9Y272 Q9Y272 RASD1 PTHR46149:SF4 MIP08469P DEXAMETHASONE-INDUCED RAS-RELATED PROTEIN 1 protein binding#GO:0005515;binding#GO:0005488 cell communication#GO:0007154;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=29383|UniProtKB=Q8NCY6 Q8NCY6 MSANTD4 PTHR21732:SF0 MYB/SANT-LIKE DNA-BINDING DOMAIN-CONTAINING PROTEIN 4 MYB_SANT-LIKE DNA-BINDING DOMAIN-CONTAINING PROTEIN 4 HUMAN|HGNC=26944|UniProtKB=Q9NPI0 Q9NPI0 TMEM138 PTHR13306:SF6 TRANSMEMBRANE PROTEIN 138 TRANSMEMBRANE PROTEIN 138 cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782;plasma membrane bounded cell projection assembly#GO:0120031;organelle assembly#GO:0070925;cellular component assembly#GO:0022607;cell projection organization#GO:0030030;plasma membrane bounded cell projection organization#GO:0120036;cilium assembly#GO:0060271;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cell projection assembly#GO:0030031 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;membrane-bounded organelle#GO:0043227;plasma membrane bounded cell projection#GO:0120025;cilium#GO:0005929 HUMAN|HGNC=23472|UniProtKB=Q96A46 Q96A46 SLC25A28 PTHR45758:SF20 MITOFERRIN-1-RELATED MITOFERRIN-2 metal ion transmembrane transporter activity#GO:0046873;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075;iron ion transmembrane transporter activity#GO:0005381;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;transition metal ion transmembrane transporter activity#GO:0046915 transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;transition metal ion transport#GO:0000041;transport#GO:0006810;iron ion transport#GO:0006826;iron ion transmembrane transport#GO:0034755;monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;cellular process#GO:0009987 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;membrane#GO:0016020;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740 HUMAN|HGNC=101|UniProtKB=Q9UHC3 Q9UHC3 ASIC3 PTHR11690:SF228 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED ACID-SENSING ION CHANNEL 3 sodium channel activity#GO:0005272;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;ligand-gated monoatomic cation channel activity#GO:0099094;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324 monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;monoatomic ion transmembrane transport#GO:0034220;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;sodium ion transport#GO:0006814;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133;transporter#PC00227 HUMAN|HGNC=22207|UniProtKB=Q9UPZ6 Q9UPZ6 THSD7A PTHR11311:SF8 SPONDIN THROMBOSPONDIN TYPE-1 DOMAIN-CONTAINING PROTEIN 7A cellular component organization#GO:0016043;organelle organization#GO:0006996;actin filament-based process#GO:0030029;cellular process#GO:0009987;actin cytoskeleton organization#GO:0030036;cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 cell adhesion molecule#PC00069 HUMAN|HGNC=23216|UniProtKB=Q96JG9 Q96JG9 ZNF469 PTHR21465:SF2 ZINC FINGER PROTEIN 469 ZINC FINGER PROTEIN 469 HUMAN|HGNC=17895|UniProtKB=Q16763 Q16763 UBE2S PTHR24068:SF126 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2 S ubiquitin-like protein conjugating enzyme activity#GO:0061650;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin conjugating enzyme activity#GO:0061631;transferase activity#GO:0016740;catalytic activity#GO:0003824 metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein modification by small protein conjugation or removal#GO:0070647;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;protein polyubiquitination#GO:0000209;protein modification process#GO:0036211;primary metabolic process#GO:0044238;catabolic process#GO:0009056 ubiquitin-protein ligase#PC00234 Ubiquitin proteasome pathway#P00060>E2#P01491 HUMAN|HGNC=23214|UniProtKB=Q9UPT5 Q9UPT5 EXOC7 PTHR12542:SF41 EXOCYST COMPLEX PROTEIN EXO70 EXOCYST COMPLEX COMPONENT 7 transport#GO:0006810;secretion by cell#GO:0032940;exocytosis#GO:0006887;localization#GO:0051179;establishment of localization#GO:0051234;secretion#GO:0046903;cellular process#GO:0009987;export from cell#GO:0140352;vesicle-mediated transport#GO:0016192 exocyst#GO:0000145;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cell cortex#GO:0005938;cell periphery#GO:0071944;vesicle tethering complex#GO:0099023;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HUMAN|HGNC=4833|UniProtKB=P09105 P09105 HBQ1 PTHR11442:SF15 HEMOGLOBIN FAMILY MEMBER HEMOGLOBIN SUBUNIT THETA-1 heme binding#GO:0020037;molecular carrier activity#GO:0140104;binding#GO:0005488;tetrapyrrole binding#GO:0046906 establishment of localization#GO:0051234;cellular developmental process#GO:0048869;multicellular organismal-level homeostasis#GO:0048871;developmental process#GO:0032502;transport#GO:0006810;multicellular organismal process#GO:0032501;hemopoiesis#GO:0030097;cellular process#GO:0009987;localization#GO:0051179;anatomical structure development#GO:0048856;erythrocyte differentiation#GO:0030218;immune system process#GO:0002376;homeostasis of number of cells#GO:0048872;cell differentiation#GO:0030154;myeloid cell differentiation#GO:0030099;homeostatic process#GO:0042592;cell development#GO:0048468 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 transfer/carrier protein#PC00219;globin#PC00107 HUMAN|HGNC=11469|UniProtKB=O00267 O00267 SUPT5H PTHR11125:SF7 SUPPRESSOR OF TY 5 TRANSCRIPTION ELONGATION FACTOR SPT5 nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;RNA binding#GO:0003723 nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;transcription by RNA polymerase II#GO:0006366;macromolecule metabolic process#GO:0043170;DNA-templated transcription elongation#GO:0006354;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;transcription elongation by RNA polymerase II#GO:0006368;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774 protein-containing complex#GO:0032991;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;transcription elongation factor complex#GO:0008023;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 HUMAN|HGNC=15201|UniProtKB=Q9H344 Q9H344 OR51I2 PTHR26450:SF112 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 51I2 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=25014|UniProtKB=Q9P000 Q9P000 COMMD9 PTHR15663:SF4 COMM DOMAIN-CONTAINING PROTEIN 9 COMM DOMAIN-CONTAINING PROTEIN 9 protein complex scaffold activity#GO:0140378;structural molecule activity#GO:0005198 protein-containing complex#GO:0032991 HUMAN|HGNC=3806|UniProtKB=O00358 O00358 FOXE1 PTHR11829:SF368 FORKHEAD BOX PROTEIN FORKHEAD BOX PROTEIN E1 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;regulation of RNA metabolic process#GO:0051252;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;developmental process#GO:0032502 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 helix-turn-helix transcription factor#PC00116;gene-specific transcriptional regulator#PC00264;winged helix/forkhead transcription factor#PC00246 HUMAN|HGNC=11441|UniProtKB=O43752 O43752 STX6 PTHR19957:SF104 SYNTAXIN SYNTAXIN-6 SNAP receptor activity#GO:0005484;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 intracellular transport#GO:0046907;transport#GO:0006810;intracellular protein transport#GO:0006886;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;endosomal transport#GO:0016197;vesicle organization#GO:0016050;membrane fusion#GO:0061025;retrograde transport, endosome to Golgi#GO:0042147;organelle organization#GO:0006996;macromolecule localization#GO:0033036;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;organelle fusion#GO:0048284;vesicle-mediated transport#GO:0016192;membrane organization#GO:0061024;organelle membrane fusion#GO:0090174;localization#GO:0051179;cellular localization#GO:0051641;protein transport#GO:0015031;cellular component organization#GO:0016043;vesicle fusion#GO:0006906;cytosolic transport#GO:0016482 membrane#GO:0016020;secretory vesicle#GO:0099503;vesicle membrane#GO:0012506;presynapse#GO:0098793;protein-containing complex#GO:0032991;transport vesicle membrane#GO:0030658;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;transport vesicle#GO:0030133;cytoplasm#GO:0005737;cell junction#GO:0030054;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;synaptic vesicle#GO:0008021;vesicle#GO:0031982;synaptic vesicle membrane#GO:0030672;SNARE complex#GO:0031201;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227 SNARE protein#PC00034 Alpha adrenergic receptor signaling pathway#P00002>SNARE#P00074 HUMAN|HGNC=14107|UniProtKB=Q969W9 Q969W9 PMEPA1 PTHR16514:SF5 LOW DENSITY LIPOPROTEIN RECEPTOR CLASS A DOMAIN-CONTAINING 4A PROTEIN TMEPAI protein binding#GO:0005515;binding#GO:0005488 negative regulation of biological process#GO:0048519;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092;regulation of transforming growth factor beta receptor signaling pathway#GO:0017015;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;negative regulation of cell communication#GO:0010648;negative regulation of response to stimulus#GO:0048585;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cellular response to growth factor stimulus#GO:0090287;negative regulation of signal transduction#GO:0009968;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583 endosome membrane#GO:0010008;endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;early endosome#GO:0005769;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;early endosome membrane#GO:0031901;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane#GO:0016020;vesicle membrane#GO:0012506;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737 HUMAN|HGNC=28789|UniProtKB=Q96BY9 Q96BY9 SARAF PTHR15929:SF0 STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR regulation of metal ion transport#GO:0010959;regulation of monoatomic ion transport#GO:0043269;biological regulation#GO:0065007;regulation of calcium ion transport#GO:0051924;regulation of transport#GO:0051049;regulation of localization#GO:0032879;regulation of biological process#GO:0050789 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;membrane#GO:0016020;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 HUMAN|HGNC=16631|UniProtKB=P82909 P82909 KGD4 PTHR31601:SF3 28S RIBOSOMAL PROTEIN S36, MITOCHONDRIAL ALPHA-KETOGLUTARATE DEHYDROGENASE COMPONENT 4 cellular process#GO:0009987;carboxylic acid metabolic process#GO:0019752;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;transferase complex#GO:1990234;catalytic complex#GO:1902494;oxidoreductase complex#GO:1990204 ribosomal protein#PC00202;translational protein#PC00263 HUMAN|HGNC=15973|UniProtKB=Q86UW9 Q86UW9 DTX2 PTHR12622:SF21 DELTEX-RELATED E3 UBIQUITIN-PROTEIN LIGASE DTX2-RELATED aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746 primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;modification-dependent protein catabolic process#GO:0019941;cellular response to stimulus#GO:0051716;catabolic process#GO:0009056;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;cell communication#GO:0007154;protein metabolic process#GO:0019538;signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;proteasomal protein catabolic process#GO:0010498;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;cell surface receptor signaling pathway#GO:0007166;macromolecule metabolic process#GO:0043170;Notch signaling pathway#GO:0007219;ubiquitin-dependent protein catabolic process#GO:0006511 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=17278|UniProtKB=Q12796 Q12796 PNRC1 PTHR15405:SF4 PROLINE-RICH NUCLEAR RECEPTOR COACTIVATOR PROLINE-RICH NUCLEAR RECEPTOR COACTIVATOR 1 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=4383|UniProtKB=P30679 P30679 GNA15 PTHR10218:SF217 GTP-BINDING PROTEIN ALPHA SUBUNIT GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15 GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity#GO:0016787;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817;molecular function regulator activity#GO:0098772;ribonucleoside triphosphate phosphatase activity#GO:0017111 response to oxygen-containing compound#GO:1901700;phospholipase C-activating G protein-coupled receptor signaling pathway#GO:0007200;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;response to nitrogen compound#GO:1901698;regulation of biological quality#GO:0065008;cell communication#GO:0007154;action potential#GO:0001508;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;regulation of membrane potential#GO:0042391;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;cellular process#GO:0009987;G protein-coupled dopamine receptor signaling pathway#GO:0007212;biological regulation#GO:0065007;response to chemical#GO:0042221;cellular response to nitrogen compound#GO:1901699 membrane protein complex#GO:0098796;cytoplasmic side of plasma membrane#GO:0009898;plasma membrane protein complex#GO:0098797;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494;extrinsic component of cytoplasmic side of plasma membrane#GO:0031234;side of membrane#GO:0098552;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;cell periphery#GO:0071944;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;cytoplasm#GO:0005737;cytoplasmic side of membrane#GO:0098562;extrinsic component of membrane#GO:0019898;extrinsic component of plasma membrane#GO:0019897 heterotrimeric G-protein#PC00117;G-protein#PC00020 Metabotropic glutamate receptor group I pathway#P00041>G-Protein#P01057;Wnt signaling pathway#P00057>Galpha#P01451;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Gqalpha#P00732;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Galphai/q#P00873;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Galphaq#P00826 HUMAN|HGNC=21587|UniProtKB=Q7Z5A9 Q7Z5A9 TAFA1 PTHR31770:SF2 CHEMOKINE-LIKE PROTEIN TAFA FAMILY MEMBER CHEMOKINE-LIKE PROTEIN TAFA-1 signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545 animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;anatomical structure development#GO:0048856;regulation of cell population proliferation#GO:0042127;system development#GO:0048731;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;developmental process#GO:0032502;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;neurogenesis#GO:0022008;cellular process#GO:0009987;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 chemokine#PC00074;cytokine#PC00083 HUMAN|HGNC=20470|UniProtKB=Q9UK45 Q9UK45 LSM7 PTHR10553:SF44 SMALL NUCLEAR RIBONUCLEOPROTEIN U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM7 binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 U6 snRNP#GO:0005688;Sm-like protein family complex#GO:0120114;catalytic step 2 spliceosome#GO:0071013;U12-type spliceosomal complex#GO:0005689;nuclear protein-containing complex#GO:0140513;small nuclear ribonucleoprotein complex#GO:0030532;nucleus#GO:0005634;protein-containing complex#GO:0032991;ribonucleoprotein complex#GO:1990904;spliceosomal tri-snRNP complex#GO:0097526;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;spliceosomal snRNP complex#GO:0097525;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;spliceosomal complex#GO:0005681;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;U2-type spliceosomal complex#GO:0005684;U2-type prespliceosome#GO:0071004 RNA splicing factor#PC00148 HUMAN|HGNC=5737|UniProtKB=P01594 P01594 IGKV1-33 PTHR23267:SF537 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN KAPPA VARIABLE 1-33-RELATED response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=24716|UniProtKB=Q5U651 Q5U651 RASIP1 PTHR16027:SF4 DILUTE DOMAIN-CONTAINING PROTEIN YPR089W RAS-INTERACTING PROTEIN 1 binding#GO:0005488;enzyme binding#GO:0019899;protein binding#GO:0005515 negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;developmental process#GO:0032502;multicellular organismal process#GO:0032501;negative regulation of response to stimulus#GO:0048585;tube development#GO:0035295;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;anatomical structure development#GO:0048856;system development#GO:0048731;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;tube morphogenesis#GO:0035239;blood vessel development#GO:0001568;multicellular organism development#GO:0007275;anatomical structure formation involved in morphogenesis#GO:0048646;vasculature development#GO:0001944;regulation of small GTPase mediated signal transduction#GO:0051056;negative regulation of signal transduction#GO:0009968;angiogenesis#GO:0001525;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;regulation of intracellular signal transduction#GO:1902531;animal gross anatomical part developmental process#GO:0160108;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;regulation of Rho protein signal transduction#GO:0035023;circulatory system development#GO:0072359;blood vessel morphogenesis#GO:0048514;negative regulation of biological process#GO:0048519;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789 cell-cell junction#GO:0005911;cell junction#GO:0030054;cellular anatomical structure#GO:0110165;anchoring junction#GO:0070161 HUMAN|HGNC=17433|UniProtKB=Q99653 Q99653 CHP1 PTHR46002:SF1 EG:114D9.1 PROTEIN-RELATED CALCINEURIN B HOMOLOGOUS PROTEIN 1 small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;calcium ion binding#GO:0005509;metal ion binding#GO:0046872;cation binding#GO:0043169 negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;regulation of cellular process#GO:0050794;regulation of calcium-mediated signaling#GO:0050848;regulation of cell communication#GO:0010646;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;negative regulation of response to stimulus#GO:0048585;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of signal transduction#GO:0009968;regulation of calcineurin-NFAT signaling cascade#GO:0070884;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=14497|UniProtKB=Q9NV31 Q9NV31 IMP3 PTHR11831:SF1 30S 40S RIBOSOMAL PROTEIN U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP3 rRNA binding#GO:0019843;structural constituent of ribosome#GO:0003735;snoRNA binding#GO:0030515;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723;structural molecule activity#GO:0005198 ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;ribosomal small subunit biogenesis#GO:0042274;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152 membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;protein-containing complex#GO:0032991;small ribosomal subunit#GO:0015935;intracellular organelle#GO:0043229;preribosome#GO:0030684;nucleolus#GO:0005730;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ribosome#GO:0005840;small-subunit processome#GO:0032040;90S preribosome#GO:0030686;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226 ribosomal protein#PC00202;translational protein#PC00263 HUMAN|HGNC=19654|UniProtKB=Q7RTT4 Q7RTT4 SSX8P PTHR14112:SF27 SYNOVIAL SARCOMA, X MEMBER PROTEIN SSX6-RELATED cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 transcription cofactor#PC00217;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=918|UniProtKB=O75752 O75752 B3GALNT1 PTHR11214:SF153 BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE UDP-GALNAC:BETA-1,3-N-ACETYLGALACTOSAMINYLTRANSFERASE 1 hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;catalytic activity#GO:0003824;galactosyltransferase activity#GO:0008378;glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194 primary metabolic process#GO:0044238;cellular process#GO:0009987;carbohydrate biosynthetic process#GO:0016051;carbohydrate metabolic process#GO:0005975;biosynthetic process#GO:0009058;metabolic process#GO:0008152;oligosaccharide biosynthetic process#GO:0009312;oligosaccharide metabolic process#GO:0009311 intracellular organelle#GO:0043229;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 transferase#PC00220;glycosyltransferase#PC00111 HUMAN|HGNC=28565|UniProtKB=Q8N4B4 Q8N4B4 FBXO39 PTHR10706:SF160 F-BOX FAMILY PROTEIN F-BOX ONLY PROTEIN 39 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;enzyme-substrate adaptor activity#GO:0140767;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 catalytic complex#GO:1902494;transferase complex#GO:1990234;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;SCF ubiquitin ligase complex#GO:0019005;intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=29669|UniProtKB=Q96FT9 Q96FT9 IFT43 PTHR33724:SF1 INTRAFLAGELLAR TRANSPORT PROTEIN 43 HOMOLOG INTRAFLAGELLAR TRANSPORT PROTEIN 43 HOMOLOG cilium organization#GO:0044782;localization#GO:0051179;cellular localization#GO:0051641;microtubule-based transport#GO:0099111;intraciliary transport#GO:0042073;cell projection organization#GO:0030030;intraciliary retrograde transport#GO:0035721;microtubule-based movement#GO:0007018;cellular component organization#GO:0016043;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;transport along microtubule#GO:0010970;establishment of localization#GO:0051234;transport#GO:0006810;intracellular transport#GO:0046907;plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton-dependent intracellular transport#GO:0030705;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle organization#GO:0006996 membrane-bounded organelle#GO:0043227;intraciliary transport particle A#GO:0030991;cilium#GO:0005929;intraciliary transport particle#GO:0030990;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 HUMAN|HGNC=17729|UniProtKB=Q8NBZ7 Q8NBZ7 UXS1 PTHR43078:SF54 UDP-GLUCURONIC ACID DECARBOXYLASE-RELATED UDP-GLUCURONIC ACID DECARBOXYLASE 1 carbon-carbon lyase activity#GO:0016830;catalytic activity#GO:0003824;carboxy-lyase activity#GO:0016831;lyase activity#GO:0016829 organophosphate biosynthetic process#GO:0090407;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleobase-containing small molecule metabolic process#GO:0055086;nucleoside phosphate biosynthetic process#GO:1901293;carbohydrate derivative biosynthetic process#GO:1901137;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;nucleotide-sugar metabolic process#GO:0009225 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 lyase#PC00144;decarboxylase#PC00089 HUMAN|HGNC=11644|UniProtKB=Q15906 Q15906 VPS72 PTHR13275:SF4 YL-1 PROTEIN TRANSCRIPTION FACTOR-LIKE 1 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 72 HOMOLOG molecular carrier activity#GO:0140104;protein carrier activity#GO:0140597 cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;chromatin remodeling#GO:0006338;chromatin organization#GO:0006325 protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;membrane-enclosed lumen#GO:0031974;histone deacetylase complex#GO:0000118;nucleus#GO:0005634;chromatin#GO:0000785;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;chromosome#GO:0005694;SWI/SNF superfamily-type complex#GO:0070603;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;INO80-type complex#GO:0097346;intracellular organelle lumen#GO:0070013;ATPase complex#GO:1904949;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;Swr1 complex#GO:0000812 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HUMAN|HGNC=15188|UniProtKB=Q8NH64 Q8NH64 OR51A7 PTHR26450:SF411 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 51A7 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=19300|UniProtKB=Q8N4C7 Q8N4C7 STX19 PTHR19957:SF29 SYNTAXIN SYNTAXIN-19 SNAP receptor activity#GO:0005484;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;membrane fusion#GO:0061025;macromolecule localization#GO:0033036;organelle organization#GO:0006996;membrane organization#GO:0061024;organelle membrane fusion#GO:0090174;organelle fusion#GO:0048284;vesicle-mediated transport#GO:0016192;transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;exocytosis#GO:0006887;intracellular protein localization#GO:0008104;vesicle organization#GO:0016050;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;cellular component organization#GO:0016043;export from cell#GO:0140352;vesicle fusion#GO:0006906;secretion by cell#GO:0032940;protein transport#GO:0015031;localization#GO:0051179;secretion#GO:0046903;cellular localization#GO:0051641 intracellular anatomical structure#GO:0005622;cell periphery#GO:0071944;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;SNARE complex#GO:0031201;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 SNARE protein#PC00034 Nicotinic acetylcholine receptor signaling pathway#P00044>SNARE Complex#P01091;Ionotropic glutamate receptor pathway#P00037>SNARE Complex#P01013;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>SNARE Complex#P01079 HUMAN|HGNC=15582|UniProtKB=Q8WXI7 Q8WXI7 MUC16 PTHR14672:SF1 MUCIN-16 MUCIN-16 HUMAN|HGNC=26219|UniProtKB=Q9BT04 Q9BT04 FUZ PTHR13559:SF1 INTRACELLULAR TRAFFIC PROTEIN-RELATED PROTEIN FUZZY HOMOLOG cell projection organization#GO:0030030;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cell projection assembly#GO:0030031;non-motile cilium assembly#GO:1905515;cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782;plasma membrane bounded cell projection assembly#GO:0120031;organelle assembly#GO:0070925 HUMAN|HGNC=14842|UniProtKB=Q8NGN6 Q8NGN6 OR10G7 PTHR26453:SF7 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 10G7 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 sensory perception#GO:0007600;nervous system process#GO:0050877;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;detection of chemical stimulus#GO:0009593;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;response to chemical#GO:0042221;response to stimulus#GO:0050896;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=15925|UniProtKB=Q9Y3Z3 Q9Y3Z3 SAMHD1 PTHR11373:SF48 DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1 hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787 response to stress#GO:0006950;response to biotic stimulus#GO:0009607;cellular process#GO:0009987;regulation of response to external stimulus#GO:0032101;metabolic process#GO:0008152;purine-containing compound catabolic process#GO:0072523;nucleobase-containing small molecule metabolic process#GO:0055086;phosphorus metabolic process#GO:0006793;defense response to virus#GO:0051607;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;regulation of biological process#GO:0050789;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;nucleotide metabolic process#GO:0009117;nucleobase-containing compound catabolic process#GO:0034655;organophosphate metabolic process#GO:0019637;carbohydrate derivative metabolic process#GO:1901135;response to other organism#GO:0051707;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;regulation of response to stress#GO:0080134;nucleotide catabolic process#GO:0009166;regulation of response to stimulus#GO:0048583;regulation of innate immune response#GO:0045088;defense response#GO:0006952;response to external stimulus#GO:0009605;primary metabolic process#GO:0044238;purine nucleoside triphosphate metabolic process#GO:0009144;regulation of immune system process#GO:0002682;nucleoside phosphate catabolic process#GO:1901292;catabolic process#GO:0009056;nucleoside phosphate metabolic process#GO:0006753;carbohydrate derivative catabolic process#GO:1901136;regulation of response to biotic stimulus#GO:0002831;response to external biotic stimulus#GO:0043207;regulation of defense response#GO:0031347;regulation of immune response#GO:0050776;purine nucleotide catabolic process#GO:0006195;response to virus#GO:0009615;organophosphate catabolic process#GO:0046434 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 hydrolase#PC00121 HUMAN|HGNC=14944|UniProtKB=Q6ZSY5 Q6ZSY5 PPP1R3F PTHR12307:SF40 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 3F protein binding#GO:0005515;carbohydrate binding#GO:0030246;protein phosphatase binding#GO:0019903;polysaccharide binding#GO:0030247;phosphatase binding#GO:0019902;binding#GO:0005488;enzyme binding#GO:0019899 regulation of polysaccharide metabolic process#GO:0032881;biological regulation#GO:0065007;regulation of carbohydrate biosynthetic process#GO:0043255;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of polysaccharide biosynthetic process#GO:0032885;regulation of biosynthetic process#GO:0009889;regulation of glycogen biosynthetic process#GO:0005979;regulation of carbohydrate metabolic process#GO:0006109 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;protein serine/threonine phosphatase complex#GO:0008287;catalytic complex#GO:1902494 phosphatase modulator#PC00184;protein-binding activity modulator#PC00095 HUMAN|HGNC=14784|UniProtKB=Q8WZ94 Q8WZ94 OR5P3 PTHR26452:SF310 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5P3 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 nervous system process#GO:0050877;sensory perception#GO:0007600;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=20568|UniProtKB=Q15629 Q15629 TRAM1 PTHR12371:SF3 TRANSLOCATION ASSOCIATED MEMBRANE PROTEIN TRANSLOCATING CHAIN-ASSOCIATED MEMBRANE PROTEIN 1 intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of protein localization to membrane#GO:0090150;macromolecule localization#GO:0033036;organelle organization#GO:0006996;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;protein insertion into membrane#GO:0051205;localization within membrane#GO:0051668;cellular localization#GO:0051641;localization#GO:0051179;protein insertion into ER membrane#GO:0045048;endoplasmic reticulum organization#GO:0007029;cellular component organization#GO:0016043;protein localization to organelle#GO:0033365 endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;membrane#GO:0016020;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=28494|UniProtKB=Q8TC94 Q8TC94 ACTL9 PTHR11937:SF194 ACTIN ACTIN-LIKE PROTEIN 9 protein binding#GO:0005515;structural constituent of synapse#GO:0098918;kinase binding#GO:0019900;structural constituent of cytoskeleton#GO:0005200;binding#GO:0005488;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;structural molecule activity#GO:0005198 axon development#GO:0061564;neuron projection development#GO:0031175;cellular process#GO:0009987;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;neuron projection morphogenesis#GO:0048812;plasma membrane bounded cell projection morphogenesis#GO:0120039;developmental process#GO:0032502;neuron differentiation#GO:0030182;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;neurogenesis#GO:0022008;cell projection morphogenesis#GO:0048858;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cell motility#GO:0048870;cell morphogenesis#GO:0000902;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell development#GO:0048468;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;anatomical structure development#GO:0048856;axonogenesis#GO:0007409;neuron development#GO:0048666;system development#GO:0048731 H4 histone acetyltransferase complex#GO:1902562;membrane#GO:0016020;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;transferase complex#GO:1990234;cytoskeleton#GO:0005856;plasma membrane bounded cell projection#GO:0120025;chromosome#GO:0005694;intracellular anatomical structure#GO:0005622;axon#GO:0030424;catalytic complex#GO:1902494;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;NuA4 histone acetyltransferase complex#GO:0035267;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;neuron projection#GO:0043005;chromatin#GO:0000785;histone acetyltransferase complex#GO:0000123;cell junction#GO:0030054;actin filament#GO:0005884;cell projection#GO:0042995;organelle#GO:0043226;cellular anatomical structure#GO:0110165;synapse#GO:0045202;actin cytoskeleton#GO:0015629;acetyltransferase complex#GO:1902493;supramolecular fiber#GO:0099512;intracellular organelle#GO:0043229;protein acetyltransferase complex#GO:0031248 actin and actin related protein#PC00039 HUMAN|HGNC=6019|UniProtKB=P08887 P08887 IL6R PTHR23036:SF98 CYTOKINE RECEPTOR INTERLEUKIN-6 RECEPTOR SUBUNIT ALPHA cytokine receptor activity#GO:0004896;immune receptor activity#GO:0140375;cytokine binding#GO:0019955;signaling receptor activity#GO:0038023;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;protein binding#GO:0005515 response to cytokine#GO:0034097;response to chemical#GO:0042221;biological regulation#GO:0065007;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;cell surface receptor signaling pathway#GO:0007166;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;positive regulation of cell population proliferation#GO:0008284;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;cellular response to stimulus#GO:0051716;regulation of cell population proliferation#GO:0042127;cell communication#GO:0007154;response to peptide#GO:1901652;cytokine-mediated signaling pathway#GO:0019221 membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;signaling receptor complex#GO:0043235 transmembrane signal receptor#PC00197 Interleukin signaling pathway#P00036>Receptor subunit alpha#P00992 HUMAN|HGNC=28521|UniProtKB=Q4G163 Q4G163 FBXO43 PTHR15493:SF1 F-BOX ONLY PROTEIN 5 AND 43 F-BOX ONLY PROTEIN 43 enzyme inhibitor activity#GO:0004857;molecular function inhibitor activity#GO:0140678;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234 mitotic cell cycle phase transition#GO:0044772;regulation of cell cycle#GO:0051726;cell cycle phase transition#GO:0044770;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;mitotic cell cycle#GO:0000278;cell cycle process#GO:0022402;regulation of organelle organization#GO:0033043;regulation of meiotic cell cycle#GO:0051445;regulation of biological process#GO:0050789;negative regulation of cellular component organization#GO:0051129;negative regulation of organelle organization#GO:0010639;negative regulation of biological process#GO:0048519;cell cycle#GO:0007049;regulation of mitotic nuclear division#GO:0007088;mitotic cell cycle process#GO:1903047;negative regulation of cell cycle#GO:0045786;negative regulation of cell cycle process#GO:0010948;negative regulation of cellular process#GO:0048523;G1/S transition of mitotic cell cycle#GO:0000082;regulation of nuclear division#GO:0051783;negative regulation of nuclear division#GO:0051784;regulation of cell cycle process#GO:0010564;biological regulation#GO:0065007;regulation of reproductive process#GO:2000241;cellular process#GO:0009987;regulation of mitotic cell cycle#GO:0007346;cell cycle G1/S phase transition#GO:0044843 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=31670|UniProtKB=A6NNW6 A6NNW6 ENO4 PTHR11902:SF30 ENOLASE ENOLASE 4 lyase activity#GO:0016829;carbon-oxygen lyase activity#GO:0016835;hydro-lyase activity#GO:0016836;phosphopyruvate hydratase activity#GO:0004634;catalytic activity#GO:0003824 nucleoside phosphate catabolic process#GO:1901292;catabolic process#GO:0009056;nucleoside phosphate metabolic process#GO:0006753;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate derivative catabolic process#GO:1901136;carbohydrate metabolic process#GO:0005975;primary metabolic process#GO:0044238;nucleoside diphosphate catabolic process#GO:0009134;purine nucleoside triphosphate metabolic process#GO:0009144;purine ribonucleotide catabolic process#GO:0009154;cellular respiration#GO:0045333;organophosphate catabolic process#GO:0046434;ribonucleoside diphosphate catabolic process#GO:0009191;aerobic respiration#GO:0009060;purine ribonucleoside diphosphate catabolic process#GO:0009181;nucleoside diphosphate metabolic process#GO:0009132;purine nucleotide catabolic process#GO:0006195;pyridine-containing compound metabolic process#GO:0072524;nucleobase-containing compound metabolic process#GO:0006139;organophosphate metabolic process#GO:0019637;nucleobase-containing compound catabolic process#GO:0034655;glycolytic process#GO:0006096;purine ribonucleoside triphosphate metabolic process#GO:0009205;carbohydrate derivative metabolic process#GO:1901135;ribonucleotide catabolic process#GO:0009261;energy derivation by oxidation of organic compounds#GO:0015980;ADP metabolic process#GO:0046031;nucleotide catabolic process#GO:0009166;purine ribonucleoside diphosphate metabolic process#GO:0009179;generation of precursor metabolites and energy#GO:0006091;small molecule metabolic process#GO:0044281;pyridine nucleotide catabolic process#GO:0019364;pyruvate metabolic process#GO:0006090;carboxylic acid metabolic process#GO:0019752;phosphorus metabolic process#GO:0006793;monocarboxylic acid metabolic process#GO:0032787;purine-containing compound metabolic process#GO:0072521;ribonucleoside diphosphate metabolic process#GO:0009185;pyridine-containing compound catabolic process#GO:0072526;purine nucleotide metabolic process#GO:0006163;carbohydrate catabolic process#GO:0016052;nucleotide metabolic process#GO:0009117;purine nucleoside diphosphate metabolic process#GO:0009135;ribonucleotide metabolic process#GO:0009259;oxoacid metabolic process#GO:0043436;ribose phosphate metabolic process#GO:0019693;ATP metabolic process#GO:0046034;cellular process#GO:0009987;nicotinamide nucleotide metabolic process#GO:0046496;purine-containing compound catabolic process#GO:0072523;purine nucleoside diphosphate catabolic process#GO:0009137;nucleobase-containing small molecule metabolic process#GO:0055086;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;ADP catabolic process#GO:0046032 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;cytosol#GO:0005829 metabolite interconversion enzyme#PC00262;lyase#PC00144 HUMAN|HGNC=5576|UniProtKB=P01817 P01817 IGHV2-5 PTHR23266:SF330 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 2-5 antigen binding#GO:0003823;binding#GO:0005488 immune system process#GO:0002376;immune effector process#GO:0002252;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;immunoglobulin mediated immune response#GO:0016064;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immune response#GO:0006955;response to stimulus#GO:0050896;adaptive immune response#GO:0002250 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=24944|UniProtKB=Q9NX09 Q9NX09 DDIT4 PTHR12478:SF7 DNA-DAMAGE-INDUCIBLE TRANSCRIPT 4 PROTEIN DDIT4 DNA DAMAGE-INDUCIBLE TRANSCRIPT 4 PROTEIN protein binding#GO:0005515;binding#GO:0005488 negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;response to hypoxia#GO:0001666;response to stress#GO:0006950;cellular process#GO:0009987;regulation of TOR signaling#GO:0032006;negative regulation of response to stimulus#GO:0048585;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;response to decreased oxygen levels#GO:0036293;response to oxygen levels#GO:0070482;response to abiotic stimulus#GO:0009628;programmed cell death#GO:0012501;regulation of biological process#GO:0050789;apoptotic process#GO:0006915;cell death#GO:0008219;response to stimulus#GO:0050896;negative regulation of TOR signaling#GO:0032007;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646 HUMAN|HGNC=25792|UniProtKB=Q9BQ65 Q9BQ65 USB1 PTHR13522:SF3 U6 SNRNA PHOSPHODIESTERASE 1 U6 SNRNA PHOSPHODIESTERASE 1 hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;RNA nuclease activity#GO:0004540;catalytic activity, acting on RNA#GO:0140098;3'-5' exonuclease activity#GO:0008408;3'-5'-RNA exonuclease activity#GO:0000175;exonuclease activity#GO:0004527;nuclease activity#GO:0004518;hydrolase activity#GO:0016787 gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;RNA 3'-end processing#GO:0031123;macromolecule metabolic process#GO:0043170;snRNA processing#GO:0016180;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA biosynthetic process#GO:0032774;snRNA 3'-end processing#GO:0034472;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;snRNA metabolic process#GO:0016073;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=7151|UniProtKB=Q9BYG8 Q9BYG8 GSDMC PTHR16399:SF21 GASDERMIN GASDERMIN-C phospholipid binding#GO:0005543;phosphatidylinositol phosphate binding#GO:1901981;ion binding#GO:0043167;phosphatidylinositol-4,5-bisphosphate binding#GO:0005546;small molecule binding#GO:0036094;anion binding#GO:0043168;binding#GO:0005488;phosphatidylinositol bisphosphate binding#GO:1902936;phosphatidylserine binding#GO:0001786;lipid binding#GO:0008289 defense response to bacterium#GO:0042742;inflammatory response#GO:0006954;response to bacterium#GO:0009617;defense response#GO:0006952;response to external stimulus#GO:0009605;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;response to other organism#GO:0051707;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896 transporter#PC00227 HUMAN|HGNC=14001|UniProtKB=Q9GZV8 Q9GZV8 PRDM14 PTHR16515:SF74 PR DOMAIN ZINC FINGER PROTEIN PR DOMAIN ZINC FINGER PROTEIN 14 transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244;DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=28479|UniProtKB=Q8WTQ4 Q8WTQ4 C16orf78 PTHR35679:SF1 RIKEN CDNA 4933402J07 GENE RIKEN CDNA 4933402J07 GENE HUMAN|HGNC=19894|UniProtKB=Q9Y5R8 Q9Y5R8 TRAPPC1 PTHR23249:SF16 TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 1 molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;guanyl-nucleotide exchange factor activity#GO:0005085 localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;transport#GO:0006810;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;cellular process#GO:0009987 cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;TRAPPII protein complex#GO:1990071;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular protein-containing complex#GO:0140535;vesicle tethering complex#GO:0099023;Golgi apparatus#GO:0005794;cytoplasm#GO:0005737;TRAPP complex#GO:0030008;endomembrane system#GO:0012505;protein-containing complex#GO:0032991 membrane traffic protein#PC00150 HUMAN|HGNC=30010|UniProtKB=Q8N2H9 Q8N2H9 PELI3 PTHR12098:SF9 E3 UBIQUITIN-PROTEIN LIGASE PELLINO-RELATED E3 UBIQUITIN-PROTEIN LIGASE PELLINO HOMOLOG 3 ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740 metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647;macromolecule metabolic process#GO:0043170;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein K63-linked ubiquitination#GO:0070534;primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;cellular process#GO:0009987;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=4025|UniProtKB=O00168 O00168 FXYD1 PTHR14132:SF12 SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT GAMMA PHOSPHOLEMMAN molecular function regulator activity#GO:0098772;channel regulator activity#GO:0016247;transporter regulator activity#GO:0141108;ion channel regulator activity#GO:0099106 regulation of monoatomic ion transmembrane transport#GO:0034765;regulation of biological process#GO:0050789;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of transport#GO:0051050;regulation of transmembrane transport#GO:0034762;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of monoatomic ion transport#GO:0043269;regulation of metal ion transport#GO:0010959;regulation of monoatomic cation transmembrane transport#GO:1904062;regulation of transport#GO:0051049;regulation of localization#GO:0032879 primary active transporter#PC00068;transporter#PC00227 HUMAN|HGNC=14639|UniProtKB=Q96J66 Q96J66 ABCC11 PTHR24223:SF168 ATP-BINDING CASSETTE SUB-FAMILY C ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 11 purine nucleotide transmembrane transporter activity#GO:0015216;nucleobase-containing compound transmembrane transporter activity#GO:0015932;organophosphate ester transmembrane transporter activity#GO:0015605;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 lipid transport#GO:0006869;cellular process#GO:0009987;macromolecule localization#GO:0033036;monocarboxylic acid transport#GO:0015718;organic hydroxy compound transport#GO:0015850;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;organic acid transport#GO:0015849;transport#GO:0006810;carboxylic acid transport#GO:0046942;bile acid and bile salt transport#GO:0015721;lipid localization#GO:0010876 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 ATP-binding cassette (ABC) transporter#PC00003 HUMAN|HGNC=11203|UniProtKB=P57073 P57073 SOX8 PTHR45803:SF2 SOX100B TRANSCRIPTION FACTOR SOX-8 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 nervous system development#GO:0007399;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;multicellular organism development#GO:0007275;animal organ development#GO:0048513;morphogenesis of an epithelium#GO:0002009;neural crest cell differentiation#GO:0014033;negative regulation of RNA biosynthetic process#GO:1902679;mesenchymal cell differentiation#GO:0048762;negative regulation of RNA metabolic process#GO:0051253;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;negative regulation of metabolic process#GO:0009892;cell development#GO:0048468;negative regulation of biological process#GO:0048519;peripheral nervous system development#GO:0007422;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;animal gross anatomical part developmental process#GO:0160108;regulation of nucleobase-containing compound metabolic process#GO:0019219;epithelium development#GO:0060429;multicellular organismal process#GO:0032501;neural crest cell development#GO:0014032;tissue development#GO:0009888;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;stem cell differentiation#GO:0048863;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;mesenchyme development#GO:0060485;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;tissue morphogenesis#GO:0048729;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;system development#GO:0048731;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;stem cell development#GO:0048864 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HMG box transcription factor#PC00024;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=20354|UniProtKB=Q53FD0 Q53FD0 ZC2HC1C PTHR14649:SF1 ZINC FINGER C2HC DOMAIN-CONTAINING PROTEIN 1C ZINC FINGER C2HC DOMAIN-CONTAINING PROTEIN 1C HUMAN|HGNC=102|UniProtKB=Q9NRU3 Q9NRU3 CNNM1 PTHR12064:SF28 METAL TRANSPORTER CNNM METAL TRANSPORTER CNNM1 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 inorganic ion homeostasis#GO:0098771;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;monoatomic ion homeostasis#GO:0050801;homeostatic process#GO:0042592 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=4693|UniProtKB=Q16774 Q16774 GUK1 PTHR23117:SF13 GUANYLATE KINASE-RELATED GUANYLATE KINASE phosphotransferase activity, phosphate group as acceptor#GO:0016776;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleobase-containing compound kinase activity#GO:0019205;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 ribonucleotide metabolic process#GO:0009259;purine nucleoside diphosphate metabolic process#GO:0009135;nucleoside diphosphate metabolic process#GO:0009132;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;nucleotide biosynthetic process#GO:0009165;organophosphate biosynthetic process#GO:0090407;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;purine-containing compound metabolic process#GO:0072521;ribonucleoside diphosphate metabolic process#GO:0009185;purine nucleotide metabolic process#GO:0006163;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;purine ribonucleoside diphosphate metabolic process#GO:0009179;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative biosynthetic process#GO:1901137;nucleoside phosphate biosynthetic process#GO:1901293;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;carbohydrate derivative metabolic process#GO:1901135;ribose phosphate biosynthetic process#GO:0046390;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 transferase#PC00220;kinase#PC00137 De novo purine biosynthesis#P02738>Guanylate kinase#P02904 HUMAN|HGNC=13934|UniProtKB=A0A0B4J1T7 A0A0B4J1T7 LY6G6E PTHR14569:SF0 LYMPHOCYTE ANTIGEN 6 FAMILY MEMBER G6E LYMPHOCYTE ANTIGEN 6 FAMILY MEMBER G6E (PSEUDOGENE) neurotransmitter receptor regulator activity#GO:0099602;molecular function activator activity#GO:0140677;protein binding#GO:0005515;acetylcholine receptor regulator activity#GO:0030548;signaling receptor binding#GO:0005102;binding#GO:0005488;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;signaling receptor regulator activity#GO:0030545 response to oxygen-containing compound#GO:1901700;regulation of signaling#GO:0023051;cellular response to chemical stimulus#GO:0070887;negative regulation of signaling#GO:0023057;response to nitrogen compound#GO:1901698;negative regulation of cell communication#GO:0010648;cell communication#GO:0007154;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;negative regulation of biological process#GO:0048519;negative regulation of G protein-coupled receptor signaling pathway#GO:0045744;signaling#GO:0023052;regulation of cell communication#GO:0010646;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of response to stimulus#GO:0048583;regulation of G protein-coupled receptor signaling pathway#GO:0008277;negative regulation of cellular process#GO:0048523;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987;synaptic signaling#GO:0099536;regulation of signal transduction#GO:0009966;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;response to chemical#GO:0042221;negative regulation of response to stimulus#GO:0048585;acetylcholine receptor signaling pathway#GO:0095500;cellular response to nitrogen compound#GO:1901699 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HUMAN|HGNC=7138|UniProtKB=P55198 P55198 MLLT6 PTHR13793:SF90 PHD FINGER PROTEINS PROTEIN AF-17 chromatin-protein adaptor activity#GO:0140463;histone reader activity#GO:0140566;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 regulation of nucleobase-containing compound metabolic process#GO:0019219;chromatin organization#GO:0006325;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;chromatin remodeling#GO:0006338;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;zinc finger transcription factor#PC00244 HUMAN|HGNC=17015|UniProtKB=Q13610 Q13610 PWP1 PTHR14091:SF0 PERIODIC TRYPTOPHAN PROTEIN 1 PERIODIC TRYPTOPHAN PROTEIN 1 HOMOLOG DNA binding#GO:0003677;binding#GO:0005488;nucleic acid binding#GO:0003676;chromatin binding#GO:0003682;chromatin DNA binding#GO:0031490 regulation of transcription by RNA polymerase I#GO:0006356;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of transcription by RNA polymerase I#GO:0045943;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=12830|UniProtKB=O43542 O43542 XRCC3 PTHR46487:SF1 DNA REPAIR PROTEIN XRCC3 DNA REPAIR PROTEIN XRCC3 binding#GO:0005488;nucleic acid binding#GO:0003676;DNA binding#GO:0003677;four-way junction DNA binding#GO:0000400 cellular response to stress#GO:0033554;mitotic recombination#GO:0006312;recombinational repair#GO:0000725;telomere organization#GO:0032200;double-strand break repair via homologous recombination#GO:0000724;cellular response to stimulus#GO:0051716;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;response to stimulus#GO:0050896;DNA damage response#GO:0006974;DNA recombination#GO:0006310;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;chromosome organization#GO:0051276;telomere maintenance#GO:0000723;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;response to stress#GO:0006950;nucleobase-containing compound metabolic process#GO:0006139;cellular component assembly#GO:0022607 nucleus#GO:0005634;replication fork#GO:0005657;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513 DNA metabolism protein#PC00009 HUMAN|HGNC=5229|UniProtKB=P31689 P31689 DNAJA1 PTHR43888:SF8 DNAJ-LIKE-2, ISOFORM A-RELATED DNAJ HOMOLOG SUBFAMILY A MEMBER 1 binding#GO:0005488;protein-folding chaperone binding#GO:0051087;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;ATPase activator activity#GO:0001671;protein binding#GO:0005515 protein folding#GO:0006457;response to stimulus#GO:0050896;protein localization to organelle#GO:0033365;protein localization to mitochondrion#GO:0070585;cellular response to stimulus#GO:0051716;response to abiotic stimulus#GO:0009628;primary metabolic process#GO:0044238;protein refolding#GO:0042026;localization#GO:0051179;protein metabolic process#GO:0019538;cellular response to stress#GO:0033554;response to temperature stimulus#GO:0009266;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular response to heat#GO:0034605;macromolecule localization#GO:0033036;response to heat#GO:0009408;response to stress#GO:0006950;intracellular protein localization#GO:0008104;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 chaperone#PC00072 HUMAN|HGNC=18941|UniProtKB=Q3LI70 Q3LI70 KRTAP19-6 PTHR38140:SF5 KERATIN-ASSOCIATED PROTEIN 19-3-RELATED KERATIN-ASSOCIATED PROTEIN 19-4-RELATED structural protein#PC00211 HUMAN|HGNC=11335|UniProtKB=Q16384 Q16384 SSX1 PTHR14112:SF26 SYNOVIAL SARCOMA, X MEMBER PROTEIN SSX1 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HUMAN|HGNC=13082|UniProtKB=O94822 O94822 LTN1 PTHR12389:SF0 ZINC FINGER PROTEIN 294 E3 UBIQUITIN-PROTEIN LIGASE LISTERIN catalytic activity, acting on a protein#GO:0140096;ribosomal large subunit binding#GO:0043023;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740;ribonucleoprotein complex binding#GO:0043021;ribosome binding#GO:0043022;ubiquitin-like protein ligase activity#GO:0061659;protein-containing complex binding#GO:0044877;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;binding#GO:0005488;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630 cytoplasmic translation#GO:0002181;catabolic process#GO:0009056;protein biosynthetic process#GO:0160307;modification-dependent protein catabolic process#GO:0019941;rescue of stalled cytosolic ribosome#GO:0072344;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;organelle disassembly#GO:1903008;cellular component disassembly#GO:0022411;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;translation#GO:0006412;biosynthetic process#GO:0009058;proteasomal protein catabolic process#GO:0010498;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;organelle organization#GO:0006996;ubiquitin-dependent protein catabolic process#GO:0006511;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;translational elongation#GO:0006414;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=17306|UniProtKB=Q9HBM6 Q9HBM6 TAF9B PTHR48068:SF5 TAF9 RNA POLYMERASE II, TATA BOX-BINDING PROTEIN (TBP)-ASSOCIATED FACTOR TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 9B protein complex scaffold activity#GO:0140378;structural molecule activity#GO:0005198 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;transcription initiation at RNA polymerase II promoter#GO:0006367;cellular component biogenesis#GO:0044085;protein-DNA complex assembly#GO:0065004;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;cellular component assembly#GO:0022607;transcription by RNA polymerase II#GO:0006366;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;protein-containing complex organization#GO:0043933;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;protein-DNA complex organization#GO:0071824;protein-containing complex assembly#GO:0065003;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;RNA polymerase II preinitiation complex assembly#GO:0051123;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;DNA-templated transcription initiation#GO:0006352;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070 peptidase complex#GO:1905368;RNA polymerase II transcription regulator complex#GO:0090575;membrane-enclosed lumen#GO:0031974;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;membraneless organelle#GO:0043228;transcription regulator complex#GO:0005667;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;nuclear DNA-directed RNA polymerase complex#GO:0055029;RNA polymerase II, holoenzyme#GO:0016591;SAGA-type complex#GO:0070461;membrane-bounded organelle#GO:0043227;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;transcription factor TFIID complex#GO:0005669;SAGA complex#GO:0000124;chromatin#GO:0000785;nuclear protein-containing complex#GO:0140513;histone acetyltransferase complex#GO:0000123;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle lumen#GO:0043233;acetyltransferase complex#GO:1902493;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle#GO:0043229;protein acetyltransferase complex#GO:0031248 Transcription regulation by bZIP transcription factor#P00055>TBP-associated factors#P01385;General transcription regulation#P00023>TBP-associated factors#P00658 HUMAN|HGNC=22200|UniProtKB=Q7L0X0 Q7L0X0 TRIL PTHR24373:SF307 SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN TLR4 INTERACTOR WITH LEUCINE RICH REPEATS signaling receptor activity#GO:0038023;lipid binding#GO:0008289;molecular transducer activity#GO:0060089;lipopolysaccharide binding#GO:0001530;binding#GO:0005488;carbohydrate derivative binding#GO:0097367 signaling#GO:0023052;response to stimulus#GO:0050896;immune response-regulating signaling pathway#GO:0002764;regulation of biological process#GO:0050789;regulation of cytokine production involved in immune response#GO:0002718;immune system process#GO:0002376;regulation of multicellular organismal process#GO:0051239;regulation of response to external stimulus#GO:0032101;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;signal transduction#GO:0007165;positive regulation of immune system process#GO:0002684;positive regulation of response to external stimulus#GO:0032103;immune response-activating signaling pathway#GO:0002757;cell surface receptor signaling pathway#GO:0007166;immune response-activating cell surface receptor signaling pathway#GO:0002429;regulation of response to biotic stimulus#GO:0002831;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of macromolecule metabolic process#GO:0060255;cellular response to stimulus#GO:0051716;innate immune response-activating signaling pathway#GO:0002758;regulation of immune effector process#GO:0002697;cell communication#GO:0007154;regulation of defense response#GO:0031347;regulation of immune response#GO:0050776;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;toll-like receptor 4 signaling pathway#GO:0034142;positive regulation of response to stimulus#GO:0048584;positive regulation of innate immune response#GO:0045089;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;activation of innate immune response#GO:0002218;regulation of cytokine production#GO:0001817;pattern recognition receptor signaling pathway#GO:0002221;regulation of gene expression#GO:0010468;positive regulation of response to biotic stimulus#GO:0002833;regulation of biosynthetic process#GO:0009889;regulation of innate immune response#GO:0045088;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;positive regulation of defense response#GO:0031349;regulation of response to stress#GO:0080134 membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;signaling receptor complex#GO:0043235;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=20088|UniProtKB=Q7Z601 Q7Z601 GPR142 PTHR46272:SF1 G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN G PROTEIN-COUPLED RECEPTOR 142 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007 HUMAN|HGNC=2991|UniProtKB=O60496 O60496 DOK2 PTHR21258:SF14 DOCKING PROTEIN RELATED DOCKING PROTEIN 2 receptor tyrosine kinase binding#GO:0030971;signaling receptor complex adaptor activity#GO:0030159;molecular adaptor activity#GO:0060090;signaling adaptor activity#GO:0035591;protein binding#GO:0005515;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;transmembrane receptor protein tyrosine kinase adaptor activity#GO:0005068;protein tyrosine kinase binding#GO:1990782;signaling receptor binding#GO:0005102;kinase binding#GO:0019900;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;Ras protein signal transduction#GO:0007265;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;signaling#GO:0023052;intracellular signaling cassette#GO:0141124;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 scaffold/adaptor protein#PC00226 Angiogenesis#P00005>Dok-R#P00180 HUMAN|HGNC=15047|UniProtKB=P0C628 P0C628 OR5AC1 PTHR26452:SF407 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5AC1 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 system process#GO:0003008;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;sensory perception#GO:0007600;nervous system process#GO:0050877;sensory perception of chemical stimulus#GO:0007606 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=14132|UniProtKB=Q9BZ29 Q9BZ29 DOCK9 PTHR23317:SF77 DEDICATOR OF CYTOKINESIS DOCK DEDICATOR OF CYTOKINESIS PROTEIN 9 guanyl-nucleotide exchange factor activity#GO:0005085;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cell communication#GO:0010646;regulation of Rho protein signal transduction#GO:0035023;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of small GTPase mediated signal transduction#GO:0051056;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531 protein-binding activity modulator#PC00095;G-protein modulator#PC00022;guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=30794|UniProtKB=Q86XR8 Q86XR8 CEP57 PTHR19336:SF11 UNCHARACTERIZED DUF1167 CENTROSOMAL PROTEIN OF 57 KDA tubulin binding#GO:0015631;cytoskeletal adaptor activity#GO:0008093;cytoskeletal protein binding#GO:0008092;molecular adaptor activity#GO:0060090;protein binding#GO:0005515;binding#GO:0005488;microtubule binding#GO:0008017;protein-macromolecule adaptor activity#GO:0030674 organelle organization#GO:0006996;attachment of spindle microtubules to kinetochore#GO:0008608;cellular process#GO:0009987;cytoskeleton organization#GO:0007010;chromosome localization#GO:0050000;metaphase chromosome alignment#GO:0051310;chromosome segregation#GO:0007059;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;mitotic cell cycle process#GO:1903047;microtubule-based process#GO:0007017;cell cycle#GO:0007049;cellular component organization#GO:0016043;nuclear chromosome segregation#GO:0098813;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cell cycle process#GO:0022402;mitotic cell cycle#GO:0000278;mitotic spindle organization#GO:0007052;organelle localization#GO:0051640;localization#GO:0051179;microtubule cytoskeleton organization#GO:0000226 intracellular membraneless organelle#GO:0043232;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;microtubule cytoskeleton#GO:0015630;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;centrosome#GO:0005813;microtubule organizing center#GO:0005815;spindle#GO:0005819;cytoskeleton#GO:0005856;organelle#GO:0043226;cellular anatomical structure#GO:0110165;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;spindle microtubule#GO:0005876;intracellular organelle#GO:0043229 HUMAN|HGNC=6010|UniProtKB=P31785 P31785 IL2RG PTHR23036:SF172 CYTOKINE RECEPTOR CYTOKINE RECEPTOR COMMON SUBUNIT GAMMA transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488;molecular transducer activity#GO:0060089;protein binding#GO:0005515;cytokine receptor activity#GO:0004896;coreceptor activity#GO:0015026;signaling receptor activity#GO:0038023;cytokine binding#GO:0019955;immune receptor activity#GO:0140375 interleukin-15-mediated signaling pathway#GO:0035723;interleukin-9-mediated signaling pathway#GO:0038113;response to cytokine#GO:0034097;response to chemical#GO:0042221;lymphocyte activation#GO:0046649;cellular process#GO:0009987;signal transduction#GO:0007165;interleukin-7-mediated signaling pathway#GO:0038111;cell surface receptor signaling pathway#GO:0007166;cell development#GO:0048468;signaling#GO:0023052;cell differentiation#GO:0030154;response to stimulus#GO:0050896;mononuclear cell differentiation#GO:1903131;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;leukocyte differentiation#GO:0002521;response to peptide#GO:1901652;immune system process#GO:0002376;biological regulation#GO:0065007;hemopoiesis#GO:0030097;multicellular organismal process#GO:0032501;cellular developmental process#GO:0048869;developmental process#GO:0032502;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;interleukin-2-mediated signaling pathway#GO:0038110;leukocyte activation#GO:0045321;anatomical structure development#GO:0048856;cell communication#GO:0007154;cell activation#GO:0001775;lymphocyte differentiation#GO:0030098;cytokine-mediated signaling pathway#GO:0019221 signaling receptor complex#GO:0043235;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=25017|UniProtKB=Q9P0T4 Q9P0T4 ZNF581 PTHR24390:SF76 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 581 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218 HUMAN|HGNC=2556|UniProtKB=Q93034 Q93034 CUL5 PTHR11932:SF76 CULLIN CULLIN-5 ubiquitin-like protein ligase binding#GO:0044389;binding#GO:0005488;enzyme binding#GO:0019899;protein complex scaffold activity#GO:0140378;protein binding#GO:0005515;ubiquitin protein ligase binding#GO:0031625;structural molecule activity#GO:0005198 ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein ubiquitination#GO:0016567;proteasomal protein catabolic process#GO:0010498;post-translational protein modification#GO:0043687;cellular process#GO:0009987;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein modification by small protein conjugation or removal#GO:0070647;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;catabolic process#GO:0009056;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;protein modification process#GO:0036211 cullin-RING ubiquitin ligase complex#GO:0031461;SCF ubiquitin ligase complex#GO:0019005;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;Cul5-RING ubiquitin ligase complex#GO:0031466;ubiquitin ligase complex#GO:0000151;transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=3782|UniProtKB=P49354 P49354 FNTA PTHR11129:SF5 PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT PROTEIN FARNESYLTRANSFERASE_GERANYLGERANYLTRANSFERASE TYPE-1 SUBUNIT ALPHA catalytic activity#GO:0003824;transferase activity#GO:0016740;prenyltransferase activity#GO:0004659;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;catalytic activity, acting on a protein#GO:0140096 gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;catalytic complex#GO:1902494;transferase complex#GO:1990234 acyltransferase#PC00042;transferase#PC00220 HUMAN|HGNC=9402|UniProtKB=P05129 P05129 PRKCG PTHR24356:SF162 SERINE/THREONINE-PROTEIN KINASE PROTEIN KINASE C GAMMA TYPE catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 non-receptor serine/threonine protein kinase#PC00167 Alpha adrenergic receptor signaling pathway#P00002>PKC#P00075;Apoptosis signaling pathway#P00006>PKCs#P00318;EGF receptor signaling pathway#P00018>PKC#P00565;Histamine H1 receptor mediated signaling pathway#P04385>PKC#P04487;Angiogenesis#P00005>PKC#P00219;VEGF signaling pathway#P00056>PKC#P01425;Endothelin signaling pathway#P00019>PKC#P00568;5HT2 type receptor mediated signaling pathway#P04374>PKC#P04420;Thyrotropin-releasing hormone receptor signaling pathway#P04394>PKC#P04583;Alzheimer disease-amyloid secretase pathway#P00003>PKC#P00109;FGF signaling pathway#P00021>PKC#P00648;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>PKC#P00745;Wnt signaling pathway#P00057>Protein Kinase C#P01458;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>PKC#P01074;Oxytocin receptor mediated signaling pathway#P04391>PKC#P04533 HUMAN|HGNC=29622|UniProtKB=Q8IVS2 Q8IVS2 MCAT PTHR42681:SF8 MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 fatty acid biosynthetic process#GO:0006633;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;small molecule metabolic process#GO:0044281;carboxylic acid biosynthetic process#GO:0046394;cellular process#GO:0009987;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;monocarboxylic acid metabolic process#GO:0032787;monocarboxylic acid biosynthetic process#GO:0072330;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=1509|UniProtKB=Q14790 Q14790 CASP8 PTHR10454:SF162 CASPASE CASPASE-8 catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;cysteine-type endopeptidase activity#GO:0004197;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096 programmed cell death#GO:0012501;cellular response to stimulus#GO:0051716;cell death#GO:0008219;regulation of cellular process#GO:0050794;cell communication#GO:0007154;anatomical structure development#GO:0048856;positive regulation of cellular process#GO:0048522;biological regulation#GO:0065007;hemopoiesis#GO:0030097;positive regulation of neuron apoptotic process#GO:0043525;developmental process#GO:0032502;apoptotic signaling pathway#GO:0097190;cellular developmental process#GO:0048869;regulation of programmed cell death#GO:0043067;leukocyte differentiation#GO:0002521;regulation of biological process#GO:0050789;apoptotic process#GO:0006915;mononuclear cell differentiation#GO:1903131;cell differentiation#GO:0030154;extrinsic apoptotic signaling pathway#GO:0097191;response to stimulus#GO:0050896;myeloid cell differentiation#GO:0030099;positive regulation of programmed cell death#GO:0043068;signaling#GO:0023052;cell development#GO:0048468;regulation of neuron apoptotic process#GO:0043523;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;cell surface receptor signaling pathway#GO:0007166;regulation of apoptotic process#GO:0042981;positive regulation of apoptotic process#GO:0043065;extrinsic apoptotic signaling pathway via death domain receptors#GO:0008625 plasma membrane#GO:0005886;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane protein complex#GO:0098796;membrane#GO:0016020;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;protease#PC00190 Apoptosis signaling pathway#P00006>Caspase 8#P00299;FAS signaling pathway#P00020>Caspase8#P00594;FAS signaling pathway#P00020>Pro-Caspase8#P00604;Huntington disease#P00029>Pro-caspase 8#P00767;Huntington disease#P00029>Caspase 8#P00808 HUMAN|HGNC=4018|UniProtKB=Q11130 Q11130 FUT7 PTHR11929:SF12 ALPHA- 1,3 -FUCOSYLTRANSFERASE ALPHA-(1,3)-FUCOSYLTRANSFERASE 7 transferase activity#GO:0016740;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;fucosyltransferase activity#GO:0008417;glycosyltransferase activity#GO:0016757;alpha-(1->3)-fucosyltransferase activity#GO:0046920 glycosyltransferase#PC00111 HUMAN|HGNC=24328|UniProtKB=Q9Y221 Q9Y221 NIP7 PTHR23415:SF34 CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7 60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7 HOMOLOG cellular component biogenesis#GO:0044085;ribosomal large subunit biogenesis#GO:0042273;ribosome biogenesis#GO:0042254;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;ribonucleoprotein complex biogenesis#GO:0022613 membraneless organelle#GO:0043228;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;preribosome, large subunit precursor#GO:0030687;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;preribosome#GO:0030684;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233 scaffold/adaptor protein#PC00226 HUMAN|HGNC=28063|UniProtKB=Q5HY98 Q5HY98 ZNF766 PTHR24377:SF971 IP01015P-RELATED ZINC FINGER PROTEIN 766 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=496|UniProtKB=P57078 P57078 RIPK4 PTHR24198:SF65 ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN RECEPTOR-INTERACTING SERINE_THREONINE-PROTEIN KINASE 4 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=12121|UniProtKB=A0A0B4J272 A0A0B4J272 TRAV24 PTHR19433:SF123 T-CELL RECEPTOR ALPHA CHAIN V REGION-RELATED T CELL RECEPTOR ALPHA VARIABLE 24 response to bacterium#GO:0009617;response to biotic stimulus#GO:0009607;response to other organism#GO:0051707;response to external stimulus#GO:0009605;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=15129|UniProtKB=Q8NGN4 Q8NGN4 OR10G9 PTHR26453:SF6 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 10G4-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 detection of chemical stimulus#GO:0009593;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;response to stimulus#GO:0050896;response to chemical#GO:0042221;nervous system process#GO:0050877;sensory perception#GO:0007600;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=25318|UniProtKB=Q6P2I3 Q6P2I3 FAHD2B PTHR42796:SF3 FUMARYLACETOACETATE HYDROLASE DOMAIN-CONTAINING PROTEIN 2A-RELATED OXALOACETATE TAUTOMERASE FAHD2A, MITOCHONDRIAL-RELATED hydrolase#PC00121 HUMAN|HGNC=24893|UniProtKB=Q75WM6 Q75WM6 H1-7 PTHR11467:SF14 HISTONE H1 TESTIS-SPECIFIC H1 HISTONE chromatin DNA binding#GO:0031490;chromatin binding#GO:0003682;binding#GO:0005488;nucleic acid binding#GO:0003676;protein-containing complex binding#GO:0044877;nucleosome binding#GO:0031491;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677 negative regulation of cellular process#GO:0048523;cellular component organization or biogenesis#GO:0071840;chromosome organization#GO:0051276;organelle organization#GO:0006996;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;negative regulation of DNA metabolic process#GO:0051053;regulation of DNA recombination#GO:0000018;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;chromosome condensation#GO:0030261;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;negative regulation of DNA recombination#GO:0045910;regulation of biological process#GO:0050789;regulation of DNA metabolic process#GO:0051052;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=11001|UniProtKB=O00337 O00337 SLC28A1 PTHR10590:SF16 SODIUM/NUCLEOSIDE COTRANSPORTER SODIUM_NUCLEOSIDE COTRANSPORTER 1 solute:monoatomic cation symporter activity#GO:0015294;monoatomic ion transmembrane transporter activity#GO:0015075;nucleoside transmembrane transporter activity#GO:0005337;sodium ion transmembrane transporter activity#GO:0015081;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873;secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;solute:sodium symporter activity#GO:0015370;nucleobase-containing compound transmembrane transporter activity#GO:0015932;monoatomic cation transmembrane transporter activity#GO:0008324;carbohydrate derivative transmembrane transporter activity#GO:1901505;symporter activity#GO:0015293 nucleobase-containing compound transport#GO:0015931;carbohydrate derivative transport#GO:1901264;cellular process#GO:0009987;nitrogen compound transport#GO:0071705;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;transport#GO:0006810 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227 HUMAN|HGNC=23363|UniProtKB=Q96MC6 Q96MC6 SLC71A1 PTHR23504:SF77 MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10 SOLUTE CARRIER FAMILY 71 MEMBER 1 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 male gamete generation#GO:0048232;gamete generation#GO:0007276;multicellular organismal process#GO:0032501;reproductive process#GO:0022414;developmental process involved in reproduction#GO:0003006;system process#GO:0003008;multicellular organismal reproductive process#GO:0048609;sexual reproduction#GO:0019953;spermatogenesis#GO:0007283;developmental process#GO:0032502 membrane-bounded organelle#GO:0043227;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;membrane#GO:0016020 transporter#PC00227;secondary carrier transporter#PC00258 HUMAN|HGNC=11502|UniProtKB=O95473 O95473 SYNGR4 PTHR10838:SF22 SYNAPTOGYRIN SYNAPTOGYRIN-4 cellular process#GO:0009987;synaptic vesicle membrane organization#GO:0048499;cellular component organization#GO:0016043;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;export from cell#GO:0140352;vesicle-mediated transport#GO:0016192;transport#GO:0006810;regulated exocytosis#GO:0045055;secretion by cell#GO:0032940;exocytosis#GO:0006887;secretion#GO:0046903;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;localization#GO:0051179 vesicle#GO:0031982;synaptic vesicle#GO:0008021;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;presynapse#GO:0098793;secretory vesicle#GO:0099503;cytoplasm#GO:0005737;transport vesicle#GO:0030133;endomembrane system#GO:0012505;cell junction#GO:0030054 membrane traffic protein#PC00150;membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=10969|UniProtKB=O76082 O76082 SLC22A5 PTHR24064:SF283 SOLUTE CARRIER FAMILY 22 MEMBER ORGANIC CATION_CARNITINE TRANSPORTER 2 quaternary ammonium group transmembrane transporter activity#GO:0015651;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 transport#GO:0006810;cellular process#GO:0009987;quaternary ammonium group transport#GO:0015697;nitrogen compound transport#GO:0071705;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258 HUMAN|HGNC=15014|UniProtKB=Q8NGY9 Q8NGY9 OR2L8 PTHR26453:SF632 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2L8 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 detection of chemical stimulus#GO:0009593;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;response to chemical#GO:0042221;response to stimulus#GO:0050896;nervous system process#GO:0050877;sensory perception#GO:0007600;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=1802|UniProtKB=Q15517 Q15517 CDSN PTHR23207:SF2 CORNEODESMOSIN CORNEODESMOSIN animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502;cell adhesion#GO:0007155;animal organ development#GO:0048513;anatomical structure development#GO:0048856;cell-cell adhesion#GO:0098609;anatomical structure morphogenesis#GO:0009653;cellular process#GO:0009987;animal organ morphogenesis#GO:0009887;skin development#GO:0043588 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=11325|UniProtKB=Q9UNL2 Q9UNL2 SSR3 PTHR13399:SF2 TRANSLOCON-ASSOCIATED PROTEIN TRAP , GAMMA SUBUNIT TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT GAMMA intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=32429|UniProtKB=Q8N4L4 Q8N4L4 SPEM1 PTHR34834:SF1 SPERMATID MATURATION PROTEIN 1 SPERMATID MATURATION PROTEIN 1 developmental process#GO:0032502;spermatogenesis#GO:0007283;flagellated sperm motility#GO:0030317;anatomical structure formation involved in morphogenesis#GO:0048646;microtubule-based process#GO:0007017;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;cellular process#GO:0009987;cilium movement involved in cell motility#GO:0060294;multicellular organismal process#GO:0032501;male gamete generation#GO:0048232;spermatid development#GO:0007286;sexual reproduction#GO:0019953;cilium or flagellum-dependent cell motility#GO:0001539;cilium movement#GO:0003341;spermatid differentiation#GO:0048515;multicellular organismal reproductive process#GO:0048609;anatomical structure development#GO:0048856;cilium-dependent cell motility#GO:0060285;sperm motility#GO:0097722;germ cell development#GO:0007281;anatomical structure morphogenesis#GO:0009653;developmental process involved in reproduction#GO:0003006;cellular process involved in reproduction in multicellular organism#GO:0022412;cell development#GO:0048468;reproductive process#GO:0022414;cell motility#GO:0048870;gamete generation#GO:0007276;microtubule-based movement#GO:0007018;cell differentiation#GO:0030154 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=55711|UniProtKB=P0DX01 P0DX01 GOLGA6L25 PTHR23143:SF31 TRICHOHYALIN-RELATED GOLGIN SUBFAMILY A MEMBER 6-LIKE PROTEIN 1-RELATED actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=18565|UniProtKB=Q8TDC0 Q8TDC0 MYOZ3 PTHR15941:SF15 MYOZENIN MYOZENIN-3 molecular condensate scaffold activity#GO:0140693;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;animal organ development#GO:0048513;cellular component organization or biogenesis#GO:0071840;anatomical structure formation involved in morphogenesis#GO:0048646;striated muscle cell differentiation#GO:0051146;muscle organ development#GO:0007517;cellular anatomical entity morphogenesis#GO:0032989;striated muscle tissue development#GO:0014706;response to stimulus#GO:0050896;cell differentiation#GO:0030154;cell development#GO:0048468;actomyosin structure organization#GO:0031032;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;muscle system process#GO:0003012;anatomical structure morphogenesis#GO:0009653;striated muscle cell development#GO:0055002;animal gross anatomical part developmental process#GO:0160108;skeletal muscle organ development#GO:0060538;tissue development#GO:0009888;multicellular organismal process#GO:0032501;skeletal muscle tissue development#GO:0007519;cellular developmental process#GO:0048869;system process#GO:0003008;developmental process#GO:0032502;muscle structure development#GO:0061061;actin cytoskeleton organization#GO:0030036;muscle cell development#GO:0055001;cellular response to stimulus#GO:0051716;myofibril assembly#GO:0030239;muscle cell differentiation#GO:0042692;anatomical structure development#GO:0048856;muscle tissue development#GO:0060537;supramolecular fiber organization#GO:0097435;cellular component assembly involved in morphogenesis#GO:0010927;organelle assembly#GO:0070925;actin filament-based process#GO:0030029;sarcomere organization#GO:0045214 intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;myofibril#GO:0030016;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;actin cytoskeleton#GO:0015629;membraneless organelle#GO:0043228;sarcomere#GO:0030017;I band#GO:0031674;cytoskeleton#GO:0005856;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;Z disc#GO:0030018;contractile muscle fiber#GO:0043292 non-motor actin binding protein#PC00165;actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=15309|UniProtKB=Q8N146 Q8N146 OR8H3 PTHR48018:SF153 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 8H3 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 G protein-coupled receptor signaling pathway#GO:0007186;sensory perception#GO:0007600;nervous system process#GO:0050877;cell communication#GO:0007154;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;sensory perception of smell#GO:0007608;signaling#GO:0023052;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;signal transduction#GO:0007165;cellular process#GO:0009987;multicellular organismal process#GO:0032501;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=17785|UniProtKB=A6NGE7 A6NGE7 URAD PTHR43466:SF2 2-OXO-4-HYDROXY-4-CARBOXY-5-UREIDOIMIDAZOLINE DECARBOXYLASE-RELATED 2-OXO-4-HYDROXY-4-CARBOXY-5-UREIDOIMIDAZOLINE DECARBOXYLASE-RELATED lyase activity#GO:0016829;carbon-carbon lyase activity#GO:0016830;carboxy-lyase activity#GO:0016831;catalytic activity#GO:0003824 lyase#PC00144;metabolite interconversion enzyme#PC00262;decarboxylase#PC00089 HUMAN|HGNC=33584|UniProtKB=A1A5D9 A1A5D9 BICDL2 PTHR32123:SF11 BICD FAMILY-LIKE CARGO ADAPTER BICD FAMILY-LIKE CARGO ADAPTER 2 microtubule-based movement#GO:0007018;establishment of organelle localization#GO:0051656;localization#GO:0051179;cellular localization#GO:0051641;microtubule-based transport#GO:0099111;organelle localization#GO:0051640;establishment of vesicle localization#GO:0051650;organelle transport along microtubule#GO:0072384;cytoskeleton-dependent intracellular transport#GO:0030705;vesicle localization#GO:0051648;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;vesicle cytoskeletal trafficking#GO:0099518;microtubule-based process#GO:0007017;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;transport#GO:0006810;vesicle transport along microtubule#GO:0047496;intracellular transport#GO:0046907 membrane trafficking regulatory protein#PC00151;membrane traffic protein#PC00150 HUMAN|HGNC=6297|UniProtKB=O43525 O43525 KCNQ3 PTHR47735:SF11 POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4 POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 3 transporter activity#GO:0005215;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261;potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267 transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;transport#GO:0006810;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;cellular process#GO:0009987 plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;membrane#GO:0016020;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;cation channel complex#GO:0034703;voltage-gated potassium channel complex#GO:0008076 voltage-gated ion channel#PC00241;transporter#PC00227 HUMAN|HGNC=668|UniProtKB=P62745 P62745 RHOB PTHR24072:SF0 RHO FAMILY GTPASE RHO-RELATED GTP-BINDING PROTEIN RHOB GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;guanyl nucleotide binding#GO:0019001;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;nucleoside phosphate binding#GO:1901265;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;ribonucleotide binding#GO:0032553;hydrolase activity, acting on acid anhydrides#GO:0016817;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;carbohydrate derivative binding#GO:0097367;hydrolase activity#GO:0016787;small molecule binding#GO:0036094;anion binding#GO:0043168;ion binding#GO:0043167;GTPase activity#GO:0003924;ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleotide binding#GO:0000166;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462 actin filament organization#GO:0007015;cellular component organization or biogenesis#GO:0071840;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;cellular process#GO:0009987;signal transduction#GO:0007165;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;cell communication#GO:0007154;actin filament-based process#GO:0030029;signaling#GO:0023052;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cellular component organization#GO:0016043 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein#PC00020;small GTPase#PC00208 Axon guidance mediated by Slit/Robo#P00008>Rho#P00355;Integrin signalling pathway#P00034>Rho#P00948;Ras Pathway#P04393>Rho#P04578;PDGF signaling pathway#P00047>Ras#P01154;Cytoskeletal regulation by Rho GTPase#P00016>Rho#P00507;Angiogenesis#P00005>GTPase#P00254 HUMAN|HGNC=7579|UniProtKB=P35579 P35579 MYH9 PTHR45615:SF16 MYOSIN HEAVY CHAIN, NON-MUSCLE MYOSIN-9 polypeptide conformation or assembly isomerase activity#GO:0120544;binding#GO:0005488;actin filament binding#GO:0051015;actin binding#GO:0003779;ATP-dependent activity#GO:0140657;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;microfilament motor activity#GO:0000146;catalytic activity#GO:0003824;cytoskeletal protein binding#GO:0008092;macromolecular conformation isomerase activity#GO:0120543;cytoskeletal motor activity#GO:0003774;isomerase activity#GO:0016853 myosin complex#GO:0016459;actin cytoskeleton#GO:0015629;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;organelle#GO:0043226;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 actin or actin-binding cytoskeletal protein#PC00041 Cytoskeletal regulation by Rho GTPase#P00016>Myosin#P00522;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Myosin#P00867;Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HUMAN|HGNC=1340|UniProtKB=Q86T20 Q86T20 SMIM29 PTHR47730:SF1 SMALL INTEGRAL MEMBRANE PROTEIN 29 SMALL INTEGRAL MEMBRANE PROTEIN 29 HUMAN|HGNC=3213|UniProtKB=P26641 P26641 EEF1G PTHR43986:SF4 ELONGATION FACTOR 1-GAMMA ELONGATION FACTOR 1-GAMMA macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;translational elongation#GO:0006414;metabolic process#GO:0008152;translation#GO:0006412;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=10978|UniProtKB=Q8NFF2 Q8NFF2 SLC24A4 PTHR10846:SF21 SODIUM/POTASSIUM/CALCIUM EXCHANGER SODIUM_POTASSIUM_CALCIUM EXCHANGER 4 potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;calcium channel activity#GO:0005262;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;antiporter activity#GO:0015297;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873 cellular homeostasis#GO:0019725;calcium ion transport#GO:0006816;intracellular calcium ion homeostasis#GO:0006874;system process#GO:0003008;intracellular chemical homeostasis#GO:0055082;establishment of localization#GO:0051234;intracellular monoatomic cation homeostasis#GO:0030003;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;transport#GO:0006810;sensory perception of chemical stimulus#GO:0007606;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;multicellular organismal process#GO:0032501;cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;nervous system process#GO:0050877;inorganic ion homeostasis#GO:0098771;sensory perception#GO:0007600;calcium ion homeostasis#GO:0055074;metal ion transport#GO:0030001;homeostatic process#GO:0042592;sensory perception of smell#GO:0007608;calcium ion transmembrane transport#GO:0070588;intracellular monoatomic ion homeostasis#GO:0006873 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 secondary carrier transporter#PC00258 HUMAN|HGNC=4852|UniProtKB=Q13547 Q13547 HDAC1 PTHR10625:SF49 HISTONE DEACETYLASE HDAC1-RELATED HISTONE DEACETYLASE 1 deacetylase activity#GO:0019213;catalytic activity, acting on a protein#GO:0140096;histone modifying activity#GO:0140993;catalytic activity#GO:0003824;histone deacetylase activity#GO:0004407;deacylase activity#GO:0160215 chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;heterochromatin formation#GO:0031507;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;heterochromatin organization#GO:0070828;negative regulation of biosynthetic process#GO:0009890;chromatin organization#GO:0006325;biological regulation#GO:0065007;cellular component assembly#GO:0022607;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;epigenetic regulation of gene expression#GO:0040029;regulation of macromolecule biosynthetic process#GO:0010556;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of gene expression, epigenetic#GO:0045814;cellular component organization or biogenesis#GO:0071840;negative regulation of cellular process#GO:0048523 histone deacetylase complex#GO:0000118;membrane-enclosed lumen#GO:0031974;chromatin#GO:0000785;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;transcription regulator complex#GO:0005667;organelle lumen#GO:0043233;chromosome#GO:0005694;SWI/SNF superfamily-type complex#GO:0070603;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ATPase complex#GO:1904949;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 Wnt signaling pathway#P00057>Histone deacetylase#P01472;p53 pathway#P00059>HDAC1#P04612 HUMAN|HGNC=4429|UniProtKB=Q14789 Q14789 GOLGB1 PTHR18887:SF2 GOLGI-ASSOCIATED PROTEIN GCP360-RELATED GOLGIN SUBFAMILY B MEMBER 1 cis-Golgi network#GO:0005801;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793 HUMAN|HGNC=26006|UniProtKB=Q6DKK2 Q6DKK2 TTC19 PTHR13143:SF6 TETRATRICOPEPTIDE REPEAT PROTEIN 19 TETRATRICOPEPTIDE REPEAT PROTEIN 19, MITOCHONDRIAL cytochrome complex assembly#GO:0017004;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;cellular component assembly#GO:0022607;mitochondrial respiratory chain complex assembly#GO:0033108;mitochondrion organization#GO:0007005;mitochondrial respiratory chain complex III assembly#GO:0034551 organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966 HUMAN|HGNC=16521|UniProtKB=Q14964 Q14964 RAB39A PTHR47979:SF3 DRAB11-RELATED RAS-RELATED PROTEIN RAB-39A ribonucleotide binding#GO:0032553;hydrolase activity, acting on acid anhydrides#GO:0016817;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;carbohydrate derivative binding#GO:0097367;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;guanyl nucleotide binding#GO:0019001;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;nucleoside phosphate binding#GO:1901265;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleotide binding#GO:0000166;anion binding#GO:0043168;small molecule binding#GO:0036094;GTPase activity#GO:0003924;ion binding#GO:0043167;hydrolase activity#GO:0016787 endocytosis#GO:0006897;vesicle fusion#GO:0006906;cellular component organization#GO:0016043;localization#GO:0051179;vacuole organization#GO:0007033;organelle assembly#GO:0070925;vesicle-mediated transport#GO:0016192;cellular component assembly#GO:0022607;organelle fusion#GO:0048284;organelle membrane fusion#GO:0090174;membrane organization#GO:0061024;membrane fusion#GO:0061025;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;lysosome organization#GO:0007040;cellular process#GO:0009987;import into cell#GO:0098657;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;vesicle organization#GO:0016050;phagocytosis#GO:0006909;phagolysosome assembly#GO:0001845;transport#GO:0006810;lytic vacuole organization#GO:0080171 G-protein#PC00020;small GTPase#PC00208 HUMAN|HGNC=8684|UniProtKB=Q9Y5F0 Q9Y5F0 PCDHB13 PTHR24028:SF363 CADHERIN-87A PROTOCADHERIN BETA-13 cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 cell adhesion molecule#PC00069;cadherin#PC00057 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HUMAN|HGNC=30024|UniProtKB=Q8IYB4 Q8IYB4 PEX5L PTHR10130:SF1 PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR PEX5 PEX5-RELATED PROTEIN molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;signal sequence receptor activity#GO:0005048 transmembrane transport#GO:0055085;cellular localization#GO:0051641;localization#GO:0051179;protein transport#GO:0015031;peroxisomal transport#GO:0043574;peroxisome organization#GO:0007031;protein localization to organelle#GO:0033365;protein import into peroxisome matrix#GO:0016558;cellular component organization#GO:0016043;establishment of localization#GO:0051234;intracellular protein transmembrane transport#GO:0065002;cellular component organization or biogenesis#GO:0071840;establishment of protein localization to organelle#GO:0072594;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;protein transmembrane transport#GO:0071806;transport#GO:0006810;protein transmembrane import into intracellular organelle#GO:0044743;organelle organization#GO:0006996;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;cytosol#GO:0005829;peroxisome#GO:0005777;membrane#GO:0016020;microbody#GO:0042579;organelle#GO:0043226;peroxisomal membrane#GO:0005778;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 membrane traffic protein#PC00150;membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=29243|UniProtKB=Q9P2N5 Q9P2N5 RBM27 PTHR14398:SF1 RNA RECOGNITION RRM/RNP DOMAIN RNA-BINDING PROTEIN 27 nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HUMAN|HGNC=18714|UniProtKB=Q9NPI6 Q9NPI6 DCP1A PTHR16290:SF4 TRANSCRIPTION FACTOR SMIF DECAPPING ENZYME DCP1 MRNA-DECAPPING ENZYME 1A nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;RNA binding#GO:0003723 regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;macromolecule metabolic process#GO:0043170;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;nucleobase-containing compound catabolic process#GO:0034655;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid catabolic process#GO:0141188;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;RNA metabolic process#GO:0016070;RNA decapping#GO:0110154;RNA catabolic process#GO:0006401;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789 cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;supramolecular complex#GO:0099080;organelle#GO:0043226;ribonucleoprotein granule#GO:0035770;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;P-body#GO:0000932;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 RNA processing factor#PC00147;mRNA capping factor#PC00145 TGF-beta signaling pathway#P00052>Co-activators corepressors#P01282 HUMAN|HGNC=14052|UniProtKB=P49406 P49406 MRPL19 PTHR15680:SF21 RIBOSOMAL PROTEIN L19 LARGE RIBOSOMAL SUBUNIT PROTEIN BL19M structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;mitochondrial large ribosomal subunit#GO:0005762;membraneless organelle#GO:0043228;ribosome#GO:0005840;mitochondrion#GO:0005739;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;organellar ribosome#GO:0000313;mitochondrial ribosome#GO:0005761;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 translational protein#PC00263;ribosomal protein#PC00202 HUMAN|HGNC=2027|UniProtKB=P51801 P51801 CLCNKB PTHR45720:SF3 CHLORIDE CHANNEL PROTEIN 2 CHLORIDE CHANNEL PROTEIN CLC-KB voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;voltage-gated channel activity#GO:0022832;monoatomic anion channel activity#GO:0005253;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;chloride transmembrane transporter activity#GO:0015108;chloride channel activity#GO:0005254;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic anion transmembrane transporter activity#GO:0008509;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;voltage-gated monoatomic anion channel activity#GO:0008308 establishment of localization#GO:0051234;localization#GO:0051179;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698;monoatomic anion transport#GO:0006820;chloride transport#GO:0006821;transport#GO:0006810 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=29201|UniProtKB=Q9ULR0 Q9ULR0 ISY1 PTHR13021:SF8 PRE-MRNA-SPLICING FACTOR ISY1 PRE-MRNA-SPLICING FACTOR ISY1 HOMOLOG nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;mRNA splice site recognition#GO:0006376;cellular component assembly#GO:0022607;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;cellular component biogenesis#GO:0044085;protein-containing complex organization#GO:0043933;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;protein-RNA complex organization#GO:0071826;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;protein-containing complex assembly#GO:0065003;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;protein-RNA complex assembly#GO:0022618;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;spliceosomal complex assembly#GO:0000245;RNA splicing, via transesterification reactions#GO:0000375 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;Prp19 complex#GO:0000974;membrane-bounded organelle#GO:0043227;catalytic step 2 spliceosome#GO:0071013;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;post-mRNA release spliceosomal complex#GO:0071014;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226 RNA splicing factor#PC00148;RNA processing factor#PC00147 HUMAN|HGNC=26336|UniProtKB=Q6PEW0 Q6PEW0 PRSS54 PTHR24256:SF577 TRYPTASE-RELATED INACTIVE SERINE PROTEASE 54 peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;catalytic activity#GO:0003824;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;serine-type peptidase activity#GO:0008236 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;proteolysis#GO:0006508;primary metabolic process#GO:0044238;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 serine protease#PC00203 HUMAN|HGNC=29813|UniProtKB=Q9H0E3 Q9H0E3 SAP130 PTHR13497:SF3 HISTONE DEACETYLASE COMPLEX SUBUNIT SAP130 HISTONE DEACETYLASE COMPLEX SUBUNIT SAP130 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519 nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;protein-containing complex#GO:0032991;nucleus#GO:0005634;chromatin#GO:0000785;histone deacetylase complex#GO:0000118;membrane-enclosed lumen#GO:0031974;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Sin3-type complex#GO:0070822;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;chromosome#GO:0005694;organelle lumen#GO:0043233 histone modifying enzyme#PC00261 HUMAN|HGNC=26197|UniProtKB=Q8N6T0 Q8N6T0 TOP6BL PTHR14652:SF2 TYPE 2 DNA TOPOISOMERASE 6 SUBUNIT B-LIKE TYPE 2 DNA TOPOISOMERASE 6 SUBUNIT B-LIKE cell cycle#GO:0007049;meiotic cell cycle process#GO:1903046;cellular component organization#GO:0016043;meiosis I#GO:0007127;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;reciprocal homologous recombination#GO:0140527;cell cycle process#GO:0022402;homologous recombination#GO:0035825;reproductive process#GO:0022414;meiosis I cell cycle process#GO:0061982;nuclear division#GO:0000280;sexual reproduction#GO:0019953;reciprocal meiotic recombination#GO:0007131;organelle fission#GO:0048285;organelle organization#GO:0006996;meiotic DNA double-strand break formation#GO:0042138;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;meiotic cell cycle#GO:0051321;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;DNA recombination#GO:0006310;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;meiotic nuclear division#GO:0140013 DNA metabolism protein#PC00009 HUMAN|HGNC=7458|UniProtKB=P03897 P03897 MT-ND3 PTHR11058:SF26 NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3 NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3 primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804;oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor#GO:0016655;oxidoreductase activity#GO:0016491;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;proton transmembrane transporter activity#GO:0015078;catalytic activity#GO:0003824;monoatomic cation transmembrane transporter activity#GO:0008324;oxidoreductase activity, acting on NAD(P)H#GO:0016651;electron transfer activity#GO:0009055;NADH dehydrogenase activity#GO:0003954 transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;respiratory chain complex I#GO:0045271;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;membrane#GO:0016020;oxidoreductase complex#GO:1990204;membrane protein complex#GO:0098796;respiratory chain complex#GO:0098803 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HUMAN|HGNC=3604|UniProtKB=P35556 P35556 FBN2 PTHR24039:SF26 FIBRILLIN-RELATED FIBRILLIN-2 signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;hormone activity#GO:0005179 chemical homeostasis#GO:0048878;metabolic process#GO:0008152;monosaccharide metabolic process#GO:0005996;glucose homeostasis#GO:0042593;glucose metabolic process#GO:0006006;cellular process#GO:0009987;carbohydrate homeostasis#GO:0033500;hexose metabolic process#GO:0019318;primary metabolic process#GO:0044238;carbohydrate metabolic process#GO:0005975;homeostatic process#GO:0042592;small molecule metabolic process#GO:0044281 extracellular matrix structural protein#PC00103 HUMAN|HGNC=7640|UniProtKB=Q99733 Q99733 NAP1L4 PTHR11875:SF75 TESTIS-SPECIFIC Y-ENCODED PROTEIN NUCLEOSOME ASSEMBLY PROTEIN 1-LIKE 4 protein binding#GO:0005515;binding#GO:0005488;chromatin binding#GO:0003682;histone binding#GO:0042393 protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;nucleosome organization#GO:0034728;protein-DNA complex organization#GO:0071824;chromatin remodeling#GO:0006338;chromatin organization#GO:0006325;protein-DNA complex assembly#GO:0065004;cellular component assembly#GO:0022607;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=1940|UniProtKB=P24386 P24386 CHM PTHR11787:SF12 RAB GDP-DISSOCIATION INHIBITOR RAB PROTEINS GERANYLGERANYLTRANSFERASE COMPONENT A 1 establishment of protein localization#GO:0045184;cellular process#GO:0009987;establishment of protein localization to membrane#GO:0090150;vesicle-mediated transport#GO:0016192;protein targeting#GO:0006605;localization within membrane#GO:0051668;transport#GO:0006810;protein targeting to membrane#GO:0006612;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex#GO:1990234;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cytosol#GO:0005829;nucleus#GO:0005634 protein-binding activity modulator#PC00095;G-protein modulator#PC00022 HUMAN|HGNC=2054|UniProtKB=Q9NY25 Q9NY25 CLEC5A PTHR47536:SF1 C-TYPE LECTIN DOMAIN FAMILY 5 MEMBER A C-TYPE LECTIN DOMAIN FAMILY 5 MEMBER A virus receptor activity#GO:0001618;protein binding#GO:0005515;binding#GO:0005488 response to biotic stimulus#GO:0009607;response to stress#GO:0006950;immune response#GO:0006955;defense response to symbiont#GO:0140546;response to stimulus#GO:0050896;defense response to other organism#GO:0098542;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to other organism#GO:0051707;immune system process#GO:0002376;innate immune response#GO:0045087;response to external stimulus#GO:0009605;defense response#GO:0006952 HUMAN|HGNC=8997|UniProtKB=P48426 P48426 PIP4K2A PTHR23086:SF21 PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE TYPE-2 ALPHA phosphotransferase activity, alcohol group as acceptor#GO:0016773;lipid kinase activity#GO:0001727;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphatidylinositol kinase activity#GO:0052742;catalytic activity#GO:0003824;transferase activity#GO:0016740 phosphatidylinositol phosphate biosynthetic process#GO:0046854;organophosphate biosynthetic process#GO:0090407;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phospholipid biosynthetic process#GO:0008654;glycerolipid metabolic process#GO:0046486;phospholipid metabolic process#GO:0006644;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;lipid biosynthetic process#GO:0008610;glycerophospholipid metabolic process#GO:0006650;biosynthetic process#GO:0009058 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 kinase#PC00137;transferase#PC00220 HUMAN|HGNC=16937|UniProtKB=O75915 O75915 ARL6IP5 PTHR12859:SF2 PRA1 PROTEIN PRA1 FAMILY PROTEIN 3 regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of localization#GO:0032879;biological regulation#GO:0065007;regulation of transport#GO:0051049;negative regulation of transport#GO:0051051 cellular anatomical structure#GO:0110165;membrane#GO:0016020 amino acid transporter#PC00046;transporter#PC00227 HUMAN|HGNC=11758|UniProtKB=Q92734 Q92734 TFG PTHR15335:SF7 PROTEIN TFG PROTEIN TFG endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;transport#GO:0006810;Golgi vesicle transport#GO:0048193;intracellular transport#GO:0046907;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;endoplasmic reticulum exit site#GO:0070971;intracellular organelle#GO:0043229 membrane traffic protein#PC00150 HUMAN|HGNC=6677|UniProtKB=P06858 P06858 LPL PTHR11610:SF3 LIPASE LIPOPROTEIN LIPASE hydrolase activity, acting on ester bonds#GO:0016788;lipase activity#GO:0016298;catalytic activity#GO:0003824;binding#GO:0005488;protein binding#GO:0005515;hydrolase activity#GO:0016787 metabolic process#GO:0008152;lipid metabolic process#GO:0006629;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;lipid catabolic process#GO:0016042;cellular process#GO:0009987;catabolic process#GO:0009056;multicellular organismal process#GO:0032501;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 lipase#PC00143;metabolite interconversion enzyme#PC00262;hydrolase#PC00121 2-arachidonoylglycerol biosynthesis#P05726>DGL#P05736 HUMAN|HGNC=7551|UniProtKB=Q14896 Q14896 MYBPC3 PTHR13817:SF20 TITIN MYOSIN-BINDING PROTEIN C, CARDIAC-TYPE structural molecule activity#GO:0005198 cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;heart development#GO:0007507;striated muscle tissue development#GO:0014706;cellular anatomical entity morphogenesis#GO:0032989;muscle organ development#GO:0007517;striated muscle cell differentiation#GO:0051146;anatomical structure formation involved in morphogenesis#GO:0048646;animal organ development#GO:0048513;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;anatomical structure morphogenesis#GO:0009653;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;cell development#GO:0048468;actomyosin structure organization#GO:0031032;circulatory system development#GO:0072359;cell differentiation#GO:0030154;animal gross anatomical part developmental process#GO:0160108;striated muscle cell development#GO:0055002;multicellular organismal process#GO:0032501;tissue development#GO:0009888;developmental process#GO:0032502;cardiac muscle tissue development#GO:0048738;cellular developmental process#GO:0048869;heart morphogenesis#GO:0003007;myofibril assembly#GO:0030239;muscle cell differentiation#GO:0042692;muscle cell development#GO:0055001;actin cytoskeleton organization#GO:0030036;muscle structure development#GO:0061061;animal organ morphogenesis#GO:0009887;sarcomere organization#GO:0045214;actin filament-based process#GO:0030029;cellular component assembly involved in morphogenesis#GO:0010927;organelle assembly#GO:0070925;system development#GO:0048731;supramolecular fiber organization#GO:0097435;muscle tissue development#GO:0060537;anatomical structure development#GO:0048856;tissue morphogenesis#GO:0048729 M band#GO:0031430;intracellular organelle#GO:0043229;sarcomere#GO:0030017;membraneless organelle#GO:0043228;myofibril#GO:0030016;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;A band#GO:0031672;contractile muscle fiber#GO:0043292;organelle#GO:0043226;supramolecular complex#GO:0099080;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737 structural protein#PC00211 HUMAN|HGNC=13887|UniProtKB=Q9H221 Q9H221 ABCG8 PTHR48041:SF71 ABC TRANSPORTER G FAMILY MEMBER 28 ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 8 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;sterol transfer activity#GO:0120015;active transmembrane transporter activity#GO:0022804;cholesterol transfer activity#GO:0120020;primary active transmembrane transporter activity#GO:0015399;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626;lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104;lipid transfer activity#GO:0120013 cholesterol efflux#GO:0033344;cellular process#GO:0009987;macromolecule localization#GO:0033036;cholesterol transport#GO:0030301;lipid transport#GO:0006869;chemical homeostasis#GO:0048878;transport#GO:0006810;cholesterol homeostasis#GO:0042632;establishment of localization#GO:0051234;sterol transport#GO:0015918;lipid homeostasis#GO:0055088;homeostatic process#GO:0042592;lipid localization#GO:0010876;organic hydroxy compound transport#GO:0015850;localization#GO:0051179;transmembrane transport#GO:0055085 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;signaling receptor complex#GO:0043235;cell periphery#GO:0071944 transporter#PC00227;primary active transporter#PC00068;ATP-binding cassette (ABC) transporter#PC00003 HUMAN|HGNC=23794|UniProtKB=Q86VP3 Q86VP3 PACS2 PTHR13280:SF15 PHOSPHOFURIN ACIDIC CLUSTER SORTING PROTEIN PHOSPHOFURIN ACIDIC CLUSTER SORTING PROTEIN 2 protein localization to cell periphery#GO:1990778;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;intracellular protein localization#GO:0008104;autophagosome assembly#GO:0000045;macromolecule localization#GO:0033036;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;autophagy#GO:0006914;cellular process#GO:0009987;autophagosome organization#GO:1905037;cellular component assembly#GO:0022607;macroautophagy#GO:0016236;organelle assembly#GO:0070925;localization within membrane#GO:0051668;localization#GO:0051179;cellular localization#GO:0051641;vacuole organization#GO:0007033;process utilizing autophagic mechanism#GO:0061919;protein localization to membrane#GO:0072657;cellular component organization#GO:0016043;protein localization to plasma membrane#GO:0072659;catabolic process#GO:0009056 HUMAN|HGNC=30834|UniProtKB=Q8IWR1 Q8IWR1 TRIM59 PTHR24098:SF14 OUTER SEGMENT 5 TRIPARTITE MOTIF-CONTAINING PROTEIN 59 plasma membrane bounded cell projection organization#GO:0120036;cell projection organization#GO:0030030;cellular component assembly#GO:0022607;cellular process#GO:0009987;cell projection assembly#GO:0030031;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cilium organization#GO:0044782;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection assembly#GO:0120031;organelle assembly#GO:0070925 membrane-bounded organelle#GO:0043227;intraciliary transport particle B#GO:0030992;cilium#GO:0005929;intraciliary transport particle#GO:0030990;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226 HUMAN|HGNC=13644|UniProtKB=Q9P2F9 Q9P2F9 ZNF319 PTHR24376:SF95 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 319 gene-specific transcriptional regulator#PC00264;zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=3347|UniProtKB=Q9Y2C4 Q9Y2C4 EXOG PTHR13966:SF23 ENDONUCLEASE RELATED NUCLEASE EXOG, MITOCHONDRIAL catalytic activity, acting on DNA#GO:0140097;endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;RNA endonuclease activity#GO:0004521;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;DNA nuclease activity#GO:0004536;hydrolase activity#GO:0016787;DNA endonuclease activity#GO:0004520;nuclease activity#GO:0004518;5'-3' exonuclease activity#GO:0008409;exonuclease activity#GO:0004527 DNA catabolic process#GO:0006308;cellular component disassembly#GO:0022411;cell death#GO:0008219;apoptotic process#GO:0006915;execution phase of apoptosis#GO:0097194;programmed cell death#GO:0012501;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;catabolic process#GO:0009056;DNA metabolic process#GO:0006259;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;nucleic acid catabolic process#GO:0141188;cellular process#GO:0009987;nucleobase-containing compound catabolic process#GO:0034655;nucleobase-containing compound metabolic process#GO:0006139;apoptotic DNA fragmentation#GO:0006309 organelle membrane#GO:0031090;cytoplasm#GO:0005737;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;nucleus#GO:0005634;mitochondrial membrane#GO:0031966;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;mitochondrion#GO:0005739 HUMAN|HGNC=23678|UniProtKB=B1ANY3 B1ANY3 FAM220BP PTHR31980:SF2 PROTEIN FAM220A PROTEIN FAM220BP-RELATED membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=16064|UniProtKB=Q9UJY4 Q9UJY4 GGA2 PTHR45905:SF2 GOLGI-LOCALIZED, GAMMA-ADAPTIN EAR CONTAINING, ARF BINDING PROTEIN ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA2 protein binding#GO:0005515;small GTPase binding#GO:0031267;enzyme binding#GO:0019899;binding#GO:0005488 establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;post-Golgi vesicle-mediated transport#GO:0006892;intracellular protein localization#GO:0008104;vesicle-mediated transport to the plasma membrane#GO:0098876;transport#GO:0006810;Golgi vesicle transport#GO:0048193;localization within membrane#GO:0051668;vesicle-mediated transport#GO:0016192;Golgi to plasma membrane transport#GO:0006893;macromolecule localization#GO:0033036;cellular process#GO:0009987 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;Golgi apparatus subcompartment#GO:0098791;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226 Heme biosynthesis#P02746>Glutamyl-tRNA-synthetase#P02977 HUMAN|HGNC=30299|UniProtKB=Q5T3J3 Q5T3J3 LRIF1 PTHR16131:SF2 LIGAND-DEPENDENT NUCLEAR RECEPTOR-INTERACTING FACTOR 1 LIGAND-DEPENDENT NUCLEAR RECEPTOR-INTERACTING FACTOR 1 HUMAN|HGNC=5740|UniProtKB=P01597 P01597 IGKV1-39 PTHR23267:SF402 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN KAPPA VARIABLE 1-39-RELATED response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 protein-containing complex#GO:0032991 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=10441|UniProtKB=P62241 P62241 RPS8 PTHR10394:SF12 40S RIBOSOMAL PROTEIN S8 SMALL RIBOSOMAL SUBUNIT PROTEIN ES8 translational protein#PC00263;ribosomal protein#PC00202 HUMAN|HGNC=19356|UniProtKB=Q9P299 Q9P299 COPZ2 PTHR11043:SF4 ZETA-COAT PROTEIN COATOMER SUBUNIT ZETA-2 macromolecule localization#GO:0033036;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;transport#GO:0006810;intracellular protein transport#GO:0006886;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;intra-Golgi vesicle-mediated transport#GO:0006891;localization#GO:0051179;cellular localization#GO:0051641;protein transport#GO:0015031 intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;COPI vesicle coat#GO:0030126;coated vesicle membrane#GO:0030662;Golgi-associated vesicle membrane#GO:0030660;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;coated membrane#GO:0048475;membrane coat#GO:0030117;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;coated vesicle#GO:0030135;vesicle membrane#GO:0012506;membrane#GO:0016020;COPI-coated vesicle#GO:0030137;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;vesicle coat#GO:0030120;cytoplasm#GO:0005737;Golgi-associated vesicle#GO:0005798;Golgi apparatus#GO:0005794;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090 vesicle coat protein#PC00235;membrane traffic protein#PC00150 HUMAN|HGNC=17575|UniProtKB=Q96T58 Q96T58 SPEN PTHR23189:SF48 RNA RECOGNITION MOTIF-CONTAINING MSX2-INTERACTING PROTEIN nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;RNA binding#GO:0003723 regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of mRNA processing#GO:0050684;regulation of RNA splicing#GO:0043484;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of mRNA metabolic process#GO:1903311;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of DNA-templated transcription#GO:0006355;regulation of alternative mRNA splicing, via spliceosome#GO:0000381;regulation of RNA metabolic process#GO:0051252 RNA metabolism protein#PC00031 HUMAN|HGNC=5645|UniProtKB=A0A0C4DH34 A0A0C4DH34 IGHV4-28 PTHR23266:SF361 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 4-28 antigen binding#GO:0003823;binding#GO:0005488 immunoglobulin mediated immune response#GO:0016064;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;immune effector process#GO:0002252;immune system process#GO:0002376;adaptive immune response#GO:0002250;response to stimulus#GO:0050896;immune response#GO:0006955 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=14355|UniProtKB=Q86YB8 Q86YB8 ERO1B PTHR12613:SF2 ERO1-RELATED ERO1-LIKE PROTEIN BETA oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;catalytic activity#GO:0003824;disulfide oxidoreductase activity#GO:0015036;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491;protein-disulfide reductase activity#GO:0015035 regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;signaling#GO:0023052;response to topologically incorrect protein#GO:0035966;protein folding#GO:0006457;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cellular response to stress#GO:0033554;cellular response to topologically incorrect protein#GO:0035967;cellular response to unfolded protein#GO:0034620;response to endoplasmic reticulum stress#GO:0034976;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;response to unfolded protein#GO:0006986;protein metabolic process#GO:0019538;signal transduction#GO:0007165;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;response to stress#GO:0006950;endoplasmic reticulum unfolded protein response#GO:0030968;biosynthetic process#GO:0009058;biological regulation#GO:0065007;protein maturation#GO:0051604;gene expression#GO:0010467;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170 endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HUMAN|HGNC=10328|UniProtKB=P61353 P61353 RPL27 PTHR10497:SF11 60S RIBOSOMAL PROTEIN L27 LARGE RIBOSOMAL SUBUNIT PROTEIN EL27 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 intracellular organelle#GO:0043229;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;ribosome#GO:0005840;cytosolic large ribosomal subunit#GO:0022625;cytosolic ribosome#GO:0022626;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 ribosomal protein#PC00202 HUMAN|HGNC=21290|UniProtKB=Q6ISU1 Q6ISU1 PTCRA PTHR37866:SF1 PRE T-CELL ANTIGEN RECEPTOR ALPHA PRE T-CELL ANTIGEN RECEPTOR ALPHA regulation of apoptotic process#GO:0042981;negative regulation of cellular process#GO:0048523;negative regulation of programmed cell death#GO:0043069;regulation of biological process#GO:0050789;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;negative regulation of apoptotic process#GO:0043066 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=25316|UniProtKB=Q5VZ19 Q5VZ19 TDRD10 PTHR22948:SF12 TUDOR DOMAIN CONTAINING PROTEIN TUDOR DOMAIN-CONTAINING PROTEIN 10 protein binding#GO:0005515;protein kinase A regulatory subunit binding#GO:0034237;protein kinase A binding#GO:0051018;binding#GO:0005488 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 scaffold/adaptor protein#PC00226 HUMAN|HGNC=21923|UniProtKB=Q687X5 Q687X5 STEAP4 PTHR14239:SF5 DUDULIN-RELATED METALLOREDUCTASE STEAP4 oxidoreductase activity, acting on metal ions#GO:0016722;oxidoreductase activity#GO:0016491;ferric-chelate reductase activity#GO:0000293;catalytic activity#GO:0003824 transition metal ion transport#GO:0000041;transport#GO:0006810;metal ion transport#GO:0030001;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;establishment of localization#GO:0051234 endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;intracellular vesicle#GO:0097708;cell periphery#GO:0071944;vesicle#GO:0031982;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;plasma membrane#GO:0005886 reductase#PC00198 HUMAN|HGNC=1308|UniProtKB=Q9Y3P4 Q9Y3P4 RHBDD3 PTHR43066:SF16 RHOMBOID-RELATED PROTEIN RHOMBOID DOMAIN-CONTAINING PROTEIN 3 serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233 protein modifying enzyme#PC00260;serine protease#PC00203;protease#PC00190 HUMAN|HGNC=14236|UniProtKB=Q96Q80 Q96Q80 DERL3 PTHR11009:SF4 DER1-LIKE PROTEIN, DERLIN DERLIN-3 primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;response to topologically incorrect protein#GO:0035966;signaling#GO:0023052;response to endoplasmic reticulum stress#GO:0034976;cellular response to unfolded protein#GO:0034620;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;cellular response to topologically incorrect protein#GO:0035967;cell communication#GO:0007154;response to unfolded protein#GO:0006986;protein metabolic process#GO:0019538;ERAD pathway#GO:0036503;intracellular signal transduction#GO:0035556;endoplasmic reticulum unfolded protein response#GO:0030968;response to stress#GO:0006950;signal transduction#GO:0007165;cellular process#GO:0009987;response to chemical#GO:0042221;biological regulation#GO:0065007;proteasomal protein catabolic process#GO:0010498;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170 endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 transporter#PC00227;primary active transporter#PC00068 HUMAN|HGNC=19176|UniProtKB=Q96DZ9 Q96DZ9 CMTM5 PTHR22776:SF26 MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN CKLF-LIKE MARVEL TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 5 response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;immune system process#GO:0002376;regulation of biological process#GO:0050789;immune response#GO:0006955 cellular anatomical structure#GO:0110165;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HUMAN|HGNC=1637|UniProtKB=P15813 P15813 CD1D PTHR16675:SF175 MHC CLASS I-RELATED ANTIGEN-PRESENTING GLYCOPROTEIN CD1D binding#GO:0005488;antigen binding#GO:0003823;lipid binding#GO:0008289 regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;positive regulation of leukocyte mediated immunity#GO:0002705;positive regulation of immune effector process#GO:0002699;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;positive regulation of cellular process#GO:0048522;immune response#GO:0006955;positive regulation of biological process#GO:0048518;positive regulation of immune system process#GO:0002684;regulation of leukocyte mediated cytotoxicity#GO:0001910;antigen processing and presentation#GO:0019882;regulation of immune effector process#GO:0002697;positive regulation of lymphocyte mediated immunity#GO:0002708;regulation of cell killing#GO:0031341;regulation of immune response#GO:0050776;immune system process#GO:0002376;regulation of lymphocyte mediated immunity#GO:0002706;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;positive regulation of adaptive immune response#GO:0002821;regulation of biological process#GO:0050789;regulation of leukocyte mediated immunity#GO:0002703 cell surface#GO:0009986;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;side of membrane#GO:0098552;external side of plasma membrane#GO:0009897;extracellular region#GO:0005576 major histocompatibility complex protein#PC00149;defense/immunity protein#PC00090 HUMAN|HGNC=8086|UniProtKB=P00973 P00973 OAS1 PTHR11258:SF13 2-5 OLIGOADENYLATE SYNTHETASE 2'-5'-OLIGOADENYLATE SYNTHASE 1 transferase activity, transferring phosphorus-containing groups#GO:0016772;nucleotidyltransferase activity#GO:0016779;catalytic activity#GO:0003824;transferase activity#GO:0016740;RNA binding#GO:0003723;double-stranded RNA binding#GO:0003725;adenylyltransferase activity#GO:0070566;binding#GO:0005488;nucleic acid binding#GO:0003676 response to external stimulus#GO:0009605;defense response#GO:0006952;innate immune response#GO:0045087;immune response#GO:0006955;biological regulation#GO:0065007;response to other organism#GO:0051707;cytokine-mediated signaling pathway#GO:0019221;cell communication#GO:0007154;response to virus#GO:0009615;antiviral innate immune response#GO:0140374;cellular response to stimulus#GO:0051716;response to external biotic stimulus#GO:0043207;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;defense response to symbiont#GO:0140546;signal transduction#GO:0007165;cellular process#GO:0009987;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;response to chemical#GO:0042221;response to cytokine#GO:0034097;defense response to other organism#GO:0098542;immune system process#GO:0002376;type I interferon-mediated signaling pathway#GO:0060337;response to peptide#GO:1901652;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;defense response to virus#GO:0051607;negative regulation of biological process#GO:0048519;biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052;response to stimulus#GO:0050896 nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;membrane#GO:0016020;organelle lumen#GO:0043233;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 metabolite interconversion enzyme#PC00262;nucleotidyltransferase#PC00174 HUMAN|HGNC=34491|UniProtKB=Q6ZSJ9 Q6ZSJ9 SHISA6 PTHR31774:SF0 PROTEIN SHISA-9-RELATED PROTEIN SHISA-6 signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515 regulation of signaling#GO:0023051;regulation of synaptic plasticity#GO:0048167;regulation of biological quality#GO:0065008;regulation of neuronal synaptic plasticity#GO:0048168;regulation of biological process#GO:0050789;modulation of chemical synaptic transmission#GO:0050804;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of trans-synaptic signaling#GO:0099177 synaptic membrane#GO:0097060;cell junction#GO:0030054;transporter complex#GO:1990351;neuron projection#GO:0043005;cell leading edge#GO:0031252;protein-containing complex#GO:0032991;leading edge membrane#GO:0031256;postsynaptic membrane#GO:0045211;cell projection membrane#GO:0031253;dendritic spine#GO:0043197;postsynapse#GO:0098794;cell projection#GO:0042995;neuron spine#GO:0044309;organelle#GO:0043226;cellular anatomical structure#GO:0110165;synapse#GO:0045202;signaling receptor complex#GO:0043235;neuron projection membrane#GO:0032589;cell periphery#GO:0071944;membrane#GO:0016020;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;plasma membrane region#GO:0098590;postsynaptic specialization#GO:0099572;monoatomic ion channel complex#GO:0034702;neuron to neuron synapse#GO:0098984;dendritic tree#GO:0097447;postsynaptic density#GO:0014069;dendrite#GO:0030425;transmembrane transporter complex#GO:1902495;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;plasma membrane bounded cell projection#GO:0120025;asymmetric synapse#GO:0032279 HUMAN|HGNC=3686|UniProtKB=P55075 P55075 FGF8 PTHR11486:SF3 FIBROBLAST GROWTH FACTOR FIBROBLAST GROWTH FACTOR 8 protein binding#GO:0005515;molecular function activator activity#GO:0140677;binding#GO:0005488;signaling receptor binding#GO:0005102;fibroblast growth factor receptor binding#GO:0005104;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;growth factor receptor binding#GO:0070851;growth factor activity#GO:0008083;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545 neurogenesis#GO:0022008;cellular developmental process#GO:0048869;positive regulation of MAPK cascade#GO:0043410;developmental process#GO:0032502;regulation of cell migration#GO:0030334;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;response to fibroblast growth factor#GO:0071774;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of locomotion#GO:0040012;positive regulation of response to stimulus#GO:0048584;multicellular organismal process#GO:0032501;fibroblast growth factor receptor signaling pathway#GO:0008543;regionalization#GO:0003002;positive regulation of cellular process#GO:0048522;system development#GO:0048731;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;regulation of cell motility#GO:2000145;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;pattern specification process#GO:0007389;regulation of cell communication#GO:0010646;response to growth factor#GO:0070848;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;dorsal/ventral pattern formation#GO:0009953;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;multicellular organism development#GO:0007275;regulation of MAPK cascade#GO:0043408;cell surface receptor signaling pathway#GO:0007166;nervous system development#GO:0007399;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular response to fibroblast growth factor stimulus#GO:0044344;cellular process#GO:0009987;cellular response to growth factor stimulus#GO:0071363;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;animal gross anatomical part developmental process#GO:0160108;signaling#GO:0023052;cell differentiation#GO:0030154;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;positive regulation of cell population proliferation#GO:0008284 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;extracellular region#GO:0005576 growth factor#PC00112;intercellular signal molecule#PC00207 FGF signaling pathway#P00021>FGF#P00623 HUMAN|HGNC=44449|UniProtKB=D6R901 D6R901 USP17L21 PTHR24006:SF651 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE INACTIVE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 17-LIKE PROTEIN 4-RELATED hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;cysteine-type deubiquitinase activity#GO:0004843 regulation of cellular process#GO:0050794;regulation of biological quality#GO:0065008;biological regulation#GO:0065007;regulation of programmed cell death#GO:0043067;regulation of apoptotic process#GO:0042981;regulation of biological process#GO:0050789;regulation of protein stability#GO:0031647 cytosol#GO:0005829;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 protease#PC00190;cysteine protease#PC00081 HUMAN|HGNC=2583|UniProtKB=Q14093 Q14093 CYLC2 PTHR16742:SF2 CYCLICIN CYLICIN-2 structural protein#PC00211 HUMAN|HGNC=18481|UniProtKB=Q9Y487 Q9Y487 ATP6V0A2 PTHR11629:SF22 VACUOLAR PROTON ATPASES V-TYPE PROTON ATPASE 116 KDA SUBUNIT A 2 protein binding#GO:0005515;monoatomic cation transmembrane transporter activity#GO:0008324;binding#GO:0005488;ATPase-coupled transmembrane transporter activity#GO:0042626;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATP-dependent activity#GO:0140657;enzyme binding#GO:0019899;monoatomic ion transmembrane transporter activity#GO:0015075;active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399;proton transmembrane transporter activity#GO:0015078;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;chemical homeostasis#GO:0048878;metabolic process#GO:0008152;monoatomic cation transmembrane transport#GO:0098655;autophagy#GO:0006914;cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;process utilizing autophagic mechanism#GO:0061919;cellular component disassembly#GO:0022411;transmembrane transport#GO:0055085;intracellular monoatomic ion homeostasis#GO:0006873;cellular component organization#GO:0016043;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;proton transmembrane transport#GO:1902600;vacuolar acidification#GO:0007035;establishment of localization#GO:0051234;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;transport#GO:0006810;autophagosome maturation#GO:0097352;biological regulation#GO:0065007;macroautophagy#GO:0016236;monoatomic ion transmembrane transport#GO:0034220;localization#GO:0051179;monoatomic cation transport#GO:0006812;regulation of intracellular pH#GO:0051453;regulation of pH#GO:0006885;homeostatic process#GO:0042592;protein-containing complex disassembly#GO:0032984;catabolic process#GO:0009056 cation-transporting ATPase complex#GO:0090533;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;ATPase complex#GO:1904949;vacuolar proton-transporting V-type ATPase complex#GO:0016471;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ATPase dependent transmembrane transport complex#GO:0098533;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;membrane#GO:0016020;cytoplasm#GO:0005737;vacuole#GO:0005773;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;proton-transporting two-sector ATPase complex#GO:0016469;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;proton-transporting V-type ATPase complex#GO:0033176;vacuolar membrane#GO:0005774;transporter complex#GO:1990351 ATP synthase#PC00002 HUMAN|HGNC=25654|UniProtKB=Q86YA3 Q86YA3 ZGRF1 PTHR28535:SF1 ZINC FINGER GRF-TYPE CONTAINING 1 5'-3' DNA HELICASE ZGRF1 double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;nucleobase-containing compound metabolic process#GO:0006139;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;primary metabolic process#GO:0044238;response to stress#GO:0006950;nucleic acid metabolic process#GO:0090304 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;site of DNA damage#GO:0090734;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;site of double-strand break#GO:0035861;chromosome#GO:0005694;nucleus#GO:0005634 HUMAN|HGNC=26757|UniProtKB=A6NC98 A6NC98 CCDC88B PTHR18947:SF35 HOOK PROTEINS COILED-COIL DOMAIN-CONTAINING PROTEIN 88B cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;microtubule binding#GO:0008017;binding#GO:0005488;protein binding#GO:0005515 establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;intracellular transport#GO:0046907;transport#GO:0006810;cytoskeleton-dependent intracellular transport#GO:0030705;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;cellular localization#GO:0051641;microtubule cytoskeleton organization#GO:0000226;localization#GO:0051179;supramolecular fiber organization#GO:0097435;cytoplasmic microtubule organization#GO:0031122;cellular component organization#GO:0016043 intracellular organelle#GO:0043229;centrosome#GO:0005813;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 membrane traffic protein#PC00150 HUMAN|HGNC=49389|UniProtKB=E9PQX1 E9PQX1 CATSPERH PTHR37998:SF1 TRANSMEMBRANE PROTEIN 262 CATION CHANNEL SPERM-ASSOCIATED AUXILIARY SUBUNIT ETA HUMAN|HGNC=28607|UniProtKB=Q8N6M8 Q8N6M8 IQCF1 PTHR21633:SF14 IQ MOTIF CONTAINING F IQ DOMAIN-CONTAINING PROTEIN F1 protein binding#GO:0005515;calmodulin binding#GO:0005516;binding#GO:0005488 regulation of cell motility#GO:2000145;anatomical structure development#GO:0048856;multicellular organismal reproductive process#GO:0048609;regulation of microtubule-based process#GO:0032886;sexual reproduction#GO:0019953;spermatid development#GO:0007286;regulation of cellular process#GO:0050794;reproductive process#GO:0022414;developmental process involved in reproduction#GO:0003006;anatomical structure maturation#GO:0071695;germ cell development#GO:0007281;cell maturation#GO:0048469;cellular developmental process#GO:0048869;positive regulation of locomotion#GO:0040017;developmental process#GO:0032502;spermatogenesis#GO:0007283;regulation of reproductive process#GO:2000241;developmental maturation#GO:0021700;male gamete generation#GO:0048232;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;positive regulation of cellular process#GO:0048522;spermatid differentiation#GO:0048515;regulation of microtubule-based movement#GO:0060632;cell differentiation#GO:0030154;gamete generation#GO:0007276;cellular process involved in reproduction in multicellular organism#GO:0022412;cell development#GO:0048468;positive regulation of cell motility#GO:2000147;regulation of biological process#GO:0050789;sperm capacitation#GO:0048240;positive regulation of biological process#GO:0048518;cellular process#GO:0009987 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;vesicle#GO:0031982;intracellular vesicle#GO:0097708;secretory vesicle#GO:0099503;membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;acrosomal vesicle#GO:0001669 HUMAN|HGNC=11105|UniProtKB=Q8TAQ2 Q8TAQ2 SMARCC2 PTHR12802:SF105 SWI/SNF COMPLEX-RELATED SWI_SNF COMPLEX SUBUNIT SMARCC2 protein binding#GO:0005515;binding#GO:0005488;histone binding#GO:0042393 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789 nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;chromatin#GO:0000785;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;SWI/SNF complex#GO:0016514;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ATPase complex#GO:1904949;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;chromosome#GO:0005694;SWI/SNF superfamily-type complex#GO:0070603;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 chromatin/chromatin-binding, or -regulatory protein#PC00077 Wnt signaling pathway#P00057>SWI/SNF#P01435 HUMAN|HGNC=2567|UniProtKB=O75665 O75665 OFD1 PTHR15431:SF14 FGFR1 ONCOGENE PARTNER/LISH DOMAIN-CONTAINING PROTEIN CENTRIOLE AND CENTRIOLAR SATELLITE PROTEIN OFD1 plasma membrane bounded cell projection assembly#GO:0120031;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782;cellular component organization#GO:0016043;cilium assembly#GO:0060271;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cell projection assembly#GO:0030031;cell projection organization#GO:0030030;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036 centrosome#GO:0005813;microtubule organizing center#GO:0005815;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cilium#GO:0005929;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;motile cilium#GO:0031514;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025 HUMAN|HGNC=10331|UniProtKB=P47914 P47914 RPL29 PTHR12884:SF23 60S RIBOSOMAL PROTEIN L29 LARGE RIBOSOMAL SUBUNIT PROTEIN EL29 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 translation#GO:0006412;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;cytoplasmic translation#GO:0002181;protein biosynthetic process#GO:0160307;gene expression#GO:0010467 ribosome#GO:0005840;cytosol#GO:0005829;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 ribosomal protein#PC00202 HUMAN|HGNC=198|UniProtKB=Q99965 Q99965 ADAM2 PTHR11905:SF108 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 2 metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 reproductive structure development#GO:0048608;reproductive process#GO:0022414;fertilization#GO:0009566;developmental process involved in reproduction#GO:0003006;primary metabolic process#GO:0044238;reproductive system development#GO:0061458;system development#GO:0048731;anatomical structure development#GO:0048856;protein metabolic process#GO:0019538;binding of sperm to zona pellucida#GO:0007339;cell recognition#GO:0008037;cell adhesion#GO:0007155;sexual reproduction#GO:0019953;animal gross anatomical part developmental process#GO:0160108;proteolysis#GO:0006508;gonad development#GO:0008406;multicellular organismal process#GO:0032501;sex differentiation#GO:0007548;cellular process#GO:0009987;male gonad development#GO:0008584;single fertilization#GO:0007338;cell-cell recognition#GO:0009988;animal organ development#GO:0048513;macromolecule metabolic process#GO:0043170;multicellular organism development#GO:0007275;male sex differentiation#GO:0046661;developmental process#GO:0032502;development of primary sexual characteristics#GO:0045137;sperm-egg recognition#GO:0035036;metabolic process#GO:0008152;development of primary male sexual characteristics#GO:0046546 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 metalloprotease#PC00153;protease#PC00190 HUMAN|HGNC=21211|UniProtKB=Q9BWV7 Q9BWV7 TTLL2 PTHR12241:SF118 TUBULIN POLYGLUTAMYLASE TUBULIN POLYGLUTAMYLASE TTLL2-RELATED catalytic activity, acting on a protein#GO:0140096;ligase activity#GO:0016874;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;catalytic activity#GO:0003824;ligase activity, forming carbon-nitrogen bonds#GO:0016879;protein binding#GO:0005515;binding#GO:0005488 microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987 microtubule organizing center#GO:0005815;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;cilium#GO:0005929;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;microtubule cytoskeleton#GO:0015630;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;plasma membrane bounded cell projection#GO:0120025 microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=26496|UniProtKB=A8K8V0 A8K8V0 ZNF785 PTHR24381:SF297 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 785 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=10409|UniProtKB=P63220 P63220 RPS21 PTHR10442:SF24 40S RIBOSOMAL PROTEIN S21 SMALL RIBOSOMAL SUBUNIT PROTEIN ES21 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;RNA metabolic process#GO:0016070;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;maturation of 5.8S rRNA#GO:0000460;ribonucleoprotein complex biogenesis#GO:0022613;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;cytoplasmic translation#GO:0002181;protein biosynthetic process#GO:0160307;ribosomal small subunit biogenesis#GO:0042274;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA 3'-end processing#GO:0031123;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000479;RNA processing#GO:0006396;maturation of SSU-rRNA#GO:0030490;gene expression#GO:0010467;translation#GO:0006412;rRNA processing#GO:0006364;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000447;rRNA metabolic process#GO:0016072;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;cytosolic small ribosomal subunit#GO:0022627;intracellular organelle#GO:0043229;small ribosomal subunit#GO:0015935;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytosolic ribosome#GO:0022626;cytosol#GO:0005829;ribosome#GO:0005840 ribosomal protein#PC00202;translational protein#PC00263 HUMAN|HGNC=8614|UniProtKB=Q96IZ0 Q96IZ0 PAWR PTHR15093:SF1 PROSTATE APOPTOSIS RESPONSE PROTEIN PAR-4 PRKC APOPTOSIS WT1 REGULATOR PROTEIN regulation of neuron apoptotic process#GO:0043523;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;positive regulation of neuron apoptotic process#GO:0043525;regulation of apoptotic process#GO:0042981;positive regulation of apoptotic process#GO:0043065;apoptotic signaling pathway#GO:0097190;regulation of programmed cell death#GO:0043067;programmed cell death#GO:0012501;regulation of biological process#GO:0050789;apoptotic process#GO:0006915;cellular response to stimulus#GO:0051716;cell death#GO:0008219;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;positive regulation of programmed cell death#GO:0043068;signaling#GO:0023052;cell communication#GO:0007154 nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=11882|UniProtKB=O14604 O14604 TMSB4Y PTHR12021:SF18 THYMOSIN BETA THYMOSIN BETA-4, Y-CHROMOSOMAL molecular sequestering activity#GO:0140313;binding#GO:0005488;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;protein sequestering activity#GO:0140311;actin monomer binding#GO:0003785;protein binding#GO:0005515 regulation of biological process#GO:0050789;regulation of cell migration#GO:0030334;regulation of cell motility#GO:2000145;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of locomotion#GO:0040012 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=20466|UniProtKB=Q96SB8 Q96SB8 SMC6 PTHR19306:SF6 STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6 STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6 damaged DNA binding#GO:0003684;single-stranded DNA binding#GO:0003697;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA binding#GO:0003677 cellular process#GO:0009987;response to stress#GO:0006950;nucleobase-containing compound metabolic process#GO:0006139;DNA damage response#GO:0006974;DNA recombination#GO:0006310;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;double-strand break repair via homologous recombination#GO:0000724;cellular response to stimulus#GO:0051716;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;recombinational repair#GO:0000725 chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;site of DNA damage#GO:0090734;nucleus#GO:0005634;site of double-strand break#GO:0035861;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;transferase complex#GO:1990234;condensed chromosome#GO:0000793;membraneless organelle#GO:0043228 DNA metabolism protein#PC00009 HUMAN|HGNC=3474|UniProtKB=P62508 P62508 ESRRG PTHR48092:SF10 KNIRPS-RELATED PROTEIN-RELATED ESTROGEN-RELATED RECEPTOR GAMMA sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;molecular transducer activity#GO:0060089;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;nuclear receptor activity#GO:0004879 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694 C4 zinc finger nuclear receptor#PC00169;zinc finger transcription factor#PC00244 HUMAN|HGNC=10545|UniProtKB=Q15800 Q15800 MSMO1 PTHR11863:SF225 STEROL DESATURASE METHYLSTEROL MONOOXYGENASE 1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;monooxygenase activity#GO:0004497;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 lipid biosynthetic process#GO:0008610;cholesterol biosynthetic process#GO:0006695;steroid metabolic process#GO:0008202;biosynthetic process#GO:0009058;sterol biosynthetic process#GO:0016126;cellular process#GO:0009987;alcohol biosynthetic process#GO:0046165;sterol metabolic process#GO:0016125;steroid biosynthetic process#GO:0006694;secondary alcohol biosynthetic process#GO:1902653;alcohol metabolic process#GO:0006066;metabolic process#GO:0008152;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;cholesterol metabolic process#GO:0008203;small molecule metabolic process#GO:0044281;secondary alcohol metabolic process#GO:1902652;primary metabolic process#GO:0044238 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827 oxidase#PC00175 HUMAN|HGNC=3243|UniProtKB=Q9NZN4 Q9NZN4 EHD2 PTHR11216:SF62 EH DOMAIN EH DOMAIN-CONTAINING PROTEIN 2 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 transport#GO:0006810;intracellular transport#GO:0046907;plasma membrane bounded cell projection assembly#GO:0120031;protein localization to cell periphery#GO:1990778;intracellular protein localization#GO:0008104;vesicle-mediated transport to the plasma membrane#GO:0098876;endosomal transport#GO:0016197;import into cell#GO:0098657;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cell projection assembly#GO:0030031;establishment of localization in cell#GO:0051649;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;macromolecule localization#GO:0033036;plasma membrane bounded cell projection organization#GO:0120036;vesicle-mediated transport#GO:0016192;cellular component assembly#GO:0022607;localization within membrane#GO:0051668;organelle assembly#GO:0070925;cilium organization#GO:0044782;cellular localization#GO:0051641;localization#GO:0051179;cellular component organization#GO:0016043;protein localization to plasma membrane#GO:0072659;cilium assembly#GO:0060271;protein localization to membrane#GO:0072657;endocytosis#GO:0006897;endocytic recycling#GO:0032456;cell projection organization#GO:0030030 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;endocytic vesicle#GO:0030139;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768;endosome membrane#GO:0010008;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;perinuclear region of cytoplasm#GO:0048471;plasma membrane#GO:0005886;cytoplasm#GO:0005737;vesicle membrane#GO:0012506;membrane#GO:0016020;cell periphery#GO:0071944;bounding membrane of organelle#GO:0098588;recycling endosome membrane#GO:0055038;organelle membrane#GO:0031090;recycling endosome#GO:0055037 membrane traffic protein#PC00150 HUMAN|HGNC=32434|UniProtKB=A6NNN8 A6NNN8 SLC38A8 PTHR22950:SF226 AMINO ACID TRANSPORTER SOLUTE CARRIER FAMILY 38 MEMBER 8 L-amino acid transmembrane transporter activity#GO:0015179;amino acid transmembrane transporter activity#GO:0015171;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943 amino acid transmembrane transport#GO:0003333;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;cellular process#GO:0009987;transport#GO:0006810;amino acid transport#GO:0006865 cellular anatomical structure#GO:0110165;membrane#GO:0016020 amino acid transporter#PC00046;secondary carrier transporter#PC00258 HUMAN|HGNC=17031|UniProtKB=Q8WTQ7 Q8WTQ7 GRK7 PTHR24355:SF12 G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE RHODOPSIN KINASE GRK7 transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;regulation of biological process#GO:0050789;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 non-receptor serine/threonine protein kinase#PC00167 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GPRK#P00741;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GPRK#P00701 HUMAN|HGNC=18909|UniProtKB=Q9BYQ5 Q9BYQ5 KRTAP4-6 PTHR23262:SF248 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 4-6 structural protein#PC00211 HUMAN|HGNC=13831|UniProtKB=Q9BZH6 Q9BZH6 WDR11 PTHR14593:SF5 WD REPEAT-CONTAINING PROTEIN 11 WD REPEAT-CONTAINING PROTEIN 11 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=17509|UniProtKB=Q9BXL5 Q9BXL5 HEMGN PTHR15993:SF6 HEMOGEN HEMOGEN regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of developmental process#GO:0050793;regulation of biological process#GO:0050789;regulation of cell differentiation#GO:0045595 organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=32979|UniProtKB=Q99871 Q99871 HAUS7 PTHR14352:SF2 HAUS AUGMIN-LIKE COMPLEX SUBUNIT 7 HAUS AUGMIN-LIKE COMPLEX SUBUNIT 7 protein binding#GO:0005515;binding#GO:0005488;microtubule binding#GO:0008017;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092 chromosome segregation#GO:0007059;microtubule-based process#GO:0007017;microtubule organizing center organization#GO:0031023;cellular component organization or biogenesis#GO:0071840;spindle organization#GO:0007051;cellular process#GO:0009987;spindle assembly#GO:0051225;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;organelle assembly#GO:0070925;microtubule cytoskeleton organization#GO:0000226;cell cycle process#GO:0022402;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;cell cycle#GO:0007049 organelle#GO:0043226;microtubule associated complex#GO:0005875;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;HAUS complex#GO:0070652;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 Ubiquitin proteasome pathway#P00060>26S proteasome#P01489 HUMAN|HGNC=11648|UniProtKB=P56279 P56279 TCL1A PTHR14060:SF4 PROTEIN P13 MTCP-1 T-CELL LEUKEMIA_LYMPHOMA PROTEIN 1A molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;protein kinase regulator activity#GO:0019887;protein serine/threonine kinase activator activity#GO:0043539;enzyme activator activity#GO:0008047;protein kinase activator activity#GO:0030295;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;kinase activator activity#GO:0019209 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=240|UniProtKB=O60503 O60503 ADCY9 PTHR45627:SF8 ADENYLATE CYCLASE TYPE 1 ADENYLATE CYCLASE TYPE 9 catalytic activity#GO:0003824;phosphorus-oxygen lyase activity#GO:0016849;cyclase activity#GO:0009975;lyase activity#GO:0016829;adenylate cyclase activity#GO:0004016 primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;nucleoside phosphate metabolic process#GO:0006753;organophosphate biosynthetic process#GO:0090407;cell communication#GO:0007154;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;carbohydrate derivative metabolic process#GO:1901135;biosynthetic process#GO:0009058;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cyclic nucleotide metabolic process#GO:0009187;nucleoside phosphate biosynthetic process#GO:1901293;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521;regulation of biological process#GO:0050789;purine nucleotide metabolic process#GO:0006163;response to stimulus#GO:0050896;small molecule metabolic process#GO:0044281;signaling#GO:0023052;ribonucleotide metabolic process#GO:0009259;G protein-coupled receptor signaling pathway#GO:0007186;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;cyclic nucleotide biosynthetic process#GO:0009190;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;nucleotide biosynthetic process#GO:0009165;ribose phosphate biosynthetic process#GO:0046390;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;signal transduction#GO:0007165;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;cyclic purine nucleotide metabolic process#GO:0052652;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 adenylate cyclase#PC00043 GABA-B receptor II signaling#P05731>AC#P05760;Endothelin signaling pathway#P00019>Adenylate cyclase#P00569;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>cAMP cyclase#P00719 HUMAN|HGNC=30046|UniProtKB=Q96BK5 Q96BK5 PINX1 PTHR23149:SF27 G PATCH DOMAIN CONTAINING PROTEIN PIN2_TERF1-INTERACTING TELOMERASE INHIBITOR 1 enzyme inhibitor activity#GO:0004857;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;molecular function inhibitor activity#GO:0140678 membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular organelle#GO:0043229;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 RNA metabolism protein#PC00031 HUMAN|HGNC=16637|UniProtKB=Q9BUP3 Q9BUP3 HTATIP2 PTHR14097:SF7 OXIDOREDUCTASE HTATIP2 PROTEIN HTATIP2 catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674 positive regulation of programmed cell death#GO:0043068;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of programmed cell death#GO:0043067;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 oxidoreductase#PC00176 HUMAN|HGNC=29595|UniProtKB=Q6UW15 Q6UW15 REG3G PTHR22803:SF116 MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED REGENERATING ISLET-DERIVED PROTEIN 3-GAMMA molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;hormone activity#GO:0005179;molecular function activator activity#GO:0140677;growth factor activity#GO:0008083;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018 regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;positive regulation of cell population proliferation#GO:0008284;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;response to oxygen-containing compound#GO:1901700;immune system process#GO:0002376;response to nitrogen compound#GO:1901698;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;regulation of cell population proliferation#GO:0042127;positive regulation of cellular process#GO:0048522;immune response#GO:0006955;positive regulation of biological process#GO:0048518;defense response to symbiont#GO:0140546;response to stress#GO:0006950;response to hormone#GO:0009725;response to biotic stimulus#GO:0009607;response to other organism#GO:0051707;response to peptide hormone#GO:0043434;biological regulation#GO:0065007;defense response to other organism#GO:0098542;response to chemical#GO:0042221;humoral immune response#GO:0006959;antimicrobial humoral response#GO:0019730;defense response#GO:0006952;response to external stimulus#GO:0009605 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=9283|UniProtKB=P36873 P36873 PPP1CC PTHR11668:SF204 SERINE/THREONINE PROTEIN PHOSPHATASE SERINE_THREONINE-PROTEIN PHOSPHATASE PP1-GAMMA CATALYTIC SUBUNIT catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721 cell differentiation#GO:0030154;regulation of biological process#GO:0050789;anatomical structure development#GO:0048856;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;biological regulation#GO:0065007;cellular process#GO:0009987;regulation of circadian rhythm#GO:0042752;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;neurogenesis#GO:0022008;developmental process#GO:0032502;neuron differentiation#GO:0030182 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 protein phosphatase#PC00195 Nicotine pharmacodynamics pathway#P06587>PPP1CA#P06602;Dopamine receptor mediated signaling pathway#P05912>Protein Phosphatase-1#P05969 HUMAN|HGNC=13843|UniProtKB=A6NFI3 A6NFI3 ZNF316 PTHR24408:SF54 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 316 nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific DNA binding#GO:0043565 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=11006|UniProtKB=P11168 P11168 SLC2A2 PTHR23503:SF27 SOLUTE CARRIER FAMILY 2 SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 2 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;sugar transmembrane transporter activity#GO:0051119;carbohydrate transmembrane transporter activity#GO:0015144 transport#GO:0006810;carbohydrate transport#GO:0008643;import into cell#GO:0098657;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;cellular process#GO:0009987;D-glucose transmembrane transport#GO:1904659;vitamin transport#GO:0051180;carbohydrate transmembrane transport#GO:0034219;import across plasma membrane#GO:0098739 membrane#GO:0016020;brush border#GO:0005903;cell periphery#GO:0071944;apical part of cell#GO:0045177;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cluster of actin-based cell projections#GO:0098862 secondary carrier transporter#PC00258 HUMAN|HGNC=18672|UniProtKB=Q96SN8 Q96SN8 CDK5RAP2 PTHR46930:SF1 CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 2 CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 2 protein binding#GO:0005515;microtubule binding#GO:0008017;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631 cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;regulation of sister chromatid segregation#GO:0033045;establishment or maintenance of cell polarity#GO:0007163;regulation of intracellular signal transduction#GO:1902531;regulation of mitotic cell cycle phase transition#GO:1901990;spindle localization#GO:0051653;establishment of mitotic spindle localization#GO:0040001;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;regulation of cell cycle process#GO:0010564;chromosome segregation#GO:0007059;regulation of chromosome segregation#GO:0051983;negative regulation of cell cycle#GO:0045786;microtubule organizing center organization#GO:0031023;establishment of spindle orientation#GO:0051294;microtubule-based process#GO:0007017;negative regulation of cellular component organization#GO:0051129;microtubule cytoskeleton organization involved in mitosis#GO:1902850;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;mitotic cell cycle#GO:0000278;regulation of cytoskeleton organization#GO:0051493;organelle assembly#GO:0070925;organelle localization#GO:0051640;centriole replication#GO:0007099;localization#GO:0051179;negative regulation of cytoskeleton organization#GO:0051494;microtubule cytoskeleton organization#GO:0000226;regulation of organelle assembly#GO:1902115;regulation of mitotic cell cycle#GO:0007346;regulation of signal transduction#GO:0009966;regulation of nuclear division#GO:0051783;regulation of chromosome organization#GO:0033044;negative regulation of cell cycle process#GO:0010948;establishment of mitotic spindle orientation#GO:0000132;regulation of mitotic sister chromatid separation#GO:0010965;establishment of localization#GO:0051234;regulation of mitotic nuclear division#GO:0007088;negative regulation of biological process#GO:0048519;centrosome cycle#GO:0007098;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;cell cycle process#GO:0022402;regulation of cellular component organization#GO:0051128;establishment of organelle localization#GO:0051656;regulation of cell cycle#GO:0051726;regulation of cellular component biogenesis#GO:0044087;regulation of signaling#GO:0023051;cellular localization#GO:0051641;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;regulation of chromosome separation#GO:1905818;cellular component organization or biogenesis#GO:0071840;centrosome duplication#GO:0051298;cell cycle#GO:0007049;regulation of cell cycle phase transition#GO:1901987;negative regulation of organelle organization#GO:0010639;establishment of cell polarity#GO:0030010;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of microtubule-based process#GO:0032886;microtubule bundle formation#GO:0001578;regulation of mitotic sister chromatid segregation#GO:0033047;establishment of spindle localization#GO:0051293;regulation of mitotic metaphase/anaphase transition#GO:0030071;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;mitotic cell cycle process#GO:1903047 supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;intracellular organelle#GO:0043229;mitotic spindle#GO:0072686;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microtubule end#GO:1990752;spindle pole#GO:0000922;microtubule plus-end#GO:0035371;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;microtubule organizing center#GO:0005815;centrosome#GO:0005813;spindle#GO:0005819;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;microtubule cytoskeleton#GO:0015630;mitotic spindle pole#GO:0097431 HUMAN|HGNC=28441|UniProtKB=Q8TAK5 Q8TAK5 GABPB2 PTHR24193:SF86 ANKYRIN REPEAT PROTEIN GA-BINDING PROTEIN SUBUNIT BETA-2 DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of DNA-templated transcription#GO:0006355;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=27014|UniProtKB=Q8N1E2 Q8N1E2 LYG1 PTHR31698:SF5 LYSOZYME G FAMILY MEMBER LYSOZYME G-LIKE PROTEIN 1 peptidoglycan muralytic activity#GO:0061783;catalytic activity#GO:0003824;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;lysozyme activity#GO:0003796 response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to other organism#GO:0051707;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;defense response to Gram-positive bacterium#GO:0050830;response to external stimulus#GO:0009605;defense response#GO:0006952;response to bacterium#GO:0009617;defense response to bacterium#GO:0042742 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=16397|UniProtKB=Q9BXB4 Q9BXB4 OSBPL11 PTHR10972:SF46 OXYSTEROL-BINDING PROTEIN-RELATED OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 11 steroid binding#GO:0005496;lipid binding#GO:0008289;binding#GO:0005488;sterol binding#GO:0032934 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytosol#GO:0005829;membrane#GO:0016020 transfer/carrier protein#PC00219 HUMAN|HGNC=7373|UniProtKB=P26038 P26038 MSN PTHR23281:SF26 MERLIN/MOESIN/EZRIN/RADIXIN MOESIN binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;cell adhesion molecule binding#GO:0050839;protein binding#GO:0005515 regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of developmental process#GO:0050793;regulation of cellular component biogenesis#GO:0044087;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;regulation of cell shape#GO:0008360;regulation of protein localization#GO:0032880;regulation of biological quality#GO:0065008;biological regulation#GO:0065007;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of transport#GO:0051050;regulation of organelle assembly#GO:1902115;regulation of anatomical structure morphogenesis#GO:0022603;regulation of localization#GO:0032879;regulation of transport#GO:0051049 intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;intracellular organelle#GO:0043229;filopodium#GO:0030175;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;actin-based cell projection#GO:0098858;microvillus#GO:0005902;actin cytoskeleton#GO:0015629;adherens junction#GO:0005912;membraneless organelle#GO:0043228;cell junction#GO:0030054;apical part of cell#GO:0045177;cytoskeleton#GO:0005856;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;cell periphery#GO:0071944;cell-cell junction#GO:0005911;membrane#GO:0016020 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=18549|UniProtKB=Q9H295 Q9H295 DCSTAMP PTHR21041:SF2 DENDRITIC CELL-SPECIFIC TRANSMEMBRANE PROTEIN DENDRITIC CELL-SPECIFIC TRANSMEMBRANE PROTEIN cell-cell fusion#GO:0140253;sexual reproduction#GO:0019953;anatomical structure development#GO:0048856;syncytium formation by cell-cell fusion#GO:0000768;osteoclast differentiation#GO:0030316;leukocyte differentiation#GO:0002521;myeloid cell differentiation#GO:0030099;cell differentiation#GO:0030154;fertilization#GO:0009566;cell development#GO:0048468;reproductive process#GO:0022414;developmental process#GO:0032502;cellular developmental process#GO:0048869;single fertilization#GO:0007338;cellular process#GO:0009987;hemopoiesis#GO:0030097 endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;membrane#GO:0016020;cytoplasm#GO:0005737;cell surface#GO:0009986;endomembrane system#GO:0012505;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165 HUMAN|HGNC=10440|UniProtKB=P62081 P62081 RPS7 PTHR11278:SF5 40S RIBOSOMAL PROTEIN S7 SMALL RIBOSOMAL SUBUNIT PROTEIN ES7 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;ribosomal small subunit biogenesis#GO:0042274;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840 organelle lumen#GO:0043233;cytosolic ribosome#GO:0022626;ribosome#GO:0005840;small-subunit processome#GO:0032040;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;nucleolus#GO:0005730;cytosolic small ribosomal subunit#GO:0022627;preribosome#GO:0030684;intracellular organelle#GO:0043229;small ribosomal subunit#GO:0015935;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228 ribosomal protein#PC00202 HUMAN|HGNC=27322|UniProtKB=Q86W54 Q86W54 SPATA24 PTHR35155:SF1 SPERMATOGENESIS-ASSOCIATED PROTEIN 24 SPERMATOGENESIS-ASSOCIATED PROTEIN 24 binding#GO:0005488;nucleic acid binding#GO:0003676;DNA binding#GO:0003677 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HUMAN|HGNC=24866|UniProtKB=O60308 O60308 CEP104 PTHR13371:SF0 GLYCINE-, GLUTAMATE-, THIENYLCYCLOHEXYLPIPERIDINE-BINDING PROTEIN CENTROSOMAL PROTEIN OF 104 KDA cilium#GO:0005929;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025 HUMAN|HGNC=12738|UniProtKB=Q969T9 Q969T9 WBP2 PTHR31606:SF4 WW DOMAIN BINDING PROTEIN 2, ISOFORM E WW DOMAIN-BINDING PROTEIN 2 DNA binding#GO:0003677;nucleic acid binding#GO:0003676;binding#GO:0005488;chromatin binding#GO:0003682;transcription regulator activity#GO:0140110;transcription coactivator activity#GO:0003713;transcription coregulator activity#GO:0003712;chromatin DNA binding#GO:0031490 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=1487|UniProtKB=Q13938 Q13938 CAPS PTHR34524:SF2 CALCYPHOSIN CALCYPHOSIN calmodulin-related#PC00061;calcium-binding protein#PC00060 HUMAN|HGNC=9768|UniProtKB=P51157 P51157 RAB28 PTHR24073:SF572 DRAB5-RELATED RAS-RELATED PROTEIN RAB-28 ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462 cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;protein transport#GO:0015031;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 G-protein#PC00020;small GTPase#PC00208 HUMAN|HGNC=16104|UniProtKB=Q8IXH6 Q8IXH6 TP53INP2 PTHR31671:SF2 DIABETES AND OBESITY REGULATED, ISOFORM G TUMOR PROTEIN P53-INDUCIBLE NUCLEAR PROTEIN 2 protein-membrane adaptor activity#GO:0043495;transcription coactivator activity#GO:0003713;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;macroautophagy#GO:0016236;organelle assembly#GO:0070925;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;vacuole organization#GO:0007033;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;autophagosome assembly#GO:0000045;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;autophagy#GO:0006914;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;autophagosome organization#GO:1905037;cellular component assembly#GO:0022607;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;process utilizing autophagic mechanism#GO:0061919;cellular component organization#GO:0016043;regulation of biological process#GO:0050789 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;vacuole#GO:0005773;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;autophagosome#GO:0005776 HUMAN|HGNC=2228|UniProtKB=P21964 P21964 COMT PTHR43836:SF3 CATECHOL O-METHYLTRANSFERASE 1-RELATED CATECHOL O-METHYLTRANSFERASE transferase activity, transferring one-carbon groups#GO:0016741;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;catalytic activity#GO:0003824;transferase activity#GO:0016740;O-methyltransferase activity#GO:0008171 biogenic amine metabolic process#GO:0006576;catabolic process#GO:0009056;phenol-containing compound metabolic process#GO:0018958;cellular process#GO:0009987;amine metabolic process#GO:0009308;catecholamine metabolic process#GO:0006584;amine catabolic process#GO:0009310;metabolic process#GO:0008152 axon#GO:0030424;dendritic tree#GO:0097447;dendrite#GO:0030425;neuron projection#GO:0043005;membrane#GO:0016020;cell projection#GO:0042995;somatodendritic compartment#GO:0036477;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165 methyltransferase#PC00155 Adrenaline and noradrenaline biosynthesis#P00001>COMT#P00069;Dopamine receptor mediated signaling pathway#P05912>COMT#P05944 HUMAN|HGNC=11844|UniProtKB=Q9Y6L7 Q9Y6L7 TLL2 PTHR10127:SF866 DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING TOLLOID-LIKE PROTEIN 2 catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;metalloendopeptidase activity#GO:0004222;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein processing#GO:0016485;biosynthetic process#GO:0009058;gene expression#GO:0010467;regionalization#GO:0003002;multicellular organismal process#GO:0032501;protein maturation#GO:0051604;developmental process#GO:0032502;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;multicellular organism development#GO:0007275;dorsal/ventral pattern formation#GO:0009953;primary metabolic process#GO:0044238;pattern specification process#GO:0007389;proteolysis#GO:0006508;protein metabolic process#GO:0019538;anatomical structure development#GO:0048856 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 metalloprotease#PC00153;protease#PC00190 TGF-beta signaling pathway#P00052>TGFbeta#P01286 HUMAN|HGNC=18421|UniProtKB=Q9H9G7 Q9H9G7 AGO3 PTHR22891:SF3 EUKARYOTIC TRANSLATION INITIATION FACTOR 2C PROTEIN ARGONAUTE-3 endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;single-stranded RNA binding#GO:0003727;catalytic activity, acting on RNA#GO:0140098;RNA endonuclease activity#GO:0004521;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;RNA binding#GO:0003723;nuclease activity#GO:0004518;binding#GO:0005488;nucleic acid binding#GO:0003676 RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;miRNA processing#GO:0035196;negative regulation of metabolic process#GO:0009892;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;regulatory ncRNA-mediated post-transcriptional gene silencing#GO:0035194;post-transcriptional gene silencing#GO:0016441;RNA biosynthetic process#GO:0032774;regulation of macromolecule metabolic process#GO:0060255;pre-miRNA processing#GO:0031054;regulation of cellular process#GO:0050794;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;regulatory ncRNA processing#GO:0070918;regulation of biosynthetic process#GO:0009889;regulatory ncRNA-mediated gene silencing#GO:0031047;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;negative regulation of macromolecule metabolic process#GO:0010605;macromolecule biosynthetic process#GO:0009059;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;supramolecular complex#GO:0099080;organelle#GO:0043226;ribonucleoprotein granule#GO:0035770 translation factor#PC00223;translation initiation factor#PC00224;translational protein#PC00263 HUMAN|HGNC=1356|UniProtKB=O94905 O94905 ERLIN2 PTHR15351:SF4 ERLIN (ER LIPID RAFT ASSOCIATED PROTEIN) HOMOLOG ERLIN-2 signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;catabolic process#GO:0009056;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;primary metabolic process#GO:0044238;intracellular signal transduction#GO:0035556;ERAD pathway#GO:0036503;protein metabolic process#GO:0019538;cell communication#GO:0007154;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;response to endoplasmic reticulum stress#GO:0034976;SREBP signaling pathway#GO:0032933;proteasomal protein catabolic process#GO:0010498;biological regulation#GO:0065007;response to chemical#GO:0042221;cellular process#GO:0009987;signal transduction#GO:0007165;response to stress#GO:0006950;macromolecule metabolic process#GO:0043170;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152 membrane#GO:0016020;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984 HUMAN|HGNC=29333|UniProtKB=Q8N2N9 Q8N2N9 ANKRD36B PTHR24147:SF50 ANKYRIN REPEAT DOMAIN 36-RELATED ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 36A-RELATED HUMAN|HGNC=19952|UniProtKB=A0PG75 A0PG75 PLSCR5 PTHR23248:SF25 PHOSPHOLIPID SCRAMBLASE-RELATED PHOSPHOLIPID SCRAMBLASE FAMILY MEMBER 5 intramembrane lipid carrier activity#GO:0140303;phospholipid scramblase activity#GO:0017128;transporter activity#GO:0005215;lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104 cellular component organization#GO:0016043;organophosphate ester transport#GO:0015748;plasma membrane phospholipid scrambling#GO:0017121;lipid translocation#GO:0034204;lipid localization#GO:0010876;localization#GO:0051179;plasma membrane organization#GO:0007009;regulation of biological quality#GO:0065008;macromolecule localization#GO:0033036;cellular process#GO:0009987;lipid transport#GO:0006869;biological regulation#GO:0065007;membrane organization#GO:0061024;endomembrane system organization#GO:0010256;phospholipid transport#GO:0015914;phospholipid translocation#GO:0045332;transport#GO:0006810;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;regulation of membrane lipid distribution#GO:0097035 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227 HUMAN|HGNC=18171|UniProtKB=Q9BZW8 Q9BZW8 CD244 PTHR12080:SF56 SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE NATURAL KILLER CELL RECEPTOR 2B4 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 immune system process#GO:0002376;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;immune response#GO:0006955;signal transduction#GO:0007165;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=6408|UniProtKB=Q9Y5Q3 Q9Y5Q3 MAFB PTHR10129:SF10 TRANSCRIPTION FACTOR MAF TRANSCRIPTION FACTOR MAFB transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of cell differentiation#GO:0045595;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of cell development#GO:0060284;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of myeloid cell differentiation#GO:0045637;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of hemopoiesis#GO:1903706;regulation of multicellular organismal development#GO:2000026;regulation of biological process#GO:0050789;regulation of developmental process#GO:0050793;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 basic leucine zipper transcription factor#PC00056;DNA-binding transcription factor#PC00218 HUMAN|HGNC=25135|UniProtKB=Q6UWE0 Q6UWE0 LRSAM1 PTHR16083:SF39 LEUCINE RICH REPEAT CONTAINING PROTEIN E3 UBIQUITIN-PROTEIN LIGASE LRSAM1 scaffold/adaptor protein#PC00226 HUMAN|HGNC=23505|UniProtKB=Q14692 Q14692 BMS1 PTHR12858:SF2 RIBOSOME BIOGENESIS PROTEIN RIBOSOME BIOGENESIS PROTEIN BMS1 HOMOLOG RNA binding#GO:0003723;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;nucleic acid binding#GO:0003676;GTPase activity#GO:0003924;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462 nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;ribosomal small subunit biogenesis#GO:0042274;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000479;cellular component biogenesis#GO:0044085;maturation of SSU-rRNA#GO:0030490;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;gene expression#GO:0010467 intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;small-subunit processome#GO:0032040;organelle lumen#GO:0043233;90S preribosome#GO:0030686;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;nucleolus#GO:0005730;preribosome#GO:0030684 HUMAN|HGNC=28511|UniProtKB=Q8NHS1 Q8NHS1 CLDND2 PTHR10671:SF30 EPITHELIAL MEMBRANE PROTEIN-RELATED CLAUDIN DOMAIN-CONTAINING PROTEIN 2 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 cytoskeletal protein#PC00085 HUMAN|HGNC=19007|UniProtKB=Q8NE63 Q8NE63 HIPK4 PTHR24058:SF46 DUAL SPECIFICITY PROTEIN KINASE HOMEODOMAIN-INTERACTING PROTEIN KINASE 4 protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein tyrosine kinase activity#GO:0004713;catalytic activity#GO:0003824;transferase activity#GO:0016740 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 protein modifying enzyme#PC00260 HUMAN|HGNC=22205|UniProtKB=Q2PZI1 Q2PZI1 DPY19L1 PTHR31488:SF5 DPY-19-LIKE 1, LIKE (H. SAPIENS) PROTEIN C-MANNOSYL-TRANSFERASE DPY19L1 glycosyltransferase activity#GO:0016757;mannosyltransferase activity#GO:0000030;catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758 membrane#GO:0016020;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=28306|UniProtKB=Q8N945 Q8N945 PRELID2 PTHR11158:SF20 MSF1/PX19 RELATED PRELI DOMAIN-CONTAINING PROTEIN 2 lipid transfer activity#GO:0120013;phospholipid transfer activity#GO:0120014;transporter activity#GO:0005215;lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104 organophosphate ester transport#GO:0015748;lipid transport#GO:0006869;phospholipid transport#GO:0015914;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;localization#GO:0051179;lipid localization#GO:0010876;transport#GO:0006810 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;mitochondrial intermembrane space#GO:0005758;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrial envelope#GO:0005740;mitochondrion#GO:0005739;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;organelle envelope#GO:0031967;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 transfer/carrier protein#PC00219 HUMAN|HGNC=11653|UniProtKB=P20062 P20062 TCN2 PTHR10559:SF14 TRANSCOBALAMIN-1/GASTRIC INTRINSIC FACTOR TRANSCOBALAMIN-2 tetrapyrrole binding#GO:0046906;heterocyclic compound binding#GO:1901363;small molecule binding#GO:0036094;binding#GO:0005488 localization#GO:0051179;establishment of localization#GO:0051234;vitamin transport#GO:0051180;nitrogen compound transport#GO:0071705;transport#GO:0006810 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=25429|UniProtKB=Q8N3G9 Q8N3G9 TMEM130 PTHR11861:SF10 MELANOCYTE PROTEIN PMEL 17-RELATED TRANSMEMBRANE PROTEIN 130 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 membrane-bound signaling molecule#PC00152 HUMAN|HGNC=19044|UniProtKB=A0AVI2 A0AVI2 FER1L5 PTHR12546:SF34 FER-1-LIKE FER-1-LIKE PROTEIN 5 developmental process#GO:0032502;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;cellular process#GO:0009987;membrane fusion#GO:0061025;response to wounding#GO:0009611;response to stress#GO:0006950;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;animal gross anatomical part developmental process#GO:0160108;wound healing#GO:0042060;plasma membrane organization#GO:0007009;anatomical structure development#GO:0048856;muscle cell differentiation#GO:0042692;muscle cell development#GO:0055001;cellular component organization#GO:0016043;cell development#GO:0048468;cell differentiation#GO:0030154;response to stimulus#GO:0050896;muscle structure development#GO:0061061 membrane trafficking regulatory protein#PC00151 HUMAN|Ensembl=ENSG00000292244.1|UniProtKB=A0AAG2UWQ9 A0AAG2UWQ9 NKRF PTHR16148:SF15 NF-KAPPA-B-REPRESSING FACTOR-RELATED NF-KAPPA-B-REPRESSING FACTOR DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;molecular function regulator activity#GO:0098772;ATPase activator activity#GO:0001671;DNA-binding transcription activator activity#GO:0001216;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;molecular function activator activity#GO:0140677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=986|UniProtKB=P12694 P12694 BCKDHA PTHR43380:SF1 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;small molecule catabolic process#GO:0044282;amino acid metabolic process#GO:0006520;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436 oxidoreductase complex#GO:1990204;transferase complex#GO:1990234;catalytic complex#GO:1902494;protein-containing complex#GO:0032991 dehydrogenase#PC00092;oxidoreductase#PC00176 HUMAN|HGNC=29531|UniProtKB=Q6PKG0 Q6PKG0 LARP1 PTHR22792:SF51 LUPUS LA PROTEIN-RELATED LA-RELATED PROTEIN 1 nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 RNA metabolism protein#PC00031 HUMAN|HGNC=7121|UniProtKB=Q9NXB0 Q9NXB0 MKS1 PTHR12968:SF4 B9 DOMAIN-CONTAINING TECTONIC-LIKE COMPLEX MEMBER MKS1 organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031;cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782;cellular component organization#GO:0016043;cilium assembly#GO:0060271;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component assembly#GO:0022607;cell projection organization#GO:0030030;plasma membrane bounded cell projection organization#GO:0120036 membrane-bounded organelle#GO:0043227;ciliary transition zone#GO:0035869;cilium#GO:0005929;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995 structural protein#PC00211 HUMAN|HGNC=572|UniProtKB=Q9Y6B7 Q9Y6B7 AP4B1 PTHR11134:SF4 ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER AP-4 COMPLEX SUBUNIT BETA-1 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;Golgi apparatus#GO:0005794;AP-type membrane coat adaptor complex#GO:0030119;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;membrane coat#GO:0030117;coated membrane#GO:0048475 membrane traffic protein#PC00150 HUMAN|HGNC=15676|UniProtKB=Q9BWG4 Q9BWG4 SSBP4 PTHR12610:SF30 SINGLE STRANDED DNA BINDING PROTEIN SINGLE-STRANDED DNA-BINDING PROTEIN 4 DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of RNA metabolic process#GO:0051252 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 DNA metabolism protein#PC00009 HUMAN|HGNC=34498|UniProtKB=B1ATL7 B1ATL7 PRR32 PTHR37343:SF1 PROLINE-RICH PROTEIN 32 PROLINE-RICH PROTEIN 32 HUMAN|HGNC=20881|UniProtKB=Q5T4I8 Q5T4I8 C6orf52 PTHR37457:SF1 TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED SIMILAR TO HUMAN CHROMOSOME 6 OPEN READING FRAME 52 RNA binding#GO:0003723;tRNA binding#GO:0000049;binding#GO:0005488;nucleic acid binding#GO:0003676 post-transcriptional regulation of gene expression#GO:0010608;translational elongation#GO:0006414;metabolic process#GO:0008152;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;biosynthetic process#GO:0009058;biological regulation#GO:0065007;gene expression#GO:0010467;translation#GO:0006412;protein metabolic process#GO:0019538;regulation of biological process#GO:0050789;primary metabolic process#GO:0044238;protein biosynthetic process#GO:0160307;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=25446|UniProtKB=Q69YI7 Q69YI7 NAIF1 PTHR23098:SF7 AGAP001331-PA-RELATED NUCLEAR APOPTOSIS-INDUCING FACTOR 1 HUMAN|HGNC=9885|UniProtKB=P29374 P29374 ARID4A PTHR13964:SF26 RBP-RELATED AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 4A double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 transcription cofactor#PC00217 HUMAN|HGNC=17827|UniProtKB=O15466 O15466 ST8SIA5 PTHR11987:SF4 ALPHA-2,8-SIALYLTRANSFERASE ALPHA-2,8-SIALYLTRANSFERASE 8E catalytic activity#GO:0003824;transferase activity#GO:0016740;sialyltransferase activity#GO:0008373;glycosyltransferase activity#GO:0016757 biosynthetic process#GO:0009058;carbohydrate metabolic process#GO:0005975;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;protein N-linked glycosylation#GO:0006487;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;oligosaccharide metabolic process#GO:0009311;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152 metabolite interconversion enzyme#PC00262;transferase#PC00220 HUMAN|HGNC=6863|UniProtKB=Q92918 Q92918 MAP4K1 PTHR48012:SF15 STERILE20-LIKE KINASE, ISOFORM B-RELATED MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 1 kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Apoptosis signaling pathway#P00006>GCK#P00268;Apoptosis signaling pathway#P00006>GCKR#P00311;Gonadotropin-releasing hormone receptor pathway#P06664>MAP4Ks#P06861 HUMAN|HGNC=10580|UniProtKB=Q9UN30 Q9UN30 SCML1 PTHR12247:SF128 POLYCOMB GROUP PROTEIN SEX COMB ON MIDLEG-LIKE PROTEIN 1 chromatin binding#GO:0003682;histone binding#GO:0042393;binding#GO:0005488;protein binding#GO:0005515 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=4575|UniProtKB=Q9ULK0 Q9ULK0 GRID1 PTHR18966:SF108 IONOTROPIC GLUTAMATE RECEPTOR GLUTAMATE RECEPTOR IONOTROPIC, DELTA-1 carboxylic acid transmembrane transporter activity#GO:0046943;ligand-gated monoatomic ion channel activity#GO:0015276;channel activity#GO:0015267;molecular transducer activity#GO:0060089;transmembrane transporter activity#GO:0022857;ligand-gated channel activity#GO:0022834;glutamate receptor activity#GO:0008066;passive transmembrane transporter activity#GO:0022803;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;dicarboxylic acid transmembrane transporter activity#GO:0005310;gated channel activity#GO:0022836;transmembrane signaling receptor activity#GO:0004888;transporter activity#GO:0005215;amino acid transmembrane transporter activity#GO:0015171;neurotransmitter receptor activity#GO:0030594;signaling receptor activity#GO:0038023;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;extracellular ligand-gated monoatomic ion channel activity#GO:0005230 synaptic signaling#GO:0099536;cellular process#GO:0009987;regulation of trans-synaptic signaling#GO:0099177;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;synaptic transmission, glutamatergic#GO:0035249;trans-synaptic signaling#GO:0099537;regulation of signaling#GO:0023051;cell communication#GO:0007154;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;regulation of cell communication#GO:0010646;signaling#GO:0023052;modulation of chemical synaptic transmission#GO:0050804 signaling receptor complex#GO:0043235;membrane#GO:0016020;cell periphery#GO:0071944;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;monoatomic ion channel complex#GO:0034702;neuron to neuron synapse#GO:0098984;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;dendrite#GO:0030425;dendritic tree#GO:0097447;postsynaptic density#GO:0014069;transmembrane transporter complex#GO:1902495;postsynaptic density membrane#GO:0098839;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;asymmetric synapse#GO:0032279;plasma membrane bounded cell projection#GO:0120025;synaptic membrane#GO:0097060;cell junction#GO:0030054;transporter complex#GO:1990351;neuron projection#GO:0043005;protein-containing complex#GO:0032991;postsynaptic specialization membrane#GO:0099634;postsynaptic membrane#GO:0045211;postsynapse#GO:0098794;dendritic spine#GO:0043197;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;neuron spine#GO:0044309 transmembrane signal receptor#PC00197 HUMAN|HGNC=16904|UniProtKB=P54108 P54108 CRISP3 PTHR10334:SF577 CYSTEINE-RICH SECRETORY PROTEIN-RELATED CYSTEINE-RICH SECRETORY PROTEIN 3 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090 HUMAN|HGNC=26786|UniProtKB=Q8N8Y5 Q8N8Y5 ZFP41 PTHR24381:SF381 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 41 HOMOLOG double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=9789|UniProtKB=O14966 O14966 RAB29 PTHR24073:SF315 DRAB5-RELATED RAS-RELATED PROTEIN RAB-29 ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462 cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;protein transport#GO:0015031;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184 organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;Golgi apparatus subcompartment#GO:0098791;mitochondrion#GO:0005739 G-protein#PC00020;small GTPase#PC00208 HUMAN|HGNC=32310|UniProtKB=Q8IXT5 Q8IXT5 RBM12B PTHR13976:SF28 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED RNA-BINDING PROTEIN 12B RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 protein-containing complex#GO:0032991;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229 RNA splicing factor#PC00148;RNA metabolism protein#PC00031;RNA processing factor#PC00147 HUMAN|HGNC=35241|UniProtKB=A6NC57 A6NC57 ANKRD62 PTHR24147:SF29 ANKYRIN REPEAT DOMAIN 36-RELATED ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 62 HUMAN|HGNC=32671|UniProtKB=Q6ZMU5 Q6ZMU5 TRIM72 PTHR24103:SF11 E3 UBIQUITIN-PROTEIN LIGASE TRIM TRIPARTITE MOTIF-CONTAINING PROTEIN 72 ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740 modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to stimulus#GO:0050896;catabolic process#GO:0009056;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;immune system process#GO:0002376;protein metabolic process#GO:0019538;defense response to symbiont#GO:0140546;immune response#GO:0006955;cellular process#GO:0009987;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;proteasomal protein catabolic process#GO:0010498;response to other organism#GO:0051707;defense response to other organism#GO:0098542;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;response to external stimulus#GO:0009605;ubiquitin-dependent protein catabolic process#GO:0006511;defense response#GO:0006952;macromolecule metabolic process#GO:0043170;innate immune response#GO:0045087 cell periphery#GO:0071944;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;sarcolemma#GO:0042383 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=26523|UniProtKB=Q5W0A0 Q5W0A0 ERICH6B PTHR23093:SF17 SIMILAR TO CHROMOSOME 3 OPEN READING FRAME 20 GLUTAMATE-RICH PROTEIN 6B HUMAN|HGNC=17256|UniProtKB=Q9P1U1 Q9P1U1 ACTR3B PTHR11937:SF514 ACTIN ACTIN-RELATED PROTEIN 3B structural molecule activity#GO:0005198;cytoskeletal protein binding#GO:0008092;protein-containing complex binding#GO:0044877;protein binding#GO:0005515;actin binding#GO:0003779;actin filament binding#GO:0051015;binding#GO:0005488;structural constituent of cytoskeleton#GO:0005200 cortical cytoskeleton organization#GO:0030865;actin filament-based process#GO:0030029;cellular component organization or biogenesis#GO:0071840;cortical actin cytoskeleton organization#GO:0030866;actin filament organization#GO:0007015;supramolecular fiber organization#GO:0097435;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;Arp2/3 complex-mediated actin nucleation#GO:0034314;actin cytoskeleton organization#GO:0030036;actin nucleation#GO:0045010;cytoskeleton organization#GO:0007010 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;Arp2/3 protein complex#GO:0005885;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;actin cytoskeleton#GO:0015629;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232 actin and actin related protein#PC00039 HUMAN|HGNC=24713|UniProtKB=Q2TAL8 Q2TAL8 QRICH1 PTHR45736:SF8 ZINC FINGER MYM-TYPE PROTEIN TRANSCRIPTIONAL REGULATOR QRICH1 zinc finger transcription factor#PC00244;DNA-binding transcription factor#PC00218 HUMAN|HGNC=1301|UniProtKB=P57076 P57076 CFAP298 PTHR13238:SF0 PROTEIN C21ORF59 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 298 HUMAN|HGNC=28207|UniProtKB=Q86VX9 Q86VX9 MON1A PTHR13027:SF14 SAND PROTEIN-RELATED VACUOLAR FUSION PROTEIN MON1 HOMOLOG A molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;guanyl-nucleotide exchange factor activity#GO:0005085 transport#GO:0006810;establishment of protein localization to extracellular region#GO:0035592;protein transport#GO:0015031;intracellular protein localization#GO:0008104;secretion by cell#GO:0032940;establishment of localization#GO:0051234;secretion#GO:0046903;localization#GO:0051179;protein secretion#GO:0009306;protein localization to extracellular region#GO:0071692;cellular process#GO:0009987;establishment of protein localization#GO:0045184;macromolecule localization#GO:0033036;export from cell#GO:0140352 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;late endosome#GO:0005770;guanyl-nucleotide exchange factor complex#GO:0032045;endomembrane system#GO:0012505;intracellular protein-containing complex#GO:0140535;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=4685|UniProtKB=Q02108 Q02108 GUCY1A1 PTHR45655:SF4 GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2 GUANYLATE CYCLASE SOLUBLE SUBUNIT ALPHA-1 catalytic activity#GO:0003824;cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;lyase activity#GO:0016829;guanylate cyclase activity#GO:0004383 nucleoside phosphate metabolic process#GO:0006753;primary metabolic process#GO:0044238;response to oxygen levels#GO:0070482;organophosphate biosynthetic process#GO:0090407;cGMP biosynthetic process#GO:0006182;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;cGMP metabolic process#GO:0046068;carbohydrate derivative metabolic process#GO:1901135;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;nucleoside phosphate biosynthetic process#GO:1901293;cyclic nucleotide metabolic process#GO:0009187;response to stimulus#GO:0050896;small molecule metabolic process#GO:0044281;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;response to abiotic stimulus#GO:0009628;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;cyclic nucleotide biosynthetic process#GO:0009190;ribonucleotide metabolic process#GO:0009259;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;ribose phosphate biosynthetic process#GO:0046390;nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative biosynthetic process#GO:1901137;cyclic purine nucleotide metabolic process#GO:0052652;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;cytosol#GO:0005829 cyclase#PC00079;guanylate cyclase#PC00114 Endothelin signaling pathway#P00019>Guanylate cyclase#P00581 HUMAN|HGNC=11765|UniProtKB=P01135 P01135 TGFA PTHR10740:SF1 TRANSFORMING GROWTH FACTOR ALPHA PROTRANSFORMING GROWTH FACTOR ALPHA molecular function activator activity#GO:0140677;protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;growth factor receptor binding#GO:0070851;receptor ligand activity#GO:0048018;growth factor activity#GO:0008083;signaling receptor regulator activity#GO:0030545 positive regulation of mitotic nuclear division#GO:0045840;cell surface receptor signaling pathway#GO:0007166;regulation of mitotic nuclear division#GO:0007088;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of cellular process#GO:0048522;ERBB signaling pathway#GO:0038127;regulation of mitotic cell cycle#GO:0007346;cellular process#GO:0009987;biological regulation#GO:0065007;regulation of cell cycle process#GO:0010564;positive regulation of cell cycle#GO:0045787;regulation of nuclear division#GO:0051783;epidermal growth factor receptor signaling pathway#GO:0007173;positive regulation of cellular component organization#GO:0051130;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of cell population proliferation#GO:0042127;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of organelle organization#GO:0010638;regulation of biological process#GO:0050789;positive regulation of cell cycle process#GO:0090068;cellular response to stimulus#GO:0051716;regulation of organelle organization#GO:0033043;positive regulation of cell population proliferation#GO:0008284;regulation of cell cycle#GO:0051726;signaling#GO:0023052;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 growth factor#PC00112 EGF receptor signaling pathway#P00018>EGF#P00549 HUMAN|HGNC=27258|UniProtKB=Q86VR2 Q86VR2 RETREG3 PTHR28659:SF1 RETICULON-LIKE PROTEIN RETICULOPHAGY REGULATOR 3 HUMAN|HGNC=18593|UniProtKB=Q8NG66 Q8NG66 NEK11 PTHR43671:SF111 SERINE/THREONINE-PROTEIN KINASE NEK SERINE_THREONINE-PROTEIN KINASE NEK11 catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674 negative regulation of cell cycle#GO:0045786;cellular process#GO:0009987;signal transduction#GO:0007165;response to stress#GO:0006950;regulation of cell cycle process#GO:0010564;cell cycle checkpoint signaling#GO:0000075;cellular response to stress#GO:0033554;negative regulation of mitotic cell cycle#GO:0045930;mitotic intra-S DNA damage checkpoint signaling#GO:0031573;regulation of mitotic cell cycle phase transition#GO:1901990;cell cycle process#GO:0022402;signal transduction in response to DNA damage#GO:0042770;regulation of biological process#GO:0050789;negative regulation of cell cycle phase transition#GO:1901988;negative regulation of biological process#GO:0048519;signaling#GO:0023052;regulation of cell cycle#GO:0051726;response to stimulus#GO:0050896;negative regulation of cell cycle process#GO:0010948;DNA damage response#GO:0006974;negative regulation of cellular process#GO:0048523;mitotic cell cycle process#GO:1903047;mitotic DNA integrity checkpoint signaling#GO:0044774;regulation of mitotic cell cycle#GO:0007346;DNA integrity checkpoint signaling#GO:0031570;biological regulation#GO:0065007;DNA damage checkpoint signaling#GO:0000077;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;mitotic DNA damage checkpoint signaling#GO:0044773;cellular response to stimulus#GO:0051716;cell cycle#GO:0007049;regulation of cell cycle phase transition#GO:1901987;mitotic cell cycle checkpoint signaling#GO:0007093;regulation of cellular process#GO:0050794;mitotic cell cycle#GO:0000278 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=11445|UniProtKB=Q15833 Q15833 STXBP2 PTHR11679:SF27 VESICLE PROTEIN SORTING-ASSOCIATED SYNTAXIN-BINDING PROTEIN 2 syntaxin binding#GO:0019905;protein binding#GO:0005515;binding#GO:0005488;SNARE binding#GO:0000149 anterograde trans-synaptic signaling#GO:0098916;chemical synaptic transmission#GO:0007268;signal release from synapse#GO:0099643;secretion#GO:0046903;cell communication#GO:0007154;localization#GO:0051179;organelle localization#GO:0051640;trans-synaptic signaling#GO:0099537;signal release#GO:0023061;neurotransmitter secretion#GO:0007269;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;macromolecule localization#GO:0033036;vesicle localization#GO:0051648;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;calcium-ion regulated exocytosis#GO:0017156;intracellular transport#GO:0046907;transport#GO:0006810;synaptic vesicle cycle#GO:0099504;establishment of organelle localization#GO:0051656;export from cell#GO:0140352;signaling#GO:0023052;regulation of biological process#GO:0050789;cellular localization#GO:0051641;protein transport#GO:0015031;secretion by cell#GO:0032940;vesicle-mediated transport#GO:0016192;neurotransmitter transport#GO:0006836;establishment of vesicle localization#GO:0051650;synaptic signaling#GO:0099536;cellular process#GO:0009987;synaptic vesicle exocytosis#GO:0016079;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;vesicle-mediated transport in synapse#GO:0099003;exocytosis#GO:0006887;regulated exocytosis#GO:0045055;intracellular protein transport#GO:0006886 endomembrane system#GO:0012505;plasma membrane#GO:0005886;cytoplasm#GO:0005737;secretory vesicle#GO:0099503;membrane#GO:0016020;cell periphery#GO:0071944;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982 membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=179|UniProtKB=P07311 P07311 ACYP1 PTHR10029:SF3 ACYLPHOSPHATASE ACYLPHOSPHATASE-1 hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817 metabolite interconversion enzyme#PC00262;phosphatase#PC00181 HUMAN|HGNC=19098|UniProtKB=Q6ZRY4 Q6ZRY4 RBPMS2 PTHR10501:SF87 U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B RNA-BINDING PROTEIN WITH MULTIPLE SPLICING 2 mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 regulation of cellular process#GO:0050794;regulation of developmental process#GO:0050793;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;negative regulation of biological process#GO:0048519;regulation of cell differentiation#GO:0045595;regulation of biological process#GO:0050789 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 RNA processing factor#PC00147;RNA metabolism protein#PC00031;RNA splicing factor#PC00148 HUMAN|HGNC=19178|UniProtKB=Q96FZ5 Q96FZ5 CMTM7 PTHR22776:SF89 MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN CKLF-LIKE MARVEL TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 7 regulation of biological process#GO:0050789;immune response-regulating signaling pathway#GO:0002764;toll-like receptor signaling pathway#GO:0002224;signaling#GO:0023052;response to stimulus#GO:0050896;immune system process#GO:0002376;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;cellular process#GO:0009987;positive regulation of immune system process#GO:0002684;lymphocyte activation#GO:0046649;regulation of response to external stimulus#GO:0032101;B cell activation#GO:0042113;immune response-activating signaling pathway#GO:0002757;positive regulation of response to external stimulus#GO:0032103;cellular response to stimulus#GO:0051716;leukocyte activation#GO:0045321;innate immune response-activating signaling pathway#GO:0002758;regulation of response to biotic stimulus#GO:0002831;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of immune response#GO:0050776;regulation of defense response#GO:0031347;cell activation#GO:0001775;cell communication#GO:0007154;immune response#GO:0006955;positive regulation of innate immune response#GO:0045089;activation of innate immune response#GO:0002218;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;multicellular organismal process#GO:0032501;positive regulation of defense response#GO:0031349;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;regulation of response to stress#GO:0080134;positive regulation of response to biotic stimulus#GO:0002833;pattern recognition receptor signaling pathway#GO:0002221;regulation of innate immune response#GO:0045088 cellular anatomical structure#GO:0110165;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HUMAN|HGNC=19104|UniProtKB=O75161 O75161 NPHP4 PTHR31043:SF3 NEPHROCYSTIN-4 NEPHROCYSTIN-4 negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;regulation of canonical Wnt signaling pathway#GO:0060828;negative regulation of Wnt signaling pathway#GO:0030178;negative regulation of response to stimulus#GO:0048585;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;negative regulation of signaling#GO:0023057;negative regulation of canonical Wnt signaling pathway#GO:0090090;regulation of signaling#GO:0023051;localization#GO:0051179;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;protein localization to organelle#GO:0033365;regulation of cellular process#GO:0050794;protein localization to cilium#GO:0061512;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111 membrane-bounded organelle#GO:0043227;non-motile cilium#GO:0097730;intracellular anatomical structure#GO:0005622;ciliary transition zone#GO:0035869;cilium#GO:0005929;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;membraneless organelle#GO:0043228;microtubule organizing center#GO:0005815;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;ciliary base#GO:0097546 HUMAN|HGNC=15505|UniProtKB=Q96N66 Q96N66 MBOAT7 PTHR13906:SF16 PORCUPINE MEMBRANE-BOUND ACYLGLYCEROPHOSPHATIDYLINOSITOL O-ACYLTRANSFERASE MBOAT7 catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 glycerophospholipid metabolic process#GO:0006650;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058;organophosphate metabolic process#GO:0019637;glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987;lipid modification#GO:0030258;metabolic process#GO:0008152;glycerophospholipid biosynthetic process#GO:0046474;phosphatidylinositol metabolic process#GO:0046488;lipid metabolic process#GO:0006629;glycerolipid metabolic process#GO:0046486;phospholipid biosynthetic process#GO:0008654;phospholipid metabolic process#GO:0006644;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;organophosphate biosynthetic process#GO:0090407 organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondria-associated endoplasmic reticulum membrane contact site#GO:0044233;organelle membrane contact site#GO:0044232;membrane#GO:0016020 acetyltransferase#PC00038 HUMAN|HGNC=7422|UniProtKB=P00414 P00414 MT-CO3 PTHR11403:SF7 CYTOCHROME C OXIDASE SUBUNIT III CYTOCHROME C OXIDASE SUBUNIT 3 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;proton transmembrane transporter activity#GO:0015078;catalytic activity#GO:0003824;primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804;monoatomic ion transmembrane transporter activity#GO:0015075;oxidoreductase activity#GO:0016491;monoatomic cation transmembrane transporter activity#GO:0008324;electron transfer activity#GO:0009055 energy derivation by oxidation of organic compounds#GO:0015980;cellular respiration#GO:0045333;oxidative phosphorylation#GO:0006119;ATP synthesis coupled electron transport#GO:0042773;aerobic respiration#GO:0009060;mitochondrial electron transport, cytochrome c to oxygen#GO:0006123;aerobic electron transport chain#GO:0019646;metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091;electron transport chain#GO:0022900;cellular process#GO:0009987;respiratory electron transport chain#GO:0022904;mitochondrial ATP synthesis coupled electron transport#GO:0042775 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739 oxidoreductase#PC00176;oxidase#PC00175 HUMAN|HGNC=2257|UniProtKB=O00230 O00230 CORT PTHR10558:SF1 SOMATOSTATIN CORTISTATIN signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515;hormone activity#GO:0005179;molecular function activator activity#GO:0140677;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;G protein-coupled receptor binding#GO:0001664;neuropeptide hormone activity#GO:0005184;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772 response to chemical#GO:0042221;biological regulation#GO:0065007;response to hormone#GO:0009725;signal transduction#GO:0007165;cellular process#GO:0009987;cell communication#GO:0007154;hormone-mediated signaling pathway#GO:0009755;G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;regulation of cellular process#GO:0050794;cellular response to hormone stimulus#GO:0032870;signaling#GO:0023052;response to endogenous stimulus#GO:0009719;neuropeptide signaling pathway#GO:0007218;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207;peptide hormone#PC00179 HUMAN|HGNC=20190|UniProtKB=Q6P0N0 Q6P0N0 MIS18BP1 PTHR16124:SF3 MIS18-BINDING PROTEIN 1 MIS18-BINDING PROTEIN 1 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687;chromosome, centromeric region#GO:0000775;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694 HUMAN|HGNC=2883|UniProtKB=P49895 P49895 DIO1 PTHR11781:SF22 IODOTHYRONINE DEIODINASE TYPE I IODOTHYRONINE DEIODINASE metabolite interconversion enzyme#PC00262 HUMAN|HGNC=25276|UniProtKB=Q9H0K6 Q9H0K6 PUS7L PTHR13326:SF21 TRNA PSEUDOURIDINE SYNTHASE D PSEUDOURIDYLATE SYNTHASE PUS7L intramolecular transferase activity#GO:0016866;catalytic activity#GO:0003824;isomerase activity#GO:0016853 nucleobase-containing compound metabolic process#GO:0006139;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular process#GO:0009987;pseudouridine synthesis#GO:0001522;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;RNA modification#GO:0009451 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=897|UniProtKB=P30518 P30518 AVPR2 PTHR24241:SF20 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR VASOPRESSIN V2 RECEPTOR G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888 regulation of system process#GO:0044057;regulation of anatomical structure size#GO:0090066;system process#GO:0003008;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;response to hormone#GO:0009725;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;blood circulation#GO:0008015;response to chemical#GO:0042221;circulatory system process#GO:0003013;G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887;positive regulation of cytosolic calcium ion concentration#GO:0007204;regulation of biological quality#GO:0065008;cell communication#GO:0007154;positive regulation of multicellular organismal process#GO:0051240;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;signaling#GO:0023052;regulation of cellular process#GO:0050794;cellular response to hormone stimulus#GO:0032870;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=1461|UniProtKB=Q13554 Q13554 CAMK2B PTHR24347:SF403 SERINE/THREONINE-PROTEIN KINASE CALCIUM_CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT BETA transferase activity#GO:0016740;catalytic activity#GO:0003824;calmodulin binding#GO:0005516;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;binding#GO:0005488;protein serine/threonine kinase activity#GO:0004674;calcium/calmodulin-dependent protein kinase activity#GO:0004683;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein binding#GO:0005515;protein kinase activity#GO:0004672 regulation of neuronal synaptic plasticity#GO:0048168;regulation of protein localization#GO:0032880;regulation of localization#GO:0032879;regulation of biological quality#GO:0065008;regulation of synaptic plasticity#GO:0048167;regulation of signaling#GO:0023051;regulation of cellular process#GO:0050794;regulation of trans-synaptic signaling#GO:0099177;biological regulation#GO:0065007;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;regulation of protein localization to membrane#GO:1905475;regulation of biological process#GO:0050789 cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;synapse#GO:0045202;cellular anatomical structure#GO:0110165;neuron to neuron synapse#GO:0098984;asymmetric synapse#GO:0032279;organelle#GO:0043226;postsynaptic specialization#GO:0099572;neuron projection#GO:0043005;postsynapse#GO:0098794;intracellular anatomical structure#GO:0005622;cell junction#GO:0030054;postsynaptic density#GO:0014069;axon#GO:0030424 non-receptor serine/threonine protein kinase#PC00167 Ionotropic glutamate receptor pathway#P00037>CaMKII#P01023;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CaMK#P00847;Gonadotropin-releasing hormone receptor pathway#P06664>Ca/CaMK II#P06735 HUMAN|HGNC=26754|UniProtKB=A2RUC4 A2RUC4 TYW5 PTHR12461:SF104 HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 5 catalytic activity, acting on a tRNA#GO:0140101;tRNA binding#GO:0000049;RNA binding#GO:0003723;dioxygenase activity#GO:0051213;binding#GO:0005488;nucleic acid binding#GO:0003676;catalytic activity, acting on RNA#GO:0140098;oxidoreductase activity#GO:0016491;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640 RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187;tRNA modification#GO:0006400;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;carbohydrate derivative biosynthetic process#GO:1901137;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135 protein modifying enzyme#PC00260 HUMAN|HGNC=10935|UniProtKB=Q05940 Q05940 SLC18A2 PTHR23506:SF30 GH10249P SYNAPTIC VESICULAR AMINE TRANSPORTER solute:sodium symporter activity#GO:0015370;sodium ion transmembrane transporter activity#GO:0015081;active transmembrane transporter activity#GO:0022804;solute:monoatomic cation symporter activity#GO:0015294;monoamine transmembrane transporter activity#GO:0008504;transmembrane transporter activity#GO:0022857;chloride transmembrane transporter activity#GO:0015108;monoatomic cation transmembrane transporter activity#GO:0008324;symporter activity#GO:0015293;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic anion transmembrane transporter activity#GO:0008509;secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;antiporter activity#GO:0015297;proton transmembrane transporter activity#GO:0015078 neurotransmitter transport#GO:0006836;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;nitrogen compound transport#GO:0071705;cellular localization#GO:0051641;establishment of localization#GO:0051234;vesicle-mediated transport in synapse#GO:0099003;localization#GO:0051179;synaptic vesicle cycle#GO:0099504;transport#GO:0006810 organelle membrane#GO:0031090;axon terminus#GO:0043679;transport vesicle#GO:0030133;transport vesicle membrane#GO:0030658;endomembrane system#GO:0012505;vesicle membrane#GO:0012506;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;axon#GO:0030424;neuron projection terminus#GO:0044306;terminal bouton#GO:0043195;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;distal axon#GO:0150034;synaptic vesicle membrane#GO:0030672;vesicle#GO:0031982;synaptic vesicle#GO:0008021;bounding membrane of organelle#GO:0098588;cell junction#GO:0030054;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;presynapse#GO:0098793;neuron projection#GO:0043005;secretory vesicle#GO:0099503;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;cell projection#GO:0042995;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;intracellular vesicle#GO:0097708 secondary carrier transporter#PC00258;transporter#PC00227 5HT4 type receptor mediated signaling pathway#P04376>5HT vesicular transporter#P04432;5HT1 type receptor mediated signaling pathway#P04373>5HT vesicular transporter#P04410;CCKR signaling map#P06959>VMAT2#G07295;Dopamine receptor mediated signaling pathway#P05912>VAT2#P05960;Nicotine pharmacodynamics pathway#P06587>SLC18A2#P06604;5HT2 type receptor mediated signaling pathway#P04374>5HT vesicular transporter#P04418;5HT3 type receptor mediated signaling pathway#P04375>5HT vesicular transporter#P04424;CCKR signaling map#P06959>VMAT2#P07137;CCKR signaling map#P06959>VMAT2#G07002;Adrenaline and noradrenaline biosynthesis#P00001>VAT2#P00070;Adrenaline and noradrenaline biosynthesis#P00001>VAT1#P00071 HUMAN|HGNC=11723|UniProtKB=P55061 P55061 TMBIM6 PTHR23291:SF133 BAX INHIBITOR-RELATED BAX INHIBITOR 1 enzyme inhibitor activity#GO:0004857;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;calcium channel activity#GO:0005262;passive transmembrane transporter activity#GO:0022803;metal ion transmembrane transporter activity#GO:0046873;molecular function regulator activity#GO:0098772;monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;calcium ion transmembrane transporter activity#GO:0015085;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234 regulation of apoptotic process#GO:0042981;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of response to stimulus#GO:0048585;negative regulation of apoptotic process#GO:0043066;cellular process#GO:0009987;negative regulation of programmed cell death#GO:0043069;response to stress#GO:0006950;negative regulation of cell communication#GO:0010648;response to unfolded protein#GO:0006986;regulation of apoptotic signaling pathway#GO:2001233;cellular response to topologically incorrect protein#GO:0035967;regulation of signaling#GO:0023051;negative regulation of apoptotic signaling pathway#GO:2001234;cellular response to stress#GO:0033554;cellular response to unfolded protein#GO:0034620;negative regulation of signaling#GO:0023057;regulation of cell communication#GO:0010646;response to topologically incorrect protein#GO:0035966;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067 endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 transporter#PC00227;ion channel#PC00133 Apoptosis signaling pathway#P00006>Bi1#P00277 HUMAN|HGNC=9604|UniProtKB=P23219 P23219 PTGS1 PTHR11903:SF6 PROSTAGLANDIN G/H SYNTHASE PROSTAGLANDIN G_H SYNTHASE 1 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen#GO:0016702;oxidoreductase activity#GO:0016491;dioxygenase activity#GO:0051213;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824 monocarboxylic acid biosynthetic process#GO:0072330;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;unsaturated fatty acid metabolic process#GO:0033559;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;lipid biosynthetic process#GO:0008610;icosanoid metabolic process#GO:0006690;fatty acid biosynthetic process#GO:0006633;icosanoid biosynthetic process#GO:0046456;biosynthetic process#GO:0009058;unsaturated fatty acid biosynthetic process#GO:0006636;long-chain fatty acid metabolic process#GO:0001676;cellular process#GO:0009987;oxoacid metabolic process#GO:0043436;olefinic compound metabolic process#GO:0120254;prostaglandin metabolic process#GO:0006693;small molecule metabolic process#GO:0044281;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;carboxylic acid biosynthetic process#GO:0046394;arachidonate metabolic process#GO:0019369 neuron projection#GO:0043005;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 oxygenase#PC00177;oxidoreductase#PC00176 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Cyclooxygenase#P00845 HUMAN|HGNC=29134|UniProtKB=A2RUS2 A2RUS2 DENND3 PTHR12296:SF32 DENN DOMAIN-CONTAINING PROTEIN 4 DENN DOMAIN-CONTAINING PROTEIN 3 guanyl-nucleotide exchange factor activity#GO:0005085;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function regulator activity#GO:0098772 regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular localization#GO:0051641;localization#GO:0051179;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;endosome to lysosome transport#GO:0008333;lysosomal transport#GO:0007041;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;regulation of small GTPase mediated signal transduction#GO:0051056;establishment of localization#GO:0051234;regulation of response to stimulus#GO:0048583;transport#GO:0006810;vacuolar transport#GO:0007034;intracellular transport#GO:0046907 intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227 protein-binding activity modulator#PC00095;guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=24355|UniProtKB=Q8NC01 Q8NC01 CLEC1A PTHR46490:SF1 C-TYPE LECTIN DOMAIN FAMILY 12 MEMBER A-RELATED C-TYPE LECTIN DOMAIN FAMILY 1 MEMBER A transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=12215|UniProtKB=A0A577 A0A577 TRBV4-1 PTHR23268:SF40 T-CELL RECEPTOR BETA CHAIN T CELL RECEPTOR BETA VARIABLE 4-1 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=9866|UniProtKB=P13631 P13631 RARG PTHR24082:SF116 NUCLEAR HORMONE RECEPTOR RETINOIC ACID RECEPTOR GAMMA transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023;transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;molecular transducer activity#GO:0060089;nuclear receptor activity#GO:0004879;DNA binding#GO:0003677;sequence-specific double-stranded DNA binding#GO:1990837 negative regulation of transcription by RNA polymerase II#GO:0000122;intracellular signal transduction#GO:0035556;regulation of RNA metabolic process#GO:0051252;cell communication#GO:0007154;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;cellular response to stimulus#GO:0051716;intracellular receptor signaling pathway#GO:0030522;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;nuclear receptor-mediated signaling pathway#GO:0141193;positive regulation of DNA-templated transcription#GO:0045893;cellular response to chemical stimulus#GO:0070887;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;negative regulation of DNA-templated transcription#GO:0045892;hormone-mediated signaling pathway#GO:0009755;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;cellular response to endogenous stimulus#GO:0071495;cell differentiation#GO:0030154;cellular response to hormone stimulus#GO:0032870;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;response to hormone#GO:0009725;positive regulation of macromolecule metabolic process#GO:0010604;response to chemical#GO:0042221 transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575 C4 zinc finger nuclear receptor#PC00169 HUMAN|HGNC=9319|UniProtKB=P60510 P60510 PPP4C PTHR45619:SF8 SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED SERINE_THREONINE-PROTEIN PHOSPHATASE 4 CATALYTIC SUBUNIT hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721;protein serine/threonine phosphatase activity#GO:0004722;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578 response to stress#GO:0006950;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA damage response#GO:0006974;DNA recombination#GO:0006310;macromolecule metabolic process#GO:0043170;double-strand break repair#GO:0006302;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;double-strand break repair via homologous recombination#GO:0000724;response to stimulus#GO:0050896;recombinational repair#GO:0000725;cellular response to stress#GO:0033554 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 protein phosphatase#PC00195;protein modifying enzyme#PC00260 FGF signaling pathway#P00021>PP2A#P00629;EGF receptor signaling pathway#P00018>PP2A#P00547 HUMAN|HGNC=847|UniProtKB=P18859 P18859 ATP5PF PTHR12441:SF10 ATP SYNTHASE COUPLING FACTOR 6, MITOCHONDRIAL ATP SYNTHASE PERIPHERAL STALK SUBUNIT F6, MITOCHONDRIAL proton-transporting ATP synthase complex#GO:0045259;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;respiratory chain complex#GO:0098803;membrane protein complex#GO:0098796;membrane#GO:0016020;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;catalytic complex#GO:1902494;cation channel complex#GO:0034703;proton-transporting two-sector ATPase complex#GO:0016469 ATP synthase#PC00002;primary active transporter#PC00068 HUMAN|HGNC=25178|UniProtKB=Q96CP2 Q96CP2 FLYWCH2 PTHR31665:SF0 FLYWCH FAMILY MEMBER 2-RELATED FLYWCH FAMILY MEMBER 2 HUMAN|HGNC=17004|UniProtKB=Q9H0M0 Q9H0M0 WWP1 PTHR11254:SF299 HECT DOMAIN UBIQUITIN-PROTEIN LIGASE NEDD4-LIKE E3 UBIQUITIN-PROTEIN LIGASE WWP1 ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824 ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Ubiquitin proteasome pathway#P00060>E3#P01490 HUMAN|HGNC=9552|UniProtKB=P62195 P62195 PSMC5 PTHR23073:SF12 26S PROTEASOME REGULATORY SUBUNIT 26S PROTEASOME REGULATORY SUBUNIT 8 macromolecular conformation isomerase activity#GO:0120543;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;polypeptide conformation or assembly isomerase activity#GO:0120544;isomerase activity#GO:0016853 ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238 intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;catalytic complex#GO:1902494;endopeptidase complex#GO:1905369;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;peptidase complex#GO:1905368;proteasome complex#GO:0000502 protease#PC00190 Ubiquitin proteasome pathway#P00060>26S proteasome#P01489 HUMAN|HGNC=19694|UniProtKB=Q6ZWJ1 Q6ZWJ1 STXBP4 PTHR19964:SF16 MULTIPLE PDZ DOMAIN PROTEIN SYNTAXIN-BINDING PROTEIN 4 SNARE binding#GO:0000149;binding#GO:0005488;protein binding#GO:0005515;syntaxin binding#GO:0019905 signaling#GO:0023052;cellular response to peptide hormone stimulus#GO:0071375;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cellular response to hormone stimulus#GO:0032870;regulation of biological process#GO:0050789;response to insulin#GO:0032868;cellular response to stimulus#GO:0051716;response to endogenous stimulus#GO:0009719;response to nitrogen compound#GO:1901698;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;insulin receptor signaling pathway#GO:0008286;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;response to oxygen-containing compound#GO:1901700;cellular response to chemical stimulus#GO:0070887;biological regulation#GO:0065007;response to peptide hormone#GO:0043434;response to chemical#GO:0042221;cellular response to nitrogen compound#GO:1901699;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;cellular process#GO:0009987;response to hormone#GO:0009725;cellular response to insulin stimulus#GO:0032869;cell surface receptor signaling pathway#GO:0007166 intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular vesicle#GO:0097708;vesicle#GO:0031982 scaffold/adaptor protein#PC00226 HUMAN|HGNC=18466|UniProtKB=O60930 O60930 RNASEH1 PTHR10642:SF35 RIBONUCLEASE H1 RIBONUCLEASE H1 nuclease activity#GO:0004518;hydrolase activity#GO:0016787;endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;RNA endonuclease activity#GO:0004521;catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 nucleobase-containing compound metabolic process#GO:0006139;nucleobase-containing compound catabolic process#GO:0034655;nucleic acid catabolic process#GO:0141188;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;DNA metabolic process#GO:0006259;catabolic process#GO:0009056;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;DNA replication#GO:0006260;DNA-templated DNA replication#GO:0006261;mitochondrial DNA metabolic process#GO:0032042;RNA metabolic process#GO:0016070;RNA catabolic process#GO:0006401 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031;endoribonuclease#PC00094 DNA replication#P00017>RNase H#P00538 HUMAN|HGNC=11027|UniProtKB=P02730 P02730 SLC4A1 PTHR11453:SF12 ANION EXCHANGE PROTEIN BAND 3 ANION TRANSPORT PROTEIN chloride transmembrane transporter activity#GO:0015108;antiporter activity#GO:0015297;bicarbonate transmembrane transporter activity#GO:0015106;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic anion transmembrane transporter activity#GO:0008509;secondary active transmembrane transporter activity#GO:0015291;monoatomic ion transmembrane transporter activity#GO:0015075;active transmembrane transporter activity#GO:0022804 monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;intracellular monoatomic cation homeostasis#GO:0030003;transport#GO:0006810;establishment of localization#GO:0051234;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;biological regulation#GO:0065007;regulation of pH#GO:0006885;regulation of intracellular pH#GO:0051453;localization#GO:0051179;transmembrane transport#GO:0055085;regulation of biological quality#GO:0065008;intracellular monoatomic ion homeostasis#GO:0006873;homeostatic process#GO:0042592 cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;plasma membrane#GO:0005886;membrane#GO:0016020;basal part of cell#GO:0045178;basolateral plasma membrane#GO:0016323;cell periphery#GO:0071944;basal plasma membrane#GO:0009925 secondary carrier transporter#PC00258 HUMAN|HGNC=18437|UniProtKB=Q8TDQ0 Q8TDQ0 HAVCR2 PTHR15498:SF73 T-CELL IMMUNOGLOBULIN AND MUCIN DOMAIN CONTAINING TIM HEPATITIS A VIRUS CELLULAR RECEPTOR 2 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;intracellular receptor signaling pathway#GO:0030522;regulation of response to biotic stimulus#GO:0002831;innate immune response-activating signaling pathway#GO:0002758;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;intracellular signal transduction#GO:0035556;regulation of immune response#GO:0050776;regulation of defense response#GO:0031347;positive regulation of response to stimulus#GO:0048584;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;activation of innate immune response#GO:0002218;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of innate immune response#GO:0045089;regulation of innate immune response#GO:0045088;regulation of biosynthetic process#GO:0009889;positive regulation of response to biotic stimulus#GO:0002833;regulation of gene expression#GO:0010468;pattern recognition receptor signaling pathway#GO:0002221;regulation of response to stress#GO:0080134;positive regulation of defense response#GO:0031349;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;signaling#GO:0023052;regulation of biological process#GO:0050789;immune response-regulating signaling pathway#GO:0002764;cytoplasmic pattern recognition receptor signaling pathway#GO:0002753;immune system process#GO:0002376;regulation of response to external stimulus#GO:0032101;positive regulation of immune system process#GO:0002684;activation of immune response#GO:0002253;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;immune response-activating signaling pathway#GO:0002757;positive regulation of response to external stimulus#GO:0032103 nuclear protein-containing complex#GO:0140513;mediator complex#GO:0016592;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;nucleus#GO:0005634 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=15982|UniProtKB=Q8IWT3 Q8IWT3 CUL9 PTHR22771:SF2 CULLIN AND GALACTOSE-BINDING DOMAIN-CONTAINING CULLIN-9 protein complex scaffold activity#GO:0140378;structural molecule activity#GO:0005198 protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;catabolic process#GO:0009056;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of cell cycle#GO:0051726;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;modification-dependent protein catabolic process#GO:0019941;regulation of organelle organization#GO:0033043;macromolecule metabolic process#GO:0043170;regulation of mitotic nuclear division#GO:0007088;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;regulation of cell cycle process#GO:0010564;biological regulation#GO:0065007;regulation of nuclear division#GO:0051783;regulation of mitotic cell cycle#GO:0007346;cellular process#GO:0009987 intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;transferase complex#GO:1990234;catalytic complex#GO:1902494 HUMAN|HGNC=26340|UniProtKB=Q32M84 Q32M84 BTBD16 PTHR46843:SF1 BTB/POZ DOMAIN-CONTAINING PROTEIN 16 BTB_POZ DOMAIN-CONTAINING PROTEIN 16 HUMAN|HGNC=19338|UniProtKB=Q9BWU1 Q9BWU1 CDK19 PTHR24056:SF570 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE 19 phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;cyclin-dependent protein kinase activity#GO:0097472;protein serine/threonine kinase activity#GO:0004674;cyclin-dependent protein serine/threonine kinase activity#GO:0004693;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein kinase complex#GO:1902911;mediator complex#GO:0016592;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;nucleus#GO:0005634;cytosol#GO:0005829 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=14653|UniProtKB=Q9HBI1 Q9HBI1 PARVB PTHR12114:SF7 PARVIN BETA-PARVIN protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;binding#GO:0005488 regulation of anatomical structure morphogenesis#GO:0022603;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection assembly#GO:0120031;substrate adhesion-dependent cell spreading#GO:0034446;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cell projection assembly#GO:0030031;cell-substrate adhesion#GO:0031589;regulation of biological quality#GO:0065008;establishment or maintenance of cell polarity#GO:0007163;actin filament-based process#GO:0030029;cell adhesion#GO:0007155;actin cytoskeleton organization#GO:0030036;cell projection organization#GO:0030030;regulation of developmental process#GO:0050793;cellular component organization#GO:0016043;regulation of cell shape#GO:0008360;lamellipodium assembly#GO:0030032;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cell-substrate junction#GO:0030055;focal adhesion#GO:0005925;actin cytoskeleton#GO:0015629;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;intracellular organelle#GO:0043229;lamellipodium#GO:0030027;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cell leading edge#GO:0031252;membraneless organelle#GO:0043228;cell junction#GO:0030054;cytoskeleton#GO:0005856 actin and actin related protein#PC00039;actin or actin-binding cytoskeletal protein#PC00041 Integrin signalling pathway#P00034>Parvin#P00945 HUMAN|HGNC=17003|UniProtKB=Q9Y6Q2 Q9Y6Q2 STON1 PTHR10529:SF339 AP COMPLEX SUBUNIT MU STONIN-1 cargo adaptor activity#GO:0140312;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 cellular localization#GO:0051641;Golgi to vacuole transport#GO:0006896;localization#GO:0051179;post-Golgi vesicle-mediated transport#GO:0006892;endocytosis#GO:0006897;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;synaptic vesicle endocytosis#GO:0048488;clathrin-dependent endocytosis#GO:0072583;regulation of biological process#GO:0050789;import into cell#GO:0098657;vesicle-mediated transport in synapse#GO:0099003;establishment of localization#GO:0051234;receptor-mediated endocytosis#GO:0006898;regulation of localization#GO:0032879;regulation of transport#GO:0051049;intracellular transport#GO:0046907;transport#GO:0006810;Golgi vesicle transport#GO:0048193;synaptic vesicle cycle#GO:0099504;vacuolar transport#GO:0007034;regulation of endocytosis#GO:0030100;synaptic vesicle recycling#GO:0036465;vesicle-mediated transport#GO:0016192;biological regulation#GO:0065007;cellular process#GO:0009987;establishment of localization in cell#GO:0051649 intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;synaptic vesicle#GO:0008021;plasma membrane protein complex#GO:0098797;vesicle#GO:0031982;membrane coat#GO:0030117;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endomembrane system#GO:0012505;transport vesicle#GO:0030133;plasma membrane#GO:0005886;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;cytosol#GO:0005829;vesicle membrane#GO:0012506;cell periphery#GO:0071944;organelle membrane#GO:0031090;clathrin-coated vesicle#GO:0030136;Golgi apparatus#GO:0005794;synapse#GO:0045202;clathrin coat#GO:0030118;cellular anatomical structure#GO:0110165;organelle#GO:0043226;coated vesicle membrane#GO:0030662;intracellular vesicle#GO:0097708;clathrin-coated pit#GO:0005905;coated membrane#GO:0048475;coated vesicle#GO:0030135;organelle subcompartment#GO:0031984;endocytic vesicle#GO:0030139;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;vesicle coat#GO:0030120;secretory vesicle#GO:0099503;presynapse#GO:0098793;clathrin-coated endocytic vesicle#GO:0045334;clathrin-coated vesicle membrane#GO:0030665;cell junction#GO:0030054;bounding membrane of organelle#GO:0098588;AP-type membrane coat adaptor complex#GO:0030119;clathrin vesicle coat#GO:0030125 membrane traffic protein#PC00150 HUMAN|HGNC=6607|UniProtKB=O75022 O75022 LILRB3 PTHR11738:SF187 MHC CLASS I NK CELL RECEPTOR LEUKOCYTE IMMUNOGLOBULIN-LIKE RECEPTOR SUBFAMILY A MEMBER 6-RELATED immune receptor activity#GO:0140375;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166;signal transduction#GO:0007165;cellular process#GO:0009987;response to chemical#GO:0042221;response to cytokine#GO:0034097;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;cytokine-mediated signaling pathway#GO:0019221;regulation of immune response#GO:0050776;cell communication#GO:0007154;response to peptide#GO:1901652;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;cellular response to stimulus#GO:0051716;immune response-regulating signaling pathway#GO:0002764;response to stimulus#GO:0050896;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;signaling#GO:0023052 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=26320|UniProtKB=Q96LT4 Q96LT4 SAMD8 PTHR21290:SF69 SPHINGOMYELIN SYNTHETASE SPHINGOMYELIN SYNTHASE-RELATED PROTEIN 1 catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, for other substituted phosphate groups#GO:0016780 ceramide biosynthetic process#GO:0046513;lipid metabolic process#GO:0006629;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;sphingolipid biosynthetic process#GO:0030148;ceramide metabolic process#GO:0006672;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;cytoplasm#GO:0005737;plasma membrane#GO:0005886;endomembrane system#GO:0012505;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=437|UniProtKB=P09923 P09923 ALPI PTHR11596:SF30 ALKALINE PHOSPHATASE INTESTINAL-TYPE ALKALINE PHOSPHATASE phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 phosphatase#PC00181;hydrolase#PC00121 HUMAN|HGNC=23685|UniProtKB=Q5VWJ9 Q5VWJ9 SNX30 PTHR45949:SF1 SORTING NEXIN-4 SORTING NEXIN-30 catabolic process#GO:0009056;endocytic recycling#GO:0032456;piecemeal microautophagy of the nucleus#GO:0034727;cellular localization#GO:0051641;localization#GO:0051179;protein transport#GO:0015031;process utilizing autophagic mechanism#GO:0061919;localization within membrane#GO:0051668;vesicle-mediated transport#GO:0016192;macroautophagy#GO:0016236;reticulophagy#GO:0061709;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;autophagy#GO:0006914;establishment of protein localization#GO:0045184;establishment of localization#GO:0051234;mitophagy#GO:0000423;endosomal transport#GO:0016197;intracellular protein localization#GO:0008104;vesicle-mediated transport to the plasma membrane#GO:0098876;intracellular transport#GO:0046907;autophagy of mitochondrion#GO:0000422;metabolic process#GO:0008152;transport#GO:0006810 early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;phagophore assembly site#GO:0000407;endosome#GO:0005768;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982 scaffold/adaptor protein#PC00226 HUMAN|HGNC=16209|UniProtKB=Q9NQG5 Q9NQG5 RPRD1B PTHR12460:SF3 CYCLIN-DEPENDENT KINASE INHIBITOR-RELATED PROTEIN REGULATION OF NUCLEAR PRE-MRNA DOMAIN-CONTAINING PROTEIN 1B RNA polymerase II complex binding#GO:0000993;protein binding#GO:0005515;RNA polymerase core enzyme binding#GO:0043175;binding#GO:0005488;enzyme binding#GO:0019899;RNA polymerase binding#GO:0070063 RNA 3'-end processing#GO:0031123;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;mRNA 3'-end processing#GO:0031124;gene expression#GO:0010467;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 protein-binding activity modulator#PC00095;kinase inhibitor#PC00139 HUMAN|HGNC=11499|UniProtKB=O43760 O43760 SYNGR2 PTHR10838:SF30 SYNAPTOGYRIN SYNAPTOGYRIN-2 cellular process#GO:0009987;cellular component organization#GO:0016043;synaptic vesicle membrane organization#GO:0048499;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;export from cell#GO:0140352;vesicle-mediated transport#GO:0016192;transport#GO:0006810;regulated exocytosis#GO:0045055;exocytosis#GO:0006887;secretion by cell#GO:0032940;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;secretion#GO:0046903;establishment of localization#GO:0051234 cytoplasm#GO:0005737;endomembrane system#GO:0012505;transport vesicle#GO:0030133;presynapse#GO:0098793;secretory vesicle#GO:0099503;cell junction#GO:0030054;intracellular membrane-bounded organelle#GO:0043231;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;synaptic vesicle#GO:0008021;vesicle#GO:0031982;intracellular vesicle#GO:0097708;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229 membrane traffic protein#PC00150;membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=34517|UniProtKB=A6NCQ9 A6NCQ9 RNF222 PTHR47095:SF1 RING FINGER PROTEIN 222 RING FINGER PROTEIN 222 HUMAN|HGNC=14340|UniProtKB=Q9UBQ0 Q9UBQ0 VPS29 PTHR11124:SF12 VACUOLAR SORTING PROTEIN VPS29 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 29 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;cargo adaptor activity#GO:0140312 retrograde transport, endosome to Golgi#GO:0042147;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;cytosolic transport#GO:0016482;intracellular transport#GO:0046907;transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;endosomal transport#GO:0016197 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;retromer complex#GO:0030904;vesicle#GO:0031982;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endosome#GO:0005768;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;membrane#GO:0016020 vesicle coat protein#PC00235 HUMAN|HGNC=25074|UniProtKB=O43325 O43325 LYRM1 PTHR14273:SF0 LYR MOTIF-CONTAINING PROTEIN 1 LYR MOTIF-CONTAINING PROTEIN 1 HUMAN|HGNC=30238|UniProtKB=Q5T9L3 Q5T9L3 WLS PTHR13449:SF2 INTEGRAL MEMBRANE PROTEIN GPR177 PROTEIN WNTLESS HOMOLOG binding#GO:0005488;Wnt-protein binding#GO:0017147;protein binding#GO:0005515 establishment of protein localization to extracellular region#GO:0035592;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;macromolecule localization#GO:0033036;protein transport#GO:0015031;secretion by cell#GO:0032940;cellular localization#GO:0051641;secretion#GO:0046903;protein secretion#GO:0009306;cell communication#GO:0007154;localization#GO:0051179;signal release#GO:0023061;export from cell#GO:0140352;signaling#GO:0023052;protein localization to extracellular region#GO:0071692;regulation of biological process#GO:0050789 membrane#GO:0016020;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090 HUMAN|HGNC=6653|UniProtKB=Q8TE12 Q8TE12 LMX1A PTHR24208:SF88 LIM/HOMEOBOX PROTEIN LHX LIM HOMEOBOX TRANSCRIPTION FACTOR 1-ALPHA sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;developmental process#GO:0032502;neuron differentiation#GO:0030182;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;nervous system development#GO:0007399;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;cellular process#GO:0009987;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119 HUMAN|HGNC=37229|UniProtKB=A6NEM1 A6NEM1 GOLGA6L9 PTHR23143:SF19 TRICHOHYALIN-RELATED GOLGIN A6 FAMILY LIKE 10-RELATED actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=4679|UniProtKB=Q9UMX6 Q9UMX6 GUCA1B PTHR23055:SF11 CALCIUM BINDING PROTEINS GUANYLYL CYCLASE-ACTIVATING PROTEIN 2 molecular function activator activity#GO:0140677;cation binding#GO:0043169;metal ion binding#GO:0046872;enzyme regulator activity#GO:0030234;calcium ion binding#GO:0005509;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;molecular function regulator activity#GO:0098772;cyclase regulator activity#GO:0010851;enzyme activator activity#GO:0008047 system process#GO:0003008;visual perception#GO:0007601;multicellular organismal process#GO:0032501;sensory perception#GO:0007600;nervous system process#GO:0050877;sensory perception of light stimulus#GO:0050953 membrane-bounded organelle#GO:0043227;non-motile cilium#GO:0097730;cilium#GO:0005929;photoreceptor inner segment#GO:0001917;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;photoreceptor outer segment#GO:0001750;cellular anatomical structure#GO:0110165;neuron projection#GO:0043005;photoreceptor cell cilium#GO:0097733;9+0 non-motile cilium#GO:0097731 calmodulin-related#PC00061 HUMAN|HGNC=29380|UniProtKB=Q96ME7 Q96ME7 ZNF512 PTHR22979:SF2 ZINC FINGER PROTEIN-RELATED ZINC FINGER PROTEIN 512 HUMAN|HGNC=6619|UniProtKB=P11150 P11150 LIPC PTHR11610:SF2 LIPASE HEPATIC TRIACYLGLYCEROL LIPASE hydrolase activity#GO:0016787;protein binding#GO:0005515;hydrolase activity, acting on ester bonds#GO:0016788;lipase activity#GO:0016298;binding#GO:0005488;catalytic activity#GO:0003824 catabolic process#GO:0009056;lipid catabolic process#GO:0016042;cellular process#GO:0009987;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;primary metabolic process#GO:0044238 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 lipase#PC00143;metabolite interconversion enzyme#PC00262;hydrolase#PC00121 Triacylglycerol metabolism#P02782>Triacylglycerol lipase#P03205 HUMAN|HGNC=5010|UniProtKB=P17096 P17096 HMGA1 PTHR23341:SF1 HIGH MOBILITY GROUP PROTEINS HMG-A AND C HIGH MOBILITY GROUP PROTEIN HMG-I_HMG-Y transcription regulator activity#GO:0140110;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription coregulator activity#GO:0003712;DNA binding#GO:0003677 regulation of DNA-templated transcription#GO:0006355;cell communication#GO:0007154;regulation of RNA metabolic process#GO:0051252;intracellular signal transduction#GO:0035556;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;signaling#GO:0023052;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HMG box transcription factor#PC00024 HUMAN|HGNC=40045|UniProtKB=Q6UWS5 Q6UWS5 PET117 PTHR28163:SF1 PROTEIN PET117 HOMOLOG, MITOCHONDRIAL PROTEIN PET117 HOMOLOG, MITOCHONDRIAL cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;respiratory chain complex IV assembly#GO:0008535;mitochondrial respiratory chain complex IV assembly#GO:0033617;cytochrome complex assembly#GO:0017004;cellular component assembly#GO:0022607;mitochondrial respiratory chain complex assembly#GO:0033108;mitochondrion organization#GO:0007005;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=21219|UniProtKB=Q9UPZ9 Q9UPZ9 CILK1 PTHR24055:SF260 MITOGEN-ACTIVATED PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE ICK catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cell projection assembly#GO:0030031;establishment of localization in cell#GO:0051649;signal transduction#GO:0007165;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cilium organization#GO:0044782;cellular localization#GO:0051641;microtubule-based transport#GO:0099111;signaling#GO:0023052;cell projection organization#GO:0030030;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;cilium assembly#GO:0060271;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;transport#GO:0006810;plasma membrane bounded cell projection assembly#GO:0120031;intracellular transport#GO:0046907;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton-dependent intracellular transport#GO:0030705;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;localization#GO:0051179;organelle assembly#GO:0070925;intraciliary transport#GO:0042073;regulation of cellular process#GO:0050794;microtubule-based movement#GO:0007018;cellular response to stimulus#GO:0051716 cilium#GO:0005929;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=17380|UniProtKB=Q9UJX3 Q9UJX3 ANAPC7 PTHR12558:SF36 CELL DIVISION CYCLE 16,23,27 ANAPHASE-PROMOTING COMPLEX SUBUNIT 7 enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 regulation of chromosome organization#GO:0033044;regulation of mitotic nuclear division#GO:0007088;positive regulation of mitotic cell cycle#GO:0045931;macromolecule metabolic process#GO:0043170;regulation of mitotic sister chromatid separation#GO:0010965;positive regulation of cellular process#GO:0048522;regulation of mitotic cell cycle#GO:0007346;biological regulation#GO:0065007;regulation of nuclear division#GO:0051783;post-translational protein modification#GO:0043687;regulation of mitotic metaphase/anaphase transition#GO:0030071;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;cell division#GO:0051301;regulation of cell cycle phase transition#GO:1901987;primary metabolic process#GO:0044238;protein modification process#GO:0036211;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;regulation of cellular process#GO:0050794;regulation of chromosome segregation#GO:0051983;positive regulation of mitotic nuclear division#GO:0045840;metabolic process#GO:0008152;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of cell cycle process#GO:0010564;protein ubiquitination#GO:0016567;positive regulation of cell cycle#GO:0045787;regulation of chromosome separation#GO:1905818;positive regulation of cellular component organization#GO:0051130;protein modification by small protein conjugation or removal#GO:0070647;regulation of mitotic cell cycle phase transition#GO:1901990;positive regulation of organelle organization#GO:0010638;positive regulation of cell cycle process#GO:0090068;protein modification by small protein conjugation#GO:0032446;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;regulation of cell cycle#GO:0051726;regulation of sister chromatid segregation#GO:0033045;regulation of cellular component organization#GO:0051128 nucleus#GO:0005634;protein-containing complex#GO:0032991;anaphase-promoting complex#GO:0005680;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;nuclear ubiquitin ligase complex#GO:0000152;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ubiquitin ligase complex#GO:0000151;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=18458|UniProtKB=Q9BWX1 Q9BWX1 PHF7 PTHR12420:SF47 PHD FINGER PROTEIN E3 UBIQUITIN-PROTEIN LIGASE PHF7 ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA metabolism protein#PC00009 HUMAN|HGNC=30172|UniProtKB=Q7RTN6 Q7RTN6 STRADA PTHR48014:SF20 SERINE/THREONINE-PROTEIN KINASE FRAY2 STE20-RELATED KINASE ADAPTER PROTEIN ALPHA molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;kinase activator activity#GO:0019209;protein kinase regulator activity#GO:0019887;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;protein kinase activator activity#GO:0030295;protein serine/threonine kinase activator activity#GO:0043539;enzyme activator activity#GO:0008047 nucleocytoplasmic transport#GO:0006913;cellular localization#GO:0051641;localization#GO:0051179;nuclear export#GO:0051168;protein transport#GO:0015031;nuclear transport#GO:0051169;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;protein export from nucleus#GO:0006611;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104 serine/threonine protein kinase complex#GO:1902554;protein kinase complex#GO:1902911;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;transferase complex#GO:1990234;transferase complex, transferring phosphorus-containing groups#GO:0061695 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=8754|UniProtKB=P49585 P49585 PCYT1A PTHR10739:SF19 CYTIDYLYLTRANSFERASE CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE A transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;phospholipid binding#GO:0005543;transferase activity#GO:0016740;nucleotidyltransferase activity#GO:0016779;phosphatidylcholine binding#GO:0031210;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;cation binding#GO:0043169;lipid binding#GO:0008289 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 transferase#PC00220 HUMAN|HGNC=5897|UniProtKB=A0A075B6K4 A0A075B6K4 IGLV3-10 PTHR23267:SF496 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN LAMBDA VARIABLE 3-10 response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=24522|UniProtKB=Q8NBN3 Q8NBN3 TMEM87A PTHR21229:SF19 LUNG SEVEN TRANSMEMBRANE RECEPTOR GOLGI-PH REGULATING CATION CHANNEL transport#GO:0006810;intracellular transport#GO:0046907;endosomal transport#GO:0016197;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;retrograde transport, endosome to Golgi#GO:0042147;cytosolic transport#GO:0016482;vesicle-mediated transport#GO:0016192 organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;Golgi cisterna#GO:0031985;organelle#GO:0043226;Golgi stack#GO:0005795;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=28384|UniProtKB=Q5JPI3 Q5JPI3 C3orf38 PTHR21084:SF1 DENSE INCISORS SIMILAR TO HUMAN CHROMOSOME 3 OPEN READING FRAME 38 HUMAN|HGNC=25370|UniProtKB=Q8IV38 Q8IV38 ANKMY2 PTHR24150:SF8 ANKYRIN REPEAT AND MYND DOMAIN-CONTAINING PROTEIN 2 ANKYRIN REPEAT AND MYND DOMAIN-CONTAINING PROTEIN 2 HUMAN|HGNC=16260|UniProtKB=Q8IXA5 Q8IXA5 SPACA3 PTHR11407:SF25 LYSOZYME C SPERM ACROSOME MEMBRANE-ASSOCIATED PROTEIN 3 peptidoglycan muralytic activity#GO:0061783;catalytic activity#GO:0003824;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;lysozyme activity#GO:0003796 multicellular organismal reproductive process#GO:0048609;sexual reproduction#GO:0019953;cellular process involved in reproduction in multicellular organism#GO:0022412;reproductive process#GO:0022414;fertilization#GO:0009566;fusion of sperm to egg plasma membrane involved in single fertilization#GO:0007342;cellular process#GO:0009987;single fertilization#GO:0007338 sperm flagellum#GO:0036126;endomembrane system#GO:0012505;cytoplasm#GO:0005737;secretory vesicle#GO:0099503;cellular anatomical structure#GO:0110165;motile cilium#GO:0031514;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;intracellular vesicle#GO:0097708;vesicle#GO:0031982;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;acrosomal vesicle#GO:0001669;intracellular organelle#GO:0043229;cilium#GO:0005929;9+2 motile cilium#GO:0097729 glycosidase#PC00110 HUMAN|HGNC=4125|UniProtKB=Q14435 Q14435 GALNT3 PTHR11675:SF33 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 3 polypeptide N-acetylgalactosaminyltransferase activity#GO:0004653;hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;acetylgalactosaminyltransferase activity#GO:0008376 carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein O-linked glycosylation#GO:0006493;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 glycosyltransferase#PC00111;transferase#PC00220 HUMAN|HGNC=1133|UniProtKB=Q06187 Q06187 BTK PTHR24418:SF92 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE BTK protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;non-membrane spanning protein tyrosine kinase activity#GO:0004715;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;catalytic activity#GO:0003824 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 non-receptor tyrosine protein kinase#PC00168 B cell activation#P00010>Btk#P00400 HUMAN|HGNC=31696|UniProtKB=Q6ZSG1 Q6ZSG1 ARK2C PTHR22937:SF233 E3 UBIQUITIN-PROTEIN LIGASE RNF165 E3 UBIQUITIN-PROTEIN LIGASE ARK2C ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;catabolic process#GO:0009056;regulation of cell communication#GO:0010646;primary metabolic process#GO:0044238;positive regulation of signal transduction#GO:0009967;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092;modification-dependent protein catabolic process#GO:0019941;anatomical structure development#GO:0048856;protein metabolic process#GO:0019538;system development#GO:0048731;multicellular organismal process#GO:0032501;positive regulation of response to stimulus#GO:0048584;plasma membrane bounded cell projection organization#GO:0120036;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cellular response to growth factor stimulus#GO:0090287;axon guidance#GO:0007411;axon development#GO:0061564;regulation of BMP signaling pathway#GO:0030510;positive regulation of cellular process#GO:0048522;cellular developmental process#GO:0048869;macromolecule metabolic process#GO:0043170;neurogenesis#GO:0022008;ubiquitin-dependent protein catabolic process#GO:0006511;neuron projection guidance#GO:0097485;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;neuron projection morphogenesis#GO:0048812;regulation of response to stimulus#GO:0048583;developmental process#GO:0032502;cell morphogenesis#GO:0000902;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell development#GO:0048468;cellular component organization#GO:0016043;motor neuron axon guidance#GO:0008045;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;positive regulation of signaling#GO:0023056;axonogenesis#GO:0007409;neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;modification-dependent macromolecule catabolic process#GO:0043632;regulation of signaling#GO:0023051;protein catabolic process#GO:0030163;generation of neurons#GO:0048699;nervous system development#GO:0007399;proteasomal protein catabolic process#GO:0010498;cell morphogenesis involved in neuron differentiation#GO:0048667;neuron projection development#GO:0031175;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;positive regulation of BMP signaling pathway#GO:0030513;cell projection morphogenesis#GO:0048858;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=20533|UniProtKB=P60413 P60413 KRTAP10-12 PTHR23262:SF233 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 10-12 structural protein#PC00211 HUMAN|HGNC=14584|UniProtKB=Q9H269 Q9H269 VPS16 PTHR12811:SF3 VACUOLAR PROTEIN SORTING VPS16 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;protein binding#GO:0005515 cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;endosomal transport#GO:0016197;intracellular transport#GO:0046907;transport#GO:0006810;organelle fusion#GO:0048284;vesicle-mediated transport#GO:0016192;vacuole fusion, non-autophagic#GO:0042144;organelle organization#GO:0006996;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;localization#GO:0051179;cellular localization#GO:0051641;vacuole organization#GO:0007033;vacuole fusion#GO:0097576;cellular component organization#GO:0016043 protein-containing complex#GO:0032991;endomembrane system#GO:0012505;vacuole#GO:0005773;cytoplasm#GO:0005737;membrane#GO:0016020;lysosomal membrane#GO:0005765;lytic vacuole#GO:0000323;vacuolar membrane#GO:0005774;vesicle tethering complex#GO:0099023;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;lytic vacuole membrane#GO:0098852;intracellular vesicle#GO:0097708;vesicle#GO:0031982;lysosome#GO:0005764;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768 membrane traffic protein#PC00150 HUMAN|HGNC=894|UniProtKB=P01185 P01185 AVP PTHR11681:SF9 NEUROPHYSIN VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;neuropeptide hormone activity#GO:0005184;G protein-coupled receptor binding#GO:0001664;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;molecular function activator activity#GO:0140677;hormone activity#GO:0005179;protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 regulation of biological quality#GO:0065008;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;circulatory system process#GO:0003013;signaling#GO:0023052;regulation of cellular process#GO:0050794;positive regulation of blood pressure#GO:0045777;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;positive regulation of multicellular organismal process#GO:0051240;regulation of biological process#GO:0050789;system process#GO:0003008;regulation of system process#GO:0044057;regulation of anatomical structure size#GO:0090066;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;blood circulation#GO:0008015;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;regulation of systemic arterial blood pressure#GO:0003073;regulation of blood pressure#GO:0008217 extracellular region#GO:0005576;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;secretory vesicle#GO:0099503;intracellular vesicle#GO:0097708;vesicle#GO:0031982;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 peptide hormone#PC00179;neuropeptide#PC00162 Vasopressin synthesis#P04395>Pro-Vasopressin#P04598;Vasopressin synthesis#P04395>Pro2-Vasopressin#P04595;Vasopressin synthesis#P04395>Neurophysin#P04594;Vasopressin synthesis#P04395>Signal Peptide#P04597;Vasopressin synthesis#P04395>Glycopeptide#P04593;Opioid prodynorphin pathway#P05916>prepropressophysin#G06050;Opioid prodynorphin pathway#P05916>vasopressin#P06000;Vasopressin synthesis#P04395>Vasopressin#P04590;Opioid prodynorphin pathway#P05916>provasopressin#P05999;Vasopressin synthesis#P04395>Pro-Neurophysin#P04591;Opioid prodynorphin pathway#P05916>prepropressophysin#G06048 HUMAN|HGNC=18303|UniProtKB=Q9UI12 Q9UI12 ATP6V1H PTHR10698:SF7 V-TYPE PROTON ATPASE SUBUNIT H V-TYPE PROTON ATPASE SUBUNIT H synaptic vesicle cycle#GO:0099504;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;developmental process#GO:0032502;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;vacuolar acidification#GO:0007035;establishment of localization#GO:0051234;proton transmembrane transport#GO:1902600;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;developmental maturation#GO:0021700;regulation of intracellular pH#GO:0051453;regulation of pH#GO:0006885;monoatomic cation transport#GO:0006812;localization#GO:0051179;homeostatic process#GO:0042592;chemical homeostasis#GO:0048878;vesicle organization#GO:0016050;vesicle-mediated transport in synapse#GO:0099003;synaptic vesicle maturation#GO:0016188;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;monoatomic ion homeostasis#GO:0050801;organelle organization#GO:0006996;monoatomic cation transmembrane transport#GO:0098655;vesicle-mediated transport#GO:0016192;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;cellular localization#GO:0051641;transmembrane transport#GO:0055085;cellular component organization#GO:0016043;intracellular monoatomic ion homeostasis#GO:0006873 ATPase complex#GO:1904949;vacuolar proton-transporting V-type ATPase complex#GO:0016471;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transmembrane transporter complex#GO:1902495;ATPase dependent transmembrane transport complex#GO:0098533;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane protein complex#GO:0098796;cation-transporting ATPase complex#GO:0090533;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vacuolar proton-transporting V-type ATPase, V1 domain#GO:0000221;intracellular membrane-bounded organelle#GO:0043231;proton-transporting two-sector ATPase complex#GO:0016469;transporter complex#GO:1990351;vacuolar membrane#GO:0005774;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;proton-transporting V-type ATPase complex#GO:0033176;membrane#GO:0016020;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;vacuole#GO:0005773 primary active transporter#PC00068;ATP synthase#PC00002 HUMAN|HGNC=4419|UniProtKB=P01148 P01148 GNRH1 PTHR10522:SF0 GONADOLIBERIN PROGONADOLIBERIN-1 protein binding#GO:0005515;hormone activity#GO:0005179;molecular function activator activity#GO:0140677;hormone receptor binding#GO:0051427;signaling receptor binding#GO:0005102;binding#GO:0005488;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018 biological regulation#GO:0065007;regulation of biological process#GO:0050789;regulation of signaling#GO:0023051 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207;peptide hormone#PC00179 Gonadotropin-releasing hormone receptor pathway#P06664>GnRH#P06704 HUMAN|HGNC=1543|UniProtKB=P23435 P23435 CBLN1 PTHR22923:SF5 CEREBELLIN-RELATED CEREBELLIN-1 extracellular region#GO:0005576;synapse#GO:0045202;glutamatergic synapse#GO:0098978;cellular anatomical structure#GO:0110165;cell junction#GO:0030054 scaffold/adaptor protein#PC00226 HUMAN|HGNC=29112|UniProtKB=Q6DN90 Q6DN90 IQSEC1 PTHR10663:SF327 GUANYL-NUCLEOTIDE EXCHANGE FACTOR IQ MOTIF AND SEC7 DOMAIN-CONTAINING PROTEIN 1 regulation of cellular component organization#GO:0051128;regulation of receptor-mediated endocytosis#GO:0048259;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;regulation of localization#GO:0032879;regulation of transport#GO:0051049;regulation of biological quality#GO:0065008;regulation of endocytosis#GO:0030100 cell junction#GO:0030054;synaptic membrane#GO:0097060;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;neuron to neuron synapse#GO:0098984;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;postsynaptic density membrane#GO:0098839;postsynaptic specialization membrane#GO:0099634;postsynaptic membrane#GO:0045211;postsynaptic density#GO:0014069;asymmetric synapse#GO:0032279;organelle#GO:0043226;cellular anatomical structure#GO:0110165;synapse#GO:0045202;postsynapse#GO:0098794 guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=13993|UniProtKB=Q9NQV8 Q9NQV8 PRDM8 PTHR16516:SF7 AGAP007109-PA PR DOMAIN ZINC FINGER PROTEIN 8 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=28261|UniProtKB=Q8TEA7 Q8TEA7 TBCK PTHR22957:SF168 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN TBC DOMAIN-CONTAINING PROTEIN KINASE-LIKE PROTEIN molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047 protein-binding activity modulator#PC00095;G-protein modulator#PC00022;GTPase-activating protein#PC00257 HUMAN|HGNC=16370|UniProtKB=Q9H4L5 Q9H4L5 OSBPL3 PTHR10972:SF15 OXYSTEROL-BINDING PROTEIN-RELATED OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 3 alcohol binding#GO:0043178;steroid binding#GO:0005496;lipid binding#GO:0008289;cholesterol binding#GO:0015485;small molecule binding#GO:0036094;binding#GO:0005488;sterol binding#GO:0032934 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;organelle membrane#GO:0031090;nuclear membrane#GO:0031965;cell periphery#GO:0071944;nucleus#GO:0005634;membrane#GO:0016020;cytosol#GO:0005829;cytoplasm#GO:0005737;plasma membrane#GO:0005886;perinuclear region of cytoplasm#GO:0048471;nuclear envelope#GO:0005635;endomembrane system#GO:0012505 transfer/carrier protein#PC00219 HUMAN|HGNC=6074|UniProtKB=Q96PE3 Q96PE3 INPP4A PTHR12187:SF4 AGAP000124-PA INOSITOL POLYPHOSPHATE-4-PHOSPHATASE TYPE I A phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791 regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cell communication#GO:0010646;regulation of biological process#GO:0050789;regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051896;regulation of biological quality#GO:0065008;regulation of intracellular signal transduction#GO:1902531;regulation of postsynaptic membrane neurotransmitter receptor levels#GO:0099072;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051 postsynaptic density#GO:0014069;cell junction#GO:0030054;membrane#GO:0016020;postsynapse#GO:0098794;neuron to neuron synapse#GO:0098984;synapse#GO:0045202;cellular anatomical structure#GO:0110165;glutamatergic synapse#GO:0098978;asymmetric synapse#GO:0032279;postsynaptic specialization#GO:0099572;organelle#GO:0043226 phosphatase#PC00181 HUMAN|HGNC=8674|UniProtKB=Q9Y5H6 Q9Y5H6 PCDHA8 PTHR24028:SF305 CADHERIN-87A PROTOCADHERIN ALPHA-6-RELATED cellular process#GO:0009987;cell adhesion#GO:0007155 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HUMAN|HGNC=41915|UniProtKB=A6NGZ8 A6NGZ8 SMIM9 PTHR41687:SF1 SMALL INTEGRAL MEMBRANE PROTEIN 9 SMALL INTEGRAL MEMBRANE PROTEIN 9 HUMAN|HGNC=14921|UniProtKB=Q9NYV7 Q9NYV7 TAS2R16 PTHR11394:SF68 TASTE RECEPTOR TYPE 2 TASTE RECEPTOR TYPE 2 MEMBER 16 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;taste receptor activity#GO:0008527;bitter taste receptor activity#GO:0033038;molecular transducer activity#GO:0060089 sensory perception of bitter taste#GO:0050913;detection of chemical stimulus#GO:0009593;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;response to stimulus#GO:0050896;response to chemical#GO:0042221;multicellular organismal process#GO:0032501;sensory perception#GO:0007600;nervous system process#GO:0050877;detection of chemical stimulus involved in sensory perception of taste#GO:0050912;sensory perception of taste#GO:0050909;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;detection of chemical stimulus involved in sensory perception of bitter taste#GO:0001580 cellular anatomical structure#GO:0110165;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=24566|UniProtKB=Q5T6S3 Q5T6S3 PHF19 PTHR12628:SF6 POLYCOMB-LIKE TRANSCRIPTION FACTOR PHD FINGER PROTEIN 19 nucleic acid binding#GO:0003676;binding#GO:0005488;chromatin binding#GO:0003682;DNA binding#GO:0003677 negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;negative regulation of gene expression, epigenetic#GO:0045814;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of metabolic process#GO:0019222;epigenetic regulation of gene expression#GO:0040029;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;chromatin organization#GO:0006325;negative regulation of biosynthetic process#GO:0009890;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 gene-specific transcriptional regulator#PC00264;helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=12695|UniProtKB=P41587 P41587 VIPR2 PTHR45620:SF22 PDF RECEPTOR-LIKE PROTEIN-RELATED VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 2 molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=18874|UniProtKB=O43561 O43561 LAT PTHR15586:SF0 LINKER FOR ACTIVATION OF T-CELLS FAMILY MEMBER 1 LINKER FOR ACTIVATION OF T-CELLS FAMILY MEMBER 1 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;signaling receptor complex adaptor activity#GO:0030159;signaling adaptor activity#GO:0035591 response to stimulus#GO:0050896;signaling#GO:0023052;regulation of lymphocyte activation#GO:0051249;regulation of leukocyte activation#GO:0002694;regulation of biological process#GO:0050789;immune response-regulating signaling pathway#GO:0002764;regulation of cell activation#GO:0050865;immune system process#GO:0002376;antigen receptor-mediated signaling pathway#GO:0050851;regulation of T cell activation#GO:0050863;regulation of multicellular organismal process#GO:0051239;positive regulation of immune system process#GO:0002684;response to stress#GO:0006950;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;signal transduction#GO:0007165;cellular process#GO:0009987;immune response-activating signaling pathway#GO:0002757;cell surface receptor signaling pathway#GO:0007166;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;immune response-activating cell surface receptor signaling pathway#GO:0002429;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;inflammatory response#GO:0006954;regulation of immune response#GO:0050776;positive regulation of response to stimulus#GO:0048584;immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007;immune response#GO:0006955;defense response#GO:0006952;T cell receptor signaling pathway#GO:0050852;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 T cell activation#P00053>LAT#P01325 HUMAN|HGNC=27596|UniProtKB=Q6ZMC9 Q6ZMC9 SIGLEC15 PTHR46942:SF1 SIALIC ACID-BINDING IG-LIKE LECTIN 15 SIALIC ACID-BINDING IG-LIKE LECTIN 15 regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;regulation of developmental process#GO:0050793;regulation of multicellular organismal development#GO:2000026;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of hemopoiesis#GO:1903706;regulation of tissue remodeling#GO:0034103;regulation of bone resorption#GO:0045124;regulation of actin cytoskeleton organization#GO:0032956;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;regulation of bone remodeling#GO:0046850;regulation of cell development#GO:0060284;regulation of actin filament-based process#GO:0032970;regulation of cell differentiation#GO:0045595 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=22222|UniProtKB=Q9C0H2 Q9C0H2 TTYH3 PTHR12424:SF4 TWEETY-RELATED PROTEIN TWEETY HOMOLOG 3 monoatomic anion channel activity#GO:0005253;channel activity#GO:0015267;gated channel activity#GO:0022836;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated channel activity#GO:0022834;chloride transmembrane transporter activity#GO:0015108;passive transmembrane transporter activity#GO:0022803;chloride channel activity#GO:0005254;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic anion transmembrane transporter activity#GO:0008509 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=14300|UniProtKB=Q96S65 Q96S65 CSRNP1 PTHR13580:SF10 TGF-BETA INDUCED APOPTOSIS PROTEIN CYSTEINE_SERINE-RICH NUCLEAR PROTEIN 1 DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription regulator activity#GO:0140110;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=25488|UniProtKB=Q9NW97 Q9NW97 TMEM51 PTHR16015:SF0 TRANSMEMBRANE PROTEIN 51 TRANSMEMBRANE PROTEIN 51 HUMAN|HGNC=28062|UniProtKB=Q08AN1 Q08AN1 ZNF616 PTHR24377:SF625 IP01015P-RELATED ZINC FINGER PROTEIN 347-RELATED DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=12955|UniProtKB=Q9P0L1 Q9P0L1 ZKSCAN7 PTHR24377:SF882 IP01015P-RELATED ZINC FINGER PROTEIN WITH KRAB AND SCAN DOMAINS 7 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=19354|UniProtKB=O75182 O75182 SIN3B PTHR12346:SF1 SIN3B-RELATED PAIRED AMPHIPATHIC HELIX PROTEIN SIN3B transcription regulator activity#GO:0140110;transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712 regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 membrane-enclosed lumen#GO:0031974;histone deacetylase complex#GO:0000118;nucleus#GO:0005634;chromatin#GO:0000785;protein-containing complex#GO:0032991;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;organelle lumen#GO:0043233;chromosome#GO:0005694;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;Sin3-type complex#GO:0070822;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 chromatin/chromatin-binding, or -regulatory protein#PC00077 Huntington disease#P00029>Sin3A#P00771 HUMAN|HGNC=16352|UniProtKB=Q9UI43 Q9UI43 MRM2 PTHR10920:SF18 RIBOSOMAL RNA METHYLTRANSFERASE RRNA METHYLTRANSFERASE 2, MITOCHONDRIAL transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring one-carbon groups#GO:0016741;RNA methyltransferase activity#GO:0008173;catalytic activity, acting on RNA#GO:0140098;rRNA methyltransferase activity#GO:0008649;O-methyltransferase activity#GO:0008171;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;catalytic activity, acting on a rRNA#GO:0140102 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;organelle assembly#GO:0070925;rRNA processing#GO:0006364;protein-RNA complex assembly#GO:0022618;macromolecule modification#GO:0043412;RNA methylation#GO:0001510;macromolecule biosynthetic process#GO:0009059;ribosomal large subunit assembly#GO:0000027;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;rRNA metabolic process#GO:0016072;macromolecule metabolic process#GO:0043170;rRNA modification#GO:0000154;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;ribonucleoprotein complex biogenesis#GO:0022613;macromolecule methylation#GO:0043414;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;ribosomal large subunit biogenesis#GO:0042273;ribosome assembly#GO:0042255;ribosome biogenesis#GO:0042254;RNA metabolic process#GO:0016070;methylation#GO:0032259;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;RNA processing#GO:0006396;cellular component assembly#GO:0022607;gene expression#GO:0010467;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;protein-RNA complex organization#GO:0071826;rRNA methylation#GO:0031167 RNA methyltransferase#PC00033 HUMAN|HGNC=27005|UniProtKB=Q5VT99 Q5VT99 LRRC38 PTHR46473:SF4 GH08155P LEUCINE-RICH REPEAT-CONTAINING PROTEIN 38 ion channel regulator activity#GO:0099106;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261;molecular function regulator activity#GO:0098772;transporter regulator activity#GO:0141108;potassium channel activity#GO:0005267;transmembrane transporter binding#GO:0044325;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;channel regulator activity#GO:0016247;transporter activity#GO:0005215;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;binding#GO:0005488;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;potassium channel regulator activity#GO:0015459;protein binding#GO:0005515;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;molecular function activator activity#GO:0140677 cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;cation channel complex#GO:0034703;voltage-gated potassium channel complex#GO:0008076 HUMAN|HGNC=7377|UniProtKB=Q9UJ68 Q9UJ68 MSRA PTHR42799:SF2 MITOCHONDRIAL PEPTIDE METHIONINE SULFOXIDE REDUCTASE MITOCHONDRIAL PEPTIDE METHIONINE SULFOXIDE REDUCTASE oxidoreductase activity#GO:0016491;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667 response to oxidative stress#GO:0006979;cellular response to chemical stress#GO:0062197;cellular response to chemical stimulus#GO:0070887;cellular response to stress#GO:0033554;response to chemical#GO:0042221;response to stimulus#GO:0050896;cellular response to oxidative stress#GO:0034599;response to stress#GO:0006950;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;reductase#PC00198 HUMAN|HGNC=10416|UniProtKB=P42677 P42677 RPS27 PTHR11594:SF1 40S RIBOSOMAL PROTEIN S27 SMALL RIBOSOMAL SUBUNIT PROTEIN ES27 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 ribosome biogenesis#GO:0042254;translation#GO:0006412;nucleic acid biosynthetic process#GO:0141187;protein metabolic process#GO:0019538;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;protein biosynthetic process#GO:0160307;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytosolic small ribosomal subunit#GO:0022627;ribonucleoprotein complex#GO:1990904;small ribosomal subunit#GO:0015935;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;cytosol#GO:0005829;cytosolic ribosome#GO:0022626;ribosome#GO:0005840 translational protein#PC00263;ribosomal protein#PC00202 HUMAN|HGNC=23714|UniProtKB=Q6ZNH5 Q6ZNH5 ZNF497 PTHR24404:SF50 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 497 double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218 HUMAN|HGNC=636|UniProtKB=Q92482 Q92482 AQP3 PTHR43829:SF7 AQUAPORIN OR AQUAGLYCEROPORIN RELATED AQUAPORIN-3 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;water transmembrane transporter activity#GO:0005372;water channel activity#GO:0015250;passive transmembrane transporter activity#GO:0022803;carbohydrate transmembrane transporter activity#GO:0015144;channel activity#GO:0015267 cellular process#GO:0009987;carbohydrate transmembrane transport#GO:0034219;transport#GO:0006810;carbohydrate transport#GO:0008643;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;water transport#GO:0006833;fluid transport#GO:0042044;organic hydroxy compound transport#GO:0015850 cell periphery#GO:0071944;basal plasma membrane#GO:0009925;membrane#GO:0016020;basolateral plasma membrane#GO:0016323;basal part of cell#GO:0045178;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590 transporter#PC00227 HUMAN|HGNC=20877|UniProtKB=Q9H7R0 Q9H7R0 ZNF442 PTHR24379:SF6 KRAB AND ZINC FINGER DOMAIN-CONTAINING ZINC FINGER PROTEIN 442 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HUMAN|HGNC=8713|UniProtKB=Q9Y5F9 Q9Y5F9 PCDHGB6 PTHR24028:SF66 CADHERIN-87A PROTOCADHERIN GAMMA-B6 cell adhesion#GO:0007155;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 cell adhesion molecule#PC00069;cadherin#PC00057 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HUMAN|HGNC=11023|UniProtKB=Q9Y2D2 Q9Y2D2 SLC35A3 PTHR10231:SF36 NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER UDP-N-ACETYLGLUCOSAMINE TRANSPORTER transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;nucleotide-sugar transmembrane transporter activity#GO:0005338;carbohydrate derivative transmembrane transporter activity#GO:1901505;UDP-galactose transmembrane transporter activity#GO:0005459;nucleobase-containing compound transmembrane transporter activity#GO:0015932;organophosphate ester transmembrane transporter activity#GO:0015605 transport#GO:0006810;cellular process#GO:0009987;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139 transporter#PC00227 HUMAN|HGNC=9260|UniProtKB=Q9Y3C6 Q9Y3C6 PPIL1 PTHR45625:SF7 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 1 catalytic activity#GO:0003824;peptidyl-prolyl cis-trans isomerase activity#GO:0003755;isomerase activity#GO:0016853;cis-trans isomerase activity#GO:0016859;catalytic activity, acting on a protein#GO:0140096 mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;mRNA splicing, via spliceosome#GO:0000398;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 spliceosomal complex#GO:0005681;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;nuclear protein-containing complex#GO:0140513;catalytic step 2 spliceosome#GO:0071013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HUMAN|HGNC=5922|UniProtKB=A0A075B6J1 A0A075B6J1 IGLV5-37 PTHR23267:SF325 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN LAMBDA VARIABLE 5-37-RELATED immune system process#GO:0002376;immune response#GO:0006955;response to stimulus#GO:0050896 protein-containing complex#GO:0032991 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=35164|UniProtKB=Q8TAD7 Q8TAD7 OCC1 PTHR38502:SF1 OVEREXPRESSED IN COLON CARCINOMA 1 PROTEIN OVEREXPRESSED IN COLON CARCINOMA 1 PROTEIN HUMAN|HGNC=1390|UniProtKB=Q13936 Q13936 CACNA1C PTHR45628:SF10 VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1 VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C calcium channel activity#GO:0005262;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261;channel activity#GO:0015267;voltage-gated calcium channel activity#GO:0005245;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832 calcium ion transmembrane transport#GO:0070588;calcium ion import#GO:0070509;import across plasma membrane#GO:0098739;metal ion transport#GO:0030001;inorganic ion import across plasma membrane#GO:0099587;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;import into cell#GO:0098657;calcium ion transmembrane import into cytosol#GO:0097553;establishment of localization#GO:0051234;inorganic cation import across plasma membrane#GO:0098659;calcium ion transport#GO:0006816 transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;cation channel complex#GO:0034703;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane protein complex#GO:0098796;membrane#GO:0016020;voltage-gated calcium channel complex#GO:0005891;calcium channel complex#GO:0034704;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797 voltage-gated ion channel#PC00241 Nicotine pharmacodynamics pathway#P06587>CACNA#P06600;Oxytocin receptor mediated signaling pathway#P04391>Ca2+ channel#P04535;Beta2 adrenergic receptor signaling pathway#P04378>Ca2+ channel#P04445;5HT2 type receptor mediated signaling pathway#P04374>Ca2+ channel#P04411;Alzheimer disease-amyloid secretase pathway#P00003>L-type calcium channels#P00082;Beta1 adrenergic receptor signaling pathway#P04377>Ca2+ channel#P04438;Gonadotropin-releasing hormone receptor pathway#P06664>L-type Ca2+#P06812;Nicotinic acetylcholine receptor signaling pathway#P00044>Ca2+ channel#P01096 HUMAN|HGNC=6423|UniProtKB=P08779 P08779 KRT16 PTHR23239:SF105 INTERMEDIATE FILAMENT KERATIN, TYPE I CYTOSKELETAL 16 structural molecule activity#GO:0005198 cellular process#GO:0009987;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;skin development#GO:0043588;tissue development#GO:0009888;epithelial cell differentiation#GO:0030855;epidermal cell differentiation#GO:0009913;epithelium development#GO:0060429;developmental process#GO:0032502;epidermis development#GO:0008544;morphogenesis of an epithelium#GO:0002009;animal organ development#GO:0048513;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;intermediate filament cytoskeleton organization#GO:0045104;cell differentiation#GO:0030154;intermediate filament organization#GO:0045109;animal gross anatomical part developmental process#GO:0160108;keratinocyte differentiation#GO:0030216;intermediate filament-based process#GO:0045103;supramolecular fiber organization#GO:0097435;anatomical structure development#GO:0048856;tissue morphogenesis#GO:0048729 organelle#GO:0043226;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;intermediate filament#GO:0005882;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 intermediate filament#PC00129 HUMAN|HGNC=10009|UniProtKB=Q02161 Q02161 RHD PTHR11730:SF43 AMMONIUM TRANSPORTER BLOOD GROUP RH(D) POLYPEPTIDE channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 homeostatic process#GO:0042592;nitrogen compound transport#GO:0071705;cellular process#GO:0009987;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;chemical homeostasis#GO:0048878;inorganic ion homeostasis#GO:0098771;transport#GO:0006810 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227;primary active transporter#PC00068 HUMAN|HGNC=29437|UniProtKB=Q9HBJ8 Q9HBJ8 CLTRN PTHR46884:SF1 COLLECTRIN COLLECTRIN EGF receptor signaling pathway#P00018>Ras#P00552 HUMAN|HGNC=53451|UniProtKB=A0A087WWA1 A0A087WWA1 P3R3URF PTHR10155:SF27 PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT PIK3R3 UPSTREAM OPEN READING FRAME PROTEIN biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to chemical#GO:0042221;response to cytokine#GO:0034097;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;response to peptide#GO:1901652;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;cytokine-mediated signaling pathway#GO:0019221 kinase modulator#PC00140 HUMAN|HGNC=8124|UniProtKB=Q02218 Q02218 OGDH PTHR23152:SF7 2-OXOGLUTARATE DEHYDROGENASE 2-OXOGLUTARATE DEHYDROGENASE COMPLEX COMPONENT E1 oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the aldehyde or oxo group of donors#GO:0016903 primary metabolic process#GO:0044238;tricarboxylic acid cycle#GO:0006099;cellular process#GO:0009987;metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091;energy derivation by oxidation of organic compounds#GO:0015980;cellular respiration#GO:0045333;aerobic respiration#GO:0009060 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;oxidoreductase complex#GO:1990204;cytosol#GO:0005829;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle#GO:0043229 metabolite interconversion enzyme#PC00262;dehydrogenase#PC00092;oxidoreductase#PC00176 TCA cycle#P00051>alphaketoglutarate Dehydrogenase#P01269 HUMAN|HGNC=10823|UniProtKB=O75368 O75368 SH3BGRL PTHR12232:SF5 SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN ADAPTER SH3BGRL ubiquitin-like ligase-substrate adaptor activity#GO:1990756;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;enzyme-substrate adaptor activity#GO:0140767;protein-RNA adaptor activity#GO:0140517 regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;positive regulation of biosynthetic process#GO:0009891;protein metabolic process#GO:0019538;positive regulation of translation#GO:0045727;biological regulation#GO:0065007;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of cellular process#GO:0048522;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;ubiquitin-dependent protein catabolic process#GO:0006511;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;post-transcriptional regulation of gene expression#GO:0010608;regulation of biological process#GO:0050789;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;protein catabolic process#GO:0030163;regulation of translational initiation#GO:0006446;modification-dependent macromolecule catabolic process#GO:0043632;positive regulation of protein metabolic process#GO:0051247;positive regulation of macromolecule metabolic process#GO:0010604;proteasomal protein catabolic process#GO:0010498;regulation of protein metabolic process#GO:0051246;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 HUMAN|HGNC=816|UniProtKB=Q16720 Q16720 ATP2B3 PTHR24093:SF284 CATION TRANSPORTING ATPASE PLASMA MEMBRANE CALCIUM-TRANSPORTING ATPASE 3 monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;ATP-dependent activity#GO:0140657;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATPase-coupled transmembrane transporter activity#GO:0042626;monoatomic ion transmembrane transporter activity#GO:0015075;P-type ion transporter activity#GO:0015662;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873;primary active transmembrane transporter activity#GO:0015399;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 regulation of cytosolic calcium ion concentration#GO:0051480;monoatomic ion homeostasis#GO:0050801;intracellular monoatomic ion homeostasis#GO:0006873;homeostatic process#GO:0042592;intracellular monoatomic cation homeostasis#GO:0030003;inorganic ion homeostasis#GO:0098771;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;calcium ion homeostasis#GO:0055074;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 primary active transporter#PC00068 HUMAN|HGNC=9370|UniProtKB=P49643 P49643 PRIM2 PTHR10537:SF3 DNA PRIMASE LARGE SUBUNIT DNA PRIMASE LARGE SUBUNIT DNA-templated DNA replication#GO:0006261;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;DNA replication#GO:0006260;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;DNA metabolic process#GO:0006259;DNA replication initiation#GO:0006270;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234;DNA polymerase complex#GO:0042575;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;membrane-enclosed lumen#GO:0031974;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;nuclear replication fork#GO:0043596;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;protein-DNA complex#GO:0032993;nucleoplasm#GO:0005654;replication fork#GO:0005657;nuclear DNA-directed RNA polymerase complex#GO:0055029;replisome#GO:0030894;chromosome#GO:0005694;organelle lumen#GO:0043233 primase#PC00189 DNA replication#P00017>Primase#P00528 HUMAN|HGNC=38686|UniProtKB=P0CJ87 P0CJ87 DUX4L4 PTHR46123:SF3 MIX-TYPE HOMEOBOX GENE 1-RELATED DOUBLE HOMEOBOX PROTEIN 1-RELATED sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=4827|UniProtKB=P68871 P68871 HBB PTHR11442:SF42 HEMOGLOBIN FAMILY MEMBER HEMOGLOBIN SUBUNIT BETA protein binding#GO:0005515;tetrapyrrole binding#GO:0046906;molecular carrier activity#GO:0140104;binding#GO:0005488;heme binding#GO:0020037 cellular developmental process#GO:0048869;establishment of localization#GO:0051234;multicellular organismal-level homeostasis#GO:0048871;developmental process#GO:0032502;transport#GO:0006810;multicellular organismal process#GO:0032501;hemopoiesis#GO:0030097;cellular process#GO:0009987;localization#GO:0051179;erythrocyte differentiation#GO:0030218;anatomical structure development#GO:0048856;immune system process#GO:0002376;homeostasis of number of cells#GO:0048872;cell differentiation#GO:0030154;myeloid cell differentiation#GO:0030099;homeostatic process#GO:0042592;cell development#GO:0048468 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytosol#GO:0005829 transfer/carrier protein#PC00219;globin#PC00107 HUMAN|HGNC=20389|UniProtKB=Q9HD89 Q9HD89 RETN PTHR21101:SF11 RESISTIN RESISTIN receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677;hormone activity#GO:0005179 response to oxygen-containing compound#GO:1901700;developmental process#GO:0032502;cellular developmental process#GO:0048869;response to nitrogen compound#GO:1901698;response to endogenous stimulus#GO:0009719;fat cell differentiation#GO:0045444;response to hormone#GO:0009725;cellular process#GO:0009987;response to insulin#GO:0032868;response to chemical#GO:0042221;cell differentiation#GO:0030154;response to stimulus#GO:0050896;response to peptide hormone#GO:0043434 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=15968|UniProtKB=Q8TB36 Q8TB36 GDAP1 PTHR44188:SF3 GDAP1, ISOFORM A GANGLIOSIDE-INDUCED DIFFERENTIATION-ASSOCIATED PROTEIN 1 cellular component organization or biogenesis#GO:0071840;organelle fission#GO:0048285;organelle fusion#GO:0048284;mitochondrial fission#GO:0000266;mitochondrion organization#GO:0007005;mitochondrial fusion#GO:0008053;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987 mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;membrane#GO:0016020;cytoplasm#GO:0005737;organelle outer membrane#GO:0031968;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;mitochondrial outer membrane#GO:0005741;mitochondrion#GO:0005739;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;outer membrane#GO:0019867;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=1243|UniProtKB=Q07021 Q07021 C1QBP PTHR10826:SF1 COMPLEMENT COMPONENT 1 COMPLEMENT COMPONENT 1 Q SUBCOMPONENT-BINDING PROTEIN, MITOCHONDRIAL protein-RNA adaptor activity#GO:0140517;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 RNA catabolic process#GO:0006401;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;RNA metabolic process#GO:0016070;mitochondrial RNA metabolic process#GO:0000959;macromolecule metabolic process#GO:0043170;nucleic acid catabolic process#GO:0141188;cellular process#GO:0009987;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;nucleobase-containing compound catabolic process#GO:0034655;nucleobase-containing compound metabolic process#GO:0006139;catabolic process#GO:0009056 mitochondrion#GO:0005739;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 complement component#PC00078;defense/immunity protein#PC00090 HUMAN|HGNC=16261|UniProtKB=Q8IVM8 Q8IVM8 SLC22A9 PTHR24064:SF592 SOLUTE CARRIER FAMILY 22 MEMBER ORGANIC ANION TRANSPORTER 7 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;cellular process#GO:0009987;transport#GO:0006810 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 secondary carrier transporter#PC00258 HUMAN|HGNC=31357|UniProtKB=Q86UW8 Q86UW8 HAPLN4 PTHR22804:SF11 AGGRECAN/VERSICAN PROTEOGLYCAN HYALURONAN AND PROTEOGLYCAN LINK PROTEIN 4 system development#GO:0048731;skeletal system development#GO:0001501;multicellular organism development#GO:0007275;anatomical structure development#GO:0048856;developmental process#GO:0032502;animal gross anatomical part developmental process#GO:0160108;nervous system development#GO:0007399;central nervous system development#GO:0007417;multicellular organismal process#GO:0032501 plasma membrane#GO:0005886;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cell junction#GO:0030054;extracellular region#GO:0005576 extracellular matrix protein#PC00102;extracellular matrix glycoprotein#PC00100 HUMAN|HGNC=30555|UniProtKB=Q96D03 Q96D03 DDIT4L PTHR12478:SF17 DNA-DAMAGE-INDUCIBLE TRANSCRIPT 4 PROTEIN DDIT4 DNA DAMAGE-INDUCIBLE TRANSCRIPT 4-LIKE PROTEIN regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;programmed cell death#GO:0012501;regulation of biological process#GO:0050789;cellular process#GO:0009987;apoptotic process#GO:0006915;cell death#GO:0008219;regulation of TOR signaling#GO:0032006;regulation of intracellular signal transduction#GO:1902531;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051 HUMAN|HGNC=6605|UniProtKB=Q8NHL6 Q8NHL6 LILRB1 PTHR11738:SF165 MHC CLASS I NK CELL RECEPTOR LEUKOCYTE IMMUNOGLOBULIN-LIKE RECEPTOR SUBFAMILY A MEMBER 1-RELATED transmembrane signaling receptor activity#GO:0004888;immune receptor activity#GO:0140375;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 response to peptide#GO:1901652;cell communication#GO:0007154;regulation of immune response#GO:0050776;cytokine-mediated signaling pathway#GO:0019221;signaling#GO:0023052;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;immune response-regulating signaling pathway#GO:0002764;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;response to cytokine#GO:0034097;response to chemical#GO:0042221;cellular process#GO:0009987;signal transduction#GO:0007165 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=18469|UniProtKB=Q9UIJ5 Q9UIJ5 ZDHHC2 PTHR22883:SF207 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE ZDHHC2 catalytic activity, acting on a protein#GO:0140096;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;palmitoyltransferase activity#GO:0016409;acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824 synapse assembly#GO:0007416;cell junction organization#GO:0034330;protein targeting#GO:0006605;cell junction assembly#GO:0034329;cellular component organization#GO:0016043;localization#GO:0051179;anatomical structure development#GO:0048856;cellular localization#GO:0051641;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;synapse organization#GO:0050808;localization within membrane#GO:0051668;cellular component assembly#GO:0022607;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;establishment of protein localization to membrane#GO:0090150;cellular component biogenesis#GO:0044085;establishment of protein localization#GO:0045184;cellular process#GO:0009987;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;protein targeting to membrane#GO:0006612;developmental process#GO:0032502 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 protein modifying enzyme#PC00260 HUMAN|HGNC=29198|UniProtKB=Q96AT1 Q96AT1 KIAA1143 PTHR31195:SF2 GEO02494P1 GEO02494P1 HUMAN|HGNC=25516|UniProtKB=Q8TER5 Q8TER5 ARHGEF40 PTHR45845:SF5 RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR-RELATED RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 40 guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=24616|UniProtKB=Q8N1G1 Q8N1G1 REXO1 PTHR12801:SF62 RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED RNA EXONUCLEASE 1 HOMOLOG catalytic activity#GO:0003824;exonuclease activity#GO:0004527;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;nuclease activity#GO:0004518 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 exoribonuclease#PC00099;RNA metabolism protein#PC00031 HUMAN|HGNC=15806|UniProtKB=Q9HCZ1 Q9HCZ1 ZNF334 PTHR24377:SF116 IP01015P-RELATED ZINC FINGER PROTEIN 334 cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=317|UniProtKB=P02771 P02771 AFP PTHR11385:SF7 SERUM ALBUMIN-RELATED ALPHA-FETOPROTEIN binding#GO:0005488;small molecule binding#GO:0036094 response to nutrient levels#GO:0031667;response to stimulus#GO:0050896 transfer/carrier protein#PC00219 HUMAN|HGNC=26717|UniProtKB=Q96AQ9 Q96AQ9 FAM131C PTHR15736:SF2 PROTEIN FAM131B-RELATED PROTEIN FAM131C HUMAN|HGNC=19216|UniProtKB=Q99954 Q99954 SMR3A PTHR14179:SF11 SMR1-RELATED SUBMAXILLARY GLAND ANDROGEN-REGULATED PROTEIN 3A molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;peptidase regulator activity#GO:0061134;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866;enzyme inhibitor activity#GO:0004857 regulation of system process#GO:0044057;regulation of biological process#GO:0050789;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191;protein-binding activity modulator#PC00095 HUMAN|HGNC=30414|UniProtKB=Q9BVK8 Q9BVK8 TMEM147 PTHR12869:SF0 SMALL SEVEN TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN BOS COMPLEX SUBUNIT TMEM147 HUMAN|HGNC=30075|UniProtKB=O15318 O15318 POLR3G PTHR15367:SF3 DNA-DIRECTED RNA POLYMERASE III DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC7 cell population proliferation#GO:0008283;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;transferase complex, transferring phosphorus-containing groups#GO:0061695;RNA polymerase III complex#GO:0005666;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535 DNA-directed RNA polymerase#PC00019 HUMAN|HGNC=33999|UniProtKB=P0DN26 P0DN26 PPIAL4F PTHR11071:SF466 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A-LIKE 4C-RELATED cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 chaperone#PC00072 HUMAN|HGNC=7889|UniProtKB=Q9Y5S8 Q9Y5S8 NOX1 PTHR11972:SF71 NADPH OXIDASE NADPH OXIDASE 1 catalytic activity#GO:0003824;oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor#GO:0050664;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on NAD(P)H#GO:0016651 response to stimulus#GO:0050896;superoxide metabolic process#GO:0006801;defense response#GO:0006952;metabolic process#GO:0008152;reactive oxygen species metabolic process#GO:0072593;response to stress#GO:0006950;cellular process#GO:0009987 catalytic complex#GO:1902494;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane protein complex#GO:0098796;oxidoreductase complex#GO:1990204;membrane#GO:0016020;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 oxidase#PC00175;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=18683|UniProtKB=P38919 P38919 EIF4A3 PTHR47958:SF26 ATP-DEPENDENT RNA HELICASE DBP3 EUKARYOTIC INITIATION FACTOR 4A-III RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;ATP-dependent activity#GO:0140657;helicase activity#GO:0004386;catalytic activity, acting on RNA#GO:0140098;isomerase activity#GO:0016853;catalytic activity#GO:0003824;RNA helicase activity#GO:0003724;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;macromolecular conformation isomerase activity#GO:0120543 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397 intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;catalytic step 2 spliceosome#GO:0071013;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;spliceosomal complex#GO:0005681;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013 RNA helicase#PC00032 HUMAN|HGNC=15774|UniProtKB=Q8WWY6 Q8WWY6 MBD3L1 PTHR12396:SF1 METHYL-CPG BINDING PROTEIN, MBD METHYL-CPG-BINDING DOMAIN PROTEIN 3-LIKE 1 negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cellular component assembly#GO:0022607;heterochromatin organization#GO:0070828;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;cellular component organization or biogenesis#GO:0071840;DNA methylation-dependent constitutive heterochromatin formation#GO:0006346;negative regulation of gene expression, epigenetic#GO:0045814;constitutive heterochromatin formation#GO:0140719;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of primary metabolic process#GO:0080090;epigenetic regulation of gene expression#GO:0040029;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;chromatin organization#GO:0006325;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;negative regulation of cellular process#GO:0048523;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;heterochromatin formation#GO:0031507;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of DNA-templated transcription#GO:0006355;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=24558|UniProtKB=Q68BL8 Q68BL8 OLFML2B PTHR23192:SF37 OLFACTOMEDIN-RELATED OLFACTOMEDIN-LIKE PROTEIN 2B cell communication#GO:0007154;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 structural protein#PC00211 HUMAN|HGNC=38707|UniProtKB=A0A087WUV0 A0A087WUV0 ZNF892 PTHR24377:SF956 IP01015P-RELATED ZINC FINGER PROTEIN 892 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=16105|UniProtKB=Q9NX31 Q9NX31 OSER1 PTHR31383:SF2 OXIDATIVE STRESS-RESPONSE SERINE-RICH PROTEIN 1 OXIDATIVE STRESS-RESPONSIVE SERINE-RICH PROTEIN 1 HUMAN|HGNC=1788|UniProtKB=P42772 P42772 CDKN2B PTHR24201:SF8 ANK_REP_REGION DOMAIN-CONTAINING PROTEIN CYCLIN-DEPENDENT KINASE 4 INHIBITOR B enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538;enzyme inhibitor activity#GO:0004857;kinase inhibitor activity#GO:0019210;cyclin-dependent protein kinase regulator activity#GO:0019914;protein kinase regulator activity#GO:0019887;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;protein kinase inhibitor activity#GO:0004860;cyclin-dependent protein serine/threonine kinase inhibitor activity#GO:0004861 regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of cell cycle process#GO:0010564;regulation of cell cycle#GO:0051726;regulation of cell cycle G1/S phase transition#GO:1902806;negative regulation of cell population proliferation#GO:0008285;negative regulation of biological process#GO:0048519;regulation of cell cycle phase transition#GO:1901987;regulation of mitotic cell cycle#GO:0007346;regulation of biological process#GO:0050789;regulation of cell population proliferation#GO:0042127;regulation of mitotic cell cycle phase transition#GO:1901990;negative regulation of cellular process#GO:0048523;regulation of G1/S transition of mitotic cell cycle#GO:2000045 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634 protein-binding activity modulator#PC00095;kinase inhibitor#PC00139 p53 pathway#P00059>ARF#G01574 HUMAN|HGNC=79|UniProtKB=P16442 P16442 ABO PTHR10462:SF29 GLYCOSYLTRANSFERASE-RELATED HISTO-BLOOD GROUP ABO SYSTEM TRANSFERASE UDP-glycosyltransferase activity#GO:0008194;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757;acetylgalactosaminyltransferase activity#GO:0008376;hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;catalytic activity#GO:0003824 vesicle#GO:0031982;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111 HUMAN|HGNC=17185|UniProtKB=Q8WXI3 Q8WXI3 ASB10 PTHR24123:SF136 ANKYRIN REPEAT-CONTAINING ANKYRIN REPEAT AND SOCS BOX PROTEIN 10 enzyme regulator activity#GO:0030234;phosphatase regulator activity#GO:0019208;molecular function regulator activity#GO:0098772 catalytic complex#GO:1902494;protein serine/threonine phosphatase complex#GO:0008287;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 scaffold/adaptor protein#PC00226 HUMAN|HGNC=7104|UniProtKB=Q99797 Q99797 MIPEP PTHR11804:SF79 PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED MITOCHONDRIAL INTERMEDIATE PEPTIDASE metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 mitochondrion#GO:0005739;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 protease#PC00190;metalloprotease#PC00153 HUMAN|HGNC=26039|UniProtKB=Q9NX04 Q9NX04 AIRIM PTHR16234:SF5 SIMILAR TO HYPOTHETICAL PROTEIN FLJ20508 AFG2-INTERACTING RIBOSOME MATURATION FACTOR cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HUMAN|HGNC=8001|UniProtKB=P48552 P48552 NRIP1 PTHR15088:SF0 NUCLEAR FACTOR RIP140 NUCLEAR RECEPTOR-INTERACTING PROTEIN 1 transcription coregulator activity#GO:0003712;nuclear receptor binding#GO:0016922;transcription corepressor activity#GO:0003714;transcription factor binding#GO:0008134;nuclear estrogen receptor binding#GO:0030331;transcription coactivator activity#GO:0003713;binding#GO:0005488;transcription regulator activity#GO:0140110;protein binding#GO:0005515;RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629;DNA-binding transcription factor binding#GO:0140297 regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;negative regulation of metabolic process#GO:0009892;circadian regulation of gene expression#GO:0032922;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of DNA-templated transcription#GO:0045892;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;circadian rhythm#GO:0007623;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;cellular response to chemical stimulus#GO:0070887;response to oxygen-containing compound#GO:1901700;rhythmic process#GO:0048511;response to lipid#GO:0033993;cellular response to lipid#GO:0071396;positive regulation of macromolecule metabolic process#GO:0010604;response to chemical#GO:0042221;response to estradiol#GO:0032355;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;cellular response to oxygen-containing compound#GO:1901701;positive regulation of transcription by RNA polymerase II#GO:0045944;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;cellular response to stimulus#GO:0051716;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=3649|UniProtKB=Q9UK73 Q9UK73 FEM1B PTHR24173:SF78 ANKYRIN REPEAT CONTAINING PROTEIN FEM-1 HOMOLOG B enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;ubiquitin ligase complex#GO:0000151;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;transferase complex#GO:1990234;catalytic complex#GO:1902494 scaffold/adaptor protein#PC00226 HUMAN|HGNC=25587|UniProtKB=Q9NVA4 Q9NVA4 TMEM184C PTHR23423:SF10 ORGANIC SOLUTE TRANSPORTER-RELATED TRANSMEMBRANE PROTEIN 184C transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 cellular anatomical structure#GO:0110165;membrane#GO:0016020 transporter#PC00227 HUMAN|HGNC=13172|UniProtKB=O43309 O43309 ZSCAN12 PTHR23226:SF68 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 12 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=7881|UniProtKB=P46531 P46531 NOTCH1 PTHR45836:SF12 SLIT HOMOLOG NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1 response to stimulus#GO:0050896;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell morphogenesis#GO:0000902;signaling#GO:0023052;cell development#GO:0048468;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;neuron development#GO:0048666;axonogenesis#GO:0007409;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;neuron projection development#GO:0031175;signal transduction#GO:0007165;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cell projection morphogenesis#GO:0048858;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell surface receptor signaling pathway#GO:0007166;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;anatomical structure development#GO:0048856;system development#GO:0048731;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;axon guidance#GO:0007411;axon development#GO:0061564;Notch signaling pathway#GO:0007219;cellular developmental process#GO:0048869;neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812 membrane#GO:0016020;signaling receptor complex#GO:0043235;cell periphery#GO:0071944;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886 Angiogenesis#P00005>Notch#P00255;Notch signaling pathway#P00045>Notch#P01099;Notch signaling pathway#P00045>NIct#P01119;Alzheimer disease-presenilin pathway#P00004>Notch N-terminal fragment#P00171;Notch signaling pathway#P00045>NIcs#P01120;Notch signaling pathway#P00045>Ntm#P01114;Alzheimer disease-presenilin pathway#P00004>Notch#P00176;Alzheimer disease-presenilin pathway#P00004>Notch fragment#P00154;Alzheimer disease-presenilin pathway#P00004>Notch C-terminal fragment#P00120;Alzheimer disease-presenilin pathway#P00004>Notch extracellular fragment#P00179;Notch signaling pathway#P00045>Next#P01103;Alzheimer disease-presenilin pathway#P00004>Notch transmembrane fragment#P00135;Alzheimer disease-presenilin pathway#P00004>NICD#P00122 HUMAN|HGNC=28385|UniProtKB=Q502W6 Q502W6 VWA3B PTHR46785:SF1 VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 3B VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 3B HUMAN|HGNC=1506|UniProtKB=P51878 P51878 CASP5 PTHR10454:SF243 CASPASE CASPASE-5 hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;cysteine-type endopeptidase activity#GO:0004197;endopeptidase activity#GO:0004175;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234 positive regulation of inflammatory response#GO:0050729;regulation of response to stress#GO:0080134;positive regulation of neuron apoptotic process#GO:0043525;regulation of response to stimulus#GO:0048583;regulation of apoptotic process#GO:0042981;positive regulation of defense response#GO:0031349;positive regulation of response to external stimulus#GO:0032103;positive regulation of apoptotic process#GO:0043065;defense response#GO:0006952;response to stress#GO:0006950;regulation of neuron apoptotic process#GO:0043523;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of response to external stimulus#GO:0032101;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of inflammatory response#GO:0050727;regulation of defense response#GO:0031347;inflammatory response#GO:0006954;programmed cell death#GO:0012501;regulation of programmed cell death#GO:0043067;cell death#GO:0008219;apoptotic process#GO:0006915;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;positive regulation of programmed cell death#GO:0043068;response to stimulus#GO:0050896 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;canonical inflammasome complex#GO:0061702;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 protease#PC00190;protein modifying enzyme#PC00260 HUMAN|HGNC=32311|UniProtKB=Q96T53 Q96T53 MBOAT4 PTHR13906:SF3 PORCUPINE MEMBRANE-BOUND GHRELIN O-ACYLTRANSFERASE MBOAT4 acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746 primary metabolic process#GO:0044238;metabolic process#GO:0008152;cellular process#GO:0009987;lipid metabolic process#GO:0006629;lipid modification#GO:0030258 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229 acetyltransferase#PC00038 HUMAN|HGNC=12569|UniProtKB=O95185 O95185 UNC5C PTHR12582:SF7 NETRIN RECEPTOR UNC5 NETRIN RECEPTOR UNC5C molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;anatomical structure development#GO:0048856;system development#GO:0048731;axonogenesis#GO:0007409;neuron development#GO:0048666;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell morphogenesis#GO:0000902;cell development#GO:0048468;developmental process#GO:0032502;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron projection morphogenesis#GO:0048812;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;neuron projection guidance#GO:0097485;cell projection morphogenesis#GO:0048858;neurogenesis#GO:0022008;neuron projection development#GO:0031175;axon development#GO:0061564;axon guidance#GO:0007411;cellular process#GO:0009987;multicellular organismal process#GO:0032501;cell morphogenesis involved in neuron differentiation#GO:0048667;plasma membrane bounded cell projection organization#GO:0120036;nervous system development#GO:0007399 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 Axon guidance mediated by netrin#P00009>UNC-5#P00356 HUMAN|HGNC=13023|UniProtKB=P17027 P17027 ZNF23 PTHR24377:SF180 IP01015P-RELATED ZINC FINGER PROTEIN 23 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700 regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=23297|UniProtKB=Q96SI1 Q96SI1 KCTD15 PTHR14499:SF27 POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD15 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714 negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 scaffold/adaptor protein#PC00226 HUMAN|HGNC=8591|UniProtKB=Q13177 Q13177 PAK2 PTHR48015:SF22 SERINE/THREONINE-PROTEIN KINASE TAO SERINE_THREONINE-PROTEIN KINASE PAK 2 protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096 response to nutrient levels#GO:0031667;response to stress#GO:0006950;signal transduction#GO:0007165;cellular process#GO:0009987;cell migration#GO:0016477;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;cellular response to starvation#GO:0009267;regulation of MAPK cascade#GO:0043408;cellular response to nutrient levels#GO:0031669;regulation of response to stimulus#GO:0048583;response to starvation#GO:0042594;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell motility#GO:0048870;signaling#GO:0023052;regulation of cell communication#GO:0010646;regulation of intracellular signal transduction#GO:1902531;cellular response to stress#GO:0033554;regulation of signaling#GO:0023051;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 Ras Pathway#P04393>PAK#P04553;Cytoskeletal regulation by Rho GTPase#P00016>PAK#P00517;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PAK#P00837;T cell activation#P00053>PAK#P01319;Angiogenesis#P00005>PAK#P00249 HUMAN|HGNC=1512|UniProtKB=P31415 P31415 CASQ1 PTHR10033:SF14 CALSEQUESTRIN CALSEQUESTRIN-1 metal ion binding#GO:0046872;cation binding#GO:0043169;molecular sequestering activity#GO:0140313;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;calcium ion binding#GO:0005509 regulation of monoatomic ion transport#GO:0043269;regulation of calcium ion transport#GO:0051924;biological regulation#GO:0065007;regulation of multicellular organismal process#GO:0051239;intracellular signaling cassette#GO:0141124;signal transduction#GO:0007165;regulation of monoatomic ion transmembrane transport#GO:0034765;cellular process#GO:0009987;regulation of localization#GO:0032879;regulation of transport#GO:0051049;calcium-mediated signaling#GO:0019722;regulation of release of sequestered calcium ion into cytosol#GO:0051279;regulation of system process#GO:0044057;regulation of monoatomic cation transmembrane transport#GO:1904062;response to stimulus#GO:0050896;regulation of metal ion transport#GO:0010959;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of muscle system process#GO:0090257;regulation of transmembrane transport#GO:0034762;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of muscle contraction#GO:0006937 intracellular organelle lumen#GO:0070013;sarcoplasm#GO:0016528;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;myofibril#GO:0030016;membrane-bounded organelle#GO:0043227;supramolecular fiber#GO:0099512;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;I band#GO:0031674;endoplasmic reticulum#GO:0005783;sarcomere#GO:0030017;membraneless organelle#GO:0043228;endoplasmic reticulum lumen#GO:0005788;membrane-enclosed lumen#GO:0031974;contractile muscle fiber#GO:0043292;sarcoplasmic reticulum#GO:0016529;Z disc#GO:0030018;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;endomembrane system#GO:0012505;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737 calcium-binding protein#PC00060 HUMAN|HGNC=16767|UniProtKB=Q8TCU5 Q8TCU5 GRIN3A PTHR18966:SF397 IONOTROPIC GLUTAMATE RECEPTOR GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3A gated channel activity#GO:0022836;transmembrane signaling receptor activity#GO:0004888;voltage-gated monoatomic ion channel activity#GO:0005244;voltage-gated channel activity#GO:0022832;transporter activity#GO:0005215;neurotransmitter receptor activity#GO:0030594;amino acid transmembrane transporter activity#GO:0015171;signaling receptor activity#GO:0038023;monoatomic ion channel activity#GO:0005216;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated monoatomic ion channel activity#GO:0015276;carboxylic acid transmembrane transporter activity#GO:0046943;channel activity#GO:0015267;molecular transducer activity#GO:0060089;transmembrane transporter activity#GO:0022857;ligand-gated channel activity#GO:0022834;glutamate receptor activity#GO:0008066;passive transmembrane transporter activity#GO:0022803;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;dicarboxylic acid transmembrane transporter activity#GO:0005310 synaptic signaling#GO:0099536;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of trans-synaptic signaling#GO:0099177;biological regulation#GO:0065007;synaptic transmission, glutamatergic#GO:0035249;cell-cell signaling#GO:0007267;cell surface receptor signaling pathway#GO:0007166;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;modulation of chemical synaptic transmission#GO:0050804;signaling#GO:0023052;regulation of cell communication#GO:0010646;trans-synaptic signaling#GO:0099537;regulation of signaling#GO:0023051;cell communication#GO:0007154;glutamate receptor signaling pathway#GO:0007215 organelle#GO:0043226;asymmetric synapse#GO:0032279;synapse#GO:0045202;cellular anatomical structure#GO:0110165;postsynapse#GO:0098794;postsynaptic density membrane#GO:0098839;postsynaptic specialization membrane#GO:0099634;postsynaptic membrane#GO:0045211;postsynaptic density#GO:0014069;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;neuron to neuron synapse#GO:0098984;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;cell junction#GO:0030054;synaptic membrane#GO:0097060 transmembrane signal receptor#PC00197 Ionotropic glutamate receptor pathway#P00037>NR3#P01009;Metabotropic glutamate receptor group III pathway#P00039>NMDA#P01039;Huntington disease#P00029>NMDA receptor#P00778;Ionotropic glutamate receptor pathway#P00037>NMDA#P01024;Metabotropic glutamate receptor group I pathway#P00041>NMDA#P01060;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>NMDA#P01071 HUMAN|HGNC=929|UniProtKB=Q9UBX8 Q9UBX8 B4GALT6 PTHR19300:SF47 BETA-1,4-GALACTOSYLTRANSFERASE BETA-1,4-GALACTOSYLTRANSFERASE 6 hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;catalytic activity#GO:0003824;galactosyltransferase activity#GO:0008378;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757 lipid metabolic process#GO:0006629;glycosphingolipid biosynthetic process#GO:0006688;sphingolipid biosynthetic process#GO:0030148;metabolic process#GO:0008152;sphingolipid metabolic process#GO:0006665;carbohydrate derivative biosynthetic process#GO:1901137;glycolipid biosynthetic process#GO:0009247;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;glycolipid metabolic process#GO:0006664;lipid biosynthetic process#GO:0008610;liposaccharide metabolic process#GO:1903509 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 metabolite interconversion enzyme#PC00262;glycosyltransferase#PC00111 HUMAN|HGNC=29146|UniProtKB=A2VDJ0 A2VDJ0 TMEM131L PTHR22050:SF2 RW1 PROTEIN HOMOLOG TRANSMEMBRANE PROTEIN 131-LIKE metabolic process#GO:0008152;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of canonical Wnt signaling pathway#GO:0060828;cellular process#GO:0009987;negative regulation of response to stimulus#GO:0048585;negative regulation of Wnt signaling pathway#GO:0030178;biosynthetic process#GO:0009058;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;negative regulation of canonical Wnt signaling pathway#GO:0090090;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of Wnt signaling pathway#GO:0030111;regulation of cell communication#GO:0010646 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HUMAN|HGNC=13315|UniProtKB=Q9BY41 Q9BY41 HDAC8 PTHR10625:SF14 HISTONE DEACETYLASE HDAC1-RELATED HISTONE DEACETYLASE 8 histone modifying activity#GO:0140993;deacetylase activity#GO:0019213;catalytic activity, acting on a protein#GO:0140096;deacylase activity#GO:0160215;catalytic activity#GO:0003824;histone deacetylase activity#GO:0004407 regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;heterochromatin formation#GO:0031507;cellular component assembly#GO:0022607;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;chromatin organization#GO:0006325;heterochromatin organization#GO:0070828;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;regulation of macromolecule biosynthetic process#GO:0010556;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;negative regulation of gene expression, epigenetic#GO:0045814;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523 protein-containing complex#GO:0032991;nucleus#GO:0005634;histone deacetylase complex#GO:0000118;membrane-enclosed lumen#GO:0031974;nuclear protein-containing complex#GO:0140513;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 Wnt signaling pathway#P00057>Histone deacetylase#P01472 HUMAN|HGNC=21707|UniProtKB=Q9BU79 Q9BU79 TMEM243 PTHR28603:SF1 TRANSMEMBRANE PROTEIN 243 TRANSMEMBRANE PROTEIN 243 HUMAN|HGNC=4624|UniProtKB=P48637 P48637 GSS PTHR11130:SF0 GLUTATHIONE SYNTHETASE GLUTATHIONE SYNTHETASE ligase activity, forming carbon-nitrogen bonds#GO:0016879;catalytic activity#GO:0003824;ligase activity#GO:0016874 peptide metabolic process#GO:0006518;biosynthetic process#GO:0009058;metabolic process#GO:0008152;sulfur compound metabolic process#GO:0006790;modified amino acid metabolic process#GO:0006575;glutathione metabolic process#GO:0006749;cellular process#GO:0009987 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 ligase#PC00142 HUMAN|HGNC=6237|UniProtKB=Q9NSA2 Q9NSA2 KCND1 PTHR11537:SF174 VOLTAGE-GATED POTASSIUM CHANNEL A-TYPE VOLTAGE-GATED POTASSIUM CHANNEL KCND1 potassium channel activity#GO:0005267;outward rectifier potassium channel activity#GO:0015271;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873 monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;action potential#GO:0001508;metal ion transport#GO:0030001;transport#GO:0006810;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;cellular process#GO:0009987;potassium ion transport#GO:0006813;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220 synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;neuronal cell body#GO:0043025;neuron spine#GO:0044309;plasma membrane bounded cell projection#GO:0120025;membrane protein complex#GO:0098796;postsynapse#GO:0098794;cell body#GO:0044297;plasma membrane protein complex#GO:0098797;dendritic spine#GO:0043197;transmembrane transporter complex#GO:1902495;postsynaptic membrane#GO:0045211;dendrite#GO:0030425;dendritic tree#GO:0097447;plasma membrane region#GO:0098590;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;cell junction#GO:0030054;transporter complex#GO:1990351;cation channel complex#GO:0034703;synaptic membrane#GO:0097060;voltage-gated potassium channel complex#GO:0008076 voltage-gated ion channel#PC00241;ion channel#PC00133 HUMAN|HGNC=29618|UniProtKB=Q6UXG2 Q6UXG2 ELAPOR1 PTHR22727:SF13 PROTEIN CBG13728 ENDOSOME_LYSOSOME-ASSOCIATED APOPTOSIS AND AUTOPHAGY REGULATOR 1 metabolic process#GO:0008152;autophagosome assembly#GO:0000045;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;autophagosome organization#GO:1905037;positive regulation of cellular process#GO:0048522;autophagy#GO:0006914;positive regulation of biological process#GO:0048518;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;macroautophagy#GO:0016236;biological regulation#GO:0065007;cellular component assembly#GO:0022607;positive regulation of cellular component organization#GO:0051130;organelle assembly#GO:0070925;process utilizing autophagic mechanism#GO:0061919;vacuole organization#GO:0007033;positive regulation of organelle organization#GO:0010638;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;catabolic process#GO:0009056 endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular vesicle#GO:0097708;lysosome#GO:0005764;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;lytic vacuole#GO:0000323;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;cell periphery#GO:0071944;late endosome#GO:0005770;endomembrane system#GO:0012505;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;vacuole#GO:0005773;plasma membrane#GO:0005886 HUMAN|HGNC=43972|UniProtKB=A0A3B3IT33 A0A3B3IT33 TRIM51G PTHR24103:SF649 E3 UBIQUITIN-PROTEIN LIGASE TRIM TRIPARTITE MOTIF-CONTAINING PROTEIN 51G aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746 response to external stimulus#GO:0009605;defense response#GO:0006952;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;innate immune response#GO:0045087;immune response#GO:0006955;defense response to symbiont#GO:0140546;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;response to other organism#GO:0051707;defense response to other organism#GO:0098542;immune system process#GO:0002376;regulation of biological process#GO:0050789;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=14429|UniProtKB=Q9Y5L5 Q9Y5L5 LENEP PTHR16968:SF2 LENS EPITHELIAL CELL PROTEIN LEP503 LENS EPITHELIAL CELL PROTEIN LEP503 HUMAN|HGNC=5183|UniProtKB=P25021 P25021 HRH2 PTHR24247:SF263 5-HYDROXYTRYPTAMINE RECEPTOR HISTAMINE H2 RECEPTOR neurotransmitter receptor activity#GO:0030594;transmembrane signaling receptor activity#GO:0004888;G protein-coupled amine receptor activity#GO:0008227;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023 signaling#GO:0023052;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;anterograde trans-synaptic signaling#GO:0098916;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;synaptic signaling#GO:0099536;cell communication#GO:0007154;trans-synaptic signaling#GO:0099537;G protein-coupled receptor signaling pathway#GO:0007186 dendritic tree#GO:0097447;dendrite#GO:0030425;cell periphery#GO:0071944;neuron projection#GO:0043005;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;cell projection#GO:0042995;somatodendritic compartment#GO:0036477;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GsPCR#P00720;Histamine H2 receptor mediated signaling pathway#P04386>H2#P04489 HUMAN|HGNC=2570|UniProtKB=P00167 P00167 CYB5A PTHR19359:SF160 CYTOCHROME B5 CYTOCHROME B5 tetrapyrrole binding#GO:0046906;heme binding#GO:0020037;binding#GO:0005488 endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175 oxidoreductase#PC00176 HUMAN|HGNC=25296|UniProtKB=Q8IYM0 Q8IYM0 FAM186B PTHR33590:SF3 GLUTENIN, HIGH MOLECULAR WEIGHT SUBUNIT PW212-RELATED PROTEIN PROTEIN FAM186B HUMAN|HGNC=8756|UniProtKB=Q99447 Q99447 PCYT2 PTHR45780:SF2 ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779 glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;organophosphate metabolic process#GO:0019637;phospholipid metabolic process#GO:0006644;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;phospholipid biosynthetic process#GO:0008654;glycerophospholipid metabolic process#GO:0006650;glycerolipid metabolic process#GO:0046486;lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474;metabolic process#GO:0008152;organophosphate biosynthetic process#GO:0090407 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 nucleotidyltransferase#PC00174;transferase#PC00220 HUMAN|HGNC=24358|UniProtKB=Q9H2G4 Q9H2G4 TSPYL2 PTHR11875:SF72 TESTIS-SPECIFIC Y-ENCODED PROTEIN TESTIS-SPECIFIC Y-ENCODED-LIKE PROTEIN 2 protein binding#GO:0005515;binding#GO:0005488;histone binding#GO:0042393;chromatin binding#GO:0003682 intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=3020|UniProtKB=P21728 P21728 DRD1 PTHR24248:SF139 ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR D(1A) DOPAMINE RECEPTOR signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;postsynaptic neurotransmitter receptor activity#GO:0098960;neurotransmitter receptor activity#GO:0030594 cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;response to oxygen-containing compound#GO:1901700;cell communication#GO:0007154;adrenergic receptor signaling pathway#GO:0071875;response to nitrogen compound#GO:1901698;G protein-coupled dopamine receptor signaling pathway#GO:0007212;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;cellular response to nitrogen compound#GO:1901699;response to chemical#GO:0042221;biological regulation#GO:0065007;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;Dopamine receptor mediated signaling pathway#P05912>D1/D5#P05948;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GoPCR#P00725 HUMAN|HGNC=18005|UniProtKB=Q96F15 Q96F15 GIMAP5 PTHR10903:SF69 GTPASE, IMAP FAMILY MEMBER-RELATED GTPASE IMAP FAMILY MEMBER 5 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111 small GTPase#PC00208 HUMAN|HGNC=23272|UniProtKB=Q5CZA5 Q5CZA5 ZNF805 PTHR24377:SF1042 IP01015P-RELATED ZINC FINGER PROTEIN 543-RELATED RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=6906|UniProtKB=P42679 P42679 MATK PTHR24418:SF399 TYROSINE-PROTEIN KINASE MEGAKARYOCYTE-ASSOCIATED TYROSINE-PROTEIN KINASE phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;non-membrane spanning protein tyrosine kinase activity#GO:0004715;catalytic activity, acting on a protein#GO:0140096;protein tyrosine kinase activity#GO:0004713;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 non-receptor tyrosine protein kinase#PC00168 HUMAN|HGNC=28349|UniProtKB=Q96E14 Q96E14 RMI2 PTHR33962:SF1 RECQ-MEDIATED GENOME INSTABILITY PROTEIN 2 RMI2 RECQ-MEDIATED GENOME INSTABILITY PROTEIN 2 cellular response to stimulus#GO:0051716;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of sister chromatid segregation#GO:0033045;regulation of cell cycle#GO:0051726;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;cellular process#GO:0009987;response to stress#GO:0006950;regulation of cell cycle process#GO:0010564;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;regulation of chromosome segregation#GO:0051983;DNA damage response#GO:0006974;DNA metabolic process#GO:0006259;regulation of chromosome organization#GO:0033044;DNA repair#GO:0006281;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170 ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232;nuclear body#GO:0016604;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membraneless organelle#GO:0043228;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear speck#GO:0016607;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 HUMAN|HGNC=49416|UniProtKB=H0YKK7 H0YKK7 GOLGA6L19 PTHR23143:SF19 TRICHOHYALIN-RELATED GOLGIN A6 FAMILY LIKE 10-RELATED actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=23619|UniProtKB=Q9UFN0 Q9UFN0 NIPSNAP3A PTHR21017:SF23 NIPSNAP-RELATED PROTEIN NIPSNAP HOMOLOG 3A protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 macroautophagy#GO:0016236;catabolic process#GO:0009056;cellular process#GO:0009987;autophagy#GO:0006914;process utilizing autophagic mechanism#GO:0061919;mitophagy#GO:0000423;autophagy of mitochondrion#GO:0000422;metabolic process#GO:0008152 mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=5550|UniProtKB=P23083 P23083 IGHV1-2 PTHR23266:SF322 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 1-2 antigen binding#GO:0003823;binding#GO:0005488 immune effector process#GO:0002252;immune system process#GO:0002376;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;immune response#GO:0006955;adaptive immune response#GO:0002250;response to stimulus#GO:0050896 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=12527|UniProtKB=Q16851 Q16851 UGP2 PTHR43511:SF4 FAMILY NOT NAMED UTP--GLUCOSE-1-PHOSPHATE URIDYLYLTRANSFERASE HUMAN|HGNC=1571|UniProtKB=P32239 P32239 CCKBR PTHR24243:SF45 G-PROTEIN COUPLED RECEPTOR GASTRIN_CHOLECYSTOKININ TYPE B RECEPTOR transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021 CCKR signaling map#P06959>CCK2R#P07042 HUMAN|HGNC=17228|UniProtKB=Q9Y620 Q9Y620 RAD54B PTHR45629:SF16 SNF2/RAD54 FAMILY MEMBER DNA REPAIR AND RECOMBINATION PROTEIN RAD54B catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;DNA translocase activity#GO:0015616;ATP-dependent activity#GO:0140657;catalytic activity, acting on DNA#GO:0140097;ATP-dependent activity, acting on DNA#GO:0008094 nucleobase-containing compound metabolic process#GO:0006139;macromolecule metabolic process#GO:0043170;meiotic nuclear division#GO:0140013;DNA repair#GO:0006281;DNA damage response#GO:0006974;reproductive process#GO:0022414;homologous recombination#GO:0035825;cell cycle#GO:0007049;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;reciprocal homologous recombination#GO:0140527;cellular response to stimulus#GO:0051716;organelle fission#GO:0048285;meiosis I cell cycle process#GO:0061982;recombinational repair#GO:0000725;sexual reproduction#GO:0019953;organelle organization#GO:0006996;response to stress#GO:0006950;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;double-strand break repair#GO:0006302;meiotic cell cycle#GO:0051321;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;DNA recombination#GO:0006310;response to stimulus#GO:0050896;meiotic cell cycle process#GO:1903046;cellular component organization#GO:0016043;meiosis I#GO:0007127;double-strand break repair via homologous recombination#GO:0000724;cell cycle process#GO:0022402;nuclear division#GO:0000280;cellular response to stress#GO:0033554;reciprocal meiotic recombination#GO:0007131 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 damaged DNA-binding protein#PC00086 HUMAN|HGNC=28719|UniProtKB=Q68CZ6 Q68CZ6 HAUS3 PTHR19378:SF7 GOLGIN- RELATED HAUS AUGMIN-LIKE COMPLEX SUBUNIT 3 microtubule-based process#GO:0007017;microtubule organizing center organization#GO:0031023;cellular component organization or biogenesis#GO:0071840;spindle organization#GO:0007051;chromosome segregation#GO:0007059;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;cellular process#GO:0009987;spindle assembly#GO:0051225;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;microtubule cytoskeleton organization#GO:0000226;organelle assembly#GO:0070925;cell cycle process#GO:0022402;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;cell cycle#GO:0007049 microtubule cytoskeleton#GO:0015630;HAUS complex#GO:0070652;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;microtubule associated complex#GO:0005875;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;mitotic spindle#GO:0072686;cytoskeleton#GO:0005856;spindle#GO:0005819;microtubule organizing center#GO:0005815;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=19761|UniProtKB=Q8WXA3 Q8WXA3 RUFY2 PTHR45956:SF3 RUN AND FYVE DOMAIN-CONTAINING PROTEIN 2-LIKE PROTEIN RUN AND FYVE DOMAIN-CONTAINING PROTEIN 2 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=33718|UniProtKB=Q8TD35 Q8TD35 LKAAEAR1 PTHR35665:SF1 PROTEIN LKAAEAR1 PROTEIN LKAAEAR1 HUMAN|HGNC=31252|UniProtKB=Q8NH04 Q8NH04 OR2T27 PTHR26453:SF78 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2T27-RELATED transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;sensory perception#GO:0007600;nervous system process#GO:0050877;system process#GO:0003008;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;detection of chemical stimulus#GO:0009593;response to stimulus#GO:0050896;response to chemical#GO:0042221;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=18185|UniProtKB=Q9UJM3 Q9UJM3 ERRFI1 PTHR14254:SF5 GENE 33 POLYPEPTIDE ERBB RECEPTOR FEEDBACK INHIBITOR 1 negative regulation of response to stimulus#GO:0048585;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;regulation of epidermal growth factor receptor signaling pathway#GO:0042058;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;negative regulation of macromolecule metabolic process#GO:0010605;regulation of protein modification process#GO:0031399;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;regulation of cell communication#GO:0010646;negative regulation of protein metabolic process#GO:0051248;negative regulation of biological process#GO:0048519;regulation of ERBB signaling pathway#GO:1901184;regulation of biological process#GO:0050789;negative regulation of cell communication#GO:0010648;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=7565|UniProtKB=P13349 P13349 MYF5 PTHR11534:SF3 MYOGENIC FACTOR MYOGENIC FACTOR 5 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of cell development#GO:0010720;regulation of multicellular organismal process#GO:0051239;striated muscle tissue development#GO:0014706;positive regulation of cell differentiation#GO:0045597;muscle organ development#GO:0007517;animal organ development#GO:0048513;regulation of biological process#GO:0050789;positive regulation of multicellular organismal process#GO:0051240;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;animal gross anatomical part developmental process#GO:0160108;skeletal muscle organ development#GO:0060538;positive regulation of cellular process#GO:0048522;skeletal muscle tissue development#GO:0007519;regulation of cell development#GO:0060284;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;tissue development#GO:0009888;developmental process#GO:0032502;positive regulation of developmental process#GO:0051094;regulation of cell differentiation#GO:0045595;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of developmental process#GO:0050793;regulation of macromolecule metabolic process#GO:0060255;muscle structure development#GO:0061061;regulation of cellular process#GO:0050794;muscle tissue development#GO:0060537;regulation of RNA metabolic process#GO:0051252;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular anatomical structure#GO:0005622;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=16463|UniProtKB=O75400 O75400 PRPF40A PTHR11864:SF20 PRE-MRNA-PROCESSING PROTEIN PRP40 PRE-MRNA-PROCESSING FACTOR 40 HOMOLOG A RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 nucleus#GO:0005634;small nuclear ribonucleoprotein complex#GO:0030532;U1 snRNP#GO:0005685;protein-containing complex#GO:0032991;nuclear protein-containing complex#GO:0140513;Sm-like protein family complex#GO:0120114;spliceosomal complex#GO:0005681;U2-type prespliceosome#GO:0071004;U2-type spliceosomal complex#GO:0005684;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;spliceosomal snRNP complex#GO:0097525 HUMAN|HGNC=1529|UniProtKB=P56539 P56539 CAV3 PTHR10844:SF16 CAVEOLIN CAVEOLIN-3 protein binding#GO:0005515;transmembrane transporter binding#GO:0044325;binding#GO:0005488 cellular process#GO:0009987;cellular component biogenesis#GO:0044085;monoatomic ion homeostasis#GO:0050801;membrane organization#GO:0061024;endomembrane system organization#GO:0010256;biological regulation#GO:0065007;cellular component assembly#GO:0022607;developmental process#GO:0032502;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;intracellular calcium ion homeostasis#GO:0006874;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;regulation of membrane potential#GO:0042391;membrane assembly#GO:0071709;regulation of cytosolic calcium ion concentration#GO:0051480;intracellular monoatomic ion homeostasis#GO:0006873;cellular component organization#GO:0016043;homeostatic process#GO:0042592;cell differentiation#GO:0030154;inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;regulation of biological quality#GO:0065008;plasma membrane organization#GO:0007009 cell periphery#GO:0071944;membrane raft#GO:0045121;membrane#GO:0016020;caveola#GO:0005901;plasma membrane#GO:0005886;cell-substrate junction#GO:0030055;focal adhesion#GO:0005925;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;membrane microdomain#GO:0098857;anchoring junction#GO:0070161;cell junction#GO:0030054;sarcolemma#GO:0042383;plasma membrane raft#GO:0044853 scaffold/adaptor protein#PC00226 HUMAN|HGNC=26934|UniProtKB=Q9Y3C1 Q9Y3C1 NOP16 PTHR13243:SF1 HSPC111 PROTEIN-RELATED NUCLEOLAR PROTEIN 16 cellular component organization or biogenesis#GO:0071840;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;ribosomal large subunit biogenesis#GO:0042273;cellular component biogenesis#GO:0044085;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974 HUMAN|HGNC=30422|UniProtKB=Q8TF72 Q8TF72 SHROOM3 PTHR15012:SF33 APICAL PROTEIN/SHROOM-RELATED PROTEIN SHROOM3 binding#GO:0005488;actin filament binding#GO:0051015;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;protein binding#GO:0005515;protein-containing complex binding#GO:0044877 actin filament-based process#GO:0030029;cellular component organization or biogenesis#GO:0071840;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;actin cytoskeleton organization#GO:0030036;cytoskeleton organization#GO:0007010 membrane#GO:0016020;cell-cell junction#GO:0005911;cell periphery#GO:0071944;plasma membrane region#GO:0098590;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;cortical actin cytoskeleton#GO:0030864;apical junction complex#GO:0043296;cytoskeleton#GO:0005856;apical part of cell#GO:0045177;cell junction#GO:0030054;membraneless organelle#GO:0043228;adherens junction#GO:0005912;actin cytoskeleton#GO:0015629;apical plasma membrane#GO:0016324;cortical cytoskeleton#GO:0030863;cell cortex#GO:0005938;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=19763|UniProtKB=Q8WXK4 Q8WXK4 ASB12 PTHR24120:SF8 GH07239P ANKYRIN REPEAT AND SOCS BOX PROTEIN 12 ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824 intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;transferase complex#GO:1990234 HUMAN|HGNC=16297|UniProtKB=Q9UBR1 Q9UBR1 UPB1 PTHR43674:SF17 NITRILASE C965.09-RELATED BETA-UREIDOPROPIONASE catalytic activity#GO:0003824;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810 oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;amino acid biosynthetic process#GO:0008652;small molecule biosynthetic process#GO:0044283;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;cellular process#GO:0009987;carboxylic acid biosynthetic process#GO:0046394;small molecule metabolic process#GO:0044281;biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520 hydrolase#PC00121;metabolite interconversion enzyme#PC00262 Pyrimidine Metabolism#P02771>Beta-Ureidopropionase#P03127 HUMAN|HGNC=18143|UniProtKB=Q86T65 Q86T65 DAAM2 PTHR45725:SF7 FORMIN HOMOLOGY 2 FAMILY MEMBER DISHEVELED-ASSOCIATED ACTIVATOR OF MORPHOGENESIS 2 positive regulation of response to stimulus#GO:0048584;positive regulation of Wnt signaling pathway#GO:0030177;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of canonical Wnt signaling pathway#GO:0060828;regulation of cell development#GO:0060284;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of canonical Wnt signaling pathway#GO:0090263;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of cell differentiation#GO:0045595;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of Wnt signaling pathway#GO:0030111;regulation of cell communication#GO:0010646;regulation of developmental process#GO:0050793;regulation of neurogenesis#GO:0050767;positive regulation of signal transduction#GO:0009967;negative regulation of biological process#GO:0048519;negative regulation of multicellular organismal process#GO:0051241;regulation of multicellular organismal development#GO:2000026;regulation of biological process#GO:0050789;regulation of nervous system development#GO:0051960;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051 HUMAN|HGNC=14130|UniProtKB=Q9BRR9 Q9BRR9 ARHGAP9 PTHR23176:SF103 RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN RHO GTPASE-ACTIVATING PROTEIN 9 GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;signaling#GO:0023052;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;membrane#GO:0016020;cell periphery#GO:0071944 GTPase-activating protein#PC00257 PDGF signaling pathway#P00047>Rho#P01174 HUMAN|HGNC=24309|UniProtKB=O95232 O95232 LUC7L3 PTHR12375:SF47 RNA-BINDING PROTEIN LUC7-RELATED LUC7-LIKE PROTEIN 3 mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;mRNA splice site recognition#GO:0006376;gene expression#GO:0010467;cellular component assembly#GO:0022607;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;cellular component biogenesis#GO:0044085;protein-containing complex organization#GO:0043933;protein-RNA complex organization#GO:0071826;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;ribonucleoprotein complex biogenesis#GO:0022613;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;mRNA splicing, via spliceosome#GO:0000398;protein-containing complex assembly#GO:0065003;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;nucleic acid metabolic process#GO:0090304;protein-RNA complex assembly#GO:0022618;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;spliceosomal complex assembly#GO:0000245;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375 intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;spliceosomal snRNP complex#GO:0097525;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;U2-type spliceosomal complex#GO:0005684;U2-type prespliceosome#GO:0071004;cellular anatomical structure#GO:0110165;organelle#GO:0043226;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;small nuclear ribonucleoprotein complex#GO:0030532;protein-containing complex#GO:0032991;U1 snRNP#GO:0005685 HUMAN|HGNC=9822|UniProtKB=O15315 O15315 RAD51B PTHR46456:SF2 DNA REPAIR PROTEIN RAD51 HOMOLOG 2 DNA REPAIR PROTEIN RAD51 HOMOLOG 2 four-way junction DNA binding#GO:0000400;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;ATP-dependent activity, acting on DNA#GO:0008094;single-stranded DNA binding#GO:0003697;ATP-dependent activity#GO:0140657;nucleic acid binding#GO:0003676;binding#GO:0005488;catalytic activity, acting on DNA#GO:0140097;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640 double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;DNA recombination#GO:0006310;DNA damage response#GO:0006974;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;response to stress#GO:0006950;cellular response to stress#GO:0033554;recombinational repair#GO:0000725;response to stimulus#GO:0050896;double-strand break repair via homologous recombination#GO:0000724;cellular response to stimulus#GO:0051716;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694;nucleus#GO:0005634;replication fork#GO:0005657 DNA metabolism protein#PC00009 HUMAN|Gene=ERVFC1|UniProtKB=P60507 P60507 ERVFC1 PTHR10424:SF73 VIRAL ENVELOPE PROTEIN ENDOGENOUS RETROVIRUS GROUP FC1 ENV POLYPROTEIN-RELATED syncytium formation by cell-cell fusion#GO:0000768;cellular developmental process#GO:0048869;anatomical structure development#GO:0048856;striated muscle cell differentiation#GO:0051146;cell-cell fusion#GO:0140253;animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502;cell differentiation#GO:0030154;muscle structure development#GO:0061061;myoblast fusion#GO:0007520;muscle cell differentiation#GO:0042692;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 viral or transposable element protein#PC00237 HUMAN|HGNC=1820|UniProtKB=P31997 P31997 CEACAM8 PTHR44337:SF1 CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 8 CELL ADHESION MOLECULE CEACAM8 heterophilic cell-cell adhesion#GO:0007157;cellular process#GO:0009987;cell adhesion#GO:0007155;cell-cell adhesion#GO:0098609;homophilic cell-cell adhesion#GO:0007156 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 cell adhesion molecule#PC00069;immunoglobulin superfamily cell adhesion molecule#PC00125 HUMAN|HGNC=20082|UniProtKB=Q8N8A6 Q8N8A6 DDX51 PTHR24031:SF68 RNA HELICASE ATP-DEPENDENT RNA HELICASE DDX51 RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;ribosome biogenesis#GO:0042254;ribosomal large subunit biogenesis#GO:0042273;nucleic acid biosynthetic process#GO:0141187;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;maturation of LSU-rRNA#GO:0000470;gene expression#GO:0010467;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974 RNA helicase#PC00032;RNA metabolism protein#PC00031 HUMAN|HGNC=16778|UniProtKB=Q9BYR8 Q9BYR8 KRTAP3-1 PTHR23260:SF3 KERATIN ASSOCIATED PROTEIN 3-3-RELATED KERATIN-ASSOCIATED PROTEIN 3-1 structural protein#PC00211 HUMAN|HGNC=14819|UniProtKB=Q8NGE0 Q8NGE0 OR10AD1 PTHR26453:SF215 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 10AD1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 detection of chemical stimulus#GO:0009593;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;response to chemical#GO:0042221;response to stimulus#GO:0050896;nervous system process#GO:0050877;sensory perception#GO:0007600;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;system process#GO:0003008 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=30623|UniProtKB=Q8WWL2 Q8WWL2 SPIRE2 PTHR21345:SF5 SPIRE PROTEIN SPIRE HOMOLOG 2 protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;microtubule binding#GO:0008017;binding#GO:0005488 organelle organization#GO:0006996;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;cytoskeleton organization#GO:0007010;meiotic cell cycle#GO:0051321;Golgi vesicle transport#GO:0048193;membrane invagination#GO:0010324;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;meiotic cell cycle process#GO:1903046;cellular component organization#GO:0016043;cell cycle process#GO:0022402;establishment of organelle localization#GO:0051656;gamete generation#GO:0007276;nuclear division#GO:0000280;cytokinesis#GO:0000910;cytokinetic process#GO:0032506;spindle localization#GO:0051653;cellular localization#GO:0051641;cytoskeleton-dependent cytokinesis#GO:0061640;establishment of spindle localization#GO:0051293;membrane organization#GO:0061024;intracellular transport#GO:0046907;transport#GO:0006810;establishment of localization#GO:0051234;meiotic nuclear division#GO:0140013;actin filament organization#GO:0007015;cell cycle#GO:0007049;cell division#GO:0051301;actin cytoskeleton organization#GO:0030036;reproductive process#GO:0022414;organelle localization#GO:0051640;actin filament-based process#GO:0030029;sexual reproduction#GO:0019953;microtubule cytoskeleton organization#GO:0000226;organelle fission#GO:0048285;localization#GO:0051179;multicellular organismal reproductive process#GO:0048609;supramolecular fiber organization#GO:0097435 vesicle#GO:0031982;cell cortex#GO:0005938;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cell periphery#GO:0071944;membrane#GO:0016020;vesicle membrane#GO:0012506;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;organelle membrane#GO:0031090 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=9316|UniProtKB=P48454 P48454 PPP3CC PTHR45673:SF2 SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED SERINE_THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT GAMMA ISOFORM hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;calmodulin binding#GO:0005516;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;binding#GO:0005488;protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721;protein binding#GO:0005515;hydrolase activity#GO:0016787 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;intracellular signaling cassette#GO:0141124;calcineurin-mediated signaling#GO:0097720;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;calcium-mediated signaling#GO:0019722 catalytic complex#GO:1902494;protein serine/threonine phosphatase complex#GO:0008287;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195 B cell activation#P00010>Calcineurin#P00386;Wnt signaling pathway#P00057>Calcineurin#P01446;T cell activation#P00053>Calcineurin#P01315 HUMAN|HGNC=4965|UniProtKB=P01893 P01893 HLA-H PTHR16675:SF256 MHC CLASS I-RELATED HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, ALPHA CHAIN H-RELATED binding#GO:0005488;signaling receptor binding#GO:0005102;peptide binding#GO:0042277;antigen binding#GO:0003823;protein binding#GO:0005515 regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;positive regulation of adaptive immune response#GO:0002821;response to stimulus#GO:0050896;regulation of leukocyte mediated immunity#GO:0002703;regulation of biological process#GO:0050789;antigen processing and presentation#GO:0019882;regulation of immune effector process#GO:0002697;positive regulation of lymphocyte mediated immunity#GO:0002708;regulation of leukocyte mediated cytotoxicity#GO:0001910;immune system process#GO:0002376;regulation of lymphocyte mediated immunity#GO:0002706;regulation of cell killing#GO:0031341;regulation of immune response#GO:0050776;positive regulation of response to stimulus#GO:0048584;positive regulation of immune effector process#GO:0002699;biological regulation#GO:0065007;positive regulation of immune system process#GO:0002684;immune response#GO:0006955;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of leukocyte mediated immunity#GO:0002705;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778 cell surface#GO:0009986;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;side of membrane#GO:0098552;external side of plasma membrane#GO:0009897;extracellular region#GO:0005576 major histocompatibility complex protein#PC00149;defense/immunity protein#PC00090 HUMAN|HGNC=18867|UniProtKB=A8MYU2 A8MYU2 KCNU1 PTHR10027:SF23 CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN POTASSIUM CHANNEL SUBFAMILY U MEMBER 1 monoatomic ion-gated channel activity#GO:0022839;calcium-activated potassium channel activity#GO:0015269;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261;ligand-gated monoatomic ion channel activity#GO:0015276;potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;calcium-activated cation channel activity#GO:0005227;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;monoatomic cation transmembrane transporter activity#GO:0008324 establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;transport#GO:0006810;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;cellular process#GO:0009987 plasma membrane#GO:0005886;synapse#GO:0045202;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;cell periphery#GO:0071944;membrane#GO:0016020;postsynapse#GO:0098794;cell junction#GO:0030054;synaptic membrane#GO:0097060;postsynaptic membrane#GO:0045211 transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=6600|UniProtKB=P49916 P49916 LIG3 PTHR45674:SF20 DNA LIGASE 1/3 FAMILY MEMBER DNA LIGASE 3 catalytic activity, acting on DNA#GO:0140097;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;ligase activity#GO:0016874 DNA-templated DNA replication#GO:0006261;cellular response to stress#GO:0033554;DNA strand elongation involved in DNA replication#GO:0006271;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;DNA replication#GO:0006260;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;response to stress#GO:0006950 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA ligase#PC00012;DNA metabolism protein#PC00009 HUMAN|HGNC=3272|UniProtKB=Q13347 Q13347 EIF3I PTHR19877:SF1 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I translation factor activity#GO:0180051;nucleic acid binding#GO:0003676;binding#GO:0005488;translation initiation factor activity#GO:0003743;RNA binding#GO:0003723 protein biosynthetic process#GO:0160307;gene expression#GO:0010467;cytoplasmic translation#GO:0002181;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cytoplasmic translational initiation#GO:0002183;metabolic process#GO:0008152;translation#GO:0006412;translational initiation#GO:0006413 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;eukaryotic translation initiation factor 3 complex#GO:0005852 translation initiation factor#PC00224;translation factor#PC00223 HUMAN|HGNC=43626|UniProtKB=A0A1W2PQ27 A0A1W2PQ27 SSU72L1 PTHR20383:SF10 RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE SSU72 LIKE PROTEIN 1-RELATED phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;DNA-templated transcription termination#GO:0006353;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;transcription by RNA polymerase II#GO:0006366;mRNA 3'-end processing#GO:0031124;metabolic process#GO:0008152;termination of RNA polymerase II transcription#GO:0006369;nucleobase-containing compound biosynthetic process#GO:0034654;RNA 3'-end processing#GO:0031123;macromolecule metabolic process#GO:0043170 intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;mRNA cleavage factor complex#GO:0005849;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;mRNA cleavage and polyadenylation specificity factor complex#GO:0005847 protein phosphatase#PC00195 HUMAN|HGNC=11799|UniProtKB=P10828 P10828 THRB PTHR24082:SF210 NUCLEAR HORMONE RECEPTOR THYROID HORMONE RECEPTOR BETA sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;molecular transducer activity#GO:0060089;nuclear receptor activity#GO:0004879;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023;transcription regulator activity#GO:0140110;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulatory region nucleic acid binding#GO:0001067 positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;negative regulation of DNA-templated transcription#GO:0045892;hormone-mediated signaling pathway#GO:0009755;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;cellular response to chemical stimulus#GO:0070887;cellular response to endogenous stimulus#GO:0071495;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;cell differentiation#GO:0030154;cellular response to hormone stimulus#GO:0032870;negative regulation of metabolic process#GO:0009892;signaling#GO:0023052;response to endogenous stimulus#GO:0009719;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;positive regulation of transcription by RNA polymerase II#GO:0045944;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;positive regulation of macromolecule metabolic process#GO:0010604;response to chemical#GO:0042221;negative regulation of macromolecule biosynthetic process#GO:0010558;response to hormone#GO:0009725;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;cell communication#GO:0007154;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;intracellular signal transduction#GO:0035556;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;intracellular receptor signaling pathway#GO:0030522;positive regulation of RNA metabolic process#GO:0051254;cellular response to stimulus#GO:0051716;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;nuclear receptor-mediated signaling pathway#GO:0141193;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522 nuclear protein-containing complex#GO:0140513;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634 C4 zinc finger nuclear receptor#PC00169 HUMAN|HGNC=5743|UniProtKB=A0A0C4DH67 A0A0C4DH67 IGKV1-8 PTHR23267:SF320 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN KAPPA VARIABLE 1-8-RELATED response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 protein-containing complex#GO:0032991 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=20207|UniProtKB=Q6Y288 Q6Y288 B3GLCT PTHR10811:SF110 FRINGE-RELATED BETA-1,3-GLUCOSYLTRANSFERASE acetylglucosaminyltransferase activity#GO:0008375;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;catalytic activity#GO:0003824 glycosyltransferase#PC00111;transferase#PC00220 HUMAN|HGNC=6091|UniProtKB=P06213 P06213 INSR PTHR24416:SF535 TYROSINE-PROTEIN KINASE RECEPTOR INSULIN RECEPTOR transmembrane signaling receptor activity#GO:0004888;transmembrane receptor protein tyrosine kinase activity#GO:0004714;molecular transducer activity#GO:0060089;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;transmembrane receptor protein kinase activity#GO:0019199;signaling receptor activity#GO:0038023 glucose homeostasis#GO:0042593;chemical homeostasis#GO:0048878;cell surface receptor signaling pathway#GO:0007166;regulation of MAPK cascade#GO:0043408;response to chemical#GO:0042221;cellular process#GO:0009987;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;positive regulation of biological process#GO:0048518;response to hormone#GO:0009725;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;insulin receptor signaling pathway#GO:0008286;response to oxygen-containing compound#GO:1901700;regulation of intracellular signal transduction#GO:1902531;cellular response to chemical stimulus#GO:0070887;signaling#GO:0023052;cellular response to hormone stimulus#GO:0032870;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051897;carbohydrate homeostasis#GO:0033500;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;positive regulation of MAPK cascade#GO:0043410;regulation of response to stimulus#GO:0048583;cellular response to insulin stimulus#GO:0032869;positive regulation of intracellular signal transduction#GO:1902533;response to peptide hormone#GO:0043434;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;cellular response to nitrogen compound#GO:1901699;positive regulation of response to stimulus#GO:0048584;positive regulation of cellular process#GO:0048522;regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051896;response to nitrogen compound#GO:1901698;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of cell communication#GO:0010646;cellular response to peptide hormone stimulus#GO:0071375;homeostatic process#GO:0042592;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;response to insulin#GO:0032868;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967 plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165;axon#GO:0030424;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695;neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;transferase complex#GO:1990234;signaling receptor complex#GO:0043235;protein kinase complex#GO:1902911 transmembrane signal receptor#PC00197 Gonadotropin-releasing hormone receptor pathway#P06664>IR#P06802;PI3 kinase pathway#P00048>IR#P01187;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>INSR IGF-R IRR#P00885;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>Insulin IGF#P00882;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>INSR IGF-R IRR#P00895 HUMAN|HGNC=25501|UniProtKB=Q9NW68 Q9NW68 BSDC1 PTHR16019:SF5 SYNAPSE-ASSOCIATED PROTEIN BSD DOMAIN-CONTAINING PROTEIN 1 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=13761|UniProtKB=Q9UBG7 Q9UBG7 RBPJL PTHR10665:SF2 RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS-LIKE PROTEIN sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 immunoglobulin fold transcription factor#PC00251;Rel homology transcription factor#PC00252 Alzheimer disease-presenilin pathway#P00004>CSL#P00158;Notch signaling pathway#P00045>Su(H)#P01101;Angiogenesis#P00005>CSL#P00233 HUMAN|HGNC=23271|UniProtKB=Q6MZT1 Q6MZT1 RGS7BP PTHR21029:SF12 R-SEVEN BINDING PROTEIN (R7BP) HOMOLOG REGULATOR OF G PROTEIN SIGNALING 7-BINDING PROTEIN cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cell junction#GO:0030054;intracellular organelle#GO:0043229;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;synapse#GO:0045202;neuron projection#GO:0043005;nucleus#GO:0005634;postsynapse#GO:0098794 HUMAN|HGNC=33734|UniProtKB=A0A0A6YYL3 A0A0A6YYL3 POTEB PTHR24118:SF65 POTE ANKYRIN DOMAIN POTE ANKYRIN DOMAIN FAMILY MEMBER B-RELATED transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714;transcription regulator activity#GO:0140110 regulation of non-canonical NF-kappaB signal transduction#GO:1901222;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583 membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 membrane traffic protein#PC00150 HUMAN|HGNC=24584|UniProtKB=Q5RIA9 Q5RIA9 ZNG1E PTHR13748:SF31 COBW-RELATED ZINC-REGULATED GTPASE METALLOPROTEIN ACTIVATOR 1A-RELATED molecular carrier activity#GO:0140104;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;transition metal ion binding#GO:0046914;metal ion binding#GO:0046872;cation binding#GO:0043169;zinc ion binding#GO:0008270 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=1078|UniProtKB=Q13873 Q13873 BMPR2 PTHR23255:SF63 TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-2 transforming growth factor beta receptor activity#GO:0005024;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;transmembrane receptor protein kinase activity#GO:0019199;signaling receptor activity#GO:0038023;catalytic activity, acting on a protein#GO:0140096;transmembrane signaling receptor activity#GO:0004888;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;molecular transducer activity#GO:0060089;transmembrane receptor protein serine/threonine kinase activity#GO:0004675;phosphotransferase activity, alcohol group as acceptor#GO:0016773 signal transduction#GO:0007165;cellular process#GO:0009987;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;developmental process#GO:0032502;response to BMP#GO:0071772;cellular response to BMP stimulus#GO:0071773;cell surface receptor signaling pathway#GO:0007166;multicellular organism development#GO:0007275;vasculature development#GO:0001944;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;BMP signaling pathway#GO:0030509;cellular response to stimulus#GO:0051716;blood vessel development#GO:0001568;circulatory system development#GO:0072359;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;response to growth factor#GO:0070848;regulation of cellular process#GO:0050794;signaling#GO:0023052;animal gross anatomical part developmental process#GO:0160108;cell communication#GO:0007154;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;system development#GO:0048731;cellular response to growth factor stimulus#GO:0071363 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane#GO:0016020;signaling receptor complex#GO:0043235;cell periphery#GO:0071944 serine/threonine protein kinase receptor#PC00205 TGF-beta signaling pathway#P00052>TGFbetareceptor II#P01277;TGF-beta signaling pathway#P00052>TGFbetareceptors#P01283;Gonadotropin-releasing hormone receptor pathway#P06664>BMPR-IA/IB/II#P06740 HUMAN|HGNC=24271|UniProtKB=Q9NTM9 Q9NTM9 CUTC PTHR12598:SF0 COPPER HOMEOSTASIS PROTEIN CUTC COPPER HOMEOSTASIS PROTEIN CUTC HOMOLOG metal ion binding#GO:0046872;cation binding#GO:0043169;small molecule binding#GO:0036094;binding#GO:0005488;copper ion binding#GO:0005507;ion binding#GO:0043167;transition metal ion binding#GO:0046914 primary active transporter#PC00068 HUMAN|HGNC=7027|UniProtKB=Q12866 Q12866 MERTK PTHR24416:SF257 TYROSINE-PROTEIN KINASE RECEPTOR TYROSINE-PROTEIN KINASE MER protein tyrosine kinase activity#GO:0004713;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;transmembrane receptor protein kinase activity#GO:0019199;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;transmembrane receptor protein tyrosine kinase activity#GO:0004714;molecular transducer activity#GO:0060089;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 animal gross anatomical part developmental process#GO:0160108;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;localization#GO:0051179;cell communication#GO:0007154;system development#GO:0048731;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;endocytosis#GO:0006897;cell motility#GO:0048870;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;phagocytosis#GO:0006909;transport#GO:0006810;cell surface receptor signaling pathway#GO:0007166;developmental process#GO:0032502;import into cell#GO:0098657;establishment of localization#GO:0051234;multicellular organism development#GO:0007275;cellular process#GO:0009987;signal transduction#GO:0007165;multicellular organismal process#GO:0032501;cell migration#GO:0016477;nervous system development#GO:0007399;biological regulation#GO:0065007 plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;signaling receptor complex#GO:0043235;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=2532|UniProtKB=P08311 P08311 CTSG PTHR24271:SF13 KALLIKREIN-RELATED CATHEPSIN G serine-type peptidase activity#GO:0008236;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 serine protease#PC00203 HUMAN|HGNC=19716|UniProtKB=Q2KHT4 Q2KHT4 GSG1 PTHR10671:SF43 EPITHELIAL MEMBRANE PROTEIN-RELATED GERM CELL-SPECIFIC GENE 1 PROTEIN intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cell periphery#GO:0071944;membrane#GO:0016020 cytoskeletal protein#PC00085 HUMAN|HGNC=26995|UniProtKB=Q0VGE8 Q0VGE8 ZNF816 PTHR24377:SF911 IP01015P-RELATED ZINC FINGER PROTEIN 816 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=4488|UniProtKB=Q8NGA4 Q8NGA4 GPR32P1 PTHR24225:SF27 CHEMOTACTIC RECEPTOR G PROTEIN-COUPLED RECEPTOR 32-RELATED signaling receptor activity#GO:0038023;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;immune receptor activity#GO:0140375;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528 regulation of biological process#GO:0050789;immune response-regulating signaling pathway#GO:0002764;cellular response to stimulus#GO:0051716;signaling#GO:0023052;immune response-activating cell surface receptor signaling pathway#GO:0002429;response to stimulus#GO:0050896;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of immune response#GO:0050776;phospholipase C-activating G protein-coupled receptor signaling pathway#GO:0007200;immune system process#GO:0002376;positive regulation of cytosolic calcium ion concentration#GO:0007204;G protein-coupled receptor signaling pathway#GO:0007186;regulation of biological quality#GO:0065008;cell communication#GO:0007154;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;signal transduction#GO:0007165;cellular process#GO:0009987;positive regulation of immune system process#GO:0002684;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;positive regulation of response to stimulus#GO:0048584;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166;immune response-activating signaling pathway#GO:0002757 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=17274|UniProtKB=Q14134 Q14134 TRIM29 PTHR25465:SF7 B-BOX DOMAIN CONTAINING TRIPARTITE MOTIF-CONTAINING PROTEIN 29 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=694|UniProtKB=P36405 P36405 ARL3 PTHR45697:SF4 ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATED ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 3 guanyl nucleotide binding#GO:0019001;ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265;small molecule binding#GO:0036094;anion binding#GO:0043168;binding#GO:0005488;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;nucleotide binding#GO:0000166;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555 cilium assembly#GO:0060271;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component assembly#GO:0022607;cell projection organization#GO:0030030;plasma membrane bounded cell projection organization#GO:0120036;plasma membrane bounded cell projection assembly#GO:0120031;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782 microtubule cytoskeleton#GO:0015630;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 HUMAN|HGNC=18153|UniProtKB=O14836 O14836 TNFRSF13B PTHR15511:SF2 TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 13B TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 13B signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897 transmembrane signal receptor#PC00197 HUMAN|HGNC=19358|UniProtKB=Q9BV10 Q9BV10 ALG12 PTHR22760:SF1 GLYCOSYLTRANSFERASE DOL-P-MAN:MAN(7)GLCNAC(2)-PP-DOL ALPHA-1,6-MANNOSYLTRANSFERASE hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740;mannosyltransferase activity#GO:0000030;glycosyltransferase activity#GO:0016757 protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487;glycoprotein biosynthetic process#GO:0009101;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229 glycosyltransferase#PC00111 HUMAN|HGNC=30967|UniProtKB=Q9BU70 Q9BU70 TRMO PTHR12818:SF0 TRNA (ADENINE(37)-N6)-METHYLTRANSFERASE TRNA (ADENINE(37)-N6)-METHYLTRANSFERASE catalytic activity, acting on a tRNA#GO:0140101;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;tRNA methyltransferase activity#GO:0008175;RNA methyltransferase activity#GO:0008173;catalytic activity, acting on RNA#GO:0140098;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity#GO:0016740;catalytic activity#GO:0003824 HUMAN|HGNC=3040|UniProtKB=P53805 P53805 RCAN1 PTHR10300:SF4 CALCIPRESSIN CALCIPRESSIN-1 phosphatase regulator activity#GO:0019208;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;protein phosphatase regulator activity#GO:0019888 cell communication#GO:0007154;calcium-mediated signaling#GO:0019722;intracellular signal transduction#GO:0035556;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;signaling#GO:0023052 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 intercellular signal molecule#PC00207 HUMAN|HGNC=19837|UniProtKB=Q7Z5M8 Q7Z5M8 ABHD12B PTHR12277:SF69 ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN PROTEIN ABHD12B glycerophospholipase activity#GO:0004620;lipase activity#GO:0016298;catalytic activity#GO:0003824;carboxylic ester hydrolase activity#GO:0052689;phospholipase activity#GO:0120569;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787 neutral lipid catabolic process#GO:0046461;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;acylglycerol metabolic process#GO:0006639;acylglycerol catabolic process#GO:0046464;neutral lipid metabolic process#GO:0006638;glycerophospholipid catabolic process#GO:0046475;lipid catabolic process#GO:0016042;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;glycerophospholipid metabolic process#GO:0006650;glycerolipid catabolic process#GO:0046503;organophosphate catabolic process#GO:0046434;modified amino acid metabolic process#GO:0006575;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phospholipid metabolic process#GO:0006644;catabolic process#GO:0009056;phospholipid catabolic process#GO:0009395;glycerolipid metabolic process#GO:0046486 membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090 serine protease#PC00203 HUMAN|HGNC=11795|UniProtKB=P40225 P40225 THPO PTHR10560:SF0 THROMBOPOIETIN THROMBOPOIETIN signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515 cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;response to chemokine#GO:1990868;regulation of ERK1 and ERK2 cascade#GO:0070372;response to chemical#GO:0042221;response to cytokine#GO:0034097;cell surface receptor signaling pathway#GO:0007166;regulation of MAPK cascade#GO:0043408;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;positive regulation of cell population proliferation#GO:0008284;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;G protein-coupled receptor signaling pathway#GO:0007186;response to peptide#GO:1901652;positive regulation of signaling#GO:0023056;positive regulation of cellular process#GO:0048522;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of MAPK cascade#GO:0043410;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;cellular response to chemokine#GO:1990869;regulation of cell communication#GO:0010646;positive regulation of ERK1 and ERK2 cascade#GO:0070374;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;cytokine-mediated signaling pathway#GO:0019221;regulation of cell population proliferation#GO:0042127;chemokine-mediated signaling pathway#GO:0070098;cell communication#GO:0007154 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=6583|UniProtKB=P41214 P41214 EIF2D PTHR12217:SF4 EUKARYOTIC TRANSLATION INITIATION FACTOR 2D EUKARYOTIC TRANSLATION INITIATION FACTOR 2D translation factor activity#GO:0180051;translation initiation factor activity#GO:0003743 cellular component assembly#GO:0022607;gene expression#GO:0010467;biosynthetic process#GO:0009058;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-RNA complex organization#GO:0071826;protein-containing complex organization#GO:0043933;metabolic process#GO:0008152;cytoplasmic translation#GO:0002181;protein biosynthetic process#GO:0160307;ribonucleoprotein complex biogenesis#GO:0022613;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;protein-containing complex assembly#GO:0065003;protein-RNA complex assembly#GO:0022618;protein metabolic process#GO:0019538;cytoplasmic translational initiation#GO:0002183;translational initiation#GO:0006413;translation#GO:0006412 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 translation initiation factor#PC00224 HUMAN|HGNC=29175|UniProtKB=Q8N5D0 Q8N5D0 WDTC1 PTHR15574:SF40 WD REPEAT DOMAIN-CONTAINING FAMILY WD AND TETRATRICOPEPTIDE REPEATS PROTEIN 1 regulation of lipid metabolic process#GO:0019216;negative regulation of cellular process#GO:0048523;regulation of biosynthetic process#GO:0009889;negative regulation of biological process#GO:0048519;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of lipid biosynthetic process#GO:0046890;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007 intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;ubiquitin ligase complex#GO:0000151;transferase complex#GO:1990234;catalytic complex#GO:1902494;Cul4-RING E3 ubiquitin ligase complex#GO:0080008;cullin-RING ubiquitin ligase complex#GO:0031461;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=9955|UniProtKB=Q04206 Q04206 RELA PTHR24169:SF1 NUCLEAR FACTOR NF-KAPPA-B PROTEIN TRANSCRIPTION FACTOR P65 cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 innate immune response#GO:0045087;regulation of biosynthetic process#GO:0009889;cellular response to molecule of bacterial origin#GO:0071219;defense response#GO:0006952;regulation of gene expression#GO:0010468;response to external stimulus#GO:0009605;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;canonical NF-kappaB signal transduction#GO:0007249;response to other organism#GO:0051707;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;immune response#GO:0006955;positive regulation of cellular process#GO:0048522;regulation of DNA-templated transcription#GO:0006355;cell communication#GO:0007154;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;intracellular signal transduction#GO:0035556;response to bacterium#GO:0009617;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;response to external biotic stimulus#GO:0043207;cellular response to biotic stimulus#GO:0071216;cellular response to stimulus#GO:0051716;response to lipopolysaccharide#GO:0032496;positive regulation of transcription by RNA polymerase II#GO:0045944;response to lipid#GO:0033993;defense response to other organism#GO:0098542;cellular response to lipid#GO:0071396;positive regulation of macromolecule metabolic process#GO:0010604;response to cytokine#GO:0034097;response to chemical#GO:0042221;intracellular signaling cassette#GO:0141124;cellular response to lipopolysaccharide#GO:0071222;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;defense response to symbiont#GO:0140546;non-canonical NF-kappaB signal transduction#GO:0038061;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;response to peptide#GO:1901652;immune system process#GO:0002376;cellular response to chemical stimulus#GO:0070887;response to oxygen-containing compound#GO:1901700;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;regulation of biological process#GO:0050789;response to molecule of bacterial origin#GO:0002237 nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218;Rel homology transcription factor#PC00252 Toll receptor signaling pathway#P00054>NFkappaB#P01354;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>NFkappaB#P00859;Apoptosis signaling pathway#P00006>NFkappaB#P00297;Gonadotropin-releasing hormone receptor pathway#P06664>p65#P06702 HUMAN|HGNC=15356|UniProtKB=Q8NH43 Q8NH43 OR4L1 PTHR48002:SF59 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 4L1 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=17377|UniProtKB=Q8N6M5 Q8N6M5 ALLC PTHR12045:SF3 ALLANTOICASE INACTIVE ALLANTOICASE-RELATED Allantoin degradation#P02725>Allantoate amidohydrolase#P02821 HUMAN|HGNC=23381|UniProtKB=Q9NPH6 Q9NPH6 OBP2B PTHR11430:SF129 LIPOCALIN ODORANT-BINDING PROTEIN 2A-RELATED cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 transfer/carrier protein#PC00219 HUMAN|HGNC=2860|UniProtKB=Q9UBM7 Q9UBM7 DHCR7 PTHR21257:SF57 DELTA(14)-STEROL REDUCTASE 7-DEHYDROCHOLESTEROL REDUCTASE oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;catalytic activity#GO:0003824 primary metabolic process#GO:0044238;secondary alcohol metabolic process#GO:1902652;small molecule metabolic process#GO:0044281;cholesterol metabolic process#GO:0008203;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;alcohol metabolic process#GO:0006066;metabolic process#GO:0008152;sterol metabolic process#GO:0016125;steroid biosynthetic process#GO:0006694;secondary alcohol biosynthetic process#GO:1902653;cellular process#GO:0009987;alcohol biosynthetic process#GO:0046165;sterol biosynthetic process#GO:0016126;biosynthetic process#GO:0009058;steroid metabolic process#GO:0008202;lipid biosynthetic process#GO:0008610;cholesterol biosynthetic process#GO:0006695 membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227 oxidoreductase#PC00176;reductase#PC00198 HUMAN|HGNC=4629|UniProtKB=O15217 O15217 GSTA4 PTHR11571:SF123 GLUTATHIONE S-TRANSFERASE GLUTATHIONE S-TRANSFERASE A4 transferase activity#GO:0016740;catalytic activity#GO:0003824;glutathione transferase activity#GO:0004364;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765 glutathione metabolic process#GO:0006749;metabolic process#GO:0008152;response to xenobiotic stimulus#GO:0009410;cellular response to chemical stimulus#GO:0070887;sulfur compound metabolic process#GO:0006790;modified amino acid metabolic process#GO:0006575;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;response to chemical#GO:0042221;xenobiotic metabolic process#GO:0006805;cellular response to xenobiotic stimulus#GO:0071466 transferase#PC00220 HUMAN|HGNC=8011|UniProtKB=P78357 P78357 CNTNAP1 PTHR15036:SF43 PIKACHURIN-LIKE PROTEIN CONTACTIN-ASSOCIATED PROTEIN 1 cell projection morphogenesis#GO:0048858;myelination#GO:0042552;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;nervous system development#GO:0007399;signal transduction#GO:0007165;cellular process#GO:0009987;neuron projection development#GO:0031175;neuron development#GO:0048666;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;signaling#GO:0023052;cell development#GO:0048468;cell differentiation#GO:0030154;cell projection organization#GO:0030030;response to stimulus#GO:0050896;cell morphogenesis#GO:0000902;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;multicellular organismal process#GO:0032501;system development#GO:0048731;cell communication#GO:0007154;anatomical structure development#GO:0048856;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716 plasma membrane#GO:0005886;cell junction#GO:0030054;cellular anatomical structure#GO:0110165;synapse#GO:0045202;cell periphery#GO:0071944;membrane#GO:0016020 cell adhesion molecule#PC00069 HUMAN|HGNC=2903|UniProtKB=P78352 P78352 DLG4 PTHR23119:SF33 DISCS LARGE DISKS LARGE HOMOLOG 4 structural constituent of synapse#GO:0098918;protein binding#GO:0005515;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;binding#GO:0005488;signaling receptor binding#GO:0005102;kinase binding#GO:0019900;structural molecule activity#GO:0005198 regulation of biological process#GO:0050789;cellular component organization#GO:0016043;protein localization to membrane#GO:0072657;signaling#GO:0023052;cell adhesion#GO:0007155;receptor clustering#GO:0043113;animal gross anatomical part developmental process#GO:0160108;establishment or maintenance of cell polarity#GO:0007163;regulation of biological quality#GO:0065008;cellular localization#GO:0051641;cellular process#GO:0009987;cell-cell adhesion#GO:0098609;synaptic signaling#GO:0099536;nervous system development#GO:0007399;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;protein localization to synapse#GO:0035418;chemical synaptic transmission#GO:0007268;postsynapse organization#GO:0099173;cell junction organization#GO:0034330;anterograde trans-synaptic signaling#GO:0098916;establishment or maintenance of bipolar cell polarity#GO:0061245;synapse organization#GO:0050808;localization within membrane#GO:0051668;trans-synaptic signaling#GO:0099537;establishment or maintenance of apical/basal cell polarity#GO:0035088;protein localization to cell junction#GO:1902414;system development#GO:0048731;anatomical structure development#GO:0048856;cell communication#GO:0007154;establishment or maintenance of epithelial cell apical/basal polarity#GO:0045197;localization#GO:0051179;macromolecule localization#GO:0033036;membrane organization#GO:0061024;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;developmental process#GO:0032502;regulation of postsynaptic membrane neurotransmitter receptor levels#GO:0099072;intracellular protein localization#GO:0008104 asymmetric synapse#GO:0032279;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;postsynapse#GO:0098794;postsynaptic density membrane#GO:0098839;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;postsynaptic density#GO:0014069;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;neuron to neuron synapse#GO:0098984;plasma membrane#GO:0005886;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;cell junction#GO:0030054;neuromuscular junction#GO:0031594;synaptic membrane#GO:0097060 scaffold/adaptor protein#PC00226 Huntington disease#P00029>PSD-95#P00789 HUMAN|HGNC=10260|UniProtKB=P51449 P51449 RORC PTHR45805:SF1 NUCLEAR HORMONE RECEPTOR HR3-RELATED NUCLEAR RECEPTOR ROR-GAMMA molecular transducer activity#GO:0060089;cis-regulatory region sequence-specific DNA binding#GO:0000987;nuclear receptor activity#GO:0004879;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;steroid binding#GO:0005496;transcription regulatory region nucleic acid binding#GO:0001067;lipid binding#GO:0008289;sterol binding#GO:0032934;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulator activity#GO:0140110;sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C4 zinc finger nuclear receptor#PC00169 Hypoxia response via HIF activation#P00030>TOR#P00817 HUMAN|HGNC=18370|UniProtKB=Q9H0U4 Q9H0U4 RAB1B PTHR24073:SF1096 DRAB5-RELATED RAS-RELATED PROTEIN RAB-1B pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111 establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;autophagosome assembly#GO:0000045;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;metabolic process#GO:0008152;transport#GO:0006810;intracellular protein transport#GO:0006886;cellular component assembly#GO:0022607;macroautophagy#GO:0016236;cellular component biogenesis#GO:0044085;macromolecule localization#GO:0033036;organelle organization#GO:0006996;autophagosome organization#GO:1905037;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;autophagy#GO:0006914;cellular localization#GO:0051641;localization#GO:0051179;process utilizing autophagic mechanism#GO:0061919;protein transport#GO:0015031;vacuole organization#GO:0007033;organelle assembly#GO:0070925;catabolic process#GO:0009056;cellular component organization#GO:0016043 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;neuronal cell body#GO:0043025;somatodendritic compartment#GO:0036477;cell body#GO:0044297;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 G-protein#PC00020;small GTPase#PC00208 HUMAN|HGNC=16934|UniProtKB=Q9BSK4 Q9BSK4 FEM1A PTHR24173:SF12 ANKYRIN REPEAT CONTAINING PROTEIN FEM-1 HOMOLOG A ubiquitin-like ligase-substrate adaptor activity#GO:1990756;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;enzyme-substrate adaptor activity#GO:0140767 protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;regulation of inflammatory response#GO:0050727;regulation of defense response#GO:0031347;catabolic process#GO:0009056;negative regulation of inflammatory response#GO:0050728;negative regulation of defense response#GO:0031348;negative regulation of biological process#GO:0048519;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;regulation of response to stress#GO:0080134;macromolecule catabolic process#GO:0009057;regulation of response to stimulus#GO:0048583;regulation of response to external stimulus#GO:0032101;negative regulation of response to stimulus#GO:0048585;biological regulation#GO:0065007;negative regulation of response to external stimulus#GO:0032102;proteasomal protein catabolic process#GO:0010498;cellular process#GO:0009987 catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991 scaffold/adaptor protein#PC00226 HUMAN|HGNC=13841|UniProtKB=Q86SQ4 Q86SQ4 ADGRG6 PTHR12011:SF290 ADHESION G-PROTEIN COUPLED RECEPTOR ADHESION G PROTEIN-COUPLED RECEPTOR G6 G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888;laminin binding#GO:0043236;extracellular matrix binding#GO:0050840;molecular transducer activity#GO:0060089;protein binding#GO:0005515 anatomical structure development#GO:0048856;cell communication#GO:0007154;system development#GO:0048731;cellular response to stimulus#GO:0051716;heart morphogenesis#GO:0003007;regulation of cellular process#GO:0050794;animal organ morphogenesis#GO:0009887;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;developmental process#GO:0032502;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;glial cell differentiation#GO:0010001;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;animal gross anatomical part developmental process#GO:0160108;G protein-coupled receptor signaling pathway#GO:0007186;peripheral nervous system development#GO:0007422;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;circulatory system development#GO:0072359;cell differentiation#GO:0030154;response to stimulus#GO:0050896;cell development#GO:0048468;signaling#GO:0023052;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;animal organ development#GO:0048513;multicellular organism development#GO:0007275;anatomical structure formation involved in morphogenesis#GO:0048646;myelination#GO:0042552;gliogenesis#GO:0042063;cellular process#GO:0009987;signal transduction#GO:0007165;heart development#GO:0007507;nervous system development#GO:0007399 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=2528|UniProtKB=P53634 P53634 CTSC PTHR12411:SF1058 CYSTEINE PROTEASE FAMILY C1-RELATED DIPEPTIDYL PEPTIDASE 1 catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;cysteine-type endopeptidase activity#GO:0004197;endopeptidase activity#GO:0004175;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824 catabolic process#GO:0009056;primary metabolic process#GO:0044238;cellular process#GO:0009987;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;protein catabolic process#GO:0030163 intracellular organelle#GO:0043229;extracellular region#GO:0005576;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;lytic vacuole#GO:0000323;lysosome#GO:0005764;vacuole#GO:0005773;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;cysteine protease#PC00081;protease#PC00190 HUMAN|HGNC=26118|UniProtKB=Q49MG5 Q49MG5 MAP9 PTHR14739:SF9 MICROTUBULE-ASSOCIATED PROTEIN 9 MICROTUBULE-ASSOCIATED PROTEIN 9 tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;microtubule binding#GO:0008017;protein binding#GO:0005515 spindle assembly#GO:0051225;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;regulation of cell cycle process#GO:0010564;chromosome segregation#GO:0007059;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;membraneless organelle assembly#GO:0140694;nuclear chromosome segregation#GO:0098813;sister chromatid segregation#GO:0000819;cellular component organization#GO:0016043;cell cycle process#GO:0022402;mitotic nuclear division#GO:0140014;regulation of biological process#GO:0050789;mitotic spindle organization#GO:0007052;regulation of cell cycle#GO:0051726;regulation of cytokinesis#GO:0032465;nuclear division#GO:0000280;mitotic sister chromatid segregation#GO:0000070;regulation of mitotic cytokinesis#GO:1902412;mitotic spindle assembly#GO:0090307;biological regulation#GO:0065007;spindle organization#GO:0007051;chromosome organization#GO:0051276;mitotic cell cycle process#GO:1903047;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cell cycle#GO:0007049;regulation of cellular process#GO:0050794;mitotic cell cycle#GO:0000278;regulation of cell division#GO:0051302;organelle assembly#GO:0070925;organelle fission#GO:0048285;microtubule cytoskeleton organization#GO:0000226 intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;spindle microtubule#GO:0005876;microtubule#GO:0005874;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasmic microtubule#GO:0005881;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cytoskeleton#GO:0005856;spindle#GO:0005819;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;microtubule cytoskeleton#GO:0015630 non-motor microtubule binding protein#PC00166;cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=13041|UniProtKB=Q8NDW4 Q8NDW4 ZNF248 PTHR24381:SF68 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 248 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=13031|UniProtKB=Q16600 Q16600 ZNF239 PTHR23226:SF189 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER PROTEIN 239 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=18865|UniProtKB=Q5JUK3 Q5JUK3 KCNT1 PTHR10027:SF14 CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN POTASSIUM CHANNEL SUBFAMILY T MEMBER 1 transporter activity#GO:0005215;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;monoatomic ion-gated channel activity#GO:0022839;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261;ligand-gated monoatomic ion channel activity#GO:0015276;outward rectifier potassium channel activity#GO:0015271;potassium channel activity#GO:0005267;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079 establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;transport#GO:0006810;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=2620|UniProtKB=P33260 P33260 CYP2C18 PTHR24300:SF429 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 2C18 binding#GO:0005488;tetrapyrrole binding#GO:0046906;catalytic activity#GO:0003824;monooxygenase activity#GO:0004497;heme binding#GO:0020037;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen#GO:0016712 response to chemical#GO:0042221;icosanoid metabolic process#GO:0006690;cellular response to xenobiotic stimulus#GO:0071466;long-chain fatty acid metabolic process#GO:0001676;cellular process#GO:0009987;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;unsaturated fatty acid metabolic process#GO:0033559;lipid metabolic process#GO:0006629;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;xenobiotic metabolic process#GO:0006805;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;arachidonate metabolic process#GO:0019369;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;response to xenobiotic stimulus#GO:0009410;oxoacid metabolic process#GO:0043436;olefinic compound metabolic process#GO:0120254 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 oxidoreductase#PC00176;oxygenase#PC00177 HUMAN|HGNC=15904|UniProtKB=Q9H8E8 Q9H8E8 KAT14 PTHR20916:SF26 CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;protein-lysine-acetyltransferase activity#GO:0061733;N-acetyltransferase activity#GO:0008080;protein N-acyltransferase activity#GO:0140186;histone modifying activity#GO:0140993;histone acetyltransferase activity#GO:0004402;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein N-acetyltransferase activity#GO:0034212;catalytic activity, acting on a protein#GO:0140096;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 HUMAN|HGNC=2326|UniProtKB=Q9UKF6 Q9UKF6 CPSF3 PTHR11203:SF11 CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 3 RNA nuclease activity#GO:0004540;endonuclease activity#GO:0004519;catalytic activity, acting on RNA#GO:0140098;RNA endonuclease activity#GO:0004521;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;RNA binding#GO:0003723;hydrolase activity#GO:0016787;nuclease activity#GO:0004518;5'-3' exonuclease activity#GO:0008409;exonuclease activity#GO:0004527;nucleic acid binding#GO:0003676;binding#GO:0005488 RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA 3'-end processing#GO:0031123;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;mRNA 3'-end processing#GO:0031124;metabolic process#GO:0008152;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;mRNA cleavage and polyadenylation specificity factor complex#GO:0005847;intracellular membrane-bounded organelle#GO:0043231;mRNA cleavage factor complex#GO:0005849;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634 RNA processing factor#PC00147 HUMAN|HGNC=19359|UniProtKB=Q5VWW1 Q5VWW1 C1QL3 PTHR22923:SF96 CEREBELLIN-RELATED COMPLEMENT C1Q-LIKE PROTEIN 3 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=16705|UniProtKB=Q5XG87 Q5XG87 TENT4A PTHR23092:SF24 POLY(A) RNA POLYMERASE TERMINAL NUCLEOTIDYLTRANSFERASE 4A transferase activity, transferring phosphorus-containing groups#GO:0016772;adenylyltransferase activity#GO:0070566;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;catabolic process#GO:0009056;RNA biosynthetic process#GO:0032774;modification-dependent macromolecule catabolic process#GO:0043632;RNA catabolic process#GO:0006401;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;nucleobase-containing compound catabolic process#GO:0034655;nucleic acid catabolic process#GO:0141188;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;RNA 3'-end processing#GO:0031123;macromolecule metabolic process#GO:0043170 membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;organelle lumen#GO:0043233;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 mRNA polyadenylation factor#PC00146 HUMAN|HGNC=29037|UniProtKB=O75038 O75038 PLCH2 PTHR10336:SF166 PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN 1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ETA-2 hydrolase activity#GO:0016787;lipase activity#GO:0016298;phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578;catalytic activity#GO:0003824;glycerophospholipase activity#GO:0004620;phospholipase activity#GO:0120569;hydrolase activity, acting on ester bonds#GO:0016788 regulation of biological process#GO:0050789;cellular process#GO:0009987;regulation of cellular process#GO:0050794;regulation of trans-synaptic signaling#GO:0099177;cell-cell signaling#GO:0007267;modulation of chemical synaptic transmission#GO:0050804;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;regulation of signaling#GO:0023051;cell communication#GO:0007154 lipase#PC00143;phospholipase#PC00186;metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HUMAN|HGNC=32394|UniProtKB=A8MU46 A8MU46 SMTNL1 PTHR23167:SF45 CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED SMOOTHELIN-LIKE PROTEIN 1 actin cytoskeleton organization#GO:0030036;cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;actin filament-based process#GO:0030029 scaffold/adaptor protein#PC00226 HUMAN|HGNC=6853|UniProtKB=Q99558 Q99558 MAP3K14 PTHR48016:SF9 MAP KINASE KINASE KINASE SSK2-RELATED-RELATED MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 14 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;signaling#GO:0023052;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154;MAPK cascade#GO:0000165;intracellular signal transduction#GO:0035556 non-receptor serine/threonine protein kinase#PC00167 Apoptosis signaling pathway#P00006>NIK#P00324;Gonadotropin-releasing hormone receptor pathway#P06664>MAP3Ks#P06834;CCKR signaling map#P06959>MAP3K14#P07063 HUMAN|HGNC=127|UniProtKB=P26436 P26436 ACRV1 PTHR17571:SF34 URINARY PROTEIN RUP /ACROSOMAL PROTEIN SP-10 ACROSOMAL PROTEIN SP-10 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;vesicle#GO:0031982 HUMAN|HGNC=17648|UniProtKB=Q9HBU9 Q9HBU9 POPDC2 PTHR12101:SF15 POPEYE DOMAIN CONTAINING PROTEIN POPEYE DOMAIN-CONTAINING PROTEIN 2 ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;small molecule binding#GO:0036094;anion binding#GO:0043168;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;ribonucleotide binding#GO:0032553;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;nucleotide binding#GO:0000166 striated muscle cell differentiation#GO:0051146;cellular developmental process#GO:0048869;regulation of membrane potential#GO:0042391;animal organ development#GO:0048513;multicellular organism development#GO:0007275;developmental process#GO:0032502;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;heart development#GO:0007507;cellular process#GO:0009987;cell-cell adhesion#GO:0098609;regulation of biological quality#GO:0065008;system development#GO:0048731;anatomical structure development#GO:0048856;cell adhesion#GO:0007155;animal gross anatomical part developmental process#GO:0160108;muscle structure development#GO:0061061;circulatory system development#GO:0072359;cell differentiation#GO:0030154;muscle cell differentiation#GO:0042692 cell-cell junction#GO:0005911;membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;bicellular tight junction#GO:0005923;plasma membrane#GO:0005886;apical junction complex#GO:0043296;tight junction#GO:0070160;sarcolemma#GO:0042383;cell junction#GO:0030054;anchoring junction#GO:0070161 HUMAN|HGNC=30701|UniProtKB=O75949 O75949 NALF2 PTHR15819:SF8 TRANSMEMBRANE PROTEIN FAM155 NALCN CHANNEL AUXILIARY FACTOR 2 transporter regulator activity#GO:0141108;molecular function regulator activity#GO:0098772;channel regulator activity#GO:0016247 inorganic ion import across plasma membrane#GO:0099587;import across plasma membrane#GO:0098739;cellular process#GO:0009987;inorganic cation import across plasma membrane#GO:0098659;establishment of localization#GO:0051234;import into cell#GO:0098657;transmembrane transport#GO:0055085;localization#GO:0051179;transport#GO:0006810 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 HUMAN|HGNC=11055|UniProtKB=P48029 P48029 SLC6A8 PTHR11616:SF96 SODIUM/CHLORIDE DEPENDENT TRANSPORTER SODIUM- AND CHLORIDE-DEPENDENT CREATINE TRANSPORTER 1 carboxylic acid transmembrane transporter activity#GO:0046943;amino acid:sodium symporter activity#GO:0005283;solute:sodium symporter activity#GO:0015370;transmembrane transporter activity#GO:0022857;chloride transmembrane transporter activity#GO:0015108;sodium ion transmembrane transporter activity#GO:0015081;active transmembrane transporter activity#GO:0022804;solute:monoatomic cation symporter activity#GO:0015294;symporter activity#GO:0015293;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;monoatomic anion transmembrane transporter activity#GO:0008509;secondary active transmembrane transporter activity#GO:0015291;amino acid transmembrane transporter activity#GO:0015171;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075 monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;sodium ion transport#GO:0006814;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;monoatomic ion transport#GO:0006811;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;amino acid transport#GO:0006865;transport#GO:0006810 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 primary active transporter#PC00068 Nicotinic acetylcholine receptor signaling pathway#P00044>CHT1#P01098;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>CHT1#P01084 HUMAN|HGNC=25459|UniProtKB=Q8N7H5 Q8N7H5 PAF1 PTHR23188:SF12 RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG chromatin binding#GO:0003682;enzyme binding#GO:0019899;RNA polymerase binding#GO:0070063;binding#GO:0005488;RNA polymerase core enzyme binding#GO:0043175;RNA polymerase II complex binding#GO:0000993;protein binding#GO:0005515 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;RNA polymerase II, holoenzyme#GO:0016591;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;transcription elongation factor complex#GO:0008023;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;transferase complex#GO:1990234;Cdc73/Paf1 complex#GO:0016593;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;membrane-enclosed lumen#GO:0031974;protein-containing complex#GO:0032991 HUMAN|HGNC=26661|UniProtKB=Q8IYW5 Q8IYW5 RNF168 PTHR23328:SF1 RING-TYPE DOMAIN-CONTAINING PROTEIN E3 UBIQUITIN-PROTEIN LIGASE RNF168 binding#GO:0005488;acyltransferase activity#GO:0016746;chromatin binding#GO:0003682;ubiquitin-like protein transferase activity#GO:0019787;protein-containing complex binding#GO:0044877;ubiquitin-protein transferase activity#GO:0004842;nucleosome binding#GO:0031491;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 macromolecule metabolic process#GO:0043170;double-strand break repair#GO:0006302;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139;response to stress#GO:0006950;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;site of double-strand break#GO:0035861;chromosome#GO:0005694;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;site of DNA damage#GO:0090734;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229 HUMAN|HGNC=3750|UniProtKB=Q13045 Q13045 FLII PTHR11977:SF142 VILLIN PROTEIN FLIGHTLESS-1 HOMOLOG lipid binding#GO:0008289;protein-containing complex binding#GO:0044877;phosphatidylinositol bisphosphate binding#GO:1902936;protein binding#GO:0005515;actin binding#GO:0003779;actin filament binding#GO:0051015;ion binding#GO:0043167;phosphatidylinositol-4,5-bisphosphate binding#GO:0005546;small molecule binding#GO:0036094;binding#GO:0005488;anion binding#GO:0043168;phosphatidylinositol phosphate binding#GO:1901981;cytoskeletal protein binding#GO:0008092;phospholipid binding#GO:0005543 regulation of actin filament organization#GO:0110053;regulation of actin filament polymerization#GO:0030833;negative regulation of protein depolymerization#GO:1901880;regulation of actin polymerization or depolymerization#GO:0008064;regulation of actin filament-based process#GO:0032970;developmental process#GO:0032502;cellular developmental process#GO:0048869;negative regulation of cellular component organization#GO:0051129;myofibril assembly#GO:0030239;regulation of supramolecular fiber organization#GO:1902903;actin cytoskeleton organization#GO:0030036;regulation of protein polymerization#GO:0032271;negative regulation of supramolecular fiber organization#GO:1902904;regulation of cytoskeleton organization#GO:0051493;organelle assembly#GO:0070925;actin filament capping#GO:0051693;negative regulation of protein-containing complex disassembly#GO:0043242;negative regulation of cytoskeleton organization#GO:0051494;supramolecular fiber organization#GO:0097435;regulation of protein-containing complex disassembly#GO:0043244;cellular component assembly#GO:0022607;regulation of actin cytoskeleton organization#GO:0032956;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;regulation of protein-containing complex assembly#GO:0043254;regulation of cellular component size#GO:0032535;cell differentiation#GO:0030154;actomyosin structure organization#GO:0031032;negative regulation of actin filament depolymerization#GO:0030835;actin polymerization or depolymerization#GO:0008154;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;regulation of protein depolymerization#GO:1901879;actin filament organization#GO:0007015;negative regulation of organelle organization#GO:0010639;muscle cell development#GO:0055001;muscle cell differentiation#GO:0042692;muscle structure development#GO:0061061;regulation of cellular process#GO:0050794;regulation of actin filament depolymerization#GO:0030834;cellular component assembly involved in morphogenesis#GO:0010927;actin filament-based process#GO:0030029;negative regulation of protein polymerization#GO:0032272;anatomical structure development#GO:0048856;negative regulation of protein-containing complex assembly#GO:0031333;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;regulation of anatomical structure size#GO:0090066;cellular anatomical entity morphogenesis#GO:0032989;cellular component organization or biogenesis#GO:0071840;anatomical structure formation involved in morphogenesis#GO:0048646;striated muscle cell differentiation#GO:0051146;negative regulation of biological process#GO:0048519;regulation of organelle organization#GO:0033043;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;regulation of cellular component organization#GO:0051128;regulation of cellular component biogenesis#GO:0044087;cell development#GO:0048468;negative regulation of actin filament polymerization#GO:0030837;animal gross anatomical part developmental process#GO:0160108;regulation of actin filament length#GO:0030832;striated muscle cell development#GO:0055002;regulation of biological quality#GO:0065008 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;nucleus#GO:0005634;actin cytoskeleton#GO:0015629;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 non-motor actin binding protein#PC00165;actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=9198|UniProtKB=P53803 P53803 POLR2K PTHR12056:SF4 DNA-DIRECTED RNA POLYMERASES I, II, AND III DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC4 catalytic activity, acting on RNA#GO:0140098;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;nucleotidyltransferase activity#GO:0016779 nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;RNA polymerase II, core complex#GO:0005665;nucleoplasm#GO:0005654;organelle#GO:0043226;RNA polymerase III complex#GO:0005666;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;RNA polymerase I complex#GO:0005736;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;RNA polymerase II, holoenzyme#GO:0016591;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 General transcription by RNA polymerase I#P00022>RNA Polymerase I Complex#P00652 HUMAN|HGNC=17162|UniProtKB=Q9Y4Y9 Q9Y4Y9 LSM5 PTHR20971:SF0 U6 SNRNA-ASSOCIATED PROTEIN U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM5 nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;spliceosomal snRNP complex#GO:0097525;Lsm2-8 complex#GO:0120115;spliceosomal tri-snRNP complex#GO:0097526;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;U4/U6 x U5 tri-snRNP complex#GO:0046540;nucleus#GO:0005634;small nuclear ribonucleoprotein complex#GO:0030532;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513;U6 snRNP#GO:0005688 RNA splicing factor#PC00148 HUMAN|HGNC=4943|UniProtKB=P01906 P01906 HLA-DQA2 PTHR19944:SF94 MHC CLASS II-RELATED HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DQ ALPHA 2 CHAIN antigen binding#GO:0003823;peptide binding#GO:0042277;binding#GO:0005488;protein-containing complex binding#GO:0044877 immune system process#GO:0002376;regulation of lymphocyte activation#GO:0051249;regulation of cell activation#GO:0050865;positive regulation of multicellular organismal process#GO:0051240;regulation of biological process#GO:0050789;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;regulation of leukocyte activation#GO:0002694;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;positive regulation of leukocyte activation#GO:0002696;regulation of multicellular organismal process#GO:0051239;regulation of T cell activation#GO:0050863;cellular component assembly#GO:0022607;positive regulation of T cell activation#GO:0050870;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of immune system process#GO:0002684;cellular component biogenesis#GO:0044085;positive regulation of cell-cell adhesion#GO:0022409;antigen processing and presentation#GO:0019882;positive regulation of lymphocyte activation#GO:0051251;regulation of immune response#GO:0050776;regulation of cell-cell adhesion#GO:0022407;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;positive regulation of cell adhesion#GO:0045785;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;regulation of leukocyte cell-cell adhesion#GO:1903037;positive regulation of cell activation#GO:0050867;positive regulation of leukocyte cell-cell adhesion#GO:1903039;biological regulation#GO:0065007;regulation of cell adhesion#GO:0030155;positive regulation of response to stimulus#GO:0048584;positive regulation of cellular process#GO:0048522 vesicle#GO:0031982;plasma membrane protein complex#GO:0098797;lysosome#GO:0005764;membrane protein complex#GO:0098796;lytic vacuole membrane#GO:0098852;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endosome membrane#GO:0010008;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;cell periphery#GO:0071944;lysosomal membrane#GO:0005765;vesicle membrane#GO:0012506;membrane#GO:0016020;vacuole#GO:0005773;plasma membrane#GO:0005886;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;late endosome#GO:0005770;protein-containing complex#GO:0032991;late endosome membrane#GO:0031902;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;lytic vacuole#GO:0000323;vacuolar membrane#GO:0005774 major histocompatibility complex protein#PC00149 T cell activation#P00053>MHC-antigen#P01316 HUMAN|HGNC=8946|UniProtKB=O43692 O43692 PI15 PTHR10334:SF63 CYSTEINE-RICH SECRETORY PROTEIN-RELATED PEPTIDASE INHIBITOR 15 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090 HUMAN|HGNC=6984|UniProtKB=P23368 P23368 ME2 PTHR23406:SF27 MALIC ENZYME-RELATED NAD-DEPENDENT MALIC ENZYME, MITOCHONDRIAL oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 oxidoreductase#PC00176 HUMAN|HGNC=29145|UniProtKB=Q7Z7F0 Q7Z7F0 KHDC4 PTHR15744:SF0 BLOM7 KH HOMOLOGY DOMAIN-CONTAINING PROTEIN 4 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;nucleic acid metabolic process#GO:0090304;protein-containing complex assembly#GO:0065003;mRNA splicing, via spliceosome#GO:0000398;protein-RNA complex assembly#GO:0022618;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions#GO:0000375;spliceosomal complex assembly#GO:0000245;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;cellular component assembly#GO:0022607;mRNA splice site recognition#GO:0006376;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;mRNA processing#GO:0006397;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein-RNA complex organization#GO:0071826;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;spliceosomal complex#GO:0005681 HUMAN|HGNC=31960|UniProtKB=Q4V326 Q4V326 GAGE2E PTHR14047:SF30 P ANTIGEN FAMILY MEMBER 5-RELATED G ANTIGEN 1-RELATED HUMAN|HGNC=13546|UniProtKB=Q9NRF9 Q9NRF9 POLE3 PTHR46172:SF1 DNA POLYMERASE EPSILON SUBUNIT 3 DNA POLYMERASE EPSILON SUBUNIT 3 nucleic acid binding#GO:0003676;binding#GO:0005488;chromatin binding#GO:0003682;chromatin DNA binding#GO:0031490;DNA binding#GO:0003677 cellular response to stress#GO:0033554;DNA damage response#GO:0006974;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;DNA-templated DNA replication#GO:0006261;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;DNA replication#GO:0006260;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;primary metabolic process#GO:0044238;DNA strand elongation involved in DNA replication#GO:0006271;nucleobase-containing compound metabolic process#GO:0006139;response to stimulus#GO:0050896 ISWI-type complex#GO:0031010;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;ATPase complex#GO:1904949;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;chromosome#GO:0005694;SWI/SNF superfamily-type complex#GO:0070603;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;epsilon DNA polymerase complex#GO:0008622;intracellular protein-containing complex#GO:0140535;DNA polymerase complex#GO:0042575;transferase complex#GO:1990234;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;membrane-enclosed lumen#GO:0031974;chromatin#GO:0000785;nucleus#GO:0005634 DNA metabolism protein#PC00009 HUMAN|HGNC=18624|UniProtKB=Q9NYL4 Q9NYL4 FKBP11 PTHR45779:SF2 PEPTIDYLPROLYL ISOMERASE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP11 cis-trans isomerase activity#GO:0016859;isomerase activity#GO:0016853;peptidyl-prolyl cis-trans isomerase activity#GO:0003755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 HUMAN|HGNC=19169|UniProtKB=O95772 O95772 STARD3NL PTHR46121:SF1 STEROIDOGENIC ACUTE REGULATORY PROTEIN-LIKE STARD3 N-TERMINAL-LIKE PROTEIN cholesterol binding#GO:0015485;lipid binding#GO:0008289;steroid binding#GO:0005496;alcohol binding#GO:0043178;sterol binding#GO:0032934;small molecule binding#GO:0036094;binding#GO:0005488 lipid transport#GO:0006869;macromolecule localization#GO:0033036;cholesterol transport#GO:0030301;localization#GO:0051179;establishment of localization#GO:0051234;sterol transport#GO:0015918;organic hydroxy compound transport#GO:0015850;lipid localization#GO:0010876;transport#GO:0006810 bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;endoplasmic reticulum#GO:0005783;late endosome membrane#GO:0031902;endoplasmic reticulum membrane#GO:0005789;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;late endosome#GO:0005770;vesicle membrane#GO:0012506;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endosome membrane#GO:0010008;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;organelle membrane contact site#GO:0044232 HUMAN|HGNC=37269|UniProtKB=A1L167 A1L167 UBE2QL1 PTHR24068:SF72 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2Q-LIKE PROTEIN 1 ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein conjugating enzyme activity#GO:0061650;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin conjugating enzyme activity#GO:0061631;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824 protein modification process#GO:0036211;primary metabolic process#GO:0044238;cellular process#GO:0009987;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=1097|UniProtKB=P15056 P15056 BRAF PTHR44329:SF240 SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED SERINE_THREONINE-PROTEIN KINASE B-RAF protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;MAP kinase kinase kinase activity#GO:0004709;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;signaling#GO:0023052;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;MAPK cascade#GO:0000165;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cell periphery#GO:0071944;mitochondrion#GO:0005739;membrane#GO:0016020;cytosol#GO:0005829 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Integrin signalling pathway#P00034>Raf#P00924;Interleukin signaling pathway#P00036>Raf#P00983;PDGF signaling pathway#P00047>Raf#P01161;VEGF signaling pathway#P00056>Raf#P01417;CCKR signaling map#P06959>B-Raf#P07057;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Raf-1#P00843;T cell activation#P00053>Raf#P01311;EGF receptor signaling pathway#P00018>Raf-1#P00560;Angiogenesis#P00005>Raf#P00243;Ras Pathway#P04393>Raf#P04556;Integrin signalling pathway#P00034>B-Raf#P00911;B cell activation#P00010>Raf#P00381 HUMAN|HGNC=4008|UniProtKB=Q9BTY2 Q9BTY2 FUCA2 PTHR10030:SF45 ALPHA-L-FUCOSIDASE PLASMA ALPHA-L-FUCOSIDASE hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787 monosaccharide metabolic process#GO:0005996;metabolic process#GO:0008152;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;glycosyl compound catabolic process#GO:1901658;hexose metabolic process#GO:0019318;primary metabolic process#GO:0044238;carbohydrate derivative catabolic process#GO:1901136;carbohydrate metabolic process#GO:0005975;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056 hydrolase#PC00121;glycosidase#PC00110 HUMAN|HGNC=1464|UniProtKB=Q16566 Q16566 CAMK4 PTHR24349:SF243 SERINE/THREONINE-PROTEIN KINASE CALCIUM_CALMODULIN-DEPENDENT PROTEIN KINASE TYPE IV calmodulin binding#GO:0005516;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;binding#GO:0005488;calcium/calmodulin-dependent protein kinase activity#GO:0004683;protein binding#GO:0005515;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 CCKR signaling map#P06959>CaMKIV#P07198 HUMAN|HGNC=5104|UniProtKB=O43365 O43365 HOXA3 PTHR45664:SF13 PROTEIN ZERKNUELLT 1-RELATED HOMEOBOX PROTEIN HOX-A3 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;developmental process#GO:0032502;regulation of nucleobase-containing compound metabolic process#GO:0019219;regionalization#GO:0003002;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;skeletal system morphogenesis#GO:0048705;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;pattern specification process#GO:0007389;embryo development ending in birth or egg hatching#GO:0009792;embryonic organ development#GO:0048568;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;animal organ morphogenesis#GO:0009887;multicellular organism development#GO:0007275;embryonic morphogenesis#GO:0048598;animal organ development#GO:0048513;anterior/posterior pattern specification#GO:0009952;embryo development#GO:0009790;skeletal system development#GO:0001501;animal gross anatomical part developmental process#GO:0160108;chordate embryonic development#GO:0043009;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 homeodomain transcription factor#PC00119 HUMAN|HGNC=18078|UniProtKB=O95365 O95365 ZBTB7A PTHR46105:SF6 AGAP004733-PA ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 7A sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=1066|UniProtKB=P35226 P35226 BMI1 PTHR10825:SF21 RING FINGER DOMAIN-CONTAINING, POLYCOMB GROUP COMPONENT POLYCOMB COMPLEX PROTEIN BMI-1 binding#GO:0005488;chromatin binding#GO:0003682 regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 protein-containing complex#GO:0032991;nucleus#GO:0005634;PcG protein complex#GO:0031519;intracellular protein-containing complex#GO:0140535;PRC1 complex#GO:0035102;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear ubiquitin ligase complex#GO:0000152;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 histone modifying enzyme#PC00261 HUMAN|HGNC=30014|UniProtKB=Q96LB9 Q96LB9 PGLYRP3 PTHR11022:SF12 PEPTIDOGLYCAN RECOGNITION PROTEIN PEPTIDOGLYCAN RECOGNITION PROTEIN 3 signaling receptor activity#GO:0038023;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;catalytic activity#GO:0003824;pattern recognition receptor activity#GO:0038187;molecular transducer activity#GO:0060089;hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;N-acetylmuramoyl-L-alanine amidase activity#GO:0008745;peptidoglycan muralytic activity#GO:0061783 defense response to bacterium#GO:0042742;immune system process#GO:0002376;response to bacterium#GO:0009617;response to external stimulus#GO:0009605;defense response#GO:0006952;defense response to Gram-positive bacterium#GO:0050830;immune response#GO:0006955;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to other organism#GO:0051707;response to stimulus#GO:0050896 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090 HUMAN|HGNC=20126|UniProtKB=Q96F83 Q96F83 CLBA1 PTHR16156:SF7 AFTIPHILIN A-RELATED CLATHRIN BINDING BOX OF AFTIPHILIN CONTAINING 1 clathrin binding#GO:0030276;binding#GO:0005488;protein binding#GO:0005515 membrane coat#GO:0030117;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;trans-Golgi network transport vesicle#GO:0030140;AP-1 adaptor complex#GO:0030121;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;vesicle#GO:0031982;organelle membrane#GO:0031090;clathrin-coated vesicle#GO:0030136;Golgi apparatus#GO:0005794;trans-Golgi network transport vesicle membrane#GO:0012510;Golgi-associated vesicle#GO:0005798;transport vesicle membrane#GO:0030658;endomembrane system#GO:0012505;transport vesicle#GO:0030133;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;vesicle membrane#GO:0012506;coated membrane#GO:0048475;coated vesicle#GO:0030135;organelle subcompartment#GO:0031984;intracellular organelle#GO:0043229;clathrin coat#GO:0030118;cellular anatomical structure#GO:0110165;organelle#GO:0043226;Golgi-associated vesicle membrane#GO:0030660;coated vesicle membrane#GO:0030662;intracellular vesicle#GO:0097708;clathrin-coated vesicle membrane#GO:0030665;bounding membrane of organelle#GO:0098588;AP-type membrane coat adaptor complex#GO:0030119;clathrin vesicle coat#GO:0030125;trans-Golgi network membrane#GO:0032588;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;vesicle coat#GO:0030120 HUMAN|HGNC=19920|UniProtKB=Q8IW50 Q8IW50 FAM219A PTHR31281:SF0 PROTEIN FAM219A PROTEIN FAM219A HUMAN|HGNC=13148|UniProtKB=Q92670 Q92670 ZNF75CP PTHR23226:SF142 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER PROTEIN 75C-RELATED transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=2187|UniProtKB=P13942 P13942 COL11A2 PTHR24023:SF509 COLLAGEN ALPHA COLLAGEN ALPHA-2(XI) CHAIN extracellular matrix structural constituent#GO:0005201;structural molecule activity#GO:0005198 cellular component organization#GO:0016043;sensory perception of sound#GO:0007605;animal gross anatomical part developmental process#GO:0160108;extracellular structure organization#GO:0043062;nervous system process#GO:0050877;sensory perception of mechanical stimulus#GO:0050954;sensory perception#GO:0007600;anatomical structure development#GO:0048856;extracellular matrix organization#GO:0030198;skeletal system development#GO:0001501;cartilage development#GO:0051216;system development#GO:0048731;external encapsulating structure organization#GO:0045229;cellular process#GO:0009987;multicellular organismal process#GO:0032501;tissue development#GO:0009888;developmental process#GO:0032502;animal organ development#GO:0048513;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;connective tissue development#GO:0061448;system process#GO:0003008 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 Integrin signalling pathway#P00034>Collagen#P00922 HUMAN|HGNC=32698|UniProtKB=Q1HG44 Q1HG44 DUOXA2 PTHR31158:SF2 DUAL OXIDASE 2 DUAL OXIDASE MATURATION FACTOR 2 membrane#GO:0016020;cellular anatomical structure#GO:0110165 oxidase#PC00175;oxidoreductase#PC00176 HUMAN|HGNC=622|UniProtKB=Q92624 Q92624 APPBP2 PTHR46575:SF1 AMYLOID PROTEIN-BINDING PROTEIN 2 AMYLOID PROTEIN-BINDING PROTEIN 2 ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;Cul2-RING ubiquitin ligase complex#GO:0031462;catalytic complex#GO:1902494;transferase complex#GO:1990234 HUMAN|HGNC=19347|UniProtKB=O14529 O14529 CUX2 PTHR14043:SF5 CCAAT DISPLACEMENT PROTEIN-RELATED HOMEOBOX PROTEIN CUT-LIKE 2 double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=12490|UniProtKB=O14933 O14933 UBE2L6 PTHR24068:SF43 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN_ISG15-CONJUGATING ENZYME E2 L6 aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin conjugating enzyme activity#GO:0061631;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein conjugating enzyme activity#GO:0061650;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746 macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein modification by small protein conjugation or removal#GO:0070647;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;catabolic process#GO:0009056;protein modification process#GO:0036211;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;cellular process#GO:0009987 ubiquitin-protein ligase#PC00234 Ubiquitin proteasome pathway#P00060>E2#P01491;Parkinson disease#P00049>UbcH8#P01223 HUMAN|HGNC=14214|UniProtKB=Q96RK0 Q96RK0 CIC PTHR13059:SF13 HMG-BOX TRANSCRIPTION FACTOR BBX PROTEIN CAPICUA HOMOLOG sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HMG box transcription factor#PC00024;DNA-binding transcription factor#PC00218 HUMAN|HGNC=34343|UniProtKB=Q6ZV65 Q6ZV65 FAM47E PTHR46449:SF3 ZGC:158260 PROTEIN FAM47E regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulation of gene expression#GO:0010468;positive regulation of gene expression#GO:0010628;transcription by RNA polymerase II#GO:0006366;biosynthetic process#GO:0009058;chromatin organization#GO:0006325;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;epigenetic regulation of gene expression#GO:0040029;macromolecule biosynthetic process#GO:0009059;positive regulation of cellular process#GO:0048522;positive regulation of biosynthetic process#GO:0009891;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;transcription initiation-coupled chromatin remodeling#GO:0045815;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;gene expression#GO:0010467;positive regulation of macromolecule metabolic process#GO:0010604;transcription initiation at RNA polymerase II promoter#GO:0006367;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;RNA metabolic process#GO:0016070;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;nucleic acid biosynthetic process#GO:0141187;DNA-templated transcription initiation#GO:0006352;chromatin remodeling#GO:0006338;cellular component organization#GO:0016043;regulation of biological process#GO:0050789 intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165;chromatin#GO:0000785;chromosome#GO:0005694;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229 HUMAN|HGNC=13938|UniProtKB=Q5SSQ6 Q5SSQ6 SAPCD1 PTHR14907:SF4 FI14130P SUPPRESSOR APC DOMAIN-CONTAINING PROTEIN 1 HUMAN|HGNC=14077|UniProtKB=Q9NPG2 Q9NPG2 NGB PTHR46458:SF1 BLR2807 PROTEIN NEUROGLOBIN molecular carrier activity#GO:0140104;binding#GO:0005488;small molecule binding#GO:0036094 transport#GO:0006810;establishment of localization#GO:0051234;localization#GO:0051179;response to hypoxia#GO:0001666;response to stress#GO:0006950;response to abiotic stimulus#GO:0009628;response to oxygen levels#GO:0070482;response to decreased oxygen levels#GO:0036293;response to stimulus#GO:0050896 transporter#PC00227 HUMAN|HGNC=16254|UniProtKB=Q8TDR2 Q8TDR2 STK35 PTHR11042:SF59 EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED SERINE_THREONINE-PROTEIN KINASE 35 catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 post-transcriptional regulation of gene expression#GO:0010608;regulation of translational initiation#GO:0006446;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=13488|UniProtKB=Q9UN37 Q9UN37 VPS4A PTHR23074:SF83 AAA DOMAIN-CONTAINING VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP-dependent activity#GO:0140657 establishment of localization in cell#GO:0051649;cellular process#GO:0009987;multivesicular body sorting pathway#GO:0071985;organelle organization#GO:0006996;endosome transport via multivesicular body sorting pathway#GO:0032509;vesicle-mediated transport#GO:0016192;ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043162;transport#GO:0006810;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;intracellular transport#GO:0046907;endosomal transport#GO:0016197;ubiquitin-dependent protein catabolic process#GO:0006511;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;establishment of localization#GO:0051234;modification-dependent protein catabolic process#GO:0019941;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;catabolic process#GO:0009056;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;vacuole organization#GO:0007033;localization#GO:0051179;protein metabolic process#GO:0019538;cellular localization#GO:0051641 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular vesicle#GO:0097708;vesicle#GO:0031982;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768 microtubule or microtubule-binding cytoskeletal protein#PC00157;non-motor microtubule binding protein#PC00166 HUMAN|HGNC=17853|UniProtKB=Q9P2D0 Q9P2D0 IBTK PTHR22872:SF15 BTK-BINDING PROTEIN-RELATED INHIBITOR OF BRUTON TYROSINE KINASE molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;protein binding#GO:0005515;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;kinase binding#GO:0019900;binding#GO:0005488;protein kinase regulator activity#GO:0019887;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;protein kinase inhibitor activity#GO:0004860;kinase inhibitor activity#GO:0019210;enzyme inhibitor activity#GO:0004857 calcium ion transmembrane transport#GO:0070588;release of sequestered calcium ion into cytosol#GO:0051209;cellular process#GO:0009987;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;calcium ion transmembrane import into cytosol#GO:0097553;monoatomic ion transport#GO:0006811;calcium ion transport#GO:0006816 nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 HUMAN|HGNC=7132|UniProtKB=Q03164 Q03164 KMT2A PTHR45838:SF2 HISTONE-LYSINE-N-METHYLTRANSFERASE 2 KMT2 FAMILY MEMBER HISTONE-LYSINE N-METHYLTRANSFERASE 2A S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;N-methyltransferase activity#GO:0008170;histone methyltransferase activity#GO:0042054;protein-lysine N-methyltransferase activity#GO:0016279;histone modifying activity#GO:0140993;histone H3 methyltransferase activity#GO:0140938;histone H3K4 methyltransferase activity#GO:0042800;lysine N-methyltransferase activity#GO:0016278;transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein methyltransferase activity#GO:0008276;catalytic activity, acting on a protein#GO:0140096 positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of RNA metabolic process#GO:0051252 organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;methyltransferase complex#GO:0034708;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;protein-containing complex#GO:0032991;histone methyltransferase complex#GO:0035097;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513 histone modifying enzyme#PC00261;chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=31374|UniProtKB=P60827 P60827 C1QTNF8 PTHR22923:SF117 CEREBELLIN-RELATED COMPLEMENT C1Q TUMOR NECROSIS FACTOR-RELATED PROTEIN 8 molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545 positive regulation of locomotion#GO:0040017;regulation of cell motility#GO:2000145;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;regulation of cellular process#GO:0050794;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789;positive regulation of cell motility#GO:2000147 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=8158|UniProtKB=Q9UBM4 Q9UBM4 OPTC PTHR46269:SF4 EPIPHYCAN-RELATED OPTICIN developmental process#GO:0032502;connective tissue development#GO:0061448;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;animal organ development#GO:0048513;bone development#GO:0060348;cellular process#GO:0009987;multicellular organismal process#GO:0032501;tissue development#GO:0009888;extracellular structure organization#GO:0043062;animal gross anatomical part developmental process#GO:0160108;external encapsulating structure organization#GO:0045229;system development#GO:0048731;cartilage development#GO:0051216;skeletal system development#GO:0001501;anatomical structure development#GO:0048856;collagen fibril organization#GO:0030199;extracellular matrix organization#GO:0030198;cellular component organization#GO:0016043 extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cellular anatomical structure#GO:0110165 HUMAN|HGNC=10776|UniProtKB=Q8N474 Q8N474 SFRP1 PTHR11309:SF87 FRIZZLED SECRETED FRIZZLED-RELATED PROTEIN 1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;protein binding#GO:0005515;Wnt-protein binding#GO:0017147;transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488 cell communication#GO:0007154;canonical Wnt signaling pathway#GO:0060070;cell surface receptor signaling pathway#GO:0007166;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;Wnt signaling pathway#GO:0016055;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;non-canonical Wnt signaling pathway#GO:0035567 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;extracellular region#GO:0005576 transmembrane signal receptor#PC00197 Wnt signaling pathway#P00057>sFRP#P01434;Angiogenesis#P00005>FRP#P00237 HUMAN|HGNC=6701|UniProtKB=P30533 P30533 LRPAP1 PTHR16560:SF2 ALPHA-2-MACROGLOBULIN RECEPTOR-ASSOCIATED PROTEIN ALPHA-2-MACROGLOBULIN RECEPTOR-ASSOCIATED PROTEIN molecular function regulator activity#GO:0098772;signaling receptor regulator activity#GO:0030545;signaling receptor inhibitor activity#GO:0030547;lipoprotein particle receptor binding#GO:0070325;molecular function inhibitor activity#GO:0140678;protein binding#GO:0005515;enzyme binding#GO:0019899;binding#GO:0005488;signaling receptor binding#GO:0005102 regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;negative regulation of multicellular organismal process#GO:0051241;negative regulation of biological process#GO:0048519;negative regulation of cellular component organization#GO:0051129;biological regulation#GO:0065007;regulation of multicellular organismal process#GO:0051239;negative regulation of transport#GO:0051051;regulation of cellular component organization#GO:0051128;regulation of receptor-mediated endocytosis#GO:0048259;regulation of cellular process#GO:0050794;regulation of endocytosis#GO:0030100;negative regulation of cellular process#GO:0048523;regulation of localization#GO:0032879;regulation of transport#GO:0051049 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;organelle lumen#GO:0043233;vesicle#GO:0031982;rough endoplasmic reticulum#GO:0005791;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;endosome#GO:0005768;endomembrane system#GO:0012505;plasma membrane#GO:0005886;cytoplasm#GO:0005737;endoplasmic reticulum lumen#GO:0005788;membrane#GO:0016020;membrane-enclosed lumen#GO:0031974;cell periphery#GO:0071944;cis-Golgi network#GO:0005801;Golgi apparatus#GO:0005794;endoplasmic reticulum#GO:0005783 chaperone#PC00072 HUMAN|HGNC=13506|UniProtKB=Q8TBJ5 Q8TBJ5 FEZF2 PTHR16515:SF35 PR DOMAIN ZINC FINGER PROTEIN FEZ FAMILY ZINC FINGER PROTEIN 2 regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264;zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=7643|UniProtKB=O43776 O43776 NARS1 PTHR22594:SF16 ASPARTYL/LYSYL-TRNA SYNTHETASE ASPARAGINE--TRNA LIGASE, CYTOPLASMIC ligase activity#GO:0016874;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098 protein metabolic process#GO:0019538;RNA metabolic process#GO:0016070;translation#GO:0006412;protein biosynthetic process#GO:0160307;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;amino acid activation#GO:0043038;macromolecule metabolic process#GO:0043170;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;amino acid metabolic process#GO:0006520;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;tRNA aminoacylation for protein translation#GO:0006418;tRNA aminoacylation#GO:0043039 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 translational protein#PC00263;aminoacyl-tRNA synthetase#PC00047 HUMAN|HGNC=26888|UniProtKB=Q8N2R8 Q8N2R8 FAM43A PTHR11232:SF36 PHOSPHOTYROSINE INTERACTION DOMAIN-CONTAINING FAMILY MEMBER PROTEIN FAM43A protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;signaling adaptor activity#GO:0035591 scaffold/adaptor protein#PC00226 HUMAN|HGNC=34354|UniProtKB=A6NJJ6 A6NJJ6 C19orf67 PTHR36292:SF1 UPF0575 PROTEIN C19ORF67 UPF0575 PROTEIN C19ORF67 HUMAN|HGNC=19848|UniProtKB=Q6ZRR7 Q6ZRR7 LRRC9 PTHR46652:SF3 LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9 HUMAN|HGNC=8896|UniProtKB=P00558 P00558 PGK1 PTHR11406:SF14 PHOSPHOGLYCERATE KINASE PHOSPHOGLYCERATE KINASE 1 nucleotide binding#GO:0000166;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, carboxyl group as acceptor#GO:0016774;catalytic activity#GO:0003824;phosphoglycerate kinase activity#GO:0004618;ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;kinase activity#GO:0016301;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;transferase activity#GO:0016740;purine nucleotide binding#GO:0017076;nucleoside phosphate binding#GO:1901265;ATP binding#GO:0005524;binding#GO:0005488 purine ribonucleotide metabolic process#GO:0009150;monosaccharide metabolic process#GO:0005996;metabolic process#GO:0008152;glucose metabolic process#GO:0006006;purine-containing compound catabolic process#GO:0072523;ATP metabolic process#GO:0046034;nicotinamide nucleotide metabolic process#GO:0046496;gluconeogenesis#GO:0006094;oxoacid metabolic process#GO:0043436;ribonucleoside diphosphate metabolic process#GO:0009185;carboxylic acid metabolic process#GO:0019752;phosphorus metabolic process#GO:0006793;pyridine nucleotide catabolic process#GO:0019364;small molecule metabolic process#GO:0044281;small molecule biosynthetic process#GO:0044283;nucleotide catabolic process#GO:0009166;energy derivation by oxidation of organic compounds#GO:0015980;carbohydrate derivative metabolic process#GO:1901135;ribonucleotide catabolic process#GO:0009261;nucleobase-containing compound catabolic process#GO:0034655;nucleobase-containing compound metabolic process#GO:0006139;purine nucleotide catabolic process#GO:0006195;cellular respiration#GO:0045333;organophosphate catabolic process#GO:0046434;ribonucleoside diphosphate catabolic process#GO:0009191;nucleoside diphosphate catabolic process#GO:0009134;purine ribonucleotide catabolic process#GO:0009154;hexose biosynthetic process#GO:0019319;nucleoside phosphate metabolic process#GO:0006753;carbohydrate metabolic process#GO:0005975;catabolic process#GO:0009056;ADP catabolic process#GO:0046032;purine nucleoside diphosphate catabolic process#GO:0009137;nucleobase-containing small molecule metabolic process#GO:0055086;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;carbohydrate biosynthetic process#GO:0016051;purine nucleoside diphosphate metabolic process#GO:0009135;ribonucleotide metabolic process#GO:0009259;nucleotide metabolic process#GO:0009117;carbohydrate catabolic process#GO:0016052;pyridine-containing compound catabolic process#GO:0072526;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;monocarboxylic acid metabolic process#GO:0032787;pyruvate metabolic process#GO:0006090;purine ribonucleoside diphosphate metabolic process#GO:0009179;generation of precursor metabolites and energy#GO:0006091;ADP metabolic process#GO:0046031;glycolytic process#GO:0006096;purine ribonucleoside triphosphate metabolic process#GO:0009205;organophosphate metabolic process#GO:0019637;monosaccharide biosynthetic process#GO:0046364;biosynthetic process#GO:0009058;pyridine-containing compound metabolic process#GO:0072524;nucleoside diphosphate metabolic process#GO:0009132;aerobic respiration#GO:0009060;purine ribonucleoside diphosphate catabolic process#GO:0009181;purine nucleoside triphosphate metabolic process#GO:0009144;hexose metabolic process#GO:0019318;primary metabolic process#GO:0044238;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate derivative catabolic process#GO:1901136;nucleoside phosphate catabolic process#GO:1901292 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 carbohydrate kinase#PC00065 Glycolysis#P00024>Phosphoglycerate kinase#P00671 HUMAN|HGNC=2754|UniProtKB=Q9NUI1 Q9NUI1 DECR2 PTHR43296:SF12 PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE [(3E)-ENOYL-COA-PRODUCING] catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;oxidoreductase activity#GO:0016491 lipid metabolic process#GO:0006629;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;small molecule metabolic process#GO:0044281;cellular process#GO:0009987;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;peroxisome#GO:0005777;microbody#GO:0042579 reductase#PC00198 HUMAN|HGNC=4325|UniProtKB=O95838 O95838 GLP2R PTHR45620:SF23 PDF RECEPTOR-LIKE PROTEIN-RELATED GLUCAGON-LIKE PEPTIDE 2 RECEPTOR G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888 signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;G protein-coupled receptor signaling pathway#GO:0007186 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=17001|UniProtKB=P48060 P48060 GLIPR1 PTHR10334:SF459 CYSTEINE-RICH SECRETORY PROTEIN-RELATED GLIOMA PATHOGENESIS-RELATED PROTEIN 1 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090 HUMAN|HGNC=19414|UniProtKB=Q6NUT2 Q6NUT2 DPY19L2 PTHR31488:SF6 DPY-19-LIKE 1, LIKE (H. SAPIENS) C-MANNOSYLTRANSFERASE DPY19L2-RELATED glycosyltransferase activity#GO:0016757;mannosyltransferase activity#GO:0000030;transferase activity#GO:0016740;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 cellular process#GO:0009987;male gamete generation#GO:0048232;developmental process#GO:0032502;spermatogenesis#GO:0007283;cellular developmental process#GO:0048869;developmental process involved in reproduction#GO:0003006;germ cell development#GO:0007281;gamete generation#GO:0007276;cell differentiation#GO:0030154;reproductive process#GO:0022414;cell development#GO:0048468;cellular process involved in reproduction in multicellular organism#GO:0022412;spermatid differentiation#GO:0048515;spermatid development#GO:0007286;sexual reproduction#GO:0019953;anatomical structure development#GO:0048856;multicellular organismal reproductive process#GO:0048609 organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle inner membrane#GO:0019866;membrane#GO:0016020;nuclear envelope#GO:0005635;cytoplasm#GO:0005737;endomembrane system#GO:0012505;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;nuclear inner membrane#GO:0005637;nuclear membrane#GO:0031965;organelle membrane#GO:0031090 HUMAN|HGNC=26877|UniProtKB=Q8IYA6 Q8IYA6 CKAP2L PTHR47078:SF1 CYTOSKELETON-ASSOCIATED PROTEIN 2-LIKE CYTOSKELETON-ASSOCIATED PROTEIN 2-LIKE mitotic spindle#GO:0072686;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microtubule cytoskeleton#GO:0015630;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;spindle#GO:0005819;centrosome#GO:0005813;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856 HUMAN|HGNC=4651|UniProtKB=P29084 P29084 GTF2E2 PTHR12716:SF8 TRANSCRIPTION INITIATION FACTOR IIE, BETA SUBUNIT TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA RNA polymerase binding#GO:0070063;enzyme binding#GO:0019899;transcription factor binding#GO:0008134;binding#GO:0005488;RNA polymerase core enzyme binding#GO:0043175;protein binding#GO:0005515;RNA polymerase II complex binding#GO:0000993 gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;transcription initiation at RNA polymerase II promoter#GO:0006367;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;transcription by RNA polymerase II#GO:0006366;DNA-templated transcription initiation#GO:0006352;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187 RNA polymerase II, holoenzyme#GO:0016591;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;transcription regulator complex#GO:0005667;transferase complex#GO:1990234;protein-containing complex#GO:0032991;membrane-enclosed lumen#GO:0031974;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;RNA polymerase complex#GO:0030880 RNA metabolism protein#PC00031;general transcription factor#PC00259 General transcription regulation#P00023>TFIIE#P00666;General transcription regulation#P00023>TFIIEbeta#P00659;Transcription regulation by bZIP transcription factor#P00055>TFIIEbeta#P01386;Transcription regulation by bZIP transcription factor#P00055>TFIIE#P01395 HUMAN|HGNC=1801|UniProtKB=O95674 O95674 CDS2 PTHR13773:SF4 PHOSPHATIDATE CYTIDYLYLTRANSFERASE PHOSPHATIDATE CYTIDYLYLTRANSFERASE 2 nucleotidyltransferase activity#GO:0016779;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772 lipid droplet organization#GO:0034389;organelle assembly#GO:0070925;organophosphate biosynthetic process#GO:0090407;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;phospholipid biosynthetic process#GO:0008654;glycerolipid metabolic process#GO:0046486;phospholipid metabolic process#GO:0006644;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474;cellular component organization or biogenesis#GO:0071840;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;organophosphate metabolic process#GO:0019637;glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987;lipid storage#GO:0019915;lipid biosynthetic process#GO:0008610;glycerophospholipid metabolic process#GO:0006650;cellular component assembly#GO:0022607;biosynthetic process#GO:0009058 endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 transferase#PC00220 HUMAN|HGNC=40049|UniProtKB=A6NCL1 A6NCL1 GMNC PTHR13372:SF2 GEMININ GEMININ COILED-COIL DOMAIN-CONTAINING PROTEIN 1 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of DNA-templated DNA replication initiation#GO:0030174;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of DNA-templated DNA replication#GO:0090329;regulation of DNA metabolic process#GO:0051052;regulation of DNA replication#GO:0006275 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=10478|UniProtKB=P28702 P28702 RXRB PTHR24083:SF90 NUCLEAR HORMONE RECEPTOR RETINOIC ACID RECEPTOR RXR-BETA transcription regulator activity#GO:0140110;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulatory region nucleic acid binding#GO:0001067;signaling receptor activity#GO:0038023;sequence-specific DNA binding#GO:0043565;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;nuclear receptor activity#GO:0004879;molecular transducer activity#GO:0060089;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific double-stranded DNA binding#GO:1990837 regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;positive regulation of biosynthetic process#GO:0009891;cell communication#GO:0007154;regulation of RNA metabolic process#GO:0051252;intracellular signal transduction#GO:0035556;system development#GO:0048731;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;intracellular receptor signaling pathway#GO:0030522;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of DNA-templated transcription#GO:0045893;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;nuclear receptor-mediated signaling pathway#GO:0141193;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;animal gross anatomical part developmental process#GO:0160108;cellular response to chemical stimulus#GO:0070887;hormone-mediated signaling pathway#GO:0009755;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;cellular response to hormone stimulus#GO:0032870;cell differentiation#GO:0030154;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;cellular response to endogenous stimulus#GO:0071495;signaling#GO:0023052;positive regulation of transcription by RNA polymerase II#GO:0045944;multicellular organism development#GO:0007275;response to hormone#GO:0009725;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;response to chemical#GO:0042221;positive regulation of macromolecule metabolic process#GO:0010604;nervous system development#GO:0007399 nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634 C4 zinc finger nuclear receptor#PC00169;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=23029|UniProtKB=Q9H4B8 Q9H4B8 DPEP3 PTHR10443:SF14 MICROSOMAL DIPEPTIDASE DIPEPTIDASE 3 catalytic activity#GO:0003824;exopeptidase activity#GO:0008238;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;protease#PC00190 HUMAN|HGNC=15184|UniProtKB=Q8NGF9 Q8NGF9 OR4X2 PTHR48002:SF146 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 4X2 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=15944|UniProtKB=P09093 P09093 CELA3A PTHR24257:SF11 CHYMOTRYPSIN-LIKE ELASTASE FAMILY MEMBER CHYMOTRYPSIN-LIKE ELASTASE FAMILY MEMBER 3A serine-type peptidase activity#GO:0008236;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252 primary metabolic process#GO:0044238;proteolysis#GO:0006508;metabolic process#GO:0008152;cellular process#GO:0009987;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;protease#PC00190;serine protease#PC00203 HUMAN|HGNC=10435|UniProtKB=Q9UK32 Q9UK32 RPS6KA6 PTHR24351:SF98 RIBOSOMAL PROTEIN S6 KINASE RIBOSOMAL PROTEIN S6 KINASE ALPHA-6 protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824 signal transduction#GO:0007165;cellular process#GO:0009987;response to stress#GO:0006950;biological regulation#GO:0065007;TOR signaling#GO:0031929;DNA damage response#GO:0006974;signal transduction in response to DNA damage#GO:0042770;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cellular response to stress#GO:0033554;signal transduction by p53 class mediator#GO:0072331;intracellular signal transduction#GO:0035556;TORC1 signaling#GO:0038202;cell communication#GO:0007154 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 protein modifying enzyme#PC00260 PDGF signaling pathway#P00047>p90RSK#P01142;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>P90 RSK#P00888;Ras Pathway#P04393>p90RSK#P04541;Interleukin signaling pathway#P00036>p90RSK#P00964 HUMAN|HGNC=9998|UniProtKB=P41220 P41220 RGS2 PTHR10845:SF43 REGULATOR OF G PROTEIN SIGNALING REGULATOR OF G PROTEIN SIGNALING 2 enzyme activator activity#GO:0008047;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234 negative regulation of cell communication#GO:0010648;negative regulation of signaling#GO:0023057;negative regulation of cellular process#GO:0048523;regulation of G protein-coupled receptor signaling pathway#GO:0008277;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;regulation of cellular process#GO:0050794;negative regulation of response to stimulus#GO:0048585;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;negative regulation of signal transduction#GO:0009968;negative regulation of biological process#GO:0048519;negative regulation of G protein-coupled receptor signaling pathway#GO:0045744;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;plasma membrane#GO:0005886;cytoplasmic side of plasma membrane#GO:0009898;membrane#GO:0016020;cytoplasmic side of membrane#GO:0098562;cell periphery#GO:0071944 GTPase-activating protein#PC00257 CCKR signaling map#P06959>RGS2#P07040;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>RGS#P00704;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>RGS#P00731 HUMAN|HGNC=12849|UniProtKB=P31946 P31946 YWHAB PTHR18860:SF28 14-3-3 PROTEIN 14-3-3 PROTEIN BETA_ALPHA scaffold/adaptor protein#PC00226 FGF signaling pathway#P00021>14-3-3#P00624;EGF receptor signaling pathway#P00018>14-3-3#P00539;Parkinson disease#P00049>14-3-3#P01238;CCKR signaling map#P06959>14-3-3 beta/alpha#P07038 HUMAN|HGNC=24575|UniProtKB=Q9Y248 Q9Y248 GINS2 PTHR12772:SF0 DNA REPLICATION COMPLEX GINS PROTEIN PSF2 DNA REPLICATION COMPLEX GINS PROTEIN PSF2 recombinational repair#GO:0000725;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;double-strand break repair via homologous recombination#GO:0000724;macromolecule metabolic process#GO:0043170;double-strand break repair#GO:0006302;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA recombination#GO:0006310;DNA damage response#GO:0006974;nucleobase-containing compound metabolic process#GO:0006139;response to stress#GO:0006950;double-strand break repair via break-induced replication#GO:0000727;cellular process#GO:0009987 DNA replication preinitiation complex#GO:0031261;chromosome#GO:0005694;organelle lumen#GO:0043233;GINS complex#GO:0000811;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;protein-DNA complex#GO:0032993;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;protein-containing complex#GO:0032991;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228 DNA metabolism protein#PC00009 HUMAN|HGNC=25840|UniProtKB=Q8N371 Q8N371 KDM8 PTHR12461:SF106 HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED BIFUNCTIONAL PEPTIDASE AND ARGINYL-HYDROXYLASE JMJD5 catalytic activity#GO:0003824;histone demethylase activity#GO:0032452;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;protein demethylase activity#GO:0140457;oxidoreductase activity#GO:0016491;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;catalytic activity, acting on a protein#GO:0140096;demethylase activity#GO:0032451;binding#GO:0005488;chromatin binding#GO:0003682;dioxygenase activity#GO:0051213;histone modifying activity#GO:0140993 negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 protein modifying enzyme#PC00260 HUMAN|HGNC=6666|UniProtKB=Q9Y4K0 Q9Y4K0 LOXL2 PTHR45817:SF1 LYSYL OXIDASE-LIKE-RELATED LYSYL OXIDASE HOMOLOG 2 oxidoreductase activity#GO:0016491;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 circulatory system development#GO:0072359;tube morphogenesis#GO:0035239;blood vessel development#GO:0001568;anatomical structure morphogenesis#GO:0009653;blood vessel morphogenesis#GO:0048514;cellular component organization#GO:0016043;system development#GO:0048731;external encapsulating structure organization#GO:0045229;anatomical structure development#GO:0048856;collagen fibril organization#GO:0030199;angiogenesis#GO:0001525;extracellular matrix organization#GO:0030198;extracellular structure organization#GO:0043062;animal gross anatomical part developmental process#GO:0160108;sprouting angiogenesis#GO:0002040;tube development#GO:0035295;multicellular organismal process#GO:0032501;cellular process#GO:0009987;anatomical structure formation involved in morphogenesis#GO:0048646;vasculature development#GO:0001944;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;developmental process#GO:0032502 extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical structure#GO:0110165 oxidase#PC00175;oxidoreductase#PC00176 HUMAN|HGNC=33206|UniProtKB=P0C7X3 P0C7X3 CCNYL3 PTHR14248:SF39 CYCLIN Y, ISOFORM A CYCLIN-Y-LIKE PROTEIN 1B-RELATED enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;kinase activator activity#GO:0019209;cyclin-dependent protein kinase regulator activity#GO:0019914;protein kinase regulator activity#GO:0019887;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538;enzyme activator activity#GO:0008047;protein serine/threonine kinase activator activity#GO:0043539;protein kinase activator activity#GO:0030295 regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of canonical Wnt signaling pathway#GO:0060828;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=14078|UniProtKB=Q9BYV9 Q9BYV9 BACH2 PTHR46105:SF8 AGAP004733-PA TRANSCRIPTION REGULATOR PROTEIN BACH2 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=21288|UniProtKB=Q5T0Z8 Q5T0Z8 C6orf132 PTHR35077:SF2 SIMILAR TO AI661453 PROTEIN SIMILAR TO HUMAN CHROMOSOME 6 OPEN READING FRAME 132 HUMAN|HGNC=6893|UniProtKB=P10636 P10636 MAPT PTHR11501:SF14 MICROTUBULE-ASSOCIATED PROTEIN MICROTUBULE-ASSOCIATED PROTEIN TAU molecular function regulator activity#GO:0098772;tubulin binding#GO:0015631;enzyme inhibitor activity#GO:0004857;cytoskeletal protein binding#GO:0008092;enzyme regulator activity#GO:0030234;protein binding#GO:0005515;molecular function inhibitor activity#GO:0140678;binding#GO:0005488;microtubule binding#GO:0008017 developmental process#GO:0032502;neuron differentiation#GO:0030182;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;microtubule-based process#GO:0007017;neurogenesis#GO:0022008;organelle organization#GO:0006996;neuron projection development#GO:0031175;cellular process#GO:0009987;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;animal gross anatomical part developmental process#GO:0160108;regulation of microtubule-based process#GO:0032886;generation of neurons#GO:0048699;anatomical structure development#GO:0048856;microtubule cytoskeleton organization#GO:0000226;system development#GO:0048731;neuron development#GO:0048666;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;cell differentiation#GO:0030154;cell projection organization#GO:0030030;regulation of microtubule-based movement#GO:0060632;regulation of cellular process#GO:0050794;cell development#GO:0048468 microtubule cytoskeleton#GO:0015630;neuron projection#GO:0043005;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;plasma membrane bounded cell projection#GO:0120025;cytoskeleton#GO:0005856;axon#GO:0030424;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 microtubule or microtubule-binding cytoskeletal protein#PC00157;non-motor microtubule binding protein#PC00166 HUMAN|HGNC=24273|UniProtKB=Q96FB5 Q96FB5 METTL25B PTHR12496:SF2 CGI-41 METHYLTRANSFERASE METHYLTRANSFERASE-LIKE PROTEIN 25B RNA methyltransferase#PC00033 HUMAN|HGNC=7657|UniProtKB=O15394 O15394 NCAM2 PTHR12231:SF231 CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN NEURAL CELL ADHESION MOLECULE 2 protein binding#GO:0005515;binding#GO:0005488;cell adhesion molecule binding#GO:0050839;cell adhesion mediator activity#GO:0098631 neurogenesis#GO:0022008;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;neuron differentiation#GO:0030182;developmental process#GO:0032502;plasma membrane bounded cell projection organization#GO:0120036;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;cellular process#GO:0009987;neuron projection development#GO:0031175;cell-cell adhesion#GO:0098609;axon development#GO:0061564;system development#GO:0048731;neuron development#GO:0048666;anatomical structure development#GO:0048856;generation of neurons#GO:0048699;cell adhesion#GO:0007155;cell recognition#GO:0008037;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cellular component organization#GO:0016043 synaptic membrane#GO:0097060;cell junction#GO:0030054;membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005;synapse#GO:0045202;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;cell projection#GO:0042995 immunoglobulin superfamily cell adhesion molecule#PC00125;cell adhesion molecule#PC00069 HUMAN|HGNC=2730|UniProtKB=Q08345 Q08345 DDR1 PTHR24416:SF333 TYROSINE-PROTEIN KINASE RECEPTOR EPITHELIAL DISCOIDIN DOMAIN-CONTAINING RECEPTOR 1 transmembrane receptor protein kinase activity#GO:0019199;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein tyrosine kinase activity#GO:0004713;catalytic activity#GO:0003824;transmembrane receptor protein tyrosine kinase activity#GO:0004714;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;kinase activity#GO:0016301;transferase activity#GO:0016740;protein kinase activity#GO:0004672;protein-containing complex binding#GO:0044877;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane signaling receptor activity#GO:0004888;collagen binding#GO:0005518;binding#GO:0005488 regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of response to stimulus#GO:0048584;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of signaling#GO:0023056;cell communication#GO:0007154;regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051896;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051897;response to stimulus#GO:0050896;regulation of cell communication#GO:0010646;signaling#GO:0023052;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;signaling receptor complex#GO:0043235;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=1628|UniProtKB=P08571 P08571 CD14 PTHR10630:SF3 MONOCYTE DIFFERENTIATION ANTIGEN CD14 MONOCYTE DIFFERENTIATION ANTIGEN CD14 lipid binding#GO:0008289;lipopolysaccharide binding#GO:0001530;carbohydrate derivative binding#GO:0097367;binding#GO:0005488 cell communication#GO:0007154;positive regulation of biosynthetic process#GO:0009891;response to bacterium#GO:0009617;immune response-activating cell surface receptor signaling pathway#GO:0002429;regulation of response to biotic stimulus#GO:0002831;response to external biotic stimulus#GO:0043207;positive regulation of cytokine production#GO:0001819;regulation of gene expression#GO:0010468;response to external stimulus#GO:0009605;positive regulation of gene expression#GO:0010628;cellular response to molecule of bacterial origin#GO:0071219;regulation of response to stress#GO:0080134;response to other organism#GO:0051707;toll-like receptor 4 signaling pathway#GO:0034142;positive regulation of innate immune response#GO:0045089;regulation of macromolecule biosynthetic process#GO:0010556;activation of innate immune response#GO:0002218;positive regulation of metabolic process#GO:0009893;response to oxygen-containing compound#GO:1901700;biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052;positive regulation of response to external stimulus#GO:0032103;cell surface receptor signaling pathway#GO:0007166;regulation of multicellular organismal process#GO:0051239;response to lipid#GO:0033993;response to chemical#GO:0042221;cellular response to lipopolysaccharide#GO:0071222;regulation of defense response#GO:0031347;regulation of immune response#GO:0050776;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of macromolecule metabolic process#GO:0060255;cellular response to stimulus#GO:0051716;cellular response to biotic stimulus#GO:0071216;innate immune response-activating signaling pathway#GO:0002758;pattern recognition receptor signaling pathway#GO:0002221;positive regulation of response to biotic stimulus#GO:0002833;regulation of biosynthetic process#GO:0009889;regulation of innate immune response#GO:0045088;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;positive regulation of defense response#GO:0031349;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;positive regulation of response to stimulus#GO:0048584;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;regulation of cytokine production#GO:0001817;positive regulation of macromolecule biosynthetic process#GO:0010557;cellular response to chemical stimulus#GO:0070887;immune system process#GO:0002376;response to stimulus#GO:0050896;immune response-regulating signaling pathway#GO:0002764;positive regulation of multicellular organismal process#GO:0051240;regulation of biological process#GO:0050789;response to molecule of bacterial origin#GO:0002237;response to lipopolysaccharide#GO:0032496;immune response-activating signaling pathway#GO:0002757;regulation of response to external stimulus#GO:0032101;cellular response to lipid#GO:0071396;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;activation of immune response#GO:0002253;positive regulation of immune system process#GO:0002684;response to biotic stimulus#GO:0009607 cell periphery#GO:0071944;membrane raft#GO:0045121;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cell surface#GO:0009986;signaling receptor complex#GO:0043235;membrane microdomain#GO:0098857;external side of plasma membrane#GO:0009897;side of membrane#GO:0098552 transmembrane signal receptor#PC00197 Toll receptor signaling pathway#P00054>CD14#P01373 HUMAN|HGNC=13880|UniProtKB=B0I1T2 B0I1T2 MYO1G PTHR13140:SF381 MYOSIN UNCONVENTIONAL MYOSIN-IG cytoskeletal motor activity#GO:0003774;isomerase activity#GO:0016853;microfilament motor activity#GO:0000146;catalytic activity#GO:0003824;polypeptide conformation or assembly isomerase activity#GO:0120544;ATP-dependent activity#GO:0140657;macromolecular conformation isomerase activity#GO:0120543 endocytosis#GO:0006897;actin cytoskeleton organization#GO:0030036;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;organelle organization#GO:0006996;actin filament-based movement#GO:0030048;cellular process#GO:0009987;import into cell#GO:0098657;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;localization#GO:0051179;actin filament organization#GO:0007015;supramolecular fiber organization#GO:0097435;actin filament-based process#GO:0030029;transport#GO:0006810 intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;actin cytoskeleton#GO:0015629;actin-based cell projection#GO:0098858;microvillus#GO:0005902;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;cytoplasm#GO:0005737;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;membrane#GO:0016020;cell periphery#GO:0071944 actin binding motor protein#PC00040 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HUMAN|HGNC=19307|UniProtKB=Q7Z5N4 Q7Z5N4 SDK1 PTHR13817:SF55 TITIN PROTEIN SIDEKICK-1 homophilic cell-cell adhesion#GO:0007156;cellular component biogenesis#GO:0044085;cell-cell adhesion#GO:0098609;cellular process#GO:0009987;cellular component assembly#GO:0022607;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;developmental process#GO:0032502;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cell junction assembly#GO:0034329;cellular component organization#GO:0016043;cell junction organization#GO:0034330;synapse assembly#GO:0007416;animal gross anatomical part developmental process#GO:0160108;synapse organization#GO:0050808;cell adhesion#GO:0007155;anatomical structure development#GO:0048856;system development#GO:0048731 synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell junction#GO:0030054 structural protein#PC00211 HUMAN|HGNC=9652|UniProtKB=Q9Y2R2 Q9Y2R2 PTPN22 PTHR45983:SF1 TYROSINE PHOSPHATSE N18, PUTATIVE-RELATED TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 22 phosphoprotein phosphatase activity#GO:0004721;protein tyrosine phosphatase activity#GO:0004725;hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096 cell surface receptor signaling pathway#GO:0007166;immune response-activating signaling pathway#GO:0002757;positive regulation of immune system process#GO:0002684;cellular process#GO:0009987;signal transduction#GO:0007165;activation of immune response#GO:0002253;positive regulation of biological process#GO:0048518;regulation of T cell activation#GO:0050863;regulation of response to external stimulus#GO:0032101;negative regulation of cell-cell adhesion#GO:0022408;antigen receptor-mediated signaling pathway#GO:0050851;regulation of multicellular organismal process#GO:0051239;negative regulation of lymphocyte activation#GO:0051250;negative regulation of leukocyte activation#GO:0002695;regulation of intracellular signal transduction#GO:1902531;immune system process#GO:0002376;regulation of signaling#GO:0023051;regulation of non-canonical NF-kappaB signal transduction#GO:1901222;regulation of leukocyte activation#GO:0002694;negative regulation of biological process#GO:0048519;immune response-regulating signaling pathway#GO:0002764;regulation of cell activation#GO:0050865;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of lymphocyte activation#GO:0051249;signaling#GO:0023052;negative regulation of cellular process#GO:0048523;regulation of response to stress#GO:0080134;regulation of leukocyte cell-cell adhesion#GO:1903037;T cell receptor signaling pathway#GO:0050852;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;negative regulation of cell activation#GO:0050866;regulation of innate immune response#GO:0045088;regulation of cell adhesion#GO:0030155;positive regulation of response to stimulus#GO:0048584;negative regulation of cell adhesion#GO:0007162;regulation of signal transduction#GO:0009966;negative regulation of immune system process#GO:0002683;immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007;regulation of defense response#GO:0031347;regulation of immune response#GO:0050776;negative regulation of T cell activation#GO:0050868;cell communication#GO:0007154;negative regulation of multicellular organismal process#GO:0051241;cellular response to stimulus#GO:0051716;regulation of cell-cell adhesion#GO:0022407;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of response to biotic stimulus#GO:0002831;regulation of cell communication#GO:0010646;immune response-activating cell surface receptor signaling pathway#GO:0002429;negative regulation of leukocyte cell-cell adhesion#GO:1903038 nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=338|UniProtKB=P50052 P50052 AGTR2 PTHR24228:SF8 B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR TYPE-2 ANGIOTENSIN II RECEPTOR molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528 regulation of anatomical structure size#GO:0090066;defense response#GO:0006952;system process#GO:0003008;response to stress#GO:0006950;cellular process#GO:0009987;signal transduction#GO:0007165;multicellular organismal process#GO:0032501;blood circulation#GO:0008015;biological regulation#GO:0065007;circulatory system process#GO:0003013;G protein-coupled receptor signaling pathway#GO:0007186;inflammatory response#GO:0006954;cell communication#GO:0007154;regulation of biological quality#GO:0065008;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;vasodilation#GO:0042311;signaling#GO:0023052 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=23792|UniProtKB=Q96BZ4 Q96BZ4 PLD4 PTHR10185:SF8 PHOSPHOLIPASE D - RELATED 5'-3' EXONUCLEASE PLD4 localization#GO:0051179;endocytosis#GO:0006897;establishment of localization#GO:0051234;import into cell#GO:0098657;transport#GO:0006810;phagocytosis#GO:0006909 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 phospholipase#PC00186 HUMAN|HGNC=26756|UniProtKB=Q6UWP7 Q6UWP7 LCLAT1 PTHR10983:SF81 1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED LYSOCARDIOLIPIN ACYLTRANSFERASE 1 catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746 glycerophospholipid metabolic process#GO:0006650;glycerolipid metabolic process#GO:0046486;phospholipid metabolic process#GO:0006644;organophosphate metabolic process#GO:0019637;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;cellular process#GO:0009987;metabolic process#GO:0008152;phosphatidylinositol metabolic process#GO:0046488;lipid metabolic process#GO:0006629 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 transferase#PC00220;acyltransferase#PC00042 HUMAN|HGNC=25102|UniProtKB=Q8NBR0 Q8NBR0 TP53I13 PTHR34179:SF1 TUMOR PROTEIN P53-INDUCIBLE PROTEIN 13 TUMOR PROTEIN P53-INDUCIBLE PROTEIN 13 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=1337|UniProtKB=Q7LBC6 Q7LBC6 KDM3B PTHR12549:SF8 JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROTEIN LYSINE-SPECIFIC DEMETHYLASE 3B demethylase activity#GO:0032451;catalytic activity, acting on a protein#GO:0140096;protein demethylase activity#GO:0140457;chromatin DNA binding#GO:0031490;histone demethylase activity#GO:0032452;catalytic activity#GO:0003824;transcription coregulator activity#GO:0003712;histone modifying activity#GO:0140993;DNA binding#GO:0003677;chromatin binding#GO:0003682;transcription regulator activity#GO:0140110;binding#GO:0005488;nucleic acid binding#GO:0003676 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;chromatin#GO:0000785;chromosome#GO:0005694 histone modifying enzyme#PC00261 HUMAN|HGNC=8664|UniProtKB=Q9Y5I2 Q9Y5I2 PCDHA10 PTHR24028:SF124 CADHERIN-87A PROTOCADHERIN ALPHA-10 cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 cell adhesion molecule#PC00069;cadherin#PC00057 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HUMAN|HGNC=5173|UniProtKB=P01112 P01112 HRAS PTHR24070:SF465 RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY GTPASE HRAS hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787 positive regulation of cell population proliferation#GO:0008284;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;Ras protein signal transduction#GO:0007265;cellular response to stress#GO:0033554;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;intracellular signal transduction#GO:0035556;response to stress#GO:0006950;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of cellular process#GO:0048522;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 small GTPase#PC00208 Ras Pathway#P04393>Ras#P04547;Gonadotropin-releasing hormone receptor pathway#P06664>Ras#P06753;TGF-beta signaling pathway#P00052>Ras-GDP#P01291;EGF receptor signaling pathway#P00018>Ras#P00552;PDGF signaling pathway#P00047>Ras#P01154;VEGF signaling pathway#P00056>Ras#P01411;TGF-beta signaling pathway#P00052>Ras-GTP#P01280;Integrin signalling pathway#P00034>Ras#P00916;Angiogenesis#P00005>Ras#P00238;B cell activation#P00010>Ras#P00376;T cell activation#P00053>Ras#P01306;p53 pathway feedback loops 2#P04398>Ras#P04651;FGF signaling pathway#P00021>Ras#P00633 HUMAN|HGNC=34438|UniProtKB=Q4G0S7 Q4G0S7 CCDC152 PTHR35253:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 152 COILED-COIL DOMAIN-CONTAINING PROTEIN 152 HUMAN|HGNC=21478|UniProtKB=Q8HWS3 Q8HWS3 RFX6 PTHR12619:SF28 RFX TRANSCRIPTION FACTOR FAMILY DNA-BINDING PROTEIN RFX6 binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 chemical homeostasis#GO:0048878;developmental process#GO:0032502;regulation of gene expression#GO:0010468;glucose homeostasis#GO:0042593;animal organ development#GO:0048513;regulation of biosynthetic process#GO:0009889;multicellular organism development#GO:0007275;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;animal gross anatomical part developmental process#GO:0160108;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;pancreas development#GO:0031016;carbohydrate homeostasis#GO:0033500;regulation of biological process#GO:0050789;homeostatic process#GO:0042592;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 winged helix/forkhead transcription factor#PC00246 HUMAN|HGNC=30745|UniProtKB=Q96B18 Q96B18 DACT3 PTHR15919:SF1 DAPPER-RELATED DAPPER HOMOLOG 3 regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;regulation of canonical Wnt signaling pathway#GO:0060828;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of Wnt signaling pathway#GO:0030178;negative regulation of response to stimulus#GO:0048585;regulation of signaling#GO:0023051;negative regulation of canonical Wnt signaling pathway#GO:0090090;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111;regulation of cellular process#GO:0050794 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=10419|UniProtKB=P62273 P62273 RPS29 PTHR12010:SF26 40S RIBOSOMAL PROTEIN S29 SMALL RIBOSOMAL SUBUNIT PROTEIN US14 metal ion binding#GO:0046872;cation binding#GO:0043169;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;transition metal ion binding#GO:0046914;structural molecule activity#GO:0005198;zinc ion binding#GO:0008270;structural constituent of ribosome#GO:0003735 protein biosynthetic process#GO:0160307;gene expression#GO:0010467;cytoplasmic translation#GO:0002181;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;translation#GO:0006412 cytosolic small ribosomal subunit#GO:0022627;ribonucleoprotein complex#GO:1990904;small ribosomal subunit#GO:0015935;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytosolic ribosome#GO:0022626;cytosol#GO:0005829;ribosome#GO:0005840;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391 ribosomal protein#PC00202;translational protein#PC00263 HUMAN|HGNC=7317|UniProtKB=Q96HJ5 Q96HJ5 MS4A3 PTHR23320:SF74 MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 3 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227 HUMAN|HGNC=9991|UniProtKB=Q08116 Q08116 RGS1 PTHR10845:SF34 REGULATOR OF G PROTEIN SIGNALING REGULATOR OF G PROTEIN SIGNALING 1 enzyme activator activity#GO:0008047;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 regulation of biological process#GO:0050789;negative regulation of G protein-coupled receptor signaling pathway#GO:0045744;negative regulation of biological process#GO:0048519;regulation of cell communication#GO:0010646;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of response to stimulus#GO:0048585;regulation of cellular process#GO:0050794;regulation of response to stimulus#GO:0048583;regulation of G protein-coupled receptor signaling pathway#GO:0008277;regulation of signaling#GO:0023051;negative regulation of cellular process#GO:0048523;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648 plasma membrane#GO:0005886;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;cytoplasmic side of membrane#GO:0098562;cytoplasmic side of plasma membrane#GO:0009898;membrane#GO:0016020 GTPase-activating protein#PC00257 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>RGS#P00704;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>RGS#P00833;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>RGS#P00731 HUMAN|HGNC=26528|UniProtKB=Q96M95 Q96M95 CCDC42 PTHR21683:SF8 COILED-COIL DOMAIN-CONTAINING PROTEIN 42 LIKE-2-LIKE-RELATED COILED-COIL DOMAIN-CONTAINING PROTEIN 42 cellular process#GO:0009987;male gamete generation#GO:0048232;spermatogenesis#GO:0007283;developmental process#GO:0032502;cellular developmental process#GO:0048869;germ cell development#GO:0007281;developmental process involved in reproduction#GO:0003006;reproductive process#GO:0022414;cellular process involved in reproduction in multicellular organism#GO:0022412;cell development#GO:0048468;gamete generation#GO:0007276;cell differentiation#GO:0030154;spermatid development#GO:0007286;sexual reproduction#GO:0019953;spermatid differentiation#GO:0048515;multicellular organismal reproductive process#GO:0048609;anatomical structure development#GO:0048856 microtubule or microtubule-binding cytoskeletal protein#PC00157;non-motor microtubule binding protein#PC00166 HUMAN|HGNC=20814|UniProtKB=Q9C0F3 Q9C0F3 ZNF436 PTHR24381:SF434 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 436 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=31304|UniProtKB=A6NL08 A6NL08 OR6C75 PTHR26454:SF79 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 6C75 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=9183|UniProtKB=Q9UBT6 Q9UBT6 POLK PTHR11076:SF33 DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER DNA POLYMERASE KAPPA DNA-directed DNA polymerase activity#GO:0003887;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;DNA polymerase activity#GO:0034061;catalytic activity, acting on DNA#GO:0140097 translesion synthesis#GO:0019985;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;response to stress#GO:0006950;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;DNA biosynthetic process#GO:0071897;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA damage tolerance#GO:0006301;DNA damage response#GO:0006974;response to stimulus#GO:0050896;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;DNA replication#GO:0006260;cellular response to stimulus#GO:0051716;DNA synthesis involved in DNA replication#GO:0090592;nucleic acid biosynthetic process#GO:0141187;cellular response to stress#GO:0033554 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA metabolism protein#PC00009 HUMAN|HGNC=28153|UniProtKB=Q0VDD7 Q0VDD7 BRME1 PTHR14583:SF0 UNCHARACTERIZED PROTEIN C19ORF57 FAMILY MEMBER BREAK REPAIR MEIOTIC RECOMBINASE RECRUITMENT FACTOR 1 HUMAN|HGNC=19343|UniProtKB=Q8NDV1 Q8NDV1 ST6GALNAC3 PTHR45906:SF2 ALPHA-N-ACETYL-NEURAMINYL-2,3-BETA-GALACTOSYL-1, 3-N-ACETYL-GALACTOSAMINIDE ALPHA-2,6-SIALYLTRANSFERASE-LIKE ALPHA-N-ACETYLGALACTOSAMINIDE ALPHA-2,6-SIALYLTRANSFERASE 3 glycosyltransferase activity#GO:0016757;sialyltransferase activity#GO:0008373;catalytic activity#GO:0003824;transferase activity#GO:0016740 oligosaccharide metabolic process#GO:0009311;carbohydrate derivative biosynthetic process#GO:1901137;ceramide biosynthetic process#GO:0046513;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;sphingolipid metabolic process#GO:0006665;sphingolipid biosynthetic process#GO:0030148;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;glycolipid biosynthetic process#GO:0009247;ceramide metabolic process#GO:0006672;glycosphingolipid biosynthetic process#GO:0006688;carbohydrate metabolic process#GO:0005975;liposaccharide metabolic process#GO:1903509;glycolipid metabolic process#GO:0006664;primary metabolic process#GO:0044238 HUMAN|HGNC=50507|UniProtKB=A0A1B0GTU2 A0A1B0GTU2 CTXND1 PTHR16736:SF5 CORTEXIN-1-RELATED CORTEXIN DOMAIN-CONTAINING 1 PROTEIN HUMAN|HGNC=5956|UniProtKB=Q14623 Q14623 IHH PTHR11889:SF39 HEDGEHOG INDIAN HEDGEHOG PROTEIN protein binding#GO:0005515;metal ion binding#GO:0046872;cation binding#GO:0043169;ion binding#GO:0043167;binding#GO:0005488;signaling receptor binding#GO:0005102;small molecule binding#GO:0036094;calcium ion binding#GO:0005509 cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;developmental process#GO:0032502;cell surface receptor signaling pathway#GO:0007166;cell fate specification#GO:0001708;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;signal transduction#GO:0007165;cellular process#GO:0009987;cell communication#GO:0007154;smoothened signaling pathway#GO:0007224;cell fate commitment#GO:0045165;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HUMAN|HGNC=11443|UniProtKB=Q9UNK0 Q9UNK0 STX8 PTHR19957:SF285 SYNTAXIN SYNTAXIN-8 SNAP receptor activity#GO:0005484;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 cellular localization#GO:0051641;localization#GO:0051179;protein transport#GO:0015031;vesicle fusion#GO:0006906;cellular component organization#GO:0016043;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;vesicle organization#GO:0016050;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810;vesicle-mediated transport#GO:0016192;organelle fusion#GO:0048284;organelle membrane fusion#GO:0090174;membrane organization#GO:0061024;membrane fusion#GO:0061025;organelle organization#GO:0006996;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;SNARE complex#GO:0031201;cytoplasm#GO:0005737;membrane#GO:0016020;membrane protein complex#GO:0098796;intracellular anatomical structure#GO:0005622 SNARE protein#PC00034 HUMAN|HGNC=25903|UniProtKB=Q8NBU5 Q8NBU5 ATAD1 PTHR45644:SF2 AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED OUTER MITOCHONDRIAL TRANSMEMBRANE HELIX TRANSLOCASE localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization within membrane#GO:0051668;establishment of protein localization#GO:0045184;cellular process#GO:0009987;establishment of protein localization to membrane#GO:0090150 HUMAN|HGNC=28018|UniProtKB=Q0D2K0 Q0D2K0 NIPAL4 PTHR12570:SF7 DUF803 DOMAIN MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07070)-RELATED MAGNESIUM TRANSPORTER NIPA4 monoatomic ion transport#GO:0006811;metal ion transport#GO:0030001;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;localization#GO:0051179;transport#GO:0006810;magnesium ion transport#GO:0015693 cellular anatomical structure#GO:0110165;membrane#GO:0016020 secondary carrier transporter#PC00258 HUMAN|HGNC=33814|UniProtKB=Q5TCS8 Q5TCS8 AK9 PTHR23359:SF148 NUCLEOTIDE KINASE ADENYLATE KINASE 9 nucleobase-containing compound kinase activity#GO:0019205;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;nucleoside diphosphate kinase activity#GO:0004550;phosphotransferase activity, phosphate group as acceptor#GO:0016776 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 kinase#PC00137;nucleotide kinase#PC00172 HUMAN|HGNC=1171|UniProtKB=Q96EB1 Q96EB1 ELP4 PTHR12896:SF1 PAX6 NEIGHBOR PROTEIN PAXNEB ELONGATOR COMPLEX PROTEIN 4 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;tRNA wobble uridine modification#GO:0002098;tRNA wobble base modification#GO:0002097;tRNA modification#GO:0006400;RNA biosynthetic process#GO:0032774;RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070 elongator holoenzyme complex#GO:0033588;intracellular protein-containing complex#GO:0140535;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494 HUMAN|HGNC=7994|UniProtKB=Q92823 Q92823 NRCAM PTHR10075:SF44 BASIGIN RELATED NEURONAL CELL ADHESION MOLECULE cell adhesion molecule#PC00069 HUMAN|HGNC=4214|UniProtKB=P27539 P27539 GDF1 PTHR11848:SF151 TGF-BETA FAMILY EMBRYONIC GROWTH_DIFFERENTIATION FACTOR 1 molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;cytokine activity#GO:0005125;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018 cellular response to growth factor stimulus#GO:0071363;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;signaling#GO:0023052;response to stimulus#GO:0050896;response to growth factor#GO:0070848;cellular response to endogenous stimulus#GO:0071495;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;BMP signaling pathway#GO:0030509;cellular response to stimulus#GO:0051716;response to endogenous stimulus#GO:0009719;response to BMP#GO:0071772;cellular response to BMP stimulus#GO:0071773;cell surface receptor signaling pathway#GO:0007166;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;biological regulation#GO:0065007;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;signal transduction#GO:0007165;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 growth factor#PC00112 TGF-beta signaling pathway#P00052>TGFbeta#P01286 HUMAN|HGNC=10891|UniProtKB=Q8N196 Q8N196 SIX5 PTHR10390:SF40 HOMEOBOX PROTEIN SIX HOMEOBOX PROTEIN SIX5 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 HUMAN|HGNC=23528|UniProtKB=A7E2V4 A7E2V4 ZSWIM8 PTHR22619:SF1 ZINC FINGER SWIM DOMAIN CONTAINING PROTEIN 4, 5, 6 ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 8 ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461;Cul2-RING ubiquitin ligase complex#GO:0031462;catalytic complex#GO:1902494;transferase complex#GO:1990234 HUMAN|HGNC=12637|UniProtKB=O15550 O15550 KDM6A PTHR14017:SF9 LYSINE-SPECIFIC DEMETHYLASE LYSINE-SPECIFIC DEMETHYLASE 6A chromatin DNA binding#GO:0031490;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;oxidoreductase activity#GO:0016491;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;chromatin binding#GO:0003682;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;dioxygenase activity#GO:0051213;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;histone demethylase activity#GO:0032452;sequence-specific DNA binding#GO:0043565;protein demethylase activity#GO:0140457;demethylase activity#GO:0032451;binding#GO:0005488;histone modifying activity#GO:0140993;transcription regulatory region nucleic acid binding#GO:0001067 circulatory system development#GO:0072359;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;system development#GO:0048731;anatomical structure development#GO:0048856;animal gross anatomical part developmental process#GO:0160108;biological regulation#GO:0065007;heart development#GO:0007507;multicellular organismal process#GO:0032501;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;multicellular organism development#GO:0007275;regulation of biosynthetic process#GO:0009889;animal organ development#GO:0048513;developmental process#GO:0032502 transferase complex#GO:1990234;histone methyltransferase complex#GO:0035097;nuclear protein-containing complex#GO:0140513;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular organelle lumen#GO:0070013;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;methyltransferase complex#GO:0034708;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=20349|UniProtKB=Q63HM2 Q63HM2 PCNX4 PTHR12372:SF6 PECANEX PECANEX-LIKE PROTEIN 4 HUMAN|HGNC=24477|UniProtKB=Q9NQZ2 Q9NQZ2 UTP3 PTHR13237:SF8 SOMETHING ABOUT SILENCING PROTEIN 10-RELATED SOMETHING ABOUT SILENCING PROTEIN 10 macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;ribosomal small subunit biogenesis#GO:0042274;gene expression#GO:0010467;maturation of SSU-rRNA#GO:0030490;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;small-subunit processome#GO:0032040;organelle lumen#GO:0043233;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;preribosome#GO:0030684;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904 RNA metabolism protein#PC00031 HUMAN|HGNC=24040|UniProtKB=Q96A54 Q96A54 ADIPOR1 PTHR20855:SF40 ADIPOR/PROGESTIN RECEPTOR-RELATED ADIPONECTIN RECEPTOR PROTEIN 1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 response to hormone#GO:0009725;cellular process#GO:0009987;signal transduction#GO:0007165;response to cytokine#GO:0034097;response to chemical#GO:0042221;biological regulation#GO:0065007;cell surface receptor signaling pathway#GO:0007166;response to endogenous stimulus#GO:0009719;cellular response to stimulus#GO:0051716;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;cellular response to hormone stimulus#GO:0032870;regulation of cellular process#GO:0050794;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;signaling#GO:0023052;cytokine-mediated signaling pathway#GO:0019221;cellular response to chemical stimulus#GO:0070887;hormone-mediated signaling pathway#GO:0009755;cell communication#GO:0007154;response to peptide#GO:1901652 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 Gonadotropin-releasing hormone receptor pathway#P06664>AdipoR1/R2#P06706 HUMAN|HGNC=40813|UniProtKB=Q1RN00 Q1RN00 NECTIN3-AS1 PTHR40143:SF1 FAMILY NOT NAMED SUBFAMILY NOT NAMED HUMAN|HGNC=19957|UniProtKB=O15040 O15040 TECPR2 PTHR23287:SF16 RUBY-EYE2-LIKE PROTEIN TECTONIN BETA-PROPELLER REPEAT-CONTAINING PROTEIN 2 HUMAN|HGNC=2033|UniProtKB=P78369 P78369 CLDN10 PTHR12002:SF13 CLAUDIN CLAUDIN-10 paracellular tight junction channel activity#GO:0160187;transporter activity#GO:0005215 cell-cell junction organization#GO:0045216;cell-cell junction assembly#GO:0007043;transport#GO:0006810;cellular component organization or biogenesis#GO:0071840;paracellular transport#GO:0160184;localization#GO:0051179;establishment of localization#GO:0051234;cellular process#GO:0009987;cell junction assembly#GO:0034329;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;cellular component assembly#GO:0022607;cell junction organization#GO:0034330 cell periphery#GO:0071944;membrane#GO:0016020;cell-cell junction#GO:0005911;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;bicellular tight junction#GO:0005923;apical junction complex#GO:0043296;anchoring junction#GO:0070161;tight junction#GO:0070160;cell junction#GO:0030054 cell junction protein#PC00070;tight junction#PC00214 HUMAN|HGNC=4565|UniProtKB=Q14449 Q14449 GRB14 PTHR11243:SF22 GROWTH FACTOR RECEPTOR-BOUND PROTEIN GROWTH FACTOR RECEPTOR-BOUND PROTEIN 14 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 response to hormone#GO:0009725;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;cellular process#GO:0009987;response to chemical#GO:0042221;negative regulation of signal transduction#GO:0009968;cell surface receptor signaling pathway#GO:0007166;response to endogenous stimulus#GO:0009719;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;cellular response to hormone stimulus#GO:0032870;signaling#GO:0023052;cellular response to chemical stimulus#GO:0070887;negative regulation of signaling#GO:0023057;response to oxygen-containing compound#GO:1901700;insulin receptor signaling pathway#GO:0008286;regulation of signaling#GO:0023051;negative regulation of cell communication#GO:0010648;cellular response to nitrogen compound#GO:1901699;negative regulation of response to stimulus#GO:0048585;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;response to peptide hormone#GO:0043434;negative regulation of cellular process#GO:0048523;cellular response to insulin stimulus#GO:0032869;regulation of response to stimulus#GO:0048583;cellular response to stimulus#GO:0051716;response to insulin#GO:0032868;regulation of cellular process#GO:0050794;cellular response to peptide hormone stimulus#GO:0071375;regulation of cell communication#GO:0010646;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;response to nitrogen compound#GO:1901698;intracellular signal transduction#GO:0035556 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 scaffold/adaptor protein#PC00226 Angiogenesis#P00005>Grb14#P00197 HUMAN|HGNC=22969|UniProtKB=P60370 P60370 KRTAP10-5 PTHR23262:SF206 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 10-1-RELATED structural protein#PC00211 HUMAN|HGNC=35645|UniProtKB=A6NKH3 A6NKH3 RPL37AP8 PTHR48188:SF6 60S RIBOSOMAL PROTEIN L43 RIBOSOMAL PROTEIN EL43-LIKE-RELATED intracellular organelle#GO:0043229;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;ribosome#GO:0005840;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625;cytosol#GO:0005829;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226 translational protein#PC00263;ribosomal protein#PC00202 HUMAN|HGNC=3508|UniProtKB=Q01844 Q01844 EWSR1 PTHR23238:SF3 RNA BINDING PROTEIN RNA-BINDING PROTEIN EWS RNA binding#GO:0003723;transcription coregulator activity#GO:0003712;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription regulator activity#GO:0140110 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 RNA metabolism protein#PC00031 HUMAN|HGNC=27610|UniProtKB=Q6P5R6 Q6P5R6 RPL22L1 PTHR10064:SF1 60S RIBOSOMAL PROTEIN L22 RIBOSOMAL PROTEIN EL22-LIKE binding#GO:0005488;structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;structural molecule activity#GO:0005198 metabolic process#GO:0008152;translation#GO:0006412;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cytoplasmic translation#GO:0002181;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;biosynthetic process#GO:0009058 ribosomal protein#PC00202 HUMAN|HGNC=13380|UniProtKB=Q9BY19 Q9BY19 MS4A8 PTHR23320:SF155 MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 8 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227 HUMAN|HGNC=26845|UniProtKB=Q8N819 Q8N819 PPM1N PTHR47992:SF59 PROTEIN PHOSPHATASE PROTEIN PHOSPHATASE 1N-RELATED protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824 positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of canonical NF-kappaB signal transduction#GO:0043122;regulation of canonical Wnt signaling pathway#GO:0060828;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of Wnt signaling pathway#GO:0030177;positive regulation of response to stimulus#GO:0048584;regulation of response to stimulus#GO:0048583;positive regulation of canonical Wnt signaling pathway#GO:0090263;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;positive regulation of signaling#GO:0023056 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cytosol#GO:0005829;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HUMAN|HGNC=31677|UniProtKB=Q6IWH7 Q6IWH7 ANO7 PTHR12308:SF22 ANOCTAMIN ANOCTAMIN-7 transporter activity#GO:0005215;phospholipid scramblase activity#GO:0017128;lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104;intramembrane lipid carrier activity#GO:0140303 lipid localization#GO:0010876;regulation of biological quality#GO:0065008;plasma membrane organization#GO:0007009;localization#GO:0051179;cellular component organization#GO:0016043;plasma membrane phospholipid scrambling#GO:0017121;lipid translocation#GO:0034204;organophosphate ester transport#GO:0015748;transport#GO:0006810;regulation of membrane lipid distribution#GO:0097035;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;cellular process#GO:0009987;macromolecule localization#GO:0033036;phospholipid transport#GO:0015914;membrane organization#GO:0061024;biological regulation#GO:0065007;endomembrane system organization#GO:0010256;phospholipid translocation#GO:0045332;lipid transport#GO:0006869 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=9448|UniProtKB=P04554 P04554 PRM2 PTHR21341:SF2 PROTAMINE-2 PROTAMINE-2 male gamete generation#GO:0048232;organelle organization#GO:0006996;cellular process#GO:0009987;cellular developmental process#GO:0048869;nucleus organization#GO:0006997;cellular component organization or biogenesis#GO:0071840;spermatogenesis#GO:0007283;developmental process#GO:0032502;gamete generation#GO:0007276;cell differentiation#GO:0030154;cell development#GO:0048468;cellular process involved in reproduction in multicellular organism#GO:0022412;reproductive process#GO:0022414;developmental process involved in reproduction#GO:0003006;cellular component organization#GO:0016043;germ cell development#GO:0007281;anatomical structure development#GO:0048856;multicellular organismal reproductive process#GO:0048609;spermatid differentiation#GO:0048515;spermatid development#GO:0007286;sexual reproduction#GO:0019953 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=20184|UniProtKB=Q9P055 Q9P055 JKAMP PTHR12740:SF4 JNK1/MAPK8-ASSOCIATED MEMBRANE PROTEIN JNK1_MAPK8-ASSOCIATED MEMBRANE PROTEIN binding#GO:0005488;ubiquitin-like protein ligase binding#GO:0044389;enzyme binding#GO:0019899;protein binding#GO:0005515;ubiquitin protein ligase binding#GO:0031625 cellular process#GO:0009987;response to stress#GO:0006950;proteasomal protein catabolic process#GO:0010498;response to chemical#GO:0042221;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;catabolic process#GO:0009056;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;response to endoplasmic reticulum stress#GO:0034976;ERAD pathway#GO:0036503;protein metabolic process#GO:0019538 scaffold/adaptor protein#PC00226 HUMAN|HGNC=41978|UniProtKB=F8WFD2 F8WFD2 NPIPA3 PTHR15438:SF5 NUCLEAR PORE COMPLEX INTERACTING PROTEIN NUCLEAR PORE COMPLEX INTERACTING PROTEIN FAMILY MEMBER B3-RELATED HUMAN|HGNC=14985|UniProtKB=Q86V48 Q86V48 LUZP1 PTHR23166:SF7 FILAMIN/GPBP-INTERACTING PROTEIN LEUCINE ZIPPER PROTEIN 1 intracellular protein localization#GO:0008104;protein localization to organelle#GO:0033365;localization#GO:0051179;protein localization to cytoskeleton#GO:0044380;macromolecule localization#GO:0033036 intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microtubule cytoskeleton#GO:0015630;actin cytoskeleton#GO:0015629;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;centrosome#GO:0005813;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856 HUMAN|HGNC=13099|UniProtKB=P13682 P13682 ZNF35 PTHR24381:SF60 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 35 double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=6287|UniProtKB=Q9NPA1 Q9NPA1 KCNMB3 PTHR10258:SF4 CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA-3 molecular function regulator activity#GO:0098772;channel regulator activity#GO:0016247;potassium channel regulator activity#GO:0015459;transporter regulator activity#GO:0141108;ion channel regulator activity#GO:0099106 detection of chemical stimulus#GO:0009593;action potential#GO:0001508;response to stimulus#GO:0050896;metal ion transport#GO:0030001;nervous system process#GO:0050877;monoatomic cation transport#GO:0006812;cell communication#GO:0007154;response to calcium ion#GO:0051592;localization#GO:0051179;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;detection of stimulus#GO:0051606;cellular process#GO:0009987;multicellular organismal process#GO:0032501;potassium ion transport#GO:0006813;response to chemical#GO:0042221;biological regulation#GO:0065007;transport#GO:0006810;response to metal ion#GO:0010038;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;system process#GO:0003008;transmission of nerve impulse#GO:0019226 transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;cation channel complex#GO:0034703;voltage-gated potassium channel complex#GO:0008076;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944 ion channel#PC00133;voltage-gated ion channel#PC00241 HUMAN|HGNC=5411|UniProtKB=O14879 O14879 IFIT3 PTHR10271:SF3 INTERFERON-INDUCED PROTEIN WITH TETRATRICOPEPTIDE REPEATS INTERFERON-INDUCED PROTEIN WITH TETRATRICOPEPTIDE REPEATS 3 binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 response to virus#GO:0009615;response to peptide#GO:1901652;immune system process#GO:0002376;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;defense response to virus#GO:0051607;cellular response to cytokine stimulus#GO:0071345;antiviral innate immune response#GO:0140374;innate immune response#GO:0045087;response to external stimulus#GO:0009605;defense response#GO:0006952;response to chemical#GO:0042221;response to cytokine#GO:0034097;defense response to other organism#GO:0098542;response to other organism#GO:0051707;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;immune response#GO:0006955;defense response to symbiont#GO:0140546 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 defense/immunity protein#PC00090 HUMAN|HGNC=23160|UniProtKB=Q96F10 Q96F10 SAT2 PTHR10545:SF51 DIAMINE N-ACETYLTRANSFERASE THIALYSINE N-EPSILON-ACETYLTRANSFERASE acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740;acetyltransferase activity#GO:0016407;N-acetyltransferase activity#GO:0008080;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 transferase#PC00220;acetyltransferase#PC00038 HUMAN|HGNC=346|UniProtKB=A9YTQ3 A9YTQ3 AHRR PTHR10649:SF3 ARYL HYDROCARBON RECEPTOR ARYL HYDROCARBON RECEPTOR REPRESSOR sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;nuclear receptor activity#GO:0004879;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794 nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;signaling receptor complex#GO:0043235;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=17383|UniProtKB=Q9H3N8 Q9H3N8 HRH4 PTHR24247:SF199 5-HYDROXYTRYPTAMINE RECEPTOR HISTAMINE H4 RECEPTOR acetylcholine receptor activity#GO:0015464;transmembrane signaling receptor activity#GO:0004888;postsynaptic neurotransmitter receptor activity#GO:0098960;molecular transducer activity#GO:0060089;neurotransmitter receptor activity#GO:0030594;G protein-coupled amine receptor activity#GO:0008227;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023 response to chemical#GO:0042221;acetylcholine receptor signaling pathway#GO:0095500;cellular response to nitrogen compound#GO:1901699;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;synaptic signaling#GO:0099536;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987;adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway#GO:0007193;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;anterograde trans-synaptic signaling#GO:0098916;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;response to nitrogen compound#GO:1901698;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;trans-synaptic signaling#GO:0099537;response to oxygen-containing compound#GO:1901700 plasma membrane bounded cell projection#GO:0120025;somatodendritic compartment#GO:0036477;cell projection#GO:0042995;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;synapse#GO:0045202;cell periphery#GO:0071944;neuron projection#GO:0043005;membrane#GO:0016020;cell junction#GO:0030054;dendritic tree#GO:0097447;dendrite#GO:0030425 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GsPCR#P00720 HUMAN|HGNC=23925|UniProtKB=O43310 O43310 CTIF PTHR23254:SF16 EIF4G DOMAIN PROTEIN CBP80_20-DEPENDENT TRANSLATION INITIATION FACTOR translation regulator activity#GO:0045182 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;regulation of protein metabolic process#GO:0051246;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of translational initiation#GO:0006446;post-transcriptional regulation of gene expression#GO:0010608;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 RNA metabolism protein#PC00031 HUMAN|HGNC=7103|UniProtKB=P30301 P30301 MIP PTHR19139:SF39 AQUAPORIN TRANSPORTER LENS FIBER MAJOR INTRINSIC PROTEIN water channel activity#GO:0015250;water transmembrane transporter activity#GO:0005372;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;passive transmembrane transporter activity#GO:0022803;channel activity#GO:0015267 transport#GO:0006810;fluid transport#GO:0042044;establishment of localization#GO:0051234;water transport#GO:0006833;localization#GO:0051179 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227 HUMAN|HGNC=24738|UniProtKB=Q96MH7 Q96MH7 C5orf34 PTHR34531:SF1 ZGC:153352 CHROMOSOME 5 OPEN READING FRAME 34 HUMAN|HGNC=6774|UniProtKB=O15198 O15198 SMAD9 PTHR13703:SF41 SMAD SMAD FAMILY MEMBER 9 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;protein binding#GO:0005515 cellular response to BMP stimulus#GO:0071773;cell surface receptor signaling pathway#GO:0007166;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;intracellular signaling cassette#GO:0141124;transforming growth factor beta receptor signaling pathway#GO:0007179;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to growth factor stimulus#GO:0071363;cell differentiation#GO:0030154;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;signaling#GO:0023052;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;developmental process#GO:0032502;response to BMP#GO:0071772;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;cell communication#GO:0007154;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;enzyme-linked receptor protein signaling pathway#GO:0007167;intracellular signal transduction#GO:0035556;regulation of RNA metabolic process#GO:0051252;response to transforming growth factor beta#GO:0071559;regulation of macromolecule metabolic process#GO:0060255;response to growth factor#GO:0070848;regulation of cellular process#GO:0050794;BMP signaling pathway#GO:0030509;cellular response to transforming growth factor beta stimulus#GO:0071560;cellular response to stimulus#GO:0051716 intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 TGF-beta signaling pathway#P00052>RSmads#P01292;Gonadotropin-releasing hormone receptor pathway#P06664>SMAD1/5/8#P06787;Gonadotropin-releasing hormone receptor pathway#P06664>SMAD2-4#P06819 HUMAN|HGNC=10856|UniProtKB=P14410 P14410 SI PTHR22762:SF66 ALPHA-GLUCOSIDASE SUCRASE-ISOMALTASE, INTESTINAL alpha-glucosidase activity#GO:0090599;hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;catalytic activity#GO:0003824;glucosidase activity#GO:0015926;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553 glucosidase#PC00108 HUMAN|HGNC=10914|UniProtKB=Q9UHW9 Q9UHW9 SLC12A6 PTHR11827:SF66 SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS SOLUTE CARRIER FAMILY 12 MEMBER 6 secondary active transmembrane transporter activity#GO:0015291;monoatomic anion transmembrane transporter activity#GO:0008509;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;chloride transmembrane transporter activity#GO:0015108;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873;solute:monoatomic cation symporter activity#GO:0015294;monoatomic ion transmembrane transporter activity#GO:0015075;symporter activity#GO:0015293;monoatomic cation transmembrane transporter activity#GO:0008324;potassium ion transmembrane transporter activity#GO:0015079 monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;localization#GO:0051179;transport#GO:0006810;chloride transport#GO:0006821;monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;potassium ion transport#GO:0006813;cellular process#GO:0009987;monoatomic anion transport#GO:0006820 apical plasma membrane#GO:0016324;membrane#GO:0016020;apical part of cell#GO:0045177;cell periphery#GO:0071944;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 secondary carrier transporter#PC00258 HUMAN|HGNC=24104|UniProtKB=Q96HD9 Q96HD9 ACY3 PTHR15162:SF5 ASPARTOACYLASE N-ACYL-AROMATIC-L-AMINO ACID AMIDOHYDROLASE (CARBOXYLATE-FORMING) catalytic activity#GO:0003824;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity#GO:0016787 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|Gene=HERVK_113|UniProtKB=Q902F9 Q902F9 HERVK_113 PTHR34313:SF3 ENDOGENOUS RETROVIRUS GROUP K MEMBER 113 ENV POLYPROTEIN-RELATED ENDOGENOUS RETROVIRUS GROUP K MEMBER 113 ENV POLYPROTEIN-RELATED viral or transposable element protein#PC00237 HUMAN|HGNC=27089|UniProtKB=Q6F5E8 Q6F5E8 CARMIL2 PTHR24112:SF32 LEUCINE-RICH REPEAT, ISOFORM F-RELATED CAPPING PROTEIN, ARP2_3 AND MYOSIN-I LINKER PROTEIN 2 regulation of actin filament organization#GO:0110053;cellular process#GO:0009987;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of supramolecular fiber organization#GO:1902903;regulation of actin cytoskeleton organization#GO:0032956;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;cell motility#GO:0048870;cell migration#GO:0016477;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;regulation of actin filament-based process#GO:0032970;regulation of actin nucleation#GO:0051125 plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;lamellipodium#GO:0030027;cell periphery#GO:0071944;membrane#GO:0016020;cell leading edge#GO:0031252 protein-binding activity modulator#PC00095 HUMAN|HGNC=3316|UniProtKB=P32519 P32519 ELF1 PTHR11849:SF156 ETS ETS-RELATED TRANSCRIPTION FACTOR ELF-1 transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;cellular process#GO:0009987;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;developmental process#GO:0032502 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 DNA-binding transcription factor#PC00218;winged helix/forkhead transcription factor#PC00246 PDGF signaling pathway#P00047>Ets#P01167 HUMAN|HGNC=44159|UniProtKB=P0DKB5 P0DKB5 TPBGL PTHR24364:SF16 LP06937P TROPHOBLAST GLYCOPROTEIN-LIKE negative regulation of cell communication#GO:0010648;negative regulation of canonical Wnt signaling pathway#GO:0090090;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;regulation of cellular process#GO:0050794;regulation of Wnt signaling pathway#GO:0030111;regulation of cell communication#GO:0010646;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;negative regulation of response to stimulus#GO:0048585;negative regulation of Wnt signaling pathway#GO:0030178;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of canonical Wnt signaling pathway#GO:0060828 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=1083|UniProtKB=Q12982 Q12982 BNIP2 PTHR12112:SF12 BNIP - RELATED BCL2_ADENOVIRUS E1B 19 KDA PROTEIN-INTERACTING PROTEIN 2 programmed cell death#GO:0012501;apoptotic process#GO:0006915;cell death#GO:0008219;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 hydrolase#PC00121;metabolite interconversion enzyme#PC00262;phosphodiesterase#PC00185 HUMAN|HGNC=5102|UniProtKB=P31271 P31271 HOXA13 PTHR45804:SF3 SEGMENTATION PROTEIN FUSHI TARAZU-LIKE PROTEIN HOMEOBOX PROTEIN HOX-A13 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=11172|UniProtKB=Q13596 Q13596 SNX1 PTHR10555:SF129 SORTING NEXIN SORTING NEXIN-1 ion binding#GO:0043167;phosphatidylinositol binding#GO:0035091;anion binding#GO:0043168;small molecule binding#GO:0036094;binding#GO:0005488 cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;endosomal transport#GO:0016197;intracellular transport#GO:0046907;transport#GO:0006810;vesicle-mediated transport#GO:0016192;cytosolic transport#GO:0016482;retrograde transport, endosome to Golgi#GO:0042147;cellular process#GO:0009987;establishment of localization in cell#GO:0051649 endosome#GO:0005768;endosome membrane#GO:0010008;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;vesicle#GO:0031982;retromer complex#GO:0030904;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane#GO:0016020;vesicle membrane#GO:0012506;cytoplasm#GO:0005737;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659 scaffold/adaptor protein#PC00226 HUMAN|HGNC=18757|UniProtKB=O94955 O94955 RHOBTB3 PTHR24413:SF239 SPECKLE-TYPE POZ PROTEIN RHO-RELATED BTB DOMAIN-CONTAINING PROTEIN 3 protein binding#GO:0005515;ubiquitin protein ligase binding#GO:0031625;binding#GO:0005488;ubiquitin-like protein ligase binding#GO:0044389;enzyme binding#GO:0019899 protein metabolic process#GO:0019538;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;modification-dependent protein catabolic process#GO:0019941;regulation of biological process#GO:0050789;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;regulation of proteolysis#GO:0030162;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;proteasomal protein catabolic process#GO:0010498;biological regulation#GO:0065007;cellular process#GO:0009987;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=11592|UniProtKB=O43435 O43435 TBX1 PTHR11267:SF104 T-BOX PROTEIN-RELATED T-BOX TRANSCRIPTION FACTOR TBX1 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 cellular process#GO:0009987;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;cell fate specification#GO:0001708;developmental process#GO:0032502;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of RNA metabolic process#GO:0051252;cell fate commitment#GO:0045165;regulation of DNA-templated transcription#GO:0006355 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;nucleus#GO:0005634;chromatin#GO:0000785;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 Rel homology transcription factor#PC00252;immunoglobulin fold transcription factor#PC00251 HUMAN|HGNC=29590|UniProtKB=Q7Z7A3 Q7Z7A3 CTU1 PTHR11807:SF12 ATPASES OF THE PP SUPERFAMILY-RELATED CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 1 binding#GO:0005488;nucleic acid binding#GO:0003676;tRNA binding#GO:0000049;RNA binding#GO:0003723 tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;tRNA thio-modification#GO:0034227;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;tRNA wobble uridine modification#GO:0002098;tRNA wobble base modification#GO:0002097;tRNA wobble position uridine thiolation#GO:0002143;tRNA modification#GO:0006400;RNA biosynthetic process#GO:0032774 intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;transferase complex#GO:1990234;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;sulfurtransferase complex#GO:1990228;cytoplasm#GO:0005737;cytosol#GO:0005829 HUMAN|HGNC=10647|UniProtKB=P78423 P78423 CX3CL1 PTHR12015:SF92 SMALL INDUCIBLE CYTOKINE A FRACTALKINE signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;chemokine activity#GO:0008009;G protein-coupled receptor binding#GO:0001664;protein binding#GO:0005515;chemokine receptor binding#GO:0042379;molecular function activator activity#GO:0140677;binding#GO:0005488;signaling receptor binding#GO:0005102;cytokine receptor binding#GO:0005126;cytokine activity#GO:0005125 cellular response to stimulus#GO:0051716;cell motility#GO:0048870;regulation of cellular process#GO:0050794;locomotion#GO:0040011;cellular response to chemokine#GO:1990869;response to external biotic stimulus#GO:0043207;cytokine-mediated signaling pathway#GO:0019221;inflammatory response#GO:0006954;chemotaxis#GO:0006935;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;cell communication#GO:0007154;regulation of cell motility#GO:2000145;chemokine-mediated signaling pathway#GO:0070098;cell chemotaxis#GO:0060326;positive regulation of cell migration#GO:0030335;positive regulation of cellular process#GO:0048522;immune response#GO:0006955;cell migration#GO:0016477;response to other organism#GO:0051707;regulation of locomotion#GO:0040012;biological regulation#GO:0065007;leukocyte migration#GO:0050900;regulation of cell migration#GO:0030334;defense response#GO:0006952;leukocyte chemotaxis#GO:0030595;positive regulation of locomotion#GO:0040017;response to external stimulus#GO:0009605;myeloid leukocyte migration#GO:0097529;positive regulation of cell motility#GO:2000147;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;response to stimulus#GO:0050896;granulocyte chemotaxis#GO:0071621;biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052;immune system process#GO:0002376;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;response to peptide#GO:1901652;response to stress#GO:0006950;response to chemokine#GO:1990868;response to biotic stimulus#GO:0009607;cellular process#GO:0009987;signal transduction#GO:0007165;defense response to symbiont#GO:0140546;positive regulation of biological process#GO:0048518;defense response to other organism#GO:0098542;granulocyte migration#GO:0097530;response to chemical#GO:0042221;taxis#GO:0042330;response to cytokine#GO:0034097;antimicrobial humoral response#GO:0019730;humoral immune response#GO:0006959;cell surface receptor signaling pathway#GO:0007166 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 cytokine#PC00083 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CHK#P00856 HUMAN|HGNC=7605|UniProtKB=Q9UM54 Q9UM54 MYO6 PTHR13140:SF745 MYOSIN UNCONVENTIONAL MYOSIN-VI microfilament motor activity#GO:0000146;catalytic activity#GO:0003824;polypeptide conformation or assembly isomerase activity#GO:0120544;ATP-dependent activity#GO:0140657;macromolecular conformation isomerase activity#GO:0120543;cytoskeletal motor activity#GO:0003774;isomerase activity#GO:0016853 nervous system development#GO:0007399;embryo development#GO:0009790;cytoskeleton organization#GO:0007010;hair cell differentiation#GO:0035315;inner ear morphogenesis#GO:0042472;organelle organization#GO:0006996;cellular process#GO:0009987;animal organ development#GO:0048513;embryonic morphogenesis#GO:0048598;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;neuron differentiation#GO:0030182;sensory organ morphogenesis#GO:0090596;cell differentiation#GO:0030154;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;ear development#GO:0043583;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;epithelial cell differentiation#GO:0030855;tissue development#GO:0009888;multicellular organismal process#GO:0032501;epidermal cell differentiation#GO:0009913;epithelium development#GO:0060429;inner ear development#GO:0048839;actin filament-based movement#GO:0030048;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;actin filament organization#GO:0007015;epidermis development#GO:0008544;sensory organ development#GO:0007423;developmental process#GO:0032502;actin cytoskeleton organization#GO:0030036;animal organ morphogenesis#GO:0009887;anatomical structure development#GO:0048856;system development#GO:0048731;supramolecular fiber organization#GO:0097435;actin filament-based process#GO:0030029;embryonic organ development#GO:0048568 cell periphery#GO:0071944;cell leading edge#GO:0031252;membrane#GO:0016020;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;cytoplasm#GO:0005737;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;ruffle#GO:0001726;vesicle#GO:0031982;intracellular vesicle#GO:0097708;actin cytoskeleton#GO:0015629;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endocytic vesicle#GO:0030139;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410 actin binding motor protein#PC00040 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HUMAN|HGNC=9691|UniProtKB=Q9NZH5 Q9NZH5 PTTG2 PTHR10418:SF8 SECURIN-3 SECURIN-2 endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772;enzyme inhibitor activity#GO:0004857;enzyme regulator activity#GO:0030234;cysteine-type endopeptidase inhibitor activity#GO:0004869;molecular function inhibitor activity#GO:0140678;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;peptidase regulator activity#GO:0061134 nuclear chromosome segregation#GO:0098813;meiotic cell cycle process#GO:1903046;meiosis I#GO:0007127;cellular component organization#GO:0016043;cell cycle#GO:0007049;cell cycle process#GO:0022402;reproductive process#GO:0022414;nuclear division#GO:0000280;meiosis I cell cycle process#GO:0061982;sexual reproduction#GO:0019953;organelle fission#GO:0048285;organelle organization#GO:0006996;cellular process#GO:0009987;meiotic cell cycle#GO:0051321;chromosome segregation#GO:0007059;meiotic nuclear division#GO:0140013;cellular component organization or biogenesis#GO:0071840;homologous chromosome segregation#GO:0045143;meiotic chromosome segregation#GO:0045132 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=10847|UniProtKB=P57775 P57775 FBXW4 PTHR14381:SF1 DACTYLIN F-BOX_WD REPEAT-CONTAINING PROTEIN 4 enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 protein metabolic process#GO:0019538;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;response to stimulus#GO:0050896;catabolic process#GO:0009056;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;DNA damage response#GO:0006974;proteasomal protein catabolic process#GO:0010498;response to stress#GO:0006950;cellular process#GO:0009987 cullin-RING ubiquitin ligase complex#GO:0031461;SCF ubiquitin ligase complex#GO:0019005;intracellular protein-containing complex#GO:0140535;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;transferase complex#GO:1990234 HUMAN|HGNC=12462|UniProtKB=P57075 P57075 UBASH3A PTHR16469:SF7 UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING PROTEIN A negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;negative regulation of signaling#GO:0023057;regulation of immune response#GO:0050776;regulation of signaling#GO:0023051;negative regulation of cell communication#GO:0010648;negative regulation of response to stimulus#GO:0048585;biological regulation#GO:0065007;negative regulation of immune system process#GO:0002683;regulation of signal transduction#GO:0009966;negative regulation of signal transduction#GO:0009968;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=15036|UniProtKB=Q8NGX9 Q8NGX9 OR6P1 PTHR26453:SF73 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 6P1 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 response to stimulus#GO:0050896;response to chemical#GO:0042221;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;detection of chemical stimulus#GO:0009593;system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception#GO:0007600;nervous system process#GO:0050877 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=20157|UniProtKB=Q9ULT8 Q9ULT8 HECTD1 PTHR45670:SF1 E3 UBIQUITIN-PROTEIN LIGASE TRIP12 E3 UBIQUITIN-PROTEIN LIGASE HECTD1 transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659 catabolic process#GO:0009056;modification-dependent protein catabolic process#GO:0019941;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;protein modification process#GO:0036211;primary metabolic process#GO:0044238;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein modification by small protein conjugation or removal#GO:0070647;post-translational protein modification#GO:0043687;proteasomal protein catabolic process#GO:0010498;protein ubiquitination#GO:0016567;cellular process#GO:0009987;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=15389|UniProtKB=Q8NGA6 Q8NGA6 OR10H5 PTHR26453:SF712 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 10H1-RELATED olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 system process#GO:0003008;sensory perception#GO:0007600;nervous system process#GO:0050877;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;response to stimulus#GO:0050896;response to chemical#GO:0042221;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;detection of chemical stimulus#GO:0009593;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=5186|UniProtKB=P55345 P55345 PRMT2 PTHR11006:SF92 PROTEIN ARGININE N-METHYLTRANSFERASE PROTEIN ARGININE N-METHYLTRANSFERASE 2 histone modifying activity#GO:0140993;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;histone methyltransferase activity#GO:0042054;N-methyltransferase activity#GO:0008170;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring one-carbon groups#GO:0016741;protein methyltransferase activity#GO:0008276 regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;chromatin remodeling#GO:0006338;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;chromatin organization#GO:0006325;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 protein modifying enzyme#PC00260 HUMAN|HGNC=4532|UniProtKB=Q9BXC0 Q9BXC0 HCAR1 PTHR46048:SF3 HYDROXYCARBOXYLIC ACID RECEPTOR 2 HYDROXYCARBOXYLIC ACID RECEPTOR 1 G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=28395|UniProtKB=Q8NHU3 Q8NHU3 SGMS2 PTHR21290:SF24 SPHINGOMYELIN SYNTHETASE PHOSPHATIDYLCHOLINE:CERAMIDE CHOLINEPHOSPHOTRANSFERASE 2 phosphotransferase activity, for other substituted phosphate groups#GO:0016780;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824 lipid metabolic process#GO:0006629;ceramide biosynthetic process#GO:0046513;sphingolipid biosynthetic process#GO:0030148;metabolic process#GO:0008152;sphingolipid metabolic process#GO:0006665;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;sphingomyelin metabolic process#GO:0006684;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;ceramide metabolic process#GO:0006672;organophosphate biosynthetic process#GO:0090407;phospholipid metabolic process#GO:0006644;phospholipid biosynthetic process#GO:0008654;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793 endoplasmic reticulum membrane#GO:0005789;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;endoplasmic reticulum#GO:0005783;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane#GO:0016020;cell periphery#GO:0071944;endomembrane system#GO:0012505;cytoplasm#GO:0005737;plasma membrane#GO:0005886;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=594|UniProtKB=Q9BZZ5 Q9BZZ5 API5 PTHR12758:SF23 APOPTOSIS INHIBITOR 5-RELATED APOPTOSIS INHIBITOR 5 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 negative regulation of apoptotic process#GO:0043066;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;negative regulation of programmed cell death#GO:0043069;regulation of biological process#GO:0050789;negative regulation of cellular process#GO:0048523;regulation of apoptotic process#GO:0042981 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=11193|UniProtKB=O95416 O95416 SOX14 PTHR10270:SF107 SOX TRANSCRIPTION FACTOR TRANSCRIPTION FACTOR SOX-14 RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;DNA-binding transcription activator activity#GO:0001216;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228 anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;positive regulation of DNA-templated transcription#GO:0045893;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;brain development#GO:0007420;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;positive regulation of RNA biosynthetic process#GO:1902680;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;negative regulation of DNA-templated transcription#GO:0045892;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;central nervous system development#GO:0007417;cell differentiation#GO:0030154;negative regulation of metabolic process#GO:0009892;positive regulation of transcription by RNA polymerase II#GO:0045944;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;neuron differentiation#GO:0030182;animal organ development#GO:0048513;multicellular organism development#GO:0007275;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604;nervous system development#GO:0007399;head development#GO:0060322 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;HMG box transcription factor#PC00024;DNA-binding transcription factor#PC00218 HUMAN|HGNC=14716|UniProtKB=Q8NH07 Q8NH07 OR11H2 PTHR24242:SF201 G-PROTEIN COUPLED RECEPTOR OLFACTORY RECEPTOR 11H1-RELATED G-protein coupled receptor#PC00021 HUMAN|HGNC=13019|UniProtKB=Q9NYT6 Q9NYT6 ZNF226 PTHR24376:SF118 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 226 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=4623|UniProtKB=P00390 P00390 GSR PTHR42737:SF2 GLUTATHIONE REDUCTASE GLUTATHIONE REDUCTASE, MITOCHONDRIAL disulfide oxidoreductase activity#GO:0015036;nucleotide binding#GO:0000166;oxidoreductase activity#GO:0016491;heterocyclic compound binding#GO:1901363;catalytic activity#GO:0003824;antioxidant activity#GO:0016209;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;anion binding#GO:0043168;small molecule binding#GO:0036094;flavin adenine dinucleotide binding#GO:0050660;binding#GO:0005488;nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167 cellular response to stress#GO:0033554;cellular response to chemical stimulus#GO:0070887;glutathione metabolic process#GO:0006749;homeostatic process#GO:0042592;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;modified amino acid metabolic process#GO:0006575;cell redox homeostasis#GO:0045454;cellular homeostasis#GO:0019725;response to oxidative stress#GO:0006979;cellular response to chemical stress#GO:0062197;metabolic process#GO:0008152;response to chemical#GO:0042221;cellular response to oxidative stress#GO:0034599;cellular process#GO:0009987;response to stress#GO:0006950;sulfur compound metabolic process#GO:0006790 mitochondrion#GO:0005739;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 reductase#PC00198;oxidoreductase#PC00176 HUMAN|HGNC=19417|UniProtKB=Q494X3 Q494X3 ZNF404 PTHR24381:SF53 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 404 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700 regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=26113|UniProtKB=Q2MV58 Q2MV58 TCTN1 PTHR14611:SF1 TECTONIC FAMILY MEMBER TECTONIC-1 organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;macromolecule localization#GO:0033036;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;plasma membrane bounded cell projection assembly#GO:0120031;cellular component organization or biogenesis#GO:0071840;intracellular protein localization#GO:0008104;cellular component organization#GO:0016043;cilium assembly#GO:0060271;protein localization to organelle#GO:0033365;cell projection organization#GO:0030030;protein localization to cilium#GO:0061512;organelle assembly#GO:0070925;localization#GO:0051179;cilium organization#GO:0044782 organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;membrane-bounded organelle#GO:0043227;ciliary transition zone#GO:0035869;cilium#GO:0005929 HUMAN|HGNC=961|UniProtKB=Q9UIG0 Q9UIG0 BAZ1B PTHR46802:SF1 TYROSINE-PROTEIN KINASE BAZ1B TYROSINE-PROTEIN KINASE BAZ1B histone kinase activity#GO:0035173;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;histone binding#GO:0042393;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein binding#GO:0005515;phosphotransferase activity, alcohol group as acceptor#GO:0016773;histone modifying activity#GO:0140993;protein kinase activity#GO:0004672;binding#GO:0005488 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cellular component organization#GO:0016043;response to stress#GO:0006950;chromatin remodeling#GO:0006338;chromatin organization#GO:0006325;response to stimulus#GO:0050896;DNA damage response#GO:0006974;cellular response to stress#GO:0033554;cellular component organization or biogenesis#GO:0071840 nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;chromatin#GO:0000785;nucleus#GO:0005634;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ATPase complex#GO:1904949;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ISWI-type complex#GO:0031010;SWI/SNF superfamily-type complex#GO:0070603;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 non-receptor tyrosine protein kinase#PC00168;protein modifying enzyme#PC00260 HUMAN|HGNC=3377|UniProtKB=P11171 P11171 EPB41 PTHR23280:SF12 4.1 G PROTEIN PROTEIN 4.1 structural molecule activity#GO:0005198;structural constituent of cytoskeleton#GO:0005200 cytoplasm#GO:0005737;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;cell-cell junction#GO:0005911;membrane#GO:0016020;cell periphery#GO:0071944;membraneless organelle#GO:0043228;cell junction#GO:0030054;cytoskeleton#GO:0005856;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cortical cytoskeleton#GO:0030863;cell cortex#GO:0005938;anchoring junction#GO:0070161;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 actin or actin-binding cytoskeletal protein#PC00041;non-motor actin binding protein#PC00165;cytoskeletal protein#PC00085 Nicotine pharmacodynamics pathway#P06587>EPB41#P06607;Dopamine receptor mediated signaling pathway#P05912>EPB41#P05966 HUMAN|HGNC=37252|UniProtKB=A8MVX0 A8MVX0 ARHGEF33 PTHR46944:SF1 RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 33 RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 33 guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=25700|UniProtKB=Q9HA64 Q9HA64 FN3KRP PTHR12149:SF10 FRUCTOSAMINE 3 KINASE-RELATED PROTEIN KETOSAMINE-3-KINASE kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740 macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;protein modification process#GO:0036211;primary metabolic process#GO:0044238;protein repair#GO:0030091;cellular process#GO:0009987 kinase#PC00137;metabolite interconversion enzyme#PC00262;transferase#PC00220 HUMAN|HGNC=11189|UniProtKB=O00570 O00570 SOX1 PTHR10270:SF328 SOX TRANSCRIPTION FACTOR TRANSCRIPTION FACTOR SOX-1 binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;DNA-binding transcription activator activity#GO:0001216;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837 developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;brain development#GO:0007420;multicellular organismal process#GO:0032501;positive regulation of DNA-templated transcription#GO:0045893;negative regulation of transcription by RNA polymerase II#GO:0000122;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;neuron differentiation#GO:0030182;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;positive regulation of transcription by RNA polymerase II#GO:0045944;multicellular organism development#GO:0007275;animal organ development#GO:0048513;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;head development#GO:0060322;nervous system development#GO:0007399;positive regulation of macromolecule metabolic process#GO:0010604;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;negative regulation of DNA-templated transcription#GO:0045892;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;central nervous system development#GO:0007417;cell differentiation#GO:0030154 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 HMG box transcription factor#PC00024;DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=30831|UniProtKB=Q8NHU6 Q8NHU6 TDRD7 PTHR22948:SF14 TUDOR DOMAIN CONTAINING PROTEIN TUDOR DOMAIN-CONTAINING PROTEIN 7 scaffold/adaptor protein#PC00226 HUMAN|HGNC=9405|UniProtKB=Q16512 Q16512 PKN1 PTHR24356:SF246 SERINE/THREONINE-PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE N1 protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052 non-receptor serine/threonine protein kinase#PC00167 Alzheimer disease-amyloid secretase pathway#P00003>PKC#P00109;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>PKC#P01074 HUMAN|HGNC=10801|UniProtKB=P07988 P07988 SFTPB PTHR11480:SF33 SAPOSIN-RELATED PULMONARY SURFACTANT-ASSOCIATED PROTEIN B metabolic process#GO:0008152;primary metabolic process#GO:0044238;lipid metabolic process#GO:0006629;cellular process#GO:0009987 vesicle#GO:0031982;intracellular vesicle#GO:0097708;secretory vesicle#GO:0099503;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;late endosome#GO:0005770;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HUMAN|HGNC=6186|UniProtKB=P26440 P26440 IVD PTHR43884:SF47 ACYL-COA DEHYDROGENASE ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;catalytic activity#GO:0003824 metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;small molecule catabolic process#GO:0044282;amino acid metabolic process#GO:0006520;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;proteinogenic amino acid metabolic process#GO:0170039;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238 mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 oxidoreductase#PC00176;dehydrogenase#PC00092 HUMAN|HGNC=15948|UniProtKB=Q8N5A5 Q8N5A5 ZGPAT PTHR46297:SF1 ZINC FINGER CCCH-TYPE WITH G PATCH DOMAIN-CONTAINING PROTEIN ZINC FINGER CCCH-TYPE WITH G PATCH DOMAIN-CONTAINING PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription repressor activity#GO:0001217;transcription regulatory region nucleic acid binding#GO:0001067 negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=29479|UniProtKB=Q9BS16 Q9BS16 CENPK PTHR14401:SF6 CENTROMERE PROTEIN K CENTROMERE PROTEIN K HUMAN|HGNC=2993|UniProtKB=Q9NYP3 Q9NYP3 DONSON PTHR12972:SF0 DOWNSTREAM NEIGHBOR OF SON PROTEIN DOWNSTREAM NEIGHBOR OF SON DNA-templated DNA replication#GO:0006261;macromolecule metabolic process#GO:0043170;cell cycle DNA replication#GO:0044786;metabolic process#GO:0008152;nuclear DNA replication#GO:0033260;DNA metabolic process#GO:0006259;nucleobase-containing compound metabolic process#GO:0006139;cell cycle#GO:0007049;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;DNA replication#GO:0006260;cellular process#GO:0009987;cell cycle process#GO:0022402 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=1469|UniProtKB=Q8N5S9 Q8N5S9 CAMKK1 PTHR24346:SF111 MAP/MICROTUBULE AFFINITY-REGULATING KINASE CALCIUM_CALMODULIN-DEPENDENT PROTEIN KINASE KINASE 1 protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein binding#GO:0005515;calcium/calmodulin-dependent protein kinase activity#GO:0004683;binding#GO:0005488;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;calmodulin binding#GO:0005516 biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 CCKR signaling map#P06959>CaMKK#P07034 HUMAN|HGNC=16526|UniProtKB=Q9ULC5 Q9ULC5 ACSL5 PTHR43272:SF112 LONG-CHAIN-FATTY-ACID--COA LIGASE LONG-CHAIN-FATTY-ACID--COA LIGASE 5 ATP-dependent activity#GO:0140657;ligase activity#GO:0016874;catalytic activity#GO:0003824;ligase activity, forming carbon-sulfur bonds#GO:0016877 oxoacid metabolic process#GO:0043436;purine-containing compound biosynthetic process#GO:0072522;regulation of biological process#GO:0050789;purine-containing compound metabolic process#GO:0072521;monocarboxylic acid metabolic process#GO:0032787;phosphorus metabolic process#GO:0006793;carboxylic acid metabolic process#GO:0019752;small molecule metabolic process#GO:0044281;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;regulation of localization#GO:0032879;regulation of transport#GO:0051049;nucleobase-containing small molecule metabolic process#GO:0055086;positive regulation of transport#GO:0051050;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;long-chain fatty acid metabolic process#GO:0001676;sulfur compound metabolic process#GO:0006790;organophosphate biosynthetic process#GO:0090407;regulation of transmembrane transport#GO:0034762;primary metabolic process#GO:0044238;nucleoside phosphate metabolic process#GO:0006753;regulation of cellular process#GO:0050794;lipid metabolic process#GO:0006629;fatty acid metabolic process#GO:0006631;acyl-CoA metabolic process#GO:0006637;nucleoside phosphate biosynthetic process#GO:1901293;positive regulation of cellular process#GO:0048522;organophosphate metabolic process#GO:0019637;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610 membrane#GO:0016020;mitochondrion#GO:0005739;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 ligase#PC00142 HUMAN|HGNC=29947|UniProtKB=Q9UPV9 Q9UPV9 TRAK1 PTHR15751:SF11 TRAFFICKING KINESIN-BINDING PROTEIN TRAFFICKING KINESIN-BINDING PROTEIN 1 cytoskeletal protein binding#GO:0008092;GABA receptor binding#GO:0050811;signaling receptor binding#GO:0005102;binding#GO:0005488;myosin binding#GO:0017022;protein binding#GO:0005515 system development#GO:0048731;anatomical structure development#GO:0048856;localization#GO:0051179;organelle localization#GO:0051640;endosome to lysosome transport#GO:0008333;microtubule-based movement#GO:0007018;neurogenesis#GO:0022008;mitochondrion localization#GO:0051646;vesicle cytoskeletal trafficking#GO:0099518;transport along microtubule#GO:0010970;establishment of localization#GO:0051234;cellular developmental process#GO:0048869;transport#GO:0006810;developmental process#GO:0032502;vacuolar transport#GO:0007034;vesicle transport along microtubule#GO:0047496;intracellular transport#GO:0046907;multicellular organismal process#GO:0032501;cytoskeleton-dependent intracellular transport#GO:0030705;vesicle localization#GO:0051648;cellular localization#GO:0051641;microtubule-based transport#GO:0099111;animal gross anatomical part developmental process#GO:0160108;lysosomal transport#GO:0007041;establishment of organelle localization#GO:0051656;protein targeting#GO:0006605;cell differentiation#GO:0030154;microtubule-based process#GO:0007017;multicellular organism development#GO:0007275;organelle transport along microtubule#GO:0072384;nervous system development#GO:0007399;establishment of vesicle localization#GO:0051650;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649 somatodendritic compartment#GO:0036477;cytoplasm#GO:0005737;neuron projection#GO:0043005;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;mitochondrion#GO:0005739;vesicle#GO:0031982;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;dendrite#GO:0030425;dendritic tree#GO:0097447;intracellular organelle#GO:0043229 membrane traffic protein#PC00150 HUMAN|HGNC=20415|UniProtKB=Q8NBJ7 Q8NBJ7 SUMF2 PTHR23150:SF33 SULFATASE MODIFYING FACTOR 1, 2 INACTIVE C-ALPHA-FORMYLGLYCINE-GENERATING ENZYME 2 oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=37205|UniProtKB=A6NE82 A6NE82 MBD3L3 PTHR12396:SF6 METHYL-CPG BINDING PROTEIN, MBD METHYL-CPG-BINDING DOMAIN PROTEIN 3-LIKE 2-RELATED negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of gene expression, epigenetic#GO:0045814;cellular component organization or biogenesis#GO:0071840;DNA methylation-dependent constitutive heterochromatin formation#GO:0006346;constitutive heterochromatin formation#GO:0140719;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;cellular component assembly#GO:0022607;heterochromatin organization#GO:0070828;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;negative regulation of cellular process#GO:0048523;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;epigenetic regulation of gene expression#GO:0040029;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;chromatin organization#GO:0006325;regulation of RNA biosynthetic process#GO:2001141;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;heterochromatin formation#GO:0031507;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=25677|UniProtKB=Q63HK3 Q63HK3 ZKSCAN2 PTHR23226:SF164 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER PROTEIN WITH KRAB AND SCAN DOMAINS 2 DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=5128|UniProtKB=P09630 P09630 HOXC6 PTHR45659:SF1 HOMEOBOX PROTEIN HOX HOMEOBOX PROTEIN HOX-C6 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987 regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;pattern specification process#GO:0007389;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;regionalization#GO:0003002;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;multicellular organism development#GO:0007275;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;anterior/posterior pattern specification#GO:0009952 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 HUMAN|HGNC=11614|UniProtKB=Q15560 Q15560 TCEA2 PTHR11477:SF3 TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN TRANSCRIPTION ELONGATION FACTOR A PROTEIN 2 transcription elongation factor activity#GO:0003711;transcription regulator activity#GO:0140110 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;DNA-templated transcription elongation#GO:0006354;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;transcription elongation by RNA polymerase II#GO:0006368;gene expression#GO:0010467;transcription by RNA polymerase II#GO:0006366;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031;general transcription factor#PC00259 HUMAN|HGNC=37472|UniProtKB=A0A494C1R9 A0A494C1R9 TSPY9 PTHR11875:SF12 TESTIS-SPECIFIC Y-ENCODED PROTEIN TESTIS-SPECIFIC Y-ENCODED PROTEIN 1-RELATED protein binding#GO:0005515;binding#GO:0005488;histone binding#GO:0042393;chromatin binding#GO:0003682 intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=11861|UniProtKB=Q9BZW4 Q9BZW4 TM6SF2 PTHR14568:SF9 TRANSMEMBRANE SUPERFAMILY 6 MEMBER 1/2 TRANSMEMBRANE 6 SUPERFAMILY MEMBER 2 chemical homeostasis#GO:0048878;regulation of lipid metabolic process#GO:0019216;regulation of biological process#GO:0050789;lipid homeostasis#GO:0055088;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;homeostatic process#GO:0042592;biological regulation#GO:0065007;regulation of cellular process#GO:0050794 endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane#GO:0016020;cytoplasm#GO:0005737;endomembrane system#GO:0012505 HUMAN|HGNC=5201|UniProtKB=O60243 O60243 HS6ST1 PTHR12812:SF1 HEPARAN SULFATE 6-O-SULFOTRANSFERASE 3 HEPARAN-SULFATE 6-O-SULFOTRANSFERASE 1 catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring sulphur-containing groups#GO:0016782;sulfotransferase activity#GO:0008146 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein O-linked glycosylation#GO:0006493;carbohydrate derivative metabolic process#GO:1901135;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;biosynthetic process#GO:0009058;proteoglycan biosynthetic process#GO:0030166;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;proteoglycan metabolic process#GO:0006029;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170 transferase#PC00220 HUMAN|HGNC=31886|UniProtKB=P0C672 P0C672 TSPAN19 PTHR19282:SF211 TETRASPANIN TETRASPANIN-19 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HUMAN|HGNC=5176|UniProtKB=Q13601 Q13601 KRR1 PTHR12581:SF0 HIV-1 REV BINDING PROTEIN 2, 3 KRR1 SMALL SUBUNIT PROCESSOME COMPONENT HOMOLOG membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;preribosome#GO:0030684;ribonucleoprotein complex#GO:1990904;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;small-subunit processome#GO:0032040;organelle lumen#GO:0043233 RNA metabolism protein#PC00031 HUMAN|HGNC=4498|UniProtKB=O14842 O14842 FFAR1 PTHR45822:SF4 FREE FATTY ACID RECEPTOR 2-RELATED FREE FATTY ACID RECEPTOR 1 transmembrane signaling receptor activity#GO:0004888;bioactive lipid receptor activity#GO:0045125;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089 positive regulation of hormone secretion#GO:0046887;cell communication#GO:0007154;regulation of secretion#GO:0051046;response to fatty acid#GO:0070542;regulation of establishment of protein localization#GO:0070201;cellular response to stimulus#GO:0051716;regulation of protein secretion#GO:0050708;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;positive regulation of cellular process#GO:0048522;biological regulation#GO:0065007;positive regulation of cytosolic calcium ion concentration#GO:0007204;G protein-coupled receptor signaling pathway#GO:0007186;response to oxygen-containing compound#GO:1901700;positive regulation of secretion#GO:0051047;regulation of signaling#GO:0023051;regulation of hormone secretion#GO:0046883;positive regulation of signaling#GO:0023056;regulation of protein localization#GO:0032880;regulation of biological quality#GO:0065008;regulation of secretion by cell#GO:1903530;regulation of biological process#GO:0050789;regulation of hormone levels#GO:0010817;response to stimulus#GO:0050896;regulation of protein transport#GO:0051223;signaling#GO:0023052;positive regulation of protein secretion#GO:0050714;regulation of transport#GO:0051049;regulation of localization#GO:0032879;regulation of insulin secretion#GO:0050796;positive regulation of transport#GO:0051050;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;positive regulation of secretion by cell#GO:1903532;cellular process#GO:0009987;response to chemical#GO:0042221;response to lipid#GO:0033993 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HUMAN|HGNC=6306|UniProtKB=O43731 O43731 KDELR3 PTHR10585:SF33 ER LUMEN PROTEIN RETAINING RECEPTOR ER LUMEN PROTEIN-RETAINING RECEPTOR 3 signal sequence receptor activity#GO:0005048 intracellular protein localization#GO:0008104;protein localization to organelle#GO:0033365;cellular localization#GO:0051641;localization#GO:0051179;cellular process#GO:0009987;macromolecule localization#GO:0033036 membrane-bounded organelle#GO:0043227;cis-Golgi network#GO:0005801;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;Golgi apparatus#GO:0005794;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=11800|UniProtKB=Q92748 Q92748 THRSP PTHR14315:SF18 SPOT14 FAMILY MEMBER THYROID HORMONE-INDUCIBLE HEPATIC PROTEIN molecular function inhibitor activity#GO:0140678;molecular function regulator activity#GO:0098772 regulation of biosynthetic process#GO:0009889;regulation of lipid metabolic process#GO:0019216;regulation of lipid biosynthetic process#GO:0046890;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HUMAN|HGNC=5347|UniProtKB=Q14773 Q14773 ICAM4 PTHR13771:SF8 INTERCELLULAR ADHESION MOLECULE INTERCELLULAR ADHESION MOLECULE 4 signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018 cell-cell adhesion#GO:0098609;cell adhesion#GO:0007155;cell adhesion mediated by integrin#GO:0033627;leukocyte cell-cell adhesion#GO:0007159;cellular process#GO:0009987 membrane#GO:0016020;extracellular region#GO:0005576;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cell adhesion molecule#PC00069 HUMAN|HGNC=12307|UniProtKB=Q15645 Q15645 TRIP13 PTHR45991:SF1 PACHYTENE CHECKPOINT PROTEIN 2 PACHYTENE CHECKPOINT PROTEIN 2 HOMOLOG organelle fission#GO:0048285;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;meiosis I cell cycle process#GO:0061982;sexual reproduction#GO:0019953;regulation of cellular process#GO:0050794;reproductive process#GO:0022414;homologous recombination#GO:0035825;negative regulation of cellular component organization#GO:0051129;negative regulation of organelle organization#GO:0010639;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cell cycle#GO:0007049;regulation of cell cycle phase transition#GO:1901987;cellular response to stimulus#GO:0051716;reciprocal homologous recombination#GO:0140527;meiotic nuclear division#GO:0140013;macromolecule metabolic process#GO:0043170;negative regulation of cellular process#GO:0048523;negative regulation of cell cycle process#GO:0010948;regulation of reproductive process#GO:2000241;negative regulation of nuclear division#GO:0051784;regulation of nuclear division#GO:0051783;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;nuclear division#GO:0000280;reciprocal meiotic recombination#GO:0007131;response to stimulus#GO:0050896;regulation of cellular component organization#GO:0051128;regulation of cell cycle#GO:0051726;signaling#GO:0023052;cellular component organization#GO:0016043;meiosis I#GO:0007127;meiotic cell cycle process#GO:1903046;negative regulation of cell cycle phase transition#GO:1901988;negative regulation of biological process#GO:0048519;cell cycle process#GO:0022402;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of meiotic cell cycle#GO:0051445;negative regulation of cell cycle#GO:0045786;cellular component organization or biogenesis#GO:0071840;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;meiotic cell cycle#GO:0051321;DNA recombination#GO:0006310;cell cycle checkpoint signaling#GO:0000075;regulation of cell cycle process#GO:0010564;organelle organization#GO:0006996;cellular process#GO:0009987;signal transduction#GO:0007165 intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;chromosome#GO:0005694;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=26352|UniProtKB=Q8IYW4 Q8IYW4 ENTHD1 PTHR12276:SF57 EPSIN/ENT-RELATED ENTH DOMAIN-CONTAINING PROTEIN 1 clathrin binding#GO:0030276;binding#GO:0005488;phospholipid binding#GO:0005543;lipid binding#GO:0008289;protein binding#GO:0005515 cellular process#GO:0009987;clathrin-dependent endocytosis#GO:0072583;vesicle-mediated transport#GO:0016192;endocytosis#GO:0006897;transport#GO:0006810;receptor-mediated endocytosis#GO:0006898;localization#GO:0051179;establishment of localization#GO:0051234;import into cell#GO:0098657 vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;coated vesicle membrane#GO:0030662;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;clathrin coat#GO:0030118;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;coated vesicle#GO:0030135;coated membrane#GO:0048475;membrane coat#GO:0030117;cell periphery#GO:0071944;vesicle membrane#GO:0012506;membrane#GO:0016020;plasma membrane#GO:0005886;vesicle coat#GO:0030120;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;clathrin vesicle coat#GO:0030125;clathrin-coated vesicle#GO:0030136;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;clathrin-coated vesicle membrane#GO:0030665 membrane traffic protein#PC00150;membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=30773|UniProtKB=Q3ZLR7 Q3ZLR7 SUPT20HL1 PTHR13526:SF17 TRANSCRIPTION FACTOR SPT20 HOMOLOG TRANSCRIPTION FACTOR SPT20 HOMOLOG-LIKE 1 transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 transferase complex#GO:1990234;membraneless organelle#GO:0043228;histone acetyltransferase complex#GO:0000123;intracellular protein-containing complex#GO:0140535;SAGA complex#GO:0000124;chromatin#GO:0000785;protein-containing complex#GO:0032991;peptidase complex#GO:1905368;intracellular membraneless organelle#GO:0043232;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;protein acetyltransferase complex#GO:0031248;SAGA-type complex#GO:0070461;acetyltransferase complex#GO:1902493;intracellular anatomical structure#GO:0005622;chromosome#GO:0005694;organelle#GO:0043226;cellular anatomical structure#GO:0110165 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=20999|UniProtKB=Q9NPJ3 Q9NPJ3 ACOT13 PTHR21660:SF1 THIOESTERASE SUPERFAMILY MEMBER-RELATED ACYL-COENZYME A THIOESTERASE 13 fatty acyl-CoA hydrolase activity#GO:0047617;catalytic activity#GO:0003824;deacylase activity#GO:0160215;acyl-CoA hydrolase activity#GO:0016289;thiolester hydrolase activity#GO:0016790;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787 metabolite interconversion enzyme#PC00262;hydrolase#PC00121;esterase#PC00097 HUMAN|HGNC=23352|UniProtKB=Q8WXW3 Q8WXW3 PIBF1 PTHR18950:SF1 PROGESTERONE-INDUCED BLOCKING FACTOR 1 PROGESTERONE-INDUCED-BLOCKING FACTOR 1 cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cilium assembly#GO:0060271;cellular component organization#GO:0016043;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cell projection organization#GO:0030030;organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031;cilium organization#GO:0044782;cellular component organization or biogenesis#GO:0071840 cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;microtubule cytoskeleton#GO:0015630;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232 HUMAN|HGNC=16947|UniProtKB=O75477 O75477 ERLIN1 PTHR15351:SF2 ERLIN (ER LIPID RAFT ASSOCIATED PROTEIN) HOMOLOG ERLIN-1 binding#GO:0005488;small molecule binding#GO:0036094;sterol binding#GO:0032934;alcohol binding#GO:0043178;cholesterol binding#GO:0015485;lipid binding#GO:0008289;steroid binding#GO:0005496 signal transduction#GO:0007165;cellular process#GO:0009987;response to stress#GO:0006950;biological regulation#GO:0065007;proteasomal protein catabolic process#GO:0010498;SREBP signaling pathway#GO:0032933;response to chemical#GO:0042221;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;signaling#GO:0023052;catabolic process#GO:0009056;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;response to endoplasmic reticulum stress#GO:0034976;ERAD pathway#GO:0036503;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;protein metabolic process#GO:0019538 membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=25301|UniProtKB=Q5HY64 Q5HY64 FAM47C PTHR47415:SF2 PROTEIN FAM47B PROTEIN FAM47C-RELATED HUMAN|HGNC=26973|UniProtKB=Q711Q0 Q711Q0 CEFIP PTHR33775:SF2 CARDIAC-ENRICHED FHL2-INTERACTING PROTEIN-RELATED CARDIAC-ENRICHED FHL2-INTERACTING PROTEIN regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;positive regulation of signaling#GO:0023056;heart process#GO:0003015;regulation of biological process#GO:0050789;muscle system process#GO:0003012;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;regulation of calcineurin-NFAT signaling cascade#GO:0070884;actin filament-based process#GO:0030029;cardiac muscle contraction#GO:0060048;positive regulation of calcium-mediated signaling#GO:0050850;circulatory system process#GO:0003013;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;regulation of calcium-mediated signaling#GO:0050848;striated muscle contraction#GO:0006941;actin-mediated cell contraction#GO:0070252;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of response to stimulus#GO:0048583;muscle contraction#GO:0006936;positive regulation of intracellular signal transduction#GO:1902533;system process#GO:0003008;heart contraction#GO:0060047;cardiac muscle cell contraction#GO:0086003;actin filament-based movement#GO:0030048;positive regulation of cellular process#GO:0048522;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;multicellular organismal process#GO:0032501;positive regulation of response to stimulus#GO:0048584;blood circulation#GO:0008015 myofibril#GO:0030016;membraneless organelle#GO:0043228;sarcomere#GO:0030017;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;intracellular organelle#GO:0043229;I band#GO:0031674;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;organelle#GO:0043226;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;Z disc#GO:0030018;contractile muscle fiber#GO:0043292 HUMAN|HGNC=964|UniProtKB=O75936 O75936 BBOX1 PTHR10696:SF33 GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED GAMMA-BUTYROBETAINE DIOXYGENASE dioxygenase activity#GO:0051213;oxidoreductase activity#GO:0016491;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705 cellular process#GO:0009987;carnitine metabolic process#GO:0009437;modified amino acid metabolic process#GO:0006575;metabolic process#GO:0008152;biosynthetic process#GO:0009058 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;hydroxylase#PC00122 HUMAN|HGNC=3788|UniProtKB=Q04609 Q04609 FOLH1 PTHR10404:SF36 N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE GLUTAMATE CARBOXYPEPTIDASE 2-RELATED catalytic activity#GO:0003824;peptidase activity#GO:0008233;carboxypeptidase activity#GO:0004180;exopeptidase activity#GO:0008238;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 metalloprotease#PC00153 HUMAN|HGNC=18008|UniProtKB=Q6DKJ4 Q6DKJ4 NXN PTHR46472:SF1 NUCLEOREDOXIN NUCLEOREDOXIN protein-disulfide reductase activity#GO:0015035;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491;disulfide oxidoreductase activity#GO:0015036;antioxidant activity#GO:0016209;catalytic activity#GO:0003824;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667 regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;regulation of cell communication#GO:0010646;negative regulation of protein metabolic process#GO:0051248;regulation of Wnt signaling pathway#GO:0030111;negative regulation of biological process#GO:0048519;regulation of protein modification by small protein conjugation or removal#GO:1903320;regulation of biological process#GO:0050789;regulation of post-translational protein modification#GO:1901873;negative regulation of cell communication#GO:0010648;negative regulation of signaling#GO:0023057;negative regulation of protein ubiquitination#GO:0031397;regulation of signaling#GO:0023051;negative regulation of Wnt signaling pathway#GO:0030178;negative regulation of response to stimulus#GO:0048585;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of signal transduction#GO:0009968;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;negative regulation of macromolecule metabolic process#GO:0010605;regulation of protein modification process#GO:0031399;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of protein ubiquitination#GO:0031396 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 oxidoreductase#PC00176 HUMAN|HGNC=26387|UniProtKB=Q8ND83 Q8ND83 SLAIN1 PTHR22406:SF2 NASCENT POLYPEPTIDE-ASSOCIATED COMPLEX SUBUNIT ALPHA, MUSCLE-SPECIFIC FORM SLAIN MOTIF-CONTAINING PROTEIN 1 protein-containing complex organization#GO:0043933;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;regulation of microtubule cytoskeleton organization#GO:0070507;cytoskeleton organization#GO:0007010;positive regulation of cellular component biogenesis#GO:0044089;cellular component assembly#GO:0022607;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;regulation of microtubule polymerization#GO:0031113;positive regulation of organelle organization#GO:0010638;positive regulation of cellular component organization#GO:0051130;regulation of cellular component biogenesis#GO:0044087;cytoplasmic microtubule organization#GO:0031122;regulation of cellular component organization#GO:0051128;regulation of organelle organization#GO:0033043;protein polymerization#GO:0051258;regulation of biological process#GO:0050789;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;regulation of protein-containing complex assembly#GO:0043254;microtubule nucleation#GO:0007020;regulation of microtubule polymerization or depolymerization#GO:0031110;microtubule polymerization#GO:0046785;biological regulation#GO:0065007;positive regulation of protein polymerization#GO:0032273;positive regulation of cellular process#GO:0048522;microtubule polymerization or depolymerization#GO:0031109;supramolecular fiber organization#GO:0097435;microtubule cytoskeleton organization#GO:0000226;regulation of microtubule-based process#GO:0032886;regulation of cellular process#GO:0050794;regulation of protein polymerization#GO:0032271;regulation of cytoskeleton organization#GO:0051493;regulation of supramolecular fiber organization#GO:1902903 polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;microtubule#GO:0005874;microtubule plus-end#GO:0035371;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;supramolecular complex#GO:0099080;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;microtubule end#GO:1990752 HUMAN|HGNC=29370|UniProtKB=Q8IWB1 Q8IWB1 ITPRIP PTHR10656:SF8 CELL FATE DETERMINING PROTEIN MAB21-RELATED INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR-INTERACTING PROTEIN transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;transferase activity, transferring phosphorus-containing groups#GO:0016772;enzyme inhibitor activity#GO:0004857;kinase inhibitor activity#GO:0019210;protein kinase regulator activity#GO:0019887;protein kinase inhibitor activity#GO:0004860;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678 cellular anatomical structure#GO:0110165;membrane#GO:0016020 transferase#PC00220;nucleotidyltransferase#PC00174 HUMAN|HGNC=9382|UniProtKB=P22612 P22612 PRKACG PTHR24353:SF137 CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT GAMMA protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;renal absorption#GO:0070293;system process#GO:0003008;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;cellular process#GO:0009987;renal system process#GO:0003014;signal transduction#GO:0007165 catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;transferase complex#GO:1990234;protein kinase complex#GO:1902911;intracellular protein-containing complex#GO:0140535;nucleus#GO:0005634;cytosol#GO:0005829;cytoplasm#GO:0005737;protein-containing complex#GO:0032991 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>PKA#P01075;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>PKA-c#P00707;Histamine H2 receptor mediated signaling pathway#P04386>PKA#P04491;CCKR signaling map#P06959>PKA-Calpha/beta/gamma#P07099;5HT1 type receptor mediated signaling pathway#P04373>PKA#P04403;Metabotropic glutamate receptor group II pathway#P00040>PKA#P01050;Enkephalin release#P05913>PKA#P05972;Metabotropic glutamate receptor group I pathway#P00041>PKA#P01059;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PKA#P00862;GABA-B receptor II signaling#P05731>PKA#P05752;Beta2 adrenergic receptor signaling pathway#P04378>PKA#P04444;Endothelin signaling pathway#P00019>PKA#P00570;Dopamine receptor mediated signaling pathway#P05912>PKA#P05946;Beta1 adrenergic receptor signaling pathway#P04377>PKA#P04437;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>PKA#P00746;Metabotropic glutamate receptor group III pathway#P00039>PKA#P01035 HUMAN|HGNC=14150|UniProtKB=Q8N461 Q8N461 FBXL16 PTHR13318:SF193 PARTNER OF PAIRED, ISOFORM B-RELATED F-BOX_LRR-REPEAT PROTEIN 16 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941 cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535;SCF ubiquitin ligase complex#GO:0019005;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;transferase complex#GO:1990234;catalytic complex#GO:1902494 HUMAN|HGNC=31834|UniProtKB=Q96N77 Q96N77 ZNF641 PTHR24381:SF409 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 641 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=6415|UniProtKB=P13646 P13646 KRT13 PTHR23239:SF121 INTERMEDIATE FILAMENT KERATIN, TYPE I CYTOSKELETAL 13 structural molecule activity#GO:0005198 intermediate filament-based process#GO:0045103;animal gross anatomical part developmental process#GO:0160108;intermediate filament organization#GO:0045109;tissue morphogenesis#GO:0048729;anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;intermediate filament cytoskeleton organization#GO:0045104;cell differentiation#GO:0030154;developmental process#GO:0032502;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;morphogenesis of an epithelium#GO:0002009;organelle organization#GO:0006996;cellular process#GO:0009987;epithelium development#GO:0060429;epithelial cell differentiation#GO:0030855;tissue development#GO:0009888;cytoskeleton organization#GO:0007010 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;intermediate filament#GO:0005882;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;supramolecular complex#GO:0099080;organelle#GO:0043226;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232 intermediate filament#PC00129 HUMAN|HGNC=27540|UniProtKB=Q86VI1 Q86VI1 EXOC3L1 PTHR21292:SF12 EXOCYST COMPLEX COMPONENT SEC6-RELATED EXOCYST COMPLEX COMPONENT 3-LIKE PROTEIN binding#GO:0005488;SNARE binding#GO:0000149;protein binding#GO:0005515 transport#GO:0006810;localization#GO:0051179;secretion#GO:0046903;establishment of localization#GO:0051234;exocytosis#GO:0006887;secretion by cell#GO:0032940;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;export from cell#GO:0140352 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;exocyst#GO:0000145;cell periphery#GO:0071944;cell cortex#GO:0005938;intracellular anatomical structure#GO:0005622;vesicle tethering complex#GO:0099023 membrane traffic protein#PC00150 HUMAN|HGNC=11851|UniProtKB=O60602 O60602 TLR5 PTHR24365:SF525 TOLL-LIKE RECEPTOR TOLL-LIKE RECEPTOR 5 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 activation of innate immune response#GO:0002218;positive regulation of innate immune response#GO:0045089;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of response to stress#GO:0080134;regulation of response to stimulus#GO:0048583;positive regulation of defense response#GO:0031349;positive regulation of immune response#GO:0050778;regulation of innate immune response#GO:0045088;pattern recognition receptor signaling pathway#GO:0002221;positive regulation of response to biotic stimulus#GO:0002833;innate immune response-activating signaling pathway#GO:0002758;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of response to biotic stimulus#GO:0002831;regulation of defense response#GO:0031347;regulation of immune response#GO:0050776;cell communication#GO:0007154;positive regulation of immune system process#GO:0002684;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;signal transduction#GO:0007165;regulation of response to external stimulus#GO:0032101;positive regulation of response to external stimulus#GO:0032103;immune response-activating signaling pathway#GO:0002757;toll-like receptor signaling pathway#GO:0002224;immune response-regulating signaling pathway#GO:0002764;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signaling#GO:0023052;immune system process#GO:0002376 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=14888|UniProtKB=O75190 O75190 DNAJB6 PTHR43948:SF6 DNAJ HOMOLOG SUBFAMILY B DNAJ HOMOLOG SUBFAMILY B MEMBER 6 binding#GO:0005488;protein-folding chaperone binding#GO:0051087;protein binding#GO:0005515 protein folding#GO:0006457;biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 chaperone#PC00072 HUMAN|HGNC=15919|UniProtKB=O14734 O14734 ACOT8 PTHR11066:SF34 ACYL-COA THIOESTERASE ACYL-COENZYME A THIOESTERASE 8 hydrolase activity#GO:0016787;fatty acyl-CoA hydrolase activity#GO:0047617;acyl-CoA hydrolase activity#GO:0016289;deacylase activity#GO:0160215;catalytic activity#GO:0003824;thiolester hydrolase activity#GO:0016790;hydrolase activity, acting on ester bonds#GO:0016788 fatty acid catabolic process#GO:0009062;oxoacid metabolic process#GO:0043436;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;small molecule catabolic process#GO:0044282;nucleoside phosphate metabolic process#GO:0006753;monocarboxylic acid metabolic process#GO:0032787;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;purine-containing compound metabolic process#GO:0072521;nucleobase-containing small molecule metabolic process#GO:0055086;acyl-CoA metabolic process#GO:0006637;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;lipid metabolic process#GO:0006629;monocarboxylic acid catabolic process#GO:0072329;nucleobase-containing compound metabolic process#GO:0006139;organophosphate metabolic process#GO:0019637;sulfur compound metabolic process#GO:0006790;lipid catabolic process#GO:0016042;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;peroxisome#GO:0005777;microbody#GO:0042579;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;peroxisomal matrix#GO:0005782;membrane-bounded organelle#GO:0043227 metabolite interconversion enzyme#PC00262;esterase#PC00097;hydrolase#PC00121 HUMAN|HGNC=26946|UniProtKB=Q96HJ9 Q96HJ9 FMC1 PTHR31716:SF1 PROTEIN FMC1 HOMOLOG PROTEIN FMC1 HOMOLOG cellular component assembly#GO:0022607;mitochondrion organization#GO:0007005;mitochondrial respiratory chain complex assembly#GO:0033108;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;mitochondrial proton-transporting ATP synthase complex assembly#GO:0033615 mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=42967|UniProtKB=A6NEH6 A6NEH6 TMEM247 PTHR36691:SF1 TRANSMEMBRANE PROTEIN 247 TRANSMEMBRANE PROTEIN 247 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=26674|UniProtKB=A8TX70 A8TX70 COL6A5 PTHR22588:SF4 VWFA DOMAIN-CONTAINING PROTEIN COLLAGEN ALPHA-5(VI) CHAIN cellular component organization#GO:0016043;extracellular structure organization#GO:0043062;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;external encapsulating structure organization#GO:0045229 cellular anatomical structure#GO:0110165;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576 HUMAN|HGNC=11042|UniProtKB=P30531 P30531 SLC6A1 PTHR11616:SF138 SODIUM/CHLORIDE DEPENDENT TRANSPORTER SODIUM- AND CHLORIDE-DEPENDENT GABA TRANSPORTER 1 carboxylic acid transmembrane transporter activity#GO:0046943;solute:sodium symporter activity#GO:0015370;amino acid:sodium symporter activity#GO:0005283;chloride transmembrane transporter activity#GO:0015108;transmembrane transporter activity#GO:0022857;solute:monoatomic cation symporter activity#GO:0015294;sodium ion transmembrane transporter activity#GO:0015081;active transmembrane transporter activity#GO:0022804;symporter activity#GO:0015293;monoatomic cation transmembrane transporter activity#GO:0008324;amino acid transmembrane transporter activity#GO:0015171;secondary active transmembrane transporter activity#GO:0015291;monoatomic anion transmembrane transporter activity#GO:0008509;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873 monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;localization#GO:0051179;transport#GO:0006810;amino acid transport#GO:0006865;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;sodium ion transport#GO:0006814;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725 axon#GO:0030424;neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cell surface#GO:0009986;cellular anatomical structure#GO:0110165 primary active transporter#PC00068 HUMAN|HGNC=649|UniProtKB=P48444 P48444 ARCN1 PTHR10121:SF0 COATOMER SUBUNIT DELTA COATOMER SUBUNIT DELTA structural molecule activity#GO:0005198;protein complex scaffold activity#GO:0140378 endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;Golgi vesicle transport#GO:0048193;transport#GO:0006810;intracellular transport#GO:0046907;organelle localization#GO:0051640;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;COPI vesicle coat#GO:0030126;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;coated vesicle membrane#GO:0030662;Golgi-associated vesicle membrane#GO:0030660;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;vesicle#GO:0031982;membrane coat#GO:0030117;coated membrane#GO:0048475;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;coated vesicle#GO:0030135;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;COPI-coated vesicle#GO:0030137;cytoplasm#GO:0005737;vesicle coat#GO:0030120;membrane#GO:0016020;vesicle membrane#GO:0012506;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;Golgi apparatus#GO:0005794;Golgi-associated vesicle#GO:0005798 vesicle coat protein#PC00235;membrane traffic protein#PC00150 HUMAN|HGNC=26409|UniProtKB=Q96NL1 Q96NL1 TMEM74 PTHR16125:SF3 TRANSMEMBRANE PROTEIN 74 TRANSMEMBRANE PROTEIN 74 HUMAN|HGNC=23639|UniProtKB=Q6PGP7 Q6PGP7 SKIC3 PTHR15704:SF7 SUPERKILLER 3 PROTEIN-RELATED SUPERKILLER COMPLEX PROTEIN 3 RNA catabolic process#GO:0006401;RNA metabolic process#GO:0016070;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;negative regulation of cellular process#GO:0048523;macromolecule metabolic process#GO:0043170;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleobase-containing compound catabolic process#GO:0034655;mRNA catabolic process#GO:0006402;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;nucleic acid catabolic process#GO:0141188;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 HUMAN|HGNC=29874|UniProtKB=Q6I9Y2 Q6I9Y2 THOC7 PTHR23405:SF5 MAINTENANCE OF KILLER 16 MAK16 PROTEIN-RELATED THO COMPLEX SUBUNIT 7 nuclear export#GO:0051168;nuclear transport#GO:0051169;mRNA export from nucleus#GO:0006406;nucleic acid transport#GO:0050657;cellular localization#GO:0051641;localization#GO:0051179;nucleocytoplasmic transport#GO:0006913;mRNA transport#GO:0051028;establishment of RNA localization#GO:0051236;RNA transport#GO:0050658;RNA localization#GO:0006403;nucleobase-containing compound transport#GO:0015931;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;transport#GO:0006810;RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907;metabolic process#GO:0008152;biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;establishment of localization in cell#GO:0051649;nitrogen compound transport#GO:0071705;macromolecule localization#GO:0033036 intracellular organelle#GO:0043229;transcription export complex#GO:0000346;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;THO complex#GO:0000347;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226 HUMAN|HGNC=13743|UniProtKB=Q9BYJ1 Q9BYJ1 ALOXE3 PTHR11771:SF184 LIPOXYGENASE HYDROPEROXIDE ISOMERASE ALOXE3 oxidoreductase activity#GO:0016491;dioxygenase activity#GO:0051213;oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen#GO:0016702;catalytic activity#GO:0003824 lipid biosynthetic process#GO:0008610;icosanoid metabolic process#GO:0006690;biosynthetic process#GO:0009058;fatty acid biosynthetic process#GO:0006633;long-chain fatty acid metabolic process#GO:0001676;cellular process#GO:0009987;lipid modification#GO:0030258;monocarboxylic acid biosynthetic process#GO:0072330;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;unsaturated fatty acid metabolic process#GO:0033559;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;small molecule metabolic process#GO:0044281;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;arachidonate metabolic process#GO:0019369;carboxylic acid biosynthetic process#GO:0046394;lipid oxidation#GO:0034440;oxoacid metabolic process#GO:0043436;olefinic compound metabolic process#GO:0120254 oxidoreductase#PC00176;oxygenase#PC00177 HUMAN|HGNC=29090|UniProtKB=A6NHR9 A6NHR9 SMCHD1 PTHR22640:SF3 STRUCTURAL MAINTENANCE OF CHROMOSOMES FLEXIBLE HINGE DOMAIN-CONTAINING PROTEIN 1 STRUCTURAL MAINTENANCE OF CHROMOSOMES FLEXIBLE HINGE DOMAIN-CONTAINING PROTEIN 1 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;chromosome#GO:0005694;organelle lumen#GO:0043233;nucleus#GO:0005634 HUMAN|HGNC=6029|UniProtKB=P15248 P15248 IL9 PTHR16926:SF1 INTERLEUKIN 9 INTERLEUKIN-9 signaling receptor regulator activity#GO:0030545;growth factor receptor binding#GO:0070851;receptor ligand activity#GO:0048018;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;signaling receptor binding#GO:0005102;cytokine receptor binding#GO:0005126;binding#GO:0005488;cytokine activity#GO:0005125;molecular function activator activity#GO:0140677;protein binding#GO:0005515 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207;cytokine#PC00083;interleukin superfamily#PC00128 Interleukin signaling pathway#P00036>Interleukin#P00970 HUMAN|HGNC=25676|UniProtKB=Q5T7V8 Q5T7V8 GORAB PTHR21470:SF29 RAB6-INTERACTING PROTEIN GORAB RAB6-INTERACTING GOLGIN cellular process#GO:0009987;cell projection assembly#GO:0030031;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cell projection organization#GO:0030030;organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031;cilium organization#GO:0044782;non-motile cilium assembly#GO:1905515;cellular component organization or biogenesis#GO:0071840 HUMAN|HGNC=11140|UniProtKB=Q16143 Q16143 SNCB PTHR13820:SF4 SYNUCLEIN BETA-SYNUCLEIN metal ion binding#GO:0046872;cation binding#GO:0043169;small molecule binding#GO:0036094;binding#GO:0005488;copper ion binding#GO:0005507;ion binding#GO:0043167;transition metal ion binding#GO:0046914 transport#GO:0006810;synaptic vesicle cycle#GO:0099504;import into cell#GO:0098657;vesicle-mediated transport in synapse#GO:0099003;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;synaptic signaling#GO:0099536;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;synaptic vesicle recycling#GO:0036465;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;trans-synaptic signaling#GO:0099537;synapse organization#GO:0050808;cellular localization#GO:0051641;cell communication#GO:0007154;localization#GO:0051179;cellular component organization#GO:0016043;chemical synaptic transmission#GO:0007268;synaptic vesicle endocytosis#GO:0048488;regulation of biological process#GO:0050789;cell junction organization#GO:0034330;endocytosis#GO:0006897;anterograde trans-synaptic signaling#GO:0098916;signaling#GO:0023052 axon#GO:0030424;intracellular anatomical structure#GO:0005622;cell body#GO:0044297;distal axon#GO:0150034;plasma membrane bounded cell projection#GO:0120025;neuronal cell body#GO:0043025;neuron projection terminus#GO:0044306;cell projection#GO:0042995;synapse#GO:0045202;cellular anatomical structure#GO:0110165;axon terminus#GO:0043679;cell junction#GO:0030054;presynapse#GO:0098793;neuron projection#GO:0043005;cytoplasm#GO:0005737;somatodendritic compartment#GO:0036477 membrane trafficking regulatory protein#PC00151;membrane traffic protein#PC00150 Parkinson disease#P00049>beta-Synuclein#P01217 HUMAN|HGNC=34348|UniProtKB=Q6NT89 Q6NT89 TRNP1 PTHR40714:SF1 TMF-REGULATED NUCLEAR PROTEIN 1 TMF-REGULATED NUCLEAR PROTEIN 1 binding#GO:0005488;nucleic acid binding#GO:0003676;DNA binding#GO:0003677 anatomical structure morphogenesis#GO:0009653;nervous system development#GO:0007399;head development#GO:0060322;multicellular organismal process#GO:0032501;brain development#GO:0007420;central nervous system development#GO:0007417;developmental process#GO:0032502;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;anatomical structure development#GO:0048856;animal organ development#GO:0048513;multicellular organism development#GO:0007275 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=25559|UniProtKB=Q9HCM1 Q9HCM1 RESF1 PTHR21604:SF0 RETROELEMENT SILENCING FACTOR 1 RETROELEMENT SILENCING FACTOR 1 protein binding#GO:0005515;enzyme binding#GO:0019899;binding#GO:0005488 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=6919|UniProtKB=O95243 O95243 MBD4 PTHR15074:SF7 METHYL-CPG-BINDING PROTEIN METHYL-CPG-BINDING DOMAIN PROTEIN 4 nucleic acid binding#GO:0003676;binding#GO:0005488;DNA binding#GO:0003677 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=951|UniProtKB=P78367 P78367 NKX3-2 PTHR24340:SF34 HOMEOBOX PROTEIN NKX HOMEOBOX PROTEIN NKX-3.2 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987 regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;developmental process#GO:0032502 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=17299|UniProtKB=Q6XPS3 Q6XPS3 TPTE2 PTHR12305:SF99 PHOSPHATASE WITH HOMOLOGY TO TENSIN PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE TPTE2-RELATED hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 protein phosphatase#PC00195;protein modifying enzyme#PC00260 Hypoxia response via HIF activation#P00030>PTEN#P00824;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>PTEN#G04675;p53 pathway#P00059>PTEN#P01480;p53 pathway feedback loops 2#P04398>PTEN#P04658;p53 pathway#P00059>PTEN#G01579;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>PTEN#P00905;p53 pathway feedback loops 2#P04398>PTEN#G04714 HUMAN|HGNC=44668|UniProtKB=H3BQB6 H3BQB6 STMND1 PTHR10104:SF20 STATHMIN STATHMIN DOMAIN-CONTAINING PROTEIN 1 protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;binding#GO:0005488 generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;neuron development#GO:0048666;cellular component disassembly#GO:0022411;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;cellular component organization#GO:0016043;cell development#GO:0048468;regulation of cellular component organization#GO:0051128;cell projection organization#GO:0030030;cell differentiation#GO:0030154;neuron differentiation#GO:0030182;protein-containing complex organization#GO:0043933;microtubule-based process#GO:0007017;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;neuron projection development#GO:0031175;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;nervous system development#GO:0007399;regulation of microtubule cytoskeleton organization#GO:0070507;microtubule depolymerization#GO:0007019;regulation of microtubule-based process#GO:0032886;supramolecular fiber organization#GO:0097435;system development#GO:0048731;microtubule cytoskeleton organization#GO:0000226;anatomical structure development#GO:0048856;protein-containing complex disassembly#GO:0032984;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794;developmental process#GO:0032502;regulation of microtubule polymerization or depolymerization#GO:0031110;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;microtubule polymerization or depolymerization#GO:0031109;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;protein depolymerization#GO:0051261;multicellular organismal process#GO:0032501 cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;intracellular anatomical structure#GO:0005622;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;neuron projection#GO:0043005 non-motor microtubule binding protein#PC00166;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=4425|UniProtKB=Q08379 Q08379 GOLGA2 PTHR10881:SF58 GOLGIN SUBFAMILY A MEMBER-RELATED GOLGIN SUBFAMILY A MEMBER 2 cellular process#GO:0009987;mitotic spindle assembly#GO:0090307;cellular component biogenesis#GO:0044085;mitotic sister chromatid segregation#GO:0000070;organelle organization#GO:0006996;spindle assembly#GO:0051225;endomembrane system organization#GO:0010256;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;chromosome segregation#GO:0007059;mitotic cell cycle process#GO:1903047;microtubule-based process#GO:0007017;chromosome organization#GO:0051276;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;Golgi organization#GO:0007030;mitotic nuclear division#GO:0140014;cell cycle process#GO:0022402;cell cycle#GO:0007049;nuclear chromosome segregation#GO:0098813;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;sister chromatid segregation#GO:0000819;microtubule cytoskeleton organization involved in mitosis#GO:1902850;mitotic cell cycle#GO:0000278;mitotic spindle organization#GO:0007052;organelle assembly#GO:0070925;nuclear division#GO:0000280;microtubule cytoskeleton organization#GO:0000226;organelle fission#GO:0048285 cytoplasm#GO:0005737;Golgi cis cisterna#GO:0000137;endomembrane system#GO:0012505;Golgi cisterna#GO:0031985;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;organelle membrane#GO:0031090;cis-Golgi network#GO:0005801;Golgi apparatus#GO:0005794;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;Golgi stack#GO:0005795;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular organelle#GO:0043229 membrane traffic protein#PC00150 HUMAN|HGNC=10486|UniProtKB=P23297 P23297 S100A1 PTHR11639:SF160 S100 CALCIUM-BINDING PROTEIN PROTEIN S100-A1 protein binding#GO:0005515;metal ion binding#GO:0046872;cation binding#GO:0043169;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;calcium ion binding#GO:0005509 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;sarcoplasmic reticulum#GO:0016529;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;sarcoplasm#GO:0016528;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 calmodulin-related#PC00061;calcium-binding protein#PC00060 HUMAN|HGNC=30310|UniProtKB=Q9BSG5 Q9BSG5 RTBDN PTHR10517:SF19 FOLATE RECEPTOR RETBINDIN molecular transducer activity#GO:0060089;binding#GO:0005488;small molecule binding#GO:0036094;anion binding#GO:0043168;ion binding#GO:0043167;heterocyclic compound binding#GO:1901363;signaling receptor activity#GO:0038023;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 transport#GO:0006810;nitrogen compound transport#GO:0071705;localization#GO:0051179;establishment of localization#GO:0051234;vitamin transport#GO:0051180 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=30743|UniProtKB=Q969D9 Q969D9 TSLP PTHR38003:SF1 THYMIC STROMAL LYMPHOPOIETIN THYMIC STROMAL LYMPHOPOIETIN cytokine receptor binding#GO:0005126;binding#GO:0005488;signaling receptor binding#GO:0005102;cytokine activity#GO:0005125;protein binding#GO:0005515;molecular function activator activity#GO:0140677;signaling receptor regulator activity#GO:0030545;growth factor receptor binding#GO:0070851;receptor ligand activity#GO:0048018;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546 regulation of biological process#GO:0050789;positive regulation of multicellular organismal process#GO:0051240;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of signaling#GO:0023056;positive regulation of cytokine-mediated signaling pathway#GO:0001961;regulation of signaling#GO:0023051;positive regulation of macromolecule metabolic process#GO:0010604;regulation of response to external stimulus#GO:0032101;regulation of multicellular organismal process#GO:0051239;regulation of response to cytokine stimulus#GO:0060759;positive regulation of biological process#GO:0048518;positive regulation of response to external stimulus#GO:0032103;regulation of cytokine-mediated signaling pathway#GO:0001959;positive regulation of inflammatory response#GO:0050729;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of cytokine production#GO:0001819;positive regulation of cell communication#GO:0010647;regulation of cell communication#GO:0010646;positive regulation of signal transduction#GO:0009967;positive regulation of biosynthetic process#GO:0009891;regulation of inflammatory response#GO:0050727;regulation of defense response#GO:0031347;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cytokine production#GO:0001817;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of cellular process#GO:0048522;regulation of biosynthetic process#GO:0009889;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;regulation of response to stress#GO:0080134;positive regulation of defense response#GO:0031349;regulation of response to stimulus#GO:0048583 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=18856|UniProtKB=Q96BA8 Q96BA8 CREB3L1 PTHR46004:SF1 CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN A CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 1 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690 regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>CREB#P00713;Transcription regulation by bZIP transcription factor#P00055>CREB#P01383 HUMAN|HGNC=13030|UniProtKB=Q99592 Q99592 ZBTB18 PTHR24394:SF18 ZINC FINGER PROTEIN ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 18 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=21558|UniProtKB=Q5TD94 Q5TD94 RSPH4A PTHR13159:SF4 RADIAL SPOKEHEAD-RELATED RADIAL SPOKE HEAD PROTEIN 4 HOMOLOG A cellular component organization#GO:0016043;cilium assembly#GO:0060271;microtubule-based movement#GO:0007018;cell projection organization#GO:0030030;microtubule bundle formation#GO:0001578;cilium movement#GO:0003341;organelle assembly#GO:0070925;cilium organization#GO:0044782;axoneme assembly#GO:0035082;microtubule cytoskeleton organization#GO:0000226;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;plasma membrane bounded cell projection assembly#GO:0120031;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840 cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;ciliary plasm#GO:0097014;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;axoneme#GO:0005930;intracellular organelle#GO:0043229;cilium#GO:0005929;cytoskeleton#GO:0005856 microtubule or microtubule-binding cytoskeletal protein#PC00157;cytoskeletal protein#PC00085 HUMAN|HGNC=1600|UniProtKB=O60583 O60583 CCNT2 PTHR10026:SF43 CYCLIN CYCLIN-T2 molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;protein kinase regulator activity#GO:0019887;cyclin-dependent protein kinase regulator activity#GO:0019914;cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538;protein serine/threonine kinase activator activity#GO:0043539;enzyme activator activity#GO:0008047;protein kinase activator activity#GO:0030295;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;kinase activator activity#GO:0019209 regulation of biological process#GO:0050789;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;positive regulation of DNA-templated transcription, elongation#GO:0032786;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of DNA-templated transcription elongation#GO:0032784;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of DNA-templated transcription#GO:0006355;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 transferase complex#GO:1990234;protein kinase complex#GO:1902911;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;transcription elongation factor complex#GO:0008023;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654 kinase activator#PC00138;kinase modulator#PC00140 HUMAN|HGNC=30691|UniProtKB=Q8NFY9 Q8NFY9 KBTBD8 PTHR24412:SF433 KELCH PROTEIN KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 8 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;enzyme-substrate adaptor activity#GO:0140767;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;cullin-RING ubiquitin ligase complex#GO:0031461;ubiquitin ligase complex#GO:0000151;Cul3-RING ubiquitin ligase complex#GO:0031463;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;transferase complex#GO:1990234;catalytic complex#GO:1902494 scaffold/adaptor protein#PC00226 HUMAN|HGNC=2711|UniProtKB=Q14203 Q14203 DCTN1 PTHR18916:SF95 DYNACTIN 1-RELATED MICROTUBULE-BINDING DYNACTIN SUBUNIT 1 spindle localization#GO:0051653;microtubule cytoskeleton organization#GO:0000226;cellular localization#GO:0051641;localization#GO:0051179;organelle localization#GO:0051640;establishment or maintenance of cell polarity#GO:0007163;establishment of organelle localization#GO:0051656;mitotic cell cycle#GO:0000278;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cellular component organization#GO:0016043;cell cycle#GO:0007049;cell cycle process#GO:0022402;establishment of cell polarity#GO:0030010;nuclear migration#GO:0007097;establishment of localization#GO:0051234;establishment of mitotic spindle orientation#GO:0000132;cellular component organization or biogenesis#GO:0071840;establishment of spindle orientation#GO:0051294;microtubule-based process#GO:0007017;mitotic cell cycle process#GO:1903047;intracellular transport#GO:0046907;transport#GO:0006810;cytoskeleton organization#GO:0007010;establishment of mitotic spindle localization#GO:0040001;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of spindle localization#GO:0051293;establishment of localization in cell#GO:0051649 neuron projection#GO:0043005;microtubule cytoskeleton#GO:0015630;condensed chromosome, centromeric region#GO:0000779;intracellular membraneless organelle#GO:0043232;supramolecular complex#GO:0099080;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;spindle#GO:0005819;cytoskeleton#GO:0005856;condensed chromosome#GO:0000793;chromosome, centromeric region#GO:0000775;membraneless organelle#GO:0043228;kinetochore#GO:0000776;spindle pole#GO:0000922;chromosome#GO:0005694;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;axon#GO:0030424;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687 chaperone#PC00072 Huntington disease#P00029>Dynactin#P00781 HUMAN|HGNC=18212|UniProtKB=Q9UM19 Q9UM19 HPCAL4 PTHR23055:SF84 CALCIUM BINDING PROTEINS HIPPOCALCIN-LIKE PROTEIN 4 small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;calcium ion binding#GO:0005509;metal ion binding#GO:0046872;cation binding#GO:0043169 calmodulin-related#PC00061 HUMAN|HGNC=32222|UniProtKB=P0C5J1 P0C5J1 FAM86B2 PTHR14614:SF117 HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN PROTEIN-LYSINE N-METHYLTRANSFERASE EEF2KMT-RELATED lysine N-methyltransferase activity#GO:0016278;N-methyltransferase activity#GO:0008170;protein-lysine N-methyltransferase activity#GO:0016279;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;catalytic activity, acting on a protein#GO:0140096;protein methyltransferase activity#GO:0008276;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity#GO:0003824;transferase activity#GO:0016740 protein modifying enzyme#PC00260 HUMAN|HGNC=26128|UniProtKB=Q9H741 Q9H741 SPRING1 PTHR13481:SF0 SREBP REGULATING GENE PROTEIN SREBP REGULATING GENE PROTEIN HUMAN|HGNC=29363|UniProtKB=Q9C0D6 Q9C0D6 FHDC1 PTHR45691:SF1 PROTEIN DIAPHANOUS FH2 DOMAIN-CONTAINING PROTEIN 1 actin filament polymerization#GO:0030041;actin cytoskeleton organization#GO:0030036;protein-containing complex assembly#GO:0065003;protein polymerization#GO:0051258;cellular component organization#GO:0016043;supramolecular fiber organization#GO:0097435;actin filament-based process#GO:0030029;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;actin polymerization or depolymerization#GO:0008154;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;actin filament organization#GO:0007015;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840 intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;actin filament#GO:0005884;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;organelle#GO:0043226;supramolecular complex#GO:0099080;actin cytoskeleton#GO:0015629 cytoskeletal protein#PC00085 HUMAN|HGNC=9872|UniProtKB=Q15283 Q15283 RASA2 PTHR10194:SF21 RAS GTPASE-ACTIVATING PROTEINS RAS GTPASE-ACTIVATING PROTEIN 2 GTPase-activating protein#PC00257 FGF signaling pathway#P00021>RasGAP#P00646;PDGF signaling pathway#P00047>RasGAP#P01152;EGF receptor signaling pathway#P00018>GAP#P00546 HUMAN|HGNC=10001|UniProtKB=O15539 O15539 RGS5 PTHR10845:SF42 REGULATOR OF G PROTEIN SIGNALING REGULATOR OF G PROTEIN SIGNALING 5 enzyme activator activity#GO:0008047;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 negative regulation of cell communication#GO:0010648;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;regulation of G protein-coupled receptor signaling pathway#GO:0008277;negative regulation of cellular process#GO:0048523;negative regulation of signaling#GO:0023057;regulation of cell communication#GO:0010646;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of response to stimulus#GO:0048585;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of G protein-coupled receptor signaling pathway#GO:0045744;negative regulation of biological process#GO:0048519 membrane#GO:0016020;cytoplasmic side of plasma membrane#GO:0009898;cytoplasmic side of membrane#GO:0098562;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;plasma membrane#GO:0005886 GTPase-activating protein#PC00257 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>RGS#P00731;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>RGS#P00704 HUMAN|HGNC=23469|UniProtKB=Q5T2L2 Q5T2L2 AKR1C8 PTHR11732:SF529 ALDO/KETO REDUCTASE ALDO-KETO REDUCTASE FAMILY 1 MEMBER C8 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen#GO:0016709;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;monooxygenase activity#GO:0004497;oxidoreductase activity#GO:0016491;alcohol dehydrogenase (NADP+) activity#GO:0008106;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614 steroid metabolic process#GO:0008202;cellular process#GO:0009987;lipid metabolic process#GO:0006629;primary metabolic process#GO:0044238;metabolic process#GO:0008152 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 reductase#PC00198;oxidoreductase#PC00176 HUMAN|HGNC=5799|UniProtKB=P01615 P01615 IGKV2D-28 PTHR23267:SF499 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN KAPPA VARIABLE 2-28-RELATED response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 protein-containing complex#GO:0032991 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=6799|UniProtKB=P43365 P43365 MAGEA12 PTHR11736:SF142 MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN MELANOMA-ASSOCIATED ANTIGEN 12 protein binding#GO:0005515;histone deacetylase binding#GO:0042826;binding#GO:0005488;enzyme binding#GO:0019899 negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 scaffold/adaptor protein#PC00226 HUMAN|HGNC=1081|UniProtKB=Q01954 Q01954 BNC1 PTHR15021:SF1 DISCONNECTED-RELATED ZINC FINGER PROTEIN BASONUCLIN-1 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of transcription by RNA polymerase I#GO:0006356;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 gene-specific transcriptional regulator#PC00264;zinc finger transcription factor#PC00244 HUMAN|HGNC=8204|UniProtKB=P47890 P47890 OR1G1 PTHR48001:SF186 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 1G1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=28611|UniProtKB=Q6R327 Q6R327 RICTOR PTHR13298:SF11 CYTOSOLIC REGULATOR PIANISSIMO RAPAMYCIN-INSENSITIVE COMPANION OF MTOR structural molecule activity#GO:0005198;protein complex scaffold activity#GO:0140378 regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;intracellular signal transduction#GO:0035556;regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051896;positive regulation of signaling#GO:0023056;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;TORC2 signaling#GO:0038203;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;signaling#GO:0023052;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051897;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;TOR signaling#GO:0031929;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of response to stimulus#GO:0048584 TOR complex#GO:0038201;intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991 HUMAN|HGNC=17125|UniProtKB=Q8NFB2 Q8NFB2 TMEM185A PTHR13568:SF2 FAM11A, B PROTEIN TRANSMEMBRANE PROTEIN 185A neuron projection#GO:0043005;dendritic tree#GO:0097447;dendrite#GO:0030425;plasma membrane bounded cell projection#GO:0120025;somatodendritic compartment#GO:0036477;cell projection#GO:0042995;cellular anatomical structure#GO:0110165 HUMAN|HGNC=11131|UniProtKB=O00161 O00161 SNAP23 PTHR19305:SF4 SYNAPTOSOMAL ASSOCIATED PROTEIN SYNAPTOSOMAL-ASSOCIATED PROTEIN 23 protein binding#GO:0005515;syntaxin binding#GO:0019905;SNAP receptor activity#GO:0005484;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;SNARE binding#GO:0000149;molecular adaptor activity#GO:0060090 anterograde trans-synaptic signaling#GO:0098916;vesicle fusion#GO:0006906;chemical synaptic transmission#GO:0007268;signal release from synapse#GO:0099643;secretion#GO:0046903;localization#GO:0051179;cell communication#GO:0007154;trans-synaptic signaling#GO:0099537;signal release#GO:0023061;synaptic vesicle fusion to presynaptic active zone membrane#GO:0031629;neurotransmitter secretion#GO:0007269;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;membrane organization#GO:0061024;synaptic vesicle membrane organization#GO:0048499;membrane fusion#GO:0061025;establishment of localization#GO:0051234;transport#GO:0006810;synaptic vesicle cycle#GO:0099504;export from cell#GO:0140352;signaling#GO:0023052;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;protein-containing complex assembly#GO:0065003;cellular localization#GO:0051641;secretion by cell#GO:0032940;vesicle-mediated transport#GO:0016192;organelle fusion#GO:0048284;cellular component assembly#GO:0022607;organelle membrane fusion#GO:0090174;neurotransmitter transport#GO:0006836;endomembrane system organization#GO:0010256;synaptic signaling#GO:0099536;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;synaptic vesicle exocytosis#GO:0016079;vesicle-mediated transport in synapse#GO:0099003;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;vesicle organization#GO:0016050;exocytosis#GO:0006887;vesicle fusion to plasma membrane#GO:0099500;regulated exocytosis#GO:0045055;exocytic process#GO:0140029 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;plasma membrane#GO:0005886;SNARE complex#GO:0031201;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;membrane protein complex#GO:0098796 membrane traffic protein#PC00150;SNARE protein#PC00034 Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>SNARE Complex#P01066;Opioid proopiomelanocortin pathway#P05917>SNARE Complex#P06005;Metabotropic glutamate receptor group II pathway#P00040>SNARE Complex#P01049;Ionotropic glutamate receptor pathway#P00037>SNARE Complex#P01013;Nicotinic acetylcholine receptor signaling pathway#P00044>SNARE Complex#P01091;Cortocotropin releasing factor receptor signaling pathway#P04380>SNARE Complex#P04457;Metabotropic glutamate receptor group III pathway#P00039>SNARE Complex#P01042;Thyrotropin-releasing hormone receptor signaling pathway#P04394>SNARE Complex#P04582;Oxytocin receptor mediated signaling pathway#P04391>SNARE Complex#P04532;Opioid proenkephalin pathway#P05915>SNARE Complex#P05986;5HT2 type receptor mediated signaling pathway#P04374>SNARE Complex#P04415;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>SNARE Complex#P01079;5HT4 type receptor mediated signaling pathway#P04376>SNARE Complex#P04428;Alpha adrenergic receptor signaling pathway#P00002>SNARE#P00074;5HT1 type receptor mediated signaling pathway#P04373>SNARE Complex#P04405;Beta1 adrenergic receptor signaling pathway#P04377>SNARE Complex#P04435;Adrenaline and noradrenaline biosynthesis#P00001>SNARE#P00072;Beta3 adrenergic receptor signaling pathway#P04379>SNARE Complex#P04447;Dopamine receptor mediated signaling pathway#P05912>SNARE Complex#P05956;Beta2 adrenergic receptor signaling pathway#P04378>SNARE Complex#P04442;Opioid prodynorphin pathway#P05916>SNARE Complex#P05996;5HT3 type receptor mediated signaling pathway#P04375>SNARE Complex#P04423 HUMAN|HGNC=19869|UniProtKB=Q96GP6 Q96GP6 SCARF2 PTHR24043:SF5 SCAVENGER RECEPTOR CLASS F SCAVENGER RECEPTOR CLASS F MEMBER 2 cargo receptor activity#GO:0038024 cellular process#GO:0009987;heterophilic cell-cell adhesion#GO:0007157;cell adhesion#GO:0007155;cell-cell adhesion#GO:0098609 membrane traffic protein#PC00150 HUMAN|HGNC=20917|UniProtKB=Q96QP1 Q96QP1 ALPK1 PTHR46747:SF1 ALPHA-PROTEIN KINASE 1 ALPHA-PROTEIN KINASE 1 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=5107|UniProtKB=P31267 P31267 HOXA6 PTHR45659:SF14 HOMEOBOX PROTEIN HOX HOMEOBOX PROTEIN HOX-A6 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 pattern specification process#GO:0007389;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;developmental process#GO:0032502;anterior/posterior pattern specification#GO:0009952;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;multicellular organism development#GO:0007275;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regionalization#GO:0003002;regulation of nucleobase-containing compound metabolic process#GO:0019219 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 HUMAN|HGNC=24092|UniProtKB=Q9H213 Q9H213 MAGEH1 PTHR11736:SF8 MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN MELANOMA-ASSOCIATED ANTIGEN H1 regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 scaffold/adaptor protein#PC00226 HUMAN|HGNC=9558|UniProtKB=Q9UNM6 Q9UNM6 PSMD13 PTHR10539:SF0 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13 primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;peptidase complex#GO:1905368;cytoplasm#GO:0005737;cytosol#GO:0005829;proteasome complex#GO:0000502;nucleus#GO:0005634;intracellular protein-containing complex#GO:0140535;proteasome regulatory particle, lid subcomplex#GO:0008541;endopeptidase complex#GO:1905369 protein modifying enzyme#PC00260;protease#PC00190 Cell cycle#P00013>Proteasome#P00480;Ubiquitin proteasome pathway#P00060>26S proteasome#P01489;Parkinson disease#P00049>19S proteasome#P01209 HUMAN|HGNC=29999|UniProtKB=Q86X02 Q86X02 CDR2L PTHR19232:SF10 CENTROCORTIN FAMILY MEMBER CEREBELLAR DEGENERATION-RELATED PROTEIN 2-LIKE HUMAN|HGNC=2074|UniProtKB=Q13286 Q13286 CLN3 PTHR10981:SF0 BATTENIN BATTENIN cellular homeostasis#GO:0019725;receptor-mediated endocytosis#GO:0006898;intracellular chemical homeostasis#GO:0055082;vesicle cytoskeletal trafficking#GO:0099518;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;transport#GO:0006810;vacuolar transport#GO:0007034;intracellular transport#GO:0046907;vesicle transport along microtubule#GO:0047496;biological regulation#GO:0065007;cytoskeleton-dependent intracellular transport#GO:0030705;vesicle localization#GO:0051648;Golgi to vacuole transport#GO:0006896;localization#GO:0051179;regulation of intracellular pH#GO:0051453;regulation of pH#GO:0006885;organelle localization#GO:0051640;homeostatic process#GO:0042592;microtubule-based movement#GO:0007018;microtubule-based process#GO:0007017;import into cell#GO:0098657;Golgi vesicle transport#GO:0048193;amino acid transport#GO:0006865;chemical homeostasis#GO:0048878;organelle transport along microtubule#GO:0072384;establishment of vesicle localization#GO:0051650;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;monoatomic ion homeostasis#GO:0050801;regulation of biological quality#GO:0065008;post-Golgi vesicle-mediated transport#GO:0006892;cellular localization#GO:0051641;microtubule-based transport#GO:0099111;lysosomal transport#GO:0007041;cytosolic transport#GO:0016482;endocytosis#GO:0006897;establishment of organelle localization#GO:0051656;intracellular monoatomic ion homeostasis#GO:0006873 vesicle#GO:0031982;lysosome#GO:0005764;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;vacuole#GO:0005773;cytoplasm#GO:0005737;late endosome#GO:0005770;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;lytic vacuole#GO:0000323 membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=14120|UniProtKB=P20231 P20231 TPSB2 PTHR24256:SF532 TRYPTASE-RELATED TRYPTASE ALPHA_BETA-1-RELATED serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;serine-type peptidase activity#GO:0008236;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;catalytic activity#GO:0003824 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;primary metabolic process#GO:0044238;proteolysis#GO:0006508;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 serine protease#PC00203 HUMAN|HGNC=61|UniProtKB=P33897 P33897 ABCD1 PTHR11384:SF21 ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 1 transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804;monocarboxylic acid transmembrane transporter activity#GO:0008028;nucleotide binding#GO:0000166;carboxylic acid transmembrane transporter activity#GO:0046943;small molecule binding#GO:0036094;anion binding#GO:0043168;ion binding#GO:0043167;ribonucleotide binding#GO:0032553;transporter activity#GO:0005215;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657;ATP binding#GO:0005524;binding#GO:0005488;nucleoside phosphate binding#GO:1901265 catabolic process#GO:0009056;carboxylic acid transmembrane transport#GO:1905039;primary metabolic process#GO:0044238;lipid oxidation#GO:0034440;localization#GO:0051179;fatty acid transport#GO:0015908;monocarboxylic acid transport#GO:0015718;peroxisomal transport#GO:0043574;monocarboxylic acid catabolic process#GO:0072329;lipid transport#GO:0006869;macromolecule localization#GO:0033036;carboxylic acid catabolic process#GO:0046395;establishment of localization#GO:0051234;lipid modification#GO:0030258;fatty acid metabolic process#GO:0006631;intracellular transport#GO:0046907;lipid metabolic process#GO:0006629;fatty acid beta-oxidation#GO:0006635;transport#GO:0006810;small molecule metabolic process#GO:0044281;small molecule catabolic process#GO:0044282;very long-chain fatty acid metabolic process#GO:0000038;carboxylic acid metabolic process#GO:0019752;cellular component organization#GO:0016043;monocarboxylic acid metabolic process#GO:0032787;transmembrane transport#GO:0055085;cellular localization#GO:0051641;fatty acid catabolic process#GO:0009062;oxoacid metabolic process#GO:0043436;lipid localization#GO:0010876;peroxisome organization#GO:0007031;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;lipid catabolic process#GO:0016042;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;carboxylic acid transport#GO:0046942;organic acid transport#GO:0015849;fatty acid oxidation#GO:0019395 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;peroxisome#GO:0005777;membrane#GO:0016020;microbody#GO:0042579;organelle#GO:0043226;peroxisomal membrane#GO:0005778;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 primary active transporter#PC00068;ATP-binding cassette (ABC) transporter#PC00003 HUMAN|HGNC=12542|UniProtKB=P0DTE4 P0DTE4 UGT2A1 PTHR48043:SF140 EG:EG0003.4 PROTEIN-RELATED UDP-GLUCURONOSYLTRANSFERASE 2A1 catalytic activity#GO:0003824;glucuronosyltransferase activity#GO:0015020;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758;glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194 HUMAN|HGNC=3590|UniProtKB=Q12884 Q12884 FAP PTHR11731:SF136 PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED PROLYL ENDOPEPTIDASE FAP hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;proteolysis#GO:0006508;metabolic process#GO:0008152;primary metabolic process#GO:0044238;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 serine protease#PC00203;protease#PC00190 HUMAN|HGNC=3279|UniProtKB=Q99613 Q99613 EIF3C PTHR13937:SF0 EUKARYOTIC TRANSLATION INITIATION FACTOR 3, SUBUNIT 8 EIF3S8 -RELATED EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT C-RELATED translation initiation factor activity#GO:0003743;translation factor activity#GO:0180051 biosynthetic process#GO:0009058;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;translation#GO:0006412;translational initiation#GO:0006413;metabolic process#GO:0008152 eukaryotic translation initiation factor 3 complex#GO:0005852;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 translational protein#PC00263;translation initiation factor#PC00224;translation factor#PC00223 HUMAN|HGNC=1499|UniProtKB=P29466 P29466 CASP1 PTHR47901:SF3 CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18 CASPASE-1 cysteine-type endopeptidase activity#GO:0004197;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234 positive regulation of programmed cell death#GO:0043068;regulation of cellular process#GO:0050794;regulation of programmed cell death#GO:0043067;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;protein metabolic process#GO:0019538;proteolysis#GO:0006508;regulation of defense response#GO:0031347;regulation of inflammatory response#GO:0050727;protein maturation#GO:0051604;gene expression#GO:0010467;regulation of response to external stimulus#GO:0032101;biological regulation#GO:0065007;biosynthetic process#GO:0009058;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein processing#GO:0016485;positive regulation of apoptotic process#GO:0043065;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;regulation of response to stress#GO:0080134;regulation of response to stimulus#GO:0048583;regulation of apoptotic process#GO:0042981 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;canonical inflammasome complex#GO:0061702 HUMAN|HGNC=1634|UniProtKB=P06126 P06126 CD1A PTHR16675:SF160 MHC CLASS I-RELATED T-CELL SURFACE GLYCOPROTEIN CD1A antigen binding#GO:0003823;binding#GO:0005488;lipid binding#GO:0008289 regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;response to stimulus#GO:0050896;positive regulation of adaptive immune response#GO:0002821;regulation of biological process#GO:0050789;regulation of leukocyte mediated immunity#GO:0002703;regulation of leukocyte mediated cytotoxicity#GO:0001910;regulation of immune effector process#GO:0002697;antigen processing and presentation#GO:0019882;positive regulation of lymphocyte mediated immunity#GO:0002708;regulation of cell killing#GO:0031341;regulation of immune response#GO:0050776;regulation of lymphocyte mediated immunity#GO:0002706;immune system process#GO:0002376;positive regulation of immune effector process#GO:0002699;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;positive regulation of biological process#GO:0048518;immune response#GO:0006955;positive regulation of cellular process#GO:0048522;positive regulation of immune system process#GO:0002684;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;positive regulation of leukocyte mediated immunity#GO:0002705 side of membrane#GO:0098552;extracellular region#GO:0005576;external side of plasma membrane#GO:0009897;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 major histocompatibility complex protein#PC00149;defense/immunity protein#PC00090 HUMAN|HGNC=30706|UniProtKB=Q96JA4 Q96JA4 MS4A14 PTHR23320:SF10 MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 14 transporter#PC00227 HUMAN|HGNC=25198|UniProtKB=Q96AG3 Q96AG3 SLC25A46 PTHR21252:SF2 TB1 PROTEIN-RELATED MITOCHONDRIAL OUTER MEMBRANE PROTEIN SLC25A46 neuron differentiation#GO:0030182;developmental process#GO:0032502;neurogenesis#GO:0022008;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;cellular process#GO:0009987;neuron projection development#GO:0031175;organelle organization#GO:0006996;axon development#GO:0061564;mitochondrion organization#GO:0007005;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;mitochondrial fission#GO:0000266;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;neuron development#GO:0048666;anatomical structure development#GO:0048856;organelle fission#GO:0048285;cellular component organization#GO:0016043;cell development#GO:0048468;cell differentiation#GO:0030154;cell projection organization#GO:0030030 outer membrane#GO:0019867;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle envelope#GO:0031967;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;mitochondrial outer membrane#GO:0005741;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane#GO:0016020;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;organelle outer membrane#GO:0031968;cytoplasm#GO:0005737 HUMAN|HGNC=21667|UniProtKB=Q96SN7 Q96SN7 ORAI2 PTHR31501:SF5 CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL PROTEIN 1 PROTEIN ORAI-2 passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;calcium channel activity#GO:0005262;monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085 localization#GO:0051179;monoatomic cation transport#GO:0006812;establishment of localization#GO:0051234;metal ion transport#GO:0030001;monoatomic ion transport#GO:0006811;calcium ion transport#GO:0006816;transport#GO:0006810 cellular anatomical structure#GO:0110165;membrane#GO:0016020 ion channel#PC00133 HUMAN|HGNC=26315|UniProtKB=Q76KP1 Q76KP1 B4GALNT4 PTHR12369:SF46 CHONDROITIN SYNTHASE N-ACETYL-BETA-GLUCOSAMINYL-GLYCOPROTEIN 4-BETA-N-ACETYLGALACTOSAMINYLTRANSFERASE 1 UDP-glycosyltransferase activity#GO:0008194;acetylgalactosaminyltransferase activity#GO:0008376;glycosyltransferase activity#GO:0016757;transferase activity#GO:0016740;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycosyltransferase#PC00111 HUMAN|HGNC=9314|UniProtKB=Q08209 Q08209 PPP3CA PTHR45673:SF5 SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED PROTEIN PHOSPHATASE 3 CATALYTIC SUBUNIT ALPHA catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;catalytic activity#GO:0003824;calmodulin binding#GO:0005516;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;protein binding#GO:0005515;hydrolase activity#GO:0016787;protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721;binding#GO:0005488 calcineurin-NFAT signaling cascade#GO:0033173;calcineurin-mediated signaling#GO:0097720;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;intracellular signaling cassette#GO:0141124;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;calcium-mediated signaling#GO:0019722 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;protein serine/threonine phosphatase complex#GO:0008287;catalytic complex#GO:1902494;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195 B cell activation#P00010>Calcineurin#P00386;Wnt signaling pathway#P00057>Calcineurin#P01446;T cell activation#P00053>Calcineurin#P01315;Gonadotropin-releasing hormone receptor pathway#P06664>Caln#P06728;CCKR signaling map#P06959>CaN#P07178 HUMAN|HGNC=25849|UniProtKB=Q7L2K0 Q7L2K0 TEDC2 PTHR14870:SF1 TUBULIN EPSILON AND DELTA COMPLEX PROTEIN 2 TUBULIN EPSILON AND DELTA COMPLEX PROTEIN 2 HUMAN|HGNC=39125|UniProtKB=Q8IYP2 Q8IYP2 PRSS58 PTHR24271:SF56 KALLIKREIN-RELATED SERINE PROTEASE 58 serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233 primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;extracellular region#GO:0005576;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;secretory vesicle#GO:0099503 serine protease#PC00203 HUMAN|HGNC=24943|UniProtKB=Q8TBP5 Q8TBP5 FAM174A PTHR28607:SF1 EXPRESSED PROTEIN MEMBRANE PROTEIN FAM174A HUMAN|HGNC=9280|UniProtKB=P50336 P50336 PPOX PTHR42923:SF3 PROTOPORPHYRINOGEN OXIDASE PROTOPORPHYRINOGEN OXIDASE catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 oxidoreductase#PC00176;oxidase#PC00175 Heme biosynthesis#P02746>Protoporphyrinogen oxidase#P02976 HUMAN|HGNC=10996|UniProtKB=O14975 O14975 SLC27A2 PTHR43107:SF4 LONG-CHAIN FATTY ACID TRANSPORT PROTEIN LONG-CHAIN FATTY ACID TRANSPORT PROTEIN 2 ligase activity, forming carbon-sulfur bonds#GO:0016877;ATP-dependent activity#GO:0140657;carboxylic acid transmembrane transporter activity#GO:0046943;catalytic activity#GO:0003824;ligase activity#GO:0016874;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monocarboxylic acid transmembrane transporter activity#GO:0008028 steroid metabolic process#GO:0008202;lipid transport#GO:0006869;cellular process#GO:0009987;long-chain fatty acid metabolic process#GO:0001676;macromolecule localization#GO:0033036;import into cell#GO:0098657;establishment of localization#GO:0051234;lipid metabolic process#GO:0006629;carboxylic acid transport#GO:0046942;transport#GO:0006810;organic acid transport#GO:0015849;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;small molecule metabolic process#GO:0044281;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;monocarboxylic acid metabolic process#GO:0032787;monocarboxylic acid transport#GO:0015718;fatty acid transport#GO:0015908;localization#GO:0051179;lipid localization#GO:0010876;oxoacid metabolic process#GO:0043436 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;cell periphery#GO:0071944;membrane#GO:0016020;cytoplasm#GO:0005737;plasma membrane#GO:0005886;endomembrane system#GO:0012505;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090 secondary carrier transporter#PC00258 HUMAN|HGNC=21192|UniProtKB=Q9H0C1 Q9H0C1 ZMYND12 PTHR46533:SF1 ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 12 ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 12 HUMAN|HGNC=26905|UniProtKB=Q8NBZ0 Q8NBZ0 INO80E PTHR21812:SF1 INO80 COMPLEX SUBUNIT E INO80 COMPLEX SUBUNIT E positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;chromatin organization#GO:0006325;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;regulation of gene expression#GO:0010468;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of DNA metabolic process#GO:0051052;cellular component organization#GO:0016043;chromatin remodeling#GO:0006338;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of DNA replication#GO:0006275;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355 Ino80 complex#GO:0031011;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;chromatin#GO:0000785;membrane-enclosed lumen#GO:0031974;INO80-type complex#GO:0097346;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ATPase complex#GO:1904949;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;SWI/SNF superfamily-type complex#GO:0070603;organelle lumen#GO:0043233;chromosome#GO:0005694 HUMAN|HGNC=8039|UniProtKB=P30989 P30989 NTSR1 PTHR24243:SF9 G-PROTEIN COUPLED RECEPTOR NEUROTENSIN RECEPTOR TYPE 1 neuropeptide receptor activity#GO:0008188;G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;neuropeptide signaling pathway#GO:0007218;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021 HUMAN|HGNC=13594|UniProtKB=Q96FV3 Q96FV3 TSPAN17 PTHR19282:SF470 TETRASPANIN TETRASPANIN-17 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HUMAN|HGNC=17949|UniProtKB=Q5JTD0 Q5JTD0 TJAP1 PTHR28664:SF3 TIGHT JUNCTION-ASSOCIATED PROTEIN 1 TIGHT JUNCTION-ASSOCIATED PROTEIN 1 Golgi organization#GO:0007030;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;endomembrane system organization#GO:0010256;cellular component organization or biogenesis#GO:0071840 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;Golgi apparatus subcompartment#GO:0098791;trans-Golgi network#GO:0005802;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226 tight junction#PC00214;cell junction protein#PC00070 HUMAN|HGNC=5758|UniProtKB=A0A0B4J1Z2 A0A0B4J1Z2 IGKV1D-43 PTHR23267:SF539 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN KAPPA VARIABLE 1-9-RELATED immune response#GO:0006955;immune system process#GO:0002376;response to stimulus#GO:0050896 protein-containing complex#GO:0032991 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=15562|UniProtKB=Q9UHA7 Q9UHA7 IL36A PTHR10078:SF25 INTERLEUKIN-1 FAMILY MEMBER INTERLEUKIN-36 ALPHA molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;cytokine activity#GO:0005125 cellular process#GO:0009987;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;cellular response to lipopolysaccharide#GO:0071222;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;response to lipid#GO:0033993;cellular response to lipid#GO:0071396;response to cytokine#GO:0034097;response to chemical#GO:0042221;cell surface receptor signaling pathway#GO:0007166;response to lipopolysaccharide#GO:0032496;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;response to molecule of bacterial origin#GO:0002237;biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052;response to stimulus#GO:0050896;response to oxygen-containing compound#GO:1901700;immune system process#GO:0002376;cellular response to chemical stimulus#GO:0070887;response to peptide#GO:1901652;immune response#GO:0006955;response to other organism#GO:0051707;biological regulation#GO:0065007;defense response#GO:0006952;response to external stimulus#GO:0009605;cellular response to molecule of bacterial origin#GO:0071219;cellular response to stimulus#GO:0051716;cellular response to biotic stimulus#GO:0071216;response to external biotic stimulus#GO:0043207;regulation of cellular process#GO:0050794;inflammatory response#GO:0006954;response to bacterium#GO:0009617;cytokine-mediated signaling pathway#GO:0019221;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207;interleukin superfamily#PC00128;cytokine#PC00083 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>IL2#P00870 HUMAN|HGNC=8888|UniProtKB=P18669 P18669 PGAM1 PTHR11931:SF15 PHOSPHOGLYCERATE MUTASE PHOSPHOGLYCERATE MUTASE 1 intramolecular phosphotransferase activity#GO:0016868;catalytic activity#GO:0003824;intramolecular transferase activity#GO:0016866;isomerase activity#GO:0016853;phosphoglycerate mutase activity#GO:0004619 monocarboxylic acid metabolic process#GO:0032787;phosphorus metabolic process#GO:0006793;carboxylic acid metabolic process#GO:0019752;purine nucleotide metabolic process#GO:0006163;pyridine-containing compound catabolic process#GO:0072526;ribonucleoside diphosphate metabolic process#GO:0009185;purine-containing compound metabolic process#GO:0072521;small molecule metabolic process#GO:0044281;pyruvate metabolic process#GO:0006090;pyridine nucleotide catabolic process#GO:0019364;small molecule catabolic process#GO:0044282;oxoacid metabolic process#GO:0043436;purine nucleoside diphosphate metabolic process#GO:0009135;ribonucleotide metabolic process#GO:0009259;nucleotide metabolic process#GO:0009117;carbohydrate catabolic process#GO:0016052;nicotinamide nucleotide metabolic process#GO:0046496;cellular process#GO:0009987;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;metabolic process#GO:0008152;monosaccharide metabolic process#GO:0005996;purine ribonucleotide metabolic process#GO:0009150;ADP catabolic process#GO:0046032;purine-containing compound catabolic process#GO:0072523;glucose metabolic process#GO:0006006;nucleobase-containing small molecule metabolic process#GO:0055086;purine nucleoside diphosphate catabolic process#GO:0009137;hexose metabolic process#GO:0019318;primary metabolic process#GO:0044238;purine ribonucleotide catabolic process#GO:0009154;nucleoside diphosphate catabolic process#GO:0009134;purine nucleoside triphosphate metabolic process#GO:0009144;catabolic process#GO:0009056;nucleoside phosphate catabolic process#GO:1901292;carbohydrate metabolic process#GO:0005975;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate derivative catabolic process#GO:1901136;nucleoside phosphate metabolic process#GO:0006753;nucleoside diphosphate metabolic process#GO:0009132;pyridine-containing compound metabolic process#GO:0072524;purine nucleotide catabolic process#GO:0006195;organophosphate catabolic process#GO:0046434;ribonucleoside diphosphate catabolic process#GO:0009191;cellular respiration#GO:0045333;aerobic respiration#GO:0009060;purine ribonucleoside diphosphate catabolic process#GO:0009181;nucleobase-containing compound catabolic process#GO:0034655;organophosphate metabolic process#GO:0019637;ribonucleotide catabolic process#GO:0009261;carbohydrate derivative metabolic process#GO:1901135;purine ribonucleoside triphosphate metabolic process#GO:0009205;glycolytic process#GO:0006096;nucleobase-containing compound metabolic process#GO:0006139;nucleotide catabolic process#GO:0009166;generation of precursor metabolites and energy#GO:0006091;purine ribonucleoside diphosphate metabolic process#GO:0009179;ADP metabolic process#GO:0046031;energy derivation by oxidation of organic compounds#GO:0015980 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 mutase#PC00160;isomerase#PC00135 Glycolysis#P00024>Phosphoglyceromutase#P00680 HUMAN|HGNC=17362|UniProtKB=Q14865 Q14865 ARID5B PTHR13964:SF37 RBP-RELATED AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 5B sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 transcription cofactor#PC00217 HUMAN|HGNC=637|UniProtKB=P55087 P55087 AQP4 PTHR19139:SF34 AQUAPORIN TRANSPORTER AQUAPORIN-4 passive transmembrane transporter activity#GO:0022803;water transmembrane transporter activity#GO:0005372;water channel activity#GO:0015250;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;channel activity#GO:0015267 transport#GO:0006810;fluid transport#GO:0042044;establishment of localization#GO:0051234;water transport#GO:0006833;localization#GO:0051179 basal plasma membrane#GO:0009925;cell periphery#GO:0071944;basolateral plasma membrane#GO:0016323;basal part of cell#GO:0045178;membrane#GO:0016020;plasma membrane#GO:0005886;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165 transporter#PC00227 HUMAN|HGNC=9286|UniProtKB=Q13522 Q13522 PPP1R1A PTHR15417:SF4 PROTEIN PHOSPHATASE INHIBITOR AND DOPAMINE- AND CAMP-REGULATED NEURONAL PHOSPHOPROTEIN PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 1A enzyme regulator activity#GO:0030234;protein phosphatase regulator activity#GO:0019888;molecular function inhibitor activity#GO:0140678;phosphatase regulator activity#GO:0019208;phosphatase inhibitor activity#GO:0019212;molecular function regulator activity#GO:0098772;protein phosphatase inhibitor activity#GO:0004864;enzyme inhibitor activity#GO:0004857 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 phosphatase inhibitor#PC00183;protein-binding activity modulator#PC00095;phosphatase modulator#PC00184 HUMAN|HGNC=429|UniProtKB=P18054 P18054 ALOX12 PTHR11771:SF4 LIPOXYGENASE POLYUNSATURATED FATTY ACID LIPOXYGENASE ALOX12 dioxygenase activity#GO:0051213;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen#GO:0016702;catalytic activity#GO:0003824 lipid metabolic process#GO:0006629;unsaturated fatty acid metabolic process#GO:0033559;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;lipid modification#GO:0030258;cellular process#GO:0009987;long-chain fatty acid metabolic process#GO:0001676;icosanoid metabolic process#GO:0006690;olefinic compound metabolic process#GO:0120254;oxoacid metabolic process#GO:0043436;lipid oxidation#GO:0034440;arachidonate metabolic process#GO:0019369;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;monocarboxylic acid metabolic process#GO:0032787;small molecule metabolic process#GO:0044281 intracellular anatomical structure#GO:0005622;sarcolemma#GO:0042383;plasma membrane#GO:0005886;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;cytosol#GO:0005829;membrane#GO:0016020 oxygenase#PC00177;oxidoreductase#PC00176 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Lipoxygenase#P00830 HUMAN|HGNC=26641|UniProtKB=A1L4H1 A1L4H1 SSC5D PTHR19331:SF487 SCAVENGER RECEPTOR DOMAIN-CONTAINING SOLUBLE SCAVENGER RECEPTOR CYSTEINE-RICH DOMAIN-CONTAINING PROTEIN SSC5D cargo receptor activity#GO:0038024 serine protease#PC00203;protease#PC00190 HUMAN|HGNC=22949|UniProtKB=Q5TB30 Q5TB30 DEPDC1 PTHR16206:SF12 DEP DOMAIN-CONTAINING DEP DOMAIN-CONTAINING PROTEIN 1A negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of metabolic process#GO:0009892;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;transcription repressor complex#GO:0017053;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HUMAN|HGNC=22950|UniProtKB=Q70Z35 Q70Z35 PREX2 PTHR22829:SF1 DEP DOMAIN PROTEIN PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE-DEPENDENT RAC EXCHANGER 2 PROTEIN enzyme activator activity#GO:0008047;enzyme inhibitor activity#GO:0004857;kinase inhibitor activity#GO:0019210;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;protein kinase regulator activity#GO:0019887;protein kinase inhibitor activity#GO:0004860;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;molecular function activator activity#GO:0140677 regulation of cellular process#GO:0050794;negative regulation of TOR signaling#GO:0032007;response to stimulus#GO:0050896;regulation of cell communication#GO:0010646;signaling#GO:0023052;negative regulation of biological process#GO:0048519;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;negative regulation of intracellular signal transduction#GO:1902532;cell communication#GO:0007154;negative regulation of cell communication#GO:0010648;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;G protein-coupled receptor signaling pathway#GO:0007186;regulation of signaling#GO:0023051;negative regulation of response to stimulus#GO:0048585;negative regulation of signal transduction#GO:0009968;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;cellular process#GO:0009987;regulation of TOR signaling#GO:0032006;signal transduction#GO:0007165;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 protein-binding activity modulator#PC00095;G-protein modulator#PC00022;guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=1618|UniProtKB=P48643 P48643 CCT5 PTHR11353:SF186 CHAPERONIN T-COMPLEX PROTEIN 1 SUBUNIT EPSILON protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;protein folding#GO:0006457;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152 protein folding chaperone complex#GO:0101031;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;chaperonin-containing T-complex#GO:0005832;cytosol#GO:0005829;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 chaperonin#PC00073 HUMAN|HGNC=7781|UniProtKB=Q14494 Q14494 NFE2L1 PTHR24411:SF31 NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR ENDOPLASMIC RETICULUM MEMBRANE SENSOR NFE2L1 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 basic leucine zipper transcription factor#PC00056 HUMAN|HGNC=14625|UniProtKB=Q9BXL8 Q9BXL8 CDCA4 PTHR16277:SF6 CELL DIVISION CYCLE ASSOCIATED PROTEIN 4/SERTA DOMAIN-CONTAINING PROTEIN 2 CELL DIVISION CYCLE-ASSOCIATED PROTEIN 4 transcription coactivator activity#GO:0003713;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 transcription cofactor#PC00217 HUMAN|HGNC=32480|UniProtKB=Q96EL1 Q96EL1 INKA1 PTHR28615:SF1 PAK4-INHIBITOR INKA1-RELATED PAK4-INHIBITOR INKA1 molecular function inhibitor activity#GO:0140678;protein binding#GO:0005515;enzyme regulator activity#GO:0030234;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;binding#GO:0005488;kinase binding#GO:0019900;kinase regulator activity#GO:0019207;protein kinase inhibitor activity#GO:0004860;molecular function regulator activity#GO:0098772;protein kinase regulator activity#GO:0019887;kinase inhibitor activity#GO:0019210;enzyme inhibitor activity#GO:0004857 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=11526|UniProtKB=P25103 P25103 TACR1 PTHR46925:SF4 G-PROTEIN COUPLED RECEPTOR TKR-1-RELATED SUBSTANCE-P RECEPTOR transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;neuropeptide receptor activity#GO:0008188;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;molecular transducer activity#GO:0060089 regulation of cell motility#GO:2000145;positive regulation of locomotion#GO:0040017;regulation of microtubule-based process#GO:0032886;regulation of cellular process#GO:0050794;regulation of microtubule-based movement#GO:0060632;regulation of reproductive process#GO:2000241;regulation of locomotion#GO:0040012;biological regulation#GO:0065007;positive regulation of cell motility#GO:2000147;positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789;positive regulation of cellular process#GO:0048522 cilium#GO:0005929;9+2 motile cilium#GO:0097729;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;cell periphery#GO:0071944;organelle#GO:0043226;motile cilium#GO:0031514;sperm flagellum#GO:0036126;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025 G-protein coupled receptor#PC00021 CCKR signaling map#P06959>TACR1#G07279;CCKR signaling map#P06959>TACR1#G06985 HUMAN|HGNC=23061|UniProtKB=O95045 O95045 UPP2 PTHR43691:SF8 URIDINE PHOSPHORYLASE URIDINE PHOSPHORYLASE 2 glycosyltransferase activity#GO:0016757;pentosyltransferase activity#GO:0016763;transferase activity#GO:0016740;catalytic activity#GO:0003824 glycosyl compound catabolic process#GO:1901658;nucleobase-containing compound catabolic process#GO:0034655;cellular process#GO:0009987;pyrimidine-containing compound metabolic process#GO:0072527;carbohydrate derivative metabolic process#GO:1901135;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;primary metabolic process#GO:0044238;nucleobase-containing small molecule catabolic process#GO:0034656;nucleoside metabolic process#GO:0009116;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;small molecule catabolic process#GO:0044282;carbohydrate derivative catabolic process#GO:1901136;nucleoside catabolic process#GO:0009164 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 metabolite interconversion enzyme#PC00262;nucleotide kinase#PC00172 Salvage pyrimidine ribonucleotides#P02775>Uridine phosphorylase#P03152 HUMAN|HGNC=23595|UniProtKB=Q5THJ4 Q5THJ4 VPS13D PTHR16166:SF141 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13 INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13D molecular carrier activity#GO:0140104;lipid carrier activity#GO:0005319;transporter activity#GO:0005215;phospholipid transfer activity#GO:0120014;lipid transfer activity#GO:0120013 lipid transport#GO:0006869;macroautophagy#GO:0016236;mitochondrion organization#GO:0007005;membrane organization#GO:0061024;organelle organization#GO:0006996;macromolecule localization#GO:0033036;cellular process#GO:0009987;autophagy#GO:0006914;intermembrane lipid transfer#GO:0120009;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;transport#GO:0006810;catabolic process#GO:0009056;cellular component organization#GO:0016043;localization#GO:0051179;process utilizing autophagic mechanism#GO:0061919;lipid localization#GO:0010876 cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;endosome membrane#GO:0010008;outer membrane#GO:0019867;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;organelle envelope#GO:0031967;vesicle#GO:0031982;mitochondrion#GO:0005739;mitochondrial outer membrane#GO:0005741;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;organelle outer membrane#GO:0031968;cytoplasm#GO:0005737;membrane#GO:0016020;vesicle membrane#GO:0012506;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966 membrane traffic protein#PC00150 HUMAN|HGNC=19240|UniProtKB=Q86SQ3 Q86SQ3 ADGRE4P PTHR12011:SF433 ADHESION G-PROTEIN COUPLED RECEPTOR ADHESION G PROTEIN-COUPLED RECEPTOR E4P-RELATED molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=30406|UniProtKB=P83110 P83110 HTRA3 PTHR22939:SF14 SERINE PROTEASE FAMILY S1C HTRA-RELATED SERINE PROTEASE HTRA3 catalytic activity#GO:0003824;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;serine-type peptidase activity#GO:0008236;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787 positive regulation of programmed cell death#GO:0043068;regulation of cellular process#GO:0050794;cell death#GO:0008219;regulation of biological process#GO:0050789;programmed cell death#GO:0012501;primary metabolic process#GO:0044238;regulation of programmed cell death#GO:0043067;protein metabolic process#GO:0019538;proteolysis#GO:0006508;biological regulation#GO:0065007;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of apoptotic process#GO:0043065;macromolecule metabolic process#GO:0043170;regulation of apoptotic process#GO:0042981;metabolic process#GO:0008152 protease#PC00190;serine protease#PC00203 HUMAN|HGNC=24979|UniProtKB=Q53T59 Q53T59 HS1BP3 PTHR14431:SF1 HCLS1-BINDING PROTEIN 3 HCLS1-BINDING PROTEIN 3 HUMAN|HGNC=15492|UniProtKB=Q9HCJ1 Q9HCJ1 ANKH PTHR28384:SF1 PROGRESSIVE ANKYLOSIS PROTEIN HOMOLOG MINERALIZATION REGULATOR ANKH transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;secondary active transmembrane transporter activity#GO:0015291;phosphate transmembrane transporter activity#GO:0005315;active transmembrane transporter activity#GO:0022804 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HUMAN|HGNC=990|UniProtKB=P10415 P10415 BCL2 PTHR11256:SF11 BCL-2 RELATED APOPTOSIS REGULATOR BCL-2 channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cell death#GO:0008219;programmed cell death#GO:0012501;regulation of cellular process#GO:0050794;DNA damage response#GO:0006974;negative regulation of cellular process#GO:0048523;apoptotic signaling pathway#GO:0097190;positive regulation of cellular process#GO:0048522;biological regulation#GO:0065007;negative regulation of apoptotic process#GO:0043066;cellular response to stress#GO:0033554;intrinsic apoptotic signaling pathway#GO:0097193;regulation of biological process#GO:0050789;apoptotic process#GO:0006915;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;cellular component organization#GO:0016043;signaling#GO:0023052;extrinsic apoptotic signaling pathway#GO:0097191;response to stimulus#GO:0050896;release of cytochrome c from mitochondria#GO:0001836;positive regulation of programmed cell death#GO:0043068;regulation of apoptotic process#GO:0042981;cell surface receptor signaling pathway#GO:0007166;positive regulation of apoptotic process#GO:0043065;cellular component organization or biogenesis#GO:0071840;positive regulation of biological process#GO:0048518;negative regulation of programmed cell death#GO:0043069;signal transduction#GO:0007165;cellular process#GO:0009987;organelle organization#GO:0006996;intrinsic apoptotic signaling pathway in response to DNA damage#GO:0008630;response to stress#GO:0006950;mitochondrion organization#GO:0007005;apoptotic mitochondrial changes#GO:0008637 outer membrane#GO:0019867;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle envelope#GO:0031967;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;mitochondrial outer membrane#GO:0005741;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane#GO:0016020;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;organelle outer membrane#GO:0031968;cytoplasm#GO:0005737 Apoptosis signaling pathway#P00006>Bcl-2#P00270;Oxidative stress response#P00046>Bcl-2#P01123;CCKR signaling map#P06959>BCL2#P07059 HUMAN|HGNC=29207|UniProtKB=Q8N1G4 Q8N1G4 LRRC47 PTHR10947:SF3 PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47 LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47 catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098;ligase activity#GO:0016874;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640 translation#GO:0006412;protein metabolic process#GO:0019538;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;protein biosynthetic process#GO:0160307;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;macromolecule metabolic process#GO:0043170;amino acid activation#GO:0043038;tRNA aminoacylation for protein translation#GO:0006418;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;tRNA aminoacylation#GO:0043039;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;gene expression#GO:0010467 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494 translational protein#PC00263;aminoacyl-tRNA synthetase#PC00047 HUMAN|HGNC=7542|UniProtKB=Q9BRK3 Q9BRK3 MXRA8 PTHR44793:SF1 MATRIX REMODELING-ASSOCIATED PROTEIN 8 MATRIX REMODELING-ASSOCIATED PROTEIN 8 cellular developmental process#GO:0048869;cell differentiation#GO:0030154;cellular process#GO:0009987;developmental process#GO:0032502 cell surface#GO:0009986;cellular anatomical structure#GO:0110165 HUMAN|HGNC=18762|UniProtKB=Q495M3 Q495M3 SLC36A2 PTHR22950:SF185 AMINO ACID TRANSPORTER PROTON-COUPLED AMINO ACID TRANSPORTER 2 glycine transmembrane transporter activity#GO:0015187;active transmembrane transporter activity#GO:0022804;L-amino acid transmembrane transporter activity#GO:0015179;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;neutral L-amino acid transmembrane transporter activity#GO:0015175;secondary active transmembrane transporter activity#GO:0015291;amino acid transmembrane transporter activity#GO:0015171;proton transmembrane transporter activity#GO:0015078;monoatomic cation transmembrane transporter activity#GO:0008324;carboxylic acid transmembrane transporter activity#GO:0046943;symporter activity#GO:0015293;solute:proton symporter activity#GO:0015295 monoatomic ion transport#GO:0006811;neutral amino acid transport#GO:0015804;amino acid transmembrane transport#GO:0003333;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;glycine transport#GO:0015816;carboxylic acid transmembrane transport#GO:1905039;establishment of localization#GO:0051234;proton transmembrane transport#GO:1902600;carboxylic acid transport#GO:0046942;transport#GO:0006810;amino acid transport#GO:0006865;organic acid transport#GO:0015849;alanine transport#GO:0032328;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;cellular process#GO:0009987;nitrogen compound transport#GO:0071705;L-amino acid transport#GO:0015807 organelle#GO:0043226;cellular anatomical structure#GO:0110165;vacuole#GO:0005773;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;vacuolar membrane#GO:0005774;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 secondary carrier transporter#PC00258;amino acid transporter#PC00046 HUMAN|HGNC=12266|UniProtKB=O43280 O43280 TREH PTHR23403:SF1 TREHALASE TREHALASE hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 carbohydrate metabolic process#GO:0005975;catabolic process#GO:0009056;oligosaccharide catabolic process#GO:0009313;cellular process#GO:0009987;primary metabolic process#GO:0044238;oligosaccharide metabolic process#GO:0009311;carbohydrate catabolic process#GO:0016052;metabolic process#GO:0008152 HUMAN|HGNC=22516|UniProtKB=P0C5Y9 P0C5Y9 H2AB1 PTHR23430:SF23 HISTONE H2A HISTONE H2A-BBD TYPE 1-RELATED structural molecule activity#GO:0005198 negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;epigenetic regulation of gene expression#GO:0040029;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;cellular component assembly#GO:0022607;negative regulation of biosynthetic process#GO:0009890;chromatin organization#GO:0006325;biological regulation#GO:0065007;heterochromatin organization#GO:0070828;negative regulation of cellular process#GO:0048523;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;negative regulation of gene expression, epigenetic#GO:0045814;regulation of gene expression#GO:0010468;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;heterochromatin formation#GO:0031507;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338 chromosome#GO:0005694;chromatin#GO:0000785;nucleus#GO:0005634;protein-DNA complex#GO:0032993;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;nucleosome#GO:0000786;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=13746|UniProtKB=Q9C0B6 Q9C0B6 BRINP2 PTHR15564:SF8 MACPF DOMAIN-CONTAINING PROTEIN BMP_RETINOIC ACID-INDUCIBLE NEURAL-SPECIFIC PROTEIN 2 cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;nervous system development#GO:0007399;response to lipid#GO:0033993;cellular response to lipid#GO:0071396;response to chemical#GO:0042221;neuron differentiation#GO:0030182;multicellular organism development#GO:0007275;negative regulation of cell cycle#GO:0045786;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of cell cycle#GO:0051726;cell differentiation#GO:0030154;response to stimulus#GO:0050896;central nervous system development#GO:0007417;response to oxygen-containing compound#GO:1901700;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cellular response to chemical stimulus#GO:0070887;negative regulation of mitotic cell cycle#GO:0045930;regulation of mitotic cell cycle#GO:0007346;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;central nervous system neuron differentiation#GO:0021953;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;system development#GO:0048731;anatomical structure development#GO:0048856 dendritic tree#GO:0097447;dendrite#GO:0030425;intracellular anatomical structure#GO:0005622;cell body#GO:0044297;neuron projection#GO:0043005;neuronal cell body#GO:0043025;cell projection#GO:0042995;somatodendritic compartment#GO:0036477;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=11218|UniProtKB=Q9NS26 Q9NS26 SPANXA1 PTHR23425:SF16 NUCLEOPORIN AMO1-LIKE SPERM PROTEIN ASSOCIATED WITH THE NUCLEUS ON THE X CHROMOSOME A-RELATED transporter#PC00227 HUMAN|HGNC=29034|UniProtKB=O43313 O43313 ATMIN PTHR46664:SF2 ATM INTERACTOR ATM INTERACTOR DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=18908|UniProtKB=Q9BYR4 Q9BYR4 KRTAP4-3 PTHR23262:SF252 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 4-3 structural protein#PC00211 HUMAN|HGNC=29500|UniProtKB=Q8N0W3 Q8N0W3 FCSK PTHR32463:SF0 L-FUCOSE KINASE L-FUCOSE KINASE catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773 organophosphate biosynthetic process#GO:0090407;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative biosynthetic process#GO:1901137;nucleoside phosphate biosynthetic process#GO:1901293;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;organophosphate metabolic process#GO:0019637;nucleotide-sugar metabolic process#GO:0009225;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058 transferase#PC00220;kinase#PC00137 HUMAN|HGNC=28167|UniProtKB=Q9BS34 Q9BS34 ZNF670 PTHR24377:SF878 IP01015P-RELATED ZINC FINGER PROTEIN 670 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=20115|UniProtKB=Q6Q0C1 Q6Q0C1 SLC25A47 PTHR45624:SF3 MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED SOLUTE CARRIER FAMILY 25 MEMBER 47 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739 transporter#PC00227 HUMAN|HGNC=12863|UniProtKB=Q9Y6Q3 Q9Y6Q3 ZFP37 PTHR24381:SF390 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 37 HOMOLOG transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=10726|UniProtKB=O95025 O95025 SEMA3D PTHR11036:SF36 SEMAPHORIN SEMAPHORIN-3D protein binding#GO:0005515;molecular function activator activity#GO:0140677;binding#GO:0005488;signaling receptor binding#GO:0005102;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545 mesenchyme development#GO:0060485;neurogenesis#GO:0022008;positive regulation of locomotion#GO:0040017;response to external stimulus#GO:0009605;neuron projection guidance#GO:0097485;cellular developmental process#GO:0048869;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;regulation of cell migration#GO:0030334;regulation of locomotion#GO:0040012;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;tissue development#GO:0009888;cell migration#GO:0016477;neural crest cell development#GO:0014032;multicellular organismal process#GO:0032501;positive regulation of cell migration#GO:0030335;positive regulation of cellular process#GO:0048522;axon guidance#GO:0007411;stem cell differentiation#GO:0048863;axon development#GO:0061564;system development#GO:0048731;anatomical structure development#GO:0048856;regulation of cell motility#GO:2000145;cell communication#GO:0007154;chemotaxis#GO:0006935;stem cell development#GO:0048864;locomotion#GO:0040011;regulation of cellular process#GO:0050794;cell motility#GO:0048870;cellular response to stimulus#GO:0051716;cell projection morphogenesis#GO:0048858;animal organ development#GO:0048513;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cell surface receptor signaling pathway#GO:0007166;plasma membrane bounded cell projection morphogenesis#GO:0120039;mesenchymal cell differentiation#GO:0048762;neural crest cell differentiation#GO:0014033;neuron differentiation#GO:0030182;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;response to chemical#GO:0042221;taxis#GO:0042330;neural crest cell migration#GO:0001755;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;neuron projection development#GO:0031175;neuron development#GO:0048666;axonogenesis#GO:0007409;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;signaling#GO:0023052;cell morphogenesis#GO:0000902;response to stimulus#GO:0050896;cell projection organization#GO:0030030;cell differentiation#GO:0030154;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;positive regulation of cell motility#GO:2000147 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;extracellular region#GO:0005576;membrane#GO:0016020 membrane-bound signaling molecule#PC00152 HUMAN|Ensembl=ENSG00000283465.4|UniProtKB=A0A1B0GVY7 A0A1B0GVY7 PTHR10881:SF62 GOLGIN SUBFAMILY A MEMBER-RELATED GOLGIN SUBFAMILY A CONSERVED DOMAIN-CONTAINING PROTEIN-RELATED organelle organization#GO:0006996;cellular component organization#GO:0016043;Golgi organization#GO:0007030;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;endomembrane system organization#GO:0010256 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;Golgi stack#GO:0005795;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;cis-Golgi network#GO:0005801;organelle membrane#GO:0031090;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;Golgi cisterna#GO:0031985;endomembrane system#GO:0012505;Golgi cis cisterna#GO:0000137;cytoplasm#GO:0005737 membrane traffic protein#PC00150 HUMAN|HGNC=21226|UniProtKB=Q9ULH4 Q9ULH4 LRFN2 PTHR45842:SF6 SYNAPTIC ADHESION-LIKE MOLECULE SALM LEUCINE-RICH REPEAT AND FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN 2 synapse#GO:0045202;cellular anatomical structure#GO:0110165;asymmetric synapse#GO:0032279;organelle#GO:0043226;postsynapse#GO:0098794;postsynaptic density membrane#GO:0098839;postsynaptic density#GO:0014069;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;plasma membrane#GO:0005886;neuron to neuron synapse#GO:0098984;postsynaptic specialization#GO:0099572;cell surface#GO:0009986;plasma membrane region#GO:0098590;cell periphery#GO:0071944;membrane#GO:0016020;cell junction#GO:0030054;synaptic membrane#GO:0097060 immunoglobulin superfamily cell adhesion molecule#PC00125;cell adhesion molecule#PC00069 HUMAN|HGNC=33869|UniProtKB=Q6ZMN8 Q6ZMN8 CCNI2 PTHR10177:SF57 CYCLINS CYCLIN-I2 cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;cyclin-dependent protein kinase regulator activity#GO:0019914;protein kinase regulator activity#GO:0019887;enzyme regulator activity#GO:0030234 mitotic cell cycle#GO:0000278;cell cycle phase transition#GO:0044770;cell cycle#GO:0007049;cell cycle G1/S phase transition#GO:0044843;cell cycle process#GO:0022402;cellular process#GO:0009987;mitotic cell cycle process#GO:1903047;mitotic cell cycle phase transition#GO:0044772;G1/S transition of mitotic cell cycle#GO:0000082 catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex#GO:1990234;transferase complex, transferring phosphorus-containing groups#GO:0061695;membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554;intracellular anatomical structure#GO:0005622;protein kinase complex#GO:1902911;nucleus#GO:0005634;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 kinase activator#PC00138 HUMAN|HGNC=12191|UniProtKB=A0A087WV62 A0A087WV62 TRBV16 PTHR23268:SF24 T-CELL RECEPTOR BETA CHAIN T CELL RECEPTOR BETA VARIABLE 16 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=21326|UniProtKB=P84550 P84550 SKOR1 PTHR10005:SF8 SKI ONCOGENE-RELATED SKI FAMILY TRANSCRIPTIONAL COREPRESSOR 1 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;protein binding#GO:0005515;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of cell communication#GO:0010648;negative regulation of DNA-templated transcription#GO:0045892;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;negative regulation of signal transduction#GO:0009968;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of cell communication#GO:0010646;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;regulation of signal transduction#GO:0009966;regulation of cellular response to growth factor stimulus#GO:0090287;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of response to stimulus#GO:0048585;negative regulation of macromolecule metabolic process#GO:0010605;regulation of BMP signaling pathway#GO:0030510;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of BMP signaling pathway#GO:0030514;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HUMAN|HGNC=23573|UniProtKB=Q9Y6X9 Q9Y6X9 MORC2 PTHR23337:SF7 ZINC FINGER CW-TYPE COILED-COIL DOMAIN PROTEIN 1 ATPASE MORC2 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=25600|UniProtKB=Q9NV64 Q9NV64 TMEM39A PTHR12995:SF3 FI21814P1 TRANSMEMBRANE PROTEIN 39A regulation of catabolic process#GO:0009894;negative regulation of autophagy#GO:0010507;regulation of macroautophagy#GO:0016241;negative regulation of cellular process#GO:0048523;regulation of autophagosome maturation#GO:1901096;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of protein-containing complex disassembly#GO:0043244;negative regulation of macroautophagy#GO:0016242;regulation of organelle assembly#GO:1902115;negative regulation of protein-containing complex disassembly#GO:0043242;negative regulation of catabolic process#GO:0009895;regulation of autophagosome assembly#GO:2000785;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of cellular component biogenesis#GO:0044087;negative regulation of metabolic process#GO:0009892;negative regulation of cellular component organization#GO:0051129;negative regulation of organelle organization#GO:0010639;regulation of autophagy#GO:0010506;negative regulation of biological process#GO:0048519;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789 organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;endoplasmic reticulum membrane#GO:0005789;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020 HUMAN|HGNC=9250|UniProtKB=Q8ND30 Q8ND30 PPFIBP2 PTHR12587:SF18 LAR INTERACTING PROTEIN LIP -RELATED PROTEIN LIPRIN-BETA-2 structural molecule activity#GO:0005198;protein complex scaffold activity#GO:0140378 cell junction organization#GO:0034330;cellular component organization or biogenesis#GO:0071840;neuromuscular junction development#GO:0007528;cellular component organization#GO:0016043;cellular process#GO:0009987;synapse organization#GO:0050808 presynaptic active zone#GO:0048786;cellular anatomical structure#GO:0110165;synapse#GO:0045202;cell junction#GO:0030054;presynapse#GO:0098793 scaffold/adaptor protein#PC00226 HUMAN|HGNC=29273|UniProtKB=Q9P2D3 Q9P2D3 HEATR5B PTHR21663:SF2 HYPOTHETICAL HEAT DOMAIN-CONTAINING HEAT REPEAT-CONTAINING PROTEIN 5B transport#GO:0006810;intracellular transport#GO:0046907;endosomal transport#GO:0016197;intracellular protein localization#GO:0008104;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;retrograde transport, endosome to Golgi#GO:0042147;macromolecule localization#GO:0033036;cytosolic transport#GO:0016482;vesicle-mediated transport#GO:0016192 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endocytic vesicle#GO:0030139;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=17070|UniProtKB=Q9UH65 Q9UH65 SWAP70 PTHR14383:SF6 SWAP-70 RECOMBINASE SWITCH-ASSOCIATED PROTEIN 70 guanyl-nucleotide exchange factor activity#GO:0005085;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;signaling#GO:0023052;intracellular signaling cassette#GO:0141124;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;Rho protein signal transduction#GO:0007266;intracellular signal transduction#GO:0035556 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;membrane#GO:0016020;actin cytoskeleton#GO:0015629;nucleus#GO:0005634;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HUMAN|HGNC=24274|UniProtKB=Q9Y5J1 Q9Y5J1 UTP18 PTHR18359:SF2 WD-REPEAT PROTEIN-RELATED U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 18 HOMOLOG metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;ribosomal small subunit biogenesis#GO:0042274;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;cellular component biogenesis#GO:0044085;endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000479;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000480;gene expression#GO:0010467;biosynthetic process#GO:0009058;maturation of SSU-rRNA#GO:0030490;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;ribonucleoprotein complex biogenesis#GO:0022613 intracellular organelle#GO:0043229;nucleolus#GO:0005730;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;preribosome#GO:0030684;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;small-subunit processome#GO:0032040;organelle lumen#GO:0043233;90S preribosome#GO:0030686;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991 HUMAN|HGNC=23190|UniProtKB=Q9BT49 Q9BT49 THAP7 PTHR47502:SF1 THAP DOMAIN-CONTAINING PROTEIN 7 THAP DOMAIN-CONTAINING PROTEIN 7 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=31723|UniProtKB=Q24JQ0 Q24JQ0 SLC35D4 PTHR11132:SF565 SOLUTE CARRIER FAMILY 35 UDP-N-ACETYLGLUCOSAMINE TRANSPORTER SLC35D4 nucleotide-sugar transmembrane transporter activity#GO:0005338;carbohydrate derivative transmembrane transporter activity#GO:1901505;organophosphate ester transmembrane transporter activity#GO:0015605;nucleobase-containing compound transmembrane transporter activity#GO:0015932;active transmembrane transporter activity#GO:0022804;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;antiporter activity#GO:0015297 cellular process#GO:0009987;transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085 organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;membrane#GO:0016020 transporter#PC00227;secondary carrier transporter#PC00258 HUMAN|HGNC=12122|UniProtKB=A0A0B4J276 A0A0B4J276 TRAV25 PTHR19433:SF80 T-CELL RECEPTOR ALPHA CHAIN V REGION-RELATED T CELL RECEPTOR ALPHA VARIABLE 25 response to stimulus#GO:0050896;response to other organism#GO:0051707;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to external stimulus#GO:0009605;response to bacterium#GO:0009617;response to biotic stimulus#GO:0009607 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=11051|UniProtKB=Q9Y345 Q9Y345 SLC6A5 PTHR11616:SF241 SODIUM/CHLORIDE DEPENDENT TRANSPORTER SODIUM- AND CHLORIDE-DEPENDENT GLYCINE TRANSPORTER 2 carboxylic acid transmembrane transporter activity#GO:0046943;solute:sodium symporter activity#GO:0015370;amino acid:sodium symporter activity#GO:0005283;neutral L-amino acid transmembrane transporter activity#GO:0015175;transmembrane transporter activity#GO:0022857;solute:monoatomic cation symporter activity#GO:0015294;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;symporter activity#GO:0015293;monoatomic cation transmembrane transporter activity#GO:0008324;amino acid transmembrane transporter activity#GO:0015171;secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;glycine transmembrane transporter activity#GO:0015187 carboxylic acid transmembrane transport#GO:1905039;signaling#GO:0023052;metal ion transport#GO:0030001;anterograde trans-synaptic signaling#GO:0098916;import across plasma membrane#GO:0098739;sodium ion transport#GO:0006814;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;monoatomic ion transport#GO:0006811;amino acid transmembrane transport#GO:0003333;neutral amino acid transport#GO:0015804;transmembrane transport#GO:0055085;cell communication#GO:0007154;monoatomic cation transport#GO:0006812;localization#GO:0051179;glycine transport#GO:0015816;trans-synaptic signaling#GO:0099537;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;nitrogen compound transport#GO:0071705;synaptic signaling#GO:0099536;establishment of localization#GO:0051234;import into cell#GO:0098657;organic acid transport#GO:0015849;transport#GO:0006810;amino acid transport#GO:0006865;carboxylic acid transport#GO:0046942 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 primary active transporter#PC00068 HUMAN|HGNC=29852|UniProtKB=O15049 O15049 N4BP3 PTHR32274:SF1 NEDD4-BINDING PROTEIN 3 NEDD4-BINDING PROTEIN 3 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HUMAN|HGNC=14656|UniProtKB=Q8TD84 Q8TD84 DSCAML1 PTHR10075:SF72 BASIGIN RELATED CELL ADHESION MOLECULE DSCAML1 animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502;multicellular organism development#GO:0007275;anatomical structure development#GO:0048856;system development#GO:0048731;central nervous system development#GO:0007417;multicellular organismal process#GO:0032501;nervous system development#GO:0007399 cell adhesion molecule#PC00069 De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>dUDP kinase#P02912;De novo purine biosynthesis#P02738>dADP kinase#P02907;De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>dCDP kinase#P02914;De novo pyrimidine ribonucleotides biosythesis#P02740>UDP kinase#P02923;De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>dTDP kinase#P02919 HUMAN|HGNC=28350|UniProtKB=Q9BV97 Q9BV97 ZNF747 PTHR23232:SF147 KRAB DOMAIN C2H2 ZINC FINGER ZINC FINGER PROTEIN 747 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=1319|UniProtKB=Q16581 Q16581 C3AR1 PTHR24225:SF28 CHEMOTACTIC RECEPTOR C3A ANAPHYLATOXIN CHEMOTACTIC RECEPTOR transmembrane signaling receptor activity#GO:0004888;immune receptor activity#GO:0140375;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;positive regulation of immune system process#GO:0002684;cellular process#GO:0009987;activation of immune response#GO:0002253;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;immune response-activating signaling pathway#GO:0002757;cell surface receptor signaling pathway#GO:0007166;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;response to stimulus#GO:0050896;immune response-activating cell surface receptor signaling pathway#GO:0002429;signaling#GO:0023052;cellular response to stimulus#GO:0051716;immune response-regulating signaling pathway#GO:0002764;regulation of biological process#GO:0050789;cell communication#GO:0007154;regulation of biological quality#GO:0065008;immune system process#GO:0002376;positive regulation of cytosolic calcium ion concentration#GO:0007204;G protein-coupled receptor signaling pathway#GO:0007186;phospholipase C-activating G protein-coupled receptor signaling pathway#GO:0007200;regulation of immune response#GO:0050776 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CHKR#P00854 HUMAN|HGNC=25982|UniProtKB=Q5T3I0 Q5T3I0 GPATCH4 PTHR23149:SF9 G PATCH DOMAIN CONTAINING PROTEIN G PATCH DOMAIN-CONTAINING PROTEIN 4 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634 RNA metabolism protein#PC00031 HUMAN|HGNC=10311|UniProtKB=Q02543 Q02543 RPL18A PTHR10052:SF50 60S RIBOSOMAL PROTEIN L18A LARGE RIBOSOMAL SUBUNIT PROTEIN EL20 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;cytoplasmic translation#GO:0002181;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;translation#GO:0006412;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;ribosome#GO:0005840;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625;cytosol#GO:0005829 ribosomal protein#PC00202 HUMAN|HGNC=13782|UniProtKB=Q9HCQ7 Q9HCQ7 NPVF PTHR14403:SF6 RFAMIDE PEPTIDE GONADOTROPIN INHIBITORY HORMONE PRO-FMRFAMIDE-RELATED NEUROPEPTIDE VF protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488 response to stimulus#GO:0050896;negative regulation of transport#GO:0051051;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of cell communication#GO:0010646;negative regulation of biological process#GO:0048519;negative regulation of multicellular organismal process#GO:0051241;neuropeptide signaling pathway#GO:0007218;regulation of biological process#GO:0050789;regulation of hormone levels#GO:0010817;cellular response to stimulus#GO:0051716;regulation of secretion#GO:0051046;cell communication#GO:0007154;regulation of hormone secretion#GO:0046883;regulation of secretion by cell#GO:1903530;regulation of biological quality#GO:0065008;negative regulation of cell communication#GO:0010648;negative regulation of signaling#GO:0023057;G protein-coupled receptor signaling pathway#GO:0007186;regulation of signaling#GO:0023051;biological regulation#GO:0065007;regulation of multicellular organismal process#GO:0051239;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of localization#GO:0032879;regulation of transport#GO:0051049;regulation of system process#GO:0044057;negative regulation of cellular process#GO:0048523 peptide hormone#PC00179 Gonadotropin-releasing hormone receptor pathway#P06664>RFRP-1/-3#P06828 HUMAN|HGNC=16134|UniProtKB=Q9NUB4 Q9NUB4 C20orf141 PTHR39222:SF1 MCG9903 RIKEN CDNA 1700020A23 GENE HUMAN|HGNC=15087|UniProtKB=Q8NHA4 Q8NHA4 OR2AE1 PTHR26453:SF196 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2AE1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 detection of chemical stimulus#GO:0009593;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;response to chemical#GO:0042221;response to stimulus#GO:0050896;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;sensory perception#GO:0007600;nervous system process#GO:0050877;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=53924|UniProtKB=P0DPK4 P0DPK4 NOTCH2NLC PTHR12916:SF16 CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2 NOTCH HOMOLOG 2 N-TERMINAL-LIKE PROTEIN A-RELATED protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 Notch signaling pathway#GO:0007219;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165 oxidase#PC00175;oxidoreductase#PC00176 HUMAN|HGNC=6722|UniProtKB=P50895 P50895 BCAM PTHR11973:SF17 CELL SURFACE GLYCOPROTEIN MUC18-RELATED BASAL CELL ADHESION MOLECULE membrane#GO:0016020;cell periphery#GO:0071944;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;immunoglobulin superfamily cell adhesion molecule#PC00125 HUMAN|HGNC=17297|UniProtKB=Q969K3 Q969K3 RNF34 PTHR14879:SF3 CASPASE REGULATOR, RING FINGER DOMAIN-CONTAINING E3 UBIQUITIN-PROTEIN LIGASE RNF34 transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842 modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;regulation of extrinsic apoptotic signaling pathway#GO:2001236;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of apoptotic signaling pathway#GO:2001233;negative regulation of apoptotic signaling pathway#GO:2001234;protein metabolic process#GO:0019538;negative regulation of extrinsic apoptotic signaling pathway#GO:2001237;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of response to stimulus#GO:0048585;negative regulation of apoptotic process#GO:0043066;regulation of response to stimulus#GO:0048583;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;negative regulation of cellular process#GO:0048523;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;regulation of biological process#GO:0050789;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;modification-dependent macromolecule catabolic process#GO:0043632;regulation of signaling#GO:0023051;protein catabolic process#GO:0030163;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648;cellular process#GO:0009987;negative regulation of programmed cell death#GO:0043069;negative regulation of signal transduction#GO:0009968;proteasomal protein catabolic process#GO:0010498;regulation of apoptotic process#GO:0042981;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152 cell periphery#GO:0071944;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=10045|UniProtKB=P10153 P10153 RNASE2 PTHR11437:SF62 RIBONUCLEASE NON-SECRETORY RIBONUCLEASE catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on RNA#GO:0140098;nuclease activity#GO:0004518;RNA nuclease activity#GO:0004540 defense response#GO:0006952;response to external stimulus#GO:0009605;innate immune response#GO:0045087;defense response to symbiont#GO:0140546;immune response#GO:0006955;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;response to other organism#GO:0051707;defense response to other organism#GO:0098542;response to chemical#GO:0042221;taxis#GO:0042330;defense response to bacterium#GO:0042742;chemotaxis#GO:0006935;response to bacterium#GO:0009617;immune system process#GO:0002376;defense response to Gram-positive bacterium#GO:0050830;locomotion#GO:0040011;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031;endoribonuclease#PC00094 HUMAN|HGNC=8633|UniProtKB=P40425 P40425 PBX2 PTHR11850:SF50 HOMEOBOX PROTEIN TRANSCRIPTION FACTORS PRE-B-CELL LEUKEMIA TRANSCRIPTION FACTOR 2 transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;DNA-binding transcription activator activity#GO:0001216;transcription regulator activity#GO:0140110;sequence-specific DNA binding#GO:0043565;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837 positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nucleobase-containing compound metabolic process#GO:0019219;brain development#GO:0007420;positive regulation of DNA-templated transcription#GO:0045893;multicellular organismal process#GO:0032501;developmental process#GO:0032502;sensory organ development#GO:0007423;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;visual system development#GO:0150063;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;animal organ morphogenesis#GO:0009887;regulation of cellular process#GO:0050794;embryonic organ development#GO:0048568;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;sensory system development#GO:0048880;embryo development#GO:0009790;head development#GO:0060322;nervous system development#GO:0007399;positive regulation of macromolecule metabolic process#GO:0010604;neuron differentiation#GO:0030182;positive regulation of transcription by RNA polymerase II#GO:0045944;multicellular organism development#GO:0007275;animal organ development#GO:0048513;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;cell development#GO:0048468;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;central nervous system development#GO:0007417;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;neuron development#GO:0048666;eye development#GO:0001654;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116;DNA-binding transcription factor#PC00218 HUMAN|HGNC=25671|UniProtKB=Q5TBB1 Q5TBB1 RNASEH2B PTHR13383:SF11 RIBONUCLEASE H2 SUBUNIT B RIBONUCLEASE H2 SUBUNIT B RNA catabolic process#GO:0006401;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;nucleic acid catabolic process#GO:0141188;cellular process#GO:0009987;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound catabolic process#GO:0034655;nucleobase-containing compound metabolic process#GO:0006139;catabolic process#GO:0009056 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013 endoribonuclease#PC00094;RNA metabolism protein#PC00031 HUMAN|HGNC=11604|UniProtKB=Q99593 Q99593 TBX5 PTHR11267:SF28 T-BOX PROTEIN-RELATED T-BOX TRANSCRIPTION FACTOR TBX5 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987 developmental process#GO:0032502;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;pattern specification process#GO:0007389;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;heart morphogenesis#GO:0003007;regulation of cellular process#GO:0050794;animal organ morphogenesis#GO:0009887;regulation of macromolecule metabolic process#GO:0060255;cell fate specification#GO:0001708;animal organ development#GO:0048513;multicellular organism development#GO:0007275;anatomical structure formation involved in morphogenesis#GO:0048646;cellular process#GO:0009987;heart development#GO:0007507;animal gross anatomical part developmental process#GO:0160108;cell fate commitment#GO:0045165;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;circulatory system development#GO:0072359;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154 chromosome#GO:0005694;nucleus#GO:0005634;chromatin#GO:0000785;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 immunoglobulin fold transcription factor#PC00251;Rel homology transcription factor#PC00252 HUMAN|HGNC=33895|UniProtKB=Q6S8J3 Q6S8J3 POTEE PTHR11937:SF547 ACTIN POTE ANKYRIN DOMAIN FAMILY MEMBER E-RELATED structural molecule activity#GO:0005198;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;structural constituent of cytoskeleton#GO:0005200;binding#GO:0005488;kinase binding#GO:0019900;structural constituent of synapse#GO:0098918;protein binding#GO:0005515 neuron projection morphogenesis#GO:0048812;plasma membrane bounded cell projection morphogenesis#GO:0120039;developmental process#GO:0032502;neuron differentiation#GO:0030182;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;neurogenesis#GO:0022008;cell projection morphogenesis#GO:0048858;axon development#GO:0061564;neuron projection development#GO:0031175;cellular process#GO:0009987;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;plasma membrane bounded cell projection organization#GO:0120036;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;anatomical structure development#GO:0048856;neuron development#GO:0048666;axonogenesis#GO:0007409;system development#GO:0048731;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cell motility#GO:0048870;cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell development#GO:0048468 neuron projection#GO:0043005;chromatin#GO:0000785;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;NuA4 histone acetyltransferase complex#GO:0035267;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;actin filament#GO:0005884;histone acetyltransferase complex#GO:0000123;cell junction#GO:0030054;actin cytoskeleton#GO:0015629;cell projection#GO:0042995;organelle#GO:0043226;cellular anatomical structure#GO:0110165;synapse#GO:0045202;intracellular organelle#GO:0043229;protein acetyltransferase complex#GO:0031248;acetyltransferase complex#GO:1902493;supramolecular fiber#GO:0099512;membrane#GO:0016020;H4 histone acetyltransferase complex#GO:1902562;transferase complex#GO:1990234;cytoskeleton#GO:0005856;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;chromosome#GO:0005694;plasma membrane bounded cell projection#GO:0120025;catalytic complex#GO:1902494;axon#GO:0030424;intracellular anatomical structure#GO:0005622 actin and actin related protein#PC00039 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>F-actin#P00858;Alzheimer disease-presenilin pathway#P00004>actin#P00114;Nicotinic acetylcholine receptor signaling pathway#P00044>Actin#P01090;Cytoskeletal regulation by Rho GTPase#P00016>Actin#P00512;Cadherin signaling pathway#P00012>F-actin#P00470;Huntington disease#P00029>Actin#P00807;Integrin signalling pathway#P00034>Actin#P00944 HUMAN|HGNC=20500|UniProtKB=Q9H7T0 Q9H7T0 CATSPERB PTHR14705:SF0 CATION CHANNEL SPERM-ASSOCIATED PROTEIN SUBUNIT BETA CATION CHANNEL SPERM-ASSOCIATED AUXILIARY SUBUNIT BETA cell maturation#GO:0048469;cellular developmental process#GO:0048869;spermatogenesis#GO:0007283;developmental process#GO:0032502;sperm capacitation#GO:0048240;developmental maturation#GO:0021700;male gamete generation#GO:0048232;cellular process#GO:0009987;multicellular organismal reproductive process#GO:0048609;anatomical structure development#GO:0048856;sexual reproduction#GO:0019953;spermatid development#GO:0007286;spermatid differentiation#GO:0048515;reproductive process#GO:0022414;cellular process involved in reproduction in multicellular organism#GO:0022412;cell development#GO:0048468;cell differentiation#GO:0030154;gamete generation#GO:0007276;anatomical structure maturation#GO:0071695;germ cell development#GO:0007281;developmental process involved in reproduction#GO:0003006 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;CatSper complex#GO:0036128;monoatomic ion channel complex#GO:0034702;cation channel complex#GO:0034703;transporter complex#GO:1990351;calcium channel complex#GO:0034704;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;voltage-gated calcium channel complex#GO:0005891;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cilium#GO:0005929;membrane-bounded organelle#GO:0043227;transmembrane transporter complex#GO:1902495 ion channel#PC00133 HUMAN|HGNC=10765|UniProtKB=Q15459 Q15459 SF3A1 PTHR15316:SF1 SPLICEOSOME ASSOCIATED PROTEIN 114/SWAP SPLICING FACTOR-RELATED SPLICING FACTOR 3A SUBUNIT 1 binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;mRNA splicing, via spliceosome#GO:0000398;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;mRNA cis splicing, via spliceosome#GO:0045292;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467 U2 snRNP#GO:0005686;nuclear protein-containing complex#GO:0140513;catalytic step 2 spliceosome#GO:0071013;Sm-like protein family complex#GO:0120114;nucleus#GO:0005634;small nuclear ribonucleoprotein complex#GO:0030532;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;spliceosomal snRNP complex#GO:0097525;spliceosomal complex#GO:0005681;U2-type prespliceosome#GO:0071004;intracellular membrane-bounded organelle#GO:0043231;U2-type spliceosomal complex#GO:0005684;organelle#GO:0043226;cellular anatomical structure#GO:0110165 RNA processing factor#PC00147;RNA splicing factor#PC00148 HUMAN|HGNC=28824|UniProtKB=A0A0J9YX57 A0A0J9YX57 MAGEB6B PTHR11736:SF67 MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN MELANOMA-ASSOCIATED ANTIGEN B6B negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=30114|UniProtKB=Q8NDB6 Q8NDB6 FAM156A PTHR31577:SF3 DEVELOPMENTAL PLURIPOTENCY-ASSOCIATED PROTEIN 3-RELATED PROTEIN FAM156A_FAM156B membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;nucleus#GO:0005634;organelle envelope#GO:0031967 HUMAN|HGNC=28335|UniProtKB=Q6ZMR3 Q6ZMR3 LDHAL6A PTHR43128:SF9 L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+)) L-LACTATE DEHYDROGENASE A-LIKE 6A catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614 monocarboxylic acid catabolic process#GO:0072329;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;small molecule catabolic process#GO:0044282;pyruvate metabolic process#GO:0006090;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;energy derivation by oxidation of organic compounds#GO:0015980;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;generation of precursor metabolites and energy#GO:0006091 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 dehydrogenase#PC00092;oxidoreductase#PC00176 HUMAN|HGNC=25171|UniProtKB=Q96CT7 Q96CT7 CCDC124 PTHR21680:SF0 COILED-COIL DOMAIN-CONTAINING PROTEIN 124 COILED-COIL DOMAIN-CONTAINING PROTEIN 124 transcription coactivator activity#GO:0003713;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|Ensembl=ENSG00000292228.2|UniProtKB=A0AAG2UXK7 A0AAG2UXK7 LOC124905564 PTHR14199:SF35 NEUROBLASTOMA BREAKPOINT FAMILY MEMBER 6-LIKE PROTEIN NBPF FAMILY MEMBER NBPF1-RELATED HUMAN|HGNC=2557|UniProtKB=P39880 P39880 CUX1 PTHR14043:SF4 CCAAT DISPLACEMENT PROTEIN-RELATED HOMEOBOX PROTEIN CUT-LIKE 1 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=1310|UniProtKB=Q9Y519 Q9Y519 TMEM184B PTHR23423:SF28 ORGANIC SOLUTE TRANSPORTER-RELATED TRANSMEMBRANE PROTEIN 184B transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 cellular anatomical structure#GO:0110165;membrane#GO:0016020 transporter#PC00227 HUMAN|HGNC=51506|UniProtKB=P0DUX0 P0DUX0 SPDYE10 PTHR31156:SF15 WBSCR19-LIKE PROTEIN SPEEDY PROTEIN E10-RELATED HUMAN|HGNC=389|UniProtKB=O43488 O43488 AKR7A2 PTHR43625:SF12 AFLATOXIN B1 ALDEHYDE REDUCTASE AFLATOXIN B1 ALDEHYDE REDUCTASE MEMBER 2 alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;alcohol dehydrogenase (NADP+) activity#GO:0008106;oxidoreductase activity#GO:0016491 detoxification#GO:0098754;catabolic process#GO:0009056;response to stimulus#GO:0050896;response to chemical#GO:0042221;response to toxic substance#GO:0009636;cellular process#GO:0009987;secondary metabolic process#GO:0019748;metabolic process#GO:0008152 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 reductase#PC00198;oxidoreductase#PC00176 HUMAN|HGNC=1957|UniProtKB=P32297 P32297 CHRNA3 PTHR18945:SF831 NEUROTRANSMITTER GATED ION CHANNEL NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3 channel activity#GO:0015267;molecular transducer activity#GO:0060089;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation channel activity#GO:0005261;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;ligand-gated monoatomic cation channel activity#GO:0099094;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;transmembrane transporter activity#GO:0022857;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;monoatomic cation transmembrane transporter activity#GO:0008324;postsynaptic neurotransmitter receptor activity#GO:0098960;transmembrane signaling receptor activity#GO:0004888;gated channel activity#GO:0022836;acetylcholine receptor activity#GO:0015464;signaling receptor activity#GO:0038023;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;transporter activity#GO:0005215;neurotransmitter receptor activity#GO:0030594 response to nitrogen compound#GO:1901698;monoatomic cation transport#GO:0006812;cell communication#GO:0007154;localization#GO:0051179;trans-synaptic signaling#GO:0099537;metal ion transport#GO:0030001;modulation of chemical synaptic transmission#GO:0050804;membrane depolarization#GO:0051899;regulation of cell communication#GO:0010646;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;chemical synaptic transmission#GO:0007268;establishment of localization#GO:0051234;transport#GO:0006810;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;monoatomic ion transmembrane transport#GO:0034220;synaptic transmission, cholinergic#GO:0007271;cellular response to nitrogen compound#GO:1901699;acetylcholine receptor signaling pathway#GO:0095500;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;response to oxygen-containing compound#GO:1901700;regulation of signaling#GO:0023051;cellular response to chemical stimulus#GO:0070887;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;calcium ion transport#GO:0006816;regulation of membrane potential#GO:0042391;neuromuscular synaptic transmission#GO:0007274;response to chemical#GO:0042221;regulation of trans-synaptic signaling#GO:0099177;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987;synaptic signaling#GO:0099536 transmembrane transporter complex#GO:1902495;postsynaptic membrane#GO:0045211;synapse#GO:0045202;cellular anatomical structure#GO:0110165;membrane protein complex#GO:0098796;postsynapse#GO:0098794;plasma membrane protein complex#GO:0098797;cell junction#GO:0030054;transporter complex#GO:1990351;signaling receptor complex#GO:0043235;synaptic membrane#GO:0097060;plasma membrane region#GO:0098590;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 ligand-gated ion channel#PC00141 Nicotine pharmacodynamics pathway#P06587>CHRNA3#P06595;Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086;Nicotinic acetylcholine receptor signaling pathway#P00044>alpha#P01088 HUMAN|HGNC=19708|UniProtKB=Q86WU2 Q86WU2 LDHD PTHR11748:SF111 D-LACTATE DEHYDROGENASE D-LACTATE DEHYDROGENASE, MITOCHONDRIAL heterocyclic compound binding#GO:1901363;oxidoreductase activity#GO:0016491;nucleotide binding#GO:0000166;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167;anion binding#GO:0043168;flavin adenine dinucleotide binding#GO:0050660;small molecule binding#GO:0036094;binding#GO:0005488 monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;monocarboxylic acid catabolic process#GO:0072329;small molecule catabolic process#GO:0044282;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152 mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 dehydrogenase#PC00092;oxidoreductase#PC00176 HUMAN|HGNC=30260|UniProtKB=Q9NVS9 Q9NVS9 PNPO PTHR10851:SF0 PYRIDOXINE-5-PHOSPHATE OXIDASE PYRIDOXINE-5'-PHOSPHATE OXIDASE oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 small molecule metabolic process#GO:0044281;biosynthetic process#GO:0009058;organophosphate metabolic process#GO:0019637;phosphorus metabolic process#GO:0006793;cellular process#GO:0009987;aldehyde metabolic process#GO:0006081;organophosphate biosynthetic process#GO:0090407;metabolic process#GO:0008152;pyridine-containing compound metabolic process#GO:0072524;small molecule biosynthetic process#GO:0044283 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 oxidoreductase#PC00176;oxidase#PC00175 Vitamin B6 metabolism#P02787>Pyridoxamine phosphate oxidase#P03236;Pyridoxal phosphate salvage pathway#P02770>Pyridoxamine-5-phosphate oxidase#P03120;Pyridoxal phosphate salvage pathway#P02770>Pyridoxine-5-phosphate oxidase#P03123;Pyridoxal-5-phosphate biosynthesis#P02759>Pyridoxine-5-phosphate oxidase#P03061 HUMAN|HGNC=28466|UniProtKB=Q9BT43 Q9BT43 POLR3GL PTHR15367:SF4 DNA-DIRECTED RNA POLYMERASE III DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC7-LIKE transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;RNA polymerase III complex#GO:0005666;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991 DNA-directed RNA polymerase#PC00019 HUMAN|HGNC=25174|UniProtKB=Q96CS2 Q96CS2 HAUS1 PTHR31570:SF2 HAUS AUGMIN-LIKE COMPLEX SUBUNIT 1 HAUS AUGMIN-LIKE COMPLEX SUBUNIT 1 microtubule cytoskeleton organization#GO:0000226;organelle assembly#GO:0070925;cell cycle process#GO:0022402;centrosome cycle#GO:0007098;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;cell cycle#GO:0007049;microtubule-based process#GO:0007017;microtubule organizing center organization#GO:0031023;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;chromosome segregation#GO:0007059;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;cellular process#GO:0009987;spindle assembly#GO:0051225;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;HAUS complex#GO:0070652;cytosol#GO:0005829;microtubule cytoskeleton#GO:0015630 HUMAN|HGNC=24581|UniProtKB=Q6Y2X3 Q6Y2X3 DNAJC14 PTHR44665:SF1 DNAJ HOMOLOG SUBFAMILY C MEMBER 14 DNAJ HOMOLOG SUBFAMILY C MEMBER 14 G protein-coupled receptor binding#GO:0001664;signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515 chaperone#PC00072 HUMAN|HGNC=30804|UniProtKB=Q8IZ13 Q8IZ13 FAM200C PTHR45935:SF18 PROTEIN ZBED8-RELATED PROTEIN FAM200C HUMAN|HGNC=29872|UniProtKB=Q8NET5 Q8NET5 NFAM1 PTHR35680:SF1 NFAT ACTIVATION MOLECULE 1 NFAT ACTIVATION MOLECULE 1 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 immune response-activating signaling pathway#GO:0002757;calcium-mediated signaling#GO:0019722;regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166;positive regulation of immune response#GO:0050778;antigen receptor-mediated signaling pathway#GO:0050851;positive regulation of response to stimulus#GO:0048584;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;positive regulation of immune system process#GO:0002684;cellular process#GO:0009987;B cell receptor signaling pathway#GO:0050853;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;immune system process#GO:0002376;regulation of immune response#GO:0050776;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;immune response-activating cell surface receptor signaling pathway#GO:0002429;signaling#GO:0023052;calcineurin-mediated signaling#GO:0097720;calcineurin-NFAT signaling cascade#GO:0033173;cellular response to stimulus#GO:0051716;immune response-regulating signaling pathway#GO:0002764;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;membrane raft#GO:0045121;membrane#GO:0016020;membrane microdomain#GO:0098857 HUMAN|HGNC=14055|UniProtKB=Q7Z7H8 Q7Z7H8 MRPL10 PTHR11560:SF12 39S RIBOSOMAL PROTEIN L10, MITOCHONDRIAL LARGE RIBOSOMAL SUBUNIT PROTEIN UL10M structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 metabolic process#GO:0008152;translation#GO:0006412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;biosynthetic process#GO:0009058 membraneless organelle#GO:0043228;mitochondrial large ribosomal subunit#GO:0005762;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;organellar ribosome#GO:0000313;intracellular anatomical structure#GO:0005622;mitochondrial ribosome#GO:0005761;membrane-bounded organelle#GO:0043227;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;ribosome#GO:0005840;mitochondrion#GO:0005739 ribosomal protein#PC00202;translational protein#PC00263 HUMAN|HGNC=17811|UniProtKB=Q8IY63 Q8IY63 AMOTL1 PTHR14826:SF12 ANGIOMOTIN ANGIOMOTIN-LIKE PROTEIN 1 biological regulation#GO:0065007;regulation of locomotion#GO:0040012;tube development#GO:0035295;cell migration#GO:0016477;multicellular organismal process#GO:0032501;developmental process#GO:0032502;regulation of cell migration#GO:0030334;establishment of cell polarity#GO:0030010;blood vessel development#GO:0001568;cellular response to stimulus#GO:0051716;tube morphogenesis#GO:0035239;cell motility#GO:0048870;regulation of cellular process#GO:0050794;actin cytoskeleton organization#GO:0030036;actin filament-based process#GO:0030029;system development#GO:0048731;intracellular signal transduction#GO:0035556;regulation of cell motility#GO:2000145;cell communication#GO:0007154;anatomical structure development#GO:0048856;signal transduction#GO:0007165;cellular process#GO:0009987;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;hippo signaling#GO:0035329;vasculature development#GO:0001944;anatomical structure formation involved in morphogenesis#GO:0048646;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;blood vessel morphogenesis#GO:0048514;signaling#GO:0023052;response to stimulus#GO:0050896;circulatory system development#GO:0072359;establishment or maintenance of cell polarity#GO:0007163;animal gross anatomical part developmental process#GO:0160108;angiogenesis#GO:0001525 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;plasma membrane#GO:0005886;bicellular tight junction#GO:0005923;cell periphery#GO:0071944;cell-cell junction#GO:0005911;membrane#GO:0016020;tight junction#GO:0070160;cell junction#GO:0030054;apical junction complex#GO:0043296 HUMAN|HGNC=13599|UniProtKB=Q9UKT7 Q9UKT7 FBXL3 PTHR16134:SF5 F-BOX/TPR REPEAT PROTEIN POF3 F-BOX_LRR-REPEAT PROTEIN 3 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;enzyme-substrate adaptor activity#GO:0140767;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 catabolic process#GO:0009056;response to stimulus#GO:0050896;response to light stimulus#GO:0009416;regulation of biological process#GO:0050789;modification-dependent protein catabolic process#GO:0019941;response to abiotic stimulus#GO:0009628;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;biological regulation#GO:0065007;proteasomal protein catabolic process#GO:0010498;regulation of circadian rhythm#GO:0042752;response to radiation#GO:0009314;cellular process#GO:0009987;response to external stimulus#GO:0009605;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;photoperiodism#GO:0009648;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057 nucleus#GO:0005634;cytosol#GO:0005829;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;intracellular membrane-bounded organelle#GO:0043231;SCF ubiquitin ligase complex#GO:0019005;cullin-RING ubiquitin ligase complex#GO:0031461;cellular anatomical structure#GO:0110165;organelle#GO:0043226;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ubiquitin ligase complex#GO:0000151 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=3526|UniProtKB=Q92800 Q92800 EZH1 PTHR45747:SF1 HISTONE-LYSINE N-METHYLTRANSFERASE E(Z) HISTONE-LYSINE N-METHYLTRANSFERASE EZH1 N-methyltransferase activity#GO:0008170;chromatin binding#GO:0003682;protein-lysine N-methyltransferase activity#GO:0016279;histone methyltransferase activity#GO:0042054;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;binding#GO:0005488;histone modifying activity#GO:0140993;histone H3 methyltransferase activity#GO:0140938;lysine N-methyltransferase activity#GO:0016278;protein methyltransferase activity#GO:0008276;transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of gene expression, epigenetic#GO:0045814;cellular component organization or biogenesis#GO:0071840;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;cellular component assembly#GO:0022607;heterochromatin organization#GO:0070828;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;heterochromatin formation#GO:0031507;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;chromatin organization#GO:0006325;regulation of metabolic process#GO:0019222;epigenetic regulation of gene expression#GO:0040029;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605 protein-containing complex#GO:0032991;nucleus#GO:0005634;PcG protein complex#GO:0031519;membrane-enclosed lumen#GO:0031974;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234;histone methyltransferase complex#GO:0035097;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;methyltransferase complex#GO:0034708;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 histone modifying enzyme#PC00261 HUMAN|HGNC=30502|UniProtKB=Q6UWQ5 Q6UWQ5 LYZL1 PTHR11407:SF62 LYSOZYME C LYSOZYME-LIKE PROTEIN 1-RELATED lysozyme activity#GO:0003796;hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;peptidoglycan muralytic activity#GO:0061783;catalytic activity#GO:0003824 glycosidase#PC00110 HUMAN|HGNC=24264|UniProtKB=Q9BSY9 Q9BSY9 DESI2 PTHR12378:SF6 DESUMOYLATING ISOPEPTIDASE DEUBIQUITINASE DESI2 peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;catalytic activity#GO:0003824 cysteine protease#PC00081;protease#PC00190 HUMAN|HGNC=21645|UniProtKB=Q9Y6H1 Q9Y6H1 CHCHD2 PTHR13523:SF3 COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2/NUR77 COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 2-RELATED DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;binding#GO:0005488;nucleic acid binding#GO:0003676 regulation of RNA biosynthetic process#GO:2001141;mitochondrion organization#GO:0007005;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;organelle organization#GO:0006996;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891 nucleus#GO:0005634;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=2642|UniProtKB=Q02928 Q02928 CYP4A11 PTHR24291:SF215 CYTOCHROME P450 FAMILY 4 CYTOCHROME P450 4A11-RELATED monooxygenase activity#GO:0004497;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;oxidoreductase activity#GO:0016491 arachidonate metabolic process#GO:0019369;carboxylic acid biosynthetic process#GO:0046394;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;monocarboxylic acid metabolic process#GO:0032787;small molecule metabolic process#GO:0044281;animal gross anatomical part developmental process#GO:0160108;olefinic compound metabolic process#GO:0120254;oxoacid metabolic process#GO:0043436;system development#GO:0048731;anatomical structure development#GO:0048856;cellular process#GO:0009987;kidney development#GO:0001822;long-chain fatty acid metabolic process#GO:0001676;renal system development#GO:0072001;biosynthetic process#GO:0009058;icosanoid biosynthetic process#GO:0046456;multicellular organismal process#GO:0032501;icosanoid metabolic process#GO:0006690;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;unsaturated fatty acid metabolic process#GO:0033559;developmental process#GO:0032502;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;animal organ development#GO:0048513;multicellular organism development#GO:0007275 intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262;oxygenase#PC00177 HUMAN|HGNC=6742|UniProtKB=Q8N653 Q8N653 LZTR1 PTHR46376:SF1 LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1 LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1 ubiquitin-like ligase-substrate adaptor activity#GO:1990756;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;enzyme-substrate adaptor activity#GO:0140767 regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;negative regulation of intracellular signal transduction#GO:1902532;regulation of Ras protein signal transduction#GO:0046578;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of small GTPase mediated signal transduction#GO:0051056;negative regulation of response to stimulus#GO:0048585;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007 transferase complex#GO:1990234;recycling endosome#GO:0055037;Golgi apparatus#GO:0005794;recycling endosome membrane#GO:0055038;intracellular protein-containing complex#GO:0140535;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;Cul3-RING ubiquitin ligase complex#GO:0031463;membrane#GO:0016020;vesicle membrane#GO:0012506;cytoplasm#GO:0005737;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;endosome membrane#GO:0010008;endosome#GO:0005768;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ubiquitin ligase complex#GO:0000151;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cullin-RING ubiquitin ligase complex#GO:0031461;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA-binding transcription factor#PC00218;basic leucine zipper transcription factor#PC00056 HUMAN|HGNC=15194|UniProtKB=Q8TCB6 Q8TCB6 OR51E1 PTHR26450:SF167 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 51E1 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=18811|UniProtKB=Q8NFL0 Q8NFL0 B3GNT7 PTHR11214:SF93 BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE UDP-GLCNAC:BETAGAL BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE 7 catalytic activity#GO:0003824;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;proteoglycan metabolic process#GO:0006029;metabolic process#GO:0008152;aminoglycan metabolic process#GO:0006022;glycoprotein metabolic process#GO:0009100;proteoglycan biosynthetic process#GO:0030166;biosynthetic process#GO:0009058;glycoprotein biosynthetic process#GO:0009101;aminoglycan biosynthetic process#GO:0006023;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;intracellular organelle#GO:0043229 glycosyltransferase#PC00111;transferase#PC00220 HUMAN|HGNC=7060|UniProtKB=P08493 P08493 MGP PTHR10109:SF0 MATRIX GLA PROTEIN MATRIX GLA PROTEIN cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 HUMAN|HGNC=26439|UniProtKB=Q86VL8 Q86VL8 SLC47A2 PTHR11206:SF81 MULTIDRUG RESISTANCE PROTEIN MULTIDRUG AND TOXIN EXTRUSION PROTEIN 2 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 cellular anatomical structure#GO:0110165;membrane#GO:0016020 transporter#PC00227 HUMAN|HGNC=23788|UniProtKB=Q6NUP7 Q6NUP7 PPP4R4 PTHR21467:SF0 PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 4 PPP4R4 SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 4 enzyme regulator activity#GO:0030234;phosphatase regulator activity#GO:0019208;molecular function regulator activity#GO:0098772;protein phosphatase regulator activity#GO:0019888 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;protein serine/threonine phosphatase complex#GO:0008287;catalytic complex#GO:1902494;cytosol#GO:0005829 phosphatase modulator#PC00184 HUMAN|HGNC=19161|UniProtKB=Q92502 Q92502 STARD8 PTHR12659:SF3 RHO-TYPE GTPASE ACTIVATING PROTEIN STAR-RELATED LIPID TRANSFER PROTEIN 8 enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772 regulation of signaling#GO:0023051;actin filament-based process#GO:0030029;regulation of intracellular signal transduction#GO:1902531;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;regulation of cell communication#GO:0010646;actin cytoskeleton organization#GO:0030036;regulation of Rho protein signal transduction#GO:0035023;regulation of cellular process#GO:0050794;regulation of response to stimulus#GO:0048583;regulation of small GTPase mediated signal transduction#GO:0051056;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;organelle organization#GO:0006996;regulation of signal transduction#GO:0009966;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007 G-protein modulator#PC00022;GTPase-activating protein#PC00257 PDGF signaling pathway#P00047>Rho#P01174 HUMAN|HGNC=15100|UniProtKB=Q8NGS8 Q8NGS8 OR13C5 PTHR26453:SF121 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 13C5 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 detection of chemical stimulus#GO:0009593;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;response to chemical#GO:0042221;response to stimulus#GO:0050896;nervous system process#GO:0050877;sensory perception#GO:0007600;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=24993|UniProtKB=Q86X83 Q86X83 COMMD2 PTHR15857:SF0 COMM DOMAIN CONTAINING PROTEIN 2 COMM DOMAIN-CONTAINING PROTEIN 2 protein complex scaffold activity#GO:0140378;structural molecule activity#GO:0005198 protein-containing complex#GO:0032991 HUMAN|HGNC=34403|UniProtKB=A2RU49 A2RU49 HYKK PTHR21064:SF1 AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED HYDROXYLYSINE KINASE catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 HUMAN|HGNC=14603|UniProtKB=Q9Y222 Q9Y222 DMTF1 PTHR46380:SF2 CYCLIN-D-BINDING MYB-LIKE TRANSCRIPTION FACTOR 1 CYCLIN-D-BINDING MYB-LIKE TRANSCRIPTION FACTOR 1 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987 regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 HUMAN|HGNC=3960|UniProtKB=O14926 O14926 FSCN2 PTHR10551:SF9 FASCIN FASCIN-2 protein-containing complex binding#GO:0044877;protein binding#GO:0005515;actin filament binding#GO:0051015;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;binding#GO:0005488 actin filament-based process#GO:0030029;establishment or maintenance of cell polarity#GO:0007163;supramolecular fiber organization#GO:0097435;actin filament bundle organization#GO:0061572;actin filament bundle assembly#GO:0051017;cellular component organization#GO:0016043;cell motility#GO:0048870;actin cytoskeleton organization#GO:0030036;actin filament organization#GO:0007015;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;cell migration#GO:0016477;cellular component assembly#GO:0022607 actin cytoskeleton#GO:0015629;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 non-motor actin binding protein#PC00165 HUMAN|HGNC=29883|UniProtKB=Q8TDQ1 Q8TDQ1 CD300LF PTHR11860:SF119 POLYMERIC-IMMUNOGLOBULIN RECEPTOR CMRF35-LIKE MOLECULE 1 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 immune response-activating signaling pathway#GO:0002757;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;signal transduction#GO:0007165;positive regulation of immune system process#GO:0002684;cell communication#GO:0007154;regulation of immune response#GO:0050776;immune system process#GO:0002376;signaling#GO:0023052;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;immune response-regulating signaling pathway#GO:0002764;regulation of biological process#GO:0050789 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=4404|UniProtKB=P59768 P59768 GNG2 PTHR13809:SF25 GUANINE NUCLEOTIDE-BINDING PROTEIN GAMMA SUBUNIT GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)_G(S)_G(O) SUBUNIT GAMMA-2 GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;molecular function regulator activity#GO:0098772;ribonucleoside triphosphate phosphatase activity#GO:0017111 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165 cytoplasmic side of plasma membrane#GO:0009898;membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;extrinsic component of cytoplasmic side of plasma membrane#GO:0031234;cytoplasmic side of membrane#GO:0098562;catalytic complex#GO:1902494;side of membrane#GO:0098552;extrinsic component of plasma membrane#GO:0019897;extrinsic component of membrane#GO:0019898 heterotrimeric G-protein#PC00117 Oxytocin receptor mediated signaling pathway#P04391>G-Protein#P04534;Cortocotropin releasing factor receptor signaling pathway#P04380>G-Protein#P04458;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>G-Protein#P01085;5HT4 type receptor mediated signaling pathway#P04376>G-protein#P04430;Metabotropic glutamate receptor group III pathway#P00039>G-Protein#P01045;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>G-Protein#P01073;Opioid proopiomelanocortin pathway#P05917>G-protein#P06012;Nicotine pharmacodynamics pathway#P06587>GNG#P06590;CCKR signaling map#P06959>Gbeta/gamma#P07197;Enkephalin release#P05913>G-Protein (i)#P05974;Enkephalin release#P05913>G-Protein (s)#P05977;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Gbetagamma#P00836;Thyrotropin-releasing hormone receptor signaling pathway#P04394>G-Protein#P04584;5HT2 type receptor mediated signaling pathway#P04374>G-protein#P04416;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Ggamma#P00751;Opioid proenkephalin pathway#P05915>G-protein#P05994;Gonadotropin-releasing hormone receptor pathway#P06664>Ggamma#P06754;Histamine H1 receptor mediated signaling pathway#P04385>G-Protein#P04488;5HT1 type receptor mediated signaling pathway#P04373>G-protein#P04408;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Ggamma#P00721;Histamine H2 receptor mediated signaling pathway#P04386>G-Protein#P04490;Beta2 adrenergic receptor signaling pathway#P04378>G-Protein#P04443;Wnt signaling pathway#P00057>Ggamma#P01465;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GIRK#P00743;Beta3 adrenergic receptor signaling pathway#P04379>G-Protein#P04448;Beta1 adrenergic receptor signaling pathway#P04377>G-Protein#P04436;Opioid prodynorphin pathway#P05916>G-protein#P06002;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Ggamma#P00726;Metabotropic glutamate receptor group II pathway#P00040>G-protein#P01047 HUMAN|HGNC=7870|UniProtKB=O94818 O94818 NOL4 PTHR12449:SF17 DEATH DOMAIN-CONTAINING PROTEIN NUCLEOLAR PROTEIN 4 HUMAN|HGNC=27446|UniProtKB=Q494R4 Q494R4 DRC12 PTHR28656:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 153 DYNEIN REGULATORY COMPLEX PROTEIN 12 HUMAN|HGNC=21685|UniProtKB=Q6YHK3 Q6YHK3 CD109 PTHR11412:SF136 MACROGLOBULIN / COMPLEMENT CD109 ANTIGEN enzyme inhibitor activity#GO:0004857;endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414;peptidase regulator activity#GO:0061134;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678 response to stress#GO:0006950;response to biotic stimulus#GO:0009607;defense response to symbiont#GO:0140546;immune response#GO:0006955;defense response to other organism#GO:0098542;response to stimulus#GO:0050896;response to other organism#GO:0051707;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;immune system process#GO:0002376;innate immune response#GO:0045087;defense response#GO:0006952;response to external stimulus#GO:0009605 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;extracellular region#GO:0005576;catalytic complex#GO:1902494;extracellular protein-containing complex#GO:0140392 protease inhibitor#PC00191 HUMAN|HGNC=27846|UniProtKB=P0DKV0 P0DKV0 SPATA31C1 PTHR21859:SF44 ACROSOME-SPECIFIC PROTEIN SPERMATOGENESIS-ASSOCIATED PROTEIN 31C1-RELATED HUMAN|HGNC=4557|UniProtKB=O75715 O75715 GPX5 PTHR11592:SF127 GLUTATHIONE PEROXIDASE EPIDIDYMAL SECRETORY GLUTATHIONE PEROXIDASE oxidoreductase activity, acting on peroxide as acceptor#GO:0016684;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;antioxidant activity#GO:0016209;peroxidase activity#GO:0004601 response to stress#GO:0006950;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cellular response to oxidative stress#GO:0034599;response to stimulus#GO:0050896;response to chemical#GO:0042221;cellular response to chemical stimulus#GO:0070887;cellular response to stress#GO:0033554;response to oxidative stress#GO:0006979;cellular response to chemical stress#GO:0062197 oxidoreductase#PC00176;peroxidase#PC00180 HUMAN|HGNC=6030|UniProtKB=Q01113 Q01113 IL9R PTHR23037:SF29 CYTOKINE RECEPTOR INTERLEUKIN-9 RECEPTOR cytokine receptor activity#GO:0004896;cytokine binding#GO:0019955;signaling receptor activity#GO:0038023;immune receptor activity#GO:0140375;transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488;molecular transducer activity#GO:0060089;protein binding#GO:0005515;growth factor binding#GO:0019838 lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;cell communication#GO:0007154;response to peptide#GO:1901652;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;immune system process#GO:0002376;cytokine-mediated signaling pathway#GO:0019221;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;cellular response to stimulus#GO:0051716;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;immune effector process#GO:0002252;cell surface receptor signaling pathway#GO:0007166;response to cytokine#GO:0034097;response to chemical#GO:0042221;adaptive immune response#GO:0002250;interleukin-9-mediated signaling pathway#GO:0038113;biological regulation#GO:0065007;cellular process#GO:0009987;immune response#GO:0006955;signal transduction#GO:0007165 cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;plasma membrane#GO:0005886;membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=29179|UniProtKB=Q96AY4 Q96AY4 TTC28 PTHR10098:SF108 RAPSYN-RELATED TETRATRICOPEPTIDE REPEAT PROTEIN 28 scaffold/adaptor protein#PC00226 HUMAN|HGNC=3824|UniProtKB=Q05932 Q05932 FPGS PTHR11136:SF5 FOLYLPOLYGLUTAMATE SYNTHASE-RELATED FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL ligase activity, forming carbon-nitrogen bonds#GO:0016879;ligase activity#GO:0016874;catalytic activity#GO:0003824 pteridine-containing compound metabolic process#GO:0042558;folic acid-containing compound metabolic process#GO:0006760;biosynthetic process#GO:0009058;metabolic process#GO:0008152;modified amino acid metabolic process#GO:0006575;cellular process#GO:0009987 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 ligase#PC00142 Formyltetrahydrofolate biosynthesis#P02743>Dihydrofolate synthase#P02958;Tetrahydrofolate biosynthesis#P02742>Dihydrofolate synthase#P02943 HUMAN|HGNC=1005|UniProtKB=Q9BQE9 Q9BQE9 BCL7B PTHR12767:SF5 BCL7 RELATED B-CELL CLL_LYMPHOMA 7 PROTEIN FAMILY MEMBER B cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cell communication#GO:0007154 membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;chromatin#GO:0000785;nucleus#GO:0005634;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;ATPase complex#GO:1904949;catalytic complex#GO:1902494;SWI/SNF complex#GO:0016514;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;SWI/SNF superfamily-type complex#GO:0070603;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=24094|UniProtKB=Q8IWT0 Q8IWT0 ZBTB8OS PTHR12682:SF12 ARCHEASE TRNA-SPLICING LIGASE-ACTIVATING FACTOR ARCHEASE intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;catalytic complex#GO:1902494 HUMAN|HGNC=11615|UniProtKB=O75764 O75764 TCEA3 PTHR11477:SF4 TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN TRANSCRIPTION ELONGATION FACTOR A PROTEIN 3 transcription regulator activity#GO:0140110;transcription elongation factor activity#GO:0003711 macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;transcription by RNA polymerase II#GO:0006366;transcription elongation by RNA polymerase II#GO:0006368;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;DNA-templated transcription elongation#GO:0006354;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 RNA metabolism protein#PC00031;general transcription factor#PC00259 HUMAN|HGNC=13008|UniProtKB=O76080 O76080 ZFAND5 PTHR10634:SF26 AN1-TYPE ZINC FINGER PROTEIN AN1-TYPE ZINC FINGER PROTEIN 5 HUMAN|HGNC=14344|UniProtKB=Q9BXJ0 Q9BXJ0 C1QTNF5 PTHR15427:SF27 EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER COMPLEMENT C1Q TUMOR NECROSIS FACTOR-RELATED PROTEIN 5 receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 macromolecule localization#GO:0033036;protein localization to extracellular region#GO:0071692;cellular process#GO:0009987;establishment of protein localization#GO:0045184;export from cell#GO:0140352;transport#GO:0006810;establishment of localization#GO:0051234;secretion#GO:0046903;localization#GO:0051179;protein secretion#GO:0009306;protein transport#GO:0015031;establishment of protein localization to extracellular region#GO:0035592;secretion by cell#GO:0032940;intracellular protein localization#GO:0008104 membrane#GO:0016020;extracellular region#GO:0005576;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HUMAN|HGNC=20793|UniProtKB=Q9H2L5 Q9H2L5 RASSF4 PTHR22738:SF4 RASSF RAS ASSOCIATION DOMAIN-CONTAINING PROTEIN 4 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell communication#GO:0007154 scaffold/adaptor protein#PC00226 HUMAN|HGNC=25560|UniProtKB=Q96P16 Q96P16 RPRD1A PTHR12460:SF2 CYCLIN-DEPENDENT KINASE INHIBITOR-RELATED PROTEIN REGULATION OF NUCLEAR PRE-MRNA DOMAIN-CONTAINING PROTEIN 1A binding#GO:0005488;enzyme binding#GO:0019899;RNA polymerase binding#GO:0070063;RNA polymerase II complex binding#GO:0000993;protein binding#GO:0005515;RNA polymerase core enzyme binding#GO:0043175 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;mRNA 3'-end processing#GO:0031124;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA 3'-end processing#GO:0031123;macromolecule metabolic process#GO:0043170 kinase inhibitor#PC00139;protein-binding activity modulator#PC00095 HUMAN|HGNC=28787|UniProtKB=Q969X0 Q969X0 RILPL2 PTHR21502:SF2 ZINC FINGER PROTEIN DZIP1 RILP-LIKE PROTEIN 2 enzyme binding#GO:0019899;binding#GO:0005488;protein binding#GO:0005515;small GTPase binding#GO:0031267 cell projection organization#GO:0030030;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782;organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031 ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;cilium#GO:0005929;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;microtubule cytoskeleton#GO:0015630;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232 non-motor microtubule binding protein#PC00166;cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=37098|UniProtKB=B2RXH2 B2RXH2 KDM4E PTHR10694:SF34 LYSINE-SPECIFIC DEMETHYLASE LYSINE-SPECIFIC DEMETHYLASE 4E catalytic activity#GO:0003824;histone demethylase activity#GO:0032452;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;protein demethylase activity#GO:0140457;catalytic activity, acting on a protein#GO:0140096;demethylase activity#GO:0032451;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;oxidoreductase activity#GO:0016491;dioxygenase activity#GO:0051213;histone modifying activity#GO:0140993 biological regulation#GO:0065007;chromatin organization#GO:0006325;chromatin remodeling#GO:0006338;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular process#GO:0009987;regulation of metabolic process#GO:0019222;cellular component organization#GO:0016043;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889 chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 histone modifying enzyme#PC00261 HUMAN|HGNC=29012|UniProtKB=O15054 O15054 KDM6B PTHR14017:SF5 LYSINE-SPECIFIC DEMETHYLASE LYSINE-SPECIFIC DEMETHYLASE 6B histone modifying activity#GO:0140993;transcription regulatory region nucleic acid binding#GO:0001067;binding#GO:0005488;sequence-specific DNA binding#GO:0043565;demethylase activity#GO:0032451;protein demethylase activity#GO:0140457;histone demethylase activity#GO:0032452;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;dioxygenase activity#GO:0051213;cis-regulatory region sequence-specific DNA binding#GO:0000987;chromatin binding#GO:0003682;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491;sequence-specific double-stranded DNA binding#GO:1990837;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;chromatin DNA binding#GO:0031490;catalytic activity#GO:0003824 circulatory system development#GO:0072359;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;anatomical structure development#GO:0048856;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;heart development#GO:0007507;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;multicellular organism development#GO:0007275;regulation of biosynthetic process#GO:0009889;animal organ development#GO:0048513;regulation of gene expression#GO:0010468;developmental process#GO:0032502 intracellular organelle lumen#GO:0070013;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;methyltransferase complex#GO:0034708;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;histone methyltransferase complex#GO:0035097;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=14975|UniProtKB=Q9Y5W9 Q9Y5W9 SNX11 PTHR46209:SF1 PX DOMAIN-CONTAINING PROTEIN SORTING NEXIN-11 phosphatidylinositol phosphate binding#GO:1901981;lipid binding#GO:0008289;binding#GO:0005488;phospholipid binding#GO:0005543 cellular component organization or biogenesis#GO:0071840;vesicle organization#GO:0016050;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987 intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 HUMAN|HGNC=3418|UniProtKB=P07814 P07814 EPRS1 PTHR43382:SF2 PROLYL-TRNA SYNTHETASE BIFUNCTIONAL GLUTAMATE_PROLINE--TRNA LIGASE ligase activity#GO:0016874;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a tRNA#GO:0140101 translation#GO:0006412;RNA metabolic process#GO:0016070;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;protein biosynthetic process#GO:0160307;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;macromolecule metabolic process#GO:0043170;amino acid activation#GO:0043038;tRNA aminoacylation for protein translation#GO:0006418;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;tRNA aminoacylation#GO:0043039;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;amino acid metabolic process#GO:0006520;gene expression#GO:0010467 catalytic complex#GO:1902494;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535 translational protein#PC00263;aminoacyl-tRNA synthetase#PC00047 Heme biosynthesis#P02746>Glutamyl-tRNA-synthetase#P02977 HUMAN|HGNC=4733|UniProtKB=Q93077 Q93077 H2AC6 PTHR23430:SF28 HISTONE H2A HISTONE H2A TYPE 1-C structural molecule activity#GO:0005198 regulation of biosynthetic process#GO:0009889;negative regulation of gene expression, epigenetic#GO:0045814;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;cellular component assembly#GO:0022607;heterochromatin organization#GO:0070828;biological regulation#GO:0065007;chromatin organization#GO:0006325;negative regulation of biosynthetic process#GO:0009890;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;epigenetic regulation of gene expression#GO:0040029;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;heterochromatin formation#GO:0031507;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;nucleosome#GO:0000786;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-DNA complex#GO:0032993;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=2014|UniProtKB=Q05315 Q05315 CLC PTHR11346:SF120 GALECTIN GALACTOSIDE-BINDING SOLUBLE LECTIN 13-RELATED binding#GO:0005488;carbohydrate binding#GO:0030246 extracellular matrix protein#PC00102 HUMAN|HGNC=17888|UniProtKB=O75575 O75575 CRCP PTHR15561:SF0 CALCITONIN GENE-RELATED PEPTIDE-RECEPTOR COMPONENT PROTEIN DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9 nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;transcription by RNA polymerase III#GO:0006383;DNA-templated transcription initiation#GO:0006352;transcription initiation at RNA polymerase III promoter#GO:0006384;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774 transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;RNA polymerase III complex#GO:0005666;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=1810|UniProtKB=Q9Y6F7 Q9Y6F7 CDY2A PTHR43684:SF6 FAMILY NOT NAMED TESTIS-SPECIFIC CHROMODOMAIN PROTEIN Y 1-RELATED transcription regulator activity#GO:0140110;histone H3 reader activity#GO:0140006;protein-macromolecule adaptor activity#GO:0030674;isomerase activity#GO:0016853;chromatin-protein adaptor activity#GO:0140463;intramolecular oxidoreductase activity#GO:0016860;histone reader activity#GO:0140566;histone H3K9me2/3 reader activity#GO:0062072;transcription coregulator activity#GO:0003712;molecular adaptor activity#GO:0060090;transcription corepressor activity#GO:0003714;catalytic activity#GO:0003824 monocarboxylic acid catabolic process#GO:0072329;male gamete generation#GO:0048232;carboxylic acid catabolic process#GO:0046395;cellular developmental process#GO:0048869;lipid modification#GO:0030258;fatty acid metabolic process#GO:0006631;fatty acid beta-oxidation#GO:0006635;lipid metabolic process#GO:0006629;developmental process#GO:0032502;spermatogenesis#GO:0007283;catabolic process#GO:0009056;reproductive process#GO:0022414;primary metabolic process#GO:0044238;developmental process involved in reproduction#GO:0003006;germ cell development#GO:0007281;lipid oxidation#GO:0034440;anatomical structure development#GO:0048856;multicellular organismal reproductive process#GO:0048609;spermatid development#GO:0007286;sexual reproduction#GO:0019953;cellular process#GO:0009987;lipid catabolic process#GO:0016042;metabolic process#GO:0008152;fatty acid oxidation#GO:0019395;gamete generation#GO:0007276;small molecule metabolic process#GO:0044281;cell differentiation#GO:0030154;cell development#GO:0048468;cellular process involved in reproduction in multicellular organism#GO:0022412;small molecule catabolic process#GO:0044282;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;fatty acid catabolic process#GO:0009062;spermatid differentiation#GO:0048515;oxoacid metabolic process#GO:0043436 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;peroxisomal matrix#GO:0005782;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microbody#GO:0042579;nucleus#GO:0005634;peroxisome#GO:0005777;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233 HUMAN|HGNC=9215|UniProtKB=P20265 P20265 POU3F2 PTHR11636:SF115 POU DOMAIN POU DOMAIN, CLASS 3, TRANSCRIPTION FACTOR 2 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789 nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=13481|UniProtKB=Q9H1C4 Q9H1C4 UNC93B1 PTHR46744:SF1 PROTEIN UNC-93 HOMOLOG B1 PROTEIN UNC-93 HOMOLOG B1 protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488 cellular response to stimulus#GO:0051716;innate immune response-activating signaling pathway#GO:0002758;intracellular receptor signaling pathway#GO:0030522;regulation of response to biotic stimulus#GO:0002831;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of immune response#GO:0050776;regulation of defense response#GO:0031347;intracellular signal transduction#GO:0035556;localization#GO:0051179;cell communication#GO:0007154;positive regulation of innate immune response#GO:0045089;macromolecule localization#GO:0033036;activation of innate immune response#GO:0002218;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;positive regulation of immune response#GO:0050778;positive regulation of defense response#GO:0031349;transport#GO:0006810;regulation of response to stimulus#GO:0048583;regulation of response to stress#GO:0080134;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;positive regulation of response to biotic stimulus#GO:0002833;pattern recognition receptor signaling pathway#GO:0002221;regulation of innate immune response#GO:0045088;establishment of localization#GO:0051234;regulation of biological process#GO:0050789;immune response-regulating signaling pathway#GO:0002764;signaling#GO:0023052;response to stimulus#GO:0050896;immune system process#GO:0002376;protein transport#GO:0015031;cellular localization#GO:0051641;cytoplasmic pattern recognition receptor signaling pathway#GO:0002753;establishment of protein localization#GO:0045184;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;establishment of localization in cell#GO:0051649;activation of immune response#GO:0002253;cellular process#GO:0009987;positive regulation of immune system process#GO:0002684;regulation of response to external stimulus#GO:0032101;intracellular protein transport#GO:0006886;immune response-activating signaling pathway#GO:0002757;positive regulation of response to external stimulus#GO:0032103 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;vacuole#GO:0005773;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;lysosome#GO:0005764;lytic vacuole#GO:0000323;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768 HUMAN|HGNC=740|UniProtKB=Q9NQ33 Q9NQ33 ASCL3 PTHR13935:SF68 ACHAETE-SCUTE TRANSCRIPTION FACTOR-RELATED ACHAETE-SCUTE HOMOLOG 3 DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254 intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;intracellular anatomical structure#GO:0005622;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229 basic helix-loop-helix transcription factor#PC00055;gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HUMAN|HGNC=33776|UniProtKB=Q6ZQR2 Q6ZQR2 CFAP77 PTHR28617:SF1 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 77 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 77 structural protein#PC00211 HUMAN|HGNC=28834|UniProtKB=Q3KPI0 Q3KPI0 CEACAM21 PTHR12080:SF82 SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE CELL ADHESION MOLECULE CEACAM21 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 immune system process#GO:0002376;protein localization to cell junction#GO:1902414;localization#GO:0051179;cell communication#GO:0007154;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;immune response#GO:0006955;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052 cell junction#GO:0030054;cellular anatomical structure#GO:0110165;anchoring junction#GO:0070161;cell-cell junction#GO:0005911 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=1907|UniProtKB=O95992 O95992 CH25H PTHR11863:SF213 STEROL DESATURASE CHOLESTEROL 25-HYDROXYLASE catalytic activity#GO:0003824;steroid hydroxylase activity#GO:0008395;monooxygenase activity#GO:0004497;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;oxidoreductase activity#GO:0016491 alcohol biosynthetic process#GO:0046165;cellular process#GO:0009987;steroid metabolic process#GO:0008202;sterol biosynthetic process#GO:0016126;biosynthetic process#GO:0009058;cholesterol biosynthetic process#GO:0006695;lipid biosynthetic process#GO:0008610;lipid metabolic process#GO:0006629;cholesterol metabolic process#GO:0008203;small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152;alcohol metabolic process#GO:0006066;secondary alcohol biosynthetic process#GO:1902653;sterol metabolic process#GO:0016125;steroid biosynthetic process#GO:0006694;primary metabolic process#GO:0044238;secondary alcohol metabolic process#GO:1902652;small molecule metabolic process#GO:0044281 endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;membrane#GO:0016020;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 oxidase#PC00175 HUMAN|HGNC=26965|UniProtKB=Q8WUK0 Q8WUK0 PTPMT1 PTHR46712:SF2 PHOSPHATIDYLGLYCEROPHOSPHATASE AND PROTEIN-TYROSINE PHOSPHATASE 1 PHOSPHATIDYLGLYCEROPHOSPHATASE AND PROTEIN-TYROSINE PHOSPHATASE 1 catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739 HUMAN|HGNC=6817|UniProtKB=P21145 P21145 MAL PTHR22776:SF12 MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN MYELIN AND LYMPHOCYTE PROTEIN structural molecule activity#GO:0005198 animal gross anatomical part developmental process#GO:0160108;localization within membrane#GO:0051668;localization#GO:0051179;cellular localization#GO:0051641;anatomical structure development#GO:0048856;system development#GO:0048731;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;signaling#GO:0023052;developmental process#GO:0032502;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;myelination#GO:0042552;establishment of protein localization to membrane#GO:0090150;macromolecule localization#GO:0033036;establishment of protein localization#GO:0045184;cellular process#GO:0009987;protein insertion into membrane#GO:0051205;multicellular organismal process#GO:0032501;membrane organization#GO:0061024;biological regulation#GO:0065007;nervous system development#GO:0007399 apical part of cell#GO:0045177;membrane microdomain#GO:0098857;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;apical plasma membrane#GO:0016324;membrane#GO:0016020;membrane raft#GO:0045121;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HUMAN|HGNC=7626|UniProtKB=Q13506 Q13506 NAB1 PTHR12623:SF9 NGFI-A BINDING PROTEIN NGFI-A-BINDING PROTEIN 1 transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 Gonadotropin-releasing hormone receptor pathway#P06664>NAB#P06801 HUMAN|HGNC=29672|UniProtKB=Q8IY33 Q8IY33 MICALL2 PTHR23167:SF87 CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED MICAL-LIKE PROTEIN 2 cellular process#GO:0009987;actin filament-based process#GO:0030029;organelle organization#GO:0006996;cellular component organization#GO:0016043;cytoskeleton organization#GO:0007010;cellular component organization or biogenesis#GO:0071840;actin cytoskeleton organization#GO:0030036 scaffold/adaptor protein#PC00226 HUMAN|HGNC=8318|UniProtKB=Q9UKL2 Q9UKL2 OR52A1 PTHR26450:SF98 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 52A1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=18124|UniProtKB=Q9H244 Q9H244 P2RY12 PTHR24233:SF0 P2Y PURINOCEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR P2Y PURINOCEPTOR 12 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=24265|UniProtKB=Q9Y3E5 Q9Y3E5 PTRH2 PTHR12649:SF31 PEPTIDYL-TRNA HYDROLASE 2 PEPTIDYL-TRNA HYDROLASE 2, MITOCHONDRIAL carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a tRNA#GO:0140101;hydrolase activity#GO:0016787 regulation of apoptotic process#GO:0042981;negative regulation of cellular process#GO:0048523;positive regulation of apoptotic process#GO:0043065;positive regulation of cellular process#GO:0048522;negative regulation of programmed cell death#GO:0043069;regulation of biological process#GO:0050789;positive regulation of biological process#GO:0048518;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;biological regulation#GO:0065007;negative regulation of apoptotic process#GO:0043066;positive regulation of programmed cell death#GO:0043068;regulation of cellular process#GO:0050794 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=5383|UniProtKB=P48735 P48735 IDH2 PTHR11822:SF46 NADP-SPECIFIC ISOCITRATE DEHYDROGENASE ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL organophosphate metabolic process#GO:0019637;NADP+ metabolic process#GO:0006739;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;purine nucleotide metabolic process#GO:0006163;nicotinamide nucleotide metabolic process#GO:0046496;purine-containing compound metabolic process#GO:0072521;cellular process#GO:0009987;small molecule metabolic process#GO:0044281;nucleobase-containing compound metabolic process#GO:0006139;nucleoside phosphate metabolic process#GO:0006753;metabolic process#GO:0008152;pyridine-containing compound metabolic process#GO:0072524;nucleotide metabolic process#GO:0009117;nucleobase-containing small molecule metabolic process#GO:0055086 mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 dehydrogenase#PC00092;oxidoreductase#PC00176 HUMAN|HGNC=1503|UniProtKB=P42575 P42575 CASP2 PTHR10454:SF250 CASPASE CASPASE-2 endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;cysteine-type endopeptidase activity#GO:0004197;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824 positive regulation of neuron apoptotic process#GO:0043525;cell surface receptor signaling pathway#GO:0007166;regulation of apoptotic process#GO:0042981;DNA damage response#GO:0006974;apoptotic signaling pathway#GO:0097190;positive regulation of apoptotic process#GO:0043065;response to stress#GO:0006950;intrinsic apoptotic signaling pathway in response to DNA damage#GO:0008630;regulation of neuron apoptotic process#GO:0043523;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;biological regulation#GO:0065007;cellular response to stress#GO:0033554;intrinsic apoptotic signaling pathway#GO:0097193;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;programmed cell death#GO:0012501;regulation of programmed cell death#GO:0043067;cell death#GO:0008219;apoptotic process#GO:0006915;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;positive regulation of programmed cell death#GO:0043068;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;extrinsic apoptotic signaling pathway#GO:0097191;signaling#GO:0023052 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;protease#PC00190 HUMAN|HGNC=684|UniProtKB=Q9NR80 Q9NR80 ARHGEF4 PTHR47544:SF2 RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 4 RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 4 guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589 guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=17030|UniProtKB=Q9HCN4 Q9HCN4 GPN1 PTHR21231:SF8 XPA-BINDING PROTEIN 1-RELATED GPN-LOOP GTPASE 1 hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787 small GTPase#PC00208;G-protein#PC00020;protein-binding activity modulator#PC00095 HUMAN|HGNC=3367|UniProtKB=O75356 O75356 ENTPD5 PTHR11782:SF35 ADENOSINE/GUANOSINE DIPHOSPHATASE NUCLEOSIDE DIPHOSPHATE PHOSPHATASE ENTPD5 nucleoside diphosphate phosphatase activity#GO:0017110;hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817 organophosphate catabolic process#GO:0046434;nucleobase-containing small molecule metabolic process#GO:0055086;nucleoside diphosphate metabolic process#GO:0009132;metabolic process#GO:0008152;nucleoside phosphate catabolic process#GO:1901292;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;nucleoside phosphate metabolic process#GO:0006753;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;organophosphate metabolic process#GO:0019637;nucleobase-containing compound catabolic process#GO:0034655;cellular process#GO:0009987;nucleoside diphosphate catabolic process#GO:0009134 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 phosphatase#PC00181;nucleotide phosphatase#PC00173;hydrolase#PC00121 HUMAN|HGNC=8623|UniProtKB=P55771 P55771 PAX9 PTHR45636:SF13 PAIRED BOX PROTEIN PAX-6-RELATED-RELATED PAIRED BOX PROTEIN PAX-9 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 HUMAN|HGNC=1800|UniProtKB=Q92903 Q92903 CDS1 PTHR13773:SF16 PHOSPHATIDATE CYTIDYLYLTRANSFERASE PHOSPHATIDATE CYTIDYLYLTRANSFERASE 1 transferase activity, transferring phosphorus-containing groups#GO:0016772;nucleotidyltransferase activity#GO:0016779;transferase activity#GO:0016740;catalytic activity#GO:0003824 cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;glycerophospholipid biosynthetic process#GO:0046474;lipid metabolic process#GO:0006629;cellular component assembly#GO:0022607;glycerophospholipid metabolic process#GO:0006650;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058;cellular component biogenesis#GO:0044085;organophosphate metabolic process#GO:0019637;organelle organization#GO:0006996;lipid storage#GO:0019915;glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987;organophosphate biosynthetic process#GO:0090407;lipid droplet organization#GO:0034389;organelle assembly#GO:0070925;glycerolipid metabolic process#GO:0046486;phospholipid biosynthetic process#GO:0008654;phospholipid metabolic process#GO:0006644;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694 membrane#GO:0016020;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227 transferase#PC00220 HUMAN|HGNC=24728|UniProtKB=A2RTX5 A2RTX5 TARS3 PTHR11451:SF38 THREONINE-TRNA LIGASE THREONINE--TRNA LIGASE 2, CYTOPLASMIC catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098;ligase activity#GO:0016874;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 translation#GO:0006412;protein metabolic process#GO:0019538;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;protein biosynthetic process#GO:0160307;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;macromolecule metabolic process#GO:0043170;amino acid activation#GO:0043038;tRNA aminoacylation for protein translation#GO:0006418;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;tRNA aminoacylation#GO:0043039;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;amino acid metabolic process#GO:0006520;gene expression#GO:0010467 aminoacyl-tRNA synthetase#PC00047 HUMAN|HGNC=24058|UniProtKB=Q8N6Y0 Q8N6Y0 USHBP1 PTHR23347:SF5 COLORECTAL MUTANT CANCER PROTEIN MCC PROTEIN -RELATED HARMONIN-BINDING PROTEIN USHBP1 HUMAN|HGNC=30079|UniProtKB=Q7Z410 Q7Z410 TMPRSS9 PTHR24253:SF81 TRANSMEMBRANE PROTEASE SERINE TRANSMEMBRANE PROTEASE SERINE 9 catalytic activity#GO:0003824;serine-type peptidase activity#GO:0008236;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;serine hydrolase activity#GO:0017171 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;proteolysis#GO:0006508;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;plasminogen activation#GO:0031639;protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;zymogen activation#GO:0031638 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 serine protease#PC00203;protease#PC00190;protein modifying enzyme#PC00260 HUMAN|HGNC=2362|UniProtKB=P46108 P46108 CRK PTHR19969:SF8 SH2-SH3 ADAPTOR PROTEIN-RELATED ADAPTER MOLECULE CRK protein binding#GO:0005515;signaling adaptor activity#GO:0035591;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;protein-macromolecule adaptor activity#GO:0030674;binding#GO:0005488;protein tyrosine kinase binding#GO:1990782;kinase binding#GO:0019900;signaling receptor binding#GO:0005102;receptor tyrosine kinase binding#GO:0030971;molecular adaptor activity#GO:0060090 cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell migration#GO:0016477;cell motility#GO:0048870;signaling#GO:0023052;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 scaffold/adaptor protein#PC00226 CCKR signaling map#P06959>CRK#P07125;Integrin signalling pathway#P00034>Crk#P00933;Angiogenesis#P00005>Crk#P00207 HUMAN|HGNC=30547|UniProtKB=Q96K17 Q96K17 BTF3L4 PTHR10351:SF29 TRANSCRIPTION FACTOR BTF3 FAMILY MEMBER TRANSCRIPTION FACTOR BTF3 HOMOLOG 4 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 DNA-binding transcription factor#PC00218 HUMAN|HGNC=9719|UniProtKB=P50542 P50542 PEX5 PTHR10130:SF2 PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR PEX5 PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR signal sequence receptor activity#GO:0005048;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 protein localization to organelle#GO:0033365;protein import into peroxisome matrix#GO:0016558;cellular component organization#GO:0016043;localization#GO:0051179;cellular localization#GO:0051641;transmembrane transport#GO:0055085;peroxisomal transport#GO:0043574;protein transport#GO:0015031;peroxisome organization#GO:0007031;organelle organization#GO:0006996;macromolecule localization#GO:0033036;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;establishment of protein localization to organelle#GO:0072594;cellular component organization or biogenesis#GO:0071840;intracellular protein transmembrane transport#GO:0065002;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;protein transmembrane import into intracellular organelle#GO:0044743;protein transmembrane transport#GO:0071806;transport#GO:0006810;intracellular protein transport#GO:0006886 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;peroxisomal membrane#GO:0005778;cellular anatomical structure#GO:0110165;microbody#GO:0042579;cytosol#GO:0005829;peroxisome#GO:0005777;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;intracellular organelle#GO:0043229 membrane traffic protein#PC00150;membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=196|UniProtKB=Q9Y3Q7 Q9Y3Q7 ADAM18 PTHR11905:SF158 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 18 hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metalloendopeptidase activity#GO:0004222;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 single fertilization#GO:0007338;sex differentiation#GO:0007548;cellular process#GO:0009987;male gonad development#GO:0008584;multicellular organismal process#GO:0032501;gonad development#GO:0008406;sperm-egg recognition#GO:0035036;development of primary male sexual characteristics#GO:0046546;metabolic process#GO:0008152;male sex differentiation#GO:0046661;development of primary sexual characteristics#GO:0045137;developmental process#GO:0032502;animal organ development#GO:0048513;multicellular organism development#GO:0007275;macromolecule metabolic process#GO:0043170;cell-cell recognition#GO:0009988;developmental process involved in reproduction#GO:0003006;primary metabolic process#GO:0044238;reproductive structure development#GO:0048608;fertilization#GO:0009566;reproductive process#GO:0022414;animal gross anatomical part developmental process#GO:0160108;proteolysis#GO:0006508;cell recognition#GO:0008037;cell adhesion#GO:0007155;sexual reproduction#GO:0019953;protein metabolic process#GO:0019538;anatomical structure development#GO:0048856;binding of sperm to zona pellucida#GO:0007339;reproductive system development#GO:0061458;system development#GO:0048731 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 metalloprotease#PC00153;protease#PC00190 HUMAN|HGNC=8659|UniProtKB=O60245 O60245 PCDH7 PTHR24028:SF253 CADHERIN-87A PROTOCADHERIN-7 cell adhesion#GO:0007155;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;synapse#GO:0045202;glutamatergic synapse#GO:0098978;cell junction#GO:0030054;cell periphery#GO:0071944;membrane#GO:0016020 cadherin#PC00057;cell adhesion molecule#PC00069 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HUMAN|HGNC=5552|UniProtKB=A0A0C4DH29 A0A0C4DH29 IGHV1-3 PTHR23266:SF379 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 1-3 binding#GO:0005488;antigen binding#GO:0003823 response to stimulus#GO:0050896;adaptive immune response#GO:0002250;immune response#GO:0006955;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;immune system process#GO:0002376;immune effector process#GO:0002252 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=25088|UniProtKB=Q5FBB7 Q5FBB7 SGO1 PTHR21577:SF4 SHUGOSHIN SHUGOSHIN 1 meiotic cell cycle#GO:0051321;chromosome segregation#GO:0007059;meiotic nuclear division#GO:0140013;homologous chromosome segregation#GO:0045143;cellular component organization or biogenesis#GO:0071840;chromosome organization#GO:0051276;microtubule-based process#GO:0007017;meiotic chromosome segregation#GO:0045132;meiotic sister chromatid cohesion#GO:0051177;microtubule organizing center organization#GO:0031023;organelle organization#GO:0006996;cellular process#GO:0009987;mitotic sister chromatid cohesion#GO:0007064;cytoskeleton organization#GO:0007010;nuclear division#GO:0000280;meiosis I cell cycle process#GO:0061982;sexual reproduction#GO:0019953;organelle fission#GO:0048285;sister chromatid cohesion#GO:0007062;microtubule cytoskeleton organization#GO:0000226;meiosis I#GO:0007127;cellular component organization#GO:0016043;meiotic cell cycle process#GO:1903046;nuclear chromosome segregation#GO:0098813;cell cycle#GO:0007049;cell cycle process#GO:0022402;centrosome cycle#GO:0007098;reproductive process#GO:0022414 intracellular organelle#GO:0043229;chromosome, centromeric region#GO:0000775;condensed chromosome#GO:0000793;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;kinetochore#GO:0000776;chromosome#GO:0005694;condensed chromosome, centromeric region#GO:0000779;intracellular membraneless organelle#GO:0043232;cohesin complex#GO:0008278;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;supramolecular complex#GO:0099080 centromere DNA-binding protein#PC00071 HUMAN|HGNC=23045|UniProtKB=Q8NEN0 Q8NEN0 ARMC2 PTHR21356:SF2 ARMADILLO REPEAT CONTAINING 2 ARMADILLO REPEAT-CONTAINING PROTEIN 2 axoneme assembly#GO:0035082;multicellular organismal reproductive process#GO:0048609;anatomical structure development#GO:0048856;microtubule cytoskeleton organization#GO:0000226;sexual reproduction#GO:0019953;spermatid development#GO:0007286;microtubule bundle formation#GO:0001578;organelle assembly#GO:0070925;reproductive process#GO:0022414;cell motility#GO:0048870;microtubule-based movement#GO:0007018;germ cell development#GO:0007281;developmental process involved in reproduction#GO:0003006;sperm axoneme assembly#GO:0007288;cellular developmental process#GO:0048869;spermatogenesis#GO:0007283;developmental process#GO:0032502;plasma membrane bounded cell projection assembly#GO:0120031;flagellated sperm motility#GO:0030317;plasma membrane bounded cell projection organization#GO:0120036;male gamete generation#GO:0048232;cilium organization#GO:0044782;cilium-dependent cell motility#GO:0060285;sperm flagellum assembly#GO:0120316;cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;spermatid differentiation#GO:0048515;cell development#GO:0048468;cellular process involved in reproduction in multicellular organism#GO:0022412;cell differentiation#GO:0030154;cell projection organization#GO:0030030;gamete generation#GO:0007276;sperm motility#GO:0097722;cilium assembly#GO:0060271;cellular component organization#GO:0016043;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;motile cilium assembly#GO:0044458;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cilium movement involved in cell motility#GO:0060294 HUMAN|HGNC=12380|UniProtKB=Q99598 Q99598 TSNAX PTHR10741:SF5 TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X TRANSLIN-ASSOCIATED PROTEIN X catalytic activity, acting on RNA#GO:0140098;RNA endonuclease activity#GO:0004521;RNA nuclease activity#GO:0004540;endonuclease activity#GO:0004519;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;RNA binding#GO:0003723;nuclease activity#GO:0004518;nucleic acid binding#GO:0003676;binding#GO:0005488 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=31409|UniProtKB=Q2I0M4 Q2I0M4 LRRC26 PTHR46473:SF2 GH08155P LEUCINE-RICH REPEAT-CONTAINING PROTEIN 26 monoatomic cation channel activity#GO:0005261;molecular function regulator activity#GO:0098772;ion channel regulator activity#GO:0099106;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;channel regulator activity#GO:0016247;potassium channel activity#GO:0005267;transporter regulator activity#GO:0141108;transmembrane transporter binding#GO:0044325;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;transporter activity#GO:0005215;voltage-gated channel activity#GO:0022832;protein binding#GO:0005515;monoatomic cation transmembrane transporter activity#GO:0008324;molecular function activator activity#GO:0140677;voltage-gated monoatomic ion channel activity#GO:0005244;binding#GO:0005488;gated channel activity#GO:0022836;potassium channel regulator activity#GO:0015459;voltage-gated potassium channel activity#GO:0005249 transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane#GO:0016020;membrane protein complex#GO:0098796 HUMAN|HGNC=27465|UniProtKB=Q8NDX6 Q8NDX6 ZNF740 PTHR24404:SF51 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 740 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218 HUMAN|HGNC=15351|UniProtKB=Q8NH42 Q8NH42 OR4K13 PTHR48002:SF139 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 4K13 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=3444|UniProtKB=P50548 P50548 ERF PTHR11849:SF31 ETS ETS DOMAIN-CONTAINING TRANSCRIPTION FACTOR ERF transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 winged helix/forkhead transcription factor#PC00246;DNA-binding transcription factor#PC00218 PDGF signaling pathway#P00047>Ets#P01167 HUMAN|HGNC=20873|UniProtKB=Q8NDP4 Q8NDP4 ZNF439 PTHR24381:SF244 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 439-RELATED binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=2752|UniProtKB=O75925 O75925 PIAS1 PTHR10782:SF11 ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN E3 SUMO-PROTEIN LIGASE PIAS1 catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;molecular function regulator activity#GO:0098772;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;SUMO transferase activity#GO:0019789;SUMO ligase activity#GO:0061665;molecular function inhibitor activity#GO:0140678;ubiquitin-like protein ligase activity#GO:0061659 regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of receptor signaling pathway via STAT#GO:1904892;regulation of cell communication#GO:0010646;primary metabolic process#GO:0044238;protein modification process#GO:0036211;regulation of DNA-templated transcription#GO:0006355;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of response to stimulus#GO:0048585;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;post-translational protein modification#GO:0043687;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;regulation of receptor signaling pathway via JAK-STAT#GO:0046425;regulation of response to stimulus#GO:0048583;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;protein modification by small protein conjugation#GO:0032446;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of cell communication#GO:0010648;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of signaling#GO:0023057;protein modification by small protein conjugation or removal#GO:0070647;regulation of signaling#GO:0023051;negative regulation of signal transduction#GO:0009968;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;protein sumoylation#GO:0016925;metabolic process#GO:0008152;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253 intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;chromatin#GO:0000785;nucleus#GO:0005634;membraneless organelle#GO:0043228;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 ubiquitin-protein ligase#PC00234 JAK/STAT signaling pathway#P00038>PIAS#P01031;Interferon-gamma signaling pathway#P00035>PIAS#P00958 HUMAN|HGNC=6874|UniProtKB=P53778 P53778 MAPK12 PTHR24055:SF146 MITOGEN-ACTIVATED PROTEIN KINASE MITOGEN-ACTIVATED PROTEIN KINASE 12 catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674 biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 non-receptor serine/threonine protein kinase#PC00167 p53 pathway feedback loops 2#P04398>p38 MAPK#P04648;p38 MAPK pathway#P05918>p38gamma#P06015;Ras Pathway#P04393>p38#P04558;Oxidative stress response#P00046>p38#P01135;B cell activation#P00010>p38#P00384;Alzheimer disease-amyloid secretase pathway#P00003>MAPK#P00099;EGF receptor signaling pathway#P00018>p38#P00562;TGF-beta signaling pathway#P00052>P38#P01275;Parkinson disease#P00049>SAPK#P01219;FGF signaling pathway#P00021>p38#P00644;Interferon-gamma signaling pathway#P00035>Serine kinase#P00955;Gonadotropin-releasing hormone receptor pathway#P06664>p38#P06831 HUMAN|HGNC=6947|UniProtKB=P33991 P33991 MCM4 PTHR11630:SF66 DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER DNA REPLICATION LICENSING FACTOR MCM4 macromolecular conformation isomerase activity#GO:0120543;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;DNA helicase activity#GO:0003678;isomerase activity#GO:0016853;catalytic activity, acting on DNA#GO:0140097;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;single-stranded DNA binding#GO:0003697;nucleic acid binding#GO:0003676;binding#GO:0005488;ATP-dependent activity, acting on DNA#GO:0008094;DNA binding#GO:0003677 double-strand break repair via homologous recombination#GO:0000724;cellular response to stimulus#GO:0051716;DNA replication#GO:0006260;cell cycle process#GO:0022402;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cell cycle#GO:0007049;DNA strand elongation involved in DNA replication#GO:0006271;mitotic cell cycle#GO:0000278;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;recombinational repair#GO:0000725;DNA-templated DNA replication#GO:0006261;cellular process#GO:0009987;double-strand break repair via break-induced replication#GO:0000727;response to stress#GO:0006950;nucleobase-containing compound metabolic process#GO:0006139;DNA recombination#GO:0006310;DNA replication initiation#GO:0006270;DNA damage response#GO:0006974;DNA metabolic process#GO:0006259;mitotic DNA replication#GO:1902969;nuclear DNA replication#GO:0033260;DNA repair#GO:0006281;cell cycle DNA replication#GO:0044786;metabolic process#GO:0008152;double-strand break repair#GO:0006302;mitotic cell cycle process#GO:1903047;macromolecule metabolic process#GO:0043170 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;MCM complex#GO:0042555;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634 DNA metabolism protein#PC00009 HUMAN|HGNC=451|UniProtKB=Q9UHK6 Q9UHK6 AMACR PTHR48228:SF8 SUCCINYL-COA--D-CITRAMALATE COA-TRANSFERASE ALPHA-METHYLACYL-COA RACEMASE catalytic activity#GO:0003824;racemase and epimerase activity#GO:0016854;isomerase activity#GO:0016853 lipid metabolic process#GO:0006629;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;cellular process#GO:0009987;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;steroid metabolic process#GO:0008202;small molecule metabolic process#GO:0044281 mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 transferase#PC00220;metabolite interconversion enzyme#PC00262 Carnitine metabolism#P02733>Carnitine dehydratase#P02866;Coenzyme A linked carnitine metabolism#P02732>L-carnitine dehydratase#P02864 HUMAN|HGNC=7166|UniProtKB=P08253 P08253 MMP2 PTHR10201:SF29 MATRIX METALLOPROTEINASE 72 KDA TYPE IV COLLAGENASE metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 extracellular matrix organization#GO:0030198;external encapsulating structure organization#GO:0045229;extracellular structure organization#GO:0043062;response to stimulus#GO:0050896;catabolic process#GO:0009056;tissue remodeling#GO:0048771;response to decreased oxygen levels#GO:0036293;response to oxygen levels#GO:0070482;response to abiotic stimulus#GO:0009628;cellular component organization#GO:0016043;cellular component organization or biogenesis#GO:0071840;response to hypoxia#GO:0001666;metabolic process#GO:0008152;multicellular organismal process#GO:0032501;response to stress#GO:0006950;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 metalloprotease#PC00153 Alzheimer disease-presenilin pathway#P00004>Matrix metalloprotease#P00130 HUMAN|HGNC=19741|UniProtKB=Q9NXS3 Q9NXS3 KLHL28 PTHR24412:SF441 KELCH PROTEIN KELCH-LIKE PROTEIN 28 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;enzyme-substrate adaptor activity#GO:0140767;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238 transferase complex#GO:1990234;catalytic complex#GO:1902494;Cul3-RING ubiquitin ligase complex#GO:0031463;ubiquitin ligase complex#GO:0000151;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cullin-RING ubiquitin ligase complex#GO:0031461;cytoplasm#GO:0005737 scaffold/adaptor protein#PC00226 HUMAN|HGNC=6892|UniProtKB=Q9UPY8 Q9UPY8 MAPRE3 PTHR10623:SF10 MICROTUBULE-ASSOCIATED PROTEIN RP/EB FAMILY MEMBER MICROTUBULE-ASSOCIATED PROTEIN RP_EB FAMILY MEMBER 3 protein binding#GO:0005515;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;microtubule binding#GO:0008017 macromolecule localization#GO:0033036;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;spindle assembly#GO:0051225;cellular process#GO:0009987;protein localization to microtubule cytoskeleton#GO:0072698;cellular component assembly#GO:0022607;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;regulation of microtubule cytoskeleton organization#GO:0070507;chromosome segregation#GO:0007059;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;intracellular protein localization#GO:0008104;microtubule-based process#GO:0007017;regulation of microtubule polymerization or depolymerization#GO:0031110;cell cycle#GO:0007049;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;protein localization to cytoskeleton#GO:0044380;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;cell cycle process#GO:0022402;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;protein localization to organelle#GO:0033365;regulation of cellular process#GO:0050794;organelle assembly#GO:0070925;regulation of microtubule-based process#GO:0032886;localization#GO:0051179;microtubule cytoskeleton organization#GO:0000226 microtubule cytoskeleton#GO:0015630;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;spindle#GO:0005819;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;microtubule plus-end#GO:0035371;cytoplasmic microtubule#GO:0005881;microtubule end#GO:1990752;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;spindle midzone#GO:0051233;supramolecular fiber#GO:0099512 microtubule or microtubule-binding cytoskeletal protein#PC00157;non-motor microtubule binding protein#PC00166 HUMAN|HGNC=4696|UniProtKB=P08236 P08236 GUSB PTHR10066:SF69 BETA-GLUCURONIDASE BETA-GLUCURONIDASE carbohydrate binding#GO:0030246;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824;protein binding#GO:0005515;hydrolase activity#GO:0016787;binding#GO:0005488;signaling receptor binding#GO:0005102 aminoglycan metabolic process#GO:0006022;protein catabolic process#GO:0030163;glycosaminoglycan catabolic process#GO:0006027;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;glycosaminoglycan metabolic process#GO:0030203;catabolic process#GO:0009056;carbohydrate derivative catabolic process#GO:1901136;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;glycoprotein metabolic process#GO:0009100;macromolecule metabolic process#GO:0043170;aminoglycan catabolic process#GO:0006026;proteoglycan metabolic process#GO:0006029;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;chondroitin sulfate proteoglycan metabolic process#GO:0050654 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=18761|UniProtKB=Q7Z2H8 Q7Z2H8 SLC36A1 PTHR22950:SF188 AMINO ACID TRANSPORTER PROTON-COUPLED AMINO ACID TRANSPORTER 1 proton transmembrane transporter activity#GO:0015078;amino acid transmembrane transporter activity#GO:0015171;secondary active transmembrane transporter activity#GO:0015291;neutral L-amino acid transmembrane transporter activity#GO:0015175;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;solute:monoatomic cation symporter activity#GO:0015294;monoatomic ion transmembrane transporter activity#GO:0015075;L-amino acid transmembrane transporter activity#GO:0015179;active transmembrane transporter activity#GO:0022804;glycine transmembrane transporter activity#GO:0015187;solute:proton symporter activity#GO:0015295;symporter activity#GO:0015293;carboxylic acid transmembrane transporter activity#GO:0046943;monoatomic cation transmembrane transporter activity#GO:0008324 monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;nitrogen compound transport#GO:0071705;L-amino acid transport#GO:0015807;cellular process#GO:0009987;establishment of localization#GO:0051234;proton transmembrane transport#GO:1902600;transport#GO:0006810;carboxylic acid transport#GO:0046942;organic acid transport#GO:0015849;amino acid transport#GO:0006865;alanine transport#GO:0032328;carboxylic acid transmembrane transport#GO:1905039;amino acid transmembrane transport#GO:0003333;transmembrane transport#GO:0055085;neutral amino acid transport#GO:0015804;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;glycine transport#GO:0015816 membrane#GO:0016020;vacuole#GO:0005773;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;vacuolar membrane#GO:0005774 secondary carrier transporter#PC00258;amino acid transporter#PC00046 HUMAN|HGNC=14764|UniProtKB=Q8NGJ7 Q8NGJ7 OR51A2 PTHR26450:SF168 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 51A2-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=12614|UniProtKB=Q9Y5T5 Q9Y5T5 USP16 PTHR21646:SF12 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 16 catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;cysteine-type deubiquitinase activity#GO:0004843;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005 regulation of biological quality#GO:0065008;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;regulation of protein stability#GO:0031647;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090 cysteine protease#PC00081 HUMAN|HGNC=30698|UniProtKB=Q6PIZ9 Q6PIZ9 TRAT1 PTHR15951:SF2 T-CELL RECEPTOR-ASSOCIATED TRANSMEMBRANE ADAPTER 1 T-CELL RECEPTOR-ASSOCIATED TRANSMEMBRANE ADAPTER 1 negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;regulation of immune response#GO:0050776;positive regulation of signaling#GO:0023056;positive regulation of signal transduction#GO:0009967;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of macromolecule metabolic process#GO:0060255;regulation of cell communication#GO:0010646;negative regulation of metabolic process#GO:0009892;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;regulation of metabolic process#GO:0019222;positive regulation of immune system process#GO:0002684;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966 membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;signaling receptor complex#GO:0043235 defense/immunity protein#PC00090 HUMAN|HGNC=1776|UniProtKB=Q13319 Q13319 CDK5R2 PTHR23401:SF3 CYCLIN DEPENDANT KINASE-5 ACTIVATOR CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 2 enzyme binding#GO:0019899;protein kinase binding#GO:0019901;kinase binding#GO:0019900;binding#GO:0005488;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;protein binding#GO:0005515;cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538;protein serine/threonine kinase activator activity#GO:0043539;enzyme activator activity#GO:0008047;protein kinase regulator activity#GO:0019887;kinase regulator activity#GO:0019207;kinase activator activity#GO:0019209;protein kinase activator activity#GO:0030295;cyclin-dependent protein kinase regulator activity#GO:0019914;molecular function regulator activity#GO:0098772 multicellular organismal process#GO:0032501;brain development#GO:0007420;plasma membrane bounded cell projection organization#GO:0120036;axon guidance#GO:0007411;axon development#GO:0061564;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;neuron projection guidance#GO:0097485;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;anatomical structure development#GO:0048856;system development#GO:0048731;head development#GO:0060322;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;neuron projection development#GO:0031175;cellular process#GO:0009987;animal organ development#GO:0048513;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cell projection morphogenesis#GO:0048858;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;cell differentiation#GO:0030154;central nervous system development#GO:0007417;cell development#GO:0048468;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;axonogenesis#GO:0007409;neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699 neuron projection#GO:0043005;cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;distal axon#GO:0150034;cell projection#GO:0042995;growth cone#GO:0030426;axon#GO:0030424;intracellular anatomical structure#GO:0005622;site of polarized growth#GO:0030427 kinase modulator#PC00140;kinase activator#PC00138 HUMAN|HGNC=28185|UniProtKB=Q9BRQ5 Q9BRQ5 ORAI3 PTHR31501:SF6 CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL PROTEIN 1 PROTEIN ORAI-3 channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;passive transmembrane transporter activity#GO:0022803;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;monoatomic cation channel activity#GO:0005261;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873 metal ion transport#GO:0030001;calcium ion transport#GO:0006816;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;establishment of localization#GO:0051234;transport#GO:0006810 membrane#GO:0016020;cellular anatomical structure#GO:0110165 ion channel#PC00133 HUMAN|HGNC=4268|UniProtKB=P27352 P27352 CBLIF PTHR10559:SF15 TRANSCOBALAMIN-1/GASTRIC INTRINSIC FACTOR COBALAMIN BINDING INTRINSIC FACTOR tetrapyrrole binding#GO:0046906;heterocyclic compound binding#GO:1901363;binding#GO:0005488;small molecule binding#GO:0036094 transport#GO:0006810;nitrogen compound transport#GO:0071705;establishment of localization#GO:0051234;vitamin transport#GO:0051180;localization#GO:0051179 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=14982|UniProtKB=Q9BWT3 Q9BWT3 PAPOLG PTHR10682:SF6 POLY A POLYMERASE POLY(A) POLYMERASE GAMMA transferase activity, transferring phosphorus-containing groups#GO:0016772;adenylyltransferase activity#GO:0070566;catalytic activity#GO:0003824;transferase activity#GO:0016740;nucleotidyltransferase activity#GO:0016779 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 RNA metabolism protein#PC00031;mRNA polyadenylation factor#PC00146 HUMAN|HGNC=23786|UniProtKB=Q8TBX8 Q8TBX8 PIP4K2C PTHR23086:SF35 PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE TYPE-2 GAMMA phosphatidylinositol kinase activity#GO:0052742;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;phosphotransferase activity, alcohol group as acceptor#GO:0016773;lipid kinase activity#GO:0001727 phospholipid metabolic process#GO:0006644;glycerolipid metabolic process#GO:0046486;phospholipid biosynthetic process#GO:0008654;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;organophosphate biosynthetic process#GO:0090407;phosphatidylinositol phosphate biosynthetic process#GO:0046854;biosynthetic process#GO:0009058;glycerophospholipid metabolic process#GO:0006650;lipid biosynthetic process#GO:0008610;glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;glycerophospholipid biosynthetic process#GO:0046474;lipid metabolic process#GO:0006629;metabolic process#GO:0008152 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 kinase#PC00137;transferase#PC00220 HUMAN|Ensembl=ENSG00000288261.1|UniProtKB=A0AAG2TTM8 A0AAG2TTM8 PTHR12138:SF167 PRIMATE-EXPANDED PROTEIN FAMILY SECRETED PROTEIN HUMAN|HGNC=303|UniProtKB=Q8IUX7 Q8IUX7 AEBP1 PTHR11532:SF48 PROTEASE M14 CARBOXYPEPTIDASE ADIPOCYTE ENHANCER-BINDING PROTEIN 1 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;carboxypeptidase activity#GO:0004180;DNA binding#GO:0003677;hydrolase activity#GO:0016787;metallocarboxypeptidase activity#GO:0004181;metallopeptidase activity#GO:0008237;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;catalytic activity, acting on a protein#GO:0140096;sequence-specific double-stranded DNA binding#GO:1990837;catalytic activity#GO:0003824;exopeptidase activity#GO:0008238;DNA-binding transcription repressor activity#GO:0001217;transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;peptidase activity#GO:0008233;sequence-specific DNA binding#GO:0043565;metalloexopeptidase activity#GO:0008235 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467;regulation of nucleobase-containing compound metabolic process#GO:0019219;protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;primary metabolic process#GO:0044238;regulation of RNA metabolic process#GO:0051252;peptide metabolic process#GO:0006518;regulation of DNA-templated transcription#GO:0006355;protein metabolic process#GO:0019538;proteolysis#GO:0006508 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease#PC00190 HUMAN|Ensembl=ENSG00000276017.1|UniProtKB=A0AAG2SYH1 A0AAG2SYH1 PTHR15566:SF6 POM121-LIKE POM121-LIKE PROTEIN 1-RELATED HUMAN|HGNC=2551|UniProtKB=Q13616 Q13616 CUL1 PTHR11932:SF168 CULLIN CULLIN-1 binding#GO:0005488;ubiquitin-like protein ligase binding#GO:0044389;enzyme binding#GO:0019899;protein complex scaffold activity#GO:0140378;protein binding#GO:0005515;ubiquitin protein ligase binding#GO:0031625;structural molecule activity#GO:0005198 cellular process#GO:0009987;proteasomal protein catabolic process#GO:0010498;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;protein modification process#GO:0036211;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;protein modification by small protein conjugation#GO:0032446;catabolic process#GO:0009056;protein modification by small protein conjugation or removal#GO:0070647;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412 organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;ubiquitin ligase complex#GO:0000151;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;intracellular organelle#GO:0043229;catalytic complex#GO:1902494 ubiquitin-protein ligase#PC00234 Parkinson disease#P00049>Cul-1#P01239 HUMAN|HGNC=25386|UniProtKB=Q6L8Q7 Q6L8Q7 PDE12 PTHR12121:SF37 CARBON CATABOLITE REPRESSOR PROTEIN 4 2',5'-PHOSPHODIESTERASE 12 3'-5' exonuclease activity#GO:0008408;catalytic activity, acting on RNA#GO:0140098;RNA nuclease activity#GO:0004540;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;nuclease activity#GO:0004518;exonuclease activity#GO:0004527;3'-5'-RNA exonuclease activity#GO:0000175 positive regulation of mRNA catabolic process#GO:0061014;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;nuclear-transcribed mRNA poly(A) tail shortening#GO:0000289;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;regulation of RNA stability#GO:0043487;regulation of RNA metabolic process#GO:0051252;nucleic acid catabolic process#GO:0141188;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;nucleobase-containing compound catabolic process#GO:0034655;regulation of primary metabolic process#GO:0080090;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;nuclear-transcribed mRNA catabolic process#GO:0000956;positive regulation of catabolic process#GO:0009896;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;macromolecule metabolic process#GO:0043170;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;regulation of mRNA stability#GO:0043488;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;RNA catabolic process#GO:0006401;regulation of biological quality#GO:0065008;RNA metabolic process#GO:0016070;positive regulation of metabolic process#GO:0009893;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;RNA destabilization#GO:0050779;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;positive regulation of macromolecule metabolic process#GO:0010604;mRNA destabilization#GO:0061157;macromolecule catabolic process#GO:0009057;positive regulation of mRNA metabolic process#GO:1903313;metabolic process#GO:0008152;regulation of mRNA metabolic process#GO:1903311 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 mRNA polyadenylation factor#PC00146 HUMAN|HGNC=4012|UniProtKB=P19526 P19526 FUT1 PTHR11927:SF4 GALACTOSIDE 2-L-FUCOSYLTRANSFERASE GALACTOSIDE ALPHA-(1,2)-FUCOSYLTRANSFERASE 1 hexosyltransferase activity#GO:0016758;fucosyltransferase activity#GO:0008417;transferase activity#GO:0016740;catalytic activity#GO:0003824;glycosyltransferase activity#GO:0016757 biosynthetic process#GO:0009058;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;protein O-linked glycosylation#GO:0006493;macromolecule biosynthetic process#GO:0009059;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 glycosyltransferase#PC00111 HUMAN|HGNC=28716|UniProtKB=Q8IYJ2 Q8IYJ2 C10orf67 PTHR22382:SF7 RIKEN CDNA 4921504E06 GENE RIKEN CDNA 4921504E06 GENE HUMAN|HGNC=7199|UniProtKB=P00540 P00540 MOS PTHR23257:SF706 SERINE-THREONINE PROTEIN KINASE PROTO-ONCOGENE SERINE_THREONINE-PROTEIN KINASE MOS phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;protein kinase activity#GO:0004672;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 positive regulation of cellular process#GO:0048522;positive regulation of response to stimulus#GO:0048584;regulation of reproductive process#GO:2000241;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of chromosome organization#GO:0033044;negative regulation of cellular process#GO:0048523;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;negative regulation of cell cycle process#GO:0010948;positive regulation of MAPK cascade#GO:0043410;negative regulation of chromosome separation#GO:1905819;regulation of cell cycle phase transition#GO:1901987;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;cell communication#GO:0007154;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of chromosome separation#GO:1905818;regulation of cell cycle process#GO:0010564;negative regulation of chromosome segregation#GO:0051985;negative regulation of metaphase/anaphase transition of cell cycle#GO:1902100;regulation of MAPK cascade#GO:0043408;regulation of chromosome segregation#GO:0051983;negative regulation of cell cycle#GO:0045786;negative regulation of biological process#GO:0048519;negative regulation of cell cycle phase transition#GO:1901988;regulation of meiotic cell cycle#GO:0051445;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;signaling#GO:0023052;regulation of cell cycle#GO:0051726;regulation of sister chromatid segregation#GO:0033045;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|Ensembl=ENSG00000275428.2|UniProtKB=A0AAG2SWI5 A0AAG2SWI5 PTHR11412:SF174 MACROGLOBULIN / COMPLEMENT OVOSTATIN HOMOLOG 1-RELATED enzyme inhibitor activity#GO:0004857;molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866;peptidase regulator activity#GO:0061134;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234 response to stimulus#GO:0050896;defense response#GO:0006952;response to stress#GO:0006950;inflammatory response#GO:0006954 extracellular region#GO:0005576;extracellular protein-containing complex#GO:0140392;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 protease inhibitor#PC00191 HUMAN|HGNC=14184|UniProtKB=Q9H9P5 Q9H9P5 UNKL PTHR14493:SF37 UNKEMPT FAMILY MEMBER E3 UBIQUITIN-PROTEIN LIGASE UNKL-RELATED HUMAN|HGNC=475|UniProtKB=P0DTE7 P0DTE7 AMY1B PTHR43447:SF50 ALPHA-AMYLASE ALPHA-AMYLASE 1A-RELATED cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 amylase#PC00048 HUMAN|HGNC=33710|UniProtKB=Q6NVV7 Q6NVV7 CDPF1 PTHR31849:SF1 CYSTEINE-RICH PDF MOTIF DOMAIN-CONTAINING PROTEIN 1 CYSTEINE-RICH DPF MOTIF DOMAIN-CONTAINING PROTEIN 1 HUMAN|HGNC=7115|UniProtKB=Q13434 Q13434 MKRN4P PTHR11224:SF53 MAKORIN-RELATED E3 UBIQUITIN-PROTEIN LIGASE MAKORIN-4-RELATED ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;protein modification process#GO:0036211;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=14448|UniProtKB=Q7RTX1 Q7RTX1 TAS1R1 PTHR24061:SF3 CALCIUM-SENSING RECEPTOR-RELATED TASTE RECEPTOR TYPE 1 MEMBER 1 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089 system process#GO:0003008;multicellular organismal process#GO:0032501;sensory perception#GO:0007600;nervous system process#GO:0050877;sensory perception of taste#GO:0050909;sensory perception of chemical stimulus#GO:0007606 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=18082|UniProtKB=Q9Y5S1 Q9Y5S1 TRPV2 PTHR10582:SF5 TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 2 channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;passive transmembrane transporter activity#GO:0022803;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873 transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;calcium ion transmembrane transport#GO:0070588;calcium ion import#GO:0070509;import across plasma membrane#GO:0098739;inorganic ion import across plasma membrane#GO:0099587;metal ion transport#GO:0030001;transport#GO:0006810;import into cell#GO:0098657;establishment of localization#GO:0051234;calcium ion transmembrane import into cytosol#GO:0097553;inorganic cation import across plasma membrane#GO:0098659;calcium ion transport#GO:0006816;cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 ion channel#PC00133;transporter#PC00227 HUMAN|HGNC=1460|UniProtKB=Q9UQM7 Q9UQM7 CAMK2A PTHR24347:SF384 SERINE/THREONINE-PROTEIN KINASE CALCIUM_CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT ALPHA catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;calmodulin binding#GO:0005516;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein kinase activity#GO:0004672;protein binding#GO:0005515;phosphotransferase activity, alcohol group as acceptor#GO:0016773;calcium/calmodulin-dependent protein kinase activity#GO:0004683;protein serine/threonine kinase activity#GO:0004674;binding#GO:0005488 regulation of biological process#GO:0050789;regulation of protein localization to membrane#GO:1905475;regulation of cellular process#GO:0050794;regulation of trans-synaptic signaling#GO:0099177;biological regulation#GO:0065007;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;regulation of synaptic plasticity#GO:0048167;regulation of signaling#GO:0023051;regulation of neuronal synaptic plasticity#GO:0048168;regulation of localization#GO:0032879;regulation of protein localization#GO:0032880;regulation of biological quality#GO:0065008 neuron projection#GO:0043005;postsynapse#GO:0098794;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;synapse#GO:0045202;neuron to neuron synapse#GO:0098984;asymmetric synapse#GO:0032279;postsynaptic specialization#GO:0099572;organelle#GO:0043226;postsynaptic density#GO:0014069;axon#GO:0030424;intracellular anatomical structure#GO:0005622;cell junction#GO:0030054 non-receptor serine/threonine protein kinase#PC00167 Ionotropic glutamate receptor pathway#P00037>CaMKII#P01023;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CaMK#P00847 HUMAN|HGNC=23589|UniProtKB=Q96F45 Q96F45 ZNF503 PTHR12522:SF3 ZINC-FINGER PROTEIN NOLZ1-RELATED ZINC FINGER PROTEIN 503 negative regulation of metabolic process#GO:0009892;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=18883|UniProtKB=P59536 P59536 TAS2R41 PTHR11394:SF73 TASTE RECEPTOR TYPE 2 TASTE RECEPTOR TYPE 2 MEMBER 41 taste receptor activity#GO:0008527;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;bitter taste receptor activity#GO:0033038;transmembrane signaling receptor activity#GO:0004888 nervous system process#GO:0050877;detection of chemical stimulus involved in sensory perception of taste#GO:0050912;sensory perception#GO:0007600;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of taste#GO:0050909;system process#GO:0003008;detection of chemical stimulus involved in sensory perception of bitter taste#GO:0001580;detection of chemical stimulus#GO:0009593;sensory perception of bitter taste#GO:0050913;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;multicellular organismal process#GO:0032501;response to chemical#GO:0042221;response to stimulus#GO:0050896 membrane#GO:0016020;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=10524|UniProtKB=Q9NSC2 Q9NSC2 SALL1 PTHR23233:SF51 SAL-LIKE PROTEIN SAL-LIKE PROTEIN 1 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HUMAN|HGNC=24261|UniProtKB=Q9Y3D0 Q9Y3D0 CIAO2B PTHR12377:SF0 CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B-RELATED CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HUMAN|HGNC=33709|UniProtKB=Q537H7 Q537H7 SPATA45 PTHR35822:SF1 SPERMATOGENESIS-ASSOCIATED PROTEIN 45 SPERMATOGENESIS-ASSOCIATED PROTEIN 45 HUMAN|HGNC=3265|UniProtKB=P05198 P05198 EIF2S1 PTHR10602:SF0 EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1 EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1 translation factor activity#GO:0180051;binding#GO:0005488;protein-containing complex binding#GO:0044877;translation initiation factor activity#GO:0003743;ribosome binding#GO:0043022;ribonucleoprotein complex binding#GO:0043021 protein biosynthetic process#GO:0160307;gene expression#GO:0010467;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;translational initiation#GO:0006413;translation#GO:0006412 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 translation factor#PC00223;translation initiation factor#PC00224 Apoptosis signaling pathway#P00006>ELF2alpha#P00307 HUMAN|HGNC=13135|UniProtKB=Q6ZN08 Q6ZN08 ZNF66 PTHR24384:SF214 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED ZINC FINGER PROTEIN 66 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA-binding transcription factor#PC00218 HUMAN|HGNC=28078|UniProtKB=A1A4V9 A1A4V9 CFAP119 PTHR28457:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 189 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 119 HUMAN|HGNC=6241|UniProtKB=Q9UJ90 Q9UJ90 KCNE5 PTHR15282:SF7 POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY E MEMBER 1, 3 POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY E REGULATORY BETA SUBUNIT 5 potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;channel regulator activity#GO:0016247;transporter regulator activity#GO:0141108;potassium channel activity#GO:0005267;transmembrane transporter binding#GO:0044325;monoatomic cation channel activity#GO:0005261;molecular function regulator activity#GO:0098772;passive transmembrane transporter activity#GO:0022803;ion channel regulator activity#GO:0099106;transmembrane transporter activity#GO:0022857;voltage-gated channel activity#GO:0022832;protein binding#GO:0005515;monoatomic cation transmembrane transporter activity#GO:0008324;binding#GO:0005488;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;potassium channel regulator activity#GO:0015459;voltage-gated potassium channel activity#GO:0005249;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;transporter activity#GO:0005215 monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;transmembrane transport#GO:0055085;action potential#GO:0001508;regulation of biological process#GO:0050789;muscle system process#GO:0003012;heart process#GO:0003015;export from cell#GO:0140352;regulation of membrane potential#GO:0042391;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;regulation of multicellular organismal process#GO:0051239;cardiac muscle cell action potential involved in contraction#GO:0086002;cardiac muscle contraction#GO:0060048;actin filament-based process#GO:0030029;circulatory system process#GO:0003013;localization#GO:0051179;monoatomic cation transport#GO:0006812;metal ion transport#GO:0030001;striated muscle contraction#GO:0006941;regulation of heart contraction#GO:0008016;actin-mediated cell contraction#GO:0070252;muscle contraction#GO:0006936;transport#GO:0006810;regulation of system process#GO:0044057;system process#GO:0003008;heart contraction#GO:0060047;establishment of localization#GO:0051234;cardiac muscle cell contraction#GO:0086003;actin filament-based movement#GO:0030048;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813;blood circulation#GO:0008015;multicellular organismal process#GO:0032501 cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703 voltage-gated ion channel#PC00241 HUMAN|HGNC=12313|UniProtKB=Q15652 Q15652 JMJD1C PTHR12549:SF6 JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROTEIN JUMONJI DOMAIN-CONTAINING PROTEIN 1C histone modifying activity#GO:0140993;DNA binding#GO:0003677;transcription regulator activity#GO:0140110;chromatin binding#GO:0003682;binding#GO:0005488;nucleic acid binding#GO:0003676;demethylase activity#GO:0032451;catalytic activity, acting on a protein#GO:0140096;protein demethylase activity#GO:0140457;chromatin DNA binding#GO:0031490;histone demethylase activity#GO:0032452;catalytic activity#GO:0003824;transcription coregulator activity#GO:0003712 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165;chromatin#GO:0000785;chromosome#GO:0005694 histone modifying enzyme#PC00261 HUMAN|HGNC=15460|UniProtKB=Q8IZS8 Q8IZS8 CACNA2D3 PTHR10166:SF25 VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2_DELTA-3 transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;voltage-gated channel activity#GO:0022832;calcium channel activity#GO:0005262;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261;channel activity#GO:0015267;voltage-gated calcium channel activity#GO:0005245 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;plasma membrane#GO:0005886;voltage-gated calcium channel complex#GO:0005891;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;calcium channel complex#GO:0034704;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cation channel complex#GO:0034703 transporter#PC00227;voltage-gated ion channel#PC00241 HUMAN|HGNC=11513|UniProtKB=O00445 O00445 SYT5 PTHR10024:SF282 SYNAPTOTAGMIN SYNAPTOTAGMIN-5 SNARE binding#GO:0000149;phospholipid binding#GO:0005543;binding#GO:0005488;lipid binding#GO:0008289;molecular function regulator activity#GO:0098772;molecular sensor activity#GO:0140299;protein binding#GO:0005515 anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;signal release from synapse#GO:0099643;chemical synaptic transmission#GO:0007268;cell communication#GO:0007154;regulation of secretion#GO:0051046;localization#GO:0051179;secretion#GO:0046903;regulation of exocytosis#GO:0017157;signal release#GO:0023061;trans-synaptic signaling#GO:0099537;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;neurotransmitter secretion#GO:0007269;positive regulation of cellular process#GO:0048522;establishment of localization#GO:0051234;transport#GO:0006810;synaptic vesicle cycle#GO:0099504;regulation of cellular component organization#GO:0051128;regulation of neurotransmitter secretion#GO:0046928;signaling#GO:0023052;export from cell#GO:0140352;regulation of synaptic vesicle exocytosis#GO:2000300;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;regulation of organelle organization#GO:0033043;cellular localization#GO:0051641;positive regulation of organelle organization#GO:0010638;secretion by cell#GO:0032940;regulation of secretion by cell#GO:1903530;regulation of neurotransmitter transport#GO:0051588;positive regulation of cellular component organization#GO:0051130;regulation of signaling#GO:0023051;regulation of trans-synaptic signaling#GO:0099177;vesicle-mediated transport#GO:0016192;neurotransmitter transport#GO:0006836;synaptic signaling#GO:0099536;positive regulation of biological process#GO:0048518;establishment of localization in cell#GO:0051649;synaptic vesicle exocytosis#GO:0016079;positive regulation of transport#GO:0051050;cellular process#GO:0009987;vesicle-mediated transport in synapse#GO:0099003;regulation of transport#GO:0051049;regulation of localization#GO:0032879;exocytosis#GO:0006887;positive regulation of vesicle fusion#GO:0031340;regulated exocytosis#GO:0045055 axon#GO:0030424;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;synaptic vesicle#GO:0008021;vesicle#GO:0031982;synaptic vesicle membrane#GO:0030672;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;organelle membrane#GO:0031090;cell periphery#GO:0071944;membrane#GO:0016020;vesicle membrane#GO:0012506;plasma membrane#GO:0005886;transport vesicle membrane#GO:0030658;endomembrane system#GO:0012505;transport vesicle#GO:0030133;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;intracellular vesicle#GO:0097708;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;bounding membrane of organelle#GO:0098588;cell junction#GO:0030054;neuron projection#GO:0043005;presynapse#GO:0098793;secretory vesicle#GO:0099503;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659 membrane trafficking regulatory protein#PC00151 Synaptic vesicle trafficking#P05734>Synaptotagmin#P05769 HUMAN|HGNC=692|UniProtKB=P40616 P40616 ARL1 PTHR11711:SF41 ADP RIBOSYLATION FACTOR-RELATED ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 1 GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;small molecule binding#GO:0036094;binding#GO:0005488;anion binding#GO:0043168;ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265;guanyl nucleotide binding#GO:0019001;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;nucleotide binding#GO:0000166;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553 vesicle-mediated transport#GO:0016192;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;protein transport#GO:0015031;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 G-protein#PC00020 Huntington disease#P00029>ARF#P00786;Integrin signalling pathway#P00034>Arf1#P00923 HUMAN|HGNC=6069|UniProtKB=O95050 O95050 INMT PTHR10867:SF33 NNMT/PNMT/TEMT FAMILY MEMBER INDOLETHYLAMINE N-METHYLTRANSFERASE catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741;methyltransferase activity#GO:0008168;N-methyltransferase activity#GO:0008170 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 methyltransferase#PC00155;transferase#PC00220 Adrenaline and noradrenaline biosynthesis#P00001>PNMT#P00061;Nicotine degradation#P05914>INMT#P05981 HUMAN|HGNC=32071|UniProtKB=Q5SZI1 Q5SZI1 LDLRAD2 PTHR24652:SF67 LOW-DENSITY LIPOPROTEIN RECEPTOR CLASS A DOMAIN-CONTAINING PROTEIN 2 LOW-DENSITY LIPOPROTEIN RECEPTOR CLASS A DOMAIN-CONTAINING PROTEIN 2 HUMAN|HGNC=6633|UniProtKB=Q9NZU5 Q9NZU5 LMCD1 PTHR24211:SF0 LIM DOMAIN-CONTAINING PROTEIN LIM AND CYSTEINE-RICH DOMAINS PROTEIN 1 transcription regulator activity#GO:0140110;transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712 negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;positive regulation of biological process#GO:0048518;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of calcineurin-NFAT signaling cascade#GO:0070884;regulation of multicellular organismal process#GO:0051239;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;positive regulation of signaling#GO:0023056;negative regulation of DNA-templated transcription#GO:0045892;regulation of biological process#GO:0050789;regulation of muscle system process#GO:0090257;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;regulation of system process#GO:0044057;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of calcium-mediated signaling#GO:0050850;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of signal transduction#GO:0009967;regulation of calcium-mediated signaling#GO:0050848;regulation of cell communication#GO:0010646;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647 nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 scaffold/adaptor protein#PC00226 HUMAN|HGNC=15954|UniProtKB=Q96GM8 Q96GM8 TOE1 PTHR15092:SF37 POLY A -SPECIFIC RIBONUCLEASE/TARGET OF EGR1, MEMBER 1 TARGET OF EGR1 PROTEIN 1 hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on RNA#GO:0140098;3'-5' exonuclease activity#GO:0008408;RNA nuclease activity#GO:0004540;3'-5'-RNA exonuclease activity#GO:0000175;binding#GO:0005488;nucleic acid binding#GO:0003676;exonuclease activity#GO:0004527;nuclease activity#GO:0004518;snRNA binding#GO:0017069;RNA binding#GO:0003723;hydrolase activity#GO:0016787 nucleic acid biosynthetic process#GO:0141187;snRNA metabolic process#GO:0016073;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;snRNA 3'-end processing#GO:0034472;RNA biosynthetic process#GO:0032774;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;snRNA processing#GO:0016180;RNA 3'-end processing#GO:0031123;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle lumen#GO:0043233;membraneless organelle#GO:0043228;intracellular membraneless organelle#GO:0043232;nuclear body#GO:0016604;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974 mRNA polyadenylation factor#PC00146 HUMAN|HGNC=2884|UniProtKB=Q92813 Q92813 DIO2 PTHR11781:SF20 IODOTHYRONINE DEIODINASE TYPE II IODOTHYRONINE DEIODINASE oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 phenol-containing compound metabolic process#GO:0018958;cellular process#GO:0009987;regulation of hormone levels#GO:0010817;modified amino acid metabolic process#GO:0006575;biological regulation#GO:0065007;hormone metabolic process#GO:0042445;metabolic process#GO:0008152;regulation of biological quality#GO:0065008 metabolite interconversion enzyme#PC00262 HUMAN|HGNC=19060|UniProtKB=Q8TDV5 Q8TDV5 GPR119 PTHR22750:SF7 G-PROTEIN COUPLED RECEPTOR GLUCOSE-DEPENDENT INSULINOTROPIC RECEPTOR transmembrane signaling receptor activity#GO:0004888;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;cation binding#GO:0043169;lipid binding#GO:0008289;molecular transducer activity#GO:0060089;phospholipid binding#GO:0005543;signaling receptor activity#GO:0038023;phosphatidylcholine binding#GO:0031210;G protein-coupled receptor activity#GO:0004930 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021 HUMAN|HGNC=9452|UniProtKB=Q9UNN8 Q9UNN8 PROCR PTHR15349:SF0 ENDOTHELIAL PROTEIN C RECEPTOR ENDOTHELIAL PROTEIN C RECEPTOR regulation of coagulation#GO:0050818;negative regulation of coagulation#GO:0050819;biological regulation#GO:0065007;regulation of multicellular organismal process#GO:0051239;negative regulation of biological process#GO:0048519;negative regulation of multicellular organismal process#GO:0051241;regulation of biological process#GO:0050789 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protein-binding activity modulator#PC00095 Blood coagulation#P00011>EPCR#P00403 HUMAN|HGNC=23393|UniProtKB=Q86X55 Q86X55 CARM1 PTHR11006:SF51 PROTEIN ARGININE N-METHYLTRANSFERASE HISTONE-ARGININE METHYLTRANSFERASE CARM1 protein methyltransferase activity#GO:0008276;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;N-methyltransferase activity#GO:0008170;histone methyltransferase activity#GO:0042054;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;histone modifying activity#GO:0140993;histone H3 methyltransferase activity#GO:0140938 regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;chromatin remodeling#GO:0006338;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;chromatin organization#GO:0006325;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 protein modifying enzyme#PC00260 HUMAN|HGNC=16432|UniProtKB=O14977 O14977 AZIN1 PTHR11482:SF7 ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE ANTIZYME INHIBITOR 1 molecular function regulator activity#GO:0098772;catalytic activity#GO:0003824;enzyme activator activity#GO:0008047;carboxy-lyase activity#GO:0016831;carbon-carbon lyase activity#GO:0016830;enzyme regulator activity#GO:0030234;lyase activity#GO:0016829;molecular function activator activity#GO:0140677;ornithine decarboxylase activity#GO:0004586 regulation of protein catabolic process#GO:0042176;negative regulation of catabolic process#GO:0009895;regulation of transmembrane transport#GO:0034762;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;polyamine metabolic process#GO:0006595;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of protein metabolic process#GO:0051248;negative regulation of metabolic process#GO:0009892;negative regulation of cellular process#GO:0048523;metabolic process#GO:0008152;regulation of catabolic process#GO:0009894;regulation of localization#GO:0032879;regulation of transport#GO:0051049;amine metabolic process#GO:0009308;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of transport#GO:0051050;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;polyamine biosynthetic process#GO:0006596;negative regulation of protein catabolic process#GO:0042177;biosynthetic process#GO:0009058;biological regulation#GO:0065007;biogenic amine metabolic process#GO:0006576 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 decarboxylase#PC00089;metabolite interconversion enzyme#PC00262 Ornithine degradation#P02758>Ornithine decarboxylase#P03053 HUMAN|HGNC=28164|UniProtKB=Q96M27 Q96M27 PRRC1 PTHR23276:SF2 PROTEIN PRRC1 PROTEIN PRRC1 binding#GO:0005488;protein kinase A binding#GO:0051018;protein kinase A regulatory subunit binding#GO:0034237;protein binding#GO:0005515 anatomical structure homeostasis#GO:0060249;multicellular organismal process#GO:0032501;multicellular organismal-level homeostasis#GO:0048871;homeostatic process#GO:0042592;tissue homeostasis#GO:0001894;epithelial structure maintenance#GO:0010669 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=13503|UniProtKB=Q9HC78 Q9HC78 ZBTB20 PTHR24399:SF19 ZINC FINGER AND BTB DOMAIN-CONTAINING ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 20 transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription repressor activity#GO:0001217;sequence-specific DNA binding#GO:0043565 negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of metabolic process#GO:0009892;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;regulation of multicellular organismal process#GO:0051239;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of cytokine production#GO:0001817 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974 C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218 HUMAN|HGNC=10413|UniProtKB=P62851 P62851 RPS25 PTHR12850:SF18 40S RIBOSOMAL PROTEIN S25 SMALL RIBOSOMAL SUBUNIT PROTEIN ES25 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;cytosolic small ribosomal subunit#GO:0022627;intracellular organelle#GO:0043229;small ribosomal subunit#GO:0015935;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytosolic ribosome#GO:0022626;cytosol#GO:0005829;ribosome#GO:0005840 ribosomal protein#PC00202 HUMAN|HGNC=6463|UniProtKB=O43790 O43790 KRT86 PTHR45616:SF7 GATA-TYPE DOMAIN-CONTAINING PROTEIN KERATIN, TYPE II CUTICULAR HB6 structural molecule activity#GO:0005198 anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;intermediate filament-based process#GO:0045103;animal gross anatomical part developmental process#GO:0160108;keratinocyte differentiation#GO:0030216;intermediate filament organization#GO:0045109;cell differentiation#GO:0030154;intermediate filament cytoskeleton organization#GO:0045104;cellular component organization#GO:0016043;cellular component organization or biogenesis#GO:0071840;animal organ development#GO:0048513;cellular developmental process#GO:0048869;epidermis development#GO:0008544;developmental process#GO:0032502;epithelium development#GO:0060429;epithelial cell differentiation#GO:0030855;multicellular organismal process#GO:0032501;tissue development#GO:0009888;epidermal cell differentiation#GO:0009913;cytoskeleton organization#GO:0007010;skin development#GO:0043588;organelle organization#GO:0006996;cellular process#GO:0009987 polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;intermediate filament#GO:0005882;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;organelle#GO:0043226;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232 HUMAN|HGNC=11595|UniProtKB=O95935 O95935 TBX18 PTHR11267:SF20 T-BOX PROTEIN-RELATED T-BOX TRANSCRIPTION FACTOR TBX18 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 developmental process#GO:0032502;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;epithelium development#GO:0060429;multicellular organismal process#GO:0032501;regionalization#GO:0003002;tissue development#GO:0009888;pattern specification process#GO:0007389;embryo development ending in birth or egg hatching#GO:0009792;regulation of RNA metabolic process#GO:0051252;tissue morphogenesis#GO:0048729;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;cell fate specification#GO:0001708;anterior/posterior pattern specification#GO:0009952;anatomical structure formation involved in morphogenesis#GO:0048646;morphogenesis of an epithelium#GO:0002009;multicellular organism development#GO:0007275;embryonic morphogenesis#GO:0048598;cellular process#GO:0009987;embryo development#GO:0009790;animal gross anatomical part developmental process#GO:0160108;chordate embryonic development#GO:0043009;cell fate commitment#GO:0045165;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154 nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 Rel homology transcription factor#PC00252;immunoglobulin fold transcription factor#PC00251 HUMAN|HGNC=9457|UniProtKB=O94903 O94903 PLPBP PTHR10146:SF18 PROLINE SYNTHETASE CO-TRANSCRIBED BACTERIAL HOMOLOG PROTEIN PYRIDOXAL PHOSPHATE HOMEOSTASIS PROTEIN ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;anion binding#GO:0043168;heterocyclic compound binding#GO:1901363 metabolic process#GO:0008152;pyridine-containing compound metabolic process#GO:0072524;cellular process#GO:0009987;small molecule metabolic process#GO:0044281 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=10852|UniProtKB=P34897 P34897 SHMT2 PTHR11680:SF28 SERINE HYDROXYMETHYLTRANSFERASE SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;catalytic activity#GO:0003824;heterocyclic compound binding#GO:1901363;ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;binding#GO:0005488 amino acid metabolic process#GO:0006520;biosynthetic process#GO:0009058;proteinogenic amino acid metabolic process#GO:0170039;cellular process#GO:0009987;proteinogenic amino acid biosynthetic process#GO:0170038;small molecule biosynthetic process#GO:0044283;amino acid biosynthetic process#GO:0008652;metabolic process#GO:0008152;folic acid-containing compound metabolic process#GO:0006760;pteridine-containing compound metabolic process#GO:0042558;small molecule metabolic process#GO:0044281;carboxylic acid biosynthetic process#GO:0046394;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;modified amino acid metabolic process#GO:0006575;tetrahydrofolate metabolic process#GO:0046653;oxoacid metabolic process#GO:0043436 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739 metabolite interconversion enzyme#PC00262;methyltransferase#PC00155 Serine glycine biosynthesis#P02776>Glycine hydroxymethyltransferase#P03158 HUMAN|HGNC=20649|UniProtKB=Q8TAQ5 Q8TAQ5 ZNF420 PTHR24377:SF980 IP01015P-RELATED ZINC FINGER PROTEIN 420 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=29120|UniProtKB=O94889 O94889 KLHL18 PTHR24412:SF497 KELCH PROTEIN KELCH-LIKE PROTEIN 18 enzyme-substrate adaptor activity#GO:0140767;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 transferase complex#GO:1990234;catalytic complex#GO:1902494;Cul3-RING ubiquitin ligase complex#GO:0031463;ubiquitin ligase complex#GO:0000151;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cullin-RING ubiquitin ligase complex#GO:0031461;cytoplasm#GO:0005737 scaffold/adaptor protein#PC00226 HUMAN|HGNC=20959|UniProtKB=Q9UPN6 Q9UPN6 SCAF8 PTHR15921:SF7 PRE-MRNA CLEAVAGE COMPLEX II SR-RELATED AND CTD-ASSOCIATED FACTOR 8 RNA binding#GO:0003723;protein binding#GO:0005515;RNA polymerase II complex binding#GO:0000993;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488;enzyme binding#GO:0019899;RNA polymerase core enzyme binding#GO:0043175;RNA polymerase binding#GO:0070063 DNA-templated transcription termination#GO:0006353;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;termination of RNA polymerase II transcription#GO:0006369;nucleobase-containing compound biosynthetic process#GO:0034654;transcription by RNA polymerase II#GO:0006366;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070 nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;mRNA cleavage factor complex#GO:0005849;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HUMAN|HGNC=9920|UniProtKB=P50120 P50120 RBP2 PTHR11955:SF59 FATTY ACID BINDING PROTEIN RETINOL-BINDING PROTEIN 2 ion binding#GO:0043167;small molecule binding#GO:0036094;carboxylic acid binding#GO:0031406;binding#GO:0005488;anion binding#GO:0043168;organic acid binding#GO:0043177;fatty acid binding#GO:0005504;lipid binding#GO:0008289 lipid transport#GO:0006869;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;localization#GO:0051179;fatty acid transport#GO:0015908;monocarboxylic acid transport#GO:0015718;lipid localization#GO:0010876;organic acid transport#GO:0015849;transport#GO:0006810;carboxylic acid transport#GO:0046942 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cytosol#GO:0005829;nucleus#GO:0005634 transfer/carrier protein#PC00219 HUMAN|HGNC=4129|UniProtKB=Q86SF2 Q86SF2 GALNT7 PTHR11675:SF68 N-ACETYLGALACTOSAMINYLTRANSFERASE N-ACETYLGALACTOSAMINYLTRANSFERASE 7 acetylgalactosaminyltransferase activity#GO:0008376;glycosyltransferase activity#GO:0016757;catalytic activity, acting on a protein#GO:0140096;UDP-glycosyltransferase activity#GO:0008194;hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;catalytic activity#GO:0003824;polypeptide N-acetylgalactosaminyltransferase activity#GO:0004653 glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein O-linked glycosylation#GO:0006493;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 glycosyltransferase#PC00111;transferase#PC00220 HUMAN|HGNC=11719|UniProtKB=P42680 P42680 TEC PTHR24418:SF219 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE TEC transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;protein tyrosine kinase activity#GO:0004713;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;non-membrane spanning protein tyrosine kinase activity#GO:0004715;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 non-receptor tyrosine protein kinase#PC00168 HUMAN|HGNC=16790|UniProtKB=Q8IYK4 Q8IYK4 COLGALT2 PTHR10730:SF8 PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER PROCOLLAGEN GALACTOSYLTRANSFERASE 2 glycosyltransferase activity#GO:0016757;catalytic activity, acting on a protein#GO:0140096;UDP-glycosyltransferase activity#GO:0008194;galactosyltransferase activity#GO:0008378;catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758 protein modifying enzyme#PC00260 HUMAN|HGNC=3623|UniProtKB=O00602 O00602 FCN1 PTHR19143:SF377 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FICOLIN-1 external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HUMAN|HGNC=18748|UniProtKB=Q8WYK1 Q8WYK1 CNTNAP5 PTHR15036:SF46 PIKACHURIN-LIKE PROTEIN CONTACTIN-ASSOCIATED PROTEIN-LIKE 5 developmental process#GO:0032502;multicellular organism development#GO:0007275;signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;cell communication#GO:0007154;anatomical structure development#GO:0048856;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 plasma membrane#GO:0005886;cell junction#GO:0030054;cellular anatomical structure#GO:0110165;synapse#GO:0045202;cell periphery#GO:0071944;membrane#GO:0016020 cell adhesion molecule#PC00069 HUMAN|HGNC=3072|UniProtKB=Q16828 Q16828 DUSP6 PTHR10159:SF45 DUAL SPECIFICITY PROTEIN PHOSPHATASE DUAL SPECIFICITY PROTEIN PHOSPHATASE 6 hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725;protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721;catalytic activity#GO:0003824;protein tyrosine/serine/threonine phosphatase activity#GO:0008138;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096 negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;positive regulation of programmed cell death#GO:0043068;response to stimulus#GO:0050896;signaling#GO:0023052;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;regulation of multicellular organismal development#GO:2000026;regulation of biological process#GO:0050789;positive regulation of apoptotic process#GO:0043065;regulation of apoptotic process#GO:0042981;regulation of MAPK cascade#GO:0043408;negative regulation of ERK1 and ERK2 cascade#GO:0070373;regulation of ERK1 and ERK2 cascade#GO:0070372;regulation of multicellular organismal process#GO:0051239;negative regulation of signal transduction#GO:0009968;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cell communication#GO:0007154;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of developmental process#GO:0050793;negative regulation of MAPK cascade#GO:0043409;cellular response to stimulus#GO:0051716;regulation of growth#GO:0040008;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;negative regulation of response to stimulus#GO:0048585;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of cellular process#GO:0048522 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protein phosphatase#PC00195 Oxidative stress response#P00046>MKP5#P01131 HUMAN|HGNC=18808|UniProtKB=Q9Y6E2 Q9Y6E2 BZW2 PTHR14208:SF7 BASIC LEUCINE ZIPPER AND W2 DOMAIN-CONTAINING PROTEIN EIF5-MIMIC PROTEIN 1 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 basic leucine zipper transcription factor#PC00056 HUMAN|HGNC=18057|UniProtKB=Q63ZE4 Q63ZE4 SLC22A10 PTHR24064:SF278 SOLUTE CARRIER FAMILY 22 MEMBER SOLUTE CARRIER FAMILY 22 MEMBER 10 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;cellular process#GO:0009987;transport#GO:0006810 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 secondary carrier transporter#PC00258 HUMAN|HGNC=21392|UniProtKB=Q96DU3 Q96DU3 SLAMF6 PTHR12080:SF16 SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE SLAM FAMILY MEMBER 6 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 biological regulation#GO:0065007;lymphocyte activation#GO:0046649;multicellular organismal process#GO:0032501;immune response#GO:0006955;signal transduction#GO:0007165;cellular process#GO:0009987;cell communication#GO:0007154;cell activation#GO:0001775;immune system process#GO:0002376;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;leukocyte activation#GO:0045321;T cell activation#GO:0042110 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=15449|UniProtKB=Q9UHV8 Q9UHV8 LGALS13 PTHR11346:SF120 GALECTIN GALACTOSIDE-BINDING SOLUBLE LECTIN 13-RELATED binding#GO:0005488;carbohydrate binding#GO:0030246 extracellular matrix protein#PC00102 HUMAN|HGNC=15018|UniProtKB=Q8NHC8 Q8NHC8 OR2T6 PTHR26453:SF57 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2T6 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 response to stimulus#GO:0050896;response to chemical#GO:0042221;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;detection of chemical stimulus#GO:0009593;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;system process#GO:0003008;sensory perception#GO:0007600;nervous system process#GO:0050877;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=18734|UniProtKB=P42285 P42285 MTREX PTHR12131:SF7 ATP-DEPENDENT RNA AND DNA HELICASE EXOSOME RNA HELICASE MTR4 macromolecular conformation isomerase activity#GO:0120543;catalytic activity#GO:0003824;RNA helicase activity#GO:0003724;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on RNA#GO:0140098;isomerase activity#GO:0016853;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657 macromolecule catabolic process#GO:0009057;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;nucleobase-containing compound catabolic process#GO:0034655;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;nucleic acid catabolic process#GO:0141188;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;ribosome biogenesis#GO:0042254;RNA catabolic process#GO:0006401;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;catabolic process#GO:0009056;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;maturation of 5.8S rRNA#GO:0000460 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513 DNA metabolism protein#PC00009 HUMAN|HGNC=31271|UniProtKB=A6NHA9 A6NHA9 OR4C46 PTHR48002:SF182 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 4C46 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=21347|UniProtKB=Q7L2Z9 Q7L2Z9 CENPQ PTHR31345:SF3 CENTROMERE PROTEIN Q CENTROMERE PROTEIN Q nuclear chromosome segregation#GO:0098813;cell cycle#GO:0007049;cellular process#GO:0009987;cell cycle process#GO:0022402;chromosome localization#GO:0050000;organelle localization#GO:0051640;metaphase chromosome alignment#GO:0051310;chromosome segregation#GO:0007059;localization#GO:0051179 supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;condensed chromosome, centromeric region#GO:0000779;nucleus#GO:0005634;membraneless organelle#GO:0043228;chromosome, centromeric region#GO:0000775;condensed chromosome#GO:0000793;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;kinetochore#GO:0000776;membrane-bounded organelle#GO:0043227;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=4479|UniProtKB=Q99705 Q99705 MCHR1 PTHR24229:SF91 NEUROPEPTIDES RECEPTOR MELANIN-CONCENTRATING HORMONE RECEPTOR 1 molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;binding#GO:0005488;peptide binding#GO:0042277;neuropeptide binding#GO:0042923;transmembrane signaling receptor activity#GO:0004888 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;neuropeptide signaling pathway#GO:0007218;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 cell periphery#GO:0071944;neuron projection#GO:0043005;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021 HUMAN|HGNC=14552|UniProtKB=Q14164 Q14164 IKBKE PTHR22969:SF10 IKB KINASE INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT EPSILON protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;positive regulation of cytokine production#GO:0001819;regulation of macromolecule metabolic process#GO:0060255;regulation of response to biotic stimulus#GO:0002831;positive regulation of type I interferon production#GO:0032481;positive regulation of biosynthetic process#GO:0009891;regulation of defense response#GO:0031347;regulation of immune response#GO:0050776;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of cytokine production#GO:0001817;activation of innate immune response#GO:0002218;positive regulation of innate immune response#GO:0045089;positive regulation of cellular process#GO:0048522;regulation of biosynthetic process#GO:0009889;regulation of innate immune response#GO:0045088;regulation of gene expression#GO:0010468;positive regulation of response to biotic stimulus#GO:0002833;positive regulation of gene expression#GO:0010628;regulation of response to stress#GO:0080134;regulation of response to stimulus#GO:0048583;positive regulation of defense response#GO:0031349;positive regulation of immune response#GO:0050778;positive regulation of multicellular organismal process#GO:0051240;regulation of biological process#GO:0050789;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;immune system process#GO:0002376;regulation of response to external stimulus#GO:0032101;positive regulation of macromolecule metabolic process#GO:0010604;regulation of multicellular organismal process#GO:0051239;positive regulation of immune system process#GO:0002684;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;positive regulation of response to external stimulus#GO:0032103 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 Toll receptor signaling pathway#P00054>IKKepsilon#P01372;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>IKK#P00871 HUMAN|HGNC=24772|UniProtKB=Q8IX94 Q8IX94 CTAGE4 PTHR23158:SF57 MELANOMA INHIBITORY ACTIVITY-RELATED CTAGE FAMILY MEMBER 15-RELATED transport#GO:0006810;Golgi vesicle transport#GO:0048193;intracellular transport#GO:0046907;establishment of protein localization to extracellular region#GO:0035592;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;macromolecule localization#GO:0033036;vesicle-mediated transport#GO:0016192;protein transport#GO:0015031;secretion by cell#GO:0032940;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;secretion#GO:0046903;cellular localization#GO:0051641;protein secretion#GO:0009306;localization#GO:0051179;protein localization to extracellular region#GO:0071692;export from cell#GO:0140352 organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum exit site#GO:0070971;endoplasmic reticulum#GO:0005783;endomembrane system#GO:0012505;cytoplasm#GO:0005737;membrane#GO:0016020 membrane traffic protein#PC00150 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HUMAN|HGNC=29100|UniProtKB=Q5JTH9 Q5JTH9 RRP12 PTHR21576:SF2 UNCHARACTERIZED NODULIN-LIKE PROTEIN RRP12-LIKE PROTEIN nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974 HUMAN|HGNC=14517|UniProtKB=Q8N983 Q8N983 MRPL43 PTHR21396:SF2 39S RIBOSOMAL PROTEIN L43 LARGE RIBOSOMAL SUBUNIT PROTEIN ML43 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;mitochondrial gene expression#GO:0140053;metabolic process#GO:0008152;translation#GO:0006412;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;mitochondrial translation#GO:0032543;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 mitochondrial ribosome#GO:0005761;intracellular anatomical structure#GO:0005622;organellar ribosome#GO:0000313;membrane-bounded organelle#GO:0043227;large ribosomal subunit#GO:0015934;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;ribosome#GO:0005840;mitochondrion#GO:0005739;membraneless organelle#GO:0043228;mitochondrial large ribosomal subunit#GO:0005762;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974 ribosomal protein#PC00202 HUMAN|HGNC=11278|UniProtKB=O15270 O15270 SPTLC2 PTHR13693:SF79 CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE SERINE PALMITOYLTRANSFERASE 2 palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746 alcohol biosynthetic process#GO:0046165;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;small molecule metabolic process#GO:0044281;lipid biosynthetic process#GO:0008610;ceramide biosynthetic process#GO:0046513;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152;sphingolipid metabolic process#GO:0006665;sphingolipid biosynthetic process#GO:0030148;alcohol metabolic process#GO:0006066;sphingoid biosynthetic process#GO:0046520;ceramide metabolic process#GO:0006672 protein-containing complex#GO:0032991;transferase complex#GO:1990234;catalytic complex#GO:1902494 transaminase#PC00216 HUMAN|HGNC=15585|UniProtKB=Q9HCH5 Q9HCH5 SYTL2 PTHR45716:SF5 BITESIZE, ISOFORM I SYNAPTOTAGMIN-LIKE PROTEIN 2 protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488 cellular process#GO:0009987;export from cell#GO:0140352;vesicle-mediated transport#GO:0016192;transport#GO:0006810;secretion by cell#GO:0032940;exocytosis#GO:0006887;secretion#GO:0046903;establishment of localization#GO:0051234;localization#GO:0051179 intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;secretory vesicle#GO:0099503;membrane#GO:0016020;cell periphery#GO:0071944;transport vesicle#GO:0030133;endomembrane system#GO:0012505;plasma membrane#GO:0005886;cytoplasm#GO:0005737 membrane traffic protein#PC00150;membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=20363|UniProtKB=O15033 O15033 AREL1 PTHR11254:SF340 HECT DOMAIN UBIQUITIN-PROTEIN LIGASE APOPTOSIS-RESISTANT E3 UBIQUITIN PROTEIN LIGASE 1 acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 modification-dependent protein catabolic process#GO:0019941;regulation of biological process#GO:0050789;primary metabolic process#GO:0044238;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;cellular process#GO:0009987;negative regulation of programmed cell death#GO:0043069;biological regulation#GO:0065007;negative regulation of apoptotic process#GO:0043066;regulation of apoptotic process#GO:0042981;macromolecule catabolic process#GO:0009057;negative regulation of cellular process#GO:0048523;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=30052|UniProtKB=Q8TEM1 Q8TEM1 NUP210 PTHR23019:SF2 NUCLEAR PORE MEMBRANE GLYCOPROTEIN GP210-RELATED NUCLEAR PORE MEMBRANE GLYCOPROTEIN 210 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear pore#GO:0005643;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;organelle envelope#GO:0031967;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 transporter#PC00227 HUMAN|HGNC=11619|UniProtKB=Q15370 Q15370 ELOB PTHR13248:SF5 TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2 ELONGIN-B transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 nucleic acid catabolic process#GO:0141188;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;nucleobase-containing compound catabolic process#GO:0034655;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;ubiquitin-dependent protein catabolic process#GO:0006511;regulation of gene expression#GO:0010468;positive regulation of gene expression#GO:0010628;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;modification-dependent protein catabolic process#GO:0019941;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;post-transcriptional gene silencing#GO:0016441;protein metabolic process#GO:0019538;positive regulation of biosynthetic process#GO:0009891;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;negative regulation of macromolecule biosynthetic process#GO:0010558;proteasomal protein catabolic process#GO:0010498;positive regulation of macromolecule metabolic process#GO:0010604;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of gene silencing by regulatory ncRNA#GO:0060966;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;RNA catabolic process#GO:0006401;RNA metabolic process#GO:0016070;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893 nuclear protein-containing complex#GO:0140513;Cul3-RING ubiquitin ligase complex#GO:0031463;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;ubiquitin ligase complex#GO:0000151;Cul5-RING ubiquitin ligase complex#GO:0031466;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;Cul2-RING ubiquitin ligase complex#GO:0031462;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;transcription elongation factor complex#GO:0008023;cullin-RING ubiquitin ligase complex#GO:0031461;organelle lumen#GO:0043233 general transcription factor#PC00259 HUMAN|HGNC=4298|UniProtKB=P16278 P16278 GLB1 PTHR23421:SF172 BETA-GALACTOSIDASE RELATED BETA-GALACTOSIDASE hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798 catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;small molecule catabolic process#GO:0044282;carbohydrate metabolic process#GO:0005975;primary metabolic process#GO:0044238;hexose metabolic process#GO:0019318;cellular process#GO:0009987;carbohydrate catabolic process#GO:0016052;monosaccharide metabolic process#GO:0005996;metabolic process#GO:0008152 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;lytic vacuole#GO:0000323;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;vacuole#GO:0005773;cellular anatomical structure#GO:0110165;organelle#GO:0043226;lysosome#GO:0005764 hydrolase#PC00121;galactosidase#PC00104 HUMAN|HGNC=17983|UniProtKB=Q96LB1 Q96LB1 MRGPRX2 PTHR11334:SF70 MAS-RELATED G-PROTEIN COUPLED RECEPTOR MAS-RELATED G PROTEIN-COUPLED RECEPTOR MEMBER X2 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=3471|UniProtKB=P11474 P11474 ESRRA PTHR48092:SF15 KNIRPS-RELATED PROTEIN-RELATED STEROID HORMONE RECEPTOR ERR1 binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;molecular transducer activity#GO:0060089;DNA binding#GO:0003677;nuclear receptor activity#GO:0004879;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C4 zinc finger nuclear receptor#PC00169;zinc finger transcription factor#PC00244 Gonadotropin-releasing hormone receptor pathway#P06664>ER#P06851 HUMAN|HGNC=2025|UniProtKB=P51798 P51798 CLCN7 PTHR11689:SF169 CHLORIDE CHANNEL PROTEIN CLC FAMILY MEMBER H(+)_CL(-) EXCHANGE TRANSPORTER 7 proton transmembrane transporter activity#GO:0015078;antiporter activity#GO:0015297;chloride channel activity#GO:0005254;passive transmembrane transporter activity#GO:0022803;chloride transmembrane transporter activity#GO:0015108;secondary active transmembrane transporter activity#GO:0015291;monoatomic anion transmembrane transporter activity#GO:0008509;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;active transmembrane transporter activity#GO:0022804;monoatomic anion channel activity#GO:0005253;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267 cellular process#GO:0009987;monoatomic anion transport#GO:0006820;monoatomic ion transmembrane transport#GO:0034220;monoatomic anion transmembrane transport#GO:0098656;transport#GO:0006810;chloride transport#GO:0006821;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;chloride transmembrane transport#GO:1902476;localization#GO:0051179 transmembrane transporter complex#GO:1902495;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;lytic vacuole membrane#GO:0098852;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;lysosome#GO:0005764;vesicle#GO:0031982;vacuolar membrane#GO:0005774;transporter complex#GO:1990351;lytic vacuole#GO:0000323;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;late endosome#GO:0005770;monoatomic ion channel complex#GO:0034702;cytoplasm#GO:0005737;vacuole#GO:0005773;membrane#GO:0016020;lysosomal membrane#GO:0005765 ion channel#PC00133 HUMAN|HGNC=16223|UniProtKB=Q86VX2 Q86VX2 COMMD7 PTHR16231:SF2 COMM DOMAIN-CONTAINING PROTEIN 4-8 FAMILY MEMBER COMM DOMAIN-CONTAINING PROTEIN 7 protein complex scaffold activity#GO:0140378;structural molecule activity#GO:0005198 cell surface receptor signaling pathway#GO:0007166;response to chemical#GO:0042221;response to cytokine#GO:0034097;biological regulation#GO:0065007;response to tumor necrosis factor#GO:0034612;cellular process#GO:0009987;signal transduction#GO:0007165;tumor necrosis factor-mediated signaling pathway#GO:0033209;cell communication#GO:0007154;response to peptide#GO:1901652;cytokine-mediated signaling pathway#GO:0019221;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;cellular response to stimulus#GO:0051716;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789 protein-containing complex#GO:0032991 HUMAN|HGNC=17363|UniProtKB=Q8IY57 Q8IY57 YAF2 PTHR12920:SF2 RYBP AND YAF2-RELATED YY1-ASSOCIATED FACTOR 2 DNA binding#GO:0003677;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 transcription cofactor#PC00217 HUMAN|HGNC=656|UniProtKB=P49703 P49703 ARL4D PTHR11711:SF137 ADP RIBOSYLATION FACTOR-RELATED ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 4D guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;small molecule binding#GO:0036094;anion binding#GO:0043168;guanyl nucleotide binding#GO:0019001;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;nucleotide binding#GO:0000166;carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;ribonucleotide binding#GO:0032553 vesicle-mediated transport#GO:0016192;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule localization#GO:0033036;intracellular protein localization#GO:0008104;protein transport#GO:0015031;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886 G-protein#PC00020 Huntington disease#P00029>ARF#P00786 HUMAN|HGNC=12739|UniProtKB=O75554 O75554 WBP4 PTHR13173:SF10 WW DOMAIN BINDING PROTEIN 4 WW DOMAIN-BINDING PROTEIN 4 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;RNA biosynthetic process#GO:0032774;biosynthetic process#GO:0009058 spliceosomal complex#GO:0005681;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;precatalytic spliceosome#GO:0071011;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=8987|UniProtKB=Q9P1W9 Q9P1W9 PIM2 PTHR22984:SF10 SERINE/THREONINE-PROTEIN KINASE PIM SERINE_THREONINE-PROTEIN KINASE PIM-2 catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674 regulation of cell communication#GO:0010646;regulation of cell cycle#GO:0051726;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of programmed cell death#GO:0043067;positive regulation of signal transduction#GO:0009967;negative regulation of biological process#GO:0048519;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;negative regulation of apoptotic process#GO:0043066;regulation of canonical NF-kappaB signal transduction#GO:0043122;regulation of mitotic cell cycle#GO:0007346;negative regulation of programmed cell death#GO:0043069;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of canonical NF-kappaB signal transduction#GO:0043123;regulation of response to stimulus#GO:0048583;regulation of apoptotic process#GO:0042981;positive regulation of intracellular signal transduction#GO:1902533;negative regulation of cellular process#GO:0048523 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=31108|UniProtKB=P60606 P60606 CTXN1 PTHR16736:SF3 CORTEXIN-1-RELATED CORTEXIN-1 HUMAN|HGNC=18956|UniProtKB=Q969S2 Q969S2 NEIL2 PTHR22993:SF29 FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE ENDONUCLEASE 8-LIKE 2 endonuclease activity#GO:0004519;hydrolase activity, acting on glycosyl bonds#GO:0016798;catalytic activity, acting on DNA#GO:0140097;DNA nuclease activity#GO:0004536;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;nuclease activity#GO:0004518;DNA endonuclease activity#GO:0004520;hydrolase activity#GO:0016787;DNA N-glycosylase activity#GO:0019104 nucleobase-containing compound metabolic process#GO:0006139;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;base-excision repair#GO:0006284;response to stress#GO:0006950;macromolecule metabolic process#GO:0043170;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA glycosylase#PC00010 HUMAN|HGNC=29282|UniProtKB=Q9P270 Q9P270 SLAIN2 PTHR22406:SF4 NASCENT POLYPEPTIDE-ASSOCIATED COMPLEX SUBUNIT ALPHA, MUSCLE-SPECIFIC FORM SLAIN MOTIF-CONTAINING PROTEIN 2 microtubule cytoskeleton organization#GO:0000226;supramolecular fiber organization#GO:0097435;regulation of microtubule-based process#GO:0032886;regulation of cytoskeleton organization#GO:0051493;regulation of protein polymerization#GO:0032271;regulation of cellular process#GO:0050794;regulation of supramolecular fiber organization#GO:1902903;microtubule polymerization#GO:0046785;regulation of microtubule polymerization or depolymerization#GO:0031110;positive regulation of protein polymerization#GO:0032273;biological regulation#GO:0065007;microtubule polymerization or depolymerization#GO:0031109;positive regulation of cellular process#GO:0048522;positive regulation of organelle organization#GO:0010638;regulation of microtubule polymerization#GO:0031113;positive regulation of cellular component organization#GO:0051130;regulation of cellular component organization#GO:0051128;cytoplasmic microtubule organization#GO:0031122;regulation of cellular component biogenesis#GO:0044087;microtubule nucleation#GO:0007020;cellular component organization#GO:0016043;regulation of protein-containing complex assembly#GO:0043254;protein polymerization#GO:0051258;regulation of biological process#GO:0050789;protein-containing complex assembly#GO:0065003;regulation of organelle organization#GO:0033043;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;protein-containing complex organization#GO:0043933;cellular component assembly#GO:0022607;positive regulation of cellular component biogenesis#GO:0044089;cytoskeleton organization#GO:0007010;regulation of microtubule cytoskeleton organization#GO:0070507;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;positive regulation of biological process#GO:0048518;cellular process#GO:0009987 intracellular membraneless organelle#GO:0043232;supramolecular complex#GO:0099080;organelle#GO:0043226;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;microtubule end#GO:1990752;microtubule cytoskeleton#GO:0015630;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule plus-end#GO:0035371;microtubule#GO:0005874;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 HUMAN|HGNC=8696|UniProtKB=Q9Y5H4 Q9Y5H4 PCDHGA1 PTHR24028:SF108 CADHERIN-87A PROTOCADHERIN GAMMA-A1 cellular process#GO:0009987;cell adhesion#GO:0007155 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 cadherin#PC00057;cell adhesion molecule#PC00069 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HUMAN|HGNC=27915|UniProtKB=Q8IYL3 Q8IYL3 C1orf174 PTHR28491:SF1 UPF0688 PROTEIN C1ORF174 UPF0688 PROTEIN C1ORF174 HUMAN|HGNC=25514|UniProtKB=Q3KQU3 Q3KQU3 MAP7D1 PTHR15073:SF2 MICROTUBULE-ASSOCIATED PROTEIN MAP7 DOMAIN-CONTAINING PROTEIN 1 organelle organization#GO:0006996;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;cellular process#GO:0009987;regulation of microtubule-based movement#GO:0060632;regulation of cellular process#GO:0050794;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;regulation of microtubule-based process#GO:0032886;microtubule bundle formation#GO:0001578;cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226;microtubule-based process#GO:0007017 intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microtubule cytoskeleton#GO:0015630;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 non-motor microtubule binding protein#PC00166 HUMAN|HGNC=28646|UniProtKB=Q8IY84 Q8IY84 NIM1K PTHR24343:SF0 SERINE/THREONINE KINASE SERINE_THREONINE-PROTEIN KINASE NIM1 catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=10783|UniProtKB=Q01130 Q01130 SRSF2 PTHR23147:SF145 SERINE/ARGININE RICH SPLICING FACTOR SERINE_ARGININE-RICH SPLICING FACTOR 2 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear speck#GO:0016607;membraneless organelle#GO:0043228;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;nuclear body#GO:0016604;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 RNA processing factor#PC00147;RNA metabolism protein#PC00031;RNA splicing factor#PC00148 HUMAN|HGNC=10944|UniProtKB=P48664 P48664 SLC1A6 PTHR11958:SF67 SODIUM/DICARBOXYLATE SYMPORTER-RELATED EXCITATORY AMINO ACID TRANSPORTER 4 symporter activity#GO:0015293;monoatomic cation transmembrane transporter activity#GO:0008324;sodium:dicarboxylate symporter activity#GO:0017153;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;amino acid transmembrane transporter activity#GO:0015171;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;carboxylic acid transmembrane transporter activity#GO:0046943;amino acid:sodium symporter activity#GO:0005283;solute:sodium symporter activity#GO:0015370;transmembrane transporter activity#GO:0022857;neutral L-amino acid transmembrane transporter activity#GO:0015175;active transmembrane transporter activity#GO:0022804;L-amino acid transmembrane transporter activity#GO:0015179;acidic amino acid transmembrane transporter activity#GO:0015172;sodium ion transmembrane transporter activity#GO:0015081;L-glutamate transmembrane transporter activity#GO:0005313;dicarboxylic acid transmembrane transporter activity#GO:0005310;solute:monoatomic cation symporter activity#GO:0015294 L-alpha-amino acid transmembrane transport#GO:1902475;carboxylic acid transmembrane transport#GO:1905039;L-glutamate import#GO:0051938;localization#GO:0051179;amino acid transmembrane transport#GO:0003333;transmembrane transport#GO:0055085;cellular process#GO:0009987;L-amino acid transport#GO:0015807;nitrogen compound transport#GO:0071705;L-glutamate transmembrane transport#GO:0015813;dicarboxylic acid transport#GO:0006835;amino acid transport#GO:0006865;carboxylic acid transport#GO:0046942;organic acid transport#GO:0015849;acidic amino acid transport#GO:0015800;transport#GO:0006810;establishment of localization#GO:0051234 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 primary active transporter#PC00068 Metabotropic glutamate receptor group III pathway#P00039>EAAT#P01036;Ionotropic glutamate receptor pathway#P00037>EAAT#P01011 HUMAN|HGNC=20178|UniProtKB=Q86VE0 Q86VE0 MYPOP PTHR32345:SF3 MYB-RELATED TRANSCRIPTION FACTOR, PARTNER OF PROFILIN MYB-RELATED TRANSCRIPTION FACTOR, PARTNER OF PROFILIN sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119 HUMAN|HGNC=4572|UniProtKB=P42262 P42262 GRIA2 PTHR18966:SF99 IONOTROPIC GLUTAMATE RECEPTOR GLUTAMATE RECEPTOR 2 ligand-gated monoatomic ion channel activity#GO:0015276;carboxylic acid transmembrane transporter activity#GO:0046943;molecular transducer activity#GO:0060089;channel activity#GO:0015267;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;glutamate receptor activity#GO:0008066;transmembrane transporter activity#GO:0022857;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;dicarboxylic acid transmembrane transporter activity#GO:0005310;transmembrane signaling receptor activity#GO:0004888;gated channel activity#GO:0022836;amino acid transmembrane transporter activity#GO:0015171;neurotransmitter receptor activity#GO:0030594;transporter activity#GO:0005215;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;signaling receptor activity#GO:0038023 regulation of signaling#GO:0023051;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;modulation of chemical synaptic transmission#GO:0050804;signaling#GO:0023052;regulation of cell communication#GO:0010646;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;cellular process#GO:0009987;synaptic signaling#GO:0099536;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;synaptic transmission, glutamatergic#GO:0035249;regulation of trans-synaptic signaling#GO:0099177 neuron to neuron synapse#GO:0098984;monoatomic ion channel complex#GO:0034702;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;membrane#GO:0016020;cell periphery#GO:0071944;signaling receptor complex#GO:0043235;asymmetric synapse#GO:0032279;plasma membrane bounded cell projection#GO:0120025;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;transmembrane transporter complex#GO:1902495;postsynaptic density membrane#GO:0098839;dendrite#GO:0030425;postsynaptic density#GO:0014069;dendritic tree#GO:0097447;protein-containing complex#GO:0032991;neuron projection#GO:0043005;transporter complex#GO:1990351;cell junction#GO:0030054;synaptic membrane#GO:0097060;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;neuron spine#GO:0044309;cell projection#GO:0042995;postsynapse#GO:0098794;dendritic spine#GO:0043197;postsynaptic specialization membrane#GO:0099634;postsynaptic membrane#GO:0045211 transmembrane signal receptor#PC00197 Ionotropic glutamate receptor pathway#P00037>Glu2#P01017;Ionotropic glutamate receptor pathway#P00037>AMPA#P01019;Metabotropic glutamate receptor group III pathway#P00039>A/K#P01046;Ionotropic glutamate receptor pathway#P00037>A/K#P01025 HUMAN|HGNC=29605|UniProtKB=Q9UQQ2 Q9UQQ2 SH2B3 PTHR10872:SF1 SH2B ADAPTER PROTEIN SH2B ADAPTER PROTEIN 3 protein binding#GO:0005515;signaling adaptor activity#GO:0035591;protein-macromolecule adaptor activity#GO:0030674;binding#GO:0005488;kinase binding#GO:0019900;signaling receptor binding#GO:0005102;protein tyrosine kinase binding#GO:1990782;protein kinase binding#GO:0019901;transmembrane receptor protein tyrosine kinase adaptor activity#GO:0005068;enzyme binding#GO:0019899;molecular adaptor activity#GO:0060090;signaling receptor complex adaptor activity#GO:0030159;receptor tyrosine kinase binding#GO:0030971 cellular developmental process#GO:0048869;cell surface receptor signaling pathway#GO:0007166;regulation of response to stimulus#GO:0048583;developmental process#GO:0032502;negative regulation of response to stimulus#GO:0048585;response to cytokine#GO:0034097;response to chemical#GO:0042221;hemopoiesis#GO:0030097;biological regulation#GO:0065007;regulation of response to cytokine stimulus#GO:0060759;response to chemokine#GO:1990868;cellular process#GO:0009987;signal transduction#GO:0007165;anatomical structure development#GO:0048856;cell communication#GO:0007154;chemokine-mediated signaling pathway#GO:0070098;response to peptide#GO:1901652;intracellular signal transduction#GO:0035556;cytokine-mediated signaling pathway#GO:0019221;G protein-coupled receptor signaling pathway#GO:0007186;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;response to stimulus#GO:0050896;cellular response to chemokine#GO:1990869;cell development#GO:0048468;signaling#GO:0023052;negative regulation of response to cytokine stimulus#GO:0060761;negative regulation of biological process#GO:0048519;cellular response to stimulus#GO:0051716;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HUMAN|HGNC=29097|UniProtKB=Q66K14 Q66K14 TBC1D9B PTHR22957:SF225 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN TBC1 DOMAIN FAMILY MEMBER 9B enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 GTPase-activating protein#PC00257;protein-binding activity modulator#PC00095;G-protein modulator#PC00022 HUMAN|HGNC=25507|UniProtKB=Q08AM6 Q08AM6 VAC14 PTHR16023:SF0 TAX1 BINDING PROTEIN-RELATED PROTEIN VAC14 HOMOLOG metabolic process#GO:0008152;glycerophospholipid biosynthetic process#GO:0046474;phosphatidylinositol metabolic process#GO:0046488;lipid metabolic process#GO:0006629;glycerophospholipid metabolic process#GO:0006650;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;organophosphate biosynthetic process#GO:0090407;glycerolipid metabolic process#GO:0046486;phospholipid biosynthetic process#GO:0008654;phospholipid metabolic process#GO:0006644;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238 intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;endosome#GO:0005768;endosome membrane#GO:0010008;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;vesicle membrane#GO:0012506;membrane#GO:0016020;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;vacuole#GO:0005773;cytoplasm#GO:0005737;transferase complex#GO:1990234;vacuolar membrane#GO:0005774;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588 scaffold/adaptor protein#PC00226 HUMAN|HGNC=15347|UniProtKB=Q8NGC9 Q8NGC9 OR11H4 PTHR24242:SF381 G-PROTEIN COUPLED RECEPTOR OLFACTORY RECEPTOR 11H4 G-protein coupled receptor#PC00021 HUMAN|HGNC=28093|UniProtKB=A8MTZ0 A8MTZ0 BBIP1 PTHR28596:SF1 BBSOME-INTERACTING PROTEIN 1 BBSOME-INTERACTING PROTEIN 1 protein localization to cilium#GO:0061512;cell projection organization#GO:0030030;protein localization to organelle#GO:0033365;protein localization to membrane#GO:0072657;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cilium organization#GO:0044782;localization#GO:0051179;cellular localization#GO:0051641;localization within membrane#GO:0051668;organelle assembly#GO:0070925;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cell projection assembly#GO:0030031;cellular process#GO:0009987;macromolecule localization#GO:0033036;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;intracellular protein localization#GO:0008104;cellular component organization or biogenesis#GO:0071840;protein localization to cell periphery#GO:1990778;plasma membrane bounded cell projection assembly#GO:0120031 cilium#GO:0005929;cell projection membrane#GO:0031253;membrane-bounded organelle#GO:0043227;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane region#GO:0098590;BBSome#GO:0034464;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;ciliary membrane#GO:0060170 HUMAN|HGNC=26539|UniProtKB=Q5T197 Q5T197 DCST1 PTHR21041:SF17 DENDRITIC CELL-SPECIFIC TRANSMEMBRANE PROTEIN E3 UBIQUITIN-PROTEIN LIGASE DCST1 ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 sexual reproduction#GO:0019953;cell recognition#GO:0008037;sperm-egg recognition#GO:0035036;cell-cell recognition#GO:0009988;cellular process#GO:0009987;single fertilization#GO:0007338;reproductive process#GO:0022414;fertilization#GO:0009566 intracellular organelle#GO:0043229;acrosomal vesicle#GO:0001669;membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;vesicle#GO:0031982;intracellular vesicle#GO:0097708;secretory vesicle#GO:0099503;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 HUMAN|HGNC=28388|UniProtKB=Q8TC29 Q8TC29 ENKUR PTHR21490:SF0 ENKURIN-RELATED ENKURIN calmodulin binding#GO:0005516;binding#GO:0005488;protein binding#GO:0005515 supramolecular polymer#GO:0099081;ciliary plasm#GO:0097014;endomembrane system#GO:0012505;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;secretory vesicle#GO:0099503;microtubule cytoskeleton#GO:0015630;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;cellular anatomical structure#GO:0110165;axonemal microtubule#GO:0005879;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cytoplasmic microtubule#GO:0005881;intracellular vesicle#GO:0097708;vesicle#GO:0031982;axoneme#GO:0005930;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;supramolecular fiber#GO:0099512;acrosomal vesicle#GO:0001669;intracellular organelle#GO:0043229;cilium#GO:0005929 HUMAN|HGNC=15859|UniProtKB=Q9H6P5 Q9H6P5 TASP1 PTHR10188:SF8 L-ASPARAGINASE THREONINE ASPARTASE 1 catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity#GO:0003824 gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;protease#PC00190 HUMAN|HGNC=9453|UniProtKB=O43272 O43272 PRODH PTHR13914:SF0 PROLINE OXIDASE PROLINE DEHYDROGENASE-RELATED nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167;anion binding#GO:0043168;flavin adenine dinucleotide binding#GO:0050660;small molecule binding#GO:0036094;binding#GO:0005488;catalytic activity#GO:0003824;heterocyclic compound binding#GO:1901363;oxidoreductase activity#GO:0016491;nucleotide binding#GO:0000166 carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;amino acid metabolic process#GO:0006520;small molecule catabolic process#GO:0044282;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;proteinogenic amino acid metabolic process#GO:0170039;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739 oxidase#PC00175 Huntington disease#P00029>Proline oxidase#G01529 HUMAN|HGNC=29163|UniProtKB=Q9Y2I6 Q9Y2I6 NINL PTHR18905:SF12 NINEIN NINEIN-LIKE PROTEIN microtubule anchoring#GO:0034453;microtubule cytoskeleton organization#GO:0000226;microtubule anchoring at microtubule organizing center#GO:0072393;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;cytoskeleton organization#GO:0007010 microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;centrosome#GO:0005813;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 PDGF signaling pathway#P00047>GSK3#P01153 HUMAN|HGNC=27900|UniProtKB=Q0P5P2 Q0P5P2 C17orf67 PTHR48415:SF1 GENE 525-RELATED C17ORF67 HOMOLOG HUMAN|HGNC=30695|UniProtKB=Q8NI37 Q8NI37 PPTC7 PTHR12320:SF98 PROTEIN PHOSPHATASE 2C PROTEIN PHOSPHATASE PTC7 HOMOLOG regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;biological regulation#GO:0065007 mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195 HUMAN|HGNC=17107|UniProtKB=Q8NFU1 Q8NFU1 BEST2 PTHR10736:SF1 BESTROPHIN BESTROPHIN-2A monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic anion transmembrane transporter activity#GO:0008509;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;chloride channel activity#GO:0005254;chloride transmembrane transporter activity#GO:0015108;passive transmembrane transporter activity#GO:0022803;channel activity#GO:0015267;monoatomic anion channel activity#GO:0005253 monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220;monoatomic anion transport#GO:0006820;cellular process#GO:0009987;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;chloride transmembrane transport#GO:1902476;localization#GO:0051179;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698;chloride transport#GO:0006821;transport#GO:0006810 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=9047|UniProtKB=Q9UPG8 Q9UPG8 PLAGL2 PTHR24408:SF20 ZINC FINGER PROTEIN ZINC FINGER PROTEIN PLAGL2 sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=12902|UniProtKB=P17014 P17014 ZNF12 PTHR24377:SF1023 IP01015P-RELATED ZINC FINGER PROTEIN 12 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=15847|UniProtKB=P82980 P82980 RBP5 PTHR11955:SF74 FATTY ACID BINDING PROTEIN RETINOL-BINDING PROTEIN 5 lipid binding#GO:0008289;fatty acid binding#GO:0005504;organic acid binding#GO:0043177;small molecule binding#GO:0036094;binding#GO:0005488;carboxylic acid binding#GO:0031406;anion binding#GO:0043168;ion binding#GO:0043167 lipid localization#GO:0010876;carboxylic acid transport#GO:0046942;organic acid transport#GO:0015849;transport#GO:0006810;localization#GO:0051179;fatty acid transport#GO:0015908;establishment of localization#GO:0051234;monocarboxylic acid transport#GO:0015718;macromolecule localization#GO:0033036;lipid transport#GO:0006869 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cytosol#GO:0005829;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 transfer/carrier protein#PC00219 HUMAN|HGNC=903|UniProtKB=O15169 O15169 AXIN1 PTHR46102:SF3 AXIN AXIN-1 ubiquitin-like protein ligase binding#GO:0044389;ubiquitin protein ligase binding#GO:0031625;identical protein binding#GO:0042802;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;kinase binding#GO:0019900;binding#GO:0005488;beta-catenin binding#GO:0008013;protein binding#GO:0005515 anatomical structure development#GO:0048856;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434;regulation of protein catabolic process#GO:0042176;positive regulation of protein catabolic process#GO:0045732;positive regulation of ubiquitin-dependent protein catabolic process#GO:2000060;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of cell communication#GO:0010646;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;developmental process#GO:0032502;positive regulation of catabolic process#GO:0009896;cellular developmental process#GO:0048869;regulation of catabolic process#GO:0009894;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;negative regulation of Wnt signaling pathway#GO:0030178;negative regulation of response to stimulus#GO:0048585;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of canonical Wnt signaling pathway#GO:0090090;negative regulation of signaling#GO:0023057;positive regulation of protein metabolic process#GO:0051247;regulation of signaling#GO:0023051;positive regulation of metabolic process#GO:0009893;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;positive regulation of proteasomal protein catabolic process#GO:1901800;regulation of biological process#GO:0050789;cell differentiation#GO:0030154;cell development#GO:0048468;regulation of Wnt signaling pathway#GO:0030111;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;regulation of protein metabolic process#GO:0051246;regulation of canonical Wnt signaling pathway#GO:0060828;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;regulation of proteasomal protein catabolic process#GO:0061136;positive regulation of macromolecule metabolic process#GO:0010604;negative regulation of signal transduction#GO:0009968;positive regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032436 membrane#GO:0016020;nucleus#GO:0005634;cell periphery#GO:0071944;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 Wnt signaling pathway#P00057>Axin#P01429;Angiogenesis#P00005>Axin#P00253;Wnt signaling pathway#P00057>Wnt Target Genes#G01558 HUMAN|HGNC=53826|UniProtKB=Q6ZNX1 Q6ZNX1 SHLD3 PTHR41404:SF1 SHIELDIN COMPLEX SUBUNIT 3 SHIELDIN COMPLEX SUBUNIT 3 positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604;negative regulation of double-strand break repair via homologous recombination#GO:2000042;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of DNA metabolic process#GO:0051052;regulation of double-strand break repair via homologous recombination#GO:0010569;negative regulation of metabolic process#GO:0009892;regulation of DNA recombination#GO:0000018;positive regulation of metabolic process#GO:0009893;regulation of cellular response to stress#GO:0080135;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of response to stimulus#GO:0048584;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of response to stimulus#GO:0048585;biological regulation#GO:0065007;positive regulation of DNA repair#GO:0045739;negative regulation of DNA metabolic process#GO:0051053;negative regulation of cellular process#GO:0048523;regulation of response to stress#GO:0080134;regulation of DNA repair#GO:0006282;regulation of response to stimulus#GO:0048583;positive regulation of DNA metabolic process#GO:0051054;negative regulation of DNA recombination#GO:0045910;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of double-strand break repair#GO:2000781;regulation of double-strand break repair#GO:2000779 chromosome#GO:0005694;site of double-strand break#GO:0035861;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;site of DNA damage#GO:0090734;membraneless organelle#GO:0043228 HUMAN|HGNC=31748|UniProtKB=Q6XE38 Q6XE38 SCGB1D4 PTHR11332:SF11 SECRETOGLOBIN FAMILY 1D SECRETOGLOBIN FAMILY 1D MEMBER 4 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 transfer/carrier protein#PC00219 HUMAN|HGNC=28455|UniProtKB=Q9H9R9 Q9H9R9 DBNDD1 PTHR16294:SF4 DYSTROBREVIN BINDING PROTEIN 1 DYSBINDIN DYSBINDIN DOMAIN-CONTAINING PROTEIN 1 regulation of biological process#GO:0050789;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cell communication#GO:0010646 HUMAN|HGNC=7865|UniProtKB=Q96S42 Q96S42 NODAL PTHR11848:SF159 TGF-BETA FAMILY NODAL HOMOLOG molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;cytokine activity#GO:0005125 cellular developmental process#GO:0048869;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;developmental process#GO:0032502;cell surface receptor signaling pathway#GO:0007166;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;biological regulation#GO:0065007;signal transduction#GO:0007165;cellular process#GO:0009987;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;activin receptor signaling pathway#GO:0032924;cell differentiation#GO:0030154;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 growth factor#PC00112 TGF-beta signaling pathway#P00052>TGFbeta#P01286 HUMAN|HGNC=15212|UniProtKB=Q9H346 Q9H346 OR52D1 PTHR26450:SF391 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 52D1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=19089|UniProtKB=Q8TAD4 Q8TAD4 SLC30A5 PTHR45755:SF1 FAMILY NOT NAMED PROTON-COUPLED ZINC ANTIPORTER SLC30A5 monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation transmembrane transporter activity#GO:0008324;metal ion transmembrane transporter activity#GO:0046873;zinc ion transmembrane transporter activity#GO:0005385;transition metal ion transmembrane transporter activity#GO:0046915;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;zinc ion transmembrane transport#GO:0071577;inorganic ion homeostasis#GO:0098771;transition metal ion transport#GO:0000041;homeostatic process#GO:0042592;metal ion transport#GO:0030001;intracellular monoatomic ion homeostasis#GO:0006873;establishment of localization#GO:0051234;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;chemical homeostasis#GO:0048878;transport#GO:0006810;monoatomic cation transmembrane transport#GO:0098655;zinc ion transport#GO:0006829;monoatomic ion transmembrane transport#GO:0034220;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;vesicle#GO:0031982;Golgi stack#GO:0005795;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;Golgi apparatus#GO:0005794;organelle membrane#GO:0031090;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;cytoplasm#GO:0005737;Golgi cis cisterna#GO:0000137;endomembrane system#GO:0012505;Golgi cisterna#GO:0031985 HUMAN|HGNC=15682|UniProtKB=Q8NDX5 Q8NDX5 PHC3 PTHR12247:SF88 POLYCOMB GROUP PROTEIN POLYHOMEOTIC-LIKE PROTEIN 3 histone binding#GO:0042393;chromatin binding#GO:0003682;binding#GO:0005488;protein binding#GO:0005515 regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear ubiquitin ligase complex#GO:0000152;organelle#GO:0043226;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ubiquitin ligase complex#GO:0000151;nucleus#GO:0005634;PcG protein complex#GO:0031519;protein-containing complex#GO:0032991;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;PRC1 complex#GO:0035102;nuclear protein-containing complex#GO:0140513 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=11034|UniProtKB=Q2Y0W8 Q2Y0W8 SLC4A8 PTHR11453:SF37 ANION EXCHANGE PROTEIN ELECTRONEUTRAL SODIUM BICARBONATE EXCHANGER 1 symporter activity#GO:0015293;solute:sodium symporter activity#GO:0015370;monoatomic cation transmembrane transporter activity#GO:0008324;chloride transmembrane transporter activity#GO:0015108;bicarbonate transmembrane transporter activity#GO:0015106;antiporter activity#GO:0015297;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;secondary active transmembrane transporter activity#GO:0015291;monoatomic anion transmembrane transporter activity#GO:0008509;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294;sodium ion transmembrane transporter activity#GO:0015081;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873 establishment of localization#GO:0051234;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;transport#GO:0006810;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;biological regulation#GO:0065007;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;localization#GO:0051179;transmembrane transport#GO:0055085;regulation of biological quality#GO:0065008;regulation of pH#GO:0006885;regulation of intracellular pH#GO:0051453;homeostatic process#GO:0042592;intracellular monoatomic ion homeostasis#GO:0006873 cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;plasma membrane#GO:0005886;membrane#GO:0016020;basal part of cell#GO:0045178;basolateral plasma membrane#GO:0016323;cell periphery#GO:0071944;basal plasma membrane#GO:0009925 secondary carrier transporter#PC00258 HUMAN|HGNC=4512|UniProtKB=Q9Y653 Q9Y653 ADGRG1 PTHR12011:SF318 ADHESION G-PROTEIN COUPLED RECEPTOR ADHESION G PROTEIN-COUPLED RECEPTOR G1 signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;heparin binding#GO:0008201;carbohydrate derivative binding#GO:0097367;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;glycosaminoglycan binding#GO:0005539;binding#GO:0005488 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=6141|UniProtKB=P08648 P08648 ITGA5 PTHR23220:SF3 INTEGRIN ALPHA INTEGRIN ALPHA-5 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 anatomical structure development#GO:0048856;angiogenesis#GO:0001525;cell-substrate adhesion#GO:0031589;cell communication#GO:0007154;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;cell-matrix adhesion#GO:0007160;cell adhesion#GO:0007155;regulation of cellular process#GO:0050794;circulatory system development#GO:0072359;response to stimulus#GO:0050896;signaling#GO:0023052;blood vessel morphogenesis#GO:0048514;integrin-mediated signaling pathway#GO:0007229;cellular response to stimulus#GO:0051716;blood vessel development#GO:0001568;tube morphogenesis#GO:0035239;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;multicellular organism development#GO:0007275;anatomical structure formation involved in morphogenesis#GO:0048646;vasculature development#GO:0001944;cell surface receptor signaling pathway#GO:0007166;developmental process#GO:0032502;multicellular organismal process#GO:0032501;tube development#GO:0035295;biological regulation#GO:0065007;cell-cell adhesion#GO:0098609;cellular process#GO:0009987;signal transduction#GO:0007165 cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;protein complex involved in cell adhesion#GO:0098636;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cell surface#GO:0009986;signaling receptor complex#GO:0043235;integrin complex#GO:0008305 cell adhesion molecule#PC00069;integrin#PC00126 Integrin signalling pathway#P00034>Integrin alpha#P00941 HUMAN|HGNC=25651|UniProtKB=Q9C0J8 Q9C0J8 WDR33 PTHR22836:SF0 WD40 REPEAT PROTEIN PRE-MRNA 3' END PROCESSING PROTEIN WDR33 intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;mRNA cleavage factor complex#GO:0005849;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;mRNA cleavage and polyadenylation specificity factor complex#GO:0005847 RNA metabolism protein#PC00031;RNA processing factor#PC00147 HUMAN|HGNC=26038|UniProtKB=O75204 O75204 TMEM127 PTHR28358:SF1 TRANSMEMBRANE PROTEIN 127 TRANSMEMBRANE PROTEIN 127 regulation of biological process#GO:0050789;regulation of TOR signaling#GO:0032006;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;regulation of intracellular signal transduction#GO:1902531;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051 membrane#GO:0016020;cellular anatomical structure#GO:0110165 HUMAN|HGNC=25551|UniProtKB=Q8ND04 Q8ND04 SMG8 PTHR13091:SF0 AMPLIFIED IN BREAST CANCER 2-RELATED NONSENSE-MEDIATED MRNA DECAY FACTOR SMG8 catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;RNA metabolic process#GO:0016070;RNA catabolic process#GO:0006401;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;nucleobase-containing compound catabolic process#GO:0034655;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;nucleic acid catabolic process#GO:0141188;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;metabolic process#GO:0008152;negative regulation of cellular process#GO:0048523;macromolecule catabolic process#GO:0009057;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay#GO:0000184 HUMAN|HGNC=17768|UniProtKB=O95551 O95551 TDP2 PTHR15822:SF28 TRAF AND TNF RECEPTOR-ASSOCIATED PROTEIN TYROSYL-DNA PHOSPHODIESTERASE 2 catalytic activity, acting on DNA#GO:0140097;phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;DNA binding#GO:0003677;nucleic acid binding#GO:0003676;binding#GO:0005488;single-stranded DNA binding#GO:0003697 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stress#GO:0006950;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;nucleobase-containing compound metabolic process#GO:0006139;response to stimulus#GO:0050896;DNA damage response#GO:0006974;cellular response to stress#GO:0033554;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170 intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;nuclear body#GO:0016604;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;membraneless organelle#GO:0043228;intracellular membrane-bounded organelle#GO:0043231;PML body#GO:0016605;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 HUMAN|HGNC=9902|UniProtKB=P52756 P52756 RBM5 PTHR13948:SF21 RNA-BINDING PROTEIN RNA-BINDING PROTEIN 5 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=13278|UniProtKB=Q9HCS5 Q9HCS5 EPB41L4A PTHR23280:SF4 4.1 G PROTEIN BAND 4.1-LIKE PROTEIN 4A actin or actin-binding cytoskeletal protein#PC00041;cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HUMAN|HGNC=27637|UniProtKB=Q5T8I3 Q5T8I3 EEIG2 PTHR21456:SF3 FAMILY WITH SEQUENCE SIMILARITY 102 EEIG FAMILY MEMBER 2 HUMAN|HGNC=2568|UniProtKB=Q13495 Q13495 MAMLD1 PTHR15275:SF0 CG1 PROTEIN/F18 MASTERMIND-LIKE DOMAIN-CONTAINING PROTEIN 1 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 HUMAN|HGNC=26020|UniProtKB=Q9NX61 Q9NX61 TMEM161A PTHR13624:SF4 RE42071P TRANSMEMBRANE PROTEIN 161A HUMAN|HGNC=30953|UniProtKB=Q96DT7 Q96DT7 ZBTB10 PTHR24414:SF27 F-BOX/KELCH-REPEAT PROTEIN SKIP4 ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 10 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription repressor activity#GO:0001217;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690 negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 non-motor actin binding protein#PC00165;cytoskeletal protein#PC00085 HUMAN|HGNC=8827|UniProtKB=Q96FA3 Q96FA3 PELI1 PTHR12098:SF4 E3 UBIQUITIN-PROTEIN LIGASE PELLINO-RELATED E3 UBIQUITIN-PROTEIN LIGASE PELLINO HOMOLOG 1 transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659 protein K48-linked ubiquitination#GO:0070936;metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;protein modification process#GO:0036211;cellular process#GO:0009987;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=30587|UniProtKB=Q8TAD8 Q8TAD8 SNIP1 PTHR23308:SF36 NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1 SMAD NUCLEAR-INTERACTING PROTEIN 1 molecular function regulator activity#GO:0098772;molecular function inhibitor activity#GO:0140678 RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396 nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;spliceosomal complex#GO:0005681;nucleus#GO:0005634 RNA splicing factor#PC00148 TGF-beta signaling pathway#P00052>Co-activators corepressors#P01282 HUMAN|HGNC=13027|UniProtKB=Q14588 Q14588 ZNF234 PTHR24377:SF1013 IP01015P-RELATED ZINC FINGER PROTEIN 234 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=18707|UniProtKB=Q7Z6J2 Q7Z6J2 TAMALIN PTHR15963:SF3 GENERAL RECEPTOR FOR PHOSPHOINOSITIDES 1-ASSOCIATED SCAFFOLD PROTEIN-RELATED PROTEIN TAMALIN cell communication#GO:0007154;regulation of biological quality#GO:0065008;response to stimulus#GO:0050896;regulation of receptor-mediated endocytosis#GO:0048259;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;cellular response to stimulus#GO:0051716;regulation of transport#GO:0051049;regulation of localization#GO:0032879;regulation of endocytosis#GO:0030100;biological regulation#GO:0065007;signal transduction#GO:0007165;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;glutamatergic synapse#GO:0098978;synapse#GO:0045202;cell junction#GO:0030054;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=19766|UniProtKB=A6NK59 A6NK59 ASB14 PTHR24121:SF28 NO MECHANORECEPTOR POTENTIAL C, ISOFORM D-RELATED ANKYRIN REPEAT AND SOCS BOX PROTEIN 14 HUMAN|HGNC=13524|UniProtKB=P53801 P53801 PTTG1IP PTHR15191:SF14 PROTEIN CBG20567 PITUITARY TUMOR-TRANSFORMING GENE 1 PROTEIN-INTERACTING PROTEIN intracellular protein localization#GO:0008104;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;import into nucleus#GO:0051170;macromolecule localization#GO:0033036;protein localization to nucleus#GO:0034504;nuclear transport#GO:0051169;protein transport#GO:0015031;protein import into nucleus#GO:0006606;localization#GO:0051179;cellular localization#GO:0051641;nucleocytoplasmic transport#GO:0006913;protein localization to organelle#GO:0033365 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=20876|UniProtKB=Q96S55 Q96S55 WRNIP1 PTHR13779:SF7 WERNER HELICASE-INTERACTING PROTEIN 1 FAMILY MEMBER ATPASE WRNIP1 catalytic activity, acting on DNA#GO:0140097;helicase activity#GO:0004386;DNA helicase activity#GO:0003678;molecular function regulator activity#GO:0098772;isomerase activity#GO:0016853;catalytic activity, acting on a nucleic acid#GO:0140640;enzyme activator activity#GO:0008047;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543;ATP-dependent activity, acting on DNA#GO:0008094;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;ATP-dependent activity#GO:0140657 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;DNA replication#GO:0006260;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;nucleic acid biosynthetic process#GO:0141187;DNA-templated DNA replication#GO:0006261;response to stress#GO:0006950;DNA biosynthetic process#GO:0071897;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;nucleobase-containing compound biosynthetic process#GO:0034654;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 DNA helicase#PC00011;DNA metabolism protein#PC00009 HUMAN|HGNC=31984|UniProtKB=B7ZAQ6 B7ZAQ6 GPHRA PTHR15948:SF8 G-PROTEIN COUPLED RECEPTOR 89-RELATED GOLGI PH REGULATOR A-RELATED gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;channel activity#GO:0015267;monoatomic anion channel activity#GO:0005253;voltage-gated channel activity#GO:0022832;monoatomic anion transmembrane transporter activity#GO:0008509;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;passive transmembrane transporter activity#GO:0022803;voltage-gated monoatomic anion channel activity#GO:0008308;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216 cellular homeostasis#GO:0019725;regulation of biological quality#GO:0065008;intracellular chemical homeostasis#GO:0055082;regulation of pH#GO:0006885;intracellular monoatomic cation homeostasis#GO:0030003;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;regulation of intracellular pH#GO:0051453;homeostatic process#GO:0042592;biological regulation#GO:0065007;monoatomic ion homeostasis#GO:0050801;intracellular monoatomic ion homeostasis#GO:0006873 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;cytoplasm#GO:0005737;endomembrane system#GO:0012505;membrane#GO:0016020;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;endoplasmic reticulum#GO:0005783;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;endoplasmic reticulum membrane#GO:0005789 G-protein coupled receptor#PC00021 HUMAN|HGNC=21294|UniProtKB=Q14681 Q14681 KCTD2 PTHR14958:SF22 POTASSIUM CHANNEL TETRAMERISATION DOMAIN CONTAINING PROTEIN BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD2 binding#GO:0005488;protein binding#GO:0005515 modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056 cytoplasm#GO:0005737;cullin-RING ubiquitin ligase complex#GO:0031461;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;ubiquitin ligase complex#GO:0000151;Cul3-RING ubiquitin ligase complex#GO:0031463 scaffold/adaptor protein#PC00226 HUMAN|HGNC=16666|UniProtKB=Q9HAQ2 Q9HAQ2 KIF9 PTHR24115:SF191 KINESIN-RELATED KINESIN-LIKE PROTEIN KIF9 hydrolase activity#GO:0016787;microtubule motor activity#GO:0003777;ATP hydrolysis activity#GO:0016887;polypeptide conformation or assembly isomerase activity#GO:0120544;microtubule binding#GO:0008017;isomerase activity#GO:0016853;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;tubulin binding#GO:0015631;macromolecular conformation isomerase activity#GO:0120543;protein binding#GO:0005515;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP-dependent activity#GO:0140657;cytoskeletal motor activity#GO:0003774;hydrolase activity, acting on acid anhydrides#GO:0016817;cytoskeletal protein binding#GO:0008092 microtubule-based process#GO:0007017;microtubule-based movement#GO:0007018;cellular process#GO:0009987 cytoskeleton#GO:0005856;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;organelle#GO:0043226;cellular anatomical structure#GO:0110165 microtubule or microtubule-binding cytoskeletal protein#PC00157;microtubule binding motor protein#PC00156 HUMAN|HGNC=7883|UniProtKB=Q9UM47 Q9UM47 NOTCH3 PTHR45836:SF17 SLIT HOMOLOG NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 3 generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;axonogenesis#GO:0007409;neuron development#GO:0048666;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;cell development#GO:0048468;signaling#GO:0023052;cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;cell differentiation#GO:0030154;response to stimulus#GO:0050896;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell surface receptor signaling pathway#GO:0007166;neuron differentiation#GO:0030182;cell projection morphogenesis#GO:0048858;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;signal transduction#GO:0007165;neuron projection development#GO:0031175;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;system development#GO:0048731;anatomical structure development#GO:0048856;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;neurogenesis#GO:0022008;neuron projection guidance#GO:0097485;cellular developmental process#GO:0048869;Notch signaling pathway#GO:0007219;axon development#GO:0061564;axon guidance#GO:0007411;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;multicellular organismal process#GO:0032501 signaling receptor complex#GO:0043235;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cell surface#GO:0009986 Notch signaling pathway#P00045>NIct#P01119;Notch signaling pathway#P00045>Notch#P01099;Alzheimer disease-presenilin pathway#P00004>NICD#P00122;Notch signaling pathway#P00045>Next#P01103;Alzheimer disease-presenilin pathway#P00004>Notch extracellular fragment#P00179;Alzheimer disease-presenilin pathway#P00004>Notch transmembrane fragment#P00135;Alzheimer disease-presenilin pathway#P00004>Notch C-terminal fragment#P00120;Alzheimer disease-presenilin pathway#P00004>Notch fragment#P00154;Notch signaling pathway#P00045>Ntm#P01114;Alzheimer disease-presenilin pathway#P00004>Notch#P00176;Notch signaling pathway#P00045>NIcs#P01120;Alzheimer disease-presenilin pathway#P00004>Notch N-terminal fragment#P00171 HUMAN|HGNC=18753|UniProtKB=Q8NI29 Q8NI29 FBXO27 PTHR12125:SF9 F-BOX ONLY PROTEIN 6-LIKE PROTEIN F-BOX ONLY PROTEIN 27 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=271|UniProtKB=Q9UKK3 Q9UKK3 PARP4 PTHR46530:SF1 PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP4 PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP4 glycosyltransferase activity#GO:0016757;pentosyltransferase activity#GO:0016763;NAD+ poly-ADP-ribosyltransferase activity#GO:0003950;catalytic activity#GO:0003824;transferase activity#GO:0016740 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260 FAS signaling pathway#P00020>PARP#P00600 HUMAN|HGNC=11169|UniProtKB=Q13425 Q13425 SNTB2 PTHR10554:SF8 SYNTROPHIN BETA-2-SYNTROPHIN cell junction#GO:0030054;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;synapse#GO:0045202;protein-containing complex#GO:0032991;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane protein complex#GO:0098796;dystrophin-associated glycoprotein complex#GO:0016010;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HUMAN|HGNC=590|UniProtKB=Q13490 Q13490 BIRC2 PTHR10044:SF79 INHIBITOR OF APOPTOSIS BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 2 aminoacyltransferase activity#GO:0016755;molecular function regulator activity#GO:0098772;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;enzyme regulator activity#GO:0030234;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746 regulation of post-translational protein modification#GO:1901873;positive regulation of metabolic process#GO:0009893;positive regulation of protein metabolic process#GO:0051247;regulation of cell cycle#GO:0051726;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of protein modification by small protein conjugation or removal#GO:1903320;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;regulation of protein modification process#GO:0031399;regulation of protein ubiquitination#GO:0031396;regulation of apoptotic process#GO:0042981;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;positive regulation of protein ubiquitination#GO:0031398;positive regulation of macromolecule metabolic process#GO:0010604;negative regulation of apoptotic process#GO:0043066;negative regulation of programmed cell death#GO:0043069;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 protease inhibitor#PC00191;protein-binding activity modulator#PC00095 Apoptosis signaling pathway#P00006>c-IAP1,2#P00264;CCKR signaling map#P06959>BIRC2#G07278 HUMAN|HGNC=3042|UniProtKB=Q9UKA8 Q9UKA8 RCAN3 PTHR10300:SF6 CALCIPRESSIN CALCIPRESSIN-3 phosphatase regulator activity#GO:0019208;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;protein phosphatase regulator activity#GO:0019888 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;intracellular signaling cassette#GO:0141124;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;calcium-mediated signaling#GO:0019722;intracellular signal transduction#GO:0035556 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 intercellular signal molecule#PC00207 HUMAN|HGNC=27049|UniProtKB=Q6IQ23 Q6IQ23 PLEKHA7 PTHR12752:SF4 PHOSPHOINOSITOL 3-PHOSPHATE-BINDING PROTEIN PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 7 cellular component assembly#GO:0022607;cell junction organization#GO:0034330;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;adherens junction organization#GO:0034332;cell-cell adhesion#GO:0098609;cellular component organization#GO:0016043;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;cell-cell junction maintenance#GO:0045217;cell-cell junction organization#GO:0045216;cell adhesion#GO:0007155 membrane protein complex#GO:0098796;membrane#GO:0016020;cell-cell junction#GO:0005911;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;apical junction complex#GO:0043296;adherens junction#GO:0005912;anchoring junction#GO:0070161;cell junction#GO:0030054 HUMAN|HGNC=1362|UniProtKB=Q9P0K9 Q9P0K9 FRRS1L PTHR46902:SF1 DOMON DOMAIN-CONTAINING PROTEIN FRRS1L DOMON DOMAIN-CONTAINING PROTEIN FRRS1L biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of biological quality#GO:0065008;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;regulation of postsynaptic membrane neurotransmitter receptor levels#GO:0099072 HUMAN|HGNC=17311|UniProtKB=O75928 O75928 PIAS2 PTHR10782:SF12 ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN E3 SUMO-PROTEIN LIGASE PIAS2 molecular function inhibitor activity#GO:0140678;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-like protein transferase activity#GO:0019787;SUMO transferase activity#GO:0019789;SUMO ligase activity#GO:0061665;acyltransferase activity#GO:0016746;molecular function regulator activity#GO:0098772;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740 macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;primary metabolic process#GO:0044238;protein modification process#GO:0036211;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of receptor signaling pathway via STAT#GO:1904892;negative regulation of cellular process#GO:0048523;regulation of receptor signaling pathway via JAK-STAT#GO:0046425;regulation of response to stimulus#GO:0048583;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of response to stimulus#GO:0048585;regulation of RNA biosynthetic process#GO:2001141;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;post-translational protein modification#GO:0043687;negative regulation of signaling#GO:0023057;protein modification by small protein conjugation or removal#GO:0070647;regulation of signaling#GO:0023051;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;protein modification by small protein conjugation#GO:0032446;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;metabolic process#GO:0008152;protein sumoylation#GO:0016925;cellular process#GO:0009987;negative regulation of signal transduction#GO:0009968 chromatin#GO:0000785;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228;organelle lumen#GO:0043233;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234 Interferon-gamma signaling pathway#P00035>PIAS#P00958;JAK/STAT signaling pathway#P00038>PIAS#P01031 HUMAN|HGNC=15934|UniProtKB=Q8IXH7 Q8IXH7 NELFCD PTHR12144:SF0 NEGATIVE ELONGATION FACTOR D NEGATIVE ELONGATION FACTOR C_D RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;regulation of DNA-templated transcription elongation#GO:0032784;regulation of transcription elongation by RNA polymerase II#GO:0034243;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934 nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;transcription elongation factor complex#GO:0008023;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 HUMAN|HGNC=791|UniProtKB=P18850 P18850 ATF6 PTHR46164:SF1 ATF6, ISOFORM C CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-6 ALPHA RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 signal transduction#GO:0007165;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;endoplasmic reticulum unfolded protein response#GO:0030968;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;response to stress#GO:0006950;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to topologically incorrect protein#GO:0035966;signaling#GO:0023052;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;cellular response to stress#GO:0033554;cellular response to topologically incorrect protein#GO:0035967;response to endoplasmic reticulum stress#GO:0034976;cellular response to unfolded protein#GO:0034620;intracellular signal transduction#GO:0035556;regulation of RNA metabolic process#GO:0051252;response to unfolded protein#GO:0006986;cell communication#GO:0007154;regulation of DNA-templated transcription#GO:0006355 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 Apoptosis signaling pathway#P00006>ATF#P00302 HUMAN|HGNC=6593|UniProtKB=P48742 P48742 LHX1 PTHR24208:SF106 LIM/HOMEOBOX PROTEIN LHX LIM_HOMEOBOX PROTEIN LHX1 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690 cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;nervous system development#GO:0007399;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;neuron differentiation#GO:0030182;developmental process#GO:0032502;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119 HUMAN|HGNC=35|UniProtKB=Q8WWZ7 Q8WWZ7 ABCA5 PTHR19229:SF100 ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA CHOLESTEROL TRANSPORTER ABCA5 ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657;molecular carrier activity#GO:0140104;lipid carrier activity#GO:0005319;active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 lipid transport#GO:0006869;localization#GO:0051179;establishment of localization#GO:0051234;transport#GO:0006810;lipid localization#GO:0010876;macromolecule localization#GO:0033036 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 ATP-binding cassette (ABC) transporter#PC00003 HUMAN|HGNC=24721|UniProtKB=Q9H6S0 Q9H6S0 YTHDC2 PTHR18934:SF213 ATP-DEPENDENT RNA HELICASE 3'-5' RNA HELICASE YTHDC2 nucleic acid binding#GO:0003676;binding#GO:0005488;ATP-dependent activity#GO:0140657;RNA binding#GO:0003723;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;macromolecular conformation isomerase activity#GO:0120543;helicase activity#GO:0004386;isomerase activity#GO:0016853 RNA metabolism protein#PC00031;RNA helicase#PC00032 HUMAN|HGNC=26723|UniProtKB=Q8N9M1 Q8N9M1 C19orf47 PTHR21359:SF1 DUF5577 DOMAIN-CONTAINING PROTEIN DUF5577 DOMAIN-CONTAINING PROTEIN HUMAN|HGNC=222|UniProtKB=Q9UKP5 Q9UKP5 ADAMTS6 PTHR13723:SF27 ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 6 catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metalloendopeptidase activity#GO:0004222;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175 extracellular structure organization#GO:0043062;proteolysis#GO:0006508;metabolic process#GO:0008152;extracellular matrix organization#GO:0030198;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;external encapsulating structure organization#GO:0045229;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012 metalloprotease#PC00153 HUMAN|HGNC=6079|UniProtKB=Q92835 Q92835 INPP5D PTHR46051:SF3 SH2 DOMAIN-CONTAINING PROTEIN PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 1 positive regulation of immune system process#GO:0002684;regulation of B cell activation#GO:0050864;positive regulation of biological process#GO:0048518;positive regulation of cell development#GO:0010720;regulation of multicellular organismal process#GO:0051239;negative regulation of signal transduction#GO:0009968;positive regulation of cell differentiation#GO:0045597;positive regulation of leukocyte activation#GO:0002696;negative regulation of biological process#GO:0048519;regulation of leukocyte activation#GO:0002694;regulation of biological process#GO:0050789;positive regulation of multicellular organismal process#GO:0051240;regulation of cell activation#GO:0050865;regulation of multicellular organismal development#GO:2000026;regulation of lymphocyte activation#GO:0051249;negative regulation of signaling#GO:0023057;regulation of myeloid cell differentiation#GO:0045637;regulation of bone resorption#GO:0045124;regulation of signaling#GO:0023051;negative regulation of cell communication#GO:0010648;regulation of bone remodeling#GO:0046850;positive regulation of cellular process#GO:0048522;regulation of cell development#GO:0060284;negative regulation of response to stimulus#GO:0048585;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of immune system process#GO:0002683;positive regulation of cell activation#GO:0050867;negative regulation of cellular process#GO:0048523;positive regulation of developmental process#GO:0051094;regulation of cell differentiation#GO:0045595;regulation of response to stimulus#GO:0048583;negative regulation of multicellular organismal process#GO:0051241;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of developmental process#GO:0050793;regulation of cell communication#GO:0010646;regulation of immune response#GO:0050776;positive regulation of lymphocyte activation#GO:0051251;regulation of hemopoiesis#GO:1903706;regulation of tissue remodeling#GO:0034103 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 HUMAN|HGNC=16407|UniProtKB=Q8NFV4 Q8NFV4 ABHD11 PTHR46118:SF4 PROTEIN ABHD11 SN-1-SPECIFIC DIACYLGLYCEROL LIPASE ABHD11 carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;hydrolase activity#GO:0016787 lipid metabolic process#GO:0006629;cellular process#GO:0009987;metabolic process#GO:0008152;primary metabolic process#GO:0044238 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739 HUMAN|HGNC=17088|UniProtKB=Q7Z460 Q7Z460 CLASP1 PTHR21567:SF28 CLASP CLIP-ASSOCIATING PROTEIN 1 cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;microtubule binding#GO:0008017;binding#GO:0005488;protein binding#GO:0005515 mitotic cell cycle process#GO:1903047;chromosome organization#GO:0051276;spindle organization#GO:0007051;establishment of localization#GO:0051234;establishment of spindle localization#GO:0051293;mitotic spindle assembly#GO:0090307;mitotic sister chromatid segregation#GO:0000070;organelle assembly#GO:0070925;organelle localization#GO:0051640;localization#GO:0051179;organelle fission#GO:0048285;microtubule cytoskeleton organization#GO:0000226;cell cycle#GO:0007049;microtubule cytoskeleton organization involved in mitosis#GO:1902850;mitotic cell cycle#GO:0000278;chromosome segregation#GO:0007059;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;establishment of mitotic spindle localization#GO:0040001;spindle assembly#GO:0051225;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;nuclear division#GO:0000280;spindle localization#GO:0051653;cellular localization#GO:0051641;mitotic nuclear division#GO:0140014;cell cycle process#GO:0022402;nuclear chromosome segregation#GO:0098813;membraneless organelle assembly#GO:0140694;sister chromatid segregation#GO:0000819;cellular component organization#GO:0016043;mitotic spindle organization#GO:0007052;establishment of organelle localization#GO:0051656 organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitotic spindle#GO:0072686;basal part of cell#GO:0045178;cytoplasmic microtubule#GO:0005881;chromosome#GO:0005694;kinetochore#GO:0000776;cell cortex#GO:0005938;microtubule#GO:0005874;spindle microtubule#GO:0005876;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687;intracellular organelle#GO:0043229;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630;condensed chromosome, centromeric region#GO:0000779;cell periphery#GO:0071944;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;microtubule organizing center#GO:0005815;spindle#GO:0005819;cytoskeleton#GO:0005856;condensed chromosome#GO:0000793;chromosome, centromeric region#GO:0000775 microtubule or microtubule-binding cytoskeletal protein#PC00157;non-motor microtubule binding protein#PC00166;cytoskeletal protein#PC00085 HUMAN|HGNC=55527|UniProtKB=Q8WZ04 Q8WZ04 TOMT PTHR43836:SF1 CATECHOL O-METHYLTRANSFERASE 1-RELATED TRANSMEMBRANE O-METHYLTRANSFERASE O-methyltransferase activity#GO:0008171;catalytic activity#GO:0003824;transferase activity#GO:0016740;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757 phenol-containing compound metabolic process#GO:0018958;cellular process#GO:0009987;amine metabolic process#GO:0009308;biogenic amine metabolic process#GO:0006576;catabolic process#GO:0009056;amine catabolic process#GO:0009310;metabolic process#GO:0008152;catecholamine metabolic process#GO:0006584 methyltransferase#PC00155 HUMAN|HGNC=14938|UniProtKB=Q969N2 Q969N2 PIGT PTHR12959:SF11 GPI TRANSAMIDASE COMPONENT PIG-T-RELATED GPI-ANCHOR TRANSAMIDASE COMPONENT PIGT macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;biosynthetic process#GO:0009058;GPI anchored protein biosynthesis#GO:0180046;protein maturation#GO:0051604;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238 organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;peptidase complex#GO:1905368;cytoplasm#GO:0005737;caspase complex#GO:0008303;membrane#GO:0016020;endoplasmic reticulum protein-containing complex#GO:0140534;organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;transferase complex#GO:1990234;endopeptidase complex#GO:1905369;endoplasmic reticulum#GO:0005783 HUMAN|HGNC=49392|UniProtKB=A6NF36 A6NF36 CCDC182 PTHR37364:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 182 COILED-COIL DOMAIN-CONTAINING PROTEIN 182 HUMAN|HGNC=15721|UniProtKB=Q9NRL3 Q9NRL3 STRN4 PTHR15653:SF1 STRIATIN STRIATIN-4 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of hippo signaling#GO:0035331;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;regulation of cell communication#GO:0010646;regulation of hippo signaling#GO:0035330;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of response to stimulus#GO:0048585 somatodendritic compartment#GO:0036477;cell projection#GO:0042995;neuronal cell body#GO:0043025;plasma membrane bounded cell projection#GO:0120025;synapse#GO:0045202;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;neuron projection#GO:0043005;cell body#GO:0044297;postsynapse#GO:0098794;cell junction#GO:0030054;dendritic tree#GO:0097447;dendrite#GO:0030425 HUMAN|HGNC=18190|UniProtKB=Q5T619 Q5T619 ZNF648 PTHR24388:SF119 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 648 double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=12109|UniProtKB=A0A0B4J235 A0A0B4J235 TRAV13-2 PTHR19433:SF117 T-CELL RECEPTOR ALPHA CHAIN V REGION-RELATED T CELL RECEPTOR ALPHA VARIABLE 13-2 response to stimulus#GO:0050896;response to other organism#GO:0051707;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to external stimulus#GO:0009605;response to bacterium#GO:0009617;response to biotic stimulus#GO:0009607 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=25406|UniProtKB=Q8N3J9 Q8N3J9 ZNF664 PTHR24384:SF30 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED ZINC FINGER PROTEIN 664 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218 HUMAN|HGNC=4182|UniProtKB=P32455 P32455 GBP1 PTHR10751:SF113 GUANYLATE BINDING PROTEIN GUANYLATE-BINDING PROTEIN 1 ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818 vesicle#GO:0031982;intracellular vesicle#GO:0097708;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410 heterotrimeric G-protein#PC00117;G-protein#PC00020 HUMAN|HGNC=18194|UniProtKB=Q70YC5 Q70YC5 ZNF365 PTHR15739:SF2 ZINC FINGER PROTEIN PROTEIN ZNF365 regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of response to stimulus#GO:0048583;regulation of DNA repair#GO:0006282;regulation of response to stress#GO:0080134;regulation of cell projection organization#GO:0031344;telomere maintenance#GO:0000723;chromosome organization#GO:0051276;regulation of plasma membrane bounded cell projection organization#GO:0120035;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of double-strand break repair#GO:2000779;telomere organization#GO:0032200;cellular process#GO:0009987;regulation of neuron projection development#GO:0010975;organelle organization#GO:0006996;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;regulation of DNA metabolic process#GO:0051052;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;regulation of cellular component organization#GO:0051128;regulation of double-strand break repair via homologous recombination#GO:0010569;regulation of DNA recombination#GO:0000018;regulation of cellular response to stress#GO:0080135 HUMAN|HGNC=10397|UniProtKB=P08708 P08708 RPS17 PTHR10732:SF14 40S RIBOSOMAL PROTEIN S17 SMALL RIBOSOMAL SUBUNIT PROTEIN ES17 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytosolic ribosome#GO:0022626;cytosol#GO:0005829;ribosome#GO:0005840;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytosolic small ribosomal subunit#GO:0022627;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;small ribosomal subunit#GO:0015935 ribosomal protein#PC00202 HUMAN|HGNC=5281|UniProtKB=P32314 P32314 FOXN2 PTHR13962:SF19 FORKHEAD BOX PROTEIN N3-LIKE PROTEIN-RELATED FORKHEAD BOX PROTEIN N2 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 winged helix/forkhead transcription factor#PC00246 HUMAN|HGNC=33762|UniProtKB=Q5W5W9 Q5W5W9 RESP18 PTHR17314:SF0 REGULATED ENDOCRINE SPECIFIC PROTEIN 18 REGULATED ENDOCRINE-SPECIFIC PROTEIN 18 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=6560|UniProtKB=Q8NES3 Q8NES3 LFNG PTHR10811:SF7 FRINGE-RELATED BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE LUNATIC FRINGE hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;catalytic activity#GO:0003824;acetylglucosaminyltransferase activity#GO:0008375;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757 regulation of signaling#GO:0023051;regulation of Notch signaling pathway#GO:0008593;regulation of response to stimulus#GO:0048583;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of biological process#GO:0050789 transferase#PC00220;glycosyltransferase#PC00111 Notch signaling pathway#P00045>Fringe#P01107 HUMAN|HGNC=26699|UniProtKB=Q86WS3 Q86WS3 OOSP2 PTHR14380:SF7 PLACENTA-SPECIFIC PROTEIN 1 OOCYTE-SECRETED PROTEIN 2 HUMAN|HGNC=26904|UniProtKB=Q6Q4G3 Q6Q4G3 LVRN PTHR11533:SF31 PROTEASE M1 ZINC METALLOPROTEASE AMINOPEPTIDASE Q metallopeptidase activity#GO:0008237;hydrolase activity#GO:0016787;metalloaminopeptidase activity#GO:0070006;exopeptidase activity#GO:0008238;aminopeptidase activity#GO:0004177;catalytic activity#GO:0003824;metalloexopeptidase activity#GO:0008235;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233 catabolic process#GO:0009056;cellular process#GO:0009987;peptide catabolic process#GO:0043171;primary metabolic process#GO:0044238;peptide metabolic process#GO:0006518;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;proteolysis#GO:0006508 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 metalloprotease#PC00153;protease#PC00190 HUMAN|HGNC=13146|UniProtKB=Q96N20 Q96N20 ZNF75A PTHR24381:SF268 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 75A sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=8630|UniProtKB=P30086 P30086 PEBP1 PTHR11362:SF171 PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 1 regulation of response to stimulus#GO:0048583;regulation of MAPK cascade#GO:0043408;negative regulation of cellular process#GO:0048523;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of response to stimulus#GO:0048585;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of MAPK cascade#GO:0043409;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794 protease inhibitor#PC00191 FGF signaling pathway#P00021>RKIP#P00630;EGF receptor signaling pathway#P00018>RKIP#P00548 HUMAN|HGNC=3010|UniProtKB=P42658 P42658 DPP6 PTHR11731:SF20 PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED A-TYPE POTASSIUM CHANNEL MODULATORY PROTEIN DPP6 molecular function regulator activity#GO:0098772;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;ion channel regulator activity#GO:0099106;catalytic activity#GO:0003824;channel regulator activity#GO:0016247;hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;potassium channel regulator activity#GO:0015459;transporter regulator activity#GO:0141108 biological regulation#GO:0065007;regulation of monoatomic ion transport#GO:0043269;cellular process#GO:0009987;regulation of monoatomic ion transmembrane transport#GO:0034765;regulation of transport#GO:0051049;regulation of localization#GO:0032879;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;regulation of monoatomic cation transmembrane transport#GO:1904062;regulation of metal ion transport#GO:0010959;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of transmembrane transport#GO:0034762;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;proteolysis#GO:0006508 transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;cation channel complex#GO:0034703;voltage-gated potassium channel complex#GO:0008076;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane protein complex#GO:0098796;membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797 serine protease#PC00203;protease#PC00190 HUMAN|HGNC=12843|UniProtKB=Q96TA2 Q96TA2 YME1L1 PTHR23076:SF144 METALLOPROTEASE M41 FTSH ATP-DEPENDENT ZINC METALLOPROTEASE YME1L1 catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;catalytic activity#GO:0003824;ATP-dependent activity#GO:0140657 protein metabolic process#GO:0019538;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;proteolysis#GO:0006508;protein catabolic process#GO:0030163;catabolic process#GO:0009056;protein quality control for misfolded or incompletely synthesized proteins#GO:0006515;mitochondrion organization#GO:0007005;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;organelle organization#GO:0006996;cellular process#GO:0009987 organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622 metalloprotease#PC00153 HUMAN|HGNC=12992|UniProtKB=P17024 P17024 ZNF20 PTHR24381:SF136 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 124-RELATED DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=14698|UniProtKB=P0DMU2 P0DMU2 OR8G3 PTHR48018:SF172 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 8G3 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 cell communication#GO:0007154;nervous system process#GO:0050877;sensory perception#GO:0007600;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052;regulation of cellular process#GO:0050794;sensory perception of smell#GO:0007608;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;cellular process#GO:0009987;signal transduction#GO:0007165 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=19315|UniProtKB=Q96KP6 Q96KP6 TNIP3 PTHR31882:SF2 TNFAIP3-INTERACTING PROTEIN COILED COIL FAMILY MEMBER TNFAIP3-INTERACTING PROTEIN 3 negative regulation of signal transduction#GO:0009968;response to chemical#GO:0042221;response to lipid#GO:0033993;cellular response to lipid#GO:0071396;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987;response to biotic stimulus#GO:0009607;cellular response to lipopolysaccharide#GO:0071222;response to lipopolysaccharide#GO:0032496;biological process involved in interspecies interaction between organisms#GO:0044419;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;response to molecule of bacterial origin#GO:0002237;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;response to oxygen-containing compound#GO:1901700;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;cellular response to chemical stimulus#GO:0070887;regulation of intracellular signal transduction#GO:1902531;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of RNA biosynthetic process#GO:2001141;response to other organism#GO:0051707;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of response to stimulus#GO:0048585;regulation of canonical NF-kappaB signal transduction#GO:0043122;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;response to external stimulus#GO:0009605;regulation of gene expression#GO:0010468;cellular response to molecule of bacterial origin#GO:0071219;regulation of biosynthetic process#GO:0009889;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;response to external biotic stimulus#GO:0043207;regulation of cell communication#GO:0010646;negative regulation of canonical NF-kappaB signal transduction#GO:0043124;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;cellular response to biotic stimulus#GO:0071216;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;response to bacterium#GO:0009617 HUMAN|HGNC=28208|UniProtKB=Q5SV97 Q5SV97 PERM1 PTHR47282:SF1 PGC-1 AND ERR-INDUCED REGULATOR IN MUSCLE PROTEIN 1 PGC-1 AND ERR-INDUCED REGULATOR IN MUSCLE PROTEIN 1 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;response to stimulus#GO:0050896;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HUMAN|HGNC=25636|UniProtKB=Q6DN12 Q6DN12 MCTP2 PTHR45911:SF2 C2 DOMAIN-CONTAINING PROTEIN MULTIPLE C2 AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 2 cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 regulation of trans-synaptic signaling#GO:0099177;regulation of neurotransmitter secretion#GO:0046928;regulation of cellular process#GO:0050794;modulation of chemical synaptic transmission#GO:0050804;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;regulation of biological process#GO:0050789;regulation of secretion#GO:0051046;regulation of localization#GO:0032879;regulation of transport#GO:0051049;regulation of secretion by cell#GO:1903530;regulation of neurotransmitter transport#GO:0051588;regulation of signaling#GO:0023051 intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;synaptic vesicle#GO:0008021;synaptic vesicle membrane#GO:0030672;vesicle#GO:0031982;intracellular vesicle#GO:0097708;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;cell junction#GO:0030054;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;transport vesicle membrane#GO:0030658;endomembrane system#GO:0012505;transport vesicle#GO:0030133;presynapse#GO:0098793;secretory vesicle#GO:0099503;membrane#GO:0016020;vesicle membrane#GO:0012506 HUMAN|HGNC=15530|UniProtKB=Q9NRJ4 Q9NRJ4 TULP4 PTHR16517:SF2 TUBBY-RELATED TUBBY-RELATED PROTEIN 4 localization#GO:0051179;protein localization to organelle#GO:0033365;protein localization to cilium#GO:0061512;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036 membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cilium#GO:0005929 scaffold/adaptor protein#PC00226 HUMAN|HGNC=33383|UniProtKB=A0PJZ3 A0PJZ3 GXYLT2 PTHR46012:SF1 IP22168P GLUCOSIDE XYLOSYLTRANSFERASE 2 UDP-glycosyltransferase activity#GO:0008194;xylosyltransferase activity#GO:0042285;glycosyltransferase activity#GO:0016757;UDP-xylosyltransferase activity#GO:0035252;pentosyltransferase activity#GO:0016763;catalytic activity#GO:0003824;transferase activity#GO:0016740 metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;cellular process#GO:0009987;protein O-linked glycosylation#GO:0006493;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;biosynthetic process#GO:0009058 HUMAN|HGNC=7523|UniProtKB=O94972 O94972 TRIM37 PTHR36754:SF2 E3 UBIQUITIN-PROTEIN LIGASE TRIM37 E3 UBIQUITIN-PROTEIN LIGASE TRIM37 catalytic activity, acting on a protein#GO:0140096;tumor necrosis factor receptor superfamily binding#GO:0032813;ubiquitin protein ligase binding#GO:0031625;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;ubiquitin-like protein ligase binding#GO:0044389;signaling receptor binding#GO:0005102;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;transferase activity#GO:0016740;protein binding#GO:0005515;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;binding#GO:0005488;cytokine receptor binding#GO:0005126;ubiquitin protein ligase activity#GO:0061630;enzyme binding#GO:0019899 cellular component assembly#GO:0022607;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;protein modification process#GO:0036211;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;protein modification by small protein conjugation#GO:0032446;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647 peroxisomal membrane#GO:0005778;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;peroxisome#GO:0005777;microbody#GO:0042579;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=6461|UniProtKB=Q9NSB2 Q9NSB2 KRT84 PTHR45616:SF17 GATA-TYPE DOMAIN-CONTAINING PROTEIN KERATIN, TYPE II CUTICULAR HB4 structural molecule activity#GO:0005198 cellular component organization#GO:0016043;intermediate filament cytoskeleton organization#GO:0045104;cell differentiation#GO:0030154;intermediate filament-based process#GO:0045103;animal gross anatomical part developmental process#GO:0160108;keratinocyte differentiation#GO:0030216;intermediate filament organization#GO:0045109;anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;organelle organization#GO:0006996;cellular process#GO:0009987;epithelium development#GO:0060429;epidermal cell differentiation#GO:0009913;multicellular organismal process#GO:0032501;epithelial cell differentiation#GO:0030855;tissue development#GO:0009888;cytoskeleton organization#GO:0007010;skin development#GO:0043588;epidermis development#GO:0008544;developmental process#GO:0032502;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;animal organ development#GO:0048513 intracellular anatomical structure#GO:0005622;intermediate filament#GO:0005882;supramolecular fiber#GO:0099512;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;organelle#GO:0043226;supramolecular complex#GO:0099080 HUMAN|HGNC=17423|UniProtKB=Q9NRB3 Q9NRB3 CHST12 PTHR12137:SF4 CARBOHYDRATE SULFOTRANSFERASE CARBOHYDRATE SULFOTRANSFERASE 12 transferase activity#GO:0016740;catalytic activity#GO:0003824;sulfotransferase activity#GO:0008146;transferase activity, transferring sulphur-containing groups#GO:0016782 glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;proteoglycan biosynthetic process#GO:0030166;biosynthetic process#GO:0009058;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;proteoglycan metabolic process#GO:0006029 transferase#PC00220 HUMAN|HGNC=28866|UniProtKB=Q9NZI8 Q9NZI8 IGF2BP1 PTHR10288:SF92 KH DOMAIN CONTAINING RNA BINDING PROTEIN INSULIN-LIKE GROWTH FACTOR 2 MRNA-BINDING PROTEIN 1 RNA binding#GO:0003723;mRNA 3'-UTR binding#GO:0003730;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729 regulation of RNA stability#GO:0043487;positive regulation of biosynthetic process#GO:0009891;anatomical structure development#GO:0048856;system development#GO:0048731;negative regulation of catabolic process#GO:0009895;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of RNA catabolic process#GO:1902369;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;positive regulation of gene expression#GO:0010628;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;animal gross anatomical part developmental process#GO:0160108;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;RNA stabilization#GO:0043489;regulation of biological quality#GO:0065008;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;regulation of biological process#GO:0050789;negative regulation of metabolic process#GO:0009892;regulation of mRNA stability#GO:0043488;negative regulation of RNA metabolic process#GO:0051253;multicellular organism development#GO:0007275;regulation of mRNA metabolic process#GO:1903311;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604;mRNA stabilization#GO:0048255;nervous system development#GO:0007399 organelle#GO:0043226;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cytosol#GO:0005829;nucleus#GO:0005634;membraneless organelle#GO:0043228;cytoplasmic stress granule#GO:0010494;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031 HUMAN|HGNC=44201|UniProtKB=P0DKL9 P0DKL9 ARL14EPL PTHR46804:SF4 ADP RIBOSYLATION FACTOR LIKE GTPASE 14 EFFECTOR PROTEIN LIKE ARL14 EFFECTOR PROTEIN-LIKE small GTPase#PC00208;G-protein#PC00020;protein-binding activity modulator#PC00095 HUMAN|HGNC=1527|UniProtKB=Q03135 Q03135 CAV1 PTHR10844:SF18 CAVEOLIN CAVEOLIN-1 protein binding#GO:0005515;transmembrane transporter binding#GO:0044325;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;binding#GO:0005488;kinase binding#GO:0019900 regulation of biological process#GO:0050789;membrane assembly#GO:0071709;regulation of cytosolic calcium ion concentration#GO:0051480;intracellular monoatomic ion homeostasis#GO:0006873;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;homeostatic process#GO:0042592;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;plasma membrane organization#GO:0007009;regulation of cell population proliferation#GO:0042127;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;monoatomic ion homeostasis#GO:0050801;negative regulation of cell population proliferation#GO:0008285;biological regulation#GO:0065007;membrane organization#GO:0061024;endomembrane system organization#GO:0010256;cellular component assembly#GO:0022607;developmental process#GO:0032502;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;negative regulation of cellular process#GO:0048523;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;cellular homeostasis#GO:0019725;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869 plasma membrane raft#GO:0044853;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell-substrate junction#GO:0030055;focal adhesion#GO:0005925;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;membrane raft#GO:0045121;vesicle#GO:0031982;sarcolemma#GO:0042383;cell junction#GO:0030054;Golgi apparatus#GO:0005794;membrane microdomain#GO:0098857;plasma membrane region#GO:0098590;endomembrane system#GO:0012505;perinuclear region of cytoplasm#GO:0048471;plasma membrane#GO:0005886;cytoplasm#GO:0005737;membrane#GO:0016020;caveola#GO:0005901;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 Gonadotropin-releasing hormone receptor pathway#P06664>Caveolin-1#P06763;Integrin signalling pathway#P00034>Caveolin#P00918 HUMAN|HGNC=24149|UniProtKB=Q9HCC6 Q9HCC6 HES4 PTHR10985:SF157 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED TRANSCRIPTION FACTOR HES-4 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677 regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of developmental process#GO:0050793;regulation of neurogenesis#GO:0050767;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of nervous system development#GO:0051960;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;pattern specification process#GO:0007389;regulation of nucleobase-containing compound metabolic process#GO:0019219;regionalization#GO:0003002;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;regulation of cell development#GO:0060284;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;regulation of cell differentiation#GO:0045595;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of multicellular organismal development#GO:2000026;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of multicellular organismal process#GO:0051239;negative regulation of macromolecule biosynthetic process#GO:0010558;multicellular organism development#GO:0007275;anterior/posterior pattern specification#GO:0009952;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 basic helix-loop-helix transcription factor#PC00055 Notch signaling pathway#P00045>E(spl)-C genes#G01541 HUMAN|HGNC=22180|UniProtKB=A4D2B0 A4D2B0 MBLAC1 PTHR23200:SF48 METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN 1 METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN 1 HUMAN|HGNC=14855|UniProtKB=Q8NGP2 Q8NGP2 OR8J1 PTHR48018:SF44 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 8J1 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;sensory perception#GO:0007600;nervous system process#GO:0050877;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;sensory perception of smell#GO:0007608 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=28129|UniProtKB=Q6UWU2 Q6UWU2 GLB1L PTHR23421:SF50 BETA-GALACTOSIDASE RELATED BETA-GALACTOSIDASE-1-LIKE PROTEIN hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 metabolic process#GO:0008152;monosaccharide metabolic process#GO:0005996;carbohydrate catabolic process#GO:0016052;hexose metabolic process#GO:0019318;primary metabolic process#GO:0044238;cellular process#GO:0009987;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;carbohydrate metabolic process#GO:0005975;small molecule catabolic process#GO:0044282 galactosidase#PC00104;hydrolase#PC00121 HUMAN|HGNC=17119|UniProtKB=Q9NPH9 Q9NPH9 IL26 PTHR48482:SF1 INTERLEUKIN-19-RELATED INTERLEUKIN-26 molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;signaling receptor regulator activity#GO:0030545;cytokine activity#GO:0005125;receptor ligand activity#GO:0048018 cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;regulation of response to external stimulus#GO:0032101;response to chemical#GO:0042221;response to cytokine#GO:0034097;negative regulation of response to external stimulus#GO:0032102;cell surface receptor signaling pathway#GO:0007166;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;response to stimulus#GO:0050896;signaling#GO:0023052;immune system process#GO:0002376;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;response to peptide#GO:1901652;immune response#GO:0006955;positive regulation of cellular process#GO:0048522;negative regulation of response to stimulus#GO:0048585;positive regulation of response to stimulus#GO:0048584;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of response to stress#GO:0080134;regulation of response to stimulus#GO:0048583;regulation of receptor signaling pathway via JAK-STAT#GO:0046425;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;negative regulation of defense response#GO:0031348;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;negative regulation of inflammatory response#GO:0050728;regulation of receptor signaling pathway via STAT#GO:1904892;regulation of cell communication#GO:0010646;positive regulation of receptor signaling pathway via JAK-STAT#GO:0046427;cytokine-mediated signaling pathway#GO:0019221;regulation of defense response#GO:0031347;regulation of inflammatory response#GO:0050727;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=3033|UniProtKB=P54259 P54259 ATN1 PTHR13859:SF9 ATROPHIN-RELATED ATROPHIN-1 transcription regulator activity#GO:0140110;transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=28403|UniProtKB=Q8TBZ6 Q8TBZ6 TRMT10A PTHR13563:SF20 TRNA (GUANINE-9-) METHYLTRANSFERASE TRNA METHYLTRANSFERASE 10 HOMOLOG A binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;tRNA binding#GO:0000049 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;tRNA methylation#GO:0030488;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;tRNA modification#GO:0006400;macromolecule methylation#GO:0043414;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;methylation#GO:0032259;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;RNA methylation#GO:0001510 nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 RNA methyltransferase#PC00033;RNA metabolism protein#PC00031 HUMAN|HGNC=20985|UniProtKB=Q99990 Q99990 VGLL1 PTHR15950:SF20 TRANSCRIPTION COFACTOR VESTIGIAL-LIKE PROTEIN TRANSCRIPTION COFACTOR VESTIGIAL-LIKE PROTEIN 1 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 transcription cofactor#PC00217;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=18304|UniProtKB=Q14019 Q14019 COTL1 PTHR10829:SF25 CORTACTIN AND DREBRIN COACTOSIN-LIKE PROTEIN protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;actin filament binding#GO:0051015 regulation of biological quality#GO:0065008;regulation of actin filament length#GO:0030832;regulation of cellular component biogenesis#GO:0044087;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;regulation of protein polymerization#GO:0032271;regulation of cellular process#GO:0050794;regulation of cellular component size#GO:0032535;regulation of biological process#GO:0050789;regulation of supramolecular fiber organization#GO:1902903;regulation of organelle organization#GO:0033043;cellular component organization#GO:0016043;regulation of protein-containing complex assembly#GO:0043254;cellular component organization or biogenesis#GO:0071840;regulation of anatomical structure size#GO:0090066;regulation of actin filament-based process#GO:0032970;regulation of actin polymerization or depolymerization#GO:0008064;biological regulation#GO:0065007;regulation of actin cytoskeleton organization#GO:0032956;regulation of actin filament polymerization#GO:0030833;cellular process#GO:0009987;regulation of actin filament organization#GO:0110053 intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cortical cytoskeleton#GO:0030863;actin cytoskeleton#GO:0015629;cell cortex#GO:0005938;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cytoskeleton#GO:0005856;actin filament#GO:0005884;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;cortical actin cytoskeleton#GO:0030864;intracellular membraneless organelle#GO:0043232;cell periphery#GO:0071944 non-motor actin binding protein#PC00165;cytoskeletal protein#PC00085 HUMAN|HGNC=29448|UniProtKB=Q9BY31 Q9BY31 ZNF717 PTHR24376:SF233 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 268-RELATED negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=10583|UniProtKB=Q9UI33 Q9UI33 SCN11A PTHR10037:SF210 VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM SODIUM CHANNEL PROTEIN TYPE 11 SUBUNIT ALPHA passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;sodium channel activity#GO:0005272;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;voltage-gated sodium channel activity#GO:0005248;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267 sodium ion transport#GO:0006814;action potential#GO:0001508;sensory perception of pain#GO:0019233;membrane depolarization#GO:0051899;metal ion transport#GO:0030001;nervous system process#GO:0050877;sensory perception#GO:0007600;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transmembrane transport#GO:0098655;multicellular organismal process#GO:0032501;transport#GO:0006810;system process#GO:0003008;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391 cation channel complex#GO:0034703;transporter complex#GO:1990351;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;axon#GO:0030424;transmembrane transporter complex#GO:1902495;sodium channel complex#GO:0034706;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025 voltage-gated ion channel#PC00241 HUMAN|HGNC=30367|UniProtKB=Q8WXG8 Q8WXG8 S100Z PTHR11639:SF72 S100 CALCIUM-BINDING PROTEIN PROTEIN S100-Z protein binding#GO:0005515;metal ion binding#GO:0046872;cation binding#GO:0043169;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;calcium ion binding#GO:0005509 calmodulin-related#PC00061;calcium-binding protein#PC00060 HUMAN|HGNC=6643|UniProtKB=Q8TAP4 Q8TAP4 LMO3 PTHR45787:SF7 LD11652P LIM DOMAIN ONLY PROTEIN 3 transcription coactivator activity#GO:0003713;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=7183|UniProtKB=P41218 P41218 MNDA PTHR12200:SF27 INTERFERON-INDUCIBLE PROTEIN AIM2 FAMILY MEMBER MYELOID CELL NUCLEAR DIFFERENTIATION ANTIGEN binding#GO:0005488;nucleic acid binding#GO:0003676;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690 biological regulation#GO:0065007;regulation of response to external stimulus#GO:0032101;response to chemical#GO:0042221;positive regulation of response to stimulus#GO:0048584;response to cytokine#GO:0034097;positive regulation of innate immune response#GO:0045089;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;positive regulation of immune system process#GO:0002684;activation of innate immune response#GO:0002218;positive regulation of response to biotic stimulus#GO:0002833;positive regulation of response to external stimulus#GO:0032103;regulation of innate immune response#GO:0045088;regulation of response to stimulus#GO:0048583;positive regulation of defense response#GO:0031349;positive regulation of immune response#GO:0050778;regulation of response to stress#GO:0080134;regulation of response to biotic stimulus#GO:0002831;regulation of immune system process#GO:0002682;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;response to peptide#GO:1901652;regulation of defense response#GO:0031347;regulation of immune response#GO:0050776;immune system process#GO:0002376 organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular organelle#GO:0043229;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;cytosol#GO:0005829;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membraneless organelle#GO:0043228 DNA-binding transcription factor#PC00218 HUMAN|HGNC=28082|UniProtKB=Q3KQV9 Q3KQV9 UAP1L1 PTHR11952:SF6 UDP- GLUCOSE PYROPHOSPHORYLASE UDP-N-ACETYLHEXOSAMINE PYROPHOSPHORYLASE-LIKE PROTEIN 1 transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;nucleotidyltransferase activity#GO:0016779 nucleobase-containing small molecule metabolic process#GO:0055086;nucleoside phosphate biosynthetic process#GO:1901293;carbohydrate derivative biosynthetic process#GO:1901137;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;nucleotide-sugar metabolic process#GO:0009225;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;UDP-N-acetylglucosamine metabolic process#GO:0006047;organophosphate biosynthetic process#GO:0090407;UDP-N-acetylglucosamine biosynthetic process#GO:0006048;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;amino sugar metabolic process#GO:0006040;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 HUMAN|HGNC=31673|UniProtKB=A8MXD5 A8MXD5 GRXCR1 PTHR46990:SF1 GLUTAREDOXIN DOMAIN-CONTAINING CYSTEINE-RICH PROTEIN 1 GLUTAREDOXIN DOMAIN-CONTAINING CYSTEINE-RICH PROTEIN 1 cellular component organization#GO:0016043;inner ear receptor cell stereocilium organization#GO:0060122;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell development#GO:0048468;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;anatomical structure development#GO:0048856;ear development#GO:0043583;neuron development#GO:0048666;system development#GO:0048731;inner ear development#GO:0048839;neuron projection development#GO:0031175;cellular process#GO:0009987;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;sensory organ development#GO:0007423;developmental process#GO:0032502;neuron differentiation#GO:0030182;cellular developmental process#GO:0048869;animal organ development#GO:0048513;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;neurogenesis#GO:0022008 intracellular membraneless organelle#GO:0043232;neuron projection#GO:0043005;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;stereocilium#GO:0032420;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;actin cytoskeleton#GO:0015629;actin-based cell projection#GO:0098858;intracellular anatomical structure#GO:0005622;non-motile cilium#GO:0097730;membrane-bounded organelle#GO:0043227;cluster of actin-based cell projections#GO:0098862;intracellular organelle#GO:0043229;cilium#GO:0005929 oxidoreductase#PC00176 HUMAN|HGNC=26202|UniProtKB=Q6IN84 Q6IN84 MRM1 PTHR46103:SF3 RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring one-carbon groups#GO:0016741;rRNA methyltransferase activity#GO:0008649;catalytic activity, acting on RNA#GO:0140098;RNA methyltransferase activity#GO:0008173;rRNA (guanine) methyltransferase activity#GO:0016435;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;catalytic activity, acting on a rRNA#GO:0140102 RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;rRNA processing#GO:0006364;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;rRNA modification#GO:0000154;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;gene expression#GO:0010467;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739 RNA methyltransferase#PC00033 HUMAN|HGNC=10414|UniProtKB=P62854 P62854 RPS26 PTHR12538:SF7 40S RIBOSOMAL PROTEIN S26 SMALL RIBOSOMAL SUBUNIT PROTEIN ES26-RELATED structural molecule activity#GO:0005198;RNA binding#GO:0003723;mRNA binding#GO:0003729;structural constituent of ribosome#GO:0003735;binding#GO:0005488;nucleic acid binding#GO:0003676 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;small ribosomal subunit#GO:0015935;ribonucleoprotein complex#GO:1990904;cytosolic small ribosomal subunit#GO:0022627;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;ribosome#GO:0005840;cytosolic ribosome#GO:0022626;cytosol#GO:0005829 ribosomal protein#PC00202;translational protein#PC00263 HUMAN|HGNC=18028|UniProtKB=Q9NPF4 Q9NPF4 OSGEP PTHR11735:SF14 TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE catalytic complex#GO:1902494;transferase complex#GO:1990234;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HUMAN|HGNC=1137|UniProtKB=Q8WVV5 Q8WVV5 BTN2A2 PTHR24100:SF156 BUTYROPHILIN BUTYROPHILIN SUBFAMILY 2 MEMBER A2 protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488 cell surface receptor signaling pathway#GO:0007166;immune response-activating signaling pathway#GO:0002757;positive regulation of immune system process#GO:0002684;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;cellular process#GO:0009987;antigen receptor-mediated signaling pathway#GO:0050851;regulation of multicellular organismal process#GO:0051239;immune system process#GO:0002376;regulation of biological process#GO:0050789;immune response-regulating signaling pathway#GO:0002764;response to stimulus#GO:0050896;signaling#GO:0023052;T cell receptor signaling pathway#GO:0050852;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of cytokine production#GO:0001817;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of response to stimulus#GO:0048584;immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007;regulation of immune response#GO:0050776;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;immune response-activating cell surface receptor signaling pathway#GO:0002429 membrane#GO:0016020;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;plasma membrane#GO:0005886 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=26408|UniProtKB=Q96NL3 Q96NL3 ZNF599 PTHR24381:SF20 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 599 binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=43653|UniProtKB=O95073 O95073 FSBP PTHR15386:SF0 FIBRINOGEN SILENCER-BINDING PROTEIN FIBRINOGEN SILENCER-BINDING PROTEIN membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=2310|UniProtKB=Q6PUV4 Q6PUV4 CPLX2 PTHR16705:SF9 COMPLEXIN COMPLEXIN-2 SNARE binding#GO:0000149;binding#GO:0005488;protein binding#GO:0005515 regulation of organelle organization#GO:0033043;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;signaling#GO:0023052;export from cell#GO:0140352;regulation of cellular component organization#GO:0051128;regulation of signaling#GO:0023051;secretion by cell#GO:0032940;cellular localization#GO:0051641;cellular process#GO:0009987;synaptic vesicle exocytosis#GO:0016079;establishment of localization in cell#GO:0051649;synaptic signaling#GO:0099536;neurotransmitter transport#GO:0006836;regulation of trans-synaptic signaling#GO:0099177;vesicle-mediated transport#GO:0016192;regulated exocytosis#GO:0045055;regulation of localization#GO:0032879;regulation of transport#GO:0051049;exocytosis#GO:0006887;vesicle-mediated transport in synapse#GO:0099003;chemical synaptic transmission#GO:0007268;signal release from synapse#GO:0099643;regulation of cell communication#GO:0010646;modulation of chemical synaptic transmission#GO:0050804;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;trans-synaptic signaling#GO:0099537;signal release#GO:0023061;secretion#GO:0046903;cell communication#GO:0007154;localization#GO:0051179;neurotransmitter secretion#GO:0007269;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;synaptic vesicle cycle#GO:0099504;transport#GO:0006810;establishment of localization#GO:0051234 cell junction#GO:0030054;axon terminus#GO:0043679;membrane#GO:0016020;neuron projection#GO:0043005;presynapse#GO:0098793;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;axon#GO:0030424;intracellular anatomical structure#GO:0005622;membrane protein complex#GO:0098796;synapse#GO:0045202;cellular anatomical structure#GO:0110165;SNARE complex#GO:0031201;terminal bouton#GO:0043195;distal axon#GO:0150034;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;neuron projection terminus#GO:0044306 HUMAN|HGNC=44480|UniProtKB=K9M1U5 K9M1U5 IFNL4 PTHR31943:SF17 INTERLEUKIN-28 AND 29 INTERFERON LAMBDA-4 signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;signaling receptor regulator activity#GO:0030545;cytokine activity#GO:0005125;receptor ligand activity#GO:0048018 response to stimulus#GO:0050896;defense response to other organism#GO:0098542;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to other organism#GO:0051707;response to biotic stimulus#GO:0009607;defense response to virus#GO:0051607;response to stress#GO:0006950;immune response#GO:0006955;defense response to symbiont#GO:0140546;response to virus#GO:0009615;innate immune response#GO:0045087;response to external stimulus#GO:0009605;defense response#GO:0006952;immune system process#GO:0002376 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 cytokine#PC00083;interleukin superfamily#PC00128;intercellular signal molecule#PC00207 HUMAN|HGNC=99|UniProtKB=Q16515 Q16515 ASIC2 PTHR11690:SF307 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED ACID-SENSING ION CHANNEL 2 sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;ligand-gated monoatomic cation channel activity#GO:0099094;transporter activity#GO:0005215;sodium channel activity#GO:0005272;transmembrane transporter activity#GO:0022857;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;gated channel activity#GO:0022836;ligand-gated monoatomic ion channel activity#GO:0015276 transport#GO:0006810;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 ion channel#PC00133;transporter#PC00227 HUMAN|HGNC=9104|UniProtKB=O15031 O15031 PLXNB2 PTHR22625:SF9 PLEXIN PLEXIN-B2 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 regulation of anatomical structure morphogenesis#GO:0022603;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;regulation of axonogenesis#GO:0050770;cell surface receptor signaling pathway#GO:0007166;positive regulation of cell differentiation#GO:0045597;cellular component assembly#GO:0022607;nervous system development#GO:0007399;regulation of multicellular organismal process#GO:0051239;positive regulation of cell development#GO:0010720;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;regulation of neuron projection development#GO:0010975;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;regulation of biological quality#GO:0065008;positive regulation of axonogenesis#GO:0050772;animal gross anatomical part developmental process#GO:0160108;positive regulation of cellular component organization#GO:0051130;synapse assembly#GO:0007416;positive regulation of nervous system development#GO:0051962;response to stimulus#GO:0050896;regulation of cellular component organization#GO:0051128;signaling#GO:0023052;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;cell junction assembly#GO:0034329;regulation of multicellular organismal development#GO:2000026;positive regulation of multicellular organismal process#GO:0051240;regulation of cell shape#GO:0008360;regulation of biological process#GO:0050789;regulation of plasma membrane bounded cell projection organization#GO:0120035;negative regulation of cellular process#GO:0048523;regulation of cell projection organization#GO:0031344;regulation of cell differentiation#GO:0045595;positive regulation of developmental process#GO:0051094;regulation of cell migration#GO:0030334;developmental process#GO:0032502;multicellular organismal process#GO:0032501;regulation of cell adhesion#GO:0030155;negative regulation of cell adhesion#GO:0007162;regulation of locomotion#GO:0040012;biological regulation#GO:0065007;regulation of cell development#GO:0060284;positive regulation of cellular process#GO:0048522;anatomical structure development#GO:0048856;regulation of nervous system development#GO:0051960;regulation of cell motility#GO:2000145;cell communication#GO:0007154;system development#GO:0048731;positive regulation of cell projection organization#GO:0031346;synapse organization#GO:0050808;regulation of cellular process#GO:0050794;cell junction organization#GO:0034330;positive regulation of neurogenesis#GO:0050769;regulation of developmental process#GO:0050793;regulation of neurogenesis#GO:0050767;cellular response to stimulus#GO:0051716 cell periphery#GO:0071944;signaling receptor complex#GO:0043235;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 transmembrane signal receptor#PC00197 HUMAN|HGNC=21350|UniProtKB=O00330 O00330 PDHX PTHR23151:SF92 DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED PYRUVATE DEHYDROGENASE PROTEIN X COMPONENT, MITOCHONDRIAL organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;oxidoreductase complex#GO:1990204;mitochondrion#GO:0005739;acetyltransferase complex#GO:1902493;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex#GO:1990234 acetyltransferase#PC00038;transferase#PC00220 HUMAN|HGNC=1690|UniProtKB=O43866 O43866 CD5L PTHR48071:SF8 SRCR DOMAIN-CONTAINING PROTEIN CD5 ANTIGEN-LIKE regulation of immune response#GO:0050776;regulation of biological process#GO:0050789;regulation of response to stimulus#GO:0048583;regulation of immune system process#GO:0002682;regulation of immune effector process#GO:0002697;biological regulation#GO:0065007 HUMAN|HGNC=2360|UniProtKB=P50238 P50238 CRIP1 PTHR46074:SF3 CYSTEINE-RICH PROTEIN CRIP FAMILY MEMBER CYSTEINE-RICH PROTEIN 1 small molecule binding#GO:0036094;binding#GO:0005488;zinc ion binding#GO:0008270;ion binding#GO:0043167;transition metal ion binding#GO:0046914;metal ion binding#GO:0046872;cation binding#GO:0043169 signaling#GO:0023052;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;response to stimulus#GO:0050896;apoptotic process#GO:0006915;cell death#GO:0008219;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;programmed cell death#GO:0012501;intracellular signal transduction#GO:0035556;intrinsic apoptotic signaling pathway#GO:0097193;cell communication#GO:0007154;cellular response to stress#GO:0033554;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;response to stress#GO:0006950;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;intrinsic apoptotic signaling pathway in response to DNA damage#GO:0008630;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;apoptotic signaling pathway#GO:0097190;DNA damage response#GO:0006974 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=8574|UniProtKB=P43034 P43034 PAFAH1B1 PTHR44129:SF16 WD REPEAT-CONTAINING PROTEIN POP1 PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE IB SUBUNIT BETA microtubule binding#GO:0008017;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;protein binding#GO:0005515 transport#GO:0006810;developmental process#GO:0032502;intracellular transport#GO:0046907;neurogenesis#GO:0022008;microtubule-based process#GO:0007017;transport along microtubule#GO:0010970;cellular developmental process#GO:0048869;establishment of localization#GO:0051234;multicellular organism development#GO:0007275;neuron migration#GO:0001764;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;axo-dendritic transport#GO:0008088;nervous system development#GO:0007399;cell migration#GO:0016477;multicellular organismal process#GO:0032501;cytoskeleton-dependent intracellular transport#GO:0030705;retrograde axonal transport#GO:0008090;generation of neurons#GO:0048699;microtubule-based transport#GO:0099111;animal gross anatomical part developmental process#GO:0160108;axonal transport#GO:0098930;system development#GO:0048731;anatomical structure development#GO:0048856;cellular localization#GO:0051641;localization#GO:0051179;microtubule-based movement#GO:0007018;cell motility#GO:0048870;cell differentiation#GO:0030154 intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;kinetochore#GO:0000776;membraneless organelle#GO:0043228;condensed chromosome#GO:0000793;chromosome, centromeric region#GO:0000775;cytoskeleton#GO:0005856;centrosome#GO:0005813;microtubule organizing center#GO:0005815;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;condensed chromosome, centromeric region#GO:0000779;microtubule cytoskeleton#GO:0015630;nucleus#GO:0005634 HUMAN|HGNC=12643|UniProtKB=P63027 P63027 VAMP2 PTHR45701:SF5 SYNAPTOBREVIN FAMILY MEMBER VESICLE-ASSOCIATED MEMBRANE PROTEIN 2 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;SNARE binding#GO:0000149;binding#GO:0005488;syntaxin binding#GO:0019905;SNAP receptor activity#GO:0005484;protein binding#GO:0005515 organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;membrane fusion#GO:0061025;cellular process#GO:0009987;organelle fusion#GO:0048284;cellular component assembly#GO:0022607;vesicle-mediated transport#GO:0016192;membrane organization#GO:0061024;organelle membrane fusion#GO:0090174;transport#GO:0006810;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;vesicle organization#GO:0016050;protein-containing complex organization#GO:0043933;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;vesicle fusion#GO:0006906;localization#GO:0051179 intracellular anatomical structure#GO:0005622;cell periphery#GO:0071944;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;SNARE complex#GO:0031201;protein-containing complex#GO:0032991 membrane traffic protein#PC00150 5HT2 type receptor mediated signaling pathway#P04374>SNARE Complex#P04415;Opioid proenkephalin pathway#P05915>SNARE Complex#P05986;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>SNARE Complex#P01079;Alpha adrenergic receptor signaling pathway#P00002>SNARE#P00074;5HT4 type receptor mediated signaling pathway#P04376>SNARE Complex#P04428;Circadian clock system#P00015>per#G01499;Adrenaline and noradrenaline biosynthesis#P00001>SNARE#P00072;Beta1 adrenergic receptor signaling pathway#P04377>SNARE Complex#P04435;5HT1 type receptor mediated signaling pathway#P04373>SNARE Complex#P04405;Synaptic vesicle trafficking#P05734>Synaptobrevin#P05779;Opioid prodynorphin pathway#P05916>SNARE Complex#P05996;Beta2 adrenergic receptor signaling pathway#P04378>SNARE Complex#P04442;Dopamine receptor mediated signaling pathway#P05912>SNARE Complex#P05956;Beta3 adrenergic receptor signaling pathway#P04379>SNARE Complex#P04447;5HT3 type receptor mediated signaling pathway#P04375>SNARE Complex#P04423;Circadian clock system#P00015>Per#P00504;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>SNARE Complex#P01066;Opioid proopiomelanocortin pathway#P05917>SNARE Complex#P06005;Metabotropic glutamate receptor group II pathway#P00040>SNARE Complex#P01049;Nicotinic acetylcholine receptor signaling pathway#P00044>SNARE Complex#P01091;Cortocotropin releasing factor receptor signaling pathway#P04380>SNARE Complex#P04457;Ionotropic glutamate receptor pathway#P00037>SNARE Complex#P01013;Metabotropic glutamate receptor group III pathway#P00039>SNARE Complex#P01042;Thyrotropin-releasing hormone receptor signaling pathway#P04394>SNARE Complex#P04582;Oxytocin receptor mediated signaling pathway#P04391>SNARE Complex#P04532;Circadian clock system#P00015>per#G01503 HUMAN|HGNC=2937|UniProtKB=Q9Y485 Q9Y485 DMXL1 PTHR13950:SF12 RABCONNECTIN-RELATED DMX-LIKE PROTEIN 1 cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;localization#GO:0051179;cellular localization#GO:0051641;cellular component biogenesis#GO:0044085;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;early endosome to late endosome transport#GO:0045022;cellular component assembly#GO:0022607;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;transport#GO:0006810;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;endosomal transport#GO:0016197;protein-containing complex organization#GO:0043933 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=23355|UniProtKB=Q9NTK1 Q9NTK1 DEPP1 PTHR15426:SF6 PROTEIN DEPP1 PROTEIN DEPP1 regulation of biological process#GO:0050789;regulation of autophagy#GO:0010506;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of catabolic process#GO:0009894;regulation of cellular process#GO:0050794 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739 HUMAN|HGNC=2917|UniProtKB=Q92988 Q92988 DLX4 PTHR24327:SF21 HOMEOBOX PROTEIN HOMEOBOX PROTEIN DLX-4 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;embryo development#GO:0009790;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;chordate embryonic development#GO:0043009;animal gross anatomical part developmental process#GO:0160108;embryo development ending in birth or egg hatching#GO:0009792;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;skeletal system development#GO:0001501;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154 gene-specific transcriptional regulator#PC00264;helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=26542|UniProtKB=Q5T2T1 Q5T2T1 MPP7 PTHR23122:SF39 MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK MAGUK P55 SUBFAMILY MEMBER 7 macromolecule localization#GO:0033036;protein localization to cell junction#GO:1902414;localization#GO:0051179;intracellular protein localization#GO:0008104 cell junction#GO:0030054;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;anchoring junction#GO:0070161;membrane#GO:0016020;cell-cell junction#GO:0005911;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HUMAN|HGNC=31371|UniProtKB=Q6PRD1 Q6PRD1 GPR179 PTHR32546:SF7 G-PROTEIN COUPLED RECEPTOR 158-RELATED G PROTEIN-COUPLED RECEPTOR 179-RELATED G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=23336|UniProtKB=A8K2U0 A8K2U0 A2ML1 PTHR11412:SF182 MACROGLOBULIN / COMPLEMENT ALPHA-2-MACROGLOBULIN-LIKE PROTEIN 1 molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;peptidase regulator activity#GO:0061134;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866;enzyme inhibitor activity#GO:0004857 defense response#GO:0006952;response to stimulus#GO:0050896;inflammatory response#GO:0006954;response to stress#GO:0006950 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;extracellular protein-containing complex#GO:0140392;extracellular region#GO:0005576 protease inhibitor#PC00191 HUMAN|HGNC=11585|UniProtKB=O60907 O60907 TBL1X PTHR22846:SF52 WD40 REPEAT PROTEIN F-BOX-LIKE_WD REPEAT-CONTAINING PROTEIN TBL1X double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;binding#GO:0005488;nucleic acid binding#GO:0003676;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714 negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892 transcription repressor complex#GO:0017053;transcription regulator complex#GO:0005667;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;histone deacetylase complex#GO:0000118;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226 Wnt signaling pathway#P00057>Ebi#P01453 HUMAN|HGNC=16698|UniProtKB=Q96PQ0 Q96PQ0 SORCS2 PTHR12106:SF9 SORTILIN RELATED VPS10 DOMAIN-CONTAINING RECEPTOR SORCS2 transport#GO:0006810;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193;localization#GO:0051179;vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;post-Golgi vesicle-mediated transport#GO:0006892 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794 membrane traffic protein#PC00150 HUMAN|HGNC=20193|UniProtKB=A2PYH4 A2PYH4 HFM1 PTHR47961:SF19 DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED ATP-DEPENDENT DNA HELICASE HFM1-RELATED DNA metabolism protein#PC00009 HUMAN|HGNC=10773|UniProtKB=P31947 P31947 SFN PTHR18860:SF14 14-3-3 PROTEIN 14-3-3 PROTEIN SIGMA protein binding#GO:0005515;binding#GO:0005488;kinase binding#GO:0019900;protein kinase binding#GO:0019901;enzyme binding#GO:0019899 scaffold/adaptor protein#PC00226 Parkinson disease#P00049>14-3-3#P01238;p53 pathway#P00059>14-3-3#P04628;p53 pathway#P00059>14-3-3#G01576;EGF receptor signaling pathway#P00018>14-3-3#P00539;FGF signaling pathway#P00021>14-3-3#P00624 HUMAN|HGNC=31971|UniProtKB=O60810 O60810 PRAMEF4 PTHR14224:SF112 SIMILAR TO PREFERENTIALLY EXPRESSED ANTIGEN IN MELANOMA-LIKE 3 PRAME FAMILY MEMBER 11-RELATED ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498 cullin-RING ubiquitin ligase complex#GO:0031461;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;transferase complex#GO:1990234;Cul2-RING ubiquitin ligase complex#GO:0031462 HUMAN|HGNC=26308|UniProtKB=Q6ZTQ4 Q6ZTQ4 CDHR3 PTHR24027:SF439 CADHERIN-23 CADHERIN-RELATED FAMILY MEMBER 3 cell adhesion molecule binding#GO:0050839;binding#GO:0005488;beta-catenin binding#GO:0008013;protein binding#GO:0005515 cell morphogenesis#GO:0000902;cell junction organization#GO:0034330;cell motility#GO:0048870;adherens junction organization#GO:0034332;cell junction assembly#GO:0034329;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;cell adhesion#GO:0007155;cellular component assembly#GO:0022607;cell migration#GO:0016477;cellular component biogenesis#GO:0044085;cell-cell adhesion#GO:0098609;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;cell-cell junction organization#GO:0045216;developmental process#GO:0032502;cell-cell junction assembly#GO:0007043 adherens junction#GO:0005912;anchoring junction#GO:0070161;cell junction#GO:0030054;extrinsic component of membrane#GO:0019898;extrinsic component of plasma membrane#GO:0019897;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane protein complex#GO:0098796;cell-cell junction#GO:0005911;membrane#GO:0016020 cadherin#PC00057;cell adhesion molecule#PC00069 HUMAN|HGNC=7142|UniProtKB=P49006 P49006 MARCKSL1 PTHR14353:SF8 MYRISTOYLATED ALANINE-RICH C-KINASE SUBSTRATE MARCKS MARCKS-RELATED PROTEIN protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;actin binding#GO:0003779;actin filament binding#GO:0051015;cytoskeletal protein binding#GO:0008092 anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;actin filament-based process#GO:0030029;central nervous system development#GO:0007417;actin cytoskeleton organization#GO:0030036;cellular component organization#GO:0016043;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;actin filament organization#GO:0007015;developmental process#GO:0032502;multicellular organismal process#GO:0032501;cytoskeleton organization#GO:0007010;nervous system development#GO:0007399;organelle organization#GO:0006996;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=14980|UniProtKB=P57768 P57768 SNX16 PTHR22999:SF43 PX SERINE/THREONINE KINASE PXK SORTING NEXIN-16 small molecule binding#GO:0036094;anion binding#GO:0043168;phosphatidylinositol binding#GO:0035091;binding#GO:0005488;ion binding#GO:0043167 intracellular transport#GO:0046907;endosome to lysosome transport#GO:0008333;lysosomal transport#GO:0007041;metabolic process#GO:0008152;transport#GO:0006810;vacuolar transport#GO:0007034;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;macromolecule metabolic process#GO:0043170;endosomal transport#GO:0016197;cellular process#GO:0009987;early endosome to late endosome transport#GO:0045022;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192 intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;late endosome#GO:0005770;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=1683|UniProtKB=P09326 P09326 CD48 PTHR12080:SF134 SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE CD48 ANTIGEN molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 multicellular organismal process#GO:0032501;lymphocyte activation#GO:0046649;biological regulation#GO:0065007;cellular process#GO:0009987;immune response#GO:0006955;signal transduction#GO:0007165;cell communication#GO:0007154;immune system process#GO:0002376;cell activation#GO:0001775;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;T cell activation#GO:0042110;leukocyte activation#GO:0045321;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=15007|UniProtKB=Q8NGZ5 Q8NGZ5 OR2G2 PTHR26453:SF132 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2G2 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;sensory perception#GO:0007600;nervous system process#GO:0050877;system process#GO:0003008;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;detection of chemical stimulus#GO:0009593;response to stimulus#GO:0050896;response to chemical#GO:0042221;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=26978|UniProtKB=A8K830 A8K830 POU2AF3 PTHR36689:SF1 COLORECTAL CANCER-ASSOCIATED PROTEIN 2 POU CLASS 2 HOMEOBOX ASSOCIATING FACTOR 3 HUMAN|HGNC=6077|UniProtKB=P32019 P32019 INPP5B PTHR11200:SF307 INOSITOL 5-PHOSPHATASE TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578 cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;neuron projection#GO:0043005;membrane#GO:0016020;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622 phosphatase#PC00181;hydrolase#PC00121 HUMAN|HGNC=14325|UniProtKB=Q9BXJ5 Q9BXJ5 C1QTNF2 PTHR15427:SF28 EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER COMPLEMENT C1Q TUMOR NECROSIS FACTOR-RELATED PROTEIN 2 molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545 regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;regulation of biological process#GO:0050789;regulation of cell communication#GO:0010646;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cellular process#GO:0050794 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=5554|UniProtKB=P01743 P01743 IGHV1-46 PTHR23266:SF410 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 1-46 antigen binding#GO:0003823;binding#GO:0005488 immune response#GO:0006955;response to stimulus#GO:0050896;adaptive immune response#GO:0002250;immune system process#GO:0002376;immune effector process#GO:0002252;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;immunoglobulin mediated immune response#GO:0016064;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=26040|UniProtKB=Q8N5Y8 Q8N5Y8 PARP16 PTHR21328:SF2 POLY ADP-RIBOSE POLYMERASE FAMILY, MEMBER PARP PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP16 protein serine/threonine kinase activator activity#GO:0043539;enzyme activator activity#GO:0008047;protein kinase activator activity#GO:0030295;protein kinase regulator activity#GO:0019887;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;binding#GO:0005488;kinase binding#GO:0019900;kinase activator activity#GO:0019209;enzyme binding#GO:0019899;enzyme regulator activity#GO:0030234;protein binding#GO:0005515;molecular function activator activity#GO:0140677 signaling#GO:0023052;response to topologically incorrect protein#GO:0035966;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;response to unfolded protein#GO:0006986;cellular response to topologically incorrect protein#GO:0035967;cellular response to stress#GO:0033554;cellular response to unfolded protein#GO:0034620;response to endoplasmic reticulum stress#GO:0034976;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;response to stress#GO:0006950;endoplasmic reticulum unfolded protein response#GO:0030968 organelle envelope#GO:0031967;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;endoplasmic reticulum tubular network#GO:0071782;nucleus#GO:0005634;endomembrane system#GO:0012505;nuclear envelope#GO:0005635;cytoplasm#GO:0005737;endoplasmic reticulum#GO:0005783 HUMAN|HGNC=11466|UniProtKB=O75486 O75486 SUPT3H PTHR11380:SF16 TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED TRANSCRIPTION INITIATION PROTEIN SPT3 HOMOLOG transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;transcription coactivator activity#GO:0003713 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;transcription by RNA polymerase II#GO:0006366;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170 general transcription factor#PC00259 HUMAN|HGNC=6215|UniProtKB=Q15046 Q15046 KARS1 PTHR42918:SF16 LYSYL-TRNA SYNTHETASE LYSINE--TRNA LIGASE ligase activity#GO:0016874;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a nucleic acid#GO:0140640;nucleotidyltransferase activity#GO:0016779;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on RNA#GO:0140098;adenylyltransferase activity#GO:0070566;binding#GO:0005488;nucleic acid binding#GO:0003676;tRNA binding#GO:0000049;catalytic activity, acting on a tRNA#GO:0140101;RNA binding#GO:0003723 immune system process#GO:0002376;nucleotide biosynthetic process#GO:0009165;cell activation involved in immune response#GO:0002263;nucleotide metabolic process#GO:0009117;RNA metabolic process#GO:0016070;regulation of biological process#GO:0050789;positive regulation of multicellular organismal process#GO:0051240;regulation of cell activation#GO:0050865;regulation of leukocyte activation#GO:0002694;phosphorus metabolic process#GO:0006793;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;protein biosynthetic process#GO:0160307;leukocyte activation involved in immune response#GO:0002366;immune effector process#GO:0002252;positive regulation of leukocyte activation#GO:0002696;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;nucleobase-containing small molecule metabolic process#GO:0055086;tRNA aminoacylation for protein translation#GO:0006418;regulation of macrophage activation#GO:0043030;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of immune system process#GO:0002684;regulation of multicellular organismal process#GO:0051239;myeloid leukocyte activation#GO:0002274;gene expression#GO:0010467;translation#GO:0006412;cell activation#GO:0001775;organophosphate biosynthetic process#GO:0090407;protein metabolic process#GO:0019538;leukocyte activation#GO:0045321;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;nucleoside phosphate metabolic process#GO:0006753;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;nucleoside phosphate biosynthetic process#GO:1901293;macromolecule metabolic process#GO:0043170;amino acid activation#GO:0043038;immune response#GO:0006955;positive regulation of cellular process#GO:0048522;macromolecule biosynthetic process#GO:0009059;organophosphate metabolic process#GO:0019637;tRNA aminoacylation#GO:0043039;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;biological regulation#GO:0065007;positive regulation of cell activation#GO:0050867;amino acid metabolic process#GO:0006520;multicellular organismal process#GO:0032501 catalytic complex#GO:1902494;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 HUMAN|HGNC=32007|UniProtKB=Q8IWB4 Q8IWB4 SPATA31A7 PTHR21859:SF55 ACROSOME-SPECIFIC PROTEIN SPERMATOGENESIS-ASSOCIATED PROTEIN 31A1-RELATED HUMAN|HGNC=10875|UniProtKB=O43699 O43699 SIGLEC6 PTHR12035:SF129 SIALIC ACID BINDING IMMUNOGLOBULIN-LIKE LECTIN SIALIC ACID-BINDING IG-LIKE LECTIN 6 ion binding#GO:0043167;carbohydrate derivative binding#GO:0097367;small molecule binding#GO:0036094;anion binding#GO:0043168;carboxylic acid binding#GO:0031406;binding#GO:0005488;organic acid binding#GO:0043177 cellular process#GO:0009987;cell adhesion#GO:0007155 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 immunoglobulin superfamily cell adhesion molecule#PC00125;cell adhesion molecule#PC00069 HUMAN|HGNC=20531|UniProtKB=P60328 P60328 KRTAP12-3 PTHR23262:SF148 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 12-3 structural protein#PC00211 HUMAN|HGNC=33446|UniProtKB=A6NHG4 A6NHG4 DDTL PTHR11954:SF39 D-DOPACHROME DECARBOXYLASE D-DOPACHROME DECARBOXYLASE-LIKE PROTEIN-RELATED catalytic activity#GO:0003824;intramolecular oxidoreductase activity#GO:0016860;isomerase activity#GO:0016853 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 decarboxylase#PC00089;lyase#PC00144;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=2750|UniProtKB=Q08211 Q08211 DHX9 PTHR18934:SF119 ATP-DEPENDENT RNA HELICASE ATP-DEPENDENT RNA HELICASE A catalytic activity#GO:0003824;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;macromolecular conformation isomerase activity#GO:0120543;helicase activity#GO:0004386;isomerase activity#GO:0016853;nucleic acid binding#GO:0003676;binding#GO:0005488;ATP-dependent activity#GO:0140657;RNA binding#GO:0003723 intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;membraneless organelle#GO:0043228;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730 RNA metabolism protein#PC00031;RNA helicase#PC00032 HUMAN|HGNC=19269|UniProtKB=Q8TAA1 Q8TAA1 RNASE11 PTHR11437:SF22 RIBONUCLEASE INACTIVE RIBONUCLEASE 11-RELATED catalytic activity, acting on RNA#GO:0140098;RNA nuclease activity#GO:0004540;nuclease activity#GO:0004518;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640 response to other organism#GO:0051707;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;defense response to Gram-positive bacterium#GO:0050830;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;defense response#GO:0006952;response to external stimulus#GO:0009605;defense response to bacterium#GO:0042742;response to bacterium#GO:0009617 RNA metabolism protein#PC00031;endoribonuclease#PC00094 HUMAN|HGNC=27538|UniProtKB=P0C7N1 P0C7N1 OR8U8 PTHR48018:SF91 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 8U1-RELATED olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;sensory perception of smell#GO:0007608;regulation of cellular process#GO:0050794;signaling#GO:0023052;G protein-coupled receptor signaling pathway#GO:0007186;sensory perception#GO:0007600;nervous system process#GO:0050877;cell communication#GO:0007154;signal transduction#GO:0007165;cellular process#GO:0009987;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=19266|UniProtKB=Q6XYQ8 Q6XYQ8 SYT10 PTHR10024:SF46 SYNAPTOTAGMIN SYNAPTOTAGMIN-10 SNARE binding#GO:0000149;phospholipid binding#GO:0005543;binding#GO:0005488;protein binding#GO:0005515;molecular function regulator activity#GO:0098772;lipid binding#GO:0008289;molecular sensor activity#GO:0140299 establishment of localization#GO:0051234;regulation of transport#GO:0051049;regulation of localization#GO:0032879;transport#GO:0006810;vesicle-mediated transport#GO:0016192;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;synaptic signaling#GO:0099536;cellular process#GO:0009987;localization#GO:0051179;regulation of secretion#GO:0051046;cell communication#GO:0007154;regulation of secretion by cell#GO:1903530;regulation of exocytosis#GO:0017157;trans-synaptic signaling#GO:0099537;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;signaling#GO:0023052;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;transport vesicle#GO:0030133;endomembrane system#GO:0012505;plasma membrane#GO:0005886;cytoplasm#GO:0005737;secretory vesicle#GO:0099503;membrane#GO:0016020;cell periphery#GO:0071944 membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=4316|UniProtKB=Q92896 Q92896 GLG1 PTHR11884:SF1 SELECTIN LIGAND RELATED GOLGI APPARATUS PROTEIN 1 binding#GO:0005488;fibroblast growth factor binding#GO:0017134;protein binding#GO:0005515;growth factor binding#GO:0019838 regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;regulation of cell communication#GO:0010646;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cellular response to growth factor stimulus#GO:0090287;regulation of cellular process#GO:0050794;regulation of transforming growth factor beta receptor signaling pathway#GO:0017015;regulation of biological process#GO:0050789;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092 intracellular organelle#GO:0043229;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 HUMAN|HGNC=15633|UniProtKB=Q9NR96 Q9NR96 TLR9 PTHR47410:SF3 TOLL-LIKE RECEPTOR 7-RELATED TOLL-LIKE RECEPTOR 9 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;pattern recognition receptor activity#GO:0038187 cellular response to stimulus#GO:0051716;innate immune response-activating signaling pathway#GO:0002758;regulation of response to biotic stimulus#GO:0002831;response to external biotic stimulus#GO:0043207;regulation of immune system process#GO:0002682;positive regulation of cytokine production#GO:0001819;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of defense response#GO:0031347;regulation of immune response#GO:0050776;intracellular signal transduction#GO:0035556;response to virus#GO:0009615;cell communication#GO:0007154;positive regulation of biosynthetic process#GO:0009891;positive regulation of innate immune response#GO:0045089;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cytokine production#GO:0001817;activation of innate immune response#GO:0002218;response to other organism#GO:0051707;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;canonical NF-kappaB signal transduction#GO:0007249;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;positive regulation of defense response#GO:0031349;regulation of response to stress#GO:0080134;defense response#GO:0006952;regulation of gene expression#GO:0010468;pattern recognition receptor signaling pathway#GO:0002221;response to external stimulus#GO:0009605;positive regulation of response to biotic stimulus#GO:0002833;positive regulation of gene expression#GO:0010628;regulation of biosynthetic process#GO:0009889;regulation of innate immune response#GO:0045088;positive regulation of multicellular organismal process#GO:0051240;immune response-regulating signaling pathway#GO:0002764;regulation of biological process#GO:0050789;defense response to virus#GO:0051607;toll-like receptor signaling pathway#GO:0002224;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;immune system process#GO:0002376;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;cellular process#GO:0009987;activation of immune response#GO:0002253;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of immune system process#GO:0002684;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;intracellular signaling cassette#GO:0141124;regulation of multicellular organismal process#GO:0051239;regulation of response to external stimulus#GO:0032101;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of response to external stimulus#GO:0032103;immune response-activating signaling pathway#GO:0002757 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 Toll receptor signaling pathway#P00054>TLR#P01346 HUMAN|HGNC=29477|UniProtKB=O15243 O15243 LEPROT PTHR12050:SF3 LEPTIN RECEPTOR-RELATED LEPTIN RECEPTOR GENE-RELATED PROTEIN cytosolic transport#GO:0016482;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;retrograde transport, endosome to Golgi#GO:0042147;endosomal transport#GO:0016197;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;transport#GO:0006810;intracellular transport#GO:0046907 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endosome membrane#GO:0010008;endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;membrane#GO:0016020;vesicle membrane#GO:0012506;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588 transmembrane signal receptor#PC00197 HUMAN|HGNC=16970|UniProtKB=O43559 O43559 FRS3 PTHR21258:SF39 DOCKING PROTEIN RELATED FIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 3 protein binding#GO:0005515;signaling adaptor activity#GO:0035591;protein-macromolecule adaptor activity#GO:0030674;kinase binding#GO:0019900;binding#GO:0005488;signaling receptor binding#GO:0005102;protein tyrosine kinase binding#GO:1990782;transmembrane receptor protein tyrosine kinase adaptor activity#GO:0005068;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;fibroblast growth factor receptor binding#GO:0005104;growth factor receptor binding#GO:0070851;molecular adaptor activity#GO:0060090;signaling receptor complex adaptor activity#GO:0030159;receptor tyrosine kinase binding#GO:0030971 cellular response to growth factor stimulus#GO:0071363;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;signaling#GO:0023052;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;response to growth factor#GO:0070848;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to endogenous stimulus#GO:0009719;cell surface receptor signaling pathway#GO:0007166;response to fibroblast growth factor#GO:0071774;biological regulation#GO:0065007;fibroblast growth factor receptor signaling pathway#GO:0008543;signal transduction#GO:0007165;cellular response to fibroblast growth factor stimulus#GO:0044344;cellular process#GO:0009987 scaffold/adaptor protein#PC00226 Angiogenesis#P00005>FRS-2#P00240;FGF signaling pathway#P00021>FRS2#P00635 HUMAN|HGNC=53435|UniProtKB=A0A1B0GVZ6 A0A1B0GVZ6 MBD3L2B PTHR12396:SF6 METHYL-CPG BINDING PROTEIN, MBD METHYL-CPG-BINDING DOMAIN PROTEIN 3-LIKE 2-RELATED negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;DNA methylation-dependent constitutive heterochromatin formation#GO:0006346;cellular component organization or biogenesis#GO:0071840;negative regulation of gene expression, epigenetic#GO:0045814;constitutive heterochromatin formation#GO:0140719;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;cellular component assembly#GO:0022607;heterochromatin organization#GO:0070828;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;regulation of DNA-templated transcription#GO:0006355;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;heterochromatin formation#GO:0031507;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;chromatin organization#GO:0006325;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;epigenetic regulation of gene expression#GO:0040029;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=15865|UniProtKB=Q2M2Z5 Q2M2Z5 KIZ PTHR16299:SF2 CENTROSOMAL PROTEIN KIZUNA CENTROSOMAL PROTEIN KIZUNA cytoskeleton organization#GO:0007010;cell cycle#GO:0007049;organelle organization#GO:0006996;cellular component organization#GO:0016043;cell cycle process#GO:0022402;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;spindle organization#GO:0007051;microtubule cytoskeleton organization#GO:0000226;microtubule-based process#GO:0007017 microtubule cytoskeleton#GO:0015630;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;centrosome#GO:0005813;microtubule organizing center#GO:0005815;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=16508|UniProtKB=Q96QF0 Q96QF0 RAB3IP PTHR14430:SF2 RABIN3-RELATED RAB-3A-INTERACTING PROTEIN guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 protein-binding activity modulator#PC00095;G-protein modulator#PC00022;guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=8744|UniProtKB=P16519 P16519 PCSK2 PTHR42884:SF13 PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED NEUROENDOCRINE CONVERTASE 2 catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171 peptide hormone processing#GO:0016486;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein processing#GO:0016485;gene expression#GO:0010467;protein maturation#GO:0051604;hormone metabolic process#GO:0042445;biosynthetic process#GO:0009058;biological regulation#GO:0065007;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;regulation of hormone levels#GO:0010817;proteolysis#GO:0006508;protein metabolic process#GO:0019538;signaling receptor ligand precursor processing#GO:0140448;regulation of biological quality#GO:0065008 endomembrane system#GO:0012505;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;neuron projection#GO:0043005;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;extracellular region#GO:0005576;intracellular organelle#GO:0043229 serine protease#PC00203 Alzheimer disease-amyloid secretase pathway#P00003>Furin#P00105;Alzheimer disease-presenilin pathway#P00004>Furin#P00157 HUMAN|HGNC=9901|UniProtKB=Q9BWF3 Q9BWF3 RBM4 PTHR23147:SF233 SERINE/ARGININE RICH SPLICING FACTOR RNA-BINDING PROTEIN 4 circadian rhythm#GO:0007623;rhythmic process#GO:0048511 membraneless organelle#GO:0043228;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;nuclear body#GO:0016604;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear speck#GO:0016607 RNA splicing factor#PC00148;RNA metabolism protein#PC00031;RNA processing factor#PC00147 HUMAN|HGNC=273|UniProtKB=Q9Y6F1 Q9Y6F1 PARP3 PTHR10459:SF66 DNA LIGASE PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP3 transferase activity#GO:0016740;catalytic activity#GO:0003824;NAD+ poly-ADP-ribosyltransferase activity#GO:0003950;pentosyltransferase activity#GO:0016763;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757 nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;DNA damage response#GO:0006974;cellular response to stress#GO:0033554;macromolecule metabolic process#GO:0043170;double-strand break repair#GO:0006302 site of double-strand break#GO:0035861;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228;organelle lumen#GO:0043233;chromosome#GO:0005694;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;site of DNA damage#GO:0090734;intracellular anatomical structure#GO:0005622 DNA metabolism protein#PC00009 FAS signaling pathway#P00020>PARP#P00600 HUMAN|HGNC=2584|UniProtKB=Q9NQC7 Q9NQC7 CYLD PTHR11830:SF15 40S RIBOSOMAL PROTEIN S3A UBIQUITIN CARBOXYL-TERMINAL HYDROLASE CYLD deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;structural constituent of ribosome#GO:0003735;cysteine-type deubiquitinase activity#GO:0004843;structural molecule activity#GO:0005198;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096 regulation of programmed cell death#GO:0043067;programmed cell death#GO:0012501;protein modification process#GO:0036211;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;cell death#GO:0008219;regulation of intrinsic apoptotic signaling pathway#GO:2001242;regulation of cellular process#GO:0050794;protein biosynthetic process#GO:0160307;regulation of cell cycle#GO:0051726;regulation of cell communication#GO:0010646;protein modification by small protein conjugation or removal#GO:0070647;regulation of intracellular signal transduction#GO:1902531;translation#GO:0006412;regulation of signaling#GO:0023051;regulation of apoptotic signaling pathway#GO:2001233;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;necroptotic process#GO:0070266;regulation of mitotic cell cycle#GO:0007346;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;biosynthetic process#GO:0009058;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;post-translational protein modification#GO:0043687;metabolic process#GO:0008152;regulation of apoptotic process#GO:0042981;regulation of response to stimulus#GO:0048583;macromolecule metabolic process#GO:0043170 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 translational protein#PC00263;ribosomal protein#PC00202 HUMAN|HGNC=29890|UniProtKB=Q86UT6 Q86UT6 NLRX1 PTHR24106:SF152 NACHT, LRR AND CARD DOMAINS-CONTAINING NLR FAMILY MEMBER X1 molecular function regulator activity#GO:0098772;molecular function inhibitor activity#GO:0140678 regulation of innate immune response#GO:0045088;negative regulation of cellular process#GO:0048523;regulation of response to stress#GO:0080134;regulation of response to stimulus#GO:0048583;regulation of response to external stimulus#GO:0032101;negative regulation of response to stimulus#GO:0048585;negative regulation of signal transduction#GO:0009968;biological regulation#GO:0065007;negative regulation of immune system process#GO:0002683;regulation of signal transduction#GO:0009966;regulation of canonical NF-kappaB signal transduction#GO:0043122;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;regulation of defense response#GO:0031347;regulation of immune response#GO:0050776;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;negative regulation of canonical NF-kappaB signal transduction#GO:0043124;regulation of cell communication#GO:0010646;regulation of response to biotic stimulus#GO:0002831;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789 mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HUMAN|HGNC=19748|UniProtKB=Q8N9L9 Q8N9L9 ACOT4 PTHR10824:SF6 ACYL-COENZYME A THIOESTERASE-RELATED PEROXISOMAL SUCCINYL-COENZYME A THIOESTERASE hydrolase activity#GO:0016787;catalytic activity#GO:0003824;deacylase activity#GO:0160215;acyl-CoA hydrolase activity#GO:0016289;fatty acyl-CoA hydrolase activity#GO:0047617;hydrolase activity, acting on ester bonds#GO:0016788;thiolester hydrolase activity#GO:0016790 nucleobase-containing compound metabolic process#GO:0006139;long-chain fatty acid metabolic process#GO:0001676;organophosphate metabolic process#GO:0019637;sulfur compound metabolic process#GO:0006790;cellular process#GO:0009987;nucleobase-containing small molecule metabolic process#GO:0055086;acyl-CoA metabolic process#GO:0006637;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;lipid metabolic process#GO:0006629;small molecule metabolic process#GO:0044281;very long-chain fatty acid metabolic process#GO:0000038;nucleoside phosphate metabolic process#GO:0006753;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521;oxoacid metabolic process#GO:0043436 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;microbody#GO:0042579;peroxisome#GO:0005777;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 esterase#PC00097 HUMAN|HGNC=12338|UniProtKB=Q9Y210 Q9Y210 TRPC6 PTHR10117:SF7 TRANSIENT RECEPTOR POTENTIAL CHANNEL SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 6 metal ion transmembrane transporter activity#GO:0046873;alcohol binding#GO:0043178;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;binding#GO:0005488;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;passive transmembrane transporter activity#GO:0022803;channel activity#GO:0015267;anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167 monoatomic ion homeostasis#GO:0050801;single fertilization#GO:0007338;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;establishment of localization#GO:0051234;intracellular calcium ion homeostasis#GO:0006874;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;calcium ion transport#GO:0006816;calcium ion transmembrane transport#GO:0070588;intracellular monoatomic ion homeostasis#GO:0006873;regulation of cytosolic calcium ion concentration#GO:0051480;homeostatic process#GO:0042592;metal ion transport#GO:0030001;fertilization#GO:0009566;reproductive process#GO:0022414;calcium ion homeostasis#GO:0055074;sexual reproduction#GO:0019953;inorganic ion homeostasis#GO:0098771;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811 cation channel complex#GO:0034703;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;cell periphery#GO:0071944;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165 ion channel#PC00133 Alzheimer disease-presenilin pathway#P00004>Capacitative calcium channels#P00124 HUMAN|HGNC=4416|UniProtKB=O15228 O15228 GNPAT PTHR12563:SF17 GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE DIHYDROXYACETONE PHOSPHATE ACYLTRANSFERASE acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740;acetyltransferase activity#GO:0016407;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 lipid metabolic process#GO:0006629;cellular process#GO:0009987;primary metabolic process#GO:0044238;metabolic process#GO:0008152;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610 peroxisomal membrane#GO:0005778;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;peroxisome#GO:0005777;microbody#GO:0042579;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 acyltransferase#PC00042;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=24573|UniProtKB=Q8TAT5 Q8TAT5 NEIL3 PTHR22993:SF10 FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE ENDONUCLEASE 8-LIKE 3 nuclease activity#GO:0004518;DNA endonuclease activity#GO:0004520;hydrolase activity#GO:0016787;DNA N-glycosylase activity#GO:0019104;endonuclease activity#GO:0004519;catalytic activity, acting on DNA#GO:0140097;hydrolase activity, acting on glycosyl bonds#GO:0016798;DNA nuclease activity#GO:0004536;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640 macromolecule metabolic process#GO:0043170;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139;response to stress#GO:0006950;base-excision repair#GO:0006284;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA glycosylase#PC00010 HUMAN|HGNC=25666|UniProtKB=Q7L5A3 Q7L5A3 ATOSB PTHR13199:SF12 GH03947P ATOS HOMOLOG PROTEIN B HUMAN|HGNC=16005|UniProtKB=Q9Y543 Q9Y543 HES2 PTHR10985:SF15 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED TRANSCRIPTION FACTOR HES-2 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;regulation of multicellular organismal development#GO:2000026;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;multicellular organism development#GO:0007275;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;anterior/posterior pattern specification#GO:0009952;regulation of multicellular organismal process#GO:0051239;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of DNA-templated transcription#GO:0006355;regulation of nervous system development#GO:0051960;anatomical structure development#GO:0048856;pattern specification process#GO:0007389;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of neurogenesis#GO:0050767;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of cell differentiation#GO:0045595;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regionalization#GO:0003002;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cell development#GO:0060284;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 basic helix-loop-helix transcription factor#PC00055 Notch signaling pathway#P00045>E(spl)-C genes#G01541 HUMAN|HGNC=9948|UniProtKB=P46063 P46063 RECQL PTHR13710:SF162 DNA HELICASE RECQ FAMILY MEMBER ATP-DEPENDENT DNA HELICASE Q1 nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543;helicase activity#GO:0004386;catalytic activity, acting on DNA#GO:0140097;DNA helicase activity#GO:0003678;isomerase activity#GO:0016853;3'-5' DNA helicase activity#GO:0043138;ATP-dependent activity#GO:0140657;ATP-dependent activity, acting on DNA#GO:0008094 response to stimulus#GO:0050896;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular response to stimulus#GO:0051716;DNA replication#GO:0006260;double-strand break repair via homologous recombination#GO:0000724;recombinational repair#GO:0000725;cellular response to stress#GO:0033554;nucleobase-containing compound metabolic process#GO:0006139;response to stress#GO:0006950;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;double-strand break repair#GO:0006302;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;DNA recombination#GO:0006310;DNA damage response#GO:0006974 chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 DNA metabolism protein#PC00009;DNA helicase#PC00011 HUMAN|HGNC=12958|UniProtKB=P17021 P17021 ZNF17 PTHR24377:SF992 IP01015P-RELATED ZINC FINGER PROTEIN 17-RELATED sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=10937|UniProtKB=P41440 P41440 SLC19A1 PTHR10686:SF12 FOLATE TRANSPORTER REDUCED FOLATE TRANSPORTER antiporter activity#GO:0015297;monoatomic anion transmembrane transporter activity#GO:0008509;secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;heterocyclic compound binding#GO:1901363;monoatomic ion transmembrane transporter activity#GO:0015075;binding#GO:0005488;carboxylic acid binding#GO:0031406;transmembrane transporter activity#GO:0022857;dicarboxylic acid transmembrane transporter activity#GO:0005310;active transmembrane transporter activity#GO:0022804;small molecule binding#GO:0036094;anion binding#GO:0043168;ion binding#GO:0043167;organic acid binding#GO:0043177;carboxylic acid transmembrane transporter activity#GO:0046943 vitamin transport#GO:0051180;carboxylic acid transmembrane transport#GO:1905039;dicarboxylic acid transport#GO:0006835;nitrogen compound transport#GO:0071705;cellular process#GO:0009987;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;transport#GO:0006810;carboxylic acid transport#GO:0046942;organic acid transport#GO:0015849 apical part of cell#GO:0045177;basal plasma membrane#GO:0009925;cell periphery#GO:0071944;apical plasma membrane#GO:0016324;basal part of cell#GO:0045178;basolateral plasma membrane#GO:0016323;membrane#GO:0016020;plasma membrane#GO:0005886;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165 transporter#PC00227 HUMAN|HGNC=6190|UniProtKB=P23458 P23458 JAK1 PTHR45807:SF5 TYROSINE-PROTEIN KINASE HOPSCOTCH TYROSINE-PROTEIN KINASE JAK1 transferase activity#GO:0016740;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;hormone receptor binding#GO:0051427;signaling receptor binding#GO:0005102;cytokine receptor binding#GO:0005126;binding#GO:0005488;non-membrane spanning protein tyrosine kinase activity#GO:0004715;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein binding#GO:0005515;protein kinase activity#GO:0004672 cell surface receptor signaling pathway#GO:0007166;response to chemical#GO:0042221;response to cytokine#GO:0034097;defense response to other organism#GO:0098542;interleukin-9-mediated signaling pathway#GO:0038113;interleukin-15-mediated signaling pathway#GO:0035723;cell surface receptor signaling pathway via STAT#GO:0097696;response to biotic stimulus#GO:0009607;response to hormone#GO:0009725;response to stress#GO:0006950;defense response to symbiont#GO:0140546;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987;response to type II interferon#GO:0034341;response to peptide#GO:1901652;cellular response to chemical stimulus#GO:0070887;immune system process#GO:0002376;type I interferon-mediated signaling pathway#GO:0060337;response to oxygen-containing compound#GO:1901700;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;cell differentiation#GO:0030154;cellular response to hormone stimulus#GO:0032870;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;response to endogenous stimulus#GO:0009719;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;innate immune response#GO:0045087;cellular developmental process#GO:0048869;response to external stimulus#GO:0009605;defense response#GO:0006952;developmental process#GO:0032502;cell surface receptor signaling pathway via JAK-STAT#GO:0007259;cellular response to nitrogen compound#GO:1901699;biological regulation#GO:0065007;response to other organism#GO:0051707;response to peptide hormone#GO:0043434;immune response#GO:0006955;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;response to nitrogen compound#GO:1901698;intracellular signal transduction#GO:0035556;cytokine-mediated signaling pathway#GO:0019221;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of cellular process#GO:0050794;response to external biotic stimulus#GO:0043207;cellular response to peptide hormone stimulus#GO:0071375;interleukin-2-mediated signaling pathway#GO:0038110;cellular response to stimulus#GO:0051716 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 non-receptor tyrosine protein kinase#PC00168 Interferon-gamma signaling pathway#P00035>Jak1#P00953;JAK/STAT signaling pathway#P00038>Jak#P01034;Angiogenesis#P00005>JAK1#P00185;PDGF signaling pathway#P00047>Jak#P01155 HUMAN|HGNC=8747|UniProtKB=Q92824 Q92824 PCSK5 PTHR42884:SF7 PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED PROPROTEIN CONVERTASE SUBTILISIN_KEXIN TYPE 5 serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233 metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;peptide hormone processing#GO:0016486;cellular process#GO:0009987;protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059;hormone metabolic process#GO:0042445;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;biological regulation#GO:0065007;proteolysis#GO:0006508;signaling receptor ligand precursor processing#GO:0140448;protein metabolic process#GO:0019538;regulation of biological quality#GO:0065008;primary metabolic process#GO:0044238;regulation of hormone levels#GO:0010817 intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;endomembrane system#GO:0012505;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020 serine protease#PC00203 Alzheimer disease-amyloid secretase pathway#P00003>Furin#P00105;Alzheimer disease-presenilin pathway#P00004>Furin#P00157 HUMAN|HGNC=12666|UniProtKB=P55072 P55072 VCP PTHR23077:SF69 AAA-FAMILY ATPASE TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;polyubiquitin modification-dependent protein binding#GO:0031593;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;ATP-dependent activity#GO:0140657;modification-dependent protein binding#GO:0140030;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP hydrolysis activity#GO:0016887;protein binding#GO:0005515;hydrolase activity#GO:0016787 macroautophagy#GO:0016236;macromolecule localization#GO:0033036;macromolecule metabolic process#GO:0043170;spindle organization#GO:0007051;establishment of localization#GO:0051234;mitotic cell cycle process#GO:1903047;intracellular protein localization#GO:0008104;ubiquitin-dependent protein catabolic process#GO:0006511;autophagosome maturation#GO:0097352;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;transport#GO:0006810;mitotic cell cycle#GO:0000278;catabolic process#GO:0009056;protein-containing complex disassembly#GO:0032984;cell cycle#GO:0007049;microtubule cytoskeleton organization involved in mitosis#GO:1902850;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular response to stimulus#GO:0051716;localization#GO:0051179;protein metabolic process#GO:0019538;microtubule cytoskeleton organization#GO:0000226;ERAD pathway#GO:0036503;response to endoplasmic reticulum stress#GO:0034976;response to chemical#GO:0042221;cytoskeleton organization#GO:0007010;proteasomal protein catabolic process#GO:0010498;organelle organization#GO:0006996;response to stress#GO:0006950;autophagy#GO:0006914;establishment of protein localization#GO:0045184;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;protein-containing complex organization#GO:0043933;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;response to stimulus#GO:0050896;mitotic spindle organization#GO:0007052;cellular component organization#GO:0016043;cell cycle process#GO:0022402;organelle disassembly#GO:1903008;cellular component disassembly#GO:0022411;process utilizing autophagic mechanism#GO:0061919;protein transport#GO:0015031;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632 endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;cytosol#GO:0005829;membrane#GO:0016020;nucleus#GO:0005634;endoplasmic reticulum protein-containing complex#GO:0140534;organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229 primary active transporter#PC00068;transporter#PC00227 HUMAN|HGNC=11322|UniProtKB=Q14714 Q14714 SSPN PTHR15260:SF1 SARCOSPAN SARCOSPAN plasma membrane#GO:0005886;sarcolemma#GO:0042383;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=14679|UniProtKB=Q969I6 Q969I6 SLC38A4 PTHR22950:SF222 AMINO ACID TRANSPORTER SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 4 L-amino acid transmembrane transporter activity#GO:0015179;amino acid transmembrane transporter activity#GO:0015171;transporter activity#GO:0005215;carboxylic acid transmembrane transporter activity#GO:0046943;transmembrane transporter activity#GO:0022857;neutral L-amino acid transmembrane transporter activity#GO:0015175 carboxylic acid transport#GO:0046942;transport#GO:0006810;organic acid transport#GO:0015849;amino acid transport#GO:0006865;localization#GO:0051179;establishment of localization#GO:0051234;neutral amino acid transport#GO:0015804;transmembrane transport#GO:0055085;amino acid transmembrane transport#GO:0003333;cellular process#GO:0009987;L-amino acid transport#GO:0015807;nitrogen compound transport#GO:0071705 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258;amino acid transporter#PC00046 HUMAN|HGNC=22402|UniProtKB=Q8TBZ9 Q8TBZ9 TEX47 PTHR34035:SF1 TESTIS-EXPRESSED PROTEIN 47 TESTIS-EXPRESSED PROTEIN 47 HUMAN|HGNC=34418|UniProtKB=Q86W67 Q86W67 FAM228A PTHR28584:SF2 FAMILY WITH SEQUENCE SIMILARITY 228 MEMBER A PROTEIN FAM228A HUMAN|HGNC=29413|UniProtKB=Q6NYC8 Q6NYC8 PPP1R18 PTHR21685:SF0 TON-B BOX DOMAIN PHOSTENSIN HUMAN|HGNC=18341|UniProtKB=Q9Y2J8 Q9Y2J8 PADI2 PTHR10837:SF12 PEPTIDYLARGININE DEIMINASE PROTEIN-ARGININE DEIMINASE TYPE-2 catalytic activity#GO:0003824;histone modifying activity#GO:0140993;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;chromatin remodeling#GO:0006338;chromatin organization#GO:0006325 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=18118|UniProtKB=Q96T23 Q96T23 RSF1 PTHR14296:SF16 REMODELING AND SPACING FACTOR 1 REMODELING AND SPACING FACTOR 1 binding#GO:0005488;histone binding#GO:0042393;protein binding#GO:0005515 negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;negative regulation of gene expression, epigenetic#GO:0045814;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;epigenetic regulation of gene expression#GO:0040029;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;cellular component biogenesis#GO:0044085;heterochromatin organization#GO:0070828;regulation of RNA biosynthetic process#GO:2001141;chromatin organization#GO:0006325;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular component assembly#GO:0022607;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;heterochromatin formation#GO:0031507;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255 protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;chromatin#GO:0000785;nucleus#GO:0005634;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;SWI/SNF superfamily-type complex#GO:0070603;ISWI-type complex#GO:0031010;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ATPase complex#GO:1904949;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 HUMAN|HGNC=24321|UniProtKB=Q7Z401 Q7Z401 DENND4A PTHR12296:SF16 DENN DOMAIN-CONTAINING PROTEIN 4 C-MYC PROMOTER-BINDING PROTEIN nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of biological process#GO:0050789;regulation of small GTPase mediated signal transduction#GO:0051056;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;vesicle#GO:0031982;intracellular vesicle#GO:0097708;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 guanyl-nucleotide exchange factor#PC00113;protein-binding activity modulator#PC00095 HUMAN|HGNC=13238|UniProtKB=Q9HDC9 Q9HDC9 APMAP PTHR10426:SF130 STRICTOSIDINE SYNTHASE-RELATED ADIPOCYTE PLASMA MEMBRANE-ASSOCIATED PROTEIN hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 HUMAN|HGNC=11774|UniProtKB=Q03167 Q03167 TGFBR3 PTHR14002:SF7 ENDOGLIN/TGF-BETA RECEPTOR TYPE III TRANSFORMING GROWTH FACTOR BETA RECEPTOR TYPE 3 signaling receptor binding#GO:0005102;glycosaminoglycan binding#GO:0005539;molecular transducer activity#GO:0060089;catalytic activity#GO:0003824;transforming growth factor beta binding#GO:0050431;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;cytokine binding#GO:0019955;transmembrane receptor protein kinase activity#GO:0019199;cytokine receptor binding#GO:0005126;binding#GO:0005488;protein serine/threonine kinase activity#GO:0004674;transmembrane signaling receptor activity#GO:0004888;growth factor binding#GO:0019838;transmembrane receptor protein serine/threonine kinase activity#GO:0004675;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein binding#GO:0005515;protein kinase activity#GO:0004672;transferase activity#GO:0016740;carbohydrate derivative binding#GO:0097367;kinase activity#GO:0016301;transforming growth factor beta receptor activity#GO:0005024;signaling receptor activity#GO:0038023 cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;response to transforming growth factor beta#GO:0071559;regulation of cell communication#GO:0010646;response to growth factor#GO:0070848;regulation of cellular process#GO:0050794;regulation of transforming growth factor beta receptor signaling pathway#GO:0017015;cellular response to transforming growth factor beta stimulus#GO:0071560;cellular response to stimulus#GO:0051716;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092;mesenchyme development#GO:0060485;cellular developmental process#GO:0048869;developmental process#GO:0032502;regulation of response to stimulus#GO:0048583;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cellular response to growth factor stimulus#GO:0090287;tissue development#GO:0009888;cellular response to growth factor stimulus#GO:0071363;regulation of signaling#GO:0023051;animal gross anatomical part developmental process#GO:0160108;signaling#GO:0023052;response to stimulus#GO:0050896;cell differentiation#GO:0030154;cellular response to endogenous stimulus#GO:0071495;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;animal organ development#GO:0048513;mesenchymal cell differentiation#GO:0048762;cell surface receptor signaling pathway#GO:0007166;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;signal transduction#GO:0007165;cellular process#GO:0009987;transforming growth factor beta receptor signaling pathway#GO:0007179 transmembrane signal receptor#PC00197 Gonadotropin-releasing hormone receptor pathway#P06664>TBRIII#P06806 HUMAN|HGNC=14568|UniProtKB=Q9BYT3 Q9BYT3 STK33 PTHR44167:SF6 OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED SERINE_THREONINE-PROTEIN KINASE 33 kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=29361|UniProtKB=Q9C0D9 Q9C0D9 SELENOI PTHR10414:SF47 ETHANOLAMINEPHOSPHOTRANSFERASE ETHANOLAMINEPHOSPHOTRANSFERASE 1 transferase#PC00220 HUMAN|HGNC=43734|UniProtKB=P0DPK5 P0DPK5 H3Y2 PTHR11426:SF263 HISTONE H3 HISTONE H3.X-RELATED organelle fission#GO:0048285;localization#GO:0051179;kinetochore organization#GO:0051383;kinetochore assembly#GO:0051382;nuclear division#GO:0000280;organelle localization#GO:0051640;organelle assembly#GO:0070925;mitotic cell cycle#GO:0000278;cell cycle process#GO:0022402;mitotic nuclear division#GO:0140014;protein-containing complex assembly#GO:0065003;mitotic metaphase chromosome alignment#GO:0007080;nuclear chromosome segregation#GO:0098813;sister chromatid segregation#GO:0000819;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;cell cycle#GO:0007049;protein-containing complex organization#GO:0043933;chromosome organization#GO:0051276;mitotic cell cycle process#GO:1903047;cellular component organization or biogenesis#GO:0071840;chromosome segregation#GO:0007059;metaphase chromosome alignment#GO:0051310;chromosome localization#GO:0050000;cellular component assembly#GO:0022607;cellular process#GO:0009987;mitotic sister chromatid segregation#GO:0000070;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=4405|UniProtKB=P63215 P63215 GNG3 PTHR13809:SF11 GUANINE NUCLEOTIDE-BINDING PROTEIN GAMMA SUBUNIT GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)_G(S)_G(O) SUBUNIT GAMMA-3 molecular function regulator activity#GO:0098772;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;cytoplasmic side of plasma membrane#GO:0009898;membrane#GO:0016020;extrinsic component of membrane#GO:0019898;extrinsic component of plasma membrane#GO:0019897;side of membrane#GO:0098552;catalytic complex#GO:1902494;cytoplasmic side of membrane#GO:0098562;extrinsic component of cytoplasmic side of plasma membrane#GO:0031234 heterotrimeric G-protein#PC00117 Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>G-Protein#P01085;Cortocotropin releasing factor receptor signaling pathway#P04380>G-Protein#P04458;Oxytocin receptor mediated signaling pathway#P04391>G-Protein#P04534;Opioid proopiomelanocortin pathway#P05917>G-protein#P06012;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>G-Protein#P01073;5HT4 type receptor mediated signaling pathway#P04376>G-protein#P04430;Metabotropic glutamate receptor group III pathway#P00039>G-Protein#P01045;Angiotensin II-stimulated signaling through G proteins and beta-arrestin#P05911>Ggamma#P05929;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Gbetagamma#P00836;Enkephalin release#P05913>G-Protein (s)#P05977;Enkephalin release#P05913>G-Protein (i)#P05974;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Ggamma#P00751;5HT2 type receptor mediated signaling pathway#P04374>G-protein#P04416;Thyrotropin-releasing hormone receptor signaling pathway#P04394>G-Protein#P04584;GABA-B receptor II signaling#P05731>Ggamma#P05754;5HT1 type receptor mediated signaling pathway#P04373>G-protein#P04408;Opioid proenkephalin pathway#P05915>G-protein#P05994;Histamine H1 receptor mediated signaling pathway#P04385>G-Protein#P04488;Beta2 adrenergic receptor signaling pathway#P04378>G-Protein#P04443;Dopamine receptor mediated signaling pathway#P05912>Ggamma#P05967;Histamine H2 receptor mediated signaling pathway#P04386>G-Protein#P04490;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Ggamma#P00721;Endogenous cannabinoid signaling#P05730>Ggamma#P05744;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GIRK#P00743;Wnt signaling pathway#P00057>Ggamma#P01465;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Ggamma#P00726;Metabotropic glutamate receptor group II pathway#P00040>G-protein#P01047;Beta1 adrenergic receptor signaling pathway#P04377>G-Protein#P04436;Opioid prodynorphin pathway#P05916>G-protein#P06002;Beta3 adrenergic receptor signaling pathway#P04379>G-Protein#P04448 HUMAN|HGNC=33627|UniProtKB=Q8NCU7 Q8NCU7 C2CD4A PTHR47226:SF3 C2 CALCIUM-DEPENDENT DOMAIN-CONTAINING PROTEIN 4A C2 CALCIUM-DEPENDENT DOMAIN-CONTAINING PROTEIN 4A circulatory system process#GO:0003013;inflammatory response#GO:0006954;acute inflammatory response#GO:0002526;system process#GO:0003008;defense response#GO:0006952;regulation of biological quality#GO:0065008;response to stress#GO:0006950;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;blood circulation#GO:0008015;multicellular organismal process#GO:0032501;regulation of cell adhesion#GO:0030155;regulation of cellular process#GO:0050794;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=8004|UniProtKB=O14786 O14786 NRP1 PTHR46806:SF4 F5/8 TYPE C DOMAIN-CONTAINING PROTEIN NEUROPILIN-1 transferase activity, transferring phosphorus-containing groups#GO:0016772;protein tyrosine kinase activity#GO:0004713;catalytic activity#GO:0003824;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity, acting on a protein#GO:0140096;transmembrane receptor protein tyrosine kinase activity#GO:0004714;molecular transducer activity#GO:0060089;kinase activity#GO:0016301;transferase activity#GO:0016740;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488;protein kinase activity#GO:0004672;protein binding#GO:0005515;growth factor binding#GO:0019838;phosphotransferase activity, alcohol group as acceptor#GO:0016773 cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;cell motility#GO:0048870;regulation of cell communication#GO:0010646;stem cell development#GO:0048864;positive regulation of cell projection organization#GO:0031346;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;anatomical structure development#GO:0048856;axon guidance#GO:0007411;positive regulation of cell migration#GO:0030335;positive regulation of cellular process#GO:0048522;multicellular organismal process#GO:0032501;regulation of locomotion#GO:0040012;biological regulation#GO:0065007;regulation of cell projection organization#GO:0031344;neuron projection morphogenesis#GO:0048812;regulation of response to stimulus#GO:0048583;regulation of cell migration#GO:0030334;regulation of plasma membrane bounded cell projection organization#GO:0120035;neurogenesis#GO:0022008;mesenchyme development#GO:0060485;positive regulation of locomotion#GO:0040017;regulation of filopodium assembly#GO:0051489;neuron projection guidance#GO:0097485;vascular endothelial growth factor receptor signaling pathway#GO:0048010;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;cell morphogenesis#GO:0000902;regulation of cellular component organization#GO:0051128;regulation of plasma membrane bounded cell projection assembly#GO:0120032;response to stimulus#GO:0050896;regulation of cellular component biogenesis#GO:0044087;cell development#GO:0048468;animal gross anatomical part developmental process#GO:0160108;regulation of signaling#GO:0023051;angiogenesis#GO:0001525;axonogenesis#GO:0007409;neuron development#GO:0048666;neuron projection development#GO:0031175;cellular process#GO:0009987;neural crest cell migration#GO:0001755;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of cellular component biogenesis#GO:0044089;vasculogenesis#GO:0001570;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;neuron differentiation#GO:0030182;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;vasculature development#GO:0001944;anatomical structure formation involved in morphogenesis#GO:0048646;tube morphogenesis#GO:0035239;blood vessel development#GO:0001568;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of cell motility#GO:2000145;cell communication#GO:0007154;regulation of cell projection assembly#GO:0060491;system development#GO:0048731;axon development#GO:0061564;stem cell differentiation#GO:0048863;response to wounding#GO:0009611;neural crest cell development#GO:0014032;cell migration#GO:0016477;tissue development#GO:0009888;tube development#GO:0035295;plasma membrane bounded cell projection organization#GO:0120036;regulation of cellular response to growth factor stimulus#GO:0090287;regulation of signal transduction#GO:0009966;developmental process#GO:0032502;cellular developmental process#GO:0048869;blood vessel morphogenesis#GO:0048514;cellular component organization#GO:0016043;positive regulation of cell motility#GO:2000147;cell projection organization#GO:0030030;circulatory system development#GO:0072359;cell differentiation#GO:0030154;signaling#GO:0023052;sprouting angiogenesis#GO:0002040;generation of neurons#GO:0048699;positive regulation of cellular component organization#GO:0051130;response to stress#GO:0006950;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell surface receptor signaling pathway#GO:0007166;mesenchymal cell differentiation#GO:0048762;neural crest cell differentiation#GO:0014033;animal organ development#GO:0048513;cell projection morphogenesis#GO:0048858 membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cell projection#GO:0042995;cell-substrate junction#GO:0030055;focal adhesion#GO:0005925;plasma membrane bounded cell projection#GO:0120025;axon#GO:0030424;cell junction#GO:0030054;anchoring junction#GO:0070161 Axon guidance mediated by semaphorins#P00007>Neuropilin 1#P00338 HUMAN|HGNC=3057|UniProtKB=Q9Y4J8 Q9Y4J8 DTNA PTHR12268:SF19 E3 UBIQUITIN-PROTEIN LIGASE KCMF1 DYSTROBREVIN ALPHA cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cell junction#GO:0030054;synapse#GO:0045202;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=26169|UniProtKB=Q2NKJ3 Q2NKJ3 CTC1 PTHR14865:SF2 CST COMPLEX SUBUNIT CTC1 CST COMPLEX SUBUNIT CTC1 telomeric repeat DNA binding#GO:0042162;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;single-stranded DNA binding#GO:0003697;binding#GO:0005488;nucleic acid binding#GO:0003676 metabolic process#GO:0008152;DNA metabolic process#GO:0006259;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;telomere maintenance#GO:0000723;chromosome organization#GO:0051276;regulation of primary metabolic process#GO:0080090;organelle organization#GO:0006996;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of DNA replication#GO:0045740;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;telomere maintenance via telomere lengthening#GO:0010833;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;positive regulation of metabolic process#GO:0009893;regulation of DNA replication#GO:0006275;telomere organization#GO:0032200;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;positive regulation of DNA metabolic process#GO:0051054;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of DNA metabolic process#GO:0051052;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;nucleus#GO:0005634;intracellular membraneless organelle#GO:0043232;chromosome, telomeric region#GO:0000781;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;chromosome, telomeric repeat region#GO:0140445;membrane-bounded organelle#GO:0043227;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;nuclear telomere cap complex#GO:0000783;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-DNA complex#GO:0032993;cellular anatomical structure#GO:0110165 HUMAN|HGNC=1144|UniProtKB=Q9Y297 Q9Y297 BTRC PTHR14604:SF5 WD40 REPEAT PF20 F-BOX_WD REPEAT-CONTAINING PROTEIN 1A protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;enzyme-substrate adaptor activity#GO:0140767;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941 transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular protein-containing complex#GO:0140535;SCF ubiquitin ligase complex#GO:0019005;cullin-RING ubiquitin ligase complex#GO:0031461;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991 microtubule or microtubule-binding cytoskeletal protein#PC00157 Wnt signaling pathway#P00057>betaTrCP#P01454;Hedgehog signaling pathway#P00025>Slimb#P00683 HUMAN|HGNC=21339|UniProtKB=O60522 O60522 TDRD6 PTHR22948:SF15 TUDOR DOMAIN CONTAINING PROTEIN TUDOR DOMAIN-CONTAINING PROTEIN 6 scaffold/adaptor protein#PC00226 HUMAN|HGNC=8108|UniProtKB=Q01968 Q01968 OCRL PTHR11200:SF176 INOSITOL 5-PHOSPHATASE INOSITOL POLYPHOSPHATE 5-PHOSPHATASE OCRL hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788 neuron projection#GO:0043005;membrane#GO:0016020;cell projection#GO:0042995;intracellular anatomical structure#GO:0005622;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 phosphatase#PC00181;hydrolase#PC00121 HUMAN|HGNC=23801|UniProtKB=O60292 O60292 SIPA1L3 PTHR15711:SF15 RAP GTPASE-ACTIVATING PROTEIN SIGNAL-INDUCED PROLIFERATION-ASSOCIATED 1-LIKE PROTEIN 3 enzyme activator activity#GO:0008047;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 developmental process#GO:0032502;animal gross anatomical part developmental process#GO:0160108;establishment or maintenance of cell polarity#GO:0007163;cellular developmental process#GO:0048869;anatomical structure development#GO:0048856;cellular process#GO:0009987;establishment of cell polarity#GO:0030010;anatomical structure morphogenesis#GO:0009653;cell development#GO:0048468;epithelial cell differentiation#GO:0030855;cell morphogenesis#GO:0000902;tissue development#GO:0009888;cell differentiation#GO:0030154;epithelium development#GO:0060429 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein modulator#PC00022;GTPase-activating protein#PC00257 HUMAN|HGNC=8549|UniProtKB=Q9UL45 Q9UL45 BLOC1S6 PTHR31328:SF2 BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 6 BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 6 establishment of organelle localization#GO:0051656;organelle localization#GO:0051640;pigmentation#GO:0043473;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization in cell#GO:0051649;vesicle localization#GO:0051648;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;synaptic vesicle recycling#GO:0036465;establishment of vesicle localization#GO:0051650;cellular pigmentation#GO:0033059;intracellular transport#GO:0046907;synaptic vesicle cycle#GO:0099504;transport#GO:0006810;vesicle-mediated transport in synapse#GO:0099003;establishment of localization#GO:0051234;endosomal transport#GO:0016197 intracellular vesicle#GO:0097708;actin cytoskeleton#GO:0015629;postsynapse#GO:0098794;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;synapse#GO:0045202;cell-substrate junction#GO:0030055;focal adhesion#GO:0005925;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;actin filament bundle#GO:0032432;membrane-bounded organelle#GO:0043227;BLOC-1 complex#GO:0031083;anchoring junction#GO:0070161;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;cell-cell junction#GO:0005911;actomyosin#GO:0042641;transport vesicle#GO:0030133;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;stress fiber#GO:0001725;cytoskeleton#GO:0005856;cell junction#GO:0030054;membraneless organelle#GO:0043228;neuromuscular junction#GO:0031594;cell-cell contact zone#GO:0044291;intracellular protein-containing complex#GO:0140535 HUMAN|HGNC=367|UniProtKB=Q92667 Q92667 AKAP1 PTHR22948:SF75 TUDOR DOMAIN CONTAINING PROTEIN A-KINASE ANCHOR PROTEIN 1, MITOCHONDRIAL protein kinase A binding#GO:0051018;binding#GO:0005488;protein kinase A regulatory subunit binding#GO:0034237;protein binding#GO:0005515 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 CCKR signaling map#P06959>AKAP#P07184 HUMAN|HGNC=658|UniProtKB=P84085 P84085 ARF5 PTHR11711:SF489 ADP RIBOSYLATION FACTOR-RELATED ADP-RIBOSYLATION FACTOR 5 nucleotide binding#GO:0000166;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;guanyl nucleotide binding#GO:0019001;nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;binding#GO:0005488 vesicle-mediated transport#GO:0016192;macromolecule localization#GO:0033036;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;intracellular protein localization#GO:0008104;protein transport#GO:0015031;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 G-protein#PC00020 Huntington disease#P00029>ARF#P00786 HUMAN|HGNC=327|UniProtKB=O00116 O00116 AGPS PTHR46568:SF1 ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE, PEROXISOMAL ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE, PEROXISOMAL transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;catalytic activity#GO:0003824;transferase activity#GO:0016740 biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;lipid metabolic process#GO:0006629;cellular process#GO:0009987;primary metabolic process#GO:0044238;metabolic process#GO:0008152 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;peroxisome#GO:0005777;microbody#GO:0042579;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=52279|UniProtKB=A0A8I5KY20 A0A8I5KY20 CCDC92B PTHR14882:SF3 COILED-COIL DOMAIN-CONTAINING 74A COILED-COIL DOMAIN-CONTAINING 92B HUMAN|HGNC=24718|UniProtKB=Q96JJ7 Q96JJ7 TMX3 PTHR46426:SF1 PROTEIN DISULFIDE-ISOMERASE TMX3 PROTEIN DISULFIDE-ISOMERASE TMX3 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cell surface#GO:0009986;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 chaperone#PC00072 HUMAN|HGNC=29419|UniProtKB=Q5JPH6 Q5JPH6 EARS2 PTHR43311:SF2 GLUTAMATE--TRNA LIGASE NONDISCRIMINATING GLUTAMYL-TRNA SYNTHETASE EARS2, MITOCHONDRIAL catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;ligase activity#GO:0016874;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;protein biosynthetic process#GO:0160307;translation#GO:0006412;RNA metabolic process#GO:0016070;protein metabolic process#GO:0019538;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;tRNA aminoacylation for protein translation#GO:0006418;tRNA aminoacylation#GO:0043039;amino acid metabolic process#GO:0006520;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;amino acid activation#GO:0043038;macromolecule metabolic process#GO:0043170 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 aminoacyl-tRNA synthetase#PC00047 Heme biosynthesis#P02746>Glutamyl-tRNA-synthetase#P02977 HUMAN|HGNC=15678|UniProtKB=P0DPB3 P0DPB3 SCHIP1 PTHR13103:SF2 SCHWANNOMIN INTERACTING PROTEIN 1 IQCJ-SCHIP1 READTHROUGH TRANSCRIPT PROTEIN-RELATED positive regulation of signaling#GO:0023056;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of hippo signaling#GO:0035330;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522 cellular anatomical structure#GO:0110165;cell junction#GO:0030054;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HUMAN|HGNC=7577|UniProtKB=P12883 P12883 MYH7 PTHR45615:SF1 MYOSIN HEAVY CHAIN, NON-MUSCLE MYOSIN-7 isomerase activity#GO:0016853;cytoskeletal motor activity#GO:0003774;macromolecular conformation isomerase activity#GO:0120543;cytoskeletal protein binding#GO:0008092;catalytic activity#GO:0003824;microfilament motor activity#GO:0000146;protein-containing complex binding#GO:0044877;protein binding#GO:0005515;actin filament binding#GO:0051015;actin binding#GO:0003779;ATP-dependent activity#GO:0140657;binding#GO:0005488;polypeptide conformation or assembly isomerase activity#GO:0120544 striated muscle contraction#GO:0006941;circulatory system development#GO:0072359;actin-mediated cell contraction#GO:0070252;muscle system process#GO:0003012;heart process#GO:0003015;system development#GO:0048731;anatomical structure development#GO:0048856;cardiac muscle contraction#GO:0060048;actin filament-based process#GO:0030029;circulatory system process#GO:0003013;animal gross anatomical part developmental process#GO:0160108;heart development#GO:0007507;blood circulation#GO:0008015;multicellular organismal process#GO:0032501;cellular process#GO:0009987;actin filament-based movement#GO:0030048;heart contraction#GO:0060047;system process#GO:0003008;multicellular organism development#GO:0007275;animal organ development#GO:0048513;muscle contraction#GO:0006936;developmental process#GO:0032502 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membraneless organelle#GO:0043228;myosin complex#GO:0016459;actin cytoskeleton#GO:0015629;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;supramolecular complex#GO:0099080;organelle#GO:0043226 actin or actin-binding cytoskeletal protein#PC00041 Wnt signaling pathway#P00057>NFAT Target Genes#G01559;Cytoskeletal regulation by Rho GTPase#P00016>Myosin#P00522;Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Myosin#P00867 HUMAN|HGNC=16085|UniProtKB=Q9H9B4 Q9H9B4 SFXN1 PTHR11153:SF8 SIDEROFLEXIN SIDEROFLEXIN-1 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 mitochondrial transmembrane transport#GO:1990542;neutral amino acid transport#GO:0015804;cellular localization#GO:0051641;transmembrane transport#GO:0055085;amino acid transmembrane transport#GO:0003333;localization#GO:0051179;carboxylic acid transmembrane transport#GO:1905039;mitochondrial transport#GO:0006839;carboxylic acid transport#GO:0046942;transport#GO:0006810;organic acid transport#GO:0015849;amino acid transport#GO:0006865;intracellular transport#GO:0046907;establishment of localization#GO:0051234;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;nitrogen compound transport#GO:0071705 intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;organelle envelope#GO:0031967;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966 primary active transporter#PC00068 HUMAN|HGNC=15886|UniProtKB=Q9Y312 Q9Y312 AAR2 PTHR12689:SF4 A1 CISTRON SPLICING FACTOR AAR2-RELATED PROTEIN AAR2 HOMOLOG macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;gene expression#GO:0010467;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;mRNA cis splicing, via spliceosome#GO:0045292;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398 nucleus#GO:0005634;small nuclear ribonucleoprotein complex#GO:0030532;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;spliceosomal snRNP complex#GO:0097525;nuclear protein-containing complex#GO:0140513;Sm-like protein family complex#GO:0120114;U5 snRNP#GO:0005682 RNA splicing factor#PC00148 HUMAN|HGNC=4224|UniProtKB=O60383 O60383 GDF9 PTHR11848:SF19 TGF-BETA FAMILY GROWTH_DIFFERENTIATION FACTOR 9 signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;cytokine activity#GO:0005125;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677 cell surface receptor signaling pathway#GO:0007166;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 growth factor#PC00112 TGF-beta signaling pathway#P00052>TGFbeta#P01286 HUMAN|HGNC=14666|UniProtKB=Q8TDU9 Q8TDU9 RXFP4 PTHR24230:SF32 G-PROTEIN COUPLED RECEPTOR RELAXIN-3 RECEPTOR 2 molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;signaling receptor activity#GO:0038023;neuropeptide receptor activity#GO:0008188;transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;neuropeptide signaling pathway#GO:0007218;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021 HUMAN|HGNC=44|UniProtKB=Q03519 Q03519 TAP2 PTHR24221:SF237 ATP-BINDING CASSETTE SUB-FAMILY B ANTIGEN PEPTIDE TRANSPORTER 2 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657;active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399 cellular process#GO:0009987;transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085 endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;membrane protein complex#GO:0098796;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;organelle membrane#GO:0031090;endoplasmic reticulum protein-containing complex#GO:0140534;membrane#GO:0016020;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasm#GO:0005737 ATP-binding cassette (ABC) transporter#PC00003 HUMAN|HGNC=37237|UniProtKB=A6NDY0 A6NDY0 PABPN1L PTHR23236:SF27 EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H EMBRYONIC POLYADENYLATE-BINDING PROTEIN 2 poly(A) binding#GO:0008143;binding#GO:0005488;nucleic acid binding#GO:0003676;single-stranded RNA binding#GO:0003727;RNA binding#GO:0003723 metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;positive regulation of mRNA metabolic process#GO:1903313;mRNA destabilization#GO:0061157;regulation of mRNA metabolic process#GO:1903311;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;RNA destabilization#GO:0050779;positive regulation of macromolecule metabolic process#GO:0010604;RNA catabolic process#GO:0006401;regulation of biological quality#GO:0065008;positive regulation of metabolic process#GO:0009893;RNA metabolic process#GO:0016070;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;negative regulation of gene expression#GO:0010629;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;regulation of mRNA stability#GO:0043488;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;macromolecule metabolic process#GO:0043170;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;positive regulation of catabolic process#GO:0009896;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;nucleic acid catabolic process#GO:0141188;nucleobase-containing compound catabolic process#GO:0034655;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA stability#GO:0043487;regulation of RNA metabolic process#GO:0051252;positive regulation of mRNA catabolic process#GO:0061014;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;positive regulation of RNA metabolic process#GO:0051254;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 translation factor#PC00223;translation initiation factor#PC00224;translational protein#PC00263 HUMAN|HGNC=21043|UniProtKB=Q9BZ71 Q9BZ71 PITPNM3 PTHR23509:SF22 PA-PL1 PHOSPHOLIPASE FAMILY MEMBRANE-ASSOCIATED PHOSPHATIDYLINOSITOL TRANSFER PROTEIN 3 hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phospholipase activity#GO:0120569;catalytic activity#GO:0003824;glycerophospholipase activity#GO:0004620;lipase activity#GO:0016298 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;phospholipase#PC00186 HUMAN|HGNC=21100|UniProtKB=Q96PU8 Q96PU8 QKI PTHR11208:SF42 RNA-BINDING PROTEIN RELATED KH DOMAIN-CONTAINING RNA-BINDING PROTEIN QKI nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;RNA binding#GO:0003723 regulation of mRNA metabolic process#GO:1903311;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of mRNA processing#GO:0050684;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of mRNA splicing, via spliceosome#GO:0048024 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 RNA processing factor#PC00147;RNA splicing factor#PC00148 HUMAN|HGNC=24046|UniProtKB=Q969Q4 Q969Q4 ARL11 PTHR11711:SF172 ADP RIBOSYLATION FACTOR-RELATED ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 11 guanyl nucleotide binding#GO:0019001;ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;small molecule binding#GO:0036094;anion binding#GO:0043168;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;nucleotide binding#GO:0000166;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363 transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;protein transport#GO:0015031;intracellular protein localization#GO:0008104;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;macromolecule localization#GO:0033036;vesicle-mediated transport#GO:0016192 plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein#PC00020 HUMAN|HGNC=6875|UniProtKB=O15264 O15264 MAPK13 PTHR24055:SF107 MITOGEN-ACTIVATED PROTEIN KINASE MITOGEN-ACTIVATED PROTEIN KINASE 13 protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 Alzheimer disease-amyloid secretase pathway#P00003>MAPK#P00099;EGF receptor signaling pathway#P00018>p38#P00562;TGF-beta signaling pathway#P00052>P38#P01275;B cell activation#P00010>p38#P00384;FGF signaling pathway#P00021>p38#P00644;p38 MAPK pathway#P05918>p38delta#P06020;Interferon-gamma signaling pathway#P00035>Serine kinase#P00955;Integrin signalling pathway#P00034>ERK#P00907;Gonadotropin-releasing hormone receptor pathway#P06664>p38#P06831;p53 pathway feedback loops 2#P04398>p38 MAPK#P04648;Ras Pathway#P04393>p38#P04558;Oxidative stress response#P00046>p38#P01135 HUMAN|HGNC=11863|UniProtKB=O76062 O76062 TM7SF2 PTHR21257:SF59 DELTA(14)-STEROL REDUCTASE DELTA(14)-STEROL REDUCTASE TM7SF2 catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627 steroid biosynthetic process#GO:0006694;sterol metabolic process#GO:0016125;secondary alcohol biosynthetic process#GO:1902653;alcohol metabolic process#GO:0006066;metabolic process#GO:0008152;small molecule biosynthetic process#GO:0044283;cholesterol metabolic process#GO:0008203;lipid metabolic process#GO:0006629;lipid biosynthetic process#GO:0008610;cholesterol biosynthetic process#GO:0006695;sterol biosynthetic process#GO:0016126;steroid metabolic process#GO:0008202;biosynthetic process#GO:0009058;cellular process#GO:0009987;alcohol biosynthetic process#GO:0046165;small molecule metabolic process#GO:0044281;secondary alcohol metabolic process#GO:1902652;primary metabolic process#GO:0044238 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle envelope#GO:0031967;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;nuclear envelope#GO:0005635;endomembrane system#GO:0012505;nucleus#GO:0005634;organelle inner membrane#GO:0019866;membrane#GO:0016020;organelle membrane#GO:0031090;nuclear membrane#GO:0031965;nuclear inner membrane#GO:0005637;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 reductase#PC00198;oxidoreductase#PC00176 HUMAN|HGNC=24648|UniProtKB=Q9NY74 Q9NY74 ETAA1 PTHR16434:SF2 EWING'S TUMOR-ASSOCIATED ANTIGEN 1 ETAA1 EWING'S TUMOR-ASSOCIATED ANTIGEN 1 kinase activator activity#GO:0019209;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;protein serine/threonine kinase activator activity#GO:0043539;enzyme activator activity#GO:0008047;protein kinase activator activity#GO:0030295;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;protein kinase regulator activity#GO:0019887 nucleobase-containing compound metabolic process#GO:0006139;regulation of cell cycle process#GO:0010564;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;replication fork processing#GO:0031297;cellular process#GO:0009987;response to stress#GO:0006950;macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;regulation of response to stimulus#GO:0048583;metabolic process#GO:0008152;regulation of response to stress#GO:0080134;DNA metabolic process#GO:0006259;regulation of cell cycle#GO:0051726;regulation of cell communication#GO:0010646;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;DNA replication#GO:0006260;cellular response to stimulus#GO:0051716;regulation of cell cycle phase transition#GO:1901987;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of cellular response to stress#GO:0080135;DNA-templated DNA replication#GO:0006261;cellular response to stress#GO:0033554;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531 membraneless organelle#GO:0043228;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;intracellular organelle lumen#GO:0070013;nuclear replication fork#GO:0043596;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;chromosome#GO:0005694;organelle lumen#GO:0043233;replication fork#GO:0005657;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=30828|UniProtKB=Q96A98 Q96A98 PTH2 PTHR28585:SF1 TUBEROINFUNDIBULAR PEPTIDE OF 39 RESIDUES TUBEROINFUNDIBULAR PEPTIDE OF 39 RESIDUES HUMAN|HGNC=4369|UniProtKB=O60547 O60547 GMDS PTHR43715:SF1 GDP-MANNOSE 4,6-DEHYDRATASE GDP-MANNOSE 4,6 DEHYDRATASE lyase#PC00144;dehydratase#PC00091 Mannose metabolism#P02752>GDP-Mannose 4,6-dehydratase#P03015 HUMAN|HGNC=23617|UniProtKB=Q8WV83 Q8WV83 SLC35F5 PTHR23051:SF0 SOLUTE CARRIER FAMILY 35, MEMBER F5 SOLUTE CARRIER FAMILY 35 MEMBER F5 secondary carrier transporter#PC00258 HUMAN|HGNC=30026|UniProtKB=Q8TD55 Q8TD55 PLEKHO2 PTHR15871:SF2 PH DOMAIN-CONTAINING PROTEIN PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY O MEMBER 2 programmed cell death#GO:0012501;apoptotic process#GO:0006915;cell death#GO:0008219;cellular process#GO:0009987 HUMAN|HGNC=26363|UniProtKB=Q86YJ7 Q86YJ7 ANKRD13B PTHR12447:SF3 ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13 ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13B molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 biological regulation#GO:0065007;regulation of cellular component organization#GO:0051128;regulation of receptor-mediated endocytosis#GO:0048259;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;regulation of transport#GO:0051049;regulation of localization#GO:0032879;regulation of endocytosis#GO:0030100 late endosome#GO:0005770;endomembrane system#GO:0012505;plasma membrane#GO:0005886;cytoplasm#GO:0005737;membrane#GO:0016020;cell periphery#GO:0071944;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endosome#GO:0005768 scaffold/adaptor protein#PC00226 HUMAN|HGNC=16846|UniProtKB=Q15007 Q15007 WTAP PTHR15217:SF1 WILMS' TUMOR 1-ASSOCIATING PROTEIN PRE-MRNA-SPLICING REGULATOR WTAP enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 regulation of mRNA processing#GO:0050684;regulation of nucleobase-containing compound metabolic process#GO:0019219;biosynthetic process#GO:0009058;regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of RNA metabolic process#GO:0051252;gene expression#GO:0010467;RNA processing#GO:0006396;mRNA processing#GO:0006397;cellular process#GO:0009987;regulation of mRNA metabolic process#GO:1903311;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;mRNA metabolic process#GO:0016071;regulation of biological process#GO:0050789;RNA metabolic process#GO:0016070;regulation of alternative mRNA splicing, via spliceosome#GO:0000381;nucleic acid biosynthetic process#GO:0141187 nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;methyltransferase complex#GO:0034708;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=9303|UniProtKB=P30154 P30154 PPP2R1B PTHR10648:SF9 SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 65 KDA REGULATORY SUBUNIT A BETA ISOFORM protein complex scaffold activity#GO:0140378;structural molecule activity#GO:0005198 cellular process#GO:0009987;spindle assembly#GO:0051225;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;chromosome segregation#GO:0007059;microtubule-based process#GO:0007017;chromosome organization#GO:0051276;meiotic sister chromatid cohesion#GO:0051177;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;cell cycle process#GO:0022402;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;cell cycle#GO:0007049;organelle assembly#GO:0070925;sister chromatid cohesion#GO:0007062;microtubule cytoskeleton organization#GO:0000226 nucleus#GO:0005634;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;protein serine/threonine phosphatase complex#GO:0008287;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 phosphatase modulator#PC00184 FGF signaling pathway#P00021>PP2A#P00629 HUMAN|HGNC=4262|UniProtKB=P01242 P01242 GH2 PTHR11417:SF40 SOMATOTROPIN,PROLACTIN GROWTH HORMONE VARIANT molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;growth factor activity#GO:0008083;protein binding#GO:0005515;hormone activity#GO:0005179;molecular function activator activity#GO:0140677;cytokine receptor binding#GO:0005126;binding#GO:0005488;signaling receptor binding#GO:0005102;hormone receptor binding#GO:0051427 positive regulation of signaling#GO:0023056;response to oxygen-containing compound#GO:1901700;regulation of signaling#GO:0023051;cellular response to chemical stimulus#GO:0070887;animal gross anatomical part developmental process#GO:0160108;signaling#GO:0023052;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;cellular response to hormone stimulus#GO:0032870;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;animal organ development#GO:0048513;cell surface receptor signaling pathway#GO:0007166;response to chemical#GO:0042221;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987;response to hormone#GO:0009725;response to nitrogen compound#GO:1901698;cell communication#GO:0007154;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of receptor signaling pathway via JAK-STAT#GO:0046427;regulation of receptor signaling pathway via STAT#GO:1904892;regulation of cell communication#GO:0010646;cellular response to peptide hormone stimulus#GO:0071375;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;developmental process#GO:0032502;regulation of response to stimulus#GO:0048583;regulation of receptor signaling pathway via JAK-STAT#GO:0046425;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;response to peptide hormone#GO:0043434;positive regulation of response to stimulus#GO:0048584;cellular response to nitrogen compound#GO:1901699;positive regulation of cellular process#GO:0048522;response to nutrient levels#GO:0031667 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 peptide hormone#PC00179 HUMAN|HGNC=18371|UniProtKB=Q9BQT9 Q9BQT9 CLSTN3 PTHR14139:SF5 CALSYNTENIN CALSYNTENIN-3 binding#GO:0005488;cell adhesion molecule binding#GO:0050839;cell adhesion mediator activity#GO:0098631;protein binding#GO:0005515;cell-cell adhesion mediator activity#GO:0098632 regulation of cellular component organization#GO:0051128;positive regulation of nervous system development#GO:0051962;regulation of cellular process#GO:0050794;regulation of developmental process#GO:0050793;regulation of cellular component biogenesis#GO:0044087;regulation of biological process#GO:0050789;positive regulation of multicellular organismal process#GO:0051240;regulation of multicellular organismal development#GO:2000026;regulation of nervous system development#GO:0051960;regulation of synapse structure or activity#GO:0050803;regulation of biological quality#GO:0065008;positive regulation of cellular component organization#GO:0051130;cell adhesion#GO:0007155;regulation of synapse organization#GO:0050807;regulation of cell junction assembly#GO:1901888;regulation of synapse assembly#GO:0051963;positive regulation of cellular component biogenesis#GO:0044089;biological regulation#GO:0065007;regulation of multicellular organismal process#GO:0051239;homophilic cell-cell adhesion#GO:0007156;cell-cell adhesion#GO:0098609;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of synapse assembly#GO:0051965;positive regulation of developmental process#GO:0051094 postsynapse#GO:0098794;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;asymmetric synapse#GO:0032279;postsynaptic density#GO:0014069;postsynaptic specialization membrane#GO:0099634;postsynaptic membrane#GO:0045211;postsynaptic density membrane#GO:0098839;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;neuron to neuron synapse#GO:0098984;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;cell surface#GO:0009986;synaptic membrane#GO:0097060;cell junction#GO:0030054 membrane traffic protein#PC00150 HUMAN|HGNC=7675|UniProtKB=Q99608 Q99608 NDN PTHR11736:SF10 MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN NECDIN negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 scaffold/adaptor protein#PC00226 HUMAN|HGNC=25964|UniProtKB=Q9H6L5 Q9H6L5 RETREG1 PTHR28659:SF3 RETICULON-LIKE PROTEIN RETICULOPHAGY REGULATOR 1 process utilizing autophagic mechanism#GO:0061919;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of apoptotic process#GO:0042981;negative regulation of cellular process#GO:0048523;metabolic process#GO:0008152;cellular process#GO:0009987;negative regulation of programmed cell death#GO:0043069;autophagy#GO:0006914;reticulophagy#GO:0061709;negative regulation of neuron apoptotic process#GO:0043524;regulation of neuron apoptotic process#GO:0043523;macroautophagy#GO:0016236;biological regulation#GO:0065007;negative regulation of apoptotic process#GO:0043066 membrane#GO:0016020;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum membrane#GO:0005789;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=7690|UniProtKB=P56556 P56556 NDUFA6 PTHR12964:SF6 NADH-UBIQUINONE OXIDOREDUCTASE B14 SUBUNIT NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 6 transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;respiratory chain complex I#GO:0045271;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;respiratory chain complex#GO:0098803;oxidoreductase complex#GO:1990204;membrane#GO:0016020;membrane protein complex#GO:0098796 oxidoreductase#PC00176 HUMAN|HGNC=34528|UniProtKB=Q96B49 Q96B49 TOMM6 PTHR15527:SF0 MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM6 HOMOLOG MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM6 HOMOLOG intracellular organelle#GO:0043229;outer membrane#GO:0019867;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle envelope#GO:0031967;membrane protein complex#GO:0098796;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;mitochondrial outer membrane translocase complex#GO:0005742;mitochondrial outer membrane#GO:0005741;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane#GO:0016020;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;organelle outer membrane#GO:0031968;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;cytoplasm#GO:0005737 primary active transporter#PC00068;transporter#PC00227 HUMAN|HGNC=23155|UniProtKB=A0PJK1 A0PJK1 SLC5A10 PTHR11819:SF128 SOLUTE CARRIER FAMILY 5 SODIUM_MANNOSE COTRANSPORTER SLC5A10 solute:monoatomic cation symporter activity#GO:0015294;sugar transmembrane transporter activity#GO:0051119;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;active transmembrane transporter activity#GO:0022804;secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;solute:sodium symporter activity#GO:0015370;monoatomic cation transmembrane transporter activity#GO:0008324;carbohydrate transmembrane transporter activity#GO:0015144;symporter activity#GO:0015293 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258;transporter#PC00227 HUMAN|HGNC=18646|UniProtKB=Q53GQ0 Q53GQ0 HSD17B12 PTHR43899:SF14 RH59310P VERY-LONG-CHAIN 3-OXOACYL-COA REDUCTASE catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=751|UniProtKB=O95671 O95671 ASMTL PTHR43213:SF5 BIFUNCTIONAL DTTP/UTP PYROPHOSPHATASE/METHYLTRANSFERASE PROTEIN-RELATED BIFUNCTIONAL DTTP_UTP PYROPHOSPHATASE_METHYLTRANSFERASE PROTEIN-RELATED hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;nucleoside triphosphate diphosphatase activity#GO:0047429 HUMAN|HGNC=13054|UniProtKB=Q14202 Q14202 ZMYM3 PTHR45736:SF3 ZINC FINGER MYM-TYPE PROTEIN ZINC FINGER MYM-TYPE PROTEIN 3 zinc finger transcription factor#PC00244;DNA-binding transcription factor#PC00218 HUMAN|HGNC=26160|UniProtKB=Q8IYQ7 Q8IYQ7 THNSL1 PTHR43515:SF1 THREONINE SYNTHASE-LIKE 1 THREONINE SYNTHASE-LIKE 1 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 Threonine biosynthesis#P02781>Threonine synthase#P03190 HUMAN|HGNC=18151|UniProtKB=Q9NPJ8 Q9NPJ8 NXT2 PTHR12612:SF1 NUCLEAR TRANSPORT FACTOR 2 NTF2-RELATED EXPORT PROTEIN 2 nuclear transport#GO:0051169;nuclear export#GO:0051168;localization#GO:0051179;mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;nucleic acid transport#GO:0050657;nucleocytoplasmic transport#GO:0006913;mRNA transport#GO:0051028;establishment of RNA localization#GO:0051236;nucleobase-containing compound transport#GO:0015931;RNA localization#GO:0006403;RNA transport#GO:0050658;poly(A)+ mRNA export from nucleus#GO:0016973;macromolecule metabolic process#GO:0043170;establishment of localization#GO:0051234;transport#GO:0006810;metabolic process#GO:0008152;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;biosynthetic process#GO:0009058;gene expression#GO:0010467;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule localization#GO:0033036;nitrogen compound transport#GO:0071705 nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;nucleus#GO:0005634;organelle envelope#GO:0031967;membrane-bounded organelle#GO:0043227;nuclear pore#GO:0005643;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229 HUMAN|HGNC=14449|UniProtKB=Q9UHM6 Q9UHM6 OPN4 PTHR24240:SF72 OPSIN MELANOPSIN transmembrane signaling receptor activity#GO:0004888;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 detection of stimulus#GO:0051606;cellular process#GO:0009987;response to radiation#GO:0009314;cellular response to light stimulus#GO:0071482;signal transduction#GO:0007165;regulation of circadian rhythm#GO:0042752;biological regulation#GO:0065007;cellular response to abiotic stimulus#GO:0071214;response to external stimulus#GO:0009605;response to abiotic stimulus#GO:0009628;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cellular response to environmental stimulus#GO:0104004;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;response to light stimulus#GO:0009416;signaling#GO:0023052;cellular response to radiation#GO:0071478;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021 HUMAN|HGNC=10565|UniProtKB=O14828 O14828 SCAMP3 PTHR10687:SF6 SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN SCAMP SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN 3 transport#GO:0006810;localization#GO:0051179;secretion#GO:0046903;establishment of localization#GO:0051234;secretion by cell#GO:0032940;exocytosis#GO:0006887;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;export from cell#GO:0140352 bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;recycling endosome membrane#GO:0055038;recycling endosome#GO:0055037;Golgi apparatus#GO:0005794;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;trans-Golgi network membrane#GO:0032588;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;vesicle membrane#GO:0012506;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;endosome membrane#GO:0010008;endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular vesicle#GO:0097708 transfer/carrier protein#PC00219 HUMAN|HGNC=20584|UniProtKB=Q969S0 Q969S0 SLC35B4 PTHR10778:SF4 SOLUTE CARRIER FAMILY 35 MEMBER B NUCLEOTIDE SUGAR TRANSPORTER SLC35B4 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;nucleobase-containing compound transmembrane transporter activity#GO:0015932;organophosphate ester transmembrane transporter activity#GO:0015605;carbohydrate derivative transmembrane transporter activity#GO:1901505;nucleotide-sugar transmembrane transporter activity#GO:0005338 localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;transport#GO:0006810;nucleobase-containing compound transport#GO:0015931;organophosphate ester transport#GO:0015748;nucleotide-sugar transmembrane transport#GO:0015780;carbohydrate derivative transport#GO:1901264;cellular process#GO:0009987;nitrogen compound transport#GO:0071705 cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;endomembrane system#GO:0012505;cytoplasm#GO:0005737;endoplasmic reticulum membrane#GO:0005789;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;endoplasmic reticulum#GO:0005783;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588 secondary carrier transporter#PC00258 HUMAN|HGNC=26690|UniProtKB=Q8N960 Q8N960 CEP120 PTHR21574:SF0 CENTROSOMAL PROTEIN OF 120 KDA CENTROSOMAL PROTEIN OF 120 KDA microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;microtubule organizing center organization#GO:0031023;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;cell cycle#GO:0007049;organelle organization#GO:0006996;cellular process#GO:0009987;cell cycle process#GO:0022402;centrosome cycle#GO:0007098 microtubule organizing center#GO:0005815;centrosome#GO:0005813;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;microtubule cytoskeleton#GO:0015630;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232 HUMAN|HGNC=29919|UniProtKB=Q86Y26 Q86Y26 NUTM1 PTHR22879:SF13 NUT FAMILY MEMBER 1 NUT FAMILY MEMBER 1 HUMAN|HGNC=33832|UniProtKB=O75200 O75200 NPIPB7 PTHR15438:SF4 NUCLEAR PORE COMPLEX INTERACTING PROTEIN NUCLEAR PORE COMPLEX-INTERACTING PROTEIN FAMILY MEMBER B15-RELATED HUMAN|HGNC=14928|UniProtKB=Q9BZV1 Q9BZV1 UBXN6 PTHR23153:SF38 UBX-RELATED UBX DOMAIN-CONTAINING PROTEIN 6 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=13830|UniProtKB=Q9UHC6 Q9UHC6 CNTNAP2 PTHR15036:SF33 PIKACHURIN-LIKE PROTEIN CONTACTIN-ASSOCIATED PROTEIN-LIKE 2 signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;developmental process#GO:0032502;system process#GO:0003008;multicellular organism development#GO:0007275;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;nervous system process#GO:0050877;cognition#GO:0050890;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;cell communication#GO:0007154;anatomical structure development#GO:0048856 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;synapse#GO:0045202;cell junction#GO:0030054 cell adhesion molecule#PC00069 HUMAN|HGNC=39814|UniProtKB=P0DP73 P0DP73 DEFB130B PTHR20515:SF1 BETA-DEFENSIN BETA-DEFENSIN 130A-RELATED cytokine receptor binding#GO:0005126;signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515;chemokine receptor binding#GO:0042379;molecular function activator activity#GO:0140677;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;G protein-coupled receptor binding#GO:0001664;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772 cellular response to stimulus#GO:0051716;cell motility#GO:0048870;response to stimulus#GO:0050896;locomotion#GO:0040011;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;cellular response to chemical stimulus#GO:0070887;response to bacterium#GO:0009617;chemotaxis#GO:0006935;defense response to bacterium#GO:0042742;cell chemotaxis#GO:0060326;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;cellular process#GO:0009987;cell migration#GO:0016477;response to chemical#GO:0042221;taxis#GO:0042330;response to other organism#GO:0051707;defense response#GO:0006952;response to external stimulus#GO:0009605 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 antimicrobial response protein#PC00051;defense/immunity protein#PC00090 HUMAN|HGNC=9330|UniProtKB=O60828 O60828 PQBP1 PTHR21737:SF3 POLYGLUTAMINE BINDING PROTEIN 1/MARVEL MEMBRANE-ASSOCIATING DOMAIN CONTAINING 3 POLYGLUTAMINE-BINDING PROTEIN 1 binding#GO:0005488;ribonucleoprotein complex binding#GO:0043021;protein-containing complex binding#GO:0044877 RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;alternative mRNA splicing, via spliceosome#GO:0000380;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA splicing, via spliceosome#GO:0000398;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membraneless organelle#GO:0043228;cytoplasm#GO:0005737;nuclear body#GO:0016604;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 scaffold/adaptor protein#PC00226 HUMAN|HGNC=7134|UniProtKB=Q03111 Q03111 MLLT1 PTHR47827:SF4 AHD DOMAIN-CONTAINING PROTEIN PROTEIN ENL chromatin binding#GO:0003682;binding#GO:0005488 regulation of biological process#GO:0050789;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of DNA-templated transcription#GO:0006355;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;transcription elongation factor complex#GO:0008023;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;protein-containing complex#GO:0032991;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513 HUMAN|HGNC=489|UniProtKB=O95841 O95841 ANGPTL1 PTHR19143:SF25 FIBRINOGEN/TENASCIN/ANGIOPOEITIN ANGIOPOIETIN-RELATED PROTEIN 1 binding#GO:0005488;signaling receptor binding#GO:0005102;protein binding#GO:0005515 signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169 extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HUMAN|HGNC=1071|UniProtKB=P12644 P12644 BMP4 PTHR11848:SF165 TGF-BETA FAMILY BONE MORPHOGENETIC PROTEIN 4 molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;cytokine activity#GO:0005125;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545 enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;system development#GO:0048731;cellular response to stimulus#GO:0051716;BMP signaling pathway#GO:0030509;heart morphogenesis#GO:0003007;animal organ morphogenesis#GO:0009887;regulation of cellular process#GO:0050794;response to growth factor#GO:0070848;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;response to BMP#GO:0071772;developmental process#GO:0032502;positive regulation of cellular process#GO:0048522;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;animal gross anatomical part developmental process#GO:0160108;cellular response to growth factor stimulus#GO:0071363;positive regulation of cell population proliferation#GO:0008284;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;circulatory system development#GO:0072359;signaling#GO:0023052;cell surface receptor signaling pathway#GO:0007166;cellular response to BMP stimulus#GO:0071773;animal organ development#GO:0048513;multicellular organism development#GO:0007275;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;heart development#GO:0007507;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 growth factor#PC00112 Gonadotropin-releasing hormone receptor pathway#P06664>BMP2/4/15#P06817;TGF-beta signaling pathway#P00052>TGFbeta#P01286 HUMAN|HGNC=24801|UniProtKB=A4FU69 A4FU69 EFCAB5 PTHR46788:SF1 EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 5 EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 5 sperm motility#GO:0097722;cellular process#GO:0009987;cell motility#GO:0048870;reproductive process#GO:0022414 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;axoneme#GO:0005930;intracellular organelle#GO:0043229;cilium#GO:0005929;cytoskeleton#GO:0005856;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;organelle#GO:0043226;ciliary plasm#GO:0097014;cellular anatomical structure#GO:0110165 calcium-binding protein#PC00060;calmodulin-related#PC00061 HUMAN|Ensembl=ENSG00000278633.1|UniProtKB=A0AAG2T1P6 A0AAG2T1P6 PTHR15566:SF6 POM121-LIKE POM121-LIKE PROTEIN 1-RELATED HUMAN|HGNC=16488|UniProtKB=A6NIH7 A6NIH7 UNC119B PTHR12951:SF3 RETINAL PROTEIN 4 PROTEIN UNC-119 HOMOLOG B binding#GO:0005488;lipid binding#GO:0008289 establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;intracellular protein localization#GO:0008104;plasma membrane bounded cell projection assembly#GO:0120031;transport#GO:0006810;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;macromolecule localization#GO:0033036;cellular process#GO:0009987;cell projection assembly#GO:0030031;establishment of protein localization#GO:0045184;localization#GO:0051179;protein transport#GO:0015031;cilium organization#GO:0044782;organelle assembly#GO:0070925;cell projection organization#GO:0030030;cellular component organization#GO:0016043;cilium assembly#GO:0060271 cilium#GO:0005929;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 membrane traffic protein#PC00150 HUMAN|HGNC=7154|UniProtKB=P08473 P08473 MME PTHR11733:SF114 ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED NEPRILYSIN metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;metalloendopeptidase activity#GO:0004222;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096 proteolysis#GO:0006508;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;cellular process#GO:0009987;protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059;multicellular organismal process#GO:0032501;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 protease#PC00190;metalloprotease#PC00153 HUMAN|HGNC=10433|UniProtKB=O75676 O75676 RPS6KA4 PTHR24351:SF41 RIBOSOMAL PROTEIN S6 KINASE RIBOSOMAL PROTEIN S6 KINASE ALPHA-4 catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 regulation of DNA-templated transcription#GO:0006355;cell communication#GO:0007154;TORC1 signaling#GO:0038202;regulation of RNA metabolic process#GO:0051252;intracellular signal transduction#GO:0035556;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;signaling#GO:0023052;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of nucleobase-containing compound metabolic process#GO:0019219;TOR signaling#GO:0031929;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233 protein modifying enzyme#PC00260 PDGF signaling pathway#P00047>p90RSK#P01142;p38 MAPK pathway#P05918>MSK2#P06039;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>P90 RSK#P00888 HUMAN|HGNC=37180|UniProtKB=P0C7H9 P0C7H9 USP17L7 PTHR24006:SF651 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE INACTIVE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 17-LIKE PROTEIN 4-RELATED catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;cysteine-type deubiquitinase activity#GO:0004843;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005 regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of biological quality#GO:0065008;regulation of programmed cell death#GO:0043067;regulation of biological process#GO:0050789;regulation of protein stability#GO:0031647;regulation of apoptotic process#GO:0042981 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;cytosol#GO:0005829 cysteine protease#PC00081;protease#PC00190 HUMAN|HGNC=14097|UniProtKB=Q96LW9 Q96LW9 ZSCAN31 PTHR23226:SF132 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 31 transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=28970|UniProtKB=Q14156 Q14156 EFR3A PTHR12444:SF1 PROTEIN EFR3 HOMOLOG CMP44E PROTEIN EFR3 HOMOLOG A molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;protein-membrane adaptor activity#GO:0043495 localization within membrane#GO:0051668;protein localization to cell periphery#GO:1990778;intracellular protein localization#GO:0008104;localization#GO:0051179;cellular localization#GO:0051641;cellular process#GO:0009987;protein localization to membrane#GO:0072657;macromolecule localization#GO:0033036;protein localization to plasma membrane#GO:0072659 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HUMAN|HGNC=576|UniProtKB=O14727 O14727 APAF1 PTHR22845:SF5 APOPTOTIC PROTEASE-ACTIVATING FACTOR 1 APOPTOTIC PROTEASE-ACTIVATING FACTOR 1 FAS signaling pathway#P00020>Apaf1#P00597;Apoptosis signaling pathway#P00006>Apaf-1#P00301;Huntington disease#P00029>Apaf-1#P00768;p53 pathway#P00059>Apaf#G04703 HUMAN|HGNC=7744|UniProtKB=Q96PY6 Q96PY6 NEK1 PTHR44899:SF4 CAMK FAMILY PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE NEK1 catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;protein kinase activity#GO:0004672 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=37057|UniProtKB=Q8NAP8 Q8NAP8 ZBTB8B PTHR24394:SF33 ZINC FINGER PROTEIN ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 8B DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HUMAN|HGNC=16198|UniProtKB=Q9H1H1 Q9H1H1 GTSF1L PTHR21402:SF3 GAMETOCYTE SPECIFIC FACTOR 1-RELATED GAMETOCYTE-SPECIFIC FACTOR 1-LIKE HUMAN|HGNC=358|UniProtKB=O00170 O00170 AIP PTHR11242:SF3 ARYL HYDROCARBON RECEPTOR INTERACTING PROTEIN RELATED AH RECEPTOR-INTERACTING PROTEIN metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein modification process#GO:0036211;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;protein maturation#GO:0051604;protein folding#GO:0006457;biosynthetic process#GO:0009058 membrane#GO:0016020;cellular anatomical structure#GO:0110165 chaperone#PC00072 HUMAN|HGNC=6111|UniProtKB=Q13576 Q13576 IQGAP2 PTHR14149:SF12 RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF RAS GTPASE-ACTIVATING-LIKE PROTEIN IQGAP2 binding#GO:0005488;actin binding#GO:0003779;actin filament binding#GO:0051015;enzyme regulator activity#GO:0030234;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;molecular function activator activity#GO:0140677;calmodulin binding#GO:0005516;enzyme activator activity#GO:0008047;cytoskeletal protein binding#GO:0008092;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;molecular function regulator activity#GO:0098772 cellular process#GO:0009987;actomyosin contractile ring assembly#GO:0000915;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;actin filament organization#GO:0007015;mitotic cell cycle process#GO:1903047;cellular component organization or biogenesis#GO:0071840;cell cycle process#GO:0022402;cell division#GO:0051301;cellular component organization#GO:0016043;cell cycle#GO:0007049;actomyosin structure organization#GO:0031032;actin cytoskeleton organization#GO:0030036;mitotic cytokinesis#GO:0000281;mitotic cell cycle#GO:0000278;cytokinetic process#GO:0032506;actin filament-based process#GO:0030029;cytokinesis#GO:0000910;cortical cytoskeleton organization#GO:0030865;supramolecular fiber organization#GO:0097435;mitotic cytokinetic process#GO:1902410;cortical actin cytoskeleton organization#GO:0030866;cytoskeleton-dependent cytokinesis#GO:0061640 cell cortex#GO:0005938;cell periphery#GO:0071944;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 GTPase-activating protein#PC00257 HUMAN|HGNC=12419|UniProtKB=Q9NRH3 Q9NRH3 TUBG2 PTHR11588:SF79 TUBULIN TUBULIN GAMMA-2 CHAIN structural molecule activity#GO:0005198;nucleotide binding#GO:0000166;anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;binding#GO:0005488;structural constituent of cytoskeleton#GO:0005200;nucleoside phosphate binding#GO:1901265;guanyl nucleotide binding#GO:0019001;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561 microtubule polymerization or depolymerization#GO:0031109;mitotic sister chromatid segregation#GO:0000070;spindle organization#GO:0007051;mitotic cell cycle process#GO:1903047;chromosome organization#GO:0051276;microtubule polymerization#GO:0046785;cell cycle#GO:0007049;microtubule cytoskeleton organization involved in mitosis#GO:1902850;mitotic cell cycle#GO:0000278;reproductive process#GO:0022414;sexual reproduction#GO:0019953;organelle fission#GO:0048285;microtubule cytoskeleton organization#GO:0000226;supramolecular fiber organization#GO:0097435;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;meiotic cell cycle#GO:0051321;chromosome segregation#GO:0007059;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;protein-containing complex organization#GO:0043933;microtubule nucleation#GO:0007020;sister chromatid segregation#GO:0000819;nuclear chromosome segregation#GO:0098813;meiotic cell cycle process#GO:1903046;cellular component organization#GO:0016043;protein polymerization#GO:0051258;protein-containing complex assembly#GO:0065003;mitotic nuclear division#GO:0140014;cell cycle process#GO:0022402;mitotic spindle organization#GO:0007052;nuclear division#GO:0000280 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;supramolecular fiber#GO:0099512;microtubule#GO:0005874;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;nucleus#GO:0005634;microtubule cytoskeleton#GO:0015630;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;spindle#GO:0005819;microtubule organizing center#GO:0005815;centrosome#GO:0005813 tubulin#PC00228;cytoskeletal protein#PC00085 HUMAN|HGNC=17870|UniProtKB=Q9Y283 Q9Y283 INVS PTHR24178:SF2 MOLTING PROTEIN MLT-4 INVERSIN developmental process#GO:0032502;animal gross anatomical part developmental process#GO:0160108;intracellular protein localization#GO:0008104;system development#GO:0048731;animal organ development#GO:0048513;anatomical structure development#GO:0048856;localization#GO:0051179;multicellular organism development#GO:0007275;kidney development#GO:0001822;renal system development#GO:0072001;macromolecule localization#GO:0033036;protein localization to cilium#GO:0061512;protein localization to organelle#GO:0033365;multicellular organismal process#GO:0032501 cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;membrane-bounded organelle#GO:0043227;cilium#GO:0005929 HUMAN|HGNC=15833|UniProtKB=Q96KR7 Q96KR7 PHACTR3 PTHR12751:SF7 PHOSPHATASE AND ACTIN REGULATOR PHACTR PHOSPHATASE AND ACTIN REGULATOR 3 protein binding#GO:0005515;binding#GO:0005488;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092 cytoskeleton organization#GO:0007010;cellular component organization or biogenesis#GO:0071840;actin cytoskeleton organization#GO:0030036;actin filament-based process#GO:0030029;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043 phosphatase modulator#PC00184 HUMAN|HGNC=1338|UniProtKB=P21730 P21730 C5AR1 PTHR24225:SF29 CHEMOTACTIC RECEPTOR C5A ANAPHYLATOXIN CHEMOTACTIC RECEPTOR 1 molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;immune receptor activity#GO:0140375;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 activation of immune response#GO:0002253;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;positive regulation of immune system process#GO:0002684;immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166;immune response-activating signaling pathway#GO:0002757;regulation of biological process#GO:0050789;immune response-regulating signaling pathway#GO:0002764;cellular response to stimulus#GO:0051716;signaling#GO:0023052;immune response-activating cell surface receptor signaling pathway#GO:0002429;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of immune response#GO:0050776;phospholipase C-activating G protein-coupled receptor signaling pathway#GO:0007200;positive regulation of cytosolic calcium ion concentration#GO:0007204;G protein-coupled receptor signaling pathway#GO:0007186;immune system process#GO:0002376;regulation of biological quality#GO:0065008;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;plasma membrane#GO:0005886;membrane#GO:0016020;basal part of cell#GO:0045178;basolateral plasma membrane#GO:0016323;cell periphery#GO:0071944;basal plasma membrane#GO:0009925 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CHKR#P00854 HUMAN|HGNC=21029|UniProtKB=Q7Z4V0 Q7Z4V0 ZNF438 PTHR24408:SF23 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 438 transcription regulator activity#GO:0140110;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677 regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=7604|UniProtKB=Q9NQX4 Q9NQX4 MYO5C PTHR13140:SF313 MYOSIN UNCONVENTIONAL MYOSIN-VC cytoskeletal motor activity#GO:0003774;isomerase activity#GO:0016853;microfilament motor activity#GO:0000146;catalytic activity#GO:0003824;polypeptide conformation or assembly isomerase activity#GO:0120544;ATP-dependent activity#GO:0140657;macromolecular conformation isomerase activity#GO:0120543 actin cytoskeleton organization#GO:0030036;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;actin filament organization#GO:0007015;supramolecular fiber organization#GO:0097435;actin filament-based process#GO:0030029 membrane#GO:0016020;actin cytoskeleton#GO:0015629;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 actin binding motor protein#PC00040 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HUMAN|HGNC=25798|UniProtKB=Q0P6D6 Q0P6D6 CCDC15 PTHR14817:SF2 COILED-COIL DOMAIN-CONTAINING PROTEIN 15 COILED-COIL DOMAIN-CONTAINING PROTEIN 15 microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;centrosome#GO:0005813;microtubule organizing center#GO:0005815;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 HUMAN|HGNC=2555|UniProtKB=Q13620 Q13620 CUL4B PTHR11932:SF66 CULLIN CULLIN-4B enzyme binding#GO:0019899;protein complex scaffold activity#GO:0140378;ubiquitin-like protein ligase binding#GO:0044389;binding#GO:0005488;ubiquitin protein ligase binding#GO:0031625;structural molecule activity#GO:0005198;protein binding#GO:0005515 post-translational protein modification#GO:0043687;proteasomal protein catabolic process#GO:0010498;protein ubiquitination#GO:0016567;response to stress#GO:0006950;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;ubiquitin-dependent protein catabolic process#GO:0006511;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;DNA damage response#GO:0006974;catabolic process#GO:0009056;response to stimulus#GO:0050896;ribonucleoprotein complex biogenesis#GO:0022613;primary metabolic process#GO:0044238;protein modification process#GO:0036211;cellular response to stimulus#GO:0051716;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;ribosome biogenesis#GO:0042254;protein modification by small protein conjugation or removal#GO:0070647;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554 nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular membrane-bounded organelle#GO:0043231;transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;Cul4-RING E3 ubiquitin ligase complex#GO:0080008;ubiquitin ligase complex#GO:0000151;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=28631|UniProtKB=Q8N129 Q8N129 CNPY4 PTHR15382:SF3 CTG4A-RELATED PROTEIN CANOPY HOMOLOG 4 signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515 HUMAN|HGNC=18641|UniProtKB=Q8IX01 Q8IX01 SUGP2 PTHR23340:SF2 ARGININE/SERINE RICH SPLICING FACTOR SF4/14 SURP AND G-PATCH DOMAIN-CONTAINING PROTEIN 2 nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634 RNA splicing factor#PC00148;RNA processing factor#PC00147 HUMAN|HGNC=12470|UniProtKB=Q8TBC4 Q8TBC4 UBA3 PTHR10953:SF6 UBIQUITIN-ACTIVATING ENZYME E1 NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT ligase activity, forming carbon-sulfur bonds#GO:0016877;ATP-dependent activity#GO:0140657;thiosulfate-cyanide sulfurtransferase activity#GO:0004792;sulfurtransferase activity#GO:0016783;transferase activity, transferring sulphur-containing groups#GO:0016782;nucleotidyltransferase activity#GO:0016779;catalytic activity#GO:0003824;transferase activity#GO:0016740;ligase activity#GO:0016874;ubiquitin-like modifier activating enzyme activity#GO:0008641;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096 metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;protein modification process#GO:0036211;post-translational protein modification#GO:0043687 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 Ubiquitin proteasome pathway#P00060>E1#P01492 HUMAN|HGNC=10902|UniProtKB=Q13239 Q13239 SLA PTHR46037:SF5 PROTEIN ENHANCER OF SEVENLESS 2B SRC-LIKE-ADAPTER protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102;growth factor receptor binding#GO:0070851 cell communication#GO:0007154;regulation of intracellular signal transduction#GO:1902531;regulation of MAPK cascade#GO:0043408;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;COP9 signalosome#GO:0008180;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;cell periphery#GO:0071944;membrane-enclosed lumen#GO:0031974;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;protein-containing complex#GO:0032991 HUMAN|HGNC=17449|UniProtKB=Q9NYL5 Q9NYL5 CYP39A1 PTHR24304:SF2 CYTOCHROME P450 FAMILY 7 24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE steroid hydroxylase activity#GO:0008395;catalytic activity#GO:0003824;monooxygenase activity#GO:0004497;oxidoreductase activity#GO:0016491 oxidoreductase#PC00176;oxygenase#PC00177 HUMAN|HGNC=29957|UniProtKB=Q96A70 Q96A70 AZIN2 PTHR11482:SF4 ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE ANTIZYME INHIBITOR 2 ornithine decarboxylase activity#GO:0004586;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;lyase activity#GO:0016829;carbon-carbon lyase activity#GO:0016830;catalytic activity#GO:0003824;carboxy-lyase activity#GO:0016831;enzyme activator activity#GO:0008047;molecular function regulator activity#GO:0098772 regulation of protein catabolic process#GO:0042176;negative regulation of catabolic process#GO:0009895;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of protein metabolic process#GO:0051248;negative regulation of metabolic process#GO:0009892;regulation of transmembrane transport#GO:0034762;negative regulation of biological process#GO:0048519;polyamine metabolic process#GO:0006595;regulation of biological process#GO:0050789;regulation of catabolic process#GO:0009894;regulation of localization#GO:0032879;regulation of transport#GO:0051049;negative regulation of cellular process#GO:0048523;metabolic process#GO:0008152;polyamine biosynthetic process#GO:0006596;negative regulation of protein catabolic process#GO:0042177;biogenic amine metabolic process#GO:0006576;biological regulation#GO:0065007;biosynthetic process#GO:0009058;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;amine metabolic process#GO:0009308;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of transport#GO:0051050;negative regulation of macromolecule metabolic process#GO:0010605 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 decarboxylase#PC00089;metabolite interconversion enzyme#PC00262 Ornithine degradation#P02758>Ornithine decarboxylase#P03053 HUMAN|HGNC=25238|UniProtKB=Q8NHG7 Q8NHG7 SVIP PTHR35269:SF1 SMALL VCP/P97-INTERACTING PROTEIN SMALL VCP_P97-INTERACTING PROTEIN regulation of response to stimulus#GO:0048583;regulation of response to stress#GO:0080134;negative regulation of cellular process#GO:0048523;regulation of catabolic process#GO:0009894;positive regulation of catabolic process#GO:0009896;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;negative regulation of protein transport#GO:0051224;negative regulation of response to stimulus#GO:0048585;regulation of protein catabolic process#GO:0042176;regulation of establishment of protein localization#GO:0070201;negative regulation of catabolic process#GO:0009895;negative regulation of protein-containing complex assembly#GO:0031333;regulation of response to endoplasmic reticulum stress#GO:1905897;negative regulation of cellular component organization#GO:0051129;negative regulation of protein metabolic process#GO:0051248;negative regulation of proteasomal protein catabolic process#GO:1901799;regulation of ERAD pathway#GO:1904292;regulation of cellular process#GO:0050794;negative regulation of transport#GO:0051051;regulation of macromolecule metabolic process#GO:0060255;regulation of transport#GO:0051049;regulation of localization#GO:0032879;positive regulation of biological process#GO:0048518;regulation of protein metabolic process#GO:0051246;positive regulation of autophagy#GO:0010508;regulation of proteasomal protein catabolic process#GO:0061136;negative regulation of protein catabolic process#GO:0042177;regulation of protein localization#GO:0032880;regulation of cellular response to stress#GO:0080135;positive regulation of metabolic process#GO:0009893;regulation of biological process#GO:0050789;regulation of protein-containing complex assembly#GO:0043254;negative regulation of biological process#GO:0048519;regulation of autophagy#GO:0010506;regulation of cellular component biogenesis#GO:0044087;negative regulation of metabolic process#GO:0009892;regulation of protein transport#GO:0051223;regulation of cellular component organization#GO:0051128 endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=30281|UniProtKB=Q9NZL6 Q9NZL6 RGL1 PTHR23113:SF199 GUANINE NUCLEOTIDE EXCHANGE FACTOR RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE 1 GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 signaling#GO:0023052;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;Ras protein signal transduction#GO:0007265 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 guanyl-nucleotide exchange factor#PC00113 Ras Pathway#P04393>RalGDS#P04551 HUMAN|HGNC=23373|UniProtKB=Q9BV86 Q9BV86 NTMT1 PTHR12753:SF1 AD-003 - RELATED N-TERMINAL XAA-PRO-LYS N-METHYLTRANSFERASE 1 catalytic activity, acting on a protein#GO:0140096;protein methyltransferase activity#GO:0008276;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring one-carbon groups#GO:0016741;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757 organelle organization#GO:0006996;cell cycle#GO:0007049;cellular component organization#GO:0016043;cellular process#GO:0009987;cell cycle process#GO:0022402;cytoskeleton organization#GO:0007010;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226;microtubule-based process#GO:0007017 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 methyltransferase#PC00155;transferase#PC00220 HUMAN|HGNC=3695|UniProtKB=Q08830 Q08830 FGL1 PTHR19143:SF263 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN-LIKE PROTEIN 1 molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018 regulation of multicellular organismal process#GO:0051239;negative regulation of leukocyte activation#GO:0002695;negative regulation of lymphocyte activation#GO:0051250;biological regulation#GO:0065007;negative regulation of immune system process#GO:0002683;regulation of cell adhesion#GO:0030155;regulation of T cell activation#GO:0050863;negative regulation of cell adhesion#GO:0007162;negative regulation of cell-cell adhesion#GO:0022408;negative regulation of cell activation#GO:0050866;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;regulation of leukocyte cell-cell adhesion#GO:1903037;regulation of lymphocyte activation#GO:0051249;negative regulation of leukocyte cell-cell adhesion#GO:1903038;regulation of cell-cell adhesion#GO:0022407;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of cell activation#GO:0050865;regulation of biological process#GO:0050789;regulation of leukocyte activation#GO:0002694;negative regulation of biological process#GO:0048519;negative regulation of multicellular organismal process#GO:0051241;regulation of immune response#GO:0050776;negative regulation of T cell activation#GO:0050868 cellular anatomical structure#GO:0110165;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HUMAN|HGNC=32783|UniProtKB=O43361 O43361 ZNF749 PTHR24381:SF5 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 749 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=4250|UniProtKB=P19440 P19440 GGT1 PTHR11686:SF56 GAMMA GLUTAMYL TRANSPEPTIDASE GLUTATHIONE HYDROLASE 1 PROENZYME-RELATED peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 regulation of response to stimulus#GO:0048583;regulation of response to stress#GO:0080134;metabolic process#GO:0008152;sulfur compound catabolic process#GO:0044273;cellular process#GO:0009987;sulfur compound metabolic process#GO:0006790;biological regulation#GO:0065007;regulation of response to external stimulus#GO:0032101;regulation of defense response#GO:0031347;regulation of inflammatory response#GO:0050727;glutathione metabolic process#GO:0006749;peptide metabolic process#GO:0006518;regulation of biological process#GO:0050789;modified amino acid metabolic process#GO:0006575;regulation of immune system process#GO:0002682;catabolic process#GO:0009056 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 protease#PC00190;protein modifying enzyme#PC00260 HUMAN|HGNC=10857|UniProtKB=Q8IUQ4 Q8IUQ4 SIAH1 PTHR45877:SF7 E3 UBIQUITIN-PROTEIN LIGASE SIAH2 E3 UBIQUITIN-PROTEIN LIGASE SIAH1 catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein binding#GO:0005515;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;binding#GO:0005488;acyltransferase activity#GO:0016746;enzyme binding#GO:0019899;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787 catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234 Wnt signaling pathway#P00057>SIAH-1#P01433;p53 pathway#P00059>Siah#G04696;p53 pathway feedback loops 2#P04398>SIAH-1#P04660;p53 pathway feedback loops 2#P04398>SIAH-1#G04711 HUMAN|HGNC=26617|UniProtKB=Q8NB16 Q8NB16 MLKL PTHR44329:SF308 SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED MIXED LINEAGE KINASE DOMAIN-LIKE PROTEIN protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;cell communication#GO:0007154 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=20775|UniProtKB=Q9UJT0 Q9UJT0 TUBE1 PTHR11588:SF317 TUBULIN TUBULIN EPSILON CHAIN structural molecule activity#GO:0005198;nucleotide binding#GO:0000166;ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;guanyl nucleotide binding#GO:0019001;nucleoside phosphate binding#GO:1901265;structural constituent of cytoskeleton#GO:0005200;binding#GO:0005488;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525 cytoskeleton organization#GO:0007010;mitotic cell cycle#GO:0000278;cellular process#GO:0009987;organelle organization#GO:0006996;cell cycle#GO:0007049;cellular component organization#GO:0016043;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226 intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;microtubule cytoskeleton#GO:0015630;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 tubulin#PC00228;cytoskeletal protein#PC00085 HUMAN|HGNC=17043|UniProtKB=Q7RTP0 Q7RTP0 NIPA1 PTHR12570:SF17 DUF803 DOMAIN MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07070)-RELATED MAGNESIUM TRANSPORTER NIPA1 transport#GO:0006810;magnesium ion transport#GO:0015693;metal ion transport#GO:0030001;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;establishment of localization#GO:0051234 cellular anatomical structure#GO:0110165;membrane#GO:0016020 secondary carrier transporter#PC00258 HUMAN|HGNC=23471|UniProtKB=Q6P6B7 Q6P6B7 ANKRD16 PTHR24173:SF95 ANKYRIN REPEAT CONTAINING ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16 scaffold/adaptor protein#PC00226 HUMAN|HGNC=705|UniProtKB=O15144 O15144 ARPC2 PTHR12058:SF0 ARP2/3 COMPLEX 34 KDA SUBUNIT ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 2 structural molecule activity#GO:0005198;protein complex scaffold activity#GO:0140378 protein-containing complex organization#GO:0043933;actin filament organization#GO:0007015;cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;Arp2/3 complex-mediated actin nucleation#GO:0034314;actin polymerization or depolymerization#GO:0008154;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;supramolecular fiber organization#GO:0097435;cortical actin cytoskeleton organization#GO:0030866;actin filament-based process#GO:0030029;cortical cytoskeleton organization#GO:0030865;actin nucleation#GO:0045010;actin cytoskeleton organization#GO:0030036;actin filament polymerization#GO:0030041;protein-containing complex assembly#GO:0065003;protein polymerization#GO:0051258;cellular component organization#GO:0016043 intracellular organelle#GO:0043229;Arp2/3 protein complex#GO:0005885;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;nucleus#GO:0005634;actin cytoskeleton#GO:0015629;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Arp2/3#P00876;Cytoskeletal regulation by Rho GTPase#P00016>ARP2/3#P00511;Integrin signalling pathway#P00034>Arp2/3#P00912 HUMAN|HGNC=13234|UniProtKB=Q9H305 Q9H305 CDIP1 PTHR23292:SF7 LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR CELL DEATH-INDUCING P53-TARGET PROTEIN 1 metal ion binding#GO:0046872;cation binding#GO:0043169;zinc ion binding#GO:0008270;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;transition metal ion binding#GO:0046914 signal transduction#GO:0007165;cellular process#GO:0009987;intrinsic apoptotic signaling pathway in response to DNA damage#GO:0008630;response to stress#GO:0006950;biological regulation#GO:0065007;DNA damage response#GO:0006974;apoptotic signaling pathway#GO:0097190;regulation of biological process#GO:0050789;apoptotic process#GO:0006915;cell death#GO:0008219;cellular response to stimulus#GO:0051716;programmed cell death#GO:0012501;intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator#GO:0042771;signaling#GO:0023052;intrinsic apoptotic signaling pathway by p53 class mediator#GO:0072332;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cellular response to stress#GO:0033554;signal transduction by p53 class mediator#GO:0072331;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;intrinsic apoptotic signaling pathway#GO:0097193 cytoplasm#GO:0005737;vacuole#GO:0005773;cytoplasmic vesicle membrane#GO:0030659;late endosome#GO:0005770;endomembrane system#GO:0012505;lysosomal membrane#GO:0005765;nucleus#GO:0005634;membrane#GO:0016020;vesicle membrane#GO:0012506;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;vacuolar membrane#GO:0005774;lytic vacuole#GO:0000323;cytoplasmic side of membrane#GO:0098562;late endosome membrane#GO:0031902;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;lysosome#GO:0005764;vesicle#GO:0031982;intracellular vesicle#GO:0097708;lytic vacuole membrane#GO:0098852;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;side of membrane#GO:0098552;endosome membrane#GO:0010008;endosome#GO:0005768;intracellular organelle#GO:0043229 scaffold/adaptor protein#PC00226 HUMAN|HGNC=29291|UniProtKB=Q9P242 Q9P242 NYAP2 PTHR22633:SF1 NEURONAL TYROSINE-PHOSPHORYLATED PHOSPHOINOSITIDE-3-KINASE ADAPTER 2-RELATED NEURONAL TYROSINE-PHOSPHORYLATED PHOSPHOINOSITIDE-3-KINASE ADAPTER 2 nervous system development#GO:0007399;intracellular signaling cassette#GO:0141124;signal transduction#GO:0007165;cellular process#GO:0009987;neuron projection development#GO:0031175;cell projection morphogenesis#GO:0048858;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;signaling#GO:0023052;cell development#GO:0048468;response to stimulus#GO:0050896;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell morphogenesis#GO:0000902;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;neuron development#GO:0048666;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;multicellular organismal process#GO:0032501;phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0043491;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;system development#GO:0048731;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;anatomical structure development#GO:0048856 scaffold/adaptor protein#PC00226 HUMAN|HGNC=24255|UniProtKB=Q9Y3B9 Q9Y3B9 RRP15 PTHR13245:SF14 RRP15-LIKE PROTEIN RRP15-LIKE PROTEIN macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;maturation of LSU-rRNA#GO:0000470;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;maturation of 5.8S rRNA#GO:0000460;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;ribosomal large subunit biogenesis#GO:0042273;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070 HUMAN|HGNC=21750|UniProtKB=Q96L11 Q96L11 LLCFC1 PTHR37348:SF1 LLLL AND CFNLAS MOTIF-CONTAINING PROTEIN 1 SPERM-EGG FUSION PROTEIN LLCFC1 sexual reproduction#GO:0019953;multicellular organismal reproductive process#GO:0048609;single fertilization#GO:0007338;cellular process#GO:0009987;fusion of sperm to egg plasma membrane involved in single fertilization#GO:0007342;fertilization#GO:0009566;reproductive process#GO:0022414;cellular process involved in reproduction in multicellular organism#GO:0022412 HUMAN|HGNC=269|UniProtKB=P54922 P54922 ADPRH PTHR16222:SF26 ADP-RIBOSYLGLYCOHYDROLASE ADP-RIBOSYLHYDROLASE ARH1 catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;metabolic process#GO:0008152;primary metabolic process#GO:0044238;protein modification process#GO:0036211;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 hydrolase#PC00121 HUMAN|HGNC=17969|UniProtKB=A8MPY1 A8MPY1 GABRR3 PTHR18945:SF196 NEUROTRANSMITTER GATED ION CHANNEL GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT RHO-3 chloride transmembrane transporter activity#GO:0015108;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic ion channel activity#GO:0015276;molecular transducer activity#GO:0060089;monoatomic anion channel activity#GO:0005253;channel activity#GO:0015267;neurotransmitter receptor activity#GO:0030594;chloride channel activity#GO:0005254;transporter activity#GO:0005215;monoatomic anion transmembrane transporter activity#GO:0008509;monoatomic ion transmembrane transporter activity#GO:0015075;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion channel activity#GO:0005216;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;gated channel activity#GO:0022836 monoatomic anion transport#GO:0006820;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;anterograde trans-synaptic signaling#GO:0098916;signaling#GO:0023052;trans-synaptic signaling#GO:0099537;localization#GO:0051179;chloride transmembrane transport#GO:1902476;cell communication#GO:0007154;transmembrane transport#GO:0055085;inorganic anion transport#GO:0015698;monoatomic ion transport#GO:0006811;synaptic signaling#GO:0099536;cellular process#GO:0009987;monoatomic anion transmembrane transport#GO:0098656;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;chloride transport#GO:0006821;transport#GO:0006810;establishment of localization#GO:0051234 cell periphery#GO:0071944;membrane#GO:0016020;GABA-ergic synapse#GO:0098982;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;synapse#GO:0045202;signaling receptor complex#GO:0043235;cell junction#GO:0030054 ligand-gated ion channel#PC00141 HUMAN|HGNC=27113|UniProtKB=W5XKT8 W5XKT8 SPACA6 PTHR37366:SF1 SPERM ACROSOME MEMBRANE-ASSOCIATED PROTEIN 6 SPERM ACROSOME MEMBRANE-ASSOCIATED PROTEIN 6 sexual reproduction#GO:0019953;multicellular organismal reproductive process#GO:0048609;single fertilization#GO:0007338;cellular process#GO:0009987;fusion of sperm to egg plasma membrane involved in single fertilization#GO:0007342;reproductive process#GO:0022414;fertilization#GO:0009566;cellular process involved in reproduction in multicellular organism#GO:0022412 HUMAN|HGNC=11726|UniProtKB=Q99973 Q99973 TEP1 PTHR44791:SF1 TELOMERASE PROTEIN COMPONENT 1 TEP1 TELOMERASE PROTEIN COMPONENT 1 RNA binding#GO:0003723;RNA-directed DNA polymerase activity#GO:0003964;binding#GO:0005488;nucleic acid binding#GO:0003676;telomerase activity#GO:0003720;DNA polymerase activity#GO:0034061;catalytic activity, acting on DNA#GO:0140097;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640 nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;telomere organization#GO:0032200;chromosome organization#GO:0051276;telomere maintenance#GO:0000723;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;DNA recombination#GO:0006310;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;mitotic recombination#GO:0006312 organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 DNA metabolism protein#PC00009 HUMAN|HGNC=12403|UniProtKB=Q8WZ42 Q8WZ42 TTN PTHR14340:SF13 MICROFIBRIL-ASSOCIATED GLYCOPROTEIN 3 TITIN animal organ development#GO:0048513;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;anatomical structure formation involved in morphogenesis#GO:0048646;striated muscle cell differentiation#GO:0051146;cellular anatomical entity morphogenesis#GO:0032989;striated muscle tissue development#GO:0014706;heart development#GO:0007507;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;striated muscle cell development#GO:0055002;animal gross anatomical part developmental process#GO:0160108;cell differentiation#GO:0030154;circulatory system development#GO:0072359;cell development#GO:0048468;actomyosin structure organization#GO:0031032;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cardiac muscle tissue development#GO:0048738;cellular developmental process#GO:0048869;developmental process#GO:0032502;multicellular organismal process#GO:0032501;tissue development#GO:0009888;anatomical structure development#GO:0048856;system development#GO:0048731;supramolecular fiber organization#GO:0097435;muscle tissue development#GO:0060537;cellular component assembly involved in morphogenesis#GO:0010927;organelle assembly#GO:0070925;sarcomere organization#GO:0045214;actin filament-based process#GO:0030029;actin cytoskeleton organization#GO:0030036;muscle structure development#GO:0061061;muscle cell development#GO:0055001;muscle cell differentiation#GO:0042692;myofibril assembly#GO:0030239 intracellular organelle#GO:0043229;M band#GO:0031430;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membraneless organelle#GO:0043228;myofibril#GO:0030016;sarcomere#GO:0030017;contractile muscle fiber#GO:0043292;A band#GO:0031672;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;organelle#GO:0043226;supramolecular complex#GO:0099080 HUMAN|HGNC=5171|UniProtKB=P02790 P02790 HPX PTHR10201:SF136 MATRIX METALLOPROTEINASE HEMOPEXIN endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 porphyrin-containing compound metabolic process#GO:0006778;extracellular structure organization#GO:0043062;metabolic process#GO:0008152;tetrapyrrole metabolic process#GO:0033013;external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;pigment metabolic process#GO:0042440;cellular component organization#GO:0016043;heme metabolic process#GO:0042168;catabolic process#GO:0009056 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 HUMAN|HGNC=39038|UniProtKB=P63145 P63145 ERVK-24 PTHR40389:SF2 ENDOGENOUS RETROVIRUS GROUP K MEMBER 24 GAG POLYPROTEIN-RELATED ENDOGENOUS RETROVIRUS GROUP K MEMBER 24 GAG POLYPROTEIN-RELATED HUMAN|HGNC=51240|UniProtKB=A0JP26 A0JP26 POTEB3 PTHR24118:SF65 POTE ANKYRIN DOMAIN POTE ANKYRIN DOMAIN FAMILY MEMBER B-RELATED transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714;transcription regulator activity#GO:0140110 regulation of intracellular signal transduction#GO:1902531;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of non-canonical NF-kappaB signal transduction#GO:1901222;regulation of biological process#GO:0050789 membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 membrane traffic protein#PC00150 HUMAN|HGNC=1888|UniProtKB=Q9UFW8 Q9UFW8 CGGBP1 PTHR32344:SF1 U1-TYPE DOMAIN-CONTAINING PROTEIN U1-TYPE DOMAIN-CONTAINING PROTEIN regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=6472|UniProtKB=O00515 O00515 LAD1 PTHR12392:SF0 LADININ 1 LADININ-1 structural protein#PC00211 HUMAN|HGNC=8858|UniProtKB=P56589 P56589 PEX3 PTHR28080:SF1 PEROXISOMAL BIOGENESIS FACTOR 3 PEROXISOMAL BIOGENESIS FACTOR 3 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 cellular localization#GO:0051641;localization#GO:0051179;protein transport#GO:0015031;peroxisomal transport#GO:0043574;localization within membrane#GO:0051668;peroxisome organization#GO:0007031;protein localization to organelle#GO:0033365;cellular component organization#GO:0016043;protein localization to membrane#GO:0072657;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;establishment of protein localization to organelle#GO:0072594;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;transport#GO:0006810;intracellular protein transport#GO:0006886;organelle organization#GO:0006996;establishment of protein localization to membrane#GO:0090150;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;microbody#GO:0042579;peroxisome#GO:0005777;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;peroxisomal membrane#GO:0005778 HUMAN|HGNC=24788|UniProtKB=Q1L5Z9 Q1L5Z9 LONRF2 PTHR23327:SF5 RING FINGER PROTEIN 127 LON PEPTIDASE N-TERMINAL DOMAIN AND RING FINGER PROTEIN 2 ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 cellular component organization#GO:0016043;apoptotic process#GO:0006915;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell development#GO:0048468;animal gross anatomical part developmental process#GO:0160108;protein catabolic process#GO:0030163;generation of neurons#GO:0048699;neuron apoptotic process#GO:0051402;neuron development#GO:0048666;neuron projection development#GO:0031175;cellular process#GO:0009987;nervous system development#GO:0007399;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;neuron differentiation#GO:0030182;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;primary metabolic process#GO:0044238;programmed cell death#GO:0012501;cell death#GO:0008219;protein quality control for misfolded or incompletely synthesized proteins#GO:0006515;catabolic process#GO:0009056;anatomical structure development#GO:0048856;protein metabolic process#GO:0019538;system development#GO:0048731;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;developmental process#GO:0032502;macromolecule metabolic process#GO:0043170;cellular developmental process#GO:0048869;neurogenesis#GO:0022008 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=26725|UniProtKB=Q9P272 Q9P272 TRMT9B PTHR13069:SF36 ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8 TRNA METHYLTRANSFERASE 9B-RELATED tRNA methyltransferase activity#GO:0008175;catalytic activity, acting on RNA#GO:0140098;RNA methyltransferase activity#GO:0008173;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring one-carbon groups#GO:0016741;RNA binding#GO:0003723;catalytic activity, acting on a tRNA#GO:0140101;tRNA binding#GO:0000049;nucleic acid binding#GO:0003676;binding#GO:0005488;methyltransferase activity#GO:0008168 methylation#GO:0032259;RNA methylation#GO:0001510;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187;macromolecule methylation#GO:0043414;tRNA modification#GO:0006400;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;tRNA wobble base modification#GO:0002097;tRNA wobble uridine modification#GO:0002098;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;gene expression#GO:0010467;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;tRNA methylation#GO:0030488;macromolecule biosynthetic process#GO:0009059 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 HUMAN|HGNC=26440|UniProtKB=Q6GMR7 Q6GMR7 FAAH2 PTHR43372:SF4 FATTY-ACID AMIDE HYDROLASE FATTY-ACID AMIDE HYDROLASE 2 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HUMAN|HGNC=11295|UniProtKB=Q86TD4 Q86TD4 SRL PTHR43681:SF3 TRANSMEMBRANE GTPASE FZO SARCALUMENIN calcium ion transport#GO:0006816;monoatomic ion transport#GO:0006811;metal ion transport#GO:0030001;establishment of localization#GO:0051234;localization#GO:0051179;monoatomic cation transport#GO:0006812;transport#GO:0006810 G-protein#PC00020;protein-binding activity modulator#PC00095 HUMAN|HGNC=22880|UniProtKB=Q96JG8 Q96JG8 MAGED4 PTHR11736:SF37 MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN MELANOMA-ASSOCIATED ANTIGEN D4 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 scaffold/adaptor protein#PC00226 HUMAN|HGNC=5309|UniProtKB=O60921 O60921 HUS1 PTHR12900:SF4 MITOTIC AND DNA DAMAGE CHECKPOINT PROTEIN HUS1 CHECKPOINT PROTEIN HUS1 negative regulation of mitotic cell cycle phase transition#GO:1901991;signal transduction#GO:0007165;cellular process#GO:0009987;organelle organization#GO:0006996;negative regulation of cell cycle G2/M phase transition#GO:1902750;cellular component organization or biogenesis#GO:0071840;meiotic cell cycle#GO:0051321;DNA metabolic process#GO:0006259;regulation of cell cycle#GO:0051726;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;signal transduction in response to DNA damage#GO:0042770;cell cycle process#GO:0022402;double-strand break repair via homologous recombination#GO:0000724;negative regulation of biological process#GO:0048519;negative regulation of cell cycle phase transition#GO:1901988;mitotic intra-S DNA damage checkpoint signaling#GO:0031573;biological regulation#GO:0065007;mitotic cell cycle process#GO:1903047;chromosome organization#GO:0051276;macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;negative regulation of cellular process#GO:0048523;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;regulation of cell cycle phase transition#GO:1901987;cell cycle#GO:0007049;primary metabolic process#GO:0044238;telomere organization#GO:0032200;regulation of G2/M transition of mitotic cell cycle#GO:0010389;sexual reproduction#GO:0019953;regulation of cell cycle process#GO:0010564;cell cycle checkpoint signaling#GO:0000075;negative regulation of G2/M transition of mitotic cell cycle#GO:0010972;response to stress#GO:0006950;double-strand break repair#GO:0006302;DNA replication checkpoint signaling#GO:0000076;negative regulation of cell cycle#GO:0045786;DNA recombination#GO:0006310;metabolic process#GO:0008152;signaling#GO:0023052;mitotic DNA replication checkpoint signaling#GO:0033314;cellular component organization#GO:0016043;meiotic cell cycle process#GO:1903046;negative regulation of mitotic cell cycle#GO:0045930;regulation of mitotic cell cycle phase transition#GO:1901990;cellular response to stress#GO:0033554;nucleobase-containing compound metabolic process#GO:0006139;DNA damage checkpoint signaling#GO:0000077;mitotic G2/M transition checkpoint#GO:0044818;mitotic DNA integrity checkpoint signaling#GO:0044774;regulation of mitotic cell cycle#GO:0007346;regulation of cell cycle G2/M phase transition#GO:1902749;DNA integrity checkpoint signaling#GO:0031570;telomere maintenance#GO:0000723;negative regulation of cell cycle process#GO:0010948;DNA repair#GO:0006281;reproductive process#GO:0022414;mitotic cell cycle#GO:0000278;mitotic DNA damage checkpoint signaling#GO:0044773;mitotic cell cycle checkpoint signaling#GO:0007093;nucleic acid metabolic process#GO:0090304;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;recombinational repair#GO:0000725 membraneless organelle#GO:0043228;condensed nuclear chromosome#GO:0000794;nuclear protein-containing complex#GO:0140513;condensed chromosome#GO:0000793;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;site of double-strand break#GO:0035861;intracellular anatomical structure#GO:0005622;site of DNA damage#GO:0090734;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;organelle lumen#GO:0043233;chromosome#GO:0005694 DNA metabolism protein#PC00009 HUMAN|HGNC=19855|UniProtKB=Q8ND07 Q8ND07 BBOF1 PTHR14845:SF5 COILED-COIL DOMAIN-CONTAINING 166 BASAL BODY-ORIENTATION FACTOR 1 HUMAN|HGNC=28339|UniProtKB=Q8NEQ6 Q8NEQ6 SRARP PTHR38494:SF1 STEROID RECEPTOR-ASSOCIATED AND REGULATED PROTEIN STEROID RECEPTOR-ASSOCIATED AND REGULATED PROTEIN binding#GO:0005488;transcription factor binding#GO:0008134;nuclear receptor binding#GO:0016922;nuclear estrogen receptor binding#GO:0030331;RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629;protein binding#GO:0005515;DNA-binding transcription factor binding#GO:0140297 regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;positive regulation of intracellular signal transduction#GO:1902533;regulation of intracellular signal transduction#GO:1902531;positive regulation of signaling#GO:0023056;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;positive regulation of response to stimulus#GO:0048584 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=18186|UniProtKB=Q9NS66 Q9NS66 GPR173 PTHR19268:SF4 G PROTEIN-COUPLED RECEPTOR G PROTEIN-COUPLED RECEPTOR 173-RELATED transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=11854|UniProtKB=P41732 P41732 TSPAN7 PTHR19282:SF257 TETRASPANIN TETRASPANIN-7 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=33257|UniProtKB=Q6ZN06 Q6ZN06 ZNF813 PTHR24377:SF644 IP01015P-RELATED ZINC FINGER PROTEIN 813 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=7993|UniProtKB=Q9UHY1 Q9UHY1 NRBP1 PTHR13902:SF48 SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED NUCLEAR RECEPTOR-BINDING PROTEIN protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=8642|UniProtKB=Q96JT2 Q96JT2 SLC45A3 PTHR19432:SF37 SUGAR TRANSPORTER SOLUTE CARRIER FAMILY 45 MEMBER 3 monoatomic cation transmembrane transporter activity#GO:0008324;carbohydrate transmembrane transporter activity#GO:0015144;symporter activity#GO:0015293;solute:proton symporter activity#GO:0015295;active transmembrane transporter activity#GO:0022804;solute:monoatomic cation symporter activity#GO:0015294;monoatomic ion transmembrane transporter activity#GO:0015075;secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;proton transmembrane transporter activity#GO:0015078 cellular anatomical structure#GO:0110165;membrane#GO:0016020 secondary carrier transporter#PC00258 HUMAN|HGNC=5284|UniProtKB=P15516 P15516 HTN3 PTHR15057:SF0 STATHERIN HISTATIN-3 response to other organism#GO:0051707;defense response to other organism#GO:0098542;cellular process#GO:0009987;defense response to symbiont#GO:0140546;immune response#GO:0006955;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;defense response#GO:0006952;response to external stimulus#GO:0009605;humoral immune response#GO:0006959;antimicrobial humoral response#GO:0019730;cell killing#GO:0001906;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;immune system process#GO:0002376 intracellular organelle#GO:0043229;extracellular region#GO:0005576;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=22421|UniProtKB=Q9BRJ6 Q9BRJ6 CHLSN PTHR22306:SF2 CHROMOSOME 7 OPEN READING FRAME 50 PROTEIN CHOLESIN HUMAN|HGNC=18355|UniProtKB=Q8N0X4 Q8N0X4 CLYBL PTHR11105:SF0 CITRATE LYASE SUBUNIT BETA-RELATED CITRAMALYL-COA LYASE, MITOCHONDRIAL carbon-carbon lyase activity#GO:0016830;catalytic activity#GO:0003824;lyase activity#GO:0016829 regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of cellular process#GO:0050794 lyase#PC00144 Pyruvate metabolism#P02772>Citrate Lyase#P03137 HUMAN|HGNC=18247|UniProtKB=Q2TAY7 Q2TAY7 SMU1 PTHR22848:SF2 WD40 REPEAT PROTEIN WD40 REPEAT-CONTAINING PROTEIN SMU1 gene expression#GO:0010467;RNA biosynthetic process#GO:0032774;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;nucleic acid biosynthetic process#GO:0141187 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634;spliceosomal complex#GO:0005681;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;precatalytic spliceosome#GO:0071011;ribonucleoprotein complex#GO:1990904 HUMAN|HGNC=8002|UniProtKB=P54845 P54845 NRL PTHR10129:SF24 TRANSCRIPTION FACTOR MAF NEURAL RETINA-SPECIFIC LEUCINE ZIPPER PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 multicellular organism development#GO:0007275;animal organ development#GO:0048513;neuron differentiation#GO:0030182;nervous system development#GO:0007399;retina development in camera-type eye#GO:0060041;cellular process#GO:0009987;sensory system development#GO:0048880;eye development#GO:0001654;neuron development#GO:0048666;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;sensory organ morphogenesis#GO:0090596;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;developmental process#GO:0032502;sensory organ development#GO:0007423;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;camera-type eye morphogenesis#GO:0048593;regulation of macromolecule biosynthetic process#GO:0010556;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;camera-type eye development#GO:0043010;visual system development#GO:0150063;regulation of macromolecule metabolic process#GO:0060255;animal organ morphogenesis#GO:0009887;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 basic leucine zipper transcription factor#PC00056;DNA-binding transcription factor#PC00218 HUMAN|HGNC=25352|UniProtKB=Q8N1W2 Q8N1W2 ZNF710 PTHR24390:SF43 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 710 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA-binding transcription factor#PC00218;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=11846|UniProtKB=Q99442 Q99442 SEC62 PTHR12443:SF9 TRANSLOCATION PROTEIN SEC62 TRANSLOCATION PROTEIN SEC62 transmembrane protein transporter activity#GO:0008320;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 protein transmembrane transport#GO:0071806;intracellular protein transport#GO:0006886;transport#GO:0006810;protein targeting to membrane#GO:0006612;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;protein targeting to ER#GO:0045047;establishment of protein localization to organelle#GO:0072594;intracellular protein transmembrane transport#GO:0065002;establishment of localization#GO:0051234;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule localization#GO:0033036;establishment of protein localization to membrane#GO:0090150;establishment of protein localization to endoplasmic reticulum#GO:0072599;localization within membrane#GO:0051668;post-translational protein targeting to membrane, translocation#GO:0031204;protein transport#GO:0015031;localization#GO:0051179;transmembrane transport#GO:0055085;cellular localization#GO:0051641;post-translational protein targeting to endoplasmic reticulum membrane#GO:0006620;protein targeting#GO:0006605 intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 HUMAN|HGNC=10872|UniProtKB=Q9UNP4 Q9UNP4 ST3GAL5 PTHR13713:SF60 SIALYLTRANSFERASE LACTOSYLCERAMIDE ALPHA-2,3-SIALYLTRANSFERASE catalytic activity#GO:0003824;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;sialyltransferase activity#GO:0008373 primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;biosynthetic process#GO:0009058;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170 metabolite interconversion enzyme#PC00262;transferase#PC00220 HUMAN|HGNC=12398|UniProtKB=Q9UNY4 Q9UNY4 TTF2 PTHR45626:SF50 TRANSCRIPTION TERMINATION FACTOR 2-RELATED TRANSCRIPTION TERMINATION FACTOR 2 ATP-dependent activity#GO:0140657;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;catalytic activity, acting on DNA#GO:0140097;ATP-dependent activity, acting on DNA#GO:0008094 cellular response to stress#GO:0033554;DNA damage response#GO:0006974;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stress#GO:0006950;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound metabolic process#GO:0006139;response to stimulus#GO:0050896 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 Transcription regulation by bZIP transcription factor#P00055>TTF2#P01389 HUMAN|HGNC=19764|UniProtKB=Q5TA89 Q5TA89 HES5 PTHR10985:SF159 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED TRANSCRIPTION FACTOR HES-5 nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;regulation of biological process#GO:0050789;regulation of multicellular organismal development#GO:2000026;negative regulation of biological process#GO:0048519;signaling#GO:0023052;negative regulation of metabolic process#GO:0009892;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;neuron differentiation#GO:0030182;cell surface receptor signaling pathway#GO:0007166;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;anterior/posterior pattern specification#GO:0009952;multicellular organism development#GO:0007275;signal transduction#GO:0007165;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of multicellular organismal process#GO:0051239;nervous system development#GO:0007399;pattern specification process#GO:0007389;system development#GO:0048731;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;cell communication#GO:0007154;regulation of nervous system development#GO:0051960;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;cellular response to stimulus#GO:0051716;regulation of neurogenesis#GO:0050767;regulation of developmental process#GO:0050793;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;developmental process#GO:0032502;regulation of cell differentiation#GO:0045595;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;regulation of biosynthetic process#GO:0009889;Notch signaling pathway#GO:0007219;cellular developmental process#GO:0048869;negative regulation of macromolecule metabolic process#GO:0010605;regulation of cell development#GO:0060284;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;regionalization#GO:0003002;multicellular organismal process#GO:0032501 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 basic helix-loop-helix transcription factor#PC00055 Notch signaling pathway#P00045>E(spl)-C genes#G01541 HUMAN|HGNC=32312|UniProtKB=Q7L8S5 Q7L8S5 OTUD6A PTHR12419:SF13 OTU DOMAIN CONTAINING PROTEIN OTU DOMAIN-CONTAINING PROTEIN 6A catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;cysteine-type deubiquitinase activity#GO:0004843;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005 cysteine protease#PC00081 HUMAN|HGNC=9634|UniProtKB=Q93096 Q93096 PTP4A1 PTHR23339:SF55 TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE PROTEIN TYROSINE PHOSPHATASE TYPE IVA 1 phosphoprotein phosphatase activity#GO:0004721;protein tyrosine phosphatase activity#GO:0004725;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824 regulation of cell migration#GO:0030334;regulation of cell motility#GO:2000145;positive regulation of locomotion#GO:0040017;positive regulation of cell motility#GO:2000147;positive regulation of cell migration#GO:0030335;positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789;positive regulation of cellular process#GO:0048522;regulation of cellular process#GO:0050794;regulation of locomotion#GO:0040012;biological regulation#GO:0065007 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HUMAN|HGNC=29216|UniProtKB=Q2M1Z3 Q2M1Z3 ARHGAP31 PTHR15729:SF3 CDC42 GTPASE-ACTIVATING PROTEIN RHO GTPASE-ACTIVATING PROTEIN 31 enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;intracellular signaling cassette#GO:0141124;small GTPase-mediated signal transduction#GO:0007264;signaling#GO:0023052;biological regulation#GO:0065007;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 lamellipodium#GO:0030027;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cell leading edge#GO:0031252 protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HUMAN|HGNC=23927|UniProtKB=O14713 O14713 ITGB1BP1 PTHR32055:SF1 INTEGRIN BETA-1-BINDING PROTEIN 1 INTEGRIN BETA-1-BINDING PROTEIN 1 cell adhesion molecule binding#GO:0050839;binding#GO:0005488;signaling receptor binding#GO:0005102;integrin binding#GO:0005178;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 negative regulation of cellular process#GO:0048523;regulation of cell junction assembly#GO:1901888;regulation of cell-matrix adhesion#GO:0001952;negative regulation of cellular component organization#GO:0051129;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cell adhesion#GO:0030155;regulation of cellular component organization#GO:0051128;negative regulation of cell adhesion#GO:0007162;regulation of cellular component biogenesis#GO:0044087;biological regulation#GO:0065007;regulation of cell-substrate adhesion#GO:0010810 intracellular anatomical structure#GO:0005622;ruffle#GO:0001726;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;lamellipodium#GO:0030027;cell periphery#GO:0071944;cell leading edge#GO:0031252 HUMAN|HGNC=9533|UniProtKB=P25789 P25789 PSMA4 PTHR11599:SF13 PROTEASOME SUBUNIT ALPHA/BETA PROTEASOME SUBUNIT ALPHA TYPE-4 catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632 catalytic complex#GO:1902494;endopeptidase complex#GO:1905369;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;cytosol#GO:0005829;nucleus#GO:0005634;proteasome complex#GO:0000502;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;peptidase complex#GO:1905368;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 protease#PC00190;protein modifying enzyme#PC00260 Parkinson disease#P00049>20S proteasome#P01227 HUMAN|HGNC=3392|UniProtKB=P54762 P54762 EPHB1 PTHR46877:SF17 EPH RECEPTOR A5 EPHRIN TYPE-B RECEPTOR 1 transmembrane signaling receptor activity#GO:0004888;protein kinase activity#GO:0004672;molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;catalytic activity#GO:0003824;transmembrane receptor protein kinase activity#GO:0019199;signaling receptor activity#GO:0038023;catalytic activity, acting on a protein#GO:0140096 cellular developmental process#GO:0048869;neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;axon guidance#GO:0007411;axon development#GO:0061564;cell communication#GO:0007154;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;system development#GO:0048731;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;ephrin receptor signaling pathway#GO:0048013;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cell projection morphogenesis#GO:0048858;neuron differentiation#GO:0030182;cell surface receptor signaling pathway#GO:0007166;plasma membrane bounded cell projection morphogenesis#GO:0120039;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;neuron projection development#GO:0031175;signal transduction#GO:0007165;cellular process#GO:0009987;neuron development#GO:0048666;axonogenesis#GO:0007409;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;cell projection organization#GO:0030030;response to stimulus#GO:0050896;cell differentiation#GO:0030154;cell morphogenesis#GO:0000902;signaling#GO:0023052;cell development#GO:0048468;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789 plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;neuron projection#GO:0043005;membrane#GO:0016020;dendritic tree#GO:0097447;dendrite#GO:0030425 transmembrane signal receptor#PC00197 Angiogenesis#P00005>EphR#P00212 HUMAN|HGNC=21589|UniProtKB=Q8N3H0 Q8N3H0 TAFA2 PTHR31770:SF1 CHEMOKINE-LIKE PROTEIN TAFA FAMILY MEMBER CHEMOKINE-LIKE PROTEIN TAFA-2 receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 chemokine#PC00074;cytokine#PC00083 HUMAN|HGNC=12453|UniProtKB=Q01081 Q01081 U2AF1 PTHR12620:SF11 U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT SPLICING FACTOR U2AF 35 KDA SUBUNIT pre-mRNA binding#GO:0036002;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;spliceosomal complex#GO:0005681 RNA splicing factor#PC00148 HUMAN|HGNC=28973|UniProtKB=Q14165 Q14165 MLEC PTHR13460:SF0 FAMILY NOT NAMED MALECTIN carbohydrate binding#GO:0030246;binding#GO:0005488 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;catabolic process#GO:0009056;protein quality control for misfolded or incompletely synthesized proteins#GO:0006515;cellular process#GO:0009987;primary metabolic process#GO:0044238 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=15858|UniProtKB=Q9NVP4 Q9NVP4 DZANK1 PTHR16058:SF4 DOUBLE ZINC RIBBON AND ANKYRIN REPEAT-CONTAINING PROTEIN 1 DOUBLE ZINC RIBBON AND ANKYRIN REPEAT-CONTAINING PROTEIN 1 multicellular organismal process#GO:0032501;nervous system development#GO:0007399;sensory system development#GO:0048880;cellular process#GO:0009987;multicellular organism development#GO:0007275;animal organ development#GO:0048513;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;sensory organ development#GO:0007423;neuron differentiation#GO:0030182;developmental process#GO:0032502;cell differentiation#GO:0030154;animal organ morphogenesis#GO:0009887;sensory organ morphogenesis#GO:0090596;visual system development#GO:0150063;cell development#GO:0048468;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;system development#GO:0048731;neuron development#GO:0048666;eye development#GO:0001654;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699 HUMAN|HGNC=12917|UniProtKB=P52736 P52736 ZNF133 PTHR24381:SF119 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 133 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=17996|UniProtKB=Q8N159 Q8N159 NAGS PTHR23342:SF22 N-ACETYLGLUTAMATE SYNTHASE N-ACETYLGLUTAMATE SYNTHASE, MITOCHONDRIAL transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;phosphotransferase activity, carboxyl group as acceptor#GO:0016774;acyltransferase activity#GO:0016746 biosynthetic process#GO:0009058;arginine metabolic process#GO:0006525;amino acid metabolic process#GO:0006520;small molecule metabolic process#GO:0044281;proteinogenic amino acid metabolic process#GO:0170039;cellular process#GO:0009987;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;L-arginine biosynthetic process#GO:0006526;proteinogenic amino acid biosynthetic process#GO:0170038;small molecule biosynthetic process#GO:0044283;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;amino acid biosynthetic process#GO:0008652 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974 Arginine biosynthesis#P02728>N-acetylglutamate synthase#P02848 HUMAN|HGNC=28413|UniProtKB=Q96H35 Q96H35 RBM18 PTHR21245:SF2 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN RNA-BINDING PROTEIN 18-RELATED binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 RNA metabolism protein#PC00031 HUMAN|HGNC=30178|UniProtKB=Q9Y570 Q9Y570 PPME1 PTHR14189:SF0 PROTEIN PHOSPHATASE METHYLESTERASE-1 RELATED PROTEIN PHOSPHATASE METHYLESTERASE 1 hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788 protein modifying enzyme#PC00260 HUMAN|HGNC=4805|UniProtKB=Q16775 Q16775 HAGH PTHR11935:SF80 BETA LACTAMASE DOMAIN HYDROXYACYLGLUTATHIONE HYDROLASE, MITOCHONDRIAL thiolester hydrolase activity#GO:0016790;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;hydrolase activity#GO:0016787 glutathione metabolic process#GO:0006749;modified amino acid metabolic process#GO:0006575;sulfur compound metabolic process#GO:0006790;metabolic process#GO:0008152;cellular process#GO:0009987 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=1052|UniProtKB=O00499 O00499 BIN1 PTHR46514:SF4 AMPHIPHYSIN MYC BOX-DEPENDENT-INTERACTING PROTEIN 1 lipid binding#GO:0008289;protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;phospholipid binding#GO:0005543 cell junction#GO:0030054;secretory vesicle#GO:0099503;membrane#GO:0016020;presynapse#GO:0098793;cell periphery#GO:0071944;transport vesicle#GO:0030133;endomembrane system#GO:0012505;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular vesicle#GO:0097708;vesicle#GO:0031982;synaptic vesicle#GO:0008021;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=4909|UniProtKB=Q14526 Q14526 HIC1 PTHR24394:SF16 ZINC FINGER PROTEIN HYPERMETHYLATED IN CANCER 1 PROTEIN DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HUMAN|HGNC=2505|UniProtKB=P16410 P16410 CTLA4 PTHR11494:SF8 CYTOTOXIC T-LYMPHOCYTE PROTEIN CYTOTOXIC T-LYMPHOCYTE PROTEIN 4 regulation of cell development#GO:0060284;negative regulation of immune system process#GO:0002683;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;negative regulation of cell adhesion#GO:0007162;positive regulation of response to stimulus#GO:0048584;regulation of cell adhesion#GO:0030155;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;regulation of cell differentiation#GO:0045595;regulation of leukocyte cell-cell adhesion#GO:1903037;T cell receptor signaling pathway#GO:0050852;negative regulation of cellular process#GO:0048523;negative regulation of cell activation#GO:0050866;cellular response to stimulus#GO:0051716;negative regulation of multicellular organismal process#GO:0051241;negative regulation of leukocyte cell-cell adhesion#GO:1903038;regulation of developmental process#GO:0050793;immune response-activating cell surface receptor signaling pathway#GO:0002429;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of cell-cell adhesion#GO:0022407;regulation of immune response#GO:0050776;negative regulation of T cell activation#GO:0050868;regulation of hemopoiesis#GO:1903706;cell communication#GO:0007154;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;signal transduction#GO:0007165;cellular process#GO:0009987;B cell receptor signaling pathway#GO:0050853;positive regulation of immune system process#GO:0002684;negative regulation of lymphocyte activation#GO:0051250;regulation of multicellular organismal process#GO:0051239;negative regulation of leukocyte activation#GO:0002695;antigen receptor-mediated signaling pathway#GO:0050851;negative regulation of cell-cell adhesion#GO:0022408;regulation of T cell activation#GO:0050863;cell surface receptor signaling pathway#GO:0007166;immune response-activating signaling pathway#GO:0002757;regulation of biological process#GO:0050789;regulation of multicellular organismal development#GO:2000026;immune response-regulating signaling pathway#GO:0002764;regulation of cell activation#GO:0050865;negative regulation of biological process#GO:0048519;regulation of leukocyte activation#GO:0002694;signaling#GO:0023052;regulation of lymphocyte activation#GO:0051249;response to stimulus#GO:0050896;immune system process#GO:0002376 membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;plasma membrane#GO:0005886 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=25656|UniProtKB=Q9NUJ1 Q9NUJ1 ABHD10 PTHR16138:SF7 MYCOPHENOLIC ACID ACYL-GLUCURONIDE ESTERASE, MITOCHONDRIAL PALMITOYL-PROTEIN THIOESTERASE ABHD10, MITOCHONDRIAL hydrolase activity#GO:0016787;palmitoyl hydrolase activity#GO:0098599;thiolester hydrolase activity#GO:0016790;hydrolase activity, acting on glycosyl bonds#GO:0016798;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;hydrolase activity, acting on ester bonds#GO:0016788 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 esterase#PC00097;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=29969|UniProtKB=Q8TDB4 Q8TDB4 MGARP PTHR22910:SF6 PROTEIN MGARP PROTEIN MGARP organelle envelope#GO:0031967;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;outer membrane#GO:0019867;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;organelle outer membrane#GO:0031968;cytoplasm#GO:0005737;mitochondrial outer membrane#GO:0005741;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090 HUMAN|HGNC=24778|UniProtKB=A4D1S0 A4D1S0 KLRG2 PTHR47606:SF1 KILLER CELL LECTIN-LIKE RECEPTOR SUBFAMILY G MEMBER 2 KILLER CELL LECTIN-LIKE RECEPTOR SUBFAMILY G MEMBER 2 transmembrane signal receptor#PC00197 HUMAN|HGNC=1070|UniProtKB=P12645 P12645 BMP3 PTHR11848:SF144 TGF-BETA FAMILY BONE MORPHOGENETIC PROTEIN 3 receptor ligand activity#GO:0048018;cytokine activity#GO:0005125;signaling receptor regulator activity#GO:0030545;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546 cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;cell surface receptor signaling pathway#GO:0007166;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 growth factor#PC00112 TGF-beta signaling pathway#P00052>TGFbeta#P01286 HUMAN|HGNC=1176|UniProtKB=Q13405 Q13405 MRPL49 PTHR13477:SF0 MITOCHONDRIAL 39S RIBOSOMAL PROTEIN L49 LARGE RIBOSOMAL SUBUNIT PROTEIN ML49 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;ribosome#GO:0005840;mitochondrion#GO:0005739;mitochondrial ribosome#GO:0005761;organellar ribosome#GO:0000313;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;membraneless organelle#GO:0043228;mitochondrial large ribosomal subunit#GO:0005762 ribosomal protein#PC00202 HUMAN|HGNC=15605|UniProtKB=Q86WV1 Q86WV1 SKAP1 PTHR15129:SF1 SRC-ASSOCIATED ADAPTOR PROTEIN SRC KINASE-ASSOCIATED PHOSPHOPROTEIN 1 regulation of immune response#GO:0050776;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;positive regulation of cell adhesion#GO:0045785;regulation of immune system process#GO:0002682;regulation of cell-cell adhesion#GO:0022407;regulation of cellular process#GO:0050794;regulation of cell adhesion mediated by integrin#GO:0033628;immune response-activating cell surface receptor signaling pathway#GO:0002429;T cell receptor signaling pathway#GO:0050852;regulation of leukocyte cell-cell adhesion#GO:1903037;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;positive regulation of cellular process#GO:0048522;regulation of cell adhesion#GO:0030155;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;positive regulation of leukocyte cell-cell adhesion#GO:1903039;immune system process#GO:0002376;immune response-regulating signaling pathway#GO:0002764;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signaling#GO:0023052;cell surface receptor signaling pathway#GO:0007166;immune response-activating signaling pathway#GO:0002757;positive regulation of immune system process#GO:0002684;positive regulation of cell-cell adhesion#GO:0022409;cellular process#GO:0009987;activation of immune response#GO:0002253;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;antigen receptor-mediated signaling pathway#GO:0050851 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829;membrane#GO:0016020;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HUMAN|HGNC=2047|UniProtKB=O00501 O00501 CLDN5 PTHR12002:SF35 CLAUDIN CLAUDIN-5 cellular component organization or biogenesis#GO:0071840;cell-cell junction assembly#GO:0007043;cell-cell junction organization#GO:0045216;cell junction organization#GO:0034330;cellular component assembly#GO:0022607;cellular process#GO:0009987;cellular component organization#GO:0016043;cell junction assembly#GO:0034329;cellular component biogenesis#GO:0044085 cellular anatomical structure#GO:0110165;bicellular tight junction#GO:0005923;plasma membrane#GO:0005886;cell-cell junction#GO:0005911;membrane#GO:0016020;cell periphery#GO:0071944;tight junction#GO:0070160;cell junction#GO:0030054;anchoring junction#GO:0070161;apical junction complex#GO:0043296 tight junction#PC00214;cell junction protein#PC00070 HUMAN|HGNC=30041|UniProtKB=Q6P1J6 Q6P1J6 PLB1 PTHR21325:SF52 PHOSPHOLIPASE B, PLB1 PHOSPHOLIPASE B1, MEMBRANE-ASSOCIATED hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689;lipase activity#GO:0016298;phosphatidylcholine lysophospholipase A1 activity#GO:0004622;A2-type glycerophospholipase activity#GO:0004623;hydrolase activity, acting on ester bonds#GO:0016788;phospholipase activity#GO:0120569;catalytic activity#GO:0003824;glycerophospholipase activity#GO:0004620 phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;organophosphate metabolic process#GO:0019637;metabolic process#GO:0008152;cellular process#GO:0009987;lipid metabolic process#GO:0006629;phospholipid metabolic process#GO:0006644 apical part of cell#GO:0045177;cluster of actin-based cell projections#GO:0098862;cell projection membrane#GO:0031253;brush border#GO:0005903;cell periphery#GO:0071944;membrane#GO:0016020;apical plasma membrane#GO:0016324;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;cell projection#GO:0042995;brush border membrane#GO:0031526;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590 phospholipase#PC00186 HUMAN|HGNC=955|UniProtKB=Q9HBU1 Q9HBU1 BARX1 PTHR24330:SF12 HOMEOBOX PROTEIN BARH-LIKE HOMEOBOX PROTEIN BARH-LIKE 1 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=28605|UniProtKB=Q8N9S9 Q8N9S9 SNX31 PTHR12431:SF15 SORTING NEXIN 17 AND 27 SORTING NEXIN-31 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 vesicle-mediated transport#GO:0016192;endocytic recycling#GO:0032456;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle-mediated transport to the plasma membrane#GO:0098876;endosomal transport#GO:0016197;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;macromolecule metabolic process#GO:0043170;transport#GO:0006810;localization within membrane#GO:0051668;intracellular transport#GO:0046907;metabolic process#GO:0008152 intracellular organelle#GO:0043229;endosome#GO:0005768;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;vesicle#GO:0031982;intracellular vesicle#GO:0097708;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 scaffold/adaptor protein#PC00226 HUMAN|HGNC=24835|UniProtKB=Q7Z2K8 Q7Z2K8 GPRIN1 PTHR15718:SF7 G PROTEIN-REGULATED INDUCER OF NEURITE OUTGROWTH C-TERMINAL DOMAIN-CONTAINING PROTEIN G PROTEIN-REGULATED INDUCER OF NEURITE OUTGROWTH 1 neurogenesis#GO:0022008;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;developmental process#GO:0032502;neuron differentiation#GO:0030182;plasma membrane bounded cell projection organization#GO:0120036;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;cellular process#GO:0009987;neuron projection development#GO:0031175;system development#GO:0048731;neuron development#GO:0048666;anatomical structure development#GO:0048856;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cellular component organization#GO:0016043 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=2695|UniProtKB=Q16643 Q16643 DBN1 PTHR10829:SF1 CORTACTIN AND DREBRIN DREBRIN protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;actin binding#GO:0003779;actin filament binding#GO:0051015;cytoskeletal protein binding#GO:0008092 regulation of plasma membrane bounded cell projection organization#GO:0120035;neurogenesis#GO:0022008;regulation of cell projection organization#GO:0031344;positive regulation of developmental process#GO:0051094;regulation of cell differentiation#GO:0045595;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;positive regulation of cellular process#GO:0048522;regulation of cell development#GO:0060284;anatomical structure development#GO:0048856;regulation of synapse structure or activity#GO:0050803;synapse organization#GO:0050808;positive regulation of cell projection organization#GO:0031346;actin filament-based process#GO:0030029;cell junction organization#GO:0034330;regulation of cellular process#GO:0050794;regulation of dendrite morphogenesis#GO:0048814;regulation of neurogenesis#GO:0050767;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;regulation of anatomical structure morphogenesis#GO:0022603;regulation of anatomical structure size#GO:0090066;neuron differentiation#GO:0030182;positive regulation of cell differentiation#GO:0045597;nervous system development#GO:0007399;positive regulation of cell development#GO:0010720;organelle organization#GO:0006996;neuron projection development#GO:0031175;regulation of neuron projection development#GO:0010975;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;neuron development#GO:0048666;regulation of biological quality#GO:0065008;animal gross anatomical part developmental process#GO:0160108;regulation of actin filament length#GO:0030832;regulation of cellular component organization#GO:0051128;cell morphogenesis#GO:0000902;regulation of cellular component biogenesis#GO:0044087;cell development#GO:0048468;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;regulation of organelle organization#GO:0033043;positive regulation of multicellular organismal process#GO:0051240;regulation of postsynapse organization#GO:0099175;cellular developmental process#GO:0048869;regulation of actin filament-based process#GO:0032970;developmental process#GO:0032502;regulation of actin filament polymerization#GO:0030833;regulation of actin polymerization or depolymerization#GO:0008064;plasma membrane bounded cell projection organization#GO:0120036;regulation of actin filament organization#GO:0110053;regulation of nervous system development#GO:0051960;system development#GO:0048731;regulation of dendritic spine morphogenesis#GO:0061001;regulation of protein polymerization#GO:0032271;regulation of cytoskeleton organization#GO:0051493;actin cytoskeleton organization#GO:0030036;regulation of dendrite development#GO:0050773;regulation of developmental process#GO:0050793;postsynapse organization#GO:0099173;positive regulation of neurogenesis#GO:0050769;regulation of supramolecular fiber organization#GO:1902903;cell projection morphogenesis#GO:0048858;plasma membrane bounded cell projection morphogenesis#GO:0120039;cytoskeleton organization#GO:0007010;regulation of actin cytoskeleton organization#GO:0032956;regulation of multicellular organismal process#GO:0051239;positive regulation of neuron projection development#GO:0010976;positive regulation of cellular component organization#GO:0051130;generation of neurons#GO:0048699;regulation of synapse organization#GO:0050807;cell projection organization#GO:0030030;cell differentiation#GO:0030154;positive regulation of nervous system development#GO:0051962;cellular component organization#GO:0016043;regulation of protein-containing complex assembly#GO:0043254;regulation of cellular component size#GO:0032535;regulation of multicellular organismal development#GO:2000026 supramolecular fiber#GO:0099512;postsynaptic membrane#GO:0045211;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;cell projection#GO:0042995;cortical cytoskeleton#GO:0030863;postsynapse#GO:0098794;actin cytoskeleton#GO:0015629;cell cortex#GO:0005938;cell junction#GO:0030054;actin filament#GO:0005884;synaptic membrane#GO:0097060;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;cortical actin cytoskeleton#GO:0030864;intracellular membraneless organelle#GO:0043232;neuron projection#GO:0043005;intracellular anatomical structure#GO:0005622;site of polarized growth#GO:0030427;dendrite#GO:0030425;dendritic tree#GO:0097447;plasma membrane bounded cell projection#GO:0120025;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;plasma membrane region#GO:0098590;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HUMAN|HGNC=21650|UniProtKB=Q7Z5Y6 Q7Z5Y6 BMP8A PTHR11848:SF119 TGF-BETA FAMILY BONE MORPHOGENETIC PROTEIN 8A-RELATED signaling receptor regulator activity#GO:0030545;cytokine activity#GO:0005125;receptor ligand activity#GO:0048018;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 multicellular organism development#GO:0007275;animal organ development#GO:0048513;cellular response to BMP stimulus#GO:0071773;developmental process#GO:0032502;response to BMP#GO:0071772;cell surface receptor signaling pathway#GO:0007166;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;biological regulation#GO:0065007;heart development#GO:0007507;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;multicellular organismal process#GO:0032501;signal transduction#GO:0007165;cellular process#GO:0009987;system development#GO:0048731;cellular response to growth factor stimulus#GO:0071363;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;animal gross anatomical part developmental process#GO:0160108;signaling#GO:0023052;response to stimulus#GO:0050896;response to growth factor#GO:0070848;circulatory system development#GO:0072359;cellular response to endogenous stimulus#GO:0071495;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;BMP signaling pathway#GO:0030509;response to endogenous stimulus#GO:0009719 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 growth factor#PC00112 TGF-beta signaling pathway#P00052>TGFbeta#P01286 HUMAN|HGNC=33834|UniProtKB=Q6ZN32 Q6ZN32 ETV3L PTHR11849:SF306 ETS ETS TRANSLOCATION VARIANT 3-LIKE PROTEIN DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;winged helix/forkhead transcription factor#PC00246 PDGF signaling pathway#P00047>Ets#P01167 HUMAN|HGNC=4320|UniProtKB=P10075 P10075 GLI4 PTHR24388:SF112 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 281-RELATED transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=6518|UniProtKB=Q14739 Q14739 LBR PTHR21257:SF55 DELTA(14)-STEROL REDUCTASE DELTA(14)-STEROL REDUCTASE LBR oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 biosynthetic process#GO:0009058;sterol biosynthetic process#GO:0016126;steroid metabolic process#GO:0008202;cholesterol biosynthetic process#GO:0006695;lipid biosynthetic process#GO:0008610;alcohol biosynthetic process#GO:0046165;cellular process#GO:0009987;secondary alcohol biosynthetic process#GO:1902653;sterol metabolic process#GO:0016125;steroid biosynthetic process#GO:0006694;lipid metabolic process#GO:0006629;cholesterol metabolic process#GO:0008203;small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152;alcohol metabolic process#GO:0006066;secondary alcohol metabolic process#GO:1902652;small molecule metabolic process#GO:0044281;primary metabolic process#GO:0044238 membrane#GO:0016020;nucleus#GO:0005634;organelle inner membrane#GO:0019866;endomembrane system#GO:0012505;nuclear envelope#GO:0005635;cytoplasm#GO:0005737;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;nuclear inner membrane#GO:0005637;nuclear membrane#GO:0031965;organelle membrane#GO:0031090;organelle envelope#GO:0031967;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 reductase#PC00198;oxidoreductase#PC00176 HUMAN|HGNC=144|UniProtKB=P63261 P63261 ACTG1 PTHR11937:SF575 ACTIN ACTIN, CYTOPLASMIC 2 structural constituent of synapse#GO:0098918;structural molecule activity#GO:0005198;structural constituent of cytoskeleton#GO:0005200 actin filament#GO:0005884;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;actin cytoskeleton#GO:0015629;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;organelle#GO:0043226 actin and actin related protein#PC00039 Nicotinic acetylcholine receptor signaling pathway#P00044>Actin#P01090;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>F-actin#P00858;Huntington disease#P00029>Actin#P00807;Integrin signalling pathway#P00034>Actin#P00944;Wnt signaling pathway#P00057>NFAT Target Genes#G01559;Cadherin signaling pathway#P00012>F-actin#P00470;Cytoskeletal regulation by Rho GTPase#P00016>Actin#P00512;Alzheimer disease-presenilin pathway#P00004>actin#P00114 HUMAN|HGNC=17447|UniProtKB=O94985 O94985 CLSTN1 PTHR14139:SF4 CALSYNTENIN CALSYNTENIN-1 cell-cell adhesion mediator activity#GO:0098632;protein binding#GO:0005515;cell adhesion mediator activity#GO:0098631;cell adhesion molecule binding#GO:0050839;binding#GO:0005488 regulation of cellular component organization#GO:0051128;positive regulation of nervous system development#GO:0051962;regulation of cellular process#GO:0050794;regulation of developmental process#GO:0050793;regulation of cellular component biogenesis#GO:0044087;regulation of biological process#GO:0050789;positive regulation of multicellular organismal process#GO:0051240;regulation of multicellular organismal development#GO:2000026;regulation of nervous system development#GO:0051960;regulation of synapse structure or activity#GO:0050803;regulation of biological quality#GO:0065008;positive regulation of cellular component organization#GO:0051130;cell adhesion#GO:0007155;regulation of synapse organization#GO:0050807;regulation of cell junction assembly#GO:1901888;regulation of synapse assembly#GO:0051963;positive regulation of cellular component biogenesis#GO:0044089;biological regulation#GO:0065007;regulation of multicellular organismal process#GO:0051239;homophilic cell-cell adhesion#GO:0007156;cell-cell adhesion#GO:0098609;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of synapse assembly#GO:0051965;positive regulation of developmental process#GO:0051094 synaptic membrane#GO:0097060;cell junction#GO:0030054;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;neuron to neuron synapse#GO:0098984;cell surface#GO:0009986;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;postsynaptic density#GO:0014069;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;postsynaptic density membrane#GO:0098839;postsynapse#GO:0098794;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;asymmetric synapse#GO:0032279 membrane traffic protein#PC00150 HUMAN|HGNC=4576|UniProtKB=O43424 O43424 GRID2 PTHR18966:SF109 IONOTROPIC GLUTAMATE RECEPTOR GLUTAMATE RECEPTOR IONOTROPIC, DELTA-2 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;dicarboxylic acid transmembrane transporter activity#GO:0005310;ligand-gated channel activity#GO:0022834;glutamate receptor activity#GO:0008066;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;molecular transducer activity#GO:0060089;channel activity#GO:0015267;carboxylic acid transmembrane transporter activity#GO:0046943;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic ion transmembrane transporter activity#GO:0015075;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion channel activity#GO:0005216;signaling receptor activity#GO:0038023;neurotransmitter receptor activity#GO:0030594;amino acid transmembrane transporter activity#GO:0015171;transporter activity#GO:0005215;transmembrane signaling receptor activity#GO:0004888;gated channel activity#GO:0022836 regulation of signaling#GO:0023051;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;signaling#GO:0023052;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;cellular process#GO:0009987;synaptic signaling#GO:0099536;biological regulation#GO:0065007;synaptic transmission, glutamatergic#GO:0035249;cell-cell signaling#GO:0007267;regulation of trans-synaptic signaling#GO:0099177 postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;neuron spine#GO:0044309;postsynapse#GO:0098794;dendritic spine#GO:0043197;cell junction#GO:0030054;transporter complex#GO:1990351;synaptic membrane#GO:0097060;protein-containing complex#GO:0032991;neuron projection#GO:0043005;transmembrane transporter complex#GO:1902495;postsynaptic density membrane#GO:0098839;dendrite#GO:0030425;dendritic tree#GO:0097447;postsynaptic density#GO:0014069;asymmetric synapse#GO:0032279;plasma membrane bounded cell projection#GO:0120025;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;signaling receptor complex#GO:0043235;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;monoatomic ion channel complex#GO:0034702;neuron to neuron synapse#GO:0098984;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=19160|UniProtKB=Q9H6R6 Q9H6R6 ZDHHC6 PTHR22883:SF23 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE ZDHHC6 catalytic activity, acting on a protein#GO:0140096;palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740 cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of protein localization to membrane#GO:0090150;protein targeting#GO:0006605;localization within membrane#GO:0051668;protein targeting to membrane#GO:0006612;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 protein modifying enzyme#PC00260 HUMAN|HGNC=43|UniProtKB=Q03518 Q03518 TAP1 PTHR24221:SF249 ATP-BINDING CASSETTE SUB-FAMILY B ANTIGEN PEPTIDE TRANSPORTER 1 active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;protein binding#GO:0005515;binding#GO:0005488;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626 localization#GO:0051179;establishment of localization#GO:0051234;antigen processing and presentation#GO:0019882;transmembrane transport#GO:0055085;transport#GO:0006810;cellular process#GO:0009987;immune system process#GO:0002376 membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;membrane protein complex#GO:0098796;endoplasmic reticulum protein-containing complex#GO:0140534;organelle membrane#GO:0031090;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;membrane#GO:0016020 ATP-binding cassette (ABC) transporter#PC00003 HUMAN|HGNC=25947|UniProtKB=Q6TFL4 Q6TFL4 KLHL24 PTHR24412:SF215 KELCH PROTEIN KELCH-LIKE PROTEIN 24 enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;cullin-RING ubiquitin ligase complex#GO:0031461;catalytic complex#GO:1902494;transferase complex#GO:1990234;ubiquitin ligase complex#GO:0000151;Cul3-RING ubiquitin ligase complex#GO:0031463;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HUMAN|Ensembl=ENSG00000288336.1|UniProtKB=A0AAG2TVC3 A0AAG2TVC3 PTHR23331:SF5 CXYORF1 WAS PROTEIN FAMILY HOMOLOG 2-RELATED cellular component organization#GO:0016043;actin nucleation#GO:0045010;actin cytoskeleton organization#GO:0030036;endocytic recycling#GO:0032456;cytosolic transport#GO:0016482;export from cell#GO:0140352;actin filament-based process#GO:0030029;localization within membrane#GO:0051668;cellular localization#GO:0051641;secretion#GO:0046903;localization#GO:0051179;supramolecular fiber organization#GO:0097435;secretion by cell#GO:0032940;retrograde transport, endosome to Golgi#GO:0042147;organelle organization#GO:0006996;cellular process#GO:0009987;Arp2/3 complex-mediated actin nucleation#GO:0034314;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;cytoskeleton organization#GO:0007010;intracellular transport#GO:0046907;transport#GO:0006810;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;endosomal transport#GO:0016197;actin filament organization#GO:0007015;exocytosis#GO:0006887;vesicle-mediated transport to the plasma membrane#GO:0098876 vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endosome#GO:0005768;recycling endosome#GO:0055037;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HUMAN|HGNC=21109|UniProtKB=Q96EK7 Q96EK7 FAM120B PTHR15976:SF17 CONSTITUTIVE COACTIVATOR OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA CONSTITUTIVE COACTIVATOR OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;intracellular receptor signaling pathway#GO:0030522;biological regulation#GO:0065007;signaling#GO:0023052;nuclear receptor-mediated signaling pathway#GO:0141193;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=27648|UniProtKB=Q5T0L3 Q5T0L3 SPATA46 PTHR33517:SF4 PROTEIN FAM170B-RELATED SPERMATOGENESIS-ASSOCIATED PROTEIN 46 sexual reproduction#GO:0019953;reproductive process#GO:0022414;fertilization#GO:0009566 membrane-bounded organelle#GO:0043227;nuclear membrane#GO:0031965;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;membrane#GO:0016020;nucleus#GO:0005634 HUMAN|HGNC=12347|UniProtKB=Q9Y4A5 Q9Y4A5 TRRAP PTHR11139:SF1 ATAXIA TELANGIECTASIA MUTATED ATM -RELATED TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674 regulation of nucleobase-containing compound metabolic process#GO:0019219;chromatin organization#GO:0006325;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;response to stress#GO:0006950;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;DNA damage response#GO:0006974;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;chromatin remodeling#GO:0006338;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;cellular response to stress#GO:0033554 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;SAGA-type complex#GO:0070461;intracellular anatomical structure#GO:0005622;acetyltransferase complex#GO:1902493;membrane-bounded organelle#GO:0043227;protein acetyltransferase complex#GO:0031248;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;H4 histone acetyltransferase complex#GO:1902562;NuA4 histone acetyltransferase complex#GO:0035267;intracellular membraneless organelle#GO:0043232;peptidase complex#GO:1905368;SAGA complex#GO:0000124;chromatin#GO:0000785;nucleus#GO:0005634;membraneless organelle#GO:0043228;intracellular protein-containing complex#GO:0140535;histone acetyltransferase complex#GO:0000123;transferase complex#GO:1990234 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=29421|UniProtKB=Q8TF27 Q8TF27 AGAP11 PTHR45819:SF8 CENTAURIN-GAMMA-1A ARF-GAP WITH GTPASE, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 11 pyrophosphatase activity#GO:0016462;enzyme activator activity#GO:0008047;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;molecular function regulator activity#GO:0098772;ribonucleoside triphosphate phosphatase activity#GO:0017111;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity#GO:0016787;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677 GTPase-activating protein#PC00257;G-protein modulator#PC00022 HUMAN|HGNC=18167|UniProtKB=Q9NZW5 Q9NZW5 PALS2 PTHR23122:SF45 MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK PROTEIN PALS2 cell periphery#GO:0071944;cell-cell junction#GO:0005911;membrane#GO:0016020;plasma membrane#GO:0005886;anchoring junction#GO:0070161;cell junction#GO:0030054;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=32488|UniProtKB=Q5FYA8 Q5FYA8 ARSH PTHR42693:SF16 ARYLSULFATASE FAMILY MEMBER ARYLSULFATASE H catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787 hydrolase#PC00121 HUMAN|HGNC=19762|UniProtKB=Q8IX07 Q8IX07 ZFPM1 PTHR12958:SF4 FRIEND OF GATA2-RELATED ZINC FINGER PROTEIN ZFPM1 transcription factor binding#GO:0008134;transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712;DNA-binding transcription factor binding#GO:0140297;RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629;protein binding#GO:0005515;transcription regulator activity#GO:0140110;binding#GO:0005488 negative regulation of metabolic process#GO:0009892;cell development#GO:0048468;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;circulatory system development#GO:0072359;myeloid cell differentiation#GO:0030099;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;negative regulation of DNA-templated transcription#GO:0045892;immune system process#GO:0002376;animal gross anatomical part developmental process#GO:0160108;positive regulation of macromolecule metabolic process#GO:0010604;heart development#GO:0007507;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;multicellular organism development#GO:0007275;animal organ development#GO:0048513;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;positive regulation of transcription by RNA polymerase II#GO:0045944;homeostatic process#GO:0042592;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;system development#GO:0048731;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;erythrocyte differentiation#GO:0030218;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;homeostasis of number of cells#GO:0048872;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;hemopoiesis#GO:0030097;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;positive regulation of DNA-templated transcription#GO:0045893;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;multicellular organismal-level homeostasis#GO:0048871;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HUMAN|HGNC=16987|UniProtKB=Q9Y2Z0 Q9Y2Z0 SUGT1 PTHR45862:SF1 PROTEIN SGT1 HOMOLOG PROTEIN SGT1 HOMOLOG HUMAN|HGNC=28415|UniProtKB=Q5VXH5 Q5VXH5 PRAMEF7 PTHR14224:SF30 SIMILAR TO PREFERENTIALLY EXPRESSED ANTIGEN IN MELANOMA-LIKE 3 PRAME FAMILY MEMBER 7-RELATED molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;enzyme-substrate adaptor activity#GO:0140767;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cullin-RING ubiquitin ligase complex#GO:0031461;cytoplasm#GO:0005737;catalytic complex#GO:1902494;transferase complex#GO:1990234;Cul2-RING ubiquitin ligase complex#GO:0031462;ubiquitin ligase complex#GO:0000151;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=24150|UniProtKB=Q8NG06 Q8NG06 TRIM58 PTHR24103:SF393 E3 UBIQUITIN-PROTEIN LIGASE TRIM E3 UBIQUITIN-PROTEIN LIGASE TRIM58 ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 defense response to other organism#GO:0098542;response to other organism#GO:0051707;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;immune response#GO:0006955;defense response to symbiont#GO:0140546;innate immune response#GO:0045087;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;defense response#GO:0006952;response to external stimulus#GO:0009605;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;regulation of biological process#GO:0050789;immune system process#GO:0002376 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=24342|UniProtKB=O43303 O43303 CCP110 PTHR13594:SF1 CENTRIOLAR COILED-COIL PROTEIN OF 110 KDA CENTRIOLAR COILED-COIL PROTEIN OF 110 KDA cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;microtubule organizing center organization#GO:0031023;microtubule-based process#GO:0007017;centrosome duplication#GO:0051298;cellular component organization or biogenesis#GO:0071840;cell projection organization#GO:0030030;centrosome cycle#GO:0007098;cell cycle process#GO:0022402;cell cycle#GO:0007049;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;cilium organization#GO:0044782;microtubule cytoskeleton organization#GO:0000226;centriole replication#GO:0007099;organelle assembly#GO:0070925 intracellular organelle#GO:0043229;microtubule organizing center#GO:0005815;centrosome#GO:0005813;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;centriole#GO:0005814;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=25890|UniProtKB=Q86YD3 Q86YD3 TMEM25 PTHR47224:SF1 TRANSMEMBRANE PROTEIN 25 TRANSMEMBRANE PROTEIN 25 regulation of trans-synaptic signaling#GO:0099177;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;modulation of chemical synaptic transmission#GO:0050804;regulation of signal transduction#GO:0009966;regulation of multicellular organismal process#GO:0051239;regulation of cell communication#GO:0010646;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of membrane potential#GO:0042391;regulation of biological quality#GO:0065008;regulation of system process#GO:0044057;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583 HUMAN|HGNC=2600|UniProtKB=P08686 P08686 CYP21A2 PTHR24281:SF318 STEROID 21-HYDROXYLASE-RELATED STEROID 21-HYDROXYLASE binding#GO:0005488;steroid hydroxylase activity#GO:0008395;tetrapyrrole binding#GO:0046906;heme binding#GO:0020037;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;monooxygenase activity#GO:0004497;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen#GO:0016712;oxidoreductase activity#GO:0016491 cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;steroid metabolic process#GO:0008202;lipid biosynthetic process#GO:0008610;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;steroid biosynthetic process#GO:0006694 hydroxylase#PC00122 HUMAN|HGNC=16974|UniProtKB=Q6ZRS2 Q6ZRS2 SRCAP PTHR45685:SF4 HELICASE SRCAP-RELATED CHROMATIN REMODELING PROTEIN SRCAP ribonucleoside triphosphate phosphatase activity#GO:0017111;histone binding#GO:0042393;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ATP hydrolysis activity#GO:0016887;protein binding#GO:0005515;hydrolase activity#GO:0016787;ATP-dependent activity#GO:0140657;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488 cellular process#GO:0009987;cellular component organization#GO:0016043;chromatin remodeling#GO:0006338;chromatin organization#GO:0006325;cellular component organization or biogenesis#GO:0071840 chromosome#GO:0005694;organelle lumen#GO:0043233;SWI/SNF superfamily-type complex#GO:0070603;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;ATPase complex#GO:1904949;Swr1 complex#GO:0000812;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;INO80-type complex#GO:0097346;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;histone deacetylase complex#GO:0000118;chromatin#GO:0000785;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513 Wnt signaling pathway#P00057>SWI/SNF#P01435 HUMAN|HGNC=8690|UniProtKB=Q9Y5E4 Q9Y5E4 PCDHB5 PTHR24028:SF90 CADHERIN-87A PROTOCADHERIN BETA-5 cellular process#GO:0009987;cell adhesion#GO:0007155 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HUMAN|HGNC=9661|UniProtKB=P43378 P43378 PTPN9 PTHR19134:SF285 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 9 catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;protein tyrosine phosphatase activity#GO:0004725;hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HUMAN|HGNC=16196|UniProtKB=Q96PH6 Q96PH6 DEFB118 PTHR15001:SF7 BETA-DEFENSIN 123-RELATED DEFENSIN BETA 118 response to external stimulus#GO:0009605;defense response#GO:0006952;innate immune response#GO:0045087;immune system process#GO:0002376;cell killing#GO:0001906;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to other organism#GO:0051707;response to stimulus#GO:0050896;defense response to other organism#GO:0098542;defense response to symbiont#GO:0140546;immune response#GO:0006955;cellular process#GO:0009987;response to biotic stimulus#GO:0009607;response to stress#GO:0006950 antimicrobial response protein#PC00051;defense/immunity protein#PC00090 HUMAN|HGNC=10310|UniProtKB=Q07020 Q07020 RPL18 PTHR10934:SF6 60S RIBOSOMAL PROTEIN L18 LARGE RIBOSOMAL SUBUNIT PROTEIN EL18 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;translation#GO:0006412;cytoplasmic translation#GO:0002181;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;ribosome#GO:0005840;cytosol#GO:0005829;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934 ribosomal protein#PC00202;translational protein#PC00263 HUMAN|HGNC=13262|UniProtKB=Q5VWM6 Q5VWM6 PRAMEF13 PTHR14224:SF81 SIMILAR TO PREFERENTIALLY EXPRESSED ANTIGEN IN MELANOMA-LIKE 3 PRAME FAMILY MEMBER 1-RELATED molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;enzyme-substrate adaptor activity#GO:0140767;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238 ubiquitin ligase complex#GO:0000151;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;transferase complex#GO:1990234;catalytic complex#GO:1902494;Cul2-RING ubiquitin ligase complex#GO:0031462;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cullin-RING ubiquitin ligase complex#GO:0031461;cytoplasm#GO:0005737 HUMAN|HGNC=21384|UniProtKB=Q9NUH8 Q9NUH8 TMEM14B PTHR12668:SF34 TRANSMEMBRANE PROTEIN 14, 15 TRANSMEMBRANE PROTEIN 14B pigment metabolic process#GO:0042440;heme biosynthetic process#GO:0006783;cellular process#GO:0009987;tetrapyrrole biosynthetic process#GO:0033014;heme metabolic process#GO:0042168;biosynthetic process#GO:0009058;metabolic process#GO:0008152;tetrapyrrole metabolic process#GO:0033013;porphyrin-containing compound metabolic process#GO:0006778;pigment biosynthetic process#GO:0046148;porphyrin-containing compound biosynthetic process#GO:0006779 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;membrane#GO:0016020;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;intracellular organelle#GO:0043229 HUMAN|HGNC=115|UniProtKB=P53396 P53396 ACLY PTHR23118:SF42 ATP-CITRATE SYNTHASE ATP-CITRATE SYNTHASE catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746 organophosphate biosynthetic process#GO:0090407;purine-containing compound biosynthetic process#GO:0072522;acetyl-CoA metabolic process#GO:0006084;oxoacid metabolic process#GO:0043436;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;purine-containing compound metabolic process#GO:0072521;carboxylic acid biosynthetic process#GO:0046394;monocarboxylic acid metabolic process#GO:0032787;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;nucleobase-containing small molecule metabolic process#GO:0055086;acyl-CoA metabolic process#GO:0006637;nucleoside phosphate biosynthetic process#GO:1901293;monocarboxylic acid biosynthetic process#GO:0072330;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;nucleobase-containing compound biosynthetic process#GO:0034654;nucleobase-containing compound metabolic process#GO:0006139;fatty acid biosynthetic process#GO:0006633;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;sulfur compound metabolic process#GO:0006790 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 transferase#PC00220 Pyruvate metabolism#P02772>Citrate Lyase#P03137 HUMAN|HGNC=5215|UniProtKB=P56937 P56937 HSD17B7 PTHR44442:SF1 3-KETO-STEROID REDUCTASE 3-KETO-STEROID REDUCTASE_17-BETA-HYDROXYSTEROID DEHYDROGENASE 7 oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 biosynthetic process#GO:0009058;sterol biosynthetic process#GO:0016126;biological regulation#GO:0065007;steroid metabolic process#GO:0008202;lipid biosynthetic process#GO:0008610;hormone metabolic process#GO:0042445;cholesterol biosynthetic process#GO:0006695;cellular process#GO:0009987;alcohol biosynthetic process#GO:0046165;sterol metabolic process#GO:0016125;steroid biosynthetic process#GO:0006694;secondary alcohol biosynthetic process#GO:1902653;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;cholesterol metabolic process#GO:0008203;alcohol metabolic process#GO:0006066;metabolic process#GO:0008152;secondary alcohol metabolic process#GO:1902652;hormone biosynthetic process#GO:0042446;small molecule metabolic process#GO:0044281;regulation of hormone levels#GO:0010817;primary metabolic process#GO:0044238;regulation of biological quality#GO:0065008;estrogen metabolic process#GO:0008210 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226 metabolite interconversion enzyme#PC00262;reductase#PC00198 Androgen/estrogene/progesterone biosynthesis#P02727>Estradiol 17beta-dehydrogenase#P02826 HUMAN|HGNC=20081|UniProtKB=Q8WX77 Q8WX77 IGFBPL1 PTHR14186:SF16 INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-RELATED INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN-LIKE 1 molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545 regulation of cell communication#GO:0010646;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=26378|UniProtKB=Q8N7C3 Q8N7C3 TRIML2 PTHR24103:SF561 E3 UBIQUITIN-PROTEIN LIGASE TRIM E3 UBIQUITIN-PROTEIN LIGASE TRIML2-RELATED aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746 innate immune response#GO:0045087;defense response#GO:0006952;response to external stimulus#GO:0009605;immune system process#GO:0002376;defense response to other organism#GO:0098542;response to stimulus#GO:0050896;response to other organism#GO:0051707;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;immune response#GO:0006955;defense response to symbiont#GO:0140546 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=29382|UniProtKB=Q5JV73 Q5JV73 FRMPD3 PTHR46221:SF1 FERM AND PDZ DOMAIN-CONTAINING PROTEIN FAMILY MEMBER FERM AND PDZ DOMAIN-CONTAINING PROTEIN 3 HUMAN|HGNC=15355|UniProtKB=Q8NGC6 Q8NGC6 OR4K17 PTHR48002:SF34 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 4K17 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=325|UniProtKB=O15120 O15120 AGPAT2 PTHR10434:SF2 1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE 1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE BETA acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;organophosphate metabolic process#GO:0019637;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;lipid biosynthetic process#GO:0008610;phospholipid biosynthetic process#GO:0008654;glycerolipid metabolic process#GO:0046486;glycerophospholipid metabolic process#GO:0006650;lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474;metabolic process#GO:0008152;organophosphate biosynthetic process#GO:0090407 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 acyltransferase#PC00042;transferase#PC00220 HUMAN|HGNC=26891|UniProtKB=Q6P531 Q6P531 GGT6 PTHR47278:SF1 GLUTATHIONE HYDROLASE 6 GLUTATHIONE HYDROLASE 6 hydrolase#PC00121;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=17861|UniProtKB=Q8TDR0 Q8TDR0 TRAF3IP1 PTHR31363:SF0 TRAF3-INTERACTING PROTEIN 1 TRAF3-INTERACTING PROTEIN 1 cellular localization#GO:0051641;cilium organization#GO:0044782;microtubule-based transport#GO:0099111;cell projection organization#GO:0030030;regulation of cellular component organization#GO:0051128;cilium assembly#GO:0060271;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;cellular component assembly#GO:0022607;regulation of microtubule cytoskeleton organization#GO:0070507;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;establishment of localization in cell#GO:0051649;cell projection assembly#GO:0030031;cellular process#GO:0009987;localization#GO:0051179;organelle assembly#GO:0070925;regulation of microtubule-based process#GO:0032886;regulation of cytoskeleton organization#GO:0051493;microtubule-based movement#GO:0007018;regulation of cellular process#GO:0050794;intraciliary transport#GO:0042073;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;plasma membrane bounded cell projection assembly#GO:0120031;intracellular transport#GO:0046907;transport#GO:0006810;cytoskeleton-dependent intracellular transport#GO:0030705;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036 intraciliary transport particle#GO:0030990;intracellular organelle#GO:0043229;cilium#GO:0005929;axoneme#GO:0005930;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;intraciliary transport particle B#GO:0030992;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;protein-containing complex#GO:0032991;ciliary plasm#GO:0097014;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232 HUMAN|HGNC=17500|UniProtKB=Q9H8Y8 Q9H8Y8 GORASP2 PTHR12893:SF1 GOLGI REASSEMBLY STACKING PROTEIN GRASP GOLGI REASSEMBLY-STACKING PROTEIN 2 cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;Golgi organization#GO:0007030;cellular component organization or biogenesis#GO:0071840;endomembrane system organization#GO:0010256 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794 HUMAN|HGNC=30129|UniProtKB=Q99575 Q99575 POP1 PTHR22731:SF3 RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP1 RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP1 catalytic activity, acting on a tRNA#GO:0140101;nuclease activity#GO:0004518;hydrolase activity#GO:0016787;ribonuclease P activity#GO:0004526;catalytic activity, acting on RNA#GO:0140098;RNA endonuclease activity#GO:0004521;RNA nuclease activity#GO:0004540;endonuclease activity#GO:0004519;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640 cellular component biogenesis#GO:0044085;endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000479;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;maturation of SSU-rRNA#GO:0030490;RNA processing#GO:0006396;biosynthetic process#GO:0009058;metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;ribosomal small subunit biogenesis#GO:0042274;endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000447;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;maturation of 5.8S rRNA#GO:0000460;RNA biosynthetic process#GO:0032774;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364 cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;multimeric ribonuclease P complex#GO:0030681;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nucleolar ribonuclease P complex#GO:0005655;organelle lumen#GO:0043233;sno(s)RNA-containing ribonucleoprotein complex#GO:0005732;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoribonuclease complex#GO:1902555;ribonuclease P complex#GO:0030677;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;ribonuclease MRP complex#GO:0000172;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;endonuclease complex#GO:1905348 endoribonuclease#PC00094;RNA metabolism protein#PC00031 HUMAN|HGNC=391|UniProtKB=P31749 P31749 AKT1 PTHR24356:SF171 SERINE/THREONINE-PROTEIN KINASE RAC-ALPHA SERINE_THREONINE-PROTEIN KINASE transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 regulation of apoptotic process#GO:0042981;cell surface receptor signaling pathway#GO:0007166;cellular response to oxygen-containing compound#GO:1901701;positive regulation of biological process#GO:0048518;negative regulation of programmed cell death#GO:0043069;signal transduction#GO:0007165;cellular process#GO:0009987;response to hormone#GO:0009725;response to chemical#GO:0042221;insulin receptor signaling pathway#GO:0008286;response to oxygen-containing compound#GO:1901700;cellular response to chemical stimulus#GO:0070887;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;positive regulation of cell motility#GO:2000147;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;signaling#GO:0023052;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;cellular response to hormone stimulus#GO:0032870;regulation of cell migration#GO:0030334;cellular response to insulin stimulus#GO:0032869;negative regulation of cellular process#GO:0048523;positive regulation of locomotion#GO:0040017;positive regulation of cellular process#GO:0048522;positive regulation of cell migration#GO:0030335;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;response to peptide hormone#GO:0043434;negative regulation of apoptotic process#GO:0043066;cellular response to nitrogen compound#GO:1901699;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;response to nitrogen compound#GO:1901698;intracellular signal transduction#GO:0035556;regulation of cell motility#GO:2000145;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;response to insulin#GO:0032868;cellular response to stimulus#GO:0051716;cellular response to peptide hormone stimulus#GO:0071375;regulation of cellular process#GO:0050794 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167 Gonadotropin-releasing hormone receptor pathway#P06664>AKT#P06779;Hypoxia response via HIF activation#P00030>AKT#P00819;VEGF signaling pathway#P00056>Akt/PKB#P01408;Angiogenesis#P00005>Akt#P00223;Endothelin signaling pathway#P00019>Akt#P00589;FGF signaling pathway#P00021>Akt#P00632;Huntington disease#P00029>Akt#P00805;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>AKT#P00827;EGF receptor signaling pathway#P00018>Akt#P00551;PI3 kinase pathway#P00048>PKB#P01179;FAS signaling pathway#P00020>ASK1#P00614;p53 pathway feedback loops 2#P04398>AKT#P04665;p53 pathway by glucose deprivation#P04397>Akt#P04641;T cell activation#P00053>Akt#P01332;p53 pathway#P00059>Akt#P01486;CCKR signaling map#P06959>AKT1#P07152;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>AKT#P00894;Apoptosis signaling pathway#P00006>AKT#P00260;Interleukin signaling pathway#P00036>PKB#P00973;Ras Pathway#P04393>AKT#P04570 HUMAN|HGNC=22210|UniProtKB=Q9ULK2 Q9ULK2 ATXN7L1 PTHR15117:SF9 ATAXIN 7 RELATED ATAXIN-7-LIKE PROTEIN 1 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 HUMAN|HGNC=484|UniProtKB=Q15389 Q15389 ANGPT1 PTHR19143:SF156 FIBRINOGEN/TENASCIN/ANGIOPOEITIN ANGIOPOIETIN-1 enzyme binding#GO:0019899;protein kinase binding#GO:0019901;signaling receptor binding#GO:0005102;kinase binding#GO:0019900;binding#GO:0005488;protein tyrosine kinase binding#GO:1990782;protein binding#GO:0005515;receptor tyrosine kinase binding#GO:0030971 anatomical structure formation involved in morphogenesis#GO:0048646;vasculature development#GO:0001944;multicellular organism development#GO:0007275;cell surface receptor signaling pathway#GO:0007166;developmental process#GO:0032502;tube development#GO:0035295;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;cellular process#GO:0009987;signal transduction#GO:0007165;system development#GO:0048731;angiogenesis#GO:0001525;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;animal gross anatomical part developmental process#GO:0160108;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;circulatory system development#GO:0072359;tube morphogenesis#GO:0035239;blood vessel development#GO:0001568;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;blood vessel morphogenesis#GO:0048514 cellular anatomical structure#GO:0110165;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576 intercellular signal molecule#PC00207 Angiogenesis#P00005>Ang-1#P00248 HUMAN|HGNC=5420|UniProtKB=P01570 P01570 IFNA14 PTHR11691:SF67 TYPE I INTERFERON INTERFERON ALPHA-14 signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;molecular function activator activity#GO:0140677;protein-containing complex binding#GO:0044877;protein binding#GO:0005515;cytokine activity#GO:0005125;cytokine receptor binding#GO:0005126;signaling receptor binding#GO:0005102;binding#GO:0005488 defense response#GO:0006952;response to external stimulus#GO:0009605;innate immune response#GO:0045087;immune response#GO:0006955;response to other organism#GO:0051707;adaptive immune response#GO:0002250;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;cell activation#GO:0001775;cytokine-mediated signaling pathway#GO:0019221;response to nitrogen compound#GO:1901698;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;leukocyte activation#GO:0045321;response to external biotic stimulus#GO:0043207;regulation of cellular process#GO:0050794;leukocyte activation involved in immune response#GO:0002366;cell surface receptor signaling pathway#GO:0007166;natural killer cell activation#GO:0030101;immune effector process#GO:0002252;humoral immune response#GO:0006959;B cell activation#GO:0042113;cellular process#GO:0009987;signal transduction#GO:0007165;defense response to symbiont#GO:0140546;lymphocyte activation involved in immune response#GO:0002285;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;T cell activation involved in immune response#GO:0002286;defense response to other organism#GO:0098542;lymphocyte activation#GO:0046649;response to cytokine#GO:0034097;response to chemical#GO:0042221;B cell activation involved in immune response#GO:0002312;type I interferon-mediated signaling pathway#GO:0060337;immune system process#GO:0002376;response to peptide#GO:1901652;cell activation involved in immune response#GO:0002263;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;T cell activation#GO:0042110;biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052;response to stimulus#GO:0050896 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 cytokine#PC00083;interferon superfamily#PC00127 HUMAN|HGNC=24544|UniProtKB=Q9H6Y7 Q9H6Y7 RNF167 PTHR22765:SF35 RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING E3 UBIQUITIN-PROTEIN LIGASE RNF167 catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630 protein metabolic process#GO:0019538;localization#GO:0051179;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;organelle localization#GO:0051640;regulation of cell cycle#GO:0051726;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;modification-dependent protein catabolic process#GO:0019941;regulation of biological process#GO:0050789;primary metabolic process#GO:0044238;negative regulation of biological process#GO:0048519;ubiquitin-dependent protein catabolic process#GO:0006511;negative regulation of cell cycle#GO:0045786;macromolecule metabolic process#GO:0043170;macromolecule catabolic process#GO:0009057;negative regulation of cellular process#GO:0048523;metabolic process#GO:0008152;biological regulation#GO:0065007;cellular process#GO:0009987;lysosome localization#GO:0032418 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=16626|UniProtKB=Q8WZA2 Q8WZA2 RAPGEF4 PTHR23113:SF175 GUANINE NUCLEOTIDE EXCHANGE FACTOR RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 4 guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;intracellular signaling cassette#GO:0141124;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;Ras protein signal transduction#GO:0007265;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 guanyl-nucleotide exchange factor#PC00113 HUMAN|Gene=ACOT7L|UniProtKB=Q6ZUV0 Q6ZUV0 ACOT7L PTHR11049:SF29 ACYL COENZYME A THIOESTER HYDROLASE CYTOSOLIC ACYL COENZYME A THIOESTER HYDROLASE-LIKE hydrolase activity#GO:0016787;thiolester hydrolase activity#GO:0016790;hydrolase activity, acting on ester bonds#GO:0016788;acyl-CoA hydrolase activity#GO:0016289;deacylase activity#GO:0160215;fatty acyl-CoA hydrolase activity#GO:0047617;catalytic activity#GO:0003824 monocarboxylic acid catabolic process#GO:0072329;nucleobase-containing compound metabolic process#GO:0006139;sulfur compound metabolic process#GO:0006790;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;lipid catabolic process#GO:0016042;carboxylic acid catabolic process#GO:0046395;acyl-CoA metabolic process#GO:0006637;nucleobase-containing small molecule metabolic process#GO:0055086;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;small molecule catabolic process#GO:0044282;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;purine-containing compound metabolic process#GO:0072521;fatty acid catabolic process#GO:0009062;oxoacid metabolic process#GO:0043436 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 esterase#PC00097 HUMAN|HGNC=25416|UniProtKB=Q14CW9 Q14CW9 ATXN7L3 PTHR46367:SF1 ATAXIN-7-LIKE PROTEIN 3 ATAXIN-7-LIKE PROTEIN 3 transcription coactivator activity#GO:0003713;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;histone acetyltransferase complex#GO:0000123;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;chromatin#GO:0000785;nucleus#GO:0005634;DUBm complex#GO:0071819;SAGA complex#GO:0000124;peptidase complex#GO:1905368;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;protein acetyltransferase complex#GO:0031248;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;acetyltransferase complex#GO:1902493;membrane-bounded organelle#GO:0043227;SAGA-type complex#GO:0070461;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=30295|UniProtKB=Q96S79 Q96S79 RASL10B PTHR46350:SF1 RAS LIKE FAMILY 10 MEMBER B-RELATED RAS-LIKE PROTEIN FAMILY MEMBER 10B HUMAN|HGNC=16245|UniProtKB=Q9BYG5 Q9BYG5 PARD6B PTHR14102:SF4 PAR-6-RELATED PARTITIONING DEFECTIVE 6 HOMOLOG BETA protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 cytoskeleton organization#GO:0007010;cell junction organization#GO:0034330;centrosome cycle#GO:0007098;cellular process#GO:0009987;cell cycle process#GO:0022402;organelle organization#GO:0006996;cell cycle#GO:0007049;cellular component organization#GO:0016043;microtubule organizing center organization#GO:0031023;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226;cell-cell junction maintenance#GO:0045217;cell-cell junction organization#GO:0045216;establishment or maintenance of cell polarity#GO:0007163 catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554;cell cortex#GO:0005938;apical plasma membrane#GO:0016324;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;transferase complex#GO:1990234;apical part of cell#GO:0045177;protein kinase complex#GO:1902911;cell periphery#GO:0071944;nucleus#GO:0005634;membrane#GO:0016020;cytoplasm#GO:0005737;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;plasma membrane region#GO:0098590 tight junction#PC00214;cell junction protein#PC00070 HUMAN|HGNC=8736|UniProtKB=A6NKB5 A6NKB5 PCNX2 PTHR12372:SF5 PECANEX PECANEX-LIKE PROTEIN 2 HUMAN|HGNC=26179|UniProtKB=Q499Z4 Q499Z4 ZNF672 PTHR24408:SF71 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 672 transcription regulator activity#GO:0140110;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=25194|UniProtKB=Q96B21 Q96B21 TMEM45B PTHR16007:SF59 EPIDIDYMAL MEMBRANE PROTEIN E9-RELATED TRANSMEMBRANE PROTEIN 45B HUMAN|HGNC=11992|UniProtKB=Q13472 Q13472 TOP3A PTHR11390:SF21 PROKARYOTIC DNA TOPOISOMERASE DNA TOPOISOMERASE 3-ALPHA catalytic activity, acting on DNA#GO:0140097;isomerase activity#GO:0016853;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543 DNA damage response#GO:0006974;DNA recombination#GO:0006310;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;chromosome organization#GO:0051276;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;response to stress#GO:0006950;organelle organization#GO:0006996;nucleobase-containing compound metabolic process#GO:0006139;cellular response to stress#GO:0033554;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;response to stimulus#GO:0050896 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;chromosome#GO:0005694;DNA helicase complex#GO:0033202;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232 DNA metabolism protein#PC00009 HUMAN|HGNC=20338|UniProtKB=Q7L622 Q7L622 G2E3 PTHR12420:SF37 PHD FINGER PROTEIN G2_M PHASE-SPECIFIC E3 UBIQUITIN-PROTEIN LIGASE acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;negative regulation of apoptotic signaling pathway#GO:2001234;regulation of signaling#GO:0023051;regulation of apoptotic signaling pathway#GO:2001233;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of intrinsic apoptotic signaling pathway#GO:2001242;negative regulation of cellular process#GO:0048523;regulation of apoptotic process#GO:0042981;negative regulation of intrinsic apoptotic signaling pathway#GO:2001243;regulation of response to stimulus#GO:0048583;negative regulation of apoptotic process#GO:0043066;negative regulation of response to stimulus#GO:0048585;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of signal transduction#GO:0009968;negative regulation of programmed cell death#GO:0043069 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA metabolism protein#PC00009 HUMAN|HGNC=2888|UniProtKB=Q9NRI5 Q9NRI5 DISC1 PTHR14332:SF3 DISRUPTED IN SCHIZOPHRENIA 1 PROTEIN DISRUPTED IN SCHIZOPHRENIA 1 PROTEIN cell motility#GO:0048870;central nervous system development#GO:0007417;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cilium organization#GO:0044782;system development#GO:0048731;anatomical structure development#GO:0048856;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;organelle assembly#GO:0070925;plasma membrane bounded cell projection organization#GO:0120036;nervous system development#GO:0007399;head development#GO:0060322;cell migration#GO:0016477;multicellular organismal process#GO:0032501;brain development#GO:0007420;cellular component assembly#GO:0022607;cellular process#GO:0009987;cell projection assembly#GO:0030031;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;animal organ development#GO:0048513;cellular component organization or biogenesis#GO:0071840;neuron migration#GO:0001764;multicellular organism development#GO:0007275;developmental process#GO:0032502;plasma membrane bounded cell projection assembly#GO:0120031 postsynapse#GO:0098794;asymmetric synapse#GO:0032279;organelle#GO:0043226;cellular anatomical structure#GO:0110165;synapse#GO:0045202;intracellular organelle#GO:0043229;postsynaptic density#GO:0014069;intracellular anatomical structure#GO:0005622;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;postsynaptic specialization#GO:0099572;neuron to neuron synapse#GO:0098984;microtubule organizing center#GO:0005815;centrosome#GO:0005813;cytoskeleton#GO:0005856;cell junction#GO:0030054;membraneless organelle#GO:0043228 HUMAN|HGNC=37244|UniProtKB=O75264 O75264 SMIM24 PTHR15296:SF2 MEMBRANE-ASSOCIATED PROTEIN MAP17 SMALL INTEGRAL MEMBRANE PROTEIN 24 HUMAN|HGNC=16486|UniProtKB=O75689 O75689 ADAP1 PTHR46021:SF5 ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 1-LIKE PROTEIN ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 1 phosphatidylinositol phosphate binding#GO:1901981;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;molecular function regulator activity#GO:0098772;phospholipid binding#GO:0005543;enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234;lipid binding#GO:0008289;molecular function activator activity#GO:0140677;anion binding#GO:0043168;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167 plasma membrane#GO:0005886;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=1973|UniProtKB=Q9GZS9 Q9GZS9 CHST5 PTHR10704:SF13 CARBOHYDRATE SULFOTRANSFERASE CARBOHYDRATE SULFOTRANSFERASE 5 catalytic activity#GO:0003824;transferase activity#GO:0016740;sulfotransferase activity#GO:0008146;transferase activity, transferring sulphur-containing groups#GO:0016782 amino sugar metabolic process#GO:0006040;biosynthetic process#GO:0009058;proteoglycan biosynthetic process#GO:0030166;primary metabolic process#GO:0044238;sulfur compound metabolic process#GO:0006790;glycoprotein biosynthetic process#GO:0009101;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;proteoglycan metabolic process#GO:0006029;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;Golgi apparatus subcompartment#GO:0098791;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802 metabolite interconversion enzyme#PC00262;transferase#PC00220 HUMAN|HGNC=11779|UniProtKB=Q08188 Q08188 TGM3 PTHR11590:SF36 PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE E catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746 cellular process#GO:0009987;epithelium development#GO:0060429;cell differentiation#GO:0030154;tissue development#GO:0009888;epidermal cell differentiation#GO:0009913;epithelial cell differentiation#GO:0030855;skin development#GO:0043588;keratinocyte differentiation#GO:0030216;animal gross anatomical part developmental process#GO:0160108;epidermis development#GO:0008544;developmental process#GO:0032502;animal organ development#GO:0048513;cellular developmental process#GO:0048869;anatomical structure development#GO:0048856 transferase#PC00220 HUMAN|HGNC=2294|UniProtKB=P10176 P10176 COX8A PTHR16717:SF1 CYTOCHROME C OXIDASE POLYPEPTIDE VIII CYTOCHROME C OXIDASE SUBUNIT 8A, MITOCHONDRIAL catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;respiratory chain complex IV#GO:0045277;transmembrane transporter complex#GO:1902495;mitochondrion#GO:0005739;cytochrome complex#GO:0070069;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;transporter complex#GO:1990351;respiratory chain complex#GO:0098803;oxidoreductase complex#GO:1990204;membrane#GO:0016020;cytoplasm#GO:0005737;protein-containing complex#GO:0032991 metabolite interconversion enzyme#PC00262;oxidase#PC00175;oxidoreductase#PC00176 HUMAN|HGNC=387|UniProtKB=P17516 P17516 AKR1C4 PTHR11732:SF556 ALDO/KETO REDUCTASE ALDO-KETO REDUCTASE FAMILY 1 MEMBER C4 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen#GO:0016709;monooxygenase activity#GO:0004497;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;oxidoreductase activity#GO:0016491;alcohol dehydrogenase (NADP+) activity#GO:0008106;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614 steroid metabolic process#GO:0008202;lipid metabolic process#GO:0006629;cellular process#GO:0009987;primary metabolic process#GO:0044238;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 oxidoreductase#PC00176;reductase#PC00198 HUMAN|HGNC=18243|UniProtKB=Q8NDN9 Q8NDN9 RCBTB1 PTHR22870:SF224 REGULATOR OF CHROMOSOME CONDENSATION RCC1 AND BTB DOMAIN-CONTAINING PROTEIN 1 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=4217|UniProtKB=Q9UK05 Q9UK05 GDF2 PTHR11848:SF157 TGF-BETA FAMILY GROWTH_DIFFERENTIATION FACTOR 2 cytokine activity#GO:0005125;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772 enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;cellular response to growth factor stimulus#GO:0071363;regulation of cellular process#GO:0050794;response to growth factor#GO:0070848;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;positive regulation of epithelial cell proliferation#GO:0050679;signaling#GO:0023052;response to endogenous stimulus#GO:0009719;positive regulation of cell population proliferation#GO:0008284;BMP signaling pathway#GO:0030509;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;cell surface receptor signaling pathway#GO:0007166;cellular response to BMP stimulus#GO:0071773;response to BMP#GO:0071772;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;biological regulation#GO:0065007;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 growth factor#PC00112 TGF-beta signaling pathway#P00052>TGFbeta#P01286 HUMAN|HGNC=17934|UniProtKB=Q9NZ20 Q9NZ20 PLA2G3 PTHR12253:SF19 RH14732P GROUP 3 SECRETORY PHOSPHOLIPASE A2 HUMAN|HGNC=20861|UniProtKB=Q9ULF5 Q9ULF5 SLC39A10 PTHR12191:SF14 SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER ZIP10 monoatomic cation transmembrane transporter activity#GO:0008324;symporter activity#GO:0015293;transition metal ion transmembrane transporter activity#GO:0046915;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873;solute:monoatomic cation symporter activity#GO:0015294;monoatomic ion transmembrane transporter activity#GO:0015075;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;zinc ion transmembrane transporter activity#GO:0005385;bicarbonate transmembrane transporter activity#GO:0015106 intracellular monoatomic ion homeostasis#GO:0006873;inorganic ion import across plasma membrane#GO:0099587;homeostatic process#GO:0042592;metal ion transport#GO:0030001;import across plasma membrane#GO:0098739;transition metal ion transport#GO:0000041;zinc ion transmembrane transport#GO:0071577;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801;monoatomic ion transmembrane transport#GO:0034220;zinc ion transport#GO:0006829;monoatomic cation transmembrane transport#GO:0098655;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;transport#GO:0006810;intracellular monoatomic cation homeostasis#GO:0030003;cellular homeostasis#GO:0019725;inorganic cation import across plasma membrane#GO:0098659;intracellular chemical homeostasis#GO:0055082;import into cell#GO:0098657;establishment of localization#GO:0051234 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227;secondary carrier transporter#PC00258 HUMAN|HGNC=29325|UniProtKB=Q6P9B6 Q6P9B6 MEAK7 PTHR23354:SF131 NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED MTOR-ASSOCIATED PROTEIN MEAK7 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;response to stress#GO:0006950;TOR signaling#GO:0031929;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;response to oxidative stress#GO:0006979 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=2230|UniProtKB=P53621 P53621 COPA PTHR19876:SF1 COATOMER COATOMER SUBUNIT ALPHA establishment of localization#GO:0051234;vesicle-mediated transport#GO:0016192;localization#GO:0051179;transport#GO:0006810;Golgi vesicle transport#GO:0048193;cellular process#GO:0009987;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890 vesicle membrane#GO:0012506;membrane#GO:0016020;vesicle coat#GO:0030120;cytoplasm#GO:0005737;COPI-coated vesicle#GO:0030137;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;Golgi-associated vesicle#GO:0005798;Golgi apparatus#GO:0005794;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;Golgi-associated vesicle membrane#GO:0030660;coated vesicle membrane#GO:0030662;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;COPI vesicle coat#GO:0030126;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;coated vesicle#GO:0030135;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;coated membrane#GO:0048475;membrane coat#GO:0030117 vesicle coat protein#PC00235 HUMAN|HGNC=14889|UniProtKB=Q9UBS4 Q9UBS4 DNAJB11 PTHR44298:SF1 DNAJ HOMOLOG SUBFAMILY B MEMBER 11 DNAJ HOMOLOG SUBFAMILY B MEMBER 11 protein binding#GO:0005515;binding#GO:0005488 metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226 chaperone#PC00072 HUMAN|HGNC=5890|UniProtKB=P01705 P01705 IGLV2-23 PTHR23267:SF407 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN LAMBDA VARIABLE 2-14-RELATED immune response#GO:0006955;immune system process#GO:0002376;response to stimulus#GO:0050896 protein-containing complex#GO:0032991 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=4401|UniProtKB=O14775 O14775 GNB5 PTHR19850:SF36 GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-5 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;signaling receptor complex adaptor activity#GO:0030159;signaling adaptor activity#GO:0035591 signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;response to nitrogen compound#GO:1901698;cell communication#GO:0007154;response to oxygen-containing compound#GO:1901700;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;biological regulation#GO:0065007;cellular response to nitrogen compound#GO:1901699;response to chemical#GO:0042221;cellular process#GO:0009987;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;G protein-coupled dopamine receptor signaling pathway#GO:0007212 cellular anatomical structure#GO:0110165;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;cytoplasmic side of plasma membrane#GO:0009898;intracellular anatomical structure#GO:0005622;side of membrane#GO:0098552;catalytic complex#GO:1902494;extrinsic component of cytoplasmic side of plasma membrane#GO:0031234;plasma membrane#GO:0005886;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020;extrinsic component of membrane#GO:0019898;extrinsic component of plasma membrane#GO:0019897;cytoplasmic side of membrane#GO:0098562 heterotrimeric G-protein#PC00117;G-protein#PC00020;protein-binding activity modulator#PC00095 Beta3 adrenergic receptor signaling pathway#P04379>G-Protein#P04448;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Gbeta5L#P00748;Beta1 adrenergic receptor signaling pathway#P04377>G-Protein#P04436;Opioid prodynorphin pathway#P05916>G-protein#P06002;Metabotropic glutamate receptor group II pathway#P00040>G-protein#P01047;Histamine H2 receptor mediated signaling pathway#P04386>G-Protein#P04490;Beta2 adrenergic receptor signaling pathway#P04378>G-Protein#P04443;Histamine H1 receptor mediated signaling pathway#P04385>G-Protein#P04488;Opioid proenkephalin pathway#P05915>G-protein#P05994;5HT1 type receptor mediated signaling pathway#P04373>G-protein#P04408;PI3 kinase pathway#P00048>Gbetagamma#P01188;Thyrotropin-releasing hormone receptor signaling pathway#P04394>G-Protein#P04584;5HT2 type receptor mediated signaling pathway#P04374>G-protein#P04416;Enkephalin release#P05913>G-Protein (i)#P05974;Enkephalin release#P05913>G-Protein (s)#P05977;Gonadotropin-releasing hormone receptor pathway#P06664>Gbeta#P06769;5HT4 type receptor mediated signaling pathway#P04376>G-protein#P04430;Metabotropic glutamate receptor group III pathway#P00039>G-Protein#P01045;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>G-Protein#P01073;Opioid proopiomelanocortin pathway#P05917>G-protein#P06012;Angiotensin II-stimulated signaling through G proteins and beta-arrestin#P05911>Gbeta#P05930;Oxytocin receptor mediated signaling pathway#P04391>G-Protein#P04534;Cortocotropin releasing factor receptor signaling pathway#P04380>G-Protein#P04458;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>G-Protein#P01085 HUMAN|HGNC=18262|UniProtKB=Q8IWA4 Q8IWA4 MFN1 PTHR10465:SF2 TRANSMEMBRANE GTPASE FZO1 MITOFUSIN-1 ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818 mitochondrion organization#GO:0007005;organelle fusion#GO:0048284;cellular process#GO:0009987;mitochondrial fusion#GO:0008053;organelle organization#GO:0006996;cellular component organization#GO:0016043;mitochondrion localization#GO:0051646;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;organelle localization#GO:0051640 bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;mitochondrial outer membrane#GO:0005741;cytoplasm#GO:0005737;organelle outer membrane#GO:0031968;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;outer membrane#GO:0019867;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;organelle envelope#GO:0031967 HUMAN|HGNC=11052|UniProtKB=P31641 P31641 SLC6A6 PTHR11616:SF141 SODIUM/CHLORIDE DEPENDENT TRANSPORTER SODIUM- AND CHLORIDE-DEPENDENT TAURINE TRANSPORTER amino acid:sodium symporter activity#GO:0005283;solute:sodium symporter activity#GO:0015370;carboxylic acid transmembrane transporter activity#GO:0046943;sodium ion transmembrane transporter activity#GO:0015081;active transmembrane transporter activity#GO:0022804;solute:monoatomic cation symporter activity#GO:0015294;transmembrane transporter activity#GO:0022857;chloride transmembrane transporter activity#GO:0015108;monoatomic cation transmembrane transporter activity#GO:0008324;symporter activity#GO:0015293;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;monoatomic anion transmembrane transporter activity#GO:0008509;amino acid transmembrane transporter activity#GO:0015171 transport#GO:0006810;organic acid transport#GO:0015849;amino acid transport#GO:0006865;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;nitrogen compound transport#GO:0071705;cellular process#GO:0009987;sodium ion transport#GO:0006814;sodium ion transmembrane transport#GO:0035725;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane#GO:0005886 primary active transporter#PC00068 HUMAN|HGNC=9035|UniProtKB=P47712 P47712 PLA2G4A PTHR10728:SF13 CYTOSOLIC PHOSPHOLIPASE A2 CYTOSOLIC PHOSPHOLIPASE A2 metal ion binding#GO:0046872;lipid binding#GO:0008289;binding#GO:0005488;calcium ion binding#GO:0005509;A2-type glycerophospholipase activity#GO:0004623;glycerophospholipase activity#GO:0004620;phospholipase activity#GO:0120569;hydrolase activity#GO:0016787;cation binding#GO:0043169;lipase activity#GO:0016298;small molecule binding#GO:0036094;ion binding#GO:0043167;carboxylic ester hydrolase activity#GO:0052689;catalytic activity#GO:0003824;phospholipid binding#GO:0005543;hydrolase activity, acting on ester bonds#GO:0016788 phospholipid metabolic process#GO:0006644;glycerolipid metabolic process#GO:0046486;glycerophospholipid metabolic process#GO:0006650;phospholipid catabolic process#GO:0009395;catabolic process#GO:0009056;lipid catabolic process#GO:0016042;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;glycerophospholipid catabolic process#GO:0046475;organophosphate catabolic process#GO:0046434;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;glycerolipid catabolic process#GO:0046503 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 phospholipase#PC00186 Oxidative stress response#P00046>cPLA2#P01134;Endothelin signaling pathway#P00019>cPLA2#P00583;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PLA2#P00855;VEGF signaling pathway#P00056>cPLA2#P01409;Angiogenesis#P00005>PLA2#P00227;Gonadotropin-releasing hormone receptor pathway#P06664>PLA2#P06738;CCKR signaling map#P06959>PLA2#P07086;Angiogenesis#P00005>cPLA2#P00251 HUMAN|HGNC=28648|UniProtKB=Q8IYB7 Q8IYB7 DIS3L2 PTHR23355:SF68 RIBONUCLEASE DIS3-LIKE EXONUCLEASE 2 hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on RNA#GO:0140098;3'-5' exonuclease activity#GO:0008408;RNA nuclease activity#GO:0004540;3'-5'-RNA exonuclease activity#GO:0000175;exonuclease activity#GO:0004527;nuclease activity#GO:0004518;hydrolase activity#GO:0016787 negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;nucleic acid catabolic process#GO:0141188;mRNA catabolic process#GO:0006402;nucleobase-containing compound catabolic process#GO:0034655;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;negative regulation of gene expression#GO:0010629;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;RNA catabolic process#GO:0006401;RNA metabolic process#GO:0016070 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 exoribonuclease#PC00099 HUMAN|HGNC=30668|UniProtKB=O60687 O60687 SRPX2 PTHR46343:SF3 HYR DOMAIN-CONTAINING PROTEIN SUSHI REPEAT-CONTAINING PROTEIN SRPX2 signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515 regulation of cell migration#GO:0030334;positive regulation of developmental process#GO:0051094;positive regulation of locomotion#GO:0040017;positive regulation of synapse assembly#GO:0051965;cell-cell adhesion#GO:0098609;positive regulation of cell migration#GO:0030335;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of cellular component biogenesis#GO:0044089;regulation of synapse assembly#GO:0051963;regulation of multicellular organismal process#GO:0051239;regulation of locomotion#GO:0040012;biological regulation#GO:0065007;regulation of synapse organization#GO:0050807;regulation of cell junction assembly#GO:1901888;positive regulation of cellular component organization#GO:0051130;cell adhesion#GO:0007155;regulation of synapse structure or activity#GO:0050803;regulation of nervous system development#GO:0051960;regulation of cell motility#GO:2000145;regulation of biological quality#GO:0065008;positive regulation of cell motility#GO:2000147;positive regulation of multicellular organismal process#GO:0051240;regulation of multicellular organismal development#GO:2000026;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;positive regulation of nervous system development#GO:0051962;regulation of cellular component organization#GO:0051128;regulation of cellular component biogenesis#GO:0044087;regulation of developmental process#GO:0050793 HUMAN|HGNC=17059|UniProtKB=Q9NTJ5 Q9NTJ5 SACM1L PTHR45662:SF2 PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1 PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1 phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791 phospholipid dephosphorylation#GO:0046839;phosphate-containing compound metabolic process#GO:0006796;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;phospholipid metabolic process#GO:0006644;glycerolipid metabolic process#GO:0046486;glycerophospholipid metabolic process#GO:0006650;lipid metabolic process#GO:0006629;phosphatidylinositol metabolic process#GO:0046488;metabolic process#GO:0008152;phosphatidylinositol dephosphorylation#GO:0046856;lipid modification#GO:0030258;dephosphorylation#GO:0016311 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 phosphatase#PC00181;hydrolase#PC00121 HUMAN|HGNC=27752|UniProtKB=Q86T96 Q86T96 RNF180 PTHR46717:SF1 E3 UBIQUITIN-PROTEIN LIGASE RNF180 E3 UBIQUITIN-PROTEIN LIGASE RNF180 transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin protein ligase activity#GO:0061630;enzyme binding#GO:0019899;ubiquitin-like protein transferase activity#GO:0019787;binding#GO:0005488;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;protein binding#GO:0005515 biological regulation#GO:0065007;positive regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032436;biogenic amine metabolic process#GO:0006576;positive regulation of macromolecule metabolic process#GO:0010604;regulation of proteasomal protein catabolic process#GO:0061136;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;amine metabolic process#GO:0009308;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;regulation of primary metabolic process#GO:0080090;regulation of catabolic process#GO:0009894;positive regulation of catabolic process#GO:0009896;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;metabolic process#GO:0008152;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;indole-containing compound metabolic process#GO:0042430;positive regulation of ubiquitin-dependent protein catabolic process#GO:2000060;phenol-containing compound metabolic process#GO:0018958;regulation of biological process#GO:0050789;positive regulation of proteasomal protein catabolic process#GO:1901800;serotonin metabolic process#GO:0042428;regulation of protein catabolic process#GO:0042176;positive regulation of protein catabolic process#GO:0045732;catecholamine metabolic process#GO:0006584;positive regulation of metabolic process#GO:0009893;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434;positive regulation of protein metabolic process#GO:0051247 endoplasmic reticulum membrane#GO:0005789;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane#GO:0016020;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=25663|UniProtKB=Q9HAJ7 Q9HAJ7 SAP30L PTHR13286:SF5 SAP30 HISTONE DEACETYLASE COMPLEX SUBUNIT SAP30L transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 membrane-enclosed lumen#GO:0031974;histone deacetylase complex#GO:0000118;nucleus#GO:0005634;protein-containing complex#GO:0032991;nuclear protein-containing complex#GO:0140513;organelle lumen#GO:0043233;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=12220|UniProtKB=A0A0A0MS03 A0A0A0MS03 TRBV5-3 PTHR23268:SF6 T-CELL RECEPTOR BETA CHAIN T CELL RECEPTOR BETA VARIABLE 5-5-RELATED cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=32033|UniProtKB=Q4V348 Q4V348 ZNF658B PTHR24376:SF249 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 594-RELATED negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255 gene-specific transcriptional regulator#PC00264;zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=26501|UniProtKB=B6SEH8 B6SEH8 ERVV-1 PTHR10424:SF84 VIRAL ENVELOPE PROTEIN ENDOGENOUS RETROVIRUS GROUP V MEMBER 1 ENV POLYPROTEIN developmental process#GO:0032502;cell-cell fusion#GO:0140253;animal gross anatomical part developmental process#GO:0160108;striated muscle cell differentiation#GO:0051146;syncytium formation by cell-cell fusion#GO:0000768;anatomical structure development#GO:0048856;cellular developmental process#GO:0048869;muscle cell differentiation#GO:0042692;cellular process#GO:0009987;myoblast fusion#GO:0007520;cell differentiation#GO:0030154;muscle structure development#GO:0061061 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 viral or transposable element protein#PC00237 HUMAN|HGNC=20798|UniProtKB=P78383 P78383 SLC35B1 PTHR10778:SF10 SOLUTE CARRIER FAMILY 35 MEMBER B SOLUTE CARRIER FAMILY 35 MEMBER B1 UDP-galactose transmembrane transporter activity#GO:0005459;organophosphate ester transmembrane transporter activity#GO:0015605;nucleobase-containing compound transmembrane transporter activity#GO:0015932;nucleotide-sugar transmembrane transporter activity#GO:0005338;carbohydrate derivative transmembrane transporter activity#GO:1901505;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 nucleobase-containing compound transport#GO:0015931;organophosphate ester transport#GO:0015748;nucleotide-sugar transmembrane transport#GO:0015780;cellular process#GO:0009987;carbohydrate derivative transport#GO:1901264;nitrogen compound transport#GO:0071705;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;transport#GO:0006810 endoplasmic reticulum membrane#GO:0005789;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;endoplasmic reticulum#GO:0005783;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane#GO:0016020;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 secondary carrier transporter#PC00258 HUMAN|HGNC=30990|UniProtKB=Q8NEG5 Q8NEG5 ZSWIM2 PTHR21540:SF3 RING FINGER AND SWIM DOMAIN-CONTAINING PROTEIN 2 E3 UBIQUITIN-PROTEIN LIGASE ZSWIM2 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=14379|UniProtKB=O95170 O95170 FBXW10B PTHR19872:SF10 UBIQUITIN LIGASE SPECIFICITY FACTOR/HREP PROTEIN F-BOX AND WD REPEAT DOMAIN CONTAINING PROTEIN 10B-RELATED ubiquitin-protein ligase#PC00234 HUMAN|HGNC=30125|UniProtKB=Q8WU39 Q8WU39 MZB1 PTHR15881:SF2 MARGINAL ZONE B- AND B1-CELL-SPECIFIC PROTEIN MARGINAL ZONE B- AND B1-CELL-SPECIFIC PROTEIN positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of immune effector process#GO:0002697;regulation of macromolecule metabolic process#GO:0060255;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;positive regulation of immune effector process#GO:0002699;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of immune system process#GO:0002684 endoplasmic reticulum protein-containing complex#GO:0140534;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;extracellular region#GO:0005576;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 HUMAN|HGNC=7468|UniProtKB=Q99707 Q99707 MTR PTHR45833:SF1 METHIONINE SYNTHASE METHIONINE SYNTHASE catalytic activity#GO:0003824;transferase activity#GO:0016740;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741 amino acid biosynthetic process#GO:0008652;metabolic process#GO:0008152;small molecule biosynthetic process#GO:0044283;proteinogenic amino acid biosynthetic process#GO:0170038;sulfur compound metabolic process#GO:0006790;cellular process#GO:0009987;aspartate family amino acid biosynthetic process#GO:0009067;proteinogenic amino acid metabolic process#GO:0170039;amino acid metabolic process#GO:0006520;biosynthetic process#GO:0009058;oxoacid metabolic process#GO:0043436;tetrahydrofolate metabolic process#GO:0046653;carboxylic acid metabolic process#GO:0019752;modified amino acid metabolic process#GO:0006575;primary metabolic process#GO:0044238;carboxylic acid biosynthetic process#GO:0046394;pteridine-containing compound metabolic process#GO:0042558;folic acid-containing compound metabolic process#GO:0006760;small molecule metabolic process#GO:0044281 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 S-adenosylmethionine biosynthesis#P02773>Cobalamin-dependent homocysteine transmethylase#P03142;Formyltetrahydrofolate biosynthesis#P02743>Cobalamin dependent homocysteine transmethylase#P02953;Methionine biosynthesis#P02753>Homocysteine transmethylase#P03024 HUMAN|HGNC=26026|UniProtKB=Q9NX45 Q9NX45 SOHLH2 PTHR16223:SF415 TRANSCRIPTION FACTOR BHLH83-RELATED SPERMATOGENESIS- AND OOGENESIS-SPECIFIC BASIC HELIX-LOOP-HELIX-CONTAINING PROTEIN 2 double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;cellular process#GO:0009987;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;developmental process#GO:0032502;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 basic helix-loop-helix transcription factor#PC00055;DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=19152|UniProtKB=Q96M98 Q96M98 PACRG PTHR21207:SF7 PARKIN COREGULATED GENE PROTEIN PARK2 COREGULATED PARKIN COREGULATED GENE PROTEIN heat shock protein binding#GO:0031072;Hsp90 protein binding#GO:0051879;protein-folding chaperone binding#GO:0051087;binding#GO:0005488;Hsp70 protein binding#GO:0030544;protein binding#GO:0005515 cytosol#GO:0005829;neuron projection#GO:0043005;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=21529|UniProtKB=Q9HD45 Q9HD45 TM9SF3 PTHR10766:SF41 TRANSMEMBRANE 9 SUPERFAMILY PROTEIN TRANSMEMBRANE 9 SUPERFAMILY MEMBER 3 protein localization to membrane#GO:0072657;macromolecule localization#GO:0033036;cellular process#GO:0009987;localization within membrane#GO:0051668;cellular localization#GO:0051641;localization#GO:0051179;intracellular protein localization#GO:0008104 membrane#GO:0016020;cellular anatomical structure#GO:0110165 transporter#PC00227 HUMAN|HGNC=13705|UniProtKB=Q14656 Q14656 TMEM187 PTHR15066:SF0 TRANSMEMBRANE PROTEIN 187 TRANSMEMBRANE PROTEIN 187 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;transport vesicle#GO:0030133;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 HUMAN|HGNC=53847|UniProtKB=A0A1W2PPE2 A0A1W2PPE2 TAF11L4 PTHR13218:SF18 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11-RELATED TATA-BOX-BINDING PROTEIN-ASSOCIATED FACTOR 11-LIKE PROTEIN 10-RELATED macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;transcription initiation at RNA polymerase II promoter#GO:0006367;biosynthetic process#GO:0009058;protein-DNA complex assembly#GO:0065004;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;cellular component assembly#GO:0022607;transcription by RNA polymerase II#GO:0006366;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;protein-containing complex organization#GO:0043933;protein-DNA complex organization#GO:0071824;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-containing complex assembly#GO:0065003;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;RNA polymerase II preinitiation complex assembly#GO:0051123;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;DNA-templated transcription initiation#GO:0006352;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070 organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;RNA polymerase II, holoenzyme#GO:0016591;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;membrane-bounded organelle#GO:0043227;RNA polymerase II transcription regulator complex#GO:0090575;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;transcription factor TFIID complex#GO:0005669;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;transcription regulator complex#GO:0005667 general transcription factor#PC00259;RNA metabolism protein#PC00031 HUMAN|HGNC=25959|UniProtKB=Q9NXP7 Q9NXP7 GIN1 PTHR47266:SF6 ENDONUCLEASE-RELATED GYPSY RETROTRANSPOSON INTEGRASE-LIKE PROTEIN 1 HUMAN|HGNC=53786|UniProtKB=A0A1B0GUA9 A0A1B0GUA9 C13orf46 PTHR39223:SF1 RIKEN CDNA 1700029H14 GENE 1700029H14RIK PROTEIN HUMAN|HGNC=10898|UniProtKB=Q15477 Q15477 SKIC2 PTHR12131:SF34 ATP-DEPENDENT RNA AND DNA HELICASE SUPERKILLER COMPLEX PROTEIN 2 ATP-dependent activity#GO:0140657;macromolecular conformation isomerase activity#GO:0120543;catalytic activity#GO:0003824;nucleic acid conformation isomerase activity#GO:0120545;RNA helicase activity#GO:0003724;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on RNA#GO:0140098;isomerase activity#GO:0016853;helicase activity#GO:0004386 regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay#GO:0000184;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;negative regulation of cellular process#GO:0048523;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;nucleic acid catabolic process#GO:0141188;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;RNA metabolic process#GO:0016070;RNA catabolic process#GO:0006401;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;negative regulation of gene expression#GO:0010629 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 DNA metabolism protein#PC00009 HUMAN|HGNC=26746|UniProtKB=Q7Z6I8 Q7Z6I8 C5orf24 PTHR31894:SF0 UPF0461 PROTEIN C5ORF24 UPF0461 PROTEIN C5ORF24 HUMAN|HGNC=17702|UniProtKB=Q9H9S3 Q9H9S3 SEC61A2 PTHR10906:SF10 SECY/SEC61-ALPHA FAMILY MEMBER PROTEIN TRANSPORT PROTEIN SEC61 SUBUNIT ALPHA ISOFORM 2 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;binding#GO:0005488;protein-containing complex binding#GO:0044877;ribosome binding#GO:0043022;ribonucleoprotein complex binding#GO:0043021;transmembrane protein transporter activity#GO:0008320 localization within membrane#GO:0051668;protein transport#GO:0015031;post-translational protein targeting to membrane, translocation#GO:0031204;cellular localization#GO:0051641;transmembrane transport#GO:0055085;localization#GO:0051179;protein targeting#GO:0006605;post-translational protein targeting to endoplasmic reticulum membrane#GO:0006620;transport#GO:0006810;protein transmembrane transport#GO:0071806;intracellular protein transport#GO:0006886;SRP-dependent cotranslational protein targeting to membrane#GO:0006614;intracellular transport#GO:0046907;protein targeting to membrane#GO:0006612;protein targeting to ER#GO:0045047;intracellular protein localization#GO:0008104;intracellular protein transmembrane transport#GO:0065002;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;macromolecule localization#GO:0033036;establishment of protein localization to membrane#GO:0090150;establishment of protein localization to endoplasmic reticulum#GO:0072599 organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;endoplasmic reticulum protein-containing complex#GO:0140534;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;rough endoplasmic reticulum membrane#GO:0030867;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;rough endoplasmic reticulum#GO:0005791;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;membrane protein complex#GO:0098796 transporter#PC00227 HUMAN|HGNC=19703|UniProtKB=Q6PHR2 Q6PHR2 ULK3 PTHR24348:SF65 SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED SERINE_THREONINE-PROTEIN KINASE ULK3 phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 regulation of catabolic process#GO:0009894;autophagosome assembly#GO:0000045;cellular component organization or biogenesis#GO:0071840;mitophagy#GO:0000423;metabolic process#GO:0008152;autophagy of mitochondrion#GO:0000422;biological regulation#GO:0065007;macroautophagy#GO:0016236;cellular component assembly#GO:0022607;autophagy#GO:0006914;cellular process#GO:0009987;autophagosome organization#GO:1905037;organelle organization#GO:0006996;response to nutrient levels#GO:0031667;cellular component biogenesis#GO:0044085;regulation of metabolic process#GO:0019222;response to stress#GO:0006950;reticulophagy#GO:0061709;vacuole organization#GO:0007033;process utilizing autophagic mechanism#GO:0061919;organelle assembly#GO:0070925;piecemeal microautophagy of the nucleus#GO:0034727;response to stimulus#GO:0050896;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of autophagy#GO:0010506;response to starvation#GO:0042594;cellular component organization#GO:0016043 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;vacuole#GO:0005773;cellular anatomical structure#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;phagophore assembly site#GO:0000407;autophagosome#GO:0005776 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=15634|UniProtKB=Q9BXR5 Q9BXR5 TLR10 PTHR24365:SF23 TOLL-LIKE RECEPTOR TOLL-LIKE RECEPTOR 10 binding#GO:0005488;signaling receptor binding#GO:0005102;lipid binding#GO:0008289;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;protein binding#GO:0005515 immune response-activating signaling pathway#GO:0002757;positive regulation of response to external stimulus#GO:0032103;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;cellular process#GO:0009987;positive regulation of immune system process#GO:0002684;regulation of response to external stimulus#GO:0032101;immune system process#GO:0002376;regulation of biological process#GO:0050789;immune response-regulating signaling pathway#GO:0002764;toll-like receptor signaling pathway#GO:0002224;signaling#GO:0023052;response to stimulus#GO:0050896;positive regulation of immune response#GO:0050778;positive regulation of defense response#GO:0031349;regulation of response to stimulus#GO:0048583;regulation of response to stress#GO:0080134;positive regulation of response to biotic stimulus#GO:0002833;pattern recognition receptor signaling pathway#GO:0002221;regulation of innate immune response#GO:0045088;positive regulation of innate immune response#GO:0045089;activation of innate immune response#GO:0002218;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;regulation of immune response#GO:0050776;regulation of defense response#GO:0031347;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;innate immune response-activating signaling pathway#GO:0002758;regulation of response to biotic stimulus#GO:0002831;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 Toll receptor signaling pathway#P00054>TLR#P01346 HUMAN|HGNC=24075|UniProtKB=Q86WK7 Q86WK7 AMIGO3 PTHR24368:SF62 AMPHOTERIN-INDUCED PROTEIN AMPHOTERIN-INDUCED PROTEIN 3 multicellular organism development#GO:0007275;anatomical structure development#GO:0048856;animal organ development#GO:0048513;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502;cell adhesion#GO:0007155;central nervous system development#GO:0007417;brain development#GO:0007420;multicellular organismal process#GO:0032501;head development#GO:0060322;nervous system development#GO:0007399;cell-cell adhesion#GO:0098609;cellular process#GO:0009987;heterophilic cell-cell adhesion#GO:0007157 cellular anatomical structure#GO:0110165;membrane#GO:0016020 HUMAN|HGNC=16932|UniProtKB=O76041 O76041 NEBL PTHR11039:SF48 NEBULIN NEBULETTE binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;actin filament binding#GO:0051015;protein binding#GO:0005515;protein-containing complex binding#GO:0044877 anatomical structure formation involved in morphogenesis#GO:0048646;striated muscle cell differentiation#GO:0051146;animal organ development#GO:0048513;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;striated muscle tissue development#GO:0014706;cellular anatomical entity morphogenesis#GO:0032989;cardiac muscle cell differentiation#GO:0055007;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;heart development#GO:0007507;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;striated muscle cell development#GO:0055002;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;actomyosin structure organization#GO:0031032;cell differentiation#GO:0030154;circulatory system development#GO:0072359;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;actin filament organization#GO:0007015;cellular developmental process#GO:0048869;cardiac muscle tissue development#GO:0048738;developmental process#GO:0032502;multicellular organismal process#GO:0032501;tissue development#GO:0009888;system development#GO:0048731;supramolecular fiber organization#GO:0097435;muscle tissue development#GO:0060537;anatomical structure development#GO:0048856;actin filament-based process#GO:0030029;cellular component assembly involved in morphogenesis#GO:0010927;organelle assembly#GO:0070925;muscle structure development#GO:0061061;actin cytoskeleton organization#GO:0030036;muscle cell differentiation#GO:0042692;myofibril assembly#GO:0030239;muscle cell development#GO:0055001 intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;organelle#GO:0043226;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;contractile muscle fiber#GO:0043292;Z disc#GO:0030018;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;sarcomere#GO:0030017;membraneless organelle#GO:0043228;myofibril#GO:0030016;intracellular organelle#GO:0043229;I band#GO:0031674 HUMAN|HGNC=24645|UniProtKB=Q5FWF5 Q5FWF5 ESCO1 PTHR45884:SF1 N-ACETYLTRANSFERASE ECO N-ACETYLTRANSFERASE ESCO1 acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;protein N-acetyltransferase activity#GO:0034212;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein N-acyltransferase activity#GO:0140186;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;protein-lysine-acetyltransferase activity#GO:0061733;acetyltransferase activity#GO:0016407 cellular component organization or biogenesis#GO:0071840;sister chromatid cohesion#GO:0007062;chromosome organization#GO:0051276;mitotic sister chromatid cohesion#GO:0007064;organelle organization#GO:0006996;cell cycle#GO:0007049;cellular component organization#GO:0016043;cell cycle process#GO:0022402;cellular process#GO:0009987 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;acetyltransferase#PC00038 HUMAN|HGNC=31022|UniProtKB=Q9BTL3 Q9BTL3 RAMAC PTHR48168:SF1 RNA GUANINE-7 METHYLTRANSFERASE-ACTIVATING SUBUNIT-LIKE (PSEUDOGENE)-RELATED RNA GUANINE-N7 METHYLTRANSFERASE ACTIVATING SUBUNIT-RELATED binding#GO:0005488;nucleic acid binding#GO:0003676;enzyme activator activity#GO:0008047;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;RNA binding#GO:0003723 gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187 intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=24854|UniProtKB=O95210 O95210 STBD1 PTHR15048:SF1 STARCH-BINDING DOMAIN-CONTAINING PROTEIN 1 STARCH-BINDING DOMAIN-CONTAINING PROTEIN 1 macroautophagy#GO:0016236;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;autophagy#GO:0006914;glycogen catabolic process#GO:0005980;energy derivation by oxidation of organic compounds#GO:0015980;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;transport#GO:0006810;generation of precursor metabolites and energy#GO:0006091;vacuolar transport#GO:0007034;macromolecule catabolic process#GO:0009057;intracellular transport#GO:0046907;metabolic process#GO:0008152;glucan catabolic process#GO:0009251;carbohydrate metabolic process#GO:0005975;polysaccharide metabolic process#GO:0005976;catabolic process#GO:0009056;polysaccharide catabolic process#GO:0000272;glucan metabolic process#GO:0044042;primary metabolic process#GO:0044238;glycogen metabolic process#GO:0005977;process utilizing autophagic mechanism#GO:0061919;cellular localization#GO:0051641;localization#GO:0051179;carbohydrate catabolic process#GO:0016052;energy reserve metabolic process#GO:0006112;lysosomal transport#GO:0007041 membrane#GO:0016020;cellular anatomical structure#GO:0110165 HUMAN|HGNC=1636|UniProtKB=P29017 P29017 CD1C PTHR16675:SF155 MHC CLASS I-RELATED T-CELL SURFACE GLYCOPROTEIN CD1C lipid binding#GO:0008289;antigen binding#GO:0003823;binding#GO:0005488 regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;positive regulation of leukocyte mediated immunity#GO:0002705;immune response#GO:0006955;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of immune system process#GO:0002684;positive regulation of immune effector process#GO:0002699;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;regulation of cell killing#GO:0031341;regulation of immune response#GO:0050776;regulation of lymphocyte mediated immunity#GO:0002706;immune system process#GO:0002376;regulation of leukocyte mediated cytotoxicity#GO:0001910;regulation of immune effector process#GO:0002697;antigen processing and presentation#GO:0019882;positive regulation of lymphocyte mediated immunity#GO:0002708;regulation of biological process#GO:0050789;regulation of leukocyte mediated immunity#GO:0002703;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;positive regulation of adaptive immune response#GO:0002821;response to stimulus#GO:0050896 extracellular region#GO:0005576;external side of plasma membrane#GO:0009897;side of membrane#GO:0098552;membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;plasma membrane#GO:0005886 major histocompatibility complex protein#PC00149;defense/immunity protein#PC00090 HUMAN|HGNC=5429|UniProtKB=P32881 P32881 IFNA8 PTHR11691:SF28 TYPE I INTERFERON INTERFERON ALPHA-8 protein-containing complex binding#GO:0044877;molecular function activator activity#GO:0140677;protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102;cytokine receptor binding#GO:0005126;cytokine activity#GO:0005125;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545 response to peptide#GO:1901652;cell activation involved in immune response#GO:0002263;immune system process#GO:0002376;B cell activation involved in immune response#GO:0002312;type I interferon-mediated signaling pathway#GO:0060337;response to stimulus#GO:0050896;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;T cell activation#GO:0042110;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;B cell activation#GO:0042113;humoral immune response#GO:0006959;leukocyte activation involved in immune response#GO:0002366;cell surface receptor signaling pathway#GO:0007166;natural killer cell activation#GO:0030101;immune effector process#GO:0002252;response to cytokine#GO:0034097;response to chemical#GO:0042221;lymphocyte activation#GO:0046649;defense response to other organism#GO:0098542;T cell activation involved in immune response#GO:0002286;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;signal transduction#GO:0007165;defense response to symbiont#GO:0140546;lymphocyte activation involved in immune response#GO:0002285;cellular process#GO:0009987;cell communication#GO:0007154;response to nitrogen compound#GO:1901698;cytokine-mediated signaling pathway#GO:0019221;cell activation#GO:0001775;regulation of cellular process#GO:0050794;response to external biotic stimulus#GO:0043207;leukocyte activation#GO:0045321;cellular response to stimulus#GO:0051716;innate immune response#GO:0045087;response to external stimulus#GO:0009605;defense response#GO:0006952;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;adaptive immune response#GO:0002250;response to other organism#GO:0051707;immune response#GO:0006955 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 interferon superfamily#PC00127;cytokine#PC00083 HUMAN|HGNC=7679|UniProtKB=Q92597 Q92597 NDRG1 PTHR11034:SF18 N-MYC DOWNSTREAM REGULATED PROTEIN NDRG1 cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 serine protease#PC00203 HUMAN|HGNC=2740|UniProtKB=Q92841 Q92841 DDX17 PTHR47958:SF215 ATP-DEPENDENT RNA HELICASE DBP3 ATP-DEPENDENT RNA HELICASE DDX17-RELATED RNA binding#GO:0003723;ATP-dependent activity#GO:0140657;mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;catalytic activity, acting on RNA#GO:0140098;isomerase activity#GO:0016853;helicase activity#GO:0004386;macromolecular conformation isomerase activity#GO:0120543;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;RNA helicase activity#GO:0003724;catalytic activity#GO:0003824 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170;alternative mRNA splicing, via spliceosome#GO:0000380 nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 RNA helicase#PC00032 HUMAN|HGNC=13829|UniProtKB=Q9GZT5 Q9GZT5 WNT10A PTHR12027:SF89 WNT RELATED PROTEIN WNT-10A molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;frizzled binding#GO:0005109;G protein-coupled receptor binding#GO:0001664;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;molecular function activator activity#GO:0140677;protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102;cytokine activity#GO:0005125 developmental process#GO:0032502;neuron differentiation#GO:0030182;cell surface receptor signaling pathway#GO:0007166;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;signal transduction#GO:0007165;cellular process#GO:0009987;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;nervous system development#GO:0007399;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;cell communication#GO:0007154;canonical Wnt signaling pathway#GO:0060070;anatomical structure development#GO:0048856;cell fate commitment#GO:0045165;system development#GO:0048731;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;cell differentiation#GO:0030154;Wnt signaling pathway#GO:0016055;regulation of cellular process#GO:0050794;signaling#GO:0023052 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 Cadherin signaling pathway#P00012>Wnt#P00474;Angiogenesis#P00005>Wnt#P00206;Alzheimer disease-presenilin pathway#P00004>Wnt#P00142;Wnt signaling pathway#P00057>Wnt#P01444 HUMAN|HGNC=12555|UniProtKB=Q16880 Q16880 UGT8 PTHR48043:SF54 EG:EG0003.4 PROTEIN-RELATED 2-HYDROXYACYLSPHINGOSINE 1-BETA-GALACTOSYLTRANSFERASE galactosyltransferase activity#GO:0008378;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740 glycolipid biosynthetic process#GO:0009247;ceramide metabolic process#GO:0006672;glycosphingolipid biosynthetic process#GO:0006688;liposaccharide metabolic process#GO:1903509;glycolipid metabolic process#GO:0006664;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;ceramide biosynthetic process#GO:0046513;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;sphingolipid metabolic process#GO:0006665;sphingolipid biosynthetic process#GO:0030148;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 HUMAN|HGNC=6261|UniProtKB=Q99712 Q99712 KCNJ15 PTHR11767:SF20 INWARD RECTIFIER POTASSIUM CHANNEL ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 15 voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;potassium channel activity#GO:0005267;ligand-gated monoatomic ion channel activity#GO:0015276 import across plasma membrane#GO:0098739;metal ion transport#GO:0030001;inorganic ion import across plasma membrane#GO:0099587;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;potassium ion transport#GO:0006813;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987;potassium ion import across plasma membrane#GO:1990573;import into cell#GO:0098657;establishment of localization#GO:0051234;inorganic cation import across plasma membrane#GO:0098659;transport#GO:0006810 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133 HUMAN|HGNC=29009|UniProtKB=Q6AHZ1 Q6AHZ1 ZNF518A PTHR24392:SF39 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 518A DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HUMAN|HGNC=8550|UniProtKB=Q9UQ80 Q9UQ80 PA2G4 PTHR10804:SF130 PROTEASE FAMILY M24 METHIONYL AMINOPEPTIDASE, AMINOPEPTIDASE P PROLIFERATION-ASSOCIATED PROTEIN 2G4 protease#PC00190 HUMAN|HGNC=26034|UniProtKB=Q9NX18 Q9NX18 SDHAF2 PTHR12469:SF2 PROTEIN EMI5 HOMOLOG, MITOCHONDRIAL SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 2, MITOCHONDRIAL protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;aerobic respiration#GO:0009060;cellular respiration#GO:0045333;oxidative phosphorylation#GO:0006119;ATP synthesis coupled electron transport#GO:0042773;aerobic electron transport chain#GO:0019646;mitochondrial respiratory chain complex II assembly#GO:0034553;mitochondrial respiratory chain complex assembly#GO:0033108;mitochondrion organization#GO:0007005;cellular component assembly#GO:0022607;cellular process#GO:0009987;respiratory electron transport chain#GO:0022904;mitochondrial ATP synthesis coupled electron transport#GO:0042775;tricarboxylic acid cycle#GO:0006099;electron transport chain#GO:0022900;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;protein-containing complex organization#GO:0043933;energy derivation by oxidation of organic compounds#GO:0015980;cellular component organization or biogenesis#GO:0071840;mitochondrial electron transport, succinate to ubiquinone#GO:0006121;generation of precursor metabolites and energy#GO:0006091;metabolic process#GO:0008152 mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=27067|UniProtKB=Q32P51 Q32P51 HNRNPA1L2 PTHR48026:SF30 HOMOLOGOUS TO DROSOPHILA SQD (SQUID) PROTEIN HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A1-LIKE 2 mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA 3'-UTR binding#GO:0003730;RNA binding#GO:0003723 RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 nucleus#GO:0005634;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;catalytic step 2 spliceosome#GO:0071013;nuclear protein-containing complex#GO:0140513 RNA metabolism protein#PC00031;RNA processing factor#PC00147 HUMAN|HGNC=5042|UniProtKB=P55795 P55795 HNRNPH2 PTHR13976:SF33 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN H2 binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255 intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 RNA processing factor#PC00147;RNA splicing factor#PC00148;RNA metabolism protein#PC00031 HUMAN|HGNC=27898|UniProtKB=Q3KNT9 Q3KNT9 TMEM95 PTHR38808:SF1 TRANSMEMBRANE PROTEIN 95 SPERM-EGG FUSION PROTEIN TMEM95 single fertilization#GO:0007338;cellular process#GO:0009987;fusion of sperm to egg plasma membrane involved in single fertilization#GO:0007342;reproductive process#GO:0022414;cellular process involved in reproduction in multicellular organism#GO:0022412;fertilization#GO:0009566;sexual reproduction#GO:0019953;multicellular organismal reproductive process#GO:0048609 acrosomal membrane#GO:0002080;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;cytoplasm#GO:0005737;membrane#GO:0016020;secretory vesicle#GO:0099503;vesicle membrane#GO:0012506;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;acrosomal vesicle#GO:0001669;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;secretory granule membrane#GO:0030667;intracellular vesicle#GO:0097708;vesicle#GO:0031982 HUMAN|HGNC=12630|UniProtKB=Q93009 Q93009 USP7 PTHR24006:SF761 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN C-TERMINAL HYDROLASE 7 hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;cysteine-type deubiquitinase activity#GO:0004843 regulation of protein stability#GO:0031647;biological regulation#GO:0065007;regulation of biological quality#GO:0065008 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;cytosol#GO:0005829 cysteine protease#PC00081;protease#PC00190 HUMAN|HGNC=32371|UniProtKB=Q6PEY1 Q6PEY1 TMEM88 PTHR28628:SF3 TRANSMEMBRANE PROTEIN 88-RELATED TRANSMEMBRANE PROTEIN 88 negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;negative regulation of response to stimulus#GO:0048585;negative regulation of Wnt signaling pathway#GO:0030178;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of canonical Wnt signaling pathway#GO:0060828;negative regulation of cell communication#GO:0010648;negative regulation of canonical Wnt signaling pathway#GO:0090090;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 HUMAN|HGNC=2499|UniProtKB=Q16619 Q16619 CTF1 PTHR21353:SF2 FAMILY NOT NAMED CARDIOTROPHIN-1 cytokine activity#GO:0005125;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772 animal gross anatomical part developmental process#GO:0160108;anatomical structure development#GO:0048856;cell communication#GO:0007154;system development#GO:0048731;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;cell surface receptor signaling pathway#GO:0007166;cell surface receptor signaling pathway via JAK-STAT#GO:0007259;developmental process#GO:0032502;multicellular organism development#GO:0007275;cellular process#GO:0009987;signal transduction#GO:0007165;multicellular organismal process#GO:0032501;cell surface receptor signaling pathway via STAT#GO:0097696;nervous system development#GO:0007399;biological regulation#GO:0065007 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=3579|UniProtKB=P16930 P16930 FAH PTHR43069:SF2 FUMARYLACETOACETASE FUMARYLACETOACETASE catalytic activity#GO:0003824;hydrolase activity#GO:0016787 oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;amino acid metabolic process#GO:0006520;small molecule catabolic process#GO:0044282;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;proteinogenic amino acid metabolic process#GO:0170039;monocarboxylic acid catabolic process#GO:0072329;carboxylic acid catabolic process#GO:0046395;phenol-containing compound metabolic process#GO:0018958;cellular process#GO:0009987;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752 HUMAN|HGNC=29885|UniProtKB=Q659A1 Q659A1 ICE2 PTHR14633:SF3 LITTLE ELONGATION COMPLEX SUBUNIT 2 LITTLE ELONGATION COMPLEX SUBUNIT 2 positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;snRNA transcription#GO:0009301;regulation of biological process#GO:0050789;transcription by RNA polymerase III#GO:0006383;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;positive regulation of macromolecule metabolic process#GO:0010604;gene expression#GO:0010467;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of biosynthetic process#GO:0009891;snRNA transcription by RNA polymerase III#GO:0042796;regulation of DNA-templated transcription#GO:0006355;snRNA metabolic process#GO:0016073;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;positive regulation of RNA metabolic process#GO:0051254;snRNA transcription by RNA polymerase II#GO:0042795;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;transcription by RNA polymerase II#GO:0006366;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;nucleobase-containing compound metabolic process#GO:0006139;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;biosynthetic process#GO:0009058;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;macromolecule biosynthetic process#GO:0009059 HUMAN|HGNC=28496|UniProtKB=Q7Z4H8 Q7Z4H8 POGLUT3 PTHR12203:SF18 KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED PROTEIN O-GLUCOSYLTRANSFERASE 3 glycosyltransferase activity#GO:0016757;glucosyltransferase activity#GO:0046527;catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 HUMAN|HGNC=11708|UniProtKB=P48775 P48775 TDO2 PTHR10138:SF0 TRYPTOPHAN 2,3-DIOXYGENASE TRYPTOPHAN 2,3-DIOXYGENASE oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen#GO:0016702;tetrapyrrole binding#GO:0046906;oxidoreductase activity#GO:0016491;dioxygenase activity#GO:0051213;heme binding#GO:0020037;catalytic activity#GO:0003824;binding#GO:0005488 metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;small molecule catabolic process#GO:0044282;amino acid metabolic process#GO:0006520;proteinogenic amino acid metabolic process#GO:0170039;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;indole-containing compound metabolic process#GO:0042430;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752 oxygenase#PC00177 HUMAN|HGNC=13658|UniProtKB=Q9HB63 Q9HB63 NTN4 PTHR10574:SF282 NETRIN/LAMININ-RELATED NETRIN-4 cellular developmental process#GO:0048869;neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;tissue development#GO:0009888;extracellular matrix assembly#GO:0085029;cell migration#GO:0016477;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;axon development#GO:0061564;axon guidance#GO:0007411;cell-substrate adhesion#GO:0031589;extracellular matrix organization#GO:0030198;anatomical structure development#GO:0048856;system development#GO:0048731;external encapsulating structure organization#GO:0045229;cell motility#GO:0048870;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cell projection morphogenesis#GO:0048858;neuron differentiation#GO:0030182;substrate adhesion-dependent cell spreading#GO:0034446;plasma membrane bounded cell projection morphogenesis#GO:0120039;cellular component assembly#GO:0022607;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;neuron projection development#GO:0031175;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;axonogenesis#GO:0007409;neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;extracellular structure organization#GO:0043062;cell adhesion#GO:0007155;generation of neurons#GO:0048699;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell morphogenesis#GO:0000902;cell development#GO:0048468;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653 extracellular region#GO:0005576;extracellular protein-containing complex#GO:0140392;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;supramolecular complex#GO:0099080;basement membrane#GO:0005604;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 extracellular matrix protein#PC00102 Axon guidance mediated by Slit/Robo#P00008>Netrin#P00344;Axon guidance mediated by netrin#P00009>Netrin#P00357;Integrin signalling pathway#P00034>Laminin#P00947 HUMAN|HGNC=16143|UniProtKB=Q9BTV7 Q9BTV7 CABLES2 PTHR22896:SF3 CDK5 AND ABL1 ENZYME SUBSTRATE 1 CDK5 AND ABL1 ENZYME SUBSTRATE 2 HUMAN|HGNC=2016|UniProtKB=Q9UQC9 Q9UQC9 CLCA2 PTHR10579:SF66 CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR 2 monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;chloride transmembrane transporter activity#GO:0015108;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;chloride channel activity#GO:0005254;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic anion transmembrane transporter activity#GO:0008509;monoatomic anion channel activity#GO:0005253;channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133 HUMAN|HGNC=26115|UniProtKB=Q9H790 Q9H790 EXO5 PTHR14464:SF4 EXONUCLEASE V EXONUCLEASE V hydrolase activity, acting on ester bonds#GO:0016788;DNA nuclease activity#GO:0004536;DNA exonuclease activity#GO:0004529;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on DNA#GO:0140097;exonuclease activity#GO:0004527;5'-3' exonuclease activity#GO:0008409;DNA exonuclease activity, producing 5'-phosphomonoesters#GO:0016895;nuclease activity#GO:0004518;hydrolase activity#GO:0016787 DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA damage response#GO:0006974;cellular response to stress#GO:0033554;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;response to stress#GO:0006950;nucleic acid metabolic process#GO:0090304;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139;interstrand cross-link repair#GO:0036297 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=18180|UniProtKB=Q9NZT1 Q9NZT1 CALML5 PTHR23050:SF224 CALCIUM BINDING PROTEIN CALMODULIN-LIKE PROTEIN 5 binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;calcium ion binding#GO:0005509;enzyme regulator activity#GO:0030234;metal ion binding#GO:0046872;cation binding#GO:0043169;molecular function regulator activity#GO:0098772 microtubule-based process#GO:0007017;cytoskeleton organization#GO:0007010;microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 calmodulin-related#PC00061;calcium-binding protein#PC00060 HUMAN|HGNC=5471|UniProtKB=P18065 P18065 IGFBP2 PTHR11551:SF5 INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 2 binding#GO:0005488;growth factor binding#GO:0019838;protein binding#GO:0005515 regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease inhibitor#PC00191;protein-binding activity modulator#PC00095 HUMAN|HGNC=38137|UniProtKB=P60608 P60608 ERVFC1-1 PTHR10424:SF73 VIRAL ENVELOPE PROTEIN ENDOGENOUS RETROVIRUS GROUP FC1 ENV POLYPROTEIN-RELATED muscle cell differentiation#GO:0042692;cellular process#GO:0009987;myoblast fusion#GO:0007520;cell differentiation#GO:0030154;muscle structure development#GO:0061061;developmental process#GO:0032502;cell-cell fusion#GO:0140253;animal gross anatomical part developmental process#GO:0160108;striated muscle cell differentiation#GO:0051146;syncytium formation by cell-cell fusion#GO:0000768;anatomical structure development#GO:0048856;cellular developmental process#GO:0048869 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 viral or transposable element protein#PC00237 HUMAN|HGNC=18669|UniProtKB=Q8N3R9 Q8N3R9 PALS1 PTHR23122:SF14 MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK PROTEIN PALS1 developmental process#GO:0032502;protein localization to cell periphery#GO:1990778;neurogenesis#GO:0022008;morphogenesis of an epithelium#GO:0002009;intracellular protein localization#GO:0008104;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;embryonic morphogenesis#GO:0048598;cellular process#GO:0009987;macromolecule localization#GO:0033036;embryo development#GO:0009790;nervous system development#GO:0007399;tissue development#GO:0009888;multicellular organismal process#GO:0032501;epithelium development#GO:0060429;establishment or maintenance of bipolar cell polarity#GO:0061245;localization within membrane#GO:0051668;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;establishment or maintenance of apical/basal cell polarity#GO:0035088;establishment or maintenance of cell polarity#GO:0007163;system development#GO:0048731;anatomical structure development#GO:0048856;cellular localization#GO:0051641;establishment or maintenance of epithelial cell apical/basal polarity#GO:0045197;tissue morphogenesis#GO:0048729;localization#GO:0051179;anatomical structure morphogenesis#GO:0009653;protein localization to plasma membrane#GO:0072659;protein localization to membrane#GO:0072657;cell differentiation#GO:0030154 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell-cell junction#GO:0005911;cell periphery#GO:0071944;cell junction#GO:0030054;anchoring junction#GO:0070161;adherens junction#GO:0005912 scaffold/adaptor protein#PC00226 HUMAN|HGNC=2934|UniProtKB=Q9Y5R6 Q9Y5R6 DMRT1 PTHR12322:SF70 DOUBLESEX AND MAB-3 RELATED TRANSCRIPTION FACTOR DMRT DOUBLESEX- AND MAB-3-RELATED TRANSCRIPTION FACTOR 1 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987 developmental process involved in reproduction#GO:0003006;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;reproductive process#GO:0022414;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;sex differentiation#GO:0007548;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218 HUMAN|HGNC=6862|UniProtKB=P27816 P27816 MAP4 PTHR11501:SF16 MICROTUBULE-ASSOCIATED PROTEIN MICROTUBULE-ASSOCIATED PROTEIN 4 protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;microtubule binding#GO:0008017;binding#GO:0005488 system development#GO:0048731;neuron development#GO:0048666;microtubule cytoskeleton organization#GO:0000226;anatomical structure development#GO:0048856;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;regulation of microtubule-based process#GO:0032886;cell development#GO:0048468;regulation of microtubule-based movement#GO:0060632;cell differentiation#GO:0030154;cell projection organization#GO:0030030;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;microtubule-based process#GO:0007017;neurogenesis#GO:0022008;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;neuron differentiation#GO:0030182;developmental process#GO:0032502;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection organization#GO:0120036;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;cellular process#GO:0009987;neuron projection development#GO:0031175;organelle organization#GO:0006996 intracellular organelle#GO:0043229;axon#GO:0030424;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;neuron projection#GO:0043005;microtubule cytoskeleton#GO:0015630;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165 microtubule or microtubule-binding cytoskeletal protein#PC00157;non-motor microtubule binding protein#PC00166 HUMAN|HGNC=25778|UniProtKB=Q2M296 Q2M296 MTHFSD PTHR13017:SF0 5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE-RELATED METHENYLTETRAHYDROFOLATE SYNTHASE DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;ligase#PC00142 HUMAN|HGNC=2621|UniProtKB=P33261 P33261 CYP2C19 PTHR24300:SF360 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 2C19 tetrapyrrole binding#GO:0046906;binding#GO:0005488;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen#GO:0016712;catalytic activity#GO:0003824;monooxygenase activity#GO:0004497;heme binding#GO:0020037;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705 olefinic compound metabolic process#GO:0120254;cellular response to chemical stimulus#GO:0070887;response to xenobiotic stimulus#GO:0009410;oxoacid metabolic process#GO:0043436;response to stimulus#GO:0050896;small molecule metabolic process#GO:0044281;xenobiotic metabolic process#GO:0006805;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;cellular response to stimulus#GO:0051716;arachidonate metabolic process#GO:0019369;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;unsaturated fatty acid metabolic process#GO:0033559;icosanoid metabolic process#GO:0006690;response to chemical#GO:0042221;cellular response to xenobiotic stimulus#GO:0071466;long-chain fatty acid metabolic process#GO:0001676;cellular process#GO:0009987 intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 oxidoreductase#PC00176;oxygenase#PC00177 HUMAN|HGNC=8824|UniProtKB=P36955 P36955 SERPINF1 PTHR11461:SF84 SERINE PROTEASE INHIBITOR, SERPIN PIGMENT EPITHELIUM-DERIVED FACTOR molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866;enzyme inhibitor activity#GO:0004857;serine-type endopeptidase inhibitor activity#GO:0004867;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;peptidase regulator activity#GO:0061134;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135 regulation of anatomical structure morphogenesis#GO:0022603;negative regulation of angiogenesis#GO:0016525;regulation of angiogenesis#GO:0045765;regulation of vasculature development#GO:1901342;biological regulation#GO:0065007;regulation of developmental process#GO:0050793;regulation of multicellular organismal process#GO:0051239;negative regulation of biological process#GO:0048519;negative regulation of multicellular organismal process#GO:0051241;regulation of biological process#GO:0050789;regulation of multicellular organismal development#GO:2000026 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease inhibitor#PC00191 HUMAN|HGNC=8947|UniProtKB=P19957 P19957 PI3 PTHR19441:SF30 WAP four-disulfide core domain protein ELAFIN molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866;enzyme inhibitor activity#GO:0004857;molecular function inhibitor activity#GO:0140678;serine-type endopeptidase inhibitor activity#GO:0004867;enzyme regulator activity#GO:0030234;peptidase regulator activity#GO:0061134;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135 response to other organism#GO:0051707;defense response to other organism#GO:0098542;immune response#GO:0006955;defense response to symbiont#GO:0140546;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;response to external stimulus#GO:0009605;defense response#GO:0006952;innate immune response#GO:0045087;antibacterial humoral response#GO:0019731;humoral immune response#GO:0006959;antimicrobial humoral response#GO:0019730;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to stimulus#GO:0050896;defense response to bacterium#GO:0042742;response to bacterium#GO:0009617;immune system process#GO:0002376 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HUMAN|HGNC=17852|UniProtKB=Q8WUD6 Q8WUD6 CHPT1 PTHR10414:SF32 ETHANOLAMINEPHOSPHOTRANSFERASE CHOLINEPHOSPHOTRANSFERASE 1 transferase#PC00220 HUMAN|Ensembl=ENSG00000284976.2|UniProtKB=A0A2R8Y4M4 A0A2R8Y4M4 LOC122513141 PTHR22791:SF3 RING-TYPE DOMAIN-CONTAINING PROTEIN E3 UBIQUITIN-PROTEIN LIGASE RNF182-RELATED ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824 cellular process#GO:0009987;protein modification by small protein conjugation#GO:0032446;protein modification process#GO:0036211;primary metabolic process#GO:0044238;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=14626|UniProtKB=Q96FF9 Q96FF9 CDCA5 PTHR31092:SF2 SORORIN SORORIN response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cell cycle process#GO:0022402;cell cycle#GO:0007049;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;sister chromatid cohesion#GO:0007062;cellular response to stress#GO:0033554;nucleobase-containing compound metabolic process#GO:0006139;mitotic sister chromatid cohesion#GO:0007064;cellular process#GO:0009987;organelle organization#GO:0006996;response to stress#GO:0006950;double-strand break repair#GO:0006302;chromosome organization#GO:0051276;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;DNA damage response#GO:0006974;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694 HUMAN|HGNC=14585|UniProtKB=Q96NX5 Q96NX5 CAMK1G PTHR24347:SF116 SERINE/THREONINE-PROTEIN KINASE CALCIUM_CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 1G calmodulin binding#GO:0005516;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;binding#GO:0005488;calcium/calmodulin-dependent protein kinase activity#GO:0004683;protein binding#GO:0005515;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 cell communication#GO:0007154;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=37239|UniProtKB=P0C851 P0C851 PIRT PTHR16100:SF4 PHOSPHOINOSITIDE-INTERACTING PROTEIN FAMILY MEMBER PHOSPHOINOSITIDE-INTERACTING PROTEIN ion binding#GO:0043167;binding#GO:0005488;anion binding#GO:0043168;small molecule binding#GO:0036094;transmembrane transporter binding#GO:0044325;phosphatidylinositol bisphosphate binding#GO:1902936;protein binding#GO:0005515 regulation of system process#GO:0044057;regulation of biological process#GO:0050789;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HUMAN|HGNC=3815|UniProtKB=Q12951 Q12951 FOXI1 PTHR11829:SF180 FORKHEAD BOX PROTEIN FORKHEAD BOX PROTEIN I1 RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;developmental process#GO:0032502;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;winged helix/forkhead transcription factor#PC00246;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=280|UniProtKB=P25100 P25100 ADRA1D PTHR24248:SF14 ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR ALPHA-1D ADRENERGIC RECEPTOR molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;G protein-coupled amine receptor activity#GO:0008227;transmembrane signaling receptor activity#GO:0004888 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;positive regulation of multicellular organismal process#GO:0051240;cell communication#GO:0007154;adrenergic receptor signaling pathway#GO:0071875;regulation of biological quality#GO:0065008;positive regulation of cytosolic calcium ion concentration#GO:0007204;G protein-coupled receptor signaling pathway#GO:0007186;circulatory system process#GO:0003013;phospholipase C-activating G protein-coupled receptor signaling pathway#GO:0007200;blood circulation#GO:0008015;multicellular organismal process#GO:0032501;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;regulation of multicellular organismal process#GO:0051239;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;system process#GO:0003008;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;regulation of anatomical structure size#GO:0090066;regulation of system process#GO:0044057;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021 Alpha adrenergic receptor signaling pathway#P00002>Alpha1A/1B/1C#P00078;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711 HUMAN|HGNC=32315|UniProtKB=Q5JR98 Q5JR98 DYNLT4 PTHR21255:SF55 T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN DYNEIN LIGHT CHAIN TCTEX-TYPE 4 binding#GO:0005488;protein binding#GO:0005515 microtubule-based movement#GO:0007018;microtubule-based process#GO:0007017;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;microtubule associated complex#GO:0005875;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;dynein complex#GO:0030286;microtubule cytoskeleton#GO:0015630;cytoplasmic dynein complex#GO:0005868 microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=9855|UniProtKB=P62834 P62834 RAP1A PTHR24070:SF395 RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY RAS-RELATED PROTEIN RAP-1A ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924 regulation of signaling#GO:0023051;response to oxygen-containing compound#GO:1901700;regulation of neurotransmitter transport#GO:0051588;cellular response to chemical stimulus#GO:0070887;regulation of secretion by cell#GO:1903530;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of synaptic vesicle exocytosis#GO:2000300;signaling#GO:0023052;regulation of neurotransmitter secretion#GO:0046928;response to stimulus#GO:0050896;regulation of localization#GO:0032879;regulation of transport#GO:0051049;cellular process#GO:0009987;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;intracellular signaling cassette#GO:0141124;regulation of trans-synaptic signaling#GO:0099177;response to chemical#GO:0042221;intracellular signal transduction#GO:0035556;regulation of exocytosis#GO:0017157;response to nitrogen compound#GO:1901698;cell communication#GO:0007154;regulation of secretion#GO:0051046;cellular response to stimulus#GO:0051716;regulation of cell communication#GO:0010646;modulation of chemical synaptic transmission#GO:0050804;regulation of cellular process#GO:0050794;negative regulation of transport#GO:0051051;negative regulation of cellular process#GO:0048523;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;cellular response to nitrogen compound#GO:1901699 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 small GTPase#PC00208 Integrin signalling pathway#P00034>Rap1#P00906;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Rap1#P00703;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Rap1#P00734 HUMAN|HGNC=24557|UniProtKB=Q9H8H0 Q9H8H0 NOL11 PTHR15633:SF3 NUCLEOLAR PROTEIN 11 NUCLEOLAR PROTEIN 11 cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;maturation of SSU-rRNA#GO:0030490;biosynthetic process#GO:0009058;metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;ribosomal small subunit biogenesis#GO:0042274;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364 membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 HUMAN|HGNC=16021|UniProtKB=Q9Y5N5 Q9Y5N5 HEMK2 PTHR45875:SF3 METHYLTRANSFERASE N6AMT1 METHYLTRANSFERASE HEMK2 transferase activity#GO:0016740;catalytic activity#GO:0003824;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;protein methyltransferase activity#GO:0008276;catalytic activity, acting on a protein#GO:0140096 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;methyltransferase complex#GO:0034708;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;transferase complex#GO:1990234 methyltransferase#PC00155 HUMAN|HGNC=6616|UniProtKB=P48059 P48059 LIMS1 PTHR24210:SF13 LIM DOMAIN-CONTAINING PROTEIN LIM AND SENESCENT CELL ANTIGEN-LIKE-CONTAINING DOMAIN PROTEIN 1 positive regulation of signaling#GO:0023056;cell adhesion#GO:0007155;regulation of signaling#GO:0023051;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;cell junction organization#GO:0034330;regulation of cell communication#GO:0010646;positive regulation of signal transduction#GO:0009967;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;cell-cell junction organization#GO:0045216;regulation of response to stimulus#GO:0048583;positive regulation of response to stimulus#GO:0048584;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;cell-cell adhesion#GO:0098609;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987 cell junction#GO:0030054;anchoring junction#GO:0070161;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;focal adhesion#GO:0005925;cell-substrate junction#GO:0030055;cell-cell junction#GO:0005911 cell junction protein#PC00070 Integrin signalling pathway#P00034>PINCH#P00921 HUMAN|HGNC=11389|UniProtKB=Q15831 Q15831 STK11 PTHR43895:SF181 CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED SERINE_THREONINE-PROTEIN KINASE STK11 kinase activator activity#GO:0019209;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein kinase activator activity#GO:0030295;catalytic activity, acting on a protein#GO:0140096;molecular function regulator activity#GO:0098772;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;enzyme regulator activity#GO:0030234;protein kinase activity#GO:0004672;molecular function activator activity#GO:0140677;transferase activity#GO:0016740;enzyme activator activity#GO:0008047;kinase activity#GO:0016301;protein kinase regulator activity#GO:0019887;kinase regulator activity#GO:0019207 cell communication#GO:0007154;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789 p53 pathway by glucose deprivation#P04397>LKB1#P04647 HUMAN|HGNC=7610|UniProtKB=Q99972 Q99972 MYOC PTHR23192:SF33 OLFACTOMEDIN-RELATED MYOCILIN osteoblast differentiation#GO:0001649;developmental process#GO:0032502;cell communication#GO:0007154;cellular developmental process#GO:0048869;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;cell differentiation#GO:0030154;ossification#GO:0001503;multicellular organismal process#GO:0032501;regulation of cellular process#GO:0050794 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;extracellular region#GO:0005576;Golgi apparatus#GO:0005794 structural protein#PC00211 HUMAN|HGNC=18129|UniProtKB=Q9UBU3 Q9UBU3 GHRL PTHR14122:SF1 GHRELIN PRECURSOR APPETITE-REGULATING HORMONE protein binding#GO:0005515;molecular function activator activity#GO:0140677;hormone activity#GO:0005179;signaling receptor binding#GO:0005102;binding#GO:0005488;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;G protein-coupled receptor binding#GO:0001664 positive regulation of developmental process#GO:0051094;regulation of response to stimulus#GO:0048583;positive regulation of synapse assembly#GO:0051965;positive regulation of cellular process#GO:0048522;response to nutrient levels#GO:0031667;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;regulation of synapse assembly#GO:0051963;positive regulation of hormone secretion#GO:0046887;regulation of cell junction assembly#GO:1901888;regulation of secretion#GO:0051046;regulation of synapse structure or activity#GO:0050803;regulation of nervous system development#GO:0051960;regulation of developmental process#GO:0050793;regulation of cell communication#GO:0010646;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of transport#GO:0051049;regulation of localization#GO:0032879;positive regulation of biological process#GO:0048518;positive regulation of secretion by cell#GO:1903532;positive regulation of transport#GO:0051050;regulation of multicellular organismal process#GO:0051239;positive regulation of cellular component biogenesis#GO:0044089;positive regulation of secretion#GO:0051047;positive regulation of cellular component organization#GO:0051130;regulation of synapse organization#GO:0050807;regulation of signaling#GO:0023051;regulation of biological quality#GO:0065008;regulation of secretion by cell#GO:1903530;regulation of hormone secretion#GO:0046883;positive regulation of signaling#GO:0023056;regulation of biological process#GO:0050789;regulation of hormone levels#GO:0010817;positive regulation of multicellular organismal process#GO:0051240;regulation of multicellular organismal development#GO:2000026;regulation of cellular component biogenesis#GO:0044087;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;positive regulation of nervous system development#GO:0051962 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 peptide hormone#PC00179 HUMAN|HGNC=26124|UniProtKB=Q8N3A8 Q8N3A8 PARP8 PTHR21328:SF3 POLY ADP-RIBOSE POLYMERASE FAMILY, MEMBER PARP PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP8 molecular function activator activity#GO:0140677;protein binding#GO:0005515;enzyme regulator activity#GO:0030234;enzyme binding#GO:0019899;NAD+ poly-ADP-ribosyltransferase activity#GO:0003950;binding#GO:0005488;kinase binding#GO:0019900;kinase regulator activity#GO:0019207;protein kinase regulator activity#GO:0019887;protein serine/threonine kinase activator activity#GO:0043539;enzyme activator activity#GO:0008047;transferase activity#GO:0016740;pentosyltransferase activity#GO:0016763;kinase activator activity#GO:0019209;molecular function regulator activity#GO:0098772;glycosyltransferase activity#GO:0016757;protein kinase activator activity#GO:0030295;catalytic activity#GO:0003824 biological regulation#GO:0065007;endoplasmic reticulum unfolded protein response#GO:0030968;response to stress#GO:0006950;signal transduction#GO:0007165;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;response to topologically incorrect protein#GO:0035966;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to unfolded protein#GO:0006986;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular response to unfolded protein#GO:0034620;response to endoplasmic reticulum stress#GO:0034976;cellular response to stress#GO:0033554;cellular response to topologically incorrect protein#GO:0035967 endoplasmic reticulum#GO:0005783;membrane#GO:0016020;endoplasmic reticulum tubular network#GO:0071782;nucleus#GO:0005634;endomembrane system#GO:0012505;nuclear envelope#GO:0005635;cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle envelope#GO:0031967;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=6005|UniProtKB=Q9HBE4 Q9HBE4 IL21 PTHR14356:SF2 INTERLEUKIN-15-RELATED INTERLEUKIN-21 positive regulation of biological process#GO:0048518;positive regulation of immune system process#GO:0002684;regulation of multicellular organismal process#GO:0051239;regulation of response to external stimulus#GO:0032101;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of response to external stimulus#GO:0032103;positive regulation of multicellular organismal process#GO:0051240;regulation of biological process#GO:0050789;regulation of cell killing#GO:0031341;regulation of lymphocyte mediated immunity#GO:0002706;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of innate immune response#GO:0045089;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of natural killer cell mediated cytotoxicity#GO:0045954;regulation of cytokine production#GO:0001817;positive regulation of immune effector process#GO:0002699;biological regulation#GO:0065007;regulation of natural killer cell mediated cytotoxicity#GO:0042269;positive regulation of response to stimulus#GO:0048584;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;positive regulation of defense response#GO:0031349;regulation of response to stress#GO:0080134;positive regulation of leukocyte mediated immunity#GO:0002705;regulation of gene expression#GO:0010468;positive regulation of response to biotic stimulus#GO:0002833;positive regulation of gene expression#GO:0010628;regulation of biosynthetic process#GO:0009889;regulation of innate immune response#GO:0045088;regulation of natural killer cell mediated immunity#GO:0002715;regulation of leukocyte mediated immunity#GO:0002703;regulation of response to biotic stimulus#GO:0002831;positive regulation of natural killer cell mediated immunity#GO:0002717;regulation of cellular process#GO:0050794;positive regulation of cytokine production#GO:0001819;regulation of immune system process#GO:0002682;regulation of macromolecule metabolic process#GO:0060255;regulation of defense response#GO:0031347;regulation of immune response#GO:0050776;regulation of leukocyte mediated cytotoxicity#GO:0001910;regulation of immune effector process#GO:0002697;positive regulation of biosynthetic process#GO:0009891;positive regulation of lymphocyte mediated immunity#GO:0002708 intercellular signal molecule#PC00207;cytokine#PC00083;interleukin superfamily#PC00128 Interleukin signaling pathway#P00036>Interleukin#P00970 HUMAN|HGNC=20406|UniProtKB=P48668 P48668 KRT6C PTHR45616:SF47 GATA-TYPE DOMAIN-CONTAINING PROTEIN KERATIN, TYPE II CYTOSKELETAL 6C structural molecule activity#GO:0005198 animal organ development#GO:0048513;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;developmental process#GO:0032502;epidermis development#GO:0008544;skin development#GO:0043588;cytoskeleton organization#GO:0007010;tissue development#GO:0009888;epithelial cell differentiation#GO:0030855;epidermal cell differentiation#GO:0009913;multicellular organismal process#GO:0032501;epithelium development#GO:0060429;cellular process#GO:0009987;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;anatomical structure development#GO:0048856;intermediate filament organization#GO:0045109;keratinocyte differentiation#GO:0030216;animal gross anatomical part developmental process#GO:0160108;intermediate filament-based process#GO:0045103;intermediate filament cytoskeleton organization#GO:0045104;cell differentiation#GO:0030154;cellular component organization#GO:0016043 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;intermediate filament#GO:0005882;supramolecular fiber#GO:0099512;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;organelle#GO:0043226;supramolecular complex#GO:0099080 HUMAN|HGNC=6161|UniProtKB=P18564 P18564 ITGB6 PTHR10082:SF11 INTEGRIN BETA SUBUNIT INTEGRIN BETA-6 protein binding#GO:0005515;protein-containing complex binding#GO:0044877;integrin binding#GO:0005178;signaling receptor binding#GO:0005102;binding#GO:0005488;cell adhesion molecule binding#GO:0050839 integrin-mediated signaling pathway#GO:0007229;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell motility#GO:0048870;signaling#GO:0023052;cell adhesion#GO:0007155;cell-matrix adhesion#GO:0007160;cell-substrate adhesion#GO:0031589;cell communication#GO:0007154;cell-cell adhesion#GO:0098609;signal transduction#GO:0007165;cellular process#GO:0009987;cell migration#GO:0016477;biological regulation#GO:0065007;cell adhesion mediated by integrin#GO:0033627;cell surface receptor signaling pathway#GO:0007166 signaling receptor complex#GO:0043235;anchoring junction#GO:0070161;cell junction#GO:0030054;integrin complex#GO:0008305;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;protein complex involved in cell adhesion#GO:0098636;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane#GO:0005886;focal adhesion#GO:0005925;cell-substrate junction#GO:0030055;cell surface#GO:0009986;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 integrin#PC00126 Integrin signalling pathway#P00034>Integrin beta#P00931 HUMAN|HGNC=8547|UniProtKB=O15460 O15460 P4HA2 PTHR10869:SF244 PROLYL 4-HYDROXYLASE ALPHA SUBUNIT PROLYL 4-HYDROXYLASE SUBUNIT ALPHA-2 2-oxoglutarate-dependent dioxygenase activity#GO:0016706;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491;dioxygenase activity#GO:0051213;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824 endoplasmic reticulum#GO:0005783;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum protein-containing complex#GO:0140534;oxidoreductase complex#GO:1990204;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 protein modifying enzyme#PC00260 HUMAN|HGNC=14333|UniProtKB=Q8WXS3 Q8WXS3 BAALC PTHR14731:SF0 BRAIN AND ACUTE LEUKEMIA CYTOPLASMIC PROTEIN BRAIN AND ACUTE LEUKEMIA CYTOPLASMIC PROTEIN cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=18328|UniProtKB=Q96NS1 Q96NS1 YPEL4 PTHR13848:SF17 PROTEIN YIPPEE-LIKE CG15309-RELATED PROTEIN YIPPEE-LIKE 4 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=8636|UniProtKB=P11498 P11498 PC PTHR43778:SF4 PYRUVATE CARBOXYLASE PYRUVATE CARBOXYLASE, MITOCHONDRIAL catalytic activity#GO:0003824;ligase activity#GO:0016874 glucose metabolic process#GO:0006006;small molecule biosynthetic process#GO:0044283;monosaccharide metabolic process#GO:0005996;metabolic process#GO:0008152;carbohydrate biosynthetic process#GO:0016051;biosynthetic process#GO:0009058;carbohydrate metabolic process#GO:0005975;monosaccharide biosynthetic process#GO:0046364;small molecule metabolic process#GO:0044281;cellular process#GO:0009987;gluconeogenesis#GO:0006094;hexose biosynthetic process#GO:0019319;primary metabolic process#GO:0044238;hexose metabolic process#GO:0019318 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 metabolite interconversion enzyme#PC00262;ligase#PC00142 Pyruvate metabolism#P02772>Pyruvate Carboxylase#P03140 HUMAN|HGNC=2946|UniProtKB=Q9UFH2 Q9UFH2 DNAH17 PTHR10676:SF284 DYNEIN HEAVY CHAIN FAMILY PROTEIN DYNEIN AXONEMAL HEAVY CHAIN 17 cytoskeletal motor activity#GO:0003774;isomerase activity#GO:0016853;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543;protein binding#GO:0005515;microtubule motor activity#GO:0003777;binding#GO:0005488;polypeptide conformation or assembly isomerase activity#GO:0120544;ATP-dependent activity#GO:0140657 cellular process#GO:0009987;cilium movement involved in cell motility#GO:0060294;microtubule-based movement#GO:0007018;cell motility#GO:0048870;cilium or flagellum-dependent cell motility#GO:0001539;cilium movement#GO:0003341;microtubule-based process#GO:0007017;cilium-dependent cell motility#GO:0060285 cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ciliary plasm#GO:0097014;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;cilium#GO:0005929;9+2 motile cilium#GO:0097729;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;axoneme#GO:0005930;dynein complex#GO:0030286;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;motile cilium#GO:0031514;organelle#GO:0043226 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=29573|UniProtKB=Q86SQ0 Q86SQ0 PHLDB2 PTHR12156:SF21 PLECKSTRIN HOMOLOGY-LIKE DOMAIN, FAMILY B, MEMBER 3 PLECKSTRIN HOMOLOGY-LIKE DOMAIN FAMILY B MEMBER 2 cellular component organization#GO:0016043;extracellular structure organization#GO:0043062;cellular process#GO:0009987;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;external encapsulating structure organization#GO:0045229 cell periphery#GO:0071944;cell cortex#GO:0005938;basal part of cell#GO:0045178;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 EGF receptor signaling pathway#P00018>Gab#P00563 HUMAN|HGNC=18|UniProtKB=Q13685 Q13685 AAMP PTHR19857:SF27 MITOCHONDRIAL DIVISION PROTEIN 1-RELATED ANGIO-ASSOCIATED MIGRATORY CELL PROTEIN molecular function regulator activity#GO:0098772;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234 cell motility#GO:0048870;cell migration#GO:0016477;cellular process#GO:0009987;cell adhesion#GO:0007155 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=20443|UniProtKB=O43312 O43312 MTSS1 PTHR15708:SF10 ACTIN BUNDLING/MISSING IN METASTASIS-RELATED PROTEIN MTSS 1 lipid binding#GO:0008289;protein binding#GO:0005515;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;phospholipid binding#GO:0005543;binding#GO:0005488 positive regulation of cellular component organization#GO:0051130;positive regulation of organelle organization#GO:0010638;regulation of supramolecular fiber organization#GO:1902903;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;regulation of actin filament bundle assembly#GO:0032231;adherens junction organization#GO:0034332;cellular component organization#GO:0016043;regulation of cellular component biogenesis#GO:0044087;regulation of cellular component organization#GO:0051128;cell projection organization#GO:0030030;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794;cell junction organization#GO:0034330;cell-cell junction organization#GO:0045216;regulation of actin filament-based process#GO:0032970;positive regulation of actin filament bundle assembly#GO:0032233;cellular component organization or biogenesis#GO:0071840;cell-cell junction maintenance#GO:0045217;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cell projection assembly#GO:0030031;regulation of actin filament organization#GO:0110053;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;membrane organization#GO:0061024;biological regulation#GO:0065007;regulation of actin cytoskeleton organization#GO:0032956;cellular component assembly#GO:0022607;positive regulation of cellular component biogenesis#GO:0044089 actin cytoskeleton#GO:0015629;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=16100|UniProtKB=Q5JX71 Q5JX71 FAM209A PTHR35157:SF1 PROTEIN FAM209A PROTEIN FAM209A HUMAN|HGNC=30187|UniProtKB=Q9NRX6 Q9NRX6 TMEM167B PTHR46815:SF1 PROTEIN KISH-B PROTEIN KISH-B HUMAN|HGNC=13941|UniProtKB=Q53GD3 Q53GD3 SLC44A4 PTHR12385:SF37 CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44) CHOLINE TRANSPORTER-LIKE PROTEIN 4 organophosphate ester transmembrane transporter activity#GO:0015605;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;quaternary ammonium group transmembrane transporter activity#GO:0015651 establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;transport#GO:0006810;vitamin transport#GO:0051180;organophosphate ester transport#GO:0015748;nitrogen compound transport#GO:0071705;quaternary ammonium group transport#GO:0015697;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227;secondary carrier transporter#PC00258 HUMAN|HGNC=17697|UniProtKB=Q9NP81 Q9NP81 SARS2 PTHR11778:SF23 SERYL-TRNA SYNTHETASE SERINE--TRNA LIGASE, MITOCHONDRIAL tRNA binding#GO:0000049;catalytic activity, acting on a tRNA#GO:0140101;RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;catalytic activity, acting on RNA#GO:0140098;ligase activity#GO:0016874;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 translation#GO:0006412;protein metabolic process#GO:0019538;RNA metabolic process#GO:0016070;mitochondrial RNA metabolic process#GO:0000959;mitochondrial gene expression#GO:0140053;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mitochondrial translation#GO:0032543;protein biosynthetic process#GO:0160307;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;amino acid activation#GO:0043038;macromolecule metabolic process#GO:0043170;tRNA aminoacylation#GO:0043039;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;tRNA aminoacylation for protein translation#GO:0006418;gene expression#GO:0010467;amino acid metabolic process#GO:0006520;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739 translational protein#PC00263;aminoacyl-tRNA synthetase#PC00047 HUMAN|HGNC=25233|UniProtKB=Q6P499 Q6P499 NIPAL3 PTHR12570:SF14 DUF803 DOMAIN MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07070)-RELATED NIPA-LIKE PROTEIN 3 magnesium ion transport#GO:0015693;transport#GO:0006810;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;metal ion transport#GO:0030001 cellular anatomical structure#GO:0110165;membrane#GO:0016020 secondary carrier transporter#PC00258 HUMAN|HGNC=10947|UniProtKB=Q08357 Q08357 SLC20A2 PTHR11101:SF83 PHOSPHATE TRANSPORTER SODIUM-DEPENDENT PHOSPHATE TRANSPORTER 2 solute:sodium symporter activity#GO:0015370;monoatomic cation transmembrane transporter activity#GO:0008324;symporter activity#GO:0015293;phosphate transmembrane transporter activity#GO:0005315;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291 cellular process#GO:0009987;transport#GO:0006810;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;phosphate ion transport#GO:0006817;inorganic anion transport#GO:0015698 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227 HUMAN|HGNC=25164|UniProtKB=Q96EG3 Q96EG3 ZNF837 PTHR24377:SF987 IP01015P-RELATED ZINC FINGER PROTEIN 837 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=18107|UniProtKB=P0DP74 P0DP74 DEFB130A PTHR20515:SF1 BETA-DEFENSIN BETA-DEFENSIN 130A-RELATED signaling receptor binding#GO:0005102;binding#GO:0005488;cytokine receptor binding#GO:0005126;protein binding#GO:0005515;chemokine receptor binding#GO:0042379;molecular function activator activity#GO:0140677;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;G protein-coupled receptor binding#GO:0001664;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546 biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;locomotion#GO:0040011;response to stimulus#GO:0050896;cell motility#GO:0048870;cellular response to stimulus#GO:0051716;cell chemotaxis#GO:0060326;chemotaxis#GO:0006935;defense response to bacterium#GO:0042742;response to bacterium#GO:0009617;cellular response to chemical stimulus#GO:0070887;response to other organism#GO:0051707;response to chemical#GO:0042221;taxis#GO:0042330;cell migration#GO:0016477;cellular process#GO:0009987;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;response to external stimulus#GO:0009605;defense response#GO:0006952 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090;antimicrobial response protein#PC00051 HUMAN|HGNC=16917|UniProtKB=Q15345 Q15345 LRRC41 PTHR15354:SF1 MUF1 LEUCINE-RICH REPEAT-CONTAINING PROTEIN 41 catalytic complex#GO:1902494;transferase complex#GO:1990234;Cul5-RING ubiquitin ligase complex#GO:0031466;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461 HUMAN|HGNC=22201|UniProtKB=Q9Y4C2 Q9Y4C2 TCAF1 PTHR15730:SF1 EXPERIMENTAL AUTOIMMUNE PROSTATITIS ANTIGEN 2-RELATED TRPM8 CHANNEL-ASSOCIATED FACTOR 1 transmembrane transporter binding#GO:0044325;binding#GO:0005488;protein binding#GO:0005515 positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789;positive regulation of cellular process#GO:0048522;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of protein localization#GO:0032880;regulation of localization#GO:0032879;regulation of establishment of protein localization#GO:0070201 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HUMAN|HGNC=9024|UniProtKB=Q99959 Q99959 PKP2 PTHR10372:SF25 PLAKOPHILLIN-RELATED PLAKOPHILIN-2 protein binding#GO:0005515;binding#GO:0005488;cell adhesion molecule binding#GO:0050839 intermediate filament organization#GO:0045109;cell adhesion#GO:0007155;animal gross anatomical part developmental process#GO:0160108;intermediate filament-based process#GO:0045103;cellular localization#GO:0051641;cellular component organization#GO:0016043;protein localization to membrane#GO:0072657;intermediate filament cytoskeleton organization#GO:0045104;circulatory system development#GO:0072359;intermediate filament bundle assembly#GO:0045110;protein localization to cell periphery#GO:1990778;animal organ development#GO:0048513;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cellular process#GO:0009987;cell-cell adhesion#GO:0098609;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;heart development#GO:0007507;cellular component assembly#GO:0022607;localization within membrane#GO:0051668;system development#GO:0048731;supramolecular fiber organization#GO:0097435;anatomical structure development#GO:0048856;localization#GO:0051179;protein localization to plasma membrane#GO:0072659;cell junction organization#GO:0034330;developmental process#GO:0032502;cell-cell junction organization#GO:0045216;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;multicellular organismal process#GO:0032501 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intercalated disc#GO:0014704;anchoring junction#GO:0070161;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;adherens junction#GO:0005912;cell-cell contact zone#GO:0044291;cell junction#GO:0030054;nucleus#GO:0005634;cell periphery#GO:0071944;cell-cell junction#GO:0005911;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737 intermediate filament binding protein#PC00130;intermediate filament#PC00129;cytoskeletal protein#PC00085 HUMAN|HGNC=30037|UniProtKB=Q96JA3 Q96JA3 PLEKHA8 PTHR10219:SF90 GLYCOLIPID TRANSFER PROTEIN-RELATED PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 8 transporter activity#GO:0005215;phospholipid binding#GO:0005543;lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;binding#GO:0005488;lipid transfer activity#GO:0120013;lipid binding#GO:0008289;phospholipid transfer activity#GO:0120014 intracellular transport#GO:0046907;transport#GO:0006810;establishment of localization#GO:0051234;intermembrane lipid transfer#GO:0120009;cellular component organization or biogenesis#GO:0071840;nitrogen compound transport#GO:0071705;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;lipid transport#GO:0006869;membrane organization#GO:0061024;lipid localization#GO:0010876;cellular localization#GO:0051641;localization#GO:0051179;cellular component organization#GO:0016043;ceramide transport#GO:0035627 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;membrane#GO:0016020;cytosol#GO:0005829 transfer/carrier protein#PC00219 HUMAN|HGNC=11387|UniProtKB=P31948 P31948 STIP1 PTHR22904:SF517 TPR REPEAT CONTAINING PROTEIN STRESS-INDUCED-PHOSPHOPROTEIN 1 Hsp90 protein binding#GO:0051879;heat shock protein binding#GO:0031072;binding#GO:0005488;protein binding#GO:0005515 HUMAN|HGNC=3704|UniProtKB=Q13643 Q13643 FHL3 PTHR24205:SF5 FOUR AND A HALF LIM DOMAINS PROTEIN FOUR AND A HALF LIM DOMAINS PROTEIN 3 transcription cofactor#PC00217 HUMAN|HGNC=2865|UniProtKB=O43323 O43323 DHH PTHR11889:SF56 HEDGEHOG DESERT HEDGEHOG PROTEIN cation binding#GO:0043169;protein binding#GO:0005515;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;signaling receptor binding#GO:0005102;binding#GO:0005488 cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;cell fate commitment#GO:0045165;smoothened signaling pathway#GO:0007224;cell communication#GO:0007154;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;cell surface receptor signaling pathway#GO:0007166;cell fate specification#GO:0001708;developmental process#GO:0032502;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HUMAN|HGNC=13937|UniProtKB=O95866 O95866 MPIG6B PTHR37347:SF1 MEGAKARYOCYTE AND PLATELET INHIBITORY RECEPTOR G6B MEGAKARYOCYTE AND PLATELET INHIBITORY RECEPTOR G6B biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of cell adhesion#GO:0007162;regulation of coagulation#GO:0050818;multicellular organismal process#GO:0032501;negative regulation of response to stimulus#GO:0048585;regulation of cell adhesion#GO:0030155;regulation of hemostasis#GO:1900046;response to wounding#GO:0009611;negative regulation of wound healing#GO:0061045;blood coagulation#GO:0007596;negative regulation of cell activation#GO:0050866;regulation of response to stimulus#GO:0048583;regulation of response to stress#GO:0080134;negative regulation of cellular process#GO:0048523;negative regulation of blood coagulation#GO:0030195;regulation of cell communication#GO:0010646;regulation of cell-cell adhesion#GO:0022407;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;negative regulation of multicellular organismal process#GO:0051241;hemostasis#GO:0007599;cell communication#GO:0007154;regulation of platelet activation#GO:0010543;negative regulation of response to external stimulus#GO:0032102;negative regulation of signal transduction#GO:0009968;regulation of multicellular organismal process#GO:0051239;negative regulation of cell-cell adhesion#GO:0022408;regulation of response to external stimulus#GO:0032101;signal transduction#GO:0007165;coagulation#GO:0050817;cellular process#GO:0009987;regulation of response to wounding#GO:1903034;response to stress#GO:0006950;negative regulation of response to wounding#GO:1903035;cell surface receptor signaling pathway#GO:0007166;signaling#GO:0023052;regulation of wound healing#GO:0061041;response to stimulus#GO:0050896;regulation of blood coagulation#GO:0030193;regulation of body fluid levels#GO:0050878;regulation of biological process#GO:0050789;regulation of cell activation#GO:0050865;negative regulation of biological process#GO:0048519;integrin-mediated signaling pathway#GO:0007229;wound healing#GO:0042060;regulation of biological quality#GO:0065008;negative regulation of cell communication#GO:0010648;negative regulation of coagulation#GO:0050819;regulation of signaling#GO:0023051;negative regulation of hemostasis#GO:1900047;negative regulation of signaling#GO:0023057;regulation of platelet aggregation#GO:0090330 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=10778|UniProtKB=Q6FHJ7 Q6FHJ7 SFRP4 PTHR11309:SF7 FRIZZLED SECRETED FRIZZLED-RELATED PROTEIN 4 transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488;signaling receptor activity#GO:0038023;protein binding#GO:0005515;molecular transducer activity#GO:0060089;Wnt-protein binding#GO:0017147 cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;canonical Wnt signaling pathway#GO:0060070;non-canonical Wnt signaling pathway#GO:0035567;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;Wnt signaling pathway#GO:0016055;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;membrane#GO:0016020;cell periphery#GO:0071944;extracellular region#GO:0005576 transmembrane signal receptor#PC00197 Wnt signaling pathway#P00057>FrzB#P01461 HUMAN|HGNC=19167|UniProtKB=Q9P2E2 Q9P2E2 KIF17 PTHR24115:SF1046 KINESIN-RELATED KINESIN-LIKE PROTEIN KIF17 tubulin binding#GO:0015631;macromolecular conformation isomerase activity#GO:0120543;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;isomerase activity#GO:0016853;ribonucleoside triphosphate phosphatase activity#GO:0017111;microtubule binding#GO:0008017;polypeptide conformation or assembly isomerase activity#GO:0120544;ATP hydrolysis activity#GO:0016887;microtubule motor activity#GO:0003777;hydrolase activity#GO:0016787;cytoskeletal protein binding#GO:0008092;hydrolase activity, acting on acid anhydrides#GO:0016817;cytoskeletal motor activity#GO:0003774;ATP-dependent activity#GO:0140657;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;plus-end-directed microtubule motor activity#GO:0008574;protein binding#GO:0005515 cellular component organization#GO:0016043;microtubule-based movement#GO:0007018;cell projection organization#GO:0030030;microtubule-based transport#GO:0099111;cellular localization#GO:0051641;localization#GO:0051179;axo-dendritic transport#GO:0008088;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;cytoskeleton-dependent intracellular transport#GO:0030705;intracellular transport#GO:0046907;transport#GO:0006810;transport along microtubule#GO:0010970;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017 cilium#GO:0005929;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;neuron projection#GO:0043005;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;microtubule associated complex#GO:0005875 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=16212|UniProtKB=Q9H1Q7 Q9H1Q7 PCED1A PTHR14469:SF3 SARCOMA ANTIGEN NY-SAR-23 PC-ESTERASE DOMAIN-CONTAINING PROTEIN 1A HUMAN|HGNC=27424|UniProtKB=Q5T481 Q5T481 RBM20 PTHR15592:SF11 MATRIN 3/NUCLEAR PROTEIN 220-RELATED RNA-BINDING PROTEIN 20 mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 RNA processing factor#PC00147 HUMAN|HGNC=31926|UniProtKB=P0C7V9 P0C7V9 METTL15P1 PTHR11265:SF1 S-ADENOSYL-METHYLTRANSFERASE MRAW 12S RRNA N(4)-CYTIDINE METHYLTRANSFERASE METTL15-RELATED N-methyltransferase activity#GO:0008170;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;catalytic activity, acting on a rRNA#GO:0140102;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity#GO:0003824;transferase activity#GO:0016740;RNA methyltransferase activity#GO:0008173;rRNA methyltransferase activity#GO:0008649;catalytic activity, acting on RNA#GO:0140098 cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;rRNA methylation#GO:0031167;metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;rRNA base methylation#GO:0070475;cellular component biogenesis#GO:0044085;rRNA processing#GO:0006364;methylation#GO:0032259;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;RNA methylation#GO:0001510;nucleic acid biosynthetic process#GO:0141187;macromolecule methylation#GO:0043414;RNA modification#GO:0009451;ribosome biogenesis#GO:0042254;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;rRNA modification#GO:0000154;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 methyltransferase#PC00155;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=25548|UniProtKB=Q9NVR2 Q9NVR2 INTS10 PTHR16055:SF2 INTEGRATOR COMPLEX SUBUNIT 10 INTEGRATOR COMPLEX SUBUNIT 10 nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;snRNA processing#GO:0016180;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;nucleic acid biosynthetic process#GO:0141187;snRNA metabolic process#GO:0016073;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;integrator complex#GO:0032039;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634 HUMAN|HGNC=14560|UniProtKB=Q9UBI4 Q9UBI4 STOML1 PTHR10264:SF130 BAND 7 PROTEIN-RELATED STOMATIN-LIKE PROTEIN 1 molecular function inhibitor activity#GO:0140678;molecular function regulator activity#GO:0098772;channel regulator activity#GO:0016247;ion channel inhibitor activity#GO:0008200;ion channel regulator activity#GO:0099106;transporter regulator activity#GO:0141108 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 cytoskeletal protein#PC00085 HUMAN|HGNC=7618|UniProtKB=O14974 O14974 PPP1R12A PTHR24179:SF20 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12A phosphatase regulator activity#GO:0019208;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;molecular function inhibitor activity#GO:0140678;protein phosphatase regulator activity#GO:0019888;enzyme inhibitor activity#GO:0004857 cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell morphogenesis#GO:0000902;cell development#GO:0048468;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;anatomical structure development#GO:0048856;system development#GO:0048731;neuron development#GO:0048666;neuron projection development#GO:0031175;cellular process#GO:0009987;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;nervous system development#GO:0007399;neuron differentiation#GO:0030182;developmental process#GO:0032502;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron projection morphogenesis#GO:0048812;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;cell projection morphogenesis#GO:0048858;neurogenesis#GO:0022008 membraneless organelle#GO:0043228;sarcomere#GO:0030017;I band#GO:0031674;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;Z disc#GO:0030018;contractile muscle fiber#GO:0043292;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;myofibril#GO:0030016;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;A band#GO:0031672 protein-binding activity modulator#PC00095;phosphatase modulator#PC00184 HUMAN|HGNC=26011|UniProtKB=Q9NX95 Q9NX95 SYBU PTHR16208:SF4 MICROTUBULE-ASSOCIATED PROTEIN/SYNTAPHILIN SYNTABULIN axo-dendritic transport#GO:0008088;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;cytoskeleton-dependent intracellular transport#GO:0030705;multicellular organismal process#GO:0032501;developmental maturation#GO:0021700;organelle transport along microtubule#GO:0072384;nervous system development#GO:0007399;intracellular transport#GO:0046907;transport#GO:0006810;developmental process#GO:0032502;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;mitochondrion localization#GO:0051646;cellular component organization#GO:0016043;cell junction organization#GO:0034330;establishment of organelle localization#GO:0051656;microtubule-based movement#GO:0007018;animal gross anatomical part developmental process#GO:0160108;organelle localization#GO:0051640;axonal transport#GO:0098930;synapse organization#GO:0050808;microtubule-based transport#GO:0099111;anatomical structure development#GO:0048856;cellular localization#GO:0051641;localization#GO:0051179;system development#GO:0048731 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;microtubule cytoskeleton#GO:0015630;cytoplasmic microtubule#GO:0005881;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;organelle#GO:0043226;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081 SNARE protein#PC00034 HUMAN|HGNC=25458|UniProtKB=O43934 O43934 MFSD11 PTHR23294:SF0 ET TRANSLATION PRODUCT-RELATED UNC93-LIKE PROTEIN MFSD11 HUMAN|HGNC=26629|UniProtKB=Q86TJ5 Q86TJ5 ZNF554 PTHR24381:SF56 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 554 DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=2678|UniProtKB=P14868 P14868 DARS1 PTHR43450:SF1 ASPARTYL-TRNA SYNTHETASE ASPARTATE--TRNA LIGASE, CYTOPLASMIC binding#GO:0005488;nucleic acid binding#GO:0003676;catalytic activity, acting on a tRNA#GO:0140101;RNA binding#GO:0003723;ligase activity#GO:0016874;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;catalytic activity, acting on RNA#GO:0140098 protein biosynthetic process#GO:0160307;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;protein metabolic process#GO:0019538;translation#GO:0006412;gene expression#GO:0010467;amino acid metabolic process#GO:0006520;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;tRNA aminoacylation#GO:0043039;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;tRNA aminoacylation for protein translation#GO:0006418;amino acid activation#GO:0043038;macromolecule metabolic process#GO:0043170;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;cytoplasm#GO:0005737;cytosol#GO:0005829;catalytic complex#GO:1902494 aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 HUMAN|HGNC=25147|UniProtKB=Q8NCI6 Q8NCI6 GLB1L3 PTHR23421:SF59 BETA-GALACTOSIDASE RELATED BETA-GALACTOSIDASE-1-LIKE PROTEIN 3 hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 carbohydrate catabolic process#GO:0016052;metabolic process#GO:0008152;monosaccharide metabolic process#GO:0005996;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;carbohydrate metabolic process#GO:0005975;small molecule catabolic process#GO:0044282;hexose metabolic process#GO:0019318;primary metabolic process#GO:0044238;cellular process#GO:0009987 galactosidase#PC00104;hydrolase#PC00121 HUMAN|Gene=YD019_HUMAN|UniProtKB=Q6ZRP5 Q6ZRP5 PTHR45134:SF5 OS08G0543275 PROTEIN G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN HUMAN|HGNC=15518|UniProtKB=Q9UJW0 Q9UJW0 DCTN4 PTHR13034:SF2 DYNACTIN P62 SUBUNIT DYNACTIN SUBUNIT 4 establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;cellular process#GO:0009987;transport#GO:0006810;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;actin cytoskeleton#GO:0015629;microtubule cytoskeleton#GO:0015630 microtubule binding motor protein#PC00156 HUMAN|HGNC=12964|UniProtKB=Q9Y473 Q9Y473 ZNF175 PTHR24377:SF37 IP01015P-RELATED ZINC FINGER PROTEIN 175 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=13213|UniProtKB=Q7Z4Y8 Q7Z4Y8 ATP5MGL PTHR12386:SF12 ATP SYNTHASE SUBUNIT ATP SYNTHASE F(0) COMPLEX SUBUNIT G, MITOCHONDRIAL-RELATED transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;ligase activity#GO:0016874;passive transmembrane transporter activity#GO:0022803;catalytic activity#GO:0003824;proton transmembrane transporter activity#GO:0015078;proton channel activity#GO:0015252;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261;proton-transporting ATP synthase activity, rotational mechanism#GO:0046933;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324 small molecule metabolic process#GO:0044281;proton motive force-driven mitochondrial ATP synthesis#GO:0042776;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;ribonucleotide metabolic process#GO:0009259;ribose phosphate metabolic process#GO:0019693;ATP metabolic process#GO:0046034;cellular process#GO:0009987;ribose phosphate biosynthetic process#GO:0046390;nucleobase-containing small molecule metabolic process#GO:0055086;ribonucleoside triphosphate biosynthetic process#GO:0009201;carbohydrate derivative biosynthetic process#GO:1901137;ATP biosynthetic process#GO:0006754;metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing compound biosynthetic process#GO:0034654;proton motive force-driven ATP synthesis#GO:0015986;nucleoside phosphate metabolic process#GO:0006753;nucleoside triphosphate metabolic process#GO:0009141;purine nucleoside triphosphate biosynthetic process#GO:0009145;purine nucleoside triphosphate metabolic process#GO:0009144;primary metabolic process#GO:0044238;aerobic respiration#GO:0009060;oxidative phosphorylation#GO:0006119;organophosphate biosynthetic process#GO:0090407;cellular respiration#GO:0045333;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;purine ribonucleoside triphosphate biosynthetic process#GO:0009206;carbohydrate derivative metabolic process#GO:1901135;purine ribonucleoside triphosphate metabolic process#GO:0009205;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;nucleoside triphosphate biosynthetic process#GO:0009142;nucleoside phosphate biosynthetic process#GO:1901293;energy derivation by oxidation of organic compounds#GO:0015980;generation of precursor metabolites and energy#GO:0006091 membrane#GO:0016020;respiratory chain complex#GO:0098803;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;cytoplasm#GO:0005737;cation channel complex#GO:0034703;proton-transporting two-sector ATPase complex#GO:0016469;transporter complex#GO:1990351;membrane protein complex#GO:0098796;mitochondrion#GO:0005739;proton-transporting ATP synthase complex#GO:0045259;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transmembrane transporter complex#GO:1902495;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 ATP synthase#PC00002 HUMAN|HGNC=26082|UniProtKB=Q5R3I4 Q5R3I4 TTC38 PTHR16263:SF4 TETRATRICOPEPTIDE REPEAT PROTEIN 38 TETRATRICOPEPTIDE REPEAT PROTEIN 38 HUMAN|HGNC=10987|UniProtKB=O43808 O43808 SLC25A17 PTHR45939:SF5 PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED PEROXISOMAL MEMBRANE PROTEIN PMP34 purine nucleotide transmembrane transporter activity#GO:0015216;carbohydrate derivative transmembrane transporter activity#GO:1901505;nucleobase-containing compound transmembrane transporter activity#GO:0015932;organophosphate ester transmembrane transporter activity#GO:0015605;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;peroxisomal membrane#GO:0005778;microbody#GO:0042579;peroxisome#GO:0005777;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=22195|UniProtKB=Q76N89 Q76N89 HECW1 PTHR11254:SF79 HECT DOMAIN UBIQUITIN-PROTEIN LIGASE E3 UBIQUITIN-PROTEIN LIGASE HECW1 ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740 ubiquitin-dependent protein catabolic process#GO:0006511;regulation of anatomical structure morphogenesis#GO:0022603;regulation of plasma membrane bounded cell projection organization#GO:0120035;macromolecule metabolic process#GO:0043170;macromolecule catabolic process#GO:0009057;regulation of cell projection organization#GO:0031344;metabolic process#GO:0008152;biological regulation#GO:0065007;cellular process#GO:0009987;regulation of neuron projection development#GO:0010975;protein metabolic process#GO:0019538;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;regulation of dendrite development#GO:0050773;regulation of cellular component organization#GO:0051128;catabolic process#GO:0009056;modification-dependent protein catabolic process#GO:0019941;regulation of biological process#GO:0050789;primary metabolic process#GO:0044238;regulation of dendrite morphogenesis#GO:0048814 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=4555|UniProtKB=P22352 P22352 GPX3 PTHR11592:SF32 GLUTATHIONE PEROXIDASE GLUTATHIONE PEROXIDASE 3 antioxidant activity#GO:0016209;peroxidase activity#GO:0004601;binding#GO:0005488;small molecule binding#GO:0036094;catalytic activity#GO:0003824;oxidoreductase activity, acting on peroxide as acceptor#GO:0016684;oxidoreductase activity#GO:0016491 hydrogen peroxide metabolic process#GO:0042743;cellular response to oxidative stress#GO:0034599;catabolic process#GO:0009056;response to stimulus#GO:0050896;response to chemical#GO:0042221;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stress#GO:0006950;response to oxidative stress#GO:0006979;cellular response to chemical stress#GO:0062197;cellular response to stress#GO:0033554;reactive oxygen species metabolic process#GO:0072593;metabolic process#GO:0008152;cellular response to chemical stimulus#GO:0070887 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 oxidoreductase#PC00176;peroxidase#PC00180 HUMAN|HGNC=33179|UniProtKB=A6NMX2 A6NMX2 EIF4E1B PTHR11960:SF3 EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TYPE 1B translation factor activity#GO:0180051;nucleic acid binding#GO:0003676;binding#GO:0005488;translation initiation factor activity#GO:0003743;RNA binding#GO:0003723 protein biosynthetic process#GO:0160307;gene expression#GO:0010467;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;translational initiation#GO:0006413;translation#GO:0006412 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular protein-containing complex#GO:0140535;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 HUMAN|HGNC=30883|UniProtKB=Q8IUX1 Q8IUX1 TMEM126B PTHR16296:SF3 UNCHARACTERIZED HYPOTHALAMUS PROTEIN HT007 COMPLEX I ASSEMBLY FACTOR TMEM126B, MITOCHONDRIAL cellular component assembly#GO:0022607;mitochondrion organization#GO:0007005;mitochondrial respiratory chain complex assembly#GO:0033108;cellular component organization#GO:0016043;mitochondrial respiratory chain complex I assembly#GO:0032981;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;NADH dehydrogenase complex assembly#GO:0010257 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=13848|UniProtKB=Q9NR11 Q9NR11 ZNF302 PTHR24377:SF710 IP01015P-RELATED ZINC FINGER PROTEIN 181-RELATED DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=32203|UniProtKB=Q5H8A3 Q5H8A3 NMS PTHR32414:SF2 NEUROMEDIN-S NEUROMEDIN-S HUMAN|HGNC=19348|UniProtKB=Q9NYM9 Q9NYM9 BET1L PTHR12791:SF37 GOLGI SNARE BET1-RELATED BET1-LIKE PROTEIN protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;SNAP receptor activity#GO:0005484 localization#GO:0051179;cellular localization#GO:0051641;regulation of cellular process#GO:0050794;cytosolic transport#GO:0016482;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;establishment of localization#GO:0051234;regulation of transport#GO:0051049;regulation of localization#GO:0032879;endosomal transport#GO:0016197;intracellular transport#GO:0046907;transport#GO:0006810;vesicle-mediated transport#GO:0016192;biological regulation#GO:0065007;retrograde transport, endosome to Golgi#GO:0042147;establishment of localization in cell#GO:0051649;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;SNARE complex#GO:0031201;cellular anatomical structure#GO:0110165;membrane protein complex#GO:0098796;membrane#GO:0016020 SNARE protein#PC00034 HUMAN|HGNC=3762|UniProtKB=Q9NZU0 Q9NZU0 FLRT3 PTHR45712:SF12 AGAP008170-PA LEUCINE-RICH REPEAT TRANSMEMBRANE PROTEIN FLRT3 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=2763|UniProtKB=P12838 P12838 DEFA4 PTHR11876:SF23 ALPHA-DEFENSIN 1 DEFENSIN ALPHA 4 response to stress#GO:0006950;response to biotic stimulus#GO:0009607;defense response to symbiont#GO:0140546;immune response#GO:0006955;defense response to other organism#GO:0098542;response to other organism#GO:0051707;antimicrobial humoral response#GO:0019730;humoral immune response#GO:0006959;antibacterial humoral response#GO:0019731;innate immune response#GO:0045087;defense response#GO:0006952;response to external stimulus#GO:0009605;defense response to Gram-positive bacterium#GO:0050830;response to stimulus#GO:0050896;defense response to Gram-negative bacterium#GO:0050829;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;immune system process#GO:0002376;response to bacterium#GO:0009617;defense response to bacterium#GO:0042742;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 antimicrobial response protein#PC00051 HUMAN|HGNC=8739|UniProtKB=Q9UKZ9 Q9UKZ9 PCOLCE2 PTHR24251:SF31 OVOCHYMASE-RELATED PROCOLLAGEN C-ENDOPEPTIDASE ENHANCER 2 molecular function regulator activity#GO:0098772;peptidase activator activity#GO:0016504;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;protein-containing complex binding#GO:0044877;enzyme regulator activity#GO:0030234;peptidase regulator activity#GO:0061134;collagen binding#GO:0005518;binding#GO:0005488 protease#PC00190;serine protease#PC00203 HUMAN|HGNC=26879|UniProtKB=Q8N7P1 Q8N7P1 PLD5 PTHR10185:SF9 PHOSPHOLIPASE D - RELATED INACTIVE PHOSPHOLIPASE D5 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 phospholipase#PC00186 HUMAN|HGNC=25790|UniProtKB=Q7L8L6 Q7L8L6 FASTKD5 PTHR21228:SF70 FAST LEU-RICH DOMAIN-CONTAINING NON-CANONICAL PRE-MRNAS ENDONUCLEASE FASTKD5, MITOCHONDRIAL RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of RNA stability#GO:0043487;mitochondrial gene expression#GO:0140053;regulation of RNA metabolic process#GO:0051252;mitochondrial RNA metabolic process#GO:0000959;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;post-transcriptional regulation of gene expression#GO:0010608;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;macromolecule biosynthetic process#GO:0009059;mitochondrial RNA processing#GO:0000963;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;regulation of nucleobase-containing compound metabolic process#GO:0019219;nucleic acid biosynthetic process#GO:0141187;regulation of biological quality#GO:0065008;RNA metabolic process#GO:0016070;regulation of biological process#GO:0050789;regulation of mRNA catabolic process#GO:0061013;regulation of mRNA stability#GO:0043488;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;regulation of mRNA metabolic process#GO:1903311;cellular process#GO:0009987;RNA processing#GO:0006396;gene expression#GO:0010467 membraneless organelle#GO:0043228;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;membrane-enclosed lumen#GO:0031974;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;organelle lumen#GO:0043233 RNA processing factor#PC00147 HUMAN|HGNC=8993|UniProtKB=P12273 P12273 PIP PTHR15096:SF5 PROLACTIN-INDUCIBLE PROTEIN/SEMINAL VESICLE ANTIGEN PROLACTIN-INDUCIBLE PROTEIN peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;aspartic-type endopeptidase activity#GO:0004190;catalytic activity#GO:0003824 primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;cellular process#GO:0009987;regulation of immune system process#GO:0002682;biological regulation#GO:0065007;metabolic process#GO:0008152;proteolysis#GO:0006508;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=13906|UniProtKB=Q14582 Q14582 MXD4 PTHR11969:SF4 MAX DIMERIZATION, MAD MAX DIMERIZATION PROTEIN 4 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 basic helix-loop-helix transcription factor#PC00055;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=17902|UniProtKB=Q9GZQ3 Q9GZQ3 COMMD5 PTHR15666:SF3 COMM DOMAIN CONTAINING PROTEIN 5 COMM DOMAIN-CONTAINING PROTEIN 5 protein complex scaffold activity#GO:0140378;structural molecule activity#GO:0005198 protein-containing complex#GO:0032991 protein-binding activity modulator#PC00095 HUMAN|HGNC=14550|UniProtKB=Q96JP9 Q96JP9 CDHR1 PTHR24028:SF263 CADHERIN-87A CADHERIN-RELATED FAMILY MEMBER 1 cellular process#GO:0009987;cell adhesion#GO:0007155 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 cell adhesion molecule#PC00069;cadherin#PC00057 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HUMAN|HGNC=4528|UniProtKB=Q96P69 Q96P69 GPR78 PTHR24245:SF7 G-PROTEIN COUPLED RECEPTOR G PROTEIN-COUPLED RECEPTOR 78 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089 adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=25585|UniProtKB=Q8N543 Q8N543 OGFOD1 PTHR12117:SF0 HISTONE ACETYLTRANSFERASE COMPLEX PROLYL 3-HYDROXYLASE OGFOD1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;dioxygenase activity#GO:0051213 post-transcriptional regulation of gene expression#GO:0010608;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;regulation of protein-containing complex disassembly#GO:0043244;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of cellular component organization#GO:0051128;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 histone modifying enzyme#PC00261;chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=23396|UniProtKB=Q5SRE7 Q5SRE7 PHYHD1 PTHR20883:SF15 PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1 PHYTANOYL-COA DIOXYGENASE DOMAIN-CONTAINING PROTEIN 1 oxygenase#PC00177;oxidoreductase#PC00176 HUMAN|HGNC=24313|UniProtKB=O95727 O95727 CRTAM PTHR47118:SF1 CYTOTOXIC AND REGULATORY T-CELL MOLECULE CYTOTOXIC AND REGULATORY T-CELL MOLECULE signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515 positive regulation of response to stimulus#GO:0048584;regulation of natural killer cell mediated cytotoxicity#GO:0042269;biological regulation#GO:0065007;positive regulation of immune effector process#GO:0002699;detection of stimulus#GO:0051606;positive regulation of natural killer cell mediated cytotoxicity#GO:0045954;positive regulation of cellular process#GO:0048522;positive regulation of innate immune response#GO:0045089;regulation of innate immune response#GO:0045088;positive regulation of response to biotic stimulus#GO:0002833;positive regulation of leukocyte mediated immunity#GO:0002705;regulation of response to stress#GO:0080134;positive regulation of defense response#GO:0031349;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of response to biotic stimulus#GO:0002831;positive regulation of natural killer cell mediated immunity#GO:0002717;regulation of leukocyte mediated immunity#GO:0002703;regulation of natural killer cell mediated immunity#GO:0002715;positive regulation of lymphocyte mediated immunity#GO:0002708;regulation of immune effector process#GO:0002697;regulation of leukocyte mediated cytotoxicity#GO:0001910;regulation of immune response#GO:0050776;regulation of defense response#GO:0031347;cell recognition#GO:0008037;regulation of response to external stimulus#GO:0032101;response to biotic stimulus#GO:0009607;positive regulation of immune system process#GO:0002684;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of response to external stimulus#GO:0032103;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;regulation of lymphocyte mediated immunity#GO:0002706;regulation of cell killing#GO:0031341 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HUMAN|HGNC=18555|UniProtKB=Q9BX93 Q9BX93 PLA2G12B PTHR12824:SF2 GROUP XII SECRETORY PHOSPHOLIPASE A2 FAMILY MEMBER GROUP XIIB SECRETORY PHOSPHOLIPASE A2-LIKE PROTEIN chemical homeostasis#GO:0048878;lipid homeostasis#GO:0055088;triglyceride homeostasis#GO:0070328;homeostatic process#GO:0042592;cholesterol homeostasis#GO:0042632 phospholipase#PC00186;lipase#PC00143;hydrolase#PC00121 HUMAN|HGNC=22404|UniProtKB=Q8NHV1 Q8NHV1 GIMAP7 PTHR10903:SF199 GTPASE, IMAP FAMILY MEMBER-RELATED GTPASE IMAP FAMILY MEMBER 7 ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924 small GTPase#PC00208 HUMAN|HGNC=25430|UniProtKB=Q8IYG6 Q8IYG6 LRRC56 PTHR22708:SF0 LEUCINE-RICH REPEAT-CONTAINING PROTEIN 56 LEUCINE-RICH REPEAT-CONTAINING PROTEIN 56 HUMAN|HGNC=16465|UniProtKB=Q96J88 Q96J88 EPSTI1 PTHR22529:SF1 EPITHELIAL-STROMAL INTERACTION PROTEIN 1 EPITHELIAL-STROMAL INTERACTION PROTEIN 1 defense response#GO:0006952;macrophage activation#GO:0042116;inflammatory response#GO:0006954;cell activation#GO:0001775;immune system process#GO:0002376;myeloid leukocyte activation#GO:0002274;response to stimulus#GO:0050896;multicellular organismal process#GO:0032501;cellular process#GO:0009987;leukocyte activation#GO:0045321;response to stress#GO:0006950 HUMAN|HGNC=2303|UniProtKB=P16870 P16870 CPE PTHR11532:SF92 PROTEASE M14 CARBOXYPEPTIDASE CARBOXYPEPTIDASE E metallopeptidase activity#GO:0008237;hydrolase activity#GO:0016787;metallocarboxypeptidase activity#GO:0004181;exopeptidase activity#GO:0008238;carboxypeptidase activity#GO:0004180;catalytic activity#GO:0003824;metalloexopeptidase activity#GO:0008235;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233 protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467;metabolic process#GO:0008152;proteolysis#GO:0006508;peptide metabolic process#GO:0006518;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease#PC00190 Vasopressin synthesis#P04395>Exopeptidase#P04592;CCKR signaling map#P06959>Carboxypeptidase E#P07026 HUMAN|HGNC=26152|UniProtKB=Q9H6T0 Q9H6T0 ESRP2 PTHR13976:SF30 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED EPITHELIAL SPLICING REGULATORY PROTEIN 2 nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;RNA binding#GO:0003723 regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974 RNA splicing factor#PC00148;RNA metabolism protein#PC00031;RNA processing factor#PC00147 HUMAN|HGNC=28996|UniProtKB=Q92541 Q92541 RTF1 PTHR13115:SF8 RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG binding#GO:0005488;enzyme binding#GO:0019899;RNA polymerase binding#GO:0070063;RNA polymerase II complex binding#GO:0000993;protein binding#GO:0005515;RNA polymerase core enzyme binding#GO:0043175 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of RNA biosynthetic process#GO:2001141;chromatin organization#GO:0006325;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;cellular component organization#GO:0016043 transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;RNA polymerase II, holoenzyme#GO:0016591;membrane-bounded organelle#GO:0043227;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;transcription elongation factor complex#GO:0008023;intracellular membrane-bounded organelle#GO:0043231;Cdc73/Paf1 complex#GO:0016593;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;membrane-enclosed lumen#GO:0031974;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;protein-containing complex#GO:0032991 HUMAN|HGNC=5323|UniProtKB=Q2M3T9 Q2M3T9 HYAL4 PTHR11769:SF7 HYALURONIDASE HYALURONIDASE-4 catalytic activity#GO:0003824;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798 catabolic process#GO:0009056;carbohydrate derivative catabolic process#GO:1901136;glycosaminoglycan metabolic process#GO:0030203;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;aminoglycan catabolic process#GO:0006026;aminoglycan metabolic process#GO:0006022;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;glycosaminoglycan catabolic process#GO:0006027 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708 glycosidase#PC00110 HUMAN|HGNC=1645|UniProtKB=P25063 P25063 CD24 PTHR16676:SF0 SIGNAL TRANSDUCER CD24 SIGNAL TRANSDUCER CD24 protein kinase regulator activity#GO:0019887;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047;protein kinase activator activity#GO:0030295;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;kinase activator activity#GO:0019209 cell activation#GO:0001775;regulation of cellular process#GO:0050794;regulation of cell-cell adhesion#GO:0022407;regulation of cell adhesion#GO:0030155;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;regulation of biological process#GO:0050789;cellular process#GO:0009987 external side of plasma membrane#GO:0009897;membrane microdomain#GO:0098857;side of membrane#GO:0098552;membrane#GO:0016020;membrane raft#GO:0045121;cell periphery#GO:0071944;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HUMAN|HGNC=34349|UniProtKB=A6NCI8 A6NCI8 C2orf78 PTHR31466:SF1 GENE 5591-RELATED RIKEN CDNA 4930433I11 GENE HUMAN|HGNC=10833|UniProtKB=Q9Y371 Q9Y371 SH3GLB1 PTHR14167:SF52 SH3 DOMAIN-CONTAINING ENDOPHILIN-B1 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 scaffold/adaptor protein#PC00226 HUMAN|HGNC=14418|UniProtKB=Q9BW60 Q9BW60 ELOVL1 PTHR11157:SF19 FATTY ACID ACYL TRANSFERASE-RELATED VERY LONG CHAIN FATTY ACID ELONGASE 1 acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746 small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;sphingolipid metabolic process#GO:0006665;fatty acid metabolic process#GO:0006631;sphingolipid biosynthetic process#GO:0030148;monocarboxylic acid biosynthetic process#GO:0072330;cellular process#GO:0009987;fatty acid biosynthetic process#GO:0006633;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;oxoacid metabolic process#GO:0043436;carboxylic acid biosynthetic process#GO:0046394;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;very long-chain fatty acid metabolic process#GO:0000038;small molecule metabolic process#GO:0044281 organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020 transferase#PC00220;acyltransferase#PC00042 HUMAN|HGNC=44208|UniProtKB=Q6UX82 Q6UX82 LYPD8 PTHR20914:SF2 LY6/PLAUR DOMAIN-CONTAINING PROTEIN 8 LY6_PLAUR DOMAIN-CONTAINING PROTEIN 8 response to bacterium#GO:0009617;defense response to bacterium#GO:0042742;response to external stimulus#GO:0009605;defense response#GO:0006952;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;defense response to Gram-negative bacterium#GO:0050829;response to external biotic stimulus#GO:0043207;response to other organism#GO:0051707 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 scaffold/adaptor protein#PC00226 HUMAN|HGNC=22226|UniProtKB=Q96JH8 Q96JH8 RADIL PTHR16027:SF3 DILUTE DOMAIN-CONTAINING PROTEIN YPR089W RAS-ASSOCIATING AND DILUTE DOMAIN-CONTAINING PROTEIN binding#GO:0005488;enzyme binding#GO:0019899;protein binding#GO:0005515 cell-substrate adhesion#GO:0031589;anatomical structure development#GO:0048856;stem cell development#GO:0048864;animal gross anatomical part developmental process#GO:0160108;cell adhesion#GO:0007155;cell differentiation#GO:0030154;cell motility#GO:0048870;cell development#GO:0048468;animal organ development#GO:0048513;cellular developmental process#GO:0048869;mesenchyme development#GO:0060485;neural crest cell differentiation#GO:0014033;developmental process#GO:0032502;substrate adhesion-dependent cell spreading#GO:0034446;mesenchymal cell differentiation#GO:0048762;neural crest cell development#GO:0014032;tissue development#GO:0009888;cell migration#GO:0016477;stem cell differentiation#GO:0048863;neural crest cell migration#GO:0001755;cellular process#GO:0009987 membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630 HUMAN|Ensembl=ENSG00000277836.1|UniProtKB=A0AAG2SVT6 A0AAG2SVT6 PTHR23266:SF298 IMMUNOGLOBULIN HEAVY CHAIN IG-LIKE DOMAIN-CONTAINING PROTEIN antigen binding#GO:0003823;binding#GO:0005488 immune response#GO:0006955;response to stimulus#GO:0050896;adaptive immune response#GO:0002250;immune system process#GO:0002376;immune effector process#GO:0002252;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=16403|UniProtKB=Q9UL40 Q9UL40 ZNF346 PTHR46144:SF5 ZINC FINGER PROTEIN 385B-LIKE ZINC FINGER PROTEIN 346 double-stranded RNA binding#GO:0003725;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 HUMAN|HGNC=40375|UniProtKB=H3BPM6 H3BPM6 MKRN2OS PTHR33963:SF2 MKRN2 OPPOSITE STRAND PROTEIN MKRN2 OPPOSITE STRAND PROTEIN HUMAN|HGNC=28750|UniProtKB=Q1EHB4 Q1EHB4 SLC5A12 PTHR42985:SF15 SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER 2 secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;monocarboxylic acid transmembrane transporter activity#GO:0008028;solute:monoatomic cation symporter activity#GO:0015294;monoatomic ion transmembrane transporter activity#GO:0015075;symporter activity#GO:0015293;carboxylic acid transmembrane transporter activity#GO:0046943;monoatomic cation transmembrane transporter activity#GO:0008324;solute:sodium symporter activity#GO:0015370 sodium ion transport#GO:0006814;transport#GO:0006810;localization#GO:0051179;monoatomic cation transport#GO:0006812;establishment of localization#GO:0051234;metal ion transport#GO:0030001;monoatomic ion transport#GO:0006811 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227;secondary carrier transporter#PC00258 HUMAN|HGNC=25126|UniProtKB=Q96HR8 Q96HR8 NAF1 PTHR31633:SF1 H/ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1 H_ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1 nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;cellular component assembly#GO:0022607;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;cellular component organization or biogenesis#GO:0071840;protein-RNA complex assembly#GO:0022618;protein-RNA complex organization#GO:0071826;protein-containing complex organization#GO:0043933 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;sno(s)RNA-containing ribonucleoprotein complex#GO:0005732 HUMAN|HGNC=9277|UniProtKB=O15297 O15297 PPM1D PTHR47992:SF253 PROTEIN PHOSPHATASE PROTEIN PHOSPHATASE 1D protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787;protein binding#GO:0005515;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;kinase binding#GO:0019900;binding#GO:0005488;mitogen-activated protein kinase binding#GO:0051019;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;chromatin remodeling#GO:0006338;regulation of cell communication#GO:0010646;negative regulation of metabolic process#GO:0009892;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;chromatin organization#GO:0006325;regulation of signal transduction#GO:0009966;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of gene expression, epigenetic#GO:0045814;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583 protein phosphatase#PC00195;protein modifying enzyme#PC00260 p53 pathway feedback loops 2#P04398>WIP-1#G04708;p53 pathway#P00059>WIP-1#G04693;p53 pathway feedback loops 2#P04398>WIP-1#P04650 HUMAN|HGNC=687|UniProtKB=O95661 O95661 DIRAS3 PTHR24070:SF269 RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY GTP-BINDING PROTEIN DI-RAS3 hydrolase activity, acting on acid anhydrides#GO:0016817;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;signaling#GO:0023052;intracellular signaling cassette#GO:0141124;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 small GTPase#PC00208 HUMAN|HGNC=19686|UniProtKB=Q99611 Q99611 SEPHS2 PTHR10256:SF1 SELENIDE, WATER DIKINASE SELENIDE, WATER DIKINASE 2 catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 small molecule biosynthetic process#GO:0044283;amino acid biosynthetic process#GO:0008652;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;proteinogenic amino acid biosynthetic process#GO:0170038;cellular process#GO:0009987;carboxylic acid biosynthetic process#GO:0046394;carboxylic acid metabolic process#GO:0019752;modified amino acid metabolic process#GO:0006575;primary metabolic process#GO:0044238;amino acid metabolic process#GO:0006520;biosynthetic process#GO:0009058;proteinogenic amino acid metabolic process#GO:0170039;small molecule metabolic process#GO:0044281 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 metabolite interconversion enzyme#PC00262;transferase#PC00220 HUMAN|HGNC=29787|UniProtKB=Q969P6 Q969P6 TOP1MT PTHR10290:SF1 DNA TOPOISOMERASE I DNA TOPOISOMERASE I, MITOCHONDRIAL macromolecular conformation isomerase activity#GO:0120543;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;isomerase activity#GO:0016853;catalytic activity, acting on DNA#GO:0140097 cell cycle#GO:0007049;organelle organization#GO:0006996;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;DNA replication#GO:0006260;cell cycle process#GO:0022402;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;chromosome segregation#GO:0007059;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;chromosome organization#GO:0051276 organelle#GO:0043226;nucleoid#GO:0009295;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;mitochondrion#GO:0005739;mitochondrial nucleoid#GO:0042645;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membraneless organelle#GO:0043228 DNA topoisomerase#PC00017;DNA metabolism protein#PC00009 DNA replication#P00017>DNA Topisomerase#P00536 HUMAN|HGNC=15296|UniProtKB=Q8NGG2 Q8NGG2 OR5T2 PTHR48018:SF189 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5T2 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;sensory perception#GO:0007600;nervous system process#GO:0050877;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;sensory perception of smell#GO:0007608 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=14193|UniProtKB=Q9NZN5 Q9NZN5 ARHGEF12 PTHR45872:SF3 RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 12 guanyl-nucleotide exchange factor activity#GO:0005085;binding#GO:0005488;signaling receptor binding#GO:0005102;enzyme regulator activity#GO:0030234;protein binding#GO:0005515;G protein-coupled receptor binding#GO:0001664;molecular function regulator activity#GO:0098772;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=9864|UniProtKB=P10276 P10276 RARA PTHR24082:SF115 NUCLEAR HORMONE RECEPTOR RETINOIC ACID RECEPTOR ALPHA sequence-specific double-stranded DNA binding#GO:1990837;cis-regulatory region sequence-specific DNA binding#GO:0000987;molecular transducer activity#GO:0060089;nuclear receptor activity#GO:0004879;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulator activity#GO:0140110 hormone-mediated signaling pathway#GO:0009755;negative regulation of DNA-templated transcription#GO:0045892;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;cellular response to chemical stimulus#GO:0070887;cellular response to hormone stimulus#GO:0032870;cell differentiation#GO:0030154;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;signaling#GO:0023052;negative regulation of biological process#GO:0048519;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;positive regulation of transcription by RNA polymerase II#GO:0045944;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;response to chemical#GO:0042221;positive regulation of macromolecule metabolic process#GO:0010604;response to hormone#GO:0009725;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;cell communication#GO:0007154;regulation of RNA metabolic process#GO:0051252;intracellular signal transduction#GO:0035556;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;intracellular receptor signaling pathway#GO:0030522;cellular response to stimulus#GO:0051716;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;positive regulation of DNA-templated transcription#GO:0045893;nuclear receptor-mediated signaling pathway#GO:0141193;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522 organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 C4 zinc finger nuclear receptor#PC00169 Vitamin D metabolism and pathway#P04396>RXR#P04602 HUMAN|HGNC=25629|UniProtKB=Q9NUU6 Q9NUU6 OTULINL PTHR33662:SF1 OTU DEUBIQUITINASE WITH LINEAR LINKAGE-SPECIFICITY A-RELATED INACTIVE UBIQUITIN THIOESTERASE OTULINL cytoplasm#GO:0005737;endomembrane system#GO:0012505;cytoplasmic side of endoplasmic reticulum membrane#GO:0098554;membrane#GO:0016020;organelle membrane#GO:0031090;endoplasmic reticulum#GO:0005783;cytoplasmic side of membrane#GO:0098562;endoplasmic reticulum membrane#GO:0005789;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;side of membrane#GO:0098552;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229 HUMAN|HGNC=10549|UniProtKB=Q9UBB4 Q9UBB4 ATXN10 PTHR13255:SF1 ATAXIN-10 ATAXIN-10 cellular component biogenesis#GO:0044085;neuron projection development#GO:0031175;organelle organization#GO:0006996;cellular process#GO:0009987;cell projection assembly#GO:0030031;multicellular organismal process#GO:0032501;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;nervous system development#GO:0007399;plasma membrane bounded cell projection assembly#GO:0120031;neuron differentiation#GO:0030182;developmental process#GO:0032502;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;neurogenesis#GO:0022008;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell development#GO:0048468;animal gross anatomical part developmental process#GO:0160108;organelle assembly#GO:0070925;generation of neurons#GO:0048699;anatomical structure development#GO:0048856;cilium organization#GO:0044782;neuron development#GO:0048666;system development#GO:0048731 intracellular anatomical structure#GO:0005622;dendritic tree#GO:0097447;dendrite#GO:0030425;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;somatodendritic compartment#GO:0036477;cellular anatomical structure#GO:0110165;neuron projection#GO:0043005;cytosol#GO:0005829 HUMAN|HGNC=26677|UniProtKB=Q8NA19 Q8NA19 L3MBTL4 PTHR12247:SF78 POLYCOMB GROUP PROTEIN LETHAL(3)MALIGNANT BRAIN TUMOR-LIKE PROTEIN 4 chromatin binding#GO:0003682;histone binding#GO:0042393;binding#GO:0005488;protein binding#GO:0005515 negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=9507|UniProtKB=A5PKW4 A5PKW4 PSD PTHR10663:SF334 GUANYL-NUCLEOTIDE EXCHANGE FACTOR PH AND SEC7 DOMAIN-CONTAINING PROTEIN 1 ruffle membrane#GO:0032587;leading edge membrane#GO:0031256;cell projection membrane#GO:0031253;ruffle#GO:0001726;cell leading edge#GO:0031252;membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025 guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=214|UniProtKB=Q9H2U9 Q9H2U9 ADAM7 PTHR11905:SF21 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 7 metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;primary metabolic process#GO:0044238;metabolic process#GO:0008152;proteolysis#GO:0006508 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 metalloprotease#PC00153;protease#PC00190 HUMAN|HGNC=4046|UniProtKB=Q9H461 Q9H461 FZD8 PTHR11309:SF90 FRIZZLED FRIZZLED-8 molecular transducer activity#GO:0060089;protein binding#GO:0005515;Wnt-protein binding#GO:0017147;signaling receptor activity#GO:0038023;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888 Wnt signaling pathway#GO:0016055;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;non-canonical Wnt signaling pathway#GO:0035567;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;canonical Wnt signaling pathway#GO:0060070;cell surface receptor signaling pathway#GO:0007166 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 Alzheimer disease-presenilin pathway#P00004>Frizzled#P00119;Wnt signaling pathway#P00057>Frizzled#P01428;Cadherin signaling pathway#P00012>Frizzled#P00475;Angiogenesis#P00005>Fzd#P00189 HUMAN|HGNC=29081|UniProtKB=Q4V321 Q4V321 GAGE13 PTHR14047:SF30 P ANTIGEN FAMILY MEMBER 5-RELATED G ANTIGEN 1-RELATED HUMAN|HGNC=11980|UniProtKB=Q14106 Q14106 TOB2 PTHR17537:SF3 TRANSDUCER OF ERBB2 TOB PROTEIN TOB2 transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=32931|UniProtKB=Q6B9Z1 Q6B9Z1 IGFL4 PTHR34827:SF1 INSULIN GROWTH FACTOR-LIKE FAMILY MEMBER 3-RELATED INSULIN GROWTH FACTOR-LIKE FAMILY MEMBER 4 signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207;growth factor#PC00112 HUMAN|HGNC=4704|UniProtKB=P04921 P04921 GYPC PTHR47614:SF2 GLYCOPHORIN-C GLYCOPHORIN-C intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell cortex#GO:0005938;cell periphery#GO:0071944;membrane#GO:0016020;cortical cytoskeleton#GO:0030863 HUMAN|HGNC=2731|UniProtKB=Q16832 Q16832 DDR2 PTHR24416:SF295 TYROSINE-PROTEIN KINASE RECEPTOR DISCOIDIN DOMAIN-CONTAINING RECEPTOR 2 protein-containing complex binding#GO:0044877;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488;collagen binding#GO:0005518;signaling receptor activity#GO:0038023;kinase activity#GO:0016301;transferase activity#GO:0016740;transmembrane receptor protein tyrosine kinase activity#GO:0004714;molecular transducer activity#GO:0060089;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713 biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of response to stimulus#GO:0048584;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166;positive regulation of intracellular signal transduction#GO:1902533;regulation of cell communication#GO:0010646;signaling#GO:0023052;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051897;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051896;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of signaling#GO:0023056;cell communication#GO:0007154;regulation of signaling#GO:0023051;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of intracellular signal transduction#GO:1902531 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;signaling receptor complex#GO:0043235;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=21767|UniProtKB=P0CG23 P0CG23 ZNF853 PTHR23226:SF192 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER PROTEIN 853 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=12147|UniProtKB=A0A0B4J237 A0A0B4J237 TRAV8-2 PTHR19367:SF21 T-CELL RECEPTOR ALPHA CHAIN V REGION T CELL RECEPTOR ALPHA VARIABLE 8-2 immune system process#GO:0002376;immune response#GO:0006955;response to stimulus#GO:0050896;adaptive immune response#GO:0002250 protein-containing complex#GO:0032991 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=24084|UniProtKB=Q2M3G4 Q2M3G4 SHROOM1 PTHR15012:SF39 APICAL PROTEIN/SHROOM-RELATED PROTEIN SHROOM1 protein-containing complex binding#GO:0044877;protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;actin filament binding#GO:0051015;actin binding#GO:0003779;binding#GO:0005488 supramolecular fiber organization#GO:0097435;anatomical structure development#GO:0048856;actin filament-based process#GO:0030029;cell morphogenesis#GO:0000902;actin cytoskeleton organization#GO:0030036;anatomical structure morphogenesis#GO:0009653;actin filament bundle assembly#GO:0051017;actin filament bundle organization#GO:0061572;cellular component organization#GO:0016043;actin filament organization#GO:0007015;cellular component organization or biogenesis#GO:0071840;developmental process#GO:0032502;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996 membraneless organelle#GO:0043228;cell junction#GO:0030054;adherens junction#GO:0005912;cytoskeleton#GO:0005856;apical junction complex#GO:0043296;apical part of cell#GO:0045177;plasma membrane region#GO:0098590;cortical actin cytoskeleton#GO:0030864;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;membrane#GO:0016020;cell-cell junction#GO:0005911;cell periphery#GO:0071944;anchoring junction#GO:0070161;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cortical cytoskeleton#GO:0030863;apical plasma membrane#GO:0016324;actin cytoskeleton#GO:0015629;cell cortex#GO:0005938 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=18196|UniProtKB=Q9BT81 Q9BT81 SOX7 PTHR10270:SF210 SOX TRANSCRIPTION FACTOR TRANSCRIPTION FACTOR SOX-7 sequence-specific DNA binding#GO:0043565;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription activator activity#GO:0001216;transcription regulator activity#GO:0140110;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676 regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;positive regulation of transcription by RNA polymerase II#GO:0045944;developmental process#GO:0032502;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;HMG box transcription factor#PC00024;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=26532|UniProtKB=Q96M86 Q96M86 DNHD1 PTHR10676:SF359 DYNEIN HEAVY CHAIN FAMILY PROTEIN DYNEIN HEAVY CHAIN DOMAIN-CONTAINING PROTEIN 1 binding#GO:0005488;polypeptide conformation or assembly isomerase activity#GO:0120544;ATP-dependent activity#GO:0140657;protein binding#GO:0005515;microtubule motor activity#GO:0003777;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543;cytoskeletal motor activity#GO:0003774;isomerase activity#GO:0016853 cilium movement involved in cell motility#GO:0060294;cellular process#GO:0009987;microtubule-based movement#GO:0007018;cell motility#GO:0048870;cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;cilium-dependent cell motility#GO:0060285;microtubule-based process#GO:0007017 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cilium#GO:0005929;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;9+2 motile cilium#GO:0097729;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;motile cilium#GO:0031514;organelle#GO:0043226;dynein complex#GO:0030286;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;microtubule cytoskeleton#GO:0015630 microtubule or microtubule-binding cytoskeletal protein#PC00157;microtubule binding motor protein#PC00156 HUMAN|HGNC=790|UniProtKB=Q9Y2D1 Q9Y2D1 ATF5 PTHR13044:SF3 ACTIVATING TRANSCRIPTION FACTOR ATF 4/5 CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-5 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription activator activity#GO:0001216;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=26574|UniProtKB=Q96LX7 Q96LX7 CCDC17 PTHR33820:SF4 COILED-COIL DOMAIN-CONTAINING PROTEIN 17 COILED-COIL DOMAIN-CONTAINING PROTEIN 17 HUMAN|HGNC=24426|UniProtKB=Q8N1L4 Q8N1L4 CYP4Z2P PTHR24291:SF63 CYTOCHROME P450 FAMILY 4 CYTOCHROME P450 4X1-RELATED oxygenase#PC00177;metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HUMAN|HGNC=3501|UniProtKB=O60447 O60447 EVI5 PTHR22957:SF679 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN ECOTROPIC VIRAL INTEGRATION SITE 5 PROTEIN HOMOLOG enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047 localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;endosomal transport#GO:0016197;intracellular transport#GO:0046907;transport#GO:0006810;vesicle-mediated transport#GO:0016192;cytosolic transport#GO:0016482;retrograde transport, endosome to Golgi#GO:0042147;establishment of localization in cell#GO:0051649;cellular process#GO:0009987 protein-binding activity modulator#PC00095;G-protein modulator#PC00022;GTPase-activating protein#PC00257 HUMAN|HGNC=565|UniProtKB=P53680 P53680 AP2S1 PTHR11753:SF6 ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY AP-2 COMPLEX SUBUNIT SIGMA localization#GO:0051179;vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;transport#GO:0006810;cellular process#GO:0009987 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229 vesicle coat protein#PC00235;membrane traffic protein#PC00150 HUMAN|HGNC=14942|UniProtKB=Q86XI6 Q86XI6 PPP1R3B PTHR12307:SF13 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 3B enzyme binding#GO:0019899;phosphatase binding#GO:0019902;binding#GO:0005488;polysaccharide binding#GO:0030247;protein phosphatase binding#GO:0019903;carbohydrate binding#GO:0030246;protein binding#GO:0005515 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of polysaccharide metabolic process#GO:0032881;biological regulation#GO:0065007;regulation of carbohydrate biosynthetic process#GO:0043255;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of glycogen biosynthetic process#GO:0005979;regulation of carbohydrate metabolic process#GO:0006109;regulation of polysaccharide biosynthetic process#GO:0032885;regulation of biosynthetic process#GO:0009889 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;protein serine/threonine phosphatase complex#GO:0008287 phosphatase modulator#PC00184;protein-binding activity modulator#PC00095 HUMAN|HGNC=2715|UniProtKB=O94760 O94760 DDAH1 PTHR12737:SF17 DIMETHYLARGININE DIMETHYLAMINOHYDROLASE N(G),N(G)-DIMETHYLARGININE DIMETHYLAMINOHYDROLASE 1 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity#GO:0016787;catalytic activity#GO:0003824 regulation of metabolic process#GO:0019222;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;amino acid metabolic process#GO:0006520;arginine metabolic process#GO:0006525;biological regulation#GO:0065007;metabolic process#GO:0008152;regulation of biosynthetic process#GO:0009889;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;small molecule metabolic process#GO:0044281;oxoacid metabolic process#GO:0043436;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893 hydrolase#PC00121 HUMAN|HGNC=15852|UniProtKB=Q8N6T3 Q8N6T3 ARFGAP1 PTHR46395:SF1 ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1 ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1 molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;enzyme activator activity#GO:0008047 regulation of biological process#GO:0050789;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cell communication#GO:0010646;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of endocytosis#GO:0030100;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;regulation of small GTPase mediated signal transduction#GO:0051056;regulation of localization#GO:0032879;regulation of transport#GO:0051049 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;intracellular organelle#GO:0043229 GTPase-activating protein#PC00257;G-protein modulator#PC00022 Integrin signalling pathway#P00034>ASAP1#P00909 HUMAN|HGNC=20962|UniProtKB=Q9NT62 Q9NT62 ATG3 PTHR12866:SF2 UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3 UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3 catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein conjugating enzyme activity#GO:0061650;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787 polysaccharide catabolic process#GO:0000272;glycogen metabolic process#GO:0005977;cellular component organization#GO:0016043;glucan metabolic process#GO:0044042;primary metabolic process#GO:0044238;carbohydrate metabolic process#GO:0005975;glucan catabolic process#GO:0009251;catabolic process#GO:0009056;polysaccharide metabolic process#GO:0005976;energy reserve metabolic process#GO:0006112;organelle assembly#GO:0070925;vacuole organization#GO:0007033;process utilizing autophagic mechanism#GO:0061919;carbohydrate catabolic process#GO:0016052;autophagy#GO:0006914;autophagosome organization#GO:1905037;cellular process#GO:0009987;glycogen catabolic process#GO:0005980;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;macroautophagy#GO:0016236;cellular component assembly#GO:0022607;generation of precursor metabolites and energy#GO:0006091;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;autophagy of mitochondrion#GO:0000422;autophagosome assembly#GO:0000045;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;energy derivation by oxidation of organic compounds#GO:0015980 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829;phagophore assembly site#GO:0000407 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=29472|UniProtKB=A4D1U4 A4D1U4 DENND11 PTHR31017:SF2 LATE SECRETORY PATHWAY PROTEIN AVL9-RELATED DENN DOMAIN-CONTAINING PROTEIN 11 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=21316|UniProtKB=Q6UB99 Q6UB99 ANKRD11 PTHR24145:SF3 ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 11 ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 11 anatomical structure development#GO:0048856;developmental process#GO:0032502;anatomical structure morphogenesis#GO:0009653 HUMAN|HGNC=1041|UniProtKB=Q13515 Q13515 BFSP2 PTHR23239:SF32 INTERMEDIATE FILAMENT PHAKININ cellular component organization or biogenesis#GO:0071840;supramolecular fiber organization#GO:0097435;intermediate filament-based process#GO:0045103;intermediate filament organization#GO:0045109;intermediate filament cytoskeleton organization#GO:0045104;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987 intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intermediate filament#GO:0005882;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228 intermediate filament#PC00129 HUMAN|HGNC=11938|UniProtKB=P32971 P32971 TNFSF8 PTHR32163:SF1 TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 8 TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 8 anatomical structure development#GO:0048856;lymphocyte differentiation#GO:0030098;cell activation#GO:0001775;immune system process#GO:0002376;cell development#GO:0048468;cell differentiation#GO:0030154;mononuclear cell differentiation#GO:1903131;leukocyte activation#GO:0045321;leukocyte differentiation#GO:0002521;T cell activation#GO:0042110;cellular developmental process#GO:0048869;developmental process#GO:0032502;hemopoiesis#GO:0030097;T cell differentiation#GO:0030217;lymphocyte activation#GO:0046649;multicellular organismal process#GO:0032501;cellular process#GO:0009987 intercellular signal molecule#PC00207 HUMAN|HGNC=16389|UniProtKB=Q96EW2 Q96EW2 HSPBAP1 PTHR12461:SF43 HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED HSPB1-ASSOCIATED PROTEIN 1 catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;oxidoreductase activity#GO:0016491;dioxygenase activity#GO:0051213 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260 HUMAN|HGNC=4179|UniProtKB=O75323 O75323 NIPSNAP2 PTHR21017:SF14 NIPSNAP-RELATED PROTEIN NIPSNAP HOMOLOG 2 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 mitophagy#GO:0000423;process utilizing autophagic mechanism#GO:0061919;metabolic process#GO:0008152;autophagy of mitochondrion#GO:0000422;catabolic process#GO:0009056;macroautophagy#GO:0016236;autophagy#GO:0006914;cellular process#GO:0009987 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=13110|UniProtKB=P15621 P15621 ZNF44 PTHR24379:SF98 KRAB AND ZINC FINGER DOMAIN-CONTAINING ZINC FINGER PROTEIN 44 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HUMAN|HGNC=4928|UniProtKB=P10072 P10072 ZNF875 PTHR24381:SF395 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 875 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=13083|UniProtKB=Q9ULJ3 Q9ULJ3 ZBTB21 PTHR24394:SF15 ZINC FINGER PROTEIN ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 21 DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HUMAN|HGNC=1557|UniProtKB=O95931 O95931 CBX7 PTHR47277:SF1 CHROMOBOX PROTEIN HOMOLOG 7 CHROMOBOX PROTEIN HOMOLOG 7 regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;PcG protein complex#GO:0031519;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=19375|UniProtKB=Q9BV35 Q9BV35 SLC25A23 PTHR24089:SF196 SOLUTE CARRIER FAMILY 25 MITOCHONDRIAL ADENYL NUCLEOTIDE ANTIPORTER SLC25A23 active transmembrane transporter activity#GO:0022804;purine nucleotide transmembrane transporter activity#GO:0015216;antiporter activity#GO:0015297;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;organophosphate ester transmembrane transporter activity#GO:0015605;nucleobase-containing compound transmembrane transporter activity#GO:0015932;carbohydrate derivative transmembrane transporter activity#GO:1901505;phosphate transmembrane transporter activity#GO:0005315 monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;carbohydrate derivative transport#GO:1901264;calcium ion transmembrane transport#GO:0070588;metal ion transport#GO:0030001;nucleobase-containing compound transport#GO:0015931;organophosphate ester transport#GO:0015748;transport#GO:0006810;calcium ion transport#GO:0006816;establishment of localization#GO:0051234;cellular process#GO:0009987;nitrogen compound transport#GO:0071705;mitochondrial calcium ion transmembrane transport#GO:0006851;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 mitochondrial carrier protein#PC00158;secondary carrier transporter#PC00258 HUMAN|HGNC=10943|UniProtKB=Q15758 Q15758 SLC1A5 PTHR11958:SF19 SODIUM/DICARBOXYLATE SYMPORTER-RELATED NEUTRAL AMINO ACID TRANSPORTER B(0) transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;amino acid transmembrane transporter activity#GO:0015171;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;symporter activity#GO:0015293;monoatomic cation transmembrane transporter activity#GO:0008324;sodium:dicarboxylate symporter activity#GO:0017153;transmembrane transporter activity#GO:0022857;neutral L-amino acid transmembrane transporter activity#GO:0015175;acidic amino acid transmembrane transporter activity#GO:0015172;L-amino acid transmembrane transporter activity#GO:0015179;sodium ion transmembrane transporter activity#GO:0015081;active transmembrane transporter activity#GO:0022804;L-glutamate transmembrane transporter activity#GO:0005313;dicarboxylic acid transmembrane transporter activity#GO:0005310;solute:monoatomic cation symporter activity#GO:0015294;carboxylic acid transmembrane transporter activity#GO:0046943;C4-dicarboxylate transmembrane transporter activity#GO:0015556;amino acid:sodium symporter activity#GO:0005283;solute:sodium symporter activity#GO:0015370 dicarboxylic acid transport#GO:0006835;L-glutamate transmembrane transport#GO:0015813;nitrogen compound transport#GO:0071705;L-amino acid transport#GO:0015807;aspartate transmembrane transport#GO:0015810;cellular process#GO:0009987;establishment of localization#GO:0051234;import into cell#GO:0098657;organic acid transport#GO:0015849;acidic amino acid transport#GO:0015800;amino acid transport#GO:0006865;C4-dicarboxylate transport#GO:0015740;transport#GO:0006810;carboxylic acid transport#GO:0046942;import across plasma membrane#GO:0098739;carboxylic acid transmembrane transport#GO:1905039;L-alpha-amino acid transmembrane transport#GO:1902475;amino acid transmembrane transport#GO:0003333;transmembrane transport#GO:0055085;localization#GO:0051179;L-glutamate import#GO:0051938 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 primary active transporter#PC00068 HUMAN|HGNC=25367|UniProtKB=Q9H0W5 Q9H0W5 CCDC8 PTHR47741:SF1 COILED COIL DOMAIN-CONTAINING PROTEIN 8, CCDC8 COILED-COIL DOMAIN-CONTAINING PROTEIN 8 regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;regulation of cell cycle#GO:0051726;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;microtubule cytoskeleton organization#GO:0000226;cellular process#GO:0009987;regulation of mitotic cell cycle#GO:0007346;organelle organization#GO:0006996;regulation of nuclear division#GO:0051783;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;regulation of cell cycle process#GO:0010564;microtubule-based process#GO:0007017;regulation of mitotic nuclear division#GO:0007088;cellular component organization or biogenesis#GO:0071840 protein-containing complex#GO:0032991 HUMAN|HGNC=2234|UniProtKB=O14579 O14579 COPE PTHR10805:SF0 COATOMER SUBUNIT EPSILON COATOMER SUBUNIT EPSILON establishment of localization#GO:0051234;vesicle-mediated transport#GO:0016192;localization#GO:0051179;Golgi vesicle transport#GO:0048193;cellular process#GO:0009987;transport#GO:0006810;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890 coated vesicle membrane#GO:0030662;Golgi-associated vesicle membrane#GO:0030660;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;COPI vesicle coat#GO:0030126;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;membrane-bounded organelle#GO:0043227;coated vesicle#GO:0030135;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;coated membrane#GO:0048475;membrane coat#GO:0030117;intracellular organelle#GO:0043229;vesicle coat#GO:0030120;cytoplasm#GO:0005737;COPI-coated vesicle#GO:0030137;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;vesicle membrane#GO:0012506;membrane#GO:0016020;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;Golgi-associated vesicle#GO:0005798;Golgi apparatus#GO:0005794 vesicle coat protein#PC00235 HUMAN|HGNC=2237|UniProtKB=Q9UBF2 Q9UBF2 COPG2 PTHR10261:SF4 COATOMER SUBUNIT GAMMA COATOMER SUBUNIT GAMMA-2 transport#GO:0006810;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;localization#GO:0051179 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;coated vesicle#GO:0030135;cytoplasmic vesicle#GO:0031410;coated membrane#GO:0048475;membrane coat#GO:0030117;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;coated vesicle membrane#GO:0030662;Golgi-associated vesicle membrane#GO:0030660;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;COPI vesicle coat#GO:0030126;cellular anatomical structure#GO:0110165;endoplasmic reticulum#GO:0005783;Golgi membrane#GO:0000139;Golgi-associated vesicle#GO:0005798;Golgi apparatus#GO:0005794;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;vesicle membrane#GO:0012506;membrane#GO:0016020;vesicle coat#GO:0030120;cytoplasm#GO:0005737;COPI-coated vesicle#GO:0030137;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;endomembrane system#GO:0012505 vesicle coat protein#PC00235 HUMAN|HGNC=24583|UniProtKB=Q7L591 Q7L591 DOK3 PTHR21258:SF42 DOCKING PROTEIN RELATED DOCKING PROTEIN 3 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;Ras protein signal transduction#GO:0007265;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789 scaffold/adaptor protein#PC00226 Angiogenesis#P00005>Dok-R#P00180 HUMAN|HGNC=4525|UniProtKB=Q9Y5X5 Q9Y5X5 NPFFR2 PTHR24241:SF132 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR NEUROPEPTIDE FF RECEPTOR 2 signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;cellular process#GO:0009987;response to hormone#GO:0009725;biological regulation#GO:0065007;response to chemical#GO:0042221;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to endogenous stimulus#GO:0009719;neuropeptide signaling pathway#GO:0007218;signaling#GO:0023052;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cellular response to hormone stimulus#GO:0032870 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=32389|UniProtKB=Q9BUT1 Q9BUT1 BDH2 PTHR43477:SF4 DIHYDROANTICAPSIN 7-DEHYDROGENASE DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 6 oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 siderophore metabolic process#GO:0009237;secondary metabolite biosynthetic process#GO:0044550;metabolic process#GO:0008152;peptide metabolic process#GO:0006518;secondary metabolic process#GO:0019748;cellular process#GO:0009987;siderophore biosynthetic process#GO:0019290;biosynthetic process#GO:0009058 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 oxidoreductase#PC00176;dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=21479|UniProtKB=Q8N8Z6 Q8N8Z6 DCBLD1 PTHR46806:SF1 F5/8 TYPE C DOMAIN-CONTAINING PROTEIN DISCOIDIN, CUB AND LCCL DOMAIN-CONTAINING PROTEIN 1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HUMAN|HGNC=26900|UniProtKB=Q2M329 Q2M329 CFAP184 PTHR15654:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 113-RELATED CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 184 organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031;cilium organization#GO:0044782;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;plasma membrane bounded cell projection organization#GO:0120036;cell projection organization#GO:0030030;cellular component assembly#GO:0022607 cilium#GO:0005929;intracellular organelle#GO:0043229;axoneme#GO:0005930;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;ciliary basal body#GO:0036064;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;ciliary plasm#GO:0097014;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737 HUMAN|HGNC=12998|UniProtKB=O43670 O43670 ZNF207 PTHR23215:SF6 ZINC FINGER PROTEIN 207 BUB3-INTERACTING AND GLEBS MOTIF-CONTAINING PROTEIN ZNF207 microtubule binding#GO:0008017;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;protein binding#GO:0005515 mitotic cell cycle#GO:0000278;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;mitotic cell cycle checkpoint signaling#GO:0007093;negative regulation of cellular component organization#GO:0051129;microtubule cytoskeleton organization involved in mitosis#GO:1902850;intracellular signal transduction#GO:0035556;localization#GO:0051179;cell communication#GO:0007154;microtubule cytoskeleton organization#GO:0000226;organelle fission#GO:0048285;negative regulation of chromosome organization#GO:2001251;organelle assembly#GO:0070925;organelle localization#GO:0051640;negative regulation of nuclear division#GO:0051784;regulation of nuclear division#GO:0051783;mitotic spindle assembly#GO:0090307;regulation of mitotic cell cycle#GO:0007346;mitotic sister chromatid segregation#GO:0000070;regulation of mitotic nuclear division#GO:0007088;spindle organization#GO:0007051;regulation of mitotic sister chromatid separation#GO:0010965;negative regulation of cell cycle process#GO:0010948;regulation of chromosome organization#GO:0033044;signaling#GO:0023052;regulation of sister chromatid segregation#GO:0033045;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;negative regulation of mitotic cell cycle#GO:0045930;regulation of mitotic cell cycle phase transition#GO:1901990;negative regulation of mitotic sister chromatid separation#GO:2000816;cytoskeleton organization#GO:0007010;regulation of cell cycle process#GO:0010564;chromosome localization#GO:0050000;cell cycle checkpoint signaling#GO:0000075;cellular component assembly#GO:0022607;mitotic spindle assembly checkpoint signaling#GO:0007094;spindle assembly#GO:0051225;attachment of spindle microtubules to kinetochore#GO:0008608;microtubule-based process#GO:0007017;negative regulation of cell cycle#GO:0045786;regulation of chromosome segregation#GO:0051983;chromosome segregation#GO:0007059;metaphase chromosome alignment#GO:0051310;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;negative regulation of mitotic metaphase/anaphase transition#GO:0045841;regulation of cell cycle phase transition#GO:1901987;cell cycle#GO:0007049;negative regulation of organelle organization#GO:0010639;regulation of mitotic sister chromatid segregation#GO:0033047;biological regulation#GO:0065007;regulation of mitotic metaphase/anaphase transition#GO:0030071;negative regulation of chromosome separation#GO:1905819;mitotic cell cycle process#GO:1903047;chromosome organization#GO:0051276;negative regulation of cellular process#GO:0048523;regulation of cell cycle#GO:0051726;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;mitotic spindle organization#GO:0007052;negative regulation of mitotic nuclear division#GO:0045839;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;mitotic nuclear division#GO:0140014;cell cycle process#GO:0022402;negative regulation of biological process#GO:0048519;sister chromatid segregation#GO:0000819;negative regulation of cell cycle phase transition#GO:1901988;nuclear chromosome segregation#GO:0098813;nuclear division#GO:0000280;regulation of chromosome separation#GO:1905818;negative regulation of mitotic cell cycle phase transition#GO:1901991;signal transduction#GO:0007165;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;negative regulation of sister chromatid segregation#GO:0033046;cellular component organization or biogenesis#GO:0071840;negative regulation of mitotic sister chromatid segregation#GO:0033048;negative regulation of metaphase/anaphase transition of cell cycle#GO:1902100;negative regulation of chromosome segregation#GO:0051985 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;kinetochore#GO:0000776;chromosome#GO:0005694;intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membraneless organelle#GO:0043232;supramolecular complex#GO:0099080;nucleus#GO:0005634;condensed chromosome, centromeric region#GO:0000779;membraneless organelle#GO:0043228;chromosome, centromeric region#GO:0000775;condensed chromosome#GO:0000793;cytoskeleton#GO:0005856 DNA metabolism protein#PC00009 HUMAN|HGNC=6512|UniProtKB=Q9P2J5 Q9P2J5 LARS1 PTHR45794:SF1 LEUCYL-TRNA SYNTHETASE LEUCINE--TRNA LIGASE, CYTOPLASMIC catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;ligase activity#GO:0016874 amino acid activation#GO:0043038;macromolecule metabolic process#GO:0043170;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;amino acid metabolic process#GO:0006520;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;tRNA aminoacylation for protein translation#GO:0006418;tRNA aminoacylation#GO:0043039;RNA metabolic process#GO:0016070;protein metabolic process#GO:0019538;translation#GO:0006412;protein biosynthetic process#GO:0160307;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 HUMAN|HGNC=13805|UniProtKB=Q9H2A3 Q9H2A3 NEUROG2 PTHR19290:SF171 BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED NEUROGENIN-2 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676 positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;axon development#GO:0061564;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;plasma membrane bounded cell projection organization#GO:0120036;regulation of nucleobase-containing compound metabolic process#GO:0019219;brain development#GO:0007420;multicellular organismal process#GO:0032501;positive regulation of DNA-templated transcription#GO:0045893;developmental process#GO:0032502;sensory organ development#GO:0007423;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;neuron projection development#GO:0031175;head development#GO:0060322;nervous system development#GO:0007399;positive regulation of macromolecule metabolic process#GO:0010604;neuron differentiation#GO:0030182;positive regulation of transcription by RNA polymerase II#GO:0045944;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;animal organ development#GO:0048513;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;cell development#GO:0048468;regulation of transcription by RNA polymerase II#GO:0006357;cell projection organization#GO:0030030;cell differentiation#GO:0030154;central nervous system development#GO:0007417;forebrain development#GO:0030900;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;neuron development#GO:0048666;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=12729|UniProtKB=P23381 P23381 WARS1 PTHR10055:SF1 TRYPTOPHANYL-TRNA SYNTHETASE TRYPTOPHAN--TRNA LIGASE, CYTOPLASMIC ligase activity#GO:0016874;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098 RNA metabolic process#GO:0016070;protein metabolic process#GO:0019538;translation#GO:0006412;protein biosynthetic process#GO:0160307;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;amino acid activation#GO:0043038;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;gene expression#GO:0010467;tRNA aminoacylation for protein translation#GO:0006418;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;tRNA aminoacylation#GO:0043039 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 HUMAN|HGNC=29051|UniProtKB=O75071 O75071 EFCAB14 PTHR15717:SF2 PROTEIN KIAA0494 EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 14 HUMAN|HGNC=17428|UniProtKB=Q9UHV5 Q9UHV5 RAPGEFL1 PTHR23113:SF230 GUANINE NUCLEOTIDE EXCHANGE FACTOR RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR-LIKE 1 enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 signaling#GO:0023052;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;intracellular signaling cassette#GO:0141124;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;Ras protein signal transduction#GO:0007265 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=6320|UniProtKB=O15066 O15066 KIF3B PTHR24115:SF744 KINESIN-RELATED KINESIN-LIKE PROTEIN KIF3B binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP-dependent activity#GO:0140657;protein binding#GO:0005515;hydrolase activity, acting on acid anhydrides#GO:0016817;cytoskeletal protein binding#GO:0008092;cytoskeletal motor activity#GO:0003774;polypeptide conformation or assembly isomerase activity#GO:0120544;microtubule binding#GO:0008017;hydrolase activity#GO:0016787;microtubule motor activity#GO:0003777;ATP hydrolysis activity#GO:0016887;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;macromolecular conformation isomerase activity#GO:0120543;tubulin binding#GO:0015631;isomerase activity#GO:0016853;ribonucleoside triphosphate phosphatase activity#GO:0017111 organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031;microtubule-based process#GO:0007017;cilium organization#GO:0044782;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;plasma membrane bounded cell projection organization#GO:0120036;microtubule-based movement#GO:0007018;cellular component assembly#GO:0022607;cell projection organization#GO:0030030 cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;microtubule associated complex#GO:0005875;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;supramolecular complex#GO:0099080;microtubule cytoskeleton#GO:0015630;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;microtubule#GO:0005874;intracellular organelle#GO:0043229 microtubule or microtubule-binding cytoskeletal protein#PC00157;microtubule binding motor protein#PC00156 HUMAN|HGNC=28163|UniProtKB=Q9BUN5 Q9BUN5 CCDC28B PTHR13400:SF2 CHEMOKINE C-C MOTIF RECEPTOR 1 COILED-COIL DOMAIN-CONTAINING PROTEIN 28B cellular component assembly#GO:0022607;cell projection organization#GO:0030030;plasma membrane bounded cell projection organization#GO:0120036;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782;plasma membrane bounded cell projection assembly#GO:0120031;organelle assembly#GO:0070925 microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;centrosome#GO:0005813;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 transmembrane signal receptor#PC00197 HUMAN|HGNC=5343|UniProtKB=Q05084 Q05084 ICA1 PTHR10164:SF3 ISLET CELL AUTOANTIGEN 1 ISLET CELL AUTOANTIGEN 1 molecular function regulator activity#GO:0098772;molecular sensor activity#GO:0140299 regulation of transport#GO:0051049;regulation of localization#GO:0032879;cellular component organization or biogenesis#GO:0071840;regulation of secretion#GO:0051046;biological regulation#GO:0065007;membrane organization#GO:0061024;cellular process#GO:0009987;regulation of biological process#GO:0050789;cellular component organization#GO:0016043 bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;membrane#GO:0016020;secretory vesicle#GO:0099503;vesicle membrane#GO:0012506;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular vesicle#GO:0097708;secretory granule membrane#GO:0030667 HUMAN|HGNC=25741|UniProtKB=Q9BS31 Q9BS31 ZNF649 PTHR24404:SF34 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 649 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218 HUMAN|HGNC=4044|UniProtKB=O60353 O60353 FZD6 PTHR11309:SF75 FRIZZLED FRIZZLED-6 binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;protein binding#GO:0005515;Wnt-protein binding#GO:0017147;signaling receptor activity#GO:0038023 regulation of cellular process#GO:0050794;Wnt signaling pathway#GO:0016055;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;non-canonical Wnt signaling pathway#GO:0035567;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154;canonical Wnt signaling pathway#GO:0060070;cell surface receptor signaling pathway#GO:0007166 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 Cadherin signaling pathway#P00012>Frizzled#P00475;Wnt signaling pathway#P00057>Frizzled#P01428;Alzheimer disease-presenilin pathway#P00004>Frizzled#P00119 HUMAN|HGNC=29374|UniProtKB=Q76NI1 Q76NI1 KNDC1 PTHR21560:SF0 VERY KIND PROTEIN KINASE NON-CATALYTIC C-LOBE DOMAIN-CONTAINING PROTEIN 1 enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 regulation of dendrite morphogenesis#GO:0048814;regulation of neuron projection development#GO:0010975;regulation of biological process#GO:0050789;regulation of dendrite development#GO:0050773;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;biological regulation#GO:0065007;regulation of developmental process#GO:0050793;regulation of cell projection organization#GO:0031344;regulation of anatomical structure morphogenesis#GO:0022603;regulation of plasma membrane bounded cell projection organization#GO:0120035 intracellular protein-containing complex#GO:0140535;dendrite#GO:0030425;dendritic tree#GO:0097447;cellular anatomical structure#GO:0110165;guanyl-nucleotide exchange factor complex#GO:0032045;protein-containing complex#GO:0032991;plasma membrane bounded cell projection#GO:0120025;neuronal cell body#GO:0043025;cell projection#GO:0042995;somatodendritic compartment#GO:0036477;neuron projection#GO:0043005;cell body#GO:0044297 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022 HUMAN|HGNC=21335|UniProtKB=Q9Y5W8 Q9Y5W8 SNX13 PTHR22775:SF51 SORTING NEXIN SORTING NEXIN-13 binding#GO:0005488;anion binding#GO:0043168;phosphatidylinositol binding#GO:0035091;small molecule binding#GO:0036094;ion binding#GO:0043167 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular vesicle#GO:0097708;vesicle#GO:0031982;membrane-bounded organelle#GO:0043227;early endosome#GO:0005769;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768 scaffold/adaptor protein#PC00226 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>RGS-PX1#P00706 HUMAN|HGNC=18862|UniProtKB=Q9H252 Q9H252 KCNH6 PTHR10217:SF468 VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL VOLTAGE-GATED INWARDLY RECTIFYING POTASSIUM CHANNEL KCNH6 monoatomic cation channel activity#GO:0005261;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;potassium channel activity#GO:0005267;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;transporter activity#GO:0005215;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated monoatomic ion channel activity#GO:0005244;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836 transport#GO:0006810;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;biological regulation#GO:0065007 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HUMAN|HGNC=27934|UniProtKB=Q6IQ16 Q6IQ16 SPOPL PTHR24413:SF91 SPECKLE-TYPE POZ PROTEIN SPECKLE-TYPE POZ PROTEIN-LIKE ubiquitin-like protein ligase binding#GO:0044389;binding#GO:0005488;enzyme binding#GO:0019899;protein binding#GO:0005515;ubiquitin protein ligase binding#GO:0031625 regulation of biological process#GO:0050789;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;cellular process#GO:0009987;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;proteasomal protein catabolic process#GO:0010498;biological regulation#GO:0065007;regulation of proteolysis#GO:0030162;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170 nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=7596|UniProtKB=O43795 O43795 MYO1B PTHR13140:SF277 MYOSIN UNCONVENTIONAL MYOSIN-IB isomerase activity#GO:0016853;cytoskeletal motor activity#GO:0003774;macromolecular conformation isomerase activity#GO:0120543;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;polypeptide conformation or assembly isomerase activity#GO:0120544;microfilament motor activity#GO:0000146 cytoskeleton organization#GO:0007010;multicellular organismal process#GO:0032501;actin filament-based movement#GO:0030048;cellular process#GO:0009987;organelle organization#GO:0006996;actin filament organization#GO:0007015;system process#GO:0003008;cellular component organization or biogenesis#GO:0071840;import into cell#GO:0098657;establishment of localization#GO:0051234;transport#GO:0006810;sensory perception of sound#GO:0007605;actin cytoskeleton organization#GO:0030036;endocytosis#GO:0006897;cellular component organization#GO:0016043;supramolecular fiber organization#GO:0097435;localization#GO:0051179;sensory perception of mechanical stimulus#GO:0050954;sensory perception#GO:0007600;actin filament-based process#GO:0030029;nervous system process#GO:0050877 actin-based cell projection#GO:0098858;microvillus#GO:0005902;actin cytoskeleton#GO:0015629;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cluster of actin-based cell projections#GO:0098862;cell periphery#GO:0071944;brush border#GO:0005903;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;apical part of cell#GO:0045177;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228 actin binding motor protein#PC00040 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HUMAN|HGNC=2324|UniProtKB=Q10570 Q10570 CPSF1 PTHR10644:SF26 DNA REPAIR/RNA PROCESSING CPSF FAMILY CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 1 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;mRNA cleavage factor complex#GO:0005849;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;mRNA cleavage and polyadenylation specificity factor complex#GO:0005847 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HUMAN|HGNC=12744|UniProtKB=Q9NP71 Q9NP71 MLXIPL PTHR15741:SF14 BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR CARBOHYDRATE-RESPONSIVE ELEMENT-BINDING PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218 HUMAN|HGNC=30788|UniProtKB=Q9H808 Q9H808 TLE6 PTHR10814:SF2 TRANSDUCIN-LIKE ENHANCER PROTEIN TRANSDUCIN-LIKE ENHANCER PROTEIN 6 transcription regulator activity#GO:0140110;transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712 negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of canonical Wnt signaling pathway#GO:0060828;negative regulation of response to stimulus#GO:0048585;negative regulation of Wnt signaling pathway#GO:0030178;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signaling#GO:0023057;negative regulation of canonical Wnt signaling pathway#GO:0090090;regulation of signaling#GO:0023051;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 transcription cofactor#PC00217 Wnt signaling pathway#P00057>Transducin-like Enhance of Split 1-3#P01436 HUMAN|HGNC=11922|UniProtKB=P26842 P26842 CD27 PTHR47496:SF1 CD27 CD27 ANTIGEN regulation of apoptotic process#GO:0042981;negative regulation of cellular process#GO:0048523;regulation of biological process#GO:0050789;negative regulation of programmed cell death#GO:0043069;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;negative regulation of apoptotic process#GO:0043066 membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;plasma membrane#GO:0005886 HUMAN|HGNC=11515|UniProtKB=O15178 O15178 TBXT PTHR11267:SF83 T-BOX PROTEIN-RELATED T-BOX TRANSCRIPTION FACTOR T sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;mesoderm formation#GO:0001707;regulation of nucleobase-containing compound metabolic process#GO:0019219;epithelium development#GO:0060429;regionalization#GO:0003002;tissue development#GO:0009888;multicellular organismal process#GO:0032501;developmental process#GO:0032502;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;heart morphogenesis#GO:0003007;mesoderm morphogenesis#GO:0048332;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;animal organ morphogenesis#GO:0009887;pattern specification process#GO:0007389;embryo development ending in birth or egg hatching#GO:0009792;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;tissue morphogenesis#GO:0048729;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;cellular process#GO:0009987;embryo development#GO:0009790;heart development#GO:0007507;cell fate specification#GO:0001708;anterior/posterior pattern specification#GO:0009952;anatomical structure formation involved in morphogenesis#GO:0048646;embryonic morphogenesis#GO:0048598;multicellular organism development#GO:0007275;mesoderm development#GO:0007498;animal organ development#GO:0048513;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;gastrulation#GO:0007369;cell differentiation#GO:0030154;circulatory system development#GO:0072359;regulation of transcription by RNA polymerase II#GO:0006357;formation of primary germ layer#GO:0001704;animal gross anatomical part developmental process#GO:0160108;chordate embryonic development#GO:0043009;cell fate commitment#GO:0045165 intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229 Rel homology transcription factor#PC00252;immunoglobulin fold transcription factor#PC00251 Wnt signaling pathway#P00057>Wnt Target Genes#G01558 HUMAN|HGNC=5562|UniProtKB=A0A0G2JMI3 A0A0G2JMI3 IGHV1-69-2 PTHR23266:SF317 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 1-69-2 antigen binding#GO:0003823;binding#GO:0005488 immune response#GO:0006955;response to stimulus#GO:0050896;adaptive immune response#GO:0002250;immune system process#GO:0002376;immune effector process#GO:0002252;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=13815|UniProtKB=Q9HAY6 Q9HAY6 BCO1 PTHR10543:SF132 BETA-CAROTENE DIOXYGENASE BETA,BETA-CAROTENE 15,15'-DIOXYGENASE dioxygenase activity#GO:0051213;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen#GO:0016702;catalytic activity#GO:0003824 terpenoid metabolic process#GO:0006721;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;olefinic compound metabolic process#GO:0120254;diterpenoid metabolic process#GO:0016101;retinoid metabolic process#GO:0001523;isoprenoid metabolic process#GO:0006720;lipid catabolic process#GO:0016042;cellular process#GO:0009987;aldehyde metabolic process#GO:0006081;primary metabolic process#GO:0044238;catabolic process#GO:0009056 oxidoreductase#PC00176;oxygenase#PC00177 HUMAN|HGNC=26684|UniProtKB=Q8NDM7 Q8NDM7 CFAP43 PTHR14885:SF1 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 43-RELATED CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 43 plasma membrane bounded cell projection assembly#GO:0120031;flagellated sperm motility#GO:0030317;spermatogenesis#GO:0007283;developmental process#GO:0032502;cellular developmental process#GO:0048869;sperm axoneme assembly#GO:0007288;male gamete generation#GO:0048232;plasma membrane bounded cell projection organization#GO:0120036;organelle assembly#GO:0070925;sexual reproduction#GO:0019953;microtubule bundle formation#GO:0001578;spermatid development#GO:0007286;microtubule cytoskeleton organization#GO:0000226;anatomical structure development#GO:0048856;axoneme assembly#GO:0035082;multicellular organismal reproductive process#GO:0048609;developmental process involved in reproduction#GO:0003006;germ cell development#GO:0007281;cell motility#GO:0048870;microtubule-based movement#GO:0007018;reproductive process#GO:0022414;motile cilium assembly#GO:0044458;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cilium movement involved in cell motility#GO:0060294;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;spermatid differentiation#GO:0048515;cilium or flagellum-dependent cell motility#GO:0001539;cilium movement#GO:0003341;cilium-dependent cell motility#GO:0060285;sperm flagellum assembly#GO:0120316;cilium organization#GO:0044782;cellular component organization#GO:0016043;cilium assembly#GO:0060271;sperm motility#GO:0097722;cell projection organization#GO:0030030;cell differentiation#GO:0030154;gamete generation#GO:0007276;cellular process involved in reproduction in multicellular organism#GO:0022412;cell development#GO:0048468 intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;ciliary plasm#GO:0097014;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;cilium#GO:0005929;cytoskeleton#GO:0005856;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;axoneme#GO:0005930 HUMAN|HGNC=3797|UniProtKB=P53539 P53539 FOSB PTHR23351:SF3 FOS TRANSCRIPTION FACTOR-RELATED PROTEIN FOSB nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 basic leucine zipper transcription factor#PC00056 Gonadotropin-releasing hormone receptor pathway#P06664>Fosb#G06666;Gonadotropin-releasing hormone receptor pathway#P06664>Fosb#G06878;Gonadotropin-releasing hormone receptor pathway#P06664>FOS#P06709 HUMAN|HGNC=24908|UniProtKB=Q5SWL8 Q5SWL8 PRAMEF19 PTHR14224:SF76 SIMILAR TO PREFERENTIALLY EXPRESSED ANTIGEN IN MELANOMA-LIKE 3 PRAME FAMILY MEMBER 19 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;enzyme-substrate adaptor activity#GO:0140767;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cullin-RING ubiquitin ligase complex#GO:0031461;cytoplasm#GO:0005737;ubiquitin ligase complex#GO:0000151;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;transferase complex#GO:1990234;Cul2-RING ubiquitin ligase complex#GO:0031462 HUMAN|HGNC=19299|UniProtKB=Q86T03 Q86T03 PIP4P1 PTHR21014:SF2 PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 4-PHOSPHATASE TYPE 1 PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 4-PHOSPHATASE phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791 dephosphorylation#GO:0016311;lipid modification#GO:0030258;phosphatidylinositol dephosphorylation#GO:0046856;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;phosphatidylinositol metabolic process#GO:0046488;glycerophospholipid metabolic process#GO:0006650;glycerolipid metabolic process#GO:0046486;phospholipid metabolic process#GO:0006644;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;phosphate-containing compound metabolic process#GO:0006796;phospholipid dephosphorylation#GO:0046839 lytic vacuole#GO:0000323;vacuolar membrane#GO:0005774;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;late endosome membrane#GO:0031902;phagocytic vesicle#GO:0045335;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;late endosome#GO:0005770;vacuole#GO:0005773;plasma membrane#GO:0005886;cytoplasm#GO:0005737;vesicle membrane#GO:0012506;membrane#GO:0016020;lysosomal membrane#GO:0005765;cell periphery#GO:0071944;endocytic vesicle#GO:0030139;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endosome membrane#GO:0010008;endosome#GO:0005768;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;lytic vacuole membrane#GO:0098852;vesicle#GO:0031982;lysosome#GO:0005764 phosphatase#PC00181;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=28734|UniProtKB=Q8IWE4 Q8IWE4 DCUN1D3 PTHR12281:SF31 RP42 RELATED DCN1-LIKE PROTEIN 3 protein binding#GO:0005515;ubiquitin-like protein transferase activity#GO:0019787;binding#GO:0005488;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740 regulation of protein modification process#GO:0031399;regulation of post-translational protein modification#GO:1901873;positive regulation of metabolic process#GO:0009893;positive regulation of protein metabolic process#GO:0051247;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of protein modification by small protein conjugation or removal#GO:1903320;regulation of protein metabolic process#GO:0051246;regulation of primary metabolic process#GO:0080090 nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=14728|UniProtKB=Q8NGD2 Q8NGD2 OR4K2 PTHR48002:SF104 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 4K2 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=27901|UniProtKB=Q5BKU9 Q5BKU9 OXLD1 PTHR21193:SF3 OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1 OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1 oxidoreductase#PC00176 HUMAN|HGNC=14185|UniProtKB=Q5T6F2 Q5T6F2 UBAP2 PTHR16308:SF19 UBIQUITIN ASSOCIATED PROTEIN 2-LIKE/LINGERER UBIQUITIN-ASSOCIATED PROTEIN 2 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HUMAN|HGNC=1478|UniProtKB=Q9UMQ6 Q9UMQ6 CAPN11 PTHR10183:SF322 CALPAIN CALPAIN-11 cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;cysteine-type endopeptidase activity#GO:0004197;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 primary metabolic process#GO:0044238;metabolic process#GO:0008152;proteolysis#GO:0006508;cellular process#GO:0009987;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 cysteine protease#PC00081;protease#PC00190 Huntington disease#P00029>Calpain#P00788 HUMAN|HGNC=5746|UniProtKB=P01611 P01611 IGKV1D-12 PTHR23267:SF474 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN KAPPA VARIABLE 1-12-RELATED immune response#GO:0006955;immune system process#GO:0002376;response to stimulus#GO:0050896 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=12535|UniProtKB=P35503 P35503 UGT1A3 PTHR48050:SF12 STEROL 3-BETA-GLUCOSYLTRANSFERASE UDP-GLUCURONOSYLTRANSFERASE 1A3-RELATED glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194;molecular function regulator activity#GO:0098772;catalytic activity#GO:0003824;transferase activity#GO:0016740;enzyme inhibitor activity#GO:0004857;protein binding#GO:0005515;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;binding#GO:0005488;enzyme binding#GO:0019899 cellular process#GO:0009987;response to hormone#GO:0009725;steroid metabolic process#GO:0008202;cellular response to lipid#GO:0071396;response to lipid#GO:0033993;response to chemical#GO:0042221;metabolic process#GO:0008152;animal organ development#GO:0048513;cellular response to steroid hormone stimulus#GO:0071383;multicellular organism development#GO:0007275;regulation of hormone levels#GO:0010817;response to endogenous stimulus#GO:0009719;liver development#GO:0001889;cellular response to hormone stimulus#GO:0032870;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;animal gross anatomical part developmental process#GO:0160108;cellular response to chemical stimulus#GO:0070887;regulation of biological quality#GO:0065008;estrogen metabolic process#GO:0008210;pigment metabolic process#GO:0042440;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;hormone metabolic process#GO:0042445;lipid metabolic process#GO:0006629;developmental process#GO:0032502;sterol metabolic process#GO:0016125;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;response to steroid hormone#GO:0048545;system development#GO:0048731;anatomical structure development#GO:0048856 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111;transferase#PC00220 Nicotine degradation#P05914>UGT1A4#P05982 HUMAN|HGNC=17157|UniProtKB=Q6P2E9 Q6P2E9 EDC4 PTHR15598:SF5 ENHANCER OF MRNA-DECAPPING PROTEIN 4 ENHANCER OF MRNA-DECAPPING PROTEIN 4 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;molecular condensate scaffold activity#GO:0140693 negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;nucleic acid catabolic process#GO:0141188;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;nucleobase-containing compound catabolic process#GO:0034655;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;metabolic process#GO:0008152;negative regulation of cellular process#GO:0048523;macromolecule catabolic process#GO:0009057;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;negative regulation of gene expression#GO:0010629;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;RNA catabolic process#GO:0006401;RNA decapping#GO:0110154;RNA metabolic process#GO:0016070 P-body#GO:0000932;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;organelle#GO:0043226;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232 mRNA capping factor#PC00145 HUMAN|HGNC=5906|UniProtKB=A0A075B6J6 A0A075B6J6 IGLV3-22 PTHR23267:SF359 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN LAMBDA VARIABLE 3-22 response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=28440|UniProtKB=Q68CQ4 Q68CQ4 UTP25 PTHR12933:SF0 ORF PROTEIN-RELATED U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 25 HOMOLOG rRNA binding#GO:0019843;nucleic acid binding#GO:0003676;snoRNA binding#GO:0030515;binding#GO:0005488;U3 snoRNA binding#GO:0034511;RNA binding#GO:0003723 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;ribonucleoprotein complex biogenesis#GO:0022613;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;maturation of SSU-rRNA#GO:0030490;gene expression#GO:0010467;ribosomal small subunit biogenesis#GO:0042274;metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;small-subunit processome#GO:0032040;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;preribosome#GO:0030684;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228 RNA metabolism protein#PC00031 HUMAN|HGNC=4868|UniProtKB=O95714 O95714 HERC2 PTHR22870:SF398 REGULATOR OF CHROMOSOME CONDENSATION E3 UBIQUITIN-PROTEIN LIGASE HERC2 acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;protein modification process#GO:0036211;primary metabolic process#GO:0044238;cellular process#GO:0009987;protein modification by small protein conjugation#GO:0032446 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=24880|UniProtKB=O95274 O95274 LYPD3 PTHR10624:SF8 UROKINASE PLASMINOGEN ACTIVATOR SURFACE RECEPTOR-RELATED LY6_PLAUR DOMAIN-CONTAINING PROTEIN 3 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=29958|UniProtKB=Q8NEX9 Q8NEX9 SDR9C7 PTHR43313:SF5 SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY 9C MEMBER 7 all-trans-retinol dehydrogenase (NAD+) activity#GO:0004745;oxidoreductase activity#GO:0016491;alcohol dehydrogenase (NAD+) activity#GO:0004022;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455 cellular process#GO:0009987;biological regulation#GO:0065007;hormone metabolic process#GO:0042445;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;alcohol metabolic process#GO:0006066;diterpenoid metabolic process#GO:0016101;retinoid metabolic process#GO:0001523;regulation of hormone levels#GO:0010817;primary metabolic process#GO:0044238;small molecule metabolic process#GO:0044281;terpenoid metabolic process#GO:0006721;retinol metabolic process#GO:0042572;olefinic compound metabolic process#GO:0120254;regulation of biological quality#GO:0065008;isoprenoid metabolic process#GO:0006720 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=24490|UniProtKB=Q96DR7 Q96DR7 ARHGEF26 PTHR12845:SF4 GUANINE NUCLEOTIDE EXCHANGE FACTOR RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 26 molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;guanyl-nucleotide exchange factor activity#GO:0005085 regulation of actin filament-based process#GO:0032970;biological regulation#GO:0065007;regulation of actin cytoskeleton organization#GO:0032956;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043 protein-binding activity modulator#PC00095;G-protein modulator#PC00022;guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=6282|UniProtKB=Q9Y2U2 Q9Y2U2 KCNK7 PTHR11003:SF31 POTASSIUM CHANNEL, SUBFAMILY K POTASSIUM CHANNEL SUBFAMILY K MEMBER 7 monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated monoatomic ion channel activity#GO:0005244;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;outward rectifier potassium channel activity#GO:0015271;potassium channel activity#GO:0005267;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803 transport#GO:0006810;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;metal ion transport#GO:0030001 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=14054|UniProtKB=Q9P015 Q9P015 MRPL15 PTHR12934:SF15 50S RIBOSOMAL PROTEIN L15 LARGE RIBOSOMAL SUBUNIT PROTEIN UL15M structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 membrane-enclosed lumen#GO:0031974;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;mitochondrial large ribosomal subunit#GO:0005762;membraneless organelle#GO:0043228;organelle lumen#GO:0043233;ribosome#GO:0005840;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organellar ribosome#GO:0000313;mitochondrial ribosome#GO:0005761;membrane-bounded organelle#GO:0043227 ribosomal protein#PC00202 HUMAN|HGNC=52383|UniProtKB=P0DQD5 P0DQD5 NPY4R2 PTHR24235:SF25 NEUROPEPTIDE Y RECEPTOR NEUROPEPTIDE Y RECEPTOR TYPE 4-RELATED neuropeptide receptor activity#GO:0008188;G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;signaling receptor activity#GO:0038023 signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;neuropeptide signaling pathway#GO:0007218;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=13800|UniProtKB=Q9GZZ6 Q9GZZ6 CHRNA10 PTHR18945:SF889 NEUROTRANSMITTER GATED ION CHANNEL NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-10 ligand-gated monoatomic ion channel activity#GO:0015276;molecular transducer activity#GO:0060089;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;gated channel activity#GO:0022836;postsynaptic neurotransmitter receptor activity#GO:0098960;transmembrane signaling receptor activity#GO:0004888;monoatomic cation transmembrane transporter activity#GO:0008324;neurotransmitter receptor activity#GO:0030594;transporter activity#GO:0005215;monoatomic ion channel activity#GO:0005216;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion transmembrane transporter activity#GO:0015075;signaling receptor activity#GO:0038023 calcium ion transport#GO:0006816;regulation of membrane potential#GO:0042391;cellular process#GO:0009987;detection of stimulus involved in sensory perception#GO:0050906;synaptic signaling#GO:0099536;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;nervous system process#GO:0050877;signaling#GO:0023052;sensory perception of sound#GO:0007605;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;response to abiotic stimulus#GO:0009628;system process#GO:0003008;response to external stimulus#GO:0009605;establishment of localization#GO:0051234;transport#GO:0006810;detection of mechanical stimulus#GO:0050982;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;synaptic transmission, cholinergic#GO:0007271;multicellular organismal process#GO:0032501;response to mechanical stimulus#GO:0009612;detection of stimulus#GO:0051606;localization#GO:0051179;cell communication#GO:0007154;monoatomic cation transport#GO:0006812;sensory perception of mechanical stimulus#GO:0050954;sensory perception#GO:0007600;trans-synaptic signaling#GO:0099537;metal ion transport#GO:0030001;membrane depolarization#GO:0051899;anterograde trans-synaptic signaling#GO:0098916;chemical synaptic transmission#GO:0007268 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;protein-containing complex#GO:0032991;synaptic membrane#GO:0097060;cell junction#GO:0030054;transporter complex#GO:1990351;membrane protein complex#GO:0098796;postsynapse#GO:0098794;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;transmembrane transporter complex#GO:1902495 ligand-gated ion channel#PC00141 Nicotinic acetylcholine receptor signaling pathway#P00044>alpha#P01088;Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086 HUMAN|HGNC=23818|UniProtKB=Q14684 Q14684 RRP1B PTHR13026:SF2 NNP-1 PROTEIN NOVEL NUCLEAR PROTEIN 1 NOP52 RIBOSOMAL RNA PROCESSING PROTEIN 1 HOMOLOG B transcription coactivator activity#GO:0003713;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 nucleus#GO:0005634;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 HUMAN|HGNC=29812|UniProtKB=Q96C86 Q96C86 DCPS PTHR12978:SF0 HISTIDINE TRIAD HIT PROTEIN MEMBER M7GPPPX DIPHOSPHATASE nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;nucleic acid catabolic process#GO:0141188;nucleobase-containing compound catabolic process#GO:0034655;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;positive regulation of catabolic process#GO:0009896;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;positive regulation of RNA metabolic process#GO:0051254;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of mRNA catabolic process#GO:0061014;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA decapping#GO:0110154;regulation of RNA metabolic process#GO:0051252;regulation of RNA stability#GO:0043487;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;RNA destabilization#GO:0050779;regulation of mRNA metabolic process#GO:1903311;metabolic process#GO:0008152;positive regulation of mRNA metabolic process#GO:1903313;macromolecule catabolic process#GO:0009057;mRNA destabilization#GO:0061157;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;regulation of mRNA stability#GO:0043488;regulation of biological process#GO:0050789;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of biological quality#GO:0065008;positive regulation of metabolic process#GO:0009893;RNA metabolic process#GO:0016070;RNA catabolic process#GO:0006401 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;P-body#GO:0000932;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;supramolecular complex#GO:0099080;organelle#GO:0043226;ribonucleoprotein granule#GO:0035770;nucleus#GO:0005634 hydrolase#PC00121 HUMAN|HGNC=23825|UniProtKB=Q86TA1 Q86TA1 MOB3B PTHR22599:SF22 MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB MOB KINASE ACTIVATOR 3B kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;protein kinase regulator activity#GO:0019887;protein kinase activator activity#GO:0030295;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;kinase activator activity#GO:0019209 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cell communication#GO:0007154 nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 kinase activator#PC00138 HUMAN|HGNC=26989|UniProtKB=Q6ZNG9 Q6ZNG9 KRABD2 PTHR45935:SF2 PROTEIN ZBED8-RELATED KRAB DOMAIN-CONTAINING PROTEIN 2 HUMAN|HGNC=32971|UniProtKB=Q6A163 Q6A163 KRT39 PTHR23239:SF106 INTERMEDIATE FILAMENT KERATIN, TYPE I CYTOSKELETAL 39 structural molecule activity#GO:0005198 anatomical structure development#GO:0048856;tissue morphogenesis#GO:0048729;supramolecular fiber organization#GO:0097435;animal gross anatomical part developmental process#GO:0160108;intermediate filament-based process#GO:0045103;intermediate filament organization#GO:0045109;intermediate filament cytoskeleton organization#GO:0045104;cell differentiation#GO:0030154;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;morphogenesis of an epithelium#GO:0002009;developmental process#GO:0032502;epithelial cell differentiation#GO:0030855;tissue development#GO:0009888;epithelium development#GO:0060429;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular process#GO:0009987 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;intermediate filament#GO:0005882;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;organelle#GO:0043226;supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232 intermediate filament#PC00129 HUMAN|HGNC=3278|UniProtKB=O15371 O15371 EIF3D PTHR12399:SF0 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 7 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT D translation factor activity#GO:0180051;translation initiation factor activity#GO:0003743 metabolic process#GO:0008152;translational initiation#GO:0006413;translation#GO:0006412;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058 eukaryotic translation initiation factor 3 complex#GO:0005852;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 translation initiation factor#PC00224 HUMAN|HGNC=11737|UniProtKB=Q8IWB6 Q8IWB6 TEX14 PTHR23060:SF1 TESTIS EXPRESSED GENE 14 INACTIVE SERINE_THREONINE-PROTEIN KINASE TEX14 organelle fission#GO:0048285;cell communication#GO:0007154;localization#GO:0051179;intracellular signal transduction#GO:0035556;organelle localization#GO:0051640;negative regulation of chromosome organization#GO:2001251;mitotic sister chromatid separation#GO:0051306;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;mitotic cell cycle#GO:0000278;reproductive process#GO:0022414;negative regulation of cellular component organization#GO:0051129;mitotic cell cycle checkpoint signaling#GO:0007093;regulation of mitotic sister chromatid separation#GO:0010965;regulation of mitotic nuclear division#GO:0007088;regulation of chromosome organization#GO:0033044;negative regulation of cell cycle process#GO:0010948;male gamete generation#GO:0048232;negative regulation of nuclear division#GO:0051784;regulation of nuclear division#GO:0051783;mitotic sister chromatid segregation#GO:0000070;regulation of mitotic cell cycle#GO:0007346;regulation of mitotic cell cycle phase transition#GO:1901990;negative regulation of mitotic cell cycle#GO:0045930;extracellular structure organization#GO:0043062;negative regulation of mitotic sister chromatid separation#GO:2000816;gamete generation#GO:0007276;regulation of sister chromatid segregation#GO:0033045;signaling#GO:0023052;meiotic cell cycle process#GO:1903046;cellular component organization#GO:0016043;chromosome separation#GO:0051304;negative regulation of cell cycle#GO:0045786;metaphase chromosome alignment#GO:0051310;chromosome segregation#GO:0007059;regulation of chromosome segregation#GO:0051983;cell cycle checkpoint signaling#GO:0000075;chromosome localization#GO:0050000;regulation of cell cycle process#GO:0010564;attachment of spindle microtubules to kinetochore#GO:0008608;mitotic spindle assembly checkpoint signaling#GO:0007094;regulation of mitotic sister chromatid segregation#GO:0033047;multicellular organismal reproductive process#GO:0048609;sexual reproduction#GO:0019953;regulation of cellular process#GO:0050794;negative regulation of organelle organization#GO:0010639;regulation of cell cycle phase transition#GO:1901987;cell cycle#GO:0007049;cellular response to stimulus#GO:0051716;negative regulation of mitotic metaphase/anaphase transition#GO:0045841;meiotic nuclear division#GO:0140013;chromosome organization#GO:0051276;mitotic cell cycle process#GO:1903047;negative regulation of chromosome separation#GO:1905819;negative regulation of cellular process#GO:0048523;regulation of mitotic metaphase/anaphase transition#GO:0030071;biological regulation#GO:0065007;nuclear division#GO:0000280;response to stimulus#GO:0050896;regulation of cellular component organization#GO:0051128;regulation of cell cycle#GO:0051726;sister chromatid segregation#GO:0000819;nuclear chromosome segregation#GO:0098813;negative regulation of cell cycle phase transition#GO:1901988;negative regulation of biological process#GO:0048519;regulation of organelle organization#GO:0033043;cell cycle process#GO:0022402;mitotic nuclear division#GO:0140014;regulation of biological process#GO:0050789;negative regulation of mitotic nuclear division#GO:0045839;cellular component organization or biogenesis#GO:0071840;negative regulation of chromosome segregation#GO:0051985;meiotic cell cycle#GO:0051321;negative regulation of metaphase/anaphase transition of cell cycle#GO:1902100;negative regulation of mitotic sister chromatid segregation#GO:0033048;negative regulation of mitotic cell cycle phase transition#GO:1901991;regulation of chromosome separation#GO:1905818;male meiotic nuclear division#GO:0007140;negative regulation of sister chromatid segregation#GO:0033046;organelle organization#GO:0006996;cellular process#GO:0009987;signal transduction#GO:0007165 chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;chromosome, centromeric region#GO:0000775;condensed chromosome#GO:0000793;intracellular membraneless organelle#GO:0043232;supramolecular complex#GO:0099080;organelle#GO:0043226;cellular anatomical structure#GO:0110165;kinetochore#GO:0000776;midbody#GO:0030496;condensed chromosome, centromeric region#GO:0000779;chromosome#GO:0005694 HUMAN|HGNC=12975|UniProtKB=Q99676 Q99676 ZNF184 PTHR24377:SF667 IP01015P-RELATED ZINC FINGER PROTEIN 184 RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=17052|UniProtKB=O94979 O94979 SEC31A PTHR13923:SF23 SEC31-RELATED PROTEIN PROTEIN TRANSPORT PROTEIN SEC31A membrane organization#GO:0061024;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;organelle organization#GO:0006996;vesicle budding from membrane#GO:0006900;vesicle organization#GO:0016050;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;transport#GO:0006810;Golgi vesicle transport#GO:0048193;intracellular transport#GO:0046907;cellular component organization#GO:0016043;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;localization#GO:0051179;COPII-coated vesicle budding#GO:0090114 vesicle membrane#GO:0012506;membrane#GO:0016020;transport vesicle#GO:0030133;transport vesicle membrane#GO:0030658;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;vesicle coat#GO:0030120;cytoplasm#GO:0005737;ER to Golgi transport vesicle membrane#GO:0012507;endoplasmic reticulum exit site#GO:0070971;endoplasmic reticulum#GO:0005783;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;coated vesicle membrane#GO:0030662;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;coated membrane#GO:0048475;COPII-coated ER to Golgi transport vesicle#GO:0030134;membrane coat#GO:0030117;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;coated vesicle#GO:0030135 vesicle coat protein#PC00235;membrane traffic protein#PC00150 HUMAN|HGNC=2582|UniProtKB=P35663 P35663 CYLC1 PTHR16742:SF1 CYCLICIN CYLICIN-1 secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;acrosomal vesicle#GO:0001669;vacuole#GO:0005773;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;secretory vesicle#GO:0099503 structural protein#PC00211 HUMAN|HGNC=9623|UniProtKB=P06454 P06454 PTMA PTHR22745:SF0 PROTHYMOSIN ALPHA PROTHYMOSIN ALPHA protein binding#GO:0005515;binding#GO:0005488;histone binding#GO:0042393 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;negative regulation of programmed cell death#GO:0043069;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;negative regulation of apoptotic process#GO:0043066;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;negative regulation of cellular process#GO:0048523;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of apoptotic process#GO:0042981;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of RNA metabolic process#GO:0051252 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=13089|UniProtKB=P17036 P17036 ZNF3 PTHR24381:SF410 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 3 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=26321|UniProtKB=Q53RT3 Q53RT3 ASPRV1 PTHR37006:SF1 RETROVIRAL-LIKE ASPARTIC PROTEASE 1 RETROVIRAL-LIKE ASPARTIC PROTEASE 1 viral or transposable element protein#PC00237 HUMAN|HGNC=26401|UniProtKB=Q8N4S9 Q8N4S9 MARVELD2 PTHR23288:SF3 OCCLUDIN AND RNA POLYMERASE II ELONGATION FACTOR ELL MARVEL DOMAIN-CONTAINING PROTEIN 2 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676 regulation of transcription elongation by RNA polymerase II#GO:0034243;nucleic acid biosynthetic process#GO:0141187;regulation of DNA-templated transcription elongation#GO:0032784;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;RNA metabolic process#GO:0016070;regulation of biological process#GO:0050789;cell junction assembly#GO:0034329;cellular component organization#GO:0016043;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of DNA-templated transcription, elongation#GO:0032786;snRNA transcription#GO:0009301;cell-cell junction assembly#GO:0007043;metabolic process#GO:0008152;positive regulation of transcription by RNA polymerase II#GO:0045944;nucleobase-containing compound biosynthetic process#GO:0034654;cellular component organization or biogenesis#GO:0071840;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;cellular component assembly#GO:0022607;positive regulation of macromolecule metabolic process#GO:0010604;gene expression#GO:0010467;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;snRNA metabolic process#GO:0016073;regulation of DNA-templated transcription#GO:0006355;snRNA transcription by RNA polymerase II#GO:0042795;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;positive regulation of RNA metabolic process#GO:0051254;DNA-templated transcription#GO:0006351;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;cell junction organization#GO:0034330;transcription by RNA polymerase II#GO:0006366;cell-cell junction organization#GO:0045216;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;macromolecule biosynthetic process#GO:0009059;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893 apical part of cell#GO:0045177;apical junction complex#GO:0043296;tight junction#GO:0070160;nuclear protein-containing complex#GO:0140513;cell junction#GO:0030054;nucleus#GO:0005634;cell periphery#GO:0071944;membrane-enclosed lumen#GO:0031974;cell-cell junction#GO:0005911;membrane#GO:0016020;cytoplasm#GO:0005737;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;plasma membrane region#GO:0098590;bicellular tight junction#GO:0005923;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;anchoring junction#GO:0070161;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;vesicle#GO:0031982;organelle lumen#GO:0043233;apical plasma membrane#GO:0016324;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;transcription elongation factor complex#GO:0008023;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226 general transcription factor#PC00259 HUMAN|HGNC=21727|UniProtKB=Q67FW5 Q67FW5 QTGAL PTHR22916:SF73 GLYCOSYLTRANSFERASE QUEUOSINE-TRNA GALACTOSYLTRANSFERASE UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;catalytic activity, acting on RNA#GO:0140098;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a nucleic acid#GO:0140640;hexosyltransferase activity#GO:0016758;catalytic activity, acting on a tRNA#GO:0140101;galactosyltransferase activity#GO:0008378 macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;gene expression#GO:0010467;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;RNA biosynthetic process#GO:0032774;tRNA modification#GO:0006400;tRNA wobble base modification#GO:0002097;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 transferase#PC00220;glycosyltransferase#PC00111 HUMAN|HGNC=26798|UniProtKB=Q8N8R7 Q8N8R7 ARL14EP PTHR46536:SF1 ARL14 EFFECTOR PROTEIN ARL14 EFFECTOR PROTEIN HUMAN|HGNC=21735|UniProtKB=Q9UPM6 Q9UPM6 LHX6 PTHR24208:SF121 LIM/HOMEOBOX PROTEIN LHX LIM_HOMEOBOX PROTEIN LHX6 DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 central nervous system neuron differentiation#GO:0021953;developmental process#GO:0032502;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;multicellular organismal process#GO:0032501;brain development#GO:0007420;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;neuron differentiation#GO:0030182;animal organ development#GO:0048513;multicellular organism development#GO:0007275;cellular process#GO:0009987;head development#GO:0060322;nervous system development#GO:0007399;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;neuron development#GO:0048666;regulation of biological process#GO:0050789;forebrain development#GO:0030900;central nervous system development#GO:0007417;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;cell development#GO:0048468 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 HUMAN|HGNC=25649|UniProtKB=Q9NUL5 Q9NUL5 SHFL PTHR16135:SF2 REPRESSOR OF YIELD OF DENV PROTEIN SHIFTLESS ANTIVIRAL INHIBITOR OF RIBOSOMAL FRAMESHIFTING PROTEIN mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;ribonucleoprotein complex binding#GO:0043021;ribosome binding#GO:0043022;protein-containing complex binding#GO:0044877 innate immune response#GO:0045087;response to external stimulus#GO:0009605;defense response#GO:0006952;immune system process#GO:0002376;response to stimulus#GO:0050896;defense response to other organism#GO:0098542;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to other organism#GO:0051707;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;immune response#GO:0006955;defense response to symbiont#GO:0140546 HUMAN|HGNC=6206|UniProtKB=P17535 P17535 JUND PTHR11462:SF7 JUN TRANSCRIPTION FACTOR-RELATED TRANSCRIPTION FACTOR JUND transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;regulation of cell cycle#GO:0051726;positive regulation of transcription by RNA polymerase II#GO:0045944;response to hormone#GO:0009725;positive regulation of biological process#GO:0048518;response to lipid#GO:0033993;positive regulation of macromolecule metabolic process#GO:0010604;response to chemical#GO:0042221;response to steroid hormone#GO:0048545;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;regulation of cell population proliferation#GO:0042127;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141 transcription regulator complex#GO:0005667;protein-containing complex#GO:0032991 basic leucine zipper transcription factor#PC00056;DNA-binding transcription factor#PC00218 Gonadotropin-releasing hormone receptor pathway#P06664>Jund#P06764;TGF-beta signaling pathway#P00052>Co-activators corepressors#P01282;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>AP-1#P00838 HUMAN|HGNC=26703|UniProtKB=Q8N205 Q8N205 SYNE4 PTHR21640:SF1 FAMILY NOT NAMED NESPRIN-4 HUMAN|HGNC=2256|UniProtKB=Q9UQ03 Q9UQ03 CORO2B PTHR10856:SF17 CORONIN CORONIN-2B protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin filament binding#GO:0051015;actin binding#GO:0003779 cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;focal adhesion assembly#GO:0048041;cell-substrate junction organization#GO:0150115;cellular component organization or biogenesis#GO:0071840;actin filament organization#GO:0007015;cellular component organization#GO:0016043;cell-substrate junction assembly#GO:0007044;cell junction assembly#GO:0034329;cell junction organization#GO:0034330;actin cytoskeleton organization#GO:0030036;actin filament-based process#GO:0030029;cell adhesion#GO:0007155;cell-matrix adhesion#GO:0007160;cell-substrate adhesion#GO:0031589;supramolecular fiber organization#GO:0097435 supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;membrane#GO:0016020;cell periphery#GO:0071944;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;actin filament#GO:0005884;organelle#GO:0043226;cellular anatomical structure#GO:0110165;actin cytoskeleton#GO:0015629;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HUMAN|HGNC=19733|UniProtKB=Q96QU8 Q96QU8 XPO6 PTHR21452:SF4 EXPORTIN-6 EXPORTIN-6 nucleocytoplasmic transport#GO:0006913;protein transport#GO:0015031;nuclear export#GO:0051168;nuclear transport#GO:0051169;cellular localization#GO:0051641;localization#GO:0051179;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;macromolecule localization#GO:0033036;protein export from nucleus#GO:0006611;intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234 HUMAN|HGNC=6550|UniProtKB=O14960 O14960 LECT2 PTHR11329:SF0 LEUKOCYTE CELL-DERIVED CHEMOTAXIN 2 LEUKOCYTE CELL-DERIVED CHEMOTAXIN-2 cytokine#PC00083;chemokine#PC00074 HUMAN|HGNC=8811|UniProtKB=Q15120 Q15120 PDK3 PTHR11947:SF21 PYRUVATE DEHYDROGENASE KINASE [PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE ISOZYME 3, MITOCHONDRIAL protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740 regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of carbohydrate metabolic process#GO:0006109;regulation of lipid metabolic process#GO:0019216;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=34444|UniProtKB=Q3C1V1 Q3C1V1 C11orf91 PTHR36288:SF1 SIMILAR TO RIKEN CDNA A930018P22 SIMILAR TO HUMAN CHROMOSOME 11 OPEN READING FRAME 91 HUMAN|HGNC=14620|UniProtKB=Q9UGI8 Q9UGI8 TES PTHR24211:SF1 LIM DOMAIN-CONTAINING PROTEIN TESTIN cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=11571|UniProtKB=Q13148 Q13148 TARDBP PTHR48033:SF9 RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN TAR DNA-BINDING PROTEIN 43 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007 nucleus#GO:0005634;chromatin#GO:0000785;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228;chromosome#GO:0005694;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 RNA metabolism protein#PC00031 HUMAN|HGNC=21874|UniProtKB=Q96ME1 Q96ME1 FBXL18 PTHR16134:SF19 F-BOX/TPR REPEAT PROTEIN POF3 F-BOX_LRR-REPEAT PROTEIN 18 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;enzyme-substrate adaptor activity#GO:0140767;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;metabolic process#GO:0008152;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511 transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular protein-containing complex#GO:0140535;SCF ubiquitin ligase complex#GO:0019005;cullin-RING ubiquitin ligase complex#GO:0031461;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=6968|UniProtKB=Q9UBS3 Q9UBS3 DNAJB9 PTHR44360:SF1 DNAJ HOMOLOG SUBFAMILY B MEMBER 9 DNAJ HOMOLOG SUBFAMILY B MEMBER 9 binding#GO:0005488;protein-folding chaperone binding#GO:0051087;protein binding#GO:0005515 macromolecule metabolic process#GO:0043170;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;proteasomal protein catabolic process#GO:0010498;response to chemical#GO:0042221;cellular process#GO:0009987;response to stress#GO:0006950;ERAD pathway#GO:0036503;protein metabolic process#GO:0019538;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;response to endoplasmic reticulum stress#GO:0034976;catabolic process#GO:0009056;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;endoplasmic reticulum lumen#GO:0005788;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 chaperone#PC00072 HUMAN|HGNC=28444|UniProtKB=Q69YG0 Q69YG0 TMEM42 PTHR31965:SF1 TRANSMEMBRANE PROTEIN 42 TRANSMEMBRANE PROTEIN 42 HUMAN|HGNC=26456|UniProtKB=Q96N23 Q96N23 CFAP54 PTHR33487:SF1 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 54 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 54 cellular component assembly#GO:0022607;cell projection organization#GO:0030030;plasma membrane bounded cell projection organization#GO:0120036;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782;plasma membrane bounded cell projection assembly#GO:0120031;organelle assembly#GO:0070925 structural protein#PC00211 HUMAN|HGNC=17927|UniProtKB=Q9P0U3 Q9P0U3 SENP1 PTHR12606:SF30 SENTRIN/SUMO-SPECIFIC PROTEASE SENTRIN-SPECIFIC PROTEASE 1 hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234 post-translational protein modification#GO:0043687;cellular process#GO:0009987;protein modification process#GO:0036211;primary metabolic process#GO:0044238;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 protease#PC00190 HUMAN|HGNC=13911|UniProtKB=Q8IXT2 Q8IXT2 DMRTC2 PTHR12322:SF126 DOUBLESEX AND MAB-3 RELATED TRANSCRIPTION FACTOR DMRT DOUBLESEX- AND MAB-3-RELATED TRANSCRIPTION FACTOR C2 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 developmental process involved in reproduction#GO:0003006;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;reproductive process#GO:0022414;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;sex differentiation#GO:0007548;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218 HUMAN|HGNC=4193|UniProtKB=P30793 P30793 GCH1 PTHR11109:SF11 GTP CYCLOHYDROLASE I GTP CYCLOHYDROLASE 1 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;catalytic activity#GO:0003824 small molecule biosynthetic process#GO:0044283;alcohol metabolic process#GO:0006066;metabolic process#GO:0008152;cellular process#GO:0009987;alcohol biosynthetic process#GO:0046165;biosynthetic process#GO:0009058;pteridine-containing compound metabolic process#GO:0042558;small molecule metabolic process#GO:0044281 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 Tetrahydrofolate biosynthesis#P02742>GTP cyclohydrolase#P02951 HUMAN|HGNC=12327|UniProtKB=Q12815 Q12815 TROAP PTHR15289:SF3 TASTIN TASTIN HUMAN|HGNC=23062|UniProtKB=Q5GH72 Q5GH72 XKR7 PTHR16024:SF7 XK-RELATED PROTEIN XK-RELATED PROTEIN 7 lipid localization#GO:0010876;regulation of biological quality#GO:0065008;plasma membrane organization#GO:0007009;execution phase of apoptosis#GO:0097194;apoptotic process#GO:0006915;cellular component organization#GO:0016043;endocytosis#GO:0006897;membrane invagination#GO:0010324;cellular component organization or biogenesis#GO:0071840;apoptotic cell clearance#GO:0043277;phagocytosis, engulfment#GO:0006911;import into cell#GO:0098657;cellular process#GO:0009987;endomembrane system organization#GO:0010256;localization#GO:0051179;anatomical structure development#GO:0048856;cell death#GO:0008219;programmed cell death#GO:0012501;plasma membrane phospholipid scrambling#GO:0017121;lipid translocation#GO:0034204;organophosphate ester transport#GO:0015748;developmental process#GO:0032502;transport#GO:0006810;phagocytosis#GO:0006909;regulation of membrane lipid distribution#GO:0097035;establishment of localization#GO:0051234;macromolecule localization#GO:0033036;biological regulation#GO:0065007;phospholipid translocation#GO:0045332;membrane organization#GO:0061024;phospholipid transport#GO:0015914;lipid transport#GO:0006869 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 secondary carrier transporter#PC00258 HUMAN|HGNC=13851|UniProtKB=Q6R2W3 Q6R2W3 SCAND3 PTHR45935:SF15 PROTEIN ZBED8-RELATED SCAN DOMAIN-CONTAINING PROTEIN 3 HUMAN|HGNC=21555|UniProtKB=Q5T1H1 Q5T1H1 EYS PTHR24033:SF232 EGF-LIKE DOMAIN-CONTAINING PROTEIN PROTEIN EYES SHUT HOMOLOG structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=2318|UniProtKB=Q9HCH3 Q9HCH3 CPNE5 PTHR10857:SF51 COPINE COPINE-5 binding#GO:0005488;phospholipid binding#GO:0005543;lipid binding#GO:0008289 response to metal ion#GO:0010038;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;response to calcium ion#GO:0051592;response to chemical#GO:0042221;response to stimulus#GO:0050896 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 calcium-binding protein#PC00060 HUMAN|HGNC=16956|UniProtKB=Q96B01 Q96B01 RAD51AP1 PTHR15361:SF4 RAD51/NUKS-INTERACTING PROTEIN RAD51-ASSOCIATED PROTEIN 1 single-stranded DNA binding#GO:0003697;nucleic acid binding#GO:0003676;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677 DNA damage response#GO:0006974;DNA recombination#GO:0006310;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;response to stress#GO:0006950;interstrand cross-link repair#GO:0036297;nucleobase-containing compound metabolic process#GO:0006139;cellular response to stress#GO:0033554;recombinational repair#GO:0000725;double-strand break repair via homologous recombination#GO:0000724;cellular response to stimulus#GO:0051716;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;response to stimulus#GO:0050896 HUMAN|HGNC=4632|UniProtKB=P09488 P09488 GSTM1 PTHR11571:SF247 GLUTATHIONE S-TRANSFERASE GLUTATHIONE S-TRANSFERASE MU 1 transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;catalytic activity#GO:0003824;glutathione transferase activity#GO:0004364;transferase activity#GO:0016740 cellular process#GO:0009987;modified amino acid metabolic process#GO:0006575;glutathione metabolic process#GO:0006749;sulfur compound metabolic process#GO:0006790;metabolic process#GO:0008152 transferase#PC00220 HUMAN|HGNC=9987|UniProtKB=O14593 O14593 RFXANK PTHR24124:SF4 ANKYRIN REPEAT FAMILY A DNA-BINDING PROTEIN RFXANK regulation of RNA metabolic process#GO:0051252;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of DNA-templated transcription#GO:0006355;positive regulation of RNA metabolic process#GO:0051254;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 protein-binding activity modulator#PC00095 HUMAN|HGNC=16267|UniProtKB=Q9UBV4 Q9UBV4 WNT16 PTHR12027:SF70 WNT RELATED PROTEIN WNT-16 receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;G protein-coupled receptor binding#GO:0001664;frizzled binding#GO:0005109;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;binding#GO:0005488;signaling receptor binding#GO:0005102;cytokine activity#GO:0005125;protein binding#GO:0005515;molecular function activator activity#GO:0140677 multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;neuron differentiation#GO:0030182;developmental process#GO:0032502;cell surface receptor signaling pathway#GO:0007166;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;nervous system development#GO:0007399;signal transduction#GO:0007165;cellular process#GO:0009987;canonical Wnt signaling pathway#GO:0060070;cell communication#GO:0007154;anatomical structure development#GO:0048856;cell fate commitment#GO:0045165;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;Wnt signaling pathway#GO:0016055;response to stimulus#GO:0050896;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 Cadherin signaling pathway#P00012>Wnt#P00474;Wnt signaling pathway#P00057>Wnt#P01444;Alzheimer disease-presenilin pathway#P00004>Wnt#P00142 HUMAN|HGNC=4131|UniProtKB=Q9HCQ5 Q9HCQ5 GALNT9 PTHR11675:SF28 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 9 polypeptide N-acetylgalactosaminyltransferase activity#GO:0004653;acetylgalactosaminyltransferase activity#GO:0008376;glycosyltransferase activity#GO:0016757;catalytic activity, acting on a protein#GO:0140096;UDP-glycosyltransferase activity#GO:0008194;transferase activity#GO:0016740;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein O-linked glycosylation#GO:0006493;biosynthetic process#GO:0009058 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 transferase#PC00220;glycosyltransferase#PC00111 HUMAN|HGNC=9635|UniProtKB=Q12974 Q12974 PTP4A2 PTHR23339:SF65 TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE PROTEIN TYROSINE PHOSPHATASE TYPE IVA 2 protein tyrosine phosphatase activity#GO:0004725;hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HUMAN|HGNC=15986|UniProtKB=Q9H9Z2 Q9H9Z2 LIN28A PTHR46109:SF2 PROTEIN LIN-28 PROTEIN LIN-28 HOMOLOG A mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;pre-miRNA processing#GO:0031054;macromolecule biosynthetic process#GO:0009059;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulatory ncRNA-mediated gene silencing#GO:0031047;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulatory ncRNA processing#GO:0070918;macromolecule metabolic process#GO:0043170;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;miRNA processing#GO:0035196;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;RNA processing#GO:0006396;gene expression#GO:0010467;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031 HUMAN|HGNC=9993|UniProtKB=O94810 O94810 RGS11 PTHR45746:SF3 LP21163P REGULATOR OF G PROTEIN SIGNALING 11 enzyme activator activity#GO:0008047;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234 biological regulation#GO:0065007;response to chemical#GO:0042221;cellular response to nitrogen compound#GO:1901699;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987;G protein-coupled dopamine receptor signaling pathway#GO:0007212;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to nitrogen compound#GO:1901698;cell communication#GO:0007154;response to oxygen-containing compound#GO:1901700;G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887 cell projection#GO:0042995;plasma membrane#GO:0005886;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020;intracellular anatomical structure#GO:0005622 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>RGS#P00731;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>RGS#P00704 HUMAN|HGNC=29377|UniProtKB=Q5H9K5 Q5H9K5 ZMAT1 PTHR46742:SF2 LYSINE-RICH COILED-COIL PROTEIN 1 ZINC FINGER MATRIN-TYPE PROTEIN 1 HUMAN|HGNC=31908|UniProtKB=A6NDE8 A6NDE8 GAGE12H PTHR14047:SF30 P ANTIGEN FAMILY MEMBER 5-RELATED G ANTIGEN 1-RELATED HUMAN|HGNC=14508|UniProtKB=P82650 P82650 MRPS22 PTHR13071:SF4 MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S22 SMALL RIBOSOMAL SUBUNIT PROTEIN MS22 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 mitochondrial small ribosomal subunit#GO:0005763;membraneless organelle#GO:0043228;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;membrane-enclosed lumen#GO:0031974;mitochondrial ribosome#GO:0005761;organellar ribosome#GO:0000313;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;small ribosomal subunit#GO:0015935;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;ribosome#GO:0005840;mitochondrion#GO:0005739 ribosomal protein#PC00202 HUMAN|HGNC=24042|UniProtKB=Q9GZV5 Q9GZV5 WWTR1 PTHR17616:SF6 YES-ASSOCIATED PROTEIN YAP1 FAMILY MEMBER WW DOMAIN-CONTAINING TRANSCRIPTION REGULATOR PROTEIN 1 transcription coactivator activity#GO:0003713;transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 positive regulation of transcription by RNA polymerase II#GO:0045944;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of canonical Wnt signaling pathway#GO:0060828;hippo signaling#GO:0035329;positive regulation of macromolecule metabolic process#GO:0010604;regulation of signaling#GO:0023051;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;signaling#GO:0023052;regulation of Wnt signaling pathway#GO:0030111;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cell differentiation#GO:0045595;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of signal transduction#GO:0009966;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;intracellular signal transduction#GO:0035556;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;cell communication#GO:0007154;regulation of DNA-templated transcription#GO:0006355;cellular response to stimulus#GO:0051716;regulation of developmental process#GO:0050793;positive regulation of RNA metabolic process#GO:0051254;regulation of cell communication#GO:0010646;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 transcription cofactor#PC00217;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=30006|UniProtKB=Q9H6Y5 Q9H6Y5 MAGIX PTHR47646:SF1 PDZ DOMAIN-CONTAINING PROTEIN MAGIX PDZ DOMAIN-CONTAINING PROTEIN MAGIX HUMAN|HGNC=12116|UniProtKB=A0A0B4J234 A0A0B4J234 TRAV2 PTHR23267:SF374 IMMUNOGLOBULIN LIGHT CHAIN T CELL RECEPTOR ALPHA VARIABLE 2 immune response#GO:0006955;immune system process#GO:0002376;response to stimulus#GO:0050896 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=14795|UniProtKB=Q8NGJ6 Q8NGJ6 OR51A4 PTHR26450:SF168 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 51A2-RELATED olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=15426|UniProtKB=Q8NH05 Q8NH05 OR4Q3 PTHR48002:SF112 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 4Q3 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=3051|UniProtKB=Q99576 Q99576 TSC22D3 PTHR12348:SF24 TSC22 TSC22 DOMAIN FAMILY PROTEIN 3 molecular function inhibitor activity#GO:0140678;molecular function regulator activity#GO:0098772 regulation of apoptotic process#GO:0042981;negative regulation of cellular process#GO:0048523;negative regulation of programmed cell death#GO:0043069;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;negative regulation of immune system process#GO:0002683;biological regulation#GO:0065007;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;negative regulation of apoptotic process#GO:0043066 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=28401|UniProtKB=Q8TBY0 Q8TBY0 RBM46 PTHR21245:SF3 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN RNA-BINDING PROTEIN 46-RELATED mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031 HUMAN|HGNC=34415|UniProtKB=A6NC51 A6NC51 TMEM150B PTHR21324:SF3 FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED MODULATOR OF MACROAUTOPHAGY TMEM150B cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HUMAN|Gene=YM017_HUMAN|UniProtKB=A8MX80 A8MX80 PTHR15566:SF10 POM121-LIKE UPF0607 PROTEIN ENSP00000332738-RELATED HUMAN|HGNC=5634|UniProtKB=A0A075B7F0 A0A075B7F0 IGHV3OR16-10 PTHR23266:SF113 IMMUNOGLOBULIN HEAVY CHAIN IG-LIKE DOMAIN-CONTAINING PROTEIN binding#GO:0005488;antigen binding#GO:0003823 immune response#GO:0006955;adaptive immune response#GO:0002250;response to stimulus#GO:0050896;immune effector process#GO:0002252;immune system process#GO:0002376;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=14163|UniProtKB=Q9H0X4 Q9H0X4 FAM234A PTHR21419:SF7 FAMILY NOT NAMED PROTEIN FAM234A cell surface#GO:0009986;cellular anatomical structure#GO:0110165 HUMAN|HGNC=17425|UniProtKB=Q9GZQ6 Q9GZQ6 NPFFR1 PTHR24241:SF4 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR NEUROPEPTIDE FF RECEPTOR 1 molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 response to hormone#GO:0009725;signal transduction#GO:0007165;cellular process#GO:0009987;response to chemical#GO:0042221;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887;cell communication#GO:0007154;response to endogenous stimulus#GO:0009719;neuropeptide signaling pathway#GO:0007218;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;regulation of cellular process#GO:0050794;cellular response to hormone stimulus#GO:0032870;signaling#GO:0023052 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=11139|UniProtKB=Q9Y6H5 Q9Y6H5 SNCAIP PTHR22882:SF3 SYNPHILIN-1 SYNPHILIN-1 ubiquitin-like protein ligase binding#GO:0044389;binding#GO:0005488;enzyme binding#GO:0019899;protein binding#GO:0005515;ubiquitin protein ligase binding#GO:0031625 Parkinson disease#P00049>Synphilin#P01225 HUMAN|HGNC=20264|UniProtKB=Q5BKY1 Q5BKY1 LRRC10 PTHR16083:SF8 LEUCINE RICH REPEAT CONTAINING PROTEIN LEUCINE-RICH REPEAT-CONTAINING PROTEIN 10 protein binding#GO:0005515;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779 muscle structure development#GO:0061061;cell differentiation#GO:0030154;circulatory system development#GO:0072359;cell development#GO:0048468;muscle cell development#GO:0055001;muscle cell differentiation#GO:0042692;anatomical structure development#GO:0048856;striated muscle cell development#GO:0055002;system development#GO:0048731;muscle tissue development#GO:0060537;animal gross anatomical part developmental process#GO:0160108;tissue development#GO:0009888;multicellular organismal process#GO:0032501;heart development#GO:0007507;cardiac muscle cell differentiation#GO:0055007;cellular process#GO:0009987;cardiac muscle tissue development#GO:0048738;animal organ development#GO:0048513;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;striated muscle cell differentiation#GO:0051146;striated muscle tissue development#GO:0014706;developmental process#GO:0032502 cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;organelle#GO:0043226;supramolecular complex#GO:0099080;contractile muscle fiber#GO:0043292;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;myofibril#GO:0030016;membraneless organelle#GO:0043228;sarcomere#GO:0030017;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 scaffold/adaptor protein#PC00226 HUMAN|HGNC=11542|UniProtKB=Q16594 Q16594 TAF9 PTHR48068:SF3 TAF9 RNA POLYMERASE II, TATA BOX-BINDING PROTEIN (TBP)-ASSOCIATED FACTOR TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 9 structural molecule activity#GO:0005198;protein complex scaffold activity#GO:0140378 protein-containing complex assembly#GO:0065003;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;RNA biosynthetic process#GO:0032774;RNA polymerase II preinitiation complex assembly#GO:0051123;DNA-templated transcription#GO:0006351;DNA-templated transcription initiation#GO:0006352;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;transcription initiation at RNA polymerase II promoter#GO:0006367;cellular component biogenesis#GO:0044085;nucleobase-containing compound metabolic process#GO:0006139;protein-DNA complex assembly#GO:0065004;biosynthetic process#GO:0009058;cellular component assembly#GO:0022607;gene expression#GO:0010467;transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;protein-containing complex organization#GO:0043933;protein-DNA complex organization#GO:0071824;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170 nuclear protein-containing complex#GO:0140513;histone acetyltransferase complex#GO:0000123;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;transcription factor TFIID complex#GO:0005669;SAGA complex#GO:0000124;chromatin#GO:0000785;acetyltransferase complex#GO:1902493;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle#GO:0043229;protein acetyltransferase complex#GO:0031248;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle lumen#GO:0043233;membraneless organelle#GO:0043228;transcription regulator complex#GO:0005667;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;peptidase complex#GO:1905368;membrane-enclosed lumen#GO:0031974;RNA polymerase II transcription regulator complex#GO:0090575;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;SAGA-type complex#GO:0070461;RNA polymerase II, holoenzyme#GO:0016591;membrane-bounded organelle#GO:0043227;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;nuclear DNA-directed RNA polymerase complex#GO:0055029 Transcription regulation by bZIP transcription factor#P00055>TBP-associated factors#P01385;General transcription regulation#P00023>TBP-associated factors#P00658 HUMAN|HGNC=348|UniProtKB=P35869 P35869 AHR PTHR10649:SF9 ARYL HYDROCARBON RECEPTOR ARYL HYDROCARBON RECEPTOR transcription regulatory region nucleic acid binding#GO:0001067;nuclear receptor activity#GO:0004879;DNA binding#GO:0003677;molecular transducer activity#GO:0060089;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;signaling receptor activity#GO:0038023;sequence-specific DNA binding#GO:0043565 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;signaling receptor complex#GO:0043235;intracellular organelle#GO:0043229;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=16826|UniProtKB=Q15714 Q15714 TSC22D1 PTHR46745:SF1 TSC22 DOMAIN FAMILY PROTEIN 1 TSC22 DOMAIN FAMILY PROTEIN 1 negative regulation of cellular process#GO:0048523;regulation of apoptotic process#GO:0042981;regulation of cell population proliferation#GO:0042127;negative regulation of biological process#GO:0048519;positive regulation of cell population proliferation#GO:0008284;regulation of programmed cell death#GO:0043067;negative regulation of programmed cell death#GO:0043069;regulation of biological process#GO:0050789;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of cellular process#GO:0050794;negative regulation of apoptotic process#GO:0043066;biological regulation#GO:0065007 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cytosol#GO:0005829;nucleus#GO:0005634 HUMAN|HGNC=24127|UniProtKB=Q9BX73 Q9BX73 TM2D2 PTHR21016:SF4 BETA-AMYLOID BINDING PROTEIN-RELATED TM2 DOMAIN-CONTAINING PROTEIN 2 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023 positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;positive regulation of Notch signaling pathway#GO:0045747;regulation of cell communication#GO:0010646;signaling#GO:0023052;regulation of signaling#GO:0023051;regulation of Notch signaling pathway#GO:0008593;positive regulation of signaling#GO:0023056;cell communication#GO:0007154;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of cellular process#GO:0048522;positive regulation of response to stimulus#GO:0048584;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of response to stimulus#GO:0048583 HUMAN|HGNC=32935|UniProtKB=Q6T423 Q6T423 SLC22A25 PTHR24064:SF217 SOLUTE CARRIER FAMILY 22 MEMBER SOLUTE CARRIER FAMILY 22 MEMBER 25 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 transport#GO:0006810;cellular process#GO:0009987;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 secondary carrier transporter#PC00258 HUMAN|HGNC=11212|UniProtKB=Q07617 Q07617 SPAG1 PTHR45984:SF3 RNA (RNA) POLYMERASE II ASSOCIATED PROTEIN HOMOLOG SPERM-ASSOCIATED ANTIGEN 1 protein binding#GO:0005515;binding#GO:0005488;heat shock protein binding#GO:0031072 localization#GO:0051179;protein localization to organelle#GO:0033365;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;protein localization to mitochondrion#GO:0070585 cytosol#GO:0005829;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|Gene=SPDL3_HUMAN|UniProtKB=A6NJR5 A6NJR5 PTHR31156:SF15 WBSCR19-LIKE PROTEIN SPEEDY PROTEIN E10-RELATED HUMAN|HGNC=29295|UniProtKB=O60812 O60812 HNRNPCL1 PTHR13968:SF17 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN C-LIKE 1-RELATED RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031 HUMAN|HGNC=21679|UniProtKB=Q2MKA7 Q2MKA7 RSPO1 PTHR46987:SF5 NEUROHYPOPHYSIAL HORMONES, N-TERMINAL DOMAIN CONTAINING PROTEIN R-SPONDIN-1 protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488 regulation of canonical Wnt signaling pathway#GO:0060828;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of response to stimulus#GO:0048584;positive regulation of Wnt signaling pathway#GO:0030177;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of response to stimulus#GO:0048583;positive regulation of canonical Wnt signaling pathway#GO:0090263;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=5426|UniProtKB=P01569 P01569 IFNA5 PTHR11691:SF60 TYPE I INTERFERON INTERFERON ALPHA-5 signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;cytokine activity#GO:0005125;binding#GO:0005488;cytokine receptor binding#GO:0005126;signaling receptor binding#GO:0005102;protein binding#GO:0005515;molecular function activator activity#GO:0140677;protein-containing complex binding#GO:0044877 humoral immune response#GO:0006959;leukocyte activation involved in immune response#GO:0002366;natural killer cell activation#GO:0030101;cell surface receptor signaling pathway#GO:0007166;immune effector process#GO:0002252;B cell activation#GO:0042113;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;signal transduction#GO:0007165;lymphocyte activation involved in immune response#GO:0002285;defense response to symbiont#GO:0140546;cellular process#GO:0009987;lymphocyte activation#GO:0046649;response to cytokine#GO:0034097;response to chemical#GO:0042221;defense response to other organism#GO:0098542;T cell activation involved in immune response#GO:0002286;immune system process#GO:0002376;type I interferon-mediated signaling pathway#GO:0060337;B cell activation involved in immune response#GO:0002312;cell activation involved in immune response#GO:0002263;response to peptide#GO:1901652;T cell activation#GO:0042110;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052;innate immune response#GO:0045087;response to external stimulus#GO:0009605;defense response#GO:0006952;immune response#GO:0006955;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;adaptive immune response#GO:0002250;response to other organism#GO:0051707;cytokine-mediated signaling pathway#GO:0019221;cell activation#GO:0001775;cell communication#GO:0007154;response to nitrogen compound#GO:1901698;leukocyte activation#GO:0045321;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;response to external biotic stimulus#GO:0043207 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 interferon superfamily#PC00127;cytokine#PC00083 HUMAN|HGNC=28669|UniProtKB=Q8NE28 Q8NE28 STKLD1 PTHR24363:SF5 SERINE/THREONINE PROTEIN KINASE SERINE_THREONINE KINASE-LIKE DOMAIN-CONTAINING PROTEIN STKLD1 catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=6391|UniProtKB=Q14807 Q14807 KIF22 PTHR24115:SF1037 KINESIN-RELATED KINESIN-LIKE PROTEIN KIF22 microtubule motor activity#GO:0003777;ATP hydrolysis activity#GO:0016887;hydrolase activity#GO:0016787;polypeptide conformation or assembly isomerase activity#GO:0120544;microtubule binding#GO:0008017;ribonucleoside triphosphate phosphatase activity#GO:0017111;isomerase activity#GO:0016853;tubulin binding#GO:0015631;macromolecular conformation isomerase activity#GO:0120543;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;protein binding#GO:0005515;ATP-dependent activity#GO:0140657;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;cytoskeletal motor activity#GO:0003774;cytoskeletal protein binding#GO:0008092;hydrolase activity, acting on acid anhydrides#GO:0016817 microtubule-based process#GO:0007017;microtubule-based movement#GO:0007018;cellular process#GO:0009987 organelle#GO:0043226;cellular anatomical structure#GO:0110165;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;intracellular organelle#GO:0043229;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cytoskeleton#GO:0005856 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=12755|UniProtKB=Q9UNX4 Q9UNX4 WDR3 PTHR19853:SF0 WD REPEAT CONTAINING PROTEIN 3 WDR3 WD REPEAT-CONTAINING PROTEIN 3 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;snoRNA binding#GO:0030515 ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;biosynthetic process#GO:0009058;RNA processing#GO:0006396;maturation of SSU-rRNA#GO:0030490;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;ribosomal small subunit biogenesis#GO:0042274;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;small-subunit processome#GO:0032040;organelle lumen#GO:0043233;90S preribosome#GO:0030686;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;preribosome#GO:0030684 HUMAN|HGNC=19919|UniProtKB=Q8NCR6 Q8NCR6 SPMIP6 PTHR35664:SF1 SPERMATID-SPECIFIC MANCHETTE-RELATED PROTEIN 1 SPERM MICROTUBULE INNER PROTEIN 6 microtubule cytoskeleton#GO:0015630;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;perinuclear region of cytoplasm#GO:0048471;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=12519|UniProtKB=P55916 P55916 UCP3 PTHR45618:SF2 MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED MITOCHONDRIAL TRANSPORTER UCP3-RELATED transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;proton transmembrane transporter activity#GO:0015078;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075 establishment of localization in cell#GO:0051649;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;response to stress#GO:0006950;biological regulation#GO:0065007;response to temperature stimulus#GO:0009266;regulation of multicellular organismal process#GO:0051239;multicellular organismal process#GO:0032501;transport#GO:0006810;temperature homeostasis#GO:0001659;intracellular transport#GO:0046907;multicellular organismal-level homeostasis#GO:0048871;establishment of localization#GO:0051234;regulation of biological process#GO:0050789;positive regulation of multicellular organismal process#GO:0051240;response to abiotic stimulus#GO:0009628;homeostatic process#GO:0042592;response to stimulus#GO:0050896;mitochondrial transport#GO:0006839;response to cold#GO:0009409;adaptive thermogenesis#GO:1990845;mitochondrial transmembrane transport#GO:1990542;localization#GO:0051179;transmembrane transport#GO:0055085;cellular localization#GO:0051641 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740 secondary carrier transporter#PC00258;transporter#PC00227 HUMAN|HGNC=40030|UniProtKB=Q71RC9 Q71RC9 SMIM5 PTHR37344:SF1 SMALL INTEGRAL MEMBRANE PROTEIN 5 SMALL INTEGRAL MEMBRANE PROTEIN 5 HUMAN|HGNC=25068|UniProtKB=O43716 O43716 GATC PTHR15004:SF0 GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT C, MITOCHONDRIAL GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT C, MITOCHONDRIAL translation#GO:0006412;mitochondrial gene expression#GO:0140053;protein metabolic process#GO:0019538;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;protein biosynthetic process#GO:0160307;mitochondrial translation#GO:0032543;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;amino acid activation#GO:0043038;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;tRNA aminoacylation#GO:0043039;amino acid metabolic process#GO:0006520;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=4070|UniProtKB=Q9UBS5 Q9UBS5 GABBR1 PTHR10519:SF77 GABA-B RECEPTOR GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 1 molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;cellular process#GO:0009987;cell communication#GO:0007154;signaling#GO:0023052;biological regulation#GO:0065007;cell-cell signaling#GO:0007267 membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;signaling receptor complex#GO:0043235 G-protein coupled receptor#PC00021 GABA-B receptor II signaling#P05731>GABA-B receptor#P05756 HUMAN|Ensembl=ENSG00000284298.2|UniProtKB=A0A1B0GW55 A0A1B0GW55 LOC124905412 PTHR46123:SF3 MIX-TYPE HOMEOBOX GENE 1-RELATED DOUBLE HOMEOBOX PROTEIN 1-RELATED sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=25482|UniProtKB=Q9NWB6 Q9NWB6 ARGLU1 PTHR31711:SF1 ARGININE AND GLUTAMATE-RICH PROTEIN 1 ARGININE AND GLUTAMATE-RICH PROTEIN 1 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981 HUMAN|HGNC=13150|UniProtKB=Q15935 Q15935 ZNF77 PTHR24381:SF361 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 77 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=17192|UniProtKB=P58753 P58753 TIRAP PTHR22662:SF0 TIRAP TOLL_INTERLEUKIN-1 RECEPTOR DOMAIN-CONTAINING ADAPTER PROTEIN Toll receptor signaling pathway#P00054>TIRAP#P01350 HUMAN|HGNC=9784|UniProtKB=P61020 P61020 RAB5B PTHR24073:SF555 DRAB5-RELATED RAS-RELATED PROTEIN RAB-5B ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924 macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;endocytosis#GO:0006897;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810;import into cell#GO:0098657;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;protein transport#GO:0015031;intracellular protein localization#GO:0008104 vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;endocytic vesicle#GO:0030139;cell periphery#GO:0071944;membrane#GO:0016020;cytoplasm#GO:0005737;plasma membrane#GO:0005886;endomembrane system#GO:0012505 G-protein#PC00020;small GTPase#PC00208 HUMAN|HGNC=12290|UniProtKB=A0A0B4J1U4 A0A0B4J1U4 TRGV5 PTHR19256:SF65 T-CELL RECEPTOR GAMMA CHAIN T CELL RECEPTOR GAMMA VARIABLE 3-RELATED immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=2717|UniProtKB=Q16531 Q16531 DDB1 PTHR10644:SF27 DNA REPAIR/RNA PROCESSING CPSF FAMILY DNA DAMAGE-BINDING PROTEIN 1 nucleobase-containing compound metabolic process#GO:0006139;proteasomal protein catabolic process#GO:0010498;cellular process#GO:0009987;response to stress#GO:0006950;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;metabolic process#GO:0008152;DNA repair#GO:0006281;macromolecule catabolic process#GO:0009057;DNA metabolic process#GO:0006259;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;catabolic process#GO:0009056;response to stimulus#GO:0050896;modification-dependent protein catabolic process#GO:0019941;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;protein metabolic process#GO:0019538;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632 intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;site of DNA damage#GO:0090734;intracellular anatomical structure#GO:0005622;site of double-strand break#GO:0035861;chromosome#GO:0005694;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HUMAN|HGNC=11639|UniProtKB=P36402 P36402 TCF7 PTHR10373:SF33 TRANSCRIPTION FACTOR 7 FAMILY MEMBER TRANSCRIPTION FACTOR 7 RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 canonical Wnt signaling pathway#GO:0060070;cell communication#GO:0007154;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;Wnt signaling pathway#GO:0016055;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;signaling#GO:0023052;cell surface receptor signaling pathway#GO:0007166;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694;RNA polymerase II transcription regulator complex#GO:0090575;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 Wnt signaling pathway#P00057>TCF#P01437;Alzheimer disease-presenilin pathway#P00004>TCF/LEF#P00143;Wnt signaling pathway#P00057>Wnt Target Genes#G01558;Gonadotropin-releasing hormone receptor pathway#P06664>TCF#P06701;Angiogenesis#P00005>TCF#P00242 HUMAN|HGNC=29657|UniProtKB=Q8N108 Q8N108 MIER1 PTHR10865:SF24 METASTASIS-ASSOCIATED PROTEIN AND MESODERM INDUCTION EARLY RESPONSE PROTEIN MESODERM INDUCTION EARLY RESPONSE PROTEIN 1 transcription coregulator activity#GO:0003712;binding#GO:0005488;transcription corepressor activity#GO:0003714;enzyme binding#GO:0019899;transcription regulator activity#GO:0140110;protein binding#GO:0005515;histone deacetylase binding#GO:0042826 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=11590|UniProtKB=Q16650 Q16650 TBR1 PTHR11267:SF88 T-BOX PROTEIN-RELATED T-BOX BRAIN PROTEIN 1 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677 forebrain development#GO:0030900;cell differentiation#GO:0030154;central nervous system development#GO:0007417;regulation of cellular component organization#GO:0051128;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;cell fate commitment#GO:0045165;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;head development#GO:0060322;nervous system development#GO:0007399;cellular process#GO:0009987;regulation of neuron projection development#GO:0010975;animal organ development#GO:0048513;multicellular organism development#GO:0007275;cell fate specification#GO:0001708;neuron differentiation#GO:0030182;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;multicellular organismal process#GO:0032501;brain development#GO:0007420;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;neuron fate commitment#GO:0048663;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of plasma membrane bounded cell projection organization#GO:0120035;central nervous system neuron differentiation#GO:0021953;developmental process#GO:0032502;regulation of cell projection organization#GO:0031344 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694;nucleus#GO:0005634;chromatin#GO:0000785 immunoglobulin fold transcription factor#PC00251;Rel homology transcription factor#PC00252 HUMAN|HGNC=6826|UniProtKB=O00754 O00754 MAN2B1 PTHR11607:SF72 ALPHA-MANNOSIDASE LYSOSOMAL ALPHA-MANNOSIDASE hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 organelle#GO:0043226;cellular anatomical structure#GO:0110165;vacuole#GO:0005773;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;lysosome#GO:0005764;lytic vacuole#GO:0000323;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 glycosidase#PC00110;hydrolase#PC00121 HUMAN|HGNC=399|UniProtKB=P02768 P02768 ALB PTHR11385:SF15 SERUM ALBUMIN-RELATED ALBUMIN binding#GO:0005488;anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167;heterocyclic compound binding#GO:1901363 response to stimulus#GO:0050896;response to nutrient levels#GO:0031667 transfer/carrier protein#PC00219 HUMAN|HGNC=14972|UniProtKB=Q9Y5X2 Q9Y5X2 SNX8 PTHR46571:SF1 SORTING NEXIN-8 SORTING NEXIN-8 macromolecule localization#GO:0033036;retrograde transport, endosome to Golgi#GO:0042147;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;Golgi vesicle transport#GO:0048193;transport#GO:0006810;establishment of localization#GO:0051234;endosomal transport#GO:0016197;intracellular protein localization#GO:0008104;cytosolic transport#GO:0016482;cellular localization#GO:0051641;localization#GO:0051179;protein transport#GO:0015031 cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;cytoplasm#GO:0005737;membrane#GO:0016020;vesicle membrane#GO:0012506;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;early endosome membrane#GO:0031901;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;early endosome#GO:0005769;endosome#GO:0005768;endosome membrane#GO:0010008;intracellular organelle#GO:0043229 scaffold/adaptor protein#PC00226 HUMAN|HGNC=24846|UniProtKB=Q8NHY3 Q8NHY3 GAS2L2 PTHR46756:SF14 TRANSGELIN GAS2-LIKE PROTEIN 2 binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin filament binding#GO:0051015;actin binding#GO:0003779;protein binding#GO:0005515;protein-containing complex binding#GO:0044877 intracellular protein localization#GO:0008104;actin filament organization#GO:0007015;microtubule-based process#GO:0007017;regulation of microtubule polymerization or depolymerization#GO:0031110;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;macromolecule localization#GO:0033036;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;regulation of microtubule cytoskeleton organization#GO:0070507;protein localization to microtubule cytoskeleton#GO:0072698;actin filament-based process#GO:0030029;microtubule bundle formation#GO:0001578;regulation of microtubule-based process#GO:0032886;supramolecular fiber organization#GO:0097435;localization#GO:0051179;microtubule cytoskeleton organization#GO:0000226;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;cellular component organization#GO:0016043;protein localization to cytoskeleton#GO:0044380;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;protein localization to organelle#GO:0033365;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794 microtubule cytoskeleton#GO:0015630;actomyosin#GO:0042641;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;stress fiber#GO:0001725;cytoskeleton#GO:0005856;microtubule plus-end#GO:0035371;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;actin cytoskeleton#GO:0015629;microtubule end#GO:1990752;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;microtubule#GO:0005874;actin filament bundle#GO:0032432;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085 HUMAN|HGNC=5969|UniProtKB=P29459 P29459 IL12A PTHR48485:SF1 INTERLEUKIN-12 SUBUNIT BETA-RELATED INTERLEUKIN-12 SUBUNIT ALPHA growth factor receptor binding#GO:0070851;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;binding#GO:0005488;signaling receptor binding#GO:0005102;cytokine receptor binding#GO:0005126;cytokine activity#GO:0005125;molecular function activator activity#GO:0140677;protein binding#GO:0005515 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;response to chemical#GO:0042221;response to cytokine#GO:0034097;signaling#GO:0023052;biological regulation#GO:0065007;cytokine-mediated signaling pathway#GO:0019221;cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;response to peptide#GO:1901652 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;extracellular protein-containing complex#GO:0140392 Interleukin signaling pathway#P00036>Receptor subunit alpha#P00992;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>IL2#P00870 HUMAN|HGNC=18157|UniProtKB=Q15750 Q15750 TAB1 PTHR13832:SF533 PROTEIN PHOSPHATASE 2C TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1 phosphoprotein phosphatase activity#GO:0004721;protein serine/threonine phosphatase activity#GO:0004722;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 cell communication#GO:0007154;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052 protein phosphatase#PC00195 p38 MAPK pathway#P05918>TAB1#P06035;Toll receptor signaling pathway#P00054>TAB1#P01365;TGF-beta signaling pathway#P00052>TAB#P01290 HUMAN|HGNC=29014|UniProtKB=O15060 O15060 ZBTB39 PTHR24399:SF34 ZINC FINGER AND BTB DOMAIN-CONTAINING ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 39 transcription regulator activity#GO:0140110;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription repressor activity#GO:0001217;sequence-specific DNA binding#GO:0043565;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific double-stranded DNA binding#GO:1990837 negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of multicellular organismal process#GO:0051239;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cytokine production#GO:0001817;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218 HUMAN|HGNC=24456|UniProtKB=Q8NFT8 Q8NFT8 DNER PTHR24044:SF467 NOTCH LIGAND FAMILY MEMBER DELTA AND NOTCH-LIKE EPIDERMAL GROWTH FACTOR-RELATED RECEPTOR protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 intercellular signal molecule#PC00207 HUMAN|HGNC=11985|UniProtKB=O94826 O94826 TOMM70 PTHR46208:SF1 MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70 MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70 transporter#PC00227;primary active transporter#PC00068 HUMAN|HGNC=18486|UniProtKB=O15018 O15018 PDZD2 PTHR11324:SF16 IL16-RELATED PDZ DOMAIN-CONTAINING PROTEIN 2 cytokine#PC00083;interleukin superfamily#PC00128 HUMAN|HGNC=6827|UniProtKB=Q9NTJ4 Q9NTJ4 MAN2C1 PTHR46017:SF1 ALPHA-MANNOSIDASE 2C1 ALPHA-MANNOSIDASE 2C1 hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787 cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate metabolic process#GO:0005975;oligosaccharide catabolic process#GO:0009313;catabolic process#GO:0009056;metabolic process#GO:0008152;oligosaccharide metabolic process#GO:0009311;carbohydrate catabolic process#GO:0016052 HUMAN|HGNC=3182|UniProtKB=P78364 P78364 PHC1 PTHR12247:SF20 POLYCOMB GROUP PROTEIN POLYHOMEOTIC-LIKE PROTEIN 1 chromatin binding#GO:0003682;histone binding#GO:0042393;binding#GO:0005488;protein binding#GO:0005515 negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;nuclear ubiquitin ligase complex#GO:0000152;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ubiquitin ligase complex#GO:0000151;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;PcG protein complex#GO:0031519;nucleus#GO:0005634;protein-containing complex#GO:0032991;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;PRC1 complex#GO:0035102 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=4936|UniProtKB=P06340 P06340 HLA-DOA PTHR19944:SF44 MHC CLASS II-RELATED HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DO ALPHA CHAIN peptide binding#GO:0042277;antigen binding#GO:0003823;binding#GO:0005488;protein-containing complex binding#GO:0044877 antigen processing and presentation#GO:0019882;positive regulation of lymphocyte activation#GO:0051251;regulation of immune response#GO:0050776;regulation of cell-cell adhesion#GO:0022407;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;positive regulation of cell adhesion#GO:0045785;regulation of leukocyte cell-cell adhesion#GO:1903037;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;regulation of cell adhesion#GO:0030155;positive regulation of response to stimulus#GO:0048584;positive regulation of cell activation#GO:0050867;positive regulation of leukocyte cell-cell adhesion#GO:1903039;biological regulation#GO:0065007;positive regulation of cellular process#GO:0048522;immune system process#GO:0002376;regulation of lymphocyte activation#GO:0051249;cellular component organization#GO:0016043;regulation of leukocyte activation#GO:0002694;positive regulation of multicellular organismal process#GO:0051240;regulation of cell activation#GO:0050865;protein-containing complex assembly#GO:0065003;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;positive regulation of leukocyte activation#GO:0002696;regulation of T cell activation#GO:0050863;positive regulation of T cell activation#GO:0050870;cellular component assembly#GO:0022607;regulation of multicellular organismal process#GO:0051239;positive regulation of immune system process#GO:0002684;cellular component biogenesis#GO:0044085;positive regulation of cell-cell adhesion#GO:0022409;cellular process#GO:0009987;positive regulation of biological process#GO:0048518 intracellular organelle#GO:0043229;endosome#GO:0005768;endosome membrane#GO:0010008;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;lytic vacuole membrane#GO:0098852;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;vesicle#GO:0031982;plasma membrane protein complex#GO:0098797;lysosome#GO:0005764;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;late endosome membrane#GO:0031902;lytic vacuole#GO:0000323;vacuolar membrane#GO:0005774;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;vesicle membrane#GO:0012506;membrane#GO:0016020;lysosomal membrane#GO:0005765;cell periphery#GO:0071944;late endosome#GO:0005770;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;vacuole#GO:0005773;plasma membrane#GO:0005886;cytoplasm#GO:0005737 major histocompatibility complex protein#PC00149 T cell activation#P00053>MHC-antigen#P01316 HUMAN|HGNC=5181|UniProtKB=P04196 P04196 HRG PTHR13814:SF3 FETUIN HISTIDINE-RICH GLYCOPROTEIN cation binding#GO:0043169;transition metal ion binding#GO:0046914;peptidase regulator activity#GO:0061134;small molecule binding#GO:0036094;glycosaminoglycan binding#GO:0005539;ion binding#GO:0043167;endopeptidase regulator activity#GO:0061135;molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866;enzyme inhibitor activity#GO:0004857;heparin binding#GO:0008201;zinc ion binding#GO:0008270;molecular function inhibitor activity#GO:0140678;serine-type endopeptidase inhibitor activity#GO:0004867;metal ion binding#GO:0046872;enzyme regulator activity#GO:0030234;peptidase inhibitor activity#GO:0030414;binding#GO:0005488;carbohydrate derivative binding#GO:0097367 positive regulation of biological process#GO:0048518;defense response to symbiont#GO:0140546;regulation of response to wounding#GO:1903034;response to biotic stimulus#GO:0009607;positive regulation of immune system process#GO:0002684;response to stress#GO:0006950;regulation of multicellular organismal process#GO:0051239;regulation of response to external stimulus#GO:0032101;defense response to other organism#GO:0098542;humoral immune response#GO:0006959;antimicrobial humoral response#GO:0019730;positive regulation of response to external stimulus#GO:0032103;regulation of biological process#GO:0050789;positive regulation of multicellular organismal process#GO:0051240;regulation of cell activation#GO:0050865;negative regulation of biological process#GO:0048519;biological process involved in interspecies interaction between organisms#GO:0044419;regulation of wound healing#GO:0061041;response to stimulus#GO:0050896;regulation of blood coagulation#GO:0030193;regulation of body fluid levels#GO:0050878;immune system process#GO:0002376;positive regulation of coagulation#GO:0050820;regulation of biological quality#GO:0065008;immune response#GO:0006955;regulation of hemostasis#GO:1900046;biological regulation#GO:0065007;response to other organism#GO:0051707;regulation of coagulation#GO:0050818;positive regulation of response to stimulus#GO:0048584;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;regulation of response to stress#GO:0080134;response to external stimulus#GO:0009605;positive regulation of response to biotic stimulus#GO:0002833;defense response#GO:0006952;response to external biotic stimulus#GO:0043207;regulation of response to biotic stimulus#GO:0002831;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of immune response#GO:0050776;regulation of platelet activation#GO:0010543;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease inhibitor#PC00191 HUMAN|HGNC=7423|UniProtKB=P56278 P56278 MTCP1 PTHR14060:SF8 PROTEIN P13 MTCP-1 PROTEIN P13 MTCP-1 enzyme activator activity#GO:0008047;protein serine/threonine kinase activator activity#GO:0043539;protein kinase activator activity#GO:0030295;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;protein kinase regulator activity#GO:0019887;kinase activator activity#GO:0019209;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 HUMAN|HGNC=1736|UniProtKB=P60953 P60953 CDC42 PTHR24072:SF136 RHO FAMILY GTPASE CELL DIVISION CONTROL PROTEIN 42 HOMOLOG nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;GTPase activity#GO:0003924;ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;protein binding#GO:0005515;protein kinase binding#GO:0019901;guanyl nucleotide binding#GO:0019001;enzyme binding#GO:0019899;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;kinase binding#GO:0019900;binding#GO:0005488 actin filament organization#GO:0007015;regulation of filopodium assembly#GO:0051489;establishment of localization#GO:0051234;import into cell#GO:0098657;regulation of plasma membrane bounded cell projection organization#GO:0120035;cellular component organization or biogenesis#GO:0071840;transport#GO:0006810;regulation of cell projection organization#GO:0031344;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;organelle organization#GO:0006996;regulation of cell projection assembly#GO:0060491;supramolecular fiber organization#GO:0097435;localization#GO:0051179;cell communication#GO:0007154;actin filament-based process#GO:0030029;establishment or maintenance of cell polarity#GO:0007163;regulation of cellular component biogenesis#GO:0044087;signaling#GO:0023052;actin cytoskeleton organization#GO:0030036;endocytosis#GO:0006897;regulation of cellular process#GO:0050794;regulation of plasma membrane bounded cell projection assembly#GO:0120032;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;establishment of cell polarity#GO:0030010;regulation of biological process#GO:0050789;cellular component organization#GO:0016043 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 small GTPase#PC00208;G-protein#PC00020 Integrin signalling pathway#P00034>Cdc42#P00938;Gonadotropin-releasing hormone receptor pathway#P06664>Cdc42#P06743;CCKR signaling map#P06959>CDC42-GDP#P07044;Ras Pathway#P04393>Cdc42#P04569;Cytoskeletal regulation by Rho GTPase#P00016>Cdc42#P00515;CCKR signaling map#P06959>CDC42-GTP#P07155;T cell activation#P00053>cdc42#P01333;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Cdc42#P00834;Huntington disease#P00029>Rac#P00775;Axon guidance mediated by Slit/Robo#P00008>Cdc42#P00349;p38 MAPK pathway#P05918>Cdc42#P06041;Axon guidance mediated by netrin#P00009>cdc42#P00364 HUMAN|HGNC=26457|UniProtKB=Q96N22 Q96N22 ZNF681 PTHR24377:SF356 IP01015P-RELATED ZINC FINGER PROTEIN 681 RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=1383|UniProtKB=Q16790 Q16790 CA9 PTHR18952:SF18 CARBONIC ANHYDRASE CARBONIC ANHYDRASE 9 catalytic activity#GO:0003824;carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;hydro-lyase activity#GO:0016836 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 dehydratase#PC00091;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=29248|UniProtKB=Q86T90 Q86T90 KIAA1328 PTHR28375:SF1 PROTEIN HINDERIN PROTEIN HINDERIN HUMAN|HGNC=37267|UniProtKB=P0CJ85 P0CJ85 DUX4L2 PTHR46123:SF3 MIX-TYPE HOMEOBOX GENE 1-RELATED DOUBLE HOMEOBOX PROTEIN 1-RELATED sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=15466|UniProtKB=Q9HC57 Q9HC57 WFDC1 PTHR14308:SF0 WAP FOUR-DISULFIDE CORE DOMAIN PROTEIN 1 WAP FOUR-DISULFIDE CORE DOMAIN PROTEIN 1 biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of cell growth#GO:0001558;regulation of cellular component organization#GO:0051128;regulation of biological process#GO:0050789;regulation of growth#GO:0040008 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=18597|UniProtKB=P59817 P59817 ZNF280A PTHR24388:SF47 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 280A cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=6836|UniProtKB=P46821 P46821 MAP1B PTHR13843:SF5 MICROTUBULE-ASSOCIATED PROTEIN MICROTUBULE-ASSOCIATED PROTEIN 1B protein binding#GO:0005515;microtubule binding#GO:0008017;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;tubulin binding#GO:0015631 cellular process#GO:0009987;regulation of protein-containing complex disassembly#GO:0043244;neuron projection development#GO:0031175;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;nervous system development#GO:0007399;regulation of microtubule cytoskeleton organization#GO:0070507;cell morphogenesis involved in neuron differentiation#GO:0048667;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell projection morphogenesis#GO:0048858;microtubule-based process#GO:0007017;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;regulation of organelle organization#GO:0033043;cellular component organization#GO:0016043;cell development#GO:0048468;regulation of cellular component organization#GO:0051128;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell morphogenesis#GO:0000902;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;neuron development#GO:0048666;axonogenesis#GO:0007409;dendrite development#GO:0016358;axon development#GO:0061564;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;multicellular organismal process#GO:0032501;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;neurogenesis#GO:0022008;regulation of microtubule polymerization or depolymerization#GO:0031110;regulation of protein depolymerization#GO:1901879;cellular developmental process#GO:0048869;regulation of supramolecular fiber organization#GO:1902903;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794;regulation of microtubule-based process#GO:0032886;system development#GO:0048731;anatomical structure development#GO:0048856;microtubule cytoskeleton organization#GO:0000226 cell body#GO:0044297;cell projection#GO:0042995;neuronal cell body#GO:0043025;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;synapse#GO:0045202;intracellular organelle#GO:0043229;dendritic tree#GO:0097447;dendrite#GO:0030425;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;neuron projection#GO:0043005;cytosol#GO:0005829;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;somatodendritic compartment#GO:0036477;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;microtubule associated complex#GO:0005875;cytoskeleton#GO:0005856;cell junction#GO:0030054;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=3318|UniProtKB=P78545 P78545 ELF3 PTHR11849:SF13 ETS ETS-RELATED TRANSCRIPTION FACTOR ELF-3 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;developmental process#GO:0032502;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;winged helix/forkhead transcription factor#PC00246 PDGF signaling pathway#P00047>Ets#P01167 HUMAN|HGNC=6302|UniProtKB=Q9BQ31 Q9BQ31 KCNS3 PTHR11537:SF39 VOLTAGE-GATED POTASSIUM CHANNEL DELAYED-RECTIFIER POTASSIUM CHANNEL REGULATORY SUBUNIT KCNS3 transporter regulator activity#GO:0141108;potassium channel regulator activity#GO:0015459;ion channel regulator activity#GO:0099106;channel regulator activity#GO:0016247;molecular function regulator activity#GO:0098772 regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;transport#GO:0006810;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;biological regulation#GO:0065007;potassium ion transport#GO:0006813;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;metal ion transport#GO:0030001;action potential#GO:0001508 transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;cation channel complex#GO:0034703;voltage-gated potassium channel complex#GO:0008076;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane protein complex#GO:0098796;membrane#GO:0016020 voltage-gated ion channel#PC00241;ion channel#PC00133 HUMAN|HGNC=12475|UniProtKB=P62837 P62837 UBE2D2 PTHR24068:SF330 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2 D2 aminoacyltransferase activity#GO:0016755;ubiquitin conjugating enzyme activity#GO:0061631;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-like protein conjugating enzyme activity#GO:0061650;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746 catabolic process#GO:0009056;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;protein polyubiquitination#GO:0000209;primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein modification by small protein conjugation or removal#GO:0070647;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;cellular process#GO:0009987;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein K48-linked ubiquitination#GO:0070936;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057 ubiquitin-protein ligase#PC00234 Ubiquitin proteasome pathway#P00060>E2#P01491 HUMAN|HGNC=12754|UniProtKB=O75083 O75083 WDR1 PTHR19856:SF8 WD-REPEATCONTAINING PROTEIN WDR1 WD REPEAT-CONTAINING PROTEIN 1 actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;actin filament binding#GO:0051015;binding#GO:0005488;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 actin filament organization#GO:0007015;cellular developmental process#GO:0048869;developmental process#GO:0032502;protein depolymerization#GO:0051261;actin polymerization or depolymerization#GO:0008154;supramolecular fiber organization#GO:0097435;anatomical structure development#GO:0048856;actin filament-based process#GO:0030029;sarcomere organization#GO:0045214;cellular component assembly involved in morphogenesis#GO:0010927;organelle assembly#GO:0070925;protein-containing complex disassembly#GO:0032984;muscle structure development#GO:0061061;actin cytoskeleton organization#GO:0030036;muscle cell differentiation#GO:0042692;myofibril assembly#GO:0030239;muscle cell development#GO:0055001;anatomical structure formation involved in morphogenesis#GO:0048646;protein-containing complex organization#GO:0043933;striated muscle cell differentiation#GO:0051146;cellular component organization or biogenesis#GO:0071840;cellular anatomical entity morphogenesis#GO:0032989;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;cellular process#GO:0009987;actin filament depolymerization#GO:0030042;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular component disassembly#GO:0022411;striated muscle cell development#GO:0055002;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;actomyosin structure organization#GO:0031032;cell differentiation#GO:0030154;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;cortical actin cytoskeleton#GO:0030864;intracellular membraneless organelle#GO:0043232;cortical cytoskeleton#GO:0030863;actin cytoskeleton#GO:0015629;cell periphery#GO:0071944;cell cortex#GO:0005938;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 non-motor actin binding protein#PC00165;actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=43880|UniProtKB=A0A0U1RRI6 A0A0U1RRI6 CENPVL3 PTHR28620:SF7 CENTROMERE PROTEIN V CENTROMERE PROTEIN V-LIKE PROTEIN 3 HUMAN|HGNC=6087|UniProtKB=Q14641 Q14641 INSL4 PTHR12004:SF3 RELAXIN EARLY PLACENTA INSULIN-LIKE PEPTIDE intercellular signal molecule#PC00207;peptide hormone#PC00179 HUMAN|HGNC=51510|UniProtKB=P0DUD3 P0DUD3 SPDYE14 PTHR31156:SF15 WBSCR19-LIKE PROTEIN SPEEDY PROTEIN E10-RELATED HUMAN|HGNC=22301|UniProtKB=Q7Z7H5 Q7Z7H5 TMED4 PTHR22811:SF38 TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN 4 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;cargo adaptor activity#GO:0140312 cellular localization#GO:0051641;localization#GO:0051179;protein transport#GO:0015031;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular component organization#GO:0016043;Golgi organization#GO:0007030;intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;transport#GO:0006810;intracellular protein transport#GO:0006886;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;intracellular protein localization#GO:0008104;organelle organization#GO:0006996;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;vesicle-mediated transport#GO:0016192;endomembrane system organization#GO:0010256 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;coated vesicle#GO:0030135;cytoplasmic vesicle#GO:0031410;COPII-coated ER to Golgi transport vesicle#GO:0030134;vesicle#GO:0031982;intracellular vesicle#GO:0097708;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endoplasmic reticulum#GO:0005783;Golgi apparatus#GO:0005794;cytoplasm#GO:0005737;endomembrane system#GO:0012505 vesicle coat protein#PC00235;membrane traffic protein#PC00150 HUMAN|HGNC=2396|UniProtKB=P53673 P53673 CRYBA4 PTHR11818:SF19 BETA/GAMMA CRYSTALLIN BETA-CRYSTALLIN A4 structural molecule activity#GO:0005198 visual perception#GO:0007601;visual system development#GO:0150063;sensory perception of light stimulus#GO:0050953;anatomical structure development#GO:0048856;system development#GO:0048731;eye development#GO:0001654;camera-type eye development#GO:0043010;animal gross anatomical part developmental process#GO:0160108;sensory perception#GO:0007600;nervous system process#GO:0050877;multicellular organismal process#GO:0032501;sensory system development#GO:0048880;multicellular organism development#GO:0007275;animal organ development#GO:0048513;system process#GO:0003008;sensory organ development#GO:0007423;developmental process#GO:0032502;lens development in camera-type eye#GO:0002088 structural protein#PC00211 HUMAN|HGNC=9504|UniProtKB=O43739 O43739 CYTH3 PTHR10663:SF320 GUANYL-NUCLEOTIDE EXCHANGE FACTOR CYTOHESIN-3 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=26213|UniProtKB=Q9H628 Q9H628 RERGL PTHR45704:SF9 RAS-LIKE FAMILY MEMBER 11 RAS-RELATED AND ESTROGEN-REGULATED GROWTH INHIBITOR-LIKE PROTEIN HUMAN|HGNC=25821|UniProtKB=Q96K58 Q96K58 ZNF668 PTHR24376:SF70 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 668 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=4471|UniProtKB=Q13304 Q13304 GPR17 PTHR24232:SF44 G-PROTEIN COUPLED RECEPTOR URACIL NUCLEOTIDE_CYSTEINYL LEUKOTRIENE RECEPTOR G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=11540|UniProtKB=P49848 P49848 TAF6 PTHR10221:SF9 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6 protein complex scaffold activity#GO:0140378;structural molecule activity#GO:0005198 gene expression#GO:0010467;cellular component assembly#GO:0022607;protein-DNA complex assembly#GO:0065004;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;cellular component biogenesis#GO:0044085;transcription initiation at RNA polymerase II promoter#GO:0006367;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component organization or biogenesis#GO:0071840;protein-DNA complex organization#GO:0071824;macromolecule metabolic process#GO:0043170;protein-containing complex organization#GO:0043933;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;transcription by RNA polymerase II#GO:0006366;DNA-templated transcription initiation#GO:0006352;RNA polymerase II preinitiation complex assembly#GO:0051123;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;protein-containing complex assembly#GO:0065003;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187 transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;transcription regulator complex#GO:0005667;intracellular protein-containing complex#GO:0140535;membrane-enclosed lumen#GO:0031974;RNA polymerase II transcription regulator complex#GO:0090575;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;protein-containing complex#GO:0032991;transcription factor TFIID complex#GO:0005669;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;RNA polymerase II, holoenzyme#GO:0016591;membrane-bounded organelle#GO:0043227;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 general transcription factor#PC00259 Transcription regulation by bZIP transcription factor#P00055>TBP-associated factors#P01385;General transcription regulation#P00023>TBP#P00670;General transcription regulation#P00023>TBP-associated factors#P00658 HUMAN|HGNC=43624|UniProtKB=A0A1W2PQ64 A0A1W2PQ64 SSU72L5 PTHR20383:SF10 RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE SSU72 LIKE PROTEIN 1-RELATED phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721;protein serine/threonine phosphatase activity#GO:0004722 biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;DNA-templated transcription termination#GO:0006353;mRNA processing#GO:0006397;RNA 3'-end processing#GO:0031123;macromolecule metabolic process#GO:0043170;transcription by RNA polymerase II#GO:0006366;nucleobase-containing compound biosynthetic process#GO:0034654;termination of RNA polymerase II transcription#GO:0006369;mRNA 3'-end processing#GO:0031124;metabolic process#GO:0008152;DNA-templated transcription#GO:0006351;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187 intracellular organelle#GO:0043229;mRNA cleavage and polyadenylation specificity factor complex#GO:0005847;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;mRNA cleavage factor complex#GO:0005849;organelle#GO:0043226 protein phosphatase#PC00195 HUMAN|HGNC=37270|UniProtKB=C9JQI7 C9JQI7 TMEM232 PTHR28651:SF2 TRANSMEMBRANE PROTEIN 232 TRANSMEMBRANE PROTEIN 232 flagellated sperm motility#GO:0030317;developmental process#GO:0032502;spermatogenesis#GO:0007283;microtubule-based process#GO:0007017;cilium movement involved in cell motility#GO:0060294;cellular process#GO:0009987;male gamete generation#GO:0048232;sexual reproduction#GO:0019953;cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;cilium-dependent cell motility#GO:0060285;multicellular organismal reproductive process#GO:0048609;developmental process involved in reproduction#GO:0003006;sperm motility#GO:0097722;microtubule-based movement#GO:0007018;cell motility#GO:0048870;gamete generation#GO:0007276;reproductive process#GO:0022414 membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;sperm flagellum#GO:0036126;supramolecular fiber#GO:0099512;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cilium#GO:0005929;intracellular organelle#GO:0043229;9+2 motile cilium#GO:0097729;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;motile cilium#GO:0031514;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=30633|UniProtKB=Q96IW2 Q96IW2 SHD PTHR15127:SF33 HEAVYWEIGHT, ISOFORM A SH2 DOMAIN-CONTAINING ADAPTER PROTEIN D binding#GO:0005488;protein binding#GO:0005515 HUMAN|Ensembl=ENSG00000283716.3|UniProtKB=A0A5F9Z9Y6 A0A5F9Z9Y6 PTHR11738:SF168 MHC CLASS I NK CELL RECEPTOR IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN-RELATED transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;immune receptor activity#GO:0140375;signaling receptor activity#GO:0038023 cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;regulation of response to stimulus#GO:0048583;regulation of immune response#GO:0050776;signaling#GO:0023052;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;immune response-regulating signaling pathway#GO:0002764;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=9757|UniProtKB=Q15032 Q15032 R3HDM1 PTHR15672:SF12 CAMP-REGULATED PHOSPHOPROTEIN 21 RELATED R3H DOMAIN CONTAINING PROTEIN R3H DOMAIN-CONTAINING PROTEIN 1 HUMAN|HGNC=9535|UniProtKB=P60900 P60900 PSMA6 PTHR11599:SF247 PROTEASOME SUBUNIT ALPHA/BETA PROTEASOME SUBUNIT ALPHA TYPE-6 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;endopeptidase complex#GO:1905369;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;proteasome complex#GO:0000502;nucleus#GO:0005634;peptidase complex#GO:1905368;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 protease#PC00190;protein modifying enzyme#PC00260 Parkinson disease#P00049>20S proteasome#P01227 HUMAN|HGNC=26961|UniProtKB=Q8NCN4 Q8NCN4 RNF169 PTHR23328:SF2 RING-TYPE DOMAIN-CONTAINING PROTEIN E3 UBIQUITIN-PROTEIN LIGASE RNF169 binding#GO:0005488;acyltransferase activity#GO:0016746;chromatin binding#GO:0003682;ubiquitin-like protein transferase activity#GO:0019787;protein-containing complex binding#GO:0044877;ubiquitin-protein transferase activity#GO:0004842;nucleosome binding#GO:0031491;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;response to stress#GO:0006950;nucleobase-containing compound metabolic process#GO:0006139;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694;site of double-strand break#GO:0035861;nucleus#GO:0005634;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;site of DNA damage#GO:0090734;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HUMAN|HGNC=259|UniProtKB=P35318 P35318 ADM PTHR23414:SF3 ADRENOMEDULLIN, ADM PRO-ADRENOMEDULLIN receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;G protein-coupled receptor binding#GO:0001664;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515;molecular function activator activity#GO:0140677;hormone activity#GO:0005179 circulatory system process#GO:0003013;G protein-coupled receptor signaling pathway#GO:0007186;regulation of biological quality#GO:0065008;cell communication#GO:0007154;positive regulation of multicellular organismal process#GO:0051240;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of heart contraction#GO:0008016;signaling#GO:0023052;regulation of body fluid levels#GO:0050878;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;regulation of system process#GO:0044057;system process#GO:0003008;cellular process#GO:0009987;renal system process#GO:0003014;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;regulation of systemic arterial blood pressure#GO:0003073;regulation of blood pressure#GO:0008217;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;blood circulation#GO:0008015 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 peptide hormone#PC00179;intercellular signal molecule#PC00207 HUMAN|HGNC=6679|UniProtKB=Q93052 Q93052 LPP PTHR24207:SF0 ZYX102 PROTEIN LIPOMA-PREFERRED PARTNER cellular process#GO:0009987;cell adhesion#GO:0007155;cell-cell adhesion#GO:0098609 stress fiber#GO:0001725;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;cell junction#GO:0030054;actin filament bundle#GO:0032432;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;actin cytoskeleton#GO:0015629;actomyosin#GO:0042641;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell-substrate junction#GO:0030055;intracellular membraneless organelle#GO:0043232;focal adhesion#GO:0005925 kinase modulator#PC00140 HUMAN|HGNC=10839|UniProtKB=P04278 P04278 SHBG PTHR24040:SF3 LAMININ G-LIKE DOMAIN-CONTAINING PROTEIN SEX HORMONE-BINDING GLOBULIN lipid binding#GO:0008289;steroid binding#GO:0005496;hormone binding#GO:0042562;binding#GO:0005488 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=18644|UniProtKB=Q9P2G9 Q9P2G9 KLHL8 PTHR24412:SF480 KELCH PROTEIN KELCH-LIKE PROTEIN 8 ubiquitin-like ligase-substrate adaptor activity#GO:1990756;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;enzyme-substrate adaptor activity#GO:0140767 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;Cul3-RING ubiquitin ligase complex#GO:0031463;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;transferase complex#GO:1990234;cullin-RING ubiquitin ligase complex#GO:0031461;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 scaffold/adaptor protein#PC00226 HUMAN|HGNC=9341|UniProtKB=O43663 O43663 PRC1 PTHR19321:SF1 PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED PROTEIN REGULATOR OF CYTOKINESIS 1 cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;microtubule binding#GO:0008017;binding#GO:0005488;protein binding#GO:0005515 chromosome segregation#GO:0007059;cellular component organization or biogenesis#GO:0071840;spindle organization#GO:0007051;chromosome organization#GO:0051276;microtubule-based process#GO:0007017;mitotic cell cycle process#GO:1903047;spindle assembly#GO:0051225;mitotic sister chromatid segregation#GO:0000070;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;mitotic spindle assembly#GO:0090307;cellular component assembly#GO:0022607;spindle elongation#GO:0051231;cytoskeleton organization#GO:0007010;nuclear division#GO:0000280;organelle assembly#GO:0070925;microtubule cytoskeleton organization#GO:0000226;organelle fission#GO:0048285;membraneless organelle assembly#GO:0140694;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cellular component organization#GO:0016043;sister chromatid segregation#GO:0000819;nuclear chromosome segregation#GO:0098813;cell cycle#GO:0007049;mitotic nuclear division#GO:0140014;cell cycle process#GO:0022402;mitotic spindle organization#GO:0007052;mitotic cell cycle#GO:0000278 cytoskeleton#GO:0005856;spindle#GO:0005819;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;spindle midzone#GO:0051233;microtubule cytoskeleton#GO:0015630;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;mitotic spindle#GO:0072686 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HUMAN|HGNC=534|UniProtKB=Q9UJ72 Q9UJ72 ANXA10 PTHR10502:SF100 ANNEXIN ANNEXIN A10 small molecule binding#GO:0036094;phospholipid binding#GO:0005543;anion binding#GO:0043168;binding#GO:0005488;ion binding#GO:0043167;lipid binding#GO:0008289;phosphatidylserine binding#GO:0001786 membrane#GO:0016020;vesicle membrane#GO:0012506;nucleus#GO:0005634;cell periphery#GO:0071944;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;plasma membrane#GO:0005886;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227 calcium-binding protein#PC00060 HUMAN|HGNC=27010|UniProtKB=Q17R31 Q17R31 TATDN3 PTHR46317:SF7 HYDROLASE OF PHP SUPERFAMILY-RELATED PROTEIN DEOXYRIBONUCLEASE TATDN3 hydrolase#PC00121 HUMAN|HGNC=4929|UniProtKB=P10073 P10073 ZSCAN22 PTHR23226:SF59 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 22 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=6171|UniProtKB=Q08881 Q08881 ITK PTHR24418:SF61 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE ITK_TSK non-membrane spanning protein tyrosine kinase activity#GO:0004715;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096 developmental process#GO:0032502;cellular developmental process#GO:0048869;cellular process#GO:0009987;multicellular organismal process#GO:0032501;lymphocyte activation#GO:0046649;hemopoiesis#GO:0030097;T cell differentiation#GO:0030217;immune system process#GO:0002376;cell activation#GO:0001775;lymphocyte differentiation#GO:0030098;anatomical structure development#GO:0048856;T cell activation#GO:0042110;leukocyte differentiation#GO:0002521;leukocyte activation#GO:0045321;mononuclear cell differentiation#GO:1903131;cell differentiation#GO:0030154;cell development#GO:0048468 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 non-receptor tyrosine protein kinase#PC00168 HUMAN|HGNC=16782|UniProtKB=Q7Z2T5 Q7Z2T5 TRMT1L PTHR10631:SF1 N 2 ,N 2 -DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE TRNA (GUANINE(27)-N(2))-DIMETHYLTRANSFERASE N-methyltransferase activity#GO:0008170;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;tRNA (guanine) methyltransferase activity#GO:0016423;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on RNA#GO:0140098;RNA methyltransferase activity#GO:0008173;tRNA methyltransferase activity#GO:0008175 gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 RNA methyltransferase#PC00033;RNA metabolism protein#PC00031 HUMAN|HGNC=20040|UniProtKB=Q01518 Q01518 CAP1 PTHR10652:SF1 ADENYLYL CYCLASE-ASSOCIATED PROTEIN ADENYLYL CYCLASE-ASSOCIATED PROTEIN 1 enzyme binding#GO:0019899;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;protein binding#GO:0005515 cellular process#GO:0009987;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;cell morphogenesis#GO:0000902;actin cytoskeleton organization#GO:0030036;actin filament-based process#GO:0030029;developmental process#GO:0032502;actin filament organization#GO:0007015;supramolecular fiber organization#GO:0097435;anatomical structure development#GO:0048856;cellular component organization or biogenesis#GO:0071840 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 actin or actin-binding cytoskeletal protein#PC00041;cytoskeletal protein#PC00085 HUMAN|HGNC=26505|UniProtKB=Q3MIT2 Q3MIT2 PUS10 PTHR21568:SF0 TRNA PSEUDOURIDINE SYNTHASE PUS10 TRNA PSEUDOURIDINE SYNTHASE PUS10 catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;intramolecular transferase activity#GO:0016866;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098;isomerase activity#GO:0016853 negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;negative regulation of metabolic process#GO:0009892;tRNA modification#GO:0006400;nucleic acid biosynthetic process#GO:0141187;miRNA processing#GO:0035196;RNA modification#GO:0009451;RNA metabolic process#GO:0016070;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;gene expression#GO:0010467;RNA processing#GO:0006396;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA processing#GO:0008033;primary miRNA processing#GO:0031053;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;pseudouridine synthesis#GO:0001522;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;RNA biosynthetic process#GO:0032774;macromolecule modification#GO:0043412;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;macromolecule biosynthetic process#GO:0009059;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;negative regulation of biosynthetic process#GO:0009890;negative regulation of cellular process#GO:0048523;regulatory ncRNA-mediated gene silencing#GO:0031047;macromolecule metabolic process#GO:0043170;regulatory ncRNA processing#GO:0070918;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=18187|UniProtKB=Q9HAT2 Q9HAT2 SIAE PTHR22901:SF0 SIALATE O-ACETYLESTERASE SIALATE O-ACETYLESTERASE hydrolase activity, acting on ester bonds#GO:0016788;carboxylic ester hydrolase activity#GO:0052689;catalytic activity#GO:0003824;hydrolase activity#GO:0016787 primary metabolic process#GO:0044238;metabolic process#GO:0008152;cellular process#GO:0009987;carbohydrate metabolic process#GO:0005975 hydrolase#PC00121;esterase#PC00097 HUMAN|HGNC=25678|UniProtKB=Q9HAE3 Q9HAE3 CLXN PTHR23055:SF75 CALCIUM BINDING PROTEINS CALAXIN cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 calmodulin-related#PC00061 HUMAN|HGNC=20192|UniProtKB=Q9H0R1 Q9H0R1 AP5M1 PTHR16082:SF2 AP-5 COMPLEX SUBUNIT MU-1 AP-5 COMPLEX SUBUNIT MU-1 establishment of localization in cell#GO:0051649;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;transport#GO:0006810;intracellular transport#GO:0046907;endosomal transport#GO:0016197;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234 vesicle#GO:0031982;lysosome#GO:0005764;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;coated membrane#GO:0048475;membrane coat#GO:0030117;cytosol#GO:0005829;membrane#GO:0016020;vacuole#GO:0005773;cytoplasm#GO:0005737;late endosome#GO:0005770;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;AP-type membrane coat adaptor complex#GO:0030119;lytic vacuole#GO:0000323 HUMAN|HGNC=10700|UniProtKB=O75396 O75396 SEC22B PTHR45837:SF3 VESICLE-TRAFFICKING PROTEIN SEC22B VESICLE-TRAFFICKING PROTEIN SEC22B molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;SNAP receptor activity#GO:0005484 organelle organization#GO:0006996;membrane fusion#GO:0061025;establishment of localization in cell#GO:0051649;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;cellular process#GO:0009987;organelle fusion#GO:0048284;vesicle-mediated transport#GO:0016192;membrane organization#GO:0061024;endomembrane system organization#GO:0010256;organelle membrane fusion#GO:0090174;intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;transport#GO:0006810;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;vesicle organization#GO:0016050;cellular component organization#GO:0016043;Golgi organization#GO:0007030;vesicle fusion#GO:0006906;localization#GO:0051179;cellular localization#GO:0051641;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888 organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;coated vesicle membrane#GO:0030662;intracellular vesicle#GO:0097708;organelle subcompartment#GO:0031984;coated vesicle#GO:0030135;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;bounding membrane of organelle#GO:0098588;Golgi membrane#GO:0000139;endoplasmic reticulum#GO:0005783;SNARE complex#GO:0031201;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;vesicle#GO:0031982;COPII-coated ER to Golgi transport vesicle#GO:0030134;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;endoplasmic reticulum subcompartment#GO:0098827;transport vesicle#GO:0030133;transport vesicle membrane#GO:0030658;endomembrane system#GO:0012505;vesicle membrane#GO:0012506;membrane#GO:0016020;organelle membrane#GO:0031090;Golgi apparatus#GO:0005794;endoplasmic reticulum membrane#GO:0005789;ER to Golgi transport vesicle membrane#GO:0012507 HUMAN|HGNC=33823|UniProtKB=P60508 P60508 ERVFRD-1 PTHR10424:SF85 VIRAL ENVELOPE PROTEIN SYNCYTIN-2 myoblast fusion#GO:0007520;muscle cell differentiation#GO:0042692;cellular process#GO:0009987;cell differentiation#GO:0030154;muscle structure development#GO:0061061;cell-cell fusion#GO:0140253;animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502;syncytium formation by cell-cell fusion#GO:0000768;anatomical structure development#GO:0048856;cellular developmental process#GO:0048869;striated muscle cell differentiation#GO:0051146 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 viral or transposable element protein#PC00237 HUMAN|HGNC=20758|UniProtKB=Q96K21 Q96K21 ZFYVE19 PTHR46603:SF1 ABSCISSION/NOCUT CHECKPOINT REGULATOR ABSCISSION_NOCUT CHECKPOINT REGULATOR phosphatidylinositol phosphate binding#GO:1901981;lipid binding#GO:0008289;phosphatidylinositol-3-phosphate binding#GO:0032266;binding#GO:0005488;phospholipid binding#GO:0005543 cellular process#GO:0009987;signal transduction#GO:0007165;regulation of cell cycle process#GO:0010564;negative regulation of G2/M transition of mitotic cell cycle#GO:0010972;negative regulation of mitotic cell cycle phase transition#GO:1901991;cell cycle checkpoint signaling#GO:0000075;negative regulation of cell cycle G2/M phase transition#GO:1902750;negative regulation of cell cycle#GO:0045786;cell cycle process#GO:0022402;regulation of biological process#GO:0050789;negative regulation of cell cycle phase transition#GO:1901988;negative regulation of biological process#GO:0048519;signaling#GO:0023052;regulation of cell cycle#GO:0051726;response to stimulus#GO:0050896;negative regulation of mitotic cell cycle#GO:0045930;regulation of mitotic cell cycle phase transition#GO:1901990;regulation of mitotic cell cycle#GO:0007346;regulation of cell cycle G2/M phase transition#GO:1902749;biological regulation#GO:0065007;negative regulation of cell cycle process#GO:0010948;negative regulation of cellular process#GO:0048523;mitotic cell cycle process#GO:1903047;cellular response to stimulus#GO:0051716;cell cycle#GO:0007049;mitotic cell cycle checkpoint signaling#GO:0007093;regulation of cell cycle phase transition#GO:1901987;regulation of cellular process#GO:0050794;mitotic cell cycle#GO:0000278;intracellular signal transduction#GO:0035556;regulation of G2/M transition of mitotic cell cycle#GO:0010389;cell communication#GO:0007154 intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;midbody#GO:0030496;membraneless organelle#GO:0043228;cleavage furrow#GO:0032154;cytoskeleton#GO:0005856;centrosome#GO:0005813;microtubule organizing center#GO:0005815;plasma membrane region#GO:0098590;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;cell division site#GO:0032153;membrane#GO:0016020;microtubule cytoskeleton#GO:0015630;cell periphery#GO:0071944 HUMAN|HGNC=25319|UniProtKB=Q9H0C2 Q9H0C2 SLC25A31 PTHR45635:SF40 ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED ADP_ATP TRANSLOCASE 4 nucleobase-containing compound transmembrane transporter activity#GO:0015932;organophosphate ester transmembrane transporter activity#GO:0015605;carbohydrate derivative transmembrane transporter activity#GO:1901505;antiporter activity#GO:0015297;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;purine nucleotide transmembrane transporter activity#GO:0015216;active transmembrane transporter activity#GO:0022804 transport#GO:0006810;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;regulation of biological quality#GO:0065008;nitrogen compound transport#GO:0071705;cellular process#GO:0009987;carbohydrate derivative transport#GO:1901264;organophosphate ester transport#GO:0015748;regulation of membrane permeability#GO:0090559;nucleobase-containing compound transport#GO:0015931;biological regulation#GO:0065007;regulation of mitochondrial membrane permeability#GO:0046902 organelle membrane#GO:0031090;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrial membrane#GO:0031966;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;organelle envelope#GO:0031967;membrane protein complex#GO:0098796 transfer/carrier protein#PC00219 HUMAN|HGNC=26264|UniProtKB=Q8IWF2 Q8IWF2 FOXRED2 PTHR43539:SF23 FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220) FAD-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 2 nucleotide binding#GO:0000166;heterocyclic compound binding#GO:1901363;oxidoreductase activity#GO:0016491;monooxygenase activity#GO:0004497;catalytic activity#GO:0003824;ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265;anion binding#GO:0043168;small molecule binding#GO:0036094;flavin adenine dinucleotide binding#GO:0050660;binding#GO:0005488 proteasomal protein catabolic process#GO:0010498;response to chemical#GO:0042221;cellular process#GO:0009987;response to stress#GO:0006950;macromolecule metabolic process#GO:0043170;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;catabolic process#GO:0009056;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;ERAD pathway#GO:0036503;protein metabolic process#GO:0019538;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;response to endoplasmic reticulum stress#GO:0034976 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;endoplasmic reticulum lumen#GO:0005788;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 oxygenase#PC00177;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=7961|UniProtKB=Q15466 Q15466 NR0B2 PTHR24081:SF0 NUCLEAR RECEPTOR SUBFAMILY 0 GROUP B NUCLEAR RECEPTOR SUBFAMILY 0 GROUP B MEMBER 2 binding#GO:0005488;transcription regulator activity#GO:0140110;RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629;protein binding#GO:0005515;DNA-binding transcription factor binding#GO:0140297;transcription factor binding#GO:0008134;nuclear receptor binding#GO:0016922;transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712 negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;rhythmic process#GO:0048511;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;circadian rhythm#GO:0007623;negative regulation of biological process#GO:0048519;circadian regulation of gene expression#GO:0032922;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;C4 zinc finger nuclear receptor#PC00169 HUMAN|HGNC=23151|UniProtKB=Q86UX7 Q86UX7 FERMT3 PTHR16160:SF1 FERMITIN 2-RELATED FERMITIN FAMILY HOMOLOG 3 protein binding#GO:0005515;protein-containing complex binding#GO:0044877;integrin binding#GO:0005178;signaling receptor binding#GO:0005102;binding#GO:0005488;cell adhesion molecule binding#GO:0050839 cellular component assembly#GO:0022607;leukocyte cell-cell adhesion#GO:0007159;coagulation#GO:0050817;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;cell-cell adhesion#GO:0098609;response to stress#GO:0006950;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;platelet aggregation#GO:0070527;response to stimulus#GO:0050896;regulation of body fluid levels#GO:0050878;regulation of biological process#GO:0050789;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;wound healing#GO:0042060;regulation of biological quality#GO:0065008;cell adhesion#GO:0007155;cell-matrix adhesion#GO:0007160;biological regulation#GO:0065007;homotypic cell-cell adhesion#GO:0034109;regulation of cell adhesion#GO:0030155;multicellular organismal process#GO:0032501;response to wounding#GO:0009611;blood coagulation#GO:0007596;platelet activation#GO:0030168;regulation of cell adhesion mediated by integrin#GO:0033628;regulation of cell-cell adhesion#GO:0022407;regulation of cellular process#GO:0050794;hemostasis#GO:0007599;cell-substrate adhesion#GO:0031589;cell activation#GO:0001775 cell-substrate junction#GO:0030055;anchoring junction#GO:0070161;cell junction#GO:0030054;cellular anatomical structure#GO:0110165 HUMAN|HGNC=3280|UniProtKB=P55884 P55884 EIF3B PTHR14068:SF0 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 EIF3 -RELATED EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT B translation initiation factor activity#GO:0003743;translation factor activity#GO:0180051 primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;biosynthetic process#GO:0009058;metabolic process#GO:0008152;translation#GO:0006412;translational initiation#GO:0006413;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 eukaryotic translation initiation factor 3 complex#GO:0005852;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 translation initiation factor#PC00224 HUMAN|HGNC=28352|UniProtKB=Q9H467 Q9H467 CUEDC2 PTHR12493:SF0 CUE DOMAIN CONTAINING 2 CUE DOMAIN-CONTAINING PROTEIN 2 HUMAN|HGNC=1174|UniProtKB=Q96F05 Q96F05 C11orf24 PTHR16021:SF9 MANSC DOMAIN CONTAINING PROTEIN 1 PROSTATE ANDROGEN-REGULATED MUCIN-LIKE PROTEIN 1 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=29515|UniProtKB=Q9H7P9 Q9H7P9 PLEKHG2 PTHR45924:SF3 FI17866P1 PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 2 enzyme binding#GO:0019899;binding#GO:0005488;guanyl-nucleotide exchange factor activity#GO:0005085;protein binding#GO:0005515;enzyme regulator activity#GO:0030234;small GTPase binding#GO:0031267;molecular function regulator activity#GO:0098772;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589 cellular process#GO:0009987;regulation of actin filament organization#GO:0110053;biological regulation#GO:0065007;regulation of actin polymerization or depolymerization#GO:0008064;regulation of actin cytoskeleton organization#GO:0032956;regulation of actin filament polymerization#GO:0030833;regulation of anatomical structure size#GO:0090066;regulation of actin filament-based process#GO:0032970;cellular component organization or biogenesis#GO:0071840;regulation of supramolecular fiber organization#GO:1902903;regulation of cellular component size#GO:0032535;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;cellular component organization#GO:0016043;regulation of protein-containing complex assembly#GO:0043254;regulation of cellular component biogenesis#GO:0044087;regulation of cellular component organization#GO:0051128;regulation of protein polymerization#GO:0032271;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794;regulation of actin filament length#GO:0030832;regulation of biological quality#GO:0065008 HUMAN|HGNC=14202|UniProtKB=Q9BR39 Q9BR39 JPH2 PTHR23085:SF26 GH28348P JUNCTOPHILIN-2 plasma membrane#GO:0005886;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;sarcoplasmic reticulum#GO:0016529;cell periphery#GO:0071944;membrane#GO:0016020;organelle membrane#GO:0031090;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;sarcoplasm#GO:0016528 HUMAN|HGNC=32696|UniProtKB=A8MYV0 A8MYV0 DCDC2C PTHR23004:SF9 DOUBLECORTIN DOMAIN CONTAINING 2 DOUBLECORTIN DOMAIN-CONTAINING PROTEIN 2C intracellular membraneless organelle#GO:0043232;supramolecular complex#GO:0099080;organelle#GO:0043226;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;microtubule cytoskeleton#GO:0015630;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856 HUMAN|HGNC=10974|UniProtKB=Q9UHI7 Q9UHI7 SLC23A1 PTHR11119:SF21 XANTHINE-URACIL / VITAMIN C PERMEASE FAMILY MEMBER SOLUTE CARRIER FAMILY 23 MEMBER 1 secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;solute:monoatomic cation symporter activity#GO:0015294;monoatomic ion transmembrane transporter activity#GO:0015075;sugar transmembrane transporter activity#GO:0051119;symporter activity#GO:0015293;carboxylic acid transmembrane transporter activity#GO:0046943;monoatomic cation transmembrane transporter activity#GO:0008324;carbohydrate transmembrane transporter activity#GO:0015144;solute:sodium symporter activity#GO:0015370 establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;transport#GO:0006810;organic acid transport#GO:0015849;carboxylic acid transport#GO:0046942;carbohydrate transport#GO:0008643;carbohydrate transmembrane transport#GO:0034219;vitamin transport#GO:0051180;carboxylic acid transmembrane transport#GO:1905039;cellular process#GO:0009987 membrane#GO:0016020;apical plasma membrane#GO:0016324;cell periphery#GO:0071944;apical part of cell#GO:0045177;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;plasma membrane#GO:0005886 transporter#PC00227 HUMAN|HGNC=23080|UniProtKB=Q7RTY7 Q7RTY7 OVCH1 PTHR24251:SF21 OVOCHYMASE-RELATED OVOCHYMASE-1 protease#PC00190;serine protease#PC00203 HUMAN|HGNC=37203|UniProtKB=B2RUY7 B2RUY7 VWC2L PTHR46252:SF2 BRORIN FAMILY MEMBER VON WILLEBRAND FACTOR C DOMAIN-CONTAINING PROTEIN 2-LIKE negative regulation of cell communication#GO:0010648;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of BMP signaling pathway#GO:0030514;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;negative regulation of response to stimulus#GO:0048585;negative regulation of signal transduction#GO:0009968;regulation of cellular response to growth factor stimulus#GO:0090287;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of BMP signaling pathway#GO:0030510 cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;extracellular region#GO:0005576;signaling receptor complex#GO:0043235;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495 HUMAN|HGNC=2952|UniProtKB=Q96JB1 Q96JB1 DNAH8 PTHR10676:SF361 DYNEIN HEAVY CHAIN FAMILY PROTEIN DYNEIN AXONEMAL HEAVY CHAIN 8 macromolecular conformation isomerase activity#GO:0120543;catalytic activity#GO:0003824;isomerase activity#GO:0016853;cytoskeletal motor activity#GO:0003774;ATP-dependent activity#GO:0140657;binding#GO:0005488;polypeptide conformation or assembly isomerase activity#GO:0120544;microtubule motor activity#GO:0003777;protein binding#GO:0005515 cell projection assembly#GO:0030031;outer dynein arm assembly#GO:0036158;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cilium movement involved in cell motility#GO:0060294;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;plasma membrane bounded cell projection assembly#GO:0120031;protein-containing complex organization#GO:0043933;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cell projection organization#GO:0030030;cell motility#GO:0048870;microtubule-based movement#GO:0007018;cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;axonemal dynein complex assembly#GO:0070286;microtubule bundle formation#GO:0001578;organelle assembly#GO:0070925;axoneme assembly#GO:0035082;cilium organization#GO:0044782;cilium-dependent cell motility#GO:0060285;microtubule cytoskeleton organization#GO:0000226 dynein complex#GO:0030286;axonemal dynein complex#GO:0005858;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;motile cilium#GO:0031514;cilium#GO:0005929;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;9+2 motile cilium#GO:0097729;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;axoneme#GO:0005930;microtubule cytoskeleton#GO:0015630;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ciliary plasm#GO:0097014;protein-containing complex#GO:0032991;sperm flagellum#GO:0036126;microtubule associated complex#GO:0005875;outer dynein arm#GO:0036157;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 Huntington disease#P00029>Dynein complex#P00774 HUMAN|HGNC=16015|UniProtKB=Q9H8S9 Q9H8S9 MOB1A PTHR22599:SF30 MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB MOB KINASE ACTIVATOR 1A protein kinase regulator activity#GO:0019887;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;protein kinase activator activity#GO:0030295;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;kinase activator activity#GO:0019209 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;biological regulation#GO:0065007;signaling#GO:0023052;hippo signaling#GO:0035329;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 kinase activator#PC00138 CCKR signaling map#P06959>MOB1#G07283;CCKR signaling map#P06959>MOB1#G06990 HUMAN|HGNC=10812|UniProtKB=Q96BR1 Q96BR1 SGK3 PTHR24356:SF121 SERINE/THREONINE-PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE SGK3 transporter regulator activity#GO:0141108;potassium channel regulator activity#GO:0015459;protein serine/threonine kinase activity#GO:0004674;channel regulator activity#GO:0016247;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;ion channel regulator activity#GO:0099106;molecular function regulator activity#GO:0098772;catalytic activity, acting on a protein#GO:0140096 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=17453|UniProtKB=Q86UV6 Q86UV6 TRIM74 PTHR24103:SF662 E3 UBIQUITIN-PROTEIN LIGASE TRIM TRIPARTITE MOTIF-CONTAINING PROTEIN 73-RELATED ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 defense response to other organism#GO:0098542;response to stimulus#GO:0050896;response to other organism#GO:0051707;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;immune response#GO:0006955;defense response to symbiont#GO:0140546;innate immune response#GO:0045087;defense response#GO:0006952;response to external stimulus#GO:0009605;immune system process#GO:0002376 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=22223|UniProtKB=Q7L9B9 Q7L9B9 EEPD1 PTHR21180:SF33 ENDONUCLEASE/EXONUCLEASE/PHOSPHATASE FAMILY DOMAIN-CONTAINING PROTEIN 1 ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE FAMILY DOMAIN-CONTAINING PROTEIN 1 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HUMAN|HGNC=15033|UniProtKB=Q8NGW6 Q8NGW6 OR6K6 PTHR26451:SF132 G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN OLFACTORY RECEPTOR 6K6 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;binding#GO:0005488;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 system process#GO:0003008;nervous system process#GO:0050877;sensory perception#GO:0007600;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;response to stimulus#GO:0050896;response to chemical#GO:0042221;detection of chemical stimulus#GO:0009593;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906 cellular anatomical structure#GO:0110165;membrane#GO:0016020 G-protein coupled receptor#PC00021 HUMAN|HGNC=20565|UniProtKB=Q86TB3 Q86TB3 ALPK2 PTHR47091:SF2 ALPHA-PROTEIN KINASE 2-RELATED ALPHA-PROTEIN KINASE 2 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=5856|UniProtKB=P0DOY2 P0DOY2 IGLC2 PTHR23266:SF283 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN LAMBDA CONSTANT 2-RELATED antigen binding#GO:0003823;binding#GO:0005488 immune response#GO:0006955;adaptive immune response#GO:0002250;response to stimulus#GO:0050896;immune effector process#GO:0002252;immune system process#GO:0002376;immunoglobulin mediated immune response#GO:0016064;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=601|UniProtKB=P02652 P02652 APOA2 PTHR11027:SF0 APOLIPOPROTEIN A-II APOLIPOPROTEIN A-II protein-lipid complex binding#GO:0071814;binding#GO:0005488;lipoprotein particle binding#GO:0071813;protein-containing complex binding#GO:0044877 macromolecule localization#GO:0033036;lipid homeostasis#GO:0055088;cholesterol transport#GO:0030301;homeostatic process#GO:0042592;lipid transport#GO:0006869;transport#GO:0006810;chemical homeostasis#GO:0048878;lipid localization#GO:0010876;organic hydroxy compound transport#GO:0015850;localization#GO:0051179;establishment of localization#GO:0051234;cholesterol homeostasis#GO:0042632;sterol transport#GO:0015918 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma lipoprotein particle#GO:0034358;high-density lipoprotein particle#GO:0034364;protein-lipid complex#GO:0032994;extracellular protein-containing complex#GO:0140392;extracellular region#GO:0005576;lipoprotein particle#GO:1990777 apolipoprotein#PC00052;transfer/carrier protein#PC00219 HUMAN|HGNC=23450|UniProtKB=A1L443 A1L443 NUTM2F PTHR22879:SF2 NUT FAMILY MEMBER 1 NUT FAMILY MEMBER 2F-RELATED HUMAN|HGNC=17045|UniProtKB=Q969G9 Q969G9 NKD1 PTHR22611:SF2 PROTEIN NAKED CUTICLE PROTEIN NAKED CUTICLE HOMOLOG 1 negative regulation of signaling#GO:0023057;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of Wnt signaling pathway#GO:0030178;negative regulation of response to stimulus#GO:0048585;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111;negative regulation of signal transduction#GO:0009968 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 Wnt signaling pathway#P00057>Naked#P01427 HUMAN|HGNC=14010|UniProtKB=Q8IWI9 Q8IWI9 MGA PTHR11267:SF32 T-BOX PROTEIN-RELATED MAX GENE-ASSOCIATED PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 cell fate specification#GO:0001708;developmental process#GO:0032502;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;cell fate commitment#GO:0045165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357 intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;chromatin#GO:0000785;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;transferase complex#GO:1990234;histone methyltransferase complex#GO:0035097;intracellular membrane-bounded organelle#GO:0043231;methyltransferase complex#GO:0034708;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;chromosome#GO:0005694;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013 Rel homology transcription factor#PC00252;immunoglobulin fold transcription factor#PC00251 HUMAN|HGNC=33936|UniProtKB=A0AAQ5BID4 A0AAQ5BID4 FAM153CP PTHR40712:SF2 FAMILY WITH SEQUENCE SIMILARITY 153 MEMBER C-RELATED FAMILY WITH SEQUENCE SIMILARITY 153 MEMBER C, PSEUDOGENE-RELATED HUMAN|HGNC=18786|UniProtKB=Q14320 Q14320 FAM50A PTHR12722:SF2 XAP-5 PROTEIN-RELATED PROTEIN FAM50A chromatin organization#GO:0006325;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=26416|UniProtKB=Q96NI8 Q96NI8 ZNF570 PTHR24377:SF720 IP01015P-RELATED ZINC FINGER PROTEIN 570 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=25242|UniProtKB=P69849 P69849 NOMO3 PTHR23303:SF14 CARBOXYPEPTIDASE REGULATORY REGION-CONTAINING BOS COMPLEX SUBUNIT NOMO1-RELATED intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 HUMAN|HGNC=13949|UniProtKB=Q9UIM3 Q9UIM3 FKBPL PTHR11242:SF9 ARYL HYDROCARBON RECEPTOR INTERACTING PROTEIN RELATED FK506-BINDING PROTEIN-LIKE metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein modification process#GO:0036211;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;protein folding#GO:0006457;protein maturation#GO:0051604;gene expression#GO:0010467 cellular anatomical structure#GO:0110165;membrane#GO:0016020 chaperone#PC00072 HUMAN|HGNC=4180|UniProtKB=Q04446 Q04446 GBE1 PTHR43651:SF15 1,4-ALPHA-GLUCAN-BRANCHING ENZYME 1,4-ALPHA-GLUCAN-BRANCHING ENZYME catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758;glycosyltransferase activity#GO:0016757 energy derivation by oxidation of organic compounds#GO:0015980;macromolecule metabolic process#GO:0043170;glycogen biosynthetic process#GO:0005978;generation of precursor metabolites and energy#GO:0006091;metabolic process#GO:0008152;carbohydrate biosynthetic process#GO:0016051;biosynthetic process#GO:0009058;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;glucan biosynthetic process#GO:0009250;polysaccharide biosynthetic process#GO:0000271;energy reserve metabolic process#GO:0006112;carbohydrate metabolic process#GO:0005975;polysaccharide metabolic process#GO:0005976;glucan metabolic process#GO:0044042;primary metabolic process#GO:0044238;glycogen metabolic process#GO:0005977 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 amylase#PC00048 HUMAN|HGNC=14090|UniProtKB=Q9NP90 Q9NP90 RAB9B PTHR47981:SF17 RAB FAMILY RAS-RELATED PROTEIN RAB-9B ribonucleoside triphosphate phosphatase activity#GO:0017111;molecular function regulator activity#GO:0098772;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924 cellular localization#GO:0051641;localization#GO:0051179;vacuole organization#GO:0007033;organelle assembly#GO:0070925;endocytosis#GO:0006897;cytosolic transport#GO:0016482;vesicle fusion#GO:0006906;cellular component organization#GO:0016043;establishment of localization#GO:0051234;import into cell#GO:0098657;cellular component organization or biogenesis#GO:0071840;vesicle organization#GO:0016050;receptor-mediated endocytosis#GO:0006898;endosomal transport#GO:0016197;phagocytosis#GO:0006909;intracellular transport#GO:0046907;phagolysosome assembly#GO:0001845;transport#GO:0006810;lytic vacuole organization#GO:0080171;vesicle-mediated transport#GO:0016192;organelle fusion#GO:0048284;cellular component assembly#GO:0022607;organelle membrane fusion#GO:0090174;membrane organization#GO:0061024;cellular component biogenesis#GO:0044085;retrograde transport, endosome to Golgi#GO:0042147;organelle organization#GO:0006996;membrane fusion#GO:0061025;lysosome organization#GO:0007040;cellular process#GO:0009987;establishment of localization in cell#GO:0051649 endomembrane system#GO:0012505;phagocytic vesicle#GO:0045335;late endosome#GO:0005770;vacuole#GO:0005773;cytoplasm#GO:0005737;lytic vacuole#GO:0000323;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;lysosome#GO:0005764;endocytic vesicle#GO:0030139;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768 small GTPase#PC00208 HUMAN|HGNC=11175|UniProtKB=O95219 O95219 SNX4 PTHR46596:SF1 SORTING NEXIN-4 SORTING NEXIN-4 phosphatidylinositol phosphate binding#GO:1901981;lipid binding#GO:0008289;phosphatidylinositol-3-phosphate binding#GO:0032266;binding#GO:0005488;phospholipid binding#GO:0005543 localization#GO:0051179;positive regulation of metabolic process#GO:0009893;positive regulation of organelle organization#GO:0010638;protein transport#GO:0015031;regulation of autophagosome assembly#GO:2000785;positive regulation of cellular component organization#GO:0051130;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;positive regulation of macroautophagy#GO:0016239;regulation of cellular component biogenesis#GO:0044087;regulation of autophagy#GO:0010506;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;positive regulation of catabolic process#GO:0009896;establishment of localization#GO:0051234;regulation of macroautophagy#GO:0016241;intracellular protein localization#GO:0008104;regulation of catabolic process#GO:0009894;transport#GO:0006810;positive regulation of cellular component biogenesis#GO:0044089;biological regulation#GO:0065007;macromolecule localization#GO:0033036;positive regulation of autophagy#GO:0010508;regulation of metabolic process#GO:0019222;establishment of protein localization#GO:0045184;positive regulation of biological process#GO:0048518;regulation of organelle assembly#GO:1902115;positive regulation of cellular process#GO:0048522 bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;early endosome membrane#GO:0031901;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;cytoplasm#GO:0005737;vesicle membrane#GO:0012506;membrane#GO:0016020;cell periphery#GO:0071944;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endosome membrane#GO:0010008;endosome#GO:0005768;organelle#GO:0043226;SNARE complex#GO:0031201;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;vesicle#GO:0031982 scaffold/adaptor protein#PC00226 HUMAN|HGNC=2646|UniProtKB=Q08477 Q08477 CYP4F3 PTHR24291:SF220 CYTOCHROME P450 FAMILY 4 CYTOCHROME P450 4F3 arachidonate metabolic process#GO:0019369;vitamin K metabolic process#GO:0042373;primary metabolic process#GO:0044238;ketone metabolic process#GO:0042180;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;small molecule catabolic process#GO:0044282;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;olefinic compound metabolic process#GO:0120254;oxoacid metabolic process#GO:0043436;cellular process#GO:0009987;long-chain fatty acid metabolic process#GO:0001676;icosanoid metabolic process#GO:0006690;lipid metabolic process#GO:0006629;unsaturated fatty acid metabolic process#GO:0033559;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262;oxygenase#PC00177 HUMAN|HGNC=29149|UniProtKB=Q6ZVD8 Q6ZVD8 PHLPP2 PTHR45752:SF10 LEUCINE-RICH REPEAT-CONTAINING PH DOMAIN LEUCINE-RICH REPEAT-CONTAINING PROTEIN PHOSPHATASE 2 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=24912|UniProtKB=Q4G0J3 Q4G0J3 LARP7 PTHR22792:SF159 LUPUS LA PROTEIN-RELATED LA-RELATED PROTEIN 7 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 RNA metabolism protein#PC00031 HUMAN|HGNC=17946|UniProtKB=Q9Y314 Q9Y314 NOSIP PTHR13063:SF10 ENOS INTERACTING PROTEIN NITRIC OXIDE SYNTHASE-INTERACTING PROTEIN catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=30830|UniProtKB=Q5TKA1 Q5TKA1 LIN9 PTHR21689:SF2 LIN-9 PROTEIN LIN-9 HOMOLOG DNA binding#GO:0003677;binding#GO:0005488;nucleic acid binding#GO:0003676 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of cell cycle#GO:0051726;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981 DNA metabolism protein#PC00009 HUMAN|HGNC=28486|UniProtKB=Q8NHS3 Q8NHS3 MFSD8 PTHR23510:SF83 INNER MEMBRANE TRANSPORT PROTEIN YAJR MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 8 monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;chloride transmembrane transporter activity#GO:0015108;passive transmembrane transporter activity#GO:0022803;chloride channel activity#GO:0005254;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic anion transmembrane transporter activity#GO:0008509;monoatomic anion channel activity#GO:0005253;channel activity#GO:0015267 lytic vacuole organization#GO:0080171;autophagosome maturation#GO:0097352;metabolic process#GO:0008152;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;lysosome organization#GO:0007040;cellular process#GO:0009987;autophagy#GO:0006914;organelle organization#GO:0006996;macroautophagy#GO:0016236;process utilizing autophagic mechanism#GO:0061919;vacuole organization#GO:0007033;cellular component disassembly#GO:0022411;cellular component organization#GO:0016043;protein-containing complex disassembly#GO:0032984;catabolic process#GO:0009056 vacuolar membrane#GO:0005774;lytic vacuole#GO:0000323;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;cytoplasm#GO:0005737;vacuole#GO:0005773;membrane#GO:0016020;lysosomal membrane#GO:0005765;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;lytic vacuole membrane#GO:0098852;lysosome#GO:0005764 HUMAN|HGNC=15016|UniProtKB=Q8NH00 Q8NH00 OR2T4 PTHR26453:SF316 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2T4 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 response to chemical#GO:0042221;response to stimulus#GO:0050896;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;detection of chemical stimulus#GO:0009593;system process#GO:0003008;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;sensory perception#GO:0007600;nervous system process#GO:0050877 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=14911|UniProtKB=Q9NYW5 Q9NYW5 TAS2R4 PTHR11394:SF55 TASTE RECEPTOR TYPE 2 TASTE RECEPTOR TYPE 2 MEMBER 4 bitter taste receptor activity#GO:0033038;molecular transducer activity#GO:0060089;taste receptor activity#GO:0008527;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 multicellular organismal process#GO:0032501;response to chemical#GO:0042221;response to stimulus#GO:0050896;sensory perception of bitter taste#GO:0050913;detection of chemical stimulus#GO:0009593;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;system process#GO:0003008;detection of chemical stimulus involved in sensory perception of bitter taste#GO:0001580;detection of chemical stimulus involved in sensory perception of taste#GO:0050912;nervous system process#GO:0050877;sensory perception#GO:0007600;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;sensory perception of taste#GO:0050909 membrane#GO:0016020;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=24437|UniProtKB=Q96KP4 Q96KP4 CNDP2 PTHR43270:SF11 BETA-ALA-HIS DIPEPTIDASE CYTOSOLIC NON-SPECIFIC DIPEPTIDASE catalytic activity#GO:0003824;peptidase activity#GO:0008233;exopeptidase activity#GO:0008238;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;cellular process#GO:0009987;metabolic process#GO:0008152;proteolysis#GO:0006508;primary metabolic process#GO:0044238 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 metalloprotease#PC00153 HUMAN|HGNC=28814|UniProtKB=Q96DC7 Q96DC7 TMCO6 PTHR16356:SF1 TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 6 TMCO6 TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 6 HUMAN|HGNC=16928|UniProtKB=Q9BYR3 Q9BYR3 KRTAP4-4 PTHR23262:SF201 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 4-4 structural protein#PC00211 HUMAN|HGNC=30029|UniProtKB=Q32NB8 Q32NB8 PGS1 PTHR12586:SF1 CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE, MITOCHONDRIAL transferase#PC00220 HUMAN|HGNC=25969|UniProtKB=Q6ZN54 Q6ZN54 DEF8 PTHR12326:SF3 PLECKSTRIN HOMOLOGY DOMAIN CONTAINING PROTEIN DIFFERENTIALLY EXPRESSED IN FDCP 8 HOMOLOG HUMAN|HGNC=13309|UniProtKB=Q9NQ84 Q9NQ84 GPRC5C PTHR14511:SF15 G PROTEIN COUPLED RECEPTOR, CLASS C, GROUP 5 G PROTEIN-COUPLED RECEPTOR FAMILY C GROUP 5 MEMBER C kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;protein kinase regulator activity#GO:0019887;enzyme activator activity#GO:0008047;protein kinase activator activity#GO:0030295;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;kinase activator activity#GO:0019209 extracellular region#GO:0005576;signaling receptor complex#GO:0043235;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cell periphery#GO:0071944;vesicle#GO:0031982;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226 G-protein coupled receptor#PC00021 HUMAN|HGNC=17067|UniProtKB=Q9BWQ8 Q9BWQ8 FAIM2 PTHR23291:SF18 BAX INHIBITOR-RELATED PROTEIN LIFEGUARD 2 monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873;passive transmembrane transporter activity#GO:0022803;calcium channel activity#GO:0005262;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085 cellular process#GO:0009987;signal transduction#GO:0007165;negative regulation of programmed cell death#GO:0043069;negative regulation of neuron apoptotic process#GO:0043524;response to stress#GO:0006950;regulation of neuron apoptotic process#GO:0043523;negative regulation of signal transduction#GO:0009968;regulation of apoptotic process#GO:0042981;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;response to topologically incorrect protein#GO:0035966;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of signaling#GO:0023051;cellular response to stress#GO:0033554;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648;response to unfolded protein#GO:0006986;negative regulation of extrinsic apoptotic signaling pathway#GO:2001237;endoplasmic reticulum unfolded protein response#GO:0030968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of response to stimulus#GO:0048585;negative regulation of apoptotic process#GO:0043066;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;cellular response to stimulus#GO:0051716;regulation of extrinsic apoptotic signaling pathway#GO:2001236;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;cellular response to topologically incorrect protein#GO:0035967;regulation of apoptotic signaling pathway#GO:2001233;negative regulation of apoptotic signaling pathway#GO:2001234;cellular response to unfolded protein#GO:0034620;response to endoplasmic reticulum stress#GO:0034976;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=32523|UniProtKB=A8MVU1 A8MVU1 NCF1C PTHR15706:SF6 SH3 MULTIPLE DOMAIN NEUTROPHIL CYTOSOL FACTOR 1-RELATED enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme activator activity#GO:0008047 superoxide metabolic process#GO:0006801;cellular process#GO:0009987;metabolic process#GO:0008152;reactive oxygen species metabolic process#GO:0072593 cytoplasm#GO:0005737;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;oxidoreductase complex#GO:1990204;membrane#GO:0016020;membrane protein complex#GO:0098796;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494 scaffold/adaptor protein#PC00226 HUMAN|HGNC=6397|UniProtKB=O00629 O00629 KPNA4 PTHR23316:SF7 IMPORTIN ALPHA IMPORTIN SUBUNIT ALPHA-3 nucleocytoplasmic carrier activity#GO:0140142;molecular carrier activity#GO:0140104 cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;protein localization to nucleus#GO:0034504;macromolecule localization#GO:0033036;import into nucleus#GO:0051170;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;protein localization to organelle#GO:0033365;protein transport#GO:0015031;protein import into nucleus#GO:0006606;nuclear transport#GO:0051169;cellular localization#GO:0051641;localization#GO:0051179;NLS-bearing protein import into nucleus#GO:0006607;nucleocytoplasmic transport#GO:0006913 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 transporter#PC00227 HUMAN|HGNC=30273|UniProtKB=Q92930 Q92930 RAB8B PTHR47980:SF6 LD44762P RAS-RELATED PROTEIN RAB-8B exocytosis#GO:0006887;vesicle-mediated transport to the plasma membrane#GO:0098876;endosomal transport#GO:0016197;establishment of localization#GO:0051234;transport#GO:0006810;intracellular transport#GO:0046907;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;secretion by cell#GO:0032940;localization#GO:0051179;cellular localization#GO:0051641;secretion#GO:0046903;localization within membrane#GO:0051668;export from cell#GO:0140352;endocytic recycling#GO:0032456 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular vesicle#GO:0097708;coated vesicle#GO:0030135;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;intracellular organelle#GO:0043229;trans-Golgi network transport vesicle#GO:0030140;cytoplasm#GO:0005737;plasma membrane#GO:0005886;endomembrane system#GO:0012505;transport vesicle#GO:0030133;cell periphery#GO:0071944;membrane#GO:0016020;clathrin-coated vesicle#GO:0030136;Golgi-associated vesicle#GO:0005798 HUMAN|HGNC=5665|UniProtKB=A0A0J9YVY3 A0A0J9YVY3 IGHV7-4-1 PTHR23266:SF286 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 7-4-1 binding#GO:0005488;antigen binding#GO:0003823 lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;immune system process#GO:0002376;immune effector process#GO:0002252;response to stimulus#GO:0050896;adaptive immune response#GO:0002250;immune response#GO:0006955 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=15576|UniProtKB=Q8WXR4 Q8WXR4 MYO3B PTHR46256:SF1 AGAP011099-PA MYOSIN-IIIB polypeptide conformation or assembly isomerase activity#GO:0120544;protein serine/threonine kinase activity#GO:0004674;ATP-dependent activity#GO:0140657;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;transferase activity#GO:0016740;catalytic activity#GO:0003824;microfilament motor activity#GO:0000146;transferase activity, transferring phosphorus-containing groups#GO:0016772;macromolecular conformation isomerase activity#GO:0120543;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;cytoskeletal motor activity#GO:0003774;isomerase activity#GO:0016853 cellular component organization or biogenesis#GO:0071840;regulation of anatomical structure size#GO:0090066;regulation of actin cytoskeleton organization#GO:0032956;positive regulation of cellular component biogenesis#GO:0044089;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of biological quality#GO:0065008;positive regulation of cellular component organization#GO:0051130;regulation of actin filament length#GO:0030832;nervous system process#GO:0050877;regulation of cellular component biogenesis#GO:0044087;sensory perception of sound#GO:0007605;regulation of cellular component organization#GO:0051128;regulation of plasma membrane bounded cell projection assembly#GO:0120032;regulation of cellular component size#GO:0032535;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;cellular component organization#GO:0016043;regulation of filopodium assembly#GO:0051489;system process#GO:0003008;regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of cell projection organization#GO:0031344;regulation of actin filament-based process#GO:0032970;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;positive regulation of cellular process#GO:0048522;regulation of cell projection assembly#GO:0060491;sensory perception of mechanical stimulus#GO:0050954;sensory perception#GO:0007600;positive regulation of cell projection organization#GO:0031346;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794 cluster of actin-based cell projections#GO:0098862;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;filopodium#GO:0030175;photoreceptor inner segment#GO:0001917;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;actin-based cell projection#GO:0098858;actin cytoskeleton#GO:0015629;membraneless organelle#GO:0043228;stereocilium#GO:0032420;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;neuron projection#GO:0043005 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Myosin#P00867;Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097;Cytoskeletal regulation by Rho GTPase#P00016>Myosin#P00522 HUMAN|HGNC=25457|UniProtKB=Q8N3F0 Q8N3F0 MTURN PTHR32008:SF2 MATURIN MATURIN regulation of myeloid cell differentiation#GO:0045637;regulation of signaling#GO:0023051;regulation of hemopoiesis#GO:1903706;regulation of biological process#GO:0050789;regulation of multicellular organismal development#GO:2000026;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of developmental process#GO:0050793;positive regulation of developmental process#GO:0051094;positive regulation of cell differentiation#GO:0045597;regulation of cell differentiation#GO:0045595;positive regulation of myeloid cell differentiation#GO:0045639;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of cell development#GO:0060284;biological regulation#GO:0065007;regulation of multicellular organismal process#GO:0051239 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=30936|UniProtKB=P16415 P16415 ZNF823 PTHR24379:SF27 KRAB AND ZINC FINGER DOMAIN-CONTAINING ZINC FINGER PROTEIN 823 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HUMAN|HGNC=26483|UniProtKB=Q96MS3 Q96MS3 GLT1D1 PTHR46660:SF2 FAMILY NOT NAMED GLYCOSYLTRANSFERASE 1 DOMAIN-CONTAINING PROTEIN 1 HUMAN|HGNC=26335|UniProtKB=Q96LP2 Q96LP2 FAM81B PTHR22420:SF5 PROTEIN FAM81A PROTEIN FAM81B HUMAN|HGNC=5120|UniProtKB=P17482 P17482 HOXB9 PTHR45970:SF5 AGAP004664-PA HOMEOBOX PROTEIN HOX-B9 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;developmental process#GO:0032502;regulation of nucleobase-containing compound metabolic process#GO:0019219;regionalization#GO:0003002;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;skeletal system morphogenesis#GO:0048705;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;pattern specification process#GO:0007389;embryo development ending in birth or egg hatching#GO:0009792;embryonic organ development#GO:0048568;regulation of macromolecule metabolic process#GO:0060255;animal organ morphogenesis#GO:0009887;regulation of cellular process#GO:0050794;multicellular organism development#GO:0007275;embryonic morphogenesis#GO:0048598;animal organ development#GO:0048513;anterior/posterior pattern specification#GO:0009952;embryo development#GO:0009790;skeletal system development#GO:0001501;chordate embryonic development#GO:0043009;animal gross anatomical part developmental process#GO:0160108;regulation of transcription by RNA polymerase II#GO:0006357;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119 HUMAN|HGNC=30453|UniProtKB=Q96ET8 Q96ET8 TVP23C PTHR13019:SF23 GOLGI APPARATUS MEMBRANE PROTEIN TVP23 GOLGI APPARATUS MEMBRANE PROTEIN TVP23 HOMOLOG C protein secretion#GO:0009306;localization#GO:0051179;secretion#GO:0046903;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;secretion by cell#GO:0032940;protein transport#GO:0015031;establishment of protein localization to extracellular region#GO:0035592;transport#GO:0006810;vesicle-mediated transport#GO:0016192;export from cell#GO:0140352;macromolecule localization#GO:0033036;establishment of protein localization#GO:0045184;cellular process#GO:0009987;protein localization to extracellular region#GO:0071692 membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=17562|UniProtKB=Q969L4 Q969L4 LSM10 PTHR21196:SF1 U7 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM10 U7 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM10 RNA binding#GO:0003723;snRNA binding#GO:0017069;binding#GO:0005488;nucleic acid binding#GO:0003676 RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;mRNA 3'-end processing#GO:0031124;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187 ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;nuclear body#GO:0016604;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membraneless organelle#GO:0043228;nucleoplasm#GO:0005654;organelle#GO:0043226;cytoplasmic ribonucleoprotein granule#GO:0036464;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 HUMAN|HGNC=1968|UniProtKB=Q99698 Q99698 LYST PTHR13743:SF86 BEIGE/BEACH-RELATED LYSOSOMAL-TRAFFICKING REGULATOR cellular component organization or biogenesis#GO:0071840;vacuole organization#GO:0007033;cellular component organization#GO:0016043;organelle organization#GO:0006996;lysosome organization#GO:0007040;cellular process#GO:0009987;lytic vacuole organization#GO:0080171 lysosome#GO:0005764;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vacuole#GO:0005773;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;lytic vacuole#GO:0000323;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HUMAN|HGNC=10263|UniProtKB=P56715 P56715 RP1 PTHR23005:SF4 RETINITIS PIGMENTOSA 1 PROTEIN OXYGEN-REGULATED PROTEIN 1 neuron development#GO:0048666;cilium organization#GO:0044782;eye development#GO:0001654;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell development#GO:0048468;cellular component organization#GO:0016043;cilium assembly#GO:0060271;animal organ development#GO:0048513;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;neuron differentiation#GO:0030182;anatomical structure homeostasis#GO:0060249;cellular component assembly#GO:0022607;retina development in camera-type eye#GO:0060041;nervous system development#GO:0007399;cytoskeleton organization#GO:0007010;sensory system development#GO:0048880;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cell projection assembly#GO:0030031;microtubule cytoskeleton organization#GO:0000226;anatomical structure development#GO:0048856;retina homeostasis#GO:0001895;tissue homeostasis#GO:0001894;system development#GO:0048731;axoneme assembly#GO:0035082;camera-type eye development#GO:0043010;organelle assembly#GO:0070925;microtubule bundle formation#GO:0001578;visual system development#GO:0150063;homeostatic process#GO:0042592;cellular developmental process#GO:0048869;multicellular organismal-level homeostasis#GO:0048871;neurogenesis#GO:0022008;sensory organ development#GO:0007423;plasma membrane bounded cell projection assembly#GO:0120031;developmental process#GO:0032502;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;non-motile cilium#GO:0097730;axoneme#GO:0005930;cilium#GO:0005929;intracellular organelle#GO:0043229;ciliary transition zone#GO:0035869;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;ciliary plasm#GO:0097014;neuron projection#GO:0043005;photoreceptor cell cilium#GO:0097733;9+0 non-motile cilium#GO:0097731 HUMAN|HGNC=11755|UniProtKB=P04155 P04155 TFF1 PTHR13826:SF18 INTESTINAL TREFOIL FACTOR-RELATED TREFOIL FACTOR 1 homeostatic process#GO:0042592;epithelial structure maintenance#GO:0010669;multicellular organismal process#GO:0032501;anatomical structure homeostasis#GO:0060249;digestion#GO:0007586;multicellular organismal-level homeostasis#GO:0048871;system process#GO:0003008;tissue homeostasis#GO:0001894 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 CCKR signaling map#P06959>TFF1#G07287;CCKR signaling map#P06959>TFF1#G06993 HUMAN|HGNC=30765|UniProtKB=Q9UKE5 Q9UKE5 TNIK PTHR48015:SF39 SERINE/THREONINE-PROTEIN KINASE TAO TRAF2 AND NCK-INTERACTING PROTEIN KINASE catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674 regulation of MAPK cascade#GO:0043408;regulation of response to stimulus#GO:0048583;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124;signal transduction#GO:0007165;cellular process#GO:0009987;cell communication#GO:0007154;MAPK cascade#GO:0000165;intracellular signal transduction#GO:0035556;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of cell communication#GO:0010646;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=2321|UniProtKB=P36551 P36551 CPOX PTHR10755:SF0 COPROPORPHYRINOGEN III OXIDASE, MITOCHONDRIAL OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;catalytic activity#GO:0003824 cellular process#GO:0009987;heme biosynthetic process#GO:0006783;pigment metabolic process#GO:0042440;biosynthetic process#GO:0009058;heme metabolic process#GO:0042168;tetrapyrrole biosynthetic process#GO:0033014;pigment biosynthetic process#GO:0046148;porphyrin-containing compound metabolic process#GO:0006778;tetrapyrrole metabolic process#GO:0033013;metabolic process#GO:0008152;porphyrin-containing compound biosynthetic process#GO:0006779 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 oxidoreductase#PC00176;oxidase#PC00175;metabolite interconversion enzyme#PC00262 Heme biosynthesis#P02746>Coproporphyrinogen Oxidase (oxygen dependent)#P02980 HUMAN|HGNC=20561|UniProtKB=Q96CC6 Q96CC6 RHBDF1 PTHR45965:SF4 INACTIVE RHOMBOID PROTEIN INACTIVE RHOMBOID PROTEIN 1 regulation of transport#GO:0051049;regulation of localization#GO:0032879;regulation of response to stimulus#GO:0048583;regulation of epidermal growth factor receptor signaling pathway#GO:0042058;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of secretion by cell#GO:1903530;regulation of establishment of protein localization#GO:0070201;regulation of protein localization#GO:0032880;regulation of secretion#GO:0051046;regulation of signaling#GO:0023051;regulation of cell communication#GO:0010646;regulation of protein transport#GO:0051223;regulation of cellular process#GO:0050794;regulation of protein secretion#GO:0050708;regulation of biological process#GO:0050789;regulation of ERBB signaling pathway#GO:1901184 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229 serine protease#PC00203 HUMAN|HGNC=53119|UniProtKB=A0A0J9YX94 A0A0J9YX94 PNMA6F PTHR23095:SF49 PARANEOPLASTIC ANTIGEN PARANEOPLASTIC ANTIGEN MA6F transcription cofactor#PC00217 HUMAN|HGNC=7441|UniProtKB=P46199 P46199 MTIF2 PTHR43381:SF20 TRANSLATION INITIATION FACTOR IF-2-RELATED TRANSLATION INITIATION FACTOR IF-2, MITOCHONDRIAL translation factor activity#GO:0180051;translation initiation factor activity#GO:0003743 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;mitochondrial translation#GO:0032543;translation#GO:0006412;translational initiation#GO:0006413;metabolic process#GO:0008152;mitochondrial gene expression#GO:0140053;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 translation initiation factor#PC00224 HUMAN|HGNC=25917|UniProtKB=Q96SL8 Q96SL8 FIZ1 PTHR24383:SF13 ZINC FINGER PROTEIN FLT3-INTERACTING ZINC FINGER PROTEIN 1 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=5669|UniProtKB=A0A0B4J1V7 A0A0B4J1V7 IGHV7-81 PTHR23266:SF377 IMMUNOGLOBULIN HEAVY CHAIN NON-FUNCTIONAL IMMUNOGLOBULIN HEAVY VARIABLE 7-81-RELATED binding#GO:0005488;antigen binding#GO:0003823 immune response#GO:0006955;response to stimulus#GO:0050896;adaptive immune response#GO:0002250;immune system process#GO:0002376;immune effector process#GO:0002252;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=11605|UniProtKB=O95947 O95947 TBX6 PTHR11267:SF100 T-BOX PROTEIN-RELATED T-BOX TRANSCRIPTION FACTOR TBX6 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;cell fate specification#GO:0001708;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;cell fate commitment#GO:0045165 chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 Rel homology transcription factor#PC00252;immunoglobulin fold transcription factor#PC00251 HUMAN|HGNC=18183|UniProtKB=Q8TF64 Q8TF64 GIPC3 PTHR12259:SF2 RGS-GAIP INTERACTING PROTEIN GIPC PDZ DOMAIN-CONTAINING PROTEIN GIPC3 scaffold/adaptor protein#PC00226 HUMAN|HGNC=9875|UniProtKB=Q13972 Q13972 RASGRF1 PTHR23113:SF193 GUANINE NUCLEOTIDE EXCHANGE FACTOR RAS-SPECIFIC GUANINE NUCLEOTIDE-RELEASING FACTOR 1 guanyl-nucleotide exchange factor activity#GO:0005085;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 Ras protein signal transduction#GO:0007265;regulation of signaling#GO:0023051;cell communication#GO:0007154;regulation of biological quality#GO:0065008;intracellular signal transduction#GO:0035556;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;regulation of synaptic plasticity#GO:0048167;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of trans-synaptic signaling#GO:0099177;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;intracellular signaling cassette#GO:0141124 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=8921|UniProtKB=Q92576 Q92576 PHF3 PTHR11477:SF10 TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN PHD FINGER PROTEIN 3 general transcription factor#PC00259;RNA metabolism protein#PC00031 HUMAN|HGNC=14491|UniProtKB=Q9NQ50 Q9NQ50 MRPL40 PTHR13359:SF2 39S RIBOSOMAL PROTEIN L40, MITOCHONDRIAL LARGE RIBOSOMAL SUBUNIT PROTEIN ML40 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 gene expression#GO:0010467;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;translation#GO:0006412 membrane-enclosed lumen#GO:0031974;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;mitochondrial large ribosomal subunit#GO:0005762;membraneless organelle#GO:0043228;organelle lumen#GO:0043233;mitochondrion#GO:0005739;ribosome#GO:0005840;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;large ribosomal subunit#GO:0015934;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrial ribosome#GO:0005761;organellar ribosome#GO:0000313 ribosomal protein#PC00202;translational protein#PC00263 HUMAN|HGNC=32456|UniProtKB=Q2TAA5 Q2TAA5 ALG11 PTHR45919:SF1 GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;catalytic activity#GO:0003824;mannosyltransferase activity#GO:0000030;glycosyltransferase activity#GO:0016757 biosynthetic process#GO:0009058;protein N-linked glycosylation#GO:0006487;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100 endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 transferase#PC00220;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=27232|UniProtKB=Q96NL8 Q96NL8 CFAP418 PTHR33958:SF1 PROTEIN C8ORF37 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 418 neuron differentiation#GO:0030182;developmental process#GO:0032502;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;cellular process#GO:0009987;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;neuron development#GO:0048666;system development#GO:0048731;anatomical structure development#GO:0048856;anatomical structure morphogenesis#GO:0009653;cell development#GO:0048468;cell morphogenesis#GO:0000902;cell differentiation#GO:0030154 cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;ciliary base#GO:0097546;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cilium#GO:0005929 HUMAN|HGNC=16858|UniProtKB=Q92738 Q92738 USP6NL PTHR22957:SF193 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN USP6 N-TERMINAL-LIKE PROTEIN molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;enzyme activator activity#GO:0008047 establishment of localization#GO:0051234;vesicle-mediated transport#GO:0016192;localization#GO:0051179;transport#GO:0006810;cellular process#GO:0009987 intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410 G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HUMAN|HGNC=1781|UniProtKB=Q00532 Q00532 CDKL1 PTHR24056:SF192 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE-LIKE 1 phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=10303|UniProtKB=P26373 P26373 RPL13 PTHR11722:SF4 60S RIBOSOMAL PROTEIN L13 LARGE RIBOSOMAL SUBUNIT PROTEIN EL13 binding#GO:0005488;nucleic acid binding#GO:0003676;structural constituent of ribosome#GO:0003735;RNA binding#GO:0003723;structural molecule activity#GO:0005198 intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;ribosome#GO:0005840;cytosol#GO:0005829;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 ribosomal protein#PC00202 HUMAN|HGNC=19014|UniProtKB=Q8IWZ5 Q8IWZ5 TRIM42 PTHR25465:SF13 B-BOX DOMAIN CONTAINING TRIPARTITE MOTIF-CONTAINING PROTEIN 42 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=11868|UniProtKB=P48553 P48553 TRAPPC10 PTHR13251:SF3 EPILEPSY HOLOPROSENCEPHALY CANDIDATE 1/TMEM1 TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 10 guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234 intracellular transport#GO:0046907;transport#GO:0006810;Golgi vesicle transport#GO:0048193;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;endosomal transport#GO:0016197;retrograde transport, endosome to Golgi#GO:0042147;intra-Golgi vesicle-mediated transport#GO:0006891;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;cytosolic transport#GO:0016482 cytoplasm#GO:0005737;TRAPP complex#GO:0030008;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;intracellular protein-containing complex#GO:0140535;vesicle tethering complex#GO:0099023;TRAPPII protein complex#GO:1990071;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=12822|UniProtKB=Q9NQW7 Q9NQW7 XPNPEP1 PTHR43763:SF6 XAA-PRO AMINOPEPTIDASE 1 XAA-PRO AMINOPEPTIDASE 1 protease#PC00190 HUMAN|HGNC=4816|UniProtKB=P12081 P12081 HARS1 PTHR11476:SF8 HISTIDYL-TRNA SYNTHETASE HISTIDINE--TRNA LIGASE, CYTOPLASMIC binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;ligase activity#GO:0016874;catalytic activity, acting on RNA#GO:0140098 macromolecule metabolic process#GO:0043170;amino acid activation#GO:0043038;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;amino acid metabolic process#GO:0006520;tRNA aminoacylation#GO:0043039;tRNA aminoacylation for protein translation#GO:0006418;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;RNA metabolic process#GO:0016070;protein metabolic process#GO:0019538;mitochondrial gene expression#GO:0140053;translation#GO:0006412;mitochondrial translation#GO:0032543;protein biosynthetic process#GO:0160307;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 HUMAN|HGNC=23442|UniProtKB=Q5T764 Q5T764 IFIT1B PTHR10271:SF38 INTERFERON-INDUCED PROTEIN WITH TETRATRICOPEPTIDE REPEATS PROTEIN IFIT1 HOMOLOG B RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 immune system process#GO:0002376;response to virus#GO:0009615;response to peptide#GO:1901652;defense response to virus#GO:0051607;antiviral innate immune response#GO:0140374;cellular response to cytokine stimulus#GO:0071345;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;innate immune response#GO:0045087;defense response#GO:0006952;response to external stimulus#GO:0009605;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;immune response#GO:0006955;defense response to symbiont#GO:0140546;defense response to other organism#GO:0098542;response to cytokine#GO:0034097;response to chemical#GO:0042221;response to other organism#GO:0051707 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 defense/immunity protein#PC00090 HUMAN|HGNC=23094|UniProtKB=Q6ZSM3 Q6ZSM3 SLC16A12 PTHR11360:SF318 MONOCARBOXYLATE TRANSPORTER MONOCARBOXYLATE TRANSPORTER 12 transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;transporter activity#GO:0005215;monocarboxylic acid transmembrane transporter activity#GO:0008028 plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;basal part of cell#GO:0045178;basolateral plasma membrane#GO:0016323;membrane#GO:0016020;basal plasma membrane#GO:0009925;cell periphery#GO:0071944 transporter#PC00227 HUMAN|HGNC=31703|UniProtKB=Q32ZL2 Q32ZL2 PLPPR5 PTHR10165:SF17 LIPID PHOSPHATE PHOSPHATASE PHOSPHOLIPID PHOSPHATASE-RELATED PROTEIN TYPE 5 hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;phospholipid metabolic process#GO:0006644;signaling#GO:0023052;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;regulation of biological process#GO:0050789;phospholipid dephosphorylation#GO:0046839;cellular response to stimulus#GO:0051716;phosphate-containing compound metabolic process#GO:0006796;dephosphorylation#GO:0016311;cell communication#GO:0007154;biological regulation#GO:0065007;organophosphate metabolic process#GO:0019637;signal transduction#GO:0007165;cellular process#GO:0009987;lipid modification#GO:0030258;metabolic process#GO:0008152;lipid metabolic process#GO:0006629 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 hydrolase#PC00121;phosphatase#PC00181 HUMAN|HGNC=18755|UniProtKB=Q9NR33 Q9NR33 POLE4 PTHR10252:SF79 HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED DNA POLYMERASE EPSILON SUBUNIT 4 cellular process#GO:0009987;DNA replication#GO:0006260;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;DNA-templated DNA replication#GO:0006261;macromolecule metabolic process#GO:0043170 nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;chromatin#GO:0000785;membrane-enclosed lumen#GO:0031974;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;epsilon DNA polymerase complex#GO:0008622;membraneless organelle#GO:0043228;transferase complex#GO:1990234;DNA polymerase complex#GO:0042575;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;SWI/SNF superfamily-type complex#GO:0070603;chromosome#GO:0005694;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ISWI-type complex#GO:0031010;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ATPase complex#GO:1904949;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695 DNA-binding transcription factor#PC00218 HUMAN|HGNC=25813|UniProtKB=Q7Z2Y8 Q7Z2Y8 GVINP1 PTHR14819:SF5 GTP-BINDING INTERFERON-INDUCED VERY LARGE GTPASE 1 HUMAN|HGNC=5966|UniProtKB=P20809 P20809 IL11 PTHR16922:SF0 INTERLEUKIN 11 INTERLEUKIN-11 signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;receptor ligand activity#GO:0048018;cytokine activity#GO:0005125;growth factor activity#GO:0008083;signaling receptor regulator activity#GO:0030545 regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;positive regulation of signaling#GO:0023056;regulation of cell population proliferation#GO:0042127;regulation of biological process#GO:0050789;positive regulation of cell population proliferation#GO:0008284;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of response to stimulus#GO:0048583;regulation of MAPK cascade#GO:0043408;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of MAPK cascade#GO:0043410;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of response to stimulus#GO:0048584 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 interleukin superfamily#PC00128;cytokine#PC00083 Interleukin signaling pathway#P00036>Interleukin#P00970 HUMAN|HGNC=18150|UniProtKB=Q8IUG5 Q8IUG5 MYO18B PTHR45615:SF8 MYOSIN HEAVY CHAIN, NON-MUSCLE UNCONVENTIONAL MYOSIN-XVIIIB protein binding#GO:0005515;protein-containing complex binding#GO:0044877;polypeptide conformation or assembly isomerase activity#GO:0120544;binding#GO:0005488;ATP-dependent activity#GO:0140657;actin binding#GO:0003779;actin filament binding#GO:0051015;cytoskeletal motor activity#GO:0003774;isomerase activity#GO:0016853;catalytic activity#GO:0003824;microfilament motor activity#GO:0000146;macromolecular conformation isomerase activity#GO:0120543;cytoskeletal protein binding#GO:0008092 cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;actin cytoskeleton organization#GO:0030036;cytoskeleton organization#GO:0007010;actomyosin structure organization#GO:0031032;actin filament-based process#GO:0030029;cellular component organization or biogenesis#GO:0071840 membraneless organelle#GO:0043228;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;organelle#GO:0043226;supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;actin cytoskeleton#GO:0015629;myosin complex#GO:0016459 actin or actin-binding cytoskeletal protein#PC00041 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HUMAN|HGNC=30500|UniProtKB=Q7Z6L0 Q7Z6L0 PRRT2 PTHR14948:SF20 NG5 PROLINE-RICH TRANSMEMBRANE PROTEIN 2 organelle fusion#GO:0048284;vesicle-mediated transport#GO:0016192;neurotransmitter transport#GO:0006836;endomembrane system organization#GO:0010256;organelle membrane fusion#GO:0090174;organelle organization#GO:0006996;synaptic signaling#GO:0099536;synaptic vesicle exocytosis#GO:0016079;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;vesicle-mediated transport in synapse#GO:0099003;exocytosis#GO:0006887;vesicle organization#GO:0016050;regulated exocytosis#GO:0045055;vesicle fusion to plasma membrane#GO:0099500;exocytic process#GO:0140029;export from cell#GO:0140352;signaling#GO:0023052;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;cellular localization#GO:0051641;secretion by cell#GO:0032940;biological regulation#GO:0065007;membrane organization#GO:0061024;cell-cell signaling#GO:0007267;neurotransmitter secretion#GO:0007269;membrane fusion#GO:0061025;synaptic vesicle membrane organization#GO:0048499;establishment of localization#GO:0051234;synaptic vesicle cycle#GO:0099504;transport#GO:0006810;anterograde trans-synaptic signaling#GO:0098916;vesicle fusion#GO:0006906;signal release from synapse#GO:0099643;chemical synaptic transmission#GO:0007268;localization#GO:0051179;cell communication#GO:0007154;secretion#GO:0046903;signal release#GO:0023061;trans-synaptic signaling#GO:0099537;synaptic vesicle fusion to presynaptic active zone membrane#GO:0031629 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HUMAN|HGNC=3289|UniProtKB=Q13542 Q13542 EIF4EBP2 PTHR12669:SF4 EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 2 translation regulator activity#GO:0045182;translation initiation factor binding#GO:0031369;protein binding#GO:0005515;binding#GO:0005488 regulation of synaptic plasticity#GO:0048167;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;regulation of trans-synaptic signaling#GO:0099177;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of translational initiation#GO:0006446;negative regulation of translation#GO:0017148;regulation of signaling#GO:0023051;regulation of biological quality#GO:0065008;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;negative regulation of protein metabolic process#GO:0051248 translation initiation factor#PC00224;translation factor#PC00223 HUMAN|HGNC=5259|UniProtKB=Q58FF7 Q58FF7 HSP90AB3P PTHR11528:SF131 HEAT SHOCK PROTEIN 90 FAMILY MEMBER HEAT SHOCK PROTEIN HSP 90-ALPHA A2-RELATED hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887;anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167;ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleotide binding#GO:0000166;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP binding#GO:0005524;binding#GO:0005488;nucleoside phosphate binding#GO:1901265;ATP-dependent activity#GO:0140657;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;hydrolase activity, acting on acid anhydrides#GO:0016817 metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein stabilization#GO:0050821;cellular response to heat#GO:0034605;response to heat#GO:0009408;response to stress#GO:0006950;regulation of protein stability#GO:0031647;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;biological regulation#GO:0065007;response to temperature stimulus#GO:0009266;cellular response to stress#GO:0033554;protein metabolic process#GO:0019538;regulation of biological quality#GO:0065008;primary metabolic process#GO:0044238;response to abiotic stimulus#GO:0009628;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;protein folding#GO:0006457 intracellular anatomical structure#GO:0005622;membrane#GO:0016020;cytosol#GO:0005829;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;plasma membrane#GO:0005886;perinuclear region of cytoplasm#GO:0048471 chaperone#PC00072;Hsp90 family chaperone#PC00028 HUMAN|HGNC=26835|UniProtKB=Q8N8A8 Q8N8A8 FAM169BP PTHR22442:SF4 FAMILY NOT NAMED PROTEIN FAM169BP HUMAN|HGNC=17061|UniProtKB=Q9Y3D2 Q9Y3D2 MSRB2 PTHR10173:SF37 METHIONINE SULFOXIDE REDUCTASE METHIONINE-R-SULFOXIDE REDUCTASE B2, MITOCHONDRIAL oxidoreductase activity#GO:0016491;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;catalytic activity#GO:0003824 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 reductase#PC00198;metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HUMAN|HGNC=11960|UniProtKB=Q6Y7W6 Q6Y7W6 GIGYF2 PTHR14445:SF38 GRB10 INTERACTING GYF PROTEIN GRB10-INTERACTING GYF PROTEIN 2 translation regulator activity#GO:0045182 signaling#GO:0023052;negative regulation of metabolic process#GO:0009892;insulin-like growth factor receptor signaling pathway#GO:0048009;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of translational initiation#GO:0006446;negative regulation of translation#GO:0017148;signal transduction#GO:0007165;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of protein metabolic process#GO:0051246;cell surface receptor signaling pathway#GO:0007166;negative regulation of protein metabolic process#GO:0051248;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523 dendritic tree#GO:0097447;dendrite#GO:0030425;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;vesicle#GO:0031982;cell body#GO:0044297;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;neuronal cell body#GO:0043025;cellular anatomical structure#GO:0110165;organelle#GO:0043226;perikaryon#GO:0043204;neuron projection#GO:0043005;membrane#GO:0016020;cytosol#GO:0005829;cytoplasm#GO:0005737;somatodendritic compartment#GO:0036477 HUMAN|HGNC=11972|UniProtKB=O15405 O15405 TOX3 PTHR45781:SF3 AGAP000281-PA TOX HIGH MOBILITY GROUP BOX FAMILY MEMBER 3 chromatin binding#GO:0003682;chromatin DNA binding#GO:0031490;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA binding#GO:0003677 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA-binding transcription factor#PC00218;HMG box transcription factor#PC00024 HUMAN|HGNC=25166|UniProtKB=Q96E16 Q96E16 SMIM19 PTHR31888:SF1 SMALL INTEGRAL MEMBRANE PROTEIN 19 SMALL INTEGRAL MEMBRANE PROTEIN 19 HUMAN|HGNC=14331|UniProtKB=Q9NY87 Q9NY87 SPANXC PTHR23425:SF16 NUCLEOPORIN AMO1-LIKE SPERM PROTEIN ASSOCIATED WITH THE NUCLEUS ON THE X CHROMOSOME A-RELATED transporter#PC00227 HUMAN|HGNC=6009|UniProtKB=P14784 P14784 IL2RB PTHR23037:SF30 CYTOKINE RECEPTOR INTERLEUKIN-2 RECEPTOR SUBUNIT BETA signaling receptor activity#GO:0038023;cytokine binding#GO:0019955;immune receptor activity#GO:0140375;coreceptor activity#GO:0015026;cytokine receptor activity#GO:0004896;protein binding#GO:0005515;molecular transducer activity#GO:0060089;growth factor binding#GO:0019838;transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488 cellular response to stimulus#GO:0051716;interleukin-2-mediated signaling pathway#GO:0038110;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cytokine-mediated signaling pathway#GO:0019221;response to peptide#GO:1901652;cell communication#GO:0007154;cellular process#GO:0009987;signal transduction#GO:0007165;biological regulation#GO:0065007;response to cytokine#GO:0034097;response to chemical#GO:0042221;cell surface receptor signaling pathway#GO:0007166 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell surface#GO:0009986;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 Interleukin signaling pathway#P00036>Receptor subunit beta#P00974 HUMAN|HGNC=924|UniProtKB=P15291 P15291 B4GALT1 PTHR19300:SF5 BETA-1,4-GALACTOSYLTRANSFERASE BETA-1,4-GALACTOSYLTRANSFERASE 1 catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;galactosyltransferase activity#GO:0008378 glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487;biosynthetic process#GO:0009058 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 metabolite interconversion enzyme#PC00262;glycosyltransferase#PC00111 HUMAN|HGNC=11915|UniProtKB=Q9NS68 Q9NS68 TNFRSF19 PTHR12120:SF1 TNFR-CYS DOMAIN-CONTAINING PROTEIN TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 19 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;response to peptide#GO:1901652;cytokine-mediated signaling pathway#GO:0019221;cell surface receptor signaling pathway#GO:0007166;response to cytokine#GO:0034097;response to chemical#GO:0042221;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;signal transduction#GO:0007165;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 HUMAN|HGNC=24966|UniProtKB=Q9H063 Q9H063 MAF1 PTHR22504:SF0 REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 HOMOLOG RNA polymerase core enzyme binding#GO:0043175;protein binding#GO:0005515;enzyme binding#GO:0019899;RNA polymerase binding#GO:0070063;binding#GO:0005488 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 general transcription factor#PC00259;RNA metabolism protein#PC00031 HUMAN|HGNC=37073|UniProtKB=A6NHX0 A6NHX0 CASTOR2 PTHR31131:SF2 CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE CYTOSOLIC ARGININE SENSOR FOR MTORC1 SUBUNIT 2 negative regulation of cellular process#GO:0048523;negative regulation of TORC1 signaling#GO:1904262;regulation of response to stimulus#GO:0048583;regulation of TORC1 signaling#GO:1903432;cellular response to oxygen-containing compound#GO:1901701;response to acid chemical#GO:0001101;cellular process#GO:0009987;regulation of TOR signaling#GO:0032006;response to chemical#GO:0042221;cellular response to nitrogen compound#GO:1901699;negative regulation of response to stimulus#GO:0048585;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;cellular response to chemical stimulus#GO:0070887;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;response to oxygen-containing compound#GO:1901700;regulation of signaling#GO:0023051;negative regulation of intracellular signal transduction#GO:1902532;response to nitrogen compound#GO:1901698;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;negative regulation of TOR signaling#GO:0032007;cellular response to amino acid stimulus#GO:0071230;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=2846|UniProtKB=Q14129 Q14129 DGCR6 PTHR13054:SF7 DIGEORGE SYNDROME CRITICAL REGION 6 DGCR6 FAMILY MEMBER PROTEIN DGCR6 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=4079|UniProtKB=P31644 P31644 GABRA5 PTHR18945:SF23 NEUROTRANSMITTER GATED ION CHANNEL GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-5 monoatomic ion channel activity#GO:0005216;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion transmembrane transporter activity#GO:0015075;signaling receptor activity#GO:0038023;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;neurotransmitter receptor activity#GO:0030594;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;molecular transducer activity#GO:0060089;channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276;transmembrane signaling receptor activity#GO:0004888;gated channel activity#GO:0022836 monoatomic anion transport#GO:0006820;chemical synaptic transmission#GO:0007268;anterograde trans-synaptic signaling#GO:0098916;cell junction organization#GO:0034330;synapse organization#GO:0050808;trans-synaptic signaling#GO:0099537;system development#GO:0048731;chloride transmembrane transport#GO:1902476;cell communication#GO:0007154;localization#GO:0051179;anatomical structure development#GO:0048856;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;monoatomic ion transmembrane transport#GO:0034220;multicellular organismal process#GO:0032501;developmental process#GO:0032502;transport#GO:0006810;establishment of localization#GO:0051234;regulation of biological process#GO:0050789;cell junction assembly#GO:0034329;cellular component organization#GO:0016043;signaling#GO:0023052;synapse assembly#GO:0007416;animal gross anatomical part developmental process#GO:0160108;inorganic anion transport#GO:0015698;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;synaptic signaling#GO:0099536;nervous system development#GO:0007399;cellular component assembly#GO:0022607;monoatomic anion transmembrane transport#GO:0098656;chloride transport#GO:0006821;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840 cell projection membrane#GO:0031253;dendrite#GO:0030425;leading edge membrane#GO:0031256;dendritic tree#GO:0097447;cellular anatomical structure#GO:0110165;synapse#GO:0045202;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;postsynapse#GO:0098794;cell junction#GO:0030054;signaling receptor complex#GO:0043235;neuron projection membrane#GO:0032589;protein-containing complex#GO:0032991;plasma membrane region#GO:0098590;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;membrane#GO:0016020;cell leading edge#GO:0031252;cell periphery#GO:0071944;neuron projection#GO:0043005 ligand-gated ion channel#PC00141 HUMAN|HGNC=15854|UniProtKB=Q9Y2F9 Q9Y2F9 BTBD3 PTHR45774:SF2 BTB/POZ DOMAIN-CONTAINING BTB_POZ DOMAIN-CONTAINING PROTEIN 3 dendrite morphogenesis#GO:0048813;system development#GO:0048731;anatomical structure development#GO:0048856;plasma membrane bounded cell projection organization#GO:0120036;multicellular organismal process#GO:0032501;brain development#GO:0007420;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;cell development#GO:0048468;cell morphogenesis#GO:0000902;forebrain development#GO:0030900;central nervous system development#GO:0007417;cell differentiation#GO:0030154;cell projection organization#GO:0030030;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;neuron development#GO:0048666;dendrite development#GO:0016358;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;head development#GO:0060322;cellular process#GO:0009987;neuron projection development#GO:0031175;cell projection morphogenesis#GO:0048858;animal organ development#GO:0048513;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=14493|UniProtKB=Q9Y6G3 Q9Y6G3 MRPL42 PTHR13450:SF4 MITOCHONDRIAL 39S RIBOSOMAL PROTEIN L42 LARGE RIBOSOMAL SUBUNIT PROTEIN ML42 organelle lumen#GO:0043233;mitochondrion#GO:0005739;ribosome#GO:0005840;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;large ribosomal subunit#GO:0015934;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organellar ribosome#GO:0000313;mitochondrial ribosome#GO:0005761;membrane-enclosed lumen#GO:0031974;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;mitochondrial large ribosomal subunit#GO:0005762;membraneless organelle#GO:0043228 translational protein#PC00263;ribosomal protein#PC00202 HUMAN|HGNC=13919|UniProtKB=P46379 P46379 BAG6 PTHR15204:SF0 LARGE PROLINE-RICH PROTEIN BAG6 LARGE PROLINE-RICH PROTEIN BAG6 polyubiquitin modification-dependent protein binding#GO:0031593;modification-dependent protein binding#GO:0140030;binding#GO:0005488;protein binding#GO:0005515 protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;response to endoplasmic reticulum stress#GO:0034976;ERAD pathway#GO:0036503;protein metabolic process#GO:0019538;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;catabolic process#GO:0009056;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;response to stress#GO:0006950;proteasomal protein catabolic process#GO:0010498;response to chemical#GO:0042221 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 chaperone#PC00072 HUMAN|HGNC=26716|UniProtKB=Q8N9Q2 Q8N9Q2 SREK1IP1 PTHR31437:SF1 SREK1IP1 FAMILY MEMBER PROTEIN SREK1IP1 HUMAN|HGNC=26120|UniProtKB=Q8N0V3 Q8N0V3 RBFA PTHR14725:SF0 RIBOSOME-BINDING FACTOR A, MITOCHONDRIAL-RELATED RIBOSOME-BINDING FACTOR A, MITOCHONDRIAL-RELATED HUMAN|HGNC=14534|UniProtKB=Q08648 Q08648 SPAG11B PTHR14081:SF3 SPERM-ASSOCIATED ANTIGEN 11A-RELATED-RELATED SPERM-ASSOCIATED ANTIGEN 11A-RELATED HUMAN|HGNC=24097|UniProtKB=Q8WWN8 Q8WWN8 ARAP3 PTHR45899:SF4 RHO GTPASE ACTIVATING PROTEIN AT 15B, ISOFORM C ARF-GAP WITH RHO-GAP DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 3 phospholipid binding#GO:0005543;enzyme activator activity#GO:0008047;molecular function regulator activity#GO:0098772;phosphatidylinositol phosphate binding#GO:1901981;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;anion binding#GO:0043168;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;lipid binding#GO:0008289;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234 regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of actin cytoskeleton organization#GO:0032956;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;regulation of actin filament-based process#GO:0032970 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 GTPase-activating protein#PC00257 HUMAN|HGNC=7163|UniProtKB=Q9ULZ9 Q9ULZ9 MMP17 PTHR10201:SF21 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE-17 metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 extracellular structure organization#GO:0043062;metabolic process#GO:0008152;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;external encapsulating structure organization#GO:0045229;cellular component organization#GO:0016043;cellular process#GO:0009987;catabolic process#GO:0009056 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 Alzheimer disease-presenilin pathway#P00004>Membrane metalloprotease#P00141 HUMAN|HGNC=11738|UniProtKB=Q9BXT5 Q9BXT5 TEX15 PTHR22380:SF1 TESTIS-EXPRESSED PROTEIN 15 TESTIS-EXPRESSED PROTEIN 15 regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;male gamete generation#GO:0048232;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of response to stress#GO:0080134;regulation of response to stimulus#GO:0048583;regulation of DNA repair#GO:0006282;meiotic nuclear division#GO:0140013;meiotic chromosome segregation#GO:0045132;chromosome organization#GO:0051276;cell cycle#GO:0007049;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;reproductive process#GO:0022414;meiosis I cell cycle process#GO:0061982;sexual reproduction#GO:0019953;organelle fission#GO:0048285;multicellular organismal reproductive process#GO:0048609;regulation of double-strand break repair#GO:2000779;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cellular component assembly#GO:0022607;synaptonemal complex assembly#GO:0007130;homologous chromosome pairing at meiosis#GO:0007129;male meiotic nuclear division#GO:0007140;chromosome organization involved in meiotic cell cycle#GO:0070192;meiotic cell cycle#GO:0051321;chromosome segregation#GO:0007059;cellular component organization or biogenesis#GO:0071840;homologous chromosome segregation#GO:0045143;nuclear chromosome segregation#GO:0098813;meiotic cell cycle process#GO:1903046;cellular component organization#GO:0016043;meiosis I#GO:0007127;cell cycle process#GO:0022402;regulation of DNA metabolic process#GO:0051052;regulation of biological process#GO:0050789;gamete generation#GO:0007276;regulation of double-strand break repair via homologous recombination#GO:0010569;nuclear division#GO:0000280;regulation of DNA recombination#GO:0000018;regulation of cellular response to stress#GO:0080135 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=17164|UniProtKB=Q9BXK5 Q9BXK5 BCL2L13 PTHR15758:SF2 BCL-2-LIKE PROTEIN 13 BCL-2-LIKE PROTEIN 13 HUMAN|HGNC=4838|UniProtKB=P05546 P05546 SERPIND1 PTHR11461:SF30 SERINE PROTEASE INHIBITOR, SERPIN HEPARIN COFACTOR 2 molecular function inhibitor activity#GO:0140678;serine-type endopeptidase inhibitor activity#GO:0004867;enzyme regulator activity#GO:0030234;peptidase regulator activity#GO:0061134;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866;enzyme inhibitor activity#GO:0004857 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease inhibitor#PC00191 Blood coagulation#P00011>HCII#P00456 HUMAN|HGNC=31682|UniProtKB=P85299 P85299 PRR5 PTHR32428:SF4 TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT BIT61-RELATED PROLINE-RICH PROTEIN 5 protein kinase regulator activity#GO:0019887;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234 TORC2 signaling#GO:0038203;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051897;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;signaling#GO:0023052;regulation of cell communication#GO:0010646;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;cell communication#GO:0007154;positive regulation of signaling#GO:0023056;regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051896;intracellular signal transduction#GO:0035556;signal transduction#GO:0007165;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;TOR signaling#GO:0031929;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583 intracellular protein-containing complex#GO:0140535;TOR complex#GO:0038201;protein-containing complex#GO:0032991 PDGF signaling pathway#P00047>Rho#P01174;VEGF signaling pathway#P00056>Rac#P01421;Angiogenesis#P00005>Rac#P00245;Cytoskeletal regulation by Rho GTPase#P00016>Rho GAPs#P00520 HUMAN|HGNC=28793|UniProtKB=O95568 O95568 METTL18 PTHR14614:SF177 HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein methyltransferase activity#GO:0008276;catalytic activity, acting on a protein#GO:0140096;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;N-methyltransferase activity#GO:0008170 regulation of biological process#GO:0050789;regulation of protein metabolic process#GO:0051246;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;post-transcriptional regulation of gene expression#GO:0010608;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 protein modifying enzyme#PC00260 HUMAN|HGNC=23078|UniProtKB=Q9BQI9 Q9BQI9 NRIP2 PTHR12917:SF17 ASPARTYL PROTEASE DDI-RELATED NUCLEAR RECEPTOR-INTERACTING PROTEIN 2 aspartic-type endopeptidase activity#GO:0004190;catalytic activity#GO:0003824;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 cellular process#GO:0009987;metabolic process#GO:0008152;proteolysis#GO:0006508;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protein modifying enzyme#PC00260;aspartic protease#PC00053 HUMAN|HGNC=19142|UniProtKB=Q96QH8 Q96QH8 SPACA5 PTHR11407:SF31 LYSOZYME C SPERM ACROSOME-ASSOCIATED PROTEIN 5 hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787;lysozyme activity#GO:0003796;catalytic activity#GO:0003824;peptidoglycan muralytic activity#GO:0061783;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553 multicellular organismal reproductive process#GO:0048609;sexual reproduction#GO:0019953;fertilization#GO:0009566;cellular process involved in reproduction in multicellular organism#GO:0022412;reproductive process#GO:0022414;single fertilization#GO:0007338;fusion of sperm to egg plasma membrane involved in single fertilization#GO:0007342;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;motile cilium#GO:0031514;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;cell projection#GO:0042995;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;acrosomal vesicle#GO:0001669;9+2 motile cilium#GO:0097729;cilium#GO:0005929;intracellular organelle#GO:0043229;sperm flagellum#GO:0036126;endomembrane system#GO:0012505;cytoplasm#GO:0005737;secretory vesicle#GO:0099503 glycosidase#PC00110 HUMAN|HGNC=630|UniProtKB=Q13796 Q13796 SHROOM2 PTHR15012:SF8 APICAL PROTEIN/SHROOM-RELATED PROTEIN SHROOM2 actin binding#GO:0003779;actin filament binding#GO:0051015;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 actin filament-based process#GO:0030029;actin filament organization#GO:0007015;supramolecular fiber organization#GO:0097435;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036 intracellular organelle#GO:0043229;anchoring junction#GO:0070161;intracellular anatomical structure#GO:0005622;cortical cytoskeleton#GO:0030863;actin cytoskeleton#GO:0015629;apical plasma membrane#GO:0016324;cell cortex#GO:0005938;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoskeleton#GO:0005856;apical junction complex#GO:0043296;apical part of cell#GO:0045177;membraneless organelle#GO:0043228;cell junction#GO:0030054;adherens junction#GO:0005912;cell-cell junction#GO:0005911;membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane region#GO:0098590;cortical actin cytoskeleton#GO:0030864;cytoplasm#GO:0005737;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=22422|UniProtKB=Q7Z4H9 Q7Z4H9 FAM220A PTHR31980:SF3 PROTEIN FAM220A PROTEIN FAM220A intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=26741|UniProtKB=Q5XG92 Q5XG92 CES4A PTHR11559:SF254 CARBOXYLESTERASE CARBOXYLESTERASE 4A hydrolase activity#GO:0016787;catalytic activity#GO:0003824;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788 esterase#PC00097 HUMAN|HGNC=11185|UniProtKB=Q92673 Q92673 SORL1 PTHR12106:SF50 SORTILIN RELATED SORTILIN-RELATED RECEPTOR protein localization to lysosome#GO:0061462;establishment of protein localization to vacuole#GO:0072666;protein targeting#GO:0006605;protein localization to organelle#GO:0033365;lysosomal transport#GO:0007041;protein localization to vacuole#GO:0072665;post-Golgi vesicle-mediated transport#GO:0006892;protein transport#GO:0015031;localization#GO:0051179;cellular localization#GO:0051641;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule localization#GO:0033036;protein targeting to vacuole#GO:0006623;vesicle-mediated transport#GO:0016192;vacuolar transport#GO:0007034;transport#GO:0006810;intracellular protein transport#GO:0006886;Golgi vesicle transport#GO:0048193;protein localization to Golgi apparatus#GO:0034067;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794 membrane traffic protein#PC00150 HUMAN|HGNC=30400|UniProtKB=Q9NS98 Q9NS98 SEMA3G PTHR11036:SF20 SEMAPHORIN SEMAPHORIN-3G signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;signaling receptor binding#GO:0005102;binding#GO:0005488;molecular function activator activity#GO:0140677;protein binding#GO:0005515 regulation of cell migration#GO:0030334;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;positive regulation of locomotion#GO:0040017;neuron projection guidance#GO:0097485;response to external stimulus#GO:0009605;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;positive regulation of cellular process#GO:0048522;positive regulation of cell migration#GO:0030335;axon guidance#GO:0007411;axon development#GO:0061564;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;regulation of locomotion#GO:0040012;multicellular organismal process#GO:0032501;chemotaxis#GO:0006935;system development#GO:0048731;cell communication#GO:0007154;regulation of cell motility#GO:2000145;anatomical structure development#GO:0048856;cellular response to stimulus#GO:0051716;locomotion#GO:0040011;regulation of cellular process#GO:0050794;neuron differentiation#GO:0030182;cell surface receptor signaling pathway#GO:0007166;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell projection morphogenesis#GO:0048858;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;neuron projection development#GO:0031175;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;response to chemical#GO:0042221;taxis#GO:0042330;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;neuron development#GO:0048666;axonogenesis#GO:0007409;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;positive regulation of cell motility#GO:2000147;cellular component organization#GO:0016043;signaling#GO:0023052;cell development#GO:0048468;response to stimulus#GO:0050896;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell morphogenesis#GO:0000902 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 membrane-bound signaling molecule#PC00152 HUMAN|HGNC=30532|UniProtKB=Q9BT25 Q9BT25 HAUS8 PTHR31807:SF37 AUGMIN FAMILY MEMBER HAUS AUGMIN-LIKE COMPLEX SUBUNIT 8 HUMAN|HGNC=16849|UniProtKB=Q15014 Q15014 MORF4L2 PTHR10880:SF25 MORTALITY FACTOR 4-LIKE PROTEIN MORTALITY FACTOR 4-LIKE PROTEIN 2 chromatin binding#GO:0003682;binding#GO:0005488 regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 membraneless organelle#GO:0043228;intracellular protein-containing complex#GO:0140535;histone acetyltransferase complex#GO:0000123;transferase complex#GO:1990234;H4 histone acetyltransferase complex#GO:1902562;protein-containing complex#GO:0032991;NuA4 histone acetyltransferase complex#GO:0035267;intracellular membraneless organelle#GO:0043232;chromatin#GO:0000785;intracellular anatomical structure#GO:0005622;acetyltransferase complex#GO:1902493;protein acetyltransferase complex#GO:0031248;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;chromosome#GO:0005694 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=12886|UniProtKB=Q9H2Y7 Q9H2Y7 ZNF106 PTHR14435:SF2 ZINC FINGER PROTEIN 106 ZINC FINGER PROTEIN 106 HUMAN|HGNC=32153|UniProtKB=A6NM43 A6NM43 CCT8L1P PTHR11353:SF100 CHAPERONIN T-COMPLEX PROTEIN 1 SUBUNIT THETA-LIKE 1-RELATED protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;protein folding#GO:0006457;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152 protein folding chaperone complex#GO:0101031;chaperonin-containing T-complex#GO:0005832;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;cytosol#GO:0005829;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737 chaperonin#PC00073 HUMAN|HGNC=16253|UniProtKB=Q9NUV7 Q9NUV7 SPTLC3 PTHR13693:SF56 CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE SERINE PALMITOYLTRANSFERASE 3 acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;palmitoyltransferase activity#GO:0016409;acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824 biosynthetic process#GO:0009058;small molecule metabolic process#GO:0044281;lipid biosynthetic process#GO:0008610;alcohol biosynthetic process#GO:0046165;cellular process#GO:0009987;primary metabolic process#GO:0044238;sphingoid biosynthetic process#GO:0046520;ceramide metabolic process#GO:0006672;ceramide biosynthetic process#GO:0046513;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152;sphingolipid metabolic process#GO:0006665;alcohol metabolic process#GO:0006066;sphingolipid biosynthetic process#GO:0030148 protein-containing complex#GO:0032991;transferase complex#GO:1990234;catalytic complex#GO:1902494 transaminase#PC00216 HUMAN|HGNC=13802|UniProtKB=Q9HD90 Q9HD90 NEUROD4 PTHR19290:SF86 BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED NEUROGENIC DIFFERENTIATION FACTOR 4 transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 sensory organ development#GO:0007423;developmental process#GO:0032502;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;axon development#GO:0061564;positive regulation of cellular process#GO:0048522;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;plasma membrane bounded cell projection organization#GO:0120036;camera-type eye development#GO:0043010;positive regulation of biosynthetic process#GO:0009891;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;visual system development#GO:0150063;positive regulation of RNA metabolic process#GO:0051254;positive regulation of transcription by RNA polymerase II#GO:0045944;neuron differentiation#GO:0030182;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;animal organ development#GO:0048513;neuron projection development#GO:0031175;sensory system development#GO:0048880;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;nervous system development#GO:0007399;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;neuron development#GO:0048666;eye development#GO:0001654;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;cell projection organization#GO:0030030;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;cell development#GO:0048468 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=10498|UniProtKB=P05109 P05109 S100A8 PTHR11639:SF5 S100 CALCIUM-BINDING PROTEIN PROTEIN S100-A8 protein binding#GO:0005515;metal ion binding#GO:0046872;cation binding#GO:0043169;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;calcium ion binding#GO:0005509 neutrophil chemotaxis#GO:0030593;response to lipopolysaccharide#GO:0032496;response to stress#GO:0006950;cell-cell adhesion#GO:0098609;response to biotic stimulus#GO:0009607;cellular process#GO:0009987;leukocyte cell-cell adhesion#GO:0007159;granulocyte migration#GO:0097530;response to lipid#GO:0033993;taxis#GO:0042330;neutrophil migration#GO:1990266;response to chemical#GO:0042221;cellular response to chemical stimulus#GO:0070887;immune system process#GO:0002376;cell adhesion#GO:0007155;response to oxygen-containing compound#GO:1901700;response to molecule of bacterial origin#GO:0002237;response to stimulus#GO:0050896;granulocyte chemotaxis#GO:0071621;biological process involved in interspecies interaction between organisms#GO:0044419;leukocyte migration#GO:0050900;defense response#GO:0006952;leukocyte chemotaxis#GO:0030595;response to external stimulus#GO:0009605;myeloid leukocyte migration#GO:0097529;cell migration#GO:0016477;endothelial cell migration#GO:0043542;response to other organism#GO:0051707;response to bacterium#GO:0009617;inflammatory response#GO:0006954;chemotaxis#GO:0006935;cell chemotaxis#GO:0060326;cellular response to stimulus#GO:0051716;cell motility#GO:0048870;locomotion#GO:0040011;response to external biotic stimulus#GO:0043207 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 calcium-binding protein#PC00060;calmodulin-related#PC00061 HUMAN|HGNC=25130|UniProtKB=Q96HH4 Q96HH4 TMEM169 PTHR31777:SF0 TRANSMEMBRANE PROTEIN 169 TRANSMEMBRANE PROTEIN 169 HUMAN|HGNC=1607|UniProtKB=P51684 P51684 CCR6 PTHR10489:SF611 CELL ADHESION MOLECULE C-C CHEMOKINE RECEPTOR TYPE 6 cytokine binding#GO:0019955;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;immune receptor activity#GO:0140375;cytokine receptor activity#GO:0004896;molecular transducer activity#GO:0060089;protein binding#GO:0005515;transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488 intracellular signal transduction#GO:0035556;cell chemotaxis#GO:0060326;positive regulation of chemotaxis#GO:0050921;cell communication#GO:0007154;regulation of cell motility#GO:2000145;chemotaxis#GO:0006935;locomotion#GO:0040011;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;cell motility#GO:0048870;regulation of leukocyte migration#GO:0002685;cellular response to stimulus#GO:0051716;calcium-mediated signaling#GO:0019722;positive regulation of locomotion#GO:0040017;response to external stimulus#GO:0009605;regulation of response to stimulus#GO:0048583;regulation of cell migration#GO:0030334;leukocyte migration#GO:0050900;regulation of locomotion#GO:0040012;biological regulation#GO:0065007;cell migration#GO:0016477;positive regulation of response to stimulus#GO:0048584;positive regulation of cell migration#GO:0030335;positive regulation of cellular process#GO:0048522;immune response#GO:0006955;regulation of biological quality#GO:0065008;mononuclear cell migration#GO:0071674;immune system process#GO:0002376;cellular response to chemical stimulus#GO:0070887;positive regulation of cytosolic calcium ion concentration#GO:0007204;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;regulation of chemotaxis#GO:0050920;positive regulation of cell motility#GO:2000147;positive regulation of response to external stimulus#GO:0032103;intracellular signaling cassette#GO:0141124;regulation of response to external stimulus#GO:0032101;taxis#GO:0042330;response to chemical#GO:0042221;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of immune system process#GO:0002684;lymphocyte migration#GO:0072676 membrane#GO:0016020;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;plasma membrane#GO:0005886 cell adhesion molecule#PC00069 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CHKR#P00854 HUMAN|HGNC=12658|UniProtKB=P52735 P52735 VAV2 PTHR45818:SF4 PROTEIN VAV GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV2 enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 regulation of immune response#GO:0050776;regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051896;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;cell motility#GO:0048870;regulation of immune system process#GO:0002682;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;positive regulation of cellular process#GO:0048522;small GTPase-mediated signal transduction#GO:0007264;immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of response to stimulus#GO:0048584;cell migration#GO:0016477;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;positive regulation of signaling#GO:0023056;regulation of biological process#GO:0050789;immune response-regulating signaling pathway#GO:0002764;signaling#GO:0023052;response to stimulus#GO:0050896;positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051897;cell surface receptor signaling pathway#GO:0007166;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;intracellular signaling cassette#GO:0141124 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 B cell activation#P00010>vav#P00368;T cell activation#P00053>vav#P01295;PDGF signaling pathway#P00047>Vav#P01169 HUMAN|HGNC=23384|UniProtKB=Q8TF39 Q8TF39 ZNF483 PTHR24377:SF425 IP01015P-RELATED ZINC FINGER PROTEIN 483 RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=19959|UniProtKB=Q9Y4F4 Q9Y4F4 TOGARAM1 PTHR21567:SF6 CLASP TOG ARRAY REGULATOR OF AXONEMAL MICROTUBULES PROTEIN 1 binding#GO:0005488;microtubule binding#GO:0008017;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515 cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;cytoskeleton organization#GO:0007010;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226 supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cytoskeleton#GO:0005856;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cytoplasmic microtubule#GO:0005881;microtubule#GO:0005874;membrane-bounded organelle#GO:0043227;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;cilium#GO:0005929;intracellular organelle#GO:0043229 microtubule or microtubule-binding cytoskeletal protein#PC00157;cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HUMAN|HGNC=21610|UniProtKB=Q9C0E8 Q9C0E8 LNPK PTHR22166:SF12 ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;endoplasmic reticulum organization#GO:0007029;endoplasmic reticulum tubular network organization#GO:0071786;cellular component organization or biogenesis#GO:0071840;endomembrane system organization#GO:0010256 intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;endoplasmic reticulum tubular network#GO:0071782;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 HUMAN|HGNC=18688|UniProtKB=Q5IJ48 Q5IJ48 CRB2 PTHR24049:SF19 CRUMBS FAMILY MEMBER PROTEIN CRUMBS HOMOLOG 2 heterophilic cell-cell adhesion#GO:0007157;cellular process#GO:0009987;cell-cell adhesion#GO:0098609;establishment or maintenance of epithelial cell apical/basal polarity#GO:0045197;cell adhesion#GO:0007155;establishment or maintenance of bipolar cell polarity#GO:0061245;establishment or maintenance of cell polarity#GO:0007163;establishment or maintenance of apical/basal cell polarity#GO:0035088 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cell adhesion molecule#PC00069 HUMAN|HGNC=22785|UniProtKB=A8MUV8 A8MUV8 ZNF727 PTHR24384:SF206 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED ZINC FINGER PROTEIN 727 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 DNA-binding transcription factor#PC00218 HUMAN|HGNC=6293|UniProtKB=O15554 O15554 KCNN4 PTHR10153:SF41 SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL INTERMEDIATE CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL PROTEIN 4 protein binding#GO:0005515;monoatomic cation transmembrane transporter activity#GO:0008324;binding#GO:0005488;gated channel activity#GO:0022836;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;calmodulin binding#GO:0005516;transporter activity#GO:0005215;potassium ion transmembrane transporter activity#GO:0015079;calcium-activated cation channel activity#GO:0005227;channel activity#GO:0015267;potassium channel activity#GO:0005267;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation channel activity#GO:0005261;monoatomic ion-gated channel activity#GO:0022839;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;calcium-activated potassium channel activity#GO:0015269;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857 monoatomic ion transport#GO:0006811;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;transport#GO:0006810;monoatomic ion transmembrane transport#GO:0034220;potassium ion transmembrane transport#GO:0071805;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813;cellular process#GO:0009987 membrane#GO:0016020;cell body#GO:0044297;neuron projection#GO:0043005;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;neuronal cell body#GO:0043025;plasma membrane bounded cell projection#GO:0120025 ion channel#PC00133;voltage-gated ion channel#PC00241 HUMAN|HGNC=25722|UniProtKB=Q8WTP8 Q8WTP8 AEN PTHR12801:SF57 RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED APOPTOSIS-ENHANCING NUCLEASE exonuclease activity#GO:0004527;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;nuclease activity#GO:0004518 biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;apoptotic signaling pathway#GO:0097190;DNA damage response#GO:0006974;regulation of cellular process#GO:0050794;RNA biosynthetic process#GO:0032774;intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator#GO:0042771;nucleic acid metabolic process#GO:0090304;programmed cell death#GO:0012501;primary metabolic process#GO:0044238;cell death#GO:0008219;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;gene expression#GO:0010467;RNA processing#GO:0006396;intrinsic apoptotic signaling pathway in response to DNA damage#GO:0008630;response to stress#GO:0006950;signal transduction#GO:0007165;cellular process#GO:0009987;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;response to stimulus#GO:0050896;intrinsic apoptotic signaling pathway by p53 class mediator#GO:0072332;signaling#GO:0023052;regulation of biological process#GO:0050789;apoptotic process#GO:0006915;RNA metabolic process#GO:0016070;intrinsic apoptotic signaling pathway#GO:0097193;signal transduction by p53 class mediator#GO:0072331;nucleic acid biosynthetic process#GO:0141187;cellular response to stress#GO:0033554 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031;exoribonuclease#PC00099 HUMAN|HGNC=17110|UniProtKB=Q8TE60 Q8TE60 ADAMTS18 PTHR13723:SF167 ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 18 metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 cellular component organization#GO:0016043;primary metabolic process#GO:0044238;cellular process#GO:0009987;metabolic process#GO:0008152;proteolysis#GO:0006508;extracellular structure organization#GO:0043062;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;protein metabolic process#GO:0019538;extracellular matrix organization#GO:0030198;external encapsulating structure organization#GO:0045229 cellular anatomical structure#GO:0110165;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576 metalloprotease#PC00153 HUMAN|HGNC=26927|UniProtKB=Q96CU9 Q96CU9 FOXRED1 PTHR13847:SF294 SARCOSINE DEHYDROGENASE-RELATED FAD-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 1 cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;NADH dehydrogenase complex assembly#GO:0010257;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;mitochondrial respiratory chain complex I assembly#GO:0032981;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;cellular component assembly#GO:0022607;mitochondrial respiratory chain complex assembly#GO:0033108;mitochondrion organization#GO:0007005 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 dehydrogenase#PC00092 HUMAN|HGNC=24740|UniProtKB=Q8N8J6 Q8N8J6 ZNF615 PTHR24376:SF194 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 615 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=3670|UniProtKB=Q92913 Q92913 FGF13 PTHR11486:SF77 FIBROBLAST GROWTH FACTOR FIBROBLAST GROWTH FACTOR 13 transporter regulator activity#GO:0141108;binding#GO:0005488;signaling receptor binding#GO:0005102;molecular function activator activity#GO:0140677;channel regulator activity#GO:0016247;protein binding#GO:0005515;growth factor receptor binding#GO:0070851;receptor ligand activity#GO:0048018;growth factor activity#GO:0008083;ion channel regulator activity#GO:0099106;signaling receptor regulator activity#GO:0030545;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;fibroblast growth factor receptor binding#GO:0005104 cellular response to growth factor stimulus#GO:0071363;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;animal gross anatomical part developmental process#GO:0160108;signaling#GO:0023052;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;cell differentiation#GO:0030154;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;positive regulation of cell population proliferation#GO:0008284;multicellular organism development#GO:0007275;cell surface receptor signaling pathway#GO:0007166;regulation of MAPK cascade#GO:0043408;nervous system development#GO:0007399;cellular response to fibroblast growth factor stimulus#GO:0044344;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;system development#GO:0048731;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;cell communication#GO:0007154;regulation of cell motility#GO:2000145;regulation of cell population proliferation#GO:0042127;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;response to growth factor#GO:0070848;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;positive regulation of MAPK cascade#GO:0043410;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;developmental process#GO:0032502;regulation of cell migration#GO:0030334;response to fibroblast growth factor#GO:0071774;regulation of locomotion#GO:0040012;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;multicellular organismal process#GO:0032501;fibroblast growth factor receptor signaling pathway#GO:0008543;positive regulation of response to stimulus#GO:0048584;positive regulation of cellular process#GO:0048522 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;extracellular region#GO:0005576;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 growth factor#PC00112;intercellular signal molecule#PC00207 FGF signaling pathway#P00021>FGF#P00623 HUMAN|HGNC=17615|UniProtKB=Q9BSM1 Q9BSM1 PCGF1 PTHR10825:SF29 RING FINGER DOMAIN-CONTAINING, POLYCOMB GROUP COMPONENT POLYCOMB GROUP RING FINGER PROTEIN 1 chromatin binding#GO:0003682;binding#GO:0005488 negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523 ubiquitin ligase complex#GO:0000151;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear ubiquitin ligase complex#GO:0000152;intracellular membrane-bounded organelle#GO:0043231;nuclear protein-containing complex#GO:0140513;PRC1 complex#GO:0035102;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;protein-containing complex#GO:0032991;PcG protein complex#GO:0031519;nucleus#GO:0005634 histone modifying enzyme#PC00261 HUMAN|HGNC=1122|UniProtKB=P43251 P43251 BTD PTHR10609:SF14 BIOTINIDASE-RELATED BIOTINIDASE hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810 metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;cellular process#GO:0009987;biotin metabolic process#GO:0006768;sulfur compound metabolic process#GO:0006790;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;small molecule metabolic process#GO:0044281 hydrolase#PC00121 HUMAN|HGNC=3007|UniProtKB=Q9P2X0 Q9P2X0 DPM3 PTHR16433:SF0 DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 3 DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 3 biosynthetic process#GO:0009058;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152 mannosyltransferase complex#GO:0031501;membrane#GO:0016020;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;endoplasmic reticulum membrane#GO:0005789;transferase complex#GO:1990234;endoplasmic reticulum#GO:0005783;intracellular protein-containing complex#GO:0140535;organelle membrane#GO:0031090;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622 transferase#PC00220 HUMAN|HGNC=11467|UniProtKB=P63272 P63272 SUPT4H1 PTHR12882:SF1 SUPPRESSOR OF TY 4 TRANSCRIPTION ELONGATION FACTOR SPT4 enzyme binding#GO:0019899;RNA polymerase binding#GO:0070063;binding#GO:0005488;RNA polymerase core enzyme binding#GO:0043175;RNA polymerase II complex binding#GO:0000993;protein binding#GO:0005515 gene expression#GO:0010467;transcription elongation by RNA polymerase II#GO:0006368;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;DNA-templated transcription elongation#GO:0006354;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;transcription by RNA polymerase II#GO:0006366;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187 organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;nucleoplasm#GO:0005654;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;transcription elongation factor complex#GO:0008023;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 general transcription factor#PC00259;RNA metabolism protein#PC00031 HUMAN|HGNC=17663|UniProtKB=Q5JRX3 Q5JRX3 PITRM1 PTHR43016:SF18 PRESEQUENCE PROTEASE PRESEQUENCE PROTEASE, MITOCHONDRIAL hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metalloendopeptidase activity#GO:0004222;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;cellular process#GO:0009987;catabolic process#GO:0009056 intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 HUMAN|HGNC=31796|UniProtKB=Q5QJ38 Q5QJ38 TCHHL1 PTHR47612:SF1 TRICHOHYALIN-LIKE PROTEIN 1 TRICHOHYALIN-LIKE PROTEIN 1 HUMAN|HGNC=6308|UniProtKB=P23276 P23276 KEL PTHR11733:SF128 ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED KELL BLOOD GROUP GLYCOPROTEIN catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 protein processing#GO:0016485;cellular process#GO:0009987;peptide hormone processing#GO:0016486;macromolecule biosynthetic process#GO:0009059;hormone metabolic process#GO:0042445;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;biological regulation#GO:0065007;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;regulation of hormone levels#GO:0010817;proteolysis#GO:0006508;signaling receptor ligand precursor processing#GO:0140448;protein metabolic process#GO:0019538;regulation of biological quality#GO:0065008 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 protease#PC00190;metalloprotease#PC00153 HUMAN|HGNC=3690|UniProtKB=P22607 P22607 FGFR3 PTHR24416:SF505 TYROSINE-PROTEIN KINASE RECEPTOR FIBROBLAST GROWTH FACTOR RECEPTOR 3 transferase activity#GO:0016740;kinase activity#GO:0016301;signaling receptor activity#GO:0038023;fibroblast growth factor binding#GO:0017134;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888;phosphotransferase activity, alcohol group as acceptor#GO:0016773;growth factor binding#GO:0019838;protein binding#GO:0005515;protein kinase activity#GO:0004672;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;transmembrane receptor protein kinase activity#GO:0019199;molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714 cell surface receptor signaling pathway#GO:0007166;regulation of MAPK cascade#GO:0043408;cellular response to fibroblast growth factor stimulus#GO:0044344;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;cellular response to growth factor stimulus#GO:0071363;positive regulation of signaling#GO:0023056;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;positive regulation of cell population proliferation#GO:0008284;signaling#GO:0023052;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;response to fibroblast growth factor#GO:0071774;positive regulation of MAPK cascade#GO:0043410;positive regulation of cellular process#GO:0048522;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;fibroblast growth factor receptor signaling pathway#GO:0008543;positive regulation of response to stimulus#GO:0048584;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;response to growth factor#GO:0070848 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;signaling receptor complex#GO:0043235 transmembrane signal receptor#PC00197 FGF signaling pathway#P00021>FGFR1-4#P00636 HUMAN|HGNC=13652|UniProtKB=A6H8Y1 A6H8Y1 BDP1 PTHR22929:SF0 RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR B TRANSCRIPTION FACTOR TFIIIB COMPONENT B'' HOMOLOG RNA metabolism protein#PC00031;general transcription factor#PC00259 HUMAN|HGNC=13149|UniProtKB=P36508 P36508 ZNF76 PTHR19818:SF151 ZINC FINGER PROTEIN ZIC AND GLI ZINC FINGER PROTEIN 76 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=19201|UniProtKB=A6NC42 A6NC42 DPPA5 PTHR31368:SF4 DEVELOPMENT PLURPOTENCY-ASSOCIATED PROTEIN 1/5 FAMILY MEMBER DEVELOPMENTAL PLURIPOTENCY-ASSOCIATED 5 PROTEIN mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=19698|UniProtKB=Q8TDN2 Q8TDN2 KCNV2 PTHR11537:SF40 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY V MEMBER 2 ion channel regulator activity#GO:0099106;transporter regulator activity#GO:0141108;potassium channel regulator activity#GO:0015459;molecular function regulator activity#GO:0098772;channel regulator activity#GO:0016247 establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;transport#GO:0006810;monoatomic cation transmembrane transport#GO:0098655;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;metal ion transport#GO:0030001;action potential#GO:0001508 cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;cation channel complex#GO:0034703;voltage-gated potassium channel complex#GO:0008076;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351 voltage-gated ion channel#PC00241;ion channel#PC00133 HUMAN|HGNC=30278|UniProtKB=Q14699 Q14699 RFTN1 PTHR17601:SF3 RAFTLIN-RELATED RAFTLIN HUMAN|HGNC=6902|UniProtKB=O00187 O00187 MASP2 PTHR24255:SF10 COMPLEMENT COMPONENT 1, S SUBCOMPONENT-RELATED MANNAN-BINDING LECTIN SERINE PROTEASE 2 hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;serine-type peptidase activity#GO:0008236;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity#GO:0003824 defense response#GO:0006952;response to external stimulus#GO:0009605;innate immune response#GO:0045087;immune effector process#GO:0002252;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;humoral immune response#GO:0006959;response to other organism#GO:0051707;biological regulation#GO:0065007;defense response to other organism#GO:0098542;positive regulation of response to stimulus#GO:0048584;positive regulation of biological process#GO:0048518;immune response#GO:0006955;defense response to symbiont#GO:0140546;activation of immune response#GO:0002253;complement activation#GO:0006956;response to stress#GO:0006950;positive regulation of immune system process#GO:0002684;response to biotic stimulus#GO:0009607;regulation of immune response#GO:0050776;immune system process#GO:0002376;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;regulation of immune system process#GO:0002682;response to stimulus#GO:0050896;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 serine protease#PC00203 HUMAN|HGNC=24932|UniProtKB=Q9NZ63 Q9NZ63 C9orf78 PTHR13486:SF2 TELOMERE LENGTH AND SILENCING PROTEIN 1 TLS1 FAMILY MEMBER SPLICING FACTOR C9ORF78 RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139 ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;spliceosomal complex#GO:0005681;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=9456|UniProtKB=P07225 P07225 PROS1 PTHR24040:SF0 LAMININ G-LIKE DOMAIN-CONTAINING PROTEIN VITAMIN K-DEPENDENT PROTEIN S negative regulation of coagulation#GO:0050819;regulation of coagulation#GO:0050818;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;negative regulation of biological process#GO:0048519;negative regulation of multicellular organismal process#GO:0051241;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 Blood coagulation#P00011>PS#P00412 HUMAN|HGNC=78|UniProtKB=O14639 O14639 ABLIM1 PTHR24213:SF18 ACTIN-BINDING LIM PROTEIN ACTIN-BINDING LIM PROTEIN 1 protein-containing complex binding#GO:0044877;protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;actin filament binding#GO:0051015;binding#GO:0005488 organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031;cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782;cilium assembly#GO:0060271;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cell projection assembly#GO:0030031;lamellipodium assembly#GO:0030032;cellular component assembly#GO:0022607;cell projection organization#GO:0030030;plasma membrane bounded cell projection organization#GO:0120036 cytoskeleton#GO:0005856;stress fiber#GO:0001725;intracellular organelle#GO:0043229;actin filament bundle#GO:0032432;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;actin cytoskeleton#GO:0015629;actomyosin#GO:0042641;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 Axon guidance mediated by netrin#P00009>Ablim#P00358 HUMAN|HGNC=25737|UniProtKB=Q9H9Q4 Q9H9Q4 NHEJ1 PTHR32235:SF1 NON-HOMOLOGOUS END-JOINING FACTOR 1 NON-HOMOLOGOUS END-JOINING FACTOR 1 DNA binding#GO:0003677;nucleic acid binding#GO:0003676;binding#GO:0005488 cellular response to stress#GO:0033554;DNA damage response#GO:0006974;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;double-strand break repair#GO:0006302;double-strand break repair via nonhomologous end joining#GO:0006303;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;primary metabolic process#GO:0044238;nucleobase-containing compound metabolic process#GO:0006139;response to stimulus#GO:0050896 intracellular membrane-bounded organelle#GO:0043231;nonhomologous end joining complex#GO:0070419;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634;DNA repair complex#GO:1990391;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 HUMAN|HGNC=5974|UniProtKB=P78552 P78552 IL13RA1 PTHR23036:SF89 CYTOKINE RECEPTOR INTERLEUKIN-13 RECEPTOR SUBUNIT ALPHA-1 cytokine binding#GO:0019955;signaling receptor activity#GO:0038023;immune receptor activity#GO:0140375;cytokine receptor activity#GO:0004896;molecular transducer activity#GO:0060089;protein binding#GO:0005515;transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to cytokine stimulus#GO:0071345;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to chemical#GO:0042221;response to stimulus#GO:0050896;response to cytokine#GO:0034097;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;cytokine-mediated signaling pathway#GO:0019221;cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;response to peptide#GO:1901652 plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;signaling receptor complex#GO:0043235;membrane#GO:0016020 transmembrane signal receptor#PC00197 Interleukin signaling pathway#P00036>Receptor subunit alpha#P00992 HUMAN|HGNC=19765|UniProtKB=Q8WXK3 Q8WXK3 ASB13 PTHR24173:SF44 ANKYRIN REPEAT CONTAINING ANKYRIN REPEAT AND SOCS BOX PROTEIN 13 scaffold/adaptor protein#PC00226 HUMAN|HGNC=28105|UniProtKB=Q96PB8 Q96PB8 LRRC3B PTHR24373:SF276 SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN LEUCINE-RICH REPEAT-CONTAINING PROTEIN 3B molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=34360|UniProtKB=Q6ZNW5 Q6ZNW5 GDPGP1 PTHR20884:SF8 GDP-D-GLUCOSE PHOSPHORYLASE 1 GDP-D-GLUCOSE PHOSPHORYLASE 1 transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;nucleotidyltransferase activity#GO:0016779 glucose metabolic process#GO:0006006;monosaccharide metabolic process#GO:0005996;metabolic process#GO:0008152;carbohydrate metabolic process#GO:0005975;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;cellular process#GO:0009987;response to stress#GO:0006950;hexose metabolic process#GO:0019318;primary metabolic process#GO:0044238 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=18876|UniProtKB=P59539 P59539 TAS2R45 PTHR11394:SF134 TASTE RECEPTOR TYPE 2 TASTE RECEPTOR TYPE 2 MEMBER 45 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;bitter taste receptor activity#GO:0033038;taste receptor activity#GO:0008527;signaling receptor activity#GO:0038023 response to stimulus#GO:0050896;response to chemical#GO:0042221;multicellular organismal process#GO:0032501;sensory perception of bitter taste#GO:0050913;detection of chemical stimulus#GO:0009593;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;system process#GO:0003008;detection of chemical stimulus involved in sensory perception of bitter taste#GO:0001580;sensory perception#GO:0007600;nervous system process#GO:0050877;detection of chemical stimulus involved in sensory perception of taste#GO:0050912;sensory perception of taste#GO:0050909;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606 cellular anatomical structure#GO:0110165;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=16646|UniProtKB=O60575 O60575 SPINK4 PTHR21179:SF0 SERINE-TYPE ENDOPEPTIDASE INHIBITOR SERINE PROTEASE INHIBITOR KAZAL-TYPE 4 protease inhibitor#PC00191 HUMAN|HGNC=18708|UniProtKB=Q9Y3R0 Q9Y3R0 GRIP1 PTHR46227:SF3 GLUTAMATE RECEPTOR-INTERACTING PROTEIN GRIP GLUTAMATE RECEPTOR-INTERACTING PROTEIN 1 intracellular transport#GO:0046907;regulation of postsynaptic membrane neurotransmitter receptor levels#GO:0099072;protein localization to cell periphery#GO:1990778;intracellular protein transport#GO:0006886;transport#GO:0006810;establishment of localization#GO:0051234;protein localization to synapse#GO:0035418;neurotransmitter receptor transport to postsynaptic membrane#GO:0098969;endosomal transport#GO:0016197;intracellular protein localization#GO:0008104;vesicle-mediated transport to the plasma membrane#GO:0098876;macromolecule localization#GO:0033036;establishment of protein localization to membrane#GO:0090150;endosome to plasma membrane protein transport#GO:0099638;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;vesicle-mediated transport#GO:0016192;biological regulation#GO:0065007;protein localization to cell junction#GO:1902414;establishment of protein localization to plasma membrane#GO:0061951;localization within membrane#GO:0051668;cellular localization#GO:0051641;localization#GO:0051179;protein transport#GO:0015031;regulation of biological quality#GO:0065008;protein localization to plasma membrane#GO:0072659;protein localization to membrane#GO:0072657;endocytic recycling#GO:0032456 HUMAN|HGNC=4396|UniProtKB=P62873 P62873 GNB1 PTHR19850:SF29 GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)_G(S)_G(T) SUBUNIT BETA-1 signaling adaptor activity#GO:0035591;signaling receptor complex adaptor activity#GO:0030159;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 cytoplasmic side of plasma membrane#GO:0009898;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cellular anatomical structure#GO:0110165;extrinsic component of cytoplasmic side of plasma membrane#GO:0031234;catalytic complex#GO:1902494;side of membrane#GO:0098552;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;cell periphery#GO:0071944;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cytoplasmic side of membrane#GO:0098562;extrinsic component of plasma membrane#GO:0019897;extrinsic component of membrane#GO:0019898 protein-binding activity modulator#PC00095;G-protein#PC00020;heterotrimeric G-protein#PC00117 Nicotine pharmacodynamics pathway#P06587>GNB#P06591;5HT1 type receptor mediated signaling pathway#P04373>G-protein#P04408;Endogenous cannabinoid signaling#P05730>Gbeta#P05745;Histamine H2 receptor mediated signaling pathway#P04386>G-Protein#P04490;Beta2 adrenergic receptor signaling pathway#P04378>G-Protein#P04443;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GIRK#P00743;Opioid prodynorphin pathway#P05916>G-protein#P06002;Metabotropic glutamate receptor group II pathway#P00040>G-protein#P01047;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Gbeta#P00727;Oxytocin receptor mediated signaling pathway#P04391>G-Protein#P04534;Cortocotropin releasing factor receptor signaling pathway#P04380>G-Protein#P04458;Metabotropic glutamate receptor group III pathway#P00039>G-Protein#P01045;GABA-B receptor II signaling#P05731>Gbeta#P05755;Enkephalin release#P05913>G-Protein (s)#P05977;Gonadotropin-releasing hormone receptor pathway#P06664>Gbeta#P06769;Thyrotropin-releasing hormone receptor signaling pathway#P04394>G-Protein#P04584;5HT2 type receptor mediated signaling pathway#P04374>G-protein#P04416;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Gbeta#P00753;Dopamine receptor mediated signaling pathway#P05912>Gbeta#P05954;Opioid proenkephalin pathway#P05915>G-protein#P05994;Histamine H1 receptor mediated signaling pathway#P04385>G-Protein#P04488;PI3 kinase pathway#P00048>Gbetagamma#P01188;Beta3 adrenergic receptor signaling pathway#P04379>G-Protein#P04448;Beta1 adrenergic receptor signaling pathway#P04377>G-Protein#P04436;Wnt signaling pathway#P00057>GBeta#P01457;Angiotensin II-stimulated signaling through G proteins and beta-arrestin#P05911>Gbeta#P05930;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>G-Protein#P01085;5HT4 type receptor mediated signaling pathway#P04376>G-protein#P04430;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>G-Protein#P01073;Opioid proopiomelanocortin pathway#P05917>G-protein#P06012;CCKR signaling map#P06959>Gbeta/gamma#P07197;Enkephalin release#P05913>G-Protein (i)#P05974;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Gbeta#P00710 HUMAN|HGNC=19069|UniProtKB=Q9H227 Q9H227 GBA3 PTHR10353:SF291 GLYCOSYL HYDROLASE CYTOSOLIC BETA-GLUCOSIDASE hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;catalytic activity#GO:0003824;glucosidase activity#GO:0015926;beta-glucosidase activity#GO:0008422;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553 carbohydrate derivative catabolic process#GO:1901136;glycolipid metabolic process#GO:0006664;liposaccharide metabolic process#GO:1903509;catabolic process#GO:0009056;cellular process#GO:0009987;lipid catabolic process#GO:0016042;carbohydrate derivative metabolic process#GO:1901135;sphingolipid catabolic process#GO:0030149;primary metabolic process#GO:0044238;ceramide metabolic process#GO:0006672;lipid metabolic process#GO:0006629;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 hydrolase#PC00121;glycosidase#PC00110;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=2512|UniProtKB=Q9UBT7 Q9UBT7 CTNNAL1 PTHR46342:SF1 ALPHA-CATULIN ALPHA-CATULIN intracellular signal transduction#GO:0035556;Rho protein signal transduction#GO:0007266;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 Wnt signaling pathway#P00057>alpha-catenin#P01471 HUMAN|HGNC=18830|UniProtKB=Q5JT82 Q5JT82 KLF17 PTHR23235:SF159 KRUEPPEL-LIKE TRANSCRIPTION FACTOR KRUEPPEL-LIKE FACTOR 17 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=44160|UniProtKB=A6NCL2 A6NCL2 LRCOL1 PTHR10041:SF10 COLIPASE LEUCINE-RICH COLIPASE-LIKE PROTEIN 1 protein-binding activity modulator#PC00095 HUMAN|HGNC=23163|UniProtKB=Q8N2Z9 Q8N2Z9 CENPS PTHR22980:SF6 CORTISTATIN CENTROMERE PROTEIN S binding#GO:0005488;chromatin binding#GO:0003682 replication fork processing#GO:0031297;nucleobase-containing compound metabolic process#GO:0006139;organelle organization#GO:0006996;cellular process#GO:0009987;resolution of meiotic recombination intermediates#GO:0000712;meiotic nuclear division#GO:0140013;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;DNA metabolic process#GO:0006259;meiotic cell cycle#GO:0051321;metabolic process#GO:0008152;DNA recombination#GO:0006310;reproductive process#GO:0022414;homologous recombination#GO:0035825;meiosis I#GO:0007127;cellular component organization#GO:0016043;meiotic cell cycle process#GO:1903046;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cell cycle#GO:0007049;cell cycle process#GO:0022402;DNA replication#GO:0006260;reciprocal homologous recombination#GO:0140527;organelle fission#GO:0048285;DNA-templated DNA replication#GO:0006261;nuclear division#GO:0000280;meiosis I cell cycle process#GO:0061982;reciprocal meiotic recombination#GO:0007131;sexual reproduction#GO:0019953 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;Fanconi anaemia nuclear complex#GO:0043240 peptide hormone#PC00179;neuropeptide#PC00162 HUMAN|HGNC=19906|UniProtKB=O00398 O00398 P2RY10 PTHR24232:SF47 G-PROTEIN COUPLED RECEPTOR P2Y PURINOCEPTOR 10-RELATED transmembrane signaling receptor activity#GO:0004888;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=21569|UniProtKB=Q8N1K5 Q8N1K5 THEMIS PTHR15215:SF1 CABIT DOMAIN-CONTAINING PROTEIN PROTEIN THEMIS immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;antigen receptor-mediated signaling pathway#GO:0050851;activation of immune response#GO:0002253;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of immune system process#GO:0002684;immune response-activating signaling pathway#GO:0002757;positive regulation of immune response#GO:0050778;cell surface receptor signaling pathway#GO:0007166;regulation of response to stimulus#GO:0048583;T cell receptor signaling pathway#GO:0050852;signaling#GO:0023052;immune response-activating cell surface receptor signaling pathway#GO:0002429;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of biological process#GO:0050789;immune response-regulating signaling pathway#GO:0002764;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;regulation of immune response#GO:0050776;immune system process#GO:0002376 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=28855|UniProtKB=Q2M218 Q2M218 ZNF630 PTHR24377:SF216 IP01015P-RELATED ZINC FINGER PROTEIN 630 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=25468|UniProtKB=Q9H900 Q9H900 ZWILCH PTHR15995:SF1 PROTEIN ZWILCH HOMOLOG PROTEIN ZWILCH HOMOLOG negative regulation of mitotic sister chromatid separation#GO:2000816;negative regulation of mitotic cell cycle#GO:0045930;regulation of mitotic cell cycle phase transition#GO:1901990;cell cycle process#GO:0022402;regulation of organelle organization#GO:0033043;negative regulation of mitotic nuclear division#GO:0045839;regulation of biological process#GO:0050789;negative regulation of cell cycle phase transition#GO:1901988;negative regulation of biological process#GO:0048519;regulation of sister chromatid segregation#GO:0033045;signaling#GO:0023052;regulation of cell cycle#GO:0051726;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;negative regulation of metaphase/anaphase transition of cell cycle#GO:1902100;negative regulation of mitotic sister chromatid segregation#GO:0033048;regulation of chromosome segregation#GO:0051983;negative regulation of chromosome segregation#GO:0051985;negative regulation of cell cycle#GO:0045786;cellular process#GO:0009987;mitotic spindle assembly checkpoint signaling#GO:0007094;signal transduction#GO:0007165;negative regulation of sister chromatid segregation#GO:0033046;regulation of cell cycle process#GO:0010564;negative regulation of mitotic cell cycle phase transition#GO:1901991;cell cycle checkpoint signaling#GO:0000075;regulation of chromosome separation#GO:1905818;negative regulation of chromosome organization#GO:2001251;regulation of mitotic sister chromatid segregation#GO:0033047;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;localization#GO:0051179;negative regulation of mitotic metaphase/anaphase transition#GO:0045841;cellular response to stimulus#GO:0051716;negative regulation of organelle organization#GO:0010639;negative regulation of cellular component organization#GO:0051129;cell cycle#GO:0007049;regulation of cell cycle phase transition#GO:1901987;mitotic cell cycle checkpoint signaling#GO:0007093;regulation of cellular process#GO:0050794;protein localization to organelle#GO:0033365;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;mitotic cell cycle#GO:0000278;negative regulation of cell cycle process#GO:0010948;negative regulation of cellular process#GO:0048523;regulation of chromosome organization#GO:0033044;intracellular protein localization#GO:0008104;mitotic cell cycle process#GO:1903047;regulation of mitotic nuclear division#GO:0007088;negative regulation of chromosome separation#GO:1905819;regulation of mitotic sister chromatid separation#GO:0010965;regulation of mitotic cell cycle#GO:0007346;protein localization to kinetochore#GO:0034501;macromolecule localization#GO:0033036;regulation of nuclear division#GO:0051783;negative regulation of nuclear division#GO:0051784;biological regulation#GO:0065007;regulation of mitotic metaphase/anaphase transition#GO:0030071 chromosome#GO:0005694;condensed chromosome, centromeric region#GO:0000779;kinetochore#GO:0000776;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;supramolecular complex#GO:0099080;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;condensed chromosome#GO:0000793;chromosome, centromeric region#GO:0000775;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687 HUMAN|HGNC=10883|UniProtKB=Q14190 Q14190 SIM2 PTHR23043:SF19 HYPOXIA-INDUCIBLE FACTOR 1 ALPHA SINGLE-MINDED HOMOLOG 2 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=25081|UniProtKB=Q8IYS4 Q8IYS4 DNAAF8 PTHR35977:SF1 CHROMOSOME 16 OPEN READING FRAME 71 DYNEIN AXONEMAL ASSEMBLY FACTOR 8 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;membraneless organelle#GO:0043228;organelle#GO:0043226;intracellular organelle#GO:0043229 HUMAN|HGNC=1844|UniProtKB=Q9BXQ6 Q9BXQ6 TMEM121B PTHR47399:SF1 TRANSMEMBRANE PROTEIN 121B TRANSMEMBRANE PROTEIN 121B HUMAN|HGNC=8984|UniProtKB=Q9UBF8 Q9UBF8 PI4KB PTHR10048:SF122 PHOSPHATIDYLINOSITOL KINASE PHOSPHATIDYLINOSITOL 4-KINASE BETA kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphatidylinositol kinase activity#GO:0052742;catalytic activity#GO:0003824;transferase activity#GO:0016740;lipid kinase activity#GO:0001727;phosphotransferase activity, alcohol group as acceptor#GO:0016773 signaling#GO:0023052;glycerolipid metabolic process#GO:0046486;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;phosphorus metabolic process#GO:0006793;ear development#GO:0043583;phosphatidylinositol phosphate biosynthetic process#GO:0046854;animal gross anatomical part developmental process#GO:0160108;glycerophospholipid metabolic process#GO:0006650;signal transduction#GO:0007165;cellular process#GO:0009987;animal organ development#GO:0048513;metabolic process#GO:0008152;phospholipid metabolic process#GO:0006644;regulation of cellular process#GO:0050794;phospholipid biosynthetic process#GO:0008654;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;organophosphate biosynthetic process#GO:0090407;anatomical structure development#GO:0048856;biosynthetic process#GO:0009058;biological regulation#GO:0065007;lipid biosynthetic process#GO:0008610;glycerolipid biosynthetic process#GO:0045017;organophosphate metabolic process#GO:0019637;inner ear development#GO:0048839;glycerophospholipid biosynthetic process#GO:0046474;developmental process#GO:0032502;lipid metabolic process#GO:0006629;sensory organ development#GO:0007423 membrane#GO:0016020;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 kinase#PC00137 HUMAN|HGNC=15197|UniProtKB=Q8NH61 Q8NH61 OR51F2 PTHR26450:SF87 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 51F2 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=9553|UniProtKB=P62333 P62333 PSMC6 PTHR23073:SF179 26S PROTEASOME REGULATORY SUBUNIT 26S PROTEASOME REGULATORY SUBUNIT 10B isomerase activity#GO:0016853;ATP-dependent activity#GO:0140657;macromolecular conformation isomerase activity#GO:0120543;polypeptide conformation or assembly isomerase activity#GO:0120544;catalytic activity#GO:0003824 macromolecule catabolic process#GO:0009057;positive regulation of transcription by RNA polymerase II#GO:0045944;metabolic process#GO:0008152;proteasomal protein catabolic process#GO:0010498;positive regulation of cellular component biogenesis#GO:0044089;response to chemical#GO:0042221;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;response to stress#GO:0006950;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;positive regulation of cellular component organization#GO:0051130;regulation of cellular component biogenesis#GO:0044087;regulation of cellular component organization#GO:0051128;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;regulation of protein-containing complex assembly#GO:0043254;regulation of gene expression#GO:0010468;ubiquitin-dependent protein catabolic process#GO:0006511;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;ERAD pathway#GO:0036503;protein metabolic process#GO:0019538;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;response to endoplasmic reticulum stress#GO:0034976;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;cellular response to stimulus#GO:0051716;regulation of DNA-templated transcription initiation#GO:2000142;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238 catalytic complex#GO:1902494;endopeptidase complex#GO:1905369;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;proteasome complex#GO:0000502;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;peptidase complex#GO:1905368 protease#PC00190 HUMAN|HGNC=23399|UniProtKB=Q5H8C1 Q5H8C1 FREM1 PTHR45739:SF7 MATRIX PROTEIN, PUTATIVE-RELATED FRAS1-RELATED EXTRACELLULAR MATRIX PROTEIN 1 cellular process#GO:0009987;epithelial structure maintenance#GO:0010669;homeostatic process#GO:0042592;multicellular organismal process#GO:0032501;anatomical structure homeostasis#GO:0060249;cell-matrix adhesion#GO:0007160;cell adhesion#GO:0007155;tissue homeostasis#GO:0001894;multicellular organismal-level homeostasis#GO:0048871;cell-substrate adhesion#GO:0031589 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 HUMAN|HGNC=14053|UniProtKB=Q9NRX2 Q9NRX2 MRPL17 PTHR14413:SF24 RIBOSOMAL PROTEIN L17 LARGE RIBOSOMAL SUBUNIT PROTEIN BL17M structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 mitochondrial gene expression#GO:0140053;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;translation#GO:0006412;metabolic process#GO:0008152;biosynthetic process#GO:0009058;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;mitochondrial translation#GO:0032543;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238 organelle lumen#GO:0043233;mitochondrion#GO:0005739;ribosome#GO:0005840;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;large ribosomal subunit#GO:0015934;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;organellar ribosome#GO:0000313;intracellular anatomical structure#GO:0005622;mitochondrial ribosome#GO:0005761;membrane-enclosed lumen#GO:0031974;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;membraneless organelle#GO:0043228;mitochondrial large ribosomal subunit#GO:0005762 translational protein#PC00263;ribosomal protein#PC00202 HUMAN|HGNC=24353|UniProtKB=P0CG13 P0CG13 CHTF8 PTHR28605:SF3 CTF8, CHROMOSOME TRANSMISSION FIDELITY FACTOR 8 HOMOLOG (S. CEREVISIAE) CHROMOSOME TRANSMISSION FIDELITY PROTEIN 8 HOMOLOG regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;positive regulation of DNA metabolic process#GO:0051054;regulation of biological process#GO:0050789;regulation of DNA metabolic process#GO:0051052;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891 nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;nucleus#GO:0005634 HUMAN|HGNC=8886|UniProtKB=P0DJD7 P0DJD7 PGA4 PTHR47966:SF22 BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED PEPSIN A-3-RELATED endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;aspartic-type endopeptidase activity#GO:0004190;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;proteolysis#GO:0006508;primary metabolic process#GO:0044238;cellular process#GO:0009987 protease#PC00190;aspartic protease#PC00053 HUMAN|HGNC=18730|UniProtKB=Q96A08 Q96A08 H2BC1 PTHR23428:SF77 HISTONE H2B HISTONE H2B TYPE 1-A chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=30968|UniProtKB=A6NGK3 A6NGK3 GAGE10 PTHR14047:SF30 P ANTIGEN FAMILY MEMBER 5-RELATED G ANTIGEN 1-RELATED HUMAN|HGNC=19031|UniProtKB=Q8IZP1 Q8IZP1 TBC1D3 PTHR22957:SF571 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN TBC1 DOMAIN FAMILY MEMBER 3-RELATED GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047 GTPase-activating protein#PC00257;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HUMAN|HGNC=13436|UniProtKB=Q96KN7 Q96KN7 RPGRIP1 PTHR14240:SF3 RETINITIS PIGMENTOSA GTPASE REGULATOR-INTERACTING PROTEIN X-LINKED RETINITIS PIGMENTOSA GTPASE REGULATOR-INTERACTING PROTEIN 1 plasma membrane bounded cell projection organization#GO:0120036;cell projection organization#GO:0030030;cellular component assembly#GO:0022607;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component organization#GO:0016043;cilium assembly#GO:0060271;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cilium organization#GO:0044782;cellular component organization or biogenesis#GO:0071840;non-motile cilium assembly#GO:1905515;organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031 ciliary transition zone#GO:0035869;cilium#GO:0005929;membrane-bounded organelle#GO:0043227;non-motile cilium#GO:0097730;9+0 non-motile cilium#GO:0097731;neuron projection#GO:0043005;photoreceptor cell cilium#GO:0097733;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025 scaffold/adaptor protein#PC00226 HUMAN|HGNC=28303|UniProtKB=A5D8V7 A5D8V7 ODAD3 PTHR46518:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 151 OUTER DYNEIN ARM-DOCKING COMPLEX SUBUNIT 3 organelle assembly#GO:0070925;cilium movement#GO:0003341;microtubule bundle formation#GO:0001578;axonemal dynein complex assembly#GO:0070286;microtubule cytoskeleton organization#GO:0000226;axoneme assembly#GO:0035082;cilium organization#GO:0044782;cellular component organization#GO:0016043;cilium assembly#GO:0060271;protein-containing complex assembly#GO:0065003;cell projection organization#GO:0030030;microtubule-based movement#GO:0007018;plasma membrane bounded cell projection assembly#GO:0120031;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;protein-containing complex organization#GO:0043933;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cell projection assembly#GO:0030031;outer dynein arm assembly#GO:0036158;cellular process#GO:0009987;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection organization#GO:0120036 cytoskeleton#GO:0005856;ciliary basal body#GO:0036064;microtubule organizing center#GO:0005815;cilium#GO:0005929;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;microtubule cytoskeleton#GO:0015630;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995 HUMAN|HGNC=48778|UniProtKB=A0A2R8Y4L2 A0A2R8Y4L2 HNRNPA1L3 PTHR48026:SF31 HOMOLOGOUS TO DROSOPHILA SQD (SQUID) PROTEIN HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A1-LIKE 3 mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723;mRNA 3'-UTR binding#GO:0003730 mRNA splicing, via spliceosome#GO:0000398;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;catalytic step 2 spliceosome#GO:0071013;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HUMAN|HGNC=16903|UniProtKB=Q15025 Q15025 TNIP1 PTHR31882:SF3 TNFAIP3-INTERACTING PROTEIN COILED COIL FAMILY MEMBER TNFAIP3-INTERACTING PROTEIN 1 protein kinase binding#GO:0019901;enzyme binding#GO:0019899;binding#GO:0005488;kinase binding#GO:0019900;mitogen-activated protein kinase binding#GO:0051019;protein binding#GO:0005515 regulation of cell communication#GO:0010646;response to external biotic stimulus#GO:0043207;regulation of cellular process#GO:0050794;negative regulation of canonical NF-kappaB signal transduction#GO:0043124;regulation of macromolecule metabolic process#GO:0060255;negative regulation of MAPK cascade#GO:0043409;cellular response to stimulus#GO:0051716;cellular response to biotic stimulus#GO:0071216;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;response to bacterium#GO:0009617;response to other organism#GO:0051707;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of RNA biosynthetic process#GO:2001141;negative regulation of response to stimulus#GO:0048585;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of canonical NF-kappaB signal transduction#GO:0043122;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;response to external stimulus#GO:0009605;cellular response to molecule of bacterial origin#GO:0071219;regulation of biosynthetic process#GO:0009889;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;response to molecule of bacterial origin#GO:0002237;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;regulation of signaling#GO:0023051;response to oxygen-containing compound#GO:1901700;regulation of intracellular signal transduction#GO:1902531;cellular response to chemical stimulus#GO:0070887;negative regulation of signaling#GO:0023057;negative regulation of signal transduction#GO:0009968;response to lipid#GO:0033993;cellular response to lipid#GO:0071396;negative regulation of ERK1 and ERK2 cascade#GO:0070373;regulation of ERK1 and ERK2 cascade#GO:0070372;response to chemical#GO:0042221;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;cellular response to lipopolysaccharide#GO:0071222;response to biotic stimulus#GO:0009607;response to lipopolysaccharide#GO:0032496;regulation of MAPK cascade#GO:0043408 HUMAN|HGNC=25879|UniProtKB=Q8WXB4 Q8WXB4 ZNF606 PTHR24376:SF255 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 606 regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 gene-specific transcriptional regulator#PC00264;zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=8729|UniProtKB=P12004 P12004 PCNA PTHR11352:SF5 PROLIFERATING CELL NUCLEAR ANTIGEN DNA SLIDING CLAMP PCNA enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 DNA damage response#GO:0006974;DNA damage tolerance#GO:0006301;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;DNA biosynthetic process#GO:0071897;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;response to stress#GO:0006950;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;translesion synthesis#GO:0019985;nucleic acid biosynthetic process#GO:0141187;cellular response to stress#GO:0033554;DNA synthesis involved in DNA replication#GO:0090592;DNA-templated DNA replication#GO:0006261;DNA replication#GO:0006260;cellular response to stimulus#GO:0051716;mismatch repair#GO:0006298;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;DNA strand elongation involved in DNA replication#GO:0006271;response to stimulus#GO:0050896 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 DNA polymerase processivity factor#PC00015 DNA replication#P00017>PCNA#P00534 HUMAN|HGNC=27571|UniProtKB=A6NIN4 A6NIN4 RNF227 PTHR22791:SF14 RING-TYPE DOMAIN-CONTAINING PROTEIN RING FINGER PROTEIN 227 aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746 post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;protein modification process#GO:0036211;primary metabolic process#GO:0044238;cellular process#GO:0009987;protein modification by small protein conjugation#GO:0032446;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=3115|UniProtKB=O00716 O00716 E2F3 PTHR12081:SF44 TRANSCRIPTION FACTOR E2F TRANSCRIPTION FACTOR E2F3 transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357 organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;winged helix/forkhead transcription factor#PC00246;helix-turn-helix transcription factor#PC00116 p53 pathway feedback loops 2#P04398>E2F-1#P04652;p53 pathway#P00059>E2F-1#P04627;Cell cycle#P00013>E2F#P00488 HUMAN|HGNC=28612|UniProtKB=P0CG35 P0CG35 TMSB15B PTHR12021:SF11 THYMOSIN BETA THYMOSIN BETA-15A-RELATED protein binding#GO:0005515;binding#GO:0005488;molecular sequestering activity#GO:0140313;actin monomer binding#GO:0003785;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;protein sequestering activity#GO:0140311 regulation of cell motility#GO:2000145;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;regulation of biological process#GO:0050789;regulation of cell migration#GO:0030334 actin cytoskeleton#GO:0015629;intracellular membraneless organelle#GO:0043232;supramolecular complex#GO:0099080;organelle#GO:0043226;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;actin filament#GO:0005884;cytoskeleton#GO:0005856;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=16277|UniProtKB=Q9C030 Q9C030 TRIM6 PTHR24103:SF51 E3 UBIQUITIN-PROTEIN LIGASE TRIM TRIPARTITE MOTIF-CONTAINING PROTEIN 6 ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;protein binding#GO:0005515;ubiquitin-like protein transferase activity#GO:0019787;protein kinase binding#GO:0019901;ubiquitin protein ligase activity#GO:0061630;enzyme binding#GO:0019899;acyltransferase activity#GO:0016746;kinase binding#GO:0019900;binding#GO:0005488;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740 regulation of biosynthetic process#GO:0009889;innate immune response#GO:0045087;response to external stimulus#GO:0009605;regulation of gene expression#GO:0010468;defense response#GO:0006952;defense response to other organism#GO:0098542;biological regulation#GO:0065007;response to other organism#GO:0051707;response to biotic stimulus#GO:0009607;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;response to stress#GO:0006950;defense response to symbiont#GO:0140546;immune response#GO:0006955;immune system process#GO:0002376;regulation of macromolecule metabolic process#GO:0060255;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=23207|UniProtKB=Q5UIP0 Q5UIP0 RIF1 PTHR22928:SF4 TELOMERE-ASSOCIATED PROTEIN RIF1 TELOMERE-ASSOCIATED PROTEIN RIF1 cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;telomere organization#GO:0032200;telomere maintenance#GO:0000723;chromosome organization#GO:0051276;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170 intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687;chromosome, telomeric repeat region#GO:0140445;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;chromosome, telomeric region#GO:0000781;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;chromosome#GO:0005694 DNA metabolism protein#PC00009 HUMAN|HGNC=9629|UniProtKB=P20962 P20962 PTMS PTHR22745:SF3 PROTHYMOSIN ALPHA PARATHYMOSIN binding#GO:0005488;histone binding#GO:0042393;protein binding#GO:0005515 positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;positive regulation of DNA-templated transcription#GO:0045893;negative regulation of apoptotic process#GO:0043066;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of programmed cell death#GO:0043069;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of apoptotic process#GO:0042981;negative regulation of cellular process#GO:0048523;positive regulation of transcription by RNA polymerase II#GO:0045944 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=11177|UniProtKB=P35610 P35610 SOAT1 PTHR10408:SF6 STEROL O-ACYLTRANSFERASE STEROL O-ACYLTRANSFERASE 1 binding#GO:0005488;small molecule binding#GO:0036094;anion binding#GO:0043168;nucleoside phosphate binding#GO:1901265;acyltransferase activity#GO:0016746;sterol binding#GO:0032934;ion binding#GO:0043167;cholesterol binding#GO:0015485;lipid binding#GO:0008289;catalytic activity#GO:0003824;transferase activity#GO:0016740;alcohol binding#GO:0043178;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;steroid binding#GO:0005496;heterocyclic compound binding#GO:1901363 cholesterol efflux#GO:0033344;cellular process#GO:0009987;cholesterol transport#GO:0030301;macromolecule localization#GO:0033036;steroid metabolic process#GO:0008202;lipid transport#GO:0006869;lipid metabolic process#GO:0006629;transport#GO:0006810;cholesterol metabolic process#GO:0008203;alcohol metabolic process#GO:0006066;metabolic process#GO:0008152;sterol transport#GO:0015918;establishment of localization#GO:0051234;sterol metabolic process#GO:0016125;primary metabolic process#GO:0044238;secondary alcohol metabolic process#GO:1902652;small molecule metabolic process#GO:0044281;lipid localization#GO:0010876;organic hydroxy compound transport#GO:0015850;localization#GO:0051179 endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226 transferase#PC00220;acyltransferase#PC00042 Androgen/estrogene/progesterone biosynthesis#P02727>Cholesterol acyltransferase#P02829 HUMAN|HGNC=3521|UniProtKB=Q99504 Q99504 EYA3 PTHR10190:SF5 EYES ABSENT PROTEIN PHOSPHATASE EYA3 catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725;phosphoprotein phosphatase activity#GO:0004721 positive regulation of metabolic process#GO:0009893;regulation of cellular response to stress#GO:0080135;positive regulation of DNA metabolic process#GO:0051054;regulation of DNA metabolic process#GO:0051052;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of response to stress#GO:0080134;regulation of response to stimulus#GO:0048583;regulation of DNA repair#GO:0006282;developmental process#GO:0032502;cellular developmental process#GO:0048869;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of response to stimulus#GO:0048584;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA repair#GO:0045739;biological regulation#GO:0065007 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 histone modifying enzyme#PC00261 HUMAN|HGNC=3570|UniProtKB=O95573 O95573 ACSL3 PTHR43272:SF13 LONG-CHAIN-FATTY-ACID--COA LIGASE FATTY ACID COA LIGASE ACSL3 catalytic activity#GO:0003824;ligase activity, forming carbon-sulfur bonds#GO:0016877;ligase activity#GO:0016874;ATP-dependent activity#GO:0140657 nucleobase-containing compound metabolic process#GO:0006139;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;long-chain fatty acid metabolic process#GO:0001676;sulfur compound metabolic process#GO:0006790;nucleobase-containing small molecule metabolic process#GO:0055086;acyl-CoA metabolic process#GO:0006637;neurogenesis#GO:0022008;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;neuron differentiation#GO:0030182;developmental process#GO:0032502;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;nucleoside phosphate metabolic process#GO:0006753;cell differentiation#GO:0030154;small molecule metabolic process#GO:0044281;purine-containing compound metabolic process#GO:0072521;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;carboxylic acid metabolic process#GO:0019752;system development#GO:0048731;anatomical structure development#GO:0048856;generation of neurons#GO:0048699;oxoacid metabolic process#GO:0043436;animal gross anatomical part developmental process#GO:0160108 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;lipid droplet#GO:0005811;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;cell periphery#GO:0071944;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 ligase#PC00142 HUMAN|HGNC=11126|UniProtKB=P53814 P53814 SMTN PTHR23167:SF52 CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED SMOOTHELIN organelle organization#GO:0006996;cellular component organization#GO:0016043;actin filament-based process#GO:0030029;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;actin cytoskeleton organization#GO:0030036;cytoskeleton organization#GO:0007010 scaffold/adaptor protein#PC00226 HUMAN|HGNC=18827|UniProtKB=Q86X67 Q86X67 NUDT13 PTHR11383:SF3 NUCLEOSIDE DIPHOSPHATE-LINKED MOIETY X MOTIF 13 NAD(P)H PYROPHOSPHATASE NUDT13, MITOCHONDRIAL HUMAN|HGNC=21353|UniProtKB=Q9H511 Q9H511 KLHL31 PTHR45632:SF17 LD33804P KELCH-LIKE PROTEIN 31 ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 regulation of biological process#GO:0050789;modification-dependent protein catabolic process#GO:0019941;negative regulation of MAPK cascade#GO:0043409;negative regulation of biological process#GO:0048519;primary metabolic process#GO:0044238;regulation of cell communication#GO:0010646;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;protein catabolic process#GO:0030163;regulation of signaling#GO:0023051;modification-dependent macromolecule catabolic process#GO:0043632;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;protein metabolic process#GO:0019538;cellular process#GO:0009987;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;proteasomal protein catabolic process#GO:0010498;negative regulation of signal transduction#GO:0009968;negative regulation of response to stimulus#GO:0048585;regulation of MAPK cascade#GO:0043408;regulation of response to stimulus#GO:0048583;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;negative regulation of cellular process#GO:0048523;ubiquitin-dependent protein catabolic process#GO:0006511;regulation of JNK cascade#GO:0046328;macromolecule metabolic process#GO:0043170 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cullin-RING ubiquitin ligase complex#GO:0031461;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227;ubiquitin ligase complex#GO:0000151;Cul3-RING ubiquitin ligase complex#GO:0031463;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle#GO:0043229 scaffold/adaptor protein#PC00226 HUMAN|HGNC=12568|UniProtKB=Q8IZJ1 Q8IZJ1 UNC5B PTHR12582:SF6 NETRIN RECEPTOR UNC5 NETRIN RECEPTOR UNC5B transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;neuron differentiation#GO:0030182;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;neurogenesis#GO:0022008;neuron projection guidance#GO:0097485;cell projection morphogenesis#GO:0048858;axon guidance#GO:0007411;axon development#GO:0061564;neuron projection development#GO:0031175;cellular process#GO:0009987;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cell morphogenesis involved in neuron differentiation#GO:0048667;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;anatomical structure development#GO:0048856;neuron development#GO:0048666;axonogenesis#GO:0007409;system development#GO:0048731;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell development#GO:0048468 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 Axon guidance mediated by netrin#P00009>UNC-5#P00356 HUMAN|HGNC=37238|UniProtKB=Q6ZR85 Q6ZR85 C17orf107 PTHR38506:SF1 RIKEN CDNA 4930544D05 GENE RIKEN CDNA 4930544D05 GENE HUMAN|HGNC=30130|UniProtKB=Q6TCH7 Q6TCH7 PAQR3 PTHR20855:SF15 ADIPOR/PROGESTIN RECEPTOR-RELATED PROGESTIN AND ADIPOQ RECEPTOR FAMILY MEMBER 3 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 protein localization to organelle#GO:0033365;localization#GO:0051179;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;protein localization to Golgi apparatus#GO:0034067 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=2279|UniProtKB=Q02221 Q02221 COX6A2 PTHR11504:SF1 CYTOCHROME C OXIDASE POLYPEPTIDE VIA CYTOCHROME C OXIDASE SUBUNIT 6A2, MITOCHONDRIAL enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 mitochondrial ATP synthesis coupled electron transport#GO:0042775;cellular process#GO:0009987;respiratory electron transport chain#GO:0022904;electron transport chain#GO:0022900;aerobic respiration#GO:0009060;oxidative phosphorylation#GO:0006119;ATP synthesis coupled electron transport#GO:0042773;cellular respiration#GO:0045333;energy derivation by oxidation of organic compounds#GO:0015980;generation of precursor metabolites and energy#GO:0006091;metabolic process#GO:0008152;aerobic electron transport chain#GO:0019646;mitochondrial electron transport, cytochrome c to oxygen#GO:0006123 catalytic complex#GO:1902494;transporter complex#GO:1990351;respiratory chain complex IV#GO:0045277;transmembrane transporter complex#GO:1902495;oxidoreductase complex#GO:1990204;membrane#GO:0016020;membrane protein complex#GO:0098796;cytochrome complex#GO:0070069;respiratory chain complex#GO:0098803;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 oxidase#PC00175 HUMAN|HGNC=381|UniProtKB=P15121 P15121 AKR1B1 PTHR11732:SF294 ALDO/KETO REDUCTASE ALDO-KETO REDUCTASE FAMILY 1 MEMBER B1 oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;alcohol dehydrogenase (NADP+) activity#GO:0008106;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 reductase#PC00198;oxidoreductase#PC00176 HUMAN|HGNC=2707|UniProtKB=P12821 P12821 ACE PTHR10514:SF25 ANGIOTENSIN-CONVERTING ENZYME ANGIOTENSIN-CONVERTING ENZYME peptidase activity#GO:0008233;hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;catalytic activity, acting on a protein#GO:0140096;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 proteolysis#GO:0006508;circulatory system process#GO:0003013;regulation of biological quality#GO:0065008;signaling receptor ligand precursor processing#GO:0140448;protein metabolic process#GO:0019538;regulation of hormone levels#GO:0010817;primary metabolic process#GO:0044238;positive regulation of blood pressure#GO:0045777;metabolic process#GO:0008152;system process#GO:0003008;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059;peptide hormone processing#GO:0016486;regulation of blood pressure#GO:0008217;regulation of systemic arterial blood pressure#GO:0003073;biosynthetic process#GO:0009058;biological regulation#GO:0065007;blood circulation#GO:0008015;hormone metabolic process#GO:0042445;multicellular organismal process#GO:0032501;protein maturation#GO:0051604;gene expression#GO:0010467 membrane#GO:0016020;extracellular region#GO:0005576;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 metalloprotease#PC00153;protein modifying enzyme#PC00260;protease#PC00190 HUMAN|HGNC=10988|UniProtKB=Q9H1K4 Q9H1K4 SLC25A18 PTHR45678:SF11 MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED MITOCHONDRIAL GLUTAMATE CARRIER 2 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;organelle envelope#GO:0031967;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 secondary carrier transporter#PC00258;transporter#PC00227 HUMAN|HGNC=29371|UniProtKB=Q6GPH6 Q6GPH6 ITPRIPL1 PTHR10656:SF40 CELL FATE DETERMINING PROTEIN MAB21-RELATED INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR-INTERACTING PROTEIN-LIKE 1 catalytic activity#GO:0003824;transferase activity#GO:0016740;nucleotidyltransferase activity#GO:0016779;transferase activity, transferring phosphorus-containing groups#GO:0016772 membrane#GO:0016020;cellular anatomical structure#GO:0110165 transferase#PC00220;nucleotidyltransferase#PC00174 HUMAN|HGNC=24200|UniProtKB=Q6SJ93 Q6SJ93 FAM111B PTHR14389:SF4 SI:CH1073-475A24.1 SERINE PROTEASE FAM111B catalytic activity#GO:0003824;serine-type peptidase activity#GO:0008236;serine hydrolase activity#GO:0017171;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096 macromolecule metabolic process#GO:0043170;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA damage response#GO:0006974;replication fork processing#GO:0031297;nucleobase-containing compound metabolic process#GO:0006139;response to stress#GO:0006950;cellular process#GO:0009987;DNA-templated DNA replication#GO:0006261;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;DNA replication#GO:0006260;cellular response to stimulus#GO:0051716 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;nucleus#GO:0005634;chromatin#GO:0000785;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=7515|UniProtKB=P98088 P98088 MUC5AC PTHR11339:SF401 EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED MUCIN-5AC structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical structure#GO:0110165 extracellular matrix protein#PC00102 HUMAN|HGNC=44409|UniProtKB=H3BPF8 H3BPF8 GOLGA8S PTHR10881:SF7 GOLGIN SUBFAMILY A MEMBER-RELATED GOLGIN SUBFAMILY A CONSERVED DOMAIN-CONTAINING PROTEIN-RELATED endomembrane system organization#GO:0010256;cellular component organization or biogenesis#GO:0071840;Golgi organization#GO:0007030;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;Golgi stack#GO:0005795;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;Golgi cis cisterna#GO:0000137;cytoplasm#GO:0005737;Golgi cisterna#GO:0031985;endomembrane system#GO:0012505;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;cis-Golgi network#GO:0005801;organelle membrane#GO:0031090;Golgi apparatus#GO:0005794 membrane traffic protein#PC00150 HUMAN|HGNC=30681|UniProtKB=Q8N5C8 Q8N5C8 TAB3 PTHR46253:SF3 TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN TAB TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 3 positive regulation of signaling#GO:0023056;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of cell communication#GO:0010646;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789;positive regulation of canonical NF-kappaB signal transduction#GO:0043123;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;positive regulation of response to stimulus#GO:0048584;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of canonical NF-kappaB signal transduction#GO:0043122 HUMAN|HGNC=16447|UniProtKB=Q96SE7 Q96SE7 ZNF347 PTHR24377:SF625 IP01015P-RELATED ZINC FINGER PROTEIN 347-RELATED DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=16131|UniProtKB=Q8IUB5 Q8IUB5 WFDC13 PTHR19441:SF22 WAP four-disulfide core domain protein WAP FOUR-DISULFIDE CORE DOMAIN PROTEIN 13 endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772;enzyme inhibitor activity#GO:0004857;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;serine-type endopeptidase inhibitor activity#GO:0004867;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;peptidase regulator activity#GO:0061134 antimicrobial humoral response#GO:0019730;humoral immune response#GO:0006959;response to external stimulus#GO:0009605;defense response#GO:0006952;antibacterial humoral response#GO:0019731;innate immune response#GO:0045087;defense response to symbiont#GO:0140546;immune response#GO:0006955;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;response to other organism#GO:0051707;defense response to other organism#GO:0098542;defense response to bacterium#GO:0042742;immune system process#GO:0002376;response to bacterium#GO:0009617;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease inhibitor#PC00191 HUMAN|HGNC=20078|UniProtKB=Q70CQ1 Q70CQ1 USP49 PTHR21646:SF7 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 49 cysteine-type deubiquitinase activity#GO:0004843;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787 biological regulation#GO:0065007;regulation of biological quality#GO:0065008;regulation of protein stability#GO:0031647 cysteine protease#PC00081 HUMAN|HGNC=18278|UniProtKB=Q9NS91 Q9NS91 RAD18 PTHR14134:SF2 E3 UBIQUITIN-PROTEIN LIGASE RAD18 E3 UBIQUITIN-PROTEIN LIGASE RAD18 aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746 macromolecule metabolic process#GO:0043170;DNA damage tolerance#GO:0006301;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;nucleobase-containing compound metabolic process#GO:0006139;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;DNA replication#GO:0006260;cellular process#GO:0009987;response to stress#GO:0006950;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;transferase complex#GO:1990234;catalytic complex#GO:1902494;ubiquitin ligase complex#GO:0000151;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=7609|UniProtKB=Q13459 Q13459 MYO9B PTHR46184:SF2 UNCONVENTIONAL MYOSIN-IXB-LIKE PROTEIN UNCONVENTIONAL MYOSIN-IXB isomerase activity#GO:0016853;ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleotide binding#GO:0000166;macromolecular conformation isomerase activity#GO:0120543;catalytic activity#GO:0003824;microfilament motor activity#GO:0000146;pyrophosphatase activity#GO:0016462;ATP hydrolysis activity#GO:0016887;hydrolase activity#GO:0016787;actin filament binding#GO:0051015;anion binding#GO:0043168;small molecule binding#GO:0036094;polypeptide conformation or assembly isomerase activity#GO:0120544;ion binding#GO:0043167;heterocyclic compound binding#GO:1901363;cytoskeletal motor activity#GO:0003774;purine ribonucleotide binding#GO:0032555;ribonucleotide binding#GO:0032553;cytoskeletal protein binding#GO:0008092;hydrolase activity, acting on acid anhydrides#GO:0016817;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;carbohydrate derivative binding#GO:0097367;protein-containing complex binding#GO:0044877;protein binding#GO:0005515;actin binding#GO:0003779;ATP-dependent activity#GO:0140657;ATP binding#GO:0005524;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;nucleoside phosphate binding#GO:1901265 developmental process#GO:0032502;plasma membrane bounded cell projection morphogenesis#GO:0120039;actin filament-based process#GO:0030029;cell projection morphogenesis#GO:0048858;cellular component organization or biogenesis#GO:0071840;anatomical structure development#GO:0048856;anatomical structure morphogenesis#GO:0009653;cellular process#GO:0009987;actin filament-based movement#GO:0030048;cellular component organization#GO:0016043;plasma membrane bounded cell projection organization#GO:0120036;cell projection organization#GO:0030030;cell morphogenesis#GO:0000902 membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;ruffle#GO:0001726;cytoskeleton#GO:0005856;actin filament#GO:0005884;lamellipodium#GO:0030027;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232;cell leading edge#GO:0031252;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;actin cytoskeleton#GO:0015629 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HUMAN|HGNC=9968|UniProtKB=O60673 O60673 REV3L PTHR45812:SF1 DNA POLYMERASE ZETA CATALYTIC SUBUNIT DNA POLYMERASE ZETA CATALYTIC SUBUNIT transferase activity, transferring phosphorus-containing groups#GO:0016772;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on DNA#GO:0140097;DNA polymerase activity#GO:0034061;DNA-directed DNA polymerase activity#GO:0003887 macromolecule metabolic process#GO:0043170;double-strand break repair#GO:0006302;DNA metabolic process#GO:0006259;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA damage tolerance#GO:0006301;DNA damage response#GO:0006974;DNA recombination#GO:0006310;translesion synthesis#GO:0019985;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;response to stress#GO:0006950;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;DNA biosynthetic process#GO:0071897;DNA synthesis involved in DNA replication#GO:0090592;recombinational repair#GO:0000725;nucleic acid biosynthetic process#GO:0141187;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;double-strand break repair via homologous recombination#GO:0000724;DNA replication#GO:0006260 intracellular organelle#GO:0043229;transferase complex#GO:1990234;catalytic complex#GO:1902494;DNA polymerase complex#GO:0042575;transferase complex, transferring phosphorus-containing groups#GO:0061695;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 DNA-directed DNA polymerase#PC00018;DNA metabolism protein#PC00009 HUMAN|HGNC=16442|UniProtKB=Q15391 Q15391 P2RY14 PTHR24233:SF3 P2Y PURINOCEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR P2Y PURINOCEPTOR 14 molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=26996|UniProtKB=P0C7I6 P0C7I6 CCDC159 PTHR34533:SF1 TRANSMEMBRANE PROTEIN CCDC163 COILED-COIL DOMAIN-CONTAINING PROTEIN 159 HUMAN|HGNC=14351|UniProtKB=Q9UHP7 Q9UHP7 CLEC2D PTHR45710:SF41 C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN 180 C-TYPE LECTIN DOMAIN FAMILY 2 MEMBER D molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018 positive regulation of immune system process#GO:0002684;cellular process#GO:0009987;activation of immune response#GO:0002253;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;multicellular organismal process#GO:0032501;positive regulation of response to stimulus#GO:0048584;antigen receptor-mediated signaling pathway#GO:0050851;lymphocyte activation#GO:0046649;immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007;T cell receptor signaling pathway#GO:0050852;regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166;positive regulation of immune response#GO:0050778;immune response-activating signaling pathway#GO:0002757;T cell activation#GO:0042110;leukocyte activation#GO:0045321;immune response-regulating signaling pathway#GO:0002764;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;immune response-activating cell surface receptor signaling pathway#GO:0002429;signaling#GO:0023052;immune system process#GO:0002376;cell activation#GO:0001775;regulation of immune response#GO:0050776;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell surface#GO:0009986;plasma membrane#GO:0005886;membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944 defense/immunity protein#PC00090 HUMAN|HGNC=3122|UniProtKB=O00292 O00292 LEFTY2 PTHR11848:SF232 TGF-BETA FAMILY LEFT-RIGHT DETERMINATION FACTOR 2 cytokine activity#GO:0005125;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546 cellular response to growth factor stimulus#GO:0071363;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;cell communication#GO:0007154;pattern specification process#GO:0007389;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;response to growth factor#GO:0070848;BMP signaling pathway#GO:0030509;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;anterior/posterior axis specification#GO:0009948;multicellular organism development#GO:0007275;cell surface receptor signaling pathway#GO:0007166;response to BMP#GO:0071772;cellular response to BMP stimulus#GO:0071773;developmental process#GO:0032502;anterior/posterior pattern specification#GO:0009952;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;biological regulation#GO:0065007;regionalization#GO:0003002;multicellular organismal process#GO:0032501;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;cellular process#GO:0009987;signal transduction#GO:0007165 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 growth factor#PC00112 TGF-beta signaling pathway#P00052>TGFbeta#P01286 HUMAN|HGNC=6292|UniProtKB=Q9UGI6 Q9UGI6 KCNN3 PTHR10153:SF40 SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL PROTEIN 3 channel activity#GO:0015267;calcium-activated cation channel activity#GO:0005227;potassium ion transmembrane transporter activity#GO:0015079;ligand-gated monoatomic ion channel activity#GO:0015276;potassium channel activity#GO:0005267;monoatomic cation channel activity#GO:0005261;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;monoatomic ion-gated channel activity#GO:0022839;passive transmembrane transporter activity#GO:0022803;calcium-activated potassium channel activity#GO:0015269;ligand-gated channel activity#GO:0022834;monoatomic cation transmembrane transporter activity#GO:0008324;protein binding#GO:0005515;gated channel activity#GO:0022836;binding#GO:0005488;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;calmodulin binding#GO:0005516 cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;metal ion transport#GO:0030001;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813;transport#GO:0006810;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cell projection#GO:0042995;neuronal cell body#GO:0043025;somatodendritic compartment#GO:0036477;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;neuron projection#GO:0043005;cell body#GO:0044297;cell periphery#GO:0071944 ion channel#PC00133;voltage-gated ion channel#PC00241 HUMAN|HGNC=16192|UniProtKB=Q9BYT1 Q9BYT1 SLC17A9 PTHR11662:SF279 SOLUTE CARRIER FAMILY 17 VOLTAGE-GATED PURINE NUCLEOTIDE UNIPORTER SLC17A9 establishment of localization#GO:0051234;organophosphate ester transport#GO:0015748;nucleobase-containing compound transport#GO:0015931;localization#GO:0051179;carbohydrate derivative transport#GO:1901264;transport#GO:0006810;nitrogen compound transport#GO:0071705 secondary carrier transporter#PC00258 HUMAN|HGNC=8324|UniProtKB=Q8NH48 Q8NH48 OR5B3 PTHR48018:SF102 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5B3 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;nervous system process#GO:0050877;sensory perception#GO:0007600;regulation of cellular process#GO:0050794;sensory perception of smell#GO:0007608;response to stimulus#GO:0050896;signaling#GO:0023052;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=3584|UniProtKB=Q00597 Q00597 FANCC PTHR16798:SF0 FANCONI ANEMIA GROUP C PROTEIN FANCC FANCONI ANEMIA GROUP C PROTEIN DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;cellular response to chemical stress#GO:0062197;response to oxidative stress#GO:0006979;response to stress#GO:0006950;cellular process#GO:0009987;cellular response to oxidative stress#GO:0034599;response to chemical#GO:0042221;nucleotide-excision repair#GO:0006289;nucleobase-containing compound metabolic process#GO:0006139;cellular response to chemical stimulus#GO:0070887;cellular response to stress#GO:0033554;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896 nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;Fanconi anaemia nuclear complex#GO:0043240;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=51333|UniProtKB=P0DMR1 P0DMR1 HNRNPCL4 PTHR13968:SF30 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN C-LIKE 3-RELATED RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031 HUMAN|HGNC=40027|UniProtKB=C9JTQ0 C9JTQ0 ANKRD63 PTHR24166:SF30 ROLLING PEBBLES, ISOFORM B ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 63 scaffold/adaptor protein#PC00226 HUMAN|HGNC=15328|UniProtKB=Q8NGE9 Q8NGE9 OR9Q2 PTHR48018:SF144 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 9Q2 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 signaling#GO:0023052;sensory perception of smell#GO:0007608;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cell communication#GO:0007154;nervous system process#GO:0050877;sensory perception#GO:0007600;G protein-coupled receptor signaling pathway#GO:0007186;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;cellular process#GO:0009987;signal transduction#GO:0007165;system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=17736|UniProtKB=P17081 P17081 RHOQ PTHR24072:SF13 RHO FAMILY GTPASE RHO-RELATED GTP-BINDING PROTEIN RHOQ nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;ion binding#GO:0043167;GTPase activity#GO:0003924;small molecule binding#GO:0036094;anion binding#GO:0043168;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;protein binding#GO:0005515;protein kinase binding#GO:0019901;guanyl nucleotide binding#GO:0019001;enzyme binding#GO:0019899;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;kinase binding#GO:0019900 actin filament-based process#GO:0030029;establishment or maintenance of cell polarity#GO:0007163;supramolecular fiber organization#GO:0097435;cell communication#GO:0007154;localization#GO:0051179;cellular response to stimulus#GO:0051716;establishment of cell polarity#GO:0030010;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;signaling#GO:0023052;endocytosis#GO:0006897;regulation of cellular process#GO:0050794;actin cytoskeleton organization#GO:0030036;response to stimulus#GO:0050896;transport#GO:0006810;actin filament organization#GO:0007015;import into cell#GO:0098657;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;signal transduction#GO:0007165;organelle organization#GO:0006996;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 small GTPase#PC00208;G-protein#PC00020 Huntington disease#P00029>Rac#P00775;EGF receptor signaling pathway#P00018>Rac#P00564 HUMAN|HGNC=4069|UniProtKB=Q9BY60 Q9BY60 GABARAPL3 PTHR10969:SF16 MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED GAMMA-AMINOBUTYRIC ACID RECEPTOR-ASSOCIATED PROTEIN-LIKE 3 ubiquitin protein ligase binding#GO:0031625;phospholipid binding#GO:0005543;GABA receptor binding#GO:0050811;ubiquitin-like protein ligase binding#GO:0044389;protein binding#GO:0005515;lipid binding#GO:0008289;binding#GO:0005488;signaling receptor binding#GO:0005102;enzyme binding#GO:0019899 cellular response to stress#GO:0033554;organelle assembly#GO:0070925;process utilizing autophagic mechanism#GO:0061919;vacuole organization#GO:0007033;cellular component disassembly#GO:0022411;cellular response to stimulus#GO:0051716;cellular component organization#GO:0016043;response to starvation#GO:0042594;protein-containing complex disassembly#GO:0032984;catabolic process#GO:0009056;response to stimulus#GO:0050896;cellular response to nutrient levels#GO:0031669;autophagy of mitochondrion#GO:0000422;autophagosome maturation#GO:0097352;metabolic process#GO:0008152;cellular response to starvation#GO:0009267;protein-containing complex organization#GO:0043933;autophagosome assembly#GO:0000045;mitophagy#GO:0000423;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;autophagosome organization#GO:1905037;autophagy#GO:0006914;response to stress#GO:0006950;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;response to nutrient levels#GO:0031667;macroautophagy#GO:0016236;cellular component assembly#GO:0022607 vacuolar membrane#GO:0005774;bounding membrane of organelle#GO:0098588;autophagosome membrane#GO:0000421;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;autophagosome#GO:0005776;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;vacuole#GO:0005773;membrane#GO:0016020 microtubule or microtubule-binding cytoskeletal protein#PC00157;cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HUMAN|HGNC=24994|UniProtKB=Q9NRY2 Q9NRY2 INIP PTHR31526:SF3 SOSS COMPLEX SUBUNIT C SOSS COMPLEX SUBUNIT C cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stress#GO:0006950;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound metabolic process#GO:0006139;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;macromolecule metabolic process#GO:0043170 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=11398|UniProtKB=P49842 P49842 WHR1 PTHR15243:SF0 SERINE/THREONINE-PROTEIN KINASE 19 WINGED HELIX REPAIR FACTOR 1 DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;binding#GO:0005488;nucleic acid binding#GO:0003676 regulation of DNA repair#GO:0006282;regulation of response to stimulus#GO:0048583;regulation of response to stress#GO:0080134;regulation of cellular response to stress#GO:0080135;regulation of DNA metabolic process#GO:0051052;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=39026|UniProtKB=Q9WJR5 Q9WJR5 ERVK-19 PTHR41694:SF3 ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN ENDOGENOUS RETROVIRUS GROUP K MEMBER 10 POL PROTEIN-RELATED nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 viral or transposable element protein#PC00237 HUMAN|HGNC=13275|UniProtKB=P0DPD6 P0DPD6 ECE2 PTHR11733:SF127 ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED EEF1AKMT4-ECE2 READTHROUGH TRANSCRIPT PROTEIN-RELATED metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 proteolysis#GO:0006508;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;protein processing#GO:0016485;cellular process#GO:0009987;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 protease#PC00190;metalloprotease#PC00153 Endothelin signaling pathway#P00019>ECE1-3#P00585 HUMAN|HGNC=12645|UniProtKB=O75379 O75379 VAMP4 PTHR46897:SF1 VESICLE-ASSOCIATED MEMBRANE PROTEIN 4 VESICLE-ASSOCIATED MEMBRANE PROTEIN 4 transport#GO:0006810;intracellular transport#GO:0046907;regulation of transport#GO:0051049;vesicle-mediated transport to the plasma membrane#GO:0098876;regulation of localization#GO:0032879;endosomal transport#GO:0016197;establishment of localization#GO:0051234;establishment of localization in cell#GO:0051649;regulation of protein localization to membrane#GO:1905475;cellular process#GO:0009987;biological regulation#GO:0065007;vesicle-mediated transport#GO:0016192;localization within membrane#GO:0051668;regulation of protein localization#GO:0032880;regulation of establishment of protein localization#GO:0070201;localization#GO:0051179;cellular localization#GO:0051641;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;endocytic recycling#GO:0032456;regulation of protein transport#GO:0051223;regulation of cellular process#GO:0050794 cell junction#GO:0030054;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;Golgi apparatus#GO:0005794;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;vesicle membrane#GO:0012506;presynapse#GO:0098793;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endosome#GO:0005768;endosome membrane#GO:0010008;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;SNARE complex#GO:0031201;synapse#GO:0045202;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;vesicle#GO:0031982 HUMAN|HGNC=19953|UniProtKB=Q8IWX5 Q8IWX5 SGPP2 PTHR14969:SF14 SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE SPHINGOSINE-1-PHOSPHATE PHOSPHATASE 2 hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788 small molecule metabolic process#GO:0044281;primary metabolic process#GO:0044238;phospholipid dephosphorylation#GO:0046839;phosphate-containing compound metabolic process#GO:0006796;cellular process#GO:0009987;dephosphorylation#GO:0016311;lipid modification#GO:0030258;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;alcohol metabolic process#GO:0006066;lipid metabolic process#GO:0006629 membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090 phosphatase#PC00181;hydrolase#PC00121 HUMAN|HGNC=33803|UniProtKB=Q2NL98 Q2NL98 VMAC PTHR34707:SF1 VIMENTIN-TYPE INTERMEDIATE FILAMENT-ASSOCIATED COILED-COIL PROTEIN VIMENTIN-TYPE INTERMEDIATE FILAMENT-ASSOCIATED COILED-COIL PROTEIN HUMAN|HGNC=15788|UniProtKB=Q96DT0 Q96DT0 LGALS12 PTHR11346:SF111 GALECTIN GALECTIN-12 binding#GO:0005488;oligosaccharide binding#GO:0070492;carbohydrate binding#GO:0030246 programmed cell death#GO:0012501;apoptotic process#GO:0006915;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell death#GO:0008219;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;intrinsic apoptotic signaling pathway#GO:0097193;apoptotic signaling pathway#GO:0097190;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 extracellular matrix protein#PC00102 HUMAN|HGNC=31658|UniProtKB=A0PK05 A0PK05 TMEM72 PTHR28474:SF1 TRANSMEMBRANE PROTEIN 72 TRANSMEMBRANE PROTEIN 72 HUMAN|HGNC=9210|UniProtKB=P28069 P28069 POU1F1 PTHR11636:SF84 POU DOMAIN PITUITARY-SPECIFIC POSITIVE TRANSCRIPTION FACTOR 1 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=21869|UniProtKB=Q53H12 Q53H12 AGK PTHR12358:SF86 SPHINGOSINE KINASE ACYLGLYCEROL KINASE, MITOCHONDRIAL phosphotransferase activity, alcohol group as acceptor#GO:0016773;lipid kinase activity#GO:0001727;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740 biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;small molecule metabolic process#GO:0044281;cellular process#GO:0009987;alcohol biosynthetic process#GO:0046165;primary metabolic process#GO:0044238;sphingoid biosynthetic process#GO:0046520;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;sphingolipid biosynthetic process#GO:0030148;alcohol metabolic process#GO:0006066;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152 metabolite interconversion enzyme#PC00262;kinase#PC00137;transferase#PC00220 HUMAN|HGNC=12712|UniProtKB=Q9H267 Q9H267 VPS33B PTHR11679:SF92 VESICLE PROTEIN SORTING-ASSOCIATED VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 33B establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;macromolecule localization#GO:0033036;vesicle-mediated transport#GO:0016192;transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;protein transport#GO:0015031;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641 lytic vacuole#GO:0000323;vesicle tethering complex#GO:0099023;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;vacuole#GO:0005773;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular vesicle#GO:0097708;vesicle#GO:0031982;lysosome#GO:0005764;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=1361|UniProtKB=Q8N6M6 Q8N6M6 AOPEP PTHR46627:SF1 AMINOPEPTIDASE O AMINOPEPTIDASE O intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226 protease#PC00190 HUMAN|HGNC=1152|UniProtKB=Q8NE79 Q8NE79 POPDC1 PTHR12101:SF17 POPEYE DOMAIN CONTAINING PROTEIN POPEYE DOMAIN-CONTAINING PROTEIN 1 nucleotide binding#GO:0000166;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;ribonucleotide binding#GO:0032553;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;binding#GO:0005488;small molecule binding#GO:0036094;anion binding#GO:0043168;ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265 muscle cell differentiation#GO:0042692;circulatory system development#GO:0072359;cell differentiation#GO:0030154;muscle structure development#GO:0061061;animal gross anatomical part developmental process#GO:0160108;cell adhesion#GO:0007155;anatomical structure development#GO:0048856;system development#GO:0048731;regulation of biological quality#GO:0065008;cell-cell adhesion#GO:0098609;cellular process#GO:0009987;heart development#GO:0007507;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;developmental process#GO:0032502;multicellular organism development#GO:0007275;regulation of membrane potential#GO:0042391;cellular developmental process#GO:0048869;animal organ development#GO:0048513;striated muscle cell differentiation#GO:0051146 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;bicellular tight junction#GO:0005923;cell periphery#GO:0071944;cell-cell junction#GO:0005911;membrane#GO:0016020;anchoring junction#GO:0070161;tight junction#GO:0070160;sarcolemma#GO:0042383;cell junction#GO:0030054;apical junction complex#GO:0043296 HUMAN|HGNC=8504|UniProtKB=Q969R2 Q969R2 OSBP2 PTHR10972:SF194 OXYSTEROL-BINDING PROTEIN-RELATED OXYSTEROL-BINDING PROTEIN 2 sterol binding#GO:0032934;binding#GO:0005488;small molecule binding#GO:0036094;cholesterol binding#GO:0015485;lipid binding#GO:0008289;steroid binding#GO:0005496;alcohol binding#GO:0043178 membrane#GO:0016020;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 transfer/carrier protein#PC00219 HUMAN|HGNC=20217|UniProtKB=Q9NVH0 Q9NVH0 EXD2 PTHR13620:SF133 3-5 EXONUCLEASE EXONUCLEASE 3'-5' DOMAIN-CONTAINING PROTEIN 2 catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;DNA exonuclease activity#GO:0004529;hydrolase activity, acting on ester bonds#GO:0016788;DNA nuclease activity#GO:0004536;catalytic activity, acting on DNA#GO:0140097;RNA nuclease activity#GO:0004540;3'-5' exonuclease activity#GO:0008408;catalytic activity, acting on RNA#GO:0140098;exonuclease activity#GO:0004527;3'-5'-RNA exonuclease activity#GO:0000175;hydrolase activity#GO:0016787;nuclease activity#GO:0004518;DNA exonuclease activity, producing 5'-phosphomonoesters#GO:0016895;3'-5'-DNA exonuclease activity#GO:0008296 response to stress#GO:0006950;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;DNA repair#GO:0006281;nucleobase-containing compound biosynthetic process#GO:0034654;DNA metabolic process#GO:0006259;DNA damage response#GO:0006974;DNA recombination#GO:0006310;macromolecule metabolic process#GO:0043170;double-strand break repair#GO:0006302;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;double-strand break repair via homologous recombination#GO:0000724;response to stimulus#GO:0050896;RNA biosynthetic process#GO:0032774;recombinational repair#GO:0000725;nucleic acid biosynthetic process#GO:0141187;cellular response to stress#GO:0033554;RNA metabolic process#GO:0016070 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;mitochondrion#GO:0005739;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=6528|UniProtKB=P13796 P13796 LCP1 PTHR19961:SF35 FIMBRIN/PLASTIN PLASTIN-2 cytoskeletal protein binding#GO:0008092;molecular adaptor activity#GO:0060090;protein-containing complex binding#GO:0044877;protein binding#GO:0005515;actin filament binding#GO:0051015;actin binding#GO:0003779;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674 cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;actin cytoskeleton organization#GO:0030036;actin filament bundle assembly#GO:0051017;cellular process#GO:0009987;actin filament bundle organization#GO:0061572;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular component organization#GO:0016043;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029 actin cytoskeleton#GO:0015629;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;actin filament bundle#GO:0032432;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membrane#GO:0016020;cell periphery#GO:0071944;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;actin filament#GO:0005884;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228 non-motor actin binding protein#PC00165;actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=1212|UniProtKB=O95466 O95466 FMNL1 PTHR45857:SF2 FORMIN-LIKE PROTEIN FORMIN-LIKE PROTEIN 1 protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;actin binding#GO:0003779;actin filament binding#GO:0051015;cytoskeletal protein binding#GO:0008092 cell motility#GO:0048870;cell migration#GO:0016477;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 HUMAN|HGNC=28638|UniProtKB=Q7L5L3 Q7L5L3 GDPD3 PTHR42758:SF3 PHOSPHATIDYLGLYCEROL PHOSPHOLIPASE C LYSOPHOSPHOLIPASE D GDPD3 lipase activity#GO:0016298;phosphatidylcholine lysophospholipase A1 activity#GO:0004622;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;glycerophospholipase activity#GO:0004620;phospholipase activity#GO:0120569;hydrolase activity, acting on ester bonds#GO:0016788;phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578 metabolic process#GO:0008152;glycerolipid catabolic process#GO:0046503;lipid metabolic process#GO:0006629;glycerophospholipid catabolic process#GO:0046475;organophosphate catabolic process#GO:0046434;organophosphate metabolic process#GO:0019637;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;lipid catabolic process#GO:0016042;cellular process#GO:0009987;glycerolipid metabolic process#GO:0046486;phospholipid catabolic process#GO:0009395;catabolic process#GO:0009056;glycerophospholipid metabolic process#GO:0006650;phospholipid metabolic process#GO:0006644 membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;membrane#GO:0016020 phospholipase#PC00186;lipase#PC00143;hydrolase#PC00121 HUMAN|HGNC=24978|UniProtKB=Q96KN8 Q96KN8 PLAAT5 PTHR13943:SF2 HRAS-LIKE SUPPRESSOR - RELATED PHOSPHOLIPASE A AND ACYLTRANSFERASE 5 glycerophospholipase activity#GO:0004620;catalytic activity#GO:0003824;transferase activity#GO:0016740;hydrolase activity, acting on ester bonds#GO:0016788;phospholipase activity#GO:0120569;A2-type glycerophospholipase activity#GO:0004623;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acyltransferase activity#GO:0016746;lipase activity#GO:0016298;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity#GO:0016787 cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phospholipid metabolic process#GO:0006644;glycerolipid metabolic process#GO:0046486;glycerophospholipid metabolic process#GO:0006650;lipid metabolic process#GO:0006629;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 metabolite interconversion enzyme#PC00262;acyltransferase#PC00042 HUMAN|HGNC=25417|UniProtKB=Q8N4V2 Q8N4V2 SVOP PTHR24064:SF673 SOLUTE CARRIER FAMILY 22 MEMBER SYNAPTIC VESICLE 2-RELATED PROTEIN transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 transport#GO:0006810;cellular process#GO:0009987;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 secondary carrier transporter#PC00258 HUMAN|HGNC=10483|UniProtKB=P21817 P21817 RYR1 PTHR46399:SF10 B30.2/SPRY DOMAIN-CONTAINING PROTEIN RYANODINE RECEPTOR 1 transporter activity#GO:0005215;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;gated channel activity#GO:0022836;calcium ion transmembrane transporter activity#GO:0015085;ligand-gated calcium channel activity#GO:0099604;monoatomic cation transmembrane transporter activity#GO:0008324;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;ligand-gated monoatomic cation channel activity#GO:0099094;monoatomic cation channel activity#GO:0005261;ligand-gated monoatomic ion channel activity#GO:0015276;channel activity#GO:0015267 muscle contraction#GO:0006936;transport#GO:0006810;system process#GO:0003008;calcium ion transport#GO:0006816;establishment of localization#GO:0051234;calcium ion transmembrane import into cytosol#GO:0097553;cellular process#GO:0009987;release of sequestered calcium ion into cytosol#GO:0051209;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;release of sequestered calcium ion into cytosol by sarcoplasmic reticulum#GO:0014808;multicellular organismal process#GO:0032501;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;muscle system process#GO:0003012;calcium ion transmembrane transport#GO:0070588;metal ion transport#GO:0030001;striated muscle contraction#GO:0006941 membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum subcompartment#GO:0098827;sarcoplasm#GO:0016528;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transmembrane transporter complex#GO:1902495;Z disc#GO:0030018;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;monoatomic ion channel complex#GO:0034702;endomembrane system#GO:0012505;I band#GO:0031674;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;membraneless organelle#GO:0043228;sarcolemma#GO:0042383;calcium channel complex#GO:0034704;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;intracellular organelle#GO:0043229;organelle subcompartment#GO:0031984;supramolecular fiber#GO:0099512;myofibril#GO:0030016;contractile muscle fiber#GO:0043292;sarcoplasmic reticulum#GO:0016529;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;sarcoplasmic reticulum membrane#GO:0033017;supramolecular complex#GO:0099080;endoplasmic reticulum#GO:0005783;cation channel complex#GO:0034703;bounding membrane of organelle#GO:0098588;transporter complex#GO:1990351;sarcomere#GO:0030017 Beta1 adrenergic receptor signaling pathway#P04377>ER-type Ca2+ channel#P04434;Beta2 adrenergic receptor signaling pathway#P04378>ER-type Ca2+ channel#P04441;CCKR signaling map#P06959>RYR1/2/3#P07088 HUMAN|HGNC=6974|UniProtKB=O15151 O15151 MDM4 PTHR12183:SF37 MITOCHONDRIAL UBIQUITIN LIGASE ACTIVATOR OF NFKB 1 PROTEIN MDM4 negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;regulation of cellular component organization#GO:0051128;negative regulation of metabolic process#GO:0009892;positive regulation of mitochondrial fission#GO:0090141;positive regulation of cellular component organization#GO:0051130;positive regulation of organelle organization#GO:0010638;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of biological quality#GO:0065008;negative regulation of macromolecule biosynthetic process#GO:0010558;positive regulation of biological process#GO:0048518;regulation of protein stability#GO:0031647;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of anatomical structure morphogenesis#GO:0022603;protein stabilization#GO:0050821;regulation of mitochondrion organization#GO:0010821;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of developmental process#GO:0050793;regulation of mitochondrial fission#GO:0090140;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;negative regulation of cellular process#GO:0048523;positive regulation of developmental process#GO:0051094;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 protein-containing complex#GO:0032991;cytoplasm#GO:0005737;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;transcription regulator complex#GO:0005667;transcription repressor complex#GO:0017053;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 p53 pathway#P00059>Mdm2#P01483;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>Mdm2#G04674;P53 pathway feedback loops 1#P04392>Mdm2#P04536;P53 pathway feedback loops 1#P04392>MDM-2#G04682;p53 pathway feedback loops 2#P04398>MDM-2#G04709;p53 pathway feedback loops 2#P04398>Mdm2#P04663;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>Mdm2#P04496;p53 pathway#P00059>MDM-2#G01563 HUMAN|HGNC=27879|UniProtKB=P0DP72 P0DP72 VSIG10L2 PTHR11640:SF171 NEPHRIN V-SET AND IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN 10-LIKE 2 protein binding#GO:0005515;cell adhesion molecule binding#GO:0050839;binding#GO:0005488 cell adhesion#GO:0007155;cellular process#GO:0009987;cell-cell adhesion#GO:0098609 plasma membrane#GO:0005886;anchoring junction#GO:0070161;cell junction#GO:0030054;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;cell-cell junction#GO:0005911 cell adhesion molecule#PC00069;immunoglobulin superfamily cell adhesion molecule#PC00125 HUMAN|HGNC=1756|UniProtKB=Q12864 Q12864 CDH17 PTHR24027:SF419 CADHERIN-23 CADHERIN-17 binding#GO:0005488;cell adhesion molecule binding#GO:0050839;protein binding#GO:0005515;beta-catenin binding#GO:0008013 cellular process#GO:0009987;cell adhesion#GO:0007155;cell-cell adhesion#GO:0098609;cell migration#GO:0016477;cell motility#GO:0048870 extrinsic component of plasma membrane#GO:0019897;extrinsic component of membrane#GO:0019898;membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cadherin#PC00057;cell adhesion molecule#PC00069 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HUMAN|HGNC=27998|UniProtKB=Q6NXP2 Q6NXP2 GARIN1A PTHR22574:SF10 FAMILY NOT NAMED GOLGI-ASSOCIATED RAB2 INTERACTOR PROTEIN 1A HUMAN|HGNC=26516|UniProtKB=Q6P9G0 Q6P9G0 CYB5D1 PTHR21281:SF1 CYTOCHROME B5 DOMAIN-CONTAINING PROTEIN 1 CYTOCHROME B5 DOMAIN-CONTAINING PROTEIN 1 microtubule-based process#GO:0007017;microtubule-based movement#GO:0007018;cilium movement#GO:0003341;cellular process#GO:0009987 HUMAN|HGNC=17151|UniProtKB=Q9Y5N6 Q9Y5N6 ORC6 PTHR13394:SF0 ORIGIN RECOGNITION COMPLEX SUBUNIT 6 ORIGIN RECOGNITION COMPLEX SUBUNIT 6 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;DNA replication#GO:0006260;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;DNA replication initiation#GO:0006270;DNA-templated DNA replication#GO:0006261;macromolecule metabolic process#GO:0043170 nuclear origin of replication recognition complex#GO:0005664;membraneless organelle#GO:0043228;origin recognition complex#GO:0000808;nuclear protein-containing complex#GO:0140513;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;chromosome#GO:0005694;organelle lumen#GO:0043233;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 DNA metabolism protein#PC00009;replication origin binding protein#PC00199 HUMAN|HGNC=388|UniProtKB=P51857 P51857 AKR1D1 PTHR11732:SF211 ALDO/KETO REDUCTASE ALDO-KETO REDUCTASE FAMILY 1 MEMBER D1 oxidoreductase activity#GO:0016491;alcohol dehydrogenase (NADP+) activity#GO:0008106;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen#GO:0016709;catalytic activity#GO:0003824;monooxygenase activity#GO:0004497;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455 hormone metabolic process#GO:0042445;steroid metabolic process#GO:0008202;biological regulation#GO:0065007;primary metabolic process#GO:0044238;regulation of hormone levels#GO:0010817;cellular process#GO:0009987;regulation of biological quality#GO:0065008;metabolic process#GO:0008152;lipid metabolic process#GO:0006629 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 reductase#PC00198;oxidoreductase#PC00176 HUMAN|HGNC=17063|UniProtKB=Q15042 Q15042 RAB3GAP1 PTHR21422:SF18 RAB3 GTPASE-ACTIVATING PROTEIN CATALYTIC SUBUNIT RAB3 GTPASE-ACTIVATING PROTEIN CATALYTIC SUBUNIT enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772 system development#GO:0048731;anatomical structure development#GO:0048856;regulation of cellular process#GO:0050794;developmental process#GO:0032502;regulation of catabolic process#GO:0009894;positive regulation of catabolic process#GO:0009896;regulation of organelle assembly#GO:1902115;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;brain development#GO:0007420;positive regulation of cellular component organization#GO:0051130;animal gross anatomical part developmental process#GO:0160108;regulation of autophagosome assembly#GO:2000785;positive regulation of organelle organization#GO:0010638;positive regulation of metabolic process#GO:0009893;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of autophagy#GO:0010506;regulation of cellular component biogenesis#GO:0044087;positive regulation of macroautophagy#GO:0016239;regulation of cellular component organization#GO:0051128;central nervous system development#GO:0007417;regulation of macroautophagy#GO:0016241;animal organ development#GO:0048513;multicellular organism development#GO:0007275;positive regulation of biological process#GO:0048518;positive regulation of autophagy#GO:0010508;nervous system development#GO:0007399;head development#GO:0060322;positive regulation of cellular component biogenesis#GO:0044089 GTPase-activating protein#PC00257;G-protein modulator#PC00022 HUMAN|HGNC=11367|UniProtKB=P51692 P51692 STAT5B PTHR11801:SF39 SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 response to hormone#GO:0009725;response to stress#GO:0006950;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;response to cytokine#GO:0034097;response to chemical#GO:0042221;cell surface receptor signaling pathway via STAT#GO:0097696;cell surface receptor signaling pathway#GO:0007166;response to endogenous stimulus#GO:0009719;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;cellular response to hormone stimulus#GO:0032870;cellular response to endogenous stimulus#GO:0071495;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;signaling#GO:0023052;cellular response to chemical stimulus#GO:0070887;response to oxygen-containing compound#GO:1901700;response to peptide#GO:1901652;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular response to nitrogen compound#GO:1901699;regulation of nucleobase-containing compound metabolic process#GO:0019219;response to peptide hormone#GO:0043434;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;cell surface receptor signaling pathway via JAK-STAT#GO:0007259;regulation of biosynthetic process#GO:0009889;defense response#GO:0006952;regulation of gene expression#GO:0010468;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;cellular response to peptide hormone stimulus#GO:0071375;cytokine-mediated signaling pathway#GO:0019221;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of DNA-templated transcription#GO:0006355;regulation of cell population proliferation#GO:0042127;cell communication#GO:0007154;regulation of RNA metabolic process#GO:0051252;response to nitrogen compound#GO:1901698 intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 Rel homology transcription factor#PC00252;immunoglobulin fold transcription factor#PC00251 Interleukin signaling pathway#P00036>STAT#P00996;EGF receptor signaling pathway#P00018>STAT#P00561;PDGF signaling pathway#P00047>STAT#P01173;JAK/STAT signaling pathway#P00038>STAT#P01027 HUMAN|HGNC=9600|UniProtKB=P43088 P43088 PTGFR PTHR11866:SF4 G-PROTEIN COUPLED RECEPTOR FAMILY 1 MEMBER PROSTAGLANDIN F2-ALPHA RECEPTOR molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154;regulation of biological quality#GO:0065008;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;positive regulation of cytosolic calcium ion concentration#GO:0007204;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 Gonadotropin-releasing hormone receptor pathway#P06664>PG Rcs#P06836 HUMAN|HGNC=4613|UniProtKB=O15499 O15499 GSC2 PTHR46643:SF1 HOMEOBOX PROTEIN GOOSECOID-RELATED HOMEOBOX PROTEIN GOOSECOID-2 transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 HUMAN|HGNC=21957|UniProtKB=Q96MP8 Q96MP8 KCTD7 PTHR14499:SF122 POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD7 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 regulation of membrane potential#GO:0042391;biological regulation#GO:0065007;regulation of biological quality#GO:0065008 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=28563|UniProtKB=Q53QW1 Q53QW1 TEX44 PTHR37365:SF1 TESTIS-EXPRESSED PROTEIN 44 TESTIS-EXPRESSED PROTEIN 44 HUMAN|HGNC=9066|UniProtKB=P16885 P16885 PLCG2 PTHR10336:SF25 PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN 1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2 glycerophospholipase activity#GO:0004620;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phospholipase activity#GO:0120569;phosphoric ester hydrolase activity#GO:0042578;phosphoric diester hydrolase activity#GO:0008081;lipase activity#GO:0016298;hydrolase activity#GO:0016787 positive regulation of locomotion#GO:0040017;establishment of localization#GO:0051234;lipid metabolic process#GO:0006629;phosphatidylinositol metabolic process#GO:0046488;transport#GO:0006810;regulation of cell migration#GO:0030334;regulation of locomotion#GO:0040012;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;positive regulation of cell migration#GO:0030335;positive regulation of cellular process#GO:0048522;organophosphate metabolic process#GO:0019637;intracellular signal transduction#GO:0035556;regulation of cell motility#GO:2000145;monoatomic cation transport#GO:0006812;cell communication#GO:0007154;localization#GO:0051179;phospholipid metabolic process#GO:0006644;metal ion transport#GO:0030001;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;calcium ion transport#GO:0006816;calcium ion transmembrane import into cytosol#GO:0097553;metabolic process#GO:0008152;regulation of multicellular organismal process#GO:0051239;monoatomic cation transmembrane transport#GO:0098655;glycerophospholipid metabolic process#GO:0006650;cellular process#GO:0009987;release of sequestered calcium ion into cytosol#GO:0051209;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;signaling#GO:0023052;response to stimulus#GO:0050896;glycerolipid metabolic process#GO:0046486;regulation of biological process#GO:0050789;phosphorus metabolic process#GO:0006793;positive regulation of cell motility#GO:2000147;calcium ion transmembrane transport#GO:0070588 leading edge membrane#GO:0031256;ruffle membrane#GO:0032587;ruffle#GO:0001726;cell projection membrane#GO:0031253;cell periphery#GO:0071944;membrane#GO:0016020;cell leading edge#GO:0031252;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590 hydrolase#PC00121;metabolite interconversion enzyme#PC00262;phospholipase#PC00186;lipase#PC00143 VEGF signaling pathway#P00056>PLC-gamma#P01414;FGF signaling pathway#P00021>PLCgamma#P00638;Thyrotropin-releasing hormone receptor signaling pathway#P04394>PLC#P04581;B cell activation#P00010>PLC gamma2#P00388;Angiogenesis#P00005>PLC-gamma#P00256;Oxytocin receptor mediated signaling pathway#P04391>PLC beta#P04530;Axon guidance mediated by netrin#P00009>Phospholipase C#P00362;EGF receptor signaling pathway#P00018>PLCgamma#P00556;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PLCbetagamma#P00874;Histamine H1 receptor mediated signaling pathway#P04385>PLC#P04484;PDGF signaling pathway#P00047>PLCgamma#P01171;5HT2 type receptor mediated signaling pathway#P04374>PLC#P04412 HUMAN|HGNC=18027|UniProtKB=Q3B726 Q3B726 POLR1F PTHR12709:SF5 DNA-DIRECTED RNA POLYMERASE II, III DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43 nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;transcription by RNA polymerase I#GO:0006360;DNA-templated transcription elongation#GO:0006354;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139 intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;transferase complex#GO:1990234;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;RNA polymerase I complex#GO:0005736;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle lumen#GO:0043233 DNA-directed RNA polymerase#PC00019;RNA metabolism protein#PC00031 HUMAN|HGNC=10296|UniProtKB=Q9UNE2 Q9UNE2 RPH3AL PTHR45729:SF4 RABPHILIN, ISOFORM A RAB EFFECTOR NOC2 regulation of secretion#GO:0051046;regulation of exocytosis#GO:0017157;regulation of secretion by cell#GO:1903530;regulation of localization#GO:0032879;regulation of transport#GO:0051049;positive regulation of secretion#GO:0051047;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;positive regulation of cellular process#GO:0048522;positive regulation of secretion by cell#GO:1903532;regulation of vesicle-mediated transport#GO:0060627;positive regulation of transport#GO:0051050;positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789 HUMAN|HGNC=31407|UniProtKB=A6NEK1 A6NEK1 ARRDC5 PTHR11188:SF172 ARRESTIN DOMAIN CONTAINING PROTEIN ARRESTIN DOMAIN-CONTAINING PROTEIN 5 plasma membrane#GO:0005886;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;cell periphery#GO:0071944;intracellular vesicle#GO:0097708;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endosome#GO:0005768 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=30033|UniProtKB=Q9NRX4 Q9NRX4 PHPT1 PTHR12258:SF10 JANUS-A/JANUS-B 14 KDA PHOSPHOHISTIDINE PHOSPHATASE catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;phosphoprotein phosphatase activity#GO:0004721 regulation of cell motility#GO:2000145;positive regulation of locomotion#GO:0040017;positive regulation of cell motility#GO:2000147;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of locomotion#GO:0040012;biological regulation#GO:0065007 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=16959|UniProtKB=O15498 O15498 YKT6 PTHR45806:SF1 SYNAPTOBREVIN HOMOLOG YKT6 SYNAPTOBREVIN HOMOLOG YKT6 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;SNAP receptor activity#GO:0005484 vesicle-mediated transport#GO:0016192;organelle fusion#GO:0048284;organelle membrane fusion#GO:0090174;vacuole fusion, non-autophagic#GO:0042144;macroautophagy#GO:0016236;membrane organization#GO:0061024;membrane fusion#GO:0061025;organelle organization#GO:0006996;cellular process#GO:0009987;autophagy#GO:0006914;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;vesicle organization#GO:0016050;metabolic process#GO:0008152;transport#GO:0006810;Golgi vesicle transport#GO:0048193;catabolic process#GO:0009056;vesicle fusion#GO:0006906;cellular component organization#GO:0016043;intra-Golgi vesicle-mediated transport#GO:0006891;localization#GO:0051179;process utilizing autophagic mechanism#GO:0061919;vacuole organization#GO:0007033;vacuole fusion#GO:0097576 protein-containing complex#GO:0032991;endomembrane system#GO:0012505;vacuole#GO:0005773;cytoplasm#GO:0005737;membrane#GO:0016020;vacuolar membrane#GO:0005774;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;Golgi apparatus#GO:0005794;organelle#GO:0043226;cellular anatomical structure#GO:0110165;SNARE complex#GO:0031201;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;vesicle#GO:0031982;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;autophagosome membrane#GO:0000421;autophagosome#GO:0005776;intracellular organelle#GO:0043229 HUMAN|HGNC=17317|UniProtKB=Q9Y584 Q9Y584 TIMM22 PTHR14110:SF0 MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22 MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22 protein carrier activity#GO:0140597;membrane insertase activity#GO:0032977;molecular carrier activity#GO:0140104 transport#GO:0006810;intracellular transport#GO:0046907;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;inner mitochondrial membrane organization#GO:0007007;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;mitochondrial membrane organization#GO:0007006;organelle organization#GO:0006996;protein insertion into mitochondrial inner membrane#GO:0045039;membrane organization#GO:0061024;mitochondrial protein import pathway#GO:7770058;mitochondrion organization#GO:0007005;cellular localization#GO:0051641;localization#GO:0051179;cellular component organization#GO:0016043;mitochondrial transport#GO:0006839 inner mitochondrial membrane protein complex#GO:0098800;organelle membrane#GO:0031090;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;intracellular organelle#GO:0043229;TIM22 mitochondrial import inner membrane insertion complex#GO:0042721;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;organelle envelope#GO:0031967;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 transporter#PC00227 HUMAN|HGNC=14693|UniProtKB=Q8NGX5 Q8NGX5 OR10K1 PTHR26451:SF977 G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN OLFACTORY RECEPTOR 10K1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;binding#GO:0005488 response to stimulus#GO:0050896;response to chemical#GO:0042221;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;detection of chemical stimulus#GO:0009593;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;system process#GO:0003008;sensory perception#GO:0007600;nervous system process#GO:0050877;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907 cellular anatomical structure#GO:0110165;membrane#GO:0016020 G-protein coupled receptor#PC00021 HUMAN|HGNC=5322|UniProtKB=O43820 O43820 HYAL3 PTHR11769:SF19 HYALURONIDASE HYALURONIDASE-3 aminoglycan metabolic process#GO:0006022;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;glycosaminoglycan catabolic process#GO:0006027;macromolecule metabolic process#GO:0043170;aminoglycan catabolic process#GO:0006026;glycosaminoglycan metabolic process#GO:0030203;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;catabolic process#GO:0009056;carbohydrate derivative catabolic process#GO:1901136 secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;acrosomal vesicle#GO:0001669;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;vesicle#GO:0031982;intracellular vesicle#GO:0097708;secretory vesicle#GO:0099503 glycosidase#PC00110 HUMAN|HGNC=9897|UniProtKB=P57052 P57052 RBM11 PTHR13798:SF5 RNA BINDING MOTIF RBM PROTEIN -RELATED SPLICING REGULATOR RBM11 nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723;single-stranded RNA binding#GO:0003727 regulation of RNA metabolic process#GO:0051252;regulation of alternative mRNA splicing, via spliceosome#GO:0000381;regulation of biological process#GO:0050789;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of mRNA metabolic process#GO:1903311;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of mRNA processing#GO:0050684;regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 RNA metabolism protein#PC00031 HUMAN|HGNC=13236|UniProtKB=O94763 O94763 URI1 PTHR15111:SF2 RNA POLYMERASE II SUBUNIT 5-MEDIATING PROTEIN NNX3 UNCONVENTIONAL PREFOLDIN RPB5 INTERACTOR 1 molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;transcription regulator activity#GO:0140110;chromatin binding#GO:0003682;binding#GO:0005488;phosphatase inhibitor activity#GO:0019212;molecular function regulator activity#GO:0098772;phosphatase regulator activity#GO:0019208;enzyme inhibitor activity#GO:0004857;transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714 negative regulation of intrinsic apoptotic signaling pathway#GO:2001243;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of apoptotic process#GO:0042981;negative regulation of signal transduction#GO:0009968;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of programmed cell death#GO:0043069;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of cell communication#GO:0010648;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of apoptotic process#GO:0043066;negative regulation of response to stimulus#GO:0048585;regulation of signal transduction#GO:0009966;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;regulation of DNA-templated transcription#GO:0006355;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;negative regulation of apoptotic signaling pathway#GO:2001234;regulation of apoptotic signaling pathway#GO:2001233;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of intrinsic apoptotic signaling pathway#GO:2001242 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cytosol#GO:0005829;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=8599|UniProtKB=Q96RD7 Q96RD7 PANX1 PTHR15759:SF5 PANNEXIN PANNEXIN-1 wide pore channel activity#GO:0022829;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 transport#GO:0006810;establishment of localization#GO:0051234;cell communication#GO:0007154;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;regulation of biological process#GO:0050789;biological regulation#GO:0065007;signaling#GO:0023052;cell-cell signaling#GO:0007267 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HUMAN|HGNC=9211|UniProtKB=Q16633 Q16633 POU2AF1 PTHR15363:SF3 POU DOMAIN CLASS 2-ASSOCIATING FACTOR 1 POU DOMAIN CLASS 2-ASSOCIATING FACTOR 1 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119 HUMAN|HGNC=13210|UniProtKB=Q9H0F7 Q9H0F7 ARL6 PTHR11711:SF21 ADP RIBOSYLATION FACTOR-RELATED ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 6 carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;ribonucleotide binding#GO:0032553;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;nucleotide binding#GO:0000166;ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265;anion binding#GO:0043168;small molecule binding#GO:0036094;binding#GO:0005488;guanyl nucleotide binding#GO:0019001;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525 cellular component assembly#GO:0022607;vesicle-mediated transport#GO:0016192;plasma membrane bounded cell projection organization#GO:0120036;macromolecule localization#GO:0033036;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;establishment of protein localization#GO:0045184;cell projection assembly#GO:0030031;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;plasma membrane bounded cell projection assembly#GO:0120031;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810;cell projection organization#GO:0030030;protein localization to organelle#GO:0033365;protein localization to cilium#GO:0061512;cellular component organization#GO:0016043;cilium assembly#GO:0060271;localization#GO:0051179;cellular localization#GO:0051641;protein transport#GO:0015031;cilium organization#GO:0044782;organelle assembly#GO:0070925 organelle#GO:0043226;ciliary plasm#GO:0097014;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;membraneless organelle#GO:0043228;axoneme#GO:0005930;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;cilium#GO:0005929;intracellular organelle#GO:0043229 G-protein#PC00020 HUMAN|HGNC=5996|UniProtKB=Q9NZN1 Q9NZN1 IL1RAPL1 PTHR11890:SF22 INTERLEUKIN-1 RECEPTOR FAMILY MEMBER INTERLEUKIN-1 RECEPTOR ACCESSORY PROTEIN-LIKE 1 cell surface receptor signaling pathway#GO:0007166;negative regulation of cellular process#GO:0048523;regulation of transport#GO:0051049;regulation of localization#GO:0032879;cellular process#GO:0009987;signal transduction#GO:0007165;biological regulation#GO:0065007;regulation of secretion by cell#GO:1903530;regulation of exocytosis#GO:0017157;regulation of secretion#GO:0051046;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;signaling#GO:0023052;regulation of cellular process#GO:0050794;negative regulation of transport#GO:0051051;response to stimulus#GO:0050896 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell surface#GO:0009986 transmembrane signal receptor#PC00197 HUMAN|HGNC=27977|UniProtKB=A4D161 A4D161 FAM221A PTHR31214:SF2 PROTEIN FAM221A-RELATED PROTEIN FAM221A HUMAN|HGNC=9485|UniProtKB=Q9Y6M0 Q9Y6M0 PRSS21 PTHR24256:SF578 TRYPTASE-RELATED TESTISIN endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;serine-type peptidase activity#GO:0008236 reproductive process#GO:0022414;gamete generation#GO:0007276;male gamete generation#GO:0048232;cellular process#GO:0009987;primary metabolic process#GO:0044238;developmental process involved in reproduction#GO:0003006;multicellular organismal reproductive process#GO:0048609;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;spermatogenesis#GO:0007283;developmental process#GO:0032502;sexual reproduction#GO:0019953;metabolic process#GO:0008152;proteolysis#GO:0006508 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 serine protease#PC00203 HUMAN|HGNC=17150|UniProtKB=Q9Y2V2 Q9Y2V2 CARHSP1 PTHR12962:SF3 CALCIUM-REGULATED HEAT STABLE PROTEIN CRHSP-24-RELATED CALCIUM-REGULATED HEAT-STABLE PROTEIN 1 nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;RNA binding#GO:0003723;mRNA 3'-UTR binding#GO:0003730 post-transcriptional regulation of gene expression#GO:0010608;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;regulation of mRNA metabolic process#GO:1903311;regulation of biosynthetic process#GO:0009889;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA stability#GO:0043487;regulation of biological quality#GO:0065008;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of mRNA catabolic process#GO:0061013;regulation of mRNA stability#GO:0043488;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031 HUMAN|HGNC=32950|UniProtKB=Q5VW00 Q5VW00 DCAF12L2 PTHR19860:SF8 DDB1- AND CUL4-ASSOCIATED FACTOR 12-RELATED DDB1- AND CUL4-ASSOCIATED FACTOR 12-LIKE PROTEIN 2 ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535;catalytic complex#GO:1902494;transferase complex#GO:1990234;Cul4-RING E3 ubiquitin ligase complex#GO:0080008 HUMAN|HGNC=12778|UniProtKB=O14904 O14904 WNT9A PTHR12027:SF75 WNT RELATED PROTEIN WNT-9A frizzled binding#GO:0005109;G protein-coupled receptor binding#GO:0001664;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;cytokine activity#GO:0005125;binding#GO:0005488;signaling receptor binding#GO:0005102;molecular function activator activity#GO:0140677;protein binding#GO:0005515 signaling#GO:0023052;regulation of cellular process#GO:0050794;Wnt signaling pathway#GO:0016055;response to stimulus#GO:0050896;cell differentiation#GO:0030154;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;system development#GO:0048731;cell fate commitment#GO:0045165;anatomical structure development#GO:0048856;canonical Wnt signaling pathway#GO:0060070;cell communication#GO:0007154;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;nervous system development#GO:0007399;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;cellular process#GO:0009987;signal transduction#GO:0007165;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;cell surface receptor signaling pathway#GO:0007166;neuron differentiation#GO:0030182;developmental process#GO:0032502 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 Wnt signaling pathway#P00057>Wnt#P01444;Alzheimer disease-presenilin pathway#P00004>Wnt#P00142;Cadherin signaling pathway#P00012>Wnt#P00474 HUMAN|HGNC=7|UniProtKB=P01023 P01023 A2M PTHR11412:SF165 MACROGLOBULIN / COMPLEMENT ALPHA-2-MACROGLOBULIN enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414;peptidase regulator activity#GO:0061134;endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772;enzyme inhibitor activity#GO:0004857 defense response#GO:0006952;response to stimulus#GO:0050896;inflammatory response#GO:0006954;response to stress#GO:0006950 extracellular region#GO:0005576;extracellular protein-containing complex#GO:0140392;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 protease inhibitor#PC00191 Blood coagulation#P00011>alpha2-macroglobulin#P00427 HUMAN|HGNC=2180|UniProtKB=O43405 O43405 COCH PTHR24020:SF36 COLLAGEN ALPHA COCHLIN sensory perception of sound#GO:0007605;multicellular organismal process#GO:0032501;system process#GO:0003008;sensory perception#GO:0007600;sensory perception of mechanical stimulus#GO:0050954;nervous system process#GO:0050877 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 extracellular matrix structural protein#PC00103 HUMAN|HGNC=25854|UniProtKB=Q9H841 Q9H841 NIPAL2 PTHR12570:SF16 DUF803 DOMAIN MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07070)-RELATED NIPA-LIKE PROTEIN 2 transport#GO:0006810;magnesium ion transport#GO:0015693;monoatomic ion transport#GO:0006811;metal ion transport#GO:0030001;establishment of localization#GO:0051234;localization#GO:0051179;monoatomic cation transport#GO:0006812 membrane#GO:0016020;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258 HUMAN|HGNC=14546|UniProtKB=Q9NRJ7 Q9NRJ7 PCDHB16 PTHR24028:SF318 CADHERIN-87A PROTOCADHERIN BETA-16 cell adhesion#GO:0007155;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cadherin#PC00057;cell adhesion molecule#PC00069 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HUMAN|HGNC=25801|UniProtKB=Q9H799 Q9H799 CPLANE1 PTHR14492:SF4 JBTS17 CILIOGENESIS AND PLANAR POLARITY EFFECTOR 1 cellular component assembly#GO:0022607;cell projection organization#GO:0030030;plasma membrane bounded cell projection organization#GO:0120036;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782;organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031 plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cilium#GO:0005929;ciliary transition zone#GO:0035869 HUMAN|HGNC=14049|UniProtKB=O60783 O60783 MRPS14 PTHR19836:SF31 30S RIBOSOMAL PROTEIN S14 SMALL RIBOSOMAL SUBUNIT PROTEIN US14M structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein biosynthetic process#GO:0160307;mitochondrial translation#GO:0032543;gene expression#GO:0010467;biosynthetic process#GO:0009058;metabolic process#GO:0008152;translation#GO:0006412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;mitochondrial gene expression#GO:0140053 ribosome#GO:0005840;mitochondrion#GO:0005739;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;small ribosomal subunit#GO:0015935;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;mitochondrial ribosome#GO:0005761;organellar ribosome#GO:0000313;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;membraneless organelle#GO:0043228;mitochondrial small ribosomal subunit#GO:0005763 ribosomal protein#PC00202 HUMAN|HGNC=12852|UniProtKB=P61981 P61981 YWHAG PTHR18860:SF22 14-3-3 PROTEIN 14-3-3 PROTEIN GAMMA binding#GO:0005488;kinase binding#GO:0019900;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;protein binding#GO:0005515 scaffold/adaptor protein#PC00226 FGF signaling pathway#P00021>14-3-3#P00624;EGF receptor signaling pathway#P00018>14-3-3#P00539;Parkinson disease#P00049>14-3-3#P01238 HUMAN|HGNC=28249|UniProtKB=Q8IUZ5 Q8IUZ5 PHYKPL PTHR45688:SF6 FAMILY NOT NAMED 5-PHOSPHOHYDROXY-L-LYSINE PHOSPHO-LYASE HUMAN|HGNC=22652|UniProtKB=Q5JPE7 Q5JPE7 NOMO2 PTHR23303:SF14 CARBOXYPEPTIDASE REGULATORY REGION-CONTAINING BOS COMPLEX SUBUNIT NOMO1-RELATED membrane#GO:0016020;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endoplasmic reticulum membrane#GO:0005789;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=26388|UniProtKB=Q6ZRI8 Q6ZRI8 ARHGAP36 PTHR12635:SF8 RHO-GTPASE-ACTIVATING PROTEIN 6 FAMILY MEMBER RHO GTPASE-ACTIVATING PROTEIN 36 GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme activator activity#GO:0008047 actin filament-based process#GO:0030029;actin filament organization#GO:0007015;supramolecular fiber organization#GO:0097435;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;actin cytoskeleton#GO:0015629;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165 G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HUMAN|HGNC=48953|UniProtKB=A4D0T7 A4D0T7 SMIM30 PTHR36878:SF1 SMALL INTEGRAL MEMBRANE PROTEIN 30 SMALL INTEGRAL MEMBRANE PROTEIN 30 HUMAN|HGNC=30899|UniProtKB=Q8N720 Q8N720 ZNF655 PTHR24377:SF284 IP01015P-RELATED ZINC FINGER PROTEIN 655 nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=27990|UniProtKB=Q5H9J7 Q5H9J7 BEX5 PTHR19430:SF0 PROTEIN BEX1-RELATED PROTEIN BEX5 protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 cell communication#GO:0007154;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=23797|UniProtKB=Q9BXR0 Q9BXR0 QTRT1 PTHR43530:SF1 QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1 QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1 pentosyltransferase activity#GO:0016763;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098;glycosyltransferase activity#GO:0016757 RNA metabolism protein#PC00031;RNA processing factor#PC00147 HUMAN|HGNC=11928|UniProtKB=O75888 O75888 TNFSF13 PTHR15151:SF12 PROTEIN EIGER TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 13 receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;cytokine activity#GO:0005125;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546 regulation of lymphocyte activation#GO:0051249;response to stimulus#GO:0050896;positive regulation of adaptive immune response#GO:0002821;regulation of biological process#GO:0050789;regulation of DNA metabolic process#GO:0051052;regulation of cell activation#GO:0050865;positive regulation of multicellular organismal process#GO:0051240;regulation of leukocyte activation#GO:0002694;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;immune system process#GO:0002376;regulation of lymphocyte mediated immunity#GO:0002706;regulation of DNA recombination#GO:0000018;regulation of multicellular organismal process#GO:0051239;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;positive regulation of immune system process#GO:0002684;regulation of B cell activation#GO:0050864;positive regulation of leukocyte activation#GO:0002696;regulation of developmental process#GO:0050793;regulation of macromolecule metabolic process#GO:0060255;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of leukocyte mediated immunity#GO:0002703;positive regulation of DNA metabolic process#GO:0051054;positive regulation of biosynthetic process#GO:0009891;positive regulation of lymphocyte mediated immunity#GO:0002708;positive regulation of lymphocyte activation#GO:0051251;regulation of immune effector process#GO:0002697;regulation of immune response#GO:0050776;biological regulation#GO:0065007;positive regulation of cell activation#GO:0050867;positive regulation of immune effector process#GO:0002699;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of response to stimulus#GO:0048584;immune response#GO:0006955;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of developmental process#GO:0051094;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;positive regulation of leukocyte mediated immunity#GO:0002705 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HUMAN|HGNC=12510|UniProtKB=Q9H347 Q9H347 UBQLN3 PTHR10677:SF4 UBIQUILIN UBIQUILIN-3 protein binding#GO:0005515;polyubiquitin modification-dependent protein binding#GO:0031593;binding#GO:0005488;modification-dependent protein binding#GO:0140030 protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238;catabolic process#GO:0009056 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 scaffold/adaptor protein#PC00226 HUMAN|HGNC=30060|UniProtKB=Q15155 Q15155 NOMO1 PTHR23303:SF14 CARBOXYPEPTIDASE REGULATORY REGION-CONTAINING BOS COMPLEX SUBUNIT NOMO1-RELATED cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane#GO:0016020;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789 HUMAN|HGNC=26148|UniProtKB=Q6UUV7 Q6UUV7 CRTC3 PTHR13589:SF4 CREB-REGULATED TRANSCRIPTION COACTIVATOR CREB-REGULATED TRANSCRIPTION COACTIVATOR 3 binding#GO:0005488;transcription factor binding#GO:0008134;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;transcription coactivator activity#GO:0003713;protein binding#GO:0005515;DNA-binding transcription factor binding#GO:0140297 cellular response to oxygen-containing compound#GO:1901701;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;response to chemical#GO:0042221;positive regulation of macromolecule metabolic process#GO:0010604;negative regulation of signal transduction#GO:0009968;positive regulation of transcription by RNA polymerase II#GO:0045944;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of signaling#GO:0023057;cellular response to chemical stimulus#GO:0070887;response to oxygen-containing compound#GO:1901700;regulation of signaling#GO:0023051;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;negative regulation of cell communication#GO:0010648;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of response to stimulus#GO:0048585;cellular response to nitrogen compound#GO:1901699;positive regulation of DNA-templated transcription#GO:0045893;regulation of signal transduction#GO:0009966;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of cellular process#GO:0048523;regulation of G protein-coupled receptor signaling pathway#GO:0008277;regulation of response to stimulus#GO:0048583;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of G protein-coupled receptor signaling pathway#GO:0045744;cellular response to stimulus#GO:0051716;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;response to nitrogen compound#GO:1901698;regulation of RNA metabolic process#GO:0051252 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 transcription cofactor#PC00217;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=20991|UniProtKB=Q8NB25 Q8NB25 FAM184A PTHR18870:SF7 PROTEIN TAG-278-RELATED PROTEIN FAM184A HUMAN|HGNC=13581|UniProtKB=Q9UK22 Q9UK22 FBXO2 PTHR12125:SF11 F-BOX ONLY PROTEIN 6-LIKE PROTEIN F-BOX ONLY PROTEIN 2 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=11623|UniProtKB=Q99081 Q99081 TCF12 PTHR11793:SF11 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR TRANSCRIPTION FACTOR 12 RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 chromosome#GO:0005694;chromatin#GO:0000785;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;transcription regulator complex#GO:0005667;intracellular anatomical structure#GO:0005622 basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=5329|UniProtKB=P10997 P10997 IAPP PTHR10505:SF4 CALCITONIN-RELATED ISLET AMYLOID POLYPEPTIDE cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 peptide hormone#PC00179 HUMAN|HGNC=24283|UniProtKB=Q4FZB7 Q4FZB7 KMT5B PTHR12977:SF12 SUPPRESSOR OF VARIEGATION 4-20-RELATED HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B protein methyltransferase activity#GO:0008276;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a protein#GO:0140096;protein-lysine N-methyltransferase activity#GO:0016279;histone methyltransferase activity#GO:0042054;N-methyltransferase activity#GO:0008170;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;lysine N-methyltransferase activity#GO:0016278;histone modifying activity#GO:0140993 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=13520|UniProtKB=Q14696 Q14696 MESD PTHR17600:SF3 MESODERM DEVELOPMENT CANDIDATE 2 LRP CHAPERONE MESD protein binding#GO:0005515;lipoprotein particle receptor binding#GO:0070325;binding#GO:0005488;signaling receptor binding#GO:0005102 HUMAN|HGNC=11655|UniProtKB=P17987 P17987 TCP1 PTHR11353:SF192 CHAPERONIN T-COMPLEX PROTEIN 1 SUBUNIT ALPHA protein folding#GO:0006457;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152 protein folding chaperone complex#GO:0101031;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;chaperonin-containing T-complex#GO:0005832;cytosol#GO:0005829;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 chaperonin#PC00073 HUMAN|HGNC=26638|UniProtKB=Q6NVH7 Q6NVH7 SWSAP1 PTHR28653:SF1 FAMILY NOT NAMED ATPASE SWSAP1 HUMAN|HGNC=28691|UniProtKB=P60002 P60002 ELOF1 PTHR20934:SF0 TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG RNA polymerase binding#GO:0070063;enzyme binding#GO:0019899;binding#GO:0005488;RNA polymerase core enzyme binding#GO:0043175;protein binding#GO:0005515;RNA polymerase II complex binding#GO:0000993 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;DNA-templated transcription elongation#GO:0006354;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;transcription elongation by RNA polymerase II#GO:0006368;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;transcription by RNA polymerase II#GO:0006366;macromolecule metabolic process#GO:0043170 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;transcription elongation factor complex#GO:0008023;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 HUMAN|HGNC=44318|UniProtKB=C9JSJ3 C9JSJ3 MEIOSIN PTHR47658:SF1 HIGH MOBILITY GROUP B PROTEIN 12-RELATED MEIOSIS INITIATOR PROTEIN HUMAN|HGNC=24971|UniProtKB=Q9P127 Q9P127 LUZP4 PTHR22550:SF5 SPORE GERMINATION PROTEIN LEUCINE ZIPPER PROTEIN 4 HUMAN|HGNC=37210|UniProtKB=B7Z1M9 B7Z1M9 C2CD4D PTHR46291:SF1 C2 DOMAIN-CONTAINING PROTEIN C2 CALCIUM-DEPENDENT DOMAIN-CONTAINING PROTEIN 4D HUMAN|HGNC=12020|UniProtKB=O60507 O60507 TPST1 PTHR12788:SF4 PROTEIN-TYROSINE SULFOTRANSFERASE 2 PROTEIN-TYROSINE SULFOTRANSFERASE 1 transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring sulphur-containing groups#GO:0016782;sulfotransferase activity#GO:0008146 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 transferase#PC00220 CCKR signaling map#P06959>Protein tyrosine sulfotransferase#P07148 HUMAN|HGNC=20512|UniProtKB=Q5PSV4 Q5PSV4 BRMS1L PTHR21964:SF16 BREAST CANCER METASTASIS-SUPPRESSOR 1 BREAST CANCER METASTASIS-SUPPRESSOR 1-LIKE PROTEIN enzyme binding#GO:0019899;binding#GO:0005488;histone deacetylase binding#GO:0042826;protein binding#GO:0005515 regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007 Sin3-type complex#GO:0070822;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;nucleus#GO:0005634;chromatin#GO:0000785;histone deacetylase complex#GO:0000118;membrane-enclosed lumen#GO:0031974;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991 HUMAN|HGNC=29838|UniProtKB=Q9UHB4 Q9UHB4 NDOR1 PTHR19384:SF10 NITRIC OXIDE SYNTHASE-RELATED NADPH-DEPENDENT DIFLAVIN OXIDOREDUCTASE 1 catalytic activity#GO:0003824;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;oxidoreductase activity#GO:0016491;heterocyclic compound binding#GO:1901363;nucleotide binding#GO:0000166;anion binding#GO:0043168;small molecule binding#GO:0036094;flavin adenine dinucleotide binding#GO:0050660;binding#GO:0005488;ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HUMAN|HGNC=11848|UniProtKB=O60603 O60603 TLR2 PTHR24365:SF17 TOLL-LIKE RECEPTOR TOLL-LIKE RECEPTOR 2 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;lipid binding#GO:0008289;binding#GO:0005488 positive regulation of immune system process#GO:0002684;signal transduction#GO:0007165;activation of immune response#GO:0002253;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of response to external stimulus#GO:0032101;immune response-activating signaling pathway#GO:0002757;positive regulation of response to external stimulus#GO:0032103;toll-like receptor signaling pathway#GO:0002224;regulation of biological process#GO:0050789;immune response-regulating signaling pathway#GO:0002764;response to stimulus#GO:0050896;signaling#GO:0023052;immune system process#GO:0002376;activation of innate immune response#GO:0002218;positive regulation of innate immune response#GO:0045089;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of response to stress#GO:0080134;positive regulation of defense response#GO:0031349;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;regulation of innate immune response#GO:0045088;positive regulation of response to biotic stimulus#GO:0002833;pattern recognition receptor signaling pathway#GO:0002221;innate immune response-activating signaling pathway#GO:0002758;cellular response to stimulus#GO:0051716;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of response to biotic stimulus#GO:0002831;regulation of immune response#GO:0050776;regulation of defense response#GO:0031347;cell communication#GO:0007154 signaling receptor complex#GO:0043235;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 Toll receptor signaling pathway#P00054>TLR2,4,7#P01351;Toll receptor signaling pathway#P00054>TLR1,2,6#P01380;Toll receptor signaling pathway#P00054>TLR#P01346 HUMAN|HGNC=53638|UniProtKB=A0A1B0GV85 A0A1B0GV85 REELD1 PTHR45828:SF51 CYTOCHROME B561/FERRIC REDUCTASE TRANSMEMBRANE REELIN DOMAIN-CONTAINING PROTEIN 1 cellular anatomical structure#GO:0110165;membrane#GO:0016020 reductase#PC00198;oxidoreductase#PC00176 HUMAN|HGNC=37213|UniProtKB=C9JXX5 C9JXX5 FREY1 PTHR37872:SF1 SIMILAR TO RIKEN CDNA 1700029I15 PROTEIN FREY 1 multicellular organismal reproductive process#GO:0048609;cell-cell recognition#GO:0009988;sperm-egg recognition#GO:0035036;sexual reproduction#GO:0019953;cell recognition#GO:0008037;cellular process involved in reproduction in multicellular organism#GO:0022412;reproductive process#GO:0022414;fertilization#GO:0009566;single fertilization#GO:0007338;fusion of sperm to egg plasma membrane involved in single fertilization#GO:0007342;cellular process#GO:0009987 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175 HUMAN|HGNC=5901|UniProtKB=A0A075B6K0 A0A075B6K0 IGLV3-16 PTHR23267:SF471 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN LAMBDA VARIABLE 3-16 response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=10930|UniProtKB=O00624 O00624 SLC17A2 PTHR11662:SF193 SOLUTE CARRIER FAMILY 17 SODIUM-DEPENDENT PHOSPHATE TRANSPORT PROTEIN 3 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;cell periphery#GO:0071944;apical part of cell#GO:0045177;membrane#GO:0016020;apical plasma membrane#GO:0016324 secondary carrier transporter#PC00258 HUMAN|HGNC=30224|UniProtKB=Q9HAB3 Q9HAB3 SLC52A2 PTHR12929:SF1 SOLUTE CARRIER FAMILY 52 SOLUTE CARRIER FAMILY 52, RIBOFLAVIN TRANSPORTER, MEMBER 2 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 nitrogen compound transport#GO:0071705;transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;vitamin transport#GO:0051180 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 secondary carrier transporter#PC00258 HUMAN|Gene=ENH1_HUMAN|UniProtKB=Q9N2K0 Q9N2K0 PTHR10424:SF75 VIRAL ENVELOPE PROTEIN ENDOGENOUS RETROVIRUS GROUP S71 MEMBER 1 ENV POLYPROTEIN-RELATED muscle structure development#GO:0061061;cell differentiation#GO:0030154;myoblast fusion#GO:0007520;cellular process#GO:0009987;muscle cell differentiation#GO:0042692;cellular developmental process#GO:0048869;anatomical structure development#GO:0048856;syncytium formation by cell-cell fusion#GO:0000768;striated muscle cell differentiation#GO:0051146;animal gross anatomical part developmental process#GO:0160108;cell-cell fusion#GO:0140253;developmental process#GO:0032502 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 viral or transposable element protein#PC00237 HUMAN|HGNC=14047|UniProtKB=Q9Y2R5 Q9Y2R5 MRPS17 PTHR24088:SF2 28S RIBOSOMAL PROTEIN S17, MITOCHONDRIAL SMALL RIBOSOMAL SUBUNIT PROTEIN US17M intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;ribosome#GO:0005840;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;mitochondrial ribosome#GO:0005761;organellar ribosome#GO:0000313;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;small ribosomal subunit#GO:0015935;mitochondrial matrix#GO:0005759;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;membrane-enclosed lumen#GO:0031974;membraneless organelle#GO:0043228;mitochondrial small ribosomal subunit#GO:0005763 ribosomal protein#PC00202 HUMAN|HGNC=21699|UniProtKB=Q49MI3 Q49MI3 CERKL PTHR12358:SF26 SPHINGOSINE KINASE CERAMIDE KINASE-LIKE PROTEIN catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;lipid kinase activity#GO:0001727 regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;negative regulation of programmed cell death#GO:0043069;regulation of biological process#GO:0050789;negative regulation of apoptotic process#GO:0043066;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;regulation of apoptotic process#GO:0042981 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 kinase#PC00137;metabolite interconversion enzyme#PC00262;transferase#PC00220 HUMAN|HGNC=13602|UniProtKB=Q9UKA1 Q9UKA1 FBXL5 PTHR13318:SF19 PARTNER OF PAIRED, ISOFORM B-RELATED F-BOX_LRR-REPEAT PROTEIN 5 catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163 SCF ubiquitin ligase complex#GO:0019005;intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;transferase complex#GO:1990234;catalytic complex#GO:1902494 HUMAN|HGNC=32272|UniProtKB=P0C7X0 P0C7X0 FAM90A24 PTHR16035:SF14 PROTEIN FAM90A1 PROTEIN FAM90A10-RELATED HUMAN|HGNC=25498|UniProtKB=Q6B0I6 Q6B0I6 KDM4D PTHR10694:SF21 LYSINE-SPECIFIC DEMETHYLASE LYSINE-SPECIFIC DEMETHYLASE 4D catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;histone demethylase activity#GO:0032452;oxidoreductase activity#GO:0016491;demethylase activity#GO:0032451;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;catalytic activity, acting on a protein#GO:0140096;protein demethylase activity#GO:0140457;dioxygenase activity#GO:0051213;histone modifying activity#GO:0140993 regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;cellular component organization#GO:0016043;cellular process#GO:0009987;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;chromatin remodeling#GO:0006338;biological regulation#GO:0065007;chromatin organization#GO:0006325 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226 histone modifying enzyme#PC00261 HUMAN|HGNC=30252|UniProtKB=Q93015 Q93015 NAA80 PTHR13538:SF4 N-ACETYLTRANSFERASE 6 N-ALPHA-ACETYLTRANSFERASE 80 catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acyltransferase activity#GO:0016746;ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;N-acetyltransferase activity#GO:0008080;transferase activity#GO:0016740;heterocyclic compound binding#GO:1901363;protein-N-terminal amino-acid acetyltransferase activity#GO:0004596;protein N-acetyltransferase activity#GO:0034212;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;acetyltransferase activity#GO:0016407;protein N-acyltransferase activity#GO:0140186 regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;cellular component organization#GO:0016043;regulation of supramolecular fiber organization#GO:1902903;regulation of cellular component size#GO:0032535;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;regulation of biological quality#GO:0065008;regulation of actin filament length#GO:0030832;biological regulation#GO:0065007;regulation of actin polymerization or depolymerization#GO:0008064;regulation of actin cytoskeleton organization#GO:0032956;regulation of actin filament organization#GO:0110053;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;regulation of anatomical structure size#GO:0090066;regulation of actin filament-based process#GO:0032970 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 transferase#PC00220;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=18561|UniProtKB=Q8TDH9 Q8TDH9 BLOC1S5 PTHR31784:SF2 BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 5 BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 5 cellular localization#GO:0051641;microtubule-based transport#GO:0099111;establishment of organelle localization#GO:0051656;response to stimulus#GO:0050896;cell differentiation#GO:0030154;microtubule-based process#GO:0007017;organelle transport along microtubule#GO:0072384;cellular pigmentation#GO:0033059;establishment of vesicle localization#GO:0051650;synaptic vesicle localization#GO:0097479;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;developmental pigmentation#GO:0048066;establishment of localization in cell#GO:0051649;synaptic vesicle transport#GO:0048489;anterograde axonal transport#GO:0008089;localization#GO:0051179;pigmentation#GO:0043473;organelle localization#GO:0051640;axonal transport#GO:0098930;microtubule-based movement#GO:0007018;cellular response to stimulus#GO:0051716;response to external stimulus#GO:0009605;anterograde synaptic vesicle transport#GO:0048490;vesicle cytoskeletal trafficking#GO:0099518;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;cellular developmental process#GO:0048869;transport#GO:0006810;developmental process#GO:0032502;intracellular transport#GO:0046907;vesicle transport along microtubule#GO:0047496;cytoskeleton-dependent intracellular transport#GO:0030705;developmental maturation#GO:0021700;vesicle localization#GO:0051648;axo-dendritic transport#GO:0008088 protein-containing complex#GO:0032991;intracellular protein-containing complex#GO:0140535;BLOC-1 complex#GO:0031083 HUMAN|HGNC=6888|UniProtKB=Q16644 Q16644 MAPKAPK3 PTHR24349:SF64 SERINE/THREONINE-PROTEIN KINASE MAP KINASE-ACTIVATED PROTEIN KINASE 3 transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;calcium/calmodulin-dependent protein kinase activity#GO:0004683;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;protein serine/threonine kinase activity#GO:0004674;kinase binding#GO:0019900;binding#GO:0005488;protein kinase activity#GO:0004672;protein binding#GO:0005515;phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;calmodulin binding#GO:0005516;transferase activity#GO:0016740;mitogen-activated protein kinase binding#GO:0051019 response to peptide#GO:1901652;immune system process#GO:0002376;response to stimulus#GO:0050896;signaling#GO:0023052;toll-like receptor signaling pathway#GO:0002224;regulation of biological process#GO:0050789;immune response-regulating signaling pathway#GO:0002764;immune response-activating signaling pathway#GO:0002757;positive regulation of response to external stimulus#GO:0032103;response to chemical#GO:0042221;response to cytokine#GO:0034097;regulation of response to external stimulus#GO:0032101;positive regulation of immune system process#GO:0002684;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;signal transduction#GO:0007165;cellular process#GO:0009987;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of immune response#GO:0050776;regulation of defense response#GO:0031347;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of response to biotic stimulus#GO:0002831;innate immune response-activating signaling pathway#GO:0002758;cellular response to stimulus#GO:0051716;regulation of innate immune response#GO:0045088;positive regulation of response to biotic stimulus#GO:0002833;pattern recognition receptor signaling pathway#GO:0002221;regulation of response to stress#GO:0080134;positive regulation of immune response#GO:0050778;positive regulation of defense response#GO:0031349;regulation of response to stimulus#GO:0048583;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;activation of innate immune response#GO:0002218;positive regulation of innate immune response#GO:0045089 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Angiogenesis#P00005>MAPKAPK2/3#P00244;p38 MAPK pathway#P05918>MAPKAP-K3#P05919;VEGF signaling pathway#P00056>MAPKAPK2/3#P01415;Ras Pathway#P04393>MAPKAP#P04564 HUMAN|HGNC=25309|UniProtKB=Q6P2H3 Q6P2H3 CEP85 PTHR31075:SF3 CENTROSOMAL PROTEIN OF 85 KDA CENTROSOMAL PROTEIN OF 85 KDA microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;microtubule organizing center#GO:0005815;centrosome#GO:0005813;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 HUMAN|HGNC=29831|UniProtKB=O95544 O95544 NADK PTHR20275:SF44 NAD KINASE NAD KINASE phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;nicotinamide nucleotide metabolic process#GO:0046496;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;NAD+ metabolic process#GO:0019674;NADP+ metabolic process#GO:0006739;nucleobase-containing small molecule metabolic process#GO:0055086;nucleoside phosphate biosynthetic process#GO:1901293;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;nucleotide biosynthetic process#GO:0009165;nucleotide metabolic process#GO:0009117;organophosphate biosynthetic process#GO:0090407;pyridine-containing compound metabolic process#GO:0072524;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 nucleotide kinase#PC00172 HUMAN|HGNC=25833|UniProtKB=Q6ZUS5 Q6ZUS5 CCDC121 PTHR14845:SF9 COILED-COIL DOMAIN-CONTAINING 166 COILED-COIL DOMAIN-CONTAINING PROTEIN 121 HUMAN|HGNC=6130|UniProtKB=Q96AZ6 Q96AZ6 ISG20 PTHR12801:SF59 RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED INTERFERON-STIMULATED GENE 20 KDA PROTEIN catalytic activity#GO:0003824;exonuclease activity#GO:0004527;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;nuclease activity#GO:0004518 RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;macromolecule catabolic process#GO:0009057;nucleobase-containing compound biosynthetic process#GO:0034654;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;defense response to virus#GO:0051607;negative regulation of biological process#GO:0048519;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA catabolic process#GO:0006401;DNA catabolic process#GO:0006308;biosynthetic process#GO:0009058;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;response to other organism#GO:0051707;macromolecule biosynthetic process#GO:0009059;nucleic acid catabolic process#GO:0141188;nucleobase-containing compound catabolic process#GO:0034655;response to external stimulus#GO:0009605;defense response#GO:0006952;macromolecule metabolic process#GO:0043170;RNA biosynthetic process#GO:0032774;response to external biotic stimulus#GO:0043207;catabolic process#GO:0009056;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;response to virus#GO:0009615 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031;exoribonuclease#PC00099 HUMAN|HGNC=9377|UniProtKB=P54646 P54646 PRKAA2 PTHR24343:SF303 SERINE/THREONINE KINASE 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-2 protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740 intracellular protein localization#GO:0008104;regulation of TORC1 signaling#GO:1903432;regulation of catabolic process#GO:0009894;positive regulation of catabolic process#GO:0009896;cellular response to nutrient levels#GO:0031669;regulation of response to stimulus#GO:0048583;cellular response to starvation#GO:0009267;negative regulation of cellular process#GO:0048523;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of response to stimulus#GO:0048585;positive regulation of cellular process#GO:0048522;cellular response to glucose starvation#GO:0042149;response to nutrient levels#GO:0031667;macromolecule localization#GO:0033036;regulation of metabolic process#GO:0019222;localization#GO:0051179;regulation of cell communication#GO:0010646;negative regulation of TOR signaling#GO:0032007;protein localization to organelle#GO:0033365;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;response to starvation#GO:0042594;negative regulation of TORC1 signaling#GO:1904262;negative regulation of signal transduction#GO:0009968;positive regulation of biological process#GO:0048518;regulation of TOR signaling#GO:0032006;cellular process#GO:0009987;positive regulation of autophagy#GO:0010508;response to stress#GO:0006950;negative regulation of cell communication#GO:0010648;positive regulation of metabolic process#GO:0009893;negative regulation of intracellular signal transduction#GO:1902532;cellular response to stress#GO:0033554;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of autophagy#GO:0010506 nucleus#GO:0005634;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex#GO:1990234;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;protein kinase complex#GO:1902911;membrane-bounded organelle#GO:0043227 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 p53 pathway by glucose deprivation#P04397>AMPK#P04639 HUMAN|HGNC=24276|UniProtKB=Q9Y512 Q9Y512 SAMM50 PTHR12815:SF18 SORTING AND ASSEMBLY MACHINERY SAMM50 PROTEIN FAMILY MEMBER SORTING AND ASSEMBLY MACHINERY COMPONENT 50 HOMOLOG protein localization to mitochondrion#GO:0070585;cellular component organization#GO:0016043;protein localization to organelle#GO:0033365;localization within membrane#GO:0051668;protein insertion into mitochondrial outer membrane#GO:0045040;localization#GO:0051179;cellular localization#GO:0051641;mitochondrial membrane organization#GO:0007006;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule localization#GO:0033036;establishment of protein localization to membrane#GO:0090150;organelle organization#GO:0006996;mitochondrion organization#GO:0007005;membrane organization#GO:0061024;protein insertion into membrane#GO:0051205;intracellular protein localization#GO:0008104;establishment of protein localization to organelle#GO:0072594;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234 organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;mitochondrial outer membrane#GO:0005741;mitochondrial outer membrane translocase complex#GO:0005742;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;organelle outer membrane#GO:0031968;mitochondrial protein-containing complex#GO:0098798;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;outer membrane#GO:0019867;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;organelle envelope#GO:0031967;membrane protein complex#GO:0098796 HUMAN|HGNC=29180|UniProtKB=Q9UPV7 Q9UPV7 PHF24 PTHR46453:SF4 PROTEIN KINASE C-BINDING PROTEIN 1 PHD FINGER PROTEIN 24 transcription regulator activity#GO:0140110;transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 HUMAN|HGNC=18191|UniProtKB=Q9C0I1 Q9C0I1 MTMR12 PTHR10807:SF37 MYOTUBULARIN-RELATED MYOTUBULARIN-RELATED PROTEIN 12 catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578 lipid modification#GO:0030258;dephosphorylation#GO:0016311;phosphatidylinositol dephosphorylation#GO:0046856;metabolic process#GO:0008152;phosphatidylinositol metabolic process#GO:0046488;lipid metabolic process#GO:0006629;glycerophospholipid metabolic process#GO:0006650;glycerolipid metabolic process#GO:0046486;phospholipid metabolic process#GO:0006644;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;organophosphate metabolic process#GO:0019637;phosphate-containing compound metabolic process#GO:0006796;cellular process#GO:0009987;phospholipid dephosphorylation#GO:0046839 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;membrane#GO:0016020 phosphatase#PC00181 HUMAN|HGNC=8075|UniProtKB=Q9H1B4 Q9H1B4 NXF5 PTHR10662:SF15 NUCLEAR RNA EXPORT FACTOR NUCLEAR RNA EXPORT FACTOR 5 binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 nucleobase-containing compound transport#GO:0015931;RNA transport#GO:0050658;RNA localization#GO:0006403;establishment of RNA localization#GO:0051236;mRNA transport#GO:0051028;localization#GO:0051179;nucleic acid transport#GO:0050657;mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;nuclear transport#GO:0051169;nuclear export#GO:0051168;nucleocytoplasmic transport#GO:0006913;gene expression#GO:0010467;biosynthetic process#GO:0009058;macromolecule localization#GO:0033036;nitrogen compound transport#GO:0071705;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;poly(A)+ mRNA export from nucleus#GO:0016973;establishment of localization#GO:0051234;metabolic process#GO:0008152;RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907;transport#GO:0006810 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 RNA metabolism protein#PC00031 HUMAN|HGNC=7139|UniProtKB=P98177 P98177 FOXO4 PTHR45767:SF3 FORKHEAD BOX PROTEIN O FORKHEAD BOX PROTEIN O4 double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 winged helix/forkhead transcription factor#PC00246 PI3 kinase pathway#P00048>FOXO#P01198 HUMAN|HGNC=30882|UniProtKB=Q9NZ43 Q9NZ43 USE1 PTHR13050:SF10 USE1-LIKE PROTEIN VESICLE TRANSPORT PROTEIN USE1 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;SNAP receptor activity#GO:0005484 establishment of localization#GO:0051234;vesicle-mediated transport#GO:0016192;localization#GO:0051179;Golgi vesicle transport#GO:0048193;cellular process#GO:0009987;transport#GO:0006810;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890 organelle#GO:0043226;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;SNARE complex#GO:0031201;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane protein complex#GO:0098796;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 HUMAN|HGNC=29267|UniProtKB=Q5MIZ7 Q5MIZ7 PPP4R3B PTHR23318:SF18 ATP SYNTHASE GAMMA-RELATED SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 3B enzyme regulator activity#GO:0030234;phosphatase regulator activity#GO:0019208;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;phosphatase activator activity#GO:0019211;protein phosphatase regulator activity#GO:0019888;enzyme activator activity#GO:0008047 biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;response to stress#GO:0006950;regulation of metabolic process#GO:0019222;DNA damage response#GO:0006974;regulation of DNA repair#GO:0006282;regulation of response to stimulus#GO:0048583;regulation of response to stress#GO:0080134;regulation of macromolecule metabolic process#GO:0060255;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of DNA metabolic process#GO:0051052;cellular response to stimulus#GO:0051716;regulation of double-strand break repair#GO:2000779;regulation of cellular response to stress#GO:0080135;cellular response to stress#GO:0033554 nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleoplasm#GO:0005654;protein serine/threonine phosphatase complex#GO:0008287;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 ATP synthase#PC00002 HUMAN|HGNC=5800|UniProtKB=A0A075B6S2 A0A075B6S2 IGKV2D-29 PTHR23267:SF380 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN KAPPA VARIABLE 2D-29 immune system process#GO:0002376;immune response#GO:0006955;response to stimulus#GO:0050896 protein-containing complex#GO:0032991 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=41979|UniProtKB=E9PIF3 E9PIF3 NPIPA2 PTHR15438:SF5 NUCLEAR PORE COMPLEX INTERACTING PROTEIN NUCLEAR PORE COMPLEX INTERACTING PROTEIN FAMILY MEMBER B3-RELATED HUMAN|HGNC=11256|UniProtKB=Q13103 Q13103 SPP2 PTHR15444:SF4 SECRETED PHOSPHOPROTEIN 24 SECRETED PHOSPHOPROTEIN 24 HUMAN|HGNC=19125|UniProtKB=Q96M96 Q96M96 FGD4 PTHR12673:SF98 FACIOGENITAL DYSPLASIA PROTEIN FYVE, RHOGEF AND PH DOMAIN-CONTAINING PROTEIN 4 guanyl-nucleotide exchange factor activity#GO:0005085;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton organization#GO:0007010;cell projection organization#GO:0030030;cellular component assembly#GO:0022607;filopodium assembly#GO:0046847;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection assembly#GO:0120031 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 G-protein modulator#PC00022;guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=23498|UniProtKB=Q86YQ8 Q86YQ8 CPNE8 PTHR10857:SF133 COPINE COPINE-8 phospholipid binding#GO:0005543;binding#GO:0005488;lipid binding#GO:0008289 response to metal ion#GO:0010038;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cellular response to chemical stimulus#GO:0070887;response to stimulus#GO:0050896;response to calcium ion#GO:0051592;response to chemical#GO:0042221 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 calcium-binding protein#PC00060 HUMAN|HGNC=26398|UniProtKB=Q96NN9 Q96NN9 AIFM3 PTHR43557:SF8 APOPTOSIS-INDUCING FACTOR 1 APOPTOSIS-INDUCING FACTOR 3 oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on NAD(P)H#GO:0016651;catalytic activity#GO:0003824 programmed cell death#GO:0012501;execution phase of apoptosis#GO:0097194;cellular process#GO:0009987;apoptotic process#GO:0006915;cell death#GO:0008219 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739 oxidoreductase#PC00176 HUMAN|HGNC=4515|UniProtKB=P46095 P46095 GPR6 PTHR22750:SF19 G-PROTEIN COUPLED RECEPTOR G PROTEIN-COUPLED RECEPTOR 6 bioactive lipid receptor activity#GO:0045125;transmembrane signaling receptor activity#GO:0004888;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188 plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021 HUMAN|HGNC=15875|UniProtKB=Q9NUS5 Q9NUS5 AP5S1 PTHR16120:SF0 AP-5 COMPLEX SUBUNIT SIGMA-1 AP-5 COMPLEX SUBUNIT SIGMA-1 endosomal transport#GO:0016197;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;transport#GO:0006810;intracellular transport#GO:0046907;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;cellular process#GO:0009987 cytosol#GO:0005829;membrane#GO:0016020;vacuole#GO:0005773;cytoplasm#GO:0005737;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;late endosome#GO:0005770;AP-type membrane coat adaptor complex#GO:0030119;lytic vacuole#GO:0000323;vesicle#GO:0031982;lysosome#GO:0005764;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;coated membrane#GO:0048475;membrane coat#GO:0030117 HUMAN|HGNC=28194|UniProtKB=Q9BRP1 Q9BRP1 PDCD2L PTHR46421:SF1 PROGRAMMED CELL DEATH PROTEIN 2-LIKE US5 ASSEMBLY CHAPERONE PDCD2L programmed cell death#GO:0012501;cell death#GO:0008219;cellular process#GO:0009987;apoptotic process#GO:0006915 HUMAN|HGNC=19382|UniProtKB=O14508 O14508 SOCS2 PTHR10155:SF7 PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT SUPPRESSOR OF CYTOKINE SIGNALING 2 protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488;cytokine receptor binding#GO:0005126 signal transduction#GO:0007165;cellular process#GO:0009987;response to chemical#GO:0042221;response to cytokine#GO:0034097;negative regulation of response to stimulus#GO:0048585;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of signal transduction#GO:0009968;negative regulation of cellular process#GO:0048523;cell surface receptor signaling pathway#GO:0007166;regulation of receptor signaling pathway via JAK-STAT#GO:0046425;regulation of response to stimulus#GO:0048583;negative regulation of biological process#GO:0048519;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of receptor signaling pathway via STAT#GO:1904892;regulation of cell communication#GO:0010646;negative regulation of signaling#GO:0023057;cytokine-mediated signaling pathway#GO:0019221;regulation of signaling#GO:0023051;cell communication#GO:0007154;response to peptide#GO:1901652;negative regulation of cell communication#GO:0010648 kinase modulator#PC00140 Interferon-gamma signaling pathway#P00035>SOCS#P00956 HUMAN|HGNC=6166|UniProtKB=P19827 P19827 ITIH1 PTHR10338:SF106 INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H1 protease inhibitor#PC00191;protein-binding activity modulator#PC00095 HUMAN|HGNC=13538|UniProtKB=Q96L34 Q96L34 MARK4 PTHR24346:SF28 MAP/MICROTUBULE AFFINITY-REGULATING KINASE MAP_MICROTUBULE AFFINITY-REGULATING KINASE 4 transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=7546|UniProtKB=Q9BQG0 Q9BQG0 MYBBP1A PTHR13213:SF3 MYB-BINDING PROTEIN 1A FAMILY MEMBER MYB-BINDING PROTEIN 1A DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=17044|UniProtKB=Q8N8Q9 Q8N8Q9 NIPA2 PTHR12570:SF1 DUF803 DOMAIN MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07070)-RELATED MAGNESIUM TRANSPORTER NIPA2 magnesium ion transport#GO:0015693;transport#GO:0006810;localization#GO:0051179;monoatomic cation transport#GO:0006812;establishment of localization#GO:0051234;metal ion transport#GO:0030001;monoatomic ion transport#GO:0006811 membrane#GO:0016020;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258 HUMAN|HGNC=8095|UniProtKB=P54368 P54368 OAZ1 PTHR10279:SF8 ORNITHINE DECARBOXYLASE ANTIZYME ORNITHINE DECARBOXYLASE ANTIZYME 1 enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;molecular function inhibitor activity#GO:0140678;enzyme inhibitor activity#GO:0004857 nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 protein-binding activity modulator#PC00095 HUMAN|HGNC=24162|UniProtKB=Q9BW30 Q9BW30 TPPP3 PTHR12932:SF16 P25 ALPHA-RELATED TUBULIN POLYMERIZATION-PROMOTING PROTEIN FAMILY MEMBER 3 protein binding#GO:0005515;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631 organelle organization#GO:0006996;microtubule polymerization or depolymerization#GO:0031109;cellular component biogenesis#GO:0044085;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;positive regulation of protein polymerization#GO:0032273;cellular component assembly#GO:0022607;positive regulation of cellular component biogenesis#GO:0044089;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;cellular component organization or biogenesis#GO:0071840;microtubule polymerization#GO:0046785;protein-containing complex organization#GO:0043933;microtubule-based process#GO:0007017;cellular component organization#GO:0016043;regulation of protein-containing complex assembly#GO:0043254;protein-containing complex assembly#GO:0065003;regulation of biological process#GO:0050789;protein polymerization#GO:0051258;regulation of protein polymerization#GO:0032271;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of cellular component biogenesis#GO:0044087;positive regulation of cellular component organization#GO:0051130;microtubule bundle formation#GO:0001578;microtubule cytoskeleton organization#GO:0000226;supramolecular fiber organization#GO:0097435 cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;organelle#GO:0043226;supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 non-motor microtubule binding protein#PC00166 HUMAN|HGNC=29451|UniProtKB=Q9BYJ0 Q9BYJ0 FGFBP2 PTHR15258:SF1 FGF BINDING PROTEIN-RELATED FIBROBLAST GROWTH FACTOR-BINDING PROTEIN 2 protein binding#GO:0005515;growth factor binding#GO:0019838;binding#GO:0005488 cellular process#GO:0009987;regulation of biological process#GO:0050789;cell communication#GO:0007154;signaling#GO:0023052;cell-cell signaling#GO:0007267;biological regulation#GO:0065007 HUMAN|HGNC=10050|UniProtKB=Q05823 Q05823 RNASEL PTHR24141:SF4 2-5A-DEPENDENT RIBONUCLEASE 2-5A-DEPENDENT RIBONUCLEASE nucleic acid binding#GO:0003676;binding#GO:0005488;nuclease activity#GO:0004518;RNA binding#GO:0003723;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;RNA nuclease activity#GO:0004540;catalytic activity, acting on RNA#GO:0140098 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;response to other organism#GO:0051707;biological regulation#GO:0065007;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;defense response#GO:0006952;response to external stimulus#GO:0009605;macromolecule metabolic process#GO:0043170;regulation of biological process#GO:0050789;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;negative regulation of biological process#GO:0048519;defense response to virus#GO:0051607;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;RNA biosynthetic process#GO:0032774;response to stimulus#GO:0050896;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;response to virus#GO:0009615 endoribonuclease#PC00094 HUMAN|HGNC=20954|UniProtKB=Q9NP79 Q9NP79 VTA1 PTHR46009:SF1 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG transport#GO:0006810;vacuolar transport#GO:0007034;intracellular transport#GO:0046907;endosomal transport#GO:0016197;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;cellular process#GO:0009987;late endosome to vacuole transport via multivesicular body sorting pathway#GO:0032511;multivesicular body sorting pathway#GO:0071985;establishment of localization in cell#GO:0051649;late endosome to vacuole transport#GO:0045324;vesicle-mediated transport#GO:0016192;endosome transport via multivesicular body sorting pathway#GO:0032509 cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;intracellular organelle#GO:0043229;late endosome#GO:0005770;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular vesicle#GO:0097708;vesicle#GO:0031982 membrane traffic protein#PC00150 HUMAN|HGNC=7178|UniProtKB=Q13201 Q13201 MMRN1 PTHR15427:SF3 EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER MULTIMERIN-1 binding#GO:0005488;cell adhesion molecule binding#GO:0050839;cell adhesion mediator activity#GO:0098631;protein binding#GO:0005515 regulation of platelet activation#GO:0010543;regulation of platelet aggregation#GO:0090330;cell adhesion#GO:0007155;regulation of cellular process#GO:0050794;regulation of cell-cell adhesion#GO:0022407;regulation of biological process#GO:0050789;regulation of cell activation#GO:0050865;positive regulation of cell adhesion#GO:0045785;cell adhesion mediated by integrin#GO:0033627;regulation of cell adhesion#GO:0030155;biological regulation#GO:0065007;regulation of multicellular organismal process#GO:0051239;positive regulation of cell-cell adhesion#GO:0022409;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987 scaffold/adaptor protein#PC00226 HUMAN|HGNC=6895|UniProtKB=Q9UEW3 Q9UEW3 MARCO PTHR24023:SF1083 COLLAGEN ALPHA MACROPHAGE RECEPTOR MARCO extracellular matrix structural constituent#GO:0005201;structural molecule activity#GO:0005198 extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;external encapsulating structure organization#GO:0045229;cellular component organization#GO:0016043;extracellular structure organization#GO:0043062;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;basement membrane#GO:0005604;extracellular region#GO:0005576 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HUMAN|HGNC=14468|UniProtKB=Q96RN1 Q96RN1 SLC26A8 PTHR11814:SF11 SULFATE TRANSPORTER TESTIS ANION TRANSPORTER 1 chloride transmembrane transporter activity#GO:0015108;bicarbonate transmembrane transporter activity#GO:0015106;antiporter activity#GO:0015297;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic anion transmembrane transporter activity#GO:0008509;secondary active transmembrane transporter activity#GO:0015291;monoatomic ion transmembrane transporter activity#GO:0015075;dicarboxylic acid transmembrane transporter activity#GO:0005310;active transmembrane transporter activity#GO:0022804;carboxylic acid transmembrane transporter activity#GO:0046943 establishment of localization#GO:0051234;transmembrane transport#GO:0055085;chloride transmembrane transport#GO:1902476;localization#GO:0051179;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698;chloride transport#GO:0006821;transport#GO:0006810;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220;monoatomic anion transport#GO:0006820;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227 HUMAN|HGNC=20292|UniProtKB=Q9Y376 Q9Y376 CAB39 PTHR10182:SF11 CALCIUM-BINDING PROTEIN 39-RELATED CALCIUM-BINDING PROTEIN 39 molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;kinase activator activity#GO:0019209;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;protein kinase regulator activity#GO:0019887;protein kinase activator activity#GO:0030295;enzyme activator activity#GO:0008047;protein serine/threonine kinase activator activity#GO:0043539 HUMAN|HGNC=21406|UniProtKB=Q5T160 Q5T160 RARS2 PTHR11956:SF11 ARGINYL-TRNA SYNTHETASE ARGININE--TRNA LIGASE, MITOCHONDRIAL-RELATED catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;ligase activity#GO:0016874 translation#GO:0006412;metabolic process#GO:0008152;mitochondrial gene expression#GO:0140053;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;mitochondrial translation#GO:0032543;protein biosynthetic process#GO:0160307;gene expression#GO:0010467 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 aminoacyl-tRNA synthetase#PC00047 HUMAN|HGNC=7711|UniProtKB=O43181 O43181 NDUFS4 PTHR12219:SF28 NADH-UBIQUINONE OXIDOREDUCTASE NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 4, MITOCHONDRIAL cellular component assembly#GO:0022607;mitochondrion organization#GO:0007005;mitochondrial respiratory chain complex assembly#GO:0033108;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;electron transport chain#GO:0022900;cellular process#GO:0009987;respiratory electron transport chain#GO:0022904;cellular component organization or biogenesis#GO:0071840;energy derivation by oxidation of organic compounds#GO:0015980;protein-containing complex organization#GO:0043933;NADH dehydrogenase complex assembly#GO:0010257;metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091;mitochondrial respiratory chain complex I assembly#GO:0032981;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;cellular respiration#GO:0045333 transmembrane transporter complex#GO:1902495;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;mitochondrion#GO:0005739;transporter complex#GO:1990351;respiratory chain complex I#GO:0045271;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;membrane#GO:0016020;oxidoreductase complex#GO:1990204;respiratory chain complex#GO:0098803 oxidoreductase#PC00176 HUMAN|HGNC=12008|UniProtKB=P17752 P17752 TPH1 PTHR11473:SF23 AROMATIC AMINO ACID HYDROXYLASE TRYPTOPHAN 5-HYDROXYLASE 1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824;monooxygenase activity#GO:0004497;oxidoreductase activity#GO:0016491 serotonin biosynthetic process#GO:0042427;biosynthetic process#GO:0009058;phenol-containing compound biosynthetic process#GO:0046189;phenol-containing compound metabolic process#GO:0018958;cellular process#GO:0009987;indole-containing compound metabolic process#GO:0042430;serotonin metabolic process#GO:0042428;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;neuron projection#GO:0043005 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 5-Hydroxytryptamine biosynthesis#P04371>Tryptophan hydroxylase#P04399 HUMAN|HGNC=24766|UniProtKB=Q6ZVE7 Q6ZVE7 GOLT1A PTHR21493:SF245 CGI-141-RELATED/LIPASE CONTAINING PROTEIN VESICLE TRANSPORT PROTEIN GOT1A membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;membrane#GO:0016020 hydrolase#PC00121;lipase#PC00143;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=12179|UniProtKB=A0A0K0K1G6 A0A0K0K1G6 TRBV10-3 PTHR23268:SF115 T-CELL RECEPTOR BETA CHAIN T CELL RECEPTOR BETA VARIABLE 10-3 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=24299|UniProtKB=Q5SWX8 Q5SWX8 ODR4 PTHR33966:SF1 PROTEIN ODR-4 HOMOLOG PROTEIN ODR-4 HOMOLOG intracellular protein localization#GO:0008104;localization#GO:0051179;macromolecule localization#GO:0033036 HUMAN|HGNC=33872|UniProtKB=Q6UXD1 Q6UXD1 HRCT1 PTHR23009:SF2 FAMILY NOT NAMED HISTIDINE-RICH CARBOXYL TERMINUS PROTEIN 1 HUMAN|HGNC=1286|UniProtKB=Q9NYP9 Q9NYP9 MIS18A PTHR16431:SF2 NEUROGENIC PROTEIN MASTERMIND PROTEIN MIS18-ALPHA chromatin organization#GO:0006325;cellular component assembly#GO:0022607;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;chromosome organization#GO:0051276;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;kinetochore organization#GO:0051383;kinetochore assembly#GO:0051382;organelle assembly#GO:0070925 nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;chromosome, centromeric region#GO:0000775;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228 HUMAN|HGNC=26063|UniProtKB=Q9NWU1 Q9NWU1 OXSM PTHR11712:SF362 POLYKETIDE SYNTHASE-RELATED 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746 monocarboxylic acid biosynthetic process#GO:0072330;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;fatty acid metabolic process#GO:0006631;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;small molecule metabolic process#GO:0044281;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058;fatty acid biosynthetic process#GO:0006633;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;cellular process#GO:0009987;carboxylic acid biosynthetic process#GO:0046394 HUMAN|HGNC=25310|UniProtKB=Q96NW4 Q96NW4 ANKRD27 PTHR24170:SF2 ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 27 ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 27 guanyl-nucleotide exchange factor activity#GO:0005085;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 cell development#GO:0048468;endocytic recycling#GO:0032456;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell morphogenesis#GO:0000902;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;neuron development#GO:0048666;cellular localization#GO:0051641;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;nervous system development#GO:0007399;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;neuron projection development#GO:0031175;cell projection morphogenesis#GO:0048858;endosomal transport#GO:0016197;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;system development#GO:0048731;localization#GO:0051179;anatomical structure development#GO:0048856;localization within membrane#GO:0051668;plasma membrane bounded cell projection organization#GO:0120036;multicellular organismal process#GO:0032501;early endosome to late endosome transport#GO:0045022;vesicle-mediated transport to the plasma membrane#GO:0098876;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;establishment of localization#GO:0051234;developmental process#GO:0032502;transport#GO:0006810;neuron projection morphogenesis#GO:0048812;intracellular transport#GO:0046907 neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;transport vesicle#GO:0030133;endomembrane system#GO:0012505;late endosome#GO:0005770;vesicle#GO:0031982;intracellular vesicle#GO:0097708;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;early endosome#GO:0005769;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=10492|UniProtKB=P29034 P29034 S100A2 PTHR11639:SF59 S100 CALCIUM-BINDING PROTEIN PROTEIN S100-A2 cation binding#GO:0043169;metal ion binding#GO:0046872;protein binding#GO:0005515;calcium ion binding#GO:0005509;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167 cell motility#GO:0048870;endothelial cell migration#GO:0043542;cell migration#GO:0016477;cellular process#GO:0009987 calcium-binding protein#PC00060;calmodulin-related#PC00061 HUMAN|HGNC=28883|UniProtKB=Q9H2U2 Q9H2U2 PPA2 PTHR10286:SF49 INORGANIC PYROPHOSPHATASE INORGANIC PYROPHOSPHATASE 2, MITOCHONDRIAL pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787 metabolic process#GO:0008152;phosphate-containing compound metabolic process#GO:0006796;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 pyrophosphatase#PC00196 HUMAN|HGNC=30078|UniProtKB=Q96HR9 Q96HR9 REEP6 PTHR12300:SF133 HVA22-LIKE PROTEINS RECEPTOR EXPRESSION-ENHANCING PROTEIN 6 membrane traffic protein#PC00150 HUMAN|HGNC=6545|UniProtKB=Q8WTW3 Q8WTW3 COG1 PTHR31658:SF0 CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1 CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 HUMAN|HGNC=24926|UniProtKB=Q15834 Q15834 CCDC85B PTHR13546:SF12 RE60986P COILED-COIL DOMAIN-CONTAINING PROTEIN 85B negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of metabolic process#GO:0009892;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=11085|UniProtKB=O75093 O75093 SLIT1 PTHR45836:SF3 SLIT HOMOLOG SLIT HOMOLOG 1 PROTEIN protein binding#GO:0005515;heparin binding#GO:0008201;signaling receptor binding#GO:0005102;binding#GO:0005488;glycosaminoglycan binding#GO:0005539;carbohydrate derivative binding#GO:0097367 anatomical structure development#GO:0048856;system development#GO:0048731;chemotaxis#GO:0006935;locomotion#GO:0040011;cellular developmental process#GO:0048869;response to external stimulus#GO:0009605;neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;axon development#GO:0061564;axon guidance#GO:0007411;axonogenesis#GO:0007409;neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;cell differentiation#GO:0030154;response to stimulus#GO:0050896;cell projection organization#GO:0030030;cell morphogenesis#GO:0000902;cell development#GO:0048468;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cell projection morphogenesis#GO:0048858;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;response to chemical#GO:0042221;taxis#GO:0042330;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;neuron projection development#GO:0031175;cellular process#GO:0009987 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 Axon guidance mediated by Slit/Robo#P00008>Slit#P00342 HUMAN|HGNC=12749|UniProtKB=Q9GZY6 Q9GZY6 LAT2 PTHR15646:SF5 LINKER FOR ACTIVATION OF T-CELLS FAMILY MEMBER 2 LINKER FOR ACTIVATION OF T-CELLS FAMILY MEMBER 2 immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;positive regulation of response to stimulus#GO:0048584;calcium-mediated signaling#GO:0019722;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;immune response-activating cell surface receptor signaling pathway#GO:0002429;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;leukocyte activation#GO:0045321;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;cell activation#GO:0001775;regulation of immune response#GO:0050776;intracellular signaling cassette#GO:0141124;lymphocyte activation#GO:0046649;antigen receptor-mediated signaling pathway#GO:0050851;B cell receptor signaling pathway#GO:0050853;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;signal transduction#GO:0007165;positive regulation of immune system process#GO:0002684;B cell activation#GO:0042113;immune response-activating signaling pathway#GO:0002757;cell surface receptor signaling pathway#GO:0007166;signaling#GO:0023052;response to stimulus#GO:0050896;immune response-regulating signaling pathway#GO:0002764;regulation of biological process#GO:0050789;immune system process#GO:0002376 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HUMAN|HGNC=12578|UniProtKB=O75841 O75841 UPK1B PTHR47110:SF2 TESTIS-SPECIFIC EXPRESSED PROTEIN 55 UROPLAKIN-1B plasma membrane#GO:0005886;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;apical part of cell#GO:0045177;cell periphery#GO:0071944;apical plasma membrane#GO:0016324;membrane#GO:0016020 HUMAN|HGNC=9393|UniProtKB=P17252 P17252 PRKCA PTHR24356:SF193 SERINE/THREONINE-PROTEIN KINASE PROTEIN KINASE C ALPHA TYPE protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 non-receptor serine/threonine protein kinase#PC00167 Apoptosis signaling pathway#P00006>PKCs#P00318;Alpha adrenergic receptor signaling pathway#P00002>PKC#P00075;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>PKC#P01074;Gonadotropin-releasing hormone receptor pathway#P06664>PKCs#P06733;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>PKC#P00745;CCKR signaling map#P06959>PKCalpha#P07095;Angiotensin II-stimulated signaling through G proteins and beta-arrestin#P05911>PKC#P05942;PDGF signaling pathway#P00047>PKC#P01150;Alzheimer disease-amyloid secretase pathway#P00003>PKC#P00109;Gonadotropin-releasing hormone receptor pathway#P06664>PKCs(3)#P06850;5HT2 type receptor mediated signaling pathway#P04374>PKC#P04420;Angiogenesis#P00005>PKC#P00219;VEGF signaling pathway#P00056>PKC#P01425;Histamine H1 receptor mediated signaling pathway#P04385>PKC#P04487;EGF receptor signaling pathway#P00018>PKC#P00565;Oxytocin receptor mediated signaling pathway#P04391>PKC#P04533;Wnt signaling pathway#P00057>Protein Kinase C#P01458;Thyrotropin-releasing hormone receptor signaling pathway#P04394>PKC#P04583;FGF signaling pathway#P00021>PKC#P00648;Endothelin signaling pathway#P00019>PKC#P00568 HUMAN|HGNC=19071|UniProtKB=Q86V81 Q86V81 ALYREF PTHR19965:SF35 RNA AND EXPORT FACTOR BINDING PROTEIN THO COMPLEX SUBUNIT 4 binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723 localization#GO:0051179;cellular localization#GO:0051641;mRNA export from nucleus#GO:0006406;nucleic acid transport#GO:0050657;nuclear transport#GO:0051169;nuclear export#GO:0051168;nucleocytoplasmic transport#GO:0006913;nucleobase-containing compound transport#GO:0015931;RNA localization#GO:0006403;RNA transport#GO:0050658;establishment of RNA localization#GO:0051236;mRNA transport#GO:0051028;macromolecule metabolic process#GO:0043170;establishment of localization#GO:0051234;metabolic process#GO:0008152;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;transport#GO:0006810;gene expression#GO:0010467;biosynthetic process#GO:0009058;macromolecule localization#GO:0033036;nitrogen compound transport#GO:0071705;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031 HUMAN|HGNC=5397|UniProtKB=P40305 P40305 IFI27 PTHR16932:SF2 INTERFERON ALPHA-INDUCIBLE PROTEIN 27 INTERFERON ALPHA-INDUCIBLE PROTEIN 27, MITOCHONDRIAL intracellular signal transduction#GO:0035556;cell communication#GO:0007154;apoptotic signaling pathway#GO:0097190;intrinsic apoptotic signaling pathway#GO:0097193;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell death#GO:0008219;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;apoptotic process#GO:0006915;programmed cell death#GO:0012501 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;mitochondrial envelope#GO:0005740;organelle envelope#GO:0031967;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=18925|UniProtKB=Q3SY46 Q3SY46 KRTAP13-3 PTHR19051:SF35 KERATIN-ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 13-3 structural protein#PC00211 HUMAN|HGNC=31270|UniProtKB=A6NMZ5 A6NMZ5 OR4C45 PTHR48002:SF75 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 4C45 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=26834|UniProtKB=Q8NCX0 Q8NCX0 CCDC150 PTHR35352:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 150 COILED-COIL DOMAIN-CONTAINING PROTEIN 150 HUMAN|HGNC=21715|UniProtKB=Q7Z442 Q7Z442 PKD1L2 PTHR10877:SF134 POLYCYSTIN FAMILY MEMBER POLYCYSTIN-1-LIKE PROTEIN 2 channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;passive transmembrane transporter activity#GO:0022803;metal ion transmembrane transporter activity#GO:0046873;monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216 response to mechanical stimulus#GO:0009612;response to abiotic stimulus#GO:0009628;detection of mechanical stimulus#GO:0050982;detection of stimulus#GO:0051606;response to external stimulus#GO:0009605;response to stimulus#GO:0050896 membrane#GO:0016020;cellular anatomical structure#GO:0110165 ion channel#PC00133 HUMAN|HGNC=27578|UniProtKB=P0C7P0 P0C7P0 CISD3 PTHR46491:SF3 CDGSH IRON SULFUR DOMAIN PROTEIN HOMOLOG CDGSH IRON-SULFUR DOMAIN-CONTAINING PROTEIN 3, MITOCHONDRIAL iron-sulfur cluster binding#GO:0051536;small molecule binding#GO:0036094;binding#GO:0005488 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 HUMAN|HGNC=25820|UniProtKB=Q9C0D3 Q9C0D3 ZYG11B PTHR12904:SF21 FAMILY NOT NAMED PROTEIN ZYG-11 HOMOLOG B Cul2-RING ubiquitin ligase complex#GO:0031462;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151 HUMAN|HGNC=1170|UniProtKB=Q9NQ31 Q9NQ31 AKIP1 PTHR14330:SF2 A-KINASE-INTERACTING PROTEIN 1 A-KINASE-INTERACTING PROTEIN 1 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974 HUMAN|HGNC=7573|UniProtKB=P11055 P11055 MYH3 PTHR45615:SF6 MYOSIN HEAVY CHAIN, NON-MUSCLE MYOSIN-3 isomerase activity#GO:0016853;cytoskeletal motor activity#GO:0003774;cytoskeletal protein binding#GO:0008092;macromolecular conformation isomerase activity#GO:0120543;microfilament motor activity#GO:0000146;catalytic activity#GO:0003824;protein-containing complex binding#GO:0044877;protein binding#GO:0005515;actin binding#GO:0003779;actin filament binding#GO:0051015;ATP-dependent activity#GO:0140657;polypeptide conformation or assembly isomerase activity#GO:0120544;binding#GO:0005488 muscle system process#GO:0003012;muscle contraction#GO:0006936;system process#GO:0003008;multicellular organismal process#GO:0032501 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;actin cytoskeleton#GO:0015629;myosin complex#GO:0016459;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 actin or actin-binding cytoskeletal protein#PC00041 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Myosin#P00867;Wnt signaling pathway#P00057>NFAT Target Genes#G01559;Cytoskeletal regulation by Rho GTPase#P00016>Myosin#P00522 HUMAN|HGNC=1933|UniProtKB=Q15782 Q15782 CHI3L2 PTHR11177:SF82 CHITINASE CHITINASE-3-LIKE PROTEIN 2 hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787;chitinase activity#GO:0004568;catalytic activity#GO:0003824;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553 chitin metabolic process#GO:0006030;macromolecule catabolic process#GO:0009057;aminoglycan metabolic process#GO:0006022;metabolic process#GO:0008152;aminoglycan catabolic process#GO:0006026;chitin catabolic process#GO:0006032;amino sugar catabolic process#GO:0046348;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;carbohydrate derivative catabolic process#GO:1901136;amino sugar metabolic process#GO:0006040;catabolic process#GO:0009056 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 glycosidase#PC00110;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=17040|UniProtKB=O15234 O15234 CASC3 PTHR13434:SF0 PROTEIN CASC3 PROTEIN CASC3 RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;exon-exon junction complex#GO:0035145;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=689|UniProtKB=Q9Y4X5 Q9Y4X5 ARIH1 PTHR11685:SF475 RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING E3 UBIQUITIN-PROTEIN LIGASE ARIH1 catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein binding#GO:0005515;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;binding#GO:0005488;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;enzyme binding#GO:0019899;ubiquitin-like protein transferase activity#GO:0019787 cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;catabolic process#GO:0009056;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex#GO:1990234;ubiquitin ligase complex#GO:0000151;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=19241|UniProtKB=Q96K78 Q96K78 ADGRG7 PTHR12011:SF305 ADHESION G-PROTEIN COUPLED RECEPTOR ADHESION G PROTEIN-COUPLED RECEPTOR G7 transmembrane signaling receptor activity#GO:0004888;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=22943|UniProtKB=Q96MN2 Q96MN2 NLRP4 PTHR45690:SF6 NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12 NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 4 biological regulation#GO:0065007;regulation of response to external stimulus#GO:0032101;regulation of defense response#GO:0031347;regulation of inflammatory response#GO:0050727;regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;regulation of response to stress#GO:0080134 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090 HUMAN|HGNC=11537|UniProtKB=O00268 O00268 TAF4 PTHR15138:SF18 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4 DNA binding#GO:0003677;nucleic acid binding#GO:0003676;binding#GO:0005488 transcription initiation at RNA polymerase II promoter#GO:0006367;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;transcription by RNA polymerase II#GO:0006366;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;DNA-templated transcription initiation#GO:0006352;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070 RNA polymerase II, holoenzyme#GO:0016591;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;transcription regulator complex#GO:0005667;transferase complex#GO:1990234;protein-containing complex#GO:0032991;transcription factor TFIID complex#GO:0005669;membrane-enclosed lumen#GO:0031974;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;RNA polymerase complex#GO:0030880 general transcription factor#PC00259 General transcription regulation#P00023>TBP-associated factors#P00658;Huntington disease#P00029>TAFII130#P00806;Transcription regulation by bZIP transcription factor#P00055>TBP-associated factors#P01385 HUMAN|HGNC=51509|UniProtKB=A0A494C0Z2 A0A494C0Z2 SPDYE13 PTHR31156:SF15 WBSCR19-LIKE PROTEIN SPEEDY PROTEIN E10-RELATED HUMAN|HGNC=25592|UniProtKB=Q9NV88 Q9NV88 INTS9 PTHR46094:SF1 INTEGRATOR COMPLEX SUBUNIT 9 INTEGRATOR COMPLEX SUBUNIT 9 biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;snRNA processing#GO:0016180;RNA 3'-end processing#GO:0031123;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;snRNA 3'-end processing#GO:0034472;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;snRNA metabolic process#GO:0016073;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;integrator complex#GO:0032039;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513 HUMAN|HGNC=11402|UniProtKB=Q9UPE1 Q9UPE1 SRPK3 PTHR47634:SF20 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED SRSF PROTEIN KINASE 3 protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;RNA biosynthetic process#GO:0032774;RNA splicing, via transesterification reactions#GO:0000375;cell communication#GO:0007154;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;protein-RNA complex assembly#GO:0022618;intracellular signal transduction#GO:0035556;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;macromolecule biosynthetic process#GO:0009059;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of mRNA processing#GO:0050684;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;macromolecule metabolic process#GO:0043170;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;regulation of biological process#GO:0050789;mRNA splicing, via spliceosome#GO:0000398;response to stimulus#GO:0050896;mRNA metabolic process#GO:0016071;signaling#GO:0023052;ribonucleoprotein complex biogenesis#GO:0022613;nucleic acid biosynthetic process#GO:0141187;spliceosomal complex assembly#GO:0000245;RNA metabolic process#GO:0016070;cellular component biogenesis#GO:0044085;mRNA processing#GO:0006397;signal transduction#GO:0007165;cellular process#GO:0009987;cellular component assembly#GO:0022607;gene expression#GO:0010467;RNA processing#GO:0006396;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;cellular component organization or biogenesis#GO:0071840;regulation of mRNA metabolic process#GO:1903311;protein-RNA complex organization#GO:0071826;protein-containing complex organization#GO:0043933 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=13328|UniProtKB=Q13325 Q13325 IFIT5 PTHR10271:SF28 INTERFERON-INDUCED PROTEIN WITH TETRATRICOPEPTIDE REPEATS INTERFERON-INDUCED PROTEIN WITH TETRATRICOPEPTIDE REPEATS 5 binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 response to stress#GO:0006950;response to biotic stimulus#GO:0009607;immune response#GO:0006955;defense response to symbiont#GO:0140546;defense response to other organism#GO:0098542;response to cytokine#GO:0034097;response to chemical#GO:0042221;response to other organism#GO:0051707;innate immune response#GO:0045087;defense response#GO:0006952;response to external stimulus#GO:0009605;defense response to virus#GO:0051607;antiviral innate immune response#GO:0140374;cellular response to cytokine stimulus#GO:0071345;response to stimulus#GO:0050896;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;immune system process#GO:0002376;response to virus#GO:0009615;response to peptide#GO:1901652 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 defense/immunity protein#PC00090 HUMAN|HGNC=166|UniProtKB=O43707 O43707 ACTN4 PTHR11915:SF425 SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN ALPHA-ACTININ-4 binding#GO:0005488;actin binding#GO:0003779;actin filament binding#GO:0051015;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877 cytoskeleton organization#GO:0007010;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;developmental process#GO:0032502;cell development#GO:0048468;cell differentiation#GO:0030154;actin cytoskeleton organization#GO:0030036;muscle structure development#GO:0061061;muscle cell differentiation#GO:0042692;muscle cell development#GO:0055001;cellular component organization#GO:0016043;anatomical structure development#GO:0048856;actin filament-based process#GO:0030029;animal gross anatomical part developmental process#GO:0160108 intracellular organelle#GO:0043229;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;myofibril#GO:0030016;cell cortex#GO:0005938;actin cytoskeleton#GO:0015629;cortical cytoskeleton#GO:0030863;cell projection#GO:0042995;organelle#GO:0043226;cellular anatomical structure#GO:0110165;I band#GO:0031674;cytoskeleton#GO:0005856;cell junction#GO:0030054;sarcomere#GO:0030017;membraneless organelle#GO:0043228;contractile muscle fiber#GO:0043292;Z disc#GO:0030018;cell periphery#GO:0071944;membrane#GO:0016020;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;cytoplasm#GO:0005737;cortical actin cytoskeleton#GO:0030864;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081 actin or actin-binding cytoskeletal protein#PC00041 Integrin signalling pathway#P00034>alpha actinin#P00928 HUMAN|HGNC=17036|UniProtKB=O75711 O75711 SCRG1 PTHR17463:SF0 SCRAPIE-RESPONSIVE PROTEIN 1 SCRG1 SCRAPIE-RESPONSIVE PROTEIN 1 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;neuron projection terminus#GO:0044306;cell projection#GO:0042995;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;neuron projection#GO:0043005 HUMAN|HGNC=4593|UniProtKB=Q13255 Q13255 GRM1 PTHR24060:SF29 METABOTROPIC GLUTAMATE RECEPTOR METABOTROPIC GLUTAMATE RECEPTOR 1 adenylate cyclase inhibiting G protein-coupled glutamate receptor activity#GO:0001640;glutamate receptor activity#GO:0008066;transmembrane signaling receptor activity#GO:0004888;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;modulation of chemical synaptic transmission#GO:0050804;signaling#GO:0023052;regulation of cell communication#GO:0010646;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;regulation of synaptic transmission, glutamatergic#GO:0051966;cell communication#GO:0007154;glutamate receptor signaling pathway#GO:0007215;G protein-coupled receptor signaling pathway#GO:0007186;regulation of signaling#GO:0023051;regulation of trans-synaptic signaling#GO:0099177;biological regulation#GO:0065007;signal transduction#GO:0007165;cellular process#GO:0009987;cell surface receptor signaling pathway#GO:0007166 membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane region#GO:0098590;postsynaptic specialization#GO:0099572;neuron to neuron synapse#GO:0098984;plasma membrane#GO:0005886;synaptic membrane#GO:0097060;cell junction#GO:0030054;postsynapse#GO:0098794;organelle#GO:0043226;asymmetric synapse#GO:0032279;synapse#GO:0045202;cellular anatomical structure#GO:0110165;postsynaptic specialization membrane#GO:0099634;postsynaptic membrane#GO:0045211;postsynaptic density#GO:0014069;postsynaptic density membrane#GO:0098839 G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;Metabotropic glutamate receptor group III pathway#P00039>mGluR 1/5#P01040;Endogenous cannabinoid signaling#P05730>mGluR#P05748;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GqPCR#P00730;Metabotropic glutamate receptor group I pathway#P00041>mGluR1#P01062;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GoPCR#P00725;Metabotropic glutamate receptor group I pathway#P00041>mGluR5#P01061 HUMAN|HGNC=1552|UniProtKB=Q14781 Q14781 CBX2 PTHR46860:SF1 CHROMOBOX PROTEIN HOMOLOG 2 CHROMOBOX PROTEIN HOMOLOG 2 histone reader activity#GO:0140566;histone H3K9me2/3 reader activity#GO:0062072;histone H3 reader activity#GO:0140006;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;chromatin-protein adaptor activity#GO:0140463 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519 chromatin#GO:0000785;nucleus#GO:0005634;PcG protein complex#GO:0031519;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;transferase complex#GO:1990234;PRC1 complex#GO:0035102;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;heterochromatin#GO:0000792;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;nuclear ubiquitin ligase complex#GO:0000152;organelle#GO:0043226;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ubiquitin ligase complex#GO:0000151 HUMAN|HGNC=22146|UniProtKB=Q2M3M2 Q2M3M2 SLC5A9 PTHR11819:SF96 SOLUTE CARRIER FAMILY 5 SODIUM_GLUCOSE COTRANSPORTER 4 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227;secondary carrier transporter#PC00258 HUMAN|HGNC=408|UniProtKB=P51649 P51649 ALDH5A1 PTHR43353:SF14 SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL aldehyde dehydrogenase (NAD+) activity#GO:0004029;oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor#GO:0016620;oxidoreductase activity, acting on the aldehyde or oxo group of donors#GO:0016903;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;amino acid metabolic process#GO:0006520;small molecule catabolic process#GO:0044282;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 metabolite interconversion enzyme#PC00262;dehydrogenase#PC00092;oxidoreductase#PC00176 Gamma-aminobutyric acid synthesis#P04384>Succinic semialdehyde dehydrogenase#P04481;Aminobutyrate degradation#P02726>Succinate semi-aldehyde dehydrogenase#P02824 HUMAN|HGNC=20628|UniProtKB=Q9UI26 Q9UI26 IPO11 PTHR10997:SF7 IMPORTIN-7, 8, 11 IMPORTIN-11 nucleocytoplasmic carrier activity#GO:0140142;molecular carrier activity#GO:0140104 protein localization to nucleus#GO:0034504;import into nucleus#GO:0051170;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;intracellular protein localization#GO:0008104;protein localization to organelle#GO:0033365;nucleocytoplasmic transport#GO:0006913;cellular localization#GO:0051641;localization#GO:0051179;protein import into nucleus#GO:0006606;protein transport#GO:0015031;nuclear transport#GO:0051169 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cytosol#GO:0005829;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nuclear envelope#GO:0005635;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226 transporter#PC00227 HUMAN|HGNC=2520|UniProtKB=Q9NRF8 Q9NRF8 CTPS2 PTHR11550:SF2 CTP SYNTHASE CTP SYNTHASE 2 protein binding#GO:0005515;ligase activity, forming carbon-nitrogen bonds#GO:0016879;identical protein binding#GO:0042802;catalytic activity#GO:0003824;binding#GO:0005488;ligase activity#GO:0016874 ribonucleotide metabolic process#GO:0009259;organophosphate biosynthetic process#GO:0090407;nucleotide metabolic process#GO:0009117;nucleotide biosynthetic process#GO:0009165;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;nucleoside triphosphate metabolic process#GO:0009141;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;pyrimidine nucleobase metabolic process#GO:0006206;carbohydrate derivative biosynthetic process#GO:1901137;ribonucleoside triphosphate biosynthetic process#GO:0009201;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase metabolic process#GO:0009112;nucleobase-containing small molecule metabolic process#GO:0055086;nucleoside triphosphate biosynthetic process#GO:0009142;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;pyrimidine-containing compound metabolic process#GO:0072527;ribose phosphate metabolic process#GO:0019693;carbohydrate derivative metabolic process#GO:1901135;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058 supramolecular fiber#GO:0099512;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;supramolecular complex#GO:0099080;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081 metabolite interconversion enzyme#PC00262;ligase#PC00142 De novo pyrimidine ribonucleotides biosythesis#P02740>CTP synthase#P02931 HUMAN|HGNC=25162|UniProtKB=Q96EH8 Q96EH8 NEURL3 PTHR12429:SF9 NEURALIZED E3 UBIQUITIN-PROTEIN LIGASE NEURL3 ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740 regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;endocytosis#GO:0006897;protein localization to organelle#GO:0033365;regulation of biological process#GO:0050789;protein transport#GO:0015031;localization#GO:0051179;regulation of signaling#GO:0023051;regulation of Notch signaling pathway#GO:0008593;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;establishment of protein localization#GO:0045184;macromolecule localization#GO:0033036;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;import into cell#GO:0098657;establishment of protein localization to organelle#GO:0072594;transport#GO:0006810;regulation of response to stimulus#GO:0048583 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;early endosome#GO:0005769;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=9064|UniProtKB=Q9UPR0 Q9UPR0 PLCL2 PTHR10336:SF84 PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN INACTIVE PHOSPHOLIPASE C-LIKE PROTEIN 2 lipase activity#GO:0016298;hydrolase activity#GO:0016787;glycerophospholipase activity#GO:0004620;catalytic activity#GO:0003824;phospholipase activity#GO:0120569;hydrolase activity, acting on ester bonds#GO:0016788;phosphoric ester hydrolase activity#GO:0042578;phosphoric diester hydrolase activity#GO:0008081 cellular process#GO:0009987;regulation of biological process#GO:0050789;regulation of cell communication#GO:0010646;modulation of chemical synaptic transmission#GO:0050804;cell-cell signaling#GO:0007267;signaling#GO:0023052;biological regulation#GO:0065007;regulation of trans-synaptic signaling#GO:0099177;regulation of cellular process#GO:0050794;regulation of signaling#GO:0023051;cell communication#GO:0007154 hydrolase#PC00121;lipase#PC00143;phospholipase#PC00186;metabolite interconversion enzyme#PC00262 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PLCbetagamma#P00874;Thyrotropin-releasing hormone receptor signaling pathway#P04394>PLC#P04581;Oxytocin receptor mediated signaling pathway#P04391>PLC beta#P04530;Histamine H1 receptor mediated signaling pathway#P04385>PLC#P04484;5HT2 type receptor mediated signaling pathway#P04374>PLC#P04412 HUMAN|HGNC=11245|UniProtKB=P20155 P20155 SPINK2 PTHR47608:SF1 SERINE PROTEASE INHIBITOR KAZAL-TYPE 2, SPINK2 SERINE PROTEASE INHIBITOR KAZAL-TYPE 2 reproductive process#GO:0022414;cellular process involved in reproduction in multicellular organism#GO:0022412;cell development#GO:0048468;gamete generation#GO:0007276;cell differentiation#GO:0030154;germ cell development#GO:0007281;developmental process involved in reproduction#GO:0003006;multicellular organismal reproductive process#GO:0048609;anatomical structure development#GO:0048856;spermatid development#GO:0007286;sexual reproduction#GO:0019953;spermatid differentiation#GO:0048515;male gamete generation#GO:0048232;cellular process#GO:0009987;cellular developmental process#GO:0048869;spermatogenesis#GO:0007283;developmental process#GO:0032502 acrosomal vesicle#GO:0001669;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;secretory vesicle#GO:0099503;intracellular vesicle#GO:0097708;vesicle#GO:0031982;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 protease inhibitor#PC00191;protein-binding activity modulator#PC00095 HUMAN|HGNC=16473|UniProtKB=Q8N427 Q8N427 NME8 PTHR46135:SF2 NME/NM23 FAMILY MEMBER 8 PROTEIN NME8 protein binding#GO:0005515;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;microtubule binding#GO:0008017 sperm motility#GO:0097722;cellular component organization#GO:0016043;cilium assembly#GO:0060271;reproductive process#GO:0022414;microtubule-based movement#GO:0007018;cell motility#GO:0048870;cell projection organization#GO:0030030;cilium or flagellum-dependent cell motility#GO:0001539;cilium movement#GO:0003341;organelle assembly#GO:0070925;cilium organization#GO:0044782;cilium-dependent cell motility#GO:0060285;cellular process#GO:0009987;cell projection assembly#GO:0030031;cilium movement involved in cell motility#GO:0060294;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;plasma membrane bounded cell projection assembly#GO:0120031;flagellated sperm motility#GO:0030317;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840 intracellular organelle#GO:0043229;9+2 motile cilium#GO:0097729;cilium#GO:0005929;axoneme#GO:0005930;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;sperm principal piece#GO:0097228;cellular anatomical structure#GO:0110165;motile cilium#GO:0031514;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;sperm flagellum#GO:0036126;ciliary plasm#GO:0097014;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232 HUMAN|HGNC=28334|UniProtKB=Q96BW1 Q96BW1 UPRT PTHR10285:SF171 URIDINE KINASE URACIL PHOSPHORIBOSYLTRANSFERASE HOMOLOG cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 kinase#PC00137;nucleotide kinase#PC00172 Salvage pyrimidine ribonucleotides#P02775>Uracil phosphoribosyl transferase#P03151 HUMAN|HGNC=14454|UniProtKB=Q9UN88 Q9UN88 GABRQ PTHR18945:SF579 NEUROTRANSMITTER GATED ION CHANNEL GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT THETA gated channel activity#GO:0022836;transmembrane signaling receptor activity#GO:0004888;transporter activity#GO:0005215;monoatomic anion transmembrane transporter activity#GO:0008509;neurotransmitter receptor activity#GO:0030594;chloride channel activity#GO:0005254;signaling receptor activity#GO:0038023;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;ligand-gated monoatomic ion channel activity#GO:0015276;channel activity#GO:0015267;molecular transducer activity#GO:0060089;monoatomic anion channel activity#GO:0005253;transmembrane transporter activity#GO:0022857;ligand-gated channel activity#GO:0022834;chloride transmembrane transporter activity#GO:0015108;passive transmembrane transporter activity#GO:0022803 regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;monoatomic anion transport#GO:0006820;signaling#GO:0023052;anterograde trans-synaptic signaling#GO:0098916;trans-synaptic signaling#GO:0099537;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698;transmembrane transport#GO:0055085;cell communication#GO:0007154;chloride transmembrane transport#GO:1902476;localization#GO:0051179;cellular process#GO:0009987;synaptic signaling#GO:0099536;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;monoatomic anion transmembrane transport#GO:0098656;transport#GO:0006810;chloride transport#GO:0006821;establishment of localization#GO:0051234 GABA-ergic synapse#GO:0098982;plasma membrane#GO:0005886;synapse#GO:0045202;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020;cell junction#GO:0030054;signaling receptor complex#GO:0043235 ligand-gated ion channel#PC00141 HUMAN|HGNC=2676|UniProtKB=O43293 O43293 DAPK3 PTHR24342:SF18 SERINE/THREONINE-PROTEIN KINASE 17 DEATH-ASSOCIATED PROTEIN KINASE 3 catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 regulation of apoptotic process#GO:0042981;positive regulation of apoptotic process#GO:0043065;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;regulation of programmed cell death#GO:0043067;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;positive regulation of programmed cell death#GO:0043068 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=8048|UniProtKB=P36639 P36639 NUDT1 PTHR43758:SF2 7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE OXIDIZED PURINE NUCLEOSIDE TRIPHOSPHATE HYDROLASE hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;nucleoside triphosphate diphosphatase activity#GO:0047429;hydrolase activity#GO:0016787 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stress#GO:0006950;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;nucleobase-containing compound metabolic process#GO:0006139;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 phosphatase#PC00181;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=55105|UniProtKB=S4R3C0 S4R3C0 IGHV3OR16-17 PTHR23266:SF302 IMMUNOGLOBULIN HEAVY CHAIN IG-LIKE DOMAIN-CONTAINING PROTEIN binding#GO:0005488;antigen binding#GO:0003823 lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;immune system process#GO:0002376;immune effector process#GO:0002252;response to stimulus#GO:0050896;adaptive immune response#GO:0002250;immune response#GO:0006955 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=19017|UniProtKB=Q86XT4 Q86XT4 TRIM50 PTHR24103:SF326 E3 UBIQUITIN-PROTEIN LIGASE TRIM E3 UBIQUITIN-PROTEIN LIGASE TRIM50 ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to other organism#GO:0051707;response to stimulus#GO:0050896;defense response to other organism#GO:0098542;immune response#GO:0006955;defense response to symbiont#GO:0140546;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;response to external stimulus#GO:0009605;defense response#GO:0006952;innate immune response#GO:0045087;immune system process#GO:0002376 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=17105|UniProtKB=Q8N1M1 Q8N1M1 BEST3 PTHR10736:SF2 BESTROPHIN BESTROPHIN-3 monoatomic anion channel activity#GO:0005253;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;chloride channel activity#GO:0005254;passive transmembrane transporter activity#GO:0022803;chloride transmembrane transporter activity#GO:0015108;monoatomic anion transmembrane transporter activity#GO:0008509;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;chloride transmembrane transport#GO:1902476;transport#GO:0006810;chloride transport#GO:0006821;monoatomic ion transmembrane transport#GO:0034220;monoatomic anion transmembrane transport#GO:0098656;cellular process#GO:0009987;monoatomic anion transport#GO:0006820 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=24770|UniProtKB=Q0D2K2 Q0D2K2 KLHL30 PTHR24412:SF398 KELCH PROTEIN KELCH-LIKE PROTEIN 30 ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056 Cul3-RING ubiquitin ligase complex#GO:0031463;ubiquitin ligase complex#GO:0000151;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;transferase complex#GO:1990234;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cullin-RING ubiquitin ligase complex#GO:0031461;cytoplasm#GO:0005737 scaffold/adaptor protein#PC00226 HUMAN|HGNC=7733|UniProtKB=Q14511 Q14511 NEDD9 PTHR10654:SF20 CAS SCAFFOLDING PROTEIN ENHANCER OF FILAMENTATION 1 cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;cell motility#GO:0048870;regulation of cellular process#GO:0050794;cell migration#GO:0016477 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=30646|UniProtKB=Q7KZF4 Q7KZF4 SND1 PTHR12302:SF2 EBNA2 BINDING PROTEIN P100 STAPHYLOCOCCAL NUCLEASE DOMAIN-CONTAINING PROTEIN 1 RNA endonuclease activity#GO:0004521;catalytic activity, acting on RNA#GO:0140098;endonuclease activity#GO:0004519;nuclease activity#GO:0004518;RNA nuclease activity#GO:0004540;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640 RNA metabolic process#GO:0016070;RNA catabolic process#GO:0006401;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;macromolecule catabolic process#GO:0009057;negative regulation of cellular process#GO:0048523;metabolic process#GO:0008152;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;nucleic acid catabolic process#GO:0141188;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;nucleobase-containing compound catabolic process#GO:0034655;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=326|UniProtKB=Q9NRZ7 Q9NRZ7 AGPAT3 PTHR10983:SF9 1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED 1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE GAMMA acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 transferase#PC00220;acyltransferase#PC00042 HUMAN|HGNC=2211|UniProtKB=P12109 P12109 COL6A1 PTHR24020:SF18 COLLAGEN ALPHA COLLAGEN ALPHA-1(VI) CHAIN muscle structure development#GO:0061061;cell differentiation#GO:0030154;cell development#GO:0048468;muscle cell development#GO:0055001;muscle cell differentiation#GO:0042692;anatomical structure development#GO:0048856;striated muscle cell development#GO:0055002;muscle tissue development#GO:0060537;animal gross anatomical part developmental process#GO:0160108;skeletal muscle organ development#GO:0060538;tissue development#GO:0009888;cellular process#GO:0009987;skeletal muscle tissue development#GO:0007519;animal organ development#GO:0048513;cellular developmental process#GO:0048869;striated muscle cell differentiation#GO:0051146;muscle organ development#GO:0007517;striated muscle tissue development#GO:0014706;developmental process#GO:0032502 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012 extracellular matrix structural protein#PC00103 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>EMC#P00863;Integrin signalling pathway#P00034>Collagen#P00922 HUMAN|HGNC=1087|UniProtKB=Q9UMX3 Q9UMX3 BOK PTHR11256:SF48 BCL-2 RELATED BCL-2-RELATED OVARIAN KILLER PROTEIN passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;channel activity#GO:0015267 signaling#GO:0023052;extrinsic apoptotic signaling pathway#GO:0097191;response to stimulus#GO:0050896;release of cytochrome c from mitochondria#GO:0001836;positive regulation of programmed cell death#GO:0043068;regulation of biological process#GO:0050789;apoptotic process#GO:0006915;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;cellular component organization#GO:0016043;intrinsic apoptotic signaling pathway#GO:0097193;cellular response to stress#GO:0033554;mitochondrion organization#GO:0007005;apoptotic mitochondrial changes#GO:0008637;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;negative regulation of programmed cell death#GO:0043069;cellular process#GO:0009987;intrinsic apoptotic signaling pathway in response to DNA damage#GO:0008630;organelle organization#GO:0006996;response to stress#GO:0006950;positive regulation of apoptotic process#GO:0043065;cellular component organization or biogenesis#GO:0071840;regulation of apoptotic process#GO:0042981;cell surface receptor signaling pathway#GO:0007166;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;cell death#GO:0008219;programmed cell death#GO:0012501;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;biological regulation#GO:0065007;negative regulation of apoptotic process#GO:0043066;positive regulation of cellular process#GO:0048522;apoptotic signaling pathway#GO:0097190;DNA damage response#GO:0006974;negative regulation of cellular process#GO:0048523 intracellular organelle#GO:0043229;outer membrane#GO:0019867;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle envelope#GO:0031967;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;mitochondrial outer membrane#GO:0005741;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane#GO:0016020;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;organelle outer membrane#GO:0031968;cytoplasm#GO:0005737 Apoptosis signaling pathway#P00006>Bok#P00261 HUMAN|HGNC=17300|UniProtKB=Q7Z7C8 Q7Z7C8 TAF8 PTHR46469:SF1 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8 RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;DNA-templated transcription initiation#GO:0006352;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;macromolecule metabolic process#GO:0043170;transcription by RNA polymerase II#GO:0006366;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;transcription initiation at RNA polymerase II promoter#GO:0006367 RNA polymerase II, holoenzyme#GO:0016591;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;nuclear protein-containing complex#GO:0140513;transcription regulator complex#GO:0005667;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;protein-containing complex#GO:0032991;transcription factor TFIID complex#GO:0005669;RNA polymerase II transcription regulator complex#GO:0090575;membrane-enclosed lumen#GO:0031974;RNA polymerase complex#GO:0030880;nucleus#GO:0005634 General transcription by RNA polymerase I#P00022>TAF-IB#P00650;General transcription by RNA polymerase I#P00022>TAF-IA#P00651;General transcription by RNA polymerase I#P00022>TAF-IC#P00649;General transcription regulation#P00023>TBP-associated factors#P00658;General transcription by RNA polymerase I#P00022>SL1 complex#P00653;Transcription regulation by bZIP transcription factor#P00055>TBP-associated factors#P01385 HUMAN|HGNC=7809|UniProtKB=P08138 P08138 NGFR PTHR46605:SF3 TUMOR NECROSIS FACTOR RECEPTOR TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 16 growth factor binding#GO:0019838;molecular transducer activity#GO:0060089;protein binding#GO:0005515;transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488;death receptor activity#GO:0005035;signaling receptor activity#GO:0038023;coreceptor activity#GO:0015026 intracellular signal transduction#GO:0035556;Rho protein signal transduction#GO:0007266;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;intracellular signaling cassette#GO:0141124;signaling#GO:0023052;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cell surface#GO:0009986;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=1663|UniProtKB=P16671 P16671 CD36 PTHR11923:SF12 SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1 PLATELET GLYCOPROTEIN 4 protein-containing complex binding#GO:0044877;cargo receptor activity#GO:0038024;low-density lipoprotein particle receptor activity#GO:0005041;low-density lipoprotein particle binding#GO:0030169;protein-lipid complex binding#GO:0071814;lipoprotein particle binding#GO:0071813;binding#GO:0005488 macromolecule localization#GO:0033036;lipid storage#GO:0019915;establishment of protein localization#GO:0045184;cellular process#GO:0009987;lipid transport#GO:0006869;vesicle-mediated transport#GO:0016192;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;metabolic process#GO:0008152;organic acid transport#GO:0015849;carboxylic acid transport#GO:0046942;transport#GO:0006810;import into cell#GO:0098657;plasma lipoprotein particle clearance#GO:0034381;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;receptor-mediated endocytosis#GO:0006898;regulation of biological process#GO:0050789;catabolic process#GO:0009056;endocytosis#GO:0006897;lipid localization#GO:0010876;fatty acid transport#GO:0015908;localization#GO:0051179;protein transport#GO:0015031;monocarboxylic acid transport#GO:0015718 cell periphery#GO:0071944;caveola#GO:0005901;membrane raft#GO:0045121;membrane#GO:0016020;plasma membrane#GO:0005886;plasma membrane region#GO:0098590;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;membrane microdomain#GO:0098857;plasma membrane raft#GO:0044853 membrane trafficking regulatory protein#PC00151;membrane traffic protein#PC00150 HUMAN|HGNC=11320|UniProtKB=Q8IZP0 Q8IZP0 ABI1 PTHR10460:SF2 ABL INTERACTOR FAMILY MEMBER ABL INTERACTOR 1 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;signaling adaptor activity#GO:0035591 cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell morphogenesis#GO:0000902;cell motility#GO:0048870;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;cell migration#GO:0016477;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;cellular process#GO:0009987;multicellular organism development#GO:0007275;neuron migration#GO:0001764;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;cell projection morphogenesis#GO:0048858;neurogenesis#GO:0022008;developmental process#GO:0032502 cell leading edge#GO:0031252;actin cytoskeleton#GO:0015629;actin-based cell projection#GO:0098858;organelle#GO:0043226;lamellipodium#GO:0030027;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HUMAN|HGNC=18673|UniProtKB=Q96JB5 Q96JB5 CDK5RAP3 PTHR14894:SF2 CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 3 CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 3 ubiquitin-like ligase-substrate adaptor activity#GO:1990756;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;enzyme-substrate adaptor activity#GO:0140767 regulation of mitotic cell cycle#GO:0007346;cellular process#GO:0009987;signal transduction#GO:0007165;response to stress#GO:0006950;endoplasmic reticulum unfolded protein response#GO:0030968;biological regulation#GO:0065007;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;response to topologically incorrect protein#GO:0035966;regulation of cell cycle#GO:0051726;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to topologically incorrect protein#GO:0035967;cellular response to stress#GO:0033554;cellular response to unfolded protein#GO:0034620;response to endoplasmic reticulum stress#GO:0034976;intracellular signal transduction#GO:0035556;response to unfolded protein#GO:0006986;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 HUMAN|HGNC=1943|UniProtKB=P15882 P15882 CHN1 PTHR46075:SF1 CHIMERIN FAMILY MEMBER N-CHIMAERIN molecular function regulator activity#GO:0098772;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;neuron projection development#GO:0031175;cellular process#GO:0009987;signal transduction#GO:0007165;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cell projection morphogenesis#GO:0048858;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell surface receptor signaling pathway#GO:0007166;neuron differentiation#GO:0030182;cell morphogenesis#GO:0000902;cell differentiation#GO:0030154;cell projection organization#GO:0030030;response to stimulus#GO:0050896;cell development#GO:0048468;signaling#GO:0023052;cellular component organization#GO:0016043;motor neuron axon guidance#GO:0008045;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;neuron development#GO:0048666;axonogenesis#GO:0007409;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;axon guidance#GO:0007411;axon development#GO:0061564;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;neuron projection guidance#GO:0097485;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;ephrin receptor signaling pathway#GO:0048013;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;cell communication#GO:0007154;system development#GO:0048731;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169 HUMAN|HGNC=39042|UniProtKB=P60509 P60509 ERVPABLB-1 PTHR10424:SF8 VIRAL ENVELOPE PROTEIN ENDOGENOUS RETROVIRUS GROUP PABLB MEMBER 1 ENV POLYPROTEIN muscle structure development#GO:0061061;cell differentiation#GO:0030154;cellular process#GO:0009987;muscle cell differentiation#GO:0042692;myoblast fusion#GO:0007520;striated muscle cell differentiation#GO:0051146;cellular developmental process#GO:0048869;anatomical structure development#GO:0048856;syncytium formation by cell-cell fusion#GO:0000768;developmental process#GO:0032502;animal gross anatomical part developmental process#GO:0160108;cell-cell fusion#GO:0140253 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 viral or transposable element protein#PC00237 HUMAN|HGNC=9934|UniProtKB=Q15293 Q15293 RCN1 PTHR10827:SF17 RETICULOCALBIN RETICULOCALBIN-1 small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;calcium ion binding#GO:0005509;metal ion binding#GO:0046872;cation binding#GO:0043169 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 calmodulin-related#PC00061;calcium-binding protein#PC00060 HUMAN|HGNC=6852|UniProtKB=O43283 O43283 MAP3K13 PTHR44329:SF14 SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 13 protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740 regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cellular response to stress#GO:0033554;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;MAPK cascade#GO:0000165;signal transduction#GO:0007165;cellular process#GO:0009987;response to stress#GO:0006950;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124;JNK cascade#GO:0007254;stress-activated MAPK cascade#GO:0051403 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 Gonadotropin-releasing hormone receptor pathway#P06664>MAP3Ks#P06834 HUMAN|HGNC=4235|UniProtKB=P14136 P14136 GFAP PTHR45652:SF9 GLIAL FIBRILLARY ACIDIC PROTEIN GLIAL FIBRILLARY ACIDIC PROTEIN structural constituent of cytoskeleton#GO:0005200;structural molecule activity#GO:0005198 regulation of protein catabolic process#GO:0042176;supramolecular fiber organization#GO:0097435;intermediate filament-based process#GO:0045103;intermediate filament organization#GO:0045109;regulation of cellular process#GO:0050794;intermediate filament cytoskeleton organization#GO:0045104;regulation of macromolecule metabolic process#GO:0060255;cellular component organization#GO:0016043;regulation of autophagy#GO:0010506;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;regulation of catabolic process#GO:0009894;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;organelle organization#GO:0006996;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987 cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;organelle#GO:0043226;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intermediate filament#GO:0005882;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228 cytoskeletal protein#PC00085;intermediate filament#PC00129 HUMAN|HGNC=28599|UniProtKB=Q8NEF3 Q8NEF3 CCDC112 PTHR21549:SF0 MUTATED IN BLADDER CANCER 1 COILED-COIL DOMAIN-CONTAINING PROTEIN 112 HUMAN|HGNC=2721|UniProtKB=O43150 O43150 ASAP2 PTHR45854:SF4 ASAP FAMILY MEMBER ARF-GAP WITH SH3 DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 2 enzyme activator activity#GO:0008047;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HUMAN|HGNC=30766|UniProtKB=Q9Y228 Q9Y228 TRAF3IP3 PTHR15715:SF21 CENTROSOMAL PROTEIN OF 170 KDA TRAF3-INTERACTING JNK-ACTIVATING MODULATOR molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 positive regulation of response to biotic stimulus#GO:0002833;response to external stimulus#GO:0009605;pattern recognition receptor signaling pathway#GO:0002221;defense response#GO:0006952;regulation of innate immune response#GO:0045088;innate immune response#GO:0045087;positive regulation of defense response#GO:0031349;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;regulation of response to stress#GO:0080134;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;response to other organism#GO:0051707;positive regulation of response to stimulus#GO:0048584;negative regulation of response to stimulus#GO:0048585;immune response#GO:0006955;positive regulation of innate immune response#GO:0045089;activation of innate immune response#GO:0002218;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;response to virus#GO:0009615;regulation of immune response#GO:0050776;regulation of defense response#GO:0031347;response to external biotic stimulus#GO:0043207;intracellular receptor signaling pathway#GO:0030522;regulation of response to biotic stimulus#GO:0002831;regulation of cell communication#GO:0010646;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;antiviral innate immune response#GO:0140374;innate immune response-activating signaling pathway#GO:0002758;immune response-activating signaling pathway#GO:0002757;positive regulation of response to external stimulus#GO:0032103;negative regulation of signal transduction#GO:0009968;regulation of response to external stimulus#GO:0032101;defense response to other organism#GO:0098542;activation of immune response#GO:0002253;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;defense response to symbiont#GO:0140546;cellular process#GO:0009987;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;positive regulation of immune system process#GO:0002684;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of hippo signaling#GO:0035331;cytoplasmic pattern recognition receptor signaling pathway#GO:0002753;regulation of signaling#GO:0023051;immune system process#GO:0002376;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052;regulation of hippo signaling#GO:0035330;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;immune response-regulating signaling pathway#GO:0002764;negative regulation of biological process#GO:0048519;defense response to virus#GO:0051607 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;mitochondrial envelope#GO:0005740;organelle envelope#GO:0031967;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 scaffold/adaptor protein#PC00226 HUMAN|HGNC=19196|UniProtKB=Q8IXZ3 Q8IXZ3 SP8 PTHR23235:SF25 KRUEPPEL-LIKE TRANSCRIPTION FACTOR TRANSCRIPTION FACTOR SP8 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 C2H2 zinc finger transcription factor#PC00248 Huntington disease#P00029>Sp1#P00803 HUMAN|HGNC=26538|UniProtKB=Q5TIE3 Q5TIE3 VWA5B1 PTHR46299:SF1 VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5B2-RELATED VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5B1 HUMAN|HGNC=22963|UniProtKB=O75448 O75448 MED24 PTHR12898:SF1 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 24 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 24 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of biological process#GO:0050789;regulation of DNA-templated transcription initiation#GO:2000142;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 nucleus#GO:0005634;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;mediator complex#GO:0016592;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 RNA metabolism protein#PC00031;general transcription factor#PC00259 HUMAN|HGNC=20277|UniProtKB=Q96FN9 Q96FN9 DTD2 PTHR10472:SF1 D-TYROSYL-TRNA TYR DEACYLASE D-AMINOACYL-TRNA DEACYLASE 2 deacylase activity#GO:0160215;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on RNA#GO:0140098;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity#GO:0016787;catalytic activity, acting on a tRNA#GO:0140101 cellular process#GO:0009987;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;esterase#PC00097;hydrolase#PC00121 HUMAN|HGNC=13144|UniProtKB=Q16587 Q16587 ZNF74 PTHR24377:SF336 IP01015P-RELATED ZINC FINGER PROTEIN 74 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=7954|UniProtKB=O95502 O95502 NPTXR PTHR19277:SF94 PENTRAXIN NEURONAL PENTRAXIN RECEPTOR scaffold/adaptor protein#PC00226 HUMAN|HGNC=3086|UniProtKB=O14641 O14641 DVL2 PTHR10878:SF8 SEGMENT POLARITY PROTEIN DISHEVELLED SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-2 G protein-coupled receptor binding#GO:0001664;frizzled binding#GO:0005109;binding#GO:0005488;signaling receptor binding#GO:0005102;protein binding#GO:0005515 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;Wnt signaling pathway#GO:0016055;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;canonical Wnt signaling pathway#GO:0060070;cell communication#GO:0007154 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 Angiogenesis#P00005>Dsh#P00200;Wnt signaling pathway#P00057>Dishevelled#P01447;Alzheimer disease-presenilin pathway#P00004>Dsh#P00132 HUMAN|HGNC=34026|UniProtKB=Q5VTU8 Q5VTU8 ATP5F1EP2 PTHR12448:SF2 ATP SYNTHASE EPSILON CHAIN, MITOCHONDRIAL ATP SYNTHASE SUBUNIT EPSILON-LIKE PROTEIN, MITOCHONDRIAL proton channel activity#GO:0015252;monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;ligase activity#GO:0016874;transmembrane transporter activity#GO:0022857;proton transmembrane transporter activity#GO:0015078;catalytic activity#GO:0003824;passive transmembrane transporter activity#GO:0022803;channel activity#GO:0015267;proton-transporting ATP synthase activity, rotational mechanism#GO:0046933;monoatomic cation transmembrane transporter activity#GO:0008324 cellular respiration#GO:0045333;organophosphate biosynthetic process#GO:0090407;oxidative phosphorylation#GO:0006119;aerobic respiration#GO:0009060;purine nucleoside triphosphate biosynthetic process#GO:0009145;nucleoside triphosphate metabolic process#GO:0009141;nucleoside phosphate metabolic process#GO:0006753;proton motive force-driven ATP synthesis#GO:0015986;primary metabolic process#GO:0044238;purine nucleoside triphosphate metabolic process#GO:0009144;energy derivation by oxidation of organic compounds#GO:0015980;nucleoside phosphate biosynthetic process#GO:1901293;generation of precursor metabolites and energy#GO:0006091;purine ribonucleoside triphosphate biosynthetic process#GO:0009206;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;nucleoside triphosphate biosynthetic process#GO:0009142;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;purine ribonucleoside triphosphate metabolic process#GO:0009205;carbohydrate derivative metabolic process#GO:1901135;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;nucleotide biosynthetic process#GO:0009165;ribonucleotide metabolic process#GO:0009259;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;small molecule metabolic process#GO:0044281;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521;proton motive force-driven mitochondrial ATP synthesis#GO:0042776;purine nucleotide metabolic process#GO:0006163;carbohydrate derivative biosynthetic process#GO:1901137;ribonucleoside triphosphate biosynthetic process#GO:0009201;nucleobase-containing small molecule metabolic process#GO:0055086;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;ATP biosynthetic process#GO:0006754;ribose phosphate biosynthetic process#GO:0046390;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020 ATP synthase#PC00002 HUMAN|HGNC=16941|UniProtKB=O76038 O76038 SCGN PTHR19972:SF15 CALBINDIN SECRETAGOGIN ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;calcium ion binding#GO:0005509;metal ion binding#GO:0046872;cation binding#GO:0043169 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;dendrite#GO:0030425;axon#GO:0030424;dendritic tree#GO:0097447;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;synapse#GO:0045202;neuron projection terminus#GO:0044306;cell projection#GO:0042995;distal axon#GO:0150034;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;terminal bouton#GO:0043195;cell junction#GO:0030054;axon terminus#GO:0043679;somatodendritic compartment#GO:0036477;cytoplasm#GO:0005737;cytosol#GO:0005829;presynapse#GO:0098793;neuron projection#GO:0043005;nucleus#GO:0005634 calmodulin-related#PC00061 HUMAN|HGNC=29530|UniProtKB=Q96AC6 Q96AC6 KIFC2 PTHR24115:SF479 KINESIN-RELATED KINESIN-LIKE PROTEIN KIFC2 pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543;tubulin binding#GO:0015631;isomerase activity#GO:0016853;ribonucleoside triphosphate phosphatase activity#GO:0017111;microtubule binding#GO:0008017;polypeptide conformation or assembly isomerase activity#GO:0120544;hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887;microtubule motor activity#GO:0003777;cytoskeletal protein binding#GO:0008092;hydrolase activity, acting on acid anhydrides#GO:0016817;cytoskeletal motor activity#GO:0003774;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;ATP-dependent activity#GO:0140657;protein binding#GO:0005515 cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;mitotic sister chromatid segregation#GO:0000070;spindle assembly#GO:0051225;cellular process#GO:0009987;mitotic spindle assembly#GO:0090307;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;chromosome segregation#GO:0007059;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;mitotic cell cycle process#GO:1903047;microtubule-based process#GO:0007017;chromosome organization#GO:0051276;cell cycle#GO:0007049;membraneless organelle assembly#GO:0140694;microtubule cytoskeleton organization involved in mitosis#GO:1902850;sister chromatid segregation#GO:0000819;cellular component organization#GO:0016043;nuclear chromosome segregation#GO:0098813;mitotic nuclear division#GO:0140014;cell cycle process#GO:0022402;mitotic cell cycle#GO:0000278;microtubule-based movement#GO:0007018;mitotic spindle organization#GO:0007052;organelle assembly#GO:0070925;nuclear division#GO:0000280;microtubule cytoskeleton organization#GO:0000226;organelle fission#GO:0048285 polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;spindle#GO:0005819;microtubule organizing center#GO:0005815;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;supramolecular complex#GO:0099080;nucleus#GO:0005634;microtubule cytoskeleton#GO:0015630;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membrane-bounded organelle#GO:0043227;microtubule#GO:0005874;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;mitotic spindle#GO:0072686;cellular anatomical structure#GO:0110165;organelle#GO:0043226 microtubule or microtubule-binding cytoskeletal protein#PC00157;microtubule binding motor protein#PC00156 HUMAN|HGNC=2874|UniProtKB=P15559 P15559 NQO1 PTHR10204:SF1 NAD P H OXIDOREDUCTASE-RELATED NAD(P)H DEHYDROGENASE [QUINONE] 1 oxidoreductase activity, acting on NAD(P)H#GO:0016651;NAD(P)H dehydrogenase (quinone) activity#GO:0003955;oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor#GO:0016655;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 oxidoreductase#PC00176 HUMAN|HGNC=13625|UniProtKB=Q9BXT2 Q9BXT2 CACNG6 PTHR15025:SF6 VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-1 SUBUNIT-RELATED VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-6 SUBUNIT transporter regulator activity#GO:0141108;calcium channel regulator activity#GO:0005246;ion channel regulator activity#GO:0099106;molecular function regulator activity#GO:0098772;channel regulator activity#GO:0016247 regulation of monoatomic cation transmembrane transport#GO:1904062;regulation of localization#GO:0032879;regulation of transport#GO:0051049;regulation of monoatomic ion transmembrane transport#GO:0034765;regulation of biological process#GO:0050789;regulation of transmembrane transport#GO:0034762;regulation of calcium ion transport#GO:0051924;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of metal ion transport#GO:0010959;regulation of monoatomic ion transport#GO:0043269 membrane protein complex#GO:0098796;voltage-gated calcium channel complex#GO:0005891;membrane#GO:0016020;calcium channel complex#GO:0034704;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane#GO:0005886;cation channel complex#GO:0034703;sarcolemma#GO:0042383;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351 voltage-gated ion channel#PC00241;transporter#PC00227 HUMAN|HGNC=5560|UniProtKB=P0DTW3 P0DTW3 IGHV1-38-4 PTHR23266:SF297 IMMUNOGLOBULIN HEAVY CHAIN NON-FUNCTIONAL IMMUNOGLOBULIN HEAVY VARIABLE 1-38-4-RELATED binding#GO:0005488;antigen binding#GO:0003823 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449;immune effector process#GO:0002252;immune system process#GO:0002376;adaptive immune response#GO:0002250;response to stimulus#GO:0050896;immune response#GO:0006955 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=16391|UniProtKB=Q9H257 Q9H257 CARD9 PTHR14559:SF3 CASPASE RECRUITMENT DOMAIN FAMILY CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 9 signaling adaptor activity#GO:0035591;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of canonical NF-kappaB signal transduction#GO:0043123;regulation of canonical NF-kappaB signal transduction#GO:0043122;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of cellular process#GO:0048522;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;regulation of signaling#GO:0023051;regulation of immune response#GO:0050776;regulation of intracellular signal transduction#GO:1902531;positive regulation of signaling#GO:0023056;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;signaling#GO:0023052;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of immune system process#GO:0002682;response to stimulus#GO:0050896 intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=12524|UniProtKB=Q16739 Q16739 UGCG PTHR12726:SF0 CERAMIDE GLUCOSYLTRANSFERASE CERAMIDE GLUCOSYLTRANSFERASE glucosyltransferase activity#GO:0046527;glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194;UDP-glucosyltransferase activity#GO:0035251;hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740 carbohydrate derivative biosynthetic process#GO:1901137;sphingolipid biosynthetic process#GO:0030148;metabolic process#GO:0008152;sphingolipid metabolic process#GO:0006665;lipid metabolic process#GO:0006629;ceramide biosynthetic process#GO:0046513;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;ceramide metabolic process#GO:0006672;glycolipid biosynthetic process#GO:0009247;glycosphingolipid biosynthetic process#GO:0006688;glycolipid metabolic process#GO:0006664;liposaccharide metabolic process#GO:1903509;primary metabolic process#GO:0044238 membrane#GO:0016020;cellular anatomical structure#GO:0110165 glycosyltransferase#PC00111 HUMAN|HGNC=13261|UniProtKB=Q5W186 Q5W186 CST9 PTHR46945:SF4 CYSTATIN-9-LIKE CYSTATIN-9 antimicrobial humoral response#GO:0019730;humoral immune response#GO:0006959;immune system process#GO:0002376;defense response#GO:0006952;response to external stimulus#GO:0009605;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;immune response#GO:0006955;defense response to symbiont#GO:0140546;defense response to other organism#GO:0098542;response to stimulus#GO:0050896;response to other organism#GO:0051707;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=14025|UniProtKB=Q9GZV3 Q9GZV3 SLC5A7 PTHR45897:SF2 HIGH-AFFINITY CHOLINE TRANSPORTER 1 HIGH AFFINITY CHOLINE TRANSPORTER 1 symporter activity#GO:0015293;solute:sodium symporter activity#GO:0015370;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;secondary active transmembrane transporter activity#GO:0015291;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081 cellular process#GO:0009987;synaptic signaling#GO:0099536;nitrogen compound transport#GO:0071705;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;biosynthetic process#GO:0009058;synaptic transmission, cholinergic#GO:0007271;transport#GO:0006810;neuromuscular synaptic transmission#GO:0007274;metabolic process#GO:0008152;establishment of localization#GO:0051234;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;signaling#GO:0023052;anterograde trans-synaptic signaling#GO:0098916;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;localization#GO:0051179 plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;cell periphery#GO:0071944;neuron projection#GO:0043005;membrane#GO:0016020;perikaryon#GO:0043204;cell junction#GO:0030054;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;neuronal cell body#GO:0043025;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell body#GO:0044297;dendritic tree#GO:0097447;axon#GO:0030424;dendrite#GO:0030425 transporter#PC00227 Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>CHT1#P01084;Nicotinic acetylcholine receptor signaling pathway#P00044>CHT1#P01098;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>CHT1#P01072 HUMAN|HGNC=4926|UniProtKB=O15212 O15212 PFDN6 PTHR21431:SF0 PREFOLDIN SUBUNIT 6 PREFOLDIN SUBUNIT 6 protein binding#GO:0005515;protein-folding chaperone binding#GO:0051087;binding#GO:0005488 protein maturation#GO:0051604;gene expression#GO:0010467;protein folding#GO:0006457;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 HUMAN|HGNC=12942|UniProtKB=P51786 P51786 ZNF157 PTHR24377:SF34 IP01015P-RELATED ZINC FINGER PROTEIN 157 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=9021|UniProtKB=P14618 P14618 PKM PTHR11817:SF101 PYRUVATE KINASE PYRUVATE KINASE PKM catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773;pyruvate kinase activity#GO:0004743 glycolytic process#GO:0006096;purine ribonucleoside triphosphate metabolic process#GO:0009205;organophosphate metabolic process#GO:0019637;response to peptide hormone#GO:0043434;cellular response to insulin stimulus#GO:0032869;purine ribonucleoside diphosphate metabolic process#GO:0009179;generation of precursor metabolites and energy#GO:0006091;ADP metabolic process#GO:0046031;purine nucleoside triphosphate metabolic process#GO:0009144;cellular response to stimulus#GO:0051716;response to insulin#GO:0032868;primary metabolic process#GO:0044238;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate derivative catabolic process#GO:1901136;nucleoside phosphate catabolic process#GO:1901292;pyridine-containing compound metabolic process#GO:0072524;nucleoside diphosphate metabolic process#GO:0009132;aerobic respiration#GO:0009060;purine ribonucleoside diphosphate catabolic process#GO:0009181;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;ADP catabolic process#GO:0046032;purine nucleoside diphosphate catabolic process#GO:0009137;nucleobase-containing small molecule metabolic process#GO:0055086;pyridine-containing compound catabolic process#GO:0072526;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;monocarboxylic acid metabolic process#GO:0032787;pyruvate metabolic process#GO:0006090;cellular response to hormone stimulus#GO:0032870;response to stimulus#GO:0050896;purine nucleoside diphosphate metabolic process#GO:0009135;ribonucleotide metabolic process#GO:0009259;cellular response to chemical stimulus#GO:0070887;carbohydrate catabolic process#GO:0016052;nucleotide metabolic process#GO:0009117;ribonucleotide catabolic process#GO:0009261;carbohydrate derivative metabolic process#GO:1901135;nucleobase-containing compound catabolic process#GO:0034655;nucleobase-containing compound metabolic process#GO:0006139;cellular response to nitrogen compound#GO:1901699;nucleotide catabolic process#GO:0009166;energy derivation by oxidation of organic compounds#GO:0015980;nucleoside diphosphate catabolic process#GO:0009134;purine ribonucleotide catabolic process#GO:0009154;nucleoside phosphate metabolic process#GO:0006753;cellular response to peptide hormone stimulus#GO:0071375;carbohydrate metabolic process#GO:0005975;catabolic process#GO:0009056;purine nucleotide catabolic process#GO:0006195;response to nitrogen compound#GO:1901698;cellular respiration#GO:0045333;ribonucleoside diphosphate catabolic process#GO:0009191;organophosphate catabolic process#GO:0046434;ATP metabolic process#GO:0046034;nicotinamide nucleotide metabolic process#GO:0046496;response to hormone#GO:0009725;response to chemical#GO:0042221;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;purine-containing compound catabolic process#GO:0072523;ribonucleoside diphosphate metabolic process#GO:0009185;carboxylic acid metabolic process#GO:0019752;phosphorus metabolic process#GO:0006793;response to endogenous stimulus#GO:0009719;pyridine nucleotide catabolic process#GO:0019364;cellular response to endogenous stimulus#GO:0071495;small molecule metabolic process#GO:0044281;response to oxygen-containing compound#GO:1901700;oxoacid metabolic process#GO:0043436 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 kinase#PC00137 Glycolysis#P00024>Pyruvate kinase#P00675;Pyruvate metabolism#P02772>Pyruvate Kinase#P03132 HUMAN|HGNC=469|UniProtKB=Q01433 Q01433 AMPD2 PTHR11359:SF3 AMP DEAMINASE AMP DEAMINASE 2 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;deaminase activity#GO:0019239;catalytic activity#GO:0003824 nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide biosynthetic process#GO:0009165;nucleoside monophosphate biosynthetic process#GO:0009124;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;ribonucleotide metabolic process#GO:0009259;small molecule metabolic process#GO:0044281;purine ribonucleoside monophosphate metabolic process#GO:0009167;phosphorus metabolic process#GO:0006793;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;carbohydrate derivative biosynthetic process#GO:1901137;purine nucleoside monophosphate metabolic process#GO:0009126;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;ribose phosphate biosynthetic process#GO:0046390;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;IMP biosynthetic process#GO:0006188;organophosphate biosynthetic process#GO:0090407;IMP metabolic process#GO:0046040;nucleoside monophosphate metabolic process#GO:0009123;nucleoside phosphate metabolic process#GO:0006753;primary metabolic process#GO:0044238;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;carbohydrate derivative metabolic process#GO:1901135 deaminase#PC00088 HUMAN|HGNC=19156|UniProtKB=Q8NFW9 Q8NFW9 MYRIP PTHR14555:SF6 MYELIN-ASSOCIATED OLIGODENDROCYTIC BASIC PROTEIN MOBP -RELATED RAB EFFECTOR MYRIP actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;myosin binding#GO:0017022;protein binding#GO:0005515 intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;cortical actin cytoskeleton#GO:0030864;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell cortex#GO:0005938;cell periphery#GO:0071944;actin cytoskeleton#GO:0015629;cortical cytoskeleton#GO:0030863;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 myelin protein#PC00161 HUMAN|HGNC=14270|UniProtKB=Q8TAB3 Q8TAB3 PCDH19 PTHR24028:SF40 CADHERIN-87A PROTOCADHERIN-19 cellular process#GO:0009987;cell adhesion#GO:0007155 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 cell adhesion molecule#PC00069;cadherin#PC00057 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HUMAN|HGNC=10004|UniProtKB=O75916 O75916 RGS9 PTHR45746:SF1 LP21163P REGULATOR OF G PROTEIN SIGNALING 9 molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;enzyme activator activity#GO:0008047 G protein-coupled dopamine receptor signaling pathway#GO:0007212;cellular process#GO:0009987;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;cellular response to nitrogen compound#GO:1901699;response to chemical#GO:0042221;biological regulation#GO:0065007;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887;response to oxygen-containing compound#GO:1901700;cell communication#GO:0007154;response to nitrogen compound#GO:1901698 intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>RGS#P00704;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>RGS9#P00749;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>RGS#P00731 HUMAN|HGNC=25403|UniProtKB=Q6UVJ0 Q6UVJ0 SASS6 PTHR44281:SF4 SPINDLE ASSEMBLY ABNORMAL PROTEIN 6 HOMOLOG SPINDLE ASSEMBLY ABNORMAL PROTEIN 6 HOMOLOG developmental process#GO:0032502;spermatogenesis#GO:0007283;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;centrosome duplication#GO:0051298;microtubule organizing center organization#GO:0031023;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;male gamete generation#GO:0048232;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;organelle assembly#GO:0070925;sexual reproduction#GO:0019953;centriole replication#GO:0007099;microtubule cytoskeleton organization#GO:0000226;multicellular organismal reproductive process#GO:0048609;membraneless organelle assembly#GO:0140694;developmental process involved in reproduction#GO:0003006;cellular component organization#GO:0016043;cell cycle#GO:0007049;cell cycle process#GO:0022402;centrosome cycle#GO:0007098;gamete generation#GO:0007276;reproductive process#GO:0022414 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;centriole#GO:0005814;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;centrosome#GO:0005813;intracellular organelle#GO:0043229 HUMAN|HGNC=9865|UniProtKB=P10826 P10826 RARB PTHR24082:SF286 NUCLEAR HORMONE RECEPTOR RETINOIC ACID RECEPTOR BETA RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;molecular transducer activity#GO:0060089;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;nuclear receptor activity#GO:0004879;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulator activity#GO:0140110;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023 negative regulation of metabolic process#GO:0009892;signaling#GO:0023052;cell differentiation#GO:0030154;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;cellular response to endogenous stimulus#GO:0071495;cellular response to hormone stimulus#GO:0032870;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;negative regulation of biological process#GO:0048519;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;negative regulation of DNA-templated transcription#GO:0045892;hormone-mediated signaling pathway#GO:0009755;cellular response to chemical stimulus#GO:0070887;positive regulation of macromolecule metabolic process#GO:0010604;response to chemical#GO:0042221;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;response to hormone#GO:0009725;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;positive regulation of transcription by RNA polymerase II#GO:0045944;intracellular receptor signaling pathway#GO:0030522;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;nuclear receptor-mediated signaling pathway#GO:0141193;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523 RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular anatomical structure#GO:0005622 C4 zinc finger nuclear receptor#PC00169 HUMAN|HGNC=2013|UniProtKB=Q92572 Q92572 AP3S1 PTHR11753:SF12 ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY AP-3 COMPLEX SUBUNIT SIGMA-1 cellular process#GO:0009987;transport#GO:0006810;establishment of localization#GO:0051234;vesicle-mediated transport#GO:0016192;localization#GO:0051179 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 vesicle coat protein#PC00235;membrane traffic protein#PC00150 HUMAN|HGNC=18905|UniProtKB=Q9BYT5 Q9BYT5 KRTAP2-2 PTHR23262:SF7 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 2-2-RELATED structural protein#PC00211 HUMAN|HGNC=20871|UniProtKB=Q5SZJ8 Q5SZJ8 BEND6 PTHR35346:SF1 BEN DOMAIN-CONTAINING PROTEIN 6 BEN DOMAIN-CONTAINING PROTEIN 6 transcription regulator activity#GO:0140110;transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712 negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;regulation of Notch signaling pathway#GO:0008593;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of developmental process#GO:0050793;negative regulation of cellular process#GO:0048523;positive regulation of cell differentiation#GO:0045597;regulation of response to stimulus#GO:0048583;regulation of cell differentiation#GO:0045595;positive regulation of developmental process#GO:0051094;negative regulation of Notch signaling pathway#GO:0045746;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of neuron differentiation#GO:0045664;negative regulation of response to stimulus#GO:0048585;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 DNA-binding transcription factor#PC00218;winged helix/forkhead transcription factor#PC00246 HUMAN|HGNC=12214|UniProtKB=A0A0K0K1B3 A0A0K0K1B3 TRBV30 PTHR23268:SF31 T-CELL RECEPTOR BETA CHAIN T CELL RECEPTOR BETA VARIABLE 30 cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=21629|UniProtKB=Q8TAF7 Q8TAF7 ZNF461 PTHR24377:SF277 IP01015P-RELATED ZINC FINGER PROTEIN 461 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=11993|UniProtKB=O95985 O95985 TOP3B PTHR11390:SF20 PROKARYOTIC DNA TOPOISOMERASE DNA TOPOISOMERASE 3-BETA-1 macromolecular conformation isomerase activity#GO:0120543;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity#GO:0003824;isomerase activity#GO:0016853;catalytic activity, acting on DNA#GO:0140097 nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;response to stress#GO:0006950;organelle organization#GO:0006996;chromosome organization#GO:0051276;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;DNA damage response#GO:0006974;DNA recombination#GO:0006310;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;cellular response to stress#GO:0033554 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA metabolism protein#PC00009 HUMAN|HGNC=20990|UniProtKB=Q9C0D0 Q9C0D0 PHACTR1 PTHR12751:SF6 PHOSPHATASE AND ACTIN REGULATOR PHACTR PHOSPHATASE AND ACTIN REGULATOR 1 binding#GO:0005488;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515 cell motility#GO:0048870;actin cytoskeleton organization#GO:0030036;actomyosin structure organization#GO:0031032;cellular component organization#GO:0016043;actin filament bundle organization#GO:0061572;actin filament bundle assembly#GO:0051017;stress fiber assembly#GO:0043149;supramolecular fiber organization#GO:0097435;actin filament-based process#GO:0030029;contractile actin filament bundle assembly#GO:0030038;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;actin filament organization#GO:0007015 phosphatase modulator#PC00184 HUMAN|HGNC=28948|UniProtKB=Q5BJD5 Q5BJD5 TMEM41B PTHR43220:SF18 FAMILY NOT NAMED TRANSMEMBRANE PROTEIN 41B organelle assembly#GO:0070925;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;autophagosome assembly#GO:0000045;process utilizing autophagic mechanism#GO:0061919;vacuole organization#GO:0007033;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;autophagosome organization#GO:1905037;autophagy#GO:0006914;catabolic process#GO:0009056;cellular component assembly#GO:0022607;macroautophagy#GO:0016236 membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=4553|UniProtKB=P07203 P07203 GPX1 PTHR11592:SF41 GLUTATHIONE PEROXIDASE GLUTATHIONE PEROXIDASE 1 oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on peroxide as acceptor#GO:0016684;peroxidase activity#GO:0004601;antioxidant activity#GO:0016209;catalytic activity#GO:0003824 response to chemical#GO:0042221;cellular response to oxidative stress#GO:0034599;cellular process#GO:0009987;response to stress#GO:0006950;sulfur compound metabolic process#GO:0006790;response to reactive oxygen species#GO:0000302;response to oxidative stress#GO:0006979;cellular response to chemical stress#GO:0062197;metabolic process#GO:0008152;reactive oxygen species metabolic process#GO:0072593;hydrogen peroxide metabolic process#GO:0042743;catabolic process#GO:0009056;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;modified amino acid metabolic process#GO:0006575;cellular response to stress#GO:0033554;response to oxygen-containing compound#GO:1901700;cellular response to chemical stimulus#GO:0070887;glutathione metabolic process#GO:0006749 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;cytosol#GO:0005829 peroxidase#PC00180;oxidoreductase#PC00176 HUMAN|HGNC=16651|UniProtKB=Q9BRJ2 Q9BRJ2 MRPL45 PTHR28554:SF1 39S RIBOSOMAL PROTEIN L45, MITOCHONDRIAL LARGE RIBOSOMAL SUBUNIT PROTEIN ML45 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 ribosomal protein#PC00202;translational protein#PC00263 HUMAN|HGNC=43771|UniProtKB=P0DJG4 P0DJG4 SPMAP2L PTHR15901:SF15 TESTICULAR HAPLOID EXPRESSED GENE PROTEIN SPERM MICROTUBULE ASSOCIATED PROTEIN 2-LIKE HUMAN|HGNC=25285|UniProtKB=Q5GAN3 Q5GAN3 RNASE13 PTHR11437:SF11 RIBONUCLEASE INACTIVE RIBONUCLEASE-LIKE PROTEIN 13-RELATED catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;nuclease activity#GO:0004518;RNA nuclease activity#GO:0004540;catalytic activity, acting on RNA#GO:0140098 defense response to bacterium#GO:0042742;response to bacterium#GO:0009617;defense response#GO:0006952;response to external stimulus#GO:0009605;defense response to Gram-positive bacterium#GO:0050830;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;response to other organism#GO:0051707;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to stimulus#GO:0050896 RNA metabolism protein#PC00031;endoribonuclease#PC00094 HUMAN|HGNC=80|UniProtKB=P19801 P19801 AOC1 PTHR10638:SF3 COPPER AMINE OXIDASE DIAMINE OXIDASE [COPPER-CONTAINING] catalytic activity#GO:0003824;copper ion binding#GO:0005507;oxidoreductase activity#GO:0016491;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;transition metal ion binding#GO:0046914;metal ion binding#GO:0046872;cation binding#GO:0043169 metabolic process#GO:0008152;amine metabolic process#GO:0009308;polyamine metabolic process#GO:0006595;cellular process#GO:0009987;biogenic amine metabolic process#GO:0006576 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 oxidase#PC00175;oxidoreductase#PC00176 Phenylethylamine degradation#P02766>Phenylethylamine oxidase#P03103 HUMAN|HGNC=121|UniProtKB=O15254 O15254 ACOX3 PTHR10909:SF390 ELECTRON TRANSPORT OXIDOREDUCTASE PEROXISOMAL ACYL-COENZYME A OXIDASE 3 ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265;small molecule binding#GO:0036094;anion binding#GO:0043168;flavin adenine dinucleotide binding#GO:0050660;binding#GO:0005488;carboxylic acid binding#GO:0031406;organic acid binding#GO:0043177;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;fatty acid binding#GO:0005504;lipid binding#GO:0008289;catalytic activity#GO:0003824;heterocyclic compound binding#GO:1901363;oxidoreductase activity#GO:0016491;nucleotide binding#GO:0000166 fatty acid oxidation#GO:0019395;lipid metabolic process#GO:0006629;fatty acid beta-oxidation#GO:0006635;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;lipid modification#GO:0030258;lipid catabolic process#GO:0016042;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;monocarboxylic acid catabolic process#GO:0072329;oxoacid metabolic process#GO:0043436;fatty acid catabolic process#GO:0009062;lipid oxidation#GO:0034440;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;small molecule catabolic process#GO:0044282;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;peroxisome#GO:0005777;microbody#GO:0042579 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=12785|UniProtKB=Q9Y6F9 Q9Y6F9 WNT6 PTHR12027:SF72 WNT RELATED PROTEIN WNT-6 cytokine activity#GO:0005125;binding#GO:0005488;signaling receptor binding#GO:0005102;molecular function activator activity#GO:0140677;protein binding#GO:0005515;frizzled binding#GO:0005109;G protein-coupled receptor binding#GO:0001664;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772 cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;response to stimulus#GO:0050896;Wnt signaling pathway#GO:0016055;signaling#GO:0023052;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;anatomical structure development#GO:0048856;cell communication#GO:0007154;canonical Wnt signaling pathway#GO:0060070;cell fate commitment#GO:0045165;system development#GO:0048731;cellular process#GO:0009987;signal transduction#GO:0007165;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;biological regulation#GO:0065007;cell surface receptor signaling pathway#GO:0007166;neuron differentiation#GO:0030182;developmental process#GO:0032502;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;neurogenesis#GO:0022008 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 Cadherin signaling pathway#P00012>Wnt#P00474;Wnt signaling pathway#P00057>Wnt#P01444;Alzheimer disease-presenilin pathway#P00004>Wnt#P00142 HUMAN|HGNC=27087|UniProtKB=Q8NHV5 Q8NHV5 MOSMO PTHR31186:SF1 MODULATOR OF SMOOTHENED PROTEIN MODULATOR OF SMOOTHENED PROTEIN regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;negative regulation of response to stimulus#GO:0048585;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of cell communication#GO:0010648;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;negative regulation of signaling#GO:0023057;negative regulation of cellular process#GO:0048523 organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;Golgi apparatus#GO:0005794;endomembrane system#GO:0012505;plasma membrane region#GO:0098590;ciliary membrane#GO:0060170;cytoplasm#GO:0005737;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;cell projection membrane#GO:0031253;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cilium#GO:0005929;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;cell projection#GO:0042995 HUMAN|HGNC=17634|UniProtKB=Q7Z417 Q7Z417 NUFIP2 PTHR28333:SF2 NUCLEAR FRAGILE X MENTAL RETARDATION-INTERACTING PROTEIN 2 FMR1-INTERACTING PROTEIN NUFIP2 nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;nucleoplasm#GO:0005654;organelle#GO:0043226;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membraneless organelle#GO:0043228;cytoplasmic stress granule#GO:0010494;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 HUMAN|HGNC=16132|UniProtKB=Q9BYN0 Q9BYN0 SRXN1 PTHR21348:SF4 FAMILY NOT NAMED SULFIREDOXIN-1 antioxidant activity#GO:0016209;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 response to stimulus#GO:0050896;response to chemical#GO:0042221;cellular response to oxidative stress#GO:0034599;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stress#GO:0006950;cellular response to chemical stress#GO:0062197;response to oxidative stress#GO:0006979;cellular response to stress#GO:0033554;cellular response to chemical stimulus#GO:0070887 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 HUMAN|HGNC=27172|UniProtKB=Q75VX8 Q75VX8 GAREM2 PTHR14454:SF5 GRB2-ASSOCIATED AND REGULATOR OF MAPK PROTEIN FAMILY MEMBER GRB2-ASSOCIATED AND REGULATOR OF MAPK PROTEIN 2 HUMAN|HGNC=8791|UniProtKB=Q13946 Q13946 PDE7A PTHR11347:SF96 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE HIGH AFFINITY 3',5'-CYCLIC-AMP PHOSPHODIESTERASE 7A cyclic-nucleotide phosphodiesterase activity#GO:0004112;hydrolase activity#GO:0016787;phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of cell communication#GO:0010646;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;negative regulation of response to stimulus#GO:0048585;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;negative regulation of cellular process#GO:0048523;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532 phosphodiesterase#PC00185;hydrolase#PC00121 HUMAN|HGNC=26685|UniProtKB=Q8N9Z2 Q8N9Z2 CCDC71L PTHR14484:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 71 COILED-COIL DOMAIN-CONTAINING PROTEIN 71L HUMAN|HGNC=7590|UniProtKB=Q15746 Q15746 MYLK PTHR47633:SF1 IMMUNOGLOBULIN MYOSIN LIGHT CHAIN KINASE, SMOOTH MUSCLE phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 muscle system process#GO:0003012;muscle contraction#GO:0006936;system process#GO:0003008;multicellular organismal process#GO:0032501 cleavage furrow#GO:0032154;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;stress fiber#GO:0001725;cell division site#GO:0032153;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;cytoplasm#GO:0005737;plasma membrane region#GO:0098590;lamellipodium#GO:0030027;cell periphery#GO:0071944;actomyosin#GO:0042641;cell leading edge#GO:0031252;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;actin filament bundle#GO:0032432;intracellular organelle#GO:0043229;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;actin cytoskeleton#GO:0015629 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>MLCK#P00877;Cytoskeletal regulation by Rho GTPase#P00016>MLCK#P00514 HUMAN|HGNC=21030|UniProtKB=Q53QZ3 Q53QZ3 ARHGAP15 PTHR23176:SF108 RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN RHO GTPASE-ACTIVATING PROTEIN 15 enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;intracellular signaling cassette#GO:0141124;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789 plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 GTPase-activating protein#PC00257 PDGF signaling pathway#P00047>Rho#P01174 HUMAN|HGNC=8135|UniProtKB=P23515 P23515 OMG PTHR47114:SF2 FAMILY NOT NAMED OLIGODENDROCYTE-MYELIN GLYCOPROTEIN multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;developmental process#GO:0032502;neuron differentiation#GO:0030182;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;regeneration#GO:0031099;plasma membrane bounded cell projection organization#GO:0120036;neuron projection development#GO:0031175;response to stress#GO:0006950;cellular process#GO:0009987;anatomical structure development#GO:0048856;system development#GO:0048731;neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;cellular response to stress#GO:0033554;generation of neurons#GO:0048699;cell differentiation#GO:0030154;response to stimulus#GO:0050896;cell projection organization#GO:0030030;cell development#GO:0048468;cellular component organization#GO:0016043;cellular response to stimulus#GO:0051716 HUMAN|HGNC=27442|UniProtKB=Q8N413 Q8N413 SLC25A45 PTHR45624:SF6 MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED METHYLATED AMINO-ACID TRANSPORTER SLC25A45 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 transporter#PC00227 HUMAN|HGNC=33177|UniProtKB=Q5MJ08 Q5MJ08 SPANXN4 PTHR23425:SF2 NUCLEOPORIN AMO1-LIKE SPERM PROTEIN ASSOCIATED WITH THE NUCLEUS ON THE X CHROMOSOME N4 transporter#PC00227 HUMAN|HGNC=5741|UniProtKB=P01602 P01602 IGKV1-5 PTHR23267:SF373 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN KAPPA VARIABLE 1-5 response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=23159|UniProtKB=Q9H553 Q9H553 ALG2 PTHR45918:SF1 ALPHA-1,3/1,6-MANNOSYLTRANSFERASE ALG2 ALPHA-1,3_1,6-MANNOSYLTRANSFERASE ALG2 metabolite interconversion enzyme#PC00262;transferase#PC00220 HUMAN|HGNC=16491|UniProtKB=Q9HB75 Q9HB75 PIDD1 PTHR45752:SF44 LEUCINE-RICH REPEAT-CONTAINING P53-INDUCED DEATH DOMAIN-CONTAINING PROTEIN 1 programmed cell death#GO:0012501;cell death#GO:0008219;apoptotic process#GO:0006915;cellular process#GO:0009987 scaffold/adaptor protein#PC00226 HUMAN|HGNC=30908|UniProtKB=Q8WXG1 Q8WXG1 RSAD2 PTHR21339:SF0 RADICAL S-ADENOSYL METHIONINE DOMAIN-CONTAINING PROTEIN 2 S-ADENOSYLMETHIONINE-DEPENDENT NUCLEOTIDE DEHYDRATASE RSAD2 iron-sulfur cluster binding#GO:0051536;small molecule binding#GO:0036094;binding#GO:0005488 defense response to virus#GO:0051607;regulation of biological process#GO:0050789;regulation of immune system process#GO:0002682;response to stimulus#GO:0050896;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;regulation of immune response#GO:0050776;response to virus#GO:0009615;response to stress#GO:0006950;positive regulation of immune system process#GO:0002684;response to biotic stimulus#GO:0009607;positive regulation of biological process#GO:0048518;positive regulation of response to stimulus#GO:0048584;response to other organism#GO:0051707;biological regulation#GO:0065007;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;defense response#GO:0006952;response to external stimulus#GO:0009605 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 HUMAN|HGNC=8017|UniProtKB=Q92636 Q92636 NSMAF PTHR13743:SF123 BEIGE/BEACH-RELATED PROTEIN FAN membrane#GO:0016020;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=1843|UniProtKB=Q9BXW7 Q9BXW7 HDHD5 PTHR14269:SF17 CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING 5 glycerolipid metabolic process#GO:0046486;glycerophospholipid metabolic process#GO:0006650;phospholipid biosynthetic process#GO:0008654;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;organophosphate metabolic process#GO:0019637;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987;organophosphate biosynthetic process#GO:0090407;metabolic process#GO:0008152;glycerophospholipid biosynthetic process#GO:0046474;lipid metabolic process#GO:0006629 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 transferase#PC00220;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=31419|UniProtKB=Q5T9C2 Q5T9C2 EEIG1 PTHR21456:SF2 FAMILY WITH SEQUENCE SIMILARITY 102 EARLY ESTROGEN-INDUCED GENE 1 PROTEIN HUMAN|HGNC=33715|UniProtKB=Q6ZUX3 Q6ZUX3 TOGARAM2 PTHR21567:SF42 CLASP TOG ARRAY REGULATOR OF AXONEMAL MICROTUBULES PROTEIN 2 cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;microtubule binding#GO:0008017;binding#GO:0005488;protein binding#GO:0005515 microtubule-based process#GO:0007017;cytoskeleton organization#GO:0007010;microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996 intracellular organelle#GO:0043229;cilium#GO:0005929;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membrane-bounded organelle#GO:0043227;cytoplasmic microtubule#GO:0005881;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cytoskeleton#GO:0005856;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232 microtubule or microtubule-binding cytoskeletal protein#PC00157;non-motor microtubule binding protein#PC00166;cytoskeletal protein#PC00085 HUMAN|HGNC=6106|UniProtKB=Q9BZS1 Q9BZS1 FOXP3 PTHR45796:SF5 FORKHEAD BOX P, ISOFORM C FORKHEAD BOX PROTEIN P3 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription repressor activity#GO:0001217 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 winged helix/forkhead transcription factor#PC00246;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=23510|UniProtKB=Q9NX94 Q9NX94 WBP1L PTHR16209:SF4 VESICULAR, OVEREXPRESSED IN CANCER, PROSURVIVAL PROTEIN 1 WW DOMAIN BINDING PROTEIN 1-LIKE biological regulation#GO:0065007;response to cytokine#GO:0034097;response to chemical#GO:0042221;cellular process#GO:0009987;signal transduction#GO:0007165;response to chemokine#GO:1990868;cell surface receptor signaling pathway#GO:0007166;cellular response to chemokine#GO:1990869;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;response to peptide#GO:1901652;cell communication#GO:0007154;chemokine-mediated signaling pathway#GO:0070098;G protein-coupled receptor signaling pathway#GO:0007186;cytokine-mediated signaling pathway#GO:0019221 HUMAN|HGNC=26107|UniProtKB=A5D8W1 A5D8W1 CFAP69 PTHR14716:SF0 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 69 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 69 positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;positive regulation of cell motility#GO:2000147;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;regulation of reproductive process#GO:2000241;regulation of microtubule-based movement#GO:0060632;response to stimulus#GO:0050896;response to chemical#GO:0042221;regulation of cellular process#GO:0050794;multicellular organismal process#GO:0032501;regulation of microtubule-based process#GO:0032886;positive regulation of locomotion#GO:0040017;regulation of cell motility#GO:2000145 9+2 motile cilium#GO:0097729;cilium#GO:0005929;non-motile cilium#GO:0097730;membrane-bounded organelle#GO:0043227;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;sperm flagellum#GO:0036126;cellular anatomical structure#GO:0110165;motile cilium#GO:0031514;organelle#GO:0043226 structural protein#PC00211 HUMAN|HGNC=16430|UniProtKB=Q9GZZ8 Q9GZZ8 LACRT PTHR40711:SF2 DERMCIDIN-RELATED EXTRACELLULAR GLYCOPROTEIN LACRITIN response to external stimulus#GO:0009605;defense response#GO:0006952;calcium-mediated signaling#GO:0019722;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124;response to other organism#GO:0051707;response to bacterium#GO:0009617;defense response to bacterium#GO:0042742;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;response to external biotic stimulus#GO:0043207;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419 intracellular vesicle#GO:0097708;secretory vesicle#GO:0099503;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;extracellular region#GO:0005576;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=19883|UniProtKB=Q6ZSB9 Q6ZSB9 ZBTB49 PTHR24399:SF72 ZINC FINGER AND BTB DOMAIN-CONTAINING ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 49 DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription repressor activity#GO:0001217;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulator activity#GO:0140110;sequence-specific DNA binding#GO:0043565 regulation of primary metabolic process#GO:0080090;regulation of cytokine production#GO:0001817;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of multicellular organismal process#GO:0051239;negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654 DNA-binding transcription factor#PC00218;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=14008|UniProtKB=Q9BW11 Q9BW11 MXD3 PTHR11969:SF6 MAX DIMERIZATION, MAD MAX DIMERIZATION PROTEIN 3 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 basic helix-loop-helix transcription factor#PC00055;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=10404|UniProtKB=P15880 P15880 RPS2 PTHR13718:SF93 RIBOSOMAL S SUBUNIT SMALL RIBOSOMAL SUBUNIT PROTEIN US5 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058;metabolic process#GO:0008152;translation#GO:0006412;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 ribosome#GO:0005840;cytosolic ribosome#GO:0022626;cytosol#GO:0005829;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;small ribosomal subunit#GO:0015935;intracellular organelle#GO:0043229;cytosolic small ribosomal subunit#GO:0022627;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 ribosomal protein#PC00202 HUMAN|HGNC=30491|UniProtKB=Q69YW2 Q69YW2 STUM PTHR21676:SF1 PROTEIN STUM PROTEIN STUM HOMOLOG HUMAN|HGNC=28572|UniProtKB=Q68DX3 Q68DX3 FRMPD2 PTHR19964:SF56 MULTIPLE PDZ DOMAIN PROTEIN FERM AND PDZ DOMAIN-CONTAINING PROTEIN 2 binding#GO:0005488;phospholipid binding#GO:0005543;lipid binding#GO:0008289 cell-cell junction assembly#GO:0007043;cell-cell junction organization#GO:0045216;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;cell junction assembly#GO:0034329;cell junction organization#GO:0034330;cellular component assembly#GO:0022607 cell junction#GO:0030054;tight junction#GO:0070160;apical junction complex#GO:0043296;apical part of cell#GO:0045177;plasma membrane region#GO:0098590;bicellular tight junction#GO:0005923;plasma membrane#GO:0005886;cytoplasm#GO:0005737;basolateral plasma membrane#GO:0016323;membrane#GO:0016020;cell-cell junction#GO:0005911;basal plasma membrane#GO:0009925;cell periphery#GO:0071944;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;cellular anatomical structure#GO:0110165;basal part of cell#GO:0045178 scaffold/adaptor protein#PC00226 HUMAN|HGNC=2037|UniProtKB=Q9Y5I7 Q9Y5I7 CLDN16 PTHR12002:SF56 CLAUDIN CLAUDIN-16 paracellular tight junction channel activity#GO:0160187;transporter activity#GO:0005215 localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;paracellular transport#GO:0160184;establishment of localization#GO:0051234;cell-cell junction organization#GO:0045216;cell-cell junction assembly#GO:0007043;transport#GO:0006810;cellular component assembly#GO:0022607;cell junction organization#GO:0034330;cellular component biogenesis#GO:0044085;cell junction assembly#GO:0034329;cellular component organization#GO:0016043;cellular process#GO:0009987 anchoring junction#GO:0070161;cell junction#GO:0030054;tight junction#GO:0070160;apical junction complex#GO:0043296;plasma membrane#GO:0005886;bicellular tight junction#GO:0005923;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;cell-cell junction#GO:0005911;membrane#GO:0016020 tight junction#PC00214;cell junction protein#PC00070 HUMAN|HGNC=25659|UniProtKB=A0A1B0GTU1 A0A1B0GTU1 ZC3H11B PTHR15725:SF13 ZN-FINGER, C-X8-C-X5-C-X3-H TYPE-CONTAINING ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 11B-RELATED RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729 RNA transport#GO:0050658;RNA localization#GO:0006403;nucleobase-containing compound transport#GO:0015931;mRNA transport#GO:0051028;establishment of RNA localization#GO:0051236;nucleocytoplasmic transport#GO:0006913;mRNA export from nucleus#GO:0006406;nucleic acid transport#GO:0050657;cellular localization#GO:0051641;localization#GO:0051179;nuclear export#GO:0051168;nuclear transport#GO:0051169;nitrogen compound transport#GO:0071705;macromolecule localization#GO:0033036;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907;metabolic process#GO:0008152;transport#GO:0006810;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;poly(A)+ mRNA export from nucleus#GO:0016973 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 RNA processing factor#PC00147 HUMAN|HGNC=17623|UniProtKB=Q9Y5A7 Q9Y5A7 NUB1 PTHR12948:SF3 NEDD8 ULTIMATE BUSTER-1 BS4 PROTEIN NEDD8 ULTIMATE BUSTER 1 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;regulation of protein catabolic process#GO:0042176;regulation of catabolic process#GO:0009894 HUMAN|HGNC=3004|UniProtKB=Q9BQC3 Q9BQC3 DPH2 PTHR10762:SF2 DIPHTHAMIDE BIOSYNTHESIS PROTEIN 2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2 metabolic process#GO:0008152;protein modification process#GO:0036211;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412 HUMAN|HGNC=21013|UniProtKB=Q6UX71 Q6UX71 PLXDC2 PTHR13055:SF11 TUMOR ENDOTHELIAL MARKER 7 RELATED PLEXIN DOMAIN-CONTAINING PROTEIN 2 HUMAN|HGNC=24138|UniProtKB=Q9UF47 Q9UF47 DNAJC5B PTHR44027:SF6 DNAJ HOMOLOG SUBFAMILY C MEMBER 5 HOMOLOG DNAJ HOMOLOG SUBFAMILY C MEMBER 5B chaperone#PC00072 HUMAN|HGNC=3032|UniProtKB=Q13474 Q13474 DRP2 PTHR12268:SF16 E3 UBIQUITIN-PROTEIN LIGASE KCMF1 DYSTROPHIN-RELATED PROTEIN 2 cell junction organization#GO:0034330;cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;cellular process#GO:0009987;synapse organization#GO:0050808 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane#GO:0005886;membrane protein complex#GO:0098796;membrane#GO:0016020;dystrophin-associated glycoprotein complex#GO:0016010;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=16989|UniProtKB=Q9UBU8 Q9UBU8 MORF4L1 PTHR10880:SF29 MORTALITY FACTOR 4-LIKE PROTEIN MORTALITY FACTOR 4-LIKE PROTEIN 1 chromatin binding#GO:0003682;binding#GO:0005488 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 intracellular protein-containing complex#GO:0140535;histone acetyltransferase complex#GO:0000123;membraneless organelle#GO:0043228;transferase complex#GO:1990234;intracellular membraneless organelle#GO:0043232;H4 histone acetyltransferase complex#GO:1902562;protein-containing complex#GO:0032991;NuA4 histone acetyltransferase complex#GO:0035267;chromatin#GO:0000785;intracellular anatomical structure#GO:0005622;acetyltransferase complex#GO:1902493;protein acetyltransferase complex#GO:0031248;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;chromosome#GO:0005694 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=14755|UniProtKB=Q8NG92 Q8NG92 OR13H1 PTHR26453:SF76 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 13H1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 sensory perception#GO:0007600;nervous system process#GO:0050877;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;detection of chemical stimulus#GO:0009593;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;response to chemical#GO:0042221;response to stimulus#GO:0050896;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=10298|UniProtKB=P27635 P27635 RPL10 PTHR11726:SF36 60S RIBOSOMAL PROTEIN L10 LARGE RIBOSOMAL SUBUNIT PROTEIN UL16 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;translation#GO:0006412;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;cytosol#GO:0005829;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625;ribosome#GO:0005840;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;intracellular organelle#GO:0043229 ribosomal protein#PC00202;translational protein#PC00263 HUMAN|HGNC=2377|UniProtKB=Q6P2C8 Q6P2C8 MED27 PTHR13130:SF4 34 KDA TRANSCRIPTIONAL CO-ACTIVATOR-RELATED MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 27 transcription coactivator activity#GO:0003713;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;mediator complex#GO:0016592;intracellular anatomical structure#GO:0005622 transcription cofactor#PC00217 HUMAN|HGNC=14504|UniProtKB=P82914 P82914 MRPS15 PTHR46685:SF1 28S RIBOSOMAL PROTEIN S15, MITOCHONDRIAL SMALL RIBOSOMAL SUBUNIT PROTEIN US15M ribosome#GO:0005840;mitochondrion#GO:0005739;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;small ribosomal subunit#GO:0015935;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;mitochondrial ribosome#GO:0005761;organellar ribosome#GO:0000313;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;mitochondrial small ribosomal subunit#GO:0005763;membraneless organelle#GO:0043228 ribosomal protein#PC00202;translational protein#PC00263 HUMAN|HGNC=9524|UniProtKB=Q13046 Q13046 PSG7 PTHR44427:SF19 CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 19 PREGNANCY-SPECIFIC BETA-1-GLYCOPROTEIN 7 cell adhesion molecule#PC00069 HUMAN|HGNC=32934|UniProtKB=G3V0H7 G3V0H7 SLCO1B7 PTHR11388:SF154 ORGANIC ANION TRANSPORTER SLCO1B3-SLCO1B7 READTHROUGH TRANSCRIPT PROTEIN-RELATED secondary active transmembrane transporter activity#GO:0015291;carboxylic acid transmembrane transporter activity#GO:0046943;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;active transmembrane transporter activity#GO:0022804;bile acid transmembrane transporter activity#GO:0015125 bile acid and bile salt transport#GO:0015721;carboxylic acid transport#GO:0046942;transport#GO:0006810;organic acid transport#GO:0015849;lipid localization#GO:0010876;organic hydroxy compound transport#GO:0015850;monocarboxylic acid transport#GO:0015718;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;cellular process#GO:0009987;macromolecule localization#GO:0033036;lipid transport#GO:0006869 cell periphery#GO:0071944;basal plasma membrane#GO:0009925;membrane#GO:0016020;basolateral plasma membrane#GO:0016323;basal part of cell#GO:0045178;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590 transporter#PC00227 HUMAN|HGNC=53904|UniProtKB=A0A2R8YFL7 A0A2R8YFL7 OOSP4A PTHR14380:SF11 PLACENTA-SPECIFIC PROTEIN 1 OOCYTE-SECRETED PROTEIN 4A HUMAN|HGNC=6319|UniProtKB=Q9Y496 Q9Y496 KIF3A PTHR24115:SF472 KINESIN-RELATED KINESIN-LIKE PROTEIN KIF3A microtubule binding#GO:0008017;polypeptide conformation or assembly isomerase activity#GO:0120544;hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887;microtubule motor activity#GO:0003777;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;tubulin binding#GO:0015631;macromolecular conformation isomerase activity#GO:0120543;ribonucleoside triphosphate phosphatase activity#GO:0017111;isomerase activity#GO:0016853;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP-dependent activity#GO:0140657;protein binding#GO:0005515;hydrolase activity, acting on acid anhydrides#GO:0016817;cytoskeletal protein binding#GO:0008092;cytoskeletal motor activity#GO:0003774 plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cytoskeleton-dependent intracellular transport#GO:0030705;establishment of localization in cell#GO:0051649;cell projection assembly#GO:0030031;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;axo-dendritic transport#GO:0008088;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;transport along microtubule#GO:0010970;establishment of localization#GO:0051234;transport#GO:0006810;plasma membrane bounded cell projection assembly#GO:0120031;intracellular transport#GO:0046907;cell projection organization#GO:0030030;microtubule-based movement#GO:0007018;cilium assembly#GO:0060271;cellular component organization#GO:0016043;anterograde axonal transport#GO:0008089;cilium organization#GO:0044782;localization#GO:0051179;cellular localization#GO:0051641;microtubule-based transport#GO:0099111;axonal transport#GO:0098930;organelle assembly#GO:0070925 microtubule#GO:0005874;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;microtubule associated complex#GO:0005875;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630 microtubule or microtubule-binding cytoskeletal protein#PC00157;microtubule binding motor protein#PC00156 HUMAN|HGNC=4482|UniProtKB=Q9NS67 Q9NS67 GPR27 PTHR19268:SF8 G PROTEIN-COUPLED RECEPTOR G PROTEIN-COUPLED RECEPTOR 27-RELATED transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=9164|UniProtKB=Q99719 Q99719 SEPTIN5 PTHR18884:SF68 SEPTIN SEPTIN-5 hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides#GO:0016817 regulation of cellular process#GO:0050794;cell cycle#GO:0007049;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;cell cycle process#GO:0022402;cell division#GO:0051301;cytoskeleton-dependent cytokinesis#GO:0061640;localization#GO:0051179;regulation of secretion#GO:0051046;regulation of exocytosis#GO:0017157;regulation of secretion by cell#GO:1903530;cytokinesis#GO:0000910;biological regulation#GO:0065007;macromolecule localization#GO:0033036;cellular process#GO:0009987;regulation of transport#GO:0051049;regulation of localization#GO:0032879;intracellular protein localization#GO:0008104 intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;synaptic vesicle#GO:0008021;vesicle#GO:0031982;cell cortex#GO:0005938;intracellular vesicle#GO:0097708;membraneless organelle#GO:0043228;cell junction#GO:0030054;cytoskeleton#GO:0005856;cytoplasm#GO:0005737;cell division site#GO:0032153;intracellular membraneless organelle#GO:0043232;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;transport vesicle#GO:0030133;cell periphery#GO:0071944;presynapse#GO:0098793;secretory vesicle#GO:0099503;microtubule cytoskeleton#GO:0015630 cytoskeletal protein#PC00085 Parkinson disease#P00049>CDCrel-1#P01226 HUMAN|HGNC=18085|UniProtKB=Q8N511 Q8N511 VMA12 PTHR31394:SF1 TRANSMEMBRANE PROTEIN 199 VACUOLAR ATPASE ASSEMBLY PROTEIN VMA12 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 HUMAN|HGNC=21023|UniProtKB=Q9GZM5 Q9GZM5 YIPF3 PTHR15627:SF14 NATURAL KILLER CELL-SPECIFIC ANTIGEN KLIP1 PROTEIN YIPF3 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794 HUMAN|HGNC=21484|UniProtKB=Q9NXL9 Q9NXL9 MCM9 PTHR11630:SF48 DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER DNA HELICASE MCM9 double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;DNA recombination#GO:0006310;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;response to stress#GO:0006950;cellular response to stress#GO:0033554;recombinational repair#GO:0000725;response to stimulus#GO:0050896;double-strand break repair via homologous recombination#GO:0000724;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 DNA metabolism protein#PC00009 HUMAN|HGNC=12540|UniProtKB=Q9HAW9 Q9HAW9 UGT1A8 PTHR48050:SF6 STEROL 3-BETA-GLUCOSYLTRANSFERASE UDP-GLUCURONOSYLTRANSFERASE 1A10-RELATED molecular function inhibitor activity#GO:0140678;protein binding#GO:0005515;enzyme regulator activity#GO:0030234;enzyme binding#GO:0019899;binding#GO:0005488;molecular function regulator activity#GO:0098772;glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194;enzyme inhibitor activity#GO:0004857;transferase activity#GO:0016740;catalytic activity#GO:0003824 primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;anatomical structure development#GO:0048856;system development#GO:0048731;response to steroid hormone#GO:0048545;hormone metabolic process#GO:0042445;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;pigment metabolic process#GO:0042440;sterol metabolic process#GO:0016125;developmental process#GO:0032502;lipid metabolic process#GO:0006629;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;cellular response to hormone stimulus#GO:0032870;liver development#GO:0001889;response to endogenous stimulus#GO:0009719;regulation of hormone levels#GO:0010817;estrogen metabolic process#GO:0008210;regulation of biological quality#GO:0065008;cellular response to chemical stimulus#GO:0070887;animal gross anatomical part developmental process#GO:0160108;response to chemical#GO:0042221;response to lipid#GO:0033993;cellular response to lipid#GO:0071396;steroid metabolic process#GO:0008202;response to hormone#GO:0009725;cellular process#GO:0009987;multicellular organism development#GO:0007275;animal organ development#GO:0048513;cellular response to steroid hormone stimulus#GO:0071383;metabolic process#GO:0008152 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111;transferase#PC00220 HUMAN|HGNC=15939|UniProtKB=Q14508 Q14508 WFDC2 PTHR19441:SF34 WAP four-disulfide core domain protein WAP FOUR-DISULFIDE CORE DOMAIN PROTEIN 2 peptidase regulator activity#GO:0061134;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;serine-type endopeptidase inhibitor activity#GO:0004867;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;enzyme inhibitor activity#GO:0004857;molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866 response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;defense response to bacterium#GO:0042742;immune system process#GO:0002376;response to bacterium#GO:0009617;response to other organism#GO:0051707;defense response to other organism#GO:0098542;defense response to symbiont#GO:0140546;immune response#GO:0006955;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;response to external stimulus#GO:0009605;defense response#GO:0006952;innate immune response#GO:0045087;antibacterial humoral response#GO:0019731;antimicrobial humoral response#GO:0019730;humoral immune response#GO:0006959 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HUMAN|HGNC=7710|UniProtKB=O75489 O75489 NDUFS3 PTHR10884:SF15 NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 3 NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 3, MITOCHONDRIAL transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;respiratory chain complex I#GO:0045271;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;respiratory chain complex#GO:0098803;oxidoreductase complex#GO:1990204;membrane#GO:0016020;membrane protein complex#GO:0098796 dehydrogenase#PC00092;oxidoreductase#PC00176 HUMAN|HGNC=13593|UniProtKB=Q8NEZ5 Q8NEZ5 FBXO22 PTHR14939:SF10 F-BOX ONLY PROTEIN 22 F-BOX ONLY PROTEIN 22 ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;regulation of cell differentiation#GO:0045595;biological regulation#GO:0065007;proteasomal protein catabolic process#GO:0010498;cellular process#GO:0009987;regulation of cell development#GO:0060284;protein metabolic process#GO:0019538;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;regulation of developmental process#GO:0050793;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;modification-dependent protein catabolic process#GO:0019941 protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535;SCF ubiquitin ligase complex#GO:0019005;transferase complex#GO:1990234;catalytic complex#GO:1902494 HUMAN|HGNC=37179|UniProtKB=Q6QN14 Q6QN14 USP17L6P PTHR24006:SF651 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE INACTIVE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 17-LIKE PROTEIN 4-RELATED catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;cysteine-type deubiquitinase activity#GO:0004843;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005 regulation of programmed cell death#GO:0043067;regulation of apoptotic process#GO:0042981;regulation of biological process#GO:0050789;regulation of protein stability#GO:0031647;regulation of cellular process#GO:0050794;regulation of biological quality#GO:0065008;biological regulation#GO:0065007 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cytosol#GO:0005829;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 protease#PC00190;cysteine protease#PC00081 HUMAN|HGNC=19172|UniProtKB=Q8IZ96 Q8IZ96 CMTM1 PTHR22776:SF43 MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN CKLF-LIKE MARVEL TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 1 response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;immune system process#GO:0002376;regulation of biological process#GO:0050789;immune response#GO:0006955 cellular anatomical structure#GO:0110165;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HUMAN|HGNC=26599|UniProtKB=Q8IWD4 Q8IWD4 CCDC117 PTHR36128:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 117 COILED-COIL DOMAIN-CONTAINING PROTEIN 117 HUMAN|HGNC=11067|UniProtKB=P82251 P82251 SLC7A9 PTHR11785:SF354 AMINO ACID TRANSPORTER B(0,+)-TYPE AMINO ACID TRANSPORTER 1 L-amino acid transmembrane transporter activity#GO:0015179;neutral L-amino acid transmembrane transporter activity#GO:0015175;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;carboxylic acid transmembrane transporter activity#GO:0046943;amino acid transmembrane transporter activity#GO:0015171 transport#GO:0006810;carboxylic acid transport#GO:0046942;amino acid transport#GO:0006865;organic acid transport#GO:0015849;amino acid transmembrane transport#GO:0003333;establishment of localization#GO:0051234;neutral amino acid transport#GO:0015804;transmembrane transport#GO:0055085;localization#GO:0051179;nitrogen compound transport#GO:0071705;L-amino acid transport#GO:0015807;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227 HUMAN|HGNC=25905|UniProtKB=Q96EX2 Q96EX2 RNFT2 PTHR15860:SF2 UNCHARACTERIZED RING FINGER-CONTAINING PROTEIN E3 UBIQUITIN-PROTEIN LIGASE RNFT2 aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746 HUMAN|HGNC=11405|UniProtKB=Q8IWQ3 Q8IWQ3 BRSK2 PTHR24343:SF84 SERINE/THREONINE KINASE SERINE_THREONINE-PROTEIN KINASE BRSK2 phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 cell projection morphogenesis#GO:0048858;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;cell cycle G2/M phase transition#GO:0044839;cellular process#GO:0009987;neuron projection development#GO:0031175;neuron development#GO:0048666;axonogenesis#GO:0007409;generation of neurons#GO:0048699;establishment or maintenance of cell polarity#GO:0007163;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell morphogenesis#GO:0000902;anatomical structure morphogenesis#GO:0009653;cell cycle process#GO:0022402;cellular component organization#GO:0016043;mitotic cell cycle process#GO:1903047;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;plasma membrane bounded cell projection organization#GO:0120036;multicellular organismal process#GO:0032501;axon development#GO:0061564;system development#GO:0048731;anatomical structure development#GO:0048856;mitotic cell cycle phase transition#GO:0044772;mitotic cell cycle#GO:0000278;cell cycle phase transition#GO:0044770;G2/M transition of mitotic cell cycle#GO:0000086;establishment of cell polarity#GO:0030010;cell cycle#GO:0007049 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;centrosome#GO:0005813;microtubule organizing center#GO:0005815;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=20345|UniProtKB=A8K0R7 A8K0R7 ZNF839 PTHR16116:SF5 ZINC FINGER PROTEIN 839 ZINC FINGER PROTEIN 839 HUMAN|HGNC=11725|UniProtKB=Q9UIF3 Q9UIF3 TEKT2 PTHR19960:SF29 TEKTIN TEKTIN-2 cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;organelle assembly#GO:0070925;cilium organization#GO:0044782;cilium-dependent cell motility#GO:0060285;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cell motility#GO:0048870;microtubule-based movement#GO:0007018;cell projection organization#GO:0030030;plasma membrane bounded cell projection assembly#GO:0120031;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cell projection assembly#GO:0030031;cilium movement involved in cell motility#GO:0060294;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226 microtubule or microtubule-binding cytoskeletal protein#PC00157;non-motor microtubule binding protein#PC00166 HUMAN|HGNC=4132|UniProtKB=P47211 P47211 GALR1 PTHR24230:SF31 G-PROTEIN COUPLED RECEPTOR GALANIN RECEPTOR TYPE 1 molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;neuropeptide receptor activity#GO:0008188;transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528 neuropeptide signaling pathway#GO:0007218;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021 HUMAN|HGNC=5992|UniProtKB=P01584 P01584 IL1B PTHR10078:SF30 INTERLEUKIN-1 FAMILY MEMBER INTERLEUKIN-1 BETA molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;cytokine activity#GO:0005125 regulation of signaling#GO:0023051;cellular response to chemical stimulus#GO:0070887;immune system process#GO:0002376;response to stimulus#GO:0050896;positive regulation of multicellular organismal process#GO:0051240;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;response to molecule of bacterial origin#GO:0002237;response to lipopolysaccharide#GO:0032496;positive regulation of mononuclear cell proliferation#GO:0032946;regulation of leukocyte proliferation#GO:0070663;cellular response to lipid#GO:0071396;regulation of ERK1 and ERK2 cascade#GO:0070372;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular response to oxygen-containing compound#GO:1901701;positive regulation of immune system process#GO:0002684;regulation of mononuclear cell proliferation#GO:0032944;response to biotic stimulus#GO:0009607;positive regulation of lymphocyte activation#GO:0051251;regulation of cell population proliferation#GO:0042127;cytokine-mediated signaling pathway#GO:0019221;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of cell-cell adhesion#GO:0022407;regulation of T cell proliferation#GO:0042129;cellular response to stimulus#GO:0051716;cellular response to biotic stimulus#GO:0071216;positive regulation of signal transduction#GO:0009967;defense response#GO:0006952;regulation of response to stimulus#GO:0048583;positive regulation of leukocyte proliferation#GO:0070665;positive regulation of cell activation#GO:0050867;positive regulation of leukocyte cell-cell adhesion#GO:1903039;biological regulation#GO:0065007;regulation of lymphocyte proliferation#GO:0050670;regulation of cell adhesion#GO:0030155;positive regulation of response to stimulus#GO:0048584;regulation of canonical NF-kappaB signal transduction#GO:0043122;immune response#GO:0006955;positive regulation of cellular process#GO:0048522;response to peptide#GO:1901652;positive regulation of signaling#GO:0023056;response to oxygen-containing compound#GO:1901700;regulation of intracellular signal transduction#GO:1902531;regulation of lymphocyte activation#GO:0051249;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;positive regulation of T cell proliferation#GO:0042102;regulation of cell activation#GO:0050865;regulation of leukocyte activation#GO:0002694;positive regulation of cell population proliferation#GO:0008284;positive regulation of canonical NF-kappaB signal transduction#GO:0043123;positive regulation of leukocyte activation#GO:0002696;cell surface receptor signaling pathway#GO:0007166;regulation of MAPK cascade#GO:0043408;regulation of multicellular organismal process#GO:0051239;regulation of T cell activation#GO:0050863;response to lipid#GO:0033993;positive regulation of T cell activation#GO:0050870;response to chemical#GO:0042221;response to cytokine#GO:0034097;cellular response to lipopolysaccharide#GO:0071222;response to stress#GO:0006950;positive regulation of cell-cell adhesion#GO:0022409;cell communication#GO:0007154;inflammatory response#GO:0006954;positive regulation of lymphocyte proliferation#GO:0050671;response to bacterium#GO:0009617;response to external biotic stimulus#GO:0043207;positive regulation of cell communication#GO:0010647;positive regulation of cell adhesion#GO:0045785;response to external stimulus#GO:0009605;cellular response to molecule of bacterial origin#GO:0071219;positive regulation of intracellular signal transduction#GO:1902533;regulation of leukocyte cell-cell adhesion#GO:1903037;response to other organism#GO:0051707;regulation of signal transduction#GO:0009966 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 interleukin superfamily#PC00128;cytokine#PC00083;intercellular signal molecule#PC00207 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>IL2#P00870 HUMAN|HGNC=23718|UniProtKB=Q8TBZ5 Q8TBZ5 ZNF502 PTHR24384:SF253 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED ZINC FINGER PROTEIN 502 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218 HUMAN|HGNC=16652|UniProtKB=Q9HD33 Q9HD33 MRPL47 PTHR21183:SF18 RIBOSOMAL PROTEIN L47, MITOCHONDRIAL-RELATED LARGE RIBOSOMAL SUBUNIT PROTEIN UL29M structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;mitochondrial translation#GO:0032543;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;translation#GO:0006412;metabolic process#GO:0008152;mitochondrial gene expression#GO:0140053;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 organelle lumen#GO:0043233;mitochondrion#GO:0005739;ribosome#GO:0005840;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;large ribosomal subunit#GO:0015934;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;mitochondrial ribosome#GO:0005761;intracellular anatomical structure#GO:0005622;organellar ribosome#GO:0000313;membrane-enclosed lumen#GO:0031974;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;mitochondrial large ribosomal subunit#GO:0005762;membraneless organelle#GO:0043228 ribosomal protein#PC00202;translational protein#PC00263 HUMAN|HGNC=10253|UniProtKB=O95758 O95758 PTBP3 PTHR15592:SF17 MATRIN 3/NUCLEAR PROTEIN 220-RELATED POLYPYRIMIDINE TRACT-BINDING PROTEIN 3 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729 regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA splicing#GO:0043484;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 RNA processing factor#PC00147 HUMAN|HGNC=24102|UniProtKB=Q96EG1 Q96EG1 ARSG PTHR42693:SF42 ARYLSULFATASE FAMILY MEMBER ARYLSULFATASE G hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;hydrolase activity#GO:0016787 hydrolase#PC00121 HUMAN|HGNC=1722|UniProtKB=P06493 P06493 CDK1 PTHR24056:SF334 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE 1 cyclin-dependent protein kinase activity#GO:0097472;protein serine/threonine kinase activity#GO:0004674;cyclin-dependent protein serine/threonine kinase activity#GO:0004693;phosphotransferase activity, alcohol group as acceptor#GO:0016773;histone modifying activity#GO:0140993;protein kinase activity#GO:0004672;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;histone kinase activity#GO:0035173 cellular response to stress#GO:0033554;regulation of mitotic cell cycle phase transition#GO:1901990;negative regulation of mitotic cell cycle#GO:0045930;mitotic G2 DNA damage checkpoint signaling#GO:0007095;negative regulation of biological process#GO:0048519;negative regulation of cell cycle phase transition#GO:1901988;signal transduction in response to DNA damage#GO:0042770;regulation of biological process#GO:0050789;cell cycle process#GO:0022402;response to stimulus#GO:0050896;signaling#GO:0023052;regulation of cell cycle#GO:0051726;negative regulation of cell cycle#GO:0045786;negative regulation of cell cycle G2/M phase transition#GO:1902750;response to stress#GO:0006950;cell cycle G2/M phase transition#GO:0044839;signal transduction#GO:0007165;cellular process#GO:0009987;negative regulation of mitotic cell cycle phase transition#GO:1901991;cell cycle checkpoint signaling#GO:0000075;negative regulation of G2/M transition of mitotic cell cycle#GO:0010972;regulation of cell cycle process#GO:0010564;mitotic cell cycle phase transition#GO:0044772;cell communication#GO:0007154;regulation of G2/M transition of mitotic cell cycle#GO:0010389;intracellular signal transduction#GO:0035556;regulation of cell cycle phase transition#GO:1901987;cell cycle#GO:0007049;mitotic cell cycle checkpoint signaling#GO:0007093;mitotic DNA damage checkpoint signaling#GO:0044773;cellular response to stimulus#GO:0051716;mitotic cell cycle#GO:0000278;regulation of cellular process#GO:0050794;G2/M transition of mitotic cell cycle#GO:0000086;cell cycle phase transition#GO:0044770;negative regulation of cellular process#GO:0048523;DNA damage response#GO:0006974;negative regulation of cell cycle process#GO:0010948;mitotic cell cycle process#GO:1903047;regulation of cell cycle G2/M phase transition#GO:1902749;DNA integrity checkpoint signaling#GO:0031570;mitotic G2/M transition checkpoint#GO:0044818;regulation of mitotic cell cycle#GO:0007346;mitotic DNA integrity checkpoint signaling#GO:0044774;DNA damage checkpoint signaling#GO:0000077;biological regulation#GO:0065007 serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;protein kinase complex#GO:1902911;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 p53 pathway#P00059>Cdc2#P04634 HUMAN|HGNC=21381|UniProtKB=Q7Z6J8 Q7Z6J8 UBE3D PTHR31531:SF2 E3 UBIQUITIN-PROTEIN LIGASE E3D FAMILY MEMBER E3 UBIQUITIN-PROTEIN LIGASE E3D ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;enzyme binding#GO:0019899;acyltransferase activity#GO:0016746;binding#GO:0005488;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;protein binding#GO:0005515;cyclin binding#GO:0030332;transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;protein modification by small protein conjugation or removal#GO:0070647;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;catabolic process#GO:0009056;primary metabolic process#GO:0044238;protein modification process#GO:0036211;modification-dependent protein catabolic process#GO:0019941;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein ubiquitination#GO:0016567;proteasomal protein catabolic process#GO:0010498;post-translational protein modification#GO:0043687;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle#GO:0043229 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=20764|UniProtKB=Q96S99 Q96S99 PLEKHF1 PTHR46280:SF2 PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY F MEMBER 2-RELATED PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY F MEMBER 1 phosphatidylinositol binding#GO:0035091;binding#GO:0005488;anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167 vesicle organization#GO:0016050;endosome organization#GO:0007032;regulation of catabolic process#GO:0009894;positive regulation of catabolic process#GO:0009896;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;transport#GO:0006810;vacuolar transport#GO:0007034;intracellular transport#GO:0046907;biological regulation#GO:0065007;endomembrane system organization#GO:0010256;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;organelle organization#GO:0006996;positive regulation of autophagy#GO:0010508;cellular localization#GO:0051641;localization#GO:0051179;positive regulation of metabolic process#GO:0009893;endosome to lysosome transport#GO:0008333;lysosomal transport#GO:0007041;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;regulation of autophagy#GO:0010506 intracellular vesicle#GO:0097708;vesicle#GO:0031982;lysosome#GO:0005764;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;early endosome#GO:0005769;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;endomembrane system#GO:0012505;vacuole#GO:0005773;cytoplasm#GO:0005737;lytic vacuole#GO:0000323 HUMAN|HGNC=12927|UniProtKB=P52746 P52746 ZNF142 PTHR24409:SF298 ZINC FINGER PROTEIN 142 ZINC FINGER PROTEIN 142 DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=23712|UniProtKB=Q8NBB4 Q8NBB4 ZSCAN1 PTHR23226:SF332 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 1 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=18403|UniProtKB=Q8IZU1 Q8IZU1 FAM9A PTHR19368:SF16 XLR/SCP3/FAM9 PROTEIN FAM9A meiotic cell cycle#GO:0051321;spermatogenesis#GO:0007283;developmental process#GO:0032502;cellular developmental process#GO:0048869;cellular process#GO:0009987;male gamete generation#GO:0048232;spermatid differentiation#GO:0048515;spermatid development#GO:0007286;sexual reproduction#GO:0019953;anatomical structure development#GO:0048856;multicellular organismal reproductive process#GO:0048609;developmental process involved in reproduction#GO:0003006;cell cycle#GO:0007049;germ cell development#GO:0007281;gamete generation#GO:0007276;cell differentiation#GO:0030154;cell development#GO:0048468;reproductive process#GO:0022414;cellular process involved in reproduction in multicellular organism#GO:0022412 nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;synaptonemal structure#GO:0099086;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;synaptonemal complex#GO:0000795;condensed nuclear chromosome#GO:0000794;membraneless organelle#GO:0043228;condensed chromosome#GO:0000793;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 HUMAN|HGNC=12152|UniProtKB=A0A075B6U6 A0A075B6U6 TRAV8-7 PTHR19367:SF9 T-CELL RECEPTOR ALPHA CHAIN V REGION IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN adaptive immune response#GO:0002250;response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 protein-containing complex#GO:0032991 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=30057|UniProtKB=O14626 O14626 GPR171 PTHR24233:SF4 P2Y PURINOCEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR G PROTEIN-COUPLED RECEPTOR 171 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930 biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=29674|UniProtKB=O75452 O75452 RDH16 PTHR43313:SF11 SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C RETINOL DEHYDROGENASE 16 oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;alcohol dehydrogenase (NAD+) activity#GO:0004022;all-trans-retinol dehydrogenase (NAD+) activity#GO:0004745;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824 retinoid metabolic process#GO:0001523;diterpenoid metabolic process#GO:0016101;alcohol metabolic process#GO:0006066;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;hormone metabolic process#GO:0042445;biological regulation#GO:0065007;cellular process#GO:0009987;isoprenoid metabolic process#GO:0006720;regulation of biological quality#GO:0065008;olefinic compound metabolic process#GO:0120254;retinol metabolic process#GO:0042572;terpenoid metabolic process#GO:0006721;small molecule metabolic process#GO:0044281;primary metabolic process#GO:0044238;regulation of hormone levels#GO:0010817 metabolite interconversion enzyme#PC00262;dehydrogenase#PC00092 HUMAN|HGNC=13057|UniProtKB=O43296 O43296 ZNF264 PTHR24377:SF814 IP01015P-RELATED ZINC FINGER PROTEIN 264 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=19087|UniProtKB=Q9H4W6 Q9H4W6 EBF3 PTHR10747:SF4 TRANSCRIPTION FACTOR COE FAMILY MEMBER TRANSCRIPTION FACTOR COE3 DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 P53-like transcription factor#PC00253;DNA-binding transcription factor#PC00218 HUMAN|HGNC=23064|UniProtKB=Q9H4Y5 Q9H4Y5 GSTO2 PTHR43968:SF4 FAMILY NOT NAMED GLUTATHIONE S-TRANSFERASE OMEGA-2 oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;glutathione transferase activity#GO:0004364;antioxidant activity#GO:0016209;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;oxidoreductase activity#GO:0016491;disulfide oxidoreductase activity#GO:0015036 oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;glutathione metabolic process#GO:0006749;monosaccharide metabolic process#GO:0005996;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;modified amino acid metabolic process#GO:0006575;sulfur compound metabolic process#GO:0006790;L-ascorbic acid metabolic process#GO:0019852;cellular process#GO:0009987;small molecule metabolic process#GO:0044281;carbohydrate metabolic process#GO:0005975 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=10614|UniProtKB=O15467 O15467 CCL16 PTHR12015:SF21 SMALL INDUCIBLE CYTOKINE A C-C MOTIF CHEMOKINE 16 cytokine#PC00083 HUMAN|HGNC=21480|UniProtKB=Q9BVJ7 Q9BVJ7 DUSP23 PTHR23339:SF26 TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE DUAL SPECIFICITY PROTEIN PHOSPHATASE 23 catalytic activity#GO:0003824;protein tyrosine/serine/threonine phosphatase activity#GO:0008138;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721 cilium organization#GO:0044782;cellular component organization or biogenesis#GO:0071840;organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cell projection organization#GO:0030030;cellular process#GO:0009987;cell projection assembly#GO:0030031;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HUMAN|HGNC=15630|UniProtKB=O14776 O14776 TCERG1 PTHR15377:SF7 TRANSCRIPTION ELONGATION REGULATOR 1 TRANSCRIPTION ELONGATION REGULATOR 1 protein binding#GO:0005515;transcription coregulator activity#GO:0003712;binding#GO:0005488;RNA polymerase binding#GO:0070063;enzyme binding#GO:0019899;transcription regulator activity#GO:0140110 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 general transcription factor#PC00259 HUMAN|HGNC=20351|UniProtKB=Q96DC9 Q96DC9 OTUB2 PTHR12931:SF3 UBIQUITIN THIOLESTERASE PROTEIN OTUB UBIQUITIN THIOESTERASE OTUB2 binding#GO:0005488;deubiquitinase activity#GO:0101005;protein binding#GO:0005515;hydrolase activity#GO:0016787;cysteine-type deubiquitinase activity#GO:0004843;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;ubiquitin binding#GO:0043130;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783 protease#PC00190;protein modifying enzyme#PC00260;cysteine protease#PC00081 HUMAN|HGNC=6896|UniProtKB=Q9P0L2 Q9P0L2 MARK1 PTHR24346:SF21 MAP/MICROTUBULE AFFINITY-REGULATING KINASE SERINE_THREONINE-PROTEIN KINASE MARK1 phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;intracellular signal transduction#GO:0035556;microtubule cytoskeleton organization#GO:0000226;cell communication#GO:0007154;cellular process#GO:0009987;signal transduction#GO:0007165;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=9071|UniProtKB=P00747 P00747 PLG PTHR24261:SF13 PLASMINOGEN-RELATED PLASMINOGEN protein binding#GO:0005515;hydrolase activity#GO:0016787;binding#GO:0005488;signaling receptor binding#GO:0005102;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 negative regulation of coagulation#GO:0050819;protein metabolic process#GO:0019538;regulation of biological quality#GO:0065008;proteolysis#GO:0006508;negative regulation of hemostasis#GO:1900047;regulation of blood coagulation#GO:0030193;regulation of body fluid levels#GO:0050878;regulation of wound healing#GO:0061041;negative regulation of multicellular organismal process#GO:0051241;negative regulation of biological process#GO:0048519;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;macromolecule metabolic process#GO:0043170;negative regulation of response to wounding#GO:1903035;metabolic process#GO:0008152;negative regulation of blood coagulation#GO:0030195;regulation of response to stress#GO:0080134;regulation of response to stimulus#GO:0048583;fibrinolysis#GO:0042730;regulation of coagulation#GO:0050818;negative regulation of response to stimulus#GO:0048585;regulation of response to external stimulus#GO:0032101;negative regulation of response to external stimulus#GO:0032102;biological regulation#GO:0065007;regulation of multicellular organismal process#GO:0051239;regulation of response to wounding#GO:1903034;negative regulation of wound healing#GO:0061045;regulation of hemostasis#GO:1900046;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 serine protease#PC00203;protein modifying enzyme#PC00260 Blood coagulation#P00011>Plasmin#P00415;Blood coagulation#P00011>Plasminogen#P00408;Plasminogen activating cascade#P00050>Plasminogen#P01255;Plasminogen activating cascade#P00050>Plasmin#P01246 HUMAN|HGNC=10774|UniProtKB=P23246 P23246 SFPQ PTHR23189:SF51 RNA RECOGNITION MOTIF-CONTAINING SPLICING FACTOR, PROLINE- AND GLUTAMINE-RICH RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA splicing, via transesterification reactions#GO:0000375;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulation of RNA biosynthetic process#GO:2001141;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;macromolecule biosynthetic process#GO:0009059;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;mRNA metabolic process#GO:0016071;mRNA splicing, via spliceosome#GO:0000398;regulation of biological process#GO:0050789;alternative mRNA splicing, via spliceosome#GO:0000380;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;mRNA processing#GO:0006397 RNA metabolism protein#PC00031 HUMAN|HGNC=26195|UniProtKB=Q86XH1 Q86XH1 DRC11 PTHR14690:SF8 IQ MOTIF CONTAINING WITH AAA DOMAIN 1 DYNEIN REGULATORY COMPLEX SUBUNIT 11 HUMAN|HGNC=7607|UniProtKB=Q6PIF6 Q6PIF6 MYO7B PTHR13140:SF505 MYOSIN UNCONVENTIONAL MYOSIN-VIIB isomerase activity#GO:0016853;cytoskeletal motor activity#GO:0003774;ATP-dependent activity#GO:0140657;macromolecular conformation isomerase activity#GO:0120543;microfilament motor activity#GO:0000146;polypeptide conformation or assembly isomerase activity#GO:0120544;catalytic activity#GO:0003824 cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;sensory perception of sound#GO:0007605;animal gross anatomical part developmental process#GO:0160108;actin filament-based process#GO:0030029;nervous system process#GO:0050877;sensory perception#GO:0007600;sensory perception of mechanical stimulus#GO:0050954;anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;organelle organization#GO:0006996;actin filament-based movement#GO:0030048;cellular process#GO:0009987;multicellular organismal process#GO:0032501;cytoskeleton organization#GO:0007010;sensory organ development#GO:0007423;developmental process#GO:0032502;animal organ development#GO:0048513;cellular component organization or biogenesis#GO:0071840;system process#GO:0003008;actin filament organization#GO:0007015 membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;apical part of cell#GO:0045177;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;membrane#GO:0016020;brush border#GO:0005903;cluster of actin-based cell projections#GO:0098862;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;actin cytoskeleton#GO:0015629;microvillus#GO:0005902;actin-based cell projection#GO:0098858 actin binding motor protein#PC00040 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HUMAN|HGNC=1184|UniProtKB=Q9NQ89 Q9NQ89 FERRY3 PTHR16525:SF0 PROTEIN C12ORF4 FERRY ENDOSOMAL RAB5 EFFECTOR COMPLEX SUBUNIT 3 biological regulation#GO:0065007;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of leukocyte mediated immunity#GO:0002703;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;regulation of localization#GO:0032879;regulation of transport#GO:0051049;regulation of secretion by cell#GO:1903530;regulation of exocytosis#GO:0017157;regulation of secretion#GO:0051046;regulation of immune effector process#GO:0002697 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=9997|UniProtKB=O15492 O15492 RGS16 PTHR10845:SF187 REGULATOR OF G PROTEIN SIGNALING REGULATOR OF G PROTEIN SIGNALING 16 molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;enzyme activator activity#GO:0008047 regulation of G protein-coupled receptor signaling pathway#GO:0008277;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648;regulation of biological process#GO:0050789;negative regulation of G protein-coupled receptor signaling pathway#GO:0045744;negative regulation of biological process#GO:0048519;negative regulation of signal transduction#GO:0009968;regulation of cell communication#GO:0010646;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cellular process#GO:0050794;negative regulation of response to stimulus#GO:0048585 membrane#GO:0016020;cytoplasmic side of plasma membrane#GO:0009898;cell periphery#GO:0071944;cytoplasmic side of membrane#GO:0098562;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 GTPase-activating protein#PC00257 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>RGS#P00704;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>RGS#P00731 HUMAN|HGNC=21729|UniProtKB=Q7Z5L9 Q7Z5L9 IRF2BP2 PTHR10816:SF18 MYELIN TRANSCRIPTION FACTOR 1-RELATED INTERFERON REGULATORY FACTOR 2-BINDING PROTEIN 2 transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;zinc finger transcription factor#PC00244 HUMAN|HGNC=30236|UniProtKB=O14804 O14804 TAAR5 PTHR24249:SF307 HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR TRACE AMINE-ASSOCIATED RECEPTOR 5 signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021 HUMAN|HGNC=18394|UniProtKB=Q8TD33 Q8TD33 SCGB1C1 PTHR10136:SF8 SECRETOGLOBIN FAMILY 1 MEMBER SECRETOGLOBIN FAMILY 1C MEMBER 1-RELATED cytokine#PC00083 HUMAN|HGNC=25188|UniProtKB=Q5JUR7 Q5JUR7 TEX30 PTHR13136:SF11 TESTIS DEVELOPMENT PROTEIN PRTD TESTIS-EXPRESSED PROTEIN 30 HUMAN|HGNC=19735|UniProtKB=Q7L775 Q7L775 EPM2AIP1 PTHR45913:SF11 EPM2A-INTERACTING PROTEIN 1 EPM2A-INTERACTING PROTEIN 1 positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of carbohydrate biosynthetic process#GO:0043255;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of polysaccharide biosynthetic process#GO:0032885;regulation of biosynthetic process#GO:0009889;regulation of glycogen biosynthetic process#GO:0005979;regulation of carbohydrate metabolic process#GO:0006109;regulation of polysaccharide metabolic process#GO:0032881;biological regulation#GO:0065007;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 HUMAN|HGNC=11125|UniProtKB=P61956 P61956 SUMO2 PTHR10562:SF131 SMALL UBIQUITIN-RELATED MODIFIER SMALL UBIQUITIN-RELATED MODIFIER 2-RELATED enzyme binding#GO:0019899;ubiquitin-like protein ligase binding#GO:0044389;binding#GO:0005488;protein binding#GO:0005515 protein modification process#GO:0036211;primary metabolic process#GO:0044238;protein modification by small protein conjugation#GO:0032446;cellular process#GO:0009987;post-translational protein modification#GO:0043687;metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647;macromolecule metabolic process#GO:0043170;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein sumoylation#GO:0016925 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 p53 pathway#P00059>Sumo-1 ligase#P04635 HUMAN|HGNC=9676|UniProtKB=Q16849 Q16849 PTPRN PTHR46106:SF1 IA-2 PROTEIN TYROSINE PHOSPHATASE, ISOFORM C RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE-LIKE N transport#GO:0006810;establishment of protein localization to extracellular region#GO:0035592;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;nitrogen compound transport#GO:0071705;peptide transport#GO:0015833;macromolecule localization#GO:0033036;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;response to glucose#GO:0009749;insulin secretion#GO:0030073;peptide secretion#GO:0002790;signal release#GO:0023061;peptide hormone secretion#GO:0030072;secretion#GO:0046903;cell communication#GO:0007154;regulation of secretion#GO:0051046;localization#GO:0051179;protein localization to extracellular region#GO:0071692;cellular response to stimulus#GO:0051716;homeostatic process#GO:0042592;hormone transport#GO:0009914;chemical homeostasis#GO:0048878;cellular response to glucose stimulus#GO:0071333;glucose homeostasis#GO:0042593;regulation of transport#GO:0051049;regulation of localization#GO:0032879;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;cellular response to oxygen-containing compound#GO:1901701;establishment of protein localization#GO:0045184;response to chemical#GO:0042221;response to oxygen-containing compound#GO:1901700;response to monosaccharide#GO:0034284;cellular response to chemical stimulus#GO:0070887;regulation of biological quality#GO:0065008;protein transport#GO:0015031;hormone secretion#GO:0046879;intracellular glucose homeostasis#GO:0001678;secretion by cell#GO:0032940;response to carbohydrate#GO:0009743;cellular localization#GO:0051641;protein secretion#GO:0009306;carbohydrate homeostasis#GO:0033500;regulation of hormone levels#GO:0010817;regulation of biological process#GO:0050789;response to hexose#GO:0009746;export from cell#GO:0140352;signaling#GO:0023052;response to stimulus#GO:0050896 vesicle#GO:0031982;secretory vesicle#GO:0099503;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;cell junction#GO:0030054 protein phosphatase#PC00195 HUMAN|HGNC=20651|UniProtKB=Q8NCC5 Q8NCC5 SLC37A3 PTHR43184:SF33 MAJOR FACILITATOR SUPERFAMILY TRANSPORTER 16, ISOFORM B SUGAR PHOSPHATE EXCHANGER 3 xenobiotic transmembrane transporter activity#GO:0042910;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984 transporter#PC00227 HUMAN|HGNC=14201|UniProtKB=Q9HDC5 Q9HDC5 JPH1 PTHR23085:SF6 GH28348P JUNCTOPHILIN-1 endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;sarcoplasm#GO:0016528;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;sarcoplasmic reticulum#GO:0016529;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;endomembrane system#GO:0012505;protein-containing complex#GO:0032991 HUMAN|HGNC=34496|UniProtKB=A6NCJ1 A6NCJ1 TEKTIP1 PTHR31254:SF1 HYPOTHETICAL PROTEIN LOC690617 TEKTIN BUNDLE-INTERACTING PROTEIN 1 HUMAN|HGNC=7527|UniProtKB=Q9UIF7 Q9UIF7 MUTYH PTHR42944:SF1 ADENINE DNA GLYCOSYLASE ADENINE DNA GLYCOSYLASE hydrolase activity, acting on glycosyl bonds#GO:0016798;catalytic activity, acting on DNA#GO:0140097;damaged DNA binding#GO:0003684;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;double-stranded DNA binding#GO:0003690;hydrolase activity#GO:0016787;DNA binding#GO:0003677;DNA N-glycosylase activity#GO:0019104;nucleic acid binding#GO:0003676;binding#GO:0005488 nucleobase-containing compound metabolic process#GO:0006139;response to stimulus#GO:0050896;cellular process#GO:0009987;mismatch repair#GO:0006298;cellular response to stimulus#GO:0051716;base-excision repair#GO:0006284;response to stress#GO:0006950;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;cellular response to stress#GO:0033554;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA metabolism protein#PC00009;DNA glycosylase#PC00010 HUMAN|HGNC=25759|UniProtKB=Q49AM3 Q49AM3 TTC31 PTHR47678:SF1 TETRATRICOPEPTIDE REPEAT PROTEIN 31 TETRATRICOPEPTIDE REPEAT PROTEIN 31 HUMAN|HGNC=11695|UniProtKB=Q8IZS6 Q8IZS6 DYNLT2 PTHR21255:SF27 T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN DYNEIN LIGHT CHAIN TCTEX-TYPE PROTEIN 2 protein binding#GO:0005515;binding#GO:0005488 cellular process#GO:0009987;microtubule-based movement#GO:0007018;microtubule-based process#GO:0007017 microtubule cytoskeleton#GO:0015630;cytoplasmic dynein complex#GO:0005868;dynein complex#GO:0030286;organelle#GO:0043226;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=33830|UniProtKB=Q08AG7 Q08AG7 MZT1 PTHR28520:SF15 MITOTIC-SPINDLE ORGANIZING PROTEIN 1 MITOTIC-SPINDLE ORGANIZING PROTEIN 1 organelle assembly#GO:0070925;supramolecular fiber organization#GO:0097435;organelle fission#GO:0048285;microtubule cytoskeleton organization#GO:0000226;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cell cycle#GO:0007049;mitotic cell cycle#GO:0000278;chromosome organization#GO:0051276;microtubule polymerization#GO:0046785;mitotic cell cycle process#GO:1903047;spindle organization#GO:0007051;mitotic spindle assembly#GO:0090307;mitotic sister chromatid segregation#GO:0000070;microtubule polymerization or depolymerization#GO:0031109;nuclear division#GO:0000280;mitotic nuclear division#GO:0140014;cell cycle process#GO:0022402;protein-containing complex assembly#GO:0065003;protein polymerization#GO:0051258;cellular component organization#GO:0016043;sister chromatid segregation#GO:0000819;nuclear chromosome segregation#GO:0098813;membraneless organelle assembly#GO:0140694;microtubule nucleation#GO:0007020;mitotic spindle organization#GO:0007052;chromosome segregation#GO:0007059;microtubule-based process#GO:0007017;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;spindle assembly#GO:0051225;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607 organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;microtubule organizing center#GO:0005815;centrosome#GO:0005813;spindle#GO:0005819;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 HUMAN|HGNC=28026|UniProtKB=Q7Z572 Q7Z572 SPATA21 PTHR47500:SF1 EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN SPERMATOGENESIS-ASSOCIATED PROTEIN 21 calmodulin-related#PC00061;calcium-binding protein#PC00060 HUMAN|HGNC=16153|UniProtKB=Q9NUG4 Q9NUG4 CCM2L PTHR21642:SF2 CEREBRAL CAVERNOUS MALFORMATIONS PROTEIN 2 HOMOLOG CEREBRAL CAVERNOUS MALFORMATIONS 2 PROTEIN-LIKE animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502;multicellular organism development#GO:0007275;anatomical structure development#GO:0048856;animal organ development#GO:0048513;system development#GO:0048731;anatomical structure morphogenesis#GO:0009653;heart morphogenesis#GO:0003007;circulatory system development#GO:0072359;heart development#GO:0007507;multicellular organismal process#GO:0032501;animal organ morphogenesis#GO:0009887 HUMAN|HGNC=40020|UniProtKB=E7ERA6 E7ERA6 RNF223 PTHR22791:SF4 RING-TYPE DOMAIN-CONTAINING PROTEIN RING FINGER PROTEIN 223 ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;protein modification process#GO:0036211;primary metabolic process#GO:0044238;cellular process#GO:0009987;protein modification by small protein conjugation#GO:0032446;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=10888|UniProtKB=Q9NPC8 Q9NPC8 SIX2 PTHR10390:SF77 HOMEOBOX PROTEIN SIX HOMEOBOX PROTEIN SIX2 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690 regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;animal gross anatomical part developmental process#GO:0160108;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;renal system development#GO:0072001;regulation of primary metabolic process#GO:0080090;kidney development#GO:0001822;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;developmental process#GO:0032502;multicellular organism development#GO:0007275;regulation of biosynthetic process#GO:0009889;animal organ development#GO:0048513;regulation of gene expression#GO:0010468 membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 HUMAN|HGNC=2292|UniProtKB=P15954 P15954 COX7C PTHR13313:SF1 CYTOCHROME C OXIDASE SUBUNIT VIIC CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL generation of precursor metabolites and energy#GO:0006091;metabolic process#GO:0008152;aerobic electron transport chain#GO:0019646;mitochondrial electron transport, cytochrome c to oxygen#GO:0006123;aerobic respiration#GO:0009060;ATP synthesis coupled electron transport#GO:0042773;oxidative phosphorylation#GO:0006119;cellular respiration#GO:0045333;energy derivation by oxidation of organic compounds#GO:0015980;mitochondrial ATP synthesis coupled electron transport#GO:0042775;cellular process#GO:0009987;respiratory electron transport chain#GO:0022904;electron transport chain#GO:0022900 protein-containing complex#GO:0032991;cytoplasm#GO:0005737;oxidoreductase complex#GO:1990204;membrane#GO:0016020;respiratory chain complex#GO:0098803;transporter complex#GO:1990351;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;mitochondrion#GO:0005739;cytochrome complex#GO:0070069;respiratory chain complex IV#GO:0045277;transmembrane transporter complex#GO:1902495;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 oxidase#PC00175;oxidoreductase#PC00176 HUMAN|HGNC=241|UniProtKB=P18509 P18509 ADCYAP1 PTHR11213:SF1 GLUCAGON-FAMILY NEUROPEPTIDE PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE neuropeptide hormone activity#GO:0005184;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;protein binding#GO:0005515;hormone activity#GO:0005179;molecular function activator activity#GO:0140677;signaling receptor binding#GO:0005102;binding#GO:0005488;hormone receptor binding#GO:0051427 positive regulation of signal transduction#GO:0009967;neuropeptide signaling pathway#GO:0007218;cellular response to stimulus#GO:0051716;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;positive regulation of ERK1 and ERK2 cascade#GO:0070374;cell communication#GO:0007154;anatomical structure development#GO:0048856;system development#GO:0048731;positive regulation of cellular process#GO:0048522;positive regulation of response to stimulus#GO:0048584;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;plasma membrane bounded cell projection organization#GO:0120036;developmental process#GO:0032502;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;cellular developmental process#GO:0048869;positive regulation of MAPK cascade#GO:0043410;neurogenesis#GO:0022008;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;cell projection organization#GO:0030030;response to stimulus#GO:0050896;cell differentiation#GO:0030154;signaling#GO:0023052;cell development#GO:0048468;G protein-coupled receptor signaling pathway#GO:0007186;regulation of intracellular signal transduction#GO:1902531;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;regulation of protein localization#GO:0032880;neuron development#GO:0048666;neuron projection development#GO:0031175;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of ERK1 and ERK2 cascade#GO:0070372;nervous system development#GO:0007399;regulation of MAPK cascade#GO:0043408;neuron differentiation#GO:0030182;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;regulation of localization#GO:0032879 perikaryon#GO:0043204;cell body#GO:0044297;neuron projection#GO:0043005;cellular anatomical structure#GO:0110165;neuronal cell body#GO:0043025;cell projection#GO:0042995;somatodendritic compartment#GO:0036477;plasma membrane bounded cell projection#GO:0120025 neuropeptide#PC00162 Gonadotropin-releasing hormone receptor pathway#P06664>PACAP#G06667;Gonadotropin-releasing hormone receptor pathway#P06664>PACAP#P06800;Gonadotropin-releasing hormone receptor pathway#P06664>PACAP#G06879 HUMAN|HGNC=1140|UniProtKB=O00478 O00478 BTN3A3 PTHR24100:SF56 BUTYROPHILIN BUTYROPHILIN SUBFAMILY 3 MEMBER A3 protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488 antigen receptor-mediated signaling pathway#GO:0050851;regulation of multicellular organismal process#GO:0051239;positive regulation of immune system process#GO:0002684;activation of immune response#GO:0002253;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;immune response-activating signaling pathway#GO:0002757;cell surface receptor signaling pathway#GO:0007166;response to stimulus#GO:0050896;signaling#GO:0023052;regulation of biological process#GO:0050789;immune response-regulating signaling pathway#GO:0002764;immune system process#GO:0002376;positive regulation of response to stimulus#GO:0048584;immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007;regulation of cytokine production#GO:0001817;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;T cell receptor signaling pathway#GO:0050852;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;regulation of macromolecule metabolic process#GO:0060255;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;immune response-activating cell surface receptor signaling pathway#GO:0002429;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;regulation of immune response#GO:0050776 membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=8939|UniProtKB=Q9UMS5 Q9UMS5 PHTF1 PTHR12680:SF8 PUTATIVE HOMEODOMAIN TRANSCRIPTION FACTOR PHTF PROTEIN PHTF1 homeodomain transcription factor#PC00119 HUMAN|HGNC=24593|UniProtKB=Q9H2H0 Q9H2H0 CXXC4 PTHR13419:SF1 ZINC FINGER-CONTAINING CXXC-TYPE ZINC FINGER PROTEIN 4 heterocyclic compound binding#GO:1901363;nucleotide binding#GO:0000166;sequence-specific DNA binding#GO:0043565;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;nucleic acid binding#GO:0003676;small molecule binding#GO:0036094;DNA binding#GO:0003677 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=6647|UniProtKB=P29536 P29536 LMOD1 PTHR10901:SF5 TROPOMODULIN LEIOMODIN-1 protein binding#GO:0005515;binding#GO:0005488;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092 cellular anatomical entity morphogenesis#GO:0032989;cellular component organization or biogenesis#GO:0071840;striated muscle cell differentiation#GO:0051146;anatomical structure formation involved in morphogenesis#GO:0048646;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;animal gross anatomical part developmental process#GO:0160108;striated muscle cell development#GO:0055002;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;muscle system process#GO:0003012;anatomical structure morphogenesis#GO:0009653;cell differentiation#GO:0030154;actomyosin structure organization#GO:0031032;cell development#GO:0048468;developmental process#GO:0032502;muscle contraction#GO:0006936;cellular developmental process#GO:0048869;actin filament organization#GO:0007015;system process#GO:0003008;multicellular organismal process#GO:0032501;organelle assembly#GO:0070925;cellular component assembly involved in morphogenesis#GO:0010927;actin filament-based process#GO:0030029;anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;muscle cell development#GO:0055001;myofibril assembly#GO:0030239;muscle cell differentiation#GO:0042692;muscle structure development#GO:0061061;actin cytoskeleton organization#GO:0030036 cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;organelle#GO:0043226;supramolecular complex#GO:0099080;contractile muscle fiber#GO:0043292;actin cytoskeleton#GO:0015629;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membraneless organelle#GO:0043228;myofibril#GO:0030016;sarcomere#GO:0030017;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=3239|UniProtKB=P11161 P11161 EGR2 PTHR23235:SF54 KRUEPPEL-LIKE TRANSCRIPTION FACTOR E3 SUMO-PROTEIN LIGASE EGR2 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=17980|UniProtKB=Q96LB0 Q96LB0 MRGPRX3 PTHR11334:SF34 MAS-RELATED G-PROTEIN COUPLED RECEPTOR MAS-RELATED G PROTEIN-COUPLED RECEPTOR MEMBER X3 G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=4462|UniProtKB=Q14956 Q14956 GPNMB PTHR11861:SF11 MELANOCYTE PROTEIN PMEL 17-RELATED TRANSMEMBRANE GLYCOPROTEIN NMB cell adhesion molecule binding#GO:0050839;binding#GO:0005488;signaling receptor binding#GO:0005102;integrin binding#GO:0005178;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 cellular process#GO:0009987;cell adhesion#GO:0007155 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 membrane-bound signaling molecule#PC00152 HUMAN|HGNC=26853|UniProtKB=Q8N7Z5 Q8N7Z5 ANKRD31 PTHR24176:SF14 ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 31-RELATED ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 31 HUMAN|HGNC=28816|UniProtKB=Q7L592 Q7L592 NDUFAF7 PTHR12049:SF7 PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL N-methyltransferase activity#GO:0008170;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;catalytic activity, acting on a protein#GO:0140096;protein methyltransferase activity#GO:0008276;transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;catalytic activity#GO:0003824 cellular component organization or biogenesis#GO:0071840;NADH dehydrogenase complex assembly#GO:0010257;protein-containing complex organization#GO:0043933;cellular component organization#GO:0016043;mitochondrial respiratory chain complex I assembly#GO:0032981;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;cellular component assembly#GO:0022607;mitochondrion organization#GO:0007005;mitochondrial respiratory chain complex assembly#GO:0033108 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HUMAN|HGNC=28536|UniProtKB=Q8IYX1 Q8IYX1 TBC1D21 PTHR22957:SF489 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN TBC1 DOMAIN FAMILY MEMBER 21 enzyme activator activity#GO:0008047;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096 GTPase-activating protein#PC00257;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HUMAN|HGNC=7998|UniProtKB=O14511 O14511 NRG2 PTHR11100:SF20 HEREGULIN-NEUREGULIN FAMILY MEMBER PRO-NEUREGULIN-2, MEMBRANE-BOUND ISOFORM protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;animal gross anatomical part developmental process#GO:0160108;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;ERBB signaling pathway#GO:0038127;cellular process#GO:0009987;signal transduction#GO:0007165;biological regulation#GO:0065007;cell surface receptor signaling pathway#GO:0007166;developmental process#GO:0032502;animal organ development#GO:0048513 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 growth factor#PC00112;intercellular signal molecule#PC00207 EGF receptor signaling pathway#P00018>EGF#P00549 HUMAN|HGNC=23784|UniProtKB=Q9BTC8 Q9BTC8 MTA3 PTHR10865:SF6 METASTASIS-ASSOCIATED PROTEIN AND MESODERM INDUCTION EARLY RESPONSE PROTEIN METASTASIS-ASSOCIATED PROTEIN MTA3 binding#GO:0005488;transcription regulator activity#GO:0140110;enzyme binding#GO:0019899;protein binding#GO:0005515;transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714;transcription coactivator activity#GO:0003713;histone deacetylase binding#GO:0042826 negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;ATPase complex#GO:1904949;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;chromosome#GO:0005694;SWI/SNF superfamily-type complex#GO:0070603;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;transcription regulator complex#GO:0005667;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;histone deacetylase complex#GO:0000118;chromatin#GO:0000785;nucleus#GO:0005634 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=25898|UniProtKB=Q96CM3 Q96CM3 RPUSD4 PTHR21600:SF81 MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE PSEUDOURIDYLATE SYNTHASE RPUSD4, MITOCHONDRIAL isomerase activity#GO:0016853;intramolecular transferase activity#GO:0016866;catalytic activity#GO:0003824 cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;rRNA modification#GO:0000154;pseudouridine synthesis#GO:0001522;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;ribosome biogenesis#GO:0042254;RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;rRNA processing#GO:0006364 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 RNA processing factor#PC00147 HUMAN|HGNC=19143|UniProtKB=Q8NFA0 Q8NFA0 USP32 PTHR21646:SF76 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 32 ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;cysteine-type deubiquitinase activity#GO:0004843;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005 regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;positive regulation of TOR signaling#GO:0032008;regulation of biological quality#GO:0065008;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of response to stimulus#GO:0048584;regulation of protein stability#GO:0031647;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of TOR signaling#GO:0032006;positive regulation of TORC1 signaling#GO:1904263;regulation of TORC1 signaling#GO:1903432;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794 cysteine protease#PC00081 HUMAN|HGNC=7658|UniProtKB=Q09161 Q09161 NCBP1 PTHR12412:SF3 CAP BINDING PROTEIN NUCLEAR CAP-BINDING PROTEIN SUBUNIT 1 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729 negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;RNA metabolic process#GO:0016070;RNA catabolic process#GO:0006401;gene expression#GO:0010467;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;regulation of mRNA metabolic process#GO:1903311;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay#GO:0000184;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;mRNA transport#GO:0051028;establishment of RNA localization#GO:0051236;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;nucleobase-containing compound transport#GO:0015931;regulation of cellular process#GO:0050794;RNA transport#GO:0050658;RNA localization#GO:0006403;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;nuclear transport#GO:0051169;nuclear export#GO:0051168;regulation of RNA metabolic process#GO:0051252;localization#GO:0051179;nucleic acid transport#GO:0050657;nucleocytoplasmic transport#GO:0006913;negative regulation of biosynthetic process#GO:0009890;biosynthetic process#GO:0009058;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of mRNA processing#GO:0050684;negative regulation of macromolecule metabolic process#GO:0010605;macromolecule biosynthetic process#GO:0009059;nucleic acid catabolic process#GO:0141188;macromolecule localization#GO:0033036;nucleobase-containing compound catabolic process#GO:0034655;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;nitrogen compound transport#GO:0071705;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;establishment of localization#GO:0051234;transport#GO:0006810;RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907;negative regulation of cellular process#GO:0048523 membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 RNA splicing factor#PC00148 HUMAN|HGNC=20451|UniProtKB=Q8IWB7 Q8IWB7 WDFY1 PTHR46189:SF2 LD41958P WD REPEAT AND FYVE DOMAIN-CONTAINING PROTEIN 1 positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;regulation of defense response#GO:0031347;regulation of immune response#GO:0050776;regulation of intracellular signal transduction#GO:1902531;regulation of cell communication#GO:0010646;regulation of response to biotic stimulus#GO:0002831;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;positive regulation of response to biotic stimulus#GO:0002833;positive regulation of response to external stimulus#GO:0032103;regulation of innate immune response#GO:0045088;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of immune response#GO:0050778;positive regulation of defense response#GO:0031349;regulation of response to stress#GO:0080134;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of response to external stimulus#GO:0032101;positive regulation of response to stimulus#GO:0048584;positive regulation of innate immune response#GO:0045089;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of pattern recognition receptor signaling pathway#GO:0062208;positive regulation of immune system process#GO:0002684 intracellular organelle#GO:0043229;endosome#GO:0005768;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 HUMAN|HGNC=10410|UniProtKB=P62266 P62266 RPS23 PTHR11652:SF44 30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER SMALL RIBOSOMAL SUBUNIT PROTEIN US12 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 translation#GO:0006412;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;protein biosynthetic process#GO:0160307;gene expression#GO:0010467 cytosol#GO:0005829;cytosolic ribosome#GO:0022626;ribosome#GO:0005840;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;cytosolic small ribosomal subunit#GO:0022627;ribonucleoprotein complex#GO:1990904;small ribosomal subunit#GO:0015935;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202 HUMAN|HGNC=2441|UniProtKB=P0DML3 P0DML3 CSH2 PTHR11417:SF67 SOMATOTROPIN,PROLACTIN CHORIONIC SOMATOMAMMOTROPIN HORMONE 1-RELATED signaling receptor regulator activity#GO:0030545;growth factor activity#GO:0008083;receptor ligand activity#GO:0048018;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;binding#GO:0005488;cytokine receptor binding#GO:0005126;signaling receptor binding#GO:0005102;hormone receptor binding#GO:0051427;molecular function activator activity#GO:0140677;hormone activity#GO:0005179;protein binding#GO:0005515 response to chemical#GO:0042221;response to hormone#GO:0009725;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;animal organ development#GO:0048513;cell surface receptor signaling pathway#GO:0007166;cellular response to hormone stimulus#GO:0032870;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;signaling#GO:0023052;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;positive regulation of signaling#GO:0023056;animal gross anatomical part developmental process#GO:0160108;cellular response to chemical stimulus#GO:0070887;regulation of signaling#GO:0023051;response to oxygen-containing compound#GO:1901700;cellular response to nitrogen compound#GO:1901699;positive regulation of response to stimulus#GO:0048584;response to peptide hormone#GO:0043434;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;response to nutrient levels#GO:0031667;positive regulation of cellular process#GO:0048522;regulation of response to stimulus#GO:0048583;regulation of receptor signaling pathway via JAK-STAT#GO:0046425;developmental process#GO:0032502;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;cellular response to peptide hormone stimulus#GO:0071375;regulation of receptor signaling pathway via STAT#GO:1904892;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;cell communication#GO:0007154;response to nitrogen compound#GO:1901698;positive regulation of receptor signaling pathway via JAK-STAT#GO:0046427;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 peptide hormone#PC00179 HUMAN|HGNC=26036|UniProtKB=Q9NX08 Q9NX08 COMMD8 PTHR16231:SF0 COMM DOMAIN-CONTAINING PROTEIN 4-8 FAMILY MEMBER COMM DOMAIN-CONTAINING PROTEIN 8 protein complex scaffold activity#GO:0140378;structural molecule activity#GO:0005198 cell surface receptor signaling pathway#GO:0007166;response to chemical#GO:0042221;response to cytokine#GO:0034097;biological regulation#GO:0065007;response to tumor necrosis factor#GO:0034612;signal transduction#GO:0007165;cellular process#GO:0009987;cell communication#GO:0007154;tumor necrosis factor-mediated signaling pathway#GO:0033209;response to peptide#GO:1901652;cytokine-mediated signaling pathway#GO:0019221;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;cellular response to stimulus#GO:0051716 protein-containing complex#GO:0032991 HUMAN|HGNC=22985|UniProtKB=Q8TAA3 Q8TAA3 PSMA8 PTHR11599:SF144 PROTEASOME SUBUNIT ALPHA/BETA PROTEASOME SUBUNIT ALPHA-TYPE 8 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987 intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;endopeptidase complex#GO:1905369;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;peptidase complex#GO:1905368;nucleus#GO:0005634;proteasome complex#GO:0000502 protein modifying enzyme#PC00260;protease#PC00190 Parkinson disease#P00049>20S proteasome#P01227 HUMAN|HGNC=11904|UniProtKB=O00220 O00220 TNFRSF10A PTHR46330:SF13 TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10B TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10A-RELATED signaling#GO:0023052;regulation of cellular process#GO:0050794;positive regulation of programmed cell death#GO:0043068;response to stimulus#GO:0050896;extrinsic apoptotic signaling pathway#GO:0097191;cell death#GO:0008219;cellular response to stimulus#GO:0051716;apoptotic process#GO:0006915;regulation of biological process#GO:0050789;programmed cell death#GO:0012501;regulation of programmed cell death#GO:0043067;cell communication#GO:0007154;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;apoptotic signaling pathway#GO:0097190;extrinsic apoptotic signaling pathway via death domain receptors#GO:0008625;positive regulation of apoptotic process#GO:0043065;regulation of apoptotic process#GO:0042981;cell surface receptor signaling pathway#GO:0007166 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cell surface#GO:0009986;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 Apoptosis signaling pathway#P00006>TRAIL-R#P00276;p53 pathway#P00059>KILLER/DR5#G01568 HUMAN|HGNC=28351|UniProtKB=Q9BQE6 Q9BQE6 LBHD1 PTHR14987:SF1 PROTEIN LBH-RELATED LBH DOMAIN-CONTAINING PROTEIN 1 positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=15463|UniProtKB=Q9BVG9 Q9BVG9 PTDSS2 PTHR15362:SF7 PHOSPHATIDYLINOSITOL SYNTHASE PHOSPHATIDYLSERINE SYNTHASE 2 transferase#PC00220 HUMAN|HGNC=9036|UniProtKB=P0C869 P0C869 PLA2G4B PTHR10728:SF32 CYTOSOLIC PHOSPHOLIPASE A2 CYTOSOLIC PHOSPHOLIPASE A2 BETA hydrolase activity, acting on ester bonds#GO:0016788;phospholipid binding#GO:0005543;catalytic activity#GO:0003824;cation binding#GO:0043169;hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689;ion binding#GO:0043167;small molecule binding#GO:0036094;lipase activity#GO:0016298;A2-type glycerophospholipase activity#GO:0004623;phospholipase activity#GO:0120569;glycerophospholipase activity#GO:0004620;lipid binding#GO:0008289;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;binding#GO:0005488 organophosphate catabolic process#GO:0046434;glycerophospholipid catabolic process#GO:0046475;lipid metabolic process#GO:0006629;glycerolipid catabolic process#GO:0046503;metabolic process#GO:0008152;phospholipid metabolic process#GO:0006644;glycerophospholipid metabolic process#GO:0006650;glycerolipid metabolic process#GO:0046486;phospholipid catabolic process#GO:0009395;catabolic process#GO:0009056;cellular process#GO:0009987;lipid catabolic process#GO:0016042;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;organophosphate metabolic process#GO:0019637 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 phospholipase#PC00186 VEGF signaling pathway#P00056>cPLA2#P01409;Angiogenesis#P00005>PLA2#P00227;Oxidative stress response#P00046>cPLA2#P01134;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PLA2#P00855;Angiogenesis#P00005>cPLA2#P00251 HUMAN|HGNC=3489|UniProtKB=P15036 P15036 ETS2 PTHR11849:SF188 ETS PROTEIN C-ETS-2 DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;developmental process#GO:0032502;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 winged helix/forkhead transcription factor#PC00246;DNA-binding transcription factor#PC00218 HUMAN|HGNC=3507|UniProtKB=Q03828 Q03828 EVX2 PTHR46294:SF1 SEGMENTATION PROTEIN EVEN-SKIPPED HOMEOBOX EVEN-SKIPPED HOMOLOG PROTEIN 2 nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=4071|UniProtKB=Q06546 Q06546 GABPA PTHR11849:SF195 ETS GA-BINDING PROTEIN ALPHA CHAIN DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110 regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;winged helix/forkhead transcription factor#PC00246 PDGF signaling pathway#P00047>Ets#P01167 HUMAN|HGNC=12103|UniProtKB=A0A0B4J240 A0A0B4J240 TRAV10 PTHR19433:SF103 T-CELL RECEPTOR ALPHA CHAIN V REGION-RELATED T CELL RECEPTOR ALPHA VARIABLE 10 response to bacterium#GO:0009617;response to biotic stimulus#GO:0009607;response to stimulus#GO:0050896;response to other organism#GO:0051707;biological process involved in interspecies interaction between organisms#GO:0044419;response to external stimulus#GO:0009605;response to external biotic stimulus#GO:0043207 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=4516|UniProtKB=Q8IZP9 Q8IZP9 ADGRG2 PTHR12011:SF264 ADHESION G-PROTEIN COUPLED RECEPTOR ADHESION G PROTEIN-COUPLED RECEPTOR G2 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=24463|UniProtKB=Q8WUN7 Q8WUN7 UBTD2 PTHR13609:SF20 UBIQUITIN DOMAIN CONTAINING 1 PROTEIN-RELATED UBIQUITIN DOMAIN-CONTAINING PROTEIN 2 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=5392|UniProtKB=P46695 P46695 IER3 PTHR16915:SF0 IMMEDIATE EARLY RESPONSE 3 RADIATION-INDUCIBLE IMMEDIATE-EARLY GENE IEX-1 negative regulation of cell cycle#GO:0045786;negative regulation of cell cycle G2/M phase transition#GO:1902750;negative regulation of G2/M transition of mitotic cell cycle#GO:0010972;negative regulation of mitotic cell cycle phase transition#GO:1901991;cell cycle checkpoint signaling#GO:0000075;regulation of cell cycle process#GO:0010564;response to stress#GO:0006950;intrinsic apoptotic signaling pathway in response to DNA damage#GO:0008630;cellular process#GO:0009987;signal transduction#GO:0007165;intrinsic apoptotic signaling pathway#GO:0097193;regulation of mitotic cell cycle phase transition#GO:1901990;mitotic G2 DNA damage checkpoint signaling#GO:0007095;negative regulation of mitotic cell cycle#GO:0045930;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;regulation of cell cycle#GO:0051726;signaling#GO:0023052;negative regulation of cell cycle phase transition#GO:1901988;negative regulation of biological process#GO:0048519;cell cycle process#GO:0022402;apoptotic process#GO:0006915;regulation of biological process#GO:0050789;signal transduction in response to DNA damage#GO:0042770;apoptotic signaling pathway#GO:0097190;mitotic cell cycle process#GO:1903047;negative regulation of cellular process#GO:0048523;negative regulation of cell cycle process#GO:0010948;DNA damage response#GO:0006974;DNA damage checkpoint signaling#GO:0000077;biological regulation#GO:0065007;regulation of cell cycle G2/M phase transition#GO:1902749;DNA integrity checkpoint signaling#GO:0031570;regulation of mitotic cell cycle#GO:0007346;mitotic DNA integrity checkpoint signaling#GO:0044774;mitotic G2/M transition checkpoint#GO:0044818;regulation of G2/M transition of mitotic cell cycle#GO:0010389;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of cellular process#GO:0050794;mitotic cell cycle#GO:0000278;programmed cell death#GO:0012501;regulation of cell cycle phase transition#GO:1901987;cell cycle#GO:0007049;mitotic cell cycle checkpoint signaling#GO:0007093;cellular response to stimulus#GO:0051716;mitotic DNA damage checkpoint signaling#GO:0044773;cell death#GO:0008219 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 CCKR signaling map#P06959>IEX1#G06970;CCKR signaling map#P06959>IEX1#P07092;CCKR signaling map#P06959>IEX1#G07263 HUMAN|HGNC=24105|UniProtKB=Q96FJ0 Q96FJ0 STAMBPL1 PTHR12947:SF7 AMSH-LIKE PROTEASE AMSH-LIKE PROTEASE catalytic activity#GO:0003824;deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233 vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of TOR signaling#GO:0032006;endosomal transport#GO:0016197;late endosome to vacuole transport#GO:0045324;regulation of biological process#GO:0050789;cellular localization#GO:0051641;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of response to stimulus#GO:0048584;endosome transport via multivesicular body sorting pathway#GO:0032509;positive regulation of cellular process#GO:0048522;multivesicular body sorting pathway#GO:0071985;late endosome to vacuole transport via multivesicular body sorting pathway#GO:0032511;positive regulation of TORC1 signaling#GO:1904263;regulation of TORC1 signaling#GO:1903432;establishment of localization#GO:0051234;positive regulation of intracellular signal transduction#GO:1902533;vacuolar transport#GO:0007034;transport#GO:0006810;regulation of response to stimulus#GO:0048583;intracellular transport#GO:0046907;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;positive regulation of signal transduction#GO:0009967;positive regulation of TOR signaling#GO:0032008;localization#GO:0051179 endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;intracellular vesicle#GO:0097708;vesicle#GO:0031982;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 protease#PC00190;metalloprotease#PC00153 HUMAN|HGNC=20855|UniProtKB=Q8WTV1 Q8WTV1 THAP3 PTHR47120:SF1 THAP DOMAIN-CONTAINING PROTEIN 3 THAP DOMAIN-CONTAINING PROTEIN 3 HUMAN|HGNC=18293|UniProtKB=Q5JT25 Q5JT25 RAB41 PTHR24073:SF469 DRAB5-RELATED RAS-RELATED PROTEIN RAB-41 hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787 establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;endosomal transport#GO:0016197;protein localization to Golgi apparatus#GO:0034067;intracellular transport#GO:0046907;transport#GO:0006810;intracellular protein transport#GO:0006886;Golgi vesicle transport#GO:0048193;vesicle-mediated transport#GO:0016192;macromolecule localization#GO:0033036;retrograde transport, endosome to Golgi#GO:0042147;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;localization#GO:0051179;cellular localization#GO:0051641;protein transport#GO:0015031;localization within membrane#GO:0051668;protein localization to organelle#GO:0033365;cytosolic transport#GO:0016482;protein localization to membrane#GO:0072657;intra-Golgi vesicle-mediated transport#GO:0006891 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794 small GTPase#PC00208;G-protein#PC00020 HUMAN|HGNC=15718|UniProtKB=Q8J025 Q8J025 APCDD1 PTHR31021:SF2 ADENOMATOSIS POLYPOSIS COLI DOWN-REGULATED 1 PROTEIN APCDD1 Wnt-protein binding#GO:0017147;protein binding#GO:0005515;binding#GO:0005488 negative regulation of cell communication#GO:0010648;negative regulation of cellular process#GO:0048523;negative regulation of signaling#GO:0023057;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;negative regulation of Wnt signaling pathway#GO:0030178;negative regulation of response to stimulus#GO:0048585;regulation of cellular process#GO:0050794;regulation of Wnt signaling pathway#GO:0030111;negative regulation of signal transduction#GO:0009968;regulation of cell communication#GO:0010646;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HUMAN|HGNC=18754|UniProtKB=Q96EF6 Q96EF6 FBXO17 PTHR12125:SF7 F-BOX ONLY PROTEIN 6-LIKE PROTEIN F-BOX ONLY PROTEIN 17 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=26687|UniProtKB=Q8N9Z0 Q8N9Z0 ZNF610 PTHR24377:SF703 IP01015P-RELATED ZINC FINGER PROTEIN 610 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=25209|UniProtKB=Q8WUY3 Q8WUY3 PRUNE2 PTHR12112:SF11 BNIP - RELATED PROTEIN PRUNE HOMOLOG 2 programmed cell death#GO:0012501;apoptotic process#GO:0006915;cellular process#GO:0009987;cell death#GO:0008219 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 hydrolase#PC00121;metabolite interconversion enzyme#PC00262;phosphodiesterase#PC00185 HUMAN|HGNC=12718|UniProtKB=Q99986 Q99986 VRK1 PTHR11909:SF78 CASEIN KINASE-RELATED SERINE_THREONINE-PROTEIN KINASE VRK1 transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stress#GO:0006950;cell communication#GO:0007154;DNA damage response#GO:0006974;cellular response to stress#GO:0033554 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=8780|UniProtKB=P27815 P27815 PDE4A PTHR11347:SF74 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 3',5'-CYCLIC-AMP PHOSPHODIESTERASE 4A catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphoric ester hydrolase activity#GO:0042578;phosphoric diester hydrolase activity#GO:0008081;hydrolase activity#GO:0016787;cyclic-nucleotide phosphodiesterase activity#GO:0004112 regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;negative regulation of cellular process#GO:0048523;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of signal transduction#GO:0009968;regulation of cell communication#GO:0010646;negative regulation of response to stimulus#GO:0048585;regulation of cellular process#GO:0050794 phosphodiesterase#PC00185;hydrolase#PC00121 HUMAN|HGNC=8709|UniProtKB=Q9Y5G2 Q9Y5G2 PCDHGB2 PTHR24028:SF144 CADHERIN-87A PROTOCADHERIN GAMMA-B2 cellular process#GO:0009987;cell adhesion#GO:0007155 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 cadherin#PC00057;cell adhesion molecule#PC00069 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HUMAN|HGNC=12694|UniProtKB=P32241 P32241 VIPR1 PTHR45620:SF24 PDF RECEPTOR-LIKE PROTEIN-RELATED VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 1 G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;signaling receptor activity#GO:0038023 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cell communication#GO:0007154 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=28635|UniProtKB=Q6ZS86 Q6ZS86 GK5 PTHR10196:SF68 SUGAR KINASE GLYCEROL KINASE 5 kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;phosphotransferase activity, alcohol group as acceptor#GO:0016773 carbohydrate derivative biosynthetic process#GO:1901137;neutral lipid metabolic process#GO:0006638;triglyceride metabolic process#GO:0006641;lipid metabolic process#GO:0006629;acylglycerol metabolic process#GO:0006639;alcohol metabolic process#GO:0006066;metabolic process#GO:0008152;biosynthetic process#GO:0009058;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;organophosphate metabolic process#GO:0019637;organophosphate biosynthetic process#GO:0090407;carbohydrate metabolic process#GO:0005975;glycerolipid metabolic process#GO:0046486;small molecule metabolic process#GO:0044281;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793 mitochondrion#GO:0005739;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 kinase#PC00137;carbohydrate kinase#PC00065 HUMAN|HGNC=25519|UniProtKB=Q9NW15 Q9NW15 ANO10 PTHR12308:SF40 ANOCTAMIN ANOCTAMIN-10 molecular carrier activity#GO:0140104;gated channel activity#GO:0022836;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;lipid carrier activity#GO:0005319;phospholipid scramblase activity#GO:0017128;ligand-gated monoatomic ion channel activity#GO:0015276;intramembrane lipid carrier activity#GO:0140303;channel activity#GO:0015267;calcium-activated cation channel activity#GO:0005227;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;monoatomic ion-gated channel activity#GO:0022839;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;monoatomic cation channel activity#GO:0005261 transmembrane transport#GO:0055085;localization#GO:0051179;chloride transmembrane transport#GO:1902476;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698;lipid localization#GO:0010876;organophosphate ester transport#GO:0015748;lipid translocation#GO:0034204;cellular component organization#GO:0016043;monoatomic anion transport#GO:0006820;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;regulation of membrane lipid distribution#GO:0097035;chloride transport#GO:0006821;transport#GO:0006810;monoatomic anion transmembrane transport#GO:0098656;lipid transport#GO:0006869;monoatomic ion transmembrane transport#GO:0034220;phospholipid transport#GO:0015914;phospholipid translocation#GO:0045332;biological regulation#GO:0065007;membrane organization#GO:0061024;macromolecule localization#GO:0033036;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=25781|UniProtKB=Q96C12 Q96C12 ARMC5 PTHR23312:SF8 ARMC5 ARMADILLO REPEAT-CONTAINING -RELATED ARMADILLO REPEAT-CONTAINING PROTEIN 5 developmental process#GO:0032502;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856 HUMAN|HGNC=9304|UniProtKB=P63151 P63151 PPP2R2A PTHR11871:SF2 PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B ALPHA ISOFORM molecular function regulator activity#GO:0098772;protein phosphatase regulator activity#GO:0019888;phosphatase regulator activity#GO:0019208;enzyme regulator activity#GO:0030234 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;protein serine/threonine phosphatase complex#GO:0008287;catalytic complex#GO:1902494 protein phosphatase#PC00195;protein modifying enzyme#PC00260 FGF signaling pathway#P00021>PP2A#P00629 HUMAN|HGNC=15020|UniProtKB=A6NH00 A6NH00 OR2T8 PTHR26453:SF286 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2T33-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 nervous system process#GO:0050877;sensory perception#GO:0007600;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;detection of chemical stimulus#GO:0009593;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;response to chemical#GO:0042221;response to stimulus#GO:0050896 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=11122|UniProtKB=Q9UHP9 Q9UHP9 SMPX PTHR17416:SF0 SMALL MUSCULAR PROTEIN SMALL MUSCULAR PROTEIN intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;supramolecular fiber#GO:0099512;myofibril#GO:0030016;intracellular organelle#GO:0043229;M band#GO:0031430;cell-substrate junction#GO:0030055;cellular anatomical structure#GO:0110165;organelle#GO:0043226;A band#GO:0031672;membraneless organelle#GO:0043228;cell junction#GO:0030054;sarcomere#GO:0030017;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;contractile muscle fiber#GO:0043292 HUMAN|HGNC=26199|UniProtKB=Q9H079 Q9H079 KATNBL1 PTHR14682:SF1 KATNB1-LIKE PROTEIN 1 KATNB1-LIKE PROTEIN 1 cytoskeleton organization#GO:0007010;cytoplasmic microtubule organization#GO:0031122;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;microtubule-based process#GO:0007017;supramolecular fiber organization#GO:0097435;microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840 cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;membraneless organelle#GO:0043228;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226 HUMAN|HGNC=6798|UniProtKB=P43364 P43364 MAGEA11 PTHR11736:SF146 MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN MELANOMA-ASSOCIATED ANTIGEN 11 protein binding#GO:0005515;histone deacetylase binding#GO:0042826;enzyme binding#GO:0019899;binding#GO:0005488 negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 scaffold/adaptor protein#PC00226 HUMAN|HGNC=26007|UniProtKB=Q5JUW0 Q5JUW0 KRABD4 PTHR23232:SF98 KRAB DOMAIN C2H2 ZINC FINGER KRAB DOMAIN-CONTAINING PROTEIN 4 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=6140|UniProtKB=P13612 P13612 ITGA4 PTHR23220:SF78 INTEGRIN ALPHA INTEGRIN ALPHA-4 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell-matrix adhesion#GO:0007160;cell adhesion#GO:0007155;cell surface receptor signaling pathway#GO:0007166;cell-substrate adhesion#GO:0031589;cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;integrin-mediated signaling pathway#GO:0007229;cell-cell adhesion#GO:0098609;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;cell periphery#GO:0071944;protein complex involved in cell adhesion#GO:0098636;plasma membrane protein complex#GO:0098797;membrane#GO:0016020;membrane protein complex#GO:0098796;integrin complex#GO:0008305;signaling receptor complex#GO:0043235 cell adhesion molecule#PC00069;integrin#PC00126 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Integrin#P00853;Integrin signalling pathway#P00034>Integrin alpha#P00941 HUMAN|HGNC=5950|UniProtKB=O75054 O75054 IGSF3 PTHR12207:SF21 V-SET AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN IMMUNOGLOBULIN SUPERFAMILY MEMBER 3 cellular anatomical structure#GO:0110165;membrane#GO:0016020 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=24564|UniProtKB=Q4AC94 Q4AC94 C2CD3 PTHR21254:SF1 C2 DOMAIN-CONTAINING PROTEIN 3 C2 DOMAIN-CONTAINING PROTEIN 3 cell projection organization#GO:0030030;protein localization to organelle#GO:0033365;cell cycle#GO:0007049;cilium assembly#GO:0060271;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;protein localization to cytoskeleton#GO:0044380;centrosome cycle#GO:0007098;protein localization to centrosome#GO:0071539;cell cycle process#GO:0022402;protein localization to microtubule organizing center#GO:1905508;localization#GO:0051179;microtubule cytoskeleton organization#GO:0000226;cilium organization#GO:0044782;organelle assembly#GO:0070925;centriole replication#GO:0007099;protein localization to microtubule cytoskeleton#GO:0072698;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection organization#GO:0120036;macromolecule localization#GO:0033036;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;microtubule organizing center organization#GO:0031023;intracellular protein localization#GO:0008104;centrosome duplication#GO:0051298;microtubule-based process#GO:0007017;plasma membrane bounded cell projection assembly#GO:0120031 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;microtubule organizing center#GO:0005815;centrosome#GO:0005813;cytoskeleton#GO:0005856;centriolar satellite#GO:0034451;centriole#GO:0005814;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microtubule cytoskeleton#GO:0015630 HUMAN|HGNC=4536|UniProtKB=P60893 P60893 GPR85 PTHR19268:SF7 G PROTEIN-COUPLED RECEPTOR G PROTEIN-COUPLED RECEPTOR 85-RELATED transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=12502|UniProtKB=P63165 P63165 SUMO1 PTHR10562:SF148 SMALL UBIQUITIN-RELATED MODIFIER SMALL UBIQUITIN-RELATED MODIFIER 1 protein binding#GO:0005515;enzyme binding#GO:0019899;ubiquitin-like protein ligase binding#GO:0044389;binding#GO:0005488 protein modification process#GO:0036211;primary metabolic process#GO:0044238;protein modification by small protein conjugation#GO:0032446;cellular process#GO:0009987;post-translational protein modification#GO:0043687;protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;protein sumoylation#GO:0016925 membraneless organelle#GO:0043228;nuclear body#GO:0016604;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;PML body#GO:0016605;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233 p53 pathway#P00059>Sumo-1 ligase#P04635 HUMAN|HGNC=11522|UniProtKB=O75410 O75410 TACC1 PTHR13924:SF12 TRANSFORMING ACIDIC COILED-COIL CONTAINING PROTEIN 1/2 TRANSFORMING ACIDIC COILED-COIL-CONTAINING PROTEIN 1 transcription factor binding#GO:0008134;nuclear receptor binding#GO:0016922;binding#GO:0005488;DNA-binding transcription factor binding#GO:0140297;protein binding#GO:0005515;RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629 localization#GO:0051179;microtubule cytoskeleton organization#GO:0000226;anatomical structure development#GO:0048856;cellular localization#GO:0051641;supramolecular fiber organization#GO:0097435;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;organelle localization#GO:0051640;cell differentiation#GO:0030154;establishment of organelle localization#GO:0051656;cytoplasmic microtubule organization#GO:0031122;cell cycle#GO:0007049;cellular component organization#GO:0016043;nuclear migration#GO:0007097;cell cycle process#GO:0022402;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;establishment of localization#GO:0051234;microtubule-based process#GO:0007017;neurogenesis#GO:0022008;intracellular transport#GO:0046907;developmental process#GO:0032502;transport#GO:0006810;multicellular organismal process#GO:0032501;cytoskeleton organization#GO:0007010;nervous system development#GO:0007399;organelle organization#GO:0006996;establishment of localization in cell#GO:0051649;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;spindle pole#GO:0000922;microtubule cytoskeleton#GO:0015630;cytosol#GO:0005829;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;centrosome#GO:0005813;microtubule organizing center#GO:0005815;spindle#GO:0005819;intracellular organelle#GO:0043229 HUMAN|HGNC=27563|UniProtKB=A6NFC5 A6NFC5 TMEM235 PTHR20516:SF1 TRANSMEMBRANE PROTEIN 114/235 FAMILY MEMBER TRANSMEMBRANE PROTEIN 235 plasma membrane#GO:0005886;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;apical part of cell#GO:0045177;cell periphery#GO:0071944;apical plasma membrane#GO:0016324;membrane#GO:0016020 HUMAN|HGNC=9329|UniProtKB=P50391 P50391 NPY4R PTHR24235:SF25 NEUROPEPTIDE Y RECEPTOR NEUROPEPTIDE Y RECEPTOR TYPE 4-RELATED neuropeptide receptor activity#GO:0008188;transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;signaling receptor activity#GO:0038023 biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;neuropeptide signaling pathway#GO:0007218;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;neuron projection#GO:0043005;membrane#GO:0016020 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=13058|UniProtKB=O95218 O95218 ZRANB2 PTHR12999:SF21 ZINC FINGER RAN-BINDING DOMAIN-CONTAINING PROTEIN 2 ZRANB2-RELATED ZINC FINGER RAN-BINDING DOMAIN-CONTAINING PROTEIN 2 binding#GO:0005488;carbohydrate derivative binding#GO:0097367;lipopolysaccharide binding#GO:0001530;lipid binding#GO:0008289 RNA processing factor#PC00147;RNA splicing factor#PC00148 HUMAN|HGNC=6204|UniProtKB=P05412 P05412 JUN PTHR11462:SF8 JUN TRANSCRIPTION FACTOR-RELATED TRANSCRIPTION FACTOR JUN double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;response to steroid hormone#GO:0048545;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of cell population proliferation#GO:0042127;positive regulation of biosynthetic process#GO:0009891;positive regulation of biological process#GO:0048518;response to hormone#GO:0009725;response to lipid#GO:0033993;positive regulation of macromolecule metabolic process#GO:0010604;response to chemical#GO:0042221;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;regulation of cell cycle#GO:0051726;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557 transcription regulator complex#GO:0005667;protein-containing complex#GO:0032991 basic leucine zipper transcription factor#PC00056;DNA-binding transcription factor#PC00218 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>AP-1#P00838;T cell activation#P00053>jun#P01335;Angiogenesis#P00005>c-Jun#P00220;CCKR signaling map#P06959>JUN#G07276;Ras Pathway#P04393>AP1#P04560;Gonadotropin-releasing hormone receptor pathway#P06664>JUN#P06757;B cell activation#P00010>jun#P00401;FAS signaling pathway#P00020>c-Jun#P00601;Gonadotropin-releasing hormone receptor pathway#P06664>Junc#P06710;TGF-beta signaling pathway#P00052>Co-activators corepressors#P01282;PDGF signaling pathway#P00047>c-Jun#P01163;Huntington disease#P00029>c-Jun#P00776;CCKR signaling map#P06959>JUN#G06983;Gonadotropin-releasing hormone receptor pathway#P06664>Junc#G06677;Toll receptor signaling pathway#P00054>AP1#P01355;CCKR signaling map#P06959>JUN#P07114;Apoptosis signaling pathway#P00006>c-Jun#P00303;Oxidative stress response#P00046>c-jun#P01132;Gonadotropin-releasing hormone receptor pathway#P06664>Junc#G06891 HUMAN|HGNC=3415|UniProtKB=P01588 P01588 EPO PTHR10370:SF0 ERYTHROPOIETIN ERYTHROPOIETIN protein binding#GO:0005515;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;cytokine activity#GO:0005125;binding#GO:0005488;cytokine receptor binding#GO:0005126;signaling receptor activator activity#GO:0030546;kinase regulator activity#GO:0019207;protein kinase regulator activity#GO:0019887;enzyme activator activity#GO:0008047;hormone activity#GO:0005179;kinase activator activity#GO:0019209;signaling receptor binding#GO:0005102;molecular function regulator activity#GO:0098772;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;protein kinase activator activity#GO:0030295 multicellular organismal-level homeostasis#GO:0048871;cellular developmental process#GO:0048869;developmental process#GO:0032502;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;hemopoiesis#GO:0030097;cell surface receptor signaling pathway via STAT#GO:0097696;response to chemical#GO:0042221;response to cytokine#GO:0034097;multicellular organismal process#GO:0032501;signal transduction#GO:0007165;cellular process#GO:0009987;response to peptide#GO:1901652;cell communication#GO:0007154;anatomical structure development#GO:0048856;erythrocyte differentiation#GO:0030218;homeostasis of number of cells#GO:0048872;immune system process#GO:0002376;cytokine-mediated signaling pathway#GO:0019221;signaling#GO:0023052;homeostatic process#GO:0042592;cell development#GO:0048468;cell differentiation#GO:0030154;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;myeloid cell differentiation#GO:0030099;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;cellular response to stimulus#GO:0051716 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=17419|UniProtKB=Q6IS14 Q6IS14 EIF5AL1 PTHR11673:SF25 TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER EUKARYOTIC TRANSLATION INITIATION FACTOR 5A-1-LIKE translation factor activity#GO:0180051;translation elongation factor activity#GO:0003746 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;translation#GO:0006412;translational elongation#GO:0006414;metabolic process#GO:0008152;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238 translational protein#PC00263;translation factor#PC00223;translation initiation factor#PC00224 HUMAN|HGNC=18513|UniProtKB=Q9Y6X8 Q9Y6X8 ZHX2 PTHR15467:SF5 ZINC-FINGERS AND HOMEOBOXES RELATED ZINC FINGERS AND HOMEOBOXES PROTEIN 2 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;homeodomain transcription factor#PC00119 HUMAN|HGNC=2041|UniProtKB=P57739 P57739 CLDN2 PTHR12002:SF110 CLAUDIN CLAUDIN-2 paracellular tight junction channel activity#GO:0160187;transporter activity#GO:0005215 cell adhesion#GO:0007155;cell-cell junction organization#GO:0045216;cell-cell junction assembly#GO:0007043;transport#GO:0006810;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;paracellular transport#GO:0160184;establishment of localization#GO:0051234;cell junction assembly#GO:0034329;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;cell-cell adhesion#GO:0098609;cellular process#GO:0009987;cellular component assembly#GO:0022607;cell junction organization#GO:0034330 apical junction complex#GO:0043296;cell junction#GO:0030054;tight junction#GO:0070160;anchoring junction#GO:0070161;cell-cell junction#GO:0005911;membrane#GO:0016020;cell periphery#GO:0071944;bicellular tight junction#GO:0005923;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cell junction protein#PC00070;tight junction#PC00214 HUMAN|HGNC=5757|UniProtKB=A0A075B6H8 A0A075B6H8 IGKV1D-42 PTHR23267:SF388 IMMUNOGLOBULIN LIGHT CHAIN NON-FUNCTIONAL IMMUNOGLOBULIN KAPPA VARIABLE 1D-42-RELATED immune response#GO:0006955;immune system process#GO:0002376;response to stimulus#GO:0050896 protein-containing complex#GO:0032991 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=16517|UniProtKB=Q8IU80 Q8IU80 TMPRSS6 PTHR24253:SF62 TRANSMEMBRANE PROTEASE SERINE TRANSMEMBRANE PROTEASE SERINE 6 serine-type peptidase activity#GO:0008236;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;serine hydrolase activity#GO:0017171 proteolysis#GO:0006508;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein processing#GO:0016485;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058 protein modifying enzyme#PC00260;protease#PC00190;serine protease#PC00203 HUMAN|HGNC=7652|UniProtKB=O60934 O60934 NBN PTHR12162:SF0 NIBRIN-RELATED NIBRIN DNA binding#GO:0003677;damaged DNA binding#GO:0003684;nucleic acid binding#GO:0003676;binding#GO:0005488 recombinational repair#GO:0000725;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;regulation of G2/M transition of mitotic cell cycle#GO:0010389;mitotic DNA damage checkpoint signaling#GO:0044773;cellular response to stimulus#GO:0051716;cell cycle#GO:0007049;mitotic cell cycle checkpoint signaling#GO:0007093;regulation of cell cycle phase transition#GO:1901987;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mitotic cell cycle#GO:0000278;regulation of cellular process#GO:0050794;DNA damage response#GO:0006974;negative regulation of cell cycle process#GO:0010948;DNA repair#GO:0006281;negative regulation of cellular process#GO:0048523;mitotic cell cycle process#GO:1903047;macromolecule metabolic process#GO:0043170;mitotic G2/M transition checkpoint#GO:0044818;regulation of mitotic cell cycle#GO:0007346;mitotic DNA integrity checkpoint signaling#GO:0044774;DNA integrity checkpoint signaling#GO:0031570;regulation of cell cycle G2/M phase transition#GO:1902749;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;DNA damage checkpoint signaling#GO:0000077;cellular response to stress#GO:0033554;negative regulation of mitotic cell cycle#GO:0045930;mitotic G2 DNA damage checkpoint signaling#GO:0007095;regulation of mitotic cell cycle phase transition#GO:1901990;signal transduction in response to DNA damage#GO:0042770;regulation of biological process#GO:0050789;cell cycle process#GO:0022402;double-strand break repair via homologous recombination#GO:0000724;negative regulation of biological process#GO:0048519;negative regulation of cell cycle phase transition#GO:1901988;regulation of cell cycle#GO:0051726;signaling#GO:0023052;response to stimulus#GO:0050896;DNA recombination#GO:0006310;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;double-strand break repair#GO:0006302;negative regulation of cell cycle G2/M phase transition#GO:1902750;negative regulation of cell cycle#GO:0045786;signal transduction#GO:0007165;cellular process#GO:0009987;response to stress#GO:0006950;regulation of cell cycle process#GO:0010564;cell cycle checkpoint signaling#GO:0000075;negative regulation of mitotic cell cycle phase transition#GO:1901991;negative regulation of G2/M transition of mitotic cell cycle#GO:0010972 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634 damaged DNA-binding protein#PC00086;DNA metabolism protein#PC00009 HUMAN|HGNC=26395|UniProtKB=Q8N6N2 Q8N6N2 TTC9B PTHR11242:SF13 ARYL HYDROCARBON RECEPTOR INTERACTING PROTEIN RELATED TETRATRICOPEPTIDE REPEAT PROTEIN 9B metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein modification process#GO:0036211;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;protein folding#GO:0006457;protein maturation#GO:0051604;gene expression#GO:0010467 membrane#GO:0016020;cellular anatomical structure#GO:0110165 chaperone#PC00072 HUMAN|HGNC=33708|UniProtKB=A6NLP5 A6NLP5 TTC36 PTHR21405:SF0 CDNA SEQUENCE BC021608 TETRATRICOPEPTIDE REPEAT PROTEIN 36 HUMAN|HGNC=9859|UniProtKB=P52306 P52306 RAP1GDS1 PTHR10957:SF2 RAP1 GTPASE-GDP DISSOCIATION STIMULATOR 1 RAP1 GTPASE-GDP DISSOCIATION STIMULATOR 1 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=5713|UniProtKB=P01591 P01591 JCHAIN PTHR10070:SF2 IMMUNOGLOBULIN J CHAIN IMMUNOGLOBULIN J CHAIN protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488 response to stimulus#GO:0050896;humoral immune response#GO:0006959;immune system process#GO:0002376;immune response#GO:0006955 extracellular region#GO:0005576;extracellular protein-containing complex#GO:0140392;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 immunoglobulin#PC00123 HUMAN|HGNC=7795|UniProtKB=Q00653 Q00653 NFKB2 PTHR24169:SF21 NUCLEAR FACTOR NF-KAPPA-B PROTEIN NUCLEAR FACTOR NF-KAPPA-B P100 SUBUNIT transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 cell communication#GO:0007154;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;intracellular signal transduction#GO:0035556;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;response to external biotic stimulus#GO:0043207;positive regulation of RNA metabolic process#GO:0051254;cellular response to stimulus#GO:0051716;regulation of biosynthetic process#GO:0009889;innate immune response#GO:0045087;response to external stimulus#GO:0009605;defense response#GO:0006952;regulation of gene expression#GO:0010468;regulation of nucleobase-containing compound metabolic process#GO:0019219;canonical NF-kappaB signal transduction#GO:0007249;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;response to other organism#GO:0051707;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of cellular process#GO:0048522;immune response#GO:0006955;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;response to peptide#GO:1901652;immune system process#GO:0002376;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052;regulation of biological process#GO:0050789;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of macromolecule metabolic process#GO:0010604;response to cytokine#GO:0034097;response to chemical#GO:0042221;defense response to other organism#GO:0098542;intracellular signaling cassette#GO:0141124;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;defense response to symbiont#GO:0140546;positive regulation of biological process#GO:0048518;non-canonical NF-kappaB signal transduction#GO:0038061;signal transduction#GO:0007165;cellular process#GO:0009987 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 gene-specific transcriptional regulator#PC00264;Rel homology transcription factor#PC00252;DNA-binding transcription factor#PC00218 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>NFkappaB#P00859;B cell activation#P00010>NFkappaB#P00370;Apoptosis signaling pathway#P00006>NFkappaB#P00297;Toll receptor signaling pathway#P00054>NFkappaB#P01354;T cell activation#P00053>NFkappaB#P01298 HUMAN|HGNC=6907|UniProtKB=P21941 P21941 MATN1 PTHR24020:SF16 COLLAGEN ALPHA MATRILIN-1 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 extracellular matrix structural protein#PC00103 HUMAN|HGNC=29230|UniProtKB=Q9ULI0 Q9ULI0 ATAD2B PTHR23069:SF5 AAA DOMAIN-CONTAINING ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 2B ribonucleoside triphosphate phosphatase activity#GO:0017111;histone binding#GO:0042393;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ATP hydrolysis activity#GO:0016887;protein binding#GO:0005515;hydrolase activity#GO:0016787;chromatin binding#GO:0003682;ATP-dependent activity#GO:0140657;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488 nucleic acid biosynthetic process#GO:0141187;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;RNA metabolic process#GO:0016070;cellular component disassembly#GO:0022411;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;chromatin remodeling#GO:0006338;DNA-templated transcription initiation#GO:0006352;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;transcription initiation-coupled chromatin remodeling#GO:0045815;protein-containing complex organization#GO:0043933;protein-DNA complex organization#GO:0071824;cellular component organization or biogenesis#GO:0071840;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;transcription initiation at RNA polymerase II promoter#GO:0006367;positive regulation of macromolecule metabolic process#GO:0010604;gene expression#GO:0010467;positive regulation of biosynthetic process#GO:0009891;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;protein-containing complex disassembly#GO:0032984;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;transcription by RNA polymerase II#GO:0006366;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;nucleosome organization#GO:0034728;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;macromolecule biosynthetic process#GO:0009059;regulation of metabolic process#GO:0019222;epigenetic regulation of gene expression#GO:0040029;regulation of macromolecule biosynthetic process#GO:0010556;chromatin organization#GO:0006325;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;biosynthetic process#GO:0009058 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=6485|UniProtKB=O15230 O15230 LAMA5 PTHR10574:SF448 NETRIN/LAMININ-RELATED LAMININ SUBUNIT ALPHA-5 structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 multicellular organismal process#GO:0032501;tissue development#GO:0009888;cell morphogenesis involved in neuron differentiation#GO:0048667;plasma membrane bounded cell projection organization#GO:0120036;nervous system development#GO:0007399;axon development#GO:0061564;axon guidance#GO:0007411;neuron projection development#GO:0031175;cellular process#GO:0009987;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;neurogenesis#GO:0022008;neuron projection guidance#GO:0097485;cell projection morphogenesis#GO:0048858;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron projection morphogenesis#GO:0048812;neuron differentiation#GO:0030182;developmental process#GO:0032502;cell morphogenesis#GO:0000902;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell development#GO:0048468;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;axonogenesis#GO:0007409;neuron development#GO:0048666;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576;basement membrane#GO:0005604;cellular anatomical structure#GO:0110165 extracellular matrix protein#PC00102 Integrin signalling pathway#P00034>Laminin#P00947 HUMAN|HGNC=12845|UniProtKB=O60688 O60688 YPEL1 PTHR13848:SF1 PROTEIN YIPPEE-LIKE CG15309-RELATED PROTEIN YIPPEE-LIKE 1 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=38040|UniProtKB=A0A087WYE8 A0A087WYE8 IGHV1OR21-1 PTHR23266:SF100 IMMUNOGLOBULIN HEAVY CHAIN IG-LIKE DOMAIN-CONTAINING PROTEIN binding#GO:0005488;antigen binding#GO:0003823 response to stimulus#GO:0050896;adaptive immune response#GO:0002250;immune response#GO:0006955;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449;immunoglobulin mediated immune response#GO:0016064;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immune system process#GO:0002376;immune effector process#GO:0002252 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=24904|UniProtKB=Q70IA6 Q70IA6 MOB2 PTHR22599:SF21 MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB MOB KINASE ACTIVATOR 2 enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;kinase activator activity#GO:0019209;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;protein kinase regulator activity#GO:0019887;enzyme activator activity#GO:0008047;protein kinase activator activity#GO:0030295 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell communication#GO:0007154 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 kinase activator#PC00138 HUMAN|HGNC=26984|UniProtKB=Q4VC39 Q4VC39 HIGD2B PTHR12297:SF8 HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED HIG1 DOMAIN FAMILY MEMBER 2B cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;cellular component assembly#GO:0022607;mitochondrion organization#GO:0007005;mitochondrial respiratory chain complex assembly#GO:0033108 mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 scaffold/adaptor protein#PC00226 HUMAN|HGNC=9760|UniProtKB=P62491 P62491 RAB11A PTHR47979:SF110 DRAB11-RELATED RAS-RELATED PROTEIN RAB-11A nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;GTPase activity#GO:0003924;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;guanyl nucleotide binding#GO:0019001 endosome to plasma membrane protein transport#GO:0099638;vesicle localization#GO:0051648;macromolecule localization#GO:0033036;biological regulation#GO:0065007;transport#GO:0006810;regulation of postsynaptic membrane neurotransmitter receptor levels#GO:0099072;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;vesicle-mediated transport to the plasma membrane#GO:0098876;establishment of localization#GO:0051234;protein localization to plasma membrane#GO:0072659;pigmentation#GO:0043473;establishment of protein localization to plasma membrane#GO:0061951;localization within membrane#GO:0051668;organelle localization#GO:0051640;protein localization to cell junction#GO:1902414;secretion#GO:0046903;localization#GO:0051179;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;establishment of protein localization to membrane#GO:0090150;cellular pigmentation#GO:0033059;establishment of vesicle localization#GO:0051650;vesicle-mediated transport#GO:0016192;intracellular protein transport#GO:0006886;protein localization to cell periphery#GO:1990778;neurotransmitter receptor transport to postsynaptic membrane#GO:0098969;exocytosis#GO:0006887;endosomal transport#GO:0016197;protein localization to synapse#GO:0035418;protein localization to membrane#GO:0072657;export from cell#GO:0140352;establishment of organelle localization#GO:0051656;endocytic recycling#GO:0032456;protein transport#GO:0015031;regulation of biological quality#GO:0065008;secretion by cell#GO:0032940;cellular localization#GO:0051641 cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;intracellular organelle#GO:0043229;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;postsynapse#GO:0098794;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cell junction#GO:0030054;Golgi apparatus#GO:0005794;recycling endosome#GO:0055037;endomembrane system#GO:0012505;transport vesicle#GO:0030133;cytoplasm#GO:0005737 small GTPase#PC00208;G-protein#PC00020 HUMAN|HGNC=26928|UniProtKB=Q9UKY7 Q9UKY7 CDV3 PTHR16284:SF13 PROTEIN CDV3 HOMOLOG PROTEIN CDV3 HOMOLOG cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=19372|UniProtKB=Q6EBC2 Q6EBC2 IL31 PTHR38652:SF1 INTERLEUKIN-31 INTERLEUKIN-31 signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;cytokine receptor binding#GO:0005126;signaling receptor binding#GO:0005102;binding#GO:0005488;cytokine activity#GO:0005125;molecular function activator activity#GO:0140677;protein binding#GO:0005515 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 interleukin superfamily#PC00128;cytokine#PC00083 HUMAN|HGNC=1406|UniProtKB=Q9Y698 Q9Y698 CACNG2 PTHR12107:SF1 VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA SUBUNIT VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-2 SUBUNIT monoatomic cation channel activity#GO:0005261;molecular function regulator activity#GO:0098772;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;voltage-gated calcium channel activity#GO:0005245;channel activity#GO:0015267;channel regulator activity#GO:0016247;transporter regulator activity#GO:0141108;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;transporter activity#GO:0005215;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836 regulation of biological process#GO:0050789;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;localization within membrane#GO:0051668;nervous system process#GO:0050877;regulation of signaling#GO:0023051;positive regulation of synaptic transmission#GO:0050806;regulation of biological quality#GO:0065008;cell communication#GO:0007154;localization#GO:0051179;regulation of synaptic transmission, glutamatergic#GO:0051966;positive regulation of signaling#GO:0023056;cellular localization#GO:0051641;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regulation of trans-synaptic signaling#GO:0099177;regulation of postsynaptic membrane neurotransmitter receptor levels#GO:0099072;transmission of nerve impulse#GO:0019226;system process#GO:0003008 membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane region#GO:0098590;postsynaptic specialization#GO:0099572;neuron to neuron synapse#GO:0098984;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane#GO:0005886;synaptic membrane#GO:0097060;signaling receptor complex#GO:0043235;cell junction#GO:0030054;transporter complex#GO:1990351;membrane protein complex#GO:0098796;postsynapse#GO:0098794;plasma membrane protein complex#GO:0098797;organelle#GO:0043226;asymmetric synapse#GO:0032279;cellular anatomical structure#GO:0110165;synapse#GO:0045202;postsynaptic specialization membrane#GO:0099634;postsynaptic membrane#GO:0045211;postsynaptic density#GO:0014069;transmembrane transporter complex#GO:1902495;postsynaptic density membrane#GO:0098839 voltage-gated ion channel#PC00241;transporter#PC00227;ion channel#PC00133 Ionotropic glutamate receptor pathway#P00037>stargazin#P00998 HUMAN|HGNC=253|UniProtKB=P11766 P11766 ADH5 PTHR43880:SF4 ALCOHOL DEHYDROGENASE ALCOHOL DEHYDROGENASE CLASS-3 alcohol dehydrogenase (NAD+) activity#GO:0004022;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;zinc ion binding#GO:0008270;cation binding#GO:0043169;metal ion binding#GO:0046872;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;transition metal ion binding#GO:0046914;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455 response to toxic substance#GO:0009636;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;catabolic process#GO:0009056;small molecule catabolic process#GO:0044282;cellular detoxification of aldehyde#GO:0110095;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;cellular detoxification#GO:1990748;response to oxygen-containing compound#GO:1901700;response to chemical#GO:0042221;cellular response to toxic substance#GO:0097237;aldehyde catabolic process#GO:0046185;detoxification#GO:0098754;aldehyde metabolic process#GO:0006081;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;metabolic process#GO:0008152 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 dehydrogenase#PC00092 HUMAN|HGNC=21674|UniProtKB=Q8NA03 Q8NA03 FSIP1 PTHR22012:SF2 FIBROUS SHEATH INTERACTING PROTEIN 1 FIBROUS SHEATH-INTERACTING PROTEIN 1 HUMAN|HGNC=25019|UniProtKB=Q9Y547 Q9Y547 IFT25 PTHR33906:SF1 INTRAFLAGELLAR TRANSPORT PROTEIN 25 HOMOLOG INTRAFLAGELLAR TRANSPORT PROTEIN 25 HOMOLOG cellular process#GO:0009987;signal transduction#GO:0007165;biological regulation#GO:0065007;male gamete generation#GO:0048232;cell surface receptor signaling pathway#GO:0007166;spermatogenesis#GO:0007283;developmental process#GO:0032502;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;developmental process involved in reproduction#GO:0003006;reproductive process#GO:0022414;signaling#GO:0023052;gamete generation#GO:0007276;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;sexual reproduction#GO:0019953;multicellular organismal reproductive process#GO:0048609;smoothened signaling pathway#GO:0007224;cell communication#GO:0007154 plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cilium#GO:0005929;intraciliary transport particle#GO:0030990;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;intraciliary transport particle B#GO:0030992;cytoskeleton#GO:0005856;centrosome#GO:0005813;microtubule organizing center#GO:0005815 HUMAN|HGNC=20233|UniProtKB=Q9Y2Z9 Q9Y2Z9 COQ6 PTHR43876:SF7 UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152;biosynthetic process#GO:0009058;small molecule metabolic process#GO:0044281;ketone biosynthetic process#GO:0042181;cellular process#GO:0009987;ubiquinone biosynthetic process#GO:0006744;ketone metabolic process#GO:0042180 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739 oxygenase#PC00177;oxidoreductase#PC00176 HUMAN|HGNC=15218|UniProtKB=Q8NGJ2 Q8NGJ2 OR52H1 PTHR26450:SF123 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 52H1 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=3049|UniProtKB=Q14126 Q14126 DSG2 PTHR24025:SF1 DESMOGLEIN FAMILY MEMBER DESMOGLEIN-2 ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;calcium ion binding#GO:0005509;metal ion binding#GO:0046872;cation binding#GO:0043169 cell-cell adhesion#GO:0098609;cellular process#GO:0009987;cell adhesion#GO:0007155 cell-cell junction#GO:0005911;cellular anatomical structure#GO:0110165;cell junction#GO:0030054;anchoring junction#GO:0070161 cadherin#PC00057 HUMAN|HGNC=855|UniProtKB=P27449 P27449 ATP6V0C PTHR10263:SF5 V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT V-TYPE PROTON ATPASE 16 KDA PROTEOLIPID SUBUNIT C cellular anatomical structure#GO:0110165;membrane#GO:0016020 ATP synthase#PC00002;primary active transporter#PC00068 HUMAN|HGNC=3023|UniProtKB=P14416 P14416 DRD2 PTHR24248:SF87 ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR D(2) DOPAMINE RECEPTOR signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;postsynaptic neurotransmitter receptor activity#GO:0098960;transmembrane signaling receptor activity#GO:0004888;neurotransmitter receptor activity#GO:0030594 G protein-coupled dopamine receptor signaling pathway#GO:0007212;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987;response to chemical#GO:0042221;cellular response to nitrogen compound#GO:1901699;regulation of trans-synaptic signaling#GO:0099177;biological regulation#GO:0065007;adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway#GO:0007193;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;negative regulation of cellular process#GO:0048523;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;modulation of chemical synaptic transmission#GO:0050804;signaling#GO:0023052;regulation of cell communication#GO:0010646;G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887;negative regulation of signaling#GO:0023057;response to oxygen-containing compound#GO:1901700;regulation of signaling#GO:0023051;cell communication#GO:0007154;regulation of synaptic transmission, glutamatergic#GO:0051966;response to nitrogen compound#GO:1901698;negative regulation of cell communication#GO:0010648;adrenergic receptor signaling pathway#GO:0071875 synaptic membrane#GO:0097060;cell junction#GO:0030054;membrane#GO:0016020;cell periphery#GO:0071944;presynapse#GO:0098793;cellular anatomical structure#GO:0110165;synapse#GO:0045202;glutamatergic synapse#GO:0098978;plasma membrane region#GO:0098590;presynaptic membrane#GO:0042734;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 Gonadotropin-releasing hormone receptor pathway#P06664>DRD2#P06758;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GoPCR#P00725;Dopamine receptor mediated signaling pathway#P05912>D2/D3/D4#P05965;Nicotine pharmacodynamics pathway#P06587>DRD2/ DRD3/ DRD4#P06603;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711 HUMAN|HGNC=23090|UniProtKB=Q8N697 Q8N697 SLC15A4 PTHR11654:SF80 OLIGOPEPTIDE TRANSPORTER-RELATED SOLUTE CARRIER FAMILY 15 MEMBER 4 aromatic amino acid transmembrane transporter activity#GO:0015173;basic amino acid transmembrane transporter activity#GO:0015174;carboxylic acid transmembrane transporter activity#GO:0046943;L-amino acid transmembrane transporter activity#GO:0015179;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;oligopeptide transmembrane transporter activity#GO:0035673;dipeptide transmembrane transporter activity#GO:0071916;amino acid transmembrane transporter activity#GO:0015171 amino acid transport#GO:0006865;transport#GO:0006810;oligopeptide transport#GO:0006857;localization#GO:0051179;dipeptide transport#GO:0042938;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;import into cell#GO:0098657;oligopeptide transmembrane transport#GO:0035672;cellular process#GO:0009987;peptide transport#GO:0015833;nitrogen compound transport#GO:0071705;import across plasma membrane#GO:0098739 cellular anatomical structure#GO:0110165;membrane#GO:0016020 transporter#PC00227 HUMAN|HGNC=16378|UniProtKB=Q7RTW8 Q7RTW8 OTOA PTHR23412:SF18 STEREOCILIN RELATED OTOANCORIN cellular process#GO:0009987;cell adhesion#GO:0007155;cell-matrix adhesion#GO:0007160;cell-substrate adhesion#GO:0031589 cellular anatomical structure#GO:0110165;cell surface#GO:0009986 cell adhesion molecule#PC00069 HUMAN|HGNC=4705|UniProtKB=P15421 P15421 GYPE PTHR13813:SF4 GLYCOPHORIN GLYCOPHORIN-E cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 HUMAN|HGNC=8861|UniProtKB=P02776 P02776 PF4 PTHR12015:SF211 SMALL INDUCIBLE CYTOKINE A PLATELET FACTOR 4 signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;chemokine activity#GO:0008009;G protein-coupled receptor binding#GO:0001664;chemokine receptor binding#GO:0042379;protein binding#GO:0005515;molecular function activator activity#GO:0140677;cytokine activity#GO:0005125;cytokine receptor binding#GO:0005126;signaling receptor binding#GO:0005102;binding#GO:0005488 cellular response to biotic stimulus#GO:0071216;cellular response to stimulus#GO:0051716;cell motility#GO:0048870;response to external biotic stimulus#GO:0043207;locomotion#GO:0040011;response to bacterium#GO:0009617;chemotaxis#GO:0006935;inflammatory response#GO:0006954;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;cell chemotaxis#GO:0060326;immune response#GO:0006955;cell migration#GO:0016477;response to other organism#GO:0051707;leukocyte migration#GO:0050900;cellular response to molecule of bacterial origin#GO:0071219;response to external stimulus#GO:0009605;myeloid leukocyte migration#GO:0097529;leukocyte chemotaxis#GO:0030595;defense response#GO:0006952;response to molecule of bacterial origin#GO:0002237;response to stimulus#GO:0050896;granulocyte chemotaxis#GO:0071621;biological process involved in interspecies interaction between organisms#GO:0044419;cellular response to chemical stimulus#GO:0070887;immune system process#GO:0002376;response to oxygen-containing compound#GO:1901700;response to biotic stimulus#GO:0009607;cellular response to lipopolysaccharide#GO:0071222;response to stress#GO:0006950;cellular response to oxygen-containing compound#GO:1901701;defense response to symbiont#GO:0140546;cellular process#GO:0009987;taxis#GO:0042330;neutrophil migration#GO:1990266;response to chemical#GO:0042221;granulocyte migration#GO:0097530;cellular response to lipid#GO:0071396;defense response to other organism#GO:0098542;response to lipid#GO:0033993;neutrophil chemotaxis#GO:0030593;humoral immune response#GO:0006959;antimicrobial humoral response#GO:0019730;response to lipopolysaccharide#GO:0032496 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 cytokine#PC00083 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CHK#P00856 HUMAN|HGNC=29805|UniProtKB=Q9BYH8 Q9BYH8 NFKBIZ PTHR24124:SF5 ANKYRIN REPEAT FAMILY A NF-KAPPA-B INHIBITOR ZETA regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 protein-binding activity modulator#PC00095 HUMAN|HGNC=18653|UniProtKB=Q8WZ60 Q8WZ60 KLHL6 PTHR24412:SF428 KELCH PROTEIN KELCH-LIKE PROTEIN 6 enzyme-substrate adaptor activity#GO:0140767;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238 intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;Cul3-RING ubiquitin ligase complex#GO:0031463;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;transferase complex#GO:1990234;cullin-RING ubiquitin ligase complex#GO:0031461;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=14865|UniProtKB=Q8N693 Q8N693 ESX1 PTHR24329:SF545 HOMEOBOX PROTEIN ARISTALESS HOMEOBOX PROTEIN ESX1 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 cell development#GO:0048468;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;neuron development#GO:0048666;system development#GO:0048731;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;nervous system development#GO:0007399;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;multicellular organism development#GO:0007275;developmental process#GO:0032502;neuron differentiation#GO:0030182 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 gene-specific transcriptional regulator#PC00264;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=7095|UniProtKB=O15344 O15344 MID1 PTHR24099:SF23 E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED E3 UBIQUITIN-PROTEIN LIGASE MIDLINE-1 regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of microtubule cytoskeleton organization#GO:0070507;regulation of microtubule-based process#GO:0032886 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=19027|UniProtKB=Q8IWT6 Q8IWT6 LRRC8A PTHR45752:SF23 LEUCINE-RICH REPEAT-CONTAINING VOLUME-REGULATED ANION CHANNEL SUBUNIT LRRC8A monoatomic anion channel activity#GO:0005253;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;monoatomic anion transmembrane transporter activity#GO:0008509;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216 signaling#GO:0023052;import across plasma membrane#GO:0098739;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;monoatomic anion transmembrane transport#GO:0098656;signal transduction#GO:0007165;cellular process#GO:0009987;import into cell#GO:0098657;acidic amino acid transport#GO:0015800;carboxylic acid transport#GO:0046942;amino acid transport#GO:0006865;organic acid transport#GO:0015849;carboxylic acid transmembrane transport#GO:1905039;nucleobase-containing compound transport#GO:0015931;organophosphate ester transport#GO:0015748;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;carbohydrate derivative transport#GO:1901264;monoatomic anion transport#GO:0006820;intracellular signal transduction#GO:0035556;localization#GO:0051179;cell communication#GO:0007154;amino acid transmembrane transport#GO:0003333;biological regulation#GO:0065007;dicarboxylic acid transport#GO:0006835;monoatomic ion transmembrane transport#GO:0034220;aspartate transmembrane transport#GO:0015810;nitrogen compound transport#GO:0071705;establishment of localization#GO:0051234;C4-dicarboxylate transport#GO:0015740;transport#GO:0006810 transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HUMAN|HGNC=12974|UniProtKB=O15541 O15541 RNF113A PTHR12930:SF2 ZINC FINGER PROTEIN 183 E3 UBIQUITIN-PROTEIN LIGASE RNF113A aminoacyltransferase activity#GO:0016755;ubiquitin-protein transferase activity#GO:0004842;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824 RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071 nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;U2-type spliceosomal complex#GO:0005684;intracellular membrane-bounded organelle#GO:0043231;spliceosomal complex#GO:0005681;nucleus#GO:0005634 RNA metabolism protein#PC00031;RNA splicing factor#PC00148;RNA processing factor#PC00147 HUMAN|HGNC=23501|UniProtKB=O94933 O94933 SLITRK3 PTHR45773:SF6 SLIT AND NTRK-LIKE PROTEIN 4-RELATED SLIT AND NTRK-LIKE PROTEIN 3 regulation of biological quality#GO:0065008;axonogenesis#GO:0007409;neuron development#GO:0048666;positive regulation of cellular component organization#GO:0051130;generation of neurons#GO:0048699;regulation of synapse organization#GO:0050807;animal gross anatomical part developmental process#GO:0160108;regulation of cellular component biogenesis#GO:0044087;cell development#GO:0048468;cell differentiation#GO:0030154;cell projection organization#GO:0030030;regulation of cellular component organization#GO:0051128;positive regulation of nervous system development#GO:0051962;cell morphogenesis#GO:0000902;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;regulation of multicellular organismal development#GO:2000026;positive regulation of multicellular organismal process#GO:0051240;cellular component organization#GO:0016043;cell projection morphogenesis#GO:0048858;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;regulation of multicellular organismal process#GO:0051239;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;positive regulation of cellular component biogenesis#GO:0044089;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;neuron projection development#GO:0031175;system development#GO:0048731;regulation of synapse structure or activity#GO:0050803;regulation of nervous system development#GO:0051960;anatomical structure development#GO:0048856;regulation of cell junction assembly#GO:1901888;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;positive regulation of synapse assembly#GO:0051965;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;developmental process#GO:0032502;positive regulation of developmental process#GO:0051094;neuron projection morphogenesis#GO:0048812;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;regulation of synapse assembly#GO:0051963;multicellular organismal process#GO:0032501;positive regulation of cellular process#GO:0048522;axon development#GO:0061564 cell junction#GO:0030054;synaptic membrane#GO:0097060;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;neuron to neuron synapse#GO:0098984;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;postsynaptic density membrane#GO:0098839;postsynaptic specialization membrane#GO:0099634;postsynaptic membrane#GO:0045211;postsynaptic density#GO:0014069;organelle#GO:0043226;asymmetric synapse#GO:0032279;cellular anatomical structure#GO:0110165;synapse#GO:0045202;GABA-ergic synapse#GO:0098982;postsynapse#GO:0098794 transmembrane signal receptor#PC00197 HUMAN|HGNC=18756|UniProtKB=Q9BYZ6 Q9BYZ6 RHOBTB2 PTHR24072:SF137 RHO FAMILY GTPASE RHO-RELATED BTB DOMAIN-CONTAINING PROTEIN 2 hydrolase activity#GO:0016787;GTPase activity#GO:0003924;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;protein binding#GO:0005515;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;guanyl nucleotide binding#GO:0019001;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;kinase binding#GO:0019900;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639 cortical cytoskeleton organization#GO:0030865;establishment or maintenance of cell polarity#GO:0007163;actin filament-based process#GO:0030029;cell communication#GO:0007154;regulation of biological quality#GO:0065008;supramolecular fiber organization#GO:0097435;cellular component organization#GO:0016043;cellular response to stimulus#GO:0051716;regulation of organelle organization#GO:0033043;regulation of cell shape#GO:0008360;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;actin cytoskeleton organization#GO:0030036;response to stimulus#GO:0050896;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;regulation of developmental process#GO:0050793;signaling#GO:0023052;regulation of actin filament-based process#GO:0032970;regulation of anatomical structure morphogenesis#GO:0022603;cellular component organization or biogenesis#GO:0071840;actin filament organization#GO:0007015;organelle organization#GO:0006996;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of actin cytoskeleton organization#GO:0032956;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010 cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;intracellular membrane-bounded organelle#GO:0043231 small GTPase#PC00208;G-protein#PC00020 HUMAN|HGNC=8111|UniProtKB=Q8TAX0 Q8TAX0 OSR1 PTHR14196:SF5 ODD-SKIPPED - RELATED PROTEIN ODD-SKIPPED-RELATED 1 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;animal gross anatomical part developmental process#GO:0160108;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;multicellular organism development#GO:0007275;animal organ development#GO:0048513;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;kidney development#GO:0001822;renal system development#GO:0072001;negative regulation of macromolecule biosynthetic process#GO:0010558;system development#GO:0048731;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;pattern specification process#GO:0007389;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 zinc finger transcription factor#PC00244;DNA-binding transcription factor#PC00218 HUMAN|HGNC=37473|UniProtKB=P0CW01 P0CW01 TSPY10 PTHR11875:SF12 TESTIS-SPECIFIC Y-ENCODED PROTEIN TESTIS-SPECIFIC Y-ENCODED PROTEIN 1-RELATED protein binding#GO:0005515;binding#GO:0005488;chromatin binding#GO:0003682;histone binding#GO:0042393 chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=940|UniProtKB=O95429 O95429 BAG4 PTHR12329:SF10 BCL2-ASSOCIATED ATHANOGENE BAG FAMILY MOLECULAR CHAPERONE REGULATOR 4 nucleoside-triphosphatase regulator activity#GO:0060589;protein binding#GO:0005515;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;protein-folding chaperone binding#GO:0051087;binding#GO:0005488 regulation of protein stability#GO:0031647;regulation of biological quality#GO:0065008;protein stabilization#GO:0050821;biological regulation#GO:0065007 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;membrane#GO:0016020;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 chaperone#PC00072 Apoptosis signaling pathway#P00006>SODD#P00320 HUMAN|HGNC=30628|UniProtKB=Q96BD6 Q96BD6 SPSB1 PTHR12245:SF8 SPRY DOMAIN CONTAINING SOCS BOX PROTEIN SPRY DOMAIN-CONTAINING SOCS BOX PROTEIN 1 enzyme-substrate adaptor activity#GO:0140767;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238 transferase complex#GO:1990234;catalytic complex#GO:1902494;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;cullin-RING ubiquitin ligase complex#GO:0031461;SCF ubiquitin ligase complex#GO:0019005;intracellular protein-containing complex#GO:0140535 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=16490|UniProtKB=Q6V1X1 Q6V1X1 DPP8 PTHR11731:SF98 PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED DIPEPTIDYL PEPTIDASE 8 catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;exopeptidase activity#GO:0008238;hydrolase activity#GO:0016787;peptidase activity#GO:0008233 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;metabolic process#GO:0008152;proteolysis#GO:0006508;cellular process#GO:0009987 serine protease#PC00203;protease#PC00190 HUMAN|HGNC=12382|UniProtKB=Q9H0U9 Q9H0U9 TSPYL1 PTHR11875:SF108 TESTIS-SPECIFIC Y-ENCODED PROTEIN TESTIS-SPECIFIC Y-ENCODED-LIKE PROTEIN 1 binding#GO:0005488;chromatin binding#GO:0003682;histone binding#GO:0042393;protein binding#GO:0005515 intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;chromosome#GO:0005694;nucleus#GO:0005634;chromatin#GO:0000785;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=13138|UniProtKB=Q9UC07 Q9UC07 ZNF69 PTHR24381:SF244 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 439-RELATED transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=7828|UniProtKB=Q86X76 Q86X76 NIT1 PTHR23088:SF27 NITRILASE-RELATED DEAMINATED GLUTATHIONE AMIDASE hydrolase#PC00121 HUMAN|HGNC=561|UniProtKB=O95782 O95782 AP2A1 PTHR22780:SF33 ADAPTIN, ALPHA/GAMMA/EPSILON AP-2 COMPLEX SUBUNIT ALPHA-1 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;cargo adaptor activity#GO:0140312 clathrin-dependent endocytosis#GO:0072583;cellular process#GO:0009987;endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;transport#GO:0006810;receptor-mediated endocytosis#GO:0006898;establishment of localization#GO:0051234;import into cell#GO:0098657;localization#GO:0051179 endocytic vesicle#GO:0030139;coated vesicle#GO:0030135;coated membrane#GO:0048475;intracellular organelle#GO:0043229;coated vesicle membrane#GO:0030662;organelle#GO:0043226;cellular anatomical structure#GO:0110165;clathrin coat#GO:0030118;clathrin-coated pit#GO:0005905;intracellular vesicle#GO:0097708;AP-type membrane coat adaptor complex#GO:0030119;bounding membrane of organelle#GO:0098588;clathrin-coated endocytic vesicle#GO:0045334;clathrin-coated vesicle membrane#GO:0030665;clathrin vesicle coat#GO:0030125;vesicle coat#GO:0030120;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane coat#GO:0030117;intracellular membrane-bounded organelle#GO:0043231;vesicle#GO:0031982;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;organelle membrane#GO:0031090;clathrin-coated vesicle#GO:0030136;plasma membrane#GO:0005886;endomembrane system#GO:0012505;cell periphery#GO:0071944;vesicle membrane#GO:0012506;membrane#GO:0016020 membrane traffic protein#PC00150 Huntington disease#P00029>alpha-Adaptin#P00782 HUMAN|HGNC=6265|UniProtKB=P48050 P48050 KCNJ4 PTHR11767:SF53 INWARD RECTIFIER POTASSIUM CHANNEL INWARD RECTIFIER POTASSIUM CHANNEL 4 monoatomic cation channel activity#GO:0005261;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276;potassium channel activity#GO:0005267;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;transporter activity#GO:0005215;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated monoatomic ion channel activity#GO:0005244;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836 inorganic ion import across plasma membrane#GO:0099587;metal ion transport#GO:0030001;import across plasma membrane#GO:0098739;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;potassium ion transport#GO:0006813;cellular process#GO:0009987;inorganic cation import across plasma membrane#GO:0098659;establishment of localization#GO:0051234;import into cell#GO:0098657;potassium ion import across plasma membrane#GO:1990573;transport#GO:0006810 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 ion channel#PC00133 HUMAN|HGNC=23785|UniProtKB=Q9Y2I7 Q9Y2I7 PIKFYVE PTHR46715:SF1 1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE 1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphatidylinositol kinase activity#GO:0052742;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773;lipid kinase activity#GO:0001727 pigmentation#GO:0043473;chemotaxis#GO:0006935;organelle assembly#GO:0070925;vacuole organization#GO:0007033;cell chemotaxis#GO:0060326;localization#GO:0051179;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;locomotion#GO:0040011;phospholipid metabolic process#GO:0006644;vesicle fusion#GO:0006906;regulation of cellular process#GO:0050794;cell motility#GO:0048870;lipid metabolic process#GO:0006629;lytic vacuole organization#GO:0080171;transport#GO:0006810;phagocytosis#GO:0006909;leukocyte migration#GO:0050900;leukocyte chemotaxis#GO:0030595;response to external stimulus#GO:0009605;myeloid leukocyte migration#GO:0097529;establishment of localization#GO:0051234;regulation of biosynthetic process#GO:0009889;regulation of metabolic process#GO:0019222;membrane fusion#GO:0061025;organophosphate metabolic process#GO:0019637;membrane organization#GO:0061024;biological regulation#GO:0065007;cell migration#GO:0016477;regulation of reactive oxygen species metabolic process#GO:2000377;cellular response to chemical stimulus#GO:0070887;immune system process#GO:0002376;regulation of biological process#GO:0050789;phosphorus metabolic process#GO:0006793;cellular component organization#GO:0016043;endocytosis#GO:0006897;glycerolipid metabolic process#GO:0046486;response to stimulus#GO:0050896;granulocyte chemotaxis#GO:0071621;melanosome organization#GO:0032438;phagolysosome assembly#GO:0001845;metabolic process#GO:0008152;neutrophil chemotaxis#GO:0030593;vesicle organization#GO:0016050;import into cell#GO:0098657;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;lysosome organization#GO:0007040;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular pigmentation#GO:0033059;organelle membrane fusion#GO:0090174;vesicle-mediated transport#GO:0016192;granulocyte migration#GO:0097530;organelle fusion#GO:0048284;response to chemical#GO:0042221;neutrophil migration#GO:1990266;glycerophospholipid metabolic process#GO:0006650;taxis#GO:0042330;cellular component assembly#GO:0022607 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;endocytic vesicle#GO:0030139;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasmic vesicle membrane#GO:0030659;phagocytic vesicle#GO:0045335;cytoplasm#GO:0005737;membrane#GO:0016020;vesicle membrane#GO:0012506;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090 transferase#PC00220;metabolite interconversion enzyme#PC00262;kinase#PC00137 HUMAN|HGNC=30809|UniProtKB=Q92519 Q92519 TRIB2 PTHR22961:SF15 SER/THR PROTEIN KINASE-TRB TRIBBLES HOMOLOG 2 binding#GO:0005488;kinase binding#GO:0019900;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;protein binding#GO:0005515 regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of proteasomal protein catabolic process#GO:1901800;regulation of biological process#GO:0050789;positive regulation of ubiquitin-dependent protein catabolic process#GO:2000060;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434;positive regulation of metabolic process#GO:0009893;positive regulation of protein catabolic process#GO:0045732;regulation of protein catabolic process#GO:0042176;positive regulation of protein metabolic process#GO:0051247;positive regulation of macromolecule metabolic process#GO:0010604;regulation of proteasomal protein catabolic process#GO:0061136;biological regulation#GO:0065007;positive regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032436;regulation of primary metabolic process#GO:0080090;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of catabolic process#GO:0009896;regulation of catabolic process#GO:0009894;regulation of ubiquitin-dependent protein catabolic process#GO:2000058 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=13589|UniProtKB=Q9UK96 Q9UK96 FBXO10 PTHR22990:SF33 F-BOX ONLY PROTEIN F-BOX ONLY PROTEIN 10 enzyme-substrate adaptor activity#GO:0140767;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;modification-dependent protein catabolic process#GO:0019941;regulation of biological process#GO:0050789;primary metabolic process#GO:0044238;regulation of programmed cell death#GO:0043067;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of apoptotic process#GO:0042981;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;proteasomal protein catabolic process#GO:0010498;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 ubiquitin-protein ligase#PC00234 HUMAN|Ensembl=ENSG00000292234.1|UniProtKB=A0AAG2UXZ5 A0AAG2UXZ5 COL18A1 PTHR24023:SF1034 COLLAGEN ALPHA COLLAGEN ALPHA-1(XVIII) CHAIN-RELATED extracellular matrix structural constituent#GO:0005201;structural molecule activity#GO:0005198 vasculature development#GO:0001944;anatomical structure formation involved in morphogenesis#GO:0048646;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;developmental process#GO:0032502;endothelial cell differentiation#GO:0045446;tube development#GO:0035295;epithelium development#GO:0060429;multicellular organismal process#GO:0032501;tissue development#GO:0009888;epithelial cell differentiation#GO:0030855;cellular process#GO:0009987;external encapsulating structure organization#GO:0045229;system development#GO:0048731;skeletal system development#GO:0001501;angiogenesis#GO:0001525;anatomical structure development#GO:0048856;extracellular matrix organization#GO:0030198;animal gross anatomical part developmental process#GO:0160108;extracellular structure organization#GO:0043062;cell development#GO:0048468;cell differentiation#GO:0030154;circulatory system development#GO:0072359;cell morphogenesis#GO:0000902;anatomical structure morphogenesis#GO:0009653;blood vessel development#GO:0001568;tube morphogenesis#GO:0035239;cellular component organization#GO:0016043;blood vessel morphogenesis#GO:0048514 external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 Integrin signalling pathway#P00034>Collagen#P00922 HUMAN|HGNC=25274|UniProtKB=Q53FE4 Q53FE4 C4orf17 PTHR33772:SF2 THYMUS, BRAIN AND TESTES-ASSOCIATED RIKEN CDNA 4930579F01 GENE HUMAN|HGNC=21601|UniProtKB=Q9H1N7 Q9H1N7 SLC35B3 PTHR10778:SF8 SOLUTE CARRIER FAMILY 35 MEMBER B ADENOSINE 3'-PHOSPHO 5'-PHOSPHOSULFATE TRANSPORTER 2 nucleobase-containing compound transmembrane transporter activity#GO:0015932;organophosphate ester transmembrane transporter activity#GO:0015605;purine nucleotide transmembrane transporter activity#GO:0015216;carbohydrate derivative transmembrane transporter activity#GO:1901505;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;transport#GO:0006810;nucleobase-containing compound transport#GO:0015931;organophosphate ester transport#GO:0015748;nitrogen compound transport#GO:0071705;carbohydrate derivative transport#GO:1901264;cellular process#GO:0009987 endoplasmic reticulum#GO:0005783;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane#GO:0016020;cytoplasm#GO:0005737;endomembrane system#GO:0012505;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258 HUMAN|HGNC=24674|UniProtKB=Q8TES7 Q8TES7 FBF1 PTHR33689:SF1 FAS-BINDING FACTOR 1 FAS-BINDING FACTOR 1 cell projection organization#GO:0030030;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782;plasma membrane bounded cell projection assembly#GO:0120031;organelle assembly#GO:0070925 cilium#GO:0005929;intracellular organelle#GO:0043229;microtubule organizing center#GO:0005815;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;centriole#GO:0005814;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=12224|UniProtKB=A0A0A0MS05 A0A0A0MS05 TRBV5-7 PTHR23268:SF6 T-CELL RECEPTOR BETA CHAIN T CELL RECEPTOR BETA VARIABLE 5-5-RELATED cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=16176|UniProtKB=Q9H171 Q9H171 ZBP1 PTHR14966:SF0 Z-DNA-BINDING PROTEIN 1 Z-DNA-BINDING PROTEIN 1 nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690 positive regulation of response to biotic stimulus#GO:0002833;response to external stimulus#GO:0009605;defense response#GO:0006952;regulation of innate immune response#GO:0045088;innate immune response#GO:0045087;positive regulation of immune response#GO:0050778;positive regulation of defense response#GO:0031349;regulation of response to stimulus#GO:0048583;regulation of response to stress#GO:0080134;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;response to other organism#GO:0051707;positive regulation of response to stimulus#GO:0048584;positive regulation of cellular process#GO:0048522;immune response#GO:0006955;positive regulation of innate immune response#GO:0045089;response to virus#GO:0009615;regulation of immune response#GO:0050776;regulation of defense response#GO:0031347;response to external biotic stimulus#GO:0043207;regulation of response to biotic stimulus#GO:0002831;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of immune system process#GO:0002682;antiviral innate immune response#GO:0140374;positive regulation of signal transduction#GO:0009967;regulation of cytokine-mediated signaling pathway#GO:0001959;positive regulation of apoptotic process#GO:0043065;positive regulation of response to external stimulus#GO:0032103;regulation of apoptotic process#GO:0042981;regulation of response to external stimulus#GO:0032101;defense response to other organism#GO:0098542;positive regulation of biological process#GO:0048518;defense response to symbiont#GO:0140546;response to biotic stimulus#GO:0009607;positive regulation of immune system process#GO:0002684;regulation of response to cytokine stimulus#GO:0060759;response to stress#GO:0006950;positive regulation of cytokine-mediated signaling pathway#GO:0001961;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;immune system process#GO:0002376;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;positive regulation of programmed cell death#GO:0043068;regulation of biological process#GO:0050789;defense response to virus#GO:0051607;regulation of programmed cell death#GO:0043067 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634 DNA metabolism protein#PC00009 HUMAN|HGNC=15759|UniProtKB=Q16186 Q16186 ADRM1 PTHR12225:SF0 ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN PROTEASOMAL UBIQUITIN RECEPTOR ADRM1 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;enzyme-substrate adaptor activity#GO:0140767 ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;catabolic process#GO:0009056;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238 catalytic complex#GO:1902494;intracellular organelle#GO:0043229;endopeptidase complex#GO:1905369;proteasome regulatory particle, lid subcomplex#GO:0008541;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;proteasome complex#GO:0000502;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;peptidase complex#GO:1905368;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=10312|UniProtKB=P84098 P84098 RPL19 PTHR10722:SF48 60S RIBOSOMAL PROTEIN L19 LARGE RIBOSOMAL SUBUNIT PROTEIN EL19 nucleic acid binding#GO:0003676;binding#GO:0005488;structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198;RNA binding#GO:0003723 cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;ribosome#GO:0005840;cytosolic large ribosomal subunit#GO:0022625;cytosolic ribosome#GO:0022626;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904 ribosomal protein#PC00202 HUMAN|HGNC=3814|UniProtKB=O75593 O75593 FOXH1 PTHR47316:SF1 FORKHEAD BOX PROTEIN H1 FORKHEAD BOX PROTEIN H1 winged helix/forkhead transcription factor#PC00246 TGF-beta signaling pathway#P00052>Co-activators corepressors#P01282 HUMAN|HGNC=24757|UniProtKB=Q6IPR3 Q6IPR3 TYW3 PTHR23245:SF31 TRNA METHYLTRANSFERASE TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 3 HOMOLOG transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;transferase activity#GO:0016740;RNA methyltransferase activity#GO:0008173;catalytic activity, acting on RNA#GO:0140098;tRNA methyltransferase activity#GO:0008175;methyltransferase activity#GO:0008168;catalytic activity, acting on a tRNA#GO:0140101 RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187;macromolecule methylation#GO:0043414;macromolecule modification#GO:0043412;methylation#GO:0032259;RNA metabolic process#GO:0016070;RNA methylation#GO:0001510;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;tRNA modification#GO:0006400;RNA biosynthetic process#GO:0032774;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;macromolecule biosynthetic process#GO:0009059;tRNA methylation#GO:0030488;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 RNA methyltransferase#PC00033 HUMAN|HGNC=15381|UniProtKB=Q8NGA8 Q8NGA8 OR4F17 PTHR48002:SF51 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 4F17-RELATED olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=52|UniProtKB=Q5T3U5 Q5T3U5 ABCC10 PTHR24223:SF330 ATP-BINDING CASSETTE SUB-FAMILY C ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 10 primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804;xenobiotic transmembrane transporter activity#GO:0042910;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657 transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 ATP-binding cassette (ABC) transporter#PC00003 HUMAN|HGNC=660|UniProtKB=P36406 P36406 TRIM23 PTHR11711:SF163 ADP RIBOSYLATION FACTOR-RELATED E3 UBIQUITIN-PROTEIN LIGASE TRIM23 guanyl nucleotide binding#GO:0019001;small molecule binding#GO:0036094;anion binding#GO:0043168;binding#GO:0005488;nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;ribonucleotide binding#GO:0032553;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555 intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907;protein transport#GO:0015031;intracellular protein localization#GO:0008104;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;macromolecule localization#GO:0033036;vesicle-mediated transport#GO:0016192 cytoplasm#GO:0005737;vacuole#GO:0005773;lysosomal membrane#GO:0005765;membrane#GO:0016020;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;vacuolar membrane#GO:0005774;lytic vacuole#GO:0000323;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;lysosome#GO:0005764;lytic vacuole membrane#GO:0098852;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 G-protein#PC00020 HUMAN|HGNC=12310|UniProtKB=Q15650 Q15650 TRIP4 PTHR12963:SF6 THYROID RECEPTOR INTERACTING PROTEIN RELATED ACTIVATING SIGNAL COINTEGRATOR 1 ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;translational elongation#GO:0006414;metabolic process#GO:0008152;proteasomal protein catabolic process#GO:0010498;biosynthetic process#GO:0009058;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component disassembly#GO:0022411;protein metabolic process#GO:0019538;organelle disassembly#GO:1903008;translation#GO:0006412;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein biosynthetic process#GO:0160307;cytoplasmic translation#GO:0002181;catabolic process#GO:0009056;rescue of stalled cytosolic ribosome#GO:0072344;modification-dependent protein catabolic process#GO:0019941;cellular component organization#GO:0016043;primary metabolic process#GO:0044238 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HUMAN|HGNC=29972|UniProtKB=Q8NHQ1 Q8NHQ1 CEP70 PTHR14594:SF1 CENTROSOMAL PROTEIN OF 70 KDA CENTROSOMAL PROTEIN OF 70 KDA cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component assembly#GO:0022607;cell projection organization#GO:0030030;plasma membrane bounded cell projection organization#GO:0120036;organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031;cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;intracellular organelle#GO:0043229 HUMAN|HGNC=2476|UniProtKB=P01036 P01036 CST4 PTHR46186:SF3 CYSTATIN CYSTATIN-S-RELATED enzyme inhibitor activity#GO:0004857;endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;peptidase regulator activity#GO:0061134;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;cysteine-type endopeptidase inhibitor activity#GO:0004869 vesicle#GO:0031982;extracellular region#GO:0005576;membrane-bounded organelle#GO:0043227;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 protease inhibitor#PC00191 HUMAN|HGNC=11391|UniProtKB=Q9UQB9 Q9UQB9 AURKC PTHR24350:SF3 SERINE/THREONINE-PROTEIN KINASE IAL-RELATED AURORA KINASE C protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096 regulation of cell cycle process#GO:0010564;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;cellular process#GO:0009987;organelle organization#GO:0006996;mitotic cell cycle process#GO:1903047;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;spindle organization#GO:0007051;regulation of cell cycle#GO:0051726;mitotic cell cycle#GO:0000278;regulation of cellular process#GO:0050794;mitotic spindle organization#GO:0007052;regulation of biological process#GO:0050789;cell cycle process#GO:0022402;cell cycle#GO:0007049;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cellular component organization#GO:0016043;microtubule cytoskeleton organization#GO:0000226;regulation of cell division#GO:0051302;regulation of cytokinesis#GO:0032465 condensed chromosome, centromeric region#GO:0000779;microtubule cytoskeleton#GO:0015630;nucleus#GO:0005634;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;chromosome, centromeric region#GO:0000775;condensed chromosome#GO:0000793;microtubule organizing center#GO:0005815;spindle#GO:0005819;centrosome#GO:0005813;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;chromosome#GO:0005694;midbody#GO:0030496;spindle pole#GO:0000922;kinetochore#GO:0000776;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;spindle microtubule#GO:0005876;microtubule#GO:0005874;spindle midzone#GO:0051233;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;supramolecular fiber#GO:0099512 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=13974|UniProtKB=P18615 P18615 NELFE PTHR17250:SF0 NEGATIVE ELONGATION FACTOR E NEGATIVE ELONGATION FACTOR E regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;regulation of transcription elongation by RNA polymerase II#GO:0034243;regulation of DNA-templated transcription elongation#GO:0032784;negative regulation of metabolic process#GO:0009892;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;transcription elongation factor complex#GO:0008023;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;protein-containing complex#GO:0032991 HUMAN|HGNC=11927|UniProtKB=O43508 O43508 TNFSF12 PTHR15151:SF20 PROTEIN EIGER TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 12 receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;cytokine activity#GO:0005125;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546 apoptotic signaling pathway#GO:0097190;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;signal transduction#GO:0007165;immune response#GO:0006955;cellular process#GO:0009987;cell communication#GO:0007154;immune system process#GO:0002376;signaling#GO:0023052;extrinsic apoptotic signaling pathway#GO:0097191;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;apoptotic process#GO:0006915;cell death#GO:0008219;cellular response to stimulus#GO:0051716;programmed cell death#GO:0012501 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HUMAN|HGNC=9358|UniProtKB=P48147 P48147 PREP PTHR42881:SF2 PROLYL ENDOPEPTIDASE PROLYL ENDOPEPTIDASE peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;catalytic activity#GO:0003824 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protease#PC00190;serine protease#PC00203 Vasopressin synthesis#P04395>Endo Peptidase#P04596 HUMAN|HGNC=18742|UniProtKB=Q9UL41 Q9UL41 PNMA3 PTHR23095:SF22 PARANEOPLASTIC ANTIGEN PARANEOPLASTIC ANTIGEN MA3 transcription cofactor#PC00217 HUMAN|HGNC=17384|UniProtKB=Q6ZNA4 Q6ZNA4 RNF111 PTHR16200:SF4 RING ZINC FINGER E3 UBIQUITIN-PROTEIN LIGASE ARKADIA ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;protein binding#GO:0005515;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;binding#GO:0005488;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740 positive regulation of response to stimulus#GO:0048584;regulation of cellular response to growth factor stimulus#GO:0090287;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;regulation of response to stimulus#GO:0048583;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of cell communication#GO:0010646;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092;positive regulation of signal transduction#GO:0009967;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;modification-dependent protein catabolic process#GO:0019941;regulation of transforming growth factor beta receptor signaling pathway#GO:0017015;protein metabolic process#GO:0019538;positive regulation of signaling#GO:0023056;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;regulation of signaling#GO:0023051 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=9976|UniProtKB=O60858 O60858 TRIM13 PTHR24103:SF609 E3 UBIQUITIN-PROTEIN LIGASE TRIM E3 UBIQUITIN-PROTEIN LIGASE TRIM13 acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 response to biotic stimulus#GO:0009607;positive regulation of autophagy#GO:0010508;response to stress#GO:0006950;defense response to symbiont#GO:0140546;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;response to chemical#GO:0042221;defense response to other organism#GO:0098542;proteasomal protein catabolic process#GO:0010498;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;positive regulation of canonical NF-kappaB signal transduction#GO:0043123;regulation of macroautophagy#GO:0016241;regulation of autophagy#GO:0010506;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;positive regulation of macroautophagy#GO:0016239;immune system process#GO:0002376;regulation of intracellular signal transduction#GO:1902531;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;regulation of signaling#GO:0023051;positive regulation of metabolic process#GO:0009893;positive regulation of signaling#GO:0023056;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;immune response#GO:0006955;regulation of canonical NF-kappaB signal transduction#GO:0043122;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;response to other organism#GO:0051707;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;macromolecule metabolic process#GO:0043170;positive regulation of catabolic process#GO:0009896;innate immune response#GO:0045087;response to external stimulus#GO:0009605;regulation of catabolic process#GO:0009894;defense response#GO:0006952;positive regulation of signal transduction#GO:0009967;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;catabolic process#GO:0009056;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;response to external biotic stimulus#GO:0043207;regulation of cell communication#GO:0010646;response to endoplasmic reticulum stress#GO:0034976;protein metabolic process#GO:0019538;ERAD pathway#GO:0036503 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=1500|UniProtKB=Q92851 Q92851 CASP10 PTHR10454:SF240 CASPASE CASPASE-10 catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;cysteine-type endopeptidase activity#GO:0004197;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234 biological regulation#GO:0065007;regulation of cellular process#GO:0050794;positive regulation of programmed cell death#GO:0043068;regulation of biological process#GO:0050789;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;cell death#GO:0008219;apoptotic process#GO:0006915;regulation of neuron apoptotic process#GO:0043523;regulation of programmed cell death#GO:0043067;programmed cell death#GO:0012501;positive regulation of apoptotic process#GO:0043065;regulation of apoptotic process#GO:0042981;positive regulation of neuron apoptotic process#GO:0043525 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;plasma membrane#GO:0005886;membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;intracellular anatomical structure#GO:0005622 protease#PC00190;protein modifying enzyme#PC00260 Huntington disease#P00029>Caspase 8#P00808;FAS signaling pathway#P00020>Pro-Caspase10#P00598;Apoptosis signaling pathway#P00006>Caspase 10#P00295;Huntington disease#P00029>Pro-caspase 8#P00767;FAS signaling pathway#P00020>Caspase8#P00594;FAS signaling pathway#P00020>Pro-Caspase8#P00604;FAS signaling pathway#P00020>Caspase10#P00606;Apoptosis signaling pathway#P00006>Caspase 8#P00299 HUMAN|HGNC=25500|UniProtKB=Q8IYM2 Q8IYM2 SLFN12 PTHR12155:SF2 SCHLAFEN RIBONUCLEASE SLFN12 endoribonuclease#PC00094 HUMAN|HGNC=21694|UniProtKB=P78424 P78424 POU6F2 PTHR11636:SF68 POU DOMAIN POU DOMAIN, CLASS 6, TRANSCRIPTION FACTOR 2 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090 organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=29187|UniProtKB=Q9UPS6 Q9UPS6 SETD1B PTHR45814:SF1 HISTONE-LYSINE N-METHYLTRANSFERASE SETD1 HISTONE-LYSINE N-METHYLTRANSFERASE SETD1B catalytic activity, acting on a protein#GO:0140096;protein methyltransferase activity#GO:0008276;transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;catalytic activity#GO:0003824;histone modifying activity#GO:0140993;histone H3 methyltransferase activity#GO:0140938;histone H3K4 methyltransferase activity#GO:0042800;lysine N-methyltransferase activity#GO:0016278;N-methyltransferase activity#GO:0008170;protein-lysine N-methyltransferase activity#GO:0016279;histone methyltransferase activity#GO:0042054;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757 organelle lumen#GO:0043233;methyltransferase complex#GO:0034708;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;transferase complex#GO:1990234;histone methyltransferase complex#GO:0035097;nuclear protein-containing complex#GO:0140513;Set1C/COMPASS complex#GO:0048188 histone modifying enzyme#PC00261 HUMAN|HGNC=10989|UniProtKB=Q00325 Q00325 SLC25A3 PTHR45671:SF10 SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED SOLUTE CARRIER FAMILY 25 MEMBER 3 active transmembrane transporter activity#GO:0022804;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;phosphate transmembrane transporter activity#GO:0005315;secondary active transmembrane transporter activity#GO:0015291 cellular process#GO:0009987;transport#GO:0006810;phosphate ion transport#GO:0006817;inorganic anion transport#GO:0015698;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;organelle envelope#GO:0031967;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 mitochondrial carrier protein#PC00158 HUMAN|HGNC=11617|UniProtKB=Q15369 Q15369 ELOC PTHR20648:SF13 ELONGIN-C ELONGIN-C protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 catabolic process#GO:0009056;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632 transcription elongation factor complex#GO:0008023;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;protein-containing complex#GO:0032991;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 general transcription factor#PC00259 HUMAN|HGNC=22966|UniProtKB=P60331 P60331 KRTAP10-1 PTHR23262:SF206 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 10-1-RELATED structural protein#PC00211 HUMAN|HGNC=18169|UniProtKB=Q96AY3 Q96AY3 FKBP10 PTHR46046:SF3 PEPTIDYLPROLYL ISOMERASE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP10 HUMAN|HGNC=18944|UniProtKB=Q3LI61 Q3LI61 KRTAP20-2 PTHR39653:SF7 KERATIN-ASSOCIATED PROTEIN 20-2 KERATIN-ASSOCIATED PROTEIN 20-2 structural protein#PC00211 HUMAN|HGNC=2203|UniProtKB=P08572 P08572 COL4A2 PTHR24023:SF588 COLLAGEN ALPHA COLLAGEN ALPHA-2(IV) CHAIN structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;cellular component organization#GO:0016043;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;extracellular matrix organization#GO:0030198;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;external encapsulating structure organization#GO:0045229;extracellular structure organization#GO:0043062;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;cellular component organization or biogenesis#GO:0071840;cell surface receptor signaling pathway#GO:0007166 cellular anatomical structure#GO:0110165;basement membrane#GO:0005604;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 Integrin signalling pathway#P00034>Collagen#P00922 HUMAN|HGNC=4035|UniProtKB=Q16570 Q16570 ACKR1 PTHR14181:SF1 DUFFY ANTIGEN/CHEMOKINE RECEPTOR ATYPICAL CHEMOKINE RECEPTOR 1 immune receptor activity#GO:0140375;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;cytokine receptor activity#GO:0004896;transmembrane signaling receptor activity#GO:0004888 defense response#GO:0006952;response to stimulus#GO:0050896;inflammatory response#GO:0006954;response to stress#GO:0006950 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=133|UniProtKB=Q6S545 Q6S545 POTEH PTHR24118:SF56 POTE ANKYRIN DOMAIN POTE ANKYRIN DOMAIN FAMILY MEMBER G-RELATED transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714;transcription regulator activity#GO:0140110 regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;regulation of cell communication#GO:0010646;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of non-canonical NF-kappaB signal transduction#GO:1901222 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227 membrane traffic protein#PC00150 HUMAN|HGNC=12288|UniProtKB=P03979 P03979 TRGV3 PTHR19256:SF65 T-CELL RECEPTOR GAMMA CHAIN T CELL RECEPTOR GAMMA VARIABLE 3-RELATED immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=8258|UniProtKB=Q8NGU4 Q8NGU4 OR2I1 PTHR26453:SF216 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2I1-RELATED transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 response to stimulus#GO:0050896;response to chemical#GO:0042221;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;detection of chemical stimulus#GO:0009593;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;system process#GO:0003008;sensory perception#GO:0007600;nervous system process#GO:0050877;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=9520|UniProtKB=Q16557 Q16557 PSG3 PTHR44427:SF12 CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 19 PREGNANCY-SPECIFIC BETA-1-GLYCOPROTEIN 3 cell adhesion molecule#PC00069 HUMAN|HGNC=29608|UniProtKB=Q86UE4 Q86UE4 MTDH PTHR23251:SF0 LYSINE-RICH CEACAM1 CO-ISOLATED PROTEIN LYRIC PROTEIN PROTEIN LYRIC transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;binding#GO:0005488;transcription factor binding#GO:0008134;DNA-binding transcription factor binding#GO:0140297;protein binding#GO:0005515;RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=10421|UniProtKB=P61247 P61247 RPS3A PTHR11830:SF28 40S RIBOSOMAL PROTEIN S3A SMALL RIBOSOMAL SUBUNIT PROTEIN ES1 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 protein biosynthetic process#GO:0160307;gene expression#GO:0010467;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;translation#GO:0006412 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 translational protein#PC00263;ribosomal protein#PC00202 HUMAN|HGNC=4724|UniProtKB=P04908 P04908 H2AC4 PTHR23430:SF398 HISTONE H2A HISTONE H2A TYPE 1-B_E structural molecule activity#GO:0005198 biological regulation#GO:0065007;chromatin organization#GO:0006325;negative regulation of biosynthetic process#GO:0009890;heterochromatin organization#GO:0070828;cellular component assembly#GO:0022607;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;epigenetic regulation of gene expression#GO:0040029;regulation of gene expression#GO:0010468;cellular component organization or biogenesis#GO:0071840;negative regulation of gene expression, epigenetic#GO:0045814;regulation of biosynthetic process#GO:0009889;negative regulation of cellular process#GO:0048523;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;heterochromatin formation#GO:0031507;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629 chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;nucleosome#GO:0000786;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;protein-DNA complex#GO:0032993;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=20436|UniProtKB=Q86SH2 Q86SH2 ZAR1 PTHR31054:SF6 ZYGOTE ARREST PROTEIN 1-LIKE ISOFORM X1 ZYGOTE ARREST PROTEIN 1 RNA binding#GO:0003723;mRNA 3'-UTR binding#GO:0003730;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;cell maturation#GO:0048469;developmental process#GO:0032502;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;developmental maturation#GO:0021700;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;multicellular organismal reproductive process#GO:0048609;anatomical structure development#GO:0048856;sexual reproduction#GO:0019953;negative regulation of protein metabolic process#GO:0051248;reproductive process#GO:0022414;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;germ cell development#GO:0007281;anatomical structure maturation#GO:0071695;developmental process involved in reproduction#GO:0003006;oogenesis#GO:0048477;cellular process#GO:0009987;regulation of protein metabolic process#GO:0051246;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of translation#GO:0017148;cell development#GO:0048468;cellular process involved in reproduction in multicellular organism#GO:0022412;negative regulation of metabolic process#GO:0009892;gamete generation#GO:0007276;cell differentiation#GO:0030154;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=17995|UniProtKB=Q9BX84 Q9BX84 TRPM6 PTHR13800:SF15 TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6 TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 6 channel activity#GO:0015267;catalytic activity, acting on a protein#GO:0140096;monoatomic cation channel activity#GO:0005261;passive transmembrane transporter activity#GO:0022803;catalytic activity#GO:0003824;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773;calcium ion transmembrane transporter activity#GO:0015085;protein kinase activity#GO:0004672;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;transferase activity#GO:0016740;transporter activity#GO:0005215;kinase activity#GO:0016301 transport#GO:0006810;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;localization#GO:0051179;calcium ion transport#GO:0006816;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001 apical part of cell#GO:0045177;cell periphery#GO:0071944;apical plasma membrane#GO:0016324;membrane#GO:0016020;plasma membrane#GO:0005886;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165 ion channel#PC00133;transporter#PC00227 HUMAN|HGNC=16821|UniProtKB=P78316 P78316 NOP14 PTHR23183:SF0 NOP14 NUCLEOLAR PROTEIN 14 nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;maturation of SSU-rRNA#GO:0030490;RNA processing#GO:0006396;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;ribosomal small subunit biogenesis#GO:0042274;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;preribosome#GO:0030684;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;90S preribosome#GO:0030686;organelle lumen#GO:0043233;small-subunit processome#GO:0032040;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 RNA metabolism protein#PC00031 HUMAN|HGNC=28819|UniProtKB=Q6ZV89 Q6ZV89 SH2D5 PTHR15832:SF3 SHC (SRC HOMOLOGY DOMAIN C-TERMINAL) ADAPTOR HOMOLOG SH2 DOMAIN-CONTAINING PROTEIN 5 cell junction#GO:0030054;postsynaptic density#GO:0014069;neuron to neuron synapse#GO:0098984;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;asymmetric synapse#GO:0032279;postsynaptic specialization#GO:0099572;postsynapse#GO:0098794 scaffold/adaptor protein#PC00226 HUMAN|HGNC=6494|UniProtKB=Q9Y6N6 Q9Y6N6 LAMC3 PTHR10574:SF240 NETRIN/LAMININ-RELATED LAMININ SUBUNIT GAMMA-3 anatomical structure development#GO:0048856;system development#GO:0048731;neuron development#GO:0048666;axonogenesis#GO:0007409;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell morphogenesis#GO:0000902;cell development#GO:0048468;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;cell projection morphogenesis#GO:0048858;neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;neuron differentiation#GO:0030182;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;plasma membrane bounded cell projection morphogenesis#GO:0120039;multicellular organismal process#GO:0032501;tissue development#GO:0009888;plasma membrane bounded cell projection organization#GO:0120036;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;neuron projection development#GO:0031175;axon guidance#GO:0007411;axon development#GO:0061564;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;basement membrane#GO:0005604;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012 extracellular matrix protein#PC00102 Integrin signalling pathway#P00034>Laminin#P00947 HUMAN|HGNC=27696|UniProtKB=Q2TAA2 Q2TAA2 IAH1 PTHR14209:SF19 ISOAMYL ACETATE-HYDROLYZING ESTERASE 1 ISOAMYL ACETATE-HYDROLYZING ESTERASE 1 HOMOLOG hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788 hydrolase#PC00121;esterase#PC00097;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=2902|UniProtKB=Q92796 Q92796 DLG3 PTHR23119:SF28 DISCS LARGE DISKS LARGE HOMOLOG 3 structural constituent of synapse#GO:0098918;protein binding#GO:0005515;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;signaling receptor binding#GO:0005102;kinase binding#GO:0019900;binding#GO:0005488;structural molecule activity#GO:0005198 developmental process#GO:0032502;regulation of postsynaptic membrane neurotransmitter receptor levels#GO:0099072;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;multicellular organismal process#GO:0032501;localization within membrane#GO:0051668;establishment or maintenance of bipolar cell polarity#GO:0061245;protein localization to cell junction#GO:1902414;trans-synaptic signaling#GO:0099537;establishment or maintenance of apical/basal cell polarity#GO:0035088;system development#GO:0048731;establishment or maintenance of epithelial cell apical/basal polarity#GO:0045197;localization#GO:0051179;cell communication#GO:0007154;anatomical structure development#GO:0048856;chemical synaptic transmission#GO:0007268;anterograde trans-synaptic signaling#GO:0098916;multicellular organism development#GO:0007275;protein localization to synapse#GO:0035418;cellular process#GO:0009987;synaptic signaling#GO:0099536;cell-cell adhesion#GO:0098609;nervous system development#GO:0007399;receptor clustering#GO:0043113;cell adhesion#GO:0007155;establishment or maintenance of cell polarity#GO:0007163;animal gross anatomical part developmental process#GO:0160108;regulation of biological quality#GO:0065008;cellular localization#GO:0051641;regulation of biological process#GO:0050789;protein localization to membrane#GO:0072657;signaling#GO:0023052 synaptic membrane#GO:0097060;neuromuscular junction#GO:0031594;cell junction#GO:0030054;cell periphery#GO:0071944;neuron projection#GO:0043005;membrane#GO:0016020;plasma membrane#GO:0005886;neuron to neuron synapse#GO:0098984;plasma membrane region#GO:0098590;postsynaptic specialization#GO:0099572;postsynaptic density#GO:0014069;postsynaptic specialization membrane#GO:0099634;postsynaptic membrane#GO:0045211;postsynaptic density membrane#GO:0098839;postsynapse#GO:0098794;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;asymmetric synapse#GO:0032279 scaffold/adaptor protein#PC00226 HUMAN|HGNC=15023|UniProtKB=Q8NHC6 Q8NHC6 OR14L1 PTHR26452:SF933 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 14I1-RELATED transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 nervous system process#GO:0050877;sensory perception#GO:0007600;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=13001|UniProtKB=P17025 P17025 ZNF182 PTHR24377:SF218 IP01015P-RELATED ZINC FINGER PROTEIN 182 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=16050|UniProtKB=Q86YW9 Q86YW9 MED12L PTHR46007:SF3 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12-LIKE PROTEIN transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription coactivator activity#GO:0003713 regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of transcription by RNA polymerase II#GO:0045944;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090 organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;mediator complex#GO:0016592;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 general transcription factor#PC00259 HUMAN|HGNC=29431|UniProtKB=Q9H792 Q9H792 PEAK1 PTHR22972:SF5 SERINE/THREONINE PROTEIN KINASE INACTIVE TYROSINE-PROTEIN KINASE PEAK1 kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096 regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cell motility#GO:2000145;regulation of locomotion#GO:0040012;biological regulation#GO:0065007 actin cytoskeleton#GO:0015629;cell-substrate junction#GO:0030055;intracellular membraneless organelle#GO:0043232;focal adhesion#GO:0005925;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;anchoring junction#GO:0070161;intracellular anatomical structure#GO:0005622;cell junction#GO:0030054;membraneless organelle#GO:0043228 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=6181|UniProtKB=Q14571 Q14571 ITPR2 PTHR13715:SF53 RYANODINE RECEPTOR AND IP3 RECEPTOR INOSITOL 1,4,5-TRISPHOSPHATE-GATED CALCIUM CHANNEL ITPR2 metal ion transmembrane transporter activity#GO:0046873;alcohol binding#GO:0043178;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;calcium ion transmembrane transporter activity#GO:0015085;ligand-gated calcium channel activity#GO:0099604;monoatomic cation transmembrane transporter activity#GO:0008324;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;gated channel activity#GO:0022836;binding#GO:0005488;monoatomic cation channel activity#GO:0005261;calcium channel activity#GO:0005262;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;phosphatidylinositol binding#GO:0035091;cation binding#GO:0043169;channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094 phospholipase C-activating G protein-coupled receptor signaling pathway#GO:0007200;G protein-coupled receptor signaling pathway#GO:0007186;monoatomic ion transport#GO:0006811;localization#GO:0051179;cell communication#GO:0007154;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;calcium ion transmembrane transport#GO:0070588;metal ion transport#GO:0030001;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;transport#GO:0006810;calcium ion transport#GO:0006816;establishment of localization#GO:0051234;calcium ion transmembrane import into cytosol#GO:0097553;signal transduction#GO:0007165;cellular process#GO:0009987;release of sequestered calcium ion into cytosol#GO:0051209;biological regulation#GO:0065007;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220 intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;sarcoplasm#GO:0016528;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;organelle subcompartment#GO:0031984;vesicle#GO:0031982;secretory granule membrane#GO:0030667;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;cell periphery#GO:0071944;sarcoplasmic reticulum#GO:0016529;membrane#GO:0016020;secretory vesicle#GO:0099503;vesicle membrane#GO:0012506;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505 ligand-gated ion channel#PC00141;ion channel#PC00133 Wnt signaling pathway#P00057>IP3 Gated Calcium Channel#P01426;Angiotensin II-stimulated signaling through G proteins and beta-arrestin#P05911>IP3R#P05932;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>IP3R#P01064;Endothelin signaling pathway#P00019>IP3 R#P00590;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>IP3R#P00842;Histamine H1 receptor mediated signaling pathway#P04385>IP3R#P04486;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>IP3 channel#P00735;Gonadotropin-releasing hormone receptor pathway#P06664>IP3R#P06768;PDGF signaling pathway#P00047>IP3 receptor#P01160;B cell activation#P00010>IP3R#P00398 HUMAN|HGNC=8088|UniProtKB=Q9Y6K5 Q9Y6K5 OAS3 PTHR11258:SF4 2-5 OLIGOADENYLATE SYNTHETASE 2'-5'-OLIGOADENYLATE SYNTHASE 3 binding#GO:0005488;nucleic acid binding#GO:0003676;adenylyltransferase activity#GO:0070566;double-stranded RNA binding#GO:0003725;RNA binding#GO:0003723;catalytic activity#GO:0003824;transferase activity#GO:0016740;nucleotidyltransferase activity#GO:0016779;transferase activity, transferring phosphorus-containing groups#GO:0016772 innate immune response#GO:0045087;response to external stimulus#GO:0009605;defense response#GO:0006952;biological regulation#GO:0065007;response to other organism#GO:0051707;immune response#GO:0006955;cell communication#GO:0007154;response to virus#GO:0009615;cytokine-mediated signaling pathway#GO:0019221;regulation of cellular process#GO:0050794;response to external biotic stimulus#GO:0043207;cellular response to stimulus#GO:0051716;antiviral innate immune response#GO:0140374;cell surface receptor signaling pathway#GO:0007166;response to cytokine#GO:0034097;response to chemical#GO:0042221;defense response to other organism#GO:0098542;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;signal transduction#GO:0007165;defense response to symbiont#GO:0140546;cellular process#GO:0009987;response to peptide#GO:1901652;immune system process#GO:0002376;type I interferon-mediated signaling pathway#GO:0060337;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052;negative regulation of biological process#GO:0048519;defense response to virus#GO:0051607;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;cytosol#GO:0005829;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981 nucleotidyltransferase#PC00174;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=12628|UniProtKB=P45974 P45974 USP5 PTHR24006:SF655 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 5 cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;cysteine-type deubiquitinase activity#GO:0004843;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787 regulation of protein stability#GO:0031647;regulation of biological quality#GO:0065008;biological regulation#GO:0065007 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;cytosol#GO:0005829 protease#PC00190;cysteine protease#PC00081 HUMAN|HGNC=14874|UniProtKB=Q96PH1 Q96PH1 NOX5 PTHR11972:SF58 NADPH OXIDASE NADPH OXIDASE 5 oxidoreductase activity, acting on NAD(P)H#GO:0016651;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor#GO:0050664;catalytic activity#GO:0003824 cellular process#GO:0009987;metabolic process#GO:0008152;reactive oxygen species metabolic process#GO:0072593;response to stress#GO:0006950;defense response#GO:0006952;superoxide metabolic process#GO:0006801;response to stimulus#GO:0050896 plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane protein complex#GO:0098796;membrane#GO:0016020;oxidoreductase complex#GO:1990204;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494 oxidase#PC00175;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=28736|UniProtKB=Q86UF4 Q86UF4 CCDC190 PTHR36871:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 190 COILED-COIL DOMAIN-CONTAINING PROTEIN 190 HUMAN|HGNC=16519|UniProtKB=Q9BZG1 Q9BZG1 RAB34 PTHR47977:SF8 RAS-RELATED PROTEIN RAB RAS-RELATED PROTEIN RAB-34 nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;ion binding#GO:0043167;GTPase activity#GO:0003924;anion binding#GO:0043168;small molecule binding#GO:0036094;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;guanyl nucleotide binding#GO:0019001 membrane organization#GO:0061024;membrane fusion#GO:0061025;macromolecule localization#GO:0033036;vesicle-mediated transport to the plasma membrane#GO:0098876;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;transport#GO:0006810;lytic vacuole organization#GO:0080171;phagocytosis#GO:0006909;vesicle fusion#GO:0006906;Golgi to plasma membrane transport#GO:0006893;protein localization to plasma membrane#GO:0072659;vacuole organization#GO:0007033;localization#GO:0051179;establishment of protein localization to plasma membrane#GO:0061951;localization within membrane#GO:0051668;organelle assembly#GO:0070925;organelle membrane fusion#GO:0090174;organelle fusion#GO:0048284;cellular component assembly#GO:0022607;vesicle-mediated transport#GO:0016192;establishment of protein localization#GO:0045184;cellular process#GO:0009987;lysosome organization#GO:0007040;cellular component biogenesis#GO:0044085;establishment of protein localization to membrane#GO:0090150;organelle organization#GO:0006996;vesicle organization#GO:0016050;cellular component organization or biogenesis#GO:0071840;import into cell#GO:0098657;Golgi vesicle transport#GO:0048193;phagolysosome assembly#GO:0001845;protein localization to cell periphery#GO:1990778;Golgi to plasma membrane protein transport#GO:0043001;endocytosis#GO:0006897;protein localization to membrane#GO:0072657;cellular component organization#GO:0016043;post-Golgi vesicle-mediated transport#GO:0006892;protein transport#GO:0015031;cellular localization#GO:0051641 intracellular vesicle#GO:0097708;vesicle#GO:0031982;Golgi stack#GO:0005795;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;endocytic vesicle#GO:0030139;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;Golgi apparatus subcompartment#GO:0098791;Golgi cisterna#GO:0031985;phagocytic vesicle#GO:0045335;endomembrane system#GO:0012505;cytoplasm#GO:0005737;Golgi apparatus#GO:0005794 small GTPase#PC00208 HUMAN|HGNC=33494|UniProtKB=Q5H943 Q5H943 CT83 PTHR38650:SF1 KITA-KYUSHU LUNG CANCER ANTIGEN 1 KITA-KYUSHU LUNG CANCER ANTIGEN 1 HUMAN|HGNC=5479|UniProtKB=P01877 P01877 IGHA2 PTHR23411:SF31 TAPASIN IMMUNOGLOBULIN HEAVY CONSTANT ALPHA 1-RELATED antigen binding#GO:0003823;signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515 response to external biotic stimulus#GO:0043207;regulation of immune system process#GO:0002682;regulation of immune response#GO:0050776;response to bacterium#GO:0009617;immune response#GO:0006955;complement activation#GO:0006956;adaptive immune response#GO:0002250;response to other organism#GO:0051707;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;defense response#GO:0006952;response to external stimulus#GO:0009605;regulation of biological process#GO:0050789;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;defense response to bacterium#GO:0042742;immune system process#GO:0002376;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;activation of immune response#GO:0002253;positive regulation of biological process#GO:0048518;defense response to symbiont#GO:0140546;response to stress#GO:0006950;positive regulation of immune system process#GO:0002684;response to biotic stimulus#GO:0009607;defense response to other organism#GO:0098542;immune effector process#GO:0002252;humoral immune response#GO:0006959;antimicrobial humoral response#GO:0019730;antibacterial humoral response#GO:0019731 extracellular protein-containing complex#GO:0140392;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=14198|UniProtKB=Q9BQ52 Q9BQ52 ELAC2 PTHR12553:SF49 ZINC PHOSPHODIESTERASE ELAC PROTEIN 2 ZINC PHOSPHODIESTERASE ELAC PROTEIN 2 catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity, acting on ester bonds#GO:0016788;RNA endonuclease activity#GO:0004521;catalytic activity, acting on RNA#GO:0140098;endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;hydrolase activity#GO:0016787;catalytic activity, acting on a tRNA#GO:0140101;nuclease activity#GO:0004518 nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;tRNA processing#GO:0008033;RNA 3'-end processing#GO:0031123;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;mitochondrial RNA processing#GO:0000963;cellular process#GO:0009987;gene expression#GO:0010467;mitochondrial RNA 3'-end processing#GO:0000965;tRNA 3'-end processing#GO:0042780;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;mitochondrial RNA metabolic process#GO:0000959;mitochondrial gene expression#GO:0140053;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774 mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 phosphodiesterase#PC00185 HUMAN|HGNC=14189|UniProtKB=O00453 O00453 LST1 PTHR15452:SF5 LEUKOCYTE-SPECIFIC TRANSCRIPT 1 PROTEIN LEUKOCYTE-SPECIFIC TRANSCRIPT 1 PROTEIN neuron differentiation#GO:0030182;developmental process#GO:0032502;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;neuron projection development#GO:0031175;plasma membrane bounded cell projection organization#GO:0120036;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;neuron development#GO:0048666;system development#GO:0048731;anatomical structure development#GO:0048856;dendrite development#GO:0016358;cellular component organization#GO:0016043;cell development#GO:0048468;cell projection organization#GO:0030030;cell differentiation#GO:0030154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=7010|UniProtKB=O00255 O00255 MEN1 PTHR12693:SF3 MENIN MENIN sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;chromatin binding#GO:0003682;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 response to stress#GO:0006950;transcription initiation at RNA polymerase II promoter#GO:0006367;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;gene expression#GO:0010467;positive regulation of macromolecule metabolic process#GO:0010604;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;transcription initiation-coupled chromatin remodeling#GO:0045815;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;DNA-templated transcription initiation#GO:0006352;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;chromatin remodeling#GO:0006338;nucleic acid biosynthetic process#GO:0141187;cellular response to stress#GO:0033554;RNA metabolic process#GO:0016070;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of macromolecule biosynthetic process#GO:0010556;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;macromolecule biosynthetic process#GO:0009059;positive regulation of cellular process#GO:0048522;regulation of nucleobase-containing compound metabolic process#GO:0019219;biosynthetic process#GO:0009058;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;chromatin organization#GO:0006325;regulation of RNA biosynthetic process#GO:2001141;DNA damage response#GO:0006974;transcription by RNA polymerase II#GO:0006366;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulation of gene expression#GO:0010468;positive regulation of gene expression#GO:0010628;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252 histone methyltransferase complex#GO:0035097;transferase complex#GO:1990234;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;chromatin#GO:0000785;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;methyltransferase complex#GO:0034708 CCKR signaling map#P06959>MEN1#P07084 HUMAN|HGNC=10932|UniProtKB=Q9Y2C5 Q9Y2C5 SLC17A4 PTHR11662:SF284 SOLUTE CARRIER FAMILY 17 SMALL INTESTINE URATE EXPORTER-RELATED transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 establishment of localization#GO:0051234;localization#GO:0051179;phosphate ion transport#GO:0006817;inorganic anion transport#GO:0015698;transport#GO:0006810 plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;apical plasma membrane#GO:0016324;membrane#GO:0016020;apical part of cell#GO:0045177;cell periphery#GO:0071944 secondary carrier transporter#PC00258 HUMAN|HGNC=2334|UniProtKB=P17927 P17927 CR1 PTHR19325:SF545 COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING COMPLEMENT RECEPTOR TYPE 1 regulation of response to stimulus#GO:0048583;immune effector process#GO:0002252;immune response#GO:0006955;adaptive immune response#GO:0002250;biological regulation#GO:0065007;negative regulation of immune system process#GO:0002683;negative regulation of response to stimulus#GO:0048585;regulation of immune response#GO:0050776;T cell mediated immunity#GO:0002456;negative regulation of immune response#GO:0050777;immune system process#GO:0002376;regulation of lymphocyte mediated immunity#GO:0002706;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;regulation of immune effector process#GO:0002697;regulation of leukocyte mediated immunity#GO:0002703;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of immune system process#GO:0002682;response to stimulus#GO:0050896 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;cell periphery#GO:0071944;membrane#GO:0016020 defense/immunity protein#PC00090;complement component#PC00078 HUMAN|HGNC=9959|UniProtKB=P51606 P51606 RENBP PTHR15108:SF0 N-ACYLGLUCOSAMINE-2-EPIMERASE N-ACYLGLUCOSAMINE 2-EPIMERASE isomerase activity#GO:0016853;racemase and epimerase activity#GO:0016854;catalytic activity#GO:0003824;racemase and epimerase activity, acting on carbohydrates and derivatives#GO:0016857 epimerase/racemase#PC00096 HUMAN|HGNC=23987|UniProtKB=Q9UI09 Q9UI09 NDUFA12 PTHR12910:SF2 NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B17.2 NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 12 catalytic complex#GO:1902494;respiratory chain complex I#GO:0045271;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;membrane protein complex#GO:0098796;membrane#GO:0016020;oxidoreductase complex#GO:1990204;respiratory chain complex#GO:0098803;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=27393|UniProtKB=Q5TGY1 Q5TGY1 TMCO4 PTHR17920:SF3 TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4 TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 HUMAN|HGNC=14967|UniProtKB=Q9HBV2 Q9HBV2 SPACA1 PTHR47223:SF1 SPERM ACROSOME MEMBRANE-ASSOCIATED PROTEIN 1 SPERM ACROSOME MEMBRANE-ASSOCIATED PROTEIN 1 vesicle organization#GO:0016050;anatomical structure formation involved in morphogenesis#GO:0048646;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;spermatogenesis#GO:0007283;developmental process#GO:0032502;cellular anatomical entity morphogenesis#GO:0032989;endomembrane system organization#GO:0010256;male gamete generation#GO:0048232;cellular component assembly#GO:0022607;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;multicellular organismal reproductive process#GO:0048609;anatomical structure development#GO:0048856;spermatid development#GO:0007286;acrosome assembly#GO:0001675;sexual reproduction#GO:0019953;cellular component assembly involved in morphogenesis#GO:0010927;spermatid differentiation#GO:0048515;organelle assembly#GO:0070925;cell development#GO:0048468;reproductive process#GO:0022414;cellular process involved in reproduction in multicellular organism#GO:0022412;gamete generation#GO:0007276;cell differentiation#GO:0030154;germ cell development#GO:0007281;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;developmental process involved in reproduction#GO:0003006 intracellular organelle#GO:0043229;acrosomal vesicle#GO:0001669;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;vesicle#GO:0031982;intracellular vesicle#GO:0097708;secretory granule membrane#GO:0030667;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;acrosomal membrane#GO:0002080;secretory vesicle#GO:0099503;membrane#GO:0016020;vesicle membrane#GO:0012506;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659 HUMAN|HGNC=28055|UniProtKB=Q86UD0 Q86UD0 SAPCD2 PTHR14907:SF3 FI14130P SUPPRESSOR APC DOMAIN-CONTAINING PROTEIN 2 HUMAN|HGNC=18859|UniProtKB=Q9NRA0 Q9NRA0 SPHK2 PTHR12358:SF40 SPHINGOSINE KINASE SPHINGOSINE KINASE 2 lipid kinase activity#GO:0001727;phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824 lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;regulation of apoptotic process#GO:0042981;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;alcohol metabolic process#GO:0006066;sphingolipid biosynthetic process#GO:0030148;positive regulation of apoptotic process#GO:0043065;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;alcohol biosynthetic process#GO:0046165;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;biological regulation#GO:0065007;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;sphingoid biosynthetic process#GO:0046520;organophosphate biosynthetic process#GO:0090407;regulation of biological process#GO:0050789;regulation of programmed cell death#GO:0043067;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phospholipid metabolic process#GO:0006644;small molecule metabolic process#GO:0044281;phospholipid biosynthetic process#GO:0008654;regulation of cellular process#GO:0050794;positive regulation of programmed cell death#GO:0043068 transferase#PC00220;kinase#PC00137;metabolite interconversion enzyme#PC00262 Angiogenesis#P00005>SPK#P00229;VEGF signaling pathway#P00056>SPK#P01404 HUMAN|HGNC=9636|UniProtKB=O75365 O75365 PTP4A3 PTHR23339:SF119 TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE PROTEIN TYROSINE PHOSPHATASE TYPE IVA 3 catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725;phosphoprotein phosphatase activity#GO:0004721 cell motility#GO:0048870;cell migration#GO:0016477;endothelial cell migration#GO:0043542;cellular process#GO:0009987 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 protein modifying enzyme#PC00260;protein phosphatase#PC00195 HUMAN|HGNC=17493|UniProtKB=O75496 O75496 GMNN PTHR13372:SF4 GEMININ GEMININ transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of DNA replication#GO:0006275;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of DNA metabolic process#GO:0051052;regulation of DNA-templated DNA replication#GO:0090329;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;regulation of cell cycle#GO:0051726;negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cell cycle#GO:0045786;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated DNA replication initiation#GO:0030174 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;transcription repressor complex#GO:0017053;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634 HUMAN|HGNC=10984|UniProtKB=O95258 O95258 SLC25A14 PTHR45618:SF20 MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED BRAIN MITOCHONDRIAL CARRIER PROTEIN 1 monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic anion transmembrane transporter activity#GO:0008509;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;proton transmembrane transporter activity#GO:0015078;chloride transmembrane transporter activity#GO:0015108 biological regulation#GO:0065007;regulation of cellular response to stress#GO:0080135;regulation of cellular process#GO:0050794;regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;regulation of response to stress#GO:0080134 membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;organelle envelope#GO:0031967;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227 secondary carrier transporter#PC00258;transporter#PC00227 HUMAN|HGNC=1919|UniProtKB=Q14839 Q14839 CHD4 PTHR45623:SF22 CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED ATP-DEPENDENT CHROMATIN REMODELER CHD4 protein binding#GO:0005515;ATP-dependent activity, acting on DNA#GO:0008094;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;ATP-dependent activity#GO:0140657;catalytic activity, acting on DNA#GO:0140097;hydrolase activity, acting on acid anhydrides#GO:0016817;DNA binding#GO:0003677;hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887;nucleic acid binding#GO:0003676;chromatin binding#GO:0003682;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;pyrophosphatase activity#GO:0016462;histone binding#GO:0042393 cellular component organization or biogenesis#GO:0071840;chromatin organization#GO:0006325;chromatin remodeling#GO:0006338;cellular component organization#GO:0016043;cellular process#GO:0009987 chromosome#GO:0005694;chromatin#GO:0000785;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=19097|UniProtKB=Q93062 Q93062 RBPMS PTHR10501:SF25 U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B RNA-BINDING PROTEIN WITH MULTIPLE SPLICING RNA binding#GO:0003723;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488 RNA metabolism protein#PC00031;RNA splicing factor#PC00148;RNA processing factor#PC00147 HUMAN|HGNC=8208|UniProtKB=Q8NGS3 Q8NGS3 OR1J1 PTHR48001:SF148 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 1J1 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell communication#GO:0007154 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=13780|UniProtKB=Q96RP9 Q96RP9 GFM1 PTHR43636:SF2 ELONGATION FACTOR G, MITOCHONDRIAL ELONGATION FACTOR G, MITOCHONDRIAL translation factor activity#GO:0180051;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;translation elongation factor activity#GO:0003746;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924;hydrolase activity#GO:0016787 mitochondrial gene expression#GO:0140053;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;translation#GO:0006412;translational elongation#GO:0006414;metabolic process#GO:0008152;biosynthetic process#GO:0009058;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;mitochondrial translation#GO:0032543;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238 mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=7516|UniProtKB=Q9HC84 Q9HC84 MUC5B PTHR11339:SF408 EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED MUCIN-5B structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical structure#GO:0110165 extracellular matrix protein#PC00102 HUMAN|HGNC=21719|UniProtKB=Q01449 Q01449 MYL7 PTHR23049:SF39 MYOSIN REGULATORY LIGHT CHAIN 2 MYOSIN REGULATORY LIGHT CHAIN 2, ATRIAL ISOFORM cation binding#GO:0043169;protein binding#GO:0005515;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;myosin binding#GO:0017022 multicellular organismal process#GO:0032501;tissue development#GO:0009888;heart development#GO:0007507;blood circulation#GO:0008015;animal organ development#GO:0048513;cardiac muscle tissue development#GO:0048738;multicellular organism development#GO:0007275;system process#GO:0003008;heart contraction#GO:0060047;developmental process#GO:0032502;striated muscle tissue development#GO:0014706;circulatory system development#GO:0072359;heart process#GO:0003015;anatomical structure development#GO:0048856;system development#GO:0048731;muscle tissue development#GO:0060537;circulatory system process#GO:0003013;animal gross anatomical part developmental process#GO:0160108 organelle#GO:0043226;cellular anatomical structure#GO:0110165;actin cytoskeleton#GO:0015629;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;myofibril#GO:0030016;intracellular organelle#GO:0043229;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;contractile muscle fiber#GO:0043292;myosin complex#GO:0016459;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856 actin or actin-binding cytoskeletal protein#PC00041;cytoskeletal protein#PC00085 HUMAN|HGNC=5253|UniProtKB=P07900 P07900 HSP90AA1 PTHR11528:SF87 HEAT SHOCK PROTEIN 90 FAMILY MEMBER HEAT SHOCK PROTEIN HSP 90-ALPHA ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;ATP hydrolysis activity#GO:0016887;hydrolase activity#GO:0016787;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;ATP-dependent activity#GO:0140657;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP binding#GO:0005524;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363 response to stress#GO:0006950;cellular response to heat#GO:0034605;response to heat#GO:0009408;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;regulation of protein stability#GO:0031647;gene expression#GO:0010467;protein maturation#GO:0051604;response to temperature stimulus#GO:0009266;biosynthetic process#GO:0009058;biological regulation#GO:0065007;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein stabilization#GO:0050821;primary metabolic process#GO:0044238;response to abiotic stimulus#GO:0009628;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;protein folding#GO:0006457;cellular response to stress#GO:0033554;protein metabolic process#GO:0019538;regulation of biological quality#GO:0065008 cytoplasm#GO:0005737;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;perinuclear region of cytoplasm#GO:0048471;myelin sheath#GO:0043209;membrane#GO:0016020;cytosol#GO:0005829;cell periphery#GO:0071944;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;neuronal cell body#GO:0043025;cell body#GO:0044297;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 chaperone#PC00072;Hsp90 family chaperone#PC00028 HUMAN|HGNC=23760|UniProtKB=Q9H6B9 Q9H6B9 EPHX3 PTHR43329:SF10 EPOXIDE HYDROLASE EPOXIDE HYDROLASE 3 ether hydrolase activity#GO:0016803;hydrolase activity#GO:0016787;catalytic activity#GO:0003824 cellular process#GO:0009987;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;primary metabolic process#GO:0044238 hydrolase#PC00121 HUMAN|HGNC=17180|UniProtKB=Q8WWX0 Q8WWX0 ASB5 PTHR24136:SF18 SOWAH (DROSOPHILA) HOMOLOG ANKYRIN REPEAT AND SOCS BOX PROTEIN 5 regulation of catabolic process#GO:0009894;macromolecule metabolic process#GO:0043170;positive regulation of catabolic process#GO:0009896;metabolic process#GO:0008152;biological regulation#GO:0065007;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;positive regulation of protein catabolic process#GO:0045732;regulation of protein catabolic process#GO:0042176;positive regulation of metabolic process#GO:0009893;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;positive regulation of protein metabolic process#GO:0051247;protein modification by small protein conjugation or removal#GO:0070647;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;protein modification process#GO:0036211 HUMAN|HGNC=27279|UniProtKB=Q6UWV2 Q6UWV2 MPZL3 PTHR13869:SF20 MYELIN P0 RELATED MYELIN PROTEIN ZERO-LIKE PROTEIN 3 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 myelin protein#PC00161 HUMAN|HGNC=26024|UniProtKB=Q9H9L4 Q9H9L4 KANSL2 PTHR13453:SF1 KAT8 REGULATORY NSL COMPLEX SUBUNIT 2 KAT8 REGULATORY NSL COMPLEX SUBUNIT 2 protein-containing complex#GO:0032991;H4 histone acetyltransferase complex#GO:1902562;intracellular membraneless organelle#GO:0043232;chromatin#GO:0000785;membraneless organelle#GO:0043228;intracellular protein-containing complex#GO:0140535;histone acetyltransferase complex#GO:0000123;transferase complex#GO:1990234;cellular anatomical structure#GO:0110165;organelle#GO:0043226;chromosome#GO:0005694;NSL complex#GO:0044545;intracellular anatomical structure#GO:0005622;acetyltransferase complex#GO:1902493;protein acetyltransferase complex#GO:0031248;intracellular organelle#GO:0043229;catalytic complex#GO:1902494 HUMAN|HGNC=6025|UniProtKB=P10145 P10145 CXCL8 PTHR12015:SF198 SMALL INDUCIBLE CYTOKINE A INTERLEUKIN-8 molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;G protein-coupled receptor binding#GO:0001664;chemokine activity#GO:0008009;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;molecular function activator activity#GO:0140677;chemokine receptor binding#GO:0042379;protein binding#GO:0005515;cytokine receptor binding#GO:0005126;signaling receptor binding#GO:0005102;binding#GO:0005488;cytokine activity#GO:0005125 myeloid leukocyte migration#GO:0097529;response to external stimulus#GO:0009605;defense response#GO:0006952;leukocyte chemotaxis#GO:0030595;cellular response to molecule of bacterial origin#GO:0071219;leukocyte migration#GO:0050900;response to other organism#GO:0051707;cell migration#GO:0016477;immune response#GO:0006955;cell chemotaxis#GO:0060326;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;inflammatory response#GO:0006954;chemotaxis#GO:0006935;response to bacterium#GO:0009617;response to external biotic stimulus#GO:0043207;locomotion#GO:0040011;cell motility#GO:0048870;cellular response to stimulus#GO:0051716;cellular response to biotic stimulus#GO:0071216;response to lipopolysaccharide#GO:0032496;neutrophil chemotaxis#GO:0030593;humoral immune response#GO:0006959;antimicrobial humoral response#GO:0019730;taxis#GO:0042330;neutrophil migration#GO:1990266;response to chemical#GO:0042221;cellular response to lipid#GO:0071396;response to lipid#GO:0033993;granulocyte migration#GO:0097530;defense response to other organism#GO:0098542;cellular response to oxygen-containing compound#GO:1901701;defense response to symbiont#GO:0140546;cellular process#GO:0009987;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;cellular response to lipopolysaccharide#GO:0071222;response to oxygen-containing compound#GO:1901700;immune system process#GO:0002376;cellular response to chemical stimulus#GO:0070887;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;granulocyte chemotaxis#GO:0071621;response to molecule of bacterial origin#GO:0002237 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 cytokine#PC00083 CCKR signaling map#P06959>IL8#G07296;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CHK#P00856;CCKR signaling map#P06959>IL8#G07001;CCKR signaling map#P06959>IL8#P07136;Interleukin signaling pathway#P00036>Interleukin#P00970 HUMAN|HGNC=23609|UniProtKB=Q9BXI6 Q9BXI6 TBC1D10A PTHR22957:SF215 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN TBC1 DOMAIN FAMILY MEMBER 10A nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme activator activity#GO:0008047 transport#GO:0006810;intracellular transport#GO:0046907;endosomal transport#GO:0016197;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;retrograde transport, endosome to Golgi#GO:0042147;cytosolic transport#GO:0016482;vesicle-mediated transport#GO:0016192 GTPase-activating protein#PC00257;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HUMAN|HGNC=7113|UniProtKB=Q9H000 Q9H000 MKRN2 PTHR11224:SF17 MAKORIN-RELATED E3 UBIQUITIN-PROTEIN LIGASE MAKORIN-2 ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;protein modification process#GO:0036211;primary metabolic process#GO:0044238;cellular process#GO:0009987;protein modification by small protein conjugation#GO:0032446 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=16286|UniProtKB=Q92556 Q92556 ELMO1 PTHR12771:SF23 ENGULFMENT AND CELL MOTILITY ENGULFMENT AND CELL MOTILITY PROTEIN 1 cellular component organization or biogenesis#GO:0071840;actin filament organization#GO:0007015;response to external stimulus#GO:0009605;cell migration#GO:0016477;response to chemical#GO:0042221;taxis#GO:0042330;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular process#GO:0009987;supramolecular fiber organization#GO:0097435;cell chemotaxis#GO:0060326;cellular response to chemical stimulus#GO:0070887;actin filament-based process#GO:0030029;chemotaxis#GO:0006935;cell motility#GO:0048870;actin cytoskeleton organization#GO:0030036;response to stimulus#GO:0050896;locomotion#GO:0040011;cellular component organization#GO:0016043;cellular response to stimulus#GO:0051716 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;guanyl-nucleotide exchange factor complex#GO:0032045;protein-containing complex#GO:0032991;intracellular protein-containing complex#GO:0140535;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 Integrin signalling pathway#P00034>ELMO#P00917 HUMAN|HGNC=11425|UniProtKB=P08842 P08842 STS PTHR42693:SF9 ARYLSULFATASE FAMILY MEMBER STERYL-SULFATASE hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 hydrolase#PC00121 HUMAN|HGNC=21549|UniProtKB=Q5T6X4 Q5T6X4 FAM162B PTHR13674:SF3 GROWTH AND TRANSFORMATION-DEPENDENT PROTEIN PROTEIN FAM162B HUMAN|HGNC=21118|UniProtKB=Q008S8 Q008S8 ECT2L PTHR46857:SF1 EPITHELIAL CELL-TRANSFORMING SEQUENCE 2 ONCOGENE-LIKE EPITHELIAL CELL-TRANSFORMING SEQUENCE 2 ONCOGENE-LIKE HUMAN|HGNC=3818|UniProtKB=Q08050 Q08050 FOXM1 PTHR46878:SF1 FORKHEAD BOX PROTEIN M1 FORKHEAD BOX PROTEIN M1 double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 positive regulation of double-strand break repair#GO:2000781;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;positive regulation of DNA metabolic process#GO:0051054;regulation of double-strand break repair#GO:2000779;intracellular signal transduction#GO:0035556;regulation of RNA metabolic process#GO:0051252;cell communication#GO:0007154;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of DNA repair#GO:0045739;positive regulation of response to stimulus#GO:0048584;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of cellular process#GO:0048522;regulation of mitotic cell cycle#GO:0007346;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;DNA damage response#GO:0006974;regulation of DNA repair#GO:0006282;regulation of response to stimulus#GO:0048583;regulation of response to stress#GO:0080134;regulation of cell cycle#GO:0051726;signaling#GO:0023052;response to stimulus#GO:0050896;signal transduction in response to DNA damage#GO:0042770;regulation of biological process#GO:0050789;regulation of DNA metabolic process#GO:0051052;regulation of cellular response to stress#GO:0080135;positive regulation of metabolic process#GO:0009893;cellular response to stress#GO:0033554;signal transduction by p53 class mediator#GO:0072331;positive regulation of macromolecule metabolic process#GO:0010604;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;response to stress#GO:0006950 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 winged helix/forkhead transcription factor#PC00246;DNA-binding transcription factor#PC00218 HUMAN|HGNC=24288|UniProtKB=Q8NE62 Q8NE62 CHDH PTHR11552:SF231 GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE CHOLINE DEHYDROGENASE, MITOCHONDRIAL oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HUMAN|HGNC=6003|UniProtKB=Q9UHF4 Q9UHF4 IL20RA PTHR20859:SF86 INTERFERON/INTERLEUKIN RECEPTOR INTERLEUKIN-20 RECEPTOR SUBUNIT ALPHA transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488;protein binding#GO:0005515;molecular transducer activity#GO:0060089;cytokine receptor activity#GO:0004896;signaling receptor activity#GO:0038023;cytokine binding#GO:0019955;immune receptor activity#GO:0140375 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;regulation of cellular process#GO:0050794;response to cytokine#GO:0034097;response to stimulus#GO:0050896;response to chemical#GO:0042221;biological regulation#GO:0065007;signaling#GO:0023052;cytokine-mediated signaling pathway#GO:0019221;cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;response to peptide#GO:1901652 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 Interleukin signaling pathway#P00036>Receptor subunit alpha#P00992 HUMAN|HGNC=26809|UniProtKB=Q6XPR3 Q6XPR3 RPTN PTHR14054:SF14 REPETIN REPETIN plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=20045|UniProtKB=Q9H840 Q9H840 GEMIN7 PTHR14679:SF1 GEM-ASSOCIATED PROTEIN 7 GEM-ASSOCIATED PROTEIN 7 RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;ribonucleoprotein complex biogenesis#GO:0022613;spliceosomal snRNP assembly#GO:0000387;mRNA splicing, via spliceosome#GO:0000398;protein-containing complex assembly#GO:0065003;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;protein-RNA complex assembly#GO:0022618;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;cellular component assembly#GO:0022607;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;cellular component biogenesis#GO:0044085;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-RNA complex organization#GO:0071826;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654 protein-containing complex#GO:0032991;Sm-like protein family complex#GO:0120114 HUMAN|HGNC=18821|UniProtKB=Q6XZB0 Q6XZB0 LIPI PTHR11610:SF103 LIPASE LIPASE MEMBER I phospholipase activity#GO:0120569;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;lipase activity#GO:0016298;glycerophospholipase activity#GO:0004620;hydrolase activity#GO:0016787 catabolic process#GO:0009056;lipid catabolic process#GO:0016042;cellular process#GO:0009987;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;primary metabolic process#GO:0044238 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 hydrolase#PC00121;lipase#PC00143;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=282|UniProtKB=P18089 P18089 ADRA2B PTHR24248:SF130 ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR ALPHA-2B ADRENERGIC RECEPTOR G protein-coupled amine receptor activity#GO:0008227;hormone binding#GO:0042562;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;cation binding#GO:0043169;molecular transducer activity#GO:0060089 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway#GO:0007193;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cell communication#GO:0007154;adrenergic receptor signaling pathway#GO:0071875;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021 Alpha adrenergic receptor signaling pathway#P00002>Alpha1A/1B/1C#P00078;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711 HUMAN|HGNC=26368|UniProtKB=Q4G0Z9 Q4G0Z9 MCMDC2 PTHR11630:SF75 DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER MINICHROMOSOME MAINTENANCE DOMAIN-CONTAINING PROTEIN 2 DNA binding#GO:0003677;ATP-dependent activity, acting on DNA#GO:0008094;binding#GO:0005488;nucleic acid binding#GO:0003676;single-stranded DNA binding#GO:0003697;ATP-dependent activity#GO:0140657;catalytic activity, acting on DNA#GO:0140097;helicase activity#GO:0004386;isomerase activity#GO:0016853;DNA helicase activity#GO:0003678;catalytic activity#GO:0003824;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;macromolecular conformation isomerase activity#GO:0120543 nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;response to stress#GO:0006950;double-strand break repair via break-induced replication#GO:0000727;mitotic cell cycle process#GO:1903047;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;DNA replication initiation#GO:0006270;DNA recombination#GO:0006310;DNA damage response#GO:0006974;DNA repair#GO:0006281;cell cycle DNA replication#GO:0044786;metabolic process#GO:0008152;mitotic DNA replication#GO:1902969;DNA metabolic process#GO:0006259;nuclear DNA replication#GO:0033260;DNA strand elongation involved in DNA replication#GO:0006271;response to stimulus#GO:0050896;mitotic cell cycle#GO:0000278;double-strand break repair via homologous recombination#GO:0000724;cell cycle process#GO:0022402;cellular response to stimulus#GO:0051716;DNA replication#GO:0006260;cell cycle#GO:0007049;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;DNA-templated DNA replication#GO:0006261;cellular response to stress#GO:0033554;recombinational repair#GO:0000725 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;MCM complex#GO:0042555;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 DNA metabolism protein#PC00009 HUMAN|HGNC=6914|UniProtKB=P56270 P56270 MAZ PTHR24390:SF122 ZINC FINGER PROTEIN MYC-ASSOCIATED ZINC FINGER PROTEIN sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=24438|UniProtKB=Q8N2G8 Q8N2G8 GHDC PTHR31901:SF9 GH3 DOMAIN-CONTAINING PROTEIN GH3 DOMAIN-CONTAINING PROTEIN ligase activity, forming carbon-nitrogen bonds#GO:0016879;catalytic activity#GO:0003824;ligase activity#GO:0016874 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=14346|UniProtKB=Q9BXJ3 Q9BXJ3 C1QTNF4 PTHR22923:SF118 CEREBELLIN-RELATED COMPLEMENT C1Q TUMOR NECROSIS FACTOR-RELATED PROTEIN 4 regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;positive regulation of cytokine-mediated signaling pathway#GO:0001961;positive regulation of signaling#GO:0023056;regulation of biological process#GO:0050789;regulation of non-canonical NF-kappaB signal transduction#GO:1901222;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;regulation of cytokine-mediated signaling pathway#GO:0001959;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of response to cytokine stimulus#GO:0060759;positive regulation of non-canonical NF-kappaB signal transduction#GO:1901224;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of response to stimulus#GO:0048584 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=8104|UniProtKB=Q16625 Q16625 OCLN PTHR23288:SF4 OCCLUDIN AND RNA POLYMERASE II ELONGATION FACTOR ELL OCCLUDIN nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 cellular component organization#GO:0016043;cell junction assembly#GO:0034329;regulation of biological process#GO:0050789;positive regulation of DNA-templated transcription, elongation#GO:0032786;snRNA transcription#GO:0009301;regulation of transcription by RNA polymerase II#GO:0006357;regulation of DNA-templated transcription elongation#GO:0032784;nucleic acid biosynthetic process#GO:0141187;regulation of transcription elongation by RNA polymerase II#GO:0034243;RNA metabolic process#GO:0016070;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;gene expression#GO:0010467;cellular component assembly#GO:0022607;positive regulation of macromolecule metabolic process#GO:0010604;nucleobase-containing compound biosynthetic process#GO:0034654;positive regulation of transcription by RNA polymerase II#GO:0045944;metabolic process#GO:0008152;cell-cell junction assembly#GO:0007043;cellular component organization or biogenesis#GO:0071840;snRNA transcription by RNA polymerase II#GO:0042795;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cell junction organization#GO:0034330;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;regulation of DNA-templated transcription#GO:0006355;snRNA metabolic process#GO:0016073;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;macromolecule biosynthetic process#GO:0009059;positive regulation of cellular process#GO:0048522;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biosynthetic process#GO:0009058;positive regulation of RNA biosynthetic process#GO:1902680;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;cell-cell junction organization#GO:0045216;transcription by RNA polymerase II#GO:0006366;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulation of gene expression#GO:0010468 transcription elongation factor complex#GO:0008023;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;vesicle#GO:0031982;intracellular vesicle#GO:0097708;apical plasma membrane#GO:0016324;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;plasma membrane#GO:0005886;cytoplasm#GO:0005737;bicellular tight junction#GO:0005923;plasma membrane region#GO:0098590;protein-containing complex#GO:0032991;cell periphery#GO:0071944;nucleus#GO:0005634;cell-cell junction#GO:0005911;membrane-enclosed lumen#GO:0031974;membrane#GO:0016020;nuclear protein-containing complex#GO:0140513;cell junction#GO:0030054;tight junction#GO:0070160;apical part of cell#GO:0045177;apical junction complex#GO:0043296 general transcription factor#PC00259 HUMAN|HGNC=25572|UniProtKB=Q8N5G2 Q8N5G2 MACO1 PTHR13289:SF6 PROTEIN PHOSPHATASE 1-BINDING PROTEIN BIFOCAL MACOILIN protein binding#GO:0005515;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;microtubule binding#GO:0008017 response to external stimulus#GO:0009605;cell communication#GO:0007154;chemotaxis#GO:0006935;locomotion#GO:0040011;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;taxis#GO:0042330;response to chemical#GO:0042221;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789 nuclear membrane#GO:0031965;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;nuclear envelope#GO:0005635;cytoplasm#GO:0005737;endomembrane system#GO:0012505;nucleus#GO:0005634;membrane#GO:0016020;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;rough endoplasmic reticulum membrane#GO:0030867;rough endoplasmic reticulum#GO:0005791;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;organelle envelope#GO:0031967 transporter#PC00227 HUMAN|HGNC=27992|UniProtKB=Q86VE3 Q86VE3 SATL1 PTHR10545:SF63 DIAMINE N-ACETYLTRANSFERASE SPERMIDINE_SPERMINE N(1)-ACETYLTRANSFERASE-LIKE PROTEIN 1 cation binding#GO:0043169;binding#GO:0005488;small molecule binding#GO:0036094;acetyltransferase activity#GO:0016407;acyltransferase activity#GO:0016746;ion binding#GO:0043167;N-acetyltransferase activity#GO:0008080;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity#GO:0003824;transferase activity#GO:0016740 acetyltransferase#PC00038;transferase#PC00220 HUMAN|HGNC=10671|UniProtKB=Q86SQ7 Q86SQ7 SDCCAG8 PTHR34343:SF1 SEROLOGICALLY DEFINED COLON CANCER ANTIGEN 8 SEROLOGICALLY DEFINED COLON CANCER ANTIGEN 8 cellular developmental process#GO:0048869;neuron migration#GO:0001764;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;microtubule-based process#GO:0007017;neurogenesis#GO:0022008;anatomical structure formation involved in morphogenesis#GO:0048646;microtubule organizing center organization#GO:0031023;developmental process#GO:0032502;cell migration#GO:0016477;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;tube development#GO:0035295;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular process#GO:0009987;microtubule cytoskeleton organization#GO:0000226;anatomical structure development#GO:0048856;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;establishment or maintenance of cell polarity#GO:0007163;generation of neurons#GO:0048699;cell motility#GO:0048870;cell differentiation#GO:0030154;cellular component organization#GO:0016043;tube morphogenesis#GO:0035239;establishment of cell polarity#GO:0030010;anatomical structure morphogenesis#GO:0009653 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;microtubule organizing center#GO:0005815;centrosome#GO:0005813;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;centriole#GO:0005814;microtubule cytoskeleton#GO:0015630 HUMAN|HGNC=19916|UniProtKB=Q5T7B8 Q5T7B8 KIF24 PTHR47971:SF8 KINESIN-RELATED PROTEIN 6 KINESIN-LIKE PROTEIN KIF24 cytoskeletal motor activity#GO:0003774;isomerase activity#GO:0016853;microtubule motor activity#GO:0003777;catalytic activity#GO:0003824;polypeptide conformation or assembly isomerase activity#GO:0120544;ATP-dependent activity#GO:0140657;macromolecular conformation isomerase activity#GO:0120543 supramolecular fiber organization#GO:0097435;microtubule-based process#GO:0007017;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226;cellular component disassembly#GO:0022411;cellular process#GO:0009987;organelle organization#GO:0006996;microtubule polymerization or depolymerization#GO:0031109;cellular component organization#GO:0016043;protein-containing complex disassembly#GO:0032984;cytoskeleton organization#GO:0007010;protein depolymerization#GO:0051261;microtubule depolymerization#GO:0007019 microtubule#GO:0005874;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;supramolecular complex#GO:0099080;organelle#GO:0043226;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630 microtubule or microtubule-binding cytoskeletal protein#PC00157;microtubule binding motor protein#PC00156 HUMAN|HGNC=18902|UniProtKB=Q9BYQ2 Q9BYQ2 KRTAP9-4 PTHR23262:SF32 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 9-2-RELATED structural protein#PC00211 HUMAN|HGNC=21444|UniProtKB=Q9BT76 Q9BT76 UPK3B PTHR15446:SF20 UROPLAKIN III UROPLAKIN-3B cellular anatomical structure#GO:0110165;membrane#GO:0016020 HUMAN|HGNC=29288|UniProtKB=A2RU67 A2RU67 FAM234B PTHR21419:SF25 FAMILY NOT NAMED PROTEIN FAM234B HUMAN|HGNC=28751|UniProtKB=Q86Y78 Q86Y78 LYPD6 PTHR31171:SF0 LY6/PLAUR DOMAIN-CONTAINING PROTEIN 6 LY6_PLAUR DOMAIN-CONTAINING PROTEIN 6 signaling receptor regulator activity#GO:0030545;acetylcholine receptor regulator activity#GO:0030548;molecular function regulator activity#GO:0098772;neurotransmitter receptor regulator activity#GO:0099602 HUMAN|HGNC=25509|UniProtKB=Q9P2N2 Q9P2N2 ARHGAP28 PTHR14963:SF5 RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED RHO GTPASE-ACTIVATING PROTEIN 28 molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;enzyme activator activity#GO:0008047 regulation of anatomical structure size#GO:0090066;regulation of small GTPase mediated signal transduction#GO:0051056;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;regulation of actin cytoskeleton organization#GO:0032956;regulation of actin filament length#GO:0030832;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;regulation of biological quality#GO:0065008;regulation of biological process#GO:0050789;regulation of cellular component size#GO:0032535;regulation of organelle organization#GO:0033043;regulation of actin filament bundle assembly#GO:0032231;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;regulation of protein-containing complex assembly#GO:0043254;regulation of cellular component biogenesis#GO:0044087;regulation of cellular component organization#GO:0051128;regulation of response to stimulus#GO:0048583;regulation of actin filament-based process#GO:0032970;negative regulation of cellular process#GO:0048523;regulation of actin filament organization#GO:0110053;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of actin polymerization or depolymerization#GO:0008064;regulation of actin filament polymerization#GO:0030833;negative regulation of cytoskeleton organization#GO:0051494;regulation of supramolecular fiber organization#GO:1902903;negative regulation of organelle organization#GO:0010639;negative regulation of cellular component organization#GO:0051129;regulation of stress fiber assembly#GO:0051492;regulation of cell communication#GO:0010646;regulation of cytoskeleton organization#GO:0051493;regulation of protein polymerization#GO:0032271;negative regulation of supramolecular fiber organization#GO:1902904;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 GTPase-activating protein#PC00257;G-protein modulator#PC00022 HUMAN|HGNC=5998|UniProtKB=Q01638 Q01638 IL1RL1 PTHR11890:SF7 INTERLEUKIN-1 RECEPTOR FAMILY MEMBER INTERLEUKIN-1 RECEPTOR-LIKE 1 protein binding#GO:0005515;cytokine binding#GO:0019955;binding#GO:0005488 regulation of cellular process#GO:0050794;response to chemical#GO:0042221;response to stimulus#GO:0050896;response to cytokine#GO:0034097;biological regulation#GO:0065007;signaling#GO:0023052;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;cell communication#GO:0007154;response to peptide#GO:1901652;cytokine-mediated signaling pathway#GO:0019221;cell surface receptor signaling pathway#GO:0007166 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cell surface#GO:0009986;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=37260|UniProtKB=Q8N5G0 Q8N5G0 SMIM20 PTHR34923:SF1 SMALL INTEGRAL MEMBRANE PROTEIN 20 SMALL INTEGRAL MEMBRANE PROTEIN 20 respiratory chain complex IV assembly#GO:0008535;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;cytochrome complex assembly#GO:0017004;mitochondrial respiratory chain complex IV assembly#GO:0033617;mitochondrion organization#GO:0007005;mitochondrial respiratory chain complex assembly#GO:0033108;cellular component assembly#GO:0022607;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;mitochondrial inner membrane#GO:0005743;organelle envelope#GO:0031967;membrane#GO:0016020;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=19200|UniProtKB=Q7L190 Q7L190 DPPA4 PTHR16073:SF8 DCR DOMAIN-CONTAINING PROTEIN DEVELOPMENTAL PLURIPOTENCY-ASSOCIATED PROTEIN 4 binding#GO:0005488;chromatin binding#GO:0003682 developmental process#GO:0032502;multicellular organism development#GO:0007275;multicellular organismal process#GO:0032501;anatomical structure development#GO:0048856;system development#GO:0048731 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=12449|UniProtKB=O43914 O43914 TYROBP PTHR17554:SF2 TYRO PROTEIN TYROSINE KINASE-BINDING PROTEIN TYRO PROTEIN TYROSINE KINASE-BINDING PROTEIN signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515 regulation of cell killing#GO:0031341;immune system process#GO:0002376;positive regulation of multicellular organismal process#GO:0051240;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;leukocyte activation involved in immune response#GO:0002366;regulation of B cell proliferation#GO:0030888;regulation of leukocyte proliferation#GO:0070663;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of immune system process#GO:0002684;regulation of mononuclear cell proliferation#GO:0032944;negative regulation of leukocyte activation#GO:0002695;negative regulation of lymphocyte activation#GO:0051250;regulation of immune effector process#GO:0002697;positive regulation of lymphocyte activation#GO:0051251;regulation of cell population proliferation#GO:0042127;negative regulation of multicellular organismal process#GO:0051241;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of macromolecule metabolic process#GO:0060255;negative regulation of cellular process#GO:0048523;defense response#GO:0006952;regulation of biosynthetic process#GO:0009889;negative regulation of cell activation#GO:0050866;immune response#GO:0006955;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of cell population proliferation#GO:0008285;regulation of metabolic process#GO:0019222;regulation of cytokine production#GO:0001817;positive regulation of cell activation#GO:0050867;positive regulation of immune effector process#GO:0002699;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;negative regulation of immune system process#GO:0002683;regulation of lymphocyte proliferation#GO:0050670;multicellular organismal process#GO:0032501;positive regulation of cellular component organization#GO:0051130;cell activation involved in immune response#GO:0002263;regulation of cell activation#GO:0050865;negative regulation of gene expression#GO:0010629;regulation of leukocyte activation#GO:0002694;regulation of lymphocyte activation#GO:0051249;negative regulation of metabolic process#GO:0009892;positive regulation of leukocyte activation#GO:0002696;immune effector process#GO:0002252;regulation of B cell activation#GO:0050864;response to stress#GO:0006950;negative regulation of macromolecule biosynthetic process#GO:0010558;microglial cell activation#GO:0001774;regulation of multicellular organismal process#GO:0051239;myeloid leukocyte activation#GO:0002274;cell activation#GO:0001775;inflammatory response#GO:0006954;regulation of leukocyte mediated cytotoxicity#GO:0001910;regulation of leukocyte mediated immunity#GO:0002703;leukocyte activation#GO:0045321;positive regulation of leukocyte mediated immunity#GO:0002705;regulation of gene expression#GO:0010468;macrophage activation#GO:0042116;regulation of macromolecule biosynthetic process#GO:0010556 cellular anatomical structure#GO:0110165;cell surface#GO:0009986 scaffold/adaptor protein#PC00226 HUMAN|HGNC=27867|UniProtKB=P0C1H6 P0C1H6 H2BW2 PTHR23428:SF380 HISTONE H2B HISTONE H2B TYPE F-M humoral immune response#GO:0006959;antimicrobial humoral response#GO:0019730;defense response#GO:0006952;response to external stimulus#GO:0009605;innate immune response#GO:0045087;antibacterial humoral response#GO:0019731;immune response#GO:0006955;defense response to symbiont#GO:0140546;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;response to other organism#GO:0051707;defense response to other organism#GO:0098542;defense response to bacterium#GO:0042742;response to bacterium#GO:0009617;immune system process#GO:0002376;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to stimulus#GO:0050896 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=30347|UniProtKB=Q9NVU0 Q9NVU0 POLR3E PTHR12069:SF0 DNA-DIRECTED RNA POLYMERASES III 80 KDA POLYPEPTIDE RNA POLYMERASE III SUBUNIT 5 DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5 nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;protein-containing complex#GO:0032991;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;RNA polymerase III complex#GO:0005666;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 DNA-directed RNA polymerase#PC00019 HUMAN|HGNC=11891|UniProtKB=P05452 P05452 CLEC3B PTHR22799:SF3 TETRANECTIN-RELATED TETRANECTIN animal organ development#GO:0048513;anatomical structure development#GO:0048856;developmental process#GO:0032502;biomineral tissue development#GO:0031214;animal gross anatomical part developmental process#GO:0160108;bone mineralization#GO:0030282;multicellular organismal process#GO:0032501;tissue development#GO:0009888;ossification#GO:0001503 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HUMAN|HGNC=18073|UniProtKB=Q9P291 Q9P291 ARMCX1 PTHR15712:SF14 ARMADILLO REPEAT CONTAINING PROTEIN ARMADILLO REPEAT-CONTAINING X-LINKED PROTEIN 1 microtubule-based movement#GO:0007018;establishment of organelle localization#GO:0051656;microtubule-based transport#GO:0099111;organelle localization#GO:0051640;axonal transport#GO:0098930;cellular localization#GO:0051641;localization#GO:0051179;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;axo-dendritic transport#GO:0008088;organelle transport along microtubule#GO:0072384;cytoskeleton-dependent intracellular transport#GO:0030705;transport#GO:0006810;intracellular transport#GO:0046907;mitochondrion localization#GO:0051646;microtubule-based process#GO:0007017;establishment of localization#GO:0051234;transport along microtubule#GO:0010970 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 scaffold/adaptor protein#PC00226 HUMAN|HGNC=4030|UniProtKB=Q9H0Q3 Q9H0Q3 FXYD6 PTHR14132:SF15 SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT GAMMA FXYD DOMAIN-CONTAINING ION TRANSPORT REGULATOR 6-RELATED transporter regulator activity#GO:0141108;ion channel regulator activity#GO:0099106;molecular function regulator activity#GO:0098772;channel regulator activity#GO:0016247 regulation of cellular process#GO:0050794;regulation of metal ion transport#GO:0010959;regulation of monoatomic ion transport#GO:0043269;biological regulation#GO:0065007;regulation of transmembrane transport#GO:0034762;regulation of monoatomic ion transmembrane transport#GO:0034765;regulation of biological process#GO:0050789;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of transport#GO:0051050;regulation of transport#GO:0051049;regulation of localization#GO:0032879;regulation of monoatomic cation transmembrane transport#GO:1904062 transporter#PC00227;primary active transporter#PC00068 HUMAN|HGNC=13067|UniProtKB=Q14593 Q14593 ZNF273 PTHR24384:SF201 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED ZINC FINGER PROTEIN 100-RELATED transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA-binding transcription factor#PC00218 HUMAN|HGNC=10396|UniProtKB=P62249 P62249 RPS16 PTHR21569:SF41 RIBOSOMAL PROTEIN S9 SMALL RIBOSOMAL SUBUNIT PROTEIN US9 RNA binding#GO:0003723;structural molecule activity#GO:0005198;nucleic acid binding#GO:0003676;binding#GO:0005488;structural constituent of ribosome#GO:0003735 RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;maturation of SSU-rRNA#GO:0030490;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;ribosomal small subunit biogenesis#GO:0042274;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytosolic ribosome#GO:0022626;cytosol#GO:0005829;ribosome#GO:0005840;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytosolic small ribosomal subunit#GO:0022627;ribonucleoprotein complex#GO:1990904;small ribosomal subunit#GO:0015935;intracellular organelle#GO:0043229 ribosomal protein#PC00202 HUMAN|HGNC=23798|UniProtKB=Q8TD91 Q8TD91 MAGEC3 PTHR11736:SF86 MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN MELANOMA-ASSOCIATED ANTIGEN C3 negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=12647|UniProtKB=Q9BV40 Q9BV40 VAMP8 PTHR45701:SF7 SYNAPTOBREVIN FAMILY MEMBER VESICLE-ASSOCIATED MEMBRANE PROTEIN 8 binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;SNARE binding#GO:0000149;SNAP receptor activity#GO:0005484;syntaxin binding#GO:0019905;protein binding#GO:0005515 localization#GO:0051179;secretion#GO:0046903;regulation of biological quality#GO:0065008;regulation of body fluid levels#GO:0050878;vesicle fusion#GO:0006906;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;vesicle organization#GO:0016050;protein-containing complex organization#GO:0043933;transport#GO:0006810;cellular component assembly#GO:0022607;organelle fusion#GO:0048284;vesicle-mediated transport#GO:0016192;multicellular organismal process#GO:0032501;membrane organization#GO:0061024;biological regulation#GO:0065007;organelle membrane fusion#GO:0090174;organelle organization#GO:0006996;membrane fusion#GO:0061025;cellular component biogenesis#GO:0044085;cellular process#GO:0009987 membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;vesicle#GO:0031982;SNARE complex#GO:0031201;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;secretory vesicle#GO:0099503;cell periphery#GO:0071944;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;plasma membrane#GO:0005886 membrane traffic protein#PC00150 Opioid proenkephalin pathway#P05915>SNARE Complex#P05986;5HT2 type receptor mediated signaling pathway#P04374>SNARE Complex#P04415;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>SNARE Complex#P01079;5HT4 type receptor mediated signaling pathway#P04376>SNARE Complex#P04428;Beta1 adrenergic receptor signaling pathway#P04377>SNARE Complex#P04435;Dopamine receptor mediated signaling pathway#P05912>SNARE Complex#P05956;Beta2 adrenergic receptor signaling pathway#P04378>SNARE Complex#P04442;Beta3 adrenergic receptor signaling pathway#P04379>SNARE Complex#P04447;Opioid prodynorphin pathway#P05916>SNARE Complex#P05996;5HT3 type receptor mediated signaling pathway#P04375>SNARE Complex#P04423;Opioid proopiomelanocortin pathway#P05917>SNARE Complex#P06005;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>SNARE Complex#P01066;Metabotropic glutamate receptor group II pathway#P00040>SNARE Complex#P01049;Ionotropic glutamate receptor pathway#P00037>SNARE Complex#P01013;Nicotinic acetylcholine receptor signaling pathway#P00044>SNARE Complex#P01091;Cortocotropin releasing factor receptor signaling pathway#P04380>SNARE Complex#P04457;Metabotropic glutamate receptor group III pathway#P00039>SNARE Complex#P01042;Thyrotropin-releasing hormone receptor signaling pathway#P04394>SNARE Complex#P04582;Oxytocin receptor mediated signaling pathway#P04391>SNARE Complex#P04532 HUMAN|HGNC=3778|UniProtKB=P02751 P02751 FN1 PTHR46708:SF8 TENASCIN FIBRONECTIN protein binding#GO:0005515;integrin binding#GO:0005178;protein-containing complex binding#GO:0044877;carbohydrate derivative binding#GO:0097367;binding#GO:0005488;signaling receptor binding#GO:0005102;cell adhesion molecule binding#GO:0050839 cellular process#GO:0009987;cellular component biogenesis#GO:0044085;nervous system development#GO:0007399;heart development#GO:0007507;cellular component assembly#GO:0022607;multicellular organismal process#GO:0032501;cell-substrate junction organization#GO:0150115;developmental process#GO:0032502;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;animal organ development#GO:0048513;cell-substrate junction assembly#GO:0007044;cell junction assembly#GO:0034329;cellular component organization#GO:0016043;circulatory system development#GO:0072359;cell junction organization#GO:0034330;cell-matrix adhesion#GO:0007160;cell adhesion#GO:0007155;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;cell-substrate adhesion#GO:0031589;anatomical structure development#GO:0048856 extracellular matrix protein#PC00102 Integrin signalling pathway#P00034>Fibronectin#P00939 HUMAN|HGNC=3625|UniProtKB=O75636 O75636 FCN3 PTHR19143:SF444 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FICOLIN-3 cellular anatomical structure#GO:0110165;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HUMAN|HGNC=24864|UniProtKB=O14556 O14556 GAPDHS PTHR10836:SF79 GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE, TESTIS-SPECIFIC glyceraldehyde-3-phosphate dehydrogenase (phosphorylating, [NAD(P)+] ) activity#GO:0043891;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor#GO:0016620;catalytic activity#GO:0003824;oxidoreductase activity, acting on the aldehyde or oxo group of donors#GO:0016903 monocarboxylic acid metabolic process#GO:0032787;phosphorus metabolic process#GO:0006793;carboxylic acid metabolic process#GO:0019752;purine nucleotide metabolic process#GO:0006163;ribonucleoside diphosphate metabolic process#GO:0009185;pyridine-containing compound catabolic process#GO:0072526;purine-containing compound metabolic process#GO:0072521;small molecule metabolic process#GO:0044281;pyridine nucleotide catabolic process#GO:0019364;pyruvate metabolic process#GO:0006090;oxoacid metabolic process#GO:0043436;purine nucleoside diphosphate metabolic process#GO:0009135;ribonucleotide metabolic process#GO:0009259;nucleotide metabolic process#GO:0009117;carbohydrate catabolic process#GO:0016052;nicotinamide nucleotide metabolic process#GO:0046496;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;ATP metabolic process#GO:0046034;metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;ADP catabolic process#GO:0046032;purine-containing compound catabolic process#GO:0072523;nucleobase-containing small molecule metabolic process#GO:0055086;purine nucleoside diphosphate catabolic process#GO:0009137;primary metabolic process#GO:0044238;purine ribonucleotide catabolic process#GO:0009154;purine nucleoside triphosphate metabolic process#GO:0009144;nucleoside diphosphate catabolic process#GO:0009134;catabolic process#GO:0009056;nucleoside phosphate catabolic process#GO:1901292;carbohydrate metabolic process#GO:0005975;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate derivative catabolic process#GO:1901136;nucleoside phosphate metabolic process#GO:0006753;nucleoside diphosphate metabolic process#GO:0009132;pyridine-containing compound metabolic process#GO:0072524;purine nucleotide catabolic process#GO:0006195;organophosphate catabolic process#GO:0046434;ribonucleoside diphosphate catabolic process#GO:0009191;cellular respiration#GO:0045333;aerobic respiration#GO:0009060;purine ribonucleoside diphosphate catabolic process#GO:0009181;nucleobase-containing compound catabolic process#GO:0034655;organophosphate metabolic process#GO:0019637;ribonucleotide catabolic process#GO:0009261;carbohydrate derivative metabolic process#GO:1901135;purine ribonucleoside triphosphate metabolic process#GO:0009205;glycolytic process#GO:0006096;nucleobase-containing compound metabolic process#GO:0006139;nucleotide catabolic process#GO:0009166;generation of precursor metabolites and energy#GO:0006091;purine ribonucleoside diphosphate metabolic process#GO:0009179;ADP metabolic process#GO:0046031;energy derivation by oxidation of organic compounds#GO:0015980 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 dehydrogenase#PC00092 Huntington disease#P00029>GAPDH#P00810 HUMAN|HGNC=34423|UniProtKB=Q8WTX7 Q8WTX7 CASTOR1 PTHR31131:SF3 CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE CYTOSOLIC ARGININE SENSOR FOR MTORC1 SUBUNIT 1 amino acid binding#GO:0016597;ion binding#GO:0043167;small molecule binding#GO:0036094;carboxylic acid binding#GO:0031406;anion binding#GO:0043168;binding#GO:0005488;organic acid binding#GO:0043177;cation binding#GO:0043169 regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;negative regulation of TOR signaling#GO:0032007;cellular response to amino acid stimulus#GO:0071230;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of cell communication#GO:0010648;response to nitrogen compound#GO:1901698;negative regulation of intracellular signal transduction#GO:1902532;regulation of signaling#GO:0023051;response to oxygen-containing compound#GO:1901700;regulation of intracellular signal transduction#GO:1902531;cellular response to chemical stimulus#GO:0070887;negative regulation of signaling#GO:0023057;negative regulation of signal transduction#GO:0009968;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of response to stimulus#GO:0048585;cellular response to nitrogen compound#GO:1901699;response to chemical#GO:0042221;regulation of TOR signaling#GO:0032006;cellular process#GO:0009987;response to acid chemical#GO:0001101;cellular response to oxygen-containing compound#GO:1901701;regulation of TORC1 signaling#GO:1903432;regulation of response to stimulus#GO:0048583;negative regulation of TORC1 signaling#GO:1904262;negative regulation of cellular process#GO:0048523 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=7506|UniProtKB=O75431 O75431 MTX2 PTHR12289:SF38 METAXIN RELATED METAXIN-2 protein localization to organelle#GO:0033365;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;protein localization to mitochondrion#GO:0070585;localization#GO:0051179;cellular localization#GO:0051641;localization within membrane#GO:0051668;protein insertion into mitochondrial outer membrane#GO:0045040;protein insertion into membrane#GO:0051205;cellular component assembly#GO:0022607;membrane organization#GO:0061024;mitochondrion organization#GO:0007005;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;macromolecule localization#GO:0033036;establishment of protein localization to membrane#GO:0090150;mitochondrial membrane organization#GO:0007006;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;protein-containing complex organization#GO:0043933 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;outer membrane#GO:0019867;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;membrane protein complex#GO:0098796;organelle envelope#GO:0031967;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;mitochondrial outer membrane#GO:0005741;mitochondrial outer membrane translocase complex#GO:0005742;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;organelle outer membrane#GO:0031968;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;membrane#GO:0016020 transporter#PC00227 HUMAN|HGNC=16793|UniProtKB=Q8TD07 Q8TD07 RAET1E PTHR16675:SF64 MHC CLASS I-RELATED RETINOIC ACID EARLY TRANSCRIPT 1E receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;binding#GO:0005488;signaling receptor binding#GO:0005102;protein binding#GO:0005515;molecular function activator activity#GO:0140677 regulation of cell killing#GO:0031341;regulation of lymphocyte mediated immunity#GO:0002706;immune system process#GO:0002376;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449;regulation of biological process#GO:0050789;natural killer cell mediated immunity#GO:0002228;leukocyte mediated cytotoxicity#GO:0001909;biological process involved in interspecies interaction between organisms#GO:0044419;positive regulation of adaptive immune response#GO:0002821;response to stimulus#GO:0050896;immune effector process#GO:0002252;natural killer cell mediated cytotoxicity#GO:0042267;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;defense response to symbiont#GO:0140546;positive regulation of immune system process#GO:0002684;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;defense response to other organism#GO:0098542;regulation of immune response#GO:0050776;regulation of leukocyte mediated cytotoxicity#GO:0001910;antigen processing and presentation#GO:0019882;regulation of immune effector process#GO:0002697;positive regulation of lymphocyte mediated immunity#GO:0002708;regulation of leukocyte mediated immunity#GO:0002703;response to external biotic stimulus#GO:0043207;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;cell killing#GO:0001906;positive regulation of leukocyte mediated immunity#GO:0002705;defense response#GO:0006952;response to external stimulus#GO:0009605;innate immune response#GO:0045087;positive regulation of cellular process#GO:0048522;immune response#GO:0006955;positive regulation of immune effector process#GO:0002699;response to other organism#GO:0051707;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584 membrane#GO:0016020;cell periphery#GO:0071944;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;extracellular region#GO:0005576;external side of plasma membrane#GO:0009897;side of membrane#GO:0098552 major histocompatibility complex protein#PC00149;defense/immunity protein#PC00090 HUMAN|HGNC=25582|UniProtKB=Q9NVC3 Q9NVC3 SLC38A7 PTHR22950:SF192 AMINO ACID TRANSPORTER SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 7 amino acid transmembrane transporter activity#GO:0015171;neutral L-amino acid transmembrane transporter activity#GO:0015175;transporter activity#GO:0005215;carboxylic acid transmembrane transporter activity#GO:0046943;transmembrane transporter activity#GO:0022857;L-amino acid transmembrane transporter activity#GO:0015179 amino acid transmembrane transport#GO:0003333;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;amino acid transport#GO:0006865;transport#GO:0006810;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;membrane#GO:0016020 secondary carrier transporter#PC00258;amino acid transporter#PC00046 HUMAN|HGNC=15095|UniProtKB=Q8NGU2 Q8NGU2 OR9A4 PTHR24242:SF216 G-PROTEIN COUPLED RECEPTOR OLFACTORY RECEPTOR 9A4 G-protein coupled receptor#PC00021 HUMAN|HGNC=16815|UniProtKB=Q8TCT1 Q8TCT1 PHOSPHO1 PTHR20889:SF2 PHOSPHATASE, ORPHAN 1, 2 PHOSPHOETHANOLAMINE_PHOSPHOCHOLINE PHOSPHATASE hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788 skeletal system morphogenesis#GO:0048705;bone development#GO:0060348;tissue development#GO:0009888;multicellular organismal process#GO:0032501;developmental maturation#GO:0021700;bone mineralization#GO:0030282;developmental process#GO:0032502;animal organ development#GO:0048513;multicellular organism development#GO:0007275;anatomical structure maturation#GO:0071695;anatomical structure morphogenesis#GO:0009653;ossification#GO:0001503;animal organ morphogenesis#GO:0009887;animal gross anatomical part developmental process#GO:0160108;biomineral tissue development#GO:0031214;anatomical structure development#GO:0048856;skeletal system development#GO:0001501;system development#GO:0048731 extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;membrane-bounded organelle#GO:0043227;organelle#GO:0043226;cellular anatomical structure#GO:0110165 hydrolase#PC00121;phosphatase#PC00181 HUMAN|HGNC=9612|UniProtKB=Q14289 Q14289 PTK2B PTHR24418:SF94 TYROSINE-PROTEIN KINASE PROTEIN-TYROSINE KINASE 2-BETA catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein tyrosine kinase activity#GO:0004713;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;non-membrane spanning protein tyrosine kinase activity#GO:0004715 positive regulation of cell motility#GO:2000147;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cell communication#GO:0007154;regulation of cell motility#GO:2000145;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;ERBB signaling pathway#GO:0038127;positive regulation of cell migration#GO:0030335;regulation of cell adhesion#GO:0030155;epidermal growth factor receptor signaling pathway#GO:0007173;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;regulation of cell migration#GO:0030334;cell surface receptor signaling pathway#GO:0007166;positive regulation of locomotion#GO:0040017 anchoring junction#GO:0070161;cell junction#GO:0030054;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;focal adhesion#GO:0005925;cell-substrate junction#GO:0030055;cellular anatomical structure#GO:0110165 non-receptor tyrosine protein kinase#PC00168 Integrin signalling pathway#P00034>FAK#P00932;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PYK2#P00852;Gonadotropin-releasing hormone receptor pathway#P06664>Pyk2#P06730;CCKR signaling map#P06959>FAK2#P07218 HUMAN|HGNC=2859|UniProtKB=Q15392 Q15392 DHCR24 PTHR10801:SF21 24-DEHYDROCHOLESTEROL REDUCTASE DELTA(24)-STEROL REDUCTASE catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;oxidoreductase activity#GO:0016491 primary metabolic process#GO:0044238;small molecule metabolic process#GO:0044281;secondary alcohol metabolic process#GO:1902652;cellular process#GO:0009987;alcohol biosynthetic process#GO:0046165;lipid biosynthetic process#GO:0008610;cholesterol biosynthetic process#GO:0006695;biosynthetic process#GO:0009058;steroid metabolic process#GO:0008202;sterol biosynthetic process#GO:0016126;alcohol metabolic process#GO:0006066;metabolic process#GO:0008152;cholesterol metabolic process#GO:0008203;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;sterol metabolic process#GO:0016125;steroid biosynthetic process#GO:0006694;secondary alcohol biosynthetic process#GO:1902653 cellular anatomical structure#GO:0110165;membrane#GO:0016020 reductase#PC00198;oxidoreductase#PC00176 HUMAN|HGNC=26633|UniProtKB=Q7Z7L1 Q7Z7L1 SLFN11 PTHR12155:SF45 SCHLAFEN SCHLAFEN FAMILY MEMBER 11 RNA binding#GO:0003723;tRNA binding#GO:0000049;nucleic acid binding#GO:0003676;binding#GO:0005488 response to external stimulus#GO:0009605;defense response#GO:0006952;response to virus#GO:0009615;defense response to virus#GO:0051607;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to other organism#GO:0051707;response to stimulus#GO:0050896 endoribonuclease#PC00094 HUMAN|HGNC=29394|UniProtKB=Q5GH76 Q5GH76 XKR4 PTHR16024:SF16 XK-RELATED PROTEIN XK-RELATED PROTEIN 4 endomembrane system organization#GO:0010256;cellular process#GO:0009987;import into cell#GO:0098657;cellular component organization or biogenesis#GO:0071840;phagocytosis, engulfment#GO:0006911;apoptotic cell clearance#GO:0043277;membrane invagination#GO:0010324;endocytosis#GO:0006897;cellular component organization#GO:0016043;apoptotic process#GO:0006915;execution phase of apoptosis#GO:0097194;plasma membrane organization#GO:0007009;regulation of biological quality#GO:0065008;lipid localization#GO:0010876;lipid transport#GO:0006869;biological regulation#GO:0065007;phospholipid transport#GO:0015914;membrane organization#GO:0061024;phospholipid translocation#GO:0045332;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;regulation of membrane lipid distribution#GO:0097035;phagocytosis#GO:0006909;transport#GO:0006810;developmental process#GO:0032502;organophosphate ester transport#GO:0015748;plasma membrane phospholipid scrambling#GO:0017121;lipid translocation#GO:0034204;programmed cell death#GO:0012501;cell death#GO:0008219;anatomical structure development#GO:0048856;localization#GO:0051179 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 secondary carrier transporter#PC00258 HUMAN|HGNC=16672|UniProtKB=P50579 P50579 METAP2 PTHR45777:SF2 METHIONINE AMINOPEPTIDASE 2 METHIONINE AMINOPEPTIDASE 2 hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;metalloexopeptidase activity#GO:0008235;aminopeptidase activity#GO:0004177;catalytic activity#GO:0003824 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protease#PC00190;protein modifying enzyme#PC00260 HUMAN|HGNC=8153|UniProtKB=P41143 P41143 OPRD1 PTHR24229:SF2 NEUROPEPTIDES RECEPTOR DELTA-TYPE OPIOID RECEPTOR transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;neuropeptide binding#GO:0042923;peptide binding#GO:0042277;binding#GO:0005488;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;neuropeptide signaling pathway#GO:0007218;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052 membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005;cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;cell projection#GO:0042995 G-protein coupled receptor#PC00021 Opioid proopiomelanocortin pathway#P05917>Mu or Delta receptor#P06004;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;Enkephalin release#P05913>GPCR (i)#P05973;Opioid proenkephalin pathway#P05915>Mu or Delta receptor#P05985;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GoPCR#P00725 HUMAN|HGNC=26836|UniProtKB=Q08AI6 Q08AI6 SLC38A11 PTHR22950:SF708 AMINO ACID TRANSPORTER SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 11-RELATED amino acid transmembrane transporter activity#GO:0015171;transporter activity#GO:0005215;carboxylic acid transmembrane transporter activity#GO:0046943;transmembrane transporter activity#GO:0022857;L-amino acid transmembrane transporter activity#GO:0015179 transmembrane transport#GO:0055085;establishment of localization#GO:0051234;amino acid transmembrane transport#GO:0003333;localization#GO:0051179;amino acid transport#GO:0006865;cellular process#GO:0009987;transport#GO:0006810 membrane#GO:0016020;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258;amino acid transporter#PC00046 HUMAN|HGNC=11529|UniProtKB=P16422 P16422 EPCAM PTHR14168:SF2 TUMOR-ASSOCIATED CALCIUM SIGNAL TRANSDUCER EPITHELIAL CELL ADHESION MOLECULE protein binding#GO:0005515;cell-cell adhesion mediator activity#GO:0098632;binding#GO:0005488;cell adhesion molecule binding#GO:0050839;cell adhesion mediator activity#GO:0098631 cell-cell adhesion#GO:0098609;cellular process#GO:0009987;cell adhesion#GO:0007155 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;bicellular tight junction#GO:0005923;cell periphery#GO:0071944;basal plasma membrane#GO:0009925;cell-cell junction#GO:0005911;membrane#GO:0016020;basolateral plasma membrane#GO:0016323;basal part of cell#GO:0045178;anchoring junction#GO:0070161;tight junction#GO:0070160;cell junction#GO:0030054;extracellular region#GO:0005576;apical junction complex#GO:0043296 HUMAN|HGNC=10254|UniProtKB=Q03395 Q03395 ROM1 PTHR19282:SF234 TETRASPANIN ROD OUTER SEGMENT MEMBRANE PROTEIN 1 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HUMAN|HGNC=12485|UniProtKB=P63279 P63279 UBE2I PTHR24067:SF280 UBIQUITIN-CONJUGATING ENZYME E2 SUMO-CONJUGATING ENZYME UBC9 transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;SUMO transferase activity#GO:0019789;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-like protein conjugating enzyme activity#GO:0061650 protein modification by small protein conjugation#GO:0032446;cellular process#GO:0009987;protein modification process#GO:0036211;primary metabolic process#GO:0044238;post-translational protein modification#GO:0043687;metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647;protein sumoylation#GO:0016925;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=11290|UniProtKB=Q12772 Q12772 SREBF2 PTHR46062:SF3 STEROL REGULATORY ELEMENT-BINDING PROTEIN STEROL REGULATORY ELEMENT-BINDING PROTEIN 2 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of gene expression#GO:0010468;regulation of localization#GO:0032879;regulation of biosynthetic process#GO:0009889;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;regulation of biological process#GO:0050789;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=13666|UniProtKB=Q9NRG9 Q9NRG9 AAAS PTHR14494:SF0 ALADIN/ADRACALIN/AAAS ALADIN molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 organelle assembly#GO:0070925;nuclear division#GO:0000280;microtubule bundle formation#GO:0001578;microtubule cytoskeleton organization#GO:0000226;organelle fission#GO:0048285;cell cycle#GO:0007049;nuclear chromosome segregation#GO:0098813;cellular component organization#GO:0016043;microtubule cytoskeleton organization involved in mitosis#GO:1902850;sister chromatid segregation#GO:0000819;membraneless organelle assembly#GO:0140694;cell cycle process#GO:0022402;mitotic nuclear division#GO:0140014;mitotic cell cycle#GO:0000278;mitotic spindle organization#GO:0007052;chromosome segregation#GO:0007059;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;mitotic cell cycle process#GO:1903047;chromosome organization#GO:0051276;microtubule-based process#GO:0007017;cellular component biogenesis#GO:0044085;mitotic sister chromatid segregation#GO:0000070;organelle organization#GO:0006996;spindle assembly#GO:0051225;mitotic spindle assembly#GO:0090307;cellular process#GO:0009987;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010 intracellular anatomical structure#GO:0005622;nuclear pore#GO:0005643;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;organelle envelope#GO:0031967 HUMAN|HGNC=7566|UniProtKB=P23409 P23409 MYF6 PTHR11534:SF4 MYOGENIC FACTOR MYOGENIC FACTOR 6 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of multicellular organismal process#GO:0051239;positive regulation of cell development#GO:0010720;striated muscle tissue development#GO:0014706;positive regulation of cell differentiation#GO:0045597;muscle organ development#GO:0007517;animal organ development#GO:0048513;regulation of biological process#GO:0050789;positive regulation of multicellular organismal process#GO:0051240;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;skeletal muscle organ development#GO:0060538;animal gross anatomical part developmental process#GO:0160108;positive regulation of cellular process#GO:0048522;skeletal muscle tissue development#GO:0007519;regulation of cell development#GO:0060284;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;tissue development#GO:0009888;positive regulation of developmental process#GO:0051094;developmental process#GO:0032502;regulation of cell differentiation#GO:0045595;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of developmental process#GO:0050793;regulation of macromolecule metabolic process#GO:0060255;muscle structure development#GO:0061061;regulation of cellular process#GO:0050794;muscle tissue development#GO:0060537;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856 nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=30881|UniProtKB=Q9NP73 Q9NP73 ALG13 PTHR12867:SF6 GLYCOSYL TRANSFERASE-RELATED UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG13 metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487;glycoprotein biosynthetic process#GO:0009101;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;biosynthetic process#GO:0009058 transferase#PC00220 HUMAN|HGNC=26820|UniProtKB=Q6NT55 Q6NT55 CYP4F22 PTHR24291:SF53 CYTOCHROME P450 FAMILY 4 ULTRA-LONG-CHAIN FATTY ACID OMEGA-HYDROXYLASE metabolite interconversion enzyme#PC00262;oxygenase#PC00177;oxidoreductase#PC00176 HUMAN|HGNC=30494|UniProtKB=Q68DE3 Q68DE3 USF3 PTHR46970:SF1 BASIC HELIX-LOOP-HELIX DOMAIN-CONTAINING PROTEIN USF3 BASIC HELIX-LOOP-HELIX DOMAIN-CONTAINING PROTEIN USF3 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=14221|UniProtKB=Q96P15 Q96P15 SERPINB11 PTHR11461:SF199 SERINE PROTEASE INHIBITOR, SERPIN SERPIN B11 enzyme inhibitor activity#GO:0004857;molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866;peptidase regulator activity#GO:0061134;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414;serine-type endopeptidase inhibitor activity#GO:0004867;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease inhibitor#PC00191 HUMAN|HGNC=11109|UniProtKB=Q969G3 Q969G3 SMARCE1 PTHR46232:SF2 SMARCE1 REGULATOR OF CHROMATIN SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY E MEMBER 1 transcription factor binding#GO:0008134;nuclear receptor binding#GO:0016922;binding#GO:0005488;protein binding#GO:0005515;RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629;DNA-binding transcription factor binding#GO:0140297 regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605 catalytic complex#GO:1902494;intracellular organelle#GO:0043229;SWI/SNF complex#GO:0016514;ATPase complex#GO:1904949;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;chromosome#GO:0005694;SWI/SNF superfamily-type complex#GO:0070603;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;nucleus#GO:0005634;chromatin#GO:0000785;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232 chromatin/chromatin-binding, or -regulatory protein#PC00077 Wnt signaling pathway#P00057>SWI/SNF#P01435 HUMAN|HGNC=16811|UniProtKB=Q9UJT1 Q9UJT1 TUBD1 PTHR11588:SF4 TUBULIN TUBULIN DELTA CHAIN anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167;structural molecule activity#GO:0005198;nucleotide binding#GO:0000166;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;structural constituent of cytoskeleton#GO:0005200;binding#GO:0005488;nucleoside phosphate binding#GO:1901265;guanyl nucleotide binding#GO:0019001;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553 organelle organization#GO:0006996;cell cycle#GO:0007049;cellular component organization#GO:0016043;cellular process#GO:0009987;mitotic cell cycle#GO:0000278;cytoskeleton organization#GO:0007010;cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226;microtubule-based process#GO:0007017 membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;centrosome#GO:0005813;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;microtubule cytoskeleton#GO:0015630;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;microtubule#GO:0005874;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226 cytoskeletal protein#PC00085;tubulin#PC00228 HUMAN|HGNC=17016|UniProtKB=O95251 O95251 KAT7 PTHR10615:SF222 HISTONE ACETYLTRANSFERASE HISTONE ACETYLTRANSFERASE KAT7 histone acetyltransferase activity#GO:0004402;N-acetyltransferase activity#GO:0008080;chromatin binding#GO:0003682;acyltransferase activity#GO:0016746;protein-lysine-acetyltransferase activity#GO:0061733;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity, acting on a protein#GO:0140096;transcription coregulator activity#GO:0003712;catalytic activity#GO:0003824;histone modifying activity#GO:0140993;protein N-acyltransferase activity#GO:0140186;transcription regulator activity#GO:0140110;binding#GO:0005488;acetyltransferase activity#GO:0016407;protein N-acetyltransferase activity#GO:0034212;transferase activity#GO:0016740 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 chromatin#GO:0000785;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;histone acetyltransferase complex#GO:0000123;intracellular protein-containing complex#GO:0140535;chromosome#GO:0005694;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;protein acetyltransferase complex#GO:0031248;membrane-bounded organelle#GO:0043227;acetyltransferase complex#GO:1902493;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077;histone modifying enzyme#PC00261 Alzheimer disease-presenilin pathway#P00004>Tip60#P00137 HUMAN|HGNC=14864|UniProtKB=P25940 P25940 COL5A3 PTHR24023:SF1023 COLLAGEN ALPHA COLLAGEN ALPHA-3(V) CHAIN structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;external encapsulating structure organization#GO:0045229;cellular component organization#GO:0016043;extracellular structure organization#GO:0043062;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 Integrin signalling pathway#P00034>Collagen#P00922 HUMAN|HGNC=9469|UniProtKB=O14668 O14668 PRRG1 PTHR24278:SF37 COAGULATION FACTOR TRANSMEMBRANE GAMMA-CARBOXYGLUTAMIC ACID PROTEIN 1 catalytic activity#GO:0003824;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 serine protease#PC00203 HUMAN|HGNC=3506|UniProtKB=P49640 P49640 EVX1 PTHR46294:SF2 SEGMENTATION PROTEIN EVEN-SKIPPED HOMEOBOX EVEN-SKIPPED HOMOLOG PROTEIN 1 binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=15251|UniProtKB=Q8NH90 Q8NH90 OR5AK2 PTHR48018:SF179 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5AK2 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 biological regulation#GO:0065007;multicellular organismal process#GO:0032501;cellular process#GO:0009987;signal transduction#GO:0007165;system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606;signaling#GO:0023052;sensory perception of smell#GO:0007608;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cell communication#GO:0007154;nervous system process#GO:0050877;sensory perception#GO:0007600;G protein-coupled receptor signaling pathway#GO:0007186 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=1366|UniProtKB=Q76LX8 Q76LX8 ADAMTS13 PTHR13723:SF20 ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 13 hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 cellular process#GO:0009987;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;proteolysis#GO:0006508;metabolic process#GO:0008152;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;extracellular matrix organization#GO:0030198 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 HUMAN|HGNC=7839|UniProtKB=P78426 P78426 NKX6-1 PTHR24340:SF31 HOMEOBOX PROTEIN NKX HOMEOBOX PROTEIN NKX-6.1 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;developmental process#GO:0032502 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=7756|UniProtKB=P48681 P48681 NES PTHR47051:SF1 NESTIN NESTIN cytokine receptor binding#GO:0005126;binding#GO:0005488;signaling receptor binding#GO:0005102;G protein-coupled receptor binding#GO:0001664;protein binding#GO:0005515;chemokine receptor binding#GO:0042379 positive regulation of organelle organization#GO:0010638;regulation of protein depolymerization#GO:1901879;positive regulation of cellular component organization#GO:0051130;regulation of cellular process#GO:0050794;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;biological regulation#GO:0065007;regulation of protein-containing complex disassembly#GO:0043244;regulation of organelle organization#GO:0033043;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;intermediate filament#GO:0005882;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;organelle#GO:0043226;supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232 HUMAN|HGNC=19904|UniProtKB=Q9C0G0 Q9C0G0 ZNF407 PTHR24403:SF60 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 407 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HUMAN|HGNC=33748|UniProtKB=Q6BDI9 Q6BDI9 REP15 PTHR36682:SF1 RAB15 EFFECTOR PROTEIN RAB15 EFFECTOR PROTEIN intracellular protein localization#GO:0008104;monoatomic ion transport#GO:0006811;protein transport#GO:0015031;monoatomic cation transport#GO:0006812;macromolecule metabolic process#GO:0043170;localization#GO:0051179;establishment of localization#GO:0051234;iron ion transport#GO:0006826;transport#GO:0006810;transition metal ion transport#GO:0000041;metabolic process#GO:0008152;metal ion transport#GO:0030001;establishment of protein localization#GO:0045184;cellular process#GO:0009987;macromolecule localization#GO:0033036 membrane#GO:0016020;vesicle membrane#GO:0012506;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;cytoplasm#GO:0005737;recycling endosome#GO:0055037;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;endosome membrane#GO:0010008;endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=29804|UniProtKB=Q8N3F8 Q8N3F8 MICALL1 PTHR23167:SF89 CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED MICAL-LIKE PROTEIN 1 cytoskeleton organization#GO:0007010;cellular component organization or biogenesis#GO:0071840;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987;actin filament-based process#GO:0030029;organelle organization#GO:0006996;cellular component organization#GO:0016043 scaffold/adaptor protein#PC00226 Integrin signalling pathway#P00034>alpha actinin#P00928 HUMAN|HGNC=16692|UniProtKB=Q9NPF0 Q9NPF0 CD320 PTHR24270:SF62 LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED CD320 ANTIGEN cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 apolipoprotein#PC00052;transfer/carrier protein#PC00219 HUMAN|HGNC=3578|UniProtKB=Q9UNN5 Q9UNN5 FAF1 PTHR23322:SF96 FAS-ASSOCIATED PROTEIN FAS-ASSOCIATED FACTOR 1 DNA-binding transcription factor binding#GO:0140297;protein binding#GO:0005515;RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629;ubiquitin binding#GO:0043130;transcription factor binding#GO:0008134;binding#GO:0005488 primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;catabolic process#GO:0009056;response to stimulus#GO:0050896;response to endoplasmic reticulum stress#GO:0034976;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;ERAD pathway#GO:0036503;response to stress#GO:0006950;cellular process#GO:0009987;response to chemical#GO:0042221;proteasomal protein catabolic process#GO:0010498;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 FAS signaling pathway#P00020>FAF1#P00609 HUMAN|HGNC=19864|UniProtKB=Q9UKI9 Q9UKI9 POU2F3 PTHR11636:SF81 POU DOMAIN POU DOMAIN, CLASS 2, TRANSCRIPTION FACTOR 3 transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 nuclear protein-containing complex#GO:0140513;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=42951|UniProtKB=F2Z333 F2Z333 FNDC10 PTHR39233:SF1 FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN 10 FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN 10 HUMAN|HGNC=25009|UniProtKB=Q9NPD8 Q9NPD8 UBE2T PTHR24068:SF159 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2 T ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein conjugating enzyme activity#GO:0061650;transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin conjugating enzyme activity#GO:0061631 macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;DNA damage response#GO:0006974;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;response to stress#GO:0006950;cellular process#GO:0009987;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;protein modification by small protein conjugation or removal#GO:0070647;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;cellular response to stimulus#GO:0051716 ubiquitin-protein ligase#PC00234 Ubiquitin proteasome pathway#P00060>E2#P01491 HUMAN|HGNC=24855|UniProtKB=Q7Z6B0 Q7Z6B0 CCDC91 PTHR35072:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 91 COILED-COIL DOMAIN-CONTAINING PROTEIN 91 vacuolar transport#GO:0007034;transport#GO:0006810;Golgi vesicle transport#GO:0048193;lysosomal transport#GO:0007041;intracellular transport#GO:0046907;post-Golgi vesicle-mediated transport#GO:0006892;localization#GO:0051179;Golgi to vacuole transport#GO:0006896;establishment of localization#GO:0051234;cellular localization#GO:0051641;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;cytosolic transport#GO:0016482;vesicle-mediated transport#GO:0016192 Golgi apparatus subcompartment#GO:0098791;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=9162|UniProtKB=Q9H307 Q9H307 PNN PTHR12707:SF0 PINN PININ nucleus#GO:0005634;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;catalytic step 2 spliceosome#GO:0071013 HUMAN|HGNC=4128|UniProtKB=Q8NCL4 Q8NCL4 GALNT6 PTHR11675:SF58 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 6 polypeptide N-acetylgalactosaminyltransferase activity#GO:0004653;catalytic activity, acting on a protein#GO:0140096;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;acetylgalactosaminyltransferase activity#GO:0008376;hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;catalytic activity#GO:0003824 metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;protein O-linked glycosylation#GO:0006493;macromolecule biosynthetic process#GO:0009059;biosynthetic process#GO:0009058 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 glycosyltransferase#PC00111;transferase#PC00220 HUMAN|HGNC=26664|UniProtKB=Q8N841 Q8N841 TTLL6 PTHR12241:SF96 TUBULIN POLYGLUTAMYLASE TUBULIN POLYGLUTAMYLASE TTLL6 binding#GO:0005488;ligase activity, forming carbon-nitrogen bonds#GO:0016879;protein binding#GO:0005515;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;ligase activity#GO:0016874;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 microtubule bundle formation#GO:0001578;microtubule-based process#GO:0007017;microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010 intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microtubule cytoskeleton#GO:0015630;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;cilium#GO:0005929;intracellular organelle#GO:0043229;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;ciliary basal body#GO:0036064 microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=5156|UniProtKB=P00739 P00739 HPR PTHR24255:SF27 COMPLEMENT COMPONENT 1, S SUBCOMPONENT-RELATED HAPTOGLOBIN-RELATED PROTEIN peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;serine-type peptidase activity#GO:0008236 protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;zymogen activation#GO:0031638;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604;metabolic process#GO:0008152;proteolysis#GO:0006508;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 serine protease#PC00203 HUMAN|HGNC=9882|UniProtKB=Q9NS23 Q9NS23 RASSF1 PTHR22738:SF12 RASSF RAS ASSOCIATION DOMAIN-CONTAINING PROTEIN 1 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;signaling#GO:0023052;small GTPase-mediated signal transduction#GO:0007264;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;Ras protein signal transduction#GO:0007265;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 microtubule cytoskeleton#GO:0015630;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HUMAN|HGNC=29136|UniProtKB=O94953 O94953 KDM4B PTHR10694:SF30 LYSINE-SPECIFIC DEMETHYLASE LYSINE-SPECIFIC DEMETHYLASE 4B histone modifying activity#GO:0140993;dioxygenase activity#GO:0051213;protein demethylase activity#GO:0140457;oxidoreductase activity#GO:0016491;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;demethylase activity#GO:0032451;catalytic activity, acting on a protein#GO:0140096;histone demethylase activity#GO:0032452;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824 chromatin remodeling#GO:0006338;chromatin organization#GO:0006325;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;cellular process#GO:0009987;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840 chromosome#GO:0005694;nucleus#GO:0005634;chromatin#GO:0000785;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 histone modifying enzyme#PC00261 HUMAN|HGNC=12585|UniProtKB=P31930 P31930 UQCRC1 PTHR11851:SF116 METALLOPROTEASE CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 macromolecule localization#GO:0033036;protein localization to mitochondrion#GO:0070585;localization#GO:0051179;protein localization to organelle#GO:0033365;intracellular protein localization#GO:0008104 endopeptidase complex#GO:1905369;peptidase complex#GO:1905368;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;membrane-enclosed lumen#GO:0031974;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;organelle lumen#GO:0043233 protease#PC00190;metalloprotease#PC00153 HUMAN|HGNC=2623|UniProtKB=P11712 P11712 CYP2C9 PTHR24300:SF400 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 2C9 binding#GO:0005488;tetrapyrrole binding#GO:0046906;catalytic activity#GO:0003824;monooxygenase activity#GO:0004497;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;heme binding#GO:0020037;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen#GO:0016712 olefinic compound metabolic process#GO:0120254;oxoacid metabolic process#GO:0043436;cellular response to chemical stimulus#GO:0070887;response to xenobiotic stimulus#GO:0009410;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;xenobiotic metabolic process#GO:0006805;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;arachidonate metabolic process#GO:0019369;cellular response to stimulus#GO:0051716;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;unsaturated fatty acid metabolic process#GO:0033559;icosanoid metabolic process#GO:0006690;response to chemical#GO:0042221;cellular response to xenobiotic stimulus#GO:0071466;long-chain fatty acid metabolic process#GO:0001676;cellular process#GO:0009987 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229 oxidoreductase#PC00176;oxygenase#PC00177 HUMAN|HGNC=7380|UniProtKB=P26927 P26927 MST1 PTHR24261:SF12 PLASMINOGEN-RELATED HEPATOCYTE GROWTH FACTOR-LIKE PROTEIN-RELATED protein binding#GO:0005515;hydrolase activity#GO:0016787;kinase binding#GO:0019900;protein tyrosine kinase binding#GO:1990782;signaling receptor binding#GO:0005102;binding#GO:0005488;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity#GO:0003824;receptor tyrosine kinase binding#GO:0030971 regulation of biological process#GO:0050789;regulation of cell communication#GO:0010646;regulation of receptor signaling pathway via STAT#GO:1904892;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of signaling#GO:0023051;regulation of receptor signaling pathway via JAK-STAT#GO:0046425;regulation of response to stimulus#GO:0048583 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protein modifying enzyme#PC00260;serine protease#PC00203 HUMAN|HGNC=31303|UniProtKB=A6NCV1 A6NCV1 OR6C74 PTHR26454:SF72 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 6C74 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=8270|UniProtKB=Q96R27 Q96R27 OR2M4 PTHR26453:SF91 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2M4 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 response to chemical#GO:0042221;response to stimulus#GO:0050896;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;detection of chemical stimulus#GO:0009593;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;system process#GO:0003008;sensory perception#GO:0007600;nervous system process#GO:0050877;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=12949|UniProtKB=Q14119 Q14119 VEZF1 PTHR24379:SF75 KRAB AND ZINC FINGER DOMAIN-CONTAINING VASCULAR ENDOTHELIAL ZINC FINGER 1 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HUMAN|HGNC=6235|UniProtKB=Q14003 Q14003 KCNC3 PTHR11537:SF184 VOLTAGE-GATED POTASSIUM CHANNEL VOLTAGE-GATED POTASSIUM CHANNEL KCNC3 gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;transporter activity#GO:0005215;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;potassium channel activity#GO:0005267;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261 action potential#GO:0001508;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;potassium ion transmembrane transport#GO:0071805;biological regulation#GO:0065007;monoatomic cation transmembrane transport#GO:0098655;transport#GO:0006810;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391 transmembrane transporter complex#GO:1902495;dendrite#GO:0030425;dendritic tree#GO:0097447;axon#GO:0030424;neuronal cell body#GO:0043025;neuron projection terminus#GO:0044306;distal axon#GO:0150034;plasma membrane bounded cell projection#GO:0120025;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;axon terminus#GO:0043679;neuron projection membrane#GO:0032589;voltage-gated potassium channel complex#GO:0008076;plasma membrane region#GO:0098590;monoatomic ion channel complex#GO:0034702;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;presynaptic membrane#GO:0042734;membrane#GO:0016020;cell periphery#GO:0071944;cell projection membrane#GO:0031253;postsynaptic membrane#GO:0045211;leading edge membrane#GO:0031256;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;postsynapse#GO:0098794;cell body#GO:0044297;cell junction#GO:0030054;transporter complex#GO:1990351;cation channel complex#GO:0034703;synaptic membrane#GO:0097060;protein-containing complex#GO:0032991;cell leading edge#GO:0031252;presynapse#GO:0098793;neuron projection#GO:0043005 voltage-gated ion channel#PC00241;ion channel#PC00133 HUMAN|HGNC=18829|UniProtKB=Q6JEL2 Q6JEL2 KLHL10 PTHR24412:SF172 KELCH PROTEIN KELCH-LIKE PROTEIN 10 ubiquitin-like ligase-substrate adaptor activity#GO:1990756;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;enzyme-substrate adaptor activity#GO:0140767 catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cullin-RING ubiquitin ligase complex#GO:0031461;cytoplasm#GO:0005737;transferase complex#GO:1990234;catalytic complex#GO:1902494;Cul3-RING ubiquitin ligase complex#GO:0031463;ubiquitin ligase complex#GO:0000151;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HUMAN|HGNC=23747|UniProtKB=Q9HA82 Q9HA82 CERS4 PTHR12560:SF6 LONGEVITY ASSURANCE FACTOR 1 LAG1 CERAMIDE SYNTHASE 4 acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 ceramide metabolic process#GO:0006672;lipid metabolic process#GO:0006629;ceramide biosynthetic process#GO:0046513;sphingolipid biosynthetic process#GO:0030148;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;cellular process#GO:0009987;primary metabolic process#GO:0044238 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 metabolite interconversion enzyme#PC00262;transferase#PC00220 HUMAN|HGNC=20715|UniProtKB=Q9NPA3 Q9NPA3 MID1IP1 PTHR14315:SF16 SPOT14 FAMILY MEMBER MID1-INTERACTING PROTEIN 1 molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;enzyme activator activity#GO:0008047 regulation of cellular process#GO:0050794;regulation of lipid biosynthetic process#GO:0046890;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of lipid metabolic process#GO:0019216 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;cytosol#GO:0005829;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=9841|UniProtKB=Q15311 Q15311 RALBP1 PTHR12783:SF5 RALA BINDING PROTEIN 1 RALBP1 RALA-BINDING PROTEIN 1 nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047 transport#GO:0006810;establishment of localization#GO:0051234;import into cell#GO:0098657;receptor-mediated endocytosis#GO:0006898;signal transduction#GO:0007165;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;intracellular signaling cassette#GO:0141124;cell communication#GO:0007154;localization#GO:0051179;intracellular signal transduction#GO:0035556;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;endocytosis#GO:0006897;regulation of cellular process#GO:0050794;signaling#GO:0023052 membrane#GO:0016020;cellular anatomical structure#GO:0110165 GTPase-activating protein#PC00257;G-protein modulator#PC00022 HUMAN|HGNC=26980|UniProtKB=A6NE01 A6NE01 FAM186A PTHR33590:SF2 GLUTENIN, HIGH MOLECULAR WEIGHT SUBUNIT PW212-RELATED PROTEIN PROTEIN FAM186A HUMAN|HGNC=25012|UniProtKB=Q3ZCW2 Q3ZCW2 LGALSL PTHR11346:SF98 GALECTIN GALECTIN-RELATED PROTEIN binding#GO:0005488;carbohydrate binding#GO:0030246 extracellular matrix protein#PC00102 HUMAN|HGNC=7704|UniProtKB=Q9Y6M9 Q9Y6M9 NDUFB9 PTHR12868:SF1 NADH-UBIQUINONE OXIDOREDUCTASE B22 SUBUNIT NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 9 membrane#GO:0016020;oxidoreductase complex#GO:1990204;membrane protein complex#GO:0098796;respiratory chain complex#GO:0098803;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;respiratory chain complex I#GO:0045271;catalytic complex#GO:1902494;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=16881|UniProtKB=Q7RTV5 Q7RTV5 PRXL2C PTHR28630:SF34 FAMILY NOT NAMED PEROXIREDOXIN-LIKE 2C HUMAN|HGNC=15029|UniProtKB=Q8NGY2 Q8NGY2 OR6K2 PTHR26451:SF68 G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN OLFACTORY RECEPTOR 6K2 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;binding#GO:0005488;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 system process#GO:0003008;sensory perception#GO:0007600;nervous system process#GO:0050877;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;response to stimulus#GO:0050896;response to chemical#GO:0042221;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;detection of chemical stimulus#GO:0009593;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906 membrane#GO:0016020;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021 HUMAN|HGNC=14366|UniProtKB=Q9H239 Q9H239 MMP28 PTHR10201:SF298 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE-28 catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;metalloendopeptidase activity#GO:0004222;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 cellular process#GO:0009987;cellular component organization#GO:0016043;catabolic process#GO:0009056;extracellular structure organization#GO:0043062;metabolic process#GO:0008152;external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 Alzheimer disease-presenilin pathway#P00004>Matrix metalloprotease#P00130 HUMAN|HGNC=21050|UniProtKB=Q5VV42 Q5VV42 CDKAL1 PTHR11918:SF45 RADICAL SAM PROTEINS THREONYLCARBAMOYLADENOSINE TRNA METHYLTHIOTRANSFERASE transferase activity, transferring sulphur-containing groups#GO:0016782;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity#GO:0016740;catalytic activity#GO:0003824 translation#GO:0006412;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein biosynthetic process#GO:0160307 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 HUMAN|HGNC=12680|UniProtKB=P15692 P15692 VEGFA PTHR12025:SF5 VASCULAR ENDOTHELIAL GROWTH FACTOR VASCULAR ENDOTHELIAL GROWTH FACTOR A, LONG FORM signaling receptor binding#GO:0005102;binding#GO:0005488;cytokine receptor binding#GO:0005126;protein binding#GO:0005515;molecular function activator activity#GO:0140677;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;growth factor receptor binding#GO:0070851;growth factor activity#GO:0008083;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772 cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;circulatory system development#GO:0072359;signaling#GO:0023052;response to endogenous stimulus#GO:0009719;regulation of chemotaxis#GO:0050920;positive regulation of cell motility#GO:2000147;vascular endothelial growth factor receptor signaling pathway#GO:0048010;blood vessel morphogenesis#GO:0048514;response to abiotic stimulus#GO:0009628;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;angiogenesis#GO:0001525;cellular response to growth factor stimulus#GO:0071363;sprouting angiogenesis#GO:0002040;animal gross anatomical part developmental process#GO:0160108;regulation of response to external stimulus#GO:0032101;response to stress#GO:0006950;positive regulation of immune system process#GO:0002684;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;multicellular organism development#GO:0007275;positive regulation of response to external stimulus#GO:0032103;vasculature development#GO:0001944;anatomical structure formation involved in morphogenesis#GO:0048646;cell surface receptor signaling pathway#GO:0007166;regulation of leukocyte migration#GO:0002685;response to growth factor#GO:0070848;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;response to oxygen levels#GO:0070482;response to decreased oxygen levels#GO:0036293;blood vessel development#GO:0001568;tube morphogenesis#GO:0035239;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;regulation of cell motility#GO:2000145;positive regulation of chemotaxis#GO:0050921;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;system development#GO:0048731;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of response to stimulus#GO:0048584;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;tube development#GO:0035295;positive regulation of cellular process#GO:0048522;positive regulation of cell migration#GO:0030335;response to hypoxia#GO:0001666;positive regulation of locomotion#GO:0040017;regulation of cell migration#GO:0030334;developmental process#GO:0032502;regulation of response to stimulus#GO:0048583 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 growth factor#PC00112;intercellular signal molecule#PC00207 VEGF signaling pathway#P00056>VEGF#P01406;Angiogenesis#P00005>VEGF#P00241 HUMAN|HGNC=24447|UniProtKB=Q9NRP2 Q9NRP2 CMC2 PTHR22977:SF1 COX ASSEMBLY MITOCHONDRIAL PROTEIN COX ASSEMBLY MITOCHONDRIAL PROTEIN 2 HOMOLOG membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739 HUMAN|HGNC=10609|UniProtKB=P22362 P22362 CCL1 PTHR12015:SF5 SMALL INDUCIBLE CYTOKINE A C-C MOTIF CHEMOKINE 1 signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;G protein-coupled receptor binding#GO:0001664;chemokine activity#GO:0008009;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;molecular function activator activity#GO:0140677;protein binding#GO:0005515;chemokine receptor binding#GO:0042379;cytokine activity#GO:0005125;cytokine receptor binding#GO:0005126;signaling receptor binding#GO:0005102;binding#GO:0005488 positive regulation of locomotion#GO:0040017;myeloid leukocyte migration#GO:0097529;response to external stimulus#GO:0009605;leukocyte chemotaxis#GO:0030595;defense response#GO:0006952;regulation of cell migration#GO:0030334;leukocyte migration#GO:0050900;biological regulation#GO:0065007;response to other organism#GO:0051707;regulation of locomotion#GO:0040012;cell migration#GO:0016477;positive regulation of cellular process#GO:0048522;immune response#GO:0006955;positive regulation of cell migration#GO:0030335;cell chemotaxis#GO:0060326;cell communication#GO:0007154;regulation of cell motility#GO:2000145;chemokine-mediated signaling pathway#GO:0070098;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;chemotaxis#GO:0006935;inflammatory response#GO:0006954;cytokine-mediated signaling pathway#GO:0019221;response to external biotic stimulus#GO:0043207;locomotion#GO:0040011;cellular response to chemokine#GO:1990869;regulation of cellular process#GO:0050794;cell motility#GO:0048870;cellular response to stimulus#GO:0051716;cell surface receptor signaling pathway#GO:0007166;antimicrobial humoral response#GO:0019730;humoral immune response#GO:0006959;taxis#GO:0042330;response to cytokine#GO:0034097;response to chemical#GO:0042221;defense response to other organism#GO:0098542;granulocyte migration#GO:0097530;defense response to symbiont#GO:0140546;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;response to biotic stimulus#GO:0009607;response to chemokine#GO:1990868;response to stress#GO:0006950;response to peptide#GO:1901652;G protein-coupled receptor signaling pathway#GO:0007186;immune system process#GO:0002376;cellular response to chemical stimulus#GO:0070887;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;granulocyte chemotaxis#GO:0071621;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;positive regulation of cell motility#GO:2000147 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 cytokine#PC00083 HUMAN|HGNC=9937|UniProtKB=P35243 P35243 RCVRN PTHR23055:SF20 CALCIUM BINDING PROTEINS RECOVERIN metal ion binding#GO:0046872;cation binding#GO:0043169;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;calcium ion binding#GO:0005509 calmodulin-related#PC00061 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Recoverin#P00756 HUMAN|HGNC=6804|UniProtKB=P43360 P43360 MAGEA6 PTHR11736:SF60 MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN MELANOMA-ASSOCIATED ANTIGEN 3-RELATED protein binding#GO:0005515;histone deacetylase binding#GO:0042826;enzyme binding#GO:0019899;binding#GO:0005488 negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HUMAN|HGNC=17664|UniProtKB=Q9NQS3 Q9NQS3 NECTIN3 PTHR23277:SF12 NECTIN-RELATED NECTIN-3 binding#GO:0005488;cell adhesion molecule binding#GO:0050839;cell adhesion mediator activity#GO:0098631;protein binding#GO:0005515 homophilic cell-cell adhesion#GO:0007156;cell-cell adhesion#GO:0098609;cell adhesion#GO:0007155;cellular process#GO:0009987;heterophilic cell-cell adhesion#GO:0007157 cell periphery#GO:0071944;membrane#GO:0016020;cell-cell junction#GO:0005911;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;apical junction complex#GO:0043296;anchoring junction#GO:0070161;adherens junction#GO:0005912;cell junction#GO:0030054 cell adhesion molecule#PC00069 HUMAN|HGNC=26234|UniProtKB=Q96H55 Q96H55 MYO19 PTHR13140:SF289 MYOSIN UNCONVENTIONAL MYOSIN-XIX isomerase activity#GO:0016853;cytoskeletal motor activity#GO:0003774;ATP-dependent activity#GO:0140657;macromolecular conformation isomerase activity#GO:0120543;microfilament motor activity#GO:0000146;catalytic activity#GO:0003824;polypeptide conformation or assembly isomerase activity#GO:0120544 cellular component organization or biogenesis#GO:0071840;actin filament organization#GO:0007015;supramolecular fiber organization#GO:0097435;actin filament-based process#GO:0030029;actin cytoskeleton organization#GO:0030036;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987 intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;actin cytoskeleton#GO:0015629;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 actin binding motor protein#PC00040 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HUMAN|HGNC=14006|UniProtKB=Q9H1D0 Q9H1D0 TRPV6 PTHR10582:SF25 TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 6 monoatomic cation channel activity#GO:0005261;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;calcium channel activity#GO:0005262;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085 calcium ion transport#GO:0006816;inorganic cation import across plasma membrane#GO:0098659;establishment of localization#GO:0051234;import into cell#GO:0098657;calcium ion transmembrane import into cytosol#GO:0097553;transport#GO:0006810;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;metal ion transport#GO:0030001;inorganic ion import across plasma membrane#GO:0099587;import across plasma membrane#GO:0098739;calcium ion import#GO:0070509;calcium ion transmembrane transport#GO:0070588 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=26531|UniProtKB=Q96M89 Q96M89 CCDC138 PTHR34523:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 138 COILED-COIL DOMAIN-CONTAINING PROTEIN 138 HUMAN|HGNC=3964|UniProtKB=P01225 P01225 FSHB PTHR11515:SF17 GLYCOPROTEIN HORMONE BETA CHAIN FOLLITROPIN SUBUNIT BETA molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;hormone activity#GO:0005179;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545 sex differentiation#GO:0007548;cellular process#GO:0009987;signal transduction#GO:0007165;gonad development#GO:0008406;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;developmental process#GO:0032502;development of primary sexual characteristics#GO:0045137;animal organ development#GO:0048513;multicellular organism development#GO:0007275;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;developmental process involved in reproduction#GO:0003006;reproductive structure development#GO:0048608;reproductive process#GO:0022414;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;rhythmic process#GO:0048511;animal gross anatomical part developmental process#GO:0160108;G protein-coupled receptor signaling pathway#GO:0007186;multicellular organismal reproductive process#GO:0048609;reproductive system development#GO:0061458;system development#GO:0048731;female gonad development#GO:0008585;anatomical structure development#GO:0048856;cell communication#GO:0007154 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 peptide hormone#PC00179 Gonadotropin-releasing hormone receptor pathway#P06664>3' FSHbeta#G06900;Gonadotropin-releasing hormone receptor pathway#P06664>5' FSHbeta#G06904;Gonadotropin-releasing hormone receptor pathway#P06664>FSHbeta#P06809;Gonadotropin-releasing hormone receptor pathway#P06664>FSHbeta#G06678 HUMAN|HGNC=2186|UniProtKB=P12107 P12107 COL11A1 PTHR24023:SF42 COLLAGEN ALPHA COLLAGEN ALPHA-1(XI) CHAIN extracellular matrix structural constituent#GO:0005201;structural molecule activity#GO:0005198 cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;external encapsulating structure organization#GO:0045229;extracellular structure organization#GO:0043062;cellular component organization#GO:0016043;cellular process#GO:0009987 external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 Integrin signalling pathway#P00034>Collagen#P00922 HUMAN|HGNC=170|UniProtKB=P61158 P61158 ACTR3 PTHR11937:SF175 ACTIN ACTIN-RELATED PROTEIN 3 cytoskeletal protein binding#GO:0008092;structural molecule activity#GO:0005198;actin binding#GO:0003779;actin filament binding#GO:0051015;binding#GO:0005488;structural constituent of cytoskeleton#GO:0005200;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 cortical cytoskeleton organization#GO:0030865;actin filament-based process#GO:0030029;cellular component organization or biogenesis#GO:0071840;cortical actin cytoskeleton organization#GO:0030866;actin filament organization#GO:0007015;supramolecular fiber organization#GO:0097435;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;Arp2/3 complex-mediated actin nucleation#GO:0034314;actin cytoskeleton organization#GO:0030036;actin nucleation#GO:0045010;cytoskeleton organization#GO:0007010 intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;actin cytoskeleton#GO:0015629;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;Arp2/3 protein complex#GO:0005885;cytoskeleton#GO:0005856 actin and actin related protein#PC00039 HUMAN|HGNC=31791|UniProtKB=Q6ZT52 Q6ZT52 FAM43B PTHR11232:SF34 PHOSPHOTYROSINE INTERACTION DOMAIN-CONTAINING FAMILY MEMBER PROTEIN FAM43B signaling adaptor activity#GO:0035591;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 multicellular organismal process#GO:0032501;circulatory system development#GO:0072359;developmental process#GO:0032502;animal gross anatomical part developmental process#GO:0160108;vasculature development#GO:0001944;system development#GO:0048731;anatomical structure development#GO:0048856;multicellular organism development#GO:0007275 scaffold/adaptor protein#PC00226 HUMAN|HGNC=7316|UniProtKB=Q01362 Q01362 MS4A2 PTHR23320:SF66 MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED HIGH AFFINITY IMMUNOGLOBULIN EPSILON RECEPTOR SUBUNIT BETA cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007 side of membrane#GO:0098552;external side of plasma membrane#GO:0009897;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944 transporter#PC00227 HUMAN|HGNC=33754|UniProtKB=Q6PH81 Q6PH81 C16orf87 PTHR31101:SF3 UPF0547 PROTEIN C16ORF87 UPF0547 PROTEIN C16ORF87 HUMAN|HGNC=27256|UniProtKB=A6NEF3 A6NEF3 GOLGA6L4 PTHR23143:SF19 TRICHOHYALIN-RELATED GOLGIN A6 FAMILY LIKE 10-RELATED actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=30|UniProtKB=Q8WWZ4 Q8WWZ4 ABCA10 PTHR19229:SF269 ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 10 ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626;lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;lipid transport#GO:0006869;establishment of localization#GO:0051234;macromolecule localization#GO:0033036;lipid localization#GO:0010876;transport#GO:0006810 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 ATP-binding cassette (ABC) transporter#PC00003 HUMAN|HGNC=9390|UniProtKB=P31321 P31321 PRKAR1B PTHR11635:SF126 CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY SUBUNIT kinase binding#GO:0019900;binding#GO:0005488;nucleoside phosphate binding#GO:1901265;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;enzyme regulator activity#GO:0030234;protein binding#GO:0005515;molecular function inhibitor activity#GO:0140678;purine nucleotide binding#GO:0017076;protein kinase A binding#GO:0051018;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;kinase inhibitor activity#GO:0019210;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;protein kinase regulator activity#GO:0019887;kinase regulator activity#GO:0019207;small molecule binding#GO:0036094;anion binding#GO:0043168;ion binding#GO:0043167;enzyme inhibitor activity#GO:0004857;protein kinase inhibitor activity#GO:0004860;molecular function regulator activity#GO:0098772;nucleotide binding#GO:0000166 adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 cytosol#GO:0005829;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;transferase complex#GO:1990234;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695;serine/threonine protein kinase complex#GO:1902554;protein kinase complex#GO:1902911;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 protein-binding activity modulator#PC00095;kinase modulator#PC00140 Metabotropic glutamate receptor group I pathway#P00041>PKA#P01059;Hedgehog signaling pathway#P00025>PKA#P00682;Transcription regulation by bZIP transcription factor#P00055>PKA#P01384;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>PKA#P01075;Gonadotropin-releasing hormone receptor pathway#P06664>PKA#P06782;Metabotropic glutamate receptor group III pathway#P00039>PKA#P01035;Endothelin signaling pathway#P00019>PKA#P00570;GABA-B receptor II signaling#P05731>PKA#P05752;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>PKA-r#P00700;Metabotropic glutamate receptor group II pathway#P00040>PKA#P01050 HUMAN|HGNC=16973|UniProtKB=O96001 O96001 PPP1R17 PTHR15387:SF0 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 17 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 17 protein phosphatase inhibitor activity#GO:0004864;enzyme inhibitor activity#GO:0004857;phosphatase regulator activity#GO:0019208;phosphatase inhibitor activity#GO:0019212;molecular function regulator activity#GO:0098772;protein serine/threonine phosphatase inhibitor activity#GO:0004865;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;protein phosphatase regulator activity#GO:0019888 phosphatase modulator#PC00184 HUMAN|HGNC=21445|UniProtKB=Q9BSF8 Q9BSF8 BTBD10 PTHR21637:SF5 BTB/POZ DOMAIN-CONTAINING PROTEIN 10-RELATED BTB_POZ DOMAIN-CONTAINING PROTEIN 10 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=10805|UniProtKB=Q16586 Q16586 SGCA PTHR10132:SF16 ALPHA-/EPSILON-SARCOGLYCAN FAMILY MEMBER ALPHA-SARCOGLYCAN plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;dystrophin-associated glycoprotein complex#GO:0016010;membrane#GO:0016020;membrane protein complex#GO:0098796 cadherin#PC00057 HUMAN|HGNC=28580|UniProtKB=P59025 P59025 RTP1 PTHR14402:SF19 RECEPTOR TRANSPORTING PROTEIN RECEPTOR-TRANSPORTING PROTEIN 1 protein binding#GO:0005515;G protein-coupled receptor binding#GO:0001664;binding#GO:0005488;signaling receptor binding#GO:0005102 detection of chemical stimulus involved in sensory perception#GO:0050907;localization within membrane#GO:0051668;sensory perception#GO:0007600;detection of chemical stimulus involved in sensory perception of taste#GO:0050912;nervous system process#GO:0050877;localization#GO:0051179;cellular localization#GO:0051641;cellular component organization#GO:0016043;sensory perception of bitter taste#GO:0050913;detection of chemical stimulus#GO:0009593;response to stimulus#GO:0050896;protein targeting#GO:0006605;sensory perception of taste#GO:0050909;protein targeting to membrane#GO:0006612;sensory perception of chemical stimulus#GO:0007606;cellular component organization or biogenesis#GO:0071840;detection of chemical stimulus involved in sensory perception of bitter taste#GO:0001580;establishment of localization#GO:0051234;system process#GO:0003008;intracellular protein localization#GO:0008104;establishment of protein localization to membrane#GO:0090150;macromolecule localization#GO:0033036;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;establishment of protein localization#GO:0045184;cellular process#GO:0009987;response to chemical#GO:0042221;protein insertion into membrane#GO:0051205;multicellular organismal process#GO:0032501;membrane organization#GO:0061024 cell surface#GO:0009986;cellular anatomical structure#GO:0110165 membrane traffic protein#PC00150 HUMAN|HGNC=9056|UniProtKB=Q01970 Q01970 PLCB3 PTHR10336:SF11 PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN 1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3 calmodulin binding#GO:0005516;glycerophospholipase activity#GO:0004620;catalytic activity#GO:0003824;phospholipase activity#GO:0120569;hydrolase activity, acting on ester bonds#GO:0016788;phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578;binding#GO:0005488;lipase activity#GO:0016298;hydrolase activity#GO:0016787;protein binding#GO:0005515 cellular process#GO:0009987;release of sequestered calcium ion into cytosol#GO:0051209;signal transduction#GO:0007165;glycerophospholipid metabolic process#GO:0006650;monoatomic cation transmembrane transport#GO:0098655;metabolic process#GO:0008152;calcium ion transmembrane import into cytosol#GO:0097553;calcium ion transport#GO:0006816;phosphorus metabolic process#GO:0006793;calcium ion transmembrane transport#GO:0070588;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;glycerolipid metabolic process#GO:0046486;signaling#GO:0023052;G protein-coupled receptor signaling pathway#GO:0007186;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;organophosphate metabolic process#GO:0019637;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;transport#GO:0006810;phosphatidylinositol metabolic process#GO:0046488;lipid metabolic process#GO:0006629;establishment of localization#GO:0051234;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;phospholipid metabolic process#GO:0006644;metal ion transport#GO:0030001;monoatomic cation transport#GO:0006812;localization#GO:0051179;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 lipase#PC00143;phospholipase#PC00186;metabolite interconversion enzyme#PC00262;hydrolase#PC00121 Histamine H1 receptor mediated signaling pathway#P04385>PLC#P04484;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Phospholipase C-beta#P00744;Endothelin signaling pathway#P00019>PLCbeta#P00591;Endogenous cannabinoid signaling#P05730>PLC#P05746;5HT2 type receptor mediated signaling pathway#P04374>PLC#P04412;Angiotensin II-stimulated signaling through G proteins and beta-arrestin#P05911>PLC#P05933;Wnt signaling pathway#P00057>Phospholipase C#P01443;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PLCbetagamma#P00874;Oxytocin receptor mediated signaling pathway#P04391>PLC beta#P04530;2-arachidonoylglycerol biosynthesis#P05726>PLC#P05738;Alpha adrenergic receptor signaling pathway#P00002>PLC#P00073;Thyrotropin-releasing hormone receptor signaling pathway#P04394>PLC#P04581 HUMAN|HGNC=28557|UniProtKB=Q8IXV7 Q8IXV7 KLHDC8B PTHR46260:SF2 RING-TYPE DOMAIN-CONTAINING PROTEIN KELCH DOMAIN-CONTAINING PROTEIN 8B cellular process#GO:0009987;organelle organization#GO:0006996;chromosome segregation#GO:0007059;mitotic cell cycle process#GO:1903047;cellular component organization or biogenesis#GO:0071840;cell cycle process#GO:0022402;cell division#GO:0051301;mitotic nuclear division#GO:0140014;nuclear chromosome segregation#GO:0098813;cellular component organization#GO:0016043;cell cycle#GO:0007049;mitotic cytokinesis#GO:0000281;mitotic cell cycle#GO:0000278;cytokinetic process#GO:0032506;cytokinesis#GO:0000910;nuclear division#GO:0000280;mitotic cytokinetic process#GO:1902410;organelle fission#GO:0048285;cytoskeleton-dependent cytokinesis#GO:0061640 midbody#GO:0030496;membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;plasma membrane#GO:0005886 HUMAN|HGNC=10046|UniProtKB=P12724 P12724 RNASE3 PTHR11437:SF68 RIBONUCLEASE EOSINOPHIL CATIONIC PROTEIN nuclease activity#GO:0004518;RNA nuclease activity#GO:0004540;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;locomotion#GO:0040011;response to stimulus#GO:0050896;defense response to Gram-positive bacterium#GO:0050830;defense response to bacterium#GO:0042742;chemotaxis#GO:0006935;response to bacterium#GO:0009617;immune system process#GO:0002376;response to other organism#GO:0051707;response to chemical#GO:0042221;taxis#GO:0042330;defense response to other organism#GO:0098542;defense response to symbiont#GO:0140546;immune response#GO:0006955;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;response to external stimulus#GO:0009605;defense response#GO:0006952;innate immune response#GO:0045087 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031;endoribonuclease#PC00094 HUMAN|HGNC=28506|UniProtKB=Q8TBY9 Q8TBY9 CFAP251 PTHR13720:SF60 WD-40 REPEAT PROTEIN CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 251 plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;sperm flagellum#GO:0036126;cellular anatomical structure#GO:0110165;motile cilium#GO:0031514;organelle#GO:0043226;membrane-bounded organelle#GO:0043227;9+2 motile cilium#GO:0097729;cilium#GO:0005929 microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=9100|UniProtKB=O75051 O75051 PLXNA2 PTHR22625:SF37 PLEXIN PLEXIN-A2 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 positive regulation of cellular component organization#GO:0051130;animal gross anatomical part developmental process#GO:0160108;positive regulation of axonogenesis#GO:0050772;regulation of biological quality#GO:0065008;regulation of biological process#GO:0050789;regulation of multicellular organismal development#GO:2000026;positive regulation of multicellular organismal process#GO:0051240;regulation of cell shape#GO:0008360;negative regulation of biological process#GO:0048519;cell junction assembly#GO:0034329;cellular component organization#GO:0016043;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular component organization#GO:0051128;positive regulation of nervous system development#GO:0051962;synapse assembly#GO:0007416;positive regulation of cell differentiation#GO:0045597;cell surface receptor signaling pathway#GO:0007166;regulation of axonogenesis#GO:0050770;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;regulation of anatomical structure morphogenesis#GO:0022603;regulation of neuron projection development#GO:0010975;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;regulation of multicellular organismal process#GO:0051239;nervous system development#GO:0007399;positive regulation of cell development#GO:0010720;cellular component assembly#GO:0022607;synapse organization#GO:0050808;positive regulation of cell projection organization#GO:0031346;system development#GO:0048731;cell communication#GO:0007154;regulation of cell motility#GO:2000145;regulation of nervous system development#GO:0051960;anatomical structure development#GO:0048856;cellular response to stimulus#GO:0051716;regulation of neurogenesis#GO:0050767;regulation of developmental process#GO:0050793;positive regulation of neurogenesis#GO:0050769;cell junction organization#GO:0034330;regulation of cellular process#GO:0050794;regulation of cell migration#GO:0030334;developmental process#GO:0032502;positive regulation of developmental process#GO:0051094;regulation of cell differentiation#GO:0045595;regulation of cell projection organization#GO:0031344;negative regulation of cellular process#GO:0048523;regulation of plasma membrane bounded cell projection organization#GO:0120035;positive regulation of cellular process#GO:0048522;regulation of cell development#GO:0060284;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;negative regulation of cell adhesion#GO:0007162;regulation of cell adhesion#GO:0030155;multicellular organismal process#GO:0032501 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;signaling receptor complex#GO:0043235;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=586|UniProtKB=P13798 P13798 APEH PTHR42776:SF4 SERINE PEPTIDASE S9 FAMILY MEMBER ACYLAMINO-ACID-RELEASING ENZYME serine-type peptidase activity#GO:0008236;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096 serine protease#PC00203;protein modifying enzyme#PC00260 HUMAN|HGNC=4840|UniProtKB=P08631 P08631 HCK PTHR24418:SF245 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE HCK protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein binding#GO:0005515;non-membrane spanning protein tyrosine kinase activity#GO:0004715;binding#GO:0005488;signaling receptor binding#GO:0005102;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein tyrosine kinase activity#GO:0004713 developmental process#GO:0032502;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;cellular developmental process#GO:0048869;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell differentiation#GO:0030154;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 non-receptor tyrosine protein kinase#PC00168 Parkinson disease#P00049>Src kinase#P01230 HUMAN|HGNC=9844|UniProtKB=O60895 O60895 RAMP2 PTHR14076:SF9 RECEPTOR ACTIVITY MODIFYING PROTEIN RAMP RECEPTOR ACTIVITY-MODIFYING PROTEIN 2 coreceptor activity#GO:0015026;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 macromolecule localization#GO:0033036;multicellular organismal process#GO:0032501;tube development#GO:0035295;biological regulation#GO:0065007;transport#GO:0006810;developmental process#GO:0032502;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;receptor-mediated endocytosis#GO:0006898;protein localization to plasma membrane#GO:0072659;blood vessel development#GO:0001568;cellular response to stimulus#GO:0051716;tube morphogenesis#GO:0035239;regulation of cellular process#GO:0050794;metal ion transport#GO:0030001;localization within membrane#GO:0051668;anatomical structure development#GO:0048856;cell communication#GO:0007154;monoatomic cation transport#GO:0006812;localization#GO:0051179;system development#GO:0048731;response to hormone#GO:0009725;receptor internalization#GO:0031623;cellular process#GO:0009987;establishment of protein localization#GO:0045184;signal transduction#GO:0007165;vesicle-mediated transport#GO:0016192;response to chemical#GO:0042221;protein localization to cell periphery#GO:1990778;import into cell#GO:0098657;multicellular organism development#GO:0007275;anatomical structure formation involved in morphogenesis#GO:0048646;calcium ion transport#GO:0006816;vasculature development#GO:0001944;blood vessel morphogenesis#GO:0048514;response to endogenous stimulus#GO:0009719;protein localization to membrane#GO:0072657;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;cellular response to hormone stimulus#GO:0032870;endocytosis#GO:0006897;cellular response to endogenous stimulus#GO:0071495;circulatory system development#GO:0072359;response to stimulus#GO:0050896;signaling#GO:0023052;animal gross anatomical part developmental process#GO:0160108;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;cellular localization#GO:0051641;angiogenesis#GO:0001525;monoatomic ion transport#GO:0006811;protein transport#GO:0015031 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cell surface#GO:0009986;signaling receptor complex#GO:0043235 transmembrane signal receptor#PC00197 HUMAN|HGNC=27023|UniProtKB=A6NMZ7 A6NMZ7 COL6A6 PTHR22588:SF5 VWFA DOMAIN-CONTAINING PROTEIN COLLAGEN ALPHA-6(VI) CHAIN extracellular structure organization#GO:0043062;cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;external encapsulating structure organization#GO:0045229 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>EMC#P00863;Integrin signalling pathway#P00034>Collagen#P00922 HUMAN|HGNC=14660|UniProtKB=Q96KS0 Q96KS0 EGLN2 PTHR12907:SF6 EGL NINE HOMOLOG-RELATED PROLYL HYDROXYLASE EGLN2 catalytic activity#GO:0003824;ferrous iron binding#GO:0008198;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;iron ion binding#GO:0005506;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;oxidoreductase activity#GO:0016491;catalytic activity, acting on a protein#GO:0140096;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;transition metal ion binding#GO:0046914;metal ion binding#GO:0046872;dioxygenase activity#GO:0051213;cation binding#GO:0043169 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;response to decreased oxygen levels#GO:0036293;response to oxygen levels#GO:0070482;regulation of programmed cell death#GO:0043067;response to abiotic stimulus#GO:0009628;cellular response to hypoxia#GO:0071456;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;cellular response to stress#GO:0033554;response to chemical#GO:0042221;biological regulation#GO:0065007;regulation of neuron apoptotic process#GO:0043523;response to stress#GO:0006950;cellular process#GO:0009987;response to hypoxia#GO:0001666;regulation of apoptotic process#GO:0042981 nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 Hypoxia response via HIF activation#P00030>Prolyl Hydroxylase#P00821 HUMAN|HGNC=18607|UniProtKB=Q13433 Q13433 SLC39A6 PTHR12191:SF22 SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER ZIP6 transition metal ion transmembrane transporter activity#GO:0046915;symporter activity#GO:0015293;monoatomic cation transmembrane transporter activity#GO:0008324;zinc ion transmembrane transporter activity#GO:0005385;bicarbonate transmembrane transporter activity#GO:0015106;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873 transport#GO:0006810;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;cellular homeostasis#GO:0019725;inorganic cation import across plasma membrane#GO:0098659;intracellular chemical homeostasis#GO:0055082;import into cell#GO:0098657;establishment of localization#GO:0051234;cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801;zinc ion transport#GO:0006829;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;transition metal ion transport#GO:0000041;zinc ion transmembrane transport#GO:0071577;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;intracellular monoatomic ion homeostasis#GO:0006873;inorganic ion import across plasma membrane#GO:0099587;metal ion transport#GO:0030001;homeostatic process#GO:0042592;import across plasma membrane#GO:0098739 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227;secondary carrier transporter#PC00258 HUMAN|HGNC=17765|UniProtKB=Q8WVD3 Q8WVD3 RNF138 PTHR46968:SF2 E3 UBIQUITIN-PROTEIN LIGASE RNF138 E3 UBIQUITIN-PROTEIN LIGASE RNF138 binding#GO:0005488;nucleic acid binding#GO:0003676;acyltransferase activity#GO:0016746;single-stranded DNA binding#GO:0003697;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;DNA binding#GO:0003677;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 macromolecule metabolic process#GO:0043170;DNA double-strand break processing#GO:0000729;double-strand break repair#GO:0006302;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;DNA damage response#GO:0006974;DNA recombination#GO:0006310;nucleobase-containing compound metabolic process#GO:0006139;response to stress#GO:0006950;cellular process#GO:0009987;recombinational repair#GO:0000725;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;double-strand break repair via homologous recombination#GO:0000724;double-strand break repair via single-strand annealing#GO:0045002;cellular response to stimulus#GO:0051716 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;site of DNA damage#GO:0090734;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;site of double-strand break#GO:0035861;chromosome#GO:0005694 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=22235|UniProtKB=Q8NC69 Q8NC69 KCTD6 PTHR14499:SF149 POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD6 protein binding#GO:0005515;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;binding#GO:0005488 cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;catabolic process#GO:0009056;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 scaffold/adaptor protein#PC00226 HUMAN|HGNC=236|UniProtKB=O95622 O95622 ADCY5 PTHR45627:SF7 ADENYLATE CYCLASE TYPE 1 ADENYLATE CYCLASE TYPE 5 catalytic activity#GO:0003824;cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;lyase activity#GO:0016829;adenylate cyclase activity#GO:0004016 ribose phosphate biosynthetic process#GO:0046390;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;signal transduction#GO:0007165;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;cyclic purine nucleotide metabolic process#GO:0052652;response to stimulus#GO:0050896;small molecule metabolic process#GO:0044281;signaling#GO:0023052;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;regulation of biological process#GO:0050789;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;nucleotide biosynthetic process#GO:0009165;ribonucleotide metabolic process#GO:0009259;G protein-coupled receptor signaling pathway#GO:0007186;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;cyclic nucleotide biosynthetic process#GO:0009190;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;biosynthetic process#GO:0009058;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;carbohydrate derivative metabolic process#GO:1901135;nucleoside phosphate biosynthetic process#GO:1901293;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cyclic nucleotide metabolic process#GO:0009187;regulation of cellular process#GO:0050794;nucleoside phosphate metabolic process#GO:0006753;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;organophosphate biosynthetic process#GO:0090407;cell communication#GO:0007154 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 adenylate cyclase#PC00043 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>AC#P00841;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>cAMP cyclase#P00719;GABA-B receptor II signaling#P05731>AC#P05760;Endothelin signaling pathway#P00019>Adenylate cyclase#P00569 HUMAN|HGNC=20038|UniProtKB=Q9Y2R4 Q9Y2R4 DDX52 PTHR24031:SF594 RNA HELICASE ATP-DEPENDENT RNA HELICASE DDX52-RELATED macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;ribosomal small subunit biogenesis#GO:0042274;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;biosynthetic process#GO:0009058;maturation of SSU-rRNA#GO:0030490;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730 RNA metabolism protein#PC00031;RNA helicase#PC00032 HUMAN|HGNC=26839|UniProtKB=Q2M5E4 Q2M5E4 RGS21 PTHR10845:SF160 REGULATOR OF G PROTEIN SIGNALING REGULATOR OF G PROTEIN SIGNALING 21 molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;enzyme activator activity#GO:0008047 negative regulation of response to stimulus#GO:0048585;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;negative regulation of signal transduction#GO:0009968;negative regulation of biological process#GO:0048519;negative regulation of G protein-coupled receptor signaling pathway#GO:0045744;regulation of biological process#GO:0050789;negative regulation of cell communication#GO:0010648;negative regulation of signaling#GO:0023057;negative regulation of cellular process#GO:0048523;regulation of G protein-coupled receptor signaling pathway#GO:0008277;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051 plasma membrane#GO:0005886;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;cytoplasmic side of membrane#GO:0098562;membrane#GO:0016020;cytoplasmic side of plasma membrane#GO:0009898 GTPase-activating protein#PC00257 HUMAN|HGNC=11098|UniProtKB=P51531 P51531 SMARCA2 PTHR10799:SF541 SNF2/RAD54 HELICASE FAMILY SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 2 catalytic activity, acting on DNA#GO:0140097;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;DNA binding#GO:0003677;ATP-dependent activity, acting on DNA#GO:0008094;binding#GO:0005488;nucleic acid binding#GO:0003676;chromatin binding#GO:0003682;ATP-dependent activity#GO:0140657 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;chromatin organization#GO:0006325;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;epigenetic regulation of gene expression#GO:0040029;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;heterochromatin formation#GO:0031507;negative regulation of gene expression, epigenetic#GO:0045814;cellular component organization or biogenesis#GO:0071840;positive regulation of transcription by RNA polymerase II#GO:0045944;cellular component assembly#GO:0022607;positive regulation of macromolecule metabolic process#GO:0010604;heterochromatin organization#GO:0070828;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of transcription by RNA polymerase II#GO:0006357;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694 DNA helicase#PC00011;DNA metabolism protein#PC00009 Wnt signaling pathway#P00057>SWI/SNF#P01435 HUMAN|HGNC=23394|UniProtKB=Q5TZJ5 Q5TZJ5 SPATA31A1 PTHR21859:SF55 ACROSOME-SPECIFIC PROTEIN SPERMATOGENESIS-ASSOCIATED PROTEIN 31A1-RELATED HUMAN|HGNC=18777|UniProtKB=A0A8I5KTY6 A0A8I5KTY6 ZKSCAN8P1 PTHR14003:SF32 TRANSCRIPTIONAL REPRESSOR PROTEIN YY ZKSCAN8 PSEUDOGENE 1 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;transcription regulator complex#GO:0005667;intracellular anatomical structure#GO:0005622;chromosome#GO:0005694;chromatin#GO:0000785;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=26513|UniProtKB=Q96MF7 Q96MF7 NSMCE2 PTHR21330:SF1 E3 SUMO-PROTEIN LIGASE NSE2 E3 SUMO-PROTEIN LIGASE NSE2 ubiquitin-like protein transferase activity#GO:0019787;SUMO transferase activity#GO:0019789;SUMO ligase activity#GO:0061665;acyltransferase activity#GO:0016746;ubiquitin-like protein ligase activity#GO:0061659;transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein modification by small protein conjugation#GO:0032446;double-strand break repair via homologous recombination#GO:0000724;cellular response to stimulus#GO:0051716;nucleic acid metabolic process#GO:0090304;protein modification process#GO:0036211;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;protein modification by small protein conjugation or removal#GO:0070647;recombinational repair#GO:0000725;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;cellular process#GO:0009987;response to stress#GO:0006950;nucleobase-containing compound metabolic process#GO:0006139;post-translational protein modification#GO:0043687;DNA damage response#GO:0006974;DNA recombination#GO:0006310;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;protein sumoylation#GO:0016925;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170 intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634;chromosome#GO:0005694;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;transferase complex#GO:1990234;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;condensed chromosome#GO:0000793 HUMAN|HGNC=9251|UniProtKB=P10619 P10619 CTSA PTHR11802:SF502 SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE LYSOSOMAL PROTECTIVE PROTEIN catalytic activity#GO:0003824;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;serine-type peptidase activity#GO:0008236;serine hydrolase activity#GO:0017171;carboxypeptidase activity#GO:0004180;hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238 serine protease#PC00203 HUMAN|HGNC=1434|UniProtKB=P05937 P05937 CALB1 PTHR19972:SF14 CALBINDIN CALBINDIN cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167 cytoplasm#GO:0005737;somatodendritic compartment#GO:0036477;cytosol#GO:0005829;nucleus#GO:0005634;presynapse#GO:0098793;neuron projection#GO:0043005;cell junction#GO:0030054;axon terminus#GO:0043679;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;distal axon#GO:0150034;terminal bouton#GO:0043195;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;neuron projection terminus#GO:0044306;cell projection#GO:0042995;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;dendrite#GO:0030425;axon#GO:0030424;intracellular organelle#GO:0043229;dendritic tree#GO:0097447 calmodulin-related#PC00061 HUMAN|HGNC=43618|UniProtKB=A8MWK0 A8MWK0 FADS2B PTHR19353:SF22 FATTY ACID DESATURASE 2 FATTY ACID DESATURASE 2-LIKE PROTEIN FADS2B-RELATED oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705 lipid metabolic process#GO:0006629;cellular process#GO:0009987;primary metabolic process#GO:0044238;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;membrane#GO:0016020 oxidoreductase#PC00176 HUMAN|HGNC=29367|UniProtKB=Q86VY4 Q86VY4 TSPYL5 PTHR11875:SF30 TESTIS-SPECIFIC Y-ENCODED PROTEIN TESTIS-SPECIFIC Y-ENCODED-LIKE PROTEIN 5 protein binding#GO:0005515;binding#GO:0005488;histone binding#GO:0042393;chromatin binding#GO:0003682 chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=11446|UniProtKB=O00186 O00186 STXBP3 PTHR11679:SF33 VESICLE PROTEIN SORTING-ASSOCIATED SYNTAXIN-BINDING PROTEIN 3 binding#GO:0005488;SNARE binding#GO:0000149;protein binding#GO:0005515;syntaxin binding#GO:0019905 neurotransmitter secretion#GO:0007269;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;macromolecule localization#GO:0033036;vesicle localization#GO:0051648;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;calcium-ion regulated exocytosis#GO:0017156;synaptic vesicle cycle#GO:0099504;transport#GO:0006810;anterograde trans-synaptic signaling#GO:0098916;signal release from synapse#GO:0099643;chemical synaptic transmission#GO:0007268;secretion#GO:0046903;localization#GO:0051179;cell communication#GO:0007154;organelle localization#GO:0051640;trans-synaptic signaling#GO:0099537;signal release#GO:0023061;vesicle-mediated transport#GO:0016192;neurotransmitter transport#GO:0006836;establishment of vesicle localization#GO:0051650;synaptic signaling#GO:0099536;cellular process#GO:0009987;synaptic vesicle exocytosis#GO:0016079;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;vesicle-mediated transport in synapse#GO:0099003;exocytosis#GO:0006887;regulated exocytosis#GO:0045055;intracellular protein transport#GO:0006886;establishment of organelle localization#GO:0051656;signaling#GO:0023052;export from cell#GO:0140352;regulation of biological process#GO:0050789;cellular localization#GO:0051641;protein transport#GO:0015031;secretion by cell#GO:0032940 membrane#GO:0016020;secretory vesicle#GO:0099503;cell periphery#GO:0071944;endomembrane system#GO:0012505;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=25289|UniProtKB=Q8IY82 Q8IY82 DRC7 PTHR35249:SF2 DYNEIN REGULATORY COMPLEX SUBUNIT 7 DYNEIN REGULATORY COMPLEX SUBUNIT 7 cilium-dependent cell motility#GO:0060285;microtubule-based process#GO:0007017;flagellated sperm motility#GO:0030317;cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;cell motility#GO:0048870;microtubule-based movement#GO:0007018;reproductive process#GO:0022414;cilium movement involved in cell motility#GO:0060294;sperm motility#GO:0097722;cellular process#GO:0009987 cilium#GO:0005929;cellular anatomical structure#GO:0110165;motile cilium#GO:0031514;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995 microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=2852|UniProtKB=P52429 P52429 DGKE PTHR11255:SF54 DIACYLGLYCEROL KINASE DIACYLGLYCEROL KINASE EPSILON transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;lipid kinase activity#GO:0001727;phosphotransferase activity, alcohol group as acceptor#GO:0016773 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;biological regulation#GO:0065007;signaling#GO:0023052;glycerolipid metabolic process#GO:0046486;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238 membrane#GO:0016020;cellular anatomical structure#GO:0110165 kinase#PC00137;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=29250|UniProtKB=Q9P2L0 Q9P2L0 WDR35 PTHR16517:SF1 TUBBY-RELATED WD REPEAT-CONTAINING PROTEIN 35 microtubule-based transport#GO:0099111;organelle assembly#GO:0070925;cilium organization#GO:0044782;cellular localization#GO:0051641;localization#GO:0051179;cellular component organization#GO:0016043;cilium assembly#GO:0060271;intraciliary transport#GO:0042073;microtubule-based movement#GO:0007018;intraciliary retrograde transport#GO:0035721;cell projection organization#GO:0030030;transport#GO:0006810;intracellular transport#GO:0046907;plasma membrane bounded cell projection assembly#GO:0120031;microtubule-based process#GO:0007017;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;cell projection assembly#GO:0030031;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton-dependent intracellular transport#GO:0030705;cellular component assembly#GO:0022607 cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;cilium#GO:0005929;intraciliary transport particle#GO:0030990;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;axoneme#GO:0005930;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;ciliary plasm#GO:0097014;cytoskeleton#GO:0005856;intraciliary transport particle A#GO:0030991;membraneless organelle#GO:0043228 scaffold/adaptor protein#PC00226 HUMAN|HGNC=23172|UniProtKB=Q8N699 Q8N699 MYCT1 PTHR14869:SF0 MYC TARGET PROTEIN 1 MYC TARGET PROTEIN 1 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233 HUMAN|HGNC=11247|UniProtKB=O43291 O43291 SPINT2 PTHR47247:SF1 KUNITZ-TYPE PROTEASE INHIBITOR 2 KUNITZ-TYPE PROTEASE INHIBITOR 2 endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772;enzyme inhibitor activity#GO:0004857;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;serine-type endopeptidase inhibitor activity#GO:0004867;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;peptidase regulator activity#GO:0061134 cell development#GO:0048468;cell morphogenesis#GO:0000902;epithelial cell differentiation#GO:0030855;tissue development#GO:0009888;epithelium development#GO:0060429;cell differentiation#GO:0030154;cellular process#GO:0009987;anatomical structure morphogenesis#GO:0009653;cellular developmental process#GO:0048869;anatomical structure development#GO:0048856;developmental process#GO:0032502;animal gross anatomical part developmental process#GO:0160108;establishment or maintenance of cell polarity#GO:0007163 protease inhibitor#PC00191 HUMAN|HGNC=6564|UniProtKB=Q08380 Q08380 LGALS3BP PTHR24410:SF16 HL07962P-RELATED GALECTIN-3-BINDING PROTEIN defense/immunity protein#PC00090 HUMAN|HGNC=706|UniProtKB=O15145 O15145 ARPC3 PTHR12391:SF10 ARP2/3 COMPLEX 21 KD SUBUNIT ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 3 actin binding#GO:0003779;actin filament binding#GO:0051015;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 cytoskeleton organization#GO:0007010;actin nucleation#GO:0045010;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987;Arp2/3 complex-mediated actin nucleation#GO:0034314;cellular component organization#GO:0016043;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;Arp2/3 protein complex#GO:0005885;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;actin cytoskeleton#GO:0015629 actin or actin-binding cytoskeletal protein#PC00041;cytoskeletal protein#PC00085 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Arp2/3#P00876;Cytoskeletal regulation by Rho GTPase#P00016>ARP2/3#P00511;Integrin signalling pathway#P00034>Arp2/3#P00912 HUMAN|HGNC=30836|UniProtKB=Q8TC44 Q8TC44 POC1B PTHR44019:SF1 WD REPEAT-CONTAINING PROTEIN 55 POC1 CENTRIOLAR PROTEIN HOMOLOG B plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cell projection organization#GO:0030030;cellular process#GO:0009987;cell projection assembly#GO:0030031;cilium assembly#GO:0060271;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cilium organization#GO:0044782;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection assembly#GO:0120031;organelle assembly#GO:0070925 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;cilium#GO:0005929;intracellular organelle#GO:0043229;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;plasma membrane bounded cell projection#GO:0120025;centriole#GO:0005814;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;microtubule cytoskeleton#GO:0015630 non-motor microtubule binding protein#PC00166;cytoskeletal protein#PC00085 HUMAN|HGNC=11756|UniProtKB=Q03403 Q03403 TFF2 PTHR13826:SF17 INTESTINAL TREFOIL FACTOR-RELATED TREFOIL FACTOR 2 digestion#GO:0007586;anatomical structure homeostasis#GO:0060249;multicellular organismal process#GO:0032501;homeostatic process#GO:0042592;epithelial structure maintenance#GO:0010669;system process#GO:0003008;tissue homeostasis#GO:0001894;multicellular organismal-level homeostasis#GO:0048871 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 CCKR signaling map#P06959>TFF2#G07264;CCKR signaling map#P06959>TFF2#G06971 HUMAN|HGNC=17929|UniProtKB=Q8N5Z0 Q8N5Z0 AADAT PTHR42790:SF24 AMINOTRANSFERASE KYNURENINE_ALPHA-AMINOADIPATE AMINOTRANSFERASE, MITOCHONDRIAL transaminase activity#GO:0008483;transferase activity#GO:0016740;catalytic activity#GO:0003824 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739 transaminase#PC00216 HUMAN|HGNC=5119|UniProtKB=P17481 P17481 HOXB8 PTHR46166:SF2 HOMEOBOX DOMAIN-CONTAINING PROTEIN HOMEOBOX PROTEIN HOX-B8 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 homeodomain transcription factor#PC00119 HUMAN|HGNC=13179|UniProtKB=Q9H2S9 Q9H2S9 IKZF4 PTHR24404:SF28 ZINC FINGER PROTEIN ZINC FINGER PROTEIN EOS sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 DNA-binding transcription factor#PC00218;zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=21366|UniProtKB=Q4VXA5 Q4VXA5 KHDC1 PTHR31368:SF6 DEVELOPMENT PLURPOTENCY-ASSOCIATED PROTEIN 1/5 FAMILY MEMBER KH HOMOLOGY DOMAIN-CONTAINING PROTEIN 1 nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=23250|UniProtKB=Q6ZPD8 Q6ZPD8 DGAT2L6 PTHR12317:SF19 DIACYLGLYCEROL O-ACYLTRANSFERASE DIACYLGLYCEROL O-ACYLTRANSFERASE 2-LIKE PROTEIN 6 acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746 acylglycerol metabolic process#GO:0006639;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;triglyceride metabolic process#GO:0006641;neutral lipid metabolic process#GO:0006638;primary metabolic process#GO:0044238;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;lipid biosynthetic process#GO:0008610;glycerolipid metabolic process#GO:0046486;triglyceride biosynthetic process#GO:0019432;biosynthetic process#GO:0009058 organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020 transferase#PC00220;acyltransferase#PC00042 HUMAN|HGNC=21332|UniProtKB=Q86UX6 Q86UX6 STK32C PTHR24356:SF153 SERINE/THREONINE-PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE 32C kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=8826|UniProtKB=Q9GZU2 Q9GZU2 PEG3 PTHR24381:SF293 ZINC FINGER PROTEIN PATERNALLY-EXPRESSED GENE 3 PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=27893|UniProtKB=P0DXC3 P0DXC3 NPIPA6 PTHR15438:SF5 NUCLEAR PORE COMPLEX INTERACTING PROTEIN NUCLEAR PORE COMPLEX INTERACTING PROTEIN FAMILY MEMBER B3-RELATED HUMAN|HGNC=21062|UniProtKB=O95363 O95363 FARS2 PTHR11538:SF41 PHENYLALANYL-TRNA SYNTHETASE PHENYLALANINE--TRNA LIGASE, MITOCHONDRIAL catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;ligase activity#GO:0016874 tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;amino acid activation#GO:0043038;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;tRNA aminoacylation for protein translation#GO:0006418;tRNA aminoacylation#GO:0043039;amino acid metabolic process#GO:0006520;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;translation#GO:0006412;RNA metabolic process#GO:0016070;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;protein biosynthetic process#GO:0160307 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 aminoacyl-tRNA synthetase#PC00047 HUMAN|HGNC=11186|UniProtKB=Q99523 Q99523 SORT1 PTHR12106:SF23 SORTILIN RELATED SORTILIN Golgi to endosome transport#GO:0006895;cellular component organization#GO:0016043;cytosolic transport#GO:0016482;endocytosis#GO:0006897;post-Golgi vesicle-mediated transport#GO:0006892;cellular localization#GO:0051641;localization#GO:0051179;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;organelle organization#GO:0006996;vesicle-mediated transport#GO:0016192;Golgi vesicle transport#GO:0048193;transport#GO:0006810;intracellular transport#GO:0046907;vesicle organization#GO:0016050;establishment of localization#GO:0051234;import into cell#GO:0098657;cellular component organization or biogenesis#GO:0071840 membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 membrane traffic protein#PC00150 HUMAN|HGNC=3725|UniProtKB=O95302 O95302 FKBP9 PTHR46046:SF2 PEPTIDYLPROLYL ISOMERASE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP9 HUMAN|HGNC=12928|UniProtKB=P52747 P52747 ZNF143 PTHR24388:SF55 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 143 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=12588|UniProtKB=P0C7P4 P0C7P4 UQCRFS1P1 PTHR10134:SF50 CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL-RELATED oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 ATP synthesis coupled electron transport#GO:0042773;oxidative phosphorylation#GO:0006119;cellular respiration#GO:0045333;energy derivation by oxidation of organic compounds#GO:0015980;aerobic respiration#GO:0009060;metabolic process#GO:0008152;aerobic electron transport chain#GO:0019646;generation of precursor metabolites and energy#GO:0006091;electron transport chain#GO:0022900;mitochondrial electron transport, ubiquinol to cytochrome c#GO:0006122;mitochondrial ATP synthesis coupled electron transport#GO:0042775;respiratory electron transport chain#GO:0022904;cellular process#GO:0009987 respiratory chain complex#GO:0098803;cytochrome complex#GO:0070069;cell periphery#GO:0071944;membrane protein complex#GO:0098796;oxidoreductase complex#GO:1990204;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;respiratory chain complex III#GO:0045275;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351 HUMAN|HGNC=11598|UniProtKB=Q9UMR3 Q9UMR3 TBX20 PTHR11267:SF210 T-BOX PROTEIN-RELATED T-BOX TRANSCRIPTION FACTOR TBX20 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690 anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;tissue morphogenesis#GO:0048729;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;embryonic organ development#GO:0048568;pattern specification process#GO:0007389;regulation of cellular process#GO:0050794;animal organ morphogenesis#GO:0009887;regulation of macromolecule metabolic process#GO:0060255;tube morphogenesis#GO:0035239;heart morphogenesis#GO:0003007;determination of left/right symmetry#GO:0007368;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;specification of symmetry#GO:0009799;developmental process#GO:0032502;tissue development#GO:0009888;multicellular organismal process#GO:0032501;regionalization#GO:0003002;regulation of nucleobase-containing compound metabolic process#GO:0019219;epithelium development#GO:0060429;tube development#GO:0035295;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cell fate commitment#GO:0045165;animal gross anatomical part developmental process#GO:0160108;cell differentiation#GO:0030154;circulatory system development#GO:0072359;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;animal organ development#GO:0048513;embryonic morphogenesis#GO:0048598;multicellular organism development#GO:0007275;morphogenesis of an epithelium#GO:0002009;cell fate specification#GO:0001708;left/right pattern formation#GO:0060972;heart development#GO:0007507;determination of bilateral symmetry#GO:0009855;embryo development#GO:0009790;cellular process#GO:0009987 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694;chromatin#GO:0000785;nucleus#GO:0005634 Rel homology transcription factor#PC00252;immunoglobulin fold transcription factor#PC00251 HUMAN|HGNC=6821|UniProtKB=P33908 P33908 MAN1A1 PTHR11742:SF31 MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE IA hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787 macromolecule metabolic process#GO:0043170;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;proteasomal protein catabolic process#GO:0010498;response to chemical#GO:0042221;cellular process#GO:0009987;response to stress#GO:0006950;ERAD pathway#GO:0036503;protein metabolic process#GO:0019538;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;response to endoplasmic reticulum stress#GO:0034976;catabolic process#GO:0009056;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238 intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020 protein modifying enzyme#PC00260 HUMAN|HGNC=51375|UniProtKB=P0DMS9 P0DMS9 TMIGD3 PTHR11860:SF4 POLYMERIC-IMMUNOGLOBULIN RECEPTOR TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN TMIGD3 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 immune response-regulating signaling pathway#GO:0002764;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;response to stimulus#GO:0050896;signaling#GO:0023052;immune system process#GO:0002376;regulation of immune response#GO:0050776;cell communication#GO:0007154;positive regulation of immune system process#GO:0002684;cellular process#GO:0009987;activation of immune response#GO:0002253;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;immune response-activating signaling pathway#GO:0002757 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=13101|UniProtKB=P17029 P17029 ZKSCAN1 PTHR23226:SF94 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER PROTEIN WITH KRAB AND SCAN DOMAINS 1 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=11989|UniProtKB=P11388 P11388 TOP2A PTHR10169:SF61 DNA TOPOISOMERASE/GYRASE DNA TOPOISOMERASE 2-ALPHA isomerase activity#GO:0016853;catalytic activity, acting on DNA#GO:0140097;macromolecular conformation isomerase activity#GO:0120543;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;ATP-dependent activity, acting on DNA#GO:0008094;ATP-dependent activity#GO:0140657 cellular component organization or biogenesis#GO:0071840;meiotic cell cycle#GO:0051321;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;chromosome segregation#GO:0007059;DNA recombination#GO:0006310;organelle organization#GO:0006996;cellular process#GO:0009987;cellular component disassembly#GO:0022411;chromosome condensation#GO:0030261;nuclear division#GO:0000280;reciprocal meiotic recombination#GO:0007131;sister chromatid segregation#GO:0000819;meiosis I#GO:0007127;nuclear chromosome segregation#GO:0098813;cellular component organization#GO:0016043;meiotic cell cycle process#GO:1903046;execution phase of apoptosis#GO:0097194;apoptotic process#GO:0006915;cell cycle process#GO:0022402;macromolecule metabolic process#GO:0043170;meiotic nuclear division#GO:0140013;chromosome organization#GO:0051276;nucleobase-containing compound metabolic process#GO:0006139;resolution of meiotic recombination intermediates#GO:0000712;organelle fission#GO:0048285;meiosis I cell cycle process#GO:0061982;sexual reproduction#GO:0019953;reproductive process#GO:0022414;homologous recombination#GO:0035825;cell cycle#GO:0007049;nucleic acid metabolic process#GO:0090304;programmed cell death#GO:0012501;primary metabolic process#GO:0044238;reciprocal homologous recombination#GO:0140527;cell death#GO:0008219 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;nucleus#GO:0005634;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 DNA metabolism protein#PC00009 DNA replication#P00017>Top#P00530;DNA replication#P00017>DNA Topisomerase#P00536 HUMAN|HGNC=29446|UniProtKB=Q9H4I8 Q9H4I8 SERHL2 PTHR43329:SF4 EPOXIDE HYDROLASE SERINE HYDROLASE-LIKE PROTEIN-RELATED hydrolase activity#GO:0016787;catalytic activity#GO:0003824 hydrolase#PC00121 HUMAN|HGNC=13635|UniProtKB=Q9BX97 Q9BX97 PLVAP PTHR21687:SF5 PLASMALEMMA VESICLE-ASSOCIATED PROTEIN PLASMALEMMA VESICLE-ASSOCIATED PROTEIN positive regulation of locomotion#GO:0040017;system process#GO:0003008;regulation of cell migration#GO:0030334;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;blood circulation#GO:0008015;multicellular organismal process#GO:0032501;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of cell migration#GO:0030335;positive regulation of immune system process#GO:0002684;regulation of biological quality#GO:0065008;regulation of cell motility#GO:2000145;circulatory system process#GO:0003013;regulation of leukocyte migration#GO:0002685;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;positive regulation of cell motility#GO:2000147 HUMAN|HGNC=26183|UniProtKB=Q6DN14 Q6DN14 MCTP1 PTHR45911:SF3 C2 DOMAIN-CONTAINING PROTEIN MULTIPLE C2 AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 1 ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;calcium ion binding#GO:0005509;metal ion binding#GO:0046872;cation binding#GO:0043169 regulation of biological process#GO:0050789;biological regulation#GO:0065007;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of trans-synaptic signaling#GO:0099177;regulation of neurotransmitter secretion#GO:0046928;regulation of signaling#GO:0023051;regulation of neurotransmitter transport#GO:0051588;regulation of transport#GO:0051049;regulation of localization#GO:0032879;regulation of secretion by cell#GO:1903530;regulation of secretion#GO:0051046 intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;synaptic vesicle#GO:0008021;synaptic vesicle membrane#GO:0030672;vesicle#GO:0031982;cell junction#GO:0030054;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;transport vesicle membrane#GO:0030658;transport vesicle#GO:0030133;cytoplasm#GO:0005737;membrane#GO:0016020;secretory vesicle#GO:0099503;vesicle membrane#GO:0012506;presynapse#GO:0098793 HUMAN|HGNC=28338|UniProtKB=Q6ZUT9 Q6ZUT9 DENND5B PTHR46070:SF3 PINSTRIPE, ISOFORM A DENN DOMAIN-CONTAINING PROTEIN 5B binding#GO:0005488;guanyl-nucleotide exchange factor activity#GO:0005085;enzyme binding#GO:0019899;protein binding#GO:0005515;enzyme regulator activity#GO:0030234;small GTPase binding#GO:0031267;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function regulator activity#GO:0098772 HUMAN|HGNC=29578|UniProtKB=Q6IQ19 Q6IQ19 CCSAP PTHR31022:SF4 CENTRIOLE, CILIA AND SPINDLE-ASSOCIATED PROTEIN CENTRIOLE, CILIA AND SPINDLE-ASSOCIATED PROTEIN protein binding#GO:0005515;microtubule binding#GO:0008017;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631 regulation of microtubule cytoskeleton organization#GO:0070507;regulation of cell cycle process#GO:0010564;biological regulation#GO:0065007;regulation of organelle assembly#GO:1902115;regulation of mitotic spindle assembly#GO:1901673;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;regulation of spindle organization#GO:0090224;regulation of cellular component biogenesis#GO:0044087;regulation of cell cycle#GO:0051726;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of mitotic spindle organization#GO:0060236;regulation of spindle assembly#GO:0090169;regulation of microtubule-based process#GO:0032886 axoneme#GO:0005930;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ciliary transition zone#GO:0035869;cilium#GO:0005929;intracellular organelle#GO:0043229;axon#GO:0030424;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;membraneless organelle#GO:0043228;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;spindle#GO:0005819;ciliary plasm#GO:0097014;cytoplasm#GO:0005737;centriole#GO:0005814;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;neuron projection#GO:0043005 HUMAN|HGNC=1724|UniProtKB=Q9UJX2 Q9UJX2 CDC23 PTHR12558:SF10 CELL DIVISION CYCLE 16,23,27 CELL DIVISION CYCLE PROTEIN 23 HOMOLOG molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;enzyme-substrate adaptor activity#GO:0140767 regulation of cell cycle phase transition#GO:1901987;primary metabolic process#GO:0044238;protein modification process#GO:0036211;modification-dependent protein catabolic process#GO:0019941;cell division#GO:0051301;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;positive regulation of cellular process#GO:0048522;regulation of mitotic cell cycle#GO:0007346;regulation of mitotic metaphase/anaphase transition#GO:0030071;biological regulation#GO:0065007;post-translational protein modification#GO:0043687;regulation of nuclear division#GO:0051783;regulation of chromosome organization#GO:0033044;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule metabolic process#GO:0043170;regulation of mitotic sister chromatid separation#GO:0010965;regulation of mitotic nuclear division#GO:0007088;positive regulation of mitotic cell cycle#GO:0045931;ubiquitin-dependent protein catabolic process#GO:0006511;regulation of biological process#GO:0050789;protein modification by small protein conjugation#GO:0032446;positive regulation of cell cycle process#GO:0090068;regulation of organelle organization#GO:0033043;regulation of cellular component organization#GO:0051128;regulation of cell cycle#GO:0051726;regulation of sister chromatid segregation#GO:0033045;protein modification by small protein conjugation or removal#GO:0070647;anaphase-promoting complex-dependent catabolic process#GO:0031145;protein catabolic process#GO:0030163;positive regulation of cellular component organization#GO:0051130;modification-dependent macromolecule catabolic process#GO:0043632;regulation of mitotic cell cycle phase transition#GO:1901990;positive regulation of organelle organization#GO:0010638;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of chromosome separation#GO:1905818;protein ubiquitination#GO:0016567;regulation of cell cycle process#GO:0010564;proteasomal protein catabolic process#GO:0010498;positive regulation of cell cycle#GO:0045787;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;regulation of chromosome segregation#GO:0051983;positive regulation of mitotic nuclear division#GO:0045840 cellular anatomical structure#GO:0110165;nuclear ubiquitin ligase complex#GO:0000152;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cullin-RING ubiquitin ligase complex#GO:0031461;ubiquitin ligase complex#GO:0000151;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;anaphase-promoting complex#GO:0005680;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=19339|UniProtKB=Q9NSY0 Q9NSY0 NRBP2 PTHR13902:SF53 SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED NUCLEAR RECEPTOR-BINDING PROTEIN 2 catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674 regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;response to stimulus#GO:0050896;signaling#GO:0023052;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;anatomical structure development#GO:0048856;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;neurogenesis#GO:0022008;developmental process#GO:0032502;neuron differentiation#GO:0030182 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=25397|UniProtKB=Q6MZP7 Q6MZP7 LIN54 PTHR12446:SF36 TESMIN/TSO1-RELATED PROTEIN LIN-54 HOMOLOG biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=14824|UniProtKB=Q8NGG4 Q8NGG4 OR8H1 PTHR48018:SF181 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 8H1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 signaling#GO:0023052;regulation of cellular process#GO:0050794;sensory perception of smell#GO:0007608;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cell communication#GO:0007154;nervous system process#GO:0050877;sensory perception#GO:0007600;G protein-coupled receptor signaling pathway#GO:0007186;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;cellular process#GO:0009987;signal transduction#GO:0007165;system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=32175|UniProtKB=P0DV77 P0DV77 TPRX2 PTHR45793:SF21 HOMEOBOX PROTEIN TETRAPEPTIDE REPEAT HOMEOBOX PROTEIN 2 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=3073|UniProtKB=Q16829 Q16829 DUSP7 PTHR10159:SF305 DUAL SPECIFICITY PROTEIN PHOSPHATASE DUAL SPECIFICITY PROTEIN PHOSPHATASE 7 protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;protein tyrosine/serine/threonine phosphatase activity#GO:0008138;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096 negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;cell communication#GO:0007154;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;negative regulation of MAPK cascade#GO:0043409;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of cell communication#GO:0010646;negative regulation of cellular process#GO:0048523;regulation of MAPK cascade#GO:0043408;regulation of response to stimulus#GO:0048583;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of ERK1 and ERK2 cascade#GO:0070372;negative regulation of ERK1 and ERK2 cascade#GO:0070373;negative regulation of response to stimulus#GO:0048585;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 protein phosphatase#PC00195 Oxidative stress response#P00046>MKP5#P01131 HUMAN|HGNC=477|UniProtKB=P04746 P04746 AMY2A PTHR43447:SF50 ALPHA-AMYLASE ALPHA-AMYLASE 1A-RELATED extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 amylase#PC00048 HUMAN|HGNC=26423|UniProtKB=Q86XE0 Q86XE0 SNX32 PTHR45850:SF3 SORTING NEXIN FAMILY MEMBER SORTING NEXIN-32 intracellular transport#GO:0046907;transport#GO:0006810;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;endosomal transport#GO:0016197;retrograde transport, endosome to Golgi#GO:0042147;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;cytosolic transport#GO:0016482 intracellular vesicle#GO:0097708;vesicle#GO:0031982;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227 scaffold/adaptor protein#PC00226 HUMAN|HGNC=12305|UniProtKB=Q15643 Q15643 TRIP11 PTHR18921:SF2 MYOSIN HEAVY CHAIN - RELATED THYROID RECEPTOR-INTERACTING PROTEIN 11 binding#GO:0005488;enzyme binding#GO:0019899;small GTPase binding#GO:0031267;protein binding#GO:0005515 endomembrane system organization#GO:0010256;vesicle-mediated transport#GO:0016192;Golgi organization#GO:0007030;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular component organization or biogenesis#GO:0071840;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;transport#GO:0006810;Golgi vesicle transport#GO:0048193;intracellular transport#GO:0046907 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 actin or actin-binding cytoskeletal protein#PC00041;actin binding motor protein#PC00040 HUMAN|HGNC=33106|UniProtKB=Q68DY9 Q68DY9 ZNF772 PTHR24377:SF610 IP01015P-RELATED ZINC FINGER PROTEIN 772 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=16492|UniProtKB=Q86V87 Q86V87 FHIP2B PTHR21705:SF9 RAI16 PROTEIN-RELATED FHF COMPLEX SUBUNIT HOOK-INTERACTING PROTEIN 2B HUMAN|HGNC=30596|UniProtKB=Q86VD9 Q86VD9 PIGZ PTHR22760:SF3 GLYCOSYLTRANSFERASE GPI ALPHA-1,2-MANNOSYLTRANSFERASE 4 glycosyltransferase activity#GO:0016757;mannosyltransferase activity#GO:0000030;transferase activity#GO:0016740;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycerophospholipid biosynthetic process#GO:0046474;GPI anchor metabolic process#GO:0006505;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;glycerolipid biosynthetic process#GO:0045017;organophosphate metabolic process#GO:0019637;biosynthetic process#GO:0009058;glycerophospholipid metabolic process#GO:0006650;GPI anchor biosynthetic process#GO:0006506;lipid biosynthetic process#GO:0008610;gene expression#GO:0010467;protein maturation#GO:0051604;glycolipid biosynthetic process#GO:0009247;organophosphate biosynthetic process#GO:0090407;protein metabolic process#GO:0019538;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phospholipid metabolic process#GO:0006644;glycerolipid metabolic process#GO:0046486;GPI anchored protein biosynthesis#GO:0180046;liposaccharide metabolic process#GO:1903509;phospholipid biosynthetic process#GO:0008654;glycolipid metabolic process#GO:0006664 membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090 glycosyltransferase#PC00111 HUMAN|HGNC=17910|UniProtKB=Q9UI38 Q9UI38 PRSS50 PTHR24253:SF35 TRANSMEMBRANE PROTEASE SERINE THREONINE PROTEASE PRSS50-RELATED catalytic activity#GO:0003824;serine-type peptidase activity#GO:0008236;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;serine hydrolase activity#GO:0017171 protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;protein processing#GO:0016485;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;proteolysis#GO:0006508;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 serine protease#PC00203;protease#PC00190;protein modifying enzyme#PC00260 HUMAN|HGNC=9599|UniProtKB=O14684 O14684 PTGES PTHR10689:SF9 MICROSOMAL GLUTATHIONE S-TRANSFERASE 1 PROSTAGLANDIN E SYNTHASE intramolecular oxidoreductase activity#GO:0016860;isomerase activity#GO:0016853;catalytic activity#GO:0003824 small molecule metabolic process#GO:0044281;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid biosynthetic process#GO:0046394;oxoacid metabolic process#GO:0043436;prostaglandin metabolic process#GO:0006693;icosanoid metabolic process#GO:0006690;lipid biosynthetic process#GO:0008610;unsaturated fatty acid biosynthetic process#GO:0006636;icosanoid biosynthetic process#GO:0046456;fatty acid biosynthetic process#GO:0006633;biosynthetic process#GO:0009058;cellular process#GO:0009987;monocarboxylic acid biosynthetic process#GO:0072330;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;unsaturated fatty acid metabolic process#GO:0033559 cellular anatomical structure#GO:0110165;membrane#GO:0016020 metabolite interconversion enzyme#PC00262;transferase#PC00220 HUMAN|HGNC=10897|UniProtKB=P12757 P12757 SKIL PTHR10005:SF3 SKI ONCOGENE-RELATED SKI-LIKE PROTEIN transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;protein binding#GO:0005515;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of cell communication#GO:0010648;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of signal transduction#GO:0009968;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092;regulation of transforming growth factor beta receptor signaling pathway#GO:0017015;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of DNA-templated transcription#GO:0006355;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;regulation of BMP signaling pathway#GO:0030510;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of response to stimulus#GO:0048585;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular response to growth factor stimulus#GO:0090287;regulation of signal transduction#GO:0009966;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of biosynthetic process#GO:0009889;negative regulation of BMP signaling pathway#GO:0030514;regulation of gene expression#GO:0010468 membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 TGF-beta signaling pathway#P00052>Co-activators corepressors#P01282;Gonadotropin-releasing hormone receptor pathway#P06664>SKIL#P06858 HUMAN|HGNC=7463|UniProtKB=P48039 P48039 MTNR1A PTHR24228:SF53 B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR MELATONIN RECEPTOR TYPE 1A signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway#GO:0007193;cell communication#GO:0007154 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711 HUMAN|HGNC=19655|UniProtKB=Q7RTT3 Q7RTT3 SSX9P PTHR14112:SF5 SYNOVIAL SARCOMA, X MEMBER PROTEIN SSX2-RELATED intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HUMAN|HGNC=14964|UniProtKB=Q969N4 Q969N4 TAAR8 PTHR24249:SF405 HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR TRACE AMINE-ASSOCIATED RECEPTOR 8 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021 HUMAN|HGNC=4925|UniProtKB=P52790 P52790 HK3 PTHR19443:SF1 HEXOKINASE HEXOKINASE-3 transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;carbohydrate kinase activity#GO:0019200;hexokinase activity#GO:0004396;phosphotransferase activity, alcohol group as acceptor#GO:0016773 aerobic respiration#GO:0009060;purine ribonucleoside diphosphate catabolic process#GO:0009181;nucleoside diphosphate metabolic process#GO:0009132;pyridine-containing compound metabolic process#GO:0072524;nucleoside phosphate catabolic process#GO:1901292;carbohydrate derivative catabolic process#GO:1901136;nucleoside triphosphate metabolic process#GO:0009141;primary metabolic process#GO:0044238;hexose metabolic process#GO:0019318;purine nucleoside triphosphate metabolic process#GO:0009144;ADP metabolic process#GO:0046031;cellular homeostasis#GO:0019725;purine ribonucleoside diphosphate metabolic process#GO:0009179;generation of precursor metabolites and energy#GO:0006091;organophosphate metabolic process#GO:0019637;glycolytic process#GO:0006096;purine ribonucleoside triphosphate metabolic process#GO:0009205;carbohydrate catabolic process#GO:0016052;nucleotide metabolic process#GO:0009117;ribonucleotide metabolic process#GO:0009259;purine nucleoside diphosphate metabolic process#GO:0009135;pyruvate metabolic process#GO:0006090;monocarboxylic acid metabolic process#GO:0032787;pyridine-containing compound catabolic process#GO:0072526;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;purine nucleoside diphosphate catabolic process#GO:0009137;glucose homeostasis#GO:0042593;nucleobase-containing small molecule metabolic process#GO:0055086;ADP catabolic process#GO:0046032;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;cellular respiration#GO:0045333;ribonucleoside diphosphate catabolic process#GO:0009191;organophosphate catabolic process#GO:0046434;purine nucleotide catabolic process#GO:0006195;glucose 6-phosphate metabolic process#GO:0051156;catabolic process#GO:0009056;nucleoside phosphate metabolic process#GO:0006753;carbohydrate metabolic process#GO:0005975;homeostatic process#GO:0042592;nucleoside diphosphate catabolic process#GO:0009134;purine ribonucleotide catabolic process#GO:0009154;energy derivation by oxidation of organic compounds#GO:0015980;intracellular chemical homeostasis#GO:0055082;nucleotide catabolic process#GO:0009166;nucleobase-containing compound metabolic process#GO:0006139;nucleobase-containing compound catabolic process#GO:0034655;carbohydrate derivative metabolic process#GO:1901135;ribonucleotide catabolic process#GO:0009261;intracellular glucose homeostasis#GO:0001678;oxoacid metabolic process#GO:0043436;small molecule metabolic process#GO:0044281;pyridine nucleotide catabolic process#GO:0019364;phosphorus metabolic process#GO:0006793;carboxylic acid metabolic process#GO:0019752;carbohydrate homeostasis#GO:0033500;ribonucleoside diphosphate metabolic process#GO:0009185;glucose metabolic process#GO:0006006;purine-containing compound catabolic process#GO:0072523;monosaccharide metabolic process#GO:0005996;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;chemical homeostasis#GO:0048878;ATP metabolic process#GO:0046034;nicotinamide nucleotide metabolic process#GO:0046496 mitochondrial outer membrane#GO:0005741;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;cytoplasmic side of membrane#GO:0098562;organelle outer membrane#GO:0031968;cytoplasm#GO:0005737;cytosol#GO:0005829;membrane#GO:0016020;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;side of membrane#GO:0098552;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;outer membrane#GO:0019867;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;mitochondrion#GO:0005739 transferase#PC00220;kinase#PC00137;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=7748|UniProtKB=Q6P3R8 Q6P3R8 NEK5 PTHR44899:SF1 CAMK FAMILY PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE NEK5 transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=3013|UniProtKB=Q14117 Q14117 DPYS PTHR11647:SF50 HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER DIHYDROPYRIMIDINASE dihydropyrimidinase activity#GO:0004157;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides#GO:0016812;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810 small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;nucleobase-containing compound metabolic process#GO:0006139;nucleobase catabolic process#GO:0046113;pyrimidine nucleobase catabolic process#GO:0006208;primary metabolic process#GO:0044238;pyrimidine-containing compound metabolic process#GO:0072527;cellular process#GO:0009987;pyrimidine nucleobase metabolic process#GO:0006206;nucleobase-containing small molecule metabolic process#GO:0055086;nucleobase metabolic process#GO:0009112;metabolic process#GO:0008152 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 hydrolase#PC00121 Axon guidance mediated by semaphorins#P00007>CRMP#P00339;Pyrimidine Metabolism#P02771>Dihydropyrimidinase#P03125 HUMAN|HGNC=4947|UniProtKB=P01903 P01903 HLA-DRA PTHR19944:SF86 MHC CLASS II-RELATED HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN binding#GO:0005488;antigen binding#GO:0003823;peptide binding#GO:0042277;protein-containing complex binding#GO:0044877 regulation of leukocyte cell-cell adhesion#GO:1903037;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;positive regulation of cellular process#GO:0048522;regulation of cell adhesion#GO:0030155;positive regulation of response to stimulus#GO:0048584;positive regulation of cell activation#GO:0050867;biological regulation#GO:0065007;positive regulation of leukocyte cell-cell adhesion#GO:1903039;regulation of immune response#GO:0050776;antigen processing and presentation#GO:0019882;positive regulation of lymphocyte activation#GO:0051251;positive regulation of cell adhesion#GO:0045785;regulation of cell-cell adhesion#GO:0022407;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;positive regulation of leukocyte activation#GO:0002696;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;positive regulation of immune system process#GO:0002684;positive regulation of cell-cell adhesion#GO:0022409;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;regulation of T cell activation#GO:0050863;cellular component assembly#GO:0022607;positive regulation of T cell activation#GO:0050870;regulation of multicellular organismal process#GO:0051239;immune system process#GO:0002376;cellular component organization#GO:0016043;regulation of leukocyte activation#GO:0002694;regulation of cell activation#GO:0050865;positive regulation of multicellular organismal process#GO:0051240;regulation of biological process#GO:0050789;protein-containing complex assembly#GO:0065003;regulation of lymphocyte activation#GO:0051249 lysosome#GO:0005764;plasma membrane protein complex#GO:0098797;vesicle#GO:0031982;lytic vacuole membrane#GO:0098852;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;endosome membrane#GO:0010008;endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;lysosomal membrane#GO:0005765;cell periphery#GO:0071944;membrane#GO:0016020;vesicle membrane#GO:0012506;cytoplasm#GO:0005737;plasma membrane#GO:0005886;vacuole#GO:0005773;protein-containing complex#GO:0032991;late endosome#GO:0005770;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;late endosome membrane#GO:0031902;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;vacuolar membrane#GO:0005774;lytic vacuole#GO:0000323 major histocompatibility complex protein#PC00149 T cell activation#P00053>MHC-antigen#P01316 HUMAN|HGNC=30381|UniProtKB=Q96FV2 Q96FV2 SCRN2 PTHR12994:SF16 SECERNIN SECERNIN-2 HUMAN|HGNC=26508|UniProtKB=Q2TBE0 Q2TBE0 CWF19L2 PTHR12072:SF5 CWF19, CELL CYCLE CONTROL PROTEIN CWF19-LIKE PROTEIN 2 RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;post-mRNA release spliceosomal complex#GO:0071014;spliceosomal complex#GO:0005681 HUMAN|HGNC=18506|UniProtKB=Q96P31 Q96P31 FCRL3 PTHR11481:SF93 IMMUNOGLOBULIN FC RECEPTOR FC RECEPTOR-LIKE PROTEIN 3 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;immune response#GO:0006955;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;immune system process#GO:0002376 cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=25465|UniProtKB=Q5JUQ0 Q5JUQ0 FAM78A PTHR31655:SF3 PROTEIN FAM78A PROTEIN FAM78A HUMAN|HGNC=26777|UniProtKB=Q3SY69 Q3SY69 ALDH1L2 PTHR11699:SF131 ALDEHYDE DEHYDROGENASE-RELATED MITOCHONDRIAL 10-FORMYLTETRAHYDROFOLATE DEHYDROGENASE oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the aldehyde or oxo group of donors#GO:0016903;aldehyde dehydrogenase (NAD+) activity#GO:0004029;oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor#GO:0016620 catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;pteridine-containing compound metabolic process#GO:0042558;folic acid-containing compound metabolic process#GO:0006760;small molecule catabolic process#GO:0044282;carboxylic acid metabolic process#GO:0019752;modified amino acid metabolic process#GO:0006575;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;tetrahydrofolate metabolic process#GO:0046653;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 metabolite interconversion enzyme#PC00262;dehydrogenase#PC00092 5-Hydroxytryptamine degredation#P04372>Aldehyde Dehydrogenase#P04402 HUMAN|HGNC=9178|UniProtKB=P56282 P56282 POLE2 PTHR12708:SF0 DNA POLYMERASE EPSILON SUBUNIT B DNA POLYMERASE EPSILON SUBUNIT 2 cellular response to stress#GO:0033554;nucleic acid biosynthetic process#GO:0141187;DNA synthesis involved in DNA replication#GO:0090592;DNA-templated DNA replication#GO:0006261;cellular response to stimulus#GO:0051716;DNA replication#GO:0006260;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;response to stimulus#GO:0050896;DNA damage tolerance#GO:0006301;DNA damage response#GO:0006974;nucleobase-containing compound biosynthetic process#GO:0034654;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;DNA biosynthetic process#GO:0071897;response to stress#GO:0006950;translesion synthesis#GO:0019985;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058 DNA polymerase complex#GO:0042575;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;epsilon DNA polymerase complex#GO:0008622;membraneless organelle#GO:0043228;intracellular protein-containing complex#GO:0140535;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;chromosome#GO:0005694;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231 DNA-directed DNA polymerase#PC00018 HUMAN|HGNC=32005|UniProtKB=Q5VU36 Q5VU36 SPATA31A5 PTHR21859:SF55 ACROSOME-SPECIFIC PROTEIN SPERMATOGENESIS-ASSOCIATED PROTEIN 31A1-RELATED HUMAN|HGNC=10858|UniProtKB=O43255 O43255 SIAH2 PTHR45877:SF4 E3 UBIQUITIN-PROTEIN LIGASE SIAH2 E3 UBIQUITIN-PROTEIN LIGASE SIAH2 catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein binding#GO:0005515;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;binding#GO:0005488;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;enzyme binding#GO:0019899 macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 ubiquitin-protein ligase#PC00234 Wnt signaling pathway#P00057>SIAH-1#P01433 HUMAN|HGNC=23022|UniProtKB=Q86YH2 Q86YH2 ZNF280B PTHR24388:SF110 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 280B transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=7639|UniProtKB=Q99457 Q99457 NAP1L3 PTHR11875:SF38 TESTIS-SPECIFIC Y-ENCODED PROTEIN NUCLEOSOME ASSEMBLY PROTEIN 1-LIKE 3 histone binding#GO:0042393;chromatin binding#GO:0003682;binding#GO:0005488;protein binding#GO:0005515 cellular component assembly#GO:0022607;chromatin remodeling#GO:0006338;chromatin organization#GO:0006325;protein-DNA complex assembly#GO:0065004;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;protein-DNA complex organization#GO:0071824;nucleosome organization#GO:0034728;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933 membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;chromatin#GO:0000785;nucleus#GO:0005634 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=34388|UniProtKB=A8MYP8 A8MYP8 CIMAP1B PTHR21580:SF19 SHIPPO-1-RELATED CILIARY MICROTUBULE ASSOCIATED PROTEIN 1B reproductive process#GO:0022414;microtubule-based movement#GO:0007018;cell motility#GO:0048870;sperm motility#GO:0097722;cellular process#GO:0009987;cilium movement involved in cell motility#GO:0060294;microtubule-based process#GO:0007017;cilium-dependent cell motility#GO:0060285;cilium or flagellum-dependent cell motility#GO:0001539;cilium movement#GO:0003341;flagellated sperm motility#GO:0030317 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cilium#GO:0005929;9+2 motile cilium#GO:0097729;cytoskeleton#GO:0005856;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;motile cilium#GO:0031514;cellular anatomical structure#GO:0110165;sperm flagellum#GO:0036126 structural protein#PC00211 HUMAN|HGNC=1983|UniProtKB=Q969X6 Q969X6 UTP4 PTHR44163:SF1 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG RNA metabolic process#GO:0016070;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;ribonucleoprotein complex biogenesis#GO:0022613;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;ribosomal small subunit biogenesis#GO:0042274;gene expression#GO:0010467;RNA processing#GO:0006396;maturation of SSU-rRNA#GO:0030490;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;rRNA processing#GO:0006364;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;rRNA metabolic process#GO:0016072;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;macromolecule biosynthetic process#GO:0009059 membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;t-UTP complex#GO:0034455;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;preribosome#GO:0030684;ribonucleoprotein complex#GO:1990904;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;small-subunit processome#GO:0032040 HUMAN|HGNC=21163|UniProtKB=Q14676 Q14676 MDC1 PTHR23196:SF34 PAX TRANSCRIPTION ACTIVATION DOMAIN INTERACTING PROTEIN MEDIATOR OF DNA DAMAGE CHECKPOINT PROTEIN 1 regulation of DNA-templated transcription#GO:0006355;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;cellular response to stress#GO:0033554;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of RNA metabolic process#GO:0051254;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of DNA-templated transcription initiation#GO:2000142;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of transcription by RNA polymerase II#GO:0045944;DNA damage response#GO:0006974;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of macromolecule biosynthetic process#GO:0010556;response to stress#GO:0006950;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;methyltransferase complex#GO:0034708;organelle#GO:0043226;organelle lumen#GO:0043233;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;nuclear protein-containing complex#GO:0140513;histone methyltransferase complex#GO:0035097;transferase complex#GO:1990234 HUMAN|HGNC=6476|UniProtKB=P18627 P18627 LAG3 PTHR11890:SF18 INTERLEUKIN-1 RECEPTOR FAMILY MEMBER LYMPHOCYTE ACTIVATION GENE 3 PROTEIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=11716|UniProtKB=Q99594 Q99594 TEAD3 PTHR11834:SF7 TRANSCRIPTIONAL ENHANCER FACTOR TEF RELATED TRANSCRIPTIONAL ENHANCER FACTOR TEF-5 double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;animal organ development#GO:0048513;multicellular organism development#GO:0007275;developmental process#GO:0032502;hippo signaling#GO:0035329;embryo development#GO:0009790;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;intracellular signal transduction#GO:0035556;regulation of RNA metabolic process#GO:0051252;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;cell communication#GO:0007154;embryonic organ development#GO:0048568;animal gross anatomical part developmental process#GO:0160108;signaling#GO:0023052;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667 winged helix/forkhead transcription factor#PC00246;gene-specific transcriptional regulator#PC00264;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=18232|UniProtKB=Q5W0U4 Q5W0U4 BSPRY PTHR24103:SF568 E3 UBIQUITIN-PROTEIN LIGASE TRIM B BOX AND SPRY DOMAIN-CONTAINING PROTEIN acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 response to stress#GO:0006950;response to biotic stimulus#GO:0009607;defense response to symbiont#GO:0140546;immune response#GO:0006955;defense response to other organism#GO:0098542;response to stimulus#GO:0050896;response to other organism#GO:0051707;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;immune system process#GO:0002376;innate immune response#GO:0045087;defense response#GO:0006952;response to external stimulus#GO:0009605 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=6493|UniProtKB=Q13753 Q13753 LAMC2 PTHR10574:SF313 NETRIN/LAMININ-RELATED LAMININ SUBUNIT GAMMA-2 cell development#GO:0048468;cell morphogenesis#GO:0000902;cell differentiation#GO:0030154;cell projection organization#GO:0030030;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;axonogenesis#GO:0007409;neuron development#GO:0048666;system development#GO:0048731;anatomical structure development#GO:0048856;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;plasma membrane bounded cell projection organization#GO:0120036;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;tissue development#GO:0009888;cellular process#GO:0009987;axon guidance#GO:0007411;axon development#GO:0061564;neuron projection development#GO:0031175;neurogenesis#GO:0022008;cell projection morphogenesis#GO:0048858;neuron projection guidance#GO:0097485;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;neuron projection morphogenesis#GO:0048812;plasma membrane bounded cell projection morphogenesis#GO:0120039;developmental process#GO:0032502;neuron differentiation#GO:0030182 cellular anatomical structure#GO:0110165;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;basement membrane#GO:0005604;extracellular region#GO:0005576 extracellular matrix protein#PC00102 Integrin signalling pathway#P00034>Laminin#P00947 HUMAN|HGNC=18101|UniProtKB=Q5J5C9 Q5J5C9 DEFB121 PTHR15001:SF8 BETA-DEFENSIN 123-RELATED BETA-DEFENSIN 121 cell killing#GO:0001906;immune system process#GO:0002376;defense response#GO:0006952;response to external stimulus#GO:0009605;innate immune response#GO:0045087;cellular process#GO:0009987;defense response to symbiont#GO:0140546;immune response#GO:0006955;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;response to other organism#GO:0051707;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;defense response to other organism#GO:0098542;response to stimulus#GO:0050896 defense/immunity protein#PC00090;antimicrobial response protein#PC00051 HUMAN|HGNC=30898|UniProtKB=Q5T686 Q5T686 AVPI1 PTHR14350:SF2 ARGININE VASOPRESSIN-INDUCED PROTEIN 1 ARGININE VASOPRESSIN-INDUCED PROTEIN 1 regulation of MAPK cascade#GO:0043408;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;positive regulation of MAPK cascade#GO:0043410;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of response to stimulus#GO:0048584;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;positive regulation of signaling#GO:0023056;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794 HUMAN|HGNC=2460|UniProtKB=P67870 P67870 CSNK2B PTHR11740:SF45 CASEIN KINASE II SUBUNIT BETA CASEIN KINASE II SUBUNIT BETA protein kinase regulator activity#GO:0019887;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;enzyme regulator activity#GO:0030234 transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;protein kinase complex#GO:1902911;serine/threonine protein kinase complex#GO:1902554;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737 protein-binding activity modulator#PC00095;kinase modulator#PC00140 Cadherin signaling pathway#P00012>Casein kinase II#P00462;Wnt signaling pathway#P00057>Casein Kinase 2#P01459;Parkinson disease#P00049>Casein kinase II#P01236 HUMAN|HGNC=16509|UniProtKB=Q9Y2D8 Q9Y2D8 SSX2IP PTHR46507:SF1 AFADIN- AND ALPHA-ACTININ-BINDING PROTEIN AFADIN- AND ALPHA-ACTININ-BINDING PROTEIN cellular component organization#GO:0016043;cilium assembly#GO:0060271;microtubule-based movement#GO:0007018;cell projection organization#GO:0030030;intraciliary transport#GO:0042073;organelle assembly#GO:0070925;microtubule-based transport#GO:0099111;cellular localization#GO:0051641;localization#GO:0051179;cilium organization#GO:0044782;intraciliary transport involved in cilium assembly#GO:0035735;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cell projection assembly#GO:0030031;establishment of localization in cell#GO:0051649;cytoskeleton-dependent intracellular transport#GO:0030705;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;intracellular transport#GO:0046907;plasma membrane bounded cell projection assembly#GO:0120031;transport#GO:0006810;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017 microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;microtubule organizing center#GO:0005815;centrosome#GO:0005813;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;cell projection#GO:0042995;centriolar satellite#GO:0034451;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;cilium#GO:0005929;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=23508|UniProtKB=Q6ZVD7 Q6ZVD7 STOX1 PTHR22437:SF1 WINGED HELIX DOMAIN-CONTAINING PROTEIN STORKHEAD-BOX PROTEIN 1 double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 HUMAN|HGNC=14879|UniProtKB=Q9UL03 Q9UL03 INTS6 PTHR12957:SF23 DEAD/H BOX POLYPEPTIDE 26/DICE1-RELATED INTEGRATOR COMPLEX SUBUNIT 6 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 nucleic acid biosynthetic process#GO:0141187;snRNA metabolic process#GO:0016073;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;snRNA 3'-end processing#GO:0034472;RNA biosynthetic process#GO:0032774;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;snRNA processing#GO:0016180;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;gene expression#GO:0010467 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;integrator complex#GO:0032039;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 RNA helicase#PC00032 HUMAN|HGNC=12456|UniProtKB=Q15695 Q15695 ZRSR2P1 PTHR12620:SF33 U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT U2 SMALL NUCLEAR RIBONUCLEOPROTEIN AUXILIARY FACTOR 35 KDA SUBUNIT-RELATED PROTEIN 1 binding#GO:0005488;pre-mRNA binding#GO:0036002;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139 nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;spliceosomal complex#GO:0005681;nucleus#GO:0005634 RNA splicing factor#PC00148 mRNA splicing#P00058>U2AF65#P01475 HUMAN|HGNC=20660|UniProtKB=Q96SJ8 Q96SJ8 TSPAN18 PTHR19282:SF249 TETRASPANIN TETRASPANIN-18 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=29682|UniProtKB=Q969S9 Q969S9 GFM2 PTHR43261:SF9 TRANSLATION ELONGATION FACTOR G-RELATED RIBOSOME-RELEASING FACTOR 2, MITOCHONDRIAL hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787 metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;organelle organization#GO:0006996;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;biosynthetic process#GO:0009058;translation#GO:0006412;protein metabolic process#GO:0019538;cellular component disassembly#GO:0022411;organelle disassembly#GO:1903008;mitochondrial gene expression#GO:0140053;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;mitochondrial translation#GO:0032543;protein biosynthetic process#GO:0160307 translation factor#PC00223;translational protein#PC00263;translation elongation factor#PC00222 HUMAN|HGNC=24125|UniProtKB=A2A2Y4 A2A2Y4 FRMD3 PTHR23280:SF8 4.1 G PROTEIN FERM DOMAIN-CONTAINING PROTEIN 3 cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165;actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=23581|UniProtKB=Q5SRD1 Q5SRD1 TIMM23B PTHR15371:SF34 TIM23 MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM23B transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;transmembrane protein transporter activity#GO:0008320 mitochondrial transmembrane transport#GO:1990542;protein transport#GO:0015031;localization#GO:0051179;cellular localization#GO:0051641;transmembrane transport#GO:0055085;protein localization to mitochondrion#GO:0070585;mitochondrial transport#GO:0006839;protein localization to organelle#GO:0033365;protein transmembrane import into intracellular organelle#GO:0044743;intracellular protein transport#GO:0006886;protein transmembrane transport#GO:0071806;transport#GO:0006810;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;establishment of protein localization to organelle#GO:0072594;intracellular protein transmembrane transport#GO:0065002;establishment of localization#GO:0051234;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule localization#GO:0033036;mitochondrial protein import pathway#GO:7770058;protein import into mitochondrial matrix#GO:0030150 inner mitochondrial membrane protein complex#GO:0098800;organelle membrane#GO:0031090;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;TIM23 mitochondrial import inner membrane translocase complex#GO:0005744;mitochondrial membrane#GO:0031966;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;organelle envelope#GO:0031967;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 transporter#PC00227;amino acid transporter#PC00046;secondary carrier transporter#PC00258 HUMAN|HGNC=14068|UniProtKB=Q9UQL6 Q9UQL6 HDAC5 PTHR10625:SF28 HISTONE DEACETYLASE HDAC1-RELATED HISTONE DEACETYLASE 5 histone modifying activity#GO:0140993;catalytic activity, acting on a protein#GO:0140096;deacetylase activity#GO:0019213;deacylase activity#GO:0160215;histone deacetylase activity#GO:0004407;catalytic activity#GO:0003824 chromatin remodeling#GO:0006338;chromatin organization#GO:0006325;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;cellular process#GO:0009987;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;cellular component organization#GO:0016043;epigenetic regulation of gene expression#GO:0040029;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840 nucleus#GO:0005634;histone deacetylase complex#GO:0000118;membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;nuclear protein-containing complex#GO:0140513;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=35165|UniProtKB=P0DMQ5 P0DMQ5 INAFM2 PTHR34929:SF4 ZGC:153157 TRANSMEMBRANE PROTEIN INAFM2-RELATED HUMAN|HGNC=20596|UniProtKB=Q8NEM7 Q8NEM7 SUPT20H PTHR13526:SF18 TRANSCRIPTION FACTOR SPT20 HOMOLOG TRANSCRIPTION FACTOR SPT20 HOMOLOG transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 intracellular membraneless organelle#GO:0043232;peptidase complex#GO:1905368;protein-containing complex#GO:0032991;chromatin#GO:0000785;SAGA complex#GO:0000124;histone acetyltransferase complex#GO:0000123;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;transferase complex#GO:1990234;organelle#GO:0043226;cellular anatomical structure#GO:0110165;chromosome#GO:0005694;acetyltransferase complex#GO:1902493;intracellular anatomical structure#GO:0005622;SAGA-type complex#GO:0070461;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;protein acetyltransferase complex#GO:0031248 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=8846|UniProtKB=O15055 O15055 PER2 PTHR11269:SF9 PERIOD CIRCADIAN PROTEIN PERIOD CIRCADIAN PROTEIN HOMOLOG 2 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription factor binding#GO:0008134;double-stranded DNA binding#GO:0003690;protein binding#GO:0005515;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676 negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;circadian rhythm#GO:0007623;negative regulation of DNA-templated transcription#GO:0045892;rhythmic process#GO:0048511;negative regulation of metabolic process#GO:0009892;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;circadian regulation of gene expression#GO:0032922;response to abiotic stimulus#GO:0009628;response to external stimulus#GO:0009605;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;photoperiodism#GO:0009648;negative regulation of cellular process#GO:0048523;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of circadian rhythm#GO:0042752;negative regulation of macromolecule metabolic process#GO:0010605;response to radiation#GO:0009314;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of macromolecule metabolic process#GO:0060255;response to light stimulus#GO:0009416;regulation of cellular process#GO:0050794 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 transcription cofactor#PC00217 Circadian clock system#P00015>per#G01503;Circadian clock system#P00015>per#G01499;Circadian clock system#P00015>Per#P00504 HUMAN|HGNC=17223|UniProtKB=Q9Y2C2 Q9Y2C2 UST PTHR12129:SF15 HEPARAN SULFATE 2-O-SULFOTRANSFERASE URONYL 2-SULFOTRANSFERASE metabolite interconversion enzyme#PC00262;transferase#PC00220 HUMAN|HGNC=26331|UniProtKB=Q96DL1 Q96DL1 NXPE2 PTHR16165:SF10 NXPE FAMILY MEMBER NXPE FAMILY MEMBER 2 HUMAN|HGNC=21066|UniProtKB=Q9P0N9 Q9P0N9 TBC1D7 PTHR13530:SF3 TBC1 DOMAIN FAMILY MEMBER 7 TBC1 DOMAIN FAMILY MEMBER 7 molecular function regulator activity#GO:0098772;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;protein-containing complex binding#GO:0044877;enzyme regulator activity#GO:0030234;binding#GO:0005488 regulation of TOR signaling#GO:0032006;negative regulation of response to stimulus#GO:0048585;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;negative regulation of TOR signaling#GO:0032007;regulation of cell communication#GO:0010646;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 GTPase-activating protein#PC00257 HUMAN|HGNC=24248|UniProtKB=Q8N6R0 Q8N6R0 METTL13 PTHR12176:SF78 SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN EEF1A LYSINE AND N-TERMINAL METHYLTRANSFERASE protein methyltransferase activity#GO:0008276;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;N-methyltransferase activity#GO:0008170;protein-lysine N-methyltransferase activity#GO:0016279;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;lysine N-methyltransferase activity#GO:0016278 methyltransferase#PC00155;transferase#PC00220;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=28084|UniProtKB=Q2M1V0 Q2M1V0 ISX PTHR24329:SF362 HOMEOBOX PROTEIN ARISTALESS INTESTINE-SPECIFIC HOMEOBOX DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biological process#GO:0050789;cell development#GO:0048468;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;neuron development#GO:0048666;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;cellular process#GO:0009987;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;nervous system development#GO:0007399;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;developmental process#GO:0032502;neuron differentiation#GO:0030182;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;multicellular organism development#GO:0007275 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 gene-specific transcriptional regulator#PC00264;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=13633|UniProtKB=Q15848 Q15848 ADIPOQ PTHR15427:SF20 EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER ADIPONECTIN signaling receptor activator activity#GO:0030546;hormone activity#GO:0005179;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018 negative regulation of cell communication#GO:0010648;negative regulation of cellular process#GO:0048523;negative regulation of signaling#GO:0023057;regulation of cell differentiation#GO:0045595;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;negative regulation of response to stimulus#GO:0048585;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;negative regulation of signal transduction#GO:0009968;biological regulation#GO:0065007;regulation of developmental process#GO:0050793;regulation of signal transduction#GO:0009966;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 scaffold/adaptor protein#PC00226 Gonadotropin-releasing hormone receptor pathway#P06664>Adiponectin#P06761 HUMAN|HGNC=30540|UniProtKB=Q96G28 Q96G28 CFAP36 PTHR21532:SF0 PHOSPHODIESTERASE HL CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 36 ciliary base#GO:0097546;intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;organelle#GO:0043226;ciliary plasm#GO:0097014;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;cilium#GO:0005929;cytoskeleton#GO:0005856;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;axoneme#GO:0005930;membraneless organelle#GO:0043228 phosphodiesterase#PC00185;metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HUMAN|HGNC=18413|UniProtKB=Q8IUH4 Q8IUH4 ZDHHC13 PTHR24161:SF16 ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED PALMITOYLTRANSFERASE ZDHHC13 palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139 protein modifying enzyme#PC00260 HUMAN|HGNC=23836|UniProtKB=O15062 O15062 ZBTB5 PTHR24394:SF17 ZINC FINGER PROTEIN ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 5 DNA-binding transcription repressor activity#GO:0001217;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=30519|UniProtKB=Q969I3 Q969I3 GLYATL1 PTHR15298:SF7 L-COA N-ACYLTRANSFERASE-RELATED GLYCINE N-ACYLTRANSFERASE-LIKE PROTEIN 1 acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740 primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;cellular process#GO:0009987;proteinogenic amino acid metabolic process#GO:0170039;small molecule metabolic process#GO:0044281;amino acid metabolic process#GO:0006520;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739 acyltransferase#PC00042 HUMAN|HGNC=12385|UniProtKB=Q53GA4 Q53GA4 PHLDA2 PTHR15478:SF15 PLECKSTRIN HOMOLOGY-LIKE DOMAIN, PQ-RICH PROTEIN PLECKSTRIN HOMOLOGY-LIKE DOMAIN FAMILY A MEMBER 2 developmental process#GO:0032502;animal gross anatomical part developmental process#GO:0160108;placenta development#GO:0001890;animal organ development#GO:0048513;anatomical structure development#GO:0048856 HUMAN|HGNC=33914|UniProtKB=P59773 P59773 MINAR2 PTHR31530:SF4 MAJOR INTRINSICALLY DISORDERED NOTCH2-BINDING RECEPTOR 1 MINAR1 FAMILY MEMBER MAJOR INTRINSICALLY DISORDERED NOTCH2-BINDING RECEPTOR 1-LIKE transmembrane signal receptor#PC00197 HUMAN|HGNC=13398|UniProtKB=Q15738 Q15738 NSDHL PTHR10366:SF860 NAD DEPENDENT EPIMERASE/DEHYDRATASE STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824 small molecule metabolic process#GO:0044281;secondary alcohol metabolic process#GO:1902652;steroid metabolic process#GO:0008202;primary metabolic process#GO:0044238;cellular process#GO:0009987;sterol metabolic process#GO:0016125;metabolic process#GO:0008152;alcohol metabolic process#GO:0006066;cholesterol metabolic process#GO:0008203;lipid metabolic process#GO:0006629 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 lyase#PC00144;dehydratase#PC00091;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=1008|UniProtKB=O00512 O00512 BCL9 PTHR15185:SF5 BCL9 B-CELL CLL_LYMPHOMA 9 PROTEIN binding#GO:0005488;protein binding#GO:0005515;beta-catenin binding#GO:0008013 cell surface receptor signaling pathway#GO:0007166;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;signaling#GO:0023052;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;canonical Wnt signaling pathway#GO:0060070;cell communication#GO:0007154;positive regulation of biosynthetic process#GO:0009891;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;Wnt signaling pathway#GO:0016055;cellular response to stimulus#GO:0051716 nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634 Wnt signaling pathway#P00057>Bcl9#P01450 HUMAN|HGNC=14060|UniProtKB=Q9UBZ9 Q9UBZ9 REV1 PTHR45990:SF1 DNA REPAIR PROTEIN REV1 TRANSLESION SYNTHESIS PROTEIN REV1 DNA-directed DNA polymerase activity#GO:0003887;transferase activity, transferring phosphorus-containing groups#GO:0016772;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on DNA#GO:0140097;DNA polymerase activity#GO:0034061 translesion synthesis#GO:0019985;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;DNA biosynthetic process#GO:0071897;response to stress#GO:0006950;macromolecule metabolic process#GO:0043170;DNA damage tolerance#GO:0006301;DNA damage response#GO:0006974;DNA metabolic process#GO:0006259;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;DNA replication#GO:0006260;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;DNA synthesis involved in DNA replication#GO:0090592;nucleic acid biosynthetic process#GO:0141187;cellular response to stress#GO:0033554 intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;site of DNA damage#GO:0090734;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;site of double-strand break#GO:0035861;chromosome#GO:0005694;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231 DNA metabolism protein#PC00009 HUMAN|HGNC=28677|UniProtKB=Q53SZ7 Q53SZ7 PRR30 PTHR22235:SF2 PROLINE-RICH PROTEIN 30 PROLINE-RICH PROTEIN 30 HUMAN|HGNC=9354|UniProtKB=P30048 P30048 PRDX3 PTHR10681:SF182 THIOREDOXIN PEROXIDASE THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE, MITOCHONDRIAL peroxidase activity#GO:0004601;antioxidant activity#GO:0016209;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on peroxide as acceptor#GO:0016684 response to stress#GO:0006950;cellular process#GO:0009987;catabolic process#GO:0009056;response to stimulus#GO:0050896;hydrogen peroxide metabolic process#GO:0042743;homeostatic process#GO:0042592;reactive oxygen species metabolic process#GO:0072593;metabolic process#GO:0008152;response to oxidative stress#GO:0006979;cellular homeostasis#GO:0019725;cell redox homeostasis#GO:0045454 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cytosol#GO:0005829;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 oxidoreductase#PC00176;peroxidase#PC00180 HUMAN|HGNC=25007|UniProtKB=Q8N3Z3 Q8N3Z3 GTPBP8 PTHR46498:SF1 GTP-BINDING PROTEIN 8 GTP-BINDING PROTEIN 8 mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=19000|UniProtKB=Q6AZY7 Q6AZY7 SCARA3 PTHR24637:SF421 COLLAGEN SCAVENGER RECEPTOR CLASS A MEMBER 3 HUMAN|HGNC=33731|UniProtKB=A6NLC5 A6NLC5 C3orf70 PTHR31785:SF2 UPF0524 PROTEIN C3ORF70 UPF0524 PROTEIN C3ORF70 animal gross anatomical part developmental process#GO:0160108;rhythmic process#GO:0048511;developmental process#GO:0032502;multicellular organism development#GO:0007275;anatomical structure development#GO:0048856;system development#GO:0048731;circadian rhythm#GO:0007623;multicellular organismal process#GO:0032501;nervous system development#GO:0007399 HUMAN|HGNC=10878|UniProtKB=Q9Y336 Q9Y336 SIGLEC9 PTHR12035:SF138 SIALIC ACID BINDING IMMUNOGLOBULIN-LIKE LECTIN SIALIC ACID-BINDING IG-LIKE LECTIN 9 organic acid binding#GO:0043177;carbohydrate derivative binding#GO:0097367;ion binding#GO:0043167;binding#GO:0005488;carboxylic acid binding#GO:0031406;anion binding#GO:0043168;small molecule binding#GO:0036094 cellular process#GO:0009987;cell adhesion#GO:0007155 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 immunoglobulin superfamily cell adhesion molecule#PC00125;cell adhesion molecule#PC00069 HUMAN|HGNC=26402|UniProtKB=Q52LD8 Q52LD8 RFTN2 PTHR17601:SF1 RAFTLIN-RELATED RAFTLIN-2 HUMAN|HGNC=11568|UniProtKB=Q13395 Q13395 TARBP1 PTHR12029:SF11 RNA METHYLTRANSFERASE TRNA (GUANOSINE(18)-2'-O)-METHYLTRANSFERASE TARBP1 RNA methyltransferase activity#GO:0008173;catalytic activity, acting on RNA#GO:0140098;tRNA methyltransferase activity#GO:0008175;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a tRNA#GO:0140101;tRNA (guanine) methyltransferase activity#GO:0016423;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757 macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;methylation#GO:0032259;RNA methylation#GO:0001510;RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187;macromolecule methylation#GO:0043414;tRNA modification#GO:0006400;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467;tRNA methylation#GO:0030488;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 RNA methyltransferase#PC00033;RNA metabolism protein#PC00031 HUMAN|HGNC=9787|UniProtKB=O95235 O95235 KIF20A PTHR24115:SF352 KINESIN-RELATED KINESIN-LIKE PROTEIN KIF20A microtubule binding#GO:0008017;polypeptide conformation or assembly isomerase activity#GO:0120544;hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887;microtubule motor activity#GO:0003777;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543;tubulin binding#GO:0015631;ribonucleoside triphosphate phosphatase activity#GO:0017111;isomerase activity#GO:0016853;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;ATP-dependent activity#GO:0140657;protein binding#GO:0005515;hydrolase activity, acting on acid anhydrides#GO:0016817;cytoskeletal protein binding#GO:0008092;cytoskeletal motor activity#GO:0003774 microtubule-based process#GO:0007017;microtubule-based movement#GO:0007018;cellular process#GO:0009987 nucleus#GO:0005634;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;supramolecular polymer#GO:0099081;cytoskeleton#GO:0005856;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=4750|UniProtKB=Q99879 Q99879 H2BC14 PTHR23428:SF232 HISTONE H2B HISTONE H2B TYPE 1-M defense response to other organism#GO:0098542;response to other organism#GO:0051707;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;immune response#GO:0006955;defense response to symbiont#GO:0140546;antibacterial humoral response#GO:0019731;innate immune response#GO:0045087;defense response#GO:0006952;response to external stimulus#GO:0009605;antimicrobial humoral response#GO:0019730;humoral immune response#GO:0006959;response to stimulus#GO:0050896;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;immune system process#GO:0002376;response to bacterium#GO:0009617;defense response to bacterium#GO:0042742 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=8977|UniProtKB=O00329 O00329 PIK3CD PTHR10048:SF35 PHOSPHATIDYLINOSITOL KINASE PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphatidylinositol kinase activity#GO:0052742;transferase activity#GO:0016740;catalytic activity#GO:0003824;lipid kinase activity#GO:0001727;phosphotransferase activity, alcohol group as acceptor#GO:0016773 lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474;metabolic process#GO:0008152;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;cell migration#GO:0016477;glycerophospholipid metabolic process#GO:0006650;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0043491;signal transduction#GO:0007165;organophosphate metabolic process#GO:0019637;intracellular signal transduction#GO:0035556;organophosphate biosynthetic process#GO:0090407;cell communication#GO:0007154;phosphatidylinositol phosphate biosynthetic process#GO:0046854;signaling#GO:0023052;phospholipid metabolic process#GO:0006644;cell motility#GO:0048870;phospholipid biosynthetic process#GO:0008654;regulation of cellular process#GO:0050794;glycerolipid metabolic process#GO:0046486;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793 transferase complex#GO:1990234;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;extrinsic component of membrane#GO:0019898;cell periphery#GO:0071944;membrane#GO:0016020;membrane protein complex#GO:0098796;cytoplasm#GO:0005737;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 kinase#PC00137 Integrin signalling pathway#P00034>PI3K#P00936;Axon guidance mediated by netrin#P00009>PI3K#P00363;p53 pathway feedback loops 2#P04398>PI3K#P04661;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>PI3K#P00900;Hypoxia response via HIF activation#P00030>PI3K#P00823;PDGF signaling pathway#P00047>PI3K#P01168;Ras Pathway#P04393>PI3K#P04567;Apoptosis signaling pathway#P00006>PI3K#P00310;Endothelin signaling pathway#P00019>PI3K#P00577;p53 pathway#P00059>PI3K#P04609;VEGF signaling pathway#P00056>PI3K#P01413;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PI3K#P00868;T cell activation#P00053>PI3K#P01322;FGF signaling pathway#P00021>PI3K#P00640;B cell activation#P00010>PI3K#P00391;EGF receptor signaling pathway#P00018>PI3K#P00557;Angiogenesis#P00005>PI3K#P00236 HUMAN|HGNC=33155|UniProtKB=Q2VPJ9 Q2VPJ9 LRRC75B PTHR39654:SF5 LEUCINE-RICH REPEAT-CONTAINING PROTEIN 75A-LIKE ISOFORM X1 LEUCINE-RICH REPEAT-CONTAINING PROTEIN 75B HUMAN|HGNC=28916|UniProtKB=Q8N9B5 Q8N9B5 JMY PTHR23330:SF8 P300 TRANSCRIPTIONAL COFACTOR JMY-RELATED JUNCTION-MEDIATING AND -REGULATORY PROTEIN transcription coactivator activity#GO:0003713;protein-containing complex binding#GO:0044877;transcription coregulator activity#GO:0003712;binding#GO:0005488;transcription regulator activity#GO:0140110 regulation of apoptotic process#GO:0042981;cellular component organization or biogenesis#GO:0071840;positive regulation of apoptotic process#GO:0043065;organelle organization#GO:0006996;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cytoskeleton organization#GO:0007010;signal transduction by p53 class mediator#GO:0072331;intrinsic apoptotic signaling pathway#GO:0097193;cellular component organization#GO:0016043;regulation of programmed cell death#GO:0043067;apoptotic process#GO:0006915;regulation of biological process#GO:0050789;positive regulation of programmed cell death#GO:0043068;response to stimulus#GO:0050896;intrinsic apoptotic signaling pathway by p53 class mediator#GO:0072332;signaling#GO:0023052;apoptotic signaling pathway#GO:0097190;actin filament organization#GO:0007015;Arp2/3 complex-mediated actin nucleation#GO:0034314;positive regulation of cellular process#GO:0048522;biological regulation#GO:0065007;actin filament-based process#GO:0030029;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;supramolecular fiber organization#GO:0097435;programmed cell death#GO:0012501;cell death#GO:0008219;cellular response to stimulus#GO:0051716;actin cytoskeleton organization#GO:0030036;actin nucleation#GO:0045010;regulation of cellular process#GO:0050794 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 HUMAN|Gene=YJ012_HUMAN|UniProtKB=Q8N9G6 Q8N9G6 PTHR15566:SF10 POM121-LIKE UPF0607 PROTEIN ENSP00000332738-RELATED HUMAN|HGNC=21734|UniProtKB=Q969G2 Q969G2 LHX4 PTHR24208:SF116 LIM/HOMEOBOX PROTEIN LHX LIM_HOMEOBOX PROTEIN LHX4 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690 neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;multicellular organism development#GO:0007275;developmental process#GO:0032502;neuron differentiation#GO:0030182;nervous system development#GO:0007399;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 HUMAN|HGNC=12269|UniProtKB=Q9NSU2 Q9NSU2 TREX1 PTHR13058:SF27 THREE PRIME REPAIR EXONUCLEASE 1, 2 THREE-PRIME REPAIR EXONUCLEASE 1 3'-5' exonuclease activity#GO:0008408;catalytic activity, acting on DNA#GO:0140097;DNA exonuclease activity#GO:0004529;hydrolase activity, acting on ester bonds#GO:0016788;DNA nuclease activity#GO:0004536;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;nuclease activity#GO:0004518;DNA exonuclease activity, producing 5'-phosphomonoesters#GO:0016895;3'-5'-DNA exonuclease activity#GO:0008296;hydrolase activity#GO:0016787;exonuclease activity#GO:0004527 nucleobase-containing compound metabolic process#GO:0006139;catabolic process#GO:0009056;nucleic acid catabolic process#GO:0141188;cellular process#GO:0009987;nucleobase-containing compound catabolic process#GO:0034655;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;DNA catabolic process#GO:0006308;DNA metabolic process#GO:0006259;macromolecule catabolic process#GO:0009057 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=30613|UniProtKB=Q5MJ70 Q5MJ70 SPDYA PTHR31545:SF4 SEEDY PROTEIN A/C FAMILY MEMBER SPEEDY PROTEIN A enzyme binding#GO:0019899;protein kinase binding#GO:0019901;binding#GO:0005488;kinase binding#GO:0019900;protein binding#GO:0005515 cellular process#GO:0009987;positive regulation of biological process#GO:0048518;cell cycle G1/S phase transition#GO:0044843;positive regulation of cellular process#GO:0048522;biological regulation#GO:0065007;G1/S transition of mitotic cell cycle#GO:0000082;mitotic cell cycle process#GO:1903047;cell cycle#GO:0007049;positive regulation of cell population proliferation#GO:0008284;cell cycle process#GO:0022402;regulation of biological process#GO:0050789;cell cycle phase transition#GO:0044770;regulation of cellular process#GO:0050794;mitotic cell cycle#GO:0000278;mitotic cell cycle phase transition#GO:0044772;regulation of cell population proliferation#GO:0042127 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=20344|UniProtKB=Q8N806 Q8N806 UBR7 PTHR13513:SF9 E3 UBIQUITIN-PROTEIN LIGASE UBR7 E3 UBIQUITIN-PROTEIN LIGASE UBR7-RELATED ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=4439|UniProtKB=P07359 P07359 GP1BA PTHR24373:SF371 SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN PLATELET GLYCOPROTEIN IB ALPHA CHAIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;blood coagulation#GO:0007596;response to stress#GO:0006950;response to wounding#GO:0009611;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;coagulation#GO:0050817;protein maturation#GO:0051604;multicellular organismal process#GO:0032501;gene expression#GO:0010467;biological regulation#GO:0065007;biosynthetic process#GO:0009058;blood coagulation, fibrin clot formation#GO:0072378;protein metabolic process#GO:0019538;protein activation cascade#GO:0072376;regulation of biological quality#GO:0065008;wound healing#GO:0042060;hemostasis#GO:0007599;primary metabolic process#GO:0044238;regulation of body fluid levels#GO:0050878;response to stimulus#GO:0050896 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 Blood coagulation#P00011>GP Ibalpha#P00449 HUMAN|HGNC=13156|UniProtKB=P51508 P51508 ZNF81 PTHR24377:SF5 IP01015P-RELATED ZINC FINGER PROTEIN 81 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=24300|UniProtKB=Q96N19 Q96N19 GPR137 PTHR15146:SF5 INTEGRAL MEMBRANE PROTEIN GPR137 INTEGRAL MEMBRANE PROTEIN GPR137 positive regulation of response to stimulus#GO:0048584;negative regulation of immune system process#GO:0002683;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of bone remodeling#GO:0046850;positive regulation of TORC1 signaling#GO:1904263;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;regulation of cell development#GO:0060284;regulation of TORC1 signaling#GO:1903432;regulation of catabolic process#GO:0009894;negative regulation of cellular process#GO:0048523;positive regulation of intracellular signal transduction#GO:1902533;regulation of cell differentiation#GO:0045595;regulation of response to stimulus#GO:0048583;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of developmental process#GO:0050793;regulation of cell communication#GO:0010646;negative regulation of multicellular organismal process#GO:0051241;positive regulation of signal transduction#GO:0009967;regulation of hemopoiesis#GO:1903706;positive regulation of TOR signaling#GO:0032008;regulation of tissue remodeling#GO:0034103;regulation of multicellular organismal process#GO:0051239;positive regulation of biological process#GO:0048518;regulation of TOR signaling#GO:0032006;negative regulation of biological process#GO:0048519;regulation of autophagy#GO:0010506;regulation of biological process#GO:0050789;regulation of multicellular organismal development#GO:2000026;positive regulation of signaling#GO:0023056;regulation of myeloid cell differentiation#GO:0045637;regulation of intracellular signal transduction#GO:1902531;regulation of bone resorption#GO:0045124;regulation of signaling#GO:0023051 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;lytic vacuole membrane#GO:0098852;lysosome#GO:0005764;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;vacuole#GO:0005773;cytoplasm#GO:0005737;membrane#GO:0016020;lysosomal membrane#GO:0005765;lytic vacuole#GO:0000323;vacuolar membrane#GO:0005774;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090 HUMAN|HGNC=1241|UniProtKB=P02745 P02745 C1QA PTHR15427:SF26 EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER COMPLEMENT C1Q SUBCOMPONENT SUBUNIT A receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546 biological regulation#GO:0065007;adaptive immune response#GO:0002250;positive regulation of response to stimulus#GO:0048584;positive regulation of biological process#GO:0048518;immune response#GO:0006955;complement activation#GO:0006956;activation of immune response#GO:0002253;positive regulation of immune system process#GO:0002684;positive regulation of immune response#GO:0050778;immune effector process#GO:0002252;regulation of response to stimulus#GO:0048583;humoral immune response#GO:0006959;response to stimulus#GO:0050896;regulation of immune system process#GO:0002682;regulation of biological process#GO:0050789;immunoglobulin mediated immune response#GO:0016064;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;regulation of immune response#GO:0050776;immune system process#GO:0002376 extracellular region#GO:0005576;extracellular protein-containing complex#GO:0140392;cellular anatomical structure#GO:0110165;synapse#GO:0045202;protein-containing complex#GO:0032991;cell junction#GO:0030054 scaffold/adaptor protein#PC00226 HUMAN|HGNC=11813|UniProtKB=Q9UNS1 Q9UNS1 TIMELESS PTHR22940:SF4 TIMEOUT/TIMELESS-2 PROTEIN TIMELESS HOMOLOG DNA binding#GO:0003677;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;DNA integrity checkpoint signaling#GO:0031570;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of DNA metabolic process#GO:0051053;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of cellular process#GO:0048523;negative regulation of DNA-templated DNA replication#GO:2000104;DNA repair#GO:0006281;negative regulation of cell cycle process#GO:0010948;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of cell cycle phase transition#GO:1901987;cellular response to stimulus#GO:0051716;regulation of DNA-templated DNA replication#GO:0090329;DNA replication#GO:0006260;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;response to stress#GO:0006950;cellular process#GO:0009987;signal transduction#GO:0007165;cell cycle checkpoint signaling#GO:0000075;regulation of cell cycle process#GO:0010564;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;negative regulation of cell cycle#GO:0045786;DNA replication checkpoint signaling#GO:0000076;negative regulation of cell cycle phase transition#GO:1901988;negative regulation of biological process#GO:0048519;regulation of DNA metabolic process#GO:0051052;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;negative regulation of metabolic process#GO:0009892;signaling#GO:0023052;regulation of cell cycle#GO:0051726;cellular response to stress#GO:0033554;DNA-templated DNA replication#GO:0006261;regulation of DNA replication#GO:0006275;negative regulation of nucleobase-containing compound metabolic process#GO:0045934 replication fork#GO:0005657;chromosome#GO:0005694;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular organelle#GO:0043229;nuclear replication fork#GO:0043596;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;protein-containing complex#GO:0032991;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228 HUMAN|HGNC=25132|UniProtKB=Q96H15 Q96H15 TIMD4 PTHR46608:SF3 T-CELL IMMUNOGLOBULIN AND MUCIN DOMAIN-CONTAINING PROTEIN 4 T-CELL IMMUNOGLOBULIN AND MUCIN DOMAIN-CONTAINING PROTEIN 4 phosphatidylserine binding#GO:0001786;lipid binding#GO:0008289;ion binding#GO:0043167;phospholipid binding#GO:0005543;small molecule binding#GO:0036094;binding#GO:0005488;anion binding#GO:0043168 phagocytosis#GO:0006909;transport#GO:0006810;establishment of localization#GO:0051234;import into cell#GO:0098657;endocytosis#GO:0006897;localization#GO:0051179;apoptotic cell clearance#GO:0043277 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=7892|UniProtKB=P00491 P00491 PNP PTHR11904:SF12 METHYLTHIOADENOSINE/PURINE NUCLEOSIDE PHOSPHORYLASE PURINE NUCLEOSIDE PHOSPHORYLASE glycosyltransferase activity#GO:0016757;transferase activity#GO:0016740;catalytic activity#GO:0003824;pentosyltransferase activity#GO:0016763 purine-containing compound catabolic process#GO:0072523;purine nucleoside catabolic process#GO:0006152;nucleobase-containing small molecule metabolic process#GO:0055086;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;cellular process#GO:0009987;nicotinamide nucleotide metabolic process#GO:0046496;nucleotide metabolic process#GO:0009117;nucleoside catabolic process#GO:0009164;nucleotide biosynthetic process#GO:0009165;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;small molecule metabolic process#GO:0044281;small molecule catabolic process#GO:0044282;phosphorus metabolic process#GO:0006793;nucleobase-containing small molecule catabolic process#GO:0034656;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;glycosyl compound catabolic process#GO:1901658;nucleobase-containing compound catabolic process#GO:0034655;NAD+ metabolic process#GO:0019674;organophosphate metabolic process#GO:0019637;carbohydrate derivative metabolic process#GO:1901135;organophosphate biosynthetic process#GO:0090407;purine nucleoside metabolic process#GO:0042278;pyridine-containing compound metabolic process#GO:0072524;nucleoside metabolic process#GO:0009116;catabolic process#GO:0009056;carbohydrate derivative catabolic process#GO:1901136;nucleoside phosphate metabolic process#GO:0006753;primary metabolic process#GO:0044238 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 nucleotide kinase#PC00172;kinase#PC00137 Xanthine and guanine salvage pathway#P02788>Guanosine phosphorylase#P03250;Adenine and hypoxanthine salvage pathway#P02723>Deoxyinosine phosphorylase#P02812;Adenine and hypoxanthine salvage pathway#P02723>Adenine phosphorylase#P02805;Purine metabolism#P02769>Nucleoside Phosphorylase#P03115;Adenine and hypoxanthine salvage pathway#P02723>Deoxyadenosine phosphorylase#P02808;Adenine and hypoxanthine salvage pathway#P02723>Inosine phosphorylase#P02813;Xanthine and guanine salvage pathway#P02788>Deoxyguanosine phosphorylase#P03248 HUMAN|HGNC=28398|UniProtKB=Q5T1N1 Q5T1N1 AKNAD1 PTHR21510:SF16 AKNA DOMAIN-CONTAINING PROTEIN PROTEIN AKNAD1 microtubule cytoskeleton#GO:0015630;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;supramolecular complex#GO:0099080;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512 HUMAN|HGNC=8992|UniProtKB=Q9Y237 Q9Y237 PIN4 PTHR45995:SF6 FAMILY NOT NAMED PEPTIDYL-PROLYL CIS-TRANS ISOMERASE NIMA-INTERACTING 4 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=5424|UniProtKB=P01568 P01568 IFNA21 PTHR11691:SF57 TYPE I INTERFERON INTERFERON ALPHA-21 signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;signaling receptor binding#GO:0005102;binding#GO:0005488;cytokine receptor binding#GO:0005126;cytokine activity#GO:0005125;protein-containing complex binding#GO:0044877;molecular function activator activity#GO:0140677;protein binding#GO:0005515 response to biotic stimulus#GO:0009607;response to stress#GO:0006950;signal transduction#GO:0007165;defense response to symbiont#GO:0140546;lymphocyte activation involved in immune response#GO:0002285;cellular process#GO:0009987;response to chemical#GO:0042221;response to cytokine#GO:0034097;lymphocyte activation#GO:0046649;defense response to other organism#GO:0098542;T cell activation involved in immune response#GO:0002286;humoral immune response#GO:0006959;leukocyte activation involved in immune response#GO:0002366;immune effector process#GO:0002252;cell surface receptor signaling pathway#GO:0007166;natural killer cell activation#GO:0030101;B cell activation#GO:0042113;T cell activation#GO:0042110;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;response to stimulus#GO:0050896;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;immune system process#GO:0002376;type I interferon-mediated signaling pathway#GO:0060337;B cell activation involved in immune response#GO:0002312;cell activation involved in immune response#GO:0002263;response to peptide#GO:1901652;immune response#GO:0006955;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;adaptive immune response#GO:0002250;response to other organism#GO:0051707;innate immune response#GO:0045087;response to external stimulus#GO:0009605;defense response#GO:0006952;leukocyte activation#GO:0045321;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;response to external biotic stimulus#GO:0043207;cytokine-mediated signaling pathway#GO:0019221;cell activation#GO:0001775;cell communication#GO:0007154;response to nitrogen compound#GO:1901698 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 interferon superfamily#PC00127;cytokine#PC00083 HUMAN|HGNC=6638|UniProtKB=Q03252 Q03252 LMNB2 PTHR45721:SF2 LAMIN DM0-RELATED LAMIN-B2 structural constituent of cytoskeleton#GO:0005200;structural molecule activity#GO:0005198 negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;cellular component assembly#GO:0022607;endomembrane system organization#GO:0010256;heterochromatin organization#GO:0070828;cellular component organization or biogenesis#GO:0071840;negative regulation of gene expression, epigenetic#GO:0045814;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;establishment of organelle localization#GO:0051656;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;cellular localization#GO:0051641;macromolecule localization#GO:0033036;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;protein localization to nucleus#GO:0034504;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;membrane organization#GO:0061024;negative regulation of biosynthetic process#GO:0009890;chromatin organization#GO:0006325;intracellular transport#GO:0046907;negative regulation of cellular process#GO:0048523;transport#GO:0006810;nucleus organization#GO:0006997;regulation of biosynthetic process#GO:0009889;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;nuclear envelope organization#GO:0006998;regulation of gene expression#GO:0010468;heterochromatin formation#GO:0031507;nuclear migration#GO:0007097;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;protein localization to organelle#GO:0033365;organelle localization#GO:0051640;localization within membrane#GO:0051668;localization#GO:0051179 organelle envelope#GO:0031967;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;endomembrane system#GO:0012505;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;nuclear periphery#GO:0034399;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 FAS signaling pathway#P00020>Nuclear Lamin#P00616 HUMAN|HGNC=13509|UniProtKB=Q9NQS1 Q9NQS1 AVEN PTHR16524:SF2 CELL DEATH REGULATOR AVEN CELL DEATH REGULATOR AVEN negative regulation of cell cycle G2/M phase transition#GO:1902750;negative regulation of cell cycle#GO:0045786;negative regulation of cell cycle process#GO:0010948;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;regulation of cell cycle process#GO:0010564;negative regulation of G2/M transition of mitotic cell cycle#GO:0010972;negative regulation of mitotic cell cycle phase transition#GO:1901991;regulation of mitotic cell cycle#GO:0007346;regulation of cell cycle G2/M phase transition#GO:1902749;negative regulation of mitotic cell cycle#GO:0045930;regulation of G2/M transition of mitotic cell cycle#GO:0010389;regulation of mitotic cell cycle phase transition#GO:1901990;regulation of cell cycle#GO:0051726;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of cell cycle phase transition#GO:1901988;regulation of cell cycle phase transition#GO:1901987;negative regulation of biological process#GO:0048519 HUMAN|HGNC=13564|UniProtKB=Q92563 Q92563 SPOCK2 PTHR13866:SF18 SPARC OSTEONECTIN TESTICAN-2 molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866;enzyme inhibitor activity#GO:0004857;cation binding#GO:0043169;molecular function inhibitor activity#GO:0140678;metal ion binding#GO:0046872;enzyme regulator activity#GO:0030234;calcium ion binding#GO:0005509;peptidase regulator activity#GO:0061134;endopeptidase regulator activity#GO:0061135;ion binding#GO:0043167;peptidase inhibitor activity#GO:0030414;small molecule binding#GO:0036094;binding#GO:0005488 regulation of cell-substrate adhesion#GO:0010810;biological regulation#GO:0065007;regulation of cell adhesion#GO:0030155;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576 extracellular matrix protein#PC00102;extracellular matrix glycoprotein#PC00100 HUMAN|HGNC=14583|UniProtKB=Q9H270 Q9H270 VPS11 PTHR23323:SF24 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11 HOMOLOG molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 cellular component organization or biogenesis#GO:0071840;vesicle organization#GO:0016050;endosome organization#GO:0007032;vacuole organization#GO:0007033;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;organelle fusion#GO:0048284;endomembrane system organization#GO:0010256 intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;vesicle#GO:0031982;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle tethering complex#GO:0099023;membrane#GO:0016020;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505 membrane trafficking regulatory protein#PC00151;membrane traffic protein#PC00150 HUMAN|HGNC=32487|UniProtKB=Q6NS38 Q6NS38 ALKBH2 PTHR31573:SF1 ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 2 DNA OXIDATIVE DEMETHYLASE ALKBH2 catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;oxidoreductase activity#GO:0016491;ion binding#GO:0043167;small molecule binding#GO:0036094;transition metal ion binding#GO:0046914;hydrolase activity#GO:0016787;dioxygenase activity#GO:0051213;cation binding#GO:0043169;ferrous iron binding#GO:0008198;catalytic activity, acting on DNA#GO:0140097;iron ion binding#GO:0005506;demethylase activity#GO:0032451;binding#GO:0005488;metal ion binding#GO:0046872 primary metabolic process#GO:0044238;response to stress#GO:0006950;nucleic acid metabolic process#GO:0090304;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;DNA damage response#GO:0006974;cellular response to stress#GO:0033554;macromolecule metabolic process#GO:0043170 oxygenase#PC00177 HUMAN|HGNC=5903|UniProtKB=P01714 P01714 IGLV3-19 PTHR23267:SF454 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN LAMBDA VARIABLE 3-19-RELATED response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 protein-containing complex#GO:0032991 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=2995|UniProtKB=Q9H3H5 Q9H3H5 DPAGT1 PTHR10571:SF0 UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE catalytic activity#GO:0003824;transferase activity#GO:0016740;phosphotransferase activity, for other substituted phosphate groups#GO:0016780;transferase activity, transferring phosphorus-containing groups#GO:0016772 cellular anatomical structure#GO:0110165;membrane#GO:0016020 glycosyltransferase#PC00111;transferase#PC00220 HUMAN|HGNC=9200|UniProtKB=O00411 O00411 POLRMT PTHR10102:SF28 DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;catalytic activity, acting on RNA#GO:0140098;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772 nucleic acid biosynthetic process#GO:0141187;mitochondrial gene expression#GO:0140053;RNA metabolic process#GO:0016070;mitochondrial RNA metabolic process#GO:0000959;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;mitochondrial transcription#GO:0006390;biosynthetic process#GO:0009058;gene expression#GO:0010467 intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;RNA polymerase complex#GO:0030880;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739 DNA-directed RNA polymerase#PC00019 HUMAN|HGNC=26771|UniProtKB=Q8N944 Q8N944 AMER3 PTHR22237:SF2 APC MEMBRANE RECRUITMENT PROTEIN 2-RELATED APC MEMBRANE RECRUITMENT PROTEIN 3 protein-membrane adaptor activity#GO:0043495;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 regulation of cellular process#GO:0050794;regulation of Wnt signaling pathway#GO:0030111;regulation of cell communication#GO:0010646;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of canonical Wnt signaling pathway#GO:0060828;regulation of biological process#GO:0050789;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HUMAN|HGNC=8212|UniProtKB=Q8NGR3 Q8NGR3 OR1K1 PTHR26451:SF965 G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN OLFACTORY RECEPTOR 1K1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488 response to stimulus#GO:0050896;response to chemical#GO:0042221;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;detection of chemical stimulus#GO:0009593;system process#GO:0003008;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;sensory perception#GO:0007600;nervous system process#GO:0050877 membrane#GO:0016020;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021 HUMAN|HGNC=26185|UniProtKB=Q9H6E4 Q9H6E4 CCDC134 PTHR14735:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 134 COILED-COIL DOMAIN-CONTAINING PROTEIN 134 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;endoplasmic reticulum lumen#GO:0005788;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 HUMAN|HGNC=26958|UniProtKB=Q8NDA8 Q8NDA8 MROH1 PTHR23120:SF44 MAESTRO-RELATED HEAT DOMAIN-CONTAINING MAESTRO HEAT-LIKE REPEAT-CONTAINING PROTEIN FAMILY MEMBER 1 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=16281|UniProtKB=Q96F44 Q96F44 TRIM11 PTHR24103:SF648 E3 UBIQUITIN-PROTEIN LIGASE TRIM E3 UBIQUITIN-PROTEIN LIGASE TRIM11 ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740 immune system process#GO:0002376;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;regulation of macromolecule metabolic process#GO:0060255;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;response to external stimulus#GO:0009605;defense response#GO:0006952;regulation of gene expression#GO:0010468;innate immune response#GO:0045087;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;response to other organism#GO:0051707;defense response to other organism#GO:0098542;defense response to symbiont#GO:0140546;immune response#GO:0006955;response to biotic stimulus#GO:0009607;regulation of macromolecule biosynthetic process#GO:0010556;response to stress#GO:0006950;regulation of metabolic process#GO:0019222 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=8985|UniProtKB=P20848 P20848 SERPINA2 PTHR11461:SF289 SERINE PROTEASE INHIBITOR, SERPIN ALPHA-1-ANTITRYPSIN-RELATED PROTEIN serine-type endopeptidase inhibitor activity#GO:0004867;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;peptidase regulator activity#GO:0061134;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414;molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866;enzyme inhibitor activity#GO:0004857 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HUMAN|HGNC=4710|UniProtKB=P20718 P20718 GZMH PTHR24271:SF70 KALLIKREIN-RELATED GRANZYME H hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;serine-type peptidase activity#GO:0008236;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity#GO:0003824 protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 serine protease#PC00203 Apoptosis signaling pathway#P00006>Granzyme B#P00265 HUMAN|HGNC=28538|UniProtKB=Q8NCF0 Q8NCF0 CLEC18C PTHR10334:SF521 CYSTEINE-RICH SECRETORY PROTEIN-RELATED C-TYPE LECTIN DOMAIN FAMILY 18 MEMBER A-RELATED polysaccharide binding#GO:0030247;binding#GO:0005488;carbohydrate binding#GO:0030246 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090 HUMAN|HGNC=19992|UniProtKB=Q6U736 Q6U736 OPN5 PTHR24240:SF0 OPSIN OPSIN-5 transmembrane signaling receptor activity#GO:0004888;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;response to light stimulus#GO:0009416;response to stimulus#GO:0050896;cellular response to environmental stimulus#GO:0104004;regulation of cellular process#GO:0050794;cellular response to radiation#GO:0071478;signaling#GO:0023052;response to abiotic stimulus#GO:0009628;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular response to abiotic stimulus#GO:0071214;response to external stimulus#GO:0009605;biological regulation#GO:0065007;detection of stimulus#GO:0051606;signal transduction#GO:0007165;cellular response to light stimulus#GO:0071482;response to radiation#GO:0009314;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HUMAN|HGNC=6220|UniProtKB=P16389 P16389 KCNA2 PTHR11537:SF23 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 2 potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261;voltage-gated monoatomic ion channel activity#GO:0005244;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873 monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;biological regulation#GO:0065007;potassium ion transport#GO:0006813;cellular process#GO:0009987;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;transport#GO:0006810;metal ion transport#GO:0030001;action potential#GO:0001508;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179 membrane#GO:0016020;presynapse#GO:0098793;neuron projection#GO:0043005;main axon#GO:0044304;cell periphery#GO:0071944;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;cation channel complex#GO:0034703;voltage-gated potassium channel complex#GO:0008076;cell junction#GO:0030054;transporter complex#GO:1990351;axon terminus#GO:0043679;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cellular anatomical structure#GO:0110165;synapse#GO:0045202;cell projection#GO:0042995;neuron projection terminus#GO:0044306;plasma membrane bounded cell projection#GO:0120025;distal axon#GO:0150034;dendrite#GO:0030425;axon#GO:0030424;dendritic tree#GO:0097447;transmembrane transporter complex#GO:1902495 ion channel#PC00133;voltage-gated ion channel#PC00241 HUMAN|HGNC=21390|UniProtKB=Q5TAB7 Q5TAB7 RIPPLY2 PTHR16770:SF3 PROTEIN RIPPLY-LIKE PROTEIN RIPPLY2 negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;embryo development#GO:0009790;embryonic pattern specification#GO:0009880;negative regulation of macromolecule biosynthetic process#GO:0010558;multicellular organism development#GO:0007275;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;pattern specification process#GO:0007389;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=6710|UniProtKB=P09960 P09960 LTA4H PTHR45726:SF7 LEUKOTRIENE A-4 HYDROLASE LEUKOTRIENE A-4 HYDROLASE catalytic activity#GO:0003824;aminopeptidase activity#GO:0004177;catalytic activity, acting on a protein#GO:0140096;exopeptidase activity#GO:0008238;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;ether hydrolase activity#GO:0016803 metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;small molecule biosynthetic process#GO:0044283;peptide metabolic process#GO:0006518;carboxylic acid metabolic process#GO:0019752;peptide catabolic process#GO:0043171;carboxylic acid biosynthetic process#GO:0046394;cellular process#GO:0009987;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;icosanoid metabolic process#GO:0006690;biosynthetic process#GO:0009058;icosanoid biosynthetic process#GO:0046456 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 HUMAN|HGNC=34410|UniProtKB=Q96JN8 Q96JN8 NEURL4 PTHR12429:SF14 NEURALIZED NEURALIZED-LIKE PROTEIN 4 acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 Notch signaling pathway#P00045>Neuralized#P01117 HUMAN|HGNC=1815|UniProtKB=P40198 P40198 CEACAM3 PTHR44427:SF23 CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 19 CELL ADHESION MOLECULE CEACAM3 kinase binding#GO:0019900;binding#GO:0005488;protein tyrosine kinase binding#GO:1990782;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;protein binding#GO:0005515 cell communication#GO:0007154;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cell surface#GO:0009986;cellular anatomical structure#GO:0110165 cell adhesion molecule#PC00069 HUMAN|HGNC=28236|UniProtKB=Q5T5S1 Q5T5S1 CCDC183 PTHR47115:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 183 COILED-COIL DOMAIN-CONTAINING PROTEIN 183 HUMAN|HGNC=30242|UniProtKB=Q13454 Q13454 TUSC3 PTHR12692:SF1 DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE-RELATED DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT TUSC3 protein N-linked glycosylation#GO:0006487;primary metabolic process#GO:0044238;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;protein metabolic process#GO:0019538;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;glycoprotein biosynthetic process#GO:0009101;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;monoatomic ion transmembrane transport#GO:0034220;biosynthetic process#GO:0009058;monoatomic cation transmembrane transport#GO:0098655;metabolic process#GO:0008152;magnesium ion transport#GO:0015693;transport#GO:0006810;glycoprotein metabolic process#GO:0009100;carbohydrate derivative biosynthetic process#GO:1901137;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170 organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;oligosaccharyltransferase complex#GO:0008250;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;endoplasmic reticulum protein-containing complex#GO:0140534;organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;transferase complex#GO:1990234;endoplasmic reticulum#GO:0005783;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasm#GO:0005737;membrane#GO:0016020 transferase#PC00220;glycosyltransferase#PC00111 HUMAN|HGNC=14362|UniProtKB=Q7Z5P9 Q7Z5P9 MUC19 PTHR47246:SF1 MUCIN-19 MUCIN-19 HUMAN|HGNC=29290|UniProtKB=Q9P244 Q9P244 LRFN1 PTHR45842:SF7 SYNAPTIC ADHESION-LIKE MOLECULE SALM LEUCINE-RICH REPEAT AND FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN 1 synaptic membrane#GO:0097060;cell junction#GO:0030054;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;neuron to neuron synapse#GO:0098984;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;postsynaptic density#GO:0014069;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;postsynaptic density membrane#GO:0098839;postsynapse#GO:0098794;cellular anatomical structure#GO:0110165;synapse#GO:0045202;asymmetric synapse#GO:0032279;organelle#GO:0043226 immunoglobulin superfamily cell adhesion molecule#PC00125;cell adhesion molecule#PC00069 HUMAN|HGNC=16894|UniProtKB=Q14728 Q14728 SLC75A1 PTHR23504:SF121 MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10 SOLUTE CARRIER FAMILY 75 MEMBER 1 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 cellular process#GO:0009987;transport#GO:0006810;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179 apical plasma membrane#GO:0016324;membrane#GO:0016020;cell periphery#GO:0071944;brush border#GO:0005903;plasma membrane region#GO:0098590;brush border membrane#GO:0031526;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;apical part of cell#GO:0045177;cell projection membrane#GO:0031253;cluster of actin-based cell projections#GO:0098862 secondary carrier transporter#PC00258;transporter#PC00227 HUMAN|HGNC=14089|UniProtKB=Q9HCS7 Q9HCS7 XAB2 PTHR11246:SF5 PRE-MRNA SPLICING FACTOR PRE-MRNA-SPLICING FACTOR SYF1 protein-containing complex assembly#GO:0065003;mRNA splicing, via spliceosome#GO:0000398;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;ribonucleoprotein complex biogenesis#GO:0022613;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;protein-RNA complex assembly#GO:0022618;RNA metabolic process#GO:0016070;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;cellular component biogenesis#GO:0044085;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular component assembly#GO:0022607;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;protein-containing complex organization#GO:0043933;protein-RNA complex organization#GO:0071826;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170 nuclear protein-containing complex#GO:0140513;catalytic step 2 spliceosome#GO:0071013;post-mRNA release spliceosomal complex#GO:0071014;nucleus#GO:0005634;protein-containing complex#GO:0032991;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;Prp19 complex#GO:0000974;intracellular anatomical structure#GO:0005622;spliceosomal complex#GO:0005681;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;U2-type spliceosomal complex#GO:0005684 RNA processing factor#PC00147;RNA splicing factor#PC00148 HUMAN|HGNC=12193|UniProtKB=A0A087X0M5 A0A087X0M5 TRBV18 PTHR23268:SF88 T-CELL RECEPTOR BETA CHAIN T CELL RECEPTOR BETA VARIABLE 18 cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=14766|UniProtKB=Q8NGJ3 Q8NGJ3 OR52E1 PTHR26450:SF3 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 52E1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|Ensembl=ENSG00000275949.5|UniProtKB=A0A0G2JMH3 A0A0G2JMH3 LOC107984156 PTHR11711:SF347 ADP RIBOSYLATION FACTOR-RELATED ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 17 C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;nucleotide binding#GO:0000166;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;guanyl nucleotide binding#GO:0019001;nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;anion binding#GO:0043168;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525 transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;protein transport#GO:0015031;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;macromolecule localization#GO:0033036;vesicle-mediated transport#GO:0016192 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 G-protein#PC00020 HUMAN|HGNC=22423|UniProtKB=Q96H79 Q96H79 ZC3HAV1L PTHR47621:SF1 ZINC FINGER CCCH-TYPE ANTIVIRAL PROTEIN 1-LIKE ZINC FINGER CCCH-TYPE ANTIVIRAL PROTEIN 1-LIKE HUMAN|HGNC=14912|UniProtKB=Q9NYW4 Q9NYW4 TAS2R5 PTHR11394:SF8 TASTE RECEPTOR TYPE 2 TASTE RECEPTOR TYPE 2 MEMBER 5 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;taste receptor activity#GO:0008527;molecular transducer activity#GO:0060089;bitter taste receptor activity#GO:0033038 detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;sensory perception of bitter taste#GO:0050913;detection of chemical stimulus#GO:0009593;response to stimulus#GO:0050896;response to chemical#GO:0042221;multicellular organismal process#GO:0032501;sensory perception of taste#GO:0050909;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;sensory perception#GO:0007600;detection of chemical stimulus involved in sensory perception of taste#GO:0050912;nervous system process#GO:0050877;detection of chemical stimulus involved in sensory perception of bitter taste#GO:0001580;system process#GO:0003008 cellular anatomical structure#GO:0110165;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=11534|UniProtKB=Q15572 Q15572 TAF1C PTHR15319:SF1 TATA BOX-BINDING PROTEIN ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT C TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT C sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;core promoter sequence-specific DNA binding#GO:0001046;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488 nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 General transcription by RNA polymerase I#P00022>SL1 complex#P00653;Transcription regulation by bZIP transcription factor#P00055>TBP-associated factors#P01385;General transcription by RNA polymerase I#P00022>TAF-IC#P00649;General transcription regulation#P00023>TBP-associated factors#P00658 HUMAN|HGNC=679|UniProtKB=P52566 P52566 ARHGDIB PTHR10980:SF15 RHO GDP-DISSOCIATION INHIBITOR RHO GDP-DISSOCIATION INHIBITOR 2 molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;intracellular signaling cassette#GO:0141124;cell communication#GO:0007154;Rho protein signal transduction#GO:0007266;intracellular signal transduction#GO:0035556 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;membrane#GO:0016020;cytosol#GO:0005829 protein-binding activity modulator#PC00095;G-protein modulator#PC00022 HUMAN|HGNC=16235|UniProtKB=Q9H3Z4 Q9H3Z4 DNAJC5 PTHR44027:SF1 DNAJ HOMOLOG SUBFAMILY C MEMBER 5 HOMOLOG DNAJ HOMOLOG SUBFAMILY C MEMBER 5 metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;regulation of transport#GO:0051049;regulation of localization#GO:0032879;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;protein maturation#GO:0051604;biological regulation#GO:0065007;biosynthetic process#GO:0009058;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;protein folding#GO:0006457 organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;presynapse#GO:0098793;cell junction#GO:0030054;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 chaperone#PC00072 HUMAN|HGNC=18472|UniProtKB=Q9C0B5 Q9C0B5 ZDHHC5 PTHR12349:SF3 ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2 PALMITOYLTRANSFERASE ZDHHC5 acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824;palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of response to stimulus#GO:0048584;regulation of response to external stimulus#GO:0032101;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of innate immune response#GO:0045089;positive regulation of immune system process#GO:0002684;positive regulation of pattern recognition receptor signaling pathway#GO:0062208;positive regulation of response to biotic stimulus#GO:0002833;regulation of innate immune response#GO:0045088;positive regulation of response to external stimulus#GO:0032103;positive regulation of defense response#GO:0031349;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;regulation of response to stress#GO:0080134;regulation of response to biotic stimulus#GO:0002831;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;positive regulation of cell communication#GO:0010647;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;positive regulation of signaling#GO:0023056;regulation of immune response#GO:0050776;regulation of defense response#GO:0031347;regulation of signaling#GO:0023051 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HUMAN|HGNC=23208|UniProtKB=Q9GZM3 Q9GZM3 POLR2J2 PTHR13946:SF48 DNA-DIRECTED RNA POLYMERASE I,II,III DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11-B1-RELATED nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on RNA#GO:0140098 transcription by RNA polymerase II#GO:0006366;nucleic acid biosynthetic process#GO:0141187;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467 intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234;protein-containing complex#GO:0032991;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;membrane-bounded organelle#GO:0043227;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;RNA polymerase II, holoenzyme#GO:0016591;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;RNA polymerase II, core complex#GO:0005665;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 HUMAN|HGNC=26323|UniProtKB=Q8N283 Q8N283 ANKRD35 PTHR24161:SF21 ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 35 protein modifying enzyme#PC00260 HUMAN|HGNC=9004|UniProtKB=P78337 P78337 PITX1 PTHR45882:SF1 PITUITARY HOMEOBOX HOMOLOG PTX1 PITUITARY HOMEOBOX 1 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119 Gonadotropin-releasing hormone receptor pathway#P06664>PITX#P06722 HUMAN|HGNC=6990|UniProtKB=P51608 P51608 MECP2 PTHR15074:SF6 METHYL-CPG-BINDING PROTEIN METHYL-CPG-BINDING PROTEIN 2 DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;small molecule binding#GO:0036094;binding#GO:0005488;nucleoside phosphate binding#GO:1901265;chromatin binding#GO:0003682;heterocyclic compound binding#GO:1901363;sequence-specific DNA binding#GO:0043565;nucleotide binding#GO:0000166 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519 chromosome#GO:0005694;chromatin#GO:0000785;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;heterochromatin#GO:0000792;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=17041|UniProtKB=O95757 O95757 HSPA4L PTHR45639:SF5 HSC70CB, ISOFORM G-RELATED HEAT SHOCK 70 KDA PROTEIN 4L molecular function regulator activity#GO:0098772;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein folding#GO:0006457;biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 Hsp70 family chaperone#PC00027;chaperone#PC00072 HUMAN|HGNC=16089|UniProtKB=O15173 O15173 PGRMC2 PTHR10281:SF24 MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT 2 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 transmembrane signal receptor#PC00197 HUMAN|HGNC=6037|UniProtKB=Q12905 Q12905 ILF2 PTHR46447:SF1 INTERLEUKIN ENHANCER-BINDING FACTOR INTERLEUKIN ENHANCER-BINDING FACTOR 2 RNA binding#GO:0003723;DNA binding#GO:0003677;double-stranded RNA binding#GO:0003725;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of DNA-templated transcription#GO:0006355;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007 transcription cofactor#PC00217 HUMAN|HGNC=10905|UniProtKB=Q14973 Q14973 SLC10A1 PTHR10361:SF40 SODIUM-BILE ACID COTRANSPORTER HEPATIC SODIUM_BILE ACID COTRANSPORTER solute:sodium symporter activity#GO:0015370;monoatomic cation transmembrane transporter activity#GO:0008324;bile acid transmembrane transporter activity#GO:0015125;carboxylic acid transmembrane transporter activity#GO:0046943;symporter activity#GO:0015293;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;secondary active transmembrane transporter activity#GO:0015291 lipid transport#GO:0006869;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;localization#GO:0051179;monocarboxylic acid transport#GO:0015718;organic hydroxy compound transport#GO:0015850;lipid localization#GO:0010876;carboxylic acid transport#GO:0046942;organic acid transport#GO:0015849;transport#GO:0006810;bile acid and bile salt transport#GO:0015721 membrane#GO:0016020;basal part of cell#GO:0045178;basolateral plasma membrane#GO:0016323;cell periphery#GO:0071944;basal plasma membrane#GO:0009925;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;plasma membrane#GO:0005886 primary active transporter#PC00068 HUMAN|HGNC=8076|UniProtKB=O95156 O95156 NXPH2 PTHR17103:SF11 NEUREXOPHILIN NEUREXOPHILIN-2 protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488 regulation of biological process#GO:0050789;regulation of signaling#GO:0023051;modulation of chemical synaptic transmission#GO:0050804;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;regulation of trans-synaptic signaling#GO:0099177;regulation of cellular process#GO:0050794 cell junction#GO:0030054;synapse#GO:0045202;cellular anatomical structure#GO:0110165;GABA-ergic synapse#GO:0098982 intercellular signal molecule#PC00207 HUMAN|HGNC=13525|UniProtKB=Q9UQF0 Q9UQF0 ERVW-1 PTHR10424:SF48 VIRAL ENVELOPE PROTEIN SYNCYTIN-1 cell differentiation#GO:0030154;muscle structure development#GO:0061061;muscle cell differentiation#GO:0042692;cellular process#GO:0009987;myoblast fusion#GO:0007520;striated muscle cell differentiation#GO:0051146;syncytium formation by cell-cell fusion#GO:0000768;cellular developmental process#GO:0048869;anatomical structure development#GO:0048856;developmental process#GO:0032502;cell-cell fusion#GO:0140253;animal gross anatomical part developmental process#GO:0160108 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 viral or transposable element protein#PC00237 HUMAN|HGNC=8557|UniProtKB=Q13310 Q13310 PABPC4 PTHR24012:SF365 RNA BINDING PROTEIN POLYADENYLATE-BINDING PROTEIN 4 nucleic acid binding#GO:0003676;poly(A) binding#GO:0008143;binding#GO:0005488;mRNA binding#GO:0003729;mRNA 3'-UTR binding#GO:0003730;single-stranded RNA binding#GO:0003727;RNA binding#GO:0003723 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;post-transcriptional regulation of gene expression#GO:0010608 cytosol#GO:0005829;nucleus#GO:0005634;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;membraneless organelle#GO:0043228;cytoplasmic stress granule#GO:0010494;organelle#GO:0043226;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HUMAN|HGNC=16102|UniProtKB=Q96KR6 Q96KR6 MIMS2 PTHR21377:SF16 PROTEIN FAM210B, MITOCHONDRIAL MITOCHONDRIAL INNER MEMBRANE SCAFFOLD 2 intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966 HUMAN|HGNC=26296|UniProtKB=Q5U5Z8 Q5U5Z8 AGBL2 PTHR12756:SF41 CYTOSOLIC CARBOXYPEPTIDASE CYTOSOLIC CARBOXYPEPTIDASE 2 catalytic activity#GO:0003824;metalloexopeptidase activity#GO:0008235;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;binding#GO:0005488;metallopeptidase activity#GO:0008237;hydrolase activity#GO:0016787;metallocarboxypeptidase activity#GO:0004181;protein binding#GO:0005515;exopeptidase activity#GO:0008238;carboxypeptidase activity#GO:0004180 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;centriole#GO:0005814;cellular anatomical structure#GO:0110165;organelle#GO:0043226 metalloprotease#PC00153 HUMAN|HGNC=8238|UniProtKB=O76000 O76000 OR2B3 PTHR26453:SF103 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2B3-RELATED olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 system process#GO:0003008;sensory perception#GO:0007600;nervous system process#GO:0050877;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;response to chemical#GO:0042221;response to stimulus#GO:0050896;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;detection of chemical stimulus#GO:0009593;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=26507|UniProtKB=Q1HG43 Q1HG43 DUOXA1 PTHR31158:SF3 DUAL OXIDASE 2 DUAL OXIDASE MATURATION FACTOR 1 cellular anatomical structure#GO:0110165;membrane#GO:0016020 oxidoreductase#PC00176;oxidase#PC00175 HUMAN|HGNC=24093|UniProtKB=Q6UW32 Q6UW32 IGFL1 PTHR34827:SF2 INSULIN GROWTH FACTOR-LIKE FAMILY MEMBER 3-RELATED INSULIN GROWTH FACTOR-LIKE FAMILY MEMBER 1 binding#GO:0005488;signaling receptor binding#GO:0005102;protein binding#GO:0005515 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207;growth factor#PC00112 HUMAN|HGNC=20782|UniProtKB=Q6UX68 Q6UX68 XKR5 PTHR16024:SF15 XK-RELATED PROTEIN XK-RELATED PROTEIN 5 endomembrane system organization#GO:0010256;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;phagocytosis, engulfment#GO:0006911;apoptotic cell clearance#GO:0043277;import into cell#GO:0098657;membrane invagination#GO:0010324;endocytosis#GO:0006897;cellular component organization#GO:0016043;execution phase of apoptosis#GO:0097194;apoptotic process#GO:0006915;plasma membrane organization#GO:0007009;regulation of biological quality#GO:0065008;lipid localization#GO:0010876;lipid transport#GO:0006869;membrane organization#GO:0061024;phospholipid translocation#GO:0045332;phospholipid transport#GO:0015914;biological regulation#GO:0065007;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;regulation of membrane lipid distribution#GO:0097035;phagocytosis#GO:0006909;developmental process#GO:0032502;transport#GO:0006810;organophosphate ester transport#GO:0015748;lipid translocation#GO:0034204;plasma membrane phospholipid scrambling#GO:0017121;programmed cell death#GO:0012501;cell death#GO:0008219;localization#GO:0051179;anatomical structure development#GO:0048856 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 secondary carrier transporter#PC00258 HUMAN|HGNC=25802|UniProtKB=Q8N4W6 Q8N4W6 DNAJC22 PTHR44733:SF1 DNAJ HOMOLOG SUBFAMILY C MEMBER 22 DNAJ HOMOLOG SUBFAMILY C MEMBER 22 cellular anatomical structure#GO:0110165;membrane#GO:0016020 chaperone#PC00072 HUMAN|HGNC=22432|UniProtKB=Q9BWK5 Q9BWK5 CYREN PTHR14566:SF0 CELL CYCLE REGULATOR OF NON-HOMOLOGOUS END JOINING CELL CYCLE REGULATOR OF NON-HOMOLOGOUS END JOINING double-strand break repair via nonhomologous end joining#GO:0006303;macromolecule metabolic process#GO:0043170;double-strand break repair#GO:0006302;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;site of DNA damage#GO:0090734;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;nucleus#GO:0005634;chromosome#GO:0005694;site of double-strand break#GO:0035861;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=17352|UniProtKB=Q9UH17 Q9UH17 APOBEC3B PTHR13857:SF39 MRNA EDITING ENZYME DNA DC-DU-EDITING ENZYME APOBEC-3B hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;deaminase activity#GO:0019239;catalytic activity#GO:0003824;RNA binding#GO:0003723;hydrolase activity#GO:0016787;binding#GO:0005488;nucleic acid binding#GO:0003676 cellular process#GO:0009987;response to stress#GO:0006950;negative regulation of macromolecule biosynthetic process#GO:0010558;response to biotic stimulus#GO:0009607;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;regulation of biological process#GO:0050789;defense response to virus#GO:0051607;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;RNA modification#GO:0009451;base conversion or substitution editing#GO:0016553;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;RNA metabolic process#GO:0016070;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;response to other organism#GO:0051707;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of cellular process#GO:0048523;defense response#GO:0006952;response to external stimulus#GO:0009605;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;nucleic acid metabolic process#GO:0090304;cytidine to uridine editing#GO:0016554;primary metabolic process#GO:0044238;response to external biotic stimulus#GO:0043207;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;response to virus#GO:0009615;macromolecule modification#GO:0043412 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;P-body#GO:0000932;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;supramolecular complex#GO:0099080;organelle#GO:0043226;ribonucleoprotein granule#GO:0035770;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;nucleus#GO:0005634 RNA processing factor#PC00147 HUMAN|HGNC=17791|UniProtKB=O95759 O95759 TBC1D8 PTHR22957:SF260 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN TBC1 DOMAIN FAMILY MEMBER 8 molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;enzyme activator activity#GO:0008047 protein-binding activity modulator#PC00095;G-protein modulator#PC00022;GTPase-activating protein#PC00257 HUMAN|HGNC=17824|UniProtKB=Q9NWW9 Q9NWW9 PLAAT2 PTHR13943:SF33 HRAS-LIKE SUPPRESSOR - RELATED PHOSPHOLIPASE A AND ACYLTRANSFERASE 2 transferase activity#GO:0016740;catalytic activity#GO:0003824;glycerophospholipase activity#GO:0004620;hydrolase activity, acting on ester bonds#GO:0016788;phospholipase activity#GO:0120569;A2-type glycerophospholipase activity#GO:0004623;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acyltransferase activity#GO:0016746;lipase activity#GO:0016298;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity#GO:0016787 organophosphate metabolic process#GO:0019637;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;cellular process#GO:0009987;glycerolipid metabolic process#GO:0046486;glycerophospholipid metabolic process#GO:0006650;phospholipid metabolic process#GO:0006644;metabolic process#GO:0008152;lipid metabolic process#GO:0006629 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 acyltransferase#PC00042;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=2039|UniProtKB=P56856 P56856 CLDN18 PTHR12002:SF9 CLAUDIN CLAUDIN-18 cell-cell junction assembly#GO:0007043;cell-cell junction organization#GO:0045216;cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;cell junction assembly#GO:0034329;cellular process#GO:0009987;cell junction organization#GO:0034330;cellular component assembly#GO:0022607 cell periphery#GO:0071944;membrane#GO:0016020;cell-cell junction#GO:0005911;plasma membrane#GO:0005886;bicellular tight junction#GO:0005923;cellular anatomical structure#GO:0110165;apical junction complex#GO:0043296;anchoring junction#GO:0070161;cell junction#GO:0030054;tight junction#GO:0070160 cell junction protein#PC00070;tight junction#PC00214 HUMAN|HGNC=26789|UniProtKB=Q8IV20 Q8IV20 LACC1 PTHR30616:SF5 UNCHARACTERIZED PROTEIN YFIH PURINE NUCLEOSIDE PHOSPHORYLASE LACC1 transferase activity#GO:0016740;catalytic activity#GO:0003824;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;glycosyltransferase activity#GO:0016757;deaminase activity#GO:0019239;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;pentosyltransferase activity#GO:0016763;hydrolase activity#GO:0016787;adenosine deaminase activity#GO:0004000 innate immune response-activating signaling pathway#GO:0002758;cellular response to stimulus#GO:0051716;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of response to biotic stimulus#GO:0002831;regulation of immune response#GO:0050776;regulation of defense response#GO:0031347;cell communication#GO:0007154;activation of innate immune response#GO:0002218;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;positive regulation of innate immune response#GO:0045089;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of response to stress#GO:0080134;positive regulation of immune response#GO:0050778;positive regulation of defense response#GO:0031349;regulation of response to stimulus#GO:0048583;regulation of innate immune response#GO:0045088;positive regulation of response to biotic stimulus#GO:0002833;pattern recognition receptor signaling pathway#GO:0002221;regulation of biological process#GO:0050789;immune response-regulating signaling pathway#GO:0002764;response to stimulus#GO:0050896;signaling#GO:0023052;immune system process#GO:0002376;positive regulation of immune system process#GO:0002684;signal transduction#GO:0007165;activation of immune response#GO:0002253;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of response to external stimulus#GO:0032101;immune response-activating signaling pathway#GO:0002757;positive regulation of response to external stimulus#GO:0032103 microbody#GO:0042579;peroxisome#GO:0005777;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=9234|UniProtKB=Q15648 Q15648 MED1 PTHR12881:SF16 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1 DNA-binding transcription factor binding#GO:0140297;protein binding#GO:0005515;RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629;transcription regulator activity#GO:0140110;binding#GO:0005488;transcription coregulator activity#GO:0003712;nuclear receptor binding#GO:0016922;transcription factor binding#GO:0008134 cellular response to chemical stimulus#GO:0070887;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;regulation of macromolecule metabolic process#GO:0060255;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;cellular response to hormone stimulus#GO:0032870;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;response to hormone#GO:0009725;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;response to chemical#GO:0042221;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mediator complex#GO:0016592;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 general transcription factor#PC00259 HUMAN|HGNC=4935|UniProtKB=P28068 P28068 HLA-DMB PTHR19944:SF65 MHC CLASS II-RELATED HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DM BETA CHAIN protein-containing complex binding#GO:0044877;peptide binding#GO:0042277;antigen binding#GO:0003823;binding#GO:0005488 positive regulation of cell adhesion#GO:0045785;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of cell-cell adhesion#GO:0022407;regulation of immune response#GO:0050776;antigen processing and presentation#GO:0019882;positive regulation of lymphocyte activation#GO:0051251;positive regulation of cellular process#GO:0048522;regulation of cell adhesion#GO:0030155;positive regulation of response to stimulus#GO:0048584;positive regulation of cell activation#GO:0050867;positive regulation of leukocyte cell-cell adhesion#GO:1903039;biological regulation#GO:0065007;regulation of leukocyte cell-cell adhesion#GO:1903037;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;cellular component organization#GO:0016043;regulation of leukocyte activation#GO:0002694;regulation of cell activation#GO:0050865;positive regulation of multicellular organismal process#GO:0051240;protein-containing complex assembly#GO:0065003;regulation of biological process#GO:0050789;regulation of lymphocyte activation#GO:0051249;immune system process#GO:0002376;positive regulation of immune system process#GO:0002684;cellular component biogenesis#GO:0044085;positive regulation of cell-cell adhesion#GO:0022409;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;regulation of T cell activation#GO:0050863;cellular component assembly#GO:0022607;positive regulation of T cell activation#GO:0050870;regulation of multicellular organismal process#GO:0051239;positive regulation of leukocyte activation#GO:0002696;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933 vesicle#GO:0031982;lysosome#GO:0005764;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;lytic vacuole membrane#GO:0098852;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endosome membrane#GO:0010008;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;cell periphery#GO:0071944;lysosomal membrane#GO:0005765;vesicle membrane#GO:0012506;membrane#GO:0016020;plasma membrane#GO:0005886;vacuole#GO:0005773;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;late endosome#GO:0005770;protein-containing complex#GO:0032991;late endosome membrane#GO:0031902;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;lytic vacuole#GO:0000323;vacuolar membrane#GO:0005774 major histocompatibility complex protein#PC00149 T cell activation#P00053>MHC-antigen#P01316 HUMAN|HGNC=9886|UniProtKB=P29375 P29375 KDM5A PTHR10694:SF17 LYSINE-SPECIFIC DEMETHYLASE LYSINE-SPECIFIC DEMETHYLASE 5A catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;histone demethylase activity#GO:0032452;catalytic activity, acting on a protein#GO:0140096;demethylase activity#GO:0032451;oxidoreductase activity#GO:0016491;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;protein demethylase activity#GO:0140457;dioxygenase activity#GO:0051213;histone modifying activity#GO:0140993 regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;chromatin remodeling#GO:0006338;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468;regulation of nucleobase-containing compound metabolic process#GO:0019219;chromatin organization#GO:0006325;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987 membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;chromatin#GO:0000785;nucleus#GO:0005634 histone modifying enzyme#PC00261 HUMAN|HGNC=6256|UniProtKB=P78508 P78508 KCNJ10 PTHR11767:SF21 INWARD RECTIFIER POTASSIUM CHANNEL ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 10 monoatomic cation channel activity#GO:0005261;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276;potassium channel activity#GO:0005267;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;transporter activity#GO:0005215;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249 potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813;cellular process#GO:0009987;inorganic cation import across plasma membrane#GO:0098659;potassium ion import across plasma membrane#GO:1990573;establishment of localization#GO:0051234;import into cell#GO:0098657;transport#GO:0006810;metal ion transport#GO:0030001;inorganic ion import across plasma membrane#GO:0099587;import across plasma membrane#GO:0098739;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133 HUMAN|HGNC=5024|UniProtKB=P41235 P41235 HNF4A PTHR24083:SF41 NUCLEAR HORMONE RECEPTOR HEPATOCYTE NUCLEAR FACTOR 4-ALPHA sequence-specific double-stranded DNA binding#GO:1990837;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;nuclear receptor activity#GO:0004879;cis-regulatory region sequence-specific DNA binding#GO:0000987;molecular transducer activity#GO:0060089;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;signaling receptor activity#GO:0038023;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulator activity#GO:0140110;transcription regulatory region nucleic acid binding#GO:0001067 regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;positive regulation of transcription by RNA polymerase II#GO:0045944;developmental process#GO:0032502;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of DNA-templated transcription#GO:0006355;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C4 zinc finger nuclear receptor#PC00169;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=10536|UniProtKB=Q9UL12 Q9UL12 SARDH PTHR13847:SF200 SARCOSINE DEHYDROGENASE-RELATED SARCOSINE DEHYDROGENASE, MITOCHONDRIAL catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233 dehydrogenase#PC00092 HUMAN|HGNC=4042|UniProtKB=Q9ULV1 Q9ULV1 FZD4 PTHR11309:SF23 FRIZZLED FRIZZLED-4 signaling receptor activity#GO:0038023;Wnt-protein binding#GO:0017147;molecular transducer activity#GO:0060089;protein binding#GO:0005515;transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488 retina development in camera-type eye#GO:0060041;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;cellular process#GO:0009987;signal transduction#GO:0007165;sensory system development#GO:0048880;vasculature development#GO:0001944;animal organ development#GO:0048513;multicellular organism development#GO:0007275;cell surface receptor signaling pathway#GO:0007166;developmental process#GO:0032502;sensory organ development#GO:0007423;visual system development#GO:0150063;signaling#GO:0023052;regulation of cellular process#GO:0050794;Wnt signaling pathway#GO:0016055;circulatory system development#GO:0072359;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;non-canonical Wnt signaling pathway#GO:0035567;eye development#GO:0001654;system development#GO:0048731;anatomical structure development#GO:0048856;canonical Wnt signaling pathway#GO:0060070;cell communication#GO:0007154;animal gross anatomical part developmental process#GO:0160108;camera-type eye development#GO:0043010 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 Alzheimer disease-presenilin pathway#P00004>Frizzled#P00119;Wnt signaling pathway#P00057>Frizzled#P01428;Cadherin signaling pathway#P00012>Frizzled#P00475 HUMAN|HGNC=29535|UniProtKB=Q9Y483 Q9Y483 MTF2 PTHR12628:SF12 POLYCOMB-LIKE TRANSCRIPTION FACTOR METAL-RESPONSE ELEMENT-BINDING TRANSCRIPTION FACTOR 2 DNA binding#GO:0003677;chromatin binding#GO:0003682;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of gene expression, epigenetic#GO:0045814;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;chromatin organization#GO:0006325;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=27849|UniProtKB=Q9BUH6 Q9BUH6 PAXX PTHR28586:SF1 PROTEIN PAXX PROTEIN PAXX cellular process#GO:0009987;cellular response to stimulus#GO:0051716;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;primary metabolic process#GO:0044238;nucleobase-containing compound metabolic process#GO:0006139;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;double-strand break repair via nonhomologous end joining#GO:0006303 membraneless organelle#GO:0043228;intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;site of double-strand break#GO:0035861;nucleus#GO:0005634;DNA repair complex#GO:1990391;intracellular anatomical structure#GO:0005622;site of DNA damage#GO:0090734;membrane-bounded organelle#GO:0043227;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nonhomologous end joining complex#GO:0070419;chromosome#GO:0005694 HUMAN|HGNC=12756|UniProtKB=P57081 P57081 WDR4 PTHR16288:SF0 WD40 REPEAT PROTEIN 4 TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT WDR4 tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;RNA biosynthetic process#GO:0032774;tRNA modification#GO:0006400;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 nucleus#GO:0005634;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;methyltransferase complex#GO:0034708;transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 RNA metabolism protein#PC00031;RNA processing factor#PC00147 HUMAN|HGNC=31456|UniProtKB=Q5TBE3 Q5TBE3 C9orf153 PTHR37353:SF1 RIKEN CDNA 4921517D22 GENE RIKEN CDNA 4921517D22 GENE HUMAN|HGNC=28562|UniProtKB=Q8N309 Q8N309 LRRC43 PTHR45973:SF35 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED LEUCINE-RICH REPEAT-CONTAINING PROTEIN 43 protein-binding activity modulator#PC00095;phosphatase modulator#PC00184 HUMAN|HGNC=26129|UniProtKB=Q86YV0 Q86YV0 RASAL3 PTHR10194:SF96 RAS GTPASE-ACTIVATING PROTEINS RAS PROTEIN ACTIVATOR LIKE-3 GTPase-activating protein#PC00257 HUMAN|HGNC=11763|UniProtKB=P02786 P02786 TFRC PTHR10404:SF26 N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE TRANSFERRIN RECEPTOR PROTEIN 1 peptidase activity#GO:0008233;carboxypeptidase activity#GO:0004180;exopeptidase activity#GO:0008238;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;catalytic activity#GO:0003824 metalloprotease#PC00153 HUMAN|HGNC=427|UniProtKB=Q9UM73 Q9UM73 ALK PTHR24416:SF276 TYROSINE-PROTEIN KINASE RECEPTOR ALK TYROSINE KINASE RECEPTOR transmembrane signaling receptor activity#GO:0004888;protein kinase activity#GO:0004672;molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;protein tyrosine kinase activity#GO:0004713;catalytic activity#GO:0003824;transferase activity#GO:0016740;transmembrane receptor protein kinase activity#GO:0019199;signaling receptor activity#GO:0038023;catalytic activity, acting on a protein#GO:0140096 signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;regulation of neuron differentiation#GO:0045664;regulation of cell differentiation#GO:0045595;cell surface receptor signaling pathway#GO:0007166;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;signaling#GO:0023052;regulation of developmental process#GO:0050793;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;enzyme-linked receptor protein signaling pathway#GO:0007167 membrane#GO:0016020;signaling receptor complex#GO:0043235;cell periphery#GO:0071944;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=16523|UniProtKB=Q9H0T7 Q9H0T7 RAB17 PTHR24073:SF912 DRAB5-RELATED RAS-RELATED PROTEIN RAB-17 hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817 intracellular protein localization#GO:0008104;protein transport#GO:0015031;localization#GO:0051179;import into cell#GO:0098657;cellular localization#GO:0051641;establishment of localization#GO:0051234;transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;endocytosis#GO:0006897;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;macromolecule localization#GO:0033036 vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;endocytic vesicle#GO:0030139;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;cell periphery#GO:0071944;membrane#GO:0016020;cytoplasm#GO:0005737;plasma membrane#GO:0005886;endomembrane system#GO:0012505 G-protein#PC00020;small GTPase#PC00208 HUMAN|HGNC=20664|UniProtKB=Q71UI9 Q71UI9 H2AZ2 PTHR23430:SF280 HISTONE H2A HISTONE H2A.V structural molecule activity#GO:0005198 cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;negative regulation of gene expression, epigenetic#GO:0045814;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;cellular component assembly#GO:0022607;negative regulation of biosynthetic process#GO:0009890;chromatin organization#GO:0006325;biological regulation#GO:0065007;heterochromatin organization#GO:0070828;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;epigenetic regulation of gene expression#GO:0040029;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;heterochromatin formation#GO:0031507 nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;nucleosome#GO:0000786;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-DNA complex#GO:0032993;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=19399|UniProtKB=Q6P3X8 Q6P3X8 PGBD2 PTHR47055:SF2 DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 2-RELATED nucleic acid binding#GO:0003676;binding#GO:0005488;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677 HUMAN|HGNC=26048|UniProtKB=Q75QN2 Q75QN2 INTS8 PTHR13350:SF1 INTEGRATOR COMPLEX SUBUNIT 8 INTEGRATOR COMPLEX SUBUNIT 8 nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;snRNA metabolic process#GO:0016073;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;snRNA 3'-end processing#GO:0034472;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;snRNA processing#GO:0016180;RNA 3'-end processing#GO:0031123;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467 nucleus#GO:0005634;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;integrator complex#GO:0032039;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=462|UniProtKB=Q99218 Q99218 AMELY PTHR46794:SF6 AMELOGENIN, Y ISOFORM AMELOGENIN, Y ISOFORM structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 odontogenesis#GO:0042476;tissue development#GO:0009888;animal organ morphogenesis#GO:0009887;odontogenesis of dentin-containing tooth#GO:0042475;amelogenesis#GO:0097186;anatomical structure morphogenesis#GO:0009653;anatomical structure formation involved in morphogenesis#GO:0048646;animal organ development#GO:0048513;anatomical structure development#GO:0048856;developmental process#GO:0032502;biomineral tissue development#GO:0031214;animal gross anatomical part developmental process#GO:0160108;enamel mineralization#GO:0070166 extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical structure#GO:0110165 HUMAN|HGNC=6555|UniProtKB=O95214 O95214 LEPROTL1 PTHR12050:SF4 LEPTIN RECEPTOR-RELATED LEPTIN RECEPTOR OVERLAPPING TRANSCRIPT-LIKE 1 localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;endosomal transport#GO:0016197;intracellular transport#GO:0046907;transport#GO:0006810;vesicle-mediated transport#GO:0016192;cytosolic transport#GO:0016482;retrograde transport, endosome to Golgi#GO:0042147;establishment of localization in cell#GO:0051649;cellular process#GO:0009987 bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane#GO:0016020;vesicle membrane#GO:0012506;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;endosome membrane#GO:0010008;endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 transmembrane signal receptor#PC00197 HUMAN|HGNC=22980|UniProtKB=Q96EP9 Q96EP9 SLC10A4 PTHR10361:SF41 SODIUM-BILE ACID COTRANSPORTER SODIUM_BILE ACID COTRANSPORTER 4-RELATED secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;solute:monoatomic cation symporter activity#GO:0015294;monoatomic ion transmembrane transporter activity#GO:0015075;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;symporter activity#GO:0015293;carboxylic acid transmembrane transporter activity#GO:0046943;solute:sodium symporter activity#GO:0015370;monoatomic cation transmembrane transporter activity#GO:0008324;bile acid transmembrane transporter activity#GO:0015125 monocarboxylic acid transport#GO:0015718;organic hydroxy compound transport#GO:0015850;establishment of localization#GO:0051234;localization#GO:0051179;carboxylic acid transport#GO:0046942;transport#GO:0006810;organic acid transport#GO:0015849;bile acid and bile salt transport#GO:0015721;lipid localization#GO:0010876;lipid transport#GO:0006869;macromolecule localization#GO:0033036 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 primary active transporter#PC00068 HUMAN|HGNC=9870|UniProtKB=P54136 P54136 RARS1 PTHR11956:SF5 ARGINYL-TRNA SYNTHETASE ARGININE--TRNA LIGASE, CYTOPLASMIC catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;ligase activity#GO:0016874 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;translation#GO:0006412;metabolic process#GO:0008152;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 aminoacyl-tRNA synthetase#PC00047 HUMAN|HGNC=3968|UniProtKB=Q92674 Q92674 CENPI PTHR48208:SF2 CENTROMERE PROTEIN I CENTROMERE PROTEIN I organelle organization#GO:0006996;mitotic sister chromatid segregation#GO:0000070;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cellular component assembly#GO:0022607;chromatin organization#GO:0006325;chromosome segregation#GO:0007059;cellular component organization or biogenesis#GO:0071840;mitotic cell cycle process#GO:1903047;chromosome organization#GO:0051276;protein-containing complex organization#GO:0043933;cell cycle#GO:0007049;nuclear chromosome segregation#GO:0098813;membraneless organelle assembly#GO:0140694;sister chromatid segregation#GO:0000819;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;cell cycle process#GO:0022402;mitotic nuclear division#GO:0140014;mitotic cell cycle#GO:0000278;organelle assembly#GO:0070925;nuclear division#GO:0000280;kinetochore assembly#GO:0051382;kinetochore organization#GO:0051383;organelle fission#GO:0048285 intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;supramolecular complex#GO:0099080;organelle#GO:0043226;kinetochore#GO:0000776;chromosome#GO:0005694;condensed chromosome, centromeric region#GO:0000779;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;chromosome, centromeric region#GO:0000775;condensed chromosome#GO:0000793 HUMAN|HGNC=30499|UniProtKB=Q6NSJ2 Q6NSJ2 PHLDB3 PTHR12156:SF22 PLECKSTRIN HOMOLOGY-LIKE DOMAIN, FAMILY B, MEMBER 3 PLECKSTRIN HOMOLOGY-LIKE DOMAIN FAMILY B MEMBER 3 HUMAN|HGNC=29623|UniProtKB=Q9Y2E5 Q9Y2E5 MAN2B2 PTHR11607:SF28 ALPHA-MANNOSIDASE EPIDIDYMIS-SPECIFIC ALPHA-MANNOSIDASE hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798 lytic vacuole#GO:0000323;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;vacuole#GO:0005773;lysosome#GO:0005764 glycosidase#PC00110;hydrolase#PC00121 HUMAN|HGNC=4691|UniProtKB=P51841 P51841 GUCY2F PTHR11920:SF349 GUANYLYL CYCLASE RETINAL GUANYLYL CYCLASE 2 catalytic activity#GO:0003824;phosphorus-oxygen lyase activity#GO:0016849;cyclase activity#GO:0009975;peptide receptor activity#GO:0001653;guanylate cyclase activity#GO:0004383;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;lyase activity#GO:0016829 organophosphate biosynthetic process#GO:0090407;enzyme-linked receptor protein signaling pathway#GO:0007167;cGMP biosynthetic process#GO:0006182;cell communication#GO:0007154;sensory perception#GO:0007600;regulation of cellular process#GO:0050794;visual perception#GO:0007601;nucleoside phosphate metabolic process#GO:0006753;primary metabolic process#GO:0044238;sensory perception of light stimulus#GO:0050953;cellular response to stimulus#GO:0051716;nucleoside phosphate biosynthetic process#GO:1901293;system process#GO:0003008;cyclic nucleotide metabolic process#GO:0009187;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;cGMP metabolic process#GO:0046068;carbohydrate derivative metabolic process#GO:1901135;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide biosynthetic process#GO:0009165;ribonucleotide metabolic process#GO:0009259;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;nervous system process#GO:0050877;cyclic nucleotide biosynthetic process#GO:0009190;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;signaling#GO:0023052;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521;regulation of biological process#GO:0050789;purine nucleotide metabolic process#GO:0006163;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;cell surface receptor signaling pathway#GO:0007166;cyclic purine nucleotide metabolic process#GO:0052652;ribose phosphate biosynthetic process#GO:0046390;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;receptor guanylyl cyclase signaling pathway#GO:0007168;signal transduction#GO:0007165 non-motile cilium#GO:0097730;membrane-bounded organelle#GO:0043227;cilium#GO:0005929;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;organelle#GO:0043226;photoreceptor outer segment#GO:0001750;cell periphery#GO:0071944;photoreceptor cell cilium#GO:0097733;neuron projection#GO:0043005;membrane#GO:0016020;9+0 non-motile cilium#GO:0097731 guanylate cyclase#PC00114;lyase#PC00144 HUMAN|HGNC=18270|UniProtKB=Q5VTY9 Q5VTY9 HHAT PTHR13285:SF20 ACYLTRANSFERASE PROTEIN-CYSTEINE N-PALMITOYLTRANSFERASE HHAT palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740 cellular process#GO:0009987;primary metabolic process#GO:0044238;protein modification process#GO:0036211;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 acyltransferase#PC00042 HUMAN|HGNC=14857|UniProtKB=Q9UP83 Q9UP83 COG5 PTHR13228:SF3 CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 5 CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 5 Golgi vesicle transport#GO:0048193;transport#GO:0006810;intra-Golgi vesicle-mediated transport#GO:0006891;cellular process#GO:0009987;localization#GO:0051179;vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;vesicle tethering complex#GO:0099023;COG complex#GO:0017119;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794 HUMAN|HGNC=14158|UniProtKB=Q9BSN7 Q9BSN7 TMEM204 PTHR14627:SF0 TRANSMEMBRANE PROTEIN 204 TRANSMEMBRANE PROTEIN 204 regulation of cell communication#GO:0010646;regulation of cellular response to growth factor stimulus#GO:0090287;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 HUMAN|HGNC=37282|UniProtKB=Q9C0K3 Q9C0K3 ACTR3C PTHR11937:SF600 ACTIN ACTIN-RELATED PROTEIN 3C protein-containing complex binding#GO:0044877;protein binding#GO:0005515;actin binding#GO:0003779;actin filament binding#GO:0051015;structural constituent of cytoskeleton#GO:0005200;binding#GO:0005488;structural molecule activity#GO:0005198;cytoskeletal protein binding#GO:0008092 actin filament-based process#GO:0030029;cortical cytoskeleton organization#GO:0030865;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cortical actin cytoskeleton organization#GO:0030866;cellular component organization or biogenesis#GO:0071840;Arp2/3 complex-mediated actin nucleation#GO:0034314;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;actin nucleation#GO:0045010 actin cytoskeleton#GO:0015629;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;Arp2/3 protein complex#GO:0005885;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 actin and actin related protein#PC00039 HUMAN|HGNC=4727|UniProtKB=Q99878 Q99878 H2AC14 PTHR23430:SF378 HISTONE H2A HISTONE H2A TYPE 1-J structural molecule activity#GO:0005198 regulation of gene expression#GO:0010468;negative regulation of gene expression, epigenetic#GO:0045814;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;negative regulation of cellular process#GO:0048523;heterochromatin organization#GO:0070828;negative regulation of biosynthetic process#GO:0009890;chromatin organization#GO:0006325;biological regulation#GO:0065007;cellular component assembly#GO:0022607;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;epigenetic regulation of gene expression#GO:0040029;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;heterochromatin formation#GO:0031507;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519 chromosome#GO:0005694;nucleus#GO:0005634;chromatin#GO:0000785;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;protein-DNA complex#GO:0032993;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;nucleosome#GO:0000786;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=17688|UniProtKB=P78346 P78346 RPP30 PTHR13031:SF0 RIBONUCLEASE P SUBUNIT P30 RIBONUCLEASE P PROTEIN SUBUNIT P30 binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;endonuclease complex#GO:1905348;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoribonuclease complex#GO:1902555;ribonuclease P complex#GO:0030677;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;multimeric ribonuclease P complex#GO:0030681;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nucleolar ribonuclease P complex#GO:0005655;organelle lumen#GO:0043233 RNA metabolism protein#PC00031;endoribonuclease#PC00094 HUMAN|HGNC=28217|UniProtKB=Q969S6 Q969S6 TMEM203 PTHR13568:SF9 FAM11A, B PROTEIN TRANSMEMBRANE PROTEIN 203 calcium ion homeostasis#GO:0055074;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;inorganic ion homeostasis#GO:0098771;chemical homeostasis#GO:0048878;cellular homeostasis#GO:0019725;intracellular calcium ion homeostasis#GO:0006874;intracellular chemical homeostasis#GO:0055082;monoatomic ion homeostasis#GO:0050801;intracellular monoatomic ion homeostasis#GO:0006873;homeostatic process#GO:0042592 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=18609|UniProtKB=Q8NA42 Q8NA42 ZNF383 PTHR24390:SF260 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 383-RELATED sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=16290|UniProtKB=Q9UPN9 Q9UPN9 TRIM33 PTHR45915:SF3 TRANSCRIPTION INTERMEDIARY FACTOR E3 UBIQUITIN-PROTEIN LIGASE TRIM33 ubiquitin-like protein transferase activity#GO:0019787;transcription regulator activity#GO:0140110;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;transcription coregulator activity#GO:0003712;transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 chromosome#GO:0005694;nucleus#GO:0005634;chromatin#GO:0000785;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=26656|UniProtKB=Q8IWD5 Q8IWD5 MFSD6L PTHR16172:SF41 MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE cellular anatomical structure#GO:0110165;membrane#GO:0016020 HUMAN|HGNC=4105|UniProtKB=P0CL82 P0CL82 GAGE12I PTHR14047:SF30 P ANTIGEN FAMILY MEMBER 5-RELATED G ANTIGEN 1-RELATED HUMAN|HGNC=18381|UniProtKB=Q8IV01 Q8IV01 SYT12 PTHR10024:SF252 SYNAPTOTAGMIN SYNAPTOTAGMIN-12 molecular sensor activity#GO:0140299;lipid binding#GO:0008289;molecular function regulator activity#GO:0098772;protein binding#GO:0005515;binding#GO:0005488;phospholipid binding#GO:0005543;SNARE binding#GO:0000149 cellular process#GO:0009987;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;regulation of cellular process#GO:0050794;vesicle-mediated transport#GO:0016192;biological regulation#GO:0065007;transport#GO:0006810;establishment of localization#GO:0051234;regulation of secretion#GO:0051046;localization#GO:0051179;regulation of secretion by cell#GO:1903530;regulation of exocytosis#GO:0017157;regulation of localization#GO:0032879;regulation of transport#GO:0051049 intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;endomembrane system#GO:0012505;transport vesicle#GO:0030133;cytoplasm#GO:0005737;plasma membrane#GO:0005886;secretory vesicle#GO:0099503;membrane#GO:0016020;cell periphery#GO:0071944 membrane trafficking regulatory protein#PC00151 Synaptic vesicle trafficking#P05734>Synaptotagmin#P05769 HUMAN|HGNC=9817|UniProtKB=Q06609 Q06609 RAD51 PTHR22942:SF39 RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER DNA REPAIR PROTEIN RAD51 HOMOLOG 1 catalytic activity, acting on DNA#GO:0140097;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;double-stranded DNA binding#GO:0003690;ATP-dependent activity, acting on DNA#GO:0008094;DNA binding#GO:0003677;ATP-dependent activity#GO:0140657;single-stranded DNA binding#GO:0003697;binding#GO:0005488;nucleic acid binding#GO:0003676 organelle fission#GO:0048285;sexual reproduction#GO:0019953;mitotic recombination#GO:0006312;recombinational repair#GO:0000725;meiosis I cell cycle process#GO:0061982;reproductive process#GO:0022414;homologous recombination#GO:0035825;cellular response to stimulus#GO:0051716;reciprocal homologous recombination#GO:0140527;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cell cycle#GO:0007049;chromosome organization#GO:0051276;meiotic nuclear division#GO:0140013;macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;DNA repair#GO:0006281;nucleobase-containing compound metabolic process#GO:0006139;reciprocal meiotic recombination#GO:0007131;cellular response to stress#GO:0033554;nuclear division#GO:0000280;response to stimulus#GO:0050896;double-strand break repair via homologous recombination#GO:0000724;cell cycle process#GO:0022402;protein-containing complex assembly#GO:0065003;meiosis I#GO:0007127;cellular component organization#GO:0016043;meiotic cell cycle process#GO:1903046;double-strand break repair#GO:0006302;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;protein-DNA complex organization#GO:0071824;DNA recombination#GO:0006310;DNA metabolic process#GO:0006259;chromosome organization involved in meiotic cell cycle#GO:0070192;meiotic cell cycle#GO:0051321;metabolic process#GO:0008152;protein-DNA complex assembly#GO:0065004;cellular component assembly#GO:0022607;cellular process#GO:0009987;response to stress#GO:0006950;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085 intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membraneless organelle#GO:0043228;condensed nuclear chromosome#GO:0000794;condensed chromosome#GO:0000793;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;chromosome#GO:0005694;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 DNA metabolism protein#PC00009 HUMAN|HGNC=5163|UniProtKB=Q92902 Q92902 HPS1 PTHR12761:SF1 HERMANSKY-PUDLAK SYNDROME PROTEIN 1 BLOC-3 COMPLEX MEMBER HPS1 molecular function regulator activity#GO:0098772;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;guanyl-nucleotide exchange factor activity#GO:0005085 vesicle organization#GO:0016050;cellular component organization or biogenesis#GO:0071840;pigmentation#GO:0043473;melanosome organization#GO:0032438;organelle assembly#GO:0070925;cellular pigmentation#GO:0033059;cellular component assembly#GO:0022607;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular component organization#GO:0016043 protein-containing complex#GO:0032991;intracellular protein-containing complex#GO:0140535 HUMAN|HGNC=2036|UniProtKB=P56746 P56746 CLDN15 PTHR12002:SF74 CLAUDIN CLAUDIN-15 transporter activity#GO:0005215;paracellular tight junction channel activity#GO:0160187 establishment of localization#GO:0051234;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;paracellular transport#GO:0160184;transport#GO:0006810;cell-cell junction assembly#GO:0007043;cell-cell junction organization#GO:0045216;cell junction organization#GO:0034330;cellular component assembly#GO:0022607;cellular process#GO:0009987;cellular component organization#GO:0016043;cell junction assembly#GO:0034329;cellular component biogenesis#GO:0044085 apical junction complex#GO:0043296;anchoring junction#GO:0070161;cell junction#GO:0030054;tight junction#GO:0070160;cell periphery#GO:0071944;cell-cell junction#GO:0005911;membrane#GO:0016020;plasma membrane#GO:0005886;bicellular tight junction#GO:0005923;cellular anatomical structure#GO:0110165 tight junction#PC00214;cell junction protein#PC00070 HUMAN|HGNC=24287|UniProtKB=Q7LBR1 Q7LBR1 CHMP1B PTHR10476:SF18 CHARGED MULTIVESICULAR BODY PROTEIN CHARGED MULTIVESICULAR BODY PROTEIN 1B localization#GO:0051179;cellular localization#GO:0051641;protein transport#GO:0015031;late endosome to vacuole transport#GO:0045324;intracellular transport#GO:0046907;vacuolar transport#GO:0007034;transport#GO:0006810;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;endosomal transport#GO:0016197;macromolecule localization#GO:0033036;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;multivesicular body sorting pathway#GO:0071985;endosome transport via multivesicular body sorting pathway#GO:0032509;vesicle-mediated transport#GO:0016192 intracellular organelle#GO:0043229;endosome#GO:0005768;endosome membrane#GO:0010008;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;membrane#GO:0016020;protein-containing complex#GO:0032991;late endosome#GO:0005770;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;cytoplasm#GO:0005737 membrane traffic protein#PC00150 HUMAN|HGNC=16783|UniProtKB=Q6P1J9 Q6P1J9 CDC73 PTHR12466:SF8 CDC73 DOMAIN PROTEIN PARAFIBROMIN binding#GO:0005488;RNA polymerase binding#GO:0070063;enzyme binding#GO:0019899;protein binding#GO:0005515;RNA polymerase II complex binding#GO:0000993;RNA polymerase core enzyme binding#GO:0043175 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA metabolic process#GO:0051252;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;regulation of transcription elongation by RNA polymerase II#GO:0034243;regulation of DNA-templated transcription elongation#GO:0032784;positive regulation of RNA metabolic process#GO:0051254;positive regulation of DNA-templated transcription, elongation#GO:0032786;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789 intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234;Cdc73/Paf1 complex#GO:0016593;protein-containing complex#GO:0032991;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;membrane-enclosed lumen#GO:0031974;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;RNA polymerase II, holoenzyme#GO:0016591;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular membrane-bounded organelle#GO:0043231;transcription elongation factor complex#GO:0008023;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233 HUMAN|HGNC=34489|UniProtKB=A8K5M9 A8K5M9 C15orf62 PTHR15344:SF8 CDC42 EFFECTOR PROTEIN BORG SIMILAR TO HUMAN CHROMOSOME 15 OPEN READING FRAME 62 protein binding#GO:0005515;small GTPase binding#GO:0031267;enzyme binding#GO:0019899;binding#GO:0005488 positive regulation of cellular component biogenesis#GO:0044089;intracellular signaling cassette#GO:0141124;regulation of actin cytoskeleton organization#GO:0032956;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;regulation of anatomical structure morphogenesis#GO:0022603;regulation of anatomical structure size#GO:0090066;response to stimulus#GO:0050896;regulation of plasma membrane bounded cell projection assembly#GO:0120032;regulation of cellular component organization#GO:0051128;signaling#GO:0023052;regulation of cellular component biogenesis#GO:0044087;cellular component organization#GO:0016043;regulation of protein-containing complex assembly#GO:0043254;regulation of cellular component size#GO:0032535;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;regulation of cell shape#GO:0008360;positive regulation of organelle organization#GO:0010638;Rho protein signal transduction#GO:0007266;regulation of biological quality#GO:0065008;regulation of actin filament length#GO:0030832;positive regulation of cellular component organization#GO:0051130;regulation of actin filament polymerization#GO:0030833;positive regulation of protein polymerization#GO:0032273;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;regulation of actin polymerization or depolymerization#GO:0008064;positive regulation of cellular process#GO:0048522;regulation of actin filament organization#GO:0110053;regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of cell projection organization#GO:0031344;regulation of actin filament-based process#GO:0032970;regulation of protein polymerization#GO:0032271;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794;regulation of developmental process#GO:0050793;regulation of supramolecular fiber organization#GO:1902903;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of cell projection assembly#GO:0060491;positive regulation of cell projection organization#GO:0031346 cytoplasm#GO:0005737;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cell periphery#GO:0071944;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 scaffold/adaptor protein#PC00226 HUMAN|HGNC=24246|UniProtKB=Q8N9B8 Q8N9B8 RASGEF1A PTHR23113:SF172 GUANINE NUCLEOTIDE EXCHANGE FACTOR RAS-GEF DOMAIN-CONTAINING FAMILY MEMBER 1A guanyl-nucleotide exchange factor activity#GO:0005085;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124;Ras protein signal transduction#GO:0007265;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=31855|UniProtKB=Q5JQD4 Q5JQD4 PYY3 PTHR10533:SF14 NEUROPEPTIDE Y/PANCREATIC HORMONE/PEPTIDE YY PEPTIDE YY-RELATED G protein-coupled receptor binding#GO:0001664;signaling receptor regulator activity#GO:0030545;neuropeptide receptor binding#GO:0071855;receptor ligand activity#GO:0048018;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;neuropeptide hormone activity#GO:0005184;signaling receptor binding#GO:0005102;binding#GO:0005488;hormone activity#GO:0005179;molecular function activator activity#GO:0140677;protein binding#GO:0005515 biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;multicellular organismal process#GO:0032501;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;neuropeptide signaling pathway#GO:0007218;cell communication#GO:0007154;feeding behavior#GO:0007631;G protein-coupled receptor signaling pathway#GO:0007186 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HUMAN|HGNC=9862|UniProtKB=P61225 P61225 RAP2B PTHR24070:SF194 RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY RAS-RELATED PROTEIN RAP-2B ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818 cell communication#GO:0007154;regulation of cell motility#GO:2000145;intracellular signal transduction#GO:0035556;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;negative regulation of biological process#GO:0048519;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;negative regulation of cellular process#GO:0048523;negative regulation of cell migration#GO:0030336;regulation of cell migration#GO:0030334;regulation of locomotion#GO:0040012;intracellular signaling cassette#GO:0141124;negative regulation of locomotion#GO:0040013;negative regulation of cell motility#GO:2000146;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;cellular process#GO:0009987;signal transduction#GO:0007165 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 small GTPase#PC00208 Integrin signalling pathway#P00034>Rap1#P00906 HUMAN|HGNC=14663|UniProtKB=A6NGJ6 A6NGJ6 TRIM64 PTHR24103:SF716 E3 UBIQUITIN-PROTEIN LIGASE TRIM TRIPARTITE MOTIF-CONTAINING PROTEIN 64-RELATED ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824 response to other organism#GO:0051707;biological regulation#GO:0065007;defense response to other organism#GO:0098542;defense response to symbiont#GO:0140546;immune response#GO:0006955;response to stress#GO:0006950;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;response to biotic stimulus#GO:0009607;regulation of gene expression#GO:0010468;defense response#GO:0006952;response to external stimulus#GO:0009605;innate immune response#GO:0045087;regulation of biosynthetic process#GO:0009889;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;immune system process#GO:0002376 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=5994|UniProtKB=P27930 P27930 IL1R2 PTHR11890:SF3 INTERLEUKIN-1 RECEPTOR FAMILY MEMBER INTERLEUKIN-1 RECEPTOR TYPE 2 molecular transducer activity#GO:0060089;immune receptor activity#GO:0140375;signaling receptor activity#GO:0038023;cytokine receptor activity#GO:0004896;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell surface#GO:0009986 transmembrane signal receptor#PC00197 HUMAN|HGNC=25486|UniProtKB=Q6NSI4 Q6NSI4 RADX PTHR14944:SF2 RPA-RELATED PROTEIN RADX RPA-RELATED PROTEIN RADX HUMAN|HGNC=24174|UniProtKB=Q5FVE4 Q5FVE4 ACSBG2 PTHR24096:SF260 LONG-CHAIN-FATTY-ACID--COA LIGASE LONG-CHAIN-FATTY-ACID--COA LIGASE ACSBG2 ligase activity#GO:0016874;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;ligase activity, forming carbon-sulfur bonds#GO:0016877 fatty acid biosynthetic process#GO:0006633;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;cellular process#GO:0009987;long-chain fatty acid metabolic process#GO:0001676;monocarboxylic acid biosynthetic process#GO:0072330;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;small molecule metabolic process#GO:0044281;carboxylic acid biosynthetic process#GO:0046394;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;oxoacid metabolic process#GO:0043436 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 ligase#PC00142 HUMAN|HGNC=9238|UniProtKB=Q06203 Q06203 PPAT PTHR11907:SF20 AMIDOPHOSPHORIBOSYLTRANSFERASE AMIDOPHOSPHORIBOSYLTRANSFERASE glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;transferase activity#GO:0016740;pentosyltransferase activity#GO:0016763 purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;nucleotide biosynthetic process#GO:0009165;nucleotide metabolic process#GO:0009117;organophosphate biosynthetic process#GO:0090407;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleobase-containing small molecule metabolic process#GO:0055086;nucleoside phosphate biosynthetic process#GO:1901293 metabolite interconversion enzyme#PC00262;transferase#PC00220 De novo purine biosynthesis#P02738>Amidophosphoribosyl transferase#P02905 HUMAN|HGNC=16686|UniProtKB=Q7Z7F7 Q7Z7F7 MRPL55 PTHR34095:SF1 39S RIBOSOMAL PROTEIN L55, MITOCHONDRIAL LARGE RIBOSOMAL SUBUNIT PROTEIN ML55 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 translation#GO:0006412;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein biosynthetic process#GO:0160307 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organellar ribosome#GO:0000313;mitochondrial ribosome#GO:0005761;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;mitochondrion#GO:0005739;ribosome#GO:0005840;membraneless organelle#GO:0043228;mitochondrial large ribosomal subunit#GO:0005762;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;membrane-enclosed lumen#GO:0031974 ribosomal protein#PC00202 HUMAN|HGNC=25513|UniProtKB=Q9H9Y4 Q9H9Y4 GPN2 PTHR21231:SF3 XPA-BINDING PROTEIN 1-RELATED GPN-LOOP GTPASE 2 hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protein-binding activity modulator#PC00095;G-protein#PC00020;small GTPase#PC00208 HUMAN|HGNC=23429|UniProtKB=Q5JSS6 Q5JSS6 MEIG1 PTHR17008:SF1 MEIOSIS-EXPRESSED GENE 1 PROTEIN MEIOSIS EXPRESSED GENE 1 PROTEIN HOMOLOG cellular developmental process#GO:0048869;sperm axoneme assembly#GO:0007288;plasma membrane bounded cell projection assembly#GO:0120031;flagellated sperm motility#GO:0030317;spermatogenesis#GO:0007283;developmental process#GO:0032502;male gamete generation#GO:0048232;plasma membrane bounded cell projection organization#GO:0120036;microtubule cytoskeleton organization#GO:0000226;anatomical structure development#GO:0048856;multicellular organismal reproductive process#GO:0048609;axoneme assembly#GO:0035082;organelle assembly#GO:0070925;microtubule bundle formation#GO:0001578;spermatid development#GO:0007286;sexual reproduction#GO:0019953;cell motility#GO:0048870;microtubule-based movement#GO:0007018;reproductive process#GO:0022414;developmental process involved in reproduction#GO:0003006;germ cell development#GO:0007281;cellular component organization or biogenesis#GO:0071840;motile cilium assembly#GO:0044458;microtubule-based process#GO:0007017;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;cilium movement involved in cell motility#GO:0060294;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cell projection assembly#GO:0030031;cilium-dependent cell motility#GO:0060285;sperm flagellum assembly#GO:0120316;cilium organization#GO:0044782;spermatid differentiation#GO:0048515;cilium or flagellum-dependent cell motility#GO:0001539;cilium movement#GO:0003341;gamete generation#GO:0007276;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cellular process involved in reproduction in multicellular organism#GO:0022412;cell development#GO:0048468;cellular component organization#GO:0016043;cilium assembly#GO:0060271;sperm motility#GO:0097722 nucleus#GO:0005634;cytosol#GO:0005829;microtubule cytoskeleton#GO:0015630;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228 HUMAN|HGNC=8822|UniProtKB=Q15121 Q15121 PEA15 PTHR48169:SF1 DED DOMAIN-CONTAINING PROTEIN ASTROCYTIC PHOSPHOPROTEIN PEA-15 negative regulation of cell communication#GO:0010648;regulation of apoptotic signaling pathway#GO:2001233;regulation of signaling#GO:0023051;negative regulation of apoptotic signaling pathway#GO:2001234;negative regulation of signaling#GO:0023057;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of extrinsic apoptotic signaling pathway#GO:2001236;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;regulation of response to stimulus#GO:0048583;regulation of apoptotic process#GO:0042981;negative regulation of cellular process#GO:0048523;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of response to stimulus#GO:0048585;negative regulation of apoptotic process#GO:0043066;negative regulation of extrinsic apoptotic signaling pathway#GO:2001237;negative regulation of programmed cell death#GO:0043069 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 Gonadotropin-releasing hormone receptor pathway#P06664>PEA-15#P06853 HUMAN|HGNC=10061|UniProtKB=Q99496 Q99496 RNF2 PTHR46076:SF4 E3 UBIQUITIN-PROTEIN LIGASE RING1 / RING 2 FAMILY MEMBER E3 UBIQUITIN-PROTEIN LIGASE RING2 catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;binding#GO:0005488;acyltransferase activity#GO:0016746;chromatin binding#GO:0003682;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787 transferase complex#GO:1990234;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;ubiquitin ligase complex#GO:0000151;nucleus#GO:0005634;PcG protein complex#GO:0031519;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=24805|UniProtKB=Q86X60 Q86X60 FAM72B PTHR31841:SF1 PROTEIN FAM72A-RELATED PROTEIN FAM72A-RELATED cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=28462|UniProtKB=Q9H6F2 Q9H6F2 TMEM38A PTHR12454:SF3 TRIMERIC INTRACELLULAR CATION CHANNEL TRIMERIC INTRACELLULAR CATION CHANNEL TYPE A metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic cation channel activity#GO:0005261;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;potassium channel activity#GO:0005267 transport#GO:0006810;establishment of localization#GO:0051234;calcium ion transmembrane import into cytosol#GO:0097553;calcium ion transport#GO:0006816;release of sequestered calcium ion into cytosol#GO:0051209;cellular process#GO:0009987;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;release of sequestered calcium ion into cytosol by sarcoplasmic reticulum#GO:0014808;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;calcium ion transmembrane transport#GO:0070588;metal ion transport#GO:0030001 sarcoplasmic reticulum#GO:0016529;membrane#GO:0016020;cytoplasm#GO:0005737;endomembrane system#GO:0012505;sarcoplasmic reticulum membrane#GO:0033017;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;sarcoplasm#GO:0016528;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622 ion channel#PC00133;transporter#PC00227 HUMAN|HGNC=26059|UniProtKB=Q9NWV4 Q9NWV4 CZIB PTHR12857:SF0 CXXC MOTIF CONTAINING ZINC BINDING PROTEIN CXXC MOTIF CONTAINING ZINC BINDING PROTEIN zinc ion binding#GO:0008270;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;transition metal ion binding#GO:0046914;metal ion binding#GO:0046872;cation binding#GO:0043169 HUMAN|HGNC=33164|UniProtKB=Q6NXT2 Q6NXT2 H3-5 PTHR11426:SF293 HISTONE H3 HISTONE H3.3C mitotic cell cycle#GO:0000278;sister chromatid segregation#GO:0000819;nuclear chromosome segregation#GO:0098813;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;cell cycle#GO:0007049;mitotic nuclear division#GO:0140014;cell cycle process#GO:0022402;mitotic metaphase chromosome alignment#GO:0007080;protein-containing complex assembly#GO:0065003;organelle fission#GO:0048285;localization#GO:0051179;kinetochore organization#GO:0051383;nuclear division#GO:0000280;organelle localization#GO:0051640;organelle assembly#GO:0070925;kinetochore assembly#GO:0051382;cellular component assembly#GO:0022607;chromosome localization#GO:0050000;mitotic sister chromatid segregation#GO:0000070;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;chromosome organization#GO:0051276;mitotic cell cycle process#GO:1903047;metaphase chromosome alignment#GO:0051310;chromosome segregation#GO:0007059 chromatin/chromatin-binding, or -regulatory protein#PC00077 DNA replication#P00017>Histones#P00527 HUMAN|HGNC=17871|UniProtKB=Q9NPI5 Q9NPI5 NMRK2 PTHR10285:SF143 URIDINE KINASE NICOTINAMIDE RIBOSIDE KINASE 2 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 kinase#PC00137;nucleotide kinase#PC00172 HUMAN|HGNC=26763|UniProtKB=Q2M3C6 Q2M3C6 TMEM266 PTHR46842:SF1 TRANSMEMBRANE PROTEIN 266 TRANSMEMBRANE PROTEIN 266 HUMAN|HGNC=24535|UniProtKB=Q9NV06 Q9NV06 DCAF13 PTHR22851:SF0 U3 SMALL NUCLEOLAR RNA U3 SNORNA ASSOCIATED PROTEIN DDB1- AND CUL4-ASSOCIATED FACTOR 13 macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;ribosomal small subunit biogenesis#GO:0042274;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;maturation of SSU-rRNA#GO:0030490;RNA processing#GO:0006396;biosynthetic process#GO:0009058;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;small-subunit processome#GO:0032040;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;preribosome#GO:0030684;ribonucleoprotein complex#GO:1990904;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 RNA metabolism protein#PC00031 HUMAN|HGNC=18297|UniProtKB=Q9UKJ0 Q9UKJ0 PILRB PTHR15549:SF26 PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR ALPHA-RELATED molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=13386|UniProtKB=Q8TDX7 Q8TDX7 NEK7 PTHR43289:SF2 MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 positive regulation of cellular component biogenesis#GO:0044089;regulation of response to external stimulus#GO:0032101;positive regulation of immune system process#GO:0002684;positive regulation of pattern recognition receptor signaling pathway#GO:0062208;positive regulation of biological process#GO:0048518;positive regulation of response to external stimulus#GO:0032103;regulation of cellular component organization#GO:0051128;regulation of cellular component biogenesis#GO:0044087;regulation of protein-containing complex assembly#GO:0043254;regulation of biological process#GO:0050789;positive regulation of signaling#GO:0023056;regulation of intracellular signal transduction#GO:1902531;positive regulation of cellular component organization#GO:0051130;regulation of signaling#GO:0023051;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of cellular process#GO:0048522;positive regulation of innate immune response#GO:0045089;regulation of innate immune response#GO:0045088;positive regulation of response to biotic stimulus#GO:0002833;regulation of response to stress#GO:0080134;positive regulation of defense response#GO:0031349;positive regulation of immune response#GO:0050778;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of immune system process#GO:0002682;regulation of response to biotic stimulus#GO:0002831;regulation of cell communication#GO:0010646;positive regulation of signal transduction#GO:0009967;regulation of immune response#GO:0050776;regulation of defense response#GO:0031347 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=31992|UniProtKB=Q6P3W6 Q6P3W6 NBPF10 PTHR14199:SF35 NEUROBLASTOMA BREAKPOINT FAMILY MEMBER 6-LIKE PROTEIN NBPF FAMILY MEMBER NBPF1-RELATED HUMAN|HGNC=37492|UniProtKB=A6NJY1 A6NJY1 SLC9B1P1 PTHR31102:SF5 FAMILY NOT NAMED SLC9B1-LIKE PROTEIN SLC9B1P1-RELATED transport#GO:0006810;cellular process#GO:0009987;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234 HUMAN|HGNC=25022|UniProtKB=Q9GZP4 Q9GZP4 PITHD1 PTHR12175:SF7 AD039 HT014 THIOREDOXIN FAMILY TRP26 PITH DOMAIN-CONTAINING PROTEIN 1 regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;regulation of cell development#GO:0060284;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of myeloid cell differentiation#GO:0045639;regulation of cell differentiation#GO:0045595;positive regulation of cell differentiation#GO:0045597;positive regulation of developmental process#GO:0051094;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of developmental process#GO:0050793;regulation of multicellular organismal development#GO:2000026;regulation of biological process#GO:0050789;regulation of hemopoiesis#GO:1903706;regulation of myeloid cell differentiation#GO:0045637 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 oxidoreductase#PC00176 HUMAN|HGNC=10874|UniProtKB=O15389 O15389 SIGLEC5 PTHR12035:SF125 SIALIC ACID BINDING IMMUNOGLOBULIN-LIKE LECTIN SIALIC ACID-BINDING IG-LIKE LECTIN 5 organic acid binding#GO:0043177;carbohydrate derivative binding#GO:0097367;ion binding#GO:0043167;binding#GO:0005488;carboxylic acid binding#GO:0031406;anion binding#GO:0043168;small molecule binding#GO:0036094 cellular process#GO:0009987;cell adhesion#GO:0007155 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 cell adhesion molecule#PC00069;immunoglobulin superfamily cell adhesion molecule#PC00125 HUMAN|HGNC=24220|UniProtKB=Q6P1N9 Q6P1N9 TATDN1 PTHR10060:SF15 TATD FAMILY DEOXYRIBONUCLEASE DEOXYRIBONUCLEASE TATDN1 exonuclease activity#GO:0004527;3'-5'-DNA exonuclease activity#GO:0008296;nuclease activity#GO:0004518;DNA exonuclease activity, producing 5'-phosphomonoesters#GO:0016895;hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;DNA nuclease activity#GO:0004536;DNA exonuclease activity#GO:0004529;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;3'-5' exonuclease activity#GO:0008408;catalytic activity, acting on DNA#GO:0140097 DNA metabolism protein#PC00009;endodeoxyribonuclease#PC00093 HUMAN|HGNC=8105|UniProtKB=P0CE72 P0CE72 OCM PTHR11653:SF16 PARVALBUMIN ALPHA ONCOMODULIN-1 ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;calcium ion binding#GO:0005509;metal ion binding#GO:0046872;cation binding#GO:0043169 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 calcium-binding protein#PC00060;calmodulin-related#PC00061 HUMAN|HGNC=6708|UniProtKB=P48449 P48449 LSS PTHR11764:SF94 TERPENE CYCLASE/MUTASE FAMILY MEMBER LANOSTEROL SYNTHASE isomerase activity#GO:0016853;catalytic activity#GO:0003824;intramolecular transferase activity#GO:0016866 small molecule metabolic process#GO:0044281;secondary alcohol metabolic process#GO:1902652;primary metabolic process#GO:0044238;sterol metabolic process#GO:0016125;steroid biosynthetic process#GO:0006694;secondary alcohol biosynthetic process#GO:1902653;alcohol metabolic process#GO:0006066;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;cholesterol metabolic process#GO:0008203;lipid biosynthetic process#GO:0008610;cholesterol biosynthetic process#GO:0006695;sterol biosynthetic process#GO:0016126;biosynthetic process#GO:0009058;steroid metabolic process#GO:0008202;cellular process#GO:0009987;alcohol biosynthetic process#GO:0046165 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;lipid droplet#GO:0005811;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228;cellular anatomical structure#GO:0110165;organelle#GO:0043226 cyclase#PC00079;lyase#PC00144 Cholesterol biosynthesis#P00014>Anosterol synthase#P00497 HUMAN|HGNC=23188|UniProtKB=Q7Z6K1 Q7Z6K1 THAP5 PTHR46927:SF1 AGAP005574-PA THAP DOMAIN-CONTAINING PROTEIN 5 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=7966|UniProtKB=Q13133 Q13133 NR1H3 PTHR24082:SF259 NUCLEAR HORMONE RECEPTOR OXYSTEROLS RECEPTOR LXR-ALPHA RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;nuclear receptor activity#GO:0004879;cis-regulatory region sequence-specific DNA binding#GO:0000987;molecular transducer activity#GO:0060089;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;signaling receptor activity#GO:0038023;sequence-specific DNA binding#GO:0043565 cellular process#GO:0009987;positive regulation of transport#GO:0051050;positive regulation of biological process#GO:0048518;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of response to external stimulus#GO:0032102;regulation of response to external stimulus#GO:0032101;positive regulation of macromolecule metabolic process#GO:0010604;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;chemical homeostasis#GO:0048878;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of localization#GO:0032879;regulation of transport#GO:0051049;regulation of biological process#GO:0050789;lipid homeostasis#GO:0055088;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;positive regulation of DNA-templated transcription#GO:0045893;negative regulation of response to stimulus#GO:0048585;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of response to stimulus#GO:0048583;developmental process#GO:0032502;regulation of response to stress#GO:0080134;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;cholesterol homeostasis#GO:0042632;positive regulation of RNA metabolic process#GO:0051254;homeostatic process#GO:0042592;negative regulation of inflammatory response#GO:0050728;regulation of cellular process#GO:0050794;negative regulation of defense response#GO:0031348;regulation of macromolecule metabolic process#GO:0060255;regulation of defense response#GO:0031347;regulation of inflammatory response#GO:0050727;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891 nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 C4 zinc finger nuclear receptor#PC00169 HUMAN|HGNC=7545|UniProtKB=P10242 P10242 MYB PTHR45614:SF5 MYB PROTEIN-RELATED TRANSCRIPTIONAL ACTIVATOR MYB sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;cell cycle#GO:0007049;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;mitotic cell cycle#GO:0000278;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 homeodomain transcription factor#PC00119 HUMAN|HGNC=24911|UniProtKB=Q96HH9 Q96HH9 GRAMD2B PTHR46645:SF2 GRAM DOMAIN-CONTAINING PROTEIN 2B-RELATED GRAM DOMAIN-CONTAINING PROTEIN 2B cytoplasmic microtubule#GO:0005881;microtubule cytoskeleton#GO:0015630;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;organelle#GO:0043226;supramolecular complex#GO:0099080;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;microtubule#GO:0005874 HUMAN|HGNC=14416|UniProtKB=Q9NXB9 Q9NXB9 ELOVL2 PTHR11157:SF16 FATTY ACID ACYL TRANSFERASE-RELATED VERY LONG CHAIN FATTY ACID ELONGASE 2 transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 monocarboxylic acid biosynthetic process#GO:0072330;sphingolipid biosynthetic process#GO:0030148;fatty acid metabolic process#GO:0006631;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;lipid biosynthetic process#GO:0008610;fatty acid biosynthetic process#GO:0006633;biosynthetic process#GO:0009058;cellular process#GO:0009987;oxoacid metabolic process#GO:0043436;small molecule metabolic process#GO:0044281;very long-chain fatty acid metabolic process#GO:0000038;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid biosynthetic process#GO:0046394 organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;membrane#GO:0016020 transferase#PC00220;acyltransferase#PC00042 HUMAN|HGNC=26458|UniProtKB=Q96N21 Q96N21 TEPSIN PTHR21514:SF0 AP-4 COMPLEX ACCESSORY SUBUNIT TEPSIN AP-4 COMPLEX ACCESSORY SUBUNIT TEPSIN Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;trans-Golgi network#GO:0005802;cellular anatomical structure#GO:0110165;trans-Golgi network membrane#GO:0032588;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=4266|UniProtKB=Q02643 Q02643 GHRHR PTHR45620:SF14 PDF RECEPTOR-LIKE PROTEIN-RELATED GROWTH HORMONE-RELEASING HORMONE RECEPTOR binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;growth factor binding#GO:0019838;molecular transducer activity#GO:0060089;protein binding#GO:0005515;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;signaling receptor activity#GO:0038023 biological regulation#GO:0065007;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of cellular process#GO:0048522;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;positive regulation of cell population proliferation#GO:0008284;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;G protein-coupled receptor signaling pathway#GO:0007186 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=7091|UniProtKB=Q29980 Q29980 MICB PTHR16675:SF154 MHC CLASS I-RELATED MHC CLASS I POLYPEPTIDE-RELATED SEQUENCE A-RELATED protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488;antigen binding#GO:0003823;peptide binding#GO:0042277 positive regulation of immune system process#GO:0002684;immune response#GO:0006955;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;positive regulation of response to stimulus#GO:0048584;lymphocyte activation#GO:0046649;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;positive regulation of immune effector process#GO:0002699;positive regulation of leukocyte mediated immunity#GO:0002705;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;leukocyte activation#GO:0045321;T cell activation#GO:0042110;regulation of leukocyte mediated immunity#GO:0002703;regulation of biological process#GO:0050789;positive regulation of adaptive immune response#GO:0002821;response to stimulus#GO:0050896;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;immune system process#GO:0002376;regulation of lymphocyte mediated immunity#GO:0002706;regulation of immune response#GO:0050776;regulation of cell killing#GO:0031341;cell activation#GO:0001775;positive regulation of lymphocyte mediated immunity#GO:0002708;regulation of immune effector process#GO:0002697;antigen processing and presentation#GO:0019882;regulation of leukocyte mediated cytotoxicity#GO:0001910 external side of plasma membrane#GO:0009897;extracellular region#GO:0005576;side of membrane#GO:0098552;membrane#GO:0016020;cell periphery#GO:0071944;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 major histocompatibility complex protein#PC00149;defense/immunity protein#PC00090 HUMAN|HGNC=26801|UniProtKB=Q8N8Q8 Q8N8Q8 COX18 PTHR12428:SF70 OXA1 CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX18, MITOCHONDRIAL molecular carrier activity#GO:0140104;protein carrier activity#GO:0140597;membrane insertase activity#GO:0032977 cytochrome complex assembly#GO:0017004;mitochondrial respiratory chain complex IV assembly#GO:0033617;protein-containing complex organization#GO:0043933;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;cellular component organization or biogenesis#GO:0071840;inner mitochondrial membrane organization#GO:0007007;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;mitochondrial membrane organization#GO:0007006;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;establishment of protein localization to membrane#GO:0090150;macromolecule localization#GO:0033036;mitochondrion organization#GO:0007005;membrane organization#GO:0061024;mitochondrial respiratory chain complex assembly#GO:0033108;cellular component assembly#GO:0022607;protein insertion into membrane#GO:0051205;localization within membrane#GO:0051668;respiratory chain complex IV assembly#GO:0008535;cellular localization#GO:0051641;localization#GO:0051179;protein localization to mitochondrion#GO:0070585;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;protein localization to organelle#GO:0033365 membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrial inner membrane#GO:0005743;organelle envelope#GO:0031967;membrane#GO:0016020 transporter#PC00227 HUMAN|HGNC=21257|UniProtKB=Q9Y530 Q9Y530 OARD1 PTHR12521:SF0 PROTEIN C6ORF130 ADP-RIBOSE GLYCOHYDROLASE OARD1 hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 metabolic process#GO:0008152;purine nucleoside metabolic process#GO:0042278;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;nucleobase-containing small molecule metabolic process#GO:0055086;primary metabolic process#GO:0044238;response to stress#GO:0006950;cellular response to stimulus#GO:0051716;purine-containing compound metabolic process#GO:0072521;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;nucleoside metabolic process#GO:0009116;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139 membraneless organelle#GO:0043228;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;site of DNA damage#GO:0090734;chromosome#GO:0005694;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654 HUMAN|HGNC=1804|UniProtKB=P31358 P31358 CD52 PTHR15029:SF0 CAMPATH-1 ANTIGEN CAMPATH-1 ANTIGEN positive regulation of cytosolic calcium ion concentration#GO:0007204;regulation of biological quality#GO:0065008;biological regulation#GO:0065007 cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;motile cilium#GO:0031514;sperm flagellum#GO:0036126;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;cilium#GO:0005929;9+2 motile cilium#GO:0097729 HUMAN|HGNC=14856|UniProtKB=Q9H342 Q9H342 OR51J1 PTHR26450:SF81 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 51J1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=14573|UniProtKB=Q9Y227 Q9Y227 ENTPD4 PTHR11782:SF29 ADENOSINE/GUANOSINE DIPHOSPHATASE ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 4 hydrolase activity#GO:0016787;nucleoside diphosphate phosphatase activity#GO:0017110;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817 metabolic process#GO:0008152;nucleotide catabolic process#GO:0009166;nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative metabolic process#GO:1901135;ribonucleotide catabolic process#GO:0009261;pyrimidine-containing compound metabolic process#GO:0072527;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;organophosphate metabolic process#GO:0019637;nucleobase-containing compound catabolic process#GO:0034655;nucleobase-containing compound metabolic process#GO:0006139;nucleoside diphosphate metabolic process#GO:0009132;ribonucleotide metabolic process#GO:0009259;nucleotide metabolic process#GO:0009117;ribonucleoside diphosphate catabolic process#GO:0009191;organophosphate catabolic process#GO:0046434;nucleoside diphosphate catabolic process#GO:0009134;ribonucleoside diphosphate metabolic process#GO:0009185;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;nucleoside triphosphate metabolic process#GO:0009141;nucleoside phosphate metabolic process#GO:0006753;carbohydrate derivative catabolic process#GO:1901136;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;nucleoside phosphate catabolic process#GO:1901292 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794 nucleotide phosphatase#PC00173;hydrolase#PC00121;phosphatase#PC00181 HUMAN|HGNC=25058|UniProtKB=Q6ZTW0 Q6ZTW0 TPGS1 PTHR31932:SF2 TUBULIN POLYGLUTAMYLASE COMPLEX SUBUNIT 1 TUBULIN POLYGLUTAMYLASE COMPLEX SUBUNIT 1 microtubule binding#GO:0008017;binding#GO:0005488;ligase activity, forming carbon-nitrogen bonds#GO:0016879;protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;ligase activity#GO:0016874;tubulin binding#GO:0015631;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 cellular component organization or biogenesis#GO:0071840;motile cilium assembly#GO:0044458;microtubule-based process#GO:0007017;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cilium movement involved in cell motility#GO:0060294;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;spermatid differentiation#GO:0048515;cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;sperm flagellum assembly#GO:0120316;cilium-dependent cell motility#GO:0060285;cilium organization#GO:0044782;cilium assembly#GO:0060271;cellular component organization#GO:0016043;sperm motility#GO:0097722;cell differentiation#GO:0030154;cell projection organization#GO:0030030;gamete generation#GO:0007276;cell development#GO:0048468;cellular process involved in reproduction in multicellular organism#GO:0022412;flagellated sperm motility#GO:0030317;plasma membrane bounded cell projection assembly#GO:0120031;spermatogenesis#GO:0007283;developmental process#GO:0032502;cellular developmental process#GO:0048869;sperm axoneme assembly#GO:0007288;male gamete generation#GO:0048232;plasma membrane bounded cell projection organization#GO:0120036;organelle assembly#GO:0070925;sexual reproduction#GO:0019953;spermatid development#GO:0007286;microtubule bundle formation#GO:0001578;microtubule cytoskeleton organization#GO:0000226;anatomical structure development#GO:0048856;axoneme assembly#GO:0035082;multicellular organismal reproductive process#GO:0048609;developmental process involved in reproduction#GO:0003006;germ cell development#GO:0007281;cell motility#GO:0048870;microtubule-based movement#GO:0007018;reproductive process#GO:0022414 cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;microtubule cytoskeleton#GO:0015630;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232 cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=31817|UniProtKB=Q5JNZ5 Q5JNZ5 RPS26P11 PTHR12538:SF7 40S RIBOSOMAL PROTEIN S26 SMALL RIBOSOMAL SUBUNIT PROTEIN ES26-RELATED mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198;RNA binding#GO:0003723 ribonucleoprotein complex#GO:1990904;cytosolic small ribosomal subunit#GO:0022627;small ribosomal subunit#GO:0015935;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;cytosolic ribosome#GO:0022626;ribosome#GO:0005840;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737 ribosomal protein#PC00202;translational protein#PC00263 HUMAN|HGNC=5583|UniProtKB=A0A0C4DH30 A0A0C4DH30 IGHV3-16 PTHR23266:SF372 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 3-23-RELATED binding#GO:0005488;antigen binding#GO:0003823 immune response#GO:0006955;response to stimulus#GO:0050896;adaptive immune response#GO:0002250;immune system process#GO:0002376;immune effector process#GO:0002252;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=29567|UniProtKB=Q96GR2 Q96GR2 ACSBG1 PTHR24096:SF296 LONG-CHAIN-FATTY-ACID--COA LIGASE LONG-CHAIN-FATTY-ACID--COA LIGASE ACSBG1 ATP-dependent activity#GO:0140657;ligase activity#GO:0016874;catalytic activity#GO:0003824;ligase activity, forming carbon-sulfur bonds#GO:0016877 carboxylic acid biosynthetic process#GO:0046394;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;monocarboxylic acid metabolic process#GO:0032787;small molecule metabolic process#GO:0044281;oxoacid metabolic process#GO:0043436;cellular process#GO:0009987;long-chain fatty acid metabolic process#GO:0001676;biosynthetic process#GO:0009058;fatty acid biosynthetic process#GO:0006633;lipid biosynthetic process#GO:0008610;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;monocarboxylic acid biosynthetic process#GO:0072330 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 ligase#PC00142 HUMAN|HGNC=7035|UniProtKB=P55083 P55083 MFAP4 PTHR19143:SF225 FIBRINOGEN/TENASCIN/ANGIOPOEITIN MICROFIBRIL-ASSOCIATED GLYCOPROTEIN 4 extracellular structure organization#GO:0043062;supramolecular fiber organization#GO:0097435;external encapsulating structure organization#GO:0045229;cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;cellular component assembly#GO:0022607;extracellular matrix assembly#GO:0085029 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 intercellular signal molecule#PC00207 HUMAN|HGNC=13051|UniProtKB=O75312 O75312 ZPR1 PTHR10876:SF3 ZINC FINGER PROTEIN ZPR1 ZINC FINGER PROTEIN ZPR1 binding#GO:0005488;protein binding#GO:0005515 gene expression#GO:0010467;protein maturation#GO:0051604;protein folding#GO:0006457;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152 membraneless organelle#GO:0043228;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;nuclear body#GO:0016604;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233 HUMAN|HGNC=13597|UniProtKB=Q8N3Y1 Q8N3Y1 FBXW8 PTHR44019:SF11 WD REPEAT-CONTAINING PROTEIN 55 F-BOX_WD REPEAT-CONTAINING PROTEIN 8 primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein modification by small protein conjugation#GO:0032446;cellular process#GO:0009987;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412 transferase complex#GO:1990234;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461 non-motor microtubule binding protein#PC00166;cytoskeletal protein#PC00085 HUMAN|HGNC=6517|UniProtKB=P18428 P18428 LBP PTHR10504:SF66 BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED LIPOPOLYSACCHARIDE-BINDING PROTEIN lipopolysaccharide binding#GO:0001530;binding#GO:0005488;carbohydrate derivative binding#GO:0097367;lipid binding#GO:0008289 defense response to Gram-negative bacterium#GO:0050829;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;defense response to Gram-positive bacterium#GO:0050830;response to molecule of bacterial origin#GO:0002237;regulation of cell activation#GO:0050865;positive regulation of multicellular organismal process#GO:0051240;regulation of leukocyte activation#GO:0002694;cell activation involved in immune response#GO:0002263;response to oxygen-containing compound#GO:1901700;defense response to bacterium#GO:0042742;cellular response to chemical stimulus#GO:0070887;immune system process#GO:0002376;regulation of multicellular organismal process#GO:0051239;response to chemical#GO:0042221;myeloid leukocyte activation#GO:0002274;cellular response to lipid#GO:0071396;response to lipid#GO:0033993;defense response to other organism#GO:0098542;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;regulation of macrophage activation#GO:0043030;defense response to symbiont#GO:0140546;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987;response to biotic stimulus#GO:0009607;cellular response to lipopolysaccharide#GO:0071222;response to stress#GO:0006950;positive regulation of immune system process#GO:0002684;response to lipopolysaccharide#GO:0032496;positive regulation of leukocyte activation#GO:0002696;immune effector process#GO:0002252;leukocyte activation involved in immune response#GO:0002366;cell surface receptor signaling pathway#GO:0007166;response to external biotic stimulus#GO:0043207;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;leukocyte activation#GO:0045321;cellular response to biotic stimulus#GO:0071216;acute inflammatory response#GO:0002526;cell communication#GO:0007154;inflammatory response#GO:0006954;cell activation#GO:0001775;response to bacterium#GO:0009617;lipopolysaccharide-mediated signaling pathway#GO:0031663;biological regulation#GO:0065007;positive regulation of cell activation#GO:0050867;response to other organism#GO:0051707;multicellular organismal process#GO:0032501;immune response#GO:0006955;positive regulation of cellular process#GO:0048522;response to external stimulus#GO:0009605;defense response#GO:0006952;cellular response to molecule of bacterial origin#GO:0071219;macrophage activation#GO:0042116;innate immune response#GO:0045087 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090 HUMAN|HGNC=21568|UniProtKB=Q8N5C1 Q8N5C1 CALHM5 PTHR32261:SF8 CALCIUM HOMEOSTASIS MODULATOR PROTEIN CALCIUM HOMEOSTASIS MODULATOR PROTEIN 5 monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 voltage-gated ion channel#PC00241 HUMAN|HGNC=30529|UniProtKB=A8MQ03 A8MQ03 CYSRT1 PTHR37879:SF1 CYSTEINE-RICH TAIL PROTEIN 1 CYSTEINE-RICH TAIL PROTEIN 1 HUMAN|HGNC=612|UniProtKB=P05090 P05090 APOD PTHR10612:SF65 APOLIPOPROTEIN D APOLIPOPROTEIN D binding#GO:0005488;small molecule binding#GO:0036094;sterol binding#GO:0032934;alcohol binding#GO:0043178;cholesterol binding#GO:0015485;lipid binding#GO:0008289;steroid binding#GO:0005496 primary metabolic process#GO:0044238;response to stress#GO:0006950;cellular process#GO:0009987;response to chemical#GO:0042221;response to stimulus#GO:0050896;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;response to oxygen-containing compound#GO:1901700;response to oxidative stress#GO:0006979;response to reactive oxygen species#GO:0000302 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 apolipoprotein#PC00052 HUMAN|HGNC=1806|UniProtKB=Q99626 Q99626 CDX2 PTHR24332:SF27 HOMEOBOX PROTEIN CDX HOMEOBOX PROTEIN CDX-2 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 cellular process#GO:0009987;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;embryonic pattern specification#GO:0009880;tube development#GO:0035295;embryo development#GO:0009790;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regionalization#GO:0003002;regulation of nucleobase-containing compound metabolic process#GO:0019219;developmental process#GO:0032502;anterior/posterior pattern specification#GO:0009952;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;anterior/posterior axis specification#GO:0009948;multicellular organism development#GO:0007275;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;pattern specification process#GO:0007389;animal gross anatomical part developmental process#GO:0160108;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=23059|UniProtKB=Q96GW7 Q96GW7 BCAN PTHR22804:SF41 AGGRECAN/VERSICAN PROTEOGLYCAN BREVICAN CORE PROTEIN skeletal system development#GO:0001501;multicellular organism development#GO:0007275;anatomical structure development#GO:0048856;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502;central nervous system development#GO:0007417;multicellular organismal process#GO:0032501;nervous system development#GO:0007399 cell junction#GO:0030054;extracellular region#GO:0005576;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;synapse#GO:0045202;cell periphery#GO:0071944;external encapsulating structure#GO:0030312;membrane#GO:0016020;extracellular matrix#GO:0031012 extracellular matrix glycoprotein#PC00100;extracellular matrix protein#PC00102 HUMAN|HGNC=15866|UniProtKB=Q9NV56 Q9NV56 MRGBP PTHR13581:SF5 MRG-BINDING PROTEIN MRG_MORF4L-BINDING PROTEIN regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular protein-containing complex#GO:0140535;histone acetyltransferase complex#GO:0000123;membraneless organelle#GO:0043228;transferase complex#GO:1990234;intracellular membraneless organelle#GO:0043232;H4 histone acetyltransferase complex#GO:1902562;protein-containing complex#GO:0032991;NuA4 histone acetyltransferase complex#GO:0035267;chromatin#GO:0000785;intracellular anatomical structure#GO:0005622;acetyltransferase complex#GO:1902493;protein acetyltransferase complex#GO:0031248;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;organelle#GO:0043226;chromosome#GO:0005694 HUMAN|HGNC=35409|UniProtKB=A6NL88 A6NL88 SHISA7 PTHR31774:SF2 PROTEIN SHISA-9-RELATED PROTEIN SHISA-7 protein binding#GO:0005515;signaling receptor binding#GO:0005102;GABA receptor binding#GO:0050811;binding#GO:0005488 synapse organization#GO:0050808;receptor clustering#GO:0043113;localization within membrane#GO:0051668;regulation of signaling#GO:0023051;regulation of biological quality#GO:0065008;cell communication#GO:0007154;localization#GO:0051179;cellular localization#GO:0051641;regulation of biological process#GO:0050789;protein localization to membrane#GO:0072657;cellular component organization#GO:0016043;modulation of chemical synaptic transmission#GO:0050804;signaling#GO:0023052;postsynapse organization#GO:0099173;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;cell junction organization#GO:0034330;regulation of synaptic plasticity#GO:0048167;intracellular protein localization#GO:0008104;cellular component organization or biogenesis#GO:0071840;regulation of neuronal synaptic plasticity#GO:0048168;cellular process#GO:0009987;macromolecule localization#GO:0033036;membrane organization#GO:0061024;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;regulation of trans-synaptic signaling#GO:0099177 protein-containing complex#GO:0032991;neuron projection#GO:0043005;cell leading edge#GO:0031252;transporter complex#GO:1990351;cell junction#GO:0030054;synaptic membrane#GO:0097060;neuron spine#GO:0044309;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;dendritic spine#GO:0043197;postsynapse#GO:0098794;cell projection membrane#GO:0031253;leading edge membrane#GO:0031256;postsynaptic membrane#GO:0045211;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;monoatomic ion channel complex#GO:0034702;neuron to neuron synapse#GO:0098984;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;cell periphery#GO:0071944;membrane#GO:0016020;signaling receptor complex#GO:0043235;neuron projection membrane#GO:0032589;plasma membrane bounded cell projection#GO:0120025;asymmetric synapse#GO:0032279;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;transmembrane transporter complex#GO:1902495;postsynaptic density#GO:0014069;dendritic tree#GO:0097447;dendrite#GO:0030425 HUMAN|HGNC=11346|UniProtKB=Q13007 Q13007 IL24 PTHR48482:SF4 INTERLEUKIN-19-RELATED INTERLEUKIN-24 signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;cytokine activity#GO:0005125;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018 immune response#GO:0006955;immune system process#GO:0002376;response to stimulus#GO:0050896 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=12593|UniProtKB=P22415 P22415 USF1 PTHR46117:SF1 FI24210P1 UPSTREAM STIMULATORY FACTOR 1 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=8590|UniProtKB=Q13153 Q13153 PAK1 PTHR48015:SF20 SERINE/THREONINE-PROTEIN KINASE TAO SERINE_THREONINE-PROTEIN KINASE PAK 1 transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 regulation of signaling#GO:0023051;cellular response to stress#GO:0033554;regulation of intracellular signal transduction#GO:1902531;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular component organization#GO:0051128;regulation of MAPK cascade#GO:0043408;regulation of axonogenesis#GO:0050770;regulation of anatomical structure morphogenesis#GO:0022603;cellular process#GO:0009987;regulation of neuron projection development#GO:0010975;signal transduction#GO:0007165;response to stress#GO:0006950;regulation of actin cytoskeleton organization#GO:0032956;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;response to starvation#GO:0042594;regulation of cell communication#GO:0010646;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;cell motility#GO:0048870;regulation of cytoskeleton organization#GO:0051493;regulation of response to stimulus#GO:0048583;cellular response to nutrient levels#GO:0031669;regulation of actin filament-based process#GO:0032970;regulation of cell projection organization#GO:0031344;cellular response to starvation#GO:0009267;regulation of plasma membrane bounded cell projection organization#GO:0120035;response to nutrient levels#GO:0031667;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;cell migration#GO:0016477 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 Axon guidance mediated by semaphorins#P00007>PAK#P00331;CCKR signaling map#P06959>PAK1#P07065;Cytoskeletal regulation by Rho GTPase#P00016>PAK#P00517;Angiogenesis#P00005>PAK#P00249;T cell activation#P00053>PAK#P01319;Ras Pathway#P04393>PAK#P04553;CCKR signaling map#P06959>PAK#P07091;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PAK#P00837 HUMAN|HGNC=27252|UniProtKB=Q7Z2G1 Q7Z2G1 H2BW1 PTHR23428:SF392 HISTONE H2B HISTONE H2B TYPE W-T immune system process#GO:0002376;response to bacterium#GO:0009617;defense response to bacterium#GO:0042742;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;humoral immune response#GO:0006959;antimicrobial humoral response#GO:0019730;antibacterial humoral response#GO:0019731;innate immune response#GO:0045087;defense response#GO:0006952;response to external stimulus#GO:0009605;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;immune response#GO:0006955;defense response to symbiont#GO:0140546;defense response to other organism#GO:0098542;response to other organism#GO:0051707 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=14395|UniProtKB=Q96T59 Q96T59 CDRT15 PTHR16471:SF3 CMT1A DUPLICATED REGION TRANSCRIPT 15 PROTEIN-LIKE PROTEIN CMT1A DUPLICATED REGION TRANSCRIPT 15 PROTEIN HUMAN|HGNC=28302|UniProtKB=Q96CN5 Q96CN5 LRRC45 PTHR23170:SF3 NY-REN-58 ANTIGEN LEUCINE-RICH REPEAT-CONTAINING PROTEIN 45 HUMAN|HGNC=18025|UniProtKB=Q5JTJ3 Q5JTJ3 COA6 PTHR46690:SF1 CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6 HOMOLOG CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6 HOMOLOG oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;catalytic activity#GO:0003824;disulfide oxidoreductase activity#GO:0015036;oxidoreductase activity#GO:0016491;catalytic activity, acting on a protein#GO:0140096;protein-disulfide reductase activity#GO:0015035 cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;respiratory chain complex IV assembly#GO:0008535;protein-containing complex organization#GO:0043933;cytochrome complex assembly#GO:0017004 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 chaperone#PC00072 HUMAN|HGNC=23708|UniProtKB=Q6ZR52 Q6ZR52 ZNF493 PTHR24376:SF248 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 493 gene-specific transcriptional regulator#PC00264;zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=27040|UniProtKB=Q56A73 Q56A73 SPIN4 PTHR10405:SF9 SPINDLIN SPINDLIN-4 histone reader activity#GO:0140566;histone H3 reader activity#GO:0140006;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;chromatin-protein adaptor activity#GO:0140463 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=14650|UniProtKB=Q13427 Q13427 PPIG PTHR11071:SF292 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE G cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 chaperone#PC00072 HUMAN|HGNC=20270|UniProtKB=Q9NWQ9 Q9NWQ9 C14orf119 PTHR16260:SF4 SIMILAR TO 1700123O20RIK PROTEIN SUBFAMILY NOT NAMED HUMAN|HGNC=10771|UniProtKB=Q15427 Q15427 SF3B4 PTHR48030:SF4 SPLICING FACTOR 3B SUBUNIT 4 SPLICING FACTOR 3B SUBUNIT 4 nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;mRNA splicing, via spliceosome#GO:0000398;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 U2 snRNP#GO:0005686;nuclear protein-containing complex#GO:0140513;Sm-like protein family complex#GO:0120114;nucleus#GO:0005634;small nuclear ribonucleoprotein complex#GO:0030532;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;precatalytic spliceosome#GO:0071011;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;spliceosomal snRNP complex#GO:0097525;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 RNA splicing factor#PC00148 HUMAN|HGNC=17316|UniProtKB=O43615 O43615 TIMM44 PTHR10721:SF1 MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44 MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44 protein complex scaffold activity#GO:0140378;structural molecule activity#GO:0005198 cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;macromolecule localization#GO:0033036;protein import into mitochondrial matrix#GO:0030150;mitochondrial protein import pathway#GO:7770058;protein transmembrane transport#GO:0071806;intracellular protein transport#GO:0006886;transport#GO:0006810;protein transmembrane import into intracellular organelle#GO:0044743;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;intracellular protein transmembrane transport#GO:0065002;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;protein localization to mitochondrion#GO:0070585;protein localization to organelle#GO:0033365;mitochondrial transport#GO:0006839;mitochondrial transmembrane transport#GO:1990542;protein transport#GO:0015031;transmembrane transport#GO:0055085;cellular localization#GO:0051641;localization#GO:0051179 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle envelope#GO:0031967;membrane protein complex#GO:0098796;organelle lumen#GO:0043233;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;inner mitochondrial membrane protein complex#GO:0098800;organelle membrane#GO:0031090;mitochondrial inner membrane#GO:0005743;membrane-enclosed lumen#GO:0031974;membrane#GO:0016020;TIM23 mitochondrial import inner membrane translocase complex#GO:0005744;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;cytoplasm#GO:0005737 transporter#PC00227 HUMAN|HGNC=12733|UniProtKB=Q9Y6W5 Q9Y6W5 WASF2 PTHR12902:SF6 WASP-1 ACTIN-BINDING PROTEIN WASF2 protein kinase A binding#GO:0051018;binding#GO:0005488;protein kinase A regulatory subunit binding#GO:0034237;protein binding#GO:0005515;protein-containing complex binding#GO:0044877 regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of supramolecular fiber organization#GO:1902903;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;actin filament-based process#GO:0030029;positive regulation of cellular component organization#GO:0051130;positive regulation of organelle organization#GO:0010638;cellular process#GO:0009987;regulation of actin filament organization#GO:0110053;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;organelle organization#GO:0006996;regulation of actin cytoskeleton organization#GO:0032956;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;regulation of actin filament-based process#GO:0032970;regulation of actin nucleation#GO:0051125;cellular component organization or biogenesis#GO:0071840 cell leading edge#GO:0031252;lamellipodium#GO:0030027;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165;actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=5910|UniProtKB=P01718 P01718 IGLV3-27 PTHR23267:SF375 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN LAMBDA VARIABLE 3-27 response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 protein-containing complex#GO:0032991 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=28171|UniProtKB=Q9BSH5 Q9BSH5 HDHD3 PTHR46191:SF2 FAMILY NOT NAMED HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 3 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=29647|UniProtKB=Q5TCQ9 Q5TCQ9 MAGI3 PTHR10316:SF10 MEMBRANE ASSOCIATED GUANYLATE KINASE-RELATED MEMBRANE-ASSOCIATED GUANYLATE KINASE, WW AND PDZ DOMAIN-CONTAINING PROTEIN 3 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 regulation of biological quality#GO:0065008;regulation of protein localization#GO:0032880;regulation of localization#GO:0032879;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of protein localization to membrane#GO:1905475;regulation of biological process#GO:0050789;signal transduction#GO:0007165;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 adherens junction#GO:0005912;anchoring junction#GO:0070161;intracellular anatomical structure#GO:0005622;cell junction#GO:0030054;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;synapse#GO:0045202;cell-cell junction#GO:0005911 HUMAN|Gene=YI025_HUMAN|UniProtKB=Q8N1Y9 Q8N1Y9 PTHR34344:SF1 UPF0184 PROTEIN C9ORF16 BUBLIN COILED-COIL PROTEIN cellular component assembly#GO:0022607;intermediate filament cytoskeleton organization#GO:0045104;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;supramolecular fiber organization#GO:0097435;intermediate filament bundle assembly#GO:0045110;intermediate filament-based process#GO:0045103;intermediate filament organization#GO:0045109 polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;cell junction#GO:0030054;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;supramolecular fiber#GO:0099512;intermediate filament#GO:0005882;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;organelle#GO:0043226;supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232 HUMAN|HGNC=20492|UniProtKB=Q96IL0 Q96IL0 COA8 PTHR31107:SF2 APOPTOGENIC PROTEIN 1, MITOCHONDRIAL CYTOCHROME C OXIDASE ASSEMBLY FACTOR 8 mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=32459|UniProtKB=P0CG32 P0CG32 ZCCHC18 PTHR23095:SF48 PARANEOPLASTIC ANTIGEN ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 18 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 transcription cofactor#PC00217 HUMAN|HGNC=8029|UniProtKB=O95631 O95631 NTN1 PTHR10574:SF378 NETRIN/LAMININ-RELATED NETRIN-1 system development#GO:0048731;anatomical structure development#GO:0048856;axon guidance#GO:0007411;axon development#GO:0061564;plasma membrane bounded cell projection organization#GO:0120036;multicellular organismal process#GO:0032501;tissue development#GO:0009888;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;anatomical structure morphogenesis#GO:0009653;motor neuron axon guidance#GO:0008045;cellular component organization#GO:0016043;cell development#GO:0048468;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell morphogenesis#GO:0000902;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;axonogenesis#GO:0007409;neuron development#GO:0048666;dendrite development#GO:0016358;cellular process#GO:0009987;neuron projection development#GO:0031175;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell projection morphogenesis#GO:0048858;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275 cellular anatomical structure#GO:0110165;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576;basement membrane#GO:0005604 extracellular matrix protein#PC00102 Axon guidance mediated by Slit/Robo#P00008>Netrin#P00344;Axon guidance mediated by netrin#P00009>Netrin#P00357 HUMAN|HGNC=20867|UniProtKB=Q969V1 Q969V1 MCHR2 PTHR24230:SF7 G-PROTEIN COUPLED RECEPTOR MELANIN-CONCENTRATING HORMONE RECEPTOR 2 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888;neuropeptide receptor activity#GO:0008188 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;neuropeptide signaling pathway#GO:0007218;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HUMAN|HGNC=21086|UniProtKB=Q86YT6 Q86YT6 MIB1 PTHR24202:SF53 E3 UBIQUITIN-PROTEIN LIGASE MIB2 E3 UBIQUITIN-PROTEIN LIGASE MIB1 catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787 metabolic process#GO:0008152;transport#GO:0006810;cell surface receptor signaling pathway#GO:0007166;import into cell#GO:0098657;establishment of localization#GO:0051234;Notch signaling pathway#GO:0007219;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;signal transduction#GO:0007165;post-translational protein modification#GO:0043687;biological regulation#GO:0065007;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;localization#GO:0051179;cell communication#GO:0007154;protein modification process#GO:0036211;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;protein modification by small protein conjugation#GO:0032446;regulation of cellular process#GO:0050794;endocytosis#GO:0006897;response to stimulus#GO:0050896;signaling#GO:0023052 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=20335|UniProtKB=Q9UIL1 Q9UIL1 SCOC PTHR21614:SF0 SHORT COILED COIL PROTEIN SHORT COILED-COIL PROTEIN intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus subcompartment#GO:0098791 HUMAN|HGNC=6614|UniProtKB=P53671 P53671 LIMK2 PTHR46485:SF1 LIM DOMAIN KINASE 1 LIM DOMAIN KINASE 2 catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674 organelle organization#GO:0006996;cellular component organization#GO:0016043;actin filament-based process#GO:0030029;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;actin cytoskeleton organization#GO:0030036;cytoskeleton organization#GO:0007010 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 HUMAN|HGNC=4392|UniProtKB=Q5JWF2 Q5JWF2 GNAS PTHR10218:SF348 GTP-BINDING PROTEIN ALPHA SUBUNIT GUANINE NUCLEOTIDE-BINDING PROTEIN G(S) SUBUNIT ALPHA ISOFORMS XLAS signaling receptor binding#GO:0005102;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924;protein binding#GO:0005515;hydrolase activity#GO:0016787;G protein-coupled receptor binding#GO:0001664;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;molecular function regulator activity#GO:0098772 response to nitrogen compound#GO:1901698;cell communication#GO:0007154;nervous system process#GO:0050877;response to oxygen-containing compound#GO:1901700;sensory perception#GO:0007600;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;system process#GO:0003008;renal absorption#GO:0070293;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;sensory perception of chemical stimulus#GO:0007606;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;cellular response to nitrogen compound#GO:1901699;response to chemical#GO:0042221;renal system process#GO:0003014;cellular process#GO:0009987;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;G protein-coupled dopamine receptor signaling pathway#GO:0007212 cytoplasmic side of plasma membrane#GO:0009898;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cellular anatomical structure#GO:0110165;extrinsic component of cytoplasmic side of plasma membrane#GO:0031234;catalytic complex#GO:1902494;side of membrane#GO:0098552;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;cell periphery#GO:0071944;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cytoplasmic side of membrane#GO:0098562;extrinsic component of plasma membrane#GO:0019897;extrinsic component of membrane#GO:0019898 heterotrimeric G-protein#PC00117;G-protein#PC00020 Beta3 adrenergic receptor signaling pathway#P04379>G-Protein#P04448;Beta1 adrenergic receptor signaling pathway#P04377>G-Protein#P04436;Endothelin signaling pathway#P00019>Gs#P00584;Enkephalin release#P05913>G-Protein (s)#P05977;5HT4 type receptor mediated signaling pathway#P04376>G-protein#P04430;Histamine H2 receptor mediated signaling pathway#P04386>G-Protein#P04490;Beta2 adrenergic receptor signaling pathway#P04378>G-Protein#P04443;Gonadotropin-releasing hormone receptor pathway#P06664>gnas#P06717;Cortocotropin releasing factor receptor signaling pathway#P04380>G-Protein#P04458 HUMAN|HGNC=37266|UniProtKB=P0CJ90 P0CJ90 DUX4L7 PTHR46123:SF3 MIX-TYPE HOMEOBOX GENE 1-RELATED DOUBLE HOMEOBOX PROTEIN 1-RELATED DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=15877|UniProtKB=Q9BV94 Q9BV94 EDEM2 PTHR45679:SF10 ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2 ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2 hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798 macromolecule metabolic process#GO:0043170;endoplasmic reticulum unfolded protein response#GO:0030968;carbohydrate derivative metabolic process#GO:1901135;biological regulation#GO:0065007;response to endoplasmic reticulum stress#GO:0034976;cellular response to unfolded protein#GO:0034620;cellular response to topologically incorrect protein#GO:0035967;protein metabolic process#GO:0019538;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;ERAD pathway#GO:0036503;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;carbohydrate derivative catabolic process#GO:1901136;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;response to stress#GO:0006950;cellular process#GO:0009987;signal transduction#GO:0007165;response to chemical#GO:0042221;proteasomal protein catabolic process#GO:0010498;response to oxygen-containing compound#GO:1901700;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;response to unfolded protein#GO:0006986;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;response to topologically incorrect protein#GO:0035966;signaling#GO:0023052 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=9824|UniProtKB=P43351 P43351 RAD52 PTHR12132:SF1 DNA REPAIR AND RECOMBINATION PROTEIN RAD52, RAD59 DNA REPAIR PROTEIN RAD52 HOMOLOG protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 cellular response to stress#GO:0033554;recombinational repair#GO:0000725;mitotic recombination#GO:0006312;telomere organization#GO:0032200;double-strand break repair via homologous recombination#GO:0000724;double-strand break repair via single-strand annealing#GO:0045002;cellular response to stimulus#GO:0051716;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;response to stimulus#GO:0050896;DNA damage response#GO:0006974;DNA recombination#GO:0006310;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;chromosome organization#GO:0051276;double-strand break repair#GO:0006302;telomere maintenance#GO:0000723;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;organelle organization#GO:0006996;response to stress#GO:0006950;nucleobase-containing compound metabolic process#GO:0006139 nucleus#GO:0005634;site of double-strand break#GO:0035861;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;site of DNA damage#GO:0090734;membraneless organelle#GO:0043228 DNA metabolism protein#PC00009 HUMAN|HGNC=18515|UniProtKB=Q9BQJ4 Q9BQJ4 TMEM47 PTHR14399:SF3 P53-INDUCED PROTEIN RELATED TRANSMEMBRANE PROTEIN 47 cellular process#GO:0009987;cell adhesion#GO:0007155;cell-cell adhesion#GO:0098609 cell-cell junction#GO:0005911;cell junction#GO:0030054;cellular anatomical structure#GO:0110165;anchoring junction#GO:0070161 HUMAN|HGNC=15997|UniProtKB=Q8IVL1 Q8IVL1 NAV2 PTHR12784:SF6 STEERIN NEURON NAVIGATOR 2 developmental process#GO:0032502;animal gross anatomical part developmental process#GO:0160108;nervous system development#GO:0007399;system development#GO:0048731;anatomical structure development#GO:0048856;multicellular organismal process#GO:0032501;multicellular organism development#GO:0007275 HUMAN|HGNC=2060|UniProtKB=O14967 O14967 CLGN PTHR11073:SF7 CALRETICULIN AND CALNEXIN CALMEGIN cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167 cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;response to endoplasmic reticulum stress#GO:0034976;ERAD pathway#GO:0036503;protein metabolic process#GO:0019538;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;protein folding#GO:0006457;response to stimulus#GO:0050896;catabolic process#GO:0009056;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;response to stress#GO:0006950;proteasomal protein catabolic process#GO:0010498;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604;response to chemical#GO:0042221 membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HUMAN|HGNC=25552|UniProtKB=Q5VTB9 Q5VTB9 RNF220 PTHR13459:SF3 E3 UBIQUITIN-PROTEIN LIGASE RNF220 ISOFORM X1 E3 UBIQUITIN-PROTEIN LIGASE RNF220 transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein modification process#GO:0036211 HUMAN|HGNC=2171|UniProtKB=Q12860 Q12860 CNTN1 PTHR10075:SF148 BASIGIN RELATED CONTACTIN-1 cell adhesion molecule#PC00069 HUMAN|HGNC=30989|UniProtKB=Q8IY31 Q8IY31 IFT20 PTHR31978:SF3 INTRAFLAGELLAR TRANSPORT PROTEIN 20 HOMOLOG INTRAFLAGELLAR TRANSPORT PROTEIN 20 HOMOLOG organelle assembly#GO:0070925;cilium organization#GO:0044782;localization#GO:0051179;cilium assembly#GO:0060271;cellular component organization#GO:0016043;protein localization to cilium#GO:0061512;protein localization to organelle#GO:0033365;cell projection organization#GO:0030030;plasma membrane bounded cell projection assembly#GO:0120031;intracellular protein localization#GO:0008104;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cell projection assembly#GO:0030031;macromolecule localization#GO:0033036;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607 neuron projection#GO:0043005;microtubule cytoskeleton#GO:0015630;ciliary base#GO:0097546;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;centrosome#GO:0005813;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;ciliary basal body#GO:0036064;membraneless organelle#GO:0043228;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cilium#GO:0005929;intracellular organelle#GO:0043229;intraciliary transport particle#GO:0030990;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;non-motile cilium#GO:0097730 HUMAN|HGNC=5395|UniProtKB=Q16666 Q16666 IFI16 PTHR12200:SF5 INTERFERON-INDUCIBLE PROTEIN AIM2 FAMILY MEMBER GAMMA-INTERFERON-INDUCIBLE PROTEIN 16 nucleic acid binding#GO:0003676;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677 regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;regulation of response to biotic stimulus#GO:0002831;response to stimulus#GO:0050896;regulation of immune system process#GO:0002682;regulation of immune response#GO:0050776;regulation of defense response#GO:0031347;immune system process#GO:0002376;response to peptide#GO:1901652;activation of immune response#GO:0002253;positive regulation of biological process#GO:0048518;positive regulation of innate immune response#GO:0045089;activation of innate immune response#GO:0002218;positive regulation of immune system process#GO:0002684;biological regulation#GO:0065007;response to chemical#GO:0042221;positive regulation of response to stimulus#GO:0048584;response to cytokine#GO:0034097;regulation of response to external stimulus#GO:0032101;positive regulation of immune response#GO:0050778;positive regulation of defense response#GO:0031349;regulation of response to stimulus#GO:0048583;regulation of response to stress#GO:0080134;positive regulation of response to biotic stimulus#GO:0002833;regulation of innate immune response#GO:0045088;positive regulation of response to external stimulus#GO:0032103 intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;nucleus#GO:0005634;cytosol#GO:0005829;membrane-enclosed lumen#GO:0031974;membraneless organelle#GO:0043228 DNA-binding transcription factor#PC00218 HUMAN|HGNC=18921|UniProtKB=G5E9R7 G5E9R7 KRTAP4-16 PTHR23262:SF183 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 4-11-RELATED multicellular organismal process#GO:0032501 structural protein#PC00211 HUMAN|HGNC=1952|UniProtKB=P20309 P20309 CHRM3 PTHR24247:SF183 5-HYDROXYTRYPTAMINE RECEPTOR MUSCARINIC ACETYLCHOLINE RECEPTOR M3 molecular transducer activity#GO:0060089;postsynaptic neurotransmitter receptor activity#GO:0098960;transmembrane signaling receptor activity#GO:0004888;acetylcholine receptor activity#GO:0015464;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;G protein-coupled amine receptor activity#GO:0008227;neurotransmitter receptor activity#GO:0030594 regulation of smooth muscle contraction#GO:0006940;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway#GO:0007193;regulation of system process#GO:0044057;regulation of multicellular organismal process#GO:0051239;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;cellular response to nitrogen compound#GO:1901699;acetylcholine receptor signaling pathway#GO:0095500;response to chemical#GO:0042221;cellular process#GO:0009987;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;synaptic signaling#GO:0099536;response to nitrogen compound#GO:1901698;cell communication#GO:0007154;response to oxygen-containing compound#GO:1901700;trans-synaptic signaling#GO:0099537;G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887;regulation of muscle contraction#GO:0006937;signaling#GO:0023052;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;regulation of muscle system process#GO:0090257 cell junction#GO:0030054;dendritic tree#GO:0097447;dendrite#GO:0030425;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;synapse#GO:0045202;cell periphery#GO:0071944;neuron projection#GO:0043005;membrane#GO:0016020 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GqPCR#P00730;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GoPCR#P00725;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>mAChR1/3#P01069;Alzheimer disease-amyloid secretase pathway#P00003>Muscarinic acetylcholine receptors#P00083 HUMAN|HGNC=11771|UniProtKB=Q15582 Q15582 TGFBI PTHR10900:SF82 PERIOSTIN-RELATED TRANSFORMING GROWTH FACTOR-BETA-INDUCED PROTEIN IG-H3 protein binding#GO:0005515;cell adhesion molecule binding#GO:0050839;binding#GO:0005488 extracellular structure organization#GO:0043062;cell adhesion#GO:0007155;cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;external encapsulating structure organization#GO:0045229;homophilic cell-cell adhesion#GO:0007156;cell-cell adhesion#GO:0098609;cellular component organization#GO:0016043;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576 cell adhesion molecule#PC00069 HUMAN|HGNC=3512|UniProtKB=Q16394 Q16394 EXT1 PTHR11062:SF97 EXOSTOSIN HEPARAN SULFATE GLYCOSYLTRANSFERASE -RELATED EXOSTOSIN-1 UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;acetylglucosaminyltransferase activity#GO:0008375;catalytic activity#GO:0003824;glucuronosyltransferase activity#GO:0015020;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794 glycosyltransferase#PC00111;transferase#PC00220 HUMAN|HGNC=25015|UniProtKB=Q9BTX3 Q9BTX3 TMEM208 PTHR13505:SF7 TRANSMEMBRANE PROTEIN 208 TRANSMEMBRANE PROTEIN 208 membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020 HUMAN|HGNC=6362|UniProtKB=Q9P0G3 Q9P0G3 KLK14 PTHR24271:SF48 KALLIKREIN-RELATED KALLIKREIN-14 serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;serine-type peptidase activity#GO:0008236;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;catalytic activity#GO:0003824 metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058 intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;extracellular region#GO:0005576;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;secretory vesicle#GO:0099503;intracellular vesicle#GO:0097708;vesicle#GO:0031982 serine protease#PC00203 HUMAN|HGNC=3423|UniProtKB=P11678 P11678 EPX PTHR11475:SF145 OXIDASE/PEROXIDASE EOSINOPHIL PEROXIDASE oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on peroxide as acceptor#GO:0016684;catalytic activity#GO:0003824;antioxidant activity#GO:0016209;peroxidase activity#GO:0004601 response to stimulus#GO:0050896;response to other organism#GO:0051707;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;defense response#GO:0006952;response to external stimulus#GO:0009605;response to bacterium#GO:0009617;defense response to bacterium#GO:0042742 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 metabolite interconversion enzyme#PC00262;peroxidase#PC00180 HUMAN|HGNC=5920|UniProtKB=A0A075B6I1 A0A075B6I1 IGLV4-60 PTHR23267:SF323 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN LAMBDA VARIABLE 4-60 response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 protein-containing complex#GO:0032991 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=10703|UniProtKB=O95486 O95486 SEC24A PTHR13803:SF1 SEC24-RELATED PROTEIN PROTEIN TRANSPORT PROTEIN SEC24A transition metal ion binding#GO:0046914;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;cation binding#GO:0043169;metal ion binding#GO:0046872;protein binding#GO:0005515;zinc ion binding#GO:0008270;SNARE binding#GO:0000149 cellular component organization#GO:0016043;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;localization#GO:0051179;cellular localization#GO:0051641;COPII-coated vesicle budding#GO:0090114;membrane organization#GO:0061024;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle organization#GO:0006996;vesicle organization#GO:0016050;vesicle budding from membrane#GO:0006900;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;Golgi vesicle transport#GO:0048193;transport#GO:0006810;intracellular transport#GO:0046907 organelle#GO:0043226;cellular anatomical structure#GO:0110165;coated vesicle membrane#GO:0030662;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;vesicle#GO:0031982;coated membrane#GO:0048475;COPII-coated ER to Golgi transport vesicle#GO:0030134;membrane coat#GO:0030117;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;coated vesicle#GO:0030135;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;transport vesicle#GO:0030133;transport vesicle membrane#GO:0030658;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;vesicle coat#GO:0030120;cytoplasm#GO:0005737;vesicle membrane#GO:0012506;membrane#GO:0016020;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;ER to Golgi transport vesicle membrane#GO:0012507;endoplasmic reticulum exit site#GO:0070971;endoplasmic reticulum#GO:0005783 vesicle coat protein#PC00235 HUMAN|HGNC=14178|UniProtKB=Q96QI5 Q96QI5 HS3ST6 PTHR10605:SF62 HEPARAN SULFATE SULFOTRANSFERASE HEPARAN SULFATE GLUCOSAMINE 3-O-SULFOTRANSFERASE 6 transferase activity, transferring sulphur-containing groups#GO:0016782;sulfotransferase activity#GO:0008146;transferase activity#GO:0016740;catalytic activity#GO:0003824 transferase#PC00220;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=1002|UniProtKB=Q8N143 Q8N143 BCL6B PTHR24399:SF37 ZINC FINGER AND BTB DOMAIN-CONTAINING B-CELL CLL_LYMPHOMA 6 MEMBER B PROTEIN sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription repressor activity#GO:0001217;transcription regulator activity#GO:0140110;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of developmental process#GO:0050793;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of DNA-templated transcription#GO:0006355;regulation of cell population proliferation#GO:0042127;regulation of defense response#GO:0031347;regulation of inflammatory response#GO:0050727;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;immune response#GO:0006955;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of cytokine production#GO:0001817;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of response to stimulus#GO:0048583;regulation of cell differentiation#GO:0045595;negative regulation of cellular process#GO:0048523;regulation of response to stress#GO:0080134;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;immune system process#GO:0002376;regulation of multicellular organismal process#GO:0051239;regulation of response to external stimulus#GO:0032101;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231 DNA-binding transcription factor#PC00218;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=16655|UniProtKB=Q86TS9 Q86TS9 MRPL52 PTHR34090:SF1 39S RIBOSOMAL PROTEIN L52, MITOCHONDRIAL LARGE RIBOSOMAL SUBUNIT PROTEIN ML52 metabolic process#GO:0008152;translation#GO:0006412;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058 mitochondrial large ribosomal subunit#GO:0005762;membraneless organelle#GO:0043228;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;membrane-enclosed lumen#GO:0031974;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrial ribosome#GO:0005761;organellar ribosome#GO:0000313;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;ribosome#GO:0005840;organelle lumen#GO:0043233 translational protein#PC00263;ribosomal protein#PC00202 HUMAN|HGNC=2148|UniProtKB=P29973 P29973 CNGA1 PTHR45638:SF9 CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A CYCLIC NUCLEOTIDE-GATED CHANNEL ALPHA-1 ligand-gated monoatomic ion channel activity#GO:0015276;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;channel activity#GO:0015267;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;nucleotide binding#GO:0000166;monoatomic cation channel activity#GO:0005261;guanyl nucleotide binding#GO:0019001;gated channel activity#GO:0022836;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;guanyl ribonucleotide binding#GO:0032561;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;heterocyclic compound binding#GO:1901363;monoatomic ion transmembrane transporter activity#GO:0015075;purine ribonucleotide binding#GO:0032555;monoatomic ion channel activity#GO:0005216 monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;multicellular organismal process#GO:0032501;cellular process#GO:0009987;system process#GO:0003008;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;sensory perception#GO:0007600;transport#GO:0006810;nervous system process#GO:0050877;sensory perception of chemical stimulus#GO:0007606 cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cation channel complex#GO:0034703 ligand-gated ion channel#PC00141;ion channel#PC00133 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>cGMP-gated ion channel#P00752 HUMAN|HGNC=13022|UniProtKB=Q9UJW7 Q9UJW7 ZNF229 PTHR24376:SF103 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 229 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=23745|UniProtKB=Q5JTN6 Q5JTN6 WDR38 PTHR22847:SF626 WD40 REPEAT PROTEIN WD REPEAT-CONTAINING PROTEIN 38 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=7808|UniProtKB=P01138 P01138 NGF PTHR11589:SF10 NERVE GROWTH FACTOR NGF -RELATED BETA-NERVE GROWTH FACTOR growth factor activity#GO:0008083;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;cell communication#GO:0007154;system development#GO:0048731;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of cellular process#GO:0050794;response to growth factor#GO:0070848;regulation of cell communication#GO:0010646;modulation of chemical synaptic transmission#GO:0050804;cellular response to stimulus#GO:0051716;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;negative regulation of cellular process#GO:0048523;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;multicellular organismal process#GO:0032501;negative regulation of apoptotic process#GO:0043066;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;neuron development#GO:0048666;cellular response to growth factor stimulus#GO:0071363;animal gross anatomical part developmental process#GO:0160108;regulation of signaling#GO:0023051;generation of neurons#GO:0048699;cell morphogenesis#GO:0000902;cellular response to endogenous stimulus#GO:0071495;cell projection organization#GO:0030030;cell differentiation#GO:0030154;response to stimulus#GO:0050896;cell development#GO:0048468;signaling#GO:0023052;cellular component organization#GO:0016043;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;cellular response to nerve growth factor stimulus#GO:1990090;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cell projection morphogenesis#GO:0048858;plasma membrane bounded cell projection morphogenesis#GO:0120039;regulation of apoptotic process#GO:0042981;cell surface receptor signaling pathway#GO:0007166;neuron differentiation#GO:0030182;regulation of trans-synaptic signaling#GO:0099177;nervous system development#GO:0007399;negative regulation of neuron apoptotic process#GO:0043524;regulation of neuron apoptotic process#GO:0043523;neuron projection development#GO:0031175;cellular process#GO:0009987;signal transduction#GO:0007165;negative regulation of programmed cell death#GO:0043069 cell junction#GO:0030054;secretory vesicle#GO:0099503;presynapse#GO:0098793;endomembrane system#GO:0012505;transport vesicle#GO:0030133;cytoplasm#GO:0005737;extracellular region#GO:0005576;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;intracellular vesicle#GO:0097708;synaptic vesicle#GO:0008021;vesicle#GO:0031982;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 neurotrophic factor#PC00163;growth factor#PC00112 HUMAN|HGNC=26313|UniProtKB=Q499Z3 Q499Z3 SLFNL1 PTHR12155:SF29 SCHLAFEN SCHLAFEN-LIKE PROTEIN 1 endoribonuclease#PC00094 HUMAN|HGNC=28480|UniProtKB=Q8TBE7 Q8TBE7 SLC35G2 PTHR22911:SF52 ACYL-MALONYL CONDENSING ENZYME-RELATED SOLUTE CARRIER FAMILY 35 MEMBER G2 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227 HUMAN|HGNC=5977|UniProtKB=P40933 P40933 IL15 PTHR14356:SF3 INTERLEUKIN-15-RELATED INTERLEUKIN-15 signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;cytokine activity#GO:0005125;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 positive regulation of leukocyte cell-cell adhesion#GO:1903039;biological regulation#GO:0065007;positive regulation of cell activation#GO:0050867;positive regulation of response to stimulus#GO:0048584;regulation of lymphocyte proliferation#GO:0050670;multicellular organismal process#GO:0032501;regulation of cell adhesion#GO:0030155;positive regulation of cellular process#GO:0048522;regulation of cytokine production#GO:0001817;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;regulation of leukocyte cell-cell adhesion#GO:1903037;positive regulation of leukocyte proliferation#GO:0070665;regulation of macromolecule metabolic process#GO:0060255;regulation of T cell proliferation#GO:0042129;regulation of immune system process#GO:0002682;regulation of cell-cell adhesion#GO:0022407;positive regulation of cytokine production#GO:0001819;regulation of cellular process#GO:0050794;positive regulation of cell adhesion#GO:0045785;leukocyte activation#GO:0045321;positive regulation of lymphocyte activation#GO:0051251;positive regulation of biosynthetic process#GO:0009891;regulation of cell population proliferation#GO:0042127;positive regulation of lymphocyte proliferation#GO:0050671;regulation of immune response#GO:0050776;cell activation#GO:0001775;regulation of multicellular organismal process#GO:0051239;positive regulation of T cell activation#GO:0050870;positive regulation of macromolecule metabolic process#GO:0010604;myeloid leukocyte activation#GO:0002274;regulation of T cell activation#GO:0050863;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of cell-cell adhesion#GO:0022409;positive regulation of immune system process#GO:0002684;regulation of mononuclear cell proliferation#GO:0032944;regulation of leukocyte proliferation#GO:0070663;positive regulation of mononuclear cell proliferation#GO:0032946;positive regulation of leukocyte activation#GO:0002696;positive regulation of T cell proliferation#GO:0042102;regulation of lymphocyte activation#GO:0051249;regulation of biological process#GO:0050789;regulation of cell activation#GO:0050865;positive regulation of multicellular organismal process#GO:0051240;positive regulation of cell population proliferation#GO:0008284;regulation of leukocyte activation#GO:0002694;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;immune system process#GO:0002376 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 interleukin superfamily#PC00128;cytokine#PC00083;intercellular signal molecule#PC00207 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>IL2#P00870;Interleukin signaling pathway#P00036>Interleukin#P00970 HUMAN|HGNC=12989|UniProtKB=Q9UBW7 Q9UBW7 ZMYM2 PTHR45736:SF6 ZINC FINGER MYM-TYPE PROTEIN ZINC FINGER MYM-TYPE PROTEIN 2 zinc finger transcription factor#PC00244;DNA-binding transcription factor#PC00218 HUMAN|HGNC=2535|UniProtKB=P09668 P09668 CTSH PTHR12411:SF1044 CYSTEINE PROTEASE FAMILY C1-RELATED PRO-CATHEPSIN H peptidase activator activity#GO:0016504;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;enzyme activator activity#GO:0008047;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;cysteine-type endopeptidase activity#GO:0004197;molecular function regulator activity#GO:0098772;catalytic activity, acting on a protein#GO:0140096;peptidase regulator activity#GO:0061134;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;hydrolase activity#GO:0016787 proteolysis#GO:0006508;immune system process#GO:0002376;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;zymogen activation#GO:0031638;response to stimulus#GO:0050896;catabolic process#GO:0009056;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein processing#GO:0016485;immune response#GO:0006955;protein maturation#GO:0051604;gene expression#GO:0010467;adaptive immune response#GO:0002250;biosynthetic process#GO:0009058 organelle#GO:0043226;cellular anatomical structure#GO:0110165;vacuole#GO:0005773;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;extracellular region#GO:0005576;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;cysteine protease#PC00081;protease#PC00190 HUMAN|HGNC=31326|UniProtKB=Q8WWM7 Q8WWM7 ATXN2L PTHR12854:SF8 ATAXIN 2-RELATED ATAXIN-2-LIKE PROTEIN binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723 cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;cellular component assembly#GO:0022607;cytoplasmic stress granule assembly#GO:0034063;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840 cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;organelle#GO:0043226;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoplasmic stress granule#GO:0010494 RNA metabolism protein#PC00031 HUMAN|HGNC=7642|UniProtKB=Q99747 Q99747 NAPG PTHR13768:SF2 SOLUBLE NSF ATTACHMENT PROTEIN SNAP GAMMA-SOLUBLE NSF ATTACHMENT PROTEIN membrane traffic protein#PC00150 HUMAN|HGNC=8893|UniProtKB=P49763 P49763 PGF PTHR12025:SF9 VASCULAR ENDOTHELIAL GROWTH FACTOR PLACENTA GROWTH FACTOR protein binding#GO:0005515;molecular function activator activity#GO:0140677;signaling receptor binding#GO:0005102;cytokine receptor binding#GO:0005126;binding#GO:0005488;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;growth factor activity#GO:0008083;growth factor receptor binding#GO:0070851 signaling#GO:0023052;circulatory system development#GO:0072359;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;response to endogenous stimulus#GO:0009719;regulation of chemotaxis#GO:0050920;vascular endothelial growth factor receptor signaling pathway#GO:0048010;positive regulation of cell motility#GO:2000147;response to abiotic stimulus#GO:0009628;blood vessel morphogenesis#GO:0048514;cellular response to growth factor stimulus#GO:0071363;angiogenesis#GO:0001525;sprouting angiogenesis#GO:0002040;animal gross anatomical part developmental process#GO:0160108;regulation of response to external stimulus#GO:0032101;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of immune system process#GO:0002684;response to stress#GO:0006950;vasculature development#GO:0001944;anatomical structure formation involved in morphogenesis#GO:0048646;multicellular organism development#GO:0007275;positive regulation of response to external stimulus#GO:0032103;cell surface receptor signaling pathway#GO:0007166;response to growth factor#GO:0070848;regulation of leukocyte migration#GO:0002685;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;blood vessel development#GO:0001568;cellular response to stimulus#GO:0051716;tube morphogenesis#GO:0035239;response to oxygen levels#GO:0070482;response to decreased oxygen levels#GO:0036293;system development#GO:0048731;regulation of cell motility#GO:2000145;cell communication#GO:0007154;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of chemotaxis#GO:0050921;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;tube development#GO:0035295;positive regulation of response to stimulus#GO:0048584;multicellular organismal process#GO:0032501;positive regulation of cellular process#GO:0048522;positive regulation of cell migration#GO:0030335;response to hypoxia#GO:0001666;positive regulation of locomotion#GO:0040017;developmental process#GO:0032502;regulation of cell migration#GO:0030334;regulation of response to stimulus#GO:0048583 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207;growth factor#PC00112 HUMAN|HGNC=9255|UniProtKB=P23284 P23284 PPIB PTHR11071:SF477 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE B membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229 chaperone#PC00072 HUMAN|HGNC=9823|UniProtKB=O75771 O75771 RAD51D PTHR46457:SF1 DNA REPAIR PROTEIN RAD51 HOMOLOG 4 DNA REPAIR PROTEIN RAD51 HOMOLOG 4 nucleic acid binding#GO:0003676;binding#GO:0005488;ATP-dependent activity#GO:0140657;single-stranded DNA binding#GO:0003697;ATP-dependent activity, acting on DNA#GO:0008094;DNA binding#GO:0003677;four-way junction DNA binding#GO:0000400;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;catalytic activity, acting on DNA#GO:0140097 cellular process#GO:0009987;organelle organization#GO:0006996;response to stress#GO:0006950;DNA recombination#GO:0006310;metabolic process#GO:0008152;meiotic cell cycle#GO:0051321;DNA metabolic process#GO:0006259;double-strand break repair#GO:0006302;cellular component organization or biogenesis#GO:0071840;double-strand break repair via homologous recombination#GO:0000724;cell cycle process#GO:0022402;meiotic cell cycle process#GO:1903046;cellular component organization#GO:0016043;meiosis I#GO:0007127;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;reciprocal meiotic recombination#GO:0007131;nuclear division#GO:0000280;nucleobase-containing compound metabolic process#GO:0006139;DNA damage response#GO:0006974;DNA repair#GO:0006281;telomere maintenance#GO:0000723;chromosome organization#GO:0051276;macromolecule metabolic process#GO:0043170;meiotic nuclear division#GO:0140013;reciprocal homologous recombination#GO:0140527;cellular response to stimulus#GO:0051716;cell cycle#GO:0007049;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;homologous recombination#GO:0035825;reproductive process#GO:0022414;sexual reproduction#GO:0019953;meiosis I cell cycle process#GO:0061982;recombinational repair#GO:0000725;telomere organization#GO:0032200;organelle fission#GO:0048285 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;replication fork#GO:0005657;chromosome#GO:0005694;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815 DNA metabolism protein#PC00009 HUMAN|HGNC=9677|UniProtKB=Q92932 Q92932 PTPRN2 PTHR46106:SF5 IA-2 PROTEIN TYROSINE PHOSPHATASE, ISOFORM C RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE N2 transport#GO:0006810;establishment of protein localization to extracellular region#GO:0035592;cellular homeostasis#GO:0019725;intracellular protein localization#GO:0008104;intracellular chemical homeostasis#GO:0055082;establishment of localization#GO:0051234;nitrogen compound transport#GO:0071705;peptide transport#GO:0015833;macromolecule localization#GO:0033036;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;response to glucose#GO:0009749;insulin secretion#GO:0030073;peptide secretion#GO:0002790;signal release#GO:0023061;peptide hormone secretion#GO:0030072;secretion#GO:0046903;localization#GO:0051179;regulation of secretion#GO:0051046;cell communication#GO:0007154;protein localization to extracellular region#GO:0071692;cellular response to stimulus#GO:0051716;homeostatic process#GO:0042592;chemical homeostasis#GO:0048878;hormone transport#GO:0009914;cellular response to glucose stimulus#GO:0071333;regulation of localization#GO:0032879;regulation of transport#GO:0051049;glucose homeostasis#GO:0042593;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;response to chemical#GO:0042221;response to oxygen-containing compound#GO:1901700;response to monosaccharide#GO:0034284;cellular response to chemical stimulus#GO:0070887;regulation of biological quality#GO:0065008;protein transport#GO:0015031;hormone secretion#GO:0046879;response to carbohydrate#GO:0009743;intracellular glucose homeostasis#GO:0001678;secretion by cell#GO:0032940;cellular localization#GO:0051641;protein secretion#GO:0009306;regulation of hormone levels#GO:0010817;carbohydrate homeostasis#GO:0033500;regulation of biological process#GO:0050789;response to hexose#GO:0009746;export from cell#GO:0140352;signaling#GO:0023052;response to stimulus#GO:0050896 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;synapse#GO:0045202;vesicle#GO:0031982;intracellular vesicle#GO:0097708;secretory vesicle#GO:0099503;membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;cell junction#GO:0030054;intracellular organelle#GO:0043229 protein phosphatase#PC00195 HUMAN|HGNC=32275|UniProtKB=Q7RTU0 Q7RTU0 TCF24 PTHR23349:SF48 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST TRANSCRIPTION FACTOR 24 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=18325|UniProtKB=Q2WGN9 Q2WGN9 GAB4 PTHR45960:SF4 GRB2-ASSOCIATED-BINDING PROTEIN GRB2-ASSOCIATED-BINDING PROTEIN 4 signaling adaptor activity#GO:0035591;protein binding#GO:0005515;enzyme binding#GO:0019899;transmembrane receptor protein tyrosine kinase adaptor activity#GO:0005068;protein kinase binding#GO:0019901;kinase binding#GO:0019900;binding#GO:0005488;signaling receptor binding#GO:0005102;protein tyrosine kinase binding#GO:1990782;protein-macromolecule adaptor activity#GO:0030674;receptor tyrosine kinase binding#GO:0030971;signaling receptor complex adaptor activity#GO:0030159;molecular adaptor activity#GO:0060090 cell communication#GO:0007154;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HUMAN|HGNC=12223|UniProtKB=A0A599 A0A599 TRBV5-6 PTHR23268:SF6 T-CELL RECEPTOR BETA CHAIN T CELL RECEPTOR BETA VARIABLE 5-5-RELATED cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=2442|UniProtKB=Q14406 Q14406 CSHL1 PTHR11417:SF67 SOMATOTROPIN,PROLACTIN CHORIONIC SOMATOMAMMOTROPIN HORMONE 1-RELATED protein binding#GO:0005515;hormone activity#GO:0005179;molecular function activator activity#GO:0140677;binding#GO:0005488;cytokine receptor binding#GO:0005126;signaling receptor binding#GO:0005102;hormone receptor binding#GO:0051427;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;signaling receptor regulator activity#GO:0030545;growth factor activity#GO:0008083;receptor ligand activity#GO:0048018 positive regulation of signaling#GO:0023056;response to oxygen-containing compound#GO:1901700;regulation of signaling#GO:0023051;cellular response to chemical stimulus#GO:0070887;animal gross anatomical part developmental process#GO:0160108;signaling#GO:0023052;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;cellular response to hormone stimulus#GO:0032870;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;animal organ development#GO:0048513;cell surface receptor signaling pathway#GO:0007166;response to chemical#GO:0042221;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;response to hormone#GO:0009725;response to nitrogen compound#GO:1901698;cell communication#GO:0007154;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of receptor signaling pathway via JAK-STAT#GO:0046427;cellular response to peptide hormone stimulus#GO:0071375;regulation of cell communication#GO:0010646;regulation of receptor signaling pathway via STAT#GO:1904892;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;developmental process#GO:0032502;regulation of receptor signaling pathway via JAK-STAT#GO:0046425;regulation of response to stimulus#GO:0048583;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;response to peptide hormone#GO:0043434;positive regulation of response to stimulus#GO:0048584;cellular response to nitrogen compound#GO:1901699;positive regulation of cellular process#GO:0048522;response to nutrient levels#GO:0031667 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 peptide hormone#PC00179 HUMAN|HGNC=24465|UniProtKB=Q9UL52 Q9UL52 TMPRSS11E PTHR24253:SF84 TRANSMEMBRANE PROTEASE SERINE TRANSMEMBRANE PROTEASE SERINE 11E serine-type peptidase activity#GO:0008236;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;serine hydrolase activity#GO:0017171 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein processing#GO:0016485;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467;proteolysis#GO:0006508;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 protein modifying enzyme#PC00260;protease#PC00190;serine protease#PC00203 HUMAN|HGNC=20609|UniProtKB=Q13155 Q13155 AIMP2 PTHR13438:SF2 AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN 2 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;protein-containing complex organization#GO:0043933;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987 catalytic complex#GO:1902494;protein-containing complex#GO:0032991;intracellular protein-containing complex#GO:0140535 scaffold/adaptor protein#PC00226 HUMAN|HGNC=13629|UniProtKB=Q96DU9 Q96DU9 PABPC5 PTHR24012:SF682 RNA BINDING PROTEIN POLYADENYLATE-BINDING PROTEIN 5 mRNA binding#GO:0003729;poly(A) binding#GO:0008143;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA 3'-UTR binding#GO:0003730;single-stranded RNA binding#GO:0003727;RNA binding#GO:0003723 post-transcriptional regulation of gene expression#GO:0010608;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;nucleus#GO:0005634;cytosol#GO:0005829;cytoplasmic stress granule#GO:0010494;membraneless organelle#GO:0043228;intracellular membrane-bounded organelle#GO:0043231;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904 RNA metabolism protein#PC00031 HUMAN|HGNC=4848|UniProtKB=O43613 O43613 HCRTR1 PTHR24241:SF30 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR OREXIN_HYPOCRETIN RECEPTOR TYPE 1 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023 cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;neuropeptide signaling pathway#GO:0007218;response to endogenous stimulus#GO:0009719;signaling#GO:0023052;cellular response to hormone stimulus#GO:0032870;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;cellular process#GO:0009987;signal transduction#GO:0007165;response to hormone#GO:0009725;biological regulation#GO:0065007;response to chemical#GO:0042221 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=30497|UniProtKB=Q2M1P5 Q2M1P5 KIF7 PTHR24115:SF445 KINESIN-RELATED KINESIN-LIKE PROTEIN KIF7 microtubule binding#GO:0008017;polypeptide conformation or assembly isomerase activity#GO:0120544;ATP hydrolysis activity#GO:0016887;microtubule motor activity#GO:0003777;hydrolase activity#GO:0016787;tubulin binding#GO:0015631;macromolecular conformation isomerase activity#GO:0120543;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;isomerase activity#GO:0016853;ribonucleoside triphosphate phosphatase activity#GO:0017111;ATP-dependent activity#GO:0140657;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;hydrolase activity, acting on acid anhydrides#GO:0016817;cytoskeletal motor activity#GO:0003774 microtubule-based process#GO:0007017;microtubule-based movement#GO:0007018;cellular process#GO:0009987 microtubule#GO:0005874;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cytoskeleton#GO:0005856;supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;microtubule associated complex#GO:0005875;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=1436|UniProtKB=P29377 P29377 S100G PTHR11639:SF73 S100 CALCIUM-BINDING PROTEIN PROTEIN S100-G metal ion binding#GO:0046872;protein binding#GO:0005515;cation binding#GO:0043169;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;calcium ion binding#GO:0005509 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;sarcoplasmic reticulum#GO:0016529;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;sarcoplasm#GO:0016528;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 calcium-binding protein#PC00060;calmodulin-related#PC00061 HUMAN|HGNC=17020|UniProtKB=Q9Y616 Q9Y616 IRAK3 PTHR24419:SF7 INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 3 histone kinase activity#GO:0035173;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;histone modifying activity#GO:0140993;protein serine/threonine kinase activity#GO:0004674 positive regulation of signaling#GO:0023056;response to peptide#GO:1901652;regulation of intracellular signal transduction#GO:1902531;cellular response to chemical stimulus#GO:0070887;regulation of signaling#GO:0023051;response to oxygen-containing compound#GO:1901700;response to stimulus#GO:0050896;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;response to molecule of bacterial origin#GO:0002237;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;positive regulation of canonical NF-kappaB signal transduction#GO:0043123;response to lipopolysaccharide#GO:0032496;cell surface receptor signaling pathway#GO:0007166;cellular response to lipid#GO:0071396;response to lipid#GO:0033993;response to chemical#GO:0042221;response to cytokine#GO:0034097;cellular response to lipopolysaccharide#GO:0071222;response to biotic stimulus#GO:0009607;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;lipopolysaccharide-mediated signaling pathway#GO:0031663;response to bacterium#GO:0009617;cytokine-mediated signaling pathway#GO:0019221;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;mitotic cell cycle#GO:0000278;regulation of cell communication#GO:0010646;response to external biotic stimulus#GO:0043207;cellular response to biotic stimulus#GO:0071216;positive regulation of signal transduction#GO:0009967;cell cycle#GO:0007049;cellular response to stimulus#GO:0051716;cellular response to molecule of bacterial origin#GO:0071219;response to external stimulus#GO:0009605;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of response to stimulus#GO:0048584;response to other organism#GO:0051707;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of canonical NF-kappaB signal transduction#GO:0043122;positive regulation of cellular process#GO:0048522 cell periphery#GO:0071944;nucleus#GO:0005634;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 non-receptor serine/threonine protein kinase#PC00167 Toll receptor signaling pathway#P00054>IRAKM#P01378 HUMAN|HGNC=15529|UniProtKB=Q8NFZ3 Q8NFZ3 NLGN4Y PTHR43903:SF10 NEUROLIGIN NEUROLIGIN-4, Y-LINKED postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;synaptic membrane#GO:0097060;cell junction#GO:0030054;postsynapse#GO:0098794;membrane#GO:0016020;cell periphery#GO:0071944;synapse#GO:0045202;cellular anatomical structure#GO:0110165;postsynaptic specialization#GO:0099572;organelle#GO:0043226;plasma membrane region#GO:0098590;plasma membrane#GO:0005886 cell adhesion molecule#PC00069 HUMAN|HGNC=26838|UniProtKB=Q495A1 Q495A1 TIGIT PTHR47734:SF1 T-CELL IMMUNORECEPTOR WITH IG AND ITIM DOMAINS PROTEIN, TIGIT T-CELL IMMUNORECEPTOR WITH IG AND ITIM DOMAINS protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 regulation of leukocyte activation#GO:0002694;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;positive regulation of multicellular organismal process#GO:0051240;regulation of cell activation#GO:0050865;negative regulation of metabolic process#GO:0009892;regulation of lymphocyte activation#GO:0051249;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;negative regulation of macromolecule biosynthetic process#GO:0010558;positive regulation of biological process#GO:0048518;negative regulation of cell-cell adhesion#GO:0022408;positive regulation of macromolecule metabolic process#GO:0010604;regulation of T cell activation#GO:0050863;negative regulation of leukocyte activation#GO:0002695;regulation of multicellular organismal process#GO:0051239;negative regulation of lymphocyte activation#GO:0051250;negative regulation of multicellular organismal process#GO:0051241;regulation of macromolecule metabolic process#GO:0060255;positive regulation of cytokine production#GO:0001819;regulation of cell-cell adhesion#GO:0022407;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;negative regulation of leukocyte cell-cell adhesion#GO:1903038;negative regulation of T cell activation#GO:0050868;positive regulation of biosynthetic process#GO:0009891;regulation of cytokine production#GO:0001817;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;negative regulation of cell adhesion#GO:0007162;regulation of cell adhesion#GO:0030155;negative regulation of biosynthetic process#GO:0009890;negative regulation of immune system process#GO:0002683;biological regulation#GO:0065007;regulation of leukocyte cell-cell adhesion#GO:1903037;negative regulation of cellular process#GO:0048523;negative regulation of cell activation#GO:0050866;regulation of biosynthetic process#GO:0009889;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468 cell surface#GO:0009986;cellular anatomical structure#GO:0110165 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=24859|UniProtKB=O95619 O95619 YEATS4 PTHR23195:SF15 YEATS DOMAIN YEATS DOMAIN-CONTAINING PROTEIN 4 protein binding#GO:0005515;binding#GO:0005488;histone binding#GO:0042393 regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;chromatin remodeling#GO:0006338;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;chromatin organization#GO:0006325;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 nucleus#GO:0005634;chromatin#GO:0000785;H4 histone acetyltransferase complex#GO:1902562;protein-containing complex#GO:0032991;NuA4 histone acetyltransferase complex#GO:0035267;intracellular membraneless organelle#GO:0043232;transferase complex#GO:1990234;membraneless organelle#GO:0043228;intracellular protein-containing complex#GO:0140535;histone acetyltransferase complex#GO:0000123;chromosome#GO:0005694;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;protein acetyltransferase complex#GO:0031248;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;acetyltransferase complex#GO:1902493 general transcription factor#PC00259 HUMAN|HGNC=15025|UniProtKB=Q8NGZ2 Q8NGZ2 OR14K1 PTHR26452:SF388 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 14K1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 sensory perception#GO:0007600;nervous system process#GO:0050877;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=9671|UniProtKB=P23470 P23470 PTPRG PTHR19134:SF468 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE GAMMA phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 signal transduction#GO:0007165;cellular process#GO:0009987;neuron projection development#GO:0031175;biological regulation#GO:0065007;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;multicellular organismal process#GO:0032501;neuron differentiation#GO:0030182;developmental process#GO:0032502;neurogenesis#GO:0022008;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular component organization#GO:0016043;signaling#GO:0023052;cell development#GO:0048468;cell projection organization#GO:0030030;response to stimulus#GO:0050896;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;neuron development#GO:0048666;cell communication#GO:0007154;anatomical structure development#GO:0048856 protein modifying enzyme#PC00260;protein phosphatase#PC00195 HUMAN|HGNC=31401|UniProtKB=Q4G0N8 Q4G0N8 SLC9C1 PTHR10110:SF87 SODIUM/HYDROGEN EXCHANGER SOLUTE CARRIER FAMILY 9 MEMBER C1 proton transmembrane transporter activity#GO:0015078;antiporter activity#GO:0015297;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;metal cation:proton antiporter activity#GO:0051139;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324 homeostatic process#GO:0042592;metal ion transport#GO:0030001;inorganic ion import across plasma membrane#GO:0099587;import across plasma membrane#GO:0098739;sodium ion transport#GO:0006814;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;regulation of intracellular pH#GO:0051453;regulation of pH#GO:0006885;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;inorganic cation import across plasma membrane#GO:0098659;establishment of localization#GO:0051234;import into cell#GO:0098657;intracellular monoatomic cation homeostasis#GO:0030003;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 secondary carrier transporter#PC00258 HUMAN|HGNC=21789|UniProtKB=Q9UG22 Q9UG22 GIMAP2 PTHR10903:SF7 GTPASE, IMAP FAMILY MEMBER-RELATED GTPASE IMAP FAMILY MEMBER 2 hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 small GTPase#PC00208 HUMAN|HGNC=4430|UniProtKB=O95249 O95249 GOSR1 PTHR21094:SF2 GOS-28 SNARE- RELATED GOLGI SNAP RECEPTOR COMPLEX MEMBER 1 SNAP receptor activity#GO:0005484;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 organelle membrane fusion#GO:0090174;membrane organization#GO:0061024;vesicle-mediated transport#GO:0016192;organelle fusion#GO:0048284;cellular process#GO:0009987;organelle organization#GO:0006996;membrane fusion#GO:0061025;vesicle organization#GO:0016050;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;Golgi vesicle transport#GO:0048193;transport#GO:0006810;vesicle fusion#GO:0006906;intra-Golgi vesicle-mediated transport#GO:0006891;cellular component organization#GO:0016043;localization#GO:0051179 Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;Golgi cisterna#GO:0031985;cytoplasm#GO:0005737;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane protein complex#GO:0098796;Golgi stack#GO:0005795;cellular anatomical structure#GO:0110165;SNARE complex#GO:0031201;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227 SNARE protein#PC00034;membrane traffic protein#PC00150 HUMAN|HGNC=29039|UniProtKB=Q5VT52 Q5VT52 RPRD2 PTHR12460:SF40 CYCLIN-DEPENDENT KINASE INHIBITOR-RELATED PROTEIN REGULATION OF NUCLEAR PRE-MRNA DOMAIN-CONTAINING PROTEIN 2 binding#GO:0005488;enzyme binding#GO:0019899;RNA polymerase binding#GO:0070063;RNA polymerase II complex binding#GO:0000993;protein binding#GO:0005515;RNA polymerase core enzyme binding#GO:0043175 nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;mRNA 3'-end processing#GO:0031124;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058 kinase inhibitor#PC00139;protein-binding activity modulator#PC00095 HUMAN|HGNC=25744|UniProtKB=Q9H9L7 Q9H9L7 AKIRIN1 PTHR13293:SF9 AKIRIN-RELATED AKIRIN-1 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 growth#GO:0040007;positive regulation of cell differentiation#GO:0045597;regeneration#GO:0031099;positive regulation of cellular component biogenesis#GO:0044089;regulation of response to external stimulus#GO:0032101;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of immune system process#GO:0002684;positive regulation of macromolecule biosynthetic process#GO:0010557;tissue regeneration#GO:0042246;animal gross anatomical part developmental process#GO:0160108;regulation of cellular component biogenesis#GO:0044087;regulation of cellular component organization#GO:0051128;regulation of transcription by RNA polymerase II#GO:0006357;regulation of plasma membrane bounded cell projection assembly#GO:0120032;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of chemotaxis#GO:0050920;positive regulation of response to biotic stimulus#GO:0002833;positive regulation of locomotion#GO:0040017;regulation of biosynthetic process#GO:0009889;developmental growth#GO:0048589;regulation of innate immune response#GO:0045088;regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of cell differentiation#GO:0045595;regulation of response to stimulus#GO:0048583;positive regulation of developmental process#GO:0051094;positive regulation of defense response#GO:0031349;positive regulation of immune response#GO:0050778;regulation of cell migration#GO:0030334;negative regulation of cellular process#GO:0048523;regulation of cell projection organization#GO:0031344;regulation of locomotion#GO:0040012;biological regulation#GO:0065007;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of response to stimulus#GO:0048584;positive regulation of cell migration#GO:0030335;positive regulation of cellular process#GO:0048522;negative regulation of cell population proliferation#GO:0008285;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;anatomical structure development#GO:0048856;regulation of cell population proliferation#GO:0042127;regulation of defense response#GO:0031347;positive regulation of cell projection organization#GO:0031346;regulation of immune response#GO:0050776;positive regulation of RNA metabolic process#GO:0051254;cell motility#GO:0048870;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of response to external stimulus#GO:0032103;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of metabolic process#GO:0009893;positive regulation of cellular component organization#GO:0051130;positive regulation of cell motility#GO:2000147;regulation of gene expression#GO:0010468;developmental process#GO:0032502;regulation of response to stress#GO:0080134;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;cell migration#GO:0016477;positive regulation of innate immune response#GO:0045089;regulation of macromolecule biosynthetic process#GO:0010556;regulation of cell projection assembly#GO:0060491;regulation of DNA-templated transcription#GO:0006355;positive regulation of chemotaxis#GO:0050921;regulation of cell motility#GO:2000145;positive regulation of biosynthetic process#GO:0009891;regulation of granulocyte chemotaxis#GO:0071622;regulation of response to biotic stimulus#GO:0002831;regulation of developmental process#GO:0050793;regulation of leukocyte migration#GO:0002685 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=1816|UniProtKB=O75871 O75871 CEACAM4 PTHR44427:SF8 CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 19 CELL ADHESION MOLECULE CEACAM4 protein binding#GO:0005515;protein tyrosine kinase binding#GO:1990782;kinase binding#GO:0019900;binding#GO:0005488;enzyme binding#GO:0019899;protein kinase binding#GO:0019901 cell communication#GO:0007154;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;biological regulation#GO:0065007;signaling#GO:0023052 cellular anatomical structure#GO:0110165;cell surface#GO:0009986;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 cell adhesion molecule#PC00069 HUMAN|HGNC=3229|UniProtKB=P01133 P01133 EGF PTHR46513:SF5 VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED PRO-EPIDERMAL GROWTH FACTOR signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;growth factor activity#GO:0008083;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546 cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of signaling#GO:0023056;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;positive regulation of cell population proliferation#GO:0008284;signaling#GO:0023052;regulation of cell communication#GO:0010646;response to stimulus#GO:0050896;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;positive regulation of intracellular signal transduction#GO:1902533;regulation of MAPK cascade#GO:0043408;regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166;positive regulation of MAPK cascade#GO:0043410;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165;ERBB signaling pathway#GO:0038127;cellular process#GO:0009987;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of response to stimulus#GO:0048584;epidermal growth factor receptor signaling pathway#GO:0007173 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 EGF receptor signaling pathway#P00018>EGF#P00549;Gonadotropin-releasing hormone receptor pathway#P06664>EGF#P06745 HUMAN|HGNC=3631|UniProtKB=P14324 P14324 FDPS PTHR11525:SF23 FARNESYL-PYROPHOSPHATE SYNTHETASE FARNESYL PYROPHOSPHATE SYNTHASE prenyltransferase activity#GO:0004659;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;transferase activity#GO:0016740;catalytic activity#GO:0003824 isoprenoid metabolic process#GO:0006720;organophosphate biosynthetic process#GO:0090407;terpenoid metabolic process#GO:0006721;lipid metabolic process#GO:0006629;isoprenoid biosynthetic process#GO:0008299;metabolic process#GO:0008152;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;phospholipid biosynthetic process#GO:0008654;terpenoid biosynthetic process#GO:0016114;lipid biosynthetic process#GO:0008610;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 transferase#PC00220;acyltransferase#PC00042 Cholesterol biosynthesis#P00014>Geranyl trans-transferase#P00493 HUMAN|HGNC=13411|UniProtKB=Q8N3S3 Q8N3S3 PHTF2 PTHR12680:SF2 PUTATIVE HOMEODOMAIN TRANSCRIPTION FACTOR PHTF PROTEIN PHTF2 homeodomain transcription factor#PC00119 HUMAN|HGNC=25987|UniProtKB=Q9NXF7 Q9NXF7 DCAF16 PTHR16194:SF0 DDB1- AND CUL4-ASSOCIATED FACTOR 16 DDB1- AND CUL4-ASSOCIATED FACTOR 16 Cul4-RING E3 ubiquitin ligase complex#GO:0080008;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991 HUMAN|HGNC=19090|UniProtKB=Q9HAK2 Q9HAK2 EBF2 PTHR10747:SF33 TRANSCRIPTION FACTOR COE FAMILY MEMBER TRANSCRIPTION FACTOR COE2 binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 DNA-binding transcription factor#PC00218;P53-like transcription factor#PC00253 HUMAN|HGNC=5908|UniProtKB=P01717 P01717 IGLV3-25 PTHR23267:SF483 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN LAMBDA VARIABLE 3-25 response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 protein-containing complex#GO:0032991 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=34451|UniProtKB=Q6P0A1 Q6P0A1 FAM180B PTHR34034:SF1 PROTEIN FAM180A-RELATED PROTEIN FAM180B HUMAN|HGNC=6076|UniProtKB=Q14642 Q14642 INPP5A PTHR12997:SF2 TYPE I INOSITOL-1,4,5-TRISPHOSPHATE 5-PHOSPHATASE INOSITOL POLYPHOSPHATE-5-PHOSPHATASE A phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824 phosphatase#PC00181;hydrolase#PC00121 PI3 kinase pathway#P00048>SHIP#P01200 HUMAN|HGNC=10702|UniProtKB=Q15437 Q15437 SEC23B PTHR11141:SF10 PROTEIN TRANSPORT PROTEIN SEC23 PROTEIN TRANSPORT PROTEIN SEC23B molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047 COPII-coated vesicle budding#GO:0090114;cellular localization#GO:0051641;localization#GO:0051179;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular component organization#GO:0016043;intracellular transport#GO:0046907;transport#GO:0006810;Golgi vesicle transport#GO:0048193;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;vesicle budding from membrane#GO:0006900;vesicle organization#GO:0016050;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;membrane organization#GO:0061024 vesicle#GO:0031982;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;coated vesicle membrane#GO:0030662;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;coated vesicle#GO:0030135;intracellular anatomical structure#GO:0005622;coated membrane#GO:0048475;COPII-coated ER to Golgi transport vesicle#GO:0030134;membrane coat#GO:0030117;vesicle membrane#GO:0012506;membrane#GO:0016020;vesicle coat#GO:0030120;cytoplasm#GO:0005737;transport vesicle#GO:0030133;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;transport vesicle membrane#GO:0030658;ER to Golgi transport vesicle membrane#GO:0012507;endoplasmic reticulum#GO:0005783;endoplasmic reticulum exit site#GO:0070971;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090 vesicle coat protein#PC00235;membrane traffic protein#PC00150 HUMAN|HGNC=25303|UniProtKB=Q6NSX1 Q6NSX1 CCDC70 PTHR21533:SF22 LEUCINE-RICH PROTEIN COILED-COIL DOMAIN-CONTAINING PROTEIN 70 HUMAN|HGNC=14892|UniProtKB=Q9UHL4 Q9UHL4 DPP7 PTHR11010:SF107 PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED DIPEPTIDYL PEPTIDASE 2 macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;cellular process#GO:0009987;catabolic process#GO:0009056 intracellular organelle#GO:0043229;lytic vacuole#GO:0000323;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;vesicle#GO:0031982;lysosome#GO:0005764;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vacuole#GO:0005773;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 serine protease#PC00203 HUMAN|HGNC=20749|UniProtKB=Q5W0Z9 Q5W0Z9 ZDHHC20 PTHR22883:SF417 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE ZDHHC20 catalytic activity, acting on a protein#GO:0140096;palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824 organelle organization#GO:0006996;establishment of protein localization to membrane#GO:0090150;cellular process#GO:0009987;establishment of protein localization#GO:0045184;developmental maturation#GO:0021700;protein targeting to membrane#GO:0006612;developmental process#GO:0032502;establishment of localization#GO:0051234;synaptic vesicle maturation#GO:0016188;cellular component organization or biogenesis#GO:0071840;vesicle organization#GO:0016050;cellular component organization#GO:0016043;protein targeting#GO:0006605;localization within membrane#GO:0051668;cellular localization#GO:0051641;localization#GO:0051179 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 protein modifying enzyme#PC00260 HUMAN|HGNC=12128|UniProtKB=A0A0B4J244 A0A0B4J244 TRAV3 PTHR19367:SF8 T-CELL RECEPTOR ALPHA CHAIN V REGION T CELL RECEPTOR ALPHA VARIABLE 3 immune system process#GO:0002376;immune response#GO:0006955;response to stimulus#GO:0050896;adaptive immune response#GO:0002250 protein-containing complex#GO:0032991 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=2299|UniProtKB=P15086 P15086 CPB1 PTHR11705:SF20 PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B CARBOXYPEPTIDASE B metalloexopeptidase activity#GO:0008235;catalytic activity#GO:0003824;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;metallopeptidase activity#GO:0008237;carboxypeptidase activity#GO:0004180;hydrolase activity#GO:0016787;metallocarboxypeptidase activity#GO:0004181;exopeptidase activity#GO:0008238 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;metabolic process#GO:0008152;proteolysis#GO:0006508;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 metalloprotease#PC00153 HUMAN|HGNC=1609|UniProtKB=P51685 P51685 CCR8 PTHR10489:SF627 CELL ADHESION MOLECULE C-C CHEMOKINE RECEPTOR TYPE 8 signaling receptor activity#GO:0038023;cytokine binding#GO:0019955;G protein-coupled receptor activity#GO:0004930;immune receptor activity#GO:0140375;cytokine receptor activity#GO:0004896;molecular transducer activity#GO:0060089;protein binding#GO:0005515;transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488 regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;signaling#GO:0023052;locomotion#GO:0040011;response to stimulus#GO:0050896;cell motility#GO:0048870;regulation of cellular process#GO:0050794;chemotaxis#GO:0006935;cellular response to chemical stimulus#GO:0070887;positive regulation of cytosolic calcium ion concentration#GO:0007204;immune system process#GO:0002376;cell chemotaxis#GO:0060326;intracellular signal transduction#GO:0035556;regulation of biological quality#GO:0065008;cell communication#GO:0007154;signal transduction#GO:0007165;immune response#GO:0006955;cellular process#GO:0009987;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124;taxis#GO:0042330;response to chemical#GO:0042221;cell migration#GO:0016477;response to external stimulus#GO:0009605;calcium-mediated signaling#GO:0019722 membrane#GO:0016020;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;plasma membrane#GO:0005886 cell adhesion molecule#PC00069 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CHKR#P00854 HUMAN|HGNC=26078|UniProtKB=Q8N0Z9 Q8N0Z9 VSIG10 PTHR11640:SF157 NEPHRIN V-SET AND IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN 10 binding#GO:0005488;cell adhesion molecule binding#GO:0050839;protein binding#GO:0005515 cellular process#GO:0009987;cell adhesion#GO:0007155;cell-cell adhesion#GO:0098609 cell junction#GO:0030054;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;anchoring junction#GO:0070161;cell-cell junction#GO:0005911;membrane#GO:0016020;cell periphery#GO:0071944 immunoglobulin superfamily cell adhesion molecule#PC00125;cell adhesion molecule#PC00069 HUMAN|HGNC=8876|UniProtKB=P17858 P17858 PFKL PTHR13697:SF14 PHOSPHOFRUCTOKINASE ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE, LIVER TYPE carbohydrate kinase activity#GO:0019200;carbohydrate derivative binding#GO:0097367;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;ion binding#GO:0043167;anion binding#GO:0043168;binding#GO:0005488;small molecule binding#GO:0036094;phosphotransferase activity, alcohol group as acceptor#GO:0016773 glucose metabolic process#GO:0006006;purine-containing compound catabolic process#GO:0072523;purine nucleoside diphosphate catabolic process#GO:0009137;nucleobase-containing small molecule metabolic process#GO:0055086;monosaccharide metabolic process#GO:0005996;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;ADP catabolic process#GO:0046032;ribose phosphate metabolic process#GO:0019693;ATP metabolic process#GO:0046034;cellular process#GO:0009987;nicotinamide nucleotide metabolic process#GO:0046496;carbohydrate catabolic process#GO:0016052;nucleotide metabolic process#GO:0009117;ribonucleotide metabolic process#GO:0009259;purine nucleoside diphosphate metabolic process#GO:0009135;oxoacid metabolic process#GO:0043436;small molecule metabolic process#GO:0044281;small molecule catabolic process#GO:0044282;pyruvate metabolic process#GO:0006090;pyridine nucleotide catabolic process#GO:0019364;carboxylic acid metabolic process#GO:0019752;phosphorus metabolic process#GO:0006793;monocarboxylic acid metabolic process#GO:0032787;purine-containing compound metabolic process#GO:0072521;ribonucleoside diphosphate metabolic process#GO:0009185;pyridine-containing compound catabolic process#GO:0072526;purine nucleotide metabolic process#GO:0006163;energy derivation by oxidation of organic compounds#GO:0015980;ADP metabolic process#GO:0046031;nucleotide catabolic process#GO:0009166;purine ribonucleoside diphosphate metabolic process#GO:0009179;generation of precursor metabolites and energy#GO:0006091;nucleobase-containing compound metabolic process#GO:0006139;organophosphate metabolic process#GO:0019637;nucleobase-containing compound catabolic process#GO:0034655;glycolytic process#GO:0006096;purine ribonucleoside triphosphate metabolic process#GO:0009205;carbohydrate derivative metabolic process#GO:1901135;ribonucleotide catabolic process#GO:0009261;cellular respiration#GO:0045333;organophosphate catabolic process#GO:0046434;ribonucleoside diphosphate catabolic process#GO:0009191;purine ribonucleoside diphosphate catabolic process#GO:0009181;aerobic respiration#GO:0009060;nucleoside diphosphate metabolic process#GO:0009132;pyridine-containing compound metabolic process#GO:0072524;purine nucleotide catabolic process#GO:0006195;nucleoside phosphate catabolic process#GO:1901292;catabolic process#GO:0009056;nucleoside phosphate metabolic process#GO:0006753;carbohydrate derivative catabolic process#GO:1901136;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate metabolic process#GO:0005975;primary metabolic process#GO:0044238;hexose metabolic process#GO:0019318;nucleoside diphosphate catabolic process#GO:0009134;purine nucleoside triphosphate metabolic process#GO:0009144;purine ribonucleotide catabolic process#GO:0009154 cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;membrane#GO:0016020;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;transferase complex#GO:1990234;transferase complex, transferring phosphorus-containing groups#GO:0061695 transferase#PC00220;carbohydrate kinase#PC00065;kinase#PC00137 Glycolysis#P00024>Phosphofructokinase-1#P00672 HUMAN|HGNC=4989|UniProtKB=O00479 O00479 HMGN4 PTHR23087:SF31 NONHISTONE CHROMOSOMAL PROTEIN HMG HIGH MOBILITY GROUP NUCLEOSOME-BINDING DOMAIN-CONTAINING PROTEIN 4 chromatin binding#GO:0003682;binding#GO:0005488 cellular process#GO:0009987;cellular component organization#GO:0016043;chromatin organization#GO:0006325;cellular component organization or biogenesis#GO:0071840 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=12840|UniProtKB=P54577 P54577 YARS1 PTHR11586:SF43 TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER TYROSINE--TRNA LIGASE, CYTOPLASMIC catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;ligase activity#GO:0016874;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098 tRNA aminoacylation#GO:0043039;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;tRNA aminoacylation for protein translation#GO:0006418;gene expression#GO:0010467;amino acid metabolic process#GO:0006520;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;amino acid activation#GO:0043038;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;protein biosynthetic process#GO:0160307;translation#GO:0006412;RNA metabolic process#GO:0016070;protein metabolic process#GO:0019538 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 translational protein#PC00263 HUMAN|HGNC=7692|UniProtKB=P51970 P51970 NDUFA8 PTHR13344:SF0 NADH-UBIQUINONE OXIDOREDUCTASE NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 8 respiratory chain complex#GO:0098803;membrane#GO:0016020;oxidoreductase complex#GO:1990204;membrane protein complex#GO:0098796;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;respiratory chain complex I#GO:0045271;catalytic complex#GO:1902494;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HUMAN|HGNC=10854|UniProtKB=O60902 O60902 SHOX2 PTHR46255:SF1 SHORT STATURE HOMEOBOX SHORT STATURE HOMEOBOX PROTEIN 2 transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 homeodomain transcription factor#PC00119 HUMAN|HGNC=18599|UniProtKB=Q9BSJ2 Q9BSJ2 TUBGCP2 PTHR19302:SF13 GAMMA TUBULIN COMPLEX PROTEIN GAMMA-TUBULIN COMPLEX COMPONENT 2 protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;microtubule binding#GO:0008017;binding#GO:0005488 chromosome segregation#GO:0007059;meiotic cell cycle#GO:0051321;microtubule-based process#GO:0007017;protein-containing complex organization#GO:0043933;microtubule polymerization#GO:0046785;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;spindle assembly#GO:0051225;microtubule polymerization or depolymerization#GO:0031109;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;sexual reproduction#GO:0019953;organelle assembly#GO:0070925;supramolecular fiber organization#GO:0097435;microtubule cytoskeleton organization#GO:0000226;cell cycle process#GO:0022402;protein polymerization#GO:0051258;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;microtubule nucleation#GO:0007020;cell cycle#GO:0007049;reproductive process#GO:0022414;cytoplasmic microtubule organization#GO:0031122;mitotic cell cycle#GO:0000278 intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HUMAN|HGNC=25535|UniProtKB=Q9NVV0 Q9NVV0 TMEM38B PTHR12454:SF5 TRIMERIC INTRACELLULAR CATION CHANNEL TRIMERIC INTRACELLULAR CATION CHANNEL TYPE B potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;potassium channel activity#GO:0005267;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261;metal ion transmembrane transporter activity#GO:0046873;passive transmembrane transporter activity#GO:0022803;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;metal ion transport#GO:0030001;calcium ion transmembrane transport#GO:0070588;calcium ion transport#GO:0006816;establishment of localization#GO:0051234;calcium ion transmembrane import into cytosol#GO:0097553;transport#GO:0006810;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;release of sequestered calcium ion into cytosol by sarcoplasmic reticulum#GO:0014808;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813;cellular process#GO:0009987;release of sequestered calcium ion into cytosol#GO:0051209 endomembrane system#GO:0012505;sarcoplasmic reticulum membrane#GO:0033017;cytoplasm#GO:0005737;membrane#GO:0016020;sarcoplasmic reticulum#GO:0016529;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;sarcoplasm#GO:0016528;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229 ion channel#PC00133;transporter#PC00227 HUMAN|HGNC=25284|UniProtKB=Q494U1 Q494U1 PLEKHN1 PTHR46882:SF1 PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY N MEMBER 1 PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY N MEMBER 1 phosphatidylinositol phosphate binding#GO:1901981;phospholipid binding#GO:0005543;phosphatidylserine binding#GO:0001786;lipid binding#GO:0008289;binding#GO:0005488;anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167 regulation of RNA stability#GO:0043487;regulation of RNA metabolic process#GO:0051252;response to oxygen levels#GO:0070482;response to decreased oxygen levels#GO:0036293;positive regulation of mRNA catabolic process#GO:0061014;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;positive regulation of catabolic process#GO:0009896;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;response to hypoxia#GO:0001666;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;positive regulation of metabolic process#GO:0009893;regulation of biological quality#GO:0065008;negative regulation of gene expression#GO:0010629;response to abiotic stimulus#GO:0009628;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;regulation of biological process#GO:0050789;positive regulation of programmed cell death#GO:0043068;response to stimulus#GO:0050896;regulation of mRNA stability#GO:0043488;negative regulation of metabolic process#GO:0009892;positive regulation of mRNA metabolic process#GO:1903313;mRNA destabilization#GO:0061157;regulation of apoptotic process#GO:0042981;regulation of mRNA metabolic process#GO:1903311;positive regulation of apoptotic process#GO:0043065;response to stress#GO:0006950;RNA destabilization#GO:0050779;negative regulation of macromolecule biosynthetic process#GO:0010558;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604 cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;membrane#GO:0016020;organelle membrane#GO:0031090;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;organelle envelope#GO:0031967;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HUMAN|HGNC=1699|UniProtKB=P40259 P40259 CD79B PTHR14334:SF2 B-CELL ANTIGEN RECEPTOR COMPLEX-ASSOCIATED PROTEIN B-CELL ANTIGEN RECEPTOR COMPLEX-ASSOCIATED PROTEIN BETA CHAIN transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;signal transduction#GO:0007165;B cell receptor signaling pathway#GO:0050853;cellular process#GO:0009987;positive regulation of immune system process#GO:0002684;antigen receptor-mediated signaling pathway#GO:0050851;lymphocyte activation#GO:0046649;cell surface receptor signaling pathway#GO:0007166;B cell activation#GO:0042113;immune response-activating signaling pathway#GO:0002757;regulation of biological process#GO:0050789;immune response-regulating signaling pathway#GO:0002764;mononuclear cell differentiation#GO:1903131;leukocyte differentiation#GO:0002521;signaling#GO:0023052;cell development#GO:0048468;cell differentiation#GO:0030154;response to stimulus#GO:0050896;immune system process#GO:0002376;hemopoiesis#GO:0030097;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;positive regulation of response to stimulus#GO:0048584;multicellular organismal process#GO:0032501;positive regulation of immune response#GO:0050778;developmental process#GO:0032502;regulation of response to stimulus#GO:0048583;cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;leukocyte activation#GO:0045321;immune response-activating cell surface receptor signaling pathway#GO:0002429;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of immune response#GO:0050776;lymphocyte differentiation#GO:0030098;cell activation#GO:0001775;cell communication#GO:0007154;anatomical structure development#GO:0048856 side of membrane#GO:0098552;external side of plasma membrane#GO:0009897;signaling receptor complex#GO:0043235;plasma membrane#GO:0005886;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane protein complex#GO:0098796;membrane#GO:0016020 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 B cell activation#P00010>Ig-beta#P00377 HUMAN|HGNC=26307|UniProtKB=Q8WVB3 Q8WVB3 HEXD PTHR21040:SF6 BCDNA.GH04120 HEXOSAMINIDASE D hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553 HUMAN|HGNC=18380|UniProtKB=Q7L1Q6 Q7L1Q6 BZW1 PTHR14208:SF0 BASIC LEUCINE ZIPPER AND W2 DOMAIN-CONTAINING PROTEIN EIF5-MIMIC PROTEIN 2 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 basic leucine zipper transcription factor#PC00056 HUMAN|HGNC=13972|UniProtKB=Q9UGF6 Q9UGF6 OR5V1 PTHR26453:SF295 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5V1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 system process#GO:0003008;sensory perception#GO:0007600;nervous system process#GO:0050877;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;response to chemical#GO:0042221;response to stimulus#GO:0050896;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;detection of chemical stimulus#GO:0009593;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=28585|UniProtKB=Q9UGY1 Q9UGY1 NOL12 PTHR14577:SF0 NUCLEOLAR PROTEIN 12 NUCLEOLAR PROTEIN 12 RNA binding#GO:0003723;binding#GO:0005488;rRNA binding#GO:0019843;nucleic acid binding#GO:0003676 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226 HUMAN|HGNC=784|UniProtKB=P15336 P15336 ATF2 PTHR19304:SF9 CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-2 cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 basic leucine zipper transcription factor#PC00056 Apoptosis signaling pathway#P00006>ATF#P00302;Gonadotropin-releasing hormone receptor pathway#P06664>ATF2#P06732;Oxidative stress response#P00046>ATF2#P01126;TGF-beta signaling pathway#P00052>Co-activators corepressors#P01282;CCKR signaling map#P06959>ATF2#P07078;Ras Pathway#P04393>ATF2#P04548 HUMAN|HGNC=1438|UniProtKB=P10092 P10092 CALCB PTHR10505:SF3 CALCITONIN-RELATED CALCITONIN GENE-RELATED PEPTIDE 2 protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102;G protein-coupled receptor binding#GO:0001664 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 peptide hormone#PC00179 HUMAN|HGNC=29583|UniProtKB=Q5JQS6 Q5JQS6 GCSAML PTHR35351:SF1 GERMINAL CENTER-ASSOCIATED SIGNALING AND MOTILITY-LIKE PROTEIN GERMINAL CENTER-ASSOCIATED SIGNALING AND MOTILITY-LIKE PROTEIN HUMAN|HGNC=1388|UniProtKB=O00555 O00555 CACNA1A PTHR45628:SF3 VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1 VOLTAGE-DEPENDENT P_Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A voltage-gated calcium channel activity#GO:0005245;channel activity#GO:0015267;monoatomic cation channel activity#GO:0005261;passive transmembrane transporter activity#GO:0022803;calcium channel activity#GO:0005262;transmembrane transporter activity#GO:0022857;voltage-gated channel activity#GO:0022832;calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;transporter activity#GO:0005215 chemical synaptic transmission#GO:0007268;calcium ion transmembrane transport#GO:0070588;calcium ion import#GO:0070509;regulation of biological process#GO:0050789;import across plasma membrane#GO:0098739;anterograde trans-synaptic signaling#GO:0098916;inorganic ion import across plasma membrane#GO:0099587;signaling#GO:0023052;metal ion transport#GO:0030001;trans-synaptic signaling#GO:0099537;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;cell communication#GO:0007154;monoatomic ion transport#GO:0006811;synaptic signaling#GO:0099536;cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;monoatomic cation transmembrane transport#GO:0098655;transport#GO:0006810;calcium ion transmembrane import into cytosol#GO:0097553;import into cell#GO:0098657;establishment of localization#GO:0051234;calcium ion transport#GO:0006816;inorganic cation import across plasma membrane#GO:0098659 cellular anatomical structure#GO:0110165;neuronal cell body#GO:0043025;membrane protein complex#GO:0098796;voltage-gated calcium channel complex#GO:0005891;cell body#GO:0044297;calcium channel complex#GO:0034704;plasma membrane protein complex#GO:0098797;transmembrane transporter complex#GO:1902495;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;transporter complex#GO:1990351;cation channel complex#GO:0034703 voltage-gated ion channel#PC00241 Endogenous cannabinoid signaling#P05730>Ca2+ channel#P05750;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Ca2+channel#P00742;Ionotropic glutamate receptor pathway#P00037>Ca2+ channel#P01022;GABA-B receptor II signaling#P05731>Ca channel#P05753;Thyrotropin-releasing hormone receptor signaling pathway#P04394>Ca2+ channel#P04587;Metabotropic glutamate receptor group III pathway#P00039>Ca2+#P01041;Metabotropic glutamate receptor group II pathway#P00040>Ca2+#P01051 HUMAN|HGNC=14343|UniProtKB=Q9BXI9 Q9BXI9 C1QTNF6 PTHR22923:SF70 CEREBELLIN-RELATED COMPLEMENT C1Q TUMOR NECROSIS FACTOR-RELATED PROTEIN 6 pattern recognition receptor activity#GO:0038187;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=15172|UniProtKB=Q8NGL9 Q8NGL9 OR4C16 PTHR48002:SF106 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 4C16 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=6394|UniProtKB=P52294 P52294 KPNA1 PTHR23316:SF3 IMPORTIN ALPHA IMPORTIN SUBUNIT ALPHA-5 molecular carrier activity#GO:0140104;nucleocytoplasmic carrier activity#GO:0140142 regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;protein localization to organelle#GO:0033365;nucleocytoplasmic transport#GO:0006913;nuclear transport#GO:0051169;protein transport#GO:0015031;protein import into nucleus#GO:0006606;cell communication#GO:0007154;NLS-bearing protein import into nucleus#GO:0006607;localization#GO:0051179;cellular localization#GO:0051641;signal transduction#GO:0007165;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule localization#GO:0033036;import into nucleus#GO:0051170;synaptic signaling#GO:0099536;protein localization to nucleus#GO:0034504;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 transporter#PC00227 HUMAN|HGNC=27097|UniProtKB=A6NFN3 A6NFN3 RBFOX3 PTHR15597:SF25 ATAXIN 2-BINDING PROTEIN 1-RELATED RNA BINDING PROTEIN FOX-1 HOMOLOG 3 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729 regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;animal gross anatomical part developmental process#GO:0160108;anatomical structure development#GO:0048856;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;regulation of alternative mRNA splicing, via spliceosome#GO:0000381;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;multicellular organismal process#GO:0032501;regulation of mRNA processing#GO:0050684;regulation of nucleobase-containing compound metabolic process#GO:0019219;nervous system development#GO:0007399;regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;regulation of mRNA metabolic process#GO:1903311;multicellular organism development#GO:0007275;regulation of gene expression#GO:0010468 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 RNA splicing factor#PC00148;RNA processing factor#PC00147 HUMAN|HGNC=25617|UniProtKB=Q96IZ5 Q96IZ5 RBM41 PTHR16105:SF2 RNA-BINDING REGION-CONTAINING PROTEIN 3 RNA-BINDING PROTEIN 41 HUMAN|HGNC=20685|UniProtKB=Q8N271 Q8N271 PROM2 PTHR22730:SF6 PROMININ PROM PROTEIN PROMININ-2 cellular process#GO:0009987;cellular component organization#GO:0016043;plasma membrane bounded cell projection organization#GO:0120036;cellular component organization or biogenesis#GO:0071840;cell projection organization#GO:0030030 plasma membrane region#GO:0098590;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;apical part of cell#GO:0045177;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;actin cytoskeleton#GO:0015629;apical plasma membrane#GO:0016324;vesicle#GO:0031982;actin-based cell projection#GO:0098858;microvillus#GO:0005902;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cilium#GO:0005929;extracellular region#GO:0005576 HUMAN|HGNC=16049|UniProtKB=Q15185 Q15185 PTGES3 PTHR22932:SF3 TELOMERASE-BINDING PROTEIN P23 HSP90 CO-CHAPERONE PROSTAGLANDIN E SYNTHASE 3 binding#GO:0005488;Hsp90 protein binding#GO:0051879;protein binding#GO:0005515;catalytic activity#GO:0003824;protein-folding chaperone binding#GO:0051087;heat shock protein binding#GO:0031072;intramolecular oxidoreductase activity#GO:0016860;isomerase activity#GO:0016853 unsaturated fatty acid metabolic process#GO:0033559;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;DNA metabolic process#GO:0006259;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;protein-RNA complex organization#GO:0071826;DNA biosynthetic process#GO:0071897;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;icosanoid biosynthetic process#GO:0046456;cellular component assembly#GO:0022607;icosanoid metabolic process#GO:0006690;telomere maintenance via telomere lengthening#GO:0010833;telomere maintenance via telomerase#GO:0007004;gene expression#GO:0010467;protein maturation#GO:0051604;nucleic acid biosynthetic process#GO:0141187;oxoacid metabolic process#GO:0043436;protein-containing complex assembly#GO:0065003;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;cellular component organization#GO:0016043;ribonucleoprotein complex biogenesis#GO:0022613;protein folding#GO:0006457;small molecule metabolic process#GO:0044281;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;RNA-templated DNA biosynthetic process#GO:0006278;fatty acid metabolic process#GO:0006631;telomere maintenance#GO:0000723;chromosome organization#GO:0051276;macromolecule metabolic process#GO:0043170;monocarboxylic acid biosynthetic process#GO:0072330;macromolecule biosynthetic process#GO:0009059;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;fatty acid biosynthetic process#GO:0006633;unsaturated fatty acid biosynthetic process#GO:0006636;lipid biosynthetic process#GO:0008610;prostaglandin metabolic process#GO:0006693;chaperone-mediated protein complex assembly#GO:0051131;telomere organization#GO:0032200;protein-RNA complex assembly#GO:0022618;protein metabolic process#GO:0019538;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;cytosol#GO:0005829 chaperone#PC00072 HUMAN|HGNC=21376|UniProtKB=Q5VVH2 Q5VVH2 FKBP1C PTHR10516:SF301 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP1A-RELATED catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;cis-trans isomerase activity#GO:0016859;isomerase activity#GO:0016853;peptidyl-prolyl cis-trans isomerase activity#GO:0003755 metabolic process#GO:0008152;regulation of release of sequestered calcium ion into cytosol#GO:0051279;regulation of transport#GO:0051049;regulation of localization#GO:0032879;regulation of monoatomic ion transmembrane transport#GO:0034765;cellular process#GO:0009987;signal transduction#GO:0007165;intracellular signaling cassette#GO:0141124;regulation of multicellular organismal process#GO:0051239;protein maturation#GO:0051604;gene expression#GO:0010467;regulation of muscle contraction#GO:0006937;regulation of biological process#GO:0050789;regulation of muscle system process#GO:0090257;protein folding#GO:0006457;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of system process#GO:0044057;regulation of monoatomic cation transmembrane transport#GO:1904062;calcium-mediated signaling#GO:0019722;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;biological regulation#GO:0065007;regulation of calcium ion transport#GO:0051924;biosynthetic process#GO:0009058;regulation of monoatomic ion transport#GO:0043269;intracellular signal transduction#GO:0035556;protein metabolic process#GO:0019538;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;regulation of transmembrane transport#GO:0034762;regulation of heart contraction#GO:0008016;regulation of cellular process#GO:0050794;regulation of metal ion transport#GO:0010959 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;sarcoplasm#GO:0016528;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;sarcoplasmic reticulum#GO:0016529;membrane#GO:0016020;cytoplasm#GO:0005737;sarcoplasmic reticulum membrane#GO:0033017;endomembrane system#GO:0012505;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588 chaperone#PC00072 TGF-beta signaling pathway#P00052>FKBP12#P01288 HUMAN|HGNC=1578|UniProtKB=P20248 P20248 CCNA2 PTHR10177:SF444 CYCLINS CYCLIN-A2 cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;protein kinase regulator activity#GO:0019887;cyclin-dependent protein kinase regulator activity#GO:0019914 G1/S transition of mitotic cell cycle#GO:0000082;mitotic cell cycle phase transition#GO:0044772;mitotic cell cycle process#GO:1903047;cell cycle#GO:0007049;cellular process#GO:0009987;cell cycle process#GO:0022402;cell cycle G1/S phase transition#GO:0044843;cell cycle phase transition#GO:0044770;mitotic cell cycle#GO:0000278 transferase complex#GO:1990234;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;protein kinase complex#GO:1902911;membraneless organelle#GO:0043228;nucleus#GO:0005634;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 kinase activator#PC00138 p53 pathway feedback loops 2#P04398>cyclin A#P04666 HUMAN|HGNC=1590|UniProtKB=O96020 O96020 CCNE2 PTHR10177:SF70 CYCLINS G1_S-SPECIFIC CYCLIN-E2 enzyme regulator activity#GO:0030234;protein kinase regulator activity#GO:0019887;cyclin-dependent protein kinase regulator activity#GO:0019914;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538 positive regulation of mitotic cell cycle#GO:0045931;mitotic cell cycle process#GO:1903047;G1/S transition of mitotic cell cycle#GO:0000082;positive regulation of cell cycle G1/S phase transition#GO:1902808;positive regulation of cell cycle#GO:0045787;biological regulation#GO:0065007;regulation of cell cycle process#GO:0010564;cellular process#GO:0009987;regulation of mitotic cell cycle#GO:0007346;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cell cycle G1/S phase transition#GO:0044843;regulation of mitotic cell cycle phase transition#GO:1901990;regulation of G1/S transition of mitotic cell cycle#GO:2000045;mitotic cell cycle phase transition#GO:0044772;regulation of cell cycle#GO:0051726;regulation of cell cycle G1/S phase transition#GO:1902806;regulation of cellular process#GO:0050794;cell cycle phase transition#GO:0044770;mitotic cell cycle#GO:0000278;cell cycle process#GO:0022402;positive regulation of cell cycle process#GO:0090068;regulation of biological process#GO:0050789;regulation of cell cycle phase transition#GO:1901987;cell cycle#GO:0007049 nucleus#GO:0005634;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle#GO:0043229;transferase complex#GO:1990234;catalytic complex#GO:1902494;protein kinase complex#GO:1902911;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554 kinase activator#PC00138 Parkinson disease#P00049>Cyclin E#P01213;Cell cycle#P00013>CdkC#P00489 HUMAN|HGNC=6036|UniProtKB=Q01167 Q01167 FOXK2 PTHR45881:SF3 CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED FORKHEAD BOX PROTEIN K2 HUMAN|HGNC=16916|UniProtKB=Q8IUN9 Q8IUN9 CLEC10A PTHR22802:SF416 C-TYPE LECTIN SUPERFAMILY MEMBER C-TYPE LECTIN DOMAIN FAMILY 10 MEMBER A signaling receptor activity#GO:0038023;carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187;molecular transducer activity#GO:0060089;binding#GO:0005488 response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 plasma membrane#GO:0005886;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;membrane#GO:0016020 membrane traffic protein#PC00150 HUMAN|HGNC=15996|UniProtKB=Q9UK55 Q9UK55 SERPINA10 PTHR11461:SF191 SERINE PROTEASE INHIBITOR, SERPIN PROTEIN Z-DEPENDENT PROTEASE INHIBITOR enzyme inhibitor activity#GO:0004857;endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414;peptidase regulator activity#GO:0061134;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;serine-type endopeptidase inhibitor activity#GO:0004867 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease inhibitor#PC00191 Blood coagulation#P00011>ZPI#P00425 HUMAN|HGNC=6588|UniProtKB=Q6ZUX7 Q6ZUX7 LHFPL2 PTHR12489:SF19 LIPOMA HMGIC FUSION PARTNER-LIKE PROTEIN LHFPL TETRASPAN SUBFAMILY MEMBER 2 PROTEIN membrane#GO:0016020;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=25857|UniProtKB=Q8NE18 Q8NE18 NSUN7 PTHR14663:SF2 METHYLTRANSFERASE NSUN7-RELATED PROTEIN NSUN7 HUMAN|HGNC=21292|UniProtKB=Q9UJD0 Q9UJD0 RIMS3 PTHR12157:SF25 REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN 3 structural molecule activity#GO:0005198;structural constituent of synapse#GO:0098918 neurotransmitter secretion#GO:0007269;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;establishment of localization#GO:0051234;synaptic vesicle cycle#GO:0099504;transport#GO:0006810;regulation of cell communication#GO:0010646;modulation of chemical synaptic transmission#GO:0050804;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;chemical synaptic transmission#GO:0007268;signal release from synapse#GO:0099643;regulation of exocytosis#GO:0017157;secretion#GO:0046903;cell communication#GO:0007154;localization#GO:0051179;regulation of secretion#GO:0051046;trans-synaptic signaling#GO:0099537;signal release#GO:0023061;neurotransmitter transport#GO:0006836;vesicle-mediated transport#GO:0016192;regulation of trans-synaptic signaling#GO:0099177;cellular component assembly#GO:0022607;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;synaptic vesicle exocytosis#GO:0016079;synaptic signaling#GO:0099536;cellular component biogenesis#GO:0044085;protein-containing complex organization#GO:0043933;regulation of localization#GO:0032879;exocytosis#GO:0006887;regulation of transport#GO:0051049;vesicle-mediated transport in synapse#GO:0099003;cellular component organization or biogenesis#GO:0071840;exocytic process#GO:0140029;regulated exocytosis#GO:0045055;regulation of synaptic vesicle exocytosis#GO:2000300;signaling#GO:0023052;export from cell#GO:0140352;regulation of neurotransmitter secretion#GO:0046928;protein-containing complex assembly#GO:0065003;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;cellular component organization#GO:0016043;regulation of secretion by cell#GO:1903530;secretion by cell#GO:0032940;cellular localization#GO:0051641;regulation of signaling#GO:0023051;regulation of neurotransmitter transport#GO:0051588 membrane#GO:0016020;presynapse#GO:0098793;cell cortex#GO:0005938;cell periphery#GO:0071944;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;synapse#GO:0045202;plasma membrane#GO:0005886;presynaptic membrane#GO:0042734;cytoplasm#GO:0005737;synaptic membrane#GO:0097060;cell junction#GO:0030054;presynaptic active zone#GO:0048786;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HUMAN|HGNC=9118|UniProtKB=Q01453 Q01453 PMP22 PTHR10671:SF114 EPITHELIAL MEMBRANE PROTEIN-RELATED PERIPHERAL MYELIN PROTEIN 22 bleb assembly#GO:0032060;plasma membrane bounded cell projection assembly#GO:0120031;cellular anatomical entity morphogenesis#GO:0032989;developmental process#GO:0032502;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;neurogenesis#GO:0022008;myelination#GO:0042552;anatomical structure formation involved in morphogenesis#GO:0048646;gliogenesis#GO:0042063;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cell projection assembly#GO:0030031;multicellular organismal process#GO:0032501;glial cell differentiation#GO:0010001;cellular component assembly#GO:0022607;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly involved in morphogenesis#GO:0010927;animal gross anatomical part developmental process#GO:0160108;anatomical structure development#GO:0048856;system development#GO:0048731;cellular component organization#GO:0016043;peripheral nervous system development#GO:0007422;anatomical structure morphogenesis#GO:0009653;cell differentiation#GO:0030154;cell projection organization#GO:0030030 plasma membrane#GO:0005886;myelin sheath#GO:0043209;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 cytoskeletal protein#PC00085 HUMAN|HGNC=30043|UniProtKB=Q9NWQ8 Q9NWQ8 PAG1 PTHR16322:SF0 PHOSPHOPROTEIN ASSOCIATED WITH GLYCOSPHINGOLIPID-ENRICHED MICRODOMAINS 1 PHOSPHOPROTEIN ASSOCIATED WITH GLYCOSPHINGOLIPID-ENRICHED MICRODOMAINS 1 regulation of biological process#GO:0050789;regulation of cell activation#GO:0050865;cellular response to stimulus#GO:0051716;regulation of leukocyte activation#GO:0002694;negative regulation of multicellular organismal process#GO:0051241;negative regulation of biological process#GO:0048519;signaling#GO:0023052;negative regulation of leukocyte cell-cell adhesion#GO:1903038;regulation of lymphocyte activation#GO:0051249;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of cell-cell adhesion#GO:0022407;regulation of immune system process#GO:0002682;negative regulation of T cell activation#GO:0050868;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;negative regulation of immune system process#GO:0002683;regulation of multicellular organismal process#GO:0051239;negative regulation of lymphocyte activation#GO:0051250;negative regulation of leukocyte activation#GO:0002695;negative regulation of cell-cell adhesion#GO:0022408;negative regulation of cell adhesion#GO:0007162;regulation of cell adhesion#GO:0030155;regulation of T cell activation#GO:0050863;regulation of leukocyte cell-cell adhesion#GO:1903037;negative regulation of cellular process#GO:0048523;negative regulation of cell activation#GO:0050866 cell periphery#GO:0071944;membrane microdomain#GO:0098857;membrane#GO:0016020;membrane raft#GO:0045121;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 HUMAN|HGNC=13592|UniProtKB=O94952 O94952 FBXO21 PTHR31350:SF21 SI:DKEY-261L7.2 F-BOX ONLY PROTEIN 21 HUMAN|HGNC=16781|UniProtKB=Q9BXD5 Q9BXD5 NPL PTHR12128:SF21 DIHYDRODIPICOLINATE SYNTHASE N-ACETYLNEURAMINATE LYASE lyase activity#GO:0016829;catalytic activity#GO:0003824 lyase#PC00144 N-acetylglucosamine metabolism#P02756>N-acetylneuraminate lyase#P03040 HUMAN|HGNC=28136|UniProtKB=Q5XUX1 Q5XUX1 FBXW9 PTHR19855:SF34 WD40 REPEAT PROTEIN 12, 37 F-BOX_WD REPEAT-CONTAINING PROTEIN 9 HUMAN|HGNC=37273|UniProtKB=B4DU55 B4DU55 ZNF879 PTHR24377:SF626 IP01015P-RELATED ZINC FINGER PROTEIN 879 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=30856|UniProtKB=Q96G21 Q96G21 IMP4 PTHR22734:SF2 U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4 U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4 binding#GO:0005488;snoRNA binding#GO:0030515;nucleic acid binding#GO:0003676;rRNA binding#GO:0019843;RNA binding#GO:0003723 cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;ribosomal small subunit biogenesis#GO:0042274;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;preribosome#GO:0030684;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular organelle#GO:0043229;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;90S preribosome#GO:0030686;organelle lumen#GO:0043233;small-subunit processome#GO:0032040 RNA splicing factor#PC00148;RNA processing factor#PC00147 HUMAN|HGNC=12019|UniProtKB=Q15661 Q15661 TPSAB1 PTHR24256:SF532 TRYPTASE-RELATED TRYPTASE ALPHA_BETA-1-RELATED serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;serine-type peptidase activity#GO:0008236 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;cellular process#GO:0009987;proteolysis#GO:0006508;metabolic process#GO:0008152;primary metabolic process#GO:0044238 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 serine protease#PC00203 HUMAN|HGNC=16160|UniProtKB=Q9H147 Q9H147 DNTTIP1 PTHR23399:SF2 DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 1 DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 1 chromatin-protein adaptor activity#GO:0140463;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 cellular process#GO:0009987;cellular component organization#GO:0016043;chromatin organization#GO:0006325;cellular component organization or biogenesis#GO:0071840 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 HUMAN|HGNC=19234|UniProtKB=Q6P4F1 Q6P4F1 POFUT3 PTHR11929:SF194 ALPHA- 1,3 -FUCOSYLTRANSFERASE GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 3 glycosyltransferase#PC00111 HUMAN|HGNC=25712|UniProtKB=Q75T13 Q75T13 PGAP1 PTHR15495:SF7 NEGATIVE REGULATOR OF VESICLE FORMATION-RELATED GPI INOSITOL-DEACYLASE deacylase activity#GO:0160215;catalytic activity#GO:0003824 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 transporter#PC00227 HUMAN|HGNC=30657|UniProtKB=Q9BRV3 Q9BRV3 SLC50A1 PTHR10791:SF30 RAG1-ACTIVATING PROTEIN 1 SUGAR TRANSPORTER SWEET1 carbohydrate transmembrane transporter activity#GO:0015144;sugar transmembrane transporter activity#GO:0051119;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810;carbohydrate transport#GO:0008643 membrane#GO:0016020;cellular anatomical structure#GO:0110165 HUMAN|HGNC=1102|UniProtKB=O95696 O95696 BRD1 PTHR13793:SF17 PHD FINGER PROTEINS BROMODOMAIN-CONTAINING PROTEIN 1 chromatin-protein adaptor activity#GO:0140463;histone reader activity#GO:0140566;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 chromatin remodeling#GO:0006338;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;chromatin organization#GO:0006325;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840 nucleus#GO:0005634;chromatin#GO:0000785;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;transferase complex#GO:1990234;histone acetyltransferase complex#GO:0000123;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;protein acetyltransferase complex#GO:0031248;membrane-bounded organelle#GO:0043227;acetyltransferase complex#GO:1902493;intracellular anatomical structure#GO:0005622 zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=14773|UniProtKB=P0DN80 P0DN80 OR5H8 PTHR26452:SF775 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5H8 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 sensory perception of chemical stimulus#GO:0007606;sensory perception#GO:0007600;nervous system process#GO:0050877;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;system process#GO:0003008 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=29307|UniProtKB=Q9P1Y5 Q9P1Y5 CAMSAP3 PTHR21595:SF2 PATRONIN CALMODULIN-REGULATED SPECTRIN-ASSOCIATED PROTEIN 3 binding#GO:0005488;microtubule binding#GO:0008017;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515 regulation of microtubule polymerization or depolymerization#GO:0031110;microtubule-based process#GO:0007017;regulation of protein depolymerization#GO:1901879;cellular component organization or biogenesis#GO:0071840;negative regulation of cellular process#GO:0048523;negative regulation of protein depolymerization#GO:1901880;regulation of microtubule cytoskeleton organization#GO:0070507;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;cellular process#GO:0009987;regulation of protein-containing complex disassembly#GO:0043244;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;microtubule cytoskeleton organization#GO:0000226;negative regulation of protein-containing complex disassembly#GO:0043242;negative regulation of cytoskeleton organization#GO:0051494;regulation of microtubule-based process#GO:0032886;cytoplasmic microtubule organization#GO:0031122;regulation of cellular process#GO:0050794;negative regulation of supramolecular fiber organization#GO:1902904;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of supramolecular fiber organization#GO:1902903;cellular component organization#GO:0016043;negative regulation of cellular component organization#GO:0051129;negative regulation of organelle organization#GO:0010639;negative regulation of biological process#GO:0048519 supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;supramolecular complex#GO:0099080;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;microtubule end#GO:1990752;microtubule cytoskeleton#GO:0015630 HUMAN|HGNC=6134|UniProtKB=P56199 P56199 ITGA1 PTHR23220:SF22 INTEGRIN ALPHA INTEGRIN ALPHA-1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cell surface receptor signaling pathway#GO:0007166;cell-matrix adhesion#GO:0007160;cell adhesion#GO:0007155;cell communication#GO:0007154;cell-substrate adhesion#GO:0031589;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell-cell adhesion#GO:0098609;integrin-mediated signaling pathway#GO:0007229;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;protein complex involved in cell adhesion#GO:0098636;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane#GO:0005886;cell surface#GO:0009986;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;signaling receptor complex#GO:0043235;integrin complex#GO:0008305 integrin#PC00126;cell adhesion molecule#PC00069 Integrin signalling pathway#P00034>Integrin alpha#P00941;Gonadotropin-releasing hormone receptor pathway#P06664>alpha-beta integrin dimer#P06820 HUMAN|HGNC=4549|UniProtKB=Q13098 Q13098 GPS1 PTHR14145:SF2 26S PROTESOME SUBUNIT 6 COP9 SIGNALOSOME COMPLEX SUBUNIT 1 metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647;protein stabilization#GO:0050821;regulation of biological quality#GO:0065008;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;regulation of protein stability#GO:0031647;primary metabolic process#GO:0044238;protein modification process#GO:0036211;post-translational protein modification#GO:0043687;biological regulation#GO:0065007 nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;COP9 signalosome#GO:0008180;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=6972|UniProtKB=P21741 P21741 MDK PTHR13850:SF2 PLEIOTROPHIN FAMILY MEMBER MIDKINE growth factor activity#GO:0008083;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546 growth factor#PC00112;intercellular signal molecule#PC00207 HUMAN|HGNC=20364|UniProtKB=A1L390 A1L390 PLEKHG3 PTHR45924:SF4 FI17866P1 PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 3 molecular function regulator activity#GO:0098772;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;protein binding#GO:0005515;enzyme regulator activity#GO:0030234;small GTPase binding#GO:0031267;enzyme binding#GO:0019899;guanyl-nucleotide exchange factor activity#GO:0005085;binding#GO:0005488 regulation of establishment or maintenance of cell polarity#GO:0032878;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of biological process#GO:0050789 HUMAN|HGNC=17211|UniProtKB=Q92620 Q92620 DHX38 PTHR18934:SF91 ATP-DEPENDENT RNA HELICASE PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16 catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;RNA helicase activity#GO:0003724;nucleic acid conformation isomerase activity#GO:0120545;macromolecular conformation isomerase activity#GO:0120543;helicase activity#GO:0004386;isomerase activity#GO:0016853;catalytic activity, acting on RNA#GO:0140098;binding#GO:0005488;nucleic acid binding#GO:0003676;ATP-dependent activity#GO:0140657;RNA binding#GO:0003723 mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;spliceosomal complex#GO:0005681 RNA helicase#PC00032;RNA metabolism protein#PC00031 HUMAN|HGNC=15213|UniProtKB=Q8NGH9 Q8NGH9 OR52E4 PTHR26450:SF13 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 52E4 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=24876|UniProtKB=Q7Z5G4 Q7Z5G4 GOLGA7 PTHR13254:SF1 GOLGI AUTOANTIGEN, GOLGIN SUBFAMILY A, 7 GOLGIN SUBFAMILY A MEMBER 7 transport#GO:0006810;Golgi vesicle transport#GO:0048193;protein targeting to membrane#GO:0006612;protein localization to cell periphery#GO:1990778;vesicle-mediated transport to the plasma membrane#GO:0098876;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;establishment of protein localization#GO:0045184;cellular process#GO:0009987;establishment of protein localization to membrane#GO:0090150;macromolecule localization#GO:0033036;vesicle-mediated transport#GO:0016192;establishment of protein localization to plasma membrane#GO:0061951;localization within membrane#GO:0051668;post-Golgi vesicle-mediated transport#GO:0006892;protein transport#GO:0015031;localization#GO:0051179;cellular localization#GO:0051641;protein localization to membrane#GO:0072657;protein localization to plasma membrane#GO:0072659;Golgi to plasma membrane protein transport#GO:0043001;Golgi to plasma membrane transport#GO:0006893;protein targeting#GO:0006605 Golgi apparatus#GO:0005794;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex#GO:1990234;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;Golgi apparatus subcompartment#GO:0098791;Golgi stack#GO:0005795;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=30003|UniProtKB=Q5VUE5 Q5VUE5 C1orf53 PTHR21037:SF2 39S RIBOSOMAL PROTEIN L14, MITOCHONDRIAL SIMILAR TO HUMAN CHROMOSOME 1 OPEN READING FRAME 53 ribosomal protein#PC00202;translational protein#PC00263 HUMAN|HGNC=5575|UniProtKB=A0A0B4J1V2 A0A0B4J1V2 IGHV2-26 PTHR23266:SF281 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 2-26 antigen binding#GO:0003823;binding#GO:0005488 immune effector process#GO:0002252;immune system process#GO:0002376;immunoglobulin mediated immune response#GO:0016064;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449;immune response#GO:0006955;adaptive immune response#GO:0002250;response to stimulus#GO:0050896 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=10880|UniProtKB=P40967 P40967 PMEL PTHR11861:SF1 MELANOCYTE PROTEIN PMEL 17-RELATED MELANOCYTE PROTEIN PMEL pigmentation#GO:0043473;melanosome organization#GO:0032438;cellular component organization or biogenesis#GO:0071840;vesicle organization#GO:0016050;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;cellular pigmentation#GO:0033059 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;intracellular vesicle#GO:0097708;cell periphery#GO:0071944;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;melanosome#GO:0042470;plasma membrane#GO:0005886 membrane-bound signaling molecule#PC00152 HUMAN|HGNC=8194|UniProtKB=O43749 O43749 OR1F1 PTHR48001:SF98 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 1F1-RELATED transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cell communication#GO:0007154 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=39005|UniProtKB=P63128 P63128 ERVK-9 PTHR40389:SF2 ENDOGENOUS RETROVIRUS GROUP K MEMBER 24 GAG POLYPROTEIN-RELATED ENDOGENOUS RETROVIRUS GROUP K MEMBER 24 GAG POLYPROTEIN-RELATED HUMAN|HGNC=22202|UniProtKB=Q86XD5 Q86XD5 FAM131B PTHR15736:SF9 PROTEIN FAM131B-RELATED PROTEIN FAM131B HUMAN|HGNC=28949|UniProtKB=Q15051 Q15051 IQCB1 PTHR15673:SF2 IQ CALMODULIN-BINDING MOTIF CONTAINING PROTEIN 1 IQ CALMODULIN-BINDING MOTIF-CONTAINING PROTEIN 1 plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cell projection organization#GO:0030030;cellular process#GO:0009987;cell projection assembly#GO:0030031;cilium assembly#GO:0060271;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cilium organization#GO:0044782;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection assembly#GO:0120031;organelle assembly#GO:0070925 cilium#GO:0005929;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;membrane-bounded organelle#GO:0043227;plasma membrane bounded cell projection#GO:0120025 HUMAN|HGNC=7830|UniProtKB=Q16617 Q16617 NKG7 PTHR10671:SF34 EPITHELIAL MEMBRANE PROTEIN-RELATED PROTEIN NKG7 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 cytoskeletal protein#PC00085 HUMAN|HGNC=15892|UniProtKB=Q9Y3B1 Q9Y3B1 PRELID3B PTHR11158:SF22 MSF1/PX19 RELATED PRELI DOMAIN CONTAINING PROTEIN 3B phospholipid transfer activity#GO:0120014;lipid transfer activity#GO:0120013;lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104;transporter activity#GO:0005215 localization#GO:0051179;establishment of localization#GO:0051234;lipid localization#GO:0010876;transport#GO:0006810;organophosphate ester transport#GO:0015748;lipid transport#GO:0006869;phospholipid transport#GO:0015914;macromolecule localization#GO:0033036 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;mitochondrion#GO:0005739;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;mitochondrial intermembrane space#GO:0005758;intracellular organelle#GO:0043229 transfer/carrier protein#PC00219 HUMAN|HGNC=14099|UniProtKB=Q9ULM6 Q9ULM6 CNOT6 PTHR12121:SF33 CARBON CATABOLITE REPRESSOR PROTEIN 4 CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 6 catalytic activity, acting on RNA#GO:0140098;3'-5' exonuclease activity#GO:0008408;RNA nuclease activity#GO:0004540;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;nuclease activity#GO:0004518;exonuclease activity#GO:0004527;3'-5'-RNA exonuclease activity#GO:0000175 metabolic process#GO:0008152;mRNA destabilization#GO:0061157;macromolecule catabolic process#GO:0009057;positive regulation of mRNA metabolic process#GO:1903313;regulation of mRNA metabolic process#GO:1903311;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;RNA destabilization#GO:0050779;positive regulation of macromolecule metabolic process#GO:0010604;RNA catabolic process#GO:0006401;regulation of biological quality#GO:0065008;positive regulation of metabolic process#GO:0009893;RNA metabolic process#GO:0016070;regulation of biological process#GO:0050789;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;regulation of mRNA stability#GO:0043488;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;macromolecule metabolic process#GO:0043170;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;positive regulation of catabolic process#GO:0009896;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;nucleic acid catabolic process#GO:0141188;nucleobase-containing compound catabolic process#GO:0034655;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA stability#GO:0043487;regulation of RNA metabolic process#GO:0051252;positive regulation of mRNA catabolic process#GO:0061014;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;nuclear-transcribed mRNA poly(A) tail shortening#GO:0000289;catabolic process#GO:0009056;regulation of cellular process#GO:0050794 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227;CCR4-NOT complex#GO:0030014;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 mRNA polyadenylation factor#PC00146 HUMAN|HGNC=7213|UniProtKB=O00566 O00566 MPHOSPH10 PTHR17039:SF0 U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10 U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10 membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;preribosome#GO:0030684;ribonucleoprotein complex#GO:1990904;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;small-subunit processome#GO:0032040;90S preribosome#GO:0030686;organelle lumen#GO:0043233 RNA metabolism protein#PC00031 HUMAN|HGNC=24435|UniProtKB=Q9NRR1 Q9NRR1 CYTL1 PTHR15974:SF0 CYTOKINE-LIKE PROTEIN 1 CYTOKINE-LIKE PROTEIN 1 regulation of biological process#GO:0050789;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of DNA-templated transcription#GO:0006355;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 cytokine#PC00083 HUMAN|HGNC=17318|UniProtKB=Q8WXD0 Q8WXD0 RXFP2 PTHR24372:SF72 GLYCOPROTEIN HORMONE RECEPTOR RELAXIN RECEPTOR 2 transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653 adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;response to chemical#GO:0042221;biological regulation#GO:0065007;response to hormone#GO:0009725;cellular process#GO:0009987;signal transduction#GO:0007165;hormone-mediated signaling pathway#GO:0009755;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887;regulation of cellular process#GO:0050794;cellular response to hormone stimulus#GO:0032870;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;signaling#GO:0023052;response to endogenous stimulus#GO:0009719;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021 HUMAN|HGNC=29157|UniProtKB=Q9Y2G8 Q9Y2G8 DNAJC16 PTHR44303:SF2 DNAJ HOMOLOG SUBFAMILY C MEMBER 16 DNAJ HOMOLOG SUBFAMILY C MEMBER 16 metabolic process#GO:0008152;regulation of anatomical structure size#GO:0090066;cellular component organization or biogenesis#GO:0071840;vacuole organization#GO:0007033;process utilizing autophagic mechanism#GO:0061919;regulation of biological quality#GO:0065008;organelle organization#GO:0006996;cellular component organization#GO:0016043;autophagy#GO:0006914;regulation of cellular component size#GO:0032535;cellular process#GO:0009987;autophagosome organization#GO:1905037;catabolic process#GO:0009056;biological regulation#GO:0065007;macroautophagy#GO:0016236 intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020 chaperone#PC00072 HUMAN|HGNC=11805|UniProtKB=Q13009 Q13009 TIAM1 PTHR46001:SF1 TIAM (MAMMALIAN TUMOR INVASION AND METASTASIS FACTOR) HOMOLOG RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR TIAM1 molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;guanyl-nucleotide exchange factor activity#GO:0005085 cellular process#GO:0009987;signal transduction#GO:0007165;regulation of neuron projection development#GO:0010975;intracellular signaling cassette#GO:0141124;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;regulation of cell projection organization#GO:0031344;regulation of axonogenesis#GO:0050770;regulation of anatomical structure morphogenesis#GO:0022603;regulation of plasma membrane bounded cell projection organization#GO:0120035;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signaling#GO:0023052;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 synapse#GO:0045202;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cytoplasm#GO:0005737;cytosol#GO:0005829;membrane#GO:0016020;cell periphery#GO:0071944;cell junction#GO:0030054;intracellular anatomical structure#GO:0005622 Ras Pathway#P04393>Tiam1#P04571 HUMAN|HGNC=25897|UniProtKB=Q8NA29 Q8NA29 MFSD2A PTHR11328:SF29 MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN SODIUM-DEPENDENT LYSOPHOSPHATIDYLCHOLINE SYMPORTER 1 secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;solute:monoatomic cation symporter activity#GO:0015294;monoatomic ion transmembrane transporter activity#GO:0015075;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;monocarboxylic acid transmembrane transporter activity#GO:0008028;symporter activity#GO:0015293;carboxylic acid transmembrane transporter activity#GO:0046943;organophosphate ester transmembrane transporter activity#GO:0015605;solute:sodium symporter activity#GO:0015370;carbohydrate derivative transmembrane transporter activity#GO:1901505;monoatomic cation transmembrane transporter activity#GO:0008324 cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;system process#GO:0003008;regulation of membrane lipid distribution#GO:0097035;organic acid transport#GO:0015849;transport#GO:0006810;carboxylic acid transport#GO:0046942;lipid transport#GO:0006869;multicellular organismal process#GO:0032501;phospholipid transport#GO:0015914;biological regulation#GO:0065007;membrane organization#GO:0061024;phospholipid translocation#GO:0045332;macromolecule localization#GO:0033036;cellular process#GO:0009987;fatty acid transport#GO:0015908;localization#GO:0051179;transmembrane transport#GO:0055085;regulation of biological quality#GO:0065008;monocarboxylic acid transport#GO:0015718;lipid localization#GO:0010876;circulatory system process#GO:0003013;organophosphate ester transport#GO:0015748;lipid translocation#GO:0034204;cellular component organization#GO:0016043;carbohydrate derivative transport#GO:1901264 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 primary active transporter#PC00068 HUMAN|HGNC=9008|UniProtKB=P98161 P98161 PKD1 PTHR46730:SF3 POLYCYSTIN-1 POLYCYSTIN-1 monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic cation channel activity#GO:0005261;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267 transport#GO:0006810;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;calcium ion transport#GO:0006816;metal ion transport#GO:0030001 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HUMAN|HGNC=18001|UniProtKB=O96008 O96008 TOMM40 PTHR10802:SF1 MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40 MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40 HOMOLOG transmembrane protein transporter activity#GO:0008320;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 mitochondrial transmembrane transport#GO:1990542;protein transport#GO:0015031;localization#GO:0051179;transmembrane transport#GO:0055085;cellular localization#GO:0051641;protein localization to mitochondrion#GO:0070585;mitochondrial transport#GO:0006839;protein localization to organelle#GO:0033365;protein transmembrane import into intracellular organelle#GO:0044743;intracellular protein transport#GO:0006886;protein transmembrane transport#GO:0071806;transport#GO:0006810;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;establishment of protein localization to organelle#GO:0072594;intracellular protein transmembrane transport#GO:0065002;establishment of localization#GO:0051234;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;macromolecule localization#GO:0033036;mitochondrial protein import pathway#GO:7770058;protein import into mitochondrial matrix#GO:0030150 organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;mitochondrial outer membrane#GO:0005741;mitochondrial outer membrane translocase complex#GO:0005742;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;organelle outer membrane#GO:0031968;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;outer membrane#GO:0019867;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;organelle envelope#GO:0031967;membrane protein complex#GO:0098796 transporter#PC00227;primary active transporter#PC00068 HUMAN|HGNC=6525|UniProtKB=P31025 P31025 LCN1 PTHR11430:SF136 LIPOCALIN LIPOCALIN-1 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 transfer/carrier protein#PC00219 HUMAN|HGNC=18152|UniProtKB=Q9NP84 Q9NP84 TNFRSF12A PTHR32037:SF2 TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 12A TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 12A transmembrane signal receptor#PC00197 HUMAN|HGNC=1757|UniProtKB=Q13634 Q13634 CDH18 PTHR24027:SF106 CADHERIN-23 CADHERIN-18 protein binding#GO:0005515;beta-catenin binding#GO:0008013;binding#GO:0005488;cell adhesion molecule binding#GO:0050839 cellular component organization or biogenesis#GO:0071840;cell-cell junction assembly#GO:0007043;developmental process#GO:0032502;cell-cell junction organization#GO:0045216;cell migration#GO:0016477;cellular component assembly#GO:0022607;cellular process#GO:0009987;cell-cell adhesion#GO:0098609;cellular component biogenesis#GO:0044085;anatomical structure development#GO:0048856;cell adhesion#GO:0007155;cell junction organization#GO:0034330;cell morphogenesis#GO:0000902;cell motility#GO:0048870;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;adherens junction organization#GO:0034332;cell junction assembly#GO:0034329 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane protein complex#GO:0098796;membrane#GO:0016020;cell-cell junction#GO:0005911;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;extrinsic component of membrane#GO:0019898;cell junction#GO:0030054;extrinsic component of plasma membrane#GO:0019897;adherens junction#GO:0005912;anchoring junction#GO:0070161 cell adhesion molecule#PC00069;cadherin#PC00057 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HUMAN|HGNC=20265|UniProtKB=Q9NXR5 Q9NXR5 ANKRD10 PTHR24203:SF14 ANKYRIN REPEAT FAMILY PROTEIN ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 10 HUMAN|HGNC=18705|UniProtKB=P47944 P47944 MT4 PTHR23299:SF12 METALLOTHIONEIN METALLOTHIONEIN-4 ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;metal ion binding#GO:0046872;cation binding#GO:0043169 cellular process#GO:0009987;detoxification of inorganic compound#GO:0061687;response to stress#GO:0006950;monoatomic ion homeostasis#GO:0050801;detoxification#GO:0098754;response to chemical#GO:0042221;response to metal ion#GO:0010038;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;response to cadmium ion#GO:0046686;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;cellular response to stimulus#GO:0051716;intracellular monoatomic ion homeostasis#GO:0006873;homeostatic process#GO:0042592;response to stimulus#GO:0050896;response to toxic substance#GO:0009636;inorganic ion homeostasis#GO:0098771;cellular response to chemical stimulus#GO:0070887 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 defense/immunity protein#PC00090 HUMAN|HGNC=6216|UniProtKB=O75449 O75449 KATNA1 PTHR23074:SF71 AAA DOMAIN-CONTAINING KATANIN P60 ATPASE-CONTAINING SUBUNIT A1 macromolecular conformation isomerase activity#GO:0120543;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;isomerase activity#GO:0016853;catalytic activity, acting on a protein#GO:0140096;ATP-dependent activity#GO:0140657;polypeptide conformation or assembly isomerase activity#GO:0120544;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP hydrolysis activity#GO:0016887;hydrolase activity#GO:0016787 cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226;cytoskeleton organization#GO:0007010;microtubule-based process#GO:0007017;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987 microtubule cytoskeleton#GO:0015630;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;spindle#GO:0005819;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 non-motor microtubule binding protein#PC00166;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=544|UniProtKB=P08133 P08133 ANXA6 PTHR10502:SF19 ANNEXIN ANNEXIN A6 phosphatidylserine binding#GO:0001786;lipid binding#GO:0008289;phospholipid binding#GO:0005543;binding#GO:0005488;anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167 intracellular monoatomic ion homeostasis#GO:0006873;regulation of biological process#GO:0050789;apoptotic process#GO:0006915;response to stimulus#GO:0050896;signaling#GO:0023052;calcium ion homeostasis#GO:0055074;inorganic ion homeostasis#GO:0098771;monoatomic ion transport#GO:0006811;monoatomic ion homeostasis#GO:0050801;signal transduction#GO:0007165;cellular process#GO:0009987;chemical homeostasis#GO:0048878;intracellular calcium ion homeostasis#GO:0006874;calcium ion transport#GO:0006816;programmed cell death#GO:0012501;cellular response to stimulus#GO:0051716;cell death#GO:0008219;regulation of cellular process#GO:0050794;mitochondrial calcium ion homeostasis#GO:0051560;metal ion transport#GO:0030001;homeostatic process#GO:0042592;cell communication#GO:0007154;monoatomic cation transport#GO:0006812;localization#GO:0051179;biological regulation#GO:0065007;transport#GO:0006810;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;apoptotic signaling pathway#GO:0097190;establishment of localization#GO:0051234;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725 vesicle membrane#GO:0012506;membrane#GO:0016020;vesicle#GO:0031982;cell periphery#GO:0071944;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090 calcium-binding protein#PC00060 HUMAN|HGNC=19308|UniProtKB=Q58EX2 Q58EX2 SDK2 PTHR13817:SF59 TITIN PROTEIN SIDEKICK-2 developmental process#GO:0032502;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cell-cell adhesion#GO:0098609;cellular component biogenesis#GO:0044085;homophilic cell-cell adhesion#GO:0007156;cellular process#GO:0009987;multicellular organismal process#GO:0032501;cellular component assembly#GO:0022607;nervous system development#GO:0007399;animal gross anatomical part developmental process#GO:0160108;cell adhesion#GO:0007155;synapse organization#GO:0050808;anatomical structure development#GO:0048856;system development#GO:0048731;cellular component organization#GO:0016043;cell junction assembly#GO:0034329;cell junction organization#GO:0034330;synapse assembly#GO:0007416 cell junction#GO:0030054;synapse#GO:0045202;cellular anatomical structure#GO:0110165 structural protein#PC00211 HUMAN|HGNC=23990|UniProtKB=Q6ZMT1 Q6ZMT1 STAC2 PTHR15135:SF5 STAC SH3 AND CYSTEINE-RICH DOMAIN-CONTAINING PROTEIN 2 transporter regulator activity#GO:0141108;calcium channel regulator activity#GO:0005246;ion channel regulator activity#GO:0099106;channel regulator activity#GO:0016247;molecular function regulator activity#GO:0098772 muscle contraction#GO:0006936;regulation of localization#GO:0032879;system process#GO:0003008;regulation of protein localization to membrane#GO:1905475;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;neuromuscular process#GO:0050905;nervous system process#GO:0050877;regulation of protein localization#GO:0032880;muscle system process#GO:0003012;regulation of biological process#GO:0050789;striated muscle contraction#GO:0006941;skeletal muscle contraction#GO:0003009;regulation of cellular process#GO:0050794 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell periphery#GO:0071944;cytoplasmic side of membrane#GO:0098562;cytoplasmic side of plasma membrane#GO:0009898;membrane#GO:0016020 HUMAN|HGNC=5472|UniProtKB=P17936 P17936 IGFBP3 PTHR11551:SF3 INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 3 binding#GO:0005488;growth factor binding#GO:0019838;protein binding#GO:0005515 regulation of biological process#GO:0050789;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protein-binding activity modulator#PC00095;protease inhibitor#PC00191 p53 pathway#P00059>IGF-BP3#G04691 HUMAN|HGNC=4570|UniProtKB=Q9UBQ7 Q9UBQ7 GRHPR PTHR10996:SF137 2-HYDROXYACID DEHYDROGENASE-RELATED GLYOXYLATE REDUCTASE_HYDROXYPYRUVATE REDUCTASE catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 oxidoreductase#PC00176;dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=17849|UniProtKB=Q96PE1 Q96PE1 ADGRA2 PTHR45930:SF1 G-PROTEIN COUPLED RECEPTOR 124-LIKE PROTEIN ADHESION G PROTEIN-COUPLED RECEPTOR A2 biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;tube development#GO:0035295;positive regulation of response to stimulus#GO:0048584;multicellular organismal process#GO:0032501;positive regulation of cellular process#GO:0048522;positive regulation of canonical Wnt signaling pathway#GO:0090263;developmental process#GO:0032502;regulation of response to stimulus#GO:0048583;regulation of cell communication#GO:0010646;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;tube morphogenesis#GO:0035239;cellular response to stimulus#GO:0051716;blood vessel development#GO:0001568;positive regulation of signal transduction#GO:0009967;system development#GO:0048731;cell communication#GO:0007154;anatomical structure development#GO:0048856;nervous system development#GO:0007399;positive regulation of Wnt signaling pathway#GO:0030177;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of canonical Wnt signaling pathway#GO:0060828;anatomical structure formation involved in morphogenesis#GO:0048646;vasculature development#GO:0001944;multicellular organism development#GO:0007275;cell surface receptor signaling pathway#GO:0007166;signaling#GO:0023052;regulation of Wnt signaling pathway#GO:0030111;central nervous system development#GO:0007417;circulatory system development#GO:0072359;response to stimulus#GO:0050896;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;blood vessel morphogenesis#GO:0048514;positive regulation of signaling#GO:0023056;angiogenesis#GO:0001525;regulation of signaling#GO:0023051;sprouting angiogenesis#GO:0002040;animal gross anatomical part developmental process#GO:0160108 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021 HUMAN|HGNC=11646|UniProtKB=Q9UL49 Q9UL49 TCFL5 PTHR15402:SF3 TRANSCRIPTION FACTOR-LIKE 5 PROTEIN TRANSCRIPTION FACTOR-LIKE 5 PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HUMAN|HGNC=30869|UniProtKB=Q9UGR2 Q9UGR2 ZC3H7B PTHR14928:SF6 MICRO-RNA BINDING ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 7 ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 7B RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;gene expression#GO:0010467;RNA processing#GO:0006396;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;negative regulation of metabolic process#GO:0009892;miRNA processing#GO:0035196;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;macromolecule biosynthetic process#GO:0009059;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;negative regulation of cellular process#GO:0048523;regulatory ncRNA-mediated gene silencing#GO:0031047;regulatory ncRNA processing#GO:0070918;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;RNA biosynthetic process#GO:0032774 RNA metabolism protein#PC00031 HUMAN|HGNC=24116|UniProtKB=Q8TDP1 Q8TDP1 RNASEH2C PTHR47063:SF1 RIBONUCLEASE H2 SUBUNIT C RIBONUCLEASE H2 SUBUNIT C RNA catabolic process#GO:0006401;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;cellular process#GO:0009987;nucleic acid catabolic process#GO:0141188;nucleobase-containing compound catabolic process#GO:0034655;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;nucleobase-containing compound metabolic process#GO:0006139;catabolic process#GO:0009056 catalytic complex#GO:1902494;intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991 endoribonuclease#PC00094;RNA metabolism protein#PC00031 HUMAN|HGNC=20945|UniProtKB=Q8IUK5 Q8IUK5 PLXDC1 PTHR13055:SF10 TUMOR ENDOTHELIAL MARKER 7 RELATED PLEXIN DOMAIN-CONTAINING PROTEIN 1 HUMAN|HGNC=18418|UniProtKB=Q9NX55 Q9NX55 HYPK PTHR31184:SF2 HUNTINGTIN-INTERACTING PROTEIN K FAMILY MEMBER HUNTINGTIN-INTERACTING PROTEIN K protein stabilization#GO:0050821;regulation of biological quality#GO:0065008;regulation of apoptotic process#GO:0042981;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;negative regulation of apoptotic process#GO:0043066;negative regulation of programmed cell death#GO:0043069;regulation of biological process#GO:0050789;regulation of protein stability#GO:0031647;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067 HUMAN|HGNC=14170|UniProtKB=Q96KJ4 Q96KJ4 MSLNL PTHR23412:SF15 STEREOCILIN RELATED MESOTHELIN-LIKE PROTEIN cellular process#GO:0009987;cell adhesion#GO:0007155;cell-matrix adhesion#GO:0007160;cell-substrate adhesion#GO:0031589 cellular anatomical structure#GO:0110165;cell surface#GO:0009986 cell adhesion molecule#PC00069 HUMAN|HGNC=30553|UniProtKB=Q8IW03 Q8IW03 SIAH3 PTHR45877:SF5 E3 UBIQUITIN-PROTEIN LIGASE SIAH2 SEVEN IN ABSENTIA HOMOLOG 3 transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;binding#GO:0005488;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;enzyme binding#GO:0019899;ubiquitin-like protein transferase activity#GO:0019787;protein binding#GO:0005515;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842 protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=363|UniProtKB=P27144 P27144 AK4 PTHR23359:SF58 NUCLEOTIDE KINASE ADENYLATE KINASE 4, MITOCHONDRIAL catalytic activity#GO:0003824;transferase activity#GO:0016740;nucleobase-containing compound kinase activity#GO:0019205;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;nucleoside diphosphate kinase activity#GO:0004550;phosphotransferase activity, phosphate group as acceptor#GO:0016776 biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;nucleoside triphosphate biosynthetic process#GO:0009142;organophosphate metabolic process#GO:0019637;nucleobase-containing small molecule metabolic process#GO:0055086;purine nucleoside monophosphate metabolic process#GO:0009126;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;nucleoside phosphate metabolic process#GO:0006753;nucleoside triphosphate metabolic process#GO:0009141;purine ribonucleoside monophosphate metabolic process#GO:0009167;nucleoside monophosphate metabolic process#GO:0009123;small molecule metabolic process#GO:0044281;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;nucleotide metabolic process#GO:0009117;ribonucleotide metabolic process#GO:0009259 mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 nucleotide kinase#PC00172;kinase#PC00137 De novo purine biosynthesis#P02738>Adenylate kinase#P02896 HUMAN|HGNC=12620|UniProtKB=Q9UK80 Q9UK80 USP21 PTHR21646:SF6 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21 catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;cysteine-type deubiquitinase activity#GO:0004843;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005 regulation of protein stability#GO:0031647;biological regulation#GO:0065007;regulation of biological quality#GO:0065008 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 cysteine protease#PC00081 HUMAN|HGNC=28473|UniProtKB=Q8NC60 Q8NC60 NOA1 PTHR46406:SF1 NITRIC OXIDE-ASSOCIATED PROTEIN 1 NITRIC OXIDE-ASSOCIATED PROTEIN 1 cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cellular component assembly#GO:0022607;ribosomal small subunit biogenesis#GO:0042274;ribosomal small subunit assembly#GO:0000028;protein-RNA complex organization#GO:0071826;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;mitochondrial ribosome assembly#GO:0061668;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;ribosome assembly#GO:0042255;organelle assembly#GO:0070925;protein-RNA complex assembly#GO:0022618 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;mitochondrial inner membrane#GO:0005743;organelle envelope#GO:0031967;membrane#GO:0016020;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=6110|UniProtKB=P46940 P46940 IQGAP1 PTHR14149:SF15 RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF RAS GTPASE-ACTIVATING-LIKE PROTEIN IQGAP1 molecular function regulator activity#GO:0098772;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;cytoskeletal protein binding#GO:0008092;enzyme activator activity#GO:0008047;calmodulin binding#GO:0005516;protein-containing complex binding#GO:0044877;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;protein binding#GO:0005515;actin filament binding#GO:0051015;actin binding#GO:0003779;binding#GO:0005488 cytoskeleton-dependent cytokinesis#GO:0061640;cytokinesis#GO:0000910;cytokinetic process#GO:0032506;response to stimulus#GO:0050896;signaling#GO:0023052;actomyosin structure organization#GO:0031032;cellular component organization#GO:0016043;cell cycle process#GO:0022402;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;cell surface receptor signaling pathway#GO:0007166;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;actomyosin contractile ring assembly#GO:0000915;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;signal transduction#GO:0007165;mitotic cytokinetic process#GO:1902410;enzyme-linked receptor protein signaling pathway#GO:0007167;cortical actin cytoskeleton organization#GO:0030866;cell communication#GO:0007154;supramolecular fiber organization#GO:0097435;cortical cytoskeleton organization#GO:0030865;actin filament-based process#GO:0030029;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;mitotic cytokinesis#GO:0000281;regulation of cellular process#GO:0050794;cell motility#GO:0048870;actin cytoskeleton organization#GO:0030036;mitotic cell cycle#GO:0000278;cell cycle#GO:0007049;cellular response to stimulus#GO:0051716;cell division#GO:0051301;actin filament organization#GO:0007015;mitotic cell cycle process#GO:1903047;epidermal growth factor receptor signaling pathway#GO:0007173;cell migration#GO:0016477;biological regulation#GO:0065007;ERBB signaling pathway#GO:0038127 nucleus#GO:0005634;cell periphery#GO:0071944;cell cortex#GO:0005938;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 GTPase-activating protein#PC00257 HUMAN|HGNC=14646|UniProtKB=Q9BY78 Q9BY78 RNF26 PTHR22696:SF1 E3 UBIQUITIN-PROTEIN LIGASE RNF26 E3 UBIQUITIN-PROTEIN LIGASE RNF26 ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;cellular process#GO:0009987;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;protein modification by small protein conjugation or removal#GO:0070647;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;protein modification process#GO:0036211;primary metabolic process#GO:0044238;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=13437|UniProtKB=Q9UHP6 Q9UHP6 RSPH14 PTHR15599:SF1 RTDR1 RADIAL SPOKE HEAD 14 HOMOLOG HUMAN|HGNC=18632|UniProtKB=Q86VH2 Q86VH2 KIF27 PTHR24115:SF889 KINESIN-RELATED KINESIN-LIKE PROTEIN KIF27 binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP-dependent activity#GO:0140657;protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;hydrolase activity, acting on acid anhydrides#GO:0016817;cytoskeletal motor activity#GO:0003774;microtubule binding#GO:0008017;polypeptide conformation or assembly isomerase activity#GO:0120544;hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887;microtubule motor activity#GO:0003777;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;tubulin binding#GO:0015631;macromolecular conformation isomerase activity#GO:0120543;ribonucleoside triphosphate phosphatase activity#GO:0017111;isomerase activity#GO:0016853 cellular process#GO:0009987;microtubule-based process#GO:0007017;microtubule-based movement#GO:0007018 microtubule cytoskeleton#GO:0015630;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;microtubule#GO:0005874 microtubule or microtubule-binding cytoskeletal protein#PC00157;microtubule binding motor protein#PC00156 HUMAN|HGNC=22967|UniProtKB=P60368 P60368 KRTAP10-2 PTHR23262:SF8 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 10-2 structural protein#PC00211 HUMAN|HGNC=2737|UniProtKB=Q92771 Q92771 DDX12P PTHR11472:SF41 DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER ATP-DEPENDENT DNA HELICASE DDX11-RELATED ATP-dependent activity#GO:0140657;ATP-dependent activity, acting on DNA#GO:0008094;macromolecular conformation isomerase activity#GO:0120543;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity#GO:0003824;DNA helicase activity#GO:0003678;isomerase activity#GO:0016853;catalytic activity, acting on DNA#GO:0140097;helicase activity#GO:0004386 cell cycle process#GO:0022402;cellular process#GO:0009987;cell cycle#GO:0007049;organelle organization#GO:0006996;cellular component organization#GO:0016043;chromosome organization#GO:0051276;cellular component organization or biogenesis#GO:0071840;sister chromatid cohesion#GO:0007062 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 DNA metabolism protein#PC00009;DNA helicase#PC00011 HUMAN|HGNC=20947|UniProtKB=Q15388 Q15388 TOMM20 PTHR12430:SF2 MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM20 MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM20 HOMOLOG protein localization to mitochondrion#GO:0070585;mitochondrial transport#GO:0006839;nucleobase-containing compound transport#GO:0015931;RNA transport#GO:0050658;RNA localization#GO:0006403;protein localization to organelle#GO:0033365;establishment of RNA localization#GO:0051236;mitochondrial transmembrane transport#GO:1990542;localization#GO:0051179;transmembrane transport#GO:0055085;nucleic acid transport#GO:0050657;cellular localization#GO:0051641;protein transport#GO:0015031;macromolecule localization#GO:0033036;nitrogen compound transport#GO:0071705;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;mitochondrial protein import pathway#GO:7770058;protein import into mitochondrial matrix#GO:0030150;intracellular transport#GO:0046907;protein transmembrane import into intracellular organelle#GO:0044743;protein transmembrane transport#GO:0071806;transport#GO:0006810;intracellular protein transport#GO:0006886;establishment of protein localization to organelle#GO:0072594;intracellular protein transmembrane transport#GO:0065002;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;outer membrane#GO:0019867;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;organelle envelope#GO:0031967;membrane protein complex#GO:0098796;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;mitochondrial outer membrane#GO:0005741;mitochondrial outer membrane translocase complex#GO:0005742;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;organelle outer membrane#GO:0031968;mitochondrial protein-containing complex#GO:0098798;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;membrane#GO:0016020 transporter#PC00227;primary active transporter#PC00068 HUMAN|HGNC=4259|UniProtKB=Q9UJ14 Q9UJ14 GGT7 PTHR11686:SF54 GAMMA GLUTAMYL TRANSPEPTIDASE GLUTATHIONE HYDROLASE 7 peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;catalytic activity#GO:0003824 metabolic process#GO:0008152;glutathione metabolic process#GO:0006749;sulfur compound metabolic process#GO:0006790;modified amino acid metabolic process#GO:0006575;cellular process#GO:0009987;catabolic process#GO:0009056;sulfur compound catabolic process#GO:0044273 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 protease#PC00190;protein modifying enzyme#PC00260 HUMAN|HGNC=20079|UniProtKB=Q70EL3 Q70EL3 USP50 PTHR21646:SF11 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 50 cysteine-type deubiquitinase activity#GO:0004843;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity, acting on a protein#GO:0140096;deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787 regulation of signaling#GO:0023051;positive regulation of cellular component organization#GO:0051130;regulation of intracellular signal transduction#GO:1902531;regulation of biological quality#GO:0065008;positive regulation of signaling#GO:0023056;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;regulation of protein-containing complex assembly#GO:0043254;regulation of Wnt signaling pathway#GO:0030111;regulation of cellular component biogenesis#GO:0044087;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular component organization#GO:0051128;vesicle organization#GO:0016050;endosome organization#GO:0007032;positive regulation of response to external stimulus#GO:0032103;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;regulation of protein stability#GO:0031647;signal transduction#GO:0007165;positive regulation of immune system process#GO:0002684;regulation of canonical Wnt signaling pathway#GO:0060828;positive regulation of pattern recognition receptor signaling pathway#GO:0062208;organelle organization#GO:0006996;intracellular signaling cassette#GO:0141124;endomembrane system organization#GO:0010256;regulation of response to external stimulus#GO:0032101;positive regulation of cellular component biogenesis#GO:0044089;positive regulation of Wnt signaling pathway#GO:0030177;regulation of defense response#GO:0031347;regulation of immune response#GO:0050776;Ras protein signal transduction#GO:0007265;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;regulation of response to biotic stimulus#GO:0002831;regulation of cell communication#GO:0010646;regulation of immune system process#GO:0002682;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of defense response#GO:0031349;positive regulation of immune response#GO:0050778;regulation of response to stress#GO:0080134;positive regulation of response to biotic stimulus#GO:0002833;regulation of innate immune response#GO:0045088;positive regulation of canonical Wnt signaling pathway#GO:0090263;positive regulation of innate immune response#GO:0045089;positive regulation of cellular process#GO:0048522;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;small GTPase-mediated signal transduction#GO:0007264;positive regulation of response to stimulus#GO:0048584 cytoplasm#GO:0005737;asymmetric synapse#GO:0032279;postsynaptic specialization#GO:0099572;organelle#GO:0043226;neuron to neuron synapse#GO:0098984;cellular anatomical structure#GO:0110165;synapse#GO:0045202;cytosol#GO:0005829;postsynapse#GO:0098794;midbody#GO:0030496;intracellular anatomical structure#GO:0005622;cell junction#GO:0030054;postsynaptic density#GO:0014069 cysteine protease#PC00081 HUMAN|HGNC=15436|UniProtKB=Q9NZP2 Q9NZP2 OR6C2 PTHR26454:SF8 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 6C2 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=8168|UniProtKB=Q8NH80 Q8NH80 OR10D3 PTHR26453:SF221 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 10D3 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 detection of chemical stimulus#GO:0009593;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;response to stimulus#GO:0050896;response to chemical#GO:0042221;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;sensory perception#GO:0007600;nervous system process#GO:0050877;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|Ensembl=ENSG00000284559.2|UniProtKB=A0AAG2TCD0 A0AAG2TCD0 OTOA PTHR23412:SF18 STEREOCILIN RELATED OTOANCORIN cellular process#GO:0009987;cell adhesion#GO:0007155;cell-matrix adhesion#GO:0007160;cell-substrate adhesion#GO:0031589 cellular anatomical structure#GO:0110165;cell surface#GO:0009986 cell adhesion molecule#PC00069 HUMAN|HGNC=11217|UniProtKB=P38567 P38567 SPAM1 PTHR11769:SF20 HYALURONIDASE HYALURONIDASE PH-20 hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;catalytic activity#GO:0003824;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553 aminoglycan catabolic process#GO:0006026;macromolecule metabolic process#GO:0043170;glycosaminoglycan catabolic process#GO:0006027;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;aminoglycan metabolic process#GO:0006022;carbohydrate derivative catabolic process#GO:1901136;catabolic process#GO:0009056;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;glycosaminoglycan metabolic process#GO:0030203 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;vesicle#GO:0031982;secretory vesicle#GO:0099503;intracellular vesicle#GO:0097708;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;acrosomal vesicle#GO:0001669 glycosidase#PC00110 HUMAN|HGNC=15687|UniProtKB=O75563 O75563 SKAP2 PTHR15129:SF2 SRC-ASSOCIATED ADAPTOR PROTEIN SRC KINASE-ASSOCIATED PHOSPHOPROTEIN 2 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=7067|UniProtKB=P33076 P33076 CIITA PTHR47189:SF1 MHC CLASS II TRANSACTIVATOR MHC CLASS II TRANSACTIVATOR positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007 HUMAN|HGNC=26086|UniProtKB=Q5JRV8 Q5JRV8 TMEM255A PTHR33721:SF1 TRANSMEMBRANE PROTEIN 255B-LIKE TRANSMEMBRANE PROTEIN 255A HUMAN|HGNC=1132|UniProtKB=Q14201 Q14201 BTG3 PTHR22978:SF6 B-CELL TRANSLOCATION GENE PROTEIN BTG3 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634 HUMAN|HGNC=26292|UniProtKB=A1L3X0 A1L3X0 ELOVL7 PTHR11157:SF118 FATTY ACID ACYL TRANSFERASE-RELATED VERY LONG CHAIN FATTY ACID ELONGASE 7 acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824 lipid biosynthetic process#GO:0008610;fatty acid biosynthetic process#GO:0006633;biosynthetic process#GO:0009058;cellular process#GO:0009987;monocarboxylic acid biosynthetic process#GO:0072330;sphingolipid biosynthetic process#GO:0030148;fatty acid metabolic process#GO:0006631;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;small molecule metabolic process#GO:0044281;very long-chain fatty acid metabolic process#GO:0000038;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid biosynthetic process#GO:0046394;oxoacid metabolic process#GO:0043436 intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 acyltransferase#PC00042;transferase#PC00220 HUMAN|HGNC=7043|UniProtKB=O43451 O43451 MGAM PTHR22762:SF63 ALPHA-GLUCOSIDASE MALTASE-GLUCOAMYLASE glucosidase activity#GO:0015926;catalytic activity#GO:0003824;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;alpha-glucosidase activity#GO:0090599 glucosidase#PC00108 HUMAN|HGNC=12417|UniProtKB=P23258 P23258 TUBG1 PTHR11588:SF62 TUBULIN TUBULIN GAMMA-1 CHAIN small molecule binding#GO:0036094;anion binding#GO:0043168;ion binding#GO:0043167;nucleotide binding#GO:0000166;structural molecule activity#GO:0005198;guanyl nucleotide binding#GO:0019001;structural constituent of cytoskeleton#GO:0005200;binding#GO:0005488;nucleoside phosphate binding#GO:1901265;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;ribonucleotide binding#GO:0032553;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;carbohydrate derivative binding#GO:0097367;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555 mitotic cell cycle process#GO:1903047;chromosome organization#GO:0051276;microtubule polymerization#GO:0046785;spindle organization#GO:0007051;microtubule polymerization or depolymerization#GO:0031109;mitotic sister chromatid segregation#GO:0000070;sexual reproduction#GO:0019953;supramolecular fiber organization#GO:0097435;organelle fission#GO:0048285;microtubule cytoskeleton organization#GO:0000226;cell cycle#GO:0007049;microtubule cytoskeleton organization involved in mitosis#GO:1902850;reproductive process#GO:0022414;mitotic cell cycle#GO:0000278;chromosome segregation#GO:0007059;meiotic cell cycle#GO:0051321;protein-containing complex organization#GO:0043933;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;nuclear division#GO:0000280;protein polymerization#GO:0051258;protein-containing complex assembly#GO:0065003;mitotic nuclear division#GO:0140014;cell cycle process#GO:0022402;microtubule nucleation#GO:0007020;sister chromatid segregation#GO:0000819;nuclear chromosome segregation#GO:0098813;cellular component organization#GO:0016043;meiotic cell cycle process#GO:1903046;mitotic spindle organization#GO:0007052 intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;nucleus#GO:0005634;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;centrosome#GO:0005813;microtubule organizing center#GO:0005815;spindle#GO:0005819;cytoskeleton#GO:0005856;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;intracellular organelle#GO:0043229 tubulin#PC00228;cytoskeletal protein#PC00085 HUMAN|HGNC=7872|UniProtKB=P29475 P29475 NOS1 PTHR19384:SF63 NITRIC OXIDE SYNTHASE-RELATED NITRIC OXIDE SYNTHASE 1 ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;oxidoreductase activity#GO:0016491;nucleotide binding#GO:0000166;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen#GO:0016709;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;oxidoreductase activity, acting on NAD(P)H#GO:0016651;nucleoside phosphate binding#GO:1901265;flavin adenine dinucleotide binding#GO:0050660;binding#GO:0005488;heterocyclic compound binding#GO:1901363;carbohydrate derivative binding#GO:0097367;monooxygenase activity#GO:0004497;ribonucleotide binding#GO:0032553 small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;small molecule catabolic process#GO:0044282;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;carboxylic acid metabolic process#GO:0019752;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;response to molecule of bacterial origin#GO:0002237;regulation of biological quality#GO:0065008;oxoacid metabolic process#GO:0043436;response to oxygen-containing compound#GO:1901700;response to lipid#GO:0033993;response to chemical#GO:0042221;arginine metabolic process#GO:0006525;intracellular signaling cassette#GO:0141124;response to hormone#GO:0009725;response to biotic stimulus#GO:0009607;cellular process#GO:0009987;signal transduction#GO:0007165;response to lipopolysaccharide#GO:0032496;metabolic process#GO:0008152;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;response to external biotic stimulus#GO:0043207;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;circulatory system process#GO:0003013;response to bacterium#GO:0009617;proteinogenic amino acid metabolic process#GO:0170039;multicellular organismal process#GO:0032501;blood circulation#GO:0008015;amino acid metabolic process#GO:0006520;response to other organism#GO:0051707;biological regulation#GO:0065007;biosynthetic process#GO:0009058;regulation of blood pressure#GO:0008217;carboxylic acid catabolic process#GO:0046395;response to external stimulus#GO:0009605;system process#GO:0003008 postsynapse#GO:0098794;organelle#GO:0043226;asymmetric synapse#GO:0032279;cellular anatomical structure#GO:0110165;synapse#GO:0045202;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;postsynaptic density#GO:0014069;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;membrane#GO:0016020;cell periphery#GO:0071944;nucleus#GO:0005634;postsynaptic specialization#GO:0099572;neuron to neuron synapse#GO:0098984;plasma membrane#GO:0005886;cytoplasm#GO:0005737;cell junction#GO:0030054 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 Gonadotropin-releasing hormone receptor pathway#P06664>NOSI#G06888;Gonadotropin-releasing hormone receptor pathway#P06664>NOSI#P06741;CCKR signaling map#P06959>NOS1#P07158 HUMAN|HGNC=8568|UniProtKB=P09958 P09958 FURIN PTHR42884:SF1 PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED FURIN catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171 proteolysis#GO:0006508;protein metabolic process#GO:0019538;signaling receptor ligand precursor processing#GO:0140448;regulation of biological quality#GO:0065008;primary metabolic process#GO:0044238;regulation of hormone levels#GO:0010817;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;peptide hormone processing#GO:0016486;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein processing#GO:0016485;protein maturation#GO:0051604;gene expression#GO:0010467;hormone metabolic process#GO:0042445;biosynthetic process#GO:0009058;biological regulation#GO:0065007 membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;endomembrane system#GO:0012505;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020 serine protease#PC00203 Alzheimer disease-amyloid secretase pathway#P00003>Furin#P00105;Alzheimer disease-presenilin pathway#P00004>Furin#P00157;Endothelin signaling pathway#P00019>furin#P00575 HUMAN|HGNC=12379|UniProtKB=Q15631 Q15631 TSN PTHR10741:SF2 TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X TRANSLIN nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=19261|UniProtKB=Q9Y2Z2 Q9Y2Z2 MTO1 PTHR11806:SF4 GLUCOSE INHIBITED DIVISION PROTEIN A 5-TAURINOMETHYLURIDINE-[TRNA] SYNTHASE SUBUNIT MTO1, MITOCHONDRIAL catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098 mitochondrial RNA modification#GO:1900864;RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;mitochondrial RNA metabolic process#GO:0000959;mitochondrial gene expression#GO:0140053;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;tRNA wobble base modification#GO:0002097;tRNA wobble uridine modification#GO:0002098;tRNA modification#GO:0006400;RNA biosynthetic process#GO:0032774;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;mitochondrial RNA processing#GO:0000963;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396 catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=26781|UniProtKB=Q8N112 Q8N112 LSMEM2 PTHR37333:SF1 LEUCINE-RICH SINGLE-PASS MEMBRANE PROTEIN 2 LEUCINE-RICH SINGLE-PASS MEMBRANE PROTEIN 2 HUMAN|HGNC=30916|UniProtKB=Q8TEU8 Q8TEU8 WFIKKN2 PTHR45938:SF7 ACP24A4-RELATED WAP, KAZAL, IMMUNOGLOBULIN, KUNITZ AND NTR DOMAIN-CONTAINING PROTEIN 2 signaling receptor inhibitor activity#GO:0030547;molecular function inhibitor activity#GO:0140678;growth factor binding#GO:0019838;protein binding#GO:0005515;binding#GO:0005488;cytokine binding#GO:0019955;molecular function regulator activity#GO:0098772;transforming growth factor beta binding#GO:0050431;signaling receptor regulator activity#GO:0030545 cell surface receptor signaling pathway#GO:0007166;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;biological regulation#GO:0065007;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;cellular process#GO:0009987;signal transduction#GO:0007165;transforming growth factor beta receptor signaling pathway#GO:0007179;cellular response to growth factor stimulus#GO:0071363;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;response to transforming growth factor beta#GO:0071559;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to growth factor#GO:0070848;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;cellular response to transforming growth factor beta stimulus#GO:0071560;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=23019|UniProtKB=Q15696 Q15696 ZRSR2 PTHR12620:SF38 U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT U2 SMALL NUCLEAR RIBONUCLEOPROTEIN AUXILIARY FACTOR 35 KDA SUBUNIT-RELATED PROTEIN 2 binding#GO:0005488;nucleic acid binding#GO:0003676;pre-mRNA binding#GO:0036002;RNA binding#GO:0003723 mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 RNA splicing factor#PC00148 mRNA splicing#P00058>U2AF65#P01475 HUMAN|HGNC=17923|UniProtKB=Q9NZI5 Q9NZI5 GRHL1 PTHR11037:SF16 TRANSCRIPTION FACTOR CP2 GRAINYHEAD-LIKE PROTEIN 1 HOMOLOG transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;DNA-binding transcription activator activity#GO:0001216;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific double-stranded DNA binding#GO:1990837 regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218 HUMAN|HGNC=10387|UniProtKB=P62263 P62263 RPS14 PTHR11759:SF72 40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11 SMALL RIBOSOMAL SUBUNIT PROTEIN US11 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 metabolic process#GO:0008152;ribosomal small subunit biogenesis#GO:0042274;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-RNA complex organization#GO:0071826;ribosomal small subunit assembly#GO:0000028;protein-containing complex organization#GO:0043933;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component assembly#GO:0022607;gene expression#GO:0010467;biosynthetic process#GO:0009058;ribosome assembly#GO:0042255;organelle assembly#GO:0070925;ribosome biogenesis#GO:0042254;translation#GO:0006412;protein metabolic process#GO:0019538;protein-RNA complex assembly#GO:0022618;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;primary metabolic process#GO:0044238;protein-containing complex assembly#GO:0065003;protein biosynthetic process#GO:0160307;ribonucleoprotein complex biogenesis#GO:0022613 ribosome#GO:0005840;cytosolic ribosome#GO:0022626;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular organelle#GO:0043229;small ribosomal subunit#GO:0015935;cytosolic small ribosomal subunit#GO:0022627;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 ribosomal protein#PC00202;translational protein#PC00263 HUMAN|HGNC=15280|UniProtKB=Q8NGL4 Q8NGL4 OR5D13 PTHR48018:SF33 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5D13 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 multicellular organismal process#GO:0032501;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606;sensory perception of smell#GO:0007608;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;nervous system process#GO:0050877;sensory perception#GO:0007600 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=4587|UniProtKB=Q14957 Q14957 GRIN2C PTHR18966:SF361 IONOTROPIC GLUTAMATE RECEPTOR GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2C molecular transducer activity#GO:0060089;channel activity#GO:0015267;carboxylic acid transmembrane transporter activity#GO:0046943;ligand-gated monoatomic ion channel activity#GO:0015276;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;dicarboxylic acid transmembrane transporter activity#GO:0005310;passive transmembrane transporter activity#GO:0022803;glutamate receptor activity#GO:0008066;ligand-gated channel activity#GO:0022834;transmembrane transporter activity#GO:0022857;voltage-gated channel activity#GO:0022832;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;transmembrane signaling receptor activity#GO:0004888;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;signaling receptor activity#GO:0038023;neurotransmitter receptor activity#GO:0030594;amino acid transmembrane transporter activity#GO:0015171;transporter activity#GO:0005215 positive regulation of synaptic transmission#GO:0050806;nervous system process#GO:0050877;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;regulation of biological quality#GO:0065008;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signaling#GO:0023052;cell surface receptor signaling pathway#GO:0007166;regulation of membrane potential#GO:0042391;synaptic signaling#GO:0099536;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;regulation of trans-synaptic signaling#GO:0099177;synaptic transmission, glutamatergic#GO:0035249;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;chemical synaptic transmission#GO:0007268;cellular response to stimulus#GO:0051716;regulation of postsynaptic membrane potential#GO:0060078;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;anterograde trans-synaptic signaling#GO:0098916;chemical synaptic transmission, postsynaptic#GO:0099565;regulation of cell communication#GO:0010646;modulation of chemical synaptic transmission#GO:0050804;regulation of synaptic plasticity#GO:0048167;system process#GO:0003008;positive regulation of cellular process#GO:0048522;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;cell-cell signaling#GO:0007267 synaptic membrane#GO:0097060;signaling receptor complex#GO:0043235;transporter complex#GO:1990351;cell junction#GO:0030054;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;neuron to neuron synapse#GO:0098984;monoatomic ion channel complex#GO:0034702;plasma membrane region#GO:0098590;postsynaptic specialization#GO:0099572;postsynaptic density#GO:0014069;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;postsynaptic density membrane#GO:0098839;transmembrane transporter complex#GO:1902495;plasma membrane protein complex#GO:0098797;postsynapse#GO:0098794;membrane protein complex#GO:0098796;cellular anatomical structure#GO:0110165;synapse#GO:0045202;asymmetric synapse#GO:0032279;organelle#GO:0043226 transmembrane signal receptor#PC00197 Ionotropic glutamate receptor pathway#P00037>NR2C#P01006;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>NMDA#P01071;Ionotropic glutamate receptor pathway#P00037>NMDA#P01024;Metabotropic glutamate receptor group I pathway#P00041>NMDA#P01060;Huntington disease#P00029>NMDA receptor#P00778;Metabotropic glutamate receptor group III pathway#P00039>NMDA#P01039 HUMAN|HGNC=10968|UniProtKB=Q9H015 Q9H015 SLC22A4 PTHR24064:SF222 SOLUTE CARRIER FAMILY 22 MEMBER SOLUTE CARRIER FAMILY 22 MEMBER 4 quaternary ammonium group transmembrane transporter activity#GO:0015651;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;cellular process#GO:0009987;transport#GO:0006810;nitrogen compound transport#GO:0071705;quaternary ammonium group transport#GO:0015697 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 secondary carrier transporter#PC00258 HUMAN|HGNC=25499|UniProtKB=Q9NW75 Q9NW75 GPATCH2 PTHR14195:SF4 G PATCH DOMAIN CONTAINING PROTEIN 2 G PATCH DOMAIN-CONTAINING PROTEIN 2 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031 HUMAN|HGNC=4717|UniProtKB=P16402 P16402 H1-3 PTHR11467:SF137 HISTONE H1 HISTONE H1.3 protein-containing complex binding#GO:0044877;nucleosome binding#GO:0031491;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;chromatin binding#GO:0003682;nucleic acid binding#GO:0003676;binding#GO:0005488;chromatin DNA binding#GO:0031490 negative regulation of cellular process#GO:0048523;chromosome organization#GO:0051276;cellular component organization or biogenesis#GO:0071840;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;organelle organization#GO:0006996;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;negative regulation of DNA metabolic process#GO:0051053;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of DNA recombination#GO:0000018;chromosome condensation#GO:0030261;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of biological process#GO:0050789;regulation of DNA metabolic process#GO:0051052;negative regulation of biological process#GO:0048519;negative regulation of DNA recombination#GO:0045910;cellular component organization#GO:0016043;negative regulation of metabolic process#GO:0009892;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=6015|UniProtKB=P24394 P24394 IL4R PTHR23037:SF32 CYTOKINE RECEPTOR INTERLEUKIN-4 RECEPTOR SUBUNIT ALPHA transmembrane signaling receptor activity#GO:0004888;cytokine receptor activity#GO:0004896;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;immune receptor activity#GO:0140375 response to peptide#GO:1901652;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;cytokine-mediated signaling pathway#GO:0019221;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to chemical#GO:0042221;response to stimulus#GO:0050896;response to cytokine#GO:0034097;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;signal transduction#GO:0007165 cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020;plasma membrane#GO:0005886;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552 transmembrane signal receptor#PC00197 Interleukin signaling pathway#P00036>Receptor subunit alpha#P00992 HUMAN|HGNC=7571|UniProtKB=Q9UKX3 Q9UKX3 MYH13 PTHR45615:SF44 MYOSIN HEAVY CHAIN, NON-MUSCLE MYOSIN-13 ATP-dependent activity#GO:0140657;actin binding#GO:0003779;actin filament binding#GO:0051015;polypeptide conformation or assembly isomerase activity#GO:0120544;binding#GO:0005488;protein-containing complex binding#GO:0044877;protein binding#GO:0005515;macromolecular conformation isomerase activity#GO:0120543;cytoskeletal protein binding#GO:0008092;catalytic activity#GO:0003824;microfilament motor activity#GO:0000146;isomerase activity#GO:0016853;cytoskeletal motor activity#GO:0003774 multicellular organismal process#GO:0032501;system process#GO:0003008;muscle contraction#GO:0006936;muscle system process#GO:0003012 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membraneless organelle#GO:0043228;actin cytoskeleton#GO:0015629;myosin complex#GO:0016459;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;organelle#GO:0043226;supramolecular complex#GO:0099080 actin or actin-binding cytoskeletal protein#PC00041 Wnt signaling pathway#P00057>NFAT Target Genes#G01559;Cytoskeletal regulation by Rho GTPase#P00016>Myosin#P00522;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Myosin#P00867;Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HUMAN|HGNC=3029|UniProtKB=Q9Y295 Q9Y295 DRG1 PTHR43127:SF1 DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2 DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 1 purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;nucleotide binding#GO:0000166;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;small molecule binding#GO:0036094;binding#GO:0005488;anion binding#GO:0043168;ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265;guanyl nucleotide binding#GO:0019001 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;cytoplasmic translation#GO:0002181;translation#GO:0006412;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=24145|UniProtKB=Q96RP7 Q96RP7 GAL3ST4 PTHR14647:SF57 GALACTOSE-3-O-SULFOTRANSFERASE GALACTOSE-3-O-SULFOTRANSFERASE 4 catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring sulphur-containing groups#GO:0016782;sulfotransferase activity#GO:0008146 transferase#PC00220 HUMAN|HGNC=12730|UniProtKB=Q9UGM6 Q9UGM6 WARS2 PTHR43766:SF5 TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL ligase activity#GO:0016874;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098 mitochondrial gene expression#GO:0140053;protein metabolic process#GO:0019538;RNA metabolic process#GO:0016070;mitochondrial RNA metabolic process#GO:0000959;translation#GO:0006412;protein biosynthetic process#GO:0160307;mitochondrial translation#GO:0032543;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;amino acid activation#GO:0043038;macromolecule metabolic process#GO:0043170;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;amino acid metabolic process#GO:0006520;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;tRNA aminoacylation for protein translation#GO:0006418;tRNA aminoacylation#GO:0043039 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974 aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 HUMAN|HGNC=18432|UniProtKB=Q96PC5 Q96PC5 MIA2 PTHR23158:SF38 MELANOMA INHIBITORY ACTIVITY-RELATED MELANOMA INHIBITORY ACTIVITY PROTEIN 2 vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;macromolecule localization#GO:0033036;establishment of protein localization to extracellular region#GO:0035592;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;transport#GO:0006810;Golgi vesicle transport#GO:0048193;intracellular transport#GO:0046907;export from cell#GO:0140352;protein localization to extracellular region#GO:0071692;protein transport#GO:0015031;secretion by cell#GO:0032940;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;secretion#GO:0046903;cellular localization#GO:0051641;protein secretion#GO:0009306;localization#GO:0051179 endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endoplasmic reticulum exit site#GO:0070971;organelle membrane#GO:0031090;membrane#GO:0016020;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 membrane traffic protein#PC00150 HUMAN|HGNC=17700|UniProtKB=Q9NRJ3 Q9NRJ3 CCL28 PTHR12015:SF205 SMALL INDUCIBLE CYTOKINE A C-C MOTIF CHEMOKINE 28 cytokine#PC00083 HUMAN|HGNC=2038|UniProtKB=P56750 P56750 CLDN17 PTHR12002:SF75 CLAUDIN CLAUDIN-17 paracellular tight junction channel activity#GO:0160187;transporter activity#GO:0005215 cellular component assembly#GO:0022607;cell junction organization#GO:0034330;cell junction assembly#GO:0034329;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;cellular process#GO:0009987;paracellular transport#GO:0160184;cellular component organization or biogenesis#GO:0071840;localization#GO:0051179;establishment of localization#GO:0051234;cell-cell junction organization#GO:0045216;transport#GO:0006810;cell-cell junction assembly#GO:0007043 anchoring junction#GO:0070161;cell junction#GO:0030054;tight junction#GO:0070160;apical junction complex#GO:0043296;plasma membrane#GO:0005886;bicellular tight junction#GO:0005923;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;cell-cell junction#GO:0005911 cell junction protein#PC00070;tight junction#PC00214 HUMAN|HGNC=12032|UniProtKB=Q12933 Q12933 TRAF2 PTHR10131:SF21 TNF RECEPTOR ASSOCIATED FACTOR TNF RECEPTOR-ASSOCIATED FACTOR 2 ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;protein-macromolecule adaptor activity#GO:0030674;signaling receptor binding#GO:0005102;cytokine receptor binding#GO:0005126;binding#GO:0005488;ubiquitin-protein transferase activity#GO:0004842;protein binding#GO:0005515;signaling adaptor activity#GO:0035591;molecular adaptor activity#GO:0060090;catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;tumor necrosis factor receptor superfamily binding#GO:0032813 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;signaling#GO:0023052;regulation of cell communication#GO:0010646;positive regulation of signal transduction#GO:0009967;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;tumor necrosis factor-mediated signaling pathway#GO:0033209;positive regulation of signaling#GO:0023056;response to peptide#GO:1901652;cytokine-mediated signaling pathway#GO:0019221;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;response to cytokine#GO:0034097;positive regulation of response to stimulus#GO:0048584;response to chemical#GO:0042221;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;response to tumor necrosis factor#GO:0034612;positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of canonical NF-kappaB signal transduction#GO:0043122;positive regulation of canonical NF-kappaB signal transduction#GO:0043123;positive regulation of intracellular signal transduction#GO:1902533;cell surface receptor signaling pathway#GO:0007166;regulation of response to stimulus#GO:0048583 membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;endoplasmic reticulum protein-containing complex#GO:0140534;organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasm#GO:0005737;membrane#GO:0016020 scaffold/adaptor protein#PC00226 p53 pathway#P00059>TRAF#P04620;Apoptosis signaling pathway#P00006>TRAF2#P00306 HUMAN|HGNC=33997|UniProtKB=A0A075B759 A0A075B759 PPIAL4E PTHR11071:SF466 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A-LIKE 4C-RELATED organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 chaperone#PC00072 HUMAN|HGNC=25064|UniProtKB=Q0VFZ6 Q0VFZ6 CFAP210 PTHR28663:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 173 CILIA- AND FLAGELLA- ASSOCIATED PROTEIN 210 microtubule#GO:0005874;axoneme#GO:0005930;membrane-bounded organelle#GO:0043227;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cilium#GO:0005929;organelle#GO:0043226;cellular anatomical structure#GO:0110165;axonemal microtubule#GO:0005879;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cytoplasmic microtubule#GO:0005881;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cytoskeleton#GO:0005856;supramolecular complex#GO:0099080;ciliary plasm#GO:0097014;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630 HUMAN|HGNC=21690|UniProtKB=Q7L5D6 Q7L5D6 GET4 PTHR12875:SF3 GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG molecular carrier activity#GO:0140104;protein carrier activity#GO:0140597 cellular process#GO:0009987;establishment of protein localization#GO:0045184;organelle organization#GO:0006996;establishment of protein localization to membrane#GO:0090150;macromolecule localization#GO:0033036;membrane organization#GO:0061024;endomembrane system organization#GO:0010256;protein insertion into membrane#GO:0051205;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;endoplasmic reticulum organization#GO:0007029;protein insertion into ER membrane#GO:0045048;cellular component organization#GO:0016043;protein localization to organelle#GO:0033365;localization within membrane#GO:0051668;cellular localization#GO:0051641;localization#GO:0051179 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 HUMAN|HGNC=25791|UniProtKB=Q8IXW5 Q8IXW5 RPAP2 PTHR14732:SF0 RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721;protein serine/threonine phosphatase activity#GO:0004722 macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;RNA metabolic process#GO:0016070;snRNA metabolic process#GO:0016073;nucleic acid biosynthetic process#GO:0141187;snRNA transcription#GO:0009301;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 protein phosphatase#PC00195 HUMAN|HGNC=33131|UniProtKB=Q6NUJ1 Q6NUJ1 PSAPL1 PTHR11480:SF39 SAPOSIN-RELATED PROACTIVATOR POLYPEPTIDE-LIKE 1 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cell communication#GO:0007154;regulation of lipid metabolic process#GO:0019216;G protein-coupled receptor signaling pathway#GO:0007186;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;signal transduction#GO:0007165;adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway#GO:0007193;metabolic process#GO:0008152;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;lipid metabolic process#GO:0006629 scaffold/adaptor protein#PC00226 HUMAN|HGNC=16725|UniProtKB=Q86X45 Q86X45 DNAAF11 PTHR18849:SF21 LEUCINE RICH REPEAT PROTEIN DYNEIN AXONEMAL ASSEMBLY FACTOR 11 plasma membrane bounded cell projection assembly#GO:0120031;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;microtubule-based process#GO:0007017;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;outer dynein arm assembly#GO:0036158;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton organization#GO:0007010;organelle assembly#GO:0070925;axonemal dynein complex assembly#GO:0070286;microtubule bundle formation#GO:0001578;microtubule cytoskeleton organization#GO:0000226;cilium organization#GO:0044782;axoneme assembly#GO:0035082;cellular component organization#GO:0016043;cilium assembly#GO:0060271;protein-containing complex assembly#GO:0065003;cell projection organization#GO:0030030 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=19139|UniProtKB=Q8WZA1 Q8WZA1 POMGNT1 PTHR46396:SF1 PROTEIN O-LINKED-MANNOSE BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE 1 PROTEIN O-LINKED-MANNOSE BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE 1 hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740;acetylglucosaminyltransferase activity#GO:0008375;UDP-glycosyltransferase activity#GO:0008194;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757 biosynthetic process#GO:0009058;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;protein O-linked glycosylation#GO:0006493;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020 protein modifying enzyme#PC00260 HUMAN|HGNC=23326|UniProtKB=Q7Z7A4 Q7Z7A4 PXK PTHR22999:SF40 PX SERINE/THREONINE KINASE PXK PX DOMAIN-CONTAINING PROTEIN KINASE-LIKE PROTEIN regulation of biological process#GO:0050789;regulation of signaling#GO:0023051;biological regulation#GO:0065007;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of trans-synaptic signaling#GO:0099177 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HUMAN|HGNC=10964|UniProtKB=Q96BI1 Q96BI1 SLC67A1 PTHR24002:SF5 SOLUTE CARRIER FAMILY 22 MEMBER 18 SOLUTE CARRIER FAMILY 67 MEMBER A1 export from cell#GO:0140352;detoxification#GO:0098754;response to toxic substance#GO:0009636;response to chemical#GO:0042221;response to stimulus#GO:0050896;cellular process#GO:0009987;xenobiotic detoxification by transmembrane export across the plasma membrane#GO:1990961;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810;xenobiotic transport#GO:0042908 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;organelle envelope#GO:0031967;nucleus#GO:0005634 secondary carrier transporter#PC00258 HUMAN|HGNC=25032|UniProtKB=Q8WW52 Q8WW52 FAM151A PTHR21184:SF4 MENORIN (DENDRITIC BRANCHING PROTEIN) PROTEIN FAM151A extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=17018|UniProtKB=Q9Y6Y8 Q9Y6Y8 SEC23IP PTHR23509:SF4 PA-PL1 PHOSPHOLIPASE FAMILY SEC23-INTERACTING PROTEIN hydrolase activity#GO:0016787;phospholipase activity#GO:0120569;hydrolase activity, acting on ester bonds#GO:0016788;lipase activity#GO:0016298;catalytic activity#GO:0003824;glycerophospholipase activity#GO:0004620 cellular developmental process#GO:0048869;spermatogenesis#GO:0007283;developmental process#GO:0032502;male gamete generation#GO:0048232;cellular process#GO:0009987;multicellular organismal reproductive process#GO:0048609;anatomical structure development#GO:0048856;spermatid development#GO:0007286;sexual reproduction#GO:0019953;spermatid differentiation#GO:0048515;reproductive process#GO:0022414;cell development#GO:0048468;cellular process involved in reproduction in multicellular organism#GO:0022412;gamete generation#GO:0007276;cell differentiation#GO:0030154;germ cell development#GO:0007281;developmental process involved in reproduction#GO:0003006 COPII-coated ER to Golgi transport vesicle#GO:0030134;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;coated vesicle#GO:0030135;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular vesicle#GO:0097708;vesicle#GO:0031982 phospholipase#PC00186;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=11835|UniProtKB=P51854 P51854 TKTL1 PTHR43195:SF2 TRANSKETOLASE TRANSKETOLASE-LIKE PROTEIN 1 transketolase or transaldolase activity#GO:0016744;catalytic activity#GO:0003824;transferase activity#GO:0016740;heterocyclic compound binding#GO:1901363;binding#GO:0005488;anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167;cation binding#GO:0043169;transketolase activity#GO:0004802 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;transketolase#PC00221 HUMAN|HGNC=8804|UniProtKB=P09619 P09619 PDGFRB PTHR24416:SF53 TYROSINE-PROTEIN KINASE RECEPTOR PLATELET-DERIVED GROWTH FACTOR RECEPTOR BETA molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714;catalytic activity, acting on a protein#GO:0140096;transmembrane receptor protein kinase activity#GO:0019199;protein tyrosine kinase activity#GO:0004713;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein binding#GO:0005515;phosphotransferase activity, alcohol group as acceptor#GO:0016773;growth factor binding#GO:0019838;protein kinase activity#GO:0004672;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;transferase activity#GO:0016740;kinase activity#GO:0016301 animal gross anatomical part developmental process#GO:0160108;cellular response to chemical stimulus#GO:0070887;angiogenesis#GO:0001525;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;blood vessel morphogenesis#GO:0048514;positive regulation of cell motility#GO:2000147;positive regulation of cell population proliferation#GO:0008284;signaling#GO:0023052;circulatory system development#GO:0072359;response to stimulus#GO:0050896;cell surface receptor signaling pathway#GO:0007166;vasculature development#GO:0001944;anatomical structure formation involved in morphogenesis#GO:0048646;multicellular organism development#GO:0007275;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;response to chemical#GO:0042221;taxis#GO:0042330;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;chemotaxis#GO:0006935;cell chemotaxis#GO:0060326;system development#GO:0048731;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of cell motility#GO:2000145;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;tube morphogenesis#GO:0035239;blood vessel development#GO:0001568;cellular response to stimulus#GO:0051716;locomotion#GO:0040011;regulation of cellular process#GO:0050794;cell motility#GO:0048870;developmental process#GO:0032502;regulation of cell migration#GO:0030334;positive regulation of locomotion#GO:0040017;response to external stimulus#GO:0009605;positive regulation of cell migration#GO:0030335;positive regulation of cellular process#GO:0048522;tube development#GO:0035295;regulation of locomotion#GO:0040012;biological regulation#GO:0065007;cell migration#GO:0016477;multicellular organismal process#GO:0032501 signaling receptor complex#GO:0043235;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 transmembrane signal receptor#PC00197 PDGF signaling pathway#P00047>PDGF receptor B#P01156;Angiogenesis#P00005>PDGFR#P00230 HUMAN|HGNC=30714|UniProtKB=Q8NCV1 Q8NCV1 ADAD2 PTHR10910:SF106 EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN ADENOSINE DEAMINASE DOMAIN-CONTAINING PROTEIN 2 double-stranded RNA binding#GO:0003725;tRNA-specific adenosine deaminase activity#GO:0008251;binding#GO:0005488;nucleic acid binding#GO:0003676;adenosine deaminase activity#GO:0004000;catalytic activity, acting on a tRNA#GO:0140101;hydrolase activity#GO:0016787;RNA binding#GO:0003723;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;deaminase activity#GO:0019239;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;adenosine to inosine editing#GO:0006382;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;base conversion or substitution editing#GO:0016553;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634 RNA metabolism protein#PC00031 HUMAN|HGNC=26042|UniProtKB=Q9NX00 Q9NX00 TMEM160 PTHR16236:SF0 TRANSMEMBRANE PROTEIN 160 TRANSMEMBRANE PROTEIN 160 HUMAN|HGNC=20834|UniProtKB=Q86V35 Q86V35 CABP7 PTHR46311:SF1 CALCIUM-BINDING PROTEIN 8-RELATED CALCIUM-BINDING PROTEIN 7 intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;endomembrane system#GO:0012505;trans-Golgi network membrane#GO:0032588;cellular anatomical structure#GO:0110165;organelle#GO:0043226;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020 HUMAN|HGNC=18783|UniProtKB=Q02040 Q02040 AKAP17A PTHR12484:SF2 B-LYMPHOCYTE ANTIGEN-RELATED A-KINASE ANCHOR PROTEIN 17A protein binding#GO:0005515;binding#GO:0005488;protein kinase A binding#GO:0051018 regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 nuclear speck#GO:0016607;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;nuclear body#GO:0016604;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;membraneless organelle#GO:0043228 HUMAN|HGNC=4937|UniProtKB=P13765 P13765 HLA-DOB PTHR19944:SF43 MHC CLASS II-RELATED HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DO BETA CHAIN binding#GO:0005488;peptide binding#GO:0042277;antigen binding#GO:0003823;protein-containing complex binding#GO:0044877 positive regulation of cell activation#GO:0050867;positive regulation of leukocyte cell-cell adhesion#GO:1903039;biological regulation#GO:0065007;regulation of cell adhesion#GO:0030155;positive regulation of response to stimulus#GO:0048584;positive regulation of cellular process#GO:0048522;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;regulation of leukocyte cell-cell adhesion#GO:1903037;regulation of cell-cell adhesion#GO:0022407;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;positive regulation of cell adhesion#GO:0045785;antigen processing and presentation#GO:0019882;positive regulation of lymphocyte activation#GO:0051251;regulation of immune response#GO:0050776;regulation of multicellular organismal process#GO:0051239;regulation of T cell activation#GO:0050863;positive regulation of T cell activation#GO:0050870;cellular component assembly#GO:0022607;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of immune system process#GO:0002684;positive regulation of cell-cell adhesion#GO:0022409;cellular component biogenesis#GO:0044085;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;positive regulation of leukocyte activation#GO:0002696;regulation of lymphocyte activation#GO:0051249;positive regulation of multicellular organismal process#GO:0051240;regulation of cell activation#GO:0050865;regulation of biological process#GO:0050789;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;regulation of leukocyte activation#GO:0002694;immune system process#GO:0002376 plasma membrane protein complex#GO:0098797;lysosome#GO:0005764;vesicle#GO:0031982;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;lytic vacuole membrane#GO:0098852;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;endosome membrane#GO:0010008;endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;lysosomal membrane#GO:0005765;cell periphery#GO:0071944;membrane#GO:0016020;vesicle membrane#GO:0012506;cytoplasm#GO:0005737;plasma membrane#GO:0005886;vacuole#GO:0005773;protein-containing complex#GO:0032991;late endosome#GO:0005770;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;late endosome membrane#GO:0031902;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;vacuolar membrane#GO:0005774;lytic vacuole#GO:0000323 major histocompatibility complex protein#PC00149 HUMAN|HGNC=17897|UniProtKB=O75691 O75691 UTP20 PTHR17695:SF11 SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;maturation of SSU-rRNA#GO:0030490;gene expression#GO:0010467;endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000480;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000479;cellular component biogenesis#GO:0044085;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;ribosomal small subunit biogenesis#GO:0042274;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152 small-subunit processome#GO:0032040;organelle lumen#GO:0043233;90S preribosome#GO:0030686;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;preribosome#GO:0030684;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228 HUMAN|HGNC=9763|UniProtKB=P61019 P61019 RAB2A PTHR47979:SF12 DRAB11-RELATED RAS-RELATED PROTEIN RAB-2A nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;ion binding#GO:0043167;GTPase activity#GO:0003924;small molecule binding#GO:0036094;anion binding#GO:0043168;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;guanyl nucleotide binding#GO:0019001 vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810;cellular process#GO:0009987 membrane-bounded organelle#GO:0043227;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020 small GTPase#PC00208;G-protein#PC00020 HUMAN|Ensembl=ENSG00000278082.3|UniProtKB=A0A0J9YWU9 A0A0J9YWU9 PTHR23266:SF323 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 4-30-2-RELATED antigen binding#GO:0003823;binding#GO:0005488 immunoglobulin mediated immune response#GO:0016064;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;immune effector process#GO:0002252;immune system process#GO:0002376;adaptive immune response#GO:0002250;response to stimulus#GO:0050896;immune response#GO:0006955 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=30781|UniProtKB=Q86TJ2 Q86TJ2 TADA2B PTHR12374:SF63 TRANSCRIPTIONAL ADAPTOR 2 ADA2 -RELATED TRANSCRIPTIONAL ADAPTER 2-BETA transcription coactivator activity#GO:0003713;binding#GO:0005488;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;chromatin binding#GO:0003682 regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;chromatin remodeling#GO:0006338;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;chromatin organization#GO:0006325;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;acetyltransferase complex#GO:1902493;SAGA-type complex#GO:0070461;protein acetyltransferase complex#GO:0031248;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;chromosome#GO:0005694;intracellular protein-containing complex#GO:0140535;histone acetyltransferase complex#GO:0000123;membraneless organelle#GO:0043228;transferase complex#GO:1990234;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;chromatin#GO:0000785;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=13357|UniProtKB=Q8IZK6 Q8IZK6 MCOLN2 PTHR12127:SF4 MUCOLIPIN MUCOLIPIN-2 gated channel activity#GO:0022836;ligand-gated calcium channel activity#GO:0099604;calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873;ligand-gated monoatomic ion channel activity#GO:0015276;channel activity#GO:0015267;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;calcium channel activity#GO:0005262;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;monoatomic cation channel activity#GO:0005261 organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;lytic vacuole#GO:0000323;vacuolar membrane#GO:0005774;lysosomal membrane#GO:0005765;cell periphery#GO:0071944;membrane#GO:0016020;vacuole#GO:0005773;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;lysosome#GO:0005764;lytic vacuole membrane#GO:0098852;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 ion channel#PC00133;transporter#PC00227 HUMAN|HGNC=10790|UniProtKB=Q12872 Q12872 SFSWAP PTHR13161:SF15 SPLICING FACTOR SUPPRESSOR OF WHITE APRICOT SPLICING FACTOR, SUPPRESSOR OF WHITE-APRICOT HOMOLOG macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA splicing, via transesterification reactions#GO:0000375;protein-RNA complex assembly#GO:0022618;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;alternative mRNA splicing, via spliceosome#GO:0000380;protein-RNA complex organization#GO:0071826;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;mRNA processing#GO:0006397;RNA processing#GO:0006396;mRNA splice site recognition#GO:0006376;cellular component assembly#GO:0022607;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;spliceosomal complex assembly#GO:0000245;RNA metabolic process#GO:0016070;protein-containing complex assembly#GO:0065003;mRNA splicing, via spliceosome#GO:0000398;cellular component organization#GO:0016043;mRNA metabolic process#GO:0016071;mRNA cis splicing, via spliceosome#GO:0045292;ribonucleoprotein complex biogenesis#GO:0022613 nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 RNA processing factor#PC00147;RNA metabolism protein#PC00031;RNA splicing factor#PC00148 HUMAN|HGNC=28091|UniProtKB=Q52LC2 Q52LC2 ATP6AP1L PTHR12471:SF3 VACUOLAR ATP SYNTHASE SUBUNIT S1 V-TYPE PROTON ATPASE SUBUNIT S1-LIKE PROTEIN intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion homeostasis#GO:0050801;biological regulation#GO:0065007;homeostatic process#GO:0042592;regulation of intracellular pH#GO:0051453;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;regulation of pH#GO:0006885;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;regulation of biological quality#GO:0065008 ATPase dependent transmembrane transport complex#GO:0098533;proton-transporting V-type ATPase complex#GO:0033176;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;ATPase complex#GO:1904949;proton-transporting two-sector ATPase complex#GO:0016469;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cation-transporting ATPase complex#GO:0090533;membrane#GO:0016020;membrane protein complex#GO:0098796 primary active transporter#PC00068;ATP synthase#PC00002 HUMAN|HGNC=34433|UniProtKB=Q30KP8 Q30KP8 DEFB136 PTHR39413:SF1 BETA-DEFENSIN 136 DEFENSIN BETA 136 lipopolysaccharide binding#GO:0001530;binding#GO:0005488;carbohydrate derivative binding#GO:0097367;lipid binding#GO:0008289 biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;defense response to fungus#GO:0050832;response to stimulus#GO:0050896;defense response to bacterium#GO:0042742;immune system process#GO:0002376;response to bacterium#GO:0009617;defense response to symbiont#GO:0140546;immune response#GO:0006955;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;response to other organism#GO:0051707;defense response to other organism#GO:0098542;response to external stimulus#GO:0009605;defense response#GO:0006952;innate immune response#GO:0045087 defense/immunity protein#PC00090;antimicrobial response protein#PC00051 HUMAN|HGNC=21487|UniProtKB=Q8TC41 Q8TC41 RNF217 PTHR11685:SF479 RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING E3 UBIQUITIN-PROTEIN LIGASE RNF217 aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;protein binding#GO:0005515;ubiquitin-like protein transferase activity#GO:0019787;enzyme binding#GO:0019899;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;binding#GO:0005488 protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238;catabolic process#GO:0009056 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;ubiquitin ligase complex#GO:0000151;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;catalytic complex#GO:1902494;transferase complex#GO:1990234 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=24497|UniProtKB=Q6ZRI6 Q6ZRI6 C15orf39 PTHR28422:SF1 SIMILAR TO HUMAN CHROMOSOME 15 OPEN READING FRAME 39 SIMILAR TO HUMAN CHROMOSOME 15 OPEN READING FRAME 39 regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;regulation of response to stress#GO:0080134;regulation of canonical NF-kappaB signal transduction#GO:0043122;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;negative regulation of response to external stimulus#GO:0032102;biological regulation#GO:0065007;negative regulation of response to stimulus#GO:0048585;regulation of response to external stimulus#GO:0032101;regulation of defense response#GO:0031347;regulation of signaling#GO:0023051;regulation of inflammatory response#GO:0050727;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of cell communication#GO:0010646;negative regulation of defense response#GO:0031348;regulation of cellular process#GO:0050794;negative regulation of inflammatory response#GO:0050728;negative regulation of canonical NF-kappaB signal transduction#GO:0043124 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=4978|UniProtKB=Q14774 Q14774 HLX PTHR46808:SF1 H2.0-LIKE HOMEOBOX PROTEIN H2.0-LIKE HOMEOBOX PROTEIN sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;binding#GO:0005488;nucleic acid binding#GO:0003676 homeodomain transcription factor#PC00119 HUMAN|HGNC=25931|UniProtKB=Q0VF96 Q0VF96 CGNL1 PTHR46349:SF2 CINGULIN-LIKE PROTEIN 1-RELATED CINGULIN-LIKE PROTEIN 1 localization#GO:0051179;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;protein localization to cell junction#GO:1902414 apical junction complex#GO:0043296;cell-cell junction#GO:0005911;cell junction#GO:0030054;bicellular tight junction#GO:0005923;cellular anatomical structure#GO:0110165;tight junction#GO:0070160;anchoring junction#GO:0070161 HUMAN|HGNC=16893|UniProtKB=O60664 O60664 PLIN3 PTHR14024:SF11 PERILIPIN PERILIPIN-3 cellular process#GO:0009987;regulation of biological process#GO:0050789;positive regulation of cellular process#GO:0048522;lipid storage#GO:0019915;positive regulation of biological process#GO:0048518;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of localization#GO:0032879 intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;lipid droplet#GO:0005811;cytosol#GO:0005829;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232 scaffold/adaptor protein#PC00226 HUMAN|HGNC=18441|UniProtKB=Q8TDW4 Q8TDW4 ST7L PTHR12745:SF4 SUPPRESSION OF TUMORIGENICITY 7 SUPPRESSOR OF TUMORIGENICITY 7 PROTEIN-LIKE HUMAN|HGNC=16077|UniProtKB=Q9NRW4 Q9NRW4 DUSP22 PTHR45948:SF3 DUAL SPECIFICITY PROTEIN PHOSPHATASE DDB_G0269404-RELATED DUAL SPECIFICITY PROTEIN PHOSPHATASE 22 catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725;phosphoprotein phosphatase activity#GO:0004721 cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;positive regulation of MAPK cascade#GO:0043410;positive regulation of cellular process#GO:0048522;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;response to transforming growth factor beta#GO:0071559;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;cellular response to transforming growth factor beta stimulus#GO:0071560;response to growth factor#GO:0070848;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of cell communication#GO:0010646;regulation of MAPK cascade#GO:0043408;cell surface receptor signaling pathway#GO:0007166;regulation of JNK cascade#GO:0046328;transforming growth factor beta receptor signaling pathway#GO:0007179;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;positive regulation of JNK cascade#GO:0046330;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;cellular response to growth factor stimulus#GO:0071363;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;signaling#GO:0023052 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;protein phosphatase#PC00195 Oxidative stress response#P00046>MKP5#P01131 HUMAN|HGNC=7673|UniProtKB=Q9Y618 Q9Y618 NCOR2 PTHR13992:SF21 NUCLEAR RECEPTOR CO-REPRESSOR RELATED NCOR NUCLEAR RECEPTOR COREPRESSOR 2 transcription regulator activity#GO:0140110;transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712 negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357 chromatin#GO:0000785;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 chromatin/chromatin-binding, or -regulatory protein#PC00077 Notch signaling pathway#P00045>CoR#P01112;Huntington disease#P00029>N-CoR#P00770 HUMAN|HGNC=4450|UniProtKB=Q8N158 Q8N158 GPC2 PTHR10822:SF24 GLYPICAN GLYPICAN-2 regulation of localization#GO:0032879;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;cell migration#GO:0016477;regulation of protein localization to membrane#GO:1905475;signal transduction#GO:0007165;cellular process#GO:0009987;smoothened signaling pathway#GO:0007224;regulation of protein localization#GO:0032880;cell communication#GO:0007154;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell motility#GO:0048870;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716 synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;cell junction#GO:0030054;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576 scaffold/adaptor protein#PC00226 HUMAN|HGNC=1455|UniProtKB=P27797 P27797 CALR PTHR11073:SF16 CALRETICULIN AND CALNEXIN CALRETICULIN cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167 macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;response to stress#GO:0006950;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;protein maturation#GO:0051604;response to chemical#GO:0042221;proteasomal protein catabolic process#GO:0010498;biosynthetic process#GO:0009058;response to endoplasmic reticulum stress#GO:0034976;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;protein metabolic process#GO:0019538;ERAD pathway#GO:0036503;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;catabolic process#GO:0009056;response to stimulus#GO:0050896;protein folding#GO:0006457 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229 chaperone#PC00072 HUMAN|HGNC=23791|UniProtKB=Q27J81 Q27J81 INF2 PTHR46345:SF8 INVERTED FORMIN-2 INVERTED FORMIN-2 HUMAN|HGNC=12997|UniProtKB=Q96SZ4 Q96SZ4 ZSCAN10 PTHR24377:SF369 IP01015P-RELATED ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 10 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987 regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=29199|UniProtKB=Q9ULS5 Q9ULS5 TMCC3 PTHR17613:SF8 CEREBRAL PROTEIN-11-RELATED TRANSMEMBRANE AND COILED-COIL DOMAIN PROTEIN 3 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 HUMAN|HGNC=13700|UniProtKB=Q8N6P7 Q8N6P7 IL22RA1 PTHR20859:SF53 INTERFERON/INTERLEUKIN RECEPTOR INTERLEUKIN-22 RECEPTOR SUBUNIT ALPHA-1 signaling receptor activity#GO:0038023;immune receptor activity#GO:0140375;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;cytokine receptor activity#GO:0004896 signal transduction#GO:0007165;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to cytokine#GO:0034097;response to stimulus#GO:0050896;response to chemical#GO:0042221;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;cytokine-mediated signaling pathway#GO:0019221;cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;response to peptide#GO:1901652 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=7467|UniProtKB=P55157 P55157 MTTP PTHR13024:SF1 MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN, LARGE SUBUNIT MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN LARGE SUBUNIT primary metabolic process#GO:0044238;lipid homeostasis#GO:0055088;cellular process#GO:0009987;lipoprotein metabolic process#GO:0042157;homeostatic process#GO:0042592;metabolic process#GO:0008152;chemical homeostasis#GO:0048878;protein metabolic process#GO:0019538;cholesterol homeostasis#GO:0042632;macromolecule metabolic process#GO:0043170 basal part of cell#GO:0045178;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cell periphery#GO:0071944;basal plasma membrane#GO:0009925;membrane#GO:0016020;basolateral plasma membrane#GO:0016323;cytoplasm#GO:0005737;plasma membrane#GO:0005886;endomembrane system#GO:0012505;plasma membrane region#GO:0098590;endoplasmic reticulum#GO:0005783;Golgi apparatus#GO:0005794 transporter#PC00227 HUMAN|HGNC=19839|UniProtKB=Q96NE9 Q96NE9 FRMD6 PTHR13429:SF11 FERM DOMAIN (PROTEIN4.1-EZRIN-RADIXIN-MOESIN) FAMILY FERM DOMAIN-CONTAINING PROTEIN 6 molecular sequestering activity#GO:0140313;protein sequestering activity#GO:0140311 positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of cell communication#GO:0010646;regulation of hippo signaling#GO:0035330;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583 cell periphery#GO:0071944;membrane#GO:0016020;cell-cell junction#GO:0005911;anchoring junction#GO:0070161;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell junction#GO:0030054 HUMAN|HGNC=19147|UniProtKB=Q8N144 Q8N144 GJD3 PTHR11984:SF5 CONNEXIN GAP JUNCTION DELTA-3 PROTEIN transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;channel activity#GO:0015267;wide pore channel activity#GO:0022829 cell-cell signaling#GO:0007267;signaling#GO:0023052;biological regulation#GO:0065007;cell communication#GO:0007154;regulation of biological process#GO:0050789;cellular process#GO:0009987 cell junction#GO:0030054;anchoring junction#GO:0070161;cell-cell junction#GO:0005911;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886 cell junction protein#PC00070;gap junction#PC00105 HUMAN|HGNC=17102|UniProtKB=Q92619 Q92619 ARHGAP45 PTHR15228:SF18 SPERMATHECAL PHYSIOLOGY VARIANT RHO GTPASE-ACTIVATING PROTEIN 45 enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096 negative regulation of response to stimulus#GO:0048585;negative regulation of signal transduction#GO:0009968;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of small GTPase mediated signal transduction#GO:0051056;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051 membrane#GO:0016020;cellular anatomical structure#GO:0110165 GTPase-activating protein#PC00257;protein-binding activity modulator#PC00095;G-protein modulator#PC00022 HUMAN|HGNC=9707|UniProtKB=Q92692 Q92692 NECTIN2 PTHR47387:SF1 NECTIN-2 NECTIN-2 signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018 positive regulation of leukocyte mediated immunity#GO:0002705;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of immune effector process#GO:0002699;homophilic cell-cell adhesion#GO:0007156;cell-cell adhesion#GO:0098609;positive regulation of immune system process#GO:0002684;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of lymphocyte mediated immunity#GO:0002708;positive regulation of signaling#GO:0023056;regulation of immune effector process#GO:0002697;regulation of lymphocyte mediated immunity#GO:0002706;cell adhesion#GO:0007155;regulation of immune response#GO:0050776;regulation of signaling#GO:0023051;positive regulation of adaptive immune response#GO:0002821;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of cell communication#GO:0010646;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789;regulation of leukocyte mediated immunity#GO:0002703 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;cell-cell junction#GO:0005911;membrane#GO:0016020;anchoring junction#GO:0070161;cell junction#GO:0030054;apical junction complex#GO:0043296 HUMAN|HGNC=2766|UniProtKB=P60022 P60022 DEFB1 PTHR21388:SF9 BETA-DEFENSIN-RELATED BETA-DEFENSIN 1 G protein-coupled receptor binding#GO:0001664;signaling receptor binding#GO:0005102;binding#GO:0005488;cytokine receptor binding#GO:0005126;chemokine receptor binding#GO:0042379;protein binding#GO:0005515 innate immune response#GO:0045087;defense response#GO:0006952;response to external stimulus#GO:0009605;defense response to other organism#GO:0098542;response to other organism#GO:0051707;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;defense response to symbiont#GO:0140546;immune response#GO:0006955;response to bacterium#GO:0009617;immune system process#GO:0002376;defense response to bacterium#GO:0042742;response to stimulus#GO:0050896;defense response to Gram-negative bacterium#GO:0050829;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;defense response to Gram-positive bacterium#GO:0050830 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090;antimicrobial response protein#PC00051 HUMAN|HGNC=19357|UniProtKB=Q9H3C7 Q9H3C7 GGNBP2 PTHR13601:SF3 GAMETOGENETIN-BINDING PROTEIN 2 GAMETOGENETIN-BINDING PROTEIN 2 placenta development#GO:0001890;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;animal organ development#GO:0048513;developmental process#GO:0032502;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of signal transduction#GO:0009968;embryo development#GO:0009790;negative regulation of response to stimulus#GO:0048585;multicellular organismal process#GO:0032501;cellular process#GO:0009987;negative regulation of cell communication#GO:0010648;anatomical structure development#GO:0048856;embryonic organ development#GO:0048568;embryo development ending in birth or egg hatching#GO:0009792;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;chordate embryonic development#GO:0043009;animal gross anatomical part developmental process#GO:0160108;regulation of cell communication#GO:0010646;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HUMAN|HGNC=21705|UniProtKB=O75223 O75223 GGCT PTHR12935:SF0 GAMMA-GLUTAMYLCYCLOTRANSFERASE GAMMA-GLUTAMYLCYCLOTRANSFERASE lyase activity#GO:0016829;catalytic activity#GO:0003824 HUMAN|HGNC=8529|UniProtKB=P30559 P30559 OXTR PTHR24241:SF89 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR OXYTOCIN RECEPTOR transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 regulation of system process#GO:0044057;regulation of anatomical structure size#GO:0090066;system process#GO:0003008;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;response to hormone#GO:0009725;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;blood circulation#GO:0008015;response to chemical#GO:0042221;circulatory system process#GO:0003013;G protein-coupled receptor signaling pathway#GO:0007186;positive regulation of cytosolic calcium ion concentration#GO:0007204;cellular response to chemical stimulus#GO:0070887;regulation of biological quality#GO:0065008;cell communication#GO:0007154;positive regulation of multicellular organismal process#GO:0051240;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;signaling#GO:0023052;cellular response to hormone stimulus#GO:0032870;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 Oxytocin receptor mediated signaling pathway#P04391>Oxytocin Receptor#P04531 HUMAN|HGNC=17218|UniProtKB=Q9NSJ1 Q9NSJ1 ZNF355P PTHR24377:SF938 IP01015P-RELATED ZINC FINGER PROTEIN 429-RELATED transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=7541|UniProtKB=P84157 P84157 MXRA7 PTHR21845:SF2 TRANSMEMBRANE ANCHOR PROTEIN 1 MATRIX-REMODELING-ASSOCIATED PROTEIN 7 HUMAN|HGNC=20797|UniProtKB=Q53TN4 Q53TN4 CYBRD1 PTHR10106:SF12 CYTOCHROME B561-RELATED PLASMA MEMBRANE ASCORBATE-DEPENDENT REDUCTASE CYBRD1 oxidoreductase activity#GO:0016491;primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804;oxidoreductase activity, acting on metal ions#GO:0016722;catalytic activity#GO:0003824;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 monoatomic ion homeostasis#GO:0050801;intracellular monoatomic ion homeostasis#GO:0006873;carbohydrate homeostasis#GO:0033500;intracellular iron ion homeostasis#GO:0006879;homeostatic process#GO:0042592;chemical homeostasis#GO:0048878;inorganic ion homeostasis#GO:0098771;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082 brush border#GO:0005903;cell periphery#GO:0071944;apical plasma membrane#GO:0016324;membrane#GO:0016020;plasma membrane#GO:0005886;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;plasma membrane region#GO:0098590;brush border membrane#GO:0031526;cellular anatomical structure#GO:0110165;apical part of cell#GO:0045177;cluster of actin-based cell projections#GO:0098862;cell projection membrane#GO:0031253 oxidoreductase#PC00176;reductase#PC00198 HUMAN|HGNC=31814|UniProtKB=Q6UY18 Q6UY18 LINGO4 PTHR24373:SF156 SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN LEUCINE-RICH REPEAT AND IMMUNOGLOBULIN-LIKE DOMAIN-CONTAINING NOGO RECEPTOR-INTERACTING PROTEIN 4 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=7549|UniProtKB=Q00872 Q00872 MYBPC1 PTHR13817:SF27 TITIN MYOSIN-BINDING PROTEIN C, SLOW-TYPE structural molecule activity#GO:0005198 supramolecular fiber organization#GO:0097435;striated muscle cell development#GO:0055002;anatomical structure development#GO:0048856;sarcomere organization#GO:0045214;actin filament-based process#GO:0030029;organelle assembly#GO:0070925;animal gross anatomical part developmental process#GO:0160108;cellular component assembly involved in morphogenesis#GO:0010927;actomyosin structure organization#GO:0031032;cell development#GO:0048468;cell differentiation#GO:0030154;actin cytoskeleton organization#GO:0030036;muscle structure development#GO:0061061;myofibril assembly#GO:0030239;muscle cell differentiation#GO:0042692;anatomical structure morphogenesis#GO:0009653;muscle cell development#GO:0055001;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;striated muscle cell differentiation#GO:0051146;anatomical structure formation involved in morphogenesis#GO:0048646;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;developmental process#GO:0032502;cellular anatomical entity morphogenesis#GO:0032989;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996 A band#GO:0031672;contractile muscle fiber#GO:0043292;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;organelle#GO:0043226;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;M band#GO:0031430;intracellular organelle#GO:0043229;myofibril#GO:0030016;membraneless organelle#GO:0043228;sarcomere#GO:0030017;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512 structural protein#PC00211 HUMAN|HGNC=12208|UniProtKB=A0A0K0K1C4 A0A0K0K1C4 TRBV27 PTHR23268:SF28 T-CELL RECEPTOR BETA CHAIN T CELL RECEPTOR BETA VARIABLE 27 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=21597|UniProtKB=Q6JQN1 Q6JQN1 ACAD10 PTHR48083:SF35 MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED ACYL-COA DEHYDROGENASE FAMILY MEMBER 10 catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;oxidoreductase activity#GO:0016491 carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;monocarboxylic acid metabolic process#GO:0032787;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;small molecule catabolic process#GO:0044282;oxoacid metabolic process#GO:0043436;lipid oxidation#GO:0034440;fatty acid catabolic process#GO:0009062;cellular process#GO:0009987;lipid catabolic process#GO:0016042;carboxylic acid catabolic process#GO:0046395;monocarboxylic acid catabolic process#GO:0072329;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;fatty acid beta-oxidation#GO:0006635;fatty acid oxidation#GO:0019395;lipid modification#GO:0030258 mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 dehydrogenase#PC00092 5-Hydroxytryptamine degredation#P04372>Aldehyde Dehydrogenase#P04402 HUMAN|HGNC=33787|UniProtKB=Q5JPI9 Q5JPI9 EEF1AKMT2 PTHR12843:SF5 PROTEIN-LYSINE N-METHYLTRANSFERASE METTL10 EEF1A LYSINE METHYLTRANSFERASE 2 protein methyltransferase activity#GO:0008276;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a protein#GO:0140096;protein-lysine N-methyltransferase activity#GO:0016279;N-methyltransferase activity#GO:0008170;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;lysine N-methyltransferase activity#GO:0016278 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260 HUMAN|HGNC=34448|UniProtKB=A6NFE2 A6NFE2 SMCO2 PTHR22422:SF5 TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 5B-RELATED SINGLE-PASS MEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 2 HUMAN|HGNC=31652|UniProtKB=Q9UD57 Q9UD57 NKX1-2 PTHR24340:SF17 HOMEOBOX PROTEIN NKX NK1 TRANSCRIPTION FACTOR-RELATED PROTEIN 2 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 cellular process#GO:0009987;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;developmental process#GO:0032502;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=11865|UniProtKB=Q99805 Q99805 TM9SF2 PTHR10766:SF55 TRANSMEMBRANE 9 SUPERFAMILY PROTEIN TRANSMEMBRANE 9 SUPERFAMILY MEMBER 2 macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657;localization within membrane#GO:0051668;cellular process#GO:0009987;localization#GO:0051179;cellular localization#GO:0051641;intracellular protein localization#GO:0008104 cellular anatomical structure#GO:0110165;membrane#GO:0016020 transporter#PC00227 HUMAN|HGNC=12151|UniProtKB=A0A0B4J262 A0A0B4J262 TRAV8-6 PTHR19367:SF11 T-CELL RECEPTOR ALPHA CHAIN V REGION T CELL RECEPTOR ALPHA VARIABLE 8-6 response to stimulus#GO:0050896;adaptive immune response#GO:0002250;immune system process#GO:0002376;immune response#GO:0006955 protein-containing complex#GO:0032991 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=23605|UniProtKB=Q6L8G5 Q6L8G5 KRTAP5-10 PTHR23262:SF218 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 5-10-RELATED structural protein#PC00211 HUMAN|HGNC=14451|UniProtKB=Q9BQK8 Q9BQK8 LPIN3 PTHR12181:SF62 LIPIN PHOSPHATIDATE PHOSPHATASE LPIN3 transcription coactivator activity#GO:0003713;phosphoric ester hydrolase activity#GO:0042578;transcription coregulator activity#GO:0003712;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;transcription regulator activity#GO:0140110 regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;response to nitrogen compound#GO:1901698;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;cellular response to peptide hormone stimulus#GO:0071375;positive regulation of RNA metabolic process#GO:0051254;primary metabolic process#GO:0044238;response to insulin#GO:0032868;cellular response to stimulus#GO:0051716;regulation of biosynthetic process#GO:0009889;neutral lipid metabolic process#GO:0006638;regulation of gene expression#GO:0010468;acylglycerol metabolic process#GO:0006639;fatty acid metabolic process#GO:0006631;cellular response to insulin stimulus#GO:0032869;triglyceride metabolic process#GO:0006641;lipid metabolic process#GO:0006629;monocarboxylic acid catabolic process#GO:0072329;positive regulation of DNA-templated transcription#GO:0045893;lipid biosynthetic process#GO:0008610;cellular response to nitrogen compound#GO:1901699;triglyceride biosynthetic process#GO:0019432;regulation of nucleobase-containing compound metabolic process#GO:0019219;response to peptide hormone#GO:0043434;biosynthetic process#GO:0009058;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;glycerolipid biosynthetic process#GO:0045017;carboxylic acid catabolic process#GO:0046395;positive regulation of cellular process#GO:0048522;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;fatty acid catabolic process#GO:0009062;oxoacid metabolic process#GO:0043436;cellular response to chemical stimulus#GO:0070887;response to oxygen-containing compound#GO:1901700;cellular response to hormone stimulus#GO:0032870;glycerolipid metabolic process#GO:0046486;small molecule metabolic process#GO:0044281;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;small molecule catabolic process#GO:0044282;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;metabolic process#GO:0008152;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of macromolecule metabolic process#GO:0010604;response to chemical#GO:0042221;response to hormone#GO:0009725;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;lipid catabolic process#GO:0016042;positive regulation of biological process#GO:0048518 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 hydrolase#PC00121;phosphatase#PC00181 HUMAN|HGNC=6021|UniProtKB=P40189 P40189 IL6ST PTHR23036:SF83 CYTOKINE RECEPTOR INTERLEUKIN-6 RECEPTOR SUBUNIT BETA cytokine receptor activity#GO:0004896;immune receptor activity#GO:0140375;signaling receptor activity#GO:0038023;cytokine binding#GO:0019955;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;protein binding#GO:0005515 cell surface receptor signaling pathway#GO:0007166;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;response to cytokine#GO:0034097;response to chemical#GO:0042221;biological regulation#GO:0065007;cytokine-mediated signaling pathway#GO:0019221;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;response to peptide#GO:1901652;positive regulation of cell population proliferation#GO:0008284;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;signaling receptor complex#GO:0043235;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 Interleukin signaling pathway#P00036>Signaling subunit#P00969 HUMAN|HGNC=40024|UniProtKB=E9PGG2 E9PGG2 ANHX PTHR10390:SF34 HOMEOBOX PROTEIN SIX ANOMALOUS HOMEOBOX PROTEIN sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119 HUMAN|HGNC=20997|UniProtKB=Q9H091 Q9H091 ZMYND15 PTHR47085:SF1 ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 15 ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 15 enzyme binding#GO:0019899;binding#GO:0005488;protein binding#GO:0005515;histone deacetylase binding#GO:0042826 cell development#GO:0048468;cellular process involved in reproduction in multicellular organism#GO:0022412;negative regulation of metabolic process#GO:0009892;gamete generation#GO:0007276;cell differentiation#GO:0030154;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;spermatid differentiation#GO:0048515;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;reproductive process#GO:0022414;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;germ cell development#GO:0007281;developmental process involved in reproduction#GO:0003006;multicellular organismal reproductive process#GO:0048609;regulation of RNA metabolic process#GO:0051252;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;spermatid development#GO:0007286;sexual reproduction#GO:0019953;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;male gamete generation#GO:0048232;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;spermatogenesis#GO:0007283;negative regulation of cellular process#GO:0048523 HUMAN|HGNC=1585|UniProtKB=P30281 P30281 CCND3 PTHR10177:SF65 CYCLINS G1_S-SPECIFIC CYCLIN-D3 enzyme regulator activity#GO:0030234;cyclin-dependent protein kinase regulator activity#GO:0019914;protein kinase regulator activity#GO:0019887;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538 regulation of cell cycle#GO:0051726;regulation of cell cycle G1/S phase transition#GO:1902806;mitotic cell cycle#GO:0000278;regulation of cellular process#GO:0050794;cell cycle phase transition#GO:0044770;positive regulation of cell cycle process#GO:0090068;regulation of biological process#GO:0050789;cell cycle process#GO:0022402;cell cycle#GO:0007049;regulation of cell cycle phase transition#GO:1901987;regulation of mitotic cell cycle phase transition#GO:1901990;regulation of G1/S transition of mitotic cell cycle#GO:2000045;mitotic cell cycle phase transition#GO:0044772;regulation of cell cycle process#GO:0010564;biological regulation#GO:0065007;positive regulation of cell cycle#GO:0045787;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cell cycle G1/S phase transition#GO:0044843;cellular process#GO:0009987;regulation of mitotic cell cycle#GO:0007346;mitotic cell cycle process#GO:1903047;positive regulation of mitotic cell cycle#GO:0045931;positive regulation of cell cycle G1/S phase transition#GO:1902808;G1/S transition of mitotic cell cycle#GO:0000082 membraneless organelle#GO:0043228;protein kinase complex#GO:1902911;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;transferase complex#GO:1990234;protein-containing complex#GO:0032991;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 kinase activator#PC00138 Cell cycle#P00013>Cyclin D#P00484 HUMAN|HGNC=7015|UniProtKB=Q16819 Q16819 MEP1A PTHR10127:SF824 DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING MEPRIN A SUBUNIT ALPHA metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467;cellular process#GO:0009987;protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;signaling receptor ligand precursor processing#GO:0140448;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;proteolysis#GO:0006508;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 metalloprotease#PC00153;protease#PC00190 HUMAN|HGNC=4271|UniProtKB=P48546 P48546 GIPR PTHR45620:SF5 PDF RECEPTOR-LIKE PROTEIN-RELATED GASTRIC INHIBITORY POLYPEPTIDE RECEPTOR signaling receptor activity#GO:0038023;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528 G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=19576|UniProtKB=A3KFT3 A3KFT3 OR2M5 PTHR26453:SF28 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2M5 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;sensory perception#GO:0007600;nervous system process#GO:0050877;system process#GO:0003008;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;detection of chemical stimulus#GO:0009593;response to chemical#GO:0042221;response to stimulus#GO:0050896;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=1245|UniProtKB=P02747 P02747 C1QC PTHR15427:SF29 EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER COMPLEMENT C1Q SUBCOMPONENT SUBUNIT C molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;regulation of immune response#GO:0050776;immune system process#GO:0002376;regulation of immune system process#GO:0002682;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;immune effector process#GO:0002252;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;humoral immune response#GO:0006959;adaptive immune response#GO:0002250;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;immune response#GO:0006955;positive regulation of biological process#GO:0048518;complement activation#GO:0006956;activation of immune response#GO:0002253;positive regulation of immune system process#GO:0002684 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165;synapse#GO:0045202;extrinsic component of plasma membrane#GO:0019897;extrinsic component of membrane#GO:0019898;cell junction#GO:0030054;synaptic membrane#GO:0097060;extracellular protein-containing complex#GO:0140392;glutamatergic synapse#GO:0098978;protein-containing complex#GO:0032991;plasma membrane region#GO:0098590;presynaptic membrane#GO:0042734;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;presynapse#GO:0098793 scaffold/adaptor protein#PC00226 HUMAN|HGNC=16031|UniProtKB=Q96EP0 Q96EP0 RNF31 PTHR16004:SF5 RING FINGER PROTEIN 31-RELATED E3 UBIQUITIN-PROTEIN LIGASE RNF31 modification-dependent protein binding#GO:0140030;binding#GO:0005488;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;protein binding#GO:0005515;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;transferase activity#GO:0016740;K63-linked polyubiquitin modification-dependent protein binding#GO:0070530;polyubiquitin modification-dependent protein binding#GO:0031593;catalytic activity#GO:0003824;ubiquitin binding#GO:0043130;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;cellular process#GO:0009987;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=2745|UniProtKB=O00571 O00571 DDX3X PTHR47958:SF175 ATP-DEPENDENT RNA HELICASE DBP3 ATP-DEPENDENT RNA HELICASE DDX3X macromolecular conformation isomerase activity#GO:0120543;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;RNA helicase activity#GO:0003724;catalytic activity#GO:0003824;catalytic activity, acting on RNA#GO:0140098;isomerase activity#GO:0016853;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;sexual reproduction#GO:0019953;multicellular organismal reproductive process#GO:0048609;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;gamete generation#GO:0007276;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;reproductive process#GO:0022414 cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;ribonucleoprotein granule#GO:0035770;organelle#GO:0043226;supramolecular complex#GO:0099080;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;nucleus#GO:0005634;membraneless organelle#GO:0043228;P granule#GO:0043186;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 RNA helicase#PC00032 HUMAN|HGNC=23665|UniProtKB=Q5TYW2 Q5TYW2 ANKRD20A1 PTHR24147:SF1 ANKYRIN REPEAT DOMAIN 36-RELATED ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 20A1-RELATED HUMAN|HGNC=35410|UniProtKB=Q8NFU3 Q8NFU3 TSTD1 PTHR45544:SF1 THIOSULFATE:GLUTATHIONE SULFURTRANSFERASE THIOSULFATE:GLUTATHIONE SULFURTRANSFERASE metabolite interconversion enzyme#PC00262;transferase#PC00220 HUMAN|HGNC=28445|UniProtKB=Q8NB15 Q8NB15 ZNF511 PTHR21354:SF0 ZINC FINGER PROTEIN 511 ZINC FINGER PROTEIN 511 HUMAN|HGNC=9689|UniProtKB=Q03393 Q03393 PTS PTHR12589:SF10 PYRUVOYL TETRAHYDROBIOPTERIN SYNTHASE 6-PYRUVOYL TETRAHYDROBIOPTERIN SYNTHASE lyase activity#GO:0016829;carbon-oxygen lyase activity#GO:0016835;catalytic activity#GO:0003824 biosynthetic process#GO:0009058;pteridine-containing compound metabolic process#GO:0042558;small molecule metabolic process#GO:0044281;cellular process#GO:0009987;alcohol biosynthetic process#GO:0046165;small molecule biosynthetic process#GO:0044283;alcohol metabolic process#GO:0006066;metabolic process#GO:0008152 mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=15830|UniProtKB=Q8N2R0 Q8N2R0 OSR2 PTHR14196:SF4 ODD-SKIPPED - RELATED PROTEIN ODD-SKIPPED-RELATED 2 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677 regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;negative regulation of transcription by RNA polymerase II#GO:0000122;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;pattern specification process#GO:0007389;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;animal gross anatomical part developmental process#GO:0160108;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;animal organ development#GO:0048513;multicellular organism development#GO:0007275;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;renal system development#GO:0072001;negative regulation of macromolecule biosynthetic process#GO:0010558;kidney development#GO:0001822 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 zinc finger transcription factor#PC00244;DNA-binding transcription factor#PC00218 HUMAN|HGNC=29072|UniProtKB=A2RUR9 A2RUR9 CCDC144A PTHR22245:SF3 COILED-COIL DOMAIN-CONTAINING PROTEIN 144A-RELATED COILED-COIL DOMAIN-CONTAINING PROTEIN 144A-RELATED HUMAN|HGNC=1353|UniProtKB=P07358 P07358 C8B PTHR45742:SF5 COMPLEMENT COMPONENT C6 COMPLEMENT COMPONENT C8 BETA CHAIN immune system process#GO:0002376;regulation of immune response#GO:0050776;regulation of immune system process#GO:0002682;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;humoral immune response#GO:0006959;regulation of response to stimulus#GO:0048583;immune effector process#GO:0002252;positive regulation of immune response#GO:0050778;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;positive regulation of immune system process#GO:0002684;complement activation#GO:0006956;activation of immune response#GO:0002253;immune response#GO:0006955;positive regulation of biological process#GO:0048518 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane#GO:0016020;membrane protein complex#GO:0098796;extracellular region#GO:0005576 complement component#PC00078 HUMAN|HGNC=23603|UniProtKB=O75690 O75690 KRTAP5-8 PTHR23262:SF212 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 5-8 structural protein#PC00211 HUMAN|HGNC=13932|UniProtKB=Q5SRR4 Q5SRR4 LY6G5C PTHR14909:SF6 LYMPHOCYTE ANTIGEN 6 COMPLEX LOCUS PROTEIN G5C LYMPHOCYTE ANTIGEN 6 COMPLEX LOCUS PROTEIN G5C plasma membrane#GO:0005886;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020 HUMAN|HGNC=3331|UniProtKB=P50402 P50402 EMD PTHR15171:SF2 EMERIN EMERIN tubulin binding#GO:0015631;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;protein binding#GO:0005515 regulation of canonical Wnt signaling pathway#GO:0060828;negative regulation of Wnt signaling pathway#GO:0030178;negative regulation of response to stimulus#GO:0048585;negative regulation of signal transduction#GO:0009968;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111;negative regulation of signaling#GO:0023057;negative regulation of canonical Wnt signaling pathway#GO:0090090;regulation of signaling#GO:0023051;negative regulation of cell communication#GO:0010648 membrane#GO:0016020;microtubule cytoskeleton#GO:0015630;nucleus#GO:0005634;organelle inner membrane#GO:0019866;endomembrane system#GO:0012505;intracellular membraneless organelle#GO:0043232;nuclear envelope#GO:0005635;cytoskeleton#GO:0005856;spindle#GO:0005819;membraneless organelle#GO:0043228;organelle membrane#GO:0031090;nuclear inner membrane#GO:0005637;nuclear membrane#GO:0031965;organelle envelope#GO:0031967;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=854|UniProtKB=P21281 P21281 ATP6V1B2 PTHR43389:SF5 V-TYPE PROTON ATPASE SUBUNIT B V-TYPE PROTON ATPASE SUBUNIT B, BRAIN ISOFORM intracellular monoatomic ion homeostasis#GO:0006873;homeostatic process#GO:0042592;regulation of intracellular pH#GO:0051453;regulation of pH#GO:0006885;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;biological regulation#GO:0065007;intracellular monoatomic cation homeostasis#GO:0030003;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;establishment of localization#GO:0051234;vacuolar acidification#GO:0007035;proton transmembrane transport#GO:1902600 organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;proton-transporting V-type ATPase complex#GO:0033176;transporter complex#GO:1990351;vacuolar membrane#GO:0005774;proton-transporting two-sector ATPase complex#GO:0016469;apical part of cell#GO:0045177;cytoplasm#GO:0005737;plasma membrane#GO:0005886;vacuole#GO:0005773;protein-containing complex#GO:0032991;plasma membrane region#GO:0098590;cell periphery#GO:0071944;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;ATPase dependent transmembrane transport complex#GO:0098533;membrane-bounded organelle#GO:0043227;transmembrane transporter complex#GO:1902495;ATPase complex#GO:1904949;vacuolar proton-transporting V-type ATPase complex#GO:0016471;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;vacuolar proton-transporting V-type ATPase, V1 domain#GO:0000221;organelle#GO:0043226;cation-transporting ATPase complex#GO:0090533;apical plasma membrane#GO:0016324;membrane protein complex#GO:0098796 ATP synthase#PC00002;primary active transporter#PC00068 HUMAN|HGNC=26910|UniProtKB=Q8N2I2 Q8N2I2 ZNF619 PTHR24381:SF138 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 619 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=26114|UniProtKB=Q96F86 Q96F86 EDC3 PTHR13612:SF0 ENHANCER OF MRNA-DECAPPING PROTEIN 3 ENHANCER OF MRNA-DECAPPING PROTEIN 3 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;molecular condensate scaffold activity#GO:0140693 organelle assembly#GO:0070925;RNA decapping#GO:0110154;P-body assembly#GO:0033962;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;nucleic acid catabolic process#GO:0141188;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;nucleobase-containing compound catabolic process#GO:0034655;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;RNA catabolic process#GO:0006401;RNA metabolic process#GO:0016070;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;mRNA catabolic process#GO:0006402;organelle organization#GO:0006996;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;cellular component assembly#GO:0022607 cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;organelle#GO:0043226;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;P-body#GO:0000932 HUMAN|HGNC=19238|UniProtKB=Q9NYT0 Q9NYT0 PLEK2 PTHR12092:SF2 PLECKSTRIN PLECKSTRIN-2 actin filament-based process#GO:0030029;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;cellular component organization or biogenesis#GO:0071840 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 cytoskeletal protein#PC00085 HUMAN|HGNC=29416|UniProtKB=Q5T7W0 Q5T7W0 ZNF618 PTHR24383:SF12 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 618 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=42|UniProtKB=O95342 O95342 ABCB11 PTHR24221:SF165 ATP-BINDING CASSETTE SUB-FAMILY B BILE SALT EXPORT PUMP ATP-dependent activity#GO:0140657;transmembrane transporter activity#GO:0022857;ATPase-coupled transmembrane transporter activity#GO:0042626;transporter activity#GO:0005215;primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;cellular process#GO:0009987;transport#GO:0006810 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;cell periphery#GO:0071944;apical part of cell#GO:0045177;membrane#GO:0016020;apical plasma membrane#GO:0016324 ATP-binding cassette (ABC) transporter#PC00003 HUMAN|HGNC=18547|UniProtKB=Q9NRR3 Q9NRR3 CDC42SE2 PTHR13502:SF4 CDC42 SMALL EFFECTOR PROTEIN HOMOLOG CDC42 SMALL EFFECTOR PROTEIN 2 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HUMAN|HGNC=11429|UniProtKB=O75558 O75558 STX11 PTHR19957:SF30 SYNTAXIN SYNTAXIN-11 SNAP receptor activity#GO:0005484;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 secretion by cell#GO:0032940;protein transport#GO:0015031;localization#GO:0051179;cellular localization#GO:0051641;secretion#GO:0046903;cellular component organization#GO:0016043;export from cell#GO:0140352;vesicle fusion#GO:0006906;intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907;exocytosis#GO:0006887;intracellular protein localization#GO:0008104;vesicle organization#GO:0016050;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle organization#GO:0006996;membrane fusion#GO:0061025;macromolecule localization#GO:0033036;membrane organization#GO:0061024;organelle membrane fusion#GO:0090174;organelle fusion#GO:0048284;vesicle-mediated transport#GO:0016192 intracellular anatomical structure#GO:0005622;cell periphery#GO:0071944;membrane#GO:0016020;membrane protein complex#GO:0098796;cytoplasm#GO:0005737;plasma membrane#GO:0005886;SNARE complex#GO:0031201;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 SNARE protein#PC00034 Nicotinic acetylcholine receptor signaling pathway#P00044>SNARE Complex#P01091;Ionotropic glutamate receptor pathway#P00037>SNARE Complex#P01013;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>SNARE Complex#P01079 HUMAN|HGNC=18640|UniProtKB=Q5SW96 Q5SW96 LDLRAP1 PTHR11232:SF35 PHOSPHOTYROSINE INTERACTION DOMAIN-CONTAINING FAMILY MEMBER LOW DENSITY LIPOPROTEIN RECEPTOR ADAPTER PROTEIN 1 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;signaling adaptor activity#GO:0035591 transport#GO:0006810;receptor-mediated endocytosis#GO:0006898;plasma lipoprotein particle clearance#GO:0034381;establishment of localization#GO:0051234;import into cell#GO:0098657;localization#GO:0051179;cellular process#GO:0009987;regulation of biological process#GO:0050789;receptor internalization#GO:0031623;biological regulation#GO:0065007;endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;multicellular organismal process#GO:0032501 vesicle#GO:0031982;intracellular vesicle#GO:0097708;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endosome#GO:0005768;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410 scaffold/adaptor protein#PC00226 HUMAN|HGNC=17448|UniProtKB=Q9H4D0 Q9H4D0 CLSTN2 PTHR14139:SF3 CALSYNTENIN CALSYNTENIN-2 cell adhesion molecule binding#GO:0050839;cell adhesion mediator activity#GO:0098631;binding#GO:0005488;cell-cell adhesion mediator activity#GO:0098632;protein binding#GO:0005515 regulation of developmental process#GO:0050793;regulation of cellular component biogenesis#GO:0044087;regulation of cellular component organization#GO:0051128;positive regulation of nervous system development#GO:0051962;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;positive regulation of multicellular organismal process#GO:0051240;regulation of multicellular organismal development#GO:2000026;regulation of biological quality#GO:0065008;regulation of nervous system development#GO:0051960;regulation of synapse structure or activity#GO:0050803;cell adhesion#GO:0007155;positive regulation of cellular component organization#GO:0051130;regulation of synapse organization#GO:0050807;regulation of cell junction assembly#GO:1901888;biological regulation#GO:0065007;regulation of multicellular organismal process#GO:0051239;regulation of synapse assembly#GO:0051963;positive regulation of cellular component biogenesis#GO:0044089;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;homophilic cell-cell adhesion#GO:0007156;cell-cell adhesion#GO:0098609;positive regulation of synapse assembly#GO:0051965;positive regulation of developmental process#GO:0051094 cell junction#GO:0030054;synaptic membrane#GO:0097060;plasma membrane#GO:0005886;plasma membrane region#GO:0098590;cell surface#GO:0009986;postsynaptic specialization#GO:0099572;neuron to neuron synapse#GO:0098984;cell periphery#GO:0071944;membrane#GO:0016020;postsynaptic density membrane#GO:0098839;postsynaptic density#GO:0014069;postsynaptic specialization membrane#GO:0099634;postsynaptic membrane#GO:0045211;organelle#GO:0043226;asymmetric synapse#GO:0032279;cellular anatomical structure#GO:0110165;synapse#GO:0045202;postsynapse#GO:0098794 membrane traffic protein#PC00150 HUMAN|HGNC=25155|UniProtKB=Q86XE5 Q86XE5 HOGA1 PTHR12128:SF74 DIHYDRODIPICOLINATE SYNTHASE 4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL lyase activity#GO:0016829;carbon-carbon lyase activity#GO:0016830;catalytic activity#GO:0003824 metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;aldehyde metabolic process#GO:0006081;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;glyoxylate metabolic process#GO:0046487;monocarboxylic acid catabolic process#GO:0072329;small molecule catabolic process#GO:0044282;aldehyde catabolic process#GO:0046185 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 lyase#PC00144 HUMAN|HGNC=30171|UniProtKB=Q9UJY1 Q9UJY1 HSPB8 PTHR46906:SF1 HEAT SHOCK PROTEIN BETA-8 HEAT SHOCK PROTEIN BETA-8 response to stress#GO:0006950;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;response to topologically incorrect protein#GO:0035966;cellular response to unfolded protein#GO:0034620;cellular response to stress#GO:0033554;cellular response to topologically incorrect protein#GO:0035967;response to unfolded protein#GO:0006986 organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;intracellular organelle#GO:0043229;protein folding chaperone complex#GO:0101031 HUMAN|HGNC=26639|UniProtKB=Q8NBI6 Q8NBI6 XXYLT1 PTHR46612:SF1 XYLOSIDE XYLOSYLTRANSFERASE 1 XYLOSIDE XYLOSYLTRANSFERASE 1 UDP-xylosyltransferase activity#GO:0035252;pentosyltransferase activity#GO:0016763;catalytic activity#GO:0003824;transferase activity#GO:0016740;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;xylosyltransferase activity#GO:0042285 biosynthetic process#GO:0009058;macromolecule biosynthetic process#GO:0009059;protein O-linked glycosylation#GO:0006493;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152 membrane#GO:0016020;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum membrane#GO:0005789;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622 transferase#PC00220 HUMAN|HGNC=8109|UniProtKB=P11926 P11926 ODC1 PTHR11482:SF42 ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE ORNITHINE DECARBOXYLASE carbon-carbon lyase activity#GO:0016830;carboxy-lyase activity#GO:0016831;catalytic activity#GO:0003824;ornithine decarboxylase activity#GO:0004586;lyase activity#GO:0016829 cellular process#GO:0009987;polyamine metabolic process#GO:0006595;amine metabolic process#GO:0009308;metabolic process#GO:0008152;biosynthetic process#GO:0009058;biogenic amine metabolic process#GO:0006576;polyamine biosynthetic process#GO:0006596 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 metabolite interconversion enzyme#PC00262;decarboxylase#PC00089 CCKR signaling map#P06959>ODC1#G06989;CCKR signaling map#P06959>ODC1#P07221;Ornithine degradation#P02758>Ornithine decarboxylase#P03053 HUMAN|HGNC=15708|UniProtKB=Q8TEZ7 Q8TEZ7 PAQR8 PTHR20855:SF22 ADIPOR/PROGESTIN RECEPTOR-RELATED MEMBRANE PROGESTIN RECEPTOR BETA DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;lipid binding#GO:0008289;molecular transducer activity#GO:0060089;nuclear receptor activity#GO:0004879;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;steroid binding#GO:0005496;signaling receptor activity#GO:0038023 response to hormone#GO:0009725;response to steroid hormone#GO:0048545;response to endogenous stimulus#GO:0009719;response to lipid#GO:0033993;response to chemical#GO:0042221;response to stimulus#GO:0050896 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=10570|UniProtKB=P48594 P48594 SERPINB4 PTHR11461:SF186 SERINE PROTEASE INHIBITOR, SERPIN SERPIN B4 endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772;enzyme inhibitor activity#GO:0004857;enzyme regulator activity#GO:0030234;serine-type endopeptidase inhibitor activity#GO:0004867;molecular function inhibitor activity#GO:0140678;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414;peptidase regulator activity#GO:0061134 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HUMAN|HGNC=3424|UniProtKB=O75616 O75616 ERAL1 PTHR42698:SF1 GTPASE ERA GTPASE ERA, MITOCHONDRIAL organelle assembly#GO:0070925;ribosome assembly#GO:0042255;ribosome biogenesis#GO:0042254;protein-RNA complex assembly#GO:0022618;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;protein-containing complex assembly#GO:0065003;ribonucleoprotein complex biogenesis#GO:0022613;ribosomal small subunit biogenesis#GO:0042274;cellular component organization or biogenesis#GO:0071840;ribosomal small subunit assembly#GO:0000028;protein-RNA complex organization#GO:0071826;protein-containing complex organization#GO:0043933;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cellular component assembly#GO:0022607 intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031 HUMAN|HGNC=12148|UniProtKB=A0A0A6YYJ7 A0A0A6YYJ7 TRAV8-3 PTHR19367:SF5 T-CELL RECEPTOR ALPHA CHAIN V REGION T CELL RECEPTOR ALPHA VARIABLE 8-3 immune system process#GO:0002376;immune response#GO:0006955;response to stimulus#GO:0050896;adaptive immune response#GO:0002250 protein-containing complex#GO:0032991 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=26463|UniProtKB=Q96N06 Q96N06 SPATA33 PTHR38649:SF1 SPERMATOGENESIS-ASSOCIATED PROTEIN 33 SPERMATOGENESIS-ASSOCIATED PROTEIN 33 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=7608|UniProtKB=B2RTY4 B2RTY4 MYO9A PTHR46184:SF3 UNCONVENTIONAL MYOSIN-IXB-LIKE PROTEIN UNCONVENTIONAL MYOSIN-IXA macromolecular conformation isomerase activity#GO:0120543;cytoskeletal protein binding#GO:0008092;catalytic activity#GO:0003824;microfilament motor activity#GO:0000146;isomerase activity#GO:0016853;cytoskeletal motor activity#GO:0003774;actin binding#GO:0003779;ATP-dependent activity#GO:0140657;actin filament binding#GO:0051015;binding#GO:0005488;polypeptide conformation or assembly isomerase activity#GO:0120544;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 developmental process#GO:0032502;cellular developmental process#GO:0048869;morphogenesis of an epithelium#GO:0002009;cellular process#GO:0009987;epithelium development#GO:0060429;epithelial cell differentiation#GO:0030855;tissue development#GO:0009888;establishment or maintenance of cell polarity#GO:0007163;establishment or maintenance of apical/basal cell polarity#GO:0035088;animal gross anatomical part developmental process#GO:0160108;establishment or maintenance of bipolar cell polarity#GO:0061245;establishment or maintenance of epithelial cell apical/basal polarity#GO:0045197;tissue morphogenesis#GO:0048729;anatomical structure development#GO:0048856;anatomical structure morphogenesis#GO:0009653;establishment of cell polarity#GO:0030010;cell differentiation#GO:0030154 actin cytoskeleton#GO:0015629;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;distal axon#GO:0150034;axon#GO:0030424;intracellular organelle#GO:0043229;axonal growth cone#GO:0044295;growth cone#GO:0030426;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;site of polarized growth#GO:0030427;neuron projection#GO:0043005;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;actin filament#GO:0005884;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HUMAN|HGNC=21969|UniProtKB=P0C7M8 P0C7M8 CLEC2L PTHR47498:SF1 C-TYPE LECTIN DOMAIN FAMILY 2 MEMBER L C-TYPE LECTIN DOMAIN FAMILY 2 MEMBER L HUMAN|HGNC=6857|UniProtKB=Q99683 Q99683 MAP3K5 PTHR11584:SF332 SERINE/THREONINE PROTEIN KINASE MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5 protein serine/threonine kinase activity#GO:0004674;MAP kinase kinase kinase activity#GO:0004709;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 response to stress#GO:0006950;cellular process#GO:0009987;signal transduction#GO:0007165;JNK cascade#GO:0007254;p38MAPK cascade#GO:0038066;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;apoptotic signaling pathway#GO:0097190;programmed cell death#GO:0012501;cell death#GO:0008219;cellular response to stimulus#GO:0051716;apoptotic process#GO:0006915;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress#GO:0070059;response to stimulus#GO:0050896;signaling#GO:0023052;response to endoplasmic reticulum stress#GO:0034976;cellular response to stress#GO:0033554;intrinsic apoptotic signaling pathway#GO:0097193;neuron apoptotic process#GO:0051402;cell communication#GO:0007154;MAPK cascade#GO:0000165;intracellular signal transduction#GO:0035556 non-receptor serine/threonine protein kinase#PC00167 p38 MAPK pathway#P05918>ASK1#P06043;Integrin signalling pathway#P00034>ERK#P00907;EGF receptor signaling pathway#P00018>MEKK1-5#P00553;Apoptosis signaling pathway#P00006>ASK1#P00272;FGF signaling pathway#P00021>MEKK1-5#P00634;FAS signaling pathway#P00020>ASK1#P00614;Gonadotropin-releasing hormone receptor pathway#P06664>MAP3Ks#P06834 HUMAN|HGNC=30722|UniProtKB=Q9BY14 Q9BY14 TEX101 PTHR16529:SF3 CD177 ANTIGEN TESTIS-EXPRESSED PROTEIN 101 sperm-egg recognition#GO:0035036;cell-cell recognition#GO:0009988;single fertilization#GO:0007338;cellular process#GO:0009987;regulation of reproductive process#GO:2000241;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;regulation of microtubule-based process#GO:0032886;sexual reproduction#GO:0019953;cell recognition#GO:0008037;regulation of cell motility#GO:2000145;binding of sperm to zona pellucida#GO:0007339;regulation of biological process#GO:0050789;regulation of microtubule-based movement#GO:0060632;regulation of cellular process#GO:0050794;reproductive process#GO:0022414;fertilization#GO:0009566 plasma membrane raft#GO:0044853;membrane microdomain#GO:0098857;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;membrane raft#GO:0045121;cell periphery#GO:0071944 HUMAN|HGNC=24690|UniProtKB=Q9BZ68 Q9BZ68 FRMD8P1 PTHR13283:SF12 KREV INTERACTION TRAPPED 1-RELATED FERM DOMAIN-CONTAINING PROTEIN FRMD8P1-RELATED regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of Wnt signaling pathway#GO:0030111;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;negative regulation of canonical Wnt signaling pathway#GO:0090090;negative regulation of cell communication#GO:0010648;regulation of canonical Wnt signaling pathway#GO:0060828;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;negative regulation of Wnt signaling pathway#GO:0030178;negative regulation of response to stimulus#GO:0048585;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HUMAN|HGNC=25223|UniProtKB=Q96H96 Q96H96 COQ2 PTHR11048:SF42 PRENYLTRANSFERASES 4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL transferase activity#GO:0016740;catalytic activity#GO:0003824;prenyltransferase activity#GO:0004659;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765 metabolic process#GO:0008152;small molecule biosynthetic process#GO:0044283;ketone metabolic process#GO:0042180;ketone biosynthetic process#GO:0042181;cellular process#GO:0009987;ubiquinone biosynthetic process#GO:0006744;small molecule metabolic process#GO:0044281;biosynthetic process#GO:0009058 mitochondrial membrane#GO:0031966;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;cell periphery#GO:0071944;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;organelle membrane#GO:0031090;mitochondrion#GO:0005739;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;acyltransferase#PC00042 HUMAN|HGNC=4385|UniProtKB=P04899 P04899 GNAI2 PTHR10218:SF73 GTP-BINDING PROTEIN ALPHA SUBUNIT GUANINE NUCLEOTIDE-BINDING PROTEIN G(I) SUBUNIT ALPHA-2 ribonucleoside triphosphate phosphatase activity#GO:0017111;molecular function regulator activity#GO:0098772;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924 cell communication#GO:0007154;adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway#GO:0007193;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cell surface receptor signaling pathway#GO:0007166;G protein-coupled adenosine receptor signaling pathway#GO:0001973;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cell-cell signaling#GO:0007267;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165 cellular anatomical structure#GO:0110165;cytoplasmic side of plasma membrane#GO:0009898;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;side of membrane#GO:0098552;intracellular anatomical structure#GO:0005622;extrinsic component of cytoplasmic side of plasma membrane#GO:0031234;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;extrinsic component of plasma membrane#GO:0019897;extrinsic component of membrane#GO:0019898;cytoplasmic side of membrane#GO:0098562 heterotrimeric G-protein#PC00117;G-protein#PC00020 Metabotropic glutamate receptor group II pathway#P00040>G-protein#P01047;Opioid prodynorphin pathway#P05916>G-protein#P06002;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Gialpha#P00712;Dopamine receptor mediated signaling pathway#P05912>Gialpha#P05958;PI3 kinase pathway#P00048>Galpha#P01199;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Galphai#P00828;Gonadotropin-releasing hormone receptor pathway#P06664>gnai#P06807;Enkephalin release#P05913>G-Protein (i)#P05974;Opioid proopiomelanocortin pathway#P05917>G-protein#P06012;Metabotropic glutamate receptor group III pathway#P00039>G-Protein#P01045;5HT1 type receptor mediated signaling pathway#P04373>G-protein#P04408;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>G-Protein#P01085;Opioid proenkephalin pathway#P05915>G-protein#P05994 HUMAN|HGNC=21251|UniProtKB=A2RUU4 A2RUU4 CLPSL1 PTHR10041:SF7 COLIPASE COLIPASE-LIKE PROTEIN 1 enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772 protein-binding activity modulator#PC00095 HUMAN|HGNC=19680|UniProtKB=Q8TDU6 Q8TDU6 GPBAR1 PTHR24246:SF31 OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR G PROTEIN-COUPLED BILE ACID RECEPTOR 1 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023 adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cell surface receptor signaling pathway#GO:0007166;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=5208|UniProtKB=P28845 P28845 HSD11B1 PTHR44279:SF1 HYDROXYSTEROID (11-BETA) DEHYDROGENASE 1-LIKE B-RELATED 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 binding#GO:0005488;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;lipid binding#GO:0008289;steroid binding#GO:0005496;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614 primary metabolic process#GO:0044238;cellular process#GO:0009987;lipid catabolic process#GO:0016042;catabolic process#GO:0009056;steroid metabolic process#GO:0008202;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;steroid catabolic process#GO:0006706 organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;membrane#GO:0016020 dehydrogenase#PC00092 HUMAN|HGNC=16673|UniProtKB=Q9BTT0 Q9BTT0 ANP32E PTHR11375:SF5 ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32 ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32 FAMILY MEMBER E phosphatase regulator activity#GO:0019208;phosphatase inhibitor activity#GO:0019212;molecular function regulator activity#GO:0098772;histone binding#GO:0042393;enzyme inhibitor activity#GO:0004857;protein binding#GO:0005515;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;binding#GO:0005488 biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of apoptotic process#GO:0042981;regulation of biological process#GO:0050789;regulation of programmed cell death#GO:0043067 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=24580|UniProtKB=Q96Q77 Q96Q77 CIB3 PTHR45791:SF7 CALCIUM AND INTEGRIN BINDING FAMILY MEMBER 2 CALCIUM AND INTEGRIN-BINDING FAMILY MEMBER 3 cation binding#GO:0043169;magnesium ion binding#GO:0000287;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094 calcium ion homeostasis#GO:0055074;monoatomic ion homeostasis#GO:0050801;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;inorganic ion homeostasis#GO:0098771;homeostatic process#GO:0042592 HUMAN|HGNC=18983|UniProtKB=Q8IUM7 Q8IUM7 NPAS4 PTHR23043:SF24 HYPOXIA-INDUCIBLE FACTOR 1 ALPHA NEURONAL PAS DOMAIN-CONTAINING PROTEIN 4 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634 basic helix-loop-helix transcription factor#PC00055;DNA-binding transcription factor#PC00218 HUMAN|HGNC=9160|UniProtKB=P11086 P11086 PNMT PTHR10867:SF18 NNMT/PNMT/TEMT FAMILY MEMBER PHENYLETHANOLAMINE N-METHYLTRANSFERASE N-methyltransferase activity#GO:0008170;transferase activity#GO:0016740;catalytic activity#GO:0003824;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 transferase#PC00220;methyltransferase#PC00155 Adrenaline and noradrenaline biosynthesis#P00001>PNMT#P00061 HUMAN|HGNC=29395|UniProtKB=Q5VU92 Q5VU92 DCAF12L1 PTHR19860:SF35 DDB1- AND CUL4-ASSOCIATED FACTOR 12-RELATED DDB1- AND CUL4-ASSOCIATED FACTOR 12-LIKE PROTEIN 1 protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461;Cul4-RING E3 ubiquitin ligase complex#GO:0080008;catalytic complex#GO:1902494;transferase complex#GO:1990234 HUMAN|HGNC=26729|UniProtKB=A6NNA2 A6NNA2 SRRM3 PTHR34755:SF2 SERINE/ARGININE REPETITIVE MATRIX PROTEIN 3-RELATED SERINE_ARGININE REPETITIVE MATRIX PROTEIN 3 mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 HUMAN|HGNC=29365|UniProtKB=Q9C0D4 Q9C0D4 ZNF518B PTHR24392:SF41 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 518B transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HUMAN|HGNC=25994|UniProtKB=Q08J23 Q08J23 NSUN2 PTHR22808:SF20 NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING RNA CYTOSINE C(5)-METHYLTRANSFERASE NSUN2 catalytic activity, acting on RNA#GO:0140098;rRNA methyltransferase activity#GO:0008649;RNA methyltransferase activity#GO:0008173;tRNA methyltransferase activity#GO:0008175;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on a rRNA#GO:0140102;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757 rRNA metabolic process#GO:0016072;mitochondrial ribosome assembly#GO:0061668;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;ribosomal large subunit assembly#GO:0000027;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;organelle assembly#GO:0070925;rRNA processing#GO:0006364;macromolecule modification#GO:0043412;RNA methylation#GO:0001510;protein-RNA complex assembly#GO:0022618;mitochondrial large ribosomal subunit assembly#GO:1902775;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;tRNA processing#GO:0008033;protein-RNA complex organization#GO:0071826;cellular process#GO:0009987;tRNA methylation#GO:0030488;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;RNA processing#GO:0006396;cellular component assembly#GO:0022607;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;macromolecule methylation#GO:0043414;RNA modification#GO:0009451;ribosomal large subunit biogenesis#GO:0042273;ribosome assembly#GO:0042255;ribosome biogenesis#GO:0042254;RNA metabolic process#GO:0016070;methylation#GO:0032259;protein-containing complex assembly#GO:0065003;tRNA wobble base modification#GO:0002097;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;tRNA modification#GO:0006400;ribonucleoprotein complex biogenesis#GO:0022613 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 RNA methyltransferase#PC00033 HUMAN|HGNC=28680|UniProtKB=Q9BUX1 Q9BUX1 CHAC1 PTHR12192:SF26 CATION TRANSPORT PROTEIN CHAC-RELATED GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOTRANSFERASE 1 catalytic activity#GO:0003824;lyase activity#GO:0016829 modified amino acid metabolic process#GO:0006575;glutathione metabolic process#GO:0006749;sulfur compound metabolic process#GO:0006790;metabolic process#GO:0008152;cellular process#GO:0009987;sulfur compound catabolic process#GO:0044273;catabolic process#GO:0009056 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=6938|UniProtKB=Q9GZX3 Q9GZX3 CHST6 PTHR10704:SF4 CARBOHYDRATE SULFOTRANSFERASE CARBOHYDRATE SULFOTRANSFERASE 6 transferase activity, transferring sulphur-containing groups#GO:0016782;sulfotransferase activity#GO:0008146;transferase activity#GO:0016740;catalytic activity#GO:0003824 carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;proteoglycan metabolic process#GO:0006029;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;amino sugar metabolic process#GO:0006040;biosynthetic process#GO:0009058;proteoglycan biosynthetic process#GO:0030166;sulfur compound metabolic process#GO:0006790;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135 Golgi apparatus subcompartment#GO:0098791;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984 metabolite interconversion enzyme#PC00262;transferase#PC00220 HUMAN|HGNC=5876|UniProtKB=A0A0B4J1U3 A0A0B4J1U3 IGLV1-36 PTHR23267:SF347 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN LAMBDA VARIABLE 1-36 immune system process#GO:0002376;immune response#GO:0006955;response to stimulus#GO:0050896 protein-containing complex#GO:0032991 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=12713|UniProtKB=P49754 P49754 VPS41 PTHR12616:SF1 VACUOLAR PROTEIN SORTING VPS41 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 41 HOMOLOG protein-membrane adaptor activity#GO:0043495;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 macroautophagy#GO:0016236;organelle membrane fusion#GO:0090174;membrane organization#GO:0061024;vesicle-mediated transport#GO:0016192;organelle fusion#GO:0048284;cellular process#GO:0009987;autophagy#GO:0006914;establishment of localization in cell#GO:0051649;response to stress#GO:0006950;organelle organization#GO:0006996;membrane fusion#GO:0061025;response to nutrient levels#GO:0031667;vesicle organization#GO:0016050;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;transport#GO:0006810;cellular response to nutrient levels#GO:0031669;vacuolar transport#GO:0007034;intracellular transport#GO:0046907;metabolic process#GO:0008152;cellular response to starvation#GO:0009267;vesicle fusion#GO:0006906;catabolic process#GO:0009056;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular component organization#GO:0016043;response to starvation#GO:0042594;process utilizing autophagic mechanism#GO:0061919;cellular localization#GO:0051641;localization#GO:0051179;cellular response to stress#GO:0033554 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;vacuole#GO:0005773;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;late endosome#GO:0005770;membrane#GO:0016020;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;vesicle tethering complex#GO:0099023;vacuolar membrane#GO:0005774 membrane traffic protein#PC00150 HUMAN|HGNC=22429|UniProtKB=Q8TAQ9 Q8TAQ9 SUN3 PTHR12911:SF24 SAD1/UNC-84-LIKE PROTEIN-RELATED SUN DOMAIN-CONTAINING PROTEIN 3 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;protein-membrane adaptor activity#GO:0043495 organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;membrane protein complex#GO:0098796;membrane#GO:0016020;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 microtubule or microtubule-binding cytoskeletal protein#PC00157;cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HUMAN|HGNC=18551|UniProtKB=Q9BY27 Q9BY27 DGCR6L PTHR13054:SF6 DIGEORGE SYNDROME CRITICAL REGION 6 DGCR6 FAMILY MEMBER PROTEIN DGCR6L nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=28437|UniProtKB=Q6P087 Q6P087 RPUSD3 PTHR21600:SF49 MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE MITOCHONDRIAL MRNA PSEUDOURIDINE SYNTHASE RPUSD3 intramolecular transferase activity#GO:0016866;catalytic activity#GO:0003824;isomerase activity#GO:0016853 rRNA processing#GO:0006364;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;ribosome biogenesis#GO:0042254;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;pseudouridine synthesis#GO:0001522;rRNA modification#GO:0000154;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 RNA processing factor#PC00147 HUMAN|HGNC=1728|UniProtKB=P30260 P30260 CDC27 PTHR12558:SF13 CELL DIVISION CYCLE 16,23,27 CELL DIVISION CYCLE PROTEIN 27 HOMOLOG protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;enzyme-substrate adaptor activity#GO:0140767 macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;mitotic cell cycle phase transition#GO:0044772;cell cycle phase transition#GO:0044770;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;mitotic cell cycle#GO:0000278;cell division#GO:0051301;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;protein modification process#GO:0036211;cell cycle#GO:0007049;ubiquitin-dependent protein catabolic process#GO:0006511;mitotic cell cycle process#GO:1903047;macromolecule metabolic process#GO:0043170;regulation of chromosome organization#GO:0033044;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;post-translational protein modification#GO:0043687;biological regulation#GO:0065007;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;anaphase-promoting complex-dependent catabolic process#GO:0031145;metaphase/anaphase transition of mitotic cell cycle#GO:0007091;protein modification by small protein conjugation or removal#GO:0070647;regulation of sister chromatid segregation#GO:0033045;regulation of cell cycle#GO:0051726;regulation of cellular component organization#GO:0051128;regulation of organelle organization#GO:0033043;cell cycle process#GO:0022402;regulation of biological process#GO:0050789;protein modification by small protein conjugation#GO:0032446;regulation of chromosome segregation#GO:0051983;metaphase/anaphase transition of cell cycle#GO:0044784;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;proteasomal protein catabolic process#GO:0010498;regulation of cell cycle process#GO:0010564;protein ubiquitination#GO:0016567;cellular process#GO:0009987 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear ubiquitin ligase complex#GO:0000152;cellular anatomical structure#GO:0110165;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;anaphase-promoting complex#GO:0005680;nucleus#GO:0005634 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=1689|UniProtKB=P13987 P13987 CD59 PTHR10036:SF24 CD59 GLYCOPROTEIN CD59 GLYCOPROTEIN protein binding#GO:0005515;binding#GO:0005488;complement binding#GO:0001848 regulation of immune effector process#GO:0002697;regulation of response to stimulus#GO:0048583;negative regulation of immune response#GO:0050777;regulation of immune response#GO:0050776;regulation of immune system process#GO:0002682;negative regulation of response to stimulus#GO:0048585;negative regulation of immune system process#GO:0002683;biological regulation#GO:0065007;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HUMAN|HGNC=31291|UniProtKB=A6NMS3 A6NMS3 OR5K4 PTHR26452:SF795 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5K4 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 sensory perception of chemical stimulus#GO:0007606;sensory perception#GO:0007600;nervous system process#GO:0050877;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;system process#GO:0003008 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=5399|UniProtKB=P80217 P80217 IFI35 PTHR15225:SF1 INTERFERON-INDUCED PROTEIN 35/NMI N-MYC/STAT INTERACTING PROTEIN INTERFERON-INDUCED 35 KDA PROTEIN organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 transcription cofactor#PC00217 HUMAN|HGNC=13618|UniProtKB=Q8IX29 Q8IX29 FBXO16 PTHR46857:SF2 EPITHELIAL CELL-TRANSFORMING SEQUENCE 2 ONCOGENE-LIKE F-BOX ONLY PROTEIN 16 HUMAN|HGNC=29588|UniProtKB=Q5BJE1 Q5BJE1 CCDC178 PTHR35088:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 178 COILED-COIL DOMAIN-CONTAINING PROTEIN 178 HUMAN|HGNC=29166|UniProtKB=P0C7N5 P0C7N5 OR8U9 PTHR48018:SF91 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 8U1-RELATED molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;nervous system process#GO:0050877;sensory perception#GO:0007600;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052;regulation of cellular process#GO:0050794;sensory perception of smell#GO:0007608;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;cellular process#GO:0009987;signal transduction#GO:0007165 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=12649|UniProtKB=O95292 O95292 VAPB PTHR10809:SF12 VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN B_C protein-membrane adaptor activity#GO:0043495;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;endoplasmic reticulum organization#GO:0007029;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;endoplasmic reticulum membrane organization#GO:0090158;cellular component organization or biogenesis#GO:0071840 plasma membrane#GO:0005886;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cell periphery#GO:0071944;membrane#GO:0016020;organelle membrane#GO:0031090;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827 membrane traffic protein#PC00150;membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=21566|UniProtKB=Q5JXM2 Q5JXM2 METTL24 PTHR32026:SF10 METHYLTRANSFERASE-LIKE PROTEIN 24 METHYLTRANSFERASE-LIKE PROTEIN 24-RELATED methyltransferase#PC00155;transferase#PC00220 HUMAN|HGNC=16840|UniProtKB=Q9H944 Q9H944 MED20 PTHR12465:SF0 UBIQUITIN SPECIFIC PROTEASE HOMOLOG 49 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 20 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription coactivator activity#GO:0003713 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;core mediator complex#GO:0070847;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=1401|UniProtKB=Q02641 Q02641 CACNB1 PTHR11824:SF17 VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1 voltage-gated ion channel#PC00241 Alzheimer disease-amyloid secretase pathway#P00003>L-type calcium channels#P00082;Beta1 adrenergic receptor signaling pathway#P04377>Ca2+ channel#P04438;5HT2 type receptor mediated signaling pathway#P04374>Ca2+ channel#P04411;Nicotinic acetylcholine receptor signaling pathway#P00044>Ca2+ channel#P01096;Oxytocin receptor mediated signaling pathway#P04391>Ca2+ channel#P04535;Beta2 adrenergic receptor signaling pathway#P04378>Ca2+ channel#P04445;Metabotropic glutamate receptor group II pathway#P00040>Ca2+#P01051;Thyrotropin-releasing hormone receptor signaling pathway#P04394>Ca2+ channel#P04587;Metabotropic glutamate receptor group III pathway#P00039>Ca2+#P01041 HUMAN|HGNC=15819|UniProtKB=Q15327 Q15327 ANKRD1 PTHR24126:SF7 ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 1 protein binding#GO:0005515;RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629;DNA-binding transcription factor binding#GO:0140297;binding#GO:0005488;transcription factor binding#GO:0008134 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=27570|UniProtKB=Q7Z6M3 Q7Z6M3 MILR1 PTHR11481:SF58 IMMUNOGLOBULIN FC RECEPTOR ALLERGIN-1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;signal transduction#GO:0007165;immune response#GO:0006955;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;immune system process#GO:0002376;cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154 external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;cell surface#GO:0009986 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=21539|UniProtKB=Q9BX46 Q9BX46 RBM24 PTHR48024:SF10 GEO13361P1-RELATED RNA-BINDING PROTEIN 24 mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA 3'-UTR binding#GO:0003730;RNA binding#GO:0003723 regulation of RNA stability#GO:0043487;regulation of RNA metabolic process#GO:0051252;negative regulation of catabolic process#GO:0009895;positive regulation of biosynthetic process#GO:0009891;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of cell differentiation#GO:0045595;positive regulation of developmental process#GO:0051094;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;negative regulation of RNA catabolic process#GO:1902369;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;positive regulation of gene expression#GO:0010628;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA splicing#GO:0043484;regulation of mRNA processing#GO:0050684;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biological quality#GO:0065008;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of alternative mRNA splicing, via spliceosome#GO:0000381;RNA stabilization#GO:0043489;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of biological process#GO:0050789;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;regulation of mRNA stability#GO:0043488;negative regulation of metabolic process#GO:0009892;negative regulation of RNA metabolic process#GO:0051253;positive regulation of cell differentiation#GO:0045597;regulation of mRNA metabolic process#GO:1903311;positive regulation of biological process#GO:0048518;mRNA stabilization#GO:0048255;positive regulation of macromolecule metabolic process#GO:0010604 cytosol#GO:0005829;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=2527|UniProtKB=P07858 P07858 CTSB PTHR12411:SF16 CYSTEINE PROTEASE FAMILY C1-RELATED CATHEPSIN B catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;cysteine-type endopeptidase activity#GO:0004197;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 cellular process#GO:0009987;primary metabolic process#GO:0044238;catabolic process#GO:0009056;protein catabolic process#GO:0030163;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 lysosome#GO:0005764;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;vacuole#GO:0005773;cellular anatomical structure#GO:0110165;organelle#GO:0043226;extracellular region#GO:0005576;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;lytic vacuole#GO:0000323 protein modifying enzyme#PC00260;cysteine protease#PC00081;protease#PC00190 HUMAN|HGNC=16367|UniProtKB=Q14585 Q14585 ZNF345 PTHR24393:SF100 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 345-RELATED sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;sequence-specific DNA binding#GO:0043565;DNA-binding transcription activator activity#GO:0001216;transcription regulator activity#GO:0140110;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulatory region nucleic acid binding#GO:0001067 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HUMAN|HGNC=16772|UniProtKB=Q07627 Q07627 KRTAP1-1 PTHR23262:SF186 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 1-1 structural protein#PC00211 HUMAN|HGNC=12469|UniProtKB=P22314 P22314 UBA1 PTHR10953:SF155 UBIQUITIN-ACTIVATING ENZYME E1 UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 1 thiosulfate-cyanide sulfurtransferase activity#GO:0004792;sulfurtransferase activity#GO:0016783;transferase activity, transferring sulphur-containing groups#GO:0016782;ligase activity, forming carbon-sulfur bonds#GO:0016877;ATP-dependent activity#GO:0140657;catalytic activity, acting on a protein#GO:0140096;nucleotidyltransferase activity#GO:0016779;transferase activity#GO:0016740;catalytic activity#GO:0003824;ligase activity#GO:0016874;transferase activity, transferring phosphorus-containing groups#GO:0016772;ubiquitin-like modifier activating enzyme activity#GO:0008641 response to stress#GO:0006950;cellular process#GO:0009987;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;protein modification process#GO:0036211;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;response to stimulus#GO:0050896;protein modification by small protein conjugation or removal#GO:0070647;modification-dependent macromolecule catabolic process#GO:0043632;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 Ubiquitin proteasome pathway#P00060>E3#P01490;Ubiquitin proteasome pathway#P00060>E1#P01492 HUMAN|HGNC=25944|UniProtKB=Q9BUE0 Q9BUE0 MED18 PTHR13321:SF2 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION, SUBUNIT 18 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 18 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;regulation of DNA-templated transcription initiation#GO:2000142;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of transcription by RNA polymerase II#GO:0045944 intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;core mediator complex#GO:0070847;RNA polymerase II transcription regulator complex#GO:0090575;intracellular anatomical structure#GO:0005622;mediator complex#GO:0016592;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031;general transcription factor#PC00259 HUMAN|HGNC=21636|UniProtKB=Q6ZU52 Q6ZU52 KIAA0408 PTHR15705:SF1 MCG7194, ISOFORM CRA_A RIKEN CDNA 9330159F19 GENE HUMAN|HGNC=6776|UniProtKB=O75444 O75444 MAF PTHR10129:SF9 TRANSCRIPTION FACTOR MAF TRANSCRIPTION FACTOR MAF sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677 camera-type eye development#GO:0043010;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;visual system development#GO:0150063;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;developmental process#GO:0032502;sensory organ development#GO:0007423;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;epithelium development#GO:0060429;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;epithelial cell differentiation#GO:0030855;tissue development#GO:0009888;animal gross anatomical part developmental process#GO:0160108;eye development#GO:0001654;regulation of biological process#GO:0050789;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;lens development in camera-type eye#GO:0002088;multicellular organism development#GO:0007275;animal organ development#GO:0048513;cellular process#GO:0009987;sensory system development#GO:0048880 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;basic leucine zipper transcription factor#PC00056 HUMAN|HGNC=402|UniProtKB=P00352 P00352 ALDH1A1 PTHR11699:SF140 ALDEHYDE DEHYDROGENASE-RELATED ALDEHYDE DEHYDROGENASE 1A1 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor#GO:0016620;aldehyde dehydrogenase (NAD+) activity#GO:0004029;oxidoreductase activity, acting on the aldehyde or oxo group of donors#GO:0016903;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 aldehyde metabolic process#GO:0006081;cellular process#GO:0009987;terpenoid biosynthetic process#GO:0016114;lipid biosynthetic process#GO:0008610;hormone metabolic process#GO:0042445;aldehyde catabolic process#GO:0046185;biological regulation#GO:0065007;biosynthetic process#GO:0009058;metabolic process#GO:0008152;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;diterpenoid biosynthetic process#GO:0016102;monocarboxylic acid biosynthetic process#GO:0072330;retinoid metabolic process#GO:0001523;diterpenoid metabolic process#GO:0016101;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;monocarboxylic acid metabolic process#GO:0032787;regulation of hormone levels#GO:0010817;carboxylic acid biosynthetic process#GO:0046394;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;oxoacid metabolic process#GO:0043436;isoprenoid biosynthetic process#GO:0008299;terpenoid metabolic process#GO:0006721;isoprenoid metabolic process#GO:0006720;regulation of biological quality#GO:0065008 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;dehydrogenase#PC00092 5-Hydroxytryptamine degredation#P04372>Aldehyde Dehydrogenase#P04402 HUMAN|HGNC=936|UniProtKB=Q92934 Q92934 BAD PTHR28540:SF1 BCL2-ASSOCIATED AGONIST OF CELL DEATH BCL2-ASSOCIATED AGONIST OF CELL DEATH molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;peptidase activator activity#GO:0016504;peptidase regulator activity#GO:0061134;endopeptidase regulator activity#GO:0061135;enzyme activator activity#GO:0008047 cell communication#GO:0007154;response to stimulus#GO:0050896;extrinsic apoptotic signaling pathway#GO:0097191;regulation of cellular process#GO:0050794;positive regulation of programmed cell death#GO:0043068;signaling#GO:0023052;regulation of programmed cell death#GO:0043067;programmed cell death#GO:0012501;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;apoptotic process#GO:0006915;cell death#GO:0008219;positive regulation of apoptotic process#GO:0043065;apoptotic signaling pathway#GO:0097190;cell surface receptor signaling pathway#GO:0007166;regulation of apoptotic process#GO:0042981;biological regulation#GO:0065007;signal transduction#GO:0007165;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;mitochondrion#GO:0005739 CCKR signaling map#P06959>BAD#P07210 HUMAN|HGNC=11784|UniProtKB=P07204 P07204 THBD PTHR24036:SF5 SKELETOR-RELATED THROMBOMODULIN transmembrane signal receptor#PC00197 Blood coagulation#P00011>Thrombomodulin#P00457 HUMAN|HGNC=9075|UniProtKB=P08697 P08697 SERPINF2 PTHR11461:SF20 SERINE PROTEASE INHIBITOR, SERPIN ALPHA-2-ANTIPLASMIN molecular function inhibitor activity#GO:0140678;serine-type endopeptidase inhibitor activity#GO:0004867;enzyme regulator activity#GO:0030234;peptidase regulator activity#GO:0061134;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414;molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866;enzyme inhibitor activity#GO:0004857 regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;regulation of coagulation#GO:0050818;positive regulation of multicellular organismal process#GO:0051240;positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789;positive regulation of coagulation#GO:0050820 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease inhibitor#PC00191 Plasminogen activating cascade#P00050>alpha2 antiplasmin#P01264;Blood coagulation#P00011>alpha2-antiplasmin#P00428 HUMAN|HGNC=6083|UniProtKB=O15503 O15503 INSIG1 PTHR15301:SF11 INSULIN-INDUCED GENE 1 INSULIN-INDUCED GENE 1 PROTEIN cellular response to peptide hormone stimulus#GO:0071375;intracellular signal transduction#GO:0035556;response to nitrogen compound#GO:1901698;localization#GO:0051179;cell communication#GO:0007154;regulation of signal transduction#GO:0009966;cellular response to nitrogen compound#GO:1901699;macromolecule localization#GO:0033036;intracellular protein localization#GO:0008104;sterol metabolic process#GO:0016125;steroid biosynthetic process#GO:0006694;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;regulation of response to stress#GO:0080134;signaling#GO:0023052;cellular response to endogenous stimulus#GO:0071495;small molecule metabolic process#GO:0044281;response to endogenous stimulus#GO:0009719;regulation of cellular response to stress#GO:0080135;negative regulation of intracellular signal transduction#GO:1902532;cellular response to stress#GO:0033554;response to oxygen-containing compound#GO:1901700;regulation of intracellular signal transduction#GO:1902531;steroid metabolic process#GO:0008202;sterol biosynthetic process#GO:0016126;response to lipid#GO:0033993;response to chemical#GO:0042221;response to stress#GO:0006950;response to hormone#GO:0009725;metabolic process#GO:0008152;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;protein localization to organelle#GO:0033365;cellular response to stimulus#GO:0051716;response to insulin#GO:0032868;primary metabolic process#GO:0044238;SREBP signaling pathway#GO:0032933;response to peptide hormone#GO:0043434;biological regulation#GO:0065007;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;negative regulation of response to stimulus#GO:0048585;secondary alcohol biosynthetic process#GO:1902653;cholesterol metabolic process#GO:0008203;regulation of response to stimulus#GO:0048583;cellular response to insulin stimulus#GO:0032869;negative regulation of cellular process#GO:0048523;secondary alcohol metabolic process#GO:1902652;cellular response to hormone stimulus#GO:0032870;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of cell communication#GO:0010648;cellular localization#GO:0051641;regulation of signaling#GO:0023051;cellular response to chemical stimulus#GO:0070887;negative regulation of signaling#GO:0023057;negative regulation of signal transduction#GO:0009968;cellular response to lipid#GO:0071396;cholesterol biosynthetic process#GO:0006695;cellular process#GO:0009987;signal transduction#GO:0007165;alcohol biosynthetic process#GO:0046165;cellular response to oxygen-containing compound#GO:1901701;alcohol metabolic process#GO:0006066 membrane#GO:0016020;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;organelle membrane#GO:0031090;endoplasmic reticulum protein-containing complex#GO:0140534;membrane protein complex#GO:0098796;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984 HUMAN|HGNC=19752|UniProtKB=Q8N3X1 Q8N3X1 FNBP4 PTHR46697:SF1 FORMIN-BINDING PROTEIN 4 FORMIN-BINDING PROTEIN 4 HUMAN|Ensembl=ENSG00000267635.1|UniProtKB=A0A140TA67 A0A140TA67 KRTAP9-7 PTHR23262:SF133 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 9-6-RELATED structural protein#PC00211 HUMAN|HGNC=4540|UniProtKB=P49682 P49682 CXCR3 PTHR10489:SF671 CELL ADHESION MOLECULE C-X-C CHEMOKINE RECEPTOR TYPE 3 transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488;protein binding#GO:0005515;molecular transducer activity#GO:0060089;cytokine receptor activity#GO:0004896;cytokine binding#GO:0019955;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;immune receptor activity#GO:0140375 signal transduction#GO:0007165;immune response#GO:0006955;cellular process#GO:0009987;taxis#GO:0042330;response to chemical#GO:0042221;cell migration#GO:0016477;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124;response to external stimulus#GO:0009605;calcium-mediated signaling#GO:0019722;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;cell motility#GO:0048870;regulation of cellular process#GO:0050794;signaling#GO:0023052;locomotion#GO:0040011;cellular response to chemical stimulus#GO:0070887;positive regulation of cytosolic calcium ion concentration#GO:0007204;immune system process#GO:0002376;chemotaxis#GO:0006935;cell communication#GO:0007154;cell chemotaxis#GO:0060326;regulation of biological quality#GO:0065008;intracellular signal transduction#GO:0035556 cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell surface#GO:0009986 cell adhesion molecule#PC00069 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CHKR#P00854 HUMAN|HGNC=13601|UniProtKB=Q9UKA2 Q9UKA2 FBXL4 PTHR13318:SF152 PARTNER OF PAIRED, ISOFORM B-RELATED F-BOX_LRR-REPEAT PROTEIN 4 primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511 catalytic complex#GO:1902494;transferase complex#GO:1990234;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;SCF ubiquitin ligase complex#GO:0019005;intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461 HUMAN|HGNC=26049|UniProtKB=Q9BU19 Q9BU19 ZNF692 PTHR24390:SF105 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 692 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677 regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 DNA-binding transcription factor#PC00218;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=3403|UniProtKB=P32856 P32856 STX2 PTHR19957:SF36 SYNTAXIN SYNTAXIN-2 SNAP receptor activity#GO:0005484;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 protein transport#GO:0015031;secretion by cell#GO:0032940;cellular localization#GO:0051641;secretion#GO:0046903;localization#GO:0051179;vesicle fusion#GO:0006906;export from cell#GO:0140352;cellular component organization#GO:0016043;vesicle organization#GO:0016050;exocytosis#GO:0006887;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907;organelle membrane fusion#GO:0090174;membrane organization#GO:0061024;vesicle-mediated transport#GO:0016192;organelle fusion#GO:0048284;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;macromolecule localization#GO:0033036;organelle organization#GO:0006996;membrane fusion#GO:0061025 cell periphery#GO:0071944;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;SNARE complex#GO:0031201;endomembrane system#GO:0012505;intracellular anatomical structure#GO:0005622 SNARE protein#PC00034 Synaptic vesicle trafficking#P05734>Syntaxin 1/2#P05772;Nicotinic acetylcholine receptor signaling pathway#P00044>SNARE Complex#P01091;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>SNARE Complex#P01079 HUMAN|HGNC=9874|UniProtKB=Q9UJF2 Q9UJF2 RASAL2 PTHR10194:SF52 RAS GTPASE-ACTIVATING PROTEINS RAS GTPASE-ACTIVATING PROTEIN NGAP GTPase-activating protein#PC00257 EGF receptor signaling pathway#P00018>GAP#P00546 HUMAN|HGNC=4426|UniProtKB=Q08378 Q08378 GOLGA3 PTHR18902:SF26 NUCLEAR MITOTIC APPARATUS PROTEIN 1-RELATED GOLGIN SUBFAMILY A MEMBER 3 membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;intracellular organelle#GO:0043229;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;membrane#GO:0016020 cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=2958|UniProtKB=Q92874 Q92874 DNASE1L2 PTHR11371:SF29 DEOXYRIBONUCLEASE DEOXYRIBONUCLEASE-1-LIKE 2 catalytic activity, acting on a nucleic acid#GO:0140640;DNA endonuclease activity, producing 5'-phosphomonoesters#GO:0016888;catalytic activity#GO:0003824;DNA nuclease activity#GO:0004536;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on DNA#GO:0140097;endonuclease activity#GO:0004519;binding#GO:0005488;nucleic acid binding#GO:0003676;hydrolase activity#GO:0016787;DNA endonuclease activity#GO:0004520;DNA binding#GO:0003677;nuclease activity#GO:0004518 DNA metabolic process#GO:0006259;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;DNA catabolic process#GO:0006308;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound catabolic process#GO:0034655;nucleic acid catabolic process#GO:0141188;cellular process#GO:0009987;catabolic process#GO:0009056;nucleobase-containing compound metabolic process#GO:0006139 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 endodeoxyribonuclease#PC00093 HUMAN|HGNC=3114|UniProtKB=Q14209 Q14209 E2F2 PTHR12081:SF50 TRANSCRIPTION FACTOR E2F TRANSCRIPTION FACTOR E2F2 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;winged helix/forkhead transcription factor#PC00246;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=27568|UniProtKB=Q2M2W7 Q2M2W7 C17orf58 PTHR35967:SF1 UPF0450 PROTEIN C17ORF58 UPF0450 PROTEIN C17ORF58 HUMAN|HGNC=6950|UniProtKB=P33993 P33993 MCM7 PTHR11630:SF26 DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER DNA REPLICATION LICENSING FACTOR MCM7 isomerase activity#GO:0016853;DNA helicase activity#GO:0003678;catalytic activity, acting on DNA#GO:0140097;helicase activity#GO:0004386;macromolecular conformation isomerase activity#GO:0120543;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;DNA binding#GO:0003677;ATP-dependent activity, acting on DNA#GO:0008094;single-stranded DNA binding#GO:0003697;ATP-dependent activity#GO:0140657;binding#GO:0005488;nucleic acid binding#GO:0003676 recombinational repair#GO:0000725;cellular response to stress#GO:0033554;DNA-templated DNA replication#GO:0006261;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;DNA replication#GO:0006260;cellular response to stimulus#GO:0051716;double-strand break repair via homologous recombination#GO:0000724;response to stimulus#GO:0050896;DNA strand elongation involved in DNA replication#GO:0006271;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA recombination#GO:0006310;DNA damage response#GO:0006974;DNA replication initiation#GO:0006270;macromolecule metabolic process#GO:0043170;double-strand break repair#GO:0006302;response to stress#GO:0006950;double-strand break repair via break-induced replication#GO:0000727;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139 MCM complex#GO:0042555;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 DNA metabolism protein#PC00009 HUMAN|HGNC=4689|UniProtKB=Q02846 Q02846 GUCY2D PTHR11920:SF228 GUANYLYL CYCLASE RETINAL GUANYLYL CYCLASE 1 molecular transducer activity#GO:0060089;lyase activity#GO:0016829;peptide receptor activity#GO:0001653;signaling receptor activity#GO:0038023;guanylate cyclase activity#GO:0004383;catalytic activity#GO:0003824;phosphorus-oxygen lyase activity#GO:0016849;cyclase activity#GO:0009975 purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;nucleotide biosynthetic process#GO:0009165;ribonucleotide metabolic process#GO:0009259;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;cyclic nucleotide biosynthetic process#GO:0009190;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;signaling#GO:0023052;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;regulation of biological process#GO:0050789;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;cell surface receptor signaling pathway#GO:0007166;cyclic purine nucleotide metabolic process#GO:0052652;ribose phosphate biosynthetic process#GO:0046390;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;signal transduction#GO:0007165;receptor guanylyl cyclase signaling pathway#GO:0007168;cGMP biosynthetic process#GO:0006182;enzyme-linked receptor protein signaling pathway#GO:0007167;organophosphate biosynthetic process#GO:0090407;cell communication#GO:0007154;regulation of cellular process#GO:0050794;nucleoside phosphate metabolic process#GO:0006753;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;nucleoside phosphate biosynthetic process#GO:1901293;cyclic nucleotide metabolic process#GO:0009187;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;cGMP metabolic process#GO:0046068;carbohydrate derivative metabolic process#GO:1901135 organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;photoreceptor cell cilium#GO:0097733;cell periphery#GO:0071944;neuron projection#GO:0043005;membrane#GO:0016020;9+0 non-motile cilium#GO:0097731;ciliary membrane#GO:0060170;plasma membrane#GO:0005886;plasma membrane region#GO:0098590;cilium#GO:0005929;non-motile cilium#GO:0097730;membrane-bounded organelle#GO:0043227;cell projection membrane#GO:0031253;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;photoreceptor outer segment#GO:0001750 lyase#PC00144;guanylate cyclase#PC00114 CCKR signaling map#P06959>Guanylate cyclase#P07116 HUMAN|HGNC=34211|UniProtKB=A8MX34 A8MX34 KRTAP29-1 PTHR23262:SF91 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 29-1 structural protein#PC00211 HUMAN|HGNC=16618|UniProtKB=P82930 P82930 MRPS34 PTHR28589:SF1 28S RIBOSOMAL PROTEIN S34, MITOCHONDRIAL SMALL RIBOSOMAL SUBUNIT PROTEIN MS34 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 translation#GO:0006412;metabolic process#GO:0008152;mitochondrial gene expression#GO:0140053;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;gene expression#GO:0010467;mitochondrial translation#GO:0032543;protein biosynthetic process#GO:0160307 organellar ribosome#GO:0000313;intracellular anatomical structure#GO:0005622;mitochondrial ribosome#GO:0005761;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;small ribosomal subunit#GO:0015935;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;ribosome#GO:0005840;mitochondrion#GO:0005739;mitochondrial small ribosomal subunit#GO:0005763;membraneless organelle#GO:0043228;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974 translational protein#PC00263;ribosomal protein#PC00202 HUMAN|HGNC=783|UniProtKB=P18846 P18846 ATF1 PTHR45879:SF2 CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN B CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-1 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;intracellular signaling cassette#GO:0141124;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;signal transduction#GO:0007165;cellular process#GO:0009987;cell communication#GO:0007154;regulation of DNA-templated transcription#GO:0006355;intracellular signal transduction#GO:0035556;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716 membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575 basic leucine zipper transcription factor#PC00056;DNA-binding transcription factor#PC00218 Apoptosis signaling pathway#P00006>ATF#P00302;p38 MAPK pathway#P05918>ATF1#P06019 HUMAN|HGNC=2361|UniProtKB=P52943 P52943 CRIP2 PTHR46074:SF2 CYSTEINE-RICH PROTEIN CRIP FAMILY MEMBER CYSTEINE-RICH PROTEIN 2 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=3557|UniProtKB=P05413 P05413 FABP3 PTHR11955:SF61 FATTY ACID BINDING PROTEIN FATTY ACID-BINDING PROTEIN, HEART binding#GO:0005488;carboxylic acid binding#GO:0031406;anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167;organic acid binding#GO:0043177;fatty acid binding#GO:0005504;lipid binding#GO:0008289 monocarboxylic acid transport#GO:0015718;fatty acid transport#GO:0015908;localization#GO:0051179;establishment of localization#GO:0051234;transport#GO:0006810;organic acid transport#GO:0015849;carboxylic acid transport#GO:0046942;lipid localization#GO:0010876;lipid transport#GO:0006869;macromolecule localization#GO:0033036 nucleus#GO:0005634;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 transfer/carrier protein#PC00219 HUMAN|HGNC=41908|UniProtKB=Q8TEE9 Q8TEE9 SAP25 PTHR39231:SF1 HISTONE DEACETYLASE COMPLEX SUBUNIT SAP25 HISTONE DEACETYLASE COMPLEX SUBUNIT SAP25 histone modifying enzyme#PC00261;chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=26810|UniProtKB=Q63HQ2 Q63HQ2 EGFLAM PTHR15036:SF88 PIKACHURIN-LIKE PROTEIN PIKACHURIN signal transduction#GO:0007165;cellular process#GO:0009987;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;nervous system development#GO:0007399;developmental process#GO:0032502;multicellular organism development#GO:0007275;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;animal gross anatomical part developmental process#GO:0160108;cell communication#GO:0007154;anatomical structure development#GO:0048856;system development#GO:0048731 extracellular region#GO:0005576;cell junction#GO:0030054;basement membrane#GO:0005604;cell periphery#GO:0071944;external encapsulating structure#GO:0030312;membrane#GO:0016020;extracellular matrix#GO:0031012;plasma membrane#GO:0005886;synapse#GO:0045202;cellular anatomical structure#GO:0110165 cell adhesion molecule#PC00069 HUMAN|HGNC=25464|UniProtKB=Q8NAA4 Q8NAA4 ATG16L2 PTHR19878:SF7 AUTOPHAGY PROTEIN 16-LIKE PROTEIN ATG16L2 protein-membrane adaptor activity#GO:0043495;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 cellular component organization or biogenesis#GO:0071840;vacuole organization#GO:0007033;autophagosome assembly#GO:0000045;process utilizing autophagic mechanism#GO:0061919;organelle assembly#GO:0070925;metabolic process#GO:0008152;catabolic process#GO:0009056;cellular component assembly#GO:0022607;macroautophagy#GO:0016236;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;autophagy#GO:0006914;cellular process#GO:0009987;autophagosome organization#GO:1905037 autophagosome#GO:0005776;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;autophagosome membrane#GO:0000421;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;phagophore assembly site#GO:0000407;transferase complex#GO:1990234;vacuolar membrane#GO:0005774;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane#GO:0016020;protein-containing complex#GO:0032991;vacuole#GO:0005773;cytoplasm#GO:0005737 HUMAN|HGNC=26591|UniProtKB=Q5FWE3 Q5FWE3 PRRT3 PTHR47400:SF1 PROLINE-RICH TRANSMEMBRANE PROTEIN 3 PROLINE-RICH TRANSMEMBRANE PROTEIN 3 HUMAN|HGNC=8986|UniProtKB=P11309 P11309 PIM1 PTHR22984:SF29 SERINE/THREONINE-PROTEIN KINASE PIM SERINE_THREONINE-PROTEIN KINASE PIM-1 catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 regulation of cell communication#GO:0010646;regulation of cell cycle#GO:0051726;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;positive regulation of TOR signaling#GO:0032008;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;negative regulation of apoptotic process#GO:0043066;regulation of mitotic cell cycle#GO:0007346;regulation of TOR signaling#GO:0032006;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;negative regulation of programmed cell death#GO:0043069;positive regulation of TORC1 signaling#GO:1904263;regulation of TORC1 signaling#GO:1903432;regulation of apoptotic process#GO:0042981;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;negative regulation of cellular process#GO:0048523 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=4514|UniProtKB=Q9P1P5 Q9P1P5 TAAR2 PTHR24249:SF413 HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR TRACE AMINE-ASSOCIATED RECEPTOR 2 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023 biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021 HUMAN|HGNC=28054|UniProtKB=Q5EBL2 Q5EBL2 ZNF628 PTHR24384:SF254 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED ZINC FINGER PROTEIN 628 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 DNA-binding transcription factor#PC00218 HUMAN|HGNC=29850|UniProtKB=O75113 O75113 N4BP1 PTHR12876:SF26 N4BP1-RELATED NEDD4-BINDING PROTEIN 1 catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;RNA endonuclease activity#GO:0004521;catalytic activity, acting on RNA#GO:0140098;mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;nuclease activity#GO:0004518;RNA binding#GO:0003723 regulation of post-translational protein modification#GO:1901873;positive regulation of metabolic process#GO:0009893;regulation of biological quality#GO:0065008;negative regulation of protein ubiquitination#GO:0031397;negative regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032435;negative regulation of metabolic process#GO:0009892;regulation of mRNA stability#GO:0043488;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;regulation of protein modification by small protein conjugation or removal#GO:1903320;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;regulation of mRNA metabolic process#GO:1903311;negative regulation of ubiquitin-dependent protein catabolic process#GO:2000059;mRNA destabilization#GO:0061157;positive regulation of mRNA metabolic process#GO:1903313;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;positive regulation of macromolecule metabolic process#GO:0010604;regulation of proteasomal protein catabolic process#GO:0061136;negative regulation of protein catabolic process#GO:0042177;negative regulation of macromolecule biosynthetic process#GO:0010558;RNA destabilization#GO:0050779;regulation of protein metabolic process#GO:0051246;positive regulation of biological process#GO:0048518;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434;negative regulation of catabolic process#GO:0009895;regulation of protein catabolic process#GO:0042176;regulation of RNA metabolic process#GO:0051252;regulation of RNA stability#GO:0043487;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of proteasomal protein catabolic process#GO:1901799;negative regulation of protein metabolic process#GO:0051248;positive regulation of RNA metabolic process#GO:0051254;positive regulation of mRNA catabolic process#GO:0061014;regulation of biosynthetic process#GO:0009889;positive regulation of catabolic process#GO:0009896;regulation of protein modification process#GO:0031399;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;regulation of protein ubiquitination#GO:0031396;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522 membraneless organelle#GO:0043228;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;nuclear body#GO:0016604;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;nucleoplasm#GO:0005654;organelle#GO:0043226;cytoplasmic ribonucleoprotein granule#GO:0036464;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;PML body#GO:0016605;intracellular membrane-bounded organelle#GO:0043231 endoribonuclease#PC00094 HUMAN|HGNC=33194|UniProtKB=A6NJT0 A6NJT0 UNCX PTHR46799:SF1 HOMEOBOX PROTEIN UNC-4 HOMOLOG HOMEOBOX PROTEIN UNC-4 HOMOLOG nucleic acid binding#GO:0003676;binding#GO:0005488;double-stranded DNA binding#GO:0003690;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA binding#GO:0003677 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=28567|UniProtKB=Q8N1D5 Q8N1D5 CFAP107 PTHR31180:SF2 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 107-RELATED CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 107 supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;ciliary plasm#GO:0097014;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cytoskeleton#GO:0005856;organelle#GO:0043226;axonemal microtubule#GO:0005879;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cytoplasmic microtubule#GO:0005881;microtubule#GO:0005874;axoneme#GO:0005930;membrane-bounded organelle#GO:0043227;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;cilium#GO:0005929;intracellular organelle#GO:0043229 HUMAN|HGNC=25444|UniProtKB=Q8NCD3 Q8NCD3 HJURP PTHR15992:SF5 HOLLIDAY JUNCTION RECOGNITION PROTEIN HOLLIDAY JUNCTION RECOGNITION PROTEIN histone binding#GO:0042393;binding#GO:0005488;protein binding#GO:0005515 kinetochore assembly#GO:0051382;organelle assembly#GO:0070925;chromosome organization#GO:0051276;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;kinetochore organization#GO:0051383;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;chromatin organization#GO:0006325;cellular component assembly#GO:0022607 intracellular organelle#GO:0043229;chromosome, centromeric region#GO:0000775;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=28632|UniProtKB=Q8N988 Q8N988 ZNF557 PTHR24381:SF145 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 557 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=20589|UniProtKB=Q9P0J7 Q9P0J7 KCMF1 PTHR12268:SF13 E3 UBIQUITIN-PROTEIN LIGASE KCMF1 E3 UBIQUITIN-PROTEIN LIGASE KCMF1 transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659 primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511 cell periphery#GO:0071944;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=19857|UniProtKB=Q86U28 Q86U28 ISCA2 PTHR43011:SF1 IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL metal ion binding#GO:0046872;cation binding#GO:0043169;iron-sulfur cluster binding#GO:0051536;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;transition metal ion binding#GO:0046914;iron ion binding#GO:0005506 biosynthetic process#GO:0009058;iron-sulfur cluster assembly#GO:0016226;cellular component assembly#GO:0022607;gene expression#GO:0010467;protein maturation#GO:0051604;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;protein metabolic process#GO:0019538;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739 HUMAN|HGNC=22058|UniProtKB=Q8IV31 Q8IV31 TMEM139 PTHR36294:SF1 TRANSMEMBRANE PROTEIN 139 TRANSMEMBRANE PROTEIN 139 HUMAN|HGNC=23191|UniProtKB=Q8NA92 Q8NA92 THAP8 PTHR46927:SF2 AGAP005574-PA THAP DOMAIN-CONTAINING PROTEIN 8 HUMAN|HGNC=19620|UniProtKB=A6NND4 A6NND4 OR2AT4 PTHR48001:SF176 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2AT4 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 cell communication#GO:0007154;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=20148|UniProtKB=A6NEE1 A6NEE1 PLEKHD1 PTHR14383:SF1 SWAP-70 RECOMBINASE PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY D MEMBER 1 GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 intracellular signal transduction#GO:0035556;Rho protein signal transduction#GO:0007266;cell communication#GO:0007154;intracellular signaling cassette#GO:0141124;signaling#GO:0023052;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=37208|UniProtKB=A6NKL6 A6NKL6 TMEM200C PTHR31815:SF2 AGAP005329-PA TRANSMEMBRANE PROTEIN 200C HUMAN|HGNC=28533|UniProtKB=Q8N5S1 Q8N5S1 SLC25A41 PTHR24089:SF181 SOLUTE CARRIER FAMILY 25 MITOCHONDRIAL CARRIER PROTEIN SCAMC-3L antiporter activity#GO:0015297;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;purine nucleotide transmembrane transporter activity#GO:0015216;active transmembrane transporter activity#GO:0022804;phosphate transmembrane transporter activity#GO:0005315;organophosphate ester transmembrane transporter activity#GO:0015605;nucleobase-containing compound transmembrane transporter activity#GO:0015932;carbohydrate derivative transmembrane transporter activity#GO:1901505 transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810;organophosphate ester transport#GO:0015748;nucleobase-containing compound transport#GO:0015931;nitrogen compound transport#GO:0071705;carbohydrate derivative transport#GO:1901264;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739 mitochondrial carrier protein#PC00158;secondary carrier transporter#PC00258 HUMAN|HGNC=3655|UniProtKB=P16591 P16591 FER PTHR24418:SF227 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE FER phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein binding#GO:0005515;protein kinase activity#GO:0004672;signaling receptor binding#GO:0005102;binding#GO:0005488;non-membrane spanning protein tyrosine kinase activity#GO:0004715;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein tyrosine kinase activity#GO:0004713;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 cell adhesion#GO:0007155;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;chemotaxis#GO:0006935;regulation of immune response#GO:0050776;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;immune response-regulating signaling pathway#GO:0002764;signaling#GO:0023052;locomotion#GO:0040011;response to stimulus#GO:0050896;cell differentiation#GO:0030154;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;developmental process#GO:0032502;regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166;response to external stimulus#GO:0009605;cellular developmental process#GO:0048869;signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;taxis#GO:0042330;response to chemical#GO:0042221 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 non-receptor tyrosine protein kinase#PC00168 Cadherin signaling pathway#P00012>Fer#P00469 HUMAN|HGNC=23334|UniProtKB=Q5VT79 Q5VT79 ANXA8L1 PTHR10502:SF133 ANNEXIN ANNEXIN A8-RELATED ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;phospholipid binding#GO:0005543;binding#GO:0005488;lipid binding#GO:0008289;phosphatidylserine binding#GO:0001786 transport#GO:0006810;intracellular transport#GO:0046907;endosome organization#GO:0007032;vesicle organization#GO:0016050;endosomal transport#GO:0016197;cellular localization#GO:0051641;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;localization#GO:0051179;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;cellular component organization#GO:0016043;organelle organization#GO:0006996;endomembrane system organization#GO:0010256;vesicle-mediated transport#GO:0016192 membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;sarcolemma#GO:0042383;intracellular organelle#GO:0043229;plasma membrane#GO:0005886;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;cell periphery#GO:0071944;nucleus#GO:0005634;vesicle membrane#GO:0012506;membrane#GO:0016020 calcium-binding protein#PC00060 HUMAN|HGNC=20460|UniProtKB=Q8N5D6 Q8N5D6 GBGT1 PTHR10462:SF49 GLYCOSYLTRANSFERASE-RELATED GLOBOSIDE ALPHA-1,3-N-ACETYLGALACTOSAMINYLTRANSFERASE 1 glycosyltransferase activity#GO:0016757;acetylgalactosaminyltransferase activity#GO:0008376;UDP-glycosyltransferase activity#GO:0008194;catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758 vesicle#GO:0031982;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 glycosyltransferase#PC00111 HUMAN|HGNC=7819|UniProtKB=P55769 P55769 SNU13 PTHR23105:SF38 RIBOSOMAL PROTEIN L7AE FAMILY MEMBER NHP2-LIKE PROTEIN 1 binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;ribonucleoprotein complex biogenesis#GO:0022613;RNA splicing, via transesterification reactions#GO:0000375;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;mRNA processing#GO:0006397;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;biosynthetic process#GO:0009058;maturation of SSU-rRNA#GO:0030490;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;ribosomal small subunit biogenesis#GO:0042274;RNA splicing#GO:0008380;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170 organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;spliceosomal complex#GO:0005681;organelle lumen#GO:0043233;small-subunit processome#GO:0032040;spliceosomal snRNP complex#GO:0097525;sno(s)RNA-containing ribonucleoprotein complex#GO:0005732;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;precatalytic spliceosome#GO:0071011;nucleolus#GO:0005730;preribosome#GO:0030684;intracellular organelle#GO:0043229;spliceosomal tri-snRNP complex#GO:0097526;U4/U6 x U5 tri-snRNP complex#GO:0046540;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;small nuclear ribonucleoprotein complex#GO:0030532;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;Sm-like protein family complex#GO:0120114;membraneless organelle#GO:0043228 ribosomal protein#PC00202;translational protein#PC00263 HUMAN|HGNC=14259|UniProtKB=Q9ULW5 Q9ULW5 RAB26 PTHR47978:SF65 FAMILY NOT NAMED RAS-RELATED PROTEIN RAB-26 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;nucleoside phosphate binding#GO:1901265;guanyl nucleotide binding#GO:0019001;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;hydrolase activity, acting on acid anhydrides#GO:0016817;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;anion binding#GO:0043168;small molecule binding#GO:0036094;GTPase activity#GO:0003924;ion binding#GO:0043167;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleotide binding#GO:0000166 regulation of secretion#GO:0051046;regulation of transport#GO:0051049;regulation of localization#GO:0032879;regulation of exocytosis#GO:0017157;regulation of secretion by cell#GO:1903530;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789 Golgi apparatus#GO:0005794;endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular vesicle#GO:0097708;vesicle#GO:0031982;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 small GTPase#PC00208 HUMAN|HGNC=53925|UniProtKB=A0A096LNW5 A0A096LNW5 NOTCH2NLR PTHR12916:SF16 CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2 NOTCH HOMOLOG 2 N-TERMINAL-LIKE PROTEIN A-RELATED binding#GO:0005488;signaling receptor binding#GO:0005102;protein binding#GO:0005515 signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;Notch signaling pathway#GO:0007219;cell surface receptor signaling pathway#GO:0007166 oxidase#PC00175;oxidoreductase#PC00176 HUMAN|HGNC=17468|UniProtKB=Q96HC4 Q96HC4 PDLIM5 PTHR24214:SF32 PDZ AND LIM DOMAIN PROTEIN ZASP PDZ AND LIM DOMAIN PROTEIN 5 protein binding#GO:0005515;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779 actin filament-based process#GO:0030029;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;anatomical structure development#GO:0048856;cellular component organization#GO:0016043;circulatory system development#GO:0072359;muscle structure development#GO:0061061;actin cytoskeleton organization#GO:0030036;developmental process#GO:0032502;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;animal organ development#GO:0048513;cellular process#GO:0009987;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;heart development#GO:0007507;multicellular organismal process#GO:0032501 I band#GO:0031674;actin filament#GO:0005884;cytoskeleton#GO:0005856;stress fiber#GO:0001725;adherens junction#GO:0005912;cell junction#GO:0030054;sarcomere#GO:0030017;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;contractile muscle fiber#GO:0043292;Z disc#GO:0030018;actomyosin#GO:0042641;cell-cell junction#GO:0005911;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;myofibril#GO:0030016;actin filament bundle#GO:0032432;actin cytoskeleton#GO:0015629;organelle#GO:0043226;cellular anatomical structure#GO:0110165 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=25804|UniProtKB=Q8TBM7 Q8TBM7 TMEM254 PTHR34104:SF3 TRANSMEMBRANE PROTEIN 254 TRANSMEMBRANE PROTEIN 254 HUMAN|HGNC=3285|UniProtKB=P23588 P23588 EIF4B PTHR23236:SF42 EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H EUKARYOTIC TRANSLATION INITIATION FACTOR 4B RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 translation factor#PC00223;translation initiation factor#PC00224;translational protein#PC00263 HUMAN|HGNC=37228|UniProtKB=A6NI86 A6NI86 GOLGA6L10 PTHR23143:SF19 TRICHOHYALIN-RELATED GOLGIN A6 FAMILY LIKE 10-RELATED actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=3030|UniProtKB=P55039 P55039 DRG2 PTHR43127:SF2 DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2 DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2 ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;nucleotide binding#GO:0000166;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;guanyl nucleotide binding#GO:0019001;nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;binding#GO:0005488;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;cytoplasmic translation#GO:0002181;translation#GO:0006412;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=23815|UniProtKB=Q6ZU67 Q6ZU67 BEND4 PTHR35082:SF1 BEN DOMAIN-CONTAINING PROTEIN 4 BEN DOMAIN-CONTAINING PROTEIN 4 HUMAN|HGNC=3974|UniProtKB=O95954 O95954 FTCD PTHR12234:SF0 FORMIMINOTRANSFERASE-CYCLODEAMINASE FORMIMIDOYLTRANSFERASE-CYCLODEAMINASE transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;catalytic activity#GO:0003824;lyase activity#GO:0016829 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;intracellular organelle#GO:0043229;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794 HUMAN|HGNC=14477|UniProtKB=Q9H0U6 Q9H0U6 MRPL18 PTHR12899:SF23 39S RIBOSOMAL PROTEIN L18, MITOCHONDRIAL LARGE RIBOSOMAL SUBUNIT PROTEIN UL18M RNA binding#GO:0003723;rRNA binding#GO:0019843;binding#GO:0005488;nucleic acid binding#GO:0003676 transport#GO:0006810;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;nucleic acid transport#GO:0050657;localization#GO:0051179;cellular process#GO:0009987;nitrogen compound transport#GO:0071705;macromolecule localization#GO:0033036;establishment of RNA localization#GO:0051236;RNA transport#GO:0050658;RNA localization#GO:0006403;nucleobase-containing compound transport#GO:0015931 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 ribosomal protein#PC00202;translational protein#PC00263 HUMAN|HGNC=28449|UniProtKB=C9JLR9 C9JLR9 ZFTA PTHR34589:SF2 SIMILAR TO RIKEN CDNA 2700081O15 ZINC FINGER TRANSLOCATION-ASSOCIATED PROTEIN negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892 HUMAN|HGNC=23397|UniProtKB=Q5T1M5 Q5T1M5 FKBP15 PTHR44927:SF1 FK506-BINDING PROTEIN 15 FK506-BINDING PROTEIN 15 growth cone#GO:0030426;axon#GO:0030424;site of polarized growth#GO:0030427;neuron projection#GO:0043005;cellular anatomical structure#GO:0110165;distal axon#GO:0150034;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995 HUMAN|HGNC=20331|UniProtKB=Q14644 Q14644 RASA3 PTHR10194:SF53 RAS GTPASE-ACTIVATING PROTEINS RAS GTPASE-ACTIVATING PROTEIN 3 GTPase-activating protein#PC00257 HUMAN|HGNC=10933|UniProtKB=Q9NRA2 Q9NRA2 SLC17A5 PTHR11662:SF432 SOLUTE CARRIER FAMILY 17 SIALIN transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;carbohydrate derivative transmembrane transporter activity#GO:1901505 establishment of localization#GO:0051234;localization#GO:0051179;carboxylic acid transport#GO:0046942;organic acid transport#GO:0015849;transport#GO:0006810 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;apical plasma membrane#GO:0016324;lysosome#GO:0005764;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;apical part of cell#GO:0045177;lytic vacuole#GO:0000323;membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane region#GO:0098590;vacuole#GO:0005773;plasma membrane#GO:0005886;cytoplasm#GO:0005737 secondary carrier transporter#PC00258 HUMAN|HGNC=4130|UniProtKB=Q9NY28 Q9NY28 GALNT8 PTHR11675:SF50 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 8-RELATED hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;catalytic activity#GO:0003824;glycosyltransferase activity#GO:0016757;acetylgalactosaminyltransferase activity#GO:0008376;catalytic activity, acting on a protein#GO:0140096;UDP-glycosyltransferase activity#GO:0008194;polypeptide N-acetylgalactosaminyltransferase activity#GO:0004653 biosynthetic process#GO:0009058;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;protein O-linked glycosylation#GO:0006493;cellular process#GO:0009987;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 transferase#PC00220;glycosyltransferase#PC00111 HUMAN|HGNC=9032|UniProtKB=Q5R387 Q5R387 PLA2G2C PTHR11716:SF5 PHOSPHOLIPASE A2 FAMILY MEMBER INACTIVE GROUP IIC SECRETORY PHOSPHOLIPASE A2-RELATED hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;phospholipid binding#GO:0005543;carboxylic ester hydrolase activity#GO:0052689;lipase activity#GO:0016298;small molecule binding#GO:0036094;signaling receptor binding#GO:0005102;ion binding#GO:0043167;cation binding#GO:0043169;hydrolase activity#GO:0016787;phospholipase activity#GO:0120569;glycerophospholipase activity#GO:0004620;A2-type glycerophospholipase activity#GO:0004623;calcium ion binding#GO:0005509;binding#GO:0005488;lipid binding#GO:0008289;metal ion binding#GO:0046872;protein binding#GO:0005515 glycerolipid metabolic process#GO:0046486;phosphatidylglycerol metabolic process#GO:0046471;glycerophospholipid metabolic process#GO:0006650;phosphatidylcholine metabolic process#GO:0046470;phospholipid metabolic process#GO:0006644;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;metabolic process#GO:0008152;lipid metabolic process#GO:0006629 phospholipase#PC00186 HUMAN|HGNC=29990|UniProtKB=O60356 O60356 NUPR1 PTHR17149:SF5 NUCLEAR PROTEIN 1 AND 2 NUCLEAR PROTEIN 1 regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of cell population proliferation#GO:0008285;regulation of cell cycle#GO:0051726;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;negative regulation of cellular process#GO:0048523;regulation of cell population proliferation#GO:0042127;negative regulation of cell cycle#GO:0045786 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=23401|UniProtKB=Q9Y6A9 Q9Y6A9 SPCS1 PTHR13202:SF0 MICROSOMAL SIGNAL PEPTIDASE 12 KDA SUBUNIT SIGNAL PEPTIDASE COMPLEX SUBUNIT 1 protein targeting#GO:0006605;primary metabolic process#GO:0044238;localization#GO:0051179;protein metabolic process#GO:0019538;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;establishment of protein localization to endoplasmic reticulum#GO:0072599;establishment of protein localization#GO:0045184;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;establishment of protein localization to organelle#GO:0072594;macromolecule metabolic process#GO:0043170;establishment of localization#GO:0051234;protein targeting to ER#GO:0045047;metabolic process#GO:0008152 membrane protein complex#GO:0098796;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;peptidase complex#GO:1905368;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endopeptidase complex#GO:1905369;organelle membrane#GO:0031090;endoplasmic reticulum protein-containing complex#GO:0140534 protein modifying enzyme#PC00260;protease#PC00190 Vasopressin synthesis#P04395>Signal Peptidase#P04589 HUMAN|HGNC=19180|UniProtKB=Q7L0R7 Q7L0R7 RNF44 PTHR46171:SF2 GH10160P RING FINGER PROTEIN 44 acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;primary metabolic process#GO:0044238;protein modification process#GO:0036211;cellular process#GO:0009987;protein modification by small protein conjugation#GO:0032446;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152 HUMAN|HGNC=31948|UniProtKB=Q2WEN9 Q2WEN9 CEACAM16 PTHR44427:SF10 CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 19 CELL ADHESION MOLECULE CEACAM16 nervous system process#GO:0050877;sensory perception#GO:0007600;sensory perception of mechanical stimulus#GO:0050954;system process#GO:0003008;multicellular organismal process#GO:0032501;sensory perception of sound#GO:0007605 cell adhesion molecule#PC00069 HUMAN|HGNC=9508|UniProtKB=P49768 P49768 PSEN1 PTHR10202:SF18 PRESENILIN PRESENILIN-1 catalytic activity#GO:0003824;aspartic-type endopeptidase activity#GO:0004190;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175 macromolecule metabolic process#GO:0043170;Notch signaling pathway#GO:0007219;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;cell surface receptor signaling pathway#GO:0007166;metabolic process#GO:0008152;biological regulation#GO:0065007;biosynthetic process#GO:0009058;membrane protein ectodomain proteolysis#GO:0006509;protein maturation#GO:0051604;gene expression#GO:0010467;membrane protein proteolysis#GO:0033619;signal transduction#GO:0007165;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein processing#GO:0016485;monoatomic ion homeostasis#GO:0050801;cell communication#GO:0007154;protein metabolic process#GO:0019538;inorganic ion homeostasis#GO:0098771;proteolysis#GO:0006508;calcium ion homeostasis#GO:0055074;signaling#GO:0023052;homeostatic process#GO:0042592;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238 plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;membrane#GO:0016020;catalytic complex#GO:1902494 aspartic protease#PC00053;protease#PC00190 Alzheimer disease-amyloid secretase pathway#P00003>Presenilin#P00098;Alzheimer disease-presenilin pathway#P00004>Presenilin N-terminal fragment#P00140;Alzheimer disease-amyloid secretase pathway#P00003>Presenilin C-terminal fragment#P00102;Alzheimer disease-amyloid secretase pathway#P00003>Presenilin N-terminal fragment#P00088;Alzheimer disease-presenilin pathway#P00004>Presenilin C-terminal fragment#P00155;Notch signaling pathway#P00045>Presenilin#P01110;Alzheimer disease-presenilin pathway#P00004>Presenilin#P00129 HUMAN|HGNC=25440|UniProtKB=Q8N394 Q8N394 TMTC2 PTHR44216:SF3 PROTEIN O-MANNOSYL-TRANSFERASE TMTC2 PROTEIN O-MANNOSYL-TRANSFERASE TMTC2 protein modifying enzyme#PC00260 HUMAN|HGNC=24511|UniProtKB=Q9Y3Y2 Q9Y3Y2 CHTOP PTHR48426:SF1 CHROMATIN TARGET OF PRMT1 PROTEIN CHROMATIN TARGET OF PRMT1 PROTEIN nucleic acid binding#GO:0003676;binding#GO:0005488;small molecule binding#GO:0036094;nucleoside phosphate binding#GO:1901265;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;nucleotide binding#GO:0000166;heterocyclic compound binding#GO:1901363 cellular component organization or biogenesis#GO:0071840;chromatin remodeling#GO:0006338;chromatin organization#GO:0006325;cellular component organization#GO:0016043;cellular process#GO:0009987 HUMAN|HGNC=20458|UniProtKB=Q8WXF5 Q8WXF5 CRYGN PTHR11818:SF22 BETA/GAMMA CRYSTALLIN GAMMA-CRYSTALLIN N structural molecule activity#GO:0005198 sensory perception of light stimulus#GO:0050953;visual perception#GO:0007601;visual system development#GO:0150063;animal gross anatomical part developmental process#GO:0160108;camera-type eye development#GO:0043010;nervous system process#GO:0050877;sensory perception#GO:0007600;anatomical structure development#GO:0048856;eye development#GO:0001654;system development#GO:0048731;sensory system development#GO:0048880;multicellular organismal process#GO:0032501;sensory organ development#GO:0007423;developmental process#GO:0032502;lens development in camera-type eye#GO:0002088;animal organ development#GO:0048513;multicellular organism development#GO:0007275;system process#GO:0003008 structural protein#PC00211 HUMAN|HGNC=12473|UniProtKB=P63146 P63146 UBE2B PTHR24067:SF246 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2 B ubiquitin-like protein conjugating enzyme activity#GO:0061650;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;ubiquitin conjugating enzyme activity#GO:0061631;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740 modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;protein modification by small protein conjugation or removal#GO:0070647;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;cellular response to stimulus#GO:0051716;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;protein polyubiquitination#GO:0000209;protein modification process#GO:0036211;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;catabolic process#GO:0009056;response to stimulus#GO:0050896;DNA damage response#GO:0006974;macromolecule catabolic process#GO:0009057;DNA metabolic process#GO:0006259;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;DNA repair#GO:0006281;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;response to stress#GO:0006950;proteasomal protein catabolic process#GO:0010498;post-translational protein modification#GO:0043687;nucleobase-containing compound metabolic process#GO:0006139;protein ubiquitination#GO:0016567 chromatin#GO:0000785;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;ubiquitin ligase complex#GO:0000151;membraneless organelle#GO:0043228 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 Ubiquitin proteasome pathway#P00060>E2#P01491 HUMAN|HGNC=29260|UniProtKB=Q6PIU2 Q6PIU2 NCEH1 PTHR23024:SF108 ARYLACETAMIDE DEACETYLASE NEUTRAL CHOLESTEROL ESTER HYDROLASE 1 serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;catalytic activity#GO:0003824 cellular anatomical structure#GO:0110165;membrane#GO:0016020 deacetylase#PC00087 HUMAN|HGNC=2747|UniProtKB=P26196 P26196 DDX6 PTHR47960:SF2 DEAD-BOX ATP-DEPENDENT RNA HELICASE 50 ATP-DEPENDENT RNA HELICASE DDX6-RELATED mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;cellular component assembly#GO:0022607;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of macromolecule biosynthetic process#GO:0010556;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of translation#GO:0006417;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;organelle assembly#GO:0070925;negative regulation of translation#GO:0017148;cytoplasmic stress granule assembly#GO:0034063;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of protein metabolic process#GO:0051248;negative regulation of metabolic process#GO:0009892;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;negative regulation of biological process#GO:0048519;P-body assembly#GO:0033962;regulation of biological process#GO:0050789 cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;organelle#GO:0043226;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;P-body#GO:0000932;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoplasmic stress granule#GO:0010494 RNA helicase#PC00032;RNA metabolism protein#PC00031 HUMAN|HGNC=17757|UniProtKB=Q9H2S6 Q9H2S6 TNMD PTHR14064:SF3 CHONDROMODULIN-RELATED TENOMODULIN regulation of biological process#GO:0050789;regulation of multicellular organismal development#GO:2000026;negative regulation of multicellular organismal process#GO:0051241;negative regulation of biological process#GO:0048519;negative regulation of cell population proliferation#GO:0008285;biological regulation#GO:0065007;regulation of developmental process#GO:0050793;regulation of multicellular organismal process#GO:0051239;regulation of cellular process#GO:0050794;regulation of vasculature development#GO:1901342;negative regulation of cellular process#GO:0048523;regulation of angiogenesis#GO:0045765;regulation of cell population proliferation#GO:0042127;negative regulation of angiogenesis#GO:0016525;regulation of anatomical structure morphogenesis#GO:0022603 HUMAN|HGNC=9106|UniProtKB=O60486 O60486 PLXNC1 PTHR22625:SF4 PLEXIN PLEXIN-C1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 regulation of axonogenesis#GO:0050770;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;regulation of anatomical structure morphogenesis#GO:0022603;positive regulation of cell differentiation#GO:0045597;cell surface receptor signaling pathway#GO:0007166;positive regulation of cell development#GO:0010720;nervous system development#GO:0007399;regulation of multicellular organismal process#GO:0051239;cellular component assembly#GO:0022607;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;regulation of neuron projection development#GO:0010975;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;positive regulation of axonogenesis#GO:0050772;regulation of biological quality#GO:0065008;positive regulation of cellular component organization#GO:0051130;animal gross anatomical part developmental process#GO:0160108;signaling#GO:0023052;positive regulation of nervous system development#GO:0051962;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;synapse assembly#GO:0007416;regulation of biological process#GO:0050789;regulation of multicellular organismal development#GO:2000026;positive regulation of multicellular organismal process#GO:0051240;regulation of cell shape#GO:0008360;cell junction assembly#GO:0034329;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of cell migration#GO:0030334;positive regulation of developmental process#GO:0051094;developmental process#GO:0032502;regulation of cell differentiation#GO:0045595;regulation of cell projection organization#GO:0031344;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;negative regulation of cell adhesion#GO:0007162;multicellular organismal process#GO:0032501;regulation of cell adhesion#GO:0030155;positive regulation of cellular process#GO:0048522;regulation of cell development#GO:0060284;system development#GO:0048731;regulation of cell motility#GO:2000145;cell communication#GO:0007154;anatomical structure development#GO:0048856;regulation of nervous system development#GO:0051960;synapse organization#GO:0050808;positive regulation of cell projection organization#GO:0031346;regulation of developmental process#GO:0050793;positive regulation of neurogenesis#GO:0050769;regulation of cellular process#GO:0050794;cell junction organization#GO:0034330;cellular response to stimulus#GO:0051716;regulation of neurogenesis#GO:0050767 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;signaling receptor complex#GO:0043235;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=28756|UniProtKB=Q96GS6 Q96GS6 ABHD17A PTHR12277:SF202 ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN ALPHA_BETA HYDROLASE DOMAIN-CONTAINING PROTEIN 17A catalytic activity, acting on a protein#GO:0140096;palmitoyl hydrolase activity#GO:0098599;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;thiolester hydrolase activity#GO:0016790 regulation of synapse structure or activity#GO:0050803;regulation of protein localization#GO:0032880;regulation of localization#GO:0032879;regulation of biological quality#GO:0065008;regulation of synapse organization#GO:0050807;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;positive regulation of biological process#GO:0048518;regulation of postsynapse organization#GO:0099175 vesicle membrane#GO:0012506;membrane#GO:0016020;cell periphery#GO:0071944;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;plasma membrane#GO:0005886;cytoplasm#GO:0005737;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;endosome#GO:0005768;endosome membrane#GO:0010008;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622 serine protease#PC00203 HUMAN|HGNC=24065|UniProtKB=Q9UH62 Q9UH62 ARMCX3 PTHR15712:SF8 ARMADILLO REPEAT CONTAINING PROTEIN ARMADILLO REPEAT-CONTAINING X-LINKED PROTEIN 3 organelle localization#GO:0051640;axonal transport#GO:0098930;microtubule-based transport#GO:0099111;cellular localization#GO:0051641;localization#GO:0051179;microtubule-based movement#GO:0007018;establishment of organelle localization#GO:0051656;intracellular transport#GO:0046907;transport#GO:0006810;transport along microtubule#GO:0010970;establishment of localization#GO:0051234;mitochondrion localization#GO:0051646;microtubule-based process#GO:0007017;axo-dendritic transport#GO:0008088;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;cytoskeleton-dependent intracellular transport#GO:0030705;organelle transport along microtubule#GO:0072384 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 scaffold/adaptor protein#PC00226 HUMAN|HGNC=14624|UniProtKB=Q99618 Q99618 CDCA3 PTHR34756:SF1 CELL DIVISION CYCLE-ASSOCIATED PROTEIN 3 CELL DIVISION CYCLE-ASSOCIATED PROTEIN 3 HUMAN|HGNC=23295|UniProtKB=Q9BQ13 Q9BQ13 KCTD14 PTHR14499:SF3 POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD14 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 scaffold/adaptor protein#PC00226 HUMAN|HGNC=25784|UniProtKB=Q5H9S7 Q5H9S7 DCAF17 PTHR14815:SF2 DDB1- AND CUL4-ASSOCIATED FACTOR 17 DDB1- AND CUL4-ASSOCIATED FACTOR 17 catalytic complex#GO:1902494;transferase complex#GO:1990234;Cul4-RING E3 ubiquitin ligase complex#GO:0080008;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991 HUMAN|HGNC=24549|UniProtKB=Q9Y605 Q9Y605 MRFAP1 PTHR31324:SF1 MORF4 FAMILY-ASSOCIATED PROTEIN 1-RELATED MORF4 FAMILY-ASSOCIATED PROTEIN 1 HUMAN|HGNC=24504|UniProtKB=Q63HN1 Q63HN1 SPATA31F2P PTHR21859:SF15 ACROSOME-SPECIFIC PROTEIN PROTEIN SPATA31F1-RELATED HUMAN|HGNC=8583|UniProtKB=P05121 P05121 SERPINE1 PTHR11461:SF49 SERINE PROTEASE INHIBITOR, SERPIN PLASMINOGEN ACTIVATOR INHIBITOR 1 enzyme inhibitor activity#GO:0004857;molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866;peptidase regulator activity#GO:0061134;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;molecular function inhibitor activity#GO:0140678;serine-type endopeptidase inhibitor activity#GO:0004867;enzyme regulator activity#GO:0030234 negative regulation of multicellular organismal process#GO:0051241;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of protein metabolic process#GO:0051248;regulation of developmental process#GO:0050793;regulation of angiogenesis#GO:0045765;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of wound healing#GO:0061045;regulation of primary metabolic process#GO:0080090;regulation of hemostasis#GO:1900046;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of response to stimulus#GO:0048585;regulation of coagulation#GO:0050818;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of vasculature development#GO:1901342;regulation of response to stress#GO:0080134;negative regulation of blood coagulation#GO:0030195;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;negative regulation of angiogenesis#GO:0016525;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;positive regulation of multicellular organismal process#GO:0051240;regulation of multicellular organismal development#GO:2000026;regulation of biological process#GO:0050789;regulation of body fluid levels#GO:0050878;regulation of blood coagulation#GO:0030193;regulation of wound healing#GO:0061041;negative regulation of metabolic process#GO:0009892;positive regulation of coagulation#GO:0050820;negative regulation of hemostasis#GO:1900047;negative regulation of coagulation#GO:0050819;regulation of biological quality#GO:0065008;regulation of protein metabolic process#GO:0051246;regulation of response to wounding#GO:1903034;negative regulation of macromolecule biosynthetic process#GO:0010558;positive regulation of biological process#GO:0048518;regulation of response to external stimulus#GO:0032101;regulation of multicellular organismal process#GO:0051239;negative regulation of response to external stimulus#GO:0032102;regulation of proteolysis#GO:0030162;negative regulation of response to wounding#GO:1903035;regulation of anatomical structure morphogenesis#GO:0022603 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 Blood coagulation#P00011>PAI-1#P00411;p53 pathway#P00059>PAI#G04700;Plasminogen activating cascade#P00050>PAI-1#P01245;CCKR signaling map#P06959>PAI1#G07281;CCKR signaling map#P06959>PAI1#G06987 HUMAN|HGNC=24870|UniProtKB=Q68CQ7 Q68CQ7 GLT8D1 PTHR13778:SF3 GLYCOSYLTRANSFERASE 8 DOMAIN-CONTAINING PROTEIN GLYCOSYLTRANSFERASE 8 DOMAIN-CONTAINING PROTEIN 1 glycosyltransferase activity#GO:0016757;glucosyltransferase activity#GO:0046527;catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 glycosyltransferase#PC00111;transferase#PC00220 HUMAN|HGNC=16191|UniProtKB=Q8IVV8 Q8IVV8 NKAIN4 PTHR13084:SF5 T-CELL LYMPHOMA BREAKPOINT-ASSOCIATED TARGET 1-RELATED SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA-1-INTERACTING PROTEIN 4 regulation of monoatomic ion transport#GO:0043269;regulation of metal ion transport#GO:0010959;regulation of transport#GO:0051049;regulation of localization#GO:0032879;biological regulation#GO:0065007;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;membrane#GO:0016020 HUMAN|HGNC=8510|UniProtKB=Q92882 Q92882 OSTF1 PTHR24155:SF10 OSTEOCLAST-STIMULATING FACTOR 1 OSTEOCLAST-STIMULATING FACTOR 1 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154 HUMAN|HGNC=20521|UniProtKB=P60372 P60372 KRTAP10-4 PTHR23262:SF243 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 10-4 structural protein#PC00211 HUMAN|HGNC=28491|UniProtKB=Q5SY80 Q5SY80 CATSPERE PTHR33722:SF3 CATION CHANNEL SPERM-ASSOCIATED PROTEIN SUBUNIT DELTA-RELATED CATION CHANNEL SPERM-ASSOCIATED AUXILIARY SUBUNIT EPSILON developmental process involved in reproduction#GO:0003006;germ cell development#GO:0007281;sperm motility#GO:0097722;anatomical structure maturation#GO:0071695;gamete generation#GO:0007276;microtubule-based movement#GO:0007018;cell motility#GO:0048870;cell differentiation#GO:0030154;cellular process involved in reproduction in multicellular organism#GO:0022412;reproductive process#GO:0022414;cell development#GO:0048468;spermatid differentiation#GO:0048515;spermatid development#GO:0007286;cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;sexual reproduction#GO:0019953;anatomical structure development#GO:0048856;cilium-dependent cell motility#GO:0060285;multicellular organismal reproductive process#GO:0048609;cilium movement involved in cell motility#GO:0060294;cellular process#GO:0009987;male gamete generation#GO:0048232;developmental maturation#GO:0021700;sperm capacitation#GO:0048240;flagellated sperm motility#GO:0030317;developmental process#GO:0032502;spermatogenesis#GO:0007283;cellular developmental process#GO:0048869;cell maturation#GO:0048469;microtubule-based process#GO:0007017 voltage-gated calcium channel complex#GO:0005891;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;sperm principal piece#GO:0097228;calcium channel complex#GO:0034704;cellular anatomical structure#GO:0110165;organelle#GO:0043226;motile cilium#GO:0031514;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cilium#GO:0005929;9+2 motile cilium#GO:0097729;transmembrane transporter complex#GO:1902495;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;cell periphery#GO:0071944;monoatomic ion channel complex#GO:0034702;CatSper complex#GO:0036128;sperm flagellum#GO:0036126;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;cation channel complex#GO:0034703;transporter complex#GO:1990351 voltage-gated ion channel#PC00241;transporter#PC00227 HUMAN|HGNC=15217|UniProtKB=Q6IFG1 Q6IFG1 OR52E8 PTHR26450:SF170 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 52E8 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=4581|UniProtKB=Q13003 Q13003 GRIK3 PTHR18966:SF174 IONOTROPIC GLUTAMATE RECEPTOR GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 3 metal ion transmembrane transporter activity#GO:0046873;signaling receptor activity#GO:0038023;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;transporter activity#GO:0005215;neurotransmitter receptor activity#GO:0030594;amino acid transmembrane transporter activity#GO:0015171;monoatomic cation transmembrane transporter activity#GO:0008324;gated channel activity#GO:0022836;transmembrane signaling receptor activity#GO:0004888;sodium ion transmembrane transporter activity#GO:0015081;monoatomic cation channel activity#GO:0005261;dicarboxylic acid transmembrane transporter activity#GO:0005310;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;sodium channel activity#GO:0005272;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;glutamate receptor activity#GO:0008066;channel activity#GO:0015267;molecular transducer activity#GO:0060089;potassium ion transmembrane transporter activity#GO:0015079;ligand-gated monoatomic ion channel activity#GO:0015276;potassium channel activity#GO:0005267;carboxylic acid transmembrane transporter activity#GO:0046943 chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;signaling#GO:0023052;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;trans-synaptic signaling#GO:0099537;regulation of signaling#GO:0023051;cell communication#GO:0007154;synaptic signaling#GO:0099536;cellular process#GO:0009987;regulation of trans-synaptic signaling#GO:0099177;synaptic transmission, glutamatergic#GO:0035249;cell-cell signaling#GO:0007267;biological regulation#GO:0065007 cell junction#GO:0030054;transporter complex#GO:1990351;cation channel complex#GO:0034703;signaling receptor complex#GO:0043235;synaptic membrane#GO:0097060;plasma membrane region#GO:0098590;postsynaptic specialization#GO:0099572;monoatomic ion channel complex#GO:0034702;neuron to neuron synapse#GO:0098984;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;presynaptic membrane#GO:0042734;membrane#GO:0016020;presynapse#GO:0098793;cell periphery#GO:0071944;transmembrane transporter complex#GO:1902495;sodium channel complex#GO:0034706;postsynaptic density membrane#GO:0098839;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;postsynaptic density#GO:0014069;asymmetric synapse#GO:0032279;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;membrane protein complex#GO:0098796;postsynapse#GO:0098794;plasma membrane protein complex#GO:0098797 transmembrane signal receptor#PC00197 Ionotropic glutamate receptor pathway#P00037>KA3#P01002;Huntington disease#P00029>Kainate receptor#P00796;Metabotropic glutamate receptor group III pathway#P00039>A/K#P01046;Ionotropic glutamate receptor pathway#P00037>A/K#P01025;Ionotropic glutamate receptor pathway#P00037>KA#P01026 HUMAN|HGNC=1958|UniProtKB=P43681 P43681 CHRNA4 PTHR18945:SF401 NEUROTRANSMITTER GATED ION CHANNEL NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4 acetylcholine receptor activity#GO:0015464;postsynaptic neurotransmitter receptor activity#GO:0098960;transmembrane signaling receptor activity#GO:0004888;gated channel activity#GO:0022836;monoatomic cation transmembrane transporter activity#GO:0008324;neurotransmitter receptor activity#GO:0030594;transporter activity#GO:0005215;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;signaling receptor activity#GO:0038023;ligand-gated monoatomic ion channel activity#GO:0015276;molecular transducer activity#GO:0060089;channel activity#GO:0015267;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315 regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;response to oxygen-containing compound#GO:1901700;regulation of signaling#GO:0023051;cellular response to chemical stimulus#GO:0070887;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;calcium ion transport#GO:0006816;regulation of membrane potential#GO:0042391;neuromuscular synaptic transmission#GO:0007274;response to chemical#GO:0042221;regulation of trans-synaptic signaling#GO:0099177;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;cellular process#GO:0009987;synaptic signaling#GO:0099536;response to nitrogen compound#GO:1901698;cell communication#GO:0007154;monoatomic cation transport#GO:0006812;localization#GO:0051179;trans-synaptic signaling#GO:0099537;membrane depolarization#GO:0051899;metal ion transport#GO:0030001;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;chemical synaptic transmission#GO:0007268;establishment of localization#GO:0051234;transport#GO:0006810;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;synaptic transmission, cholinergic#GO:0007271;cellular response to nitrogen compound#GO:1901699;acetylcholine receptor signaling pathway#GO:0095500 transporter complex#GO:1990351;cell junction#GO:0030054;synaptic membrane#GO:0097060;signaling receptor complex#GO:0043235;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;plasma membrane region#GO:0098590;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;transmembrane transporter complex#GO:1902495;postsynaptic membrane#GO:0045211;cellular anatomical structure#GO:0110165;synapse#GO:0045202;postsynapse#GO:0098794;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797 ligand-gated ion channel#PC00141 Nicotine pharmacodynamics pathway#P06587>CHRNA4#P06594;Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086;Nicotinic acetylcholine receptor signaling pathway#P00044>alpha#P01088 HUMAN|HGNC=23148|UniProtKB=Q9NUJ7 Q9NUJ7 PLCXD1 PTHR13593:SF24 FAMILY NOT NAMED PI-PLC X DOMAIN-CONTAINING PROTEIN 1 hydrolase activity#GO:0016787;phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 HUMAN|HGNC=21198|UniProtKB=Q9NWW0 Q9NWW0 HCFC1R1 PTHR16246:SF2 HOST CELL FACTOR C1 REGULATOR 1 HOST CELL FACTOR C1 REGULATOR 1 HUMAN|HGNC=49602|UniProtKB=A0A0C4DH43 A0A0C4DH43 IGHV2-70D PTHR23266:SF389 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 2-70-RELATED binding#GO:0005488;antigen binding#GO:0003823 lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;immune system process#GO:0002376;immune effector process#GO:0002252;response to stimulus#GO:0050896;adaptive immune response#GO:0002250;immune response#GO:0006955 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=31979|UniProtKB=Q5SQ80 Q5SQ80 ANKRD20A2P PTHR24147:SF1 ANKYRIN REPEAT DOMAIN 36-RELATED ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 20A1-RELATED HUMAN|HGNC=15245|UniProtKB=Q8NGI3 Q8NGI3 OR56B1 PTHR26450:SF69 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 56B1 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=18595|UniProtKB=Q96JB3 Q96JB3 HIC2 PTHR24399:SF27 ZINC FINGER AND BTB DOMAIN-CONTAINING HYPERMETHYLATED IN CANCER 2 PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;DNA-binding transcription repressor activity#GO:0001217;transcription regulatory region nucleic acid binding#GO:0001067 negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cytokine production#GO:0001817;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of multicellular organismal process#GO:0051239;negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218 HUMAN|HGNC=23496|UniProtKB=Q7Z2D5 Q7Z2D5 PLPPR4 PTHR10165:SF13 LIPID PHOSPHATE PHOSPHATASE PHOSPHOLIPID PHOSPHATASE-RELATED PROTEIN TYPE 4 hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 developmental process#GO:0032502;lipid metabolic process#GO:0006629;neuron projection morphogenesis#GO:0048812;lipid modification#GO:0030258;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;organophosphate metabolic process#GO:0019637;axon development#GO:0061564;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;cell communication#GO:0007154;dephosphorylation#GO:0016311;anatomical structure development#GO:0048856;system development#GO:0048731;primary metabolic process#GO:0044238;phospholipid dephosphorylation#GO:0046839;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;phospholipid metabolic process#GO:0006644;metabolic process#GO:0008152;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cell projection morphogenesis#GO:0048858;neuron projection development#GO:0031175;signal transduction#GO:0007165;cellular process#GO:0009987;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;neuron development#GO:0048666;axonogenesis#GO:0007409;phosphorus metabolic process#GO:0006793;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;phosphate-containing compound metabolic process#GO:0006796;cell differentiation#GO:0030154;cell projection organization#GO:0030030;response to stimulus#GO:0050896;cell morphogenesis#GO:0000902;signaling#GO:0023052;cell development#GO:0048468 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 phosphatase#PC00181;hydrolase#PC00121 HUMAN|HGNC=19|UniProtKB=Q16613 Q16613 AANAT PTHR10908:SF7 SEROTONIN N-ACETYLTRANSFERASE SEROTONIN N-ACETYLTRANSFERASE acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;acetyltransferase activity#GO:0016407;transferase activity#GO:0016740;N-acetyltransferase activity#GO:0008080;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 response to light stimulus#GO:0009416;response to stimulus#GO:0050896;circadian rhythm#GO:0007623;response to abiotic stimulus#GO:0009628;response to radiation#GO:0009314;photoperiodism#GO:0009648;rhythmic process#GO:0048511 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 acetyltransferase#PC00038;transferase#PC00220 HUMAN|HGNC=4218|UniProtKB=Q9NR23 Q9NR23 GDF3 PTHR11848:SF38 TGF-BETA FAMILY GROWTH_DIFFERENTIATION FACTOR 3 cytokine activity#GO:0005125;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772 signaling#GO:0023052;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;response to growth factor#GO:0070848;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;BMP signaling pathway#GO:0030509;response to endogenous stimulus#GO:0009719;cellular response to growth factor stimulus#GO:0071363;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;biological regulation#GO:0065007;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to BMP stimulus#GO:0071773;response to BMP#GO:0071772;cell surface receptor signaling pathway#GO:0007166;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 growth factor#PC00112 TGF-beta signaling pathway#P00052>TGFbeta#P01286 HUMAN|HGNC=18239|UniProtKB=Q68EM7 Q68EM7 ARHGAP17 PTHR14130:SF3 3BP-1 RELATED RHOGAP RHO GTPASE-ACTIVATING PROTEIN 17 enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234 regulation of small GTPase mediated signal transduction#GO:0051056;negative regulation of cellular process#GO:0048523;regulation of actin filament-based process#GO:0032970;regulation of response to stimulus#GO:0048583;negative regulation of response to stimulus#GO:0048585;regulation of actin cytoskeleton organization#GO:0032956;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;regulation of cell communication#GO:0010646;negative regulation of biological process#GO:0048519;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 GTPase-activating protein#PC00257 HUMAN|HGNC=49|UniProtKB=Q9NUT2 Q9NUT2 ABCB8 PTHR24221:SF662 ATP-BINDING CASSETTE SUB-FAMILY B MITOCHONDRIAL POTASSIUM CHANNEL ATP-BINDING SUBUNIT transmembrane transporter activity#GO:0022857;ATP-dependent activity#GO:0140657;transporter activity#GO:0005215;ATPase-coupled transmembrane transporter activity#GO:0042626;primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;cellular process#GO:0009987;transport#GO:0006810 membrane#GO:0016020;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 ATP-binding cassette (ABC) transporter#PC00003 HUMAN|HGNC=15880|UniProtKB=Q96SZ6 Q96SZ6 CDK5RAP1 PTHR43020:SF2 CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 1 MITOCHONDRIAL TRNA METHYLTHIOTRANSFERASE CDK5RAP1 binding#GO:0005488;small molecule binding#GO:0036094;transferase activity, transferring sulphur-containing groups#GO:0016782;catalytic activity, acting on a tRNA#GO:0140101;iron-sulfur cluster binding#GO:0051536;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on RNA#GO:0140098 RNA biosynthetic process#GO:0032774;tRNA modification#GO:0006400;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mitochondrial gene expression#GO:0140053;mitochondrial RNA metabolic process#GO:0000959;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;mitochondrial RNA modification#GO:1900864;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467;mitochondrial RNA processing#GO:0000963;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399 mitochondrion#GO:0005739;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=33877|UniProtKB=B1AL88 B1AL88 NALF1 PTHR15819:SF9 TRANSMEMBRANE PROTEIN FAM155 NALCN CHANNEL AUXILIARY FACTOR 1 transporter regulator activity#GO:0141108;molecular function regulator activity#GO:0098772;channel regulator activity#GO:0016247 cellular process#GO:0009987;import across plasma membrane#GO:0098739;inorganic ion import across plasma membrane#GO:0099587;transport#GO:0006810;import into cell#GO:0098657;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;inorganic cation import across plasma membrane#GO:0098659 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 HUMAN|HGNC=21056|UniProtKB=Q5T6L9 Q5T6L9 ERMARD PTHR31701:SF2 ENDOPLASMIC RETICULUM MEMBRANE-ASSOCIATED RNA DEGRADATION PROTEIN ENDOPLASMIC RETICULUM MEMBRANE-ASSOCIATED RNA DEGRADATION PROTEIN system development#GO:0048731;neurogenesis#GO:0022008;neuron migration#GO:0001764;multicellular organism development#GO:0007275;anatomical structure development#GO:0048856;cellular developmental process#GO:0048869;generation of neurons#GO:0048699;developmental process#GO:0032502;animal gross anatomical part developmental process#GO:0160108;nervous system development#GO:0007399;cell differentiation#GO:0030154;cell migration#GO:0016477;multicellular organismal process#GO:0032501;cell motility#GO:0048870;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229 HUMAN|HGNC=4311|UniProtKB=P48506 P48506 GCLC PTHR11164:SF0 GLUTAMATE CYSTEINE LIGASE GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT catalytic activity#GO:0003824;ligase activity#GO:0016874;ligase activity, forming carbon-nitrogen bonds#GO:0016879 biosynthetic process#GO:0009058;peptide metabolic process#GO:0006518;cellular process#GO:0009987;glutathione metabolic process#GO:0006749;sulfur compound metabolic process#GO:0006790;modified amino acid metabolic process#GO:0006575;metabolic process#GO:0008152 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494 ligase#PC00142;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=16813|UniProtKB=Q86WC6 Q86WC6 PPP1R27 PTHR46899:SF4 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 27 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 27 protein binding#GO:0005515;binding#GO:0005488;phosphatase binding#GO:0019902;enzyme binding#GO:0019899 phosphatase modulator#PC00184 HUMAN|HGNC=9044|UniProtKB=Q9HBJ0 Q9HBJ0 PLAC1 PTHR14380:SF2 PLACENTA-SPECIFIC PROTEIN 1 PLACENTA-SPECIFIC PROTEIN 1 HUMAN|HGNC=28409|UniProtKB=Q9BTE7 Q9BTE7 DCUN1D5 PTHR12281:SF6 RP42 RELATED DCN1-LIKE PROTEIN 5 ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;binding#GO:0005488;protein binding#GO:0005515;transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;positive regulation of macromolecule metabolic process#GO:0010604;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of protein modification by small protein conjugation or removal#GO:1903320;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;regulation of protein modification process#GO:0031399;positive regulation of metabolic process#GO:0009893;regulation of post-translational protein modification#GO:1901873;positive regulation of protein metabolic process#GO:0051247 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=37444|UniProtKB=Q8N7Z2 Q8N7Z2 GOLGA6L1 PTHR23143:SF31 TRICHOHYALIN-RELATED GOLGIN SUBFAMILY A MEMBER 6-LIKE PROTEIN 1-RELATED actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=8889|UniProtKB=P15259 P15259 PGAM2 PTHR11931:SF8 PHOSPHOGLYCERATE MUTASE PHOSPHOGLYCERATE MUTASE 2 intramolecular phosphotransferase activity#GO:0016868;catalytic activity#GO:0003824;intramolecular transferase activity#GO:0016866;isomerase activity#GO:0016853;phosphoglycerate mutase activity#GO:0004619 nucleotide catabolic process#GO:0009166;purine ribonucleoside diphosphate metabolic process#GO:0009179;generation of precursor metabolites and energy#GO:0006091;energy derivation by oxidation of organic compounds#GO:0015980;ADP metabolic process#GO:0046031;organophosphate metabolic process#GO:0019637;nucleobase-containing compound catabolic process#GO:0034655;glycolytic process#GO:0006096;purine ribonucleoside triphosphate metabolic process#GO:0009205;carbohydrate derivative metabolic process#GO:1901135;ribonucleotide catabolic process#GO:0009261;nucleobase-containing compound metabolic process#GO:0006139;nucleoside diphosphate metabolic process#GO:0009132;purine nucleotide catabolic process#GO:0006195;pyridine-containing compound metabolic process#GO:0072524;cellular respiration#GO:0045333;organophosphate catabolic process#GO:0046434;ribonucleoside diphosphate catabolic process#GO:0009191;purine ribonucleoside diphosphate catabolic process#GO:0009181;aerobic respiration#GO:0009060;hexose metabolic process#GO:0019318;primary metabolic process#GO:0044238;purine nucleoside triphosphate metabolic process#GO:0009144;nucleoside diphosphate catabolic process#GO:0009134;purine ribonucleotide catabolic process#GO:0009154;nucleoside phosphate catabolic process#GO:1901292;catabolic process#GO:0009056;nucleoside phosphate metabolic process#GO:0006753;carbohydrate derivative catabolic process#GO:1901136;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate metabolic process#GO:0005975;monosaccharide metabolic process#GO:0005996;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;ADP catabolic process#GO:0046032;glucose metabolic process#GO:0006006;purine-containing compound catabolic process#GO:0072523;purine nucleoside diphosphate catabolic process#GO:0009137;nucleobase-containing small molecule metabolic process#GO:0055086;ATP metabolic process#GO:0046034;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;nicotinamide nucleotide metabolic process#GO:0046496;ribonucleotide metabolic process#GO:0009259;purine nucleoside diphosphate metabolic process#GO:0009135;oxoacid metabolic process#GO:0043436;nucleotide metabolic process#GO:0009117;carbohydrate catabolic process#GO:0016052;carboxylic acid metabolic process#GO:0019752;phosphorus metabolic process#GO:0006793;monocarboxylic acid metabolic process#GO:0032787;ribonucleoside diphosphate metabolic process#GO:0009185;purine-containing compound metabolic process#GO:0072521;pyridine-containing compound catabolic process#GO:0072526;purine nucleotide metabolic process#GO:0006163;small molecule metabolic process#GO:0044281;small molecule catabolic process#GO:0044282;pyridine nucleotide catabolic process#GO:0019364;pyruvate metabolic process#GO:0006090 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 isomerase#PC00135;mutase#PC00160 Glycolysis#P00024>Phosphoglyceromutase#P00680 HUMAN|HGNC=21244|UniProtKB=Q8NC56 Q8NC56 LEMD2 PTHR13428:SF8 INNER NUCLEAR MEMBRANE PROTEIN MAN1 LEM DOMAIN CONTAINING PROTEIN LEM DOMAIN-CONTAINING PROTEIN 2 DNA binding#GO:0003677;chromatin DNA binding#GO:0031490;chromatin binding#GO:0003682;nucleic acid binding#GO:0003676;binding#GO:0005488 nuclear envelope organization#GO:0006998;cellular component organization or biogenesis#GO:0071840;nucleus organization#GO:0006997;membrane organization#GO:0061024;endomembrane system organization#GO:0010256;cellular component assembly#GO:0022607;membrane assembly#GO:0071709;cellular process#GO:0009987;nuclear membrane organization#GO:0071763;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle envelope#GO:0031967;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=34344|UniProtKB=A6NDX5 A6NDX5 ZNF840P PTHR24376:SF38 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 544-RELATED C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=23301|UniProtKB=P30039 P30039 PBLD PTHR13774:SF17 PHENAZINE BIOSYNTHESIS PROTEIN PHENAZINE BIOSYNTHESIS-LIKE DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=25761|UniProtKB=Q96BJ3 Q96BJ3 AIDA PTHR28654:SF1 AXIN INTERACTOR, DORSALIZATION-ASSOCIATED PROTEIN AXIN INTERACTOR, DORSALIZATION-ASSOCIATED PROTEIN regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;regulation of protein metabolic process#GO:0051246;negative regulation of signal transduction#GO:0009968;determination of bilateral symmetry#GO:0009855;regulation of MAPK cascade#GO:0043408;regulation of JNK cascade#GO:0046328;multicellular organism development#GO:0007275;dorsal/ventral pattern formation#GO:0009953;negative regulation of MAPK cascade#GO:0043409;negative regulation of protein metabolic process#GO:0051248;regulation of cell communication#GO:0010646;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;pattern specification process#GO:0007389;anatomical structure development#GO:0048856;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regionalization#GO:0003002;multicellular organismal process#GO:0032501;negative regulation of response to stimulus#GO:0048585;developmental process#GO:0032502;regulation of response to stimulus#GO:0048583;specification of symmetry#GO:0009799;negative regulation of cellular process#GO:0048523;regulation of protein modification process#GO:0031399 membrane#GO:0016020;cellular anatomical structure#GO:0110165 HUMAN|HGNC=56313|UniProtKB=A0A8V8TMC4 A0A8V8TMC4 CCNYL1B PTHR14248:SF39 CYCLIN Y, ISOFORM A CYCLIN-Y-LIKE PROTEIN 1B-RELATED kinase activator activity#GO:0019209;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;enzyme activator activity#GO:0008047;cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538;protein serine/threonine kinase activator activity#GO:0043539;protein kinase activator activity#GO:0030295;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;cyclin-dependent protein kinase regulator activity#GO:0019914;protein kinase regulator activity#GO:0019887 regulation of biological process#GO:0050789;regulation of canonical Wnt signaling pathway#GO:0060828;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111;regulation of cellular process#GO:0050794;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 HUMAN|HGNC=17638|UniProtKB=A8K0S8 A8K0S8 MEIS3P2 PTHR11850:SF332 HOMEOBOX PROTEIN TRANSCRIPTION FACTORS HOMEOBOX PROTEIN MEIS3-LIKE 1-RELATED sequence-specific DNA binding#GO:0043565;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;DNA-binding transcription activator activity#GO:0001216;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 eye development#GO:0001654;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;animal gross anatomical part developmental process#GO:0160108;central nervous system development#GO:0007417;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;positive regulation of cell population proliferation#GO:0008284;animal organ development#GO:0048513;multicellular organism development#GO:0007275;positive regulation of transcription by RNA polymerase II#GO:0045944;embryo development#GO:0009790;nervous system development#GO:0007399;head development#GO:0060322;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;sensory system development#GO:0048880;embryonic pattern specification#GO:0009880;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;positive regulation of biosynthetic process#GO:0009891;regulation of cell population proliferation#GO:0042127;pattern specification process#GO:0007389;positive regulation of RNA metabolic process#GO:0051254;visual system development#GO:0150063;regulation of cellular process#GO:0050794;animal organ morphogenesis#GO:0009887;regulation of macromolecule metabolic process#GO:0060255;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;sensory organ development#GO:0007423;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;multicellular organismal process#GO:0032501;positive regulation of DNA-templated transcription#GO:0045893;brain development#GO:0007420;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=12138|UniProtKB=A0JD32 A0JD32 TRAV38-2DV8 PTHR23267:SF484 IMMUNOGLOBULIN LIGHT CHAIN T CELL RECEPTOR ALPHA VARIABLE 38-2_DELTA VARIABLE 8 response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 protein-containing complex#GO:0032991 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=24731|UniProtKB=Q8NBF2 Q8NBF2 NHLRC2 PTHR46388:SF2 NHL REPEAT-CONTAINING PROTEIN 2 NHL REPEAT-CONTAINING PROTEIN 2 HUMAN|HGNC=26141|UniProtKB=Q9H6X5 Q9H6X5 C19orf44 PTHR22409:SF2 CHROMOSOME 19 OPEN READING FRAME 44 CHROMOSOME 19 OPEN READING FRAME 44 HUMAN|HGNC=32205|UniProtKB=A6NDN3 A6NDN3 GOLGA6B PTHR10881:SF44 GOLGIN SUBFAMILY A MEMBER-RELATED GOLGIN SUBFAMILY A MEMBER 6A-RELATED cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;Golgi organization#GO:0007030;cellular component organization or biogenesis#GO:0071840;endomembrane system organization#GO:0010256 Golgi apparatus#GO:0005794;organelle membrane#GO:0031090;cis-Golgi network#GO:0005801;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;cytoplasm#GO:0005737;Golgi cis cisterna#GO:0000137;endomembrane system#GO:0012505;Golgi cisterna#GO:0031985;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;Golgi stack#GO:0005795;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 membrane traffic protein#PC00150 HUMAN|HGNC=25035|UniProtKB=Q5VVQ6 Q5VVQ6 YOD1 PTHR13312:SF0 HIV-INDUCED PROTEIN-7-LIKE PROTEASE UBIQUITIN THIOESTERASE OTU1 deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;cysteine-type deubiquitinase activity#GO:0004843;cysteine-type peptidase activity#GO:0008234;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096 endoplasmic reticulum unfolded protein response#GO:0030968;response to stress#GO:0006950;signal transduction#GO:0007165;cellular process#GO:0009987;response to chemical#GO:0042221;biological regulation#GO:0065007;proteasomal protein catabolic process#GO:0010498;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;response to topologically incorrect protein#GO:0035966;signaling#GO:0023052;cellular response to unfolded protein#GO:0034620;response to endoplasmic reticulum stress#GO:0034976;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;cellular response to topologically incorrect protein#GO:0035967;response to unfolded protein#GO:0006986;cell communication#GO:0007154;protein metabolic process#GO:0019538;ERAD pathway#GO:0036503;intracellular signal transduction#GO:0035556 nucleus#GO:0005634;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 protease#PC00190;cysteine protease#PC00081;protein modifying enzyme#PC00260 HUMAN|HGNC=11337|UniProtKB=Q99909 Q99909 SSX3 PTHR14112:SF19 SYNOVIAL SARCOMA, X MEMBER PROTEIN SSX3 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HUMAN|HGNC=26080|UniProtKB=Q53H64 Q53H64 ANKRD40CL PTHR24192:SF2 ANKYRIN REPEAT DOMAIN 40 ANKRD40 C-TERMINAL-LIKE PROTEIN-RELATED HUMAN|HGNC=26186|UniProtKB=Q6P2H8 Q6P2H8 TMEM53 PTHR12265:SF30 TRANSMEMBRANE PROTEIN 53 TRANSMEMBRANE PROTEIN 53 HUMAN|HGNC=18128|UniProtKB=Q969S8 Q969S8 HDAC10 PTHR10625:SF43 HISTONE DEACETYLASE HDAC1-RELATED POLYAMINE DEACETYLASE HDAC10 deacylase activity#GO:0160215;catalytic activity#GO:0003824;histone deacetylase activity#GO:0004407;deacetylase activity#GO:0019213;catalytic activity, acting on a protein#GO:0140096;histone modifying activity#GO:0140993 regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;chromatin remodeling#GO:0006338;chromatin organization#GO:0006325;biological regulation#GO:0065007;cellular component organization#GO:0016043;regulation of macromolecule biosynthetic process#GO:0010556;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;cellular process#GO:0009987;regulation of biological process#GO:0050789 cytoplasm#GO:0005737;cytosol#GO:0005829 HUMAN|HGNC=20222|UniProtKB=Q9Y6S9 Q9Y6S9 RPS6KL1 PTHR15508:SF4 RIBOSOMAL PROTEIN S6 KINASE RIBOSOMAL PROTEIN S6 KINASE-LIKE 1 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 PDGF signaling pathway#P00047>p90RSK#P01142 HUMAN|HGNC=15302|UniProtKB=Q8NGQ2 Q8NGQ2 OR6Q1 PTHR26453:SF174 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 6Q1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;response to stimulus#GO:0050896;response to chemical#GO:0042221;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;detection of chemical stimulus#GO:0009593;system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;nervous system process#GO:0050877;sensory perception#GO:0007600 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=5438|UniProtKB=P01579 P01579 IFNG PTHR11419:SF0 INTERFERON GAMMA INTERFERON GAMMA molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;cytokine activity#GO:0005125;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018 multicellular organismal process#GO:0032501;biological regulation#GO:0065007;response to other organism#GO:0051707;adaptive immune response#GO:0002250;immune response#GO:0006955;macrophage activation#GO:0042116;innate immune response#GO:0045087;response to external stimulus#GO:0009605;defense response#GO:0006952;regulation of cellular process#GO:0050794;response to external biotic stimulus#GO:0043207;leukocyte activation#GO:0045321;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;cytokine-mediated signaling pathway#GO:0019221;cell activation#GO:0001775;response to cytokine#GO:0034097;response to chemical#GO:0042221;myeloid leukocyte activation#GO:0002274;defense response to other organism#GO:0098542;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;signal transduction#GO:0007165;defense response to symbiont#GO:0140546;response to type II interferon#GO:0034341;cellular process#GO:0009987;humoral immune response#GO:0006959;cell surface receptor signaling pathway#GO:0007166;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;response to peptide#GO:1901652;immune system process#GO:0002376 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 cytokine#PC00083;interferon superfamily#PC00127;intercellular signal molecule#PC00207 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>INFgamma#P00878;Interferon-gamma signaling pathway#P00035>Interferongamma#P00954 HUMAN|HGNC=16459|UniProtKB=Q9NYK6 Q9NYK6 EURL PTHR15961:SF3 PROTEIN EURL HOMOLOG PROTEIN EURL HOMOLOG animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;anatomical structure development#GO:0048856;system development#GO:0048731;regulation of biological process#GO:0050789;forebrain development#GO:0030900;cell differentiation#GO:0030154;central nervous system development#GO:0007417;regulation of developmental process#GO:0050793;central nervous system neuron differentiation#GO:0021953;positive regulation of developmental process#GO:0051094;neuron differentiation#GO:0030182;developmental process#GO:0032502;cellular developmental process#GO:0048869;animal organ development#GO:0048513;multicellular organism development#GO:0007275;neurogenesis#GO:0022008;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;multicellular organismal process#GO:0032501;brain development#GO:0007420;nervous system development#GO:0007399;head development#GO:0060322;biological regulation#GO:0065007 HUMAN|HGNC=44651|UniProtKB=H3BTG2 H3BTG2 TEX46 PTHR39412:SF1 TESTIS-EXPRESSED PROTEIN 46 TESTIS-EXPRESSED PROTEIN 46 fertilization#GO:0009566;reproductive process#GO:0022414;sexual reproduction#GO:0019953;single fertilization#GO:0007338 HUMAN|HGNC=24695|UniProtKB=Q5XKK7 Q5XKK7 FAM219B PTHR31281:SF2 PROTEIN FAM219A PROTEIN FAM219B HUMAN|HGNC=31668|UniProtKB=Q2TAP0 Q2TAP0 GOLGA7B PTHR13254:SF2 GOLGI AUTOANTIGEN, GOLGIN SUBFAMILY A, 7 GOLGIN SUBFAMILY A MEMBER 7B establishment of protein localization#GO:0045184;cellular process#GO:0009987;establishment of protein localization to membrane#GO:0090150;protein targeting#GO:0006605;localization within membrane#GO:0051668;protein targeting to membrane#GO:0006612;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234 catalytic complex#GO:1902494;transferase complex#GO:1990234;protein-containing complex#GO:0032991 HUMAN|HGNC=29828|UniProtKB=Q6TFL3 Q6TFL3 CCDC171 PTHR47899:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 171 COILED-COIL DOMAIN-CONTAINING PROTEIN 171 HUMAN|HGNC=12482|UniProtKB=P62253 P62253 UBE2G1 PTHR24067:SF3 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2 G1 catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;ubiquitin conjugating enzyme activity#GO:0061631;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-like protein conjugating enzyme activity#GO:0061650;ubiquitin-protein transferase activity#GO:0004842 proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;proteasomal protein catabolic process#GO:0010498;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;protein modification process#GO:0036211;catabolic process#GO:0009056 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 Ubiquitin proteasome pathway#P00060>E2#P01491 HUMAN|HGNC=44654|UniProtKB=H3BRN8 H3BRN8 PIERCE2 PTHR20899:SF4 PIERCE HOMOLOG PIERCER OF MICROTUBULE WALL 2 PROTEIN HUMAN|HGNC=16824|UniProtKB=P49019 P49019 HCAR3 PTHR46048:SF5 HYDROXYCARBOXYLIC ACID RECEPTOR 2 HYDROXYCARBOXYLIC ACID RECEPTOR 3 signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=4739|UniProtKB=P16104 P16104 H2AX PTHR23430:SF199 HISTONE H2A HISTONE H2AX structural molecule activity#GO:0005198 heterochromatin organization#GO:0070828;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;chromatin organization#GO:0006325;cellular component assembly#GO:0022607;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;response to stress#GO:0006950;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of gene expression, epigenetic#GO:0045814;cellular component organization or biogenesis#GO:0071840;DNA damage response#GO:0006974;negative regulation of cellular process#GO:0048523;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;heterochromatin formation#GO:0031507;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;cellular response to stress#GO:0033554 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular membraneless organelle#GO:0043232;nucleosome#GO:0000786;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-DNA complex#GO:0032993;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=9759|UniProtKB=P61026 P61026 RAB10 PTHR47980:SF87 LD44762P RAS-RELATED PROTEIN RAB-10 vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of localization#GO:0051234;exocytosis#GO:0006887;vesicle-mediated transport to the plasma membrane#GO:0098876;endosomal transport#GO:0016197;intracellular transport#GO:0046907;transport#GO:0006810;endocytic recycling#GO:0032456;export from cell#GO:0140352;cellular localization#GO:0051641;secretion#GO:0046903;localization#GO:0051179;secretion by cell#GO:0032940;localization within membrane#GO:0051668 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;recycling endosome#GO:0055037;Golgi apparatus#GO:0005794;cytoplasm#GO:0005737;endomembrane system#GO:0012505;secretory vesicle#GO:0099503;membrane#GO:0016020 HUMAN|HGNC=23705|UniProtKB=Q9ULM2 Q9ULM2 ZNF490 PTHR24377:SF1004 IP01015P-RELATED ZINC FINGER PROTEIN 490 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=16386|UniProtKB=Q96SU4 Q96SU4 OSBPL9 PTHR10972:SF200 OXYSTEROL-BINDING PROTEIN-RELATED OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 9 lipid binding#GO:0008289;steroid binding#GO:0005496;sterol binding#GO:0032934;binding#GO:0005488 cytosol#GO:0005829;membrane#GO:0016020;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 transfer/carrier protein#PC00219 HUMAN|HGNC=12554|UniProtKB=P16662 P16662 UGT2B7 PTHR48043:SF87 EG:EG0003.4 PROTEIN-RELATED UDP-GLUCURONOSYLTRANSFERASE 2B7 glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194;hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;glucuronosyltransferase activity#GO:0015020;catalytic activity#GO:0003824 cellular process#GO:0009987;regulation of hormone levels#GO:0010817;primary metabolic process#GO:0044238;biological regulation#GO:0065007;steroid metabolic process#GO:0008202;hormone metabolic process#GO:0042445;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;regulation of biological quality#GO:0065008;estrogen metabolic process#GO:0008210 Nicotine degradation#P05914>UGT2B7#P05980 HUMAN|HGNC=11015|UniProtKB=O14863 O14863 SLC30A4 PTHR11562:SF27 CATION EFFLUX PROTEIN/ ZINC TRANSPORTER PROTON-COUPLED ZINC ANTIPORTER SLC30A4-RELATED zinc ion transmembrane transporter activity#GO:0005385;transition metal ion transmembrane transporter activity#GO:0046915;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;monoatomic cation transmembrane transporter activity#GO:0008324 establishment of localization#GO:0051234;response to metal ion#GO:0010038;transport#GO:0006810;response to chemical#GO:0042221;monoatomic cation transmembrane transport#GO:0098655;zinc ion transport#GO:0006829;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;zinc ion transmembrane transport#GO:0071577;transition metal ion transport#GO:0000041;response to stimulus#GO:0050896;metal ion transport#GO:0030001 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227 HUMAN|HGNC=11776|UniProtKB=Q15583 Q15583 TGIF1 PTHR11850:SF425 HOMEOBOX PROTEIN TRANSCRIPTION FACTORS HOMEOBOX PROTEIN TGIF1 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 Gonadotropin-releasing hormone receptor pathway#P06664>TGIF1#P06725 HUMAN|HGNC=16446|UniProtKB=Q9BXL6 Q9BXL6 CARD14 PTHR14559:SF1 CASPASE RECRUITMENT DOMAIN FAMILY CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 14 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;signaling adaptor activity#GO:0035591 positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;signaling#GO:0023052;regulation of cell communication#GO:0010646;regulation of intracellular signal transduction#GO:1902531;regulation of immune response#GO:0050776;regulation of signaling#GO:0023051;cell communication#GO:0007154;positive regulation of signaling#GO:0023056;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of cellular process#GO:0048522;regulation of canonical NF-kappaB signal transduction#GO:0043122;cellular process#GO:0009987;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;positive regulation of canonical NF-kappaB signal transduction#GO:0043123 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=5175|UniProtKB=P52594 P52594 AGFG1 PTHR46134:SF1 DRONGO, ISOFORM F ARF-GAP DOMAIN AND FG REPEAT-CONTAINING PROTEIN 1 organelle assembly#GO:0070925;cellular component assembly involved in morphogenesis#GO:0010927;sexual reproduction#GO:0019953;spermatid development#GO:0007286;anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;multicellular organismal reproductive process#GO:0048609;developmental process involved in reproduction#GO:0003006;germ cell development#GO:0007281;reproductive process#GO:0022414;developmental process#GO:0032502;spermatogenesis#GO:0007283;nucleus organization#GO:0006997;cellular developmental process#GO:0048869;male gamete generation#GO:0048232;intermediate filament-based process#GO:0045103;spermatid differentiation#GO:0048515;acrosome assembly#GO:0001675;intermediate filament organization#GO:0045109;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;intermediate filament cytoskeleton organization#GO:0045104;cell differentiation#GO:0030154;gamete generation#GO:0007276;cell development#GO:0048468;cellular process involved in reproduction in multicellular organism#GO:0022412;cellular anatomical entity morphogenesis#GO:0032989;cellular component organization or biogenesis#GO:0071840;vesicle organization#GO:0016050;anatomical structure formation involved in morphogenesis#GO:0048646;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cellular component assembly#GO:0022607;endomembrane system organization#GO:0010256;cytoskeleton organization#GO:0007010 membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982 HUMAN|HGNC=3266|UniProtKB=P20042 P20042 EIF2S2 PTHR23001:SF24 EUKARYOTIC TRANSLATION INITIATION FACTOR EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 2 translation factor activity#GO:0180051;translation initiation factor activity#GO:0003743;translation initiation factor binding#GO:0031369;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;RNA binding#GO:0003723;protein binding#GO:0005515 cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;cellular component assembly#GO:0022607;biosynthetic process#GO:0009058;metabolic process#GO:0008152;protein-RNA complex organization#GO:0071826;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-containing complex organization#GO:0043933;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;protein-containing complex assembly#GO:0065003;protein biosynthetic process#GO:0160307;cytoplasmic translation#GO:0002181;ribonucleoprotein complex biogenesis#GO:0022613;cytoplasmic translational initiation#GO:0002183;translational initiation#GO:0006413;translation#GO:0006412;protein-RNA complex assembly#GO:0022618;protein metabolic process#GO:0019538 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 translational protein#PC00263;translation initiation factor#PC00224;translation factor#PC00223 HUMAN|HGNC=24131|UniProtKB=Q9UHQ4 Q9UHQ4 BCAP29 PTHR12701:SF5 BCR-ASSOCIATED PROTEIN, BAP B-CELL RECEPTOR-ASSOCIATED PROTEIN 29 molecular carrier activity#GO:0140104;ATP-dependent activity#GO:0140657;protein carrier activity#GO:0140597 response to endoplasmic reticulum stress#GO:0034976;regulation of protein catabolic process#GO:0042176;ERAD pathway#GO:0036503;positive regulation of protein catabolic process#GO:0045732;protein metabolic process#GO:0019538;localization#GO:0051179;cellular response to stimulus#GO:0051716;positive regulation of ubiquitin-dependent protein catabolic process#GO:2000060;primary metabolic process#GO:0044238;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;transport#GO:0006810;regulation of catabolic process#GO:0009894;intracellular protein localization#GO:0008104;positive regulation of catabolic process#GO:0009896;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;macromolecule localization#GO:0033036;biological regulation#GO:0065007;positive regulation of protein metabolic process#GO:0051247;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;protein transport#GO:0015031;positive regulation of metabolic process#GO:0009893;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;cellular process#GO:0009987;establishment of protein localization#GO:0045184;positive regulation of biological process#GO:0048518;response to stress#GO:0006950;regulation of protein metabolic process#GO:0051246;proteasomal protein catabolic process#GO:0010498;response to chemical#GO:0042221;positive regulation of macromolecule metabolic process#GO:0010604 membrane#GO:0016020;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum membrane#GO:0005789;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HUMAN|HGNC=19660|UniProtKB=Q6YBV0 Q6YBV0 SLC36A4 PTHR22950:SF190 AMINO ACID TRANSPORTER NEUTRAL AMINO ACID UNIPORTER 4 L-amino acid transmembrane transporter activity#GO:0015179;amino acid transmembrane transporter activity#GO:0015171;neutral L-amino acid transmembrane transporter activity#GO:0015175;transporter activity#GO:0005215;carboxylic acid transmembrane transporter activity#GO:0046943;transmembrane transporter activity#GO:0022857 cellular process#GO:0009987;L-amino acid transport#GO:0015807;nitrogen compound transport#GO:0071705;alanine transport#GO:0032328;transport#GO:0006810;amino acid transport#GO:0006865;organic acid transport#GO:0015849;carboxylic acid transport#GO:0046942;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;amino acid transmembrane transport#GO:0003333;neutral amino acid transport#GO:0015804 intracellular organelle#GO:0043229;vacuolar membrane#GO:0005774;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;vacuole#GO:0005773 secondary carrier transporter#PC00258;amino acid transporter#PC00046 HUMAN|HGNC=4537|UniProtKB=Q9BPV8 Q9BPV8 P2RY13 PTHR24233:SF10 P2Y PURINOCEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR P2Y PURINOCEPTOR 13 transmembrane signaling receptor activity#GO:0004888;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=10779|UniProtKB=Q5T4F7 Q5T4F7 SFRP5 PTHR11309:SF46 FRIZZLED SECRETED FRIZZLED-RELATED PROTEIN 5 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;protein binding#GO:0005515;Wnt-protein binding#GO:0017147;transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488 biological regulation#GO:0065007;signaling#GO:0023052;Wnt signaling pathway#GO:0016055;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;non-canonical Wnt signaling pathway#GO:0035567;canonical Wnt signaling pathway#GO:0060070;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;extracellular region#GO:0005576 transmembrane signal receptor#PC00197 Wnt signaling pathway#P00057>sFRP#P01434 HUMAN|HGNC=28212|UniProtKB=Q9BRA0 Q9BRA0 NAA38 PTHR10701:SF5 SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N N-ALPHA-ACETYLTRANSFERASE 38, NATC AUXILIARY SUBUNIT RNA splicing factor#PC00148 HUMAN|HGNC=16027|UniProtKB=Q5JSP0 Q5JSP0 FGD3 PTHR12673:SF14 FACIOGENITAL DYSPLASIA PROTEIN FYVE, RHOGEF AND PH DOMAIN-CONTAINING PROTEIN 3 molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;guanyl-nucleotide exchange factor activity#GO:0005085 cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection organization#GO:0120036;cell projection organization#GO:0030030;cellular component assembly#GO:0022607;cell projection assembly#GO:0030031;cellular process#GO:0009987;filopodium assembly#GO:0046847;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection assembly#GO:0120031 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022 HUMAN|HGNC=24374|UniProtKB=O43169 O43169 CYB5B PTHR19359:SF158 CYTOCHROME B5 CYTOCHROME B5 TYPE B binding#GO:0005488;heme binding#GO:0020037;tetrapyrrole binding#GO:0046906 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;outer membrane#GO:0019867;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;mitochondrion#GO:0005739;mitochondrial outer membrane#GO:0005741;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;organelle outer membrane#GO:0031968;cytoplasm#GO:0005737;membrane#GO:0016020;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966 oxidoreductase#PC00176 HUMAN|HGNC=21740|UniProtKB=Q6ZV73 Q6ZV73 FGD6 PTHR12673:SF12 FACIOGENITAL DYSPLASIA PROTEIN FYVE, RHOGEF AND PH DOMAIN-CONTAINING PROTEIN 6 molecular function regulator activity#GO:0098772;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;guanyl-nucleotide exchange factor activity#GO:0005085 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 G-protein modulator#PC00022;guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=1076|UniProtKB=P36894 P36894 BMPR1A PTHR23255:SF50 TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A transmembrane receptor protein serine/threonine kinase activity#GO:0004675;phosphotransferase activity, alcohol group as acceptor#GO:0016773;molecular transducer activity#GO:0060089;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;transmembrane signaling receptor activity#GO:0004888;catalytic activity, acting on a protein#GO:0140096;signaling receptor activity#GO:0038023;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transforming growth factor beta receptor activity#GO:0005024 pattern specification process#GO:0007389;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;cellular response to growth factor stimulus#GO:0071363;response to endogenous stimulus#GO:0009719;dorsal/ventral pattern formation#GO:0009953;regulation of biological process#GO:0050789;BMP signaling pathway#GO:0030509;cellular response to stimulus#GO:0051716;response to growth factor#GO:0070848;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;signaling#GO:0023052;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;response to BMP#GO:0071772;cellular response to BMP stimulus#GO:0071773;developmental process#GO:0032502;cell surface receptor signaling pathway#GO:0007166;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;signal transduction#GO:0007165;cellular process#GO:0009987;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;regionalization#GO:0003002;multicellular organismal process#GO:0032501;biological regulation#GO:0065007 membrane#GO:0016020;cell periphery#GO:0071944;signaling receptor complex#GO:0043235;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886 serine/threonine protein kinase receptor#PC00205 Gonadotropin-releasing hormone receptor pathway#P06664>BMPR-IA/IB/II#P06740;TGF-beta signaling pathway#P00052>TGFbetareceptors#P01283;TGF-beta signaling pathway#P00052>TGFbetareceptor I#P01278;Wnt signaling pathway#P00057>TGFbetaactivated Kinase-1#P01442 HUMAN|HGNC=8252|UniProtKB=Q9GZK4 Q9GZK4 OR2H1 PTHR26453:SF323 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2H1 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;nervous system process#GO:0050877;sensory perception#GO:0007600;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;response to chemical#GO:0042221;response to stimulus#GO:0050896;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;detection of chemical stimulus#GO:0009593 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=9540|UniProtKB=P49720 P49720 PSMB3 PTHR11599:SF185 PROTEASOME SUBUNIT ALPHA/BETA PROTEASOME SUBUNIT BETA TYPE-3 proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498 membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;endopeptidase complex#GO:1905369;intracellular organelle#GO:0043229;peptidase complex#GO:1905368;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;proteasome complex#GO:0000502;nucleus#GO:0005634;cytosol#GO:0005829 protein modifying enzyme#PC00260;protease#PC00190 Parkinson disease#P00049>20S proteasome#P01227 HUMAN|HGNC=547|UniProtKB=O76027 O76027 ANXA9 PTHR10502:SF122 ANNEXIN ANNEXIN A9 lipid binding#GO:0008289;phosphatidylserine binding#GO:0001786;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;phospholipid binding#GO:0005543;anion binding#GO:0043168 cellular process#GO:0009987;cell adhesion#GO:0007155 membrane#GO:0016020;vesicle membrane#GO:0012506;cell periphery#GO:0071944;nucleus#GO:0005634;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;plasma membrane#GO:0005886;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227 calcium-binding protein#PC00060 HUMAN|HGNC=30099|UniProtKB=Q8NG41 Q8NG41 NPB PTHR28553:SF1 NEUROPEPTIDE B NEUROPEPTIDE B protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488;G protein-coupled receptor binding#GO:0001664 cell communication#GO:0007154;feeding behavior#GO:0007631;G protein-coupled receptor signaling pathway#GO:0007186;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;multicellular organismal process#GO:0032501;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789 HUMAN|HGNC=18649|UniProtKB=Q9UBP9 Q9UBP9 GULP1 PTHR11232:SF78 PHOSPHOTYROSINE INTERACTION DOMAIN-CONTAINING FAMILY MEMBER PTB DOMAIN-CONTAINING ENGULFMENT ADAPTER PROTEIN 1 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;signaling adaptor activity#GO:0035591 endocytosis#GO:0006897;membrane organization#GO:0061024;cellular component organization#GO:0016043;cellular process#GO:0009987;import into cell#GO:0098657;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;localization#GO:0051179;phagocytosis, engulfment#GO:0006911;phagocytosis#GO:0006909;transport#GO:0006810;membrane invagination#GO:0010324 scaffold/adaptor protein#PC00226 HUMAN|HGNC=7905|UniProtKB=O15259 O15259 NPHP1 PTHR15176:SF1 NEPHROCYSTIN NEPHROCYSTIN-1 localization#GO:0051179;non-motile cilium assembly#GO:1905515;cilium organization#GO:0044782;organelle assembly#GO:0070925;cell projection organization#GO:0030030;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cellular component organization or biogenesis#GO:0071840;intracellular protein localization#GO:0008104;plasma membrane bounded cell projection assembly#GO:0120031;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;cellular component biogenesis#GO:0044085;macromolecule localization#GO:0033036;organelle organization#GO:0006996;cell projection assembly#GO:0030031;cellular process#GO:0009987 membrane-bounded organelle#GO:0043227;cilium#GO:0005929;ciliary transition zone#GO:0035869;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;ciliary base#GO:0097546 cell junction protein#PC00070 HUMAN|HGNC=3659|UniProtKB=Q99689 Q99689 FEZ1 PTHR12394:SF4 ZYGIN FASCICULATION AND ELONGATION PROTEIN ZETA-1 cell projection#GO:0042995;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165;neuron projection#GO:0043005;axon#GO:0030424 HUMAN|HGNC=29550|UniProtKB=Q9NPQ8 Q9NPQ8 RIC8A PTHR12425:SF4 SYNEMBRYN CHAPERONE RIC-8A molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;protein binding#GO:0005515;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;guanyl-nucleotide exchange factor activity#GO:0005085;binding#GO:0005488 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;cytosol#GO:0005829;membrane#GO:0016020 HUMAN|HGNC=18349|UniProtKB=Q13268 Q13268 DHRS2 PTHR43943:SF3 DEHYDROGENASE/REDUCTASE (SDR FAMILY) MEMBER 4 DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 2, MITOCHONDRIAL alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;alcohol dehydrogenase (NADP+) activity#GO:0008106 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=26660|UniProtKB=A6NC78 A6NC78 GOLGA8IP PTHR10881:SF62 GOLGIN SUBFAMILY A MEMBER-RELATED GOLGIN SUBFAMILY A CONSERVED DOMAIN-CONTAINING PROTEIN-RELATED cellular process#GO:0009987;Golgi organization#GO:0007030;cellular component organization#GO:0016043;organelle organization#GO:0006996;endomembrane system organization#GO:0010256;cellular component organization or biogenesis#GO:0071840 membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;endomembrane system#GO:0012505;Golgi cisterna#GO:0031985;cytoplasm#GO:0005737;Golgi cis cisterna#GO:0000137;Golgi apparatus#GO:0005794;organelle membrane#GO:0031090;cis-Golgi network#GO:0005801;Golgi stack#GO:0005795;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984 membrane traffic protein#PC00150 HUMAN|HGNC=11327|UniProtKB=Q08945 Q08945 SSRP1 PTHR45849:SF7 FACT COMPLEX SUBUNIT SSRP1 FACT COMPLEX SUBUNIT SSRP1 nucleosome binding#GO:0031491;protein-containing complex binding#GO:0044877;protein binding#GO:0005515;histone binding#GO:0042393;chromatin binding#GO:0003682;binding#GO:0005488 regulation of biological process#GO:0050789;regulation of chromatin organization#GO:1902275;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;biological regulation#GO:0065007 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;transcription elongation factor complex#GO:0008023;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle lumen#GO:0043233;chromosome#GO:0005694;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;chromatin#GO:0000785;membrane-enclosed lumen#GO:0031974 HUMAN|HGNC=20256|UniProtKB=Q5VUG0 Q5VUG0 SFMBT2 PTHR12247:SF62 POLYCOMB GROUP PROTEIN SCM-LIKE WITH FOUR MBT DOMAINS PROTEIN 2 chromatin binding#GO:0003682;histone binding#GO:0042393;binding#GO:0005488;protein binding#GO:0005515 negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of metabolic process#GO:0009892 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=24561|UniProtKB=Q68CL5 Q68CL5 TPGS2 PTHR31854:SF2 TUBULIN POLYGLUTAMYLASE COMPLEX SUBUNIT 2 TUBULIN POLYGLUTAMYLASE COMPLEX SUBUNIT 2 microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=4617|UniProtKB=P49841 P49841 GSK3B PTHR24057:SF8 GLYCOGEN SYNTHASE KINASE-3 ALPHA GLYCOGEN SYNTHASE KINASE-3 BETA catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;binding#GO:0005488;protein binding#GO:0005515;phosphotransferase activity, alcohol group as acceptor#GO:0016773;beta-catenin binding#GO:0008013;protein kinase activity#GO:0004672 response to insulin#GO:0032868;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of cell communication#GO:0010646;regulation of microtubule-based process#GO:0032886;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;negative regulation of response to stimulus#GO:0048585;response to peptide hormone#GO:0043434;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;positive regulation of neuron apoptotic process#GO:0043525;regulation of cell projection organization#GO:0031344;cellular response to insulin stimulus#GO:0032869;regulation of response to stimulus#GO:0048583;positive regulation of catabolic process#GO:0009896;regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of catabolic process#GO:0009894;negative regulation of biological process#GO:0048519;regulation of autophagy#GO:0010506;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;cellular response to hormone stimulus#GO:0032870;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;regulation of Wnt signaling pathway#GO:0030111;negative regulation of signaling#GO:0023057;cellular response to chemical stimulus#GO:0070887;regulation of signaling#GO:0023051;insulin receptor signaling pathway#GO:0008286;negative regulation of cell communication#GO:0010648;regulation of canonical Wnt signaling pathway#GO:0060828;cellular process#GO:0009987;regulation of neuron projection development#GO:0010975;positive regulation of biological process#GO:0048518;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;regulation of proteasomal protein catabolic process#GO:0061136;positive regulation of macromolecule metabolic process#GO:0010604;negative regulation of signal transduction#GO:0009968;positive regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032436;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;positive regulation of ubiquitin-dependent protein catabolic process#GO:2000060;regulation of cytoskeleton organization#GO:0051493;negative regulation of TOR signaling#GO:0032007;cellular response to peptide hormone stimulus#GO:0071375;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434;cell communication#GO:0007154;regulation of protein catabolic process#GO:0042176;positive regulation of protein catabolic process#GO:0045732;response to nitrogen compound#GO:1901698;negative regulation of Wnt signaling pathway#GO:0030178;cellular response to nitrogen compound#GO:1901699;regulation of signal transduction#GO:0009966;developmental process#GO:0032502;cellular developmental process#GO:0048869;response to endogenous stimulus#GO:0009719;regulation of programmed cell death#GO:0043067;positive regulation of proteasomal protein catabolic process#GO:1901800;positive regulation of programmed cell death#GO:0043068;cellular response to endogenous stimulus#GO:0071495;cell differentiation#GO:0030154;signaling#GO:0023052;regulation of intracellular signal transduction#GO:1902531;negative regulation of canonical Wnt signaling pathway#GO:0090090;positive regulation of protein metabolic process#GO:0051247;response to oxygen-containing compound#GO:1901700;negative regulation of intracellular signal transduction#GO:1902532;positive regulation of metabolic process#GO:0009893;response to hormone#GO:0009725;regulation of protein metabolic process#GO:0051246;regulation of neuron apoptotic process#GO:0043523;positive regulation of autophagy#GO:0010508;regulation of TOR signaling#GO:0032006;response to chemical#GO:0042221;regulation of microtubule cytoskeleton organization#GO:0070507;cell surface receptor signaling pathway#GO:0007166;regulation of apoptotic process#GO:0042981;positive regulation of apoptotic process#GO:0043065 intracellular protein-containing complex#GO:0140535;cell junction#GO:0030054;cytoplasm#GO:0005737;somatodendritic compartment#GO:0036477;glutamatergic synapse#GO:0098978;protein-containing complex#GO:0032991;nucleus#GO:0005634;neuron projection#GO:0043005;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;dendritic tree#GO:0097447;axon#GO:0030424;dendrite#GO:0030425;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226 non-receptor serine/threonine protein kinase#PC00167 Cadherin signaling pathway#P00012>GSK3beta#P00477;Hedgehog signaling pathway#P00025>GSK3#P00692;Interleukin signaling pathway#P00036>GSK3#P00976;Ras Pathway#P04393>GSK3#P04546;CCKR signaling map#P06959>GSK3beta#P07199;Gonadotropin-releasing hormone receptor pathway#P06664>GSK3#P06827;Angiogenesis#P00005>GSK3beta#P00211;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GSK#P00714;Wnt signaling pathway#P00057>Glycogen Synthase Kinase-3Beta#P01441;Alzheimer disease-presenilin pathway#P00004>GSK-3beta#P00175;PI3 kinase pathway#P00048>GSK3#P01181;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>GSK-3#P00902;PDGF signaling pathway#P00047>GSK3#P01153 HUMAN|HGNC=9225|UniProtKB=O75387 O75387 SLC43A1 PTHR20766:SF0 LARGE NEUTRAL AMINO ACIDS TRANSPORTER SMALL SUBUNIT 4-LIKE ISOFORM X1 LARGE NEUTRAL AMINO ACIDS TRANSPORTER SMALL SUBUNIT 3 carboxylic acid transmembrane transporter activity#GO:0046943;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;neutral L-amino acid transmembrane transporter activity#GO:0015175;amino acid transmembrane transporter activity#GO:0015171;L-amino acid transmembrane transporter activity#GO:0015179 transport#GO:0006810;amino acid transport#GO:0006865;neutral amino acid transport#GO:0015804;establishment of localization#GO:0051234;localization#GO:0051179 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HUMAN|HGNC=9659|UniProtKB=P35236 P35236 PTPN7 PTHR19134:SF527 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 7 hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725;phosphoprotein phosphatase activity#GO:0004721;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791 cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HUMAN|HGNC=18868|UniProtKB=Q6P2D8 Q6P2D8 XRRA1 PTHR22710:SF2 X-RAY RADIATION RESISTANCE ASSOCIATED PROTEIN 1 XRRA1 X-RAY RADIATION RESISTANCE-ASSOCIATED PROTEIN 1 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=11273|UniProtKB=Q13813 Q13813 SPTAN1 PTHR11915:SF427 SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN SPECTRIN ALPHA CHAIN, NON-ERYTHROCYTIC 1 binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;actin filament binding#GO:0051015;protein binding#GO:0005515;protein-containing complex binding#GO:0044877 cellular component organization or biogenesis#GO:0071840;actin cytoskeleton organization#GO:0030036;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component organization#GO:0016043;actin filament-based process#GO:0030029;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cell projection#GO:0042995;cortical cytoskeleton#GO:0030863;actin cytoskeleton#GO:0015629;cell cortex#GO:0005938;membraneless organelle#GO:0043228;cell junction#GO:0030054;cytoskeleton#GO:0005856;cytoplasm#GO:0005737;cortical actin cytoskeleton#GO:0030864;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=30370|UniProtKB=Q5T9S5 Q5T9S5 CCDC18 PTHR18875:SF8 SARCOMA ANTIGEN NY-SAR-24/CYTOSKELETAL PROTEIN SOJO COILED-COIL DOMAIN-CONTAINING PROTEIN 18 microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;centriolar satellite#GO:0034451;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;microtubule organizing center#GO:0005815;centrosome#GO:0005813;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 cytoskeletal protein#PC00085 HUMAN|HGNC=289|UniProtKB=P25098 P25098 GRK2 PTHR24355:SF22 G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE G PROTEIN-COUPLED RECEPTOR KINASE 2 catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;G protein-coupled receptor binding#GO:0001664;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein binding#GO:0005515;protein kinase activity#GO:0004672;binding#GO:0005488;signaling receptor binding#GO:0005102;protein serine/threonine kinase activity#GO:0004674 regulation of G protein-coupled receptor signaling pathway#GO:0008277;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;regulation of system process#GO:0044057;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of multicellular organismal process#GO:0051239;negative regulation of signal transduction#GO:0009968;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of response to stimulus#GO:0048585;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;G protein-coupled receptor signaling pathway#GO:0007186;negative regulation of cell communication#GO:0010648;regulation of biological quality#GO:0065008;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;negative regulation of G protein-coupled receptor signaling pathway#GO:0045744;negative regulation of biological process#GO:0048519;regulation of heart contraction#GO:0008016;regulation of cell communication#GO:0010646;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 non-receptor serine/threonine protein kinase#PC00167 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GPRK#P00741;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GPRK#P00701;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>GPRK#P00840;Parkinson disease#P00049>GRK#P01234;Angiotensin II-stimulated signaling through G proteins and beta-arrestin#P05911>GRK2#P05943 HUMAN|HGNC=26070|UniProtKB=Q9BVS5 Q9BVS5 TRMT61B PTHR12133:SF1 TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE, MITOCHONDRIAL catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring one-carbon groups#GO:0016741;tRNA methyltransferase activity#GO:0008175;catalytic activity, acting on RNA#GO:0140098;RNA methyltransferase activity#GO:0008173;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;catalytic activity, acting on a tRNA#GO:0140101 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;tRNA modification#GO:0006400;RNA biosynthetic process#GO:0032774;RNA modification#GO:0009451;macromolecule methylation#GO:0043414;nucleic acid biosynthetic process#GO:0141187;RNA methylation#GO:0001510;methylation#GO:0032259;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;tRNA methylation#GO:0030488;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;gene expression#GO:0010467;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033 catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex#GO:1990234;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;methyltransferase complex#GO:0034708;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 RNA methyltransferase#PC00033;RNA metabolism protein#PC00031 HUMAN|HGNC=27960|UniProtKB=Q695T7 Q695T7 SLC6A19 PTHR11616:SF125 SODIUM/CHLORIDE DEPENDENT TRANSPORTER SODIUM-DEPENDENT NEUTRAL AMINO ACID TRANSPORTER B(0)AT1 neutral L-amino acid transmembrane transporter activity#GO:0015175;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;amino acid transmembrane transporter activity#GO:0015171 transport#GO:0006810;amino acid transport#GO:0006865;establishment of localization#GO:0051234;neutral amino acid transport#GO:0015804;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;sodium ion transport#GO:0006814;sodium ion transmembrane transport#GO:0035725;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001 cell projection membrane#GO:0031253;cluster of actin-based cell projections#GO:0098862;apical part of cell#GO:0045177;plasma membrane region#GO:0098590;brush border membrane#GO:0031526;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane#GO:0005886;plasma membrane bounded cell projection#GO:0120025;apical plasma membrane#GO:0016324;membrane#GO:0016020;cell periphery#GO:0071944;brush border#GO:0005903 primary active transporter#PC00068 Adrenaline and noradrenaline biosynthesis#P00001>amine translocator#P00068 HUMAN|HGNC=7599|UniProtKB=Q12965 Q12965 MYO1E PTHR13140:SF341 MYOSIN UNCONVENTIONAL MYOSIN-IE macromolecular conformation isomerase activity#GO:0120543;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;polypeptide conformation or assembly isomerase activity#GO:0120544;microfilament motor activity#GO:0000146;isomerase activity#GO:0016853;cytoskeletal motor activity#GO:0003774 localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;import into cell#GO:0098657;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;actin filament-based process#GO:0030029;transport#GO:0006810;endocytosis#GO:0006897;actin cytoskeleton organization#GO:0030036;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987 cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;membrane#GO:0016020;cell periphery#GO:0071944;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;actin cytoskeleton#GO:0015629;actin-based cell projection#GO:0098858;microvillus#GO:0005902;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025 actin binding motor protein#PC00040 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HUMAN|HGNC=20068|UniProtKB=Q9H9J4 Q9H9J4 USP42 PTHR24006:SF727 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 42 deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;cysteine-type deubiquitinase activity#GO:0004843;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity, acting on a protein#GO:0140096 regulation of cellular process#GO:0050794;regulation of biological quality#GO:0065008;biological regulation#GO:0065007;regulation of programmed cell death#GO:0043067;regulation of apoptotic process#GO:0042981;regulation of protein stability#GO:0031647;regulation of biological process#GO:0050789 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;cytosol#GO:0005829 cysteine protease#PC00081;protease#PC00190 HUMAN|HGNC=24991|UniProtKB=Q9UNZ5 Q9UNZ5 C19orf53 PTHR16967:SF1 LEYDIG CELL TUMOR 10 KDA PROTEIN HOMOLOG LEYDIG CELL TUMOR 10 KDA PROTEIN HOMOLOG regulation of cell population proliferation#GO:0042127;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;positive regulation of cell population proliferation#GO:0008284;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789 HUMAN|HGNC=2492|UniProtKB=O75638 O75638 CTAG2 PTHR31283:SF15 EKC/KEOPS COMPLEX SUBUNIT PCC1 FAMILY MEMBER CANCER_TESTIS ANTIGEN 2 transferase complex#GO:1990234;catalytic complex#GO:1902494;protein-containing complex#GO:0032991 HUMAN|HGNC=29816|UniProtKB=Q9UH90 Q9UH90 FBXO40 PTHR15933:SF1 PROTEIN CBG16327 F-BOX ONLY PROTEIN 40 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=30228|UniProtKB=Q4J6C6 Q4J6C6 PREPL PTHR11757:SF23 PROTEASE FAMILY S9A OLIGOPEPTIDASE PROLYL ENDOPEPTIDASE-LIKE intracellular protein localization#GO:0008104;endosomal transport#GO:0016197;vesicle-mediated transport to the plasma membrane#GO:0098876;establishment of localization#GO:0051234;Golgi vesicle transport#GO:0048193;transport#GO:0006810;protein localization to cell periphery#GO:1990778;intracellular transport#GO:0046907;vesicle-mediated transport#GO:0016192;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule localization#GO:0033036;establishment of protein localization to membrane#GO:0090150;retrograde transport, endosome to Golgi#GO:0042147;post-Golgi vesicle-mediated transport#GO:0006892;protein transport#GO:0015031;localization#GO:0051179;cellular localization#GO:0051641;establishment of protein localization to plasma membrane#GO:0061951;localization within membrane#GO:0051668;cytosolic transport#GO:0016482;Golgi to plasma membrane protein transport#GO:0043001;Golgi to plasma membrane transport#GO:0006893;protein localization to membrane#GO:0072657;protein localization to plasma membrane#GO:0072659 membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 serine protease#PC00203 Vasopressin synthesis#P04395>Endo Peptidase#P04596 HUMAN|HGNC=25834|UniProtKB=Q9H8G2 Q9H8G2 CAAP1 PTHR14740:SF3 CASPASE ACTIVITY AND APOPTOSIS INHIBITOR 1 CASPASE ACTIVITY AND APOPTOSIS INHIBITOR 1 HUMAN|HGNC=25546|UniProtKB=Q9NVR7 Q9NVR7 TBCCD1 PTHR16052:SF4 TBCC DOMAIN-CONTAINING PROTEIN 1 TBCC DOMAIN-CONTAINING PROTEIN 1 centrosome localization#GO:0051642;localization#GO:0051179;cellular localization#GO:0051641;cellular process#GO:0009987;organelle localization#GO:0051640 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;centrosome#GO:0005813;microtubule organizing center#GO:0005815;spindle#GO:0005819;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;spindle pole#GO:0000922;microtubule cytoskeleton#GO:0015630 HUMAN|HGNC=14272|UniProtKB=Q8IUH2 Q8IUH2 CREG2 PTHR13343:SF15 CREG1 PROTEIN PROTEIN CREG2 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=15862|UniProtKB=Q9NWM0 Q9NWM0 SMOX PTHR10742:SF416 FLAVIN MONOAMINE OXIDASE SPERMINE OXIDASE catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 amine metabolic process#GO:0009308;polyamine metabolic process#GO:0006595;cellular process#GO:0009987;catabolic process#GO:0009056;biogenic amine metabolic process#GO:0006576;metabolic process#GO:0008152;polyamine catabolic process#GO:0006598;amine catabolic process#GO:0009310 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 oxidase#PC00175 HUMAN|HGNC=26559|UniProtKB=Q5T4F4 Q5T4F4 ZFYVE27 PTHR14543:SF1 PROTRUDIN PROTRUDIN regulation of cell projection organization#GO:0031344;regulation of cell differentiation#GO:0045595;transport#GO:0006810;positive regulation of developmental process#GO:0051094;regulation of plasma membrane bounded cell projection organization#GO:0120035;neurogenesis#GO:0022008;regulation of cell development#GO:0060284;positive regulation of cellular process#GO:0048522;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;positive regulation of cell projection organization#GO:0031346;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;localization within membrane#GO:0051668;anatomical structure development#GO:0048856;regulation of neurogenesis#GO:0050767;protein localization to plasma membrane#GO:0072659;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;endoplasmic reticulum tubular network organization#GO:0071786;response to growth factor#GO:0070848;protein localization to cell periphery#GO:1990778;regulation of anatomical structure size#GO:0090066;positive regulation of cell differentiation#GO:0045597;neuron differentiation#GO:0030182;positive regulation of cell growth#GO:0030307;regulation of anatomical structure morphogenesis#GO:0022603;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cellular component biogenesis#GO:0044085;neuron projection development#GO:0031175;organelle organization#GO:0006996;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;regulation of neuron projection development#GO:0010975;vesicle-mediated transport#GO:0016192;positive regulation of cell development#GO:0010720;nervous system development#GO:0007399;endomembrane system organization#GO:0010256;animal gross anatomical part developmental process#GO:0160108;cellular localization#GO:0051641;neuron development#GO:0048666;regulation of biological quality#GO:0065008;positive regulation of multicellular organismal process#GO:0051240;endoplasmic reticulum organization#GO:0007029;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of cellular component organization#GO:0051128;cell development#GO:0048468;developmental process#GO:0032502;establishment of localization#GO:0051234;cellular developmental process#GO:0048869;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;plasma membrane bounded cell projection organization#GO:0120036;regulation of nervous system development#GO:0051960;enzyme-linked receptor protein signaling pathway#GO:0007167;localization#GO:0051179;cell communication#GO:0007154;system development#GO:0048731;regulation of growth#GO:0040008;positive regulation of neurogenesis#GO:0050769;regulation of developmental process#GO:0050793;cell surface receptor signaling pathway#GO:0007166;regulation of axonogenesis#GO:0050770;regulation of cell growth#GO:0001558;cellular component assembly#GO:0022607;regulation of multicellular organismal process#GO:0051239;positive regulation of growth#GO:0045927;positive regulation of cellular component organization#GO:0051130;generation of neurons#GO:0048699;regulation of cell size#GO:0008361;positive regulation of axonogenesis#GO:0050772;cellular response to growth factor stimulus#GO:0071363;cellular component organization#GO:0016043;protein localization to membrane#GO:0072657;response to endogenous stimulus#GO:0009719;regulation of multicellular organismal development#GO:2000026;regulation of cellular component size#GO:0032535;cell differentiation#GO:0030154;cellular response to endogenous stimulus#GO:0071495;positive regulation of nervous system development#GO:0051962;cell projection organization#GO:0030030;signaling#GO:0023052 intracellular anatomical structure#GO:0005622;site of polarized growth#GO:0030427;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;growth cone#GO:0030426;endoplasmic reticulum subcompartment#GO:0098827;axon#GO:0030424;intracellular organelle#GO:0043229;plasma membrane bounded cell projection#GO:0120025;distal axon#GO:0150034;intracellular membrane-bounded organelle#GO:0043231;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;cytoplasm#GO:0005737;plasma membrane#GO:0005886;endomembrane system#GO:0012505;cell periphery#GO:0071944;endoplasmic reticulum tubular network#GO:0071782;neuron projection#GO:0043005;membrane#GO:0016020 membrane trafficking regulatory protein#PC00151;membrane traffic protein#PC00150 HUMAN|HGNC=9580|UniProtKB=O43586 O43586 PSTPIP1 PTHR23065:SF51 PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1 PROLINE-SERINE-THREONINE PHOSPHATASE-INTERACTING PROTEIN 1 plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 actin or actin-binding cytoskeletal protein#PC00041;cytoskeletal protein#PC00085 HUMAN|HGNC=10767|UniProtKB=Q12874 Q12874 SF3A3 PTHR12786:SF3 SPLICING FACTOR SF3A-RELATED SPLICING FACTOR 3A SUBUNIT 3 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;snoRNA binding#GO:0030515 macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;gene expression#GO:0010467;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;mRNA cis splicing, via spliceosome#GO:0045292;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398 nucleus#GO:0005634;spliceosomal complex#GO:0005681;small nuclear ribonucleoprotein complex#GO:0030532;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;U2 snRNP#GO:0005686;ribonucleoprotein complex#GO:1990904;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;spliceosomal snRNP complex#GO:0097525;nuclear protein-containing complex#GO:0140513;Sm-like protein family complex#GO:0120114 RNA splicing factor#PC00148 HUMAN|HGNC=28953|UniProtKB=Q15040 Q15040 JOSD1 PTHR13291:SF1 JOSEPHIN 1, 2 JOSEPHIN-1 cysteine-type peptidase activity#GO:0008234;cysteine-type deubiquitinase activity#GO:0004843;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787 protein modifying enzyme#PC00260;cysteine protease#PC00081 HUMAN|HGNC=6714|UniProtKB=Q14766 Q14766 LTBP1 PTHR24034:SF140 EGF-LIKE DOMAIN-CONTAINING PROTEIN LATENT-TRANSFORMING GROWTH FACTOR BETA-BINDING PROTEIN 1 extracellular matrix binding#GO:0050840;binding#GO:0005488 extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cellular anatomical structure#GO:0110165 extracellular matrix structural protein#PC00103;extracellular matrix protein#PC00102 HUMAN|HGNC=4245|UniProtKB=O60609 O60609 GFRA3 PTHR10269:SF15 GDNF RECEPTOR ALPHA GDNF FAMILY RECEPTOR ALPHA-3 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 system development#GO:0048731;nervous system development#GO:0007399;multicellular organism development#GO:0007275;anatomical structure development#GO:0048856;multicellular organismal process#GO:0032501;developmental process#GO:0032502;animal gross anatomical part developmental process#GO:0160108 external side of plasma membrane#GO:0009897;signaling receptor complex#GO:0043235;side of membrane#GO:0098552;membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cell surface#GO:0009986;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=18274|UniProtKB=Q9NS75 Q9NS75 CYSLTR2 PTHR24230:SF10 G-PROTEIN COUPLED RECEPTOR CYSTEINYL LEUKOTRIENE RECEPTOR 2 neuropeptide receptor activity#GO:0008188;transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;neuropeptide signaling pathway#GO:0007218;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021 HUMAN|HGNC=10955|UniProtKB=Q92959 Q92959 SLCO2A1 PTHR11388:SF14 ORGANIC ANION TRANSPORTER SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 2A1 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;secondary active transmembrane transporter activity#GO:0015291;active transmembrane transporter activity#GO:0022804 lipid transport#GO:0006869;cellular process#GO:0009987;macromolecule localization#GO:0033036;monocarboxylic acid transport#GO:0015718;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;fatty acid transport#GO:0015908;carboxylic acid transport#GO:0046942;organic acid transport#GO:0015849;transport#GO:0006810;lipid localization#GO:0010876 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;cell periphery#GO:0071944;basal plasma membrane#GO:0009925;membrane#GO:0016020;basolateral plasma membrane#GO:0016323;basal part of cell#GO:0045178 transporter#PC00227 HUMAN|HGNC=3242|UniProtKB=Q9H4M9 Q9H4M9 EHD1 PTHR11216:SF127 EH DOMAIN EH DOMAIN-CONTAINING PROTEIN 1 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 organelle assembly#GO:0070925;localization within membrane#GO:0051668;localization#GO:0051179;cellular localization#GO:0051641;cilium organization#GO:0044782;protein localization to membrane#GO:0072657;cellular component organization#GO:0016043;cilium assembly#GO:0060271;protein localization to plasma membrane#GO:0072659;cell projection organization#GO:0030030;endocytic recycling#GO:0032456;endocytosis#GO:0006897;plasma membrane bounded cell projection assembly#GO:0120031;protein localization to cell periphery#GO:1990778;intracellular transport#GO:0046907;transport#GO:0006810;cellular component organization or biogenesis#GO:0071840;import into cell#GO:0098657;establishment of localization#GO:0051234;endosomal transport#GO:0016197;vesicle-mediated transport to the plasma membrane#GO:0098876;intracellular protein localization#GO:0008104;cellular component biogenesis#GO:0044085;macromolecule localization#GO:0033036;organelle organization#GO:0006996;establishment of localization in cell#GO:0051649;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component assembly#GO:0022607;vesicle-mediated transport#GO:0016192;plasma membrane bounded cell projection organization#GO:0120036 cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;endocytic vesicle#GO:0030139;endosome#GO:0005768;endosome membrane#GO:0010008;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular vesicle#GO:0097708;organelle membrane#GO:0031090;recycling endosome membrane#GO:0055038;bounding membrane of organelle#GO:0098588;recycling endosome#GO:0055037;cytoplasm#GO:0005737;plasma membrane#GO:0005886;perinuclear region of cytoplasm#GO:0048471;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;cell periphery#GO:0071944;membrane#GO:0016020;vesicle membrane#GO:0012506 membrane traffic protein#PC00150 HUMAN|HGNC=14726|UniProtKB=Q8NGD4 Q8NGD4 OR4K1 PTHR48002:SF9 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 4K1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=4170|UniProtKB=P15976 P15976 GATA1 PTHR10071:SF190 TRANSCRIPTION FACTOR GATA FAMILY MEMBER ERYTHROID TRANSCRIPTION FACTOR DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;cell fate commitment#GO:0045165;negative regulation of DNA-templated transcription#GO:0045892;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;negative regulation of metabolic process#GO:0009892;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 DNA-binding transcription factor#PC00218 HUMAN|HGNC=9015|UniProtKB=Q9NTG1 Q9NTG1 PKDREJ PTHR10877:SF185 POLYCYSTIN FAMILY MEMBER POLYCYSTIN FAMILY RECEPTOR FOR EGG JELLY calcium ion transmembrane transporter activity#GO:0015085;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261;metal ion transmembrane transporter activity#GO:0046873;passive transmembrane transporter activity#GO:0022803;calcium channel activity#GO:0005262;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 detection of mechanical stimulus#GO:0050982;response to abiotic stimulus#GO:0009628;detection of stimulus#GO:0051606;response to mechanical stimulus#GO:0009612;response to stimulus#GO:0050896;response to external stimulus#GO:0009605 cellular anatomical structure#GO:0110165;membrane#GO:0016020 ion channel#PC00133 HUMAN|HGNC=9449|UniProtKB=P04156 P04156 PRNP PTHR15506:SF2 DOPPEL PRION MAJOR PRION PROTEIN transition metal ion binding#GO:0046914;ion binding#GO:0043167;protein-macromolecule adaptor activity#GO:0030674;binding#GO:0005488;small molecule binding#GO:0036094;cation binding#GO:0043169;molecular condensate scaffold activity#GO:0140693;metal ion binding#GO:0046872;molecular adaptor activity#GO:0060090;copper ion binding#GO:0005507 regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;response to metal ion#GO:0010038;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;response to chemical#GO:0042221;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;positive regulation of calcium-mediated signaling#GO:0050850;regulation of intracellular signal transduction#GO:1902531;cellular response to chemical stimulus#GO:0070887;regulation of cell communication#GO:0010646;regulation of calcium-mediated signaling#GO:0050848;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967 membrane raft#GO:0045121;membrane#GO:0016020;membrane microdomain#GO:0098857;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HUMAN|HGNC=25816|UniProtKB=Q9H8M9 Q9H8M9 EVA1A PTHR46780:SF22 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG A HUMAN|HGNC=19742|UniProtKB=Q96L50 Q96L50 LRR1 PTHR45752:SF153 LEUCINE-RICH REPEAT-CONTAINING LEUCINE-RICH REPEAT PROTEIN 1 scaffold/adaptor protein#PC00226 HUMAN|HGNC=11003|UniProtKB=Q99808 Q99808 SLC29A1 PTHR10332:SF9 EQUILIBRATIVE NUCLEOSIDE TRANSPORTER EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1 carbohydrate derivative transmembrane transporter activity#GO:1901505;nucleobase-containing compound transmembrane transporter activity#GO:0015932;nucleoside transmembrane transporter activity#GO:0005337;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;transport#GO:0006810;nucleobase-containing compound transport#GO:0015931;cellular process#GO:0009987;carbohydrate derivative transport#GO:1901264;nitrogen compound transport#GO:0071705 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227 HUMAN|HGNC=233|UniProtKB=Q08462 Q08462 ADCY2 PTHR45627:SF6 ADENYLATE CYCLASE TYPE 1 ADENYLATE CYCLASE TYPE 2 catalytic activity#GO:0003824;cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;lyase activity#GO:0016829;adenylate cyclase activity#GO:0004016 primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;nucleoside phosphate metabolic process#GO:0006753;cell communication#GO:0007154;organophosphate biosynthetic process#GO:0090407;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;carbohydrate derivative metabolic process#GO:1901135;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;cyclic nucleotide metabolic process#GO:0009187;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;nucleoside phosphate biosynthetic process#GO:1901293;phosphorus metabolic process#GO:0006793;purine nucleotide metabolic process#GO:0006163;regulation of biological process#GO:0050789;purine-containing compound metabolic process#GO:0072521;response to stimulus#GO:0050896;small molecule metabolic process#GO:0044281;signaling#GO:0023052;purine-containing compound biosynthetic process#GO:0072522;G protein-coupled receptor signaling pathway#GO:0007186;purine nucleotide biosynthetic process#GO:0006164;ribonucleotide metabolic process#GO:0009259;cyclic nucleotide biosynthetic process#GO:0009190;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;nucleotide biosynthetic process#GO:0009165;ribose phosphate biosynthetic process#GO:0046390;signal transduction#GO:0007165;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing compound biosynthetic process#GO:0034654;cyclic purine nucleotide metabolic process#GO:0052652;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 adenylate cyclase#PC00043 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>cAMP cyclase#P00719;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>AC#P00841;Beta2 adrenergic receptor signaling pathway#P04378>AC#P04446;Opioid proopiomelanocortin pathway#P05917>AC#P06011;Enkephalin release#P05913>AC#P05978;Nicotine pharmacodynamics pathway#P06587>ADCY2#P06606;5HT1 type receptor mediated signaling pathway#P04373>AC#P04406;Beta1 adrenergic receptor signaling pathway#P04377>AC#P04439;Endothelin signaling pathway#P00019>Adenylate cyclase#P00569;Histamine H2 receptor mediated signaling pathway#P04386>AC#P04492;5HT4 type receptor mediated signaling pathway#P04376>AC#P04429;Opioid proenkephalin pathway#P05915>AC#P05993;Beta3 adrenergic receptor signaling pathway#P04379>AC#P04450;Opioid prodynorphin pathway#P05916>AC#P06001;Dopamine receptor mediated signaling pathway#P05912>AC#P05947;GABA-B receptor II signaling#P05731>AC#P05760 HUMAN|HGNC=8966|UniProtKB=Q9Y2B2 Q9Y2B2 PIGL PTHR12993:SF11 N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE-RELATED N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;deacetylase activity#GO:0019213;hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;catalytic activity#GO:0003824;deacylase activity#GO:0160215 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 deacetylase#PC00087 HUMAN|HGNC=29003|UniProtKB=O15014 O15014 ZNF609 PTHR21564:SF2 BRAKELESS PROTEIN ZINC FINGER PROTEIN 609 regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=20716|UniProtKB=Q9H0B6 Q9H0B6 KLC2 PTHR45783:SF2 KINESIN LIGHT CHAIN KINESIN LIGHT CHAIN 2 binding#GO:0005488;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515 microtubule-based process#GO:0007017;microtubule-based movement#GO:0007018;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 microtubule binding motor protein#PC00156 Alzheimer disease-amyloid secretase pathway#P00003>kinesin#P00107 HUMAN|HGNC=17972|UniProtKB=Q9NPD7 Q9NPD7 NRN1 PTHR15902:SF1 NEURITIN-RELATED NEURITIN cellular process#GO:0009987;neuron projection development#GO:0031175;plasma membrane bounded cell projection organization#GO:0120036;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;developmental process#GO:0032502;neuron differentiation#GO:0030182;neuron projection morphogenesis#GO:0048812;growth#GO:0040007;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell projection morphogenesis#GO:0048858;neurogenesis#GO:0022008;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cell growth#GO:0016049;developmental growth#GO:0048589;cellular developmental process#GO:0048869;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;cell development#GO:0048468;developmental cell growth#GO:0048588;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell morphogenesis#GO:0000902;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;developmental growth involved in morphogenesis#GO:0060560;neuron development#GO:0048666;neuron projection extension#GO:1990138;anatomical structure development#GO:0048856 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HUMAN|HGNC=14872|UniProtKB=Q9BXN1 Q9BXN1 ASPN PTHR45712:SF2 AGAP008170-PA ASPORIN extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=28915|UniProtKB=Q9NR55 Q9NR55 BATF3 PTHR23351:SF13 FOS TRANSCRIPTION FACTOR-RELATED BASIC LEUCINE ZIPPER TRANSCRIPTIONAL FACTOR ATF-LIKE 3 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 basic leucine zipper transcription factor#PC00056 HUMAN|HGNC=8999|UniProtKB=Q9UG56 Q9UG56 PISD PTHR10067:SF6 PHOSPHATIDYLSERINE DECARBOXYLASE PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME, MITOCHONDRIAL carboxy-lyase activity#GO:0016831;catalytic activity#GO:0003824;carbon-carbon lyase activity#GO:0016830;lyase activity#GO:0016829 organophosphate biosynthetic process#GO:0090407;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474;lipid biosynthetic process#GO:0008610;phospholipid biosynthetic process#GO:0008654;glycerolipid metabolic process#GO:0046486;glycerophospholipid metabolic process#GO:0006650;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 metabolite interconversion enzyme#PC00262;lyase#PC00144;decarboxylase#PC00089 HUMAN|HGNC=6602|UniProtKB=O75019 O75019 LILRA1 PTHR11738:SF165 MHC CLASS I NK CELL RECEPTOR LEUKOCYTE IMMUNOGLOBULIN-LIKE RECEPTOR SUBFAMILY A MEMBER 1-RELATED transmembrane signaling receptor activity#GO:0004888;immune receptor activity#GO:0140375;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell surface receptor signaling pathway#GO:0007166;regulation of response to stimulus#GO:0048583;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;response to chemical#GO:0042221;response to cytokine#GO:0034097;cellular process#GO:0009987;signal transduction#GO:0007165;response to peptide#GO:1901652;cell communication#GO:0007154;regulation of immune response#GO:0050776;cytokine-mediated signaling pathway#GO:0019221;signaling#GO:0023052;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;immune response-regulating signaling pathway#GO:0002764;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=4177|UniProtKB=P04062 P04062 GBA1 PTHR11069:SF33 GLUCOSYLCERAMIDASE LYSOSOMAL ACID GLUCOSYLCERAMIDASE hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553 liposaccharide metabolic process#GO:1903509;catabolic process#GO:0009056;glycolipid metabolic process#GO:0006664;carbohydrate derivative catabolic process#GO:1901136;sphingolipid catabolic process#GO:0030149;primary metabolic process#GO:0044238;lipid catabolic process#GO:0016042;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;ceramide metabolic process#GO:0006672;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;lipid metabolic process#GO:0006629 HUMAN|HGNC=37221|UniProtKB=P86479 P86479 PRR20C PTHR38819:SF1 PROLINE-RICH PROTEIN 20A-RELATED PROLINE-RICH PROTEIN 20A-RELATED HUMAN|HGNC=4265|UniProtKB=P01286 P01286 GHRH PTHR11213:SF6 GLUCAGON-FAMILY NEUROPEPTIDE SOMATOLIBERIN protein binding#GO:0005515;hormone activity#GO:0005179;molecular function activator activity#GO:0140677;binding#GO:0005488;signaling receptor binding#GO:0005102;hormone receptor binding#GO:0051427;neuropeptide hormone activity#GO:0005184;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;neuropeptide receptor binding#GO:0071855;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;G protein-coupled receptor binding#GO:0001664 regulation of biological process#GO:0050789;regulation of hormone levels#GO:0010817;export from cell#GO:0140352;signaling#GO:0023052;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;secretion by cell#GO:0032940;regulation of protein localization#GO:0032880;hormone secretion#GO:0046879;regulation of biological quality#GO:0065008;positive regulation of signaling#GO:0023056;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;hormone transport#GO:0009914;regulation of localization#GO:0032879;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;peptide secretion#GO:0002790;signal release#GO:0023061;peptide hormone secretion#GO:0030072;cell communication#GO:0007154;localization#GO:0051179;secretion#GO:0046903;positive regulation of cellular process#GO:0048522;peptide transport#GO:0015833;nitrogen compound transport#GO:0071705;regulation of signal transduction#GO:0009966;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;transport#GO:0006810;establishment of localization#GO:0051234 somatodendritic compartment#GO:0036477;neuron projection#GO:0043005;presynapse#GO:0098793;perikaryon#GO:0043204;axon terminus#GO:0043679;cell junction#GO:0030054;neuronal cell body#GO:0043025;neuron projection terminus#GO:0044306;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;terminal bouton#GO:0043195;distal axon#GO:0150034;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell body#GO:0044297;axon#GO:0030424;extracellular region#GO:0005576 neuropeptide#PC00162 HUMAN|HGNC=1875|UniProtKB=Q9Y281 Q9Y281 CFL2 PTHR11913:SF15 COFILIN-RELATED COFILIN-2 protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin filament binding#GO:0051015;actin binding#GO:0003779 actin polymerization or depolymerization#GO:0008154;cellular process#GO:0009987;actin filament depolymerization#GO:0030042;cellular component organization#GO:0016043;organelle organization#GO:0006996;protein depolymerization#GO:0051261;protein-containing complex disassembly#GO:0032984;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;actin filament-based process#GO:0030029;protein-containing complex organization#GO:0043933;actin filament organization#GO:0007015;supramolecular fiber organization#GO:0097435;cellular component disassembly#GO:0022411;cellular component organization or biogenesis#GO:0071840 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;actin cytoskeleton#GO:0015629;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232 non-motor actin binding protein#PC00165 Cytoskeletal regulation by Rho GTPase#P00016>Cofilin#P00508 HUMAN|HGNC=10892|UniProtKB=O95475 O95475 SIX6 PTHR10390:SF12 HOMEOBOX PROTEIN SIX HOMEOBOX PROTEIN SIX6 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677 system development#GO:0048731;eye development#GO:0001654;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;animal gross anatomical part developmental process#GO:0160108;visual system development#GO:0150063;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of gene expression#GO:0010468;multicellular organism development#GO:0007275;regulation of biosynthetic process#GO:0009889;animal organ development#GO:0048513;developmental process#GO:0032502;sensory organ development#GO:0007423;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;sensory system development#GO:0048880 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119 HUMAN|HGNC=12027|UniProtKB=P0DTU3 P0DTU3 TRA PTHR19433:SF72 T-CELL RECEPTOR ALPHA CHAIN V REGION-RELATED T CELL RECEPTOR ALPHA CHAIN MC.7.G5-RELATED response to stimulus#GO:0050896;response to external stimulus#GO:0009605;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to other organism#GO:0051707;response to biotic stimulus#GO:0009607;response to bacterium#GO:0009617 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=35463|UniProtKB=A6NLX3 A6NLX3 SPDYE4 PTHR31156:SF11 WBSCR19-LIKE PROTEIN SPEEDY PROTEIN E4 HUMAN|HGNC=11358|UniProtKB=O75886 O75886 STAM2 PTHR45929:SF1 JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE SIGNAL TRANSDUCING ADAPTER MOLECULE 2 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043162;endosome transport via multivesicular body sorting pathway#GO:0032509;biological regulation#GO:0065007;macromolecule localization#GO:0033036;late endosome to vacuole transport via multivesicular body sorting pathway#GO:0032511;multivesicular body sorting pathway#GO:0071985;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;transport#GO:0006810;vacuolar transport#GO:0007034;protein localization to organelle#GO:0033365;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;modification-dependent protein catabolic process#GO:0019941;protein metabolic process#GO:0019538;localization#GO:0051179;cell communication#GO:0007154;protein localization to vacuole#GO:0072665;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;signal transduction#GO:0007165;endosomal transport#GO:0016197;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;intracellular protein transport#GO:0006886;response to stimulus#GO:0050896;establishment of protein localization to vacuole#GO:0072666;protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043328;late endosome to vacuole transport#GO:0045324;signaling#GO:0023052;regulation of biological process#GO:0050789;cellular localization#GO:0051641;protein transport#GO:0015031;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163 intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;endocytic vesicle#GO:0030139;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410 scaffold/adaptor protein#PC00226 HUMAN|HGNC=28246|UniProtKB=Q96ID5 Q96ID5 IGSF21 PTHR23277:SF121 NECTIN-RELATED IMMUNOGLOBULIN SUPERFAMILY MEMBER 21 protein binding#GO:0005515;binding#GO:0005488;cell adhesion mediator activity#GO:0098631;cell adhesion molecule binding#GO:0050839 cell communication#GO:0007154;regulation of signaling#GO:0023051;cell adhesion#GO:0007155;trans-synaptic signaling#GO:0099537;regulation of cell communication#GO:0010646;signaling#GO:0023052;modulation of chemical synaptic transmission#GO:0050804;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;regulation of trans-synaptic signaling#GO:0099177;heterophilic cell-cell adhesion#GO:0007157;cellular process#GO:0009987;synaptic signaling#GO:0099536;cell-cell adhesion#GO:0098609;homophilic cell-cell adhesion#GO:0007156 postsynapse#GO:0098794;asymmetric synapse#GO:0032279;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;postsynaptic density#GO:0014069;postsynaptic density membrane#GO:0098839;anchoring junction#GO:0070161;cell-cell junction#GO:0005911;membrane#GO:0016020;presynapse#GO:0098793;cell periphery#GO:0071944;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;neuron to neuron synapse#GO:0098984;plasma membrane#GO:0005886;presynaptic membrane#GO:0042734;synaptic membrane#GO:0097060;cell junction#GO:0030054;adherens junction#GO:0005912 cell adhesion molecule#PC00069 HUMAN|HGNC=31332|UniProtKB=Q6IQ22 Q6IQ22 RAB12 PTHR47980:SF35 LD44762P RAS-RELATED PROTEIN RAB-12 intracellular transport#GO:0046907;transport#GO:0006810;establishment of localization#GO:0051234;vesicle-mediated transport to the plasma membrane#GO:0098876;endosomal transport#GO:0016197;exocytosis#GO:0006887;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;localization within membrane#GO:0051668;localization#GO:0051179;cellular localization#GO:0051641;secretion#GO:0046903;secretion by cell#GO:0032940;endocytic recycling#GO:0032456;export from cell#GO:0140352 membrane-bounded organelle#GO:0043227;coated vesicle#GO:0030135;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768;trans-Golgi network transport vesicle#GO:0030140;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;Golgi-associated vesicle#GO:0005798;clathrin-coated vesicle#GO:0030136;plasma membrane#GO:0005886;cytoplasm#GO:0005737;transport vesicle#GO:0030133;endomembrane system#GO:0012505;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=19573|UniProtKB=Q8NGZ9 Q8NGZ9 OR2T10 PTHR26453:SF734 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2T10 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;response to chemical#GO:0042221;response to stimulus#GO:0050896;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;detection of chemical stimulus#GO:0009593;system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;nervous system process#GO:0050877;sensory perception#GO:0007600 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=1068|UniProtKB=O95972 O95972 BMP15 PTHR11848:SF22 TGF-BETA FAMILY BONE MORPHOGENETIC PROTEIN 15 cytokine activity#GO:0005125;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772 enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;cell surface receptor signaling pathway#GO:0007166;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 growth factor#PC00112 Gonadotropin-releasing hormone receptor pathway#P06664>BMP2/4/15#P06817;TGF-beta signaling pathway#P00052>TGFbeta#P01286 HUMAN|HGNC=24485|UniProtKB=Q9UFP1 Q9UFP1 GASK1A PTHR15905:SF5 GOLGI-ASSOCIATED KINASE 1B-RELATED GOLGI-ASSOCIATED KINASE 1A intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=29259|UniProtKB=Q7L7X3 Q7L7X3 TAOK1 PTHR47167:SF8 SERINE/THREONINE-PROTEIN KINASE TAO1-LIKE PROTEIN SERINE_THREONINE-PROTEIN KINASE TAO1 protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096 positive regulation of JNK cascade#GO:0046330;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;regulation of cellular response to stress#GO:0080135;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of response to stress#GO:0080134;regulation of MAPK cascade#GO:0043408;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;regulation of JNK cascade#GO:0046328;positive regulation of MAPK cascade#GO:0043410;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of response to stimulus#GO:0048584;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=5747|UniProtKB=A0A0B4J2D9 A0A0B4J2D9 IGKV1D-13 PTHR23267:SF480 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN KAPPA VARIABLE 1-13-RELATED response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 protein-containing complex#GO:0032991 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=17842|UniProtKB=Q9UJY5 Q9UJY5 GGA1 PTHR45905:SF4 GOLGI-LOCALIZED, GAMMA-ADAPTIN EAR CONTAINING, ARF BINDING PROTEIN ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1 binding#GO:0005488;enzyme binding#GO:0019899;protein binding#GO:0005515;small GTPase binding#GO:0031267 vesicle-mediated transport to the plasma membrane#GO:0098876;intracellular protein localization#GO:0008104;post-Golgi vesicle-mediated transport#GO:0006892;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization within membrane#GO:0051668;transport#GO:0006810;Golgi vesicle transport#GO:0048193;Golgi to plasma membrane transport#GO:0006893;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;macromolecule localization#GO:0033036 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus subcompartment#GO:0098791;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 HUMAN|HGNC=24555|UniProtKB=Q8N201 Q8N201 INTS1 PTHR21224:SF1 INTEGRATOR COMPLEX SUBUNIT 1 INTEGRATOR COMPLEX SUBUNIT 1 biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;nucleic acid catabolic process#GO:0141188;nucleobase-containing compound catabolic process#GO:0034655;transcription initiation at RNA polymerase II promoter#GO:0006367;snRNA processing#GO:0016180;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule catabolic process#GO:0009057;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;snRNA 3'-end processing#GO:0034472;catabolic process#GO:0009056;DNA-templated transcription initiation#GO:0006352;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;snRNA metabolic process#GO:0016073;RNA metabolic process#GO:0016070;RNA catabolic process#GO:0006401;nucleic acid biosynthetic process#GO:0141187 integrator complex#GO:0032039;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=28118|UniProtKB=P13994 P13994 YJU2B PTHR12111:SF2 SPLICING FACTOR YJU2 SPLICING FACTOR YJU2B-RELATED protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;U2-type spliceosomal complex#GO:0005684;post-mRNA release spliceosomal complex#GO:0071014;spliceosomal complex#GO:0005681;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229 RNA splicing factor#PC00148 HUMAN|HGNC=5797|UniProtKB=A0A075B6R9 A0A075B6R9 IGKV2D-24 PTHR23267:SF379 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN KAPPA VARIABLE 2-24-RELATED immune system process#GO:0002376;immune response#GO:0006955;response to stimulus#GO:0050896 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=1510|UniProtKB=Q9UKL3 Q9UKL3 CASP8AP2 PTHR15489:SF2 CASPASE 8 ASSOCIATED PROTEIN 2 CASP8-ASSOCIATED PROTEIN 2 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714 signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;cell surface receptor signaling pathway#GO:0007166;apoptotic signaling pathway#GO:0097190;extrinsic apoptotic signaling pathway via death domain receptors#GO:0008625;regulation of biological process#GO:0050789;cell death#GO:0008219;apoptotic process#GO:0006915;cellular response to stimulus#GO:0051716;programmed cell death#GO:0012501;signaling#GO:0023052;response to stimulus#GO:0050896;extrinsic apoptotic signaling pathway#GO:0097191;regulation of cellular process#GO:0050794;cell communication#GO:0007154 mitochondrion#GO:0005739;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;PML body#GO:0016605;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;nuclear body#GO:0016604;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228 protein-binding activity modulator#PC00095 HUMAN|HGNC=17814|UniProtKB=Q8IX21 Q8IX21 SLF2 PTHR16046:SF10 SMC5-SMC6 COMPLEX LOCALIZATION FACTOR 2 SMC5-SMC6 COMPLEX LOCALIZATION FACTOR PROTEIN 2 macromolecule localization#GO:0033036;regulation of primary metabolic process#GO:0080090;response to stress#GO:0006950;regulation of metabolic process#GO:0019222;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of response to stimulus#GO:0048584;positive regulation of macromolecule metabolic process#GO:0010604;biological regulation#GO:0065007;positive regulation of DNA repair#GO:0045739;regulation of response to stress#GO:0080134;DNA damage response#GO:0006974;regulation of response to stimulus#GO:0048583;regulation of DNA repair#GO:0006282;intracellular protein localization#GO:0008104;positive regulation of DNA metabolic process#GO:0051054;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;regulation of DNA metabolic process#GO:0051052;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;protein localization to organelle#GO:0033365;positive regulation of double-strand break repair#GO:2000781;cellular response to stress#GO:0033554;positive regulation of metabolic process#GO:0009893;localization#GO:0051179;regulation of double-strand break repair#GO:2000779;regulation of cellular response to stress#GO:0080135 chromosome#GO:0005694;site of double-strand break#GO:0035861;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;site of DNA damage#GO:0090734 HUMAN|HGNC=19965|UniProtKB=Q9P2K2 Q9P2K2 TXNDC16 PTHR22699:SF1 THIOREDOXIN DOMAIN-CONTAINING PROTEIN 16 THIOREDOXIN DOMAIN-CONTAINING PROTEIN 16 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=28952|UniProtKB=P42695 P42695 NCAPD3 PTHR14222:SF1 CONDENSIN CONDENSIN-2 COMPLEX SUBUNIT D3 protein binding#GO:0005515;binding#GO:0005488;histone binding#GO:0042393 chromosome condensation#GO:0030261;mitotic chromosome condensation#GO:0007076;organelle fission#GO:0048285;sexual reproduction#GO:0019953;nuclear division#GO:0000280;reproductive process#GO:0022414;mitotic cell cycle#GO:0000278;cell cycle process#GO:0022402;mitotic nuclear division#GO:0140014;cellular component organization#GO:0016043;sister chromatid segregation#GO:0000819;meiotic cell cycle process#GO:1903046;nuclear chromosome segregation#GO:0098813;cell cycle#GO:0007049;chromosome organization#GO:0051276;mitotic cell cycle process#GO:1903047;cellular component organization or biogenesis#GO:0071840;chromosome segregation#GO:0007059;chromosome organization involved in meiotic cell cycle#GO:0070192;meiotic cell cycle#GO:0051321;cellular process#GO:0009987;mitotic sister chromatid segregation#GO:0000070;organelle organization#GO:0006996 organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694;condensed chromosome, centromeric region#GO:0000779;membraneless organelle#GO:0043228;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;condensed chromosome#GO:0000793;chromosome, centromeric region#GO:0000775;intracellular organelle#GO:0043229;condensin complex#GO:0000796 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=2436|UniProtKB=P32927 P32927 CSF2RB PTHR23037:SF22 CYTOKINE RECEPTOR CYTOKINE RECEPTOR COMMON SUBUNIT BETA cytokine receptor activity#GO:0004896;coreceptor activity#GO:0015026;transmembrane signaling receptor activity#GO:0004888;immune receptor activity#GO:0140375;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 positive regulation of cell population proliferation#GO:0008284;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;cytokine-mediated signaling pathway#GO:0019221;immune system process#GO:0002376;regulation of cell population proliferation#GO:0042127;cell communication#GO:0007154;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;immunoglobulin mediated immune response#GO:0016064;response to peptide#GO:1901652;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;signal transduction#GO:0007165;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;immune response#GO:0006955;cellular process#GO:0009987;response to chemical#GO:0042221;response to cytokine#GO:0034097;biological regulation#GO:0065007;adaptive immune response#GO:0002250;cell surface receptor signaling pathway via STAT#GO:0097696;positive regulation of leukocyte proliferation#GO:0070665;cell surface receptor signaling pathway via JAK-STAT#GO:0007259;cell surface receptor signaling pathway#GO:0007166;immune effector process#GO:0002252;regulation of leukocyte proliferation#GO:0070663 external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552 transmembrane signal receptor#PC00197 Interleukin signaling pathway#P00036>Receptor subunit beta#P00974 HUMAN|HGNC=30227|UniProtKB=Q8TCT8 Q8TCT8 SPPL2A PTHR12174:SF34 SIGNAL PEPTIDE PEPTIDASE SIGNAL PEPTIDE PEPTIDASE-LIKE 2A hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity#GO:0003824;aspartic-type endopeptidase activity#GO:0004190 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;metabolic process#GO:0008152;proteolysis#GO:0006508;cellular process#GO:0009987;membrane protein proteolysis#GO:0033619 lysosome#GO:0005764;intracellular vesicle#GO:0097708;lytic vacuole membrane#GO:0098852;Golgi-associated vesicle membrane#GO:0030660;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;organelle subcompartment#GO:0031984;side of membrane#GO:0098552;lysosomal membrane#GO:0005765;vacuole#GO:0005773;cytoplasm#GO:0005737;cytoplasmic side of endoplasmic reticulum membrane#GO:0098554;cytoplasmic vesicle membrane#GO:0030659;endoplasmic reticulum#GO:0005783;cytoplasmic side of membrane#GO:0098562;bounding membrane of organelle#GO:0098588;lytic vacuole#GO:0000323;vesicle#GO:0031982;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum subcompartment#GO:0098827;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;vesicle membrane#GO:0012506;membrane#GO:0016020;endomembrane system#GO:0012505;Golgi-associated vesicle#GO:0005798;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;vacuolar membrane#GO:0005774 aspartic protease#PC00053;protein modifying enzyme#PC00260 HUMAN|HGNC=39080|UniProtKB=B7U540 B7U540 KCNJ18 PTHR11767:SF14 INWARD RECTIFIER POTASSIUM CHANNEL ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 12-RELATED metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation channel activity#GO:0005261;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;potassium channel activity#GO:0005267;ligand-gated monoatomic ion channel activity#GO:0015276 monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;import across plasma membrane#GO:0098739;metal ion transport#GO:0030001;inorganic ion import across plasma membrane#GO:0099587;transport#GO:0006810;potassium ion import across plasma membrane#GO:1990573;establishment of localization#GO:0051234;import into cell#GO:0098657;inorganic cation import across plasma membrane#GO:0098659;cellular process#GO:0009987;potassium ion transport#GO:0006813;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 ion channel#PC00133 HUMAN|HGNC=11460|UniProtKB=P51687 P51687 SUOX PTHR19372:SF7 SULFITE REDUCTASE SULFITE OXIDASE, MITOCHONDRIAL membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739 oxidoreductase#PC00176;reductase#PC00198;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=12570|UniProtKB=Q86WB7 Q86WB7 UNC93A PTHR19444:SF13 UNC-93 RELATED N-ACETYLGLUCOSAMINE TRANSPORTER UNC93A ion channel regulator activity#GO:0099106;transporter regulator activity#GO:0141108;molecular function regulator activity#GO:0098772;channel regulator activity#GO:0016247 inorganic ion homeostasis#GO:0098771;chemical homeostasis#GO:0048878;homeostatic process#GO:0042592 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 membrane-bound signaling molecule#PC00152 HUMAN|HGNC=14377|UniProtKB=Q9NX24 Q9NX24 NHP2 PTHR23105:SF129 RIBOSOMAL PROTEIN L7AE FAMILY MEMBER H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 2 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;snoRNA binding#GO:0030515;binding#GO:0005488 rRNA processing#GO:0006364;snRNA metabolic process#GO:0016073;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;pseudouridine synthesis#GO:0001522;rRNA modification#GO:0000154;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;snRNA processing#GO:0016180;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085 organelle lumen#GO:0043233;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nucleolus#GO:0005730;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;sno(s)RNA-containing ribonucleoprotein complex#GO:0005732;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513 translational protein#PC00263;ribosomal protein#PC00202 HUMAN|HGNC=3148|UniProtKB=P19971 P19971 TYMP PTHR10515:SF0 THYMIDINE PHOSPHORYLASE THYMIDINE PHOSPHORYLASE catalytic activity#GO:0003824;transferase activity#GO:0016740;pentosyltransferase activity#GO:0016763;glycosyltransferase activity#GO:0016757 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 glycosyltransferase#PC00111 Salvage pyrimidine deoxyribonucleotides#P02774>Uracil phosphorylase#P03145;Pyrimidine Metabolism#P02771>Nucleoside Phosphorylase#P03126;Salvage pyrimidine deoxyribonucleotides#P02774>Thymidine phosphorylase#P03148 HUMAN|HGNC=29925|UniProtKB=Q13823 Q13823 GNL2 PTHR11089:SF9 GTP-BINDING PROTEIN-RELATED NUCLEOLAR GTP-BINDING PROTEIN 2 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634 HUMAN|HGNC=17340|UniProtKB=Q6P2Q9 Q6P2Q9 PRPF8 PTHR11140:SF0 PRE-MRNA SPLICING FACTOR PRP8 PRE-MRNA-PROCESSING-SPLICING FACTOR 8 protein complex scaffold activity#GO:0140378;structural molecule activity#GO:0005198 gene expression#GO:0010467;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;mRNA cis splicing, via spliceosome#GO:0045292;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;spliceosomal complex#GO:0005681;spliceosomal snRNP complex#GO:0097525;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;small nuclear ribonucleoprotein complex#GO:0030532;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;catalytic step 2 spliceosome#GO:0071013;U5 snRNP#GO:0005682;Sm-like protein family complex#GO:0120114 RNA splicing factor#PC00148 HUMAN|HGNC=31653|UniProtKB=Q5VZQ5 Q5VZQ5 TEX36 PTHR35440:SF1 TESTIS-EXPRESSED PROTEIN 36 TESTIS-EXPRESSED PROTEIN 36 HUMAN|HGNC=16193|UniProtKB=Q96MM6 Q96MM6 HSPA12B PTHR14187:SF39 ALPHA KINASE/ELONGATION FACTOR 2 KINASE HEAT SHOCK 70 KDA PROTEIN 12B HUMAN|HGNC=29073|UniProtKB=Q8IYA2 Q8IYA2 CCDC144CP PTHR22245:SF3 COILED-COIL DOMAIN-CONTAINING PROTEIN 144A-RELATED COILED-COIL DOMAIN-CONTAINING PROTEIN 144A-RELATED HUMAN|HGNC=6002|UniProtKB=Q9NYY1 Q9NYY1 IL20 PTHR48482:SF2 INTERLEUKIN-19-RELATED INTERLEUKIN-20 molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;signaling receptor regulator activity#GO:0030545;cytokine activity#GO:0005125;receptor ligand activity#GO:0048018 immune system process#GO:0002376;immune response#GO:0006955;response to stimulus#GO:0050896 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=29661|UniProtKB=Q96E52 Q96E52 OMA1 PTHR22726:SF1 METALLOENDOPEPTIDASE OMA1 METALLOENDOPEPTIDASE OMA1, MITOCHONDRIAL endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 cellular process#GO:0009987;primary metabolic process#GO:0044238;catabolic process#GO:0009056;protein quality control for misfolded or incompletely synthesized proteins#GO:0006515;protein catabolic process#GO:0030163;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739 protease#PC00190;metalloprotease#PC00153;protein modifying enzyme#PC00260 HUMAN|HGNC=6796|UniProtKB=P43355 P43355 MAGEA1 PTHR11736:SF49 MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN MELANOMA-ASSOCIATED ANTIGEN 1 protein binding#GO:0005515;histone deacetylase binding#GO:0042826;binding#GO:0005488;enzyme binding#GO:0019899 regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;negative regulation of metabolic process#GO:0009892;negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=4213|UniProtKB=Q96MZ0 Q96MZ0 GDAP1L1 PTHR44188:SF2 GDAP1, ISOFORM A GANGLIOSIDE-INDUCED DIFFERENTIATION-ASSOCIATED PROTEIN 1-LIKE 1 cellular component organization#GO:0016043;organelle organization#GO:0006996;mitochondrial fusion#GO:0008053;cellular process#GO:0009987;mitochondrial fission#GO:0000266;organelle fusion#GO:0048284;mitochondrion organization#GO:0007005;organelle fission#GO:0048285;cellular component organization or biogenesis#GO:0071840 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;outer membrane#GO:0019867;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;mitochondrion#GO:0005739;mitochondrial outer membrane#GO:0005741;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;organelle outer membrane#GO:0031968;cytoplasm#GO:0005737;membrane#GO:0016020;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740 HUMAN|HGNC=7600|UniProtKB=O00160 O00160 MYO1F PTHR13140:SF663 MYOSIN UNCONVENTIONAL MYOSIN-IF macromolecular conformation isomerase activity#GO:0120543;ATP-dependent activity#GO:0140657;polypeptide conformation or assembly isomerase activity#GO:0120544;catalytic activity#GO:0003824;microfilament motor activity#GO:0000146;isomerase activity#GO:0016853;cytoskeletal motor activity#GO:0003774 actin cytoskeleton organization#GO:0030036;endocytosis#GO:0006897;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;localization#GO:0051179;import into cell#GO:0098657;establishment of localization#GO:0051234;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;transport#GO:0006810;actin filament-based process#GO:0030029 cytoplasm#GO:0005737;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;cell periphery#GO:0071944;membrane#GO:0016020;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;microvillus#GO:0005902;actin-based cell projection#GO:0098858;actin cytoskeleton#GO:0015629;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 actin binding motor protein#PC00040 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HUMAN|HGNC=30889|UniProtKB=Q96IX5 Q96IX5 ATP5MK PTHR34038:SF1 ATP SYNTHASE MEMBRANE SUBUNIT DAPIT, MITOCHONDRIAL ATP SYNTHASE F(0) COMPLEX SUBUNIT K, MITOCHONDRIAL proton-transporting two-sector ATPase complex#GO:0016469;catalytic complex#GO:1902494;cation channel complex#GO:0034703;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;respiratory chain complex#GO:0098803;membrane#GO:0016020;membrane protein complex#GO:0098796;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;proton-transporting ATP synthase complex#GO:0045259 ATP synthase#PC00002 HUMAN|HGNC=25828|UniProtKB=A5PLN9 A5PLN9 TRAPPC13 PTHR13134:SF3 TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 13 TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 13 intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;vesicle tethering complex#GO:0099023;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;TRAPP complex#GO:0030008 HUMAN|HGNC=25716|UniProtKB=Q96BR5 Q96BR5 COA7 PTHR13891:SF1 CYTOCHROME C OXIDASE ASSEMBLY FACTOR 7 CYTOCHROME C OXIDASE ASSEMBLY FACTOR 7 disulfide oxidoreductase activity#GO:0015036;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491;protein-disulfide reductase activity#GO:0015035;catalytic activity#GO:0003824;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667 cytochrome complex assembly#GO:0017004;protein-containing complex organization#GO:0043933;respiratory chain complex IV assembly#GO:0008535;cellular component organization or biogenesis#GO:0071840;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;cellular component assembly#GO:0022607 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;mitochondrial intermembrane space#GO:0005758;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrial envelope#GO:0005740;mitochondrion#GO:0005739;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;organelle envelope#GO:0031967 HUMAN|HGNC=28154|UniProtKB=Q9BRJ7 Q9BRJ7 NUDT16L1 PTHR31699:SF6 NUDIX T16 FAMILY MEMBER TUDOR-INTERACTING REPAIR REGULATOR PROTEIN nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723;hydrolase activity#GO:0016787;nuclease activity#GO:0004518;catalytic activity, acting on a nucleic acid#GO:0140640;snoRNA binding#GO:0030515;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;RNA nuclease activity#GO:0004540;endonuclease activity#GO:0004519;catalytic activity, acting on RNA#GO:0140098;RNA endonuclease activity#GO:0004521 negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;mRNA catabolic process#GO:0006402;nucleobase-containing compound catabolic process#GO:0034655;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid catabolic process#GO:0141188;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulation of gene expression#GO:0010468;macromolecule catabolic process#GO:0009057;negative regulation of cellular process#GO:0048523;metabolic process#GO:0008152;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;negative regulation of gene expression#GO:0010629;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;RNA metabolic process#GO:0016070;RNA catabolic process#GO:0006401 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=15034|UniProtKB=Q8NGY5 Q8NGY5 OR6N1 PTHR26453:SF697 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 6N1 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 response to chemical#GO:0042221;response to stimulus#GO:0050896;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;detection of chemical stimulus#GO:0009593;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;system process#GO:0003008;sensory perception#GO:0007600;nervous system process#GO:0050877;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=31921|UniProtKB=Q3KQZ1 Q3KQZ1 SLC25A35 PTHR45928:SF2 RE38146P SOLUTE CARRIER FAMILY 25 MEMBER 35 HUMAN|HGNC=25852|UniProtKB=Q5T089 Q5T089 MORN1 PTHR23084:SF263 PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE RELATED MORN REPEAT-CONTAINING PROTEIN 1 transferase#PC00220;kinase#PC00137 HUMAN|HGNC=5145|UniProtKB=P37235 P37235 HPCAL1 PTHR23055:SF79 CALCIUM BINDING PROTEINS HIPPOCALCIN-LIKE PROTEIN 1 metal ion binding#GO:0046872;cation binding#GO:0043169;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;calcium ion binding#GO:0005509 calmodulin-related#PC00061 HUMAN|HGNC=1685|UniProtKB=P06127 P06127 CD5 PTHR47309:SF1 T-CELL SURFACE GLYCOPROTEIN CD5 T-CELL SURFACE GLYCOPROTEIN CD5 positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of immune system process#GO:0002684;positive regulation of cell-cell adhesion#GO:0022409;regulation of multicellular organismal process#GO:0051239;positive regulation of cell activation#GO:0050867;biological regulation#GO:0065007;positive regulation of leukocyte cell-cell adhesion#GO:1903039;regulation of T cell activation#GO:0050863;regulation of cell adhesion#GO:0030155;positive regulation of T cell activation#GO:0050870;positive regulation of leukocyte activation#GO:0002696;regulation of leukocyte cell-cell adhesion#GO:1903037;regulation of cell activation#GO:0050865;positive regulation of cell adhesion#GO:0045785;positive regulation of multicellular organismal process#GO:0051240;regulation of biological process#GO:0050789;regulation of leukocyte activation#GO:0002694;regulation of lymphocyte activation#GO:0051249;regulation of immune system process#GO:0002682;regulation of cell-cell adhesion#GO:0022407;regulation of cellular process#GO:0050794;immune system process#GO:0002376;positive regulation of lymphocyte activation#GO:0051251 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=26221|UniProtKB=Q9H607 Q9H607 OCEL1 PTHR23288:SF15 OCCLUDIN AND RNA POLYMERASE II ELONGATION FACTOR ELL OCCLUDIN_ELL DOMAIN-CONTAINING PROTEIN 1 cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 positive regulation of macromolecule metabolic process#GO:0010604;cellular component assembly#GO:0022607;gene expression#GO:0010467;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;cellular component organization or biogenesis#GO:0071840;cell-cell junction assembly#GO:0007043;positive regulation of transcription by RNA polymerase II#GO:0045944;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;snRNA transcription#GO:0009301;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of DNA-templated transcription, elongation#GO:0032786;regulation of biological process#GO:0050789;cell junction assembly#GO:0034329;cellular component organization#GO:0016043;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;regulation of transcription elongation by RNA polymerase II#GO:0034243;regulation of DNA-templated transcription elongation#GO:0032784;regulation of RNA biosynthetic process#GO:2001141;nucleobase-containing compound metabolic process#GO:0006139;positive regulation of RNA biosynthetic process#GO:1902680;biosynthetic process#GO:0009058;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;macromolecule biosynthetic process#GO:0009059;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;transcription by RNA polymerase II#GO:0006366;cell-cell junction organization#GO:0045216;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;cell junction organization#GO:0034330;regulation of cellular process#GO:0050794;nucleic acid metabolic process#GO:0090304;snRNA transcription by RNA polymerase II#GO:0042795;primary metabolic process#GO:0044238;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;snRNA metabolic process#GO:0016073;regulation of DNA-templated transcription#GO:0006355 vesicle#GO:0031982;apical plasma membrane#GO:0016324;intracellular vesicle#GO:0097708;organelle lumen#GO:0043233;transcription elongation factor complex#GO:0008023;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;anchoring junction#GO:0070161;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;cell periphery#GO:0071944;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;membrane#GO:0016020;cell-cell junction#GO:0005911;plasma membrane#GO:0005886;cytoplasm#GO:0005737;bicellular tight junction#GO:0005923;plasma membrane region#GO:0098590;protein-containing complex#GO:0032991;apical part of cell#GO:0045177;apical junction complex#GO:0043296;nuclear protein-containing complex#GO:0140513;cell junction#GO:0030054;tight junction#GO:0070160 general transcription factor#PC00259 HUMAN|HGNC=17710|UniProtKB=Q9Y3P8 Q9Y3P8 SIT1 PTHR15604:SF0 SIGNALING THRESHOLD-REGULATING TRANSMEMBRANE ADAPTER 1 SIGNALING THRESHOLD-REGULATING TRANSMEMBRANE ADAPTER 1 protein binding#GO:0005515;protein-membrane adaptor activity#GO:0043495;binding#GO:0005488;kinase binding#GO:0019900;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;enzyme binding#GO:0019899 biological regulation#GO:0065007;regulation of multicellular organismal process#GO:0051239;regulation of lymphocyte activation#GO:0051249;regulation of cellular process#GO:0050794;regulation of T cell activation#GO:0050863;regulation of immune system process#GO:0002682;regulation of biological process#GO:0050789;regulation of cell activation#GO:0050865;regulation of leukocyte activation#GO:0002694 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HUMAN|HGNC=23438|UniProtKB=Q8IVF1 Q8IVF1 NUTM2A PTHR22879:SF14 NUT FAMILY MEMBER 1 NUT FAMILY MEMBER 2A-RELATED HUMAN|HGNC=4513|UniProtKB=Q9P1P4 Q9P1P4 TAAR3P PTHR24249:SF82 HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR TRACE AMINE-ASSOCIATED RECEPTOR 3-RELATED transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021 HUMAN|HGNC=18420|UniProtKB=Q9BYW2 Q9BYW2 SETD2 PTHR46711:SF1 HISTONE-LYSINE N-METHYLTRANSFERASE SETD2 HISTONE-LYSINE N-METHYLTRANSFERASE SETD2 lysine N-methyltransferase activity#GO:0016278;histone H3 methyltransferase activity#GO:0140938;histone modifying activity#GO:0140993;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;protein-lysine N-methyltransferase activity#GO:0016279;histone methyltransferase activity#GO:0042054;N-methyltransferase activity#GO:0008170;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741;histone H3K36 methyltransferase activity#GO:0046975;protein methyltransferase activity#GO:0008276 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;nucleus#GO:0005634;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 histone modifying enzyme#PC00261 HUMAN|HGNC=4930|UniProtKB=P10074 P10074 ZBTB48 PTHR24390:SF139 ZINC FINGER PROTEIN ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 48 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218 HUMAN|HGNC=2850|UniProtKB=Q9Y6T7 Q9Y6T7 DGKB PTHR11255:SF32 DIACYLGLYCEROL KINASE DIACYLGLYCEROL KINASE BETA phosphotransferase activity, alcohol group as acceptor#GO:0016773;lipid kinase activity#GO:0001727;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740 lipid biosynthetic process#GO:0008610;glycerophospholipid metabolic process#GO:0006650;biosynthetic process#GO:0009058;biological regulation#GO:0065007;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;signal transduction#GO:0007165;neutral lipid metabolic process#GO:0006638;acylglycerol metabolic process#GO:0006639;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474;regulation of cellular process#GO:0050794;phospholipid biosynthetic process#GO:0008654;glycerolipid metabolic process#GO:0046486;response to stimulus#GO:0050896;signaling#GO:0023052;phospholipid metabolic process#GO:0006644;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;organophosphate biosynthetic process#GO:0090407;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 metabolite interconversion enzyme#PC00262;kinase#PC00137 HUMAN|HGNC=3522|UniProtKB=O95677 O95677 EYA4 PTHR10190:SF17 EYES ABSENT PROTEIN PHOSPHATASE EYA4 catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;protein tyrosine phosphatase activity#GO:0004725;hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721 anatomical structure development#GO:0048856;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of DNA metabolic process#GO:0051054;cellular developmental process#GO:0048869;regulation of response to stimulus#GO:0048583;regulation of DNA repair#GO:0006282;developmental process#GO:0032502;regulation of response to stress#GO:0080134;sensory organ development#GO:0007423;positive regulation of DNA repair#GO:0045739;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;positive regulation of response to stimulus#GO:0048584;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;inner ear development#GO:0048839;regulation of primary metabolic process#GO:0080090;ear development#GO:0043583;regulation of cellular response to stress#GO:0080135;positive regulation of metabolic process#GO:0009893;animal gross anatomical part developmental process#GO:0160108;cell differentiation#GO:0030154;regulation of DNA metabolic process#GO:0051052;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;animal organ development#GO:0048513;embryonic morphogenesis#GO:0048598;multicellular organism development#GO:0007275;embryo development#GO:0009790;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;positive regulation of biological process#GO:0048518 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 histone modifying enzyme#PC00261 HUMAN|HGNC=20667|UniProtKB=Q86VQ6 Q86VQ6 TXNRD3 PTHR48105:SF30 THIOREDOXIN REDUCTASE 1-RELATED-RELATED THIOREDOXIN REDUCTASE 3 catalytic activity#GO:0003824;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;antioxidant activity#GO:0016209;oxidoreductase activity#GO:0016491;catalytic activity, acting on a protein#GO:0140096;protein-disulfide reductase activity#GO:0015035;disulfide oxidoreductase activity#GO:0015036 cellular homeostasis#GO:0019725;cell redox homeostasis#GO:0045454;homeostatic process#GO:0042592 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;cytosol#GO:0005829;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 oxidoreductase#PC00176;reductase#PC00198 HUMAN|HGNC=17074|UniProtKB=Q6SZW1 Q6SZW1 SARM1 PTHR22998:SF1 SARM1 NAD(+) HYDROLASE SARM1 hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787;catalytic activity#GO:0003824 pyridine nucleotide catabolic process#GO:0019364;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;nucleoside phosphate catabolic process#GO:1901292;purine nucleotide metabolic process#GO:0006163;pyridine-containing compound catabolic process#GO:0072526;purine-containing compound metabolic process#GO:0072521;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;nucleotide metabolic process#GO:0009117;organophosphate catabolic process#GO:0046434;purine nucleotide catabolic process#GO:0006195;pyridine-containing compound metabolic process#GO:0072524;nucleobase-containing compound metabolic process#GO:0006139;nicotinamide nucleotide metabolic process#GO:0046496;cellular process#GO:0009987;nucleobase-containing compound catabolic process#GO:0034655;organophosphate metabolic process#GO:0019637;NAD+ metabolic process#GO:0019674;nucleobase-containing small molecule metabolic process#GO:0055086;purine-containing compound catabolic process#GO:0072523;metabolic process#GO:0008152;nucleotide catabolic process#GO:0009166 somatodendritic compartment#GO:0036477;cytoplasm#GO:0005737;neuron projection#GO:0043005;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;dendrite#GO:0030425;dendritic tree#GO:0097447;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;neuronal cell body#GO:0043025;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739;cell body#GO:0044297 scaffold/adaptor protein#PC00226 HUMAN|HGNC=31729|UniProtKB=Q0P6D2 Q0P6D2 DIPK1C PTHR21093:SF2 DIVERGENT PROTEIN KINASE DOMAIN 1C-RELATED DIVERGENT PROTEIN KINASE DOMAIN 1C HUMAN|HGNC=9928|UniProtKB=P62877 P62877 RBX1 PTHR11210:SF2 RING BOX E3 UBIQUITIN-PROTEIN LIGASE RBX1 catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;binding#GO:0005488;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;protein binding#GO:0005515 ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;cellular process#GO:0009987;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein modification by small protein conjugation or removal#GO:0070647;catabolic process#GO:0009056;modification-dependent protein catabolic process#GO:0019941;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;protein modification process#GO:0036211 nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cullin-RING ubiquitin ligase complex#GO:0031461;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle#GO:0043229;ubiquitin ligase complex#GO:0000151;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=3559|UniProtKB=P15090 P15090 FABP4 PTHR11955:SF83 FATTY ACID BINDING PROTEIN FATTY ACID-BINDING PROTEIN, ADIPOCYTE ion binding#GO:0043167;carboxylic acid binding#GO:0031406;small molecule binding#GO:0036094;anion binding#GO:0043168;binding#GO:0005488;organic acid binding#GO:0043177;fatty acid binding#GO:0005504;lipid binding#GO:0008289 carboxylic acid transport#GO:0046942;organic acid transport#GO:0015849;transport#GO:0006810;lipid localization#GO:0010876;monocarboxylic acid transport#GO:0015718;establishment of localization#GO:0051234;fatty acid transport#GO:0015908;localization#GO:0051179;macromolecule localization#GO:0033036;lipid transport#GO:0006869 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;cytosol#GO:0005829;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 transfer/carrier protein#PC00219 HUMAN|HGNC=24956|UniProtKB=Q9NRN5 Q9NRN5 OLFML3 PTHR23192:SF8 OLFACTOMEDIN-RELATED OLFACTOMEDIN-LIKE PROTEIN 3 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 structural protein#PC00211 HUMAN|HGNC=14289|UniProtKB=Q9NZ94 Q9NZ94 NLGN3 PTHR43903:SF4 NEUROLIGIN NEUROLIGIN-3 binding#GO:0005488;signaling receptor binding#GO:0005102;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;protein binding#GO:0005515 localization#GO:0051179;cell communication#GO:0007154;anatomical structure development#GO:0048856;system development#GO:0048731;trans-synaptic signaling#GO:0099537;synapse organization#GO:0050808;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;cell junction organization#GO:0034330;modulation of chemical synaptic transmission#GO:0050804;postsynapse organization#GO:0099173;regulation of cell communication#GO:0010646;synaptic vesicle endocytosis#GO:0048488;chemical synaptic transmission#GO:0007268;establishment of localization#GO:0051234;developmental process#GO:0032502;synaptic vesicle cycle#GO:0099504;transport#GO:0006810;synaptic vesicle recycling#GO:0036465;multicellular organismal process#GO:0032501;membrane organization#GO:0061024;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;cellular localization#GO:0051641;animal gross anatomical part developmental process#GO:0160108;cell adhesion#GO:0007155;regulation of signaling#GO:0023051;synapse assembly#GO:0007416;endocytosis#GO:0006897;signaling#GO:0023052;cell junction assembly#GO:0034329;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;membrane assembly#GO:0071709;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;vesicle-mediated transport in synapse#GO:0099003;import into cell#GO:0098657;cellular component assembly#GO:0022607;vesicle-mediated transport#GO:0016192;regulation of trans-synaptic signaling#GO:0099177;nervous system development#GO:0007399;cellular component biogenesis#GO:0044085;synaptic signaling#GO:0099536;cell-cell adhesion#GO:0098609;establishment of localization in cell#GO:0051649;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;cell junction#GO:0030054;plasma membrane#GO:0005886 cell adhesion molecule#PC00069 HUMAN|HGNC=9230|UniProtKB=O43688 O43688 PLPP2 PTHR10165:SF25 LIPID PHOSPHATE PHOSPHATASE PHOSPHOLIPID PHOSPHATASE 2 catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578 lipid modification#GO:0030258;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;biological regulation#GO:0065007;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;signal transduction#GO:0007165;cell communication#GO:0007154;dephosphorylation#GO:0016311;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;phospholipid metabolic process#GO:0006644;signaling#GO:0023052;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;cellular response to stimulus#GO:0051716;phosphate-containing compound metabolic process#GO:0006796;phospholipid dephosphorylation#GO:0046839;regulation of biological process#GO:0050789 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 phosphatase#PC00181;hydrolase#PC00121 HUMAN|HGNC=30795|UniProtKB=A1L157 A1L157 TSPAN11 PTHR19282:SF198 TETRASPANIN TETRASPANIN-11 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HUMAN|HGNC=27297|UniProtKB=Q5VXM1 Q5VXM1 CDCP2 PTHR24251:SF47 OVOCHYMASE-RELATED CUB DOMAIN-CONTAINING PROTEIN 2 protease#PC00190;serine protease#PC00203 HUMAN|HGNC=26223|UniProtKB=Q96QE5 Q96QE5 TEFM PTHR21053:SF2 TRANSCRIPTION ELONGATION FACTOR, MITOCHONDRIAL TRANSCRIPTION ELONGATION FACTOR, MITOCHONDRIAL transcription regulator activity#GO:0140110;transcription elongation factor activity#GO:0003711 membraneless organelle#GO:0043228;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;mitochondrion#GO:0005739;mitochondrial nucleoid#GO:0042645;nucleoid#GO:0009295;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=25210|UniProtKB=Q8WWB5 Q8WWB5 PIH1D2 PTHR22997:SF6 PIH1 DOMAIN-CONTAINING PROTEIN 1 PIH1 DOMAIN-CONTAINING PROTEIN 2 cellular component assembly#GO:0022607;gene expression#GO:0010467;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-RNA complex organization#GO:0071826;protein-containing complex organization#GO:0043933;metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;nucleic acid metabolic process#GO:0090304;protein-containing complex assembly#GO:0065003;RNA metabolic process#GO:0016070;protein-RNA complex assembly#GO:0022618;rRNA processing#GO:0006364;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187 ribonucleoprotein complex#GO:1990904;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=30146|UniProtKB=A6NJG6 A6NJG6 ARGFX PTHR45793:SF16 HOMEOBOX PROTEIN ARGININE-FIFTY HOMEOBOX sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=28843|UniProtKB=Q9HC44 Q9HC44 GPBP1L1 PTHR14339:SF10 VASCULIN VASCULIN-LIKE PROTEIN 1 DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=25502|UniProtKB=Q9NUP7 Q9NUP7 TRMT13 PTHR12998:SF0 TRNA:M(4)X MODIFICATION ENZYME TRM13 HOMOLOG TRNA:M(4)X MODIFICATION ENZYME TRM13 HOMOLOG macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;methylation#GO:0032259;RNA methylation#GO:0001510;macromolecule methylation#GO:0043414;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;RNA biosynthetic process#GO:0032774;tRNA modification#GO:0006400;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;tRNA methylation#GO:0030488;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 HUMAN|HGNC=25228|UniProtKB=Q96HU1 Q96HU1 SGSM3 PTHR22957:SF681 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN SMALL G PROTEIN SIGNALING MODULATOR 3 enzyme activator activity#GO:0008047;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 GTPase-activating protein#PC00257;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HUMAN|HGNC=4243|UniProtKB=P56159 P56159 GFRA1 PTHR10269:SF3 GDNF RECEPTOR ALPHA GDNF FAMILY RECEPTOR ALPHA-1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 multicellular organismal process#GO:0032501;anatomical structure development#GO:0048856;multicellular organism development#GO:0007275;nervous system development#GO:0007399;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502 cell surface#GO:0009986;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;side of membrane#GO:0098552;external side of plasma membrane#GO:0009897;signaling receptor complex#GO:0043235 transmembrane signal receptor#PC00197 HUMAN|HGNC=24030|UniProtKB=A9UHW6 A9UHW6 MIF4GD PTHR23254:SF17 EIF4G DOMAIN PROTEIN MIF4G DOMAIN-CONTAINING PROTEIN translation regulator activity#GO:0045182 regulation of macromolecule biosynthetic process#GO:0010556;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;post-transcriptional regulation of gene expression#GO:0010608;regulation of translational initiation#GO:0006446;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 RNA metabolism protein#PC00031 HUMAN|HGNC=32262|UniProtKB=P0C7W9 P0C7W9 FAM90A14 PTHR16035:SF14 PROTEIN FAM90A1 PROTEIN FAM90A10-RELATED HUMAN|HGNC=53427|UniProtKB=A0A1B0GUJ8 A0A1B0GUJ8 PNMA8C PTHR23095:SF43 PARANEOPLASTIC ANTIGEN PARANEOPLASTIC ANTIGEN-LIKE PROTEIN 8C transcription cofactor#PC00217 HUMAN|HGNC=13505|UniProtKB=Q9HCX3 Q9HCX3 ZNF304 PTHR24377:SF681 IP01015P-RELATED ZINC FINGER PROTEIN 304 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=28755|UniProtKB=Q8IVY1 Q8IVY1 C1orf210 PTHR31450:SF3 LEUCINE-RICH REPEAT-CONTAINING PROTEIN 19 LRRC19 FAMILY MEMBER TYPE III ENDOSOME MEMBRANE PROTEIN TEMP HUMAN|HGNC=9892|UniProtKB=O75884 O75884 RBBP9 PTHR15394:SF3 SERINE HYDROLASE RBBP9 SERINE HYDROLASE RBBP9 HUMAN|HGNC=5345|UniProtKB=P13598 P13598 ICAM2 PTHR13771:SF3 INTERCELLULAR ADHESION MOLECULE INTERCELLULAR ADHESION MOLECULE 2 signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 cell-cell adhesion#GO:0098609;cellular process#GO:0009987;cell adhesion mediated by integrin#GO:0033627;leukocyte cell-cell adhesion#GO:0007159;cell adhesion#GO:0007155 extracellular region#GO:0005576;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 cell adhesion molecule#PC00069 HUMAN|HGNC=23364|UniProtKB=Q969X2 Q969X2 ST6GALNAC6 PTHR45906:SF6 ALPHA-N-ACETYL-NEURAMINYL-2,3-BETA-GALACTOSYL-1, 3-N-ACETYL-GALACTOSAMINIDE ALPHA-2,6-SIALYLTRANSFERASE-LIKE ALPHA-N-ACETYLGALACTOSAMINIDE ALPHA-2,6-SIALYLTRANSFERASE 6 sialyltransferase activity#GO:0008373;glycosyltransferase activity#GO:0016757;transferase activity#GO:0016740;catalytic activity#GO:0003824 carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;sphingolipid biosynthetic process#GO:0030148;ceramide biosynthetic process#GO:0046513;lipid metabolic process#GO:0006629;carbohydrate derivative biosynthetic process#GO:1901137;oligosaccharide metabolic process#GO:0009311;primary metabolic process#GO:0044238;liposaccharide metabolic process#GO:1903509;glycolipid metabolic process#GO:0006664;carbohydrate metabolic process#GO:0005975;glycosphingolipid biosynthetic process#GO:0006688;glycolipid biosynthetic process#GO:0009247;ceramide metabolic process#GO:0006672 HUMAN|HGNC=13933|UniProtKB=Q5SQ64 Q5SQ64 LY6G6F PTHR32286:SF10 LYMPHOCYTE ANTIGEN 6 COMPLEX LOCUS PROTEIN G6F LYMPHOCYTE ANTIGEN 6 COMPLEX LOCUS PROTEIN G6F HUMAN|HGNC=8269|UniProtKB=Q8NG83 Q8NG83 OR2M3 PTHR26453:SF204 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2M3 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 system process#GO:0003008;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;sensory perception#GO:0007600;nervous system process#GO:0050877;response to chemical#GO:0042221;response to stimulus#GO:0050896;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;detection of chemical stimulus#GO:0009593 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=32346|UniProtKB=Q5SR53 Q5SR53 PIK3CD-AS1 PTHR12138:SF165 PRIMATE-EXPANDED PROTEIN FAMILY SUBFAMILY NOT NAMED HUMAN|HGNC=25611|UniProtKB=Q567U6 Q567U6 CCDC93 PTHR16441:SF10 FIDIPIDINE COILED-COIL DOMAIN-CONTAINING PROTEIN 93 endocytic recycling#GO:0032456;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;endosomal transport#GO:0016197;vesicle-mediated transport to the plasma membrane#GO:0098876;intracellular transport#GO:0046907;localization within membrane#GO:0051668;transport#GO:0006810 protein-containing complex#GO:0032991 HUMAN|HGNC=2207|UniProtKB=P29400 P29400 COL4A5 PTHR24023:SF1029 COLLAGEN ALPHA COLLAGEN ALPHA-5(IV) CHAIN structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 external encapsulating structure organization#GO:0045229;cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;cellular process#GO:0009987;cellular component organization#GO:0016043;extracellular structure organization#GO:0043062 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;basement membrane#GO:0005604;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 extracellular matrix structural protein#PC00103;extracellular matrix protein#PC00102 Integrin signalling pathway#P00034>Collagen#P00922 HUMAN|HGNC=83|UniProtKB=P42765 P42765 ACAA2 PTHR18919:SF145 ACETYL-COA C-ACYLTRANSFERASE 3-KETOACYL-COA THIOLASE, MITOCHONDRIAL acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acetyltransferase activity#GO:0016407;catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746 oxoacid metabolic process#GO:0043436;fatty acid catabolic process#GO:0009062;lipid oxidation#GO:0034440;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;small molecule catabolic process#GO:0044282;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;fatty acid beta-oxidation#GO:0006635;lipid metabolic process#GO:0006629;fatty acid oxidation#GO:0019395;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;lipid modification#GO:0030258;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;lipid catabolic process#GO:0016042;monocarboxylic acid catabolic process#GO:0072329 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739 transferase#PC00220;acyltransferase#PC00042 HUMAN|HGNC=10916|UniProtKB=Q9BZW2 Q9BZW2 SLC13A1 PTHR10283:SF65 SOLUTE CARRIER FAMILY 13 MEMBER SOLUTE CARRIER FAMILY 13 MEMBER 1 solute:sodium symporter activity#GO:0015370;monoatomic cation transmembrane transporter activity#GO:0008324;symporter activity#GO:0015293;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;secondary active transmembrane transporter activity#GO:0015291 metal ion transport#GO:0030001;cellular process#GO:0009987;sodium ion transport#GO:0006814;inorganic anion transport#GO:0015698;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227;secondary carrier transporter#PC00258 HUMAN|HGNC=7798|UniProtKB=Q15653 Q15653 NFKBIB PTHR47303:SF1 FAMILY NOT NAMED NF-KAPPA-B INHIBITOR BETA cellular response to stimulus#GO:0051716;response to molecule of bacterial origin#GO:0002237;cellular response to biotic stimulus#GO:0071216;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;response to oxygen-containing compound#GO:1901700;cellular response to chemical stimulus#GO:0070887;response to bacterium#GO:0009617;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;cellular response to lipopolysaccharide#GO:0071222;response to biotic stimulus#GO:0009607;response to other organism#GO:0051707;cellular response to lipid#GO:0071396;response to lipid#GO:0033993;response to chemical#GO:0042221;response to external stimulus#GO:0009605;response to lipopolysaccharide#GO:0032496;cellular response to molecule of bacterial origin#GO:0071219 HUMAN|HGNC=28393|UniProtKB=Q8IUW3 Q8IUW3 SPATA2L PTHR15326:SF7 SPERMATOGENESIS-ASSOCIATED PROTEIN 2/TAMOZHENNIC SPERMATOGENESIS-ASSOCIATED PROTEIN 2-LIKE PROTEIN cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=23024|UniProtKB=Q8N668 Q8N668 COMMD1 PTHR21199:SF1 COMM DOMAIN-CONTAINING PROTEIN 1 COMM DOMAIN-CONTAINING PROTEIN 1 structural molecule activity#GO:0005198;protein complex scaffold activity#GO:0140378 positive regulation of protein ubiquitination#GO:0031398;vesicle-mediated transport#GO:0016192;positive regulation of macromolecule metabolic process#GO:0010604;regulation of proteasomal protein catabolic process#GO:0061136;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;establishment of localization#GO:0051234;regulation of catabolic process#GO:0009894;regulation of protein modification process#GO:0031399;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;transport#GO:0006810;regulation of protein ubiquitination#GO:0031396;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of protein modification by small protein conjugation or removal#GO:1903320;regulation of biological process#GO:0050789;regulation of post-translational protein modification#GO:1901873;positive regulation of metabolic process#GO:0009893;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434;localization#GO:0051179;regulation of protein catabolic process#GO:0042176;positive regulation of protein metabolic process#GO:0051247 endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;intracellular organelle#GO:0043229 HUMAN|HGNC=6144|UniProtKB=P53708 P53708 ITGA8 PTHR23220:SF5 INTEGRIN ALPHA INTEGRIN ALPHA-8 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell-cell adhesion#GO:0098609;integrin-mediated signaling pathway#GO:0007229;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cell surface receptor signaling pathway#GO:0007166;cell-matrix adhesion#GO:0007160;cell adhesion#GO:0007155;cell-substrate adhesion#GO:0031589;cell communication#GO:0007154 integrin complex#GO:0008305;signaling receptor complex#GO:0043235;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cell surface#GO:0009986;plasma membrane#GO:0005886;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;protein complex involved in cell adhesion#GO:0098636 cell adhesion molecule#PC00069;integrin#PC00126 Integrin signalling pathway#P00034>Collagen#P00922;Integrin signalling pathway#P00034>Integrin alpha#P00941 HUMAN|HGNC=44439|UniProtKB=C9JVI0 C9JVI0 USP17L11 PTHR24006:SF651 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE INACTIVE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 17-LIKE PROTEIN 4-RELATED hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;cysteine-type deubiquitinase activity#GO:0004843;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234 regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of biological quality#GO:0065008;regulation of programmed cell death#GO:0043067;regulation of biological process#GO:0050789;regulation of protein stability#GO:0031647;regulation of apoptotic process#GO:0042981 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cytosol#GO:0005829;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 protease#PC00190;cysteine protease#PC00081 HUMAN|HGNC=800|UniProtKB=P50993 P50993 ATP1A2 PTHR43294:SF6 SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA-2 primary active transmembrane transporter activity#GO:0015399;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;monoatomic ion transmembrane transporter activity#GO:0015075;P-type ion transporter activity#GO:0015662;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic cation transmembrane transporter activity#GO:0008324;potassium ion transmembrane transporter activity#GO:0015079;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829 potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801;intracellular chemical homeostasis#GO:0055082;inorganic cation import across plasma membrane#GO:0098659;cellular homeostasis#GO:0019725;potassium ion import across plasma membrane#GO:1990573;establishment of localization#GO:0051234;import into cell#GO:0098657;chemical homeostasis#GO:0048878;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;metal ion transport#GO:0030001;export from cell#GO:0140352;homeostatic process#GO:0042592;inorganic ion import across plasma membrane#GO:0099587;import across plasma membrane#GO:0098739;sodium ion transport#GO:0006814;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;potassium ion homeostasis#GO:0055075;transmembrane transport#GO:0055085;inorganic ion homeostasis#GO:0098771 transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;ATPase dependent transmembrane transport complex#GO:0098533;membrane protein complex#GO:0098796;membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;cation-transporting ATPase complex#GO:0090533;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane#GO:0005886 transporter#PC00227;primary active transporter#PC00068 HUMAN|HGNC=14502|UniProtKB=P82664 P82664 MRPS10 PTHR13334:SF4 MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S10 SMALL RIBOSOMAL SUBUNIT PROTEIN US10M mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 translational protein#PC00263;ribosomal protein#PC00202 HUMAN|HGNC=13090|UniProtKB=P17039 P17039 ZNF30 PTHR24377:SF826 IP01015P-RELATED ZINC FINGER PROTEIN 30 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=25939|UniProtKB=Q96GS4 Q96GS4 BORCS6 PTHR13440:SF8 BLOC-1 RELATED COMPLEX SUBUNIT 6 BLOC-1-RELATED COMPLEX SUBUNIT 6 localization#GO:0051179;organelle localization#GO:0051640;lysosome localization#GO:0032418 intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991 HUMAN|HGNC=19192|UniProtKB=Q8N1I0 Q8N1I0 DOCK4 PTHR45653:SF7 DEDICATOR OF CYTOKINESIS DEDICATOR OF CYTOKINESIS PROTEIN 4 GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;small GTPase binding#GO:0031267;protein binding#GO:0005515;binding#GO:0005488;guanyl-nucleotide exchange factor activity#GO:0005085;enzyme binding#GO:0019899 cellular response to chemical stimulus#GO:0070887;chemotaxis#GO:0006935;response to external stimulus#GO:0009605;cell chemotaxis#GO:0060326;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell motility#GO:0048870;cell migration#GO:0016477;response to stimulus#GO:0050896;response to chemical#GO:0042221;taxis#GO:0042330;locomotion#GO:0040011 cell periphery#GO:0071944;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein modulator#PC00022;protein-binding activity modulator#PC00095;guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=29301|UniProtKB=Q9P206 Q9P206 NHSL3 PTHR23039:SF6 NANCE-HORAN SYNDROME PROTEIN NHS-LIKE PROTEIN 3 HUMAN|HGNC=14045|UniProtKB=Q9BYN8 Q9BYN8 MRPS26 PTHR21035:SF2 28S RIBOSOMAL PROTEIN S26, MITOCHONDRIAL SMALL RIBOSOMAL SUBUNIT PROTEIN MS26 intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;small ribosomal subunit#GO:0015935;mitochondrial ribosome#GO:0005761;intracellular anatomical structure#GO:0005622;organellar ribosome#GO:0000313;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;ribosome#GO:0005840;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;membraneless organelle#GO:0043228;mitochondrial small ribosomal subunit#GO:0005763;membrane-enclosed lumen#GO:0031974;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232 ribosomal protein#PC00202;translational protein#PC00263 HUMAN|HGNC=3483|UniProtKB=Q16134 Q16134 ETFDH PTHR10617:SF107 ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE, MITOCHONDRIAL electron transfer activity#GO:0009055;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 cellular process#GO:0009987;generation of precursor metabolites and energy#GO:0006091;electron transport chain#GO:0022900;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;mitochondrial inner membrane#GO:0005743;organelle envelope#GO:0031967;membrane#GO:0016020 oxidoreductase#PC00176 HUMAN|HGNC=3571|UniProtKB=O60488 O60488 ACSL4 PTHR43272:SF22 LONG-CHAIN-FATTY-ACID--COA LIGASE LONG-CHAIN-FATTY-ACID--COA LIGASE 4 ligase activity, forming carbon-sulfur bonds#GO:0016877;catalytic activity#GO:0003824;ATP-dependent activity#GO:0140657;ligase activity#GO:0016874 neurogenesis#GO:0022008;acyl-CoA metabolic process#GO:0006637;nucleobase-containing small molecule metabolic process#GO:0055086;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;lipid metabolic process#GO:0006629;developmental process#GO:0032502;neuron differentiation#GO:0030182;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;nervous system development#GO:0007399;nucleobase-containing compound metabolic process#GO:0006139;multicellular organismal process#GO:0032501;cellular process#GO:0009987;sulfur compound metabolic process#GO:0006790;long-chain fatty acid metabolic process#GO:0001676;organophosphate metabolic process#GO:0019637;system development#GO:0048731;anatomical structure development#GO:0048856;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;oxoacid metabolic process#GO:0043436;nucleoside phosphate metabolic process#GO:0006753;cell differentiation#GO:0030154;small molecule metabolic process#GO:0044281;purine-containing compound metabolic process#GO:0072521;carboxylic acid metabolic process#GO:0019752;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;monocarboxylic acid metabolic process#GO:0032787 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;membrane#GO:0016020;cell periphery#GO:0071944;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;lipid droplet#GO:0005811;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 ligase#PC00142 HUMAN|HGNC=9296|UniProtKB=Q12972 Q12972 PPP1R8 PTHR23308:SF74 NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1 NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE 1 phosphatase regulator activity#GO:0019208;phosphatase inhibitor activity#GO:0019212;molecular function regulator activity#GO:0098772;protein phosphatase inhibitor activity#GO:0004864;enzyme inhibitor activity#GO:0004857;enzyme regulator activity#GO:0030234;protein phosphatase regulator activity#GO:0019888;molecular function inhibitor activity#GO:0140678;protein serine/threonine phosphatase inhibitor activity#GO:0004865 cellular developmental process#GO:0048869;neurogenesis#GO:0022008;neuron projection guidance#GO:0097485;regulation of response to stimulus#GO:0048583;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;multicellular organismal process#GO:0032501;positive regulation of response to stimulus#GO:0048584;plasma membrane bounded cell projection organization#GO:0120036;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cellular response to growth factor stimulus#GO:0090287;axon guidance#GO:0007411;axon development#GO:0061564;regulation of BMP signaling pathway#GO:0030510;positive regulation of cellular process#GO:0048522;anatomical structure development#GO:0048856;system development#GO:0048731;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092;positive regulation of signal transduction#GO:0009967;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cell projection morphogenesis#GO:0048858;positive regulation of BMP signaling pathway#GO:0030513;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;neuron projection development#GO:0031175;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of signaling#GO:0023056;axonogenesis#GO:0007409;neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;regulation of signaling#GO:0023051;generation of neurons#GO:0048699;cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell development#GO:0048468;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789 intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nuclear speck#GO:0016607;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membraneless organelle#GO:0043232;nuclear body#GO:0016604;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;membraneless organelle#GO:0043228 RNA splicing factor#PC00148 Adrenaline and noradrenaline biosynthesis#P00001>SNARE#P00072;Parkinson disease#P00049>Syntaxin#P01215 HUMAN|HGNC=3396|UniProtKB=O15197 O15197 EPHB6 PTHR46877:SF15 EPH RECEPTOR A5 EPHRIN TYPE-B RECEPTOR 6 transmembrane signaling receptor activity#GO:0004888;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein tyrosine kinase activity#GO:0004714;molecular transducer activity#GO:0060089;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;signaling receptor activity#GO:0038023;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity, acting on a protein#GO:0140096 plasma membrane bounded cell projection morphogenesis#GO:0120039;cell surface receptor signaling pathway#GO:0007166;neuron differentiation#GO:0030182;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cell projection morphogenesis#GO:0048858;neuron projection development#GO:0031175;cellular process#GO:0009987;signal transduction#GO:0007165;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;axonogenesis#GO:0007409;neuron development#GO:0048666;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cell morphogenesis#GO:0000902;cell differentiation#GO:0030154;response to stimulus#GO:0050896;cell projection organization#GO:0030030;cell development#GO:0048468;signaling#GO:0023052;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;neuron projection guidance#GO:0097485;axon guidance#GO:0007411;axon development#GO:0061564;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;system development#GO:0048731;cellular response to stimulus#GO:0051716;ephrin receptor signaling pathway#GO:0048013;regulation of cellular process#GO:0050794 neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020;cell projection#GO:0042995;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165;dendritic tree#GO:0097447;dendrite#GO:0030425 transmembrane signal receptor#PC00197 HUMAN|HGNC=17721|UniProtKB=Q5TEA3 Q5TEA3 DNAAF9 PTHR33664:SF1 RCG26366 DYNEIN AXONEMAL ASSEMBLY FACTOR 9 HUMAN|HGNC=10752|UniProtKB=P63302 P63302 SELENOW PTHR15124:SF16 SELENOPROTEIN W SELENOPROTEIN W cell development#GO:0048468;homeostatic process#GO:0042592;hemopoiesis#GO:0030097;multicellular organismal process#GO:0032501;myeloid cell differentiation#GO:0030099;cell differentiation#GO:0030154;cellular process#GO:0009987;multicellular organismal-level homeostasis#GO:0048871;erythrocyte differentiation#GO:0030218;anatomical structure development#GO:0048856;cellular developmental process#GO:0048869;homeostasis of number of cells#GO:0048872;developmental process#GO:0032502;immune system process#GO:0002376 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 HUMAN|HGNC=30803|UniProtKB=Q49AG3 Q49AG3 ZBED5 PTHR45935:SF34 PROTEIN ZBED8-RELATED ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 5 HUMAN|HGNC=28783|UniProtKB=Q7Z7K0 Q7Z7K0 CMC1 PTHR22977:SF5 COX ASSEMBLY MITOCHONDRIAL PROTEIN COX ASSEMBLY MITOCHONDRIAL PROTEIN HOMOLOG membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739 HUMAN|HGNC=11440|UniProtKB=Q13190 Q13190 STX5 PTHR19957:SF3 SYNTAXIN SYNTAXIN-5 SNAP receptor activity#GO:0005484;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 membrane organization#GO:0061024;organelle membrane fusion#GO:0090174;organelle fusion#GO:0048284;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;organelle organization#GO:0006996;macromolecule localization#GO:0033036;membrane fusion#GO:0061025;intracellular protein localization#GO:0008104;vesicle organization#GO:0016050;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;Golgi vesicle transport#GO:0048193;transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;vesicle fusion#GO:0006906;cellular component organization#GO:0016043;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;protein transport#GO:0015031;localization#GO:0051179;cellular localization#GO:0051641 protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasm#GO:0005737;membrane#GO:0016020;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;organelle#GO:0043226;SNARE complex#GO:0031201;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 SNARE protein#PC00034 Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>SNARE Complex#P01079;Nicotinic acetylcholine receptor signaling pathway#P00044>SNARE Complex#P01091 HUMAN|HGNC=10023|UniProtKB=Q92963 Q92963 RIT1 PTHR24070:SF208 RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY GTP-BINDING PROTEIN RIT1 hydrolase activity#GO:0016787;protein binding#GO:0005515;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity, acting on acid anhydrides#GO:0016817;calmodulin binding#GO:0005516;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;biological regulation#GO:0065007;signaling#GO:0023052;small GTPase-mediated signal transduction#GO:0007264;intracellular signaling cassette#GO:0141124;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;Ras protein signal transduction#GO:0007265;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 small GTPase#PC00208 HUMAN|HGNC=25168|UniProtKB=Q96DY2 Q96DY2 DRC10 PTHR31598:SF1 IQ DOMAIN-CONTAINING PROTEIN D DYNEIN REGULATORY COMPLEX SUBUNIT 10 HUMAN|HGNC=16248|UniProtKB=Q9H106 Q9H106 SIRPD PTHR19971:SF25 SIGNAL-REGULATORY PROTEIN BETA SIGNAL-REGULATORY PROTEIN DELTA cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=2336|UniProtKB=P20023 P20023 CR2 PTHR19325:SF391 COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING COMPLEMENT RECEPTOR TYPE 2 immune system process#GO:0002376;regulation of lymphocyte mediated immunity#GO:0002706;T cell mediated immunity#GO:0002456;regulation of immune response#GO:0050776;negative regulation of immune response#GO:0050777;regulation of immune effector process#GO:0002697;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;negative regulation of biological process#GO:0048519;regulation of leukocyte mediated immunity#GO:0002703;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of immune system process#GO:0002682;regulation of response to stimulus#GO:0048583;immune effector process#GO:0002252;immune response#GO:0006955;negative regulation of response to stimulus#GO:0048585;negative regulation of immune system process#GO:0002683;biological regulation#GO:0065007;adaptive immune response#GO:0002250 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;extracellular region#GO:0005576;cell periphery#GO:0071944 defense/immunity protein#PC00090;complement component#PC00078 HUMAN|HGNC=17230|UniProtKB=Q9BYQ9 Q9BYQ9 KRTAP4-8 PTHR23262:SF67 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 4-8 multicellular organismal process#GO:0032501 structural protein#PC00211 HUMAN|HGNC=34490|UniProtKB=Q6UX52 Q6UX52 C17orf99 PTHR11481:SF67 IMMUNOGLOBULIN FC RECEPTOR PROTEIN IL-40 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;immune system process#GO:0002376;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;immune response#GO:0006955;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020;plasma membrane#GO:0005886;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;cell surface#GO:0009986 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=3014|UniProtKB=Q16555 Q16555 DPYSL2 PTHR11647:SF56 HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER DIHYDROPYRIMIDINASE-RELATED PROTEIN 2 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity#GO:0016787;dihydropyrimidinase activity#GO:0004157;catalytic activity#GO:0003824;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides#GO:0016812 pyrimidine nucleobase catabolic process#GO:0006208;primary metabolic process#GO:0044238;pyrimidine-containing compound metabolic process#GO:0072527;cellular process#GO:0009987;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;nucleobase catabolic process#GO:0046113;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;pyrimidine nucleobase metabolic process#GO:0006206;nucleobase-containing small molecule metabolic process#GO:0055086;nucleobase metabolic process#GO:0009112 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 hydrolase#PC00121 Axon guidance mediated by semaphorins#P00007>CRMP#P00339;Pyrimidine Metabolism#P02771>Dihydropyrimidinase#P03125 HUMAN|HGNC=28117|UniProtKB=Q9BTD8 Q9BTD8 RBM42 PTHR47640:SF11 TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED RNA-BINDING PROTEIN 42 nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;RNA binding#GO:0003723 HUMAN|HGNC=12684|UniProtKB=O15240 O15240 VGF PTHR15159:SF2 NEUROSECRETORY PROTEIN VGF NEUROSECRETORY PROTEIN VGF neuropeptide hormone activity#GO:0005184;hormone activity#GO:0005179;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545 regulation of cellular process#GO:0050794;regulation of trans-synaptic signaling#GO:0099177;signaling#GO:0023052;cell-cell signaling#GO:0007267;modulation of chemical synaptic transmission#GO:0050804;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;synaptic signaling#GO:0099536;regulation of biological process#GO:0050789;cellular process#GO:0009987;regulation of neuronal synaptic plasticity#GO:0048168;cell communication#GO:0007154;regulation of biological quality#GO:0065008;regulation of synaptic plasticity#GO:0048167;regulation of signaling#GO:0023051 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HUMAN|HGNC=4428|UniProtKB=Q8TBA6 Q8TBA6 GOLGA5 PTHR13815:SF7 GOLGIN-84 GOLGIN SUBFAMILY A MEMBER 5 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 vesicle-mediated transport#GO:0016192;endomembrane system organization#GO:0010256;cellular component organization#GO:0016043;retrograde transport, vesicle recycling within Golgi#GO:0000301;organelle organization#GO:0006996;intra-Golgi vesicle-mediated transport#GO:0006891;cellular process#GO:0009987;Golgi organization#GO:0007030;establishment of localization#GO:0051234;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;Golgi vesicle transport#GO:0048193;transport#GO:0006810 intracellular organelle#GO:0043229;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi stack#GO:0005795;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;Golgi cisterna#GO:0031985;endomembrane system#GO:0012505;cytoplasm#GO:0005737 HUMAN|HGNC=68|UniProtKB=O14678 O14678 ABCD4 PTHR11384:SF59 ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER LYSOSOMAL COBALAMIN TRANSPORTER ABCD4 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657;primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804 primary active transporter#PC00068;ATP-binding cassette (ABC) transporter#PC00003 HUMAN|HGNC=9554|UniProtKB=Q99460 Q99460 PSMD1 PTHR10943:SF2 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987 intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;endopeptidase complex#GO:1905369;intracellular membraneless organelle#GO:0043232;peptidase complex#GO:1905368;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;proteasome complex#GO:0000502;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 protease#PC00190 Ubiquitin proteasome pathway#P00060>26S proteasome#P01489 HUMAN|HGNC=11270|UniProtKB=O43597 O43597 SPRY2 PTHR12365:SF8 SPROUTY PROTEIN SPROUTY HOMOLOG 2 kinase inhibitor activity#GO:0019210;protein kinase regulator activity#GO:0019887;protein kinase inhibitor activity#GO:0004860;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;enzyme inhibitor activity#GO:0004857;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678 regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648;regulation of Ras protein signal transduction#GO:0046578;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of MAPK cascade#GO:0043409;regulation of biological process#GO:0050789;regulation of ERBB signaling pathway#GO:1901184;negative regulation of biological process#GO:0048519;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of response to stimulus#GO:0048583;regulation of MAPK cascade#GO:0043408;negative regulation of cellular process#GO:0048523;regulation of small GTPase mediated signal transduction#GO:0051056;regulation of epidermal growth factor receptor signaling pathway#GO:0042058;negative regulation of signal transduction#GO:0009968;regulation of cellular response to growth factor stimulus#GO:0090287;regulation of signal transduction#GO:0009966;regulation of fibroblast growth factor receptor signaling pathway#GO:0040036;biological regulation#GO:0065007;negative regulation of response to stimulus#GO:0048585;regulation of ERK1 and ERK2 cascade#GO:0070372;negative regulation of ERK1 and ERK2 cascade#GO:0070373 intracellular membraneless organelle#GO:0043232;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 scaffold/adaptor protein#PC00226 EGF receptor signaling pathway#P00018>SPRY#G01511;EGF receptor signaling pathway#P00018>Spry#P00541;FGF signaling pathway#P00021>Spry#P00626 HUMAN|HGNC=970|UniProtKB=Q8N3I7 Q8N3I7 BBS5 PTHR21351:SF0 BARDET-BIEDL SYNDROME PROTEIN 5 BBSOME COMPLEX MEMBER BBS5 binding#GO:0005488;phospholipid binding#GO:0005543;lipid binding#GO:0008289;phosphatidylinositol-3-phosphate binding#GO:0032266;phosphatidylinositol phosphate binding#GO:1901981 cellular component assembly#GO:0022607;cell projection organization#GO:0030030;plasma membrane bounded cell projection organization#GO:0120036;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782;organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cilium#GO:0005929;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membraneless organelle#GO:0043228;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;ciliary basal body#GO:0036064;intracellular membraneless organelle#GO:0043232;BBSome#GO:0034464;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630 HUMAN|HGNC=33593|UniProtKB=Q6L9T8 Q6L9T8 FAM72D PTHR31841:SF1 PROTEIN FAM72A-RELATED PROTEIN FAM72A-RELATED cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=17650|UniProtKB=Q7Z6J0 Q7Z6J0 SH3RF1 PTHR14167:SF44 SH3 DOMAIN-CONTAINING E3 UBIQUITIN-PROTEIN LIGASE SH3RF1 molecular adaptor activity#GO:0060090;transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;protein-macromolecule adaptor activity#GO:0030674;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659 positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;generation of neurons#GO:0048699;regulation of intracellular signal transduction#GO:1902531;positive regulation of JNK cascade#GO:0046330;animal gross anatomical part developmental process#GO:0160108;cell differentiation#GO:0030154;regulation of biological process#GO:0050789;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;regulation of JNK cascade#GO:0046328;multicellular organism development#GO:0007275;regulation of apoptotic process#GO:0042981;regulation of MAPK cascade#GO:0043408;nervous system development#GO:0007399;cellular process#GO:0009987;negative regulation of programmed cell death#GO:0043069;positive regulation of biological process#GO:0048518;system development#GO:0048731;anatomical structure development#GO:0048856;regulation of cell communication#GO:0010646;positive regulation of cell communication#GO:0010647;cell motility#GO:0048870;regulation of cellular process#GO:0050794;positive regulation of signal transduction#GO:0009967;neurogenesis#GO:0022008;positive regulation of MAPK cascade#GO:0043410;cellular developmental process#GO:0048869;neuron migration#GO:0001764;regulation of response to stimulus#GO:0048583;developmental process#GO:0032502;positive regulation of intracellular signal transduction#GO:1902533;negative regulation of cellular process#GO:0048523;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;cell migration#GO:0016477;negative regulation of apoptotic process#GO:0043066;positive regulation of response to stimulus#GO:0048584;positive regulation of cellular process#GO:0048522 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=5192|UniProtKB=Q14469 Q14469 HES1 PTHR10985:SF153 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED TRANSCRIPTION FACTOR HES-1 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 anterior/posterior pattern specification#GO:0009952;negative regulation of RNA biosynthetic process#GO:1902679;cell surface receptor signaling pathway#GO:0007166;negative regulation of RNA metabolic process#GO:0051253;multicellular organism development#GO:0007275;negative regulation of macromolecule biosynthetic process#GO:0010558;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of multicellular organismal process#GO:0051239;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of multicellular organismal development#GO:2000026;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;signaling#GO:0023052;negative regulation of metabolic process#GO:0009892;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;regulation of cell differentiation#GO:0045595;Notch signaling pathway#GO:0007219;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;regulation of cell development#GO:0060284;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;regulation of neuron differentiation#GO:0045664;regionalization#GO:0003002;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;pattern specification process#GO:0007389;cell communication#GO:0007154;regulation of nervous system development#GO:0051960;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;regulation of neurogenesis#GO:0050767;cellular response to stimulus#GO:0051716;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of developmental process#GO:0050793 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 basic helix-loop-helix transcription factor#PC00055 Notch signaling pathway#P00045>E(spl)-C genes#G01541 HUMAN|HGNC=30690|UniProtKB=P0CG40 P0CG40 SP9 PTHR23235:SF26 KRUEPPEL-LIKE TRANSCRIPTION FACTOR TRANSCRIPTION FACTOR SP9 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=26658|UniProtKB=Q8NA72 Q8NA72 POC5 PTHR28618:SF1 CENTROSOMAL PROTEIN POC5 CENTROSOMAL PROTEIN POC5 HUMAN|HGNC=18452|UniProtKB=Q8ND25 Q8ND25 ZNRF1 PTHR46661:SF2 E3 UBIQUITIN-PROTEIN LIGASE ZNRF1-LIKE PROTEIN E3 UBIQUITIN-PROTEIN LIGASE ZNRF1 catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630 protein modification by small protein conjugation or removal#GO:0070647;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein modification process#GO:0036211;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;catabolic process#GO:0009056;protein K48-linked ubiquitination#GO:0070936;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;cellular process#GO:0009987;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;proteasomal protein catabolic process#GO:0010498 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=16309|UniProtKB=A6NI73 A6NI73 LILRA5 PTHR11738:SF194 MHC CLASS I NK CELL RECEPTOR LEUKOCYTE IMMUNOGLOBULIN-LIKE RECEPTOR SUBFAMILY A MEMBER 5 signaling receptor activity#GO:0038023;immune receptor activity#GO:0140375;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 cytokine-mediated signaling pathway#GO:0019221;regulation of immune response#GO:0050776;cell communication#GO:0007154;response to peptide#GO:1901652;cellular response to stimulus#GO:0051716;immune response-regulating signaling pathway#GO:0002764;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166;cellular process#GO:0009987;signal transduction#GO:0007165;response to chemical#GO:0042221;response to cytokine#GO:0034097;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=943|UniProtKB=O14514 O14514 ADGRB1 PTHR12011:SF39 ADHESION G-PROTEIN COUPLED RECEPTOR ADHESION G PROTEIN-COUPLED RECEPTOR B1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 G protein-coupled receptor signaling pathway#GO:0007186;localization#GO:0051179;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;signaling#GO:0023052;endocytosis#GO:0006897;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;transport#GO:0006810;membrane invagination#GO:0010324;phagocytosis#GO:0006909;import into cell#GO:0098657;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;apoptotic cell clearance#GO:0043277;phagocytosis, engulfment#GO:0006911;cellular process#GO:0009987;signal transduction#GO:0007165;membrane organization#GO:0061024;biological regulation#GO:0065007 cell junction#GO:0030054;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;postsynaptic specialization#GO:0099572;neuron to neuron synapse#GO:0098984;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;dendrite#GO:0030425;dendritic tree#GO:0097447;postsynaptic density#GO:0014069;postsynapse#GO:0098794;organelle#GO:0043226;asymmetric synapse#GO:0032279;cellular anatomical structure#GO:0110165;synapse#GO:0045202;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 p53 pathway#P00059>BAI-1#G04699 HUMAN|HGNC=14027|UniProtKB=Q9NYK5 Q9NYK5 MRPL39 PTHR42753:SF9 MITOCHONDRIAL RIBOSOME PROTEIN L39/PROLYL-TRNA LIGASE FAMILY MEMBER LARGE RIBOSOMAL SUBUNIT PROTEIN ML39 catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;ligase activity#GO:0016874 RNA metabolic process#GO:0016070;protein metabolic process#GO:0019538;translation#GO:0006412;protein biosynthetic process#GO:0160307;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;amino acid activation#GO:0043038;macromolecule metabolic process#GO:0043170;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;gene expression#GO:0010467;amino acid metabolic process#GO:0006520;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;tRNA aminoacylation#GO:0043039;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;tRNA aminoacylation for protein translation#GO:0006418 mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 translational protein#PC00263;aminoacyl-tRNA synthetase#PC00047 HUMAN|HGNC=9248|UniProtKB=O75335 O75335 PPFIA4 PTHR12587:SF5 LAR INTERACTING PROTEIN LIP -RELATED PROTEIN LIPRIN-ALPHA-4 structural molecule activity#GO:0005198;protein complex scaffold activity#GO:0140378 cell junction organization#GO:0034330;cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;cellular process#GO:0009987;synapse organization#GO:0050808 synapse#GO:0045202;cellular anatomical structure#GO:0110165;presynaptic active zone#GO:0048786;cell junction#GO:0030054;presynapse#GO:0098793 scaffold/adaptor protein#PC00226 HUMAN|HGNC=20611|UniProtKB=Q71RS6 Q71RS6 SLC24A5 PTHR10846:SF61 SODIUM/POTASSIUM/CALCIUM EXCHANGER SODIUM_POTASSIUM_CALCIUM EXCHANGER 5 transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;antiporter activity#GO:0015297;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;calcium channel activity#GO:0005262;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;sodium ion transmembrane transporter activity#GO:0015081;active transmembrane transporter activity#GO:0022804;monoatomic cation channel activity#GO:0005261;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079 intracellular calcium ion homeostasis#GO:0006874;intracellular chemical homeostasis#GO:0055082;calcium ion transport#GO:0006816;cellular homeostasis#GO:0019725;establishment of localization#GO:0051234;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;transport#GO:0006810;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;homeostatic process#GO:0042592;metal ion transport#GO:0030001;intracellular monoatomic ion homeostasis#GO:0006873;calcium ion transmembrane transport#GO:0070588 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;cell periphery#GO:0071944;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;plasma membrane#GO:0005886;intracellular membrane-bounded organelle#GO:0043231;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737 secondary carrier transporter#PC00258 HUMAN|HGNC=14440|UniProtKB=Q6P1L5 Q6P1L5 FAM117B PTHR14972:SF6 AGAP011572-PA PROTEIN FAM117B HUMAN|HGNC=4876|UniProtKB=Q15034 Q15034 HERC3 PTHR45622:SF18 UBIQUITIN-PROTEIN LIGASE E3A-RELATED E3 UBIQUITIN-PROTEIN LIGASE HERC3-RELATED aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746 protein modification process#GO:0036211;primary metabolic process#GO:0044238;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;protein modification by small protein conjugation or removal#GO:0070647;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;cellular process#GO:0009987;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=725|UniProtKB=Q13508 Q13508 ART3 PTHR10339:SF4 ADP-RIBOSYLTRANSFERASE ECTO-ADP-RIBOSYLTRANSFERASE 3 glycosyltransferase activity#GO:0016757;pentosyltransferase activity#GO:0016763;NAD+ poly-ADP-ribosyltransferase activity#GO:0003950;transferase activity#GO:0016740;catalytic activity#GO:0003824 transferase#PC00220 HUMAN|HGNC=8765|UniProtKB=O75340 O75340 PDCD6 PTHR46212:SF3 PEFLIN PROGRAMMED CELL DEATH PROTEIN 6 HUMAN|HGNC=26938|UniProtKB=Q53FT3 Q53FT3 HIKESHI PTHR12925:SF2 HIKESHI FAMILY MEMBER PROTEIN HIKESHI heat shock protein binding#GO:0031072;nucleocytoplasmic carrier activity#GO:0140142;protein-folding chaperone binding#GO:0051087;molecular carrier activity#GO:0140104;binding#GO:0005488;Hsp70 protein binding#GO:0030544;protein binding#GO:0005515 establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule localization#GO:0033036;import into nucleus#GO:0051170;protein localization to nucleus#GO:0034504;transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;protein localization to organelle#GO:0033365;nucleocytoplasmic transport#GO:0006913;nuclear transport#GO:0051169;protein import into nucleus#GO:0006606;protein transport#GO:0015031;localization#GO:0051179;cellular localization#GO:0051641 cytosol#GO:0005829;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=24182|UniProtKB=O75973 O75973 C1QL1 PTHR22923:SF64 CEREBELLIN-RELATED C1Q-RELATED FACTOR cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 scaffold/adaptor protein#PC00226 HUMAN|HGNC=24118|UniProtKB=Q8IXQ6 Q8IXQ6 PARP9 PTHR14453:SF70 PARP/ZINC FINGER CCCH TYPE DOMAIN CONTAINING PROTEIN PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP9 glycosyltransferase activity#GO:0016757;ubiquitin-like protein ligase binding#GO:0044389;transferase activity#GO:0016740;transcription corepressor activity#GO:0003714;catalytic activity#GO:0003824;transcription coregulator activity#GO:0003712;protein binding#GO:0005515;transcription regulator activity#GO:0140110;enzyme binding#GO:0019899;pentosyltransferase activity#GO:0016763;binding#GO:0005488;NAD+ poly-ADP-ribosyltransferase activity#GO:0003950 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of innate immune response#GO:0045089;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of signal transduction#GO:0009966;regulation of response to stress#GO:0080134;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;positive regulation of defense response#GO:0031349;positive regulation of immune response#GO:0050778;regulation of biosynthetic process#GO:0009889;regulation of innate immune response#GO:0045088;regulation of gene expression#GO:0010468;positive regulation of response to biotic stimulus#GO:0002833;positive regulation of signal transduction#GO:0009967;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of macromolecule metabolic process#GO:0060255;regulation of response to biotic stimulus#GO:0002831;regulation of cell communication#GO:0010646;regulation of defense response#GO:0031347;regulation of immune response#GO:0050776;positive regulation of immune system process#GO:0002684;regulation of response to cytokine stimulus#GO:0060759;negative regulation of macromolecule biosynthetic process#GO:0010558;positive regulation of biological process#GO:0048518;regulation of response to external stimulus#GO:0032101;positive regulation of response to external stimulus#GO:0032103;regulation of cytokine-mediated signaling pathway#GO:0001959;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of metabolic process#GO:0009892;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;positive regulation of cytokine-mediated signaling pathway#GO:0001961 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 HUMAN|HGNC=6771|UniProtKB=Q99717 Q99717 SMAD5 PTHR13703:SF36 SMAD SMAD FAMILY MEMBER 5 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;protein binding#GO:0005515;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690 cellular response to growth factor stimulus#GO:0071363;signaling#GO:0023052;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;cell surface receptor signaling pathway#GO:0007166;cellular response to BMP stimulus#GO:0071773;intracellular signaling cassette#GO:0141124;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;cellular process#GO:0009987;signal transduction#GO:0007165;transforming growth factor beta receptor signaling pathway#GO:0007179;intracellular signal transduction#GO:0035556;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;cell communication#GO:0007154;response to transforming growth factor beta#GO:0071559;regulation of cellular process#GO:0050794;response to growth factor#GO:0070848;regulation of macromolecule metabolic process#GO:0060255;BMP signaling pathway#GO:0030509;cellular response to stimulus#GO:0051716;cellular response to transforming growth factor beta stimulus#GO:0071560;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;response to BMP#GO:0071772;developmental process#GO:0032502;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 Gonadotropin-releasing hormone receptor pathway#P06664>SMAD1/5/8#P06787;Gonadotropin-releasing hormone receptor pathway#P06664>SMAD2-4#P06819;TGF-beta signaling pathway#P00052>RSmads#P01292;Wnt signaling pathway#P00057>Smad4#P01455 HUMAN|HGNC=2907|UniProtKB=P80370 P80370 DLK1 PTHR24052:SF11 DELTA-RELATED PROTEIN DELTA HOMOLOG 1 cellular anatomical structure#GO:0110165;membrane#GO:0016020 intercellular signal molecule#PC00207;membrane-bound signaling molecule#PC00152 Notch signaling pathway#P00045>Delta#P01116;Angiogenesis#P00005>Delta/Serrate#P00226 HUMAN|HGNC=15842|UniProtKB=Q96RT1 Q96RT1 ERBIN PTHR45752:SF47 LEUCINE-RICH REPEAT-CONTAINING ERBIN negative regulation of cell communication#GO:0010648;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;negative regulation of intracellular signal transduction#GO:1902532;regulation of immune response#GO:0050776;regulation of defense response#GO:0031347;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;signaling#GO:0023052;regulation of response to biotic stimulus#GO:0002831;regulation of cell communication#GO:0010646;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;negative regulation of biological process#GO:0048519;regulation of innate immune response#GO:0045088;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;regulation of response to stress#GO:0080134;negative regulation of immune system process#GO:0002683;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of signal transduction#GO:0009968;negative regulation of response to stimulus#GO:0048585;regulation of response to external stimulus#GO:0032101;signal transduction#GO:0007165;cellular process#GO:0009987 scaffold/adaptor protein#PC00226 HUMAN|HGNC=14285|UniProtKB=Q96DS6 Q96DS6 MS4A6E PTHR23320:SF153 MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 6E cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;trans-Golgi network#GO:0005802;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cell periphery#GO:0071944;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020 transporter#PC00227 HUMAN|HGNC=8490|UniProtKB=O43929 O43929 ORC4 PTHR12087:SF0 ORIGIN RECOGNITION COMPLEX SUBUNIT 4 ORIGIN RECOGNITION COMPLEX SUBUNIT 4 double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;DNA replication origin binding#GO:0003688;nucleic acid binding#GO:0003676;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;molecular adaptor activity#GO:0060090 macromolecule metabolic process#GO:0043170;DNA-templated DNA replication#GO:0006261;DNA replication initiation#GO:0006270;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;DNA replication#GO:0006260;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;chromosome#GO:0005694;nuclear protein-containing complex#GO:0140513;origin recognition complex#GO:0000808;membraneless organelle#GO:0043228;nuclear origin of replication recognition complex#GO:0005664;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 DNA metabolism protein#PC00009;replication origin binding protein#PC00199 HUMAN|HGNC=29183|UniProtKB=Q9UPU7 Q9UPU7 TBC1D2B PTHR22957:SF621 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN TBC1 DOMAIN FAMILY MEMBER 2B enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HUMAN|HGNC=21073|UniProtKB=Q8NBS9 Q8NBS9 TXNDC5 PTHR45672:SF3 PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED THIOREDOXIN DOMAIN-CONTAINING PROTEIN 5 isomerase activity#GO:0016853;intramolecular oxidoreductase activity#GO:0016860;catalytic activity, acting on a protein#GO:0140096;protein disulfide isomerase activity#GO:0003756;catalytic activity#GO:0003824 metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;protein folding#GO:0006457 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 chaperone#PC00072 HUMAN|HGNC=6259|UniProtKB=O60928 O60928 KCNJ13 PTHR11767:SF3 INWARD RECTIFIER POTASSIUM CHANNEL INWARD RECTIFIER POTASSIUM CHANNEL 13 transporter activity#GO:0005215;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261;potassium channel activity#GO:0005267;ligand-gated monoatomic ion channel activity#GO:0015276;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079 monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;inorganic ion import across plasma membrane#GO:0099587;metal ion transport#GO:0030001;import across plasma membrane#GO:0098739;inorganic cation import across plasma membrane#GO:0098659;import into cell#GO:0098657;establishment of localization#GO:0051234;potassium ion import across plasma membrane#GO:1990573;transport#GO:0006810;monoatomic ion transmembrane transport#GO:0034220;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 ion channel#PC00133 HUMAN|HGNC=16709|UniProtKB=Q16602 Q16602 CALCRL PTHR45620:SF21 PDF RECEPTOR-LIKE PROTEIN-RELATED CALCITONIN GENE-RELATED PEPTIDE TYPE 1 RECEPTOR G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930 cellular process#GO:0009987;signal transduction#GO:0007165;multicellular organismal process#GO:0032501;tube development#GO:0035295;biological regulation#GO:0065007;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;developmental process#GO:0032502;multicellular organism development#GO:0007275;vasculature development#GO:0001944;anatomical structure formation involved in morphogenesis#GO:0048646;blood vessel morphogenesis#GO:0048514;cellular response to stimulus#GO:0051716;tube morphogenesis#GO:0035239;blood vessel development#GO:0001568;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;regulation of cellular process#GO:0050794;circulatory system development#GO:0072359;response to stimulus#GO:0050896;signaling#GO:0023052;animal gross anatomical part developmental process#GO:0160108;G protein-coupled receptor signaling pathway#GO:0007186;anatomical structure development#GO:0048856;angiogenesis#GO:0001525;cell communication#GO:0007154;system development#GO:0048731 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=27318|UniProtKB=Q8IVC4 Q8IVC4 ZNF584 PTHR24377:SF611 IP01015P-RELATED ZINC FINGER PROTEIN 584 cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=37285|UniProtKB=Q8N7X2 Q8N7X2 STPG3 PTHR21580:SF25 SHIPPO-1-RELATED PROTEIN STPG3 reproductive process#GO:0022414;cell motility#GO:0048870;microtubule-based movement#GO:0007018;sperm motility#GO:0097722;cellular process#GO:0009987;cilium movement involved in cell motility#GO:0060294;microtubule-based process#GO:0007017;cilium-dependent cell motility#GO:0060285;cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;flagellated sperm motility#GO:0030317 9+2 motile cilium#GO:0097729;intracellular organelle#GO:0043229;cilium#GO:0005929;cytoskeleton#GO:0005856;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;motile cilium#GO:0031514;cellular anatomical structure#GO:0110165;sperm flagellum#GO:0036126 structural protein#PC00211 HUMAN|HGNC=15767|UniProtKB=Q96AC1 Q96AC1 FERMT2 PTHR16160:SF11 FERMITIN 2-RELATED FERMITIN FAMILY HOMOLOG 2 integrin binding#GO:0005178;protein-containing complex binding#GO:0044877;protein binding#GO:0005515;cell adhesion molecule binding#GO:0050839;signaling receptor binding#GO:0005102;binding#GO:0005488 cell-substrate adhesion#GO:0031589;cellular process#GO:0009987;cell-matrix adhesion#GO:0007160;cell adhesion#GO:0007155 cell-substrate junction#GO:0030055;focal adhesion#GO:0005925;anchoring junction#GO:0070161;cell junction#GO:0030054;cellular anatomical structure#GO:0110165 HUMAN|HGNC=31073|UniProtKB=Q9Y2K3 Q9Y2K3 MYH15 PTHR45615:SF26 MYOSIN HEAVY CHAIN, NON-MUSCLE MYOSIN-15 isomerase activity#GO:0016853;cytoskeletal motor activity#GO:0003774;macromolecular conformation isomerase activity#GO:0120543;cytoskeletal protein binding#GO:0008092;catalytic activity#GO:0003824;microfilament motor activity#GO:0000146;protein-containing complex binding#GO:0044877;protein binding#GO:0005515;actin binding#GO:0003779;actin filament binding#GO:0051015;ATP-dependent activity#GO:0140657;binding#GO:0005488;polypeptide conformation or assembly isomerase activity#GO:0120544 cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;supramolecular complex#GO:0099080;organelle#GO:0043226;myosin complex#GO:0016459;actin cytoskeleton#GO:0015629;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 actin or actin-binding cytoskeletal protein#PC00041 Cytoskeletal regulation by Rho GTPase#P00016>Myosin#P00522;Wnt signaling pathway#P00057>NFAT Target Genes#G01559;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Myosin#P00867;Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HUMAN|HGNC=16315|UniProtKB=Q96L94 Q96L94 SNX22 PTHR15813:SF8 SORTING NEXIN-22 AND 24 SORTING NEXIN-22 lipid binding#GO:0008289;phosphatidylinositol phosphate binding#GO:1901981;phospholipid binding#GO:0005543;binding#GO:0005488 scaffold/adaptor protein#PC00226 HUMAN|HGNC=6226|UniProtKB=Q96RP8 Q96RP8 KCNA7 PTHR11537:SF155 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 7 voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261 cellular process#GO:0009987;potassium ion transport#GO:0006813;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;action potential#GO:0001508;metal ion transport#GO:0030001;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008 transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane#GO:0005886;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944 ion channel#PC00133;voltage-gated ion channel#PC00241 HUMAN|HGNC=347|UniProtKB=Q09666 Q09666 AHNAK PTHR23348:SF41 PERIAXIN/AHNAK NEUROBLAST DIFFERENTIATION-ASSOCIATED PROTEIN AHNAK regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 HUMAN|HGNC=26535|UniProtKB=Q5VXU9 Q5VXU9 SHOC1 PTHR35668:SF1 PROTEIN SHORTAGE IN CHIASMATA 1 ORTHOLOG PROTEIN SHORTAGE IN CHIASMATA 1 ORTHOLOG DNA binding#GO:0003677;single-stranded DNA binding#GO:0003697;nucleic acid binding#GO:0003676;binding#GO:0005488 organelle fission#GO:0048285;meiosis I cell cycle process#GO:0061982;nuclear division#GO:0000280;sexual reproduction#GO:0019953;reciprocal meiotic recombination#GO:0007131;reproductive process#GO:0022414;homologous recombination#GO:0035825;cell cycle#GO:0007049;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;meiotic cell cycle process#GO:1903046;cellular component organization#GO:0016043;meiosis I#GO:0007127;reciprocal homologous recombination#GO:0140527;cell cycle process#GO:0022402;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;meiotic nuclear division#GO:0140013;meiotic cell cycle#GO:0051321;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;DNA recombination#GO:0006310;nucleobase-containing compound metabolic process#GO:0006139;organelle organization#GO:0006996;resolution of meiotic recombination intermediates#GO:0000712;cellular process#GO:0009987 intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;condensed nuclear chromosome#GO:0000794;membraneless organelle#GO:0043228;condensed chromosome#GO:0000793;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 HUMAN|HGNC=18621|UniProtKB=Q9Y2V7 Q9Y2V7 COG6 PTHR21506:SF0 COMPONENT OF OLIGOMERIC GOLGI COMPLEX 6 CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 6 localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;Golgi vesicle transport#GO:0048193;transport#GO:0006810;endomembrane system organization#GO:0010256;vesicle-mediated transport#GO:0016192;Golgi organization#GO:0007030;cellular process#GO:0009987;intra-Golgi vesicle-mediated transport#GO:0006891;retrograde transport, vesicle recycling within Golgi#GO:0000301;organelle organization#GO:0006996;cellular component organization#GO:0016043 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;vesicle tethering complex#GO:0099023;COG complex#GO:0017119 HUMAN|HGNC=8806|UniProtKB=P08559 P08559 PDHA1 PTHR11516:SF52 PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA, SOMATIC FORM, MITOCHONDRIAL oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the aldehyde or oxo group of donors#GO:0016903;catalytic activity#GO:0003824 nucleobase-containing small molecule metabolic process#GO:0055086;acyl-CoA metabolic process#GO:0006637;energy derivation by oxidation of organic compounds#GO:0015980;nucleoside phosphate biosynthetic process#GO:1901293;generation of precursor metabolites and energy#GO:0006091;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;cellular process#GO:0009987;sulfur compound metabolic process#GO:0006790;organophosphate metabolic process#GO:0019637;aerobic respiration#GO:0009060;organophosphate biosynthetic process#GO:0090407;cellular respiration#GO:0045333;oxoacid metabolic process#GO:0043436;acetyl-CoA metabolic process#GO:0006084;purine-containing compound biosynthetic process#GO:0072522;nucleoside phosphate metabolic process#GO:0006753;pyruvate metabolic process#GO:0006090;small molecule metabolic process#GO:0044281;purine-containing compound metabolic process#GO:0072521;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;monocarboxylic acid metabolic process#GO:0032787 organelle lumen#GO:0043233;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;acetyltransferase complex#GO:1902493;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;oxidoreductase complex#GO:1990204;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;transferase complex#GO:1990234 dehydrogenase#PC00092;oxidoreductase#PC00176 Pyruvate metabolism#P02772>Pyruvate Dehydrogenase#P03133;TCA cycle#P00051>Pyruvate Dehydrogenase#P01266 HUMAN|HGNC=5001|UniProtKB=Q9NP66 Q9NP66 HMG20A PTHR46040:SF1 HIGH MOBILITY GROUP PROTEIN 2 HIGH MOBILITY GROUP PROTEIN 20A regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=7856|UniProtKB=P16083 P16083 NQO2 PTHR10204:SF33 NAD P H OXIDOREDUCTASE-RELATED RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE [QUINONE] oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor#GO:0016655;oxidoreductase activity, acting on NAD(P)H#GO:0016651;NAD(P)H dehydrogenase (quinone) activity#GO:0003955;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 oxidoreductase#PC00176 HUMAN|HGNC=18184|UniProtKB=Q96GG9 Q96GG9 DCUN1D1 PTHR12281:SF10 RP42 RELATED DCN1-LIKE PROTEIN 1 catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;binding#GO:0005488;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;protein binding#GO:0005515 biological regulation#GO:0065007;positive regulation of macromolecule metabolic process#GO:0010604;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of protein modification by small protein conjugation or removal#GO:1903320;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;regulation of protein modification process#GO:0031399;regulation of post-translational protein modification#GO:1901873;positive regulation of metabolic process#GO:0009893;positive regulation of protein metabolic process#GO:0051247 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=26282|UniProtKB=Q8N4S0 Q8N4S0 CCDC82 PTHR14689:SF0 PHORBOL-ESTER_DAG-TYPE DOMAIN-CONTAINING PROTEIN COILED-COIL DOMAIN-CONTAINING PROTEIN 82 HUMAN|HGNC=28687|UniProtKB=Q6UX73 Q6UX73 C16orf89 PTHR33539:SF1 UPF0764 PROTEIN C16ORF89 UPF0764 PROTEIN C16ORF89 cytosol#GO:0005829;membrane#GO:0016020;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=15868|UniProtKB=Q8N2K0 Q8N2K0 ABHD12 PTHR12277:SF61 ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN LYSOPHOSPHATIDYLSERINE LIPASE ABHD12 glycerophospholipase activity#GO:0004620;lipase activity#GO:0016298;catalytic activity#GO:0003824;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788;phospholipase activity#GO:0120569;hydrolase activity#GO:0016787 modified amino acid metabolic process#GO:0006575;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;phospholipid metabolic process#GO:0006644;phospholipid catabolic process#GO:0009395;glycerolipid metabolic process#GO:0046486;catabolic process#GO:0009056;glycerolipid catabolic process#GO:0046503;organophosphate catabolic process#GO:0046434;cellular process#GO:0009987;lipid catabolic process#GO:0016042;organophosphate metabolic process#GO:0019637;glycerophospholipid metabolic process#GO:0006650;lipid metabolic process#GO:0006629;neutral lipid catabolic process#GO:0046461;acylglycerol metabolic process#GO:0006639;metabolic process#GO:0008152;acylglycerol catabolic process#GO:0046464;neutral lipid metabolic process#GO:0006638;glycerophospholipid catabolic process#GO:0046475 endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane#GO:0016020;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 serine protease#PC00203 HUMAN|HGNC=24699|UniProtKB=Q8TEJ3 Q8TEJ3 SH3RF3 PTHR14167:SF62 SH3 DOMAIN-CONTAINING E3 UBIQUITIN-PROTEIN LIGASE SH3RF3 ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;protein-macromolecule adaptor activity#GO:0030674;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;molecular adaptor activity#GO:0060090;transferase activity#GO:0016740;catalytic activity#GO:0003824 negative regulation of cellular process#GO:0048523;positive regulation of intracellular signal transduction#GO:1902533;regulation of MAPK cascade#GO:0043408;regulation of response to stimulus#GO:0048583;regulation of apoptotic process#GO:0042981;regulation of JNK cascade#GO:0046328;positive regulation of MAPK cascade#GO:0043410;negative regulation of programmed cell death#GO:0043069;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of response to stimulus#GO:0048584;negative regulation of apoptotic process#GO:0043066;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of intracellular signal transduction#GO:1902531;positive regulation of JNK cascade#GO:0046330;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;positive regulation of signal transduction#GO:0009967;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;regulation of biological process#GO:0050789;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646 scaffold/adaptor protein#PC00226 HUMAN|HGNC=5553|UniProtKB=A0A0A0MS14 A0A0A0MS14 IGHV1-45 PTHR23266:SF285 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 1-45 antigen binding#GO:0003823;binding#GO:0005488 immunoglobulin mediated immune response#GO:0016064;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;immune effector process#GO:0002252;immune system process#GO:0002376;adaptive immune response#GO:0002250;response to stimulus#GO:0050896;immune response#GO:0006955 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=24790|UniProtKB=Q6ZSC3 Q6ZSC3 RBM43 PTHR15225:SF8 INTERFERON-INDUCED PROTEIN 35/NMI N-MYC/STAT INTERACTING PROTEIN RNA-BINDING PROTEIN 43 transcription cofactor#PC00217 HUMAN|HGNC=782|UniProtKB=O95260 O95260 ATE1 PTHR21367:SF1 ARGININE-TRNA-PROTEIN TRANSFERASE 1 ARGINYL-TRNA--PROTEIN TRANSFERASE 1 aminoacyltransferase activity#GO:0016755;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a protein#GO:0140096;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a tRNA#GO:0140101;acyltransferase activity#GO:0016746 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;cellular process#GO:0009987;primary metabolic process#GO:0044238 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 translational protein#PC00263 HUMAN|HGNC=8605|UniProtKB=Q86W56 Q86W56 PARG PTHR12837:SF15 POLY ADP-RIBOSE GLYCOHYDROLASE POLY(ADP-RIBOSE) GLYCOHYDROLASE hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553 nucleotide metabolic process#GO:0009117;regulation of cellular response to stress#GO:0080135;ribonucleotide metabolic process#GO:0009259;small molecule metabolic process#GO:0044281;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521;regulation of DNA metabolic process#GO:0051052;regulation of biological process#GO:0050789;purine nucleotide metabolic process#GO:0006163;nucleobase-containing small molecule metabolic process#GO:0055086;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;cellular process#GO:0009987;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;nucleoside triphosphate metabolic process#GO:0009141;nucleoside phosphate metabolic process#GO:0006753;primary metabolic process#GO:0044238;purine nucleoside triphosphate metabolic process#GO:0009144;macromolecule metabolic process#GO:0043170;regulation of response to stress#GO:0080134;regulation of response to stimulus#GO:0048583;regulation of DNA repair#GO:0006282;regulation of nucleobase-containing compound metabolic process#GO:0019219;nucleotide-sugar metabolic process#GO:0009225;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;organophosphate metabolic process#GO:0019637;regulation of primary metabolic process#GO:0080090;purine ribonucleoside triphosphate metabolic process#GO:0009205;carbohydrate derivative metabolic process#GO:1901135 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 glycosidase#PC00110 HUMAN|HGNC=19975|UniProtKB=Q8IZV5 Q8IZV5 RDH10 PTHR24322:SF755 PKSB RETINOL DEHYDROGENASE 10 oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824 intracellular organelle#GO:0043229;organelle#GO:0043226;membraneless organelle#GO:0043228;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;lipid droplet#GO:0005811;intracellular anatomical structure#GO:0005622 dehydrogenase#PC00092 HUMAN|HGNC=26588|UniProtKB=Q8N292 Q8N292 GAPT PTHR37350:SF1 PROTEIN GAPT PROTEIN GAPT multicellular organismal process#GO:0032501;lymphocyte activation#GO:0046649;lymphocyte proliferation#GO:0046651;lymphocyte homeostasis#GO:0002260;cellular process#GO:0009987;lymphocyte activation involved in immune response#GO:0002285;immune response#GO:0006955;B cell activation#GO:0042113;multicellular organismal-level homeostasis#GO:0048871;leukocyte proliferation#GO:0070661;immune effector process#GO:0002252;leukocyte activation involved in immune response#GO:0002366;response to stimulus#GO:0050896;mononuclear cell proliferation#GO:0032943;homeostatic process#GO:0042592;leukocyte activation#GO:0045321;cell activation involved in immune response#GO:0002263;B cell proliferation#GO:0042100;B cell activation involved in immune response#GO:0002312;immune system process#GO:0002376;cell activation#GO:0001775;cell population proliferation#GO:0008283;homeostasis of number of cells#GO:0048872 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HUMAN|HGNC=49371|UniProtKB=A8MWD9 A8MWD9 SNRPGP15 PTHR10553:SF26 SMALL NUCLEAR RIBONUCLEOPROTEIN SMALL NUCLEAR RIBONUCLEOPROTEIN G-RELATED RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;mRNA splicing, via spliceosome#GO:0000398;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397 small nuclear ribonucleoprotein complex#GO:0030532;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;U2 snRNP#GO:0005686;P granule#GO:0043186;nuclear protein-containing complex#GO:0140513;U5 snRNP#GO:0005682;spliceosomal complex#GO:0005681;U2-type spliceosomal complex#GO:0005684;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;SMN-Sm protein complex#GO:0034719;nucleus#GO:0005634;ribonucleoprotein granule#GO:0035770;U1 snRNP#GO:0005685;U12-type spliceosomal complex#GO:0005689;catalytic step 2 spliceosome#GO:0071013;membraneless organelle#GO:0043228;Sm-like protein family complex#GO:0120114;U2-type prespliceosome#GO:0071004;intracellular membrane-bounded organelle#GO:0043231;U4 snRNP#GO:0005687;cytoplasmic ribonucleoprotein granule#GO:0036464;catalytic complex#GO:1902494;spliceosomal tri-snRNP complex#GO:0097526;precatalytic spliceosome#GO:0071011;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;spliceosomal snRNP complex#GO:0097525 RNA splicing factor#PC00148 HUMAN|HGNC=13811|UniProtKB=Q6U841 Q6U841 SLC4A10 PTHR11453:SF32 ANION EXCHANGE PROTEIN SODIUM-DRIVEN CHLORIDE BICARBONATE EXCHANGER symporter activity#GO:0015293;monoatomic cation transmembrane transporter activity#GO:0008324;solute:sodium symporter activity#GO:0015370;monoatomic anion transmembrane transporter activity#GO:0008509;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;antiporter activity#GO:0015297;bicarbonate transmembrane transporter activity#GO:0015106;chloride transmembrane transporter activity#GO:0015108;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;solute:monoatomic cation symporter activity#GO:0015294;monoatomic ion transmembrane transporter activity#GO:0015075 homeostatic process#GO:0042592;intracellular monoatomic ion homeostasis#GO:0006873;transmembrane transport#GO:0055085;localization#GO:0051179;regulation of biological quality#GO:0065008;regulation of pH#GO:0006885;regulation of intracellular pH#GO:0051453;biological regulation#GO:0065007;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;establishment of localization#GO:0051234;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;intracellular monoatomic cation homeostasis#GO:0030003;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;transport#GO:0006810 plasma membrane#GO:0005886;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;basal plasma membrane#GO:0009925;cell periphery#GO:0071944;basal part of cell#GO:0045178;basolateral plasma membrane#GO:0016323;membrane#GO:0016020 secondary carrier transporter#PC00258 HUMAN|HGNC=21389|UniProtKB=Q6MZW2 Q6MZW2 FSTL4 PTHR10913:SF9 FOLLISTATIN-RELATED FOLLISTATIN-RELATED PROTEIN 4 developmental process#GO:0032502;cellular process#GO:0009987;cell differentiation#GO:0030154;cellular developmental process#GO:0048869 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease inhibitor#PC00191 HUMAN|Ensembl=ENSG00000287839.3|UniProtKB=A0AAQ5BHU3 A0AAQ5BHU3 PTHR41694:SF3 ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN ENDOGENOUS RETROVIRUS GROUP K MEMBER 10 POL PROTEIN-RELATED RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 viral or transposable element protein#PC00237 HUMAN|HGNC=603|UniProtKB=P04114 P04114 APOB PTHR13769:SF1 APOLIPOPROTEIN B APOLIPOPROTEIN B-100 protein binding#GO:0005515;lipid transfer activity#GO:0120013;lipoprotein particle receptor binding#GO:0070325;lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104;signaling receptor binding#GO:0005102;binding#GO:0005488;cholesterol transfer activity#GO:0120020;sterol transfer activity#GO:0120015;transporter activity#GO:0005215 cholesterol transport#GO:0030301;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of protein localization#GO:0045184;lipid transport#GO:0006869;acylglycerol metabolic process#GO:0006639;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;chemical homeostasis#GO:0048878;transport#GO:0006810;triglyceride metabolic process#GO:0006641;cholesterol homeostasis#GO:0042632;sterol transport#GO:0015918;establishment of localization#GO:0051234;neutral lipid metabolic process#GO:0006638;intracellular protein localization#GO:0008104;lipid homeostasis#GO:0055088;primary metabolic process#GO:0044238;glycerolipid metabolic process#GO:0046486;homeostatic process#GO:0042592;lipid localization#GO:0010876;localization#GO:0051179;protein transport#GO:0015031;organic hydroxy compound transport#GO:0015850 very-low-density lipoprotein particle#GO:0034361;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;lipoprotein particle#GO:1990777;extracellular region#GO:0005576;extracellular protein-containing complex#GO:0140392;protein-lipid complex#GO:0032994;plasma lipoprotein particle#GO:0034358 apolipoprotein#PC00052;transfer/carrier protein#PC00219 HUMAN|HGNC=27441|UniProtKB=Q3KP22 Q3KP22 MAJIN PTHR35824:SF1 MEMBRANE-ANCHORED JUNCTION PROTEIN MAJIN MEMBRANE-ANCHORED JUNCTION PROTEIN cellular process#GO:0009987;organelle organization#GO:0006996;chromosome localization#GO:0050000;homologous chromosome pairing at meiosis#GO:0007129;chromosome segregation#GO:0007059;chromosome organization involved in meiotic cell cycle#GO:0070192;meiotic cell cycle#GO:0051321;meiotic chromosome segregation#GO:0045132;chromosome organization#GO:0051276;cellular component organization or biogenesis#GO:0071840;homologous chromosome segregation#GO:0045143;meiotic nuclear division#GO:0140013;cell cycle process#GO:0022402;telomere localization#GO:0034397;cell cycle#GO:0007049;meiosis I#GO:0007127;cellular component organization#GO:0016043;nuclear chromosome segregation#GO:0098813;meiotic cell cycle process#GO:1903046;reproductive process#GO:0022414;sexual reproduction#GO:0019953;meiosis I cell cycle process#GO:0061982;telomere tethering at nuclear periphery#GO:0034398;organelle localization#GO:0051640;nuclear division#GO:0000280;localization#GO:0051179;organelle fission#GO:0048285 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;membrane#GO:0016020;organelle envelope#GO:0031967;organelle inner membrane#GO:0019866;nucleus#GO:0005634;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;nuclear inner membrane#GO:0005637;membrane-bounded organelle#GO:0043227;nuclear membrane#GO:0031965;intracellular organelle#GO:0043229 HUMAN|HGNC=19275|UniProtKB=Q5GAN6 Q5GAN6 RNASE10 PTHR11437:SF63 RIBONUCLEASE INACTIVE RIBONUCLEASE-LIKE PROTEIN 10 catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;nuclease activity#GO:0004518;RNA nuclease activity#GO:0004540;catalytic activity, acting on RNA#GO:0140098 response to other organism#GO:0051707;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;defense response to Gram-positive bacterium#GO:0050830;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;defense response#GO:0006952;response to external stimulus#GO:0009605;defense response to bacterium#GO:0042742;response to bacterium#GO:0009617 endoribonuclease#PC00094;RNA metabolism protein#PC00031 HUMAN|HGNC=2024|UniProtKB=P51797 P51797 CLCN6 PTHR11689:SF158 CHLORIDE CHANNEL PROTEIN CLC FAMILY MEMBER H(+)_CL(-) EXCHANGE TRANSPORTER 6 gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;channel activity#GO:0015267;monoatomic anion channel activity#GO:0005253;voltage-gated channel activity#GO:0022832;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic anion transmembrane transporter activity#GO:0008509;chloride transmembrane transporter activity#GO:0015108;passive transmembrane transporter activity#GO:0022803;chloride channel activity#GO:0005254;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;voltage-gated monoatomic anion channel activity#GO:0008308 transport#GO:0006810;monoatomic anion transport#GO:0006820;chloride transport#GO:0006821;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698;establishment of localization#GO:0051234;localization#GO:0051179 cytoplasm#GO:0005737;vacuole#GO:0005773;endomembrane system#GO:0012505;late endosome#GO:0005770;lysosomal membrane#GO:0005765;membrane#GO:0016020;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;vacuolar membrane#GO:0005774;lytic vacuole#GO:0000323;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;lysosome#GO:0005764;vesicle#GO:0031982;lytic vacuole membrane#GO:0098852;intracellular vesicle#GO:0097708;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;intracellular organelle#GO:0043229 ion channel#PC00133 HUMAN|HGNC=29612|UniProtKB=Q13571 Q13571 LAPTM5 PTHR12479:SF2 LYSOSOMAL-ASSOCIATED TRANSMEMBRANE PROTEIN LYSOSOMAL-ASSOCIATED TRANSMEMBRANE PROTEIN 5 protein sequestering activity#GO:0140311;molecular sequestering activity#GO:0140313 regulation of membrane permeability#GO:0090559;regulation of biological quality#GO:0065008;biological regulation#GO:0065007 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;lysosome#GO:0005764;lytic vacuole membrane#GO:0098852;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;vacuolar membrane#GO:0005774;lytic vacuole#GO:0000323;lysosomal membrane#GO:0005765;membrane#GO:0016020;cytoplasm#GO:0005737;vacuole#GO:0005773 transporter#PC00227 HUMAN|HGNC=12644|UniProtKB=Q15836 Q15836 VAMP3 PTHR45701:SF6 SYNAPTOBREVIN FAMILY MEMBER VESICLE-ASSOCIATED MEMBRANE PROTEIN 3 SNARE binding#GO:0000149;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;binding#GO:0005488;protein binding#GO:0005515;SNAP receptor activity#GO:0005484;syntaxin binding#GO:0019905 membrane fusion#GO:0061025;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;organelle fusion#GO:0048284;cellular component assembly#GO:0022607;organelle membrane fusion#GO:0090174;membrane organization#GO:0061024;transport#GO:0006810;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;vesicle organization#GO:0016050;protein-containing complex organization#GO:0043933;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;vesicle fusion#GO:0006906;localization#GO:0051179 intracellular anatomical structure#GO:0005622;SNARE complex#GO:0031201;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cytoplasm#GO:0005737;membrane protein complex#GO:0098796;membrane#GO:0016020;cell periphery#GO:0071944 membrane traffic protein#PC00150 Metabotropic glutamate receptor group II pathway#P00040>SNARE Complex#P01049;Opioid proopiomelanocortin pathway#P05917>SNARE Complex#P06005;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>SNARE Complex#P01066;Thyrotropin-releasing hormone receptor signaling pathway#P04394>SNARE Complex#P04582;Oxytocin receptor mediated signaling pathway#P04391>SNARE Complex#P04532;Cortocotropin releasing factor receptor signaling pathway#P04380>SNARE Complex#P04457;Nicotinic acetylcholine receptor signaling pathway#P00044>SNARE Complex#P01091;Ionotropic glutamate receptor pathway#P00037>SNARE Complex#P01013;Metabotropic glutamate receptor group III pathway#P00039>SNARE Complex#P01042;Alpha adrenergic receptor signaling pathway#P00002>SNARE#P00074;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>SNARE Complex#P01079;5HT4 type receptor mediated signaling pathway#P04376>SNARE Complex#P04428;Beta1 adrenergic receptor signaling pathway#P04377>SNARE Complex#P04435;Adrenaline and noradrenaline biosynthesis#P00001>SNARE#P00072;5HT1 type receptor mediated signaling pathway#P04373>SNARE Complex#P04405;5HT2 type receptor mediated signaling pathway#P04374>SNARE Complex#P04415;Opioid proenkephalin pathway#P05915>SNARE Complex#P05986;Opioid prodynorphin pathway#P05916>SNARE Complex#P05996;Dopamine receptor mediated signaling pathway#P05912>SNARE Complex#P05956;Beta2 adrenergic receptor signaling pathway#P04378>SNARE Complex#P04442;Beta3 adrenergic receptor signaling pathway#P04379>SNARE Complex#P04447;5HT3 type receptor mediated signaling pathway#P04375>SNARE Complex#P04423 HUMAN|HGNC=1599|UniProtKB=O60563 O60563 CCNT1 PTHR10026:SF42 CYCLIN CYCLIN-T1 protein kinase activator activity#GO:0030295;protein serine/threonine kinase activator activity#GO:0043539;enzyme activator activity#GO:0008047;cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;protein kinase regulator activity#GO:0019887;cyclin-dependent protein kinase regulator activity#GO:0019914;kinase activator activity#GO:0019209;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234 positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of DNA-templated transcription, elongation#GO:0032786;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription elongation#GO:0032784 organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;transcription elongation factor complex#GO:0008023;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;protein-containing complex#GO:0032991;transferase complex#GO:1990234;protein kinase complex#GO:1902911;nuclear protein-containing complex#GO:0140513 kinase modulator#PC00140;kinase activator#PC00138 HUMAN|HGNC=32034|UniProtKB=Q5TEC3 Q5TEC3 ZNF697 PTHR23226:SF207 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER PROTEIN 697 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=10301|UniProtKB=P62913 P62913 RPL11 PTHR11994:SF47 60S RIBOSOMAL PROTEIN L11-RELATED LARGE RIBOSOMAL SUBUNIT PROTEIN UL5 nucleic acid binding#GO:0003676;binding#GO:0005488;structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198;RNA binding#GO:0003723 biosynthetic process#GO:0009058;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;translation#GO:0006412;metabolic process#GO:0008152 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;ribosome#GO:0005840;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625;cytosol#GO:0005829 translational protein#PC00263;ribosomal protein#PC00202 HUMAN|HGNC=23695|UniProtKB=Q155Q3 Q155Q3 DIXDC1 PTHR10878:SF22 SEGMENT POLARITY PROTEIN DISHEVELLED DIXIN cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;Wnt signaling pathway#GO:0016055;signaling#GO:0023052;biological regulation#GO:0065007;cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;canonical Wnt signaling pathway#GO:0060070 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 scaffold/adaptor protein#PC00226 HUMAN|HGNC=4292|UniProtKB=Q14409 Q14409 GK3 PTHR10196:SF95 SUGAR KINASE GLYCEROL KINASE 3 transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;phosphotransferase activity, alcohol group as acceptor#GO:0016773 carbohydrate metabolic process#GO:0005975;small molecule metabolic process#GO:0044281;glycerolipid metabolic process#GO:0046486;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;organophosphate biosynthetic process#GO:0090407;biosynthetic process#GO:0009058;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;organophosphate metabolic process#GO:0019637;carbohydrate derivative biosynthetic process#GO:1901137;neutral lipid metabolic process#GO:0006638;triglyceride metabolic process#GO:0006641;lipid metabolic process#GO:0006629;alcohol metabolic process#GO:0006066;acylglycerol metabolic process#GO:0006639;metabolic process#GO:0008152 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 carbohydrate kinase#PC00065;kinase#PC00137 HUMAN|HGNC=8980|UniProtKB=O00459 O00459 PIK3R2 PTHR10155:SF1 PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;enzyme regulator activity#GO:0030234 regulation of biological process#GO:0050789;response to insulin#GO:0032868;cellular response to stimulus#GO:0051716;response to endogenous stimulus#GO:0009719;signaling#GO:0023052;cellular response to peptide hormone stimulus#GO:0071375;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cellular response to hormone stimulus#GO:0032870;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;response to oxygen-containing compound#GO:1901700;insulin receptor signaling pathway#GO:0008286;cellular response to chemical stimulus#GO:0070887;response to nitrogen compound#GO:1901698;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;cellular process#GO:0009987;response to hormone#GO:0009725;biological regulation#GO:0065007;response to peptide hormone#GO:0043434;response to chemical#GO:0042221;cellular response to nitrogen compound#GO:1901699;cellular response to insulin stimulus#GO:0032869;cell surface receptor signaling pathway#GO:0007166 membrane#GO:0016020;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494;transferase complex#GO:1990234;transferase complex, transferring phosphorus-containing groups#GO:0061695;extrinsic component of membrane#GO:0019898 kinase modulator#PC00140 Hypoxia response via HIF activation#P00030>PI3K#P00823;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>PI3K#P00900;PDGF signaling pathway#P00047>PI3K#P01168;Angiogenesis#P00005>PI3K#P00236;PI3 kinase pathway#P00048>p85#P01202;Endothelin signaling pathway#P00019>PI3K#P00577;p53 pathway#P00059>PI3K#P04609;Integrin signalling pathway#P00034>PI3K#P00936;Axon guidance mediated by netrin#P00009>PI3K#P00363;VEGF signaling pathway#P00056>PI3K#P01413;T cell activation#P00053>PI3K#P01322;p53 pathway feedback loops 2#P04398>PI3K#P04661 HUMAN|HGNC=2327|UniProtKB=O95639 O95639 CPSF4 PTHR23102:SF18 CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4-RELATED CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4 mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;mRNA 3'-end processing#GO:0031124;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA 3'-end processing#GO:0031123;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070 nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;mRNA cleavage factor complex#GO:0005849;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;mRNA cleavage and polyadenylation specificity factor complex#GO:0005847;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148 HUMAN|HGNC=14933|UniProtKB=Q9NXA8 Q9NXA8 SIRT5 PTHR11085:SF24 NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL deacetylase activity#GO:0019213;hydrolase activity#GO:0016787;histone modifying activity#GO:0140993;acyltransferase activity#GO:0016746;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;catalytic activity, acting on a protein#GO:0140096;NAD-dependent protein lysine deacetylase activity#GO:0034979;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;deacylase activity#GO:0160215;transferase activity#GO:0016740;histone deacetylase activity#GO:0004407;catalytic activity#GO:0003824 nucleus#GO:0005634;mitochondrion#GO:0005739;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=22030|UniProtKB=Q8N8M0 Q8N8M0 NAT16 PTHR47403:SF3 LOC100145250 PROTEIN N-ACETYLTRANSFERASE 16-RELATED HUMAN|HGNC=11772|UniProtKB=P36897 P36897 TGFBR1 PTHR23255:SF61 TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II TGF-BETA RECEPTOR TYPE-1 transmembrane receptor protein serine/threonine kinase activity#GO:0004675;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;protein kinase activity#GO:0004672;binding#GO:0005488;protein serine/threonine kinase activity#GO:0004674;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;transferase activity#GO:0016740;kinase activity#GO:0016301;activin binding#GO:0048185;transforming growth factor beta receptor activity#GO:0005024;molecular transducer activity#GO:0060089;catalytic activity, acting on a protein#GO:0140096;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772 developmental process#GO:0032502;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;system development#GO:0048731;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;cell population proliferation#GO:0008283;response to transforming growth factor beta#GO:0071559;response to growth factor#GO:0070848;regulation of cellular process#GO:0050794;cellular response to transforming growth factor beta stimulus#GO:0071560;cellular response to stimulus#GO:0051716;multicellular organism development#GO:0007275;endothelial cell proliferation#GO:0001935;epithelial cell proliferation#GO:0050673;animal organ development#GO:0048513;cell surface receptor signaling pathway#GO:0007166;nervous system development#GO:0007399;heart development#GO:0007507;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;signal transduction#GO:0007165;cellular process#GO:0009987;transforming growth factor beta receptor signaling pathway#GO:0007179;cellular response to growth factor stimulus#GO:0071363;activin receptor signaling pathway#GO:0032924;animal gross anatomical part developmental process#GO:0160108;signaling#GO:0023052;response to stimulus#GO:0050896;circulatory system development#GO:0072359;cellular response to endogenous stimulus#GO:0071495;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719 signaling receptor complex#GO:0043235;catalytic complex#GO:1902494;transferase complex#GO:1990234;transferase complex, transferring phosphorus-containing groups#GO:0061695;protein kinase complex#GO:1902911;serine/threonine protein kinase complex#GO:1902554;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 serine/threonine protein kinase receptor#PC00205 Wnt signaling pathway#P00057>TGFbetaactivated Kinase-1#P01442;TGF-beta signaling pathway#P00052>TGFbetareceptors#P01283;TGF-beta signaling pathway#P00052>TGFbetareceptor I#P01278 HUMAN|HGNC=16405|UniProtKB=O43709 O43709 BUD23 PTHR12734:SF0 METHYLTRANSFERASE-RELATED 18S RRNA (GUANINE-N(7))-METHYLTRANSFERASE methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;catalytic activity, acting on a rRNA#GO:0140102;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a nucleic acid#GO:0140640;rRNA methyltransferase activity#GO:0008649;RNA methyltransferase activity#GO:0008173;rRNA (guanine) methyltransferase activity#GO:0016435;catalytic activity, acting on RNA#GO:0140098 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;nucleocytoplasmic transport#GO:0006913;ribosomal small subunit export from nucleus#GO:0000056;ribosome localization#GO:0033750;organelle localization#GO:0051640;nuclear export#GO:0051168;rRNA processing#GO:0006364;nuclear transport#GO:0051169;localization#GO:0051179;macromolecule biosynthetic process#GO:0009059;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;transport#GO:0006810;intracellular transport#GO:0046907;rRNA metabolic process#GO:0016072;ribosomal subunit export from nucleus#GO:0000054;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;ribonucleoprotein complex biogenesis#GO:0022613;establishment of organelle localization#GO:0051656;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;RNA metabolic process#GO:0016070;cellular localization#GO:0051641;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;cellular component biogenesis#GO:0044085;RNA processing#GO:0006396;gene expression#GO:0010467;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165 methyltransferase#PC00155;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=7597|UniProtKB=O00159 O00159 MYO1C PTHR13140:SF255 MYOSIN UNCONVENTIONAL MYOSIN-IC isomerase activity#GO:0016853;cytoskeletal motor activity#GO:0003774;macromolecular conformation isomerase activity#GO:0120543;ATP-dependent activity#GO:0140657;polypeptide conformation or assembly isomerase activity#GO:0120544;catalytic activity#GO:0003824;microfilament motor activity#GO:0000146 organelle organization#GO:0006996;cellular component organization#GO:0016043;actin filament-based movement#GO:0030048;cellular process#GO:0009987;actin cytoskeleton organization#GO:0030036;endocytosis#GO:0006897;cytoskeleton organization#GO:0007010;actin filament-based process#GO:0030029;transport#GO:0006810;cellular component organization or biogenesis#GO:0071840;localization#GO:0051179;import into cell#GO:0098657;establishment of localization#GO:0051234;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015 cell periphery#GO:0071944;membrane#GO:0016020;cytoplasm#GO:0005737;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;microvillus#GO:0005902;actin-based cell projection#GO:0098858;actin cytoskeleton#GO:0015629;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 actin binding motor protein#PC00040 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HUMAN|HGNC=6775|UniProtKB=O95405 O95405 ZFYVE9 PTHR46319:SF2 ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 9 biological regulation#GO:0065007;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;vesicle-mediated transport#GO:0016192;signal transduction#GO:0007165;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;transforming growth factor beta receptor signaling pathway#GO:0007179;endosomal transport#GO:0016197;establishment of localization#GO:0051234;transport#GO:0006810;cell surface receptor signaling pathway#GO:0007166;intracellular transport#GO:0046907;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;signaling#GO:0023052;cellular response to endogenous stimulus#GO:0071495;response to growth factor#GO:0070848;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to transforming growth factor beta stimulus#GO:0071560;cellular response to stimulus#GO:0051716;response to endogenous stimulus#GO:0009719;cellular response to growth factor stimulus#GO:0071363;localization#GO:0051179;cell communication#GO:0007154;cellular localization#GO:0051641;enzyme-linked receptor protein signaling pathway#GO:0007167;response to transforming growth factor beta#GO:0071559 vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endosome#GO:0005768;endosome membrane#GO:0010008;membrane-bounded organelle#GO:0043227;early endosome#GO:0005769;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;vesicle membrane#GO:0012506;membrane#GO:0016020;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;early endosome membrane#GO:0031901;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588 TGF-beta signaling pathway#P00052>SARA#P01281 HUMAN|HGNC=18896|UniProtKB=Q9H7F4 Q9H7F4 TMEM185B PTHR13568:SF5 FAM11A, B PROTEIN TRANSMEMBRANE PROTEIN 185B HUMAN|HGNC=18401|UniProtKB=Q9H4P4 Q9H4P4 RNF41 PTHR15315:SF122 RING FINGER PROTEIN 41, 151 E3 UBIQUITIN-PROTEIN LIGASE NRDP1 ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824 protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238;catabolic process#GO:0009056 endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;endoplasmic reticulum tubular network#GO:0071782;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=13709|UniProtKB=O15121 O15121 DEGS1 PTHR12879:SF2 SPHINGOLIPID DELTA 4 DESATURASE/C-4 HYDROXYLASE PROTEIN DES2 SPHINGOLIPID DELTA(4)-DESATURASE DES1 catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;oxidoreductase activity#GO:0016491 cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;lipid metabolic process#GO:0006629;ceramide biosynthetic process#GO:0046513;sphingolipid biosynthetic process#GO:0030148;metabolic process#GO:0008152;sphingolipid metabolic process#GO:0006665;ceramide metabolic process#GO:0006672 hydroxylase#PC00122;oxidoreductase#PC00176 HUMAN|HGNC=23627|UniProtKB=Q86SP6 Q86SP6 GPR149 PTHR24229:SF32 NEUROPEPTIDES RECEPTOR G PROTEIN-COUPLED RECEPTOR 149-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;neuropeptide binding#GO:0042923;peptide binding#GO:0042277;transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;neuropeptide signaling pathway#GO:0007218;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052 cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005 G-protein coupled receptor#PC00021 HUMAN|HGNC=8708|UniProtKB=Q9Y5G3 Q9Y5G3 PCDHGB1 PTHR24028:SF73 CADHERIN-87A PROTOCADHERIN GAMMA-B1 cellular process#GO:0009987;cell adhesion#GO:0007155 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 cadherin#PC00057;cell adhesion molecule#PC00069 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HUMAN|HGNC=9999|UniProtKB=P49796 P49796 RGS3 PTHR46848:SF1 REGULATOR OF G-PROTEIN SIGNALING 3 REGULATOR OF G PROTEIN SIGNALING 3 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>RGS#P00704;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>RGS#P00731 HUMAN|HGNC=14141|UniProtKB=Q96S19 Q96S19 METTL26 PTHR20974:SF2 UPF0585 PROTEIN CG18661 METHYLTRANSFERASE-LIKE 26 HUMAN|HGNC=18234|UniProtKB=Q96EN8 Q96EN8 MOCOS PTHR14237:SF96 MOLYBDOPTERIN COFACTOR SULFURASE MOSC MOLYBDENUM COFACTOR SULFURASE sulfurtransferase activity#GO:0016783;transferase activity, transferring sulphur-containing groups#GO:0016782;catalytic activity#GO:0003824;transferase activity#GO:0016740 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;cellular process#GO:0009987;metabolic process#GO:0008152;organophosphate metabolic process#GO:0019637;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238 HUMAN|HGNC=24380|UniProtKB=Q6YFQ2 Q6YFQ2 COX6B2 PTHR11387:SF12 CYTOCHROME C OXIDASE SUBUNIT 6B CYTOCHROME C OXIDASE SUBUNIT 6B2 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 oxidoreductase#PC00176;oxidase#PC00175 HUMAN|HGNC=6353|UniProtKB=O95198 O95198 KLHL2 PTHR24412:SF155 KELCH PROTEIN KELCH-LIKE PROTEIN 2 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;enzyme-substrate adaptor activity#GO:0140767;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498 cytoplasm#GO:0005737;cullin-RING ubiquitin ligase complex#GO:0031461;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;ubiquitin ligase complex#GO:0000151;Cul3-RING ubiquitin ligase complex#GO:0031463;catalytic complex#GO:1902494;transferase complex#GO:1990234 scaffold/adaptor protein#PC00226 HUMAN|HGNC=16243|UniProtKB=Q9H1R3 Q9H1R3 MYLK2 PTHR24347:SF373 SERINE/THREONINE-PROTEIN KINASE MYOSIN LIGHT CHAIN KINASE 2, SKELETAL_CARDIAC MUSCLE protein binding#GO:0005515;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;binding#GO:0005488;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;myosin binding#GO:0017022;cytoskeletal protein binding#GO:0008092;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 heart morphogenesis#GO:0003007;cellular response to stimulus#GO:0051716;striated muscle contraction#GO:0006941;animal organ morphogenesis#GO:0009887;regulation of cellular process#GO:0050794;muscle structure development#GO:0061061;muscle tissue development#GO:0060537;system development#GO:0048731;tissue morphogenesis#GO:0048729;cell communication#GO:0007154;anatomical structure development#GO:0048856;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;tissue development#GO:0009888;muscle contraction#GO:0006936;developmental process#GO:0032502;system process#GO:0003008;cardiac muscle tissue development#GO:0048738;regulation of biological process#GO:0050789;muscle system process#GO:0003012;anatomical structure morphogenesis#GO:0009653;signaling#GO:0023052;response to stimulus#GO:0050896;circulatory system development#GO:0072359;animal gross anatomical part developmental process#GO:0160108;signal transduction#GO:0007165;cellular process#GO:0009987;heart development#GO:0007507;striated muscle tissue development#GO:0014706;muscle organ development#GO:0007517;multicellular organism development#GO:0007275;animal organ development#GO:0048513 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>MLCK#P00877;Cytoskeletal regulation by Rho GTPase#P00016>MLCK#P00514 HUMAN|HGNC=19597|UniProtKB=Q9H2C8 Q9H2C8 OR51V1 PTHR26450:SF67 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 51V1 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=8485|UniProtKB=Q6IF36 Q6IF36 OR8G2P PTHR48018:SF27 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 8G2 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 multicellular organismal process#GO:0032501;biological regulation#GO:0065007;signal transduction#GO:0007165;cellular process#GO:0009987;system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606;response to stimulus#GO:0050896;sensory perception of smell#GO:0007608;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;sensory perception#GO:0007600;nervous system process#GO:0050877 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=18231|UniProtKB=Q9BYE9 Q9BYE9 CDHR2 PTHR24026:SF133 FAT ATYPICAL CADHERIN-RELATED CADHERIN-RELATED FAMILY MEMBER 2 axon development#GO:0061564;epithelium development#GO:0060429;tissue development#GO:0009888;multicellular organismal process#GO:0032501;epithelial cell differentiation#GO:0030855;plasma membrane bounded cell projection organization#GO:0120036;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;anatomical structure development#GO:0048856;system development#GO:0048731;neuron projection development#GO:0031175;cell-cell adhesion#GO:0098609;cellular process#GO:0009987;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cell projection morphogenesis#GO:0048858;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell morphogenesis#GO:0000902;cell development#GO:0048468;animal gross anatomical part developmental process#GO:0160108;cell adhesion#GO:0007155;generation of neurons#GO:0048699;axonogenesis#GO:0007409;neuron development#GO:0048666 cell-cell junction#GO:0005911;adherens junction#GO:0005912;anchoring junction#GO:0070161;cell junction#GO:0030054;cellular anatomical structure#GO:0110165 cadherin#PC00057 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HUMAN|HGNC=22972|UniProtKB=P60014 P60014 KRTAP10-10 PTHR23262:SF250 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 10-10 structural protein#PC00211 HUMAN|HGNC=9603|UniProtKB=Q16647 Q16647 PTGIS PTHR24306:SF4 FAMILY NOT NAMED PROSTACYCLIN SYNTHASE isomerase activity#GO:0016853;intramolecular oxidoreductase activity#GO:0016860;catalytic activity#GO:0003824 small molecule metabolic process#GO:0044281;carboxylic acid biosynthetic process#GO:0046394;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;prostaglandin metabolic process#GO:0006693;oxoacid metabolic process#GO:0043436;biosynthetic process#GO:0009058;icosanoid biosynthetic process#GO:0046456;fatty acid biosynthetic process#GO:0006633;unsaturated fatty acid biosynthetic process#GO:0006636;lipid biosynthetic process#GO:0008610;icosanoid metabolic process#GO:0006690;cellular process#GO:0009987;monocarboxylic acid biosynthetic process#GO:0072330;unsaturated fatty acid metabolic process#GO:0033559;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631 HUMAN|HGNC=16166|UniProtKB=Q96LM9 Q96LM9 C20orf173 PTHR46032:SF7 ALPHA-2,3-SIALYLTRANSFERASE ST3GAL I ISOFORM X1 RIKEN CDNA 6430550D23 GENE sialyltransferase activity#GO:0008373;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;transferase activity#GO:0016740 biosynthetic process#GO:0009058;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;macromolecule modification#GO:0043412;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152 membrane#GO:0016020;cellular anatomical structure#GO:0110165 transferase#PC00220 HUMAN|HGNC=7106|UniProtKB=P54252 P54252 ATXN3 PTHR14159:SF0 ATAXIN-3-RELATED ATAXIN-3-RELATED ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;cysteine-type deubiquitinase activity#GO:0004843;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005 metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;negative regulation of TORC1 signaling#GO:1904262;regulation of protein metabolic process#GO:0051246;positive regulation of biological process#GO:0048518;regulation of TOR signaling#GO:0032006;cellular process#GO:0009987;regulation of proteasomal protein catabolic process#GO:0061136;positive regulation of macromolecule metabolic process#GO:0010604;proteasomal protein catabolic process#GO:0010498;negative regulation of signal transduction#GO:0009968;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;protein catabolic process#GO:0030163;regulation of signaling#GO:0023051;positive regulation of protein metabolic process#GO:0051247;modification-dependent macromolecule catabolic process#GO:0043632;positive regulation of metabolic process#GO:0009893;negative regulation of intracellular signal transduction#GO:1902532;regulation of cellular response to stress#GO:0080135;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;positive regulation of proteasomal protein catabolic process#GO:1901800;regulation of biological process#GO:0050789;regulation of response to stress#GO:0080134;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;macromolecule metabolic process#GO:0043170;positive regulation of catabolic process#GO:0009896;regulation of TORC1 signaling#GO:1903432;ubiquitin-dependent protein catabolic process#GO:0006511;regulation of catabolic process#GO:0009894;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;positive regulation of response to stimulus#GO:0048584;negative regulation of response to stimulus#GO:0048585;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;protein metabolic process#GO:0019538;positive regulation of protein catabolic process#GO:0045732;regulation of protein catabolic process#GO:0042176;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;regulation of response to endoplasmic reticulum stress#GO:1905897;catabolic process#GO:0009056;protein quality control for misfolded or incompletely synthesized proteins#GO:0006515;regulation of macromolecule metabolic process#GO:0060255;negative regulation of TOR signaling#GO:0032007;regulation of cellular process#GO:0050794;regulation of ERAD pathway#GO:1904292;regulation of cell communication#GO:0010646 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=9722|UniProtKB=P54886 P54886 ALDH18A1 PTHR11063:SF28 GLUTAMATE SEMIALDEHYDE DEHYDROGENASE DELTA-1-PYRROLINE-5-CARBOXYLATE SYNTHASE catalytic activity#GO:0003824;oxidoreductase activity, acting on the aldehyde or oxo group of donors#GO:0016903;oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor#GO:0016620;oxidoreductase activity#GO:0016491 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=5991|UniProtKB=P01583 P01583 IL1A PTHR10078:SF33 INTERLEUKIN-1 FAMILY MEMBER INTERLEUKIN-1 ALPHA receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;cytokine activity#GO:0005125;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772 response to lipopolysaccharide#GO:0032496;positive regulation of mononuclear cell proliferation#GO:0032946;regulation of leukocyte proliferation#GO:0070663;cellular process#GO:0009987;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;positive regulation of biological process#GO:0048518;regulation of mononuclear cell proliferation#GO:0032944;positive regulation of immune system process#GO:0002684;response to biotic stimulus#GO:0009607;cellular response to lipid#GO:0071396;regulation of ERK1 and ERK2 cascade#GO:0070372;regulation of signaling#GO:0023051;cellular response to chemical stimulus#GO:0070887;immune system process#GO:0002376;positive regulation of multicellular organismal process#GO:0051240;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;response to molecule of bacterial origin#GO:0002237;response to stimulus#GO:0050896;regulation of response to stimulus#GO:0048583;positive regulation of leukocyte proliferation#GO:0070665;defense response#GO:0006952;regulation of canonical NF-kappaB signal transduction#GO:0043122;positive regulation of cellular process#GO:0048522;immune response#GO:0006955;positive regulation of cell activation#GO:0050867;positive regulation of leukocyte cell-cell adhesion#GO:1903039;biological regulation#GO:0065007;regulation of lymphocyte proliferation#GO:0050670;regulation of cell adhesion#GO:0030155;positive regulation of response to stimulus#GO:0048584;cytokine-mediated signaling pathway#GO:0019221;regulation of cell population proliferation#GO:0042127;positive regulation of lymphocyte activation#GO:0051251;cellular response to stimulus#GO:0051716;cellular response to biotic stimulus#GO:0071216;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;regulation of cell-cell adhesion#GO:0022407;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of T cell proliferation#GO:0042129;cell surface receptor signaling pathway#GO:0007166;positive regulation of leukocyte activation#GO:0002696;regulation of MAPK cascade#GO:0043408;positive regulation of canonical NF-kappaB signal transduction#GO:0043123;response to stress#GO:0006950;cellular response to lipopolysaccharide#GO:0071222;positive regulation of cell-cell adhesion#GO:0022409;regulation of multicellular organismal process#GO:0051239;response to lipid#GO:0033993;regulation of T cell activation#GO:0050863;response to cytokine#GO:0034097;response to chemical#GO:0042221;positive regulation of T cell activation#GO:0050870;response to oxygen-containing compound#GO:1901700;regulation of intracellular signal transduction#GO:1902531;response to peptide#GO:1901652;positive regulation of signaling#GO:0023056;regulation of cell activation#GO:0050865;regulation of leukocyte activation#GO:0002694;positive regulation of cell population proliferation#GO:0008284;regulation of lymphocyte activation#GO:0051249;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;positive regulation of T cell proliferation#GO:0042102;positive regulation of intracellular signal transduction#GO:1902533;regulation of leukocyte cell-cell adhesion#GO:1903037;response to external stimulus#GO:0009605;cellular response to molecule of bacterial origin#GO:0071219;response to other organism#GO:0051707;regulation of signal transduction#GO:0009966;positive regulation of lymphocyte proliferation#GO:0050671;inflammatory response#GO:0006954;response to bacterium#GO:0009617;cell communication#GO:0007154;positive regulation of cell adhesion#GO:0045785;response to external biotic stimulus#GO:0043207;positive regulation of cell communication#GO:0010647 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207;cytokine#PC00083;interleukin superfamily#PC00128 Interleukin signaling pathway#P00036>Interleukin#P00970;Interleukin signaling pathway#P00036>Receptor subunit alpha#P00992 HUMAN|HGNC=962|UniProtKB=Q9UIF9 Q9UIF9 BAZ2A PTHR45915:SF5 TRANSCRIPTION INTERMEDIARY FACTOR BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 2A chromatin-protein adaptor activity#GO:0140463;transcription regulator activity#GO:0140110;molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;protein-macromolecule adaptor activity#GO:0030674 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;epigenetic regulation of gene expression#GO:0040029;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;chromatin organization#GO:0006325;negative regulation of biosynthetic process#GO:0009890;negative regulation of cellular process#GO:0048523;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;heterochromatin formation#GO:0031507;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cellular component assembly#GO:0022607;heterochromatin organization#GO:0070828;cellular component organization or biogenesis#GO:0071840;negative regulation of gene expression, epigenetic#GO:0045814;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338 chromosome#GO:0005694;SWI/SNF superfamily-type complex#GO:0070603;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ATPase complex#GO:1904949;ISWI-type complex#GO:0031010;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;chromatin#GO:0000785;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;nuclear protein-containing complex#GO:0140513;heterochromatin#GO:0000792;membraneless organelle#GO:0043228 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=16882|UniProtKB=Q9Y3Q4 Q9Y3Q4 HCN4 PTHR45689:SF4 I[[H]] CHANNEL, ISOFORM E POTASSIUM_SODIUM HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNEL 4 potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;potassium channel activity#GO:0005267;monoatomic cation channel activity#GO:0005261;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated monoatomic ion channel activity#GO:0005244;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;transporter activity#GO:0005215 sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;potassium ion transport#GO:0006813;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;regulation of biological process#GO:0050789;sodium ion transport#GO:0006814;regulation of cellular process#GO:0050794;metal ion transport#GO:0030001;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008 neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;cation channel complex#GO:0034703;voltage-gated potassium channel complex#GO:0008076;transporter complex#GO:1990351;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165;axon#GO:0030424;dendritic tree#GO:0097447;dendrite#GO:0030425;transmembrane transporter complex#GO:1902495 ion channel#PC00133;transporter#PC00227 HUMAN|HGNC=12970|UniProtKB=Q9UJW8 Q9UJW8 ZNF180 PTHR24381:SF27 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 180 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=5987|UniProtKB=O95998 O95998 IL18BP PTHR14292:SF2 INTERLEUKIN-18-BINDING PROTEIN INTERLEUKIN-18-BINDING PROTEIN cytokine binding#GO:0019955;protein binding#GO:0005515;binding#GO:0005488 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;adaptive immune response#GO:0002250;response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 extracellular region#GO:0005576;signaling receptor complex#GO:0043235;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 HUMAN|HGNC=3620|UniProtKB=O75015 O75015 FCGR3B PTHR11481:SF103 IMMUNOGLOBULIN FC RECEPTOR LOW AFFINITY IMMUNOGLOBULIN GAMMA FC REGION RECEPTOR III-A-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;immune system process#GO:0002376;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;cell communication#GO:0007154;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;cellular process#GO:0009987;immune response#GO:0006955;signal transduction#GO:0007165;adaptive immune response#GO:0002250;biological regulation#GO:0065007;immune effector process#GO:0002252;cell surface receptor signaling pathway#GO:0007166 cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell surface#GO:0009986;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=28031|UniProtKB=Q6PGQ1 Q6PGQ1 DRICH1 PTHR15880:SF0 ASPARTATE-RICH PROTEIN 1 ASPARTATE-RICH PROTEIN 1 HUMAN|HGNC=7670|UniProtKB=Q9Y6Q9 Q9Y6Q9 NCOA3 PTHR10684:SF3 NUCLEAR RECEPTOR COACTIVATOR NUCLEAR RECEPTOR COACTIVATOR 3 binding#GO:0005488;transcription regulator activity#GO:0140110;protein binding#GO:0005515;RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629;DNA-binding transcription factor binding#GO:0140297;transcription coregulator activity#GO:0003712;transcription factor binding#GO:0008134;nuclear receptor binding#GO:0016922;transcription coactivator activity#GO:0003713 response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;cellular response to hormone stimulus#GO:0032870;cellular response to chemical stimulus#GO:0070887;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;response to hormone#GO:0009725;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;response to chemical#GO:0042221;positive regulation of transcription by RNA polymerase II#GO:0045944;cellular response to stimulus#GO:0051716;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of cellular process#GO:0048522;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 histone modifying enzyme#PC00261 Gonadotropin-releasing hormone receptor pathway#P06664>Ncoa3#P06719 HUMAN|HGNC=13095|UniProtKB=P17041 P17041 ZNF32 PTHR23226:SF214 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER PROTEIN 32 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=5129|UniProtKB=P31273 P31273 HOXC8 PTHR46166:SF4 HOMEOBOX DOMAIN-CONTAINING PROTEIN HOMEOBOX PROTEIN HOX-C8 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 homeodomain transcription factor#PC00119 HUMAN|HGNC=10817|UniProtKB=O95470 O95470 SGPL1 PTHR42735:SF6 FAMILY NOT NAMED SPHINGOSINE-1-PHOSPHATE LYASE 1 catalytic activity#GO:0003824;carbon-carbon lyase activity#GO:0016830;lyase activity#GO:0016829;aldehyde-lyase activity#GO:0016832 metabolic process#GO:0008152;sphingolipid metabolic process#GO:0006665;lipid metabolic process#GO:0006629;catabolic process#GO:0009056;sphingolipid catabolic process#GO:0030149;primary metabolic process#GO:0044238;lipid catabolic process#GO:0016042;cellular process#GO:0009987 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 HUMAN|HGNC=14438|UniProtKB=Q53TS8 Q53TS8 CATSPERT PTHR21665:SF2 CATION CHANNEL SPERM-ASSOCIATED TARGETING SUBUNIT TAU CATION CHANNEL SPERM-ASSOCIATED TARGETING SUBUNIT TAU HUMAN|HGNC=6510|UniProtKB=P16949 P16949 STMN1 PTHR10104:SF5 STATHMIN STATHMIN binding#GO:0005488;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;protein binding#GO:0005515 microtubule depolymerization#GO:0007019;cytoskeleton organization#GO:0007010;regulation of microtubule cytoskeleton organization#GO:0070507;nervous system development#GO:0007399;neuron projection development#GO:0031175;organelle organization#GO:0006996;cellular process#GO:0009987;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;protein-containing complex organization#GO:0043933;neuron differentiation#GO:0030182;regulation of cellular component organization#GO:0051128;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell development#GO:0048468;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;cellular component disassembly#GO:0022411;neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;protein depolymerization#GO:0051261;microtubule polymerization or depolymerization#GO:0031109;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;regulation of microtubule polymerization or depolymerization#GO:0031110;developmental process#GO:0032502;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794;protein-containing complex disassembly#GO:0032984;microtubule cytoskeleton organization#GO:0000226;anatomical structure development#GO:0048856;system development#GO:0048731;supramolecular fiber organization#GO:0097435;regulation of microtubule-based process#GO:0032886 neuron projection#GO:0043005;cell projection#GO:0042995;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 non-motor microtubule binding protein#PC00166;microtubule or microtubule-binding cytoskeletal protein#PC00157 Cytoskeletal regulation by Rho GTPase#P00016>Op18/stathmin#P00513 HUMAN|HGNC=3534|UniProtKB=P05160 P05160 F13B PTHR45785:SF3 COMPLEMENT FACTOR H-RELATED COAGULATION FACTOR XIII B CHAIN regulation of biological quality#GO:0065008;wound healing#GO:0042060;blood coagulation#GO:0007596;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regulation of body fluid levels#GO:0050878;response to stimulus#GO:0050896;coagulation#GO:0050817;response to stress#GO:0006950;response to wounding#GO:0009611;hemostasis#GO:0007599 complement component#PC00078 Blood coagulation#P00011>FXIII#P00453;Vitamin D metabolism and pathway#P04396>RXR#P04602;Blood coagulation#P00011>FXIIIa#P00419 HUMAN|HGNC=22945|UniProtKB=P59045 P59045 NLRP11 PTHR45690:SF5 NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12 NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 11 regulation of response to external stimulus#GO:0032101;biological regulation#GO:0065007;regulation of response to stress#GO:0080134;regulation of biological process#GO:0050789;regulation of defense response#GO:0031347;regulation of inflammatory response#GO:0050727;regulation of response to stimulus#GO:0048583 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090 HUMAN|HGNC=24025|UniProtKB=Q9GZN1 Q9GZN1 ACTR6 PTHR11937:SF47 ACTIN ACTIN-RELATED PROTEIN 6 protein-containing complex binding#GO:0044877;structural molecule activity#GO:0005198;nucleosome binding#GO:0031491;chromatin binding#GO:0003682;binding#GO:0005488;structural constituent of cytoskeleton#GO:0005200 cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;chromatin remodeling#GO:0006338;chromatin organization#GO:0006325;nucleolus organization#GO:0007000;nucleus organization#GO:0006997;cellular component organization or biogenesis#GO:0071840 membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;protein-containing complex#GO:0032991;nucleus#GO:0005634;chromatin#GO:0000785;membrane-enclosed lumen#GO:0031974;histone deacetylase complex#GO:0000118;intracellular anatomical structure#GO:0005622;INO80-type complex#GO:0097346;membrane-bounded organelle#GO:0043227;ATPase complex#GO:1904949;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;Swr1 complex#GO:0000812;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;SWI/SNF superfamily-type complex#GO:0070603;chromosome#GO:0005694;organelle lumen#GO:0043233 actin and actin related protein#PC00039 HUMAN|HGNC=38842|UniProtKB=B3KU38 B3KU38 IQCJ-SCHIP1 PTHR13103:SF2 SCHWANNOMIN INTERACTING PROTEIN 1 IQCJ-SCHIP1 READTHROUGH TRANSCRIPT PROTEIN-RELATED positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;positive regulation of signaling#GO:0023056;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;regulation of hippo signaling#GO:0035330;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell junction#GO:0030054;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=4616|UniProtKB=P49840 P49840 GSK3A PTHR24057:SF14 GLYCOGEN SYNTHASE KINASE-3 ALPHA GLYCOGEN SYNTHASE KINASE-3 ALPHA kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 regulation of signal transduction#GO:0009966;cellular response to nitrogen compound#GO:1901699;negative regulation of Wnt signaling pathway#GO:0030178;developmental process#GO:0032502;cellular developmental process#GO:0048869;positive regulation of ubiquitin-dependent protein catabolic process#GO:2000060;cellular response to peptide hormone stimulus#GO:0071375;negative regulation of TOR signaling#GO:0032007;regulation of cytoskeleton organization#GO:0051493;positive regulation of protein catabolic process#GO:0045732;response to nitrogen compound#GO:1901698;regulation of protein catabolic process#GO:0042176;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of TOR signaling#GO:0032006;positive regulation of autophagy#GO:0010508;regulation of neuron apoptotic process#GO:0043523;regulation of protein metabolic process#GO:0051246;response to hormone#GO:0009725;regulation of microtubule cytoskeleton organization#GO:0070507;response to chemical#GO:0042221;cell surface receptor signaling pathway#GO:0007166;regulation of apoptotic process#GO:0042981;positive regulation of apoptotic process#GO:0043065;response to endogenous stimulus#GO:0009719;regulation of programmed cell death#GO:0043067;positive regulation of proteasomal protein catabolic process#GO:1901800;signaling#GO:0023052;cellular response to endogenous stimulus#GO:0071495;cell differentiation#GO:0030154;positive regulation of programmed cell death#GO:0043068;response to oxygen-containing compound#GO:1901700;positive regulation of protein metabolic process#GO:0051247;negative regulation of canonical Wnt signaling pathway#GO:0090090;regulation of intracellular signal transduction#GO:1902531;positive regulation of metabolic process#GO:0009893;negative regulation of intracellular signal transduction#GO:1902532;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;response to peptide hormone#GO:0043434;negative regulation of response to stimulus#GO:0048585;cellular response to insulin stimulus#GO:0032869;regulation of response to stimulus#GO:0048583;positive regulation of neuron apoptotic process#GO:0043525;regulation of cell projection organization#GO:0031344;negative regulation of cellular process#GO:0048523;regulation of catabolic process#GO:0009894;regulation of plasma membrane bounded cell projection organization#GO:0120035;positive regulation of catabolic process#GO:0009896;cellular response to stimulus#GO:0051716;response to insulin#GO:0032868;regulation of cell communication#GO:0010646;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of microtubule-based process#GO:0032886;positive regulation of biological process#GO:0048518;regulation of neuron projection development#GO:0010975;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of canonical Wnt signaling pathway#GO:0060828;positive regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032436;negative regulation of signal transduction#GO:0009968;regulation of proteasomal protein catabolic process#GO:0061136;positive regulation of macromolecule metabolic process#GO:0010604;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;negative regulation of biological process#GO:0048519;regulation of autophagy#GO:0010506;regulation of Wnt signaling pathway#GO:0030111;response to stimulus#GO:0050896;regulation of cellular component organization#GO:0051128;cellular response to hormone stimulus#GO:0032870;insulin receptor signaling pathway#GO:0008286;regulation of signaling#GO:0023051;cellular response to chemical stimulus#GO:0070887;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;dendritic tree#GO:0097447;axon#GO:0030424;dendrite#GO:0030425;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;somatodendritic compartment#GO:0036477;nucleus#GO:0005634;neuron projection#GO:0043005;cytosol#GO:0005829 non-receptor serine/threonine protein kinase#PC00167 Ras Pathway#P04393>GSK3#P04546;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GSK#P00714;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>GSK-3#P00902;PDGF signaling pathway#P00047>GSK3#P01153 HUMAN|HGNC=16183|UniProtKB=Q9H426 Q9H426 RIMS4 PTHR12157:SF28 REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN 4 structural constituent of synapse#GO:0098918;structural molecule activity#GO:0005198 transport#GO:0006810;synaptic vesicle cycle#GO:0099504;establishment of localization#GO:0051234;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;neurotransmitter secretion#GO:0007269;signal release#GO:0023061;trans-synaptic signaling#GO:0099537;regulation of exocytosis#GO:0017157;cell communication#GO:0007154;localization#GO:0051179;regulation of secretion#GO:0051046;secretion#GO:0046903;signal release from synapse#GO:0099643;chemical synaptic transmission#GO:0007268;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;exocytic process#GO:0140029;regulated exocytosis#GO:0045055;exocytosis#GO:0006887;regulation of localization#GO:0032879;regulation of transport#GO:0051049;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;vesicle-mediated transport in synapse#GO:0099003;establishment of localization in cell#GO:0051649;synaptic vesicle exocytosis#GO:0016079;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;synaptic signaling#GO:0099536;neurotransmitter transport#GO:0006836;cellular component assembly#GO:0022607;vesicle-mediated transport#GO:0016192;regulation of trans-synaptic signaling#GO:0099177;regulation of signaling#GO:0023051;regulation of neurotransmitter transport#GO:0051588;secretion by cell#GO:0032940;regulation of secretion by cell#GO:1903530;cellular localization#GO:0051641;protein-containing complex assembly#GO:0065003;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;cellular component organization#GO:0016043;export from cell#GO:0140352;signaling#GO:0023052;regulation of synaptic vesicle exocytosis#GO:2000300;regulation of neurotransmitter secretion#GO:0046928 intracellular anatomical structure#GO:0005622;cell junction#GO:0030054;presynaptic active zone#GO:0048786;synaptic membrane#GO:0097060;plasma membrane#GO:0005886;presynaptic membrane#GO:0042734;cytoplasm#GO:0005737;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;synapse#GO:0045202;cell cortex#GO:0005938;presynapse#GO:0098793;cell periphery#GO:0071944;membrane#GO:0016020 membrane traffic protein#PC00150 HUMAN|HGNC=18043|UniProtKB=Q7L590 Q7L590 MCM10 PTHR13454:SF11 PROTEIN MCM10 HOMOLOG PROTEIN MCM10 HOMOLOG DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA replication origin binding#GO:0003688;single-stranded DNA binding#GO:0003697;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 DNA replication#GO:0006260;cellular process#GO:0009987;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;nucleobase-containing compound metabolic process#GO:0006139;DNA replication initiation#GO:0006270;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;DNA-templated DNA replication#GO:0006261 membraneless organelle#GO:0043228;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nuclear replication fork#GO:0043596;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;replication fork#GO:0005657;organelle lumen#GO:0043233;chromosome#GO:0005694 HUMAN|HGNC=550|UniProtKB=Q16853 Q16853 AOC3 PTHR10638:SF23 COPPER AMINE OXIDASE AMINE OXIDASE [COPPER-CONTAINING] 3 binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;transition metal ion binding#GO:0046914;metal ion binding#GO:0046872;cation binding#GO:0043169;catalytic activity#GO:0003824;copper ion binding#GO:0005507;oxidoreductase activity#GO:0016491 cellular process#GO:0009987;amine metabolic process#GO:0009308;metabolic process#GO:0008152 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;membrane-bounded organelle#GO:0043227;early endosome#GO:0005769;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endosome#GO:0005768;endomembrane system#GO:0012505;plasma membrane#GO:0005886;cytoplasm#GO:0005737;membrane#GO:0016020;cell periphery#GO:0071944;Golgi apparatus#GO:0005794;endoplasmic reticulum#GO:0005783 oxidoreductase#PC00176;oxidase#PC00175 Phenylethylamine degradation#P02766>Phenylethylamine oxidase#P03103 HUMAN|HGNC=29305|UniProtKB=Q96CP6 Q96CP6 GRAMD1A PTHR23319:SF8 GRAM DOMAIN CONTAINING 1B, ISOFORM E PROTEIN ASTER-A sterol binding#GO:0032934;lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104;small molecule binding#GO:0036094;binding#GO:0005488;cholesterol binding#GO:0015485;lipid transfer activity#GO:0120013;lipid binding#GO:0008289;sterol transfer activity#GO:0120015;transporter activity#GO:0005215;steroid binding#GO:0005496;cholesterol transfer activity#GO:0120020;alcohol binding#GO:0043178 lipid transport#GO:0006869;intracellular sterol transport#GO:0032366;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of localization#GO:0051234;cellular localization#GO:0051641;sterol transport#GO:0015918;localization#GO:0051179;organic hydroxy compound transport#GO:0015850;intracellular transport#GO:0046907;lipid localization#GO:0010876;transport#GO:0006810 endomembrane system#GO:0012505;cytoplasm#GO:0005737;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle membrane contact site#GO:0044232;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229 HUMAN|HGNC=29956|UniProtKB=Q86UW2 Q86UW2 SLC51B PTHR36129:SF1 ORGANIC SOLUTE TRANSPORTER SUBUNIT BETA-RELATED ORGANIC SOLUTE TRANSPORTER SUBUNIT BETA bile acid and bile salt transport#GO:0015721;organic acid transport#GO:0015849;transport#GO:0006810;carboxylic acid transport#GO:0046942;lipid localization#GO:0010876;organic hydroxy compound transport#GO:0015850;monocarboxylic acid transport#GO:0015718;localization#GO:0051179;establishment of localization#GO:0051234;secretion#GO:0046903;macromolecule localization#GO:0033036;lipid transport#GO:0006869 plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;basal part of cell#GO:0045178;basolateral plasma membrane#GO:0016323;membrane#GO:0016020;basal plasma membrane#GO:0009925;cell periphery#GO:0071944 transporter#PC00227 HUMAN|HGNC=21839|UniProtKB=A9QM74 A9QM74 KPNA7 PTHR23316:SF11 IMPORTIN ALPHA IMPORTIN SUBUNIT ALPHA-8 nucleocytoplasmic carrier activity#GO:0140142;molecular carrier activity#GO:0140104 protein localization to organelle#GO:0033365;nucleocytoplasmic transport#GO:0006913;localization#GO:0051179;NLS-bearing protein import into nucleus#GO:0006607;cellular localization#GO:0051641;nuclear transport#GO:0051169;protein transport#GO:0015031;protein import into nucleus#GO:0006606;macromolecule localization#GO:0033036;import into nucleus#GO:0051170;protein localization to nucleus#GO:0034504;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;intracellular transport#GO:0046907;transport#GO:0006810;intracellular protein transport#GO:0006886;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 transporter#PC00227 HUMAN|HGNC=10488|UniProtKB=P31949 P31949 S100A11 PTHR11639:SF60 S100 CALCIUM-BINDING PROTEIN PROTEIN S100-A11 calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;cation binding#GO:0043169;protein binding#GO:0005515;metal ion binding#GO:0046872 perinuclear region of cytoplasm#GO:0048471;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 calmodulin-related#PC00061;calcium-binding protein#PC00060 HUMAN|HGNC=28920|UniProtKB=Q5SW79 Q5SW79 CEP170 PTHR15715:SF17 CENTROSOMAL PROTEIN OF 170 KDA CENTROSOMAL PROTEIN OF 170 KDA protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 microtubule anchoring#GO:0034453;microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;microtubule anchoring at microtubule organizing center#GO:0072393;microtubule-based process#GO:0007017;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987 microtubule cytoskeleton#GO:0015630;organelle#GO:0043226;cellular anatomical structure#GO:0110165;centriole#GO:0005814;intracellular membraneless organelle#GO:0043232;microtubule organizing center#GO:0005815;centrosome#GO:0005813;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HUMAN|HGNC=18661|UniProtKB=Q8WXX0 Q8WXX0 DNAH7 PTHR10676:SF310 DYNEIN HEAVY CHAIN FAMILY PROTEIN DYNEIN AXONEMAL HEAVY CHAIN 7 protein binding#GO:0005515;microtubule motor activity#GO:0003777;binding#GO:0005488;polypeptide conformation or assembly isomerase activity#GO:0120544;ATP-dependent activity#GO:0140657;cytoskeletal motor activity#GO:0003774;isomerase activity#GO:0016853;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543 cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;cell projection assembly#GO:0030031;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cilium movement involved in cell motility#GO:0060294;protein-containing complex organization#GO:0043933;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;motile cilium assembly#GO:0044458;cell development#GO:0048468;cellular process involved in reproduction in multicellular organism#GO:0022412;cell differentiation#GO:0030154;cell projection organization#GO:0030030;gamete generation#GO:0007276;protein-containing complex assembly#GO:0065003;sperm motility#GO:0097722;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cilium organization#GO:0044782;sperm flagellum assembly#GO:0120316;cilium-dependent cell motility#GO:0060285;cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;inner dynein arm assembly#GO:0036159;spermatid differentiation#GO:0048515;plasma membrane bounded cell projection organization#GO:0120036;male gamete generation#GO:0048232;cellular developmental process#GO:0048869;spermatogenesis#GO:0007283;developmental process#GO:0032502;plasma membrane bounded cell projection assembly#GO:0120031;flagellated sperm motility#GO:0030317;reproductive process#GO:0022414;microtubule-based movement#GO:0007018;cell motility#GO:0048870;germ cell development#GO:0007281;developmental process involved in reproduction#GO:0003006;axoneme assembly#GO:0035082;multicellular organismal reproductive process#GO:0048609;anatomical structure development#GO:0048856;microtubule cytoskeleton organization#GO:0000226;sexual reproduction#GO:0019953;microtubule bundle formation#GO:0001578;spermatid development#GO:0007286;axonemal dynein complex assembly#GO:0070286;organelle assembly#GO:0070925 9+2 motile cilium#GO:0097729;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;cilium#GO:0005929;axoneme#GO:0005930;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;axonemal dynein complex#GO:0005858;dynein complex#GO:0030286;motile cilium#GO:0031514;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cytoskeleton#GO:0005856;inner dynein arm#GO:0036156;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;microtubule associated complex#GO:0005875;ciliary plasm#GO:0097014;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 Huntington disease#P00029>Dynein complex#P00774 HUMAN|HGNC=4504|UniProtKB=O75473 O75473 LGR5 PTHR24372:SF71 GLYCOPROTEIN HORMONE RECEPTOR LEUCINE-RICH REPEAT-CONTAINING G PROTEIN-COUPLED RECEPTOR 5 transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023 regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;regulation of Wnt signaling pathway#GO:0030111;signaling#GO:0023052;cellular response to hormone stimulus#GO:0032870;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;regulation of signaling#GO:0023051;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;hormone-mediated signaling pathway#GO:0009755;positive regulation of signaling#GO:0023056;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;response to hormone#GO:0009725;regulation of canonical Wnt signaling pathway#GO:0060828;positive regulation of Wnt signaling pathway#GO:0030177;response to chemical#GO:0042221;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;cell communication#GO:0007154;positive regulation of cellular process#GO:0048522;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;regulation of response to stimulus#GO:0048583;positive regulation of canonical Wnt signaling pathway#GO:0090263 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021 HUMAN|HGNC=12693|UniProtKB=P01282 P01282 VIP PTHR11213:SF5 GLUCAGON-FAMILY NEUROPEPTIDE VIP PEPTIDES signaling receptor binding#GO:0005102;hormone receptor binding#GO:0051427;binding#GO:0005488;protein binding#GO:0005515;hormone activity#GO:0005179;molecular function activator activity#GO:0140677;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;neuropeptide hormone activity#GO:0005184;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772 positive regulation of signaling#GO:0023056;secretion#GO:0046903;localization#GO:0051179;organic hydroxy compound transport#GO:0015850;secretion by cell#GO:0032940;regulation of protein localization#GO:0032880;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;export from cell#GO:0140352;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789;establishment of localization#GO:0051234;regulation of localization#GO:0032879;transport#GO:0006810;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;nitrogen compound transport#GO:0071705;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518 cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165;neuron projection#GO:0043005 neuropeptide#PC00162 HUMAN|HGNC=10068|UniProtKB=Q99942 Q99942 RNF5 PTHR12313:SF4 E3 UBIQUITIN-PROTEIN LIGASE RNF5-RELATED E3 UBIQUITIN-PROTEIN LIGASE RNF5 response to stress#GO:0006950;regulation of organelle assembly#GO:1902115;cellular process#GO:0009987;response to chemical#GO:0042221;biological regulation#GO:0065007;proteasomal protein catabolic process#GO:0010498;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;regulation of organelle organization#GO:0033043;catabolic process#GO:0009056;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of cellular component biogenesis#GO:0044087;regulation of autophagosome assembly#GO:2000785;response to endoplasmic reticulum stress#GO:0034976;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;ERAD pathway#GO:0036503 cellular anatomical structure#GO:0110165;membrane#GO:0016020 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=12007|UniProtKB=O43399 O43399 TPD52L2 PTHR19307:SF13 TUMOR PROTEIN D52 TUMOR PROTEIN D54 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=9343|UniProtKB=Q92733 Q92733 PRCC PTHR13621:SF2 PROLINE-RICH PROTEIN PRCC PROLINE-RICH PROTEIN PRCC intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=3443|UniProtKB=O14944 O14944 EREG PTHR10740:SF11 TRANSFORMING GROWTH FACTOR ALPHA PROEPIREGULIN protein binding#GO:0005515;molecular function activator activity#GO:0140677;binding#GO:0005488;signaling receptor binding#GO:0005102;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;signaling receptor regulator activity#GO:0030545;growth factor activity#GO:0008083;receptor ligand activity#GO:0048018;growth factor receptor binding#GO:0070851 epidermal growth factor receptor signaling pathway#GO:0007173;regulation of nuclear division#GO:0051783;positive regulation of cell cycle#GO:0045787;biological regulation#GO:0065007;regulation of cell cycle process#GO:0010564;ERBB signaling pathway#GO:0038127;cellular process#GO:0009987;regulation of mitotic cell cycle#GO:0007346;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;regulation of mitotic nuclear division#GO:0007088;cell surface receptor signaling pathway#GO:0007166;positive regulation of mitotic nuclear division#GO:0045840;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;signaling#GO:0023052;regulation of cell cycle#GO:0051726;positive regulation of cell population proliferation#GO:0008284;regulation of organelle organization#GO:0033043;cellular response to stimulus#GO:0051716;positive regulation of cell cycle process#GO:0090068;regulation of biological process#GO:0050789;positive regulation of organelle organization#GO:0010638;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of cell population proliferation#GO:0042127;cell communication#GO:0007154;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of cellular component organization#GO:0051130 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 growth factor#PC00112 EGF receptor signaling pathway#P00018>EGF#P00549 HUMAN|HGNC=1370|UniProtKB=O75493 O75493 CA11 PTHR18952:SF93 CARBONIC ANHYDRASE CARBONIC ANHYDRASE-RELATED PROTEIN 11 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;cell periphery#GO:0071944;basal plasma membrane#GO:0009925;membrane#GO:0016020;basal part of cell#GO:0045178;basolateral plasma membrane#GO:0016323 dehydratase#PC00091;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=51714|UniProtKB=A0A096LP55 A0A096LP55 UQCRHL PTHR15336:SF6 UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 7.8 KDA PROTEIN CYTOCHROME B-C1 COMPLEX SUBUNIT 6-LIKE, MITOCHONDRIAL aerobic respiration#GO:0009060;ATP synthesis coupled electron transport#GO:0042773;oxidative phosphorylation#GO:0006119;cellular respiration#GO:0045333;energy derivation by oxidation of organic compounds#GO:0015980;generation of precursor metabolites and energy#GO:0006091;metabolic process#GO:0008152;aerobic electron transport chain#GO:0019646;mitochondrial electron transport, ubiquinol to cytochrome c#GO:0006122;mitochondrial ATP synthesis coupled electron transport#GO:0042775;cellular process#GO:0009987;respiratory electron transport chain#GO:0022904;electron transport chain#GO:0022900 catalytic complex#GO:1902494;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;respiratory chain complex III#GO:0045275;oxidoreductase complex#GO:1990204;membrane#GO:0016020;membrane protein complex#GO:0098796;cytochrome complex#GO:0070069;respiratory chain complex#GO:0098803;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;reductase#PC00198 HUMAN|HGNC=23433|UniProtKB=Q8IXQ3 Q8IXQ3 C9orf40 PTHR16003:SF3 C9ORF40 ISOFORM 1 CHROMOSOME 1 C9ORF40 HOMOLOG HUMAN|HGNC=29540|UniProtKB=Q9ULX3 Q9ULX3 NOB1 PTHR12814:SF2 RNA-BINDING PROTEIN NOB1 RNA-BINDING PROTEIN NOB1 RNA endonuclease activity#GO:0004521;catalytic activity, acting on RNA#GO:0140098;nuclease activity#GO:0004518;RNA nuclease activity#GO:0004540;endonuclease activity#GO:0004519;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640 nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;ribosomal small subunit biogenesis#GO:0042274;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;maturation of SSU-rRNA#GO:0030490;gene expression#GO:0010467 protein-containing complex#GO:0032991;ribonucleoprotein complex#GO:1990904;preribosome#GO:0030684 HUMAN|HGNC=28986|UniProtKB=Q92610 Q92610 ZNF592 PTHR47222:SF1 ZINC FINGER PROTEIN 532-RELATED ZINC FINGER PROTEIN 592 HUMAN|HGNC=24161|UniProtKB=Q9BTY7 Q9BTY7 HGH1 PTHR13387:SF9 PROTEIN HGH1 HOMOLOG CO-CHAPERONE PROTEIN HGH1 HOMOLOG HUMAN|HGNC=16773|UniProtKB=Q9BYP9 Q9BYP9 KRTAP9-9 PTHR23262:SF133 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 9-6-RELATED structural protein#PC00211 HUMAN|HGNC=1914|UniProtKB=O95199 O95199 RCBTB2 PTHR22870:SF220 REGULATOR OF CHROMOSOME CONDENSATION RCC1 AND BTB DOMAIN-CONTAINING PROTEIN 2 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=17481|UniProtKB=O43164 O43164 PJA2 PTHR15710:SF5 E3 UBIQUITIN-PROTEIN LIGASE PRAJA E3 UBIQUITIN-PROTEIN LIGASE PRAJA-2 positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;positive regulation of response to stimulus#GO:0048584;regulation of cell communication#GO:0010646;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of intracellular signal transduction#GO:1902531;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of signaling#GO:0023056 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=16638|UniProtKB=Q8IYB3 Q8IYB3 SRRM1 PTHR23148:SF0 SERINE/ARGININE REGULATED NUCLEAR MATRIX PROTEIN SERINE_ARGININE REPETITIVE MATRIX PROTEIN 1 binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 biological regulation#GO:0065007;regulation of RNA splicing#GO:0043484;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of mRNA processing#GO:0050684;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of mRNA metabolic process#GO:1903311 intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226 RNA processing factor#PC00147 HUMAN|HGNC=22923|UniProtKB=Q96IJ6 Q96IJ6 GMPPA PTHR22572:SF104 SUGAR-1-PHOSPHATE GUANYL TRANSFERASE MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE REGULATORY SUBUNIT ALPHA transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;nucleotidyltransferase activity#GO:0016779 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 transferase#PC00220 Mannose metabolism#P02752>Mannose 1-P guanylyl transferase#P03018 HUMAN|HGNC=21088|UniProtKB=Q86SK9 Q86SK9 SCD5 PTHR11351:SF100 ACYL-COA DESATURASE STEAROYL-COA DESATURASE 5 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;iron ion binding#GO:0005506;transition metal ion binding#GO:0046914;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;cation binding#GO:0043169;metal ion binding#GO:0046872 monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;carboxylic acid biosynthetic process#GO:0046394;small molecule metabolic process#GO:0044281;oxoacid metabolic process#GO:0043436;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058;fatty acid biosynthetic process#GO:0006633;unsaturated fatty acid biosynthetic process#GO:0006636;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;unsaturated fatty acid metabolic process#GO:0033559;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;monocarboxylic acid biosynthetic process#GO:0072330 endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane#GO:0016020;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=4588|UniProtKB=O15399 O15399 GRIN2D PTHR18966:SF385 IONOTROPIC GLUTAMATE RECEPTOR GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2D transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;glutamate receptor activity#GO:0008066;ligand-gated channel activity#GO:0022834;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;dicarboxylic acid transmembrane transporter activity#GO:0005310;ligand-gated monoatomic ion channel activity#GO:0015276;carboxylic acid transmembrane transporter activity#GO:0046943;channel activity#GO:0015267;molecular transducer activity#GO:0060089;transporter activity#GO:0005215;neurotransmitter receptor activity#GO:0030594;amino acid transmembrane transporter activity#GO:0015171;signaling receptor activity#GO:0038023;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;gated channel activity#GO:0022836;transmembrane signaling receptor activity#GO:0004888;voltage-gated monoatomic ion channel activity#GO:0005244;voltage-gated channel activity#GO:0022832 positive regulation of cellular process#GO:0048522;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regulation of synaptic plasticity#GO:0048167;system process#GO:0003008;regulation of postsynaptic membrane potential#GO:0060078;cellular response to stimulus#GO:0051716;chemical synaptic transmission#GO:0007268;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;chemical synaptic transmission, postsynaptic#GO:0099565;anterograde trans-synaptic signaling#GO:0098916;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;synaptic signaling#GO:0099536;synaptic transmission, glutamatergic#GO:0035249;regulation of trans-synaptic signaling#GO:0099177;cell surface receptor signaling pathway#GO:0007166;regulation of membrane potential#GO:0042391;regulation of biological process#GO:0050789;signaling#GO:0023052;response to stimulus#GO:0050896;nervous system process#GO:0050877;regulation of signaling#GO:0023051;positive regulation of synaptic transmission#GO:0050806;regulation of biological quality#GO:0065008;positive regulation of signaling#GO:0023056 transmembrane transporter complex#GO:1902495;postsynaptic density membrane#GO:0098839;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;postsynaptic density#GO:0014069;organelle#GO:0043226;asymmetric synapse#GO:0032279;cellular anatomical structure#GO:0110165;synapse#GO:0045202;membrane protein complex#GO:0098796;postsynapse#GO:0098794;plasma membrane protein complex#GO:0098797;cell junction#GO:0030054;transporter complex#GO:1990351;signaling receptor complex#GO:0043235;synaptic membrane#GO:0097060;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;neuron to neuron synapse#GO:0098984;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 Metabotropic glutamate receptor group I pathway#P00041>NMDA#P01060;Ionotropic glutamate receptor pathway#P00037>NMDA#P01024;Metabotropic glutamate receptor group III pathway#P00039>NMDA#P01039;Ionotropic glutamate receptor pathway#P00037>NR2D#P01005;Huntington disease#P00029>NMDA receptor#P00778;Ionotropic glutamate receptor pathway#P00037>NR2C#P01006;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>NMDA#P01071 HUMAN|HGNC=10044|UniProtKB=P07998 P07998 RNASE1 PTHR11437:SF24 RIBONUCLEASE RIBONUCLEASE PANCREATIC catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on RNA#GO:0140098;nuclease activity#GO:0004518;RNA nuclease activity#GO:0004540 response to stress#GO:0006950;response to biotic stimulus#GO:0009607;defense response to Gram-positive bacterium#GO:0050830;response to stimulus#GO:0050896;response to other organism#GO:0051707;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to bacterium#GO:0009617;defense response to bacterium#GO:0042742;defense response#GO:0006952;response to external stimulus#GO:0009605 RNA metabolism protein#PC00031;endoribonuclease#PC00094 HUMAN|HGNC=16969|UniProtKB=Q92598 Q92598 HSPH1 PTHR45639:SF2 HSC70CB, ISOFORM G-RELATED HEAT SHOCK PROTEIN 105 KDA molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589 metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;protein folding#GO:0006457;protein maturation#GO:0051604;gene expression#GO:0010467 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 Hsp70 family chaperone#PC00027;chaperone#PC00072 HUMAN|HGNC=10707|UniProtKB=Q8WVN6 Q8WVN6 SECTM1 PTHR15123:SF5 SECRETED AND TRANSMEMBRANE PROTEIN 1 SECRETED AND TRANSMEMBRANE PROTEIN 1 signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546 positive regulation of immune system process#GO:0002684;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604;regulation of multicellular organismal process#GO:0051239;regulation of biological process#GO:0050789;positive regulation of multicellular organismal process#GO:0051240;positive regulation of adaptive immune response#GO:0002821;regulation of cytokine production involved in immune response#GO:0002718;regulation of lymphocyte mediated immunity#GO:0002706;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of cytokine production#GO:0001817;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of cellular process#GO:0048522;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;positive regulation of immune effector process#GO:0002699;positive regulation of leukocyte mediated immunity#GO:0002705;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;regulation of biosynthetic process#GO:0009889;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;regulation of leukocyte mediated immunity#GO:0002703;regulation of macromolecule metabolic process#GO:0060255;positive regulation of cytokine production#GO:0001819;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of immune response#GO:0050776;positive regulation of lymphocyte mediated immunity#GO:0002708;positive regulation of biosynthetic process#GO:0009891;regulation of immune effector process#GO:0002697 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HUMAN|HGNC=24902|UniProtKB=Q8WUY9 Q8WUY9 DEPDC1B PTHR16206:SF11 DEP DOMAIN-CONTAINING DEP DOMAIN-CONTAINING PROTEIN 1B positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111;positive regulation of Wnt signaling pathway#GO:0030177;positive regulation of response to stimulus#GO:0048584;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of biological process#GO:0050789;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of signal transduction#GO:0009967 scaffold/adaptor protein#PC00226 HUMAN|HGNC=10621|UniProtKB=O00626 O00626 CCL22 PTHR12015:SF102 SMALL INDUCIBLE CYTOKINE A C-C MOTIF CHEMOKINE 22 molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;chemokine activity#GO:0008009;G protein-coupled receptor binding#GO:0001664;chemokine receptor binding#GO:0042379;protein binding#GO:0005515;molecular function activator activity#GO:0140677;cytokine activity#GO:0005125;binding#GO:0005488;signaling receptor binding#GO:0005102;cytokine receptor binding#GO:0005126 cell chemotaxis#GO:0060326;chemokine-mediated signaling pathway#GO:0070098;regulation of cell motility#GO:2000145;cell communication#GO:0007154;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;chemotaxis#GO:0006935;inflammatory response#GO:0006954;cytokine-mediated signaling pathway#GO:0019221;response to external biotic stimulus#GO:0043207;locomotion#GO:0040011;cellular response to chemokine#GO:1990869;cell motility#GO:0048870;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;myeloid leukocyte migration#GO:0097529;response to external stimulus#GO:0009605;positive regulation of locomotion#GO:0040017;defense response#GO:0006952;leukocyte chemotaxis#GO:0030595;regulation of cell migration#GO:0030334;leukocyte migration#GO:0050900;biological regulation#GO:0065007;response to other organism#GO:0051707;regulation of locomotion#GO:0040012;cell migration#GO:0016477;positive regulation of cellular process#GO:0048522;immune response#GO:0006955;positive regulation of cell migration#GO:0030335;response to peptide#GO:1901652;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;immune system process#GO:0002376;biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052;response to stimulus#GO:0050896;granulocyte chemotaxis#GO:0071621;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;positive regulation of cell motility#GO:2000147;cell surface receptor signaling pathway#GO:0007166;humoral immune response#GO:0006959;antimicrobial humoral response#GO:0019730;response to cytokine#GO:0034097;taxis#GO:0042330;response to chemical#GO:0042221;defense response to other organism#GO:0098542;granulocyte migration#GO:0097530;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;defense response to symbiont#GO:0140546;cellular process#GO:0009987;response to chemokine#GO:1990868;response to biotic stimulus#GO:0009607;response to stress#GO:0006950 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 cytokine#PC00083 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CHK#P00856 HUMAN|HGNC=12264|UniProtKB=A0JD37 A0JD37 TRDV3 PTHR23267:SF189 IMMUNOGLOBULIN LIGHT CHAIN T CELL RECEPTOR DELTA VARIABLE 3 response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 protein-containing complex#GO:0032991 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=2861|UniProtKB=P00374 P00374 DHFR PTHR48069:SF6 DIHYDROFOLATE REDUCTASE DIHYDROFOLATE REDUCTASE catalytic activity#GO:0003824;purine nucleotide binding#GO:0017076;nucleotide binding#GO:0000166;heterocyclic compound binding#GO:1901363;oxidoreductase activity#GO:0016491;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;small molecule binding#GO:0036094 tetrahydrofolate biosynthetic process#GO:0046654;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;tetrahydrofolate metabolic process#GO:0046653;cellular process#GO:0009987;carboxylic acid metabolic process#GO:0019752;modified amino acid metabolic process#GO:0006575;biosynthetic process#GO:0009058;small molecule metabolic process#GO:0044281;folic acid-containing compound metabolic process#GO:0006760;pteridine-containing compound metabolic process#GO:0042558 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 oxidoreductase#PC00176;reductase#PC00198 Formyltetrahydrofolate biosynthesis#P02743>Dihydrofolate reductase#P02957;Tetrahydrofolate biosynthesis#P02742>Dihydrofolate synthase#P02943;Tetrahydrofolate biosynthesis#P02742>Dihydrofolate reductase#P02948 HUMAN|HGNC=20657|UniProtKB=O60635 O60635 TSPAN1 PTHR19282:SF216 TETRASPANIN TETRASPANIN-1 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HUMAN|Ensembl=ENSG00000250138.5|UniProtKB=A0ABB0MVE9 A0ABB0MVE9 PTHR15566:SF4 POM121-LIKE POM121-LIKE PROTEIN 1-RELATED HUMAN|HGNC=26172|UniProtKB=Q9H6K5 Q9H6K5 PRR36 PTHR22427:SF8 GH15728P PROLINE-RICH PROTEIN 36 HUMAN|HGNC=1491|UniProtKB=P47756 P47756 CAPZB PTHR10619:SF1 F-ACTIN-CAPPING PROTEIN SUBUNIT BETA F-ACTIN-CAPPING PROTEIN SUBUNIT BETA binding#GO:0005488;actin binding#GO:0003779;actin filament binding#GO:0051015;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877 cellular process#GO:0009987;organelle organization#GO:0006996;regulation of protein-containing complex disassembly#GO:0043244;cytoskeleton organization#GO:0007010;regulation of actin cytoskeleton organization#GO:0032956;regulation of anatomical structure size#GO:0090066;cellular component organization or biogenesis#GO:0071840;regulation of cellular component size#GO:0032535;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;negative regulation of biological process#GO:0048519;regulation of protein-containing complex assembly#GO:0043254;cellular component organization#GO:0016043;negative regulation of actin filament polymerization#GO:0030837;regulation of cellular component biogenesis#GO:0044087;regulation of cellular component organization#GO:0051128;regulation of actin filament length#GO:0030832;negative regulation of actin filament depolymerization#GO:0030835;regulation of biological quality#GO:0065008;regulation of actin filament organization#GO:0110053;biological regulation#GO:0065007;regulation of actin polymerization or depolymerization#GO:0008064;negative regulation of protein depolymerization#GO:1901880;regulation of actin filament polymerization#GO:0030833;regulation of actin filament-based process#GO:0032970;negative regulation of cellular process#GO:0048523;regulation of protein depolymerization#GO:1901879;regulation of supramolecular fiber organization#GO:1902903;negative regulation of cellular component organization#GO:0051129;negative regulation of organelle organization#GO:0010639;regulation of actin filament depolymerization#GO:0030834;regulation of cytoskeleton organization#GO:0051493;negative regulation of supramolecular fiber organization#GO:1902904;regulation of protein polymerization#GO:0032271;regulation of cellular process#GO:0050794;actin cytoskeleton organization#GO:0030036;actin filament capping#GO:0051693;negative regulation of protein polymerization#GO:0032272;actin filament-based process#GO:0030029;negative regulation of protein-containing complex assembly#GO:0031333;negative regulation of cytoskeleton organization#GO:0051494;negative regulation of protein-containing complex disassembly#GO:0043242 cell periphery#GO:0071944;cell cortex#GO:0005938;cortical cytoskeleton#GO:0030863;actin cytoskeleton#GO:0015629;cortical actin cytoskeleton#GO:0030864;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 non-motor actin binding protein#PC00165 HUMAN|HGNC=24871|UniProtKB=Q8N6N3 Q8N6N3 C1orf52 PTHR31833:SF2 UPF0690 PROTEIN C1ORF52 UPF0690 PROTEIN C1ORF52 HUMAN|HGNC=1582|UniProtKB=P24385 P24385 CCND1 PTHR10177:SF67 CYCLINS G1_S-SPECIFIC CYCLIN-D1 cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538;enzyme regulator activity#GO:0030234;protein kinase regulator activity#GO:0019887;cyclin-dependent protein kinase regulator activity#GO:0019914;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772 G1/S transition of mitotic cell cycle#GO:0000082;positive regulation of cell cycle G1/S phase transition#GO:1902808;positive regulation of mitotic cell cycle#GO:0045931;mitotic cell cycle process#GO:1903047;cellular process#GO:0009987;regulation of mitotic cell cycle#GO:0007346;cell cycle G1/S phase transition#GO:0044843;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of cell cycle#GO:0045787;regulation of cell cycle process#GO:0010564;biological regulation#GO:0065007;regulation of G1/S transition of mitotic cell cycle#GO:2000045;mitotic cell cycle phase transition#GO:0044772;regulation of mitotic cell cycle phase transition#GO:1901990;cell cycle process#GO:0022402;positive regulation of cell cycle process#GO:0090068;regulation of biological process#GO:0050789;regulation of cell cycle phase transition#GO:1901987;cell cycle#GO:0007049;regulation of cell cycle#GO:0051726;regulation of cell cycle G1/S phase transition#GO:1902806;regulation of cellular process#GO:0050794;cell cycle phase transition#GO:0044770;mitotic cell cycle#GO:0000278 cyclin-dependent protein kinase holoenzyme complex#GO:0000307;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;nucleus#GO:0005634;microtubule cytoskeleton#GO:0015630;protein kinase complex#GO:1902911;membraneless organelle#GO:0043228;transferase complex#GO:1990234;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695 kinase activator#PC00138 CCKR signaling map#P06959>CCND1#G07280;CCKR signaling map#P06959>CCND1#G06986;Cell cycle#P00013>Cyclin D#P00484;Wnt signaling pathway#P00057>Wnt Target Genes#G01558;PI3 kinase pathway#P00048>Cyclin d#G01546 HUMAN|HGNC=51826|UniProtKB=A8MUP6 A8MUP6 GSG1L2 PTHR10671:SF40 EPITHELIAL MEMBRANE PROTEIN-RELATED GERM CELL-SPECIFIC GENE 1-LIKE PROTEIN 2 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 cytoskeletal protein#PC00085 HUMAN|HGNC=25495|UniProtKB=Q9NW82 Q9NW82 WDR70 PTHR16017:SF0 GASTRULATION DEFECTIVE PROTEIN 1-RELATED WD REPEAT-CONTAINING PROTEIN 70 intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;site of DNA damage#GO:0090734;membrane-bounded organelle#GO:0043227;chromosome#GO:0005694;site of double-strand break#GO:0035861;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232 HUMAN|HGNC=4454|UniProtKB=Q9Y625 Q9Y625 GPC6 PTHR10822:SF31 GLYPICAN GLYPICAN-6 regulation of biological quality#GO:0065008;regulation of protein localization#GO:0032880;regulation of localization#GO:0032879;cellular process#GO:0009987;regulation of biological process#GO:0050789;regulation of protein localization to membrane#GO:1905475;cell migration#GO:0016477;regulation of cellular process#GO:0050794;cell motility#GO:0048870;biological regulation#GO:0065007 extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cell junction#GO:0030054;cell surface#GO:0009986;synapse#GO:0045202;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=15975|UniProtKB=O75995 O75995 SASH3 PTHR12301:SF5 SAM-DOMAIN, SH3 AND NUCLEAR LOCALIZATION SIGNALS PROTEIN RELATED SAM AND SH3 DOMAIN-CONTAINING PROTEIN 3 positive regulation of response to stimulus#GO:0048584;regulation of lymphocyte proliferation#GO:0050670;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of immune effector process#GO:0002699;positive regulation of cell activation#GO:0050867;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;regulation of biosynthetic process#GO:0009889;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;positive regulation of leukocyte proliferation#GO:0070665;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;positive regulation of B cell proliferation#GO:0030890;regulation of cell communication#GO:0010646;regulation of cell population proliferation#GO:0042127;positive regulation of lymphocyte activation#GO:0051251;positive regulation of biosynthetic process#GO:0009891;regulation of immune effector process#GO:0002697;regulation of immune response#GO:0050776;positive regulation of lymphocyte proliferation#GO:0050671;positive regulation of macromolecule metabolic process#GO:0010604;regulation of multicellular organismal process#GO:0051239;positive regulation of immune system process#GO:0002684;regulation of B cell activation#GO:0050864;regulation of mononuclear cell proliferation#GO:0032944;positive regulation of biological process#GO:0048518;regulation of leukocyte proliferation#GO:0070663;positive regulation of mononuclear cell proliferation#GO:0032946;regulation of B cell proliferation#GO:0030888;positive regulation of leukocyte activation#GO:0002696;positive regulation of adaptive immune response#GO:0002821;regulation of lymphocyte activation#GO:0051249;regulation of leukocyte activation#GO:0002694;positive regulation of cell population proliferation#GO:0008284;regulation of biological process#GO:0050789;positive regulation of multicellular organismal process#GO:0051240;regulation of cell activation#GO:0050865;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=19583|UniProtKB=O95013 O95013 OR4F21 PTHR48002:SF1 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 4F21-RELATED molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=21524|UniProtKB=Q9Y394 Q9Y394 DHRS7 PTHR44269:SF1 DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7-RELATED DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 7 alcohol dehydrogenase (NADP+) activity#GO:0008106;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455 nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 dehydrogenase#PC00092 HUMAN|HGNC=3498|UniProtKB=Q03112 Q03112 MECOM PTHR24393:SF69 ZINC FINGER PROTEIN HISTONE-LYSINE N-METHYLTRANSFERASE MECOM transcription regulatory region nucleic acid binding#GO:0001067;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;DNA-binding transcription activator activity#GO:0001216;sequence-specific DNA binding#GO:0043565;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HUMAN|HGNC=34527|UniProtKB=A6H8M9 A6H8M9 CDHR4 PTHR24028:SF123 CADHERIN-87A CADHERIN-RELATED FAMILY MEMBER 4 cellular process#GO:0009987;cell adhesion#GO:0007155 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 cadherin#PC00057;cell adhesion molecule#PC00069 HUMAN|HGNC=19304|UniProtKB=O95104 O95104 SCAF4 PTHR23140:SF3 RNA PROCESSING PROTEIN LD23810P SR-RELATED AND CTD-ASSOCIATED FACTOR 4 RNA polymerase binding#GO:0070063;RNA polymerase core enzyme binding#GO:0043175;enzyme binding#GO:0019899;nucleic acid binding#GO:0003676;binding#GO:0005488;protein binding#GO:0005515;RNA binding#GO:0003723;RNA polymerase II complex binding#GO:0000993 negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of protein-containing complex disassembly#GO:0043244;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of protein-containing complex disassembly#GO:0043242;regulation of DNA-templated transcription#GO:0006355;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of cellular component organization#GO:0051129;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular component organization#GO:0051128;negative regulation of metabolic process#GO:0009892 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 RNA processing factor#PC00147 HUMAN|HGNC=18241|UniProtKB=Q96LA8 Q96LA8 PRMT6 PTHR11006:SF73 PROTEIN ARGININE N-METHYLTRANSFERASE PROTEIN ARGININE N-METHYLTRANSFERASE 6 catalytic activity, acting on a protein#GO:0140096;protein methyltransferase activity#GO:0008276;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring one-carbon groups#GO:0016741;histone modifying activity#GO:0140993;histone methyltransferase activity#GO:0042054;N-methyltransferase activity#GO:0008170;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757 chromatin organization#GO:0006325;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;chromatin remodeling#GO:0006338;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355 protein modifying enzyme#PC00260 HUMAN|HGNC=18442|UniProtKB=Q0VAF6 Q0VAF6 SYCN PTHR17503:SF0 SYNCOLLIN SYNCOLLIN HUMAN|HGNC=8054|UniProtKB=P0C024 P0C024 NUDT7 PTHR12992:SF48 NUDIX HYDROLASE PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7 hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787 nucleoside phosphate catabolic process#GO:1901292;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521;organophosphate catabolic process#GO:0046434;nucleobase-containing compound metabolic process#GO:0006139;sulfur compound metabolic process#GO:0006790;nucleobase-containing compound catabolic process#GO:0034655;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;sulfur compound catabolic process#GO:0044273;purine-containing compound catabolic process#GO:0072523;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;microbody#GO:0042579;peroxisome#GO:0005777 hydrolase#PC00121;phosphatase#PC00181 HUMAN|HGNC=2150|UniProtKB=Q16281 Q16281 CNGA3 PTHR45638:SF6 CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A CYCLIC NUCLEOTIDE-GATED CHANNEL ALPHA-3 channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276;ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;nucleotide binding#GO:0000166;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;guanyl ribonucleotide binding#GO:0032561;monoatomic cation transmembrane transporter activity#GO:0008324;gated channel activity#GO:0022836;guanyl nucleotide binding#GO:0019001;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;heterocyclic compound binding#GO:1901363;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;purine ribonucleotide binding#GO:0032555;transporter activity#GO:0005215;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076 transmembrane transport#GO:0055085;anatomical structure development#GO:0048856;monoatomic cation transport#GO:0006812;localization#GO:0051179;eye development#GO:0001654;monoatomic ion transport#GO:0006811;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;camera-type eye development#GO:0043010;nervous system process#GO:0050877;sensory perception#GO:0007600;visual system development#GO:0150063;establishment of localization#GO:0051234;animal organ development#GO:0048513;multicellular organism development#GO:0007275;system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606;sensory organ development#GO:0007423;transport#GO:0006810;developmental process#GO:0032502;multicellular organismal process#GO:0032501;monoatomic ion transmembrane transport#GO:0034220;retina development in camera-type eye#GO:0060041;monoatomic cation transmembrane transport#GO:0098655;sensory system development#GO:0048880;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;cell periphery#GO:0071944;membrane protein complex#GO:0098796;membrane#GO:0016020;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;cation channel complex#GO:0034703 ion channel#PC00133;ligand-gated ion channel#PC00141 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>cGMP-gated ion channel#P00752 HUMAN|HGNC=15913|UniProtKB=Q9UKK6 Q9UKK6 NXT1 PTHR12612:SF4 NUCLEAR TRANSPORT FACTOR 2 NTF2-RELATED EXPORT PROTEIN 1 metabolic process#GO:0008152;RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907;transport#GO:0006810;poly(A)+ mRNA export from nucleus#GO:0016973;macromolecule metabolic process#GO:0043170;establishment of localization#GO:0051234;macromolecule localization#GO:0033036;nitrogen compound transport#GO:0071705;establishment of localization in cell#GO:0051649;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleocytoplasmic transport#GO:0006913;localization#GO:0051179;cellular localization#GO:0051641;nucleic acid transport#GO:0050657;mRNA export from nucleus#GO:0006406;nuclear transport#GO:0051169;nuclear export#GO:0051168;nucleobase-containing compound transport#GO:0015931;RNA transport#GO:0050658;RNA localization#GO:0006403;mRNA transport#GO:0051028;establishment of RNA localization#GO:0051236 nucleus#GO:0005634;organelle envelope#GO:0031967;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear pore#GO:0005643;nuclear protein-containing complex#GO:0140513 HUMAN|HGNC=9802|UniProtKB=P15153 P15153 RAC2 PTHR24072:SF169 RHO FAMILY GTPASE RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2 ion binding#GO:0043167;GTPase activity#GO:0003924;anion binding#GO:0043168;small molecule binding#GO:0036094;hydrolase activity#GO:0016787;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;kinase binding#GO:0019900;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;protein kinase binding#GO:0019901;guanyl nucleotide binding#GO:0019001;enzyme binding#GO:0019899;protein binding#GO:0005515;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363 regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;regulation of plasma membrane bounded cell projection assembly#GO:0120032;regulation of cellular component biogenesis#GO:0044087;signaling#GO:0023052;cellular component organization#GO:0016043;regulation of organelle organization#GO:0033043;regulation of cell shape#GO:0008360;regulation of biological process#GO:0050789;regulation of biological quality#GO:0065008;establishment or maintenance of cell polarity#GO:0007163;positive regulation of cellular component organization#GO:0051130;positive regulation of cellular component biogenesis#GO:0044089;response to chemical#GO:0042221;taxis#GO:0042330;regulation of actin cytoskeleton organization#GO:0032956;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;regulation of anatomical structure morphogenesis#GO:0022603;cellular component organization or biogenesis#GO:0071840;regulation of immune system process#GO:0002682;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;regulation of cytoskeleton organization#GO:0051493;regulation of leukocyte migration#GO:0002685;locomotion#GO:0040011;regulation of developmental process#GO:0050793;cellular response to stimulus#GO:0051716;regulation of cell motility#GO:2000145;cell communication#GO:0007154;regulation of cell projection assembly#GO:0060491;supramolecular fiber organization#GO:0097435;cortical cytoskeleton organization#GO:0030865;actin filament-based process#GO:0030029;positive regulation of cell projection organization#GO:0031346;chemotaxis#GO:0006935;regulation of locomotion#GO:0040012;biological regulation#GO:0065007;positive regulation of cellular process#GO:0048522;regulation of plasma membrane bounded cell projection organization#GO:0120035;actin filament organization#GO:0007015;response to external stimulus#GO:0009605;regulation of actin filament-based process#GO:0032970;regulation of cell projection organization#GO:0031344;regulation of cell migration#GO:0030334 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;intracellular membrane-bounded organelle#GO:0043231;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737 G-protein#PC00020;small GTPase#PC00208 Axon guidance mediated by Slit/Robo#P00008>Rac#P00354;p38 MAPK pathway#P05918>Rac#P06021;B cell activation#P00010>Rac#P00385;VEGF signaling pathway#P00056>Rac#P01421;Cytoskeletal regulation by Rho GTPase#P00016>Rac#P00523;Axon guidance mediated by semaphorins#P00007>Rac#P00340;Axon guidance mediated by netrin#P00009>Rac#P00366;FGF signaling pathway#P00021>Rac#P00645;Huntington disease#P00029>Rac#P00775;Integrin signalling pathway#P00034>Rac#P00927;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Cdc42#P00834;T cell activation#P00053>rac#P01324;Ras Pathway#P04393>Rac#P04559;EGF receptor signaling pathway#P00018>Rac#P00564 HUMAN|HGNC=9399|UniProtKB=Q05655 Q05655 PRKCD PTHR24356:SF365 SERINE/THREONINE-PROTEIN KINASE PROTEIN KINASE C DELTA TYPE protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 non-receptor serine/threonine protein kinase#PC00167 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>PKC#P00745;Alzheimer disease-amyloid secretase pathway#P00003>PKC#P00109;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>PKC#P01074;Gonadotropin-releasing hormone receptor pathway#P06664>PKCs#P06733;5HT2 type receptor mediated signaling pathway#P04374>PKC#P04420;Gonadotropin-releasing hormone receptor pathway#P06664>PKCs(3)#P06850;Gonadotropin-releasing hormone receptor pathway#P06664>nPKCs#P06852;Apoptosis signaling pathway#P00006>PKCs#P00318;Alpha adrenergic receptor signaling pathway#P00002>PKC#P00075;B cell activation#P00010>PKC#P00373;Thyrotropin-releasing hormone receptor signaling pathway#P04394>PKC#P04583;FGF signaling pathway#P00021>PKC#P00648;Oxytocin receptor mediated signaling pathway#P04391>PKC#P04533;Wnt signaling pathway#P00057>Protein Kinase C#P01458;Endothelin signaling pathway#P00019>PKC#P00568;CCKR signaling map#P06959>PKCdelta#P07134;EGF receptor signaling pathway#P00018>PKC#P00565;Histamine H1 receptor mediated signaling pathway#P04385>PKC#P04487;VEGF signaling pathway#P00056>PKC#P01425;Angiogenesis#P00005>PKC#P00219 HUMAN|HGNC=17840|UniProtKB=Q9BSY4 Q9BSY4 CHCHD5 PTHR47106:SF1 COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 5 COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 5 metabolic process#GO:0008152;cellular process#GO:0009987;generation of precursor metabolites and energy#GO:0006091;energy derivation by oxidation of organic compounds#GO:0015980;cellular respiration#GO:0045333 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;mitochondrial envelope#GO:0005740;organelle envelope#GO:0031967;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;mitochondrial intermembrane space#GO:0005758;intracellular organelle lumen#GO:0070013 HUMAN|HGNC=7863|UniProtKB=Q13423 Q13423 NNT PTHR10160:SF22 NAD(P) TRANSHYDROGENASE NAD(P) TRANSHYDROGENASE, MITOCHONDRIAL nucleotide binding#GO:0000166;heterocyclic compound binding#GO:1901363;purine nucleotide binding#GO:0017076;small molecule binding#GO:0036094;binding#GO:0005488;nucleoside phosphate binding#GO:1901265 small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;nucleotide metabolic process#GO:0009117;NADPH regeneration#GO:0006740;pyridine-containing compound metabolic process#GO:0072524;nucleobase-containing compound metabolic process#GO:0006139;NADP+ metabolic process#GO:0006739;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;nicotinamide nucleotide metabolic process#GO:0046496;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091 metabolite interconversion enzyme#PC00262;dehydrogenase#PC00092 HUMAN|HGNC=8517|UniProtKB=Q9NRC9 Q9NRC9 OTOR PTHR47146:SF1 OTORAPLIN OTORAPLIN anatomical structure morphogenesis#GO:0009653;cellular process#GO:0009987;skeletal system morphogenesis#GO:0048705;multicellular organismal process#GO:0032501;tissue development#GO:0009888;animal organ morphogenesis#GO:0009887;developmental process#GO:0032502;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;connective tissue development#GO:0061448;cartilage development#GO:0051216;multicellular organism development#GO:0007275;skeletal system development#GO:0001501;anatomical structure development#GO:0048856;animal organ development#GO:0048513 HUMAN|HGNC=18922|UniProtKB=Q8IUC1 Q8IUC1 KRTAP11-1 PTHR23260:SF9 KERATIN ASSOCIATED PROTEIN 3-3-RELATED KERATIN-ASSOCIATED PROTEIN 11-1 structural protein#PC00211 HUMAN|HGNC=1551|UniProtKB=P83916 P83916 CBX1 PTHR22812:SF164 CHROMOBOX PROTEIN CHROMOBOX PROTEIN HOMOLOG 1 chromatin binding#GO:0003682;binding#GO:0005488 negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;heterochromatin formation#GO:0031507;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;regulation of gene expression#GO:0010468;cellular component organization or biogenesis#GO:0071840;negative regulation of gene expression, epigenetic#GO:0045814;regulation of biosynthetic process#GO:0009889;negative regulation of cellular process#GO:0048523;chromatin organization#GO:0006325;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;heterochromatin organization#GO:0070828;cellular component assembly#GO:0022607;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 chromosome, centromeric region#GO:0000775;intracellular organelle#GO:0043229;heterochromatin#GO:0000792;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687;chromosome#GO:0005694;chromatin#GO:0000785;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232 HUMAN|HGNC=11652|UniProtKB=P20061 P20061 TCN1 PTHR10559:SF13 TRANSCOBALAMIN-1/GASTRIC INTRINSIC FACTOR TRANSCOBALAMIN-1 binding#GO:0005488;small molecule binding#GO:0036094;heterocyclic compound binding#GO:1901363;tetrapyrrole binding#GO:0046906 nitrogen compound transport#GO:0071705;transport#GO:0006810;establishment of localization#GO:0051234;vitamin transport#GO:0051180;localization#GO:0051179 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=15307|UniProtKB=Q8NGG6 Q8NGG6 OR8B12 PTHR48018:SF39 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 8B12 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;signal transduction#GO:0007165;cellular process#GO:0009987;cell communication#GO:0007154;sensory perception#GO:0007600;nervous system process#GO:0050877;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052;response to stimulus#GO:0050896;sensory perception of smell#GO:0007608;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=10475|UniProtKB=Q9Y230 Q9Y230 RUVBL2 PTHR11093:SF2 RUVB-RELATED REPTIN AND PONTIN RUVB-LIKE 2 catalytic activity#GO:0003824;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;macromolecular conformation isomerase activity#GO:0120543;catalytic activity, acting on DNA#GO:0140097;helicase activity#GO:0004386;isomerase activity#GO:0016853;DNA helicase activity#GO:0003678;ATP-dependent activity#GO:0140657;ATP-dependent activity, acting on DNA#GO:0008094 protein-RNA complex assembly#GO:0022618;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;chromatin remodeling#GO:0006338;ribonucleoprotein complex biogenesis#GO:0022613;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;protein-containing complex assembly#GO:0065003;protein-RNA complex organization#GO:0071826;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;regulation of gene expression#GO:0010468;cellular component assembly#GO:0022607;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;chromatin organization#GO:0006325;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular component biogenesis#GO:0044085;cellular process#GO:0009987 SWI/SNF superfamily-type complex#GO:0070603;organelle lumen#GO:0043233;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;Swr1 complex#GO:0000812;ATPase complex#GO:1904949;intracellular organelle lumen#GO:0070013;INO80-type complex#GO:0097346;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;chromatin#GO:0000785;histone deacetylase complex#GO:0000118;membrane-enclosed lumen#GO:0031974;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;Ino80 complex#GO:0031011;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228 HUMAN|HGNC=9547|UniProtKB=P62191 P62191 PSMC1 PTHR23073:SF77 26S PROTEASOME REGULATORY SUBUNIT 26S PROTEASOME REGULATORY SUBUNIT 4 macromolecular conformation isomerase activity#GO:0120543;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;polypeptide conformation or assembly isomerase activity#GO:0120544;isomerase activity#GO:0016853 ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238 endopeptidase complex#GO:1905369;catalytic complex#GO:1902494;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;proteasome complex#GO:0000502;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;peptidase complex#GO:1905368 protease#PC00190 HUMAN|HGNC=19657|UniProtKB=Q7RTS6 Q7RTS6 OTOP2 PTHR21522:SF35 PROTON CHANNEL OTOP PROTON CHANNEL OTOP2 proton channel activity#GO:0015252;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;passive transmembrane transporter activity#GO:0022803;proton transmembrane transporter activity#GO:0015078;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324 monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;monoatomic cation transport#GO:0006812;proton transmembrane transport#GO:1902600;transport#GO:0006810;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227 HUMAN|HGNC=5021|UniProtKB=P55317 P55317 FOXA1 PTHR11829:SF195 FORKHEAD BOX PROTEIN HEPATOCYTE NUCLEAR FACTOR 3-ALPHA sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700 cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;developmental process#GO:0032502;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;cellular process#GO:0009987;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 helix-turn-helix transcription factor#PC00116;gene-specific transcriptional regulator#PC00264;winged helix/forkhead transcription factor#PC00246 HUMAN|HGNC=26293|UniProtKB=Q9C093 Q9C093 SPEF2 PTHR14919:SF1 KPL2-RELATED SPERM FLAGELLA AND CILIA-ASSOCIATED PROTEIN 2 plasma membrane bounded cell projection organization#GO:0120036;male gamete generation#GO:0048232;sperm axoneme assembly#GO:0007288;cellular developmental process#GO:0048869;spermatogenesis#GO:0007283;developmental process#GO:0032502;plasma membrane bounded cell projection assembly#GO:0120031;flagellated sperm motility#GO:0030317;reproductive process#GO:0022414;cell motility#GO:0048870;microtubule-based movement#GO:0007018;germ cell development#GO:0007281;developmental process involved in reproduction#GO:0003006;multicellular organismal reproductive process#GO:0048609;axoneme assembly#GO:0035082;microtubule cytoskeleton organization#GO:0000226;anatomical structure development#GO:0048856;microtubule bundle formation#GO:0001578;spermatid development#GO:0007286;sexual reproduction#GO:0019953;organelle assembly#GO:0070925;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;cellular process#GO:0009987;cell projection assembly#GO:0030031;cilium movement involved in cell motility#GO:0060294;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;microtubule-based process#GO:0007017;motile cilium assembly#GO:0044458;cellular component organization or biogenesis#GO:0071840;cell development#GO:0048468;cellular process involved in reproduction in multicellular organism#GO:0022412;gamete generation#GO:0007276;cell projection organization#GO:0030030;cell differentiation#GO:0030154;sperm motility#GO:0097722;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cilium organization#GO:0044782;cilium-dependent cell motility#GO:0060285;sperm flagellum assembly#GO:0120316;cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;spermatid differentiation#GO:0048515 microtubule cytoskeleton#GO:0015630;organelle#GO:0043226;motile cilium#GO:0031514;cellular anatomical structure#GO:0110165;sperm flagellum#GO:0036126;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;plasma membrane bounded cell projection#GO:0120025;cytoskeleton#GO:0005856;9+2 motile cilium#GO:0097729;cilium#GO:0005929;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=23200|UniProtKB=O60381 O60381 HBP1 PTHR15499:SF3 HMG BOX-CONTAINING PROTEIN 1 HMG BOX-CONTAINING PROTEIN 1 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;HMG box transcription factor#PC00024 HUMAN|HGNC=24346|UniProtKB=Q96RT6 Q96RT6 CTAGE1 PTHR23158:SF52 MELANOMA INHIBITORY ACTIVITY-RELATED CTAGE FAMILY MEMBER 2 intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;transport#GO:0006810;establishment of localization#GO:0051234;establishment of protein localization to extracellular region#GO:0035592;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;secretion#GO:0046903;cellular localization#GO:0051641;protein secretion#GO:0009306;localization#GO:0051179;protein transport#GO:0015031;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;secretion by cell#GO:0032940;protein localization to extracellular region#GO:0071692;export from cell#GO:0140352 organelle membrane#GO:0031090;endoplasmic reticulum#GO:0005783;endoplasmic reticulum exit site#GO:0070971;endoplasmic reticulum membrane#GO:0005789;cytoplasm#GO:0005737;endomembrane system#GO:0012505;membrane#GO:0016020;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165 membrane traffic protein#PC00150 HUMAN|HGNC=22984|UniProtKB=Q9NQC1 Q9NQC1 JADE2 PTHR13793:SF84 PHD FINGER PROTEINS E3 UBIQUITIN-PROTEIN LIGASE JADE-2 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;histone reader activity#GO:0140566;chromatin-protein adaptor activity#GO:0140463 regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;chromatin organization#GO:0006325;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;chromatin remodeling#GO:0006338 protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;nucleus#GO:0005634;chromatin#GO:0000785;membraneless organelle#GO:0043228;histone acetyltransferase complex#GO:0000123;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;acetyltransferase complex#GO:1902493;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;protein acetyltransferase complex#GO:0031248 zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=6248|UniProtKB=Q9UIX4 Q9UIX4 KCNG1 PTHR11537:SF88 VOLTAGE-GATED POTASSIUM CHANNEL VOLTAGE-GATED POTASSIUM CHANNEL REGULATORY SUBUNIT KCNG1 ion channel regulator activity#GO:0099106;potassium channel regulator activity#GO:0015459;transporter regulator activity#GO:0141108;molecular function regulator activity#GO:0098772;channel regulator activity#GO:0016247 action potential#GO:0001508;metal ion transport#GO:0030001;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813;transport#GO:0006810;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391 cation channel complex#GO:0034703;voltage-gated potassium channel complex#GO:0008076;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;membrane protein complex#GO:0098796;membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 voltage-gated ion channel#PC00241;ion channel#PC00133 HUMAN|HGNC=15931|UniProtKB=O15079 O15079 SNPH PTHR16208:SF1 MICROTUBULE-ASSOCIATED PROTEIN/SYNTAPHILIN SYNTAPHILIN nervous system development#GO:0007399;cell differentiation#GO:0030154;multicellular organismal process#GO:0032501;cellular process#GO:0009987;system development#GO:0048731;neurogenesis#GO:0022008;multicellular organism development#GO:0007275;anatomical structure development#GO:0048856;cellular developmental process#GO:0048869;neuron differentiation#GO:0030182;generation of neurons#GO:0048699;developmental process#GO:0032502;animal gross anatomical part developmental process#GO:0160108 microtubule cytoskeleton#GO:0015630;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;mitochondrion#GO:0005739;cytoplasmic microtubule#GO:0005881;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membrane-bounded organelle#GO:0043227;microtubule#GO:0005874 SNARE protein#PC00034 HUMAN|HGNC=26031|UniProtKB=Q9NUD9 Q9NUD9 PIGV PTHR12468:SF2 GPI MANNOSYLTRANSFERASE 2 GPI ALPHA-1,6-MANNOSYLTRANSFERASE 2 mannosyltransferase activity#GO:0000030;glycosyltransferase activity#GO:0016757;hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740 macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;metabolic process#GO:0008152;GPI anchor metabolic process#GO:0006505;glycerophospholipid biosynthetic process#GO:0046474;lipid metabolic process#GO:0006629;GPI anchor biosynthetic process#GO:0006506;glycerophospholipid metabolic process#GO:0006650;lipid biosynthetic process#GO:0008610;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;organophosphate metabolic process#GO:0019637;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;glycolipid biosynthetic process#GO:0009247;organophosphate biosynthetic process#GO:0090407;protein metabolic process#GO:0019538;GPI anchored protein biosynthesis#GO:0180046;liposaccharide metabolic process#GO:1903509;glycerolipid metabolic process#GO:0046486;glycolipid metabolic process#GO:0006664;phospholipid biosynthetic process#GO:0008654;phospholipid metabolic process#GO:0006644;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238 membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;endoplasmic reticulum subcompartment#GO:0098827;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular protein-containing complex#GO:0140535;organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;transferase complex#GO:1990234;endoplasmic reticulum#GO:0005783;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;mannosyltransferase complex#GO:0031501;membrane#GO:0016020 protein modifying enzyme#PC00260 HUMAN|HGNC=7979|UniProtKB=P08235 P08235 NR3C2 PTHR48092:SF19 KNIRPS-RELATED PROTEIN-RELATED MINERALOCORTICOID RECEPTOR transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulatory region nucleic acid binding#GO:0001067;signaling receptor activity#GO:0038023;sequence-specific DNA binding#GO:0043565;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;nuclear receptor activity#GO:0004879;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;molecular transducer activity#GO:0060089;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of nucleobase-containing compound metabolic process#GO:0019219;nuclear receptor-mediated signaling pathway#GO:0141193;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;nuclear receptor-mediated steroid hormone signaling pathway#GO:0030518;regulation of DNA-templated transcription#GO:0006355;cell communication#GO:0007154;regulation of RNA metabolic process#GO:0051252;intracellular signal transduction#GO:0035556;response to steroid hormone#GO:0048545;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;intracellular receptor signaling pathway#GO:0030522;cellular response to stimulus#GO:0051716;steroid hormone receptor signaling pathway#GO:0043401;cellular response to steroid hormone stimulus#GO:0071383;cellular response to lipid#GO:0071396;response to lipid#GO:0033993;response to chemical#GO:0042221;response to hormone#GO:0009725;cellular process#GO:0009987;signal transduction#GO:0007165;hormone-mediated signaling pathway#GO:0009755;cellular response to chemical stimulus#GO:0070887;cellular response to hormone stimulus#GO:0032870;cellular response to endogenous stimulus#GO:0071495;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;signaling#GO:0023052;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789 nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 zinc finger transcription factor#PC00244;C4 zinc finger nuclear receptor#PC00169 HUMAN|HGNC=23490|UniProtKB=Q96E09 Q96E09 PABIR1 PTHR22227:SF14 FAMILY WITH SEQUENCE SIMILARITY 122B ISOFORM X1 PPP2R1A-PPP2R2A-INTERACTING PHOSPHATASE REGULATOR 1 phosphatase regulator activity#GO:0019208;phosphatase inhibitor activity#GO:0019212;molecular function regulator activity#GO:0098772;protein phosphatase inhibitor activity#GO:0004864;enzyme inhibitor activity#GO:0004857;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;protein phosphatase regulator activity#GO:0019888;protein serine/threonine phosphatase inhibitor activity#GO:0004865 positive regulation of catabolic process#GO:0009896;regulation of catabolic process#GO:0009894;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;regulation of proteasomal protein catabolic process#GO:0061136;positive regulation of macromolecule metabolic process#GO:0010604;biological regulation#GO:0065007;positive regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032436;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434;positive regulation of metabolic process#GO:0009893;regulation of protein catabolic process#GO:0042176;positive regulation of protein catabolic process#GO:0045732;positive regulation of protein metabolic process#GO:0051247;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of proteasomal protein catabolic process#GO:1901800;positive regulation of ubiquitin-dependent protein catabolic process#GO:2000060;regulation of biological process#GO:0050789 nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=6698|UniProtKB=O75581 O75581 LRP6 PTHR46513:SF40 VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6 developmental process#GO:0032502;animal gross anatomical part developmental process#GO:0160108;nervous system development#GO:0007399;system development#GO:0048731;multicellular organismal process#GO:0032501;anatomical structure development#GO:0048856;multicellular organism development#GO:0007275 transmembrane signal receptor#PC00197 Wnt signaling pathway#P00057>LRP5/6#P01431;Alzheimer disease-presenilin pathway#P00004>LRP#P00150;Alzheimer disease-presenilin pathway#P00004>LRP transmembrane fragment#P00152;Alzheimer disease-presenilin pathway#P00004>LRP intracellular fragment#P00173;Alzheimer disease-presenilin pathway#P00004>LRP N-terminal fragment#P00169;Alzheimer disease-presenilin pathway#P00004>LRP C-terminal fragment#P00112 HUMAN|HGNC=5210|UniProtKB=P14061 P14061 HSD17B1 PTHR43391:SF15 RETINOL DEHYDROGENASE-RELATED 17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 lipid metabolic process#GO:0006629;metabolic process#GO:0008152;regulation of biological quality#GO:0065008;estrogen metabolic process#GO:0008210;steroid biosynthetic process#GO:0006694;cellular process#GO:0009987;regulation of hormone levels#GO:0010817;primary metabolic process#GO:0044238;biological regulation#GO:0065007;biosynthetic process#GO:0009058;steroid metabolic process#GO:0008202;hormone biosynthetic process#GO:0042446;hormone metabolic process#GO:0042445;lipid biosynthetic process#GO:0008610 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 dehydrogenase#PC00092 Androgen/estrogene/progesterone biosynthesis#P02727>Estradiol 17beta-dehydrogenase#P02826 HUMAN|HGNC=25016|UniProtKB=Q9NP77 Q9NP77 SSU72 PTHR20383:SF11 RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE SSU72 hydrolase activity#GO:0016787;protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791 RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;DNA-templated transcription#GO:0006351;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA 3'-end processing#GO:0031123;macromolecule metabolic process#GO:0043170;transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;mRNA 3'-end processing#GO:0031124;termination of RNA polymerase II transcription#GO:0006369;nucleobase-containing compound biosynthetic process#GO:0034654;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;DNA-templated transcription termination#GO:0006353;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;mRNA cleavage factor complex#GO:0005849;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular organelle#GO:0043229;mRNA cleavage and polyadenylation specificity factor complex#GO:0005847;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 protein phosphatase#PC00195 HUMAN|HGNC=14303|UniProtKB=A4UGR9 A4UGR9 XIRP2 PTHR22591:SF1 XIN XIN ACTIN-BINDING REPEAT-CONTAINING PROTEIN 2 protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;actin filament binding#GO:0051015 cellular component organization or biogenesis#GO:0071840;actin filament organization#GO:0007015;supramolecular fiber organization#GO:0097435;actin filament-based process#GO:0030029;actin cytoskeleton organization#GO:0030036;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987 cell junction#GO:0030054;membraneless organelle#GO:0043228;actin filament bundle#GO:0032432;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;stress fiber#GO:0001725;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cell-substrate junction#GO:0030055;focal adhesion#GO:0005925;actin cytoskeleton#GO:0015629;actomyosin#GO:0042641 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=4712|UniProtKB=P51124 P51124 GZMM PTHR24271:SF51 KALLIKREIN-RELATED GRANZYME M endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;serine-type peptidase activity#GO:0008236 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 serine protease#PC00203 HUMAN|HGNC=24286|UniProtKB=Q9Y3A4 Q9Y3A4 RRP7A PTHR13191:SF0 RIBOSOMAL RNA PROCESSING PROTEIN 7-RELATED RIBOSOMAL RNA-PROCESSING PROTEIN 7 HOMOLOG A-RELATED RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;protein-RNA complex assembly#GO:0022618;rRNA processing#GO:0006364;organelle assembly#GO:0070925;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;ribosomal small subunit assembly#GO:0000028;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;protein-containing complex assembly#GO:0065003;RNA metabolic process#GO:0016070;ribosome assembly#GO:0042255;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;cellular component assembly#GO:0022607;gene expression#GO:0010467;RNA processing#GO:0006396;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;protein-RNA complex organization#GO:0071826;protein-containing complex organization#GO:0043933;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;ribosomal small subunit biogenesis#GO:0042274 90S preribosome#GO:0030686;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;preribosome#GO:0030684;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228 RNA metabolism protein#PC00031 HUMAN|HGNC=17170|UniProtKB=O95900 O95900 TRUB2 PTHR13195:SF0 PSEUDOURIDINE SYNTHASE-RELATED PSEUDOURIDYLATE SYNTHASE TRUB2, MITOCHONDRIAL intramolecular transferase activity#GO:0016866;catalytic activity#GO:0003824;isomerase activity#GO:0016853 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;pseudouridine synthesis#GO:0001522;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;macromolecule modification#GO:0043412;positive regulation of biosynthetic process#GO:0009891;positive regulation of translation#GO:0045727;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;positive regulation of cellular process#GO:0048522;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;post-transcriptional regulation of gene expression#GO:0010608;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulation of gene expression#GO:0010468;positive regulation of gene expression#GO:0010628;mRNA modification#GO:0016556;regulation of biological process#GO:0050789;mRNA metabolic process#GO:0016071;positive regulation of protein metabolic process#GO:0051247;RNA modification#GO:0009451;RNA metabolic process#GO:0016070;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of protein metabolic process#GO:0051246;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604;metabolic process#GO:0008152 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974 lyase#PC00144 HUMAN|HGNC=25966|UniProtKB=Q6NXG1 Q6NXG1 ESRP1 PTHR13976:SF37 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED EPITHELIAL SPLICING REGULATORY PROTEIN 1 mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 protein-containing complex#GO:0032991;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031;RNA splicing factor#PC00148;RNA processing factor#PC00147 HUMAN|HGNC=2202|UniProtKB=P02462 P02462 COL4A1 PTHR24023:SF854 COLLAGEN ALPHA COLLAGEN ALPHA-1(IV) CHAIN extracellular matrix structural constituent#GO:0005201;structural molecule activity#GO:0005198 external encapsulating structure organization#GO:0045229;cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;cellular process#GO:0009987;extracellular structure organization#GO:0043062;cellular component organization#GO:0016043 extracellular region#GO:0005576;basement membrane#GO:0005604;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical structure#GO:0110165 extracellular matrix structural protein#PC00103;extracellular matrix protein#PC00102 Integrin signalling pathway#P00034>Collagen#P00922 HUMAN|HGNC=31830|UniProtKB=Q8IYU8 Q8IYU8 MICU2 PTHR12294:SF3 EF HAND DOMAIN FAMILY A1,A2-RELATED CALCIUM UPTAKE PROTEIN 2, MITOCHONDRIAL calcium ion binding#GO:0005509;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;cation binding#GO:0043169;metal ion binding#GO:0046872 mitochondrial calcium ion transmembrane transport#GO:0006851;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;transport#GO:0006810;chemical homeostasis#GO:0048878;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;establishment of localization#GO:0051234;calcium ion transport#GO:0006816;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;intracellular monoatomic ion homeostasis#GO:0006873;calcium ion transmembrane transport#GO:0070588;mitochondrial calcium ion homeostasis#GO:0051560;homeostatic process#GO:0042592;metal ion transport#GO:0030001;calcium ion homeostasis#GO:0055074;inorganic ion homeostasis#GO:0098771;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811 mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;mitochondrial membrane#GO:0031966;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;monoatomic ion channel complex#GO:0034702;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;cation channel complex#GO:0034703;inner mitochondrial membrane protein complex#GO:0098800;transporter complex#GO:1990351;organelle membrane#GO:0031090;organelle envelope#GO:0031967;membrane protein complex#GO:0098796;mitochondrion#GO:0005739;calcium channel complex#GO:0034704;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;transmembrane transporter complex#GO:1902495;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 calcium-binding protein#PC00060;calmodulin-related#PC00061 HUMAN|HGNC=3113|UniProtKB=Q01094 Q01094 E2F1 PTHR12081:SF43 TRANSCRIPTION FACTOR E2F TRANSCRIPTION FACTOR E2F1 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575 helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=4819|UniProtKB=Q92819 Q92819 HAS2 PTHR22913:SF7 HYALURONAN SYNTHASE HYALURONAN SYNTHASE 2 catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758;glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194 external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198;polysaccharide biosynthetic process#GO:0000271;aminoglycan metabolic process#GO:0006022;extracellular structure organization#GO:0043062;carbohydrate metabolic process#GO:0005975;polysaccharide metabolic process#GO:0005976;aminoglycan biosynthetic process#GO:0006023;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;glycosaminoglycan metabolic process#GO:0030203;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;glycosaminoglycan biosynthetic process#GO:0006024;carbohydrate derivative biosynthetic process#GO:1901137;metabolic process#GO:0008152;biosynthetic process#GO:0009058;carbohydrate biosynthetic process#GO:0016051;cellular component assembly#GO:0022607;extracellular matrix assembly#GO:0085029;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transferase#PC00220;glycosyltransferase#PC00111 HUMAN|HGNC=14935|UniProtKB=Q9NRC8 Q9NRC8 SIRT7 PTHR11085:SF1 NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-7 deacetylase activity#GO:0019213;histone modifying activity#GO:0140993;acyltransferase activity#GO:0016746;NAD-dependent protein lysine deacetylase activity#GO:0034979;catalytic activity, acting on a protein#GO:0140096;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity#GO:0003824;deacylase activity#GO:0160215;transferase activity#GO:0016740;histone deacetylase activity#GO:0004407 cellular response to stress#GO:0033554;DNA damage response#GO:0006974;cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;response to stress#GO:0006950;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;chromatin remodeling#GO:0006338;chromatin organization#GO:0006325 intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;chromosome#GO:0005694;nucleus#GO:0005634;chromatin#GO:0000785;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=23728|UniProtKB=Q86WR7 Q86WR7 PROSER2 PTHR16095:SF9 TRANSMEMBRANE PROTEIN 143 FAMILY MEMBER PROLINE AND SERINE-RICH PROTEIN 2 HUMAN|HGNC=19867|UniProtKB=Q9BXE9 Q9BXE9 VN1R3 PTHR24062:SF146 VOMERONASAL TYPE-1 RECEPTOR VOMERONASAL TYPE-1 RECEPTOR 3 binding#GO:0005488 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=14240|UniProtKB=Q9NY59 Q9NY59 SMPD3 PTHR16320:SF8 SPHINGOMYELINASE FAMILY MEMBER SPHINGOMYELIN PHOSPHODIESTERASE 3 hydrolase activity, acting on ester bonds#GO:0016788;phospholipase activity#GO:0120569;catalytic activity#GO:0003824;lipase activity#GO:0016298;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;phosphoric diester hydrolase activity#GO:0008081 sphingomyelin metabolic process#GO:0006684;phospholipid metabolic process#GO:0006644;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;metabolic process#GO:0008152;sphingolipid metabolic process#GO:0006665;lipid metabolic process#GO:0006629 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=5224|UniProtKB=Q00613 Q00613 HSF1 PTHR10015:SF274 HEAT SHOCK TRANSCRIPTION FACTOR HEAT SHOCK FACTOR PROTEIN 1 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 helix-turn-helix transcription factor#PC00116;gene-specific transcriptional regulator#PC00264;winged helix/forkhead transcription factor#PC00246 HUMAN|HGNC=3044|UniProtKB=O14972 O14972 VPS26C PTHR12233:SF2 VACUOLAR PROTEIN SORTING 26 RELATED VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 26C intracellular protein localization#GO:0008104;protein transport#GO:0015031;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule localization#GO:0033036 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular vesicle#GO:0097708;vesicle#GO:0031982;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endosome#GO:0005768 membrane traffic protein#PC00150 HUMAN|HGNC=24137|UniProtKB=Q6L9W6 Q6L9W6 B4GALNT3 PTHR12369:SF15 CHONDROITIN SYNTHASE BETA-1,4-N-ACETYLGALACTOSAMINYLTRANSFERASE 3 catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;acetylgalactosaminyltransferase activity#GO:0008376 glycosyltransferase#PC00111 HUMAN|HGNC=19189|UniProtKB=Q96HP0 Q96HP0 DOCK6 PTHR23317:SF65 DEDICATOR OF CYTOKINESIS DOCK DEDICATOR OF CYTOKINESIS PROTEIN 6 guanyl-nucleotide exchange factor activity#GO:0005085;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 regulation of biological process#GO:0050789;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cell communication#GO:0010646;regulation of Rho protein signal transduction#GO:0035023;regulation of cellular process#GO:0050794;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;regulation of intracellular signal transduction#GO:1902531;regulation of small GTPase mediated signal transduction#GO:0051056 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HUMAN|HGNC=9121|UniProtKB=P54277 P54277 PMS1 PTHR10073:SF54 DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL PMS1 PROTEIN HOMOLOG 1 catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;DNA nuclease activity#GO:0004536;DNA endonuclease activity#GO:0004520;catalytic activity, acting on DNA#GO:0140097;nuclease activity#GO:0004518;endonuclease activity#GO:0004519 nucleobase-containing compound metabolic process#GO:0006139;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;mismatch repair#GO:0006298;cellular process#GO:0009987;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;cellular response to stress#GO:0033554;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281 nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 DNA metabolism protein#PC00009 HUMAN|HGNC=18284|UniProtKB=Q12829 Q12829 RAB40B PTHR47980:SF16 LD44762P RAS-RELATED PROTEIN RAB-40B protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;enzyme-substrate adaptor activity#GO:0140767;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;secretion by cell#GO:0032940;localization#GO:0051179;secretion#GO:0046903;protein metabolic process#GO:0019538;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;export from cell#GO:0140352;catabolic process#GO:0009056;transport#GO:0006810;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;exocytosis#GO:0006887;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;establishment of localization#GO:0051234;cellular process#GO:0009987;proteasomal protein catabolic process#GO:0010498;vesicle-mediated transport#GO:0016192 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cell periphery#GO:0071944;vesicle#GO:0031982;membrane#GO:0016020;intracellular vesicle#GO:0097708;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;intracellular organelle#GO:0043229 HUMAN|HGNC=25392|UniProtKB=Q3ZCX4 Q3ZCX4 ZNF568 PTHR24377:SF993 IP01015P-RELATED ZINC FINGER PROTEIN 568 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=11407|UniProtKB=Q9BXU1 Q9BXU1 STK31 PTHR12302:SF3 EBNA2 BINDING PROTEIN P100 SERINE_THREONINE-PROTEIN KINASE 31 catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;nuclease activity#GO:0004518;RNA nuclease activity#GO:0004540;endonuclease activity#GO:0004519;RNA endonuclease activity#GO:0004521;catalytic activity, acting on RNA#GO:0140098 RNA catabolic process#GO:0006401;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;nucleic acid catabolic process#GO:0141188;cellular process#GO:0009987;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;nucleobase-containing compound catabolic process#GO:0034655;nucleobase-containing compound metabolic process#GO:0006139;catabolic process#GO:0009056 HUMAN|HGNC=24003|UniProtKB=Q8WXA8 Q8WXA8 HTR3C PTHR18945:SF931 NEUROTRANSMITTER GATED ION CHANNEL 5-HYDROXYTRYPTAMINE RECEPTOR 3C monoatomic cation channel activity#GO:0005261;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;molecular transducer activity#GO:0060089;channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic ion channel activity#GO:0005216;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion transmembrane transporter activity#GO:0015075;signaling receptor activity#GO:0038023;neurotransmitter receptor activity#GO:0030594;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;transmembrane signaling receptor activity#GO:0004888;gated channel activity#GO:0022836 cellular process#GO:0009987;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;synaptic signaling#GO:0099536;response to chemical#GO:0042221;calcium ion transport#GO:0006816;regulation of membrane potential#GO:0042391;regulation of biological process#GO:0050789;signaling#GO:0023052;response to stimulus#GO:0050896;response to oxygen-containing compound#GO:1901700;cellular response to chemical stimulus#GO:0070887;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;monoatomic ion transmembrane transport#GO:0034220;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;cellular response to nitrogen compound#GO:1901699;synaptic transmission, cholinergic#GO:0007271;transport#GO:0006810;establishment of localization#GO:0051234;cellular response to stimulus#GO:0051716;chemical synaptic transmission#GO:0007268;metal ion transport#GO:0030001;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;trans-synaptic signaling#GO:0099537;response to nitrogen compound#GO:1901698;cell communication#GO:0007154;monoatomic cation transport#GO:0006812;localization#GO:0051179 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane protein complex#GO:0098796;membrane#GO:0016020;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;cation channel complex#GO:0034703;signaling receptor complex#GO:0043235 ligand-gated ion channel#PC00141 5HT3 type receptor mediated signaling pathway#P04375>5HT3 Rec#P04422 HUMAN|HGNC=26232|UniProtKB=Q96AH0 Q96AH0 NABP1 PTHR13356:SF5 OB FOLD NUCLEIC ACID BINDING PROTEIN-RELATED SOSS COMPLEX SUBUNIT B2 nucleic acid binding#GO:0003676;binding#GO:0005488;DNA binding#GO:0003677 regulation of cell cycle G2/M phase transition#GO:1902749;regulation of mitotic cell cycle#GO:0007346;response to radiation#GO:0009314;mitotic G2/M transition checkpoint#GO:0044818;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of cellular process#GO:0048523;DNA repair#GO:0006281;negative regulation of cell cycle process#GO:0010948;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;mitotic cell cycle process#GO:1903047;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mitotic cell cycle checkpoint signaling#GO:0007093;cell cycle#GO:0007049;regulation of cell cycle phase transition#GO:1901987;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;mitotic cell cycle#GO:0000278;recombinational repair#GO:0000725;cell communication#GO:0007154;regulation of G2/M transition of mitotic cell cycle#GO:0010389;intracellular signal transduction#GO:0035556;response to stress#GO:0006950;cellular process#GO:0009987;signal transduction#GO:0007165;negative regulation of G2/M transition of mitotic cell cycle#GO:0010972;negative regulation of mitotic cell cycle phase transition#GO:1901991;cell cycle checkpoint signaling#GO:0000075;regulation of cell cycle process#GO:0010564;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA recombination#GO:0006310;negative regulation of cell cycle#GO:0045786;negative regulation of cell cycle G2/M phase transition#GO:1902750;double-strand break repair#GO:0006302;negative regulation of cell cycle phase transition#GO:1901988;response to abiotic stimulus#GO:0009628;negative regulation of biological process#GO:0048519;cell cycle process#GO:0022402;double-strand break repair via homologous recombination#GO:0000724;response to ionizing radiation#GO:0010212;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signaling#GO:0023052;regulation of cell cycle#GO:0051726;cellular response to stress#GO:0033554;regulation of mitotic cell cycle phase transition#GO:1901990;negative regulation of mitotic cell cycle#GO:0045930 organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 DNA metabolism protein#PC00009;damaged DNA-binding protein#PC00086 HUMAN|HGNC=10635|UniProtKB=P80075 P80075 CCL8 PTHR12015:SF209 SMALL INDUCIBLE CYTOKINE A C-C MOTIF CHEMOKINE 8 receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;chemokine activity#GO:0008009;G protein-coupled receptor binding#GO:0001664;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;signaling receptor binding#GO:0005102;binding#GO:0005488;cytokine receptor binding#GO:0005126;cytokine activity#GO:0005125;chemokine receptor binding#GO:0042379;protein binding#GO:0005515;molecular function activator activity#GO:0140677 cell surface receptor signaling pathway#GO:0007166;antimicrobial humoral response#GO:0019730;humoral immune response#GO:0006959;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;defense response to symbiont#GO:0140546;signal transduction#GO:0007165;response to stress#GO:0006950;response to chemokine#GO:1990868;response to biotic stimulus#GO:0009607;granulocyte migration#GO:0097530;defense response to other organism#GO:0098542;response to chemical#GO:0042221;taxis#GO:0042330;response to cytokine#GO:0034097;immune system process#GO:0002376;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;response to peptide#GO:1901652;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;positive regulation of cell motility#GO:2000147;biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052;granulocyte chemotaxis#GO:0071621;response to stimulus#GO:0050896;regulation of cell migration#GO:0030334;leukocyte migration#GO:0050900;leukocyte chemotaxis#GO:0030595;defense response#GO:0006952;myeloid leukocyte migration#GO:0097529;positive regulation of locomotion#GO:0040017;response to external stimulus#GO:0009605;positive regulation of cell migration#GO:0030335;positive regulation of cellular process#GO:0048522;immune response#GO:0006955;regulation of locomotion#GO:0040012;response to other organism#GO:0051707;biological regulation#GO:0065007;cell migration#GO:0016477;chemotaxis#GO:0006935;inflammatory response#GO:0006954;cytokine-mediated signaling pathway#GO:0019221;cell chemotaxis#GO:0060326;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;cell communication#GO:0007154;regulation of cell motility#GO:2000145;chemokine-mediated signaling pathway#GO:0070098;cellular response to stimulus#GO:0051716;locomotion#GO:0040011;cellular response to chemokine#GO:1990869;response to external biotic stimulus#GO:0043207;cell motility#GO:0048870;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 cytokine#PC00083 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CHK#P00856 HUMAN|HGNC=29172|UniProtKB=Q9UPX6 Q9UPX6 MINAR1 PTHR31530:SF2 MAJOR INTRINSICALLY DISORDERED NOTCH2-BINDING RECEPTOR 1 MINAR1 FAMILY MEMBER MAJOR INTRINSICALLY DISORDERED NOTCH2-BINDING RECEPTOR 1 negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;regulation of cell population proliferation#GO:0042127;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of TOR signaling#GO:0032007;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;negative regulation of cell population proliferation#GO:0008285;regulation of TOR signaling#GO:0032006;negative regulation of response to stimulus#GO:0048585;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=9352|UniProtKB=Q06830 Q06830 PRDX1 PTHR10681:SF111 THIOREDOXIN PEROXIDASE PEROXIREDOXIN-1 antioxidant activity#GO:0016209;peroxidase activity#GO:0004601;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on peroxide as acceptor#GO:0016684 cellular response to stimulus#GO:0051716;response to toxic substance#GO:0009636;catabolic process#GO:0009056;response to stimulus#GO:0050896;hydrogen peroxide metabolic process#GO:0042743;homeostatic process#GO:0042592;cellular response to chemical stimulus#GO:0070887;cellular detoxification#GO:1990748;response to oxygen-containing compound#GO:1901700;cellular response to stress#GO:0033554;response to stress#GO:0006950;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;cellular oxidant detoxification#GO:0098869;cellular response to oxidative stress#GO:0034599;response to chemical#GO:0042221;cellular response to toxic substance#GO:0097237;detoxification#GO:0098754;reactive oxygen species metabolic process#GO:0072593;metabolic process#GO:0008152;cellular response to chemical stress#GO:0062197;response to oxidative stress#GO:0006979;superoxide metabolic process#GO:0006801;response to reactive oxygen species#GO:0000302;cellular homeostasis#GO:0019725;cell redox homeostasis#GO:0045454 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 oxidoreductase#PC00176;peroxidase#PC00180 HUMAN|HGNC=3252|UniProtKB=O14602 O14602 EIF1AY PTHR21668:SF17 EIF-1A EUKARYOTIC TRANSLATION INITIATION FACTOR 1A, Y-CHROMOSOMAL translation initiation factor activity#GO:0003743;translation factor activity#GO:0180051 protein biosynthetic process#GO:0160307;gene expression#GO:0010467;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;translational initiation#GO:0006413;translation#GO:0006412 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 translational protein#PC00263;translation initiation factor#PC00224;translation factor#PC00223 HUMAN|HGNC=248|UniProtKB=Q99541 Q99541 PLIN2 PTHR14024:SF25 PERILIPIN PERILIPIN-2 regulation of localization#GO:0032879;cellular process#GO:0009987;lipid storage#GO:0019915;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789;biological regulation#GO:0065007;regulation of cellular process#GO:0050794 intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;lipid droplet#GO:0005811;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737 scaffold/adaptor protein#PC00226 HUMAN|HGNC=27678|UniProtKB=Q86YG4 Q86YG4 NT5DC4 PTHR12103:SF18 5'-NUCLEOTIDASE DOMAIN-CONTAINING 5'-NUCLEOTIDASE DOMAIN-CONTAINING PROTEIN 4 phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;nucleotidase activity#GO:0008252;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;5'-nucleotidase activity#GO:0008253 nucleoside phosphate catabolic process#GO:1901292;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;carbohydrate derivative catabolic process#GO:1901136;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;purine-containing compound metabolic process#GO:0072521;purine ribonucleotide catabolic process#GO:0009154;purine nucleotide metabolic process#GO:0006163;nucleotide metabolic process#GO:0009117;organophosphate catabolic process#GO:0046434;ribonucleotide metabolic process#GO:0009259;purine nucleotide catabolic process#GO:0006195;nucleobase-containing compound metabolic process#GO:0006139;organophosphate metabolic process#GO:0019637;nucleobase-containing compound catabolic process#GO:0034655;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;carbohydrate derivative metabolic process#GO:1901135;ribonucleotide catabolic process#GO:0009261;purine-containing compound catabolic process#GO:0072523;nucleobase-containing small molecule metabolic process#GO:0055086;purine ribonucleotide metabolic process#GO:0009150;nucleotide catabolic process#GO:0009166;metabolic process#GO:0008152 phosphatase#PC00181;hydrolase#PC00121;nucleotide phosphatase#PC00173 HUMAN|HGNC=25240|UniProtKB=Q4KMQ2 Q4KMQ2 ANO6 PTHR12308:SF21 ANOCTAMIN ANOCTAMIN-6 monoatomic cation channel activity#GO:0005261;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;monoatomic ion-gated channel activity#GO:0022839;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;intramembrane lipid carrier activity#GO:0140303;calcium-activated cation channel activity#GO:0005227;channel activity#GO:0015267;lipid carrier activity#GO:0005319;phospholipid scramblase activity#GO:0017128;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;molecular carrier activity#GO:0140104;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836 lipid localization#GO:0010876;transmembrane transport#GO:0055085;localization#GO:0051179;chloride transmembrane transport#GO:1902476;plasma membrane organization#GO:0007009;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;inorganic anion transport#GO:0015698;cellular component organization#GO:0016043;monoatomic anion transport#GO:0006820;organophosphate ester transport#GO:0015748;plasma membrane phospholipid scrambling#GO:0017121;lipid translocation#GO:0034204;chloride transport#GO:0006821;transport#GO:0006810;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;regulation of membrane lipid distribution#GO:0097035;macromolecule localization#GO:0033036;cellular process#GO:0009987;monoatomic anion transmembrane transport#GO:0098656;lipid transport#GO:0006869;monoatomic ion transmembrane transport#GO:0034220;endomembrane system organization#GO:0010256;biological regulation#GO:0065007;membrane organization#GO:0061024;phospholipid translocation#GO:0045332;phospholipid transport#GO:0015914 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=14970|UniProtKB=Q9UNH7 Q9UNH7 SNX6 PTHR45850:SF4 SORTING NEXIN FAMILY MEMBER SORTING NEXIN-6 protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;binding#GO:0005488 endosomal transport#GO:0016197;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;transport#GO:0006810;intracellular transport#GO:0046907;cytosolic transport#GO:0016482;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;retrograde transport, endosome to Golgi#GO:0042147 endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 scaffold/adaptor protein#PC00226 HUMAN|HGNC=6456|UniProtKB=O76015 O76015 KRT38 PTHR23239:SF387 INTERMEDIATE FILAMENT KERATIN, TYPE I CUTICULAR HA8 structural molecule activity#GO:0005198 tissue development#GO:0009888;epithelial cell differentiation#GO:0030855;epithelium development#GO:0060429;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular process#GO:0009987;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;morphogenesis of an epithelium#GO:0002009;developmental process#GO:0032502;intermediate filament cytoskeleton organization#GO:0045104;cell differentiation#GO:0030154;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;tissue morphogenesis#GO:0048729;supramolecular fiber organization#GO:0097435;animal gross anatomical part developmental process#GO:0160108;intermediate filament-based process#GO:0045103;intermediate filament organization#GO:0045109 membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;supramolecular fiber#GO:0099512;intermediate filament#GO:0005882;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;organelle#GO:0043226;supramolecular complex#GO:0099080;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232 intermediate filament#PC00129 HUMAN|HGNC=9011|UniProtKB=Q9P0L9 Q9P0L9 PKD2L1 PTHR10877:SF196 POLYCYSTIN FAMILY MEMBER POLYCYSTIN-2-LIKE PROTEIN 1 ligand-gated channel activity#GO:0022834;calcium-activated potassium channel activity#GO:0015269;passive transmembrane transporter activity#GO:0022803;monoatomic ion-gated channel activity#GO:0022839;calcium channel activity#GO:0005262;transmembrane transporter activity#GO:0022857;sodium channel activity#GO:0005272;ligand-gated monoatomic cation channel activity#GO:0099094;monoatomic cation channel activity#GO:0005261;sodium ion transmembrane transporter activity#GO:0015081;ion binding#GO:0043167;small molecule binding#GO:0036094;ligand-gated monoatomic ion channel activity#GO:0015276;potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;cation binding#GO:0043169;channel activity#GO:0015267;calcium-activated cation channel activity#GO:0005227;transporter activity#GO:0005215;cytoskeletal protein binding#GO:0008092;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873;binding#GO:0005488;calcium ion binding#GO:0005509;gated channel activity#GO:0022836;protein binding#GO:0005515;metal ion binding#GO:0046872;calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324 metal ion transport#GO:0030001;response to stimulus#GO:0050896;response to abiotic stimulus#GO:0009628;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813;response to mechanical stimulus#GO:0009612;cellular process#GO:0009987;detection of stimulus#GO:0051606;response to external stimulus#GO:0009605;establishment of localization#GO:0051234;transport#GO:0006810;detection of mechanical stimulus#GO:0050982 membrane#GO:0016020;cellular anatomical structure#GO:0110165 ion channel#PC00133 HUMAN|HGNC=29064|UniProtKB=A8K8P3 A8K8P3 SFI1 PTHR22028:SF4 SFI1 SPINDLE BODY DOMAIN-CONTAINING PROTEIN-RELATED PROTEIN SFI1 HOMOLOG protein binding#GO:0005515;binding#GO:0005488;phosphatase binding#GO:0019902;enzyme binding#GO:0019899 HUMAN|HGNC=27119|UniProtKB=Q17RN3 Q17RN3 FAM98C PTHR31353:SF10 FAM98 PROTEIN FAM98C protein-containing complex#GO:0032991;intracellular protein-containing complex#GO:0140535;catalytic complex#GO:1902494 RNA splicing factor#PC00148;RNA processing factor#PC00147 HUMAN|HGNC=12553|UniProtKB=P06133 P06133 UGT2B4 PTHR48043:SF164 EG:EG0003.4 PROTEIN-RELATED UDP-GLUCURONOSYLTRANSFERASE 2B4 glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194;catalytic activity#GO:0003824;glucuronosyltransferase activity#GO:0015020;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758 lipid metabolic process#GO:0006629;metabolic process#GO:0008152;regulation of biological quality#GO:0065008;estrogen metabolic process#GO:0008210;regulation of hormone levels#GO:0010817;cellular process#GO:0009987;primary metabolic process#GO:0044238;biological regulation#GO:0065007;steroid metabolic process#GO:0008202;hormone metabolic process#GO:0042445 HUMAN|HGNC=7150|UniProtKB=O95822 O95822 MLYCD PTHR28641:SF1 FAMILY NOT NAMED MALONYL-COA DECARBOXYLASE, MITOCHONDRIAL HUMAN|HGNC=16012|UniProtKB=Q96Q27 Q96Q27 ASB2 PTHR24189:SF77 MYOTROPHIN ANKYRIN REPEAT AND SOCS BOX PROTEIN 2 regulation of protein depolymerization#GO:1901879;cellular component organization or biogenesis#GO:0071840;regulation of anatomical structure size#GO:0090066;regulation of actin filament-based process#GO:0032970;regulation of actin polymerization or depolymerization#GO:0008064;biological regulation#GO:0065007;regulation of actin cytoskeleton organization#GO:0032956;regulation of actin filament polymerization#GO:0030833;regulation of actin filament organization#GO:0110053;cellular process#GO:0009987;regulation of protein-containing complex disassembly#GO:0043244;regulation of biological quality#GO:0065008;regulation of actin filament length#GO:0030832;regulation of actin filament depolymerization#GO:0030834;regulation of cellular component biogenesis#GO:0044087;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;regulation of protein polymerization#GO:0032271;regulation of cellular process#GO:0050794;regulation of cellular component size#GO:0032535;regulation of supramolecular fiber organization#GO:1902903;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;regulation of protein-containing complex assembly#GO:0043254;cellular component organization#GO:0016043 nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=14867|UniProtKB=Q9BPW4 Q9BPW4 APOL4 PTHR14096:SF39 APOLIPOPROTEIN L APOLIPOPROTEIN L4 binding#GO:0005488;lipid binding#GO:0008289 cellular anatomical structure#GO:0110165;membrane#GO:0016020 transfer/carrier protein#PC00219;apolipoprotein#PC00052 HUMAN|HGNC=29934|UniProtKB=Q6ZQQ6 Q6ZQQ6 WDR87 PTHR42968:SF9 WD REPEAT-CONTAINING WD REPEAT-CONTAINING PROTEIN 87 scaffold/adaptor protein#PC00226 HUMAN|HGNC=16244|UniProtKB=Q8NDH3 Q8NDH3 NPEPL1 PTHR11963:SF4 LEUCINE AMINOPEPTIDASE-RELATED AMINOPEPTIDASE NPEPL1-RELATED catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233 metabolic process#GO:0008152;proteolysis#GO:0006508;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 metalloprotease#PC00153;protease#PC00190 HUMAN|HGNC=10730|UniProtKB=Q9NPR2 Q9NPR2 SEMA4B PTHR11036:SF14 SEMAPHORIN SEMAPHORIN-4B molecular function activator activity#GO:0140677;protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545 cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;response to chemical#GO:0042221;taxis#GO:0042330;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;neuron projection development#GO:0031175;cell projection morphogenesis#GO:0048858;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cell surface receptor signaling pathway#GO:0007166;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;cell development#GO:0048468;signaling#GO:0023052;cell morphogenesis#GO:0000902;response to stimulus#GO:0050896;cell differentiation#GO:0030154;cell projection organization#GO:0030030;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;positive regulation of cell motility#GO:2000147;axonogenesis#GO:0007409;neuron development#GO:0048666;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;plasma membrane bounded cell projection organization#GO:0120036;regulation of locomotion#GO:0040012;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;positive regulation of cell migration#GO:0030335;positive regulation of cellular process#GO:0048522;axon guidance#GO:0007411;axon development#GO:0061564;neurogenesis#GO:0022008;positive regulation of locomotion#GO:0040017;neuron projection guidance#GO:0097485;response to external stimulus#GO:0009605;cellular developmental process#GO:0048869;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;regulation of cell migration#GO:0030334;locomotion#GO:0040011;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;system development#GO:0048731;anatomical structure development#GO:0048856;cell communication#GO:0007154;regulation of cell motility#GO:2000145;chemotaxis#GO:0006935 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 membrane-bound signaling molecule#PC00152 HUMAN|HGNC=23049|UniProtKB=Q9NS93 Q9NS93 TM7SF3 PTHR15937:SF3 TRANSMEMBRANE 7 SUPERFAMILY MEMBER 3 TRANSMEMBRANE 7 SUPERFAMILY MEMBER 3 negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;negative regulation of cellular process#GO:0048523;negative regulation of programmed cell death#GO:0043069;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;biological regulation#GO:0065007 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=7807|UniProtKB=Q8N5V2 Q8N5V2 NGEF PTHR12845:SF8 GUANINE NUCLEOTIDE EXCHANGE FACTOR EPHEXIN-1 guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695 regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;biological regulation#GO:0065007;regulation of actin cytoskeleton organization#GO:0032956;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794;regulation of actin filament-based process#GO:0032970 protein-binding activity modulator#PC00095;G-protein modulator#PC00022;guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=13430|UniProtKB=Q9Y577 Q9Y577 TRIM17 PTHR24103:SF397 E3 UBIQUITIN-PROTEIN LIGASE TRIM E3 UBIQUITIN-PROTEIN LIGASE TRIM17 catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630 response to external stimulus#GO:0009605;defense response#GO:0006952;regulation of gene expression#GO:0010468;innate immune response#GO:0045087;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;response to other organism#GO:0051707;defense response to other organism#GO:0098542;immune response#GO:0006955;defense response to symbiont#GO:0140546;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;immune system process#GO:0002376;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=25222|UniProtKB=Q96DZ1 Q96DZ1 ERLEC1 PTHR15414:SF0 OS-9-RELATED ENDOPLASMIC RETICULUM LECTIN 1 macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;response to chemical#GO:0042221;proteasomal protein catabolic process#GO:0010498;response to stress#GO:0006950;cellular process#GO:0009987;signal transduction#GO:0007165;cellular localization#GO:0051641;response to unfolded protein#GO:0006986;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;signaling#GO:0023052;response to topologically incorrect protein#GO:0035966;regulation of biological process#GO:0050789;macromolecule metabolic process#GO:0043170;intracellular protein localization#GO:0008104;biological regulation#GO:0065007;endoplasmic reticulum unfolded protein response#GO:0030968;macromolecule localization#GO:0033036;protein metabolic process#GO:0019538;localization#GO:0051179;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;ERAD pathway#GO:0036503;response to endoplasmic reticulum stress#GO:0034976;cellular response to unfolded protein#GO:0034620;cellular response to topologically incorrect protein#GO:0035967;regulation of cellular process#GO:0050794;protein localization to organelle#GO:0033365;catabolic process#GO:0009056;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716 intracellular organelle lumen#GO:0070013;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;endoplasmic reticulum lumen#GO:0005788;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=6869|UniProtKB=Q14244 Q14244 MAP7 PTHR15073:SF4 MICROTUBULE-ASSOCIATED PROTEIN ENSCONSIN regulation of cellular process#GO:0050794;regulation of microtubule-based movement#GO:0060632;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;regulation of biological process#GO:0050789;microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;regulation of microtubule-based process#GO:0032886;microtubule bundle formation#GO:0001578 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;microtubule cytoskeleton#GO:0015630 non-motor microtubule binding protein#PC00166 HUMAN|HGNC=20365|UniProtKB=Q9C0C6 Q9C0C6 CIPC PTHR34648:SF1 CLOCK-INTERACTING PACEMAKER CLOCK-INTERACTING PACEMAKER negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=18806|UniProtKB=Q9Y6Y1 Q9Y6Y1 CAMTA1 PTHR23335:SF11 CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR CAMTA CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR 1 double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;binding#GO:0005488;nucleic acid binding#GO:0003676 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=6443|UniProtKB=P02538 P02538 KRT6A PTHR45616:SF39 GATA-TYPE DOMAIN-CONTAINING PROTEIN KERATIN, TYPE II CYTOSKELETAL 6A-RELATED structural molecule activity#GO:0005198 intermediate filament cytoskeleton organization#GO:0045104;cell differentiation#GO:0030154;cellular component organization#GO:0016043;supramolecular fiber organization#GO:0097435;anatomical structure development#GO:0048856;intermediate filament organization#GO:0045109;animal gross anatomical part developmental process#GO:0160108;keratinocyte differentiation#GO:0030216;intermediate filament-based process#GO:0045103;cytoskeleton organization#GO:0007010;skin development#GO:0043588;tissue development#GO:0009888;epidermal cell differentiation#GO:0009913;multicellular organismal process#GO:0032501;epithelial cell differentiation#GO:0030855;epithelium development#GO:0060429;cellular process#GO:0009987;organelle organization#GO:0006996;cellular developmental process#GO:0048869;animal organ development#GO:0048513;cellular component organization or biogenesis#GO:0071840;developmental process#GO:0032502;epidermis development#GO:0008544 cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;organelle#GO:0043226;supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;intermediate filament#GO:0005882 HUMAN|HGNC=15561|UniProtKB=Q9UBH0 Q9UBH0 IL36RN PTHR10078:SF32 INTERLEUKIN-1 FAMILY MEMBER INTERLEUKIN-36 RECEPTOR ANTAGONIST PROTEIN receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;cytokine activity#GO:0005125;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677 cellular response to molecule of bacterial origin#GO:0071219;response to external stimulus#GO:0009605;defense response#GO:0006952;immune response#GO:0006955;biological regulation#GO:0065007;response to other organism#GO:0051707;cytokine-mediated signaling pathway#GO:0019221;response to bacterium#GO:0009617;inflammatory response#GO:0006954;cell communication#GO:0007154;cellular response to biotic stimulus#GO:0071216;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;response to external biotic stimulus#GO:0043207;cell surface receptor signaling pathway#GO:0007166;response to lipopolysaccharide#GO:0032496;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;cellular response to lipopolysaccharide#GO:0071222;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;cellular process#GO:0009987;response to cytokine#GO:0034097;response to chemical#GO:0042221;cellular response to lipid#GO:0071396;response to lipid#GO:0033993;immune system process#GO:0002376;cellular response to chemical stimulus#GO:0070887;response to oxygen-containing compound#GO:1901700;response to peptide#GO:1901652;response to molecule of bacterial origin#GO:0002237;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 interleukin superfamily#PC00128;cytokine#PC00083;intercellular signal molecule#PC00207 HUMAN|HGNC=15508|UniProtKB=Q9Y606 Q9Y606 PUS1 PTHR11142:SF4 PSEUDOURIDYLATE SYNTHASE PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG catalytic activity#GO:0003824;intramolecular transferase activity#GO:0016866;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a tRNA#GO:0140101;isomerase activity#GO:0016853 gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;tRNA modification#GO:0006400;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA modification#GO:0016556;pseudouridine synthesis#GO:0001522;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 lyase#PC00144 HUMAN|HGNC=7136|UniProtKB=P42568 P42568 MLLT3 PTHR47827:SF5 AHD DOMAIN-CONTAINING PROTEIN PROTEIN AF-9 binding#GO:0005488;chromatin binding#GO:0003682 regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of biological process#GO:0050789;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219 organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;protein-containing complex#GO:0032991;transcription elongation factor complex#GO:0008023;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 HUMAN|HGNC=23168|UniProtKB=Q8IYD8 Q8IYD8 FANCM PTHR14025:SF20 FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER FANCONI ANEMIA GROUP M PROTEIN ATP-dependent activity#GO:0140657;nucleic acid binding#GO:0003676;binding#GO:0005488;four-way junction DNA binding#GO:0000400;ATP-dependent activity, acting on DNA#GO:0008094;DNA binding#GO:0003677;macromolecular conformation isomerase activity#GO:0120543;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity#GO:0003824;DNA helicase activity#GO:0003678;3'-5' DNA helicase activity#GO:0043138;isomerase activity#GO:0016853;helicase activity#GO:0004386;catalytic activity, acting on DNA#GO:0140097 macromolecule metabolic process#GO:0043170;double-strand break repair#GO:0006302;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;DNA recombination#GO:0006310;DNA damage response#GO:0006974;interstrand cross-link repair#GO:0036297;nucleobase-containing compound metabolic process#GO:0006139;response to stress#GO:0006950;cellular process#GO:0009987;recombinational repair#GO:0000725;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular response to stimulus#GO:0051716;double-strand break repair via homologous recombination#GO:0000724 DNA metabolism protein#PC00009 HUMAN|HGNC=7799|UniProtKB=O00221 O00221 NFKBIE PTHR24118:SF37 POTE ANKYRIN DOMAIN NF-KAPPA-B INHIBITOR EPSILON protein sequestering activity#GO:0140311;molecular sequestering activity#GO:0140313 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 membrane traffic protein#PC00150 Toll receptor signaling pathway#P00054>IkappaB#P01338;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>NFkappaB#P00859 HUMAN|HGNC=24470|UniProtKB=Q86SG2 Q86SG2 ANKRD23 PTHR24193:SF121 ANKYRIN REPEAT PROTEIN ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 23 HUMAN|HGNC=8769|UniProtKB=Q9NP92 Q9NP92 MRPS30 PTHR13014:SF3 MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S30/P52 PRO-APOTOTIC PROTEIN LARGE RIBOSOMAL SUBUNIT PROTEIN ML65 mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;large ribosomal subunit#GO:0015934;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;mitochondrial ribosome#GO:0005761;intracellular anatomical structure#GO:0005622;organellar ribosome#GO:0000313;membrane-bounded organelle#GO:0043227;ribosome#GO:0005840;mitochondrion#GO:0005739;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;membraneless organelle#GO:0043228;mitochondrial large ribosomal subunit#GO:0005762;membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991 ribosomal protein#PC00202;translational protein#PC00263 HUMAN|HGNC=6606|UniProtKB=Q8N423 Q8N423 LILRB2 PTHR11738:SF170 MHC CLASS I NK CELL RECEPTOR LEUKOCYTE IMMUNOGLOBULIN-LIKE RECEPTOR SUBFAMILY A MEMBER 3-RELATED molecular transducer activity#GO:0060089;immune receptor activity#GO:0140375;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;cellular process#GO:0009987;response to chemical#GO:0042221;response to cytokine#GO:0034097;immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007;cell surface receptor signaling pathway#GO:0007166;regulation of response to stimulus#GO:0048583;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;immune response-regulating signaling pathway#GO:0002764;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;signaling#GO:0023052;cytokine-mediated signaling pathway#GO:0019221;regulation of immune response#GO:0050776;cell communication#GO:0007154;response to peptide#GO:1901652 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=28602|UniProtKB=Q7L0X2 Q7L0X2 ERICH6 PTHR23093:SF11 SIMILAR TO CHROMOSOME 3 OPEN READING FRAME 20 GLUTAMATE-RICH PROTEIN 6 HUMAN|HGNC=19721|UniProtKB=Q8WVQ1 Q8WVQ1 CANT1 PTHR13023:SF3 APYRASE SOLUBLE CALCIUM-ACTIVATED NUCLEOTIDASE 1 hydrolase activity#GO:0016787;nucleoside diphosphate phosphatase activity#GO:0017110;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462 proteoglycan metabolic process#GO:0006029;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;biosynthetic process#GO:0009058;proteoglycan biosynthetic process#GO:0030166;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101 membrane#GO:0016020;cellular anatomical structure#GO:0110165 hydrolase#PC00121;nucleotide phosphatase#PC00173 HUMAN|HGNC=35422|UniProtKB=A8MQ27 A8MQ27 NEURL1B PTHR12429:SF10 NEURALIZED E3 UBIQUITIN-PROTEIN LIGASE NEURL1B acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 regulation of Notch signaling pathway#GO:0008593;regulation of signaling#GO:0023051;localization#GO:0051179;protein transport#GO:0015031;regulation of biological process#GO:0050789;protein localization to organelle#GO:0033365;regulation of cellular process#GO:0050794;endocytosis#GO:0006897;regulation of cell communication#GO:0010646;transport#GO:0006810;regulation of response to stimulus#GO:0048583;establishment of localization#GO:0051234;import into cell#GO:0098657;establishment of protein localization to organelle#GO:0072594;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;establishment of protein localization#GO:0045184;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007 membrane-bounded organelle#GO:0043227;early endosome#GO:0005769;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=9053|UniProtKB=Q03405 Q03405 PLAUR PTHR10624:SF6 UROKINASE PLASMINOGEN ACTIVATOR SURFACE RECEPTOR-RELATED UROKINASE PLASMINOGEN ACTIVATOR SURFACE RECEPTOR membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 Plasminogen activating cascade#P00050>uPAR#P01256;Blood coagulation#P00011>uPAR#P00433 HUMAN|HGNC=4424|UniProtKB=Q92805 Q92805 GOLGA1 PTHR23157:SF24 GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1 GOLGIN SUBFAMILY A MEMBER 1 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=4134|UniProtKB=O60755 O60755 GALR3 PTHR24230:SF17 G-PROTEIN COUPLED RECEPTOR GALANIN RECEPTOR TYPE 3 neuropeptide receptor activity#GO:0008188;transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 neuropeptide signaling pathway#GO:0007218;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021 HUMAN|HGNC=25373|UniProtKB=Q9H0Q0 Q9H0Q0 CYRIA PTHR12422:SF4 GH09096P CYFIP-RELATED RAC1 INTERACTOR A HUMAN|HGNC=12437|UniProtKB=Q16881 Q16881 TXNRD1 PTHR48105:SF7 THIOREDOXIN REDUCTASE 1-RELATED-RELATED THIOREDOXIN REDUCTASE 1, CYTOPLASMIC disulfide oxidoreductase activity#GO:0015036;protein-disulfide reductase activity#GO:0015035;oxidoreductase activity#GO:0016491;catalytic activity, acting on a protein#GO:0140096;antioxidant activity#GO:0016209;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;catalytic activity#GO:0003824 cell redox homeostasis#GO:0045454;homeostatic process#GO:0042592;cellular homeostasis#GO:0019725 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;cytosol#GO:0005829;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 oxidoreductase#PC00176;reductase#PC00198 HUMAN|HGNC=6623|UniProtKB=Q9Y5X9 Q9Y5X9 LIPG PTHR11610:SF13 LIPASE ENDOTHELIAL LIPASE hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;lipase activity#GO:0016298;catalytic activity#GO:0003824 lipid catabolic process#GO:0016042;lipid metabolic process#GO:0006629;cellular process#GO:0009987;metabolic process#GO:0008152;primary metabolic process#GO:0044238;catabolic process#GO:0009056 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 metabolite interconversion enzyme#PC00262;lipase#PC00143;hydrolase#PC00121 HUMAN|HGNC=30071|UniProtKB=Q8IZA0 Q8IZA0 KIAA0319L PTHR46182:SF3 FI19480P1 DYSLEXIA-ASSOCIATED PROTEIN KIAA0319-LIKE PROTEIN anatomical structure development#GO:0048856;cellular developmental process#GO:0048869;neuron migration#GO:0001764;multicellular organism development#GO:0007275;neurogenesis#GO:0022008;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;developmental process#GO:0032502;multicellular organismal process#GO:0032501;cell motility#GO:0048870;cell migration#GO:0016477;cell differentiation#GO:0030154;nervous system development#GO:0007399;cellular process#GO:0009987 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;membrane#GO:0016020;vesicle#GO:0031982;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 HUMAN|HGNC=25528|UniProtKB=Q9NVZ3 Q9NVZ3 NECAP2 PTHR12847:SF16 ATP-BINDING CASSETTE ABC TRANSPORTER-RELATED ADAPTIN EAR-BINDING COAT-ASSOCIATED PROTEIN 2 cytoplasm#GO:0005737;vesicle coat#GO:0030120;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;membrane#GO:0016020;vesicle membrane#GO:0012506;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;clathrin-coated vesicle membrane#GO:0030665;clathrin-coated vesicle#GO:0030136;clathrin vesicle coat#GO:0030125;intracellular membrane-bounded organelle#GO:0043231;coated vesicle membrane#GO:0030662;cellular anatomical structure#GO:0110165;clathrin coat#GO:0030118;organelle#GO:0043226;vesicle#GO:0031982;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;cytoplasmic vesicle#GO:0031410;coated vesicle#GO:0030135;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane coat#GO:0030117;coated membrane#GO:0048475;intracellular organelle#GO:0043229 ATP-binding cassette (ABC) transporter#PC00003 HUMAN|HGNC=12216|UniProtKB=A0A539 A0A539 TRBV4-2 PTHR23268:SF122 T-CELL RECEPTOR BETA CHAIN T CELL RECEPTOR BETA VARIABLE 4-2 biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=24281|UniProtKB=Q8N6M0 Q8N6M0 OTUD6B PTHR12419:SF21 OTU DOMAIN CONTAINING PROTEIN DEUBIQUITINASE OTUD6B deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787;cysteine-type deubiquitinase activity#GO:0004843;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity, acting on a protein#GO:0140096 cysteine protease#PC00081 HUMAN|HGNC=21475|UniProtKB=Q6ZRQ5 Q6ZRQ5 MMS22L PTHR28547:SF1 PROTEIN MMS22-LIKE PROTEIN MMS22-LIKE cellular process#GO:0009987;response to stress#GO:0006950;replication fork processing#GO:0031297;nucleobase-containing compound metabolic process#GO:0006139;DNA recombination#GO:0006310;DNA damage response#GO:0006974;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;DNA replication#GO:0006260;double-strand break repair via homologous recombination#GO:0000724;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;recombinational repair#GO:0000725;DNA-templated DNA replication#GO:0006261 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;replication fork#GO:0005657;organelle lumen#GO:0043233;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nuclear replication fork#GO:0043596;intracellular organelle lumen#GO:0070013;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;membraneless organelle#GO:0043228 HUMAN|HGNC=33595|UniProtKB=A6NLU5 A6NLU5 VSTM2B PTHR12207:SF27 V-SET AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN V-SET AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 2B membrane#GO:0016020;cellular anatomical structure#GO:0110165 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=4055|UniProtKB=P12956 P12956 XRCC6 PTHR12604:SF5 KU AUTOANTIGEN DNA HELICASE DNA REPAIR PROTEIN KU70 binding#GO:0005488;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;sequence-specific DNA binding#GO:0043565;telomeric repeat DNA binding#GO:0042162;DNA binding#GO:0003677 response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;telomere organization#GO:0032200;cellular response to stress#GO:0033554;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;organelle organization#GO:0006996;response to stress#GO:0006950;telomere maintenance#GO:0000723;chromosome organization#GO:0051276;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;double-strand break repair via nonhomologous end joining#GO:0006303;DNA damage response#GO:0006974;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 DNA helicase#PC00011 HUMAN|HGNC=23302|UniProtKB=Q2TB90 Q2TB90 HKDC1 PTHR19443:SF28 HEXOKINASE HEXOKINASE HKDC1 hexokinase activity#GO:0004396;phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;carbohydrate kinase activity#GO:0019200;transferase activity#GO:0016740;catalytic activity#GO:0003824 pyruvate metabolic process#GO:0006090;purine-containing compound metabolic process#GO:0072521;pyridine-containing compound catabolic process#GO:0072526;purine nucleotide metabolic process#GO:0006163;monocarboxylic acid metabolic process#GO:0032787;carbohydrate catabolic process#GO:0016052;nucleotide metabolic process#GO:0009117;ribonucleotide metabolic process#GO:0009259;purine nucleoside diphosphate metabolic process#GO:0009135;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;purine nucleoside diphosphate catabolic process#GO:0009137;glucose homeostasis#GO:0042593;nucleobase-containing small molecule metabolic process#GO:0055086;ADP catabolic process#GO:0046032;carbohydrate derivative catabolic process#GO:1901136;nucleoside triphosphate metabolic process#GO:0009141;nucleoside phosphate catabolic process#GO:1901292;purine nucleoside triphosphate metabolic process#GO:0009144;primary metabolic process#GO:0044238;hexose metabolic process#GO:0019318;purine ribonucleoside diphosphate catabolic process#GO:0009181;aerobic respiration#GO:0009060;pyridine-containing compound metabolic process#GO:0072524;nucleoside diphosphate metabolic process#GO:0009132;glycolytic process#GO:0006096;purine ribonucleoside triphosphate metabolic process#GO:0009205;organophosphate metabolic process#GO:0019637;cellular homeostasis#GO:0019725;ADP metabolic process#GO:0046031;purine ribonucleoside diphosphate metabolic process#GO:0009179;generation of precursor metabolites and energy#GO:0006091;pyridine nucleotide catabolic process#GO:0019364;small molecule metabolic process#GO:0044281;ribonucleoside diphosphate metabolic process#GO:0009185;carbohydrate homeostasis#GO:0033500;phosphorus metabolic process#GO:0006793;carboxylic acid metabolic process#GO:0019752;intracellular glucose homeostasis#GO:0001678;oxoacid metabolic process#GO:0043436;ATP metabolic process#GO:0046034;nicotinamide nucleotide metabolic process#GO:0046496;glucose metabolic process#GO:0006006;purine-containing compound catabolic process#GO:0072523;chemical homeostasis#GO:0048878;purine ribonucleotide metabolic process#GO:0009150;monosaccharide metabolic process#GO:0005996;metabolic process#GO:0008152;nucleoside phosphate metabolic process#GO:0006753;carbohydrate metabolic process#GO:0005975;homeostatic process#GO:0042592;glucose 6-phosphate metabolic process#GO:0051156;catabolic process#GO:0009056;nucleoside diphosphate catabolic process#GO:0009134;purine ribonucleotide catabolic process#GO:0009154;cellular respiration#GO:0045333;organophosphate catabolic process#GO:0046434;ribonucleoside diphosphate catabolic process#GO:0009191;purine nucleotide catabolic process#GO:0006195;nucleobase-containing compound metabolic process#GO:0006139;ribonucleotide catabolic process#GO:0009261;carbohydrate derivative metabolic process#GO:1901135;nucleobase-containing compound catabolic process#GO:0034655;intracellular chemical homeostasis#GO:0055082;energy derivation by oxidation of organic compounds#GO:0015980;nucleotide catabolic process#GO:0009166 cytoplasmic side of membrane#GO:0098562;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;mitochondrial outer membrane#GO:0005741;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;cytosol#GO:0005829;membrane#GO:0016020;cytoplasm#GO:0005737;organelle outer membrane#GO:0031968;intracellular organelle#GO:0043229;outer membrane#GO:0019867;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;side of membrane#GO:0098552;mitochondrion#GO:0005739;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 kinase#PC00137;metabolite interconversion enzyme#PC00262;transferase#PC00220 Glycolysis#P00024>Hexokinase#P00677;Fructose galactose metabolism#P02744>Hexokinase#P02966;Pentose phosphate pathway#P02762>Hexokinase#P03079 HUMAN|HGNC=5407|UniProtKB=P09914 P09914 IFIT1 PTHR10271:SF34 INTERFERON-INDUCED PROTEIN WITH TETRATRICOPEPTIDE REPEATS ANTIVIRAL INNATE IMMUNE RESPONSE EFFECTOR IFIT1 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 response to stimulus#GO:0050896;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;defense response to virus#GO:0051607;cellular response to cytokine stimulus#GO:0071345;antiviral innate immune response#GO:0140374;response to virus#GO:0009615;response to peptide#GO:1901652;immune system process#GO:0002376;response to chemical#GO:0042221;response to cytokine#GO:0034097;defense response to other organism#GO:0098542;response to other organism#GO:0051707;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;immune response#GO:0006955;defense response to symbiont#GO:0140546;innate immune response#GO:0045087;response to external stimulus#GO:0009605;defense response#GO:0006952 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 defense/immunity protein#PC00090 HUMAN|HGNC=14083|UniProtKB=Q96JP2 Q96JP2 MYO15B PTHR22692:SF16 MYOSIN VII, XV UNCONVENTIONAL MYOSIN-XVB actin binding motor protein#PC00040 HUMAN|HGNC=18067|UniProtKB=Q8TD20 Q8TD20 SLC2A12 PTHR48023:SF2 D-XYLOSE-PROTON SYMPORTER-LIKE 2 SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 12 sugar transmembrane transporter activity#GO:0051119;carbohydrate transmembrane transporter activity#GO:0015144;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 D-glucose transmembrane transport#GO:1904659;cellular process#GO:0009987;circulatory system development#GO:0072359;multicellular organismal process#GO:0032501;carbohydrate transmembrane transport#GO:0034219;carbohydrate transport#GO:0008643;developmental process#GO:0032502;transport#GO:0006810;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;localization#GO:0051179;multicellular organism development#GO:0007275;establishment of localization#GO:0051234;anatomical structure development#GO:0048856;transmembrane transport#GO:0055085 cellular anatomical structure#GO:0110165;membrane#GO:0016020 primary active transporter#PC00068;transporter#PC00227 HUMAN|HGNC=25707|UniProtKB=Q5SQS8 Q5SQS8 C10orf120 PTHR47509:SF1 MCG1612 SIMILAR TO HUMAN CHROMOSOME 10 OPEN READING FRAME 120 HUMAN|HGNC=15017|UniProtKB=Q6IEZ7 Q6IEZ7 OR2T5 PTHR26453:SF161 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2T29-RELATED molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 nervous system process#GO:0050877;sensory perception#GO:0007600;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;detection of chemical stimulus#GO:0009593;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;response to stimulus#GO:0050896;response to chemical#GO:0042221 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=26955|UniProtKB=Q9UFB7 Q9UFB7 ZBTB47 PTHR24394:SF24 ZINC FINGER PROTEIN ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 47 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700 regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HUMAN|HGNC=29615|UniProtKB=Q86SG7 Q86SG7 LYG2 PTHR31698:SF4 LYSOZYME G FAMILY MEMBER LYSOZYME G-LIKE PROTEIN 2 hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;lysozyme activity#GO:0003796;catalytic activity#GO:0003824;peptidoglycan muralytic activity#GO:0061783;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553 response to bacterium#GO:0009617;defense response to bacterium#GO:0042742;response to external stimulus#GO:0009605;defense response#GO:0006952;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;defense response to Gram-positive bacterium#GO:0050830;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to other organism#GO:0051707 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=1678|UniProtKB=P01730 P01730 CD4 PTHR11422:SF0 T-CELL SURFACE GLYCOPROTEIN CD4 T-CELL SURFACE GLYCOPROTEIN CD4 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=22224|UniProtKB=Q6ZMT4 Q6ZMT4 KDM7A PTHR23123:SF15 PHD/F-BOX CONTAINING PROTEIN LYSINE-SPECIFIC DEMETHYLASE 7A demethylase activity#GO:0032451;catalytic activity, acting on a protein#GO:0140096;protein demethylase activity#GO:0140457;histone modifying activity#GO:0140993;catalytic activity#GO:0003824;histone demethylase activity#GO:0032452 cellular process#GO:0009987;cellular component organization#GO:0016043;chromatin organization#GO:0006325;chromatin remodeling#GO:0006338;cellular component organization or biogenesis#GO:0071840 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 histone modifying enzyme#PC00261;chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=16163|UniProtKB=Q8IUA0 Q8IUA0 WFDC8 PTHR47769:SF1 WAP FOUR-DISULFIDE CORE DOMAIN PROTEIN 8 WAP FOUR-DISULFIDE CORE DOMAIN PROTEIN 8 HUMAN|HGNC=20807|UniProtKB=Q96H40 Q96H40 ZNF486 PTHR24384:SF95 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED ZINC FINGER PROTEIN 486 DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 HUMAN|HGNC=28624|UniProtKB=Q8N1E6 Q8N1E6 FBXL14 PTHR13318:SF273 PARTNER OF PAIRED, ISOFORM B-RELATED F-BOX_LRR-REPEAT PROTEIN 14 ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;metabolic process#GO:0008152;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238 cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535;SCF ubiquitin ligase complex#GO:0019005;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;transferase complex#GO:1990234 HUMAN|HGNC=30418|UniProtKB=Q5HYK7 Q5HYK7 SH3D19 PTHR14167:SF48 SH3 DOMAIN-CONTAINING SH3 DOMAIN-CONTAINING PROTEIN 19 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 scaffold/adaptor protein#PC00226 HUMAN|HGNC=9378|UniProtKB=Q9Y478 Q9Y478 PRKAB1 PTHR10343:SF96 5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1 protein binding#GO:0005515;binding#GO:0005488;kinase binding#GO:0019900;protein kinase binding#GO:0019901;enzyme binding#GO:0019899 cell communication#GO:0007154;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;protein kinase complex#GO:1902911;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 protein-binding activity modulator#PC00095;kinase modulator#PC00140 Gonadotropin-releasing hormone receptor pathway#P06664>AMPK#P06830;p53 pathway by glucose deprivation#P04397>AMPK#P04639 HUMAN|HGNC=26203|UniProtKB=Q6UXY1 Q6UXY1 BAIAP2L2 PTHR14206:SF5 BRAIN-SPECIFIC ANGIOGENESIS INHIBITOR 1-ASSOCIATED PROTEIN 2 BAR_IMD DOMAIN-CONTAINING ADAPTER PROTEIN 2-LIKE 2 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 positive regulation of biological process#GO:0048518;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;regulation of actin cytoskeleton organization#GO:0032956;cellular component assembly#GO:0022607;positive regulation of cellular component biogenesis#GO:0044089;regulation of anatomical structure size#GO:0090066;cellular component organization or biogenesis#GO:0071840;regulation of biological process#GO:0050789;regulation of cellular component size#GO:0032535;actin filament bundle organization#GO:0061572;regulation of organelle organization#GO:0033043;regulation of protein-containing complex assembly#GO:0043254;cellular component organization#GO:0016043;regulation of cellular component biogenesis#GO:0044087;regulation of cellular component organization#GO:0051128;positive regulation of cellular component organization#GO:0051130;regulation of actin filament length#GO:0030832;regulation of biological quality#GO:0065008;positive regulation of organelle organization#GO:0010638;positive regulation of cellular process#GO:0048522;regulation of actin filament organization#GO:0110053;biological regulation#GO:0065007;regulation of actin polymerization or depolymerization#GO:0008064;regulation of actin filament polymerization#GO:0030833;positive regulation of protein polymerization#GO:0032273;regulation of actin filament-based process#GO:0032970;actin filament organization#GO:0007015;actin filament bundle assembly#GO:0051017;regulation of supramolecular fiber organization#GO:1902903;regulation of protein polymerization#GO:0032271;regulation of cytoskeleton organization#GO:0051493;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;actin filament-based process#GO:0030029;supramolecular fiber organization#GO:0097435 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=15563|UniProtKB=Q9NZH6 Q9NZH6 IL37 PTHR10078:SF31 INTERLEUKIN-1 FAMILY MEMBER INTERLEUKIN-37 receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;cytokine activity#GO:0005125;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772 cellular process#GO:0009987;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;cellular response to lipopolysaccharide#GO:0071222;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;response to lipid#GO:0033993;cellular response to lipid#GO:0071396;response to cytokine#GO:0034097;response to chemical#GO:0042221;cell surface receptor signaling pathway#GO:0007166;response to lipopolysaccharide#GO:0032496;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;response to molecule of bacterial origin#GO:0002237;biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052;response to stimulus#GO:0050896;response to oxygen-containing compound#GO:1901700;immune system process#GO:0002376;cellular response to chemical stimulus#GO:0070887;response to peptide#GO:1901652;immune response#GO:0006955;response to other organism#GO:0051707;biological regulation#GO:0065007;defense response#GO:0006952;response to external stimulus#GO:0009605;cellular response to molecule of bacterial origin#GO:0071219;cellular response to stimulus#GO:0051716;cellular response to biotic stimulus#GO:0071216;response to external biotic stimulus#GO:0043207;regulation of cellular process#GO:0050794;inflammatory response#GO:0006954;cytokine-mediated signaling pathway#GO:0019221;response to bacterium#GO:0009617;cell communication#GO:0007154 nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;extracellular region#GO:0005576;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 intercellular signal molecule#PC00207;cytokine#PC00083;interleukin superfamily#PC00128 HUMAN|HGNC=16657|UniProtKB=Q9BZR8 Q9BZR8 BCL2L14 PTHR14965:SF1 SI:CH73-248E21.1 APOPTOSIS FACILITATOR BCL-2-LIKE PROTEIN 14 regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;positive regulation of programmed cell death#GO:0043068;regulation of cell communication#GO:0010646;positive regulation of apoptotic signaling pathway#GO:2001235;regulation of programmed cell death#GO:0043067;positive regulation of signal transduction#GO:0009967;regulation of extrinsic apoptotic signaling pathway#GO:2001236;regulation of biological process#GO:0050789;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;regulation of apoptotic signaling pathway#GO:2001233;positive regulation of response to stimulus#GO:0048584;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of apoptotic process#GO:0043065;positive regulation of extrinsic apoptotic signaling pathway#GO:2001238;regulation of apoptotic process#GO:0042981;regulation of response to stimulus#GO:0048583 HUMAN|HGNC=23427|UniProtKB=Q8N8K9 Q8N8K9 KIAA1958 PTHR46963:SF1 SIMILAR TO RIKEN CDNA E130308A19 KIAA1958 HOMOLOG HUMAN|HGNC=9126|UniProtKB=O75420 O75420 GIGYF1 PTHR14445:SF37 GRB10 INTERACTING GYF PROTEIN GRB10-INTERACTING GYF PROTEIN 1 translation regulator activity#GO:0045182 negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of protein metabolic process#GO:0051246;signal transduction#GO:0007165;cellular process#GO:0009987;cell surface receptor signaling pathway#GO:0007166;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;insulin-like growth factor receptor signaling pathway#GO:0048009;negative regulation of metabolic process#GO:0009892;signaling#GO:0023052;negative regulation of translation#GO:0017148;regulation of translational initiation#GO:0006446;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;cellular response to stimulus#GO:0051716;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of protein metabolic process#GO:0051248;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=18305|UniProtKB=O75787 O75787 ATP6AP2 PTHR13351:SF5 RENIN RECEPTOR RENIN RECEPTOR regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789;positive regulation of cellular process#GO:0048522;positive regulation of signal transduction#GO:0009967;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111;positive regulation of response to stimulus#GO:0048584;positive regulation of Wnt signaling pathway#GO:0030177;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell surface#GO:0009986;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=20320|UniProtKB=Q8WXF1 Q8WXF1 PSPC1 PTHR23189:SF14 RNA RECOGNITION MOTIF-CONTAINING PARASPECKLE COMPONENT 1 nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219 RNA metabolism protein#PC00031 HUMAN|HGNC=4708|UniProtKB=P12544 P12544 GZMA PTHR24271:SF69 KALLIKREIN-RELATED GRANZYME A catalytic activity#GO:0003824;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171 signal transduction#GO:0007165;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;biosynthetic process#GO:0009058;biological regulation#GO:0065007;protein maturation#GO:0051604;gene expression#GO:0010467;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;regulation of biological process#GO:0050789;cell death#GO:0008219;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;programmed cell death#GO:0012501;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell communication#GO:0007154;protein metabolic process#GO:0019538 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 serine protease#PC00203 HUMAN|HGNC=10347|UniProtKB=P61927 P61927 RPL37 PTHR10768:SF22 60S RIBOSOMAL PROTEIN L37 LARGE RIBOSOMAL SUBUNIT PROTEIN EL37 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;ribosomal large subunit biogenesis#GO:0042273;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA biosynthetic process#GO:0032774;maturation of 5.8S rRNA#GO:0000460;ribonucleoprotein complex biogenesis#GO:0022613;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;gene expression#GO:0010467;maturation of LSU-rRNA#GO:0000470;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;cellular component biogenesis#GO:0044085;endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000479;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;ribosome#GO:0005840;cytosol#GO:0005829;cytosolic large ribosomal subunit#GO:0022625;cytosolic ribosome#GO:0022626;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 ribosomal protein#PC00202 HUMAN|HGNC=25842|UniProtKB=Q6UWX4 Q6UWX4 HHIPL2 PTHR19328:SF54 HEDGEHOG-INTERACTING PROTEIN HHIP-LIKE PROTEIN 2 protein-binding activity modulator#PC00095 HUMAN|HGNC=7864|UniProtKB=O43402 O43402 EMC8 PTHR12941:SF13 ER MEMBRANE PROTEIN COMPLEX ER MEMBRANE PROTEIN COMPLEX SUBUNIT 8 molecular carrier activity#GO:0140104;protein carrier activity#GO:0140597;membrane insertase activity#GO:0032977 cellular component organization#GO:0016043;protein insertion into ER membrane#GO:0045048;endoplasmic reticulum organization#GO:0007029;protein localization to organelle#GO:0033365;localization within membrane#GO:0051668;cellular localization#GO:0051641;localization#GO:0051179;macromolecule localization#GO:0033036;establishment of protein localization to membrane#GO:0090150;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of protein localization#GO:0045184;tail-anchored membrane protein insertion into ER membrane#GO:0071816;protein insertion into membrane#GO:0051205;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;intracellular protein localization#GO:0008104 organelle membrane#GO:0031090;endoplasmic reticulum protein-containing complex#GO:0140534;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;EMC complex#GO:0072546;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796 HUMAN|HGNC=23192|UniProtKB=Q9H5L6 Q9H5L6 THAP9 PTHR10725:SF82 THAP DOMAIN-CONTAINING PROTEIN 9 DNA TRANSPOSASE THAP9 nucleic acid binding#GO:0003676;catalytic activity#GO:0003824;binding#GO:0005488;catalytic activity, acting on a nucleic acid#GO:0140640;DNA binding#GO:0003677;catalytic activity, acting on DNA#GO:0140097 nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;macromolecule metabolic process#GO:0043170;DNA recombination#GO:0006310;metabolic process#GO:0008152;DNA metabolic process#GO:0006259 HUMAN|HGNC=20224|UniProtKB=Q96JK2 Q96JK2 DCAF5 PTHR15574:SF43 WD REPEAT DOMAIN-CONTAINING FAMILY DDB1- AND CUL4-ASSOCIATED FACTOR 5 regulation of lipid metabolic process#GO:0019216;negative regulation of cellular process#GO:0048523;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;negative regulation of biological process#GO:0048519;regulation of primary metabolic process#GO:0080090;negative regulation of metabolic process#GO:0009892;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of lipid biosynthetic process#GO:0046890 ubiquitin ligase complex#GO:0000151;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;Cul4-RING E3 ubiquitin ligase complex#GO:0080008;transferase complex#GO:1990234;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;cullin-RING ubiquitin ligase complex#GO:0031461 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=18823|UniProtKB=Q9P0T7 Q9P0T7 TMEM9 PTHR13064:SF1 TRANSMEMBRANE PROTEIN 9 FAMILY MEMBER PROTON-TRANSPORTING V-TYPE ATPASE COMPLEX ASSEMBLY REGULATOR TMEM9 HUMAN|HGNC=15763|UniProtKB=Q9H1D9 Q9H1D9 POLR3F PTHR12780:SF1 RNA POLYMERASE III DNA DIRECTED , 39KD SUBUNIT-RELATED DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC6 catalytic complex#GO:1902494;intracellular organelle#GO:0043229;RNA polymerase III complex#GO:0005666;transferase complex, transferring phosphorus-containing groups#GO:0061695;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991 DNA metabolism protein#PC00009 HUMAN|HGNC=9228|UniProtKB=O14494 O14494 PLPP1 PTHR10165:SF26 LIPID PHOSPHATE PHOSPHATASE PHOSPHOLIPID PHOSPHATASE 1 hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 phospholipid dephosphorylation#GO:0046839;regulation of biological process#GO:0050789;phosphate-containing compound metabolic process#GO:0006796;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;phospholipid metabolic process#GO:0006644;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell communication#GO:0007154;dephosphorylation#GO:0016311;signal transduction#GO:0007165;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;biological regulation#GO:0065007;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;lipid modification#GO:0030258 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 hydrolase#PC00121;phosphatase#PC00181 HUMAN|HGNC=29318|UniProtKB=Q9HCJ0 Q9HCJ0 TNRC6C PTHR13020:SF9 TRINUCLEOTIDE REPEAT-CONTAINING GENE 6 TRINUCLEOTIDE REPEAT-CONTAINING GENE 6C PROTEIN regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of catabolic process#GO:0009896;regulatory ncRNA-mediated gene silencing#GO:0031047;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;post-transcriptional gene silencing#GO:0016441;regulatory ncRNA-mediated post-transcriptional gene silencing#GO:0035194;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of mRNA catabolic process#GO:0061014;regulation of mRNA metabolic process#GO:1903311;positive regulation of mRNA metabolic process#GO:1903313;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;negative regulation of macromolecule biosynthetic process#GO:0010558;positive regulation of metabolic process#GO:0009893;negative regulation of metabolic process#GO:0009892;miRNA-mediated post-transcriptional gene silencing#GO:0035195;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013 cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;organelle#GO:0043226;intracellular organelle#GO:0043229;P-body#GO:0000932;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 RNA metabolism protein#PC00031 HUMAN|HGNC=6257|UniProtKB=Q14654 Q14654 KCNJ11 PTHR11767:SF44 INWARD RECTIFIER POTASSIUM CHANNEL ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 11 transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;monoatomic cation channel activity#GO:0005261;ligand-gated monoatomic ion channel activity#GO:0015276;potassium channel activity#GO:0005267;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079 cellular process#GO:0009987;potassium ion transport#GO:0006813;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;potassium ion import across plasma membrane#GO:1990573;establishment of localization#GO:0051234;import into cell#GO:0098657;inorganic cation import across plasma membrane#GO:0098659;import across plasma membrane#GO:0098739;metal ion transport#GO:0030001;inorganic ion import across plasma membrane#GO:0099587;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 ion channel#PC00133 HUMAN|HGNC=24700|UniProtKB=Q5QNW6 Q5QNW6 H2BC18 PTHR23428:SF364 HISTONE H2B HISTONE H2B TYPE 2-F humoral immune response#GO:0006959;antimicrobial humoral response#GO:0019730;response to external stimulus#GO:0009605;defense response#GO:0006952;antibacterial humoral response#GO:0019731;innate immune response#GO:0045087;defense response to symbiont#GO:0140546;immune response#GO:0006955;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;response to other organism#GO:0051707;defense response to other organism#GO:0098542;defense response to bacterium#GO:0042742;response to bacterium#GO:0009617;immune system process#GO:0002376;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to stimulus#GO:0050896 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=28005|UniProtKB=Q2VPK5 Q2VPK5 CTU2 PTHR20882:SF14 CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2 CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2 sulfurtransferase activity#GO:0016783;transferase activity, transferring sulphur-containing groups#GO:0016782;transferase activity#GO:0016740;catalytic activity#GO:0003824 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;tRNA wobble position uridine thiolation#GO:0002143;tRNA wobble uridine modification#GO:0002098;tRNA wobble base modification#GO:0002097;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;tRNA modification#GO:0006400;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;RNA metabolic process#GO:0016070;tRNA thio-modification#GO:0034227;macromolecule modification#GO:0043412 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 RNA processing factor#PC00147 HUMAN|HGNC=10639|UniProtKB=O43927 O43927 CXCL13 PTHR12015:SF204 SMALL INDUCIBLE CYTOKINE A C-X-C MOTIF CHEMOKINE 13 cytokine#PC00083 HUMAN|HGNC=7997|UniProtKB=Q02297 Q02297 NRG1 PTHR11100:SF7 HEREGULIN-NEUREGULIN FAMILY MEMBER PRO-NEUREGULIN-1, MEMBRANE-BOUND ISOFORM protein kinase activator activity#GO:0030295;enzyme activator activity#GO:0008047;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;protein kinase regulator activity#GO:0019887;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;kinase regulator activity#GO:0019207;binding#GO:0005488;signaling receptor binding#GO:0005102;kinase activator activity#GO:0019209;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;protein binding#GO:0005515 multicellular organismal process#GO:0032501;brain development#GO:0007420;nervous system development#GO:0007399;head development#GO:0060322;biological regulation#GO:0065007;cellular process#GO:0009987;ERBB signaling pathway#GO:0038127;signal transduction#GO:0007165;cellular developmental process#GO:0048869;animal organ development#GO:0048513;multicellular organism development#GO:0007275;cell surface receptor signaling pathway#GO:0007166;developmental process#GO:0032502;regulation of cellular process#GO:0050794;central nervous system development#GO:0007417;response to stimulus#GO:0050896;cell differentiation#GO:0030154;signaling#GO:0023052;peripheral nervous system development#GO:0007422;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207;growth factor#PC00112 EGF receptor signaling pathway#P00018>EGF#P00549 HUMAN|HGNC=8176|UniProtKB=Q9GZK7 Q9GZK7 OR11A1 PTHR24242:SF378 G-PROTEIN COUPLED RECEPTOR OLFACTORY RECEPTOR 11A1 G-protein coupled receptor#PC00021 HUMAN|HGNC=13159|UniProtKB=P51523 P51523 ZNF84 PTHR24377:SF1028 IP01015P-RELATED ZINC FINGER PROTEIN 84 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=24754|UniProtKB=P86496 P86496 PRR20A PTHR38819:SF1 PROLINE-RICH PROTEIN 20A-RELATED PROLINE-RICH PROTEIN 20A-RELATED HUMAN|HGNC=8165|UniProtKB=Q96KK4 Q96KK4 OR10C1 PTHR26453:SF669 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 10C1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;nervous system process#GO:0050877;sensory perception#GO:0007600;system process#GO:0003008;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;detection of chemical stimulus#GO:0009593;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;response to chemical#GO:0042221;response to stimulus#GO:0050896 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=29940|UniProtKB=Q9UHL3 Q9UHL3 FAM153A PTHR40712:SF2 FAMILY WITH SEQUENCE SIMILARITY 153 MEMBER C-RELATED FAMILY WITH SEQUENCE SIMILARITY 153 MEMBER C, PSEUDOGENE-RELATED HUMAN|HGNC=24658|UniProtKB=Q9BRR8 Q9BRR8 GPATCH1 PTHR13384:SF19 G PATCH DOMAIN-CONTAINING PROTEIN 1 G PATCH DOMAIN-CONTAINING PROTEIN 1 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=27050|UniProtKB=Q7Z5W3 Q7Z5W3 BCDIN3D PTHR12315:SF1 BICOID-INTERACTING PROTEIN RELATED RNA 5'-MONOPHOSPHATE METHYLTRANSFERASE RNA methyltransferase activity#GO:0008173;catalytic activity, acting on RNA#GO:0140098;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity#GO:0016740;catalytic activity#GO:0003824;methyltransferase activity#GO:0008168;O-methyltransferase activity#GO:0008171 negative regulation of cellular process#GO:0048523;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;negative regulation of metabolic process#GO:0009892;regulation of macromolecule metabolic process#GO:0060255;regulation of gene silencing by regulatory ncRNA#GO:0060966;regulation of cellular process#GO:0050794 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=13936|UniProtKB=O95867 O95867 LY6G6C PTHR32149:SF2 LYMPHOCYTE ANTIGEN 6 COMPLEX LOCUS PROTEIN G6C LYMPHOCYTE ANTIGEN 6 COMPLEX LOCUS PROTEIN G6C HUMAN|HGNC=24670|UniProtKB=Q53EP0 Q53EP0 FNDC3B PTHR24099:SF19 E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN 3B ubiquitin-protein ligase#PC00234 HUMAN|HGNC=24236|UniProtKB=Q8IX12 Q8IX12 CCAR1 PTHR14304:SF14 CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN 1 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=4830|UniProtKB=P02100 P02100 HBE1 PTHR11442:SF103 HEMOGLOBIN FAMILY MEMBER HEMOGLOBIN SUBUNIT EPSILON protein binding#GO:0005515;tetrapyrrole binding#GO:0046906;molecular carrier activity#GO:0140104;binding#GO:0005488;heme binding#GO:0020037 cellular developmental process#GO:0048869;establishment of localization#GO:0051234;multicellular organismal-level homeostasis#GO:0048871;transport#GO:0006810;developmental process#GO:0032502;multicellular organismal process#GO:0032501;hemopoiesis#GO:0030097;cellular process#GO:0009987;anatomical structure development#GO:0048856;erythrocyte differentiation#GO:0030218;localization#GO:0051179;immune system process#GO:0002376;homeostasis of number of cells#GO:0048872;myeloid cell differentiation#GO:0030099;cell differentiation#GO:0030154;cell development#GO:0048468;homeostatic process#GO:0042592 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytosol#GO:0005829 transfer/carrier protein#PC00219;globin#PC00107 HUMAN|HGNC=2026|UniProtKB=P51800 P51800 CLCNKA PTHR45720:SF16 CHLORIDE CHANNEL PROTEIN 2 CHLORIDE CHANNEL PROTEIN CLC-KA voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;monoatomic anion channel activity#GO:0005253;voltage-gated channel activity#GO:0022832;channel activity#GO:0015267;chloride transmembrane transporter activity#GO:0015108;passive transmembrane transporter activity#GO:0022803;chloride channel activity#GO:0005254;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic anion transmembrane transporter activity#GO:0008509;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;voltage-gated monoatomic anion channel activity#GO:0008308 inorganic anion transport#GO:0015698;monoatomic ion transport#GO:0006811;localization#GO:0051179;establishment of localization#GO:0051234;transport#GO:0006810;monoatomic anion transport#GO:0006820;chloride transport#GO:0006821 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=15802|UniProtKB=Q9BWX5 Q9BWX5 GATA5 PTHR10071:SF289 TRANSCRIPTION FACTOR GATA FAMILY MEMBER TRANSCRIPTION FACTOR GATA-5 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;circulatory system development#GO:0072359;negative regulation of metabolic process#GO:0009892;animal gross anatomical part developmental process#GO:0160108;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;negative regulation of DNA-templated transcription#GO:0045892;cell fate commitment#GO:0045165;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of macromolecule biosynthetic process#GO:0010558;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;heart development#GO:0007507;positive regulation of transcription by RNA polymerase II#GO:0045944;striated muscle tissue development#GO:0014706;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;multicellular organism development#GO:0007275;animal organ development#GO:0048513;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biosynthetic process#GO:0009891;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;muscle tissue development#GO:0060537;system development#GO:0048731;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;multicellular organismal process#GO:0032501;tissue development#GO:0009888;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;cardiac muscle tissue development#GO:0048738;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 DNA-binding transcription factor#PC00218 HUMAN|HGNC=26144|UniProtKB=Q86YC2 Q86YC2 PALB2 PTHR14662:SF2 PARTNER AND LOCALIZER OF BRCA2 PARTNER AND LOCALIZER OF BRCA2 nucleic acid binding#GO:0003676;binding#GO:0005488;DNA binding#GO:0003677 cellular response to stress#GO:0033554;recombinational repair#GO:0000725;response to stimulus#GO:0050896;double-strand break repair via homologous recombination#GO:0000724;cellular response to stimulus#GO:0051716;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;DNA recombination#GO:0006310;DNA damage response#GO:0006974;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;response to stress#GO:0006950 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 HUMAN|HGNC=16758|UniProtKB=Q9UBW8 Q9UBW8 COPS7A PTHR15350:SF7 COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17 COP9 SIGNALOSOME COMPLEX SUBUNIT 7A macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152;post-translational protein modification#GO:0043687;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein modification process#GO:0036211 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;COP9 signalosome#GO:0008180 HUMAN|HGNC=23686|UniProtKB=Q5QP82 Q5QP82 DCAF10 PTHR14588:SF2 DDB1- AND CUL4-ASSOCIATED FACTOR 10 DDB1- AND CUL4-ASSOCIATED FACTOR 10 Cul4-RING E3 ubiquitin ligase complex#GO:0080008;catalytic complex#GO:1902494;transferase complex#GO:1990234;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461 HUMAN|HGNC=28111|UniProtKB=Q8IZ81 Q8IZ81 ELMOD2 PTHR12771:SF47 ENGULFMENT AND CELL MOTILITY ELMO DOMAIN-CONTAINING PROTEIN 2 molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;enzyme activator activity#GO:0008047 cilium organization#GO:0044782;regulation of defense response#GO:0031347;organelle assembly#GO:0070925;regulation of response to biotic stimulus#GO:0002831;cell projection organization#GO:0030030;regulation of biological process#GO:0050789;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cellular component organization or biogenesis#GO:0071840;regulation of response to stimulus#GO:0048583;regulation of response to stress#GO:0080134;plasma membrane bounded cell projection assembly#GO:0120031;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;regulation of response to external stimulus#GO:0032101;cellular component assembly#GO:0022607;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cilium#GO:0005929 scaffold/adaptor protein#PC00226 HUMAN|HGNC=30655|UniProtKB=Q8N0Z2 Q8N0Z2 ABRA PTHR22739:SF20 STRIATED MUSCLE ACTIVATOR OF RHO-DEPENDENT SIGNALING-RELATED ACTIN-BINDING RHO-ACTIVATING PROTEIN regulation of RNA biosynthetic process#GO:2001141;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;positive regulation of response to stimulus#GO:0048584;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;positive regulation of RNA metabolic process#GO:0051254;regulation of cell communication#GO:0010646;regulation of macromolecule metabolic process#GO:0060255;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;positive regulation of signal transduction#GO:0009967;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;regulation of small GTPase mediated signal transduction#GO:0051056;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of transcription by RNA polymerase II#GO:0006357;regulation of Rho protein signal transduction#GO:0035023;regulation of biological process#GO:0050789;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531 intracellular organelle#GO:0043229;sarcomere#GO:0030017;membraneless organelle#GO:0043228;myofibril#GO:0030016;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;contractile muscle fiber#GO:0043292;organelle#GO:0043226;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737 HUMAN|HGNC=30282|UniProtKB=Q3MIN7 Q3MIN7 RGL3 PTHR23113:SF220 GUANINE NUCLEOTIDE EXCHANGE FACTOR RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE 3 molecular function regulator activity#GO:0098772;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;guanyl-nucleotide exchange factor activity#GO:0005085 Ras protein signal transduction#GO:0007265;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;intracellular signaling cassette#GO:0141124;small GTPase-mediated signal transduction#GO:0007264;signaling#GO:0023052;biological regulation#GO:0065007 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=23186|UniProtKB=Q14677 Q14677 CLINT1 PTHR12276:SF126 EPSIN/ENT-RELATED CLATHRIN INTERACTOR 1 lipid binding#GO:0008289;protein binding#GO:0005515;phospholipid binding#GO:0005543;binding#GO:0005488;clathrin binding#GO:0030276 cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;protein-containing complex organization#GO:0043933;cellular component assembly#GO:0022607;cellular component organization or biogenesis#GO:0071840 intracellular membrane-bounded organelle#GO:0043231;coated vesicle membrane#GO:0030662;cellular anatomical structure#GO:0110165;clathrin coat#GO:0030118;organelle#GO:0043226;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;coated vesicle#GO:0030135;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane coat#GO:0030117;coated membrane#GO:0048475;endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;plasma membrane#GO:0005886;vesicle coat#GO:0030120;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020;vesicle membrane#GO:0012506;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;clathrin-coated vesicle membrane#GO:0030665;clathrin-coated vesicle#GO:0030136;clathrin vesicle coat#GO:0030125 membrane trafficking regulatory protein#PC00151;membrane traffic protein#PC00150 HUMAN|HGNC=12140|UniProtKB=A0A0B4J268 A0A0B4J268 TRAV4 PTHR19433:SF111 T-CELL RECEPTOR ALPHA CHAIN V REGION-RELATED T CELL RECEPTOR ALPHA VARIABLE 4 response to bacterium#GO:0009617;response to biotic stimulus#GO:0009607;response to external stimulus#GO:0009605;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to other organism#GO:0051707;response to stimulus#GO:0050896 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=17098|UniProtKB=Q9UPY3 Q9UPY3 DICER1 PTHR14950:SF82 DICER-RELATED ENDORIBONUCLEASE DICER hydrolase activity#GO:0016787;RNA binding#GO:0003723;nucleic acid binding#GO:0003676;endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;DNA endonuclease activity, producing 5'-phosphomonoesters#GO:0016888;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;DNA nuclease activity#GO:0004536;hydrolase activity, acting on ester bonds#GO:0016788;DNA endonuclease activity#GO:0004520;nuclease activity#GO:0004518;binding#GO:0005488;catalytic activity, acting on DNA#GO:0140097;catalytic activity, acting on RNA#GO:0140098;RNA endonuclease activity#GO:0004521 DNA catabolic process#GO:0006308;miRNA processing#GO:0035196;nucleic acid biosynthetic process#GO:0141187;cellular component disassembly#GO:0022411;RNA metabolic process#GO:0016070;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;apoptotic process#GO:0006915;siRNA processing#GO:0030422;regulation of biological process#GO:0050789;execution phase of apoptosis#GO:0097194;negative regulation of metabolic process#GO:0009892;DNA metabolic process#GO:0006259;macromolecule catabolic process#GO:0009057;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;gene expression#GO:0010467;apoptotic DNA fragmentation#GO:0006309;RNA processing#GO:0006396;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;programmed cell death#GO:0012501;cell death#GO:0008219;regulation of cellular process#GO:0050794;pre-miRNA processing#GO:0031054;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;RNA biosynthetic process#GO:0032774;negative regulation of cellular process#GO:0048523;regulatory ncRNA-mediated gene silencing#GO:0031047;regulation of biosynthetic process#GO:0009889;regulatory ncRNA processing#GO:0070918;macromolecule metabolic process#GO:0043170;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;nucleobase-containing compound catabolic process#GO:0034655;macromolecule biosynthetic process#GO:0009059;nucleic acid catabolic process#GO:0141188;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;biosynthetic process#GO:0009058 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;endonuclease complex#GO:1905348;endoribonuclease complex#GO:1902555;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=10631|UniProtKB=Q8NHW4 Q8NHW4 CCL4L1 PTHR12015:SF103 SMALL INDUCIBLE CYTOKINE A C-C MOTIF CHEMOKINE 4-LIKE chemokine receptor binding#GO:0042379;protein binding#GO:0005515;molecular function activator activity#GO:0140677;cytokine receptor binding#GO:0005126;signaling receptor binding#GO:0005102;binding#GO:0005488;cytokine activity#GO:0005125;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;G protein-coupled receptor binding#GO:0001664;chemokine activity#GO:0008009 regulation of cellular process#GO:0050794;cell motility#GO:0048870;response to external biotic stimulus#GO:0043207;locomotion#GO:0040011;cellular response to chemokine#GO:1990869;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;regulation of cell motility#GO:2000145;chemokine-mediated signaling pathway#GO:0070098;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;cell chemotaxis#GO:0060326;cytokine-mediated signaling pathway#GO:0019221;chemotaxis#GO:0006935;inflammatory response#GO:0006954;cell migration#GO:0016477;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;response to other organism#GO:0051707;positive regulation of cellular process#GO:0048522;immune response#GO:0006955;positive regulation of cell migration#GO:0030335;positive regulation of locomotion#GO:0040017;myeloid leukocyte migration#GO:0097529;response to external stimulus#GO:0009605;leukocyte chemotaxis#GO:0030595;defense response#GO:0006952;leukocyte migration#GO:0050900;regulation of cell migration#GO:0030334;response to stimulus#GO:0050896;granulocyte chemotaxis#GO:0071621;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;positive regulation of cell motility#GO:2000147;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;response to peptide#GO:1901652;cellular response to chemical stimulus#GO:0070887;immune system process#GO:0002376;G protein-coupled receptor signaling pathway#GO:0007186;response to chemical#GO:0042221;response to cytokine#GO:0034097;taxis#GO:0042330;granulocyte migration#GO:0097530;defense response to other organism#GO:0098542;response to chemokine#GO:1990868;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;defense response to symbiont#GO:0140546;cellular process#GO:0009987;humoral immune response#GO:0006959;antimicrobial humoral response#GO:0019730;cell surface receptor signaling pathway#GO:0007166 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 cytokine#PC00083 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CHK#P00856 HUMAN|HGNC=8908|UniProtKB=Q15124 Q15124 PGM5 PTHR22573:SF27 PHOSPHOHEXOMUTASE FAMILY MEMBER PHOSPHOGLUCOMUTASE-LIKE PROTEIN 5 isomerase activity#GO:0016853;catalytic activity#GO:0003824;intramolecular transferase activity#GO:0016866;intramolecular phosphotransferase activity#GO:0016868 animal gross anatomical part developmental process#GO:0160108;striated muscle cell development#GO:0055002;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cell differentiation#GO:0030154;cell development#GO:0048468;actomyosin structure organization#GO:0031032;metabolic process#GO:0008152;cellular anatomical entity morphogenesis#GO:0032989;striated muscle tissue development#GO:0014706;cellular component organization or biogenesis#GO:0071840;striated muscle cell differentiation#GO:0051146;anatomical structure formation involved in morphogenesis#GO:0048646;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;cellular component assembly involved in morphogenesis#GO:0010927;organelle assembly#GO:0070925;actin filament-based process#GO:0030029;anatomical structure development#GO:0048856;muscle tissue development#GO:0060537;supramolecular fiber organization#GO:0097435;primary metabolic process#GO:0044238;muscle cell development#GO:0055001;myofibril assembly#GO:0030239;muscle cell differentiation#GO:0042692;actin cytoskeleton organization#GO:0030036;muscle structure development#GO:0061061;carbohydrate metabolic process#GO:0005975;developmental process#GO:0032502;cellular developmental process#GO:0048869;tissue development#GO:0009888 adherens junction#GO:0005912;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;cell junction#GO:0030054;sarcolemma#GO:0042383;cell-substrate junction#GO:0030055;plasma membrane#GO:0005886;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;cytosol#GO:0005829;membrane#GO:0016020;cell-cell junction#GO:0005911 isomerase#PC00135;metabolite interconversion enzyme#PC00262;mutase#PC00160 HUMAN|HGNC=24529|UniProtKB=Q9Y2Y6 Q9Y2Y6 TMEM98 PTHR32510:SF4 TRANSMEMBRANE PROTEIN 98 TRANSMEMBRANE PROTEIN 98 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 HUMAN|HGNC=434|UniProtKB=O15296 O15296 ALOX15B PTHR11771:SF207 LIPOXYGENASE POLYUNSATURATED FATTY ACID LIPOXYGENASE ALOX15B catalytic activity#GO:0003824;dioxygenase activity#GO:0051213;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen#GO:0016702 small molecule metabolic process#GO:0044281;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;carboxylic acid biosynthetic process#GO:0046394;arachidonate metabolic process#GO:0019369;lipid oxidation#GO:0034440;oxoacid metabolic process#GO:0043436;olefinic compound metabolic process#GO:0120254;icosanoid metabolic process#GO:0006690;lipid biosynthetic process#GO:0008610;fatty acid biosynthetic process#GO:0006633;biosynthetic process#GO:0009058;long-chain fatty acid metabolic process#GO:0001676;cellular process#GO:0009987;lipid modification#GO:0030258;monocarboxylic acid biosynthetic process#GO:0072330;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;unsaturated fatty acid metabolic process#GO:0033559;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629 oxygenase#PC00177;oxidoreductase#PC00176 HUMAN|HGNC=14370|UniProtKB=O95084 O95084 PRSS23 PTHR15462:SF10 SERINE PROTEASE SERINE PROTEASE 23 serine protease#PC00203 HUMAN|HGNC=2244|UniProtKB=Q99807 Q99807 COQ7 PTHR11237:SF6 COENZYME Q10 BIOSYNTHESIS PROTEIN 7 NADPH-DEPENDENT 3-DEMETHOXYUBIQUINONE 3-HYDROXYLASE, MITOCHONDRIAL monooxygenase activity#GO:0004497;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen#GO:0016709;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;oxidoreductase activity#GO:0016491 ketone metabolic process#GO:0042180;regulation of metabolic process#GO:0019222;ketone biosynthetic process#GO:0042181;cellular process#GO:0009987;ubiquinone biosynthetic process#GO:0006744;regulation of biological process#GO:0050789;multicellular organismal process#GO:0032501;regulation of cellular process#GO:0050794;small molecule metabolic process#GO:0044281;biological regulation#GO:0065007;biosynthetic process#GO:0009058;metabolic process#GO:0008152;small molecule biosynthetic process#GO:0044283;regulation of reactive oxygen species metabolic process#GO:2000377 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;mitochondrion#GO:0005739;organelle membrane#GO:0031090;cytoplasm#GO:0005737;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;nucleus#GO:0005634;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrial membrane#GO:0031966 HUMAN|HGNC=4812|UniProtKB=P54257 P54257 HAP1 PTHR15751:SF14 TRAFFICKING KINESIN-BINDING PROTEIN HUNTINGTIN-ASSOCIATED PROTEIN 1 myosin binding#GO:0017022;binding#GO:0005488;signaling receptor binding#GO:0005102;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515 biological regulation#GO:0065007;cytoskeleton-dependent intracellular transport#GO:0030705;multicellular organismal process#GO:0032501;vesicle localization#GO:0051648;vesicle cytoskeletal trafficking#GO:0099518;mitochondrion localization#GO:0051646;neurogenesis#GO:0022008;transport along microtubule#GO:0010970;establishment of localization#GO:0051234;cellular developmental process#GO:0048869;developmental process#GO:0032502;transport#GO:0006810;intracellular transport#GO:0046907;vesicle transport along microtubule#GO:0047496;response to growth factor#GO:0070848;microtubule-based movement#GO:0007018;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;system development#GO:0048731;localization#GO:0051179;cell communication#GO:0007154;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;organelle localization#GO:0051640;establishment of vesicle localization#GO:0051650;nervous system development#GO:0007399;organelle transport along microtubule#GO:0072384;signal transduction#GO:0007165;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;microtubule-based process#GO:0007017;multicellular organism development#GO:0007275;cell surface receptor signaling pathway#GO:0007166;signaling#GO:0023052;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;cell differentiation#GO:0030154;establishment of organelle localization#GO:0051656;protein targeting#GO:0006605;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;cellular response to growth factor stimulus#GO:0071363;cellular localization#GO:0051641;microtubule-based transport#GO:0099111;animal gross anatomical part developmental process#GO:0160108 somatodendritic compartment#GO:0036477;cytoplasm#GO:0005737;neuron projection#GO:0043005;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;dendrite#GO:0030425;intracellular organelle#GO:0043229;dendritic tree#GO:0097447;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;intracellular vesicle#GO:0097708;vesicle#GO:0031982;mitochondrion#GO:0005739 membrane traffic protein#PC00150 Huntington disease#P00029>HAP1#P00762 HUMAN|HGNC=15101|UniProtKB=Q8NH95 Q8NH95 OR13C6P PTHR26453:SF635 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 13C7-RELATED molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 system process#GO:0003008;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;nervous system process#GO:0050877;sensory perception#GO:0007600;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;response to stimulus#GO:0050896;response to chemical#GO:0042221;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;detection of chemical stimulus#GO:0009593 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=16172|UniProtKB=Q9H503 Q9H503 BANF2 PTHR47507:SF4 BARRIER TO AUTOINTEGRATION FACTOR 2 BARRIER-TO-AUTOINTEGRATION FACTOR-LIKE PROTEIN DNA binding#GO:0003677;nucleic acid binding#GO:0003676;binding#GO:0005488 chromosome organization#GO:0051276;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996 chromosome#GO:0005694;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;condensed chromosome#GO:0000793;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=23040|UniProtKB=Q5T5X7 Q5T5X7 BEND3 PTHR28665:SF1 BEN DOMAIN-CONTAINING PROTEIN 3 BEN DOMAIN-CONTAINING PROTEIN 3 DNA binding#GO:0003677;sequence-specific double-stranded DNA binding#GO:1990837;rDNA binding#GO:0000182;sequence-specific DNA binding#GO:0043565;double-stranded DNA binding#GO:0003690;binding#GO:0005488;nucleic acid binding#GO:0003676 chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;heterochromatin organization#GO:0070828;cellular component assembly#GO:0022607;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of gene expression, epigenetic#GO:0045814;cellular component organization or biogenesis#GO:0071840;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;heterochromatin formation#GO:0031507;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of DNA-templated transcription#GO:0006355;nucleolus organization#GO:0007000;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;epigenetic regulation of gene expression#GO:0040029;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;nucleus organization#GO:0006997;regulation of biosynthetic process#GO:0009889;negative regulation of cellular process#GO:0048523 winged helix/forkhead transcription factor#PC00246;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=3165|UniProtKB=P21453 P21453 S1PR1 PTHR22750:SF16 G-PROTEIN COUPLED RECEPTOR SPHINGOSINE 1-PHOSPHATE RECEPTOR 1 bioactive lipid receptor activity#GO:0045125;transmembrane signaling receptor activity#GO:0004888;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 G protein-coupled receptor signaling pathway#GO:0007186;animal gross anatomical part developmental process#GO:0160108;cell communication#GO:0007154;angiogenesis#GO:0001525;anatomical structure development#GO:0048856;system development#GO:0048731;blood vessel morphogenesis#GO:0048514;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;cellular response to stimulus#GO:0051716;blood vessel development#GO:0001568;tube morphogenesis#GO:0035239;response to stimulus#GO:0050896;circulatory system development#GO:0072359;regulation of cellular process#GO:0050794;signaling#GO:0023052;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;developmental process#GO:0032502;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;multicellular organism development#GO:0007275;anatomical structure formation involved in morphogenesis#GO:0048646;vasculature development#GO:0001944;signal transduction#GO:0007165;cellular process#GO:0009987;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;tube development#GO:0035295 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 G-protein coupled receptor#PC00021 HUMAN|HGNC=19265|UniProtKB=Q86SS6 Q86SS6 SYT9 PTHR10024:SF180 SYNAPTOTAGMIN SYNAPTOTAGMIN-9 SNARE binding#GO:0000149;phospholipid binding#GO:0005543;binding#GO:0005488;lipid binding#GO:0008289;molecular function regulator activity#GO:0098772;molecular sensor activity#GO:0140299;protein binding#GO:0005515 regulation of cellular component organization#GO:0051128;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;signaling#GO:0023052;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;regulation of organelle organization#GO:0033043;cell communication#GO:0007154;regulation of secretion#GO:0051046;localization#GO:0051179;positive regulation of organelle organization#GO:0010638;regulation of secretion by cell#GO:1903530;regulation of exocytosis#GO:0017157;trans-synaptic signaling#GO:0099537;positive regulation of cellular component organization#GO:0051130;vesicle-mediated transport#GO:0016192;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;synaptic signaling#GO:0099536;positive regulation of transport#GO:0051050;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;establishment of localization#GO:0051234;regulation of localization#GO:0032879;regulation of transport#GO:0051049;positive regulation of vesicle fusion#GO:0031340;transport#GO:0006810 transport vesicle#GO:0030133;endomembrane system#GO:0012505;plasma membrane#GO:0005886;cytoplasm#GO:0005737;secretory vesicle#GO:0099503;membrane#GO:0016020;cell periphery#GO:0071944;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382 membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=21087|UniProtKB=Q7Z6A9 Q7Z6A9 BTLA PTHR37996:SF1 B- AND T-LYMPHOCYTE ATTENUATOR B- AND T-LYMPHOCYTE ATTENUATOR signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007;cellular response to stimulus#GO:0051716;immune response-regulating signaling pathway#GO:0002764;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;regulation of response to stimulus#GO:0048583;regulation of immune response#GO:0050776 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HUMAN|HGNC=12017|UniProtKB=P12270 P12270 TPR PTHR18898:SF8 NUCLEOPROTEIN TPR-RELATED NUCLEOPROTEIN TPR structural molecule activity#GO:0005198;structural constituent of nuclear pore#GO:0017056 regulation of organelle assembly#GO:1902115;macromolecule biosynthetic process#GO:0009059;macromolecule localization#GO:0033036;nitrogen compound transport#GO:0071705;biosynthetic process#GO:0009058;biological regulation#GO:0065007;transport#GO:0006810;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;macromolecule metabolic process#GO:0043170;establishment of localization#GO:0051234;establishment of RNA localization#GO:0051236;mRNA transport#GO:0051028;regulation of cytoskeleton organization#GO:0051493;nucleobase-containing compound transport#GO:0015931;regulation of spindle organization#GO:0090224;regulation of cellular process#GO:0050794;RNA localization#GO:0006403;RNA transport#GO:0050658;nucleocytoplasmic transport#GO:0006913;regulation of microtubule-based process#GO:0032886;nuclear transport#GO:0051169;nuclear export#GO:0051168;localization#GO:0051179;nucleic acid transport#GO:0050657;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;regulation of cell cycle process#GO:0010564;regulation of microtubule cytoskeleton organization#GO:0070507;gene expression#GO:0010467;metabolic process#GO:0008152;regulation of mitotic spindle assembly#GO:1901673;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;regulation of cell cycle#GO:0051726;regulation of cellular component biogenesis#GO:0044087;regulation of cellular component organization#GO:0051128;regulation of mitotic spindle organization#GO:0060236;regulation of spindle assembly#GO:0090169;mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641 nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;nucleus#GO:0005634;organelle envelope#GO:0031967;membrane-bounded organelle#GO:0043227;nuclear pore#GO:0005643;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229 primary active transporter#PC00068 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HUMAN|HGNC=23594|UniProtKB=Q709C8 Q709C8 VPS13C PTHR16166:SF125 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13 INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13C lipid transfer activity#GO:0120013;phospholipid transfer activity#GO:0120014;transporter activity#GO:0005215;lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104 catabolic process#GO:0009056;cellular component organization#GO:0016043;localization#GO:0051179;process utilizing autophagic mechanism#GO:0061919;lipid localization#GO:0010876;lipid transport#GO:0006869;mitochondrion organization#GO:0007005;membrane organization#GO:0061024;macroautophagy#GO:0016236;macromolecule localization#GO:0033036;organelle organization#GO:0006996;autophagy#GO:0006914;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;intermembrane lipid transfer#GO:0120009;establishment of localization#GO:0051234;metabolic process#GO:0008152;transport#GO:0006810 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;organelle envelope#GO:0031967;vesicle#GO:0031982;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;outer membrane#GO:0019867;endosome#GO:0005768;endosome membrane#GO:0010008;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;organelle outer membrane#GO:0031968;cytoplasm#GO:0005737;vesicle membrane#GO:0012506;membrane#GO:0016020;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;mitochondrial outer membrane#GO:0005741;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588 membrane traffic protein#PC00150 HUMAN|HGNC=8693|UniProtKB=Q9UN66 Q9UN66 PCDHB8 PTHR24028:SF338 CADHERIN-87A PROTOCADHERIN BETA-8 cellular process#GO:0009987;cell adhesion#GO:0007155 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 cell adhesion molecule#PC00069;cadherin#PC00057 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HUMAN|HGNC=12309|UniProtKB=Q15649 Q15649 ZNHIT3 PTHR13483:SF11 BOX C_D SNORNA PROTEIN 1-RELATED ZINC FINGER HIT DOMAIN-CONTAINING PROTEIN 3 biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;cellular component assembly#GO:0022607;maturation of LSU-rRNA#GO:0000470;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;protein-containing complex organization#GO:0043933;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;protein-RNA complex organization#GO:0071826;metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;protein-containing complex assembly#GO:0065003;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;rRNA processing#GO:0006364;protein-RNA complex assembly#GO:0022618;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;ribosomal large subunit biogenesis#GO:0042273;ribosome biogenesis#GO:0042254 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229 HUMAN|HGNC=20412|UniProtKB=P35900 P35900 KRT20 PTHR23239:SF167 INTERMEDIATE FILAMENT KERATIN, TYPE I CYTOSKELETAL 20 structural molecule activity#GO:0005198 tissue morphogenesis#GO:0048729;anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;intermediate filament-based process#GO:0045103;animal gross anatomical part developmental process#GO:0160108;intermediate filament organization#GO:0045109;intermediate filament cytoskeleton organization#GO:0045104;cell differentiation#GO:0030154;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;morphogenesis of an epithelium#GO:0002009;developmental process#GO:0032502;epithelium development#GO:0060429;tissue development#GO:0009888;epithelial cell differentiation#GO:0030855;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;intermediate filament#GO:0005882;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;organelle#GO:0043226;supramolecular complex#GO:0099080 intermediate filament#PC00129 HUMAN|HGNC=10542|UniProtKB=O95248 O95248 SBF1 PTHR10807:SF43 MYOTUBULARIN-RELATED MYOTUBULARIN-RELATED PROTEIN 5 hydrolase activity#GO:0016787;enzyme regulator activity#GO:0030234;guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;phosphoric ester hydrolase activity#GO:0042578;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 phospholipid dephosphorylation#GO:0046839;phosphate-containing compound metabolic process#GO:0006796;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phospholipid metabolic process#GO:0006644;glycerolipid metabolic process#GO:0046486;glycerophospholipid metabolic process#GO:0006650;phosphatidylinositol metabolic process#GO:0046488;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;phosphatidylinositol dephosphorylation#GO:0046856;dephosphorylation#GO:0016311;lipid modification#GO:0030258 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;membrane#GO:0016020 phosphatase#PC00181 HUMAN|HGNC=3664|UniProtKB=Q7Z6J4 Q7Z6J4 FGD2 PTHR12673:SF82 FACIOGENITAL DYSPLASIA PROTEIN FYVE, RHOGEF AND PH DOMAIN-CONTAINING PROTEIN 2 molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;guanyl-nucleotide exchange factor activity#GO:0005085 cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection assembly#GO:0120031;cellular component assembly#GO:0022607;cell projection organization#GO:0030030;plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;filopodium assembly#GO:0046847;cell projection assembly#GO:0030031 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 G-protein modulator#PC00022;guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=5704|UniProtKB=P0DTE2 P0DTE2 IGHV8-51-1 PTHR23266:SF399 IMMUNOGLOBULIN HEAVY CHAIN NON-FUNCTIONAL IMMUNOGLOBULIN HEAVY VARIABLE 8-51-1-RELATED antigen binding#GO:0003823;binding#GO:0005488 immune effector process#GO:0002252;immune system process#GO:0002376;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;immune response#GO:0006955;adaptive immune response#GO:0002250;response to stimulus#GO:0050896 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=32417|UniProtKB=Q7Z3J3 Q7Z3J3 RGPD4 PTHR23138:SF168 RAN BINDING PROTEIN RANBP2-LIKE AND GRIP DOMAIN-CONTAINING PROTEIN 1-RELATED aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;SUMO transferase activity#GO:0019789;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746 protein localization to organelle#GO:0033365;protein transport#GO:0015031;nuclear export#GO:0051168;protein import into nucleus#GO:0006606;nuclear transport#GO:0051169;cellular localization#GO:0051641;localization#GO:0051179;NLS-bearing protein import into nucleus#GO:0006607;nucleocytoplasmic transport#GO:0006913;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;protein localization to nucleus#GO:0034504;import into nucleus#GO:0051170;macromolecule localization#GO:0033036;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907 intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634;organelle envelope#GO:0031967;intracellular anatomical structure#GO:0005622;nuclear pore#GO:0005643;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229 scaffold/adaptor protein#PC00226 HUMAN|HGNC=30459|UniProtKB=Q8N9I5 Q8N9I5 FADS6 PTHR19353:SF13 FATTY ACID DESATURASE 2 FATTY ACID DESATURASE 6 oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705 primary metabolic process#GO:0044238;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;membrane#GO:0016020 oxidoreductase#PC00176 HUMAN|HGNC=1949|UniProtKB=Q9H2X0 Q9H2X0 CHRD PTHR46526:SF1 CHORDIN CHORDIN binding#GO:0005488;cytokine binding#GO:0019955;protein binding#GO:0005515 negative regulation of signal transduction#GO:0009968;regulation of cellular response to growth factor stimulus#GO:0090287;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of response to stimulus#GO:0048585;regionalization#GO:0003002;multicellular organismal process#GO:0032501;regulation of BMP signaling pathway#GO:0030510;negative regulation of BMP signaling pathway#GO:0030514;multicellular organism development#GO:0007275;regulation of response to stimulus#GO:0048583;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;dorsal/ventral pattern formation#GO:0009953;negative regulation of biological process#GO:0048519;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092;negative regulation of cell communication#GO:0010648;anatomical structure development#GO:0048856;regulation of signaling#GO:0023051;pattern specification process#GO:0007389;negative regulation of signaling#GO:0023057 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 DPP signaling pathway#P06213>SOG#P06293;DPP-SCW signaling pathway#P06212>SOG#P06266;BMP/activin signaling pathway-drosophila#P06211>SOG#P06252;SCW signaling pathway#P06216>SOG#P06335 HUMAN|HGNC=15525|UniProtKB=Q6XYB7 Q6XYB7 LBX2 PTHR24336:SF10 TRANSCRIPTION FACTOR LBX TRANSCRIPTION FACTOR LBX2 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 homeodomain transcription factor#PC00119 HUMAN|HGNC=11859|UniProtKB=O14817 O14817 TSPAN4 PTHR19282:SF40 TETRASPANIN TETRASPANIN-4 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HUMAN|HGNC=10069|UniProtKB=Q9Y252 Q9Y252 RNF6 PTHR45931:SF2 SI:CH211-59O9.10 E3 UBIQUITIN-PROTEIN LIGASE RNF6 acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 cellular process#GO:0009987;positive regulation of biological process#GO:0048518;protein ubiquitination#GO:0016567;positive regulation of macromolecule metabolic process#GO:0010604;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;protein modification by small protein conjugation#GO:0032446;regulation of biological process#GO:0050789;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein modification by small protein conjugation or removal#GO:0070647;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;post-translational protein modification#GO:0043687;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of gene expression#GO:0010468;ubiquitin-dependent protein catabolic process#GO:0006511;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;modification-dependent protein catabolic process#GO:0019941;protein modification process#GO:0036211;primary metabolic process#GO:0044238;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;positive regulation of biosynthetic process#GO:0009891 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=18957|UniProtKB=Q86UL8 Q86UL8 MAGI2 PTHR10316:SF27 MEMBRANE ASSOCIATED GUANYLATE KINASE-RELATED MEMBRANE-ASSOCIATED GUANYLATE KINASE, WW AND PDZ DOMAIN-CONTAINING PROTEIN 2 signaling receptor complex adaptor activity#GO:0030159;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;signaling adaptor activity#GO:0035591 regulation of biological quality#GO:0065008;regulation of protein localization#GO:0032880;cellular localization#GO:0051641;localization#GO:0051179;cell communication#GO:0007154;localization within membrane#GO:0051668;receptor clustering#GO:0043113;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;protein localization to membrane#GO:0072657;regulation of localization#GO:0032879;intracellular protein localization#GO:0008104;biological regulation#GO:0065007;cellular process#GO:0009987;regulation of protein localization to membrane#GO:1905475;signal transduction#GO:0007165;macromolecule localization#GO:0033036 dendritic tree#GO:0097447;dendrite#GO:0030425;adherens junction#GO:0005912;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;cell junction#GO:0030054;neuron projection#GO:0043005;cell-cell junction#GO:0005911;somatodendritic compartment#GO:0036477;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;synapse#GO:0045202 HUMAN|HGNC=5350|UniProtKB=O60725 O60725 ICMT PTHR12714:SF9 PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE O-methyltransferase activity#GO:0008171;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring one-carbon groups#GO:0016741;protein methyltransferase activity#GO:0008276;catalytic activity, acting on a protein#GO:0140096 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 protein modifying enzyme#PC00260 HUMAN|HGNC=23517|UniProtKB=Q8N2H3 Q8N2H3 PYROXD2 PTHR10668:SF103 PHYTOENE DEHYDROGENASE PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 2 oxidoreductase#PC00176;dehydrogenase#PC00092 HUMAN|HGNC=37157|UniProtKB=P0CJ70 P0CJ70 MTRNR2L3 PTHR33895:SF7 HUMANIN-LIKE 4 HUMANIN-LIKE 3 molecular function inhibitor activity#GO:0140678;molecular function regulator activity#GO:0098772;signaling receptor inhibitor activity#GO:0030547;signaling receptor regulator activity#GO:0030545 regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of programmed cell death#GO:0043069;regulation of cellular process#GO:0050794;negative regulation of apoptotic process#GO:0043066;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;regulation of apoptotic process#GO:0042981 HUMAN|HGNC=11317|UniProtKB=Q04837 Q04837 SSBP1 PTHR10302:SF0 SINGLE-STRANDED DNA-BINDING PROTEIN SINGLE-STRANDED DNA-BINDING PROTEIN, MITOCHONDRIAL molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;DNA binding#GO:0003677;enzyme regulator activity#GO:0030234;single-stranded DNA binding#GO:0003697;nucleic acid binding#GO:0003676;binding#GO:0005488 macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;positive regulation of DNA replication#GO:0045740;positive regulation of metabolic process#GO:0009893;regulation of DNA replication#GO:0006275;positive regulation of organelle organization#GO:0010638;positive regulation of cellular component organization#GO:0051130;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;positive regulation of DNA metabolic process#GO:0051054;regulation of mitochondrion organization#GO:0010821;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;regulation of DNA-templated DNA replication#GO:0090329;DNA replication#GO:0006260;regulation of DNA metabolic process#GO:0051052 intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;membrane-enclosed lumen#GO:0031974;membraneless organelle#GO:0043228;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoid#GO:0009295;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;mitochondrial nucleoid#GO:0042645;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;intracellular organelle lumen#GO:0070013 DNA metabolism protein#PC00009 HUMAN|HGNC=2496|UniProtKB=Q01459 Q01459 CTBS PTHR46290:SF8 DI-N-ACETYLCHITOBIASE DI-N-ACETYLCHITOBIASE hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824;chitinase activity#GO:0004568 carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;aminoglycan catabolic process#GO:0006026;amino sugar catabolic process#GO:0046348;chitin catabolic process#GO:0006032;oligosaccharide metabolic process#GO:0009311;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;chitin metabolic process#GO:0006030;catabolic process#GO:0009056;oligosaccharide catabolic process#GO:0009313;amino sugar metabolic process#GO:0006040;carbohydrate metabolic process#GO:0005975;carbohydrate derivative catabolic process#GO:1901136;primary metabolic process#GO:0044238;carbohydrate catabolic process#GO:0016052;aminoglycan metabolic process#GO:0006022 HUMAN|HGNC=23328|UniProtKB=Q6P2D0 Q6P2D0 ZFP1 PTHR24377:SF248 IP01015P-RELATED ZINC FINGER PROTEIN 1 HOMOLOG sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=28456|UniProtKB=Q6PJG9 Q6PJG9 LRFN4 PTHR45842:SF3 SYNAPTIC ADHESION-LIKE MOLECULE SALM LEUCINE-RICH REPEAT AND FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN 4 cell-cell adhesion#GO:0098609;cellular process#GO:0009987;regulation of organelle assembly#GO:1902115;regulation of synapse assembly#GO:0051963;biological regulation#GO:0065007;cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;regulation of postsynapse organization#GO:0099175;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;cell junction organization#GO:0034330;regulation of cellular component organization#GO:0051128;regulation of cellular component biogenesis#GO:0044087;regulation of cell junction assembly#GO:1901888;regulation of synapse organization#GO:0050807;cell adhesion#GO:0007155;synapse organization#GO:0050808;regulation of synapse structure or activity#GO:0050803;regulation of biological quality#GO:0065008;synaptic membrane adhesion#GO:0099560 glutamatergic synapse#GO:0098978;neuron to neuron synapse#GO:0098984;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;cell surface#GO:0009986;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;cell junction#GO:0030054;synaptic membrane#GO:0097060;cellular anatomical structure#GO:0110165;synapse#GO:0045202;asymmetric synapse#GO:0032279;organelle#GO:0043226;postsynapse#GO:0098794;postsynaptic density membrane#GO:0098839;postsynaptic specialization membrane#GO:0099634;postsynaptic membrane#GO:0045211;postsynaptic density#GO:0014069 immunoglobulin superfamily cell adhesion molecule#PC00125;cell adhesion molecule#PC00069 HUMAN|HGNC=26046|UniProtKB=Q8TBF5 Q8TBF5 PIGX PTHR28650:SF1 PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS X PROTEIN GPI ALPHA-1,4-MANNOSYLTRANSFERASE I, STABILIZING SUBUNIT HUMAN|HGNC=12295|UniProtKB=Q99603 Q99603 TRGV9 PTHR19256:SF44 T-CELL RECEPTOR GAMMA CHAIN T CELL RECEPTOR GAMMA VARIABLE 9 side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=90|UniProtKB=P16219 P16219 ACADS PTHR43884:SF42 ACYL-COA DEHYDROGENASE SHORT-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 lipid modification#GO:0030258;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;fatty acid beta-oxidation#GO:0006635;fatty acid oxidation#GO:0019395;monocarboxylic acid catabolic process#GO:0072329;cellular process#GO:0009987;lipid catabolic process#GO:0016042;carboxylic acid catabolic process#GO:0046395;lipid oxidation#GO:0034440;short-chain fatty acid catabolic process#GO:0019626;fatty acid catabolic process#GO:0009062;oxoacid metabolic process#GO:0043436;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;small molecule catabolic process#GO:0044282;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 oxidoreductase#PC00176;dehydrogenase#PC00092 HUMAN|HGNC=7096|UniProtKB=Q9UJV3 Q9UJV3 MID2 PTHR24099:SF12 E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED E3 UBIQUITIN-PROTEIN LIGASE MID2-RELATED protein binding#GO:0005515;microtubule binding#GO:0008017;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631 macromolecule localization#GO:0033036;protein localization to cytoskeleton#GO:0044380;intracellular protein localization#GO:0008104;protein localization to microtubule cytoskeleton#GO:0072698;localization#GO:0051179;protein localization to organelle#GO:0033365 intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;organelle#GO:0043226;microtubule cytoskeleton#GO:0015630;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;microtubule#GO:0005874;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=12232|UniProtKB=A0A0A0MS04 A0A0A0MS04 TRBV6-7 PTHR23268:SF86 T-CELL RECEPTOR BETA CHAIN T CELL RECEPTOR BETA VARIABLE 6-8-RELATED cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=18301|UniProtKB=Q8TDB8 Q8TDB8 SLC2A14 PTHR23503:SF53 SOLUTE CARRIER FAMILY 2 SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 14 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;carbohydrate transmembrane transporter activity#GO:0015144;sugar transmembrane transporter activity#GO:0051119 D-glucose transmembrane transport#GO:1904659;cellular process#GO:0009987;import across plasma membrane#GO:0098739;vitamin transport#GO:0051180;carbohydrate transmembrane transport#GO:0034219;carbohydrate transport#GO:0008643;transport#GO:0006810;localization#GO:0051179;import into cell#GO:0098657;establishment of localization#GO:0051234;transmembrane transport#GO:0055085 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 secondary carrier transporter#PC00258 HUMAN|HGNC=10608|UniProtKB=P47872 P47872 SCTR PTHR45620:SF13 PDF RECEPTOR-LIKE PROTEIN-RELATED SECRETIN RECEPTOR transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;molecular transducer activity#GO:0060089 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=16513|UniProtKB=Q8TDI8 Q8TDI8 TMC1 PTHR23302:SF18 TRANSMEMBRANE CHANNEL-RELATED TRANSMEMBRANE CHANNEL-LIKE PROTEIN 1 calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;channel activity#GO:0015267;voltage-gated calcium channel activity#GO:0005245;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;passive transmembrane transporter activity#GO:0022803 detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;response to abiotic stimulus#GO:0009628;response to mechanical stimulus#GO:0009612;response to stimulus#GO:0050896;sensory perception of sound#GO:0007605;multicellular organismal process#GO:0032501;detection of mechanical stimulus#GO:0050982;sensory perception of mechanical stimulus#GO:0050954;sensory perception#GO:0007600;nervous system process#GO:0050877;system process#GO:0003008;response to external stimulus#GO:0009605 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 ion channel#PC00133 HUMAN|HGNC=11929|UniProtKB=Q9Y275 Q9Y275 TNFSF13B PTHR15151:SF2 PROTEIN EIGER TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 13B molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;cytokine activity#GO:0005125;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018 positive regulation of lymphocyte activation#GO:0051251;regulation of cell population proliferation#GO:0042127;positive regulation of lymphocyte proliferation#GO:0050671;homeostasis of number of cells#GO:0048872;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;positive regulation of B cell proliferation#GO:0030890;homeostatic process#GO:0042592;multicellular organismal-level homeostasis#GO:0048871;positive regulation of leukocyte proliferation#GO:0070665;multicellular organismal process#GO:0032501;regulation of lymphocyte proliferation#GO:0050670;biological regulation#GO:0065007;positive regulation of cell activation#GO:0050867;positive regulation of cellular process#GO:0048522;immune response#GO:0006955;immune system process#GO:0002376;response to stimulus#GO:0050896;regulation of lymphocyte activation#GO:0051249;positive regulation of cell population proliferation#GO:0008284;regulation of leukocyte activation#GO:0002694;regulation of biological process#GO:0050789;regulation of cell activation#GO:0050865;positive regulation of multicellular organismal process#GO:0051240;regulation of leukocyte proliferation#GO:0070663;positive regulation of mononuclear cell proliferation#GO:0032946;regulation of B cell proliferation#GO:0030888;positive regulation of leukocyte activation#GO:0002696;regulation of multicellular organismal process#GO:0051239;regulation of B cell activation#GO:0050864;positive regulation of immune system process#GO:0002684;regulation of mononuclear cell proliferation#GO:0032944;lymphocyte homeostasis#GO:0002260;positive regulation of biological process#GO:0048518 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HUMAN|HGNC=3978|UniProtKB=O75891 O75891 ALDH1L1 PTHR11699:SF120 ALDEHYDE DEHYDROGENASE-RELATED CYTOSOLIC 10-FORMYLTETRAHYDROFOLATE DEHYDROGENASE aldehyde dehydrogenase (NAD+) activity#GO:0004029;oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor#GO:0016620;oxidoreductase activity, acting on the aldehyde or oxo group of donors#GO:0016903;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 carboxylic acid metabolic process#GO:0019752;modified amino acid metabolic process#GO:0006575;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;pteridine-containing compound metabolic process#GO:0042558;folic acid-containing compound metabolic process#GO:0006760;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;small molecule catabolic process#GO:0044282;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;tetrahydrofolate metabolic process#GO:0046653 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;dehydrogenase#PC00092 5-Hydroxytryptamine degredation#P04372>Aldehyde Dehydrogenase#P04402 HUMAN|HGNC=10659|UniProtKB=P34741 P34741 SDC2 PTHR10915:SF6 SYNDECAN SYNDECAN-2 regulation of cellular process#GO:0050794;dendrite morphogenesis#GO:0048813;regulation of synapse structure or activity#GO:0050803;anatomical structure development#GO:0048856;system development#GO:0048731;regulation of cell junction assembly#GO:1901888;multicellular organismal process#GO:0032501;regulation of synapse assembly#GO:0051963;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;cell morphogenesis#GO:0000902;cell differentiation#GO:0030154;regulation of cellular component organization#GO:0051128;cell projection organization#GO:0030030;regulation of cellular component biogenesis#GO:0044087;cell development#GO:0048468;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;dendrite development#GO:0016358;regulation of biological quality#GO:0065008;neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;regulation of synapse organization#GO:0050807;generation of neurons#GO:0048699;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;neuron projection development#GO:0031175;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cell projection morphogenesis#GO:0048858;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182 cell surface#GO:0009986;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=25932|UniProtKB=Q08AG5 Q08AG5 ZNF844 PTHR24379:SF5 KRAB AND ZINC FINGER DOMAIN-CONTAINING ZINC FINGER PROTEIN 799-RELATED RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=3585|UniProtKB=Q9BXW9 Q9BXW9 FANCD2 PTHR32086:SF0 FANCONI ANEMIA GROUP D2 PROTEIN FANCONI ANEMIA GROUP D2 PROTEIN protein binding#GO:0005515;binding#GO:0005488;enzyme binding#GO:0019899 organelle fission#GO:0048285;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;meiosis I cell cycle process#GO:0061982;mitotic cell cycle#GO:0000278;reproductive process#GO:0022414;nucleic acid metabolic process#GO:0090304;mitotic cell cycle checkpoint signaling#GO:0007093;mitotic DNA damage checkpoint signaling#GO:0044773;meiotic chromosome segregation#GO:0045132;DNA repair#GO:0006281;negative regulation of cell cycle process#GO:0010948;DNA damage checkpoint signaling#GO:0000077;nucleobase-containing compound metabolic process#GO:0006139;interstrand cross-link repair#GO:0036297;DNA integrity checkpoint signaling#GO:0031570;mitotic DNA integrity checkpoint signaling#GO:0044774;regulation of mitotic cell cycle#GO:0007346;negative regulation of mitotic cell cycle#GO:0045930;cellular response to stress#GO:0033554;signaling#GO:0023052;meiosis I#GO:0007127;cellular component organization#GO:0016043;meiotic cell cycle process#GO:1903046;negative regulation of cell cycle#GO:0045786;double-strand break repair#GO:0006302;chromosome organization involved in meiotic cell cycle#GO:0070192;metabolic process#GO:0008152;chromosome segregation#GO:0007059;DNA recombination#GO:0006310;cell cycle checkpoint signaling#GO:0000075;homologous chromosome pairing at meiosis#GO:0007129;regulation of cell cycle process#GO:0010564;response to stress#GO:0006950;sexual reproduction#GO:0019953;regulation of cellular process#GO:0050794;homologous recombination#GO:0035825;primary metabolic process#GO:0044238;regulation of cell cycle phase transition#GO:1901987;cell cycle#GO:0007049;cellular response to stimulus#GO:0051716;reciprocal homologous recombination#GO:0140527;meiotic nuclear division#GO:0140013;macromolecule metabolic process#GO:0043170;chromosome organization#GO:0051276;mitotic cell cycle process#GO:1903047;negative regulation of cellular process#GO:0048523;DNA damage response#GO:0006974;biological regulation#GO:0065007;mitotic intra-S DNA damage checkpoint signaling#GO:0031573;nuclear division#GO:0000280;reciprocal meiotic recombination#GO:0007131;response to stimulus#GO:0050896;regulation of cell cycle#GO:0051726;nuclear chromosome segregation#GO:0098813;negative regulation of cell cycle phase transition#GO:1901988;negative regulation of biological process#GO:0048519;cell cycle process#GO:0022402;regulation of biological process#GO:0050789;signal transduction in response to DNA damage#GO:0042770;homologous chromosome segregation#GO:0045143;cellular component organization or biogenesis#GO:0071840;DNA metabolic process#GO:0006259;meiotic cell cycle#GO:0051321;organelle organization#GO:0006996;cellular process#GO:0009987;signal transduction#GO:0007165 intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;condensed chromosome#GO:0000793 HUMAN|HGNC=28316|UniProtKB=Q8TCD6 Q8TCD6 PHOSPHO2 PTHR20889:SF1 PHOSPHATASE, ORPHAN 1, 2 PYRIDOXAL PHOSPHATE PHOSPHATASE PHOSPHO2 phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578 hydrolase#PC00121;phosphatase#PC00181 HUMAN|HGNC=13818|UniProtKB=Q9H2X9 Q9H2X9 SLC12A5 PTHR11827:SF54 SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS SOLUTE CARRIER FAMILY 12 MEMBER 5 monoatomic cation transmembrane transporter activity#GO:0008324;potassium ion transmembrane transporter activity#GO:0015079;symporter activity#GO:0015293;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;secondary active transmembrane transporter activity#GO:0015291;monoatomic anion transmembrane transporter activity#GO:0008509;chloride transmembrane transporter activity#GO:0015108 monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;inorganic anion transport#GO:0015698;monoatomic ion transport#GO:0006811;chloride transport#GO:0006821;transport#GO:0006810;potassium ion transport#GO:0006813;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;potassium ion transmembrane transport#GO:0071805;monoatomic ion transmembrane transport#GO:0034220;monoatomic anion transport#GO:0006820;cellular process#GO:0009987 apical plasma membrane#GO:0016324;membrane#GO:0016020;neuron projection#GO:0043005;cell body#GO:0044297;cell periphery#GO:0071944;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;neuronal cell body#GO:0043025;cell projection#GO:0042995;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;plasma membrane bounded cell projection#GO:0120025;apical part of cell#GO:0045177 secondary carrier transporter#PC00258 HUMAN|HGNC=16516|UniProtKB=P57682 P57682 KLF3 PTHR23235:SF48 KRUEPPEL-LIKE TRANSCRIPTION FACTOR KRUEPPEL-LIKE FACTOR 3 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=5650|UniProtKB=P06331 P06331 IGHV4-34 PTHR23266:SF238 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 4-34 antigen binding#GO:0003823;binding#GO:0005488 immune effector process#GO:0002252;immune system process#GO:0002376;immunoglobulin mediated immune response#GO:0016064;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;immune response#GO:0006955;adaptive immune response#GO:0002250;response to stimulus#GO:0050896 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=30543|UniProtKB=Q7L8W6 Q7L8W6 DPH6 PTHR12196:SF2 DOMAIN OF UNKNOWN FUNCTION 71 DUF71 -CONTAINING PROTEIN DIPHTHINE--AMMONIA LIGASE catalytic activity#GO:0003824;ligase activity#GO:0016874;ligase activity, forming carbon-nitrogen bonds#GO:0016879 cellular process#GO:0009987;metabolic process#GO:0008152;primary metabolic process#GO:0044238;protein modification process#GO:0036211;macromolecule metabolic process#GO:0043170;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538 HUMAN|HGNC=16130|UniProtKB=Q6UDR6 Q6UDR6 SPINT4 PTHR47898:SF1 KUNITZ-TYPE PROTEASE INHIBITOR 4 KUNITZ-TYPE PROTEASE INHIBITOR 4 protease inhibitor#PC00191;protein-binding activity modulator#PC00095 HUMAN|HGNC=25549|UniProtKB=P0DP57 P0DP57 SLURP2 PTHR16983:SF14 UPAR/LY6 DOMAIN-CONTAINING PROTEIN SECRETED LY-6_UPAR DOMAIN-CONTAINING PROTEIN 2 binding#GO:0005488;acetylcholine receptor inhibitor activity#GO:0030550;signaling receptor binding#GO:0005102;acetylcholine receptor regulator activity#GO:0030548;signaling receptor inhibitor activity#GO:0030547;neurotransmitter receptor regulator activity#GO:0099602;molecular function inhibitor activity#GO:0140678;protein binding#GO:0005515;signaling receptor regulator activity#GO:0030545;molecular function regulator activity#GO:0098772 cell-cell signaling#GO:0007267;biological regulation#GO:0065007;response to chemical#GO:0042221;cellular response to nitrogen compound#GO:1901699;acetylcholine receptor signaling pathway#GO:0095500;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987;synaptic signaling#GO:0099536;response to nitrogen compound#GO:1901698;cell communication#GO:0007154;response to oxygen-containing compound#GO:1901700;cellular response to chemical stimulus#GO:0070887;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 protein-binding activity modulator#PC00095 HUMAN|HGNC=13540|UniProtKB=O75110 O75110 ATP9A PTHR24092:SF49 PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE PHOSPHOLIPID-TRANSPORTING ATPASE IIA-RELATED ATP-dependent activity#GO:0140657;transporter activity#GO:0005215;ATPase-coupled intramembrane lipid carrier activity#GO:0140326;molecular carrier activity#GO:0140104;lipid carrier activity#GO:0005319;intramembrane lipid carrier activity#GO:0140303 lipid transport#GO:0006869;vesicle-mediated transport#GO:0016192;phospholipid translocation#GO:0045332;biological regulation#GO:0065007;membrane organization#GO:0061024;phospholipid transport#GO:0015914;macromolecule localization#GO:0033036;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;import into cell#GO:0098657;establishment of localization#GO:0051234;regulation of membrane lipid distribution#GO:0097035;Golgi vesicle transport#GO:0048193;transport#GO:0006810;organophosphate ester transport#GO:0015748;endocytosis#GO:0006897;lipid translocation#GO:0034204;cellular component organization#GO:0016043;localization#GO:0051179;regulation of biological quality#GO:0065008;lipid localization#GO:0010876 endomembrane system#GO:0012505;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;plasma membrane#GO:0005886;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;cell periphery#GO:0071944;Golgi apparatus#GO:0005794;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;intracellular organelle#GO:0043229 transporter#PC00227;primary active transporter#PC00068 HUMAN|HGNC=28071|UniProtKB=Q96GE5 Q96GE5 ZNF799 PTHR24379:SF5 KRAB AND ZINC FINGER DOMAIN-CONTAINING ZINC FINGER PROTEIN 799-RELATED transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=9006|UniProtKB=O75364 O75364 PITX3 PTHR45882:SF2 PITUITARY HOMEOBOX HOMOLOG PTX1 PITUITARY HOMEOBOX 3 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;developmental process#GO:0032502;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119 HUMAN|HGNC=16803|UniProtKB=Q15386 Q15386 UBE3C PTHR45700:SF2 UBIQUITIN-PROTEIN LIGASE E3C UBIQUITIN-PROTEIN LIGASE E3C aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746 protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;cellular process#GO:0009987;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;catabolic process#GO:0009056;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;protein modification process#GO:0036211;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein modification by small protein conjugation or removal#GO:0070647 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 Ubiquitin proteasome pathway#P00060>E3#P01490 HUMAN|HGNC=25018|UniProtKB=Q9P0N5 Q9P0N5 TMEM216 PTHR13531:SF5 GEO07735P1-RELATED-RELATED TRANSMEMBRANE PROTEIN 216 cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cell projection assembly#GO:0030031;cellular process#GO:0009987;cell projection organization#GO:0030030;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031;non-motile cilium assembly#GO:1905515;cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782 cilium#GO:0005929;ciliary transition zone#GO:0035869;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=6781|UniProtKB=O15525 O15525 MAFG PTHR10129:SF15 TRANSCRIPTION FACTOR MAF TRANSCRIPTION FACTOR MAFG sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488 regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of developmental process#GO:0050793;regulation of multicellular organismal development#GO:2000026;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of multicellular organismal process#GO:0051239;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of epithelial cell differentiation#GO:0030856;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of cell differentiation#GO:0045595 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;basic leucine zipper transcription factor#PC00056 HUMAN|HGNC=4141|UniProtKB=P04406 P04406 GAPDH PTHR10836:SF111 GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE glyceraldehyde-3-phosphate dehydrogenase (phosphorylating, [NAD(P)+] ) activity#GO:0043891;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor#GO:0016620;oxidoreductase activity, acting on the aldehyde or oxo group of donors#GO:0016903;catalytic activity#GO:0003824 nucleobase-containing compound metabolic process#GO:0006139;organophosphate metabolic process#GO:0019637;nucleobase-containing compound catabolic process#GO:0034655;carbohydrate derivative metabolic process#GO:1901135;ribonucleotide catabolic process#GO:0009261;purine ribonucleoside triphosphate metabolic process#GO:0009205;glycolytic process#GO:0006096;ADP metabolic process#GO:0046031;energy derivation by oxidation of organic compounds#GO:0015980;nucleotide catabolic process#GO:0009166;generation of precursor metabolites and energy#GO:0006091;purine ribonucleoside diphosphate metabolic process#GO:0009179;catabolic process#GO:0009056;nucleoside phosphate catabolic process#GO:1901292;carbohydrate metabolic process#GO:0005975;nucleoside phosphate metabolic process#GO:0006753;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate derivative catabolic process#GO:1901136;primary metabolic process#GO:0044238;purine ribonucleotide catabolic process#GO:0009154;nucleoside diphosphate catabolic process#GO:0009134;purine nucleoside triphosphate metabolic process#GO:0009144;organophosphate catabolic process#GO:0046434;ribonucleoside diphosphate catabolic process#GO:0009191;cellular respiration#GO:0045333;purine ribonucleoside diphosphate catabolic process#GO:0009181;aerobic respiration#GO:0009060;nucleoside diphosphate metabolic process#GO:0009132;pyridine-containing compound metabolic process#GO:0072524;purine nucleotide catabolic process#GO:0006195;nicotinamide nucleotide metabolic process#GO:0046496;ribose phosphate metabolic process#GO:0019693;ATP metabolic process#GO:0046034;cellular process#GO:0009987;purine-containing compound catabolic process#GO:0072523;nucleobase-containing small molecule metabolic process#GO:0055086;purine nucleoside diphosphate catabolic process#GO:0009137;metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;ADP catabolic process#GO:0046032;small molecule metabolic process#GO:0044281;pyruvate metabolic process#GO:0006090;pyridine nucleotide catabolic process#GO:0019364;monocarboxylic acid metabolic process#GO:0032787;phosphorus metabolic process#GO:0006793;carboxylic acid metabolic process#GO:0019752;purine nucleotide metabolic process#GO:0006163;ribonucleoside diphosphate metabolic process#GO:0009185;pyridine-containing compound catabolic process#GO:0072526;purine-containing compound metabolic process#GO:0072521;nucleotide metabolic process#GO:0009117;carbohydrate catabolic process#GO:0016052;oxoacid metabolic process#GO:0043436;ribonucleotide metabolic process#GO:0009259;purine nucleoside diphosphate metabolic process#GO:0009135 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 dehydrogenase#PC00092 Huntington disease#P00029>GAPDH#P00810;Glycolysis#P00024>Glyceraldehyde 3-phosphate dehydrogenase#P00676 HUMAN|HGNC=5732|UniProtKB=P04430 P04430 IGKV1-16 PTHR23267:SF514 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN KAPPA VARIABLE 1-16-RELATED immune response#GO:0006955;immune system process#GO:0002376;response to stimulus#GO:0050896 protein-containing complex#GO:0032991 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=380|UniProtKB=P14550 P14550 AKR1A1 PTHR11732:SF385 ALDO/KETO REDUCTASE ALDO-KETO REDUCTASE FAMILY 1 MEMBER A1 oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;alcohol dehydrogenase (NADP+) activity#GO:0008106;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;catalytic activity#GO:0003824 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 reductase#PC00198;oxidoreductase#PC00176 HUMAN|HGNC=17393|UniProtKB=Q9H992 Q9H992 MARCHF7 PTHR14471:SF1 MARCH7/10 E3 UBIQUITIN PROTEIN LIGASE FAMILY MEMBER E3 UBIQUITIN-PROTEIN LIGASE MARCHF7 protein binding#GO:0005515;enzyme binding#GO:0019899;ubiquitin binding#GO:0043130;binding#GO:0005488 protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;primary metabolic process#GO:0044238;protein modification process#GO:0036211;cellular process#GO:0009987;protein modification by small protein conjugation#GO:0032446 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=26217|UniProtKB=Q5U3C3 Q5U3C3 TMEM164 PTHR20948:SF5 TRANSMEMBRANE PROTEIN 164 TRANSMEMBRANE PROTEIN 164 positive regulation of programmed cell death#GO:0043068;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of programmed cell death#GO:0043067;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;positive regulation of biological process#GO:0048518 HUMAN|HGNC=31708|UniProtKB=Q9Y561 Q9Y561 LRP12 PTHR24270:SF47 LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 12 anatomical structure development#GO:0048856;neuron development#GO:0048666;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;cell motility#GO:0048870;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell development#GO:0048468;cellular component organization#GO:0016043;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;neuron migration#GO:0001764;cellular component organization or biogenesis#GO:0071840;neurogenesis#GO:0022008;neuron differentiation#GO:0030182;developmental process#GO:0032502;multicellular organismal process#GO:0032501;cell migration#GO:0016477;plasma membrane bounded cell projection organization#GO:0120036;nervous system development#GO:0007399;neuron projection development#GO:0031175;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transfer/carrier protein#PC00219;apolipoprotein#PC00052 HUMAN|HGNC=23236|UniProtKB=Q9H3F6 Q9H3F6 KCTD10 PTHR11145:SF14 BTB/POZ DOMAIN-CONTAINING ADAPTER FOR CUL3-MEDIATED RHOA DEGRADATION PROTEIN FAMILY MEMBER BTB_POZ DOMAIN-CONTAINING ADAPTER FOR CUL3-MEDIATED RHOA DEGRADATION PROTEIN 3 modification-dependent protein catabolic process#GO:0019941;protein modification process#GO:0036211;primary metabolic process#GO:0044238;regulation of cell communication#GO:0010646;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;post-translational protein modification#GO:0043687;negative regulation of response to stimulus#GO:0048585;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein modification by small protein conjugation#GO:0032446;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of Rho protein signal transduction#GO:0035023;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;protein modification by small protein conjugation or removal#GO:0070647;regulation of intracellular signal transduction#GO:1902531;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;cellular process#GO:0009987;protein ubiquitination#GO:0016567;negative regulation of signal transduction#GO:0009968;proteasomal protein catabolic process#GO:0010498;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;regulation of small GTPase mediated signal transduction#GO:0051056 transferase complex#GO:1990234;catalytic complex#GO:1902494;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;Cul3-RING ubiquitin ligase complex#GO:0031463;intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461 scaffold/adaptor protein#PC00226 HUMAN|HGNC=23989|UniProtKB=Q96QU6 Q96QU6 ACCS PTHR43795:SF17 BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED 1-AMINOCYCLOPROPANE-1-CARBOXYLATE SYNTHASE-LIKE PROTEIN 1 catalytic activity#GO:0003824;carbon-sulfur lyase activity#GO:0016846;lyase activity#GO:0016829 transferase#PC00220;transaminase#PC00216;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=37204|UniProtKB=A6NJ08 A6NJ08 MBD3L5 PTHR12396:SF6 METHYL-CPG BINDING PROTEIN, MBD METHYL-CPG-BINDING DOMAIN PROTEIN 3-LIKE 2-RELATED regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;chromatin organization#GO:0006325;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;epigenetic regulation of gene expression#GO:0040029;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of cellular process#GO:0048523;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;heterochromatin formation#GO:0031507;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of DNA-templated transcription#GO:0006355;heterochromatin organization#GO:0070828;cellular component assembly#GO:0022607;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;constitutive heterochromatin formation#GO:0140719;negative regulation of gene expression, epigenetic#GO:0045814;DNA methylation-dependent constitutive heterochromatin formation#GO:0006346;cellular component organization or biogenesis#GO:0071840;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=2265|UniProtKB=P13073 P13073 COX4I1 PTHR10707:SF12 CYTOCHROME C OXIDASE SUBUNIT IV CYTOCHROME C OXIDASE SUBUNIT 4 ISOFORM 1, MITOCHONDRIAL generation of precursor metabolites and energy#GO:0006091;metabolic process#GO:0008152;aerobic electron transport chain#GO:0019646;mitochondrial electron transport, cytochrome c to oxygen#GO:0006123;aerobic respiration#GO:0009060;oxidative phosphorylation#GO:0006119;ATP synthesis coupled electron transport#GO:0042773;energy derivation by oxidation of organic compounds#GO:0015980;cellular respiration#GO:0045333;mitochondrial ATP synthesis coupled electron transport#GO:0042775;cellular process#GO:0009987;respiratory electron transport chain#GO:0022904;electron transport chain#GO:0022900 catalytic complex#GO:1902494;intracellular organelle#GO:0043229;respiratory chain complex IV#GO:0045277;transmembrane transporter complex#GO:1902495;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle envelope#GO:0031967;membrane protein complex#GO:0098796;mitochondrion#GO:0005739;cytochrome complex#GO:0070069;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;transporter complex#GO:1990351;organelle membrane#GO:0031090;oxidoreductase complex#GO:1990204;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;respiratory chain complex#GO:0098803;mitochondrial membrane#GO:0031966;protein-containing complex#GO:0032991;cytoplasm#GO:0005737 oxidase#PC00175;oxidoreductase#PC00176 HUMAN|HGNC=11731|UniProtKB=Q15569 Q15569 TESK1 PTHR46485:SF3 LIM DOMAIN KINASE 1 DUAL SPECIFICITY TESTIS-SPECIFIC PROTEIN KINASE 1 transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 actin filament-based process#GO:0030029;positive regulation of cellular component organization#GO:0051130;positive regulation of organelle organization#GO:0010638;cellular component organization#GO:0016043;regulation of actin filament bundle assembly#GO:0032231;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of supramolecular fiber organization#GO:1902903;regulation of cellular process#GO:0050794;actin cytoskeleton organization#GO:0030036;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;regulation of cellular component biogenesis#GO:0044087;regulation of stress fiber assembly#GO:0051492;regulation of actin filament-based process#GO:0032970;cellular component organization or biogenesis#GO:0071840;positive regulation of actin filament bundle assembly#GO:0032233;organelle organization#GO:0006996;cellular process#GO:0009987;regulation of actin filament organization#GO:0110053;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of cellular component biogenesis#GO:0044089;regulation of actin cytoskeleton organization#GO:0032956;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 HUMAN|HGNC=11840|UniProtKB=Q04727 Q04727 TLE4 PTHR10814:SF31 TRANSDUCIN-LIKE ENHANCER PROTEIN TRANSDUCIN-LIKE ENHANCER PROTEIN 4 transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714;transcription regulator activity#GO:0140110 negative regulation of response to stimulus#GO:0048585;negative regulation of Wnt signaling pathway#GO:0030178;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of canonical Wnt signaling pathway#GO:0060828;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of cell communication#GO:0010648;negative regulation of signaling#GO:0023057;negative regulation of canonical Wnt signaling pathway#GO:0090090;regulation of signaling#GO:0023051 transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634 transcription cofactor#PC00217 Wnt signaling pathway#P00057>Transducin-like Enhance of Split 1-3#P01436 HUMAN|HGNC=19958|UniProtKB=O15091 O15091 PRORP PTHR13547:SF23 RIBONUCLEASE P MITOCHONDRIAL RIBONUCLEASE P CATALYTIC SUBUNIT catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;RNA nuclease activity#GO:0004540;endonuclease activity#GO:0004519;RNA endonuclease activity#GO:0004521;catalytic activity, acting on RNA#GO:0140098;ribonuclease P activity#GO:0004526;hydrolase activity#GO:0016787;nuclease activity#GO:0004518;catalytic activity, acting on a tRNA#GO:0140101 nucleic acid biosynthetic process#GO:0141187;mitochondrial RNA metabolic process#GO:0000959;RNA metabolic process#GO:0016070;mitochondrial gene expression#GO:0140053;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;mitochondrial RNA processing#GO:0000963;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058 intracellular protein-containing complex#GO:0140535;endonuclease complex#GO:1905348;cytoplasm#GO:0005737;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;endoribonuclease complex#GO:1902555;ribonuclease P complex#GO:0030677;ribonucleoprotein complex#GO:1990904;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739 HUMAN|HGNC=8466|UniProtKB=Q8NG99 Q8NG99 OR7G2 PTHR48001:SF96 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 7G2 transmembrane signal receptor#PC00197 HUMAN|HGNC=28786|UniProtKB=Q7Z5U6 Q7Z5U6 WDR53 PTHR44666:SF1 WD REPEAT-CONTAINING PROTEIN 53 WD REPEAT-CONTAINING PROTEIN 53 HUMAN|HGNC=23694|UniProtKB=Q8N6U8 Q8N6U8 GPR161 PTHR22752:SF10 G PROTEIN-COUPLED RECEPTOR G PROTEIN-COUPLED RECEPTOR 161 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930 cell communication#GO:0007154;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 intracellular organelle#GO:0043229;endosome#GO:0005768;recycling endosome#GO:0055037;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=1188|UniProtKB=P56378 P56378 ATP5MJ PTHR15233:SF1 MITOCHONDRIAL PROTEOLIPID ATP SYNTHASE F(0) COMPLEX SUBUNIT J, MITOCHONDRIAL cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;proton-transporting ATP synthase complex#GO:0045259;membrane#GO:0016020;membrane protein complex#GO:0098796;respiratory chain complex#GO:0098803;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;proton-transporting two-sector ATPase complex#GO:0016469;cation channel complex#GO:0034703;catalytic complex#GO:1902494 HUMAN|HGNC=25236|UniProtKB=Q9NUC0 Q9NUC0 SERTAD4 PTHR14272:SF4 SERTA DOMAIN-CONTAINING PROTEIN 4 SERTA DOMAIN-CONTAINING PROTEIN 4 HUMAN|HGNC=35406|UniProtKB=P0CB48 P0CB48 UBTFL6 PTHR46318:SF1 UPSTREAM BINDING TRANSCRIPTION FACTOR UPSTREAM-BINDING FACTOR 1-LIKE PROTEIN 1-RELATED transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;core promoter sequence-specific DNA binding#GO:0001046;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 cellular process#GO:0009987;positive regulation of biological process#GO:0048518;gene expression#GO:0010467;positive regulation of macromolecule metabolic process#GO:0010604;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;regulation of biological process#GO:0050789;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;transcription by RNA polymerase I#GO:0006360;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;macromolecule biosynthetic process#GO:0009059;positive regulation of cellular process#GO:0048522;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;biosynthetic process#GO:0009058;regulation of RNA biosynthetic process#GO:2001141;nucleobase-containing compound metabolic process#GO:0006139;positive regulation of transcription by RNA polymerase I#GO:0045943;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulation of gene expression#GO:0010468;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;DNA-templated transcription#GO:0006351;positive regulation of RNA metabolic process#GO:0051254;RNA biosynthetic process#GO:0032774;regulation of transcription by RNA polymerase I#GO:0006356;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HUMAN|HGNC=18971|UniProtKB=Q96PC3 Q96PC3 AP1S3 PTHR11753:SF18 ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY AP-1 COMPLEX SUBUNIT SIGMA-3 localization#GO:0051179;vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;cellular process#GO:0009987;transport#GO:0006810 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229 membrane traffic protein#PC00150;vesicle coat protein#PC00235 HUMAN|HGNC=15942|UniProtKB=Q9P2W9 Q9P2W9 STX18 PTHR15959:SF1 SYNTAXIN-18 SYNTAXIN-18 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;SNAP receptor activity#GO:0005484 cellular process#GO:0009987;transport#GO:0006810;Golgi vesicle transport#GO:0048193;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;establishment of localization#GO:0051234;vesicle-mediated transport#GO:0016192;localization#GO:0051179 organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;SNARE complex#GO:0031201;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane protein complex#GO:0098796;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 membrane traffic protein#PC00150;SNARE protein#PC00034 HUMAN|HGNC=23405|UniProtKB=Q9H2I8 Q9H2I8 LRMDA PTHR46282:SF4 LEUCINE-RICH MELANOCYTE DIFFERENTIATION-ASSOCIATED PROTEIN LEUCINE-RICH MELANOCYTE DIFFERENTIATION-ASSOCIATED PROTEIN cell differentiation#GO:0030154;cellular developmental process#GO:0048869;developmental process#GO:0032502;pigmentation#GO:0043473;melanocyte differentiation#GO:0030318;cellular process#GO:0009987;developmental pigmentation#GO:0048066 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=8712|UniProtKB=Q9Y5G0 Q9Y5G0 PCDHGB5 PTHR24028:SF350 CADHERIN-87A PROTOCADHERIN GAMMA-B3-RELATED cellular process#GO:0009987;cell adhesion#GO:0007155 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 cadherin#PC00057;cell adhesion molecule#PC00069 HUMAN|HGNC=7128|UniProtKB=Q9UHC1 Q9UHC1 MLH3 PTHR10073:SF47 DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL DNA MISMATCH REPAIR PROTEIN MLH3 sequence-specific double-stranded DNA binding#GO:1990837;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488 cellular response to stress#GO:0033554;DNA damage response#GO:0006974;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;mismatch repair#GO:0006298;cellular response to stimulus#GO:0051716;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;primary metabolic process#GO:0044238;nucleobase-containing compound metabolic process#GO:0006139;response to stimulus#GO:0050896 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622 DNA metabolism protein#PC00009 HUMAN|HGNC=26976|UniProtKB=Q96DE5 Q96DE5 ANAPC16 PTHR31564:SF0 ANAPHASE-PROMOTING COMPLEX SUBUNIT 16 ANAPHASE-PROMOTING COMPLEX SUBUNIT 16 protein modification by small protein conjugation#GO:0032446;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647;macromolecule metabolic process#GO:0043170;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538 ubiquitin ligase complex#GO:0000151;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;nuclear ubiquitin ligase complex#GO:0000152;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cullin-RING ubiquitin ligase complex#GO:0031461;chromosome#GO:0005694;kinetochore#GO:0000776;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;chromosome, centromeric region#GO:0000775;condensed chromosome#GO:0000793;transferase complex#GO:1990234;anaphase-promoting complex#GO:0005680;protein-containing complex#GO:0032991;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;condensed chromosome, centromeric region#GO:0000779;cytosol#GO:0005829;nucleus#GO:0005634 HUMAN|HGNC=19871|UniProtKB=Q7Z5H5 Q7Z5H5 VN1R4 PTHR24062:SF181 VOMERONASAL TYPE-1 RECEPTOR VOMERONASAL TYPE-1 RECEPTOR 4 binding#GO:0005488 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=23721|UniProtKB=Q7Z2W4 Q7Z2W4 ZC3HAV1 PTHR45740:SF8 POLY [ADP-RIBOSE] POLYMERASE ZINC FINGER CCCH-TYPE ANTIVIRAL PROTEIN 1 catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757;protein-RNA adaptor activity#GO:0140517;catalytic activity#GO:0003824;transferase activity#GO:0016740;molecular adaptor activity#GO:0060090;pentosyltransferase activity#GO:0016763;protein-macromolecule adaptor activity#GO:0030674;NAD+ poly-ADP-ribosyltransferase activity#GO:0003950 protein metabolic process#GO:0019538;response to nitrogen compound#GO:1901698;positive regulation of cell communication#GO:0010647;response to external biotic stimulus#GO:0043207;regulation of response to biotic stimulus#GO:0002831;positive regulation of mRNA catabolic process#GO:0061014;response to external stimulus#GO:0009605;regulation of gene expression#GO:0010468;regulation of response to stress#GO:0080134;positive regulation of intracellular signal transduction#GO:1902533;cellular response to nitrogen compound#GO:1901699;regulation of signal transduction#GO:0009966;response to other organism#GO:0051707;post-translational protein modification#GO:0043687;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of innate immune response#GO:0045089;positive regulation of metabolic process#GO:0009893;positive regulation of signaling#GO:0023056;regulation of intracellular signal transduction#GO:1902531;biological process involved in interspecies interaction between organisms#GO:0044419;regulation of mRNA catabolic process#GO:0061013;positive regulation of response to external stimulus#GO:0032103;metabolic process#GO:0008152;positive regulation of mRNA metabolic process#GO:1903313;response to chemical#GO:0042221;macromolecule modification#GO:0043412;response to virus#GO:0009615;regulation of RNA metabolic process#GO:0051252;regulation of immune response#GO:0050776;regulation of defense response#GO:0031347;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of cell communication#GO:0010646;positive regulation of RNA metabolic process#GO:0051254;positive regulation of signal transduction#GO:0009967;primary metabolic process#GO:0044238;protein modification process#GO:0036211;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;regulation of innate immune response#GO:0045088;regulation of biosynthetic process#GO:0009889;positive regulation of catabolic process#GO:0009896;positive regulation of response to biotic stimulus#GO:0002833;regulation of catabolic process#GO:0009894;positive regulation of immune response#GO:0050778;positive regulation of defense response#GO:0031349;regulation of response to stimulus#GO:0048583;positive regulation of response to stimulus#GO:0048584;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;cellular response to chemical stimulus#GO:0070887;regulation of signaling#GO:0023051;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;regulation of mRNA metabolic process#GO:1903311;positive regulation of macromolecule metabolic process#GO:0010604;regulation of response to external stimulus#GO:0032101;response to biotic stimulus#GO:0009607;positive regulation of pattern recognition receptor signaling pathway#GO:0062208;positive regulation of immune system process#GO:0002684;positive regulation of biological process#GO:0048518;cellular process#GO:0009987 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;cytosol#GO:0005829 HUMAN|HGNC=23590|UniProtKB=B3EWG6 B3EWG6 FAM25G PTHR34994:SF1 PROTEIN FAM25A-RELATED PROTEIN FAM25A-RELATED HUMAN|HGNC=966|UniProtKB=Q8NFJ9 Q8NFJ9 BBS1 PTHR20870:SF0 BARDET-BIEDL SYNDROME 1 PROTEIN BBSOME COMPLEX MEMBER BBS1 protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102;G protein-coupled receptor binding#GO:0001664 cellular component organization#GO:0016043;cilium assembly#GO:0060271;protein localization to organelle#GO:0033365;cell projection organization#GO:0030030;protein localization to cilium#GO:0061512;organelle assembly#GO:0070925;localization#GO:0051179;non-motile cilium assembly#GO:1905515;cilium organization#GO:0044782;organelle organization#GO:0006996;macromolecule localization#GO:0033036;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;plasma membrane bounded cell projection assembly#GO:0120031;cellular component organization or biogenesis#GO:0071840;intracellular protein localization#GO:0008104 cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;intracellular organelle#GO:0043229;cilium#GO:0005929;axoneme#GO:0005930;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;microtubule cytoskeleton#GO:0015630;ciliary plasm#GO:0097014;protein-containing complex#GO:0032991;BBSome#GO:0034464;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;centrosome#GO:0005813;microtubule organizing center#GO:0005815;membraneless organelle#GO:0043228 HUMAN|HGNC=28836|UniProtKB=Q9H019 Q9H019 MTFR1L PTHR14215:SF3 PROTEIN OF UNKNOWN FUNCTION DUF729 MITOCHONDRIAL FISSION REGULATOR 1-LIKE generation of precursor metabolites and energy#GO:0006091;metabolic process#GO:0008152;aerobic respiration#GO:0009060;cellular component organization or biogenesis#GO:0071840;organelle fission#GO:0048285;energy derivation by oxidation of organic compounds#GO:0015980;cellular respiration#GO:0045333;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;mitochondrion organization#GO:0007005;mitochondrial fission#GO:0000266 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=4023|UniProtKB=P51114 P51114 FXR1 PTHR10603:SF6 FRAGILE X MENTAL RETARDATION SYNDROME-RELATED PROTEIN RNA-BINDING PROTEIN FXR1 mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA 3'-UTR binding#GO:0003730 positive regulation of cell differentiation#GO:0045597;animal organ development#GO:0048513;regulation of mRNA metabolic process#GO:1903311;positive regulation of biological process#GO:0048518;regulation of protein metabolic process#GO:0051246;positive regulation of cell development#GO:0010720;regulation of multicellular organismal process#GO:0051239;positive regulation of macromolecule metabolic process#GO:0010604;regulation of trans-synaptic signaling#GO:0099177;regulation of signaling#GO:0023051;positive regulation of protein metabolic process#GO:0051247;animal gross anatomical part developmental process#GO:0160108;regulation of biological quality#GO:0065008;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of biological process#GO:0050789;regulation of multicellular organismal development#GO:2000026;positive regulation of multicellular organismal process#GO:0051240;regulation of mRNA catabolic process#GO:0061013;regulation of mRNA stability#GO:0043488;positive regulation of nervous system development#GO:0051962;positive regulation of developmental process#GO:0051094;developmental process#GO:0032502;transport#GO:0006810;regulation of cell differentiation#GO:0045595;regulation of synaptic plasticity#GO:0048167;post-transcriptional regulation of gene expression#GO:0010608;positive regulation of gene expression#GO:0010628;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;regulation of neuronal synaptic plasticity#GO:0048168;regulation of biosynthetic process#GO:0009889;establishment of localization#GO:0051234;positive regulation of cellular process#GO:0048522;regulation of cell development#GO:0060284;macromolecule localization#GO:0033036;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;nitrogen compound transport#GO:0071705;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA stability#GO:0043487;positive regulation of translation#GO:0045727;regulation of RNA metabolic process#GO:0051252;localization#GO:0051179;positive regulation of biosynthetic process#GO:0009891;regulation of nervous system development#GO:0051960;anatomical structure development#GO:0048856;nucleic acid transport#GO:0050657;regulation of neurogenesis#GO:0050767;mRNA transport#GO:0051028;modulation of chemical synaptic transmission#GO:0050804;establishment of RNA localization#GO:0051236;regulation of developmental process#GO:0050793;positive regulation of neurogenesis#GO:0050769;regulation of cell communication#GO:0010646;regulation of macromolecule metabolic process#GO:0060255;nucleobase-containing compound transport#GO:0015931;RNA transport#GO:0050658;regulation of cellular process#GO:0050794;RNA localization#GO:0006403 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;cell projection#GO:0042995;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;membraneless organelle#GO:0043228;cytoplasmic stress granule#GO:0010494;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;neuron projection#GO:0043005;nucleus#GO:0005634 translation factor#PC00223;translational protein#PC00263 HUMAN|HGNC=16101|UniProtKB=Q5JX69 Q5JX69 FAM209B PTHR35157:SF4 PROTEIN FAM209A PROTEIN FAM209B HUMAN|HGNC=32037|UniProtKB=Q5VUY0 Q5VUY0 AADACL3 PTHR23024:SF115 ARYLACETAMIDE DEACETYLASE ARYLACETAMIDE DEACETYLASE-LIKE 3 membrane#GO:0016020;cellular anatomical structure#GO:0110165 deacetylase#PC00087 HUMAN|HGNC=9087|UniProtKB=Q04941 Q04941 PLP2 PTHR22776:SF4 MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN PROTEOLIPID PROTEIN 2 response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;immune system process#GO:0002376;immune response#GO:0006955;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HUMAN|HGNC=28378|UniProtKB=Q9BTM9 Q9BTM9 URM1 PTHR14986:SF4 RURM1 PROTEIN UBIQUITIN-RELATED MODIFIER 1 post-translational protein modification#GO:0043687;primary metabolic process#GO:0044238;protein modification process#GO:0036211;cellular process#GO:0009987;protein modification by small protein conjugation#GO:0032446;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=26886|UniProtKB=Q6ZMZ0 Q6ZMZ0 RNF19B PTHR11685:SF109 RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING E3 UBIQUITIN-PROTEIN LIGASE RNF19B ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;protein binding#GO:0005515;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;enzyme binding#GO:0019899;acyltransferase activity#GO:0016746;binding#GO:0005488;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824 catabolic process#GO:0009056;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632 ubiquitin ligase complex#GO:0000151;lytic vacuole#GO:0000323;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;transferase complex#GO:1990234;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;vacuole#GO:0005773;lysosome#GO:0005764 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=12806|UniProtKB=P55808 P55808 XG PTHR15076:SF4 CD99/MIC2 PROTEIN RELATED GLYCOPROTEIN XG positive regulation of cell motility#GO:2000147;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;cell motility#GO:0048870;regulation of leukocyte migration#GO:0002685;mononuclear cell migration#GO:0071674;immune system process#GO:0002376;cell adhesion#GO:0007155;regulation of cell motility#GO:2000145;positive regulation of immune system process#GO:0002684;cell-cell adhesion#GO:0098609;lymphocyte migration#GO:0072676;positive regulation of cell migration#GO:0030335;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cell migration#GO:0016477;homotypic cell-cell adhesion#GO:0034109;regulation of locomotion#GO:0040012;biological regulation#GO:0065007;leukocyte migration#GO:0050900;regulation of cell migration#GO:0030334;positive regulation of locomotion#GO:0040017 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 HUMAN|HGNC=21034|UniProtKB=Q9P032 Q9P032 NDUFAF4 PTHR13338:SF6 UPF0240 PROTEIN NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 4 NADH dehydrogenase complex assembly#GO:0010257;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;mitochondrial respiratory chain complex assembly#GO:0033108;mitochondrion organization#GO:0007005;cellular component assembly#GO:0022607;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;mitochondrial respiratory chain complex I assembly#GO:0032981 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739 HUMAN|HGNC=11087|UniProtKB=O75094 O75094 SLIT3 PTHR45836:SF9 SLIT HOMOLOG SLIT HOMOLOG 3 PROTEIN protein binding#GO:0005515;heparin binding#GO:0008201;carbohydrate derivative binding#GO:0097367;glycosaminoglycan binding#GO:0005539;binding#GO:0005488;signaling receptor binding#GO:0005102 nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;taxis#GO:0042330;response to chemical#GO:0042221;cellular process#GO:0009987;neuron projection development#GO:0031175;cell projection morphogenesis#GO:0048858;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell development#GO:0048468;cell differentiation#GO:0030154;response to stimulus#GO:0050896;cell projection organization#GO:0030030;cell morphogenesis#GO:0000902;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;axonogenesis#GO:0007409;neuron development#GO:0048666;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;plasma membrane bounded cell projection organization#GO:0120036;multicellular organismal process#GO:0032501;axon development#GO:0061564;axon guidance#GO:0007411;response to external stimulus#GO:0009605;neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;locomotion#GO:0040011;system development#GO:0048731;anatomical structure development#GO:0048856;chemotaxis#GO:0006935 Axon guidance mediated by Slit/Robo#P00008>Slit#P00342 HUMAN|HGNC=6360|UniProtKB=Q9UKR0 Q9UKR0 KLK12 PTHR24271:SF63 KALLIKREIN-RELATED KALLIKREIN-12 catalytic activity#GO:0003824;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;secretory vesicle#GO:0099503;vesicle#GO:0031982;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;extracellular region#GO:0005576 serine protease#PC00203 HUMAN|HGNC=1490|UniProtKB=P47755 P47755 CAPZA2 PTHR10653:SF2 F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA-2 binding#GO:0005488;actin filament binding#GO:0051015;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;protein binding#GO:0005515;protein-containing complex binding#GO:0044877 cytoskeleton organization#GO:0007010;regulation of actin cytoskeleton organization#GO:0032956;cellular process#GO:0009987;organelle organization#GO:0006996;regulation of protein-containing complex disassembly#GO:0043244;cellular component organization or biogenesis#GO:0071840;regulation of anatomical structure size#GO:0090066;negative regulation of actin filament polymerization#GO:0030837;regulation of cellular component biogenesis#GO:0044087;regulation of cellular component organization#GO:0051128;regulation of biological process#GO:0050789;regulation of cellular component size#GO:0032535;regulation of organelle organization#GO:0033043;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;regulation of protein-containing complex assembly#GO:0043254;regulation of biological quality#GO:0065008;negative regulation of actin filament depolymerization#GO:0030835;regulation of actin filament length#GO:0030832;biological regulation#GO:0065007;regulation of actin polymerization or depolymerization#GO:0008064;negative regulation of protein depolymerization#GO:1901880;regulation of actin filament polymerization#GO:0030833;regulation of actin filament organization#GO:0110053;regulation of protein depolymerization#GO:1901879;regulation of actin filament-based process#GO:0032970;negative regulation of cellular process#GO:0048523;regulation of actin filament depolymerization#GO:0030834;negative regulation of supramolecular fiber organization#GO:1902904;regulation of cytoskeleton organization#GO:0051493;regulation of protein polymerization#GO:0032271;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;regulation of supramolecular fiber organization#GO:1902903;negative regulation of organelle organization#GO:0010639;negative regulation of cellular component organization#GO:0051129;negative regulation of protein-containing complex assembly#GO:0031333;negative regulation of cytoskeleton organization#GO:0051494;negative regulation of protein-containing complex disassembly#GO:0043242;actin filament capping#GO:0051693;negative regulation of protein polymerization#GO:0032272;actin filament-based process#GO:0030029 cell periphery#GO:0071944;cell cortex#GO:0005938;cortical cytoskeleton#GO:0030863;actin cytoskeleton#GO:0015629;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 non-motor actin binding protein#PC00165 HUMAN|HGNC=22971|UniProtKB=P60411 P60411 KRTAP10-9 PTHR23262:SF170 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 10-9 structural protein#PC00211 HUMAN|HGNC=25743|UniProtKB=Q4KMZ8 Q4KMZ8 NKAIN1 PTHR13084:SF4 T-CELL LYMPHOMA BREAKPOINT-ASSOCIATED TARGET 1-RELATED SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA-1-INTERACTING PROTEIN 1 regulation of biological process#GO:0050789;regulation of localization#GO:0032879;biological regulation#GO:0065007;regulation of transport#GO:0051049;regulation of metal ion transport#GO:0010959;regulation of monoatomic ion transport#GO:0043269 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 HUMAN|HGNC=24641|UniProtKB=Q7Z3J2 Q7Z3J2 VPS35L PTHR13673:SF0 ESOPHAGEAL CANCER ASSOCIATED PROTEIN VPS35 ENDOSOMAL PROTEIN-SORTING FACTOR-LIKE establishment of localization in cell#GO:0051649;cellular process#GO:0009987;endocytic recycling#GO:0032456;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;localization within membrane#GO:0051668;transport#GO:0006810;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;endosomal transport#GO:0016197;vesicle-mediated transport to the plasma membrane#GO:0098876 vesicle#GO:0031982;intracellular vesicle#GO:0097708;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410 HUMAN|HGNC=21393|UniProtKB=Q9Y3V2 Q9Y3V2 RWDD3 PTHR15628:SF1 RWD DOMAIN-CONTAINING PROTEIN 3 RWD DOMAIN-CONTAINING PROTEIN 3 positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cell communication#GO:0010646;positive regulation of response to stimulus#GO:0048584;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;positive regulation of intracellular signal transduction#GO:1902533;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;regulation of intracellular signal transduction#GO:1902531;positive regulation of signaling#GO:0023056 HUMAN|HGNC=9326|UniProtKB=Q9UMR5 Q9UMR5 PPT2 PTHR11247:SF27 PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1 LYSOSOMAL THIOESTERASE PPT2 lytic vacuole#GO:0000323;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;extracellular region#GO:0005576;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vacuole#GO:0005773;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;lysosome#GO:0005764 protein modifying enzyme#PC00260 HUMAN|HGNC=27296|UniProtKB=Q8N0U2 Q8N0U2 TMEM61 PTHR37151:SF1 TRANSMEMBRANE PROTEIN 61 TRANSMEMBRANE PROTEIN 61 HUMAN|HGNC=11845|UniProtKB=Q9Y490 Q9Y490 TLN1 PTHR19981:SF7 TALIN TALIN-1 cell adhesion molecule binding#GO:0050839;signaling receptor binding#GO:0005102;binding#GO:0005488;integrin binding#GO:0005178;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;cell-cell adhesion#GO:0098609;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;cell adhesion#GO:0007155;actin filament-based process#GO:0030029;cellular component organization or biogenesis#GO:0071840 cell periphery#GO:0071944;membrane#GO:0016020;cytoplasm#GO:0005737;cell-substrate junction#GO:0030055;focal adhesion#GO:0005925;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;cell junction#GO:0030054 Integrin signalling pathway#P00034>Talin#P00943 HUMAN|HGNC=55710|UniProtKB=P0DX00 P0DX00 GOLGA6L24 PTHR23143:SF31 TRICHOHYALIN-RELATED GOLGIN SUBFAMILY A MEMBER 6-LIKE PROTEIN 1-RELATED actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=51180|UniProtKB=D6REC4 D6REC4 CFAP99 PTHR34649:SF1 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 99 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 99 structural protein#PC00211 HUMAN|HGNC=18582|UniProtKB=O95490 O95490 ADGRL2 PTHR12011:SF61 ADHESION G-PROTEIN COUPLED RECEPTOR ADHESION G PROTEIN-COUPLED RECEPTOR L2 molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=663|UniProtKB=P05089 P05089 ARG1 PTHR43782:SF2 ARGINASE ARGINASE-1 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;catalytic activity#GO:0003824;metal ion binding#GO:0046872;hydrolase activity#GO:0016787;cation binding#GO:0043169;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;transition metal ion binding#GO:0046914 negative regulation of T cell activation#GO:0050868;regulation of cell population proliferation#GO:0042127;negative regulation of multicellular organismal process#GO:0051241;primary metabolic process#GO:0044238;negative regulation of leukocyte cell-cell adhesion#GO:1903038;regulation of T cell proliferation#GO:0042129;regulation of cell-cell adhesion#GO:0022407;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of leukocyte cell-cell adhesion#GO:1903037;negative regulation of cellular process#GO:0048523;negative regulation of cell activation#GO:0050866;negative regulation of cell population proliferation#GO:0008285;biological regulation#GO:0065007;biosynthetic process#GO:0009058;negative regulation of immune system process#GO:0002683;amino acid metabolic process#GO:0006520;negative regulation of cell adhesion#GO:0007162;regulation of cell adhesion#GO:0030155;regulation of lymphocyte proliferation#GO:0050670;oxoacid metabolic process#GO:0043436;regulation of biological process#GO:0050789;regulation of cell activation#GO:0050865;negative regulation of biological process#GO:0048519;regulation of leukocyte activation#GO:0002694;carboxylic acid metabolic process#GO:0019752;regulation of lymphocyte activation#GO:0051249;small molecule metabolic process#GO:0044281;metabolic process#GO:0008152;negative regulation of T cell proliferation#GO:0042130;regulation of leukocyte proliferation#GO:0070663;cellular process#GO:0009987;regulation of mononuclear cell proliferation#GO:0032944;negative regulation of leukocyte activation#GO:0002695;arginine metabolic process#GO:0006525;negative regulation of lymphocyte activation#GO:0051250;regulation of multicellular organismal process#GO:0051239;negative regulation of cell-cell adhesion#GO:0022408;regulation of T cell activation#GO:0050863 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HUMAN|HGNC=16097|UniProtKB=Q9UJQ1 Q9UJQ1 LAMP5 PTHR11506:SF45 LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN 5 establishment of protein localization#GO:0045184;establishment of protein localization to organelle#GO:0072594;localization#GO:0051179;establishment of localization#GO:0051234 late endosome membrane#GO:0031902;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;lytic vacuole#GO:0000323;vacuolar membrane#GO:0005774;cell periphery#GO:0071944;lysosomal membrane#GO:0005765;vesicle membrane#GO:0012506;membrane#GO:0016020;vacuole#GO:0005773;plasma membrane#GO:0005886;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;late endosome#GO:0005770;intracellular organelle#GO:0043229;endosome#GO:0005768;endosome membrane#GO:0010008;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;vesicle#GO:0031982;lysosome#GO:0005764;lytic vacuole membrane#GO:0098852;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=9278|UniProtKB=O15355 O15355 PPM1G PTHR13832:SF872 PROTEIN PHOSPHATASE 2C PROTEIN PHOSPHATASE 1G hydrolase activity#GO:0016787;protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154 organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195 HUMAN|HGNC=18332|UniProtKB=Q17RP2 Q17RP2 TIGD6 PTHR19303:SF52 TRANSPOSON TIGGER TRANSPOSABLE ELEMENT-DERIVED PROTEIN 6 DNA binding#GO:0003677;nucleic acid binding#GO:0003676;binding#GO:0005488 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 viral or transposable element protein#PC00237 HUMAN|HGNC=2851|UniProtKB=Q16760 Q16760 DGKD PTHR11255:SF30 DIACYLGLYCEROL KINASE DIACYLGLYCEROL KINASE DELTA kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;lipid kinase activity#GO:0001727;phosphotransferase activity, alcohol group as acceptor#GO:0016773 cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;signaling#GO:0023052;phospholipid metabolic process#GO:0006644;phospholipid biosynthetic process#GO:0008654;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;glycerolipid metabolic process#GO:0046486;intracellular signal transduction#GO:0035556;organophosphate biosynthetic process#GO:0090407;cell communication#GO:0007154;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;signal transduction#GO:0007165;organophosphate metabolic process#GO:0019637;biosynthetic process#GO:0009058;biological regulation#GO:0065007;lipid biosynthetic process#GO:0008610;glycerophospholipid metabolic process#GO:0006650;lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474;acylglycerol metabolic process#GO:0006639;metabolic process#GO:0008152;neutral lipid metabolic process#GO:0006638 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 metabolite interconversion enzyme#PC00262;kinase#PC00137 HUMAN|HGNC=22564|UniProtKB=A4D263 A4D263 SPMIP7 PTHR34759:SF1 SPERMATOGENESIS-ASSOCIATED PROTEIN 48 PROTEIN SPMIP7 gamete generation#GO:0007276;male gamete generation#GO:0048232;reproductive process#GO:0022414;developmental process involved in reproduction#GO:0003006;multicellular organismal reproductive process#GO:0048609;developmental process#GO:0032502;spermatogenesis#GO:0007283;sexual reproduction#GO:0019953 HUMAN|HGNC=1760|UniProtKB=Q9HBT6 Q9HBT6 CDH20 PTHR24027:SF84 CADHERIN-23 CADHERIN-20 beta-catenin binding#GO:0008013;protein binding#GO:0005515;cell adhesion molecule binding#GO:0050839;binding#GO:0005488 cell adhesion#GO:0007155;anatomical structure development#GO:0048856;adherens junction organization#GO:0034332;cell junction assembly#GO:0034329;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cell morphogenesis#GO:0000902;cell junction organization#GO:0034330;cell motility#GO:0048870;cell-cell junction organization#GO:0045216;developmental process#GO:0032502;cell-cell junction assembly#GO:0007043;cellular component organization or biogenesis#GO:0071840;cellular component biogenesis#GO:0044085;cell-cell adhesion#GO:0098609;cellular process#GO:0009987;cellular component assembly#GO:0022607;cell migration#GO:0016477 extrinsic component of membrane#GO:0019898;cell junction#GO:0030054;extrinsic component of plasma membrane#GO:0019897;adherens junction#GO:0005912;anchoring junction#GO:0070161;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane protein complex#GO:0098796;membrane#GO:0016020;cell-cell junction#GO:0005911;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944 cadherin#PC00057;cell adhesion molecule#PC00069 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HUMAN|HGNC=23537|UniProtKB=Q96HY7 Q96HY7 DHTKD1 PTHR23152:SF38 2-OXOGLUTARATE DEHYDROGENASE 2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1 oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the aldehyde or oxo group of donors#GO:0016903 generation of precursor metabolites and energy#GO:0006091;cellular process#GO:0009987;metabolic process#GO:0008152 catalytic complex#GO:1902494;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;transferase complex#GO:1990234;oxidoreductase complex#GO:1990204;membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;protein-containing complex#GO:0032991 oxidoreductase#PC00176;dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=28439|UniProtKB=Q8WUX9 Q8WUX9 CHMP7 PTHR22761:SF21 CHARGED MULTIVESICULAR BODY PROTEIN CHARGED MULTIVESICULAR BODY PROTEIN 7 vesicle budding from membrane#GO:0006900;vesicle organization#GO:0016050;nuclear envelope organization#GO:0006998;endosomal transport#GO:0016197;nucleus organization#GO:0006997;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;transport#GO:0006810;vacuolar transport#GO:0007034;intracellular transport#GO:0046907;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;vesicle-mediated transport#GO:0016192;endosome transport via multivesicular body sorting pathway#GO:0032509;cellular component assembly#GO:0022607;multivesicular body sorting pathway#GO:0071985;late endosome to vacuole transport via multivesicular body sorting pathway#GO:0032511;nuclear membrane organization#GO:0071763;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular localization#GO:0051641;localization#GO:0051179;late endosome to vacuole transport#GO:0045324;membrane assembly#GO:0071709;cellular component organization#GO:0016043 protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;late endosome#GO:0005770;endomembrane system#GO:0012505;plasma membrane#GO:0005886;nuclear envelope#GO:0005635;cytoplasm#GO:0005737;vesicle membrane#GO:0012506;membrane#GO:0016020;nucleus#GO:0005634;cell periphery#GO:0071944;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;cytoplasmic side of membrane#GO:0098562;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;cytoplasmic side of plasma membrane#GO:0009898;vesicle#GO:0031982;side of membrane#GO:0098552;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768;endosome membrane#GO:0010008 membrane traffic protein#PC00150 HUMAN|HGNC=28310|UniProtKB=Q6JBY9 Q6JBY9 RCSD1 PTHR21669:SF2 CAPZ-INTERACTING PROTEIN AND RELATED PROTEINS CAPZ-INTERACTING PROTEIN actin binding#GO:0003779;actin filament binding#GO:0051015;binding#GO:0005488;protein-containing complex binding#GO:0044877;lipid binding#GO:0008289;protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;phospholipid binding#GO:0005543;phosphatidylinositol phosphate binding#GO:1901981 retrograde transport, endosome to Golgi#GO:0042147;macromolecule localization#GO:0033036;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;protein localization to organelle#GO:0033365;cytosolic transport#GO:0016482;intracellular transport#GO:0046907;transport#GO:0006810;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;endosomal transport#GO:0016197;intracellular protein localization#GO:0008104 membrane-bounded organelle#GO:0043227;early endosome#GO:0005769;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular vesicle#GO:0097708;vesicle#GO:0031982 scaffold/adaptor protein#PC00226 HUMAN|HGNC=27035|UniProtKB=Q14CS0 Q14CS0 UBXN2B PTHR23333:SF14 UBX DOMAIN CONTAINING PROTEIN UBX DOMAIN-CONTAINING PROTEIN 2B ubiquitin binding#GO:0043130;binding#GO:0005488;protein binding#GO:0005515 cellular component organization or biogenesis#GO:0071840;establishment of spindle orientation#GO:0051294;microtubule-based process#GO:0007017;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;cytoskeleton organization#GO:0007010;regulation of cell cycle process#GO:0010564;positive regulation of cell cycle#GO:0045787;proteasomal protein catabolic process#GO:0010498;organelle organization#GO:0006996;establishment of mitotic spindle localization#GO:0040001;establishment of localization in cell#GO:0051649;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;cellular localization#GO:0051641;spindle localization#GO:0051653;establishment or maintenance of cell polarity#GO:0007163;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;establishment of organelle localization#GO:0051656;regulation of cell cycle#GO:0051726;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;positive regulation of cell cycle process#GO:0090068;cell cycle process#GO:0022402;macromolecule metabolic process#GO:0043170;establishment of mitotic spindle orientation#GO:0000132;establishment of localization#GO:0051234;mitotic cell cycle process#GO:1903047;ubiquitin-dependent protein catabolic process#GO:0006511;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;biological regulation#GO:0065007;establishment of spindle localization#GO:0051293;positive regulation of cellular process#GO:0048522;localization#GO:0051179;protein metabolic process#GO:0019538;microtubule cytoskeleton organization#GO:0000226;organelle localization#GO:0051640;catabolic process#GO:0009056;mitotic cell cycle#GO:0000278;regulation of cellular process#GO:0050794;cell cycle#GO:0007049;primary metabolic process#GO:0044238;microtubule cytoskeleton organization involved in mitosis#GO:1902850;establishment of cell polarity#GO:0030010;modification-dependent protein catabolic process#GO:0019941 catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ATPase complex#GO:1904949;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 protein-binding activity modulator#PC00095 HUMAN|HGNC=5825|UniProtKB=A0A0C4DH25 A0A0C4DH25 IGKV3D-20 PTHR23267:SF472 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN KAPPA VARIABLE 3-20-RELATED response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 protein-containing complex#GO:0032991 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=16371|UniProtKB=Q96L46 Q96L46 CAPNS2 PTHR46735:SF4 CALPAIN, SMALL SUBUNIT 1 A-RELATED CALPAIN SMALL SUBUNIT 2 intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;endopeptidase complex#GO:1905369;cytoplasm#GO:0005737;caspase complex#GO:0008303;peptidase complex#GO:1905368;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 Huntington disease#P00029>Calpain#P00788 HUMAN|HGNC=28857|UniProtKB=O95780 O95780 ZNF682 PTHR24384:SF116 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED ZINC FINGER PROTEIN 682 double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA-binding transcription factor#PC00218 HUMAN|HGNC=13109|UniProtKB=P17038 P17038 ZNF43 PTHR24376:SF154 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 208-RELATED gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HUMAN|HGNC=20583|UniProtKB=Q86W10 Q86W10 CYP4Z1 PTHR24291:SF63 CYTOCHROME P450 FAMILY 4 CYTOCHROME P450 4X1-RELATED oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262;oxygenase#PC00177 HUMAN|HGNC=7703|UniProtKB=O95169 O95169 NDUFB8 PTHR12840:SF2 NADH-UBIQUINONE OXIDOREDUCTASE ASHI SUBUNIT NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 8, MITOCHONDRIAL transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;catalytic complex#GO:1902494;respiratory chain complex I#GO:0045271;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;respiratory chain complex#GO:0098803;membrane protein complex#GO:0098796;oxidoreductase complex#GO:1990204;membrane#GO:0016020 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HUMAN|HGNC=11205|UniProtKB=P08047 P08047 SP1 PTHR23235:SF16 KRUEPPEL-LIKE TRANSCRIPTION FACTOR TRANSCRIPTION FACTOR SP1 RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 C2H2 zinc finger transcription factor#PC00248 Huntington disease#P00029>Sp1#P00803;Gonadotropin-releasing hormone receptor pathway#P06664>SP1#P06846;CCKR signaling map#P06959>SP1#P07203 HUMAN|HGNC=10349|UniProtKB=P63173 P63173 RPL38 PTHR10965:SF0 60S RIBOSOMAL PROTEIN L38 LARGE RIBOSOMAL SUBUNIT PROTEIN EL38 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;cytoplasmic translation#GO:0002181;translation#GO:0006412;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 intracellular organelle#GO:0043229;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;ribosome#GO:0005840;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625;cytosol#GO:0005829;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226 ribosomal protein#PC00202;translational protein#PC00263 HUMAN|HGNC=19141|UniProtKB=Q6IQ55 Q6IQ55 TTBK2 PTHR11909:SF451 CASEIN KINASE-RELATED TAU-TUBULIN KINASE 2 protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cell projection assembly#GO:0030031;signal transduction#GO:0007165;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection assembly#GO:0120031;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cell projection organization#GO:0030030;signaling#GO:0023052;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cell communication#GO:0007154;cilium organization#GO:0044782;organelle assembly#GO:0070925 intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cilium#GO:0005929;intracellular organelle#GO:0043229;ciliary transition zone#GO:0035869;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;nucleus#GO:0005634;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;ciliary basal body#GO:0036064;microtubule organizing center#GO:0005815 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=18800|UniProtKB=Q9P215 Q9P215 POGK PTHR19303:SF57 TRANSPOSON POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN nucleic acid binding#GO:0003676;binding#GO:0005488;DNA binding#GO:0003677 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 viral or transposable element protein#PC00237 HUMAN|HGNC=12127|UniProtKB=P04437 P04437 TRAV29DV5 PTHR19343:SF24 T CELL RECEPTOR ALPHA VARIABLE 1-2 T CELL RECEPTOR ALPHA VARIABLE 29_DELTA VARIABLE 5 binding#GO:0005488;antigen binding#GO:0003823;peptide binding#GO:0042277 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=13273|UniProtKB=Q9NRD8 Q9NRD8 DUOX2 PTHR11972:SF67 NADPH OXIDASE DUAL OXIDASE 2 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor#GO:0050664;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on NAD(P)H#GO:0016651 metabolic process#GO:0008152;reactive oxygen species metabolic process#GO:0072593;response to stress#GO:0006950;cellular process#GO:0009987;superoxide metabolic process#GO:0006801;response to stimulus#GO:0050896;defense response#GO:0006952 membrane protein complex#GO:0098796;oxidoreductase complex#GO:1990204;membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;catalytic complex#GO:1902494 metabolite interconversion enzyme#PC00262;oxidase#PC00175 HUMAN|HGNC=20427|UniProtKB=Q9NS73 Q9NS73 MBIP PTHR23404:SF3 MOLYBDOPTERIN SYNTHASE RELATED MAP3K12-BINDING INHIBITORY PROTEIN 1 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=30796|UniProtKB=Q9Y3F4 Q9Y3F4 STRAP PTHR19877:SF19 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I SERINE-THREONINE KINASE RECEPTOR-ASSOCIATED PROTEIN RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 cellular component assembly#GO:0022607;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;mRNA processing#GO:0006397;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-RNA complex organization#GO:0071826;protein-containing complex organization#GO:0043933;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;spliceosomal snRNP assembly#GO:0000387;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;protein-containing complex assembly#GO:0065003;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;protein-RNA complex assembly#GO:0022618;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;Sm-like protein family complex#GO:0120114;SMN-Sm protein complex#GO:0034719;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;SMN complex#GO:0032797 translation initiation factor#PC00224;translation factor#PC00223 HUMAN|HGNC=9596|UniProtKB=P35408 P35408 PTGER4 PTHR11866:SF6 G-PROTEIN COUPLED RECEPTOR FAMILY 1 MEMBER PROSTAGLANDIN E2 RECEPTOR EP4 SUBTYPE signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;regulation of inflammatory response#GO:0050727;regulation of defense response#GO:0031347;negative regulation of defense response#GO:0031348;negative regulation of inflammatory response#GO:0050728;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;cellular response to alcohol#GO:0097306;regulation of response to stress#GO:0080134;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;regulation of response to stimulus#GO:0048583;negative regulation of response to stimulus#GO:0048585;biological regulation#GO:0065007;regulation of biological quality#GO:0065008;cellular response to chemical stimulus#GO:0070887;positive regulation of cytosolic calcium ion concentration#GO:0007204;G protein-coupled receptor signaling pathway#GO:0007186;response to oxygen-containing compound#GO:1901700;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;response to alcohol#GO:0097305;cellular response to hormone stimulus#GO:0032870;signaling#GO:0023052;response to endogenous stimulus#GO:0009719;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;response to chemical#GO:0042221;response to lipid#GO:0033993;cellular response to lipid#GO:0071396;regulation of response to external stimulus#GO:0032101;negative regulation of response to external stimulus#GO:0032102;response to hormone#GO:0009725;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 Gonadotropin-releasing hormone receptor pathway#P06664>PG Rcs#P06836 HUMAN|HGNC=28592|UniProtKB=Q4G1C9 Q4G1C9 GLIPR1L2 PTHR10334:SF236 CYSTEINE-RICH SECRETORY PROTEIN-RELATED GLIPR1-LIKE PROTEIN 2 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090 HUMAN|HGNC=53437|UniProtKB=A0A1B0GUU1 A0A1B0GUU1 C17orf113 PTHR46880:SF6 RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN ZINC FINGER PROTEIN 385C HUMAN|HGNC=12919|UniProtKB=P52742 P52742 ZNF135 PTHR24377:SF1029 IP01015P-RELATED ZINC FINGER PROTEIN 135 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=30672|UniProtKB=Q8N3V7 Q8N3V7 SYNPO PTHR24217:SF13 PUTATIVE-RELATED SYNAPTOPODIN cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;binding#GO:0005488;protein binding#GO:0005515 striated muscle cell development#GO:0055002;positive regulation of organelle organization#GO:0010638;animal gross anatomical part developmental process#GO:0160108;regulation of intracellular signal transduction#GO:1902531;positive regulation of cellular component organization#GO:0051130;regulation of signaling#GO:0023051;regulation of cellular component organization#GO:0051128;cell differentiation#GO:0030154;regulation of Rho protein signal transduction#GO:0035023;actomyosin structure organization#GO:0031032;regulation of cellular component biogenesis#GO:0044087;cell development#GO:0048468;regulation of actin filament bundle assembly#GO:0032231;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;cellular component organization or biogenesis#GO:0071840;regulation of small GTPase mediated signal transduction#GO:0051056;striated muscle cell differentiation#GO:0051146;anatomical structure formation involved in morphogenesis#GO:0048646;cellular anatomical entity morphogenesis#GO:0032989;cellular component assembly#GO:0022607;positive regulation of cellular component biogenesis#GO:0044089;cytoskeleton organization#GO:0007010;regulation of actin cytoskeleton organization#GO:0032956;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;organelle assembly#GO:0070925;cellular component assembly involved in morphogenesis#GO:0010927;sarcomere organization#GO:0045214;actin filament-based process#GO:0030029;regulation of cytoskeleton organization#GO:0051493;actin cytoskeleton organization#GO:0030036;muscle structure development#GO:0061061;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;muscle cell development#GO:0055001;regulation of supramolecular fiber organization#GO:1902903;myofibril assembly#GO:0030239;muscle cell differentiation#GO:0042692;cellular developmental process#GO:0048869;positive regulation of actin filament bundle assembly#GO:0032233;regulation of actin filament-based process#GO:0032970;developmental process#GO:0032502;regulation of response to stimulus#GO:0048583;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of cellular process#GO:0048522;regulation of actin filament organization#GO:0110053 Z disc#GO:0030018;contractile muscle fiber#GO:0043292;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;glutamatergic synapse#GO:0098978;neuron to neuron synapse#GO:0098984;supramolecular polymer#GO:0099081;postsynaptic specialization#GO:0099572;supramolecular complex#GO:0099080;I band#GO:0031674;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;sarcomere#GO:0030017;cell junction#GO:0030054;postsynapse#GO:0098794;actin cytoskeleton#GO:0015629;cellular anatomical structure#GO:0110165;synapse#GO:0045202;asymmetric synapse#GO:0032279;organelle#GO:0043226;postsynaptic density#GO:0014069;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;myofibril#GO:0030016 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=6473|UniProtKB=P51826 P51826 AFF3 PTHR10528:SF16 AF4/FMR2 FAMILY MEMBER AF4_FMR2 FAMILY MEMBER 3 transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of biological process#GO:0050789;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;nervous system process#GO:0050877;nucleic acid biosynthetic process#GO:0141187;regulation of RNA metabolic process#GO:0051252;RNA metabolic process#GO:0016070;regulation of DNA-templated transcription#GO:0006355;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;DNA-templated transcription elongation#GO:0006354;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;biosynthetic process#GO:0009058;multicellular organismal process#GO:0032501;gene expression#GO:0010467;regulation of nucleobase-containing compound metabolic process#GO:0019219;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;regulation of gene expression#GO:0010468;system process#GO:0003008;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;transcription elongation factor complex#GO:0008023;protein-containing complex#GO:0032991;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=9779|UniProtKB=O95716 O95716 RAB3D PTHR47980:SF17 LD44762P RAS-RELATED PROTEIN RAB-3D binding#GO:0005488;myosin binding#GO:0017022;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515 vesicle-mediated transport#GO:0016192;export from cell#GO:0140352;cellular process#GO:0009987;establishment of localization#GO:0051234;secretion#GO:0046903;localization#GO:0051179;exocytosis#GO:0006887;secretion by cell#GO:0032940;transport#GO:0006810 endomembrane system#GO:0012505;transport vesicle#GO:0030133;cytoplasm#GO:0005737;plasma membrane#GO:0005886;membrane#GO:0016020;secretory vesicle#GO:0099503;cell periphery#GO:0071944;presynapse#GO:0098793;cell junction#GO:0030054;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;synaptic vesicle#GO:0008021;vesicle#GO:0031982;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229 HUMAN|HGNC=53905|UniProtKB=A0A2R8Y4Y8 A0A2R8Y4Y8 OOSP4B PTHR14380:SF9 PLACENTA-SPECIFIC PROTEIN 1 OOCYTE-SECRETED PROTEIN 4B HUMAN|HGNC=1036|UniProtKB=Q9HBH7 Q9HBH7 BEX1 PTHR19430:SF3 PROTEIN BEX1-RELATED PROTEIN BEX1 protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=721|UniProtKB=P54793 P54793 ARSF PTHR42693:SF2 ARYLSULFATASE FAMILY MEMBER ARYLSULFATASE F catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787 hydrolase#PC00121 HUMAN|HGNC=3368|UniProtKB=O75354 O75354 ENTPD6 PTHR11782:SF99 ADENOSINE/GUANOSINE DIPHOSPHATASE ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 6 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;nucleoside diphosphate phosphatase activity#GO:0017110;ribonucleoside triphosphate phosphatase activity#GO:0017111 phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;nucleobase-containing compound catabolic process#GO:0034655;organophosphate metabolic process#GO:0019637;nucleoside diphosphate catabolic process#GO:0009134;cellular process#GO:0009987;nucleoside phosphate catabolic process#GO:1901292;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;nucleoside diphosphate metabolic process#GO:0009132;organophosphate catabolic process#GO:0046434;nucleobase-containing small molecule metabolic process#GO:0055086 membrane#GO:0016020;cell periphery#GO:0071944;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;plasma membrane#GO:0005886;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 hydrolase#PC00121;nucleotide phosphatase#PC00173;phosphatase#PC00181 HUMAN|HGNC=25808|UniProtKB=Q3B820 Q3B820 FAM161A PTHR21501:SF3 PROTEIN FAM-161 PROTEIN FAM161A plasma membrane bounded cell projection organization#GO:0120036;cilium organization#GO:0044782;cell projection organization#GO:0030030;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996 cilium#GO:0005929;ciliary transition zone#GO:0035869;membrane-bounded organelle#GO:0043227;non-motile cilium#GO:0097730;neuron projection#GO:0043005;photoreceptor cell cilium#GO:0097733;9+0 non-motile cilium#GO:0097731;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=4387|UniProtKB=P08754 P08754 GNAI3 PTHR10218:SF230 GTP-BINDING PROTEIN ALPHA SUBUNIT GUANINE NUCLEOTIDE-BINDING PROTEIN G(I) SUBUNIT ALPHA-3 molecular function regulator activity#GO:0098772;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 extrinsic component of cytoplasmic side of plasma membrane#GO:0031234;catalytic complex#GO:1902494;side of membrane#GO:0098552;intracellular anatomical structure#GO:0005622;cytoplasmic side of plasma membrane#GO:0009898;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cellular anatomical structure#GO:0110165;cytoplasmic side of membrane#GO:0098562;extrinsic component of plasma membrane#GO:0019897;extrinsic component of membrane#GO:0019898;membrane#GO:0016020;cell periphery#GO:0071944;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;plasma membrane#GO:0005886 heterotrimeric G-protein#PC00117;G-protein#PC00020 Metabotropic glutamate receptor group III pathway#P00039>G-Protein#P01045;Opioid proopiomelanocortin pathway#P05917>G-protein#P06012;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>G-Protein#P01085;Enkephalin release#P05913>G-Protein (i)#P05974;Gonadotropin-releasing hormone receptor pathway#P06664>gnai#P06807;PI3 kinase pathway#P00048>Galpha#P01199;Endogenous cannabinoid signaling#P05730>Galpha#P05751;Opioid proenkephalin pathway#P05915>G-protein#P05994;5HT1 type receptor mediated signaling pathway#P04373>G-protein#P04408;Dopamine receptor mediated signaling pathway#P05912>Gialpha#P05958;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Galphai/q#P00873;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Gialpha#P00712;Opioid prodynorphin pathway#P05916>G-protein#P06002;Metabotropic glutamate receptor group II pathway#P00040>G-protein#P01047;GABA-B receptor II signaling#P05731>Gi/oalpha#P05757;Nicotine pharmacodynamics pathway#P06587>GNAI#P06609;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Galphai#P00828 HUMAN|HGNC=15569|UniProtKB=O75952 O75952 CABYR PTHR15494:SF0 CALCIUM-BINDING TYROSINE PHOSPHORYLATION-REGULATED PROTEIN CALCIUM-BINDING TYROSINE PHOSPHORYLATION-REGULATED PROTEIN binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;calcium ion binding#GO:0005509;metal ion binding#GO:0046872;cation binding#GO:0043169 organelle#GO:0043226;motile cilium#GO:0031514;sperm flagellum#GO:0036126;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;cilium#GO:0005929;9+2 motile cilium#GO:0097729;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=17210|UniProtKB=Q8IY37 Q8IY37 DHX37 PTHR18934:SF99 ATP-DEPENDENT RNA HELICASE ATP-DEPENDENT RNA HELICASE DHX37-RELATED isomerase activity#GO:0016853;helicase activity#GO:0004386;macromolecular conformation isomerase activity#GO:0120543;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity#GO:0003824;RNA binding#GO:0003723;ATP-dependent activity#GO:0140657;binding#GO:0005488;nucleic acid binding#GO:0003676 cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;ribosomal small subunit biogenesis#GO:0042274;metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;maturation of SSU-rRNA#GO:0030490;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228 RNA metabolism protein#PC00031;RNA helicase#PC00032 HUMAN|HGNC=26332|UniProtKB=Q569K4 Q569K4 ZNF385B PTHR23067:SF8 DOUBLE-STRANDED RNA-BINDING ZINC FINGER PROTEIN ZINC FINGER PROTEIN 385B cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=13432|UniProtKB=Q9NV58 Q9NV58 RNF19A PTHR11685:SF111 RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING E3 UBIQUITIN-PROTEIN LIGASE RNF19A ubiquitin-like protein transferase activity#GO:0019787;enzyme binding#GO:0019899;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;binding#GO:0005488;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;protein binding#GO:0005515;transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;catabolic process#GO:0009056;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;ubiquitin ligase complex#GO:0000151;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;transferase complex#GO:1990234 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=24626|UniProtKB=O95881 O95881 TXNDC12 PTHR15337:SF10 ANTERIOR GRADIENT PROTEIN-RELATED THIOREDOXIN DOMAIN-CONTAINING PROTEIN 12 catalytic activity#GO:0003824;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;protein-disulfide reductase activity#GO:0015035;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491;disulfide oxidoreductase activity#GO:0015036 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;endoplasmic reticulum lumen#GO:0005788;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 reductase#PC00198;oxidoreductase#PC00176 HUMAN|HGNC=32265|UniProtKB=P0DV74 P0DV74 FAM90A17 PTHR16035:SF14 PROTEIN FAM90A1 PROTEIN FAM90A10-RELATED HUMAN|HGNC=6657|UniProtKB=Q8TBB1 Q8TBB1 LNX1 PTHR19964:SF14 MULTIPLE PDZ DOMAIN PROTEIN E3 UBIQUITIN-PROTEIN LIGASE LNX catalytic activity, acting on a protein#GO:0140096;ubiquitin-protein transferase activity#GO:0004842;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787 modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;catabolic process#GO:0009056 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 Notch signaling pathway#P00045>LNXp80#P01111 HUMAN|HGNC=37156|UniProtKB=P0CJ69 P0CJ69 MTRNR2L2 PTHR33895:SF18 HUMANIN-LIKE 4 HUMANIN-LIKE 1-RELATED signaling receptor regulator activity#GO:0030545;signaling receptor inhibitor activity#GO:0030547;molecular function inhibitor activity#GO:0140678;molecular function regulator activity#GO:0098772 negative regulation of cellular process#GO:0048523;regulation of apoptotic process#GO:0042981;regulation of cellular process#GO:0050794;negative regulation of apoptotic process#GO:0043066;biological regulation#GO:0065007;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of programmed cell death#GO:0043069 HUMAN|HGNC=24961|UniProtKB=Q9BPY8 Q9BPY8 HOPX PTHR21408:SF1 HOMEODOMAIN-ONLY PROTEIN HOMEODOMAIN-ONLY PROTEIN enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;circulatory system development#GO:0072359;animal gross anatomical part developmental process#GO:0160108;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;multicellular organismal process#GO:0032501;heart development#GO:0007507;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;developmental process#GO:0032502;animal organ development#GO:0048513;regulation of biosynthetic process#GO:0009889;multicellular organism development#GO:0007275;regulation of gene expression#GO:0010468 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 HUMAN|HGNC=27320|UniProtKB=Q504U0 Q504U0 C4orf46 PTHR31641:SF2 RENAL CANCER DIFFERENTIATION GENE 1 PROTEIN RENAL CANCER DIFFERENTIATION GENE 1 PROTEIN HUMAN|HGNC=32958|UniProtKB=A6NEL2 A6NEL2 SOWAHB PTHR14491:SF3 SOSONDOWAH, ISOFORM G ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN SOWAHB HUMAN|HGNC=17806|UniProtKB=P0DTL6 P0DTL6 ZFTRAF1 PTHR23059:SF4 CYSTEINE AND HISTIDINE-RICH PROTEIN 1 ZINC FINGER TRAF-TYPE-CONTAINING PROTEIN 1 HUMAN|HGNC=21250|UniProtKB=Q6UWE3 Q6UWE3 CLPSL2 PTHR10041:SF3 COLIPASE COLIPASE-LIKE PROTEIN 2 enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme activator activity#GO:0008047 protein-binding activity modulator#PC00095 HUMAN|HGNC=8830|UniProtKB=Q9UBM1 Q9UBM1 PEMT PTHR15458:SF5 PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE N-methyltransferase activity#GO:0008170;transferase activity#GO:0016740;catalytic activity#GO:0003824;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741 organophosphate biosynthetic process#GO:0090407;glycerolipid metabolic process#GO:0046486;phospholipid biosynthetic process#GO:0008654;phospholipid metabolic process#GO:0006644;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;metabolic process#GO:0008152;glycerophospholipid biosynthetic process#GO:0046474;lipid metabolic process#GO:0006629;phosphatidylcholine metabolic process#GO:0046470;glycerophospholipid metabolic process#GO:0006650;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058;phosphatidylcholine biosynthetic process#GO:0006656;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 metabolite interconversion enzyme#PC00262;methyltransferase#PC00155 HUMAN|HGNC=5924|UniProtKB=A0A087WSX0 A0A087WSX0 IGLV5-45 PTHR23267:SF325 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN LAMBDA VARIABLE 5-37-RELATED response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=44317|UniProtKB=Q96I23 Q96I23 PYURF PTHR33505:SF7 ZGC:162634 PROTEIN PREY, MITOCHONDRIAL HUMAN|HGNC=14263|UniProtKB=Q9ULC3 Q9ULC3 RAB23 PTHR24073:SF209 DRAB5-RELATED RAS-RELATED PROTEIN RAB-23 ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462 intracellular transport#GO:0046907;metabolic process#GO:0008152;transport#GO:0006810;intracellular protein transport#GO:0006886;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;autophagosome assembly#GO:0000045;intracellular protein localization#GO:0008104;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;macromolecule localization#GO:0033036;autophagosome organization#GO:1905037;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;autophagy#GO:0006914;cellular component assembly#GO:0022607;macroautophagy#GO:0016236;organelle assembly#GO:0070925;cellular localization#GO:0051641;localization#GO:0051179;protein transport#GO:0015031;process utilizing autophagic mechanism#GO:0061919;vacuole organization#GO:0007033;cellular component organization#GO:0016043;catabolic process#GO:0009056 intracellular organelle#GO:0043229;endosome#GO:0005768;endosome membrane#GO:0010008;autophagosome#GO:0005776;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;cell periphery#GO:0071944;vesicle membrane#GO:0012506;membrane#GO:0016020;vacuole#GO:0005773;plasma membrane#GO:0005886;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659 G-protein#PC00020;small GTPase#PC00208 HUMAN|HGNC=17748|UniProtKB=Q9NYF0 Q9NYF0 DACT1 PTHR15919:SF12 DAPPER-RELATED DAPPER HOMOLOG 1 negative regulation of biological process#GO:0048519;negative regulation of MAPK cascade#GO:0043409;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of Wnt signaling pathway#GO:0030111;regulation of cell communication#GO:0010646;regulation of intracellular signal transduction#GO:1902531;negative regulation of canonical Wnt signaling pathway#GO:0090090;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;regulation of canonical Wnt signaling pathway#GO:0060828;negative regulation of response to stimulus#GO:0048585;negative regulation of Wnt signaling pathway#GO:0030178;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of MAPK cascade#GO:0043408;regulation of JNK cascade#GO:0046328 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 Wnt signaling pathway#P00057>Frodo#P01470;Wnt signaling pathway#P00057>Dapper#P01469 HUMAN|HGNC=32687|UniProtKB=Q9P086 Q9P086 MED11 PTHR22890:SF2 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 11 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 11 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mediator complex#GO:0016592;nuclear protein-containing complex#GO:0140513 HUMAN|HGNC=28571|UniProtKB=Q8IV50 Q8IV50 LYSMD2 PTHR20932:SF4 LYSM AND PUTATIVE PEPTIDOGLYCAN-BINDING DOMAIN-CONTAINING PROTEIN AND PUTATIVE PEPTIDOGLYCAN-BINDING DOMAIN-CONTAINING PROTEIN 2-RELATED HUMAN|HGNC=18219|UniProtKB=Q9HCU0 Q9HCU0 CD248 PTHR14789:SF4 CHONDROLECTIN VARIANT CHODLFDELTAE. ENDOSIALIN extracellular matrix binding#GO:0050840;protein binding#GO:0005515;binding#GO:0005488 cellular process#GO:0009987;cell migration#GO:0016477;cell motility#GO:0048870 plasma membrane#GO:0005886;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020 HUMAN|HGNC=23624|UniProtKB=Q8TDV0 Q8TDV0 GPR151 PTHR45695:SF1 LEUCOKININ RECEPTOR-RELATED G PROTEIN-COUPLED RECEPTOR 151 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=4810|UniProtKB=Q9NYQ3 Q9NYQ3 HAO2 PTHR10578:SF149 S -2-HYDROXY-ACID OXIDASE-RELATED 2-HYDROXYACID OXIDASE 2 catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614 cellular process#GO:0009987;reactive oxygen species metabolic process#GO:0072593;metabolic process#GO:0008152;hydrogen peroxide metabolic process#GO:0042743;biosynthetic process#GO:0009058 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;peroxisomal matrix#GO:0005782;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;peroxisome#GO:0005777;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;microbody#GO:0042579 oxidoreductase#PC00176 HUMAN|HGNC=7876|UniProtKB=P29474 P29474 NOS3 PTHR19384:SF66 NITRIC OXIDE SYNTHASE-RELATED NITRIC OXIDE SYNTHASE 3 ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen#GO:0016709;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;oxidoreductase activity#GO:0016491;nucleotide binding#GO:0000166;nucleoside phosphate binding#GO:1901265;flavin adenine dinucleotide binding#GO:0050660;binding#GO:0005488;oxidoreductase activity, acting on NAD(P)H#GO:0016651;monooxygenase activity#GO:0004497;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;heterocyclic compound binding#GO:1901363 regulation of biological process#GO:0050789;response to molecule of bacterial origin#GO:0002237;carboxylic acid metabolic process#GO:0019752;response to endogenous stimulus#GO:0009719;small molecule catabolic process#GO:0044282;biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052;response to stimulus#GO:0050896;small molecule metabolic process#GO:0044281;response to oxygen-containing compound#GO:1901700;oxoacid metabolic process#GO:0043436;regulation of biological quality#GO:0065008;cellular process#GO:0009987;signal transduction#GO:0007165;response to hormone#GO:0009725;response to biotic stimulus#GO:0009607;intracellular signaling cassette#GO:0141124;arginine metabolic process#GO:0006525;response to lipid#GO:0033993;response to chemical#GO:0042221;metabolic process#GO:0008152;response to lipopolysaccharide#GO:0032496;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;response to external biotic stimulus#GO:0043207;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;circulatory system process#GO:0003013;response to bacterium#GO:0009617;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;carboxylic acid catabolic process#GO:0046395;regulation of blood pressure#GO:0008217;amino acid metabolic process#GO:0006520;response to other organism#GO:0051707;biological regulation#GO:0065007;biosynthetic process#GO:0009058;multicellular organismal process#GO:0032501;proteinogenic amino acid metabolic process#GO:0170039;blood circulation#GO:0008015;system process#GO:0003008;response to external stimulus#GO:0009605 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;plasma membrane#GO:0005886;membrane#GO:0016020;cytosol#GO:0005829;cell periphery#GO:0071944;nucleus#GO:0005634 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 Angiogenesis#P00005>eNOS#P00210;Endothelin signaling pathway#P00019>eNOS#P00578;PI3 kinase pathway#P00048>NOS#P01205;VEGF signaling pathway#P00056>eNOS#P01422;Interleukin signaling pathway#P00036>eNOS#P00986 HUMAN|HGNC=27309|UniProtKB=Q86XF0 Q86XF0 DHFR2 PTHR48069:SF1 DIHYDROFOLATE REDUCTASE DIHYDROFOLATE REDUCTASE 2, MITOCHONDRIAL heterocyclic compound binding#GO:1901363;oxidoreductase activity#GO:0016491;nucleotide binding#GO:0000166;purine nucleotide binding#GO:0017076;catalytic activity#GO:0003824;nucleoside phosphate binding#GO:1901265;small molecule binding#GO:0036094;binding#GO:0005488 cellular process#GO:0009987;carboxylic acid metabolic process#GO:0019752;modified amino acid metabolic process#GO:0006575;biosynthetic process#GO:0009058;folic acid-containing compound metabolic process#GO:0006760;pteridine-containing compound metabolic process#GO:0042558;small molecule metabolic process#GO:0044281;tetrahydrofolate biosynthetic process#GO:0046654;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;tetrahydrofolate metabolic process#GO:0046653 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 reductase#PC00198;oxidoreductase#PC00176 Tetrahydrofolate biosynthesis#P02742>Dihydrofolate reductase#P02948;Tetrahydrofolate biosynthesis#P02742>Dihydrofolate synthase#P02943;Formyltetrahydrofolate biosynthesis#P02743>Dihydrofolate reductase#P02957 HUMAN|HGNC=4427|UniProtKB=Q13439 Q13439 GOLGA4 PTHR19327:SF0 GOLGIN GOLGIN SUBFAMILY A MEMBER 4 small GTPase binding#GO:0031267;protein binding#GO:0005515;binding#GO:0005488;enzyme binding#GO:0019899 cellular process#GO:0009987;Golgi vesicle transport#GO:0048193;transport#GO:0006810;localization#GO:0051179;vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226 membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=3249|UniProtKB=P41567 P41567 EIF1 PTHR10388:SF10 EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1 EUKARYOTIC TRANSLATION INITIATION FACTOR 1 ribosome binding#GO:0043022;protein-containing complex binding#GO:0044877;RNA binding#GO:0003723;ribonucleoprotein complex binding#GO:0043021;nucleic acid binding#GO:0003676;binding#GO:0005488;translation initiation factor activity#GO:0003743;translation factor activity#GO:0180051 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904 translation initiation factor#PC00224 HUMAN|HGNC=13884|UniProtKB=Q9H172 Q9H172 ABCG4 PTHR48041:SF75 ABC TRANSPORTER G FAMILY MEMBER 28 ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 4 active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399;transporter activity#GO:0005215;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657;transmembrane transporter activity#GO:0022857 cholesterol homeostasis#GO:0042632;sterol transport#GO:0015918;establishment of localization#GO:0051234;chemical homeostasis#GO:0048878;transport#GO:0006810;lipid transport#GO:0006869;cholesterol transport#GO:0030301;macromolecule localization#GO:0033036;cellular process#GO:0009987;cholesterol efflux#GO:0033344;transmembrane transport#GO:0055085;localization#GO:0051179;organic hydroxy compound transport#GO:0015850;lipid localization#GO:0010876;homeostatic process#GO:0042592;lipid homeostasis#GO:0055088 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227;primary active transporter#PC00068;ATP-binding cassette (ABC) transporter#PC00003 HUMAN|HGNC=9158|UniProtKB=Q8ND90 Q8ND90 PNMA1 PTHR23095:SF17 PARANEOPLASTIC ANTIGEN PARANEOPLASTIC ANTIGEN MA1 transcription cofactor#PC00217 HUMAN|HGNC=16369|UniProtKB=Q99497 Q99497 PARK7 PTHR48094:SF16 PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED PARKINSON DISEASE PROTEIN 7 hydro-lyase activity#GO:0016836;oxidoreductase activity, acting on peroxide as acceptor#GO:0016684;lyase activity#GO:0016829;carbon-oxygen lyase activity#GO:0016835;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 response to chemical#GO:0042221;detoxification#GO:0098754;biosynthetic process#GO:0009058;cellular response to toxic substance#GO:0097237;aldehyde catabolic process#GO:0046185;response to stress#GO:0006950;alcohol biosynthetic process#GO:0046165;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987;aldehyde metabolic process#GO:0006081;response to oxidative stress#GO:0006979;monocarboxylic acid biosynthetic process#GO:0072330;metabolic process#GO:0008152;alcohol metabolic process#GO:0006066;small molecule biosynthetic process#GO:0044283;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;response to toxic substance#GO:0009636;small molecule catabolic process#GO:0044282;cellular detoxification of aldehyde#GO:0110095;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;ketone metabolic process#GO:0042180;carboxylic acid biosynthetic process#GO:0046394;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;oxoacid metabolic process#GO:0043436;response to oxygen-containing compound#GO:1901700;cellular detoxification#GO:1990748 mitochondrion#GO:0005739;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=9861|UniProtKB=P10114 P10114 RAP2A PTHR24070:SF221 RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY RAS-RELATED PROTEIN RAP-2A GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111 negative regulation of cellular process#GO:0048523;negative regulation of cell migration#GO:0030336;regulation of cell migration#GO:0030334;intracellular signaling cassette#GO:0141124;regulation of locomotion#GO:0040012;negative regulation of cell motility#GO:2000146;negative regulation of locomotion#GO:0040013;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of cell motility#GO:2000145;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;negative regulation of biological process#GO:0048519;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 small GTPase#PC00208 Integrin signalling pathway#P00034>Rap1#P00906 HUMAN|HGNC=2051|UniProtKB=O95484 O95484 CLDN9 PTHR12002:SF42 CLAUDIN CLAUDIN-9 virus receptor activity#GO:0001618;protein binding#GO:0005515;binding#GO:0005488 cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;cell junction assembly#GO:0034329;cellular process#GO:0009987;cell junction organization#GO:0034330;cellular component assembly#GO:0022607;cell-cell junction assembly#GO:0007043;cell-cell junction organization#GO:0045216;cellular component organization or biogenesis#GO:0071840 cell periphery#GO:0071944;membrane#GO:0016020;cell-cell junction#GO:0005911;plasma membrane#GO:0005886;bicellular tight junction#GO:0005923;cellular anatomical structure#GO:0110165;apical junction complex#GO:0043296;anchoring junction#GO:0070161;cell junction#GO:0030054;tight junction#GO:0070160 tight junction#PC00214;cell junction protein#PC00070 HUMAN|HGNC=15475|UniProtKB=Q9BQR3 Q9BQR3 PRSS27 PTHR24253:SF144 TRANSMEMBRANE PROTEASE SERINE SERINE PROTEASE 27 peptidase activity#GO:0008233;serine hydrolase activity#GO:0017171;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;serine-type peptidase activity#GO:0008236 primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;protein processing#GO:0016485;cellular process#GO:0009987;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;metabolic process#GO:0008152;proteolysis#GO:0006508;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 serine protease#PC00203;protease#PC00190;protein modifying enzyme#PC00260 HUMAN|HGNC=16272|UniProtKB=Q96JK9 Q96JK9 MAML3 PTHR15692:SF8 MASTERMIND-LIKE MASTERMIND-LIKE PROTEIN 3 transcription coactivator activity#GO:0003713;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 cell surface receptor signaling pathway#GO:0007166;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of macromolecule metabolic process#GO:0010604;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;Notch signaling pathway#GO:0007219;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA metabolic process#GO:0051252;cell communication#GO:0007154;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HUMAN|HGNC=28322|UniProtKB=Q96C55 Q96C55 ZNF524 PTHR24390:SF109 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 524 binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218 HUMAN|HGNC=15546|UniProtKB=Q96KT7 Q96KT7 SLC35G5 PTHR22911:SF32 ACYL-MALONYL CONDENSING ENZYME-RELATED SOLUTE CARRIER FAMILY 35 MEMBER G4-RELATED cellular anatomical structure#GO:0110165;membrane#GO:0016020 transporter#PC00227 HUMAN|HGNC=18121|UniProtKB=Q9BY79 Q9BY79 MFRP PTHR24251:SF60 OVOCHYMASE-RELATED MEMBRANE FRIZZLED-RELATED PROTEIN serine protease#PC00203;protease#PC00190 HUMAN|HGNC=2356|UniProtKB=P24387 P24387 CRHBP PTHR10278:SF0 CORTICOTROPIN-RELEASING FACTOR-BINDING PROTEIN CORTICOTROPIN-RELEASING HORMONE-BINDING PROTEIN hormone binding#GO:0042562;binding#GO:0005488;peptide hormone binding#GO:0017046 negative regulation of cellular process#GO:0048523;regulation of system process#GO:0044057;biological regulation#GO:0065007;cell communication#GO:0007154;regulation of secretion#GO:0051046;regulation of cellular process#GO:0050794;negative regulation of transport#GO:0051051;regulation of cell communication#GO:0010646;negative regulation of multicellular organismal process#GO:0051241;cellular response to stimulus#GO:0051716;regulation of transport#GO:0051049;regulation of localization#GO:0032879;response to chemical#GO:0042221;regulation of multicellular organismal process#GO:0051239;response to hormone#GO:0009725;cellular process#GO:0009987;signal transduction#GO:0007165;hormone-mediated signaling pathway#GO:0009755;regulation of hormone secretion#GO:0046883;negative regulation of cell communication#GO:0010648;regulation of secretion by cell#GO:1903530;regulation of biological quality#GO:0065008;cellular response to chemical stimulus#GO:0070887;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;cellular response to hormone stimulus#GO:0032870;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;signaling#GO:0023052;response to endogenous stimulus#GO:0009719;negative regulation of biological process#GO:0048519;regulation of hormone levels#GO:0010817;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=6290|UniProtKB=Q92952 Q92952 KCNN1 PTHR10153:SF38 SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL PROTEIN 1 potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;calcium-activated cation channel activity#GO:0005227;ligand-gated monoatomic ion channel activity#GO:0015276;potassium channel activity#GO:0005267;monoatomic cation channel activity#GO:0005261;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;calcium-activated potassium channel activity#GO:0015269;monoatomic ion-gated channel activity#GO:0022839;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;protein binding#GO:0005515;monoatomic cation transmembrane transporter activity#GO:0008324;binding#GO:0005488;gated channel activity#GO:0022836;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873;calmodulin binding#GO:0005516;transporter activity#GO:0005215 cellular process#GO:0009987;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;potassium ion transmembrane transport#GO:0071805;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;transport#GO:0006810;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811 membrane#GO:0016020;cell body#GO:0044297;neuron projection#GO:0043005;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;neuronal cell body#GO:0043025;cell projection#GO:0042995;somatodendritic compartment#GO:0036477;plasma membrane bounded cell projection#GO:0120025 ion channel#PC00133;voltage-gated ion channel#PC00241 HUMAN|HGNC=9086|UniProtKB=P60201 P60201 PLP1 PTHR11683:SF11 MYELIN PROTEOLIPID MYELIN PROTEOLIPID PROTEIN structural molecule activity#GO:0005198 cell development#GO:0048468;cell differentiation#GO:0030154;cell projection organization#GO:0030030;central nervous system development#GO:0007417;cellular component organization#GO:0016043;neuron development#GO:0048666;system development#GO:0048731;anatomical structure development#GO:0048856;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;multicellular organismal process#GO:0032501;glial cell differentiation#GO:0010001;oligodendrocyte differentiation#GO:0048709;cellular process#GO:0009987;axon development#GO:0061564;neuron projection development#GO:0031175;neurogenesis#GO:0022008;myelination#GO:0042552;gliogenesis#GO:0042063;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;developmental process#GO:0032502;neuron differentiation#GO:0030182 cell periphery#GO:0071944;membrane#GO:0016020;myelin sheath#GO:0043209;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 myelin protein#PC00161 HUMAN|HGNC=8965|UniProtKB=Q92643 Q92643 PIGK PTHR48067:SF1 GPI-ANCHOR TRANSAMIDASE GPI-ANCHOR TRANSAMIDASE cysteine-type peptidase activity#GO:0008234;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;cysteine-type endopeptidase activity#GO:0004197;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;hydrolase activity#GO:0016787 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;GPI anchored protein biosynthesis#GO:0180046;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;transferase complex#GO:1990234;endopeptidase complex#GO:1905369;organelle membrane#GO:0031090;endoplasmic reticulum protein-containing complex#GO:0140534;membrane#GO:0016020;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasm#GO:0005737;caspase complex#GO:0008303;peptidase complex#GO:1905368;endoplasmic reticulum subcompartment#GO:0098827;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;membrane protein complex#GO:0098796;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=25382|UniProtKB=Q9H061 Q9H061 TMEM126A PTHR16296:SF4 UNCHARACTERIZED HYPOTHALAMUS PROTEIN HT007 TRANSMEMBRANE PROTEIN 126A cellular component organization or biogenesis#GO:0071840;NADH dehydrogenase complex assembly#GO:0010257;protein-containing complex organization#GO:0043933;cellular component assembly#GO:0022607;mitochondrion organization#GO:0007005;mitochondrial respiratory chain complex assembly#GO:0033108;mitochondrial respiratory chain complex I assembly#GO:0032981;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HUMAN|HGNC=30306|UniProtKB=Q99623 Q99623 PHB2 PTHR23222:SF1 PROHIBITIN PROHIBITIN-2 cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;mitochondrion organization#GO:0007005;cellular component organization or biogenesis#GO:0071840 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739 HUMAN|HGNC=648|UniProtKB=Q7LC44 Q7LC44 ARC PTHR15962:SF0 ACTIVITY-REGULATED CYTOSKELETON-ASSOCIATED PROTEIN ACTIVITY-REGULATED CYTOSKELETON-ASSOCIATED PROTEIN regulation of neuronal synaptic plasticity#GO:0048168;regulation of biological quality#GO:0065008;regulation of synaptic plasticity#GO:0048167;regulation of signaling#GO:0023051;regulation of trans-synaptic signaling#GO:0099177;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;regulation of biological process#GO:0050789 membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;cytoplasm#GO:0005737;membraneless organelle#GO:0043228;neuron projection cytoplasm#GO:0120111;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=17732|UniProtKB=Q9UMS6 Q9UMS6 SYNPO2 PTHR24217:SF9 PUTATIVE-RELATED SYNAPTOPODIN-2 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;protein binding#GO:0005515 positive regulation of actin filament bundle assembly#GO:0032233;cellular developmental process#GO:0048869;regulation of response to stimulus#GO:0048583;developmental process#GO:0032502;regulation of actin filament-based process#GO:0032970;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of actin filament organization#GO:0110053;positive regulation of cellular process#GO:0048522;supramolecular fiber organization#GO:0097435;anatomical structure development#GO:0048856;actin filament-based process#GO:0030029;sarcomere organization#GO:0045214;cellular component assembly involved in morphogenesis#GO:0010927;organelle assembly#GO:0070925;regulation of cell communication#GO:0010646;muscle structure development#GO:0061061;regulation of cellular process#GO:0050794;actin cytoskeleton organization#GO:0030036;regulation of cytoskeleton organization#GO:0051493;regulation of supramolecular fiber organization#GO:1902903;muscle cell differentiation#GO:0042692;myofibril assembly#GO:0030239;muscle cell development#GO:0055001;anatomical structure formation involved in morphogenesis#GO:0048646;striated muscle cell differentiation#GO:0051146;regulation of small GTPase mediated signal transduction#GO:0051056;cellular component organization or biogenesis#GO:0071840;cellular anatomical entity morphogenesis#GO:0032989;regulation of actin cytoskeleton organization#GO:0032956;cytoskeleton organization#GO:0007010;positive regulation of cellular component biogenesis#GO:0044089;cellular component assembly#GO:0022607;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;positive regulation of organelle organization#GO:0010638;striated muscle cell development#GO:0055002;regulation of signaling#GO:0023051;positive regulation of cellular component organization#GO:0051130;animal gross anatomical part developmental process#GO:0160108;regulation of intracellular signal transduction#GO:1902531;regulation of cellular component biogenesis#GO:0044087;cell development#GO:0048468;actomyosin structure organization#GO:0031032;regulation of Rho protein signal transduction#GO:0035023;regulation of cellular component organization#GO:0051128;cell differentiation#GO:0030154;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;regulation of actin filament bundle assembly#GO:0032231 Z disc#GO:0030018;actomyosin#GO:0042641;contractile muscle fiber#GO:0043292;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;stress fiber#GO:0001725;cytoskeleton#GO:0005856;I band#GO:0031674;membraneless organelle#GO:0043228;cell junction#GO:0030054;sarcomere#GO:0030017;actin cytoskeleton#GO:0015629;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cell-substrate junction#GO:0030055;focal adhesion#GO:0005925;intracellular organelle#GO:0043229;myofibril#GO:0030016;actin filament bundle#GO:0032432;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;supramolecular fiber#GO:0099512 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=2935|UniProtKB=Q9Y5R5 Q9Y5R5 DMRT2 PTHR12322:SF122 DOUBLESEX AND MAB-3 RELATED TRANSCRIPTION FACTOR DMRT DOUBLESEX- AND MAB-3-RELATED TRANSCRIPTION FACTOR 2 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;sex differentiation#GO:0007548;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;developmental process involved in reproduction#GO:0003006;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;reproductive process#GO:0022414;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218 HUMAN|HGNC=25550|UniProtKB=Q96TC7 Q96TC7 RMDN3 PTHR16056:SF18 REGULATOR OF MICROTUBULE DYNAMICS PROTEIN REGULATOR OF MICROTUBULE DYNAMICS PROTEIN 3 protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;microtubule binding#GO:0008017;binding#GO:0005488 microtubule#GO:0005874;spindle microtubule#GO:0005876;supramolecular fiber#GO:0099512;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitotic spindle#GO:0072686;intracellular membrane-bounded organelle#GO:0043231;spindle pole#GO:0000922;mitochondrion#GO:0005739;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;spindle#GO:0005819;cytoskeleton#GO:0005856;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630;mitotic spindle pole#GO:0097431 microtubule or microtubule-binding cytoskeletal protein#PC00157;non-motor microtubule binding protein#PC00166;cytoskeletal protein#PC00085 HUMAN|HGNC=9583|UniProtKB=P26599 P26599 PTBP1 PTHR15592:SF19 MATRIN 3/NUCLEAR PROTEIN 220-RELATED POLYPYRIMIDINE TRACT-BINDING PROTEIN 1 binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723 regulation of cell differentiation#GO:0045595;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of developmental process#GO:0050793;regulation of RNA splicing#GO:0043484;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 RNA processing factor#PC00147 HUMAN|HGNC=16484|UniProtKB=Q9HAS3 Q9HAS3 SLC28A3 PTHR10590:SF26 SODIUM/NUCLEOSIDE COTRANSPORTER SOLUTE CARRIER FAMILY 28 MEMBER 3 monoatomic ion transmembrane transporter activity#GO:0015075;nucleoside transmembrane transporter activity#GO:0005337;solute:monoatomic cation symporter activity#GO:0015294;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;nucleobase transmembrane transporter activity#GO:0015205;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;secondary active transmembrane transporter activity#GO:0015291;nucleobase-containing compound transmembrane transporter activity#GO:0015932;solute:sodium symporter activity#GO:0015370;monoatomic cation transmembrane transporter activity#GO:0008324;carbohydrate derivative transmembrane transporter activity#GO:1901505;symporter activity#GO:0015293 nitrogen compound transport#GO:0071705;cellular process#GO:0009987;carbohydrate derivative transport#GO:1901264;nucleobase-containing compound transport#GO:0015931;transport#GO:0006810;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227 HUMAN|HGNC=10830|UniProtKB=Q99961 Q99961 SH3GL1 PTHR14167:SF63 SH3 DOMAIN-CONTAINING ENDOPHILIN-A2 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 cell junction#GO:0030054;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;presynapse#GO:0098793;synapse#GO:0045202;cellular anatomical structure#GO:0110165;glutamatergic synapse#GO:0098978;cytoplasm#GO:0005737 scaffold/adaptor protein#PC00226 HUMAN|HGNC=12246|UniProtKB=A0A0B4J1U6 A0A0B4J1U6 TRBV9 PTHR23268:SF101 T-CELL RECEPTOR BETA CHAIN T CELL RECEPTOR BETA VARIABLE 9 cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=27371|UniProtKB=Q5SVS4 Q5SVS4 SLC25A30 PTHR45618:SF11 MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED KIDNEY MITOCHONDRIAL CARRIER PROTEIN 1 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;mitochondrial inner membrane#GO:0005743;organelle envelope#GO:0031967;membrane#GO:0016020 transporter#PC00227;secondary carrier transporter#PC00258 HUMAN|HGNC=28625|UniProtKB=Q330K2 Q330K2 NDUFAF6 PTHR21181:SF13 ER membrane protein complex subunit 5-related NADH DEHYDROGENASE (UBIQUINONE) COMPLEX I, ASSEMBLY FACTOR 6 HUMAN|HGNC=24323|UniProtKB=Q16568 Q16568 CARTPT PTHR16655:SF0 COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT PROTEIN COCAINE- AND AMPHETAMINE-REGULATED TRANSCRIPT PROTEIN cell communication#GO:0007154;regulation of tissue remodeling#GO:0034103;regulation of biological quality#GO:0065008;G protein-coupled receptor signaling pathway#GO:0007186;regulation of bone resorption#GO:0045124;cellular response to stress#GO:0033554;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;negative regulation of biological process#GO:0048519;negative regulation of multicellular organismal process#GO:0051241;response to starvation#GO:0042594;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cellular response to starvation#GO:0009267;regulation of response to stimulus#GO:0048583;cellular response to nutrient levels#GO:0031669;negative regulation of response to stimulus#GO:0048585;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;response to stress#GO:0006950;regulation of bone remodeling#GO:0046850;response to nutrient levels#GO:0031667;cellular process#GO:0009987;signal transduction#GO:0007165 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;somatodendritic compartment#GO:0036477;neuronal cell body#GO:0043025;extracellular region#GO:0005576;cell body#GO:0044297 HUMAN|HGNC=22965|UniProtKB=Q7Z412 Q7Z412 PEX26 PTHR16262:SF2 PEROXISOME ASSEMBLY PROTEIN 26 PEROXISOME ASSEMBLY PROTEIN 26 protein binding#GO:0005515;binding#GO:0005488;enzyme binding#GO:0019899 intracellular protein transport#GO:0006886;transport#GO:0006810;protein transmembrane transport#GO:0071806;protein transmembrane import into intracellular organelle#GO:0044743;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;intracellular protein transmembrane transport#GO:0065002;establishment of protein localization to organelle#GO:0072594;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;organelle organization#GO:0006996;macromolecule localization#GO:0033036;peroxisome organization#GO:0007031;protein transport#GO:0015031;peroxisomal transport#GO:0043574;transmembrane transport#GO:0055085;cellular localization#GO:0051641;localization#GO:0051179;cellular component organization#GO:0016043;protein import into peroxisome matrix#GO:0016558;protein localization to organelle#GO:0033365 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;microbody#GO:0042579;peroxisome#GO:0005777;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 chaperone#PC00072 HUMAN|HGNC=16645|UniProtKB=Q13595 Q13595 TRA2A PTHR48034:SF14 TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED TRANSFORMER-2 PROTEIN HOMOLOG ALPHA nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;RNA binding#GO:0003723 RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;mRNA splicing, via spliceosome#GO:0000398;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;spliceosomal complex#GO:0005681 RNA metabolism protein#PC00031 HUMAN|HGNC=9477|UniProtKB=P56730 P56730 PRSS12 PTHR48071:SF5 SRCR DOMAIN-CONTAINING PROTEIN NEUROTRYPSIN catalytic activity#GO:0003824;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;serine-type peptidase activity#GO:0008236;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787 zymogen activation#GO:0031638;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein processing#GO:0016485;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467;metabolic process#GO:0008152;proteolysis#GO:0006508;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 axon terminus#GO:0043679;cell junction#GO:0030054;presynapse#GO:0098793;neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;glutamatergic synapse#GO:0098978;dendritic tree#GO:0097447;axon#GO:0030424;extracellular region#GO:0005576;dendrite#GO:0030425;neuron projection terminus#GO:0044306;cell projection#GO:0042995;terminal bouton#GO:0043195;distal axon#GO:0150034;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165;synapse#GO:0045202 HUMAN|HGNC=17858|UniProtKB=Q86YR5 Q86YR5 GPSM1 PTHR45954:SF2 LD33695P G PROTEIN-SIGNALING MODULATOR 1 binding#GO:0005488;molecular function regulator activity#GO:0098772;protein binding#GO:0005515;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234 cytoskeleton organization#GO:0007010;cellular process#GO:0009987;establishment of spindle localization#GO:0051293;establishment of localization in cell#GO:0051649;establishment of mitotic spindle localization#GO:0040001;organelle organization#GO:0006996;establishment of spindle orientation#GO:0051294;microtubule-based process#GO:0007017;mitotic cell cycle process#GO:1903047;establishment of localization#GO:0051234;establishment of mitotic spindle orientation#GO:0000132;cellular component organization or biogenesis#GO:0071840;establishment of organelle localization#GO:0051656;mitotic cell cycle#GO:0000278;cell cycle process#GO:0022402;establishment of cell polarity#GO:0030010;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cellular component organization#GO:0016043;cell cycle#GO:0007049;cellular localization#GO:0051641;spindle localization#GO:0051653;microtubule cytoskeleton organization#GO:0000226;localization#GO:0051179;organelle localization#GO:0051640;establishment or maintenance of cell polarity#GO:0007163 cell cortex#GO:0005938;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>AGS3#P00715;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>AGS3#P00739 HUMAN|HGNC=4559|UniProtKB=Q96SL4 Q96SL4 GPX7 PTHR11592:SF5 GLUTATHIONE PEROXIDASE PROTEIN PEROXIDASE GPX7 antioxidant activity#GO:0016209;peroxidase activity#GO:0004601;catalytic activity#GO:0003824;oxidoreductase activity, acting on peroxide as acceptor#GO:0016684;oxidoreductase activity#GO:0016491 response to stress#GO:0006950;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cellular response to oxidative stress#GO:0034599;response to stimulus#GO:0050896;response to chemical#GO:0042221;cellular response to chemical stimulus#GO:0070887;cellular response to stress#GO:0033554;cellular response to chemical stress#GO:0062197;response to oxidative stress#GO:0006979 peroxidase#PC00180;oxidoreductase#PC00176 HUMAN|HGNC=25570|UniProtKB=Q9NVH1 Q9NVH1 DNAJC11 PTHR44157:SF1 DNAJ HOMOLOG SUBFAMILY C MEMBER 11 DNAJ HOMOLOG SUBFAMILY C MEMBER 11 cellular component organization or biogenesis#GO:0071840;mitochondrial membrane organization#GO:0007006;cellular process#GO:0009987;inner mitochondrial membrane organization#GO:0007007;organelle organization#GO:0006996;cellular component organization#GO:0016043;membrane organization#GO:0061024;mitochondrion organization#GO:0007005 chaperone#PC00072 HUMAN|HGNC=24259|UniProtKB=Q9Y3C4 Q9Y3C4 TPRKB PTHR15840:SF10 CGI-121 FAMILY MEMBER EKC_KEOPS COMPLEX SUBUNIT TPRKB primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;tRNA modification#GO:0006400;RNA biosynthetic process#GO:0032774;RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;gene expression#GO:0010467;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170 cytosol#GO:0005829;nucleus#GO:0005634;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=10667|UniProtKB=Q96C92 Q96C92 ENTR1 PTHR31259:SF6 ENDOSOME-ASSOCIATED TRAFFICKING REGULATOR 1 ENDOSOME-ASSOCIATED-TRAFFICKING REGULATOR 1 regulation of cellular component biogenesis#GO:0044087;regulation of cell cycle#GO:0051726;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of plasma membrane bounded cell projection assembly#GO:0120032;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of cell projection assembly#GO:0060491;regulation of protein localization#GO:0032880;positive regulation of organelle organization#GO:0010638;positive regulation of cell projection organization#GO:0031346;positive regulation of cellular component organization#GO:0051130;regulation of cell division#GO:0051302;regulation of cytokinesis#GO:0032465;biological regulation#GO:0065007;regulation of cell cycle process#GO:0010564;positive regulation of cellular component biogenesis#GO:0044089;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of organelle assembly#GO:1902115;regulation of localization#GO:0032879;regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of cilium assembly#GO:1902017;regulation of cell projection organization#GO:0031344 cilium#GO:0005929;intracellular organelle#GO:0043229;endosome#GO:0005768;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular vesicle#GO:0097708;midbody#GO:0030496;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;microtubule organizing center#GO:0005815;centrosome#GO:0005813;recycling endosome#GO:0055037;cytoskeleton#GO:0005856;ciliary basal body#GO:0036064;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;endomembrane system#GO:0012505;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737 HUMAN|HGNC=9224|UniProtKB=Q14863 Q14863 POU6F1 PTHR11636:SF6 POU DOMAIN POU DOMAIN, CLASS 6, TRANSCRIPTION FACTOR 1 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676 regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=12609|UniProtKB=P51784 P51784 USP11 PTHR21646:SF29 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 11 hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;cysteine-type deubiquitinase activity#GO:0004843;cysteine-type peptidase activity#GO:0008234 regulation of protein stability#GO:0031647;biological regulation#GO:0065007;regulation of biological quality#GO:0065008 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 cysteine protease#PC00081 HUMAN|HGNC=6873|UniProtKB=Q15759 Q15759 MAPK11 PTHR24055:SF109 MITOGEN-ACTIVATED PROTEIN KINASE MITOGEN-ACTIVATED PROTEIN KINASE 11 protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 non-receptor serine/threonine protein kinase#PC00167 p53 pathway feedback loops 2#P04398>p38 MAPK#P04648;Ras Pathway#P04393>p38#P04558;Oxidative stress response#P00046>p38#P01135;p38 MAPK pathway#P05918>p38beta#P06029;FGF signaling pathway#P00021>p38#P00644;B cell activation#P00010>p38#P00384;TGF-beta signaling pathway#P00052>P38#P01275;Alzheimer disease-amyloid secretase pathway#P00003>MAPK#P00099;EGF receptor signaling pathway#P00018>p38#P00562;Gonadotropin-releasing hormone receptor pathway#P06664>p38#P06831;Interferon-gamma signaling pathway#P00035>Serine kinase#P00955 HUMAN|HGNC=24101|UniProtKB=Q9BXP5 Q9BXP5 SRRT PTHR13165:SF0 ARSENITE-RESISTANCE PROTEIN 2 SERRATE RNA EFFECTOR MOLECULE HOMOLOG RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;RNA biosynthetic process#GO:0032774;negative regulation of cellular process#GO:0048523;regulatory ncRNA-mediated gene silencing#GO:0031047;macromolecule metabolic process#GO:0043170;regulatory ncRNA processing#GO:0070918;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;macromolecule biosynthetic process#GO:0009059;biosynthetic process#GO:0009058;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;nucleic acid biosynthetic process#GO:0141187;miRNA processing#GO:0035196;RNA metabolic process#GO:0016070;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;negative regulation of metabolic process#GO:0009892;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;primary miRNA processing#GO:0031053;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;gene expression#GO:0010467;RNA processing#GO:0006396 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear body#GO:0016604;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232 HUMAN|HGNC=28993|UniProtKB=Q92508 Q92508 PIEZO1 PTHR13167:SF40 PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL COMPONENT PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL COMPONENT 1 channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;gated channel activity#GO:0022836;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic cation channel activity#GO:0005261;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 regulation of membrane potential#GO:0042391;cellular response to abiotic stimulus#GO:0071214;response to external stimulus#GO:0009605;regulation of biological quality#GO:0065008;detection of mechanical stimulus#GO:0050982;response to stimulus#GO:0050896;cellular response to environmental stimulus#GO:0104004;biological regulation#GO:0065007;detection of stimulus#GO:0051606;response to abiotic stimulus#GO:0009628;response to mechanical stimulus#GO:0009612;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=25853|UniProtKB=Q86WT1 Q86WT1 IFT70A PTHR20931:SF3 TETRATRICOPEPTIDE REPEAT PROTEIN 30 INTRAFLAGELLAR TRANSPORT PROTEIN 70A protein-containing complex binding#GO:0044877;binding#GO:0005488 microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;transport along microtubule#GO:0010970;establishment of localization#GO:0051234;transport#GO:0006810;intracellular transport#GO:0046907;plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton-dependent intracellular transport#GO:0030705;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle organization#GO:0006996;cilium organization#GO:0044782;localization#GO:0051179;cellular localization#GO:0051641;microtubule-based transport#GO:0099111;intraciliary transport#GO:0042073;cell projection organization#GO:0030030;microtubule-based movement#GO:0007018;cellular component organization#GO:0016043 cytoskeleton#GO:0005856;intraciliary transport particle B#GO:0030992;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;ciliary plasm#GO:0097014;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;intraciliary transport particle#GO:0030990;intracellular organelle#GO:0043229;cilium#GO:0005929;microtubule#GO:0005874;axoneme#GO:0005930;supramolecular fiber#GO:0099512;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic microtubule#GO:0005881;organelle#GO:0043226;cellular anatomical structure#GO:0110165;axonemal microtubule#GO:0005879;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025 HUMAN|HGNC=30599|UniProtKB=Q96CF2 Q96CF2 CHMP4C PTHR22761:SF77 CHARGED MULTIVESICULAR BODY PROTEIN CHARGED MULTIVESICULAR BODY PROTEIN 4C localization#GO:0051179;cellular localization#GO:0051641;membrane assembly#GO:0071709;cellular component organization#GO:0016043;late endosome to vacuole transport#GO:0045324;vacuolar transport#GO:0007034;transport#GO:0006810;intracellular transport#GO:0046907;endosomal transport#GO:0016197;nuclear envelope organization#GO:0006998;vesicle budding from membrane#GO:0006900;vesicle organization#GO:0016050;cellular component organization or biogenesis#GO:0071840;nucleus organization#GO:0006997;establishment of localization#GO:0051234;establishment of localization in cell#GO:0051649;late endosome to vacuole transport via multivesicular body sorting pathway#GO:0032511;cellular process#GO:0009987;multivesicular body sorting pathway#GO:0071985;nuclear membrane organization#GO:0071763;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;endosome transport via multivesicular body sorting pathway#GO:0032509;cellular component assembly#GO:0022607;vesicle-mediated transport#GO:0016192 cytoplasmic side of membrane#GO:0098562;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;cell periphery#GO:0071944;nucleus#GO:0005634;membrane#GO:0016020;vesicle membrane#GO:0012506;cytoplasm#GO:0005737;plasma membrane#GO:0005886;nuclear envelope#GO:0005635;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;late endosome#GO:0005770;endosome#GO:0005768;endosome membrane#GO:0010008;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;side of membrane#GO:0098552;vesicle#GO:0031982;cytoplasmic side of plasma membrane#GO:0009898;organelle envelope#GO:0031967;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 membrane traffic protein#PC00150 HUMAN|HGNC=1799|UniProtKB=Q01850 Q01850 CDR2 PTHR19232:SF1 CENTROCORTIN FAMILY MEMBER CEREBELLAR DEGENERATION-RELATED PROTEIN 2 HUMAN|HGNC=44395|UniProtKB=A1L162 A1L162 ERICH2 PTHR21520:SF2 GLUTAMATE-RICH PROTEIN 2 GLUTAMATE-RICH PROTEIN 2 HUMAN|HGNC=7995|UniProtKB=O43847 O43847 NRDC PTHR43690:SF40 NARDILYSIN NARDILYSIN hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 metabolic process#GO:0008152;proteolysis#GO:0006508;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 protease#PC00190;protein modifying enzyme#PC00260;metalloprotease#PC00153 HUMAN|HGNC=32349|UniProtKB=Q6P7N7 Q6P7N7 TMEM81 PTHR35670:SF1 TRANSMEMBRANE PROTEIN 81 TRANSMEMBRANE PROTEIN 81 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 cell recognition#GO:0008037;sexual reproduction#GO:0019953;sperm-egg recognition#GO:0035036;cell-cell recognition#GO:0009988;cellular process#GO:0009987;single fertilization#GO:0007338;fertilization#GO:0009566;reproductive process#GO:0022414 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HUMAN|HGNC=4455|UniProtKB=P21695 P21695 GPD1 PTHR11728:SF32 GLYCEROL-3-PHOSPHATE DEHYDROGENASE GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)], CYTOPLASMIC catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614 organophosphate metabolic process#GO:0019637;metabolic process#GO:0008152;phosphorus metabolic process#GO:0006793;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 oxidoreductase#PC00176;dehydrogenase#PC00092 HUMAN|HGNC=4433|UniProtKB=P00505 P00505 GOT2 PTHR11879:SF39 ASPARTATE AMINOTRANSFERASE ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL transferase activity#GO:0016740;catalytic activity#GO:0003824;transaminase activity#GO:0008483 small molecule catabolic process#GO:0044282;amino acid metabolic process#GO:0006520;proteinogenic amino acid metabolic process#GO:0170039;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739 transferase#PC00220;transaminase#PC00216;metabolite interconversion enzyme#PC00262 Asparagine and aspartate biosynthesis#P02730>Aspartate aminotransferase#P02854 HUMAN|HGNC=1108|UniProtKB=P47974 P47974 ZFP36L2 PTHR12547:SF174 CCCH ZINC FINGER/TIS11-RELATED MRNA DECAY ACTIVATOR PROTEIN ZFP36L2 mRNA binding#GO:0003729;protein-macromolecule adaptor activity#GO:0030674;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723;protein-RNA adaptor activity#GO:0140517;molecular adaptor activity#GO:0060090;mRNA 3'-UTR binding#GO:0003730;translation regulator activity#GO:0045182 regulation of RNA stability#GO:0043487;regulation of RNA metabolic process#GO:0051252;positive regulation of mRNA catabolic process#GO:0061014;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;positive regulation of RNA metabolic process#GO:0051254;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;nuclear-transcribed mRNA poly(A) tail shortening#GO:0000289;regulation of cellular process#GO:0050794;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;macromolecule metabolic process#GO:0043170;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;positive regulation of catabolic process#GO:0009896;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;nucleic acid catabolic process#GO:0141188;nucleobase-containing compound catabolic process#GO:0034655;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;RNA catabolic process#GO:0006401;regulation of biological quality#GO:0065008;positive regulation of metabolic process#GO:0009893;RNA metabolic process#GO:0016070;regulation of biological process#GO:0050789;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;regulation of mRNA stability#GO:0043488;metabolic process#GO:0008152;positive regulation of mRNA metabolic process#GO:1903313;macromolecule catabolic process#GO:0009057;mRNA destabilization#GO:0061157;regulation of mRNA metabolic process#GO:1903311;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;RNA destabilization#GO:0050779;positive regulation of macromolecule metabolic process#GO:0010604 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 RNA metabolism protein#PC00031 HUMAN|HGNC=10500|UniProtKB=P04271 P04271 S100B PTHR11639:SF153 S100 CALCIUM-BINDING PROTEIN PROTEIN S100-B calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;signaling receptor binding#GO:0005102;cation binding#GO:0043169;protein binding#GO:0005515;metal ion binding#GO:0046872 positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;positive regulation of canonical NF-kappaB signal transduction#GO:0043123;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of canonical NF-kappaB signal transduction#GO:0043122;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;regulation of cell population proliferation#GO:0042127;positive regulation of signaling#GO:0023056;positive regulation of signal transduction#GO:0009967;positive regulation of cell population proliferation#GO:0008284;regulation of biological process#GO:0050789;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;extracellular region#GO:0005576;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 calcium-binding protein#PC00060;calmodulin-related#PC00061 HUMAN|HGNC=2319|UniProtKB=O95741 O95741 CPNE6 PTHR10857:SF5 COPINE COPINE-6 lipid binding#GO:0008289;phospholipid binding#GO:0005543;binding#GO:0005488 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to metal ion#GO:0010038;cellular response to chemical stimulus#GO:0070887;response to chemical#GO:0042221;response to stimulus#GO:0050896;response to calcium ion#GO:0051592 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 calcium-binding protein#PC00060 HUMAN|HGNC=28804|UniProtKB=Q8WTR4 Q8WTR4 GDPD5 PTHR23344:SF6 GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE 2 phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;phosphoric diester hydrolase activity#GO:0008081;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788 positive regulation of developmental process#GO:0051094;positive regulation of cell differentiation#GO:0045597;regulation of cell differentiation#GO:0045595;regulation of biological process#GO:0050789;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of neuron differentiation#GO:0045664;regulation of cellular process#GO:0050794;regulation of developmental process#GO:0050793;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 phosphodiesterase#PC00185;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=29026|UniProtKB=O43147 O43147 SGSM2 PTHR22957:SF194 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN SMALL G PROTEIN SIGNALING MODULATOR 2 enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589 GTPase-activating protein#PC00257;protein-binding activity modulator#PC00095;G-protein modulator#PC00022 HUMAN|HGNC=11309|UniProtKB=P78539 P78539 SRPX PTHR46343:SF1 HYR DOMAIN-CONTAINING PROTEIN SUSHI REPEAT-CONTAINING PROTEIN SRPX endocytosis#GO:0006897;cellular component organization#GO:0016043;vacuole organization#GO:0007033;localization#GO:0051179;organelle assembly#GO:0070925;cellular component assembly#GO:0022607;lysosome organization#GO:0007040;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;vesicle organization#GO:0016050;establishment of localization#GO:0051234;import into cell#GO:0098657;cellular component organization or biogenesis#GO:0071840;transport#GO:0006810;lytic vacuole organization#GO:0080171;phagocytosis#GO:0006909;phagolysosome assembly#GO:0001845 HUMAN|HGNC=15350|UniProtKB=Q8NGC8 Q8NGC8 OR11H7 PTHR24242:SF252 G-PROTEIN COUPLED RECEPTOR OLFACTORY RECEPTOR 11H7 G-protein coupled receptor#PC00021 HUMAN|HGNC=3074|UniProtKB=Q13202 Q13202 DUSP8 PTHR10159:SF108 DUAL SPECIFICITY PROTEIN PHOSPHATASE DUAL SPECIFICITY PROTEIN PHOSPHATASE 8 phosphoprotein phosphatase activity#GO:0004721;protein tyrosine phosphatase activity#GO:0004725;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;protein tyrosine/serine/threonine phosphatase activity#GO:0008138 regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;negative regulation of response to stimulus#GO:0048585;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of MAPK cascade#GO:0043408;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;signaling#GO:0023052;regulation of cell communication#GO:0010646;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of MAPK cascade#GO:0043409;cellular response to stimulus#GO:0051716;negative regulation of biological process#GO:0048519;negative regulation of cell communication#GO:0010648;cell communication#GO:0007154;negative regulation of intracellular signal transduction#GO:1902532;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protein phosphatase#PC00195 Oxidative stress response#P00046>MKP5#P01131 HUMAN|HGNC=26164|UniProtKB=Q6N069 Q6N069 NAA16 PTHR22767:SF5 N-TERMINAL ACETYLTRANSFERASE-RELATED N-ALPHA-ACETYLTRANSFERASE 16, NATA AUXILIARY SUBUNIT molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;enzyme activator activity#GO:0008047 transferase complex#GO:1990234;catalytic complex#GO:1902494;protein acetyltransferase complex#GO:0031248;acetyltransferase complex#GO:1902493;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737 acetyltransferase#PC00038 HUMAN|HGNC=31930|UniProtKB=Q6ZS27 Q6ZS27 ZNF662 PTHR24390:SF39 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 662 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 DNA-binding transcription factor#PC00218;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=3562|UniProtKB=O15540 O15540 FABP7 PTHR11955:SF57 FATTY ACID BINDING PROTEIN FATTY ACID-BINDING PROTEIN, BRAIN fatty acid binding#GO:0005504;lipid binding#GO:0008289;carboxylic acid binding#GO:0031406;anion binding#GO:0043168;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;organic acid binding#GO:0043177 lipid transport#GO:0006869;macromolecule localization#GO:0033036;monocarboxylic acid transport#GO:0015718;localization#GO:0051179;fatty acid transport#GO:0015908;establishment of localization#GO:0051234;transport#GO:0006810;organic acid transport#GO:0015849;carboxylic acid transport#GO:0046942;lipid localization#GO:0010876 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 transfer/carrier protein#PC00219 HUMAN|HGNC=20059|UniProtKB=Q8TEY7 Q8TEY7 USP33 PTHR21646:SF32 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 33 deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;cysteine-type deubiquitinase activity#GO:0004843;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096 regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;system development#GO:0048731;regulation of biological quality#GO:0065008;anatomical structure development#GO:0048856;regulation of signaling#GO:0023051;animal gross anatomical part developmental process#GO:0160108;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;regulation of protein stability#GO:0031647;multicellular organism development#GO:0007275;developmental process#GO:0032502;regulation of response to stimulus#GO:0048583;regulation of G protein-coupled receptor signaling pathway#GO:0008277 cysteine protease#PC00081 HUMAN|HGNC=30972|UniProtKB=Q96T21 Q96T21 SECISBP2 PTHR13284:SF9 GH01354P SELENOCYSTEINE INSERTION SEQUENCE-BINDING PROTEIN 2 protein-containing complex binding#GO:0044877;mRNA 3'-UTR binding#GO:0003730;ribonucleoprotein complex binding#GO:0043021;RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729 protein biosynthetic process#GO:0160307;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;translation#GO:0006412;biosynthetic process#GO:0009058;biological regulation#GO:0065007;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;regulation of macromolecule biosynthetic process#GO:0010556;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;post-transcriptional regulation of gene expression#GO:0010608;translational elongation#GO:0006414;metabolic process#GO:0008152 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904 HUMAN|HGNC=40910|UniProtKB=H0UI37 H0UI37 TSTD3 PTHR44086:SF15 THIOSULFATE SULFURTRANSFERASE RDL2, MITOCHONDRIAL-RELATED THIOSULFATE SULFURTRANSFERASE_RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 3 transferase activity, transferring sulphur-containing groups#GO:0016782;thiosulfate-cyanide sulfurtransferase activity#GO:0004792;sulfurtransferase activity#GO:0016783;transferase activity#GO:0016740;catalytic activity#GO:0003824 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739 transferase#PC00220 HUMAN|HGNC=2645|UniProtKB=P78329 P78329 CYP4F2 PTHR24291:SF124 CYTOCHROME P450 FAMILY 4 CYTOCHROME P450 4F2 arachidonate metabolic process#GO:0019369;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;vitamin K metabolic process#GO:0042373;ketone metabolic process#GO:0042180;primary metabolic process#GO:0044238;small molecule catabolic process#GO:0044282;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;oxoacid metabolic process#GO:0043436;olefinic compound metabolic process#GO:0120254;cellular process#GO:0009987;long-chain fatty acid metabolic process#GO:0001676;icosanoid metabolic process#GO:0006690;unsaturated fatty acid metabolic process#GO:0033559;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631 oxygenase#PC00177;metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HUMAN|HGNC=17515|UniProtKB=Q8WWW8 Q8WWW8 GAB3 PTHR45960:SF3 GRB2-ASSOCIATED-BINDING PROTEIN GRB2-ASSOCIATED-BINDING PROTEIN 3 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;signaling adaptor activity#GO:0035591 biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 EGF receptor signaling pathway#P00018>Gab#P00563 HUMAN|HGNC=17260|UniProtKB=O95379 O95379 TNFAIP8 PTHR12757:SF3 TUMOR NECROSIS FACTOR INDUCED PROTEIN TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 8 biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 Huntington disease#P00029>FIP-2#P00772 HUMAN|HGNC=16262|UniProtKB=P46937 P46937 YAP1 PTHR17616:SF9 YES-ASSOCIATED PROTEIN YAP1 FAMILY MEMBER TRANSCRIPTIONAL COACTIVATOR YAP1 transcription coactivator activity#GO:0003713;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714 positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of epithelial cell proliferation#GO:0050679;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;regulation of RNA metabolic process#GO:0051252;intracellular signal transduction#GO:0035556;regulation of cell population proliferation#GO:0042127;cell communication#GO:0007154;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;hippo signaling#GO:0035329;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;positive regulation of transcription by RNA polymerase II#GO:0045944;signaling#GO:0023052;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;positive regulation of cell population proliferation#GO:0008284;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HUMAN|HGNC=21375|UniProtKB=Q5JTD7 Q5JTD7 LRRC73 PTHR24111:SF3 LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34 LEUCINE-RICH REPEAT-CONTAINING PROTEIN 73 HUMAN|HGNC=13140|UniProtKB=Q9UC06 Q9UC06 ZNF70 PTHR24381:SF82 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 70 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=26035|UniProtKB=Q6P1K1 Q6P1K1 SLC48A1 PTHR31525:SF1 HEME TRANSPORTER HRG1 HEME TRANSPORTER HRG1 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;heme binding#GO:0020037;binding#GO:0005488;tetrapyrrole binding#GO:0046906 metal ion transport#GO:0030001;nitrogen compound transport#GO:0071705;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;establishment of localization#GO:0051234;iron ion transport#GO:0006826;transport#GO:0006810;transition metal ion transport#GO:0000041;iron coordination entity transport#GO:1901678 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;lysosome#GO:0005764;lytic vacuole membrane#GO:0098852;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;vacuolar membrane#GO:0005774;lytic vacuole#GO:0000323;cytoplasm#GO:0005737;vacuole#GO:0005773;plasma membrane#GO:0005886;lysosomal membrane#GO:0005765;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227 HUMAN|HGNC=29799|UniProtKB=Q86VZ5 Q86VZ5 SGMS1 PTHR21290:SF28 SPHINGOMYELIN SYNTHETASE PHOSPHATIDYLCHOLINE:CERAMIDE CHOLINEPHOSPHOTRANSFERASE 1 phosphotransferase activity, for other substituted phosphate groups#GO:0016780;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824 organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;sphingomyelin metabolic process#GO:0006684;biosynthetic process#GO:0009058;sphingolipid biosynthetic process#GO:0030148;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;ceramide biosynthetic process#GO:0046513;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phospholipid biosynthetic process#GO:0008654;phospholipid metabolic process#GO:0006644;organophosphate biosynthetic process#GO:0090407;ceramide metabolic process#GO:0006672 organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;cell periphery#GO:0071944;endomembrane system#GO:0012505;plasma membrane#GO:0005886;cytoplasm#GO:0005737;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588 HUMAN|HGNC=2684|UniProtKB=Q15038 Q15038 DAZAP2 PTHR31638:SF4 DAZ-ASSOCIATED PROTEIN 2 DAZ-ASSOCIATED PROTEIN 2 HUMAN|HGNC=27106|UniProtKB=Q6P988 Q6P988 NOTUM PTHR21562:SF7 NOTUM-RELATED PALMITOLEOYL-PROTEIN CARBOXYLESTERASE NOTUM HUMAN|HGNC=7172|UniProtKB=Q9Y5R2 Q9Y5R2 MMP24 PTHR10201:SF138 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE-24 endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 cellular process#GO:0009987;cellular component organization#GO:0016043;catabolic process#GO:0009056;metabolic process#GO:0008152;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;cell periphery#GO:0071944;membrane#GO:0016020 metalloprotease#PC00153 Alzheimer disease-presenilin pathway#P00004>Matrix metalloprotease#P00130;Alzheimer disease-presenilin pathway#P00004>Membrane metalloprotease#P00141 HUMAN|HGNC=37636|UniProtKB=Q3C1V0 Q3C1V0 MS4A18 PTHR23320:SF37 MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 18 cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227 HUMAN|HGNC=32700|UniProtKB=Q8IW40 Q8IW40 DNAAF19 PTHR28572:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 103 DYNEIN AXONEMAL ASSEMBLY FACTOR 19 plasma membrane bounded cell projection organization#GO:0120036;regionalization#GO:0003002;multicellular organismal process#GO:0032501;developmental process#GO:0032502;plasma membrane bounded cell projection assembly#GO:0120031;specification of symmetry#GO:0009799;determination of left/right symmetry#GO:0007368;pattern specification process#GO:0007389;axonemal dynein complex assembly#GO:0070286;microtubule bundle formation#GO:0001578;organelle assembly#GO:0070925;axoneme assembly#GO:0035082;anatomical structure development#GO:0048856;microtubule cytoskeleton organization#GO:0000226;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;determination of bilateral symmetry#GO:0009855;cellular component assembly#GO:0022607;left/right pattern formation#GO:0060972;protein-containing complex organization#GO:0043933;microtubule-based process#GO:0007017;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;protein-containing complex assembly#GO:0065003;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cell projection organization#GO:0030030;inner dynein arm assembly#GO:0036159;cilium organization#GO:0044782 HUMAN|HGNC=23228|UniProtKB=Q8IZJ3 Q8IZJ3 CPAMD8 PTHR11412:SF139 MACROGLOBULIN / COMPLEMENT C3 AND PZP-LIKE ALPHA-2-MACROGLOBULIN DOMAIN-CONTAINING PROTEIN 8 peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;peptidase regulator activity#GO:0061134;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;enzyme inhibitor activity#GO:0004857;endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772 system development#GO:0048731;eye development#GO:0001654;multicellular organism development#GO:0007275;anatomical structure development#GO:0048856;animal organ development#GO:0048513;developmental process#GO:0032502;sensory organ development#GO:0007423;animal gross anatomical part developmental process#GO:0160108;visual system development#GO:0150063;multicellular organismal process#GO:0032501;sensory system development#GO:0048880 extracellular region#GO:0005576;catalytic complex#GO:1902494;extracellular protein-containing complex#GO:0140392;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 protease inhibitor#PC00191 HUMAN|HGNC=30715|UniProtKB=Q7RTY9 Q7RTY9 PRSS41 PTHR24253:SF79 TRANSMEMBRANE PROTEASE SERINE SERINE PROTEASE 41 serine-type peptidase activity#GO:0008236;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;serine hydrolase activity#GO:0017171 gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;proteolysis#GO:0006508 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 protein modifying enzyme#PC00260;protease#PC00190;serine protease#PC00203 HUMAN|HGNC=26857|UniProtKB=Q7Z745 Q7Z745 MROH2B PTHR23120:SF22 MAESTRO-RELATED HEAT DOMAIN-CONTAINING MAESTRO HEAT-LIKE REPEAT-CONTAINING PROTEIN FAMILY MEMBER 2B organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular vesicle#GO:0097708;secretory vesicle#GO:0099503;vesicle#GO:0031982;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;acrosomal vesicle#GO:0001669;intracellular organelle#GO:0043229 HUMAN|HGNC=28743|UniProtKB=Q86UF1 Q86UF1 TSPAN33 PTHR19282:SF154 TETRASPANIN TETRASPANIN-33 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HUMAN|HGNC=8600|UniProtKB=Q96RD6 Q96RD6 PANX2 PTHR15759:SF7 PANNEXIN PANNEXIN-2 channel activity#GO:0015267;wide pore channel activity#GO:0022829;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;passive transmembrane transporter activity#GO:0022803 localization#GO:0051179;monoatomic cation transport#GO:0006812;cell communication#GO:0007154;establishment of localization#GO:0051234;monoatomic ion transport#GO:0006811;transport#GO:0006810;signaling#GO:0023052;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;regulation of biological process#GO:0050789;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=30605|UniProtKB=Q9HD40 Q9HD40 SEPSECS PTHR12944:SF2 SOLUBLE LIVER ANTIGEN/LIVER PANCREAS ANTIGEN O-PHOSPHOSERYL-TRNA(SEC) SELENIUM TRANSFERASE binding#GO:0005488;nucleic acid binding#GO:0003676;tRNA binding#GO:0000049;RNA binding#GO:0003723 metabolic process#GO:0008152;translational elongation#GO:0006414;post-transcriptional regulation of gene expression#GO:0010608;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;biosynthetic process#GO:0009058;gene expression#GO:0010467;translation#GO:0006412;protein metabolic process#GO:0019538;regulation of biological process#GO:0050789;primary metabolic process#GO:0044238;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;protein biosynthetic process#GO:0160307 HUMAN|HGNC=28988|UniProtKB=Q93075 Q93075 TATDN2 PTHR46363:SF1 DEOXYRIBONUCLEASE TATDN2-RELATED 3'-5' RNA NUCLEASE TATDN2 endodeoxyribonuclease#PC00093 HUMAN|HGNC=30074|UniProtKB=O14802 O14802 POLR3A PTHR19376:SF72 DNA-DIRECTED RNA POLYMERASE DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC1 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;transcription by RNA polymerase III#GO:0006383;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070 intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234;protein-containing complex#GO:0032991;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;catalytic complex#GO:1902494;RNA polymerase III complex#GO:0005666;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 DNA-directed RNA polymerase#PC00019;RNA metabolism protein#PC00031 HUMAN|HGNC=31802|UniProtKB=Q96CB9 Q96CB9 NSUN4 PTHR22808:SF32 NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING 5-CYTOSINE RRNA METHYLTRANSFERASE NSUN4 catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity#GO:0003824;transferase activity#GO:0016740;RNA methyltransferase activity#GO:0008173;catalytic activity, acting on RNA#GO:0140098;rRNA methyltransferase activity#GO:0008649;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;catalytic activity, acting on a rRNA#GO:0140102 macromolecule modification#GO:0043412;protein-RNA complex assembly#GO:0022618;mitochondrial RNA metabolic process#GO:0000959;rRNA processing#GO:0006364;organelle assembly#GO:0070925;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;mitochondrial large ribosomal subunit assembly#GO:1902775;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;mitochondrial ribosome assembly#GO:0061668;rRNA metabolic process#GO:0016072;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;ribosomal large subunit assembly#GO:0000027;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;mitochondrial RNA modification#GO:1900864;ribosome biogenesis#GO:0042254;ribosome assembly#GO:0042255;ribosomal large subunit biogenesis#GO:0042273;RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187;ribonucleoprotein complex biogenesis#GO:0022613;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;protein-containing complex assembly#GO:0065003;protein-RNA complex organization#GO:0071826;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;gene expression#GO:0010467;cellular component assembly#GO:0022607;RNA processing#GO:0006396;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987 intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 RNA methyltransferase#PC00033 HUMAN|HGNC=9601|UniProtKB=Q9P2B2 Q9P2B2 PTGFRN PTHR12207:SF3 V-SET AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN PROSTAGLANDIN F2 RECEPTOR NEGATIVE REGULATOR membrane#GO:0016020;cellular anatomical structure#GO:0110165 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=13476|UniProtKB=Q9H313 Q9H313 TTYH1 PTHR12424:SF5 TWEETY-RELATED PROTEIN TWEETY HOMOLOG 1 channel activity#GO:0015267;monoatomic anion channel activity#GO:0005253;gated channel activity#GO:0022836;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic anion transmembrane transporter activity#GO:0008509;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;chloride channel activity#GO:0005254;chloride transmembrane transporter activity#GO:0015108;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803 bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endomembrane system#GO:0012505;plasma membrane#GO:0005886;cytoplasm#GO:0005737;membrane#GO:0016020;cell periphery#GO:0071944;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 ion channel#PC00133;transporter#PC00227 HUMAN|HGNC=963|UniProtKB=Q9UIF8 Q9UIF8 BAZ2B PTHR45915:SF1 TRANSCRIPTION INTERMEDIARY FACTOR BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 2B transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 negative regulation of cellular process#GO:0048523;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;epigenetic regulation of gene expression#GO:0040029;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;chromatin organization#GO:0006325;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;heterochromatin formation#GO:0031507;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of gene expression, epigenetic#GO:0045814;cellular component organization or biogenesis#GO:0071840;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;cellular component assembly#GO:0022607;heterochromatin organization#GO:0070828;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892 intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;chromosome#GO:0005694;nucleus#GO:0005634;chromatin#GO:0000785;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=32538|UniProtKB=Q58FF6 Q58FF6 HSP90AB4P PTHR11528:SF79 HEAT SHOCK PROTEIN 90 FAMILY MEMBER HEAT SHOCK PROTEIN HSP 90-BETA-RELATED carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP binding#GO:0005524;binding#GO:0005488;ATP-dependent activity#GO:0140657;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887 protein metabolic process#GO:0019538;regulation of biological quality#GO:0065008;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;protein folding#GO:0006457;response to abiotic stimulus#GO:0009628;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;protein stabilization#GO:0050821;metabolic process#GO:0008152;gene expression#GO:0010467;protein maturation#GO:0051604;biological regulation#GO:0065007;response to temperature stimulus#GO:0009266;biosynthetic process#GO:0009058;response to heat#GO:0009408;cellular response to heat#GO:0034605;response to stress#GO:0006950;regulation of protein stability#GO:0031647;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;plasma membrane#GO:0005886;perinuclear region of cytoplasm#GO:0048471;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;cytosol#GO:0005829 Hsp90 family chaperone#PC00028;chaperone#PC00072 HUMAN|HGNC=9410|UniProtKB=Q04759 Q04759 PRKCQ PTHR24356:SF181 SERINE/THREONINE-PROTEIN KINASE PROTEIN KINASE C THETA TYPE protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 non-receptor serine/threonine protein kinase#PC00167 Alzheimer disease-amyloid secretase pathway#P00003>PKC#P00109;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>PKC#P00745;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>PKC#P01074;5HT2 type receptor mediated signaling pathway#P04374>PKC#P04420;Apoptosis signaling pathway#P00006>PKCs#P00318;FGF signaling pathway#P00021>PKC#P00648;Thyrotropin-releasing hormone receptor signaling pathway#P04394>PKC#P04583;Wnt signaling pathway#P00057>Protein Kinase C#P01458;CCKR signaling map#P06959>PKCtheta#P07140;Oxytocin receptor mediated signaling pathway#P04391>PKC#P04533;T cell activation#P00053>PKC-theta#P01318;Endothelin signaling pathway#P00019>PKC#P00568;Histamine H1 receptor mediated signaling pathway#P04385>PKC#P04487;EGF receptor signaling pathway#P00018>PKC#P00565;Gonadotropin-releasing hormone receptor pathway#P06664>PKCe/theta#P06798;VEGF signaling pathway#P00056>PKC#P01425;Angiogenesis#P00005>PKC#P00219 HUMAN|HGNC=3795|UniProtKB=P41439 P41439 FOLR3 PTHR10517:SF17 FOLATE RECEPTOR FOLATE RECEPTOR GAMMA molecular transducer activity#GO:0060089;cargo receptor activity#GO:0038024;signaling receptor activity#GO:0038023 transport#GO:0006810;organic acid transport#GO:0015849;carboxylic acid transport#GO:0046942;localization#GO:0051179;establishment of localization#GO:0051234;nitrogen compound transport#GO:0071705;dicarboxylic acid transport#GO:0006835;vitamin transport#GO:0051180 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=9777|UniProtKB=P20336 P20336 RAB3A PTHR47980:SF9 LD44762P RAS-RELATED PROTEIN RAB-3A binding#GO:0005488;myosin binding#GO:0017022;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515 regulated exocytosis#GO:0045055;plasma membrane bounded cell projection morphogenesis#GO:0120039;acrosomal vesicle exocytosis#GO:0060478;neuron differentiation#GO:0030182;vesicle-mediated transport in synapse#GO:0099003;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;exocytosis#GO:0006887;cell projection morphogenesis#GO:0048858;synaptic signaling#GO:0099536;single fertilization#GO:0007338;neuron projection development#GO:0031175;cellular process#GO:0009987;synaptic vesicle exocytosis#GO:0016079;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;neurotransmitter transport#GO:0006836;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;cellular localization#GO:0051641;neuron development#GO:0048666;axonogenesis#GO:0007409;secretion by cell#GO:0032940;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;acrosome reaction#GO:0007340;regulation of biological process#GO:0050789;cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;cell differentiation#GO:0030154;fertilization#GO:0009566;cell development#GO:0048468;export from cell#GO:0140352;signaling#GO:0023052;calcium-ion regulated exocytosis#GO:0017156;transport#GO:0006810;neuron projection morphogenesis#GO:0048812;synaptic vesicle cycle#GO:0099504;developmental process#GO:0032502;establishment of localization#GO:0051234;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;axon development#GO:0061564;multicellular organismal process#GO:0032501;neurotransmitter secretion#GO:0007269;plasma membrane bounded cell projection organization#GO:0120036;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;trans-synaptic signaling#GO:0099537;signal release#GO:0023061;sexual reproduction#GO:0019953;secretion#GO:0046903;anatomical structure development#GO:0048856;cell communication#GO:0007154;localization#GO:0051179;system development#GO:0048731;signal release from synapse#GO:0099643;chemical synaptic transmission#GO:0007268;anterograde trans-synaptic signaling#GO:0098916;reproductive process#GO:0022414 organelle membrane#GO:0031090;transport vesicle membrane#GO:0030658;endomembrane system#GO:0012505;transport vesicle#GO:0030133;plasma membrane#GO:0005886;membrane#GO:0016020;vesicle membrane#GO:0012506;cell periphery#GO:0071944;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;axon#GO:0030424;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;synaptic vesicle#GO:0008021;vesicle#GO:0031982;synaptic vesicle membrane#GO:0030672;cell junction#GO:0030054;bounding membrane of organelle#GO:0098588;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;secretory vesicle#GO:0099503;neuron projection#GO:0043005;presynapse#GO:0098793;exocytic vesicle#GO:0070382;endosome#GO:0005768;intracellular organelle#GO:0043229;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cell projection#GO:0042995;intracellular vesicle#GO:0097708 Synaptic vesicle trafficking#P05734>Rab3A#P05780 HUMAN|HGNC=33504|UniProtKB=Q6UWF3 Q6UWF3 SCIMP PTHR12044:SF11 BCL2 INTERACTING MEDIATOR OF CELL DEATH SLP ADAPTER AND CSK-INTERACTING MEMBRANE PROTEIN nuclear division#GO:0000280;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;meiosis I#GO:0007127;meiotic cell cycle process#GO:1903046;cellular component organization#GO:0016043;cell cycle process#GO:0022402;regulation of biological process#GO:0050789;meiotic cell cycle#GO:0051321;positive regulation of response to external stimulus#GO:0032103;cellular component organization or biogenesis#GO:0071840;organelle organization#GO:0006996;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;regulation of response to external stimulus#GO:0032101;meiosis I cell cycle process#GO:0061982;sexual reproduction#GO:0019953;organelle fission#GO:0048285;cell cycle#GO:0007049;positive regulation of signal transduction#GO:0009967;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of response to biotic stimulus#GO:0002831;reproductive process#GO:0022414;regulation of response to stimulus#GO:0048583;meiotic nuclear division#GO:0140013;positive regulation of response to biotic stimulus#GO:0002833;positive regulation of cellular process#GO:0048522;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HUMAN|HGNC=4234|UniProtKB=P55040 P55040 GEM PTHR45775:SF4 RAD, GEM/KIR FAMILY MEMBER 2, ISOFORM C GTP-BINDING PROTEIN GEM ion channel regulator activity#GO:0099106;molecular function regulator activity#GO:0098772;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;anion binding#GO:0043168;ion binding#GO:0043167;transporter regulator activity#GO:0141108;channel regulator activity#GO:0016247;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;carbohydrate derivative binding#GO:0097367;calcium channel regulator activity#GO:0005246;ribonucleotide binding#GO:0032553;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;binding#GO:0005488;nucleoside phosphate binding#GO:1901265;guanyl nucleotide binding#GO:0019001;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 HUMAN|HGNC=10848|UniProtKB=Q15465 Q15465 SHH PTHR11889:SF36 HEDGEHOG SONIC HEDGEHOG PROTEIN metal ion binding#GO:0046872;protein binding#GO:0005515;cation binding#GO:0043169;small molecule binding#GO:0036094;binding#GO:0005488;signaling receptor binding#GO:0005102;ion binding#GO:0043167;calcium ion binding#GO:0005509 biological regulation#GO:0065007;multicellular organismal process#GO:0032501;oligodendrocyte differentiation#GO:0048709;glial cell differentiation#GO:0010001;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;developmental process#GO:0032502;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;system development#GO:0048731;smoothened signaling pathway#GO:0007224;cell communication#GO:0007154;anatomical structure development#GO:0048856;nervous system development#GO:0007399;signal transduction#GO:0007165;cellular process#GO:0009987;gliogenesis#GO:0042063;multicellular organism development#GO:0007275;cell fate specification#GO:0001708;cell surface receptor signaling pathway#GO:0007166;signaling#GO:0023052;central nervous system development#GO:0007417;cell differentiation#GO:0030154;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;cell fate commitment#GO:0045165;animal gross anatomical part developmental process#GO:0160108 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 Hedgehog signaling pathway#P00025>Hedgehog#P00688 HUMAN|HGNC=25735|UniProtKB=Q14D04 Q14D04 VEPH1 PTHR21630:SF10 VEPH-A/MELTED VENTRICULAR ZONE-EXPRESSED PH DOMAIN-CONTAINING PROTEIN HOMOLOG 1 phosphatidylinositol phosphate binding#GO:1901981;lipid binding#GO:0008289;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;phospholipid binding#GO:0005543;anion binding#GO:0043168 regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=30450|UniProtKB=Q6XQN6 Q6XQN6 NAPRT PTHR11098:SF1 NICOTINATE PHOSPHORIBOSYLTRANSFERASE NICOTINATE PHOSPHORIBOSYLTRANSFERASE ligase activity, forming carbon-nitrogen bonds#GO:0016879;catalytic activity#GO:0003824;ligase activity#GO:0016874 nucleobase-containing small molecule metabolic process#GO:0055086;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;nicotinamide nucleotide metabolic process#GO:0046496;organophosphate metabolic process#GO:0019637;NAD+ metabolic process#GO:0019674;nucleotide biosynthetic process#GO:0009165;organophosphate biosynthetic process#GO:0090407;nucleotide metabolic process#GO:0009117;pyridine-containing compound metabolic process#GO:0072524;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 glycosyltransferase#PC00111;transferase#PC00220 HUMAN|HGNC=15341|UniProtKB=Q96R30 Q96R30 OR2V2 PTHR26453:SF235 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2V2 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;response to chemical#GO:0042221;response to stimulus#GO:0050896;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;detection of chemical stimulus#GO:0009593;system process#GO:0003008;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;nervous system process#GO:0050877;sensory perception#GO:0007600 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=16318|UniProtKB=Q6NXS1 Q6NXS1 PPP1R2B PTHR12398:SF27 PROTEIN PHOSPHATASE INHIBITOR PROTEIN PHOSPHATASE INHIBITOR 2 FAMILY MEMBER B enzyme regulator activity#GO:0030234;protein phosphatase regulator activity#GO:0019888;molecular function inhibitor activity#GO:0140678;protein phosphatase inhibitor activity#GO:0004864;enzyme inhibitor activity#GO:0004857;phosphatase regulator activity#GO:0019208;phosphatase inhibitor activity#GO:0019212;molecular function regulator activity#GO:0098772 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 phosphatase inhibitor#PC00183 HUMAN|HGNC=1470|UniProtKB=Q96RR4 Q96RR4 CAMKK2 PTHR43895:SF39 CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED CALCIUM_CALMODULIN-DEPENDENT PROTEIN KINASE KINASE 2 protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096 cell communication#GO:0007154;calcium-mediated signaling#GO:0019722;intracellular signal transduction#GO:0035556;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;signaling#GO:0023052 HUMAN|HGNC=12687|UniProtKB=P40337 P40337 VHL PTHR15160:SF16 VON HIPPEL-LINDAU PROTEIN VON HIPPEL-LINDAU DISEASE TUMOR SUPPRESSOR protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714;transcription regulator activity#GO:0140110;enzyme-substrate adaptor activity#GO:0140767;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 regulation of DNA-templated transcription#GO:0006355;protein metabolic process#GO:0019538;regulation of RNA metabolic process#GO:0051252;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;regulation of gene expression#GO:0010468;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;regulation of nucleobase-containing compound metabolic process#GO:0019219;proteasomal protein catabolic process#GO:0010498;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987 intracellular organelle#GO:0043229;transferase complex#GO:1990234;catalytic complex#GO:1902494;ubiquitin ligase complex#GO:0000151;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Hypoxia response via HIF activation#P00030>VHL#P00816 HUMAN|HGNC=9904|UniProtKB=Q9Y580 Q9Y580 RBM7 PTHR13798:SF4 RNA BINDING MOTIF RBM PROTEIN -RELATED RNA-BINDING PROTEIN 7 nucleic acid binding#GO:0003676;binding#GO:0005488;single-stranded RNA binding#GO:0003727;RNA binding#GO:0003723 regulation of gene expression#GO:0010468;regulation of mRNA metabolic process#GO:1903311;regulation of biosynthetic process#GO:0009889;regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of mRNA processing#GO:0050684;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of alternative mRNA splicing, via spliceosome#GO:0000381;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of biological process#GO:0050789 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513 RNA metabolism protein#PC00031 HUMAN|HGNC=14383|UniProtKB=Q8N9R6 Q8N9R6 CDRT4 PTHR37885:SF1 CMT1A DUPLICATED REGION TRANSCRIPT 4 PROTEIN CMT1A DUPLICATED REGION TRANSCRIPT 4 PROTEIN HUMAN|HGNC=33601|UniProtKB=A6NGB0 A6NGB0 TMEM191C PTHR38498:SF1 TRANSMEMBRANE PROTEIN 191B-RELATED TRANSMEMBRANE PROTEIN 191C HUMAN|HGNC=18521|UniProtKB=Q9NU39 Q9NU39 FOXD4L1 PTHR11829:SF404 FORKHEAD BOX PROTEIN FORKHEAD BOX PROTEIN D4-RELATED double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;developmental process#GO:0032502;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=28050|UniProtKB=Q6FI81 Q6FI81 CIAPIN1 PTHR13273:SF17 ANAMORSIN ANAMORSIN cellular process#GO:0009987;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;iron-sulfur cluster assembly#GO:0016226;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=8484|UniProtKB=Q15617 Q15617 OR8G1 PTHR48018:SF56 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 8G1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;sensory perception of smell#GO:0007608;sensory perception#GO:0007600;nervous system process#GO:0050877;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=23519|UniProtKB=Q96D05 Q96D05 FAM241B PTHR33690:SF2 DUF4605 DOMAIN-CONTAINING PROTEIN PROTEIN FAM241B organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=16660|UniProtKB=Q96RJ6 Q96RJ6 FERD3L PTHR23349:SF63 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST FER3-LIKE PROTEIN sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700 regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 basic helix-loop-helix transcription factor#PC00055;DNA-binding transcription factor#PC00218 HUMAN|HGNC=14738|UniProtKB=Q8NGK1 Q8NGK1 OR51G1 PTHR26450:SF140 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 51G1 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=15153|UniProtKB=Q8NH70 Q8NH70 OR4A16 PTHR48002:SF159 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 4A16 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=32006|UniProtKB=Q5VVP1 Q5VVP1 SPATA31A6 PTHR21859:SF55 ACROSOME-SPECIFIC PROTEIN SPERMATOGENESIS-ASSOCIATED PROTEIN 31A1-RELATED HUMAN|HGNC=3372|UniProtKB=O95936 O95936 EOMES PTHR11267:SF13 T-BOX PROTEIN-RELATED EOMESODERMIN HOMOLOG transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 immune effector process#GO:0002252;cell fate specification#GO:0001708;leukocyte activation involved in immune response#GO:0002366;anatomical structure formation involved in morphogenesis#GO:0048646;endoderm development#GO:0007492;multicellular organism development#GO:0007275;embryonic morphogenesis#GO:0048598;mesoderm development#GO:0007498;lymphocyte activation involved in immune response#GO:0002285;cellular process#GO:0009987;T cell activation involved in immune response#GO:0002286;T cell differentiation#GO:0030217;endoderm formation#GO:0001706;embryo development#GO:0009790;lymphocyte activation#GO:0046649;formation of primary germ layer#GO:0001704;immune system process#GO:0002376;animal gross anatomical part developmental process#GO:0160108;cell fate commitment#GO:0045165;cell activation involved in immune response#GO:0002263;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;mononuclear cell differentiation#GO:1903131;T cell activation#GO:0042110;gastrulation#GO:0007369;leukocyte differentiation#GO:0002521;cell development#GO:0048468;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;response to stimulus#GO:0050896;developmental process#GO:0032502;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;immune response#GO:0006955;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;hemopoiesis#GO:0030097;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;mesoderm formation#GO:0001707;multicellular organismal process#GO:0032501;tissue development#GO:0009888;lymphocyte differentiation#GO:0030098;cell activation#GO:0001775;regulation of RNA metabolic process#GO:0051252;tissue morphogenesis#GO:0048729;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;mesoderm morphogenesis#GO:0048332;leukocyte activation#GO:0045321;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229 immunoglobulin fold transcription factor#PC00251;Rel homology transcription factor#PC00252 HUMAN|HGNC=25922|UniProtKB=Q8N539 Q8N539 FIBCD1 PTHR19143:SF45 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN C DOMAIN-CONTAINING PROTEIN 1 extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HUMAN|HGNC=14435|UniProtKB=Q8N187 Q8N187 CARF PTHR14694:SF1 CALCIUM-RESPONSIVE TRANSCRIPTION FACTOR CALCIUM-RESPONSIVE TRANSCRIPTION FACTOR sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=5652|UniProtKB=A0A075B6R2 A0A075B6R2 IGHV4-4 PTHR23266:SF387 IMMUNOGLOBULIN HEAVY CHAIN IG-LIKE DOMAIN-CONTAINING PROTEIN-RELATED antigen binding#GO:0003823;binding#GO:0005488 immune response#GO:0006955;adaptive immune response#GO:0002250;response to stimulus#GO:0050896;immune effector process#GO:0002252;immune system process#GO:0002376;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=6089|UniProtKB=Q9Y581 Q9Y581 INSL6 PTHR12004:SF1 RELAXIN INSULIN-LIKE PEPTIDE INSL6 peptide hormone#PC00179;intercellular signal molecule#PC00207 HUMAN|HGNC=9141|UniProtKB=Q15126 Q15126 PMVK PTHR13101:SF1 PHOSPHOMEVALONATE KINASE PHOSPHOMEVALONATE KINASE phosphotransferase activity, phosphate group as acceptor#GO:0016776;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 isoprenoid metabolic process#GO:0006720;organophosphate biosynthetic process#GO:0090407;acetyl-CoA metabolic process#GO:0006084;phospholipid metabolic process#GO:0006644;nucleoside phosphate metabolic process#GO:0006753;phospholipid biosynthetic process#GO:0008654;primary metabolic process#GO:0044238;acyl-CoA metabolic process#GO:0006637;secondary alcohol biosynthetic process#GO:1902653;steroid biosynthetic process#GO:0006694;sterol metabolic process#GO:0016125;lipid metabolic process#GO:0006629;cholesterol metabolic process#GO:0008203;small molecule biosynthetic process#GO:0044283;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;lipid biosynthetic process#GO:0008610;organophosphate metabolic process#GO:0019637;isoprenoid biosynthetic process#GO:0008299;secondary alcohol metabolic process#GO:1902652;small molecule metabolic process#GO:0044281;purine-containing compound metabolic process#GO:0072521;phosphorus metabolic process#GO:0006793;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;alcohol metabolic process#GO:0006066;sterol biosynthetic process#GO:0016126;steroid metabolic process#GO:0008202;cholesterol biosynthetic process#GO:0006695;alcohol biosynthetic process#GO:0046165;cellular process#GO:0009987;sulfur compound metabolic process#GO:0006790 transferase#PC00220;metabolite interconversion enzyme#PC00262;kinase#PC00137 Cholesterol biosynthesis#P00014>Phosphomevalonate kinase#P00500 HUMAN|HGNC=9969|UniProtKB=P35251 P35251 RFC1 PTHR23389:SF35 CHROMOSOME TRANSMISSION FIDELITY FACTOR 18 REPLICATION FACTOR C SUBUNIT 1 catalytic activity, acting on DNA#GO:0140097;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;ATP-dependent activity, acting on DNA#GO:0008094;DNA binding#GO:0003677;binding#GO:0005488;nucleic acid binding#GO:0003676;ATP-dependent activity#GO:0140657 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA metabolism protein#PC00009 DNA replication#P00017>RFC#P00529 HUMAN|HGNC=11608|UniProtKB=P21731 P21731 TBXA2R PTHR11866:SF5 G-PROTEIN COUPLED RECEPTOR FAMILY 1 MEMBER THROMBOXANE A2 RECEPTOR transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930 inflammatory response#GO:0006954;circulatory system process#GO:0003013;G protein-coupled receptor signaling pathway#GO:0007186;positive regulation of cytosolic calcium ion concentration#GO:0007204;regulation of biological quality#GO:0065008;cell communication#GO:0007154;positive regulation of multicellular organismal process#GO:0051240;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signaling#GO:0023052;regulation of cellular process#GO:0050794;positive regulation of blood pressure#GO:0045777;response to stimulus#GO:0050896;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;regulation of anatomical structure size#GO:0090066;regulation of system process#GO:0044057;defense response#GO:0006952;system process#GO:0003008;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;response to stress#GO:0006950;regulation of blood pressure#GO:0008217;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;blood circulation#GO:0008015 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=37865|UniProtKB=A0A0U1RQE8 A0A0U1RQE8 GLYATL1B PTHR15298:SF16 L-COA N-ACYLTRANSFERASE-RELATED GLYCINE N-ACYLTRANSFERASE-LIKE PROTEIN 1B-RELATED catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 cellular process#GO:0009987;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;amino acid metabolic process#GO:0006520;proteinogenic amino acid metabolic process#GO:0170039;small molecule metabolic process#GO:0044281;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436 mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 acyltransferase#PC00042 HUMAN|HGNC=10538|UniProtKB=O43290 O43290 SART1 PTHR14152:SF5 SQUAMOUS CELL CARCINOMA ANTIGEN RECOGNISED BY CYTOTOXIC T LYMPHOCYTES U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 1 nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;RNA splicing, via transesterification reactions#GO:0000375;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;mRNA cis splicing, via spliceosome#GO:0045292;mRNA metabolic process#GO:0016071;RNA splicing#GO:0008380;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;cellular component biogenesis#GO:0044085;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;gene expression#GO:0010467 U4/U6 x U5 tri-snRNP complex#GO:0046540;protein-containing complex#GO:0032991;nucleus#GO:0005634;small nuclear ribonucleoprotein complex#GO:0030532;nuclear protein-containing complex#GO:0140513;Sm-like protein family complex#GO:0120114;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;spliceosomal complex#GO:0005681;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;spliceosomal snRNP complex#GO:0097525;intracellular organelle#GO:0043229;spliceosomal tri-snRNP complex#GO:0097526;precatalytic spliceosome#GO:0071011;ribonucleoprotein complex#GO:1990904 extracellular matrix protein#PC00102 HUMAN|HGNC=18464|UniProtKB=A4D2P6 A4D2P6 GRID2IP PTHR45725:SF3 FORMIN HOMOLOGY 2 FAMILY MEMBER DELPHILIN HUMAN|HGNC=24381|UniProtKB=Q8TF08 Q8TF08 COX7B2 PTHR16716:SF1 CYTOCHROME C OXIDASE SUBUNIT 7B, MITOCHONDRIAL CYTOCHROME C OXIDASE SUBUNIT 7B2, MITOCHONDRIAL mitochondrion#GO:0005739;cytochrome complex#GO:0070069;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;transmembrane transporter complex#GO:1902495;respiratory chain complex IV#GO:0045277;respiratory chain complex#GO:0098803;oxidoreductase complex#GO:1990204;membrane#GO:0016020;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;transporter complex#GO:1990351 metabolite interconversion enzyme#PC00262;oxidase#PC00175;oxidoreductase#PC00176 HUMAN|HGNC=11958|UniProtKB=Q96L91 Q96L91 EP400 PTHR46459:SF1 E1A-BINDING PROTEIN P400-RELATED E1A-BINDING PROTEIN P400 chromatin binding#GO:0003682;binding#GO:0005488 response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA damage response#GO:0006974;cellular response to stress#GO:0033554 nuclear protein-containing complex#GO:0140513;histone acetyltransferase complex#GO:0000123;NuA4 histone acetyltransferase complex#GO:0035267;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;chromatin#GO:0000785;acetyltransferase complex#GO:1902493;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;protein acetyltransferase complex#GO:0031248;ATPase complex#GO:1904949;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle lumen#GO:0043233;membraneless organelle#GO:0043228;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;H4 histone acetyltransferase complex#GO:1902562;nuclear chromosome#GO:0000228;histone deacetylase complex#GO:0000118;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;INO80-type complex#GO:0097346;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;Swr1 complex#GO:0000812;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;SWI/SNF superfamily-type complex#GO:0070603 Wnt signaling pathway#P00057>SWI/SNF#P01435 HUMAN|HGNC=33624|UniProtKB=Q5TBC7 Q5TBC7 BCL2L15 PTHR36466:SF1 BCL-2-LIKE PROTEIN 15 BCL-2-LIKE PROTEIN 15 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=17557|UniProtKB=Q9UIC8 Q9UIC8 LCMT1 PTHR13600:SF33 LEUCINE CARBOXYL METHYLTRANSFERASE LEUCINE CARBOXYL METHYLTRANSFERASE 1 S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;O-methyltransferase activity#GO:0008171;catalytic activity, acting on a protein#GO:0140096;protein methyltransferase activity#GO:0008276;transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;catalytic activity#GO:0003824 regulation of mitotic nuclear division#GO:0007088;regulation of mitotic sister chromatid separation#GO:0010965;regulation of response to stimulus#GO:0048583;regulation of chromosome segregation#GO:0051983;regulation of chromosome organization#GO:0033044;regulation of nuclear division#GO:0051783;regulation of cell cycle process#GO:0010564;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of chromosome separation#GO:1905818;regulation of mitotic metaphase/anaphase transition#GO:0030071;regulation of mitotic cell cycle#GO:0007346;regulation of mitotic sister chromatid segregation#GO:0033047;regulation of mitotic cell cycle phase transition#GO:1901990;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;regulation of cell communication#GO:0010646;regulation of sister chromatid segregation#GO:0033045;regulation of cell cycle#GO:0051726;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of cell cycle phase transition#GO:1901987 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 methyltransferase#PC00155 HUMAN|HGNC=19039|UniProtKB=Q7Z695 Q7Z695 ADCK2 PTHR45890:SF26 AARF DOMAIN CONTAINING KINASE 2 (PREDICTED) NADH:UBIQUINONE OXIDOREDUCTASE SUBUNIT B2 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=19866|UniProtKB=Q05BQ5 Q05BQ5 MBTD1 PTHR12247:SF79 POLYCOMB GROUP PROTEIN MBT DOMAIN-CONTAINING PROTEIN 1 protein binding#GO:0005515;chromatin binding#GO:0003682;histone binding#GO:0042393;binding#GO:0005488 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of metabolic process#GO:0009892;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=19632|UniProtKB=Q8NGE1 Q8NGE1 OR6C4 PTHR26454:SF9 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 6C4 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=13165|UniProtKB=Q03938 Q03938 ZNF90 PTHR24384:SF92 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED ZINC FINGER PROTEIN 90 RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218 HUMAN|HGNC=25116|UniProtKB=Q7M4L6 Q7M4L6 SHF PTHR15127:SF28 HEAVYWEIGHT, ISOFORM A SH2 DOMAIN-CONTAINING ADAPTER PROTEIN F protein binding#GO:0005515;binding#GO:0005488 HUMAN|HGNC=15297|UniProtKB=Q8NGG3 Q8NGG3 OR5T3 PTHR48018:SF194 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5T1-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;cellular process#GO:0009987;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;sensory perception of smell#GO:0007608;regulation of cellular process#GO:0050794;signaling#GO:0023052;G protein-coupled receptor signaling pathway#GO:0007186;sensory perception#GO:0007600;nervous system process#GO:0050877;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=18779|UniProtKB=Q9UJN7 Q9UJN7 ZNF391 PTHR24381:SF423 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 391 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=4626|UniProtKB=P08263 P08263 GSTA1 PTHR11571:SF107 GLUTATHIONE S-TRANSFERASE GLUTATHIONE S-TRANSFERASE A1 transferase activity#GO:0016740;catalytic activity#GO:0003824;glutathione transferase activity#GO:0004364;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765 response to stimulus#GO:0050896;response to chemical#GO:0042221;cellular response to xenobiotic stimulus#GO:0071466;xenobiotic metabolic process#GO:0006805;sulfur compound metabolic process#GO:0006790;modified amino acid metabolic process#GO:0006575;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;glutathione metabolic process#GO:0006749;metabolic process#GO:0008152;response to xenobiotic stimulus#GO:0009410;cellular response to chemical stimulus#GO:0070887 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 transferase#PC00220 HUMAN|HGNC=27611|UniProtKB=Q6ZN19 Q6ZN19 ZNF841 PTHR24376:SF128 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 836-RELATED regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HUMAN|HGNC=30964|UniProtKB=Q5W041 Q5W041 ARMC3 PTHR46618:SF1 ARMADILLO REPEAT-CONTAINING PROTEIN 3 ARMADILLO REPEAT-CONTAINING PROTEIN 3 HUMAN|HGNC=20581|UniProtKB=Q9NR63 Q9NR63 CYP26B1 PTHR24286:SF177 CYTOCHROME P450 26 CYTOCHROME P450 26B1 oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;monooxygenase activity#GO:0004497 lipid metabolic process#GO:0006629;developmental process#GO:0032502;metabolic process#GO:0008152;diterpenoid metabolic process#GO:0016101;multicellular organism development#GO:0007275;retinoid metabolic process#GO:0001523;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;lipid catabolic process#GO:0016042;nervous system development#GO:0007399;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;monocarboxylic acid catabolic process#GO:0072329;hormone metabolic process#GO:0042445;terpenoid metabolic process#GO:0006721;animal gross anatomical part developmental process#GO:0160108;oxoacid metabolic process#GO:0043436;regulation of biological quality#GO:0065008;system development#GO:0048731;isoprenoid metabolic process#GO:0006720;anatomical structure development#GO:0048856;regulation of hormone levels#GO:0010817;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;small molecule catabolic process#GO:0044282;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;central nervous system development#GO:0007417 oxygenase#PC00177 HUMAN|HGNC=21293|UniProtKB=Q8NDA2 Q8NDA2 HMCN2 PTHR45080:SF28 CONTACTIN 5 HEMICENTIN-2 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 synapse organization#GO:0050808;cell adhesion#GO:0007155;cellular component organization or biogenesis#GO:0071840;homophilic cell-cell adhesion#GO:0007156;cellular component organization#GO:0016043;cell-cell adhesion#GO:0098609;cellular process#GO:0009987;cell junction organization#GO:0034330 axon#GO:0030424;cell periphery#GO:0071944;cell body#GO:0044297;neuron projection#GO:0043005;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;neuronal cell body#GO:0043025;somatodendritic compartment#GO:0036477;cell projection#GO:0042995;cellular anatomical structure#GO:0110165 HUMAN|HGNC=16217|UniProtKB=Q9BZ19 Q9BZ19 ANKRD60 PTHR22677:SF3 ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 60 ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 60 HUMAN|HGNC=31745|UniProtKB=Q8WWR9 Q8WWR9 PPDPFL PTHR14572:SF1 PANCREATIC PROGENITOR CELL DIFFERENTIATION AND PROLIFERATION FACTOR PANCREATIC PROGENITOR CELL DIFFERENTIATION AND PROLIFERATION FACTOR-LIKE PROTEIN HUMAN|HGNC=10945|UniProtKB=O00341 O00341 SLC1A7 PTHR11958:SF22 SODIUM/DICARBOXYLATE SYMPORTER-RELATED EXCITATORY AMINO ACID TRANSPORTER 5 monoatomic cation transmembrane transporter activity#GO:0008324;sodium:dicarboxylate symporter activity#GO:0017153;symporter activity#GO:0015293;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;amino acid transmembrane transporter activity#GO:0015171;amino acid:sodium symporter activity#GO:0005283;solute:sodium symporter activity#GO:0015370;carboxylic acid transmembrane transporter activity#GO:0046943;acidic amino acid transmembrane transporter activity#GO:0015172;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;L-amino acid transmembrane transporter activity#GO:0015179;solute:monoatomic cation symporter activity#GO:0015294;dicarboxylic acid transmembrane transporter activity#GO:0005310;L-glutamate transmembrane transporter activity#GO:0005313;neutral L-amino acid transmembrane transporter activity#GO:0015175;transmembrane transporter activity#GO:0022857 carboxylic acid transport#GO:0046942;transport#GO:0006810;acidic amino acid transport#GO:0015800;organic acid transport#GO:0015849;amino acid transport#GO:0006865;establishment of localization#GO:0051234;cellular process#GO:0009987;nitrogen compound transport#GO:0071705;L-amino acid transport#GO:0015807;dicarboxylic acid transport#GO:0006835;L-glutamate transmembrane transport#GO:0015813;L-glutamate import#GO:0051938;amino acid transmembrane transport#GO:0003333;transmembrane transport#GO:0055085;localization#GO:0051179;L-alpha-amino acid transmembrane transport#GO:1902475;carboxylic acid transmembrane transport#GO:1905039 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 primary active transporter#PC00068 Ionotropic glutamate receptor pathway#P00037>EAAT#P01011;Metabotropic glutamate receptor group III pathway#P00039>EAAT#P01036 HUMAN|HGNC=7695|UniProtKB=O75438 O75438 NDUFB1 PTHR15222:SF4 NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 1 NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 1 catalytic complex#GO:1902494;respiratory chain complex I#GO:0045271;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;membrane protein complex#GO:0098796;membrane#GO:0016020;oxidoreductase complex#GO:1990204;respiratory chain complex#GO:0098803;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 metabolite interconversion enzyme#PC00262;dehydrogenase#PC00092;oxidoreductase#PC00176 HUMAN|HGNC=2893|UniProtKB=Q9UBP4 Q9UBP4 DKK3 PTHR12113:SF8 DICKKOPF3-LIKE 3 DICKKOPF-RELATED PROTEIN 3 molecular function regulator activity#GO:0098772;molecular function inhibitor activity#GO:0140678;signaling receptor inhibitor activity#GO:0030547;protein binding#GO:0005515;signaling receptor regulator activity#GO:0030545;binding#GO:0005488 negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of canonical Wnt signaling pathway#GO:0060828;negative regulation of Wnt signaling pathway#GO:0030178;negative regulation of response to stimulus#GO:0048585;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of signal transduction#GO:0009968;negative regulation of canonical Wnt signaling pathway#GO:0090090;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 membrane traffic protein#PC00150;membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=20188|UniProtKB=Q9NVR5 Q9NVR5 DNAAF2 PTHR22997:SF3 PIH1 DOMAIN-CONTAINING PROTEIN 1 PROTEIN KINTOUN cilium assembly#GO:0060271;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;cell projection organization#GO:0030030;microtubule-based movement#GO:0007018;cell motility#GO:0048870;organelle assembly#GO:0070925;cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;microtubule-based transport#GO:0099111;microtubule bundle formation#GO:0001578;axonemal dynein complex assembly#GO:0070286;localization#GO:0051179;cilium-dependent cell motility#GO:0060285;microtubule cytoskeleton organization#GO:0000226;axoneme assembly#GO:0035082;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection organization#GO:0120036;plasma membrane bounded cell projection assembly#GO:0120031;transport#GO:0006810;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;microtubule-based process#GO:0007017;protein-containing complex organization#GO:0043933 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=12113|UniProtKB=A0A0B4J275 A0A0B4J275 TRAV17 PTHR19433:SF85 T-CELL RECEPTOR ALPHA CHAIN V REGION-RELATED T CELL RECEPTOR ALPHA VARIABLE 17-RELATED response to bacterium#GO:0009617;response to biotic stimulus#GO:0009607;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;response to external stimulus#GO:0009605;response to external biotic stimulus#GO:0043207;response to other organism#GO:0051707 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=28651|UniProtKB=Q9BRX8 Q9BRX8 PRXL2A PTHR28630:SF35 FAMILY NOT NAMED PEROXIREDOXIN-LIKE 2A cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=10327|UniProtKB=P61254 P61254 RPL26 PTHR11143:SF11 60S RIBOSOMAL PROTEIN L26 FAMILY MEMBER LARGE RIBOSOMAL SUBUNIT PROTEIN UL24 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 biosynthetic process#GO:0009058;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;cytoplasmic translation#GO:0002181;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;translation#GO:0006412;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625;cytosol#GO:0005829;ribosome#GO:0005840;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229 ribosomal protein#PC00202;translational protein#PC00263 HUMAN|HGNC=23056|UniProtKB=Q92685 Q92685 ALG3 PTHR12646:SF0 NOT56 - RELATED DOL-P-MAN:MAN(5)GLCNAC(2)-PP-DOL ALPHA-1,3-MANNOSYLTRANSFERASE hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;catalytic activity#GO:0003824;mannosyltransferase activity#GO:0000030;glycosyltransferase activity#GO:0016757 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;biosynthetic process#GO:0009058;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 glycosyltransferase#PC00111 HUMAN|HGNC=7321|UniProtKB=O60682 O60682 MSC PTHR23349:SF62 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST MUSCULIN sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 muscle tissue development#GO:0060537;regulation of RNA metabolic process#GO:0051252;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;skeletal muscle organ development#GO:0060538;animal gross anatomical part developmental process#GO:0160108;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;muscle structure development#GO:0061061;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;animal organ development#GO:0048513;developmental process#GO:0032502;striated muscle tissue development#GO:0014706;muscle organ development#GO:0007517;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;tissue development#GO:0009888;skeletal muscle tissue development#GO:0007519;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 basic helix-loop-helix transcription factor#PC00055;DNA-binding transcription factor#PC00218 HUMAN|HGNC=35458|UniProtKB=A6NHQ2 A6NHQ2 FBLL1 PTHR10335:SF6 RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN RNA 2'-O-METHYLTRANSFERASE FBLL1 protein methyltransferase activity#GO:0008276;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;rRNA methyltransferase activity#GO:0008649;catalytic activity, acting on a protein#GO:0140096;N-methyltransferase activity#GO:0008170;nucleic acid binding#GO:0003676;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;catalytic activity, acting on a rRNA#GO:0140102;RNA binding#GO:0003723;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on RNA#GO:0140098;RNA methyltransferase activity#GO:0008173;histone methyltransferase activity#GO:0042054;binding#GO:0005488;methyltransferase activity#GO:0008168;histone modifying activity#GO:0140993 macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;cellular component organization or biogenesis#GO:0071840;rRNA methylation#GO:0031167;metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule modification#GO:0043412;methylation#GO:0032259;RNA methylation#GO:0001510;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;macromolecule methylation#GO:0043414;RNA modification#GO:0009451;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;rRNA modification#GO:0000154 organelle lumen#GO:0043233;small-subunit processome#GO:0032040;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;preribosome#GO:0030684;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular organelle#GO:0043229;sno(s)RNA-containing ribonucleoprotein complex#GO:0005732;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;nuclear body#GO:0016604;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513 RNA processing factor#PC00147 HUMAN|HGNC=386|UniProtKB=P42330 P42330 AKR1C3 PTHR11732:SF548 ALDO/KETO REDUCTASE ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;monooxygenase activity#GO:0004497;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen#GO:0016709;catalytic activity#GO:0003824;alcohol dehydrogenase (NADP+) activity#GO:0008106;oxidoreductase activity#GO:0016491 steroid metabolic process#GO:0008202;metabolic process#GO:0008152;primary metabolic process#GO:0044238;lipid metabolic process#GO:0006629;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 oxidoreductase#PC00176;reductase#PC00198 HUMAN|HGNC=15631|UniProtKB=Q9NYK1 Q9NYK1 TLR7 PTHR47410:SF2 TOLL-LIKE RECEPTOR 7-RELATED TOLL-LIKE RECEPTOR 7 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;pattern recognition receptor activity#GO:0038187 regulation of gene expression#GO:0010468;pattern recognition receptor signaling pathway#GO:0002221;defense response#GO:0006952;positive regulation of response to biotic stimulus#GO:0002833;response to external stimulus#GO:0009605;positive regulation of gene expression#GO:0010628;regulation of biosynthetic process#GO:0009889;regulation of innate immune response#GO:0045088;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;positive regulation of defense response#GO:0031349;regulation of response to stress#GO:0080134;response to other organism#GO:0051707;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;canonical NF-kappaB signal transduction#GO:0007249;positive regulation of innate immune response#GO:0045089;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;activation of innate immune response#GO:0002218;regulation of cytokine production#GO:0001817;intracellular signal transduction#GO:0035556;response to virus#GO:0009615;cell communication#GO:0007154;positive regulation of biosynthetic process#GO:0009891;regulation of defense response#GO:0031347;regulation of immune response#GO:0050776;regulation of response to biotic stimulus#GO:0002831;response to external biotic stimulus#GO:0043207;intracellular receptor signaling pathway#GO:0030522;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;positive regulation of cytokine production#GO:0001819;regulation of macromolecule metabolic process#GO:0060255;cellular response to stimulus#GO:0051716;innate immune response-activating signaling pathway#GO:0002758;positive regulation of response to external stimulus#GO:0032103;immune response-activating signaling pathway#GO:0002757;regulation of multicellular organismal process#GO:0051239;intracellular signaling cassette#GO:0141124;regulation of response to external stimulus#GO:0032101;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;signal transduction#GO:0007165;response to stress#GO:0006950;positive regulation of immune system process#GO:0002684;response to biotic stimulus#GO:0009607;cytoplasmic pattern recognition receptor signaling pathway#GO:0002753;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;immune system process#GO:0002376;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;immune response-regulating signaling pathway#GO:0002764;positive regulation of multicellular organismal process#GO:0051240;regulation of biological process#GO:0050789;defense response to virus#GO:0051607;toll-like receptor signaling pathway#GO:0002224 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 Toll receptor signaling pathway#P00054>TLR2,4,7#P01351;Toll receptor signaling pathway#P00054>TLR#P01346 HUMAN|HGNC=9544|UniProtKB=Q99436 Q99436 PSMB7 PTHR11599:SF42 PROTEASOME SUBUNIT ALPHA/BETA PROTEASOME SUBUNIT BETA TYPE-7 endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 peptidase complex#GO:1905368;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;proteasome complex#GO:0000502;nucleus#GO:0005634;cytosol#GO:0005829;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;endopeptidase complex#GO:1905369;intracellular organelle#GO:0043229;catalytic complex#GO:1902494 protein modifying enzyme#PC00260;protease#PC00190 Parkinson disease#P00049>20S proteasome#P01227 HUMAN|HGNC=4914|UniProtKB=P61086 P61086 UBE2K PTHR24068:SF147 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2 K catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin conjugating enzyme activity#GO:0061631;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein conjugating enzyme activity#GO:0061650 post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;primary metabolic process#GO:0044238;protein modification process#GO:0036211;cellular process#GO:0009987;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152 ubiquitin-protein ligase#PC00234 Ubiquitin proteasome pathway#P00060>E2#P01491;Ubiquitin proteasome pathway#P00060>E3#P01490 HUMAN|HGNC=10782|UniProtKB=Q05519 Q05519 SRSF11 PTHR32343:SF6 SERINE/ARGININE-RICH SPLICING FACTOR SERINE_ARGININE-RICH SPLICING FACTOR 11 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 RNA splicing factor#PC00148 HUMAN|HGNC=26441|UniProtKB=Q96N87 Q96N87 SLC6A18 PTHR11616:SF109 SODIUM/CHLORIDE DEPENDENT TRANSPORTER INACTIVE SODIUM-DEPENDENT NEUTRAL AMINO ACID TRANSPORTER B(0)AT3 monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;sodium ion transport#GO:0006814;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;amino acid transport#GO:0006865;transport#GO:0006810 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 primary active transporter#PC00068 Adrenaline and noradrenaline biosynthesis#P00001>amine translocator#P00068 HUMAN|HGNC=26052|UniProtKB=Q5TA45 Q5TA45 INTS11 PTHR11203:SF37 CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER INTEGRATOR COMPLEX SUBUNIT 11 catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;RNA endonuclease activity#GO:0004521;catalytic activity, acting on RNA#GO:0140098;RNA nuclease activity#GO:0004540;endonuclease activity#GO:0004519;nuclease activity#GO:0004518 gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;snRNA processing#GO:0016180;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA metabolic process#GO:0016070;snRNA metabolic process#GO:0016073;nucleic acid biosynthetic process#GO:0141187 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 RNA processing factor#PC00147 HUMAN|HGNC=29061|UniProtKB=O60279 O60279 SUSD5 PTHR32493:SF0 SUSHI DOMAIN-CONTAINING PROTEIN 5 SUSHI DOMAIN-CONTAINING PROTEIN 5 cell surface receptor signaling pathway#GO:0007166;Notch signaling pathway#GO:0007219;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 HUMAN|HGNC=28435|UniProtKB=Q5BN46 Q5BN46 PIERCE1 PTHR20899:SF1 PIERCE HOMOLOG PIERCER OF MICROTUBULE WALL 1 PROTEIN HUMAN|HGNC=28715|UniProtKB=Q8IVB5 Q8IVB5 LIX1L PTHR31139:SF3 ECTOPIC P GRANULES PROTEIN 5 HOMOLOG LIX1-LIKE PROTEIN organelle organization#GO:0006996;cellular component organization#GO:0016043;actin filament-based process#GO:0030029;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;actin cytoskeleton organization#GO:0030036;cytoskeleton organization#GO:0007010 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=5466|UniProtKB=P01344 P01344 IGF2 PTHR46886:SF1 INSULIN-LIKE GROWTH FACTOR II INSULIN-LIKE GROWTH FACTOR 2 intercellular signal molecule#PC00207;growth factor#PC00112 Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>Insulin IGF#P00882;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>Insulin IGF#P00896 HUMAN|HGNC=27194|UniProtKB=Q6NVV3 Q6NVV3 NIPAL1 PTHR12570:SF13 DUF803 DOMAIN MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07070)-RELATED MAGNESIUM TRANSPORTER NIPA3 metal ion transport#GO:0030001;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;establishment of localization#GO:0051234;transport#GO:0006810;magnesium ion transport#GO:0015693 membrane#GO:0016020;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258 HUMAN|HGNC=9893|UniProtKB=P28749 P28749 RBL1 PTHR13742:SF20 RETINOBLASTOMA-ASSOCIATED PROTEIN RB -RELATED RETINOBLASTOMA-LIKE PROTEIN 1 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690 cellular developmental process#GO:0048869;negative regulation of cell cycle#GO:0045786;negative regulation of cellular process#GO:0048523;negative regulation of cell cycle process#GO:0010948;developmental process#GO:0032502;negative regulation of mitotic cell cycle phase transition#GO:1901991;regulation of cell cycle process#GO:0010564;biological regulation#GO:0065007;regulation of mitotic cell cycle#GO:0007346;cellular process#GO:0009987;regulation of mitotic cell cycle phase transition#GO:1901990;negative regulation of mitotic cell cycle#GO:0045930;regulation of G1/S transition of mitotic cell cycle#GO:2000045;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of cell cycle G1/S phase transition#GO:1902806;regulation of cell cycle#GO:0051726;negative regulation of cell cycle phase transition#GO:1901988;regulation of cell cycle phase transition#GO:1901987;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789 membraneless organelle#GO:0043228;transcription regulator complex#GO:0005667;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694;chromatin#GO:0000785 chromatin/chromatin-binding, or -regulatory protein#PC00077 p53 pathway feedback loops 2#P04398>Rb#P04654 HUMAN|HGNC=17930|UniProtKB=Q9UJV8 Q9UJV8 PURG PTHR12611:SF3 PUR-TRANSCRIPTIONAL ACTIVATOR PURINE-RICH ELEMENT-BINDING PROTEIN GAMMA transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HUMAN|HGNC=21098|UniProtKB=Q8IWP9 Q8IWP9 CCDC28A PTHR13400:SF3 CHEMOKINE C-C MOTIF RECEPTOR 1 COILED-COIL DOMAIN-CONTAINING PROTEIN 28A developmental process involved in reproduction#GO:0003006;male gamete generation#GO:0048232;gamete generation#GO:0007276;reproductive process#GO:0022414;spermatogenesis#GO:0007283;sexual reproduction#GO:0019953;developmental process#GO:0032502;multicellular organismal reproductive process#GO:0048609 transmembrane signal receptor#PC00197 HUMAN|HGNC=6690|UniProtKB=Q12912 Q12912 IRAG2 PTHR15352:SF3 LYMPHOID-RESTRICTED MEMBRANE PROTEIN, JAW1 INOSITOL 1,4,5-TRIPHOSPHATE RECEPTOR ASSOCIATED 2 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175 scaffold/adaptor protein#PC00226 HUMAN|HGNC=12881|UniProtKB=Q8IZC7 Q8IZC7 ZNF101 PTHR24379:SF70 KRAB AND ZINC FINGER DOMAIN-CONTAINING ZINC FINGER PROTEIN 101 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HUMAN|HGNC=24130|UniProtKB=Q86XR2 Q86XR2 NIBAN3 PTHR14392:SF4 NIBAN FAMILY MEMBER PROTEIN NIBAN 3 HUMAN|HGNC=19085|UniProtKB=O95476 O95476 CTDNEP1 PTHR12210:SF140 DULLARD PROTEIN PHOSPHATASE CTD NUCLEAR ENVELOPE PHOSPHATASE 1 hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721;protein serine/threonine phosphatase activity#GO:0004722;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096 protein phosphatase#PC00195 HUMAN|HGNC=20790|UniProtKB=Q9Y4P1 Q9Y4P1 ATG4B PTHR22624:SF39 CYSTEINE PROTEASE ATG4 CYSTEINE PROTEASE ATG4B hydrolase activity#GO:0016787;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;endopeptidase activity#GO:0004175;cysteine-type endopeptidase activity#GO:0004197;peptidase activity#GO:0008233;protein-phosphatidylethanolamide deconjugating activity#GO:0019786;catalytic activity, acting on a protein#GO:0140096 organelle assembly#GO:0070925;proteolysis#GO:0006508;protein metabolic process#GO:0019538;process utilizing autophagic mechanism#GO:0061919;vacuole organization#GO:0007033;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;catabolic process#GO:0009056;piecemeal microautophagy of the nucleus#GO:0034727;autophagy of mitochondrion#GO:0000422;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;mitophagy#GO:0000423;autophagosome assembly#GO:0000045;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059;autophagosome organization#GO:1905037;autophagy#GO:0006914;protein maturation#GO:0051604;gene expression#GO:0010467;cellular component assembly#GO:0022607;macroautophagy#GO:0016236;biosynthetic process#GO:0009058 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 cysteine protease#PC00081 HUMAN|HGNC=16029|UniProtKB=Q96PS8 Q96PS8 AQP10 PTHR43829:SF13 AQUAPORIN OR AQUAGLYCEROPORIN RELATED AQUAPORIN-10 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;water channel activity#GO:0015250;water transmembrane transporter activity#GO:0005372;passive transmembrane transporter activity#GO:0022803;carbohydrate transmembrane transporter activity#GO:0015144;channel activity#GO:0015267 carbohydrate transmembrane transport#GO:0034219;cellular process#GO:0009987;water transport#GO:0006833;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;organic hydroxy compound transport#GO:0015850;fluid transport#GO:0042044;carbohydrate transport#GO:0008643;transport#GO:0006810 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;cell periphery#GO:0071944;basal plasma membrane#GO:0009925;membrane#GO:0016020;basolateral plasma membrane#GO:0016323;basal part of cell#GO:0045178 transporter#PC00227 HUMAN|HGNC=11910|UniProtKB=Q93038 Q93038 TNFRSF25 PTHR47220:SF1 TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 25 TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 25 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=856|UniProtKB=P21283 P21283 ATP6V1C1 PTHR10137:SF5 V-TYPE PROTON ATPASE SUBUNIT C V-TYPE PROTON ATPASE SUBUNIT C 1 active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399;monoatomic ion transmembrane transporter activity#GO:0015075;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;proton transmembrane transporter activity#GO:0015078;monoatomic cation transmembrane transporter activity#GO:0008324;ATP-dependent activity#GO:0140657;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATPase-coupled transmembrane transporter activity#GO:0042626 proton-transporting two-sector ATPase complex#GO:0016469;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;proton-transporting V-type ATPase complex#GO:0033176;transporter complex#GO:1990351;vacuolar membrane#GO:0005774;membrane#GO:0016020;cytoplasm#GO:0005737;vacuole#GO:0005773;protein-containing complex#GO:0032991;ATPase complex#GO:1904949;intracellular organelle#GO:0043229;vacuolar proton-transporting V-type ATPase complex#GO:0016471;catalytic complex#GO:1902494;ATPase dependent transmembrane transport complex#GO:0098533;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transmembrane transporter complex#GO:1902495;cation-transporting ATPase complex#GO:0090533;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;vacuolar proton-transporting V-type ATPase, V1 domain#GO:0000221;organelle#GO:0043226 ATP synthase#PC00002 HUMAN|HGNC=18828|UniProtKB=Q9Y375 Q9Y375 NDUFAF1 PTHR13194:SF23 COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30 COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30, MITOCHONDRIAL cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;mitochondrial respiratory chain complex I assembly#GO:0032981;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;cellular component assembly#GO:0022607;mitochondrial respiratory chain complex assembly#GO:0033108;mitochondrion organization#GO:0007005;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;NADH dehydrogenase complex assembly#GO:0010257 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=23400|UniProtKB=Q9BY50 Q9BY50 SEC11C PTHR10806:SF12 SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11 SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11C catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233 metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467 endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;endopeptidase complex#GO:1905369;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum protein-containing complex#GO:0140534;organelle membrane#GO:0031090;membrane#GO:0016020;peptidase complex#GO:1905368;cytoplasm#GO:0005737;endomembrane system#GO:0012505;protein-containing complex#GO:0032991 serine protease#PC00203 Vasopressin synthesis#P04395>Signal Peptidase#P04589;Endothelin signaling pathway#P00019>signal peptidase#P00573 HUMAN|HGNC=11477|UniProtKB=Q15528 Q15528 MED22 PTHR12434:SF6 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22 intracellular anatomical structure#GO:0005622;mediator complex#GO:0016592;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634 RNA metabolism protein#PC00031;general transcription factor#PC00259 HUMAN|HGNC=33733|UniProtKB=A6NGA9 A6NGA9 TMEM202 PTHR10671:SF42 EPITHELIAL MEMBRANE PROTEIN-RELATED TRANSMEMBRANE PROTEIN 202 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cytoskeletal protein#PC00085 HUMAN|HGNC=956|UniProtKB=Q9UMQ3 Q9UMQ3 BARX2 PTHR24330:SF7 HOMEOBOX PROTEIN BARH-LIKE HOMEOBOX PROTEIN BARH-LIKE 2 transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=17345|UniProtKB=Q8N4E7 Q8N4E7 FTMT PTHR11431:SF30 FERRITIN FERRITIN, MITOCHONDRIAL transition metal ion binding#GO:0046914;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;cation binding#GO:0043169;metal ion binding#GO:0046872;ferrous iron binding#GO:0008198;iron ion binding#GO:0005506 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 storage protein#PC00210 HUMAN|HGNC=25496|UniProtKB=Q9NW81 Q9NW81 DMAC2 PTHR13318:SF186 PARTNER OF PAIRED, ISOFORM B-RELATED DISTAL MEMBRANE-ARM ASSEMBLY COMPLEX PROTEIN 2 organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cellular component assembly#GO:0022607;proteasomal protein catabolic process#GO:0010498;mitochondrial respiratory chain complex assembly#GO:0033108;mitochondrion organization#GO:0007005;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;NADH dehydrogenase complex assembly#GO:0010257;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;mitochondrial respiratory chain complex I assembly#GO:0032981;modification-dependent protein catabolic process#GO:0019941;protein-containing complex assembly#GO:0065003;catabolic process#GO:0009056;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538 ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;intracellular protein-containing complex#GO:0140535;SCF ubiquitin ligase complex#GO:0019005;cullin-RING ubiquitin ligase complex#GO:0031461;transferase complex#GO:1990234;catalytic complex#GO:1902494 HUMAN|HGNC=9990|UniProtKB=P47804 P47804 RGR PTHR24240:SF90 OPSIN RPE-RETINAL G PROTEIN-COUPLED RECEPTOR signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 response to external stimulus#GO:0009605;cellular response to abiotic stimulus#GO:0071214;signal transduction#GO:0007165;response to radiation#GO:0009314;cellular process#GO:0009987;cellular response to light stimulus#GO:0071482;detection of stimulus#GO:0051606;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to abiotic stimulus#GO:0009628;signaling#GO:0023052;cellular response to radiation#GO:0071478;response to light stimulus#GO:0009416;response to stimulus#GO:0050896;cellular response to environmental stimulus#GO:0104004;regulation of cellular process#GO:0050794 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021 HUMAN|HGNC=29400|UniProtKB=Q96PX6 Q96PX6 CCDC85A PTHR13546:SF13 RE60986P COILED-COIL DOMAIN-CONTAINING PROTEIN 85A HUMAN|HGNC=30559|UniProtKB=Q7L4I2 Q7L4I2 RSRC2 PTHR22426:SF2 ARGININE_SERINE-RICH COILED-COIL PROTEIN 2 ARGININE_SERINE-RICH COILED-COIL PROTEIN 2 HUMAN|HGNC=8793|UniProtKB=O60658 O60658 PDE8A PTHR11347:SF85 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE HIGH AFFINITY CAMP-SPECIFIC AND IBMX-INSENSITIVE 3',5'-CYCLIC PHOSPHODIESTERASE 8A hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;cyclic-nucleotide phosphodiesterase activity#GO:0004112;hydrolase activity#GO:0016787;phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578 regulation of response to stimulus#GO:0048583;regulation of MAPK cascade#GO:0043408;positive regulation of intracellular signal transduction#GO:1902533;negative regulation of cellular process#GO:0048523;positive regulation of MAPK cascade#GO:0043410;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;negative regulation of signal transduction#GO:0009968;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of response to stimulus#GO:0048585;positive regulation of response to stimulus#GO:0048584;regulation of ERK1 and ERK2 cascade#GO:0070372;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648;cellular response to growth factor stimulus#GO:0071363;positive regulation of signaling#GO:0023056;negative regulation of intracellular signal transduction#GO:1902532;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;positive regulation of signal transduction#GO:0009967;negative regulation of biological process#GO:0048519;positive regulation of ERK1 and ERK2 cascade#GO:0070374;regulation of cell communication#GO:0010646;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;response to growth factor#GO:0070848;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495 hydrolase#PC00121;phosphodiesterase#PC00185 HUMAN|HGNC=15479|UniProtKB=Q8TC27 Q8TC27 ADAM32 PTHR11905:SF24 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 32 metalloendopeptidase activity#GO:0004222;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 cell-cell recognition#GO:0009988;macromolecule metabolic process#GO:0043170;multicellular organism development#GO:0007275;animal organ development#GO:0048513;development of primary sexual characteristics#GO:0045137;developmental process#GO:0032502;male sex differentiation#GO:0046661;metabolic process#GO:0008152;development of primary male sexual characteristics#GO:0046546;sperm-egg recognition#GO:0035036;gonad development#GO:0008406;multicellular organismal process#GO:0032501;male gonad development#GO:0008584;cellular process#GO:0009987;sex differentiation#GO:0007548;single fertilization#GO:0007338;system development#GO:0048731;reproductive system development#GO:0061458;protein metabolic process#GO:0019538;anatomical structure development#GO:0048856;binding of sperm to zona pellucida#GO:0007339;cell adhesion#GO:0007155;sexual reproduction#GO:0019953;cell recognition#GO:0008037;proteolysis#GO:0006508;animal gross anatomical part developmental process#GO:0160108;fertilization#GO:0009566;reproductive process#GO:0022414;reproductive structure development#GO:0048608;primary metabolic process#GO:0044238;developmental process involved in reproduction#GO:0003006 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 protease#PC00190;metalloprotease#PC00153 HUMAN|HGNC=11875|UniProtKB=P42166 P42166 TMPO PTHR12019:SF24 LAMINA-ASSOCIATED POLYPEPTIDE THYMOPOIETIN LAMINA-ASSOCIATED POLYPEPTIDE 2, ISOFORM ALPHA intercellular signal molecule#PC00207;peptide hormone#PC00179 HUMAN|HGNC=23533|UniProtKB=Q5VWI1 Q5VWI1 TCERG1L PTHR15377:SF5 TRANSCRIPTION ELONGATION REGULATOR 1 TRANSCRIPTION ELONGATION REGULATOR 1-LIKE PROTEIN protein binding#GO:0005515;binding#GO:0005488;transcription coregulator activity#GO:0003712;enzyme binding#GO:0019899;transcription regulator activity#GO:0140110;RNA polymerase binding#GO:0070063 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 general transcription factor#PC00259 HUMAN|HGNC=168|UniProtKB=P42025 P42025 ACTR1B PTHR11937:SF195 ACTIN BETA-CENTRACTIN structural molecule activity#GO:0005198;protein-membrane adaptor activity#GO:0043495;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;structural constituent of cytoskeleton#GO:0005200;cytoskeletal adaptor activity#GO:0008093 microtubule-based transport#GO:0099111;organelle localization#GO:0051640;cellular localization#GO:0051641;localization#GO:0051179;nuclear migration#GO:0007097;establishment of organelle localization#GO:0051656;microtubule-based movement#GO:0007018;transport#GO:0006810;intracellular transport#GO:0046907;microtubule-based process#GO:0007017;transport along microtubule#GO:0010970;establishment of localization#GO:0051234;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;organelle transport along microtubule#GO:0072384;cytoskeleton-dependent intracellular transport#GO:0030705 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;actin cytoskeleton#GO:0015629;microtubule cytoskeleton#GO:0015630 actin and actin related protein#PC00039 Nicotinic acetylcholine receptor signaling pathway#P00044>Actin#P01090 HUMAN|HGNC=277|UniProtKB=P35348 P35348 ADRA1A PTHR24248:SF16 ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR ALPHA-1A ADRENERGIC RECEPTOR molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;G protein-coupled amine receptor activity#GO:0008227 adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;cellular process#GO:0009987;signal transduction#GO:0007165;cell communication#GO:0007154;regulation of biological quality#GO:0065008;adrenergic receptor signaling pathway#GO:0071875;positive regulation of cytosolic calcium ion concentration#GO:0007204;G protein-coupled receptor signaling pathway#GO:0007186;phospholipase C-activating G protein-coupled receptor signaling pathway#GO:0007200;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;Alpha adrenergic receptor signaling pathway#P00002>Alpha1A/1B/1C#P00078 HUMAN|HGNC=18007|UniProtKB=Q9H4G4 Q9H4G4 GLIPR2 PTHR10334:SF581 CYSTEINE-RICH SECRETORY PROTEIN-RELATED GOLGI-ASSOCIATED PLANT PATHOGENESIS-RELATED PROTEIN 1 positive regulation of cell differentiation#GO:0045597;regulation of cell differentiation#GO:0045595;positive regulation of developmental process#GO:0051094;regulation of cellular process#GO:0050794;regulation of multicellular organismal process#GO:0051239;regulation of developmental process#GO:0050793;biological regulation#GO:0065007;positive regulation of multicellular organismal process#GO:0051240;positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789;positive regulation of cellular process#GO:0048522 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090 HUMAN|HGNC=24868|UniProtKB=Q8WZA9 Q8WZA9 IRGQ PTHR19364:SF2 IMMUNITY-RELATED GTPASE FAMILY Q PROTEIN IMMUNITY-RELATED GTPASE FAMILY Q PROTEIN HUMAN|HGNC=11721|UniProtKB=Q96PL2 Q96PL2 TECTB PTHR14002:SF13 ENDOGLIN/TGF-BETA RECEPTOR TYPE III BETA-TECTORIN structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 cellular anatomical structure#GO:0110165;cell surface#GO:0009986;extracellular region#GO:0005576 transmembrane signal receptor#PC00197 HUMAN|HGNC=5588|UniProtKB=P01764 P01764 IGHV3-23 PTHR23266:SF372 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 3-23-RELATED antigen binding#GO:0003823;binding#GO:0005488 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449;immune effector process#GO:0002252;immune system process#GO:0002376;adaptive immune response#GO:0002250;response to stimulus#GO:0050896;immune response#GO:0006955 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=15654|UniProtKB=Q96SQ9 Q96SQ9 CYP2S1 PTHR24300:SF23 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 2S1 heme binding#GO:0020037;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;monooxygenase activity#GO:0004497;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen#GO:0016712;oxidoreductase activity#GO:0016491;binding#GO:0005488;tetrapyrrole binding#GO:0046906 xenobiotic metabolic process#GO:0006805;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;arachidonate metabolic process#GO:0019369;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;monocarboxylic acid metabolic process#GO:0032787;olefinic compound metabolic process#GO:0120254;oxoacid metabolic process#GO:0043436;response to xenobiotic stimulus#GO:0009410;cellular response to chemical stimulus#GO:0070887;cellular response to xenobiotic stimulus#GO:0071466;icosanoid metabolic process#GO:0006690;response to chemical#GO:0042221;cellular process#GO:0009987;long-chain fatty acid metabolic process#GO:0001676;lipid metabolic process#GO:0006629;unsaturated fatty acid metabolic process#GO:0033559;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 oxygenase#PC00177;oxidoreductase#PC00176 HUMAN|HGNC=2962|UniProtKB=Q8NCM8 Q8NCM8 DYNC2H1 PTHR10676:SF352 DYNEIN HEAVY CHAIN FAMILY PROTEIN CYTOPLASMIC DYNEIN 2 HEAVY CHAIN 1 cytoskeletal motor activity#GO:0003774;isomerase activity#GO:0016853;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543;protein binding#GO:0005515;microtubule motor activity#GO:0003777;binding#GO:0005488;polypeptide conformation or assembly isomerase activity#GO:0120544;ATP-dependent activity#GO:0140657 cellular component organization#GO:0016043;cilium assembly#GO:0060271;cell projection organization#GO:0030030;microtubule-based movement#GO:0007018;intraciliary retrograde transport#GO:0035721;cell motility#GO:0048870;intraciliary transport#GO:0042073;organelle assembly#GO:0070925;cilium or flagellum-dependent cell motility#GO:0001539;cilium movement#GO:0003341;microtubule-based transport#GO:0099111;cilium-dependent cell motility#GO:0060285;localization#GO:0051179;cellular localization#GO:0051641;cilium organization#GO:0044782;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cilium movement involved in cell motility#GO:0060294;cell projection assembly#GO:0030031;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;cellular component assembly#GO:0022607;cytoskeleton-dependent intracellular transport#GO:0030705;plasma membrane bounded cell projection organization#GO:0120036;plasma membrane bounded cell projection assembly#GO:0120031;intracellular transport#GO:0046907;transport#GO:0006810;cellular component organization or biogenesis#GO:0071840;transport along microtubule#GO:0010970;establishment of localization#GO:0051234;microtubule-based process#GO:0007017 dynein complex#GO:0030286;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;motile cilium#GO:0031514;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cilium#GO:0005929;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;9+2 motile cilium#GO:0097729;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;axoneme#GO:0005930;microtubule cytoskeleton#GO:0015630;cytoplasmic dynein complex#GO:0005868;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;ciliary plasm#GO:0097014;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228 microtubule or microtubule-binding cytoskeletal protein#PC00157;microtubule binding motor protein#PC00156 Huntington disease#P00029>Dynein complex#P00774 HUMAN|HGNC=14121|UniProtKB=Q9Y2Y1 Q9Y2Y1 POLR3K PTHR11239:SF12 DNA-DIRECTED RNA POLYMERASE DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10 catalytic activity, acting on RNA#GO:0140098;catalytic activity#GO:0003824;transferase activity#GO:0016740;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772 DNA-templated transcription termination#GO:0006353;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;transcription by RNA polymerase III#GO:0006383;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070 RNA polymerase III complex#GO:0005666;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991 DNA-directed RNA polymerase#PC00019 HUMAN|HGNC=18710|UniProtKB=Q8N0V4 Q8N0V4 LGI2 PTHR24367:SF21 LEUCINE-RICH REPEAT-CONTAINING PROTEIN LEUCINE-RICH REPEAT LGI FAMILY MEMBER 2 cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;developmental process#GO:0032502;nervous system development#GO:0007399;cellular component assembly#GO:0022607;multicellular organismal process#GO:0032501;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;system development#GO:0048731;anatomical structure development#GO:0048856;synapse organization#GO:0050808;animal gross anatomical part developmental process#GO:0160108;cell junction organization#GO:0034330;synapse assembly#GO:0007416;cell junction assembly#GO:0034329;cellular component organization#GO:0016043 HUMAN|HGNC=13797|UniProtKB=Q9BXM0 Q9BXM0 PRX PTHR23348:SF42 PERIAXIN/AHNAK PERIAXIN regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;cellular process#GO:0009987;multicellular organismal process#GO:0032501;glial cell differentiation#GO:0010001;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;biological regulation#GO:0065007;regulation of RNA splicing#GO:0043484;nervous system development#GO:0007399;developmental process#GO:0032502;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;gliogenesis#GO:0042063;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;myelination#GO:0042552;peripheral nervous system development#GO:0007422;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;cell development#GO:0048468;animal gross anatomical part developmental process#GO:0160108;plasma membrane organization#GO:0007009;anatomical structure development#GO:0048856;system development#GO:0048731 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634 HUMAN|HGNC=17284|UniProtKB=Q9NUX5 Q9NUX5 POT1 PTHR14513:SF0 PROTECTION OF TELOMERES 1 PROTECTION OF TELOMERES PROTEIN 1 telomeric repeat DNA binding#GO:0042162;molecular function regulator activity#GO:0098772;sequence-specific DNA binding#GO:0043565;enzyme inhibitor activity#GO:0004857;molecular function inhibitor activity#GO:0140678;DNA binding#GO:0003677;enzyme regulator activity#GO:0030234;single-stranded DNA binding#GO:0003697;binding#GO:0005488;nucleic acid binding#GO:0003676 telomere organization#GO:0032200;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;regulation of DNA metabolic process#GO:0051052;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular component organization#GO:0051128;DNA metabolic process#GO:0006259;regulation of chromosome organization#GO:0033044;metabolic process#GO:0008152;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;chromosome organization#GO:0051276;regulation of telomere maintenance#GO:0032204;telomere maintenance#GO:0000723;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of telomere maintenance via telomere lengthening#GO:1904356;telomere capping#GO:0016233;organelle organization#GO:0006996;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;protein-DNA complex#GO:0032993;chromosome#GO:0005694;intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687;membrane-bounded organelle#GO:0043227;chromosome, telomeric repeat region#GO:0140445;nuclear telomere cap complex#GO:0000783;intracellular organelle#GO:0043229;chromosome, telomeric region#GO:0000781;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513 DNA metabolism protein#PC00009 HUMAN|HGNC=11149|UniProtKB=O75324 O75324 SNN PTHR28564:SF1 STANNIN STANNIN cellular anatomical structure#GO:0110165;membrane#GO:0016020 HUMAN|HGNC=19661|UniProtKB=Q59H18 Q59H18 TNNI3K PTHR24166:SF62 ROLLING PEBBLES, ISOFORM B SERINE_THREONINE-PROTEIN KINASE TNNI3K scaffold/adaptor protein#PC00226 HUMAN|HGNC=18104|UniProtKB=Q8NES8 Q8NES8 DEFB124 PTHR47897:SF1 BETA-DEFENSIN 124 BETA-DEFENSIN 124 response to stress#GO:0006950;response to biotic stimulus#GO:0009607;defense response to symbiont#GO:0140546;immune response#GO:0006955;defense response to other organism#GO:0098542;response to stimulus#GO:0050896;response to other organism#GO:0051707;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;immune system process#GO:0002376;innate immune response#GO:0045087;defense response#GO:0006952;response to external stimulus#GO:0009605 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 antimicrobial response protein#PC00051 HUMAN|HGNC=30390|UniProtKB=Q7Z614 Q7Z614 SNX20 PTHR20939:SF1 SORTING NEXIN 20, 21 SORTING NEXIN-20 phospholipid binding#GO:0005543;binding#GO:0005488;lipid binding#GO:0008289;phosphatidylinositol phosphate binding#GO:1901981 vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endosome membrane#GO:0010008;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;early endosome#GO:0005769;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;vesicle membrane#GO:0012506;membrane#GO:0016020;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;early endosome membrane#GO:0031901;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588 scaffold/adaptor protein#PC00226 HUMAN|HGNC=7857|UniProtKB=P30419 P30419 NMT1 PTHR11377:SF7 N-MYRISTOYL TRANSFERASE GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE 1 acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746 intracellular protein localization#GO:0008104;cellular localization#GO:0051641;localization#GO:0051179;cellular process#GO:0009987;localization within membrane#GO:0051668;macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 transferase#PC00220 HUMAN|HGNC=1511|UniProtKB=P55211 P55211 CASP9 PTHR10454:SF157 CASPASE CASPASE-9 endopeptidase activity#GO:0004175;cysteine-type endopeptidase activity#GO:0004197;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234 positive regulation of apoptotic process#GO:0043065;apoptotic signaling pathway#GO:0097190;DNA damage response#GO:0006974;regulation of apoptotic process#GO:0042981;positive regulation of neuron apoptotic process#GO:0043525;biological regulation#GO:0065007;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;regulation of neuron apoptotic process#GO:0043523;intrinsic apoptotic signaling pathway in response to DNA damage#GO:0008630;response to stress#GO:0006950;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;intrinsic apoptotic signaling pathway#GO:0097193;cellular response to stress#GO:0033554;signaling#GO:0023052;response to stimulus#GO:0050896;positive regulation of programmed cell death#GO:0043068;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;apoptotic process#GO:0006915;cellular response to stimulus#GO:0051716;cell death#GO:0008219;regulation of programmed cell death#GO:0043067;programmed cell death#GO:0012501 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 protease#PC00190;protein modifying enzyme#PC00260 PI3 kinase pathway#P00048>Caspase-9#P01197;FAS signaling pathway#P00020>Pro-Caspase9#P00603;VEGF signaling pathway#P00056>Caspase9#P01410;FAS signaling pathway#P00020>Caspase9#P00593;Angiogenesis#P00005>Caspase 9#P00216;Apoptosis signaling pathway#P00006>Caspase 9#P00298 HUMAN|HGNC=6563|UniProtKB=P17931 P17931 LGALS3 PTHR11346:SF26 GALECTIN GALECTIN-3 protein binding#GO:0005515;extracellular matrix binding#GO:0050840;carbohydrate binding#GO:0030246;protein-containing complex binding#GO:0044877;oligosaccharide binding#GO:0070492;binding#GO:0005488;laminin binding#GO:0043236 regulation of localization#GO:0032879;regulation of transport#GO:0051049;neutrophil chemotaxis#GO:0030593;regulation of endocytosis#GO:0030100;regulation of apoptotic process#GO:0042981;taxis#GO:0042330;response to chemical#GO:0042221;neutrophil migration#GO:1990266;granulocyte migration#GO:0097530;negative regulation of signal transduction#GO:0009968;positive chemotaxis#GO:0050918;positive regulation of transport#GO:0051050;negative regulation of programmed cell death#GO:0043069;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;negative regulation of cell communication#GO:0010648;cellular response to chemical stimulus#GO:0070887;immune system process#GO:0002376;negative regulation of signaling#GO:0023057;mononuclear cell migration#GO:0071674;regulation of signaling#GO:0023051;regulation of cellular component organization#GO:0051128;granulocyte chemotaxis#GO:0071621;response to stimulus#GO:0050896;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;regulation of biological process#GO:0050789;response to external stimulus#GO:0009605;myeloid leukocyte migration#GO:0097529;leukocyte chemotaxis#GO:0030595;leukocyte migration#GO:0050900;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of monoatomic ion transport#GO:0043269;negative regulation of apoptotic process#GO:0043066;negative regulation of response to stimulus#GO:0048585;cell migration#GO:0016477;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of calcium ion transport#GO:0051924;negative regulation of extrinsic apoptotic signaling pathway#GO:2001237;macrophage chemotaxis#GO:0048246;cell chemotaxis#GO:0060326;chemotaxis#GO:0006935;negative regulation of apoptotic signaling pathway#GO:2001234;regulation of apoptotic signaling pathway#GO:2001233;negative regulation of transport#GO:0051051;regulation of metal ion transport#GO:0010959;cell motility#GO:0048870;regulation of cellular process#GO:0050794;locomotion#GO:0040011;regulation of cell communication#GO:0010646;regulation of extrinsic apoptotic signaling pathway#GO:2001236;negative regulation of cellular component organization#GO:0051129;cellular response to stimulus#GO:0051716 membrane#GO:0016020;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;nucleus#GO:0005634;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;plasma membrane#GO:0005886;extracellular region#GO:0005576;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 extracellular matrix protein#PC00102 HUMAN|HGNC=2440|UniProtKB=P0DML2 P0DML2 CSH1 PTHR11417:SF67 SOMATOTROPIN,PROLACTIN CHORIONIC SOMATOMAMMOTROPIN HORMONE 1-RELATED hormone receptor binding#GO:0051427;binding#GO:0005488;cytokine receptor binding#GO:0005126;signaling receptor binding#GO:0005102;hormone activity#GO:0005179;molecular function activator activity#GO:0140677;protein binding#GO:0005515;growth factor activity#GO:0008083;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546 regulation of signaling#GO:0023051;response to oxygen-containing compound#GO:1901700;animal gross anatomical part developmental process#GO:0160108;cellular response to chemical stimulus#GO:0070887;positive regulation of signaling#GO:0023056;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;signaling#GO:0023052;cellular response to hormone stimulus#GO:0032870;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;cell surface receptor signaling pathway#GO:0007166;animal organ development#GO:0048513;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;response to hormone#GO:0009725;response to chemical#GO:0042221;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of receptor signaling pathway via JAK-STAT#GO:0046427;response to nitrogen compound#GO:1901698;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;cellular response to peptide hormone stimulus#GO:0071375;regulation of receptor signaling pathway via STAT#GO:1904892;regulation of cell communication#GO:0010646;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of receptor signaling pathway via JAK-STAT#GO:0046425;regulation of response to stimulus#GO:0048583;developmental process#GO:0032502;positive regulation of cellular process#GO:0048522;response to nutrient levels#GO:0031667;response to peptide hormone#GO:0043434;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;cellular response to nitrogen compound#GO:1901699;positive regulation of response to stimulus#GO:0048584 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 peptide hormone#PC00179 HUMAN|HGNC=28467|UniProtKB=Q9BTP7 Q9BTP7 FAAP24 PTHR31786:SF2 FANCONI ANEMIA CORE COMPLEX-ASSOCIATED PROTEIN 24 FANCONI ANEMIA CORE COMPLEX-ASSOCIATED PROTEIN 24 binding#GO:0005488;chromatin binding#GO:0003682 organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Fanconi anaemia nuclear complex#GO:0043240;intracellular organelle#GO:0043229 HUMAN|HGNC=8926|UniProtKB=P46019 P46019 PHKA2 PTHR10749:SF5 PHOSPHORYLASE B KINASE REGULATORY SUBUNIT PHOSPHORYLASE B KINASE REGULATORY SUBUNIT ALPHA, LIVER ISOFORM cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;transferase complex, transferring phosphorus-containing groups#GO:0061695;transferase complex#GO:1990234;catalytic complex#GO:1902494;serine/threonine protein kinase complex#GO:1902554;intracellular anatomical structure#GO:0005622;protein kinase complex#GO:1902911 kinase activator#PC00138 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Phosphorylase b kinase#P00716 HUMAN|HGNC=25799|UniProtKB=Q8N442 Q8N442 GUF1 PTHR43512:SF7 TRANSLATION FACTOR GUF1-RELATED TRANSLATION FACTOR GUF1, MITOCHONDRIAL binding#GO:0005488;ribonucleoprotein complex binding#GO:0043021;protein-containing complex binding#GO:0044877;ribosome binding#GO:0043022 regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;regulation of macromolecule biosynthetic process#GO:0010556;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604;biological regulation#GO:0065007;post-transcriptional regulation of gene expression#GO:0010608;regulation of biosynthetic process#GO:0009889;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of protein metabolic process#GO:0051247;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;positive regulation of translation#GO:0045727 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 translation initiation factor#PC00224 HUMAN|HGNC=16438|UniProtKB=Q8NBS3 Q8NBS3 SLC4A11 PTHR11453:SF127 ANION EXCHANGE PROTEIN SOLUTE CARRIER FAMILY 4 MEMBER 11 bicarbonate transmembrane transporter activity#GO:0015106;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;homeostatic process#GO:0042592;transport#GO:0006810;chemical homeostasis#GO:0048878;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;cell periphery#GO:0071944;basal plasma membrane#GO:0009925;membrane#GO:0016020;basal part of cell#GO:0045178;basolateral plasma membrane#GO:0016323 secondary carrier transporter#PC00258 HUMAN|HGNC=18785|UniProtKB=P56182 P56182 RRP1 PTHR13026:SF1 NNP-1 PROTEIN NOVEL NUCLEAR PROTEIN 1 NOP52 RIBOSOMAL RNA PROCESSING PROTEIN 1 HOMOLOG A transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;transcription coactivator activity#GO:0003713 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 chromosome#GO:0005694;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=31810|UniProtKB=A6NGE4 A6NGE4 DCAF8L1 PTHR15574:SF29 WD REPEAT DOMAIN-CONTAINING FAMILY DDB1- AND CUL4-ASSOCIATED FACTOR 8-LIKE PROTEIN 1 intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;ubiquitin ligase complex#GO:0000151;Cul4-RING E3 ubiquitin ligase complex#GO:0080008;catalytic complex#GO:1902494;transferase complex#GO:1990234;cytoplasm#GO:0005737;cullin-RING ubiquitin ligase complex#GO:0031461;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=24614|UniProtKB=P57772 P57772 EEFSEC PTHR43721:SF11 ELONGATION FACTOR TU-RELATED SELENOCYSTEINE-SPECIFIC ELONGATION FACTOR translation factor activity#GO:0180051;translation elongation factor activity#GO:0003746 protein metabolic process#GO:0019538;translation#GO:0006412;regulation of macromolecule metabolic process#GO:0060255;protein biosynthetic process#GO:0160307;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;primary metabolic process#GO:0044238;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;translational elongation#GO:0006414;metabolic process#GO:0008152;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of protein metabolic process#GO:0051246 translation elongation factor#PC00222 HUMAN|HGNC=28522|UniProtKB=Q8N6D2 Q8N6D2 RNF182 PTHR46675:SF2 E3 UBIQUITIN-PROTEIN LIGASE RNF182 E3 UBIQUITIN-PROTEIN LIGASE RNF182 catalytic activity, acting on a protein#GO:0140096;ubiquitin-protein transferase activity#GO:0004842;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787 post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;protein modification process#GO:0036211;primary metabolic process#GO:0044238;cellular process#GO:0009987;protein modification by small protein conjugation#GO:0032446;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=25481|UniProtKB=O75648 O75648 TRMU PTHR11933:SF9 TRNA 5-METHYLAMINOMETHYL-2-THIOURIDYLATE -METHYLTRANSFERASE MITOCHONDRIAL TRNA-SPECIFIC 2-THIOURIDYLASE 1 catalytic activity, acting on RNA#GO:0140098;transferase activity, transferring sulphur-containing groups#GO:0016782;catalytic activity, acting on a tRNA#GO:0140101;sulfurtransferase activity#GO:0016783;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;transferase activity#GO:0016740 tRNA modification#GO:0006400;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;tRNA wobble base modification#GO:0002097;tRNA wobble uridine modification#GO:0002098;tRNA wobble position uridine thiolation#GO:0002143;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;tRNA thio-modification#GO:0034227;mitochondrial RNA metabolic process#GO:0000959;mitochondrial gene expression#GO:0140053;mitochondrial RNA modification#GO:1900864;RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;mitochondrial RNA processing#GO:0000963;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152 mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 RNA methyltransferase#PC00033 HUMAN|HGNC=926|UniProtKB=O60512 O60512 B4GALT3 PTHR19300:SF33 BETA-1,4-GALACTOSYLTRANSFERASE BETA-1,4-GALACTOSYLTRANSFERASE 3 transferase activity#GO:0016740;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;glycosyltransferase activity#GO:0016757;galactosyltransferase activity#GO:0008378 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 metabolite interconversion enzyme#PC00262;glycosyltransferase#PC00111 HUMAN|HGNC=30449|UniProtKB=Q7Z6K3 Q7Z6K3 PTAR1 PTHR11129:SF3 PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT PROTEIN PRENYLTRANSFERASE ALPHA SUBUNIT REPEAT-CONTAINING PROTEIN 1 catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;prenyltransferase activity#GO:0004659;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 acyltransferase#PC00042;transferase#PC00220 HUMAN|HGNC=19691|UniProtKB=Q9BV79 Q9BV79 MECR PTHR43981:SF9 ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL small molecule metabolic process#GO:0044281;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;cellular process#GO:0009987;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;fatty acid metabolic process#GO:0006631;lipid metabolic process#GO:0006629 mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 metabolite interconversion enzyme#PC00262;reductase#PC00198 HUMAN|HGNC=18936|UniProtKB=Q8IUB9 Q8IUB9 KRTAP19-1 PTHR38140:SF6 KERATIN-ASSOCIATED PROTEIN 19-3-RELATED KERATIN-ASSOCIATED PROTEIN 19-1 structural protein#PC00211 HUMAN|HGNC=26906|UniProtKB=Q5K4E3 Q5K4E3 PRSS36 PTHR24276:SF62 POLYSERASE-RELATED POLYSERASE-2 hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;serine-type peptidase activity#GO:0008236;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity#GO:0003824 protein modifying enzyme#PC00260;serine protease#PC00203 HUMAN|HGNC=18603|UniProtKB=Q9BXS0 Q9BXS0 COL25A1 PTHR37456:SF3 SI:CH211-266K2.1 COLLAGEN ALPHA-1(XXV) CHAIN binding#GO:0005488;peptide binding#GO:0042277 HUMAN|HGNC=3597|UniProtKB=P62861 P62861 FAU PTHR10666:SF471 UBIQUITIN UBIQUITIN-LIKE FUBI-RIBOSOMAL PROTEIN ES30 FUSION PROTEIN structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;cellular process#GO:0009987;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;protein modification by small protein conjugation or removal#GO:0070647;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;catabolic process#GO:0009056;primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941 cytosolic ribosome#GO:0022626;cytosol#GO:0005829;nucleus#GO:0005634;ribosome#GO:0005840;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=43623|UniProtKB=A0A1W2PQC6 A0A1W2PQC6 SSU72L4 PTHR20383:SF10 RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE SSU72 LIKE PROTEIN 1-RELATED phosphoprotein phosphatase activity#GO:0004721;protein serine/threonine phosphatase activity#GO:0004722;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 mRNA processing#GO:0006397;DNA-templated transcription termination#GO:0006353;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;mRNA 3'-end processing#GO:0031124;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;termination of RNA polymerase II transcription#GO:0006369;transcription by RNA polymerase II#GO:0006366;RNA 3'-end processing#GO:0031123;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;DNA-templated transcription#GO:0006351;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070 organelle#GO:0043226;cellular anatomical structure#GO:0110165;mRNA cleavage factor complex#GO:0005849;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mRNA cleavage and polyadenylation specificity factor complex#GO:0005847;intracellular organelle#GO:0043229 protein phosphatase#PC00195 HUMAN|HGNC=8057|UniProtKB=Q9UHK0 Q9UHK0 NUFIP1 PTHR13309:SF1 NUCLEAR FRAGILE X MENTAL RETARDATION PROTEIN INTERACTING PROTEIN 1 FMR1-INTERACTING PROTEIN NUFIP1 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;protein-RNA complex organization#GO:0071826;protein-RNA complex assembly#GO:0022618;ribonucleoprotein complex biogenesis#GO:0022613;cellular component assembly#GO:0022607;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 RNA metabolism protein#PC00031 HUMAN|HGNC=52413|UniProtKB=A0A1W2PPD8 A0A1W2PPD8 KDM4F PTHR10694:SF90 LYSINE-SPECIFIC DEMETHYLASE LYSINE-SPECIFIC DEMETHYLASE 4F-RELATED protein demethylase activity#GO:0140457;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;oxidoreductase activity#GO:0016491;demethylase activity#GO:0032451;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;histone demethylase activity#GO:0032452;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;dioxygenase activity#GO:0051213;histone modifying activity#GO:0140993 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;chromatin remodeling#GO:0006338;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;cellular process#GO:0009987;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;cellular component organization#GO:0016043;regulation of metabolic process#GO:0019222 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;nucleus#GO:0005634;chromatin#GO:0000785;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 histone modifying enzyme#PC00261 HUMAN|HGNC=1834|UniProtKB=P17676 P17676 CEBPB PTHR23334:SF21 CCAAT/ENHANCER BINDING PROTEIN CCAAT_ENHANCER-BINDING PROTEIN BETA cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of developmental process#GO:0050793;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of cell differentiation#GO:0045595;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;basic leucine zipper transcription factor#PC00056 HUMAN|HGNC=25133|UniProtKB=Q96GW9 Q96GW9 MARS2 PTHR43326:SF8 METHIONYL-TRNA SYNTHETASE METHIONINE--TRNA LIGASE, MITOCHONDRIAL catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;ligase activity#GO:0016874 nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;gene expression#GO:0010467;tRNA aminoacylation for protein translation#GO:0006418;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;tRNA aminoacylation#GO:0043039;macromolecule metabolic process#GO:0043170;amino acid activation#GO:0043038;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;protein biosynthetic process#GO:0160307;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA metabolic process#GO:0016070;protein metabolic process#GO:0019538;translation#GO:0006412 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 aminoacyl-tRNA synthetase#PC00047 HUMAN|HGNC=20311|UniProtKB=Q96JM3 Q96JM3 CHAMP1 PTHR37354:SF1 CHROMOSOME ALIGNMENT-MAINTAINING PHOSPHOPROTEIN 1 CHROMOSOME ALIGNMENT-MAINTAINING PHOSPHOPROTEIN 1 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 chromosome segregation#GO:0007059;metaphase chromosome alignment#GO:0051310;chromosome organization#GO:0051276;mitotic cell cycle process#GO:1903047;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;attachment of spindle microtubules to kinetochore#GO:0008608;organelle organization#GO:0006996;mitotic sister chromatid segregation#GO:0000070;chromosome localization#GO:0050000;attachment of mitotic spindle microtubules to kinetochore#GO:0051315;nuclear division#GO:0000280;organelle localization#GO:0051640;sister chromatid biorientation#GO:0031134;organelle fission#GO:0048285;localization#GO:0051179;cell cycle process#GO:0022402;mitotic nuclear division#GO:0140014;mitotic metaphase chromosome alignment#GO:0007080;cellular component organization#GO:0016043;sister chromatid segregation#GO:0000819;nuclear chromosome segregation#GO:0098813;cell cycle#GO:0007049;mitotic cell cycle#GO:0000278 chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;kinetochore#GO:0000776;chromosome#GO:0005694;membraneless organelle#GO:0043228;condensed chromosome#GO:0000793;cytoskeleton#GO:0005856;chromosome, centromeric region#GO:0000775;spindle#GO:0005819;intracellular membraneless organelle#GO:0043232;supramolecular complex#GO:0099080;condensed chromosome, centromeric region#GO:0000779;microtubule cytoskeleton#GO:0015630 HUMAN|HGNC=7539|UniProtKB=Q9NR99 Q9NR99 MXRA5 PTHR45842:SF4 SYNAPTIC ADHESION-LIKE MOLECULE SALM MATRIX-REMODELING-ASSOCIATED PROTEIN 5 response to endogenous stimulus#GO:0009719;response to transforming growth factor beta#GO:0071559;response to growth factor#GO:0070848;response to stimulus#GO:0050896 immunoglobulin superfamily cell adhesion molecule#PC00125;cell adhesion molecule#PC00069 HUMAN|HGNC=10258|UniProtKB=P35398 P35398 RORA PTHR45805:SF3 NUCLEAR HORMONE RECEPTOR HR3-RELATED NUCLEAR RECEPTOR ROR-ALPHA transcription regulator activity#GO:0140110;sterol binding#GO:0032934;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;lipid binding#GO:0008289;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023;transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;molecular transducer activity#GO:0060089;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;nuclear receptor activity#GO:0004879;steroid binding#GO:0005496;sequence-specific double-stranded DNA binding#GO:1990837 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of response to external stimulus#GO:0032102;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of response to stimulus#GO:0048585;regulation of response to external stimulus#GO:0032101;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of response to stimulus#GO:0048583;regulation of response to stress#GO:0080134;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;negative regulation of inflammatory response#GO:0050728;negative regulation of defense response#GO:0031348;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of defense response#GO:0031347;regulation of inflammatory response#GO:0050727 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C4 zinc finger nuclear receptor#PC00169 HUMAN|HGNC=23150|UniProtKB=Q9UPW8 Q9UPW8 UNC13A PTHR10480:SF1 PROTEIN UNC-13 HOMOLOG PROTEIN UNC-13 HOMOLOG A SNARE binding#GO:0000149;calmodulin binding#GO:0005516;binding#GO:0005488;protein binding#GO:0005515;syntaxin binding#GO:0019905 chemical synaptic transmission#GO:0007268;signal release from synapse#GO:0099643;anterograde trans-synaptic signaling#GO:0098916;organelle localization#GO:0051640;trans-synaptic signaling#GO:0099537;signal release#GO:0023061;secretion#GO:0046903;cell communication#GO:0007154;localization#GO:0051179;vesicle localization#GO:0051648;neurotransmitter secretion#GO:0007269;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;synaptic vesicle cycle#GO:0099504;transport#GO:0006810;calcium-ion regulated exocytosis#GO:0017156;establishment of localization#GO:0051234;regulation of biological process#GO:0050789;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;export from cell#GO:0140352;signaling#GO:0023052;establishment of organelle localization#GO:0051656;secretion by cell#GO:0032940;cellular localization#GO:0051641;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;synaptic vesicle exocytosis#GO:0016079;synaptic signaling#GO:0099536;cellular component biogenesis#GO:0044085;neurotransmitter transport#GO:0006836;synaptic transmission, glutamatergic#GO:0035249;establishment of vesicle localization#GO:0051650;vesicle-mediated transport#GO:0016192;cellular component assembly#GO:0022607;exocytic process#GO:0140029;regulated exocytosis#GO:0045055;protein-containing complex organization#GO:0043933;exocytosis#GO:0006887;vesicle-mediated transport in synapse#GO:0099003;cellular component organization or biogenesis#GO:0071840 synaptic vesicle#GO:0008021;synaptic vesicle membrane#GO:0030672;vesicle#GO:0031982;distal axon#GO:0150034;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;terminal bouton#GO:0043195;neuron projection terminus#GO:0044306;axon#GO:0030424;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cell periphery#GO:0071944;membrane#GO:0016020;vesicle membrane#GO:0012506;presynaptic membrane#GO:0042734;plasma membrane#GO:0005886;endomembrane system#GO:0012505;transport vesicle membrane#GO:0030658;plasma membrane region#GO:0098590;transport vesicle#GO:0030133;axon terminus#GO:0043679;organelle membrane#GO:0031090;neuromuscular junction#GO:0031594;intracellular vesicle#GO:0097708;cell projection#GO:0042995;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;presynapse#GO:0098793;neuron projection#GO:0043005;secretory vesicle#GO:0099503;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;synaptic membrane#GO:0097060;bounding membrane of organelle#GO:0098588;cell junction#GO:0030054 HUMAN|HGNC=24241|UniProtKB=Q6P1Q0 Q6P1Q0 LETMD1 PTHR14009:SF13 LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN LETM1 DOMAIN-CONTAINING PROTEIN 1 mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 secondary carrier transporter#PC00258;transporter#PC00227 HUMAN|HGNC=20637|UniProtKB=Q9BPU6 Q9BPU6 DPYSL5 PTHR11647:SF58 HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER DIHYDROPYRIMIDINASE-RELATED PROTEIN 5 hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides#GO:0016812;catalytic activity#GO:0003824;dihydropyrimidinase activity#GO:0004157 metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;nucleobase metabolic process#GO:0009112;pyrimidine nucleobase metabolic process#GO:0006206;pyrimidine-containing compound metabolic process#GO:0072527;cellular process#GO:0009987;pyrimidine nucleobase catabolic process#GO:0006208;primary metabolic process#GO:0044238;nucleobase catabolic process#GO:0046113;nucleobase-containing compound metabolic process#GO:0006139;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 hydrolase#PC00121 Axon guidance mediated by semaphorins#P00007>CRAM#P00330;Pyrimidine Metabolism#P02771>Dihydropyrimidinase#P03125 HUMAN|HGNC=13731|UniProtKB=Q7L5Y9 Q7L5Y9 MAEA PTHR12170:SF2 MACROPHAGE ERYTHROBLAST ATTACHER-RELATED E3 UBIQUITIN-PROTEIN TRANSFERASE MAEA aminoacyltransferase activity#GO:0016755;ubiquitin-protein transferase activity#GO:0004842;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740 ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;ubiquitin ligase complex#GO:0000151;intracellular organelle#GO:0043229;transferase complex#GO:1990234;catalytic complex#GO:1902494 HUMAN|HGNC=24992|UniProtKB=Q9Y5V0 Q9Y5V0 ZNF706 PTHR21213:SF34 GEO09665P1-RELATED TRANSCRIPTIONAL REGULATOR ZNF706 HUMAN|HGNC=21586|UniProtKB=Q8NG68 Q8NG68 TTL PTHR46570:SF1 TUBULIN--TYROSINE LIGASE TUBULIN--TYROSINE LIGASE catalytic activity, acting on a protein#GO:0140096;ligase activity, forming carbon-nitrogen bonds#GO:0016879;catalytic activity#GO:0003824;ligase activity#GO:0016874 cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226;cytoskeleton organization#GO:0007010;microtubule-based process#GO:0007017;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987 intracellular membraneless organelle#GO:0043232;supramolecular complex#GO:0099080;organelle#GO:0043226;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;microtubule cytoskeleton#GO:0015630;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;spindle microtubule#GO:0005876;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;spindle#GO:0005819;cytoskeleton#GO:0005856 HUMAN|HGNC=31959|UniProtKB=Q9UEU5 Q9UEU5 GAGE2D PTHR14047:SF30 P ANTIGEN FAMILY MEMBER 5-RELATED G ANTIGEN 1-RELATED HUMAN|HGNC=14977|UniProtKB=Q9Y5W7 Q9Y5W7 SNX14 PTHR22775:SF44 SORTING NEXIN SORTING NEXIN-14 small molecule binding#GO:0036094;anion binding#GO:0043168;binding#GO:0005488;phosphatidylinositol binding#GO:0035091;ion binding#GO:0043167 autophagy#GO:0006914;cellular process#GO:0009987;cellular component organization#GO:0016043;protein-containing complex disassembly#GO:0032984;macroautophagy#GO:0016236;catabolic process#GO:0009056;metabolic process#GO:0008152;autophagosome maturation#GO:0097352;process utilizing autophagic mechanism#GO:0061919;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;cellular component disassembly#GO:0022411 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;late endosome#GO:0005770;organelle#GO:0043226;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;intracellular organelle#GO:0043229 scaffold/adaptor protein#PC00226 HUMAN|HGNC=26330|UniProtKB=Q8N7U6 Q8N7U6 EFHB PTHR12086:SF12 EF-HAND DOMAIN C-TERMINAL CONTAINING PROTEIN EF-HAND DOMAIN-CONTAINING FAMILY MEMBER B molecular sensor activity#GO:0140299;molecular function regulator activity#GO:0098772 regulation of monoatomic ion transport#GO:0043269;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of calcium ion transport#GO:0051924;regulation of calcineurin-NFAT signaling cascade#GO:0070884;cilium movement involved in cell motility#GO:0060294;cellular process#GO:0009987;microtubule-based process#GO:0007017;regulation of localization#GO:0032879;regulation of transport#GO:0051049;flagellated sperm motility#GO:0030317;regulation of response to stimulus#GO:0048583;regulation of cellular process#GO:0050794;microtubule-based movement#GO:0007018;cell motility#GO:0048870;regulation of metal ion transport#GO:0010959;regulation of cell communication#GO:0010646;reproductive process#GO:0022414;regulation of calcium-mediated signaling#GO:0050848;sperm motility#GO:0097722;regulation of biological process#GO:0050789;cilium-dependent cell motility#GO:0060285;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;supramolecular fiber#GO:0099512;axoneme#GO:0005930;microtubule#GO:0005874;cilium#GO:0005929;intracellular organelle#GO:0043229;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;axonemal microtubule#GO:0005879;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasmic microtubule#GO:0005881;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ciliary plasm#GO:0097014;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;microtubule cytoskeleton#GO:0015630 calcium-binding protein#PC00060;calmodulin-related#PC00061 HUMAN|HGNC=18737|UniProtKB=Q9H8N7 Q9H8N7 ZNF395 PTHR13006:SF6 PAPILLOMAVIRUS REGULATORY FACTOR PRF-1 ZINC FINGER PROTEIN 395 RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 transcription cofactor#PC00217 HUMAN|HGNC=16732|UniProtKB=Q96PE7 Q96PE7 MCEE PTHR43048:SF3 METHYLMALONYL-COA EPIMERASE METHYLMALONYL-COA EPIMERASE, MITOCHONDRIAL isomerase activity#GO:0016853;catalytic activity#GO:0003824;racemase and epimerase activity#GO:0016854 metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;acyl-CoA metabolic process#GO:0006637;organophosphate metabolic process#GO:0019637;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;sulfur compound metabolic process#GO:0006790;purine-containing compound metabolic process#GO:0072521;cellular process#GO:0009987;small molecule metabolic process#GO:0044281;nucleobase-containing compound metabolic process#GO:0006139;nucleoside phosphate metabolic process#GO:0006753 isomerase#PC00135;epimerase/racemase#PC00096 Methylmalonyl pathway#P02755>Methylmalonyl-CoA epimerase#P03032 HUMAN|HGNC=5056|UniProtKB=P31314 P31314 TLX1 PTHR45921:SF2 IP01054P T-CELL LEUKEMIA HOMEOBOX PROTEIN 1 transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;animal gross anatomical part developmental process#GO:0160108;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;animal organ development#GO:0048513;developmental process#GO:0032502;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=23656|UniProtKB=Q3ZCQ8 Q3ZCQ8 TIMM50 PTHR12210:SF3 DULLARD PROTEIN PHOSPHATASE MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM50 catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721 mitochondrial protein import pathway#GO:7770058;protein import into mitochondrial matrix#GO:0030150;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;macromolecule localization#GO:0033036;intracellular protein localization#GO:0008104;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;intracellular protein transmembrane transport#GO:0065002;protein transmembrane import into intracellular organelle#GO:0044743;protein transmembrane transport#GO:0071806;transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;mitochondrial transport#GO:0006839;protein localization to organelle#GO:0033365;protein localization to mitochondrion#GO:0070585;protein transport#GO:0015031;localization#GO:0051179;transmembrane transport#GO:0055085;cellular localization#GO:0051641;mitochondrial transmembrane transport#GO:1990542 membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;TIM23 mitochondrial import inner membrane translocase complex#GO:0005744;mitochondrial membrane#GO:0031966;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;inner mitochondrial membrane protein complex#GO:0098800;organelle membrane#GO:0031090;organelle envelope#GO:0031967;membrane protein complex#GO:0098796;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 protein phosphatase#PC00195 HUMAN|HGNC=14598|UniProtKB=Q96T52 Q96T52 IMMP2L PTHR46041:SF2 MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2 MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2 catalytic activity#GO:0003824;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096 localization#GO:0051179;protein localization to organelle#GO:0033365;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;protein localization to mitochondrion#GO:0070585 mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrial membrane#GO:0031966;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;cytoplasm#GO:0005737;peptidase complex#GO:1905368;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;inner mitochondrial membrane protein complex#GO:0098800;endopeptidase complex#GO:1905369;organelle membrane#GO:0031090;mitochondrion#GO:0005739;organelle envelope#GO:0031967;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 protease#PC00190 HUMAN|HGNC=8962|UniProtKB=Q07326 Q07326 PIGF PTHR43157:SF79 PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED GPI ETHANOLAMINE PHOSPHATE TRANSFERASE, STABILIZING SUBUNIT lipid metabolic process#GO:0006629;GPI anchor metabolic process#GO:0006505;glycerophospholipid biosynthetic process#GO:0046474;metabolic process#GO:0008152;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;organophosphate metabolic process#GO:0019637;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604;lipid biosynthetic process#GO:0008610;glycerophospholipid metabolic process#GO:0006650;GPI anchor biosynthetic process#GO:0006506;organophosphate biosynthetic process#GO:0090407;protein metabolic process#GO:0019538;glycolipid biosynthetic process#GO:0009247;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phospholipid metabolic process#GO:0006644;phospholipid biosynthetic process#GO:0008654;glycolipid metabolic process#GO:0006664;GPI anchored protein biosynthesis#GO:0180046;glycerolipid metabolic process#GO:0046486;liposaccharide metabolic process#GO:1903509 organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;membrane#GO:0016020 glycosyltransferase#PC00111;transferase#PC00220 HUMAN|HGNC=4201|UniProtKB=Q92830 Q92830 KAT2A PTHR45750:SF1 GH11602P HISTONE ACETYLTRANSFERASE KAT2A protein N-acyltransferase activity#GO:0140186;histone acetyltransferase activity#GO:0004402;histone modifying activity#GO:0140993;acetyltransferase activity#GO:0016407;protein-lysine-acetyltransferase activity#GO:0061733;acyltransferase activity#GO:0016746;N-acetyltransferase activity#GO:0008080;protein N-acetyltransferase activity#GO:0034212;catalytic activity, acting on a protein#GO:0140096;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;catalytic activity#GO:0003824 positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;chromatin organization#GO:0006325;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of gene expression#GO:0010468;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;chromatin remodeling#GO:0006338;positive regulation of RNA metabolic process#GO:0051254;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of DNA-templated transcription#GO:0006355 chromatin#GO:0000785;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;histone acetyltransferase complex#GO:0000123;membraneless organelle#GO:0043228;chromosome#GO:0005694;cellular anatomical structure#GO:0110165;organelle#GO:0043226;protein acetyltransferase complex#GO:0031248;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;acetyltransferase complex#GO:1902493;SAGA-type complex#GO:0070461 HUMAN|HGNC=26548|UniProtKB=A2RTY3 A2RTY3 HEATR9 PTHR38323:SF1 PROTEIN HEATR9 PROTEIN HEATR9 HUMAN|HGNC=6782|UniProtKB=O60675 O60675 MAFK PTHR10129:SF26 TRANSCRIPTION FACTOR MAF TRANSCRIPTION FACTOR MAFK sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;basic leucine zipper transcription factor#PC00056 HUMAN|HGNC=5218|UniProtKB=P26439 P26439 HSD3B2 PTHR10366:SF784 NAD DEPENDENT EPIMERASE/DEHYDRATASE 3 BETA-HYDROXYSTEROID DEHYDROGENASE_DELTA 5--4-ISOMERASE TYPE 2 oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 steroid metabolic process#GO:0008202;biosynthetic process#GO:0009058;biological regulation#GO:0065007;lipid biosynthetic process#GO:0008610;hormone metabolic process#GO:0042445;cellular process#GO:0009987;regulation of hormone levels#GO:0010817;primary metabolic process#GO:0044238;regulation of biological quality#GO:0065008;steroid biosynthetic process#GO:0006694;lipid metabolic process#GO:0006629;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229 lyase#PC00144;dehydratase#PC00091;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=2204|UniProtKB=Q01955 Q01955 COL4A3 PTHR24023:SF1070 COLLAGEN ALPHA COLLAGEN ALPHA-3(IV) CHAIN structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;extracellular structure organization#GO:0043062;cellular component organization#GO:0016043 external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 Integrin signalling pathway#P00034>Collagen#P00922 HUMAN|HGNC=29109|UniProtKB=A2RU30 A2RU30 TESPA1 PTHR17469:SF1 SPERM SPECIFIC ANTIGEN 2-RELATED PROTEIN TESPA1 positive regulation of signaling#GO:0023056;regulation of immune response#GO:0050776;regulation of signaling#GO:0023051;positive regulation of cell communication#GO:0010647;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;positive regulation of signal transduction#GO:0009967;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;protein-containing complex assembly#GO:0065003;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;cellular component assembly#GO:0022607;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;cellular component biogenesis#GO:0044085;positive regulation of immune system process#GO:0002684;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=32237|UniProtKB=A6NH21 A6NH21 SERINC4 PTHR10383:SF5 SERINE INCORPORATOR SERINE INCORPORATOR 4 membrane#GO:0016020;cellular anatomical structure#GO:0110165 protein-binding activity modulator#PC00095 HUMAN|HGNC=13548|UniProtKB=Q9GZP7 Q9GZP7 VN1R1 PTHR24062:SF199 VOMERONASAL TYPE-1 RECEPTOR VOMERONASAL TYPE-1 RECEPTOR 1 binding#GO:0005488 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=9344|UniProtKB=P42785 P42785 PRCP PTHR11010:SF127 PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED LYSOSOMAL PRO-X CARBOXYPEPTIDASE blood vessel morphogenesis#GO:0048514;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;tube morphogenesis#GO:0035239;blood vessel development#GO:0001568;response to stimulus#GO:0050896;circulatory system development#GO:0072359;regulation of cellular process#GO:0050794;animal gross anatomical part developmental process#GO:0160108;regulation of cell motility#GO:2000145;anatomical structure development#GO:0048856;angiogenesis#GO:0001525;system development#GO:0048731;wound healing#GO:0042060;response to wounding#GO:0009611;response to stress#GO:0006950;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;tube development#GO:0035295;regulation of cell migration#GO:0030334;developmental process#GO:0032502;multicellular organism development#GO:0007275;vasculature development#GO:0001944;anatomical structure formation involved in morphogenesis#GO:0048646 lysosome#GO:0005764;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;vacuole#GO:0005773;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;lytic vacuole#GO:0000323 serine protease#PC00203 HUMAN|HGNC=13995|UniProtKB=Q9NQV6 Q9NQV6 PRDM10 PTHR24403:SF48 ZINC FINGER PROTEIN PR DOMAIN ZINC FINGER PROTEIN 10 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488 positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of RNA metabolic process#GO:0051254 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;transcription repressor complex#GO:0017053;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=30842|UniProtKB=Q7Z3Y7 Q7Z3Y7 KRT28 PTHR23239:SF215 INTERMEDIATE FILAMENT KERATIN, TYPE I CYTOSKELETAL 28 structural molecule activity#GO:0005198 anatomical structure development#GO:0048856;tissue morphogenesis#GO:0048729;supramolecular fiber organization#GO:0097435;animal gross anatomical part developmental process#GO:0160108;intermediate filament-based process#GO:0045103;intermediate filament organization#GO:0045109;intermediate filament cytoskeleton organization#GO:0045104;cell differentiation#GO:0030154;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cellular developmental process#GO:0048869;animal organ development#GO:0048513;cellular component organization or biogenesis#GO:0071840;morphogenesis of an epithelium#GO:0002009;epidermis development#GO:0008544;developmental process#GO:0032502;multicellular organismal process#GO:0032501;tissue development#GO:0009888;epithelial cell differentiation#GO:0030855;epithelium development#GO:0060429;skin development#GO:0043588;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular process#GO:0009987 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;intermediate filament#GO:0005882;supramolecular fiber#GO:0099512;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;organelle#GO:0043226;supramolecular complex#GO:0099080 intermediate filament#PC00129 HUMAN|HGNC=30395|UniProtKB=Q9BVL4 Q9BVL4 SELENOO PTHR12153:SF15 SELENOPROTEIN O PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL HUMAN|HGNC=12690|UniProtKB=P09327 P09327 VIL1 PTHR11977:SF35 VILLIN VILLIN-1 phosphatidylinositol phosphate binding#GO:1901981;cytoskeletal protein binding#GO:0008092;phospholipid binding#GO:0005543;lipid binding#GO:0008289;protein-containing complex binding#GO:0044877;phosphatidylinositol bisphosphate binding#GO:1902936;protein binding#GO:0005515;actin binding#GO:0003779;actin filament binding#GO:0051015;phosphatidylinositol-4,5-bisphosphate binding#GO:0005546;ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;binding#GO:0005488 negative regulation of actin filament depolymerization#GO:0030835;regulation of biological quality#GO:0065008;regulation of actin filament length#GO:0030832;regulation of cellular component organization#GO:0051128;negative regulation of actin filament polymerization#GO:0030837;regulation of cellular component biogenesis#GO:0044087;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;regulation of protein-containing complex assembly#GO:0043254;regulation of cellular component size#GO:0032535;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;cellular component organization or biogenesis#GO:0071840;regulation of anatomical structure morphogenesis#GO:0022603;regulation of anatomical structure size#GO:0090066;cytoskeleton organization#GO:0007010;regulation of actin cytoskeleton organization#GO:0032956;organelle organization#GO:0006996;regulation of protein-containing complex disassembly#GO:0043244;cellular process#GO:0009987;negative regulation of cytoskeleton organization#GO:0051494;negative regulation of protein-containing complex disassembly#GO:0043242;negative regulation of protein-containing complex assembly#GO:0031333;supramolecular fiber organization#GO:0097435;negative regulation of protein polymerization#GO:0032272;actin filament capping#GO:0051693;actin filament-based process#GO:0030029;negative regulation of supramolecular fiber organization#GO:1902904;regulation of protein polymerization#GO:0032271;regulation of cytoskeleton organization#GO:0051493;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;regulation of developmental process#GO:0050793;regulation of actin filament depolymerization#GO:0030834;negative regulation of cellular component organization#GO:0051129;negative regulation of organelle organization#GO:0010639;regulation of supramolecular fiber organization#GO:1902903;regulation of plasma membrane bounded cell projection organization#GO:0120035;actin filament organization#GO:0007015;regulation of protein depolymerization#GO:1901879;regulation of cell projection organization#GO:0031344;negative regulation of cellular process#GO:0048523;regulation of actin filament-based process#GO:0032970;regulation of actin filament polymerization#GO:0030833;regulation of actin polymerization or depolymerization#GO:0008064;biological regulation#GO:0065007;negative regulation of protein depolymerization#GO:1901880;regulation of actin filament organization#GO:0110053;actin polymerization or depolymerization#GO:0008154 lamellipodium#GO:0030027;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;actin cytoskeleton#GO:0015629;cell leading edge#GO:0031252;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 actin or actin-binding cytoskeletal protein#PC00041;non-motor actin binding protein#PC00165 HUMAN|HGNC=2433|UniProtKB=P07333 P07333 CSF1R PTHR24416:SF47 TYROSINE-PROTEIN KINASE RECEPTOR MACROPHAGE COLONY-STIMULATING FACTOR 1 RECEPTOR transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488;protein kinase activity#GO:0004672;growth factor binding#GO:0019838;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein binding#GO:0005515;kinase activity#GO:0016301;transferase activity#GO:0016740;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity, acting on a protein#GO:0140096 positive regulation of cell migration#GO:0030335;positive regulation of cellular process#GO:0048522;regulation of locomotion#GO:0040012;hemopoiesis#GO:0030097;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;cell migration#GO:0016477;regulation of response to stimulus#GO:0048583;developmental process#GO:0032502;regulation of cell migration#GO:0030334;positive regulation of locomotion#GO:0040017;cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;regulation of cell communication#GO:0010646;cell motility#GO:0048870;regulation of cellular process#GO:0050794;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;osteoclast differentiation#GO:0030316;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;regulation of cell motility#GO:2000145;regulation of cell population proliferation#GO:0042127;cell communication#GO:0007154;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cell surface receptor signaling pathway#GO:0007166;regulation of MAPK cascade#GO:0043408;regulation of biological process#GO:0050789;leukocyte differentiation#GO:0002521;positive regulation of cell motility#GO:2000147;positive regulation of cell population proliferation#GO:0008284;cell development#GO:0048468;signaling#GO:0023052;myeloid cell differentiation#GO:0030099;response to stimulus#GO:0050896;cell differentiation#GO:0030154;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;signaling receptor complex#GO:0043235;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=37331|UniProtKB=Q8TDU5 Q8TDU5 VN1R17P PTHR24062:SF207 VOMERONASAL TYPE-1 RECEPTOR VOMERONASAL RECEPTOR-LIKE PROTEIN 4-RELATED binding#GO:0005488 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=23700|UniProtKB=Q9H892 Q9H892 TTC12 PTHR46540:SF1 TETRATRICOPEPTIDE REPEAT PROTEIN 12 TETRATRICOPEPTIDE REPEAT PROTEIN 12 developmental process involved in reproduction#GO:0003006;germ cell development#GO:0007281;cell motility#GO:0048870;microtubule-based movement#GO:0007018;reproductive process#GO:0022414;organelle assembly#GO:0070925;sexual reproduction#GO:0019953;spermatid development#GO:0007286;axonemal dynein complex assembly#GO:0070286;microtubule bundle formation#GO:0001578;microtubule cytoskeleton organization#GO:0000226;anatomical structure development#GO:0048856;axoneme assembly#GO:0035082;multicellular organismal reproductive process#GO:0048609;male gamete generation#GO:0048232;plasma membrane bounded cell projection organization#GO:0120036;plasma membrane bounded cell projection assembly#GO:0120031;flagellated sperm motility#GO:0030317;developmental process#GO:0032502;spermatogenesis#GO:0007283;cellular developmental process#GO:0048869;sperm axoneme assembly#GO:0007288;cilium assembly#GO:0060271;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;sperm motility#GO:0097722;cell differentiation#GO:0030154;cell projection organization#GO:0030030;gamete generation#GO:0007276;cell development#GO:0048468;cellular process involved in reproduction in multicellular organism#GO:0022412;spermatid differentiation#GO:0048515;cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;sperm flagellum assembly#GO:0120316;cilium-dependent cell motility#GO:0060285;cilium organization#GO:0044782;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cilium movement involved in cell motility#GO:0060294;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;motile cilium assembly#GO:0044458;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;protein-containing complex organization#GO:0043933 microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;centrosome#GO:0005813;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 HUMAN|HGNC=6909|UniProtKB=O15232 O15232 MATN3 PTHR24020:SF12 COLLAGEN ALPHA MATRILIN-3 extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical structure#GO:0110165 extracellular matrix structural protein#PC00103 HUMAN|HGNC=6908|UniProtKB=O00339 O00339 MATN2 PTHR24020:SF35 COLLAGEN ALPHA MATRILIN-2 extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cellular anatomical structure#GO:0110165 extracellular matrix structural protein#PC00103 HUMAN|HGNC=29858|UniProtKB=Q9UBE8 Q9UBE8 NLK PTHR24055:SF380 MITOGEN-ACTIVATED PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE NLK phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634 non-receptor serine/threonine protein kinase#PC00167 Wnt signaling pathway#P00057>Nemo-like Kinase#P01449 HUMAN|HGNC=24888|UniProtKB=Q7Z6Z6 Q7Z6Z6 PNPLA5 PTHR12406:SF4 CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 IPLA2 -RELATED PATATIN-LIKE PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN 5 hydrolase activity, acting on ester bonds#GO:0016788;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;carboxylic ester hydrolase activity#GO:0052689;triacylglycerol lipase activity#GO:0004806;acyltransferase activity#GO:0016746;lipase activity#GO:0016298;hydrolase activity#GO:0016787 acylglycerol catabolic process#GO:0046464;neutral lipid metabolic process#GO:0006638;neutral lipid catabolic process#GO:0046461;triglyceride metabolic process#GO:0006641;chemical homeostasis#GO:0048878;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;acylglycerol metabolic process#GO:0006639;lipid catabolic process#GO:0016042;cellular process#GO:0009987;triglyceride catabolic process#GO:0019433;glycerolipid catabolic process#GO:0046503;homeostatic process#GO:0042592;glycerolipid metabolic process#GO:0046486;catabolic process#GO:0009056;primary metabolic process#GO:0044238;lipid homeostasis#GO:0055088 intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;membraneless organelle#GO:0043228;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membraneless organelle#GO:0043232;lipid droplet#GO:0005811 phospholipase#PC00186 HUMAN|HGNC=20440|UniProtKB=Q5VWZ2 Q5VWZ2 LYPLAL1 PTHR10655:SF74 LYSOPHOSPHOLIPASE-RELATED LYSOPHOSPHOLIPASE-LIKE PROTEIN 1 catalytic activity, acting on a protein#GO:0140096;palmitoyl hydrolase activity#GO:0098599;hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788;thiolester hydrolase activity#GO:0016790;catalytic activity#GO:0003824 negative regulation of cellular process#GO:0048523;regulation of establishment of protein localization#GO:0070201;regulation of protein localization#GO:0032880;regulation of localization#GO:0032879;regulation of transport#GO:0051049;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;regulation of protein localization to membrane#GO:1905475;negative regulation of biological process#GO:0048519;biological regulation#GO:0065007;negative regulation of protein transport#GO:0051224;negative regulation of transport#GO:0051051;regulation of protein transport#GO:0051223;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 lipase#PC00143;phospholipase#PC00186 HUMAN|HGNC=9025|UniProtKB=Q9Y446 Q9Y446 PKP3 PTHR10372:SF1 PLAKOPHILLIN-RELATED PLAKOPHILIN-3 cell adhesion molecule binding#GO:0050839;binding#GO:0005488;protein binding#GO:0005515 cell-cell adhesion#GO:0098609;cellular process#GO:0009987;cell adhesion#GO:0007155 nucleus#GO:0005634;cell periphery#GO:0071944;cell-cell junction#GO:0005911;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;adherens junction#GO:0005912;membrane-bounded organelle#GO:0043227;anchoring junction#GO:0070161;intracellular anatomical structure#GO:0005622;cell junction#GO:0030054 intermediate filament#PC00129;cytoskeletal protein#PC00085;intermediate filament binding protein#PC00130 HUMAN|HGNC=30533|UniProtKB=A0A1B0GTR3 A0A1B0GTR3 CXorf51A PTHR37876:SF1 PROTEIN GAR2-LIKE SPERMATID NUCLEAR TRANSITION PROTEIN 4 HUMAN|HGNC=9775|UniProtKB=O95755 O95755 RAB36 PTHR47977:SF10 RAS-RELATED PROTEIN RAB RAS-RELATED PROTEIN RAB-36 GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;nucleoside phosphate binding#GO:1901265;guanyl nucleotide binding#GO:0019001;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;small molecule binding#GO:0036094;anion binding#GO:0043168;GTPase activity#GO:0003924;ion binding#GO:0043167;ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleotide binding#GO:0000166;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462 localization#GO:0051179;establishment of localization#GO:0051234;vesicle-mediated transport#GO:0016192;transport#GO:0006810;cellular process#GO:0009987 small GTPase#PC00208 HUMAN|HGNC=9091|UniProtKB=P13797 P13797 PLS3 PTHR19961:SF32 FIMBRIN/PLASTIN PLASTIN-3 protein-containing complex binding#GO:0044877;protein binding#GO:0005515;actin binding#GO:0003779;actin filament binding#GO:0051015;protein-macromolecule adaptor activity#GO:0030674;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;molecular adaptor activity#GO:0060090 cellular component organization or biogenesis#GO:0071840;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;actin filament-based process#GO:0030029;actin cytoskeleton organization#GO:0030036;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;actin filament bundle organization#GO:0061572;actin filament bundle assembly#GO:0051017 actin cytoskeleton#GO:0015629;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;actin filament bundle#GO:0032432;cell periphery#GO:0071944;membrane#GO:0016020;cytoplasm#GO:0005737;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;actin filament#GO:0005884;cytoskeleton#GO:0005856;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228 non-motor actin binding protein#PC00165;actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=7372|UniProtKB=P08118 P08118 MSMB PTHR10500:SF8 BETA-MICROSEMINOPROTEIN BETA-MICROSEMINOPROTEIN intercellular signal molecule#PC00207 HUMAN|HGNC=16346|UniProtKB=Q8NHK3 Q8NHK3 KIR2DL5B PTHR11738:SF113 MHC CLASS I NK CELL RECEPTOR KILLER CELL IMMUNOGLOBULIN-LIKE RECEPTOR 2DL5A-RELATED transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;immune receptor activity#GO:0140375 cell communication#GO:0007154;regulation of immune response#GO:0050776;regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;biological regulation#GO:0065007;signaling#GO:0023052;immune response-regulating cell surface receptor signaling pathway#GO:0002768;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;immune response-regulating signaling pathway#GO:0002764;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=30309|UniProtKB=O15258 O15258 RER1 PTHR10743:SF0 PROTEIN RER1 PROTEIN RER1 protein localization to organelle#GO:0033365;vesicle-mediated transport#GO:0016192;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;cellular process#GO:0009987;macromolecule localization#GO:0033036;intracellular protein localization#GO:0008104;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;transport#GO:0006810;Golgi vesicle transport#GO:0048193 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;membrane#GO:0016020;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139 HUMAN|HGNC=21792|UniProtKB=Q8ND71 Q8ND71 GIMAP8 PTHR10903:SF73 GTPASE, IMAP FAMILY MEMBER-RELATED GTPASE IMAP FAMILY MEMBER 8 hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 small GTPase#PC00208 HUMAN|HGNC=10862|UniProtKB=Q11201 Q11201 ST3GAL1 PTHR46032:SF6 ALPHA-2,3-SIALYLTRANSFERASE ST3GAL I ISOFORM X1 CMP-N-ACETYLNEURAMINATE-BETA-GALACTOSAMIDE-ALPHA-2,3-SIALYLTRANSFERASE 1 glycosyltransferase activity#GO:0016757;sialyltransferase activity#GO:0008373;transferase activity#GO:0016740;catalytic activity#GO:0003824 glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;biosynthetic process#GO:0009058 cellular anatomical structure#GO:0110165;membrane#GO:0016020 transferase#PC00220 HUMAN|HGNC=35245|UniProtKB=A1L190 A1L190 SYCE3 PTHR36686:SF1 SYNAPTONEMAL COMPLEX CENTRAL ELEMENT PROTEIN 3 SYNAPTONEMAL COMPLEX CENTRAL ELEMENT PROTEIN 3 homologous recombination#GO:0035825;reproductive process#GO:0022414;cell cycle#GO:0007049;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;reciprocal homologous recombination#GO:0140527;organelle fission#GO:0048285;meiosis I cell cycle process#GO:0061982;sexual reproduction#GO:0019953;nucleobase-containing compound metabolic process#GO:0006139;macromolecule metabolic process#GO:0043170;meiotic nuclear division#GO:0140013;meiotic chromosome segregation#GO:0045132;chromosome organization#GO:0051276;meiotic cell cycle process#GO:1903046;cellular component organization#GO:0016043;meiosis I#GO:0007127;nuclear chromosome segregation#GO:0098813;cell cycle process#GO:0022402;nuclear division#GO:0000280;reciprocal meiotic recombination#GO:0007131;cellular component assembly#GO:0022607;synaptonemal complex assembly#GO:0007130;homologous chromosome pairing at meiosis#GO:0007129;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;homologous chromosome segregation#GO:0045143;chromosome organization involved in meiotic cell cycle#GO:0070192;meiotic cell cycle#GO:0051321;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;DNA recombination#GO:0006310;chromosome segregation#GO:0007059 synaptonemal complex#GO:0000795;condensed nuclear chromosome#GO:0000794;membraneless organelle#GO:0043228;condensed chromosome#GO:0000793;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;synaptonemal structure#GO:0099086;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;central element#GO:0000801;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;organelle lumen#GO:0043233 HUMAN|HGNC=26912|UniProtKB=Q8NBT3 Q8NBT3 TMEM145 PTHR23252:SF24 INTIMAL THICKNESS RECEPTOR-RELATED TRANSMEMBRANE PROTEIN 145 HUMAN|HGNC=27273|UniProtKB=Q6PEW1 Q6PEW1 ZCCHC12 PTHR23095:SF18 PARANEOPLASTIC ANTIGEN ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 12 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 transcription cofactor#PC00217 HUMAN|HGNC=449|UniProtKB=O95076 O95076 ALX3 PTHR24329:SF578 HOMEOBOX PROTEIN ARISTALESS HOMEOBOX PROTEIN ARISTALESS-LIKE 3 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=10535|UniProtKB=Q9Y6B6 Q9Y6B6 SAR1B PTHR45684:SF20 RE74312P SMALL COPII COAT GTPASE SAR1B ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824 COPII-coated vesicle budding#GO:0090114;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;localization#GO:0051179;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;Golgi vesicle transport#GO:0048193;transport#GO:0006810;intracellular transport#GO:0046907;vesicle organization#GO:0016050;protein-containing complex organization#GO:0043933;vesicle budding from membrane#GO:0006900;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;membrane organization#GO:0061024;vesicle-mediated transport#GO:0016192;cellular component assembly#GO:0022607 vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;coated vesicle membrane#GO:0030662;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;coated vesicle#GO:0030135;coated membrane#GO:0048475;membrane coat#GO:0030117;COPII-coated ER to Golgi transport vesicle#GO:0030134;vesicle membrane#GO:0012506;membrane#GO:0016020;vesicle coat#GO:0030120;cytoplasm#GO:0005737;transport vesicle#GO:0030133;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;transport vesicle membrane#GO:0030658;ER to Golgi transport vesicle membrane#GO:0012507;endoplasmic reticulum exit site#GO:0070971;endoplasmic reticulum#GO:0005783;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090 HUMAN|HGNC=26859|UniProtKB=Q8N7X1 Q8N7X1 RBMXL3 PTHR13952:SF27 U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KD RNA-BINDING MOTIF PROTEIN, X-LINKED-LIKE-3 snRNA binding#GO:0017069;RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729 macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;precatalytic spliceosome#GO:0071011;ribonucleoprotein complex#GO:1990904;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;spliceosomal complex#GO:0005681 RNA splicing factor#PC00148 HUMAN|HGNC=26670|UniProtKB=A2RUB1 A2RUB1 MEIOC PTHR33861:SF3 PROTEIN CBG18333 MEIOSIS-SPECIFIC COILED-COIL DOMAIN-CONTAINING PROTEIN MEIOC male meiotic nuclear division#GO:0007140;mRNA stabilization#GO:0048255;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization or biogenesis#GO:0071840;regulation of mRNA metabolic process#GO:1903311;negative regulation of RNA metabolic process#GO:0051253;meiotic cell cycle#GO:0051321;negative regulation of metabolic process#GO:0009892;regulation of mRNA stability#GO:0043488;gamete generation#GO:0007276;regulation of biological process#GO:0050789;cell cycle process#GO:0022402;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;meiosis I#GO:0007127;meiotic cell cycle process#GO:1903046;cellular component organization#GO:0016043;regulation of biological quality#GO:0065008;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;RNA stabilization#GO:0043489;nuclear division#GO:0000280;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;male gamete generation#GO:0048232;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;regulation of biosynthetic process#GO:0009889;meiotic nuclear division#GO:0140013;negative regulation of RNA catabolic process#GO:1902369;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;reproductive process#GO:0022414;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;cell cycle#GO:0007049;negative regulation of catabolic process#GO:0009895;multicellular organismal reproductive process#GO:0048609;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;organelle fission#GO:0048285;sexual reproduction#GO:0019953;meiosis I cell cycle process#GO:0061982;regulation of RNA stability#GO:0043487 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=9090|UniProtKB=Q14651 Q14651 PLS1 PTHR19961:SF27 FIMBRIN/PLASTIN PLASTIN-1 binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;actin filament binding#GO:0051015;actin binding#GO:0003779;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;molecular adaptor activity#GO:0060090;cytoskeletal protein binding#GO:0008092 cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;actin filament bundle organization#GO:0061572;actin filament bundle assembly#GO:0051017;actin cytoskeleton organization#GO:0030036;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;actin filament-based process#GO:0030029;cellular component organization or biogenesis#GO:0071840;actin filament organization#GO:0007015;supramolecular fiber organization#GO:0097435 supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;cytoplasm#GO:0005737;membrane#GO:0016020;cell periphery#GO:0071944;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cytoskeleton#GO:0005856;actin filament#GO:0005884;organelle#GO:0043226;cellular anatomical structure#GO:0110165;actin cytoskeleton#GO:0015629;actin filament bundle#GO:0032432;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 non-motor actin binding protein#PC00165;actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=30439|UniProtKB=Q7Z4S9 Q7Z4S9 SH2D6 PTHR14098:SF16 SH2 DOMAIN CONTAINING PROTEIN SH2 DOMAIN-CONTAINING PROTEIN 6 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cell surface receptor signaling pathway#GO:0007166;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=16663|UniProtKB=Q6MZZ7 Q6MZZ7 CAPN13 PTHR10183:SF333 CALPAIN CALPAIN-13 catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;cysteine-type endopeptidase activity#GO:0004197;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096 cellular process#GO:0009987;primary metabolic process#GO:0044238;proteolysis#GO:0006508;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protease#PC00190;cysteine protease#PC00081 HUMAN|HGNC=59|UniProtKB=Q09428 Q09428 ABCC8 PTHR24223:SF187 ATP-BINDING CASSETTE SUB-FAMILY C ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 cellular process#GO:0009987;transport#GO:0006810;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 ATP-binding cassette (ABC) transporter#PC00003 HUMAN|HGNC=12117|UniProtKB=A0A0B4J274 A0A0B4J274 TRAV20 PTHR19433:SF114 T-CELL RECEPTOR ALPHA CHAIN V REGION-RELATED T CELL RECEPTOR ALPHA VARIABLE 20-RELATED response to other organism#GO:0051707;response to external stimulus#GO:0009605;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to stimulus#GO:0050896;response to bacterium#GO:0009617;response to biotic stimulus#GO:0009607 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=5610|UniProtKB=P01767 P01767 IGHV3-53 PTHR23266:SF384 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 3-53-RELATED antigen binding#GO:0003823;binding#GO:0005488 response to stimulus#GO:0050896;adaptive immune response#GO:0002250;immune response#GO:0006955;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;immune system process#GO:0002376;immune effector process#GO:0002252 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=10468|UniProtKB=O75298 O75298 RTN2 PTHR45799:SF3 RETICULON-LIKE PROTEIN RETICULON-2 cellular process#GO:0009987;endoplasmic reticulum organization#GO:0007029;organelle organization#GO:0006996;cellular component organization#GO:0016043;membrane organization#GO:0061024;endomembrane system organization#GO:0010256;endoplasmic reticulum tubular network organization#GO:0071786;endoplasmic reticulum membrane organization#GO:0090158;cellular component organization or biogenesis#GO:0071840 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum membrane#GO:0005789 HUMAN|HGNC=5838|UniProtKB=A0A0C4DH26 A0A0C4DH26 IGKV6D-41 PTHR23267:SF482 IMMUNOGLOBULIN LIGHT CHAIN NON-FUNCTIONAL IMMUNOGLOBULIN KAPPA VARIABLE 6D-41-RELATED response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 protein-containing complex#GO:0032991 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=3300|UniProtKB=P63241 P63241 EIF5A PTHR11673:SF34 TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER EUKARYOTIC TRANSLATION INITIATION FACTOR 5A-1 translation elongation factor activity#GO:0003746;translation factor activity#GO:0180051 protein biosynthetic process#GO:0160307;gene expression#GO:0010467;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;translational elongation#GO:0006414;metabolic process#GO:0008152;translation#GO:0006412 translation factor#PC00223;translation initiation factor#PC00224;translational protein#PC00263 HUMAN|HGNC=26945|UniProtKB=Q9UDX5 Q9UDX5 MTFP1 PTHR11001:SF2 MITOCHONDRIAL FISSION PROCESS PROTEIN 1 MITOCHONDRIAL FISSION PROCESS PROTEIN 1 organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;mitochondrial fission#GO:0000266;organelle fission#GO:0048285;mitochondrion organization#GO:0007005 mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=14428|UniProtKB=Q9H2T7 Q9H2T7 RANBP17 PTHR12596:SF8 EXPORTIN 4,7-RELATED RAN-BINDING PROTEIN 17 nucleocytoplasmic carrier activity#GO:0140142;molecular carrier activity#GO:0140104 localization#GO:0051179;cellular localization#GO:0051641;nuclear transport#GO:0051169;nuclear export#GO:0051168;protein transport#GO:0015031;nucleocytoplasmic transport#GO:0006913;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810;protein export from nucleus#GO:0006611;macromolecule localization#GO:0033036;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987 nucleus#GO:0005634;organelle envelope#GO:0031967;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;nuclear pore#GO:0005643;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513 transporter#PC00227 HUMAN|HGNC=15502|UniProtKB=Q96BZ8 Q96BZ8 LENG1 PTHR22093:SF0 LEUKOCYTE RECEPTOR CLUSTER LRC MEMBER 1 LEUKOCYTE RECEPTOR CLUSTER MEMBER 1 HUMAN|HGNC=17106|UniProtKB=Q8NFU0 Q8NFU0 BEST4 PTHR10736:SF55 BESTROPHIN BESTROPHIN-4 passive transmembrane transporter activity#GO:0022803;chloride transmembrane transporter activity#GO:0015108;chloride channel activity#GO:0005254;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic anion transmembrane transporter activity#GO:0008509;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic anion channel activity#GO:0005253;channel activity#GO:0015267 monoatomic anion transport#GO:0006820;cellular process#GO:0009987;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220;chloride transport#GO:0006821;transport#GO:0006810;chloride transmembrane transport#GO:1902476;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;inorganic anion transport#GO:0015698;monoatomic ion transport#GO:0006811 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=29526|UniProtKB=Q0VDF9 Q0VDF9 HSPA14 PTHR19375:SF438 HEAT SHOCK PROTEIN 70KDA HEAT SHOCK 70 KDA PROTEIN 14 binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP-dependent activity#GO:0140657;protein binding#GO:0005515;hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;heat shock protein binding#GO:0031072;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111 metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;protein refolding#GO:0042026;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;protein folding#GO:0006457 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;ribosome#GO:0005840 chaperone#PC00072;Hsp70 family chaperone#PC00027 HUMAN|HGNC=10986|UniProtKB=P16260 P16260 SLC25A16 PTHR24089:SF705 SOLUTE CARRIER FAMILY 25 MITOCHONDRIAL COENZYME A TRANSPORTER SLC25A16 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;nucleobase-containing compound transmembrane transporter activity#GO:0015932;organophosphate ester transmembrane transporter activity#GO:0015605 organophosphate ester transport#GO:0015748;nucleobase-containing compound transport#GO:0015931;cellular process#GO:0009987;nitrogen compound transport#GO:0071705;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810 intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;organelle envelope#GO:0031967 secondary carrier transporter#PC00258;mitochondrial carrier protein#PC00158 HUMAN|HGNC=19574|UniProtKB=Q8NH01 Q8NH01 OR2T11 PTHR26453:SF173 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2T11 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception#GO:0007600;nervous system process#GO:0050877;response to stimulus#GO:0050896;response to chemical#GO:0042221;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;detection of chemical stimulus#GO:0009593 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=28286|UniProtKB=Q08AF3 Q08AF3 SLFN5 PTHR12155:SF26 SCHLAFEN SCHLAFEN FAMILY MEMBER 5 endoribonuclease#PC00094 HUMAN|HGNC=32152|UniProtKB=Q8WW27 Q8WW27 APOBEC4 PTHR35672:SF1 C-U-EDITING ENZYME APOBEC-4-RELATED DEAMINASE APOBEC-4-RELATED HUMAN|HGNC=15910|UniProtKB=Q9Y697 Q9Y697 NFS1 PTHR11601:SF65 CYSTEINE DESULFURYLASE FAMILY MEMBER CYSTEINE DESULFURASE transferase activity, transferring sulphur-containing groups#GO:0016782;sulfurtransferase activity#GO:0016783;catalytic activity#GO:0003824;transferase activity#GO:0016740 iron-sulfur cluster assembly#GO:0016226;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular process#GO:0009987;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cytosol#GO:0005829;nucleus#GO:0005634;mitochondrion#GO:0005739 lyase#PC00144;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=12862|UniProtKB=P26651 P26651 ZFP36 PTHR12547:SF58 CCCH ZINC FINGER/TIS11-RELATED MRNA DECAY ACTIVATOR PROTEIN ZFP36 molecular adaptor activity#GO:0060090;protein-RNA adaptor activity#GO:0140517;mRNA 3'-UTR binding#GO:0003730;translation regulator activity#GO:0045182;mRNA binding#GO:0003729;protein-macromolecule adaptor activity#GO:0030674;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 regulation of RNA metabolic process#GO:0051252;regulation of RNA stability#GO:0043487;catabolic process#GO:0009056;nuclear-transcribed mRNA poly(A) tail shortening#GO:0000289;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;positive regulation of mRNA catabolic process#GO:0061014;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;macromolecule metabolic process#GO:0043170;positive regulation of catabolic process#GO:0009896;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;nucleobase-containing compound catabolic process#GO:0034655;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;nucleic acid catabolic process#GO:0141188;positive regulation of metabolic process#GO:0009893;RNA metabolic process#GO:0016070;regulation of biological quality#GO:0065008;RNA catabolic process#GO:0006401;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;regulation of mRNA stability#GO:0043488;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;regulation of mRNA metabolic process#GO:1903311;metabolic process#GO:0008152;positive regulation of mRNA metabolic process#GO:1903313;macromolecule catabolic process#GO:0009057;mRNA destabilization#GO:0061157;positive regulation of macromolecule metabolic process#GO:0010604;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;RNA destabilization#GO:0050779;positive regulation of biological process#GO:0048518;cellular process#GO:0009987 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031 HUMAN|HGNC=25183|UniProtKB=Q8TC57 Q8TC57 M1AP PTHR28642:SF1 MEIOSIS 1 ARREST PROTEIN MEIOSIS 1 ARREST PROTEIN chromosome separation#GO:0051304;meiotic nuclear division#GO:0140013;cellular component organization or biogenesis#GO:0071840;meiotic chromosome segregation#GO:0045132;meiotic cell cycle#GO:0051321;spermatogenesis#GO:0007283;chromosome segregation#GO:0007059;developmental process#GO:0032502;male gamete generation#GO:0048232;male meiotic nuclear division#GO:0007140;organelle organization#GO:0006996;cellular process#GO:0009987;organelle fission#GO:0048285;multicellular organismal reproductive process#GO:0048609;nuclear division#GO:0000280;sexual reproduction#GO:0019953;gamete generation#GO:0007276;reproductive process#GO:0022414;nuclear chromosome segregation#GO:0098813;developmental process involved in reproduction#GO:0003006;meiotic cell cycle process#GO:1903046;cellular component organization#GO:0016043;cell cycle#GO:0007049;cell cycle process#GO:0022402 HUMAN|HGNC=7396|UniProtKB=A1L3X4 A1L3X4 MT1DP PTHR23299:SF24 METALLOTHIONEIN METALLOTHIONEIN-1E-RELATED defense/immunity protein#PC00090 HUMAN|HGNC=12434|UniProtKB=P42681 P42681 TXK PTHR24418:SF247 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE TXK non-membrane spanning protein tyrosine kinase activity#GO:0004715;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;catalytic activity, acting on a protein#GO:0140096 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 non-receptor tyrosine protein kinase#PC00168 HUMAN|HGNC=28419|UniProtKB=Q9BQ49 Q9BQ49 SMIM7 PTHR28622:SF1 SMALL INTEGRAL MEMBRANE PROTEIN 7 SMALL INTEGRAL MEMBRANE PROTEIN 7 HUMAN|HGNC=26386|UniProtKB=Q8N4S7 Q8N4S7 PAQR4 PTHR20855:SF138 ADIPOR/PROGESTIN RECEPTOR-RELATED PROGESTIN AND ADIPOQ RECEPTOR FAMILY MEMBER 4 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=1480|UniProtKB=P20807 P20807 CAPN3 PTHR10183:SF329 CALPAIN CALPAIN-3 cysteine-type endopeptidase activity#GO:0004197;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;proteolysis#GO:0006508;metabolic process#GO:0008152;negative regulation of cellular process#GO:0048523;regulation of apoptotic process#GO:0042981;negative regulation of apoptotic process#GO:0043066;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;primary metabolic process#GO:0044238;negative regulation of programmed cell death#GO:0043069;regulation of biological process#GO:0050789;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 cysteine protease#PC00081;protease#PC00190 Huntington disease#P00029>Calpain#P00788 HUMAN|HGNC=6983|UniProtKB=P48163 P48163 ME1 PTHR23406:SF17 MALIC ENZYME-RELATED NADP-DEPENDENT MALIC ENZYME oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739 oxidoreductase#PC00176 Pyruvate metabolism#P02772>Malic enzyme#P03136 HUMAN|HGNC=14026|UniProtKB=Q96PZ7 Q96PZ7 CSMD1 PTHR45656:SF3 PROTEIN CBR-CLEC-78 CUB AND SUSHI DOMAIN-CONTAINING PROTEIN 1 morphogenesis of a branching structure#GO:0001763;tube development#GO:0035295;tissue development#GO:0009888;multicellular organismal process#GO:0032501;epithelium development#GO:0060429;developmental process#GO:0032502;morphogenesis of an epithelium#GO:0002009;animal organ development#GO:0048513;multicellular organism development#GO:0007275;multi-multicellular organism process#GO:0044706;tube morphogenesis#GO:0035239;anatomical structure morphogenesis#GO:0009653;developmental process involved in reproduction#GO:0003006;reproductive process#GO:0022414;animal organ morphogenesis#GO:0009887;animal gross anatomical part developmental process#GO:0160108;multicellular organismal reproductive process#GO:0048609;anatomical structure development#GO:0048856;tissue morphogenesis#GO:0048729 HUMAN|HGNC=12546|UniProtKB=P54855 P54855 UGT2B15 PTHR48043:SF64 EG:EG0003.4 PROTEIN-RELATED UDP-GLUCURONOSYLTRANSFERASE 2B15 UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;transferase activity#GO:0016740;catalytic activity#GO:0003824;glucuronosyltransferase activity#GO:0015020;hexosyltransferase activity#GO:0016758 HUMAN|HGNC=26791|UniProtKB=Q5VTJ3 Q5VTJ3 KLHDC7A PTHR45972:SF1 BTB_2 DOMAIN-CONTAINING PROTEIN KELCH DOMAIN-CONTAINING PROTEIN 7A HUMAN|HGNC=34439|UniProtKB=A8MZ97 A8MZ97 C2orf74 PTHR37882:SF1 HYPOTHETICAL PROTEIN LOC690352 SIMILAR TO HUMAN CHROMOSOME 2 OPEN READING FRAME 74 HUMAN|HGNC=9894|UniProtKB=Q08999 Q08999 RBL2 PTHR13742:SF8 RETINOBLASTOMA-ASSOCIATED PROTEIN RB -RELATED RETINOBLASTOMA-LIKE PROTEIN 2 double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of cell cycle#GO:0051726;regulation of cell cycle G1/S phase transition#GO:1902806;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of biological process#GO:0050789;negative regulation of cell cycle phase transition#GO:1901988;regulation of cell cycle phase transition#GO:1901987;negative regulation of biological process#GO:0048519;negative regulation of mitotic cell cycle#GO:0045930;regulation of mitotic cell cycle phase transition#GO:1901990;regulation of G1/S transition of mitotic cell cycle#GO:2000045;regulation of cell cycle process#GO:0010564;biological regulation#GO:0065007;negative regulation of mitotic cell cycle phase transition#GO:1901991;regulation of mitotic cell cycle#GO:0007346;cellular process#GO:0009987;cellular developmental process#GO:0048869;negative regulation of cell cycle#GO:0045786;negative regulation of cell cycle process#GO:0010948;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523 organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694;chromatin#GO:0000785;membraneless organelle#GO:0043228;transcription regulator complex#GO:0005667;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=6770|UniProtKB=Q13485 Q13485 SMAD4 PTHR13703:SF63 SMAD SMAD FAMILY MEMBER 4 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;protein binding#GO:0005515;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;developmental process#GO:0032502;response to BMP#GO:0071772;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;cell communication#GO:0007154;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;intracellular signal transduction#GO:0035556;response to transforming growth factor beta#GO:0071559;regulation of macromolecule metabolic process#GO:0060255;response to growth factor#GO:0070848;regulation of cellular process#GO:0050794;BMP signaling pathway#GO:0030509;cellular response to transforming growth factor beta stimulus#GO:0071560;cellular response to stimulus#GO:0051716;cellular response to BMP stimulus#GO:0071773;cell surface receptor signaling pathway#GO:0007166;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;intracellular signaling cassette#GO:0141124;transforming growth factor beta receptor signaling pathway#GO:0007179;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to growth factor stimulus#GO:0071363;cell differentiation#GO:0030154;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;cellular response to endogenous stimulus#GO:0071495;signaling#GO:0023052;response to endogenous stimulus#GO:0009719;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789 RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 Wnt signaling pathway#P00057>Smad4#P01455;Gonadotropin-releasing hormone receptor pathway#P06664>SMAD2-4#P06819;TGF-beta signaling pathway#P00052>Co-Smads#P01276 HUMAN|HGNC=24527|UniProtKB=A5PLN7 A5PLN7 FAM149A PTHR31997:SF2 AGAP003710-PA PROTEIN FAM149A HUMAN|HGNC=15042|UniProtKB=Q8NGW1 Q8NGW1 OR6B3 PTHR26452:SF222 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 6B2-RELATED transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606;sensory perception#GO:0007600;nervous system process#GO:0050877 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=17874|UniProtKB=P62310 P62310 LSM3 PTHR13110:SF15 U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM3 U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM3 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 mRNA splicing, via spliceosome#GO:0000398;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170 nuclear protein-containing complex#GO:0140513;Sm-like protein family complex#GO:0120114;membraneless organelle#GO:0043228;catalytic step 2 spliceosome#GO:0071013;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;U4/U6 x U5 tri-snRNP complex#GO:0046540;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;protein-containing complex#GO:0032991;nucleus#GO:0005634;small nuclear ribonucleoprotein complex#GO:0030532;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;spliceosomal snRNP complex#GO:0097525;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;spliceosomal tri-snRNP complex#GO:0097526;P-body#GO:0000932;ribonucleoprotein complex#GO:1990904;precatalytic spliceosome#GO:0071011;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;spliceosomal complex#GO:0005681 RNA splicing factor#PC00148;RNA metabolism protein#PC00031;RNA processing factor#PC00147 HUMAN|HGNC=29918|UniProtKB=Q9BU61 Q9BU61 NDUFAF3 PTHR21192:SF2 NUCLEAR PROTEIN E3-3 NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 3 mitochondrial respiratory chain complex I assembly#GO:0032981;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;cellular component assembly#GO:0022607;mitochondrial respiratory chain complex assembly#GO:0033108;mitochondrion organization#GO:0007005;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;NADH dehydrogenase complex assembly#GO:0010257 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=13879|UniProtKB=Q8N1T3 Q8N1T3 MYO1H PTHR13140:SF353 MYOSIN UNCONVENTIONAL MYOSIN-IH cytoskeletal motor activity#GO:0003774;isomerase activity#GO:0016853;microfilament motor activity#GO:0000146;catalytic activity#GO:0003824;polypeptide conformation or assembly isomerase activity#GO:0120544;ATP-dependent activity#GO:0140657;macromolecular conformation isomerase activity#GO:0120543 transport#GO:0006810;actin filament-based process#GO:0030029;actin filament organization#GO:0007015;supramolecular fiber organization#GO:0097435;import into cell#GO:0098657;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;localization#GO:0051179;actin filament-based movement#GO:0030048;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;endocytosis#GO:0006897 cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;cell periphery#GO:0071944;membrane#GO:0016020;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;actin-based cell projection#GO:0098858;microvillus#GO:0005902;actin cytoskeleton#GO:0015629;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165 actin binding motor protein#PC00040 HUMAN|HGNC=8973|UniProtKB=O75747 O75747 PIK3C2G PTHR10048:SF29 PHOSPHATIDYLINOSITOL KINASE PHOSPHATIDYLINOSITOL 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphatidylinositol kinase activity#GO:0052742;transferase activity#GO:0016740;catalytic activity#GO:0003824;lipid kinase activity#GO:0001727;phosphotransferase activity, alcohol group as acceptor#GO:0016773 phosphatidylinositol phosphate biosynthetic process#GO:0046854;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;organophosphate biosynthetic process#GO:0090407;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;signaling#GO:0023052;phospholipid metabolic process#GO:0006644;glycerolipid metabolic process#GO:0046486;response to stimulus#GO:0050896;phospholipid biosynthetic process#GO:0008654;cell motility#GO:0048870;regulation of cellular process#GO:0050794;glycerophospholipid biosynthetic process#GO:0046474;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0043491;signal transduction#GO:0007165;glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;biosynthetic process#GO:0009058;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124;glycerophospholipid metabolic process#GO:0006650;cell migration#GO:0016477;lipid biosynthetic process#GO:0008610 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 kinase#PC00137 T cell activation#P00053>PI3K#P01322;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PI3K#P00868;p53 pathway feedback loops 2#P04398>PI3K#P04661;FGF signaling pathway#P00021>PI3K#P00640;Integrin signalling pathway#P00034>PI3K#P00936;VEGF signaling pathway#P00056>PI3K#P01413;Axon guidance mediated by netrin#P00009>PI3K#P00363;Angiogenesis#P00005>PI3K#P00236;Endothelin signaling pathway#P00019>PI3K#P00577;p53 pathway#P00059>PI3K#P04609;EGF receptor signaling pathway#P00018>PI3K#P00557;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>PI3K#P00900;Hypoxia response via HIF activation#P00030>PI3K#P00823 HUMAN|HGNC=27884|UniProtKB=Q4V9L6 Q4V9L6 TMEM119 PTHR28645:SF1 TRANSMEMBRANE PROTEIN 119 TRANSMEMBRANE PROTEIN 119 positive regulation of developmental process#GO:0051094;positive regulation of cell differentiation#GO:0045597;regulation of cell differentiation#GO:0045595;regulation of cell population proliferation#GO:0042127;positive regulation of cell population proliferation#GO:0008284;positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789;positive regulation of cellular process#GO:0048522;regulation of multicellular organismal development#GO:2000026;positive regulation of multicellular organismal process#GO:0051240;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of developmental process#GO:0050793;regulation of bone mineralization#GO:0030500;regulation of multicellular organismal process#GO:0051239 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HUMAN|HGNC=27272|UniProtKB=Q5JUX0 Q5JUX0 SPIN3 PTHR10405:SF33 SPINDLIN SPINDLIN-3 protein-macromolecule adaptor activity#GO:0030674;histone H3 reader activity#GO:0140006;molecular adaptor activity#GO:0060090;histone reader activity#GO:0140566;chromatin-protein adaptor activity#GO:0140463 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=27339|UniProtKB=Q8NCU8 Q8NCU8 MTLN PTHR37154:SF1 MITOREGULIN MITOREGULIN mitochondrial inner membrane#GO:0005743;organelle envelope#GO:0031967;membrane#GO:0016020;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=10432|UniProtKB=P51812 P51812 RPS6KA3 PTHR24351:SF58 RIBOSOMAL PROTEIN S6 KINASE RIBOSOMAL PROTEIN S6 KINASE ALPHA-3 catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;TOR signaling#GO:0031929;TORC1 signaling#GO:0038202;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 protein modifying enzyme#PC00260 PDGF signaling pathway#P00047>p90RSK#P01142;CCKR signaling map#P06959>RSK1/2#P07153;Interleukin signaling pathway#P00036>p90RSK#P00964;Ras Pathway#P04393>p90RSK#P04541;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>P90 RSK#P00888 HUMAN|HGNC=9672|UniProtKB=Q9HD43 Q9HD43 PTPRH PTHR19134:SF297 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE H phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725 cell communication#GO:0007154;anatomical structure development#GO:0048856;system development#GO:0048731;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;cellular developmental process#GO:0048869;neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;axon development#GO:0061564;axon guidance#GO:0007411;neuron development#GO:0048666;axonogenesis#GO:0007409;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;cell projection organization#GO:0030030;response to stimulus#GO:0050896;cell differentiation#GO:0030154;cell morphogenesis#GO:0000902;signaling#GO:0023052;cell development#GO:0048468;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cell projection morphogenesis#GO:0048858;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;neuron projection development#GO:0031175;signal transduction#GO:0007165;cellular process#GO:0009987 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HUMAN|HGNC=17348|UniProtKB=O43395 O43395 PRPF3 PTHR14212:SF0 U4/U6-ASSOCIATED RNA SPLICING FACTOR-RELATED U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3 metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071 ribonucleoprotein complex#GO:1990904;spliceosomal tri-snRNP complex#GO:0097526;intracellular organelle#GO:0043229;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513;spliceosomal snRNP complex#GO:0097525;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;small nuclear ribonucleoprotein complex#GO:0030532;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;U4/U6 x U5 tri-snRNP complex#GO:0046540;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 RNA splicing factor#PC00148 mRNA splicing#P00058>U6#P01473;mRNA splicing#P00058>U4#P01476 HUMAN|HGNC=30498|UniProtKB=Q8TA94 Q8TA94 ZNF563 PTHR24379:SF14 KRAB AND ZINC FINGER DOMAIN-CONTAINING ZINC FINGER PROTEIN 563 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244;DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=15950|UniProtKB=Q9BWW7 Q9BWW7 SCRT1 PTHR24388:SF60 ZINC FINGER PROTEIN TRANSCRIPTIONAL REPRESSOR SCRATCH 1 transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=13971|UniProtKB=Q9UGF5 Q9UGF5 OR14J1 PTHR26452:SF42 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 14J1 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606;nervous system process#GO:0050877;sensory perception#GO:0007600 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=11394|UniProtKB=O75716 O75716 STK16 PTHR45998:SF9 SERINE/THREONINE-PROTEIN KINASE 16 SERINE_THREONINE-PROTEIN KINASE 16 catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=18364|UniProtKB=Q8IZJ0 Q8IZJ0 IFNL2 PTHR31943:SF1 INTERLEUKIN-28 AND 29 INTERFERON LAMBDA-2-RELATED cytokine activity#GO:0005125;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772 innate immune response#GO:0045087;response to virus#GO:0009615;defense response#GO:0006952;response to external stimulus#GO:0009605;immune system process#GO:0002376;defense response to other organism#GO:0098542;response to stimulus#GO:0050896;response to other organism#GO:0051707;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to stress#GO:0006950;defense response to virus#GO:0051607;response to biotic stimulus#GO:0009607;immune response#GO:0006955;defense response to symbiont#GO:0140546 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207;cytokine#PC00083;interleukin superfamily#PC00128 HUMAN|HGNC=17968|UniProtKB=Q9UNA3 Q9UNA3 A4GNT PTHR12042:SF16 LACTOSYLCERAMIDE 4-ALPHA-GALACTOSYLTRANSFERASE ALPHA- 1,4-GALACTOSYLTRANSFERASE ALPHA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740;acetylglucosaminyltransferase activity#GO:0008375;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757 liposaccharide metabolic process#GO:1903509;glycolipid metabolic process#GO:0006664;primary metabolic process#GO:0044238;glycolipid biosynthetic process#GO:0009247;protein metabolic process#GO:0019538;glycosphingolipid biosynthetic process#GO:0006688;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;protein O-linked glycosylation#GO:0006493;cellular process#GO:0009987;glycoprotein biosynthetic process#GO:0009101;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;glycoprotein metabolic process#GO:0009100;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;sphingolipid metabolic process#GO:0006665;sphingolipid biosynthetic process#GO:0030148 transferase#PC00220;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=20789|UniProtKB=Q86TL0 Q86TL0 ATG4D PTHR22624:SF36 CYSTEINE PROTEASE ATG4 CYSTEINE PROTEASE ATG4D hydrolase activity#GO:0016787;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;cysteine-type endopeptidase activity#GO:0004197;endopeptidase activity#GO:0004175;protein-phosphatidylethanolamide deconjugating activity#GO:0019786 biosynthetic process#GO:0009058;macroautophagy#GO:0016236;cellular component assembly#GO:0022607;protein maturation#GO:0051604;gene expression#GO:0010467;autophagy#GO:0006914;autophagosome organization#GO:1905037;protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;autophagosome assembly#GO:0000045;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;mitophagy#GO:0000423;metabolic process#GO:0008152;autophagy of mitochondrion#GO:0000422;piecemeal microautophagy of the nucleus#GO:0034727;catabolic process#GO:0009056;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;vacuole organization#GO:0007033;process utilizing autophagic mechanism#GO:0061919;protein metabolic process#GO:0019538;organelle assembly#GO:0070925;proteolysis#GO:0006508 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 cysteine protease#PC00081 HUMAN|HGNC=864|UniProtKB=O75348 O75348 ATP6V1G1 PTHR12713:SF12 VACUOLAR ATP SYNTHASE SUBUNIT G V-TYPE PROTON ATPASE SUBUNIT G 1 homeostatic process#GO:0042592;cellular component organization#GO:0016043;monoatomic cation transport#GO:0006812;localization#GO:0051179;cellular localization#GO:0051641;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;developmental maturation#GO:0021700;vesicle-mediated transport#GO:0016192;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;organelle organization#GO:0006996;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;synaptic vesicle maturation#GO:0016188;cellular component organization or biogenesis#GO:0071840;proton transmembrane transport#GO:1902600;establishment of localization#GO:0051234;vesicle-mediated transport in synapse#GO:0099003;vesicle organization#GO:0016050;cellular homeostasis#GO:0019725;developmental process#GO:0032502;synaptic vesicle cycle#GO:0099504;transport#GO:0006810 secretory vesicle#GO:0099503;presynapse#GO:0098793;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;vacuole#GO:0005773;cytoplasm#GO:0005737;proton-transporting two-sector ATPase complex#GO:0016469;cell junction#GO:0030054;transporter complex#GO:1990351;bounding membrane of organelle#GO:0098588;intracellular vesicle#GO:0097708;organelle#GO:0043226;cellular anatomical structure#GO:0110165;synapse#GO:0045202;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;ATPase complex#GO:1904949;ATPase dependent transmembrane transport complex#GO:0098533;vesicle membrane#GO:0012506;membrane#GO:0016020;transport vesicle#GO:0030133;transport vesicle membrane#GO:0030658;endomembrane system#GO:0012505;vacuolar membrane#GO:0005774;proton-transporting V-type ATPase complex#GO:0033176;organelle membrane#GO:0031090;membrane protein complex#GO:0098796;synaptic vesicle membrane#GO:0030672;vesicle#GO:0031982;cation-transporting ATPase complex#GO:0090533;synaptic vesicle#GO:0008021;vacuolar proton-transporting V-type ATPase, V1 domain#GO:0000221;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;vacuolar proton-transporting V-type ATPase complex#GO:0016471;transmembrane transporter complex#GO:1902495;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622 ATP synthase#PC00002 HUMAN|HGNC=861|UniProtKB=Q99437 Q99437 ATP6V0B PTHR10263:SF18 V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT V-TYPE PROTON ATPASE 21 KDA PROTEOLIPID SUBUNIT C'' cellular anatomical structure#GO:0110165;membrane#GO:0016020 ATP synthase#PC00002;primary active transporter#PC00068 HUMAN|HGNC=26328|UniProtKB=A6NJ46 A6NJ46 NKX6-3 PTHR24340:SF20 HOMEOBOX PROTEIN NKX HOMEOBOX PROTEIN NKX-6.3 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of biological process#GO:0050789;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=17499|UniProtKB=Q9UGK8 Q9UGK8 SERGEF PTHR45622:SF78 UBIQUITIN-PROTEIN LIGASE E3A-RELATED SECRETION-REGULATING GUANINE NUCLEOTIDE EXCHANGE FACTOR ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740 negative regulation of cellular process#GO:0048523;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;negative regulation of protein transport#GO:0051224;biological regulation#GO:0065007;post-translational protein modification#GO:0043687;regulation of establishment of protein localization#GO:0070201;regulation of secretion#GO:0051046;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;modification-dependent protein catabolic process#GO:0019941;regulation of protein secretion#GO:0050708;primary metabolic process#GO:0044238;protein modification process#GO:0036211;negative regulation of transport#GO:0051051;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;regulation of transport#GO:0051049;regulation of localization#GO:0032879;cellular process#GO:0009987;protein ubiquitination#GO:0016567;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein modification by small protein conjugation or removal#GO:0070647;regulation of protein localization#GO:0032880;regulation of secretion by cell#GO:1903530;regulation of biological process#GO:0050789;protein modification by small protein conjugation#GO:0032446;negative regulation of biological process#GO:0048519;regulation of protein transport#GO:0051223 nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=28280|UniProtKB=Q6ZRR5 Q6ZRR5 TLCD5 PTHR31898:SF1 TRANSMEMBRANE PROTEIN 136 TLC DOMAIN-CONTAINING PROTEIN 5 HUMAN|HGNC=8882|UniProtKB=P35080 P35080 PFN2 PTHR13936:SF15 PROFILIN PROFILIN-2 protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;binding#GO:0005488 cellular component organization or biogenesis#GO:0071840;positive regulation of actin filament bundle assembly#GO:0032233;regulation of anatomical structure size#GO:0090066;regulation of actin filament-based process#GO:0032970;regulation of actin filament polymerization#GO:0030833;positive regulation of cellular component biogenesis#GO:0044089;biological regulation#GO:0065007;regulation of actin polymerization or depolymerization#GO:0008064;regulation of actin cytoskeleton organization#GO:0032956;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;regulation of actin filament organization#GO:0110053;positive regulation of organelle organization#GO:0010638;regulation of biological quality#GO:0065008;regulation of actin filament length#GO:0030832;positive regulation of cellular component organization#GO:0051130;regulation of cellular component organization#GO:0051128;regulation of protein polymerization#GO:0032271;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794;regulation of stress fiber assembly#GO:0051492;regulation of cellular component biogenesis#GO:0044087;regulation of actin filament bundle assembly#GO:0032231;cellular component organization#GO:0016043;regulation of protein-containing complex assembly#GO:0043254;regulation of cellular component size#GO:0032535;regulation of supramolecular fiber organization#GO:1902903;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 non-motor actin binding protein#PC00165;actin or actin-binding cytoskeletal protein#PC00041 Cytoskeletal regulation by Rho GTPase#P00016>Profilin#P00521 HUMAN|HGNC=17050|UniProtKB=Q9UNX3 Q9UNX3 RPL26L1 PTHR11143:SF10 60S RIBOSOMAL PROTEIN L26 FAMILY MEMBER RIBOSOMAL PROTEIN UL24-LIKE structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 metabolic process#GO:0008152;translation#GO:0006412;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cytoplasmic translation#GO:0002181;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;biosynthetic process#GO:0009058 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625;cytosol#GO:0005829 ribosomal protein#PC00202;translational protein#PC00263 HUMAN|HGNC=30660|UniProtKB=Q9UBE0 Q9UBE0 SAE1 PTHR10953:SF201 UBIQUITIN-ACTIVATING ENZYME E1 SUMO-ACTIVATING ENZYME SUBUNIT 1 nucleotidyltransferase activity#GO:0016779;catalytic activity#GO:0003824;transferase activity#GO:0016740;ligase activity#GO:0016874;transferase activity, transferring phosphorus-containing groups#GO:0016772;ubiquitin-like modifier activating enzyme activity#GO:0008641;catalytic activity, acting on a protein#GO:0140096;ligase activity, forming carbon-sulfur bonds#GO:0016877;ATP-dependent activity#GO:0140657;thiosulfate-cyanide sulfurtransferase activity#GO:0004792;sulfurtransferase activity#GO:0016783;transferase activity, transferring sulphur-containing groups#GO:0016782 cellular process#GO:0009987;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;protein modification process#GO:0036211;post-translational protein modification#GO:0043687;metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647;protein sumoylation#GO:0016925;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;catalytic complex#GO:1902494 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 Ubiquitin proteasome pathway#P00060>E1#P01492 HUMAN|HGNC=23161|UniProtKB=Q9BVK2 Q9BVK2 ALG8 PTHR12413:SF2 DOLICHYL GLYCOSYLTRANSFERASE DOLICHYL PYROPHOSPHATE GLC1MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE glycosyltransferase activity#GO:0016757;glucosyltransferase activity#GO:0046527;transferase activity#GO:0016740;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 glycoprotein biosynthetic process#GO:0009101;protein N-linked glycosylation#GO:0006487;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;biosynthetic process#GO:0009058;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538 endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;membrane#GO:0016020;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 metabolite interconversion enzyme#PC00262;glycosyltransferase#PC00111 HUMAN|HGNC=4837|UniProtKB=P53701 P53701 HCCS PTHR12743:SF0 CYTOCHROME C1 HEME LYASE HOLOCYTOCHROME C-TYPE SYNTHASE lyase activity#GO:0016829;catalytic activity, acting on a protein#GO:0140096;carbon-sulfur lyase activity#GO:0016846;catalytic activity#GO:0003824 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 lyase#PC00144 HUMAN|HGNC=683|UniProtKB=Q9NR81 Q9NR81 ARHGEF3 PTHR46006:SF2 RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 3 regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;positive regulation of signaling#GO:0023056;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of Rho protein signal transduction#GO:0035023;positive regulation of cell communication#GO:0010647;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;regulation of small GTPase mediated signal transduction#GO:0051056;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of response to stimulus#GO:0048584 G-protein modulator#PC00022;protein-binding activity modulator#PC00095;guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=7090|UniProtKB=Q29983 Q29983 MICA PTHR16675:SF154 MHC CLASS I-RELATED MHC CLASS I POLYPEPTIDE-RELATED SEQUENCE A-RELATED protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102;antigen binding#GO:0003823;peptide binding#GO:0042277 immune system process#GO:0002376;regulation of lymphocyte mediated immunity#GO:0002706;regulation of immune response#GO:0050776;regulation of cell killing#GO:0031341;cell activation#GO:0001775;positive regulation of lymphocyte mediated immunity#GO:0002708;antigen processing and presentation#GO:0019882;regulation of immune effector process#GO:0002697;regulation of leukocyte mediated cytotoxicity#GO:0001910;leukocyte activation#GO:0045321;T cell activation#GO:0042110;regulation of biological process#GO:0050789;regulation of leukocyte mediated immunity#GO:0002703;positive regulation of adaptive immune response#GO:0002821;response to stimulus#GO:0050896;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;positive regulation of leukocyte mediated immunity#GO:0002705;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;positive regulation of immune system process#GO:0002684;immune response#GO:0006955;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;lymphocyte activation#GO:0046649;positive regulation of response to stimulus#GO:0048584;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;positive regulation of immune effector process#GO:0002699 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;external side of plasma membrane#GO:0009897;extracellular region#GO:0005576;side of membrane#GO:0098552 major histocompatibility complex protein#PC00149;defense/immunity protein#PC00090 HUMAN|HGNC=5464|UniProtKB=P05019 P05019 IGF1 PTHR46845:SF1 INSULIN-LIKE GROWTH FACTOR I INSULIN-LIKE GROWTH FACTOR 1 signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;binding#GO:0005488;signaling receptor binding#GO:0005102;molecular function activator activity#GO:0140677;hormone activity#GO:0005179;protein binding#GO:0005515 positive regulation of signaling#GO:0023056;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;insulin-like growth factor receptor signaling pathway#GO:0048009;response to stimulus#GO:0050896;positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051897;signaling#GO:0023052;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;positive regulation of cell population proliferation#GO:0008284;regulation of biological process#GO:0050789;regulation of apoptotic process#GO:0042981;cell surface receptor signaling pathway#GO:0007166;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;negative regulation of programmed cell death#GO:0043069;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051896;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cell population proliferation#GO:0008283;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of cell communication#GO:0010646;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;negative regulation of apoptotic process#GO:0043066;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of cellular process#GO:0048522 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207;growth factor#PC00112 Gonadotropin-releasing hormone receptor pathway#P06664>IGF-1#P06854;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>Insulin IGF#P00882;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>Insulin IGF#P00896 HUMAN|HGNC=2897|UniProtKB=Q96QB1 Q96QB1 DLC1 PTHR12659:SF2 RHO-TYPE GTPASE ACTIVATING PROTEIN RHO GTPASE-ACTIVATING PROTEIN 7 molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;enzyme activator activity#GO:0008047 biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;cytoskeleton organization#GO:0007010;cellular process#GO:0009987;organelle organization#GO:0006996;regulation of small GTPase mediated signal transduction#GO:0051056;cellular component organization or biogenesis#GO:0071840;regulation of response to stimulus#GO:0048583;regulation of cell communication#GO:0010646;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;regulation of Rho protein signal transduction#GO:0035023;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;regulation of signaling#GO:0023051;actin filament-based process#GO:0030029;regulation of intracellular signal transduction#GO:1902531 anchoring junction#GO:0070161;cell junction#GO:0030054;membrane microdomain#GO:0098857;focal adhesion#GO:0005925;cell-substrate junction#GO:0030055;cellular anatomical structure#GO:0110165;membrane#GO:0016020;membrane raft#GO:0045121 G-protein modulator#PC00022;GTPase-activating protein#PC00257 PDGF signaling pathway#P00047>Rho#P01174 HUMAN|HGNC=21238|UniProtKB=Q8N7C4 Q8N7C4 TMEM217 PTHR34928:SF2 TRANSMEMBRANE PROTEIN 217 TRANSMEMBRANE PROTEIN 217 HUMAN|Gene=YV023_HUMAN|UniProtKB=A8MUU9 A8MUU9 PTHR35683:SF7 YALI0C04136P APPLE DOMAIN-CONTAINING PROTEIN HUMAN|HGNC=8849|UniProtKB=O75879 O75879 GATB PTHR11659:SF5 GLUTAMYL-TRNA GLN AMIDOTRANSFERASE SUBUNIT B MITOCHONDRIAL AND PROKARYOTIC PET112-RELATED GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT B, MITOCHONDRIAL catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;ligase activity#GO:0016874;ligase activity, forming carbon-nitrogen bonds#GO:0016879;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a tRNA#GO:0140101 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mitochondrial translation#GO:0032543;protein biosynthetic process#GO:0160307;translation#GO:0006412;mitochondrial gene expression#GO:0140053;protein metabolic process#GO:0019538;RNA metabolic process#GO:0016070;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;tRNA aminoacylation#GO:0043039;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;amino acid metabolic process#GO:0006520;gene expression#GO:0010467;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;macromolecule metabolic process#GO:0043170;amino acid activation#GO:0043038 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 ligase#PC00142;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=25115|UniProtKB=Q9BUA3 Q9BUA3 SPINDOC PTHR34589:SF1 SIMILAR TO RIKEN CDNA 2700081O15 SPINDLIN INTERACTOR AND REPRESSOR OF CHROMATIN-BINDING PROTEIN regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 HUMAN|HGNC=9110|UniProtKB=Q16048 Q16048 PMCHL1 PTHR12091:SF1 MELANIN-CONCENTRATING HORMONE PRO-MCH-LIKE PROTEIN 1-RELATED protein binding#GO:0005515;neuropeptide receptor binding#GO:0071855;binding#GO:0005488;signaling receptor binding#GO:0005102;G protein-coupled receptor binding#GO:0001664 regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of cell communication#GO:0010646;biological regulation#GO:0065007;modulation of chemical synaptic transmission#GO:0050804;regulation of trans-synaptic signaling#GO:0099177;regulation of cellular process#GO:0050794;regulation of signaling#GO:0023051;negative regulation of cellular process#GO:0048523;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648 intercellular signal molecule#PC00207;peptide hormone#PC00179 HUMAN|HGNC=9658|UniProtKB=P29350 P29350 PTPN6 PTHR46257:SF4 TYROSINE-PROTEIN PHOSPHATASE CORKSCREW TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 6 phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787;protein binding#GO:0005515;protein tyrosine phosphatase activity#GO:0004725;binding#GO:0005488;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 cellular developmental process#GO:0048869;mitotic cell cycle#GO:0000278;cell differentiation#GO:0030154;cell cycle#GO:0007049;cellular process#GO:0009987;developmental process#GO:0032502 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195;protein modifying enzyme#PC00260 Interferon-gamma signaling pathway#P00035>PTP#P00960;Angiogenesis#P00005>SHP2#P00181;FGF signaling pathway#P00021>SHP2#P00647;B cell activation#P00010>SHP-1#P00378 HUMAN|HGNC=33606|UniProtKB=A0A1W2PRG0 A0A1W2PRG0 GSTTP2 PTHR43917:SF13 FAMILY NOT NAMED GLUTATHIONE S-TRANSFERASE THETA-4 transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;glutathione transferase activity#GO:0004364;catalytic activity#GO:0003824;transferase activity#GO:0016740 cellular process#GO:0009987;modified amino acid metabolic process#GO:0006575;glutathione metabolic process#GO:0006749;sulfur compound metabolic process#GO:0006790;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 transferase#PC00220 HUMAN|HGNC=18910|UniProtKB=Q9BYQ8 Q9BYQ8 KRTAP4-9 PTHR23262:SF203 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 4-9 structural protein#PC00211 HUMAN|HGNC=15565|UniProtKB=Q96P65 Q96P65 QRFPR PTHR24241:SF119 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR PYROGLUTAMYLATED RF-AMIDE PEPTIDE RECEPTOR signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 signaling#GO:0023052;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cellular response to hormone stimulus#GO:0032870;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to endogenous stimulus#GO:0009719;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887;biological regulation#GO:0065007;response to chemical#GO:0042221;signal transduction#GO:0007165;cellular process#GO:0009987;response to hormone#GO:0009725 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=25990|UniProtKB=Q9C0C7 Q9C0C7 AMBRA1 PTHR22874:SF1 ACTIVATING MOLECULE IN BECN1-REGULATED AUTOPHAGY PROTEIN 1 ACTIVATING MOLECULE IN BECN1-REGULATED AUTOPHAGY PROTEIN 1 enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 autophagy of mitochondrion#GO:0000422;metabolic process#GO:0008152;autophagosome assembly#GO:0000045;mitophagy#GO:0000423;cellular component organization or biogenesis#GO:0071840;autophagosome organization#GO:1905037;cellular process#GO:0009987;autophagy#GO:0006914;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;macroautophagy#GO:0016236;cellular component assembly#GO:0022607;organelle assembly#GO:0070925;process utilizing autophagic mechanism#GO:0061919;vacuole organization#GO:0007033;cellular component organization#GO:0016043;catabolic process#GO:0009056 cullin-RING ubiquitin ligase complex#GO:0031461;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;ubiquitin ligase complex#GO:0000151;intracellular organelle#GO:0043229;transferase complex#GO:1990234;catalytic complex#GO:1902494;Cul4-RING E3 ubiquitin ligase complex#GO:0080008 HUMAN|HGNC=15143|UniProtKB=A6NM03 A6NM03 OR2AG2 PTHR26453:SF607 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2AG2 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 system process#GO:0003008;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;sensory perception#GO:0007600;nervous system process#GO:0050877;response to chemical#GO:0042221;response to stimulus#GO:0050896;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;detection of chemical stimulus#GO:0009593 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=30677|UniProtKB=Q92917 Q92917 GPKOW PTHR15818:SF2 G PATCH AND KOW-CONTAINING G-PATCH DOMAIN AND KOW MOTIFS-CONTAINING PROTEIN primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;spliceosomal complex#GO:0005681 RNA splicing factor#PC00148 HUMAN|HGNC=17677|UniProtKB=Q15276 Q15276 RABEP1 PTHR31179:SF5 RAB GTPASE-BINDING EFFECTOR PROTEIN RAB GTPASE-BINDING EFFECTOR PROTEIN 1 Golgi to plasma membrane transport#GO:0006893;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;post-Golgi vesicle-mediated transport#GO:0006892;vesicle-mediated transport to the plasma membrane#GO:0098876;localization within membrane#GO:0051668;Golgi vesicle transport#GO:0048193;transport#GO:0006810 endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endocytic vesicle#GO:0030139;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=6284|UniProtKB=Q12791 Q12791 KCNMA1 PTHR10027:SF28 CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1 potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;calcium-activated cation channel activity#GO:0005227;potassium channel activity#GO:0005267;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation channel activity#GO:0005261;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;calcium-activated potassium channel activity#GO:0015269;monoatomic ion-gated channel activity#GO:0022839;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;monoatomic cation transmembrane transporter activity#GO:0008324;gated channel activity#GO:0022836;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;transporter activity#GO:0005215 regulation of anatomical structure size#GO:0090066;transport#GO:0006810;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;system process#GO:0003008;cellular process#GO:0009987;multicellular organismal process#GO:0032501;blood circulation#GO:0008015;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;potassium ion transmembrane transport#GO:0071805;biological regulation#GO:0065007;monoatomic cation transmembrane transport#GO:0098655;circulatory system process#GO:0003013;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;vasodilation#GO:0042311;metal ion transport#GO:0030001 plasma membrane region#GO:0098590;synapse#GO:0045202;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;postsynapse#GO:0098794;membrane#GO:0016020;cell periphery#GO:0071944;cell junction#GO:0030054;postsynaptic membrane#GO:0045211;synaptic membrane#GO:0097060 ion channel#PC00133;transporter#PC00227 HUMAN|HGNC=11722|UniProtKB=Q10587 Q10587 TEF PTHR11988:SF24 THYROTROPH EMBRYONIC FACTOR RELATED THYROTROPH EMBRYONIC FACTOR sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of transcription by RNA polymerase II#GO:0045944;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;basic leucine zipper transcription factor#PC00056 HUMAN|HGNC=14968|UniProtKB=Q9BXA7 Q9BXA7 TSSK1B PTHR24343:SF76 SERINE/THREONINE KINASE TESTIS-SPECIFIC SERINE_THREONINE-PROTEIN KINASE 1 transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 reproductive process#GO:0022414;cell development#GO:0048468;cellular process involved in reproduction in multicellular organism#GO:0022412;cell differentiation#GO:0030154;gamete generation#GO:0007276;germ cell development#GO:0007281;developmental process involved in reproduction#GO:0003006;multicellular organismal reproductive process#GO:0048609;anatomical structure development#GO:0048856;sexual reproduction#GO:0019953;spermatid development#GO:0007286;spermatid differentiation#GO:0048515;male gamete generation#GO:0048232;cellular process#GO:0009987;cellular developmental process#GO:0048869;developmental process#GO:0032502;spermatogenesis#GO:0007283 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=19662|UniProtKB=Q7RTV2 Q7RTV2 GSTA5 PTHR11571:SF245 GLUTATHIONE S-TRANSFERASE GLUTATHIONE S-TRANSFERASE A5 transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;transferase activity#GO:0016740;catalytic activity#GO:0003824;glutathione transferase activity#GO:0004364 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;modified amino acid metabolic process#GO:0006575;sulfur compound metabolic process#GO:0006790;xenobiotic metabolic process#GO:0006805;cellular response to xenobiotic stimulus#GO:0071466;response to stimulus#GO:0050896;response to chemical#GO:0042221;cellular response to chemical stimulus#GO:0070887;response to xenobiotic stimulus#GO:0009410;metabolic process#GO:0008152;glutathione metabolic process#GO:0006749 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 transferase#PC00220 HUMAN|HGNC=30711|UniProtKB=Q8IWG1 Q8IWG1 DNAI3 PTHR12442:SF5 DYNEIN INTERMEDIATE CHAIN DYNEIN AXONEMAL INTERMEDIATE CHAIN 3 binding#GO:0005488;protein binding#GO:0005515 cell projection organization#GO:0030030;microtubule-based movement#GO:0007018;cell motility#GO:0048870;cellular component organization#GO:0016043;cilium assembly#GO:0060271;protein-containing complex assembly#GO:0065003;cilium-dependent cell motility#GO:0060285;microtubule cytoskeleton organization#GO:0000226;axoneme assembly#GO:0035082;cilium organization#GO:0044782;organelle assembly#GO:0070925;inner dynein arm assembly#GO:0036159;cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;axonemal dynein complex assembly#GO:0070286;microtubule bundle formation#GO:0001578;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection organization#GO:0120036;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cilium movement involved in cell motility#GO:0060294;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;protein-containing complex organization#GO:0043933;plasma membrane bounded cell projection assembly#GO:0120031 cilium#GO:0005929;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;axoneme#GO:0005930;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;axonemal dynein complex#GO:0005858;dynein complex#GO:0030286;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cytoskeleton#GO:0005856;inner dynein arm#GO:0036156;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;ciliary plasm#GO:0097014;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737 microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=30887|UniProtKB=Q9UL33 Q9UL33 TRAPPC2L PTHR12403:SF25 TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2 TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2-LIKE PROTEIN cytosolic transport#GO:0016482;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;retrograde transport, endosome to Golgi#GO:0042147;endosomal transport#GO:0016197;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;Golgi vesicle transport#GO:0048193;transport#GO:0006810;intracellular transport#GO:0046907 vesicle tethering complex#GO:0099023;intracellular protein-containing complex#GO:0140535;Golgi apparatus#GO:0005794;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasm#GO:0005737;TRAPP complex#GO:0030008;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endosome#GO:0005768;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;TRAPPII protein complex#GO:1990071 membrane traffic protein#PC00150 HUMAN|HGNC=4045|UniProtKB=O75084 O75084 FZD7 PTHR11309:SF31 FRIZZLED FRIZZLED-7 signaling receptor activity#GO:0038023;protein binding#GO:0005515;molecular transducer activity#GO:0060089;Wnt-protein binding#GO:0017147;transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488 cell communication#GO:0007154;canonical Wnt signaling pathway#GO:0060070;cell surface receptor signaling pathway#GO:0007166;response to stimulus#GO:0050896;Wnt signaling pathway#GO:0016055;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;non-canonical Wnt signaling pathway#GO:0035567;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 Cadherin signaling pathway#P00012>Frizzled#P00475;Alzheimer disease-presenilin pathway#P00004>Frizzled#P00119;Wnt signaling pathway#P00057>Frizzled#P01428 HUMAN|HGNC=5658|UniProtKB=A0A075B7B6 A0A075B7B6 IGHV4OR15-8 PTHR23266:SF387 IMMUNOGLOBULIN HEAVY CHAIN IG-LIKE DOMAIN-CONTAINING PROTEIN-RELATED antigen binding#GO:0003823;binding#GO:0005488 immune system process#GO:0002376;immune effector process#GO:0002252;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;immunoglobulin mediated immune response#GO:0016064;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immune response#GO:0006955;response to stimulus#GO:0050896;adaptive immune response#GO:0002250 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=53857|UniProtKB=A0A1W2PPL8 A0A1W2PPL8 TAF11L14 PTHR13218:SF15 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11-RELATED TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 11 LIKE PROTEIN 2-RELATED RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;RNA polymerase II preinitiation complex assembly#GO:0051123;DNA-templated transcription initiation#GO:0006352;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;protein-DNA complex assembly#GO:0065004;cellular component assembly#GO:0022607;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;transcription initiation at RNA polymerase II promoter#GO:0006367;protein-containing complex organization#GO:0043933;macromolecule metabolic process#GO:0043170;protein-DNA complex organization#GO:0071824;cellular component organization or biogenesis#GO:0071840;transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654 nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;RNA polymerase II, holoenzyme#GO:0016591;membrane-bounded organelle#GO:0043227;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;transcription factor TFIID complex#GO:0005669;RNA polymerase II transcription regulator complex#GO:0090575;membrane-enclosed lumen#GO:0031974;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;transcription regulator complex#GO:0005667;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234 general transcription factor#PC00259;RNA metabolism protein#PC00031 Transcription regulation by bZIP transcription factor#P00055>TBP-associated factors#P01385;General transcription regulation#P00023>TBP-associated factors#P00658 HUMAN|HGNC=3540|UniProtKB=Q96RI0 Q96RI0 F2RL3 PTHR24232:SF22 G-PROTEIN COUPLED RECEPTOR PROTEINASE-ACTIVATED RECEPTOR 4 signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 Blood coagulation#P00011>PAR-4#P00461 HUMAN|HGNC=21649|UniProtKB=Q9UHR4 Q9UHR4 BAIAP2L1 PTHR14206:SF4 BRAIN-SPECIFIC ANGIOGENESIS INHIBITOR 1-ASSOCIATED PROTEIN 2 BAR_IMD DOMAIN-CONTAINING ADAPTER PROTEIN 2-LIKE 1 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 regulation of protein polymerization#GO:0032271;regulation of cytoskeleton organization#GO:0051493;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;actin filament bundle assembly#GO:0051017;regulation of supramolecular fiber organization#GO:1902903;supramolecular fiber organization#GO:0097435;actin filament-based process#GO:0030029;regulation of actin polymerization or depolymerization#GO:0008064;biological regulation#GO:0065007;positive regulation of protein polymerization#GO:0032273;regulation of actin filament polymerization#GO:0030833;positive regulation of cellular process#GO:0048522;regulation of actin filament organization#GO:0110053;actin filament organization#GO:0007015;regulation of actin filament-based process#GO:0032970;regulation of cellular component biogenesis#GO:0044087;regulation of cellular component organization#GO:0051128;regulation of cellular component size#GO:0032535;regulation of biological process#GO:0050789;actin filament bundle organization#GO:0061572;regulation of organelle organization#GO:0033043;regulation of protein-containing complex assembly#GO:0043254;cellular component organization#GO:0016043;regulation of biological quality#GO:0065008;positive regulation of organelle organization#GO:0010638;regulation of actin filament length#GO:0030832;positive regulation of cellular component organization#GO:0051130;cytoskeleton organization#GO:0007010;regulation of actin cytoskeleton organization#GO:0032956;cellular component assembly#GO:0022607;positive regulation of cellular component biogenesis#GO:0044089;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular component organization or biogenesis#GO:0071840;regulation of anatomical structure size#GO:0090066 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HUMAN|HGNC=24303|UniProtKB=Q8NDT2 Q8NDT2 RBM15B PTHR23189:SF40 RNA RECOGNITION MOTIF-CONTAINING RNA-BINDING PROTEIN 15B-RELATED RNA binding#GO:0003723;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of mRNA processing#GO:0050684;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of mRNA metabolic process#GO:1903311;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of alternative mRNA splicing, via spliceosome#GO:0000381;regulation of RNA metabolic process#GO:0051252 RNA metabolism protein#PC00031 HUMAN|HGNC=5178|UniProtKB=P23327 P23327 HRC PTHR15054:SF3 HISTIDINE-RICH CALCIUM-BINDING PROTEIN-RELATED SARCOPLASMIC RETICULUM HISTIDINE-RICH CALCIUM-BINDING PROTEIN molecular sequestering activity#GO:0140313 inorganic ion homeostasis#GO:0098771;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;regulation of system process#GO:0044057;calcium ion homeostasis#GO:0055074;biological regulation#GO:0065007;homeostatic process#GO:0042592;regulation of multicellular organismal process#GO:0051239;regulation of heart contraction#GO:0008016;regulation of biological process#GO:0050789;monoatomic ion homeostasis#GO:0050801 sarcoplasm#GO:0016528;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane#GO:0016020;sarcoplasmic reticulum#GO:0016529;sarcoplasmic reticulum membrane#GO:0033017;endomembrane system#GO:0012505;cytoplasm#GO:0005737 HUMAN|HGNC=18471|UniProtKB=Q9NPG8 Q9NPG8 ZDHHC4 PTHR22883:SF466 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE ZDHHC4 catalytic activity, acting on a protein#GO:0140096;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;palmitoyltransferase activity#GO:0016409;catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746 protein targeting to membrane#GO:0006612;localization within membrane#GO:0051668;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;establishment of protein localization to membrane#GO:0090150;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein targeting#GO:0006605 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 protein modifying enzyme#PC00260 HUMAN|HGNC=11197|UniProtKB=Q9Y651 Q9Y651 SOX21 PTHR10270:SF313 SOX TRANSCRIPTION FACTOR TRANSCRIPTION FACTOR SOX-21 sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;sequence-specific DNA binding#GO:0043565;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription activator activity#GO:0001216;transcription regulator activity#GO:0140110;transcription regulatory region nucleic acid binding#GO:0001067 multicellular organism development#GO:0007275;animal organ development#GO:0048513;positive regulation of transcription by RNA polymerase II#GO:0045944;neuron differentiation#GO:0030182;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;positive regulation of macromolecule metabolic process#GO:0010604;nervous system development#GO:0007399;head development#GO:0060322;negative regulation of macromolecule biosynthetic process#GO:0010558;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;central nervous system development#GO:0007417;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;regulation of nucleobase-containing compound metabolic process#GO:0019219;brain development#GO:0007420;positive regulation of DNA-templated transcription#GO:0045893;multicellular organismal process#GO:0032501;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;negative regulation of biosynthetic process#GO:0009890;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;positive regulation of biosynthetic process#GO:0009891;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;system development#GO:0048731;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;HMG box transcription factor#PC00024;DNA-binding transcription factor#PC00218 HUMAN|HGNC=9189|UniProtKB=P19387 P19387 POLR2C PTHR11800:SF2 DNA-DIRECTED RNA POLYMERASE DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3 transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a nucleic acid#GO:0140640;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on RNA#GO:0140098 gene expression#GO:0010467;RNA biosynthetic process#GO:0032774;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;DNA-templated transcription#GO:0006351;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;transcription by RNA polymerase II#GO:0006366;nucleic acid biosynthetic process#GO:0141187 membrane-enclosed lumen#GO:0031974;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;protein-containing complex#GO:0032991;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle#GO:0043226;RNA polymerase II, core complex#GO:0005665;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;RNA polymerase II, holoenzyme#GO:0016591;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428 DNA-directed RNA polymerase#PC00019 Transcription regulation by bZIP transcription factor#P00055>RNA Polymerase II#P01388;General transcription regulation#P00023>RNA Polymerase II#P00660 HUMAN|HGNC=12617|UniProtKB=O94966 O94966 USP19 PTHR21646:SF24 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 19 peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity, acting on a protein#GO:0140096;cysteine-type deubiquitinase activity#GO:0004843;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005 regulation of protein stability#GO:0031647;regulation of biological quality#GO:0065008;biological regulation#GO:0065007 cysteine protease#PC00081 HUMAN|HGNC=26453|UniProtKB=Q8NHS4 Q8NHS4 CLHC1 PTHR10292:SF11 CLATHRIN HEAVY CHAIN RELATED CLATHRIN HEAVY CHAIN LINKER DOMAIN-CONTAINING PROTEIN 1 clathrin binding#GO:0030276;binding#GO:0005488;protein binding#GO:0005515 cellular process#GO:0009987;endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;transport#GO:0006810;localization#GO:0051179;import into cell#GO:0098657;establishment of localization#GO:0051234;receptor-mediated endocytosis#GO:0006898 membrane#GO:0016020;membrane protein complex#GO:0098796;clathrin coat#GO:0030118;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;membrane coat#GO:0030117;coated membrane#GO:0048475;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150;vesicle coat protein#PC00235 HUMAN|HGNC=25601|UniProtKB=Q9HAD4 Q9HAD4 WDR41 PTHR22805:SF2 WDR41-RELATED WD REPEAT-CONTAINING PROTEIN 41 HUMAN|HGNC=25748|UniProtKB=Q96GJ1 Q96GJ1 TRMT2B PTHR45904:SF1 TRNA (URACIL-5-)-METHYLTRANSFERASE TRNA (URACIL-5-)-METHYLTRANSFERASE HOMOLOG B RNA methyltransferase#PC00033 HUMAN|HGNC=11796|UniProtKB=P10827 P10827 THRA PTHR24082:SF42 NUCLEAR HORMONE RECEPTOR THYROID HORMONE RECEPTOR ALPHA transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;molecular transducer activity#GO:0060089;nuclear receptor activity#GO:0004879;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;sequence-specific double-stranded DNA binding#GO:1990837 positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;nuclear receptor-mediated signaling pathway#GO:0141193;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;intracellular receptor signaling pathway#GO:0030522;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;negative regulation of transcription by RNA polymerase II#GO:0000122;intracellular signal transduction#GO:0035556;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;cell communication#GO:0007154;regulation of DNA-templated transcription#GO:0006355;positive regulation of macromolecule metabolic process#GO:0010604;response to chemical#GO:0042221;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;response to hormone#GO:0009725;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;positive regulation of transcription by RNA polymerase II#GO:0045944;signaling#GO:0023052;negative regulation of metabolic process#GO:0009892;cellular response to endogenous stimulus#GO:0071495;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;cellular response to hormone stimulus#GO:0032870;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;response to endogenous stimulus#GO:0009719;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;hormone-mediated signaling pathway#GO:0009755;negative regulation of DNA-templated transcription#GO:0045892;cellular response to chemical stimulus#GO:0070887 transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575 C4 zinc finger nuclear receptor#PC00169 HUMAN|HGNC=32416|UniProtKB=A6NKT7 A6NKT7 RGPD3 PTHR23138:SF168 RAN BINDING PROTEIN RANBP2-LIKE AND GRIP DOMAIN-CONTAINING PROTEIN 1-RELATED aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;SUMO transferase activity#GO:0019789;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740 nuclear transport#GO:0051169;nuclear export#GO:0051168;protein import into nucleus#GO:0006606;protein transport#GO:0015031;NLS-bearing protein import into nucleus#GO:0006607;localization#GO:0051179;cellular localization#GO:0051641;nucleocytoplasmic transport#GO:0006913;protein localization to organelle#GO:0033365;intracellular protein localization#GO:0008104;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule localization#GO:0033036;import into nucleus#GO:0051170;protein localization to nucleus#GO:0034504 nucleus#GO:0005634;organelle envelope#GO:0031967;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear pore#GO:0005643;nuclear protein-containing complex#GO:0140513 scaffold/adaptor protein#PC00226 HUMAN|HGNC=21617|UniProtKB=Q8N3L3 Q8N3L3 TXLNB PTHR16127:SF10 TAXILIN BETA-TAXILIN membrane traffic protein#PC00150 HUMAN|HGNC=11302|UniProtKB=Q9UHB9 Q9UHB9 SRP68 PTHR12860:SF0 SIGNAL RECOGNITION PARTICLE 68 KDA PROTEIN SIGNAL RECOGNITION PARTICLE SUBUNIT SRP68 ribonucleoprotein complex binding#GO:0043021;protein-containing complex binding#GO:0044877;binding#GO:0005488 establishment of protein localization#GO:0045184;cellular process#GO:0009987;establishment of protein localization to membrane#GO:0090150;establishment of protein localization to endoplasmic reticulum#GO:0072599;protein targeting#GO:0006605;localization within membrane#GO:0051668;SRP-dependent cotranslational protein targeting to membrane#GO:0006614;protein targeting to membrane#GO:0006612;protein targeting to ER#GO:0045047;establishment of protein localization to organelle#GO:0072594;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;signal recognition particle, endoplasmic reticulum targeting#GO:0005786;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 RNA metabolism protein#PC00031 HUMAN|HGNC=3712|UniProtKB=P68106 P68106 FKBP1B PTHR10516:SF429 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP1B catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;peptidyl-prolyl cis-trans isomerase activity#GO:0003755;isomerase activity#GO:0016853;cis-trans isomerase activity#GO:0016859 regulation of metal ion transport#GO:0010959;regulation of cellular process#GO:0050794;regulation of heart contraction#GO:0008016;primary metabolic process#GO:0044238;regulation of transmembrane transport#GO:0034762;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;protein metabolic process#GO:0019538;intracellular signal transduction#GO:0035556;regulation of monoatomic ion transport#GO:0043269;regulation of calcium ion transport#GO:0051924;biological regulation#GO:0065007;biosynthetic process#GO:0009058;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;calcium-mediated signaling#GO:0019722;regulation of monoatomic cation transmembrane transport#GO:1904062;regulation of system process#GO:0044057;response to stimulus#GO:0050896;signaling#GO:0023052;protein folding#GO:0006457;regulation of muscle system process#GO:0090257;regulation of biological process#GO:0050789;regulation of muscle contraction#GO:0006937;gene expression#GO:0010467;protein maturation#GO:0051604;regulation of multicellular organismal process#GO:0051239;intracellular signaling cassette#GO:0141124;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of monoatomic ion transmembrane transport#GO:0034765;regulation of transport#GO:0051049;regulation of localization#GO:0032879;regulation of release of sequestered calcium ion into cytosol#GO:0051279;metabolic process#GO:0008152 intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;sarcoplasm#GO:0016528;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;sarcoplasmic reticulum#GO:0016529;membrane#GO:0016020;cytoplasm#GO:0005737;sarcoplasmic reticulum membrane#GO:0033017;endomembrane system#GO:0012505 chaperone#PC00072 TGF-beta signaling pathway#P00052>FKBP12#P01288 HUMAN|Gene=YM012_HUMAN|UniProtKB=Q9UF83 Q9UF83 PTHR35683:SF7 YALI0C04136P APPLE DOMAIN-CONTAINING PROTEIN HUMAN|HGNC=3749|UniProtKB=Q01543 Q01543 FLI1 PTHR11849:SF161 ETS FRIEND LEUKEMIA INTEGRATION 1 TRANSCRIPTION FACTOR DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110 regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;developmental process#GO:0032502;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 winged helix/forkhead transcription factor#PC00246;DNA-binding transcription factor#PC00218 PDGF signaling pathway#P00047>Ets#P01167 HUMAN|HGNC=18518|UniProtKB=O75792 O75792 RNASEH2A PTHR10954:SF7 RIBONUCLEASE H2 SUBUNIT A RIBONUCLEASE H2 SUBUNIT A hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;RNA nuclease activity#GO:0004540;endonuclease activity#GO:0004519;RNA endonuclease activity#GO:0004521;catalytic activity, acting on RNA#GO:0140098;nuclease activity#GO:0004518;hydrolase activity#GO:0016787 DNA-templated DNA replication#GO:0006261;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;DNA replication#GO:0006260;cellular response to stimulus#GO:0051716;mismatch repair#GO:0006298;macromolecule metabolic process#GO:0043170;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;DNA damage response#GO:0006974;nucleobase-containing compound metabolic process#GO:0006139;response to stress#GO:0006950;cellular process#GO:0009987 catalytic complex#GO:1902494;protein-containing complex#GO:0032991;intracellular protein-containing complex#GO:0140535 endoribonuclease#PC00094 DNA replication#P00017>RNase H#P00538 HUMAN|HGNC=6459|UniProtKB=Q9NSB4 Q9NSB4 KRT82 PTHR45616:SF12 GATA-TYPE DOMAIN-CONTAINING PROTEIN KERATIN, TYPE II CUTICULAR HB2 structural molecule activity#GO:0005198 developmental process#GO:0032502;epidermis development#GO:0008544;animal organ development#GO:0048513;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;skin development#GO:0043588;epidermal cell differentiation#GO:0009913;multicellular organismal process#GO:0032501;epithelial cell differentiation#GO:0030855;tissue development#GO:0009888;epithelium development#GO:0060429;intermediate filament organization#GO:0045109;animal gross anatomical part developmental process#GO:0160108;keratinocyte differentiation#GO:0030216;intermediate filament-based process#GO:0045103;supramolecular fiber organization#GO:0097435;anatomical structure development#GO:0048856;cellular component organization#GO:0016043;cell differentiation#GO:0030154;intermediate filament cytoskeleton organization#GO:0045104 organelle#GO:0043226;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;intermediate filament#GO:0005882;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 HUMAN|HGNC=17286|UniProtKB=Q9Y3B2 Q9Y3B2 EXOSC1 PTHR12686:SF8 3'-5' EXORIBONUCLEASE CSL4-RELATED EXOSOME COMPLEX COMPONENT CSL4 rRNA processing#GO:0006364;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;RNA biosynthetic process#GO:0032774;rRNA metabolic process#GO:0016072;negative regulation of cellular process#GO:0048523;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;nucleobase-containing compound catabolic process#GO:0034655;nucleic acid catabolic process#GO:0141188;macromolecule biosynthetic process#GO:0009059;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;negative regulation of biosynthetic process#GO:0009890;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA catabolic process#GO:0006401;RNA metabolic process#GO:0016070;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;regulation of biological process#GO:0050789;ribonucleoprotein complex biogenesis#GO:0022613;mRNA metabolic process#GO:0016071;maturation of 5.8S rRNA#GO:0000460;negative regulation of metabolic process#GO:0009892;macromolecule catabolic process#GO:0009057;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;RNA 3'-end processing#GO:0031123;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;mRNA catabolic process#GO:0006402;cellular process#GO:0009987;gene expression#GO:0010467;RNA processing#GO:0006396 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;protein-containing complex#GO:0032991;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 exoribonuclease#PC00099;RNA metabolism protein#PC00031 HUMAN|HGNC=8234|UniProtKB=Q96R45 Q96R45 OR2A7 PTHR26451:SF971 G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN OLFACTORY RECEPTOR 2A4-RELATED olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;response to stimulus#GO:0050896;response to chemical#GO:0042221;detection of chemical stimulus#GO:0009593;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;system process#GO:0003008;nervous system process#GO:0050877;sensory perception#GO:0007600;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907 cellular anatomical structure#GO:0110165;membrane#GO:0016020 G-protein coupled receptor#PC00021 HUMAN|HGNC=28014|UniProtKB=A1A4G5 A1A4G5 LNP1 PTHR35667:SF1 LEUKEMIA NUP98 FUSION PARTNER 1 LEUKEMIA NUP98 FUSION PARTNER 1 HUMAN|HGNC=6819|UniProtKB=Q9UDY8 Q9UDY8 MALT1 PTHR22576:SF40 MUCOSA ASSOCIATED LYMPHOID TISSUE LYMPHOMA TRANSLOCATION PROTEIN 1/PARACASPASE MUCOSA-ASSOCIATED LYMPHOID TISSUE LYMPHOMA TRANSLOCATION PROTEIN 1 catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity#GO:0003824 signal transduction#GO:0007165;defense response to symbiont#GO:0140546;activation of immune response#GO:0002253;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;response to biotic stimulus#GO:0009607;positive regulation of immune system process#GO:0002684;response to stress#GO:0006950;antigen receptor-mediated signaling pathway#GO:0050851;lymphocyte activation#GO:0046649;defense response to other organism#GO:0098542;cell surface receptor signaling pathway#GO:0007166;B cell activation#GO:0042113;immune response-activating signaling pathway#GO:0002757;positive regulation of canonical NF-kappaB signal transduction#GO:0043123;regulation of biological process#GO:0050789;immune response-regulating signaling pathway#GO:0002764;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;regulation of signaling#GO:0023051;immune system process#GO:0002376;regulation of intracellular signal transduction#GO:1902531;positive regulation of signaling#GO:0023056;immune response#GO:0006955;positive regulation of cellular process#GO:0048522;regulation of canonical NF-kappaB signal transduction#GO:0043122;immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;response to other organism#GO:0051707;positive regulation of response to stimulus#GO:0048584;multicellular organismal process#GO:0032501;positive regulation of immune response#GO:0050778;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;T cell receptor signaling pathway#GO:0050852;response to external stimulus#GO:0009605;defense response#GO:0006952;innate immune response#GO:0045087;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;leukocyte activation#GO:0045321;response to external biotic stimulus#GO:0043207;immune response-activating cell surface receptor signaling pathway#GO:0002429;regulation of cell communication#GO:0010646;regulation of immune system process#GO:0002682;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of immune response#GO:0050776;cell activation#GO:0001775;cell communication#GO:0007154 cysteine protease#PC00081;protease#PC00190 HUMAN|HGNC=11853|UniProtKB=P30408 P30408 TM4SF1 PTHR14198:SF18 TRANSMEMBRANE 4 L6 FAMILY MEMBER 1-RELATED TRANSMEMBRANE 4 L6 FAMILY MEMBER 1 cellular anatomical structure#GO:0110165;membrane#GO:0016020 HUMAN|HGNC=11541|UniProtKB=Q15545 Q15545 TAF7 PTHR12228:SF6 TRANSCRIPTION INITIATION FACTOR TFIID 55 KD SUBUNIT-RELATED TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 7 nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;protein-containing complex assembly#GO:0065003;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;regulation of transcription by RNA polymerase II#GO:0006357;DNA-templated transcription initiation#GO:0006352;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;protein-containing complex organization#GO:0043933;protein-DNA complex organization#GO:0071824;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;transcription initiation at RNA polymerase II promoter#GO:0006367;cellular component biogenesis#GO:0044085;protein-DNA complex assembly#GO:0065004;cellular component assembly#GO:0022607;gene expression#GO:0010467;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;RNA polymerase II preinitiation complex assembly#GO:0051123;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;transcription by RNA polymerase II#GO:0006366;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;macromolecule biosynthetic process#GO:0009059;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;regulation of nucleobase-containing compound metabolic process#GO:0019219 RNA polymerase II transcription regulator complex#GO:0090575;membrane-enclosed lumen#GO:0031974;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;protein-containing complex#GO:0032991;transcription factor TFIID complex#GO:0005669;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;transcription regulator complex#GO:0005667;intracellular protein-containing complex#GO:0140535;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;RNA polymerase II, holoenzyme#GO:0016591;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428 general transcription factor#PC00259 Transcription regulation by bZIP transcription factor#P00055>TBP-associated factors#P01385;General transcription regulation#P00023>TBP-associated factors#P00658 HUMAN|HGNC=23091|UniProtKB=Q8WWX8 Q8WWX8 SLC5A11 PTHR11819:SF171 SOLUTE CARRIER FAMILY 5 SODIUM_MYO-INOSITOL COTRANSPORTER 2 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227;secondary carrier transporter#PC00258 HUMAN|HGNC=20450|UniProtKB=Q3C1V8 Q3C1V8 BSX PTHR24327:SF35 HOMEOBOX PROTEIN BRAIN-SPECIFIC HOMEOBOX PROTEIN HOMOLOG transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 feeding behavior#GO:0007631;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;developmental process#GO:0032502;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;stem cell population maintenance#GO:0019827;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;cellular process#GO:0009987;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;maintenance of cell number#GO:0098727 gene-specific transcriptional regulator#PC00264;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=19066|UniProtKB=Q9Y330 Q9Y330 ZBTB12 PTHR24399:SF38 ZINC FINGER AND BTB DOMAIN-CONTAINING ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 12 sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription repressor activity#GO:0001217;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488 regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;negative regulation of metabolic process#GO:0009892;negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of cytokine production#GO:0001817;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of multicellular organismal process#GO:0051239;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007 intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218 HUMAN|HGNC=6273|UniProtKB=P57789 P57789 KCNK10 PTHR11003:SF32 POTASSIUM CHANNEL, SUBFAMILY K POTASSIUM CHANNEL SUBFAMILY K MEMBER 10 transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261;outward rectifier potassium channel activity#GO:0015271;potassium channel activity#GO:0005267;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079 monoatomic cation transport#GO:0006812;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;transport#GO:0006810;potassium ion transport#GO:0006813;metal ion transport#GO:0030001;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HUMAN|HGNC=17705|UniProtKB=O60613 O60613 SELENOF PTHR13077:SF6 SELENOPROTEIN F SELENOPROTEIN F oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;endoplasmic reticulum lumen#GO:0005788;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 HUMAN|HGNC=25566|UniProtKB=Q9C0A6 Q9C0A6 SETD5 PTHR46462:SF1 UPSET, ISOFORM A HISTONE-LYSINE N-METHYLTRANSFERASE SETD5 regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 Rpd3L-Expanded complex#GO:0070210;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;chromosome#GO:0005694;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;protein-containing complex#GO:0032991;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;histone deacetylase complex#GO:0000118;membrane-enclosed lumen#GO:0031974;chromatin#GO:0000785;nucleus#GO:0005634 HUMAN|HGNC=32949|UniProtKB=Q9NXE4 Q9NXE4 SMPD4 PTHR12988:SF6 SPHINGOMYELIN PHOSPHODIESTERASE 4 SPHINGOMYELIN PHOSPHODIESTERASE 4 hydrolase activity#GO:0016787;phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578;lipase activity#GO:0016298;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phospholipase activity#GO:0120569 glycerolipid catabolic process#GO:0046503;organophosphate catabolic process#GO:0046434;ceramide metabolic process#GO:0006672;sphingolipid catabolic process#GO:0030149;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;glycerolipid metabolic process#GO:0046486;catabolic process#GO:0009056;phospholipid catabolic process#GO:0009395;phospholipid metabolic process#GO:0006644;metabolic process#GO:0008152;sphingolipid metabolic process#GO:0006665;sphingolipid biosynthetic process#GO:0030148;ceramide biosynthetic process#GO:0046513;lipid metabolic process#GO:0006629;glycerophospholipid catabolic process#GO:0046475;organophosphate metabolic process#GO:0019637;lipid catabolic process#GO:0016042;cellular process#GO:0009987;glycerophospholipid metabolic process#GO:0006650;sphingomyelin metabolic process#GO:0006684;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058 phosphodiesterase#PC00185 HUMAN|HGNC=2277|UniProtKB=P12074 P12074 COX6A1 PTHR11504:SF11 CYTOCHROME C OXIDASE POLYPEPTIDE VIA CYTOCHROME C OXIDASE SUBUNIT 6A1, MITOCHONDRIAL enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 aerobic respiration#GO:0009060;cellular respiration#GO:0045333;energy derivation by oxidation of organic compounds#GO:0015980;oxidative phosphorylation#GO:0006119;ATP synthesis coupled electron transport#GO:0042773;generation of precursor metabolites and energy#GO:0006091;mitochondrial electron transport, cytochrome c to oxygen#GO:0006123;aerobic electron transport chain#GO:0019646;metabolic process#GO:0008152;respiratory electron transport chain#GO:0022904;cellular process#GO:0009987;mitochondrial ATP synthesis coupled electron transport#GO:0042775;electron transport chain#GO:0022900 transmembrane transporter complex#GO:1902495;respiratory chain complex IV#GO:0045277;transporter complex#GO:1990351;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;respiratory chain complex#GO:0098803;cytochrome complex#GO:0070069;membrane protein complex#GO:0098796;membrane#GO:0016020;oxidoreductase complex#GO:1990204 oxidase#PC00175 HUMAN|HGNC=14374|UniProtKB=Q9C000 Q9C000 NLRP1 PTHR46985:SF3 NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 molecular function activator activity#GO:0140677;pattern recognition receptor activity#GO:0038187;enzyme regulator activity#GO:0030234;molecular transducer activity#GO:0060089;peptidase regulator activity#GO:0061134;endopeptidase regulator activity#GO:0061135;signaling receptor activity#GO:0038023;molecular function regulator activity#GO:0098772;peptidase activator activity#GO:0016504;enzyme activator activity#GO:0008047 regulation of response to biotic stimulus#GO:0002831;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;cell death#GO:0008219;cellular response to stimulus#GO:0051716;programmed cell death#GO:0012501;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;regulation of immune response#GO:0050776;inflammatory response#GO:0006954;regulation of defense response#GO:0031347;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;positive regulation of innate immune response#GO:0045089;activation of innate immune response#GO:0002218;positive regulation of response to biotic stimulus#GO:0002833;defense response#GO:0006952;regulation of innate immune response#GO:0045088;apoptotic signaling pathway#GO:0097190;positive regulation of defense response#GO:0031349;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;regulation of response to stress#GO:0080134;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;apoptotic process#GO:0006915;intrinsic apoptotic signaling pathway#GO:0097193;immune system process#GO:0002376;regulation of response to external stimulus#GO:0032101;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;signal transduction#GO:0007165;cellular process#GO:0009987;response to stress#GO:0006950;positive regulation of immune system process#GO:0002684;positive regulation of response to external stimulus#GO:0032103 intracellular organelle#GO:0043229;canonical inflammasome complex#GO:0061702;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 defense/immunity protein#PC00090 HUMAN|HGNC=17826|UniProtKB=Q86VZ2 Q86VZ2 WDR5B PTHR22847:SF516 WD40 REPEAT PROTEIN WD REPEAT-CONTAINING PROTEIN 5B histone reader activity#GO:0140566;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;chromatin-protein adaptor activity#GO:0140463 positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;transcription by RNA polymerase II#GO:0006366;regulation of nucleobase-containing compound metabolic process#GO:0019219;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;regulation of RNA biosynthetic process#GO:2001141;chromatin organization#GO:0006325;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of cellular process#GO:0048522;macromolecule biosynthetic process#GO:0009059;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;regulation of transcription by RNA polymerase II#GO:0006357;DNA-templated transcription initiation#GO:0006352;chromatin remodeling#GO:0006338;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;transcription initiation-coupled chromatin remodeling#GO:0045815;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;positive regulation of macromolecule metabolic process#GO:0010604;gene expression#GO:0010467;transcription initiation at RNA polymerase II promoter#GO:0006367;positive regulation of biological process#GO:0048518;cellular process#GO:0009987 nucleus#GO:0005634;chromatin#GO:0000785;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;H4 histone acetyltransferase complex#GO:1902562;transferase complex#GO:1990234;histone methyltransferase complex#GO:0035097;histone acetyltransferase complex#GO:0000123;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;Set1C/COMPASS complex#GO:0048188;chromosome#GO:0005694;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;methyltransferase complex#GO:0034708;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;protein acetyltransferase complex#GO:0031248;intracellular organelle lumen#GO:0070013;acetyltransferase complex#GO:1902493;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;NSL complex#GO:0044545 HUMAN|HGNC=12576|UniProtKB=Q16831 Q16831 UPP1 PTHR43691:SF10 URIDINE PHOSPHORYLASE URIDINE PHOSPHORYLASE 1 catalytic activity#GO:0003824;transferase activity#GO:0016740;pentosyltransferase activity#GO:0016763;glycosyltransferase activity#GO:0016757 pyrimidine-containing compound metabolic process#GO:0072527;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;glycosyl compound catabolic process#GO:1901658;nucleobase-containing compound catabolic process#GO:0034655;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;primary metabolic process#GO:0044238;nucleobase-containing small molecule catabolic process#GO:0034656;carbohydrate derivative catabolic process#GO:1901136;small molecule catabolic process#GO:0044282;nucleoside metabolic process#GO:0009116;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;nucleoside catabolic process#GO:0009164 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 nucleotide kinase#PC00172;metabolite interconversion enzyme#PC00262 Salvage pyrimidine ribonucleotides#P02775>Uridine phosphorylase#P03152 HUMAN|HGNC=5276|UniProtKB=O43719 O43719 HTATSF1 PTHR15608:SF0 SPLICING FACTOR U2AF-ASSOCIATED PROTEIN 2 17S U2 SNRNP COMPLEX COMPONENT HTATSF1 nucleic acid binding#GO:0003676;binding#GO:0005488;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;chromatin-protein adaptor activity#GO:0140463;RNA binding#GO:0003723 RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;protein-containing complex organization#GO:0043933;protein-RNA complex organization#GO:0071826;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;mRNA processing#GO:0006397;cellular component biogenesis#GO:0044085;RNA processing#GO:0006396;gene expression#GO:0010467;cellular component assembly#GO:0022607;spliceosomal complex assembly#GO:0000245;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;mRNA splicing, via spliceosome#GO:0000398;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;ribonucleoprotein complex biogenesis#GO:0022613;mRNA metabolic process#GO:0016071;intracellular protein localization#GO:0008104;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;macromolecule localization#GO:0033036;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA splicing, via transesterification reactions#GO:0000375;protein-RNA complex assembly#GO:0022618;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;localization#GO:0051179;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;protein localization to organelle#GO:0033365 U2 snRNP#GO:0005686;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;Sm-like protein family complex#GO:0120114;nucleus#GO:0005634;small nuclear ribonucleoprotein complex#GO:0030532;site of double-strand break#GO:0035861;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;membrane-bounded organelle#GO:0043227;site of DNA damage#GO:0090734;intracellular anatomical structure#GO:0005622;spliceosomal snRNP complex#GO:0097525;spliceosomal complex#GO:0005681;chromosome#GO:0005694;U2-type spliceosomal complex#GO:0005684;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 RNA processing factor#PC00147;RNA splicing factor#PC00148 HUMAN|HGNC=25063|UniProtKB=Q6E0U4 Q6E0U4 DMKN PTHR36881:SF1 DERMOKINE DERMOKINE cellular component organization or biogenesis#GO:0071840;plasma membrane organization#GO:0007009;membrane organization#GO:0061024;endomembrane system organization#GO:0010256;cellular component assembly#GO:0022607;cellular process#GO:0009987;membrane assembly#GO:0071709;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=713|UniProtKB=P15289 P15289 ARSA PTHR42693:SF11 ARYLSULFATASE FAMILY MEMBER ARYLSULFATASE A catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787 hydrolase#PC00121 HUMAN|HGNC=15573|UniProtKB=Q9Y6X0 Q9Y6X0 SETBP1 PTHR46147:SF2 HISTONE-LYSINE N-METHYLTRANSFERASE ASH1 SET-BINDING PROTEIN transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein methyltransferase activity#GO:0008276;catalytic activity, acting on a protein#GO:0140096;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;N-methyltransferase activity#GO:0008170;protein-lysine N-methyltransferase activity#GO:0016279;histone methyltransferase activity#GO:0042054;histone modifying activity#GO:0140993;histone H3 methyltransferase activity#GO:0140938;lysine N-methyltransferase activity#GO:0016278;histone H3K4 methyltransferase activity#GO:0042800 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233 histone modifying enzyme#PC00261;chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=29524|UniProtKB=Q8N4E4 Q8N4E4 PDCL2 PTHR45809:SF1 VIRAL IAP-ASSOCIATED FACTOR HOMOLOG PHOSDUCIN-LIKE PROTEIN 2 biosynthetic process#GO:0009058;protein folding#GO:0006457;protein maturation#GO:0051604;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 viral or transposable element protein#PC00237 HUMAN|HGNC=39025|UniProtKB=Q9QC07 Q9QC07 ERVK-18 PTHR41694:SF3 ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN ENDOGENOUS RETROVIRUS GROUP K MEMBER 10 POL PROTEIN-RELATED RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 viral or transposable element protein#PC00237 HUMAN|HGNC=930|UniProtKB=Q9UBV7 Q9UBV7 B4GALT7 PTHR19300:SF30 BETA-1,4-GALACTOSYLTRANSFERASE BETA-1,4-GALACTOSYLTRANSFERASE 7 galactosyltransferase activity#GO:0008378;glycosyltransferase activity#GO:0016757;hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111;metabolite interconversion enzyme#PC00262 Wnt signaling pathway#P00057>Calcineurin#P01446 HUMAN|HGNC=17118|UniProtKB=Q9H0A6 Q9H0A6 RNF32 PTHR14991:SF0 RING FINGER PROTEIN 32 RING FINGER PROTEIN 32 HUMAN|HGNC=6062|UniProtKB=Q9UK53 Q9UK53 ING1 PTHR10333:SF85 INHIBITOR OF GROWTH PROTEIN INHIBITOR OF GROWTH PROTEIN 1 chromatin-protein adaptor activity#GO:0140463;protein-macromolecule adaptor activity#GO:0030674;histone H3 reader activity#GO:0140006;molecular adaptor activity#GO:0060090;histone reader activity#GO:0140566 regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;chromatin organization#GO:0006325;regulation of RNA biosynthetic process#GO:2001141;regulation of DNA-templated transcription#GO:0006355;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;Sin3-type complex#GO:0070822;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;chromosome#GO:0005694;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;histone deacetylase complex#GO:0000118;membrane-enclosed lumen#GO:0031974;chromatin#GO:0000785;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=20453|UniProtKB=Q9H2R5 Q9H2R5 KLK15 PTHR24271:SF60 KALLIKREIN-RELATED KALLIKREIN-15 serine-type peptidase activity#GO:0008236;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096 metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604 vesicle#GO:0031982;intracellular vesicle#GO:0097708;secretory vesicle#GO:0099503;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;extracellular region#GO:0005576;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622 serine protease#PC00203 HUMAN|HGNC=2455|UniProtKB=P78368 P78368 CSNK1G2 PTHR11909:SF157 CASEIN KINASE-RELATED CASEIN KINASE I ISOFORM GAMMA-2 catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 signal transduction#GO:0007165;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of canonical Wnt signaling pathway#GO:0060828;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;positive regulation of Wnt signaling pathway#GO:0030177;regulation of response to stimulus#GO:0048583;positive regulation of canonical Wnt signaling pathway#GO:0090263;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;signaling#GO:0023052;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of signaling#GO:0023051;cell communication#GO:0007154;positive regulation of signaling#GO:0023056 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cell periphery#GO:0071944;nucleus#GO:0005634;membrane#GO:0016020 non-receptor serine/threonine protein kinase#PC00167 Wnt signaling pathway#P00057>Casein Kinase 1#P01460;Parkinson disease#P00049>Casein kinase I#P01242 HUMAN|HGNC=23693|UniProtKB=Q9UJ42 Q9UJ42 GPR160 PTHR15573:SF0 G-PROTEIN COUPLED RECEPTOR 160-RELATED G PROTEIN-COUPLED RECEPTOR 160-RELATED cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;signaling receptor complex#GO:0043235 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=25768|UniProtKB=Q96BU1 Q96BU1 S100PBP PTHR14455:SF0 ASKOPOS S100P-BINDING PROTEIN HUMAN|HGNC=12608|UniProtKB=Q14694 Q14694 USP10 PTHR24006:SF947 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 10 catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;cysteine-type deubiquitinase activity#GO:0004843;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787 regulation of biological quality#GO:0065008;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;cellular response to stress#GO:0033554;signal transduction by p53 class mediator#GO:0072331;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction in response to DNA damage#GO:0042770;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;regulation of autophagy#GO:0010506;regulation of catabolic process#GO:0009894;DNA damage response#GO:0006974;biological regulation#GO:0065007;regulation of protein stability#GO:0031647;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of metabolic process#GO:0019222;response to stress#GO:0006950 intracellular vesicle#GO:0097708;cytosol#GO:0005829;nucleus#GO:0005634;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;early endosome#GO:0005769 cysteine protease#PC00081;protease#PC00190 HUMAN|HGNC=5870|UniProtKB=P15814 P15814 IGLL1 PTHR23266:SF419 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN LAMBDA-LIKE POLYPEPTIDE 1 binding#GO:0005488;antigen binding#GO:0003823 response to stimulus#GO:0050896;adaptive immune response#GO:0002250;immune response#GO:0006955;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;immunoglobulin mediated immune response#GO:0016064;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immune system process#GO:0002376;immune effector process#GO:0002252 protein-containing complex#GO:0032991 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=23574|UniProtKB=Q504Y3 Q504Y3 ZCWPW2 PTHR15999:SF6 ZINC FINGER CW-TYPE PWWP DOMAIN PROTEIN 1 ZINC FINGER CW-TYPE PWWP DOMAIN PROTEIN 2 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=4881|UniProtKB=Q9UBP5 Q9UBP5 HEY2 PTHR10985:SF88 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED HAIRY_ENHANCER-OF-SPLIT RELATED WITH YRPW MOTIF PROTEIN 2 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of gene expression#GO:0010468;Notch signaling pathway#GO:0007219;regulation of biosynthetic process#GO:0009889;regulation of cell differentiation#GO:0045595;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;multicellular organismal process#GO:0032501;regionalization#GO:0003002;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cell development#GO:0060284;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of nervous system development#GO:0051960;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;cell communication#GO:0007154;pattern specification process#GO:0007389;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;cellular response to stimulus#GO:0051716;regulation of neurogenesis#GO:0050767;multicellular organism development#GO:0007275;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;cell surface receptor signaling pathway#GO:0007166;anterior/posterior pattern specification#GO:0009952;regulation of multicellular organismal process#GO:0051239;cellular process#GO:0009987;signal transduction#GO:0007165;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;animal gross anatomical part developmental process#GO:0160108;signaling#GO:0023052;negative regulation of metabolic process#GO:0009892;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;circulatory system development#GO:0072359;regulation of multicellular organismal development#GO:2000026;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 basic helix-loop-helix transcription factor#PC00055 Notch signaling pathway#P00045>E(spl)-C genes#G01541 HUMAN|HGNC=14432|UniProtKB=Q96Q45 Q96Q45 TMEM237 PTHR28388:SF1 TRANSMEMBRANE PROTEIN 237 TRANSMEMBRANE PROTEIN 237 cilium organization#GO:0044782;cellular component organization or biogenesis#GO:0071840;organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031;plasma membrane bounded cell projection organization#GO:0120036;cell projection organization#GO:0030030;cellular component assembly#GO:0022607;cell projection assembly#GO:0030031;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;cilium assembly#GO:0060271 ciliary transition zone#GO:0035869;cilium#GO:0005929;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995 HUMAN|HGNC=12504|UniProtKB=O95164 O95164 UBL3 PTHR13169:SF0 UBIQUITIN-LIKE PROTEIN 3 HCG-1 PROTEIN UBIQUITIN-LIKE PROTEIN 3 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=32256|UniProtKB=A6NJQ4 A6NJQ4 FAM90A8 PTHR16035:SF14 PROTEIN FAM90A1 PROTEIN FAM90A10-RELATED HUMAN|HGNC=2905|UniProtKB=O14490 O14490 DLGAP1 PTHR12353:SF7 DISKS LARGE-ASSOCIATED PROTEIN DAP SAP90/PSD-95-ASSOCIATED PROTEIN DISKS LARGE-ASSOCIATED PROTEIN 1 regulation of signaling#GO:0023051;regulation of biological process#GO:0050789;regulation of cell communication#GO:0010646;biological regulation#GO:0065007;modulation of chemical synaptic transmission#GO:0050804;regulation of cellular process#GO:0050794;regulation of trans-synaptic signaling#GO:0099177 organelle#GO:0043226;cell junction#GO:0030054;postsynaptic specialization#GO:0099572;glutamatergic synapse#GO:0098978;synapse#GO:0045202;cellular anatomical structure#GO:0110165;postsynapse#GO:0098794 scaffold/adaptor protein#PC00226 HUMAN|HGNC=24165|UniProtKB=Q9BXX2 Q9BXX2 ANKRD30B PTHR24147:SF52 ANKYRIN REPEAT DOMAIN 36-RELATED ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 30B HUMAN|HGNC=25875|UniProtKB=Q9H7X0 Q9H7X0 NAA60 PTHR14744:SF15 N-ALPHA-ACETYLTRANSFERASE 60 N-ALPHA-ACETYLTRANSFERASE 60 transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity, acting on a protein#GO:0140096;protein N-acetyltransferase activity#GO:0034212;protein-N-terminal amino-acid acetyltransferase activity#GO:0004596;N-acetyltransferase activity#GO:0008080;acetyltransferase activity#GO:0016407;protein-lysine-acetyltransferase activity#GO:0061733;acyltransferase activity#GO:0016746;histone acetyltransferase activity#GO:0004402;histone modifying activity#GO:0140993;protein N-acyltransferase activity#GO:0140186 cell cycle process#GO:0022402;cellular process#GO:0009987;chromosome segregation#GO:0007059;cell cycle#GO:0007049 membrane#GO:0016020;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090 transferase#PC00220;acetyltransferase#PC00038 HUMAN|HGNC=19768|UniProtKB=Q96NS5 Q96NS5 ASB16 PTHR24118:SF72 POTE ANKYRIN DOMAIN ANKYRIN REPEAT AND SOCS BOX PROTEIN 16 enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498 catalytic complex#GO:1902494;transferase complex#GO:1990234;Cul5-RING ubiquitin ligase complex#GO:0031466;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461 membrane traffic protein#PC00150 HUMAN|HGNC=3660|UniProtKB=Q9UHY8 Q9UHY8 FEZ2 PTHR12394:SF11 ZYGIN FASCICULATION AND ELONGATION PROTEIN ZETA-2 neuron projection#GO:0043005;axon#GO:0030424;plasma membrane bounded cell projection#GO:0120025;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cell projection#GO:0042995;cellular anatomical structure#GO:0110165 HUMAN|HGNC=18631|UniProtKB=Q9P1V8 Q9P1V8 SAMD15 PTHR46829:SF1 STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 15 STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 15 enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;kinase activator activity#GO:0019209;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;protein kinase regulator activity#GO:0019887;enzyme activator activity#GO:0008047;protein serine/threonine kinase activator activity#GO:0043539;protein kinase activator activity#GO:0030295 cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 HUMAN|HGNC=25346|UniProtKB=Q5RHP9 Q5RHP9 ERICH3 PTHR23034:SF2 GLUTAMATE-RICH PROTEIN 3 GLUTAMATE-RICH PROTEIN 3 HUMAN|HGNC=1400|UniProtKB=Q9NY47 Q9NY47 CACNA2D2 PTHR10166:SF7 VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2_DELTA-2 monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;transporter activity#GO:0005215;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;monoatomic cation channel activity#GO:0005261;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;voltage-gated calcium channel activity#GO:0005245;channel activity#GO:0015267 cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;voltage-gated calcium channel complex#GO:0005891;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;calcium channel complex#GO:0034704;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cation channel complex#GO:0034703 transporter#PC00227;voltage-gated ion channel#PC00241 HUMAN|HGNC=2376|UniProtKB=O95402 O95402 MED26 PTHR15201:SF1 CRSP70 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 26 transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of gene expression#GO:0010468;positive regulation of gene expression#GO:0010628;regulation of biosynthetic process#GO:0009889;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;RNA polymerase II transcription regulator complex#GO:0090575;core mediator complex#GO:0070847;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;mediator complex#GO:0016592;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 transcription cofactor#PC00217 HUMAN|HGNC=26625|UniProtKB=Q6NUS8 Q6NUS8 UGT3A1 PTHR48043:SF112 EG:EG0003.4 PROTEIN-RELATED UDP-GLYCOSYLTRANSFERASE 3A1 hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740;glucuronosyltransferase activity#GO:0015020;glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194 endoplasmic reticulum#GO:0005783;transferase complex#GO:1990234;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;endoplasmic reticulum protein-containing complex#GO:0140534;membrane#GO:0016020;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175 HUMAN|HGNC=6728|UniProtKB=O94772 O94772 LY6H PTHR32217:SF5 LYMPHOCYTE ANTIGEN 6H LYMPHOCYTE ANTIGEN 6H molecular function regulator activity#GO:0098772;signaling receptor regulator activity#GO:0030545;neurotransmitter receptor regulator activity#GO:0099602;molecular function inhibitor activity#GO:0140678;signaling receptor inhibitor activity#GO:0030547;protein binding#GO:0005515;acetylcholine receptor regulator activity#GO:0030548;binding#GO:0005488;acetylcholine receptor inhibitor activity#GO:0030550;signaling receptor binding#GO:0005102 signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987;synaptic signaling#GO:0099536;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;response to chemical#GO:0042221;cellular response to nitrogen compound#GO:1901699;acetylcholine receptor signaling pathway#GO:0095500;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;response to oxygen-containing compound#GO:1901700;cellular response to chemical stimulus#GO:0070887;response to nitrogen compound#GO:1901698;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HUMAN|HGNC=6205|UniProtKB=P17275 P17275 JUNB PTHR11462:SF37 JUN TRANSCRIPTION FACTOR-RELATED TRANSCRIPTION FACTOR JUNB transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 response to hormone#GO:0009725;positive regulation of biological process#GO:0048518;response to chemical#GO:0042221;positive regulation of macromolecule metabolic process#GO:0010604;response to lipid#GO:0033993;positive regulation of transcription by RNA polymerase II#GO:0045944;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;regulation of cell cycle#GO:0051726;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;response to steroid hormone#GO:0048545;positive regulation of biosynthetic process#GO:0009891;regulation of cell population proliferation#GO:0042127;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667 basic leucine zipper transcription factor#PC00056;DNA-binding transcription factor#PC00218 Gonadotropin-releasing hormone receptor pathway#P06664>JUN#P06757;TGF-beta signaling pathway#P00052>Co-activators corepressors#P01282;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>AP-1#P00838 HUMAN|HGNC=6886|UniProtKB=P45984 P45984 MAPK9 PTHR24055:SF172 MITOGEN-ACTIVATED PROTEIN KINASE MITOGEN-ACTIVATED PROTEIN KINASE 9 protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;JNK cascade#GO:0007254;biological regulation#GO:0065007;signaling#GO:0023052;intracellular signaling cassette#GO:0141124;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;MAPK cascade#GO:0000165;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 B cell activation#P00010>Jnk#P00402;Ras Pathway#P04393>JNK#P04572;Alzheimer disease-amyloid secretase pathway#P00003>MAPK#P00099;Huntington disease#P00029>JNK-2#P00799;Interferon-gamma signaling pathway#P00035>Serine kinase#P00955;FAS signaling pathway#P00020>JNK#P00615;EGF receptor signaling pathway#P00018>JNK1-3#P00545;Integrin signalling pathway#P00034>Jnk#P00951;FGF signaling pathway#P00021>JNK1-3#P00628;TGF-beta signaling pathway#P00052>JNK#P01284;T cell activation#P00053>Jnk#P01336;Parkinson disease#P00049>SAPK#P01219;Toll receptor signaling pathway#P00054>JNK#P01375;Oxidative stress response#P00046>JNK1/2#P01129;Apoptosis signaling pathway#P00006>JNK#P00274;CCKR signaling map#P06959>MAPK8-10#P07090;Gonadotropin-releasing hormone receptor pathway#P06664>JNK1/2#P06847 HUMAN|HGNC=10534|UniProtKB=Q9NR31 Q9NR31 SAR1A PTHR45684:SF6 RE74312P SMALL COPII COAT GTPASE SAR1A ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824 cellular process#GO:0009987;establishment of localization in cell#GO:0051649;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;membrane organization#GO:0061024;vesicle-mediated transport#GO:0016192;cellular component assembly#GO:0022607;transport#GO:0006810;Golgi vesicle transport#GO:0048193;intracellular transport#GO:0046907;protein-containing complex organization#GO:0043933;vesicle budding from membrane#GO:0006900;vesicle organization#GO:0016050;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;COPII-coated vesicle budding#GO:0090114;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;localization#GO:0051179 vesicle membrane#GO:0012506;membrane#GO:0016020;vesicle coat#GO:0030120;cytoplasm#GO:0005737;transport vesicle#GO:0030133;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;transport vesicle membrane#GO:0030658;ER to Golgi transport vesicle membrane#GO:0012507;endoplasmic reticulum#GO:0005783;endoplasmic reticulum exit site#GO:0070971;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;vesicle#GO:0031982;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;coated vesicle membrane#GO:0030662;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;coated vesicle#GO:0030135;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;coated membrane#GO:0048475;COPII-coated ER to Golgi transport vesicle#GO:0030134;membrane coat#GO:0030117 HUMAN|HGNC=1120|UniProtKB=Q9H0C5 Q9H0C5 BTBD1 PTHR45774:SF1 BTB/POZ DOMAIN-CONTAINING BTB_POZ DOMAIN-CONTAINING PROTEIN 1 multicellular organism development#GO:0007275;anatomical structure development#GO:0048856;cellular developmental process#GO:0048869;system development#GO:0048731;neurogenesis#GO:0022008;animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502;cell differentiation#GO:0030154;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;cellular process#GO:0009987 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=1656|UniProtKB=O95400 O95400 CD2BP2 PTHR13138:SF3 PROTEIN LIN1 CD2 ANTIGEN CYTOPLASMIC TAIL-BINDING PROTEIN 2 RNA metabolic process#GO:0016070;protein-RNA complex assembly#GO:0022618;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;spliceosomal snRNP assembly#GO:0000387;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;protein-containing complex assembly#GO:0065003;mRNA splicing, via spliceosome#GO:0000398;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-RNA complex organization#GO:0071826;protein-containing complex organization#GO:0043933;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;cellular component assembly#GO:0022607;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;mRNA processing#GO:0006397;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 nucleus#GO:0005634;small nuclear ribonucleoprotein complex#GO:0030532;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;spliceosomal snRNP complex#GO:0097525;U5 snRNP#GO:0005682;Sm-like protein family complex#GO:0120114 RNA processing factor#PC00147;RNA splicing factor#PC00148 HUMAN|HGNC=5817|UniProtKB=P01619 P01619 IGKV3-20 PTHR23267:SF472 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN KAPPA VARIABLE 3-20-RELATED response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 protein-containing complex#GO:0032991 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=29279|UniProtKB=Q9P281 Q9P281 BAHCC1 PTHR12505:SF22 PHD FINGER TRANSCRIPTION FACTOR BAH AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=3500|UniProtKB=P34910 P34910 EVI2B PTHR15384:SF0 PROTEIN EVI2B PROTEIN EVI2B regulation of hemopoiesis#GO:1903706;regulation of cell division#GO:0051302;regulation of myeloid cell differentiation#GO:0045637;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of developmental process#GO:0050793;regulation of multicellular organismal development#GO:2000026;positive regulation of multicellular organismal process#GO:0051240;regulation of biological process#GO:0050789;positive regulation of cell differentiation#GO:0045597;regulation of cell differentiation#GO:0045595;positive regulation of developmental process#GO:0051094;regulation of multicellular organismal process#GO:0051239;positive regulation of cell development#GO:0010720;biological regulation#GO:0065007;positive regulation of immune system process#GO:0002684;regulation of cell development#GO:0060284;positive regulation of myeloid cell differentiation#GO:0045639;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522 HUMAN|HGNC=5559|UniProtKB=P0DP01 P0DP01 IGHV1-8 PTHR23266:SF415 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 1-8 binding#GO:0005488;antigen binding#GO:0003823 immunoglobulin mediated immune response#GO:0016064;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449;immune effector process#GO:0002252;immune system process#GO:0002376;adaptive immune response#GO:0002250;response to stimulus#GO:0050896;immune response#GO:0006955 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=49571|UniProtKB=B4DH59 B4DH59 NBPF26 PTHR14199:SF35 NEUROBLASTOMA BREAKPOINT FAMILY MEMBER 6-LIKE PROTEIN NBPF FAMILY MEMBER NBPF1-RELATED HUMAN|HGNC=13011|UniProtKB=Q9P2Y4 Q9P2Y4 ZNF219 PTHR45925:SF1 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 219 RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=29402|UniProtKB=Q96PX1 Q96PX1 RNF157 PTHR22996:SF1 MAHOGUNIN E3 UBIQUITIN LIGASE RNF157 transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842 intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=13024|UniProtKB=Q9UIE0 Q9UIE0 ZNF230 PTHR24377:SF709 IP01015P-RELATED ZINC FINGER PROTEIN 230 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=17095|UniProtKB=Q15031 Q15031 LARS2 PTHR43740:SF3 LEUCYL-TRNA SYNTHETASE LEUCINE--TRNA LIGASE, MITOCHONDRIAL catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;ligase activity#GO:0016874 metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;macromolecule metabolic process#GO:0043170;amino acid activation#GO:0043038;tRNA aminoacylation for protein translation#GO:0006418;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;tRNA aminoacylation#GO:0043039;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;amino acid metabolic process#GO:0006520;gene expression#GO:0010467;translation#GO:0006412;mitochondrial gene expression#GO:0140053;RNA metabolic process#GO:0016070;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mitochondrial translation#GO:0032543;protein biosynthetic process#GO:0160307 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 HUMAN|HGNC=15958|UniProtKB=Q9H114 Q9H114 CSTL1 PTHR47887:SF1 CYSTATIN-LIKE 1 CYSTATIN-LIKE 1 catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;signaling receptor ligand precursor processing#GO:0140448;proteolysis#GO:0006508;metabolic process#GO:0008152;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein processing#GO:0016485 HUMAN|HGNC=26045|UniProtKB=Q9BUN1 Q9BUN1 MENT PTHR16240:SF2 PROTEIN MENT PROTEIN MENT HUMAN|HGNC=9726|UniProtKB=P11217 P11217 PYGM PTHR11468:SF32 GLYCOGEN PHOSPHORYLASE GLYCOGEN PHOSPHORYLASE, MUSCLE FORM transferase activity#GO:0016740;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;glycosyltransferase activity#GO:0016757 generation of precursor metabolites and energy#GO:0006091;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;energy derivation by oxidation of organic compounds#GO:0015980;cellular process#GO:0009987;glycogen catabolic process#GO:0005980;energy reserve metabolic process#GO:0006112;carbohydrate catabolic process#GO:0016052;polysaccharide catabolic process#GO:0000272;glycogen metabolic process#GO:0005977;glucan metabolic process#GO:0044042;primary metabolic process#GO:0044238;carbohydrate metabolic process#GO:0005975;glucan catabolic process#GO:0009251;catabolic process#GO:0009056;polysaccharide metabolic process#GO:0005976 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 transferase#PC00220;glycosyltransferase#PC00111 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Phosphorylase a#P00718;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Phosphorylase b#P00717 HUMAN|HGNC=18316|UniProtKB=Q8N895 Q8N895 ZNF366 PTHR24390:SF268 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 366 sequence-specific DNA binding#GO:0043565;nuclear estrogen receptor binding#GO:0030331;transcription corepressor activity#GO:0003714;nuclear receptor binding#GO:0016922;DNA-binding transcription factor binding#GO:0140297;transcription regulatory region nucleic acid binding#GO:0001067;RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629;protein binding#GO:0005515;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;sequence-specific double-stranded DNA binding#GO:1990837;transcription factor binding#GO:0008134;transcription coregulator activity#GO:0003712;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;regulation of signal transduction#GO:0009966;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;negative regulation of response to stimulus#GO:0048585;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of DNA-templated transcription#GO:0006355;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of signal transduction#GO:0009968;response to chemical#GO:0042221;response to hormone#GO:0009725;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of cell communication#GO:0010648;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of intracellular signal transduction#GO:1902532;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;negative regulation of metabolic process#GO:0009892;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;negative regulation of biological process#GO:0048519 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218 HUMAN|HGNC=26878|UniProtKB=A6NFQ2 A6NFQ2 TCAF2 PTHR15730:SF4 EXPERIMENTAL AUTOIMMUNE PROSTATITIS ANTIGEN 2-RELATED TRPM8 CHANNEL-ASSOCIATED FACTOR 2 binding#GO:0005488;transmembrane transporter binding#GO:0044325;protein binding#GO:0005515 regulation of protein localization#GO:0032880;regulation of localization#GO:0032879;regulation of establishment of protein localization#GO:0070201;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 HUMAN|HGNC=4319|UniProtKB=P10071 P10071 GLI3 PTHR45718:SF5 TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS TRANSCRIPTION ACTIVATOR GLI3 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700 signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;smoothened signaling pathway#GO:0007224;regulation of DNA-templated transcription#GO:0006355;cell communication#GO:0007154;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cell surface receptor signaling pathway#GO:0007166 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 Hedgehog signaling pathway#P00025>Cubitus interruptus repressor#P00687;Hedgehog signaling pathway#P00025>Cubitus interruptus#P00690 HUMAN|HGNC=7782|UniProtKB=Q16236 Q16236 NFE2L2 PTHR24411:SF3 NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR 2 RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;cellular response to chemical stimulus#GO:0070887;cellular response to stress#GO:0033554;cellular response to oxidative stress#GO:0034599;response to chemical#GO:0042221;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;response to stress#GO:0006950;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of biosynthetic process#GO:0009889;cellular response to chemical stress#GO:0062197;response to oxidative stress#GO:0006979;regulation of gene expression#GO:0010468 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 basic leucine zipper transcription factor#PC00056 HUMAN|HGNC=4242|UniProtKB=O94808 O94808 GFPT2 PTHR10937:SF10 GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING GLUTAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE [ISOMERIZING] 2 transferase activity#GO:0016740;catalytic activity#GO:0003824;transaminase activity#GO:0008483 organophosphate biosynthetic process#GO:0090407;UDP-N-acetylglucosamine metabolic process#GO:0006047;UDP-N-acetylglucosamine biosynthetic process#GO:0006048;small molecule metabolic process#GO:0044281;amino sugar metabolic process#GO:0006040;nucleoside phosphate metabolic process#GO:0006753;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;nucleoside phosphate biosynthetic process#GO:1901293;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;nucleotide-sugar metabolic process#GO:0009225;organophosphate metabolic process#GO:0019637;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987 transaminase#PC00216 N-acetylglucosamine metabolism#P02756>Fructose-6-phosphate aminotransferase#P03042;O-antigen biosynthesis#P02757>Fructose-6-phosphate aminotransferase#P03051 HUMAN|HGNC=21222|UniProtKB=Q8TF01 Q8TF01 PNISR PTHR31518:SF3 ARGININE/SERINE-RICH PROTEIN PNISR ARGININE_SERINE-RICH PROTEIN PNISR HUMAN|HGNC=16039|UniProtKB=Q9BY76 Q9BY76 ANGPTL4 PTHR19143:SF256 FIBRINOGEN/TENASCIN/ANGIOPOEITIN ANGIOPOIETIN-RELATED PROTEIN 4 enzyme inhibitor activity#GO:0004857;molecular function regulator activity#GO:0098772;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234 chemical homeostasis#GO:0048878;lipid homeostasis#GO:0055088;triglyceride homeostasis#GO:0070328;homeostatic process#GO:0042592 cellular anatomical structure#GO:0110165;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HUMAN|HGNC=20668|UniProtKB=P59942 P59942 MCCD1 PTHR37877:SF1 MITOCHONDRIAL COILED-COIL DOMAIN PROTEIN 1 MITOCHONDRIAL COILED-COIL DOMAIN PROTEIN 1 HUMAN|HGNC=4641|UniProtKB=P30711 P30711 GSTT1 PTHR43917:SF9 FAMILY NOT NAMED GLUTATHIONE S-TRANSFERASE THETA-1 transferase activity#GO:0016740;glutathione transferase activity#GO:0004364;catalytic activity#GO:0003824;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765 metabolic process#GO:0008152;glutathione metabolic process#GO:0006749;modified amino acid metabolic process#GO:0006575;sulfur compound metabolic process#GO:0006790;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 transferase#PC00220 HUMAN|HGNC=17402|UniProtKB=Q96DE9 Q96DE9 EOLA2 PTHR31666:SF0 PROTEIN CXORF40A-RELATED PROTEIN EOLA1-RELATED HUMAN|HGNC=8183|UniProtKB=P34982 P34982 OR1D2 PTHR48001:SF121 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 1D2 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 cell communication#GO:0007154;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=5880|UniProtKB=P01700 P01700 IGLV1-47 PTHR23267:SF413 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN LAMBDA VARIABLE 1-44-RELATED response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=20105|UniProtKB=Q9UPI3 Q9UPI3 FLVCR2 PTHR10924:SF3 MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED CHOLINE_ETHANOLAMINE TRANSPORTER FLVCR2 binding#GO:0005488;heme binding#GO:0020037;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;tetrapyrrole binding#GO:0046906 metal ion transport#GO:0030001;nitrogen compound transport#GO:0071705;monoatomic ion transport#GO:0006811;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;localization#GO:0051179;transport#GO:0006810;transition metal ion transport#GO:0000041;iron ion transport#GO:0006826;iron coordination entity transport#GO:1901678 cellular anatomical structure#GO:0110165;membrane#GO:0016020 secondary carrier transporter#PC00258 HUMAN|HGNC=19998|UniProtKB=O14787 O14787 TNPO2 PTHR10527:SF17 IMPORTIN BETA TRANSPORTIN-2 molecular carrier activity#GO:0140104;nucleocytoplasmic carrier activity#GO:0140142 protein localization to organelle#GO:0033365;nucleocytoplasmic transport#GO:0006913;cellular localization#GO:0051641;localization#GO:0051179;protein transport#GO:0015031;protein import into nucleus#GO:0006606;nuclear transport#GO:0051169;protein localization to nucleus#GO:0034504;macromolecule localization#GO:0033036;import into nucleus#GO:0051170;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;intracellular protein localization#GO:0008104 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 transporter#PC00227 HUMAN|HGNC=1408|UniProtKB=Q9UBN1 Q9UBN1 CACNG4 PTHR12107:SF7 VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA SUBUNIT VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-4 SUBUNIT transporter regulator activity#GO:0141108;channel activity#GO:0015267;channel regulator activity#GO:0016247;voltage-gated calcium channel activity#GO:0005245;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;passive transmembrane transporter activity#GO:0022803;molecular function regulator activity#GO:0098772;monoatomic cation channel activity#GO:0005261;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;voltage-gated channel activity#GO:0022832;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of biological quality#GO:0065008;cell communication#GO:0007154;regulation of synaptic transmission, glutamatergic#GO:0051966;localization#GO:0051179;positive regulation of signaling#GO:0023056;cellular localization#GO:0051641;localization within membrane#GO:0051668;regulation of signaling#GO:0023051;nervous system process#GO:0050877;positive regulation of synaptic transmission#GO:0050806;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regulation of trans-synaptic signaling#GO:0099177;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;transmission of nerve impulse#GO:0019226;system process#GO:0003008;regulation of postsynaptic membrane neurotransmitter receptor levels#GO:0099072 membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane region#GO:0098590;postsynaptic specialization#GO:0099572;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;neuron to neuron synapse#GO:0098984;plasma membrane#GO:0005886;signaling receptor complex#GO:0043235;synaptic membrane#GO:0097060;cell junction#GO:0030054;transporter complex#GO:1990351;membrane protein complex#GO:0098796;postsynapse#GO:0098794;plasma membrane protein complex#GO:0098797;asymmetric synapse#GO:0032279;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;postsynaptic specialization membrane#GO:0099634;postsynaptic membrane#GO:0045211;postsynaptic density#GO:0014069;transmembrane transporter complex#GO:1902495;postsynaptic density membrane#GO:0098839 voltage-gated ion channel#PC00241;transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=25972|UniProtKB=Q2M2I3 Q2M2I3 FAM83E PTHR16181:SF36 PROTEIN FAM83A-RELATED PROTEIN FAM83E protein binding#GO:0005515;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;kinase binding#GO:0019900;binding#GO:0005488 signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154 HUMAN|HGNC=16047|UniProtKB=Q9BSG0 Q9BSG0 PRADC1 PTHR22702:SF3 PROTEASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN PROTEASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN 1 HUMAN|HGNC=51235|UniProtKB=B7ZW38 B7ZW38 HNRNPCL3 PTHR13968:SF30 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN C-LIKE 3-RELATED binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 RNA metabolism protein#PC00031 HUMAN|HGNC=9650|UniProtKB=P17706 P17706 PTPN2 PTHR46047:SF1 TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 61F TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 2 kinase binding#GO:0019900;binding#GO:0005488;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;protein tyrosine phosphatase activity#GO:0004725;protein binding#GO:0005515;hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578 negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of MAPK cascade#GO:0043409;regulation of cellular process#GO:0050794;regulation of receptor signaling pathway via STAT#GO:1904892;regulation of cell communication#GO:0010646;negative regulation of cellular process#GO:0048523;regulation of MAPK cascade#GO:0043408;regulation of response to stimulus#GO:0048583;regulation of receptor signaling pathway via JAK-STAT#GO:0046425;negative regulation of ERK1 and ERK2 cascade#GO:0070373;regulation of ERK1 and ERK2 cascade#GO:0070372;negative regulation of response to stimulus#GO:0048585;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HUMAN|HGNC=19943|UniProtKB=Q9Y296 Q9Y296 TRAPPC4 PTHR23249:SF15 TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 4 guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695 endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;Golgi vesicle transport#GO:0048193;transport#GO:0006810;intracellular transport#GO:0046907;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;cellular process#GO:0009987 vesicle tethering complex#GO:0099023;TRAPP complex#GO:0030008;intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991 membrane traffic protein#PC00150 HUMAN|HGNC=26530|UniProtKB=Q96M91 Q96M91 CFAP53 PTHR31183:SF1 TRICHOPLEIN KERATIN FILAMENT-BINDING PROTEIN FAMILY MEMBER CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 53 structural protein#PC00211 HUMAN|HGNC=29596|UniProtKB=Q3YBM2 Q3YBM2 TMEM176B PTHR15756:SF7 LR8/HCA112 TRANSMEMBRANE PROTEIN 176B regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;negative regulation of immune system process#GO:0002683;regulation of developmental process#GO:0050793;negative regulation of biological process#GO:0048519;negative regulation of multicellular organismal process#GO:0051241;regulation of multicellular organismal development#GO:2000026;regulation of cell development#GO:0060284;regulation of biological process#GO:0050789;regulation of hemopoiesis#GO:1903706;negative regulation of cellular process#GO:0048523;regulation of cell differentiation#GO:0045595 HUMAN|HGNC=7880|UniProtKB=O95628 O95628 CNOT4 PTHR12603:SF0 CCR4-NOT TRANSCRIPTION COMPLEX RELATED CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 4 acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;ubiquitin-protein transferase activity#GO:0004842 regulation of RNA stability#GO:0043487;protein metabolic process#GO:0019538;regulation of RNA metabolic process#GO:0051252;RNA decapping#GO:0110154;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;positive regulation of mRNA catabolic process#GO:0061014;modification-dependent protein catabolic process#GO:0019941;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;nuclear-transcribed mRNA poly(A) tail shortening#GO:0000289;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;positive regulation of catabolic process#GO:0009896;macromolecule metabolic process#GO:0043170;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;regulation of gene expression#GO:0010468;ubiquitin-dependent protein catabolic process#GO:0006511;regulation of catabolic process#GO:0009894;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;nucleobase-containing compound catabolic process#GO:0034655;regulation of primary metabolic process#GO:0080090;nucleic acid catabolic process#GO:0141188;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;RNA catabolic process#GO:0006401;RNA metabolic process#GO:0016070;positive regulation of metabolic process#GO:0009893;regulation of biological quality#GO:0065008;negative regulation of gene expression#GO:0010629;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of mRNA stability#GO:0043488;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;macromolecule catabolic process#GO:0009057;positive regulation of mRNA metabolic process#GO:1903313;mRNA destabilization#GO:0061157;metabolic process#GO:0008152;regulation of mRNA metabolic process#GO:1903311;RNA destabilization#GO:0050779;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604 CCR4-NOT complex#GO:0030014;protein-containing complex#GO:0032991;intracellular protein-containing complex#GO:0140535 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=1163|UniProtKB=Q9H5F2 Q9H5F2 CFAP68 PTHR34524:SF1 CALCYPHOSIN CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 68 calcium-binding protein#PC00060;calmodulin-related#PC00061 HUMAN|HGNC=10683|UniProtKB=O14521 O14521 SDHD PTHR13337:SF6 SUCCINATE DEHYDROGENASE SUCCINATE DEHYDROGENASE [UBIQUINONE] CYTOCHROME B SMALL SUBUNIT, MITOCHONDRIAL binding#GO:0005488;small molecule binding#GO:0036094;heme binding#GO:0020037;tetrapyrrole binding#GO:0046906 metabolic process#GO:0008152;aerobic electron transport chain#GO:0019646;generation of precursor metabolites and energy#GO:0006091;mitochondrial electron transport, succinate to ubiquinone#GO:0006121;ATP synthesis coupled electron transport#GO:0042773;oxidative phosphorylation#GO:0006119;energy derivation by oxidation of organic compounds#GO:0015980;cellular respiration#GO:0045333;aerobic respiration#GO:0009060;primary metabolic process#GO:0044238;tricarboxylic acid cycle#GO:0006099;electron transport chain#GO:0022900;mitochondrial ATP synthesis coupled electron transport#GO:0042775;respiratory electron transport chain#GO:0022904;cellular process#GO:0009987 catalytic complex#GO:1902494;respiratory chain complex II (succinate dehydrogenase)#GO:0045273;respiratory chain complex#GO:0098803;membrane#GO:0016020;oxidoreductase complex#GO:1990204;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 oxidoreductase#PC00176 HUMAN|HGNC=11780|UniProtKB=P49221 P49221 TGM4 PTHR11590:SF70 PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE 4 catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 cellular anatomical structure#GO:0110165;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576 transferase#PC00220 HUMAN|HGNC=21481|UniProtKB=Q9BYZ2 Q9BYZ2 LDHAL6B PTHR43128:SF8 L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+)) L-LACTATE DEHYDROGENASE A-LIKE 6B oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 energy derivation by oxidation of organic compounds#GO:0015980;generation of precursor metabolites and energy#GO:0006091;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;pyruvate metabolic process#GO:0006090;small molecule catabolic process#GO:0044282;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;monocarboxylic acid catabolic process#GO:0072329;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 dehydrogenase#PC00092;oxidoreductase#PC00176 HUMAN|HGNC=1492|UniProtKB=Q9UHJ6 Q9UHJ6 SHPK PTHR10196:SF67 SUGAR KINASE SEDOHEPTULOKINASE phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740 small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;regulation of leukocyte activation#GO:0002694;phosphorus metabolic process#GO:0006793;purine nucleotide metabolic process#GO:0006163;regulation of biological process#GO:0050789;response to molecule of bacterial origin#GO:0002237;regulation of cell activation#GO:0050865;purine-containing compound metabolic process#GO:0072521;nucleotide metabolic process#GO:0009117;cellular response to chemical stimulus#GO:0070887;response to oxygen-containing compound#GO:1901700;glyceraldehyde-3-phosphate metabolic process#GO:0019682;response to chemical#GO:0042221;response to lipid#GO:0033993;cellular response to lipid#GO:0071396;regulation of multicellular organismal process#GO:0051239;response to biotic stimulus#GO:0009607;NADP+ metabolic process#GO:0006739;cellular response to lipopolysaccharide#GO:0071222;cellular response to oxygen-containing compound#GO:1901701;nicotinamide nucleotide metabolic process#GO:0046496;regulation of macrophage activation#GO:0043030;aldehyde metabolic process#GO:0006081;cellular process#GO:0009987;response to lipopolysaccharide#GO:0032496;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;glucose 6-phosphate metabolic process#GO:0051156;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;response to external biotic stimulus#GO:0043207;pentose-phosphate shunt, non-oxidative branch#GO:0009052;nucleoside phosphate metabolic process#GO:0006753;cellular response to biotic stimulus#GO:0071216;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;response to bacterium#GO:0009617;pentose-phosphate shunt#GO:0006098;pyridine-containing compound metabolic process#GO:0072524;NADPH regeneration#GO:0006740;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;response to other organism#GO:0051707;organophosphate metabolic process#GO:0019637;carbohydrate derivative metabolic process#GO:1901135;cellular response to molecule of bacterial origin#GO:0071219;response to external stimulus#GO:0009605;generation of precursor metabolites and energy#GO:0006091 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 carbohydrate kinase#PC00065;kinase#PC00137 HUMAN|HGNC=26153|UniProtKB=Q68E01 Q68E01 INTS3 PTHR13587:SF7 INTEGRATOR COMPLEX SUBUNIT 3 INTEGRATOR COMPLEX SUBUNIT 3 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=16914|UniProtKB=O75325 O75325 LRRN2 PTHR24373:SF162 SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN LEUCINE-RICH REPEAT NEURONAL PROTEIN 2 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=13390|UniProtKB=Q9GZT8 Q9GZT8 NIF3L1 PTHR13799:SF13 NGG1 INTERACTING FACTOR 3 NIF3-LIKE PROTEIN 1 mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=10918|UniProtKB=Q13336 Q13336 SLC14A1 PTHR10464:SF5 UREA TRANSPORTER UREA TRANSPORTER 1 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;cellular process#GO:0009987;transport#GO:0006810;nitrogen compound transport#GO:0071705 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227 HUMAN|HGNC=26846|UniProtKB=Q86WS4 Q86WS4 REDIC1 PTHR35158:SF1 CDNA SEQUENCE CN725425 REGULATOR OF DNA CLASS I CROSSOVER INTERMEDIATES 1 HUMAN|HGNC=20137|UniProtKB=Q6ZVK1 Q6ZVK1 TMEM179 PTHR31872:SF4 TRANSMEMBRANE PROTEIN 179 TRANSMEMBRANE PROTEIN 179 HUMAN|HGNC=14727|UniProtKB=Q8NH03 Q8NH03 OR2T3 PTHR26453:SF4 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2T3-RELATED olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 detection of chemical stimulus#GO:0009593;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;response to chemical#GO:0042221;response to stimulus#GO:0050896;nervous system process#GO:0050877;sensory perception#GO:0007600;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;system process#GO:0003008 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=7162|UniProtKB=P51512 P51512 MMP16 PTHR10201:SF26 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE-16 peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 multicellular organismal process#GO:0032501;catabolic process#GO:0009056;cellular process#GO:0009987;cellular component organization#GO:0016043;external encapsulating structure organization#GO:0045229;system development#GO:0048731;anatomical structure development#GO:0048856;extracellular matrix organization#GO:0030198;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;skeletal system development#GO:0001501;developmental process#GO:0032502;animal gross anatomical part developmental process#GO:0160108;extracellular structure organization#GO:0043062;metabolic process#GO:0008152 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;extracellular region#GO:0005576;membrane#GO:0016020 metalloprotease#PC00153 Alzheimer disease-presenilin pathway#P00004>Membrane metalloprotease#P00141;Alzheimer disease-presenilin pathway#P00004>Matrix metalloprotease#P00130 HUMAN|HGNC=13584|UniProtKB=Q9UKT4 Q9UKT4 FBXO5 PTHR15493:SF8 F-BOX ONLY PROTEIN 5 AND 43 F-BOX ONLY PROTEIN 5 enzyme inhibitor activity#GO:0004857;molecular function inhibitor activity#GO:0140678;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234 negative regulation of mitotic metaphase/anaphase transition#GO:0045841;negative regulation of cellular component organization#GO:0051129;negative regulation of organelle organization#GO:0010639;cell cycle#GO:0007049;regulation of cell cycle phase transition#GO:1901987;regulation of cellular process#GO:0050794;cell cycle phase transition#GO:0044770;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;mitotic cell cycle#GO:0000278;negative regulation of chromosome organization#GO:2001251;mitotic cell cycle phase transition#GO:0044772;regulation of mitotic sister chromatid segregation#GO:0033047;regulation of G2/M transition of mitotic cell cycle#GO:0010389;regulation of mitotic cell cycle#GO:0007346;positive regulation of cellular process#GO:0048522;regulation of cell cycle G2/M phase transition#GO:1902749;regulation of nuclear division#GO:0051783;negative regulation of nuclear division#GO:0051784;biological regulation#GO:0065007;regulation of mitotic metaphase/anaphase transition#GO:0030071;regulation of reproductive process#GO:2000241;negative regulation of cell cycle process#GO:0010948;regulation of chromosome organization#GO:0033044;negative regulation of cellular process#GO:0048523;positive regulation of mitotic cell cycle#GO:0045931;regulation of mitotic nuclear division#GO:0007088;mitotic cell cycle process#GO:1903047;negative regulation of chromosome separation#GO:1905819;regulation of mitotic sister chromatid separation#GO:0010965;cell cycle process#GO:0022402;regulation of organelle organization#GO:0033043;negative regulation of mitotic nuclear division#GO:0045839;regulation of biological process#GO:0050789;positive regulation of cell cycle process#GO:0090068;regulation of meiotic cell cycle#GO:0051445;negative regulation of cell cycle phase transition#GO:1901988;negative regulation of biological process#GO:0048519;regulation of sister chromatid segregation#GO:0033045;regulation of cell cycle#GO:0051726;regulation of cellular component organization#GO:0051128;negative regulation of mitotic sister chromatid separation#GO:2000816;negative regulation of mitotic cell cycle#GO:0045930;regulation of mitotic cell cycle phase transition#GO:1901990;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;cell cycle G1/S phase transition#GO:0044843;negative regulation of sister chromatid segregation#GO:0033046;positive regulation of cell cycle#GO:0045787;regulation of cell cycle process#GO:0010564;regulation of chromosome separation#GO:1905818;negative regulation of mitotic cell cycle phase transition#GO:1901991;negative regulation of metaphase/anaphase transition of cell cycle#GO:1902100;regulation of chromosome segregation#GO:0051983;negative regulation of mitotic sister chromatid segregation#GO:0033048;G1/S transition of mitotic cell cycle#GO:0000082;negative regulation of chromosome segregation#GO:0051985;negative regulation of cell cycle#GO:0045786 nucleus#GO:0005634;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;spindle#GO:0005819;cytoskeleton#GO:0005856;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 HUMAN|HGNC=13587|UniProtKB=Q9NRD0 Q9NRD0 FBXO8 PTHR10663:SF372 GUANYL-NUCLEOTIDE EXCHANGE FACTOR F-BOX ONLY PROTEIN 8 guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=31864|UniProtKB=P0DM35 P0DM35 MT1HL1 PTHR23299:SF58 METALLOTHIONEIN METALLOTHIONEIN 1H-LIKE PROTEIN 1 cation binding#GO:0043169;metal ion binding#GO:0046872;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167 response to stimulus#GO:0050896;response to toxic substance#GO:0009636;homeostatic process#GO:0042592;intracellular monoatomic ion homeostasis#GO:0006873;cellular response to stimulus#GO:0051716;cellular response to chemical stimulus#GO:0070887;inorganic ion homeostasis#GO:0098771;response to chemical#GO:0042221;detoxification#GO:0098754;response to stress#GO:0006950;detoxification of inorganic compound#GO:0061687;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;response to cadmium ion#GO:0046686;response to metal ion#GO:0010038;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;intracellular monoatomic cation homeostasis#GO:0030003 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 defense/immunity protein#PC00090 HUMAN|HGNC=30738|UniProtKB=B2RN74 B2RN74 OR11H12 PTHR24242:SF201 G-PROTEIN COUPLED RECEPTOR OLFACTORY RECEPTOR 11H1-RELATED G-protein coupled receptor#PC00021 HUMAN|HGNC=4486|UniProtKB=O00270 O00270 GPR31 PTHR46048:SF7 HYDROXYCARBOXYLIC ACID RECEPTOR 2 12-(S)-HYDROXY-5,8,10,14-EICOSATETRAENOIC ACID RECEPTOR signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;bioactive lipid receptor activity#GO:0045125 regulation of defense response#GO:0031347;regulation of inflammatory response#GO:0050727;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;negative regulation of biological process#GO:0048519;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;negative regulation of inflammatory response#GO:0050728;negative regulation of defense response#GO:0031348;regulation of response to stimulus#GO:0048583;regulation of response to stress#GO:0080134;signal transduction#GO:0007165;cellular process#GO:0009987;negative regulation of response to external stimulus#GO:0032102;biological regulation#GO:0065007;negative regulation of response to stimulus#GO:0048585;regulation of response to external stimulus#GO:0032101 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=25537|UniProtKB=Q9NVU7 Q9NVU7 SDAD1 PTHR12730:SF1 HSDA/SDA1-RELATED PROTEIN SDA1 HOMOLOG ribosomal large subunit biogenesis#GO:0042273;organelle localization#GO:0051640;ribosome biogenesis#GO:0042254;ribosome localization#GO:0033750;nucleocytoplasmic transport#GO:0006913;localization#GO:0051179;cellular localization#GO:0051641;nuclear transport#GO:0051169;nuclear export#GO:0051168;ribosomal large subunit export from nucleus#GO:0000055;establishment of organelle localization#GO:0051656;ribonucleoprotein complex biogenesis#GO:0022613;intracellular transport#GO:0046907;ribosomal subunit export from nucleus#GO:0000054;transport#GO:0006810;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;cellular component biogenesis#GO:0044085;establishment of localization in cell#GO:0051649;cellular process#GO:0009987 membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634 HUMAN|HGNC=28606|UniProtKB=Q0VDE8 Q0VDE8 ADIG PTHR38499:SF1 ADIPOGENIN ADIPOGENIN HUMAN|HGNC=31922|UniProtKB=O15083 O15083 ERC2 PTHR18861:SF3 ELKS/RAB6-INTERACTING/CAST PROTEIN ERC PROTEIN 2 structural molecule activity#GO:0005198;structural constituent of synapse#GO:0098918 cell junction organization#GO:0034330;cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;cellular process#GO:0009987;synapse organization#GO:0050808 intracellular anatomical structure#GO:0005622;presynaptic active zone#GO:0048786;cell junction#GO:0030054;cell periphery#GO:0071944;cell cortex#GO:0005938;presynapse#GO:0098793;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;synapse#GO:0045202 membrane traffic protein#PC00150 HUMAN|HGNC=5824|UniProtKB=A0A087WSY6 A0A087WSY6 IGKV3D-15 PTHR23267:SF331 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN KAPPA VARIABLE 3-15-RELATED response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=17091|UniProtKB=Q92542 Q92542 NCSTN PTHR21092:SF1 NICASTRIN NICASTRIN biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604;protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;proteolysis#GO:0006508 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 Alzheimer disease-presenilin pathway#P00004>Nicastrin#P00115;Notch signaling pathway#P00045>Nicastrin#P01108;Alzheimer disease-amyloid secretase pathway#P00003>Nicastrin#P00095 HUMAN|HGNC=30615|UniProtKB=Q5M775 Q5M775 SPECC1 PTHR23167:SF3 CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED CYTOSPIN-B cellular process#GO:0009987;actin filament-based process#GO:0030029;organelle organization#GO:0006996;cellular component organization#GO:0016043;cytoskeleton organization#GO:0007010;cellular component organization or biogenesis#GO:0071840;actin cytoskeleton organization#GO:0030036 microtubule cytoskeleton#GO:0015630;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;actin filament#GO:0005884;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;actin cytoskeleton#GO:0015629;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HUMAN|HGNC=20309|UniProtKB=Q9Y2L9 Q9Y2L9 LRCH1 PTHR16083:SF10 LEUCINE RICH REPEAT CONTAINING PROTEIN LEUCINE-RICH REPEAT AND CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN 1 regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;negative regulation of biological process#GO:0048519;cellular response to chemokine#GO:1990869;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of leukocyte migration#GO:0002685;regulation of lymphocyte migration#GO:2000401;response to peptide#GO:1901652;regulation of cell motility#GO:2000145;response to chemokine#GO:1990868;regulation of locomotion#GO:0040012;negative regulation of locomotion#GO:0040013;biological regulation#GO:0065007;negative regulation of immune system process#GO:0002683;negative regulation of cell motility#GO:2000146;response to cytokine#GO:0034097;response to chemical#GO:0042221;regulation of cell migration#GO:0030334;negative regulation of cellular process#GO:0048523;negative regulation of cell migration#GO:0030336 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 scaffold/adaptor protein#PC00226 HUMAN|HGNC=6364|UniProtKB=P07288 P07288 KLK3 PTHR24271:SF73 KALLIKREIN-RELATED PROSTATE-SPECIFIC ANTIGEN catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171 macromolecule metabolic process#GO:0043170;system process#GO:0003008;metabolic process#GO:0008152;multicellular organismal process#GO:0032501;protein maturation#GO:0051604;gene expression#GO:0010467;blood circulation#GO:0008015;biosynthetic process#GO:0009058;biological regulation#GO:0065007;regulation of systemic arterial blood pressure#GO:0003073;regulation of blood pressure#GO:0008217;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein processing#GO:0016485;protein metabolic process#GO:0019538;regulation of biological quality#GO:0065008;circulatory system process#GO:0003013;proteolysis#GO:0006508;primary metabolic process#GO:0044238;zymogen activation#GO:0031638 secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;extracellular region#GO:0005576;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;secretory vesicle#GO:0099503 serine protease#PC00203 HUMAN|HGNC=29164|UniProtKB=Q9Y2I9 Q9Y2I9 TBC1D30 PTHR22957:SF601 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN TBC1 DOMAIN FAMILY MEMBER 30 enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme activator activity#GO:0008047 protein-binding activity modulator#PC00095;G-protein modulator#PC00022;GTPase-activating protein#PC00257 HUMAN|HGNC=5127|UniProtKB=Q00444 Q00444 HOXC5 PTHR45659:SF5 HOMEOBOX PROTEIN HOX HOMEOBOX PROTEIN HOX-C5 double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of nucleobase-containing compound metabolic process#GO:0019219;regionalization#GO:0003002;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;anterior/posterior pattern specification#GO:0009952;developmental process#GO:0032502;multicellular organism development#GO:0007275;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;pattern specification process#GO:0007389;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 HUMAN|HGNC=23663|UniProtKB=Q9BQB6 Q9BQB6 VKORC1 PTHR14519:SF8 VITAMIN K EPOXIDE REDUCTASE COMPLEX, SUBUNIT 1 VITAMIN K EPOXIDE REDUCTASE COMPLEX SUBUNIT 1 catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 vitamin K metabolic process#GO:0042373;response to stress#GO:0006950;ketone metabolic process#GO:0042180;response to wounding#GO:0009611;hemostasis#GO:0007599;cellular process#GO:0009987;coagulation#GO:0050817;multicellular organismal process#GO:0032501;regulation of body fluid levels#GO:0050878;response to stimulus#GO:0050896;biological regulation#GO:0065007;metabolic process#GO:0008152;wound healing#GO:0042060;blood coagulation#GO:0007596;regulation of biological quality#GO:0065008 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HUMAN|HGNC=8703|UniProtKB=Q9Y5G8 Q9Y5G8 PCDHGA5 PTHR24028:SF105 CADHERIN-87A PROTOCADHERIN GAMMA-A5 cellular process#GO:0009987;cell adhesion#GO:0007155 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HUMAN|HGNC=12624|UniProtKB=Q9UHP3 Q9UHP3 USP25 PTHR24006:SF666 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 25 deubiquitinase activity#GO:0101005;binding#GO:0005488;protein binding#GO:0005515;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;cysteine-type deubiquitinase activity#GO:0004843;cysteine-type peptidase activity#GO:0008234;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096 regulation of biological quality#GO:0065008;biological regulation#GO:0065007;regulation of protein stability#GO:0031647 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 cysteine protease#PC00081;protease#PC00190 HUMAN|HGNC=20407|UniProtKB=Q96L12 Q96L12 CALR3 PTHR11073:SF3 CALRETICULIN AND CALNEXIN CALRETICULIN-3 cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;response to stress#GO:0006950;proteasomal protein catabolic process#GO:0010498;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604;response to chemical#GO:0042221;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;protein folding#GO:0006457;catabolic process#GO:0009056;response to stimulus#GO:0050896;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;response to endoplasmic reticulum stress#GO:0034976;ERAD pathway#GO:0036503;protein metabolic process#GO:0019538 membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090 chaperone#PC00072 HUMAN|HGNC=13490|UniProtKB=Q9Y4E6 Q9Y4E6 WDR7 PTHR44099:SF3 RABCONNECTIN-3B, ISOFORM A WD REPEAT-CONTAINING PROTEIN 7 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=23046|UniProtKB=Q5SYC1 Q5SYC1 CLVS2 PTHR10174:SF73 ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED CLAVESIN-2 ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;anion binding#GO:0043168;phosphatidylinositol bisphosphate binding#GO:1902936 lytic vacuole organization#GO:0080171;lysosome organization#GO:0007040;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;vacuole organization#GO:0007033;cellular component organization or biogenesis#GO:0071840 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;coated vesicle#GO:0030135;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;endomembrane system#GO:0012505;Golgi apparatus subcompartment#GO:0098791;Golgi apparatus#GO:0005794;clathrin-coated vesicle#GO:0030136 transfer/carrier protein#PC00219 HUMAN|HGNC=16001|UniProtKB=Q9HAC7 Q9HAC7 SUGCT PTHR48207:SF3 SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE SUCCINYL-COA:GLUTARATE COA-TRANSFERASE transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring sulphur-containing groups#GO:0016782 mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 transferase#PC00220;metabolite interconversion enzyme#PC00262 Carnitine metabolism#P02733>Carnitine dehydratase#P02866;Coenzyme A linked carnitine metabolism#P02732>L-carnitine dehydratase#P02864 HUMAN|HGNC=14772|UniProtKB=Q8NGR1 Q8NGR1 OR13A1 PTHR26452:SF125 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 13A1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 system process#GO:0003008;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;nervous system process#GO:0050877;sensory perception#GO:0007600;sensory perception of chemical stimulus#GO:0007606 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=17312|UniProtKB=O14925 O14925 TIMM23 PTHR15371:SF39 TIM23 MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM23 transmembrane protein transporter activity#GO:0008320;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 establishment of localization#GO:0051234;intracellular protein transmembrane transport#GO:0065002;establishment of protein localization to organelle#GO:0072594;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;transport#GO:0006810;intracellular protein transport#GO:0006886;protein transmembrane transport#GO:0071806;protein transmembrane import into intracellular organelle#GO:0044743;protein import into mitochondrial matrix#GO:0030150;mitochondrial protein import pathway#GO:7770058;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular localization#GO:0051641;transmembrane transport#GO:0055085;localization#GO:0051179;protein transport#GO:0015031;mitochondrial transmembrane transport#GO:1990542;protein localization to organelle#GO:0033365;mitochondrial transport#GO:0006839;protein localization to mitochondrion#GO:0070585 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;TIM23 mitochondrial import inner membrane translocase complex#GO:0005744;mitochondrial membrane#GO:0031966;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;organelle membrane#GO:0031090;inner mitochondrial membrane protein complex#GO:0098800;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;organelle envelope#GO:0031967;membrane protein complex#GO:0098796;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 transporter#PC00227;amino acid transporter#PC00046;secondary carrier transporter#PC00258 HUMAN|HGNC=29196|UniProtKB=Q5BKX6 Q5BKX6 SLC45A4 PTHR19432:SF7 SUGAR TRANSPORTER POLYAMINE-TRANSPORTER SLC45A4 secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;proton transmembrane transporter activity#GO:0015078;active transmembrane transporter activity#GO:0022804;solute:monoatomic cation symporter activity#GO:0015294;monoatomic ion transmembrane transporter activity#GO:0015075;symporter activity#GO:0015293;solute:proton symporter activity#GO:0015295;monoatomic cation transmembrane transporter activity#GO:0008324;carbohydrate transmembrane transporter activity#GO:0015144 cellular anatomical structure#GO:0110165;membrane#GO:0016020 secondary carrier transporter#PC00258 HUMAN|HGNC=29132|UniProtKB=O94929 O94929 ABLIM3 PTHR24213:SF0 ACTIN-BINDING LIM PROTEIN ACTIN-BINDING LIM PROTEIN 3 cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;actin filament binding#GO:0051015;binding#GO:0005488;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 cilium organization#GO:0044782;cellular component organization or biogenesis#GO:0071840;organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cell projection organization#GO:0030030;cell projection assembly#GO:0030031;lamellipodium assembly#GO:0030032;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cilium assembly#GO:0060271;cellular component organization#GO:0016043 intracellular anatomical structure#GO:0005622;actin filament bundle#GO:0032432;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;stress fiber#GO:0001725;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165;actomyosin#GO:0042641;actin cytoskeleton#GO:0015629 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=11141|UniProtKB=O76070 O76070 SNCG PTHR13820:SF10 SYNUCLEIN GAMMA-SYNUCLEIN cation binding#GO:0043169;metal ion binding#GO:0046872;transition metal ion binding#GO:0046914;ion binding#GO:0043167;binding#GO:0005488;copper ion binding#GO:0005507;small molecule binding#GO:0036094 cellular component organization or biogenesis#GO:0071840;vesicle-mediated transport in synapse#GO:0099003;import into cell#GO:0098657;establishment of localization#GO:0051234;transport#GO:0006810;synaptic vesicle cycle#GO:0099504;vesicle-mediated transport#GO:0016192;synaptic vesicle recycling#GO:0036465;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;synaptic signaling#GO:0099536;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;localization#GO:0051179;cell communication#GO:0007154;cellular localization#GO:0051641;trans-synaptic signaling#GO:0099537;synapse organization#GO:0050808;anterograde trans-synaptic signaling#GO:0098916;cell junction organization#GO:0034330;endocytosis#GO:0006897;signaling#GO:0023052;synaptic vesicle endocytosis#GO:0048488;cellular component organization#GO:0016043;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789 cell body#GO:0044297;synapse#GO:0045202;cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;distal axon#GO:0150034;neuronal cell body#GO:0043025;neuron projection terminus#GO:0044306;cell projection#GO:0042995;axon#GO:0030424;intracellular anatomical structure#GO:0005622;presynapse#GO:0098793;neuron projection#GO:0043005;cytoplasm#GO:0005737;somatodendritic compartment#GO:0036477;cell junction#GO:0030054;axon terminus#GO:0043679 membrane traffic protein#PC00150;membrane trafficking regulatory protein#PC00151 Parkinson disease#P00049>gamma-Synuclein#P01231 HUMAN|HGNC=3803|UniProtKB=O60548 O60548 FOXD2 PTHR11829:SF348 FORKHEAD BOX PROTEIN FORKHEAD BOX PROTEIN D1-RELATED RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of RNA metabolic process#GO:0051252;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=18291|UniProtKB=Q9NPF5 Q9NPF5 DMAP1 PTHR12855:SF10 DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1 FAMILY MEMBER DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1 transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of transcription by RNA polymerase II#GO:0000122 chromatin#GO:0000785;intracellular membraneless organelle#GO:0043232;NuA4 histone acetyltransferase complex#GO:0035267;protein-containing complex#GO:0032991;histone acetyltransferase complex#GO:0000123;nuclear protein-containing complex#GO:0140513;organelle lumen#GO:0043233;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;protein acetyltransferase complex#GO:0031248;ATPase complex#GO:1904949;intracellular organelle lumen#GO:0070013;acetyltransferase complex#GO:1902493;nucleus#GO:0005634;histone deacetylase complex#GO:0000118;membrane-enclosed lumen#GO:0031974;nuclear chromosome#GO:0000228;H4 histone acetyltransferase complex#GO:1902562;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;SWI/SNF superfamily-type complex#GO:0070603;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;Swr1 complex#GO:0000812;membrane-bounded organelle#GO:0043227;INO80-type complex#GO:0097346;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=28391|UniProtKB=Q96L08 Q96L08 SUSD3 PTHR46879:SF1 SUSHI DOMAIN-CONTAINING PROTEIN 3 SUSHI DOMAIN-CONTAINING PROTEIN 3 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HUMAN|HGNC=18368|UniProtKB=Q9UM07 Q9UM07 PADI4 PTHR10837:SF24 PEPTIDYLARGININE DEIMINASE PROTEIN-ARGININE DEIMINASE TYPE-4 catalytic activity#GO:0003824;histone modifying activity#GO:0140993;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 chromatin organization#GO:0006325;chromatin remodeling#GO:0006338;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=23218|UniProtKB=Q8IWJ2 Q8IWJ2 GCC2 PTHR18902:SF25 NUCLEAR MITOTIC APPARATUS PROTEIN 1-RELATED GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN 2 localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;endosomal transport#GO:0016197;intracellular transport#GO:0046907;transport#GO:0006810;Golgi vesicle transport#GO:0048193;vesicle-mediated transport#GO:0016192;cytosolic transport#GO:0016482;retrograde transport, endosome to Golgi#GO:0042147;establishment of localization in cell#GO:0051649;cellular process#GO:0009987 membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;Golgi apparatus subcompartment#GO:0098791 cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=5385|UniProtKB=O43837 O43837 IDH3B PTHR11835:SF84 DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT BETA, MITOCHONDRIAL oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824 aerobic respiration#GO:0009060;energy derivation by oxidation of organic compounds#GO:0015980;cellular respiration#GO:0045333;generation of precursor metabolites and energy#GO:0006091;alcohol metabolic process#GO:0006066;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;secondary alcohol metabolic process#GO:1902652;small molecule metabolic process#GO:0044281;cellular process#GO:0009987;primary metabolic process#GO:0044238;tricarboxylic acid cycle#GO:0006099;carboxylic acid metabolic process#GO:0019752 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739 dehydrogenase#PC00092;oxidoreductase#PC00176 HUMAN|HGNC=28464|UniProtKB=A0PJW6 A0PJW6 TMEM223 PTHR14549:SF2 TRANSMEMBRANE PROTEIN 223 TRANSMEMBRANE PROTEIN 223 HUMAN|HGNC=24974|UniProtKB=Q8IZ69 Q8IZ69 TRMT2A PTHR45904:SF2 TRNA (URACIL-5-)-METHYLTRANSFERASE TRNA (URACIL-5-)-METHYLTRANSFERASE HOMOLOG A RNA methyltransferase#PC00033 HUMAN|HGNC=35118|UniProtKB=A8MZF0 A8MZF0 PRR33 PTHR38004:SF1 PROLINE-RICH PROTEIN 33 PROLINE-RICH PROTEIN 33 HUMAN|HGNC=21095|UniProtKB=Q5TGJ6 Q5TGJ6 HDGFL1 PTHR12550:SF85 HEPATOMA-DERIVED GROWTH FACTOR-RELATED HEPATOMA-DERIVED GROWTH FACTOR-LIKE PROTEIN 1 cellular component organization or biogenesis#GO:0071840;chromatin remodeling#GO:0006338;chromatin organization#GO:0006325;cellular component organization#GO:0016043;cellular process#GO:0009987 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 transcription cofactor#PC00217;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=316|UniProtKB=P43652 P43652 AFM PTHR11385:SF18 SERUM ALBUMIN-RELATED AFAMIN heterocyclic compound binding#GO:1901363;small molecule binding#GO:0036094;binding#GO:0005488 response to nutrient levels#GO:0031667;transport#GO:0006810;response to stimulus#GO:0050896;localization#GO:0051179;vitamin transport#GO:0051180;establishment of localization#GO:0051234 transfer/carrier protein#PC00219 HUMAN|HGNC=9705|UniProtKB=P15151 P15151 PVR PTHR23277:SF109 NECTIN-RELATED POLIOVIRUS RECEPTOR cell adhesion mediator activity#GO:0098631;cell adhesion molecule binding#GO:0050839;binding#GO:0005488;protein binding#GO:0005515;virus receptor activity#GO:0001618 cell adhesion#GO:0007155;immune system process#GO:0002376;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;natural killer cell mediated immunity#GO:0002228;leukocyte mediated cytotoxicity#GO:0001909;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;immune effector process#GO:0002252;cell killing#GO:0001906;response to external stimulus#GO:0009605;defense response#GO:0006952;natural killer cell mediated cytotoxicity#GO:0042267;innate immune response#GO:0045087;defense response to symbiont#GO:0140546;immune response#GO:0006955;cellular process#GO:0009987;heterophilic cell-cell adhesion#GO:0007157;homophilic cell-cell adhesion#GO:0007156;response to biotic stimulus#GO:0009607;cell-cell adhesion#GO:0098609;response to stress#GO:0006950;response to other organism#GO:0051707;defense response to other organism#GO:0098542 cell junction#GO:0030054;anchoring junction#GO:0070161;adherens junction#GO:0005912;cell-cell junction#GO:0005911;membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cell adhesion molecule#PC00069 HUMAN|HGNC=23706|UniProtKB=Q8N8L2 Q8N8L2 ZNF491 PTHR24381:SF427 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 491 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=25993|UniProtKB=Q8TBJ4 Q8TBJ4 PLPPR1 PTHR10165:SF41 LIPID PHOSPHATE PHOSPHATASE PHOSPHOLIPID PHOSPHATASE-RELATED PROTEIN TYPE 1 phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578 signaling#GO:0023052;phospholipid metabolic process#GO:0006644;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;phosphate-containing compound metabolic process#GO:0006796;cellular response to stimulus#GO:0051716;phospholipid dephosphorylation#GO:0046839;regulation of biological process#GO:0050789;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;dephosphorylation#GO:0016311;cell communication#GO:0007154;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;organophosphate metabolic process#GO:0019637;lipid modification#GO:0030258;lipid metabolic process#GO:0006629;metabolic process#GO:0008152 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 hydrolase#PC00121;phosphatase#PC00181 HUMAN|HGNC=28639|UniProtKB=Q6UWP2 Q6UWP2 DHRS11 PTHR43115:SF4 DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 11 DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 11 oxidoreductase#PC00176 HUMAN|HGNC=26014|UniProtKB=Q9NX74 Q9NX74 DUS2 PTHR45936:SF1 TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;oxidoreductase activity#GO:0016491;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;tRNA modification#GO:0006400;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HUMAN|HGNC=29029|UniProtKB=O43156 O43156 TTI1 PTHR18460:SF3 TEL2 INTERACTING PROTEIN 1 TTI1 FAMILY MEMBER TELO2-INTERACTING PROTEIN 1 HOMOLOG intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=7315|UniProtKB=P11836 P11836 MS4A1 PTHR23320:SF79 MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED B-LYMPHOCYTE ANTIGEN CD20 cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897 transporter#PC00227 HUMAN|HGNC=12370|UniProtKB=Q9BYV8 Q9BYV8 CEP41 PTHR44390:SF1 CENTROSOMAL PROTEIN OF 41 KDA CENTROSOMAL PROTEIN OF 41 KDA cilium organization#GO:0044782;cellular component organization or biogenesis#GO:0071840;organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cell projection organization#GO:0030030;cell projection assembly#GO:0030031;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cellular component organization#GO:0016043 cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microtubule cytoskeleton#GO:0015630;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;cilium#GO:0005929;intracellular organelle#GO:0043229;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;ciliary basal body#GO:0036064 HUMAN|HGNC=34379|UniProtKB=A6NEY8 A6NEY8 PRORSD1P PTHR31423:SF3 YBAK DOMAIN-CONTAINING PROTEIN PROLYL-TRNA SYNTHETASE ASSOCIATED DOMAIN-CONTAINING PROTEIN 1-RELATED HUMAN|HGNC=4890|UniProtKB=P36980 P36980 CFHR2 PTHR45785:SF12 COMPLEMENT FACTOR H-RELATED COMPLEMENT FACTOR H-RELATED PROTEIN 1-RELATED binding#GO:0005488;complement binding#GO:0001848;protein binding#GO:0005515 positive regulation of immune system process#GO:0002684;immune response#GO:0006955;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;complement activation#GO:0006956;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;humoral immune response#GO:0006959;regulation of response to stimulus#GO:0048583;immune effector process#GO:0002252;positive regulation of immune response#GO:0050778;regulation of biological process#GO:0050789;regulation of immune system process#GO:0002682;response to stimulus#GO:0050896;immune system process#GO:0002376;regulation of immune response#GO:0050776 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 complement component#PC00078 HUMAN|HGNC=2728|UniProtKB=P39656 P39656 DDOST PTHR10830:SF0 DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT biosynthetic process#GO:0009058;glycoprotein biosynthetic process#GO:0009101;protein N-linked glycosylation#GO:0006487;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100 oligosaccharyltransferase complex#GO:0008250;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;membrane protein complex#GO:0098796;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;membrane#GO:0016020;endoplasmic reticulum protein-containing complex#GO:0140534;organelle membrane#GO:0031090;transferase complex#GO:1990234;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 glycosyltransferase#PC00111;transferase#PC00220 HUMAN|HGNC=11017|UniProtKB=O15432 O15432 SLC31A2 PTHR12483:SF8 SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS PROTEIN SLC31A2 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;molecular function regulator activity#GO:0098772;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;transporter regulator activity#GO:0141108;transition metal ion transmembrane transporter activity#GO:0046915;monoatomic cation transmembrane transporter activity#GO:0008324 transition metal ion transport#GO:0000041;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;regulation of biological process#GO:0050789;regulation of transmembrane transport#GO:0034762;metal ion transport#GO:0030001;copper ion transmembrane transport#GO:0035434;regulation of metal ion transport#GO:0010959;regulation of cellular process#GO:0050794;transport#GO:0006810;regulation of monoatomic cation transmembrane transport#GO:1904062;regulation of transport#GO:0051049;regulation of localization#GO:0032879;establishment of localization#GO:0051234;cellular process#GO:0009987;regulation of monoatomic ion transmembrane transport#GO:0034765;biological regulation#GO:0065007;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;regulation of monoatomic ion transport#GO:0043269 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 HUMAN|HGNC=20992|UniProtKB=O75818 O75818 RPP40 PTHR15396:SF1 RIBONUCLEASE P PROTEIN SUBUNIT P40 RIBONUCLEASE P PROTEIN SUBUNIT P40 catalytic activity, acting on RNA#GO:0140098;RNA endonuclease activity#GO:0004521;endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;catalytic activity, acting on a tRNA#GO:0140101;nuclease activity#GO:0004518;ribonuclease P activity#GO:0004526 ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;maturation of 5.8S rRNA#GO:0000460;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;ribosomal small subunit biogenesis#GO:0042274;endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000447;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;tRNA processing#GO:0008033;cellular component biogenesis#GO:0044085;endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000479;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;maturation of SSU-rRNA#GO:0030490 multimeric ribonuclease P complex#GO:0030681;ribonuclease MRP complex#GO:0000172;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;ribonuclease P complex#GO:0030677;endoribonuclease complex#GO:1902555;endonuclease complex#GO:1905348;ribonucleoprotein complex#GO:1990904;intracellular protein-containing complex#GO:0140535;sno(s)RNA-containing ribonucleoprotein complex#GO:0005732 endoribonuclease#PC00094;RNA metabolism protein#PC00031 HUMAN|HGNC=25819|UniProtKB=Q9H8M1 Q9H8M1 COQ10B PTHR12901:SF9 SPERM PROTEIN HOMOLOG COENZYME Q-BINDING PROTEIN COQ10 HOMOLOG B, MITOCHONDRIAL intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HUMAN|HGNC=14111|UniProtKB=Q9HC38 Q9HC38 GLOD4 PTHR46466:SF1 GLYOXALASE DOMAIN-CONTAINING PROTEIN 4 GLYOXALASE DOMAIN-CONTAINING PROTEIN 4 HUMAN|HGNC=25576|UniProtKB=Q8IW45 Q8IW45 NAXD PTHR12592:SF0 ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE FAMILY MEMBER ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE hydro-lyase activity#GO:0016836;lyase activity#GO:0016829;carbon-oxygen lyase activity#GO:0016835;catalytic activity#GO:0003824 cellular process#GO:0009987;metabolic process#GO:0008152 metabolite interconversion enzyme#PC00262;dehydratase#PC00091 HUMAN|HGNC=11120|UniProtKB=P17405 P17405 SMPD1 PTHR10340:SF34 SPHINGOMYELIN PHOSPHODIESTERASE SPHINGOMYELIN PHOSPHODIESTERASE phosphoric diester hydrolase activity#GO:0008081;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity, acting on ester bonds#GO:0016788;phospholipase activity#GO:0120569;catalytic activity#GO:0003824;lipase activity#GO:0016298 ceramide metabolic process#GO:0006672;organophosphate catabolic process#GO:0046434;phospholipid metabolic process#GO:0006644;catabolic process#GO:0009056;phospholipid catabolic process#GO:0009395;sphingolipid catabolic process#GO:0030149;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;lipid metabolic process#GO:0006629;ceramide biosynthetic process#GO:0046513;sphingolipid biosynthetic process#GO:0030148;metabolic process#GO:0008152;sphingolipid metabolic process#GO:0006665;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;sphingomyelin metabolic process#GO:0006684;cellular process#GO:0009987;lipid catabolic process#GO:0016042;organophosphate metabolic process#GO:0019637 lysosome#GO:0005764;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vacuole#GO:0005773;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;extracellular region#GO:0005576;lytic vacuole#GO:0000323;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 hydrolase#PC00121;phosphodiesterase#PC00185 HUMAN|HGNC=6839|UniProtKB=P11137 P11137 MAP2 PTHR11501:SF15 MICROTUBULE-ASSOCIATED PROTEIN MICROTUBULE-ASSOCIATED PROTEIN 2 protein binding#GO:0005515;binding#GO:0005488;microtubule binding#GO:0008017;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092 anatomical structure development#GO:0048856;microtubule cytoskeleton organization#GO:0000226;neuron development#GO:0048666;system development#GO:0048731;regulation of microtubule-based process#GO:0032886;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of microtubule-based movement#GO:0060632;cell projection organization#GO:0030030;cell development#GO:0048468;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;microtubule-based process#GO:0007017;neurogenesis#GO:0022008;neuron differentiation#GO:0030182;developmental process#GO:0032502;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;nervous system development#GO:0007399;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;neuron projection development#GO:0031175;organelle organization#GO:0006996;cellular process#GO:0009987 neuronal cell body#GO:0043025;intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;somatodendritic compartment#GO:0036477;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell body#GO:0044297;neuron projection#GO:0043005;microtubule cytoskeleton#GO:0015630;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;axon#GO:0030424;cytoskeleton#GO:0005856 microtubule or microtubule-binding cytoskeletal protein#PC00157;non-motor microtubule binding protein#PC00166 HUMAN|HGNC=5172|UniProtKB=O43593 O43593 HR PTHR12549:SF4 JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROTEIN LYSINE-SPECIFIC DEMETHYLASE HAIRLESS transcription coregulator activity#GO:0003712;catalytic activity#GO:0003824;chromatin DNA binding#GO:0031490;histone demethylase activity#GO:0032452;protein demethylase activity#GO:0140457;demethylase activity#GO:0032451;catalytic activity, acting on a protein#GO:0140096;binding#GO:0005488;nucleic acid binding#GO:0003676;chromatin binding#GO:0003682;transcription regulator activity#GO:0140110;DNA binding#GO:0003677;histone modifying activity#GO:0140993 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;chromosome#GO:0005694;chromatin#GO:0000785;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232 histone modifying enzyme#PC00261 HUMAN|HGNC=1048|UniProtKB=Q9H2M3 Q9H2M3 BHMT2 PTHR46120:SF3 BETAINE--HOMOCYSTEINE S-METHYLTRANSFERASE 1 S-METHYLMETHIONINE--HOMOCYSTEINE S-METHYLTRANSFERASE BHMT2 transferase activity#GO:0016740;catalytic activity#GO:0003824;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741 proteinogenic amino acid metabolic process#GO:0170039;small molecule metabolic process#GO:0044281;amino acid metabolic process#GO:0006520;biosynthetic process#GO:0009058;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;sulfur compound metabolic process#GO:0006790;cellular process#GO:0009987;aspartate family amino acid biosynthetic process#GO:0009067;carboxylic acid biosynthetic process#GO:0046394;proteinogenic amino acid biosynthetic process#GO:0170038;amino acid biosynthetic process#GO:0008652;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;small molecule biosynthetic process#GO:0044283 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 methyltransferase#PC00155 HUMAN|HGNC=11629|UniProtKB=Q9Y242 Q9Y242 TCF19 PTHR15464:SF1 TRANSCRIPTION FACTOR 19 TRANSCRIPTION FACTOR 19 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 HUMAN|HGNC=1402|UniProtKB=Q08289 Q08289 CACNB2 PTHR11824:SF9 VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-2 trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;regulation of biological process#GO:0050789;cellular process#GO:0009987;synaptic signaling#GO:0099536;chemical synaptic transmission#GO:0007268;cell-cell signaling#GO:0007267;signaling#GO:0023052;biological regulation#GO:0065007;anterograde trans-synaptic signaling#GO:0098916 voltage-gated ion channel#PC00241 Thyrotropin-releasing hormone receptor signaling pathway#P04394>Ca2+ channel#P04587;Nicotinic acetylcholine receptor signaling pathway#P00044>Ca2+ channel#P01096;5HT2 type receptor mediated signaling pathway#P04374>Ca2+ channel#P04411;Alzheimer disease-amyloid secretase pathway#P00003>L-type calcium channels#P00082;Oxytocin receptor mediated signaling pathway#P04391>Ca2+ channel#P04535;Beta2 adrenergic receptor signaling pathway#P04378>Ca2+ channel#P04445;Beta1 adrenergic receptor signaling pathway#P04377>Ca2+ channel#P04438 HUMAN|HGNC=28527|UniProtKB=Q8N323 Q8N323 NXPE1 PTHR16165:SF42 NXPE FAMILY MEMBER NXPE FAMILY MEMBER 1 HUMAN|HGNC=4389|UniProtKB=P09471 P09471 GNAO1 PTHR10218:SF361 GTP-BINDING PROTEIN ALPHA SUBUNIT GUANINE NUCLEOTIDE-BINDING PROTEIN G(O) SUBUNIT ALPHA GTPase activity#GO:0003924;signaling receptor binding#GO:0005102;hormone receptor binding#GO:0051427;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;hydrolase activity#GO:0016787;protein binding#GO:0005515;hydrolase activity, acting on acid anhydrides#GO:0016817;G protein-coupled receptor binding#GO:0001664;pyrophosphatase activity#GO:0016462;neuropeptide receptor binding#GO:0071855;catalytic activity#GO:0003824;molecular function regulator activity#GO:0098772;ribonucleoside triphosphate phosphatase activity#GO:0017111 cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;cellular process#GO:0009987;G protein-coupled dopamine receptor signaling pathway#GO:0007212;biological regulation#GO:0065007;response to chemical#GO:0042221;cellular response to nitrogen compound#GO:1901699;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway#GO:0007193;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;response to oxygen-containing compound#GO:1901700;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;response to nitrogen compound#GO:1901698;cell communication#GO:0007154 catalytic complex#GO:1902494;extrinsic component of cytoplasmic side of plasma membrane#GO:0031234;side of membrane#GO:0098552;intracellular anatomical structure#GO:0005622;membrane protein complex#GO:0098796;cytoplasmic side of plasma membrane#GO:0009898;plasma membrane protein complex#GO:0098797;cellular anatomical structure#GO:0110165;cytoplasmic side of membrane#GO:0098562;extrinsic component of membrane#GO:0019898;extrinsic component of plasma membrane#GO:0019897;membrane#GO:0016020;cell periphery#GO:0071944;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;cytoplasm#GO:0005737 heterotrimeric G-protein#PC00117;G-protein#PC00020 5HT1 type receptor mediated signaling pathway#P04373>G-protein#P04408;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>G-Protein#P01085;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Goalpha#P00729;Endogenous cannabinoid signaling#P05730>Galpha#P05751;Opioid proopiomelanocortin pathway#P05917>G-protein#P06012;Gonadotropin-releasing hormone receptor pathway#P06664>gnai/o#P06773;Enkephalin release#P05913>G-Protein (i)#P05974;GABA-B receptor II signaling#P05731>Gi/oalpha#P05757;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Galphai#P00828;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Galphai/q#P00873;Opioid prodynorphin pathway#P05916>G-protein#P06002;Metabotropic glutamate receptor group II pathway#P00040>G-protein#P01047 HUMAN|HGNC=34242|UniProtKB=A8MTA8 A8MTA8 CIMIP2B PTHR22146:SF8 CAT EYE SYNDROME CRITICAL REGION PROTEIN 6 CILIARY MICROTUBULE INNER PROTEIN 2B HUMAN|HGNC=2911|UniProtKB=P36957 P36957 DLST PTHR43416:SF18 DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL catalytic activity, acting on a protein#GO:0140096;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740 tricarboxylic acid cycle#GO:0006099;primary metabolic process#GO:0044238;cellular process#GO:0009987;energy derivation by oxidation of organic compounds#GO:0015980;cellular respiration#GO:0045333;aerobic respiration#GO:0009060;metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739 transferase#PC00220 HUMAN|HGNC=10979|UniProtKB=P53007 P53007 SLC25A1 PTHR45788:SF4 SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED TRICARBOXYLATE TRANSPORT PROTEIN, MITOCHONDRIAL active transmembrane transporter activity#GO:0022804;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;citrate transmembrane transporter activity#GO:0015137 organic acid transport#GO:0015849;transport#GO:0006810;carboxylic acid transport#GO:0046942;tricarboxylic acid transport#GO:0006842;citrate transport#GO:0015746;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;cellular process#GO:0009987;carboxylic acid transmembrane transport#GO:1905039 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 transporter#PC00227 HUMAN|HGNC=14246|UniProtKB=Q9NPA2 Q9NPA2 MMP25 PTHR10201:SF142 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE-25 catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metalloendopeptidase activity#GO:0004222;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175 catabolic process#GO:0009056;cellular process#GO:0009987;cellular component organization#GO:0016043;external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;extracellular structure organization#GO:0043062;metabolic process#GO:0008152 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;extracellular region#GO:0005576;membrane#GO:0016020 metalloprotease#PC00153 Alzheimer disease-presenilin pathway#P00004>Matrix metalloprotease#P00130;Alzheimer disease-presenilin pathway#P00004>Membrane metalloprotease#P00141 HUMAN|HGNC=26572|UniProtKB=Q6P5X7 Q6P5X7 TMEM71 PTHR35255:SF1 TRANSMEMBRANE PROTEIN 71 TRANSMEMBRANE PROTEIN 71 HUMAN|HGNC=8142|UniProtKB=Q9H6K4 Q9H6K4 OPA3 PTHR12499:SF30 OPTIC ATROPHY 3 PROTEIN OPA3 OPTIC ATROPHY 3 PROTEIN neuromuscular process#GO:0050905;nervous system process#GO:0050877;multicellular organismal process#GO:0032501;system process#GO:0003008 mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=17686|UniProtKB=Q4ADV7 Q4ADV7 RIC1 PTHR22746:SF11 RAB6A-GEF COMPLEX PARTNER PROTEIN 1 GUANINE NUCLEOTIDE EXCHANGE FACTOR SUBUNIT RIC1 enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 neurogenesis#GO:0022008;intracellular protein localization#GO:0008104;neuron projection guidance#GO:0097485;cellular developmental process#GO:0048869;establishment of localization#GO:0051234;transport#GO:0006810;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;intracellular transport#GO:0046907;plasma membrane bounded cell projection organization#GO:0120036;multicellular organismal process#GO:0032501;axon development#GO:0061564;axon guidance#GO:0007411;retrograde transport, endosome to Golgi#GO:0042147;macromolecule localization#GO:0033036;system development#GO:0048731;anatomical structure development#GO:0048856;localization#GO:0051179;protein localization to cell junction#GO:1902414;endosomal transport#GO:0016197;cell projection morphogenesis#GO:0048858;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;protein localization to synapse#GO:0035418;plasma membrane bounded cell projection morphogenesis#GO:0120039;intracellular protein transport#GO:0006886;neuron differentiation#GO:0030182;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;neuron projection development#GO:0031175;protein transport#GO:0015031;axonogenesis#GO:0007409;neuron development#GO:0048666;cellular localization#GO:0051641;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;cytosolic transport#GO:0016482;cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;cell differentiation#GO:0030154;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043 organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;guanyl-nucleotide exchange factor complex#GO:0032045;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cytosol#GO:0005829;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 HUMAN|HGNC=24786|UniProtKB=Q5TZF3 Q5TZF3 ANKRD45 PTHR24180:SF14 CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 45 cellular process#GO:0009987;cell population proliferation#GO:0008283 midbody#GO:0030496;cellular anatomical structure#GO:0110165 kinase inhibitor#PC00139;kinase modulator#PC00140 HUMAN|HGNC=15746|UniProtKB=Q15785 Q15785 TOMM34 PTHR45984:SF2 RNA (RNA) POLYMERASE II ASSOCIATED PROTEIN HOMOLOG MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM34 binding#GO:0005488;heat shock protein binding#GO:0031072;protein binding#GO:0005515 protein localization to organelle#GO:0033365;localization#GO:0051179;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;protein localization to mitochondrion#GO:0070585 mitochondrion#GO:0005739;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=29830|UniProtKB=Q9H0A0 Q9H0A0 NAT10 PTHR10925:SF5 N-ACETYLTRANSFERASE 10 RNA CYTIDINE ACETYLTRANSFERASE catalytic activity, acting on a rRNA#GO:0140102;catalytic activity, acting on a tRNA#GO:0140101;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;transferase activity#GO:0016740 ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;tRNA wobble base modification#GO:0002097;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;rRNA modification#GO:0000154;RNA biosynthetic process#GO:0032774;tRNA modification#GO:0006400;ribonucleoprotein complex biogenesis#GO:0022613;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;rRNA metabolic process#GO:0016072;ribosomal small subunit biogenesis#GO:0042274;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;cellular component organization or biogenesis#GO:0071840;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;maturation of SSU-rRNA#GO:0030490;RNA processing#GO:0006396 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;preribosome#GO:0030684;ribonucleoprotein complex#GO:1990904;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;small-subunit processome#GO:0032040;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 RNA processing factor#PC00147 HUMAN|HGNC=5132|UniProtKB=Q9GZZ0 Q9GZZ0 HOXD1 PTHR45946:SF1 HOMEOBOX PROTEIN ROUGH-RELATED HOMEOBOX PROTEIN HOX-D1 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 HUMAN|HGNC=8856|UniProtKB=O75381 O75381 PEX14 PTHR23058:SF0 PEROXISOMAL MEMBRANE PROTEIN PEX14 PEROXISOMAL MEMBRANE PROTEIN PEX14 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 protein transport#GO:0015031;peroxisomal transport#GO:0043574;cellular localization#GO:0051641;transmembrane transport#GO:0055085;localization#GO:0051179;peroxisome organization#GO:0007031;protein import into peroxisome matrix#GO:0016558;protein localization to organelle#GO:0033365;cellular component organization#GO:0016043;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;intracellular protein transmembrane transport#GO:0065002;cellular component organization or biogenesis#GO:0071840;establishment of protein localization to organelle#GO:0072594;intracellular protein transport#GO:0006886;protein transmembrane transport#GO:0071806;transport#GO:0006810;protein transmembrane import into intracellular organelle#GO:0044743;intracellular transport#GO:0046907;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;macromolecule localization#GO:0033036;organelle organization#GO:0006996 microbody#GO:0042579;peroxisome#GO:0005777;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;peroxisomal membrane#GO:0005778;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;transporter complex#GO:1990351 primary active transporter#PC00068;transporter#PC00227 HUMAN|HGNC=8469|UniProtKB=Q8NGG7 Q8NGG7 OR8A1 PTHR48018:SF5 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 8A1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;sensory perception of smell#GO:0007608;signaling#GO:0023052;G protein-coupled receptor signaling pathway#GO:0007186;sensory perception#GO:0007600;nervous system process#GO:0050877;cell communication#GO:0007154;signal transduction#GO:0007165;cellular process#GO:0009987;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=28426|UniProtKB=Q96B36 Q96B36 AKT1S1 PTHR21844:SF2 AKT1 SUBSTRATE 1 PROTEIN PROLINE-RICH AKT1 SUBSTRATE 1 negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;negative regulation of TOR signaling#GO:0032007;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of TORC1 signaling#GO:1903432;negative regulation of cellular process#GO:0048523;negative regulation of TORC1 signaling#GO:1904262;regulation of response to stimulus#GO:0048583;negative regulation of response to stimulus#GO:0048585;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;regulation of TOR signaling#GO:0032006 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 CCKR signaling map#P06959>PRAS40#P07076 HUMAN|HGNC=3497|UniProtKB=P57679 P57679 EVC PTHR16795:SF13 LIMBIN/ELLIS-VAN CREVELD PROTEIN EVC COMPLEX MEMBER EVC cell surface receptor signaling pathway#GO:0007166;smoothened signaling pathway#GO:0007224;cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cilium#GO:0005929;cell projection membrane#GO:0031253;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;cell periphery#GO:0071944;protein-containing complex#GO:0032991;plasma membrane region#GO:0098590;ciliary membrane#GO:0060170;plasma membrane#GO:0005886;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090 HUMAN|HGNC=30807|UniProtKB=Q6UXN2 Q6UXN2 TREML4 PTHR16423:SF9 TREM-LIKE TRANSCRIPT PROTEIN TREM-LIKE TRANSCRIPT 4 PROTEIN molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 positive regulation of response to stimulus#GO:0048584;regulation of response to external stimulus#GO:0032101;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of immune system process#GO:0002684;positive regulation of pattern recognition receptor signaling pathway#GO:0062208;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of innate immune response#GO:0045089;regulation of innate immune response#GO:0045088;positive regulation of response to external stimulus#GO:0032103;positive regulation of response to biotic stimulus#GO:0002833;regulation of response to stress#GO:0080134;positive regulation of immune response#GO:0050778;positive regulation of defense response#GO:0031349;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;positive regulation of cell communication#GO:0010647;regulation of response to biotic stimulus#GO:0002831;regulation of cell communication#GO:0010646;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789;positive regulation of signaling#GO:0023056;regulation of intracellular signal transduction#GO:1902531;regulation of immune response#GO:0050776;regulation of defense response#GO:0031347;regulation of signaling#GO:0023051 cellular anatomical structure#GO:0110165;cell surface#GO:0009986 HUMAN|HGNC=12031|UniProtKB=Q13077 Q13077 TRAF1 PTHR10131:SF96 TNF RECEPTOR ASSOCIATED FACTOR TNF RECEPTOR-ASSOCIATED FACTOR 1 binding#GO:0005488;signaling receptor binding#GO:0005102;cytokine receptor binding#GO:0005126;protein-macromolecule adaptor activity#GO:0030674;signaling adaptor activity#GO:0035591;protein binding#GO:0005515;molecular adaptor activity#GO:0060090;tumor necrosis factor receptor superfamily binding#GO:0032813 regulation of intracellular signal transduction#GO:1902531;cytokine-mediated signaling pathway#GO:0019221;regulation of signaling#GO:0023051;tumor necrosis factor-mediated signaling pathway#GO:0033209;cell communication#GO:0007154;response to peptide#GO:1901652;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of cell communication#GO:0010646;signaling#GO:0023052;cell surface receptor signaling pathway#GO:0007166;regulation of response to stimulus#GO:0048583;response to tumor necrosis factor#GO:0034612;regulation of canonical NF-kappaB signal transduction#GO:0043122;cellular process#GO:0009987;signal transduction#GO:0007165;response to chemical#GO:0042221;response to cytokine#GO:0034097;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966 scaffold/adaptor protein#PC00226 HUMAN|HGNC=28237|UniProtKB=Q9HBR0 Q9HBR0 SLC38A10 PTHR22950:SF646 AMINO ACID TRANSPORTER SOLUTE CARRIER FAMILY 38 MEMBER 10 amino acid transmembrane transporter activity#GO:0015171;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;transporter activity#GO:0005215;L-amino acid transmembrane transporter activity#GO:0015179 amino acid transport#GO:0006865;transport#GO:0006810;cellular process#GO:0009987;transmembrane transport#GO:0055085;amino acid transmembrane transport#GO:0003333;establishment of localization#GO:0051234;localization#GO:0051179 membrane#GO:0016020;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258;amino acid transporter#PC00046 HUMAN|HGNC=10780|UniProtKB=Q07955 Q07955 SRSF1 PTHR23147:SF44 SERINE/ARGININE RICH SPLICING FACTOR SERINE_ARGININE-RICH SPLICING FACTOR 1 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;nuclear speck#GO:0016607;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;membraneless organelle#GO:0043228;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;intracellular membraneless organelle#GO:0043232;nuclear body#GO:0016604 RNA splicing factor#PC00148;RNA metabolism protein#PC00031;RNA processing factor#PC00147 HUMAN|HGNC=15916|UniProtKB=Q9P286 Q9P286 PAK5 PTHR48015:SF27 SERINE/THREONINE-PROTEIN KINASE TAO SERINE_THREONINE-PROTEIN KINASE PAK 5 protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096 regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;response to stress#GO:0006950;response to nutrient levels#GO:0031667;cellular process#GO:0009987;signal transduction#GO:0007165;cellular response to starvation#GO:0009267;regulation of response to stimulus#GO:0048583;regulation of MAPK cascade#GO:0043408;cellular response to nutrient levels#GO:0031669;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of cell communication#GO:0010646;signaling#GO:0023052;response to starvation#GO:0042594;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;cellular response to stress#GO:0033554 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Cytoskeletal regulation by Rho GTPase#P00016>PAK#P00517;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PAK#P00837 HUMAN|HGNC=20164|UniProtKB=Q8IX15 Q8IX15 HOMEZ PTHR15467:SF7 ZINC-FINGERS AND HOMEOBOXES RELATED HOMEOBOX AND LEUCINE ZIPPER PROTEIN HOMEZ DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 homeodomain transcription factor#PC00119;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=24045|UniProtKB=Q8NFR3 Q8NFR3 SPTSSB PTHR28612:SF1 SERINE PALMITOYLTRANSFERASE SMALL SUBUNIT B SERINE PALMITOYLTRANSFERASE SMALL SUBUNIT B acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740;palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 endoplasmic reticulum organization#GO:0007029;cellular process#GO:0009987;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;organelle organization#GO:0006996;endomembrane system organization#GO:0010256;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;lipid metabolic process#GO:0006629;ceramide biosynthetic process#GO:0046513;sphingolipid biosynthetic process#GO:0030148;metabolic process#GO:0008152;sphingolipid metabolic process#GO:0006665;ceramide metabolic process#GO:0006672;cellular component organization or biogenesis#GO:0071840 transferase complex#GO:1990234;catalytic complex#GO:1902494;protein-containing complex#GO:0032991 protein modifying enzyme#PC00260 HUMAN|HGNC=56768|UniProtKB=A0A0C4DGP1 A0A0C4DGP1 SMIM10L3 PTHR34446:SF1 SMALL INTEGRAL MEMBRANE PROTEIN 10 SMALL INTEGRAL MEMBRANE PROTEIN 10-LIKE PROTEIN 3 HUMAN|HGNC=26562|UniProtKB=Q5T1A1 Q5T1A1 DCST2 PTHR21041:SF6 DENDRITIC CELL-SPECIFIC TRANSMEMBRANE PROTEIN DC-STAMP DOMAIN-CONTAINING PROTEIN 2 cellular process#GO:0009987;single fertilization#GO:0007338;reproductive process#GO:0022414;fertilization#GO:0009566;sexual reproduction#GO:0019953;cell recognition#GO:0008037;sperm-egg recognition#GO:0035036;cell-cell recognition#GO:0009988 HUMAN|HGNC=20300|UniProtKB=O43482 O43482 OIP5 PTHR16431:SF3 NEUROGENIC PROTEIN MASTERMIND PROTEIN MIS18-BETA membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;cellular component assembly#GO:0022607;chromatin organization#GO:0006325;organelle assembly#GO:0070925;kinetochore assembly#GO:0051382;cellular component organization or biogenesis#GO:0071840;kinetochore organization#GO:0051383;chromosome organization#GO:0051276;protein-containing complex organization#GO:0043933 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694;chromatin#GO:0000785;nucleus#GO:0005634;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687;membrane-bounded organelle#GO:0043227;chromosome, centromeric region#GO:0000775;intracellular organelle#GO:0043229 HUMAN|HGNC=37207|UniProtKB=A6NFX1 A6NFX1 MFSD2B PTHR11328:SF30 MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN SPHINGOSINE-1-PHOSPHATE TRANSPORTER MFSD2B intramembrane lipid carrier activity#GO:0140303;lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104;transporter activity#GO:0005215 macromolecule localization#GO:0033036;cellular process#GO:0009987;lipid transport#GO:0006869;lipid localization#GO:0010876;transport#GO:0006810;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 primary active transporter#PC00068 HUMAN|HGNC=2172|UniProtKB=Q02246 Q02246 CNTN2 PTHR10075:SF55 BASIGIN RELATED CONTACTIN-2 cell adhesion molecule#PC00069 HUMAN|HGNC=2961|UniProtKB=Q14204 Q14204 DYNC1H1 PTHR10676:SF404 DYNEIN HEAVY CHAIN FAMILY PROTEIN CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1 ATP-dependent activity#GO:0140657;polypeptide conformation or assembly isomerase activity#GO:0120544;binding#GO:0005488;microtubule motor activity#GO:0003777;protein binding#GO:0005515;macromolecular conformation isomerase activity#GO:0120543;catalytic activity#GO:0003824;isomerase activity#GO:0016853;cytoskeletal motor activity#GO:0003774 cytoskeleton-dependent intracellular transport#GO:0030705;axo-dendritic transport#GO:0008088;spindle organization#GO:0007051;transport along microtubule#GO:0010970;establishment of localization#GO:0051234;mitotic cell cycle process#GO:1903047;intracellular transport#GO:0046907;transport#GO:0006810;mitotic cell cycle#GO:0000278;microtubule-based movement#GO:0007018;cell motility#GO:0048870;cell cycle#GO:0007049;microtubule cytoskeleton organization involved in mitosis#GO:1902850;nuclear migration#GO:0007097;localization#GO:0051179;microtubule cytoskeleton organization#GO:0000226;supramolecular fiber organization#GO:0097435;axonal transport#GO:0098930;organelle localization#GO:0051640;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cilium movement involved in cell motility#GO:0060294;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;cytoplasmic microtubule organization#GO:0031122;mitotic spindle organization#GO:0007052;establishment of organelle localization#GO:0051656;cellular component organization#GO:0016043;cell cycle process#GO:0022402;cilium-dependent cell motility#GO:0060285;cellular localization#GO:0051641;cilium movement#GO:0003341;microtubule-based transport#GO:0099111;cilium or flagellum-dependent cell motility#GO:0001539;retrograde axonal transport#GO:0008090 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;9+2 motile cilium#GO:0097729;cilium#GO:0005929;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;supramolecular fiber#GO:0099512;microtubule#GO:0005874;dynein complex#GO:0030286;cell cortex#GO:0005938;cytoplasmic microtubule#GO:0005881;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;motile cilium#GO:0031514;cytoskeleton#GO:0005856;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;cell periphery#GO:0071944;cytoplasmic dynein complex#GO:0005868;microtubule cytoskeleton#GO:0015630;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;microtubule associated complex#GO:0005875;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;supramolecular complex#GO:0099080 microtubule or microtubule-binding cytoskeletal protein#PC00157;microtubule binding motor protein#PC00156 Huntington disease#P00029>Dynein complex#P00774 HUMAN|HGNC=14922|UniProtKB=Q9HDD0 Q9HDD0 PLAAT1 PTHR13943:SF37 HRAS-LIKE SUPPRESSOR - RELATED PHOSPHOLIPASE A AND ACYLTRANSFERASE 1 acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;A2-type glycerophospholipase activity#GO:0004623;hydrolase activity, acting on ester bonds#GO:0016788;phospholipase activity#GO:0120569;catalytic activity#GO:0003824;transferase activity#GO:0016740;glycerophospholipase activity#GO:0004620;hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689;acyltransferase activity#GO:0016746;lipase activity#GO:0016298 organophosphate metabolic process#GO:0019637;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;cellular process#GO:0009987;glycerophospholipid metabolic process#GO:0006650;glycerolipid metabolic process#GO:0046486;phospholipid metabolic process#GO:0006644;metabolic process#GO:0008152;lipid metabolic process#GO:0006629 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 acyltransferase#PC00042;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=26344|UniProtKB=Q05D60 Q05D60 DEUP1 PTHR18875:SF5 SARCOMA ANTIGEN NY-SAR-24/CYTOSKELETAL PROTEIN SOJO DEUTEROSOME ASSEMBLY PROTEIN 1 cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cytoskeleton organization#GO:0007010;tissue development#GO:0009888;epithelial cell differentiation#GO:0030855;cellular component assembly#GO:0022607;epithelium development#GO:0060429;developmental process#GO:0032502;microtubule-based process#GO:0007017;centrosome duplication#GO:0051298;microtubule organizing center organization#GO:0031023;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;cell cycle process#GO:0022402;centrosome cycle#GO:0007098;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;cell cycle#GO:0007049;cell differentiation#GO:0030154;centriole replication#GO:0007099;animal gross anatomical part developmental process#GO:0160108;organelle assembly#GO:0070925;anatomical structure development#GO:0048856;microtubule cytoskeleton organization#GO:0000226 intracellular anatomical structure#GO:0005622;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;membraneless organelle#GO:0043228;organelle#GO:0043226;intracellular organelle#GO:0043229 cytoskeletal protein#PC00085 HUMAN|HGNC=9184|UniProtKB=Q9UGP5 Q9UGP5 POLL PTHR11276:SF28 DNA POLYMERASE TYPE-X FAMILY MEMBER DNA POLYMERASE LAMBDA catalytic activity, acting on a nucleic acid#GO:0140640;nucleotidyltransferase activity#GO:0016779;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on DNA#GO:0140097;DNA polymerase activity#GO:0034061;DNA-directed DNA polymerase activity#GO:0003887 DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA damage response#GO:0006974;cellular response to stress#GO:0033554;double-strand break repair via nonhomologous end joining#GO:0006303;macromolecule metabolic process#GO:0043170;double-strand break repair#GO:0006302;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139 DNA metabolism protein#PC00009;DNA-directed DNA polymerase#PC00018 HUMAN|HGNC=29597|UniProtKB=A1A4Y4 A1A4Y4 IRGM PTHR32341:SF9 INTERFERON-INDUCIBLE GTPASE IMMUNITY-RELATED GTPASE FAMILY M PROTEIN pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111 defense response to other organism#GO:0098542;cellular component assembly#GO:0022607;response to chemical#GO:0042221;response to cytokine#GO:0034097;autophagosome organization#GO:1905037;cellular process#GO:0009987;autophagy#GO:0006914;defense response to symbiont#GO:0140546;response to stress#GO:0006950;cellular component biogenesis#GO:0044085;response to biotic stimulus#GO:0009607;organelle organization#GO:0006996;autophagosome assembly#GO:0000045;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;cellular response to cytokine stimulus#GO:0071345;cellular component organization#GO:0016043;response to peptide#GO:1901652;process utilizing autophagic mechanism#GO:0061919;immune system process#GO:0002376;response to other organism#GO:0051707;macroautophagy#GO:0016236;immune response#GO:0006955;defense response#GO:0006952;response to external stimulus#GO:0009605;innate immune response#GO:0045087;response to external biotic stimulus#GO:0043207;catabolic process#GO:0009056;vacuole organization#GO:0007033;organelle assembly#GO:0070925 intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 HUMAN|HGNC=29286|UniProtKB=Q6UXK2 Q6UXK2 ISLR2 PTHR24366:SF15 IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS IMMUNOGLOBULIN SUPERFAMILY CONTAINING LEUCINE-RICH REPEAT PROTEIN 2 positive regulation of cellular component organization#GO:0051130;positive regulation of growth#GO:0045927;positive regulation of axonogenesis#GO:0050772;regulation of cell size#GO:0008361;regulation of biological quality#GO:0065008;regulation of cellular component size#GO:0032535;regulation of biological process#GO:0050789;regulation of multicellular organismal development#GO:2000026;positive regulation of multicellular organismal process#GO:0051240;cellular component organization#GO:0016043;positive regulation of nervous system development#GO:0051962;regulation of cellular component organization#GO:0051128;positive regulation of cell differentiation#GO:0045597;regulation of anatomical structure size#GO:0090066;regulation of axonogenesis#GO:0050770;cellular component organization or biogenesis#GO:0071840;regulation of anatomical structure morphogenesis#GO:0022603;positive regulation of cell growth#GO:0030307;positive regulation of biological process#GO:0048518;regulation of neuron projection development#GO:0010975;cellular process#GO:0009987;regulation of multicellular organismal process#GO:0051239;positive regulation of cell development#GO:0010720;regulation of cell growth#GO:0001558;positive regulation of cell projection organization#GO:0031346;regulation of nervous system development#GO:0051960;regulation of growth#GO:0040008;regulation of neurogenesis#GO:0050767;regulation of developmental process#GO:0050793;positive regulation of neurogenesis#GO:0050769;regulation of cellular process#GO:0050794;positive regulation of developmental process#GO:0051094;regulation of cell differentiation#GO:0045595;regulation of cell projection organization#GO:0031344;regulation of plasma membrane bounded cell projection organization#GO:0120035;positive regulation of cellular process#GO:0048522;regulation of cell development#GO:0060284;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;cell surface#GO:0009986 immunoglobulin superfamily cell adhesion molecule#PC00125 HUMAN|HGNC=23406|UniProtKB=Q9UPQ8 Q9UPQ8 DOLK PTHR13205:SF15 TRANSMEMBRANE PROTEIN 15-RELATED DOLICHOL KINASE kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;phosphotransferase activity, alcohol group as acceptor#GO:0016773 phospholipid biosynthetic process#GO:0008654;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;organophosphate metabolic process#GO:0019637;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;cellular process#GO:0009987;organophosphate biosynthetic process#GO:0090407;metabolic process#GO:0008152;lipid metabolic process#GO:0006629 membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=30134|UniProtKB=Q8IZL8 Q8IZL8 PELP1 PTHR34105:SF1 PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1 PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1 nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=16828|UniProtKB=Q9BRL7 Q9BRL7 SEC22C PTHR46258:SF2 LONGIN DOMAIN-CONTAINING PROTEIN VESICLE-TRAFFICKING PROTEIN SEC22C vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;transport#GO:0006810 HUMAN|HGNC=7076|UniProtKB=Q16674 Q16674 MIA PTHR47312:SF1 MELANOMA-DERIVED GROWTH REGULATORY PROTEIN MELANOMA-DERIVED GROWTH REGULATORY PROTEIN cellular component organization#GO:0016043;extracellular structure organization#GO:0043062;cellular process#GO:0009987;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;external encapsulating structure organization#GO:0045229 HUMAN|HGNC=23675|UniProtKB=Q5QJU3 Q5QJU3 ACER2 PTHR46139:SF1 ALKALINE CERAMIDASE ALKALINE CERAMIDASE 2 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810 sphingoid biosynthetic process#GO:0046520;ceramide metabolic process#GO:0006672;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;primary metabolic process#GO:0044238;sphingolipid catabolic process#GO:0030149;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;alcohol metabolic process#GO:0006066;sphingolipid biosynthetic process#GO:0030148;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;alcohol biosynthetic process#GO:0046165;lipid catabolic process#GO:0016042;cellular process#GO:0009987 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;intracellular organelle#GO:0043229;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794 HUMAN|Ensembl=ENSG00000288440.1|UniProtKB=A0AAG2TUN3 A0AAG2TUN3 GOLGA6L26 PTHR23143:SF31 TRICHOHYALIN-RELATED GOLGIN SUBFAMILY A MEMBER 6-LIKE PROTEIN 1-RELATED actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=34004|UniProtKB=A6NF01 A6NF01 POM121B PTHR23193:SF5 NUCLEAR PORE COMPLEX PROTEIN NUP NUCLEAR ENVELOPE PORE MEMBRANE PROTEIN POM 121C-RELATED structural constituent of nuclear pore#GO:0017056;structural molecule activity#GO:0005198;molecular carrier activity#GO:0140104;nucleocytoplasmic carrier activity#GO:0140142 nucleobase-containing compound transport#GO:0015931;RNA localization#GO:0006403;protein localization to organelle#GO:0033365;RNA transport#GO:0050658;establishment of RNA localization#GO:0051236;localization#GO:0051179;nucleic acid transport#GO:0050657;cellular localization#GO:0051641;nuclear transport#GO:0051169;protein import into nucleus#GO:0006606;protein transport#GO:0015031;nuclear export#GO:0051168;nucleocytoplasmic transport#GO:0006913;macromolecule localization#GO:0033036;import into nucleus#GO:0051170;nitrogen compound transport#GO:0071705;protein localization to nucleus#GO:0034504;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810 nucleus#GO:0005634;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear pore#GO:0005643;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 transporter#PC00227 HUMAN|HGNC=21061|UniProtKB=Q96JX3 Q96JX3 SERAC1 PTHR48182:SF2 PROTEIN SERAC1 PROTEIN SERAC1 HUMAN|HGNC=2149|UniProtKB=Q16280 Q16280 CNGA2 PTHR45638:SF3 CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A CYCLIC NUCLEOTIDE-GATED CHANNEL ALPHA-2 guanyl nucleotide binding#GO:0019001;gated channel activity#GO:0022836;binding#GO:0005488;nucleoside phosphate binding#GO:1901265;monoatomic cation transmembrane transporter activity#GO:0008324;guanyl ribonucleotide binding#GO:0032561;ribonucleotide binding#GO:0032553;transporter activity#GO:0005215;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;monoatomic ion channel activity#GO:0005216;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;monoatomic ion transmembrane transporter activity#GO:0015075;ligand-gated monoatomic ion channel activity#GO:0015276;small molecule binding#GO:0036094;anion binding#GO:0043168;ion binding#GO:0043167;channel activity#GO:0015267;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;nucleotide binding#GO:0000166;monoatomic cation channel activity#GO:0005261 cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;multicellular organismal process#GO:0032501;nervous system process#GO:0050877;transport#GO:0006810;sensory perception#GO:0007600;sensory perception of chemical stimulus#GO:0007606;monoatomic ion transport#GO:0006811;system process#GO:0003008;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812 cation channel complex#GO:0034703;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;cell periphery#GO:0071944;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane#GO:0005886;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 ion channel#PC00133;ligand-gated ion channel#PC00141 HUMAN|HGNC=8177|UniProtKB=P0DN82 P0DN82 OR12D1 PTHR26451:SF968 G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN OLFACTORY RECEPTOR 12D1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488 detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;sensory perception#GO:0007600;nervous system process#GO:0050877;system process#GO:0003008;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;detection of chemical stimulus#GO:0009593;response to chemical#GO:0042221;response to stimulus#GO:0050896;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501 membrane#GO:0016020;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021 HUMAN|HGNC=21269|UniProtKB=P59047 P59047 NLRP5 PTHR45690:SF7 NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12 NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 5 regulation of response to stress#GO:0080134;regulation of biological process#GO:0050789;regulation of inflammatory response#GO:0050727;regulation of defense response#GO:0031347;regulation of response to stimulus#GO:0048583;regulation of response to external stimulus#GO:0032101;biological regulation#GO:0065007 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cell periphery#GO:0071944;nucleus#GO:0005634;cell cortex#GO:0005938;mitochondrion#GO:0005739;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 defense/immunity protein#PC00090 HUMAN|HGNC=20885|UniProtKB=Q9NRZ5 Q9NRZ5 AGPAT4 PTHR10983:SF8 1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED 1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE DELTA catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 mitochondrion#GO:0005739;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;outer membrane#GO:0019867;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;membrane#GO:0016020;cytoplasm#GO:0005737;organelle outer membrane#GO:0031968;endomembrane system#GO:0012505;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;mitochondrial outer membrane#GO:0005741 transferase#PC00220;acyltransferase#PC00042 HUMAN|HGNC=11539|UniProtKB=Q15542 Q15542 TAF5 PTHR19879:SF4 TRANSCRIPTION INITIATION FACTOR TFIID TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5 protein complex scaffold activity#GO:0140378;structural molecule activity#GO:0005198 RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;DNA-templated transcription initiation#GO:0006352;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;macromolecule metabolic process#GO:0043170;transcription by RNA polymerase II#GO:0006366;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;transcription initiation at RNA polymerase II promoter#GO:0006367 transferase complex#GO:1990234;membraneless organelle#GO:0043228;transcription regulator complex#GO:0005667;intracellular protein-containing complex#GO:0140535;membrane-enclosed lumen#GO:0031974;RNA polymerase II transcription regulator complex#GO:0090575;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;peptidase complex#GO:1905368;catalytic complex#GO:1902494;SAGA-type complex#GO:0070461;RNA polymerase II, holoenzyme#GO:0016591;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;chromosome#GO:0005694;nuclear DNA-directed RNA polymerase complex#GO:0055029;intracellular membrane-bounded organelle#GO:0043231;nuclear protein-containing complex#GO:0140513;histone acetyltransferase complex#GO:0000123;SAGA complex#GO:0000124;chromatin#GO:0000785;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;transcription factor TFIID complex#GO:0005669;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;protein acetyltransferase complex#GO:0031248;acetyltransferase complex#GO:1902493;organelle lumen#GO:0043233;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165 HUMAN|HGNC=29317|UniProtKB=Q9HCJ2 Q9HCJ2 LRRC4C PTHR24369:SF8 ANTIGEN BSP, PUTATIVE-RELATED LEUCINE-RICH REPEAT-CONTAINING PROTEIN 4C protein binding#GO:0005515;cell-cell adhesion mediator activity#GO:0098632;binding#GO:0005488;cell adhesion mediator activity#GO:0098631;cell adhesion molecule binding#GO:0050839 regulation of cell projection organization#GO:0031344;regulation of plasma membrane bounded cell projection organization#GO:0120035;cellular component organization or biogenesis#GO:0071840;regulation of anatomical structure morphogenesis#GO:0022603;regulation of axonogenesis#GO:0050770;cell-cell adhesion#GO:0098609;regulation of neuron projection development#GO:0010975;cellular process#GO:0009987;regulation of trans-synaptic signaling#GO:0099177;biological regulation#GO:0065007;synapse organization#GO:0050808;cell adhesion#GO:0007155;regulation of signaling#GO:0023051;synaptic membrane adhesion#GO:0099560;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;cell junction organization#GO:0034330;regulation of developmental process#GO:0050793;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646 postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;glutamatergic synapse#GO:0098978;neuron to neuron synapse#GO:0098984;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;cell junction#GO:0030054;synaptic membrane#GO:0097060;asymmetric synapse#GO:0032279;organelle#GO:0043226;cellular anatomical structure#GO:0110165;synapse#GO:0045202;postsynapse#GO:0098794;postsynaptic density membrane#GO:0098839;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;postsynaptic density#GO:0014069 cell adhesion molecule#PC00069 HUMAN|HGNC=3546|UniProtKB=P00451 P00451 F8 PTHR24543:SF320 MULTICOPPER OXIDASE-RELATED COAGULATION FACTOR VIII metabolic process#GO:0008152;blood coagulation#GO:0007596;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;coagulation#GO:0050817;response to wounding#GO:0009611;response to stress#GO:0006950;biosynthetic process#GO:0009058;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;protein maturation#GO:0051604;gene expression#GO:0010467;blood coagulation, fibrin clot formation#GO:0072378;wound healing#GO:0042060;regulation of biological quality#GO:0065008;protein metabolic process#GO:0019538;protein activation cascade#GO:0072376;hemostasis#GO:0007599;primary metabolic process#GO:0044238;regulation of body fluid levels#GO:0050878;response to stimulus#GO:0050896 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 oxidoreductase#PC00176 Blood coagulation#P00011>FVIII#P00405;Blood coagulation#P00011>FVIIIa#P00446 HUMAN|HGNC=24446|UniProtKB=Q96FZ2 Q96FZ2 HMCES PTHR13604:SF1 DC12-RELATED ABASIC SITE PROCESSING PROTEIN HMCES DNA binding#GO:0003677;lyase activity#GO:0016829;single-stranded DNA binding#GO:0003697;damaged DNA binding#GO:0003684;nucleic acid binding#GO:0003676;binding#GO:0005488;catalytic activity#GO:0003824 double-strand break repair#GO:0006302;double-strand break repair via nonhomologous end joining#GO:0006303;multicellular organism development#GO:0007275;macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;developmental process#GO:0032502;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;interstrand cross-link repair#GO:0036297;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;multicellular organismal process#GO:0032501;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;response to stress#GO:0006950;system development#GO:0048731;anatomical structure development#GO:0048856;immune system development#GO:0002520;cellular response to stress#GO:0033554;animal gross anatomical part developmental process#GO:0160108;immune system process#GO:0002376;production of molecular mediator of immune response#GO:0002440;response to stimulus#GO:0050896;somatic diversification of immune receptors#GO:0002200;cellular response to stimulus#GO:0051716;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165;replication fork#GO:0005657;chromosome#GO:0005694;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229 HUMAN|HGNC=6944|UniProtKB=P49736 P49736 MCM2 PTHR11630:SF44 DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER DNA REPLICATION LICENSING FACTOR MCM2 catalytic activity#GO:0003824;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;macromolecular conformation isomerase activity#GO:0120543;helicase activity#GO:0004386;catalytic activity, acting on DNA#GO:0140097;3'-5' DNA helicase activity#GO:0043138;isomerase activity#GO:0016853;DNA helicase activity#GO:0003678;nucleic acid binding#GO:0003676;binding#GO:0005488;single-stranded DNA binding#GO:0003697;ATP-dependent activity#GO:0140657;DNA binding#GO:0003677;ATP-dependent activity, acting on DNA#GO:0008094 double-strand break repair via homologous recombination#GO:0000724;cell cycle process#GO:0022402;cellular response to stimulus#GO:0051716;DNA replication#GO:0006260;cell cycle#GO:0007049;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;response to stimulus#GO:0050896;mitotic cell cycle#GO:0000278;cellular response to stress#GO:0033554;recombinational repair#GO:0000725;DNA-templated DNA replication#GO:0006261;cellular process#GO:0009987;response to stress#GO:0006950;double-strand break repair via break-induced replication#GO:0000727;nucleobase-containing compound metabolic process#GO:0006139;DNA replication initiation#GO:0006270;DNA recombination#GO:0006310;DNA damage response#GO:0006974;cell cycle DNA replication#GO:0044786;DNA repair#GO:0006281;metabolic process#GO:0008152;mitotic DNA replication#GO:1902969;nuclear DNA replication#GO:0033260;DNA metabolic process#GO:0006259;mitotic cell cycle process#GO:1903047;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170 intracellular organelle#GO:0043229;MCM complex#GO:0042555;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 DNA metabolism protein#PC00009 HUMAN|HGNC=7680|UniProtKB=P52848 P52848 NDST1 PTHR10605:SF30 HEPARAN SULFATE SULFOTRANSFERASE BIFUNCTIONAL HEPARAN SULFATE N-DEACETYLASE_N-SULFOTRANSFERASE 1 transferase activity#GO:0016740;catalytic activity#GO:0003824;deacylase activity#GO:0160215;deacetylase activity#GO:0019213;sulfotransferase activity#GO:0008146;transferase activity, transferring sulphur-containing groups#GO:0016782 proteoglycan biosynthetic process#GO:0030166;biosynthetic process#GO:0009058;protein O-linked glycosylation#GO:0006493;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;proteoglycan metabolic process#GO:0006029;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 metabolite interconversion enzyme#PC00262;transferase#PC00220 HUMAN|HGNC=9245|UniProtKB=Q13136 Q13136 PPFIA1 PTHR12587:SF15 LAR INTERACTING PROTEIN LIP -RELATED PROTEIN LIPRIN-ALPHA-1 structural molecule activity#GO:0005198;protein complex scaffold activity#GO:0140378 cellular component organization or biogenesis#GO:0071840;cell junction organization#GO:0034330;synapse organization#GO:0050808;cellular process#GO:0009987;cellular component organization#GO:0016043 presynapse#GO:0098793;cell junction#GO:0030054;synapse#GO:0045202;cellular anatomical structure#GO:0110165;presynaptic active zone#GO:0048786 scaffold/adaptor protein#PC00226 HUMAN|HGNC=28471|UniProtKB=Q8WUJ1 Q8WUJ1 CYB5D2 PTHR10281:SF4 MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED NEUFERRICIN endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=9483|UniProtKB=P07478 P07478 PRSS2 PTHR24264:SF57 TRYPSIN-RELATED TRYPSIN-2 serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;serine-type peptidase activity#GO:0008236;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;catalytic activity#GO:0003824 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;primary metabolic process#GO:0044238;metabolic process#GO:0008152;proteolysis#GO:0006508 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 serine protease#PC00203;protease#PC00190 HUMAN|HGNC=15662|UniProtKB=Q9BS86 Q9BS86 ZPBP PTHR15443:SF5 ZONA PELLUCIDA BINDING PROTEIN SP38 ZONA PELLUCIDA-BINDING PROTEIN 1 spermatid differentiation#GO:0048515;acrosome assembly#GO:0001675;gamete generation#GO:0007276;cell differentiation#GO:0030154;fertilization#GO:0009566;cell development#GO:0048468;cellular process involved in reproduction in multicellular organism#GO:0022412;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cellular component organization or biogenesis#GO:0071840;anatomical structure formation involved in morphogenesis#GO:0048646;cell-cell recognition#GO:0009988;vesicle organization#GO:0016050;cellular anatomical entity morphogenesis#GO:0032989;cellular component assembly#GO:0022607;endomembrane system organization#GO:0010256;single fertilization#GO:0007338;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;binding of sperm to zona pellucida#GO:0007339;anatomical structure development#GO:0048856;multicellular organismal reproductive process#GO:0048609;cellular component assembly involved in morphogenesis#GO:0010927;organelle assembly#GO:0070925;cell recognition#GO:0008037;spermatid development#GO:0007286;sexual reproduction#GO:0019953;reproductive process#GO:0022414;developmental process involved in reproduction#GO:0003006;germ cell development#GO:0007281;cellular developmental process#GO:0048869;sperm-egg recognition#GO:0035036;spermatogenesis#GO:0007283;developmental process#GO:0032502;male gamete generation#GO:0048232 membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;acrosomal vesicle#GO:0001669;intracellular organelle#GO:0043229;organelle#GO:0043226;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular vesicle#GO:0097708;secretory vesicle#GO:0099503;vesicle#GO:0031982 HUMAN|HGNC=17356|UniProtKB=Q8IUX4 Q8IUX4 APOBEC3F PTHR13857:SF45 MRNA EDITING ENZYME DNA DC-DU-EDITING ENZYME APOBEC-3F nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;deaminase activity#GO:0019239 RNA modification#GO:0009451;RNA metabolic process#GO:0016070;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;base conversion or substitution editing#GO:0016553;defense response to virus#GO:0051607;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;negative regulation of metabolic process#GO:0009892;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;response to stress#GO:0006950;negative regulation of macromolecule biosynthetic process#GO:0010558;response to biotic stimulus#GO:0009607;cellular process#GO:0009987;macromolecule modification#GO:0043412;response to virus#GO:0009615;regulation of RNA metabolic process#GO:0051252;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cytidine to uridine editing#GO:0016554;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;response to external biotic stimulus#GO:0043207;negative regulation of cellular process#GO:0048523;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;defense response#GO:0006952;response to external stimulus#GO:0009605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;response to other organism#GO:0051707;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890 P-body#GO:0000932;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232 RNA processing factor#PC00147 HUMAN|HGNC=1956|UniProtKB=Q15822 Q15822 CHRNA2 PTHR18945:SF757 NEUROTRANSMITTER GATED ION CHANNEL NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-2 monoatomic cation transmembrane transporter activity#GO:0008324;postsynaptic neurotransmitter receptor activity#GO:0098960;gated channel activity#GO:0022836;transmembrane signaling receptor activity#GO:0004888;acetylcholine receptor activity#GO:0015464;signaling receptor activity#GO:0038023;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;transporter activity#GO:0005215;neurotransmitter receptor activity#GO:0030594;channel activity#GO:0015267;molecular transducer activity#GO:0060089;ligand-gated monoatomic ion channel activity#GO:0015276;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834 neuromuscular synaptic transmission#GO:0007274;regulation of membrane potential#GO:0042391;calcium ion transport#GO:0006816;synaptic signaling#GO:0099536;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;cellular process#GO:0009987;response to chemical#GO:0042221;regulation of trans-synaptic signaling#GO:0099177;cellular response to chemical stimulus#GO:0070887;response to oxygen-containing compound#GO:1901700;regulation of signaling#GO:0023051;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signaling#GO:0023052;transport#GO:0006810;establishment of localization#GO:0051234;synaptic transmission, cholinergic#GO:0007271;cellular response to nitrogen compound#GO:1901699;acetylcholine receptor signaling pathway#GO:0095500;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;monoatomic ion transmembrane transport#GO:0034220;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;localization#GO:0051179;monoatomic cation transport#GO:0006812;response to nitrogen compound#GO:1901698;chemical synaptic transmission#GO:0007268;cellular response to stimulus#GO:0051716;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;modulation of chemical synaptic transmission#GO:0050804;metal ion transport#GO:0030001;membrane depolarization#GO:0051899;regulation of cell communication#GO:0010646 membrane#GO:0016020;cell periphery#GO:0071944;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane region#GO:0098590;plasma membrane#GO:0005886;synaptic membrane#GO:0097060;signaling receptor complex#GO:0043235;transporter complex#GO:1990351;cell junction#GO:0030054;postsynapse#GO:0098794;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cellular anatomical structure#GO:0110165;synapse#GO:0045202;postsynaptic membrane#GO:0045211;transmembrane transporter complex#GO:1902495 ligand-gated ion channel#PC00141 Nicotinic acetylcholine receptor signaling pathway#P00044>alpha#P01088;Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086 HUMAN|HGNC=24865|UniProtKB=Q9HCL2 Q9HCL2 GPAM PTHR12563:SF16 GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE 1, MITOCHONDRIAL acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 glycerophospholipid metabolic process#GO:0006650;triglyceride biosynthetic process#GO:0019432;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058;organophosphate metabolic process#GO:0019637;glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987;neutral lipid metabolic process#GO:0006638;metabolic process#GO:0008152;acylglycerol metabolic process#GO:0006639;lipid metabolic process#GO:0006629;triglyceride metabolic process#GO:0006641;glycerolipid metabolic process#GO:0046486;phospholipid metabolic process#GO:0006644;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238 mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;acyltransferase#PC00042 HUMAN|HGNC=28924|UniProtKB=Q86Z20 Q86Z20 CCDC125 PTHR28616:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 125 COILED-COIL DOMAIN-CONTAINING PROTEIN 125 regulation of small GTPase mediated signal transduction#GO:0051056;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;negative regulation of signal transduction#GO:0009968;regulation of locomotion#GO:0040012;biological regulation#GO:0065007;negative regulation of locomotion#GO:0040013;regulation of signal transduction#GO:0009966;negative regulation of cell motility#GO:2000146;negative regulation of response to stimulus#GO:0048585;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;regulation of cell motility#GO:2000145;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;regulation of cell communication#GO:0010646;regulation of Rho protein signal transduction#GO:0035023;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=18189|UniProtKB=Q9NPD3 Q9NPD3 EXOSC4 PTHR11953:SF0 EXOSOME COMPLEX COMPONENT EXOSOME COMPLEX COMPONENT RRP41 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 macromolecule catabolic process#GO:0009057;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;RNA catabolic process#GO:0006401;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound catabolic process#GO:0034655;cellular process#GO:0009987;nucleic acid catabolic process#GO:0141188;catabolic process#GO:0009056;nucleobase-containing compound metabolic process#GO:0006139 catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 exoribonuclease#PC00099;RNA metabolism protein#PC00031 HUMAN|HGNC=28106|UniProtKB=Q5BJF2 Q5BJF2 TMEM97 PTHR31204:SF1 SIGMA INTRACELLULAR RECEPTOR 2 SIGMA INTRACELLULAR RECEPTOR 2 regulation of biological process#GO:0050789;regulation of localization#GO:0032879;regulation of transport#GO:0051049;biological regulation#GO:0065007;regulation of cellular process#GO:0050794 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 HUMAN|HGNC=23485|UniProtKB=Q8TE76 Q8TE76 MORC4 PTHR23336:SF22 ZINC FINGER CW-TYPE COILED-COIL DOMAIN PROTEIN 3. MORC FAMILY CW-TYPE ZINC FINGER PROTEIN 4 chromatin-protein adaptor activity#GO:0140463;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;histone H3 reader activity#GO:0140006;histone reader activity#GO:0140566 intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 HUMAN|HGNC=4722|UniProtKB=Q92522 Q92522 H1-10 PTHR11467:SF21 HISTONE H1 HISTONE H1.10 chromatin binding#GO:0003682;nucleic acid binding#GO:0003676;binding#GO:0005488;protein-containing complex binding#GO:0044877;double-stranded DNA binding#GO:0003690;nucleosome binding#GO:0031491;DNA binding#GO:0003677;chromatin DNA binding#GO:0031490 chromosome organization#GO:0051276;cellular component organization or biogenesis#GO:0071840;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;negative regulation of DNA metabolic process#GO:0051053;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;organelle organization#GO:0006996;regulation of metabolic process#GO:0019222;chromosome condensation#GO:0030261;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of DNA recombination#GO:0000018;negative regulation of metabolic process#GO:0009892;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of DNA metabolic process#GO:0051052;negative regulation of biological process#GO:0048519;negative regulation of DNA recombination#GO:0045910;cellular component organization#GO:0016043 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=14529|UniProtKB=Q6BEB4 Q6BEB4 SP5 PTHR23235:SF29 KRUEPPEL-LIKE TRANSCRIPTION FACTOR TRANSCRIPTION FACTOR SP5 double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=40|UniProtKB=P08183 P08183 ABCB1 PTHR24221:SF661 ATP-BINDING CASSETTE SUB-FAMILY B ATP-DEPENDENT TRANSLOCASE ABCB1 xenobiotic transmembrane transporter activity#GO:0042910;intramembrane lipid carrier activity#GO:0140303;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657;phosphatidylcholine intramembrane carrier activity#GO:0008525;molecular carrier activity#GO:0140104;lipid carrier activity#GO:0005319;primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804;ATPase-coupled intramembrane lipid carrier activity#GO:0140326;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 biological regulation#GO:0065007;membrane organization#GO:0061024;phospholipid transport#GO:0015914;phospholipid translocation#GO:0045332;lipid transport#GO:0006869;cellular process#GO:0009987;macromolecule localization#GO:0033036;nitrogen compound transport#GO:0071705;regulation of membrane lipid distribution#GO:0097035;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;transport#GO:0006810;lipid translocation#GO:0034204;ceramide transport#GO:0035627;organophosphate ester transport#GO:0015748;cellular component organization#GO:0016043;regulation of biological quality#GO:0065008;localization#GO:0051179;transmembrane transport#GO:0055085;lipid localization#GO:0010876 cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;plasma membrane#GO:0005886;membrane#GO:0016020;apical plasma membrane#GO:0016324;cell periphery#GO:0071944;apical part of cell#GO:0045177 ATP-binding cassette (ABC) transporter#PC00003 HUMAN|HGNC=30696|UniProtKB=Q8NI36 Q8NI36 WDR36 PTHR22840:SF12 WD REPEAT-CONTAINING PROTEIN 36 WD REPEAT-CONTAINING PROTEIN 36 macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;ribosomal small subunit biogenesis#GO:0042274;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 intracellular organelle#GO:0043229;preribosome#GO:0030684;ribonucleoprotein complex#GO:1990904;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;small-subunit processome#GO:0032040;organelle lumen#GO:0043233;90S preribosome#GO:0030686;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991 HUMAN|HGNC=10075|UniProtKB=O43148 O43148 RNMT PTHR12189:SF2 MRNA GUANINE-7- METHYLTRANSFERASE MRNA CAP GUANINE-N(7) METHYLTRANSFERASE transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on RNA#GO:0140098;RNA methyltransferase activity#GO:0008173;N-methyltransferase activity#GO:0008170;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 RNA methyltransferase#PC00033 HUMAN|HGNC=11231|UniProtKB=Q8WXF7 Q8WXF7 ATL1 PTHR10751:SF15 GUANYLATE BINDING PROTEIN ATLASTIN-1 pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111 organelle organization#GO:0006996;cellular component organization#GO:0016043;endoplasmic reticulum organization#GO:0007029;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;endomembrane system organization#GO:0010256 G-protein#PC00020;heterotrimeric G-protein#PC00117 HUMAN|HGNC=6876|UniProtKB=Q16539 Q16539 MAPK14 PTHR24055:SF110 MITOGEN-ACTIVATED PROTEIN KINASE MITOGEN-ACTIVATED PROTEIN KINASE 14 transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 FGF signaling pathway#P00021>p38#P00644;EGF receptor signaling pathway#P00018>p38#P00562;B cell activation#P00010>p38#P00384;TGF-beta signaling pathway#P00052>P38#P01275;Gonadotropin-releasing hormone receptor pathway#P06664>p38#P06831;VEGF signaling pathway#P00056>p38MAPK#P01423;JAK/STAT signaling pathway#P00038>Serine kinase#P01029;Parkinson disease#P00049>p38 MAPK#P01212;p53 pathway feedback loops 2#P04398>p38 MAPK#P04648;Oxidative stress response#P00046>p38#P01135;p38 MAPK pathway#P05918>p38alpha#P06031;CCKR signaling map#P06959>p38MAPK#P07079;Toll receptor signaling pathway#P00054>p38#P01352;Angiogenesis#P00005>p38MAPK#P00182;Alzheimer disease-amyloid secretase pathway#P00003>MAPK#P00099;Interferon-gamma signaling pathway#P00035>Serine kinase#P00955;CCKR signaling map#P06959>MAPKAP-K2#P07217;Ras Pathway#P04393>p38#P04558 HUMAN|HGNC=7723|UniProtKB=Q8NHV4 Q8NHV4 NEDD1 PTHR44414:SF1 PROTEIN NEDD1 PROTEIN NEDD1 protein binding#GO:0005515;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631 microtubule cytoskeleton organization#GO:0000226;supramolecular fiber organization#GO:0097435;cellular component organization#GO:0016043;cell cycle#GO:0007049;microtubule nucleation#GO:0007020;protein-containing complex assembly#GO:0065003;protein polymerization#GO:0051258;mitotic cell cycle#GO:0000278;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;microtubule-based process#GO:0007017;microtubule polymerization#GO:0046785;microtubule polymerization or depolymerization#GO:0031109;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010 membraneless organelle#GO:0043228;spindle#GO:0005819;microtubule organizing center#GO:0005815;centrosome#GO:0005813;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;centriole#GO:0005814;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cilium#GO:0005929;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;spindle pole#GO:0000922 HUMAN|HGNC=19907|UniProtKB=Q712K3 Q712K3 UBE2R2 PTHR24067:SF148 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2 R2 acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-like protein conjugating enzyme activity#GO:0061650;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin conjugating enzyme activity#GO:0061631;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 primary metabolic process#GO:0044238;protein modification process#GO:0036211;modification-dependent protein catabolic process#GO:0019941;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;catabolic process#GO:0009056;protein modification by small protein conjugation or removal#GO:0070647;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;cellular process#GO:0009987;post-translational protein modification#GO:0043687;proteasomal protein catabolic process#GO:0010498;protein ubiquitination#GO:0016567;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;protein K48-linked ubiquitination#GO:0070936;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=546|UniProtKB=P13928 P13928 ANXA8 PTHR10502:SF133 ANNEXIN ANNEXIN A8-RELATED ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;phospholipid binding#GO:0005543;binding#GO:0005488;lipid binding#GO:0008289;phosphatidylserine binding#GO:0001786 cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;endomembrane system organization#GO:0010256;intracellular transport#GO:0046907;transport#GO:0006810;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;endosome organization#GO:0007032;vesicle organization#GO:0016050;endosomal transport#GO:0016197 membrane#GO:0016020;vesicle membrane#GO:0012506;nucleus#GO:0005634;cell periphery#GO:0071944;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;plasma membrane#GO:0005886;intracellular organelle#GO:0043229;sarcolemma#GO:0042383;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 calcium-binding protein#PC00060 HUMAN|HGNC=7817|UniProtKB=Q02575 Q02575 NHLH1 PTHR13864:SF20 T-CELL ACUTE LYMPHOCYTIC LEUKEMIA/STEM CELL LEUKEMIA-RELATED HELIX-LOOP-HELIX PROTEIN 1 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=28300|UniProtKB=Q969T7 Q969T7 NT5C3B PTHR13045:SF15 5'-NUCLEOTIDASE 7-METHYLGUANOSINE PHOSPHATE-SPECIFIC 5'-NUCLEOTIDASE phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;5'-nucleotidase activity#GO:0008253;nucleotidase activity#GO:0008252;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 esterase#PC00097;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=27981|UniProtKB=Q8NEM8 Q8NEM8 AGBL3 PTHR12756:SF23 CYTOSOLIC CARBOXYPEPTIDASE CYTOSOLIC CARBOXYPEPTIDASE 3 carboxypeptidase activity#GO:0004180;protein binding#GO:0005515;hydrolase activity#GO:0016787;metallocarboxypeptidase activity#GO:0004181;exopeptidase activity#GO:0008238;metallopeptidase activity#GO:0008237;binding#GO:0005488;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;cytoskeletal protein binding#GO:0008092;metalloexopeptidase activity#GO:0008235;tubulin binding#GO:0015631;catalytic activity#GO:0003824 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;cytoplasm#GO:0005737;centriole#GO:0005814;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;microtubule cytoskeleton#GO:0015630 metalloprotease#PC00153 HUMAN|HGNC=7061|UniProtKB=P10620 P10620 MGST1 PTHR10689:SF11 MICROSOMAL GLUTATHIONE S-TRANSFERASE 1 MICROSOMAL GLUTATHIONE S-TRANSFERASE 1 transferase activity#GO:0016740;glutathione transferase activity#GO:0004364;catalytic activity#GO:0003824;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 metabolite interconversion enzyme#PC00262;transferase#PC00220 HUMAN|HGNC=20708|UniProtKB=O95704 O95704 APBB3 PTHR14058:SF10 AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B AMYLOID-BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 3 binding#GO:0005488;peptide binding#GO:0042277 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 Alzheimer disease-presenilin pathway#P00004>Fe65#P00126 HUMAN|HGNC=9229|UniProtKB=O14495 O14495 PLPP3 PTHR10165:SF79 LIPID PHOSPHATE PHOSPHATASE PHOSPHOLIPID PHOSPHATASE 3 catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578 biological regulation#GO:0065007;signal transduction#GO:0007165;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;cell-cell adhesion#GO:0098609;lipid modification#GO:0030258;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;phospholipid metabolic process#GO:0006644;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;phospholipid dephosphorylation#GO:0046839;regulation of biological process#GO:0050789;phosphate-containing compound metabolic process#GO:0006796;cellular response to stimulus#GO:0051716;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;dephosphorylation#GO:0016311;cell communication#GO:0007154;cell adhesion#GO:0007155 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 hydrolase#PC00121;phosphatase#PC00181 HUMAN|HGNC=13060|UniProtKB=Q14586 Q14586 ZNF267 PTHR24376:SF88 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 267 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=24605|UniProtKB=Q96K83 Q96K83 ZNF521 PTHR24376:SF84 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 521 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=17427|UniProtKB=Q92784 Q92784 DPF3 PTHR23057:SF4 JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1 ZINC FINGER PROTEIN DPF3 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=27989|UniProtKB=Q5JQF8 Q5JQF8 PABPC1L2A PTHR24012:SF848 RNA BINDING PROTEIN POLYADENYLATE-BINDING PROTEIN 1-LIKE 2 mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;poly(A) binding#GO:0008143;single-stranded RNA binding#GO:0003727;mRNA 3'-UTR binding#GO:0003730;RNA binding#GO:0003723 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;post-transcriptional regulation of gene expression#GO:0010608;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;protein-containing complex#GO:0032991;nucleus#GO:0005634;cytosol#GO:0005829;cytoplasmic stress granule#GO:0010494;membraneless organelle#GO:0043228 RNA metabolism protein#PC00031 HUMAN|HGNC=3446|UniProtKB=P11308 P11308 ERG PTHR11849:SF216 ETS TRANSCRIPTIONAL REGULATOR ERG transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;developmental process#GO:0032502;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;cellular process#GO:0009987;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 winged helix/forkhead transcription factor#PC00246;DNA-binding transcription factor#PC00218 PDGF signaling pathway#P00047>Ets#P01167 HUMAN|HGNC=26178|UniProtKB=Q2V2M9 Q2V2M9 FHOD3 PTHR45920:SF3 FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I FH1_FH2 DOMAIN-CONTAINING PROTEIN 3 protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;actin filament binding#GO:0051015;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092 animal organ development#GO:0048513;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;anatomical structure formation involved in morphogenesis#GO:0048646;striated muscle cell differentiation#GO:0051146;cellular anatomical entity morphogenesis#GO:0032989;striated muscle tissue development#GO:0014706;positive regulation of cellular component biogenesis#GO:0044089;cellular component assembly#GO:0022607;heart development#GO:0007507;regulation of actin cytoskeleton organization#GO:0032956;cardiac muscle cell differentiation#GO:0055007;cytoskeleton organization#GO:0007010;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of organelle organization#GO:0010638;striated muscle cell development#GO:0055002;animal gross anatomical part developmental process#GO:0160108;positive regulation of cellular component organization#GO:0051130;regulation of cellular component organization#GO:0051128;cell differentiation#GO:0030154;circulatory system development#GO:0072359;cell development#GO:0048468;regulation of cellular component biogenesis#GO:0044087;actomyosin structure organization#GO:0031032;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;regulation of actin filament bundle assembly#GO:0032231;regulation of organelle organization#GO:0033043;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cellular developmental process#GO:0048869;cardiac muscle tissue development#GO:0048738;actin filament organization#GO:0007015;positive regulation of actin filament bundle assembly#GO:0032233;regulation of actin filament-based process#GO:0032970;developmental process#GO:0032502;multicellular organismal process#GO:0032501;tissue development#GO:0009888;biological regulation#GO:0065007;regulation of actin filament organization#GO:0110053;positive regulation of cellular process#GO:0048522;anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;system development#GO:0048731;muscle tissue development#GO:0060537;cellular component assembly involved in morphogenesis#GO:0010927;organelle assembly#GO:0070925;actin filament-based process#GO:0030029;sarcomere organization#GO:0045214;muscle structure development#GO:0061061;regulation of cellular process#GO:0050794;actin cytoskeleton organization#GO:0030036;regulation of cytoskeleton organization#GO:0051493;regulation of stress fiber assembly#GO:0051492;muscle cell development#GO:0055001;myofibril assembly#GO:0030239;muscle cell differentiation#GO:0042692;regulation of supramolecular fiber organization#GO:1902903 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737 HUMAN|HGNC=12125|UniProtKB=A0A087WT01 A0A087WT01 TRAV27 PTHR19433:SF136 T-CELL RECEPTOR ALPHA CHAIN V REGION-RELATED T CELL RECEPTOR ALPHA VARIABLE 27 response to stimulus#GO:0050896;response to external stimulus#GO:0009605;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to other organism#GO:0051707;response to biotic stimulus#GO:0009607;response to bacterium#GO:0009617 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=20604|UniProtKB=Q9Y2L1 Q9Y2L1 DIS3 PTHR23355:SF35 RIBONUCLEASE EXOSOME COMPLEX EXONUCLEASE RRP44 catalytic activity, acting on RNA#GO:0140098;3'-5' exonuclease activity#GO:0008408;endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;nuclease activity#GO:0004518;exonuclease activity#GO:0004527;3'-5'-RNA exonuclease activity#GO:0000175 regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;rRNA metabolic process#GO:0016072;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;nuclear mRNA surveillance#GO:0071028;negative regulation of macromolecule metabolic process#GO:0010605;nucleic acid catabolic process#GO:0141188;nucleobase-containing compound catabolic process#GO:0034655;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;cellular process#GO:0009987;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;RNA metabolic process#GO:0016070;RNA catabolic process#GO:0006401;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013 exoribonuclease#PC00099 HUMAN|HGNC=16833|UniProtKB=O14544 O14544 SOCS6 PTHR10155:SF32 PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT SUPPRESSOR OF CYTOKINE SIGNALING 6 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;signaling adaptor activity#GO:0035591 kinase modulator#PC00140 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>SOCS#P00879;Interferon-gamma signaling pathway#P00035>SOCS#P00956 HUMAN|HGNC=28705|UniProtKB=Q8N5W9 Q8N5W9 RFLNB PTHR31848:SF2 REFILIN-A-RELATED REFILIN-B skeletal system morphogenesis#GO:0048705;regulation of cell development#GO:0060284;multicellular organismal process#GO:0032501;regulation of bone mineralization#GO:0030500;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;regulation of cell differentiation#GO:0045595;developmental process#GO:0032502;animal organ development#GO:0048513;multicellular organism development#GO:0007275;negative regulation of biological process#GO:0048519;negative regulation of multicellular organismal process#GO:0051241;regulation of multicellular organismal development#GO:2000026;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;animal organ morphogenesis#GO:0009887;regulation of developmental process#GO:0050793;animal gross anatomical part developmental process#GO:0160108;anatomical structure development#GO:0048856;skeletal system development#GO:0001501;system development#GO:0048731 HUMAN|HGNC=798|UniProtKB=O00244 O00244 ATOX1 PTHR46365:SF1 COPPER TRANSPORT PROTEIN ATOX1 COPPER TRANSPORT PROTEIN ATOX1 molecular carrier activity#GO:0140104 primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 HUMAN|HGNC=16952|UniProtKB=Q9H3M7 Q9H3M7 TXNIP PTHR11188:SF14 ARRESTIN DOMAIN CONTAINING PROTEIN THIOREDOXIN-INTERACTING PROTEIN enzyme inhibitor activity#GO:0004857;molecular function inhibitor activity#GO:0140678;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234 response to stimulus#GO:0050896;response to oxidative stress#GO:0006979;response to stress#GO:0006950 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=25752|UniProtKB=Q96QE3 Q96QE3 ATAD5 PTHR23389:SF21 CHROMOSOME TRANSMISSION FIDELITY FACTOR 18 ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 5 ATP-dependent activity#GO:0140657;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA binding#GO:0003677;ATP-dependent activity, acting on DNA#GO:0008094;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on DNA#GO:0140097 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 DNA metabolism protein#PC00009 HUMAN|HGNC=14516|UniProtKB=Q9Y676 Q9Y676 MRPS18B PTHR13329:SF2 MITOCHONDRIAL RIBOSOMAL PROTEIN S18B SMALL RIBOSOMAL SUBUNIT PROTEIN MS40 intracellular anatomical structure#GO:0005622;organellar ribosome#GO:0000313;mitochondrial ribosome#GO:0005761;membrane-bounded organelle#GO:0043227;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;small ribosomal subunit#GO:0015935;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;mitochondrion#GO:0005739;organelle lumen#GO:0043233;membraneless organelle#GO:0043228;mitochondrial small ribosomal subunit#GO:0005763;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;membrane-enclosed lumen#GO:0031974 ribosomal protein#PC00202 HUMAN|HGNC=21378|UniProtKB=Q5TC84 Q5TC84 OGFRL1 PTHR14015:SF0 OPIOID GROWTH FACTOR RECEPTOR OGFR ZETA-TYPE OPIOID RECEPTOR OPIOID GROWTH FACTOR RECEPTOR-LIKE PROTEIN 1 transmembrane signal receptor#PC00197 HUMAN|HGNC=495|UniProtKB=Q9GZV1 Q9GZV1 ANKRD2 PTHR24126:SF3 ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 2 protein binding#GO:0005515;RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629;DNA-binding transcription factor binding#GO:0140297;binding#GO:0005488;transcription factor binding#GO:0008134 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=1027|UniProtKB=Q02338 Q02338 BDH1 PTHR43313:SF25 SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C D-BETA-HYDROXYBUTYRATE DEHYDROGENASE, MITOCHONDRIAL oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 mitochondrial inner membrane#GO:0005743;organelle envelope#GO:0031967;membrane#GO:0016020;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=7780|UniProtKB=Q16621 Q16621 NFE2 PTHR24411:SF26 NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR TRANSCRIPTION FACTOR NF-E2 45 KDA SUBUNIT cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 basic leucine zipper transcription factor#PC00056 HUMAN|HGNC=1605|UniProtKB=P51679 P51679 CCR4 PTHR10489:SF608 CELL ADHESION MOLECULE C-C CHEMOKINE RECEPTOR TYPE 4 cytokine receptor activity#GO:0004896;G protein-coupled receptor activity#GO:0004930;immune receptor activity#GO:0140375;signaling receptor activity#GO:0038023;cytokine binding#GO:0019955;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;protein binding#GO:0005515 regulation of biological quality#GO:0065008;intracellular signal transduction#GO:0035556;cell chemotaxis#GO:0060326;cell communication#GO:0007154;chemotaxis#GO:0006935;immune system process#GO:0002376;positive regulation of cytosolic calcium ion concentration#GO:0007204;cellular response to chemical stimulus#GO:0070887;locomotion#GO:0040011;signaling#GO:0023052;cell motility#GO:0048870;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;calcium-mediated signaling#GO:0019722;response to external stimulus#GO:0009605;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;cell migration#GO:0016477;response to chemical#GO:0042221;taxis#GO:0042330;cellular process#GO:0009987;immune response#GO:0006955;signal transduction#GO:0007165 cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020;plasma membrane#GO:0005886;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552 cell adhesion molecule#PC00069 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CHKR#P00854 HUMAN|HGNC=22938|UniProtKB=P59046 P59046 NLRP12 PTHR45690:SF11 NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12 NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12 regulation of non-canonical NF-kappaB signal transduction#GO:1901222;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of intracellular signal transduction#GO:1902532;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;negative regulation of cell communication#GO:0010648;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;regulation of response to external stimulus#GO:0032101;positive regulation of macromolecule metabolic process#GO:0010604;negative regulation of signal transduction#GO:0009968;positive regulation of biological process#GO:0048518;regulation of cellular process#GO:0050794;negative regulation of canonical NF-kappaB signal transduction#GO:0043124;regulation of macromolecule metabolic process#GO:0060255;regulation of cell communication#GO:0010646;positive regulation of biosynthetic process#GO:0009891;regulation of defense response#GO:0031347;regulation of inflammatory response#GO:0050727;negative regulation of response to stimulus#GO:0048585;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of canonical NF-kappaB signal transduction#GO:0043122;positive regulation of cellular process#GO:0048522;regulation of biosynthetic process#GO:0009889;negative regulation of cellular process#GO:0048523;regulation of response to stress#GO:0080134;regulation of response to stimulus#GO:0048583 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 defense/immunity protein#PC00090 HUMAN|HGNC=2638|UniProtKB=P20815 P20815 CYP3A5 PTHR24302:SF38 CYTOCHROME P450 FAMILY 3 CYTOCHROME P450 3A5 monooxygenase activity#GO:0004497;catalytic activity#GO:0003824;steroid hydroxylase activity#GO:0008395;oxidoreductase activity#GO:0016491 steroid metabolic process#GO:0008202;metabolic process#GO:0008152;primary metabolic process#GO:0044238;cellular process#GO:0009987;lipid metabolic process#GO:0006629 oxygenase#PC00177;oxidoreductase#PC00176 HUMAN|HGNC=9401|UniProtKB=Q02156 Q02156 PRKCE PTHR24356:SF159 SERINE/THREONINE-PROTEIN KINASE PROTEIN KINASE C EPSILON TYPE protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 non-receptor serine/threonine protein kinase#PC00167 Gonadotropin-releasing hormone receptor pathway#P06664>PKCs(3)#P06850;5HT2 type receptor mediated signaling pathway#P04374>PKC#P04420;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>PKC#P00745;Alzheimer disease-amyloid secretase pathway#P00003>PKC#P00109;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>PKC#P01074;Gonadotropin-releasing hormone receptor pathway#P06664>PKCs#P06733;CCKR signaling map#P06959>PKCepsilon#P07054;Apoptosis signaling pathway#P00006>PKCs#P00318;Alpha adrenergic receptor signaling pathway#P00002>PKC#P00075;Gonadotropin-releasing hormone receptor pathway#P06664>nPKCs#P06852;Endothelin signaling pathway#P00019>PKC#P00568;FGF signaling pathway#P00021>PKC#P00648;Thyrotropin-releasing hormone receptor signaling pathway#P04394>PKC#P04583;Oxytocin receptor mediated signaling pathway#P04391>PKC#P04533;Wnt signaling pathway#P00057>Protein Kinase C#P01458;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PKC#P00861;Gonadotropin-releasing hormone receptor pathway#P06664>PKCe/theta#P06798;Histamine H1 receptor mediated signaling pathway#P04385>PKC#P04487;EGF receptor signaling pathway#P00018>PKC#P00565;VEGF signaling pathway#P00056>PKC#P01425;Angiogenesis#P00005>PKC#P00219 HUMAN|HGNC=5888|UniProtKB=P01704 P01704 IGLV2-14 PTHR23267:SF407 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN LAMBDA VARIABLE 2-14-RELATED immune response#GO:0006955;immune system process#GO:0002376;response to stimulus#GO:0050896 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=8618|UniProtKB=O43316 O43316 PAX4 PTHR45636:SF8 PAIRED BOX PROTEIN PAX-6-RELATED-RELATED PAIRED BOX PROTEIN PAX-4 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;animal gross anatomical part developmental process#GO:0160108;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;central nervous system development#GO:0007417;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of gene expression#GO:0010468;multicellular organism development#GO:0007275;regulation of biosynthetic process#GO:0009889;animal organ development#GO:0048513;developmental process#GO:0032502;sensory organ development#GO:0007423;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;head development#GO:0060322;nervous system development#GO:0007399;brain development#GO:0007420;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=16036|UniProtKB=Q9P0S3 Q9P0S3 ORMDL1 PTHR12665:SF12 ORMDL PROTEINS ORM1-LIKE PROTEIN 1 cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;ceramide metabolic process#GO:0006672;lipid metabolic process#GO:0006629;chemical homeostasis#GO:0048878;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;homeostatic process#GO:0042592;cellular process#GO:0009987;primary metabolic process#GO:0044238;lipid homeostasis#GO:0055088 catalytic complex#GO:1902494;transferase complex#GO:1990234;protein-containing complex#GO:0032991 HUMAN|HGNC=4318|UniProtKB=P10070 P10070 GLI2 PTHR45718:SF6 TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS TRANSCRIPTION ACTIVATOR GLI2 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;signaling#GO:0023052;regulation of macromolecule metabolic process#GO:0060255;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;smoothened signaling pathway#GO:0007224;regulation of RNA metabolic process#GO:0051252;cell communication#GO:0007154;regulation of DNA-templated transcription#GO:0006355;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;cell surface receptor signaling pathway#GO:0007166;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 Hedgehog signaling pathway#P00025>Cubitus interruptus#P00690 HUMAN|HGNC=9340|UniProtKB=P10163 P10163 PRB4 PTHR23203:SF15 PROLINE-RICH PROTEIN BASIC SALIVARY PROLINE-RICH PROTEIN 4 antimicrobial response protein#PC00051 HUMAN|HGNC=37443|UniProtKB=P0CJ92 P0CJ92 GOLGA8H PTHR10881:SF62 GOLGIN SUBFAMILY A MEMBER-RELATED GOLGIN SUBFAMILY A CONSERVED DOMAIN-CONTAINING PROTEIN-RELATED endomembrane system organization#GO:0010256;cellular component organization or biogenesis#GO:0071840;Golgi organization#GO:0007030;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043 membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;endomembrane system#GO:0012505;Golgi cisterna#GO:0031985;cytoplasm#GO:0005737;Golgi cis cisterna#GO:0000137;Golgi apparatus#GO:0005794;organelle membrane#GO:0031090;cis-Golgi network#GO:0005801;Golgi stack#GO:0005795;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984 membrane traffic protein#PC00150 HUMAN|HGNC=14405|UniProtKB=Q9NQT8 Q9NQT8 KIF13B PTHR24115:SF978 KINESIN-RELATED KINESIN-LIKE PROTEIN KIF13B cytoskeletal motor activity#GO:0003774;hydrolase activity, acting on acid anhydrides#GO:0016817;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;ATP-dependent activity#GO:0140657;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ribonucleoside triphosphate phosphatase activity#GO:0017111;isomerase activity#GO:0016853;macromolecular conformation isomerase activity#GO:0120543;tubulin binding#GO:0015631;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;ATP hydrolysis activity#GO:0016887;microtubule motor activity#GO:0003777;hydrolase activity#GO:0016787;microtubule binding#GO:0008017;polypeptide conformation or assembly isomerase activity#GO:0120544 cellular process#GO:0009987;microtubule-based process#GO:0007017;microtubule-based movement#GO:0007018 cytoskeleton#GO:0005856;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;microtubule associated complex#GO:0005875;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;intracellular organelle#GO:0043229;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;cellular anatomical structure#GO:0110165;organelle#GO:0043226 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=28640|UniProtKB=Q53RE8 Q53RE8 ANKRD39 PTHR24171:SF9 ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HUMAN|HGNC=9630|UniProtKB=P21246 P21246 PTN PTHR13850:SF1 PLEIOTROPHIN FAMILY MEMBER PLEIOTROPHIN molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;growth factor activity#GO:0008083 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207;growth factor#PC00112 HUMAN|HGNC=19256|UniProtKB=Q8TCT0 Q8TCT0 CERK PTHR12358:SF25 SPHINGOSINE KINASE CERAMIDE KINASE lipid kinase activity#GO:0001727;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 ceramide metabolic process#GO:0006672;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;primary metabolic process#GO:0044238;lipid metabolic process#GO:0006629;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transferase#PC00220;kinase#PC00137;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=6377|UniProtKB=O43908 O43908 KLRC4 PTHR22800:SF185 C-TYPE LECTIN PROTEINS NKG2-F TYPE II INTEGRAL MEMBRANE PROTEIN molecular transducer activity#GO:0060089;immune receptor activity#GO:0140375;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 positive regulation of leukocyte mediated immunity#GO:0002705;regulation of response to stress#GO:0080134;positive regulation of immune response#GO:0050778;positive regulation of defense response#GO:0031349;regulation of response to stimulus#GO:0048583;regulation of innate immune response#GO:0045088;innate immune response#GO:0045087;positive regulation of response to biotic stimulus#GO:0002833;response to external stimulus#GO:0009605;defense response#GO:0006952;activation of innate immune response#GO:0002218;positive regulation of natural killer cell mediated cytotoxicity#GO:0045954;positive regulation of cellular process#GO:0048522;immune response#GO:0006955;positive regulation of innate immune response#GO:0045089;positive regulation of response to stimulus#GO:0048584;regulation of natural killer cell mediated cytotoxicity#GO:0042269;immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007;response to other organism#GO:0051707;positive regulation of immune effector process#GO:0002699;regulation of immune response#GO:0050776;regulation of defense response#GO:0031347;positive regulation of lymphocyte mediated immunity#GO:0002708;cell communication#GO:0007154;regulation of immune effector process#GO:0002697;regulation of leukocyte mediated cytotoxicity#GO:0001910;innate immune response-activating signaling pathway#GO:0002758;regulation of leukocyte mediated immunity#GO:0002703;cellular response to stimulus#GO:0051716;regulation of natural killer cell mediated immunity#GO:0002715;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;response to external biotic stimulus#GO:0043207;positive regulation of natural killer cell mediated immunity#GO:0002717;regulation of response to biotic stimulus#GO:0002831;immune response-activating cell surface receptor signaling pathway#GO:0002429;cell surface receptor signaling pathway#GO:0007166;immune effector process#GO:0002252;immune response-activating signaling pathway#GO:0002757;positive regulation of response to external stimulus#GO:0032103;response to biotic stimulus#GO:0009607;positive regulation of immune system process#GO:0002684;response to stress#GO:0006950;defense response to symbiont#GO:0140546;activation of immune response#GO:0002253;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;defense response to other organism#GO:0098542;regulation of response to external stimulus#GO:0032101;immune system process#GO:0002376;regulation of lymphocyte mediated immunity#GO:0002706;regulation of cell killing#GO:0031341;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449;regulation of biological process#GO:0050789;natural killer cell mediated immunity#GO:0002228;immune response-regulating signaling pathway#GO:0002764;response to stimulus#GO:0050896;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;plasma membrane#GO:0005886 defense/immunity protein#PC00090 HUMAN|HGNC=28999|UniProtKB=Q92567 Q92567 FAM168A PTHR31844:SF1 MYELIN-ASSOCIATED NEURITE-OUTGROWTH INHIBITOR-RELATED PROTEIN FAM168A regulation of biological process#GO:0050789;regulation of DNA metabolic process#GO:0051052;positive regulation of DNA metabolic process#GO:0051054;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of cellular response to stress#GO:0080135;positive regulation of metabolic process#GO:0009893;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;positive regulation of DNA repair#GO:0045739;positive regulation of response to stimulus#GO:0048584;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of DNA repair#GO:0006282;regulation of response to stimulus#GO:0048583;regulation of response to stress#GO:0080134 structural protein#PC00211;myelin protein#PC00161 HUMAN|HGNC=2980|UniProtKB=Q9UJW3 Q9UJW3 DNMT3L PTHR23068:SF13 DNA CYTOSINE-5- -METHYLTRANSFERASE 3-RELATED DNA (CYTOSINE-5)-METHYLTRANSFERASE 3-LIKE enzyme activator activity#GO:0008047;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234 regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 DNA methyltransferase#PC00013 HUMAN|HGNC=21202|UniProtKB=Q6ZMV9 Q6ZMV9 KIF6 PTHR24115:SF194 KINESIN-RELATED KINESIN-LIKE PROTEIN KIF6 hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887;microtubule motor activity#GO:0003777;microtubule binding#GO:0008017;polypeptide conformation or assembly isomerase activity#GO:0120544;isomerase activity#GO:0016853;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543;tubulin binding#GO:0015631;protein binding#GO:0005515;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;ATP-dependent activity#GO:0140657;cytoskeletal motor activity#GO:0003774;cytoskeletal protein binding#GO:0008092;hydrolase activity, acting on acid anhydrides#GO:0016817 cellular process#GO:0009987;microtubule-based process#GO:0007017;microtubule-based movement#GO:0007018 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;microtubule#GO:0005874;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoskeleton#GO:0005856;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=28844|UniProtKB=Q6PIJ6 Q6PIJ6 FBXO38 PTHR14753:SF3 F-BOX ONLY PROTEIN 38 F-BOX ONLY PROTEIN 38 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;enzyme-substrate adaptor activity#GO:0140767;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 biological regulation#GO:0065007;post-translational protein modification#GO:0043687;positive regulation of immune effector process#GO:0002699;positive regulation of response to stimulus#GO:0048584;positive regulation of response to biotic stimulus#GO:0002833;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;positive regulation of leukocyte mediated immunity#GO:0002705;protein K48-linked ubiquitination#GO:0070936;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;regulation of response to biotic stimulus#GO:0002831;catabolic process#GO:0009056;regulation of immune system process#GO:0002682;regulation of leukocyte mediated immunity#GO:0002703;modification-dependent protein catabolic process#GO:0019941;protein modification process#GO:0036211;primary metabolic process#GO:0044238;positive regulation of lymphocyte mediated immunity#GO:0002708;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;regulation of immune effector process#GO:0002697;regulation of immune response#GO:0050776;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;protein ubiquitination#GO:0016567;proteasomal protein catabolic process#GO:0010498;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of immune system process#GO:0002684;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;positive regulation of adaptive immune response#GO:0002821;protein polyubiquitination#GO:0000209;regulation of biological process#GO:0050789;protein modification by small protein conjugation#GO:0032446;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein modification by small protein conjugation or removal#GO:0070647;regulation of lymphocyte mediated immunity#GO:0002706 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 HUMAN|HGNC=25265|UniProtKB=Q6NZY4 Q6NZY4 ZCCHC8 PTHR13316:SF0 ZINC FINGER, CCHC DOMAIN CONTAINING 8 ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 8 nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;RNA biosynthetic process#GO:0032774;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;catalytic step 2 spliceosome#GO:0071013;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;spliceosomal complex#GO:0005681;nucleus#GO:0005634;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 RNA metabolism protein#PC00031 HUMAN|HGNC=25556|UniProtKB=Q9NVM6 Q9NVM6 DNAJC17 PTHR44313:SF1 DNAJ HOMOLOG SUBFAMILY C MEMBER 17 DNAJ HOMOLOG SUBFAMILY C MEMBER 17 nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;protein-RNA complex organization#GO:0071826;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-containing complex organization#GO:0043933;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;cellular component disassembly#GO:0022411;RNA metabolic process#GO:0016070;cellular component organization#GO:0016043;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;protein-containing complex disassembly#GO:0032984 ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;spliceosomal complex#GO:0005681;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 chaperone#PC00072 HUMAN|HGNC=30267|UniProtKB=Q86YS3 Q86YS3 RAB11FIP4 PTHR15726:SF5 RAB11-FAMILY INTERACTING PROTEIN RAB11 FAMILY-INTERACTING PROTEIN 4 regulation of cytokinesis#GO:0032465;regulation of cell division#GO:0051302;localization within membrane#GO:0051668;localization#GO:0051179;cellular localization#GO:0051641;regulation of biological process#GO:0050789;endocytic recycling#GO:0032456;regulation of cellular process#GO:0050794;regulation of cell cycle#GO:0051726;intracellular transport#GO:0046907;transport#GO:0006810;establishment of localization#GO:0051234;endosomal transport#GO:0016197;vesicle-mediated transport to the plasma membrane#GO:0098876;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;regulation of cell cycle process#GO:0010564;biological regulation#GO:0065007 membrane#GO:0016020;vesicle membrane#GO:0012506;cell periphery#GO:0071944;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;plasma membrane region#GO:0098590;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cell division site#GO:0032153;recycling endosome#GO:0055037;cleavage furrow#GO:0032154;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;recycling endosome membrane#GO:0055038;midbody#GO:0030496;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;endosome membrane#GO:0010008;endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endocytic vesicle#GO:0030139 HUMAN|HGNC=15754|UniProtKB=P24844 P24844 MYL9 PTHR23049:SF81 MYOSIN REGULATORY LIGHT CHAIN 2 MYOSIN REGULATORY LIGHT POLYPEPTIDE 9 protein binding#GO:0005515;binding#GO:0005488;myosin binding#GO:0017022;cytoskeletal protein binding#GO:0008092 membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;muscle cell development#GO:0055001;muscle cell differentiation#GO:0042692;myofibril assembly#GO:0030239;anatomical structure morphogenesis#GO:0009653;muscle structure development#GO:0061061;actin cytoskeleton organization#GO:0030036;cell differentiation#GO:0030154;cell development#GO:0048468;actomyosin structure organization#GO:0031032;cellular component assembly involved in morphogenesis#GO:0010927;animal gross anatomical part developmental process#GO:0160108;organelle assembly#GO:0070925;actin filament-based process#GO:0030029;anatomical structure development#GO:0048856;striated muscle cell development#GO:0055002;supramolecular fiber organization#GO:0097435;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;cellular anatomical entity morphogenesis#GO:0032989;developmental process#GO:0032502;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;anatomical structure formation involved in morphogenesis#GO:0048646;striated muscle cell differentiation#GO:0051146 contractile muscle fiber#GO:0043292;actomyosin#GO:0042641;myosin complex#GO:0016459;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;stress fiber#GO:0001725;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;actin cytoskeleton#GO:0015629;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;actin filament bundle#GO:0032432;myofibril#GO:0030016 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=24737|UniProtKB=Q5MCW4 Q5MCW4 ZNF569 PTHR24377:SF707 IP01015P-RELATED ZINC FINGER PROTEIN 569 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=18725|UniProtKB=Q68G75 Q68G75 LEMD1 PTHR12019:SF12 LAMINA-ASSOCIATED POLYPEPTIDE THYMOPOIETIN LEM DOMAIN-CONTAINING PROTEIN 1 peptide hormone#PC00179;intercellular signal molecule#PC00207 HUMAN|HGNC=9800|UniProtKB=Q9UNT1 Q9UNT1 RABL2B PTHR24073:SF263 DRAB5-RELATED RAB-LIKE PROTEIN 2A-RELATED hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817 intracellular transport#GO:0046907;transport#GO:0006810;intracellular protein transport#GO:0006886;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;protein transport#GO:0015031;macromolecule localization#GO:0033036;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 G-protein#PC00020;small GTPase#PC00208 HUMAN|HGNC=18391|UniProtKB=Q96PL1 Q96PL1 SCGB3A2 PTHR34829:SF2 SECRETOGLOBIN FAMILY 3A MEMBER 2 SECRETOGLOBIN FAMILY 3A MEMBER 2 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=3719|UniProtKB=Q00688 Q00688 FKBP3 PTHR46493:SF1 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP3 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP3 chaperone#PC00072 HUMAN|HGNC=17687|UniProtKB=Q9Y2P8 Q9Y2P8 RCL1 PTHR11096:SF1 RNA 3' TERMINAL PHOSPHATE CYCLASE RNA 3'-TERMINAL PHOSPHATE CYCLASE-LIKE PROTEIN nuclease activity#GO:0004518;RNA nuclease activity#GO:0004540;endonuclease activity#GO:0004519;RNA endonuclease activity#GO:0004521;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;ligase activity#GO:0016874;cyclase activity#GO:0009975 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;ribonucleoprotein complex biogenesis#GO:0022613;maturation of 5.8S rRNA#GO:0000460;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;maturation of SSU-rRNA#GO:0030490;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000479;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000480;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000447;ribosomal small subunit biogenesis#GO:0042274 intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;small-subunit processome#GO:0032040;organelle lumen#GO:0043233;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;preribosome#GO:0030684;ribonucleoprotein complex#GO:1990904;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013 RNA metabolism protein#PC00031 HUMAN|HGNC=9092|UniProtKB=O15162 O15162 PLSCR1 PTHR23248:SF71 PHOSPHOLIPID SCRAMBLASE-RELATED PHOSPHOLIPID SCRAMBLASE 1 lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104;transporter activity#GO:0005215;phospholipid scramblase activity#GO:0017128;intramembrane lipid carrier activity#GO:0140303 regulation of defense response#GO:0031347;regulation of immune response#GO:0050776;localization#GO:0051179;programmed cell death#GO:0012501;cell death#GO:0008219;regulation of immune system process#GO:0002682;organophosphate ester transport#GO:0015748;regulation of response to biotic stimulus#GO:0002831;lipid translocation#GO:0034204;plasma membrane phospholipid scrambling#GO:0017121;regulation of response to stress#GO:0080134;transport#GO:0006810;regulation of response to stimulus#GO:0048583;positive regulation of defense response#GO:0031349;positive regulation of immune response#GO:0050778;establishment of localization#GO:0051234;regulation of innate immune response#GO:0045088;regulation of membrane lipid distribution#GO:0097035;positive regulation of response to biotic stimulus#GO:0002833;macromolecule localization#GO:0033036;positive regulation of innate immune response#GO:0045089;positive regulation of response to stimulus#GO:0048584;lipid transport#GO:0006869;membrane organization#GO:0061024;phospholipid translocation#GO:0045332;phospholipid transport#GO:0015914;biological regulation#GO:0065007;lipid localization#GO:0010876;plasma membrane organization#GO:0007009;regulation of biological quality#GO:0065008;cellular component organization#GO:0016043;apoptotic process#GO:0006915;execution phase of apoptosis#GO:0097194;regulation of biological process#GO:0050789;positive regulation of response to external stimulus#GO:0032103;cellular component organization or biogenesis#GO:0071840;positive regulation of immune system process#GO:0002684;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;regulation of response to external stimulus#GO:0032101;endomembrane system organization#GO:0010256 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227 HUMAN|HGNC=16098|UniProtKB=Q9BVI0 Q9BVI0 PHF20 PTHR15856:SF27 PHD FINGER PROTEIN 20-RELATED PHD FINGER PROTEIN 20 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 protein acetyltransferase complex#GO:0031248;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;acetyltransferase complex#GO:1902493;NSL complex#GO:0044545;chromosome#GO:0005694;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;methyltransferase complex#GO:0034708;nucleoplasm#GO:0005654;organelle#GO:0043226;histone methyltransferase complex#GO:0035097;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;histone acetyltransferase complex#GO:0000123;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;chromatin#GO:0000785;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;H4 histone acetyltransferase complex#GO:1902562 HUMAN|HGNC=28984|UniProtKB=Q12768 Q12768 WASHC5 PTHR15691:SF6 WASH COMPLEX SUBUNIT 5 WASH COMPLEX SUBUNIT 5 regulation of actin filament-based process#GO:0032970;regulation of actin nucleation#GO:0051125;endosome organization#GO:0007032;vesicle organization#GO:0016050;protein-containing complex organization#GO:0043933;actin filament organization#GO:0007015;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;regulation of actin filament organization#GO:0110053;actin polymerization or depolymerization#GO:0008154;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;regulation of actin cytoskeleton organization#GO:0032956;cytoskeleton organization#GO:0007010;endomembrane system organization#GO:0010256;biological regulation#GO:0065007;cellular component assembly#GO:0022607;actin filament-based process#GO:0030029;supramolecular fiber organization#GO:0097435;organelle fission#GO:0048285;regulation of organelle organization#GO:0033043;protein-containing complex assembly#GO:0065003;protein polymerization#GO:0051258;regulation of biological process#GO:0050789;regulation of supramolecular fiber organization#GO:1902903;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;actin filament polymerization#GO:0030041 intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 membrane traffic protein#PC00150 HUMAN|HGNC=20141|UniProtKB=O95848 O95848 NUDT14 PTHR11839:SF15 UDP/ADP-SUGAR PYROPHOSPHATASE URIDINE DIPHOSPHATE GLUCOSE PYROPHOSPHATASE NUDT14 hydrolase activity#GO:0016787;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817 metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;carbohydrate derivative metabolic process#GO:1901135;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;nucleobase-containing compound metabolic process#GO:0006139 pyrophosphatase#PC00196;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=13032|UniProtKB=P17028 P17028 ZNF24 PTHR23226:SF127 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER PROTEIN 24 transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=30692|UniProtKB=Q6P9F7 Q6P9F7 LRRC8B PTHR45752:SF40 LEUCINE-RICH REPEAT-CONTAINING VOLUME-REGULATED ANION CHANNEL SUBUNIT LRRC8B monoatomic anion channel activity#GO:0005253;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;monoatomic anion transmembrane transporter activity#GO:0008509;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216 transport#GO:0006810;C4-dicarboxylate transport#GO:0015740;establishment of localization#GO:0051234;aspartate transmembrane transport#GO:0015810;nitrogen compound transport#GO:0071705;biological regulation#GO:0065007;dicarboxylic acid transport#GO:0006835;monoatomic ion transmembrane transport#GO:0034220;cell communication#GO:0007154;localization#GO:0051179;amino acid transmembrane transport#GO:0003333;intracellular signal transduction#GO:0035556;monoatomic anion transport#GO:0006820;carbohydrate derivative transport#GO:1901264;cellular response to stimulus#GO:0051716;nucleobase-containing compound transport#GO:0015931;organophosphate ester transport#GO:0015748;regulation of cellular process#GO:0050794;carboxylic acid transmembrane transport#GO:1905039;amino acid transport#GO:0006865;acidic amino acid transport#GO:0015800;carboxylic acid transport#GO:0046942;organic acid transport#GO:0015849;import into cell#GO:0098657;signal transduction#GO:0007165;cellular process#GO:0009987;monoatomic anion transmembrane transport#GO:0098656;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;import across plasma membrane#GO:0098739;signaling#GO:0023052 membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;plasma membrane#GO:0005886;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HUMAN|HGNC=15168|UniProtKB=Q96R67 Q96R67 OR4C12 PTHR48002:SF105 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 4C12 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=12372|UniProtKB=P01222 P01222 TSHB PTHR11515:SF5 GLYCOPROTEIN HORMONE BETA CHAIN THYROTROPIN SUBUNIT BETA signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677;hormone activity#GO:0005179;molecular function regulator activity#GO:0098772 signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 peptide hormone#PC00179 Thyrotropin-releasing hormone receptor signaling pathway#P04394>Thyrotropin#P04588;Thyrotropin-releasing hormone receptor signaling pathway#P04394>ProTRH (Pro Thyrotropin-releasing Hormone)#P04586;Thyrotropin-releasing hormone receptor signaling pathway#P04394>TRH#P04585 HUMAN|HGNC=9605|UniProtKB=P35354 P35354 PTGS2 PTHR11903:SF8 PROSTAGLANDIN G/H SYNTHASE PROSTAGLANDIN G_H SYNTHASE 2 dioxygenase activity#GO:0051213;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen#GO:0016702;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705 monocarboxylic acid biosynthetic process#GO:0072330;unsaturated fatty acid metabolic process#GO:0033559;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;icosanoid biosynthetic process#GO:0046456;biosynthetic process#GO:0009058;fatty acid biosynthetic process#GO:0006633;unsaturated fatty acid biosynthetic process#GO:0006636;lipid biosynthetic process#GO:0008610;icosanoid metabolic process#GO:0006690;cellular process#GO:0009987;long-chain fatty acid metabolic process#GO:0001676;prostaglandin metabolic process#GO:0006693;oxoacid metabolic process#GO:0043436;olefinic compound metabolic process#GO:0120254;small molecule metabolic process#GO:0044281;arachidonate metabolic process#GO:0019369;carboxylic acid biosynthetic process#GO:0046394;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752 neuron projection#GO:0043005;cell projection#GO:0042995;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165 oxygenase#PC00177;oxidoreductase#PC00176 CCKR signaling map#P06959>COX2#G06998;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Cyclooxygenase#P00845;Toll receptor signaling pathway#P00054>Gene trancription#G01550;CCKR signaling map#P06959>COX2#G07292;Endothelin signaling pathway#P00019>COX-2#P00582;CCKR signaling map#P06959>COX2#P07080 HUMAN|HGNC=23292|UniProtKB=P60321 P60321 NANOS2 PTHR12887:SF10 NANOS PROTEIN NANOS HOMOLOG 2 mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 multicellular organismal reproductive process#GO:0048609;anatomical structure development#GO:0048856;sexual reproduction#GO:0019953;negative regulation of protein metabolic process#GO:0051248;reproductive process#GO:0022414;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;germ cell development#GO:0007281;developmental process involved in reproduction#GO:0003006;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;negative regulation of translation#GO:0017148;cellular process involved in reproduction in multicellular organism#GO:0022412;cell development#GO:0048468;negative regulation of metabolic process#GO:0009892;gamete generation#GO:0007276;cell differentiation#GO:0030154;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;oogenesis#GO:0048477;cellular process#GO:0009987;regulation of protein metabolic process#GO:0051246;negative regulation of macromolecule biosynthetic process#GO:0010558 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;perinuclear region of cytoplasm#GO:0048471;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031 HUMAN|HGNC=13104|UniProtKB=Q9Y5A6 Q9Y5A6 ZSCAN21 PTHR23226:SF10 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 21 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=20629|UniProtKB=Q8N972 Q8N972 ZNF709 PTHR24379:SF120 KRAB AND ZINC FINGER DOMAIN-CONTAINING ZINC FINGER PROTEIN 709 double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244;DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=21616|UniProtKB=Q68CZ2 Q68CZ2 TNS3 PTHR45734:SF5 TENSIN TENSIN-3 positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;regulation of small GTPase mediated signal transduction#GO:0051056;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of response to stimulus#GO:0048584;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;positive regulation of signaling#GO:0023056;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794 cell-substrate junction#GO:0030055;focal adhesion#GO:0005925;anchoring junction#GO:0070161;cell junction#GO:0030054;cellular anatomical structure#GO:0110165 non-motor actin binding protein#PC00165;cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=30716|UniProtKB=Q7Z5A4 Q7Z5A4 PRSS42P PTHR24256:SF246 TRYPTASE-RELATED SERINE PROTEASE 42-RELATED serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175 cellular process#GO:0009987;metabolic process#GO:0008152;proteolysis#GO:0006508;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 serine protease#PC00203 HUMAN|HGNC=33525|UniProtKB=P0C7X4 P0C7X4 FTH1P19 PTHR11431:SF97 FERRITIN FERRITIN HEAVY POLYPEPTIDE-LIKE 17-RELATED ferrous iron binding#GO:0008198;iron ion binding#GO:0005506;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;transition metal ion binding#GO:0046914;metal ion binding#GO:0046872;cation binding#GO:0043169 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 storage protein#PC00210 HUMAN|HGNC=3350|UniProtKB=P06733 P06733 ENO1 PTHR11902:SF12 ENOLASE ALPHA-ENOLASE phosphopyruvate hydratase activity#GO:0004634;catalytic activity#GO:0003824;lyase activity#GO:0016829;carbon-oxygen lyase activity#GO:0016835;hydro-lyase activity#GO:0016836 purine ribonucleotide catabolic process#GO:0009154;nucleoside diphosphate catabolic process#GO:0009134;purine nucleoside triphosphate metabolic process#GO:0009144;primary metabolic process#GO:0044238;carbohydrate metabolic process#GO:0005975;nucleoside phosphate metabolic process#GO:0006753;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate derivative catabolic process#GO:1901136;catabolic process#GO:0009056;nucleoside phosphate catabolic process#GO:1901292;pyridine-containing compound metabolic process#GO:0072524;purine nucleotide catabolic process#GO:0006195;nucleoside diphosphate metabolic process#GO:0009132;aerobic respiration#GO:0009060;purine ribonucleoside diphosphate catabolic process#GO:0009181;organophosphate catabolic process#GO:0046434;ribonucleoside diphosphate catabolic process#GO:0009191;cellular respiration#GO:0045333;carbohydrate derivative metabolic process#GO:1901135;ribonucleotide catabolic process#GO:0009261;glycolytic process#GO:0006096;purine ribonucleoside triphosphate metabolic process#GO:0009205;nucleobase-containing compound catabolic process#GO:0034655;organophosphate metabolic process#GO:0019637;nucleobase-containing compound metabolic process#GO:0006139;generation of precursor metabolites and energy#GO:0006091;purine ribonucleoside diphosphate metabolic process#GO:0009179;nucleotide catabolic process#GO:0009166;ADP metabolic process#GO:0046031;energy derivation by oxidation of organic compounds#GO:0015980;purine nucleotide metabolic process#GO:0006163;pyridine-containing compound catabolic process#GO:0072526;ribonucleoside diphosphate metabolic process#GO:0009185;purine-containing compound metabolic process#GO:0072521;monocarboxylic acid metabolic process#GO:0032787;phosphorus metabolic process#GO:0006793;carboxylic acid metabolic process#GO:0019752;pyruvate metabolic process#GO:0006090;pyridine nucleotide catabolic process#GO:0019364;small molecule metabolic process#GO:0044281;oxoacid metabolic process#GO:0043436;ribonucleotide metabolic process#GO:0009259;purine nucleoside diphosphate metabolic process#GO:0009135;carbohydrate catabolic process#GO:0016052;nucleotide metabolic process#GO:0009117;nicotinamide nucleotide metabolic process#GO:0046496;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;ATP metabolic process#GO:0046034;ADP catabolic process#GO:0046032;metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing small molecule metabolic process#GO:0055086;purine nucleoside diphosphate catabolic process#GO:0009137;purine-containing compound catabolic process#GO:0072523 cytosol#GO:0005829;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 metabolite interconversion enzyme#PC00262;lyase#PC00144 Glycolysis#P00024>Enolase#P00678 HUMAN|HGNC=17822|UniProtKB=Q9H7Z7 Q9H7Z7 PTGES2 PTHR12782:SF5 MICROSOMAL PROSTAGLANDIN E SYNTHASE-2 PROSTAGLANDIN E SYNTHASE 2 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739 metabolite interconversion enzyme#PC00262;reductase#PC00198;oxidoreductase#PC00176 HUMAN|HGNC=8506|UniProtKB=P13725 P13725 OSM PTHR14261:SF0 ONCOSTATIN M ONCOSTATIN-M molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;cytokine activity#GO:0005125 regulation of biological process#GO:0050789;positive regulation of biological process#GO:0048518;regulation of response to external stimulus#GO:0032101;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;positive regulation of inflammatory response#GO:0050729;regulation of response to stress#GO:0080134;regulation of response to stimulus#GO:0048583;regulation of defense response#GO:0031347;regulation of inflammatory response#GO:0050727;positive regulation of defense response#GO:0031349;positive regulation of response to external stimulus#GO:0032103 intercellular signal molecule#PC00207;interleukin superfamily#PC00128;cytokine#PC00083 HUMAN|HGNC=26657|UniProtKB=Q8NA75 Q8NA75 DCAF4L2 PTHR44472:SF4 DDB1- AND CUL4-ASSOCIATED FACTOR 4-RELATED DDB1- AND CUL4-ASSOCIATED FACTOR 4-LIKE PROTEIN 2 Cul4-RING E3 ubiquitin ligase complex#GO:0080008;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991 HUMAN|HGNC=31399|UniProtKB=Q9H1V8 Q9H1V8 SLC6A17 PTHR11616:SF102 SODIUM/CHLORIDE DEPENDENT TRANSPORTER SODIUM-DEPENDENT NEUTRAL AMINO ACID TRANSPORTER SLC6A17 sodium ion transport#GO:0006814;metal ion transport#GO:0030001;L-leucine transport#GO:0015820;glycine transport#GO:0015816;localization#GO:0051179;monoatomic cation transport#GO:0006812;neutral amino acid transport#GO:0015804;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;L-amino acid transport#GO:0015807;nitrogen compound transport#GO:0071705;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;alanine transport#GO:0032328;organic acid transport#GO:0015849;carboxylic acid transport#GO:0046942;transport#GO:0006810;amino acid transport#GO:0006865;establishment of localization#GO:0051234;branched-chain amino acid transport#GO:0015803 membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;synaptic vesicle#GO:0008021;intracellular vesicle#GO:0097708;cell junction#GO:0030054;plasma membrane#GO:0005886;cytoplasm#GO:0005737;transport vesicle#GO:0030133;endomembrane system#GO:0012505;presynapse#GO:0098793;cell periphery#GO:0071944;secretory vesicle#GO:0099503;membrane#GO:0016020 primary active transporter#PC00068 Adrenaline and noradrenaline biosynthesis#P00001>amine translocator#P00068 HUMAN|HGNC=34075|UniProtKB=A8MXV6 A8MXV6 CDRT15L2 PTHR16471:SF0 CMT1A DUPLICATED REGION TRANSCRIPT 15 PROTEIN-LIKE PROTEIN CMT1A DUPLICATED REGION TRANSCRIPT 15 PROTEIN-LIKE PROTEIN HUMAN|HGNC=23141|UniProtKB=Q32P41 Q32P41 TRMT5 PTHR23245:SF44 TRNA METHYLTRANSFERASE TRNA (GUANINE(37)-N(1))-METHYLTRANSFERASE transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on RNA#GO:0140098;RNA methyltransferase activity#GO:0008173;tRNA methyltransferase activity#GO:0008175;methyltransferase activity#GO:0008168;catalytic activity, acting on a tRNA#GO:0140101 mitochondrial gene expression#GO:0140053;RNA metabolic process#GO:0016070;RNA methylation#GO:0001510;methylation#GO:0032259;macromolecule modification#GO:0043412;mitochondrial RNA metabolic process#GO:0000959;RNA modification#GO:0009451;macromolecule methylation#GO:0043414;nucleic acid biosynthetic process#GO:0141187;mitochondrial RNA modification#GO:1900864;tRNA modification#GO:0006400;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;mitochondrial RNA processing#GO:0000963;tRNA methylation#GO:0030488;macromolecule biosynthetic process#GO:0009059 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;mitochondrion#GO:0005739 RNA methyltransferase#PC00033 HUMAN|HGNC=4458|UniProtKB=P06744 P06744 GPI PTHR11469:SF1 GLUCOSE-6-PHOSPHATE ISOMERASE GLUCOSE-6-PHOSPHATE ISOMERASE catalytic activity#GO:0003824;intramolecular oxidoreductase activity, interconverting aldoses and ketoses#GO:0016861;intramolecular oxidoreductase activity#GO:0016860;carbohydrate binding#GO:0030246;monosaccharide binding#GO:0048029;isomerase activity#GO:0016853;small molecule binding#GO:0036094;binding#GO:0005488 purine ribonucleoside diphosphate metabolic process#GO:0009179;generation of precursor metabolites and energy#GO:0006091;ADP metabolic process#GO:0046031;glycolytic process#GO:0006096;purine ribonucleoside triphosphate metabolic process#GO:0009205;organophosphate metabolic process#GO:0019637;biosynthetic process#GO:0009058;monosaccharide biosynthetic process#GO:0046364;pyridine-containing compound metabolic process#GO:0072524;nucleoside diphosphate metabolic process#GO:0009132;aerobic respiration#GO:0009060;purine ribonucleoside diphosphate catabolic process#GO:0009181;purine nucleoside triphosphate metabolic process#GO:0009144;primary metabolic process#GO:0044238;hexose metabolic process#GO:0019318;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate derivative catabolic process#GO:1901136;nucleoside phosphate catabolic process#GO:1901292;ADP catabolic process#GO:0046032;purine nucleoside diphosphate catabolic process#GO:0009137;nucleobase-containing small molecule metabolic process#GO:0055086;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;carbohydrate biosynthetic process#GO:0016051;purine nucleoside diphosphate metabolic process#GO:0009135;ribonucleotide metabolic process#GO:0009259;nucleotide metabolic process#GO:0009117;carbohydrate catabolic process#GO:0016052;purine-containing compound metabolic process#GO:0072521;pyridine-containing compound catabolic process#GO:0072526;purine nucleotide metabolic process#GO:0006163;monocarboxylic acid metabolic process#GO:0032787;pyruvate metabolic process#GO:0006090;small molecule biosynthetic process#GO:0044283;nucleotide catabolic process#GO:0009166;energy derivation by oxidation of organic compounds#GO:0015980;carbohydrate derivative metabolic process#GO:1901135;ribonucleotide catabolic process#GO:0009261;nucleobase-containing compound catabolic process#GO:0034655;nucleobase-containing compound metabolic process#GO:0006139;purine nucleotide catabolic process#GO:0006195;cellular respiration#GO:0045333;organophosphate catabolic process#GO:0046434;ribonucleoside diphosphate catabolic process#GO:0009191;nucleoside diphosphate catabolic process#GO:0009134;purine ribonucleotide catabolic process#GO:0009154;hexose biosynthetic process#GO:0019319;nucleoside phosphate metabolic process#GO:0006753;carbohydrate metabolic process#GO:0005975;glucose 6-phosphate metabolic process#GO:0051156;catabolic process#GO:0009056;purine ribonucleotide metabolic process#GO:0009150;monosaccharide metabolic process#GO:0005996;metabolic process#GO:0008152;glucose metabolic process#GO:0006006;purine-containing compound catabolic process#GO:0072523;ATP metabolic process#GO:0046034;nicotinamide nucleotide metabolic process#GO:0046496;gluconeogenesis#GO:0006094;oxoacid metabolic process#GO:0043436;ribonucleoside diphosphate metabolic process#GO:0009185;carboxylic acid metabolic process#GO:0019752;phosphorus metabolic process#GO:0006793;pyridine nucleotide catabolic process#GO:0019364;small molecule metabolic process#GO:0044281 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 isomerase#PC00135;metabolite interconversion enzyme#PC00262 Pentose phosphate pathway#P02762>Glucose-P-Isomerase#P03080;Glycolysis#P00024>Phosphoglucose isomerase#P00674 HUMAN|HGNC=365|UniProtKB=Q9Y6K8 Q9Y6K8 AK5 PTHR23359:SF79 NUCLEOTIDE KINASE ADENYLATE KINASE ISOENZYME 5 transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;nucleobase-containing compound kinase activity#GO:0019205;catalytic activity#GO:0003824;phosphotransferase activity, phosphate group as acceptor#GO:0016776;nucleoside diphosphate kinase activity#GO:0004550 nucleoside diphosphate metabolic process#GO:0009132;ribonucleotide metabolic process#GO:0009259;nucleotide metabolic process#GO:0009117;organophosphate biosynthetic process#GO:0090407;nucleotide biosynthetic process#GO:0009165;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;ribonucleoside diphosphate metabolic process#GO:0009185;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleoside phosphate biosynthetic process#GO:1901293;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;ribose phosphate biosynthetic process#GO:0046390;carbohydrate derivative metabolic process#GO:1901135;pyrimidine-containing compound metabolic process#GO:0072527;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 kinase#PC00137;nucleotide kinase#PC00172 De novo purine biosynthesis#P02738>Adenylate kinase#P02896 HUMAN|HGNC=3703|UniProtKB=Q14192 Q14192 FHL2 PTHR24205:SF3 FOUR AND A HALF LIM DOMAINS PROTEIN FOUR AND A HALF LIM DOMAINS PROTEIN 2 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714 negative regulation of signal transduction#GO:0009968;regulation of calcineurin-NFAT signaling cascade#GO:0070884;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of cell communication#GO:0010648;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of intracellular signal transduction#GO:1902532;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;regulation of signal transduction#GO:0009966;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of response to stimulus#GO:0048585;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;regulation of cell communication#GO:0010646;regulation of calcium-mediated signaling#GO:0050848;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of DNA-templated transcription#GO:0006355 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 transcription cofactor#PC00217 HUMAN|HGNC=10866|UniProtKB=Q11203 Q11203 ST3GAL3 PTHR13713:SF37 SIALYLTRANSFERASE CMP-N-ACETYLNEURAMINATE-BETA-1,4-GALACTOSIDE ALPHA-2,3-SIALYLTRANSFERASE glycosyltransferase activity#GO:0016757;sialyltransferase activity#GO:0008373;transferase activity#GO:0016740;catalytic activity#GO:0003824 biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100 metabolite interconversion enzyme#PC00262;transferase#PC00220 HUMAN|HGNC=6059|UniProtKB=P14902 P14902 IDO1 PTHR28657:SF2 INDOLEAMINE 2,3-DIOXYGENASE INDOLEAMINE 2,3-DIOXYGENASE 1 catalytic activity#GO:0003824;oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen#GO:0016702;dioxygenase activity#GO:0051213;oxidoreductase activity#GO:0016491 metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleobase-containing small molecule metabolic process#GO:0055086;nucleoside phosphate biosynthetic process#GO:1901293;carboxylic acid catabolic process#GO:0046395;nicotinamide nucleotide metabolic process#GO:0046496;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;NAD+ metabolic process#GO:0019674;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;amino acid metabolic process#GO:0006520;proteinogenic amino acid metabolic process#GO:0170039;pyridine-containing compound metabolic process#GO:0072524;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;oxoacid metabolic process#GO:0043436;nucleotide biosynthetic process#GO:0009165;nucleotide metabolic process#GO:0009117;organophosphate biosynthetic process#GO:0090407;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;indole-containing compound metabolic process#GO:0042430;carboxylic acid metabolic process#GO:0019752;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;nucleoside phosphate metabolic process#GO:0006753;small molecule catabolic process#GO:0044282;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 oxygenase#PC00177 HUMAN|HGNC=29537|UniProtKB=Q99687 Q99687 MEIS3 PTHR11850:SF190 HOMEOBOX PROTEIN TRANSCRIPTION FACTORS HOMEOBOX PROTEIN MEIS3 sequence-specific DNA binding#GO:0043565;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;DNA-binding transcription activator activity#GO:0001216;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976 positive regulation of macromolecule metabolic process#GO:0010604;embryo development#GO:0009790;nervous system development#GO:0007399;head development#GO:0060322;sensory system development#GO:0048880;embryonic pattern specification#GO:0009880;positive regulation of biological process#GO:0048518;animal organ development#GO:0048513;multicellular organism development#GO:0007275;positive regulation of transcription by RNA polymerase II#GO:0045944;central nervous system development#GO:0007417;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of cell population proliferation#GO:0008284;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;eye development#GO:0001654;animal gross anatomical part developmental process#GO:0160108;positive regulation of DNA-templated transcription#GO:0045893;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;brain development#GO:0007420;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;sensory organ development#GO:0007423;developmental process#GO:0032502;animal organ morphogenesis#GO:0009887;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;visual system development#GO:0150063;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;positive regulation of biosynthetic process#GO:0009891;regulation of cell population proliferation#GO:0042127;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;pattern specification process#GO:0007389 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 HUMAN|HGNC=12234|UniProtKB=A0A0J9YX75 A0A0J9YX75 TRBV6-9 PTHR23268:SF86 T-CELL RECEPTOR BETA CHAIN T CELL RECEPTOR BETA VARIABLE 6-8-RELATED cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=4034|UniProtKB=P58549 P58549 FXYD7 PTHR14132:SF1 SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT GAMMA FXYD DOMAIN-CONTAINING ION TRANSPORT REGULATOR 7 transporter regulator activity#GO:0141108;ion channel regulator activity#GO:0099106;molecular function regulator activity#GO:0098772;channel regulator activity#GO:0016247 regulation of monoatomic cation transmembrane transport#GO:1904062;regulation of localization#GO:0032879;regulation of transport#GO:0051049;regulation of transmembrane transport#GO:0034762;regulation of monoatomic ion transmembrane transport#GO:0034765;positive regulation of transport#GO:0051050;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of monoatomic ion transport#GO:0043269;regulation of metal ion transport#GO:0010959;biological regulation#GO:0065007 primary active transporter#PC00068;transporter#PC00227 HUMAN|HGNC=26054|UniProtKB=Q96DW6 Q96DW6 SLC25A38 PTHR46181:SF3 MITOCHONDRIAL GLYCINE TRANSPORTER MITOCHONDRIAL GLYCINE TRANSPORTER transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;neutral L-amino acid transmembrane transporter activity#GO:0015175;amino acid transmembrane transporter activity#GO:0015171;glycine transmembrane transporter activity#GO:0015187 establishment of localization#GO:0051234;intracellular transport#GO:0046907;amino acid transport#GO:0006865;organic acid transport#GO:0015849;transport#GO:0006810;carboxylic acid transport#GO:0046942;nitrogen compound transport#GO:0071705;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;neutral amino acid transport#GO:0015804;cellular localization#GO:0051641;transmembrane transport#GO:0055085;amino acid transmembrane transport#GO:0003333;localization#GO:0051179;mitochondrial transmembrane transport#GO:1990542;glycine transport#GO:0015816;mitochondrial transport#GO:0006839;carboxylic acid transmembrane transport#GO:1905039 mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 transporter#PC00227 HUMAN|HGNC=18857|UniProtKB=Q9HCS2 Q9HCS2 CYP4F12 PTHR24291:SF27 CYTOCHROME P450 FAMILY 4 CYTOCHROME P450 4F12 icosanoid metabolic process#GO:0006690;cellular process#GO:0009987;long-chain fatty acid metabolic process#GO:0001676;unsaturated fatty acid metabolic process#GO:0033559;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;small molecule catabolic process#GO:0044282;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;arachidonate metabolic process#GO:0019369;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;vitamin K metabolic process#GO:0042373;carboxylic acid metabolic process#GO:0019752;ketone metabolic process#GO:0042180;oxoacid metabolic process#GO:0043436;olefinic compound metabolic process#GO:0120254 oxygenase#PC00177;metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HUMAN|HGNC=23616|UniProtKB=Q8IY50 Q8IY50 SLC35F3 PTHR19346:SF3 SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN SOLUTE CARRIER FAMILY 35 MEMBER F3 localization#GO:0051179;vitamin transport#GO:0051180;establishment of localization#GO:0051234;nitrogen compound transport#GO:0071705;transport#GO:0006810 HUMAN|HGNC=6833|UniProtKB=P21397 P21397 MAOA PTHR43563:SF11 AMINE OXIDASE AMINE OXIDASE [FLAVIN-CONTAINING] A oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 catabolic process#GO:0009056;biogenic amine metabolic process#GO:0006576;amine metabolic process#GO:0009308;indole-containing compound metabolic process#GO:0042430;cellular process#GO:0009987;phenol-containing compound metabolic process#GO:0018958;serotonin metabolic process#GO:0042428;metabolic process#GO:0008152;amine catabolic process#GO:0009310 mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 oxidase#PC00175;oxidoreductase#PC00176 5-Hydroxytryptamine degredation#P04372>Monoamine Oxidase#P04401;Dopamine receptor mediated signaling pathway#P05912>MAO#P05963;Adrenaline and noradrenaline biosynthesis#P00001>MAO#P00067 HUMAN|HGNC=31838|UniProtKB=Q9H321 Q9H321 VCX3B PTHR15251:SF3 TESTIS-SPECIFIC BASIC PROTEIN Y 1-RELATED TESTIS-SPECIFIC BASIC PROTEIN Y 1-RELATED brain development#GO:0007420;central nervous system development#GO:0007417;multicellular organismal process#GO:0032501;head development#GO:0060322;nervous system development#GO:0007399;animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502;multicellular organism development#GO:0007275;anatomical structure development#GO:0048856;animal organ development#GO:0048513;system development#GO:0048731 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=16086|UniProtKB=Q96NB2 Q96NB2 SFXN2 PTHR11153:SF14 SIDEROFLEXIN SIDEROFLEXIN-2 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 cellular process#GO:0009987;establishment of localization in cell#GO:0051649;nitrogen compound transport#GO:0071705;establishment of localization#GO:0051234;amino acid transport#GO:0006865;transport#GO:0006810;organic acid transport#GO:0015849;carboxylic acid transport#GO:0046942;intracellular transport#GO:0046907;carboxylic acid transmembrane transport#GO:1905039;mitochondrial transport#GO:0006839;amino acid transmembrane transport#GO:0003333;cellular localization#GO:0051641;transmembrane transport#GO:0055085;neutral amino acid transport#GO:0015804;localization#GO:0051179;mitochondrial transmembrane transport#GO:1990542 organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090 primary active transporter#PC00068 HUMAN|HGNC=4411|UniProtKB=P63211 P63211 GNGT1 PTHR13809:SF26 GUANINE NUCLEOTIDE-BINDING PROTEIN GAMMA SUBUNIT GUANINE NUCLEOTIDE-BINDING PROTEIN G(T) SUBUNIT GAMMA-T1 molecular function regulator activity#GO:0098772;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 membrane#GO:0016020;cytoplasmic side of plasma membrane#GO:0009898;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cytoplasmic side of membrane#GO:0098562;extrinsic component of cytoplasmic side of plasma membrane#GO:0031234;catalytic complex#GO:1902494;extrinsic component of plasma membrane#GO:0019897;side of membrane#GO:0098552;extrinsic component of membrane#GO:0019898 heterotrimeric G-protein#PC00117 PI3 kinase pathway#P00048>Gbetagamma#P01188;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Ggamma#P00721;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Ggamma#P00726;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Ggamma#P00751 HUMAN|HGNC=1403|UniProtKB=P54284 P54284 CACNB3 PTHR11824:SF8 VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-3 voltage-gated ion channel#PC00241 5HT2 type receptor mediated signaling pathway#P04374>Ca2+ channel#P04411;Beta2 adrenergic receptor signaling pathway#P04378>Ca2+ channel#P04445;Beta1 adrenergic receptor signaling pathway#P04377>Ca2+ channel#P04438;Oxytocin receptor mediated signaling pathway#P04391>Ca2+ channel#P04535;Thyrotropin-releasing hormone receptor signaling pathway#P04394>Ca2+ channel#P04587 HUMAN|HGNC=10474|UniProtKB=Q9Y265 Q9Y265 RUVBL1 PTHR11093:SF6 RUVB-RELATED REPTIN AND PONTIN RUVB-LIKE 1 ATP-dependent activity, acting on DNA#GO:0008094;ATP-dependent activity#GO:0140657;DNA helicase activity#GO:0003678;isomerase activity#GO:0016853;catalytic activity, acting on DNA#GO:0140097;helicase activity#GO:0004386;macromolecular conformation isomerase activity#GO:0120543;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;protein-RNA complex assembly#GO:0022618;protein-containing complex assembly#GO:0065003;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;ribonucleoprotein complex biogenesis#GO:0022613;chromatin remodeling#GO:0006338;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of gene expression#GO:0010468;protein-containing complex organization#GO:0043933;regulation of biosynthetic process#GO:0009889;protein-RNA complex organization#GO:0071826;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;cellular component biogenesis#GO:0044085;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;chromatin organization#GO:0006325;cellular component assembly#GO:0022607;regulation of nucleobase-containing compound metabolic process#GO:0019219 protein-containing complex#GO:0032991 HUMAN|HGNC=19700|UniProtKB=Q969H4 Q969H4 CNKSR1 PTHR12844:SF10 CONNECTOR ENCHANCER OF KINASE SUPPRESSOR OF RAS CONNECTOR ENHANCER OF KINASE SUPPRESSOR OF RAS 1 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052 scaffold/adaptor protein#PC00226 CCKR signaling map#P06959>CNKSR1#P07029 HUMAN|HGNC=10241|UniProtKB=Q9H814 Q9H814 PHAX PTHR13135:SF0 CYTOSOLIC RESINIFERATOXIN BINDING PROTEIN RBP-26 PHOSPHORYLATED ADAPTER RNA EXPORT PROTEIN protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 nucleocytoplasmic transport#GO:0006913;nuclear transport#GO:0051169;nuclear export#GO:0051168;localization#GO:0051179;nucleic acid transport#GO:0050657;cellular localization#GO:0051641;establishment of RNA localization#GO:0051236;nucleobase-containing compound transport#GO:0015931;RNA transport#GO:0050658;RNA localization#GO:0006403;transport#GO:0006810;RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907;establishment of localization#GO:0051234;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule localization#GO:0033036;nitrogen compound transport#GO:0071705 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 RNA metabolism protein#PC00031 HUMAN|HGNC=15674|UniProtKB=Q9BWW4 Q9BWW4 SSBP3 PTHR12610:SF22 SINGLE STRANDED DNA BINDING PROTEIN SINGLE-STRANDED DNA-BINDING PROTEIN 3 transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 DNA metabolism protein#PC00009 HUMAN|HGNC=28355|UniProtKB=Q86X40 Q86X40 LRRC28 PTHR45752:SF5 LEUCINE-RICH REPEAT-CONTAINING LEUCINE-RICH REPEAT-CONTAINING PROTEIN 28 scaffold/adaptor protein#PC00226 HUMAN|HGNC=30132|UniProtKB=Q6TCH4 Q6TCH4 PAQR6 PTHR20855:SF39 ADIPOR/PROGESTIN RECEPTOR-RELATED MEMBRANE PROGESTIN RECEPTOR DELTA molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=37708|UniProtKB=A8MT19 A8MT19 RHPN2P1 PTHR23031:SF5 RHOPHILIN RHOPHILIN-2-RELATED negative regulation of cellular process#GO:0048523;regulation of actin filament-based process#GO:0032970;regulation of actin filament organization#GO:0110053;biological regulation#GO:0065007;regulation of actin cytoskeleton organization#GO:0032956;negative regulation of cytoskeleton organization#GO:0051494;negative regulation of biological process#GO:0048519;regulation of actin filament bundle assembly#GO:0032231;negative regulation of organelle organization#GO:0010639;negative regulation of cellular component organization#GO:0051129;regulation of biological process#GO:0050789;regulation of supramolecular fiber organization#GO:1902903;regulation of organelle organization#GO:0033043;regulation of cellular component organization#GO:0051128;negative regulation of supramolecular fiber organization#GO:1902904;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794;regulation of stress fiber assembly#GO:0051492;regulation of cellular component biogenesis#GO:0044087 scaffold/adaptor protein#PC00226 HUMAN|HGNC=11195|UniProtKB=P48431 P48431 SOX2 PTHR10270:SF231 SOX TRANSCRIPTION FACTOR TRANSCRIPTION FACTOR SOX-2 binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription activator activity#GO:0001216;transcription regulator activity#GO:0140110;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837 positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of transcription by RNA polymerase II#GO:0000122;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;inner ear development#GO:0048839;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nucleobase-containing compound metabolic process#GO:0019219;brain development#GO:0007420;positive regulation of DNA-templated transcription#GO:0045893;multicellular organismal process#GO:0032501;developmental process#GO:0032502;sensory organ development#GO:0007423;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;central nervous system development#GO:0007417;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;forebrain development#GO:0030900;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;ear development#GO:0043583;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;negative regulation of DNA-templated transcription#GO:0045892;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;head development#GO:0060322;nervous system development#GO:0007399;positive regulation of macromolecule metabolic process#GO:0010604;neuron differentiation#GO:0030182;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;positive regulation of transcription by RNA polymerase II#GO:0045944;multicellular organism development#GO:0007275;animal organ development#GO:0048513 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA-binding transcription factor#PC00218;HMG box transcription factor#PC00024;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=30712|UniProtKB=Q6UWH6 Q6UWH6 TEX261 PTHR13144:SF0 TEX261 PROTEIN PROTEIN TEX261 cargo receptor activity#GO:0038024 endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;transport#GO:0006810;Golgi vesicle transport#GO:0048193;intracellular transport#GO:0046907;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;cellular process#GO:0009987 organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;endoplasmic reticulum#GO:0005783;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;endoplasmic reticulum membrane#GO:0005789;cytoplasm#GO:0005737;endomembrane system#GO:0012505;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;coated vesicle#GO:0030135;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;COPII-coated ER to Golgi transport vesicle#GO:0030134;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708 HUMAN|HGNC=28275|UniProtKB=Q96AQ2 Q96AQ2 TMEM125 PTHR31416:SF1 TRANSMEMBRANE PROTEIN 125 TRANSMEMBRANE PROTEIN 125 HUMAN|HGNC=7408|UniProtKB=P25713 P25713 MT3 PTHR23299:SF18 METALLOTHIONEIN METALLOTHIONEIN-3 binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;cation binding#GO:0043169;metal ion binding#GO:0046872 intracellular monoatomic ion homeostasis#GO:0006873;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of intracellular signal transduction#GO:1902531;cellular response to chemical stimulus#GO:0070887;regulation of signaling#GO:0023051;inorganic ion homeostasis#GO:0098771;positive regulation of signaling#GO:0023056;response to stress#GO:0006950;detoxification of inorganic compound#GO:0061687;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;regulation of ERK1 and ERK2 cascade#GO:0070372;response to chemical#GO:0042221;detoxification#GO:0098754;chemical homeostasis#GO:0048878;regulation of MAPK cascade#GO:0043408;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;positive regulation of cell communication#GO:0010647;response to toxic substance#GO:0009636;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;positive regulation of ERK1 and ERK2 cascade#GO:0070374;homeostatic process#GO:0042592;positive regulation of cellular process#GO:0048522;positive regulation of response to stimulus#GO:0048584;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;response to cadmium ion#GO:0046686;regulation of response to stimulus#GO:0048583;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;positive regulation of intracellular signal transduction#GO:1902533;response to metal ion#GO:0010038;positive regulation of MAPK cascade#GO:0043410;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 defense/immunity protein#PC00090 HUMAN|HGNC=26795|UniProtKB=Q8N8V4 Q8N8V4 ANKS4B PTHR24161:SF20 ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED ANKYRIN REPEAT AND SAM DOMAIN-CONTAINING PROTEIN 4B protein localization to cytoskeleton#GO:0044380;cellular component organization#GO:0016043;macromolecule localization#GO:0033036;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;protein localization to organelle#GO:0033365;cellular component assembly#GO:0022607;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;intracellular protein localization#GO:0008104 plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;organelle#GO:0043226;actin-based cell projection#GO:0098858;microvillus#GO:0005902;cell periphery#GO:0071944;membrane#GO:0016020;actin cytoskeleton#GO:0015629;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 protein modifying enzyme#PC00260 HUMAN|HGNC=20203|UniProtKB=Q8IVI9 Q8IVI9 NOSTRIN PTHR14167:SF31 SH3 DOMAIN-CONTAINING NOSTRIN protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 scaffold/adaptor protein#PC00226 HUMAN|HGNC=19426|UniProtKB=Q8TEX9 Q8TEX9 IPO4 PTHR10527:SF6 IMPORTIN BETA IMPORTIN-4 molecular carrier activity#GO:0140104;nucleocytoplasmic carrier activity#GO:0140142 protein localization to organelle#GO:0033365;nuclear transport#GO:0051169;protein transport#GO:0015031;protein import into nucleus#GO:0006606;localization#GO:0051179;cellular localization#GO:0051641;nucleocytoplasmic transport#GO:0006913;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule localization#GO:0033036;import into nucleus#GO:0051170;protein localization to nucleus#GO:0034504;intracellular protein localization#GO:0008104;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 transporter#PC00227 HUMAN|HGNC=6734|UniProtKB=P12980 P12980 LYL1 PTHR13864:SF6 T-CELL ACUTE LYMPHOCYTIC LEUKEMIA/STEM CELL LEUKEMIA-RELATED PROTEIN LYL-1 transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=28596|UniProtKB=Q8NCR0 Q8NCR0 B3GALNT2 PTHR11214:SF219 BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE UDP-GALNAC:BETA-1,3-N-ACETYLGALACTOSAMINYLTRANSFERASE 2 catalytic activity#GO:0003824;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194 glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;protein O-linked glycosylation#GO:0006493;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;biosynthetic process#GO:0009058 membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;membrane#GO:0016020 transferase#PC00220;glycosyltransferase#PC00111 HUMAN|HGNC=5815|UniProtKB=P04433 P04433 IGKV3-11 PTHR23267:SF328 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN KAPPA VARIABLE 3-11-RELATED response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=16009|UniProtKB=Q9Y574 Q9Y574 ASB4 PTHR24123:SF135 ANKYRIN REPEAT-CONTAINING ANKYRIN REPEAT AND SOCS BOX PROTEIN 4 molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;phosphatase regulator activity#GO:0019208 positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;positive regulation of biological process#GO:0048518;regulation of cellular process#GO:0050794;regulation of developmental process#GO:0050793;biological regulation#GO:0065007;positive regulation of developmental process#GO:0051094;regulation of cell differentiation#GO:0045595;positive regulation of cell differentiation#GO:0045597 ubiquitin ligase complex#GO:0000151;Cul5-RING ubiquitin ligase complex#GO:0031466;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;protein serine/threonine phosphatase complex#GO:0008287;catalytic complex#GO:1902494;transferase complex#GO:1990234;Cul2-RING ubiquitin ligase complex#GO:0031462;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cullin-RING ubiquitin ligase complex#GO:0031461;cytoplasm#GO:0005737;cytosol#GO:0005829 scaffold/adaptor protein#PC00226 HUMAN|HGNC=6285|UniProtKB=Q16558 Q16558 KCNMB1 PTHR10258:SF1 CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA-1 molecular function regulator activity#GO:0098772;channel regulator activity#GO:0016247;ion channel regulator activity#GO:0099106;transporter regulator activity#GO:0141108;potassium channel regulator activity#GO:0015459 nervous system process#GO:0050877;localization#GO:0051179;cell communication#GO:0007154;monoatomic cation transport#GO:0006812;response to calcium ion#GO:0051592;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;action potential#GO:0001508;detection of chemical stimulus#GO:0009593;response to stimulus#GO:0050896;metal ion transport#GO:0030001;response to metal ion#GO:0010038;transport#GO:0006810;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;system process#GO:0003008;transmission of nerve impulse#GO:0019226;detection of stimulus#GO:0051606;cellular process#GO:0009987;potassium ion transport#GO:0006813;response to chemical#GO:0042221;multicellular organismal process#GO:0032501;biological regulation#GO:0065007 protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703 ion channel#PC00133;voltage-gated ion channel#PC00241 HUMAN|HGNC=958|UniProtKB=Q16520 Q16520 BATF PTHR23351:SF14 FOS TRANSCRIPTION FACTOR-RELATED BASIC LEUCINE ZIPPER TRANSCRIPTIONAL FACTOR ATF-LIKE DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 basic leucine zipper transcription factor#PC00056 HUMAN|HGNC=17512|UniProtKB=Q86YM7 Q86YM7 HOMER1 PTHR10918:SF3 HOMER HOMER PROTEIN HOMOLOG 1 G protein-coupled receptor binding#GO:0001664;signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515 signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of metal ion transport#GO:0010959;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;glutamate receptor signaling pathway#GO:0007215;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;biological regulation#GO:0065007;regulation of calcium ion transport#GO:0051924;regulation of monoatomic ion transport#GO:0043269;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of localization#GO:0032879;regulation of transport#GO:0051049;cell surface receptor signaling pathway#GO:0007166 cell junction#GO:0030054;neuron to neuron synapse#GO:0098984;postsynaptic specialization#GO:0099572;cytoplasm#GO:0005737;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005;intracellular anatomical structure#GO:0005622;dendrite#GO:0030425;postsynaptic density#GO:0014069;dendritic tree#GO:0097447;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;asymmetric synapse#GO:0032279;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;postsynapse#GO:0098794 Metabotropic glutamate receptor group I pathway#P00041>Homer#P01058 HUMAN|HGNC=2524|UniProtKB=P40313 P40313 CTRL PTHR24250:SF66 CHYMOTRYPSIN-RELATED CHYMOTRYPSIN-LIKE PROTEASE CTRL-1 serine-type peptidase activity#GO:0008236;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;primary metabolic process#GO:0044238;metabolic process#GO:0008152;proteolysis#GO:0006508 serine protease#PC00203;protein modifying enzyme#PC00260 HUMAN|HGNC=18309|UniProtKB=Q9NWH7 Q9NWH7 SPATA6 PTHR16435:SF3 SPERMATOGENESIS-ASSOCIATED PROTEIN 6 SPATA6 SPERMATOGENESIS-ASSOCIATED PROTEIN 6 protein binding#GO:0005515;myosin binding#GO:0017022;binding#GO:0005488;cytoskeletal protein binding#GO:0008092 spermatogenesis#GO:0007283;developmental process#GO:0032502;plasma membrane bounded cell projection assembly#GO:0120031;cellular component organization or biogenesis#GO:0071840;motile cilium assembly#GO:0044458;cellular process#GO:0009987;cell projection assembly#GO:0030031;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;plasma membrane bounded cell projection organization#GO:0120036;male gamete generation#GO:0048232;cellular component assembly#GO:0022607;sexual reproduction#GO:0019953;organelle assembly#GO:0070925;cilium organization#GO:0044782;multicellular organismal reproductive process#GO:0048609;developmental process involved in reproduction#GO:0003006;cilium assembly#GO:0060271;cellular component organization#GO:0016043;reproductive process#GO:0022414;gamete generation#GO:0007276;cell projection organization#GO:0030030 cellular anatomical structure#GO:0110165 HUMAN|HGNC=15358|UniProtKB=Q8IXE1 Q8IXE1 OR4N5 PTHR48002:SF17 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 4N5 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=10648|UniProtKB=Q12904 Q12904 AIMP1 PTHR11586:SF51 TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN 1 enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;cytokine activity#GO:0005125;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;enzyme activator activity#GO:0008047;signaling receptor regulator activity#GO:0030545 amino acid metabolic process#GO:0006520;cell-cell signaling#GO:0007267;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;biosynthetic process#GO:0009058;gene expression#GO:0010467;cell migration#GO:0016477;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;tRNA aminoacylation for protein translation#GO:0006418;tRNA aminoacylation#GO:0043039;amino acid activation#GO:0043038;macromolecule metabolic process#GO:0043170;tRNA metabolic process#GO:0006399;leukocyte migration#GO:0050900;metabolic process#GO:0008152;signaling#GO:0023052;cell motility#GO:0048870;protein biosynthetic process#GO:0160307;regulation of biological process#GO:0050789;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;protein metabolic process#GO:0019538;cell communication#GO:0007154;translation#GO:0006412;immune system process#GO:0002376 extracellular region#GO:0005576;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular protein-containing complex#GO:0140535 translational protein#PC00263 HUMAN|HGNC=5643|UniProtKB=A0A075B7F1 A0A075B7F1 IGHV3OR16-8 PTHR23266:SF302 IMMUNOGLOBULIN HEAVY CHAIN IG-LIKE DOMAIN-CONTAINING PROTEIN antigen binding#GO:0003823;binding#GO:0005488 immune response#GO:0006955;adaptive immune response#GO:0002250;response to stimulus#GO:0050896;immune effector process#GO:0002252;immune system process#GO:0002376;immunoglobulin mediated immune response#GO:0016064;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=23847|UniProtKB=Q9P1Z0 Q9P1Z0 ZBTB4 PTHR24388:SF58 ZINC FINGER PROTEIN ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 4 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=2680|UniProtKB=Q9BTC0 Q9BTC0 DIDO1 PTHR11477:SF13 TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN DEATH-INDUCER OBLITERATOR 1 RNA metabolism protein#PC00031;general transcription factor#PC00259 HUMAN|HGNC=10853|UniProtKB=O15266 O15266 SHOX PTHR46255:SF2 SHORT STATURE HOMEOBOX SHORT STATURE HOMEOBOX PROTEIN sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulator activity#GO:0140110;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 homeodomain transcription factor#PC00119 HUMAN|HGNC=25461|UniProtKB=Q9BZE2 Q9BZE2 PUS3 PTHR11142:SF5 PSEUDOURIDYLATE SYNTHASE TRNA PSEUDOURIDINE(38_39) SYNTHASE catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098;isomerase activity#GO:0016853;intramolecular transferase activity#GO:0016866;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;tRNA modification#GO:0006400;pseudouridine synthesis#GO:0001522;mRNA modification#GO:0016556;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 lyase#PC00144 HUMAN|HGNC=4162|UniProtKB=P41250 P41250 GARS1 PTHR10745:SF0 GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2 GLYCINE--TRNA LIGASE catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a tRNA#GO:0140101;ligase activity#GO:0016874;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;macromolecule metabolic process#GO:0043170;amino acid activation#GO:0043038;tRNA aminoacylation#GO:0043039;tRNA aminoacylation for protein translation#GO:0006418;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;translation#GO:0006412;mitochondrial RNA metabolic process#GO:0000959;RNA metabolic process#GO:0016070;protein metabolic process#GO:0019538;mitochondrial gene expression#GO:0140053;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mitochondrial translation#GO:0032543;protein biosynthetic process#GO:0160307 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 HUMAN|HGNC=30231|UniProtKB=O75663 O75663 TIPRL PTHR21021:SF16 GAF/PUTATIVE CYTOSKELETAL PROTEIN TIP41-LIKE PROTEIN oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;protein phosphatase regulator activity#GO:0019888;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;catalytic activity#GO:0003824;enzyme activator activity#GO:0008047;phosphatase activator activity#GO:0019211;molecular function regulator activity#GO:0098772;phosphatase regulator activity#GO:0019208;oxidoreductase activity#GO:0016491 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;TOR signaling#GO:0031929;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 HUMAN|HGNC=18018|UniProtKB=Q8IX18 Q8IX18 DHX40 PTHR18934:SF234 ATP-DEPENDENT RNA HELICASE ATP-DEPENDENT RNA HELICASE DHX40-RELATED isomerase activity#GO:0016853;helicase activity#GO:0004386;macromolecular conformation isomerase activity#GO:0120543;catalytic activity#GO:0003824;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;RNA binding#GO:0003723;ATP-dependent activity#GO:0140657;binding#GO:0005488;nucleic acid binding#GO:0003676 RNA helicase#PC00032;RNA metabolism protein#PC00031 HUMAN|HGNC=21148|UniProtKB=Q5XPI4 Q5XPI4 RNF123 PTHR13363:SF5 RING FINGER AND SRY DOMAIN-CONTAINING E3 UBIQUITIN-PROTEIN LIGASE RNF123 ubiquitin-protein transferase activity#GO:0004842;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746 catabolic process#GO:0009056;primary metabolic process#GO:0044238;cellular process#GO:0009987;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;protein catabolic process#GO:0030163 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=28365|UniProtKB=Q5TC79 Q5TC79 ZBTB37 PTHR24399:SF32 ZINC FINGER AND BTB DOMAIN-CONTAINING ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 37 sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;DNA-binding transcription repressor activity#GO:0001217;transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700 negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of cytokine production#GO:0001817;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of multicellular organismal process#GO:0051239;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=12303|UniProtKB=O75962 O75962 TRIO PTHR22826:SF104 RHO GUANINE EXCHANGE FACTOR-RELATED TRIPLE FUNCTIONAL DOMAIN PROTEIN molecular function regulator activity#GO:0098772;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;guanyl-nucleotide exchange factor activity#GO:0005085 cell development#GO:0048468;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell morphogenesis#GO:0000902;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;system development#GO:0048731;axonogenesis#GO:0007409;neuron development#GO:0048666;anatomical structure development#GO:0048856;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;plasma membrane bounded cell projection organization#GO:0120036;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;cellular process#GO:0009987;neuron projection development#GO:0031175;axon guidance#GO:0007411;axon development#GO:0061564;cell projection morphogenesis#GO:0048858;neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;developmental process#GO:0032502;neuron differentiation#GO:0030182;neuron projection morphogenesis#GO:0048812;plasma membrane bounded cell projection morphogenesis#GO:0120039 cellular anatomical structure#GO:0110165;extrinsic component of membrane#GO:0019898;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;membrane#GO:0016020 protein-binding activity modulator#PC00095;guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=21397|UniProtKB=Q8N228 Q8N228 SCML4 PTHR12247:SF85 POLYCOMB GROUP PROTEIN SEX COMB ON MIDLEG-LIKE PROTEIN 4 binding#GO:0005488;chromatin binding#GO:0003682;histone binding#GO:0042393;protein binding#GO:0005515 negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of metabolic process#GO:0009892 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=11788|UniProtKB=P35443 P35443 THBS4 PTHR10199:SF92 THROMBOSPONDIN THROMBOSPONDIN-4 structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 response to stimulus#GO:0050896;response to stress#GO:0006950;response to endoplasmic reticulum stress#GO:0034976;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cellular response to stress#GO:0033554 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012 cell adhesion molecule#PC00069 HUMAN|HGNC=28448|UniProtKB=Q8N661 Q8N661 TMEM86B PTHR31885:SF7 GH04784P LYSOPLASMALOGENASE TMEM86B hydrolase activity#GO:0016787;ether hydrolase activity#GO:0016803;isomerase activity#GO:0016853;intramolecular transferase activity#GO:0016866;catalytic activity#GO:0003824 membrane#GO:0016020;cellular anatomical structure#GO:0110165 HUMAN|HGNC=3026|UniProtKB=P21918 P21918 DRD5 PTHR24248:SF136 ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR D(1B) DOPAMINE RECEPTOR neurotransmitter receptor activity#GO:0030594;transmembrane signaling receptor activity#GO:0004888;postsynaptic neurotransmitter receptor activity#GO:0098960;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;response to nitrogen compound#GO:1901698;adrenergic receptor signaling pathway#GO:0071875;G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887;response to oxygen-containing compound#GO:1901700;response to chemical#GO:0042221;cellular response to nitrogen compound#GO:1901699;biological regulation#GO:0065007;G protein-coupled dopamine receptor signaling pathway#GO:0007212;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GoPCR#P00725;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;Dopamine receptor mediated signaling pathway#P05912>D1/D5#P05948 HUMAN|HGNC=26484|UniProtKB=Q96MR9 Q96MR9 ZNF560 PTHR24381:SF44 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 560 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=661|UniProtKB=Q9NP61 Q9NP61 ARFGAP3 PTHR45686:SF1 ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 3 enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772 vesicle budding from membrane#GO:0006900;vesicle organization#GO:0016050;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;transport#GO:0006810;Golgi vesicle transport#GO:0048193;membrane organization#GO:0061024;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043 GTPase-activating protein#PC00257;protein-binding activity modulator#PC00095 HUMAN|HGNC=30048|UniProtKB=O00625 O00625 PIR PTHR13903:SF33 PIRIN-RELATED PIRIN catalytic activity#GO:0003824;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;oxidoreductase activity#GO:0016491;dioxygenase activity#GO:0051213;oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen#GO:0016702 developmental process#GO:0032502;cellular developmental process#GO:0048869;anatomical structure development#GO:0048856;leukocyte differentiation#GO:0002521;cellular process#GO:0009987;mononuclear cell differentiation#GO:1903131;myeloid cell differentiation#GO:0030099;cell differentiation#GO:0030154;cell development#GO:0048468;hemopoiesis#GO:0030097 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;cytosol#GO:0005829;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HUMAN|HGNC=14686|UniProtKB=P57087 P57087 JAM2 PTHR44663:SF2 JUNCTIONAL ADHESION MOLECULE B JUNCTIONAL ADHESION MOLECULE B cell adhesion molecule#PC00069 HUMAN|HGNC=24810|UniProtKB=Q9NRQ5 Q9NRQ5 SMCO4 PTHR34644:SF2 SINGLE-PASS MEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 SINGLE-PASS MEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 HUMAN|HGNC=13534|UniProtKB=P98198 P98198 ATP8B2 PTHR24092:SF46 PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE PHOSPHOLIPID-TRANSPORTING ATPASE ID ATP-dependent activity#GO:0140657;transporter activity#GO:0005215;ATPase-coupled intramembrane lipid carrier activity#GO:0140326;molecular carrier activity#GO:0140104;lipid carrier activity#GO:0005319;intramembrane lipid carrier activity#GO:0140303 cellular process#GO:0009987;organelle organization#GO:0006996;macromolecule localization#GO:0033036;membrane organization#GO:0061024;endomembrane system organization#GO:0010256;biological regulation#GO:0065007;phospholipid translocation#GO:0045332;phospholipid transport#GO:0015914;lipid transport#GO:0006869;transport#GO:0006810;regulation of membrane lipid distribution#GO:0097035;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;Golgi organization#GO:0007030;cellular component organization#GO:0016043;lipid translocation#GO:0034204;organophosphate ester transport#GO:0015748;lipid localization#GO:0010876;regulation of biological quality#GO:0065008;localization#GO:0051179 cell periphery#GO:0071944;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;plasma membrane#GO:0005886;trans-Golgi network#GO:0005802;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622 primary active transporter#PC00068;transporter#PC00227 HUMAN|HGNC=21232|UniProtKB=Q96G30 Q96G30 MRAP2 PTHR28675:SF1 MELANOCORTIN-2 RECEPTOR ACCESSORY PROTEIN 2 MELANOCORTIN-2 RECEPTOR ACCESSORY PROTEIN 2 protein binding#GO:0005515;molecular function regulator activity#GO:0098772;signaling receptor binding#GO:0005102;binding#GO:0005488;neuropeptide receptor binding#GO:0071855;signaling receptor regulator activity#GO:0030545;G protein-coupled receptor binding#GO:0001664 regulation of signaling#GO:0023051;localization within membrane#GO:0051668;cellular localization#GO:0051641;localization#GO:0051179;protein localization to plasma membrane#GO:0072659;protein localization to membrane#GO:0072657;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;protein localization to cell periphery#GO:1990778;regulation of response to stimulus#GO:0048583;regulation of G protein-coupled receptor signaling pathway#GO:0008277;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;cellular process#GO:0009987;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966 membrane#GO:0016020;cell periphery#GO:0071944;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;plasma membrane#GO:0005886;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=1789|UniProtKB=P42773 P42773 CDKN2C PTHR24201:SF9 ANK_REP_REGION DOMAIN-CONTAINING PROTEIN CYCLIN-DEPENDENT KINASE 4 INHIBITOR C kinase inhibitor activity#GO:0019210;protein kinase regulator activity#GO:0019887;cyclin-dependent protein kinase regulator activity#GO:0019914;cyclin-dependent protein serine/threonine kinase inhibitor activity#GO:0004861;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;protein kinase inhibitor activity#GO:0004860;cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538;enzyme inhibitor activity#GO:0004857;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678 regulation of cell cycle G1/S phase transition#GO:1902806;regulation of cell cycle process#GO:0010564;biological regulation#GO:0065007;regulation of cell cycle#GO:0051726;regulation of cellular process#GO:0050794;regulation of mitotic cell cycle#GO:0007346;regulation of biological process#GO:0050789;negative regulation of cell population proliferation#GO:0008285;negative regulation of biological process#GO:0048519;regulation of cell cycle phase transition#GO:1901987;regulation of mitotic cell cycle phase transition#GO:1901990;regulation of cell population proliferation#GO:0042127;regulation of G1/S transition of mitotic cell cycle#GO:2000045;negative regulation of cellular process#GO:0048523 nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 kinase inhibitor#PC00139;protein-binding activity modulator#PC00095 HUMAN|HGNC=5753|UniProtKB=P01593 P01593 IGKV1D-33 PTHR23267:SF537 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN KAPPA VARIABLE 1-33-RELATED immune system process#GO:0002376;immune response#GO:0006955;response to stimulus#GO:0050896 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=12636|UniProtKB=O95399 O95399 UTS2 PTHR14447:SF0 UROTENSIN 2 UROTENSIN-2 regulation of blood pressure#GO:0008217;circulatory system process#GO:0003013;blood circulation#GO:0008015;multicellular organismal process#GO:0032501;system process#GO:0003008;biological regulation#GO:0065007;regulation of biological quality#GO:0065008 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=4413|UniProtKB=P36915 P36915 GNL1 PTHR45709:SF3 LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 1 hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817 HUMAN|HGNC=49288|UniProtKB=A8MTT3 A8MTT3 CEBPZOS PTHR38001:SF1 PROTEIN CEBPZOS PROTEIN CEBPZOS HUMAN|HGNC=23992|UniProtKB=Q96DX8 Q96DX8 RTP4 PTHR14402:SF23 RECEPTOR TRANSPORTING PROTEIN RECEPTOR-TRANSPORTING PROTEIN 4 protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102;G protein-coupled receptor binding#GO:0001664 sensory perception of bitter taste#GO:0050913;detection of chemical stimulus#GO:0009593;cellular component organization#GO:0016043;protein targeting#GO:0006605;response to stimulus#GO:0050896;detection of chemical stimulus involved in sensory perception of taste#GO:0050912;nervous system process#GO:0050877;localization within membrane#GO:0051668;sensory perception#GO:0007600;detection of chemical stimulus involved in sensory perception#GO:0050907;cellular localization#GO:0051641;localization#GO:0051179;cellular process#GO:0009987;establishment of protein localization#GO:0045184;detection of stimulus involved in sensory perception#GO:0050906;macromolecule localization#GO:0033036;detection of stimulus#GO:0051606;establishment of protein localization to membrane#GO:0090150;membrane organization#GO:0061024;multicellular organismal process#GO:0032501;protein insertion into membrane#GO:0051205;response to chemical#GO:0042221;sensory perception of chemical stimulus#GO:0007606;sensory perception of taste#GO:0050909;protein targeting to membrane#GO:0006612;system process#GO:0003008;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;detection of chemical stimulus involved in sensory perception of bitter taste#GO:0001580;cellular component organization or biogenesis#GO:0071840 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HUMAN|HGNC=9910|UniProtKB=P38159 P38159 RBMX PTHR48034:SF18 TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED RNA-BINDING MOTIF PROTEIN, X CHROMOSOME binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723 RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;spliceosomal complex#GO:0005681;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031 HUMAN|HGNC=30627|UniProtKB=Q8TCT7 Q8TCT7 SPPL2B PTHR12174:SF39 SIGNAL PEPTIDE PEPTIDASE SIGNAL PEPTIDE PEPTIDASE-LIKE 2B catalytic activity#GO:0003824;aspartic-type endopeptidase activity#GO:0004190;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;membrane protein proteolysis#GO:0033619;cellular process#GO:0009987;proteolysis#GO:0006508;metabolic process#GO:0008152;primary metabolic process#GO:0044238 endoplasmic reticulum membrane#GO:0005789;Golgi-associated vesicle#GO:0005798;organelle membrane#GO:0031090;vacuolar membrane#GO:0005774;membrane#GO:0016020;vesicle membrane#GO:0012506;endomembrane system#GO:0012505;endoplasmic reticulum subcompartment#GO:0098827;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;vesicle#GO:0031982;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum#GO:0005783;cytoplasmic side of membrane#GO:0098562;bounding membrane of organelle#GO:0098588;lytic vacuole#GO:0000323;lysosomal membrane#GO:0005765;cytoplasm#GO:0005737;vacuole#GO:0005773;cytoplasmic vesicle membrane#GO:0030659;cytoplasmic side of endoplasmic reticulum membrane#GO:0098554;intracellular organelle#GO:0043229;organelle subcompartment#GO:0031984;side of membrane#GO:0098552;lysosome#GO:0005764;lytic vacuole membrane#GO:0098852;intracellular vesicle#GO:0097708;Golgi-associated vesicle membrane#GO:0030660;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226 protein modifying enzyme#PC00260;aspartic protease#PC00053 HUMAN|HGNC=3188|UniProtKB=O75530 O75530 EED PTHR10253:SF12 POLYCOMB PROTEIN POLYCOMB PROTEIN EED molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234;protein-containing complex binding#GO:0044877;nucleosome binding#GO:0031491;molecular function activator activity#GO:0140677;binding#GO:0005488;chromatin binding#GO:0003682 negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;heterochromatin organization#GO:0070828;cellular component assembly#GO:0022607;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;cellular component organization or biogenesis#GO:0071840;negative regulation of gene expression, epigenetic#GO:0045814;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;heterochromatin formation#GO:0031507;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of cellular process#GO:0048523 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;methyltransferase complex#GO:0034708;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234;histone methyltransferase complex#GO:0035097;protein-containing complex#GO:0032991;PcG protein complex#GO:0031519;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=28155|UniProtKB=Q9H469 Q9H469 FBXL15 PTHR13318:SF179 PARTNER OF PAIRED, ISOFORM B-RELATED F-BOX_LRR-REPEAT PROTEIN 15 ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;metabolic process#GO:0008152;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238 catalytic complex#GO:1902494;transferase complex#GO:1990234;cullin-RING ubiquitin ligase complex#GO:0031461;SCF ubiquitin ligase complex#GO:0019005;intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151 HUMAN|HGNC=202|UniProtKB=O75077 O75077 ADAM23 PTHR11905:SF13 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 23 metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;proteolysis#GO:0006508;metabolic process#GO:0008152;primary metabolic process#GO:0044238;cellular process#GO:0009987 cell junction#GO:0030054;synaptic membrane#GO:0097060;plasma membrane#GO:0005886;presynaptic membrane#GO:0042734;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;synapse#GO:0045202;presynapse#GO:0098793;cell periphery#GO:0071944;membrane#GO:0016020 protease#PC00190;metalloprotease#PC00153 HUMAN|HGNC=37931|UniProtKB=Q96GX2 Q96GX2 ATXN7L3B PTHR47733:SF1 ATAXIN-7 LIKE PROTEIN 3B, ATXN7L3B ATAXIN-7-LIKE PROTEIN 3B regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007 HUMAN|HGNC=24451|UniProtKB=Q8IZD4 Q8IZD4 DCP1B PTHR16290:SF5 TRANSCRIPTION FACTOR SMIF DECAPPING ENZYME DCP1 MRNA-DECAPPING ENZYME 1B mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;negative regulation of biological process#GO:0048519;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;RNA metabolic process#GO:0016070;RNA decapping#GO:0110154;RNA catabolic process#GO:0006401;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;mRNA catabolic process#GO:0006402;nucleobase-containing compound catabolic process#GO:0034655;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;nucleic acid catabolic process#GO:0141188;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of gene expression#GO:0010468;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;negative regulation of cellular process#GO:0048523 P-body#GO:0000932;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737 mRNA capping factor#PC00145;RNA processing factor#PC00147 TGF-beta signaling pathway#P00052>Co-activators corepressors#P01282 HUMAN|HGNC=7975|UniProtKB=P10589 P10589 NR2F1 PTHR24083:SF168 NUCLEAR HORMONE RECEPTOR COUP TRANSCRIPTION FACTOR 1 transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;signaling receptor activity#GO:0038023;sequence-specific DNA binding#GO:0043565;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;nuclear receptor activity#GO:0004879;molecular transducer activity#GO:0060089;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific double-stranded DNA binding#GO:1990837 negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;animal gross anatomical part developmental process#GO:0160108;nervous system development#GO:0007399;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;multicellular organism development#GO:0007275;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;negative regulation of transcription by RNA polymerase II#GO:0000122;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 gene-specific transcriptional regulator#PC00264;C4 zinc finger nuclear receptor#PC00169 HUMAN|HGNC=2746|UniProtKB=P17844 P17844 DDX5 PTHR47958:SF90 ATP-DEPENDENT RNA HELICASE DBP3 ATP-DEPENDENT RNA HELICASE DDX5-RELATED macromolecular conformation isomerase activity#GO:0120543;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;RNA helicase activity#GO:0003724;isomerase activity#GO:0016853;catalytic activity, acting on RNA#GO:0140098;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723 RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;alternative mRNA splicing, via spliceosome#GO:0000380;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;mRNA splicing, via spliceosome#GO:0000398;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774 nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 RNA helicase#PC00032 HUMAN|HGNC=19684|UniProtKB=P0C1S8 P0C1S8 WEE2 PTHR11042:SF75 EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED WEE1-LIKE PROTEIN KINASE 2 phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096 regulation of reproductive process#GO:2000241;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of cell cycle#GO:0051726;regulation of cell cycle process#GO:0010564;regulation of nuclear division#GO:0051783;regulation of biological process#GO:0050789;regulation of meiotic cell cycle#GO:0051445;regulation of organelle organization#GO:0033043 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=26604|UniProtKB=Q8IW93 Q8IW93 ARHGEF19 PTHR12845:SF6 GUANINE NUCLEOTIDE EXCHANGE FACTOR RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 19 molecular function regulator activity#GO:0098772;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;guanyl-nucleotide exchange factor activity#GO:0005085 regulation of actin filament-based process#GO:0032970;wound healing#GO:0042060;response to stress#GO:0006950;response to wounding#GO:0009611;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;regulation of actin cytoskeleton organization#GO:0032956;biological regulation#GO:0065007 protein-binding activity modulator#PC00095;G-protein modulator#PC00022;guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=23089|UniProtKB=Q86YT5 Q86YT5 SLC13A5 PTHR10283:SF109 SOLUTE CARRIER FAMILY 13 MEMBER NA(+)_CITRATE COTRANSPORTER monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;sodium:dicarboxylate symporter activity#GO:0017153;monoatomic cation transmembrane transporter activity#GO:0008324;citrate transmembrane transporter activity#GO:0015137;symporter activity#GO:0015293;dicarboxylic acid transmembrane transporter activity#GO:0005310;solute:monoatomic cation symporter activity#GO:0015294;succinate transmembrane transporter activity#GO:0015141;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;transmembrane transporter activity#GO:0022857;solute:sodium symporter activity#GO:0015370;C4-dicarboxylate transmembrane transporter activity#GO:0015556;carboxylic acid transmembrane transporter activity#GO:0046943 succinate transport#GO:0015744;dicarboxylic acid transport#GO:0006835;cellular process#GO:0009987;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;citrate transport#GO:0015746;tricarboxylic acid transport#GO:0006842;organic acid transport#GO:0015849;transport#GO:0006810;C4-dicarboxylate transport#GO:0015740;carboxylic acid transport#GO:0046942 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 secondary carrier transporter#PC00258;transporter#PC00227 HUMAN|HGNC=17066|UniProtKB=Q9UKV3 Q9UKV3 ACIN1 PTHR46589:SF1 APOPTOTIC CHROMATIN CONDENSATION INDUCER IN THE NUCLEUS APOPTOTIC CHROMATIN CONDENSATION INDUCER IN THE NUCLEUS RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;nucleic acid biosynthetic process#GO:0141187;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA processing#GO:0006396;RNA biosynthetic process#GO:0032774;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;exon-exon junction complex#GO:0035145;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=786|UniProtKB=P18848 P18848 ATF4 PTHR13044:SF2 ACTIVATING TRANSCRIPTION FACTOR ATF 4/5 CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-4 double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;DNA-binding transcription activator activity#GO:0001216;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 Apoptosis signaling pathway#P00006>ATF#P00302 HUMAN|HGNC=14209|UniProtKB=Q86UD4 Q86UD4 ZNF329 PTHR24393:SF141 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 329 nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulator activity#GO:0140110;DNA-binding transcription activator activity#GO:0001216;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;sequence-specific DNA binding#GO:0043565 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=18932|UniProtKB=Q3LI66 Q3LI66 KRTAP6-2 PTHR31678:SF3 KERATIN-ASSOCIATED PROTEIN 6-3 KERATIN-ASSOCIATED PROTEIN 6-2 structural protein#PC00211 HUMAN|HGNC=11161|UniProtKB=P62304 P62304 SNRPE PTHR11193:SF9 SMALL NUCLEAR RIBONUCLEOPROTEIN E SMALL NUCLEAR RIBONUCLEOPROTEIN E cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;cellular component biogenesis#GO:0044085;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;cellular component assembly#GO:0022607;gene expression#GO:0010467;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-RNA complex organization#GO:0071826;mRNA splicing, via spliceosome#GO:0000398;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;ribonucleoprotein complex biogenesis#GO:0022613;spliceosomal snRNP assembly#GO:0000387;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;protein-RNA complex assembly#GO:0022618;RNA metabolic process#GO:0016070 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;spliceosomal snRNP complex#GO:0097525;spliceosomal tri-snRNP complex#GO:0097526;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;precatalytic spliceosome#GO:0071011;intracellular membrane-bounded organelle#GO:0043231;U4 snRNP#GO:0005687;cellular anatomical structure#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681;U5 snRNP#GO:0005682;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513;U2 snRNP#GO:0005686;cytoplasm#GO:0005737;U1 snRNP#GO:0005685;protein-containing complex#GO:0032991;U4/U6 x U5 tri-snRNP complex#GO:0046540;nucleus#GO:0005634;small nuclear ribonucleoprotein complex#GO:0030532 RNA splicing factor#PC00148 HUMAN|HGNC=17715|UniProtKB=Q8N6N7 Q8N6N7 ACBD7 PTHR23310:SF51 ACYL-COA-BINDING PROTEIN, ACBP ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 7 nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167;binding#GO:0005488;anion binding#GO:0043168;small molecule binding#GO:0036094;lipid binding#GO:0008289;heterocyclic compound binding#GO:1901363 fatty acid metabolic process#GO:0006631;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;small molecule metabolic process#GO:0044281;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;monocarboxylic acid metabolic process#GO:0032787;cellular process#GO:0009987 transfer/carrier protein#PC00219 HUMAN|HGNC=24126|UniProtKB=Q96SQ7 Q96SQ7 ATOH8 PTHR19290:SF102 BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED TRANSCRIPTION FACTOR ATOH8 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;positive regulation of biosynthetic process#GO:0009891;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;developmental process#GO:0032502;sensory organ development#GO:0007423;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;axon development#GO:0061564;regulation of primary metabolic process#GO:0080090;plasma membrane bounded cell projection organization#GO:0120036;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of DNA-templated transcription#GO:0045893;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;neuron development#GO:0048666;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;cell development#GO:0048468;regulation of transcription by RNA polymerase II#GO:0006357;cell projection organization#GO:0030030;cell differentiation#GO:0030154;neuron differentiation#GO:0030182;positive regulation of transcription by RNA polymerase II#GO:0045944;animal organ development#GO:0048513;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;neuron projection development#GO:0031175;nervous system development#GO:0007399;positive regulation of macromolecule metabolic process#GO:0010604 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=4096|UniProtKB=O75293 O75293 GADD45B PTHR10411:SF5 GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 BETA molecular sequestering activity#GO:0140313;protein sequestering activity#GO:0140311 regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;positive regulation of JNK cascade#GO:0046330;positive regulation of signaling#GO:0023056;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;regulation of cell cycle#GO:0051726;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;positive regulation of intracellular signal transduction#GO:1902533;regulation of MAPK cascade#GO:0043408;regulation of response to stimulus#GO:0048583;regulation of JNK cascade#GO:0046328;positive regulation of MAPK cascade#GO:0043410;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 p53 pathway#P00059>GADD45#P04626;p53 pathway#P00059>GADD45#G01575 HUMAN|HGNC=32427|UniProtKB=O60309 O60309 LRRC37A3 PTHR23045:SF9 LEUCINE-RICH REPEAT-CONTAINING PROTEIN 37A LEUCINE-RICH REPEAT-CONTAINING PROTEIN 37A-RELATED transmembrane signal receptor#PC00197 HUMAN|HGNC=21368|UniProtKB=Q6IEG0 Q6IEG0 SNRNP48 PTHR21402:SF15 GAMETOCYTE SPECIFIC FACTOR 1-RELATED U11_U12 SMALL NUCLEAR RIBONUCLEOPROTEIN 48 KDA PROTEIN membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;spliceosomal complex#GO:0005681;organelle lumen#GO:0043233;U12-type spliceosomal complex#GO:0005689;nuclear protein-containing complex#GO:0140513;protein-containing complex#GO:0032991;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 HUMAN|HGNC=26479|UniProtKB=Q96MU6 Q96MU6 ZNF778 PTHR24381:SF153 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 778 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=6143|UniProtKB=Q13683 Q13683 ITGA7 PTHR23220:SF90 INTEGRIN ALPHA INTEGRIN ALPHA-7 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 leukocyte migration#GO:0050900;cell surface receptor signaling pathway#GO:0007166;cell migration#GO:0016477;biological regulation#GO:0065007;cell-cell adhesion#GO:0098609;cellular process#GO:0009987;signal transduction#GO:0007165;cell communication#GO:0007154;cell-substrate adhesion#GO:0031589;immune system process#GO:0002376;cell adhesion#GO:0007155;cell-matrix adhesion#GO:0007160;cell motility#GO:0048870;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;integrin-mediated signaling pathway#GO:0007229;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789 cell periphery#GO:0071944;protein complex involved in cell adhesion#GO:0098636;plasma membrane protein complex#GO:0098797;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cell surface#GO:0009986;signaling receptor complex#GO:0043235;integrin complex#GO:0008305 cell adhesion molecule#PC00069;integrin#PC00126 Integrin signalling pathway#P00034>Integrin alpha#P00941 HUMAN|HGNC=19109|UniProtKB=P59543 P59543 TAS2R20 PTHR11394:SF173 TASTE RECEPTOR TYPE 2 TASTE RECEPTOR TYPE 2 MEMBER 20 transmembrane signaling receptor activity#GO:0004888;taste receptor activity#GO:0008527;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;bitter taste receptor activity#GO:0033038 system process#GO:0003008;detection of chemical stimulus involved in sensory perception of bitter taste#GO:0001580;sensory perception#GO:0007600;nervous system process#GO:0050877;detection of chemical stimulus involved in sensory perception of taste#GO:0050912;sensory perception of taste#GO:0050909;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;response to stimulus#GO:0050896;response to chemical#GO:0042221;multicellular organismal process#GO:0032501;sensory perception of bitter taste#GO:0050913;detection of chemical stimulus#GO:0009593;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906 membrane#GO:0016020;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=13007|UniProtKB=Q9UL58 Q9UL58 ZNF215 PTHR23226:SF65 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER PROTEIN 215 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=6572|UniProtKB=O95970 O95970 LGI1 PTHR24367:SF17 LEUCINE-RICH REPEAT-CONTAINING PROTEIN LEUCINE-RICH GLIOMA-INACTIVATED PROTEIN 1 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=53651|UniProtKB=A0A1B0GUW6 A0A1B0GUW6 SPEM3 PTHR34834:SF3 SPERMATID MATURATION PROTEIN 1 SPEM FAMILY MEMBER 3 developmental process involved in reproduction#GO:0003006;sperm motility#GO:0097722;germ cell development#GO:0007281;anatomical structure morphogenesis#GO:0009653;cell motility#GO:0048870;gamete generation#GO:0007276;microtubule-based movement#GO:0007018;cell differentiation#GO:0030154;cell development#GO:0048468;cellular process involved in reproduction in multicellular organism#GO:0022412;reproductive process#GO:0022414;spermatid differentiation#GO:0048515;spermatid development#GO:0007286;cilium or flagellum-dependent cell motility#GO:0001539;cilium movement#GO:0003341;sexual reproduction#GO:0019953;anatomical structure development#GO:0048856;cilium-dependent cell motility#GO:0060285;multicellular organismal reproductive process#GO:0048609;cilium movement involved in cell motility#GO:0060294;cellular process#GO:0009987;male gamete generation#GO:0048232;multicellular organismal process#GO:0032501;flagellated sperm motility#GO:0030317;developmental process#GO:0032502;spermatogenesis#GO:0007283;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;microtubule-based process#GO:0007017;anatomical structure formation involved in morphogenesis#GO:0048646 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=8522|UniProtKB=P32243 P32243 OTX2 PTHR45793:SF2 HOMEOBOX PROTEIN HOMEOBOX PROTEIN OTX2 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=6159|UniProtKB=P56537 P56537 EIF6 PTHR10784:SF0 TRANSLATION INITIATION FACTOR 6 EUKARYOTIC TRANSLATION INITIATION FACTOR 6 binding#GO:0005488;ribosomal large subunit binding#GO:0043023;ribonucleoprotein complex binding#GO:0043021;ribosome binding#GO:0043022;protein-containing complex binding#GO:0044877 cellular localization#GO:0051641;RNA metabolic process#GO:0016070;ribosome assembly#GO:0042255;ribosomal large subunit biogenesis#GO:0042273;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;establishment of organelle localization#GO:0051656;maturation of 5.8S rRNA#GO:0000460;ribonucleoprotein complex biogenesis#GO:0022613;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;cellular component organization or biogenesis#GO:0071840;protein-RNA complex organization#GO:0071826;protein-containing complex organization#GO:0043933;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;cellular component assembly#GO:0022607;gene expression#GO:0010467;RNA processing#GO:0006396;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;localization#GO:0051179;protein-RNA complex assembly#GO:0022618;nuclear transport#GO:0051169;rRNA processing#GO:0006364;nuclear export#GO:0051168;organelle assembly#GO:0070925;organelle localization#GO:0051640;ribosome localization#GO:0033750;nucleocytoplasmic transport#GO:0006913;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;establishment of localization#GO:0051234;intracellular transport#GO:0046907;ribosomal subunit export from nucleus#GO:0000054;rRNA metabolic process#GO:0016072;transport#GO:0006810;maturation of LSU-rRNA#GO:0000470;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;ribosomal large subunit assembly#GO:0000027;macromolecule biosynthetic process#GO:0009059 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 translation initiation factor#PC00224 HUMAN|HGNC=28070|UniProtKB=Q5TH74 Q5TH74 STPG1 PTHR21580:SF21 SHIPPO-1-RELATED O(6)-METHYLGUANINE-INDUCED APOPTOSIS 2 cellular component organization or biogenesis#GO:0071840;regulation of biological quality#GO:0065008;regulation of membrane permeability#GO:0090559;regulation of mitochondrial membrane permeability#GO:0046902;mitochondrion organization#GO:0007005;biological regulation#GO:0065007;apoptotic mitochondrial changes#GO:0008637;organelle organization#GO:0006996;programmed cell death#GO:0012501;cellular component organization#GO:0016043;cellular process#GO:0009987;apoptotic process#GO:0006915;cell death#GO:0008219 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228;cellular anatomical structure#GO:0110165;organelle#GO:0043226 structural protein#PC00211 HUMAN|HGNC=3238|UniProtKB=P18146 P18146 EGR1 PTHR23235:SF42 KRUEPPEL-LIKE TRANSCRIPTION FACTOR EARLY GROWTH RESPONSE PROTEIN 1 double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;system process#GO:0003008;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;cognition#GO:0050890;nervous system process#GO:0050877;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 C2H2 zinc finger transcription factor#PC00248 Gonadotropin-releasing hormone receptor pathway#P06664>EGR1#G06672;Angiotensin II-stimulated signaling through G proteins and beta-arrestin#P05911>EGR#P05931;Gonadotropin-releasing hormone receptor pathway#P06664>EGR1#G06887;CCKR signaling map#P06959>EGR1#P07192;Gonadotropin-releasing hormone receptor pathway#P06664>EGR1#P06837 HUMAN|HGNC=33844|UniProtKB=Q49A17 Q49A17 GALNTL6 PTHR11675:SF129 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE-LIKE 6 polypeptide N-acetylgalactosaminyltransferase activity#GO:0004653;hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740;UDP-glycosyltransferase activity#GO:0008194;catalytic activity, acting on a protein#GO:0140096;acetylgalactosaminyltransferase activity#GO:0008376;glycosyltransferase activity#GO:0016757 metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;cellular process#GO:0009987;protein O-linked glycosylation#GO:0006493;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;biosynthetic process#GO:0009058 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 glycosyltransferase#PC00111;transferase#PC00220 HUMAN|HGNC=30372|UniProtKB=Q2TBA0 Q2TBA0 KLHL40 PTHR24412:SF22 KELCH PROTEIN KELCH-LIKE PROTEIN 40 ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 cellular process#GO:0009987;regulation of protein metabolic process#GO:0051246;proteasomal protein catabolic process#GO:0010498;negative regulation of protein catabolic process#GO:0042177;regulation of proteasomal protein catabolic process#GO:0061136;striated muscle tissue development#GO:0014706;muscle organ development#GO:0007517;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;negative regulation of ubiquitin-dependent protein catabolic process#GO:2000059;striated muscle cell differentiation#GO:0051146;animal organ development#GO:0048513;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of protein modification by small protein conjugation or removal#GO:1903320;negative regulation of metabolic process#GO:0009892;cell development#GO:0048468;cell differentiation#GO:0030154;negative regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032435;protein catabolic process#GO:0030163;negative regulation of protein ubiquitination#GO:0031397;modification-dependent macromolecule catabolic process#GO:0043632;skeletal muscle organ development#GO:0060538;animal gross anatomical part developmental process#GO:0160108;regulation of post-translational protein modification#GO:1901873;striated muscle cell development#GO:0055002;negative regulation of macromolecule metabolic process#GO:0010605;skeletal muscle tissue development#GO:0007519;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;tissue development#GO:0009888;developmental process#GO:0032502;regulation of protein ubiquitination#GO:0031396;negative regulation of cellular process#GO:0048523;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;regulation of protein modification process#GO:0031399;regulation of catabolic process#GO:0009894;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;cellular developmental process#GO:0048869;modification-dependent protein catabolic process#GO:0019941;muscle cell differentiation#GO:0042692;muscle cell development#GO:0055001;primary metabolic process#GO:0044238;negative regulation of proteasomal protein catabolic process#GO:1901799;negative regulation of protein metabolic process#GO:0051248;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;muscle structure development#GO:0061061;regulation of cellular process#GO:0050794;muscle tissue development#GO:0060537;negative regulation of catabolic process#GO:0009895;regulation of protein catabolic process#GO:0042176;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434;protein metabolic process#GO:0019538;anatomical structure development#GO:0048856 contractile muscle fiber#GO:0043292;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;I band#GO:0031674;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;sarcomere#GO:0030017;Cul3-RING ubiquitin ligase complex#GO:0031463;membraneless organelle#GO:0043228;A band#GO:0031672;cullin-RING ubiquitin ligase complex#GO:0031461;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;myofibril#GO:0030016;ubiquitin ligase complex#GO:0000151 scaffold/adaptor protein#PC00226 HUMAN|HGNC=3356|UniProtKB=P22413 P22413 ENPP1 PTHR10151:SF77 ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE ECTONUCLEOTIDE PYROPHOSPHATASE_PHOSPHODIESTERASE FAMILY MEMBER 1 exonuclease activity#GO:0004527;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;nuclease activity#GO:0004518;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity, acting on ester bonds#GO:0016788;pyrophosphatase activity#GO:0016462;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578 organophosphate metabolic process#GO:0019637;carbohydrate derivative metabolic process#GO:1901135;purine ribonucleoside triphosphate metabolic process#GO:0009205;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;regulation of bone mineralization#GO:0030500;negative regulation of cellular process#GO:0048523;regulation of cell differentiation#GO:0045595;transport#GO:0006810;establishment of localization#GO:0051234;primary metabolic process#GO:0044238;purine nucleoside triphosphate metabolic process#GO:0009144;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;regulation of developmental process#GO:0050793;nucleoside phosphate metabolic process#GO:0006753;nucleoside triphosphate metabolic process#GO:0009141;localization#GO:0051179;ribose phosphate metabolic process#GO:0019693;ATP metabolic process#GO:0046034;cellular process#GO:0009987;regulation of multicellular organismal process#GO:0051239;metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing small molecule metabolic process#GO:0055086;negative regulation of biological process#GO:0048519;phosphorus metabolic process#GO:0006793;purine nucleotide metabolic process#GO:0006163;regulation of biological process#GO:0050789;purine-containing compound metabolic process#GO:0072521;regulation of multicellular organismal development#GO:2000026;small molecule metabolic process#GO:0044281;ribonucleotide metabolic process#GO:0009259;nucleotide metabolic process#GO:0009117;inorganic anion transport#GO:0015698 extracellular region#GO:0005576;basal plasma membrane#GO:0009925;cell periphery#GO:0071944;basal part of cell#GO:0045178;basolateral plasma membrane#GO:0016323;membrane#GO:0016020;plasma membrane#GO:0005886;plasma membrane region#GO:0098590;cell surface#GO:0009986;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HUMAN|HGNC=6678|UniProtKB=P22079 P22079 LPO PTHR11475:SF67 OXIDASE/PEROXIDASE LACTOPEROXIDASE antioxidant activity#GO:0016209;peroxidase activity#GO:0004601;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on peroxide as acceptor#GO:0016684 response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;defense response to bacterium#GO:0042742;response to bacterium#GO:0009617;immune system process#GO:0002376;defense response to symbiont#GO:0140546;immune response#GO:0006955;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;response to other organism#GO:0051707;defense response to other organism#GO:0098542;humoral immune response#GO:0006959;antimicrobial humoral response#GO:0019730;defense response#GO:0006952;response to external stimulus#GO:0009605;antibacterial humoral response#GO:0019731 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 peroxidase#PC00180;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=6338|UniProtKB=P43629 P43629 KIR3DL1 PTHR11738:SF166 MHC CLASS I NK CELL RECEPTOR KILLER CELL IMMUNOGLOBULIN-LIKE RECEPTOR 3DL1-RELATED signaling receptor activity#GO:0038023;immune receptor activity#GO:0140375;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 cell surface receptor signaling pathway#GO:0007166;regulation of response to stimulus#GO:0048583;regulation of immune response#GO:0050776;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;immune response-regulating signaling pathway#GO:0002764;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;signaling#GO:0023052;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=11781|UniProtKB=O43548 O43548 TGM5 PTHR11590:SF38 PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE 5 acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 transferase#PC00220 HUMAN|HGNC=2951|UniProtKB=Q9C0G6 Q9C0G6 DNAH6 PTHR10676:SF339 DYNEIN HEAVY CHAIN FAMILY PROTEIN DYNEIN AXONEMAL HEAVY CHAIN 6 isomerase activity#GO:0016853;cytoskeletal motor activity#GO:0003774;macromolecular conformation isomerase activity#GO:0120543;catalytic activity#GO:0003824;microtubule motor activity#GO:0003777;protein binding#GO:0005515;ATP-dependent activity#GO:0140657;binding#GO:0005488;polypeptide conformation or assembly isomerase activity#GO:0120544 cellular process#GO:0009987;cilium movement involved in cell motility#GO:0060294;cell motility#GO:0048870;microtubule-based movement#GO:0007018;cilium or flagellum-dependent cell motility#GO:0001539;cilium movement#GO:0003341;microtubule-based process#GO:0007017;cilium-dependent cell motility#GO:0060285 cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;cilium#GO:0005929;9+2 motile cilium#GO:0097729;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;dynein complex#GO:0030286;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;motile cilium#GO:0031514 microtubule or microtubule-binding cytoskeletal protein#PC00157;microtubule binding motor protein#PC00156 Huntington disease#P00029>Dynein complex#P00774 HUMAN|HGNC=10921|UniProtKB=Q16348 Q16348 SLC15A2 PTHR11654:SF603 OLIGOPEPTIDE TRANSPORTER-RELATED SOLUTE CARRIER FAMILY 15 MEMBER 2 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;dipeptide transmembrane transporter activity#GO:0071916;oligopeptide transmembrane transporter activity#GO:0035673 import across plasma membrane#GO:0098739;peptide transport#GO:0015833;nitrogen compound transport#GO:0071705;oligopeptide transmembrane transport#GO:0035672;cellular process#GO:0009987;localization#GO:0051179;establishment of localization#GO:0051234;import into cell#GO:0098657;transmembrane transport#GO:0055085;dipeptide transport#GO:0042938;oligopeptide transport#GO:0006857;transport#GO:0006810 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;cell periphery#GO:0071944;apical part of cell#GO:0045177;membrane#GO:0016020;apical plasma membrane#GO:0016324 transporter#PC00227 HUMAN|HGNC=20359|UniProtKB=Q6ZU80 Q6ZU80 CEP128 PTHR46657:SF1 CENTROSOMAL PROTEIN OF 128 KDA CENTROSOMAL PROTEIN 128 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;centriole#GO:0005814;microtubule cytoskeleton#GO:0015630;spindle pole#GO:0000922;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;spindle#GO:0005819;microtubule organizing center#GO:0005815;intracellular organelle#GO:0043229 HUMAN|HGNC=17550|UniProtKB=Q96MU8 Q96MU8 KREMEN1 PTHR24269:SF13 KREMEN PROTEIN KREMEN PROTEIN 1 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 Wnt signaling pathway#P00057>Kremen#P01463 HUMAN|HGNC=38652|UniProtKB=D6RF30 D6RF30 GOLGA8K PTHR10881:SF62 GOLGIN SUBFAMILY A MEMBER-RELATED GOLGIN SUBFAMILY A CONSERVED DOMAIN-CONTAINING PROTEIN-RELATED cellular process#GO:0009987;Golgi organization#GO:0007030;cellular component organization#GO:0016043;organelle organization#GO:0006996;endomembrane system organization#GO:0010256;cellular component organization or biogenesis#GO:0071840 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;Golgi stack#GO:0005795;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;Golgi apparatus#GO:0005794;organelle membrane#GO:0031090;cis-Golgi network#GO:0005801;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;cytoplasm#GO:0005737;Golgi cis cisterna#GO:0000137;endomembrane system#GO:0012505;Golgi cisterna#GO:0031985 membrane traffic protein#PC00150 HUMAN|HGNC=26367|UniProtKB=Q8N7G0 Q8N7G0 POU5F2 PTHR11636:SF14 POU DOMAIN POU DOMAIN, CLASS 5, TRANSCRIPTION FACTOR 2 cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=6589|UniProtKB=Q86UP9 Q86UP9 LHFPL3 PTHR12489:SF13 LIPOMA HMGIC FUSION PARTNER-LIKE PROTEIN LHFPL TETRASPAN SUBFAMILY MEMBER 3 PROTEIN multicellular organismal process#GO:0032501;sensory perception of sound#GO:0007605;system process#GO:0003008;nervous system process#GO:0050877;sensory perception of mechanical stimulus#GO:0050954;sensory perception#GO:0007600 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HUMAN|HGNC=26142|UniProtKB=Q9H6X4 Q9H6X4 TMEM134 PTHR13558:SF1 TRANSMEMBRANE PROTEIN 134 TRANSMEMBRANE PROTEIN 134 HUMAN|HGNC=7045|UniProtKB=Q10469 Q10469 MGAT2 PTHR12871:SF0 BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE II ALPHA-1,6-MANNOSYL-GLYCOPROTEIN 2-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194;catalytic activity, acting on a protein#GO:0140096;acetylglucosaminyltransferase activity#GO:0008375;transferase activity#GO:0016740;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487;glycoprotein biosynthetic process#GO:0009101;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;biosynthetic process#GO:0009058;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 glycosyltransferase#PC00111 HUMAN|HGNC=26166|UniProtKB=Q6ZN55 Q6ZN55 ZNF574 PTHR24376:SF69 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 574 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=25895|UniProtKB=Q53GL7 Q53GL7 PARP10 PTHR14453:SF94 PARP/ZINC FINGER CCCH TYPE DOMAIN CONTAINING PROTEIN PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP10 transcription regulator activity#GO:0140110;pentosyltransferase activity#GO:0016763;NAD+ poly-ADP-ribosyltransferase activity#GO:0003950;glycosyltransferase activity#GO:0016757;transferase activity#GO:0016740;transcription corepressor activity#GO:0003714;catalytic activity#GO:0003824;transcription coregulator activity#GO:0003712 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of gene expression#GO:0010629;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of macromolecule metabolic process#GO:0010605;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of metabolic process#GO:0009892;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=26257|UniProtKB=Q9H5P4 Q9H5P4 PDZD7 PTHR23116:SF29 PDZ DOMAIN CONTAINING WHIRLIN AND HARMONIN-RELATED PDZ DOMAIN-CONTAINING PROTEIN 7 plasma membrane bounded cell projection organization#GO:0120036;epithelium development#GO:0060429;tissue development#GO:0009888;epithelial cell differentiation#GO:0030855;epidermal cell differentiation#GO:0009913;multicellular organismal process#GO:0032501;inner ear development#GO:0048839;system process#GO:0003008;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;developmental process#GO:0032502;sensory organ development#GO:0007423;epidermis development#GO:0008544;animal organ morphogenesis#GO:0009887;system development#GO:0048731;anatomical structure development#GO:0048856;sensory perception of mechanical stimulus#GO:0050954;sensory perception#GO:0007600;embryonic organ development#GO:0048568;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;embryo development#GO:0009790;cellular process#GO:0009987;inner ear morphogenesis#GO:0042472;neuron projection development#GO:0031175;hair cell differentiation#GO:0035315;multicellular organism development#GO:0007275;embryonic morphogenesis#GO:0048598;cellular component organization or biogenesis#GO:0071840;animal organ development#GO:0048513;neuron differentiation#GO:0030182;cell development#GO:0048468;cell projection organization#GO:0030030;cell differentiation#GO:0030154;sensory perception of sound#GO:0007605;sensory organ morphogenesis#GO:0090596;cell morphogenesis#GO:0000902;anatomical structure morphogenesis#GO:0009653;inner ear receptor cell stereocilium organization#GO:0060122;cellular component organization#GO:0016043;neuron development#GO:0048666;ear development#GO:0043583;generation of neurons#GO:0048699;nervous system process#GO:0050877;animal gross anatomical part developmental process#GO:0160108 membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;stereocilium#GO:0032420;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;actin cytoskeleton#GO:0015629;actin-based cell projection#GO:0098858;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cilium#GO:0005929;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;cluster of actin-based cell projections#GO:0098862;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085 HUMAN|HGNC=22467|UniProtKB=A6NGH8 A6NGH8 ANKRD61 PTHR24197:SF52 ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 61 ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 61 enzyme regulator activity#GO:0030234;protein kinase regulator activity#GO:0019887;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772 regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;regulation of cell communication#GO:0010646;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634 HUMAN|HGNC=10832|UniProtKB=Q99963 Q99963 SH3GL3 PTHR14167:SF45 SH3 DOMAIN-CONTAINING ENDOPHILIN-A3 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 intracellular anatomical structure#GO:0005622;cell junction#GO:0030054;cytoplasm#GO:0005737;glutamatergic synapse#GO:0098978;synapse#GO:0045202;cellular anatomical structure#GO:0110165;presynapse#GO:0098793;cytosol#GO:0005829 scaffold/adaptor protein#PC00226 Huntington disease#P00029>SH3GL3#P00813 HUMAN|HGNC=33280|UniProtKB=Q6ZU15 Q6ZU15 SEPTIN14 PTHR18884:SF51 SEPTIN SEPTIN-14 hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817 cellular process#GO:0009987;cell division#GO:0051301;cell cycle process#GO:0022402;macromolecule localization#GO:0033036;cell cycle#GO:0007049;intracellular protein localization#GO:0008104;cytoskeleton-dependent cytokinesis#GO:0061640;localization#GO:0051179;cytokinesis#GO:0000910 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cell division site#GO:0032153;microtubule cytoskeleton#GO:0015630;cell periphery#GO:0071944;cell cortex#GO:0005938 cytoskeletal protein#PC00085 HUMAN|HGNC=6766|UniProtKB=Q8WXG6 Q8WXG6 MADD PTHR13008:SF7 MAP-KINASE ACTIVATING DEATH DOMAIN PROTEIN MADD /DENN/AEX-3 C.ELEGANS MAP KINASE-ACTIVATING DEATH DOMAIN PROTEIN guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234 regulation of small GTPase mediated signal transduction#GO:0051056;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;regulation of apoptotic process#GO:0042981;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cell communication#GO:0010646;regulation of programmed cell death#GO:0043067;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 Apoptosis signaling pathway#P00006>MADD#P00267 HUMAN|HGNC=25623|UniProtKB=Q53HC5 Q53HC5 KLHL26 PTHR45632:SF13 LD33804P KELCH-LIKE PROTEIN 26 ubiquitin-like ligase-substrate adaptor activity#GO:1990756;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;enzyme-substrate adaptor activity#GO:0140767 proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152 catalytic complex#GO:1902494;transferase complex#GO:1990234;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535;Cul3-RING ubiquitin ligase complex#GO:0031463;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151 scaffold/adaptor protein#PC00226 HUMAN|HGNC=25615|UniProtKB=Q1X8D7 Q1X8D7 LRRC36 PTHR23311:SF6 HEAT SHOCK REGULATED 2 LEUCINE-RICH REPEAT-CONTAINING PROTEIN 36 HUMAN|HGNC=4041|UniProtKB=Q9NPG1 Q9NPG1 FZD3 PTHR11309:SF22 FRIZZLED FRIZZLED-3 molecular transducer activity#GO:0060089;protein binding#GO:0005515;Wnt-protein binding#GO:0017147;signaling receptor activity#GO:0038023;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888 cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;canonical Wnt signaling pathway#GO:0060070;non-canonical Wnt signaling pathway#GO:0035567;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;Wnt signaling pathway#GO:0016055;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 Cadherin signaling pathway#P00012>Frizzled#P00475;Angiogenesis#P00005>Fzd#P00189;Alzheimer disease-presenilin pathway#P00004>Frizzled#P00119;Angiogenesis#P00005>FRP#P00237;Wnt signaling pathway#P00057>Frizzled#P01428 HUMAN|HGNC=24010|UniProtKB=Q7Z4T9 Q7Z4T9 CFAP91 PTHR22455:SF10 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 91 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 91 HUMAN|HGNC=1074|UniProtKB=P18075 P18075 BMP7 PTHR11848:SF135 TGF-BETA FAMILY BONE MORPHOGENETIC PROTEIN 7 receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;cytokine activity#GO:0005125;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546 signaling#GO:0023052;response to stimulus#GO:0050896;response to growth factor#GO:0070848;cellular response to endogenous stimulus#GO:0071495;circulatory system development#GO:0072359;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;BMP signaling pathway#GO:0030509;cellular response to stimulus#GO:0051716;response to endogenous stimulus#GO:0009719;system development#GO:0048731;cellular response to growth factor stimulus#GO:0071363;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;animal gross anatomical part developmental process#GO:0160108;biological regulation#GO:0065007;heart development#GO:0007507;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;multicellular organismal process#GO:0032501;signal transduction#GO:0007165;cellular process#GO:0009987;multicellular organism development#GO:0007275;animal organ development#GO:0048513;cellular response to BMP stimulus#GO:0071773;response to BMP#GO:0071772;developmental process#GO:0032502;cell surface receptor signaling pathway#GO:0007166;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 growth factor#PC00112 Gonadotropin-releasing hormone receptor pathway#P06664>BMP7#G06687;Gonadotropin-releasing hormone receptor pathway#P06664>BMP7#G06901;Gonadotropin-releasing hormone receptor pathway#P06664>BMP6/7#P06752;TGF-beta signaling pathway#P00052>TGFbeta#P01286 HUMAN|HGNC=6332|UniProtKB=Q99706 Q99706 KIR2DL4 PTHR11738:SF197 MHC CLASS I NK CELL RECEPTOR KILLER CELL IMMUNOGLOBULIN-LIKE RECEPTOR 2DL4 transmembrane signaling receptor activity#GO:0004888;immune receptor activity#GO:0140375;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell communication#GO:0007154;regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166;regulation of immune response#GO:0050776;immune response-regulating cell surface receptor signaling pathway#GO:0002768;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;response to stimulus#GO:0050896;immune response-regulating signaling pathway#GO:0002764;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=17152|UniProtKB=Q9Y305 Q9Y305 ACOT9 PTHR12655:SF10 ACYL-COA THIOESTERASE ACYL-COENZYME A THIOESTERASE 9, MITOCHONDRIAL hydrolase activity#GO:0016787;acyl-CoA hydrolase activity#GO:0016289;catalytic activity#GO:0003824;fatty acyl-CoA hydrolase activity#GO:0047617;deacylase activity#GO:0160215;thiolester hydrolase activity#GO:0016790;hydrolase activity, acting on ester bonds#GO:0016788 nucleobase-containing compound metabolic process#GO:0006139;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;cellular process#GO:0009987;purine-containing compound metabolic process#GO:0072521;organophosphate metabolic process#GO:0019637;primary metabolic process#GO:0044238;sulfur compound metabolic process#GO:0006790;phosphorus metabolic process#GO:0006793;nucleobase-containing small molecule metabolic process#GO:0055086;acyl-CoA metabolic process#GO:0006637;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739 metabolite interconversion enzyme#PC00262;esterase#PC00097;hydrolase#PC00121 HUMAN|HGNC=21592|UniProtKB=Q7Z5A7 Q7Z5A7 TAFA5 PTHR31878:SF0 CHEMOKINE-LIKE PROTEIN TAFA-5-RELATED CHEMOKINE-LIKE PROTEIN TAFA-5 signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;G protein-coupled receptor binding#GO:0001664;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;molecular function activator activity#GO:0140677;protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 chemokine#PC00074;cytokine#PC00083 HUMAN|HGNC=29632|UniProtKB=Q8WZ59 Q8WZ59 TMEM190 PTHR37868:SF1 TRANSMEMBRANE PROTEIN 190 TRANSMEMBRANE PROTEIN 190 cellular process#GO:0009987;developmental process#GO:0032502;cell development#GO:0048468;hemopoiesis#GO:0030097;cellular developmental process#GO:0048869;anatomical structure development#GO:0048856;cell differentiation#GO:0030154 vesicle#GO:0031982;secretory granule membrane#GO:0030667;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;acrosomal vesicle#GO:0001669;membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;vesicle membrane#GO:0012506;secretory vesicle#GO:0099503;membrane#GO:0016020;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;acrosomal membrane#GO:0002080 HUMAN|HGNC=15965|UniProtKB=Q9NR90 Q9NR90 DAZ3 PTHR11176:SF8 BOULE-RELATED DELETED IN AZOOSPERMIA PROTEIN 1-RELATED translation regulator activity#GO:0045182 regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of translation#GO:0045727;negative regulation of catabolic process#GO:0009895;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;regulation of RNA stability#GO:0043487;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of gene expression#GO:0010628;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA catabolic process#GO:1902369;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;negative regulation of metabolic process#GO:0009892;regulation of mRNA stability#GO:0043488;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of biological quality#GO:0065008;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;RNA stabilization#GO:0043489;regulation of translational initiation#GO:0006446;positive regulation of protein metabolic process#GO:0051247;mRNA stabilization#GO:0048255;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;regulation of protein metabolic process#GO:0051246;regulation of mRNA metabolic process#GO:1903311;negative regulation of RNA metabolic process#GO:0051253 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031 HUMAN|HGNC=1704|UniProtKB=Q9UIB8 Q9UIB8 CD84 PTHR12080:SF103 SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE SLAM FAMILY MEMBER 5 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 immune system process#GO:0002376;cell activation#GO:0001775;cell communication#GO:0007154;T cell activation#GO:0042110;leukocyte activation#GO:0045321;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;cellular process#GO:0009987;signal transduction#GO:0007165;immune response#GO:0006955;multicellular organismal process#GO:0032501;lymphocyte activation#GO:0046649;biological regulation#GO:0065007 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=9381|UniProtKB=P22694 P22694 PRKACB PTHR24353:SF116 CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cell communication#GO:0007154 intracellular protein-containing complex#GO:0140535;protein kinase complex#GO:1902911;transferase complex#GO:1990234;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;nucleus#GO:0005634;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 GABA-B receptor II signaling#P05731>PKA#P05752;Beta2 adrenergic receptor signaling pathway#P04378>PKA#P04444;Endothelin signaling pathway#P00019>PKA#P00570;Dopamine receptor mediated signaling pathway#P05912>PKA#P05946;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>PKA#P00746;Metabotropic glutamate receptor group III pathway#P00039>PKA#P01035;Beta1 adrenergic receptor signaling pathway#P04377>PKA#P04437;Metabotropic glutamate receptor group I pathway#P00041>PKA#P01059;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PKA#P00862;Metabotropic glutamate receptor group II pathway#P00040>PKA#P01050;5HT1 type receptor mediated signaling pathway#P04373>PKA#P04403;Enkephalin release#P05913>PKA#P05972;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>PKA#P01075;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>PKA-c#P00707;Histamine H2 receptor mediated signaling pathway#P04386>PKA#P04491;CCKR signaling map#P06959>PKA-Calpha/beta/gamma#P07099 HUMAN|HGNC=8538|UniProtKB=O15547 O15547 P2RX6 PTHR10125:SF21 P2X PURINOCEPTOR P2X PURINOCEPTOR 6 monoatomic cation channel activity#GO:0005261;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;ligand-gated monoatomic cation channel activity#GO:0099094;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;gated channel activity#GO:0022836;ligand-gated monoatomic ion channel activity#GO:0015276 monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987;calcium ion transmembrane transport#GO:0070588;calcium ion transport#GO:0006816;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;transport#GO:0006810 membrane#GO:0016020;cell periphery#GO:0071944;cell junction#GO:0030054;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 ligand-gated ion channel#PC00141 HUMAN|HGNC=20661|UniProtKB=Q70HW3 Q70HW3 SLC25A26 PTHR45667:SF9 S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN MITOCHONDRIAL S-ADENOSYLMETHIONINE CARRIER PROTEIN transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 mitochondrial carrier protein#PC00158 HUMAN|HGNC=11009|UniProtKB=P14672 P14672 SLC2A4 PTHR23503:SF120 SOLUTE CARRIER FAMILY 2 SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 4 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;sugar transmembrane transporter activity#GO:0051119;carbohydrate transmembrane transporter activity#GO:0015144 response to nitrogen compound#GO:1901698;transmembrane transport#GO:0055085;localization#GO:0051179;response to oxygen-containing compound#GO:1901700;carbohydrate transport#GO:0008643;cellular response to chemical stimulus#GO:0070887;cellular response to peptide hormone stimulus#GO:0071375;vitamin transport#GO:0051180;cellular response to hormone stimulus#GO:0032870;response to stimulus#GO:0050896;import across plasma membrane#GO:0098739;cellular response to endogenous stimulus#GO:0071495;response to insulin#GO:0032868;cellular response to stimulus#GO:0051716;response to endogenous stimulus#GO:0009719;import into cell#GO:0098657;establishment of localization#GO:0051234;transport#GO:0006810;cellular response to insulin stimulus#GO:0032869;response to peptide hormone#GO:0043434;cellular response to nitrogen compound#GO:1901699;carbohydrate transmembrane transport#GO:0034219;response to chemical#GO:0042221;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;D-glucose transmembrane transport#GO:1904659;response to hormone#GO:0009725 intracellular anatomical structure#GO:0005622;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;perinuclear region of cytoplasm#GO:0048471;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 secondary carrier transporter#PC00258 HUMAN|HGNC=7707|UniProtKB=P28331 P28331 NDUFS1 PTHR11615:SF377 NITRATE, FORMATE, IRON DEHYDROGENASE NADH-UBIQUINONE OXIDOREDUCTASE 75 KDA SUBUNIT, MITOCHONDRIAL oxidoreductase activity, acting on NAD(P)H#GO:0016651;monoatomic cation transmembrane transporter activity#GO:0008324;electron transfer activity#GO:0009055;NADH dehydrogenase activity#GO:0003954;active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399;oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor#GO:0016655;monoatomic ion transmembrane transporter activity#GO:0015075;oxidoreductase activity#GO:0016491;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;proton transmembrane transporter activity#GO:0015078;catalytic activity#GO:0003824 mitochondrial ATP synthesis coupled electron transport#GO:0042775;cellular process#GO:0009987;respiratory electron transport chain#GO:0022904;electron transport chain#GO:0022900;aerobic respiration#GO:0009060;oxidative phosphorylation#GO:0006119;ATP synthesis coupled electron transport#GO:0042773;cellular respiration#GO:0045333;energy derivation by oxidation of organic compounds#GO:0015980;generation of precursor metabolites and energy#GO:0006091;mitochondrial electron transport, NADH to ubiquinone#GO:0006120;metabolic process#GO:0008152;aerobic electron transport chain#GO:0019646 mitochondrial membrane#GO:0031966;respiratory chain complex#GO:0098803;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;mitochondrial inner membrane#GO:0005743;oxidoreductase complex#GO:1990204;membrane#GO:0016020;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;respiratory chain complex I#GO:0045271;organelle membrane#GO:0031090;transporter complex#GO:1990351;mitochondrion#GO:0005739;membrane protein complex#GO:0098796;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;transmembrane transporter complex#GO:1902495 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=17992|UniProtKB=Q9HCF6 Q9HCF6 TRPM3 PTHR13800:SF7 TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6 TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 3 metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic cation channel activity#GO:0005261;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;passive transmembrane transporter activity#GO:0022803;calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267 metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;calcium ion transport#GO:0006816;monoatomic ion transport#GO:0006811;transport#GO:0006810 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133;transporter#PC00227 HUMAN|HGNC=11388|UniProtKB=O94804 O94804 STK10 PTHR48012:SF31 STERILE20-LIKE KINASE, ISOFORM B-RELATED SERINE_THREONINE-PROTEIN KINASE 10 catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signaling#GO:0023052;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;response to stimulus#GO:0050896;regulation of leukocyte migration#GO:0002685;regulation of lymphocyte migration#GO:2000401;intracellular signal transduction#GO:0035556;regulation of cell motility#GO:2000145;cell communication#GO:0007154;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of locomotion#GO:0040012;biological regulation#GO:0065007;regulation of cell migration#GO:0030334 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=10062|UniProtKB=Q5VTR2 Q5VTR2 RNF20 PTHR23163:SF2 RING FINGER PROTEIN-RELATED E3 UBIQUITIN-PROTEIN LIGASE BRE1A aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746 chromatin#GO:0000785;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;transferase complex#GO:1990234;membraneless organelle#GO:0043228;intracellular protein-containing complex#GO:0140535;chromosome#GO:0005694;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ubiquitin ligase complex#GO:0000151;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=9173|UniProtKB=P09884 P09884 POLA1 PTHR45861:SF1 DNA POLYMERASE ALPHA CATALYTIC SUBUNIT DNA POLYMERASE ALPHA CATALYTIC SUBUNIT sequence-specific double-stranded DNA binding#GO:1990837;catalytic activity, acting on a nucleic acid#GO:0140640;nucleotidyltransferase activity#GO:0016779;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-directed DNA polymerase activity#GO:0003887;nucleic acid binding#GO:0003676;chromatin binding#GO:0003682;catalytic activity, acting on DNA#GO:0140097;DNA polymerase activity#GO:0034061;sequence-specific DNA binding#GO:0043565;transferase activity#GO:0016740;DNA replication origin binding#GO:0003688;binding#GO:0005488;single-stranded DNA binding#GO:0003697 nucleic acid biosynthetic process#GO:0141187;cellular response to stress#GO:0033554;DNA-templated DNA replication#GO:0006261;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;DNA replication#GO:0006260;response to stimulus#GO:0050896;DNA strand elongation involved in DNA replication#GO:0006271;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;nucleobase-containing compound biosynthetic process#GO:0034654;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;response to stress#GO:0006950;DNA biosynthetic process#GO:0071897;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139 membrane-enclosed lumen#GO:0031974;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;protein-containing complex#GO:0032991;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;DNA polymerase complex#GO:0042575;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;intracellular protein-containing complex#GO:0140535;organelle lumen#GO:0043233;chromosome#GO:0005694;replisome#GO:0030894;nuclear DNA-directed RNA polymerase complex#GO:0055029;replication fork#GO:0005657;nucleoplasm#GO:0005654;protein-DNA complex#GO:0032993;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;nuclear replication fork#GO:0043596;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428 DNA metabolism protein#PC00009 DNA replication#P00017>Pol alpha#P00531 HUMAN|HGNC=33826|UniProtKB=Q6P1X6 Q6P1X6 C8orf82 PTHR31449:SF3 UPF0598 PROTEIN C8ORF82 UPF0598 PROTEIN C8ORF82 HUMAN|HGNC=26931|UniProtKB=O95567 O95567 C22orf31 PTHR15578:SF0 CHROMOSOME 8 C22ORF31 HOMOLOG CHROMOSOME 22 OPEN READING FRAME 31 HUMAN|HGNC=11339|UniProtKB=O60225 O60225 SSX5 PTHR14112:SF23 SYNOVIAL SARCOMA, X MEMBER PROTEIN SSX5 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 transcription cofactor#PC00217;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=2594|UniProtKB=P11511 P11511 CYP19A1 PTHR24291:SF43 CYTOCHROME P450 FAMILY 4 AROMATASE oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824;monooxygenase activity#GO:0004497;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen#GO:0016712 developmental process involved in reproduction#GO:0003006;reproductive structure development#GO:0048608;reproductive process#GO:0022414;response to stimulus#GO:0050896;response to oxygen-containing compound#GO:1901700;animal gross anatomical part developmental process#GO:0160108;female gonad development#GO:0008585;system development#GO:0048731;reproductive system development#GO:0061458;anatomical structure development#GO:0048856;sex differentiation#GO:0007548;response to estradiol#GO:0032355;gonad development#GO:0008406;response to chemical#GO:0042221;multicellular organismal process#GO:0032501;response to lipid#GO:0033993;developmental process#GO:0032502;development of primary sexual characteristics#GO:0045137;multicellular organism development#GO:0007275;animal organ development#GO:0048513 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262;oxygenase#PC00177 Androgen/estrogene/progesterone biosynthesis#P02727>Aromatase#P02828 HUMAN|HGNC=24776|UniProtKB=Q3KNS1 Q3KNS1 PTCHD3 PTHR10796:SF60 PATCHED-RELATED PATCHED DOMAIN-CONTAINING PROTEIN 3 membrane#GO:0016020;cellular anatomical structure#GO:0110165 protein-binding activity modulator#PC00095 HUMAN|HGNC=5744|UniProtKB=A0A0C4DH69 A0A0C4DH69 IGKV1-9 PTHR23267:SF539 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN KAPPA VARIABLE 1-9-RELATED response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=1065|UniProtKB=Q9H2G9 Q9H2G9 BLZF1 PTHR13066:SF2 BASIC LEUCINE ZIPPER NUCLEAR FACTOR 1 BLZF1 PROTEIN GOLGIN-45 Golgi vesicle transport#GO:0048193;transport#GO:0006810;protein localization to cell periphery#GO:1990778;intracellular protein localization#GO:0008104;vesicle-mediated transport to the plasma membrane#GO:0098876;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of protein localization to membrane#GO:0090150;macromolecule localization#GO:0033036;organelle organization#GO:0006996;endomembrane system organization#GO:0010256;vesicle-mediated transport#GO:0016192;establishment of protein localization to plasma membrane#GO:0061951;localization within membrane#GO:0051668;protein transport#GO:0015031;post-Golgi vesicle-mediated transport#GO:0006892;cellular localization#GO:0051641;localization#GO:0051179;Golgi organization#GO:0007030;cellular component organization#GO:0016043;protein localization to plasma membrane#GO:0072659;protein localization to membrane#GO:0072657;Golgi to plasma membrane protein transport#GO:0043001;Golgi to plasma membrane transport#GO:0006893 Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane#GO:0016020;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 basic leucine zipper transcription factor#PC00056;DNA-binding transcription factor#PC00218 HUMAN|HGNC=26168|UniProtKB=Q9H6L4 Q9H6L4 ARMC7 PTHR46263:SF1 ARMADILLO REPEAT-CONTAINING PROTEIN 7 ARMADILLO REPEAT-CONTAINING PROTEIN 7 HUMAN|HGNC=10437|UniProtKB=Q9UBS0 Q9UBS0 RPS6KB2 PTHR24351:SF171 RIBOSOMAL PROTEIN S6 KINASE RIBOSOMAL PROTEIN S6 KINASE BETA-2 protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;TORC1 signaling#GO:0038202;biological regulation#GO:0065007;signaling#GO:0023052;TOR signaling#GO:0031929;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 PI3 kinase pathway#P00048>S6K#P01194;PDGF signaling pathway#P00047>p90RSK#P01142;p53 pathway by glucose deprivation#P04397>S6K#P04636;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>P90 RSK#P00888 HUMAN|HGNC=14669|UniProtKB=P81605 P81605 DCD PTHR40711:SF1 DERMCIDIN-RELATED DERMCIDIN defense response#GO:0006952;response to external stimulus#GO:0009605;humoral immune response#GO:0006959;antimicrobial humoral response#GO:0019730;defense response to other organism#GO:0098542;response to other organism#GO:0051707;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;immune response#GO:0006955;defense response to symbiont#GO:0140546;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;immune system process#GO:0002376;response to bacterium#GO:0009617;defense response to bacterium#GO:0042742;response to stimulus#GO:0050896;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=3629|UniProtKB=P37268 P37268 FDFT1 PTHR11626:SF8 FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE SQUALENE SYNTHASE prenyltransferase activity#GO:0004659;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;catalytic activity#GO:0003824;transferase activity#GO:0016740 isoprenoid metabolic process#GO:0006720;terpenoid metabolic process#GO:0006721;secondary alcohol metabolic process#GO:1902652;phospholipid metabolic process#GO:0006644;small molecule metabolic process#GO:0044281;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;secondary alcohol biosynthetic process#GO:1902653;sterol metabolic process#GO:0016125;steroid biosynthetic process#GO:0006694;cholesterol metabolic process#GO:0008203;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;alcohol metabolic process#GO:0006066;biosynthetic process#GO:0009058;sterol biosynthetic process#GO:0016126;steroid metabolic process#GO:0008202;cholesterol biosynthetic process#GO:0006695;lipid biosynthetic process#GO:0008610;alcohol biosynthetic process#GO:0046165;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637 organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum membrane#GO:0005789;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;membrane#GO:0016020 transferase#PC00220 Cholesterol biosynthesis#P00014>Farnesyl-diphosphate farnesyltransferase#P00499 HUMAN|HGNC=2854|UniProtKB=Q86XP1 Q86XP1 DGKH PTHR11255:SF37 DIACYLGLYCEROL KINASE DIACYLGLYCEROL KINASE ETA lipid kinase activity#GO:0001727;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phospholipid metabolic process#GO:0006644;signaling#GO:0023052;phospholipid biosynthetic process#GO:0008654;regulation of cellular process#GO:0050794;glycerolipid metabolic process#GO:0046486;response to stimulus#GO:0050896;intracellular signal transduction#GO:0035556;organophosphate biosynthetic process#GO:0090407;cell communication#GO:0007154;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;signal transduction#GO:0007165;organophosphate metabolic process#GO:0019637;biosynthetic process#GO:0009058;biological regulation#GO:0065007;lipid biosynthetic process#GO:0008610;glycerophospholipid metabolic process#GO:0006650;lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474;acylglycerol metabolic process#GO:0006639;metabolic process#GO:0008152;neutral lipid metabolic process#GO:0006638 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 kinase#PC00137;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=14378|UniProtKB=Q9NPE3 Q9NPE3 NOP10 PTHR13305:SF0 RIBOSOME BIOGENESIS PROTEIN NOP10 H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 3 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;rRNA modification#GO:0000154;pseudouridine synthesis#GO:0001522;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;snRNA metabolic process#GO:0016073;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;ribosome biogenesis#GO:0042254;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;snRNA processing#GO:0016180;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072 organelle lumen#GO:0043233;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;sno(s)RNA-containing ribonucleoprotein complex#GO:0005732;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228 RNA metabolism protein#PC00031 HUMAN|HGNC=20411|UniProtKB=Q7Z794 Q7Z794 KRT77 PTHR45616:SF24 GATA-TYPE DOMAIN-CONTAINING PROTEIN KERATIN, TYPE II CYTOSKELETAL 1B structural molecule activity#GO:0005198 cell differentiation#GO:0030154;intermediate filament cytoskeleton organization#GO:0045104;cellular component organization#GO:0016043;anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;intermediate filament-based process#GO:0045103;keratinocyte differentiation#GO:0030216;animal gross anatomical part developmental process#GO:0160108;intermediate filament organization#GO:0045109;epithelium development#GO:0060429;epidermal cell differentiation#GO:0009913;tissue development#GO:0009888;multicellular organismal process#GO:0032501;epithelial cell differentiation#GO:0030855;skin development#GO:0043588;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;animal organ development#GO:0048513;cellular developmental process#GO:0048869;epidermis development#GO:0008544;developmental process#GO:0032502 intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intermediate filament#GO:0005882;supramolecular fiber#GO:0099512;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 HUMAN|HGNC=12134|UniProtKB=P0DPF4 P0DPF4 TRAV35 PTHR19433:SF119 T-CELL RECEPTOR ALPHA CHAIN V REGION-RELATED T CELL RECEPTOR ALPHA VARIABLE 35 response to biotic stimulus#GO:0009607;response to bacterium#GO:0009617;response to other organism#GO:0051707;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to external stimulus#GO:0009605;response to stimulus#GO:0050896 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=25158|UniProtKB=Q96ER3 Q96ER3 SAAL1 PTHR23424:SF35 SERUM AMYLOID A PROTEIN SAAL1 regulation of cell population proliferation#GO:0042127;positive regulation of cell population proliferation#GO:0008284;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;positive regulation of epithelial cell proliferation#GO:0050679;biological regulation#GO:0065007 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 apolipoprotein#PC00052;transfer/carrier protein#PC00219 HUMAN|HGNC=406|UniProtKB=P30038 P30038 ALDH4A1 PTHR14516:SF3 1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE FAMILY MEMBER DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE, MITOCHONDRIAL oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the aldehyde or oxo group of donors#GO:0016903;catalytic activity#GO:0003824;oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor#GO:0016620;aldehyde dehydrogenase (NAD+) activity#GO:0004029 oxidoreductase#PC00176;dehydrogenase#PC00092 5-Hydroxytryptamine degredation#P04372>Aldehyde Dehydrogenase#P04402 HUMAN|HGNC=25581|UniProtKB=A0AVT1 A0AVT1 UBA6 PTHR10953:SF186 UBIQUITIN-ACTIVATING ENZYME E1 UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 6 ATP-dependent activity#GO:0140657;ligase activity, forming carbon-sulfur bonds#GO:0016877;transferase activity, transferring sulphur-containing groups#GO:0016782;thiosulfate-cyanide sulfurtransferase activity#GO:0004792;sulfurtransferase activity#GO:0016783;ligase activity#GO:0016874;transferase activity, transferring phosphorus-containing groups#GO:0016772;ubiquitin-like modifier activating enzyme activity#GO:0008641;nucleotidyltransferase activity#GO:0016779;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;protein modification process#GO:0036211;primary metabolic process#GO:0044238;cellular process#GO:0009987;protein modification by small protein conjugation#GO:0032446;post-translational protein modification#GO:0043687 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 Ubiquitin proteasome pathway#P00060>E1#P01492 HUMAN|HGNC=11150|UniProtKB=P08621 P08621 SNRNP70 PTHR13952:SF5 U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KD U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KDA RNA binding#GO:0003723;snRNA binding#GO:0017069;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;mRNA splicing, via spliceosome#GO:0000398;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397 spliceosomal snRNP complex#GO:0097525;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;precatalytic spliceosome#GO:0071011;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;U2-type prespliceosome#GO:0071004;U2-type spliceosomal complex#GO:0005684;intracellular membrane-bounded organelle#GO:0043231;spliceosomal complex#GO:0005681;nuclear protein-containing complex#GO:0140513;Sm-like protein family complex#GO:0120114;U1 snRNP#GO:0005685;protein-containing complex#GO:0032991;small nuclear ribonucleoprotein complex#GO:0030532;nucleus#GO:0005634 RNA splicing factor#PC00148 HUMAN|HGNC=8734|UniProtKB=Q9BW27 Q9BW27 NUP85 PTHR13373:SF21 FROUNT PROTEIN-RELATED NUCLEAR PORE COMPLEX PROTEIN NUP85 structural constituent of nuclear pore#GO:0017056;structural molecule activity#GO:0005198 macromolecule metabolic process#GO:0043170;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;transport#GO:0006810;biosynthetic process#GO:0009058;import into nucleus#GO:0051170;macromolecule localization#GO:0033036;protein localization to nucleus#GO:0034504;nitrogen compound transport#GO:0071705;macromolecule biosynthetic process#GO:0009059;localization#GO:0051179;nucleic acid transport#GO:0050657;nuclear transport#GO:0051169;nuclear export#GO:0051168;nucleocytoplasmic transport#GO:0006913;nucleobase-containing compound transport#GO:0015931;RNA localization#GO:0006403;protein localization to organelle#GO:0033365;RNA transport#GO:0050658;establishment of RNA localization#GO:0051236;mRNA transport#GO:0051028;metabolic process#GO:0008152;intracellular protein transport#GO:0006886;gene expression#GO:0010467;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;protein transport#GO:0015031;protein import into nucleus#GO:0006606 organelle envelope#GO:0031967;nuclear pore outer ring#GO:0031080;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear pore#GO:0005643 structural protein#PC00211 HUMAN|HGNC=10471|UniProtKB=Q01196 Q01196 RUNX1 PTHR11950:SF40 RUNT RELATED RUNT-RELATED TRANSCRIPTION FACTOR 1 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 nervous system development#GO:0007399;cellular process#GO:0009987;animal organ development#GO:0048513;multicellular organism development#GO:0007275;neuron differentiation#GO:0030182;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;cell development#GO:0048468;regulation of biological process#GO:0050789;skeletal system development#GO:0001501;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;tissue development#GO:0009888;multicellular organismal process#GO:0032501;chondrocyte differentiation#GO:0002062;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;hemopoiesis#GO:0030097;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;connective tissue development#GO:0061448;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;regulation of cell differentiation#GO:0045595;developmental process#GO:0032502;ossification#GO:0001503;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of developmental process#GO:0050793;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;cartilage development#GO:0051216;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 DNA-binding transcription factor#PC00218;Runt transcription factor#PC00254 HUMAN|HGNC=2914|UniProtKB=P56177 P56177 DLX1 PTHR24327:SF33 HOMEOBOX PROTEIN HOMEOBOX PROTEIN DLX-1 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 embryo development#GO:0009790;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;multicellular organism development#GO:0007275;developmental process#GO:0032502;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;skeletal system development#GO:0001501;embryo development ending in birth or egg hatching#GO:0009792;animal gross anatomical part developmental process#GO:0160108;chordate embryonic development#GO:0043009 gene-specific transcriptional regulator#PC00264;helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=25595|UniProtKB=Q5T7N2 Q5T7N2 L1TD1 PTHR11505:SF203 L1 TRANSPOSABLE ELEMENT-RELATED LINE-1 TYPE TRANSPOSASE DOMAIN-CONTAINING PROTEIN 1 cellular process#GO:0009987 protein-containing complex#GO:0032991;ribonucleoprotein complex#GO:1990904 viral or transposable element protein#PC00237 HUMAN|HGNC=4944|UniProtKB=P01920 P01920 HLA-DQB1 PTHR19944:SF99 MHC CLASS II-RELATED HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DQ BETA 1 CHAIN peptide binding#GO:0042277;antigen binding#GO:0003823;binding#GO:0005488;protein-containing complex binding#GO:0044877 immune system process#GO:0002376;regulation of lymphocyte activation#GO:0051249;regulation of leukocyte activation#GO:0002694;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;regulation of biological process#GO:0050789;positive regulation of multicellular organismal process#GO:0051240;regulation of cell activation#GO:0050865;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;positive regulation of leukocyte activation#GO:0002696;positive regulation of T cell activation#GO:0050870;cellular component assembly#GO:0022607;regulation of T cell activation#GO:0050863;regulation of multicellular organismal process#GO:0051239;positive regulation of cell-cell adhesion#GO:0022409;cellular component biogenesis#GO:0044085;positive regulation of immune system process#GO:0002684;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of lymphocyte activation#GO:0051251;antigen processing and presentation#GO:0019882;regulation of immune response#GO:0050776;regulation of cell-cell adhesion#GO:0022407;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;positive regulation of cell adhesion#GO:0045785;regulation of leukocyte cell-cell adhesion#GO:1903037;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;positive regulation of response to stimulus#GO:0048584;regulation of cell adhesion#GO:0030155;biological regulation#GO:0065007;positive regulation of leukocyte cell-cell adhesion#GO:1903039;positive regulation of cell activation#GO:0050867;positive regulation of cellular process#GO:0048522 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;lytic vacuole membrane#GO:0098852;lysosome#GO:0005764;plasma membrane protein complex#GO:0098797;vesicle#GO:0031982;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endosome membrane#GO:0010008;endosome#GO:0005768;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;late endosome#GO:0005770;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;cytoplasm#GO:0005737;plasma membrane#GO:0005886;vacuole#GO:0005773;membrane#GO:0016020;vesicle membrane#GO:0012506;lysosomal membrane#GO:0005765;cell periphery#GO:0071944;vacuolar membrane#GO:0005774;lytic vacuole#GO:0000323;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;late endosome membrane#GO:0031902 major histocompatibility complex protein#PC00149 HUMAN|HGNC=1540|UniProtKB=P08185 P08185 SERPINA6 PTHR11461:SF34 SERINE PROTEASE INHIBITOR, SERPIN CORTICOSTEROID-BINDING GLOBULIN enzyme inhibitor activity#GO:0004857;molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866;peptidase regulator activity#GO:0061134;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;serine-type endopeptidase inhibitor activity#GO:0004867;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease inhibitor#PC00191 HUMAN|HGNC=31397|UniProtKB=Q6UWY2 Q6UWY2 PRSS57 PTHR24271:SF55 KALLIKREIN-RELATED SERINE PROTEASE 57 hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;serine-type peptidase activity#GO:0008236;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity#GO:0003824 metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 serine protease#PC00203 HUMAN|HGNC=1096|UniProtKB=O95861 O95861 BPNT1 PTHR43028:SF5 3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1 3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1 nucleotidase activity#GO:0008252;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 phosphatase#PC00181;hydrolase#PC00121 HUMAN|HGNC=26470|UniProtKB=Q8IW00 Q8IW00 VSTM4 PTHR12207:SF8 V-SET AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN V-SET AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 4 membrane#GO:0016020;cellular anatomical structure#GO:0110165 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=26151|UniProtKB=Q9H6T3 Q9H6T3 RPAP3 PTHR46423:SF1 RNA POLYMERASE II-ASSOCIATED PROTEIN 3 RNA POLYMERASE II-ASSOCIATED PROTEIN 3 HUMAN|HGNC=25248|UniProtKB=Q9H0B8 Q9H0B8 CRISPLD2 PTHR10334:SF64 CYSTEINE-RICH SECRETORY PROTEIN-RELATED CYSTEINE-RICH SECRETORY PROTEIN LCCL DOMAIN-CONTAINING 2 binding#GO:0005488;glycosaminoglycan binding#GO:0005539;carbohydrate derivative binding#GO:0097367 animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;head development#GO:0060322 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090 HUMAN|HGNC=16878|UniProtKB=P42694 P42694 HELZ PTHR10887:SF365 DNA2/NAM7 HELICASE FAMILY ATP-DEPENDENT RNA HELICASE WITH ZINC FINGER DOMAIN nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;regulatory ncRNA-mediated gene silencing#GO:0031047;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;regulatory ncRNA-mediated post-transcriptional gene silencing#GO:0035194;post-transcriptional gene silencing#GO:0016441 cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;supramolecular complex#GO:0099080;organelle#GO:0043226;ribonucleoprotein granule#GO:0035770;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytosol#GO:0005829;membraneless organelle#GO:0043228;P granule#GO:0043186;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 RNA helicase#PC00032 HUMAN|HGNC=7806|UniProtKB=Q13952 Q13952 NFYC PTHR10252:SF91 HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT GAMMA sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 intracellular anatomical structure#GO:0005622;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575 DNA-binding transcription factor#PC00218 HUMAN|HGNC=21561|UniProtKB=Q8IYX8 Q8IYX8 CEP57L1 PTHR19336:SF10 UNCHARACTERIZED DUF1167 CENTROSOMAL PROTEIN CEP57L1 microtubule binding#GO:0008017;protein-macromolecule adaptor activity#GO:0030674;binding#GO:0005488;protein binding#GO:0005515;molecular adaptor activity#GO:0060090;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;cytoskeletal adaptor activity#GO:0008093 chromosome localization#GO:0050000;cytoskeleton organization#GO:0007010;cellular process#GO:0009987;attachment of spindle microtubules to kinetochore#GO:0008608;organelle organization#GO:0006996;microtubule-based process#GO:0007017;mitotic cell cycle process#GO:1903047;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;chromosome segregation#GO:0007059;metaphase chromosome alignment#GO:0051310;mitotic spindle organization#GO:0007052;mitotic cell cycle#GO:0000278;cell cycle process#GO:0022402;cellular component organization#GO:0016043;nuclear chromosome segregation#GO:0098813;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cell cycle#GO:0007049;microtubule cytoskeleton organization#GO:0000226;localization#GO:0051179;organelle localization#GO:0051640 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;microtubule#GO:0005874;spindle microtubule#GO:0005876;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule cytoskeleton#GO:0015630;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232;spindle#GO:0005819;microtubule organizing center#GO:0005815;centrosome#GO:0005813;cytoskeleton#GO:0005856;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228 HUMAN|HGNC=13353|UniProtKB=Q9BXW4 Q9BXW4 MAP1LC3C PTHR10969:SF50 MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED MICROTUBULE-ASSOCIATED PROTEIN 1 LIGHT CHAIN 3 GAMMA protein binding#GO:0005515;lipid binding#GO:0008289;ubiquitin protein ligase binding#GO:0031625;phospholipid binding#GO:0005543;binding#GO:0005488;ubiquitin-like protein ligase binding#GO:0044389;enzyme binding#GO:0019899 cellular response to nutrient levels#GO:0031669;metabolic process#GO:0008152;cellular response to starvation#GO:0009267;autophagosome maturation#GO:0097352;autophagy of mitochondrion#GO:0000422;autophagosome assembly#GO:0000045;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;mitophagy#GO:0000423;autophagy#GO:0006914;cellular process#GO:0009987;autophagosome organization#GO:1905037;organelle organization#GO:0006996;response to nutrient levels#GO:0031667;cellular component biogenesis#GO:0044085;response to stress#GO:0006950;macroautophagy#GO:0016236;cellular component assembly#GO:0022607;cellular response to stress#GO:0033554;organelle assembly#GO:0070925;vacuole organization#GO:0007033;process utilizing autophagic mechanism#GO:0061919;cellular component disassembly#GO:0022411;cellular response to stimulus#GO:0051716;response to starvation#GO:0042594;cellular component organization#GO:0016043;protein-containing complex disassembly#GO:0032984;response to stimulus#GO:0050896;catabolic process#GO:0009056 membrane#GO:0016020;vacuole#GO:0005773;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;autophagosome#GO:0005776;membrane-bounded organelle#GO:0043227;autophagosome membrane#GO:0000421;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;vacuolar membrane#GO:0005774 microtubule or microtubule-binding cytoskeletal protein#PC00157;cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HUMAN|HGNC=25640|UniProtKB=Q9NUQ7 Q9NUQ7 UFSP2 PTHR48153:SF6 UFM1-SPECIFIC PROTEASE 2 UFM1-SPECIFIC PROTEASE 2 hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;proteolysis#GO:0006508;primary metabolic process#GO:0044238;cellular process#GO:0009987 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 HUMAN|HGNC=4762|UniProtKB=P57053 P57053 H2BC12L PTHR23428:SF401 HISTONE H2B HISTONE H2B TYPE F-S antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;defense response to bacterium#GO:0042742;response to bacterium#GO:0009617;immune system process#GO:0002376;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;defense response#GO:0006952;response to external stimulus#GO:0009605;innate immune response#GO:0045087;antibacterial humoral response#GO:0019731;antimicrobial humoral response#GO:0019730;humoral immune response#GO:0006959;response to other organism#GO:0051707;defense response to other organism#GO:0098542;immune response#GO:0006955;defense response to symbiont#GO:0140546;response to stress#GO:0006950;response to biotic stimulus#GO:0009607 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=15782|UniProtKB=Q3KRB8 Q3KRB8 ARHGAP11B PTHR15670:SF4 RHO GTPASE ACTIVATING PROTEIN 11A INACTIVE RHO GTPASE-ACTIVATING PROTEIN 11B-RELATED enzyme activator activity#GO:0008047;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234 GTPase-activating protein#PC00257 HUMAN|HGNC=21528|UniProtKB=Q9NR28 Q9NR28 DIABLO PTHR32247:SF3 DIABLO HOMOLOG, MITOCHONDRIAL DIABLO IAP-BINDING MITOCHONDRIAL PROTEIN intrinsic apoptotic signaling pathway#GO:0097193;neuron apoptotic process#GO:0051402;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;programmed cell death#GO:0012501;cell death#GO:0008219;apoptotic process#GO:0006915;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;apoptotic signaling pathway#GO:0097190;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165 mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 Apoptosis signaling pathway#P00006>Smac/Diablo#P00309 HUMAN|HGNC=23495|UniProtKB=Q5T2Q4 Q5T2Q4 CCNYL2 PTHR14248:SF25 CYCLIN Y, ISOFORM A CYCLIN-Y-LIKE PROTEIN 2 cyclin-dependent protein kinase regulator activity#GO:0019914;protein kinase regulator activity#GO:0019887;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;protein kinase activator activity#GO:0030295;cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538;protein serine/threonine kinase activator activity#GO:0043539;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;kinase activator activity#GO:0019209 regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of canonical Wnt signaling pathway#GO:0060828;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HUMAN|HGNC=20765|UniProtKB=Q6PEY2 Q6PEY2 TUBA3E PTHR11588:SF322 TUBULIN TUBULIN ALPHA-3C CHAIN-RELATED ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;structural molecule activity#GO:0005198;nucleotide binding#GO:0000166;nucleoside phosphate binding#GO:1901265;structural constituent of cytoskeleton#GO:0005200;binding#GO:0005488;guanyl nucleotide binding#GO:0019001;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;ribonucleotide binding#GO:0032553;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555 organelle organization#GO:0006996;cell cycle#GO:0007049;cellular component organization#GO:0016043;cellular process#GO:0009987;mitotic cell cycle#GO:0000278;cytoskeleton organization#GO:0007010;cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226;microtubule-based process#GO:0007017 membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630 tubulin#PC00228;cytoskeletal protein#PC00085 HUMAN|HGNC=4740|UniProtKB=O75367 O75367 MACROH2A1 PTHR23430:SF20 HISTONE H2A CORE HISTONE MACRO-H2A.1 structural molecule activity#GO:0005198 regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;cellular component assembly#GO:0022607;heterochromatin organization#GO:0070828;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;negative regulation of gene expression, epigenetic#GO:0045814;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;heterochromatin formation#GO:0031507;regulation of DNA-templated transcription#GO:0006355;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;regulation of transcription by RNA polymerase I#GO:0006356;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;epigenetic regulation of gene expression#GO:0040029;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;protein-DNA complex#GO:0032993;intracellular membrane-bounded organelle#GO:0043231;nucleosome#GO:0000786;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694;chromatin#GO:0000785;nucleus#GO:0005634 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=6702|UniProtKB=Q32MZ4 Q32MZ4 LRRFIP1 PTHR19212:SF5 LEUCINE RICH REPEAT IN FLII INTERACTING PROTEIN LEUCINE-RICH REPEAT FLIGHTLESS-INTERACTING PROTEIN 1 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=28407|UniProtKB=Q96HI0 Q96HI0 SENP5 PTHR12606:SF10 SENTRIN/SUMO-SPECIFIC PROTEASE SENTRIN-SPECIFIC PROTEASE 5 hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824 protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein modification process#GO:0036211;post-translational protein modification#GO:0043687 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 protease#PC00190 HUMAN|HGNC=13013|UniProtKB=Q92794 Q92794 KAT6A PTHR10615:SF26 HISTONE ACETYLTRANSFERASE HISTONE ACETYLTRANSFERASE KAT6A histone modifying activity#GO:0140993;protein N-acyltransferase activity#GO:0140186;transcription regulator activity#GO:0140110;binding#GO:0005488;acetyltransferase activity#GO:0016407;protein N-acetyltransferase activity#GO:0034212;transferase activity#GO:0016740;histone acetyltransferase activity#GO:0004402;chromatin binding#GO:0003682;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;protein-lysine-acetyltransferase activity#GO:0061733;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity, acting on a protein#GO:0140096;transcription coregulator activity#GO:0003712;catalytic activity#GO:0003824 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 chromatin#GO:0000785;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;transferase complex#GO:1990234;membraneless organelle#GO:0043228;histone acetyltransferase complex#GO:0000123;intracellular protein-containing complex#GO:0140535;chromosome#GO:0005694;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;protein acetyltransferase complex#GO:0031248;membrane-bounded organelle#GO:0043227;acetyltransferase complex#GO:1902493;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077;histone modifying enzyme#PC00261 HUMAN|HGNC=25777|UniProtKB=Q2KHR2 Q2KHR2 RFX7 PTHR12619:SF2 RFX TRANSCRIPTION FACTOR FAMILY DNA-BINDING PROTEIN RFX7 RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 winged helix/forkhead transcription factor#PC00246 HUMAN|HGNC=21773|UniProtKB=Q5W064 Q5W064 LIPJ PTHR11005:SF11 LYSOSOMAL ACID LIPASE-RELATED LIPASE MEMBER J hydrolase activity#GO:0016787;catalytic activity#GO:0003824;lipase activity#GO:0016298;hydrolase activity, acting on ester bonds#GO:0016788 lipid metabolic process#GO:0006629;cellular process#GO:0009987;metabolic process#GO:0008152;primary metabolic process#GO:0044238 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 hydrolase#PC00121;lipase#PC00143 HUMAN|HGNC=2530|UniProtKB=P14091 P14091 CTSE PTHR47966:SF26 BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED CATHEPSIN E catalytic activity#GO:0003824;aspartic-type endopeptidase activity#GO:0004190;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175 immune system process#GO:0002376;proteolysis#GO:0006508;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;antigen processing and presentation#GO:0019882;primary metabolic process#GO:0044238;cellular process#GO:0009987 intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 protease#PC00190;aspartic protease#PC00053 HUMAN|HGNC=6414|UniProtKB=Q99456 Q99456 KRT12 PTHR23239:SF369 INTERMEDIATE FILAMENT KERATIN, TYPE I CYTOSKELETAL 12 structural molecule activity#GO:0005198 developmental process#GO:0032502;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;morphogenesis of an epithelium#GO:0002009;organelle organization#GO:0006996;cellular process#GO:0009987;epithelium development#GO:0060429;tissue development#GO:0009888;epithelial cell differentiation#GO:0030855;cytoskeleton organization#GO:0007010;intermediate filament-based process#GO:0045103;animal gross anatomical part developmental process#GO:0160108;intermediate filament organization#GO:0045109;tissue morphogenesis#GO:0048729;anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cell differentiation#GO:0030154;intermediate filament cytoskeleton organization#GO:0045104 intermediate filament#GO:0005882;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;supramolecular complex#GO:0099080;organelle#GO:0043226;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165 intermediate filament#PC00129 HUMAN|HGNC=6724|UniProtKB=P51884 P51884 LUM PTHR45712:SF6 AGAP008170-PA LUMICAN collagen binding#GO:0005518;binding#GO:0005488;protein-containing complex binding#GO:0044877 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=23516|UniProtKB=Q96B45 Q96B45 BORCS7 PTHR31397:SF1 BLOC-1-RELATED COMPLEX SUBUNIT 7 BORSC7 BLOC-1-RELATED COMPLEX SUBUNIT 7 intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991 HUMAN|HGNC=28356|UniProtKB=Q8TBP0 Q8TBP0 TBC1D16 PTHR22957:SF547 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN TBC1 DOMAIN FAMILY MEMBER 16 enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047 membrane-bounded organelle#GO:0043227;early endosome#GO:0005769;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular vesicle#GO:0097708;vesicle#GO:0031982 GTPase-activating protein#PC00257;protein-binding activity modulator#PC00095;G-protein modulator#PC00022 HUMAN|HGNC=30702|UniProtKB=Q9NP50 Q9NP50 SINHCAF PTHR13422:SF18 SIN3-HDAC COMPLEX-ASSOCIATED FACTOR SIN3-HDAC COMPLEX-ASSOCIATED FACTOR regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of locomotion#GO:0040012;biological regulation#GO:0065007;negative regulation of cell motility#GO:2000146;negative regulation of locomotion#GO:0040013;regulation of cellular process#GO:0050794;regulation of cell migration#GO:0030334;negative regulation of cellular process#GO:0048523;negative regulation of cell migration#GO:0030336;regulation of cell motility#GO:2000145 chromosome#GO:0005694;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;Sin3-type complex#GO:0070822;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;chromatin#GO:0000785;nucleus#GO:0005634;histone deacetylase complex#GO:0000118;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;protein-containing complex#GO:0032991;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228 HUMAN|HGNC=14293|UniProtKB=Q9BXF9 Q9BXF9 TEKT3 PTHR19960:SF24 TEKTIN TEKTIN-3 organelle assembly#GO:0070925;cilium or flagellum-dependent cell motility#GO:0001539;cilium movement#GO:0003341;cilium-dependent cell motility#GO:0060285;cilium organization#GO:0044782;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cell projection organization#GO:0030030;microtubule-based movement#GO:0007018;cell motility#GO:0048870;plasma membrane bounded cell projection assembly#GO:0120031;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cilium movement involved in cell motility#GO:0060294;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036 microtubule cytoskeleton#GO:0015630;plasma membrane bounded cell projection#GO:0120025;intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;sperm flagellum#GO:0036126;cellular anatomical structure#GO:0110165;motile cilium#GO:0031514;organelle#GO:0043226;cilium#GO:0005929;intracellular organelle#GO:0043229;9+2 motile cilium#GO:0097729;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228 non-motor microtubule binding protein#PC00166;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=3317|UniProtKB=Q15723 Q15723 ELF2 PTHR11849:SF10 ETS ETS-RELATED TRANSCRIPTION FACTOR ELF-2 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 winged helix/forkhead transcription factor#PC00246;DNA-binding transcription factor#PC00218 PDGF signaling pathway#P00047>Ets#P01167 HUMAN|HGNC=14994|UniProtKB=Q8NGY7 Q8NGY7 OR10J6P PTHR26453:SF735 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 10J6-RELATED transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;response to chemical#GO:0042221;response to stimulus#GO:0050896;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;detection of chemical stimulus#GO:0009593;system process#GO:0003008;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;nervous system process#GO:0050877;sensory perception#GO:0007600 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=12446|UniProtKB=Q06418 Q06418 TYRO3 PTHR24416:SF279 TYROSINE-PROTEIN KINASE RECEPTOR TYROSINE-PROTEIN KINASE RECEPTOR TYRO3 transmembrane signaling receptor activity#GO:0004888;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;signaling receptor activity#GO:0038023;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity, acting on a protein#GO:0140096 regulation of body fluid levels#GO:0050878;endocytosis#GO:0006897;response to stimulus#GO:0050896;signaling#GO:0023052;regulation of biological process#GO:0050789;regulation of biological quality#GO:0065008;wound healing#GO:0042060;animal gross anatomical part developmental process#GO:0160108;cell adhesion#GO:0007155;nervous system development#GO:0007399;cell-cell adhesion#GO:0098609;response to stress#GO:0006950;cellular process#GO:0009987;signal transduction#GO:0007165;coagulation#GO:0050817;import into cell#GO:0098657;multicellular organism development#GO:0007275;cell surface receptor signaling pathway#GO:0007166;platelet aggregation#GO:0070527;regulation of cellular process#GO:0050794;cell motility#GO:0048870;hemostasis#GO:0007599;cellular response to stimulus#GO:0051716;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;localization#GO:0051179;cell communication#GO:0007154;system development#GO:0048731;cell activation#GO:0001775;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cell migration#GO:0016477;multicellular organismal process#GO:0032501;homotypic cell-cell adhesion#GO:0034109;biological regulation#GO:0065007;response to wounding#GO:0009611;establishment of localization#GO:0051234;platelet activation#GO:0030168;blood coagulation#GO:0007596;phagocytosis#GO:0006909;transport#GO:0006810;developmental process#GO:0032502 plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;signaling receptor complex#GO:0043235;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=15021|UniProtKB=Q7Z3T1 Q7Z3T1 OR2W3 PTHR26453:SF223 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2W3 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 system process#GO:0003008;nervous system process#GO:0050877;sensory perception#GO:0007600;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;response to chemical#GO:0042221;response to stimulus#GO:0050896;detection of chemical stimulus#GO:0009593;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=6812|UniProtKB=O60732 O60732 MAGEC1 PTHR11736:SF17 MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN MELANOMA-ASSOCIATED ANTIGEN C1 negative regulation of metabolic process#GO:0009892;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 scaffold/adaptor protein#PC00226 HUMAN|HGNC=845|UniProtKB=O75947 O75947 ATP5PD PTHR12700:SF17 ATP SYNTHASE SUBUNIT D, MITOCHONDRIAL ATP SYNTHASE PERIPHERAL STALK SUBUNIT D, MITOCHONDRIAL monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261;proton channel activity#GO:0015252;passive transmembrane transporter activity#GO:0022803;catalytic activity#GO:0003824;proton transmembrane transporter activity#GO:0015078;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;ligase activity#GO:0016874;proton-transporting ATP synthase activity, rotational mechanism#GO:0046933;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324 purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;phosphorus metabolic process#GO:0006793;small molecule metabolic process#GO:0044281;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;ribonucleotide metabolic process#GO:0009259;nucleotide biosynthetic process#GO:0009165;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;ATP metabolic process#GO:0046034;ribose phosphate biosynthetic process#GO:0046390;ATP biosynthetic process#GO:0006754;metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing compound biosynthetic process#GO:0034654;nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative biosynthetic process#GO:1901137;ribonucleoside triphosphate biosynthetic process#GO:0009201;purine nucleoside triphosphate metabolic process#GO:0009144;primary metabolic process#GO:0044238;proton motive force-driven ATP synthesis#GO:0015986;nucleoside phosphate metabolic process#GO:0006753;nucleoside triphosphate metabolic process#GO:0009141;purine nucleoside triphosphate biosynthetic process#GO:0009145;organophosphate biosynthetic process#GO:0090407;carbohydrate derivative metabolic process#GO:1901135;purine ribonucleoside triphosphate metabolic process#GO:0009205;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;nucleoside triphosphate biosynthetic process#GO:0009142;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;purine ribonucleoside triphosphate biosynthetic process#GO:0009206;nucleoside phosphate biosynthetic process#GO:1901293 organelle envelope#GO:0031967;membrane protein complex#GO:0098796;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;proton-transporting ATP synthase complex#GO:0045259;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transmembrane transporter complex#GO:1902495;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrial membrane#GO:0031966;respiratory chain complex#GO:0098803;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;cytoplasm#GO:0005737;proton-transporting two-sector ATPase complex#GO:0016469;cation channel complex#GO:0034703;transporter complex#GO:1990351;organelle membrane#GO:0031090 ATP synthase#PC00002;primary active transporter#PC00068;transporter#PC00227 HUMAN|HGNC=15437|UniProtKB=Q9NZP0 Q9NZP0 OR6C3 PTHR26454:SF39 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 6C3 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=43611|UniProtKB=A0A1W2PR95 A0A1W2PR95 IGBP1C PTHR10933:SF15 IMMUNOGLOBULIN-BINDING PROTEIN 1 IMMUNOGLOBULIN-BINDING PROTEIN 1 FAMILY MEMBER C molecular function regulator activity#GO:0098772;protein phosphatase regulator activity#GO:0019888;enzyme regulator activity#GO:0030234;phosphatase regulator activity#GO:0019208 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;TOR signaling#GO:0031929 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 chaperone#PC00072 HUMAN|HGNC=8283|UniProtKB=P47893 P47893 OR3A2 PTHR48001:SF139 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 3A2 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=1541|UniProtKB=P22681 P22681 CBL PTHR23007:SF5 CBL E3 UBIQUITIN-PROTEIN LIGASE CBL receptor tyrosine kinase binding#GO:0030971;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;protein tyrosine kinase binding#GO:1990782;signaling receptor binding#GO:0005102;acyltransferase activity#GO:0016746;transferase activity#GO:0016740;enzyme binding#GO:0019899;ubiquitin protein ligase activity#GO:0061630;protein kinase binding#GO:0019901;binding#GO:0005488;kinase binding#GO:0019900;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;protein binding#GO:0005515 cell communication#GO:0007154;negative regulation of cell communication#GO:0010648;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of cell communication#GO:0010646;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of ERBB signaling pathway#GO:1901184;cellular response to stimulus#GO:0051716;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;negative regulation of response to stimulus#GO:0048585;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;regulation of epidermal growth factor receptor signaling pathway#GO:0042058;signal transduction#GO:0007165;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane raft#GO:0045121;membrane#GO:0016020;cell periphery#GO:0071944;membrane microdomain#GO:0098857 ligase#PC00142 EGF receptor signaling pathway#P00018>c-Cbl#P00544 HUMAN|HGNC=13553|UniProtKB=Q9Y2G3 Q9Y2G3 ATP11B PTHR24092:SF57 PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE PHOSPHOLIPID-TRANSPORTING ATPASE IF intramembrane lipid carrier activity#GO:0140303;lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104;ATPase-coupled intramembrane lipid carrier activity#GO:0140326;transporter activity#GO:0005215;ATP-dependent activity#GO:0140657 regulation of biological quality#GO:0065008;localization#GO:0051179;lipid localization#GO:0010876;lipid translocation#GO:0034204;organophosphate ester transport#GO:0015748;cellular component organization#GO:0016043;regulation of membrane lipid distribution#GO:0097035;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;transport#GO:0006810;phospholipid translocation#GO:0045332;phospholipid transport#GO:0015914;biological regulation#GO:0065007;membrane organization#GO:0061024;lipid transport#GO:0006869;cellular process#GO:0009987;macromolecule localization#GO:0033036 endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;recycling endosome#GO:0055037;cell periphery#GO:0071944;membrane#GO:0016020;cytoplasm#GO:0005737;plasma membrane#GO:0005886;endomembrane system#GO:0012505 primary active transporter#PC00068;transporter#PC00227 HUMAN|Ensembl=ENSG00000251158.2|UniProtKB=A0ABB0MVD7 A0ABB0MVD7 PTHR15566:SF4 POM121-LIKE POM121-LIKE PROTEIN 1-RELATED HUMAN|HGNC=6996|UniProtKB=Q06413 Q06413 MEF2C PTHR11945:SF25 MADS BOX PROTEIN MYOCYTE-SPECIFIC ENHANCER FACTOR 2C DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulator activity#GO:0140110;enzyme binding#GO:0019899;transcription regulatory region nucleic acid binding#GO:0001067;protein binding#GO:0005515;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;histone deacetylase binding#GO:0042826;sequence-specific double-stranded DNA binding#GO:1990837 multicellular organism development#GO:0007275;animal organ development#GO:0048513;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of macromolecule metabolic process#GO:0010604;heart development#GO:0007507;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;animal gross anatomical part developmental process#GO:0160108;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;circulatory system development#GO:0072359;regulation of biological process#GO:0050789;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;multicellular organismal process#GO:0032501;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 MADS box transcription factor#PC00250 Oxidative stress response#P00046>MEF-2#P01128;p38 MAPK pathway#P05918>MEF#P06023;CCKR signaling map#P06959>MEF2C#P07222 HUMAN|HGNC=9788|UniProtKB=P51149 P51149 RAB7A PTHR47981:SF13 RAB FAMILY RAS-RELATED PROTEIN RAB-7A ribonucleoside triphosphate phosphatase activity#GO:0017111;molecular function regulator activity#GO:0098772;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924 organelle assembly#GO:0070925;endosome to lysosome transport#GO:0008333;lysosomal transport#GO:0007041;vacuole organization#GO:0007033;localization#GO:0051179;cellular localization#GO:0051641;cellular component organization#GO:0016043;vesicle fusion#GO:0006906;endocytosis#GO:0006897;vacuolar transport#GO:0007034;transport#GO:0006810;lytic vacuole organization#GO:0080171;phagolysosome assembly#GO:0001845;intracellular transport#GO:0046907;phagocytosis#GO:0006909;vesicle organization#GO:0016050;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;import into cell#GO:0098657;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;lysosome organization#GO:0007040;cellular component biogenesis#GO:0044085;membrane fusion#GO:0061025;organelle organization#GO:0006996;membrane organization#GO:0061024;organelle membrane fusion#GO:0090174;cellular component assembly#GO:0022607;organelle fusion#GO:0048284;vesicle-mediated transport#GO:0016192 intracellular vesicle#GO:0097708;lysosome#GO:0005764;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endocytic vesicle#GO:0030139;late endosome#GO:0005770;endomembrane system#GO:0012505;phagocytic vesicle#GO:0045335;cytoplasm#GO:0005737;vacuole#GO:0005773;lytic vacuole#GO:0000323 small GTPase#PC00208 HUMAN|HGNC=28850|UniProtKB=Q8WUA8 Q8WUA8 TSKU PTHR45617:SF14 LEUCINE RICH REPEAT FAMILY PROTEIN TSUKUSHI scaffold/adaptor protein#PC00226 HUMAN|HGNC=278|UniProtKB=P35368 P35368 ADRA1B PTHR24248:SF17 ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR ALPHA-1B ADRENERGIC RECEPTOR transmembrane signaling receptor activity#GO:0004888;G protein-coupled amine receptor activity#GO:0008227;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089 regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;phospholipase C-activating G protein-coupled receptor signaling pathway#GO:0007200;positive regulation of cytosolic calcium ion concentration#GO:0007204;G protein-coupled receptor signaling pathway#GO:0007186;regulation of biological quality#GO:0065008;adrenergic receptor signaling pathway#GO:0071875;cell communication#GO:0007154;signal transduction#GO:0007165;cellular process#GO:0009987;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021 Alpha adrenergic receptor signaling pathway#P00002>Alpha1A/1B/1C#P00078;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711 HUMAN|HGNC=28160|UniProtKB=Q2QGD7 Q2QGD7 ZXDC PTHR46179:SF5 ZINC FINGER PROTEIN ZINC FINGER PROTEIN ZXDC transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244;DNA-binding transcription factor#PC00218 HUMAN|HGNC=26909|UniProtKB=P83105 P83105 HTRA4 PTHR22939:SF105 SERINE PROTEASE FAMILY S1C HTRA-RELATED SERINE PROTEASE HTRA4 hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;serine-type peptidase activity#GO:0008236;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity#GO:0003824 regulation of cellular process#GO:0050794;positive regulation of programmed cell death#GO:0043068;regulation of biological process#GO:0050789;cell death#GO:0008219;regulation of programmed cell death#GO:0043067;programmed cell death#GO:0012501;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;proteolysis#GO:0006508;biological regulation#GO:0065007;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;positive regulation of apoptotic process#GO:0043065;regulation of apoptotic process#GO:0042981;metabolic process#GO:0008152 protease#PC00190;serine protease#PC00203 HUMAN|HGNC=28319|UniProtKB=Q96S96 Q96S96 PEBP4 PTHR11362:SF82 PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4 protease inhibitor#PC00191 FGF signaling pathway#P00021>RKIP#P00630;EGF receptor signaling pathway#P00018>RKIP#P00548 HUMAN|HGNC=3771|UniProtKB=P31513 P31513 FMO3 PTHR23023:SF44 DIMETHYLANILINE MONOOXYGENASE FLAVIN-CONTAINING MONOOXYGENASE 3 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;monooxygenase activity#GO:0004497;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen#GO:0016709;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 biosynthetic process#GO:0009058;sulfur compound metabolic process#GO:0006790;metabolic process#GO:0008152;cellular process#GO:0009987 oxygenase#PC00177;oxidoreductase#PC00176 Nicotine degradation#P05914>FMO3#P05979 HUMAN|HGNC=14129|UniProtKB=Q96KQ7 Q96KQ7 EHMT2 PTHR46307:SF1 G9A, ISOFORM B HISTONE-LYSINE N-METHYLTRANSFERASE EHMT2 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=13817|UniProtKB=Q9NS84 Q9NS84 CHST7 PTHR10704:SF5 CARBOHYDRATE SULFOTRANSFERASE CARBOHYDRATE SULFOTRANSFERASE 7 transferase activity, transferring sulphur-containing groups#GO:0016782;sulfotransferase activity#GO:0008146;transferase activity#GO:0016740;catalytic activity#GO:0003824 protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;amino sugar metabolic process#GO:0006040;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;proteoglycan metabolic process#GO:0006029;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;carbohydrate derivative metabolic process#GO:1901135;chondroitin sulfate proteoglycan metabolic process#GO:0050654;protein O-linked glycosylation#GO:0006493;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;glycoprotein biosynthetic process#GO:0009101;sulfur compound metabolic process#GO:0006790;proteoglycan biosynthetic process#GO:0030166;biosynthetic process#GO:0009058;chondroitin sulfate proteoglycan biosynthetic process#GO:0050650 transferase#PC00220;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=30385|UniProtKB=Q969E2 Q969E2 SCAMP4 PTHR10687:SF11 SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN SCAMP SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN 4 localization#GO:0051179;establishment of localization#GO:0051234;secretion#GO:0046903;exocytosis#GO:0006887;secretion by cell#GO:0032940;transport#GO:0006810;vesicle-mediated transport#GO:0016192;export from cell#GO:0140352;cellular process#GO:0009987 intracellular organelle#GO:0043229;endosome membrane#GO:0010008;endosome#GO:0005768;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;recycling endosome#GO:0055037;organelle membrane#GO:0031090;recycling endosome membrane#GO:0055038;bounding membrane of organelle#GO:0098588;vesicle membrane#GO:0012506;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;trans-Golgi network membrane#GO:0032588;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802 transfer/carrier protein#PC00219 HUMAN|HGNC=19421|UniProtKB=Q8WYH8 Q8WYH8 ING5 PTHR10333:SF41 INHIBITOR OF GROWTH PROTEIN INHIBITOR OF GROWTH PROTEIN 5 chromatin binding#GO:0003682;histone reader activity#GO:0140566;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;histone H3 reader activity#GO:0140006;chromatin-protein adaptor activity#GO:0140463 regulation of apoptotic process#GO:0042981;cellular component organization or biogenesis#GO:0071840;positive regulation of apoptotic process#GO:0043065;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;cellular component organization#GO:0016043;regulation of programmed cell death#GO:0043067;regulation of biological process#GO:0050789;positive regulation of programmed cell death#GO:0043068;regulation of response to stimulus#GO:0048583;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of response to stimulus#GO:0048584;chromatin organization#GO:0006325;regulation of RNA biosynthetic process#GO:2001141;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of apoptotic signaling pathway#GO:2001233;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;positive regulation of signal transduction#GO:0009967;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of cell communication#GO:0010646;positive regulation of apoptotic signaling pathway#GO:2001235 chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;protein acetyltransferase complex#GO:0031248;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;acetyltransferase complex#GO:1902493;chromatin#GO:0000785;nucleus#GO:0005634;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;histone acetyltransferase complex#GO:0000123;membraneless organelle#GO:0043228 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=18181|UniProtKB=Q92529 Q92529 SHC3 PTHR10337:SF4 SHC TRANSFORMING PROTEIN SHC-TRANSFORMING PROTEIN 3 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 chemical synaptic transmission#GO:0007268;positive regulation of cell population proliferation#GO:0008284;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;response to stimulus#GO:0050896;signaling#GO:0023052;trans-synaptic signaling#GO:0099537;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;synaptic signaling#GO:0099536;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165;synaptic transmission, glutamatergic#GO:0035249;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;cell surface receptor signaling pathway#GO:0007166 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974 scaffold/adaptor protein#PC00226 PDGF signaling pathway#P00047>Shc#P01175;FGF signaling pathway#P00021>Shc#P00639;EGF receptor signaling pathway#P00018>Shc#P00554 HUMAN|HGNC=16075|UniProtKB=Q9H082 Q9H082 RAB33B PTHR47978:SF26 FAMILY NOT NAMED RAS-RELATED PROTEIN RAB-33B nucleoside phosphate binding#GO:1901265;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;guanyl nucleotide binding#GO:0019001;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;ion binding#GO:0043167;GTPase activity#GO:0003924;anion binding#GO:0043168;small molecule binding#GO:0036094;hydrolase activity#GO:0016787;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111 cellular component assembly#GO:0022607;biological regulation#GO:0065007;macroautophagy#GO:0016236;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;autophagy#GO:0006914;cellular process#GO:0009987;autophagosome organization#GO:1905037;cellular component organization or biogenesis#GO:0071840;regulation of transport#GO:0051049;regulation of localization#GO:0032879;autophagosome assembly#GO:0000045;metabolic process#GO:0008152;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;regulation of secretion#GO:0051046;vacuole organization#GO:0007033;process utilizing autophagic mechanism#GO:0061919;regulation of secretion by cell#GO:1903530;regulation of exocytosis#GO:0017157;organelle assembly#GO:0070925 intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;endosome#GO:0005768;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular vesicle#GO:0097708;vesicle#GO:0031982 small GTPase#PC00208 HUMAN|HGNC=18618|UniProtKB=Q5S007 Q5S007 LRRK2 PTHR45752:SF7 LEUCINE-RICH REPEAT-CONTAINING LEUCINE-RICH REPEAT SERINE_THREONINE-PROTEIN KINASE 2 protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;MAP kinase kinase kinase activity#GO:0004709;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740 positive regulation of metabolic process#GO:0009893;regulation of signaling#GO:0023051;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111;regulation of autophagy#GO:0010506;cellular component organization#GO:0016043;Golgi organization#GO:0007030;regulation of biological process#GO:0050789;endoplasmic reticulum organization#GO:0007029;cellular component organization or biogenesis#GO:0071840;positive regulation of catabolic process#GO:0009896;regulation of transport#GO:0051049;regulation of localization#GO:0032879;regulation of catabolic process#GO:0009894;regulation of cell projection organization#GO:0031344;regulation of endocytosis#GO:0030100;regulation of G protein-coupled receptor signaling pathway#GO:0008277;regulation of response to stimulus#GO:0048583;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;endomembrane system organization#GO:0010256;organelle organization#GO:0006996;positive regulation of autophagy#GO:0010508;regulation of canonical Wnt signaling pathway#GO:0060828;regulation of metabolic process#GO:0019222;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987 neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cell projection#GO:0042995;somatodendritic compartment#GO:0036477;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165;dendritic tree#GO:0097447;dendrite#GO:0030425 scaffold/adaptor protein#PC00226 HUMAN|HGNC=24808|UniProtKB=O14545 O14545 TRAFD1 PTHR16295:SF19 TRAF-TYPE ZINC FINGER PROTEIN-RELATED TRAF-TYPE ZINC FINGER DOMAIN-CONTAINING PROTEIN 1 regulation of response to stimulus#GO:0048583;regulation of response to stress#GO:0080134;regulation of innate immune response#GO:0045088;biological regulation#GO:0065007;negative regulation of immune system process#GO:0002683;negative regulation of response to external stimulus#GO:0032102;negative regulation of innate immune response#GO:0045824;regulation of response to external stimulus#GO:0032101;negative regulation of response to stimulus#GO:0048585;negative regulation of immune response#GO:0050777;regulation of immune response#GO:0050776;regulation of defense response#GO:0031347;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of response to biotic stimulus#GO:0002831;regulation of immune system process#GO:0002682;negative regulation of defense response#GO:0031348 mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=14033|UniProtKB=Q96DV4 Q96DV4 MRPL38 PTHR11362:SF133 PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN LARGE RIBOSOMAL SUBUNIT PROTEIN ML38 mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;large ribosomal subunit#GO:0015934;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;organellar ribosome#GO:0000313;mitochondrial ribosome#GO:0005761;membrane-bounded organelle#GO:0043227;ribosome#GO:0005840;mitochondrion#GO:0005739;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrial large ribosomal subunit#GO:0005762;membraneless organelle#GO:0043228;membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798 protease inhibitor#PC00191 HUMAN|HGNC=37172|UniProtKB=A6NEV1 A6NEV1 PRR23A PTHR31813:SF4 PROLINE-RICH PROTEIN 23B PROLINE-RICH PROTEIN 23A HUMAN|HGNC=15183|UniProtKB=Q8NH73 Q8NH73 OR4S2 PTHR48002:SF131 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 4S2 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=10939|UniProtKB=P43005 P43005 SLC1A1 PTHR11958:SF109 SODIUM/DICARBOXYLATE SYMPORTER-RELATED EXCITATORY AMINO ACID TRANSPORTER 3 neutral L-amino acid transmembrane transporter activity#GO:0015175;transmembrane transporter activity#GO:0022857;solute:monoatomic cation symporter activity#GO:0015294;dicarboxylic acid transmembrane transporter activity#GO:0005310;L-glutamate transmembrane transporter activity#GO:0005313;sodium ion transmembrane transporter activity#GO:0015081;active transmembrane transporter activity#GO:0022804;acidic amino acid transmembrane transporter activity#GO:0015172;L-amino acid transmembrane transporter activity#GO:0015179;carboxylic acid transmembrane transporter activity#GO:0046943;solute:sodium symporter activity#GO:0015370;amino acid:sodium symporter activity#GO:0005283;amino acid transmembrane transporter activity#GO:0015171;secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;symporter activity#GO:0015293;sodium:dicarboxylate symporter activity#GO:0017153;monoatomic cation transmembrane transporter activity#GO:0008324 transmembrane transport#GO:0055085;amino acid transmembrane transport#GO:0003333;localization#GO:0051179;L-glutamate import#GO:0051938;carboxylic acid transmembrane transport#GO:1905039;L-alpha-amino acid transmembrane transport#GO:1902475;establishment of localization#GO:0051234;carboxylic acid transport#GO:0046942;transport#GO:0006810;acidic amino acid transport#GO:0015800;amino acid transport#GO:0006865;organic acid transport#GO:0015849;dicarboxylic acid transport#GO:0006835;L-glutamate transmembrane transport#GO:0015813;cellular process#GO:0009987;nitrogen compound transport#GO:0071705;L-amino acid transport#GO:0015807 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 primary active transporter#PC00068 Metabotropic glutamate receptor group III pathway#P00039>EAAT#P01036;Ionotropic glutamate receptor pathway#P00037>EAAT#P01011 HUMAN|HGNC=14682|UniProtKB=Q5VX52 Q5VX52 SPATA1 PTHR14421:SF3 SPERMATOGENESIS-ASSOCIATED PROTEIN 1 SPERMATOGENESIS-ASSOCIATED PROTEIN 1 HUMAN|HGNC=23481|UniProtKB=Q68J44 Q68J44 DUSP29 PTHR45682:SF6 AGAP008228-PA DUAL SPECIFICITY PHOSPHATASE 29 protein tyrosine/serine/threonine phosphatase activity#GO:0008138;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721 negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of MAPK cascade#GO:0043408;negative regulation of response to stimulus#GO:0048585;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;negative regulation of MAPK cascade#GO:0043409;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195 Oxidative stress response#P00046>MKP5#P01131 HUMAN|HGNC=11633|UniProtKB=P15923 P15923 TCF3 PTHR11793:SF14 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR TRANSCRIPTION FACTOR E2-ALPHA sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;somatic diversification of immune receptors#GO:0002200;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;developmental process#GO:0032502;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;macromolecule biosynthetic process#GO:0009059;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;biosynthetic process#GO:0009058;regulation of RNA biosynthetic process#GO:2001141;nucleobase-containing compound metabolic process#GO:0006139;somatic cell DNA recombination#GO:0016444;immune system process#GO:0002376;animal gross anatomical part developmental process#GO:0160108;somatic diversification of immune receptors via germline recombination within a single locus#GO:0002562;immune system development#GO:0002520;regulation of biological process#GO:0050789;V(D)J recombination#GO:0033151;regulation of transcription by RNA polymerase II#GO:0006357;production of molecular mediator of immune response#GO:0002440;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;DNA recombination#GO:0006310;multicellular organism development#GO:0007275;cellular process#GO:0009987;somatic recombination of immunoglobulin gene segments#GO:0016447;gene expression#GO:0010467 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694;chromatin#GO:0000785;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;transcription regulator complex#GO:0005667;intracellular organelle#GO:0043229 basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=25323|UniProtKB=A4QPB2 A4QPB2 LRP5L PTHR46513:SF43 VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5-LIKE PROTEIN transmembrane signal receptor#PC00197 HUMAN|HGNC=1407|UniProtKB=O60359 O60359 CACNG3 PTHR12107:SF5 VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA SUBUNIT VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-3 SUBUNIT calcium channel activity#GO:0005262;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;molecular function regulator activity#GO:0098772;monoatomic cation channel activity#GO:0005261;transporter regulator activity#GO:0141108;channel regulator activity#GO:0016247;channel activity#GO:0015267;voltage-gated calcium channel activity#GO:0005245;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832 positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regulation of trans-synaptic signaling#GO:0099177;regulation of postsynaptic membrane neurotransmitter receptor levels#GO:0099072;transmission of nerve impulse#GO:0019226;system process#GO:0003008;regulation of biological process#GO:0050789;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;localization within membrane#GO:0051668;nervous system process#GO:0050877;regulation of signaling#GO:0023051;positive regulation of synaptic transmission#GO:0050806;regulation of biological quality#GO:0065008;localization#GO:0051179;cell communication#GO:0007154;regulation of synaptic transmission, glutamatergic#GO:0051966;positive regulation of signaling#GO:0023056;cellular localization#GO:0051641 membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane region#GO:0098590;postsynaptic specialization#GO:0099572;neuron to neuron synapse#GO:0098984;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;signaling receptor complex#GO:0043235;synaptic membrane#GO:0097060;cell junction#GO:0030054;transporter complex#GO:1990351;membrane protein complex#GO:0098796;postsynapse#GO:0098794;plasma membrane protein complex#GO:0098797;organelle#GO:0043226;asymmetric synapse#GO:0032279;synapse#GO:0045202;cellular anatomical structure#GO:0110165;postsynaptic specialization membrane#GO:0099634;postsynaptic membrane#GO:0045211;postsynaptic density#GO:0014069;transmembrane transporter complex#GO:1902495;postsynaptic density membrane#GO:0098839 ion channel#PC00133;transporter#PC00227;voltage-gated ion channel#PC00241 HUMAN|HGNC=588|UniProtKB=O94817 O94817 ATG12 PTHR13385:SF5 AUTOPHAGY PROTEIN 12 UBIQUITIN-LIKE PROTEIN ATG12 ubiquitin-like protein ligase activity#GO:0061659;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746 cellular component assembly#GO:0022607;autophagosome organization#GO:1905037;cellular process#GO:0009987;autophagy#GO:0006914;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;autophagosome assembly#GO:0000045;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;glucan catabolic process#GO:0009251;polysaccharide metabolic process#GO:0005976;polysaccharide catabolic process#GO:0000272;cellular component organization#GO:0016043;glucan metabolic process#GO:0044042;process utilizing autophagic mechanism#GO:0061919;cellular component disassembly#GO:0022411;carbohydrate catabolic process#GO:0016052;macroautophagy#GO:0016236;glycogen catabolic process#GO:0005980;energy derivation by oxidation of organic compounds#GO:0015980;macromolecule metabolic process#GO:0043170;generation of precursor metabolites and energy#GO:0006091;autophagosome maturation#GO:0097352;autophagy of mitochondrion#GO:0000422;piecemeal microautophagy of the nucleus#GO:0034727;carbohydrate metabolic process#GO:0005975;protein-containing complex disassembly#GO:0032984;catabolic process#GO:0009056;primary metabolic process#GO:0044238;glycogen metabolic process#GO:0005977;vacuole organization#GO:0007033;organelle assembly#GO:0070925;energy reserve metabolic process#GO:0006112 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;autophagosome#GO:0005776;intracellular anatomical structure#GO:0005622;autophagosome membrane#GO:0000421;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;cytoplasm#GO:0005737;vacuole#GO:0005773;protein-containing complex#GO:0032991;transferase complex#GO:1990234;phagophore assembly site#GO:0000407;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;vacuolar membrane#GO:0005774 HUMAN|HGNC=2559|UniProtKB=P78310 P78310 CXADR PTHR44468:SF3 COXSACKIEVIRUS AND ADENOVIRUS RECEPTOR-RELATED COXSACKIEVIRUS AND ADENOVIRUS RECEPTOR protein binding#GO:0005515;binding#GO:0005488;cell adhesion molecule binding#GO:0050839 homotypic cell-cell adhesion#GO:0034109;cellular process#GO:0009987;cell adhesion#GO:0007155;cell-cell adhesion#GO:0098609 apical junction complex#GO:0043296;cell-cell contact zone#GO:0044291;tight junction#GO:0070160;cell junction#GO:0030054;cell periphery#GO:0071944;basal plasma membrane#GO:0009925;cell-cell junction#GO:0005911;membrane#GO:0016020;basolateral plasma membrane#GO:0016323;plasma membrane#GO:0005886;plasma membrane region#GO:0098590;bicellular tight junction#GO:0005923;anchoring junction#GO:0070161;intercalated disc#GO:0014704;basal part of cell#GO:0045178;cellular anatomical structure#GO:0110165 HUMAN|HGNC=32348|UniProtKB=A2A3L6 A2A3L6 TTC24 PTHR47050:SF2 TETRATRICOPEPTIDE REPEAT PROTEIN 24 TETRATRICOPEPTIDE REPEAT PROTEIN 24 HUMAN|HGNC=2602|UniProtKB=Q07973 Q07973 CYP24A1 PTHR24291:SF5 CYTOCHROME P450 FAMILY 4 1,25-DIHYDROXYVITAMIN D(3) 24-HYDROXYLASE, MITOCHONDRIAL oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;monooxygenase activity#GO:0004497;steroid hydroxylase activity#GO:0008395;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 lipid catabolic process#GO:0016042;cellular process#GO:0009987;response to nutrient levels#GO:0031667;steroid metabolic process#GO:0008202;response to chemical#GO:0042221;response to lipid#GO:0033993;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;vitamin D metabolic process#GO:0042359;primary metabolic process#GO:0044238;small molecule catabolic process#GO:0044282;response to stimulus#GO:0050896;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;response to oxygen-containing compound#GO:1901700;steroid catabolic process#GO:0006706 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262;oxygenase#PC00177 Vitamin D metabolism and pathway#P04396>24-Hydroxylase#P04608;Vitamin D metabolism and pathway#P04396>24-Hydroxylase#G04688 HUMAN|HGNC=28188|UniProtKB=Q9BRQ4 Q9BRQ4 CFAP300 PTHR31078:SF1 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 300 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 300 structural protein#PC00211 HUMAN|HGNC=8533|UniProtKB=P51575 P51575 P2RX1 PTHR10125:SF9 P2X PURINOCEPTOR P2X PURINOCEPTOR 1 extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;ligand-gated monoatomic cation channel activity#GO:0099094;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;gated channel activity#GO:0022836;ligand-gated monoatomic ion channel activity#GO:0015276 monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;calcium ion transmembrane transport#GO:0070588;cellular process#GO:0009987;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;localization#GO:0051179;calcium ion transport#GO:0006816;monoatomic ion transport#GO:0006811;transport#GO:0006810 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 ligand-gated ion channel#PC00141 HUMAN|HGNC=23436|UniProtKB=B3EWG3 B3EWG3 FAM25A PTHR34994:SF1 PROTEIN FAM25A-RELATED PROTEIN FAM25A-RELATED HUMAN|HGNC=13111|UniProtKB=Q02386 Q02386 ZNF45 PTHR24377:SF1055 IP01015P-RELATED ZINC FINGER PROTEIN 45 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=33829|UniProtKB=Q6ZR37 Q6ZR37 PLEKHG7 PTHR13217:SF6 PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7 PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7 GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 HUMAN|HGNC=26969|UniProtKB=Q7Z3D4 Q7Z3D4 LYSMD3 PTHR20932:SF5 LYSM AND PUTATIVE PEPTIDOGLYCAN-BINDING DOMAIN-CONTAINING PROTEIN AND PUTATIVE PEPTIDOGLYCAN-BINDING DOMAIN-CONTAINING PROTEIN 3-RELATED Golgi organization#GO:0007030;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;endomembrane system organization#GO:0010256;cellular component organization or biogenesis#GO:0071840 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=10368|UniProtKB=P62917 P62917 RPL8 PTHR13691:SF16 RIBOSOMAL PROTEIN L2 LARGE RIBOSOMAL SUBUNIT PROTEIN UL2 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;cytoplasmic translation#GO:0002181;translation#GO:0006412;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;ribosome#GO:0005840;cytosol#GO:0005829;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625 ribosomal protein#PC00202 HUMAN|HGNC=1426|UniProtKB=Q9ULU8 Q9ULU8 CADPS PTHR12166:SF6 CALCIUM-DEPENDENT SECRETION ACTIVATOR CALCIUM-DEPENDENT SECRETION ACTIVATOR 1 regulation of cellular process#GO:0050794;export from cell#GO:0140352;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;secretion#GO:0046903;localization#GO:0051179;regulation of secretion#GO:0051046;regulation of secretion by cell#GO:1903530;regulation of exocytosis#GO:0017157;secretion by cell#GO:0032940;positive regulation of secretion#GO:0051047;vesicle-mediated transport#GO:0016192;biological regulation#GO:0065007;cellular process#GO:0009987;positive regulation of transport#GO:0051050;positive regulation of secretion by cell#GO:1903532;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;establishment of localization#GO:0051234;exocytosis#GO:0006887;regulation of localization#GO:0032879;regulation of transport#GO:0051049;transport#GO:0006810 glutamatergic synapse#GO:0098978;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell junction#GO:0030054 membrane traffic protein#PC00150;membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=45034|UniProtKB=A0A494C191 A0A494C191 SPDYE9 PTHR31156:SF15 WBSCR19-LIKE PROTEIN SPEEDY PROTEIN E10-RELATED HUMAN|HGNC=25137|UniProtKB=A0AVI4 A0AVI4 TMEM129 PTHR31322:SF2 E3 UBIQUITIN-PROTEIN LIGASE TM129 E3 UBIQUITIN-PROTEIN LIGASE TM129 aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=5006|UniProtKB=P04035 P04035 HMGCR PTHR10572:SF24 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824 sterol metabolic process#GO:0016125;isoprenoid metabolic process#GO:0006720;steroid biosynthetic process#GO:0006694;lipid metabolic process#GO:0006629;isoprenoid biosynthetic process#GO:0008299;metabolic process#GO:0008152;biosynthetic process#GO:0009058;steroid metabolic process#GO:0008202;sterol biosynthetic process#GO:0016126;lipid biosynthetic process#GO:0008610;cellular process#GO:0009987;primary metabolic process#GO:0044238 cytoplasm#GO:0005737;endomembrane system#GO:0012505;peroxisomal membrane#GO:0005778;microbody#GO:0042579;membrane#GO:0016020;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;peroxisome#GO:0005777;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229 reductase#PC00198 Cholesterol biosynthesis#P00014>Hydroxymethyl glutaryl CoA reductase#P00491 HUMAN|HGNC=18596|UniProtKB=Q14390 Q14390 GGTLC2 PTHR45027:SF5 PUTATIVE GLUTATHIONE HYDROLASE LIGHT CHAIN GLUTATHIONE HYDROLASE LIGHT CHAIN 2-RELATED hydrolase#PC00121 HUMAN|HGNC=15855|UniProtKB=Q9NPY3 Q9NPY3 CD93 PTHR24034:SF217 EGF-LIKE DOMAIN-CONTAINING PROTEIN COMPLEMENT COMPONENT C1Q RECEPTOR extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HUMAN|HGNC=22788|UniProtKB=A0PJY2 A0PJY2 FEZF1 PTHR24390:SF70 ZINC FINGER PROTEIN FEZ FAMILY ZINC FINGER PROTEIN 1 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218 HUMAN|HGNC=7141|UniProtKB=P12872 P12872 MLN PTHR14156:SF0 MOTILIN PROMOTILIN signaling receptor binding#GO:0005102;binding#GO:0005488;G protein-coupled receptor binding#GO:0001664;protein binding#GO:0005515 HUMAN|HGNC=31923|UniProtKB=Q86VQ0 Q86VQ0 LCA5 PTHR16650:SF10 C21ORF13-RELATED LEBERCILIN organelle organization#GO:0006996;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;cytoskeleton-dependent intracellular transport#GO:0030705;plasma membrane bounded cell projection organization#GO:0120036;intracellular transport#GO:0046907;transport#GO:0006810;cellular component organization or biogenesis#GO:0071840;transport along microtubule#GO:0010970;establishment of localization#GO:0051234;microtubule-based process#GO:0007017;cellular component organization#GO:0016043;cell projection organization#GO:0030030;microtubule-based movement#GO:0007018;intraciliary transport#GO:0042073;microtubule-based transport#GO:0099111;localization#GO:0051179;cellular localization#GO:0051641;cilium organization#GO:0044782 cilium#GO:0005929;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;axoneme#GO:0005930;membraneless organelle#GO:0043228;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;ciliary plasm#GO:0097014;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=12209|UniProtKB=A0A5B6 A0A5B6 TRBV28 PTHR23268:SF121 T-CELL RECEPTOR BETA CHAIN T CELL RECEPTOR BETA VARIABLE 28 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=31704|UniProtKB=Q6HA08 Q6HA08 ASTL PTHR10127:SF855 DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING ASTACIN-LIKE METALLOENDOPEPTIDASE peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 cell activation#GO:0001775;sexual reproduction#GO:0019953;cellular process#GO:0009987;regulation of biological process#GO:0050789;single fertilization#GO:0007338;negative regulation of biological process#GO:0048519;fertilization#GO:0009566;reproductive process#GO:0022414;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regulation of reproductive process#GO:2000241 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease#PC00190;metalloprotease#PC00153 HUMAN|HGNC=7656|UniProtKB=P13591 P13591 NCAM1 PTHR12231:SF239 CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN NEURAL CELL ADHESION MOLECULE 1 binding#GO:0005488;cell adhesion molecule binding#GO:0050839;cell adhesion mediator activity#GO:0098631;protein binding#GO:0005515 cell-cell adhesion#GO:0098609;neuron projection development#GO:0031175;cellular process#GO:0009987;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cell projection morphogenesis#GO:0048858;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell development#GO:0048468;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;cell adhesion#GO:0007155;axonogenesis#GO:0007409;neuron development#GO:0048666;axon development#GO:0061564;axon guidance#GO:0007411;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;neuron projection guidance#GO:0097485;anatomical structure development#GO:0048856;system development#GO:0048731 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;cell junction#GO:0030054 immunoglobulin superfamily cell adhesion molecule#PC00125;cell adhesion molecule#PC00069 HUMAN|HGNC=4136|UniProtKB=Q14353 Q14353 GAMT PTHR32379:SF2 GUANIDINOACETATE N-METHYLTRANSFERASE GUANIDINOACETATE N-METHYLTRANSFERASE transferase activity, transferring one-carbon groups#GO:0016741;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;catalytic activity#GO:0003824;transferase activity#GO:0016740 small molecule metabolic process#GO:0044281;biosynthetic process#GO:0009058;modified amino acid metabolic process#GO:0006575;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid biosynthetic process#GO:0046394;cellular process#GO:0009987;monocarboxylic acid biosynthetic process#GO:0072330;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;small molecule biosynthetic process#GO:0044283 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 methyltransferase#PC00155;transferase#PC00220 HUMAN|HGNC=20507|UniProtKB=Q7L7L0 Q7L7L0 H2AC25 PTHR23430:SF220 HISTONE H2A HISTONE H2A TYPE 3 structural molecule activity#GO:0005198 cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;negative regulation of gene expression, epigenetic#GO:0045814;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;cellular component assembly#GO:0022607;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;chromatin organization#GO:0006325;heterochromatin organization#GO:0070828;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of macromolecule biosynthetic process#GO:0010556;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;heterochromatin formation#GO:0031507 membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;protein-DNA complex#GO:0032993;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleosome#GO:0000786;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;chromatin#GO:0000785;nucleus#GO:0005634 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=17609|UniProtKB=Q8WWW0 Q8WWW0 RASSF5 PTHR22738:SF9 RASSF RAS ASSOCIATION DOMAIN-CONTAINING PROTEIN 5 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;cell communication#GO:0007154 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 scaffold/adaptor protein#PC00226 HUMAN|HGNC=10736|UniProtKB=Q13591 Q13591 SEMA5A PTHR11036:SF78 SEMAPHORIN SEMAPHORIN-5A binding#GO:0005488;signaling receptor binding#GO:0005102;molecular function activator activity#GO:0140677;protein binding#GO:0005515;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772 generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;axonogenesis#GO:0007409;neuron development#GO:0048666;developmental growth involved in morphogenesis#GO:0060560;neuron projection extension#GO:1990138;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;positive regulation of cell motility#GO:2000147;cell development#GO:0048468;signaling#GO:0023052;cell morphogenesis#GO:0000902;response to stimulus#GO:0050896;cell differentiation#GO:0030154;cell projection organization#GO:0030030;growth#GO:0040007;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell surface receptor signaling pathway#GO:0007166;neuron differentiation#GO:0030182;cell projection morphogenesis#GO:0048858;cell growth#GO:0016049;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;neuron projection development#GO:0031175;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;axon extension#GO:0048675;system development#GO:0048731;anatomical structure development#GO:0048856;cell communication#GO:0007154;regulation of cell motility#GO:2000145;cellular response to stimulus#GO:0051716;developmental cell growth#GO:0048588;regulation of cellular process#GO:0050794;neuron projection morphogenesis#GO:0048812;regulation of cell migration#GO:0030334;developmental process#GO:0032502;neurogenesis#GO:0022008;neuron projection guidance#GO:0097485;positive regulation of locomotion#GO:0040017;developmental growth#GO:0048589;cellular developmental process#GO:0048869;positive regulation of cell migration#GO:0030335;positive regulation of cellular process#GO:0048522;axon guidance#GO:0007411;axon development#GO:0061564;plasma membrane bounded cell projection organization#GO:0120036;regulation of locomotion#GO:0040012;biological regulation#GO:0065007;multicellular organismal process#GO:0032501 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 membrane-bound signaling molecule#PC00152 HUMAN|HGNC=10257|UniProtKB=Q01974 Q01974 ROR2 PTHR24416:SF132 TYROSINE-PROTEIN KINASE RECEPTOR TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR2 protein binding#GO:0005515;Wnt-protein binding#GO:0017147;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;transferase activity#GO:0016740;kinase activity#GO:0016301;transmembrane receptor protein tyrosine kinase activity#GO:0004714;molecular transducer activity#GO:0060089;catalytic activity, acting on a protein#GO:0140096;transmembrane receptor protein kinase activity#GO:0019199;protein tyrosine kinase activity#GO:0004713;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772 biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cell surface receptor signaling pathway#GO:0007166 signaling receptor complex#GO:0043235;axon#GO:0030424;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;neuron projection#GO:0043005;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=23489|UniProtKB=Q96DC8 Q96DC8 ECHDC3 PTHR43602:SF1 FAMILY NOT NAMED ENOYL-COA HYDRATASE DOMAIN-CONTAINING PROTEIN 3, MITOCHONDRIAL catalytic activity#GO:0003824;hydro-lyase activity#GO:0016836;lyase activity#GO:0016829;carbon-oxygen lyase activity#GO:0016835 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=13061|UniProtKB=Q14587 Q14587 ZNF268 PTHR24376:SF233 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 268-RELATED negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HUMAN|HGNC=29942|UniProtKB=Q9H1Z9 Q9H1Z9 TSPAN10 PTHR19282:SF550 TETRASPANIN TETRASPANIN-10 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HUMAN|HGNC=291|UniProtKB=P30566 P30566 ADSL PTHR43172:SF1 ADENYLOSUCCINATE LYASE ADENYLOSUCCINATE LYASE lyase activity#GO:0016829;catalytic activity#GO:0003824 nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;ribose phosphate biosynthetic process#GO:0046390;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;carbohydrate derivative metabolic process#GO:1901135;carbohydrate derivative biosynthetic process#GO:1901137;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing small molecule metabolic process#GO:0055086;purine nucleoside monophosphate metabolic process#GO:0009126;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;nucleoside monophosphate metabolic process#GO:0009123;purine ribonucleoside monophosphate metabolic process#GO:0009167;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;organophosphate biosynthetic process#GO:0090407;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide biosynthetic process#GO:0009165;ribonucleotide metabolic process#GO:0009259;nucleoside monophosphate biosynthetic process#GO:0009124;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 lyase#PC00144;metabolite interconversion enzyme#PC00262 De novo purine biosynthesis#P02738>Adenosuccinate lyase#P02901;De novo purine biosynthesis#P02738>5-Phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole lyase#P02892 HUMAN|HGNC=37706|UniProtKB=P0CG00 P0CG00 ZSCAN5DP PTHR23226:SF138 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 5A-RELATED sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=5884|UniProtKB=A0A075B6I4 A0A075B6I4 IGLV10-54 PTHR23267:SF225 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN LAMBDA VARIABLE 10-54 response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 protein-containing complex#GO:0032991 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=27455|UniProtKB=Q8IZ40 Q8IZ40 RCOR2 PTHR16089:SF12 REST COREPRESSOR COREST PROTEIN-RELATED REST COREPRESSOR 2 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;protein-containing complex#GO:0032991;nucleus#GO:0005634;histone deacetylase complex#GO:0000118;membrane-enclosed lumen#GO:0031974;transcription regulator complex#GO:0005667;nuclear protein-containing complex#GO:0140513 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=9299|UniProtKB=P67775 P67775 PPP2CA PTHR45619:SF81 SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED SERINE_THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787 mitotic cell cycle#GO:0000278;cell cycle#GO:0007049;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 protein modifying enzyme#PC00260;protein phosphatase#PC00195 p53 pathway feedback loops 2#P04398>PP2A-C#P04659;Wnt signaling pathway#P00057>PP2A#P01438;FGF signaling pathway#P00021>PP2A#P00629;p53 pathway by glucose deprivation#P04397>PP2A-C#P04643;p53 pathway#P00059>PP2A#P04630;EGF receptor signaling pathway#P00018>PP2A#P00547 HUMAN|HGNC=25526|UniProtKB=Q86YD7 Q86YD7 FAM90A1 PTHR16035:SF18 PROTEIN FAM90A1 PROTEIN FAM90A1 HUMAN|HGNC=14927|UniProtKB=Q9BZW7 Q9BZW7 TSGA10 PTHR23159:SF14 CENTROSOMAL PROTEIN 2 TESTIS-SPECIFIC GENE 10 PROTEIN organelle assembly#GO:0070925;centriole replication#GO:0007099;microtubule cytoskeleton organization#GO:0000226;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;cell cycle#GO:0007049;cell cycle process#GO:0022402;centrosome cycle#GO:0007098;cellular component organization or biogenesis#GO:0071840;centrosome duplication#GO:0051298;microtubule-based process#GO:0007017;microtubule organizing center organization#GO:0031023;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010 membraneless organelle#GO:0043228;centrosome#GO:0005813;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;centriole#GO:0005814;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cilium#GO:0005929;intracellular organelle#GO:0043229;motile cilium#GO:0031514;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=16353|UniProtKB=Q9UNF1 Q9UNF1 MAGED2 PTHR11736:SF11 MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN MELANOMA-ASSOCIATED ANTIGEN D2 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of macromolecule metabolic process#GO:0010605;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 scaffold/adaptor protein#PC00226 HUMAN|HGNC=17981|UniProtKB=O00442 O00442 RTCA PTHR11096:SF0 RNA 3' TERMINAL PHOSPHATE CYCLASE RNA 3'-TERMINAL PHOSPHATE CYCLASE catalytic activity, acting on RNA#GO:0140098;cyclase activity#GO:0009975;ligase activity#GO:0016874;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 RNA metabolism protein#PC00031 HUMAN|HGNC=12428|UniProtKB=Q15672 Q15672 TWIST1 PTHR23349:SF64 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST TWIST-RELATED PROTEIN 1 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=19569|UniProtKB=Q8NG84 Q8NG84 OR2AK2 PTHR26453:SF299 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2AK2 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 system process#GO:0003008;sensory perception#GO:0007600;nervous system process#GO:0050877;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;response to stimulus#GO:0050896;response to chemical#GO:0042221;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;detection of chemical stimulus#GO:0009593;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=4678|UniProtKB=P43080 P43080 GUCA1A PTHR23055:SF13 CALCIUM BINDING PROTEINS GUANYLYL CYCLASE-ACTIVATING PROTEIN 1 cyclase regulator activity#GO:0010851;enzyme activator activity#GO:0008047;molecular function regulator activity#GO:0098772;calcium ion binding#GO:0005509;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;cation binding#GO:0043169;molecular function activator activity#GO:0140677;metal ion binding#GO:0046872;enzyme regulator activity#GO:0030234 system process#GO:0003008;visual perception#GO:0007601;multicellular organismal process#GO:0032501;sensory perception#GO:0007600;nervous system process#GO:0050877;sensory perception of light stimulus#GO:0050953 9+0 non-motile cilium#GO:0097731;photoreceptor cell cilium#GO:0097733;neuron projection#GO:0043005;cellular anatomical structure#GO:0110165;photoreceptor outer segment#GO:0001750;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;photoreceptor inner segment#GO:0001917;cilium#GO:0005929;non-motile cilium#GO:0097730;membrane-bounded organelle#GO:0043227 calmodulin-related#PC00061 HUMAN|HGNC=28960|UniProtKB=Q14667 Q14667 BLTP2 PTHR15678:SF6 ANTIGEN MLAA-22-RELATED BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 2 HUMAN|HGNC=22215|UniProtKB=Q9P2G1 Q9P2G1 ANKIB1 PTHR11685:SF463 RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING ANKYRIN REPEAT AND IBR DOMAIN-CONTAINING PROTEIN 1 protein binding#GO:0005515;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;binding#GO:0005488;ubiquitin-like protein transferase activity#GO:0019787;enzyme binding#GO:0019899;ubiquitin protein ligase activity#GO:0061630;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740 macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;ubiquitin ligase complex#GO:0000151;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;transferase complex#GO:1990234 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=8883|UniProtKB=O94921 O94921 CDK14 PTHR24056:SF154 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE 14 cyclin binding#GO:0030332;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;cyclin-dependent protein serine/threonine kinase activity#GO:0004693;protein serine/threonine kinase activity#GO:0004674;cyclin-dependent protein kinase activity#GO:0097472;binding#GO:0005488;protein kinase activity#GO:0004672;protein binding#GO:0005515;phosphotransferase activity, alcohol group as acceptor#GO:0016773 mitotic cell cycle process#GO:1903047;mitotic cell cycle phase transition#GO:0044772;mitotic cell cycle#GO:0000278;cell cycle phase transition#GO:0044770;G2/M transition of mitotic cell cycle#GO:0000086;cell cycle#GO:0007049;cell cycle G2/M phase transition#GO:0044839;cellular process#GO:0009987;cell cycle process#GO:0022402 cytosol#GO:0005829;nucleus#GO:0005634;protein-containing complex#GO:0032991;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;cytoplasm#GO:0005737;transferase complex#GO:1990234;protein kinase complex#GO:1902911;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=9404|UniProtKB=P41743 P41743 PRKCI PTHR24356:SF214 SERINE/THREONINE-PROTEIN KINASE PROTEIN KINASE C IOTA TYPE protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096 response to hormone#GO:0009725;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;cellular process#GO:0009987;response to chemical#GO:0042221;protein localization to cell periphery#GO:1990778;response to endogenous stimulus#GO:0009719;protein localization to membrane#GO:0072657;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;cellular response to hormone stimulus#GO:0032870;signaling#GO:0023052;establishment or maintenance of cell polarity#GO:0007163;cellular response to chemical stimulus#GO:0070887;response to oxygen-containing compound#GO:1901700;cellular localization#GO:0051641;macromolecule localization#GO:0033036;cellular response to nitrogen compound#GO:1901699;biological regulation#GO:0065007;response to peptide hormone#GO:0043434;cellular response to insulin stimulus#GO:0032869;intracellular protein localization#GO:0008104;protein localization to plasma membrane#GO:0072659;establishment of cell polarity#GO:0030010;response to insulin#GO:0032868;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;cellular response to peptide hormone stimulus#GO:0071375;localization within membrane#GO:0051668;cell communication#GO:0007154;localization#GO:0051179;response to nitrogen compound#GO:1901698;intracellular signal transduction#GO:0035556 non-receptor serine/threonine protein kinase#PC00167 EGF receptor signaling pathway#P00018>PKC#P00565;Histamine H1 receptor mediated signaling pathway#P04385>PKC#P04487;VEGF signaling pathway#P00056>PKC#P01425;Angiogenesis#P00005>PKC#P00219;5HT2 type receptor mediated signaling pathway#P04374>PKC#P04420;Endothelin signaling pathway#P00019>PKC#P00568;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>PKC#P00745;Thyrotropin-releasing hormone receptor signaling pathway#P04394>PKC#P04583;FGF signaling pathway#P00021>PKC#P00648;Alzheimer disease-amyloid secretase pathway#P00003>PKC#P00109;Oxytocin receptor mediated signaling pathway#P04391>PKC#P04533;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>PKC#P01074;Wnt signaling pathway#P00057>Protein Kinase C#P01458 HUMAN|HGNC=10809|UniProtKB=Q13326 Q13326 SGCG PTHR12939:SF4 SARCOGLYCAN GAMMA-SARCOGLYCAN circulatory system development#GO:0072359;heart process#GO:0003015;system development#GO:0048731;muscle tissue development#GO:0060537;anatomical structure development#GO:0048856;circulatory system process#GO:0003013;animal gross anatomical part developmental process#GO:0160108;heart development#GO:0007507;blood circulation#GO:0008015;tissue development#GO:0009888;multicellular organismal process#GO:0032501;heart contraction#GO:0060047;system process#GO:0003008;multicellular organism development#GO:0007275;cardiac muscle tissue development#GO:0048738;animal organ development#GO:0048513;striated muscle tissue development#GO:0014706;developmental process#GO:0032502 sarcolemma#GO:0042383;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane protein complex#GO:0098796;dystrophin-associated glycoprotein complex#GO:0016010;membrane#GO:0016020;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944 cytoskeletal protein#PC00085 HUMAN|HGNC=5244|UniProtKB=P38646 P38646 HSPA9 PTHR19375:SF184 HEAT SHOCK PROTEIN 70KDA STRESS-70 PROTEIN, MITOCHONDRIAL ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817;heat shock protein binding#GO:0031072;hydrolase activity#GO:0016787;protein binding#GO:0005515;ATP hydrolysis activity#GO:0016887;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;ATP-dependent activity#GO:0140657 biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467;cellular component assembly#GO:0022607;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;protein folding#GO:0006457;iron-sulfur cluster assembly#GO:0016226;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;protein refolding#GO:0042026;protein metabolic process#GO:0019538 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739 chaperone#PC00072;Hsp70 family chaperone#PC00027 Parkinson disease#P00049>Hsp70#P01208 HUMAN|HGNC=3087|UniProtKB=Q92997 Q92997 DVL3 PTHR10878:SF6 SEGMENT POLARITY PROTEIN DISHEVELLED SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3 protein binding#GO:0005515;frizzled binding#GO:0005109;G protein-coupled receptor binding#GO:0001664;binding#GO:0005488;signaling receptor binding#GO:0005102 response to stimulus#GO:0050896;Wnt signaling pathway#GO:0016055;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;canonical Wnt signaling pathway#GO:0060070;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 scaffold/adaptor protein#PC00226 Alzheimer disease-presenilin pathway#P00004>Dsh#P00132;Angiogenesis#P00005>Dsh#P00200;Wnt signaling pathway#P00057>Dishevelled#P01447 HUMAN|HGNC=16208|UniProtKB=Q8WUT4 Q8WUT4 LRRN4 PTHR24366:SF13 IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS LEUCINE-RICH REPEAT NEURONAL PROTEIN 4 cognition#GO:0050890;nervous system process#GO:0050877;multicellular organismal process#GO:0032501;system process#GO:0003008 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 immunoglobulin superfamily cell adhesion molecule#PC00125 HUMAN|HGNC=1686|UniProtKB=P19397 P19397 CD53 PTHR19282:SF39 TETRASPANIN LEUKOCYTE SURFACE ANTIGEN CD53 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HUMAN|HGNC=16722|UniProtKB=Q6NT52 Q6NT52 CGB2 PTHR11515:SF25 GLYCOPROTEIN HORMONE BETA CHAIN CHORIOGONADOTROPIN SUBUNIT BETA 3-RELATED molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;hormone activity#GO:0005179;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545 multicellular organismal process#GO:0032501;gonad development#GO:0008406;biological regulation#GO:0065007;sex differentiation#GO:0007548;cellular process#GO:0009987;signal transduction#GO:0007165;animal organ development#GO:0048513;multicellular organism development#GO:0007275;developmental process#GO:0032502;development of primary sexual characteristics#GO:0045137;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;reproductive process#GO:0022414;reproductive structure development#GO:0048608;signaling#GO:0023052;developmental process involved in reproduction#GO:0003006;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;anatomical structure development#GO:0048856;cell communication#GO:0007154;reproductive system development#GO:0061458;system development#GO:0048731;female gonad development#GO:0008585;animal gross anatomical part developmental process#GO:0160108;G protein-coupled receptor signaling pathway#GO:0007186 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 peptide hormone#PC00179 HUMAN|HGNC=33720|UniProtKB=Q4G0U5 Q4G0U5 CFAP221 PTHR46500:SF1 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 221 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 221 cellular component assembly#GO:0022607;cell projection organization#GO:0030030;plasma membrane bounded cell projection organization#GO:0120036;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cell projection assembly#GO:0030031;motile cilium assembly#GO:0044458;cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782;organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031 cellular anatomical structure#GO:0110165;organelle#GO:0043226;motile cilium#GO:0031514;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;membrane-bounded organelle#GO:0043227;9+2 motile cilium#GO:0097729;cilium#GO:0005929 structural protein#PC00211 HUMAN|HGNC=10660|UniProtKB=O75056 O75056 SDC3 PTHR10915:SF7 SYNDECAN SYNDECAN-3 cell surface#GO:0009986;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=14914|UniProtKB=Q8N1Q1 Q8N1Q1 CA13 PTHR18952:SF81 CARBONIC ANHYDRASE CARBONIC ANHYDRASE 13-RELATED carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;hydro-lyase activity#GO:0016836;catalytic activity#GO:0003824 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 dehydratase#PC00091;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=570|UniProtKB=P53677 P53677 AP3M2 PTHR10529:SF341 AP COMPLEX SUBUNIT MU AP-3 COMPLEX SUBUNIT MU-2 cargo adaptor activity#GO:0140312;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 vacuolar transport#GO:0007034;Golgi vesicle transport#GO:0048193;transport#GO:0006810;intracellular transport#GO:0046907;post-Golgi vesicle-mediated transport#GO:0006892;localization#GO:0051179;cellular localization#GO:0051641;Golgi to vacuole transport#GO:0006896;establishment of localization#GO:0051234;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192 intracellular organelle#GO:0043229;membrane coat#GO:0030117;coated membrane#GO:0048475;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;membrane protein complex#GO:0098796;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;AP-type membrane coat adaptor complex#GO:0030119;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737 membrane traffic protein#PC00150 HUMAN|HGNC=10620|UniProtKB=O00585 O00585 CCL21 PTHR12015:SF72 SMALL INDUCIBLE CYTOKINE A C-C MOTIF CHEMOKINE 21 protein binding#GO:0005515;chemokine receptor binding#GO:0042379;molecular function activator activity#GO:0140677;signaling receptor binding#GO:0005102;binding#GO:0005488;cytokine receptor binding#GO:0005126;cytokine activity#GO:0005125;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;G protein-coupled receptor binding#GO:0001664;chemokine activity#GO:0008009 immune system process#GO:0002376;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;response to peptide#GO:1901652;positive regulation of cell motility#GO:2000147;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;response to stimulus#GO:0050896;granulocyte chemotaxis#GO:0071621;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;antimicrobial humoral response#GO:0019730;humoral immune response#GO:0006959;cell surface receptor signaling pathway#GO:0007166;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;response to chemokine#GO:1990868;cellular process#GO:0009987;defense response to symbiont#GO:0140546;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;defense response to other organism#GO:0098542;granulocyte migration#GO:0097530;response to chemical#GO:0042221;taxis#GO:0042330;response to cytokine#GO:0034097;cytokine-mediated signaling pathway#GO:0019221;chemotaxis#GO:0006935;inflammatory response#GO:0006954;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;chemokine-mediated signaling pathway#GO:0070098;cell communication#GO:0007154;regulation of cell motility#GO:2000145;cell chemotaxis#GO:0060326;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;cell motility#GO:0048870;locomotion#GO:0040011;cellular response to chemokine#GO:1990869;response to external biotic stimulus#GO:0043207;leukocyte migration#GO:0050900;regulation of cell migration#GO:0030334;defense response#GO:0006952;leukocyte chemotaxis#GO:0030595;positive regulation of locomotion#GO:0040017;myeloid leukocyte migration#GO:0097529;response to external stimulus#GO:0009605;positive regulation of cell migration#GO:0030335;immune response#GO:0006955;positive regulation of cellular process#GO:0048522;cell migration#GO:0016477;response to other organism#GO:0051707;regulation of locomotion#GO:0040012;biological regulation#GO:0065007 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 cytokine#PC00083 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CHK#P00856 HUMAN|HGNC=25247|UniProtKB=Q8IYW2 Q8IYW2 CFAP46 PTHR15977:SF15 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 46 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 46 HUMAN|HGNC=12769|UniProtKB=O95388 O95388 CCN4 PTHR11348:SF4 CONNECTIVE TISSUE GROWTH FACTOR-RELATED CCN FAMILY MEMBER 4 glycosaminoglycan binding#GO:0005539;signaling receptor binding#GO:0005102;binding#GO:0005488;protein-containing complex binding#GO:0044877;protein binding#GO:0005515;heparin binding#GO:0008201;cell adhesion molecule binding#GO:0050839;carbohydrate derivative binding#GO:0097367;integrin binding#GO:0005178 positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;biological regulation#GO:0065007;positive regulation of developmental process#GO:0051094;positive regulation of cell differentiation#GO:0045597;regulation of cell differentiation#GO:0045595;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of developmental process#GO:0050793;cell adhesion#GO:0007155;cell communication#GO:0007154 extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207;growth factor#PC00112 HUMAN|HGNC=29044|UniProtKB=O75064 O75064 DENND4B PTHR12296:SF18 DENN DOMAIN-CONTAINING PROTEIN 4 DENN DOMAIN-CONTAINING PROTEIN 4B enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cell communication#GO:0010646;regulation of biological process#GO:0050789;regulation of small GTPase mediated signal transduction#GO:0051056;regulation of intracellular signal transduction#GO:1902531;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular vesicle#GO:0097708;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 protein-binding activity modulator#PC00095;guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=12854|UniProtKB=P27348 P27348 YWHAQ PTHR18860:SF3 14-3-3 PROTEIN 14-3-3 PROTEIN THETA scaffold/adaptor protein#PC00226 Parkinson disease#P00049>14-3-3#P01238;FGF signaling pathway#P00021>14-3-3#P00624;EGF receptor signaling pathway#P00018>14-3-3#P00539 HUMAN|HGNC=15856|UniProtKB=Q9Y2B4 Q9Y2B4 TP53TG5 PTHR15562:SF0 TP53-TARGET GENE 5 PROTEIN TP53-TARGET GENE 5 PROTEIN HUMAN|HGNC=26775|UniProtKB=Q8IY95 Q8IY95 TMEM192 PTHR31592:SF1 TRANSMEMBRANE PROTEIN 192 TRANSMEMBRANE PROTEIN 192 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;lytic vacuole membrane#GO:0098852;intracellular vesicle#GO:0097708;vesicle#GO:0031982;lysosome#GO:0005764;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768;late endosome#GO:0005770;endomembrane system#GO:0012505;vacuole#GO:0005773;cytoplasm#GO:0005737;membrane#GO:0016020;lysosomal membrane#GO:0005765;lytic vacuole#GO:0000323;vacuolar membrane#GO:0005774;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090 HUMAN|HGNC=30320|UniProtKB=Q7Z5H3 Q7Z5H3 ARHGAP22 PTHR15228:SF22 SPERMATHECAL PHYSIOLOGY VARIANT RHO GTPASE-ACTIVATING PROTEIN 22 molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;enzyme activator activity#GO:0008047 negative regulation of intracellular signal transduction#GO:1902532;regulation of synapse structure or activity#GO:0050803;negative regulation of cell communication#GO:0010648;regulation of biological quality#GO:0065008;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;regulation of synapse organization#GO:0050807;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of cell communication#GO:0010646;negative regulation of biological process#GO:0048519;regulation of postsynapse organization#GO:0099175;regulation of biological process#GO:0050789;regulation of small GTPase mediated signal transduction#GO:0051056;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;negative regulation of response to stimulus#GO:0048585;negative regulation of signal transduction#GO:0009968;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966 GTPase-activating protein#PC00257;protein-binding activity modulator#PC00095;G-protein modulator#PC00022 HUMAN|HGNC=14277|UniProtKB=Q9BYD2 Q9BYD2 MRPL9 PTHR21368:SF27 50S RIBOSOMAL PROTEIN L9 LARGE RIBOSOMAL SUBUNIT PROTEIN BL9M structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 mitochondrial gene expression#GO:0140053;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;translation#GO:0006412;metabolic process#GO:0008152;biosynthetic process#GO:0009058;mitochondrial translation#GO:0032543;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238 intracellular anatomical structure#GO:0005622;mitochondrial ribosome#GO:0005761;organellar ribosome#GO:0000313;membrane-bounded organelle#GO:0043227;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;mitochondrion#GO:0005739;organelle lumen#GO:0043233;mitochondrial large ribosomal subunit#GO:0005762;membraneless organelle#GO:0043228;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;membrane-enclosed lumen#GO:0031974 ribosomal protein#PC00202;translational protein#PC00263 HUMAN|HGNC=18336|UniProtKB=Q53EQ6 Q53EQ6 TIGD5 PTHR19303:SF56 TRANSPOSON TIGGER TRANSPOSABLE ELEMENT-DERIVED PROTEIN 5 nucleic acid binding#GO:0003676;binding#GO:0005488;DNA binding#GO:0003677 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 viral or transposable element protein#PC00237 HUMAN|HGNC=26051|UniProtKB=Q9NWY4 Q9NWY4 HPF1 PTHR13386:SF2 HISTONE PARYLATION FACTOR 1 HISTONE PARYLATION FACTOR 1 binding#GO:0005488;carbohydrate derivative binding#GO:0097367;histone binding#GO:0042393;protein binding#GO:0005515 cellular response to stimulus#GO:0051716;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;chromatin remodeling#GO:0006338;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;cellular process#GO:0009987;response to stress#GO:0006950;chromatin organization#GO:0006325;nucleobase-containing compound metabolic process#GO:0006139;DNA damage response#GO:0006974;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;double-strand break repair#GO:0006302;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 histone modifying enzyme#PC00261 HUMAN|HGNC=25281|UniProtKB=Q08ER8 Q08ER8 ZNF543 PTHR24377:SF1042 IP01015P-RELATED ZINC FINGER PROTEIN 543-RELATED RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=15980|UniProtKB=Q96A58 Q96A58 RERG PTHR24070:SF373 RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY RAS-RELATED AND ESTROGEN-REGULATED GROWTH INHIBITOR pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;Ras protein signal transduction#GO:0007265;establishment or maintenance of cell polarity#GO:0007163;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;signaling#GO:0023052;intracellular signaling cassette#GO:0141124;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 small GTPase#PC00208 PDGF signaling pathway#P00047>Ras#P01154 HUMAN|HGNC=1990|UniProtKB=Q8WWK9 Q8WWK9 CKAP2 PTHR16076:SF8 CYTOSKELETON ASSOCIATED PROTEIN 2-RELATED CYTOSKELETON-ASSOCIATED PROTEIN 2 regulation of microtubule-based process#GO:0032886;negative regulation of cytoskeleton organization#GO:0051494;negative regulation of protein-containing complex disassembly#GO:0043242;negative regulation of biological process#GO:0048519;negative regulation of organelle organization#GO:0010639;negative regulation of cellular component organization#GO:0051129;regulation of biological process#GO:0050789;regulation of supramolecular fiber organization#GO:1902903;regulation of organelle organization#GO:0033043;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;negative regulation of supramolecular fiber organization#GO:1902904;regulation of cellular process#GO:0050794;negative regulation of cellular process#GO:0048523;regulation of protein depolymerization#GO:1901879;regulation of microtubule polymerization or depolymerization#GO:0031110;regulation of protein-containing complex disassembly#GO:0043244;biological regulation#GO:0065007;negative regulation of protein depolymerization#GO:1901880;regulation of microtubule cytoskeleton organization#GO:0070507 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226 non-motor microtubule binding protein#PC00166 HUMAN|HGNC=12108|UniProtKB=A0A0B4J241 A0A0B4J241 TRAV13-1 PTHR19433:SF64 T-CELL RECEPTOR ALPHA CHAIN V REGION-RELATED T CELL RECEPTOR ALPHA VARIABLE 13-1 response to bacterium#GO:0009617;response to biotic stimulus#GO:0009607;response to stimulus#GO:0050896;response to other organism#GO:0051707;response to external stimulus#GO:0009605;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=920|UniProtKB=Q9Y2C3 Q9Y2C3 B3GALT5 PTHR11214:SF265 BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE BETA-1,3-GALACTOSYLTRANSFERASE 5 hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740;galactosyltransferase activity#GO:0008378;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757 membrane-bounded organelle#GO:0043227;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020 transferase#PC00220;glycosyltransferase#PC00111 HUMAN|HGNC=10967|UniProtKB=O75751 O75751 SLC22A3 PTHR24064:SF52 SOLUTE CARRIER FAMILY 22 MEMBER SOLUTE CARRIER FAMILY 22 MEMBER 3 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 cellular process#GO:0009987;transport#GO:0006810;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258 HUMAN|HGNC=18504|UniProtKB=Q7L513 Q7L513 FCRLA PTHR11481:SF71 IMMUNOGLOBULIN FC RECEPTOR FC RECEPTOR-LIKE A signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 cell surface receptor signaling pathway#GO:0007166;immune system process#GO:0002376;cell communication#GO:0007154;regulation of biological process#GO:0050789;immune response#GO:0006955;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 membrane#GO:0016020;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell surface#GO:0009986;plasma membrane#GO:0005886 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=4604|UniProtKB=P19876 P19876 CXCL3 PTHR12015:SF196 SMALL INDUCIBLE CYTOKINE A C-X-C MOTIF CHEMOKINE 3 cytokine#PC00083 HUMAN|HGNC=13020|UniProtKB=Q86WZ6 Q86WZ6 ZNF227 PTHR24376:SF232 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 227 gene-specific transcriptional regulator#PC00264;zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=5046|UniProtKB=P52272 P52272 HNRNPM PTHR23003:SF6 RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN M mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 negative regulation of macromolecule metabolic process#GO:0010605;nucleic acid catabolic process#GO:0141188;macromolecule biosynthetic process#GO:0009059;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biosynthetic process#GO:0009058;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;nuclear mRNA surveillance#GO:0071028;negative regulation of cellular process#GO:0048523;rRNA metabolic process#GO:0016072;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;rRNA processing#GO:0006364;cellular process#GO:0009987;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;RNA processing#GO:0006396;gene expression#GO:0010467;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule catabolic process#GO:0009057;cellular component organization or biogenesis#GO:0071840;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;ribonucleoprotein complex biogenesis#GO:0022613;nucleic acid biosynthetic process#GO:0141187;RNA catabolic process#GO:0006401;ribosome biogenesis#GO:0042254;RNA metabolic process#GO:0016070 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 RNA splicing factor#PC00148 HUMAN|HGNC=24251|UniProtKB=Q9Y3A6 Q9Y3A6 TMED5 PTHR22811:SF41 TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN 5 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;cargo adaptor activity#GO:0140312 Golgi organization#GO:0007030;cellular component organization#GO:0016043;protein transport#GO:0015031;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;localization#GO:0051179;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;macromolecule localization#GO:0033036;organelle organization#GO:0006996;endomembrane system organization#GO:0010256;vesicle-mediated transport#GO:0016192;transport#GO:0006810;Golgi vesicle transport#GO:0048193;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840 endoplasmic reticulum#GO:0005783;Golgi apparatus#GO:0005794;cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;coated vesicle#GO:0030135;cytoplasmic vesicle#GO:0031410;COPII-coated ER to Golgi transport vesicle#GO:0030134;vesicle#GO:0031982;intracellular vesicle#GO:0097708;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 vesicle coat protein#PC00235;membrane traffic protein#PC00150 HUMAN|HGNC=18591|UniProtKB=Q8TD19 Q8TD19 NEK9 PTHR44535:SF1 PROTEIN CBG16200 SERINE_THREONINE-PROTEIN KINASE NEK9 catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 cell cycle#GO:0007049;cellular process#GO:0009987;mitotic cell cycle#GO:0000278 HUMAN|HGNC=14315|UniProtKB=O60667 O60667 FCMR PTHR11860:SF59 POLYMERIC-IMMUNOGLOBULIN RECEPTOR IMMUNOGLOBULIN MU FC RECEPTOR transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=379|UniProtKB=Q99996 Q99996 AKAP9 PTHR44981:SF1 PERICENTRIN-LIKE PROTEIN, ISOFORM F A-KINASE ANCHOR PROTEIN 9 protein kinase A regulatory subunit binding#GO:0034237;potassium channel regulator activity#GO:0015459;transporter regulator activity#GO:0141108;binding#GO:0005488;channel regulator activity#GO:0016247;protein binding#GO:0005515;ion channel regulator activity#GO:0099106;protein kinase A binding#GO:0051018;molecular function regulator activity#GO:0098772 cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;microtubule polymerization or depolymerization#GO:0031109;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;microtubule polymerization#GO:0046785;protein-containing complex organization#GO:0043933;centrosome localization#GO:0051642;cellular component organization#GO:0016043;microtubule nucleation#GO:0007020;protein-containing complex assembly#GO:0065003;protein polymerization#GO:0051258;cellular localization#GO:0051641;microtubule cytoskeleton organization#GO:0000226;localization#GO:0051179;supramolecular fiber organization#GO:0097435;organelle localization#GO:0051640 cis-Golgi network#GO:0005801;membraneless organelle#GO:0043228;cell junction#GO:0030054;synaptic membrane#GO:0097060;cytoskeleton#GO:0005856;centrosome#GO:0005813;Golgi apparatus#GO:0005794;microtubule organizing center#GO:0005815;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;endomembrane system#GO:0012505;plasma membrane region#GO:0098590;cell periphery#GO:0071944;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;microtubule cytoskeleton#GO:0015630;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;Golgi stack#GO:0005795 HUMAN|HGNC=24434|UniProtKB=Q49A26 Q49A26 GLYR1 PTHR43580:SF10 OXIDOREDUCTASE GLYR1-RELATED CYTOKINE-LIKE NUCLEAR FACTOR N-PAC nucleic acid binding#GO:0003676;binding#GO:0005488;chromatin binding#GO:0003682;DNA binding#GO:0003677;protein-containing complex binding#GO:0044877;nucleosome binding#GO:0031491 macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;transcription by RNA polymerase II#GO:0006366;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;chromatin organization#GO:0006325;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;transcription elongation by RNA polymerase II#GO:0006368;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;DNA-templated transcription elongation#GO:0006354;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;DNA-templated transcription#GO:0006351;chromatin remodeling#GO:0006338;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043 intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;chromosome#GO:0005694;chromatin#GO:0000785;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232 oxidoreductase#PC00176 HUMAN|HGNC=5188|UniProtKB=Q9NR22 Q9NR22 PRMT8 PTHR11006:SF47 PROTEIN ARGININE N-METHYLTRANSFERASE PROTEIN ARGININE N-METHYLTRANSFERASE 8 methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;N-methyltransferase activity#GO:0008170;histone methyltransferase activity#GO:0042054;histone modifying activity#GO:0140993;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein methyltransferase activity#GO:0008276;catalytic activity, acting on a protein#GO:0140096 regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;chromatin remodeling#GO:0006338;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;chromatin organization#GO:0006325;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;nucleus#GO:0005634 protein modifying enzyme#PC00260 HUMAN|HGNC=20510|UniProtKB=P62805 P62805 H4C1 PTHR10484:SF210 HISTONE H4 HISTONE H4 structural molecule activity#GO:0005198 chromatin remodeling#GO:0006338;chromatin organization#GO:0006325;protein-DNA complex assembly#GO:0065004;cellular component assembly#GO:0022607;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;protein-containing complex organization#GO:0043933;protein-DNA complex organization#GO:0071824;nucleosome organization#GO:0034728;cellular component organization or biogenesis#GO:0071840 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=18287|UniProtKB=Q86XT2 Q86XT2 VPS37D PTHR13678:SF12 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37D protein targeting to vacuole#GO:0006623;establishment of protein localization to membrane#GO:0090150;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;macromolecule catabolic process#GO:0009057;protein targeting to membrane#GO:0006612;metabolic process#GO:0008152;intracellular protein transport#GO:0006886;protein targeting#GO:0006605;establishment of protein localization to vacuole#GO:0072666;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;cellular localization#GO:0051641;protein transport#GO:0015031;macromolecule localization#GO:0033036;ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043162;intracellular transport#GO:0046907;transport#GO:0006810;vacuolar transport#GO:0007034;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;intracellular protein localization#GO:0008104;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;protein localization to organelle#GO:0033365;catabolic process#GO:0009056;protein localization to vacuole#GO:0072665;localization within membrane#GO:0051668;protein metabolic process#GO:0019538;localization#GO:0051179 bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;vesicle membrane#GO:0012506;membrane#GO:0016020;ESCRT I complex#GO:0000813;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endosome#GO:0005768;endosome membrane#GO:0010008;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708 membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=11369|UniProtKB=P02808 P02808 STATH PTHR15057:SF3 STATHERIN STATHERIN antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;immune system process#GO:0002376;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to stimulus#GO:0050896;response to external stimulus#GO:0009605;defense response#GO:0006952;antimicrobial humoral response#GO:0019730;cell killing#GO:0001906;humoral immune response#GO:0006959;response to other organism#GO:0051707;defense response to other organism#GO:0098542;defense response to symbiont#GO:0140546;immune response#GO:0006955;cellular process#GO:0009987;response to biotic stimulus#GO:0009607;response to stress#GO:0006950 mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;extracellular region#GO:0005576;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=14465|UniProtKB=Q96T54 Q96T54 KCNK17 PTHR11003:SF340 POTASSIUM CHANNEL, SUBFAMILY K POTASSIUM CHANNEL SUBFAMILY K MEMBER 17 voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;potassium channel activity#GO:0005267;outward rectifier potassium channel activity#GO:0015271;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261 monoatomic ion transport#GO:0006811;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;transport#GO:0006810;monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133;transporter#PC00227 HUMAN|HGNC=4272|UniProtKB=Q9Y2X7 Q9Y2X7 GIT1 PTHR46097:SF1 G PROTEIN-COUPLED RECEPTOR KINASE INTERACTING ARFGAP ARF GTPASE-ACTIVATING PROTEIN GIT1 molecular function activator activity#GO:0140677;small GTPase binding#GO:0031267;enzyme regulator activity#GO:0030234;protein binding#GO:0005515;enzyme binding#GO:0019899;binding#GO:0005488;molecular function regulator activity#GO:0098772;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047 regulation of response to stimulus#GO:0048583;synaptic vesicle cycle#GO:0099504;transport#GO:0006810;regulation of G protein-coupled receptor signaling pathway#GO:0008277;developmental process#GO:0032502;regulation of small GTPase mediated signal transduction#GO:0051056;vesicle-mediated transport in synapse#GO:0099003;establishment of localization#GO:0051234;animal organ development#GO:0048513;multicellular organism development#GO:0007275;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;nervous system development#GO:0007399;head development#GO:0060322;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;synaptic vesicle recycling#GO:0036465;vesicle-mediated transport#GO:0016192;multicellular organismal process#GO:0032501;brain development#GO:0007420;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;anatomical structure development#GO:0048856;cellular localization#GO:0051641;localization#GO:0051179;regulation of biological process#GO:0050789;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;central nervous system development#GO:0007417 cytosol#GO:0005829;postsynapse#GO:0098794;neuron projection#GO:0043005;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;cell junction#GO:0030054;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=29434|UniProtKB=Q5TC82 Q5TC82 RC3H1 PTHR13139:SF6 RING FINGER AND CCCH-TYPE ZINC FINGER DOMAIN-CONTAINING PROTEIN ROQUIN-1 catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin protein ligase activity#GO:0061630;double-stranded RNA binding#GO:0003725;ubiquitin-like protein transferase activity#GO:0019787;binding#GO:0005488;nucleic acid binding#GO:0003676;acyltransferase activity#GO:0016746;mRNA binding#GO:0003729;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;RNA binding#GO:0003723 regulation of mRNA metabolic process#GO:1903311;positive regulation of mRNA metabolic process#GO:1903313;mRNA destabilization#GO:0061157;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;protein ubiquitination#GO:0016567;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;RNA destabilization#GO:0050779;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of biological quality#GO:0065008;RNA metabolic process#GO:0016070;positive regulation of metabolic process#GO:0009893;modification-dependent macromolecule catabolic process#GO:0043632;RNA catabolic process#GO:0006401;protein catabolic process#GO:0030163;protein modification by small protein conjugation or removal#GO:0070647;regulation of mRNA stability#GO:0043488;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;ubiquitin-dependent protein catabolic process#GO:0006511;positive regulation of catabolic process#GO:0009896;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;macromolecule metabolic process#GO:0043170;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;post-translational protein modification#GO:0043687;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;nucleic acid catabolic process#GO:0141188;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;nucleobase-containing compound catabolic process#GO:0034655;regulation of RNA metabolic process#GO:0051252;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;regulation of RNA stability#GO:0043487;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;positive regulation of mRNA catabolic process#GO:0061014;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;protein modification process#GO:0036211 supramolecular complex#GO:0099080;organelle#GO:0043226;ribonucleoprotein granule#GO:0035770;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;membraneless organelle#GO:0043228;cytoplasmic stress granule#GO:0010494;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=20260|UniProtKB=Q96IW7 Q96IW7 SEC22A PTHR46258:SF3 LONGIN DOMAIN-CONTAINING PROTEIN VESICLE-TRAFFICKING PROTEIN SEC22A vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;intracellular transport#GO:0046907;transport#GO:0006810;Golgi vesicle transport#GO:0048193 HUMAN|HGNC=11298|UniProtKB=Q9H3Y6 Q9H3Y6 SRMS PTHR24418:SF23 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE SRMS protein tyrosine kinase activity#GO:0004713;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;signaling receptor binding#GO:0005102;binding#GO:0005488;non-membrane spanning protein tyrosine kinase activity#GO:0004715;protein binding#GO:0005515;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;developmental process#GO:0032502;cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;cellular developmental process#GO:0048869 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 non-receptor tyrosine protein kinase#PC00168 HUMAN|HGNC=6813|UniProtKB=Q9Y5V3 Q9Y5V3 MAGED1 PTHR11736:SF28 MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN MELANOMA-ASSOCIATED ANTIGEN D1 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 scaffold/adaptor protein#PC00226 HUMAN|HGNC=6451|UniProtKB=Q14525 Q14525 KRT33B PTHR23239:SF99 INTERMEDIATE FILAMENT KERATIN, TYPE I CUTICULAR HA3-II structural molecule activity#GO:0005198 cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;morphogenesis of an epithelium#GO:0002009;developmental process#GO:0032502;epithelium development#GO:0060429;tissue development#GO:0009888;epithelial cell differentiation#GO:0030855;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular process#GO:0009987;tissue morphogenesis#GO:0048729;anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;intermediate filament-based process#GO:0045103;animal gross anatomical part developmental process#GO:0160108;intermediate filament organization#GO:0045109;intermediate filament cytoskeleton organization#GO:0045104;cell differentiation#GO:0030154;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;intermediate filament#GO:0005882;supramolecular fiber#GO:0099512;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;organelle#GO:0043226;supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232 intermediate filament#PC00129 HUMAN|HGNC=29832|UniProtKB=Q6IA69 Q6IA69 NADSYN1 PTHR23090:SF9 NH 3 /GLUTAMINE-DEPENDENT NAD + SYNTHETASE GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE ligase activity, forming carbon-nitrogen bonds#GO:0016879;catalytic activity#GO:0003824;ligase activity#GO:0016874 nicotinamide nucleotide metabolic process#GO:0046496;cellular process#GO:0009987;NAD+ metabolic process#GO:0019674;organophosphate metabolic process#GO:0019637;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;amino acid metabolic process#GO:0006520;proteinogenic amino acid metabolic process#GO:0170039;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleobase-containing small molecule metabolic process#GO:0055086;nucleoside phosphate biosynthetic process#GO:1901293;purine nucleotide metabolic process#GO:0006163;indole-containing compound metabolic process#GO:0042430;purine-containing compound metabolic process#GO:0072521;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;carboxylic acid metabolic process#GO:0019752;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;pyridine-containing compound metabolic process#GO:0072524;purine nucleotide biosynthetic process#GO:0006164;oxoacid metabolic process#GO:0043436;purine-containing compound biosynthetic process#GO:0072522;nucleotide biosynthetic process#GO:0009165;nucleotide metabolic process#GO:0009117;organophosphate biosynthetic process#GO:0090407 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 ligase#PC00142 HUMAN|HGNC=3394|UniProtKB=P54753 P54753 EPHB3 PTHR46877:SF6 EPH RECEPTOR A5 EPHRIN TYPE-B RECEPTOR 3 protein kinase activity#GO:0004672;molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane signaling receptor activity#GO:0004888;transmembrane receptor protein kinase activity#GO:0019199;signaling receptor activity#GO:0038023;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;protein tyrosine kinase activity#GO:0004713;catalytic activity#GO:0003824;transferase activity#GO:0016740 neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;neuron projection guidance#GO:0097485;axon development#GO:0061564;axon guidance#GO:0007411;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;cell communication#GO:0007154;system development#GO:0048731;cellular response to stimulus#GO:0051716;ephrin receptor signaling pathway#GO:0048013;regulation of cellular process#GO:0050794;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell surface receptor signaling pathway#GO:0007166;neuron differentiation#GO:0030182;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cell projection morphogenesis#GO:0048858;neuron projection development#GO:0031175;cellular process#GO:0009987;signal transduction#GO:0007165;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;axonogenesis#GO:0007409;neuron development#GO:0048666;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;cell differentiation#GO:0030154;response to stimulus#GO:0050896;cell development#GO:0048468;signaling#GO:0023052 dendrite#GO:0030425;dendritic tree#GO:0097447;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;somatodendritic compartment#GO:0036477;cell projection#GO:0042995;plasma membrane#GO:0005886;plasma membrane bounded cell projection#GO:0120025 transmembrane signal receptor#PC00197 Angiogenesis#P00005>EphR#P00212 HUMAN|HGNC=17692|UniProtKB=Q9HAT0 Q9HAT0 ROPN1 PTHR14952:SF18 ROPPORIN-1-LIKE PROTEIN ROPPORIN-1A cell differentiation#GO:0030154;gamete generation#GO:0007276;cell motility#GO:0048870;microtubule-based movement#GO:0007018;cellular process involved in reproduction in multicellular organism#GO:0022412;reproductive process#GO:0022414;cell development#GO:0048468;developmental process involved in reproduction#GO:0003006;anatomical structure maturation#GO:0071695;germ cell development#GO:0007281;sperm motility#GO:0097722;cilium-dependent cell motility#GO:0060285;anatomical structure development#GO:0048856;multicellular organismal reproductive process#GO:0048609;spermatid differentiation#GO:0048515;cilium or flagellum-dependent cell motility#GO:0001539;sexual reproduction#GO:0019953;cilium movement#GO:0003341;spermatid development#GO:0007286;developmental maturation#GO:0021700;male gamete generation#GO:0048232;sperm capacitation#GO:0048240;cilium movement involved in cell motility#GO:0060294;cellular process#GO:0009987;cell maturation#GO:0048469;cellular developmental process#GO:0048869;microtubule-based process#GO:0007017;flagellated sperm motility#GO:0030317;developmental process#GO:0032502;spermatogenesis#GO:0007283 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cilium#GO:0005929;motile cilium#GO:0031514;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737 HUMAN|HGNC=30832|UniProtKB=Q96Q05 Q96Q05 TRAPPC9 PTHR21512:SF5 TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9 TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9 enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 retrograde transport, endosome to Golgi#GO:0042147;cellular process#GO:0009987;intra-Golgi vesicle-mediated transport#GO:0006891;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;cytosolic transport#GO:0016482;intracellular transport#GO:0046907;transport#GO:0006810;Golgi vesicle transport#GO:0048193;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;endosomal transport#GO:0016197 intracellular vesicle#GO:0097708;TRAPPII protein complex#GO:1990071;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;Golgi apparatus subcompartment#GO:0098791;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasm#GO:0005737;TRAPP complex#GO:0030008;trans-Golgi network#GO:0005802;Golgi apparatus#GO:0005794;intracellular protein-containing complex#GO:0140535;vesicle tethering complex#GO:0099023 HUMAN|HGNC=20713|UniProtKB=Q8WVZ1 Q8WVZ1 ZDHHC19 PTHR22883:SF326 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE ZDHHC19 catalytic activity, acting on a protein#GO:0140096;palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746 vesicle organization#GO:0016050;establishment of localization#GO:0051234;synaptic vesicle maturation#GO:0016188;cellular component organization or biogenesis#GO:0071840;developmental process#GO:0032502;protein targeting to membrane#GO:0006612;developmental maturation#GO:0021700;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of protein localization to membrane#GO:0090150;organelle organization#GO:0006996;cellular localization#GO:0051641;localization#GO:0051179;localization within membrane#GO:0051668;protein targeting#GO:0006605;cellular component organization#GO:0016043 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HUMAN|HGNC=1759|UniProtKB=P19022 P19022 CDH2 PTHR24027:SF79 CADHERIN-23 CADHERIN-2 binding#GO:0005488;cell adhesion molecule binding#GO:0050839;protein binding#GO:0005515;beta-catenin binding#GO:0008013 cell motility#GO:0048870;cell junction organization#GO:0034330;synapse assembly#GO:0007416;cell junction assembly#GO:0034329;cellular component organization#GO:0016043;system development#GO:0048731;anatomical structure development#GO:0048856;cell adhesion#GO:0007155;synapse organization#GO:0050808;animal gross anatomical part developmental process#GO:0160108;nervous system development#GO:0007399;cellular component assembly#GO:0022607;cell migration#GO:0016477;multicellular organismal process#GO:0032501;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;cell-cell adhesion#GO:0098609;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;developmental process#GO:0032502 plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165;intercalated disc#GO:0014704;anchoring junction#GO:0070161;intracellular anatomical structure#GO:0005622;neuron projection#GO:0043005;cell periphery#GO:0071944;cell leading edge#GO:0031252;cell-cell junction#GO:0005911;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;lamellipodium#GO:0030027;protein-containing complex#GO:0032991;apical part of cell#GO:0045177;cell-cell contact zone#GO:0044291;extrinsic component of membrane#GO:0019898;cell junction#GO:0030054;extrinsic component of plasma membrane#GO:0019897 cell adhesion molecule#PC00069;cadherin#PC00057 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HUMAN|HGNC=30844|UniProtKB=Q6UXD5 Q6UXD5 SEZ6L2 PTHR45656:SF2 PROTEIN CBR-CLEC-78 SEIZURE 6-LIKE PROTEIN 2 cell junction organization#GO:0034330;multicellular organismal process#GO:0032501;developmental maturation#GO:0021700;nervous system development#GO:0007399;cellular component organization#GO:0016043;cellular process#GO:0009987;anatomical structure development#GO:0048856;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502;synapse organization#GO:0050808 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cell body#GO:0044297;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;neuronal cell body#GO:0043025;somatodendritic compartment#GO:0036477;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=24430|UniProtKB=Q01546 Q01546 KRT76 PTHR45616:SF29 GATA-TYPE DOMAIN-CONTAINING PROTEIN KERATIN, TYPE II CYTOSKELETAL 2 ORAL structural molecule activity#GO:0005198 intermediate filament cytoskeleton organization#GO:0045104;cell differentiation#GO:0030154;cellular component organization#GO:0016043;supramolecular fiber organization#GO:0097435;anatomical structure development#GO:0048856;intermediate filament organization#GO:0045109;keratinocyte differentiation#GO:0030216;animal gross anatomical part developmental process#GO:0160108;intermediate filament-based process#GO:0045103;cytoskeleton organization#GO:0007010;skin development#GO:0043588;tissue development#GO:0009888;multicellular organismal process#GO:0032501;epidermal cell differentiation#GO:0009913;epithelial cell differentiation#GO:0030855;epithelium development#GO:0060429;cellular process#GO:0009987;organelle organization#GO:0006996;animal organ development#GO:0048513;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;developmental process#GO:0032502;epidermis development#GO:0008544 organelle#GO:0043226;supramolecular complex#GO:0099080;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;intermediate filament#GO:0005882;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=21642|UniProtKB=Q5ST30 Q5ST30 VARS2 PTHR11946:SF71 VALYL-TRNA SYNTHETASES VALINE--TRNA LIGASE, MITOCHONDRIAL catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098;ligase activity#GO:0016874;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;macromolecule metabolic process#GO:0043170;amino acid activation#GO:0043038;tRNA aminoacylation#GO:0043039;tRNA aminoacylation for protein translation#GO:0006418;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;amino acid metabolic process#GO:0006520;translation#GO:0006412;RNA metabolic process#GO:0016070;protein metabolic process#GO:0019538;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;protein biosynthetic process#GO:0160307 aminoacyl-tRNA synthetase#PC00047 HUMAN|HGNC=16644|UniProtKB=A6NNB3 A6NNB3 IFITM5 PTHR13999:SF10 INTERFERON INDUCIBLE TRANSMEMBRANE PROTEIN INTERFERON-INDUCED TRANSMEMBRANE PROTEIN 5 multicellular organism development#GO:0007275;animal organ development#GO:0048513;bone mineralization#GO:0030282;developmental process#GO:0032502;tissue development#GO:0009888;multicellular organismal process#GO:0032501;skeletal system morphogenesis#GO:0048705;bone development#GO:0060348;skeletal system development#GO:0001501;anatomical structure development#GO:0048856;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;biomineral tissue development#GO:0031214;animal organ morphogenesis#GO:0009887;ossification#GO:0001503;anatomical structure morphogenesis#GO:0009653 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090 HUMAN|HGNC=26954|UniProtKB=Q8NBR6 Q8NBR6 MINDY2 PTHR18063:SF8 NF-E2 INDUCIBLE PROTEIN UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MINDY-2 catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;carboxypeptidase activity#GO:0004180 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=3354|UniProtKB=P13929 P13929 ENO3 PTHR11902:SF5 ENOLASE BETA-ENOLASE carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;hydro-lyase activity#GO:0016836;catalytic activity#GO:0003824;phosphopyruvate hydratase activity#GO:0004634 phosphorus metabolic process#GO:0006793;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;ribonucleoside diphosphate metabolic process#GO:0009185;pyridine-containing compound catabolic process#GO:0072526;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;small molecule metabolic process#GO:0044281;pyridine nucleotide catabolic process#GO:0019364;pyruvate metabolic process#GO:0006090;purine nucleoside diphosphate metabolic process#GO:0009135;ribonucleotide metabolic process#GO:0009259;oxoacid metabolic process#GO:0043436;carbohydrate catabolic process#GO:0016052;nucleotide metabolic process#GO:0009117;cellular process#GO:0009987;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;nicotinamide nucleotide metabolic process#GO:0046496;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;ADP catabolic process#GO:0046032;purine-containing compound catabolic process#GO:0072523;purine nucleoside diphosphate catabolic process#GO:0009137;nucleobase-containing small molecule metabolic process#GO:0055086;primary metabolic process#GO:0044238;purine nucleoside triphosphate metabolic process#GO:0009144;nucleoside diphosphate catabolic process#GO:0009134;purine ribonucleotide catabolic process#GO:0009154;nucleoside phosphate catabolic process#GO:1901292;catabolic process#GO:0009056;nucleoside phosphate metabolic process#GO:0006753;carbohydrate derivative catabolic process#GO:1901136;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate metabolic process#GO:0005975;nucleoside diphosphate metabolic process#GO:0009132;purine nucleotide catabolic process#GO:0006195;pyridine-containing compound metabolic process#GO:0072524;cellular respiration#GO:0045333;ribonucleoside diphosphate catabolic process#GO:0009191;organophosphate catabolic process#GO:0046434;purine ribonucleoside diphosphate catabolic process#GO:0009181;aerobic respiration#GO:0009060;organophosphate metabolic process#GO:0019637;nucleobase-containing compound catabolic process#GO:0034655;glycolytic process#GO:0006096;purine ribonucleoside triphosphate metabolic process#GO:0009205;ribonucleotide catabolic process#GO:0009261;carbohydrate derivative metabolic process#GO:1901135;nucleobase-containing compound metabolic process#GO:0006139;nucleotide catabolic process#GO:0009166;purine ribonucleoside diphosphate metabolic process#GO:0009179;generation of precursor metabolites and energy#GO:0006091;energy derivation by oxidation of organic compounds#GO:0015980;ADP metabolic process#GO:0046031 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;catalytic complex#GO:1902494 metabolite interconversion enzyme#PC00262;lyase#PC00144 HUMAN|HGNC=13603|UniProtKB=Q8N531 Q8N531 FBXL6 PTHR16134:SF28 F-BOX/TPR REPEAT PROTEIN POF3 F-BOX_LRR-REPEAT PROTEIN 6 ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238 catalytic complex#GO:1902494;transferase complex#GO:1990234;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;cullin-RING ubiquitin ligase complex#GO:0031461;SCF ubiquitin ligase complex#GO:0019005;intracellular protein-containing complex#GO:0140535 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=14000|UniProtKB=Q9HAZ2 Q9HAZ2 PRDM16 PTHR24393:SF171 ZINC FINGER PROTEIN HISTONE-LYSINE N-METHYLTRANSFERASE PRDM16 transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription activator activity#GO:0001216;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;sequence-specific DNA binding#GO:0043565;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;sequence-specific double-stranded DNA binding#GO:1990837;transcription coregulator activity#GO:0003712 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=15955|UniProtKB=Q53EL9 Q53EL9 SEZ6 PTHR45656:SF1 PROTEIN CBR-CLEC-78 SEIZURE PROTEIN 6 HOMOLOG developmental maturation#GO:0021700;brain development#GO:0007420;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;head development#GO:0060322;nervous system development#GO:0007399;regulation of neuron projection development#GO:0010975;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;regulation of plasma membrane bounded cell projection organization#GO:0120035;multicellular organism development#GO:0007275;animal organ development#GO:0048513;regulation of cell projection organization#GO:0031344;developmental process#GO:0032502;regulation of cellular component organization#GO:0051128;central nervous system development#GO:0007417;regulation of dendrite development#GO:0050773;cell junction organization#GO:0034330;regulation of cellular process#GO:0050794;regulation of developmental process#GO:0050793;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;anatomical structure development#GO:0048856;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;synapse organization#GO:0050808 cytoplasm#GO:0005737;somatodendritic compartment#GO:0036477;endomembrane system#GO:0012505;neuron projection#GO:0043005;cell junction#GO:0030054;endoplasmic reticulum#GO:0005783;intracellular membrane-bounded organelle#GO:0043231;neuron spine#GO:0044309;plasma membrane bounded cell projection#GO:0120025;neuronal cell body#GO:0043025;cell projection#GO:0042995;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;dendritic spine#GO:0043197;cell body#GO:0044297;postsynapse#GO:0098794;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;dendritic tree#GO:0097447;intracellular organelle#GO:0043229;dendrite#GO:0030425 HUMAN|Ensembl=ENSG00000283599.3|UniProtKB=A0A1B0GV59 A0A1B0GV59 LOC101059915 PTHR31866:SF3 GENE 4779-RELATED SUBFAMILY NOT NAMED HUMAN|HGNC=28291|UniProtKB=Q96NB3 Q96NB3 ZNF830 PTHR13278:SF0 ZINC FINGER PROTEIN 830 ZINC FINGER PROTEIN 830 biological regulation#GO:0065007;mitotic G2/M transition checkpoint#GO:0044818;mitotic DNA integrity checkpoint signaling#GO:0044774;regulation of mitotic cell cycle#GO:0007346;regulation of cell cycle G2/M phase transition#GO:1902749;DNA integrity checkpoint signaling#GO:0031570;mitotic cell cycle process#GO:1903047;negative regulation of cell cycle process#GO:0010948;negative regulation of cellular process#GO:0048523;mitotic cell cycle#GO:0000278;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;cell cycle#GO:0007049;mitotic cell cycle checkpoint signaling#GO:0007093;regulation of cell cycle phase transition#GO:1901987;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;regulation of G2/M transition of mitotic cell cycle#GO:0010389;regulation of cell cycle process#GO:0010564;negative regulation of mitotic cell cycle phase transition#GO:1901991;cell cycle checkpoint signaling#GO:0000075;negative regulation of G2/M transition of mitotic cell cycle#GO:0010972;signal transduction#GO:0007165;cellular process#GO:0009987;negative regulation of cell cycle G2/M phase transition#GO:1902750;DNA replication checkpoint signaling#GO:0000076;negative regulation of cell cycle#GO:0045786;signaling#GO:0023052;regulation of cell cycle#GO:0051726;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;cell cycle process#GO:0022402;mitotic DNA replication checkpoint signaling#GO:0033314;negative regulation of biological process#GO:0048519;negative regulation of cell cycle phase transition#GO:1901988;negative regulation of mitotic cell cycle#GO:0045930;regulation of mitotic cell cycle phase transition#GO:1901990 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=29548|UniProtKB=Q9BQ95 Q9BQ95 ECSIT PTHR13113:SF1 ECSIT EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAYS EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAY, MITOCHONDRIAL cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of immune response#GO:0050776;regulation of defense response#GO:0031347;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;response to external biotic stimulus#GO:0043207;immune response-activating cell surface receptor signaling pathway#GO:0002429;regulation of response to biotic stimulus#GO:0002831;innate immune response-activating signaling pathway#GO:0002758;cellular response to stimulus#GO:0051716;regulation of innate immune response#GO:0045088;innate immune response#GO:0045087;response to external stimulus#GO:0009605;positive regulation of response to biotic stimulus#GO:0002833;pattern recognition receptor signaling pathway#GO:0002221;defense response#GO:0006952;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;regulation of response to stress#GO:0080134;positive regulation of immune response#GO:0050778;positive regulation of defense response#GO:0031349;regulation of response to stimulus#GO:0048583;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;toll-like receptor 4 signaling pathway#GO:0034142;immune response-regulating cell surface receptor signaling pathway#GO:0002768;response to other organism#GO:0051707;activation of innate immune response#GO:0002218;immune response#GO:0006955;positive regulation of innate immune response#GO:0045089;immune system process#GO:0002376;response to stimulus#GO:0050896;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;regulation of biological process#GO:0050789;immune response-regulating signaling pathway#GO:0002764;immune response-activating signaling pathway#GO:0002757;positive regulation of response to external stimulus#GO:0032103;cell surface receptor signaling pathway#GO:0007166;regulation of response to external stimulus#GO:0032101;defense response to other organism#GO:0098542;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;positive regulation of immune system process#GO:0002684;defense response to symbiont#GO:0140546;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;cellular process#GO:0009987 mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 scaffold/adaptor protein#PC00226 Toll receptor signaling pathway#P00054>ECSIT#P01349 HUMAN|HGNC=15860|UniProtKB=O94906 O94906 PRPF6 PTHR11246:SF1 PRE-MRNA SPLICING FACTOR PRE-MRNA-PROCESSING FACTOR 6 cellular component organization#GO:0016043;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;protein-containing complex assembly#GO:0065003;mRNA splicing, via spliceosome#GO:0000398;spliceosomal snRNP assembly#GO:0000387;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;ribonucleoprotein complex biogenesis#GO:0022613;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;protein-RNA complex assembly#GO:0022618;RNA metabolic process#GO:0016070;mRNA processing#GO:0006397;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component assembly#GO:0022607;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-RNA complex organization#GO:0071826;protein-containing complex organization#GO:0043933 catalytic complex#GO:1902494;intracellular organelle#GO:0043229;spliceosomal tri-snRNP complex#GO:0097526;ribonucleoprotein complex#GO:1990904;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;spliceosomal snRNP complex#GO:0097525;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear protein-containing complex#GO:0140513;Sm-like protein family complex#GO:0120114;catalytic step 2 spliceosome#GO:0071013;nucleus#GO:0005634;small nuclear ribonucleoprotein complex#GO:0030532;U4/U6 x U5 tri-snRNP complex#GO:0046540;protein-containing complex#GO:0032991 RNA splicing factor#PC00148;RNA processing factor#PC00147 HUMAN|HGNC=4087|UniProtKB=P18507 P18507 GABRG2 PTHR18945:SF498 NEUROTRANSMITTER GATED ION CHANNEL GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT GAMMA-2 transmembrane signaling receptor activity#GO:0004888;gated channel activity#GO:0022836;ligand-gated monoatomic ion channel activity#GO:0015276;channel activity#GO:0015267;molecular transducer activity#GO:0060089;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;neurotransmitter receptor activity#GO:0030594;signaling receptor activity#GO:0038023;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion channel activity#GO:0005216;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;monoatomic ion transmembrane transporter activity#GO:0015075 chloride transmembrane transport#GO:1902476;cell communication#GO:0007154;localization#GO:0051179;anatomical structure development#GO:0048856;system development#GO:0048731;trans-synaptic signaling#GO:0099537;synapse organization#GO:0050808;anterograde trans-synaptic signaling#GO:0098916;cell junction organization#GO:0034330;monoatomic anion transport#GO:0006820;chemical synaptic transmission#GO:0007268;establishment of localization#GO:0051234;developmental process#GO:0032502;transport#GO:0006810;multicellular organismal process#GO:0032501;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;transmembrane transport#GO:0055085;inorganic anion transport#GO:0015698;monoatomic ion transport#GO:0006811;animal gross anatomical part developmental process#GO:0160108;synapse assembly#GO:0007416;signaling#GO:0023052;cell junction assembly#GO:0034329;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;chloride transport#GO:0006821;cellular component assembly#GO:0022607;monoatomic anion transmembrane transport#GO:0098656;nervous system development#GO:0007399;cellular component biogenesis#GO:0044085;synaptic signaling#GO:0099536;cellular process#GO:0009987 cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;synapse#GO:0045202;cellular anatomical structure#GO:0110165;postsynapse#GO:0098794;cell projection membrane#GO:0031253;leading edge membrane#GO:0031256;dendritic tree#GO:0097447;dendrite#GO:0030425;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;plasma membrane region#GO:0098590;protein-containing complex#GO:0032991;neuron projection#GO:0043005;cell periphery#GO:0071944;cell leading edge#GO:0031252;membrane#GO:0016020;cell junction#GO:0030054;neuron projection membrane#GO:0032589;signaling receptor complex#GO:0043235 ligand-gated ion channel#PC00141 HUMAN|HGNC=25609|UniProtKB=Q32MH5 Q32MH5 ATOSA PTHR13199:SF13 GH03947P ATOS HOMOLOG PROTEIN A HUMAN|HGNC=18947|UniProtKB=Q3MIV0 Q3MIV0 KRTAP22-1 PTHR39653:SF2 KERATIN-ASSOCIATED PROTEIN 20-2 KERATIN-ASSOCIATED PROTEIN 22-1 structural protein#PC00211 HUMAN|Ensembl=ENSG00000215156.6|UniProtKB=A0ABB0MVG0 A0ABB0MVG0 LOC124906495 PTHR15566:SF4 POM121-LIKE POM121-LIKE PROTEIN 1-RELATED HUMAN|HGNC=12904|UniProtKB=P58317 P58317 ZNF121 PTHR24377:SF1016 IP01015P-RELATED ZINC FINGER PROTEIN 121 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=16275|UniProtKB=Q9C037 Q9C037 TRIM4 PTHR24103:SF670 E3 UBIQUITIN-PROTEIN LIGASE TRIM E3 UBIQUITIN-PROTEIN LIGASE TRIM4 ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 response to biotic stimulus#GO:0009607;regulation of macromolecule biosynthetic process#GO:0010556;response to stress#GO:0006950;regulation of metabolic process#GO:0019222;immune response#GO:0006955;defense response to symbiont#GO:0140546;defense response to other organism#GO:0098542;biological regulation#GO:0065007;response to other organism#GO:0051707;regulation of biosynthetic process#GO:0009889;innate immune response#GO:0045087;response to external stimulus#GO:0009605;defense response#GO:0006952;regulation of gene expression#GO:0010468;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;immune system process#GO:0002376 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=21769|UniProtKB=Q9UFC0 Q9UFC0 LRWD1 PTHR24370:SF10 OPTICIN LEUCINE-RICH REPEAT AND WD REPEAT-CONTAINING PROTEIN 1 extracellular matrix protein#PC00102 HUMAN|HGNC=8764|UniProtKB=O14737 O14737 PDCD5 PTHR10840:SF1 PROGRAMMED CELL DEATH PROTEIN 5 PROGRAMMED CELL DEATH PROTEIN 5 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cytosol#GO:0005829;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 protein-binding activity modulator#PC00095 HUMAN|HGNC=13093|UniProtKB=P17040 P17040 ZSCAN20 PTHR23226:SF440 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 20 binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=1970|UniProtKB=Q9Y4C5 Q9Y4C5 CHST2 PTHR10704:SF3 CARBOHYDRATE SULFOTRANSFERASE CARBOHYDRATE SULFOTRANSFERASE 2 sulfotransferase activity#GO:0008146;transferase activity, transferring sulphur-containing groups#GO:0016782;catalytic activity#GO:0003824;transferase activity#GO:0016740 amino sugar metabolic process#GO:0006040;sulfur compound metabolic process#GO:0006790;metabolic process#GO:0008152;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135 intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;trans-Golgi network#GO:0005802;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;Golgi apparatus subcompartment#GO:0098791 metabolite interconversion enzyme#PC00262;transferase#PC00220 HUMAN|HGNC=11406|UniProtKB=Q13188 Q13188 STK3 PTHR48015:SF23 SERINE/THREONINE-PROTEIN KINASE TAO SERINE_THREONINE-PROTEIN KINASE 3 catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674 regulation of apoptotic process#GO:0042981;regulation of MAPK cascade#GO:0043408;positive regulation of apoptotic process#GO:0043065;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;regulation of canonical Wnt signaling pathway#GO:0060828;negative regulation of signal transduction#GO:0009968;hippo signaling#GO:0035329;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;negative regulation of canonical Wnt signaling pathway#GO:0090090;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648;regulation of biological process#GO:0050789;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;regulation of Wnt signaling pathway#GO:0030111;signaling#GO:0023052;positive regulation of programmed cell death#GO:0043068;response to stimulus#GO:0050896;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;positive regulation of cellular process#GO:0048522;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of response to stimulus#GO:0048585;negative regulation of Wnt signaling pathway#GO:0030178;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=1471|UniProtKB=P49069 P49069 CAMLG PTHR15026:SF0 CALCIUM-SIGNAL MODULATING CYCLOPHILIN LIGAND CAML GUIDED ENTRY OF TAIL-ANCHORED PROTEINS FACTOR CAMLG localization within membrane#GO:0051668;localization#GO:0051179;cellular localization#GO:0051641;protein insertion into ER membrane#GO:0045048;endoplasmic reticulum organization#GO:0007029;cellular component organization#GO:0016043;protein localization to organelle#GO:0033365;intracellular protein localization#GO:0008104;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;establishment of protein localization#GO:0045184;cellular process#GO:0009987;establishment of protein localization to membrane#GO:0090150;organelle organization#GO:0006996;macromolecule localization#GO:0033036;membrane organization#GO:0061024;endomembrane system organization#GO:0010256;protein insertion into membrane#GO:0051205;tail-anchored membrane protein insertion into ER membrane#GO:0071816 intracellular anatomical structure#GO:0005622;endoplasmic reticulum protein-containing complex#GO:0140534;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=6267|UniProtKB=P48051 P48051 KCNJ6 PTHR11767:SF19 INWARD RECTIFIER POTASSIUM CHANNEL G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 2 transporter activity#GO:0005215;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261;potassium channel activity#GO:0005267;ligand-gated monoatomic ion channel activity#GO:0015276;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079 cellular process#GO:0009987;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;transport#GO:0006810;establishment of localization#GO:0051234;import into cell#GO:0098657;potassium ion import across plasma membrane#GO:1990573;inorganic cation import across plasma membrane#GO:0098659;import across plasma membrane#GO:0098739;inorganic ion import across plasma membrane#GO:0099587;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GIRK#P00724;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>GIRK#P01083;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GPRK#P00741 HUMAN|HGNC=4186|UniProtKB=P52951 P52951 GBX2 PTHR24334:SF3 HOMEOBOX PROTEIN GBX HOMEOBOX PROTEIN GBX-2 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of multicellular organismal process#GO:0051239;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;regulation of nervous system development#GO:0051960;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of multicellular organismal development#GO:2000026;regulation of developmental process#GO:0050793;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 homeodomain transcription factor#PC00119 HUMAN|HGNC=16992|UniProtKB=Q7L1W4 Q7L1W4 LRRC8D PTHR45752:SF11 LEUCINE-RICH REPEAT-CONTAINING VOLUME-REGULATED ANION CHANNEL SUBUNIT LRRC8D monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;passive transmembrane transporter activity#GO:0022803;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic anion transmembrane transporter activity#GO:0008509;monoatomic anion channel activity#GO:0005253;channel activity#GO:0015267 establishment of localization#GO:0051234;C4-dicarboxylate transport#GO:0015740;transport#GO:0006810;monoatomic ion transmembrane transport#GO:0034220;dicarboxylic acid transport#GO:0006835;biological regulation#GO:0065007;nitrogen compound transport#GO:0071705;aspartate transmembrane transport#GO:0015810;amino acid transmembrane transport#GO:0003333;localization#GO:0051179;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of cellular process#GO:0050794;organophosphate ester transport#GO:0015748;nucleobase-containing compound transport#GO:0015931;carboxylic acid transmembrane transport#GO:1905039;monoatomic anion transport#GO:0006820;carbohydrate derivative transport#GO:1901264;cellular response to stimulus#GO:0051716;import into cell#GO:0098657;amino acid transport#GO:0006865;organic acid transport#GO:0015849;acidic amino acid transport#GO:0015800;carboxylic acid transport#GO:0046942;monoatomic anion transmembrane transport#GO:0098656;cellular process#GO:0009987;signal transduction#GO:0007165;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;import across plasma membrane#GO:0098739;response to stimulus#GO:0050896;signaling#GO:0023052;regulation of biological process#GO:0050789 cell periphery#GO:0071944;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;intracellular anatomical structure#GO:0005622;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351 scaffold/adaptor protein#PC00226 HUMAN|HGNC=857|UniProtKB=P36543 P36543 ATP6V1E1 PTHR45715:SF2 ATPASE H+-TRANSPORTING V1 SUBUNIT E1A-RELATED V-TYPE PROTON ATPASE SUBUNIT E 1 monoatomic cation transmembrane transporter activity#GO:0008324;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;proton transmembrane transporter activity#GO:0015078 monoatomic ion transport#GO:0006811;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;proton transmembrane transport#GO:1902600;transport#GO:0006810;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;cellular process#GO:0009987 proton-transporting two-sector ATPase complex#GO:0016469;vacuolar membrane#GO:0005774;transporter complex#GO:1990351;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;proton-transporting V-type ATPase complex#GO:0033176;membrane#GO:0016020;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;vacuole#GO:0005773;ATPase complex#GO:1904949;vacuolar proton-transporting V-type ATPase complex#GO:0016471;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transmembrane transporter complex#GO:1902495;intracellular anatomical structure#GO:0005622;ATPase dependent transmembrane transport complex#GO:0098533;membrane-bounded organelle#GO:0043227;membrane protein complex#GO:0098796;cation-transporting ATPase complex#GO:0090533;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vacuolar proton-transporting V-type ATPase, V1 domain#GO:0000221;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=20272|UniProtKB=Q8ND23 Q8ND23 CARMIL3 PTHR24112:SF43 LEUCINE-RICH REPEAT, ISOFORM F-RELATED CAPPING PROTEIN, ARP2_3 AND MYOSIN-I LINKER PROTEIN 3 regulation of actin nucleation#GO:0051125;regulation of actin filament-based process#GO:0032970;regulation of biological process#GO:0050789;regulation of supramolecular fiber organization#GO:1902903;cellular process#GO:0009987;regulation of organelle organization#GO:0033043;regulation of actin filament organization#GO:0110053;biological regulation#GO:0065007;regulation of actin cytoskeleton organization#GO:0032956;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;cell motility#GO:0048870;cell migration#GO:0016477;regulation of cellular process#GO:0050794 cell periphery#GO:0071944;cell leading edge#GO:0031252;membrane#GO:0016020;plasma membrane#GO:0005886;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;lamellipodium#GO:0030027;cellular anatomical structure#GO:0110165 protein-binding activity modulator#PC00095 HUMAN|HGNC=24335|UniProtKB=Q99627 Q99627 COPS8 PTHR13339:SF2 COP9 SIGNALOSOME COMPLEX SUBUNIT 8 COP9 SIGNALOSOME COMPLEX SUBUNIT 8 intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;COP9 signalosome#GO:0008180;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 scaffold/adaptor protein#PC00226 HUMAN|HGNC=19989|UniProtKB=Q9UJX6 Q9UJX6 ANAPC2 PTHR45957:SF1 ANAPHASE-PROMOTING COMPLEX SUBUNIT 2 ANAPHASE-PROMOTING COMPLEX SUBUNIT 2 macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein modification by small protein conjugation or removal#GO:0070647;mitotic cell cycle phase transition#GO:0044772;metaphase/anaphase transition of mitotic cell cycle#GO:0007091;cell cycle phase transition#GO:0044770;regulation of cellular process#GO:0050794;mitotic cell cycle#GO:0000278;regulation of cellular component organization#GO:0051128;regulation of sister chromatid segregation#GO:0033045;regulation of cell cycle#GO:0051726;primary metabolic process#GO:0044238;protein modification process#GO:0036211;cell cycle#GO:0007049;protein K11-linked ubiquitination#GO:0070979;regulation of organelle organization#GO:0033043;cell cycle process#GO:0022402;regulation of biological process#GO:0050789;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;macromolecule metabolic process#GO:0043170;mitotic cell cycle process#GO:1903047;regulation of chromosome organization#GO:0033044;metabolic process#GO:0008152;metaphase/anaphase transition of cell cycle#GO:0044784;regulation of chromosome segregation#GO:0051983;post-translational protein modification#GO:0043687;regulation of cell cycle process#GO:0010564;protein ubiquitination#GO:0016567;biological regulation#GO:0065007;cellular process#GO:0009987 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ubiquitin ligase complex#GO:0000151;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear ubiquitin ligase complex#GO:0000152;intracellular membrane-bounded organelle#GO:0043231;cullin-RING ubiquitin ligase complex#GO:0031461;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;nucleus#GO:0005634;protein-containing complex#GO:0032991;anaphase-promoting complex#GO:0005680 Cell cycle#P00013>APC#P00481 HUMAN|HGNC=28618|UniProtKB=Q8N2U0 Q8N2U0 TMEM256 PTHR43461:SF1 TRANSMEMBRANE PROTEIN 256 TRANSMEMBRANE PROTEIN 256 membrane#GO:0016020;cellular anatomical structure#GO:0110165 HUMAN|HGNC=20800|UniProtKB=Q9NTN3 Q9NTN3 SLC35D1 PTHR11132:SF247 SOLUTE CARRIER FAMILY 35 NUCLEOTIDE SUGAR TRANSPORTER SLC35D1 organophosphate ester transmembrane transporter activity#GO:0015605;nucleobase-containing compound transmembrane transporter activity#GO:0015932;carbohydrate derivative transmembrane transporter activity#GO:1901505;nucleotide-sugar transmembrane transporter activity#GO:0005338;carboxylic acid transmembrane transporter activity#GO:0046943;active transmembrane transporter activity#GO:0022804;antiporter activity#GO:0015297;secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 nucleobase-containing compound transport#GO:0015931;organophosphate ester transport#GO:0015748;nucleotide-sugar transmembrane transport#GO:0015780;cellular process#GO:0009987;carbohydrate derivative transport#GO:1901264;nitrogen compound transport#GO:0071705;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;transport#GO:0006810 organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;membrane#GO:0016020 transporter#PC00227;secondary carrier transporter#PC00258 HUMAN|HGNC=17962|UniProtKB=Q96LB2 Q96LB2 MRGPRX1 PTHR11334:SF22 MAS-RELATED G-PROTEIN COUPLED RECEPTOR MAS-RELATED G PROTEIN-COUPLED RECEPTOR MRG-RELATED G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=37231|UniProtKB=B4DS77 B4DS77 SHISA9 PTHR31774:SF1 PROTEIN SHISA-9-RELATED PROTEIN SHISA-9 regulation of biological quality#GO:0065008;regulation of neuronal synaptic plasticity#GO:0048168;regulation of signaling#GO:0023051;regulation of synaptic plasticity#GO:0048167;regulation of cell communication#GO:0010646;modulation of chemical synaptic transmission#GO:0050804;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of trans-synaptic signaling#GO:0099177;regulation of biological process#GO:0050789 cell junction#GO:0030054;transporter complex#GO:1990351;synaptic membrane#GO:0097060;protein-containing complex#GO:0032991;neuron projection#GO:0043005;cell leading edge#GO:0031252;cell projection membrane#GO:0031253;leading edge membrane#GO:0031256;postsynaptic membrane#GO:0045211;cell projection#GO:0042995;neuron spine#GO:0044309;organelle#GO:0043226;cellular anatomical structure#GO:0110165;synapse#GO:0045202;dendritic spine#GO:0043197;postsynapse#GO:0098794;signaling receptor complex#GO:0043235;neuron projection membrane#GO:0032589;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;neuron to neuron synapse#GO:0098984;monoatomic ion channel complex#GO:0034702;cell periphery#GO:0071944;membrane#GO:0016020;transmembrane transporter complex#GO:1902495;dendritic tree#GO:0097447;postsynaptic density#GO:0014069;dendrite#GO:0030425;plasma membrane bounded cell projection#GO:0120025;asymmetric synapse#GO:0032279;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796 HUMAN|HGNC=30208|UniProtKB=Q96RQ1 Q96RQ1 ERGIC2 PTHR10984:SF30 ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 2 transport#GO:0006810;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;establishment of localization#GO:0051234;vesicle-mediated transport#GO:0016192;localization#GO:0051179 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;coated vesicle#GO:0030135;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;COPII-coated ER to Golgi transport vesicle#GO:0030134;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 HUMAN|HGNC=13182|UniProtKB=Q9P1U0 Q9P1U0 POLR1H PTHR11239:SF14 DNA-DIRECTED RNA POLYMERASE DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12 catalytic activity, acting on RNA#GO:0140098;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a nucleic acid#GO:0140640;nucleotidyltransferase activity#GO:0016779;transferase activity, transferring phosphorus-containing groups#GO:0016772 macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;DNA-templated transcription termination#GO:0006353;transcription by RNA polymerase I#GO:0006360;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 transferase complex#GO:1990234;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular organelle#GO:0043229;RNA polymerase I complex#GO:0005736;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 DNA-directed RNA polymerase#PC00019 HUMAN|HGNC=8575|UniProtKB=P68402 P68402 PAFAH1B2 PTHR11852:SF1 PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE IB SUBUNIT ALPHA2 acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity#GO:0016787;transferase activity#GO:0016740;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 multicellular organismal reproductive process#GO:0048609;sexual reproduction#GO:0019953;developmental process#GO:0032502;spermatogenesis#GO:0007283;male gamete generation#GO:0048232;gamete generation#GO:0007276;reproductive process#GO:0022414;developmental process involved in reproduction#GO:0003006 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494 protein modifying enzyme#PC00260 HUMAN|HGNC=10293|UniProtKB=Q96AT9 Q96AT9 RPE PTHR11749:SF18 RIBULOSE-5-PHOSPHATE-3-EPIMERASE RIBULOSE-PHOSPHATE 3-EPIMERASE racemase and epimerase activity, acting on carbohydrates and derivatives#GO:0016857;racemase and epimerase activity#GO:0016854;catalytic activity#GO:0003824;isomerase activity#GO:0016853;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;D-ribulose-phosphate 3-epimerase activity#GO:0004750;metal ion binding#GO:0046872;cation binding#GO:0043169 metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091;nucleobase-containing small molecule metabolic process#GO:0055086;NADP+ metabolic process#GO:0006739;organophosphate metabolic process#GO:0019637;aldehyde metabolic process#GO:0006081;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;nicotinamide nucleotide metabolic process#GO:0046496;nucleobase-containing compound metabolic process#GO:0006139;pentose-phosphate shunt#GO:0006098;NADPH regeneration#GO:0006740;pyridine-containing compound metabolic process#GO:0072524;glyceraldehyde-3-phosphate metabolic process#GO:0019682;nucleotide metabolic process#GO:0009117;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;glucose 6-phosphate metabolic process#GO:0051156;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;pentose-phosphate shunt, non-oxidative branch#GO:0009052;carbohydrate metabolic process#GO:0005975 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 Ascorbate degradation#P02729>L-xylulose-5-phosphate-3-epimerase#P02852 HUMAN|HGNC=27316|UniProtKB=Q6PJ69 Q6PJ69 TRIM65 PTHR25465:SF14 B-BOX DOMAIN CONTAINING E3 UBIQUITIN-PROTEIN LIGASE TRIM65 regulation of metabolic process#GO:0019222;positive regulation of autophagy#GO:0010508;regulation of autophagy#GO:0010506;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;positive regulation of catabolic process#GO:0009896;positive regulation of metabolic process#GO:0009893;regulation of catabolic process#GO:0009894 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=20937|UniProtKB=Q5GH70 Q5GH70 XKR9 PTHR16024:SF13 XK-RELATED PROTEIN XK-RELATED PROTEIN 9 organophosphate ester transport#GO:0015748;lipid translocation#GO:0034204;plasma membrane phospholipid scrambling#GO:0017121;programmed cell death#GO:0012501;cell death#GO:0008219;localization#GO:0051179;anatomical structure development#GO:0048856;lipid transport#GO:0006869;membrane organization#GO:0061024;phospholipid translocation#GO:0045332;phospholipid transport#GO:0015914;biological regulation#GO:0065007;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;regulation of membrane lipid distribution#GO:0097035;phagocytosis#GO:0006909;developmental process#GO:0032502;transport#GO:0006810;endocytosis#GO:0006897;cellular component organization#GO:0016043;execution phase of apoptosis#GO:0097194;apoptotic process#GO:0006915;plasma membrane organization#GO:0007009;regulation of biological quality#GO:0065008;lipid localization#GO:0010876;endomembrane system organization#GO:0010256;cellular process#GO:0009987;phagocytosis, engulfment#GO:0006911;apoptotic cell clearance#GO:0043277;cellular component organization or biogenesis#GO:0071840;import into cell#GO:0098657;membrane invagination#GO:0010324 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 secondary carrier transporter#PC00258 HUMAN|HGNC=21401|UniProtKB=Q96KF7 Q96KF7 SMIM8 PTHR14274:SF1 SMALL INTEGRAL MEMBRANE PROTEIN 8 SMALL INTEGRAL MEMBRANE PROTEIN 8 HUMAN|HGNC=16635|UniProtKB=P82673 P82673 MRPS35 PTHR13490:SF0 MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S28 SMALL RIBOSOMAL SUBUNIT PROTEIN MS35 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 membraneless organelle#GO:0043228;mitochondrial small ribosomal subunit#GO:0005763;membrane-enclosed lumen#GO:0031974;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;small ribosomal subunit#GO:0015935;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;organellar ribosome#GO:0000313;intracellular anatomical structure#GO:0005622;mitochondrial ribosome#GO:0005761;organelle lumen#GO:0043233;mitochondrion#GO:0005739;ribosome#GO:0005840;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 translational protein#PC00263;ribosomal protein#PC00202 HUMAN|HGNC=4702|UniProtKB=P02724 P02724 GYPA PTHR13813:SF3 GLYCOPHORIN GLYCOPHORIN-A cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HUMAN|HGNC=738|UniProtKB=P50553 P50553 ASCL1 PTHR13935:SF66 ACHAETE-SCUTE TRANSCRIPTION FACTOR-RELATED ACHAETE-SCUTE HOMOLOG 1 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of neurogenesis#GO:0050767;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of developmental process#GO:0050793;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biosynthetic process#GO:0009891;regulation of nervous system development#GO:0051960;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;regulation of cell development#GO:0060284;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;sensory organ development#GO:0007423;developmental process#GO:0032502;regulation of cell differentiation#GO:0045595;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;regulation of biological process#GO:0050789;regulation of multicellular organismal development#GO:2000026;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;regulation of multicellular organismal process#GO:0051239;nervous system development#GO:0007399;positive regulation of transcription by RNA polymerase II#GO:0045944;neuron differentiation#GO:0030182;multicellular organism development#GO:0007275;animal organ development#GO:0048513 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264;basic helix-loop-helix transcription factor#PC00055 Gonadotropin-releasing hormone receptor pathway#P06664>MASH1#P06826 HUMAN|HGNC=9122|UniProtKB=P54278 P54278 PMS2 PTHR10073:SF58 DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL MISMATCH REPAIR ENDONUCLEASE PMS2 endonuclease activity#GO:0004519;nuclease activity#GO:0004518;DNA endonuclease activity#GO:0004520;catalytic activity, acting on DNA#GO:0140097;DNA nuclease activity#GO:0004536;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;response to stress#GO:0006950;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;multicellular organismal process#GO:0032501;gene expression#GO:0010467;developmental process#GO:0032502;DNA damage response#GO:0006974;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;macromolecule metabolic process#GO:0043170;multicellular organism development#GO:0007275;mismatch repair#GO:0006298;cellular response to stimulus#GO:0051716;somatic diversification of immune receptors#GO:0002200;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;production of molecular mediator of immune response#GO:0002440;cellular response to stress#GO:0033554;immune system process#GO:0002376;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;immune system development#GO:0002520;anatomical structure development#GO:0048856 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 DNA metabolism protein#PC00009 HUMAN|HGNC=15872|UniProtKB=Q8NHU2 Q8NHU2 CFAP61 PTHR21178:SF8 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 61 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 61 sperm flagellum#GO:0036126;cellular anatomical structure#GO:0110165;organelle#GO:0043226;motile cilium#GO:0031514;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;9+2 motile cilium#GO:0097729;cilium#GO:0005929;membrane-bounded organelle#GO:0043227 structural protein#PC00211 HUMAN|HGNC=1484|UniProtKB=Q9Y6W3 Q9Y6W3 CAPN7 PTHR46143:SF1 CALPAIN-7 CALPAIN-7 hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;endopeptidase activity#GO:0004175;cysteine-type endopeptidase activity#GO:0004197;peptidase activity#GO:0008233;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;proteolysis#GO:0006508;metabolic process#GO:0008152;cellular process#GO:0009987 Huntington disease#P00029>Calpain#P00788 HUMAN|HGNC=180|UniProtKB=P14621 P14621 ACYP2 PTHR10029:SF20 ACYLPHOSPHATASE ACYLPHOSPHATASE-2 hydrolase activity#GO:0016787;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817 phosphatase#PC00181;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=23246|UniProtKB=Q86TC9 Q86TC9 MYPN PTHR10075:SF28 BASIGIN RELATED MYOPALLADIN contractile muscle fiber#GO:0043292;Z disc#GO:0030018;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;supramolecular complex#GO:0099080;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;I band#GO:0031674;intracellular organelle#GO:0043229;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;sarcomere#GO:0030017;myofibril#GO:0030016;membraneless organelle#GO:0043228 cell adhesion molecule#PC00069 HUMAN|HGNC=4591|UniProtKB=Q9NRY4 Q9NRY4 ARHGAP35 PTHR46005:SF1 RHO GTPASE-ACTIVATING PROTEIN 190 RHO GTPASE-ACTIVATING PROTEIN 35 enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772 signal transduction#GO:0007165;regulation of neuron projection development#GO:0010975;cellular process#GO:0009987;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;intracellular signaling cassette#GO:0141124;regulation of anatomical structure size#GO:0090066;regulation of cell projection organization#GO:0031344;regulation of plasma membrane bounded cell projection organization#GO:0120035;cellular component organization or biogenesis#GO:0071840;regulation of anatomical structure morphogenesis#GO:0022603;regulation of axonogenesis#GO:0050770;cellular component organization#GO:0016043;regulation of cellular component size#GO:0032535;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of developmental process#GO:0050793;signaling#GO:0023052;cell communication#GO:0007154;Rho protein signal transduction#GO:0007266;intracellular signal transduction#GO:0035556;regulation of biological quality#GO:0065008;regulation of cell size#GO:0008361 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 G-protein modulator#PC00022;GTPase-activating protein#PC00257 HUMAN|HGNC=20232|UniProtKB=Q8N8G2 Q8N8G2 VGLL2 PTHR15950:SF17 TRANSCRIPTION COFACTOR VESTIGIAL-LIKE PROTEIN TRANSCRIPTION COFACTOR VESTIGIAL-LIKE PROTEIN 2 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 transcription cofactor#PC00217;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=28874|UniProtKB=Q496F6 Q496F6 CD300E PTHR11860:SF89 POLYMERIC-IMMUNOGLOBULIN RECEPTOR CMRF35-LIKE MOLECULE 2 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 response to stimulus#GO:0050896;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of response to biotic stimulus#GO:0002831;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;regulation of immune response#GO:0050776;regulation of defense response#GO:0031347;regulation of response to external stimulus#GO:0032101;biological regulation#GO:0065007;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of innate immune response#GO:0045088;regulation of response to stress#GO:0080134;regulation of response to stimulus#GO:0048583 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=34383|UniProtKB=A6NGG8 A6NGG8 PCARE PTHR22017:SF0 PHOTORECEPTOR CILIUM ACTIN REGULATOR PHOTORECEPTOR CILIUM ACTIN REGULATOR neuron differentiation#GO:0030182;developmental process#GO:0032502;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;intracellular protein localization#GO:0008104;neurogenesis#GO:0022008;macromolecule localization#GO:0033036;cellular process#GO:0009987;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;localization#GO:0051179;anatomical structure development#GO:0048856;system development#GO:0048731;neuron development#GO:0048666;cellular component organization#GO:0016043;cell differentiation#GO:0030154;protein localization to organelle#GO:0033365;protein localization to cilium#GO:0061512;cell development#GO:0048468 9+0 non-motile cilium#GO:0097731;neuron projection#GO:0043005;photoreceptor cell cilium#GO:0097733;organelle#GO:0043226;photoreceptor outer segment#GO:0001750;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;photoreceptor inner segment#GO:0001917;cilium#GO:0005929;membrane-bounded organelle#GO:0043227;non-motile cilium#GO:0097730 HUMAN|HGNC=13178|UniProtKB=Q9UKT9 Q9UKT9 IKZF3 PTHR24404:SF23 ZINC FINGER PROTEIN ZINC FINGER PROTEIN AIOLOS sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218 HUMAN|HGNC=12139|UniProtKB=A0A0B4J263 A0A0B4J263 TRAV39 PTHR19433:SF85 T-CELL RECEPTOR ALPHA CHAIN V REGION-RELATED T CELL RECEPTOR ALPHA VARIABLE 17-RELATED response to bacterium#GO:0009617;response to biotic stimulus#GO:0009607;response to other organism#GO:0051707;response to external stimulus#GO:0009605;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=21420|UniProtKB=Q8IZL9 Q8IZL9 CDK20 PTHR24056:SF600 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE 20 protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=18308|UniProtKB=Q9NVH6 Q9NVH6 TMLHE PTHR10696:SF51 GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED TRIMETHYLLYSINE DIOXYGENASE, MITOCHONDRIAL 2-oxoglutarate-dependent dioxygenase activity#GO:0016706;oxidoreductase activity#GO:0016491;dioxygenase activity#GO:0051213;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705 carnitine metabolic process#GO:0009437;cellular process#GO:0009987;metabolic process#GO:0008152;modified amino acid metabolic process#GO:0006575;biosynthetic process#GO:0009058 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 metabolite interconversion enzyme#PC00262;hydroxylase#PC00122 HUMAN|HGNC=11354|UniProtKB=Q8WVM7 Q8WVM7 STAG1 PTHR11199:SF6 STROMAL ANTIGEN COHESIN SUBUNIT SA-1 chromatin binding#GO:0003682;binding#GO:0005488 chromosome organization#GO:0051276;sister chromatid cohesion#GO:0007062;cellular component organization or biogenesis#GO:0071840;cell cycle process#GO:0022402;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;cell cycle#GO:0007049 intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cohesin complex#GO:0008278;organelle#GO:0043226;nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=11121|UniProtKB=O60906 O60906 SMPD2 PTHR12393:SF8 SPHINGOMYELIN PHOSPHODIESTERASE RELATED SPHINGOMYELIN PHOSPHODIESTERASE 2 catalytic activity#GO:0003824;lipase activity#GO:0016298;phospholipase activity#GO:0120569;hydrolase activity, acting on ester bonds#GO:0016788;phosphoric diester hydrolase activity#GO:0008081;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578 cellular process#GO:0009987;lipid catabolic process#GO:0016042;organophosphate metabolic process#GO:0019637;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;sphingomyelin metabolic process#GO:0006684;lipid metabolic process#GO:0006629;ceramide biosynthetic process#GO:0046513;sphingolipid biosynthetic process#GO:0030148;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;sphingolipid catabolic process#GO:0030149;phospholipid metabolic process#GO:0006644;catabolic process#GO:0009056;ceramide metabolic process#GO:0006672 membrane microdomain#GO:0098857;endoplasmic reticulum#GO:0005783;membrane#GO:0016020;caveola#GO:0005901;cell periphery#GO:0071944;plasma membrane region#GO:0098590;endomembrane system#GO:0012505;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;plasma membrane raft#GO:0044853;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane raft#GO:0045121;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 phosphodiesterase#PC00185 HUMAN|HGNC=5117|UniProtKB=P17509 P17509 HOXB6 PTHR45659:SF9 HOMEOBOX PROTEIN HOX HOMEOBOX PROTEIN HOX-B6 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;regionalization#GO:0003002;developmental process#GO:0032502;anterior/posterior pattern specification#GO:0009952;regulation of gene expression#GO:0010468;multicellular organism development#GO:0007275;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;pattern specification process#GO:0007389;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 HUMAN|HGNC=17422|UniProtKB=Q9NPF2 Q9NPF2 CHST11 PTHR12137:SF32 CARBOHYDRATE SULFOTRANSFERASE CARBOHYDRATE SULFOTRANSFERASE 11 catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring sulphur-containing groups#GO:0016782;sulfotransferase activity#GO:0008146 proteoglycan metabolic process#GO:0006029;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;biosynthetic process#GO:0009058;proteoglycan biosynthetic process#GO:0030166;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101 transferase#PC00220 HUMAN|HGNC=10701|UniProtKB=Q15436 Q15436 SEC23A PTHR11141:SF7 PROTEIN TRANSPORT PROTEIN SEC23 PROTEIN TRANSPORT PROTEIN SEC23A enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772 cellular component organization#GO:0016043;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;localization#GO:0051179;cellular localization#GO:0051641;COPII-coated vesicle budding#GO:0090114;membrane organization#GO:0061024;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle organization#GO:0006996;vesicle organization#GO:0016050;vesicle budding from membrane#GO:0006900;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;transport#GO:0006810;Golgi vesicle transport#GO:0048193;intracellular transport#GO:0046907 intracellular organelle#GO:0043229;coated membrane#GO:0048475;COPII-coated ER to Golgi transport vesicle#GO:0030134;membrane coat#GO:0030117;membrane-bounded organelle#GO:0043227;coated vesicle#GO:0030135;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;coated vesicle membrane#GO:0030662;intracellular membrane-bounded organelle#GO:0043231;ER to Golgi transport vesicle membrane#GO:0012507;endoplasmic reticulum#GO:0005783;endoplasmic reticulum exit site#GO:0070971;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;vesicle membrane#GO:0012506;membrane#GO:0016020;transport vesicle#GO:0030133;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;transport vesicle membrane#GO:0030658;vesicle coat#GO:0030120;cytoplasm#GO:0005737 vesicle coat protein#PC00235;membrane traffic protein#PC00150 HUMAN|HGNC=7173|UniProtKB=P08254 P08254 MMP3 PTHR10201:SF215 MATRIX METALLOPROTEINASE STROMELYSIN-1 catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;extracellular structure organization#GO:0043062;metabolic process#GO:0008152;catabolic process#GO:0009056;cellular process#GO:0009987;cellular component organization#GO:0016043 metalloprotease#PC00153 CCKR signaling map#P06959>MMP3#P07105;Plasminogen activating cascade#P00050>pro-MMP-3#P01260;Plasminogen activating cascade#P00050>MMP-3#P01251 HUMAN|HGNC=11201|UniProtKB=P35711 P35711 SOX5 PTHR45789:SF3 FI18025P1 TRANSCRIPTION FACTOR SOX-5 double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of multicellular organismal process#GO:0051239;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of cell differentiation#GO:0045597;regulation of cell differentiation#GO:0045595;positive regulation of developmental process#GO:0051094;developmental process#GO:0032502;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of multicellular organismal development#GO:2000026;positive regulation of multicellular organismal process#GO:0051240;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of developmental process#GO:0050793;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;cell fate commitment#GO:0045165 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 HUMAN|Ensembl=ENSG00000277856.1|UniProtKB=A0AAG2SXZ4 A0AAG2SXZ4 PTHR23266:SF236 IMMUNOGLOBULIN HEAVY CHAIN IG-LIKE DOMAIN-CONTAINING PROTEIN-RELATED antigen binding#GO:0003823;binding#GO:0005488 immune response#GO:0006955;response to stimulus#GO:0050896;adaptive immune response#GO:0002250;immune system process#GO:0002376;immune effector process#GO:0002252;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449;immunoglobulin mediated immune response#GO:0016064;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=29645|UniProtKB=Q9NXK6 Q9NXK6 PAQR5 PTHR20855:SF38 ADIPOR/PROGESTIN RECEPTOR-RELATED MEMBRANE PROGESTIN RECEPTOR GAMMA signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=37286|UniProtKB=A6NGH7 A6NGH7 CCDC160 PTHR48251:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 160 COILED-COIL DOMAIN-CONTAINING PROTEIN 160 HUMAN|HGNC=7329|UniProtKB=P52701 P52701 MSH6 PTHR11361:SF148 DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER DNA MISMATCH REPAIR PROTEIN MSH6 binding#GO:0005488;nucleic acid binding#GO:0003676;ATP-dependent activity#GO:0140657;DNA binding#GO:0003677;ATP-dependent activity, acting on DNA#GO:0008094;double-stranded DNA binding#GO:0003690;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on DNA#GO:0140097;molecular sensor activity#GO:0140299;molecular function regulator activity#GO:0098772 metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;response to stress#GO:0006950;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mismatch repair#GO:0006298;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139 intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 DNA metabolism protein#PC00009 HUMAN|HGNC=37099|UniProtKB=A6NKF7 A6NKF7 TMEM278 PTHR28628:SF2 TRANSMEMBRANE PROTEIN 88-RELATED TRANSMEMBRANE PROTEIN 278 negative regulation of response to stimulus#GO:0048585;negative regulation of Wnt signaling pathway#GO:0030178;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of canonical Wnt signaling pathway#GO:0060828;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of cell communication#GO:0010648;negative regulation of canonical Wnt signaling pathway#GO:0090090;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HUMAN|HGNC=23041|UniProtKB=Q86YH6 Q86YH6 PDSS2 PTHR12001:SF55 GERANYLGERANYL PYROPHOSPHATE SYNTHASE ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS2 transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;prenyltransferase activity#GO:0004659;transferase activity#GO:0016740;catalytic activity#GO:0003824 small molecule biosynthetic process#GO:0044283;isoprenoid biosynthetic process#GO:0008299;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;isoprenoid metabolic process#GO:0006720;ubiquinone biosynthetic process#GO:0006744;cellular process#GO:0009987;ketone biosynthetic process#GO:0042181;primary metabolic process#GO:0044238;ketone metabolic process#GO:0042180;biosynthetic process#GO:0009058;small molecule metabolic process#GO:0044281;lipid biosynthetic process#GO:0008610 mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 metabolite interconversion enzyme#PC00262 HUMAN|HGNC=12373|UniProtKB=P16473 P16473 TSHR PTHR24372:SF0 GLYCOPROTEIN HORMONE RECEPTOR THYROTROPIN RECEPTOR G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528 response to chemical#GO:0042221;biological regulation#GO:0065007;response to hormone#GO:0009725;cellular process#GO:0009987;signal transduction#GO:0007165;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;regulation of cellular process#GO:0050794;cellular response to hormone stimulus#GO:0032870;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;signaling#GO:0023052;response to endogenous stimulus#GO:0009719;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;hormone-mediated signaling pathway#GO:0009755;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021 HUMAN|HGNC=14931|UniProtKB=Q9NTG7 Q9NTG7 SIRT3 PTHR11085:SF5 NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-3, MITOCHONDRIAL catalytic activity, acting on a protein#GO:0140096;NAD-dependent protein lysine deacetylase activity#GO:0034979;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;histone deacetylase activity#GO:0004407;transferase activity#GO:0016740;catalytic activity#GO:0003824;deacylase activity#GO:0160215;deacetylase activity#GO:0019213;histone modifying activity#GO:0140993;acyltransferase activity#GO:0016746 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=4666|UniProtKB=Q9Y5Q9 Q9Y5Q9 GTF3C3 PTHR23082:SF0 TRANSCRIPTION INITIATION FACTOR IIIC TFIIIC , POLYPEPTIDE 3-RELATED GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 3 nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;transcription by RNA polymerase III#GO:0006383;transcription initiation at RNA polymerase III promoter#GO:0006384;DNA-templated transcription initiation#GO:0006352;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058 transcription factor TFIIIC complex#GO:0000127;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 RNA metabolism protein#PC00031;general transcription factor#PC00259 HUMAN|HGNC=16460|UniProtKB=O94887 O94887 FARP2 PTHR45858:SF4 FERM DOMAIN CONTAINING PROTEIN FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 2 molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;guanyl-nucleotide exchange factor activity#GO:0005085 HUMAN|HGNC=26010|UniProtKB=Q96EA4 Q96EA4 SPDL1 PTHR32123:SF9 BICD FAMILY-LIKE CARGO ADAPTER PROTEIN SPINDLY binding#GO:0005488 cell cycle#GO:0007049;microtubule cytoskeleton organization involved in mitosis#GO:1902850;establishment of cell polarity#GO:0030010;mitotic metaphase chromosome alignment#GO:0007080;mitotic cell cycle#GO:0000278;protein localization to organelle#GO:0033365;organelle localization#GO:0051640;localization#GO:0051179;microtubule cytoskeleton organization#GO:0000226;organelle fission#GO:0048285;macromolecule localization#GO:0033036;mitotic sister chromatid segregation#GO:0000070;protein localization to kinetochore#GO:0034501;establishment of spindle localization#GO:0051293;establishment of mitotic spindle orientation#GO:0000132;establishment of localization#GO:0051234;mitotic cell cycle process#GO:1903047;intracellular protein localization#GO:0008104;chromosome organization#GO:0051276;nuclear chromosome segregation#GO:0098813;cellular component organization#GO:0016043;sister chromatid segregation#GO:0000819;mitotic nuclear division#GO:0140014;cell cycle process#GO:0022402;establishment of organelle localization#GO:0051656;establishment or maintenance of cell polarity#GO:0007163;nuclear division#GO:0000280;cellular localization#GO:0051641;spindle localization#GO:0051653;organelle organization#GO:0006996;establishment of mitotic spindle localization#GO:0040001;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;cytoskeleton organization#GO:0007010;chromosome localization#GO:0050000;metaphase chromosome alignment#GO:0051310;chromosome segregation#GO:0007059;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;establishment of spindle orientation#GO:0051294 spindle#GO:0005819;cytoskeleton#GO:0005856;condensed chromosome#GO:0000793;chromosome, centromeric region#GO:0000775;outer kinetochore#GO:0000940;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;condensed chromosome, centromeric region#GO:0000779;intracellular membraneless organelle#GO:0043232;supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687;kinetochore#GO:0000776;spindle pole#GO:0000922;chromosome#GO:0005694;organelle#GO:0043226;cellular anatomical structure#GO:0110165 membrane trafficking regulatory protein#PC00151;membrane traffic protein#PC00150 HUMAN|HGNC=21385|UniProtKB=Q9UIY3 Q9UIY3 RWDD2A PTHR15955:SF3 RWD DOMAIN CONTAINING PROTEIN 2 RWD DOMAIN-CONTAINING PROTEIN 2A ubiquitin-protein ligase#PC00234 HUMAN|HGNC=11895|UniProtKB=Q03169 Q03169 TNFAIP2 PTHR21292:SF4 EXOCYST COMPLEX COMPONENT SEC6-RELATED TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 2 binding#GO:0005488;SNARE binding#GO:0000149;protein binding#GO:0005515 exocytosis#GO:0006887;secretion by cell#GO:0032940;localization#GO:0051179;establishment of localization#GO:0051234;secretion#GO:0046903;transport#GO:0006810;export from cell#GO:0140352;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;exocyst#GO:0000145;cell cortex#GO:0005938;cell periphery#GO:0071944;vesicle tethering complex#GO:0099023;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HUMAN|HGNC=51259|UniProtKB=H7C241 H7C241 CLDN34 PTHR12002:SF4 CLAUDIN CLAUDIN-34 cellular component organization or biogenesis#GO:0071840;cell-cell junction assembly#GO:0007043;cell-cell junction organization#GO:0045216;cell junction organization#GO:0034330;cellular component assembly#GO:0022607;cellular component organization#GO:0016043;cell junction assembly#GO:0034329;cellular component biogenesis#GO:0044085;cellular process#GO:0009987 anchoring junction#GO:0070161;cell junction#GO:0030054;tight junction#GO:0070160;apical junction complex#GO:0043296;plasma membrane#GO:0005886;bicellular tight junction#GO:0005923;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;cell-cell junction#GO:0005911 tight junction#PC00214;cell junction protein#PC00070 HUMAN|HGNC=23622|UniProtKB=Q8TDT2 Q8TDT2 GPR152 PTHR11334:SF1 MAS-RELATED G-PROTEIN COUPLED RECEPTOR G PROTEIN-COUPLED RECEPTOR 152-RELATED signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=1055|UniProtKB=P62952 P62952 BLCAP PTHR13259:SF1 BLADDER CANCER 10 KD PROTEIN HOMOLOG APOPTOSIS INDUCING FACTOR BLCAP HUMAN|HGNC=25302|UniProtKB=O75208 O75208 COQ9 PTHR21427:SF19 UBIQUINONE BIOSYNTHESIS PROTEIN COQ9, MITOCHONDRIAL UBIQUINONE BIOSYNTHESIS PROTEIN COQ9, MITOCHONDRIAL lipid binding#GO:0008289;binding#GO:0005488 biosynthetic process#GO:0009058;small molecule metabolic process#GO:0044281;cellular process#GO:0009987;ketone biosynthetic process#GO:0042181;ubiquinone biosynthetic process#GO:0006744;ketone metabolic process#GO:0042180;small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;mitochondrial inner membrane#GO:0005743;organelle envelope#GO:0031967;membrane#GO:0016020;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=7559|UniProtKB=P04198 P04198 MYCN PTHR45851:SF2 MYC PROTO-ONCOGENE N-MYC PROTO-ONCOGENE PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 basic helix-loop-helix transcription factor#PC00055;DNA-binding transcription factor#PC00218 Wnt signaling pathway#P00057>Wnt Target Genes#G01558 HUMAN|HGNC=26517|UniProtKB=Q96MD2 Q96MD2 KICS2 PTHR31581:SF1 KICSTOR COMPLEX PROTEIN C12ORF66 KICSTOR SUBUNIT 2 protein localization to lysosome#GO:0061462;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;cellular response to stress#GO:0033554;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;response to stress#GO:0006950;regulation of TOR signaling#GO:0032006;cellular process#GO:0009987;cellular response to amino acid starvation#GO:0034198;negative regulation of signal transduction#GO:0009968;negative regulation of TORC1 signaling#GO:1904262;response to starvation#GO:0042594;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;protein localization to organelle#GO:0033365;negative regulation of TOR signaling#GO:0032007;regulation of cell communication#GO:0010646;protein localization to vacuole#GO:0072665;localization#GO:0051179;macromolecule localization#GO:0033036;response to nutrient levels#GO:0031667;negative regulation of response to stimulus#GO:0048585;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;cellular response to starvation#GO:0009267;regulation of response to stimulus#GO:0048583;cellular response to nutrient levels#GO:0031669;regulation of TORC1 signaling#GO:1903432;intracellular protein localization#GO:0008104 protein-containing complex#GO:0032991 HUMAN|HGNC=11512|UniProtKB=Q9H2B2 Q9H2B2 SYT4 PTHR10024:SF114 SYNAPTOTAGMIN SYNAPTOTAGMIN-4 SNARE binding#GO:0000149;binding#GO:0005488;phospholipid binding#GO:0005543;protein binding#GO:0005515;molecular function regulator activity#GO:0098772;lipid binding#GO:0008289;molecular sensor activity#GO:0140299 vesicle-mediated transport#GO:0016192;organelle fusion#GO:0048284;organelle membrane fusion#GO:0090174;neurotransmitter transport#GO:0006836;synaptic signaling#GO:0099536;organelle organization#GO:0006996;cellular process#GO:0009987;synaptic vesicle exocytosis#GO:0016079;establishment of localization in cell#GO:0051649;positive regulation of transport#GO:0051050;positive regulation of biological process#GO:0048518;vesicle-mediated transport in synapse#GO:0099003;cellular component organization or biogenesis#GO:0071840;vesicle organization#GO:0016050;regulation of transport#GO:0051049;exocytosis#GO:0006887;positive regulation of vesicle fusion#GO:0031340;regulation of localization#GO:0032879;regulated exocytosis#GO:0045055;regulation of cellular component organization#GO:0051128;signaling#GO:0023052;export from cell#GO:0140352;cellular component organization#GO:0016043;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;positive regulation of organelle organization#GO:0010638;cellular localization#GO:0051641;regulation of secretion by cell#GO:1903530;secretion by cell#GO:0032940;positive regulation of cellular component organization#GO:0051130;neurotransmitter secretion#GO:0007269;membrane organization#GO:0061024;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;membrane fusion#GO:0061025;positive regulation of cellular process#GO:0048522;establishment of localization#GO:0051234;synaptic vesicle cycle#GO:0099504;transport#GO:0006810;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;vesicle fusion#GO:0006906;signal release from synapse#GO:0099643;chemical synaptic transmission#GO:0007268;secretion#GO:0046903;localization#GO:0051179;cell communication#GO:0007154;regulation of secretion#GO:0051046;regulation of exocytosis#GO:0017157;trans-synaptic signaling#GO:0099537;signal release#GO:0023061 neuron projection#GO:0043005;cell periphery#GO:0071944;secretory vesicle#GO:0099503;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;transport vesicle#GO:0030133;endomembrane system#GO:0012505;cell junction#GO:0030054;vesicle#GO:0031982;intracellular vesicle#GO:0097708;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;synapse#GO:0045202;axon#GO:0030424;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410 membrane trafficking regulatory protein#PC00151 Gonadotropin-releasing hormone receptor pathway#P06664>Syt IV#P06746 HUMAN|HGNC=24324|UniProtKB=Q8WX92 Q8WX92 NELFB PTHR13503:SF3 NEGATIVE ELONGATION FACTOR COMPLEX MEMBER B NEGATIVE ELONGATION FACTOR B regulation of transcription elongation by RNA polymerase II#GO:0034243;regulation of DNA-templated transcription elongation#GO:0032784;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;developmental process#GO:0032502;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;stem cell differentiation#GO:0048863;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219 nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;transcription elongation factor complex#GO:0008023;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 HUMAN|HGNC=23843|UniProtKB=Q96IK5 Q96IK5 GMCL1 PTHR23231:SF19 GERM CELL-LESS PROTEIN GERM CELL-LESS PROTEIN-LIKE 1 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=25793|UniProtKB=Q8IZ21 Q8IZ21 PHACTR4 PTHR12751:SF4 PHOSPHATASE AND ACTIN REGULATOR PHACTR PHOSPHATASE AND ACTIN REGULATOR 4 protein binding#GO:0005515;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779 cellular process#GO:0009987;neural crest cell migration#GO:0001755;organelle organization#GO:0006996;stem cell differentiation#GO:0048863;cytoskeleton organization#GO:0007010;cell migration#GO:0016477;tissue development#GO:0009888;neural crest cell development#GO:0014032;developmental process#GO:0032502;neural crest cell differentiation#GO:0014033;mesenchymal cell differentiation#GO:0048762;mesenchyme development#GO:0060485;cellular component organization or biogenesis#GO:0071840;animal organ development#GO:0048513;cellular developmental process#GO:0048869;cellular component organization#GO:0016043;cell development#GO:0048468;cell differentiation#GO:0030154;cell motility#GO:0048870;actin cytoskeleton organization#GO:0030036;actin filament-based process#GO:0030029;stem cell development#GO:0048864;animal gross anatomical part developmental process#GO:0160108;anatomical structure development#GO:0048856 phosphatase modulator#PC00184 HUMAN|HGNC=26149|UniProtKB=Q53LP3 Q53LP3 SOWAHC PTHR14491:SF4 SOSONDOWAH, ISOFORM G ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN SOWAHC HUMAN|HGNC=1925|UniProtKB=O14757 O14757 CHEK1 PTHR24343:SF540 SERINE/THREONINE KINASE SERINE_THREONINE-PROTEIN KINASE CHK1 catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;histone kinase activity#GO:0035173;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;histone modifying activity#GO:0140993;protein kinase activity#GO:0004672 negative regulation of cell cycle#GO:0045786;negative regulation of cell cycle G2/M phase transition#GO:1902750;negative regulation of G2/M transition of mitotic cell cycle#GO:0010972;negative regulation of mitotic cell cycle phase transition#GO:1901991;cell cycle checkpoint signaling#GO:0000075;regulation of cell cycle process#GO:0010564;response to stress#GO:0006950;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of mitotic cell cycle phase transition#GO:1901990;mitotic G2 DNA damage checkpoint signaling#GO:0007095;negative regulation of mitotic cell cycle#GO:0045930;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;signaling#GO:0023052;regulation of cell cycle#GO:0051726;negative regulation of cell cycle phase transition#GO:1901988;negative regulation of biological process#GO:0048519;cell cycle process#GO:0022402;regulation of biological process#GO:0050789;signal transduction in response to DNA damage#GO:0042770;mitotic cell cycle process#GO:1903047;negative regulation of cellular process#GO:0048523;negative regulation of cell cycle process#GO:0010948;DNA damage response#GO:0006974;DNA damage checkpoint signaling#GO:0000077;biological regulation#GO:0065007;DNA integrity checkpoint signaling#GO:0031570;regulation of cell cycle G2/M phase transition#GO:1902749;regulation of mitotic cell cycle#GO:0007346;mitotic DNA integrity checkpoint signaling#GO:0044774;mitotic G2/M transition checkpoint#GO:0044818;regulation of G2/M transition of mitotic cell cycle#GO:0010389;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of cellular process#GO:0050794;mitotic cell cycle#GO:0000278;regulation of cell cycle phase transition#GO:1901987;cell cycle#GO:0007049;mitotic cell cycle checkpoint signaling#GO:0007093;mitotic DNA damage checkpoint signaling#GO:0044773;cellular response to stimulus#GO:0051716 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=11586|UniProtKB=Q9Y4P3 Q9Y4P3 TBL2 PTHR44321:SF1 TRANSDUCIN BETA-LIKE PROTEIN 2 TRANSDUCIN BETA-LIKE PROTEIN 2 cellular process#GO:0009987;signal transduction#GO:0007165;endoplasmic reticulum unfolded protein response#GO:0030968;response to stress#GO:0006950;biological regulation#GO:0065007;cellular response to topologically incorrect protein#GO:0035967;cellular response to stress#GO:0033554;cellular response to unfolded protein#GO:0034620;response to endoplasmic reticulum stress#GO:0034976;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;response to unfolded protein#GO:0006986;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signaling#GO:0023052;response to topologically incorrect protein#GO:0035966;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 HUMAN|HGNC=28417|UniProtKB=Q9BTE6 Q9BTE6 AARSD1 PTHR43462:SF1 ALANYL-TRNA EDITING PROTEIN ALANYL-TRNA EDITING PROTEIN AARSD1 carboxylic ester hydrolase activity#GO:0052689;hydrolase activity#GO:0016787;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity#GO:0003824;deacylase activity#GO:0160215;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on RNA#GO:0140098 biological regulation#GO:0065007;regulation of biological quality#GO:0065008 RNA metabolism protein#PC00031 HUMAN|HGNC=620|UniProtKB=P05067 P05067 APP PTHR23103:SF7 ALZHEIMER'S DISEASE BETA-AMYLOID RELATED AMYLOID-BETA PRECURSOR PROTEIN protein binding#GO:0005515;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;signaling receptor binding#GO:0005102;binding#GO:0005488;signaling receptor regulator activity#GO:0030545 neuron differentiation#GO:0030182;developmental process#GO:0032502;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron projection morphogenesis#GO:0048812;cell projection morphogenesis#GO:0048858;neurogenesis#GO:0022008;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;cellular process#GO:0009987;neuron projection development#GO:0031175;axon development#GO:0061564;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cell morphogenesis involved in neuron differentiation#GO:0048667;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;neuron development#GO:0048666;axonogenesis#GO:0007409;anatomical structure development#GO:0048856;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;cell development#GO:0048468;cell differentiation#GO:0030154;cell projection organization#GO:0030030;central nervous system development#GO:0007417;cell morphogenesis#GO:0000902 endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;early endosome#GO:0005769;vesicle#GO:0031982;membrane raft#GO:0045121;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;membrane microdomain#GO:0098857;Golgi apparatus#GO:0005794;cell periphery#GO:0071944;membrane#GO:0016020;cytoplasm#GO:0005737;plasma membrane#GO:0005886;endomembrane system#GO:0012505;cell surface#GO:0009986 protease inhibitor#PC00191 Blood coagulation#P00011>PN2#P00429;Alzheimer disease-amyloid secretase pathway#P00003>C83#P00100;Alzheimer disease-amyloid secretase pathway#P00003>APPalpha#P00097;Alzheimer disease-amyloid secretase pathway#P00003>APP#P00085;Alzheimer disease-amyloid secretase pathway#P00003>p3#P00086;Alzheimer disease-amyloid secretase pathway#P00003>C99#P00106;Alzheimer disease-presenilin pathway#P00004>APP#P00127;Alzheimer disease-presenilin pathway#P00004>C99#P00111;Alzheimer disease-presenilin pathway#P00004>APPbeta#P00151;Alzheimer disease-amyloid secretase pathway#P00003>AICD#P00080;Alzheimer disease-presenilin pathway#P00004>AICD#P00166;Alzheimer disease-presenilin pathway#P00004>Abeta#P00136;Alzheimer disease-amyloid secretase pathway#P00003>Abeta#P00096;Alzheimer disease-amyloid secretase pathway#P00003>APPbeta#P00104 HUMAN|HGNC=39051|UniProtKB=B6SEH9 B6SEH9 ERVV-2 PTHR10424:SF74 VIRAL ENVELOPE PROTEIN ENDOGENOUS RETROVIRUS GROUP V MEMBER 2 ENV POLYPROTEIN cellular developmental process#GO:0048869;anatomical structure development#GO:0048856;syncytium formation by cell-cell fusion#GO:0000768;striated muscle cell differentiation#GO:0051146;animal gross anatomical part developmental process#GO:0160108;cell-cell fusion#GO:0140253;developmental process#GO:0032502;muscle structure development#GO:0061061;cell differentiation#GO:0030154;myoblast fusion#GO:0007520;cellular process#GO:0009987;muscle cell differentiation#GO:0042692 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 viral or transposable element protein#PC00237 HUMAN|HGNC=32414|UniProtKB=P0DJD0 P0DJD0 RGPD1 PTHR23138:SF168 RAN BINDING PROTEIN RANBP2-LIKE AND GRIP DOMAIN-CONTAINING PROTEIN 1-RELATED catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746;SUMO transferase activity#GO:0019789;ubiquitin-like protein transferase activity#GO:0019787 cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;protein localization to nucleus#GO:0034504;macromolecule localization#GO:0033036;import into nucleus#GO:0051170;intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;protein localization to organelle#GO:0033365;nucleocytoplasmic transport#GO:0006913;nuclear export#GO:0051168;protein import into nucleus#GO:0006606;protein transport#GO:0015031;nuclear transport#GO:0051169;cellular localization#GO:0051641;NLS-bearing protein import into nucleus#GO:0006607;localization#GO:0051179 organelle envelope#GO:0031967;nucleus#GO:0005634;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;nuclear pore#GO:0005643;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HUMAN|HGNC=23166|UniProtKB=Q8TCS8 Q8TCS8 PNPT1 PTHR11252:SF9 POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE 1, MITOCHONDRIAL catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a nucleic acid#GO:0140640;nucleotidyltransferase activity#GO:0016779;hydrolase activity, acting on ester bonds#GO:0016788;transferase activity, transferring phosphorus-containing groups#GO:0016772;3'-5' exonuclease activity#GO:0008408;catalytic activity, acting on RNA#GO:0140098;RNA nuclease activity#GO:0004540;exonuclease activity#GO:0004527;3'-5'-RNA exonuclease activity#GO:0000175;hydrolase activity#GO:0016787;nuclease activity#GO:0004518 macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;biological regulation#GO:0065007;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;mitochondrial RNA processing#GO:0000963;nucleic acid catabolic process#GO:0141188;macromolecule biosynthetic process#GO:0009059;mitochondrial RNA metabolic process#GO:0000959;mitochondrial gene expression#GO:0140053;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA 3'-end processing#GO:0031123;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;nucleobase-containing compound biosynthetic process#GO:0034654;gene expression#GO:0010467;RNA processing#GO:0006396;mitochondrial RNA 3'-end processing#GO:0000965;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;cellular process#GO:0009987;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA catabolic process#GO:0006401;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;cytosol#GO:0005829 nucleotidyltransferase#PC00174 HUMAN|HGNC=20360|UniProtKB=Q96NI6 Q96NI6 LRFN5 PTHR45842:SF10 SYNAPTIC ADHESION-LIKE MOLECULE SALM LEUCINE-RICH REPEAT AND FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN 5 biological regulation#GO:0065007;regulation of synapse assembly#GO:0051963;cellular process#GO:0009987;cell-cell adhesion#GO:0098609;cellular component organization or biogenesis#GO:0071840;regulation of cellular component biogenesis#GO:0044087;regulation of cellular process#GO:0050794;cell junction organization#GO:0034330;regulation of cellular component organization#GO:0051128;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;regulation of biological quality#GO:0065008;synaptic membrane adhesion#GO:0099560;regulation of synapse structure or activity#GO:0050803;regulation of synapse organization#GO:0050807;regulation of cell junction assembly#GO:1901888;cell adhesion#GO:0007155;synapse organization#GO:0050808 synaptic membrane#GO:0097060;cell junction#GO:0030054;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;glutamatergic synapse#GO:0098978;neuron to neuron synapse#GO:0098984;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;cell surface#GO:0009986;postsynaptic density#GO:0014069;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;postsynaptic density membrane#GO:0098839;postsynapse#GO:0098794;GABA-ergic synapse#GO:0098982;synapse#GO:0045202;cellular anatomical structure#GO:0110165;asymmetric synapse#GO:0032279;organelle#GO:0043226 immunoglobulin superfamily cell adhesion molecule#PC00125;cell adhesion molecule#PC00069 HUMAN|HGNC=453|UniProtKB=P02760 P02760 AMBP PTHR46676:SF1 PROTEIN AMBP PROTEIN AMBP enzyme regulator activity#GO:0030234;serine-type endopeptidase inhibitor activity#GO:0004867;molecular function inhibitor activity#GO:0140678;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;peptidase regulator activity#GO:0061134;endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772;enzyme inhibitor activity#GO:0004857 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cell surface#GO:0009986;cellular anatomical structure#GO:0110165 HUMAN|HGNC=16855|UniProtKB=Q15035 Q15035 TRAM2 PTHR12371:SF4 TRANSLOCATION ASSOCIATED MEMBRANE PROTEIN TRANSLOCATING CHAIN-ASSOCIATED MEMBRANE PROTEIN 2 membrane organization#GO:0061024;endomembrane system organization#GO:0010256;protein insertion into membrane#GO:0051205;cellular process#GO:0009987;establishment of protein localization#GO:0045184;macromolecule localization#GO:0033036;establishment of protein localization to membrane#GO:0090150;organelle organization#GO:0006996;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;protein localization to organelle#GO:0033365;protein insertion into ER membrane#GO:0045048;endoplasmic reticulum organization#GO:0007029;cellular component organization#GO:0016043;cellular localization#GO:0051641;localization#GO:0051179;localization within membrane#GO:0051668 membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984 HUMAN|HGNC=2397|UniProtKB=P53674 P53674 CRYBB1 PTHR11818:SF12 BETA/GAMMA CRYSTALLIN BETA-CRYSTALLIN B1 structural molecule activity#GO:0005198 system process#GO:0003008;multicellular organism development#GO:0007275;animal organ development#GO:0048513;developmental process#GO:0032502;lens development in camera-type eye#GO:0002088;sensory organ development#GO:0007423;multicellular organismal process#GO:0032501;sensory system development#GO:0048880;system development#GO:0048731;eye development#GO:0001654;anatomical structure development#GO:0048856;sensory perception#GO:0007600;nervous system process#GO:0050877;camera-type eye development#GO:0043010;animal gross anatomical part developmental process#GO:0160108;visual system development#GO:0150063;visual perception#GO:0007601;sensory perception of light stimulus#GO:0050953 structural protein#PC00211 HUMAN|HGNC=31266|UniProtKB=Q6IF82 Q6IF82 OR4A47 PTHR48002:SF102 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 4A47 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=15861|UniProtKB=Q9H5Z1 Q9H5Z1 DHX35 PTHR18934:SF136 ATP-DEPENDENT RNA HELICASE ATP-DEPENDENT RNA HELICASE DHX35-RELATED nucleic acid binding#GO:0003676;binding#GO:0005488;ATP-dependent activity#GO:0140657;RNA binding#GO:0003723;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543;helicase activity#GO:0004386;isomerase activity#GO:0016853 nuclear protein-containing complex#GO:0140513;catalytic step 2 spliceosome#GO:0071013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;spliceosomal complex#GO:0005681;nucleus#GO:0005634 RNA helicase#PC00032;RNA metabolism protein#PC00031 HUMAN|HGNC=26727|UniProtKB=Q4G0M1 Q4G0M1 ERFE PTHR24019:SF11 ADIPOLIN ERYTHROFERRONE hormone activity#GO:0005179;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207;peptide hormone#PC00179 HUMAN|HGNC=5133|UniProtKB=P28358 P28358 HOXD10 PTHR45874:SF5 HOMEOBOX PROTEIN ABDOMINAL-B HOMEOBOX PROTEIN HOX-D10 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 homeodomain transcription factor#PC00119 HUMAN|HGNC=25169|UniProtKB=Q96D09 Q96D09 GPRASP2 PTHR46414:SF1 PROTEIN BHLHB9-RELATED G PROTEIN-COUPLED RECEPTOR-ASSOCIATED SORTING PROTEIN 2 protein binding#GO:0005515;G protein-coupled receptor binding#GO:0001664;signaling receptor binding#GO:0005102;binding#GO:0005488 cytosol#GO:0005829;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=22983|UniProtKB=Q86YI8 Q86YI8 PHF13 PTHR14571:SF13 HISTONE-LYSINE N-METHYLTRANSFERASE SET-26-RELATED PHD FINGER PROTEIN 13 binding#GO:0005488;chromatin binding#GO:0003682 cellular process#GO:0009987;organelle organization#GO:0006996;mitotic sister chromatid segregation#GO:0000070;chromosome organization#GO:0051276;mitotic cell cycle process#GO:1903047;cellular component organization or biogenesis#GO:0071840;chromosome segregation#GO:0007059;mitotic cell cycle#GO:0000278;mitotic nuclear division#GO:0140014;cell cycle process#GO:0022402;sister chromatid segregation#GO:0000819;nuclear chromosome segregation#GO:0098813;cellular component organization#GO:0016043;cell cycle#GO:0007049;chromosome condensation#GO:0030261;mitotic chromosome condensation#GO:0007076;organelle fission#GO:0048285;nuclear division#GO:0000280 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=10325|UniProtKB=P83731 P83731 RPL24 PTHR10792:SF44 60S RIBOSOMAL PROTEIN L24 LARGE RIBOSOMAL SUBUNIT PROTEIN EL24 mRNA binding#GO:0003729;structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;binding#GO:0005488;structural molecule activity#GO:0005198;RNA binding#GO:0003723 cytoplasmic translation#GO:0002181;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;translation#GO:0006412 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;intracellular organelle#GO:0043229;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;cytosol#GO:0005829;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625;ribosome#GO:0005840 ribosomal protein#PC00202 HUMAN|HGNC=29564|UniProtKB=Q9BSU1 Q9BSU1 PHAF1 PTHR13465:SF5 UPF0183 PROTEIN PHAGOSOME ASSEMBLY FACTOR 1 protein transport#GO:0015031;post-Golgi vesicle-mediated transport#GO:0006892;cellular localization#GO:0051641;localization#GO:0051179;localization within membrane#GO:0051668;establishment of protein localization to plasma membrane#GO:0061951;Golgi to plasma membrane protein transport#GO:0043001;Golgi to plasma membrane transport#GO:0006893;protein localization to plasma membrane#GO:0072659;protein localization to membrane#GO:0072657;intracellular protein localization#GO:0008104;vesicle-mediated transport to the plasma membrane#GO:0098876;establishment of localization#GO:0051234;transport#GO:0006810;Golgi vesicle transport#GO:0048193;protein localization to cell periphery#GO:1990778;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of protein localization to membrane#GO:0090150;macromolecule localization#GO:0033036 bounding membrane of organelle#GO:0098588;cell junction#GO:0030054;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;cytoplasmic vesicle membrane#GO:0030659;presynapse#GO:0098793;neuron projection#GO:0043005;secretory vesicle#GO:0099503;organelle subcompartment#GO:0031984;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;cell projection#GO:0042995;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;intracellular vesicle#GO:0097708;organelle membrane#GO:0031090;Golgi apparatus#GO:0005794;somatodendritic compartment#GO:0036477;transport vesicle#GO:0030133;transport vesicle membrane#GO:0030658;endomembrane system#GO:0012505;vesicle membrane#GO:0012506;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;dendritic tree#GO:0097447;dendrite#GO:0030425;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;synaptic vesicle membrane#GO:0030672;vesicle#GO:0031982;synaptic vesicle#GO:0008021 HUMAN|HGNC=12674|UniProtKB=Q9Y277 Q9Y277 VDAC3 PTHR11743:SF28 VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL NON-SELECTIVE VOLTAGE-GATED ION CHANNEL VDAC3 monoatomic anion channel activity#GO:0005253;voltage-gated channel activity#GO:0022832;channel activity#GO:0015267;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;voltage-gated monoatomic anion channel activity#GO:0008308;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic anion transmembrane transporter activity#GO:0008509 establishment of localization in cell#GO:0051649;cellular process#GO:0009987;mitochondrial transport#GO:0006839;intracellular transport#GO:0046907;transport#GO:0006810;mitochondrial transmembrane transport#GO:1990542;localization#GO:0051179;transmembrane transport#GO:0055085;cellular localization#GO:0051641;establishment of localization#GO:0051234 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;outer membrane#GO:0019867;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;organelle envelope#GO:0031967;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;mitochondrial outer membrane#GO:0005741;cytoplasm#GO:0005737;organelle outer membrane#GO:0031968;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;membrane#GO:0016020 voltage-gated ion channel#PC00241 HUMAN|HGNC=220|UniProtKB=O75173 O75173 ADAMTS4 PTHR13723:SF38 ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 4 metalloendopeptidase activity#GO:0004222;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 cellular component organization#GO:0016043;primary metabolic process#GO:0044238;cellular process#GO:0009987;proteolysis#GO:0006508;metabolic process#GO:0008152;extracellular structure organization#GO:0043062;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;protein metabolic process#GO:0019538;extracellular matrix organization#GO:0030198;external encapsulating structure organization#GO:0045229 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012 metalloprotease#PC00153 HUMAN|HGNC=26862|UniProtKB=Q4G112 Q4G112 HSF5 PTHR10015:SF278 HEAT SHOCK TRANSCRIPTION FACTOR HEAT SHOCK FACTOR PROTEIN 5 helix-turn-helix transcription factor#PC00116;gene-specific transcriptional regulator#PC00264;winged helix/forkhead transcription factor#PC00246 HUMAN|HGNC=23483|UniProtKB=Q5JSL3 Q5JSL3 DOCK11 PTHR23317:SF81 DEDICATOR OF CYTOKINESIS DOCK DEDICATOR OF CYTOKINESIS PROTEIN 11 nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of cellular component biogenesis#GO:0044089;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cell projection organization#GO:0031344;regulation of response to stimulus#GO:0048583;regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of small GTPase mediated signal transduction#GO:0051056;regulation of filopodium assembly#GO:0051489;regulation of biological process#GO:0050789;regulation of Rho protein signal transduction#GO:0035023;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of plasma membrane bounded cell projection assembly#GO:0120032;regulation of cellular component biogenesis#GO:0044087;regulation of cell communication#GO:0010646;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;positive regulation of cell projection organization#GO:0031346;positive regulation of cellular component organization#GO:0051130;regulation of cell projection assembly#GO:0060491 G-protein modulator#PC00022;protein-binding activity modulator#PC00095;guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=16642|UniProtKB=Q9H2A7 Q9H2A7 CXCL16 PTHR14385:SF0 CXC CHEMOKINE LIGAND C-X-C MOTIF CHEMOKINE 16 signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;chemokine activity#GO:0008009;G protein-coupled receptor binding#GO:0001664;cargo receptor activity#GO:0038024;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;cytokine activity#GO:0005125;binding#GO:0005488;cytokine receptor binding#GO:0005126;signaling receptor binding#GO:0005102;protein binding#GO:0005515;chemokine receptor binding#GO:0042379;low-density lipoprotein particle receptor activity#GO:0005041;molecular function activator activity#GO:0140677 regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;positive regulation of cell motility#GO:2000147;locomotion#GO:0040011;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell motility#GO:0048870;chemotaxis#GO:0006935;immune system process#GO:0002376;cellular response to chemical stimulus#GO:0070887;mononuclear cell migration#GO:0071674;cell chemotaxis#GO:0060326;regulation of cell motility#GO:2000145;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;positive regulation of cell migration#GO:0030335;lymphocyte migration#GO:0072676;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;taxis#GO:0042330;response to chemical#GO:0042221;cell migration#GO:0016477;regulation of cell migration#GO:0030334;leukocyte migration#GO:0050900;positive regulation of locomotion#GO:0040017;response to external stimulus#GO:0009605;leukocyte chemotaxis#GO:0030595 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 chemokine#PC00074;cytokine#PC00083 HUMAN|HGNC=3999|UniProtKB=P02792 P02792 FTL PTHR11431:SF47 FERRITIN FERRITIN LIGHT CHAIN iron ion binding#GO:0005506;ferrous iron binding#GO:0008198;metal ion binding#GO:0046872;cation binding#GO:0043169;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;transition metal ion binding#GO:0046914 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 storage protein#PC00210 HUMAN|HGNC=25621|UniProtKB=Q9NUZ1 Q9NUZ1 ACOXL PTHR10909:SF378 ELECTRON TRANSPORT OXIDOREDUCTASE ACYL-COENZYME A OXIDASE-LIKE PROTEIN heterocyclic compound binding#GO:1901363;oxidoreductase activity#GO:0016491;nucleotide binding#GO:0000166;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;fatty acid binding#GO:0005504;lipid binding#GO:0008289;ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265;small molecule binding#GO:0036094;binding#GO:0005488;carboxylic acid binding#GO:0031406;anion binding#GO:0043168;flavin adenine dinucleotide binding#GO:0050660;organic acid binding#GO:0043177 monocarboxylic acid catabolic process#GO:0072329;lipid catabolic process#GO:0016042;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;lipid modification#GO:0030258;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;fatty acid oxidation#GO:0019395;lipid metabolic process#GO:0006629;fatty acid beta-oxidation#GO:0006635;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;small molecule catabolic process#GO:0044282;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;lipid oxidation#GO:0034440;fatty acid catabolic process#GO:0009062;oxoacid metabolic process#GO:0043436 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;peroxisome#GO:0005777;microbody#GO:0042579;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=8487|UniProtKB=Q13415 Q13415 ORC1 PTHR10763:SF23 CELL DIVISION CONTROL PROTEIN 6-RELATED ORIGIN RECOGNITION COMPLEX SUBUNIT 1 DNA replication origin binding#GO:0003688;nucleic acid binding#GO:0003676;binding#GO:0005488;sequence-specific DNA binding#GO:0043565;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;sequence-specific double-stranded DNA binding#GO:1990837 macromolecule metabolic process#GO:0043170;DNA-templated DNA replication#GO:0006261;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;DNA replication initiation#GO:0006270;nucleobase-containing compound metabolic process#GO:0006139;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular process#GO:0009987;DNA replication#GO:0006260 nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;protein-containing complex#GO:0032991;nuclear origin of replication recognition complex#GO:0005664;membraneless organelle#GO:0043228;origin recognition complex#GO:0000808;nuclear protein-containing complex#GO:0140513;chromosome#GO:0005694;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 replication origin binding protein#PC00199 HUMAN|HGNC=28201|UniProtKB=Q5BJH2 Q5BJH2 TMEM128 PTHR31134:SF1 TRANSMEMBRANE PROTEIN 128 TRANSMEMBRANE PROTEIN 128 HUMAN|HGNC=14348|UniProtKB=O43464 O43464 HTRA2 PTHR22939:SF127 SERINE PROTEASE FAMILY S1C HTRA-RELATED SERINE PROTEASE HTRA2, MITOCHONDRIAL serine-type peptidase activity#GO:0008236;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096 biological regulation#GO:0065007;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;positive regulation of apoptotic process#GO:0043065;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;regulation of apoptotic process#GO:0042981;positive regulation of programmed cell death#GO:0043068;regulation of cellular process#GO:0050794;regulation of programmed cell death#GO:0043067;primary metabolic process#GO:0044238;programmed cell death#GO:0012501;regulation of biological process#GO:0050789;cell death#GO:0008219;protein metabolic process#GO:0019538;proteolysis#GO:0006508 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 serine protease#PC00203;protease#PC00190 HUMAN|HGNC=25848|UniProtKB=Q96GQ5 Q96GQ5 RUSF1 PTHR12770:SF31 RUS1 FAMILY PROTEIN C16ORF58 RUS FAMILY MEMBER 1 HUMAN|HGNC=30093|UniProtKB=Q9UJX0 Q9UJX0 OSGIN1 PTHR15192:SF15 PROTEIN CBG05349 OXIDATIVE STRESS-INDUCED GROWTH INHIBITOR 1 growth factor activity#GO:0008083;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772 negative regulation of cellular process#GO:0048523;negative regulation of biological process#GO:0048519;regulation of growth#GO:0040008;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cell growth#GO:0001558;regulation of cellular component organization#GO:0051128;negative regulation of cell growth#GO:0030308;biological regulation#GO:0065007 HUMAN|HGNC=24339|UniProtKB=Q5EBN2 Q5EBN2 TRIM61 PTHR24103:SF677 E3 UBIQUITIN-PROTEIN LIGASE TRIM TRIPARTITE MOTIF-CONTAINING PROTEIN 61-RELATED catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;immune system process#GO:0002376;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;immune response#GO:0006955;defense response to symbiont#GO:0140546;defense response to other organism#GO:0098542;biological regulation#GO:0065007;response to other organism#GO:0051707;regulation of biosynthetic process#GO:0009889;innate immune response#GO:0045087;response to external stimulus#GO:0009605;regulation of gene expression#GO:0010468;defense response#GO:0006952 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=6943|UniProtKB=Q07820 Q07820 MCL1 PTHR11256:SF46 BCL-2 RELATED INDUCED MYELOID LEUKEMIA CELL DIFFERENTIATION PROTEIN MCL-1 channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;cell death#GO:0008219;mitochondrial fusion#GO:0008053;programmed cell death#GO:0012501;apoptotic signaling pathway#GO:0097190;DNA damage response#GO:0006974;positive regulation of neuron apoptotic process#GO:0043525;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;negative regulation of apoptotic process#GO:0043066;positive regulation of cellular process#GO:0048522;intrinsic apoptotic signaling pathway#GO:0097193;cellular response to stress#GO:0033554;signaling#GO:0023052;response to stimulus#GO:0050896;extrinsic apoptotic signaling pathway#GO:0097191;positive regulation of programmed cell death#GO:0043068;release of cytochrome c from mitochondria#GO:0001836;regulation of biological process#GO:0050789;apoptotic process#GO:0006915;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;cellular component organization#GO:0016043;cellular component organization or biogenesis#GO:0071840;positive regulation of apoptotic process#GO:0043065;regulation of apoptotic process#GO:0042981;cell surface receptor signaling pathway#GO:0007166;mitochondrion organization#GO:0007005;apoptotic mitochondrial changes#GO:0008637;organelle fusion#GO:0048284;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;negative regulation of programmed cell death#GO:0043069;cellular process#GO:0009987;regulation of neuron apoptotic process#GO:0043523;intrinsic apoptotic signaling pathway in response to DNA damage#GO:0008630;organelle organization#GO:0006996;response to stress#GO:0006950 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;organelle envelope#GO:0031967;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;outer membrane#GO:0019867;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;organelle outer membrane#GO:0031968;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;membrane#GO:0016020;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;mitochondrial outer membrane#GO:0005741 CCKR signaling map#P06959>MCL1#G07275;CCKR signaling map#P06959>MCL1#G06982;Apoptosis signaling pathway#P00006>Mcl1#P00308 HUMAN|HGNC=26477|UniProtKB=Q96MV1 Q96MV1 TLCD4 PTHR13439:SF1 CT120 PROTEIN TLC DOMAIN-CONTAINING PROTEIN 4 homeostatic process#GO:0042592;lipid homeostasis#GO:0055088;chemical homeostasis#GO:0048878 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 transferase#PC00220;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=19650|UniProtKB=O43529 O43529 CHST10 PTHR12137:SF2 CARBOHYDRATE SULFOTRANSFERASE CARBOHYDRATE SULFOTRANSFERASE 10 transferase activity, transferring sulphur-containing groups#GO:0016782;sulfotransferase activity#GO:0008146;transferase activity#GO:0016740;catalytic activity#GO:0003824 glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;biosynthetic process#GO:0009058;proteoglycan biosynthetic process#GO:0030166;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;proteoglycan metabolic process#GO:0006029 transferase#PC00220 HUMAN|HGNC=56|UniProtKB=O15440 O15440 ABCC5 PTHR24223:SF196 ATP-BINDING CASSETTE SUB-FAMILY C ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 5 cellular process#GO:0009987;transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085 basolateral plasma membrane#GO:0016323;basal part of cell#GO:0045178;membrane#GO:0016020;basal plasma membrane#GO:0009925;cell periphery#GO:0071944;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 ATP-binding cassette (ABC) transporter#PC00003 HUMAN|HGNC=10372|UniProtKB=P05386 P05386 RPLP1 PTHR45696:SF32 60S ACIDIC RIBOSOMAL PROTEIN P1 LARGE RIBOSOMAL SUBUNIT PROTEIN P1 binding#GO:0005488;kinase activator activity#GO:0019209;enzyme regulator activity#GO:0030234;ribonucleoprotein complex binding#GO:0043021;protein-containing complex binding#GO:0044877;molecular function activator activity#GO:0140677;structural constituent of ribosome#GO:0003735;enzyme activator activity#GO:0008047;protein kinase activator activity#GO:0030295;protein kinase regulator activity#GO:0019887;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;structural molecule activity#GO:0005198 metabolic process#GO:0008152;translation#GO:0006412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;cytoplasmic translation#GO:0002181;biosynthetic process#GO:0009058 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;ribosome#GO:0005840;cytosol#GO:0005829;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625 ribosomal protein#PC00202 HUMAN|HGNC=13819|UniProtKB=Q9NYB5 Q9NYB5 SLCO1C1 PTHR11388:SF99 ORGANIC ANION TRANSPORTER SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 1C1 secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 cellular process#GO:0009987;transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085 cell periphery#GO:0071944;basal plasma membrane#GO:0009925;membrane#GO:0016020;basal part of cell#GO:0045178;basolateral plasma membrane#GO:0016323;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590 transporter#PC00227 HUMAN|HGNC=28792|UniProtKB=Q9Y546 Q9Y546 LRRC42 PTHR31994:SF3 LEUCINE-RICH REPEAT-CONTAINING PROTEIN 42 LEUCINE-RICH REPEAT-CONTAINING PROTEIN 42 HUMAN|HGNC=9007|UniProtKB=Q96J94 Q96J94 PIWIL1 PTHR22891:SF46 EUKARYOTIC TRANSLATION INITIATION FACTOR 2C PIWI-LIKE PROTEIN 1 RNA binding#GO:0003723;nuclease activity#GO:0004518;nucleic acid binding#GO:0003676;binding#GO:0005488;catalytic activity, acting on RNA#GO:0140098;RNA endonuclease activity#GO:0004521;endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640 cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;RNA processing#GO:0006396;gene expression#GO:0010467;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;gamete generation#GO:0007276;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;macromolecule biosynthetic process#GO:0009059;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of biosynthetic process#GO:0009890;biosynthetic process#GO:0009058;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;male gamete generation#GO:0048232;developmental process#GO:0032502;regulatory ncRNA-mediated gene silencing#GO:0031047;spermatogenesis#GO:0007283;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulatory ncRNA processing#GO:0070918;nucleic acid metabolic process#GO:0090304;developmental process involved in reproduction#GO:0003006;primary metabolic process#GO:0044238;reproductive process#GO:0022414;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;sexual reproduction#GO:0019953;piRNA processing#GO:0034587;multicellular organismal reproductive process#GO:0048609 nucleus#GO:0005634;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;supramolecular complex#GO:0099080;organelle#GO:0043226;ribonucleoprotein granule#GO:0035770;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;P granule#GO:0043186;membraneless organelle#GO:0043228 translational protein#PC00263;translation initiation factor#PC00224;translation factor#PC00223 HUMAN|HGNC=26711|UniProtKB=Q9UFG5 Q9UFG5 C19orf25 PTHR34766:SF1 UPF0449 PROTEIN C19ORF25 UPF0449 PROTEIN C19ORF25 establishment of localization#GO:0051234;vesicle-mediated transport#GO:0016192;localization#GO:0051179;cellular process#GO:0009987;transport#GO:0006810;Golgi vesicle transport#GO:0048193;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890 HUMAN|HGNC=7190|UniProtKB=Q9NZB8 Q9NZB8 MOCS1 PTHR22960:SF26 MOLYBDOPTERIN COFACTOR SYNTHESIS PROTEIN A MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN 1 lyase activity#GO:0016829;phosphorus-oxygen lyase activity#GO:0016849;carbon-carbon lyase activity#GO:0016830;catalytic activity#GO:0003824 metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;organophosphate biosynthetic process#GO:0090407;protein metabolic process#GO:0019538;organophosphate metabolic process#GO:0019637;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;cellular process#GO:0009987;biosynthetic process#GO:0009058 HUMAN|HGNC=15553|UniProtKB=Q96SF2 Q96SF2 CCT8L2 PTHR11353:SF100 CHAPERONIN T-COMPLEX PROTEIN 1 SUBUNIT THETA-LIKE 1-RELATED primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;protein folding#GO:0006457;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;protein folding chaperone complex#GO:0101031;chaperonin-containing T-complex#GO:0005832;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 chaperonin#PC00073 HUMAN|HGNC=23764|UniProtKB=Q6UWV6 Q6UWV6 ENPP7 PTHR10151:SF63 ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE ECTONUCLEOTIDE PYROPHOSPHATASE_PHOSPHODIESTERASE FAMILY MEMBER 7 hydrolase activity, acting on ester bonds#GO:0016788;phospholipase activity#GO:0120569;catalytic activity#GO:0003824;lipase activity#GO:0016298;phosphoric diester hydrolase activity#GO:0008081;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578 lipid metabolic process#GO:0006629;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;phospholipid metabolic process#GO:0006644;sphingomyelin metabolic process#GO:0006684 plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cell periphery#GO:0071944;microvillus#GO:0005902;actin-based cell projection#GO:0098858;membrane#GO:0016020;actin cytoskeleton#GO:0015629;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 hydrolase#PC00121;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=1373|UniProtKB=P00918 P00918 CA2 PTHR18952:SF120 CARBONIC ANHYDRASE CARBONIC ANHYDRASE 2 lyase activity#GO:0016829;carbon-oxygen lyase activity#GO:0016835;hydro-lyase activity#GO:0016836;catalytic activity#GO:0003824 intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;regulation of biological quality#GO:0065008;regulation of pH#GO:0006885;regulation of intracellular pH#GO:0051453;intracellular monoatomic cation homeostasis#GO:0030003;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;homeostatic process#GO:0042592;biological regulation#GO:0065007;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion homeostasis#GO:0050801 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;apical part of cell#GO:0045177;membrane#GO:0016020 metabolite interconversion enzyme#PC00262;dehydratase#PC00091 HUMAN|HGNC=30700|UniProtKB=Q63HK5 Q63HK5 TSHZ3 PTHR12487:SF5 TEASHIRT-RELATED TEASHIRT HOMOLOG 3 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676 system process#GO:0003008;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of system process#GO:0044057;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of multicellular organismal process#GO:0051239;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;nervous system process#GO:0050877;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 gene-specific transcriptional regulator#PC00264;zinc finger transcription factor#PC00244 HUMAN|HGNC=1915|UniProtKB=O14646 O14646 CHD1 PTHR45623:SF7 CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED ATP-DEPENDENT CHROMATIN REMODELER CHD1 catalytic activity, acting on DNA#GO:0140097;hydrolase activity, acting on acid anhydrides#GO:0016817;protein binding#GO:0005515;ATP-dependent activity, acting on DNA#GO:0008094;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP-dependent activity#GO:0140657;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;pyrophosphatase activity#GO:0016462;histone binding#GO:0042393;DNA binding#GO:0003677;hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887;nucleic acid binding#GO:0003676;chromatin binding#GO:0003682 protein-DNA complex organization#GO:0071824;nucleosome organization#GO:0034728;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;chromatin organization#GO:0006325;chromatin remodeling#GO:0006338;cellular component organization#GO:0016043;cellular process#GO:0009987 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694;nucleus#GO:0005634;chromatin#GO:0000785 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=4638|UniProtKB=P09211 P09211 GSTP1 PTHR11571:SF141 GLUTATHIONE S-TRANSFERASE GLUTATHIONE S-TRANSFERASE P glutathione transferase activity#GO:0004364;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765 cellular process#GO:0009987;metabolic process#GO:0008152;sulfur compound metabolic process#GO:0006790;glutathione metabolic process#GO:0006749;modified amino acid metabolic process#GO:0006575 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 transferase#PC00220 HUMAN|HGNC=30570|UniProtKB=Q7L945 Q7L945 ZNF627 PTHR24379:SF78 KRAB AND ZINC FINGER DOMAIN-CONTAINING ZINC FINGER PROTEIN 627 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218;C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HUMAN|HGNC=22203|UniProtKB=O94880 O94880 PHF14 PTHR13793:SF150 PHD FINGER PROTEINS PHD FINGER PROTEIN 14 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;histone reader activity#GO:0140566;chromatin-protein adaptor activity#GO:0140463 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;chromatin organization#GO:0006325;biological regulation#GO:0065007;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;chromatin remodeling#GO:0006338;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=23486|UniProtKB=Q9H0M4 Q9H0M4 ZCWPW1 PTHR15999:SF2 ZINC FINGER CW-TYPE PWWP DOMAIN PROTEIN 1 ZINC FINGER CW-TYPE PWWP DOMAIN PROTEIN 1 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=20304|UniProtKB=Q8TEF2 Q8TEF2 C10orf105 PTHR38325:SF1 MCG55969 GENE, 17455-RELATED HUMAN|HGNC=26653|UniProtKB=Q8IYL2 Q8IYL2 TRMT44 PTHR21210:SF0 TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED methyltransferase activity#GO:0008168;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity#GO:0003824;transferase activity#GO:0016740;tRNA methyltransferase activity#GO:0008175;RNA methyltransferase activity#GO:0008173;catalytic activity, acting on RNA#GO:0140098 macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;cellular process#GO:0009987;tRNA methylation#GO:0030488;macromolecule biosynthetic process#GO:0009059;RNA methylation#GO:0001510;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;methylation#GO:0032259;nucleic acid biosynthetic process#GO:0141187;macromolecule methylation#GO:0043414;RNA modification#GO:0009451;RNA biosynthetic process#GO:0032774;tRNA modification#GO:0006400;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 HUMAN|HGNC=8763|UniProtKB=Q53EL6 Q53EL6 PDCD4 PTHR12626:SF3 PROGRAMMED CELL DEATH 4 PROGRAMMED CELL DEATH PROTEIN 4 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;cytosol#GO:0005829;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 translation factor#PC00223 HUMAN|HGNC=9692|UniProtKB=P26022 P26022 PTX3 PTHR46943:SF1 PENTRAXIN-RELATED PROTEIN PTX3 PENTRAXIN-RELATED PROTEIN PTX3 protein-containing complex binding#GO:0044877;protein binding#GO:0005515;binding#GO:0005488;complement binding#GO:0001848 response to other organism#GO:0051707;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;defense response to other organism#GO:0098542;response to stimulus#GO:0050896;immune response#GO:0006955;defense response to symbiont#GO:0140546;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;defense response#GO:0006952;response to external stimulus#GO:0009605;innate immune response#GO:0045087;immune system process#GO:0002376 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=1316|UniProtKB=Q9HC35 Q9HC35 EML4 PTHR13720:SF11 WD-40 REPEAT PROTEIN ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 4 cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;microtubule binding#GO:0008017;binding#GO:0005488;protein binding#GO:0005515 microtubule-based process#GO:0007017;cytoskeleton organization#GO:0007010;microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;spindle#GO:0005819;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;mitotic spindle#GO:0072686;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microtubule cytoskeleton#GO:0015630 microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=28995|UniProtKB=Q6P996 Q6P996 PDXDC1 PTHR42735:SF1 FAMILY NOT NAMED PYRIDOXAL-DEPENDENT DECARBOXYLASE DOMAIN-CONTAINING PROTEIN 1-RELATED aldehyde-lyase activity#GO:0016832;lyase activity#GO:0016829;carbon-carbon lyase activity#GO:0016830;catalytic activity#GO:0003824 sphingolipid catabolic process#GO:0030149;primary metabolic process#GO:0044238;cellular process#GO:0009987;lipid catabolic process#GO:0016042;catabolic process#GO:0009056;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;lipid metabolic process#GO:0006629 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=2856|UniProtKB=P52824 P52824 DGKQ PTHR11255:SF125 DIACYLGLYCEROL KINASE DIACYLGLYCEROL KINASE THETA phosphotransferase activity, alcohol group as acceptor#GO:0016773;lipid kinase activity#GO:0001727;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;regulation of cellular process#GO:0050794;glycerolipid metabolic process#GO:0046486;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165 cellular anatomical structure#GO:0110165;membrane#GO:0016020 metabolite interconversion enzyme#PC00262;kinase#PC00137 HUMAN|HGNC=29130|UniProtKB=O94927 O94927 HAUS5 PTHR28588:SF1 HAUS AUGMIN-LIKE COMPLEX SUBUNIT 5 HAUS AUGMIN-LIKE COMPLEX SUBUNIT 5 microtubule cytoskeleton organization#GO:0000226;organelle assembly#GO:0070925;cell cycle process#GO:0022402;centrosome cycle#GO:0007098;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;cell cycle#GO:0007049;microtubule-based process#GO:0007017;microtubule organizing center organization#GO:0031023;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;chromosome segregation#GO:0007059;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;cellular process#GO:0009987;spindle assembly#GO:0051225;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085 intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;cellular anatomical structure#GO:0110165;organelle#GO:0043226;HAUS complex#GO:0070652;microtubule cytoskeleton#GO:0015630;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;centrosome#GO:0005813 HUMAN|HGNC=19439|UniProtKB=Q7Z418 Q7Z418 KCNK18 PTHR11003:SF346 POTASSIUM CHANNEL, SUBFAMILY K POTASSIUM CHANNEL SUBFAMILY K MEMBER 18 voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;potassium channel activity#GO:0005267;outward rectifier potassium channel activity#GO:0015271 cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;potassium ion transport#GO:0006813;transport#GO:0006810;monoatomic ion transport#GO:0006811;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=31862|UniProtKB=Q7Z3S9 Q7Z3S9 NOTCH2NLA PTHR12916:SF16 CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2 NOTCH HOMOLOG 2 N-TERMINAL-LIKE PROTEIN A-RELATED protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 cell surface receptor signaling pathway#GO:0007166;Notch signaling pathway#GO:0007219;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007 oxidase#PC00175;oxidoreductase#PC00176 HUMAN|HGNC=11531|UniProtKB=O75478 O75478 TADA2A PTHR12374:SF85 TRANSCRIPTIONAL ADAPTOR 2 ADA2 -RELATED TRANSCRIPTIONAL ADAPTER 2-ALPHA chromatin binding#GO:0003682;transcription regulator activity#GO:0140110;binding#GO:0005488;transcription coregulator activity#GO:0003712;transcription coactivator activity#GO:0003713 cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;chromatin remodeling#GO:0006338;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of RNA biosynthetic process#GO:2001141;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 chromatin#GO:0000785;nucleus#GO:0005634;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;transferase complex#GO:1990234;histone acetyltransferase complex#GO:0000123;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;protein acetyltransferase complex#GO:0031248;membrane-bounded organelle#GO:0043227;acetyltransferase complex#GO:1902493;intracellular anatomical structure#GO:0005622;SAGA-type complex#GO:0070461 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HUMAN|HGNC=52395|UniProtKB=A0A1B0GWH4 A0A1B0GWH4 HSFX3 PTHR10015:SF140 HEAT SHOCK TRANSCRIPTION FACTOR HEAT SHOCK TRANSCRIPTION FACTOR, X-LINKED MEMBER 3-RELATED gene-specific transcriptional regulator#PC00264;winged helix/forkhead transcription factor#PC00246;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=34417|UniProtKB=Q09MP3 Q09MP3 RAD51AP2 PTHR39229:SF1 MCG1037962 RAD51-ASSOCIATED PROTEIN 2 HUMAN|HGNC=4110|UniProtKB=Q5JUK9 Q5JUK9 PAGE3 PTHR14047:SF1 P ANTIGEN FAMILY MEMBER 5-RELATED P ANTIGEN FAMILY MEMBER 3 HUMAN|HGNC=8594|UniProtKB=O75781 O75781 PALM PTHR10498:SF6 PARALEMMIN-RELATED PARALEMMIN-1 cytoskeletal adaptor activity#GO:0008093;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;protein-membrane adaptor activity#GO:0043495 positive regulation of cellular component organization#GO:0051130;animal gross anatomical part developmental process#GO:0160108;G protein-coupled receptor signaling pathway#GO:0007186;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;regulation of cellular component biogenesis#GO:0044087;signaling#GO:0023052;regulation of plasma membrane bounded cell projection assembly#GO:0120032;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;nervous system development#GO:0007399;positive regulation of cellular component biogenesis#GO:0044089;positive regulation of cell projection organization#GO:0031346;synapse organization#GO:0050808;regulation of cell projection assembly#GO:0060491;system development#GO:0048731;anatomical structure development#GO:0048856;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;cell junction organization#GO:0034330;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;developmental process#GO:0032502;regulation of cell projection organization#GO:0031344;adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway#GO:0007193;regulation of filopodium assembly#GO:0051489;regulation of plasma membrane bounded cell projection organization#GO:0120035;positive regulation of cellular process#GO:0048522;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;developmental maturation#GO:0021700 membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005;plasma membrane region#GO:0098590;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;cytoskeleton#GO:0005856;synaptic membrane#GO:0097060;membraneless organelle#GO:0043228;cell junction#GO:0030054;postsynapse#GO:0098794;actin cytoskeleton#GO:0015629;actin-based cell projection#GO:0098858;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;neuron spine#GO:0044309;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;filopodium#GO:0030175;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=2347|UniProtKB=O43889 O43889 CREB3 PTHR45996:SF4 AGAP001464-PB CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>CPB#P00702;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>CREB#P00713;Transcription regulation by bZIP transcription factor#P00055>CREB#P01383 HUMAN|HGNC=40042|UniProtKB=C9JI98 C9JI98 TMEM238 PTHR28613:SF5 SI:CH211-232M10.4-RELATED TRANSMEMBRANE PROTEIN 238 HUMAN|HGNC=28318|UniProtKB=A6PVS8 A6PVS8 LRRIQ3 PTHR46723:SF1 LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 3 LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 3 HUMAN|HGNC=6012|UniProtKB=P26951 P26951 IL3RA PTHR23036:SF179 CYTOKINE RECEPTOR INTERLEUKIN-3 RECEPTOR SUBUNIT ALPHA transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488;molecular transducer activity#GO:0060089;protein binding#GO:0005515;cytokine receptor activity#GO:0004896;signaling receptor activity#GO:0038023;cytokine binding#GO:0019955;immune receptor activity#GO:0140375 cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of cellular process#GO:0048522;biological regulation#GO:0065007;response to cytokine#GO:0034097;response to chemical#GO:0042221;cell surface receptor signaling pathway#GO:0007166;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;positive regulation of cell population proliferation#GO:0008284;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cytokine-mediated signaling pathway#GO:0019221;response to peptide#GO:1901652;regulation of cell population proliferation#GO:0042127;cell communication#GO:0007154 cell periphery#GO:0071944;signaling receptor complex#GO:0043235;membrane#GO:0016020;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 Interleukin signaling pathway#P00036>Receptor subunit alpha#P00992 HUMAN|HGNC=16633|UniProtKB=Q9Y3D5 Q9Y3D5 MRPS18C PTHR13479:SF57 30S RIBOSOMAL PROTEIN S18 SMALL RIBOSOMAL SUBUNIT PROTEIN BS18M structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;membrane-enclosed lumen#GO:0031974;mitochondrial small ribosomal subunit#GO:0005763;membraneless organelle#GO:0043228;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;ribosome#GO:0005840;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;organellar ribosome#GO:0000313;intracellular anatomical structure#GO:0005622;mitochondrial ribosome#GO:0005761;small ribosomal subunit#GO:0015935;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013 translational protein#PC00263;ribosomal protein#PC00202 HUMAN|HGNC=33145|UniProtKB=Q6VEQ5 Q6VEQ5 WASH2P PTHR23331:SF5 CXYORF1 WAS PROTEIN FAMILY HOMOLOG 2-RELATED cellular component organization#GO:0016043;export from cell#GO:0140352;cytosolic transport#GO:0016482;endocytic recycling#GO:0032456;actin nucleation#GO:0045010;actin cytoskeleton organization#GO:0030036;localization within membrane#GO:0051668;actin filament-based process#GO:0030029;secretion by cell#GO:0032940;supramolecular fiber organization#GO:0097435;localization#GO:0051179;secretion#GO:0046903;cellular localization#GO:0051641;establishment of localization in cell#GO:0051649;Arp2/3 complex-mediated actin nucleation#GO:0034314;cellular process#GO:0009987;retrograde transport, endosome to Golgi#GO:0042147;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;vesicle-mediated transport#GO:0016192;transport#GO:0006810;intracellular transport#GO:0046907;endosomal transport#GO:0016197;actin filament organization#GO:0007015;exocytosis#GO:0006887;vesicle-mediated transport to the plasma membrane#GO:0098876;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234 recycling endosome#GO:0055037;endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;intracellular vesicle#GO:0097708;vesicle#GO:0031982;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 membrane traffic protein#PC00150 HUMAN|HGNC=26897|UniProtKB=Q8NEM1 Q8NEM1 ZNF680 PTHR24384:SF121 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED ZINC FINGER PROTEIN 680 double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 HUMAN|HGNC=25044|UniProtKB=Q587J7 Q587J7 TDRD12 PTHR22655:SF2 ATP-DEPENDENT RNA HELICASE TDRD12-RELATED ATP-DEPENDENT RNA HELICASE TDRD12-RELATED nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;gene expression#GO:0010467;RNA processing#GO:0006396;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of metabolic process#GO:0009892;negative regulation of cellular process#GO:0048523;regulatory ncRNA-mediated gene silencing#GO:0031047;regulation of biosynthetic process#GO:0009889;regulatory ncRNA processing#GO:0070918;macromolecule metabolic process#GO:0043170;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;macromolecule biosynthetic process#GO:0009059;negative regulation of macromolecule metabolic process#GO:0010605;biosynthetic process#GO:0009058;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;piRNA processing#GO:0034587;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;RNA biosynthetic process#GO:0032774 protein-containing complex#GO:0032991 HUMAN|HGNC=16654|UniProtKB=Q8N5N7 Q8N5N7 MRPL50 PTHR31542:SF1 39A RIBOSOMAL PROTEIN L50, MITOCHONDRIAL LARGE RIBOSOMAL SUBUNIT PROTEIN ML50 intracellular anatomical structure#GO:0005622;mitochondrial ribosome#GO:0005761;organellar ribosome#GO:0000313;membrane-bounded organelle#GO:0043227;large ribosomal subunit#GO:0015934;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;ribosome#GO:0005840;mitochondrion#GO:0005739;membraneless organelle#GO:0043228;mitochondrial large ribosomal subunit#GO:0005762;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974 ribosomal protein#PC00202;translational protein#PC00263 HUMAN|HGNC=17282|UniProtKB=Q86UR5 Q86UR5 RIMS1 PTHR12157:SF18 REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN 1 structural molecule activity#GO:0005198;structural constituent of synapse#GO:0098918 neurotransmitter secretion#GO:0007269;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;establishment of localization#GO:0051234;synaptic vesicle cycle#GO:0099504;transport#GO:0006810;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;regulation of cell communication#GO:0010646;modulation of chemical synaptic transmission#GO:0050804;signal release from synapse#GO:0099643;chemical synaptic transmission#GO:0007268;secretion#GO:0046903;regulation of secretion#GO:0051046;cell communication#GO:0007154;localization#GO:0051179;regulation of exocytosis#GO:0017157;trans-synaptic signaling#GO:0099537;signal release#GO:0023061;regulation of trans-synaptic signaling#GO:0099177;vesicle-mediated transport#GO:0016192;cellular component assembly#GO:0022607;neurotransmitter transport#GO:0006836;synaptic signaling#GO:0099536;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;synaptic vesicle exocytosis#GO:0016079;vesicle-mediated transport in synapse#GO:0099003;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;regulation of transport#GO:0051049;regulation of localization#GO:0032879;exocytosis#GO:0006887;regulated exocytosis#GO:0045055;exocytic process#GO:0140029;regulation of neurotransmitter secretion#GO:0046928;regulation of synaptic vesicle exocytosis#GO:2000300;signaling#GO:0023052;export from cell#GO:0140352;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;cellular localization#GO:0051641;regulation of secretion by cell#GO:1903530;secretion by cell#GO:0032940;regulation of neurotransmitter transport#GO:0051588;regulation of signaling#GO:0023051 membrane#GO:0016020;cell periphery#GO:0071944;cell cortex#GO:0005938;presynapse#GO:0098793;synapse#GO:0045202;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;presynaptic membrane#GO:0042734;cytoplasm#GO:0005737;plasma membrane#GO:0005886;synaptic membrane#GO:0097060;presynaptic active zone#GO:0048786;cell junction#GO:0030054;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 Synaptic vesicle trafficking#P05734>RIM1alpha/2alpha#P05776 HUMAN|HGNC=28644|UniProtKB=Q86UF2 Q86UF2 CTAGE6 PTHR23158:SF57 MELANOMA INHIBITORY ACTIVITY-RELATED CTAGE FAMILY MEMBER 15-RELATED protein transport#GO:0015031;secretion by cell#GO:0032940;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;secretion#GO:0046903;localization#GO:0051179;protein secretion#GO:0009306;export from cell#GO:0140352;protein localization to extracellular region#GO:0071692;establishment of protein localization to extracellular region#GO:0035592;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;Golgi vesicle transport#GO:0048193;transport#GO:0006810;intracellular transport#GO:0046907;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;macromolecule localization#GO:0033036 endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endoplasmic reticulum exit site#GO:0070971;organelle membrane#GO:0031090;membrane#GO:0016020;endomembrane system#GO:0012505;cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;intracellular membrane-bounded organelle#GO:0043231 membrane traffic protein#PC00150 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HUMAN|HGNC=6707|UniProtKB=P33241 P33241 LSP1 PTHR18949:SF1 CALDESMON LYMPHOCYTE-SPECIFIC PROTEIN 1 non-motor actin binding protein#PC00165 HUMAN|HGNC=20286|UniProtKB=Q9H3H1 Q9H3H1 TRIT1 PTHR11088:SF89 TRNA DIMETHYLALLYLTRANSFERASE TRNA DIMETHYLALLYLTRANSFERASE catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765 macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;RNA biosynthetic process#GO:0032774;tRNA modification#GO:0006400;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 RNA processing factor#PC00147 HUMAN|HGNC=16896|UniProtKB=Q7Z6M1 Q7Z6M1 RABEPK PTHR46647:SF1 RAB9 EFFECTOR PROTEIN WITH KELCH MOTIFS RAB9 EFFECTOR PROTEIN WITH KELCH MOTIFS HUMAN|HGNC=49178|UniProtKB=H0Y7S4 H0Y7S4 PRAMEF26 PTHR14224:SF112 SIMILAR TO PREFERENTIALLY EXPRESSED ANTIGEN IN MELANOMA-LIKE 3 PRAME FAMILY MEMBER 11-RELATED molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;enzyme-substrate adaptor activity#GO:0140767;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056 intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;ubiquitin ligase complex#GO:0000151;transferase complex#GO:1990234;catalytic complex#GO:1902494;Cul2-RING ubiquitin ligase complex#GO:0031462;cullin-RING ubiquitin ligase complex#GO:0031461;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 HUMAN|HGNC=28191|UniProtKB=Q9BSF0 Q9BSF0 AKAP19 PTHR36471:SF1 SMALL MEMBRANE A-KINASE ANCHOR PROTEIN A-KINASE ANCHORING PROTEIN 19 scaffold/adaptor protein#PC00226 HUMAN|HGNC=30717|UniProtKB=Q7RTY3 Q7RTY3 PRSS45P PTHR24256:SF140 TRYPTASE-RELATED SERINE PROTEASE 45-RELATED catalytic activity#GO:0003824;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;primary metabolic process#GO:0044238;metabolic process#GO:0008152;proteolysis#GO:0006508 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 serine protease#PC00203 HUMAN|HGNC=31230|UniProtKB=Q8NGT9 Q8NGT9 OR2A1 PTHR26453:SF115 OLFACTORY RECEPTOR OLFACTORY RECEPTOR-RELATED olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 response to stimulus#GO:0050896;response to chemical#GO:0042221;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;detection of chemical stimulus#GO:0009593;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;system process#GO:0003008;sensory perception#GO:0007600;nervous system process#GO:0050877;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=29165|UniProtKB=Q9Y2K2 Q9Y2K2 SIK3 PTHR24346:SF42 MAP/MICROTUBULE AFFINITY-REGULATING KINASE SERINE_THREONINE-PROTEIN KINASE SIK3 protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;signal transduction#GO:0007165;cellular process#GO:0009987;organelle organization#GO:0006996;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;microtubule cytoskeleton organization#GO:0000226;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular component organization#GO:0016043 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=54403|UniProtKB=F5H094 F5H094 SLCO1B3-SLCO1B7 PTHR11388:SF154 ORGANIC ANION TRANSPORTER SLCO1B3-SLCO1B7 READTHROUGH TRANSCRIPT PROTEIN-RELATED secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;carboxylic acid transmembrane transporter activity#GO:0046943;bile acid transmembrane transporter activity#GO:0015125;active transmembrane transporter activity#GO:0022804 lipid localization#GO:0010876;transport#GO:0006810;carboxylic acid transport#GO:0046942;organic acid transport#GO:0015849;bile acid and bile salt transport#GO:0015721;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;monocarboxylic acid transport#GO:0015718;organic hydroxy compound transport#GO:0015850;macromolecule localization#GO:0033036;cellular process#GO:0009987;lipid transport#GO:0006869 membrane#GO:0016020;basal part of cell#GO:0045178;basolateral plasma membrane#GO:0016323;cell periphery#GO:0071944;basal plasma membrane#GO:0009925;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;plasma membrane#GO:0005886 transporter#PC00227 HUMAN|HGNC=19840|UniProtKB=Q8NDC0 Q8NDC0 MAPK1IP1L PTHR35973:SF1 MAPK-INTERACTING AND SPINDLE-STABILIZING PROTEIN-LIKE MAPK-INTERACTING AND SPINDLE-STABILIZING PROTEIN-LIKE HUMAN|HGNC=2916|UniProtKB=O60479 O60479 DLX3 PTHR24327:SF28 HOMEOBOX PROTEIN HOMEOBOX PROTEIN DLX-3 nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;tissue development#GO:0009888;multicellular organismal process#GO:0032501;epithelial cell differentiation#GO:0030855;epithelium development#GO:0060429;regulation of nucleobase-containing compound metabolic process#GO:0019219;embryo development#GO:0009790;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;developmental process#GO:0032502;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;multicellular organism development#GO:0007275;regulation of gene expression#GO:0010468;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;animal gross anatomical part developmental process#GO:0160108;chordate embryonic development#GO:0043009;embryo development ending in birth or egg hatching#GO:0009792;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;skeletal system development#GO:0001501;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731 gene-specific transcriptional regulator#PC00264;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=8082|UniProtKB=Q9GZU5 Q9GZU5 NYX PTHR24373:SF264 SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN NYCTALOPIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=2340|UniProtKB=P78560 P78560 CRADD PTHR15034:SF6 DEATH DOMAIN-CONTAINING PROTEIN CRADD DEATH DOMAIN-CONTAINING PROTEIN CRADD protein binding#GO:0005515;enzyme binding#GO:0019899;protease binding#GO:0002020;binding#GO:0005488 signal transduction by p53 class mediator#GO:0072331;regulation of apoptotic signaling pathway#GO:2001233;regulation of signaling#GO:0023051;cellular response to stress#GO:0033554;positive regulation of signaling#GO:0023056;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of programmed cell death#GO:0043067;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;signal transduction in response to DNA damage#GO:0042770;regulation of biological process#GO:0050789;positive regulation of cell communication#GO:0010647;positive regulation of programmed cell death#GO:0043068;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;positive regulation of apoptotic signaling pathway#GO:2001235;regulation of cell communication#GO:0010646;signaling#GO:0023052;regulation of response to stimulus#GO:0048583;regulation of apoptotic process#GO:0042981;DNA damage response#GO:0006974;positive regulation of apoptotic process#GO:0043065;response to stress#GO:0006950;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 Apoptosis signaling pathway#P00006>RAIDD#P00294 HUMAN|HGNC=18602|UniProtKB=Q7RTU1 Q7RTU1 TCF23 PTHR23349:SF58 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST TRANSCRIPTION FACTOR 23 nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 basic helix-loop-helix transcription factor#PC00055;DNA-binding transcription factor#PC00218 HUMAN|HGNC=7836|UniProtKB=Q8TAU0 Q8TAU0 NKX2-3 PTHR24340:SF32 HOMEOBOX PROTEIN NKX HOMEOBOX PROTEIN NKX-2.3 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=14662|UniProtKB=Q96BH1 Q96BH1 RNF25 PTHR13198:SF4 RING FINGER PROTEIN 25 E3 UBIQUITIN-PROTEIN LIGASE RNF25 catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630 modification-dependent macromolecule catabolic process#GO:0043632;translation#GO:0006412;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;cellular component disassembly#GO:0022411;organelle disassembly#GO:1903008;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;rescue of stalled cytosolic ribosome#GO:0072344;modification-dependent protein catabolic process#GO:0019941;protein biosynthetic process#GO:0160307;cytoplasmic translation#GO:0002181;catabolic process#GO:0009056;macromolecule catabolic process#GO:0009057;translational elongation#GO:0006414;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;organelle organization#GO:0006996;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;biosynthetic process#GO:0009058 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=29030|UniProtKB=O43159 O43159 RRP8 PTHR12787:SF0 RIBOSOMAL RNA-PROCESSING PROTEIN 8 RIBOSOMAL RNA-PROCESSING PROTEIN 8 catalytic activity, acting on a rRNA#GO:0140102;rRNA (adenine) methyltransferase activity#GO:0016433;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;RNA methyltransferase activity#GO:0008173;catalytic activity, acting on RNA#GO:0140098;rRNA methyltransferase activity#GO:0008649;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a nucleic acid#GO:0140640 heterochromatin formation#GO:0031507;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;nucleolus organization#GO:0007000;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;chromatin organization#GO:0006325;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;negative regulation of cellular process#GO:0048523;regulation of biosynthetic process#GO:0009889;nucleus organization#GO:0006997;regulation of gene expression#GO:0010468;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cellular component assembly#GO:0022607;heterochromatin organization#GO:0070828;cellular component organization or biogenesis#GO:0071840;negative regulation of gene expression, epigenetic#GO:0045814 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991 HUMAN|HGNC=16145|UniProtKB=Q96M20 Q96M20 CNBD2 PTHR23011:SF43 CYCLIC NUCLEOTIDE-BINDING DOMAIN CONTAINING PROTEIN CYCLIC NUCLEOTIDE-BINDING DOMAIN-CONTAINING PROTEIN 2 ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265;anion binding#GO:0043168;small molecule binding#GO:0036094;binding#GO:0005488;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;nucleotide binding#GO:0000166;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;ribonucleotide binding#GO:0032553 sexual reproduction#GO:0019953;spermatogenesis#GO:0007283;developmental process#GO:0032502;multicellular organismal reproductive process#GO:0048609;developmental process involved in reproduction#GO:0003006;gamete generation#GO:0007276;male gamete generation#GO:0048232;reproductive process#GO:0022414 HUMAN|HGNC=11375|UniProtKB=P48723 P48723 HSPA13 PTHR19375:SF169 HEAT SHOCK PROTEIN 70KDA HEAT SHOCK 70 KDA PROTEIN 13 heat shock protein binding#GO:0031072;hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;ATP-dependent activity#GO:0140657;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;ATP hydrolysis activity#GO:0016887;hydrolase activity#GO:0016787;protein binding#GO:0005515 primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;protein maturation#GO:0051604;protein folding#GO:0006457;biosynthetic process#GO:0009058;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;protein refolding#GO:0042026 nucleus#GO:0005634;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 chaperone#PC00072;Hsp70 family chaperone#PC00027 HUMAN|HGNC=53849|UniProtKB=P0DW11 P0DW11 TAF11L6 PTHR13218:SF18 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11-RELATED TATA-BOX-BINDING PROTEIN-ASSOCIATED FACTOR 11-LIKE PROTEIN 10-RELATED protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;RNA polymerase II preinitiation complex assembly#GO:0051123;DNA-templated transcription#GO:0006351;DNA-templated transcription initiation#GO:0006352;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;transcription initiation at RNA polymerase II promoter#GO:0006367;cellular component biogenesis#GO:0044085;nucleobase-containing compound metabolic process#GO:0006139;protein-DNA complex assembly#GO:0065004;biosynthetic process#GO:0009058;cellular component assembly#GO:0022607;gene expression#GO:0010467;transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-DNA complex organization#GO:0071824 protein-containing complex#GO:0032991;transcription factor TFIID complex#GO:0005669;membrane-enclosed lumen#GO:0031974;RNA polymerase II transcription regulator complex#GO:0090575;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;transcription regulator complex#GO:0005667;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;RNA polymerase II, holoenzyme#GO:0016591;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 general transcription factor#PC00259;RNA metabolism protein#PC00031 HUMAN|HGNC=7203|UniProtKB=P41217 P41217 CD200 PTHR46841:SF3 OX-2 MEMBRANE GLYCOPROTEIN OX-2 MEMBRANE GLYCOPROTEIN cell adhesion mediator activity#GO:0098631;cell adhesion molecule binding#GO:0050839;binding#GO:0005488;cell-cell adhesion mediator activity#GO:0098632;protein binding#GO:0005515 cell-cell adhesion#GO:0098609;cellular process#GO:0009987;negative regulation of response to stimulus#GO:0048585;regulation of response to external stimulus#GO:0032101;biological regulation#GO:0065007;negative regulation of response to external stimulus#GO:0032102;regulation of response to stress#GO:0080134;regulation of response to stimulus#GO:0048583;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of defense response#GO:0031348;negative regulation of inflammatory response#GO:0050728;heterotypic cell-cell adhesion#GO:0034113;regulation of defense response#GO:0031347;regulation of inflammatory response#GO:0050727;cell adhesion#GO:0007155 axon#GO:0030424;neuron projection#GO:0043005;cell body#GO:0044297;plasma membrane bounded cell projection#GO:0120025;neuronal cell body#GO:0043025;cell projection#GO:0042995;somatodendritic compartment#GO:0036477;cellular anatomical structure#GO:0110165;cell surface#GO:0009986 HUMAN|HGNC=25876|UniProtKB=Q8IV13 Q8IV13 CCNJL PTHR10177:SF63 CYCLINS CYCLIN-J-LIKE PROTEIN cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538;enzyme regulator activity#GO:0030234;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;cyclin-dependent protein kinase regulator activity#GO:0019914;protein kinase regulator activity#GO:0019887 cell cycle G1/S phase transition#GO:0044843;cell cycle process#GO:0022402;cellular process#GO:0009987;cell cycle#GO:0007049;mitotic cell cycle#GO:0000278;cell cycle phase transition#GO:0044770;mitotic cell cycle phase transition#GO:0044772;G1/S transition of mitotic cell cycle#GO:0000082;mitotic cell cycle process#GO:1903047 microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;transferase complex#GO:1990234;membraneless organelle#GO:0043228;protein kinase complex#GO:1902911;microtubule cytoskeleton#GO:0015630;nucleus#GO:0005634;protein-containing complex#GO:0032991;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 kinase activator#PC00138 HUMAN|HGNC=28139|UniProtKB=Q9BT56 Q9BT56 SPX PTHR28590:SF1 SPEXIN SPEXIN neuropeptide hormone activity#GO:0005184;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;hormone activity#GO:0005179;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018 biological regulation#GO:0065007;regulation of multicellular organismal process#GO:0051239;positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789;positive regulation of multicellular organismal process#GO:0051240;regulation of muscle system process#GO:0090257;regulation of smooth muscle contraction#GO:0006940;regulation of muscle contraction#GO:0006937;regulation of system process#GO:0044057 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=6535|UniProtKB=P00338 P00338 LDHA PTHR43128:SF10 L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+)) L-LACTATE DEHYDROGENASE A CHAIN oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824 carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;monocarboxylic acid catabolic process#GO:0072329;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;small molecule catabolic process#GO:0044282;pyruvate metabolic process#GO:0006090;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;generation of precursor metabolites and energy#GO:0006091;energy derivation by oxidation of organic compounds#GO:0015980 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 dehydrogenase#PC00092;oxidoreductase#PC00176 HUMAN|HGNC=9662|UniProtKB=P78324 P78324 SIRPA PTHR19971:SF37 SIGNAL-REGULATORY PROTEIN BETA TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE SUBSTRATE 1 positive regulation of immune system process#GO:0002684;positive regulation of cell-cell adhesion#GO:0022409;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of transport#GO:0051050;regulation of cell adhesion#GO:0030155;regulation of T cell activation#GO:0050863;positive regulation of T cell activation#GO:0050870;positive regulation of endocytosis#GO:0045807;positive regulation of cell activation#GO:0050867;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;positive regulation of leukocyte cell-cell adhesion#GO:1903039;regulation of leukocyte cell-cell adhesion#GO:1903037;positive regulation of leukocyte activation#GO:0002696;regulation of endocytosis#GO:0030100;regulation of localization#GO:0032879;regulation of transport#GO:0051049;regulation of leukocyte activation#GO:0002694;positive regulation of multicellular organismal process#GO:0051240;regulation of cell activation#GO:0050865;positive regulation of cell adhesion#GO:0045785;regulation of biological process#GO:0050789;regulation of cell-cell adhesion#GO:0022407;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of cellular component organization#GO:0051128;regulation of lymphocyte activation#GO:0051249;positive regulation of cellular component organization#GO:0051130;positive regulation of lymphocyte activation#GO:0051251 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=29022|UniProtKB=Q69YQ0 Q69YQ0 SPECC1L PTHR23167:SF18 CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED CYTOSPIN-A cellular component organization or biogenesis#GO:0071840;actin cytoskeleton organization#GO:0030036;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;actin filament-based process#GO:0030029 actin filament#GO:0005884;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;supramolecular complex#GO:0099080;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;actin cytoskeleton#GO:0015629;cellular anatomical structure#GO:0110165;organelle#GO:0043226 scaffold/adaptor protein#PC00226 HUMAN|HGNC=31932|UniProtKB=Q5VVY1 Q5VVY1 NTMT2 PTHR12753:SF2 AD-003 - RELATED N-TERMINAL XAA-PRO-LYS N-METHYLTRANSFERASE 2 catalytic activity, acting on a protein#GO:0140096;protein methyltransferase activity#GO:0008276;transferase activity#GO:0016740;catalytic activity#GO:0003824;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;transferase activity, transferring one-carbon groups#GO:0016741 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 methyltransferase#PC00155;transferase#PC00220 HUMAN|HGNC=22957|UniProtKB=Q496A3 Q496A3 SPATS1 PTHR35845:SF1 SPERMATOGENESIS-ASSOCIATED SERINE-RICH PROTEIN 1 SPERMATOGENESIS-ASSOCIATED SERINE-RICH PROTEIN 1 HUMAN|HGNC=25008|UniProtKB=Q9NWV8 Q9NWV8 BABAM1 PTHR15660:SF2 BRISC AND BRCA1-A COMPLEX MEMBER 1 BRISC AND BRCA1-A COMPLEX MEMBER 1 mitotic cell cycle#GO:0000278;regulation of cellular process#GO:0050794;mitotic DNA damage checkpoint signaling#GO:0044773;cellular response to stimulus#GO:0051716;mitotic cell cycle checkpoint signaling#GO:0007093;regulation of cell cycle phase transition#GO:1901987;cell cycle#GO:0007049;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;regulation of G2/M transition of mitotic cell cycle#GO:0010389;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;DNA damage checkpoint signaling#GO:0000077;mitotic G2/M transition checkpoint#GO:0044818;regulation of mitotic cell cycle#GO:0007346;mitotic DNA integrity checkpoint signaling#GO:0044774;regulation of cell cycle G2/M phase transition#GO:1902749;DNA integrity checkpoint signaling#GO:0031570;mitotic cell cycle process#GO:1903047;macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;negative regulation of cell cycle process#GO:0010948;DNA repair#GO:0006281;negative regulation of cellular process#GO:0048523;signaling#GO:0023052;regulation of cell cycle#GO:0051726;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;signal transduction in response to DNA damage#GO:0042770;cell cycle process#GO:0022402;negative regulation of biological process#GO:0048519;negative regulation of cell cycle phase transition#GO:1901988;negative regulation of mitotic cell cycle#GO:0045930;mitotic G2 DNA damage checkpoint signaling#GO:0007095;regulation of mitotic cell cycle phase transition#GO:1901990;cellular response to stress#GO:0033554;regulation of cell cycle process#GO:0010564;negative regulation of mitotic cell cycle phase transition#GO:1901991;cell cycle checkpoint signaling#GO:0000075;negative regulation of G2/M transition of mitotic cell cycle#GO:0010972;signal transduction#GO:0007165;cellular process#GO:0009987;response to stress#GO:0006950;double-strand break repair#GO:0006302;negative regulation of cell cycle G2/M phase transition#GO:1902750;negative regulation of cell cycle#GO:0045786;metabolic process#GO:0008152;DNA metabolic process#GO:0006259 organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;nuclear body#GO:0016604;protein-containing complex#GO:0032991;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228 HUMAN|HGNC=7585|UniProtKB=P12829 P12829 MYL4 PTHR23048:SF1 MYOSIN LIGHT CHAIN 1, 3 MYOSIN LIGHT CHAIN 4 binding#GO:0005488;polypeptide conformation or assembly isomerase activity#GO:0120544;actin binding#GO:0003779;ATP-dependent activity#GO:0140657;protein binding#GO:0005515;catalytic activity#GO:0003824;microfilament motor activity#GO:0000146;actin monomer binding#GO:0003785;macromolecular conformation isomerase activity#GO:0120543;cytoskeletal protein binding#GO:0008092;cytoskeletal motor activity#GO:0003774;isomerase activity#GO:0016853;structural molecule activity#GO:0005198 circulatory system process#GO:0003013;muscle contraction#GO:0006936;cardiac muscle contraction#GO:0060048;system process#GO:0003008;heart contraction#GO:0060047;heart process#GO:0003015;muscle system process#GO:0003012;multicellular organismal process#GO:0032501;blood circulation#GO:0008015;striated muscle contraction#GO:0006941 organelle#GO:0043226;cellular anatomical structure#GO:0110165;actin cytoskeleton#GO:0015629;A band#GO:0031672;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;myofibril#GO:0030016;intracellular organelle#GO:0043229;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;contractile muscle fiber#GO:0043292;myosin complex#GO:0016459;sarcomere#GO:0030017;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=10915|UniProtKB=Q9Y666 Q9Y666 SLC12A7 PTHR11827:SF47 SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS SOLUTE CARRIER FAMILY 12 MEMBER 7 potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;symporter activity#GO:0015293;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;chloride transmembrane transporter activity#GO:0015108;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic anion transmembrane transporter activity#GO:0008509;secondary active transmembrane transporter activity#GO:0015291 potassium ion transmembrane transport#GO:0071805;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813;cellular process#GO:0009987;monoatomic anion transport#GO:0006820;inorganic anion transport#GO:0015698;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810;chloride transport#GO:0006821 cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;plasma membrane#GO:0005886;membrane#GO:0016020;apical plasma membrane#GO:0016324;cell periphery#GO:0071944;apical part of cell#GO:0045177 secondary carrier transporter#PC00258 HUMAN|HGNC=25072|UniProtKB=Q5MNZ6 Q5MNZ6 WDR45B PTHR11227:SF18 WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED WD REPEAT DOMAIN PHOSPHOINOSITIDE-INTERACTING PROTEIN 3 lipid binding#GO:0008289;phosphatidylinositol bisphosphate binding#GO:1902936;binding#GO:0005488;small molecule binding#GO:0036094;anion binding#GO:0043168;ion binding#GO:0043167;protein-macromolecule adaptor activity#GO:0030674;phosphatidylinositol-3-phosphate binding#GO:0032266;phosphatidylinositol phosphate binding#GO:1901981;phospholipid binding#GO:0005543;molecular adaptor activity#GO:0060090 metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;cellular component organization or biogenesis#GO:0071840;autophagosome assembly#GO:0000045;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;autophagy#GO:0006914;cellular process#GO:0009987;autophagosome organization#GO:1905037;cellular component assembly#GO:0022607;carbohydrate catabolic process#GO:0016052;process utilizing autophagic mechanism#GO:0061919;glucan metabolic process#GO:0044042;cellular component organization#GO:0016043;polysaccharide catabolic process#GO:0000272;polysaccharide metabolic process#GO:0005976;glucan catabolic process#GO:0009251;autophagy of mitochondrion#GO:0000422;generation of precursor metabolites and energy#GO:0006091;pexophagy#GO:0000425;macromolecule metabolic process#GO:0043170;energy derivation by oxidation of organic compounds#GO:0015980;intracellular protein localization#GO:0008104;glycogen catabolic process#GO:0005980;macromolecule localization#GO:0033036;macroautophagy#GO:0016236;energy reserve metabolic process#GO:0006112;organelle assembly#GO:0070925;localization#GO:0051179;vacuole organization#GO:0007033;glycogen metabolic process#GO:0005977;primary metabolic process#GO:0044238;catabolic process#GO:0009056;carbohydrate metabolic process#GO:0005975 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;phagophore assembly site#GO:0000407;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HUMAN|HGNC=20090|UniProtKB=Q96KC8 Q96KC8 DNAJC1 PTHR44653:SF2 DNAJ HOMOLOG SUBFAMILY C MEMBER 1 DNAJ HOMOLOG SUBFAMILY C MEMBER 1 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 chaperone#PC00072 HUMAN|HGNC=31792|UniProtKB=Q8NFC6 Q8NFC6 BOD1L1 PTHR31532:SF10 BIORIENTATION OF CHROMOSOMES IN CELL DIVISION 1 FAMILY MEMBER BIORIENTATION OF CHROMOSOMES IN CELL DIVISION PROTEIN 1-LIKE 1 DNA metabolic process#GO:0006259;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;DNA-templated DNA replication#GO:0006261;DNA replication#GO:0006260;cellular process#GO:0009987;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;replication fork processing#GO:0031297;nucleobase-containing compound metabolic process#GO:0006139 nuclear protein-containing complex#GO:0140513;Set1C/COMPASS complex#GO:0048188;transferase complex#GO:1990234;histone methyltransferase complex#GO:0035097;protein-containing complex#GO:0032991;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;organelle#GO:0043226;nucleoplasm#GO:0005654;methyltransferase complex#GO:0034708;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233 HUMAN|HGNC=18676|UniProtKB=Q86XP3 Q86XP3 DDX42 PTHR24031:SF125 RNA HELICASE ATP-DEPENDENT RNA HELICASE DDX42 macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 RNA helicase#PC00032;RNA metabolism protein#PC00031 HUMAN|HGNC=5647|UniProtKB=A0A087WSY4 A0A087WSY4 IGHV4-30-2 PTHR23266:SF323 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 4-30-2-RELATED antigen binding#GO:0003823;binding#GO:0005488 immune response#GO:0006955;adaptive immune response#GO:0002250;response to stimulus#GO:0050896;immune effector process#GO:0002252;immune system process#GO:0002376;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=12580|UniProtKB=O75631 O75631 UPK3A PTHR15446:SF17 UROPLAKIN III UROPLAKIN-3A establishment of localization#GO:0051234;localization#GO:0051179;water transport#GO:0006833;fluid transport#GO:0042044;nitrogen compound transport#GO:0071705;transport#GO:0006810 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HUMAN|HGNC=8127|UniProtKB=O15294 O15294 OGT PTHR44366:SF1 UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT acetylglucosaminyltransferase activity#GO:0008375;glycosyltransferase activity#GO:0016757;catalytic activity, acting on a protein#GO:0140096;UDP-glycosyltransferase activity#GO:0008194;hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740 metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein O-linked glycosylation#GO:0006493;biosynthetic process#GO:0009058 protein modifying enzyme#PC00260 HUMAN|HGNC=18095|UniProtKB=Q30KQ6 Q30KQ6 DEFB114 PTHR20515:SF16 BETA-DEFENSIN BETA-DEFENSIN 114 signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;G protein-coupled receptor binding#GO:0001664;chemokine receptor binding#GO:0042379;protein binding#GO:0005515;molecular function activator activity#GO:0140677;cytokine receptor binding#GO:0005126;signaling receptor binding#GO:0005102;binding#GO:0005488 defense response#GO:0006952;response to external stimulus#GO:0009605;response to other organism#GO:0051707;cell migration#GO:0016477;taxis#GO:0042330;response to chemical#GO:0042221;cellular process#GO:0009987;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;cell chemotaxis#GO:0060326;chemotaxis#GO:0006935;defense response to bacterium#GO:0042742;cellular response to chemical stimulus#GO:0070887;response to bacterium#GO:0009617;locomotion#GO:0040011;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;cell motility#GO:0048870;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 antimicrobial response protein#PC00051;defense/immunity protein#PC00090 HUMAN|HGNC=25631|UniProtKB=Q96MT7 Q96MT7 CFAP44 PTHR14885:SF3 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 43-RELATED CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 44 peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;catalytic activity#GO:0003824 cilium assembly#GO:0060271;cellular component organization#GO:0016043;sperm motility#GO:0097722;cell differentiation#GO:0030154;cell projection organization#GO:0030030;gamete generation#GO:0007276;cellular process involved in reproduction in multicellular organism#GO:0022412;cell development#GO:0048468;spermatid differentiation#GO:0048515;cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;sperm flagellum assembly#GO:0120316;cilium-dependent cell motility#GO:0060285;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cilium movement involved in cell motility#GO:0060294;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;motile cilium assembly#GO:0044458;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;developmental process involved in reproduction#GO:0003006;germ cell development#GO:0007281;cell motility#GO:0048870;microtubule-based movement#GO:0007018;reproductive process#GO:0022414;organelle assembly#GO:0070925;sexual reproduction#GO:0019953;spermatid development#GO:0007286;microtubule bundle formation#GO:0001578;microtubule cytoskeleton organization#GO:0000226;anatomical structure development#GO:0048856;axoneme assembly#GO:0035082;multicellular organismal reproductive process#GO:0048609;male gamete generation#GO:0048232;plasma membrane bounded cell projection organization#GO:0120036;flagellated sperm motility#GO:0030317;plasma membrane bounded cell projection assembly#GO:0120031;spermatogenesis#GO:0007283;developmental process#GO:0032502;cellular developmental process#GO:0048869;sperm axoneme assembly#GO:0007288 axoneme#GO:0005930;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytoskeleton#GO:0005856;cilium#GO:0005929;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;ciliary plasm#GO:0097014;organelle#GO:0043226;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232 HUMAN|HGNC=23459|UniProtKB=Q96P64 Q96P64 AGAP4 PTHR45819:SF7 CENTAURIN-GAMMA-1A ARF-GAP WITH GTPASE, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 4-RELATED molecular function activator activity#GO:0140677;hydrolase activity#GO:0016787;enzyme regulator activity#GO:0030234;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;molecular function regulator activity#GO:0098772;ribonucleoside triphosphate phosphatase activity#GO:0017111;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;enzyme activator activity#GO:0008047;catalytic activity#GO:0003824 G-protein modulator#PC00022;GTPase-activating protein#PC00257 HUMAN|HGNC=17163|UniProtKB=Q8NCC3 Q8NCC3 PLA2G15 PTHR11440:SF47 LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED LYSOSOMAL PHOSPHOLIPASE A AND ACYLTRANSFERASE acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;A2-type glycerophospholipase activity#GO:0004623;phospholipase activity#GO:0120569;hydrolase activity, acting on ester bonds#GO:0016788;transferase activity#GO:0016740;glycerophospholipase activity#GO:0004620;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689;lipase activity#GO:0016298;acyltransferase activity#GO:0016746 cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phospholipid metabolic process#GO:0006644;glycerophospholipid metabolic process#GO:0006650;glycerolipid metabolic process#GO:0046486;phosphatidylcholine metabolic process#GO:0046470;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;sphingolipid metabolic process#GO:0006665;ceramide metabolic process#GO:0006672 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;vacuole#GO:0005773;lysosome#GO:0005764;lytic vacuole#GO:0000323;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;extracellular region#GO:0005576;intracellular organelle#GO:0043229 acyltransferase#PC00042;transferase#PC00220 HUMAN|HGNC=7171|UniProtKB=O75900 O75900 MMP23B PTHR10201:SF7 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE-23 metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 cellular process#GO:0009987;cellular component organization#GO:0016043;catabolic process#GO:0009056;metabolic process#GO:0008152;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 Alzheimer disease-presenilin pathway#P00004>Matrix metalloprotease#P00130 HUMAN|HGNC=19971|UniProtKB=Q96G25 Q96G25 MED8 PTHR13074:SF9 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 8 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 8 general transcription factor#PC00259 HUMAN|HGNC=1866|UniProtKB=Q12798 Q12798 CETN1 PTHR23050:SF218 CALCIUM BINDING PROTEIN CENTRIN-1 calcium ion binding#GO:0005509;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;cation binding#GO:0043169;metal ion binding#GO:0046872 centrosome cycle#GO:0007098;cell cycle process#GO:0022402;cell cycle#GO:0007049;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;centriole replication#GO:0007099;organelle assembly#GO:0070925;microtubule cytoskeleton organization#GO:0000226;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;microtubule organizing center organization#GO:0031023;microtubule-based process#GO:0007017;centrosome duplication#GO:0051298;cellular component organization or biogenesis#GO:0071840 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;centrosome#GO:0005813;intracellular membrane-bounded organelle#GO:0043231;centriole#GO:0005814;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;microtubule cytoskeleton#GO:0015630 calmodulin-related#PC00061;calcium-binding protein#PC00060 HUMAN|HGNC=20773|UniProtKB=Q3ZCM7 Q3ZCM7 TUBB8 PTHR11588:SF429 TUBULIN TUBULIN BETA 8B-RELATED ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;structural molecule activity#GO:0005198;nucleotide binding#GO:0000166;nucleoside phosphate binding#GO:1901265;structural constituent of cytoskeleton#GO:0005200;binding#GO:0005488;guanyl nucleotide binding#GO:0019001;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;ribonucleotide binding#GO:0032553;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363 microtubule-based process#GO:0007017;microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010;mitotic cell cycle#GO:0000278;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;cell cycle#GO:0007049 microtubule cytoskeleton#GO:0015630;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512 cytoskeletal protein#PC00085;tubulin#PC00228 Cytoskeletal regulation by Rho GTPase#P00016>tubulin#P00526;Huntington disease#P00029>Microtubule#P00780;Huntington disease#P00029>beta-Tubulin#P00790 HUMAN|HGNC=19818|UniProtKB=Q9H329 Q9H329 EPB41L4B PTHR23280:SF18 4.1 G PROTEIN BAND 4.1-LIKE PROTEIN 4B cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;positive regulation of cell adhesion#GO:0045785;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;positive regulation of biological process#GO:0048518;actin cytoskeleton organization#GO:0030036;regulation of cell adhesion#GO:0030155;regulation of cellular process#GO:0050794;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;actomyosin structure organization#GO:0031032;actin filament-based process#GO:0030029;cellular component organization or biogenesis#GO:0071840 apical part of cell#GO:0045177;cellular anatomical structure#GO:0110165 cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165;actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=21019|UniProtKB=Q5XKL5 Q5XKL5 BTBD8 PTHR22427:SF2 GH15728P BTB_POZ DOMAIN-CONTAINING PROTEIN 8 HUMAN|HGNC=49210|UniProtKB=Q6P2S7 Q6P2S7 TTC41P PTHR19871:SF40 BETA TRANSDUCIN-RELATED PROTEIN TETRATRICOPEPTIDE REPEAT PROTEIN 41-RELATED HUMAN|HGNC=23710|UniProtKB=Q9BUG6 Q9BUG6 ZSCAN5A PTHR23226:SF138 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 5A-RELATED DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=23356|UniProtKB=Q5T0T0 Q5T0T0 MARCHF8 PTHR45981:SF4 LD02310P E3 UBIQUITIN-PROTEIN LIGASE MARCHF8 binding#GO:0005488;signaling receptor binding#GO:0005102;MHC protein binding#GO:0042287;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;protein binding#GO:0005515;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;immune response#GO:0006955;cellular process#GO:0009987;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;protein modification by small protein conjugation or removal#GO:0070647;immune system process#GO:0002376;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;antigen processing and presentation#GO:0019882;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;protein modification process#GO:0036211;response to stimulus#GO:0050896 late endosome membrane#GO:0031902;early endosome membrane#GO:0031901;lytic vacuole#GO:0000323;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;vesicle membrane#GO:0012506;membrane#GO:0016020;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;late endosome#GO:0005770;vacuole#GO:0005773;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;endosome membrane#GO:0010008;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;early endosome#GO:0005769;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular vesicle#GO:0097708;vesicle#GO:0031982;lysosome#GO:0005764;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=14559|UniProtKB=Q9UJZ1 Q9UJZ1 STOML2 PTHR43327:SF10 STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL transporter#PC00227 HUMAN|HGNC=26842|UniProtKB=Q494V2 Q494V2 CFAP100 PTHR21683:SF5 COILED-COIL DOMAIN-CONTAINING PROTEIN 42 LIKE-2-LIKE-RELATED CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 100 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cilium#GO:0005929;microtubule organizing center#GO:0005815;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microtubule cytoskeleton#GO:0015630 microtubule or microtubule-binding cytoskeletal protein#PC00157;non-motor microtubule binding protein#PC00166 HUMAN|HGNC=16392|UniProtKB=Q9H0X9 Q9H0X9 OSBPL5 PTHR10972:SF213 OXYSTEROL-BINDING PROTEIN-RELATED OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 5 steroid binding#GO:0005496;lipid binding#GO:0008289;cholesterol binding#GO:0015485;alcohol binding#GO:0043178;sterol binding#GO:0032934;binding#GO:0005488;small molecule binding#GO:0036094 establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810;lipid localization#GO:0010876;phospholipid transport#GO:0015914;organophosphate ester transport#GO:0015748;lipid transport#GO:0006869;macromolecule localization#GO:0033036 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;membrane#GO:0016020;cytosol#GO:0005829 transfer/carrier protein#PC00219 HUMAN|HGNC=30323|UniProtKB=Q8TDB6 Q8TDB6 DTX3L PTHR12622:SF41 DELTEX-RELATED E3 UBIQUITIN-PROTEIN LIGASE DTX3L ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=11843|UniProtKB=O43897 O43897 TLL1 PTHR10127:SF860 DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING TOLLOID-LIKE PROTEIN 1 catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 protein maturation#GO:0051604;multicellular organismal process#GO:0032501;regionalization#GO:0003002;gene expression#GO:0010467;biosynthetic process#GO:0009058;cellular process#GO:0009987;protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059;multicellular organism development#GO:0007275;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;developmental process#GO:0032502;primary metabolic process#GO:0044238;dorsal/ventral pattern formation#GO:0009953;anatomical structure development#GO:0048856;protein metabolic process#GO:0019538;proteolysis#GO:0006508;pattern specification process#GO:0007389 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease#PC00190;metalloprotease#PC00153 TGF-beta signaling pathway#P00052>TGFbeta#P01286 HUMAN|HGNC=2236|UniProtKB=Q9Y678 Q9Y678 COPG1 PTHR10261:SF3 COATOMER SUBUNIT GAMMA COATOMER SUBUNIT GAMMA-1 cellular process#GO:0009987;transport#GO:0006810;Golgi vesicle transport#GO:0048193;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;establishment of localization#GO:0051234;vesicle-mediated transport#GO:0016192;localization#GO:0051179 COPI vesicle coat#GO:0030126;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;Golgi-associated vesicle membrane#GO:0030660;coated vesicle membrane#GO:0030662;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;vesicle#GO:0031982;membrane coat#GO:0030117;coated membrane#GO:0048475;cytoplasmic vesicle#GO:0031410;coated vesicle#GO:0030135;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;COPI-coated vesicle#GO:0030137;cytoplasm#GO:0005737;vesicle coat#GO:0030120;membrane#GO:0016020;vesicle membrane#GO:0012506;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;Golgi-associated vesicle#GO:0005798;endoplasmic reticulum#GO:0005783 vesicle coat protein#PC00235 HUMAN|HGNC=24656|UniProtKB=Q9UBQ5 Q9UBQ5 EIF3K PTHR13022:SF0 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 11 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT K translation factor activity#GO:0180051;translation initiation factor activity#GO:0003743 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;translation#GO:0006412;translational initiation#GO:0006413;metabolic process#GO:0008152;biosynthetic process#GO:0009058;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;eukaryotic translation initiation factor 3 complex#GO:0005852 translation initiation factor#PC00224 HUMAN|HGNC=1131|UniProtKB=P78543 P78543 BTG2 PTHR22978:SF29 B-CELL TRANSLOCATION GENE PROTEIN BTG2 biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of cell population proliferation#GO:0042127;regulation of biological process#GO:0050789;negative regulation of cellular process#GO:0048523;negative regulation of cell population proliferation#GO:0008285;negative regulation of biological process#GO:0048519 nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=16055|UniProtKB=Q9BY10 Q9BY10 SLC46A2 PTHR23507:SF3 ZGC:174356 SOLUTE CARRIER FAMILY 46 MEMBER 2 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 cellular process#GO:0009987;transport#GO:0006810;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234 cellular anatomical structure#GO:0110165;membrane#GO:0016020 HUMAN|HGNC=19400|UniProtKB=Q8N328 Q8N328 PGBD3 PTHR47055:SF2 DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 2-RELATED DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;binding#GO:0005488;nucleic acid binding#GO:0003676 HUMAN|HGNC=24023|UniProtKB=Q6TDP4 Q6TDP4 KLHL17 PTHR24412:SF475 KELCH PROTEIN KELCH-LIKE PROTEIN 17 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;enzyme-substrate adaptor activity#GO:0140767;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056 cytoplasm#GO:0005737;cullin-RING ubiquitin ligase complex#GO:0031461;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;ubiquitin ligase complex#GO:0000151;Cul3-RING ubiquitin ligase complex#GO:0031463 scaffold/adaptor protein#PC00226 HUMAN|HGNC=34524|UniProtKB=A6NFH5 A6NFH5 FABP12 PTHR11955:SF76 FATTY ACID BINDING PROTEIN FATTY ACID-BINDING PROTEIN 12 ion binding#GO:0043167;carboxylic acid binding#GO:0031406;anion binding#GO:0043168;small molecule binding#GO:0036094;binding#GO:0005488;organic acid binding#GO:0043177;fatty acid binding#GO:0005504;lipid binding#GO:0008289 carboxylic acid transport#GO:0046942;transport#GO:0006810;organic acid transport#GO:0015849;lipid localization#GO:0010876;monocarboxylic acid transport#GO:0015718;fatty acid transport#GO:0015908;localization#GO:0051179;establishment of localization#GO:0051234;macromolecule localization#GO:0033036;lipid transport#GO:0006869 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cytosol#GO:0005829;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 transfer/carrier protein#PC00219 HUMAN|HGNC=20607|UniProtKB=Q8N6R1 Q8N6R1 SERP2 PTHR15601:SF20 STRESS ASSOCIATED ENDOPLASMIC RETICULUM PROTEIN SERP1/RAMP4 STRESS-ASSOCIATED ENDOPLASMIC RETICULUM PROTEIN 2 regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;response to topologically incorrect protein#GO:0035966;response to endoplasmic reticulum stress#GO:0034976;cellular response to unfolded protein#GO:0034620;cellular response to stress#GO:0033554;cellular response to topologically incorrect protein#GO:0035967;response to unfolded protein#GO:0006986;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;endoplasmic reticulum unfolded protein response#GO:0030968;response to stress#GO:0006950;signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 chaperone#PC00072 HUMAN|HGNC=9445|UniProtKB=P01236 P01236 PRL PTHR11417:SF5 SOMATOTROPIN,PROLACTIN PROLACTIN molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;molecular function activator activity#GO:0140677;hormone activity#GO:0005179;protein binding#GO:0005515;signaling receptor binding#GO:0005102;cytokine receptor binding#GO:0005126;binding#GO:0005488 regulation of multicellular organismal process#GO:0051239;positive regulation of biological process#GO:0048518;positive regulation of transport#GO:0051050;signal transduction#GO:0007165;cellular process#GO:0009987;animal organ development#GO:0048513;regulation of transport#GO:0051049;regulation of localization#GO:0032879;cell surface receptor signaling pathway#GO:0007166;response to stimulus#GO:0050896;regulation of body fluid levels#GO:0050878;signaling#GO:0023052;regulation of biological process#GO:0050789;multi-multicellular organism process#GO:0044706;positive regulation of multicellular organismal process#GO:0051240;regulation of multicellular organismal development#GO:2000026;positive regulation of signaling#GO:0023056;regulation of biological quality#GO:0065008;animal gross anatomical part developmental process#GO:0160108;positive regulation of secretion#GO:0051047;regulation of signaling#GO:0023051;positive regulation of response to stimulus#GO:0048584;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;response to nutrient levels#GO:0031667;positive regulation of cellular process#GO:0048522;developmental process#GO:0032502;positive regulation of developmental process#GO:0051094;regulation of receptor signaling pathway via JAK-STAT#GO:0046425;regulation of response to stimulus#GO:0048583;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of developmental process#GO:0050793;regulation of receptor signaling pathway via STAT#GO:1904892;reproductive process#GO:0022414;regulation of cell communication#GO:0010646;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;regulation of secretion#GO:0051046;cell communication#GO:0007154;anatomical structure development#GO:0048856;positive regulation of receptor signaling pathway via JAK-STAT#GO:0046427 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 peptide hormone#PC00179 Gonadotropin-releasing hormone receptor pathway#P06664>Prolactin#P06789 HUMAN|HGNC=19963|UniProtKB=Q6EMB2 Q6EMB2 TTLL5 PTHR12241:SF164 TUBULIN POLYGLUTAMYLASE TUBULIN POLYGLUTAMYLASE TTLL5 ligase activity, forming carbon-nitrogen bonds#GO:0016879;protein binding#GO:0005515;binding#GO:0005488;catalytic activity, acting on a protein#GO:0140096;ligase activity#GO:0016874;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;catalytic activity#GO:0003824 cilium movement involved in cell motility#GO:0060294;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;motile cilium assembly#GO:0044458;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;cilium assembly#GO:0060271;cellular component organization#GO:0016043;sperm motility#GO:0097722;gamete generation#GO:0007276;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell development#GO:0048468;cellular process involved in reproduction in multicellular organism#GO:0022412;spermatid differentiation#GO:0048515;cilium or flagellum-dependent cell motility#GO:0001539;cilium movement#GO:0003341;sperm flagellum assembly#GO:0120316;cilium-dependent cell motility#GO:0060285;cilium organization#GO:0044782;male gamete generation#GO:0048232;plasma membrane bounded cell projection organization#GO:0120036;plasma membrane bounded cell projection assembly#GO:0120031;flagellated sperm motility#GO:0030317;spermatogenesis#GO:0007283;developmental process#GO:0032502;cellular developmental process#GO:0048869;sperm axoneme assembly#GO:0007288;developmental process involved in reproduction#GO:0003006;germ cell development#GO:0007281;cell motility#GO:0048870;microtubule-based movement#GO:0007018;reproductive process#GO:0022414;organelle assembly#GO:0070925;spermatid development#GO:0007286;microtubule bundle formation#GO:0001578;sexual reproduction#GO:0019953;microtubule cytoskeleton organization#GO:0000226;anatomical structure development#GO:0048856;multicellular organismal reproductive process#GO:0048609;axoneme assembly#GO:0035082 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cilium#GO:0005929;microtubule organizing center#GO:0005815;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microtubule cytoskeleton#GO:0015630 microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=13258|UniProtKB=Q8WTT0 Q8WTT0 CLEC4C PTHR22802:SF423 C-TYPE LECTIN SUPERFAMILY MEMBER C-TYPE LECTIN DOMAIN FAMILY 4 MEMBER C binding#GO:0005488;carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 immune response#GO:0006955;defense response to symbiont#GO:0140546;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to other organism#GO:0051707;defense response to fungus#GO:0050832;response to stimulus#GO:0050896;defense response to other organism#GO:0098542;immune system process#GO:0002376;response to external stimulus#GO:0009605;defense response#GO:0006952;innate immune response#GO:0045087 cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020;plasma membrane#GO:0005886;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;cell surface#GO:0009986 membrane traffic protein#PC00150 HUMAN|HGNC=13444|UniProtKB=O95528 O95528 SLC2A10 PTHR48023:SF7 D-XYLOSE-PROTON SYMPORTER-LIKE 2 SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 10 sugar transmembrane transporter activity#GO:0051119;carbohydrate transmembrane transporter activity#GO:0015144;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 anatomical structure development#GO:0048856;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;multicellular organism development#GO:0007275;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;transport#GO:0006810;developmental process#GO:0032502;carbohydrate transport#GO:0008643;multicellular organismal process#GO:0032501;carbohydrate transmembrane transport#GO:0034219;circulatory system development#GO:0072359;cellular process#GO:0009987;D-glucose transmembrane transport#GO:1904659 membrane#GO:0016020;cellular anatomical structure#GO:0110165 primary active transporter#PC00068;transporter#PC00227 HUMAN|HGNC=4934|UniProtKB=P28067 P28067 HLA-DMA PTHR19944:SF50 MHC CLASS II-RELATED HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DM ALPHA CHAIN binding#GO:0005488;antigen binding#GO:0003823;peptide binding#GO:0042277;protein-containing complex binding#GO:0044877 immune system process#GO:0002376;regulation of lymphocyte activation#GO:0051249;positive regulation of multicellular organismal process#GO:0051240;regulation of cell activation#GO:0050865;regulation of biological process#GO:0050789;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;regulation of leukocyte activation#GO:0002694;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;positive regulation of leukocyte activation#GO:0002696;regulation of multicellular organismal process#GO:0051239;regulation of T cell activation#GO:0050863;cellular component assembly#GO:0022607;positive regulation of T cell activation#GO:0050870;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of immune system process#GO:0002684;positive regulation of cell-cell adhesion#GO:0022409;cellular component biogenesis#GO:0044085;antigen processing and presentation#GO:0019882;positive regulation of lymphocyte activation#GO:0051251;regulation of immune response#GO:0050776;regulation of cell-cell adhesion#GO:0022407;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;positive regulation of cell adhesion#GO:0045785;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;regulation of leukocyte cell-cell adhesion#GO:1903037;positive regulation of cell activation#GO:0050867;biological regulation#GO:0065007;positive regulation of leukocyte cell-cell adhesion#GO:1903039;regulation of cell adhesion#GO:0030155;positive regulation of response to stimulus#GO:0048584;positive regulation of cellular process#GO:0048522 vesicle#GO:0031982;lysosome#GO:0005764;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;lytic vacuole membrane#GO:0098852;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endosome#GO:0005768;endosome membrane#GO:0010008;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;cell periphery#GO:0071944;lysosomal membrane#GO:0005765;vesicle membrane#GO:0012506;membrane#GO:0016020;vacuole#GO:0005773;plasma membrane#GO:0005886;cytoplasm#GO:0005737;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;late endosome#GO:0005770;late endosome membrane#GO:0031902;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;lytic vacuole#GO:0000323;vacuolar membrane#GO:0005774 major histocompatibility complex protein#PC00149 T cell activation#P00053>MHC-antigen#P01316 HUMAN|HGNC=20796|UniProtKB=Q6ZTQ3 Q6ZTQ3 RASSF6 PTHR22738:SF3 RASSF RAS ASSOCIATION DOMAIN-CONTAINING PROTEIN 6 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;cell communication#GO:0007154 scaffold/adaptor protein#PC00226 HUMAN|HGNC=7158|UniProtKB=P39900 P39900 MMP12 PTHR10201:SF267 MATRIX METALLOPROTEINASE MACROPHAGE METALLOELASTASE hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metalloendopeptidase activity#GO:0004222;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 extracellular structure organization#GO:0043062;metabolic process#GO:0008152;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;external encapsulating structure organization#GO:0045229;cellular component organization#GO:0016043;cellular process#GO:0009987;catabolic process#GO:0009056 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 metalloprotease#PC00153 Alzheimer disease-presenilin pathway#P00004>Matrix metalloprotease#P00130 HUMAN|HGNC=10999|UniProtKB=Q9Y2P5 Q9Y2P5 SLC27A5 PTHR43107:SF25 LONG-CHAIN FATTY ACID TRANSPORT PROTEIN LONG-CHAIN FATTY ACID TRANSPORT PROTEIN 5 monocarboxylic acid transmembrane transporter activity#GO:0008028;transmembrane transporter activity#GO:0022857;ligase activity#GO:0016874;transporter activity#GO:0005215;catalytic activity#GO:0003824;carboxylic acid transmembrane transporter activity#GO:0046943;ATP-dependent activity#GO:0140657;ligase activity, forming carbon-sulfur bonds#GO:0016877 metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;carboxylic acid transport#GO:0046942;transport#GO:0006810;lipid metabolic process#GO:0006629;organic acid transport#GO:0015849;establishment of localization#GO:0051234;import into cell#GO:0098657;macromolecule localization#GO:0033036;long-chain fatty acid metabolic process#GO:0001676;cellular process#GO:0009987;lipid transport#GO:0006869;steroid metabolic process#GO:0008202;lipid localization#GO:0010876;oxoacid metabolic process#GO:0043436;fatty acid transport#GO:0015908;localization#GO:0051179;monocarboxylic acid transport#GO:0015718;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;small molecule metabolic process#GO:0044281 cell periphery#GO:0071944;membrane#GO:0016020;cytoplasm#GO:0005737;plasma membrane#GO:0005886;endomembrane system#GO:0012505;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227 secondary carrier transporter#PC00258 HUMAN|HGNC=1330|UniProtKB=Q9NPC6 Q9NPC6 MYOZ2 PTHR15941:SF9 MYOZENIN MYOZENIN-2 molecular condensate scaffold activity#GO:0140693;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;striated muscle tissue development#GO:0014706;cellular anatomical entity morphogenesis#GO:0032989;muscle organ development#GO:0007517;striated muscle cell differentiation#GO:0051146;anatomical structure formation involved in morphogenesis#GO:0048646;animal organ development#GO:0048513;cellular component organization or biogenesis#GO:0071840;muscle system process#GO:0003012;anatomical structure morphogenesis#GO:0009653;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;cell development#GO:0048468;actomyosin structure organization#GO:0031032;cell differentiation#GO:0030154;response to stimulus#GO:0050896;skeletal muscle organ development#GO:0060538;animal gross anatomical part developmental process#GO:0160108;striated muscle cell development#GO:0055002;skeletal muscle tissue development#GO:0007519;tissue development#GO:0009888;multicellular organismal process#GO:0032501;developmental process#GO:0032502;system process#GO:0003008;cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;myofibril assembly#GO:0030239;muscle cell differentiation#GO:0042692;muscle cell development#GO:0055001;actin cytoskeleton organization#GO:0030036;muscle structure development#GO:0061061;sarcomere organization#GO:0045214;actin filament-based process#GO:0030029;cellular component assembly involved in morphogenesis#GO:0010927;organelle assembly#GO:0070925;muscle tissue development#GO:0060537;supramolecular fiber organization#GO:0097435;anatomical structure development#GO:0048856 actin cytoskeleton#GO:0015629;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;myofibril#GO:0030016;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;Z disc#GO:0030018;contractile muscle fiber#GO:0043292;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;I band#GO:0031674;membraneless organelle#GO:0043228;sarcomere#GO:0030017 non-motor actin binding protein#PC00165;actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=20476|UniProtKB=Q9H596 Q9H596 DUSP21 PTHR46495:SF3 DUAL SPECIFICITY PROTEIN PHOSPHATASE 21 DUAL SPECIFICITY PROTEIN PHOSPHATASE 21 phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 protein phosphatase#PC00195 Oxidative stress response#P00046>MKP5#P01131 HUMAN|HGNC=16284|UniProtKB=Q9C019 Q9C019 TRIM15 PTHR24103:SF259 E3 UBIQUITIN-PROTEIN LIGASE TRIM E3 UBIQUITIN-PROTEIN LIGASE TRIM15 ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740 defense response#GO:0006952;response to external stimulus#GO:0009605;innate immune response#GO:0045087;immune system process#GO:0002376;response to other organism#GO:0051707;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;defense response to other organism#GO:0098542;response to stimulus#GO:0050896;defense response to symbiont#GO:0140546;immune response#GO:0006955;response to stress#GO:0006950;response to biotic stimulus#GO:0009607 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=2388|UniProtKB=P02489 P02489 CRYAA PTHR45640:SF14 HEAT SHOCK PROTEIN HSP-12.2-RELATED ALPHA-CRYSTALLIN A CHAIN system development#GO:0048731;protein metabolic process#GO:0019538;anatomical structure development#GO:0048856;camera-type eye development#GO:0043010;visual system development#GO:0150063;regulation of cellular process#GO:0050794;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;sensory organ development#GO:0007423;biological regulation#GO:0065007;biosynthetic process#GO:0009058;multicellular organismal process#GO:0032501;negative regulation of apoptotic process#GO:0043066;macromolecule biosynthetic process#GO:0009059;eye development#GO:0001654;protein refolding#GO:0042026;animal gross anatomical part developmental process#GO:0160108;protein folding#GO:0006457;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;response to abiotic stimulus#GO:0009628;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;animal organ development#GO:0048513;multicellular organism development#GO:0007275;regulation of apoptotic process#GO:0042981;lens development in camera-type eye#GO:0002088;metabolic process#GO:0008152;response to temperature stimulus#GO:0009266;gene expression#GO:0010467;protein maturation#GO:0051604;cellular process#GO:0009987;negative regulation of programmed cell death#GO:0043069;sensory system development#GO:0048880;response to stress#GO:0006950;response to heat#GO:0009408 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 chaperone#PC00072 VEGF signaling pathway#P00056>HSP27#P01412;Angiogenesis#P00005>HSP27#P00231 HUMAN|HGNC=11366|UniProtKB=P42229 P42229 STAT5A PTHR11801:SF47 SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;response to hormone#GO:0009725;response to stress#GO:0006950;response to chemokine#GO:1990868;cell surface receptor signaling pathway via STAT#GO:0097696;interleukin-15-mediated signaling pathway#GO:0035723;interleukin-9-mediated signaling pathway#GO:0038113;response to cytokine#GO:0034097;response to chemical#GO:0042221;cell surface receptor signaling pathway#GO:0007166;interleukin-7-mediated signaling pathway#GO:0038111;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;signaling#GO:0023052;cellular response to hormone stimulus#GO:0032870;regulation of transcription by RNA polymerase II#GO:0006357;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;response to oxygen-containing compound#GO:1901700;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;response to peptide#GO:1901652;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;response to peptide hormone#GO:0043434;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;cellular response to nitrogen compound#GO:1901699;regulation of nucleobase-containing compound metabolic process#GO:0019219;cell surface receptor signaling pathway via JAK-STAT#GO:0007259;defense response#GO:0006952;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular response to stimulus#GO:0051716;interleukin-2-mediated signaling pathway#GO:0038110;cellular response to peptide hormone stimulus#GO:0071375;cellular response to chemokine#GO:1990869;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cytokine-mediated signaling pathway#GO:0019221;regulation of RNA metabolic process#GO:0051252;response to nitrogen compound#GO:1901698;regulation of DNA-templated transcription#GO:0006355;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;chemokine-mediated signaling pathway#GO:0070098;regulation of cell population proliferation#GO:0042127 nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513 Rel homology transcription factor#PC00252;immunoglobulin fold transcription factor#PC00251 Interleukin signaling pathway#P00036>STAT#P00996;EGF receptor signaling pathway#P00018>STAT#P00561;PDGF signaling pathway#P00047>STAT#P01173;JAK/STAT signaling pathway#P00038>STAT#P01027 HUMAN|HGNC=9022|UniProtKB=P55347 P55347 PKNOX1 PTHR11850:SF80 HOMEOBOX PROTEIN TRANSCRIPTION FACTORS HOMEOBOX PROTEIN PKNOX1 DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;anatomical structure formation involved in morphogenesis#GO:0048646;vasculature development#GO:0001944;multicellular organism development#GO:0007275;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of transcription by RNA polymerase II#GO:0006357;circulatory system development#GO:0072359;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;blood vessel morphogenesis#GO:0048514;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;angiogenesis#GO:0001525;animal gross anatomical part developmental process#GO:0160108;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;tube development#GO:0035295;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;multicellular organismal process#GO:0032501;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;blood vessel development#GO:0001568;tube morphogenesis#GO:0035239;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 Gonadotropin-releasing hormone receptor pathway#P06664>Prep1#P06829 HUMAN|HGNC=9971|UniProtKB=P40938 P40938 RFC3 PTHR11669:SF1 REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT REPLICATION FACTOR C SUBUNIT 3 ATP-dependent activity#GO:0140657;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;catalytic activity, acting on DNA#GO:0140097;ATP-dependent activity, acting on DNA#GO:0008094 DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;DNA damage response#GO:0006974;cellular response to stress#GO:0033554;macromolecule metabolic process#GO:0043170;DNA-templated DNA replication#GO:0006261;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;DNA replication#GO:0006260;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694;nucleus#GO:0005634;replication fork#GO:0005657;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 DNA-directed DNA polymerase#PC00018 DNA replication#P00017>RFC#P00529 HUMAN|HGNC=6997|UniProtKB=Q14814 Q14814 MEF2D PTHR11945:SF23 MADS BOX PROTEIN MYOCYTE-SPECIFIC ENHANCER FACTOR 2D DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;positive regulation of transcription by RNA polymerase II#GO:0045944;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 MADS box transcription factor#PC00250 p38 MAPK pathway#P05918>MEF#P06023;CCKR signaling map#P06959>MEF2#P07032;CCKR signaling map#P06959>MEF2D#P07048 HUMAN|HGNC=17495|UniProtKB=Q8NFK1 Q8NFK1 GJC3 PTHR11984:SF56 CONNEXIN GAP JUNCTION GAMMA-3 PROTEIN transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;channel activity#GO:0015267;wide pore channel activity#GO:0022829 regulation of biological process#GO:0050789;cellular process#GO:0009987;signaling#GO:0023052;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;cell communication#GO:0007154 anchoring junction#GO:0070161;cell junction#GO:0030054;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;cell-cell junction#GO:0005911;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 gap junction#PC00105;cell junction protein#PC00070 HUMAN|HGNC=20595|UniProtKB=Q5JR59 Q5JR59 MTUS2 PTHR24200:SF14 TOUCAN, ISOFORM A MICROTUBULE-ASSOCIATED TUMOR SUPPRESSOR CANDIDATE 2 tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;microtubule binding#GO:0008017;protein binding#GO:0005515 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 HUMAN|HGNC=20980|UniProtKB=Q6UXK5 Q6UXK5 LRRN1 PTHR24373:SF97 SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN LEUCINE-RICH REPEAT NEURONAL PROTEIN 1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=5258|UniProtKB=P08238 P08238 HSP90AB1 PTHR11528:SF79 HEAT SHOCK PROTEIN 90 FAMILY MEMBER HEAT SHOCK PROTEIN HSP 90-BETA-RELATED pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;ATP hydrolysis activity#GO:0016887;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;ATP-dependent activity#GO:0140657;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP binding#GO:0005524;binding#GO:0005488 macromolecule metabolic process#GO:0043170;protein stabilization#GO:0050821;metabolic process#GO:0008152;protein maturation#GO:0051604;gene expression#GO:0010467;biological regulation#GO:0065007;biosynthetic process#GO:0009058;response to temperature stimulus#GO:0009266;response to stress#GO:0006950;cellular response to heat#GO:0034605;response to heat#GO:0009408;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;regulation of protein stability#GO:0031647;protein metabolic process#GO:0019538;regulation of biological quality#GO:0065008;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;protein folding#GO:0006457;primary metabolic process#GO:0044238;response to abiotic stimulus#GO:0009628;cellular response to stimulus#GO:0051716 cell periphery#GO:0071944;cytosol#GO:0005829;membrane#GO:0016020;perinuclear region of cytoplasm#GO:0048471;plasma membrane#GO:0005886;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622 Hsp90 family chaperone#PC00028;chaperone#PC00072 HUMAN|HGNC=18119|UniProtKB=Q8NB90 Q8NB90 AFG2A PTHR23077:SF27 AAA-FAMILY ATPASE ATPASE FAMILY GENE 2 PROTEIN HOMOLOG A pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP-dependent activity#GO:0140657;hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887 ribonucleoprotein complex biogenesis#GO:0022613;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;ribosome biogenesis#GO:0042254;ribosomal large subunit biogenesis#GO:0042273;cellular component biogenesis#GO:0044085 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 primary active transporter#PC00068;transporter#PC00227 HUMAN|HGNC=17344|UniProtKB=O60287 O60287 URB1 PTHR13500:SF0 NUCLEOLAR PRERIBOSOMAL-ASSOCIATED PROTEIN 1 NUCLEOLAR PRE-RIBOSOMAL-ASSOCIATED PROTEIN 1 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;ribonucleoprotein complex biogenesis#GO:0022613;maturation of 5.8S rRNA#GO:0000460;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;ribosomal large subunit biogenesis#GO:0042273;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;maturation of LSU-rRNA#GO:0000470;gene expression#GO:0010467;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840 nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232 HUMAN|HGNC=7207|UniProtKB=O75352 O75352 MPDU1 PTHR12226:SF5 MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 LEC35 -RELATED MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 PROTEIN carbohydrate metabolic process#GO:0005975;biosynthetic process#GO:0009058;carbohydrate biosynthetic process#GO:0016051;cellular process#GO:0009987;primary metabolic process#GO:0044238;oligosaccharide metabolic process#GO:0009311;oligosaccharide biosynthetic process#GO:0009312;metabolic process#GO:0008152 HUMAN|HGNC=21614|UniProtKB=Q9GZU7 Q9GZU7 CTDSP1 PTHR12210:SF139 DULLARD PROTEIN PHOSPHATASE CARBOXY-TERMINAL DOMAIN RNA POLYMERASE II POLYPEPTIDE A SMALL PHOSPHATASE 1 hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721;protein serine/threonine phosphatase activity#GO:0004722;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788 protein phosphatase#PC00195 HUMAN|HGNC=26267|UniProtKB=Q9H5K3 Q9H5K3 POMK PTHR22618:SF2 PROTEIN O-MANNOSE KINASE PROTEIN O-MANNOSE KINASE transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;carbohydrate kinase activity#GO:0019200;phosphotransferase activity, alcohol group as acceptor#GO:0016773 macromolecule biosynthetic process#GO:0009059;protein O-linked glycosylation#GO:0006493;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;biosynthetic process#GO:0009058;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;endoplasmic reticulum membrane#GO:0005789;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783 HUMAN|HGNC=1528|UniProtKB=P51636 P51636 CAV2 PTHR10844:SF3 CAVEOLIN CAVEOLIN-2 kinase binding#GO:0019900;binding#GO:0005488;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;protein binding#GO:0005515 developmental process#GO:0032502;monoatomic cation homeostasis#GO:0055080;cellular response to insulin stimulus#GO:0032869;intracellular monoatomic cation homeostasis#GO:0030003;negative regulation of cellular process#GO:0048523;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;cellular developmental process#GO:0048869;negative regulation of cell population proliferation#GO:0008285;biological regulation#GO:0065007;membrane organization#GO:0061024;response to peptide hormone#GO:0043434;cellular response to nitrogen compound#GO:1901699;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;response to nitrogen compound#GO:1901698;regulation of cell population proliferation#GO:0042127;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of cytosolic calcium ion concentration#GO:0051480;response to insulin#GO:0032868;cellular response to stimulus#GO:0051716;homeostatic process#GO:0042592;cellular response to peptide hormone stimulus#GO:0071375;regulation of cellular process#GO:0050794;chemical homeostasis#GO:0048878;cell surface receptor signaling pathway#GO:0007166;intracellular calcium ion homeostasis#GO:0006874;cellular component organization or biogenesis#GO:0071840;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;monoatomic ion homeostasis#GO:0050801;response to hormone#GO:0009725;endomembrane system organization#GO:0010256;response to chemical#GO:0042221;cellular component assembly#GO:0022607;insulin receptor signaling pathway#GO:0008286;response to oxygen-containing compound#GO:1901700;inorganic ion homeostasis#GO:0098771;cellular response to chemical stimulus#GO:0070887;calcium ion homeostasis#GO:0055074;plasma membrane organization#GO:0007009;regulation of biological process#GO:0050789;membrane assembly#GO:0071709;intracellular monoatomic ion homeostasis#GO:0006873;negative regulation of biological process#GO:0048519;response to endogenous stimulus#GO:0009719;cellular component organization#GO:0016043;signaling#GO:0023052;response to stimulus#GO:0050896;cell differentiation#GO:0030154;cellular response to endogenous stimulus#GO:0071495;cellular response to hormone stimulus#GO:0032870 cell periphery#GO:0071944;membrane#GO:0016020;caveola#GO:0005901;plasma membrane#GO:0005886;perinuclear region of cytoplasm#GO:0048471;cytoplasm#GO:0005737;plasma membrane region#GO:0098590;endomembrane system#GO:0012505;membrane microdomain#GO:0098857;Golgi apparatus#GO:0005794;cell junction#GO:0030054;sarcolemma#GO:0042383;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane raft#GO:0045121;cell-substrate junction#GO:0030055;focal adhesion#GO:0005925;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;anchoring junction#GO:0070161;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;plasma membrane raft#GO:0044853 scaffold/adaptor protein#PC00226 HUMAN|HGNC=18863|UniProtKB=Q9NS40 Q9NS40 KCNH7 PTHR10217:SF466 VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL VOLTAGE-GATED INWARDLY RECTIFYING POTASSIUM CHANNEL KCNH7 ligand-gated monoatomic ion channel activity#GO:0015276;potassium channel activity#GO:0005267;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;monoatomic cation channel activity#GO:0005261;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216 transport#GO:0006810;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;regulation of membrane potential#GO:0042391;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;cellular process#GO:0009987;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133;transporter#PC00227 HUMAN|HGNC=7613|UniProtKB=P52179 P52179 MYOM1 PTHR13817:SF16 TITIN MYOMESIN-1 structural molecule activity#GO:0005198;protein binding#GO:0005515;enzyme binding#GO:0019899;binding#GO:0005488;kinase binding#GO:0019900 anatomical structure formation involved in morphogenesis#GO:0048646;striated muscle cell differentiation#GO:0051146;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;developmental process#GO:0032502;cellular anatomical entity morphogenesis#GO:0032989;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;anatomical structure development#GO:0048856;striated muscle cell development#GO:0055002;sarcomere organization#GO:0045214;actin filament-based process#GO:0030029;cellular component assembly involved in morphogenesis#GO:0010927;animal gross anatomical part developmental process#GO:0160108;organelle assembly#GO:0070925;cell development#GO:0048468;actomyosin structure organization#GO:0031032;muscle structure development#GO:0061061;actin cytoskeleton organization#GO:0030036;cell differentiation#GO:0030154;myofibril assembly#GO:0030239;anatomical structure morphogenesis#GO:0009653;muscle cell differentiation#GO:0042692;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;muscle cell development#GO:0055001 supramolecular complex#GO:0099080;organelle#GO:0043226;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;A band#GO:0031672;contractile muscle fiber#GO:0043292;sarcomere#GO:0030017;membraneless organelle#GO:0043228;myofibril#GO:0030016;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;M band#GO:0031430;intracellular organelle#GO:0043229 structural protein#PC00211 HUMAN|HGNC=4227|UniProtKB=P50395 P50395 GDI2 PTHR11787:SF1 RAB GDP-DISSOCIATION INHIBITOR RAB GDP DISSOCIATION INHIBITOR BETA enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function regulator activity#GO:0098772 localization#GO:0051179;establishment of localization#GO:0051234;vesicle-mediated transport#GO:0016192;transport#GO:0006810;cellular process#GO:0009987 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HUMAN|HGNC=14995|UniProtKB=Q8NGY0 Q8NGY0 OR10X1 PTHR24242:SF264 G-PROTEIN COUPLED RECEPTOR OLFACTORY RECEPTOR 10X1 G-protein coupled receptor#PC00021 HUMAN|HGNC=16018|UniProtKB=Q86UW7 Q86UW7 CADPS2 PTHR12166:SF7 CALCIUM-DEPENDENT SECRETION ACTIVATOR CALCIUM-DEPENDENT SECRETION ACTIVATOR 2 establishment of localization#GO:0051234;regulation of localization#GO:0032879;regulation of transport#GO:0051049;exocytosis#GO:0006887;transport#GO:0006810;vesicle-mediated transport#GO:0016192;biological regulation#GO:0065007;positive regulation of transport#GO:0051050;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of secretion by cell#GO:1903532;cellular process#GO:0009987;localization#GO:0051179;regulation of secretion#GO:0051046;secretion#GO:0046903;secretion by cell#GO:0032940;regulation of secretion by cell#GO:1903530;regulation of exocytosis#GO:0017157;positive regulation of secretion#GO:0051047;regulation of cellular process#GO:0050794;export from cell#GO:0140352;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627 glutamatergic synapse#GO:0098978;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell junction#GO:0030054 membrane traffic protein#PC00150;membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=29443|UniProtKB=Q8N4N8 Q8N4N8 KIF2B PTHR24115:SF524 KINESIN-RELATED KINESIN-LIKE PROTEIN KIF2B hydrolase activity, acting on acid anhydrides#GO:0016817;cytoskeletal protein binding#GO:0008092;cytoskeletal motor activity#GO:0003774;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;ATP-dependent activity#GO:0140657;protein binding#GO:0005515;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;tubulin binding#GO:0015631;macromolecular conformation isomerase activity#GO:0120543;isomerase activity#GO:0016853;ribonucleoside triphosphate phosphatase activity#GO:0017111;microtubule binding#GO:0008017;polypeptide conformation or assembly isomerase activity#GO:0120544;hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887;microtubule motor activity#GO:0003777 microtubule-based process#GO:0007017;cilium organization#GO:0044782;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection assembly#GO:0120031;organelle assembly#GO:0070925;plasma membrane bounded cell projection organization#GO:0120036;microtubule-based movement#GO:0007018;cellular component assembly#GO:0022607;cell projection organization#GO:0030030;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996 polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;spindle#GO:0005819;microtubule organizing center#GO:0005815;centrosome#GO:0005813;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;microtubule associated complex#GO:0005875;microtubule cytoskeleton#GO:0015630;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=11943|UniProtKB=P63316 P63316 TNNC1 PTHR23064:SF47 TROPONIN TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES cytoskeletal protein binding#GO:0008092;cation binding#GO:0043169;metal ion binding#GO:0046872;protein binding#GO:0005515;calcium ion binding#GO:0005509;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167 heart process#GO:0003015;muscle system process#GO:0003012;multicellular organismal process#GO:0032501;blood circulation#GO:0008015;skeletal muscle contraction#GO:0003009;striated muscle contraction#GO:0006941;circulatory system process#GO:0003013;nervous system process#GO:0050877;muscle contraction#GO:0006936;cardiac muscle contraction#GO:0060048;neuromuscular process#GO:0050905;heart contraction#GO:0060047;system process#GO:0003008 cellular anatomical structure#GO:0110165;organelle#GO:0043226;actin cytoskeleton#GO:0015629;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;myofibril#GO:0030016;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;contractile muscle fiber#GO:0043292;membraneless organelle#GO:0043228;sarcomere#GO:0030017;cytoskeleton#GO:0005856 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=15134|UniProtKB=Q8NGQ4 Q8NGQ4 OR10Q1 PTHR26452:SF253 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 10Q1 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 sensory perception of chemical stimulus#GO:0007606;sensory perception#GO:0007600;nervous system process#GO:0050877;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;system process#GO:0003008 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=3801|UniProtKB=Q99958 Q99958 FOXC2 PTHR11829:SF189 FORKHEAD BOX PROTEIN FORKHEAD BOX PROTEIN C2 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;developmental process#GO:0032502;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 winged helix/forkhead transcription factor#PC00246;gene-specific transcriptional regulator#PC00264;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=26952|UniProtKB=P0DN77 P0DN77 OPN1MW2 PTHR24240:SF17 OPSIN MEDIUM-WAVE-SENSITIVE OPSIN 1-RELATED transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089 response to radiation#GO:0009314;cellular process#GO:0009987;cellular response to light stimulus#GO:0071482;signal transduction#GO:0007165;detection of stimulus#GO:0051606;biological regulation#GO:0065007;response to external stimulus#GO:0009605;cellular response to abiotic stimulus#GO:0071214;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;response to abiotic stimulus#GO:0009628;signaling#GO:0023052;cellular response to radiation#GO:0071478;cellular response to environmental stimulus#GO:0104004;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;response to light stimulus#GO:0009416;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 non-motile cilium#GO:0097730;membrane-bounded organelle#GO:0043227;cilium#GO:0005929;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;photoreceptor outer segment#GO:0001750;organelle#GO:0043226;photoreceptor cell cilium#GO:0097733;cell periphery#GO:0071944;neuron projection#GO:0043005;membrane#GO:0016020;9+0 non-motile cilium#GO:0097731 G-protein coupled receptor#PC00021 HUMAN|HGNC=15550|UniProtKB=Q4LE39 Q4LE39 ARID4B PTHR13964:SF24 RBP-RELATED AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 4B nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 transcription cofactor#PC00217 HUMAN|HGNC=19288|UniProtKB=Q8TDX5 Q8TDX5 ACMSD PTHR21240:SF27 2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE 2-AMINO-3-CARBOXYMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE lyase activity#GO:0016829;carbon-carbon lyase activity#GO:0016830;catalytic activity#GO:0003824;carboxy-lyase activity#GO:0016831 cellular process#GO:0009987;metabolic process#GO:0008152;secondary metabolic process#GO:0019748 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 decarboxylase#PC00089;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=2712|UniProtKB=Q13561 Q13561 DCTN2 PTHR15346:SF0 DYNACTIN SUBUNIT DYNACTIN SUBUNIT 2 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;cytoskeletal adaptor activity#GO:0008093;protein-membrane adaptor activity#GO:0043495 mitotic cell cycle#GO:0000278;microtubule-based movement#GO:0007018;establishment of organelle localization#GO:0051656;mitotic spindle organization#GO:0007052;nuclear migration#GO:0007097;cell cycle process#GO:0022402;cell cycle#GO:0007049;cellular component organization#GO:0016043;microtubule cytoskeleton organization involved in mitosis#GO:1902850;localization#GO:0051179;microtubule cytoskeleton organization#GO:0000226;cellular localization#GO:0051641;microtubule-based transport#GO:0099111;organelle localization#GO:0051640;cytoskeleton organization#GO:0007010;organelle transport along microtubule#GO:0072384;cytoskeleton-dependent intracellular transport#GO:0030705;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle organization#GO:0006996;mitotic cell cycle process#GO:1903047;microtubule-based process#GO:0007017;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;transport#GO:0006810;intracellular transport#GO:0046907 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;centrosome#GO:0005813;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;actin cytoskeleton#GO:0015629;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;microtubule associated complex#GO:0005875;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226 cytoskeletal protein#PC00085;microtubule binding motor protein#PC00156 HUMAN|HGNC=15517|UniProtKB=Q9H1B5 Q9H1B5 XYLT2 PTHR46025:SF1 XYLOSYLTRANSFERASE OXT XYLOSYLTRANSFERASE 2 glycosyltransferase activity#GO:0016757;catalytic activity, acting on a protein#GO:0140096;UDP-glycosyltransferase activity#GO:0008194;transferase activity#GO:0016740;catalytic activity#GO:0003824;UDP-xylosyltransferase activity#GO:0035252;xylosyltransferase activity#GO:0042285;pentosyltransferase activity#GO:0016763 primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;glycoprotein biosynthetic process#GO:0009101;protein O-linked glycosylation#GO:0006493;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;chondroitin sulfate proteoglycan metabolic process#GO:0050654;carbohydrate derivative metabolic process#GO:1901135;chondroitin sulfate proteoglycan biosynthetic process#GO:0050650;biosynthetic process#GO:0009058;proteoglycan biosynthetic process#GO:0030166;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;proteoglycan metabolic process#GO:0006029 transferase#PC00220 HUMAN|HGNC=19687|UniProtKB=Q9P2K8 Q9P2K8 EIF2AK4 PTHR11042:SF202 EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED EIF-2-ALPHA KINASE GCN2 protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096 cellular process#GO:0009987;regulation of protein metabolic process#GO:0051246;response to stress#GO:0006950;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular response to amino acid starvation#GO:0034198;regulation of translational initiation#GO:0006446;negative regulation of translation#GO:0017148;cellular response to stress#GO:0033554;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;response to stimulus#GO:0050896;cellular response to nutrient levels#GO:0031669;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;cellular response to starvation#GO:0009267;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;response to nutrient levels#GO:0031667;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;cellular response to stimulus#GO:0051716;response to starvation#GO:0042594;negative regulation of protein metabolic process#GO:0051248;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=30862|UniProtKB=O14957 O14957 UQCR11 PTHR15420:SF2 UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 6.4 KD PROTEIN CYTOCHROME B-C1 COMPLEX SUBUNIT 10 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 oxidoreductase#PC00176;reductase#PC00198 HUMAN|HGNC=12479|UniProtKB=Q969T4 Q969T4 UBE2E3 PTHR24068:SF63 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2 E3 acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein conjugating enzyme activity#GO:0061650;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin conjugating enzyme activity#GO:0061631;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein K11-linked ubiquitination#GO:0070979;cellular process#GO:0009987;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;protein K63-linked ubiquitination#GO:0070534;protein K48-linked ubiquitination#GO:0070936;metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 ubiquitin-protein ligase#PC00234 Ubiquitin proteasome pathway#P00060>E2#P01491 HUMAN|HGNC=21883|UniProtKB=Q9H3E2 Q9H3E2 SNX25 PTHR22775:SF48 SORTING NEXIN SORTING NEXIN-25 ion binding#GO:0043167;phosphatidylinositol binding#GO:0035091;small molecule binding#GO:0036094;anion binding#GO:0043168;binding#GO:0005488 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular vesicle#GO:0097708;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;intracellular organelle#GO:0043229 scaffold/adaptor protein#PC00226 HUMAN|HGNC=44448|UniProtKB=D6RJB6 D6RJB6 USP17L20 PTHR24006:SF651 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE INACTIVE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 17-LIKE PROTEIN 4-RELATED cysteine-type deubiquitinase activity#GO:0004843;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787 regulation of biological quality#GO:0065008;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of apoptotic process#GO:0042981;regulation of biological process#GO:0050789;regulation of protein stability#GO:0031647;regulation of programmed cell death#GO:0043067 nucleus#GO:0005634;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 protease#PC00190;cysteine protease#PC00081 HUMAN|HGNC=3176|UniProtKB=P05305 P05305 EDN1 PTHR13874:SF10 ENDOTHELIN ENDOTHELIN-1 neuropeptide receptor binding#GO:0071855;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;G protein-coupled receptor binding#GO:0001664;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;binding#GO:0005488;signaling receptor binding#GO:0005102;protein binding#GO:0005515;hormone activity#GO:0005179;molecular function activator activity#GO:0140677 regulation of biological quality#GO:0065008;inorganic ion homeostasis#GO:0098771;regulation of muscle contraction#GO:0006937;circulatory system process#GO:0003013;calcium ion homeostasis#GO:0055074;homeostatic process#GO:0042592;muscle system process#GO:0003012;regulation of biological process#GO:0050789;positive regulation of multicellular organismal process#GO:0051240;intracellular monoatomic ion homeostasis#GO:0006873;regulation of muscle system process#GO:0090257;system process#GO:0003008;intracellular calcium ion homeostasis#GO:0006874;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;regulation of smooth muscle contraction#GO:0006940;muscle contraction#GO:0006936;chemical homeostasis#GO:0048878;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;regulation of anatomical structure size#GO:0090066;regulation of system process#GO:0044057;biological regulation#GO:0065007;regulation of multicellular organismal process#GO:0051239;blood circulation#GO:0008015;multicellular organismal process#GO:0032501;positive regulation of biological process#GO:0048518;regulation of blood pressure#GO:0008217;monoatomic ion homeostasis#GO:0050801;regulation of systemic arterial blood pressure#GO:0003073 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 peptide hormone#PC00179 Wnt signaling pathway#P00057>NFAT Target Genes#G01559;Endothelin signaling pathway#P00019>Pre-pro ET1-4#P00576;Endothelin signaling pathway#P00019>Big ET1-4#P00574;Endothelin signaling pathway#P00019>Pro ET1-4#P00571;Endothelin signaling pathway#P00019>ET1-4#P00588 HUMAN|HGNC=12240|UniProtKB=A0A1B0GX31 A0A1B0GX31 TRBV7-6 PTHR23268:SF20 T-CELL RECEPTOR BETA CHAIN T CELL RECEPTOR BETA VARIABLE 7-4-RELATED cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=10662|UniProtKB=O00560 O00560 SDCBP PTHR12345:SF10 SYNTENIN RELATED SYNTENIN-1 protein binding#GO:0005515;carbohydrate derivative binding#GO:0097367;binding#GO:0005488 positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;positive regulation of signal transduction#GO:0009967;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092;regulation of biological process#GO:0050789;regulation of transforming growth factor beta receptor signaling pathway#GO:0017015;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;positive regulation of response to stimulus#GO:0048584;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cellular response to growth factor stimulus#GO:0090287;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of response to stimulus#GO:0048583 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;membrane#GO:0016020;cell periphery#GO:0071944 membrane traffic protein#PC00150;membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=20575|UniProtKB=Q5TCH4 Q5TCH4 CYP4A22 PTHR24291:SF215 CYTOCHROME P450 FAMILY 4 CYTOCHROME P450 4A11-RELATED oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;monooxygenase activity#GO:0004497;catalytic activity#GO:0003824 fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;developmental process#GO:0032502;unsaturated fatty acid metabolic process#GO:0033559;animal organ development#GO:0048513;multicellular organism development#GO:0007275;long-chain fatty acid metabolic process#GO:0001676;kidney development#GO:0001822;renal system development#GO:0072001;cellular process#GO:0009987;icosanoid metabolic process#GO:0006690;multicellular organismal process#GO:0032501;icosanoid biosynthetic process#GO:0046456;biosynthetic process#GO:0009058;animal gross anatomical part developmental process#GO:0160108;olefinic compound metabolic process#GO:0120254;oxoacid metabolic process#GO:0043436;anatomical structure development#GO:0048856;system development#GO:0048731;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;arachidonate metabolic process#GO:0019369;carboxylic acid biosynthetic process#GO:0046394;small molecule metabolic process#GO:0044281 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 oxygenase#PC00177;metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HUMAN|HGNC=5549|UniProtKB=A0A0C4DH31 A0A0C4DH31 IGHV1-18 PTHR23266:SF304 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 1-18 antigen binding#GO:0003823;binding#GO:0005488 immune response#GO:0006955;response to stimulus#GO:0050896;adaptive immune response#GO:0002250;immune system process#GO:0002376;immune effector process#GO:0002252;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;immunoglobulin mediated immune response#GO:0016064;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=10816|UniProtKB=P05408 P05408 SCG5 PTHR12738:SF0 NEUROENDOCRINE PROTEIN 7B2 NEUROENDOCRINE PROTEIN 7B2 enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 regulation of secretion#GO:0051046;regulation of hormone secretion#GO:0046883;regulation of localization#GO:0032879;regulation of transport#GO:0051049;regulation of biological quality#GO:0065008;regulation of secretion by cell#GO:1903530;regulation of signaling#GO:0023051;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;regulation of biological process#GO:0050789;regulation of hormone levels#GO:0010817 chaperone#PC00072 HUMAN|HGNC=11932|UniProtKB=Q9UNG2 Q9UNG2 TNFSF18 PTHR15267:SF1 TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 18 TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 18 cytokine receptor binding#GO:0005126;binding#GO:0005488;signaling receptor binding#GO:0005102;tumor necrosis factor receptor superfamily binding#GO:0032813;protein binding#GO:0005515 immune effector process#GO:0002252;cell surface receptor signaling pathway#GO:0007166;leukocyte activation involved in immune response#GO:0002366;positive regulation of response to external stimulus#GO:0032103;positive regulation of biological process#GO:0048518;lymphocyte activation involved in immune response#GO:0002285;signal transduction#GO:0007165;cellular process#GO:0009987;positive regulation of immune system process#GO:0002684;T cell activation involved in immune response#GO:0002286;response to chemical#GO:0042221;lymphocyte activation#GO:0046649;response to cytokine#GO:0034097;regulation of response to external stimulus#GO:0032101;immune system process#GO:0002376;T cell proliferation#GO:0042098;cell activation involved in immune response#GO:0002263;response to peptide#GO:1901652;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;positive regulation of cell motility#GO:2000147;regulation of chemotaxis#GO:0050920;T cell activation#GO:0042110;signaling#GO:0023052;response to stimulus#GO:0050896;mononuclear cell proliferation#GO:0032943;regulation of cell migration#GO:0030334;regulation of response to stimulus#GO:0048583;positive regulation of locomotion#GO:0040017;leukocyte proliferation#GO:0070661;positive regulation of cellular process#GO:0048522;immune response#GO:0006955;positive regulation of cell migration#GO:0030335;response to tumor necrosis factor#GO:0034612;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;positive regulation of response to stimulus#GO:0048584;lymphocyte proliferation#GO:0046651;multicellular organismal process#GO:0032501;regulation of granulocyte chemotaxis#GO:0071622;cell population proliferation#GO:0008283;cell activation#GO:0001775;cytokine-mediated signaling pathway#GO:0019221;cell communication#GO:0007154;regulation of cell motility#GO:2000145;tumor necrosis factor-mediated signaling pathway#GO:0033209;positive regulation of chemotaxis#GO:0050921;cellular response to stimulus#GO:0051716;leukocyte activation#GO:0045321;regulation of leukocyte migration#GO:0002685;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;cell surface#GO:0009986 intercellular signal molecule#PC00207 HUMAN|HGNC=21738|UniProtKB=Q3MIX3 Q3MIX3 ADCK5 PTHR43173:SF28 ABC1 FAMILY PROTEIN AARF DOMAIN CONTAINING KINASE 5 primary active transporter#PC00068;transporter#PC00227;ATP-binding cassette (ABC) transporter#PC00003 HUMAN|HGNC=7694|UniProtKB=O14561 O14561 NDUFAB1 PTHR20863:SF80 ACYL CARRIER PROTEIN ACYL CARRIER PROTEIN, MITOCHONDRIAL molecular carrier activity#GO:0140104;small molecule binding#GO:0036094;binding#GO:0005488 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;mitochondrion#GO:0005739;transmembrane transporter complex#GO:1902495;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;membrane#GO:0016020;oxidoreductase complex#GO:1990204;respiratory chain complex#GO:0098803;transporter complex#GO:1990351;respiratory chain complex I#GO:0045271 transfer/carrier protein#PC00219 HUMAN|HGNC=29522|UniProtKB=Q99619 Q99619 SPSB2 PTHR12245:SF2 SPRY DOMAIN CONTAINING SOCS BOX PROTEIN SPRY DOMAIN-CONTAINING SOCS BOX PROTEIN 2 ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056 catalytic complex#GO:1902494;transferase complex#GO:1990234;ubiquitin ligase complex#GO:0000151;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;SCF ubiquitin ligase complex#GO:0019005;cytoplasm#GO:0005737;cullin-RING ubiquitin ligase complex#GO:0031461 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=206|UniProtKB=Q9UKQ2 Q9UKQ2 ADAM28 PTHR11905:SF32 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 28 metalloendopeptidase activity#GO:0004222;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 proteolysis#GO:0006508;metabolic process#GO:0008152;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 protease#PC00190;metalloprotease#PC00153 HUMAN|HGNC=14769|UniProtKB=Q8NGJ4 Q8NGJ4 OR52E2 PTHR26450:SF392 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 52E2 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=24326|UniProtKB=Q96DM3 Q96DM3 RMC1 PTHR12897:SF4 COLON CANCER-ASSOCIATED PROTEIN MIC1 REGULATOR OF MON1-CCZ1 COMPLEX structural molecule activity#GO:0005198;protein complex scaffold activity#GO:0140378 regulation of metabolic process#GO:0019222;regulation of autophagy#GO:0010506;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of catabolic process#GO:0009894;biological regulation#GO:0065007 intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;endosome membrane#GO:0010008;endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;vesicle membrane#GO:0012506;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;guanyl-nucleotide exchange factor complex#GO:0032045;late endosome#GO:0005770;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;late endosome membrane#GO:0031902;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular protein-containing complex#GO:0140535 HUMAN|HGNC=1463|UniProtKB=Q13555 Q13555 CAMK2G PTHR24347:SF398 SERINE/THREONINE-PROTEIN KINASE CALCIUM_CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT GAMMA catalytic activity, acting on a protein#GO:0140096;calmodulin binding#GO:0005516;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein binding#GO:0005515;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;binding#GO:0005488;calcium/calmodulin-dependent protein kinase activity#GO:0004683 regulation of cell communication#GO:0010646;modulation of chemical synaptic transmission#GO:0050804;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of biological process#GO:0050789;regulation of biological quality#GO:0065008;regulation of protein localization#GO:0032880;regulation of signaling#GO:0023051;biological regulation#GO:0065007;regulation of trans-synaptic signaling#GO:0099177;regulation of neuron projection development#GO:0010975;regulation of protein localization to membrane#GO:1905475;regulation of localization#GO:0032879;regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of neuronal synaptic plasticity#GO:0048168;regulation of cell projection organization#GO:0031344;regulation of synaptic plasticity#GO:0048167 asymmetric synapse#GO:0032279;postsynaptic specialization#GO:0099572;organelle#GO:0043226;cellular anatomical structure#GO:0110165;synapse#GO:0045202;neuron to neuron synapse#GO:0098984;cell projection#GO:0042995;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;postsynapse#GO:0098794;neuron projection#GO:0043005;cell junction#GO:0030054;intracellular anatomical structure#GO:0005622;axon#GO:0030424;postsynaptic density#GO:0014069 non-receptor serine/threonine protein kinase#PC00167 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CaMK#P00847;Ionotropic glutamate receptor pathway#P00037>CaMKII#P01023 HUMAN|HGNC=29435|UniProtKB=Q8IX03 Q8IX03 WWC1 PTHR14791:SF22 BOMB/KIRA PROTEINS PROTEIN KIBRA protein binding#GO:0005515;enzyme binding#GO:0019899;kinase binding#GO:0019900;binding#GO:0005488 regulation of nucleobase-containing compound metabolic process#GO:0019219;cell migration#GO:0016477;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of multicellular organismal process#GO:0051239;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;cellular process#GO:0009987;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of response to stimulus#GO:0048583;regulation of macromolecule metabolic process#GO:0060255;cell motility#GO:0048870;regulation of cellular process#GO:0050794;regulation of developmental process#GO:0050793;regulation of cell communication#GO:0010646;regulation of hippo signaling#GO:0035330;negative regulation of multicellular organismal process#GO:0051241;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of growth#GO:0040008;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=22229|UniProtKB=Q8NF64 Q8NF64 ZMIZ2 PTHR10782:SF38 ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN 2 ubiquitin-like protein ligase activity#GO:0061659;molecular function inhibitor activity#GO:0140678;SUMO transferase activity#GO:0019789;transcription regulator activity#GO:0140110;SUMO ligase activity#GO:0061665;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;molecular function regulator activity#GO:0098772;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transcription coactivator activity#GO:0003713;transferase activity#GO:0016740;catalytic activity#GO:0003824;transcription coregulator activity#GO:0003712 negative regulation of cellular process#GO:0048523;regulation of receptor signaling pathway via JAK-STAT#GO:0046425;regulation of response to stimulus#GO:0048583;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of response to stimulus#GO:0048585;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;post-translational protein modification#GO:0043687;regulation of DNA-templated transcription#GO:0006355;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;regulation of RNA metabolic process#GO:0051252;protein modification process#GO:0036211;primary metabolic process#GO:0044238;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of receptor signaling pathway via STAT#GO:1904892;metabolic process#GO:0008152;protein sumoylation#GO:0016925;cellular process#GO:0009987;negative regulation of signal transduction#GO:0009968;protein modification by small protein conjugation or removal#GO:0070647;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;protein modification by small protein conjugation#GO:0032446;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357 organelle lumen#GO:0043233;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;chromatin#GO:0000785;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=7437|UniProtKB=P49914 P49914 MTHFS PTHR23407:SF1 ATPASE INHIBITOR/5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE 5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE ligase activity, forming carbon-nitrogen bonds#GO:0016879;ligase activity#GO:0016874;catalytic activity#GO:0003824 tetrahydrofolate metabolic process#GO:0046653;metabolic process#GO:0008152;tetrahydrofolate biosynthetic process#GO:0046654;small molecule metabolic process#GO:0044281;folic acid-containing compound metabolic process#GO:0006760;pteridine-containing compound metabolic process#GO:0042558;biosynthetic process#GO:0009058;modified amino acid metabolic process#GO:0006575;cellular process#GO:0009987 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 ligase#PC00142 HUMAN|HGNC=28250|UniProtKB=Q6P1W5 Q6P1W5 C1orf94 PTHR35674:SF1 CDNA SEQUENCE CK137956 CDNA SEQUENCE CK137956 HUMAN|HGNC=677|UniProtKB=P85298 P85298 ARHGAP8 PTHR45808:SF4 RHO GTPASE-ACTIVATING PROTEIN 68F RHO GTPASE-ACTIVATING PROTEIN 8 enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695 intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of localization#GO:0032879;regulation of transport#GO:0051049;negative regulation of cellular process#GO:0048523;signaling#GO:0023052;regulation of cellular process#GO:0050794;negative regulation of transport#GO:0051051;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 VEGF signaling pathway#P00056>Rac#P01421;PDGF signaling pathway#P00047>Rho#P01174;Cytoskeletal regulation by Rho GTPase#P00016>Rho GAPs#P00520;Angiogenesis#P00005>Rac#P00245 HUMAN|HGNC=8652|UniProtKB=P57723 P57723 PCBP4 PTHR10288:SF166 KH DOMAIN CONTAINING RNA BINDING PROTEIN POLY(RC)-BINDING PROTEIN 4 nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;RNA binding#GO:0003723 negative regulation of biosynthetic process#GO:0009890;regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of mRNA processing#GO:0050684;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of mRNA metabolic process#GO:1903311;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of mRNA splicing, via spliceosome#GO:0048024;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 RNA metabolism protein#PC00031 HUMAN|HGNC=18280|UniProtKB=Q86XS8 Q86XS8 RNF130 PTHR22765:SF40 RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING E3 UBIQUITIN-PROTEIN LIGASE RNF130 catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842 programmed cell death#GO:0012501;cell death#GO:0008219;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=40028|UniProtKB=F5GYI3 F5GYI3 UBAP1L PTHR15960:SF3 LD44032P UBIQUITIN-ASSOCIATED PROTEIN 1-LIKE ubiquitin binding#GO:0043130;binding#GO:0005488;protein binding#GO:0005515 ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043162;catabolic process#GO:0009056;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238 intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;endosome membrane#GO:0010008;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;vesicle membrane#GO:0012506;membrane#GO:0016020;ESCRT I complex#GO:0000813;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;cytoplasm#GO:0005737;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588 HUMAN|HGNC=28507|UniProtKB=Q8NHP7 Q8NHP7 EXD1 PTHR46628:SF1 PIRNA BIOGENESIS PROTEIN EXD1 PIRNA BIOGENESIS PROTEIN EXD1 negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;gene expression#GO:0010467;RNA processing#GO:0006396;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;negative regulation of metabolic process#GO:0009892;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;macromolecule biosynthetic process#GO:0009059;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;negative regulation of cellular process#GO:0048523;regulatory ncRNA-mediated gene silencing#GO:0031047;regulatory ncRNA processing#GO:0070918;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;RNA biosynthetic process#GO:0032774;piRNA processing#GO:0034587 protein-containing complex#GO:0032991 HUMAN|HGNC=7861|UniProtKB=P40261 P40261 NNMT PTHR10867:SF52 NNMT/PNMT/TEMT FAMILY MEMBER NICOTINAMIDE N-METHYLTRANSFERASE N-methyltransferase activity#GO:0008170;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;transferase activity, transferring one-carbon groups#GO:0016741;methyltransferase activity#GO:0008168;catalytic activity#GO:0003824;transferase activity#GO:0016740 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 transferase#PC00220;methyltransferase#PC00155 Adrenaline and noradrenaline biosynthesis#P00001>PNMT#P00061 HUMAN|HGNC=1404|UniProtKB=O00305 O00305 CACNB4 PTHR11824:SF7 VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-4 trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;synaptic signaling#GO:0099536;chemical synaptic transmission#GO:0007268;cellular process#GO:0009987;regulation of biological process#GO:0050789;anterograde trans-synaptic signaling#GO:0098916;biological regulation#GO:0065007;signaling#GO:0023052;synaptic transmission, glutamatergic#GO:0035249;cell-cell signaling#GO:0007267 voltage-gated ion channel#PC00241 Thyrotropin-releasing hormone receptor signaling pathway#P04394>Ca2+ channel#P04587;Oxytocin receptor mediated signaling pathway#P04391>Ca2+ channel#P04535;Beta1 adrenergic receptor signaling pathway#P04377>Ca2+ channel#P04438;Beta2 adrenergic receptor signaling pathway#P04378>Ca2+ channel#P04445;5HT2 type receptor mediated signaling pathway#P04374>Ca2+ channel#P04411 HUMAN|HGNC=16011|UniProtKB=Q9Y576 Q9Y576 ASB1 PTHR24173:SF27 ANKYRIN REPEAT CONTAINING ANKYRIN REPEAT AND SOCS BOX PROTEIN 1 scaffold/adaptor protein#PC00226 HUMAN|HGNC=17113|UniProtKB=Q9NWT6 Q9NWT6 HIF1AN PTHR12461:SF108 HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;dioxygenase activity#GO:0051213;oxidoreductase activity#GO:0016491;catalytic activity, acting on a protein#GO:0140096;2-oxoglutarate-dependent dioxygenase activity#GO:0016706 negative regulation of Notch signaling pathway#GO:0045746;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;regulation of cellular response to growth factor stimulus#GO:0090287;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of signal transduction#GO:0009968;negative regulation of response to stimulus#GO:0048585;regulation of signaling#GO:0023051;regulation of Notch signaling pathway#GO:0008593;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794 nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HUMAN|HGNC=17326|UniProtKB=P02814 P02814 SMR3B PTHR14179:SF13 SMR1-RELATED SUBMAXILLARY GLAND ANDROGEN-REGULATED PROTEIN 3B protein-binding activity modulator#PC00095;protease inhibitor#PC00191 HUMAN|HGNC=14837|UniProtKB=Q8NGV0 Q8NGV0 OR2Y1 PTHR26453:SF303 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2Y1 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception#GO:0007600;nervous system process#GO:0050877;system process#GO:0003008;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;detection of chemical stimulus#GO:0009593;response to chemical#GO:0042221;response to stimulus#GO:0050896;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=21394|UniProtKB=Q9NQ25 Q9NQ25 SLAMF7 PTHR12080:SF46 SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE SLAM FAMILY MEMBER 7 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 leukocyte activation#GO:0045321;T cell activation#GO:0042110;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;immune system process#GO:0002376;cell activation#GO:0001775;cell communication#GO:0007154;signal transduction#GO:0007165;immune response#GO:0006955;cellular process#GO:0009987;lymphocyte activation#GO:0046649;multicellular organismal process#GO:0032501;biological regulation#GO:0065007 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=37096|UniProtKB=A6NI47 A6NI47 POTEM PTHR24118:SF56 POTE ANKYRIN DOMAIN POTE ANKYRIN DOMAIN FAMILY MEMBER G-RELATED transcription regulator activity#GO:0140110;transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712 regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of non-canonical NF-kappaB signal transduction#GO:1901222;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 membrane traffic protein#PC00150 HUMAN|HGNC=27949|UniProtKB=Q6ZQY3 Q6ZQY3 GADL1 PTHR45677:SF1 GLUTAMATE DECARBOXYLASE-RELATED ACIDIC AMINO ACID DECARBOXYLASE GADL1 lyase activity#GO:0016829;catalytic activity#GO:0003824;carboxy-lyase activity#GO:0016831;carbon-carbon lyase activity#GO:0016830 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;decarboxylase#PC00089 Gamma-aminobutyric acid synthesis#P04384>Glutamate decarboxylase#P04482 HUMAN|HGNC=1317|UniProtKB=P16383 P16383 GCFC2 PTHR12214:SF4 GC-RICH SEQUENCE DNA-BINDING FACTOR INTRON LARGE COMPLEX COMPONENT GCFC2 nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=5048|UniProtKB=Q00839 Q00839 HNRNPU PTHR12381:SF11 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN U FAMILY MEMBER HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN U RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;chromatin binding#GO:0003682 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;positive regulation of RNA metabolic process#GO:0051254;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;RNA splicing, via transesterification reactions#GO:0000375;regulation of RNA metabolic process#GO:0051252;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;macromolecule biosynthetic process#GO:0009059;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biosynthetic process#GO:0009058;positive regulation of RNA biosynthetic process#GO:1902680;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulation of biological process#GO:0050789;mRNA splicing, via spliceosome#GO:0000398;mRNA metabolic process#GO:0016071;regulation of transcription by RNA polymerase II#GO:0006357;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;mRNA processing#GO:0006397;RNA processing#GO:0006396;gene expression#GO:0010467;positive regulation of macromolecule metabolic process#GO:0010604;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;positive regulation of transcription by RNA polymerase II#GO:0045944;alternative mRNA splicing, via spliceosome#GO:0000380 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=403|UniProtKB=P51648 P51648 ALDH3A2 PTHR43570:SF9 ALDEHYDE DEHYDROGENASE ALDEHYDE DEHYDROGENASE FAMILY 3 MEMBER A2 catalytic activity#GO:0003824;oxidoreductase activity, acting on the aldehyde or oxo group of donors#GO:0016903;aldehyde dehydrogenase (NAD+) activity#GO:0004029;oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor#GO:0016620;oxidoreductase activity#GO:0016491 metabolic process#GO:0008152;cellular process#GO:0009987;aldehyde metabolic process#GO:0006081 membrane#GO:0016020;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 dehydrogenase#PC00092 5-Hydroxytryptamine degredation#P04372>Aldehyde Dehydrogenase#P04402 HUMAN|HGNC=3613|UniProtKB=P12314 P12314 FCGR1A PTHR11481:SF11 IMMUNOGLOBULIN FC RECEPTOR HIGH AFFINITY IMMUNOGLOBULIN GAMMA FC RECEPTOR I-RELATED transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 immune effector process#GO:0002252;cell surface receptor signaling pathway#GO:0007166;cellular process#GO:0009987;signal transduction#GO:0007165;immune response#GO:0006955;adaptive immune response#GO:0002250;biological regulation#GO:0065007;immune system process#GO:0002376;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=1004|UniProtKB=Q4VC05 Q4VC05 BCL7A PTHR12767:SF11 BCL7 RELATED B-CELL CLL_LYMPHOMA 7 PROTEIN FAMILY MEMBER A cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;Notch signaling pathway#GO:0007219;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;Wnt signaling pathway#GO:0016055;regulation of cellular process#GO:0050794 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ATPase complex#GO:1904949;intracellular organelle#GO:0043229;SWI/SNF complex#GO:0016514;catalytic complex#GO:1902494;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;SWI/SNF superfamily-type complex#GO:0070603;chromosome#GO:0005694;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;chromatin#GO:0000785;nucleus#GO:0005634 HUMAN|HGNC=3355|UniProtKB=Q07075 Q07075 ENPEP PTHR11533:SF276 PROTEASE M1 ZINC METALLOPROTEASE GLUTAMYL AMINOPEPTIDASE peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;metalloexopeptidase activity#GO:0008235;catalytic activity#GO:0003824;aminopeptidase activity#GO:0004177;exopeptidase activity#GO:0008238;hydrolase activity#GO:0016787;metalloaminopeptidase activity#GO:0070006;metallopeptidase activity#GO:0008237 proteolysis#GO:0006508;circulatory system process#GO:0003013;signaling receptor ligand precursor processing#GO:0140448;protein metabolic process#GO:0019538;peptide metabolic process#GO:0006518;regulation of biological quality#GO:0065008;primary metabolic process#GO:0044238;regulation of hormone levels#GO:0010817;catabolic process#GO:0009056;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;system process#GO:0003008;regulation of blood pressure#GO:0008217;regulation of systemic arterial blood pressure#GO:0003073;peptide catabolic process#GO:0043171;protein processing#GO:0016485;peptide hormone processing#GO:0016486;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;hormone metabolic process#GO:0042445;blood circulation#GO:0008015;multicellular organismal process#GO:0032501;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;biological regulation#GO:0065007 extracellular region#GO:0005576;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 protease#PC00190;metalloprotease#PC00153 HUMAN|HGNC=17378|UniProtKB=Q9UK23 Q9UK23 NAGPA PTHR40446:SF2 N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE protein localization to extracellular region#GO:0071692;cellular process#GO:0009987;establishment of protein localization#GO:0045184;macromolecule localization#GO:0033036;export from cell#GO:0140352;transport#GO:0006810;establishment of protein localization to extracellular region#GO:0035592;protein transport#GO:0015031;intracellular protein localization#GO:0008104;secretion by cell#GO:0032940;establishment of localization#GO:0051234;secretion#GO:0046903;localization#GO:0051179;protein secretion#GO:0009306 HUMAN|HGNC=5748|UniProtKB=P01601 P01601 IGKV1D-16 PTHR23267:SF460 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN KAPPA VARIABLE 1D-16 response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 protein-containing complex#GO:0032991 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=24856|UniProtKB=Q96A33 Q96A33 CCDC47 PTHR12883:SF0 ADIPOCYTE-SPECIFIC PROTEIN 4-RELATED PAT COMPLEX SUBUNIT CCDC47 localization within membrane#GO:0051668;localization#GO:0051179;cellular localization#GO:0051641;cellular component organization#GO:0016043;endoplasmic reticulum organization#GO:0007029;protein insertion into ER membrane#GO:0045048;protein localization to organelle#GO:0033365;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;establishment of protein localization to membrane#GO:0090150;macromolecule localization#GO:0033036;organelle organization#GO:0006996;establishment of protein localization#GO:0045184;cellular process#GO:0009987;protein insertion into membrane#GO:0051205;membrane organization#GO:0061024;endomembrane system organization#GO:0010256 organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;protein folding chaperone complex#GO:0101031;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;membrane#GO:0016020;intracellular protein-containing complex#GO:0140535;organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783 HUMAN|HGNC=28121|UniProtKB=Q5JSZ5 Q5JSZ5 PRRC2B PTHR14038:SF4 BAT2 HLA-B-ASSOCIATED TRANSCRIPT 2 PROTEIN PRRC2B RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031 HUMAN|HGNC=3466|UniProtKB=Q9NQ30 Q9NQ30 ESM1 PTHR15428:SF0 ENDOTHELIAL CELL-SPECIFIC MOLECULE 1 ESM-1 ENDOTHELIAL CELL-SPECIFIC MOLECULE 1 protein binding#GO:0005515;protein-containing complex binding#GO:0044877;integrin binding#GO:0005178;binding#GO:0005488;signaling receptor binding#GO:0005102;cell adhesion molecule binding#GO:0050839 sprouting angiogenesis#GO:0002040;animal gross anatomical part developmental process#GO:0160108;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;angiogenesis#GO:0001525;anatomical structure development#GO:0048856;system development#GO:0048731;positive regulation of signal transduction#GO:0009967;blood vessel morphogenesis#GO:0048514;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;blood vessel development#GO:0001568;tube morphogenesis#GO:0035239;circulatory system development#GO:0072359;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of cell communication#GO:0010646;developmental process#GO:0032502;regulation of response to stimulus#GO:0048583;multicellular organism development#GO:0007275;anatomical structure formation involved in morphogenesis#GO:0048646;vasculature development#GO:0001944;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of response to stimulus#GO:0048584;multicellular organismal process#GO:0032501;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;tube development#GO:0035295 HUMAN|HGNC=18940|UniProtKB=Q3LI72 Q3LI72 KRTAP19-5 PTHR38140:SF4 KERATIN-ASSOCIATED PROTEIN 19-3-RELATED KERATIN-ASSOCIATED PROTEIN 19-5 structural protein#PC00211 HUMAN|HGNC=4758|UniProtKB=P23527 P23527 H2BC17 PTHR23428:SF390 HISTONE H2B HISTONE H2B TYPE 1-O immune system process#GO:0002376;response to bacterium#GO:0009617;defense response to bacterium#GO:0042742;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;antimicrobial humoral response#GO:0019730;humoral immune response#GO:0006959;innate immune response#GO:0045087;antibacterial humoral response#GO:0019731;response to external stimulus#GO:0009605;defense response#GO:0006952;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;immune response#GO:0006955;defense response to symbiont#GO:0140546;defense response to other organism#GO:0098542;response to other organism#GO:0051707 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=4755|UniProtKB=Q93079 Q93079 H2BC9 PTHR23428:SF160 HISTONE H2B HISTONE H2B TYPE 1-H immune system process#GO:0002376;response to bacterium#GO:0009617;defense response to bacterium#GO:0042742;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;response to stimulus#GO:0050896;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;antimicrobial humoral response#GO:0019730;humoral immune response#GO:0006959;antibacterial humoral response#GO:0019731;innate immune response#GO:0045087;defense response#GO:0006952;response to external stimulus#GO:0009605;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;immune response#GO:0006955;defense response to symbiont#GO:0140546;defense response to other organism#GO:0098542;response to other organism#GO:0051707 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=13994|UniProtKB=Q9NQV7 Q9NQV7 PRDM9 PTHR16515:SF10 PR DOMAIN ZINC FINGER PROTEIN HISTONE-LYSINE N-METHYLTRANSFERASE PRDM9 histone H3K36 methyltransferase activity#GO:0046975;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741;lysine N-methyltransferase activity#GO:0016278;histone modifying activity#GO:0140993;histone methyltransferase activity#GO:0042054;protein-lysine N-methyltransferase activity#GO:0016279;binding#GO:0005488;methyltransferase activity#GO:0008168;catalytic activity, acting on a protein#GO:0140096;protein methyltransferase activity#GO:0008276;catalytic activity#GO:0003824;histone H3K4 methyltransferase activity#GO:0042800;histone H3 methyltransferase activity#GO:0140938;DNA binding#GO:0003677;N-methyltransferase activity#GO:0008170;nucleic acid binding#GO:0003676;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757 positive regulation of DNA metabolic process#GO:0051054;regulation of biological process#GO:0050789;regulation of meiotic cell cycle#GO:0051445;positive regulation of cell cycle process#GO:0090068;regulation of organelle organization#GO:0033043;regulation of DNA metabolic process#GO:0051052;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of cell cycle#GO:0051726;regulation of DNA recombination#GO:0000018;positive regulation of cellular component organization#GO:0051130;positive regulation of metabolic process#GO:0009893;positive regulation of organelle organization#GO:0010638;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of macromolecule metabolic process#GO:0010604;regulation of reproductive process#GO:2000241;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of cell cycle process#GO:0010564;positive regulation of cell cycle#GO:0045787;regulation of nuclear division#GO:0051783;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218;C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HUMAN|HGNC=10539|UniProtKB=Q12999 Q12999 TSPAN31 PTHR19282:SF3 TETRASPANIN TETRASPANIN-31 scaffold/adaptor protein#PC00226 HUMAN|HGNC=23385|UniProtKB=Q5JVG2 Q5JVG2 ZNF484 PTHR24376:SF277 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 484 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=21039|UniProtKB=Q6P9G9 Q6P9G9 ZNF449 PTHR23226:SF4 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER PROTEIN 449 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=1385|UniProtKB=Q9NPB3 Q9NPB3 CABP2 PTHR45917:SF2 CALCIUM-BINDING PROTEIN 1-RELATED CALCIUM-BINDING PROTEIN 2 transporter regulator activity#GO:0141108;calcium channel regulator activity#GO:0005246;ion channel regulator activity#GO:0099106;molecular function regulator activity#GO:0098772;channel regulator activity#GO:0016247 sensory perception#GO:0007600;sensory perception of mechanical stimulus#GO:0050954;nervous system process#GO:0050877;cell communication#GO:0007154;sensory perception of light stimulus#GO:0050953;response to abiotic stimulus#GO:0009628;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;sensory perception of sound#GO:0007605;response to light stimulus#GO:0009416;visual perception#GO:0007601;regulation of cellular process#GO:0050794;signaling#GO:0023052;system process#GO:0003008;response to external stimulus#GO:0009605;detection of stimulus#GO:0051606;signal transduction#GO:0007165;cellular process#GO:0009987;response to radiation#GO:0009314;multicellular organismal process#GO:0032501;biological regulation#GO:0065007 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=10026|UniProtKB=P04808 P04808 RLN1 PTHR12004:SF14 RELAXIN PRORELAXIN H1 peptide hormone#PC00179;intercellular signal molecule#PC00207 HUMAN|HGNC=1172|UniProtKB=Q9UID3 Q9UID3 VPS51 PTHR15954:SF4 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG establishment of localization in cell#GO:0051649;cellular process#GO:0009987;retrograde transport, endosome to Golgi#GO:0042147;organelle organization#GO:0006996;endomembrane system organization#GO:0010256;vesicle-mediated transport#GO:0016192;vacuolar transport#GO:0007034;Golgi vesicle transport#GO:0048193;transport#GO:0006810;intracellular transport#GO:0046907;vesicle-mediated transport to the plasma membrane#GO:0098876;endosomal transport#GO:0016197;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;Golgi organization#GO:0007030;cellular component organization#GO:0016043;cytosolic transport#GO:0016482;endocytic recycling#GO:0032456;localization within membrane#GO:0051668;localization#GO:0051179;cellular localization#GO:0051641 vesicle tethering complex#GO:0099023;Golgi apparatus#GO:0005794;recycling endosome#GO:0055037;cytoplasm#GO:0005737;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708 HUMAN|HGNC=1067|UniProtKB=P13497 P13497 BMP1 PTHR10127:SF863 DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING BONE MORPHOGENETIC PROTEIN 1 hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 macromolecule metabolic process#GO:0043170;multicellular organism development#GO:0007275;developmental process#GO:0032502;metabolic process#GO:0008152;biosynthetic process#GO:0009058;multicellular organismal process#GO:0032501;gene expression#GO:0010467;regionalization#GO:0003002;protein maturation#GO:0051604;cellular process#GO:0009987;protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059;anatomical structure development#GO:0048856;protein metabolic process#GO:0019538;pattern specification process#GO:0007389;proteolysis#GO:0006508;dorsal/ventral pattern formation#GO:0009953;primary metabolic process#GO:0044238 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease#PC00190;metalloprotease#PC00153 TGF-beta signaling pathway#P00052>TGFbeta#P01286 HUMAN|HGNC=2537|UniProtKB=P07711 P07711 CTSL PTHR12411:SF902 CYSTEINE PROTEASE FAMILY C1-RELATED PROCATHEPSIN L catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;cysteine-type endopeptidase activity#GO:0004197 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;catabolic process#GO:0009056;cellular process#GO:0009987;primary metabolic process#GO:0044238 intracellular organelle#GO:0043229;extracellular region#GO:0005576;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vacuole#GO:0005773;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 cysteine protease#PC00081;protein modifying enzyme#PC00260;protease#PC00190 HUMAN|HGNC=9847|UniProtKB=P43487 P43487 RANBP1 PTHR23138:SF182 RAN BINDING PROTEIN RAN-SPECIFIC GTPASE-ACTIVATING PROTEIN cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;nuclear export#GO:0051168;nuclear transport#GO:0051169;intracellular transport#GO:0046907;nucleocytoplasmic transport#GO:0006913;transport#GO:0006810;cellular process#GO:0009987;establishment of localization in cell#GO:0051649 nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;nucleus#GO:0005634;organelle envelope#GO:0031967;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear pore#GO:0005643;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229 scaffold/adaptor protein#PC00226 HUMAN|HGNC=7434|UniProtKB=P13995 P13995 MTHFD2 PTHR48099:SF15 C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE_CYCLOHYDROLASE, MITOCHONDRIAL catalytic activity#GO:0003824;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;oxidoreductase activity#GO:0016491;hydrolase activity#GO:0016787 biosynthetic process#GO:0009058;small molecule metabolic process#GO:0044281;folic acid-containing compound metabolic process#GO:0006760;pteridine-containing compound metabolic process#GO:0042558;cellular process#GO:0009987;modified amino acid metabolic process#GO:0006575;tetrahydrofolate metabolic process#GO:0046653;tetrahydrofolate biosynthetic process#GO:0046654;metabolic process#GO:0008152 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;cytosol#GO:0005829;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 metabolite interconversion enzyme#PC00262 Formyltetrahydrofolate biosynthesis#P02743>Methylene tetrahydrofolate dehydrogenase#P02952 HUMAN|HGNC=4167|UniProtKB=O43903 O43903 GAS2 PTHR46756:SF9 TRANSGELIN GROWTH ARREST-SPECIFIC PROTEIN 2 binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;actin filament binding#GO:0051015;protein binding#GO:0005515;protein-containing complex binding#GO:0044877 supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043 cytoskeletal protein#PC00085 HUMAN|HGNC=13567|UniProtKB=Q9NYA3 Q9NYA3 GOLGA6A PTHR10881:SF44 GOLGIN SUBFAMILY A MEMBER-RELATED GOLGIN SUBFAMILY A MEMBER 6A-RELATED endomembrane system organization#GO:0010256;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;Golgi organization#GO:0007030;cellular component organization#GO:0016043;organelle organization#GO:0006996 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;Golgi stack#GO:0005795;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;Golgi cisterna#GO:0031985;cytoplasm#GO:0005737;Golgi cis cisterna#GO:0000137;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;organelle membrane#GO:0031090;cis-Golgi network#GO:0005801;Golgi apparatus#GO:0005794 membrane traffic protein#PC00150 HUMAN|HGNC=6960|UniProtKB=Q96EZ8 Q96EZ8 MCRS1 PTHR13233:SF0 MICROSPHERULE PROTEIN 1 MICROSPHERULE PROTEIN 1 positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557 membraneless organelle#GO:0043228;intracellular protein-containing complex#GO:0140535;histone acetyltransferase complex#GO:0000123;transferase complex#GO:1990234;H4 histone acetyltransferase complex#GO:1902562;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;chromatin#GO:0000785;NSL complex#GO:0044545;intracellular anatomical structure#GO:0005622;acetyltransferase complex#GO:1902493;protein acetyltransferase complex#GO:0031248;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;chromosome#GO:0005694 HUMAN|HGNC=12367|UniProtKB=P43897 P43897 TSFM PTHR11741:SF0 ELONGATION FACTOR TS ELONGATION FACTOR TS, MITOCHONDRIAL translation factor activity#GO:0180051;translation elongation factor activity#GO:0003746 mitochondrial gene expression#GO:0140053;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;translation#GO:0006412;metabolic process#GO:0008152;translational elongation#GO:0006414;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;mitochondrial translation#GO:0032543;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739 translation elongation factor#PC00222 HUMAN|HGNC=14533|UniProtKB=P0CB47 P0CB47 UBTFL1 PTHR46318:SF1 UPSTREAM BINDING TRANSCRIPTION FACTOR UPSTREAM-BINDING FACTOR 1-LIKE PROTEIN 1-RELATED sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;core promoter sequence-specific DNA binding#GO:0001046 positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;gene expression#GO:0010467;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;regulation of biological process#GO:0050789;nucleic acid biosynthetic process#GO:0141187;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;RNA metabolic process#GO:0016070;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;transcription by RNA polymerase I#GO:0006360;positive regulation of cellular process#GO:0048522;macromolecule biosynthetic process#GO:0009059;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA biosynthetic process#GO:2001141;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;positive regulation of transcription by RNA polymerase I#GO:0045943;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;RNA biosynthetic process#GO:0032774;positive regulation of RNA metabolic process#GO:0051254;DNA-templated transcription#GO:0006351;regulation of transcription by RNA polymerase I#GO:0006356;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HUMAN|HGNC=13788|UniProtKB=Q7Z3H0 Q7Z3H0 ANKRD33 PTHR24173:SF29 ANKYRIN REPEAT CONTAINING PHOTORECEPTOR ANKYRIN REPEAT PROTEIN scaffold/adaptor protein#PC00226 HUMAN|HGNC=21998|UniProtKB=A2VEC9 A2VEC9 SSPOP PTHR11339:SF396 EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED SCO-SPONDIN extracellular matrix structural constituent#GO:0005201;structural molecule activity#GO:0005198 extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical structure#GO:0110165 extracellular matrix protein#PC00102 HUMAN|HGNC=14283|UniProtKB=Q9H5V7 Q9H5V7 IKZF5 PTHR24404:SF55 ZINC FINGER PROTEIN ZINC FINGER PROTEIN PEGASUS cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244;DNA-binding transcription factor#PC00218 HUMAN|HGNC=25632|UniProtKB=Q9BRF8 Q9BRF8 CPPED1 PTHR43143:SF1 METALLOPHOSPHOESTERASE, CALCINEURIN SUPERFAMILY SERINE_THREONINE-PROTEIN PHOSPHATASE CPPED1 protein modifying enzyme#PC00260;protein phosphatase#PC00195 HUMAN|HGNC=29960|UniProtKB=Q8IYS5 Q8IYS5 OSCAR PTHR11738:SF198 MHC CLASS I NK CELL RECEPTOR OSTEOCLAST-ASSOCIATED IMMUNOGLOBULIN-LIKE RECEPTOR molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 cellular developmental process#GO:0048869;developmental process#GO:0032502;biological regulation#GO:0065007;hemopoiesis#GO:0030097;cellular process#GO:0009987;signal transduction#GO:0007165;osteoclast differentiation#GO:0030316;anatomical structure development#GO:0048856;cell communication#GO:0007154;cell development#GO:0048468;signaling#GO:0023052;regulation of cellular process#GO:0050794;myeloid cell differentiation#GO:0030099;cell differentiation#GO:0030154;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;leukocyte differentiation#GO:0002521 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=21025|UniProtKB=Q9NPB0 Q9NPB0 SAYSD1 PTHR13527:SF0 SAYSVFN DOMAIN-CONTAINING PROTEIN 1 SAYSVFN DOMAIN-CONTAINING PROTEIN 1 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 protein quality control for misfolded or incompletely synthesized proteins#GO:0006515;catabolic process#GO:0009056;cytoplasmic translation#GO:0002181;protein biosynthetic process#GO:0160307;rescue of stalled cytosolic ribosome#GO:0072344;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;organelle disassembly#GO:1903008;protein metabolic process#GO:0019538;cellular component disassembly#GO:0022411;protein catabolic process#GO:0030163;translation#GO:0006412;biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;organelle organization#GO:0006996;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;translational elongation#GO:0006414;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 HUMAN|HGNC=26773|UniProtKB=Q52LJ0 Q52LJ0 FAM98B PTHR31353:SF11 FAM98 TRNA-SPLICING LIGASE COMPLEX SUBUNIT FAM98B catalytic complex#GO:1902494;intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991 RNA splicing factor#PC00148;RNA processing factor#PC00147 HUMAN|HGNC=6118|UniProtKB=Q14653 Q14653 IRF3 PTHR11949:SF1 INTERFERON REGULATORY FACTOR INTERFERON REGULATORY FACTOR 3 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;winged helix/forkhead transcription factor#PC00246 Toll receptor signaling pathway#P00054>IRF3#P01374 HUMAN|HGNC=18866|UniProtKB=Q6UVM3 Q6UVM3 KCNT2 PTHR10027:SF9 CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN POTASSIUM CHANNEL SUBFAMILY T MEMBER 2 monoatomic ion-gated channel activity#GO:0022839;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261;ligand-gated monoatomic ion channel activity#GO:0015276;outward rectifier potassium channel activity#GO:0015271;potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;transporter activity#GO:0005215;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324 monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;transport#GO:0006810;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;metal ion transport#GO:0030001;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 ion channel#PC00133;transporter#PC00227 HUMAN|HGNC=14845|UniProtKB=Q8NGN5 Q8NGN5 OR10G8 PTHR26453:SF682 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 10G8 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 sensory perception#GO:0007600;nervous system process#GO:0050877;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;detection of chemical stimulus#GO:0009593;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;response to chemical#GO:0042221;response to stimulus#GO:0050896;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=11368|UniProtKB=P42226 P42226 STAT6 PTHR11801:SF48 SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 cell surface receptor signaling pathway via STAT#GO:0097696;response to chemical#GO:0042221;response to cytokine#GO:0034097;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;cellular process#GO:0009987;response to stress#GO:0006950;response to hormone#GO:0009725;cell surface receptor signaling pathway#GO:0007166;signaling#GO:0023052;cellular response to endogenous stimulus#GO:0071495;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;cellular response to hormone stimulus#GO:0032870;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;response to peptide#GO:1901652;response to oxygen-containing compound#GO:1901700;cellular response to chemical stimulus#GO:0070887;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;response to peptide hormone#GO:0043434;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular response to nitrogen compound#GO:1901699;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;defense response#GO:0006952;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cell surface receptor signaling pathway via JAK-STAT#GO:0007259;cellular response to peptide hormone stimulus#GO:0071375;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;response to nitrogen compound#GO:1901698;regulation of RNA metabolic process#GO:0051252;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of DNA-templated transcription#GO:0006355;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cytokine-mediated signaling pathway#GO:0019221 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular organelle#GO:0043229 immunoglobulin fold transcription factor#PC00251;Rel homology transcription factor#PC00252 Interleukin signaling pathway#P00036>STAT#P00996;EGF receptor signaling pathway#P00018>STAT#P00561;PDGF signaling pathway#P00047>STAT#P01173;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>STAT#P00832;JAK/STAT signaling pathway#P00038>STAT#P01027 HUMAN|HGNC=18562|UniProtKB=Q99581 Q99581 FEV PTHR11849:SF203 ETS PROTEIN FEV DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110 regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;developmental process#GO:0032502;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 winged helix/forkhead transcription factor#PC00246;DNA-binding transcription factor#PC00218 PDGF signaling pathway#P00047>Ets#P01167 HUMAN|HGNC=15009|UniProtKB=Q8NG85 Q8NG85 OR2L3 PTHR26453:SF680 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2L3 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 detection of chemical stimulus#GO:0009593;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;response to chemical#GO:0042221;response to stimulus#GO:0050896;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;sensory perception#GO:0007600;nervous system process#GO:0050877;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;system process#GO:0003008 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=33825|UniProtKB=Q6IE38 Q6IE38 SPINK14 PTHR47499:SF3 SERINE PROTEASE INHIBITOR KAZAL-TYPE 7 SPINK7 SERINE PROTEASE INHIBITOR KAZAL-TYPE 14 enzyme inhibitor activity#GO:0004857;molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866;peptidase regulator activity#GO:0061134;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414;serine-type endopeptidase inhibitor activity#GO:0004867;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234 negative regulation of cellular process#GO:0048523;regulation of proteolysis#GO:0030162;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of protein metabolic process#GO:0051248;negative regulation of metabolic process#GO:0009892;biological regulation#GO:0065007;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;negative regulation of biological process#GO:0048519;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;negative regulation of macromolecule metabolic process#GO:0010605 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protein-binding activity modulator#PC00095;protease inhibitor#PC00191 HUMAN|HGNC=23167|UniProtKB=Q86U02 Q86U02 LINC00596 PTHR46254:SF6 PROTEIN GVQW1-RELATED HIGH MOBILITY GROUP AT-HOOK 2 HUMAN|HGNC=11905|UniProtKB=O14763 O14763 TNFRSF10B PTHR46330:SF18 TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10B TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10B molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;death receptor activity#GO:0005035;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell death#GO:0008219;apoptotic process#GO:0006915;regulation of programmed cell death#GO:0043067;programmed cell death#GO:0012501;signaling#GO:0023052;response to stimulus#GO:0050896;extrinsic apoptotic signaling pathway#GO:0097191;regulation of cellular process#GO:0050794;positive regulation of programmed cell death#GO:0043068;cell communication#GO:0007154;signal transduction#GO:0007165;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;biological regulation#GO:0065007;cell surface receptor signaling pathway#GO:0007166;regulation of apoptotic process#GO:0042981;positive regulation of apoptotic process#GO:0043065;extrinsic apoptotic signaling pathway via death domain receptors#GO:0008625;apoptotic signaling pathway#GO:0097190 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cell surface#GO:0009986;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 p53 pathway#P00059>KILLER/DR5#G01568;Apoptosis signaling pathway#P00006>TRAIL-R#P00276 HUMAN|HGNC=32220|UniProtKB=Q6IPT4 Q6IPT4 CYB5RL PTHR19370:SF184 NADH-CYTOCHROME B5 REDUCTASE NADH-CYTOCHROME B5 REDUCTASE-LIKE catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 reductase#PC00198;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=28727|UniProtKB=Q9BUR5 Q9BUR5 APOO PTHR14564:SF2 MICOS COMPLEX SUBUNIT MIC26 / MIC27 FAMILY MEMBER MICOS COMPLEX SUBUNIT MIC26 inner mitochondrial membrane organization#GO:0007007;cellular process#GO:0009987;mitochondrial membrane organization#GO:0007006;cellular component organization#GO:0016043;organelle organization#GO:0006996;membrane organization#GO:0061024;mitochondrion organization#GO:0007005;cellular component organization or biogenesis#GO:0071840 membrane protein complex#GO:0098796;organelle envelope#GO:0031967;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;mitochondrial membrane#GO:0031966;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;inner mitochondrial membrane protein complex#GO:0098800;organelle membrane#GO:0031090 HUMAN|HGNC=24008|UniProtKB=Q5JRA6 Q5JRA6 MIA3 PTHR23158:SF54 MELANOMA INHIBITORY ACTIVITY-RELATED TRANSPORT AND GOLGI ORGANIZATION PROTEIN 1 HOMOLOG establishment of protein localization to extracellular region#GO:0035592;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;Golgi vesicle transport#GO:0048193;transport#GO:0006810;intracellular transport#GO:0046907;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;macromolecule localization#GO:0033036;protein transport#GO:0015031;secretion by cell#GO:0032940;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;secretion#GO:0046903;protein secretion#GO:0009306;localization#GO:0051179;export from cell#GO:0140352;protein localization to extracellular region#GO:0071692 organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endoplasmic reticulum exit site#GO:0070971;endomembrane system#GO:0012505;cytoplasm#GO:0005737;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;intracellular membrane-bounded organelle#GO:0043231 membrane traffic protein#PC00150 HUMAN|Ensembl=ENSG00000293689.1|UniProtKB=A0ABB0MVE3 A0ABB0MVE3 PTHR15566:SF4 POM121-LIKE POM121-LIKE PROTEIN 1-RELATED HUMAN|HGNC=10012|UniProtKB=P08100 P08100 RHO PTHR24240:SF15 OPSIN RHODOPSIN transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089 regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to abiotic stimulus#GO:0009628;signaling#GO:0023052;cellular response to radiation#GO:0071478;response to stimulus#GO:0050896;response to light stimulus#GO:0009416;cellular response to environmental stimulus#GO:0104004;regulation of cellular process#GO:0050794;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;signal transduction#GO:0007165;response to radiation#GO:0009314;cellular process#GO:0009987;cellular response to light stimulus#GO:0071482;detection of stimulus#GO:0051606;biological regulation#GO:0065007;response to external stimulus#GO:0009605;cellular response to abiotic stimulus#GO:0071214 non-motile cilium#GO:0097730;membrane-bounded organelle#GO:0043227;cilium#GO:0005929;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;photoreceptor outer segment#GO:0001750;photoreceptor cell cilium#GO:0097733;cell periphery#GO:0071944;neuron projection#GO:0043005;membrane#GO:0016020;9+0 non-motile cilium#GO:0097731 G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Rhodopsin#P00747 HUMAN|HGNC=1232|UniProtKB=Q9GZT9 Q9GZT9 EGLN1 PTHR12907:SF4 EGL NINE HOMOLOG-RELATED EGL NINE HOMOLOG 1 2-oxoglutarate-dependent dioxygenase activity#GO:0016706;oxidoreductase activity#GO:0016491;catalytic activity, acting on a protein#GO:0140096;iron ion binding#GO:0005506;catalytic activity#GO:0003824;ferrous iron binding#GO:0008198;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;metal ion binding#GO:0046872;dioxygenase activity#GO:0051213;cation binding#GO:0043169;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;transition metal ion binding#GO:0046914 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to hypoxia#GO:0071456;response to abiotic stimulus#GO:0009628;response to oxygen levels#GO:0070482;response to decreased oxygen levels#GO:0036293;regulation of programmed cell death#GO:0043067;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cellular response to chemical stimulus#GO:0070887;cellular response to stress#GO:0033554;response to chemical#GO:0042221;biological regulation#GO:0065007;response to stress#GO:0006950;regulation of neuron apoptotic process#GO:0043523;cellular process#GO:0009987;response to hypoxia#GO:0001666;regulation of apoptotic process#GO:0042981 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 Hypoxia response via HIF activation#P00030>Prolyl Hydroxylase#P00821 HUMAN|HGNC=10383|UniProtKB=P46783 P46783 RPS10 PTHR12146:SF10 40S RIBOSOMAL PROTEIN S10 SMALL RIBOSOMAL SUBUNIT PROTEIN ES10 binding#GO:0005488;structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;structural molecule activity#GO:0005198 ribosome#GO:0005840;cytosolic ribosome#GO:0022626;cytosol#GO:0005829;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;small ribosomal subunit#GO:0015935;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;cytosolic small ribosomal subunit#GO:0022627;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 ribosomal protein#PC00202 HUMAN|HGNC=28738|UniProtKB=Q5THK1 Q5THK1 PRR14L PTHR14522:SF0 EMO2-RELATED PROTEIN PRR14L HUMAN|HGNC=11860|UniProtKB=Q9BZW5 Q9BZW5 TM6SF1 PTHR14568:SF10 TRANSMEMBRANE SUPERFAMILY 6 MEMBER 1/2 TRANSMEMBRANE 6 SUPERFAMILY MEMBER 1 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;lysosome#GO:0005764;lytic vacuole membrane#GO:0098852;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;vacuolar membrane#GO:0005774;lytic vacuole#GO:0000323;cytoplasm#GO:0005737;vacuole#GO:0005773;lysosomal membrane#GO:0005765;membrane#GO:0016020 HUMAN|HGNC=9219|UniProtKB=Q12837 Q12837 POU4F2 PTHR11636:SF41 POU DOMAIN POU DOMAIN, CLASS 4, TRANSCRIPTION FACTOR 2 cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=20187|UniProtKB=Q96BY7 Q96BY7 ATG2B PTHR13190:SF20 AUTOPHAGY-RELATED 2, ISOFORM A AUTOPHAGY-RELATED PROTEIN 2 HOMOLOG B phosphatidylinositol-3-phosphate binding#GO:0032266;phosphatidylinositol phosphate binding#GO:1901981;phospholipid binding#GO:0005543;molecular adaptor activity#GO:0060090;lipid binding#GO:0008289;protein-membrane adaptor activity#GO:0043495;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674 glucan catabolic process#GO:0009251;polysaccharide metabolic process#GO:0005976;polysaccharide catabolic process#GO:0000272;cellular component organization#GO:0016043;glucan metabolic process#GO:0044042;process utilizing autophagic mechanism#GO:0061919;carbohydrate catabolic process#GO:0016052;cellular component assembly#GO:0022607;cellular process#GO:0009987;autophagosome organization#GO:1905037;autophagy#GO:0006914;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;autophagosome assembly#GO:0000045;cellular component organization or biogenesis#GO:0071840;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;piecemeal microautophagy of the nucleus#GO:0034727;carbohydrate metabolic process#GO:0005975;catabolic process#GO:0009056;primary metabolic process#GO:0044238;glycogen metabolic process#GO:0005977;vacuole organization#GO:0007033;energy reserve metabolic process#GO:0006112;organelle assembly#GO:0070925;macroautophagy#GO:0016236;reticulophagy#GO:0061709;glycogen catabolic process#GO:0005980;energy derivation by oxidation of organic compounds#GO:0015980;macromolecule metabolic process#GO:0043170;pexophagy#GO:0000425;generation of precursor metabolites and energy#GO:0006091;autophagy of mitochondrion#GO:0000422 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;phagophore assembly site#GO:0000407 HUMAN|HGNC=7574|UniProtKB=Q9Y623 Q9Y623 MYH4 PTHR45615:SF79 MYOSIN HEAVY CHAIN, NON-MUSCLE MYOSIN-4 protein-containing complex binding#GO:0044877;protein binding#GO:0005515;actin binding#GO:0003779;actin filament binding#GO:0051015;ATP-dependent activity#GO:0140657;binding#GO:0005488;polypeptide conformation or assembly isomerase activity#GO:0120544;isomerase activity#GO:0016853;cytoskeletal motor activity#GO:0003774;macromolecular conformation isomerase activity#GO:0120543;cytoskeletal protein binding#GO:0008092;catalytic activity#GO:0003824;microfilament motor activity#GO:0000146 system process#GO:0003008;multicellular organismal process#GO:0032501;muscle system process#GO:0003012;muscle contraction#GO:0006936 myosin complex#GO:0016459;actin cytoskeleton#GO:0015629;supramolecular complex#GO:0099080;organelle#GO:0043226;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622 actin or actin-binding cytoskeletal protein#PC00041 Cytoskeletal regulation by Rho GTPase#P00016>Myosin#P00522;Wnt signaling pathway#P00057>NFAT Target Genes#G01559;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Myosin#P00867;Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HUMAN|HGNC=9413|UniProtKB=P78527 P78527 PRKDC PTHR11139:SF68 ATAXIA TELANGIECTASIA MUTATED ATM -RELATED DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 cellular response to stress#GO:0033554;somatic diversification of immune receptors via germline recombination within a single locus#GO:0002562;immune system process#GO:0002376;animal gross anatomical part developmental process#GO:0160108;immune system development#GO:0002520;intrinsic apoptotic signaling pathway#GO:0097193;regulation of biological process#GO:0050789;apoptotic process#GO:0006915;V(D)J recombination#GO:0033151;cellular component organization#GO:0016043;signaling#GO:0023052;response to stimulus#GO:0050896;production of molecular mediator of immune response#GO:0002440;DNA recombination#GO:0006310;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;double-strand break repair#GO:0006302;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;signal transduction#GO:0007165;somatic recombination of immunoglobulin gene segments#GO:0016447;cellular process#GO:0009987;intrinsic apoptotic signaling pathway in response to DNA damage#GO:0008630;organelle organization#GO:0006996;response to stress#GO:0006950;gene expression#GO:0010467;telomere organization#GO:0032200;system development#GO:0048731;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;anatomical structure development#GO:0048856;cell death#GO:0008219;cellular response to stimulus#GO:0051716;somatic diversification of immune receptors#GO:0002200;primary metabolic process#GO:0044238;programmed cell death#GO:0012501;nucleic acid metabolic process#GO:0090304;regulation of cellular process#GO:0050794;developmental process#GO:0032502;DNA damage response#GO:0006974;DNA repair#GO:0006281;chromosome organization#GO:0051276;telomere maintenance#GO:0000723;macromolecule metabolic process#GO:0043170;apoptotic signaling pathway#GO:0097190;macromolecule biosynthetic process#GO:0009059;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;biological regulation#GO:0065007;somatic cell DNA recombination#GO:0016444;multicellular organismal process#GO:0032501 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=8264|UniProtKB=Q8NGT1 Q8NGT1 OR2K2 PTHR26453:SF198 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2K2 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;nervous system process#GO:0050877;sensory perception#GO:0007600;system process#GO:0003008;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;detection of chemical stimulus#GO:0009593;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;response to stimulus#GO:0050896;response to chemical#GO:0042221 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=1166|UniProtKB=Q02833 Q02833 RASSF7 PTHR15286:SF11 RAS-ASSOCIATING DOMAIN CONTAINING PROTEIN RAS ASSOCIATION DOMAIN-CONTAINING PROTEIN 7 scaffold/adaptor protein#PC00226 HUMAN|HGNC=4236|UniProtKB=P55789 P55789 GFER PTHR12645:SF3 ALR/ERV FAD-LINKED SULFHYDRYL OXIDASE ALR ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265;flavin adenine dinucleotide binding#GO:0050660;anion binding#GO:0043168;binding#GO:0005488;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;small molecule binding#GO:0036094;protein-disulfide reductase activity#GO:0015035;catalytic activity#GO:0003824;nucleotide binding#GO:0000166;disulfide oxidoreductase activity#GO:0015036;heterocyclic compound binding#GO:1901363;oxidoreductase activity#GO:0016491;catalytic activity, acting on a protein#GO:0140096 multicellular organismal process#GO:0032501;liver development#GO:0001889;animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502;animal organ development#GO:0048513;anatomical structure development#GO:0048856;multicellular organism development#GO:0007275;system development#GO:0048731 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 oxidoreductase#PC00176;oxidase#PC00175 HUMAN|HGNC=20766|UniProtKB=Q71U36 Q71U36 TUBA1A PTHR11588:SF133 TUBULIN TUBULIN ALPHA-1A CHAIN purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;binding#GO:0005488;structural constituent of cytoskeleton#GO:0005200;nucleoside phosphate binding#GO:1901265;guanyl nucleotide binding#GO:0019001;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;nucleotide binding#GO:0000166;structural molecule activity#GO:0005198;small molecule binding#GO:0036094;anion binding#GO:0043168;ion binding#GO:0043167 cell differentiation#GO:0030154;mitotic cell cycle#GO:0000278;cell cycle#GO:0007049;cellular component organization#GO:0016043;system development#GO:0048731;microtubule cytoskeleton organization#GO:0000226;anatomical structure development#GO:0048856;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cytoskeleton organization#GO:0007010;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;cellular process#GO:0009987;organelle organization#GO:0006996;microtubule-based process#GO:0007017;neurogenesis#GO:0022008;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;developmental process#GO:0032502;neuron differentiation#GO:0030182 supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;supramolecular complex#GO:0099080;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;microtubule cytoskeleton#GO:0015630 cytoskeletal protein#PC00085;tubulin#PC00228 Gonadotropin-releasing hormone receptor pathway#P06664>Tubulin#P06772 HUMAN|HGNC=16891|UniProtKB=Q96RU8 Q96RU8 TRIB1 PTHR22961:SF17 SER/THR PROTEIN KINASE-TRB TRIBBLES HOMOLOG 1 protein binding#GO:0005515;kinase binding#GO:0019900;binding#GO:0005488;protein kinase binding#GO:0019901;enzyme binding#GO:0019899 regulation of ubiquitin-dependent protein catabolic process#GO:2000058;regulation of catabolic process#GO:0009894;positive regulation of catabolic process#GO:0009896;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;positive regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032436;regulation of proteasomal protein catabolic process#GO:0061136;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of protein metabolic process#GO:0051247;regulation of protein catabolic process#GO:0042176;positive regulation of protein catabolic process#GO:0045732;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434;positive regulation of metabolic process#GO:0009893;positive regulation of ubiquitin-dependent protein catabolic process#GO:2000060;regulation of biological process#GO:0050789;positive regulation of proteasomal protein catabolic process#GO:1901800;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=27880|UniProtKB=Q6ZTN6 Q6ZTN6 ANKRD13D PTHR12447:SF2 ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13 ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13D molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 regulation of localization#GO:0032879;regulation of transport#GO:0051049;regulation of endocytosis#GO:0030100;biological regulation#GO:0065007;regulation of cellular component organization#GO:0051128;regulation of receptor-mediated endocytosis#GO:0048259;regulation of cellular process#GO:0050794;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular vesicle#GO:0097708;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;plasma membrane#GO:0005886;endomembrane system#GO:0012505;late endosome#GO:0005770;cell periphery#GO:0071944;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HUMAN|HGNC=13312|UniProtKB=P78417 P78417 GSTO1 PTHR43968:SF5 FAMILY NOT NAMED GLUTATHIONE S-TRANSFERASE OMEGA-1 glutathione transferase activity#GO:0004364;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;disulfide oxidoreductase activity#GO:0015036;oxidoreductase activity#GO:0016491;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;catalytic activity#GO:0003824;transferase activity#GO:0016740;antioxidant activity#GO:0016209 L-ascorbic acid metabolic process#GO:0019852;cellular process#GO:0009987;carboxylic acid metabolic process#GO:0019752;modified amino acid metabolic process#GO:0006575;sulfur compound metabolic process#GO:0006790;primary metabolic process#GO:0044238;carbohydrate metabolic process#GO:0005975;small molecule metabolic process#GO:0044281;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;monosaccharide metabolic process#GO:0005996;glutathione metabolic process#GO:0006749 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=3290|UniProtKB=O60516 O60516 EIF4EBP3 PTHR12669:SF5 EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 3 binding#GO:0005488;protein binding#GO:0005515;translation initiation factor binding#GO:0031369;translation regulator activity#GO:0045182 negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of protein metabolic process#GO:0051248;negative regulation of metabolic process#GO:0009892;negative regulation of translation#GO:0017148;regulation of translational initiation#GO:0006446;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 translation factor#PC00223;translation initiation factor#PC00224 HUMAN|HGNC=26411|UniProtKB=Q7Z353 Q7Z353 HDX PTHR11636:SF80 POU DOMAIN HIGHLY DIVERGENT HOMEOBOX transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255 RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=28781|UniProtKB=Q86V88 Q86V88 MDP1 PTHR17901:SF14 MAGNESIUM-DEPENDENT PHOSPHATASE 1 MDP1 MAGNESIUM-DEPENDENT PHOSPHATASE 1 phosphatase#PC00181;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=11503|UniProtKB=O43426 O43426 SYNJ1 PTHR11200:SF158 INOSITOL 5-PHOSPHATASE POLYPHOSPHATIDYLINOSITOL PHOSPHATASE SYNJ1 catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578 synaptic vesicle recycling#GO:0036465;vesicle-mediated transport#GO:0016192;endocytosis#GO:0006897;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;synaptic vesicle endocytosis#GO:0048488;localization#GO:0051179;cellular localization#GO:0051641;vesicle-mediated transport in synapse#GO:0099003;establishment of localization#GO:0051234;import into cell#GO:0098657;synaptic vesicle cycle#GO:0099504;transport#GO:0006810 intracellular anatomical structure#GO:0005622;cell junction#GO:0030054;perinuclear region of cytoplasm#GO:0048471;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;synapse#GO:0045202;presynapse#GO:0098793;membrane#GO:0016020 phosphatase#PC00181;hydrolase#PC00121 Huntington disease#P00029>Synaptojanin#P00804 HUMAN|HGNC=12362|UniProtKB=Q92574 Q92574 TSC1 PTHR15154:SF2 HAMARTIN HAMARTIN negative regulation of cell population proliferation#GO:0008285;regulation of TOR signaling#GO:0032006;negative regulation of response to stimulus#GO:0048585;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of signal transduction#GO:0009968;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of TOR signaling#GO:0032007;regulation of cellular process#GO:0050794;regulation of cell cycle#GO:0051726;regulation of cell communication#GO:0010646;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;regulation of cell population proliferation#GO:0042127;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 Insulin/IGF pathway-protein kinase B signaling cascade#P00033>TSC1#P04495;p53 pathway by glucose deprivation#P04397>TSC1#P04645 HUMAN|HGNC=37701|UniProtKB=P0CG01 P0CG01 GKN3P PTHR16483:SF2 GASTROKINE 1 GASTROKINE-3 biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of cell population proliferation#GO:0042127;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=1063|UniProtKB=P30043 P30043 BLVRB PTHR43355:SF2 FLAVIN REDUCTASE (NADPH) FLAVIN REDUCTASE (NADPH) oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 reductase#PC00198 HUMAN|HGNC=20967|UniProtKB=Q96RE7 Q96RE7 NACC1 PTHR46105:SF3 AGAP004733-PA NUCLEUS ACCUMBENS-ASSOCIATED PROTEIN 1 nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=7659|UniProtKB=P52298 P52298 NCBP2 PTHR18847:SF6 20 KD NUCLEAR CAP BINDING PROTEIN NUCLEAR CAP-BINDING PROTEIN SUBUNIT 2 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;mRNA processing#GO:0006397;RNA processing#GO:0006396;gene expression#GO:0010467;RNA catabolic process#GO:0006401;nucleic acid biosynthetic process#GO:0141187;cellular localization#GO:0051641;RNA metabolic process#GO:0016070;mRNA export from nucleus#GO:0006406;mRNA splicing, via spliceosome#GO:0000398;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;transport#GO:0006810;intracellular transport#GO:0046907;negative regulation of cellular process#GO:0048523;RNA export from nucleus#GO:0006405;regulation of gene expression#GO:0010468;nuclear-transcribed mRNA catabolic process#GO:0000956;establishment of localization#GO:0051234;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;nucleic acid catabolic process#GO:0141188;macromolecule biosynthetic process#GO:0009059;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;nitrogen compound transport#GO:0071705;regulation of macromolecule biosynthetic process#GO:0010556;macromolecule localization#GO:0033036;nucleobase-containing compound catabolic process#GO:0034655;biosynthetic process#GO:0009058;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;nucleocytoplasmic transport#GO:0006913;RNA splicing, via transesterification reactions#GO:0000375;nuclear export#GO:0051168;nuclear transport#GO:0051169;nucleic acid transport#GO:0050657;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;localization#GO:0051179;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;establishment of RNA localization#GO:0051236;RNA biosynthetic process#GO:0032774;mRNA transport#GO:0051028;regulation of cellular process#GO:0050794;RNA transport#GO:0050658;RNA localization#GO:0006403;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;nucleobase-containing compound transport#GO:0015931 intracellular organelle#GO:0043229;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 RNA metabolism protein#PC00031 HUMAN|HGNC=19856|UniProtKB=Q52LA3 Q52LA3 LIN52 PTHR31489:SF2 LIN52 FAMILY MEMBER PROTEIN LIN-52 HOMOLOG HUMAN|HGNC=3468|UniProtKB=Q92731 Q92731 ESR2 PTHR48092:SF12 KNIRPS-RELATED PROTEIN-RELATED ESTROGEN RECEPTOR BETA sequence-specific double-stranded DNA binding#GO:1990837;molecular transducer activity#GO:0060089;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;nuclear receptor activity#GO:0004879;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulator activity#GO:0140110 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of nucleobase-containing compound metabolic process#GO:0019219;nuclear receptor-mediated signaling pathway#GO:0141193;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;nuclear receptor-mediated steroid hormone signaling pathway#GO:0030518;regulation of DNA-templated transcription#GO:0006355;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of RNA metabolic process#GO:0051252;response to steroid hormone#GO:0048545;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;intracellular receptor signaling pathway#GO:0030522;cellular response to stimulus#GO:0051716;steroid hormone receptor signaling pathway#GO:0043401;cellular response to steroid hormone stimulus#GO:0071383;response to lipid#GO:0033993;cellular response to lipid#GO:0071396;response to chemical#GO:0042221;response to hormone#GO:0009725;cellular process#GO:0009987;signal transduction#GO:0007165;hormone-mediated signaling pathway#GO:0009755;cellular response to chemical stimulus#GO:0070887;cellular response to hormone stimulus#GO:0032870;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;signaling#GO:0023052;estrogen receptor signaling pathway#GO:0030520;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694;nucleus#GO:0005634;chromatin#GO:0000785 C4 zinc finger nuclear receptor#PC00169;zinc finger transcription factor#PC00244 HUMAN|HGNC=27283|UniProtKB=Q8NHP8 Q8NHP8 PLBD2 PTHR12370:SF3 N-TERMINAL NUCLEOPHILE (NTN) HYDROLASE AMINOPEPTIDASE PLBD2-RELATED extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 phospholipase#PC00186 HUMAN|HGNC=22228|UniProtKB=A5PL33 A5PL33 KRABD3 PTHR22740:SF3 PROTEIN KRBA1 KRAB DOMAIN-CONTAINING PROTEIN 3 HUMAN|HGNC=7824|UniProtKB=Q92982 Q92982 NINJ1 PTHR12316:SF19 NINJURIN-RELATED NINJURIN-1 protein binding#GO:0005515;cell-cell adhesion mediator activity#GO:0098632;binding#GO:0005488;cell adhesion molecule binding#GO:0050839;cell adhesion mediator activity#GO:0098631 defense response#GO:0006952;inflammatory response#GO:0006954;cell adhesion#GO:0007155;response to stimulus#GO:0050896;cell death#GO:0008219;cellular process#GO:0009987;programmed cell death#GO:0012501;response to stress#GO:0006950 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 cell adhesion molecule#PC00069 HUMAN|HGNC=19154|UniProtKB=Q9UKL4 Q9UKL4 GJD2 PTHR11984:SF32 CONNEXIN GAP JUNCTION DELTA-2 PROTEIN wide pore channel activity#GO:0022829;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 cell communication#GO:0007154;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;signaling#GO:0023052;cellular process#GO:0009987;regulation of biological process#GO:0050789 anchoring junction#GO:0070161;cell junction#GO:0030054;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;cell-cell junction#GO:0005911;membrane#GO:0016020;membrane protein complex#GO:0098796 cell junction protein#PC00070;gap junction#PC00105 HUMAN|HGNC=1874|UniProtKB=P23528 P23528 CFL1 PTHR11913:SF17 COFILIN-RELATED COFILIN-1 actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;actin filament binding#GO:0051015;binding#GO:0005488;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 cell division#GO:0051301;cell cycle process#GO:0022402;cellular component organization#GO:0016043;cell cycle#GO:0007049;protein-containing complex disassembly#GO:0032984;mitotic cytokinesis#GO:0000281;actin cytoskeleton organization#GO:0030036;mitotic cell cycle#GO:0000278;actin filament-based process#GO:0030029;cytokinesis#GO:0000910;supramolecular fiber organization#GO:0097435;cellular component disassembly#GO:0022411;cytoskeleton-dependent cytokinesis#GO:0061640;actin polymerization or depolymerization#GO:0008154;cellular process#GO:0009987;actin filament depolymerization#GO:0030042;organelle organization#GO:0006996;protein depolymerization#GO:0051261;cytoskeleton organization#GO:0007010;protein-containing complex organization#GO:0043933;mitotic cell cycle process#GO:1903047;actin filament organization#GO:0007015;cellular component organization or biogenesis#GO:0071840 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;lamellipodium#GO:0030027;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell leading edge#GO:0031252;actin cytoskeleton#GO:0015629 non-motor actin binding protein#PC00165 Cytoskeletal regulation by Rho GTPase#P00016>Cofilin#P00508 HUMAN|HGNC=30720|UniProtKB=Q8NA61 Q8NA61 CBY2 PTHR21533:SF13 LEUCINE-RICH PROTEIN PROTEIN CHIBBY HOMOLOG 2 HUMAN|HGNC=16283|UniProtKB=Q14142 Q14142 TRIM14 PTHR24103:SF595 E3 UBIQUITIN-PROTEIN LIGASE TRIM TRIPARTITE MOTIF-CONTAINING PROTEIN 14 aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746 response to stimulus#GO:0050896;defense response to other organism#GO:0098542;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to other organism#GO:0051707;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;immune response#GO:0006955;defense response to symbiont#GO:0140546;innate immune response#GO:0045087;response to external stimulus#GO:0009605;defense response#GO:0006952;immune system process#GO:0002376 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=33274|UniProtKB=A6NDB9 A6NDB9 PALM3 PTHR47528:SF1 PARALEMMIN-3 PARALEMMIN-3 cell communication#GO:0007154;response to bacterium#GO:0009617;negative regulation of response to cytokine stimulus#GO:0060761;response to external biotic stimulus#GO:0043207;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;response to external stimulus#GO:0009605;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;response to other organism#GO:0051707;negative regulation of response to stimulus#GO:0048585;negative regulation of cell communication#GO:0010648;response to oxygen-containing compound#GO:1901700;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;response to molecule of bacterial origin#GO:0002237;negative regulation of biological process#GO:0048519;regulation of cytokine-mediated signaling pathway#GO:0001959;response to lipopolysaccharide#GO:0032496;negative regulation of cytokine-mediated signaling pathway#GO:0001960;cell surface receptor signaling pathway#GO:0007166;negative regulation of signal transduction#GO:0009968;response to chemical#GO:0042221;response to lipid#GO:0033993;signal transduction#GO:0007165;cellular process#GO:0009987;response to biotic stimulus#GO:0009607;regulation of response to cytokine stimulus#GO:0060759 HUMAN|HGNC=4122|UniProtKB=P34059 P34059 GALNS PTHR42693:SF47 ARYLSULFATASE FAMILY MEMBER N-ACETYLGALACTOSAMINE-6-SULFATASE hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788 hydrolase#PC00121 HUMAN|HGNC=22042|UniProtKB=Q8N8L6 Q8N8L6 ARL10 PTHR47575:SF1 ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 10 ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 10 HUMAN|HGNC=9320|UniProtKB=Q8TF05 Q8TF05 PPP4R1 PTHR10648:SF8 SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 1 protein complex scaffold activity#GO:0140378;structural molecule activity#GO:0005198 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 phosphatase modulator#PC00184 FGF signaling pathway#P00021>PP2A#P00629 HUMAN|HGNC=1713|UniProtKB=Q8IWY9 Q8IWY9 CDAN1 PTHR28678:SF1 CODANIN-1 CODANIN-1 cellular process#GO:0009987;cellular component organization#GO:0016043;chromatin organization#GO:0006325;cellular component organization or biogenesis#GO:0071840 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=24727|UniProtKB=A0AVK6 A0AVK6 E2F8 PTHR12081:SF40 TRANSCRIPTION FACTOR E2F TRANSCRIPTION FACTOR E2F8 DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=7939|UniProtKB=P01160 P01160 NPPA PTHR14066:SF2 ATRIAL NATRIURETIC FACTOR PRECURSOR NATRIURETIC PEPTIDES A binding#GO:0005488;hormone receptor binding#GO:0051427;signaling receptor binding#GO:0005102;molecular function activator activity#GO:0140677;hormone activity#GO:0005179;protein binding#GO:0005515;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772 phosphorus metabolic process#GO:0006793;purine nucleotide metabolic process#GO:0006163;regulation of biological process#GO:0050789;purine-containing compound metabolic process#GO:0072521;response to stimulus#GO:0050896;small molecule metabolic process#GO:0044281;signaling#GO:0023052;purine-containing compound biosynthetic process#GO:0072522;G protein-coupled receptor signaling pathway#GO:0007186;purine nucleotide biosynthetic process#GO:0006164;ribonucleotide metabolic process#GO:0009259;cyclic nucleotide biosynthetic process#GO:0009190;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide biosynthetic process#GO:0009165;regulation of biological quality#GO:0065008;regulation of systemic arterial blood pressure#GO:0003073;ribose phosphate biosynthetic process#GO:0046390;receptor guanylyl cyclase signaling pathway#GO:0007168;signal transduction#GO:0007165;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing compound biosynthetic process#GO:0034654;cyclic purine nucleotide metabolic process#GO:0052652;cell surface receptor signaling pathway#GO:0007166;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;primary metabolic process#GO:0044238;neuropeptide signaling pathway#GO:0007218;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;nucleoside phosphate metabolic process#GO:0006753;circulatory system process#GO:0003013;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;cGMP biosynthetic process#GO:0006182;organophosphate biosynthetic process#GO:0090407;regulation of blood pressure#GO:0008217;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;carbohydrate derivative metabolic process#GO:1901135;cGMP metabolic process#GO:0046068;blood circulation#GO:0008015;multicellular organismal process#GO:0032501;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;biosynthetic process#GO:0009058;cyclic nucleotide metabolic process#GO:0009187;nucleoside phosphate biosynthetic process#GO:1901293;system process#GO:0003008 extracellular region#GO:0005576;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=10434|UniProtKB=O75582 O75582 RPS6KA5 PTHR24351:SF115 RIBOSOMAL PROTEIN S6 KINASE RIBOSOMAL PROTEIN S6 KINASE ALPHA-5 protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740 cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;signaling#GO:0023052;regulation of DNA-templated transcription#GO:0006355;TORC1 signaling#GO:0038202;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of nucleobase-containing compound metabolic process#GO:0019219;TOR signaling#GO:0031929;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 protein modifying enzyme#PC00260 Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>P90 RSK#P00888;p38 MAPK pathway#P05918>MSK1#P06040;PDGF signaling pathway#P00047>p90RSK#P01142 HUMAN|HGNC=5295|UniProtKB=P28335 P28335 HTR2C PTHR24247:SF32 5-HYDROXYTRYPTAMINE RECEPTOR 5-HYDROXYTRYPTAMINE RECEPTOR 2C transmembrane signaling receptor activity#GO:0004888;G protein-coupled amine receptor activity#GO:0008227;neurotransmitter receptor activity#GO:0030594;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089 signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987;synaptic signaling#GO:0099536;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;response to chemical#GO:0042221;cellular response to nitrogen compound#GO:1901699;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;chemical synaptic transmission#GO:0007268;signaling#GO:0023052;response to stimulus#GO:0050896;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;response to oxygen-containing compound#GO:1901700;G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887;trans-synaptic signaling#GO:0099537;response to nitrogen compound#GO:1901698;cell communication#GO:0007154 dendrite#GO:0030425;dendritic tree#GO:0097447;membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005;cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;cell projection#GO:0042995 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GsPCR#P00720;5HT2 type receptor mediated signaling pathway#P04374>5HT2 Receptor#P04414 HUMAN|HGNC=29244|UniProtKB=Q68DU8 Q68DU8 KCTD16 PTHR14499:SF28 POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD16 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;multicellular organismal process#GO:0032501;regulation of cell communication#GO:0010646;nervous system development#GO:0007399;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;animal gross anatomical part developmental process#GO:0160108;regulation of G protein-coupled receptor signaling pathway#GO:0008277;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;developmental process#GO:0032502;anatomical structure development#GO:0048856;multicellular organism development#GO:0007275;system development#GO:0048731 postsynaptic membrane#GO:0045211;synapse#GO:0045202;cellular anatomical structure#GO:0110165;postsynapse#GO:0098794;presynaptic active zone membrane#GO:0048787;presynaptic active zone#GO:0048786;cell junction#GO:0030054;signaling receptor complex#GO:0043235;synaptic membrane#GO:0097060;presynaptic membrane#GO:0042734;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;plasma membrane region#GO:0098590;cell periphery#GO:0071944;presynapse#GO:0098793;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HUMAN|HGNC=30221|UniProtKB=Q9BSL1 Q9BSL1 UBAC1 PTHR46738:SF1 UBIQUITIN-ASSOCIATED DOMAIN-CONTAINING PROTEIN 1 UBIQUITIN-ASSOCIATED DOMAIN-CONTAINING PROTEIN 1 ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;intracellular protein-containing complex#GO:0140535;catalytic complex#GO:1902494;transferase complex#GO:1990234 HUMAN|HGNC=7821|UniProtKB=P14543 P14543 NID1 PTHR46513:SF6 VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED NIDOGEN-1 transmembrane signal receptor#PC00197 HUMAN|HGNC=18360|UniProtKB=Q92551 Q92551 IP6K1 PTHR12400:SF73 INOSITOL POLYPHOSPHATE KINASE INOSITOL HEXAKISPHOSPHATE KINASE 1 phosphotransferase activity, phosphate group as acceptor#GO:0016776;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740 phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phospholipid metabolic process#GO:0006644;glycerolipid metabolic process#GO:0046486;small molecule metabolic process#GO:0044281;phospholipid biosynthetic process#GO:0008654;phosphatidylinositol phosphate biosynthetic process#GO:0046854;organophosphate biosynthetic process#GO:0090407;alcohol biosynthetic process#GO:0046165;glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;biosynthetic process#GO:0009058;glycerophospholipid metabolic process#GO:0006650;lipid biosynthetic process#GO:0008610;glycerophospholipid biosynthetic process#GO:0046474;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152;alcohol metabolic process#GO:0006066 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 kinase#PC00137 HUMAN|HGNC=10710|UniProtKB=P0DI82 P0DI82 TRAPPC2B PTHR12403:SF1 TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2 TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2-RELATED intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;transport#GO:0006810;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;endosomal transport#GO:0016197;retrograde transport, endosome to Golgi#GO:0042147;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;cytosolic transport#GO:0016482 membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;TRAPPII protein complex#GO:1990071;intracellular vesicle#GO:0097708;vesicle tethering complex#GO:0099023;intracellular protein-containing complex#GO:0140535;Golgi apparatus#GO:0005794;TRAPP complex#GO:0030008;cytoplasm#GO:0005737;endomembrane system#GO:0012505;protein-containing complex#GO:0032991 membrane traffic protein#PC00150 HUMAN|HGNC=30527|UniProtKB=Q8IXP5 Q8IXP5 POU2AF2 PTHR28376:SF1 RGD1562914 POU DOMAIN CLASS 2-ASSOCIATING FACTOR 2 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;nucleic acid binding#GO:0003676;binding#GO:0005488;sequence-specific DNA binding#GO:0043565;transcription coactivator activity#GO:0003713;DNA binding#GO:0003677 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=11299|UniProtKB=P37108 P37108 SRP14 PTHR12013:SF2 SIGNAL RECOGNITION PARTICLE 14 KD PROTEIN SIGNAL RECOGNITION PARTICLE 14 KDA PROTEIN intracellular transport#GO:0046907;protein targeting to membrane#GO:0006612;protein transmembrane transport#GO:0071806;SRP-dependent cotranslational protein targeting to membrane#GO:0006614;transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular protein transmembrane transport#GO:0065002;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;protein targeting to ER#GO:0045047;intracellular protein localization#GO:0008104;establishment of protein localization to membrane#GO:0090150;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;establishment of protein localization to endoplasmic reticulum#GO:0072599;localization within membrane#GO:0051668;cellular localization#GO:0051641;transmembrane transport#GO:0055085;localization#GO:0051179;protein transport#GO:0015031;protein targeting#GO:0006605 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;signal recognition particle, endoplasmic reticulum targeting#GO:0005786;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HUMAN|HGNC=16096|UniProtKB=Q96N03 Q96N03 VSTM2L PTHR12207:SF31 V-SET AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN V-SET AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 2-LIKE PROTEIN cellular anatomical structure#GO:0110165;membrane#GO:0016020 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=19891|UniProtKB=Q86UT5 Q86UT5 NHERF4 PTHR14191:SF20 PDZ DOMAIN CONTAINING PROTEIN NA(+)_H(+) EXCHANGE REGULATORY COFACTOR NHE-RF4 protein binding#GO:0005515;protein-membrane adaptor activity#GO:0043495;signaling receptor binding#GO:0005102;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 localization within membrane#GO:0051668;protein localization to cell periphery#GO:1990778;intracellular protein localization#GO:0008104;cellular localization#GO:0051641;localization#GO:0051179;cellular process#GO:0009987;protein localization to plasma membrane#GO:0072659;protein localization to membrane#GO:0072657;macromolecule localization#GO:0033036 apical plasma membrane#GO:0016324;membrane#GO:0016020;apical part of cell#GO:0045177;cell periphery#GO:0071944;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HUMAN|HGNC=5330|UniProtKB=P41252 P41252 IARS1 PTHR42780:SF1 SOLEUCYL-TRNA SYNTHETASE ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;ligase activity#GO:0016874;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a tRNA#GO:0140101 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;protein biosynthetic process#GO:0160307;translation#GO:0006412;RNA metabolic process#GO:0016070;protein metabolic process#GO:0019538;tRNA aminoacylation#GO:0043039;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;tRNA aminoacylation for protein translation#GO:0006418;gene expression#GO:0010467;amino acid metabolic process#GO:0006520;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;amino acid activation#GO:0043038;macromolecule metabolic process#GO:0043170 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;cytosol#GO:0005829;catalytic complex#GO:1902494 aminoacyl-tRNA synthetase#PC00047 HUMAN|HGNC=23303|UniProtKB=Q8NG11 Q8NG11 TSPAN14 PTHR19282:SF261 TETRASPANIN TETRASPANIN-14 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HUMAN|HGNC=29323|UniProtKB=Q6ZS81 Q6ZS81 WDFY4 PTHR46108:SF3 BLUE CHEESE WD REPEAT- AND FYVE DOMAIN-CONTAINING PROTEIN 4 immune system process#GO:0002376;antigen processing and presentation#GO:0019882 HUMAN|HGNC=12668|UniProtKB=O14598 O14598 VCY PTHR15251:SF3 TESTIS-SPECIFIC BASIC PROTEIN Y 1-RELATED TESTIS-SPECIFIC BASIC PROTEIN Y 1-RELATED animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502;animal organ development#GO:0048513;anatomical structure development#GO:0048856;multicellular organism development#GO:0007275;system development#GO:0048731;multicellular organismal process#GO:0032501;brain development#GO:0007420;central nervous system development#GO:0007417;head development#GO:0060322;nervous system development#GO:0007399 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=13499|UniProtKB=Q3ZCT1 Q3ZCT1 ZNF260 PTHR24377:SF778 IP01015P-RELATED ZINC FINGER PROTEIN 260 DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=7555|UniProtKB=P12524 P12524 MYCL PTHR45851:SF5 MYC PROTO-ONCOGENE PROTEIN L-MYC-RELATED nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 Wnt signaling pathway#P00057>Wnt Target Genes#G01558 HUMAN|HGNC=12559|UniProtKB=P07911 P07911 UMOD PTHR14002:SF40 ENDOGLIN/TGF-BETA RECEPTOR TYPE III UROMODULIN myeloid leukocyte migration#GO:0097529;leukocyte migration#GO:0050900;immune system process#GO:0002376;neutrophil migration#GO:1990266;granulocyte migration#GO:0097530;cell migration#GO:0016477;cell motility#GO:0048870;cellular process#GO:0009987 cell periphery#GO:0071944;apical plasma membrane#GO:0016324;membrane#GO:0016020;plasma membrane#GO:0005886;cell surface#GO:0009986;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;apical part of cell#GO:0045177;extracellular region#GO:0005576 transmembrane signal receptor#PC00197 HUMAN|HGNC=20663|UniProtKB=Q6KCM7 Q6KCM7 SLC25A25 PTHR24089:SF762 SOLUTE CARRIER FAMILY 25 MITOCHONDRIAL ADENYL NUCLEOTIDE ANTIPORTER SLC25A25 phosphate transmembrane transporter activity#GO:0005315;nucleobase-containing compound transmembrane transporter activity#GO:0015932;organophosphate ester transmembrane transporter activity#GO:0015605;carbohydrate derivative transmembrane transporter activity#GO:1901505;antiporter activity#GO:0015297;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;purine nucleotide transmembrane transporter activity#GO:0015216;active transmembrane transporter activity#GO:0022804 carbohydrate derivative transport#GO:1901264;transport#GO:0006810;nitrogen compound transport#GO:0071705;localization#GO:0051179;organophosphate ester transport#GO:0015748;nucleobase-containing compound transport#GO:0015931;establishment of localization#GO:0051234 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 secondary carrier transporter#PC00258;mitochondrial carrier protein#PC00158 HUMAN|HGNC=10925|UniProtKB=O15374 O15374 SLC16A4 PTHR11360:SF14 MONOCARBOXYLATE TRANSPORTER MONOCARBOXYLATE TRANSPORTER 5-RELATED monocarboxylic acid transmembrane transporter activity#GO:0008028;carboxylic acid transmembrane transporter activity#GO:0046943;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227 HUMAN|HGNC=4888|UniProtKB=Q03591 Q03591 CFHR1 PTHR45785:SF12 COMPLEMENT FACTOR H-RELATED COMPLEMENT FACTOR H-RELATED PROTEIN 1-RELATED complement binding#GO:0001848;binding#GO:0005488;protein binding#GO:0005515 immune system process#GO:0002376;regulation of immune response#GO:0050776;regulation of immune system process#GO:0002682;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;humoral immune response#GO:0006959;immune effector process#GO:0002252;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;positive regulation of immune system process#GO:0002684;immune response#GO:0006955;positive regulation of biological process#GO:0048518;complement activation#GO:0006956;activation of immune response#GO:0002253 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 complement component#PC00078 HUMAN|HGNC=21900|UniProtKB=Q9NXW9 Q9NXW9 ALKBH4 PTHR12463:SF0 OXYGENASE-RELATED ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 4 oxidoreductase activity#GO:0016491;demethylase activity#GO:0032451;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;dioxygenase activity#GO:0051213;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824 actin filament-based process#GO:0030029;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;actomyosin structure organization#GO:0031032;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036 cellular anatomical structure#GO:0110165;midbody#GO:0030496;contractile ring#GO:0070938 oxidoreductase#PC00176;oxygenase#PC00177 HUMAN|HGNC=23492|UniProtKB=Q17RR3 Q17RR3 PNLIPRP3 PTHR11610:SF100 LIPASE PANCREATIC LIPASE-RELATED PROTEIN 3 catalytic activity#GO:0003824;lipase activity#GO:0016298;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787 primary metabolic process#GO:0044238;metabolic process#GO:0008152;cellular process#GO:0009987;lipid metabolic process#GO:0006629;lipid catabolic process#GO:0016042;catabolic process#GO:0009056 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 hydrolase#PC00121;metabolite interconversion enzyme#PC00262;lipase#PC00143 HUMAN|HGNC=9163|UniProtKB=Q13519 Q13519 PNOC PTHR11438:SF2 PROENKEPHALIN PREPRONOCICEPTIN molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;G protein-coupled receptor binding#GO:0001664;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;molecular function activator activity#GO:0140677;protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 system process#GO:0003008;cellular process#GO:0009987;signal transduction#GO:0007165;synaptic signaling#GO:0099536;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;nervous system process#GO:0050877;sensory perception#GO:0007600;trans-synaptic signaling#GO:0099537;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;neuropeptide signaling pathway#GO:0007218;chemical synaptic transmission#GO:0007268;sensory perception of pain#GO:0019233;signaling#GO:0023052;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;response to stimulus#GO:0050896 cell body#GO:0044297;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;neuronal cell body#GO:0043025;somatodendritic compartment#GO:0036477;plasma membrane region#GO:0098590;synapse#GO:0045202;cellular anatomical structure#GO:0110165;synaptic membrane#GO:0097060;cell junction#GO:0030054 neuropeptide#PC00162;peptide hormone#PC00179;intercellular signal molecule#PC00207 HUMAN|HGNC=13478|UniProtKB=Q7Z3V4 Q7Z3V4 UBE3B PTHR45700:SF3 UBIQUITIN-PROTEIN LIGASE E3C UBIQUITIN-PROTEIN LIGASE E3B aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746 protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;cellular process#GO:0009987;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;catabolic process#GO:0009056;modification-dependent protein catabolic process#GO:0019941;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein modification by small protein conjugation or removal#GO:0070647 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 Ubiquitin proteasome pathway#P00060>E3#P01490 HUMAN|HGNC=16467|UniProtKB=Q15027 Q15027 ACAP1 PTHR23180:SF197 CENTAURIN/ARF ARF-GAP WITH COILED-COIL, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 1 enzyme activator activity#GO:0008047;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234 cytoskeleton organization#GO:0007010;cellular component organization or biogenesis#GO:0071840;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987;actin filament-based process#GO:0030029;organelle organization#GO:0006996;cellular component organization#GO:0016043 vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;endosome#GO:0005768;endosome membrane#GO:0010008;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cell periphery#GO:0071944;membrane#GO:0016020;vesicle membrane#GO:0012506;cytoplasm#GO:0005737;plasma membrane#GO:0005886;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588 HUMAN|HGNC=23571|UniProtKB=Q53SF7 Q53SF7 COBLL1 PTHR21557:SF2 CORDON-BLEU CORDON-BLEU PROTEIN-LIKE 1 HUMAN|HGNC=11296|UniProtKB=P19623 P19623 SRM PTHR11558:SF11 SPERMIDINE/SPERMINE SYNTHASE SPERMIDINE SYNTHASE transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;catalytic activity#GO:0003824;transferase activity#GO:0016740 biogenic amine metabolic process#GO:0006576;biosynthetic process#GO:0009058;polyamine biosynthetic process#GO:0006596;cellular process#GO:0009987;polyamine metabolic process#GO:0006595;amine metabolic process#GO:0009308;metabolic process#GO:0008152 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 transferase#PC00220 HUMAN|HGNC=21113|UniProtKB=Q6UY11 Q6UY11 DLK2 PTHR24044:SF423 NOTCH LIGAND FAMILY MEMBER PROTEIN DELTA HOMOLOG 2 protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488 intercellular signal molecule#PC00207 HUMAN|HGNC=16754|UniProtKB=Q96P50 Q96P50 ACAP3 PTHR23180:SF407 CENTAURIN/ARF ARF-GAP WITH COILED-COIL, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 3 enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme activator activity#GO:0008047 cell migration#GO:0016477;multicellular organismal process#GO:0032501;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;nervous system development#GO:0007399;organelle organization#GO:0006996;regulation of neuron projection development#GO:0010975;cellular process#GO:0009987;regulation of plasma membrane bounded cell projection organization#GO:0120035;neuron migration#GO:0001764;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;regulation of cell projection organization#GO:0031344;developmental process#GO:0032502;regulation of cellular component organization#GO:0051128;cell differentiation#GO:0030154;cell motility#GO:0048870;regulation of cellular process#GO:0050794;actin cytoskeleton organization#GO:0030036;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;anatomical structure development#GO:0048856;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;actin filament-based process#GO:0030029 intracellular organelle#GO:0043229;endosome membrane#GO:0010008;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;cell periphery#GO:0071944;vesicle membrane#GO:0012506;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505 HUMAN|HGNC=12984|UniProtKB=O15535 O15535 ZSCAN9 PTHR23226:SF15 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 9 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=12429|UniProtKB=Q9GZX9 Q9GZX9 TWSG1 PTHR12312:SF17 TWISTED GASTRULATION PROTEIN HOMOLOG 1-A-RELATED TWISTED GASTRULATION PROTEIN HOMOLOG 1 regulation of cell communication#GO:0010646;regulation of cellular response to growth factor stimulus#GO:0090287;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of BMP signaling pathway#GO:0030510;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=21732|UniProtKB=P58335 P58335 ANTXR2 PTHR16059:SF13 ANTHRAX TOXIN RECEPTOR ANTHRAX TOXIN RECEPTOR 2 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;plasma membrane#GO:0005886 cell adhesion molecule#PC00069 HUMAN|HGNC=18459|UniProtKB=Q9NXF8 Q9NXF8 ZDHHC7 PTHR22883:SF49 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE ZDHHC7 acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;regulation of G protein-coupled receptor signaling pathway#GO:0008277;regulation of response to stimulus#GO:0048583;protein localization to cell periphery#GO:1990778;protein targeting to membrane#GO:0006612;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;cellular process#GO:0009987;establishment of protein localization#GO:0045184;macromolecule localization#GO:0033036;establishment of protein localization to membrane#GO:0090150;cellular localization#GO:0051641;localization#GO:0051179;regulation of signaling#GO:0023051;localization within membrane#GO:0051668;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;protein targeting#GO:0006605;regulation of biological process#GO:0050789;protein localization to plasma membrane#GO:0072659;protein localization to membrane#GO:0072657 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HUMAN|HGNC=12734|UniProtKB=Q9UPY6 Q9UPY6 WASF3 PTHR12902:SF7 WASP-1 ACTIN-BINDING PROTEIN WASF3 protein binding#GO:0005515;protein-containing complex binding#GO:0044877;protein kinase A binding#GO:0051018;binding#GO:0005488;protein kinase A regulatory subunit binding#GO:0034237 cellular component organization or biogenesis#GO:0071840;regulation of actin filament-based process#GO:0032970;regulation of actin nucleation#GO:0051125;regulation of actin cytoskeleton organization#GO:0032956;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;regulation of actin filament organization#GO:0110053;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;organelle organization#GO:0006996;positive regulation of organelle organization#GO:0010638;actin filament-based process#GO:0030029;positive regulation of cellular component organization#GO:0051130;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;regulation of organelle organization#GO:0033043;regulation of supramolecular fiber organization#GO:1902903;regulation of biological process#GO:0050789;cellular component organization#GO:0016043 intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;lamellipodium#GO:0030027;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;cell projection#GO:0042995;cell leading edge#GO:0031252 cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165;actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=10007|UniProtKB=O75783 O75783 RHBDL1 PTHR45840:SF4 RHOMBOID-RELATED PROTEIN RHOMBOID-RELATED PROTEIN 1 catalytic activity#GO:0003824;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171 HUMAN|HGNC=37253|UniProtKB=Q6ZV50 Q6ZV50 RFX8 PTHR12619:SF24 RFX TRANSCRIPTION FACTOR FAMILY DNA-BINDING PROTEIN RFX8 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 winged helix/forkhead transcription factor#PC00246 HUMAN|HGNC=4485|UniProtKB=Q99527 Q99527 GPER1 PTHR24226:SF2 G-PROTEIN COUPLED RECEPTOR 182 AND ESTROGEN RECEPTOR 1 G PROTEIN-COUPLED ESTROGEN RECEPTOR 1 G protein-coupled receptor activity#GO:0004930;steroid binding#GO:0005496;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;nuclear receptor activity#GO:0004879;lipid binding#GO:0008289;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulator activity#GO:0140110;transmembrane signaling receptor activity#GO:0004888 cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular response to oxygen-containing compound#GO:1901701;response to hormone#GO:0009725;response to estradiol#GO:0032355;cellular response to lipid#GO:0071396;response to lipid#GO:0033993;response to chemical#GO:0042221;regulation of ERK1 and ERK2 cascade#GO:0070372;regulation of MAPK cascade#GO:0043408;cellular response to steroid hormone stimulus#GO:0071383;regulation of biological process#GO:0050789;estrogen receptor signaling pathway#GO:0030520;response to endogenous stimulus#GO:0009719;signaling#GO:0023052;regulation of cell cycle#GO:0051726;cellular response to hormone stimulus#GO:0032870;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;regulation of signaling#GO:0023051;response to oxygen-containing compound#GO:1901700;regulation of intracellular signal transduction#GO:1902531;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;positive regulation of signaling#GO:0023056;hormone-mediated signaling pathway#GO:0009755;positive regulation of cellular process#GO:0048522;nuclear receptor-mediated steroid hormone signaling pathway#GO:0030518;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;nuclear receptor-mediated signaling pathway#GO:0141193;positive regulation of response to stimulus#GO:0048584;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of MAPK cascade#GO:0043410;cellular response to stimulus#GO:0051716;steroid hormone receptor signaling pathway#GO:0043401;positive regulation of signal transduction#GO:0009967;positive regulation of ERK1 and ERK2 cascade#GO:0070374;regulation of cell communication#GO:0010646;intracellular receptor signaling pathway#GO:0030522;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;response to steroid hormone#GO:0048545;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cell periphery#GO:0071944;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 G-protein coupled receptor#PC00021 HUMAN|HGNC=17258|UniProtKB=Q9UPW5 Q9UPW5 AGTPBP1 PTHR12756:SF24 CYTOSOLIC CARBOXYPEPTIDASE CYTOSOLIC CARBOXYPEPTIDASE 1 catalytic activity#GO:0003824;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;metalloexopeptidase activity#GO:0008235;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;binding#GO:0005488;metallopeptidase activity#GO:0008237;exopeptidase activity#GO:0008238;hydrolase activity#GO:0016787;protein binding#GO:0005515;metallocarboxypeptidase activity#GO:0004181;carboxypeptidase activity#GO:0004180 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;microtubule cytoskeleton#GO:0015630;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 metalloprotease#PC00153 HUMAN|HGNC=26488|UniProtKB=A6PVL3 A6PVL3 KNCN PTHR38497:SF1 KINOCILIN KINOCILIN cilium#GO:0005929;intracellular organelle#GO:0043229;cluster of actin-based cell projections#GO:0098862;membrane-bounded organelle#GO:0043227;non-motile cilium#GO:0097730;intracellular anatomical structure#GO:0005622;actin cytoskeleton#GO:0015629;apical plasma membrane#GO:0016324;cortical cytoskeleton#GO:0030863;cell cortex#GO:0005938;cell body#GO:0044297;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;neuronal cell body#GO:0043025;plasma membrane bounded cell projection#GO:0120025;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;ciliary basal body#GO:0036064;apical part of cell#GO:0045177;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;plasma membrane region#GO:0098590;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;cytoplasm#GO:0005737;cortical actin cytoskeleton#GO:0030864 HUMAN|HGNC=15391|UniProtKB=Q8NG97 Q8NG97 OR2Z1 PTHR26453:SF96 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2Z1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 system process#GO:0003008;nervous system process#GO:0050877;sensory perception#GO:0007600;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;response to stimulus#GO:0050896;response to chemical#GO:0042221;detection of chemical stimulus#GO:0009593;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=29865|UniProtKB=Q9Y3E7 Q9Y3E7 CHMP3 PTHR10476:SF1 CHARGED MULTIVESICULAR BODY PROTEIN CHARGED MULTIVESICULAR BODY PROTEIN 3 intracellular transport#GO:0046907;vacuolar transport#GO:0007034;transport#GO:0006810;establishment of localization#GO:0051234;endosomal transport#GO:0016197;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;multivesicular body sorting pathway#GO:0071985;endosome transport via multivesicular body sorting pathway#GO:0032509;vesicle-mediated transport#GO:0016192;localization#GO:0051179;cellular localization#GO:0051641;protein transport#GO:0015031;late endosome to vacuole transport#GO:0045324 intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;endosome membrane#GO:0010008;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;vesicle#GO:0031982;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;late endosome#GO:0005770;endomembrane system#GO:0012505;cytoplasm#GO:0005737;membrane#GO:0016020;vesicle membrane#GO:0012506 membrane traffic protein#PC00150 HUMAN|HGNC=7415|UniProtKB=P03928 P03928 MT-ATP8 PTHR13722:SF0 ATP SYNTHASE PROTEIN 8 ATP SYNTHASE F(0) COMPLEX SUBUNIT 8 channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;proton-transporting ATP synthase activity, rotational mechanism#GO:0046933;passive transmembrane transporter activity#GO:0022803;proton transmembrane transporter activity#GO:0015078;catalytic activity#GO:0003824;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;ligase activity#GO:0016874;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261;proton channel activity#GO:0015252 small molecule metabolic process#GO:0044281;purine-containing compound metabolic process#GO:0072521;proton motive force-driven mitochondrial ATP synthesis#GO:0042776;purine nucleotide metabolic process#GO:0006163;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;ribonucleotide metabolic process#GO:0009259;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;ribose phosphate metabolic process#GO:0019693;ATP metabolic process#GO:0046034;cellular process#GO:0009987;ribose phosphate biosynthetic process#GO:0046390;nucleobase-containing small molecule metabolic process#GO:0055086;ribonucleoside triphosphate biosynthetic process#GO:0009201;carbohydrate derivative biosynthetic process#GO:1901137;ATP biosynthetic process#GO:0006754;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;nucleoside phosphate metabolic process#GO:0006753;nucleoside triphosphate metabolic process#GO:0009141;proton motive force-driven ATP synthesis#GO:0015986;purine nucleoside triphosphate biosynthetic process#GO:0009145;purine nucleoside triphosphate metabolic process#GO:0009144;primary metabolic process#GO:0044238;aerobic respiration#GO:0009060;cellular respiration#GO:0045333;organophosphate biosynthetic process#GO:0090407;oxidative phosphorylation#GO:0006119;purine ribonucleoside triphosphate biosynthetic process#GO:0009206;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;purine ribonucleoside triphosphate metabolic process#GO:0009205;carbohydrate derivative metabolic process#GO:1901135;nucleoside triphosphate biosynthetic process#GO:0009142;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;energy derivation by oxidation of organic compounds#GO:0015980;nucleoside phosphate biosynthetic process#GO:1901293;generation of precursor metabolites and energy#GO:0006091 proton-transporting ATP synthase complex#GO:0045259;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;respiratory chain complex#GO:0098803;membrane protein complex#GO:0098796;membrane#GO:0016020;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;catalytic complex#GO:1902494;cation channel complex#GO:0034703;proton-transporting two-sector ATPase complex#GO:0016469 ATP synthase#PC00002 HUMAN|HGNC=7955|UniProtKB=P01303 P01303 NPY PTHR10533:SF5 NEUROPEPTIDE Y/PANCREATIC HORMONE/PEPTIDE YY PRO-NEUROPEPTIDE Y protein binding#GO:0005515;molecular function activator activity#GO:0140677;hormone activity#GO:0005179;signaling receptor binding#GO:0005102;binding#GO:0005488;neuropeptide hormone activity#GO:0005184;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;neuropeptide receptor binding#GO:0071855;G protein-coupled receptor binding#GO:0001664 response to stimulus#GO:0050896;multicellular organismal process#GO:0032501;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;neuropeptide signaling pathway#GO:0007218;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;feeding behavior#GO:0007631;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HUMAN|HGNC=34550|UniProtKB=A6NGN9 A6NGN9 IGLON5 PTHR42757:SF12 IGLON FAMILY OF IMMUNOGLOBULIN SUPERFAMILY-RELATED IGLON FAMILY MEMBER 5 regulation of cellular process#GO:0050794;regulation of synapse assembly#GO:0051963;regulation of cellular component organization#GO:0051128;regulation of cellular component biogenesis#GO:0044087;biological regulation#GO:0065007;cell-cell adhesion#GO:0098609;heterophilic cell-cell adhesion#GO:0007157;cellular process#GO:0009987;regulation of biological process#GO:0050789;regulation of synapse structure or activity#GO:0050803;regulation of biological quality#GO:0065008;regulation of synapse organization#GO:0050807;regulation of cell junction assembly#GO:1901888;cell adhesion#GO:0007155 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 immunoglobulin#PC00123 HUMAN|HGNC=16067|UniProtKB=Q8IZQ8 Q8IZQ8 MYOCD PTHR22793:SF11 MYOCARDIN-RELATED TRANSCRIPTION FACTOR-RELATED MYOCARDIN anatomical structure development#GO:0048856;muscle tissue development#GO:0060537;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;circulatory system development#GO:0072359;cell differentiation#GO:0030154;muscle structure development#GO:0061061;muscle cell differentiation#GO:0042692;multicellular organism development#GO:0007275;animal organ development#GO:0048513;cellular developmental process#GO:0048869;cardiac muscle tissue development#GO:0048738;striated muscle cell differentiation#GO:0051146;developmental process#GO:0032502;striated muscle tissue development#GO:0014706;heart development#GO:0007507;multicellular organismal process#GO:0032501;tissue development#GO:0009888;cardiac muscle cell differentiation#GO:0055007;cellular process#GO:0009987 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HUMAN|HGNC=21405|UniProtKB=Q8IYR0 Q8IYR0 CFAP206 PTHR21442:SF1 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 206 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 206 cell development#GO:0048468;cellular process involved in reproduction in multicellular organism#GO:0022412;gamete generation#GO:0007276;regulation of microtubule-based movement#GO:0060632;cell projection organization#GO:0030030;cell differentiation#GO:0030154;sperm motility#GO:0097722;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cilium organization#GO:0044782;sperm flagellum assembly#GO:0120316;cilium-dependent cell motility#GO:0060285;cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;spermatid differentiation#GO:0048515;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;cellular process#GO:0009987;cell projection assembly#GO:0030031;cilium movement involved in cell motility#GO:0060294;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;microtubule-based process#GO:0007017;motile cilium assembly#GO:0044458;cellular component organization or biogenesis#GO:0071840;reproductive process#GO:0022414;regulation of cellular process#GO:0050794;microtubule-based movement#GO:0007018;cell motility#GO:0048870;germ cell development#GO:0007281;developmental process involved in reproduction#GO:0003006;multicellular organismal reproductive process#GO:0048609;axoneme assembly#GO:0035082;microtubule cytoskeleton organization#GO:0000226;anatomical structure development#GO:0048856;regulation of cell motility#GO:2000145;microtubule bundle formation#GO:0001578;spermatid development#GO:0007286;sexual reproduction#GO:0019953;regulation of microtubule-based process#GO:0032886;organelle assembly#GO:0070925;regulation of locomotion#GO:0040012;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;male gamete generation#GO:0048232;regulation of reproductive process#GO:2000241;sperm axoneme assembly#GO:0007288;cellular developmental process#GO:0048869;developmental process#GO:0032502;spermatogenesis#GO:0007283;plasma membrane bounded cell projection assembly#GO:0120031;flagellated sperm motility#GO:0030317 ciliary plasm#GO:0097014;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;axoneme#GO:0005930;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cilium#GO:0005929;intracellular organelle#GO:0043229 HUMAN|HGNC=13358|UniProtKB=Q8TDD5 Q8TDD5 MCOLN3 PTHR12127:SF5 MUCOLIPIN MUCOLIPIN-3 transporter activity#GO:0005215;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;gated channel activity#GO:0022836;monoatomic cation transmembrane transporter activity#GO:0008324;ligand-gated calcium channel activity#GO:0099604;calcium ion transmembrane transporter activity#GO:0015085;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;monoatomic cation channel activity#GO:0005261;ligand-gated monoatomic ion channel activity#GO:0015276;channel activity#GO:0015267 bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;vacuolar membrane#GO:0005774;lytic vacuole#GO:0000323;cytoplasm#GO:0005737;plasma membrane#GO:0005886;vacuole#GO:0005773;cell periphery#GO:0071944;lysosomal membrane#GO:0005765;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;lysosome#GO:0005764;lytic vacuole membrane#GO:0098852 transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=23536|UniProtKB=Q9UQQ1 Q9UQQ1 NAALADL1 PTHR10404:SF50 N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE AMINOPEPTIDASE NAALADL1 peptidase activity#GO:0008233;carboxypeptidase activity#GO:0004180;catalytic activity, acting on a protein#GO:0140096;exopeptidase activity#GO:0008238;hydrolase activity#GO:0016787;catalytic activity#GO:0003824 metalloprotease#PC00153 HUMAN|HGNC=20296|UniProtKB=Q9Y2H6 Q9Y2H6 FNDC3A PTHR24099:SF9 E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN 3A anatomical structure development#GO:0048856;multicellular organismal reproductive process#GO:0048609;spermatid differentiation#GO:0048515;spermatid development#GO:0007286;sexual reproduction#GO:0019953;gamete generation#GO:0007276;cell differentiation#GO:0030154;cellular process involved in reproduction in multicellular organism#GO:0022412;cell development#GO:0048468;reproductive process#GO:0022414;developmental process involved in reproduction#GO:0003006;germ cell development#GO:0007281;cellular developmental process#GO:0048869;developmental process#GO:0032502;spermatogenesis#GO:0007283;male gamete generation#GO:0048232;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=30915|UniProtKB=P61962 P61962 DCAF7 PTHR19919:SF0 WD REPEAT CONTAINING PROTEIN DDB1- AND CUL4-ASSOCIATED FACTOR 7 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=26101|UniProtKB=Q96CM8 Q96CM8 ACSF2 PTHR43201:SF5 ACYL-COA SYNTHETASE MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL ligase activity, forming carbon-sulfur bonds#GO:0016877;catalytic activity#GO:0003824;ligase activity#GO:0016874;ATP-dependent activity#GO:0140657 small molecule metabolic process#GO:0044281;cellular process#GO:0009987;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;lipid metabolic process#GO:0006629;fatty acid metabolic process#GO:0006631;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152 ligase#PC00142;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=2648|UniProtKB=P98187 P98187 CYP4F8 PTHR24291:SF192 CYTOCHROME P450 FAMILY 4 CYTOCHROME P450 4F8 icosanoid metabolic process#GO:0006690;long-chain fatty acid metabolic process#GO:0001676;cellular process#GO:0009987;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;unsaturated fatty acid metabolic process#GO:0033559;lipid metabolic process#GO:0006629;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;small molecule catabolic process#GO:0044282;monocarboxylic acid metabolic process#GO:0032787;ketone metabolic process#GO:0042180;vitamin K metabolic process#GO:0042373;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;arachidonate metabolic process#GO:0019369;oxoacid metabolic process#GO:0043436;olefinic compound metabolic process#GO:0120254 metabolite interconversion enzyme#PC00262;oxygenase#PC00177;oxidoreductase#PC00176 HUMAN|HGNC=18802|UniProtKB=Q8N5M1 Q8N5M1 ATPAF2 PTHR21013:SF10 ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2/ATP12 PROTEIN, MITOCHONDRIAL PRECURSOR ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2 chaperone#PC00072 HUMAN|HGNC=2475|UniProtKB=P01034 P01034 CST3 PTHR46186:SF10 CYSTATIN CYSTATIN-C molecular function inhibitor activity#GO:0140678;cysteine-type endopeptidase inhibitor activity#GO:0004869;enzyme regulator activity#GO:0030234;peptidase regulator activity#GO:0061134;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866;enzyme inhibitor activity#GO:0004857 extracellular region#GO:0005576;vesicle#GO:0031982;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 protease inhibitor#PC00191 HUMAN|HGNC=19075|UniProtKB=Q96CG3 Q96CG3 TIFA PTHR31266:SF2 TRAF-INTERACTING PROTEIN WITH FHA DOMAIN-CONTAINING PROTEIN A FAMILY MEMBER TRAF-INTERACTING PROTEIN WITH FHA DOMAIN-CONTAINING PROTEIN A immune response-regulating signaling pathway#GO:0002764;regulation of biological process#GO:0050789;biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;immune system process#GO:0002376;positive regulation of signaling#GO:0023056;cytoplasmic pattern recognition receptor signaling pathway#GO:0002753;cellular process#GO:0009987;defense response to symbiont#GO:0140546;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;activation of immune response#GO:0002253;positive regulation of immune system process#GO:0002684;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;defense response to other organism#GO:0098542;regulation of response to external stimulus#GO:0032101;positive regulation of response to external stimulus#GO:0032103;positive regulation of canonical NF-kappaB signal transduction#GO:0043123;immune response-activating signaling pathway#GO:0002757;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;innate immune response-activating signaling pathway#GO:0002758;regulation of response to biotic stimulus#GO:0002831;regulation of cell communication#GO:0010646;response to external biotic stimulus#GO:0043207;intracellular receptor signaling pathway#GO:0030522;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of immune system process#GO:0002682;regulation of defense response#GO:0031347;regulation of immune response#GO:0050776;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;positive regulation of innate immune response#GO:0045089;regulation of canonical NF-kappaB signal transduction#GO:0043122;immune response#GO:0006955;positive regulation of cellular process#GO:0048522;activation of innate immune response#GO:0002218;response to other organism#GO:0051707;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of response to stimulus#GO:0048584;regulation of response to stimulus#GO:0048583;positive regulation of defense response#GO:0031349;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of immune response#GO:0050778;regulation of response to stress#GO:0080134;defense response#GO:0006952;pattern recognition receptor signaling pathway#GO:0002221;positive regulation of response to biotic stimulus#GO:0002833;response to external stimulus#GO:0009605;innate immune response#GO:0045087;regulation of innate immune response#GO:0045088 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=4477|UniProtKB=Q99680 Q99680 GPR22 PTHR24241:SF1 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR G PROTEIN-COUPLED RECEPTOR 22 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;cellular response to hormone stimulus#GO:0032870;regulation of cellular process#GO:0050794;signaling#GO:0023052;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to chemical#GO:0042221;biological regulation#GO:0065007;response to hormone#GO:0009725;signal transduction#GO:0007165;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=6604|UniProtKB=Q8N6C8 Q8N6C8 LILRA3 PTHR11738:SF170 MHC CLASS I NK CELL RECEPTOR LEUKOCYTE IMMUNOGLOBULIN-LIKE RECEPTOR SUBFAMILY A MEMBER 3-RELATED transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;immune receptor activity#GO:0140375 cellular response to stimulus#GO:0051716;immune response-regulating signaling pathway#GO:0002764;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;response to stimulus#GO:0050896;signaling#GO:0023052;cytokine-mediated signaling pathway#GO:0019221;regulation of immune response#GO:0050776;cell communication#GO:0007154;response to peptide#GO:1901652;cellular process#GO:0009987;signal transduction#GO:0007165;response to cytokine#GO:0034097;response to chemical#GO:0042221;immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007;regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=10371|UniProtKB=P05388 P05388 RPLP0 PTHR45699:SF1 60S ACIDIC RIBOSOMAL PROTEIN P0 LARGE RIBOSOMAL SUBUNIT PROTEIN UL10-RELATED structural molecule activity#GO:0005198;RNA binding#GO:0003723;nucleic acid binding#GO:0003676;structural constituent of ribosome#GO:0003735;rRNA binding#GO:0019843;binding#GO:0005488 primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;cytoplasmic translation#GO:0002181;biosynthetic process#GO:0009058;metabolic process#GO:0008152;translation#GO:0006412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904 ribosomal protein#PC00202;translational protein#PC00263 HUMAN|HGNC=8766|UniProtKB=Q8WUM4 Q8WUM4 PDCD6IP PTHR23030:SF39 PCD6 INTERACTING PROTEIN-RELATED PROGRAMMED CELL DEATH 6-INTERACTING PROTEIN mitotic cell cycle process#GO:1903047;intracellular protein localization#GO:0008104;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;vacuolar transport#GO:0007034;transport#GO:0006810;intracellular transport#GO:0046907;endosome transport via multivesicular body sorting pathway#GO:0032509;ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043162;late endosome to vacuole transport via multivesicular body sorting pathway#GO:0032511;multivesicular body sorting pathway#GO:0071985;macromolecule localization#GO:0033036;localization#GO:0051179;protein metabolic process#GO:0019538;protein localization to vacuole#GO:0072665;catabolic process#GO:0009056;mitotic cell cycle#GO:0000278;protein localization to organelle#GO:0033365;mitotic cytokinesis#GO:0000281;modification-dependent protein catabolic process#GO:0019941;cell division#GO:0051301;cell cycle#GO:0007049;primary metabolic process#GO:0044238;endosomal transport#GO:0016197;intracellular protein transport#GO:0006886;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;protein transport#GO:0015031;cytoskeleton-dependent cytokinesis#GO:0061640;cellular localization#GO:0051641;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;cytokinesis#GO:0000910;late endosome to vacuole transport#GO:0045324;protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043328;establishment of protein localization to vacuole#GO:0072666;cell cycle process#GO:0022402 intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227 membrane traffic protein#PC00150 HUMAN|HGNC=5137|UniProtKB=P31249 P31249 HOXD3 PTHR45664:SF5 PROTEIN ZERKNUELLT 1-RELATED HOMEOBOX PROTEIN HOX-D3 transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;embryonic organ development#GO:0048568;embryo development ending in birth or egg hatching#GO:0009792;pattern specification process#GO:0007389;animal organ morphogenesis#GO:0009887;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regionalization#GO:0003002;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;skeletal system morphogenesis#GO:0048705;regulation of primary metabolic process#GO:0080090;skeletal system development#GO:0001501;chordate embryonic development#GO:0043009;animal gross anatomical part developmental process#GO:0160108;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;animal organ development#GO:0048513;multicellular organism development#GO:0007275;embryonic morphogenesis#GO:0048598;anterior/posterior pattern specification#GO:0009952;embryo development#GO:0009790 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 homeodomain transcription factor#PC00119 HUMAN|HGNC=9281|UniProtKB=P62136 P62136 PPP1CA PTHR11668:SF377 SERINE/THREONINE PROTEIN PHOSPHATASE SERINE_THREONINE-PROTEIN PHOSPHATASE PP1-ALPHA CATALYTIC SUBUNIT phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721;protein serine/threonine phosphatase activity#GO:0004722 regulation of biological process#GO:0050789;regulation of circadian rhythm#GO:0042752;biological regulation#GO:0065007 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 protein phosphatase#PC00195 Dopamine receptor mediated signaling pathway#P05912>Protein Phosphatase-1#P05969;Nicotine pharmacodynamics pathway#P06587>PPP1CA#P06602 HUMAN|HGNC=44450|UniProtKB=D6RA61 D6RA61 USP17L22 PTHR24006:SF651 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE INACTIVE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 17-LIKE PROTEIN 4-RELATED catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;cysteine-type deubiquitinase activity#GO:0004843;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity, acting on a protein#GO:0140096;deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787 regulation of programmed cell death#GO:0043067;regulation of biological process#GO:0050789;regulation of protein stability#GO:0031647;regulation of apoptotic process#GO:0042981;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of biological quality#GO:0065008 cytosol#GO:0005829;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 cysteine protease#PC00081;protease#PC00190 HUMAN|HGNC=12918|UniProtKB=P52741 P52741 ZNF134 PTHR24399:SF4 ZINC FINGER AND BTB DOMAIN-CONTAINING ZINC FINGER PROTEIN 134 DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulator activity#GO:0140110;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription repressor activity#GO:0001217;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837 negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of cytokine production#GO:0001817;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of multicellular organismal process#GO:0051239;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255 cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=15195|UniProtKB=Q9H255 Q9H255 OR51E2 PTHR26450:SF92 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 51E2 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=32583|UniProtKB=Q6UB28 Q6UB28 METAP1D PTHR43330:SF28 METHIONINE AMINOPEPTIDASE METHIONINE AMINOPEPTIDASE 1D, MITOCHONDRIAL hydrolase activity#GO:0016787;metalloaminopeptidase activity#GO:0070006;exopeptidase activity#GO:0008238;metallopeptidase activity#GO:0008237;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;aminopeptidase activity#GO:0004177;catalytic activity#GO:0003824;metalloexopeptidase activity#GO:0008235 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739 metalloprotease#PC00153 HUMAN|HGNC=8755|UniProtKB=Q9Y5K3 Q9Y5K3 PCYT1B PTHR10739:SF20 CYTIDYLYLTRANSFERASE CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE B phosphatidylcholine binding#GO:0031210;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;phospholipid binding#GO:0005543;transferase activity#GO:0016740;nucleotidyltransferase activity#GO:0016779;lipid binding#GO:0008289;cation binding#GO:0043169;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167 transferase#PC00220 HUMAN|HGNC=16665|UniProtKB=Q9ULZ1 Q9ULZ1 APLN PTHR15953:SF0 APELIN APELIN cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=23715|UniProtKB=Q96K62 Q96K62 ZBTB45 PTHR24399:SF16 ZINC FINGER AND BTB DOMAIN-CONTAINING ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 45 sequence-specific double-stranded DNA binding#GO:1990837;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription repressor activity#GO:0001217;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulator activity#GO:0140110 negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;regulation of multicellular organismal process#GO:0051239;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of cytokine production#GO:0001817 nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 DNA-binding transcription factor#PC00218;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=18743|UniProtKB=Q96PV4 Q96PV4 PNMA5 PTHR23095:SF4 PARANEOPLASTIC ANTIGEN PARANEOPLASTIC ANTIGEN-LIKE PROTEIN 5 transcription cofactor#PC00217 HUMAN|HGNC=16762|UniProtKB=Q2M1K9 Q2M1K9 ZNF423 PTHR24388:SF100 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 423 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=13556|UniProtKB=Q9HBG6 Q9HBG6 IFT122 PTHR12764:SF4 WD REPEAT DOMAIN-RELATED INTRAFLAGELLAR TRANSPORT PROTEIN 122 HOMOLOG intracellular transport#GO:0046907;plasma membrane bounded cell projection assembly#GO:0120031;transport#GO:0006810;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;intracellular protein localization#GO:0008104;cellular component biogenesis#GO:0044085;macromolecule localization#GO:0033036;organelle organization#GO:0006996;cellular process#GO:0009987;cell projection assembly#GO:0030031;establishment of localization in cell#GO:0051649;cytoskeleton-dependent intracellular transport#GO:0030705;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;organelle assembly#GO:0070925;microtubule-based transport#GO:0099111;cellular localization#GO:0051641;localization#GO:0051179;non-motile cilium assembly#GO:1905515;cilium organization#GO:0044782;cilium assembly#GO:0060271;cellular component organization#GO:0016043;protein localization to organelle#GO:0033365;intraciliary retrograde transport#GO:0035721;microtubule-based movement#GO:0007018;cell projection organization#GO:0030030;intraciliary transport#GO:0042073;protein localization to cilium#GO:0061512 cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cilium#GO:0005929;intraciliary transport particle#GO:0030990;membrane-bounded organelle#GO:0043227;intraciliary transport particle A#GO:0030991;non-motile cilium#GO:0097730 HUMAN|HGNC=2959|UniProtKB=Q13609 Q13609 DNASE1L3 PTHR11371:SF32 DEOXYRIBONUCLEASE DEOXYRIBONUCLEASE GAMMA nuclease activity#GO:0004518;DNA binding#GO:0003677;DNA endonuclease activity#GO:0004520;hydrolase activity#GO:0016787;nucleic acid binding#GO:0003676;binding#GO:0005488;endonuclease activity#GO:0004519;catalytic activity, acting on DNA#GO:0140097;hydrolase activity, acting on ester bonds#GO:0016788;DNA nuclease activity#GO:0004536;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;DNA endonuclease activity, producing 5'-phosphomonoesters#GO:0016888 developmental process#GO:0032502;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;macromolecule catabolic process#GO:0009057;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;cellular developmental process#GO:0048869;cellular process#GO:0009987;nucleic acid catabolic process#GO:0141188;nucleobase-containing compound catabolic process#GO:0034655;apoptotic DNA fragmentation#GO:0006309;nucleobase-containing compound metabolic process#GO:0006139;DNA catabolic process#GO:0006308;cellular component disassembly#GO:0022411;anatomical structure development#GO:0048856;execution phase of apoptosis#GO:0097194;apoptotic process#GO:0006915;cell death#GO:0008219;programmed cell death#GO:0012501;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;cell development#GO:0048468;catabolic process#GO:0009056;cell differentiation#GO:0030154 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 endodeoxyribonuclease#PC00093 HUMAN|HGNC=21608|UniProtKB=Q9Y383 Q9Y383 LUC7L2 PTHR12375:SF28 RNA-BINDING PROTEIN LUC7-RELATED RNA-BINDING PROTEIN LUC7-LIKE 2-RELATED RNA binding#GO:0003723;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488 RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;protein-containing complex organization#GO:0043933;protein-RNA complex organization#GO:0071826;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;mRNA processing#GO:0006397;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;mRNA splice site recognition#GO:0006376;gene expression#GO:0010467;cellular component assembly#GO:0022607;spliceosomal complex assembly#GO:0000245;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;protein-RNA complex assembly#GO:0022618;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;mRNA splicing, via spliceosome#GO:0000398;protein-containing complex assembly#GO:0065003;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;ribonucleoprotein complex biogenesis#GO:0022613;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774 protein-containing complex#GO:0032991;U1 snRNP#GO:0005685;small nuclear ribonucleoprotein complex#GO:0030532;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;Sm-like protein family complex#GO:0120114;organelle#GO:0043226;cellular anatomical structure#GO:0110165;U2-type prespliceosome#GO:0071004;intracellular membrane-bounded organelle#GO:0043231;U2-type spliceosomal complex#GO:0005684;spliceosomal complex#GO:0005681;spliceosomal snRNP complex#GO:0097525;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229 HUMAN|HGNC=18664|UniProtKB=Q92520 Q92520 FAM3C PTHR14592:SF10 UNCHARACTERIZED FAM3 PROTEIN FAM3C cytokine activity#GO:0005125;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772 cell communication#GO:0007154;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 antimicrobial response protein#PC00051;defense/immunity protein#PC00090 HUMAN|HGNC=8281|UniProtKB=Q9Y3N9 Q9Y3N9 OR2W1 PTHR26453:SF169 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2W1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 response to stimulus#GO:0050896;response to chemical#GO:0042221;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;detection of chemical stimulus#GO:0009593;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;system process#GO:0003008;sensory perception#GO:0007600;nervous system process#GO:0050877;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=26338|UniProtKB=Q6ZMY3 Q6ZMY3 SPOCD1 PTHR11477:SF18 TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN SPOC DOMAIN-CONTAINING PROTEIN 1 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 regulatory ncRNA-mediated heterochromatin formation#GO:0031048;heterochromatin formation#GO:0031507;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulatory ncRNA-mediated gene silencing#GO:0031047;negative regulation of cellular process#GO:0048523;constitutive heterochromatin formation#GO:0140719;regulation of gene expression#GO:0010468;negative regulation of gene expression, epigenetic#GO:0045814;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;DNA methylation-dependent constitutive heterochromatin formation#GO:0006346;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;epigenetic regulation of gene expression#GO:0040029;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;heterochromatin organization#GO:0070828;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;chromatin organization#GO:0006325;cellular component assembly#GO:0022607 RNA metabolism protein#PC00031;general transcription factor#PC00259 HUMAN|HGNC=32448|UniProtKB=Q6ZQN5 Q6ZQN5 FOXI2 PTHR11829:SF372 FORKHEAD BOX PROTEIN FORKHEAD BOX PROTEIN I2 cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of RNA metabolic process#GO:0051252;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;developmental process#GO:0032502;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=30297|UniProtKB=Q9P258 Q9P258 RCC2 PTHR46207:SF1 PROTEIN RCC2 PROTEIN RCC2 small GTPase binding#GO:0031267;protein binding#GO:0005515;binding#GO:0005488;enzyme binding#GO:0019899 localization#GO:0051179;intracellular protein localization#GO:0008104;regulation of chromosome segregation#GO:0051983;protein localization to organelle#GO:0033365;regulation of cellular process#GO:0050794;regulation of cell cycle#GO:0051726;regulation of cell cycle process#GO:0010564;biological regulation#GO:0065007;positive regulation of cell cycle#GO:0045787;macromolecule localization#GO:0033036;protein localization to kinetochore#GO:0034501;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;positive regulation of cell cycle process#GO:0090068 cellular anatomical structure#GO:0110165;membrane#GO:0016020 HUMAN|HGNC=9664|UniProtKB=P18433 P18433 PTPRA PTHR19134:SF433 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE ALPHA hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725;phosphoprotein phosphatase activity#GO:0004721;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell communication#GO:0007154 protein modifying enzyme#PC00260;protein phosphatase#PC00195 HUMAN|HGNC=655|UniProtKB=P18085 P18085 ARF4 PTHR11711:SF110 ADP RIBOSYLATION FACTOR-RELATED ADP-RIBOSYLATION FACTOR 4 nucleotide binding#GO:0000166;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;guanyl nucleotide binding#GO:0019001;ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265;small molecule binding#GO:0036094;binding#GO:0005488;anion binding#GO:0043168 vesicle-mediated transport#GO:0016192;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule localization#GO:0033036;intracellular protein localization#GO:0008104;protein transport#GO:0015031;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 G-protein#PC00020 Huntington disease#P00029>ARF#P00786 HUMAN|HGNC=17804|UniProtKB=Q9P0Z9 Q9P0Z9 PIPOX PTHR10961:SF46 PEROXISOMAL SARCOSINE OXIDASE PEROXISOMAL SARCOSINE OXIDASE oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 proteinogenic amino acid metabolic process#GO:0170039;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;amino acid metabolic process#GO:0006520;small molecule catabolic process#GO:0044282;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;microbody#GO:0042579;peroxisome#GO:0005777 oxidase#PC00175;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=23787|UniProtKB=Q9P1W3 Q9P1W3 TMEM63C PTHR13018:SF21 PROBABLE MEMBRANE PROTEIN DUF221-RELATED OSMOSENSITIVE CATION CHANNEL TMEM63C gated channel activity#GO:0022836;ligand-gated monoatomic ion channel activity#GO:0015276;channel activity#GO:0015267;calcium-activated cation channel activity#GO:0005227;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion-gated channel activity#GO:0022839;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;ligand-gated monoatomic cation channel activity#GO:0099094;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HUMAN|HGNC=25391|UniProtKB=Q7Z2Y5 Q7Z2Y5 NRK PTHR47096:SF2 MISSHAPEN LIKE KINASE 1 NIK-RELATED PROTEIN KINASE HUMAN|HGNC=20080|UniProtKB=Q70EL2 Q70EL2 USP45 PTHR21646:SF34 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 45 hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;cysteine-type deubiquitinase activity#GO:0004843;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234 macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;DNA damage response#GO:0006974;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;response to stress#GO:0006950;regulation of protein stability#GO:0031647;cellular process#GO:0009987;regulation of biological quality#GO:0065008;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular response to stimulus#GO:0051716 cysteine protease#PC00081 HUMAN|HGNC=2876|UniProtKB=O60610 O60610 DIAPH1 PTHR45691:SF4 PROTEIN DIAPHANOUS PROTEIN DIAPHANOUS HOMOLOG 1 actin filament polymerization#GO:0030041;actin cytoskeleton organization#GO:0030036;protein polymerization#GO:0051258;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;supramolecular fiber organization#GO:0097435;actin filament-based process#GO:0030029;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;cellular process#GO:0009987;actin polymerization or depolymerization#GO:0008154;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;actin filament organization#GO:0007015;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840 intracellular organelle#GO:0043229;actin filament#GO:0005884;cytoskeleton#GO:0005856;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;actin cytoskeleton#GO:0015629;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165 cytoskeletal protein#PC00085 Cytoskeletal regulation by Rho GTPase#P00016>mDia#P00510 HUMAN|HGNC=29683|UniProtKB=Q9H2D1 Q9H2D1 SLC25A32 PTHR45683:SF18 MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED SOLUTE CARRIER FAMILY 25 MEMBER 32 organophosphate ester transmembrane transporter activity#GO:0015605;nucleobase-containing compound transmembrane transporter activity#GO:0015932;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 transport#GO:0006810;cellular process#GO:0009987;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 transporter#PC00227 HUMAN|HGNC=675|UniProtKB=Q13017 Q13017 ARHGAP5 PTHR46005:SF2 RHO GTPASE-ACTIVATING PROTEIN 190 RHO GTPASE-ACTIVATING PROTEIN 5 enzyme activator activity#GO:0008047;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of neuron projection development#GO:0010975;regulation of anatomical structure morphogenesis#GO:0022603;regulation of plasma membrane bounded cell projection organization#GO:0120035;cellular component organization or biogenesis#GO:0071840;regulation of axonogenesis#GO:0050770;regulation of anatomical structure size#GO:0090066;regulation of cell projection organization#GO:0031344;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;regulation of developmental process#GO:0050793;signaling#GO:0023052;cellular component organization#GO:0016043;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular component size#GO:0032535;Rho protein signal transduction#GO:0007266;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of biological quality#GO:0065008;regulation of cell size#GO:0008361 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 GTPase-activating protein#PC00257;G-protein modulator#PC00022 PDGF signaling pathway#P00047>Rho#P01174 HUMAN|HGNC=18519|UniProtKB=Q5JTY5 Q5JTY5 ZNG1C PTHR13748:SF31 COBW-RELATED ZINC-REGULATED GTPASE METALLOPROTEIN ACTIVATOR 1A-RELATED transition metal ion binding#GO:0046914;binding#GO:0005488;small molecule binding#GO:0036094;molecular carrier activity#GO:0140104;ion binding#GO:0043167;cation binding#GO:0043169;metal ion binding#GO:0046872;zinc ion binding#GO:0008270 metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=33273|UniProtKB=P86452 P86452 ZBED6 PTHR47241:SF2 FINGER PROTEIN, PUTATIVE-RELATED ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 6 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=14743|UniProtKB=Q8NH72 Q8NH72 OR4C6 PTHR48002:SF128 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 4C6 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=16233|UniProtKB=Q9H4G1 Q9H4G1 CST9L PTHR46945:SF1 CYSTATIN-9-LIKE CYSTATIN-9-LIKE immune system process#GO:0002376;antimicrobial humoral response#GO:0019730;humoral immune response#GO:0006959;response to external stimulus#GO:0009605;defense response#GO:0006952;defense response to symbiont#GO:0140546;immune response#GO:0006955;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to other organism#GO:0051707;response to stimulus#GO:0050896;defense response to other organism#GO:0098542 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=25445|UniProtKB=Q8N3F9 Q8N3F9 GPR137C PTHR15146:SF1 INTEGRAL MEMBRANE PROTEIN GPR137 INTEGRAL MEMBRANE PROTEIN GPR137C regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;regulation of TORC1 signaling#GO:1903432;regulation of TOR signaling#GO:0032006;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of TORC1 signaling#GO:1904263;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;positive regulation of TOR signaling#GO:0032008;positive regulation of signaling#GO:0023056;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647 membrane#GO:0016020;lysosomal membrane#GO:0005765;vacuole#GO:0005773;cytoplasm#GO:0005737;lytic vacuole#GO:0000323;vacuolar membrane#GO:0005774;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;lytic vacuole membrane#GO:0098852;lysosome#GO:0005764;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=12141|UniProtKB=A0A0B4J280 A0A0B4J280 TRAV40 PTHR19367:SF35 T-CELL RECEPTOR ALPHA CHAIN V REGION T CELL RECEPTOR ALPHA VARIABLE 40 immune response#GO:0006955;immune system process#GO:0002376;adaptive immune response#GO:0002250;response to stimulus#GO:0050896 protein-containing complex#GO:0032991 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=12013|UniProtKB=P67936 P67936 TPM4 PTHR19269:SF70 TROPOMYOSIN TROPOMYOSIN ALPHA-4 CHAIN protein-containing complex binding#GO:0044877;protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;actin filament binding#GO:0051015;actin binding#GO:0003779;binding#GO:0005488 muscle contraction#GO:0006936;actin filament-based process#GO:0030029;cellular component organization or biogenesis#GO:0071840;system process#GO:0003008;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;organelle organization#GO:0006996;cellular component organization#GO:0016043;muscle system process#GO:0003012;cellular process#GO:0009987;actin cytoskeleton organization#GO:0030036;multicellular organismal process#GO:0032501;cytoskeleton organization#GO:0007010 organelle#GO:0043226;supramolecular complex#GO:0099080;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232;actin cytoskeleton#GO:0015629;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;actin filament#GO:0005884 actin binding motor protein#PC00040 HUMAN|HGNC=18010|UniProtKB=Q9NXN4 Q9NXN4 GDAP2 PTHR11106:SF72 GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED GANGLIOSIDE-INDUCED DIFFERENTIATION-ASSOCIATED PROTEIN 2 HUMAN|HGNC=9171|UniProtKB=O00592 O00592 PODXL PTHR12067:SF5 PODOCALYXIN PODOCALYXIN regulation of plasma membrane bounded cell projection organization#GO:0120035;negative regulation of cellular process#GO:0048523;regulation of cell projection organization#GO:0031344;biological regulation#GO:0065007;cell migration#GO:0016477;regulation of cell adhesion#GO:0030155;negative regulation of cell adhesion#GO:0007162;negative regulation of cell-cell adhesion#GO:0022408;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of cell-cell adhesion#GO:0022409;regulation of cell projection assembly#GO:0060491;regulation of cellular component biogenesis#GO:0044087;regulation of cell-cell adhesion#GO:0022407;regulation of cellular process#GO:0050794;cell motility#GO:0048870;regulation of plasma membrane bounded cell projection assembly#GO:0120032;regulation of cellular component organization#GO:0051128;regulation of cell adhesion mediated by integrin#GO:0033628;positive regulation of cell adhesion#GO:0045785;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;plasma membrane region#GO:0098590;apical part of cell#GO:0045177;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;actin-based cell projection#GO:0098858;microvillus#GO:0005902;actin cytoskeleton#GO:0015629;apical plasma membrane#GO:0016324;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cell projection membrane#GO:0031253 cell adhesion molecule#PC00069 HUMAN|HGNC=31104|UniProtKB=Q92614 Q92614 MYO18A PTHR45615:SF13 MYOSIN HEAVY CHAIN, NON-MUSCLE UNCONVENTIONAL MYOSIN-XVIIIA isomerase activity#GO:0016853;cytoskeletal motor activity#GO:0003774;cytoskeletal protein binding#GO:0008092;macromolecular conformation isomerase activity#GO:0120543;microfilament motor activity#GO:0000146;catalytic activity#GO:0003824;protein-containing complex binding#GO:0044877;protein binding#GO:0005515;actin filament binding#GO:0051015;actin binding#GO:0003779;ATP-dependent activity#GO:0140657;binding#GO:0005488;polypeptide conformation or assembly isomerase activity#GO:0120544 cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;cytoskeleton organization#GO:0007010;actomyosin structure organization#GO:0031032;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996 supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;actin cytoskeleton#GO:0015629;myosin complex#GO:0016459 actin or actin-binding cytoskeletal protein#PC00041 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HUMAN|HGNC=1384|UniProtKB=Q9NZU7 Q9NZU7 CABP1 PTHR45917:SF1 CALCIUM-BINDING PROTEIN 1-RELATED CALCIUM-BINDING PROTEIN 1 channel regulator activity#GO:0016247;molecular function regulator activity#GO:0098772;ion channel regulator activity#GO:0099106;calcium channel regulator activity#GO:0005246;transporter regulator activity#GO:0141108 cellular process#GO:0009987;response to radiation#GO:0009314;signal transduction#GO:0007165;detection of stimulus#GO:0051606;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;system process#GO:0003008;response to external stimulus#GO:0009605;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;response to abiotic stimulus#GO:0009628;sensory perception of light stimulus#GO:0050953;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;visual perception#GO:0007601;response to light stimulus#GO:0009416;nervous system process#GO:0050877;sensory perception#GO:0007600;cell communication#GO:0007154 cell periphery#GO:0071944;postsynapse#GO:0098794;membrane#GO:0016020;plasma membrane#GO:0005886;asymmetric synapse#GO:0032279;postsynaptic specialization#GO:0099572;organelle#GO:0043226;neuron to neuron synapse#GO:0098984;synapse#GO:0045202;cellular anatomical structure#GO:0110165;postsynaptic density#GO:0014069;cell junction#GO:0030054 HUMAN|HGNC=25241|UniProtKB=Q8N3R3 Q8N3R3 TCAIM PTHR31596:SF1 T-CELL ACTIVATION INHIBITOR, MITOCHONDRIAL T-CELL ACTIVATION INHIBITOR, MITOCHONDRIAL cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HUMAN|HGNC=28667|UniProtKB=Q9BW04 Q9BW04 SARG PTHR21555:SF0 SPECIFICALLY ANDROGEN-REGULATED GENE PROTEIN SPECIFICALLY ANDROGEN-REGULATED GENE PROTEIN cellular response to steroid hormone stimulus#GO:0071383;biological regulation#GO:0065007;response to lipid#GO:0033993;cellular response to lipid#GO:0071396;nuclear receptor-mediated signaling pathway#GO:0141193;response to chemical#GO:0042221;cellular process#GO:0009987;nuclear receptor-mediated steroid hormone signaling pathway#GO:0030518;signal transduction#GO:0007165;response to hormone#GO:0009725;intracellular signal transduction#GO:0035556;hormone-mediated signaling pathway#GO:0009755;cell communication#GO:0007154;response to steroid hormone#GO:0048545;cellular response to chemical stimulus#GO:0070887;signaling#GO:0023052;intracellular receptor signaling pathway#GO:0030522;cellular response to hormone stimulus#GO:0032870;regulation of cellular process#GO:0050794;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;steroid hormone receptor signaling pathway#GO:0043401;response to endogenous stimulus#GO:0009719 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=9307|UniProtKB=Q06190 Q06190 PPP2R3A PTHR14095:SF3 PHOSPHATASE 2A REGULATORY SUBUNIT-RELATED SERINE_THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B'' SUBUNIT ALPHA enzyme regulator activity#GO:0030234;phosphatase regulator activity#GO:0019208;protein phosphatase regulator activity#GO:0019888;molecular function regulator activity#GO:0098772 regulation of signaling#GO:0023051;embryo development ending in birth or egg hatching#GO:0009792;pattern specification process#GO:0007389;chordate embryonic development#GO:0043009;animal gross anatomical part developmental process#GO:0160108;anatomical structure development#GO:0048856;regulation of cell motility#GO:2000145;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111;muscle structure development#GO:0061061;regulation of cellular process#GO:0050794;regulation of response to stimulus#GO:0048583;regulation of cell migration#GO:0030334;developmental process#GO:0032502;anterior/posterior pattern specification#GO:0009952;anatomical structure formation involved in morphogenesis#GO:0048646;multicellular organism development#GO:0007275;regulation of canonical Wnt signaling pathway#GO:0060828;embryo development#GO:0009790;regulation of locomotion#GO:0040012;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;tissue development#GO:0009888;regionalization#GO:0003002;epithelium development#GO:0060429 protein-containing complex#GO:0032991;protein serine/threonine phosphatase complex#GO:0008287;catalytic complex#GO:1902494 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HUMAN|HGNC=35237|UniProtKB=P0DMP2 P0DMP2 SRGAP2B PTHR14166:SF6 SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 2-RELATED enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047 animal gross anatomical part developmental process#GO:0160108;regulation of synapse organization#GO:0050807;regulation of cell junction assembly#GO:1901888;anatomical structure development#GO:0048856;regulation of synapse structure or activity#GO:0050803;regulation of cell motility#GO:2000145;regulation of biological quality#GO:0065008;system development#GO:0048731;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of cellular component biogenesis#GO:0044087;negative regulation of cellular process#GO:0048523;negative regulation of cell migration#GO:0030336;developmental process#GO:0032502;regulation of cell migration#GO:0030334;multicellular organism development#GO:0007275;multicellular organismal process#GO:0032501;regulation of synapse assembly#GO:0051963;regulation of locomotion#GO:0040012;nervous system development#GO:0007399;biological regulation#GO:0065007;negative regulation of locomotion#GO:0040013;negative regulation of cell motility#GO:2000146 postsynapse#GO:0098794;dendritic spine#GO:0043197;neuron projection#GO:0043005;glutamatergic synapse#GO:0098978;cellular anatomical structure#GO:0110165;synapse#GO:0045202;plasma membrane bounded cell projection#GO:0120025;neuron spine#GO:0044309;cell projection#GO:0042995;somatodendritic compartment#GO:0036477;dendrite#GO:0030425;dendritic tree#GO:0097447;cell junction#GO:0030054 GTPase-activating protein#PC00257;G-protein modulator#PC00022 PDGF signaling pathway#P00047>Rho#P01174 HUMAN|HGNC=21407|UniProtKB=Q53H80 Q53H80 AKIRIN2 PTHR13293:SF8 AKIRIN-RELATED AKIRIN-2 transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 positive regulation of immune response#GO:0050778;positive regulation of defense response#GO:0031349;regulation of response to stimulus#GO:0048583;regulation of response to stress#GO:0080134;positive regulation of response to biotic stimulus#GO:0002833;regulation of gene expression#GO:0010468;regulation of innate immune response#GO:0045088;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;positive regulation of innate immune response#GO:0045089;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;regulation of immune response#GO:0050776;regulation of defense response#GO:0031347;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;positive regulation of RNA metabolic process#GO:0051254;regulation of response to biotic stimulus#GO:0002831;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of response to external stimulus#GO:0032103;positive regulation of biological process#GO:0048518;positive regulation of immune system process#GO:0002684;positive regulation of macromolecule metabolic process#GO:0010604;regulation of response to external stimulus#GO:0032101;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694;chromatin#GO:0000785;nucleus#GO:0005634;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HUMAN|HGNC=19285|UniProtKB=Q8IZE3 Q8IZE3 SCYL3 PTHR12984:SF15 SCY1-RELATED S/T PROTEIN KINASE-LIKE PROTEIN-ASSOCIATING WITH THE CARBOXYL-TERMINAL DOMAIN OF EZRIN non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=3481|UniProtKB=P13804 P13804 ETFA PTHR43153:SF1 ELECTRON TRANSFER FLAVOPROTEIN ALPHA ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT ALPHA, MITOCHONDRIAL anion binding#GO:0043168;flavin adenine dinucleotide binding#GO:0050660;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265;nucleotide binding#GO:0000166;heterocyclic compound binding#GO:1901363 fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;fatty acid beta-oxidation#GO:0006635;lipid metabolic process#GO:0006629;fatty acid oxidation#GO:0019395;lipid modification#GO:0030258;cellular process#GO:0009987;lipid catabolic process#GO:0016042;carboxylic acid catabolic process#GO:0046395;monocarboxylic acid catabolic process#GO:0072329;oxoacid metabolic process#GO:0043436;lipid oxidation#GO:0034440;fatty acid catabolic process#GO:0009062;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;monocarboxylic acid metabolic process#GO:0032787;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;small molecule catabolic process#GO:0044282 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739 oxidoreductase#PC00176 HUMAN|HGNC=17967|UniProtKB=Q9NWZ3 Q9NWZ3 IRAK4 PTHR24419:SF35 INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 4 protein serine/threonine kinase activity#GO:0004674;histone modifying activity#GO:0140993;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;histone kinase activity#GO:0035173;catalytic activity, acting on a protein#GO:0140096 response to biotic stimulus#GO:0009607;cellular response to lipopolysaccharide#GO:0071222;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;response to chemical#GO:0042221;response to cytokine#GO:0034097;cellular response to lipid#GO:0071396;response to lipid#GO:0033993;cell surface receptor signaling pathway#GO:0007166;positive regulation of canonical NF-kappaB signal transduction#GO:0043123;response to lipopolysaccharide#GO:0032496;regulation of biological process#GO:0050789;response to molecule of bacterial origin#GO:0002237;cellular response to cytokine stimulus#GO:0071345;response to stimulus#GO:0050896;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;cellular response to chemical stimulus#GO:0070887;regulation of intracellular signal transduction#GO:1902531;response to oxygen-containing compound#GO:1901700;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;response to peptide#GO:1901652;positive regulation of cellular process#GO:0048522;regulation of canonical NF-kappaB signal transduction#GO:0043122;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;response to other organism#GO:0051707;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;cellular response to molecule of bacterial origin#GO:0071219;response to external stimulus#GO:0009605;positive regulation of signal transduction#GO:0009967;cell cycle#GO:0007049;cellular response to biotic stimulus#GO:0071216;cellular response to stimulus#GO:0051716;mitotic cell cycle#GO:0000278;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;response to external biotic stimulus#GO:0043207;regulation of cell communication#GO:0010646;lipopolysaccharide-mediated signaling pathway#GO:0031663;cytokine-mediated signaling pathway#GO:0019221;response to bacterium#GO:0009617;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 nucleus#GO:0005634;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 Toll receptor signaling pathway#P00054>IRAK4#P01342 HUMAN|HGNC=4022|UniProtKB=Q9Y5J6 Q9Y5J6 TIMM10B PTHR13172:SF0 MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM9B MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10 B molecular carrier activity#GO:0140104;protein carrier activity#GO:0140597 mitochondrial envelope#GO:0005740;membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;mitochondrial intermembrane space#GO:0005758;mitochondrion#GO:0005739;organelle lumen#GO:0043233;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 transporter#PC00227;primary active transporter#PC00068 HUMAN|HGNC=10725|UniProtKB=Q99985 Q99985 SEMA3C PTHR11036:SF25 SEMAPHORIN SEMAPHORIN-3C protein binding#GO:0005515;molecular function activator activity#GO:0140677;signaling receptor binding#GO:0005102;binding#GO:0005488;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545 axonogenesis#GO:0007409;neuron development#GO:0048666;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;signaling#GO:0023052;cell morphogenesis#GO:0000902;response to stimulus#GO:0050896;cell differentiation#GO:0030154;cell projection organization#GO:0030030;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;positive regulation of cell motility#GO:2000147;cell projection morphogenesis#GO:0048858;animal organ development#GO:0048513;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;mesenchymal cell differentiation#GO:0048762;cell surface receptor signaling pathway#GO:0007166;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;neural crest cell differentiation#GO:0014033;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;taxis#GO:0042330;response to chemical#GO:0042221;cellular process#GO:0009987;neural crest cell migration#GO:0001755;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;neuron projection development#GO:0031175;system development#GO:0048731;anatomical structure development#GO:0048856;regulation of cell motility#GO:2000145;cell communication#GO:0007154;chemotaxis#GO:0006935;stem cell development#GO:0048864;locomotion#GO:0040011;regulation of cellular process#GO:0050794;cell motility#GO:0048870;cellular response to stimulus#GO:0051716;mesenchyme development#GO:0060485;neurogenesis#GO:0022008;neuron projection guidance#GO:0097485;response to external stimulus#GO:0009605;positive regulation of locomotion#GO:0040017;cellular developmental process#GO:0048869;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;regulation of cell migration#GO:0030334;regulation of locomotion#GO:0040012;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;cell migration#GO:0016477;tissue development#GO:0009888;neural crest cell development#GO:0014032;multicellular organismal process#GO:0032501;positive regulation of cell migration#GO:0030335;positive regulation of cellular process#GO:0048522;axon development#GO:0061564;axon guidance#GO:0007411;stem cell differentiation#GO:0048863 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;cell periphery#GO:0071944;membrane#GO:0016020 membrane-bound signaling molecule#PC00152 HUMAN|HGNC=925|UniProtKB=O60909 O60909 B4GALT2 PTHR19300:SF32 BETA-1,4-GALACTOSYLTRANSFERASE BETA-1,4-GALACTOSYLTRANSFERASE 2 glycosyltransferase activity#GO:0016757;galactosyltransferase activity#GO:0008378;catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;glycosyltransferase#PC00111 HUMAN|HGNC=28662|UniProtKB=Q9BU89 Q9BU89 DOHH PTHR12697:SF42 PBS LYASE HEAT-LIKE PROTEIN DEOXYHYPUSINE HYDROXYLASE oxidoreductase activity#GO:0016491;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;monooxygenase activity#GO:0004497;catalytic activity#GO:0003824 lyase#PC00144 HUMAN|HGNC=6508|UniProtKB=O43813 O43813 LANCL1 PTHR12736:SF5 LANC-LIKE PROTEIN GLUTATHIONE S-TRANSFERASE LANCL1 transferase activity#GO:0016740;catalytic activity#GO:0003824;glutathione transferase activity#GO:0004364;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765 regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular response to alcohol#GO:1905957;regulation of cellular process#GO:0050794;response to toxic substance#GO:0009636;regulation of cell communication#GO:0010646;cellular response to chemical stimulus#GO:0070887;cellular detoxification#GO:1990748;regulation of abscisic acid-activated signaling pathway#GO:0009787;regulation of signaling#GO:0023051;regulation of response to alcohol#GO:1901419;cellular process#GO:0009987;response to chemical#GO:0042221;regulation of signal transduction#GO:0009966;detoxification#GO:0098754;biological regulation#GO:0065007;cellular response to toxic substance#GO:0097237;regulation of response to stimulus#GO:0048583 HUMAN|HGNC=16702|UniProtKB=Q9BT78 Q9BT78 COPS4 PTHR10855:SF12 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4 COP9 SIGNALOSOME COMPLEX SUBUNIT 4 organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;synaptic vesicle#GO:0008021;COP9 signalosome#GO:0008180;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;transport vesicle#GO:0030133;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasm#GO:0005737;secretory vesicle#GO:0099503;presynapse#GO:0098793;nucleus#GO:0005634;cell junction#GO:0030054;nuclear protein-containing complex#GO:0140513 protease#PC00190 HUMAN|HGNC=25610|UniProtKB=Q96C11 Q96C11 FGGY PTHR43435:SF4 RIBULOKINASE FGGY CARBOHYDRATE KINASE DOMAIN-CONTAINING PROTEIN kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;carbohydrate kinase activity#GO:0019200;transferase activity#GO:0016740;catalytic activity#GO:0003824;phosphotransferase activity, alcohol group as acceptor#GO:0016773 carbohydrate metabolic process#GO:0005975;small molecule metabolic process#GO:0044281;cellular process#GO:0009987;metabolic process#GO:0008152;monosaccharide metabolic process#GO:0005996;primary metabolic process#GO:0044238 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 transferase#PC00220;carbohydrate kinase#PC00065;metabolite interconversion enzyme#PC00262;kinase#PC00137 Ascorbate degradation#P02729>L-xylulose kinase#P02849;Pentose phosphate pathway#P02762>D-Ribulo Kinase#P03077 HUMAN|HGNC=16068|UniProtKB=O95613 O95613 PCNT PTHR44981:SF3 PERICENTRIN-LIKE PROTEIN, ISOFORM F PERICENTRIN mitotic cell cycle#GO:0000278;mitotic spindle organization#GO:0007052;protein-containing complex assembly#GO:0065003;protein polymerization#GO:0051258;cell cycle process#GO:0022402;microtubule nucleation#GO:0007020;cell cycle#GO:0007049;cellular component organization#GO:0016043;microtubule cytoskeleton organization involved in mitosis#GO:1902850;supramolecular fiber organization#GO:0097435;microtubule cytoskeleton organization#GO:0000226;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;microtubule polymerization or depolymerization#GO:0031109;organelle organization#GO:0006996;mitotic cell cycle process#GO:1903047;protein-containing complex organization#GO:0043933;microtubule polymerization#GO:0046785;microtubule-based process#GO:0007017;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840 HUMAN|HGNC=9294|UniProtKB=O95685 O95685 PPP1R3D PTHR12307:SF4 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 3D protein phosphatase binding#GO:0019903;protein binding#GO:0005515;carbohydrate binding#GO:0030246;enzyme binding#GO:0019899;phosphatase binding#GO:0019902;polysaccharide binding#GO:0030247;binding#GO:0005488 regulation of glycogen biosynthetic process#GO:0005979;regulation of carbohydrate metabolic process#GO:0006109;regulation of polysaccharide biosynthetic process#GO:0032885;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of carbohydrate biosynthetic process#GO:0043255;regulation of polysaccharide metabolic process#GO:0032881;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;protein serine/threonine phosphatase complex#GO:0008287 phosphatase modulator#PC00184;protein-binding activity modulator#PC00095 HUMAN|HGNC=25266|UniProtKB=Q8WVZ9 Q8WVZ9 KBTBD7 PTHR24412:SF23 KELCH PROTEIN KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 7 ubiquitin-like ligase-substrate adaptor activity#GO:1990756;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;enzyme-substrate adaptor activity#GO:0140767 catabolic process#GO:0009056;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;regulation of biological process#GO:0050789;protein metabolic process#GO:0019538;regulation of intracellular signal transduction#GO:1902531;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;regulation of signaling#GO:0023051;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;proteasomal protein catabolic process#GO:0010498;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;regulation of small GTPase mediated signal transduction#GO:0051056;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;regulation of response to stimulus#GO:0048583 intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;Cul3-RING ubiquitin ligase complex#GO:0031463;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;transferase complex#GO:1990234;cullin-RING ubiquitin ligase complex#GO:0031461;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=25731|UniProtKB=Q3ZCT8 Q3ZCT8 KBTBD12 PTHR24412:SF510 KELCH PROTEIN KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 12 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;enzyme-substrate adaptor activity#GO:0140767;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498 transferase complex#GO:1990234;catalytic complex#GO:1902494;Cul3-RING ubiquitin ligase complex#GO:0031463;ubiquitin ligase complex#GO:0000151;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cullin-RING ubiquitin ligase complex#GO:0031461;cytoplasm#GO:0005737 scaffold/adaptor protein#PC00226 HUMAN|HGNC=15940|UniProtKB=Q9NTW7 Q9NTW7 ZFP64 PTHR24403:SF114 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 64 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HUMAN|HGNC=23093|UniProtKB=Q8NCK7 Q8NCK7 SLC16A11 PTHR11360:SF80 MONOCARBOXYLATE TRANSPORTER MONOCARBOXYLATE TRANSPORTER 11 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;monocarboxylic acid transmembrane transporter activity#GO:0008028 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227 HUMAN|HGNC=32486|UniProtKB=Q5QGT7 Q5QGT7 RTP2 PTHR14402:SF18 RECEPTOR TRANSPORTING PROTEIN RECEPTOR-TRANSPORTING PROTEIN 2 G protein-coupled receptor binding#GO:0001664;signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515 detection of chemical stimulus involved in sensory perception#GO:0050907;nervous system process#GO:0050877;detection of chemical stimulus involved in sensory perception of taste#GO:0050912;localization within membrane#GO:0051668;sensory perception#GO:0007600;cellular localization#GO:0051641;localization#GO:0051179;cellular component organization#GO:0016043;sensory perception of bitter taste#GO:0050913;detection of chemical stimulus#GO:0009593;protein targeting#GO:0006605;response to stimulus#GO:0050896;sensory perception of chemical stimulus#GO:0007606;protein targeting to membrane#GO:0006612;sensory perception of taste#GO:0050909;detection of chemical stimulus involved in sensory perception of bitter taste#GO:0001580;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;intracellular protein localization#GO:0008104;system process#GO:0003008;macromolecule localization#GO:0033036;establishment of protein localization to membrane#GO:0090150;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;cellular process#GO:0009987;establishment of protein localization#GO:0045184;multicellular organismal process#GO:0032501;protein insertion into membrane#GO:0051205;response to chemical#GO:0042221;membrane organization#GO:0061024 cellular anatomical structure#GO:0110165;cell surface#GO:0009986 membrane traffic protein#PC00150 HUMAN|HGNC=2418|UniProtKB=Q14894 Q14894 CRYM PTHR13812:SF25 KETIMINE REDUCTASE MU-CRYSTALLIN KETIMINE REDUCTASE MU-CRYSTALLIN hormone binding#GO:0042562;binding#GO:0005488 biological regulation#GO:0065007;hormone metabolic process#GO:0042445;phenol-containing compound metabolic process#GO:0018958;cellular process#GO:0009987;regulation of hormone levels#GO:0010817;modified amino acid metabolic process#GO:0006575;regulation of biological quality#GO:0065008;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 reductase#PC00198;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=15453|UniProtKB=Q9H3P7 Q9H3P7 ACBD3 PTHR22973:SF11 LD35087P GOLGI RESIDENT PROTEIN GCP60 protein-membrane adaptor activity#GO:0043495;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;intracellular transport#GO:0046907;transport#GO:0006810;Golgi vesicle transport#GO:0048193;vesicle-mediated transport#GO:0016192;endomembrane system organization#GO:0010256;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;Golgi organization#GO:0007030 membrane#GO:0016020;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588 HUMAN|HGNC=869|UniProtKB=Q04656 Q04656 ATP7A PTHR43520:SF29 ATP7, ISOFORM B COPPER-TRANSPORTING ATPASE 1 primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804;transmembrane transporter activity#GO:0022857;cation binding#GO:0043169;ion binding#GO:0043167;small molecule binding#GO:0036094;transition metal ion binding#GO:0046914;P-type ion transporter activity#GO:0015662;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;copper ion binding#GO:0005507;transporter activity#GO:0005215;metal ion binding#GO:0046872;monoatomic cation transmembrane transporter activity#GO:0008324;transition metal ion transmembrane transporter activity#GO:0046915;binding#GO:0005488;ATPase-coupled transmembrane transporter activity#GO:0042626;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATP-dependent activity#GO:0140657 cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;intracellular monoatomic cation homeostasis#GO:0030003;transport#GO:0006810;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;establishment of localization#GO:0051234;intracellular monoatomic ion homeostasis#GO:0006873;copper ion transmembrane transport#GO:0035434;metal ion transport#GO:0030001;homeostatic process#GO:0042592;inorganic ion homeostasis#GO:0098771;transition metal ion transport#GO:0000041;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;plasma membrane#GO:0005886 primary active transporter#PC00068 HUMAN|HGNC=28429|UniProtKB=Q9H819 Q9H819 DNAJC18 PTHR43908:SF2 AT29763P-RELATED DNAJ HOMOLOG SUBFAMILY C MEMBER 18 protein binding#GO:0005515;Hsp70 protein binding#GO:0030544;binding#GO:0005488;protein-folding chaperone binding#GO:0051087;heat shock protein binding#GO:0031072 macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;cellular response to misfolded protein#GO:0071218;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;response to stress#GO:0006950;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein metabolic process#GO:0019538;cellular response to stress#GO:0033554;cellular response to topologically incorrect protein#GO:0035967;response to stimulus#GO:0050896;response to topologically incorrect protein#GO:0035966;protein folding#GO:0006457;response to misfolded protein#GO:0051788;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827 HUMAN|HGNC=14490|UniProtKB=Q9P0J6 Q9P0J6 MRPL36 PTHR46909:SF3 39S RIBOSOMAL PROTEIN L36, MITOCHONDRIAL LARGE RIBOSOMAL SUBUNIT PROTEIN BL36M intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;organellar ribosome#GO:0000313;mitochondrial ribosome#GO:0005761;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;mitochondrion#GO:0005739;ribosome#GO:0005840;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;membraneless organelle#GO:0043228;mitochondrial large ribosomal subunit#GO:0005762;membrane-enclosed lumen#GO:0031974;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737 ribosomal protein#PC00202 HUMAN|HGNC=13076|UniProtKB=Q9UDV7 Q9UDV7 ZNF282 PTHR23232:SF121 KRAB DOMAIN C2H2 ZINC FINGER ZINC FINGER PROTEIN 282 DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=15495|UniProtKB=Q6PI73 Q6PI73 LILRA6 PTHR11738:SF187 MHC CLASS I NK CELL RECEPTOR LEUKOCYTE IMMUNOGLOBULIN-LIKE RECEPTOR SUBFAMILY A MEMBER 6-RELATED signaling receptor activity#GO:0038023;immune receptor activity#GO:0140375;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 response to cytokine#GO:0034097;response to chemical#GO:0042221;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;signaling#GO:0023052;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;cellular response to stimulus#GO:0051716;immune response-regulating signaling pathway#GO:0002764;cell communication#GO:0007154;response to peptide#GO:1901652;cytokine-mediated signaling pathway#GO:0019221;regulation of immune response#GO:0050776 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=7200|UniProtKB=Q9HCE1 Q9HCE1 MOV10 PTHR10887:SF322 DNA2/NAM7 HELICASE FAMILY RNA HELICASE MOV-10 nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulatory ncRNA-mediated gene silencing#GO:0031047;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulatory ncRNA-mediated post-transcriptional gene silencing#GO:0035194;post-transcriptional gene silencing#GO:0016441 intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;P granule#GO:0043186;cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232 RNA helicase#PC00032 HUMAN|HGNC=23671|UniProtKB=Q7Z4J2 Q7Z4J2 GLT6D1 PTHR10462:SF27 GLYCOSYLTRANSFERASE-RELATED GLYCOSYLTRANSFERASE 6 DOMAIN-CONTAINING PROTEIN 1-RELATED catalytic activity#GO:0003824;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757 vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111 HUMAN|HGNC=9949|UniProtKB=O94761 O94761 RECQL4 PTHR13710:SF167 DNA HELICASE RECQ FAMILY MEMBER ATP-DEPENDENT DNA HELICASE Q4 ATP-dependent activity#GO:0140657;ATP-dependent activity, acting on DNA#GO:0008094;macromolecular conformation isomerase activity#GO:0120543;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;DNA helicase activity#GO:0003678;isomerase activity#GO:0016853;3'-5' DNA helicase activity#GO:0043138;catalytic activity, acting on DNA#GO:0140097;helicase activity#GO:0004386 response to stimulus#GO:0050896;double-strand break repair via homologous recombination#GO:0000724;cellular response to stimulus#GO:0051716;DNA replication#GO:0006260;cellular component organization#GO:0016043;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;telomere organization#GO:0032200;cellular response to stress#GO:0033554;recombinational repair#GO:0000725;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;organelle organization#GO:0006996;response to stress#GO:0006950;double-strand break repair#GO:0006302;telomere maintenance#GO:0000723;chromosome organization#GO:0051276;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;DNA damage response#GO:0006974;DNA recombination#GO:0006310;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259 nucleus#GO:0005634;chromosome#GO:0005694;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228 DNA metabolism protein#PC00009;DNA helicase#PC00011 HUMAN|HGNC=24139|UniProtKB=Q7Z7M8 Q7Z7M8 B3GNT8 PTHR11214:SF87 BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE N-ACETYLLACTOSAMINIDE BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE 8 catalytic activity#GO:0003824;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194 biosynthetic process#GO:0009058;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;aminoglycan biosynthetic process#GO:0006023;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;aminoglycan metabolic process#GO:0006022 membrane#GO:0016020;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111;transferase#PC00220 HUMAN|HGNC=31982|UniProtKB=Q4UJ75 Q4UJ75 ANKRD20A4P PTHR24147:SF1 ANKYRIN REPEAT DOMAIN 36-RELATED ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 20A1-RELATED HUMAN|HGNC=1762|UniProtKB=P22223 P22223 CDH3 PTHR24027:SF446 CADHERIN-23 CADHERIN-3 binding#GO:0005488;cell adhesion molecule binding#GO:0050839;protein binding#GO:0005515;beta-catenin binding#GO:0008013 cell motility#GO:0048870;cell migration#GO:0016477;cell-cell adhesion#GO:0098609;cell adhesion#GO:0007155;cellular process#GO:0009987 cytoplasm#GO:0005737;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane#GO:0016020;membrane protein complex#GO:0098796;intracellular anatomical structure#GO:0005622;extrinsic component of plasma membrane#GO:0019897;extrinsic component of membrane#GO:0019898 cell adhesion molecule#PC00069;cadherin#PC00057 Alzheimer disease-presenilin pathway#P00004>E-cadherin transmembrane fragment#P00139;Wnt signaling pathway#P00057>Cadherin#P01440;Alzheimer disease-presenilin pathway#P00004>E-cadherin#P00118;Alzheimer disease-presenilin pathway#P00004>E-cadherin intracellular fragment#P00168;Alzheimer disease-presenilin pathway#P00004>E-cadherin C-terminal fragment#P00117;Alzheimer disease-presenilin pathway#P00004>E-cadherin N-terminal fragment#P00165;Cadherin signaling pathway#P00012>Cadherin#P00471 HUMAN|HGNC=3338|UniProtKB=Q14247 Q14247 CTTN PTHR10829:SF15 CORTACTIN AND DREBRIN SRC SUBSTRATE CORTACTIN binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;actin filament binding#GO:0051015;protein binding#GO:0005515;protein-containing complex binding#GO:0044877 cell-substrate adhesion#GO:0031589;anatomical structure development#GO:0048856;system development#GO:0048731;synapse organization#GO:0050808;regulation of cytoskeleton organization#GO:0051493;regulation of protein polymerization#GO:0032271;regulation of cellular process#GO:0050794;cell motility#GO:0048870;cell junction organization#GO:0034330;cell-substrate junction assembly#GO:0007044;regulation of supramolecular fiber organization#GO:1902903;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;regulation of actin filament-based process#GO:0032970;developmental process#GO:0032502;cell-substrate junction organization#GO:0150115;neuron projection morphogenesis#GO:0048812;focal adhesion assembly#GO:0048041;regulation of actin filament polymerization#GO:0030833;cell migration#GO:0016477;multicellular organismal process#GO:0032501;regulation of actin polymerization or depolymerization#GO:0008064;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;regulation of actin filament organization#GO:0110053;neuron development#GO:0048666;regulation of biological quality#GO:0065008;animal gross anatomical part developmental process#GO:0160108;cell-matrix adhesion#GO:0007160;generation of neurons#GO:0048699;regulation of actin filament length#GO:0030832;cell adhesion#GO:0007155;regulation of cellular component organization#GO:0051128;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell morphogenesis#GO:0000902;regulation of cellular component biogenesis#GO:0044087;cell development#GO:0048468;cell junction assembly#GO:0034329;cellular component organization#GO:0016043;regulation of protein-containing complex assembly#GO:0043254;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;regulation of cellular component size#GO:0032535;regulation of organelle organization#GO:0033043;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cell projection morphogenesis#GO:0048858;regulation of anatomical structure size#GO:0090066;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;cellular component assembly#GO:0022607;regulation of actin cytoskeleton organization#GO:0032956;nervous system development#GO:0007399;neuron projection development#GO:0031175;cellular component biogenesis#GO:0044085;cellular process#GO:0009987 actin cytoskeleton#GO:0015629;cortical cytoskeleton#GO:0030863;cell cortex#GO:0005938;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;site of polarized growth#GO:0030427;cell leading edge#GO:0031252;membrane#GO:0016020;cell periphery#GO:0071944;lamellipodium#GO:0030027;supramolecular complex#GO:0099080;glutamatergic synapse#GO:0098978;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;cytoplasm#GO:0005737;cortical actin cytoskeleton#GO:0030864;cytoskeleton#GO:0005856;actin filament#GO:0005884;cell junction#GO:0030054;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228 non-motor actin binding protein#PC00165;cytoskeletal protein#PC00085 HUMAN|HGNC=1631|UniProtKB=Q86VB7 Q86VB7 CD163 PTHR19331:SF441 SCAVENGER RECEPTOR DOMAIN-CONTAINING SCAVENGER RECEPTOR CYSTEINE-RICH TYPE 1 PROTEIN M130 cargo receptor activity#GO:0038024 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 serine protease#PC00203;protease#PC00190 HUMAN|HGNC=33879|UniProtKB=Q5SXM8 Q5SXM8 DNLZ PTHR20922:SF13 DNL-TYPE ZINC FINGER PROTEIN DNL-TYPE ZINC FINGER PROTEIN cellular localization#GO:0051641;transmembrane transport#GO:0055085;protein transport#GO:0015031;mitochondrial transmembrane transport#GO:1990542;mitochondrial transport#GO:0006839;protein folding#GO:0006457;cellular component organization#GO:0016043;protein localization to mitochondrion#GO:0070585;protein-containing complex assembly#GO:0065003;intracellular protein transmembrane transport#GO:0065002;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;metabolic process#GO:0008152;protein transmembrane transport#GO:0071806;intracellular protein transport#GO:0006886;protein maturation#GO:0051604;gene expression#GO:0010467;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;protein metabolic process#GO:0019538;localization#GO:0051179;chaperone-mediated protein complex assembly#GO:0051131;protein localization to organelle#GO:0033365;primary metabolic process#GO:0044238;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;establishment of protein localization to organelle#GO:0072594;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;transport#GO:0006810;protein transmembrane import into intracellular organelle#GO:0044743;protein import into mitochondrial matrix#GO:0030150;mitochondrial protein import pathway#GO:7770058;biosynthetic process#GO:0009058;macromolecule localization#GO:0033036;macromolecule biosynthetic process#GO:0009059 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=11514|UniProtKB=O43581 O43581 SYT7 PTHR10024:SF385 SYNAPTOTAGMIN SYNAPTOTAGMIN-7 SNARE binding#GO:0000149;binding#GO:0005488;phospholipid binding#GO:0005543;molecular function regulator activity#GO:0098772;lipid binding#GO:0008289;molecular sensor activity#GO:0140299;protein binding#GO:0005515 vesicle fusion#GO:0006906;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;chemical synaptic transmission#GO:0007268;signal release from synapse#GO:0099643;regulation of exocytosis#GO:0017157;cell communication#GO:0007154;regulation of secretion#GO:0051046;localization#GO:0051179;secretion#GO:0046903;signal release#GO:0023061;trans-synaptic signaling#GO:0099537;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;membrane organization#GO:0061024;neurotransmitter secretion#GO:0007269;positive regulation of cellular process#GO:0048522;membrane fusion#GO:0061025;establishment of localization#GO:0051234;synaptic vesicle cycle#GO:0099504;transport#GO:0006810;export from cell#GO:0140352;signaling#GO:0023052;regulation of cellular component organization#GO:0051128;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;cellular component organization#GO:0016043;secretion by cell#GO:0032940;regulation of secretion by cell#GO:1903530;cellular localization#GO:0051641;positive regulation of organelle organization#GO:0010638;positive regulation of cellular component organization#GO:0051130;neurotransmitter transport#GO:0006836;organelle membrane fusion#GO:0090174;organelle fusion#GO:0048284;vesicle-mediated transport#GO:0016192;synaptic vesicle exocytosis#GO:0016079;positive regulation of biological process#GO:0048518;positive regulation of transport#GO:0051050;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle organization#GO:0006996;synaptic signaling#GO:0099536;regulation of transport#GO:0051049;regulation of localization#GO:0032879;positive regulation of vesicle fusion#GO:0031340;exocytosis#GO:0006887;vesicle organization#GO:0016050;cellular component organization or biogenesis#GO:0071840;vesicle-mediated transport in synapse#GO:0099003;regulated exocytosis#GO:0045055 cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;axon#GO:0030424;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;cell projection#GO:0042995;intracellular vesicle#GO:0097708;synaptic vesicle#GO:0008021;vesicle#GO:0031982;cell junction#GO:0030054;endomembrane system#GO:0012505;transport vesicle#GO:0030133;cytoplasm#GO:0005737;plasma membrane#GO:0005886;secretory vesicle#GO:0099503;membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005;presynapse#GO:0098793 membrane trafficking regulatory protein#PC00151 Synaptic vesicle trafficking#P05734>Synaptotagmin#P05769 HUMAN|HGNC=24096|UniProtKB=Q8IVW1 Q8IVW1 ARL17A PTHR11711:SF347 ADP RIBOSYLATION FACTOR-RELATED ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 17 C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;guanyl nucleotide binding#GO:0019001;nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;anion binding#GO:0043168;nucleotide binding#GO:0000166;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639 macromolecule localization#GO:0033036;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;protein transport#GO:0015031 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 G-protein#PC00020 HUMAN|HGNC=27937|UniProtKB=Q6ZVH7 Q6ZVH7 ESPNL PTHR24153:SF0 ESPIN ESPIN-LIKE PROTEIN protein-containing complex binding#GO:0044877;protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;actin filament binding#GO:0051015;actin binding#GO:0003779;binding#GO:0005488 system process#GO:0003008;actin filament organization#GO:0007015;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;multicellular organismal process#GO:0032501;sensory perception of mechanical stimulus#GO:0050954;sensory perception#GO:0007600;nervous system process#GO:0050877;actin filament-based process#GO:0030029;supramolecular fiber organization#GO:0097435;actin filament bundle assembly#GO:0051017;actin filament bundle organization#GO:0061572;cellular component organization#GO:0016043;sensory perception of sound#GO:0007605;actin cytoskeleton organization#GO:0030036 actin cytoskeleton#GO:0015629;neuron projection#GO:0043005;actin-based cell projection#GO:0098858;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;plasma membrane bounded cell projection#GO:0120025;stereocilium#GO:0032420;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;cluster of actin-based cell projections#GO:0098862;intracellular anatomical structure#GO:0005622 non-motor actin binding protein#PC00165;actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=16864|UniProtKB=Q15398 Q15398 DLGAP5 PTHR12353:SF1 DISKS LARGE-ASSOCIATED PROTEIN DAP SAP90/PSD-95-ASSOCIATED PROTEIN DISKS LARGE-ASSOCIATED PROTEIN 5 microtubule binding#GO:0008017;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;protein binding#GO:0005515 cellular component assembly#GO:0022607;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;regulation of mitotic cell cycle#GO:0007346;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;spindle organization#GO:0007051;mitotic cell cycle process#GO:1903047;protein-containing complex organization#GO:0043933;chromosome organization#GO:0051276;microtubule-based process#GO:0007017;chromosome segregation#GO:0007059;mitotic cell cycle#GO:0000278;mitotic spindle organization#GO:0007052;regulation of cellular process#GO:0050794;regulation of cell cycle#GO:0051726;centrosome localization#GO:0051642;cell cycle#GO:0007049;membraneless organelle assembly#GO:0140694;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;regulation of biological process#GO:0050789;cell cycle process#GO:0022402;localization#GO:0051179;kinetochore organization#GO:0051383;microtubule cytoskeleton organization#GO:0000226;organelle assembly#GO:0070925;kinetochore assembly#GO:0051382 membraneless organelle#GO:0043228;spindle#GO:0005819;microtubule organizing center#GO:0005815;centrosome#GO:0005813;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;nucleus#GO:0005634;microtubule cytoskeleton#GO:0015630;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;spindle pole#GO:0000922 scaffold/adaptor protein#PC00226 HUMAN|HGNC=28135|UniProtKB=Q9BT92 Q9BT92 TCHP PTHR31183:SF2 TRICHOPLEIN KERATIN FILAMENT-BINDING PROTEIN FAMILY MEMBER TRICHOPLEIN KERATIN FILAMENT-BINDING PROTEIN programmed cell death#GO:0012501;cellular process#GO:0009987;cell death#GO:0008219;apoptotic process#GO:0006915 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;intermediate filament#GO:0005882;supramolecular fiber#GO:0099512;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;organelle#GO:0043226;supramolecular complex#GO:0099080 structural protein#PC00211 HUMAN|HGNC=14792|UniProtKB=P0C7T3 P0C7T3 OR56A5 PTHR26450:SF454 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 56A5 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=7530|UniProtKB=Q03426 Q03426 MVK PTHR43290:SF4 MEVALONATE KINASE MEVALONATE KINASE transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773 biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;lipid biosynthetic process#GO:0008610;organophosphate metabolic process#GO:0019637;acyl-CoA metabolic process#GO:0006637;secondary alcohol biosynthetic process#GO:1902653;sterol metabolic process#GO:0016125;steroid biosynthetic process#GO:0006694;small molecule biosynthetic process#GO:0044283;cholesterol metabolic process#GO:0008203;lipid metabolic process#GO:0006629;phospholipid metabolic process#GO:0006644;nucleoside phosphate metabolic process#GO:0006753;phospholipid biosynthetic process#GO:0008654;primary metabolic process#GO:0044238;organophosphate biosynthetic process#GO:0090407;isoprenoid metabolic process#GO:0006720;acetyl-CoA metabolic process#GO:0006084;sterol biosynthetic process#GO:0016126;steroid metabolic process#GO:0008202;cholesterol biosynthetic process#GO:0006695;alcohol biosynthetic process#GO:0046165;cellular process#GO:0009987;sulfur compound metabolic process#GO:0006790;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;alcohol metabolic process#GO:0006066;secondary alcohol metabolic process#GO:1902652;small molecule metabolic process#GO:0044281;purine-containing compound metabolic process#GO:0072521;phosphorus metabolic process#GO:0006793;isoprenoid biosynthetic process#GO:0008299 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 carbohydrate kinase#PC00065 Cholesterol biosynthesis#P00014>Mevalonate kinase#P00492 HUMAN|HGNC=27006|UniProtKB=Q5TF58 Q5TF58 IFFO2 PTHR14516:SF1 1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE FAMILY MEMBER INTERMEDIATE FILAMENT FAMILY ORPHAN 2 oxidoreductase#PC00176;dehydrogenase#PC00092 HUMAN|HGNC=24723|UniProtKB=Q9H6R3 Q9H6R3 ACSS3 PTHR43347:SF5 ACYL-COA SYNTHETASE ACYL-COA SYNTHETASE SHORT-CHAIN FAMILY MEMBER 3, MITOCHONDRIAL ligase activity#GO:0016874;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;ligase activity, forming carbon-sulfur bonds#GO:0016877 intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;ligase#PC00142 Acetate utilization#P02722>Acetyl-CoA synthetase#P02803 HUMAN|HGNC=32929|UniProtKB=Q6UWQ7 Q6UWQ7 IGFL2 PTHR34827:SF7 INSULIN GROWTH FACTOR-LIKE FAMILY MEMBER 3-RELATED INSULIN GROWTH FACTOR-LIKE FAMILY MEMBER 2 protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 growth factor#PC00112;intercellular signal molecule#PC00207 HUMAN|HGNC=2470|UniProtKB=Q16527 Q16527 CSRP2 PTHR24215:SF3 RHO-GTPASE-ACTIVATING PROTEIN LRG1 CYSTEINE AND GLYCINE-RICH PROTEIN 2 structural molecule activity#GO:0005198;protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;binding#GO:0005488 striated muscle cell development#GO:0055002;animal gross anatomical part developmental process#GO:0160108;cell differentiation#GO:0030154;cell development#GO:0048468;actomyosin structure organization#GO:0031032;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cellular component organization or biogenesis#GO:0071840;striated muscle cell differentiation#GO:0051146;anatomical structure formation involved in morphogenesis#GO:0048646;cellular anatomical entity morphogenesis#GO:0032989;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;anatomical structure development#GO:0048856;muscle tissue development#GO:0060537;supramolecular fiber organization#GO:0097435;cellular component assembly involved in morphogenesis#GO:0010927;organelle assembly#GO:0070925;actin filament-based process#GO:0030029;sarcomere organization#GO:0045214;actin cytoskeleton organization#GO:0030036;muscle structure development#GO:0061061;muscle cell development#GO:0055001;myofibril assembly#GO:0030239;muscle cell differentiation#GO:0042692;cellular developmental process#GO:0048869;developmental process#GO:0032502;tissue development#GO:0009888 Z disc#GO:0030018;nucleus#GO:0005634;contractile muscle fiber#GO:0043292;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;I band#GO:0031674;membraneless organelle#GO:0043228;sarcomere#GO:0030017;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;myofibril#GO:0030016;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;supramolecular fiber#GO:0099512 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=9460|UniProtKB=P22891 P22891 PROZ PTHR24278:SF20 COAGULATION FACTOR VITAMIN K-DEPENDENT PROTEIN Z serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;serine-type peptidase activity#GO:0008236;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;catalytic activity#GO:0003824 wound healing#GO:0042060;regulation of biological quality#GO:0065008;blood coagulation#GO:0007596;coagulation#GO:0050817;hemostasis#GO:0007599;response to stress#GO:0006950;response to wounding#GO:0009611;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regulation of body fluid levels#GO:0050878;response to stimulus#GO:0050896 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 serine protease#PC00203 Blood coagulation#P00011>PZ#P00407 HUMAN|HGNC=1987|UniProtKB=Q99967 Q99967 CITED2 PTHR17045:SF7 MELANOCYTE SPECIFIC GENE RELATED CITED CBP_P300-INTERACTING TRANSACTIVATOR 2 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription coactivator activity#GO:0003713 cellular response to stimulus#GO:0051716;cellular response to transforming growth factor beta stimulus#GO:0071560;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;response to growth factor#GO:0070848;response to transforming growth factor beta#GO:0071559;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of biosynthetic process#GO:0009891;cell communication#GO:0007154;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;signaling#GO:0023052;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;cellular response to growth factor stimulus#GO:0071363;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;response to hormone#GO:0009725;transforming growth factor beta receptor signaling pathway#GO:0007179;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;response to chemical#GO:0042221;positive regulation of macromolecule metabolic process#GO:0010604;cell surface receptor signaling pathway#GO:0007166 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 TGF-beta signaling pathway#P00052>Co-activators corepressors#P01282 HUMAN|HGNC=24133|UniProtKB=Q9ULZ2 Q9ULZ2 STAP1 PTHR16186:SF10 SIGNAL-TRANSDUCING ADAPTOR PROTEIN-RELATED SIGNAL-TRANSDUCING ADAPTOR PROTEIN 1 molecular adaptor activity#GO:0060090;signaling adaptor activity#GO:0035591;protein binding#GO:0005515;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;binding#GO:0005488;kinase binding#GO:0019900;protein-macromolecule adaptor activity#GO:0030674 positive regulation of immune response#GO:0050778;cell surface receptor signaling pathway#GO:0007166;regulation of response to stimulus#GO:0048583;positive regulation of response to stimulus#GO:0048584;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of immune system process#GO:0002684;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of signaling#GO:0023056;regulation of immune response#GO:0050776;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of signaling#GO:0023051;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of immune system process#GO:0002682;signaling#GO:0023052;regulation of B cell receptor signaling pathway#GO:0050855;regulation of cell communication#GO:0010646;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716 scaffold/adaptor protein#PC00226 HUMAN|HGNC=563|UniProtKB=P63010 P63010 AP2B1 PTHR11134:SF9 ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER AP-2 COMPLEX SUBUNIT BETA binding#GO:0005488;clathrin binding#GO:0030276;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;protein binding#GO:0005515 clathrin-dependent endocytosis#GO:0072583;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;endocytosis#GO:0006897;transport#GO:0006810;receptor-mediated endocytosis#GO:0006898;localization#GO:0051179;establishment of localization#GO:0051234;import into cell#GO:0098657 organelle#GO:0043226;clathrin coat#GO:0030118;cellular anatomical structure#GO:0110165;Golgi-associated vesicle membrane#GO:0030660;coated vesicle membrane#GO:0030662;intracellular vesicle#GO:0097708;clathrin-coated pit#GO:0005905;coated membrane#GO:0048475;endocytic vesicle#GO:0030139;coated vesicle#GO:0030135;intracellular organelle#GO:0043229;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;vesicle coat#GO:0030120;cytoplasm#GO:0005737;clathrin-coated vesicle membrane#GO:0030665;clathrin-coated endocytic vesicle#GO:0045334;AP-type membrane coat adaptor complex#GO:0030119;bounding membrane of organelle#GO:0098588;clathrin vesicle coat#GO:0030125;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;vesicle#GO:0031982;plasma membrane protein complex#GO:0098797;membrane coat#GO:0030117;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;trans-Golgi network transport vesicle#GO:0030140;AP-1 adaptor complex#GO:0030121;transport vesicle#GO:0030133;transport vesicle membrane#GO:0030658;endomembrane system#GO:0012505;plasma membrane#GO:0005886;vesicle membrane#GO:0012506;membrane#GO:0016020;cell periphery#GO:0071944;organelle membrane#GO:0031090;Golgi-associated vesicle#GO:0005798;Golgi apparatus#GO:0005794;trans-Golgi network transport vesicle membrane#GO:0012510;clathrin-coated vesicle#GO:0030136 membrane traffic protein#PC00150 HUMAN|HGNC=9526|UniProtKB=Q00887 Q00887 PSG9 PTHR44427:SF13 CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 19 PREGNANCY-SPECIFIC BETA-1-GLYCOPROTEIN 4-RELATED cell adhesion molecule#PC00069 HUMAN|HGNC=15503|UniProtKB=P59901 P59901 LILRA4 PTHR11738:SF98 MHC CLASS I NK CELL RECEPTOR LEUKOCYTE IMMUNOGLOBULIN-LIKE RECEPTOR SUBFAMILY A MEMBER 4 transmembrane signaling receptor activity#GO:0004888;immune receptor activity#GO:0140375;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 response to peptide#GO:1901652;cell communication#GO:0007154;regulation of immune response#GO:0050776;cytokine-mediated signaling pathway#GO:0019221;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;cellular response to stimulus#GO:0051716;immune response-regulating signaling pathway#GO:0002764;regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;response to chemical#GO:0042221;response to cytokine#GO:0034097;signal transduction#GO:0007165;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=4329|UniProtKB=P48167 P48167 GLRB PTHR18945:SF29 NEUROTRANSMITTER GATED ION CHANNEL GLYCINE RECEPTOR SUBUNIT BETA channel activity#GO:0015267;monoatomic anion channel activity#GO:0005253;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;monoatomic anion transmembrane transporter activity#GO:0008509;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;chloride transmembrane transporter activity#GO:0015108;chloride channel activity#GO:0005254 monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698;transmembrane transport#GO:0055085;chloride transmembrane transport#GO:1902476;localization#GO:0051179;cell communication#GO:0007154;trans-synaptic signaling#GO:0099537;signaling#GO:0023052;anterograde trans-synaptic signaling#GO:0098916;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;monoatomic anion transport#GO:0006820;establishment of localization#GO:0051234;transport#GO:0006810;chloride transport#GO:0006821;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;monoatomic anion transmembrane transport#GO:0098656;cellular process#GO:0009987;synaptic signaling#GO:0099536 synaptic membrane#GO:0097060;postsynaptic specialization membrane#GO:0099634;postsynaptic membrane#GO:0045211;cell junction#GO:0030054;cell periphery#GO:0071944;membrane#GO:0016020;postsynapse#GO:0098794;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590 ligand-gated ion channel#PC00141 HUMAN|HGNC=1314|UniProtKB=Q6ICG6 Q6ICG6 KIAA0930 PTHR21477:SF13 ZGC:172139 KIAA0930 HUMAN|HGNC=24540|UniProtKB=Q9BS18 Q9BS18 ANAPC13 PTHR28672:SF1 ANAPHASE-PROMOTING COMPLEX SUBUNIT 13 ANAPHASE-PROMOTING COMPLEX SUBUNIT 13 macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;cellular process#GO:0009987;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;protein modification process#GO:0036211;primary metabolic process#GO:0044238;protein K11-linked ubiquitination#GO:0070979 transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;nucleus#GO:0005634;protein-containing complex#GO:0032991;anaphase-promoting complex#GO:0005680;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ubiquitin ligase complex#GO:0000151;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;nuclear ubiquitin ligase complex#GO:0000152;cellular anatomical structure#GO:0110165;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=6855|UniProtKB=Q99759 Q99759 MAP3K3 PTHR24361:SF656 MITOGEN-ACTIVATED KINASE KINASE KINASE MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3 phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 MAPK cascade#GO:0000165;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;intracellular signaling cassette#GO:0141124;signaling#GO:0023052;biological regulation#GO:0065007 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 Gonadotropin-releasing hormone receptor pathway#P06664>MAP3Ks#P06834;FGF signaling pathway#P00021>MEKK1-5#P00634;B cell activation#P00010>MEKK#P00369;EGF receptor signaling pathway#P00018>MEKK1-5#P00553;Integrin signalling pathway#P00034>ERK#P00907 HUMAN|HGNC=25325|UniProtKB=Q6ZU64 Q6ZU64 CFAP65 PTHR46127:SF2 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 65 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 65 cellular process#GO:0009987;cell projection assembly#GO:0030031;cilium movement involved in cell motility#GO:0060294;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;motile cilium assembly#GO:0044458;sperm motility#GO:0097722;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cellular process involved in reproduction in multicellular organism#GO:0022412;cell development#GO:0048468;gamete generation#GO:0007276;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;spermatid differentiation#GO:0048515;cilium organization#GO:0044782;cilium-dependent cell motility#GO:0060285;sperm flagellum assembly#GO:0120316;plasma membrane bounded cell projection organization#GO:0120036;male gamete generation#GO:0048232;spermatogenesis#GO:0007283;developmental process#GO:0032502;plasma membrane bounded cell projection assembly#GO:0120031;flagellated sperm motility#GO:0030317;sperm axoneme assembly#GO:0007288;cellular developmental process#GO:0048869;germ cell development#GO:0007281;developmental process involved in reproduction#GO:0003006;reproductive process#GO:0022414;microtubule-based movement#GO:0007018;cell motility#GO:0048870;microtubule bundle formation#GO:0001578;spermatid development#GO:0007286;sexual reproduction#GO:0019953;organelle assembly#GO:0070925;multicellular organismal reproductive process#GO:0048609;axoneme assembly#GO:0035082;anatomical structure development#GO:0048856;microtubule cytoskeleton organization#GO:0000226 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cilium#GO:0005929;9+2 motile cilium#GO:0097729;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;sperm flagellum#GO:0036126;motile cilium#GO:0031514;organelle#GO:0043226 structural protein#PC00211 HUMAN|HGNC=11610|UniProtKB=O15273 O15273 TCAP PTHR15143:SF0 TELETHONIN TELETHONIN structural molecule activity#GO:0005198;protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;binding#GO:0005488 cardiac muscle tissue development#GO:0048738;cellular developmental process#GO:0048869;response to external stimulus#GO:0009605;system process#GO:0003008;heart contraction#GO:0060047;detection of mechanical stimulus#GO:0050982;muscle contraction#GO:0006936;developmental process#GO:0032502;blood circulation#GO:0008015;tissue development#GO:0009888;detection of stimulus#GO:0051606;tissue morphogenesis#GO:0048729;muscle tissue development#GO:0060537;supramolecular fiber organization#GO:0097435;system development#GO:0048731;organelle assembly#GO:0070925;circulatory system process#GO:0003013;cardiac muscle contraction#GO:0060048;actin cytoskeleton organization#GO:0030036;heart morphogenesis#GO:0003007;myofibril assembly#GO:0030239;animal organ development#GO:0048513;heart development#GO:0007507;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;cell differentiation#GO:0030154;circulatory system development#GO:0072359;actomyosin structure organization#GO:0031032;skeletal muscle contraction#GO:0003009;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;muscle system process#GO:0003012;heart process#GO:0003015;actin filament organization#GO:0007015;multicellular organismal process#GO:0032501;response to mechanical stimulus#GO:0009612;anatomical structure development#GO:0048856;cellular component assembly involved in morphogenesis#GO:0010927;neuromuscular process#GO:0050905;actin filament-based process#GO:0030029;muscle structure development#GO:0061061;animal organ morphogenesis#GO:0009887;striated muscle contraction#GO:0006941;muscle cell development#GO:0055001;muscle cell differentiation#GO:0042692;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;anatomical structure formation involved in morphogenesis#GO:0048646;striated muscle cell differentiation#GO:0051146;muscle organ development#GO:0007517;cellular anatomical entity morphogenesis#GO:0032989;striated muscle tissue development#GO:0014706;cardiac muscle cell differentiation#GO:0055007;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;striated muscle cell development#GO:0055002;animal gross anatomical part developmental process#GO:0160108;nervous system process#GO:0050877;response to stimulus#GO:0050896;cell development#GO:0048468;response to abiotic stimulus#GO:0009628;protein-containing complex assembly#GO:0065003;anatomical structure morphogenesis#GO:0009653 intracellular organelle#GO:0043229;I band#GO:0031674;membraneless organelle#GO:0043228;myofibril#GO:0030016;sarcomere#GO:0030017;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;Z disc#GO:0030018;contractile muscle fiber#GO:0043292;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;organelle#GO:0043226;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232 HUMAN|HGNC=32395|UniProtKB=Q5KSL6 Q5KSL6 DGKK PTHR11255:SF33 DIACYLGLYCEROL KINASE DIACYLGLYCEROL KINASE KAPPA lipid kinase activity#GO:0001727;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 neutral lipid metabolic process#GO:0006638;acylglycerol metabolic process#GO:0006639;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474;lipid biosynthetic process#GO:0008610;glycerophospholipid metabolic process#GO:0006650;biological regulation#GO:0065007;biosynthetic process#GO:0009058;organophosphate metabolic process#GO:0019637;glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987;signal transduction#GO:0007165;organophosphate biosynthetic process#GO:0090407;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;phospholipid biosynthetic process#GO:0008654;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;glycerolipid metabolic process#GO:0046486;phospholipid metabolic process#GO:0006644;signaling#GO:0023052;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 kinase#PC00137;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=7063|UniProtKB=Q99735 Q99735 MGST2 PTHR10250:SF13 MICROSOMAL GLUTATHIONE S-TRANSFERASE MICROSOMAL GLUTATHIONE S-TRANSFERASE 2 lyase activity#GO:0016829;carbon-sulfur lyase activity#GO:0016846;oxidoreductase activity, acting on peroxide as acceptor#GO:0016684;glutathione transferase activity#GO:0004364;oxidoreductase activity#GO:0016491;peroxidase activity#GO:0004601;antioxidant activity#GO:0016209;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765 small molecule metabolic process#GO:0044281;icosanoid metabolic process#GO:0006690;icosanoid biosynthetic process#GO:0046456;biosynthetic process#GO:0009058;carboxylic acid metabolic process#GO:0019752;cellular process#GO:0009987;carboxylic acid biosynthetic process#GO:0046394;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;small molecule biosynthetic process#GO:0044283 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nuclear envelope#GO:0005635;organelle envelope#GO:0031967;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 transferase#PC00220 HUMAN|HGNC=12788|UniProtKB=Q9H1J5 Q9H1J5 WNT8A PTHR12027:SF92 WNT RELATED PROTEIN WNT-8A receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;frizzled binding#GO:0005109;G protein-coupled receptor binding#GO:0001664;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;binding#GO:0005488;signaling receptor binding#GO:0005102;cytokine activity#GO:0005125;protein binding#GO:0005515;molecular function activator activity#GO:0140677 signal transduction#GO:0007165;cellular process#GO:0009987;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;nervous system development#GO:0007399;developmental process#GO:0032502;neuron differentiation#GO:0030182;cell surface receptor signaling pathway#GO:0007166;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell differentiation#GO:0030154;response to stimulus#GO:0050896;Wnt signaling pathway#GO:0016055;regulation of cellular process#GO:0050794;signaling#GO:0023052;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;canonical Wnt signaling pathway#GO:0060070;cell communication#GO:0007154;anatomical structure development#GO:0048856;cell fate commitment#GO:0045165;system development#GO:0048731 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 Wnt signaling pathway#P00057>Wnt#P01444;Alzheimer disease-presenilin pathway#P00004>Wnt#P00142;Cadherin signaling pathway#P00012>Wnt#P00474 HUMAN|HGNC=6484|UniProtKB=Q16363 Q16363 LAMA4 PTHR15036:SF47 PIKACHURIN-LIKE PROTEIN LAMININ SUBUNIT ALPHA-4 multicellular organism development#GO:0007275;developmental process#GO:0032502;nervous system development#GO:0007399;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;cellular process#GO:0009987;signal transduction#GO:0007165;system development#GO:0048731;anatomical structure development#GO:0048856;cell communication#GO:0007154;animal gross anatomical part developmental process#GO:0160108;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789 extracellular region#GO:0005576;cell junction#GO:0030054;extracellular matrix#GO:0031012;membrane#GO:0016020;external encapsulating structure#GO:0030312;cell periphery#GO:0071944;basement membrane#GO:0005604;synapse#GO:0045202;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cell adhesion molecule#PC00069 Integrin signalling pathway#P00034>Laminin#P00947 HUMAN|HGNC=11825|UniProtKB=P43699 P43699 NKX2-1 PTHR24340:SF33 HOMEOBOX PROTEIN NKX HOMEOBOX PROTEIN NKX-2.1 DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;developmental process#GO:0032502 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=31978|UniProtKB=Q4V339 Q4V339 ZNG1F PTHR13748:SF31 COBW-RELATED ZINC-REGULATED GTPASE METALLOPROTEIN ACTIVATOR 1A-RELATED metal ion binding#GO:0046872;cation binding#GO:0043169;molecular carrier activity#GO:0140104;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;transition metal ion binding#GO:0046914;zinc ion binding#GO:0008270 protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=12394|UniProtKB=O95801 O95801 TTC4 PTHR46035:SF4 TETRATRICOPEPTIDE REPEAT PROTEIN 4 HSP70_HSP90 CO-CHAPERONE CNS1 HOMOLOG Hsp70 protein binding#GO:0030544;protein binding#GO:0005515;heat shock protein binding#GO:0031072;Hsp90 protein binding#GO:0051879;protein-folding chaperone binding#GO:0051087;binding#GO:0005488 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;biosynthetic process#GO:0009058;protein folding#GO:0006457;gene expression#GO:0010467;protein maturation#GO:0051604;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=24325|UniProtKB=Q9NXV6 Q9NXV6 CDKN2AIP PTHR16148:SF11 NF-KAPPA-B-REPRESSING FACTOR-RELATED CDKN2A-INTERACTING PROTEIN regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;cellular response to stress#GO:0033554;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;response to stress#GO:0006950;regulation of response to stimulus#GO:0048583;DNA damage response#GO:0006974 cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HUMAN|HGNC=6329|UniProtKB=P43626 P43626 KIR2DL1 PTHR11738:SF189 MHC CLASS I NK CELL RECEPTOR IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN-RELATED transmembrane signaling receptor activity#GO:0004888;immune receptor activity#GO:0140375;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;immune response-regulating signaling pathway#GO:0002764;signal transduction#GO:0007165;regulation of biological process#GO:0050789;biological regulation#GO:0065007;signaling#GO:0023052;immune response-regulating cell surface receptor signaling pathway#GO:0002768;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;response to stimulus#GO:0050896;regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166;regulation of immune response#GO:0050776;cell communication#GO:0007154 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=19349|UniProtKB=Q7Z4S6 Q7Z4S6 KIF21A PTHR24115:SF398 KINESIN-RELATED KINESIN-LIKE PROTEIN KIF21A protein binding#GO:0005515;ATP-dependent activity#GO:0140657;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;cytoskeletal motor activity#GO:0003774;cytoskeletal protein binding#GO:0008092;hydrolase activity, acting on acid anhydrides#GO:0016817;ATP hydrolysis activity#GO:0016887;microtubule motor activity#GO:0003777;hydrolase activity#GO:0016787;microtubule binding#GO:0008017;polypeptide conformation or assembly isomerase activity#GO:0120544;ribonucleoside triphosphate phosphatase activity#GO:0017111;isomerase activity#GO:0016853;macromolecular conformation isomerase activity#GO:0120543;tubulin binding#GO:0015631;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824 microtubule-based process#GO:0007017;microtubule-based movement#GO:0007018;cellular process#GO:0009987 supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;microtubule associated complex#GO:0005875;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cytoskeleton#GO:0005856;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microtubule#GO:0005874;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=6934|UniProtKB=P43121 P43121 MCAM PTHR11973:SF18 CELL SURFACE GLYCOPROTEIN MUC18-RELATED CELL SURFACE GLYCOPROTEIN MUC18 cellular process#GO:0009987;multicellular organismal process#GO:0032501;tube development#GO:0035295;developmental process#GO:0032502;multicellular organism development#GO:0007275;vasculature development#GO:0001944;anatomical structure formation involved in morphogenesis#GO:0048646;blood vessel morphogenesis#GO:0048514;anatomical structure morphogenesis#GO:0009653;blood vessel development#GO:0001568;tube morphogenesis#GO:0035239;circulatory system development#GO:0072359;animal gross anatomical part developmental process#GO:0160108;cell adhesion#GO:0007155;angiogenesis#GO:0001525;anatomical structure development#GO:0048856;system development#GO:0048731 membrane#GO:0016020;extracellular region#GO:0005576;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;immunoglobulin superfamily cell adhesion molecule#PC00125 HUMAN|HGNC=7713|UniProtKB=O75380 O75380 NDUFS6 PTHR13156:SF0 NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-A SUBUNIT NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 6, MITOCHONDRIAL aerobic respiration#GO:0009060;cellular respiration#GO:0045333;energy derivation by oxidation of organic compounds#GO:0015980;oxidative phosphorylation#GO:0006119;ATP synthesis coupled electron transport#GO:0042773;mitochondrial electron transport, NADH to ubiquinone#GO:0006120;generation of precursor metabolites and energy#GO:0006091;aerobic electron transport chain#GO:0019646;metabolic process#GO:0008152;cellular process#GO:0009987;respiratory electron transport chain#GO:0022904;mitochondrial ATP synthesis coupled electron transport#GO:0042775;electron transport chain#GO:0022900 transmembrane transporter complex#GO:1902495;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;organelle envelope#GO:0031967;mitochondrion#GO:0005739;transporter complex#GO:1990351;organelle membrane#GO:0031090;respiratory chain complex I#GO:0045271;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;oxidoreductase complex#GO:1990204;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrial membrane#GO:0031966;respiratory chain complex#GO:0098803 oxidoreductase#PC00176 HUMAN|HGNC=17939|UniProtKB=Q9Y2W3 Q9Y2W3 SLC45A1 PTHR19432:SF6 SUGAR TRANSPORTER PROTON-ASSOCIATED SUGAR TRANSPORTER A symporter activity#GO:0015293;solute:proton symporter activity#GO:0015295;carbohydrate transmembrane transporter activity#GO:0015144;monoatomic cation transmembrane transporter activity#GO:0008324;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;proton transmembrane transporter activity#GO:0015078;active transmembrane transporter activity#GO:0022804;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294 membrane#GO:0016020;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258 HUMAN|HGNC=2632|UniProtKB=P24903 P24903 CYP2F1 PTHR24300:SF275 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 2F1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen#GO:0016712;oxidoreductase activity#GO:0016491;monooxygenase activity#GO:0004497;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;heme binding#GO:0020037;tetrapyrrole binding#GO:0046906;binding#GO:0005488 metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;unsaturated fatty acid metabolic process#GO:0033559;lipid metabolic process#GO:0006629;long-chain fatty acid metabolic process#GO:0001676;cellular process#GO:0009987;response to chemical#GO:0042221;icosanoid metabolic process#GO:0006690;cellular response to xenobiotic stimulus#GO:0071466;cellular response to chemical stimulus#GO:0070887;oxoacid metabolic process#GO:0043436;response to xenobiotic stimulus#GO:0009410;olefinic compound metabolic process#GO:0120254;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;arachidonate metabolic process#GO:0019369;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;small molecule metabolic process#GO:0044281;xenobiotic metabolic process#GO:0006805 intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 oxygenase#PC00177;oxidoreductase#PC00176 HUMAN|HGNC=28035|UniProtKB=Q5SWH9 Q5SWH9 TMEM69 PTHR15887:SF4 TRANSMEMBRANE PROTEIN 69 TRANSMEMBRANE PROTEIN 69 HUMAN|HGNC=16852|UniProtKB=O75159 O75159 SOCS5 PTHR10155:SF15 PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT SUPPRESSOR OF CYTOKINE SIGNALING 5 signal transduction#GO:0007165;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signaling#GO:0023052;biological regulation#GO:0065007;response to chemical#GO:0042221;response to stimulus#GO:0050896;response to cytokine#GO:0034097;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;cytokine-mediated signaling pathway#GO:0019221;response to peptide#GO:1901652;cell communication#GO:0007154 kinase modulator#PC00140 Interferon-gamma signaling pathway#P00035>SOCS#P00956;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>SOCS#P00879 HUMAN|HGNC=23443|UniProtKB=A6NDA9 A6NDA9 LRIT2 PTHR45842:SF14 SYNAPTIC ADHESION-LIKE MOLECULE SALM LEUCINE-RICH REPEAT, IMMUNOGLOBULIN-LIKE DOMAIN AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 2 cell adhesion molecule#PC00069;immunoglobulin superfamily cell adhesion molecule#PC00125 HUMAN|HGNC=3012|UniProtKB=Q12882 Q12882 DPYD PTHR43073:SF5 DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)] DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)] purine nucleotide binding#GO:0017076;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;heterocyclic compound binding#GO:1901363;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;nucleoside phosphate binding#GO:1901265;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627 nucleobase-containing small molecule metabolic process#GO:0055086;nucleobase metabolic process#GO:0009112;pyrimidine nucleobase metabolic process#GO:0006206;metabolic process#GO:0008152;nucleobase catabolic process#GO:0046113;nucleobase-containing compound metabolic process#GO:0006139;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;pyrimidine-containing compound metabolic process#GO:0072527;cellular process#GO:0009987;primary metabolic process#GO:0044238;pyrimidine nucleobase catabolic process#GO:0006208 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 dehydrogenase#PC00092;oxidoreductase#PC00176 Pyrimidine Metabolism#P02771>Dihydrouracil Dehydrogenase#P03128 HUMAN|HGNC=16136|UniProtKB=Q9H4G8 Q9H4G8 DPH3P1 PTHR21454:SF23 DPH3 HOMOLOG-RELATED DPH3 HOMOLOG B-RELATED transition metal ion binding#GO:0046914;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;cation binding#GO:0043169;iron ion binding#GO:0005506;metal ion binding#GO:0046872 macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein modification process#GO:0036211;metabolic process#GO:0008152 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=14685|UniProtKB=Q9Y624 Q9Y624 F11R PTHR45113:SF1 JUNCTIONAL ADHESION MOLECULE A JUNCTIONAL ADHESION MOLECULE A cell development#GO:0048468;cell differentiation#GO:0030154;animal gross anatomical part developmental process#GO:0160108;regulation of biological quality#GO:0065008;anatomical structure development#GO:0048856;cellular process#GO:0009987;biological regulation#GO:0065007;tissue development#GO:0009888;multicellular organismal process#GO:0032501;epithelial cell differentiation#GO:0030855;digestion#GO:0007586;regulation of membrane permeability#GO:0090559;epithelium development#GO:0060429;developmental process#GO:0032502;endothelial cell differentiation#GO:0045446;system process#GO:0003008;cellular developmental process#GO:0048869 cell-cell junction#GO:0005911;apical junction complex#GO:0043296;anchoring junction#GO:0070161;cellular anatomical structure#GO:0110165;tight junction#GO:0070160;cell junction#GO:0030054;bicellular tight junction#GO:0005923 cell adhesion molecule#PC00069 HUMAN|HGNC=23219|UniProtKB=Q58DX5 Q58DX5 NAALADL2 PTHR10404:SF32 N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE INACTIVE N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE-LIKE PROTEIN 2 exopeptidase activity#GO:0008238;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;carboxypeptidase activity#GO:0004180;catalytic activity#GO:0003824 metalloprotease#PC00153 HUMAN|HGNC=12993|UniProtKB=P98182 P98182 ZNF200 PTHR47772:SF1 ZINC FINGER PROTEIN 200 ZINC FINGER PROTEIN 200 HUMAN|HGNC=11809|UniProtKB=P35590 P35590 TIE1 PTHR24416:SF341 TYROSINE-PROTEIN KINASE RECEPTOR TYROSINE-PROTEIN KINASE RECEPTOR TIE-1 protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein tyrosine kinase activity#GO:0004714;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein tyrosine kinase activity#GO:0004713 regulation of developmental process#GO:0050793;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of multicellular organismal development#GO:2000026;cellular response to stimulus#GO:0051716;positive regulation of multicellular organismal process#GO:0051240;regulation of biological process#GO:0050789;positive regulation of angiogenesis#GO:0045766;regulation of angiogenesis#GO:0045765;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;regulation of anatomical structure morphogenesis#GO:0022603;cell surface receptor signaling pathway#GO:0007166;positive regulation of developmental process#GO:0051094;regulation of vasculature development#GO:1901342 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;signaling receptor complex#GO:0043235;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=10889|UniProtKB=O95343 O95343 SIX3 PTHR10390:SF31 HOMEOBOX PROTEIN SIX HOMEOBOX PROTEIN SIX3 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;central nervous system development#GO:0007417;regulation of transcription by RNA polymerase II#GO:0006357;visual system development#GO:0150063;regulation of biological process#GO:0050789;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;eye development#GO:0001654;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;brain development#GO:0007420;head development#GO:0060322;nervous system development#GO:0007399;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;sensory system development#GO:0048880;regulation of primary metabolic process#GO:0080090;regulation of biosynthetic process#GO:0009889;animal organ development#GO:0048513;multicellular organism development#GO:0007275;regulation of gene expression#GO:0010468;sensory organ development#GO:0007423;developmental process#GO:0032502 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667 homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 HUMAN|HGNC=13702|UniProtKB=Q96CA5 Q96CA5 BIRC7 PTHR10044:SF163 INHIBITOR OF APOPTOSIS BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 7 ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;enzyme regulator activity#GO:0030234;catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;molecular function regulator activity#GO:0098772;catalytic activity, acting on a protein#GO:0140096 positive regulation of protein metabolic process#GO:0051247;regulation of post-translational protein modification#GO:1901873;positive regulation of metabolic process#GO:0009893;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;regulation of protein modification by small protein conjugation or removal#GO:1903320;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of cell cycle#GO:0051726;negative regulation of cellular process#GO:0048523;regulation of apoptotic process#GO:0042981;regulation of protein ubiquitination#GO:0031396;regulation of protein modification process#GO:0031399;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;negative regulation of programmed cell death#GO:0043069;negative regulation of apoptotic process#GO:0043066;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of protein ubiquitination#GO:0031398;biological regulation#GO:0065007 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634 protein-binding activity modulator#PC00095;protease inhibitor#PC00191 HUMAN|HGNC=5593|UniProtKB=P0DP02 P0DP02 IGHV3-30-3 PTHR23266:SF241 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 3-30-RELATED binding#GO:0005488;antigen binding#GO:0003823 leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;immune system process#GO:0002376;immune effector process#GO:0002252;response to stimulus#GO:0050896;adaptive immune response#GO:0002250;immune response#GO:0006955 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=17789|UniProtKB=Q9NUP9 Q9NUP9 LIN7C PTHR14063:SF5 PROTEIN LIN-7 HOMOLOG PROTEIN LIN-7 HOMOLOG C protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 synaptic vesicle transport#GO:0048489;synaptic signaling#GO:0099536;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;synaptic vesicle localization#GO:0097479;neurotransmitter transport#GO:0006836;establishment of vesicle localization#GO:0051650;regulation of synapse organization#GO:0050807;cellular localization#GO:0051641;regulation of biological quality#GO:0065008;secretion by cell#GO:0032940;regulation of biological process#GO:0050789;establishment of organelle localization#GO:0051656;regulation of cellular component organization#GO:0051128;regulation of cellular component biogenesis#GO:0044087;export from cell#GO:0140352;signaling#GO:0023052;transport#GO:0006810;establishment of localization#GO:0051234;vesicle localization#GO:0051648;regulation of synapse assembly#GO:0051963;neurotransmitter secretion#GO:0007269;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;trans-synaptic signaling#GO:0099537;organelle localization#GO:0051640;signal release#GO:0023061;regulation of cell junction assembly#GO:1901888;secretion#GO:0046903;regulation of synapse structure or activity#GO:0050803;localization#GO:0051179;cell communication#GO:0007154;signal release from synapse#GO:0099643;chemical synaptic transmission#GO:0007268;regulation of growth#GO:0040008;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;regulation of developmental process#GO:0050793 adherens junction#GO:0005912;anchoring junction#GO:0070161;cell junction#GO:0030054;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;synapse#GO:0045202;protein-containing complex#GO:0032991;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane protein complex#GO:0098796;cell-cell junction#GO:0005911;membrane#GO:0016020 cell junction protein#PC00070 HUMAN|HGNC=33742|UniProtKB=Q5BKX8 Q5BKX8 CAVIN4 PTHR15240:SF4 CAVIN CAVEOLAE-ASSOCIATED PROTEIN 4 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007 membrane raft#GO:0045121;membrane#GO:0016020;caveola#GO:0005901;cell periphery#GO:0071944;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cytoplasm#GO:0005737;membrane microdomain#GO:0098857;plasma membrane raft#GO:0044853;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HUMAN|HGNC=2653|UniProtKB=Q9UNU6 Q9UNU6 CYP8B1 PTHR24306:SF0 FAMILY NOT NAMED 7-ALPHA-HYDROXYCHOLEST-4-EN-3-ONE 12-ALPHA-HYDROXYLASE oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen#GO:0016712;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;steroid hydroxylase activity#GO:0008395;catalytic activity#GO:0003824;monooxygenase activity#GO:0004497 HUMAN|HGNC=14701|UniProtKB=Q8NGS9 Q8NGS9 OR13C2 PTHR26453:SF616 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 13C2 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 system process#GO:0003008;sensory perception#GO:0007600;nervous system process#GO:0050877;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;response to stimulus#GO:0050896;response to chemical#GO:0042221;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;detection of chemical stimulus#GO:0009593;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=1505|UniProtKB=P49662 P49662 CASP4 PTHR10454:SF13 CASPASE CASPASE-4 catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;endopeptidase activity#GO:0004175;cysteine-type endopeptidase activity#GO:0004197;peptidase activity#GO:0008233 positive regulation of response to external stimulus#GO:0032103;positive regulation of apoptotic process#GO:0043065;defense response#GO:0006952;positive regulation of inflammatory response#GO:0050729;regulation of response to stress#GO:0080134;positive regulation of neuron apoptotic process#GO:0043525;regulation of apoptotic process#GO:0042981;regulation of response to stimulus#GO:0048583;positive regulation of defense response#GO:0031349;regulation of response to external stimulus#GO:0032101;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;response to stress#GO:0006950;regulation of neuron apoptotic process#GO:0043523;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of defense response#GO:0031347;regulation of inflammatory response#GO:0050727;inflammatory response#GO:0006954;regulation of cellular process#GO:0050794;positive regulation of programmed cell death#GO:0043068;response to stimulus#GO:0050896;programmed cell death#GO:0012501;regulation of programmed cell death#GO:0043067;apoptotic process#GO:0006915;cell death#GO:0008219;regulation of biological process#GO:0050789 canonical inflammasome complex#GO:0061702;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 protease#PC00190;protein modifying enzyme#PC00260 HUMAN|HGNC=29961|UniProtKB=P61366 P61366 OSTN PTHR35353:SF1 OSTEOCRIN OSTEOCRIN protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488 cellular response to chemical stimulus#GO:0070887;hormone-mediated signaling pathway#GO:0009755;cell communication#GO:0007154;response to endogenous stimulus#GO:0009719;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cellular response to hormone stimulus#GO:0032870;regulation of cellular process#GO:0050794;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;signaling#GO:0023052;response to hormone#GO:0009725;cellular process#GO:0009987;signal transduction#GO:0007165;response to chemical#GO:0042221;biological regulation#GO:0065007 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=22937|UniProtKB=Q86W25 Q86W25 NLRP13 PTHR45690:SF16 NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12 NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 13 biological regulation#GO:0065007;regulation of response to external stimulus#GO:0032101;regulation of inflammatory response#GO:0050727;regulation of response to stimulus#GO:0048583;regulation of defense response#GO:0031347;regulation of biological process#GO:0050789;regulation of response to stress#GO:0080134 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090 HUMAN|HGNC=16740|UniProtKB=O95625 O95625 ZBTB11 PTHR24384:SF196 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 11 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218 HUMAN|HGNC=28591|UniProtKB=Q96MH2 Q96MH2 HEXIM2 PTHR13469:SF3 HEXAMETHYLENE BISACETAMIDE INDUCIBLE 1 PROTEIN HEXIM2 enzyme inhibitor activity#GO:0004857;cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538;protein kinase regulator activity#GO:0019887;cyclin-dependent protein kinase regulator activity#GO:0019914;protein kinase inhibitor activity#GO:0004860;kinase regulator activity#GO:0019207;cyclin-dependent protein serine/threonine kinase inhibitor activity#GO:0004861;molecular function regulator activity#GO:0098772;kinase inhibitor activity#GO:0019210;binding#GO:0005488;nucleic acid binding#GO:0003676;molecular function inhibitor activity#GO:0140678;snRNA binding#GO:0017069;enzyme regulator activity#GO:0030234;RNA binding#GO:0003723 regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=26004|UniProtKB=Q9H9A6 Q9H9A6 LRRC40 PTHR45752:SF160 LEUCINE-RICH REPEAT-CONTAINING LEUCINE-RICH REPEAT-CONTAINING PROTEIN 40 signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 scaffold/adaptor protein#PC00226 HUMAN|HGNC=13177|UniProtKB=Q9UKS7 Q9UKS7 IKZF2 PTHR24404:SF33 ZINC FINGER PROTEIN ZINC FINGER PROTEIN HELIOS sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218 HUMAN|HGNC=4862|UniProtKB=P55160 P55160 NCKAP1L PTHR12093:SF9 NCK-ASSOCIATED PROTEIN 1 NCK-ASSOCIATED PROTEIN 1-LIKE multicellular organismal process#GO:0032501;cell migration#GO:0016477;plasma membrane bounded cell projection organization#GO:0120036;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;cell motility#GO:0048870;actin cytoskeleton organization#GO:0030036;cortical cytoskeleton organization#GO:0030865;actin filament-based process#GO:0030029;anatomical structure development#GO:0048856;cortical actin cytoskeleton organization#GO:0030866;system development#GO:0048731;organelle organization#GO:0006996;neuron projection development#GO:0031175;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component assembly#GO:0022607;nervous system development#GO:0007399;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cell projection morphogenesis#GO:0048858;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell development#GO:0048468;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;neuron development#GO:0048666 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 HUMAN|HGNC=8139|UniProtKB=O95948 O95948 ONECUT2 PTHR14057:SF10 TRANSCRIPTION FACTOR ONECUT ONE CUT DOMAIN FAMILY MEMBER 2 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119 HUMAN|HGNC=4312|UniProtKB=P48507 P48507 GCLM PTHR13295:SF4 GLUTAMATE CYSTEINE LIGASE REGULATORY SUBUNIT GLUTAMATE--CYSTEINE LIGASE REGULATORY SUBUNIT protein binding#GO:0005515;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;binding#GO:0005488;enzyme binding#GO:0019899 cellular process#GO:0009987;metabolic process#GO:0008152;glutathione metabolic process#GO:0006749;sulfur compound metabolic process#GO:0006790;modified amino acid metabolic process#GO:0006575;biosynthetic process#GO:0009058;peptide metabolic process#GO:0006518 catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 ligase#PC00142;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=28714|UniProtKB=Q6UX72 Q6UX72 B3GNT9 PTHR11214:SF91 BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE UDP-GLCNAC:BETAGAL BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE 9 UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;transferase activity#GO:0016740 macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;aminoglycan metabolic process#GO:0006022;metabolic process#GO:0008152;biosynthetic process#GO:0009058;aminoglycan biosynthetic process#GO:0006023;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622 transferase#PC00220;glycosyltransferase#PC00111 HUMAN|HGNC=2469|UniProtKB=P21291 P21291 CSRP1 PTHR24215:SF23 RHO-GTPASE-ACTIVATING PROTEIN LRG1 CYSTEINE AND GLYCINE-RICH PROTEIN 1 structural molecule activity#GO:0005198;protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;binding#GO:0005488 developmental process#GO:0032502;cellular developmental process#GO:0048869;tissue development#GO:0009888;sarcomere organization#GO:0045214;actin filament-based process#GO:0030029;cellular component assembly involved in morphogenesis#GO:0010927;organelle assembly#GO:0070925;supramolecular fiber organization#GO:0097435;muscle tissue development#GO:0060537;anatomical structure development#GO:0048856;myofibril assembly#GO:0030239;muscle cell differentiation#GO:0042692;muscle cell development#GO:0055001;actin cytoskeleton organization#GO:0030036;muscle structure development#GO:0061061;cellular anatomical entity morphogenesis#GO:0032989;striated muscle cell differentiation#GO:0051146;anatomical structure formation involved in morphogenesis#GO:0048646;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;animal gross anatomical part developmental process#GO:0160108;striated muscle cell development#GO:0055002;anatomical structure morphogenesis#GO:0009653;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;cell development#GO:0048468;actomyosin structure organization#GO:0031032;cell differentiation#GO:0030154 cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;Z disc#GO:0030018;nucleus#GO:0005634;contractile muscle fiber#GO:0043292;membraneless organelle#GO:0043228;sarcomere#GO:0030017;I band#GO:0031674;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membrane-bounded organelle#GO:0043227;myofibril#GO:0030016;intracellular organelle#GO:0043229 actin or actin-binding cytoskeletal protein#PC00041;cytoskeletal protein#PC00085 HUMAN|HGNC=25952|UniProtKB=Q9NXS2 Q9NXS2 QPCTL PTHR12283:SF6 GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE-LIKE PROTEIN cation binding#GO:0043169;metal ion binding#GO:0046872;transition metal ion binding#GO:0046914;ion binding#GO:0043167;acyltransferase activity#GO:0016746;small molecule binding#GO:0036094;binding#GO:0005488;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;zinc ion binding#GO:0008270;transferase activity#GO:0016740;catalytic activity#GO:0003824 transferase#PC00220 HUMAN|HGNC=20870|UniProtKB=Q9H7B2 Q9H7B2 RPF2 PTHR12728:SF0 BRIX DOMAIN CONTAINING PROTEIN RIBOSOME PRODUCTION FACTOR 2 HOMOLOG binding#GO:0005488;nucleic acid binding#GO:0003676;rRNA binding#GO:0019843;RNA binding#GO:0003723 macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;maturation of LSU-rRNA#GO:0000470;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;ribosomal large subunit biogenesis#GO:0042273;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 intracellular organelle#GO:0043229;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981 HUMAN|HGNC=12015|UniProtKB=P07202 P07202 TPO PTHR11475:SF60 OXIDASE/PEROXIDASE THYROID PEROXIDASE oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on peroxide as acceptor#GO:0016684;catalytic activity#GO:0003824;antioxidant activity#GO:0016209;peroxidase activity#GO:0004601;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705 metabolic process#GO:0008152;regulation of biological quality#GO:0065008;modified amino acid metabolic process#GO:0006575;phenol-containing compound metabolic process#GO:0018958;cellular process#GO:0009987;regulation of hormone levels#GO:0010817;hormone metabolic process#GO:0042445;biological regulation#GO:0065007 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;peroxidase#PC00180 HUMAN|HGNC=10924|UniProtKB=O15427 O15427 SLC16A3 PTHR11360:SF27 MONOCARBOXYLATE TRANSPORTER MONOCARBOXYLATE TRANSPORTER 4 proton transmembrane transporter activity#GO:0015078;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;solute:monoatomic cation symporter activity#GO:0015294;monoatomic ion transmembrane transporter activity#GO:0015075;active transmembrane transporter activity#GO:0022804;monocarboxylic acid transmembrane transporter activity#GO:0008028;solute:proton symporter activity#GO:0015295;symporter activity#GO:0015293;carboxylic acid transmembrane transporter activity#GO:0046943;monoatomic cation transmembrane transporter activity#GO:0008324 basal plasma membrane#GO:0009925;cell periphery#GO:0071944;basolateral plasma membrane#GO:0016323;basal part of cell#GO:0045178;membrane#GO:0016020;plasma membrane#GO:0005886;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165 transporter#PC00227 HUMAN|HGNC=4510|UniProtKB=Q969F8 Q969F8 KISS1R PTHR24230:SF78 G-PROTEIN COUPLED RECEPTOR KISS-1 RECEPTOR G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888;neuropeptide receptor activity#GO:0008188;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653 regulation of transport#GO:0051049;regulation of localization#GO:0032879;cellular process#GO:0009987;positive regulation of secretion by cell#GO:1903532;positive regulation of biological process#GO:0048518;positive regulation of transport#GO:0051050;positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165;biological regulation#GO:0065007;regulation of signaling#GO:0023051;positive regulation of hormone secretion#GO:0046887;positive regulation of secretion#GO:0051047;G protein-coupled receptor signaling pathway#GO:0007186;regulation of biological quality#GO:0065008;regulation of secretion by cell#GO:1903530;positive regulation of signaling#GO:0023056;regulation of hormone secretion#GO:0046883;regulation of secretion#GO:0051046;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of hormone levels#GO:0010817;regulation of biological process#GO:0050789;neuropeptide signaling pathway#GO:0007218;regulation of cell communication#GO:0010646;signaling#GO:0023052;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021 HUMAN|HGNC=23447|UniProtKB=Q5VT03 Q5VT03 NUTM2D PTHR22879:SF14 NUT FAMILY MEMBER 1 NUT FAMILY MEMBER 2A-RELATED HUMAN|HGNC=7877|UniProtKB=A5YKK6 A5YKK6 CNOT1 PTHR13162:SF8 CCR4-NOT TRANSCRIPTION COMPLEX CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1 nucleic acid catabolic process#GO:0141188;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;nucleobase-containing compound catabolic process#GO:0034655;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;positive regulation of catabolic process#GO:0009896;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;macromolecule metabolic process#GO:0043170;positive regulation of mRNA catabolic process#GO:0061014;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA stability#GO:0043487;regulation of RNA metabolic process#GO:0051252;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;RNA destabilization#GO:0050779;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of mRNA metabolic process#GO:1903313;macromolecule catabolic process#GO:0009057;mRNA destabilization#GO:0061157;metabolic process#GO:0008152;regulation of mRNA metabolic process#GO:1903311;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;regulation of mRNA stability#GO:0043488;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;RNA catabolic process#GO:0006401;regulation of biological quality#GO:0065008;RNA metabolic process#GO:0016070;positive regulation of metabolic process#GO:0009893 P-body#GO:0000932;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;CCR4-NOT complex#GO:0030014;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;protein-containing complex#GO:0032991;organelle#GO:0043226;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232 mRNA polyadenylation factor#PC00146 HUMAN|HGNC=24476|UniProtKB=Q9Y2H0 Q9Y2H0 DLGAP4 PTHR12353:SF19 DISKS LARGE-ASSOCIATED PROTEIN DAP SAP90/PSD-95-ASSOCIATED PROTEIN DISKS LARGE-ASSOCIATED PROTEIN 4 biological regulation#GO:0065007;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;regulation of trans-synaptic signaling#GO:0099177;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of signaling#GO:0023051 glutamatergic synapse#GO:0098978;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;cell junction#GO:0030054;postsynaptic specialization#GO:0099572;postsynapse#GO:0098794 scaffold/adaptor protein#PC00226 HUMAN|HGNC=28336|UniProtKB=Q9BRU2 Q9BRU2 TCEAL7 PTHR48555:SF2 TRANSCRIPTION ELONGATION FACTOR A PROTEIN-LIKE 8-RELATED TRANSCRIPTION ELONGATION FACTOR A PROTEIN-LIKE 7 HUMAN|HGNC=13202|UniProtKB=Q9P2N4 Q9P2N4 ADAMTS9 PTHR13723:SF33 ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 9 catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 cellular process#GO:0009987;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;external encapsulating structure organization#GO:0045229;protein metabolic process#GO:0019538;extracellular matrix organization#GO:0030198;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;extracellular structure organization#GO:0043062;metabolic process#GO:0008152;proteolysis#GO:0006508 extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 HUMAN|HGNC=21716|UniProtKB=Q7Z443 Q7Z443 PKD1L3 PTHR10877:SF136 POLYCYSTIN FAMILY MEMBER POLYCYSTIN-1-LIKE PROTEIN 3 calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;transporter activity#GO:0005215;passive transmembrane transporter activity#GO:0022803 response to external stimulus#GO:0009605;response to stimulus#GO:0050896;response to mechanical stimulus#GO:0009612;detection of stimulus#GO:0051606;detection of mechanical stimulus#GO:0050982;response to abiotic stimulus#GO:0009628 membrane#GO:0016020;cellular anatomical structure#GO:0110165 ion channel#PC00133 HUMAN|HGNC=22082|UniProtKB=Q3ZAQ7 Q3ZAQ7 VMA21 PTHR31792:SF3 VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21 VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21 protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607 organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum membrane#GO:0005789;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;membrane#GO:0016020 HUMAN|HGNC=21036|UniProtKB=Q9NWS9 Q9NWS9 ZNF446 PTHR23226:SF210 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER PROTEIN 446 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=20856|UniProtKB=Q9NVV9 Q9NVV9 THAP1 PTHR46600:SF14 THAP DOMAIN-CONTAINING THAP DOMAIN-CONTAINING PROTEIN 1 cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=14940|UniProtKB=Q8WVI7 Q8WVI7 PPP1R1C PTHR15417:SF5 PROTEIN PHOSPHATASE INHIBITOR AND DOPAMINE- AND CAMP-REGULATED NEURONAL PHOSPHOPROTEIN PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 1C enzyme inhibitor activity#GO:0004857;protein phosphatase inhibitor activity#GO:0004864;molecular function regulator activity#GO:0098772;phosphatase inhibitor activity#GO:0019212;phosphatase regulator activity#GO:0019208;protein phosphatase regulator activity#GO:0019888;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234 signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 phosphatase inhibitor#PC00183;protein-binding activity modulator#PC00095;phosphatase modulator#PC00184 HUMAN|HGNC=25847|UniProtKB=Q9H832 Q9H832 UBE2Z PTHR46116:SF26 (E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME UBIQUITIN-CONJUGATING ENZYME E2 Z ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-like protein conjugating enzyme activity#GO:0061650;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin conjugating enzyme activity#GO:0061631 negative regulation of cellular process#GO:0048523;regulation of apoptotic process#GO:0042981;negative regulation of apoptotic process#GO:0043066;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;regulation of biological process#GO:0050789;negative regulation of programmed cell death#GO:0043069 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=28840|UniProtKB=O95521 O95521 PRAMEF1 PTHR14224:SF81 SIMILAR TO PREFERENTIALLY EXPRESSED ANTIGEN IN MELANOMA-LIKE 3 PRAME FAMILY MEMBER 1-RELATED protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;enzyme-substrate adaptor activity#GO:0140767;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;cullin-RING ubiquitin ligase complex#GO:0031461;Cul2-RING ubiquitin ligase complex#GO:0031462;catalytic complex#GO:1902494;transferase complex#GO:1990234;ubiquitin ligase complex#GO:0000151;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=4700|UniProtKB=O15488 O15488 GYG2 PTHR11183:SF167 GLYCOGENIN SUBFAMILY MEMBER GLYCOGENIN-2 hexosyltransferase activity#GO:0016758;UDP-glucosyltransferase activity#GO:0035251;transferase activity#GO:0016740;catalytic activity#GO:0003824;glucosyltransferase activity#GO:0046527;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 glycosyltransferase#PC00111;transferase#PC00220 HUMAN|HGNC=31815|UniProtKB=Q8IXL9 Q8IXL9 IQCF2 PTHR21633:SF4 IQ MOTIF CONTAINING F IQ DOMAIN-CONTAINING PROTEIN F2 HUMAN|HGNC=18286|UniProtKB=Q96IS3 Q96IS3 RAX2 PTHR46271:SF2 HOMEOBOX PROTEIN, PUTATIVE-RELATED RETINA AND ANTERIOR NEURAL FOLD HOMEOBOX PROTEIN 2 cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 homeodomain transcription factor#PC00119 HUMAN|HGNC=12137|UniProtKB=A0A0B4J264 A0A0B4J264 TRAV38-1 PTHR23267:SF141 IMMUNOGLOBULIN LIGHT CHAIN T CELL RECEPTOR ALPHA VARIABLE 38-1 response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=4801|UniProtKB=P40939 P40939 HADHA PTHR43612:SF7 TRIFUNCTIONAL ENZYME SUBUNIT ALPHA TRIFUNCTIONAL ENZYME SUBUNIT ALPHA, MITOCHONDRIAL transferase complex#GO:1990234;oxidoreductase complex#GO:1990204;membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=573|UniProtKB=Q9UPM8 Q9UPM8 AP4E1 PTHR22780:SF13 ADAPTIN, ALPHA/GAMMA/EPSILON AP-4 COMPLEX SUBUNIT EPSILON-1 cargo adaptor activity#GO:0140312;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 AP-type membrane coat adaptor complex#GO:0030119;intracellular anatomical structure#GO:0005622;coated membrane#GO:0048475;membrane coat#GO:0030117;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;membrane protein complex#GO:0098796;membrane#GO:0016020 membrane traffic protein#PC00150 HUMAN|HGNC=34236|UniProtKB=A6NKW6 A6NKW6 SHISAL2B PTHR31395:SF2 SHISA PROTEIN SHISA-LIKE-2B scaffold/adaptor protein#PC00226 HUMAN|HGNC=11955|UniProtKB=Q8TF68 Q8TF68 ZNF384 PTHR24376:SF130 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 384 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=31974|UniProtKB=A8MUH7 A8MUH7 PDZK1P1 PTHR14191:SF6 PDZ DOMAIN CONTAINING PROTEIN NA(+)_H(+) EXCHANGE REGULATORY COFACTOR NHE-RF3-RELATED protein binding#GO:0005515;protein-membrane adaptor activity#GO:0043495;signaling receptor binding#GO:0005102;binding#GO:0005488;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 localization within membrane#GO:0051668;protein localization to cell periphery#GO:1990778;intracellular protein localization#GO:0008104;localization#GO:0051179;cellular localization#GO:0051641;cellular process#GO:0009987;protein localization to membrane#GO:0072657;macromolecule localization#GO:0033036;protein localization to plasma membrane#GO:0072659 cell periphery#GO:0071944;apical part of cell#GO:0045177;membrane#GO:0016020;apical plasma membrane#GO:0016324;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590 scaffold/adaptor protein#PC00226 HUMAN|HGNC=1682|UniProtKB=Q08722 Q08722 CD47 PTHR10613:SF0 LEUKOCYTE SURFACE ANTIGEN CD47 LEUKOCYTE SURFACE ANTIGEN CD47 cell adhesion molecule#PC00069 HUMAN|HGNC=5234|UniProtKB=P34931 P34931 HSPA1L PTHR19375:SF210 HEAT SHOCK PROTEIN 70KDA HEAT SHOCK 70 KDA PROTEIN 1-LIKE ribonucleoside triphosphate phosphatase activity#GO:0017111;heat shock protein binding#GO:0031072;hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;ATP hydrolysis activity#GO:0016887;protein binding#GO:0005515;hydrolase activity#GO:0016787;ATP-dependent activity#GO:0140657;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;protein folding#GO:0006457;gene expression#GO:0010467;protein maturation#GO:0051604;metabolic process#GO:0008152;protein refolding#GO:0042026;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cytosol#GO:0005829;nucleus#GO:0005634 Hsp70 family chaperone#PC00027;chaperone#PC00072 Apoptosis signaling pathway#P00006>HSP70#P00321;Parkinson disease#P00049>Hsp70#P01208 HUMAN|HGNC=27230|UniProtKB=Q56NI9 Q56NI9 ESCO2 PTHR45884:SF3 N-ACETYLTRANSFERASE ECO N-ACETYLTRANSFERASE ESCO2 protein N-acyltransferase activity#GO:0140186;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;protein-lysine-acetyltransferase activity#GO:0061733;acetyltransferase activity#GO:0016407;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;protein N-acetyltransferase activity#GO:0034212;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740 chromosome organization#GO:0051276;cellular component organization or biogenesis#GO:0071840;sister chromatid cohesion#GO:0007062;cell cycle process#GO:0022402;cellular process#GO:0009987;cell cycle#GO:0007049;organelle organization#GO:0006996;cellular component organization#GO:0016043;mitotic sister chromatid cohesion#GO:0007064 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 acetyltransferase#PC00038;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=12180|UniProtKB=A0A0K0K1C0 A0A0K0K1C0 TRBV11-1 PTHR23268:SF47 T-CELL RECEPTOR BETA CHAIN T CELL RECEPTOR BETA VARIABLE 11-1 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=6696|UniProtKB=O75096 O75096 LRP4 PTHR24270:SF5 LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 4 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 apolipoprotein#PC00052;transfer/carrier protein#PC00219 Alzheimer disease-presenilin pathway#P00004>LRP transmembrane fragment#P00152;Alzheimer disease-presenilin pathway#P00004>LRP#P00150;Alzheimer disease-presenilin pathway#P00004>LRP C-terminal fragment#P00112;Alzheimer disease-presenilin pathway#P00004>LRP N-terminal fragment#P00169;Alzheimer disease-presenilin pathway#P00004>LRP intracellular fragment#P00173 HUMAN|HGNC=1515|UniProtKB=P20810 P20810 CAST PTHR10077:SF0 CALPASTATIN CALPASTATIN endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772;enzyme inhibitor activity#GO:0004857;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;cysteine-type endopeptidase inhibitor activity#GO:0004869;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414;peptidase regulator activity#GO:0061134 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein-binding activity modulator#PC00095;protease inhibitor#PC00191 HUMAN|HGNC=7392|UniProtKB=P35548 P35548 MSX2 PTHR24338:SF10 HOMEOBOX PROTEIN MSX HOMEOBOX PROTEIN MSX-2 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690 embryo development#GO:0009790;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;embryonic morphogenesis#GO:0048598;multicellular organism development#GO:0007275;developmental process#GO:0032502;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;regulation of RNA metabolic process#GO:0051252;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=17037|UniProtKB=Q8WVM0 Q8WVM0 TFB1M PTHR11727:SF17 DIMETHYLADENOSINE TRANSFERASE DIMETHYLADENOSINE TRANSFERASE 1, MITOCHONDRIAL catalytic activity, acting on a rRNA#GO:0140102;rRNA (adenine) methyltransferase activity#GO:0016433;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;transcription regulator activity#GO:0140110;N-methyltransferase activity#GO:0008170;rRNA methyltransferase activity#GO:0008649;RNA methyltransferase activity#GO:0008173;catalytic activity, acting on RNA#GO:0140098;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a nucleic acid#GO:0140640 DNA-templated transcription initiation#GO:0006352;ribonucleoprotein complex biogenesis#GO:0022613;rRNA modification#GO:0000154;RNA metabolic process#GO:0016070;methylation#GO:0032259;ribosome biogenesis#GO:0042254;macromolecule methylation#GO:0043414;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;gene expression#GO:0010467;RNA processing#GO:0006396;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;rRNA methylation#GO:0031167;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mitochondrial RNA metabolic process#GO:0000959;RNA methylation#GO:0001510;macromolecule modification#GO:0043412;mitochondrial gene expression#GO:0140053;rRNA processing#GO:0006364;mitochondrial transcription#GO:0006390;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;rRNA metabolic process#GO:0016072 intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 RNA methyltransferase#PC00033;RNA metabolism protein#PC00031 HUMAN|HGNC=5473|UniProtKB=P22692 P22692 IGFBP4 PTHR11551:SF7 INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 4 growth factor binding#GO:0019838;protein binding#GO:0005515;binding#GO:0005488 regulation of biological process#GO:0050789;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cell communication#GO:0010646 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protein-binding activity modulator#PC00095;protease inhibitor#PC00191 HUMAN|HGNC=6868|UniProtKB=Q96JE9 Q96JE9 MAP6 PTHR14759:SF29 STOP PROTEIN MICROTUBULE-ASSOCIATED PROTEIN 6 cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;microtubule binding#GO:0008017;binding#GO:0005488;protein binding#GO:0005515 cell projection morphogenesis#GO:0048858;regulation of axonogenesis#GO:0050770;plasma membrane bounded cell projection morphogenesis#GO:0120039;regulation of multicellular organismal process#GO:0051239;regulation of microtubule cytoskeleton organization#GO:0070507;positive regulation of axonogenesis#GO:0050772;dendrite development#GO:0016358;generation of neurons#GO:0048699;positive regulation of cellular component organization#GO:0051130;cell differentiation#GO:0030154;positive regulation of nervous system development#GO:0051962;cell projection organization#GO:0030030;regulation of multicellular organismal development#GO:2000026;cellular component organization#GO:0016043;establishment of localization#GO:0051234;cellular developmental process#GO:0048869;developmental process#GO:0032502;plasma membrane bounded cell projection organization#GO:0120036;system development#GO:0048731;localization#GO:0051179;regulation of nervous system development#GO:0051960;regulation of developmental process#GO:0050793;positive regulation of neurogenesis#GO:0050769;regulation of cytoskeleton organization#GO:0051493;dendrite morphogenesis#GO:0048813;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;regulation of anatomical structure morphogenesis#GO:0022603;neuron differentiation#GO:0030182;positive regulation of cell differentiation#GO:0045597;cell morphogenesis involved in neuron differentiation#GO:0048667;positive regulation of cell development#GO:0010720;nervous system development#GO:0007399;positive regulation of biological process#GO:0048518;regulation of neuron projection development#GO:0010975;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;neuron projection development#GO:0031175;neuron development#GO:0048666;cellular localization#GO:0051641;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;regulation of cellular component organization#GO:0051128;cell morphogenesis#GO:0000902;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;positive regulation of multicellular organismal process#GO:0051240;neurogenesis#GO:0022008;regulation of plasma membrane bounded cell projection organization#GO:0120035;positive regulation of developmental process#GO:0051094;transport#GO:0006810;regulation of cell differentiation#GO:0045595;neuron projection morphogenesis#GO:0048812;regulation of cell projection organization#GO:0031344;intracellular transport#GO:0046907;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;cytoskeleton-dependent intracellular transport#GO:0030705;positive regulation of cellular process#GO:0048522;regulation of cell development#GO:0060284;anatomical structure development#GO:0048856;positive regulation of cell projection organization#GO:0031346;regulation of microtubule-based process#GO:0032886;regulation of cellular process#GO:0050794;regulation of neurogenesis#GO:0050767 vesicle#GO:0031982;intracellular vesicle#GO:0097708;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;dendritic tree#GO:0097447;intracellular organelle#GO:0043229;axon#GO:0030424;dendrite#GO:0030425;supramolecular fiber#GO:0099512;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;microtubule#GO:0005874;neuron projection#GO:0043005;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;somatodendritic compartment#GO:0036477;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;endomembrane system#GO:0012505;Golgi-associated vesicle#GO:0005798;Golgi apparatus#GO:0005794;cytoskeleton#GO:0005856;cis-Golgi network#GO:0005801;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228 HUMAN|HGNC=32460|UniProtKB=A8MTY0 A8MTY0 ZNF724 PTHR24384:SF201 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED ZINC FINGER PROTEIN 100-RELATED sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA-binding transcription factor#PC00218 HUMAN|HGNC=1814|UniProtKB=P13688 P13688 CEACAM1 PTHR44427:SF1 CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 19 CELL ADHESION MOLECULE CEACAM1 protein kinase binding#GO:0019901;enzyme binding#GO:0019899;kinase binding#GO:0019900;binding#GO:0005488;protein tyrosine kinase binding#GO:1990782;protein binding#GO:0005515 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;cell communication#GO:0007154 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cell surface#GO:0009986;cellular anatomical structure#GO:0110165 cell adhesion molecule#PC00069 HUMAN|HGNC=16860|UniProtKB=Q15020 Q15020 SART3 PTHR15481:SF5 RIBONUCLEIC ACID BINDING PROTEIN S1 SPLICEOSOME ASSOCIATED FACTOR 3, U4_U6 RECYCLING PROTEIN RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233 RNA splicing factor#PC00148;RNA metabolism protein#PC00031;RNA processing factor#PC00147 HUMAN|HGNC=5971|UniProtKB=P42701 P42701 IL12RB1 PTHR23036:SF51 CYTOKINE RECEPTOR INTERLEUKIN-12 RECEPTOR SUBUNIT BETA-1 transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488;molecular transducer activity#GO:0060089;protein binding#GO:0005515;cytokine receptor activity#GO:0004896;cytokine binding#GO:0019955;signaling receptor activity#GO:0038023;immune receptor activity#GO:0140375 cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;response to chemical#GO:0042221;response to cytokine#GO:0034097;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;response to peptide#GO:1901652;regulation of cell population proliferation#GO:0042127;cell communication#GO:0007154;cytokine-mediated signaling pathway#GO:0019221;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;cellular response to stimulus#GO:0051716;positive regulation of cell population proliferation#GO:0008284 cell periphery#GO:0071944;signaling receptor complex#GO:0043235;membrane#GO:0016020;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 Interleukin signaling pathway#P00036>Receptor subunit beta#P00974 HUMAN|HGNC=256|UniProtKB=P40394 P40394 ADH7 PTHR43880:SF2 ALCOHOL DEHYDROGENASE ALL-TRANS-RETINOL DEHYDROGENASE [NAD(+)] ADH7 oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;metal ion binding#GO:0046872;cation binding#GO:0043169;all-trans-retinol dehydrogenase (NAD+) activity#GO:0004745;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;transition metal ion binding#GO:0046914;oxidoreductase activity#GO:0016491;alcohol dehydrogenase (NAD+) activity#GO:0004022;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;zinc ion binding#GO:0008270;catalytic activity#GO:0003824 response to toxic substance#GO:0009636;catabolic process#GO:0009056;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;isoprenoid metabolic process#GO:0006720;retinol metabolic process#GO:0042572;terpenoid metabolic process#GO:0006721;hormone metabolic process#GO:0042445;aldehyde catabolic process#GO:0046185;biological regulation#GO:0065007;retinoid metabolic process#GO:0001523;diterpenoid metabolic process#GO:0016101;lipid metabolic process#GO:0006629;response to stimulus#GO:0050896;small molecule metabolic process#GO:0044281;small molecule catabolic process#GO:0044282;carboxylic acid metabolic process#GO:0019752;cellular detoxification of aldehyde#GO:0110095;monocarboxylic acid metabolic process#GO:0032787;regulation of hormone levels#GO:0010817;regulation of biological quality#GO:0065008;olefinic compound metabolic process#GO:0120254;cellular response to chemical stimulus#GO:0070887;oxoacid metabolic process#GO:0043436;cellular detoxification#GO:1990748;response to oxygen-containing compound#GO:1901700;response to chemical#GO:0042221;cellular response to toxic substance#GO:0097237;detoxification#GO:0098754;aldehyde metabolic process#GO:0006081;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;alcohol metabolic process#GO:0006066;metabolic process#GO:0008152 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 dehydrogenase#PC00092 HUMAN|HGNC=19319|UniProtKB=Q9UGN4 Q9UGN4 CD300A PTHR11860:SF121 POLYMERIC-IMMUNOGLOBULIN RECEPTOR CMRF35-LIKE MOLECULE 8 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=10940|UniProtKB=P43004 P43004 SLC1A2 PTHR11958:SF93 SODIUM/DICARBOXYLATE SYMPORTER-RELATED EXCITATORY AMINO ACID TRANSPORTER 2 carboxylic acid transmembrane transporter activity#GO:0046943;amino acid:sodium symporter activity#GO:0005283;solute:sodium symporter activity#GO:0015370;transmembrane transporter activity#GO:0022857;neutral L-amino acid transmembrane transporter activity#GO:0015175;L-amino acid transmembrane transporter activity#GO:0015179;active transmembrane transporter activity#GO:0022804;acidic amino acid transmembrane transporter activity#GO:0015172;sodium ion transmembrane transporter activity#GO:0015081;dicarboxylic acid transmembrane transporter activity#GO:0005310;L-glutamate transmembrane transporter activity#GO:0005313;solute:monoatomic cation symporter activity#GO:0015294;symporter activity#GO:0015293;monoatomic cation transmembrane transporter activity#GO:0008324;sodium:dicarboxylate symporter activity#GO:0017153;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;amino acid transmembrane transporter activity#GO:0015171;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075 L-alpha-amino acid transmembrane transport#GO:1902475;import across plasma membrane#GO:0098739;carboxylic acid transmembrane transport#GO:1905039;L-glutamate import#GO:0051938;localization#GO:0051179;amino acid transmembrane transport#GO:0003333;transmembrane transport#GO:0055085;aspartate transmembrane transport#GO:0015810;L-amino acid transport#GO:0015807;nitrogen compound transport#GO:0071705;cellular process#GO:0009987;L-glutamate transmembrane transport#GO:0015813;dicarboxylic acid transport#GO:0006835;acidic amino acid transport#GO:0015800;organic acid transport#GO:0015849;transport#GO:0006810;amino acid transport#GO:0006865;carboxylic acid transport#GO:0046942;C4-dicarboxylate transport#GO:0015740;import into cell#GO:0098657;establishment of localization#GO:0051234 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 primary active transporter#PC00068 Metabotropic glutamate receptor group III pathway#P00039>EAAT#P01036;Ionotropic glutamate receptor pathway#P00037>EAAT#P01011 HUMAN|HGNC=17466|UniProtKB=Q8NBI5 Q8NBI5 SLC43A3 PTHR20765:SF1 SOLUTE CARRIER FAMILY 43 MEMBER 3-RELATED EQUILIBRATIVE NUCLEOBASE TRANSPORTER 1 secondary carrier transporter#PC00258;amino acid transporter#PC00046 HUMAN|HGNC=28711|UniProtKB=Q5T9C9 Q5T9C9 PIP5KL1 PTHR23086:SF46 PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE PHOSPHATIDYLINOSITOL 4-PHOSPHATE 5-KINASE-LIKE PROTEIN 1 phosphotransferase activity, alcohol group as acceptor#GO:0016773;lipid kinase activity#GO:0001727;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphatidylinositol kinase activity#GO:0052742 organophosphate biosynthetic process#GO:0090407;phosphatidylinositol phosphate biosynthetic process#GO:0046854;phospholipid biosynthetic process#GO:0008654;glycerolipid metabolic process#GO:0046486;phospholipid metabolic process#GO:0006644;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474;lipid biosynthetic process#GO:0008610;glycerophospholipid metabolic process#GO:0006650;biosynthetic process#GO:0009058;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transferase#PC00220;kinase#PC00137 HUMAN|HGNC=11005|UniProtKB=P11166 P11166 SLC2A1 PTHR23503:SF51 SOLUTE CARRIER FAMILY 2 SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 1 carbohydrate transmembrane transporter activity#GO:0015144;sugar transmembrane transporter activity#GO:0051119;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 vitamin transport#GO:0051180;carbohydrate transmembrane transport#GO:0034219;import across plasma membrane#GO:0098739;cellular process#GO:0009987;D-glucose transmembrane transport#GO:1904659;transmembrane transport#GO:0055085;import into cell#GO:0098657;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810;carbohydrate transport#GO:0008643 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 secondary carrier transporter#PC00258 Gonadotropin-releasing hormone receptor pathway#P06664>Glut1#G06890;Gonadotropin-releasing hormone receptor pathway#P06664>Glut1#P06724;Gonadotropin-releasing hormone receptor pathway#P06664>Glut1#G06675 HUMAN|HGNC=22448|UniProtKB=O60393 O60393 NOBOX PTHR47060:SF1 HOMEOBOX PROTEIN NOBOX HOMEOBOX PROTEIN NOBOX homeodomain transcription factor#PC00119 HUMAN|HGNC=12861|UniProtKB=Q96NJ6 Q96NJ6 ZFP3 PTHR24381:SF272 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 3 HOMOLOG transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=30510|UniProtKB=Q76KD6 Q76KD6 SPATC1 PTHR22192:SF16 SPERIOLIN SPERIOLIN microtubule cytoskeleton#GO:0015630;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;centrosome#GO:0005813;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=33758|UniProtKB=A6NE02 A6NE02 BTBD17 PTHR24410:SF12 HL07962P-RELATED BTB_POZ DOMAIN-CONTAINING PROTEIN 17 defense/immunity protein#PC00090 HUMAN|HGNC=34431|UniProtKB=Q5I0X4 Q5I0X4 PEX39 PTHR40657:SF1 HYPOTHETICAL PROTEIN LOC681367 PEROXISOMAL BIOGENESIS FACTOR 39 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 organelle organization#GO:0006996;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;intracellular protein transmembrane transport#GO:0065002;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;establishment of protein localization to organelle#GO:0072594;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;protein transmembrane transport#GO:0071806;transport#GO:0006810;intracellular protein transport#GO:0006886;protein transmembrane import into intracellular organelle#GO:0044743;protein localization to organelle#GO:0033365;protein import into peroxisome matrix#GO:0016558;cellular component organization#GO:0016043;cellular localization#GO:0051641;transmembrane transport#GO:0055085;localization#GO:0051179;protein transport#GO:0015031;peroxisomal transport#GO:0043574;peroxisome organization#GO:0007031 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=3647|UniProtKB=P22830 P22830 FECH PTHR11108:SF1 FERROCHELATASE FERROCHELATASE, MITOCHONDRIAL lyase activity#GO:0016829;catalytic activity#GO:0003824 porphyrin-containing compound metabolic process#GO:0006778;pigment biosynthetic process#GO:0046148;metabolic process#GO:0008152;tetrapyrrole metabolic process#GO:0033013;porphyrin-containing compound biosynthetic process#GO:0006779;cellular process#GO:0009987;heme biosynthetic process#GO:0006783;pigment metabolic process#GO:0042440;biosynthetic process#GO:0009058;heme metabolic process#GO:0042168;tetrapyrrole biosynthetic process#GO:0033014 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 lyase#PC00144 Heme biosynthesis#P02746>Ferrochelatase#P02972 HUMAN|HGNC=27619|UniProtKB=Q149M9 Q149M9 NWD1 PTHR45013:SF1 NACHT DOMAIN- AND WD REPEAT-CONTAINING PROTEIN 1 NACHT DOMAIN- AND WD REPEAT-CONTAINING PROTEIN 1 HUMAN|HGNC=8022|UniProtKB=P49902 P49902 NT5C2 PTHR12103:SF17 5'-NUCLEOTIDASE DOMAIN-CONTAINING CYTOSOLIC PURINE 5'-NUCLEOTIDASE transferase activity#GO:0016740;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;transferase activity, transferring phosphorus-containing groups#GO:0016772;nucleotidase activity#GO:0008252;kinase activity#GO:0016301;phosphatase activity#GO:0016791;phosphoric ester hydrolase activity#GO:0042578;nucleobase-containing compound kinase activity#GO:0019205;5'-nucleotidase activity#GO:0008253;phosphotransferase activity, alcohol group as acceptor#GO:0016773;hydrolase activity#GO:0016787 purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;purine ribonucleotide catabolic process#GO:0009154;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;nucleoside phosphate metabolic process#GO:0006753;carbohydrate derivative catabolic process#GO:1901136;nucleoside monophosphate metabolic process#GO:0009123;purine ribonucleoside monophosphate metabolic process#GO:0009167;nucleoside phosphate catabolic process#GO:1901292;catabolic process#GO:0009056;IMP metabolic process#GO:0046040;small molecule metabolic process#GO:0044281;purine nucleotide catabolic process#GO:0006195;ribonucleotide metabolic process#GO:0009259;nucleotide metabolic process#GO:0009117;organophosphate catabolic process#GO:0046434;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;carbohydrate derivative metabolic process#GO:1901135;ribonucleotide catabolic process#GO:0009261;nucleobase-containing compound catabolic process#GO:0034655;organophosphate metabolic process#GO:0019637;nucleobase-containing compound metabolic process#GO:0006139;nucleotide catabolic process#GO:0009166;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;purine nucleoside monophosphate metabolic process#GO:0009126;nucleobase-containing small molecule metabolic process#GO:0055086;purine-containing compound catabolic process#GO:0072523 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 nucleotide phosphatase#PC00173;hydrolase#PC00121;phosphatase#PC00181 HUMAN|HGNC=18410|UniProtKB=O60281 O60281 ZNF292 PTHR15507:SF14 ZINC FINGER PROTEIN RLF ZINC FINGER PROTEIN 292 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=16701|UniProtKB=P19105 P19105 MYL12A PTHR23049:SF74 MYOSIN REGULATORY LIGHT CHAIN 2 MYOSIN REGULATORY LIGHT CHAIN 12A myosin binding#GO:0017022;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515 actin cytoskeleton#GO:0015629;myosin complex#GO:0016459;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=1885|UniProtKB=P01215 P01215 CGA PTHR11509:SF0 GLYCOPROTEIN HORMONE ALPHA CHAIN GLYCOPROTEIN HORMONES ALPHA CHAIN regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 extracellular region#GO:0005576;extracellular protein-containing complex#GO:0140392;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 peptide hormone#PC00179;intercellular signal molecule#PC00207 Thyrotropin-releasing hormone receptor signaling pathway#P04394>Thyrotropin#P04588;Gonadotropin-releasing hormone receptor pathway#P06664>CGA#G06886;Gonadotropin-releasing hormone receptor pathway#P06664>CGA#G06673;Thyrotropin-releasing hormone receptor signaling pathway#P04394>TRH#P04585;Thyrotropin-releasing hormone receptor signaling pathway#P04394>ProTRH (Pro Thyrotropin-releasing Hormone)#P04586 HUMAN|HGNC=6802|UniProtKB=P43358 P43358 MAGEA4 PTHR11736:SF48 MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN MELANOMA-ASSOCIATED ANTIGEN 4 histone deacetylase binding#GO:0042826;protein binding#GO:0005515;binding#GO:0005488;enzyme binding#GO:0019899 negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 scaffold/adaptor protein#PC00226 HUMAN|HGNC=23034|UniProtKB=Q6P9H4 Q6P9H4 CNKSR3 PTHR12844:SF17 CONNECTOR ENCHANCER OF KINASE SUPPRESSOR OF RAS CONNECTOR ENHANCER OF KINASE SUPPRESSOR OF RAS 3 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007 scaffold/adaptor protein#PC00226 HUMAN|HGNC=17542|UniProtKB=A6NIE9 A6NIE9 PRSS29P PTHR24256:SF441 TRYPTASE-RELATED SERINE PROTEASE 29-RELATED serine-type peptidase activity#GO:0008236;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;proteolysis#GO:0006508;primary metabolic process#GO:0044238;cellular process#GO:0009987 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 serine protease#PC00203 HUMAN|HGNC=21197|UniProtKB=Q7L5A8 Q7L5A8 FA2H PTHR12863:SF23 FATTY ACID HYDROXYLASE FATTY ACID 2-HYDROXYLASE oxidoreductase activity#GO:0016491;monooxygenase activity#GO:0004497;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705 cellular process#GO:0009987;multicellular organismal process#GO:0032501;glial cell differentiation#GO:0010001;lipid biosynthetic process#GO:0008610;oligodendrocyte differentiation#GO:0048709;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;biosynthetic process#GO:0009058;nervous system development#GO:0007399;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;sphingolipid biosynthetic process#GO:0030148;developmental process#GO:0032502;ceramide biosynthetic process#GO:0046513;lipid metabolic process#GO:0006629;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;gliogenesis#GO:0042063;myelination#GO:0042552;neurogenesis#GO:0022008;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;cell differentiation#GO:0030154;central nervous system development#GO:0007417;cell development#GO:0048468;animal gross anatomical part developmental process#GO:0160108;plasma membrane organization#GO:0007009;ceramide metabolic process#GO:0006672;anatomical structure development#GO:0048856;system development#GO:0048731 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 hydroxylase#PC00122;oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=18891|UniProtKB=Q9BYR9 Q9BYR9 KRTAP2-4 PTHR23262:SF7 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 2-2-RELATED structural protein#PC00211 HUMAN|HGNC=28461|UniProtKB=Q9BVI4 Q9BVI4 NOC4L PTHR12455:SF0 NUCLEOLAR COMPLEX PROTEIN 4 NUCLEOLAR COMPLEX PROTEIN 4 HOMOLOG nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;ribosomal small subunit biogenesis#GO:0042274;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000472;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000479;cellular component biogenesis#GO:0044085;RNA processing#GO:0006396;biosynthetic process#GO:0009058;maturation of SSU-rRNA#GO:0030490;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467 intracellular organelle#GO:0043229;preribosome#GO:0030684;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;small-subunit processome#GO:0032040;90S preribosome#GO:0030686;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991 RNA metabolism protein#PC00031 HUMAN|HGNC=3804|UniProtKB=Q9UJU5 Q9UJU5 FOXD3 PTHR11829:SF405 FORKHEAD BOX PROTEIN FORKHEAD BOX PROTEIN D3 RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;winged helix/forkhead transcription factor#PC00246;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=4945|UniProtKB=P05538 P05538 HLA-DQB2 PTHR19944:SF68 MHC CLASS II-RELATED HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DQ BETA 2 CHAIN protein-containing complex binding#GO:0044877;peptide binding#GO:0042277;antigen binding#GO:0003823;binding#GO:0005488 positive regulation of cellular process#GO:0048522;positive regulation of response to stimulus#GO:0048584;regulation of cell adhesion#GO:0030155;biological regulation#GO:0065007;positive regulation of leukocyte cell-cell adhesion#GO:1903039;positive regulation of cell activation#GO:0050867;regulation of leukocyte cell-cell adhesion#GO:1903037;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;positive regulation of cell adhesion#GO:0045785;regulation of immune system process#GO:0002682;regulation of cell-cell adhesion#GO:0022407;regulation of cellular process#GO:0050794;regulation of immune response#GO:0050776;positive regulation of lymphocyte activation#GO:0051251;antigen processing and presentation#GO:0019882;cellular component biogenesis#GO:0044085;positive regulation of cell-cell adhesion#GO:0022409;positive regulation of immune system process#GO:0002684;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of T cell activation#GO:0050870;cellular component assembly#GO:0022607;regulation of T cell activation#GO:0050863;regulation of multicellular organismal process#GO:0051239;positive regulation of leukocyte activation#GO:0002696;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;regulation of leukocyte activation#GO:0002694;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;regulation of biological process#GO:0050789;regulation of cell activation#GO:0050865;positive regulation of multicellular organismal process#GO:0051240;regulation of lymphocyte activation#GO:0051249;immune system process#GO:0002376 cell periphery#GO:0071944;lysosomal membrane#GO:0005765;vesicle membrane#GO:0012506;membrane#GO:0016020;vacuole#GO:0005773;plasma membrane#GO:0005886;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;late endosome#GO:0005770;endomembrane system#GO:0012505;late endosome membrane#GO:0031902;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;lytic vacuole#GO:0000323;vacuolar membrane#GO:0005774;vesicle#GO:0031982;plasma membrane protein complex#GO:0098797;lysosome#GO:0005764;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;lytic vacuole membrane#GO:0098852;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endosome membrane#GO:0010008;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410 major histocompatibility complex protein#PC00149 HUMAN|HGNC=22573|UniProtKB=A8MUU1 A8MUU1 FABP5P3 PTHR11955:SF144 FATTY ACID BINDING PROTEIN FATTY ACID-BINDING PROTEIN 5-LIKE PROTEIN 3-RELATED lipid binding#GO:0008289;fatty acid binding#GO:0005504;organic acid binding#GO:0043177;ion binding#GO:0043167;anion binding#GO:0043168;carboxylic acid binding#GO:0031406;small molecule binding#GO:0036094;binding#GO:0005488 transport#GO:0006810;organic acid transport#GO:0015849;carboxylic acid transport#GO:0046942;lipid localization#GO:0010876;monocarboxylic acid transport#GO:0015718;establishment of localization#GO:0051234;localization#GO:0051179;fatty acid transport#GO:0015908;macromolecule localization#GO:0033036;lipid transport#GO:0006869 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;cytosol#GO:0005829 transfer/carrier protein#PC00219 HUMAN|HGNC=8829|UniProtKB=Q9BRX2 Q9BRX2 PELO PTHR10853:SF11 PELOTA PROTEIN PELOTA HOMOLOG molecular sensor activity#GO:0140299;molecular function regulator activity#GO:0098772 macromolecule catabolic process#GO:0009057;translational elongation#GO:0006414;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;organelle organization#GO:0006996;gene expression#GO:0010467;RNA catabolic process#GO:0006401;RNA metabolic process#GO:0016070;cellular component disassembly#GO:0022411;organelle disassembly#GO:1903008;rescue of stalled cytosolic ribosome#GO:0072344;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;protein biosynthetic process#GO:0160307;cytoplasmic translation#GO:0002181;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;nucleic acid catabolic process#GO:0141188;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;nucleobase-containing compound catabolic process#GO:0034655;negative regulation of biosynthetic process#GO:0009890;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;translation#GO:0006412;protein metabolic process#GO:0019538;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056 intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;cytosolic ribosome#GO:0022626;ribosome#GO:0005840;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737 translation release factor#PC00225 HUMAN|HGNC=16938|UniProtKB=Q8TCB0 Q8TCB0 IFI44 PTHR14241:SF3 INTERFERON-INDUCED PROTEIN 44 INTERFERON-INDUCED PROTEIN 44 immune system process#GO:0002376;immune response#GO:0006955;response to stimulus#GO:0050896 HUMAN|HGNC=30430|UniProtKB=Q9UGK3 Q9UGK3 STAP2 PTHR16186:SF11 SIGNAL-TRANSDUCING ADAPTOR PROTEIN-RELATED SIGNAL-TRANSDUCING ADAPTOR PROTEIN 2 scaffold/adaptor protein#PC00226 HUMAN|HGNC=13736|UniProtKB=Q9BZL1 Q9BZL1 UBL5 PTHR13042:SF3 UBIQUITIN-LIKE PROTEIN 5 UBIQUITIN-LIKE PROTEIN 5 mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;protein modification process#GO:0036211;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;macromolecule modification#GO:0043412;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;protein metabolic process#GO:0019538;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cytosol#GO:0005829;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HUMAN|HGNC=17153|UniProtKB=Q9BVN2 Q9BVN2 RUSC1 PTHR15591:SF11 RUN AND SH3 DOMAIN CONTAINING AP-4 COMPLEX ACCESSORY SUBUNIT RUSC1 intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=4289|UniProtKB=P32189 P32189 GK PTHR10196:SF56 SUGAR KINASE GLYCEROL KINASE phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824 organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;biosynthetic process#GO:0009058;alcohol metabolic process#GO:0006066;acylglycerol metabolic process#GO:0006639;metabolic process#GO:0008152;triglyceride metabolic process#GO:0006641;lipid metabolic process#GO:0006629;carbohydrate derivative biosynthetic process#GO:1901137;neutral lipid metabolic process#GO:0006638;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;glycerolipid metabolic process#GO:0046486;small molecule metabolic process#GO:0044281;carbohydrate metabolic process#GO:0005975;organophosphate biosynthetic process#GO:0090407 cytosol#GO:0005829;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 carbohydrate kinase#PC00065;kinase#PC00137 HUMAN|HGNC=5362|UniProtKB=Q02535 Q02535 ID3 PTHR11723:SF16 DNA-BINDING PROTEIN INHIBITOR DNA-BINDING PROTEIN INHIBITOR ID-3 transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;system development#GO:0048731;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;nervous system development#GO:0007399;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;multicellular organism development#GO:0007275;neuron differentiation#GO:0030182;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 DNA-binding transcription factor#PC00218 Gonadotropin-releasing hormone receptor pathway#P06664>Id3#P06711 HUMAN|HGNC=19232|UniProtKB=Q6UXB2 Q6UXB2 CXCL17 PTHR37351:SF1 C-X-C MOTIF CHEMOKINE 17 C-X-C MOTIF CHEMOKINE 17 positive regulation of cell motility#GO:2000147;regulation of chemotaxis#GO:0050920;negative regulation of biological process#GO:0048519;positive regulation of multicellular organismal process#GO:0051240;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;mononuclear cell migration#GO:0071674;immune system process#GO:0002376;cellular response to chemical stimulus#GO:0070887;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of immune system process#GO:0002684;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;regulation of response to external stimulus#GO:0032101;taxis#GO:0042330;response to chemical#GO:0042221;positive regulation of macromolecule metabolic process#GO:0010604;regulation of multicellular organismal process#GO:0051239;negative regulation of response to external stimulus#GO:0032102;positive regulation of response to external stimulus#GO:0032103;cellular response to stimulus#GO:0051716;cell motility#GO:0048870;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;negative regulation of defense response#GO:0031348;positive regulation of cytokine production#GO:0001819;negative regulation of inflammatory response#GO:0050728;regulation of macromolecule metabolic process#GO:0060255;regulation of leukocyte migration#GO:0002685;locomotion#GO:0040011;regulation of inflammatory response#GO:0050727;regulation of defense response#GO:0031347;regulation of granulocyte chemotaxis#GO:0071622;chemotaxis#GO:0006935;macrophage chemotaxis#GO:0048246;positive regulation of chemotaxis#GO:0050921;positive regulation of biosynthetic process#GO:0009891;regulation of cell motility#GO:2000145;cell chemotaxis#GO:0060326;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of cytokine production#GO:0001817;positive regulation of cell migration#GO:0030335;positive regulation of cellular process#GO:0048522;cell migration#GO:0016477;negative regulation of response to stimulus#GO:0048585;positive regulation of response to stimulus#GO:0048584;regulation of locomotion#GO:0040012;biological regulation#GO:0065007;regulation of response to stress#GO:0080134;leukocyte migration#GO:0050900;regulation of response to stimulus#GO:0048583;regulation of cell migration#GO:0030334;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;leukocyte chemotaxis#GO:0030595;myeloid leukocyte migration#GO:0097529;response to external stimulus#GO:0009605;positive regulation of locomotion#GO:0040017;positive regulation of gene expression#GO:0010628 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 chemokine#PC00074 HUMAN|HGNC=21233|UniProtKB=Q5T5N4 Q5T5N4 C6orf118 PTHR34916:SF1 GI:13385330 RIKEN CDNA 1700010I14 GENE HUMAN|HGNC=12907|UniProtKB=Q15973 Q15973 ZNF124 PTHR24381:SF136 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 124-RELATED sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=9018|UniProtKB=Q9C010 Q9C010 PKIB PTHR15416:SF6 CAMP-DEPENDENT PROTEIN KINASE INHIBITOR/PKI CAMP-DEPENDENT PROTEIN KINASE INHIBITOR BETA enzyme inhibitor activity#GO:0004857;molecular function regulator activity#GO:0098772;protein kinase inhibitor activity#GO:0004860;kinase regulator activity#GO:0019207;protein kinase regulator activity#GO:0019887;kinase inhibitor activity#GO:0019210;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 kinase inhibitor#PC00139;kinase modulator#PC00140 HUMAN|HGNC=9986|UniProtKB=P48382 P48382 RFX5 PTHR12619:SF18 RFX TRANSCRIPTION FACTOR FAMILY DNA-BINDING PROTEIN RFX5 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 winged helix/forkhead transcription factor#PC00246 HUMAN|HGNC=9194|UniProtKB=P62487 P62487 POLR2G PTHR12709:SF4 DNA-DIRECTED RNA POLYMERASE II, III DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7 macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;transcription by RNA polymerase II#GO:0006366;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;transcription initiation at RNA polymerase II promoter#GO:0006367;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;DNA-templated transcription initiation#GO:0006352;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;RNA polymerase II, holoenzyme#GO:0016591;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;RNA polymerase II, core complex#GO:0005665;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981 DNA-directed RNA polymerase#PC00019;RNA metabolism protein#PC00031 HUMAN|HGNC=352|UniProtKB=P55008 P55008 AIF1 PTHR10356:SF4 ALLOGRAFT INFLAMMATORY FACTOR-1 ALLOGRAFT INFLAMMATORY FACTOR 1 ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;calcium ion binding#GO:0005509;actin binding#GO:0003779;actin filament binding#GO:0051015;protein binding#GO:0005515;metal ion binding#GO:0046872;cation binding#GO:0043169;protein-containing complex binding#GO:0044877;cytoskeletal protein binding#GO:0008092 actin filament organization#GO:0007015;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection assembly#GO:0120031;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament-based process#GO:0030029;cell projection organization#GO:0030030;actin cytoskeleton organization#GO:0030036;actin filament bundle assembly#GO:0051017;actin filament bundle organization#GO:0061572;cellular component organization#GO:0016043 cell projection membrane#GO:0031253;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;leading edge membrane#GO:0031256;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;actin cytoskeleton#GO:0015629;ruffle#GO:0001726;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;ruffle membrane#GO:0032587;actin filament#GO:0005884;supramolecular complex#GO:0099080;plasma membrane region#GO:0098590;supramolecular polymer#GO:0099081;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;cell leading edge#GO:0031252;membrane#GO:0016020;cell periphery#GO:0071944 calmodulin-related#PC00061;calcium-binding protein#PC00060 HUMAN|HGNC=2942|UniProtKB=Q96DT5 Q96DT5 DNAH11 PTHR10676:SF263 DYNEIN HEAVY CHAIN FAMILY PROTEIN DYNEIN AXONEMAL HEAVY CHAIN 11 isomerase activity#GO:0016853;cytoskeletal motor activity#GO:0003774;macromolecular conformation isomerase activity#GO:0120543;catalytic activity#GO:0003824;microtubule motor activity#GO:0003777;protein binding#GO:0005515;ATP-dependent activity#GO:0140657;binding#GO:0005488;polypeptide conformation or assembly isomerase activity#GO:0120544 cilium or flagellum-dependent cell motility#GO:0001539;cilium movement#GO:0003341;microtubule-based process#GO:0007017;cilium-dependent cell motility#GO:0060285;cellular process#GO:0009987;cilium movement involved in cell motility#GO:0060294;cell motility#GO:0048870;microtubule-based movement#GO:0007018 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;9+2 motile cilium#GO:0097729;cilium#GO:0005929;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;axoneme#GO:0005930;dynein complex#GO:0030286;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;motile cilium#GO:0031514;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;ciliary plasm#GO:0097014;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=30229|UniProtKB=P27469 P27469 G0S2 PTHR15570:SF2 G0/G1 SWITCH PROTEIN 2 G0_G1 SWITCH PROTEIN 2 positive regulation of cellular process#GO:0048522;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of response to stimulus#GO:0048584;regulation of response to stimulus#GO:0048583;positive regulation of extrinsic apoptotic signaling pathway#GO:2001238;apoptotic signaling pathway#GO:0097190;cell death#GO:0008219;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;regulation of extrinsic apoptotic signaling pathway#GO:2001236;programmed cell death#GO:0012501;positive regulation of apoptotic signaling pathway#GO:2001235;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of apoptotic signaling pathway#GO:2001233;cell communication#GO:0007154;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;cell surface receptor signaling pathway#GO:0007166;regulation of apoptotic process#GO:0042981;positive regulation of apoptotic process#GO:0043065;regulation of biological process#GO:0050789;apoptotic process#GO:0006915;regulation of programmed cell death#GO:0043067;signaling#GO:0023052;extrinsic apoptotic signaling pathway#GO:0097191;response to stimulus#GO:0050896;positive regulation of programmed cell death#GO:0043068;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=9137|UniProtKB=Q06265 Q06265 EXOSC9 PTHR11097:SF14 EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN EXOSOME COMPLEX COMPONENT RRP45 mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA 3'-UTR binding#GO:0003730;RNA binding#GO:0003723 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;rRNA processing#GO:0006364;snRNA metabolic process#GO:0016073;negative regulation of macromolecule metabolic process#GO:0010605;macromolecule biosynthetic process#GO:0009059;nucleic acid catabolic process#GO:0141188;nucleobase-containing compound catabolic process#GO:0034655;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;negative regulation of biosynthetic process#GO:0009890;nuclear mRNA surveillance#GO:0071028;negative regulation of cellular process#GO:0048523;rRNA metabolic process#GO:0016072;snRNA processing#GO:0016180;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;maturation of 5.8S rRNA#GO:0000460;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;ribonucleoprotein complex biogenesis#GO:0022613;snRNA 3'-end processing#GO:0034472;RNA catabolic process#GO:0006401;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;RNA metabolic process#GO:0016070;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;mRNA catabolic process#GO:0006402;RNA processing#GO:0006396;gene expression#GO:0010467;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule catabolic process#GO:0009057;RNA 3'-end processing#GO:0031123;cellular component organization or biogenesis#GO:0071840 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 RNA metabolism protein#PC00031;exoribonuclease#PC00099 HUMAN|HGNC=2548|UniProtKB=O60494 O60494 CUBN PTHR47537:SF9 CUBILIN CUBILIN plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=7784|UniProtKB=Q12857 Q12857 NFIA PTHR11492:SF6 NUCLEAR FACTOR I NUCLEAR FACTOR 1 A-TYPE sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HUMAN|HGNC=29601|UniProtKB=Q9BSJ5 Q9BSJ5 MTNAP1 PTHR16270:SF5 HYPOTHETICAL LOC287798 MITOCHONDRIAL NUCLEOID-ASSOCIATED PROTEIN 1 HUMAN|Ensembl=ENSG00000293691.1|UniProtKB=A0ABB0MVG2 A0ABB0MVG2 PTHR15566:SF4 POM121-LIKE POM121-LIKE PROTEIN 1-RELATED HUMAN|HGNC=17574|UniProtKB=Q96L96 Q96L96 ALPK3 PTHR47091:SF1 ALPHA-PROTEIN KINASE 2-RELATED ALPHA-PROTEIN KINASE 3 cellular process#GO:0009987;multicellular organismal process#GO:0032501;tissue development#GO:0009888;heart development#GO:0007507;cardiac muscle cell differentiation#GO:0055007;striated muscle tissue development#GO:0014706;developmental process#GO:0032502;cellular developmental process#GO:0048869;animal organ development#GO:0048513;cardiac muscle tissue development#GO:0048738;multicellular organism development#GO:0007275;striated muscle cell differentiation#GO:0051146;muscle cell development#GO:0055001;muscle cell differentiation#GO:0042692;muscle structure development#GO:0061061;circulatory system development#GO:0072359;cell differentiation#GO:0030154;cell development#GO:0048468;animal gross anatomical part developmental process#GO:0160108;anatomical structure development#GO:0048856;striated muscle cell development#GO:0055002;muscle tissue development#GO:0060537;system development#GO:0048731 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=21234|UniProtKB=A0A3B3IU46 A0A3B3IU46 RAMACL PTHR48168:SF1 RNA GUANINE-7 METHYLTRANSFERASE-ACTIVATING SUBUNIT-LIKE (PSEUDOGENE)-RELATED RNA GUANINE-N7 METHYLTRANSFERASE ACTIVATING SUBUNIT-RELATED enzyme activator activity#GO:0008047;binding#GO:0005488;nucleic acid binding#GO:0003676;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;RNA binding#GO:0003723;enzyme regulator activity#GO:0030234 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226 HUMAN|HGNC=17368|UniProtKB=Q5VVH5 Q5VVH5 IRAK1BP1 PTHR18842:SF2 INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1-BINDING PROTEIN 1 INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1-BINDING PROTEIN 1 HUMAN|HGNC=26693|UniProtKB=Q6ZVT0 Q6ZVT0 TTLL10 PTHR46810:SF1 INACTIVE POLYGLYCYLASE TTLL10 INACTIVE POLYGLYCYLASE TTLL10 catalytic activity, acting on a protein#GO:0140096;ligase activity, forming carbon-nitrogen bonds#GO:0016879;catalytic activity#GO:0003824;ligase activity#GO:0016874 HUMAN|HGNC=13968|UniProtKB=P59922 P59922 OR2B8 PTHR26453:SF636 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2B8 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception#GO:0007600;nervous system process#GO:0050877;response to stimulus#GO:0050896;response to chemical#GO:0042221;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;detection of chemical stimulus#GO:0009593 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=25167|UniProtKB=Q96DZ7 Q96DZ7 TM4SF19 PTHR14198:SF22 TRANSMEMBRANE 4 L6 FAMILY MEMBER 1-RELATED TRANSMEMBRANE 4 L6 FAMILY MEMBER 19 cellular anatomical structure#GO:0110165;membrane#GO:0016020 HUMAN|HGNC=15022|UniProtKB=Q8NHC5 Q8NHC5 OR14A16 PTHR26452:SF806 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 14A16 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 nervous system process#GO:0050877;sensory perception#GO:0007600;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=9002|UniProtKB=P48739 P48739 PITPNB PTHR10658:SF27 PHOSPHATIDYLINOSITOL TRANSFER PROTEIN PHOSPHATIDYLINOSITOL TRANSFER PROTEIN BETA ISOFORM lipid binding#GO:0008289;lipid transfer activity#GO:0120013;binding#GO:0005488;molecular carrier activity#GO:0140104;transporter activity#GO:0005215;cation binding#GO:0043169;intramembrane lipid carrier activity#GO:0140303;anion binding#GO:0043168;small molecule binding#GO:0036094;phosphatidylcholine intramembrane carrier activity#GO:0008525;ion binding#GO:0043167;lipid carrier activity#GO:0005319;phosphatidylinositol transfer activity#GO:0008526;phosphatidylcholine binding#GO:0031210;phosphatidylinositol binding#GO:0035091;phospholipid binding#GO:0005543 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 transporter#PC00227 HUMAN|HGNC=7687|UniProtKB=O00483 O00483 COXFA4 PTHR14256:SF4 NADH-UBIQUINONE OXIDOREDUCTASE MLRQ SUBUNIT CYTOCHROME C OXIDASE SUBUNIT FA4 membrane#GO:0016020;oxidoreductase complex#GO:1990204;respiratory chain complex#GO:0098803;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;transporter complex#GO:1990351;membrane protein complex#GO:0098796;mitochondrion#GO:0005739;cytochrome complex#GO:0070069;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transmembrane transporter complex#GO:1902495;respiratory chain complex IV#GO:0045277;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HUMAN|HGNC=29602|UniProtKB=Q86YL7 Q86YL7 PDPN PTHR47390:SF1 PODOPLANIN PODOPLANIN regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;regulation of cell adhesion#GO:0030155;cell migration#GO:0016477;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of cell-cell adhesion#GO:0022409;cell communication#GO:0007154;cell adhesion#GO:0007155;regulation of platelet aggregation#GO:0090330;regulation of platelet activation#GO:0010543;signaling#GO:0023052;regulation of cellular process#GO:0050794;cell motility#GO:0048870;regulation of cell-cell adhesion#GO:0022407;response to stimulus#GO:0050896;regulation of cell activation#GO:0050865;cellular response to stimulus#GO:0051716;positive regulation of cell adhesion#GO:0045785;regulation of biological process#GO:0050789 HUMAN|HGNC=946|UniProtKB=Q96QZ7 Q96QZ7 MAGI1 PTHR10316:SF12 MEMBRANE ASSOCIATED GUANYLATE KINASE-RELATED MEMBRANE-ASSOCIATED GUANYLATE KINASE, WW AND PDZ DOMAIN-CONTAINING PROTEIN 1 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of protein localization to membrane#GO:1905475;regulation of biological quality#GO:0065008;regulation of protein localization#GO:0032880;regulation of localization#GO:0032879;cell communication#GO:0007154 adherens junction#GO:0005912;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;cell junction#GO:0030054;cell-cell junction#GO:0005911;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;synapse#GO:0045202 HUMAN|HGNC=19819|UniProtKB=Q9HCM4 Q9HCM4 EPB41L5 PTHR23280:SF15 4.1 G PROTEIN BAND 4.1-LIKE PROTEIN 5 positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789;positive regulation of cell adhesion#GO:0045785;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;actomyosin structure organization#GO:0031032;regulation of cellular process#GO:0050794;actin cytoskeleton organization#GO:0030036;regulation of cell adhesion#GO:0030155;actin filament-based process#GO:0030029;cellular component organization or biogenesis#GO:0071840 cell periphery#GO:0071944;membrane#GO:0016020;cell leading edge#GO:0031252;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;leading edge membrane#GO:0031256;ruffle membrane#GO:0032587;ruffle#GO:0001726;cell projection membrane#GO:0031253 non-motor actin binding protein#PC00165;cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=19696|UniProtKB=Q9HAV7 Q9HAV7 GRPEL1 PTHR21237:SF25 GRPE PROTEIN GRPE PROTEIN HOMOLOG 1, MITOCHONDRIAL nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 establishment of localization#GO:0051234;intracellular protein transmembrane transport#GO:0065002;establishment of protein localization to organelle#GO:0072594;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;transport#GO:0006810;protein transmembrane transport#GO:0071806;intracellular protein transport#GO:0006886;protein transmembrane import into intracellular organelle#GO:0044743;protein import into mitochondrial matrix#GO:0030150;mitochondrial protein import pathway#GO:7770058;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular localization#GO:0051641;transmembrane transport#GO:0055085;localization#GO:0051179;protein transport#GO:0015031;mitochondrial transmembrane transport#GO:1990542;protein localization to organelle#GO:0033365;mitochondrial transport#GO:0006839;protein localization to mitochondrion#GO:0070585 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;organelle lumen#GO:0043233;membrane protein complex#GO:0098796;organelle envelope#GO:0031967;organelle membrane#GO:0031090;inner mitochondrial membrane protein complex#GO:0098800;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;TIM23 mitochondrial import inner membrane translocase complex#GO:0005744;mitochondrial membrane#GO:0031966;membrane#GO:0016020;membrane-enclosed lumen#GO:0031974;mitochondrial inner membrane#GO:0005743 transporter#PC00227;primary active transporter#PC00068 HUMAN|HGNC=20893|UniProtKB=Q6W2J9 Q6W2J9 BCOR PTHR24117:SF8 AGAP007537-PB BCL-6 COREPRESSOR transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714;transcription regulator activity#GO:0140110 regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=30961|UniProtKB=O60844 O60844 ZG16 PTHR33589:SF4 OS11G0524900 PROTEIN ZYMOGEN GRANULE MEMBRANE PROTEIN 16 HUMAN|HGNC=10871|UniProtKB=Q92187 Q92187 ST8SIA4 PTHR11987:SF48 ALPHA-2,8-SIALYLTRANSFERASE CMP-N-ACETYLNEURAMINATE-POLY-ALPHA-2,8-SIALYLTRANSFERASE transferase activity#GO:0016740;catalytic activity#GO:0003824;sialyltransferase activity#GO:0008373;glycosyltransferase activity#GO:0016757 carbohydrate metabolic process#GO:0005975;biosynthetic process#GO:0009058;glycoprotein biosynthetic process#GO:0009101;protein N-linked glycosylation#GO:0006487;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;oligosaccharide metabolic process#GO:0009311;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100 metabolite interconversion enzyme#PC00262;transferase#PC00220 HUMAN|HGNC=15702|UniProtKB=Q8WUA2 Q8WUA2 PPIL4 PTHR45843:SF1 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HUMAN|HGNC=28908|UniProtKB=Q9UKB3 Q9UKB3 DNAJC12 PTHR44500:SF1 DNAJ HOMOLOG SUBFAMILY C MEMBER 12 DNAJ HOMOLOG SUBFAMILY C MEMBER 12 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 chaperone#PC00072 HUMAN|HGNC=2899|UniProtKB=Q9Y238 Q9Y238 DLEC1 PTHR46348:SF1 DELETED IN LUNG AND ESOPHAGEAL CANCER PROTEIN 1 DELETED IN LUNG AND ESOPHAGEAL CANCER PROTEIN 1 tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;protein binding#GO:0005515 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cilium#GO:0005929;cell projection#GO:0042995;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=16137|UniProtKB=Q9BQM9 Q9BQM9 C20orf144 PTHR37335:SF1 RIKEN CDNA 1700003F12 GENE RIKEN CDNA 1700003F12 GENE HUMAN|HGNC=23704|UniProtKB=Q5VTQ0 Q5VTQ0 TTC39B PTHR31859:SF4 TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER TETRATRICOPEPTIDE REPEAT PROTEIN 39B lipid homeostasis#GO:0055088;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;homeostatic process#GO:0042592;biological regulation#GO:0065007;regulation of lipid metabolic process#GO:0019216;negative regulation of cellular process#GO:0048523;chemical homeostasis#GO:0048878;cholesterol homeostasis#GO:0042632;regulation of transport#GO:0051049;regulation of localization#GO:0032879 HUMAN|HGNC=19019|UniProtKB=Q7Z4K8 Q7Z4K8 TRIM46 PTHR24099:SF20 E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED TRIPARTITE MOTIF-CONTAINING PROTEIN 46 plasma membrane bounded cell projection organization#GO:0120036;cell migration#GO:0016477;cytoskeleton-dependent intracellular transport#GO:0030705;multicellular organismal process#GO:0032501;vesicle localization#GO:0051648;axo-dendritic transport#GO:0008088;axon development#GO:0061564;anterograde synaptic vesicle transport#GO:0048490;vesicle cytoskeletal trafficking#GO:0099518;neurogenesis#GO:0022008;neuron migration#GO:0001764;transport along microtubule#GO:0010970;establishment of localization#GO:0051234;cellular developmental process#GO:0048869;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;transport#GO:0006810;vesicle transport along microtubule#GO:0047496;intracellular transport#GO:0046907;microtubule-based movement#GO:0007018;cell motility#GO:0048870;system development#GO:0048731;anterograde axonal transport#GO:0008089;localization#GO:0051179;anatomical structure development#GO:0048856;microtubule cytoskeleton organization#GO:0000226;microtubule bundle formation#GO:0001578;axonal transport#GO:0098930;organelle localization#GO:0051640;cytoskeleton organization#GO:0007010;establishment of vesicle localization#GO:0051650;cell morphogenesis involved in neuron differentiation#GO:0048667;organelle transport along microtubule#GO:0072384;nervous system development#GO:0007399;synaptic vesicle localization#GO:0097479;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;neuron projection development#GO:0031175;organelle organization#GO:0006996;synaptic vesicle transport#GO:0048489;cell projection morphogenesis#GO:0048858;microtubule-based process#GO:0007017;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell development#GO:0048468;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell morphogenesis#GO:0000902;establishment of organelle localization#GO:0051656;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;axonogenesis#GO:0007409;neuron development#GO:0048666;cellular localization#GO:0051641;generation of neurons#GO:0048699;microtubule-based transport#GO:0099111;animal gross anatomical part developmental process#GO:0160108 plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;main axon#GO:0044304;neuron projection#GO:0043005;axon#GO:0030424 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=14687|UniProtKB=Q9Y5Y7 Q9Y5Y7 LYVE1 PTHR10225:SF2 HYALURONAN RECEPTOR LYMPHATIC VESSEL ENDOTHELIAL HYALURONIC ACID RECEPTOR 1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;organic acid binding#GO:0043177;anion binding#GO:0043168;small molecule binding#GO:0036094;binding#GO:0005488;carboxylic acid binding#GO:0031406;ion binding#GO:0043167 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=736|UniProtKB=Q02083 Q02083 NAAA PTHR28583:SF4 ACID AMIDASE N-ACYLETHANOLAMINE-HYDROLYZING ACID AMIDASE hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity#GO:0016787;catalytic activity#GO:0003824 cysteine protease#PC00081 HUMAN|HGNC=28450|UniProtKB=Q8NC44 Q8NC44 RETREG2 PTHR20952:SF4 ADP-RIBOSYLATION-LIKE FACTOR 6-INTERACTING PROTEIN RETICULOPHAGY REGULATOR 2 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 process utilizing autophagic mechanism#GO:0061919;cellular component organization#GO:0016043;endoplasmic reticulum organization#GO:0007029;catabolic process#GO:0009056;endoplasmic reticulum tubular network organization#GO:0071786;metabolic process#GO:0008152;endoplasmic reticulum membrane organization#GO:0090158;cellular component organization or biogenesis#GO:0071840;reticulophagy#GO:0061709;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;autophagy#GO:0006914;cellular component assembly#GO:0022607;macroautophagy#GO:0016236;endomembrane system organization#GO:0010256;membrane organization#GO:0061024 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endoplasmic reticulum tubular network#GO:0071782;membrane#GO:0016020;cytoplasm#GO:0005737;endomembrane system#GO:0012505;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090 HUMAN|HGNC=9781|UniProtKB=P20338 P20338 RAB4A PTHR47979:SF73 DRAB11-RELATED RAS-RELATED PROTEIN RAB-4A nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;GTPase activity#GO:0003924;ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;guanyl nucleotide binding#GO:0019001;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488 regulation of endocytosis#GO:0030100;transport#GO:0006810;regulation of localization#GO:0032879;regulation of transport#GO:0051049;localization#GO:0051179;establishment of localization#GO:0051234;regulation of biological process#GO:0050789;cellular process#GO:0009987;biological regulation#GO:0065007;regulation of cellular component organization#GO:0051128;vesicle-mediated transport#GO:0016192;regulation of cellular process#GO:0050794 cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;intracellular organelle#GO:0043229;recycling endosome#GO:0055037;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;secretory vesicle#GO:0099503;intracellular vesicle#GO:0097708 small GTPase#PC00208;G-protein#PC00020 HUMAN|HGNC=11210|UniProtKB=Q15506 Q15506 SPA17 PTHR10699:SF16 NEUROMODULIN SPERM SURFACE PROTEIN SP17 calmodulin binding#GO:0005516;binding#GO:0005488;protein binding#GO:0005515 9+2 motile cilium#GO:0097729;cilium#GO:0005929;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;sperm principal piece#GO:0097228;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;motile cilium#GO:0031514;organelle#GO:0043226;cellular anatomical structure#GO:0110165;sperm flagellum#GO:0036126 HUMAN|HGNC=2218|UniProtKB=Q14055 Q14055 COL9A2 PTHR24023:SF906 COLLAGEN ALPHA COLLAGEN ALPHA-2(IX) CHAIN structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 external encapsulating structure organization#GO:0045229;cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;cellular process#GO:0009987;extracellular structure organization#GO:0043062;cellular component organization#GO:0016043 cellular anatomical structure#GO:0110165;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576 extracellular matrix structural protein#PC00103;extracellular matrix protein#PC00102 Integrin signalling pathway#P00034>Collagen#P00922 HUMAN|HGNC=9718|UniProtKB=P49023 P49023 PXN PTHR24216:SF11 PAXILLIN-RELATED PAXILLIN molecular sequestering activity#GO:0140313;protein sequestering activity#GO:0140311 cellular response to growth factor stimulus#GO:0071363;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cell-substrate adhesion#GO:0031589;response to transforming growth factor beta#GO:0071559;cell adhesion#GO:0007155;signaling#GO:0023052;cell motility#GO:0048870;regulation of cellular process#GO:0050794;cellular response to endogenous stimulus#GO:0071495;response to growth factor#GO:0070848;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular response to transforming growth factor beta stimulus#GO:0071560;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;cell surface receptor signaling pathway#GO:0007166;substrate adhesion-dependent cell spreading#GO:0034446;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;biological regulation#GO:0065007;cell migration#GO:0016477;endothelial cell migration#GO:0043542;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;cellular process#GO:0009987;signal transduction#GO:0007165;transforming growth factor beta receptor signaling pathway#GO:0007179 cell junction#GO:0030054;cellular anatomical structure#GO:0110165;cell-substrate junction#GO:0030055;focal adhesion#GO:0005925;anchoring junction#GO:0070161;cell-cell junction#GO:0005911 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 Integrin signalling pathway#P00034>Paxillin#P00950;Gonadotropin-releasing hormone receptor pathway#P06664>Paxillin#P06784;CCKR signaling map#P06959>Paxillin#P07145;Angiogenesis#P00005>Paxillin#P00194;VEGF signaling pathway#P00056>Paxillin#P01418 HUMAN|HGNC=18161|UniProtKB=Q96I15 Q96I15 SCLY PTHR11601:SF62 CYSTEINE DESULFURYLASE FAMILY MEMBER SELENOCYSTEINE LYASE lyase#PC00144;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=2624|UniProtKB=A0A087X1C5 A0A087X1C5 CYP2D7 PTHR24300:SF1 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 2D6-RELATED heme binding#GO:0020037;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;monooxygenase activity#GO:0004497;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen#GO:0016712;oxidoreductase activity#GO:0016491;binding#GO:0005488;tetrapyrrole binding#GO:0046906 lipid metabolic process#GO:0006629;unsaturated fatty acid metabolic process#GO:0033559;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;cellular process#GO:0009987;long-chain fatty acid metabolic process#GO:0001676;cellular response to xenobiotic stimulus#GO:0071466;icosanoid metabolic process#GO:0006690;response to chemical#GO:0042221;olefinic compound metabolic process#GO:0120254;cellular response to chemical stimulus#GO:0070887;oxoacid metabolic process#GO:0043436;response to xenobiotic stimulus#GO:0009410;cellular response to stimulus#GO:0051716;arachidonate metabolic process#GO:0019369;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;xenobiotic metabolic process#GO:0006805;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 oxygenase#PC00177;oxidoreductase#PC00176 HUMAN|HGNC=20491|UniProtKB=Q8N9Y4 Q8N9Y4 FAM181A PTHR33766:SF1 PROTEIN FAM181B PROTEIN FAM181A HUMAN|HGNC=32284|UniProtKB=P0CI00 P0CI00 ZNF705B PTHR24381:SF303 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 705A-RELATED DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=6629|UniProtKB=Q6P1M3 Q6P1M3 LLGL2 PTHR10241:SF20 LETHAL 2 GIANT LARVAE PROTEIN LLGL SCRIBBLE CELL POLARITY COMPLEX COMPONENT 2 binding#GO:0005488;syntaxin binding#GO:0019905;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;myosin binding#GO:0017022;enzyme activator activity#GO:0008047;SNARE binding#GO:0000149;molecular function regulator activity#GO:0098772;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695 cytoskeleton organization#GO:0007010;regulation of establishment or maintenance of cell polarity#GO:0032878;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;organelle organization#GO:0006996;microtubule-based process#GO:0007017;establishment of spindle orientation#GO:0051294;exocytosis#GO:0006887;cellular component organization or biogenesis#GO:0071840;Golgi vesicle transport#GO:0048193;export from cell#GO:0140352;establishment of organelle localization#GO:0051656;cell cycle process#GO:0022402;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;secretion by cell#GO:0032940;post-Golgi vesicle-mediated transport#GO:0006892;cellular localization#GO:0051641;spindle localization#GO:0051653;regulation of signaling#GO:0023051;establishment or maintenance of cell polarity#GO:0007163;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;establishment of spindle localization#GO:0051293;vesicle-mediated transport to the plasma membrane#GO:0098876;establishment of localization#GO:0051234;regulation of response to stimulus#GO:0048583;transport#GO:0006810;regulation of cell communication#GO:0010646;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;Golgi to plasma membrane transport#GO:0006893;establishment of cell polarity#GO:0030010;cell cycle#GO:0007049;microtubule cytoskeleton organization#GO:0000226;secretion#GO:0046903;cortical actin cytoskeleton organization#GO:0030866;localization#GO:0051179;regulation of Notch signaling pathway#GO:0008593;actin filament-based process#GO:0030029;localization within membrane#GO:0051668;cortical cytoskeleton organization#GO:0030865;organelle localization#GO:0051640 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;cell periphery#GO:0071944;cell cortex#GO:0005938;membrane#GO:0016020;cortical cytoskeleton#GO:0030863;actin cytoskeleton#GO:0015629;cytoplasm#GO:0005737;cortical actin cytoskeleton#GO:0030864;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226 membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=28218|UniProtKB=Q9BRA2 Q9BRA2 TXNDC17 PTHR12452:SF7 42-9-9 PROTEIN-RELATED THIOREDOXIN DOMAIN-CONTAINING PROTEIN 17 oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;catalytic activity#GO:0003824;disulfide oxidoreductase activity#GO:0015036;protein-disulfide reductase activity#GO:0015035;oxidoreductase activity#GO:0016491;catalytic activity, acting on a protein#GO:0140096 regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;cytokine-mediated signaling pathway#GO:0019221;cell communication#GO:0007154;tumor necrosis factor-mediated signaling pathway#GO:0033209;response to peptide#GO:1901652;response to tumor necrosis factor#GO:0034612;signal transduction#GO:0007165;cellular process#GO:0009987;response to chemical#GO:0042221;response to cytokine#GO:0034097;biological regulation#GO:0065007;cell surface receptor signaling pathway#GO:0007166 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 transporter#PC00227 HUMAN|HGNC=21536|UniProtKB=A6NNA5 A6NNA5 DRGX PTHR24329:SF542 HOMEOBOX PROTEIN ARISTALESS DORSAL ROOT GANGLIA HOMEOBOX PROTEIN double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;nervous system development#GO:0007399;developmental process#GO:0032502;neuron differentiation#GO:0030182;multicellular organism development#GO:0007275;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;cell development#GO:0048468;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;system development#GO:0048731;neuron development#GO:0048666;regulation of RNA metabolic process#GO:0051252 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=12709|UniProtKB=P12018 P12018 VPREB1 PTHR23267:SF11 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN IOTA CHAIN response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=31111|UniProtKB=A6NH57 A6NH57 ARL5C PTHR11711:SF148 ADP RIBOSYLATION FACTOR-RELATED ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 5C-RELATED GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;guanyl nucleotide binding#GO:0019001;anion binding#GO:0043168;binding#GO:0005488;small molecule binding#GO:0036094;nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167;nucleotide binding#GO:0000166;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;ribonucleotide binding#GO:0032553;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;carbohydrate derivative binding#GO:0097367 macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;protein localization to Golgi apparatus#GO:0034067;intracellular protein transport#GO:0006886;transport#GO:0006810;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;protein localization to membrane#GO:0072657;protein localization to organelle#GO:0033365;localization within membrane#GO:0051668;cellular localization#GO:0051641;localization#GO:0051179;protein transport#GO:0015031 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;Golgi apparatus subcompartment#GO:0098791;trans-Golgi network#GO:0005802;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 G-protein#PC00020 HUMAN|HGNC=6219|UniProtKB=Q16322 Q16322 KCNA10 PTHR11537:SF44 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 10 voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;potassium channel activity#GO:0005267 establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;transport#GO:0006810;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813;cellular process#GO:0009987;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;metal ion transport#GO:0030001;action potential#GO:0001508 plasma membrane#GO:0005886;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane#GO:0016020;membrane protein complex#GO:0098796;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703 ion channel#PC00133;voltage-gated ion channel#PC00241 HUMAN|HGNC=3488|UniProtKB=P14921 P14921 ETS1 PTHR11849:SF314 ETS PROTEIN C-ETS-1 transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;developmental process#GO:0032502;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 DNA-binding transcription factor#PC00218;winged helix/forkhead transcription factor#PC00246 Angiogenesis#P00005>Ets#P00188;Ras Pathway#P04393>Ets#P04563;PDGF signaling pathway#P00047>Ets#P01167;VEGF signaling pathway#P00056>Ets#P01419 HUMAN|HGNC=2309|UniProtKB=O14810 O14810 CPLX1 PTHR16705:SF6 COMPLEXIN COMPLEXIN-1 binding#GO:0005488;SNARE binding#GO:0000149;protein binding#GO:0005515 cellular localization#GO:0051641;secretion by cell#GO:0032940;regulation of signaling#GO:0023051;regulation of cellular component organization#GO:0051128;signaling#GO:0023052;export from cell#GO:0140352;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;vesicle-mediated transport in synapse#GO:0099003;exocytosis#GO:0006887;regulation of transport#GO:0051049;regulation of localization#GO:0032879;regulated exocytosis#GO:0045055;vesicle-mediated transport#GO:0016192;regulation of trans-synaptic signaling#GO:0099177;neurotransmitter transport#GO:0006836;synaptic signaling#GO:0099536;cellular process#GO:0009987;synaptic vesicle exocytosis#GO:0016079;establishment of localization in cell#GO:0051649;secretion#GO:0046903;cell communication#GO:0007154;localization#GO:0051179;trans-synaptic signaling#GO:0099537;signal release#GO:0023061;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;regulation of cell communication#GO:0010646;modulation of chemical synaptic transmission#GO:0050804;signal release from synapse#GO:0099643;chemical synaptic transmission#GO:0007268;establishment of localization#GO:0051234;synaptic vesicle cycle#GO:0099504;transport#GO:0006810;neurotransmitter secretion#GO:0007269;biological regulation#GO:0065007;cell-cell signaling#GO:0007267 presynapse#GO:0098793;neuron projection#GO:0043005;membrane#GO:0016020;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;axon terminus#GO:0043679;cell junction#GO:0030054;membrane protein complex#GO:0098796;neuron projection terminus#GO:0044306;cell projection#GO:0042995;distal axon#GO:0150034;terminal bouton#GO:0043195;plasma membrane bounded cell projection#GO:0120025;SNARE complex#GO:0031201;synapse#GO:0045202;cellular anatomical structure#GO:0110165;axon#GO:0030424;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=30779|UniProtKB=Q49AM1 Q49AM1 MTERF2 PTHR15437:SF1 TRANSCRIPTION TERMINATION FACTOR, MITOCHONDRIAL TRANSCRIPTION TERMINATION FACTOR 2, MITOCHONDRIAL DNA binding#GO:0003677;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;sequence-specific DNA binding#GO:0043565;binding#GO:0005488;nucleic acid binding#GO:0003676 metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;DNA-templated transcription termination#GO:0006353;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;mitochondrial transcription#GO:0006390;nucleic acid biosynthetic process#GO:0141187;mitochondrial RNA metabolic process#GO:0000959;RNA metabolic process#GO:0016070;mitochondrial gene expression#GO:0140053;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 General transcription regulation#P00023>TTF2#P00661;Transcription regulation by bZIP transcription factor#P00055>TTF2#P01389 HUMAN|HGNC=8508|UniProtKB=O95747 O95747 OXSR1 PTHR48012:SF1 STERILE20-LIKE KINASE, ISOFORM B-RELATED SERINE_THREONINE-PROTEIN KINASE OSR1 protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740 positive regulation of response to stimulus#GO:0048584;regulation of locomotion#GO:0040012;biological regulation#GO:0065007;positive regulation of cell migration#GO:0030335;positive regulation of cellular process#GO:0048522;positive regulation of locomotion#GO:0040017;regulation of response to stimulus#GO:0048583;regulation of cell migration#GO:0030334;response to osmotic stress#GO:0006970;regulation of cellular process#GO:0050794;cellular response to environmental stimulus#GO:0104004;regulation of immune system process#GO:0002682;regulation of leukocyte migration#GO:0002685;hyperosmotic response#GO:0006972;cellular response to stimulus#GO:0051716;positive regulation of chemotaxis#GO:0050921;regulation of cell motility#GO:2000145;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular response to osmotic stress#GO:0071470;regulation of lymphocyte migration#GO:2000401;regulation of response to external stimulus#GO:0032101;response to chemical#GO:0042221;response to stress#GO:0006950;positive regulation of immune system process#GO:0002684;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular response to abiotic stimulus#GO:0071214;positive regulation of response to external stimulus#GO:0032103;cellular response to chemical stress#GO:0062197;response to stimulus#GO:0050896;signaling#GO:0023052;response to abiotic stimulus#GO:0009628;regulation of chemotaxis#GO:0050920;positive regulation of cell motility#GO:2000147;regulation of biological process#GO:0050789;cellular response to chemical stimulus#GO:0070887;cellular response to stress#GO:0033554 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=1094|UniProtKB=Q86WA6 Q86WA6 BPHL PTHR46331:SF2 VALACYCLOVIR HYDROLASE SERINE HYDROLASE BPHL catalytic activity#GO:0003824;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HUMAN|HGNC=4398|UniProtKB=P62879 P62879 GNB2 PTHR19850:SF27 GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)_G(S)_G(T) SUBUNIT BETA-2 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;signaling receptor complex adaptor activity#GO:0030159;signaling adaptor activity#GO:0035591 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 membrane protein complex#GO:0098796;cytoplasmic side of plasma membrane#GO:0009898;plasma membrane protein complex#GO:0098797;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494;extrinsic component of cytoplasmic side of plasma membrane#GO:0031234;side of membrane#GO:0098552;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;cell periphery#GO:0071944;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;cytoplasm#GO:0005737;cytoplasmic side of membrane#GO:0098562;extrinsic component of membrane#GO:0019898;extrinsic component of plasma membrane#GO:0019897 heterotrimeric G-protein#PC00117;G-protein#PC00020;protein-binding activity modulator#PC00095 Beta3 adrenergic receptor signaling pathway#P04379>G-Protein#P04448;Opioid prodynorphin pathway#P05916>G-protein#P06002;Beta1 adrenergic receptor signaling pathway#P04377>G-Protein#P04436;Wnt signaling pathway#P00057>GBeta#P01457;Metabotropic glutamate receptor group II pathway#P00040>G-protein#P01047;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GIRK#P00743;Histamine H2 receptor mediated signaling pathway#P04386>G-Protein#P04490;Beta2 adrenergic receptor signaling pathway#P04378>G-Protein#P04443;Dopamine receptor mediated signaling pathway#P05912>Gbeta#P05954;Histamine H1 receptor mediated signaling pathway#P04385>G-Protein#P04488;Opioid proenkephalin pathway#P05915>G-protein#P05994;5HT1 type receptor mediated signaling pathway#P04373>G-protein#P04408;PI3 kinase pathway#P00048>Gbetagamma#P01188;Endogenous cannabinoid signaling#P05730>Gbeta#P05745;Thyrotropin-releasing hormone receptor signaling pathway#P04394>G-Protein#P04584;5HT2 type receptor mediated signaling pathway#P04374>G-protein#P04416;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Gbeta#P00710;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Gbeta#P00753;Enkephalin release#P05913>G-Protein (i)#P05974;GABA-B receptor II signaling#P05731>Gbeta#P05755;Enkephalin release#P05913>G-Protein (s)#P05977;Gonadotropin-releasing hormone receptor pathway#P06664>Gbeta#P06769;Metabotropic glutamate receptor group III pathway#P00039>G-Protein#P01045;5HT4 type receptor mediated signaling pathway#P04376>G-protein#P04430;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>G-Protein#P01073;Opioid proopiomelanocortin pathway#P05917>G-protein#P06012;Angiotensin II-stimulated signaling through G proteins and beta-arrestin#P05911>Gbeta#P05930;Oxytocin receptor mediated signaling pathway#P04391>G-Protein#P04534;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Gbeta#P00727;Cortocotropin releasing factor receptor signaling pathway#P04380>G-Protein#P04458;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>G-Protein#P01085 HUMAN|HGNC=3151|UniProtKB=P30084 P30084 ECHS1 PTHR11941:SF179 ENOYL-COA HYDRATASE-RELATED ENOYL-COA HYDRATASE, MITOCHONDRIAL monocarboxylic acid catabolic process#GO:0072329;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;lipid catabolic process#GO:0016042;lipid modification#GO:0030258;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;fatty acid beta-oxidation#GO:0006635;fatty acid oxidation#GO:0019395;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;small molecule catabolic process#GO:0044282;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;monocarboxylic acid metabolic process#GO:0032787;lipid oxidation#GO:0034440;fatty acid catabolic process#GO:0009062;oxoacid metabolic process#GO:0043436 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 lyase#PC00144;hydratase#PC00120;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=11538|UniProtKB=Q92750 Q92750 TAF4B PTHR15138:SF17 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4B DNA binding#GO:0003677;binding#GO:0005488;nucleic acid binding#GO:0003676 DNA-templated transcription initiation#GO:0006352;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;transcription initiation at RNA polymerase II promoter#GO:0006367;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;transcription by RNA polymerase II#GO:0006366 transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;RNA polymerase II, holoenzyme#GO:0016591;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;transcription regulator complex#GO:0005667;membrane-enclosed lumen#GO:0031974;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;transcription factor TFIID complex#GO:0005669 general transcription factor#PC00259 HUMAN|HGNC=25005|UniProtKB=Q9P031 Q9P031 CCDC59 PTHR15657:SF1 THYROID TRANSCRIPTION FACTOR 1-ASSOCIATED PROTEIN 26 THYROID TRANSCRIPTION FACTOR 1-ASSOCIATED PROTEIN 26 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=19018|UniProtKB=Q9H8W5 Q9H8W5 TRIM45 PTHR25462:SF291 BONUS, ISOFORM C-RELATED E3 UBIQUITIN-PROTEIN LIGASE TRIM45 ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=52292|UniProtKB=A0A0K2S4Q6 A0A0K2S4Q6 CD300H PTHR11860:SF117 POLYMERIC-IMMUNOGLOBULIN RECEPTOR PROTEIN CD300H molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 regulation of response to external stimulus#GO:0032101;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of innate immune response#GO:0045088;regulation of response to stress#GO:0080134;regulation of response to stimulus#GO:0048583;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;response to stimulus#GO:0050896;regulation of response to biotic stimulus#GO:0002831;signaling#GO:0023052;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cell communication#GO:0007154;regulation of defense response#GO:0031347;regulation of immune response#GO:0050776 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=7965|UniProtKB=P55055 P55055 NR1H2 PTHR24082:SF316 NUCLEAR HORMONE RECEPTOR OXYSTEROLS RECEPTOR LXR-BETA RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;molecular transducer activity#GO:0060089;DNA binding#GO:0003677;nuclear receptor activity#GO:0004879;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulator activity#GO:0140110;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023 regulation of inflammatory response#GO:0050727;regulation of defense response#GO:0031347;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;positive regulation of RNA metabolic process#GO:0051254;homeostatic process#GO:0042592;negative regulation of defense response#GO:0031348;negative regulation of inflammatory response#GO:0050728;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of response to stimulus#GO:0048583;developmental process#GO:0032502;regulation of response to stress#GO:0080134;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;cholesterol homeostasis#GO:0042632;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;positive regulation of RNA biosynthetic process#GO:1902680;negative regulation of response to stimulus#GO:0048585;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of biological process#GO:0050789;lipid homeostasis#GO:0055088;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of RNA metabolic process#GO:0051253;chemical homeostasis#GO:0048878;negative regulation of RNA biosynthetic process#GO:1902679;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of transport#GO:0051049;regulation of localization#GO:0032879;cellular process#GO:0009987;positive regulation of transport#GO:0051050;positive regulation of biological process#GO:0048518;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of response to external stimulus#GO:0032102;regulation of response to external stimulus#GO:0032101;positive regulation of macromolecule metabolic process#GO:0010604 nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;nuclear protein-containing complex#GO:0140513 C4 zinc finger nuclear receptor#PC00169 HUMAN|HGNC=29424|UniProtKB=Q8TF21 Q8TF21 ANKRD24 PTHR24173:SF16 ANKYRIN REPEAT CONTAINING ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 24 sensory perception of mechanical stimulus#GO:0050954;sensory perception#GO:0007600;nervous system process#GO:0050877;sensory perception of sound#GO:0007605;multicellular organismal process#GO:0032501;system process#GO:0003008 scaffold/adaptor protein#PC00226 HUMAN|HGNC=20302|UniProtKB=Q86VW1 Q86VW1 SLC22A16 PTHR24064:SF186 SOLUTE CARRIER FAMILY 22 MEMBER SOLUTE CARRIER FAMILY 22 MEMBER 16 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;quaternary ammonium group transmembrane transporter activity#GO:0015651 localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;quaternary ammonium group transport#GO:0015697;nitrogen compound transport#GO:0071705;transport#GO:0006810;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258 HUMAN|HGNC=11551|UniProtKB=Q92994 Q92994 BRF1 PTHR11618:SF4 TRANSCRIPTION INITIATION FACTOR IIB-RELATED TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;transcription by RNA polymerase III#GO:0006383;DNA-templated transcription initiation#GO:0006352;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774 intracellular organelle#GO:0043229;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;protein-DNA complex#GO:0032993;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 general transcription factor#PC00259 Transcription regulation by bZIP transcription factor#P00055>TFIIB#P01397;General transcription regulation#P00023>TFIIB#P00668 HUMAN|HGNC=17886|UniProtKB=O75526 O75526 RBMXL2 PTHR13952:SF11 U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KD RNA-BINDING MOTIF PROTEIN, X-LINKED-LIKE-2 snRNA binding#GO:0017069;RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170 spliceosomal complex#GO:0005681;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;precatalytic spliceosome#GO:0071011;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148 HUMAN|HGNC=17916|UniProtKB=Q8WTX9 Q8WTX9 ZDHHC1 PTHR22883:SF8 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE ZDHHC1 acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;palmitoyltransferase activity#GO:0016409;catalytic activity, acting on a protein#GO:0140096;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740 response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;protein targeting#GO:0006605;response to stimulus#GO:0050896;antiviral innate immune response#GO:0140374;defense response to virus#GO:0051607;response to virus#GO:0009615;cellular localization#GO:0051641;localization#GO:0051179;localization within membrane#GO:0051668;immune system process#GO:0002376;response to other organism#GO:0051707;defense response to other organism#GO:0098542;cellular process#GO:0009987;defense response to symbiont#GO:0140546;immune response#GO:0006955;establishment of protein localization#GO:0045184;response to stress#GO:0006950;establishment of protein localization to membrane#GO:0090150;response to biotic stimulus#GO:0009607;defense response#GO:0006952;response to external stimulus#GO:0009605;establishment of localization#GO:0051234;innate immune response#GO:0045087;protein targeting to membrane#GO:0006612 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 protein modifying enzyme#PC00260 HUMAN|HGNC=12962|UniProtKB=Q12899 Q12899 TRIM26 PTHR24103:SF369 E3 UBIQUITIN-PROTEIN LIGASE TRIM TRIPARTITE MOTIF-CONTAINING PROTEIN 26 ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740 response to biotic stimulus#GO:0009607;response to stress#GO:0006950;immune response#GO:0006955;defense response to symbiont#GO:0140546;response to stimulus#GO:0050896;defense response to other organism#GO:0098542;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to other organism#GO:0051707;immune system process#GO:0002376;innate immune response#GO:0045087;response to external stimulus#GO:0009605;defense response#GO:0006952 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=6843|UniProtKB=P46734 P46734 MAP2K3 PTHR48013:SF21 DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3 phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;protein kinase activity#GO:0004672;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 MAPK cascade#GO:0000165;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;intracellular signaling cassette#GO:0141124 non-receptor serine/threonine protein kinase#PC00167 Toll receptor signaling pathway#P00054>MKK3#P01367;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>MEK#P00891;Apoptosis signaling pathway#P00006>MKK3#P00314;EGF receptor signaling pathway#P00018>MKK3,6#P00540;Integrin signalling pathway#P00034>MEK#P00925;Ras Pathway#P04393>MKK3/6#P04568;FGF signaling pathway#P00021>MKK3,6#P00625;Gonadotropin-releasing hormone receptor pathway#P06664>MKK3/6#P06805;p38 MAPK pathway#P05918>MKK3#P06036;Oxidative stress response#P00046>MKK3/6#P01121 HUMAN|HGNC=30888|UniProtKB=Q96DN5 Q96DN5 TBC1D31 PTHR19853:SF1 WD REPEAT CONTAINING PROTEIN 3 WDR3 TBC1 DOMAIN FAMILY MEMBER 31 plasma membrane bounded cell projection assembly#GO:0120031;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cell projection assembly#GO:0030031;cell projection organization#GO:0030030;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytoskeleton#GO:0005856;ciliary basal body#GO:0036064;microtubule organizing center#GO:0005815;cilium#GO:0005929;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;microtubule cytoskeleton#GO:0015630 HUMAN|HGNC=16963|UniProtKB=Q7L523 Q7L523 RRAGA PTHR11259:SF7 RAS-RELATED GTP BINDING RAG/GTR YEAST RAS-RELATED GTP-BINDING PROTEIN A anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167;GTPase activity#GO:0003924;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleotide binding#GO:0000166;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;nucleoside phosphate binding#GO:1901265;guanyl nucleotide binding#GO:0019001;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;hydrolase activity, acting on acid anhydrides#GO:0016817;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363 positive regulation of cellular process#GO:0048522;response to nutrient levels#GO:0031667;regulation of metabolic process#GO:0019222;positive regulation of TORC1 signaling#GO:1904263;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of response to stimulus#GO:0048584;cellular response to nutrient levels#GO:0031669;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;cellular response to starvation#GO:0009267;negative regulation of cellular process#GO:0048523;negative regulation of autophagy#GO:0010507;regulation of TORC1 signaling#GO:1903432;regulation of catabolic process#GO:0009894;cellular response to stimulus#GO:0051716;response to starvation#GO:0042594;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;negative regulation of catabolic process#GO:0009895;positive regulation of TOR signaling#GO:0032008;positive regulation of biological process#GO:0048518;regulation of TOR signaling#GO:0032006;cellular process#GO:0009987;response to stress#GO:0006950;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of autophagy#GO:0010506;negative regulation of metabolic process#GO:0009892;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;positive regulation of signaling#GO:0023056 lytic vacuole#GO:0000323;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;vacuole#GO:0005773;lysosome#GO:0005764;nucleus#GO:0005634 small GTPase#PC00208 HUMAN|HGNC=15791|UniProtKB=Q9H490 Q9H490 PIGU PTHR13121:SF0 GPI TRANSAMIDASE COMPONENT PIG-U GPI-ANCHOR TRANSAMIDASE COMPONENT PIGU macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;GPI anchored protein biosynthesis#GO:0180046;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 membrane#GO:0016020;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;peptidase complex#GO:1905368;cytoplasm#GO:0005737;caspase complex#GO:0008303;endoplasmic reticulum membrane#GO:0005789;endopeptidase complex#GO:1905369;transferase complex#GO:1990234;endoplasmic reticulum#GO:0005783;endoplasmic reticulum protein-containing complex#GO:0140534;organelle membrane#GO:0031090;membrane protein complex#GO:0098796;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=9339|UniProtKB=Q04118 Q04118 PRB3 PTHR23203:SF4 PROLINE-RICH PROTEIN BASIC SALIVARY PROLINE-RICH PROTEIN 3 antimicrobial response protein#PC00051 HUMAN|HGNC=8498|UniProtKB=P02763 P02763 ORM1 PTHR11967:SF2 ALPHA-1-ACID GLYCOPROTEIN ALPHA-1-ACID GLYCOPROTEIN 1 inflammatory response#GO:0006954;immune response#GO:0006955;immune system process#GO:0002376;response to stress#GO:0006950;acute inflammatory response#GO:0002526;defense response#GO:0006952;response to stimulus#GO:0050896 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=34006|UniProtKB=Q6ZWE6 Q6ZWE6 PLEKHM3 PTHR12326:SF10 PLECKSTRIN HOMOLOGY DOMAIN CONTAINING PROTEIN PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY M MEMBER 3 HUMAN|HGNC=12441|UniProtKB=P04818 P04818 TYMS PTHR11548:SF2 THYMIDYLATE SYNTHASE 1 THYMIDYLATE SYNTHASE transferase activity, transferring one-carbon groups#GO:0016741;methyltransferase activity#GO:0008168;transferase activity#GO:0016740;catalytic activity#GO:0003824 small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;nucleoside monophosphate metabolic process#GO:0009123;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;organophosphate biosynthetic process#GO:0090407;nucleotide metabolic process#GO:0009117;nucleotide biosynthetic process#GO:0009165;nucleoside monophosphate biosynthetic process#GO:0009124;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;organophosphate metabolic process#GO:0019637;pyrimidine-containing compound metabolic process#GO:0072527;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;carbohydrate derivative biosynthetic process#GO:1901137;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing small molecule metabolic process#GO:0055086;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cytosol#GO:0005829;mitochondrion#GO:0005739 metabolite interconversion enzyme#PC00262;methyltransferase#PC00155;transferase#PC00220 Formyltetrahydrofolate biosynthesis#P02743>Thymidylate synthase#P02954;Tetrahydrofolate biosynthesis#P02742>Dihydrofolate synthase#P02943;De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>Thymidylate synthase#P02913;Tetrahydrofolate biosynthesis#P02742>Dihydrofolate reductase#P02948;Formyltetrahydrofolate biosynthesis#P02743>Dihydrofolate reductase#P02957 HUMAN|HGNC=21033|UniProtKB=Q8IYU2 Q8IYU2 HACE1 PTHR11254:SF363 HECT DOMAIN UBIQUITIN-PROTEIN LIGASE E3 UBIQUITIN-PROTEIN LIGASE HACE1 aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746 cellular process#GO:0009987;membrane fusion#GO:0061025;organelle organization#GO:0006996;membrane organization#GO:0061024;endomembrane system organization#GO:0010256;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;modification-dependent protein catabolic process#GO:0019941;Golgi organization#GO:0007030;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;catabolic process#GO:0009056;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538 Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane#GO:0016020;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=33628|UniProtKB=A6NLJ0 A6NLJ0 C2CD4B PTHR47226:SF1 C2 CALCIUM-DEPENDENT DOMAIN-CONTAINING PROTEIN 4A C2 CALCIUM-DEPENDENT DOMAIN-CONTAINING PROTEIN 4B circulatory system process#GO:0003013;inflammatory response#GO:0006954;acute inflammatory response#GO:0002526;system process#GO:0003008;regulation of biological quality#GO:0065008;defense response#GO:0006952;response to stress#GO:0006950;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;blood circulation#GO:0008015;regulation of cellular process#GO:0050794;multicellular organismal process#GO:0032501;regulation of cell adhesion#GO:0030155;biological regulation#GO:0065007 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=33894|UniProtKB=B2RU33 B2RU33 POTEC PTHR24118:SF65 POTE ANKYRIN DOMAIN POTE ANKYRIN DOMAIN FAMILY MEMBER B-RELATED transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714;transcription regulator activity#GO:0140110 regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;regulation of intracellular signal transduction#GO:1902531;regulation of biological process#GO:0050789;regulation of non-canonical NF-kappaB signal transduction#GO:1901222;regulation of cell communication#GO:0010646;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cellular process#GO:0050794 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;intracellular organelle#GO:0043229 membrane traffic protein#PC00150 HUMAN|HGNC=24166|UniProtKB=Q96KN1 Q96KN1 LRATD2 PTHR46341:SF2 PROTEIN FAM84B-RELATED PROTEIN LRATD2 HUMAN|HGNC=13160|UniProtKB=Q03923 Q03923 ZNF85 PTHR24384:SF211 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED ZINC FINGER PROTEIN 138-RELATED sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 DNA-binding transcription factor#PC00218 HUMAN|HGNC=3393|UniProtKB=P29323 P29323 EPHB2 PTHR46877:SF11 EPH RECEPTOR A5 EPHRIN TYPE-B RECEPTOR 2 catalytic activity, acting on a protein#GO:0140096;signaling receptor activity#GO:0038023;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein tyrosine kinase activity#GO:0004713;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773;molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888 axonogenesis#GO:0007409;neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;cell differentiation#GO:0030154;cell projection organization#GO:0030030;response to stimulus#GO:0050896;cell morphogenesis#GO:0000902;signaling#GO:0023052;cell development#GO:0048468;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cell projection morphogenesis#GO:0048858;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell surface receptor signaling pathway#GO:0007166;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;neuron projection development#GO:0031175;signal transduction#GO:0007165;cellular process#GO:0009987;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;system development#GO:0048731;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of cellular process#GO:0050794;ephrin receptor signaling pathway#GO:0048013;cellular response to stimulus#GO:0051716;cellular developmental process#GO:0048869;neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;axon development#GO:0061564;axon guidance#GO:0007411 dendrite#GO:0030425;dendritic tree#GO:0097447;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025 transmembrane signal receptor#PC00197 PDGF signaling pathway#P00047>PDGF receptor B#P01156;Angiogenesis#P00005>EphR#P00212 HUMAN|HGNC=15765|UniProtKB=O95396 O95396 MOCS3 PTHR10953:SF254 UBIQUITIN-ACTIVATING ENZYME E1 ADENYLYLTRANSFERASE AND SULFURTRANSFERASE MOCS3 thiosulfate-cyanide sulfurtransferase activity#GO:0004792;sulfurtransferase activity#GO:0016783;transferase activity, transferring sulphur-containing groups#GO:0016782;ligase activity, forming carbon-sulfur bonds#GO:0016877;ATP-dependent activity#GO:0140657;catalytic activity, acting on a protein#GO:0140096;nucleotidyltransferase activity#GO:0016779;transferase activity#GO:0016740;catalytic activity#GO:0003824;ligase activity#GO:0016874;ubiquitin-like modifier activating enzyme activity#GO:0008641;transferase activity, transferring phosphorus-containing groups#GO:0016772 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;post-translational protein modification#GO:0043687;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;protein modification process#GO:0036211;tRNA wobble uridine modification#GO:0002098;tRNA wobble base modification#GO:0002097;tRNA wobble position uridine thiolation#GO:0002143;protein modification by small protein conjugation#GO:0032446;tRNA modification#GO:0006400;RNA biosynthetic process#GO:0032774;protein modification by small protein conjugation or removal#GO:0070647;RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187;tRNA thio-modification#GO:0034227;protein metabolic process#GO:0019538;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=18356|UniProtKB=Q8TDN7 Q8TDN7 ACER1 PTHR46139:SF2 ALKALINE CERAMIDASE ALKALINE CERAMIDASE 1 hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;catalytic activity#GO:0003824;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811 sphingoid biosynthetic process#GO:0046520;ceramide metabolic process#GO:0006672;primary metabolic process#GO:0044238;sphingolipid catabolic process#GO:0030149;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;sphingolipid biosynthetic process#GO:0030148;alcohol metabolic process#GO:0006066;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;cellular process#GO:0009987;lipid catabolic process#GO:0016042;alcohol biosynthetic process#GO:0046165;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=9688|UniProtKB=Q6NZI2 Q6NZI2 CAVIN1 PTHR15240:SF3 CAVIN CAVEOLAE-ASSOCIATED PROTEIN 1 RNA binding#GO:0003723;rRNA binding#GO:0019843;binding#GO:0005488;nucleic acid binding#GO:0003676 nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;DNA-templated transcription initiation#GO:0006352;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;transcription initiation at RNA polymerase I promoter#GO:0006361;transcription by RNA polymerase I#GO:0006360;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;DNA-templated transcription termination#GO:0006353;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058 intracellular anatomical structure#GO:0005622;plasma membrane raft#GO:0044853;membrane microdomain#GO:0098857;plasma membrane#GO:0005886;cytoplasm#GO:0005737;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;caveola#GO:0005901;membrane raft#GO:0045121 membrane traffic protein#PC00150 General transcription by RNA polymerase I#P00022>PTRF#P00656 HUMAN|HGNC=10495|UniProtKB=P33763 P33763 S100A5 PTHR11639:SF65 S100 CALCIUM-BINDING PROTEIN PROTEIN S100-A5 ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;calcium ion binding#GO:0005509;protein binding#GO:0005515;metal ion binding#GO:0046872;cation binding#GO:0043169 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 calmodulin-related#PC00061;calcium-binding protein#PC00060 HUMAN|HGNC=28037|UniProtKB=Q9P0P0 Q9P0P0 RNF181 PTHR15710:SF243 E3 UBIQUITIN-PROTEIN LIGASE PRAJA E3 UBIQUITIN-PROTEIN LIGASE RNF181 aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746 primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=285|UniProtKB=P08588 P08588 ADRB1 PTHR24248:SF54 ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR BETA-1 ADRENERGIC RECEPTOR signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;G protein-coupled amine receptor activity#GO:0008227;transmembrane signaling receptor activity#GO:0004888 regulation of systemic arterial blood pressure#GO:0003073;regulation of blood pressure#GO:0008217;cellular process#GO:0009987;signal transduction#GO:0007165;multicellular organismal process#GO:0032501;blood circulation#GO:0008015;biological regulation#GO:0065007;regulation of anatomical structure size#GO:0090066;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;system process#GO:0003008;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;vasodilation#GO:0042311;signaling#GO:0023052;circulatory system process#GO:0003013;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;adrenergic receptor signaling pathway#GO:0071875;regulation of biological quality#GO:0065008 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GsPCR#P00720;Beta1 adrenergic receptor signaling pathway#P04377>Beta1#P04433 HUMAN|HGNC=28406|UniProtKB=A8MPX8 A8MPX8 PP2D1 PTHR13832:SF837 PROTEIN PHOSPHATASE 2C PROTEIN PHOSPHATASE 2C-LIKE DOMAIN-CONTAINING PROTEIN 1 catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721 negative regulation of response to stimulus#GO:0048585;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of MAPK cascade#GO:0043408;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of cell communication#GO:0010646;signaling#GO:0023052;negative regulation of biological process#GO:0048519;cellular response to stimulus#GO:0051716;negative regulation of MAPK cascade#GO:0043409;regulation of biological process#GO:0050789;negative regulation of intracellular signal transduction#GO:1902532;cell communication#GO:0007154;negative regulation of cell communication#GO:0010648;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 protein phosphatase#PC00195 HUMAN|HGNC=30396|UniProtKB=Q9BQE4 Q9BQE4 SELENOS PTHR28621:SF1 SELENOPROTEIN S SELENOPROTEIN S response to topologically incorrect protein#GO:0035966;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;protein transport#GO:0015031;response to unfolded protein#GO:0006986;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;proteasomal protein catabolic process#GO:0010498;response to chemical#GO:0042221;cellular process#GO:0009987;signal transduction#GO:0007165;establishment of protein localization#GO:0045184;response to stress#GO:0006950;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;intracellular signal transduction#GO:0035556;ERAD pathway#GO:0036503;protein metabolic process#GO:0019538;cell communication#GO:0007154;localization#GO:0051179;cellular response to topologically incorrect protein#GO:0035967;cellular response to unfolded protein#GO:0034620;response to endoplasmic reticulum stress#GO:0034976;biological regulation#GO:0065007;endoplasmic reticulum unfolded protein response#GO:0030968;macromolecule localization#GO:0033036;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;transport#GO:0006810 membrane#GO:0016020;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum protein-containing complex#GO:0140534;organelle membrane#GO:0031090;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=19340|UniProtKB=P43356 P43356 MAGEA2 PTHR11736:SF74 MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN MELANOMA-ASSOCIATED ANTIGEN 2 protein binding#GO:0005515;histone deacetylase binding#GO:0042826;enzyme binding#GO:0019899;binding#GO:0005488 regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=9386|UniProtKB=Q9UGJ0 Q9UGJ0 PRKAG2 PTHR13780:SF122 AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-2 ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;kinase regulator activity#GO:0019207;protein kinase regulator activity#GO:0019887;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;kinase binding#GO:0019900;protein binding#GO:0005515;enzyme regulator activity#GO:0030234;nucleotide binding#GO:0000166;molecular function regulator activity#GO:0098772;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;cation binding#GO:0043169 cellular response to stress#GO:0033554;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;response to starvation#GO:0042594;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of carbohydrate biosynthetic process#GO:0043255;regulation of carbohydrate metabolic process#GO:0006109;cellular response to starvation#GO:0009267;cellular response to nutrient levels#GO:0031669;regulation of biosynthetic process#GO:0009889;regulation of catabolic process#GO:0009894;response to stress#GO:0006950;regulation of metabolic process#GO:0019222;response to nutrient levels#GO:0031667;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;cellular response to glucose starvation#GO:0042149;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007 nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;transferase complex, transferring phosphorus-containing groups#GO:0061695;transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;protein kinase complex#GO:1902911 kinase modulator#PC00140 Gonadotropin-releasing hormone receptor pathway#P06664>AMPK#P06830 HUMAN|HGNC=11793|UniProtKB=P52888 P52888 THOP1 PTHR11804:SF50 PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED THIMET OLIGOPEPTIDASE endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 protease#PC00190;metalloprotease#PC00153 HUMAN|HGNC=21964|UniProtKB=Q96M69 Q96M69 LRGUK PTHR23117:SF18 GUANYLATE KINASE-RELATED LEUCINE-RICH REPEAT AND GUANYLATE KINASE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleobase-containing compound kinase activity#GO:0019205;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, phosphate group as acceptor#GO:0016776 microtubule bundle formation#GO:0001578;sexual reproduction#GO:0019953;organelle assembly#GO:0070925;nucleoside diphosphate metabolic process#GO:0009132;multicellular organismal reproductive process#GO:0048609;axoneme assembly#GO:0035082;microtubule cytoskeleton organization#GO:0000226;organophosphate biosynthetic process#GO:0090407;developmental process involved in reproduction#GO:0003006;primary metabolic process#GO:0044238;reproductive process#GO:0022414;nucleoside phosphate metabolic process#GO:0006753;purine ribonucleoside diphosphate metabolic process#GO:0009179;developmental process#GO:0032502;spermatogenesis#GO:0007283;plasma membrane bounded cell projection assembly#GO:0120031;nucleoside phosphate biosynthetic process#GO:1901293;carbohydrate derivative metabolic process#GO:1901135;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;plasma membrane bounded cell projection organization#GO:0120036;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;male gamete generation#GO:0048232;purine nucleoside diphosphate metabolic process#GO:0009135;ribonucleotide metabolic process#GO:0009259;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;cilium organization#GO:0044782;nucleotide biosynthetic process#GO:0009165;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;ribonucleoside diphosphate metabolic process#GO:0009185;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;cellular component organization#GO:0016043;cilium assembly#GO:0060271;phosphorus metabolic process#GO:0006793;gamete generation#GO:0007276;cell projection organization#GO:0030030;small molecule metabolic process#GO:0044281;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;microtubule-based process#GO:0007017;nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative biosynthetic process#GO:1901137;cellular component organization or biogenesis#GO:0071840;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;cell projection assembly#GO:0030031;ribose phosphate biosynthetic process#GO:0046390;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607 intracellular organelle#GO:0043229;acrosomal vesicle#GO:0001669;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;vesicle#GO:0031982;secretory vesicle#GO:0099503;intracellular vesicle#GO:0097708;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 kinase#PC00137;transferase#PC00220 HUMAN|HGNC=20310|UniProtKB=Q5TC63 Q5TC63 GRTP1 PTHR22957:SF686 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN GROWTH HORMONE-REGULATED TBC PROTEIN 1 enzyme activator activity#GO:0008047;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886 G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HUMAN|HGNC=19195|UniProtKB=Q6H8Q1 Q6H8Q1 ABLIM2 PTHR24213:SF6 ACTIN-BINDING LIM PROTEIN ACTIN-BINDING LIM PROTEIN 2 binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;actin filament binding#GO:0051015;protein binding#GO:0005515;protein-containing complex binding#GO:0044877 plasma membrane bounded cell projection assembly#GO:0120031;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cell projection assembly#GO:0030031;lamellipodium assembly#GO:0030032;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cell projection organization#GO:0030030 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;actin cytoskeleton#GO:0015629;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=19440|UniProtKB=Q9Y3A5 Q9Y3A5 SBDS PTHR10927:SF6 RIBOSOME MATURATION PROTEIN SBDS RIBOSOME MATURATION PROTEIN SBDS RNA metabolism protein#PC00031 HUMAN|HGNC=16998|UniProtKB=P49755 P49755 TMED10 PTHR22811:SF183 TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN 10 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;cargo adaptor activity#GO:0140312 intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;intracellular protein transport#GO:0006886;transport#GO:0006810;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;endomembrane system organization#GO:0010256;cellular localization#GO:0051641;localization#GO:0051179;protein transport#GO:0015031;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular component organization#GO:0016043;Golgi organization#GO:0007030 cytoplasm#GO:0005737;COPI-coated vesicle#GO:0030137;endomembrane system#GO:0012505;endoplasmic reticulum#GO:0005783;Golgi-associated vesicle#GO:0005798;Golgi apparatus#GO:0005794;vesicle#GO:0031982;intracellular vesicle#GO:0097708;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;coated vesicle#GO:0030135;COPII-coated ER to Golgi transport vesicle#GO:0030134 vesicle coat protein#PC00235;membrane traffic protein#PC00150 HUMAN|HGNC=10417|UniProtKB=P62979 P62979 RPS27A PTHR10666:SF438 UBIQUITIN UBIQUITIN-RIBOSOMAL PROTEIN ES31 FUSION PROTEIN structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;catabolic process#GO:0009056;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;protein modification process#GO:0036211;primary metabolic process#GO:0044238;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein modification by small protein conjugation or removal#GO:0070647 cytosolic ribosome#GO:0022626;cytosol#GO:0005829;nucleus#GO:0005634;ribosome#GO:0005840;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=27039|UniProtKB=Q86Y79 Q86Y79 PTRH1 PTHR17224:SF1 PEPTIDYL-TRNA HYDROLASE PEPTIDYL-TRNA HYDROLASE hydrolase activity#GO:0016787;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;carboxylic ester hydrolase activity#GO:0052689 esterase#PC00097;hydrolase#PC00121 HUMAN|HGNC=8663|UniProtKB=Q9Y5I3 Q9Y5I3 PCDHA1 PTHR24028:SF92 CADHERIN-87A PROTOCADHERIN ALPHA-1 cellular process#GO:0009987;cell adhesion#GO:0007155 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 cadherin#PC00057;cell adhesion molecule#PC00069 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HUMAN|HGNC=6370|UniProtKB=Q9UKQ9 Q9UKQ9 KLK9 PTHR24271:SF57 KALLIKREIN-RELATED KALLIKREIN-9 peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;catalytic activity#GO:0003824;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;serine-type peptidase activity#GO:0008236 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238 extracellular region#GO:0005576;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;secretory vesicle#GO:0099503;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 serine protease#PC00203 HUMAN|HGNC=20066|UniProtKB=Q70CQ2 Q70CQ2 USP34 PTHR24006:SF827 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 34 hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;cysteine-type deubiquitinase activity#GO:0004843 regulation of protein stability#GO:0031647;biological regulation#GO:0065007;regulation of biological quality#GO:0065008 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 protease#PC00190;cysteine protease#PC00081 HUMAN|HGNC=4533|UniProtKB=Q96P67 Q96P67 GPR82 PTHR47392:SF1 G-PROTEIN COUPLED RECEPTOR 82-RELATED G PROTEIN-COUPLED RECEPTOR 82-RELATED transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=53652|UniProtKB=A8MXE2 A8MXE2 B3GALT9 PTHR11214:SF29 BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE BETA-1,3-GALACTOSYLTRANSFERASE 9 transferase activity#GO:0016740;catalytic activity#GO:0003824;glycosyltransferase activity#GO:0016757 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226 glycosyltransferase#PC00111;transferase#PC00220 HUMAN|HGNC=2389|UniProtKB=P02511 P02511 CRYAB PTHR45640:SF5 HEAT SHOCK PROTEIN HSP-12.2-RELATED ALPHA-CRYSTALLIN B CHAIN biosynthetic process#GO:0009058;biological regulation#GO:0065007;response to temperature stimulus#GO:0009266;gene expression#GO:0010467;protein maturation#GO:0051604;negative regulation of apoptotic process#GO:0043066;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;negative regulation of programmed cell death#GO:0043069;response to stress#GO:0006950;response to heat#GO:0009408;macromolecule metabolic process#GO:0043170;regulation of apoptotic process#GO:0042981;negative regulation of cellular process#GO:0048523;metabolic process#GO:0008152;protein folding#GO:0006457;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;primary metabolic process#GO:0044238;response to abiotic stimulus#GO:0009628;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;protein refolding#GO:0042026;protein metabolic process#GO:0019538 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 chaperone#PC00072 VEGF signaling pathway#P00056>HSP27#P01412;Angiogenesis#P00005>HSP27#P00231 HUMAN|HGNC=20455|UniProtKB=Q96EP1 Q96EP1 CHFR PTHR16079:SF4 UBIQUITIN LIGASE PROTEIN CHFR E3 UBIQUITIN-PROTEIN LIGASE CHFR catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-like protein transferase activity#GO:0019787 regulation of cell cycle process#GO:0010564;cell cycle checkpoint signaling#GO:0000075;negative regulation of mitotic cell cycle phase transition#GO:1901991;negative regulation of G2/M transition of mitotic cell cycle#GO:0010972;signal transduction#GO:0007165;cellular process#GO:0009987;negative regulation of cell cycle G2/M phase transition#GO:1902750;negative regulation of cell cycle#GO:0045786;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;signaling#GO:0023052;regulation of cell cycle#GO:0051726;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;cell cycle process#GO:0022402;negative regulation of biological process#GO:0048519;negative regulation of cell cycle phase transition#GO:1901988;negative regulation of mitotic cell cycle#GO:0045930;regulation of mitotic cell cycle phase transition#GO:1901990;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;biological regulation#GO:0065007;mitotic G2/M transition checkpoint#GO:0044818;regulation of mitotic cell cycle#GO:0007346;regulation of cell cycle G2/M phase transition#GO:1902749;mitotic cell cycle process#GO:1903047;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;negative regulation of cell cycle process#GO:0010948;negative regulation of cellular process#GO:0048523;catabolic process#GO:0009056;mitotic cell cycle#GO:0000278;regulation of cellular process#GO:0050794;modification-dependent protein catabolic process#GO:0019941;cellular response to stimulus#GO:0051716;mitotic cell cycle checkpoint signaling#GO:0007093;cell cycle#GO:0007049;regulation of cell cycle phase transition#GO:1901987;primary metabolic process#GO:0044238;intracellular signal transduction#GO:0035556;regulation of G2/M transition of mitotic cell cycle#GO:0010389;cell communication#GO:0007154;protein metabolic process#GO:0019538 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=19070|UniProtKB=Q96FV9 Q96FV9 THOC1 PTHR13265:SF2 THO COMPLEX SUBUNIT 1 THO COMPLEX SUBUNIT 1 macromolecule localization#GO:0033036;nitrogen compound transport#GO:0071705;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;biosynthetic process#GO:0009058;metabolic process#GO:0008152;RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907;transport#GO:0006810;macromolecule metabolic process#GO:0043170;establishment of localization#GO:0051234;nucleobase-containing compound transport#GO:0015931;RNA transport#GO:0050658;RNA localization#GO:0006403;establishment of RNA localization#GO:0051236;mRNA transport#GO:0051028;nucleocytoplasmic transport#GO:0006913;localization#GO:0051179;nucleic acid transport#GO:0050657;mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;nuclear transport#GO:0051169;nuclear export#GO:0051168 nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;transcription export complex#GO:0000346;intracellular organelle#GO:0043229;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;THO complex#GO:0000347;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 RNA metabolism protein#PC00031 HUMAN|HGNC=7632|UniProtKB=P54802 P54802 NAGLU PTHR12872:SF5 ALPHA-N-ACETYLGLUCOSAMINIDASE ALPHA-N-ACETYLGLUCOSAMINIDASE catalytic activity#GO:0003824;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787 carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;primary metabolic process#GO:0044238;proteoglycan metabolic process#GO:0006029;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;vacuole#GO:0005773;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HUMAN|HGNC=616|UniProtKB=P02749 P02749 APOH PTHR19325:SF549 COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING BETA-2-GLYCOPROTEIN 1 defense/immunity protein#PC00090;complement component#PC00078 HUMAN|HGNC=1095|UniProtKB=P17213 P17213 BPI PTHR10504:SF84 BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED BACTERICIDAL PERMEABILITY-INCREASING PROTEIN lipid binding#GO:0008289;lipopolysaccharide binding#GO:0001530;carbohydrate derivative binding#GO:0097367;binding#GO:0005488 response to lipopolysaccharide#GO:0032496;cell surface receptor signaling pathway#GO:0007166;negative regulation of leukocyte activation#GO:0002695;regulation of multicellular organismal process#GO:0051239;response to chemical#GO:0042221;response to lipid#GO:0033993;cellular response to lipid#GO:0071396;defense response to other organism#GO:0098542;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;regulation of macrophage activation#GO:0043030;defense response to symbiont#GO:0140546;cellular process#GO:0009987;response to biotic stimulus#GO:0009607;negative regulation of macromolecule biosynthetic process#GO:0010558;response to stress#GO:0006950;cellular response to lipopolysaccharide#GO:0071222;response to oxygen-containing compound#GO:1901700;defense response to bacterium#GO:0042742;immune system process#GO:0002376;cellular response to chemical stimulus#GO:0070887;signaling#GO:0023052;negative regulation of metabolic process#GO:0009892;biological process involved in interspecies interaction between organisms#GO:0044419;defense response to Gram-negative bacterium#GO:0050829;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;response to molecule of bacterial origin#GO:0002237;regulation of cell activation#GO:0050865;regulation of leukocyte activation#GO:0002694;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;response to external stimulus#GO:0009605;defense response#GO:0006952;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular response to molecule of bacterial origin#GO:0071219;innate immune response#GO:0045087;negative regulation of cell activation#GO:0050866;negative regulation of cellular process#GO:0048523;negative regulation of biosynthetic process#GO:0009890;negative regulation of immune system process#GO:0002683;biological regulation#GO:0065007;response to other organism#GO:0051707;negative regulation of macromolecule metabolic process#GO:0010605;immune response#GO:0006955;regulation of cytokine production#GO:0001817;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;cell communication#GO:0007154;lipopolysaccharide-mediated signaling pathway#GO:0031663;response to bacterium#GO:0009617;response to external biotic stimulus#GO:0043207;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;cellular response to stimulus#GO:0051716;negative regulation of multicellular organismal process#GO:0051241;cellular response to biotic stimulus#GO:0071216 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090 HUMAN|HGNC=28277|UniProtKB=Q8N8B7 Q8N8B7 TCEANC PTHR11477:SF7 TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN TRANSCRIPTION ELONGATION FACTOR A N-TERMINAL AND CENTRAL DOMAIN-CONTAINING PROTEIN transcription elongation factor activity#GO:0003711;transcription regulator activity#GO:0140110 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;DNA-templated transcription elongation#GO:0006354;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;transcription elongation by RNA polymerase II#GO:0006368;gene expression#GO:0010467;transcription by RNA polymerase II#GO:0006366;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031;general transcription factor#PC00259 HUMAN|HGNC=19287|UniProtKB=Q5MAI5 Q5MAI5 CDKL4 PTHR24056:SF120 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE-LIKE 4 protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=17720|UniProtKB=Q9BX95 Q9BX95 SGPP1 PTHR14969:SF45 SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE SPHINGOSINE-1-PHOSPHATE PHOSPHATASE 1 hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 lipid modification#GO:0030258;dephosphorylation#GO:0016311;lipid metabolic process#GO:0006629;alcohol metabolic process#GO:0006066;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;small molecule metabolic process#GO:0044281;phosphate-containing compound metabolic process#GO:0006796;cellular process#GO:0009987;phospholipid dephosphorylation#GO:0046839;primary metabolic process#GO:0044238 membrane#GO:0016020;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622 phosphatase#PC00181;hydrolase#PC00121 HUMAN|HGNC=15506|UniProtKB=Q9BSV6 Q9BSV6 TSEN34 PTHR13070:SF0 TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34-RELATED TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34 RNA nuclease activity#GO:0004540;endonuclease activity#GO:0004519;catalytic activity, acting on RNA#GO:0140098;RNA endonuclease activity#GO:0004521;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;nuclease activity#GO:0004518;catalytic activity, acting on a tRNA#GO:0140101;lyase activity#GO:0016829 RNA splicing#GO:0008380;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;tRNA splicing, via endonucleolytic cleavage and ligation#GO:0006388;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;endoribonuclease complex#GO:1902555;endonuclease complex#GO:1905348;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 RNA metabolism protein#PC00031;endoribonuclease#PC00094 HUMAN|HGNC=25924|UniProtKB=Q96K31 Q96K31 C8orf76 PTHR31919:SF1 ZINC FINGERS AND HOMEOBOXES PROTEIN 1, ISOFORM 2 ZINC FINGERS AND HOMEOBOXES PROTEIN 1, ISOFORM 2 homeodomain transcription factor#PC00119 HUMAN|HGNC=2936|UniProtKB=Q09019 Q09019 DMWD PTHR14107:SF15 WD REPEAT PROTEIN DYSTROPHIA MYOTONICA WD REPEAT-CONTAINING PROTEIN enzyme activator activity#GO:0008047;peptidase activator activity#GO:0016504;peptidase regulator activity#GO:0061134;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772 negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of catabolic process#GO:0009895;regulation of protein catabolic process#GO:0042176;biological regulation#GO:0065007;negative regulation of protein catabolic process#GO:0042177;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;negative regulation of ubiquitin-dependent protein catabolic process#GO:2000059;regulation of catabolic process#GO:0009894;negative regulation of cellular process#GO:0048523;regulation of ubiquitin-dependent protein catabolic process#GO:2000058 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=17899|UniProtKB=Q9NYS0 Q9NYS0 NKIRAS1 PTHR46152:SF1 NF-KAPPA-B INHIBITOR-INTERACTING RAS-LIKE PROTEIN NF-KAPPA-B INHIBITOR-INTERACTING RAS-LIKE PROTEIN 1 binding#GO:0005488;protein binding#GO:0005515 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;small GTPase-mediated signal transduction#GO:0007264;signaling#GO:0023052;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 HUMAN|HGNC=20730|UniProtKB=Q7Z3E5 Q7Z3E5 ARMC9 PTHR14881:SF4 LISH DOMAIN-CONTAINING PROTEIN ARMC9 LISH DOMAIN-CONTAINING PROTEIN ARMC9 cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;plasma membrane bounded cell projection organization#GO:0120036;cell projection organization#GO:0030030;cellular component assembly#GO:0022607;plasma membrane bounded cell projection assembly#GO:0120031;organelle assembly#GO:0070925;cilium organization#GO:0044782;cellular component organization or biogenesis#GO:0071840 microtubule cytoskeleton#GO:0015630;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;centriole#GO:0005814;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;intracellular organelle#GO:0043229;cilium#GO:0005929;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=19893|UniProtKB=Q6QNK2 Q6QNK2 ADGRD1 PTHR12011:SF216 ADHESION G-PROTEIN COUPLED RECEPTOR ADHESION G PROTEIN-COUPLED RECEPTOR D1 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=5273|UniProtKB=P98160 P98160 HSPG2 PTHR12231:SF280 CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN BASEMENT MEMBRANE-SPECIFIC HEPARAN SULFATE PROTEOGLYCAN CORE PROTEIN cell adhesion mediator activity#GO:0098631;cell adhesion molecule binding#GO:0050839;binding#GO:0005488;protein binding#GO:0005515 cellular process#GO:0009987;cell adhesion#GO:0007155;cell-cell adhesion#GO:0098609 cell junction#GO:0030054;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025 immunoglobulin superfamily cell adhesion molecule#PC00125;cell adhesion molecule#PC00069 HUMAN|HGNC=25384|UniProtKB=Q9H069 Q9H069 DRC3 PTHR45973:SF12 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED DYNEIN REGULATORY COMPLEX SUBUNIT 3 cilium#GO:0005929;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;membrane-bounded organelle#GO:0043227 protein-binding activity modulator#PC00095;phosphatase modulator#PC00184 HUMAN|HGNC=4920|UniProtKB=P15822 P15822 HIVEP1 PTHR45944:SF3 SCHNURRI, ISOFORM F ZINC FINGER PROTEIN 40 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=10768|UniProtKB=O75533 O75533 SF3B1 PTHR12097:SF0 SPLICING FACTOR 3B, SUBUNIT 1-RELATED SPLICING FACTOR 3B SUBUNIT 1 mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 cellular component organization#GO:0016043;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;protein-containing complex assembly#GO:0065003;mRNA cis splicing, via spliceosome#GO:0045292;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;ribonucleoprotein complex biogenesis#GO:0022613;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;spliceosomal complex assembly#GO:0000245;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;protein-RNA complex assembly#GO:0022618;mRNA processing#GO:0006397;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component assembly#GO:0022607;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;protein-RNA complex organization#GO:0071826;protein-containing complex organization#GO:0043933 nuclear protein-containing complex#GO:0140513;U12-type spliceosomal complex#GO:0005689;Sm-like protein family complex#GO:0120114;catalytic step 2 spliceosome#GO:0071013;U2 snRNP#GO:0005686;protein-containing complex#GO:0032991;small nuclear ribonucleoprotein complex#GO:0030532;nucleus#GO:0005634;spliceosomal snRNP complex#GO:0097525;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;organelle#GO:0043226;cellular anatomical structure#GO:0110165;U2-type prespliceosome#GO:0071004;intracellular membrane-bounded organelle#GO:0043231;U2-type spliceosomal complex#GO:0005684;spliceosomal complex#GO:0005681 RNA processing factor#PC00147;RNA splicing factor#PC00148 HUMAN|HGNC=4047|UniProtKB=O00144 O00144 FZD9 PTHR11309:SF79 FRIZZLED FRIZZLED-9 Wnt-protein binding#GO:0017147;protein binding#GO:0005515;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888 biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;Wnt signaling pathway#GO:0016055;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;non-canonical Wnt signaling pathway#GO:0035567;cell communication#GO:0007154;canonical Wnt signaling pathway#GO:0060070;cell surface receptor signaling pathway#GO:0007166 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 Alzheimer disease-presenilin pathway#P00004>Frizzled#P00119;Wnt signaling pathway#P00057>Frizzled#P01428;Cadherin signaling pathway#P00012>Frizzled#P00475 HUMAN|HGNC=25970|UniProtKB=Q8WVL7 Q8WVL7 ANKRD49 PTHR24180:SF47 CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 49 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA metabolic process#GO:0051252;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 kinase modulator#PC00140;kinase inhibitor#PC00139 HUMAN|HGNC=1984|UniProtKB=Q9NSE2 Q9NSE2 CISH PTHR10155:SF9 PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT CYTOKINE-INDUCIBLE SH2-CONTAINING PROTEIN protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102;cytokine receptor binding#GO:0005126 regulation of signaling#GO:0023051;cytokine-mediated signaling pathway#GO:0019221;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648;response to peptide#GO:1901652;cell communication#GO:0007154;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;negative regulation of biological process#GO:0048519;signaling#GO:0023052;regulation of receptor signaling pathway via STAT#GO:1904892;regulation of cell communication#GO:0010646;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;regulation of response to stimulus#GO:0048583;regulation of receptor signaling pathway via JAK-STAT#GO:0046425;negative regulation of cellular process#GO:0048523;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;response to cytokine#GO:0034097;response to chemical#GO:0042221;negative regulation of response to stimulus#GO:0048585 kinase modulator#PC00140 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>SOCS#P00879;Interferon-gamma signaling pathway#P00035>SOCS#P00956 HUMAN|Ensembl=ENSG00000292227.2|UniProtKB=A0AAG2UXD8 A0AAG2UXD8 LOC102724250 PTHR14199:SF35 NEUROBLASTOMA BREAKPOINT FAMILY MEMBER 6-LIKE PROTEIN NBPF FAMILY MEMBER NBPF1-RELATED HUMAN|HGNC=13005|UniProtKB=O14771 O14771 ZNF213 PTHR23226:SF258 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER PROTEIN 213 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=19859|UniProtKB=Q8N9U0 Q8N9U0 TC2N PTHR46887:SF1 TANDEM C2 DOMAINS NUCLEAR PROTEIN TANDEM C2 DOMAINS NUCLEAR PROTEIN HUMAN|HGNC=20303|UniProtKB=Q8IWU4 Q8IWU4 SLC30A8 PTHR11562:SF37 CATION EFFLUX PROTEIN/ ZINC TRANSPORTER PROTON-COUPLED ZINC ANTIPORTER SLC30A8 metal ion transmembrane transporter activity#GO:0046873;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;zinc ion transmembrane transporter activity#GO:0005385;transition metal ion transmembrane transporter activity#GO:0046915 response to metal ion#GO:0010038;transport#GO:0006810;intracellular protein localization#GO:0008104;establishment of protein localization to extracellular region#GO:0035592;establishment of localization#GO:0051234;peptide transport#GO:0015833;macromolecule localization#GO:0033036;nitrogen compound transport#GO:0071705;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;insulin secretion#GO:0030073;response to glucose#GO:0009749;peptide secretion#GO:0002790;signal release#GO:0023061;peptide hormone secretion#GO:0030072;cell communication#GO:0007154;localization#GO:0051179;monoatomic cation transport#GO:0006812;secretion#GO:0046903;protein localization to extracellular region#GO:0071692;metal ion transport#GO:0030001;hormone transport#GO:0009914;establishment of protein localization#GO:0045184;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;zinc ion transport#GO:0006829;response to chemical#GO:0042221;zinc ion transmembrane transport#GO:0071577;response to oxygen-containing compound#GO:1901700;transition metal ion transport#GO:0000041;response to monosaccharide#GO:0034284;response to carbohydrate#GO:0009743;secretion by cell#GO:0032940;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;hormone secretion#GO:0046879;protein transport#GO:0015031;protein secretion#GO:0009306;transmembrane transport#GO:0055085;regulation of biological process#GO:0050789;regulation of hormone levels#GO:0010817;response to hexose#GO:0009746;export from cell#GO:0140352;signaling#GO:0023052;response to stimulus#GO:0050896 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227 HUMAN|HGNC=12381|UniProtKB=Q01534 Q01534 TSPY1 PTHR11875:SF12 TESTIS-SPECIFIC Y-ENCODED PROTEIN TESTIS-SPECIFIC Y-ENCODED PROTEIN 1-RELATED protein binding#GO:0005515;chromatin binding#GO:0003682;histone binding#GO:0042393;binding#GO:0005488 intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;chromosome#GO:0005694;nucleus#GO:0005634;chromatin#GO:0000785;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=24819|UniProtKB=Q5SVQ8 Q5SVQ8 ZBTB41 PTHR23226:SF330 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 41 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=25049|UniProtKB=Q6NXE6 Q6NXE6 ARMC6 PTHR22895:SF9 ARMADILLO REPEAT-CONTAINING PROTEIN 6 ARMADILLO REPEAT-CONTAINING PROTEIN 6 cellular developmental process#GO:0048869;anatomical structure development#GO:0048856;cell differentiation#GO:0030154;cell development#GO:0048468;hemopoiesis#GO:0030097;cellular process#GO:0009987;developmental process#GO:0032502 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=13722|UniProtKB=P61970 P61970 NUTF2 PTHR12612:SF46 NUCLEAR TRANSPORT FACTOR 2 NUCLEAR TRANSPORT FACTOR 2 nucleocytoplasmic carrier activity#GO:0140142;molecular carrier activity#GO:0140104 protein localization to organelle#GO:0033365;nucleocytoplasmic transport#GO:0006913;nuclear transport#GO:0051169;protein import into nucleus#GO:0006606;protein transport#GO:0015031;localization#GO:0051179;cellular localization#GO:0051641;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule localization#GO:0033036;import into nucleus#GO:0051170;protein localization to nucleus#GO:0034504;transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;nuclear pore#GO:0005643;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=10418|UniProtKB=P62857 P62857 RPS28 PTHR10769:SF3 40S RIBOSOMAL PROTEIN S28 SMALL RIBOSOMAL SUBUNIT PROTEIN ES28 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 organelle assembly#GO:0070925;protein-RNA complex assembly#GO:0022618;rRNA processing#GO:0006364;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;rRNA metabolic process#GO:0016072;macromolecule metabolic process#GO:0043170;ribosomal small subunit assembly#GO:0000028;macromolecule biosynthetic process#GO:0009059;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;ribosome assembly#GO:0042255;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;ribonucleoprotein complex biogenesis#GO:0022613;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;ribosomal small subunit biogenesis#GO:0042274;cellular component organization or biogenesis#GO:0071840;protein-RNA complex organization#GO:0071826;protein-containing complex organization#GO:0043933;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cellular component assembly#GO:0022607;gene expression#GO:0010467;RNA processing#GO:0006396;maturation of SSU-rRNA#GO:0030490 small ribosomal subunit#GO:0015935;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;cytosolic small ribosomal subunit#GO:0022627;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;ribosome#GO:0005840;cytosolic ribosome#GO:0022626;cytosol#GO:0005829;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 ribosomal protein#PC00202 HUMAN|HGNC=43879|UniProtKB=P0DPI3 P0DPI3 CENPVL2 PTHR28620:SF8 CENTROMERE PROTEIN V CENTROMERE PROTEIN V-LIKE PROTEIN 2 HUMAN|HGNC=8215|UniProtKB=Q8NH93 Q8NH93 OR1L3 PTHR48001:SF49 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 1L3 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell communication#GO:0007154 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=1046|UniProtKB=O14503 O14503 BHLHE40 PTHR10985:SF3 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED CLASS E BASIC HELIX-LOOP-HELIX PROTEIN 40 DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;circadian rhythm#GO:0007623;rhythmic process#GO:0048511;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;circadian regulation of gene expression#GO:0032922;negative regulation of biological process#GO:0048519;regulation of multicellular organismal development#GO:2000026;regulation of biological process#GO:0050789;multicellular organism development#GO:0007275;anterior/posterior pattern specification#GO:0009952;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of multicellular organismal process#GO:0051239;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of nervous system development#GO:0051960;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;pattern specification process#GO:0007389;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of developmental process#GO:0050793;regulation of neurogenesis#GO:0050767;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;regulation of cell differentiation#GO:0045595;developmental process#GO:0032502;multicellular organismal process#GO:0032501;regionalization#GO:0003002;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of cell development#GO:0060284;negative regulation of macromolecule metabolic process#GO:0010605 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=24579|UniProtKB=O75838 O75838 CIB2 PTHR45791:SF5 CALCIUM AND INTEGRIN BINDING FAMILY MEMBER 2 CALCIUM AND INTEGRIN-BINDING FAMILY MEMBER 2 ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;calcium ion binding#GO:0005509;metal ion binding#GO:0046872;cation binding#GO:0043169;magnesium ion binding#GO:0000287 monoatomic cation homeostasis#GO:0055080;inorganic ion homeostasis#GO:0098771;chemical homeostasis#GO:0048878;monoatomic ion homeostasis#GO:0050801;calcium ion homeostasis#GO:0055074;homeostatic process#GO:0042592 cytoskeleton#GO:0005856;stereocilium#GO:0032420;membraneless organelle#GO:0043228;cell periphery#GO:0071944;neuron projection#GO:0043005;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cluster of actin-based cell projections#GO:0098862;actin-based cell projection#GO:0098858;actin cytoskeleton#GO:0015629;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226 Ras Pathway#P04393>Rac#P04559 HUMAN|HGNC=25067|UniProtKB=Q96CB8 Q96CB8 INTS12 PTHR13415:SF2 NUCLEAR FACTOR-RELATED INTEGRATOR COMPLEX SUBUNIT 12 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;snRNA processing#GO:0016180;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;snRNA 3'-end processing#GO:0034472;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;snRNA metabolic process#GO:0016073 intracellular organelle#GO:0043229;integrator complex#GO:0032039;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=12682|UniProtKB=P49767 P49767 VEGFC PTHR12025:SF3 VASCULAR ENDOTHELIAL GROWTH FACTOR VASCULAR ENDOTHELIAL GROWTH FACTOR C molecular function activator activity#GO:0140677;protein binding#GO:0005515;signaling receptor binding#GO:0005102;cytokine receptor binding#GO:0005126;binding#GO:0005488;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;growth factor receptor binding#GO:0070851;signaling receptor regulator activity#GO:0030545;growth factor activity#GO:0008083 positive regulation of immune system process#GO:0002684;response to stress#GO:0006950;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;regulation of response to external stimulus#GO:0032101;cell surface receptor signaling pathway#GO:0007166;positive regulation of response to external stimulus#GO:0032103;multicellular organism development#GO:0007275;vasculature development#GO:0001944;anatomical structure formation involved in morphogenesis#GO:0048646;blood vessel morphogenesis#GO:0048514;response to abiotic stimulus#GO:0009628;response to endogenous stimulus#GO:0009719;positive regulation of cell motility#GO:2000147;regulation of chemotaxis#GO:0050920;vascular endothelial growth factor receptor signaling pathway#GO:0048010;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;circulatory system development#GO:0072359;signaling#GO:0023052;animal gross anatomical part developmental process#GO:0160108;sprouting angiogenesis#GO:0002040;angiogenesis#GO:0001525;cellular response to growth factor stimulus#GO:0071363;positive regulation of cell migration#GO:0030335;positive regulation of cellular process#GO:0048522;multicellular organismal process#GO:0032501;positive regulation of response to stimulus#GO:0048584;regulation of locomotion#GO:0040012;tube development#GO:0035295;biological regulation#GO:0065007;regulation of response to stimulus#GO:0048583;developmental process#GO:0032502;regulation of cell migration#GO:0030334;positive regulation of locomotion#GO:0040017;response to hypoxia#GO:0001666;response to decreased oxygen levels#GO:0036293;response to oxygen levels#GO:0070482;cellular response to stimulus#GO:0051716;blood vessel development#GO:0001568;tube morphogenesis#GO:0035239;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;response to growth factor#GO:0070848;regulation of leukocyte migration#GO:0002685;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of chemotaxis#GO:0050921;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;regulation of cell motility#GO:2000145;system development#GO:0048731 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 growth factor#PC00112;intercellular signal molecule#PC00207 HUMAN|HGNC=53444|UniProtKB=E5RIL1 E5RIL1 UPK3BL2 PTHR15446:SF2 UROPLAKIN III UROPLAKIN-3B-LIKE PROTEIN 1-RELATED membrane#GO:0016020;cellular anatomical structure#GO:0110165 HUMAN|HGNC=16734|UniProtKB=Q86XN8 Q86XN8 MEX3D PTHR23285:SF3 RING FINGER AND KH DOMAIN CONTAINING PROTEIN 1 RNA-BINDING PROTEIN MEX3D RNA metabolism protein#PC00031 HUMAN|HGNC=9657|UniProtKB=P54829 P54829 PTPN5 PTHR46198:SF1 PROTEIN-TYROSINE-PHOSPHATASE TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 5 protein tyrosine phosphatase activity#GO:0004725;hydrolase activity#GO:0016787;protein binding#GO:0005515;phosphoprotein phosphatase activity#GO:0004721;binding#GO:0005488;kinase binding#GO:0019900;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;cell communication#GO:0007154 cell junction#GO:0030054;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cytoplasm#GO:0005737;cytosol#GO:0005829;membrane#GO:0016020;cell periphery#GO:0071944 protein modifying enzyme#PC00260;protein phosphatase#PC00195 HUMAN|HGNC=8565|UniProtKB=Q86U42 Q86U42 PABPN1 PTHR23236:SF16 EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H POLYADENYLATE-BINDING PROTEIN 2 single-stranded RNA binding#GO:0003727;RNA binding#GO:0003723;nucleic acid binding#GO:0003676;poly(A) binding#GO:0008143;binding#GO:0005488 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 translational protein#PC00263;translation factor#PC00223;translation initiation factor#PC00224 HUMAN|HGNC=35240|UniProtKB=A6NCL7 A6NCL7 ANKRD33B PTHR24173:SF1 ANKYRIN REPEAT CONTAINING ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 33B scaffold/adaptor protein#PC00226 HUMAN|HGNC=9922|UniProtKB=P02753 P02753 RBP4 PTHR11873:SF2 RETINOL-BINDING PROTEIN 4 RETINOL-BINDING PROTEIN 4 binding#GO:0005488;small molecule binding#GO:0036094;lipid binding#GO:0008289;alcohol binding#GO:0043178 transport#GO:0006810;lipid localization#GO:0010876;macromolecule localization#GO:0033036;organic hydroxy compound transport#GO:0015850;establishment of localization#GO:0051234;localization#GO:0051179;lipid transport#GO:0006869 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 transfer/carrier protein#PC00219 HUMAN|HGNC=28797|UniProtKB=Q6ZMB5 Q6ZMB5 TMEM184A PTHR23423:SF59 ORGANIC SOLUTE TRANSPORTER-RELATED TRANSMEMBRANE PROTEIN 184A transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;cytoplasm#GO:0005737;membrane#GO:0016020;vesicle membrane#GO:0012506;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;early endosome membrane#GO:0031901;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;endosome membrane#GO:0010008;endosome#GO:0005768;intracellular organelle#GO:0043229 transporter#PC00227 HUMAN|HGNC=10362|UniProtKB=Q02878 Q02878 RPL6 PTHR10715:SF7 60S RIBOSOMAL PROTEIN L6 LARGE RIBOSOMAL SUBUNIT PROTEIN EL6 structural molecule activity#GO:0005198;RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;structural constituent of ribosome#GO:0003735 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;translation#GO:0006412;metabolic process#GO:0008152;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;cytoplasmic translation#GO:0002181;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;ribosome#GO:0005840;cytosol#GO:0005829;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625 ribosomal protein#PC00202 HUMAN|HGNC=26560|UniProtKB=Q96M63 Q96M63 ODAD1 PTHR21694:SF35 COILED-COIL DOMAIN-CONTAINING PROTEIN 63 OUTER DYNEIN ARM-DOCKING COMPLEX SUBUNIT 1 microtubule-based movement#GO:0007018;cell projection organization#GO:0030030;cilium assembly#GO:0060271;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;microtubule cytoskeleton organization#GO:0000226;cilium organization#GO:0044782;axoneme assembly#GO:0035082;organelle assembly#GO:0070925;axonemal dynein complex assembly#GO:0070286;microtubule bundle formation#GO:0001578;cilium movement#GO:0003341;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;outer dynein arm assembly#GO:0036158;cell projection assembly#GO:0030031;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;microtubule-based process#GO:0007017;plasma membrane bounded cell projection assembly#GO:0120031 organelle#GO:0043226;cellular anatomical structure#GO:0110165;ciliary plasm#GO:0097014;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;cytoskeleton#GO:0005856;cilium#GO:0005929;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;axoneme#GO:0005930;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=1580|UniProtKB=O95067 O95067 CCNB2 PTHR10177:SF184 CYCLINS G2_MITOTIC-SPECIFIC CYCLIN-B2 enzyme regulator activity#GO:0030234;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;protein kinase regulator activity#GO:0019887;cyclin-dependent protein kinase regulator activity#GO:0019914;cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538 mitotic cell cycle process#GO:1903047;G1/S transition of mitotic cell cycle#GO:0000082;mitotic cell cycle phase transition#GO:0044772;cell cycle phase transition#GO:0044770;mitotic cell cycle#GO:0000278;cellular process#GO:0009987;cell cycle process#GO:0022402;cell cycle G1/S phase transition#GO:0044843;cell cycle#GO:0007049 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;protein kinase complex#GO:1902911;membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex#GO:1990234;transferase complex, transferring phosphorus-containing groups#GO:0061695 kinase activator#PC00138 HUMAN|HGNC=3601|UniProtKB=P98095 P98095 FBLN2 PTHR24039:SF32 FIBRILLIN-RELATED FIBULIN-2 extracellular matrix binding#GO:0050840;structural molecule activity#GO:0005198;binding#GO:0005488;extracellular matrix structural constituent#GO:0005201 positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;positive regulation of biological process#GO:0048518;positive regulation of cell-substrate adhesion#GO:0010811;positive regulation of cell adhesion#GO:0045785;regulation of cell adhesion#GO:0030155;regulation of cellular process#GO:0050794;regulation of cell-substrate adhesion#GO:0010810;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 extracellular matrix structural protein#PC00103 HUMAN|HGNC=12261|UniProtKB=Q13061 Q13061 TRDN PTHR14106:SF0 TRIADIN TRIADIN protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum#GO:0014808;monoatomic ion transmembrane transport#GO:0034220;regulation of calcium ion transport#GO:0051924;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;blood circulation#GO:0008015;regulation of monoatomic ion transport#GO:0043269;transport#GO:0006810;regulation of monoatomic cation transmembrane transport#GO:1904062;system process#GO:0003008;heart contraction#GO:0060047;establishment of localization#GO:0051234;regulation of transmembrane transport#GO:0034762;metal ion transport#GO:0030001;regulation of cellular process#GO:0050794;regulation of metal ion transport#GO:0010959;circulatory system process#GO:0003013;monoatomic cation transport#GO:0006812;localization#GO:0051179;regulation of monoatomic ion transmembrane transport#GO:0034765;cellular process#GO:0009987;release of sequestered calcium ion into cytosol#GO:0051209;monoatomic cation transmembrane transport#GO:0098655;regulation of release of sequestered calcium ion into cytosol#GO:0051279;calcium ion transport#GO:0006816;regulation of localization#GO:0032879;regulation of transport#GO:0051049;calcium ion transmembrane import into cytosol#GO:0097553;regulation of membrane potential#GO:0042391;heart process#GO:0003015;regulation of biological process#GO:0050789;calcium ion transmembrane transport#GO:0070588;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;transmembrane transport#GO:0055085 cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;sarcoplasm#GO:0016528;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;sarcoplasmic reticulum membrane#GO:0033017;cytoplasm#GO:0005737;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;sarcoplasmic reticulum#GO:0016529;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783 HUMAN|HGNC=32268|UniProtKB=A6NIJ5 A6NIJ5 FAM90A20 PTHR16035:SF14 PROTEIN FAM90A1 PROTEIN FAM90A10-RELATED HUMAN|HGNC=20503|UniProtKB=Q71DI3 Q71DI3 H3C15 PTHR11426:SF265 HISTONE H3 HISTONE H3.2 chromosome organization#GO:0051276;protein-containing complex organization#GO:0043933;mitotic cell cycle process#GO:1903047;cellular component organization or biogenesis#GO:0071840;chromosome segregation#GO:0007059;metaphase chromosome alignment#GO:0051310;chromosome localization#GO:0050000;cellular component assembly#GO:0022607;cellular process#GO:0009987;mitotic sister chromatid segregation#GO:0000070;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;organelle fission#GO:0048285;kinetochore organization#GO:0051383;localization#GO:0051179;kinetochore assembly#GO:0051382;nuclear division#GO:0000280;organelle localization#GO:0051640;organelle assembly#GO:0070925;mitotic cell cycle#GO:0000278;cell cycle process#GO:0022402;mitotic nuclear division#GO:0140014;mitotic metaphase chromosome alignment#GO:0007080;protein-containing complex assembly#GO:0065003;nuclear chromosome segregation#GO:0098813;membraneless organelle assembly#GO:0140694;sister chromatid segregation#GO:0000819;cellular component organization#GO:0016043;cell cycle#GO:0007049 chromatin/chromatin-binding, or -regulatory protein#PC00077 DNA replication#P00017>Histones#P00527 HUMAN|HGNC=3477|UniProtKB=P62495 P62495 ETF1 PTHR10113:SF21 PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1 EUKARYOTIC PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;translation factor activity#GO:0180051 protein biosynthetic process#GO:0160307;cytoplasmic translation#GO:0002181;protein-containing complex disassembly#GO:0032984;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;cellular component disassembly#GO:0022411;protein metabolic process#GO:0019538;translational termination#GO:0006415;translation#GO:0006412;gene expression#GO:0010467;biosynthetic process#GO:0009058;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-containing complex organization#GO:0043933;metabolic process#GO:0008152 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 translation factor#PC00223;translation release factor#PC00225 HUMAN|HGNC=17894|UniProtKB=Q14966 Q14966 ZNF638 PTHR15592:SF1 MATRIN 3/NUCLEAR PROTEIN 220-RELATED ZINC FINGER PROTEIN 638 RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 RNA processing factor#PC00147 HUMAN|HGNC=6249|UniProtKB=Q9UJ96 Q9UJ96 KCNG2 PTHR11537:SF90 VOLTAGE-GATED POTASSIUM CHANNEL VOLTAGE-GATED POTASSIUM CHANNEL REGULATORY SUBUNIT KCNG2 molecular function regulator activity#GO:0098772;channel regulator activity#GO:0016247;transporter regulator activity#GO:0141108;potassium channel regulator activity#GO:0015459;ion channel regulator activity#GO:0099106 action potential#GO:0001508;metal ion transport#GO:0030001;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813;transport#GO:0006810;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391 cation channel complex#GO:0034703;voltage-gated potassium channel complex#GO:0008076;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991 ion channel#PC00133;voltage-gated ion channel#PC00241 HUMAN|HGNC=23370|UniProtKB=Q96H12 Q96H12 MSANTD3 PTHR21632:SF2 REGULATORY PROTEIN ZESTE MYB_SANT-LIKE DNA-BINDING DOMAIN-CONTAINING PROTEIN 3 HUMAN|HGNC=7664|UniProtKB=P16333 P16333 NCK1 PTHR19969:SF16 SH2-SH3 ADAPTOR PROTEIN-RELATED SH2_SH3 ADAPTER PROTEIN NCK1 receptor tyrosine kinase binding#GO:0030971;molecular adaptor activity#GO:0060090;signaling adaptor activity#GO:0035591;protein binding#GO:0005515;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;signaling receptor binding#GO:0005102;binding#GO:0005488;protein tyrosine kinase binding#GO:1990782;kinase binding#GO:0019900;protein-macromolecule adaptor activity#GO:0030674 regulation of intrinsic apoptotic signaling pathway#GO:2001242;cellular response to stimulus#GO:0051716;ephrin receptor signaling pathway#GO:0048013;regulation of response to endoplasmic reticulum stress#GO:1905897;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;positive regulation of apoptotic signaling pathway#GO:2001235;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;cell motility#GO:0048870;regulation of macromolecule metabolic process#GO:0060255;regulation of apoptotic signaling pathway#GO:2001233;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;response to endoplasmic reticulum stress#GO:0034976;positive regulation of translation#GO:0045727;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;positive regulation of biosynthetic process#GO:0009891;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of response to stimulus#GO:0048585;cell migration#GO:0016477;positive regulation of response to stimulus#GO:0048584;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;regulation of response to stress#GO:0080134;regulation of gene expression#GO:0010468;positive regulation of gene expression#GO:0010628;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;signaling#GO:0023052;positive regulation of programmed cell death#GO:0043068;response to stimulus#GO:0050896;regulation of signaling#GO:0023051;positive regulation of protein metabolic process#GO:0051247;cellular response to stress#GO:0033554;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648;regulation of cellular response to stress#GO:0080135;positive regulation of signaling#GO:0023056;negative regulation of intracellular signal transduction#GO:1902532;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;response to stress#GO:0006950;regulation of protein metabolic process#GO:0051246;negative regulation of signal transduction#GO:0009968;positive regulation of macromolecule metabolic process#GO:0010604;cell surface receptor signaling pathway#GO:0007166;regulation of apoptotic process#GO:0042981;positive regulation of apoptotic process#GO:0043065 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 T cell activation#P00053>nck#P01314;PDGF signaling pathway#P00047>Grb2#P01148;Angiogenesis#P00005>Nck#P00215;PDGF signaling pathway#P00047>Nck#P01147 HUMAN|HGNC=17781|UniProtKB=Q969E3 Q969E3 UCN3 PTHR17575:SF1 UROCORTIN-2 AND 3 UROCORTIN-3 protein binding#GO:0005515;neuropeptide receptor binding#GO:0071855;signaling receptor binding#GO:0005102;hormone receptor binding#GO:0051427;binding#GO:0005488;G protein-coupled receptor binding#GO:0001664 G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cellular response to nutrient levels#GO:0031669;cell communication#GO:0007154;response to nutrient levels#GO:0031667;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=12235|UniProtKB=A0A0A6YYK4 A0A0A6YYK4 TRBV7-1 PTHR23268:SF108 T-CELL RECEPTOR BETA CHAIN T CELL RECEPTOR BETA VARIABLE 7-2-RELATED signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=20392|UniProtKB=Q8IWU5 Q8IWU5 SULF2 PTHR43108:SF4 N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER EXTRACELLULAR SULFATASE SULF-2 hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;protein catabolic process#GO:0030163;positive regulation of signaling#GO:0023056;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;positive regulation of multicellular organismal process#GO:0051240;regulation of biological process#GO:0050789;regulation of Wnt signaling pathway#GO:0030111;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;proteoglycan metabolic process#GO:0006029;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of Wnt signaling pathway#GO:0030177;positive regulation of macromolecule metabolic process#GO:0010604;regulation of multicellular organismal process#GO:0051239;negative regulation of signal transduction#GO:0009968;regulation of fibroblast growth factor receptor signaling pathway#GO:0040036;protein metabolic process#GO:0019538;positive regulation of biosynthetic process#GO:0009891;primary metabolic process#GO:0044238;positive regulation of signal transduction#GO:0009967;positive regulation of cell communication#GO:0010647;positive regulation of cytokine production#GO:0001819;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;regulation of cell communication#GO:0010646;carbohydrate derivative catabolic process#GO:1901136;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulation of gene expression#GO:0010468;positive regulation of gene expression#GO:0010628;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of cytokine production#GO:0001817;carbohydrate derivative metabolic process#GO:1901135;positive regulation of cellular process#GO:0048522;negative regulation of response to stimulus#GO:0048585;positive regulation of response to stimulus#GO:0048584;regulation of cellular response to growth factor stimulus#GO:0090287;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966 cell surface#GO:0009986;cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 hydrolase#PC00121 HUMAN|HGNC=23025|UniProtKB=Q8TD94 Q8TD94 KLF14 PTHR23235:SF59 KRUEPPEL-LIKE TRANSCRIPTION FACTOR KRUEPPEL-LIKE FACTOR 14 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=6058|UniProtKB=Q9NQS7 Q9NQS7 INCENP PTHR13142:SF1 INNER CENTROMERE PROTEIN INNER CENTROMERE PROTEIN membraneless organelle#GO:0043228;spindle#GO:0005819;cytoskeleton#GO:0005856;condensed chromosome#GO:0000793;chromosome, centromeric region#GO:0000775;intracellular membraneless organelle#GO:0043232;supramolecular complex#GO:0099080;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;nucleus#GO:0005634;microtubule cytoskeleton#GO:0015630;condensed chromosome, centromeric region#GO:0000779;membrane-bounded organelle#GO:0043227;spindle midzone#GO:0051233;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;kinetochore#GO:0000776;midbody#GO:0030496;chromosome#GO:0005694 HUMAN|HGNC=13964|UniProtKB=Q8NHA8 Q8NHA8 OR1F12P PTHR48001:SF69 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 1F12P-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=21307|UniProtKB=Q86SJ6 Q86SJ6 DSG4 PTHR24025:SF10 DESMOGLEIN FAMILY MEMBER DESMOGLEIN-4 calcium ion binding#GO:0005509;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;cation binding#GO:0043169;metal ion binding#GO:0046872 cellular process#GO:0009987;cell adhesion#GO:0007155;cell-cell adhesion#GO:0098609 cell-cell junction#GO:0005911;cell junction#GO:0030054;cellular anatomical structure#GO:0110165;anchoring junction#GO:0070161 cadherin#PC00057 HUMAN|HGNC=5387|UniProtKB=Q13907 Q13907 IDI1 PTHR10885:SF5 ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE 1 catalytic activity#GO:0003824;intramolecular oxidoreductase activity#GO:0016860;isomerase activity#GO:0016853 phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;phospholipid biosynthetic process#GO:0008654;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;isoprenoid biosynthetic process#GO:0008299;organophosphate biosynthetic process#GO:0090407;isoprenoid metabolic process#GO:0006720 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;peroxisome#GO:0005777;microbody#GO:0042579;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 isomerase#PC00135 Cholesterol biosynthesis#P00014>Isopentenyl diphosphate delta-isomerase#P00495 HUMAN|HGNC=51241|UniProtKB=A0A087WTH1 A0A087WTH1 TMEM265 PTHR48581:SF1 TRANSMEMBRANE PROTEIN 265 TRANSMEMBRANE PROTEIN 265 HUMAN|HGNC=6946|UniProtKB=O60318 O60318 MCM3AP PTHR12436:SF39 80 KDA MCM3-ASSOCIATED PROTEIN GERMINAL-CENTER ASSOCIATED NUCLEAR PROTEIN establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;metabolic process#GO:0008152;transport#GO:0006810;gene expression#GO:0010467;biosynthetic process#GO:0009058;nitrogen compound transport#GO:0071705;macromolecule localization#GO:0033036;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;establishment of localization in cell#GO:0051649;mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;nucleic acid transport#GO:0050657;localization#GO:0051179;nuclear export#GO:0051168;nuclear transport#GO:0051169;nucleocytoplasmic transport#GO:0006913;RNA localization#GO:0006403;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;mRNA transport#GO:0051028;establishment of RNA localization#GO:0051236 nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;transcription export complex 2#GO:0070390;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 scaffold/adaptor protein#PC00226 HUMAN|HGNC=2510|UniProtKB=P26232 P26232 CTNNA2 PTHR18914:SF23 ALPHA CATENIN CATENIN ALPHA-2 protein-containing complex binding#GO:0044877;beta-catenin binding#GO:0008013;protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;actin filament binding#GO:0051015;binding#GO:0005488 cellular process#GO:0009987;cell adhesion#GO:0007155;cell-cell adhesion#GO:0098609;cell motility#GO:0048870;cell migration#GO:0016477 extrinsic component of membrane#GO:0019898;cell junction#GO:0030054;extrinsic component of plasma membrane#GO:0019897;adherens junction#GO:0005912;anchoring junction#GO:0070161;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane protein complex#GO:0098796;cell-cell junction#GO:0005911;membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797 non-motor actin binding protein#PC00165 Wnt signaling pathway#P00057>alpha-catenin#P01471;Cadherin signaling pathway#P00012>alpha-catenin#P00467;Alzheimer disease-presenilin pathway#P00004>alpha-catenin#P00133 HUMAN|HGNC=1617|UniProtKB=P50991 P50991 CCT4 PTHR11353:SF26 CHAPERONIN T-COMPLEX PROTEIN 1 SUBUNIT DELTA metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;protein maturation#GO:0051604;protein folding#GO:0006457;biosynthetic process#GO:0009058 cytosol#GO:0005829;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;protein folding chaperone complex#GO:0101031;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;chaperonin-containing T-complex#GO:0005832 chaperonin#PC00073 HUMAN|HGNC=16278|UniProtKB=Q9C029 Q9C029 TRIM7 PTHR24103:SF700 E3 UBIQUITIN-PROTEIN LIGASE TRIM E3 UBIQUITIN-PROTEIN LIGASE TRIM7 ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824 innate immune response#GO:0045087;defense response#GO:0006952;response to external stimulus#GO:0009605;immune system process#GO:0002376;defense response to other organism#GO:0098542;response to stimulus#GO:0050896;response to other organism#GO:0051707;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;immune response#GO:0006955;defense response to symbiont#GO:0140546 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=25706|UniProtKB=Q6PJI9 Q6PJI9 WDR59 PTHR46170:SF1 GATOR COMPLEX PROTEIN WDR59 GATOR2 COMPLEX PROTEIN WDR59 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;signaling adaptor activity#GO:0035591 regulation of cell communication#GO:0010646;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to starvation#GO:0042594;positive regulation of signal transduction#GO:0009967;positive regulation of TOR signaling#GO:0032008;positive regulation of signaling#GO:0023056;cellular response to stress#GO:0033554;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;cellular response to amino acid starvation#GO:0034198;positive regulation of response to stimulus#GO:0048584;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;regulation of TOR signaling#GO:0032006;response to nutrient levels#GO:0031667;positive regulation of TORC1 signaling#GO:1904263;response to stress#GO:0006950;regulation of TORC1 signaling#GO:1903432;positive regulation of intracellular signal transduction#GO:1902533;cellular response to nutrient levels#GO:0031669;regulation of response to stimulus#GO:0048583;cellular response to starvation#GO:0009267 membrane#GO:0016020;vacuole#GO:0005773;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;Seh1-associated complex#GO:0035859;vacuolar membrane#GO:0005774 HUMAN|HGNC=6402|UniProtKB=O00410 O00410 IPO5 PTHR10527:SF22 IMPORTIN BETA IMPORTIN-5 nucleocytoplasmic carrier activity#GO:0140142;molecular carrier activity#GO:0140104 intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;protein localization to nucleus#GO:0034504;macromolecule localization#GO:0033036;import into nucleus#GO:0051170;nucleocytoplasmic transport#GO:0006913;protein import into nucleus#GO:0006606;protein transport#GO:0015031;nuclear transport#GO:0051169;cellular localization#GO:0051641;localization#GO:0051179;protein localization to organelle#GO:0033365 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634 transporter#PC00227 HUMAN|HGNC=25300|UniProtKB=Q6PCT2 Q6PCT2 FBXL19 PTHR23123:SF35 PHD/F-BOX CONTAINING PROTEIN F-BOX_LRR-REPEAT PROTEIN 19 catalytic activity, acting on a protein#GO:0140096;demethylase activity#GO:0032451;protein demethylase activity#GO:0140457;catalytic activity#GO:0003824;molecular adaptor activity#GO:0060090;enzyme-substrate adaptor activity#GO:0140767;histone demethylase activity#GO:0032452;ubiquitin-like ligase-substrate adaptor activity#GO:1990756;histone modifying activity#GO:0140993;protein-macromolecule adaptor activity#GO:0030674 protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;chromatin remodeling#GO:0006338;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;ubiquitin-dependent protein catabolic process#GO:0006511;cellular process#GO:0009987;chromatin organization#GO:0006325;proteasomal protein catabolic process#GO:0010498 nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;SCF ubiquitin ligase complex#GO:0019005;cullin-RING ubiquitin ligase complex#GO:0031461;transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ubiquitin ligase complex#GO:0000151;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227 histone modifying enzyme#PC00261;chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=18015|UniProtKB=Q9NRM6 Q9NRM6 IL17RB PTHR15583:SF11 INTERLEUKIN-17 RECEPTOR INTERLEUKIN-17 RECEPTOR B signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;immune receptor activity#GO:0140375;transmembrane signaling receptor activity#GO:0004888;cytokine receptor activity#GO:0004896 regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;response to chemical#GO:0042221;response to cytokine#GO:0034097;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cytokine production#GO:0001817;regulation of gene expression#GO:0010468;positive regulation of gene expression#GO:0010628;regulation of biosynthetic process#GO:0009889;cell surface receptor signaling pathway#GO:0007166;signaling#GO:0023052;positive regulation of cytokine production#GO:0001819;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;response to stimulus#GO:0050896;positive regulation of multicellular organismal process#GO:0051240;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;response to peptide#GO:1901652;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;cell communication#GO:0007154;positive regulation of biosynthetic process#GO:0009891;cytokine-mediated signaling pathway#GO:0019221 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=12586|UniProtKB=P22695 P22695 UQCRC2 PTHR11851:SF226 METALLOPROTEASE CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL protein localization to mitochondrion#GO:0070585;macromolecule localization#GO:0033036;intracellular protein localization#GO:0008104;localization#GO:0051179;protein localization to organelle#GO:0033365 respiratory chain complex#GO:0098803;membrane#GO:0016020;membrane-enclosed lumen#GO:0031974;oxidoreductase complex#GO:1990204;cytoplasm#GO:0005737;peptidase complex#GO:1905368;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;endopeptidase complex#GO:1905369;respiratory chain complex III#GO:0045275;transporter complex#GO:1990351;cytochrome complex#GO:0070069;mitochondrion#GO:0005739;organelle lumen#GO:0043233;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrial matrix#GO:0005759;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transmembrane transporter complex#GO:1902495 metalloprotease#PC00153;protease#PC00190 HUMAN|HGNC=7967|UniProtKB=Q96RI1 Q96RI1 NR1H4 PTHR24082:SF155 NUCLEAR HORMONE RECEPTOR BILE ACID RECEPTOR DNA binding#GO:0003677;nuclear receptor activity#GO:0004879;molecular transducer activity#GO:0060089;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;anion binding#GO:0043168;small molecule binding#GO:0036094;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;ion binding#GO:0043167;organic acid binding#GO:0043177;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulatory region nucleic acid binding#GO:0001067;binding#GO:0005488;carboxylic acid binding#GO:0031406;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;signaling receptor activity#GO:0038023;sequence-specific DNA binding#GO:0043565 positive regulation of transcription by RNA polymerase II#GO:0045944;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;chemical homeostasis#GO:0048878;negative regulation of macromolecule biosynthetic process#GO:0010558;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;regulation of response to external stimulus#GO:0032101;negative regulation of response to external stimulus#GO:0032102;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of biological process#GO:0048519;lipid homeostasis#GO:0055088;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;negative regulation of metabolic process#GO:0009892;regulation of response to stress#GO:0080134;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;regulation of response to stimulus#GO:0048583;cellular developmental process#GO:0048869;cholesterol homeostasis#GO:0042632;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of response to stimulus#GO:0048585;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of RNA biosynthetic process#GO:1902680;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of inflammatory response#GO:0050727;regulation of defense response#GO:0031347;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of inflammatory response#GO:0050728;negative regulation of defense response#GO:0031348;homeostatic process#GO:0042592;positive regulation of RNA metabolic process#GO:0051254 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229 C4 zinc finger nuclear receptor#PC00169 HUMAN|HGNC=23085|UniProtKB=O14559 O14559 ARHGAP33 PTHR15729:SF11 CDC42 GTPASE-ACTIVATING PROTEIN RHO GTPASE-ACTIVATING PROTEIN 33 enzyme activator activity#GO:0008047;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;intracellular signaling cassette#GO:0141124;signaling#GO:0023052;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264 protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HUMAN|HGNC=17579|UniProtKB=Q14849 Q14849 STARD3 PTHR46121:SF2 STEROIDOGENIC ACUTE REGULATORY PROTEIN-LIKE STAR-RELATED LIPID TRANSFER PROTEIN 3 steroid binding#GO:0005496;cholesterol binding#GO:0015485;lipid binding#GO:0008289;alcohol binding#GO:0043178;sterol binding#GO:0032934;small molecule binding#GO:0036094;binding#GO:0005488 lipid localization#GO:0010876;transport#GO:0006810;establishment of localization#GO:0051234;sterol transport#GO:0015918;localization#GO:0051179;organic hydroxy compound transport#GO:0015850;cholesterol transport#GO:0030301;macromolecule localization#GO:0033036;lipid transport#GO:0006869 organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endosome membrane#GO:0010008;endosome#GO:0005768;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;organelle membrane contact site#GO:0044232;vesicle#GO:0031982;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;late endosome membrane#GO:0031902;endoplasmic reticulum#GO:0005783;late endosome#GO:0005770;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;cytoplasm#GO:0005737;vesicle membrane#GO:0012506;membrane#GO:0016020 HUMAN|HGNC=3569|UniProtKB=P33121 P33121 ACSL1 PTHR43272:SF116 LONG-CHAIN-FATTY-ACID--COA LIGASE LONG-CHAIN-FATTY-ACID--COA LIGASE 1 catalytic activity#GO:0003824;ligase activity, forming carbon-sulfur bonds#GO:0016877;ligase activity#GO:0016874;ATP-dependent activity#GO:0140657 lipid metabolic process#GO:0006629;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;small molecule metabolic process#GO:0044281;cellular process#GO:0009987;long-chain fatty acid metabolic process#GO:0001676;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 ligase#PC00142 HUMAN|HGNC=219|UniProtKB=O15072 O15072 ADAMTS3 PTHR13723:SF158 ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 3 catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222 cellular process#GO:0009987;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;proteolysis#GO:0006508;metabolic process#GO:0008152;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;extracellular matrix organization#GO:0030198;protein metabolic process#GO:0019538 extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 HUMAN|HGNC=20679|UniProtKB=A1A5B4 A1A5B4 ANO9 PTHR12308:SF37 ANOCTAMIN ANOCTAMIN-9 lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104;transporter activity#GO:0005215;phospholipid scramblase activity#GO:0017128;intramembrane lipid carrier activity#GO:0140303 lipid transport#GO:0006869;biological regulation#GO:0065007;membrane organization#GO:0061024;endomembrane system organization#GO:0010256;phospholipid transport#GO:0015914;phospholipid translocation#GO:0045332;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;regulation of membrane lipid distribution#GO:0097035;transport#GO:0006810;organophosphate ester transport#GO:0015748;lipid translocation#GO:0034204;plasma membrane phospholipid scrambling#GO:0017121;cellular component organization#GO:0016043;localization#GO:0051179;plasma membrane organization#GO:0007009;regulation of biological quality#GO:0065008;lipid localization#GO:0010876 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=9081|UniProtKB=Q02809 Q02809 PLOD1 PTHR10730:SF5 PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE 1 dioxygenase activity#GO:0051213;oxidoreductase activity#GO:0016491;catalytic activity, acting on a protein#GO:0140096;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824 cellular process#GO:0009987;extracellular structure organization#GO:0043062;cellular component organization#GO:0016043;external encapsulating structure organization#GO:0045229;collagen fibril organization#GO:0030199;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;endoplasmic reticulum#GO:0005783;extracellular region#GO:0005576;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 protein modifying enzyme#PC00260 HUMAN|HGNC=3386|UniProtKB=P29317 P29317 EPHA2 PTHR24416:SF306 TYROSINE-PROTEIN KINASE RECEPTOR EPHRIN TYPE-A RECEPTOR 2 phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein tyrosine kinase activity#GO:0004714;molecular transducer activity#GO:0060089;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888;catalytic activity, acting on a protein#GO:0140096;signaling receptor activity#GO:0038023;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein tyrosine kinase activity#GO:0004713;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 cellular process#GO:0009987;signal transduction#GO:0007165;tube development#GO:0035295;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;cell surface receptor signaling pathway#GO:0007166;developmental process#GO:0032502;vasculature development#GO:0001944;anatomical structure formation involved in morphogenesis#GO:0048646;multicellular organism development#GO:0007275;tube morphogenesis#GO:0035239;cellular response to stimulus#GO:0051716;blood vessel development#GO:0001568;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;blood vessel morphogenesis#GO:0048514;signaling#GO:0023052;regulation of cellular process#GO:0050794;circulatory system development#GO:0072359;response to stimulus#GO:0050896;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;anatomical structure development#GO:0048856;angiogenesis#GO:0001525;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;signaling receptor complex#GO:0043235 transmembrane signal receptor#PC00197 HUMAN|HGNC=20218|UniProtKB=Q8N6I4 Q8N6I4 LYSET PTHR31925:SF1 TRANSMEMBRANE PROTEIN 251 LYSOSOMAL ENZYME TRAFFICKING FACTOR HUMAN|HGNC=16002|UniProtKB=Q8TAP9 Q8TAP9 MPLKIP PTHR22446:SF3 M-PHASE-SPECIFIC PLK1-INTERACTING PROTEIN M-PHASE-SPECIFIC PLK1-INTERACTING PROTEIN nucleus#GO:0005634;microtubule cytoskeleton#GO:0015630;midbody#GO:0030496;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;microtubule organizing center#GO:0005815;centrosome#GO:0005813;cytoskeleton#GO:0005856;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 HUMAN|HGNC=30912|UniProtKB=Q96NZ8 Q96NZ8 WFIKKN1 PTHR45938:SF6 ACP24A4-RELATED WAP, KAZAL, IMMUNOGLOBULIN, KUNITZ AND NTR DOMAIN-CONTAINING PROTEIN 1 binding#GO:0005488;protein binding#GO:0005515;growth factor binding#GO:0019838;molecular function inhibitor activity#GO:0140678;signaling receptor inhibitor activity#GO:0030547;signaling receptor regulator activity#GO:0030545;transforming growth factor beta binding#GO:0050431;molecular function regulator activity#GO:0098772;cytokine binding#GO:0019955 cell surface receptor signaling pathway#GO:0007166;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;biological regulation#GO:0065007;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;signal transduction#GO:0007165;cellular process#GO:0009987;transforming growth factor beta receptor signaling pathway#GO:0007179;cellular response to growth factor stimulus#GO:0071363;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;response to transforming growth factor beta#GO:0071559;signaling#GO:0023052;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;response to growth factor#GO:0070848;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to transforming growth factor beta stimulus#GO:0071560;cellular response to stimulus#GO:0051716;response to endogenous stimulus#GO:0009719 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=11188|UniProtKB=Q07890 Q07890 SOS2 PTHR23113:SF150 GUANINE NUCLEOTIDE EXCHANGE FACTOR SON OF SEVENLESS HOMOLOG 2 molecular function regulator activity#GO:0098772;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;guanyl-nucleotide exchange factor activity#GO:0005085 Ras protein signal transduction#GO:0007265;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 guanyl-nucleotide exchange factor#PC00113 T cell activation#P00053>SOS#P01307;FGF signaling pathway#P00021>SOS#P00641;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>SOS#P00883;PI3 kinase pathway#P00048>SOS#P01185;Interleukin signaling pathway#P00036>SOS#P00981;Ras Pathway#P04393>SOS#P04552;Gonadotropin-releasing hormone receptor pathway#P06664>Sos#P06849;EGF receptor signaling pathway#P00018>SOS#P00558;PDGF signaling pathway#P00047>SOS#P01159;Angiogenesis#P00005>SOS-1#P00193;B cell activation#P00010>SOS#P00379;Integrin signalling pathway#P00034>SOS#P00920 HUMAN|HGNC=15008|UniProtKB=Q8NGZ4 Q8NGZ4 OR2G3 PTHR26453:SF674 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2G3 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;response to stimulus#GO:0050896;response to chemical#GO:0042221;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;detection of chemical stimulus#GO:0009593;system process#GO:0003008;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;nervous system process#GO:0050877;sensory perception#GO:0007600 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=24692|UniProtKB=Q8WWV6 Q8WWV6 FCAMR PTHR11860:SF49 POLYMERIC-IMMUNOGLOBULIN RECEPTOR HIGH AFFINITY IMMUNOGLOBULIN ALPHA AND IMMUNOGLOBULIN MU FC RECEPTOR transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell communication#GO:0007154 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=20239|UniProtKB=Q9H6D8 Q9H6D8 FNDC4 PTHR14470:SF2 FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN 4 regulation of response to stress#GO:0080134;regulation of inflammatory response#GO:0050727;regulation of response to stimulus#GO:0048583;regulation of defense response#GO:0031347;negative regulation of defense response#GO:0031348;regulation of response to external stimulus#GO:0032101;negative regulation of inflammatory response#GO:0050728;negative regulation of response to stimulus#GO:0048585;biological regulation#GO:0065007;negative regulation of response to external stimulus#GO:0032102;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789 membrane#GO:0016020;extracellular region#GO:0005576;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HUMAN|HGNC=9376|UniProtKB=Q13131 Q13131 PRKAA1 PTHR24343:SF306 SERINE/THREONINE KINASE 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1 protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824 cellular response to starvation#GO:0009267;negative regulation of cellular process#GO:0048523;cellular response to nutrient levels#GO:0031669;regulation of response to stimulus#GO:0048583;positive regulation of catabolic process#GO:0009896;regulation of TORC1 signaling#GO:1903432;intracellular protein localization#GO:0008104;regulation of catabolic process#GO:0009894;macromolecule localization#GO:0033036;response to nutrient levels#GO:0031667;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;cellular response to glucose starvation#GO:0042149;negative regulation of response to stimulus#GO:0048585;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;localization#GO:0051179;response to starvation#GO:0042594;cellular response to stimulus#GO:0051716;negative regulation of TOR signaling#GO:0032007;regulation of cellular process#GO:0050794;protein localization to organelle#GO:0033365;regulation of cell communication#GO:0010646;negative regulation of TORC1 signaling#GO:1904262;positive regulation of autophagy#GO:0010508;response to stress#GO:0006950;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of TOR signaling#GO:0032006;negative regulation of signal transduction#GO:0009968;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;cellular response to stress#GO:0033554;regulation of signaling#GO:0023051;positive regulation of metabolic process#GO:0009893;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;regulation of autophagy#GO:0010506;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;response to stimulus#GO:0050896 transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;protein kinase complex#GO:1902911;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 Gonadotropin-releasing hormone receptor pathway#P06664>AMPK#P06830;p53 pathway by glucose deprivation#P04397>AMPK#P04639 HUMAN|HGNC=1989|UniProtKB=Q99426 Q99426 TBCB PTHR18916:SF97 DYNACTIN 1-RELATED MICROTUBULE-BINDING TUBULIN-FOLDING COFACTOR B protein binding#GO:0005515;microtubule binding#GO:0008017;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631 cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226;supramolecular fiber organization#GO:0097435;microtubule-based process#GO:0007017;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;cytoplasmic microtubule organization#GO:0031122;cytoskeleton organization#GO:0007010 supramolecular fiber#GO:0099512;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell cortex#GO:0005938;microtubule end#GO:1990752;microtubule plus-end#GO:0035371;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;nucleus#GO:0005634;cell periphery#GO:0071944;microtubule cytoskeleton#GO:0015630 chaperone#PC00072 HUMAN|HGNC=20147|UniProtKB=Q7L1T6 Q7L1T6 CYB5R4 PTHR46237:SF2 CYTOCHROME B5 REDUCTASE 4 FAMILY MEMBER CYTOCHROME B5 REDUCTASE 4 oxidoreductase activity, acting on NAD(P)H#GO:0016651;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 superoxide metabolic process#GO:0006801;cellular process#GO:0009987;reactive oxygen species metabolic process#GO:0072593;metabolic process#GO:0008152 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 reductase#PC00198 HUMAN|HGNC=33757|UniProtKB=Q6QAJ8 Q6QAJ8 TMEM220 PTHR34262:SF1 TRANSMEMBRANE PROTEIN 220 TRANSMEMBRANE PROTEIN 220 HUMAN|HGNC=12177|UniProtKB=A0A0K0K1A3 A0A0K0K1A3 TRBV10-1 PTHR23268:SF42 T-CELL RECEPTOR BETA CHAIN T CELL RECEPTOR BETA VARIABLE 10-1-RELATED cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=14881|UniProtKB=O60315 O60315 ZEB2 PTHR24391:SF11 HISTONE H4 TRANSCRIPTION FACTOR-RELATED ZINC FINGER E-BOX-BINDING HOMEOBOX 2 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;central nervous system development#GO:0007417;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;nervous system development#GO:0007399;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biosynthetic process#GO:0009889;multicellular organism development#GO:0007275;regulation of gene expression#GO:0010468;developmental process#GO:0032502 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=23032|UniProtKB=Q96HR3 Q96HR3 MED30 PTHR31705:SF4 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 30 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 30 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;mediator complex#GO:0016592;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 general transcription factor#PC00259 HUMAN|HGNC=30263|UniProtKB=Q9P2J9 Q9P2J9 PDP2 PTHR13832:SF343 PROTEIN PHOSPHATASE 2C [PYRUVATE DEHYDROGENASE [ACETYL-TRANSFERRING]]-PHOSPHATASE 2, MITOCHONDRIAL hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;phosphoprotein phosphatase activity#GO:0004721;protein serine/threonine phosphatase activity#GO:0004722;hydrolase activity#GO:0016787 cell communication#GO:0007154;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739 protein phosphatase#PC00195 HUMAN|HGNC=18071|UniProtKB=Q7Z589 Q7Z589 EMSY PTHR16500:SF3 BRCA2-INTERACTING TRANSCRIPTIONAL REPRESSOR EMSY BRCA2-INTERACTING TRANSCRIPTIONAL REPRESSOR EMSY membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 HUMAN|HGNC=19342|UniProtKB=Q9BVH7 Q9BVH7 ST6GALNAC5 PTHR45906:SF5 ALPHA-N-ACETYL-NEURAMINYL-2,3-BETA-GALACTOSYL-1, 3-N-ACETYL-GALACTOSAMINIDE ALPHA-2,6-SIALYLTRANSFERASE-LIKE ALPHA-N-ACETYLGALACTOSAMINIDE ALPHA-2,6-SIALYLTRANSFERASE 5 glycosyltransferase activity#GO:0016757;sialyltransferase activity#GO:0008373;catalytic activity#GO:0003824;transferase activity#GO:0016740 ceramide metabolic process#GO:0006672;glycolipid biosynthetic process#GO:0009247;glycosphingolipid biosynthetic process#GO:0006688;glycolipid metabolic process#GO:0006664;liposaccharide metabolic process#GO:1903509;carbohydrate metabolic process#GO:0005975;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;oligosaccharide metabolic process#GO:0009311;sphingolipid biosynthetic process#GO:0030148;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;ceramide biosynthetic process#GO:0046513;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135 HUMAN|HGNC=9138|UniProtKB=Q01780 Q01780 EXOSC10 PTHR12124:SF47 POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED EXOSOME COMPLEX COMPONENT 10 HUMAN|HGNC=581|UniProtKB=O00213 O00213 APBB1 PTHR14058:SF5 AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B AMYLOID BETA PRECURSOR PROTEIN BINDING FAMILY B MEMBER 1 peptide binding#GO:0042277;binding#GO:0005488 DNA damage response#GO:0006974;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;response to stress#GO:0006950;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular response to stress#GO:0033554;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;regulation of macromolecule metabolic process#GO:0060255;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 Alzheimer disease-presenilin pathway#P00004>Fe65#P00126;Alzheimer disease-amyloid secretase pathway#P00003>Fe65#P00087 HUMAN|HGNC=17563|UniProtKB=Q86U44 Q86U44 METTL3 PTHR12829:SF7 N6-ADENOSINE-METHYLTRANSFERASE N(6)-ADENOSINE-METHYLTRANSFERASE CATALYTIC SUBUNIT METTL3 methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;RNA methyltransferase activity#GO:0008173;catalytic activity, acting on RNA#GO:0140098;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a nucleic acid#GO:0140640 macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;RNA modification#GO:0009451;mRNA metabolic process#GO:0016071;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA modification#GO:0016556;cellular process#GO:0009987 transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;methyltransferase complex#GO:0034708;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 RNA methyltransferase#PC00033 HUMAN|HGNC=16155|UniProtKB=Q9BR11 Q9BR11 ZSWIM1 PTHR31569:SF0 SWIM-TYPE DOMAIN-CONTAINING PROTEIN ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 1 HUMAN|HGNC=19136|UniProtKB=Q64ET8 Q64ET8 FRG2 PTHR31883:SF7 PROTEIN FRG2-RELATED PROTEIN FRG2-RELATED HUMAN|HGNC=17292|UniProtKB=Q8IWA5 Q8IWA5 SLC44A2 PTHR12385:SF34 CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44) CHOLINE TRANSPORTER-LIKE PROTEIN 2 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 transport#GO:0006810;cellular process#GO:0009987;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179 membrane#GO:0016020;cellular anatomical structure#GO:0110165 transporter#PC00227;secondary carrier transporter#PC00258 HUMAN|HGNC=4979|UniProtKB=P50219 P50219 MNX1 PTHR24335:SF3 MOTOR NEURON AND PANCREAS HOMEOBOX PROTEIN MOTOR NEURON AND PANCREAS HOMEOBOX PROTEIN 1 double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulator activity#GO:0140110;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 system development#GO:0048731;cell fate commitment#GO:0045165;anatomical structure development#GO:0048856;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cell differentiation#GO:0030154;central nervous system development#GO:0007417;pancreas development#GO:0031016;neurogenesis#GO:0022008;multicellular organism development#GO:0007275;animal organ development#GO:0048513;cellular developmental process#GO:0048869;developmental process#GO:0032502;neuron differentiation#GO:0030182;central nervous system neuron differentiation#GO:0021953;cell fate specification#GO:0001708;nervous system development#GO:0007399;epithelium development#GO:0060429;multicellular organismal process#GO:0032501;epithelial cell differentiation#GO:0030855;tissue development#GO:0009888;cellular process#GO:0009987;neuron fate commitment#GO:0048663 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 HUMAN|HGNC=30940|UniProtKB=Q9HCE3 Q9HCE3 ZNF532 PTHR47222:SF3 ZINC FINGER PROTEIN 532-RELATED ZINC FINGER PROTEIN 532 HUMAN|HGNC=25539|UniProtKB=Q6PCD5 Q6PCD5 RFWD3 PTHR16047:SF7 RFWD3 PROTEIN E3 UBIQUITIN-PROTEIN LIGASE RFWD3 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=23513|UniProtKB=Q70EL1 Q70EL1 USP54 PTHR22975:SF5 UBIQUITIN SPECIFIC PROTEINASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 54 cysteine protease#PC00081;protein modifying enzyme#PC00260;protease#PC00190 HUMAN|HGNC=11814|UniProtKB=P62072 P62072 TIMM10 PTHR11038:SF16 MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10 MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10 molecular carrier activity#GO:0140104;protein carrier activity#GO:0140597 membrane organization#GO:0061024;protein insertion into mitochondrial inner membrane#GO:0045039;mitochondrial protein import pathway#GO:7770058;mitochondrion organization#GO:0007005;organelle organization#GO:0006996;inner mitochondrial membrane organization#GO:0007007;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;mitochondrial membrane organization#GO:0007006;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;intracellular transport#GO:0046907;transport#GO:0006810;mitochondrial transport#GO:0006839;cellular component organization#GO:0016043;cellular localization#GO:0051641;localization#GO:0051179 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;TIM22 mitochondrial import inner membrane insertion complex#GO:0042721;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;membrane protein complex#GO:0098796;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;inner mitochondrial membrane protein complex#GO:0098800;organelle membrane#GO:0031090;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798 transporter#PC00227 HUMAN|HGNC=25699|UniProtKB=Q9HA65 Q9HA65 TBC1D17 PTHR22957:SF360 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN TBC1 DOMAIN FAMILY MEMBER 17 enzyme regulator activity#GO:0030234;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047 retrograde transport, endosome to Golgi#GO:0042147;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;cytosolic transport#GO:0016482;intracellular transport#GO:0046907;transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;endosomal transport#GO:0016197 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 GTPase-activating protein#PC00257;protein-binding activity modulator#PC00095;G-protein modulator#PC00022 HUMAN|HGNC=25701|UniProtKB=Q3L8U1 Q3L8U1 CHD9 PTHR46850:SF1 CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 9 ATP-DEPENDENT CHROMATIN REMODELER CHD9 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=44440|UniProtKB=C9JPN9 C9JPN9 USP17L12 PTHR24006:SF651 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE INACTIVE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 17-LIKE PROTEIN 4-RELATED catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;cysteine-type deubiquitinase activity#GO:0004843;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005 regulation of programmed cell death#GO:0043067;regulation of apoptotic process#GO:0042981;regulation of protein stability#GO:0031647;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of biological quality#GO:0065008;biological regulation#GO:0065007 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 cysteine protease#PC00081;protease#PC00190 HUMAN|HGNC=17699|UniProtKB=Q52WX2 Q52WX2 SBK1 PTHR24359:SF0 SERINE/THREONINE-PROTEIN KINASE SBK1 SERINE_THREONINE-PROTEIN KINASE SBK1 catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=28381|UniProtKB=Q8NHP6 Q8NHP6 MOSPD2 PTHR46384:SF1 MOTILE SPERM DOMAIN-CONTAINING PROTEIN 2 MOTILE SPERM DOMAIN-CONTAINING PROTEIN 2 organelle membrane contact site#GO:0044232;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=14745|UniProtKB=Q8NGD3 Q8NGD3 OR4K5 PTHR48002:SF56 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 4K5 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=27351|UniProtKB=Q8WVE0 Q8WVE0 EEF1AKMT1 PTHR13200:SF0 EEF1A LYSINE METHYLTRANSFERASE 1 EEF1A LYSINE METHYLTRANSFERASE 1 catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741;protein methyltransferase activity#GO:0008276;lysine N-methyltransferase activity#GO:0016278;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;protein-lysine N-methyltransferase activity#GO:0016279;N-methyltransferase activity#GO:0008170 HUMAN|HGNC=16889|UniProtKB=O00487 O00487 PSMD14 PTHR10410:SF5 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED UBIQUITIN C-TERMINAL HYDROLASE PSMD14 catalytic activity#GO:0003824;deubiquitinase activity#GO:0101005;metallopeptidase activity#GO:0008237;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233 primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;endopeptidase complex#GO:1905369;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;proteasome regulatory particle, lid subcomplex#GO:0008541;peptidase complex#GO:1905368;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;proteasome complex#GO:0000502 translation initiation factor#PC00224;translation factor#PC00223 Ubiquitin proteasome pathway#P00060>26S proteasome#P01489;Cell cycle#P00013>Proteasome#P00480 HUMAN|HGNC=6731|UniProtKB=O76036 O76036 NCR1 PTHR11738:SF14 MHC CLASS I NK CELL RECEPTOR NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 1 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;immune receptor activity#GO:0140375;molecular transducer activity#GO:0060089 response to stimulus#GO:0050896;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;signaling#GO:0023052;immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;immune response-regulating signaling pathway#GO:0002764;cellular process#GO:0009987;cell communication#GO:0007154;regulation of immune response#GO:0050776;regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=24362|UniProtKB=C4AMC7 C4AMC7 WASH3P PTHR23331:SF5 CXYORF1 WAS PROTEIN FAMILY HOMOLOG 2-RELATED cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;endosomal transport#GO:0016197;exocytosis#GO:0006887;actin filament organization#GO:0007015;vesicle-mediated transport to the plasma membrane#GO:0098876;intracellular transport#GO:0046907;transport#GO:0006810;vesicle-mediated transport#GO:0016192;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;retrograde transport, endosome to Golgi#GO:0042147;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;Arp2/3 complex-mediated actin nucleation#GO:0034314;localization#GO:0051179;secretion#GO:0046903;cellular localization#GO:0051641;secretion by cell#GO:0032940;supramolecular fiber organization#GO:0097435;localization within membrane#GO:0051668;actin filament-based process#GO:0030029;endocytic recycling#GO:0032456;actin cytoskeleton organization#GO:0030036;actin nucleation#GO:0045010;export from cell#GO:0140352;cytosolic transport#GO:0016482;cellular component organization#GO:0016043 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;recycling endosome#GO:0055037;intracellular organelle#GO:0043229;endosome#GO:0005768 membrane traffic protein#PC00150 HUMAN|HGNC=34434|UniProtKB=Q6R6M4 Q6R6M4 USP17L2 PTHR24006:SF651 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE INACTIVE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 17-LIKE PROTEIN 4-RELATED deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787;cysteine-type deubiquitinase activity#GO:0004843;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783 regulation of protein stability#GO:0031647;regulation of biological process#GO:0050789;regulation of apoptotic process#GO:0042981;regulation of programmed cell death#GO:0043067;biological regulation#GO:0065007;regulation of biological quality#GO:0065008;regulation of cellular process#GO:0050794 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cytosol#GO:0005829;nucleus#GO:0005634 protease#PC00190;cysteine protease#PC00081 HUMAN|HGNC=17359|UniProtKB=Q7Z3B4 Q7Z3B4 NUP54 PTHR13000:SF0 NUCLEOPORIN P54 NUCLEOPORIN P54 structural constituent of nuclear pore#GO:0017056;structural molecule activity#GO:0005198 localization within membrane#GO:0051668;nucleocytoplasmic transport#GO:0006913;localization#GO:0051179;NLS-bearing protein import into nucleus#GO:0006607;cellular localization#GO:0051641;nuclear pore organization#GO:0006999;nuclear transport#GO:0051169;protein transport#GO:0015031;protein import into nucleus#GO:0006606;protein localization to membrane#GO:0072657;cellular component organization#GO:0016043;protein localization to organelle#GO:0033365;intracellular transport#GO:0046907;transport#GO:0006810;intracellular protein transport#GO:0006886;cellular component organization or biogenesis#GO:0071840;establishment of protein localization to organelle#GO:0072594;nucleus organization#GO:0006997;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;protein-containing complex organization#GO:0043933;macromolecule localization#GO:0033036;import into nucleus#GO:0051170;organelle organization#GO:0006996;protein localization to nucleus#GO:0034504;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987 intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;nuclear pore#GO:0005643;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle envelope#GO:0031967;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635 transporter#PC00227 HUMAN|HGNC=25085|UniProtKB=Q5XKR9 Q5XKR9 VCF2 PTHR34763:SF2 PROTEIN FAM104A PROTEIN VCF2 HUMAN|HGNC=10426|UniProtKB=P46782 P46782 RPS5 PTHR11205:SF34 RIBOSOMAL PROTEIN S7 SMALL RIBOSOMAL SUBUNIT PROTEIN US7 mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488;rRNA binding#GO:0019843;structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198;RNA binding#GO:0003723 translation#GO:0006412;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein biosynthetic process#GO:0160307 ribosome#GO:0005840;cytosol#GO:0005829;cytosolic ribosome#GO:0022626;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;small ribosomal subunit#GO:0015935;cytosolic small ribosomal subunit#GO:0022627;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 translational protein#PC00263;ribosomal protein#PC00202 HUMAN|HGNC=12028|UniProtKB=P14625 P14625 HSP90B1 PTHR11528:SF96 HEAT SHOCK PROTEIN 90 FAMILY MEMBER ENDOPLASMIN nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP binding#GO:0005524;binding#GO:0005488;ATP-dependent activity#GO:0140657;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824 protein maturation#GO:0051604;gene expression#GO:0010467;response to chemical#GO:0042221;proteasomal protein catabolic process#GO:0010498;biosynthetic process#GO:0009058;response to stress#GO:0006950;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;response to stimulus#GO:0050896;catabolic process#GO:0009056;protein folding#GO:0006457;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;protein metabolic process#GO:0019538;ERAD pathway#GO:0036503;response to endoplasmic reticulum stress#GO:0034976;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;perinuclear region of cytoplasm#GO:0048471;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 Hsp90 family chaperone#PC00028;chaperone#PC00072 HUMAN|HGNC=37233|UniProtKB=A8MRT5 A8MRT5 NPIPB5 PTHR15438:SF5 NUCLEAR PORE COMPLEX INTERACTING PROTEIN NUCLEAR PORE COMPLEX INTERACTING PROTEIN FAMILY MEMBER B3-RELATED HUMAN|HGNC=2208|UniProtKB=Q14031 Q14031 COL4A6 PTHR24023:SF533 COLLAGEN ALPHA COLLAGEN ALPHA-6(IV) CHAIN structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;extracellular structure organization#GO:0043062;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;cellular component organization or biogenesis#GO:0071840;cell surface receptor signaling pathway#GO:0007166 external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;basement membrane#GO:0005604;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 extracellular matrix structural protein#PC00103;extracellular matrix protein#PC00102 Integrin signalling pathway#P00034>Collagen#P00922 HUMAN|HGNC=16658|UniProtKB=Q96BY2 Q96BY2 MOAP1 PTHR23095:SF14 PARANEOPLASTIC ANTIGEN MODULATOR OF APOPTOSIS 1 regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of programmed cell death#GO:0043067;regulation of biological process#GO:0050789;regulation of apoptotic process#GO:0042981 transcription cofactor#PC00217 HUMAN|HGNC=6887|UniProtKB=P49137 P49137 MAPKAPK2 PTHR24349:SF63 SERINE/THREONINE-PROTEIN KINASE MAP KINASE-ACTIVATED PROTEIN KINASE 2 kinase activity#GO:0016301;calmodulin binding#GO:0005516;transferase activity#GO:0016740;mitogen-activated protein kinase binding#GO:0051019;protein kinase binding#GO:0019901;calcium/calmodulin-dependent protein kinase activity#GO:0004683;enzyme binding#GO:0019899;protein serine/threonine kinase activity#GO:0004674;binding#GO:0005488;kinase binding#GO:0019900;protein kinase activity#GO:0004672;protein binding#GO:0005515;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 positive regulation of defense response#GO:0031349;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;regulation of response to stress#GO:0080134;positive regulation of response to biotic stimulus#GO:0002833;pattern recognition receptor signaling pathway#GO:0002221;defense response#GO:0006952;regulation of innate immune response#GO:0045088;positive regulation of innate immune response#GO:0045089;activation of innate immune response#GO:0002218;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;inflammatory response#GO:0006954;regulation of immune response#GO:0050776;regulation of defense response#GO:0031347;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;cellular response to stimulus#GO:0051716;innate immune response-activating signaling pathway#GO:0002758;regulation of response to biotic stimulus#GO:0002831;response to growth factor#GO:0070848;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;immune response-activating signaling pathway#GO:0002757;positive regulation of response to external stimulus#GO:0032103;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;signal transduction#GO:0007165;cellular process#GO:0009987;response to stress#GO:0006950;positive regulation of immune system process#GO:0002684;response to chemical#GO:0042221;response to cytokine#GO:0034097;regulation of response to external stimulus#GO:0032101;immune system process#GO:0002376;cellular response to growth factor stimulus#GO:0071363;response to peptide#GO:1901652;regulation of biological process#GO:0050789;immune response-regulating signaling pathway#GO:0002764;toll-like receptor signaling pathway#GO:0002224;response to endogenous stimulus#GO:0009719;vascular endothelial growth factor receptor signaling pathway#GO:0048010;signaling#GO:0023052;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Angiogenesis#P00005>MAPKAPK2/3#P00244;p38 MAPK pathway#P05918>MAPKAP-K2#P05920;Interleukin signaling pathway#P00036>MAPKAPK2#P00979;Ras Pathway#P04393>MAPKAP#P04564;PDGF signaling pathway#P00047>MAPKAPK2#P01157;VEGF signaling pathway#P00056>MAPKAPK2/3#P01415 HUMAN|HGNC=11603|UniProtKB=P57082 P57082 TBX4 PTHR11267:SF29 T-BOX PROTEIN-RELATED T-BOX TRANSCRIPTION FACTOR TBX4 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;tube development#GO:0035295;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;tube morphogenesis#GO:0035239;blood vessel development#GO:0001568;vasculature development#GO:0001944;anatomical structure formation involved in morphogenesis#GO:0048646;multicellular organism development#GO:0007275;cell fate specification#GO:0001708;cellular process#GO:0009987;cell fate commitment#GO:0045165;angiogenesis#GO:0001525;animal gross anatomical part developmental process#GO:0160108;circulatory system development#GO:0072359;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;blood vessel morphogenesis#GO:0048514 chromosome#GO:0005694;chromatin#GO:0000785;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 Rel homology transcription factor#PC00252;immunoglobulin fold transcription factor#PC00251 HUMAN|HGNC=15827|UniProtKB=Q9UKG4 Q9UKG4 SLC13A4 PTHR10283:SF63 SOLUTE CARRIER FAMILY 13 MEMBER SOLUTE CARRIER FAMILY 13 MEMBER 4 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;cellular process#GO:0009987;transport#GO:0006810 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 secondary carrier transporter#PC00258;transporter#PC00227 HUMAN|HGNC=28615|UniProtKB=Q5H9R4 Q5H9R4 ARMCX4 PTHR47081:SF1 FAMILY NOT NAMED ARMADILLO REPEAT-CONTAINING X-LINKED PROTEIN 4 HUMAN|HGNC=10906|UniProtKB=Q12908 Q12908 SLC10A2 PTHR10361:SF19 SODIUM-BILE ACID COTRANSPORTER ILEAL SODIUM_BILE ACID COTRANSPORTER bile acid transmembrane transporter activity#GO:0015125;monoatomic cation transmembrane transporter activity#GO:0008324;solute:sodium symporter activity#GO:0015370;symporter activity#GO:0015293;carboxylic acid transmembrane transporter activity#GO:0046943;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;solute:monoatomic cation symporter activity#GO:0015294;monoatomic ion transmembrane transporter activity#GO:0015075;secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 monocarboxylic acid transport#GO:0015718;organic hydroxy compound transport#GO:0015850;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810;organic acid transport#GO:0015849;carboxylic acid transport#GO:0046942;bile acid and bile salt transport#GO:0015721;lipid localization#GO:0010876;lipid transport#GO:0006869;macromolecule localization#GO:0033036 membrane#GO:0016020;apical plasma membrane#GO:0016324;cell periphery#GO:0071944;apical part of cell#GO:0045177;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;plasma membrane#GO:0005886 primary active transporter#PC00068 HUMAN|HGNC=6180|UniProtKB=Q14643 Q14643 ITPR1 PTHR13715:SF52 RYANODINE RECEPTOR AND IP3 RECEPTOR INOSITOL 1,4,5-TRISPHOSPHATE-GATED CALCIUM CHANNEL ITPR1 alcohol binding#GO:0043178;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;ligand-gated calcium channel activity#GO:0099604;metal ion binding#GO:0046872;gated channel activity#GO:0022836;calcium ion binding#GO:0005509;binding#GO:0005488;monoatomic cation channel activity#GO:0005261;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;phosphatidylinositol binding#GO:0035091;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;channel activity#GO:0015267;cation binding#GO:0043169;ligand-gated monoatomic ion channel activity#GO:0015276;anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167 cellular process#GO:0009987;release of sequestered calcium ion into cytosol#GO:0051209;signal transduction#GO:0007165;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transmembrane transport#GO:0098655;transport#GO:0006810;calcium ion transport#GO:0006816;establishment of localization#GO:0051234;calcium ion transmembrane import into cytosol#GO:0097553;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;calcium ion transmembrane transport#GO:0070588;metal ion transport#GO:0030001;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;phospholipase C-activating G protein-coupled receptor signaling pathway#GO:0007200;G protein-coupled receptor signaling pathway#GO:0007186;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;cell communication#GO:0007154;localization#GO:0051179 intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;sarcoplasm#GO:0016528;secretory granule#GO:0030141;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;vesicle#GO:0031982;intracellular vesicle#GO:0097708;secretory granule membrane#GO:0030667;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;sarcoplasmic reticulum#GO:0016529;cell periphery#GO:0071944;vesicle membrane#GO:0012506;membrane#GO:0016020;secretory vesicle#GO:0099503;plasma membrane#GO:0005886;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659 ligand-gated ion channel#PC00141;ion channel#PC00133 Histamine H1 receptor mediated signaling pathway#P04385>IP3R#P04486;Metabotropic glutamate receptor group I pathway#P00041>IP3R#P01056;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>IP3R#P00842;Endothelin signaling pathway#P00019>IP3 R#P00590;Alpha adrenergic receptor signaling pathway#P00002>IP3R#P00076;B cell activation#P00010>IP3R#P00398;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>IP3 channel#P00735;PDGF signaling pathway#P00047>IP3 receptor#P01160;Gonadotropin-releasing hormone receptor pathway#P06664>IP3R#P06768;Angiotensin II-stimulated signaling through G proteins and beta-arrestin#P05911>IP3R#P05932;Wnt signaling pathway#P00057>IP3 Gated Calcium Channel#P01426;T cell activation#P00053>IP3R#P01331;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>IP3R#P01064;CCKR signaling map#P06959>IP3R#P07123 HUMAN|HGNC=11022|UniProtKB=P78381 P78381 SLC35A2 PTHR10231:SF106 NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER UDP-GALACTOSE TRANSLOCATOR transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;nucleotide-sugar transmembrane transporter activity#GO:0005338;carbohydrate derivative transmembrane transporter activity#GO:1901505;nucleobase-containing compound transmembrane transporter activity#GO:0015932;organophosphate ester transmembrane transporter activity#GO:0015605;UDP-galactose transmembrane transporter activity#GO:0005459 transport#GO:0006810;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;cellular process#GO:0009987;carbohydrate derivative transport#GO:1901264;nucleotide-sugar transmembrane transport#GO:0015780;nitrogen compound transport#GO:0071705;nucleobase-containing compound transport#GO:0015931;organophosphate ester transport#GO:0015748 membrane-bounded organelle#GO:0043227;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020 transporter#PC00227 HUMAN|HGNC=4846|UniProtKB=Q9UL51 Q9UL51 HCN2 PTHR45689:SF11 I[[H]] CHANNEL, ISOFORM E POTASSIUM_SODIUM HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNEL 2 potassium channel activity#GO:0005267;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;transporter activity#GO:0005215;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216 regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;transport#GO:0006810;potassium ion transport#GO:0006813;potassium ion transmembrane transport#GO:0071805;biological regulation#GO:0065007;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;regulation of cellular process#GO:0050794;metal ion transport#GO:0030001;regulation of biological process#GO:0050789;sodium ion transport#GO:0006814 membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;transporter complex#GO:1990351;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;dendrite#GO:0030425;axon#GO:0030424;dendritic tree#GO:0097447;transmembrane transporter complex#GO:1902495 transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=14561|UniProtKB=O43307 O43307 ARHGEF9 PTHR45834:SF6 RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 9-RELATED RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 9 guanyl-nucleotide exchange factor activity#GO:0005085;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 regulation of organelle assembly#GO:1902115;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;biological regulation#GO:0065007;regulation of cellular component biogenesis#GO:0044087;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794 intracellular anatomical structure#GO:0005622;cell junction#GO:0030054;GABA-ergic synapse#GO:0098982;cytoplasm#GO:0005737;postsynaptic specialization#GO:0099572;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cytosol#GO:0005829;postsynapse#GO:0098794 guanyl-nucleotide exchange factor#PC00113;protein-binding activity modulator#PC00095;G-protein modulator#PC00022 HUMAN|HGNC=1787|UniProtKB=P42771 P42771 CDKN2A PTHR24201:SF4 ANK_REP_REGION DOMAIN-CONTAINING PROTEIN CYCLIN-DEPENDENT KINASE INHIBITOR 2A cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538;enzyme inhibitor activity#GO:0004857;kinase inhibitor activity#GO:0019210;cyclin-dependent protein serine/threonine kinase inhibitor activity#GO:0004861;protein kinase inhibitor activity#GO:0004860;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;cyclin-dependent protein kinase regulator activity#GO:0019914;protein kinase regulator activity#GO:0019887;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678 regulation of cell population proliferation#GO:0042127;regulation of mitotic cell cycle phase transition#GO:1901990;regulation of G1/S transition of mitotic cell cycle#GO:2000045;negative regulation of cellular process#GO:0048523;regulation of cell cycle process#GO:0010564;regulation of cell cycle#GO:0051726;biological regulation#GO:0065007;regulation of cell cycle G1/S phase transition#GO:1902806;regulation of cellular process#GO:0050794;regulation of mitotic cell cycle#GO:0007346;regulation of biological process#GO:0050789;negative regulation of cell population proliferation#GO:0008285;negative regulation of biological process#GO:0048519;regulation of cell cycle phase transition#GO:1901987 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 kinase inhibitor#PC00139;protein-binding activity modulator#PC00095 p53 pathway#P00059>ARF#P01482;p53 pathway#P00059>ARF#G01574 HUMAN|HGNC=9258|UniProtKB=Q9UNP9 Q9UNP9 PPIE PTHR11071:SF593 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE E ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;nuclear protein-containing complex#GO:0140513;catalytic step 2 spliceosome#GO:0071013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;spliceosomal complex#GO:0005681;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231 chaperone#PC00072 HUMAN|HGNC=1633|UniProtKB=P15391 P15391 CD19 PTHR16674:SF2 B-LYMPHOCYTE ANTIGEN CD19 B-LYMPHOCYTE ANTIGEN CD19 signaling adaptor activity#GO:0035591;signaling receptor complex adaptor activity#GO:0030159;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 cell communication#GO:0007154;immune system process#GO:0002376;regulation of immune response#GO:0050776;response to stimulus#GO:0050896;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;signaling#GO:0023052;immune response-activating cell surface receptor signaling pathway#GO:0002429;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;immune response-regulating signaling pathway#GO:0002764;immune response-activating signaling pathway#GO:0002757;positive regulation of immune response#GO:0050778;cell surface receptor signaling pathway#GO:0007166;regulation of response to stimulus#GO:0048583;antigen receptor-mediated signaling pathway#GO:0050851;positive regulation of response to stimulus#GO:0048584;immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007;positive regulation of immune system process#GO:0002684;signal transduction#GO:0007165;activation of immune response#GO:0002253;positive regulation of biological process#GO:0048518;B cell receptor signaling pathway#GO:0050853;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 B cell activation#P00010>CD19#P00393 HUMAN|HGNC=34246|UniProtKB=A6NJL1 A6NJL1 ZSCAN5B PTHR23226:SF306 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 5B sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987 regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=1733|UniProtKB=Q14004 Q14004 CDK13 PTHR24056:SF459 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE 13 protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096 regulation of biological process#GO:0050789;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of DNA-templated transcription, elongation#GO:0032786;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription elongation by RNA polymerase II#GO:0034243;regulation of DNA-templated transcription elongation#GO:0032784;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;transcription elongation factor complex#GO:0008023;intracellular membrane-bounded organelle#GO:0043231;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;protein kinase complex#GO:1902911;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;cyclin-dependent protein kinase holoenzyme complex#GO:0000307 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=6008|UniProtKB=P01589 P01589 IL2RA PTHR10573:SF0 INTERLEUKIN-2 RECEPTOR ALPHA CHAIN INTERLEUKIN-2 RECEPTOR SUBUNIT ALPHA signaling receptor activity#GO:0038023;immune receptor activity#GO:0140375;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;cytokine receptor activity#GO:0004896 positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;positive regulation of cell-cell adhesion#GO:0022409;positive regulation of immune system process#GO:0002684;regulation of mononuclear cell proliferation#GO:0032944;regulation of multicellular organismal process#GO:0051239;positive regulation of T cell activation#GO:0050870;response to chemical#GO:0042221;response to cytokine#GO:0034097;regulation of T cell activation#GO:0050863;positive regulation of leukocyte activation#GO:0002696;cell surface receptor signaling pathway#GO:0007166;regulation of leukocyte proliferation#GO:0070663;positive regulation of mononuclear cell proliferation#GO:0032946;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;regulation of cell activation#GO:0050865;positive regulation of multicellular organismal process#GO:0051240;regulation of leukocyte activation#GO:0002694;positive regulation of cell population proliferation#GO:0008284;positive regulation of T cell proliferation#GO:0042102;signaling#GO:0023052;regulation of lymphocyte activation#GO:0051249;response to stimulus#GO:0050896;response to peptide#GO:1901652;positive regulation of cellular process#GO:0048522;biological regulation#GO:0065007;positive regulation of leukocyte cell-cell adhesion#GO:1903039;positive regulation of cell activation#GO:0050867;regulation of cell adhesion#GO:0030155;regulation of lymphocyte proliferation#GO:0050670;regulation of leukocyte cell-cell adhesion#GO:1903037;positive regulation of leukocyte proliferation#GO:0070665;interleukin-2-mediated signaling pathway#GO:0038110;cellular response to stimulus#GO:0051716;positive regulation of cell adhesion#GO:0045785;regulation of T cell proliferation#GO:0042129;regulation of cell-cell adhesion#GO:0022407;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;positive regulation of lymphocyte proliferation#GO:0050671;cytokine-mediated signaling pathway#GO:0019221;positive regulation of lymphocyte activation#GO:0051251;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127 plasma membrane#GO:0005886;cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020 transmembrane signal receptor#PC00197 Interleukin signaling pathway#P00036>Receptor subunit alpha#P00992 HUMAN|HGNC=29322|UniProtKB=Q9HCG8 Q9HCG8 CWC22 PTHR18034:SF3 CELL CYCLE CONTROL PROTEIN CWF22-RELATED PRE-MRNA-SPLICING FACTOR CWC22 HOMOLOG RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA splicing, via spliceosome#GO:0000398;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;mRNA cis splicing, via spliceosome#GO:0045292 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;catalytic step 2 spliceosome#GO:0071013;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;spliceosomal complex#GO:0005681;U2-type spliceosomal complex#GO:0005684;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226 RNA processing factor#PC00147 HUMAN|HGNC=17788|UniProtKB=Q9HAP6 Q9HAP6 LIN7B PTHR14063:SF7 PROTEIN LIN-7 HOMOLOG PROTEIN LIN-7 HOMOLOG B molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 regulation of synapse assembly#GO:0051963;neurotransmitter secretion#GO:0007269;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;vesicle localization#GO:0051648;establishment of localization#GO:0051234;transport#GO:0006810;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;regulation of developmental process#GO:0050793;signal release from synapse#GO:0099643;chemical synaptic transmission#GO:0007268;regulation of growth#GO:0040008;regulation of synapse structure or activity#GO:0050803;secretion#GO:0046903;cell communication#GO:0007154;localization#GO:0051179;trans-synaptic signaling#GO:0099537;organelle localization#GO:0051640;signal release#GO:0023061;regulation of cell junction assembly#GO:1901888;synaptic vesicle localization#GO:0097479;neurotransmitter transport#GO:0006836;establishment of vesicle localization#GO:0051650;synaptic signaling#GO:0099536;synaptic vesicle transport#GO:0048489;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of organelle localization#GO:0051656;regulation of cellular component organization#GO:0051128;regulation of cellular component biogenesis#GO:0044087;signaling#GO:0023052;export from cell#GO:0140352;regulation of biological process#GO:0050789;cellular localization#GO:0051641;regulation of biological quality#GO:0065008;secretion by cell#GO:0032940;regulation of synapse organization#GO:0050807 cellular anatomical structure#GO:0110165;synapse#GO:0045202;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane protein complex#GO:0098796;membrane#GO:0016020;cell-cell junction#GO:0005911;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;cell junction#GO:0030054;adherens junction#GO:0005912;anchoring junction#GO:0070161 cell junction protein#PC00070 HUMAN|HGNC=29506|UniProtKB=Q9C0H9 Q9C0H9 SRCIN1 PTHR22741:SF5 P140CAP/SNIP-RELATED SRC KINASE SIGNALING INHIBITOR 1 regulation of postsynapse organization#GO:0099175;regulation of neuron projection development#GO:0010975;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of developmental process#GO:0050793;biological regulation#GO:0065007;regulation of cell projection organization#GO:0031344;regulation of synapse organization#GO:0050807;regulation of dendritic spine morphogenesis#GO:0061001;regulation of anatomical structure morphogenesis#GO:0022603;regulation of synapse structure or activity#GO:0050803;regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of biological quality#GO:0065008 membraneless organelle#GO:0043228;cell junction#GO:0030054;cytoskeleton#GO:0005856;neuron to neuron synapse#GO:0098984;postsynaptic specialization#GO:0099572;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;intracellular anatomical structure#GO:0005622;postsynaptic density#GO:0014069;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;asymmetric synapse#GO:0032279;postsynapse#GO:0098794;actin cytoskeleton#GO:0015629 HUMAN|HGNC=6270|UniProtKB=Q92806 Q92806 KCNJ9 PTHR11767:SF17 INWARD RECTIFIER POTASSIUM CHANNEL G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 3 voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;transporter activity#GO:0005215;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276;potassium channel activity#GO:0005267;monoatomic cation channel activity#GO:0005261;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857 potassium ion import across plasma membrane#GO:1990573;import into cell#GO:0098657;establishment of localization#GO:0051234;inorganic cation import across plasma membrane#GO:0098659;transport#GO:0006810;potassium ion transport#GO:0006813;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;import across plasma membrane#GO:0098739;metal ion transport#GO:0030001;inorganic ion import across plasma membrane#GO:0099587 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 ion channel#PC00133 Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>GIRK#P01083;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GPRK#P00741;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GIRK#P00724 HUMAN|HGNC=10676|UniProtKB=Q9HCN8 Q9HCN8 SDF2L1 PTHR46809:SF1 STROMAL CELL-DERIVED FACTOR 2-LIKE PROTEIN STROMAL CELL-DERIVED FACTOR 2-LIKE PROTEIN 1 HUMAN|HGNC=28875|UniProtKB=Q8WZ79 Q8WZ79 DNASE2B PTHR10858:SF2 DEOXYRIBONUCLEASE II DEOXYRIBONUCLEASE-2-BETA DNA endonuclease activity#GO:0004520;hydrolase activity#GO:0016787;nuclease activity#GO:0004518;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity, acting on ester bonds#GO:0016788;DNA nuclease activity#GO:0004536;catalytic activity, acting on DNA#GO:0140097;endonuclease activity#GO:0004519 execution phase of apoptosis#GO:0097194;apoptotic process#GO:0006915;cell death#GO:0008219;programmed cell death#GO:0012501;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;catabolic process#GO:0009056;DNA catabolic process#GO:0006308;cellular component disassembly#GO:0022411;nucleic acid catabolic process#GO:0141188;cellular process#GO:0009987;nucleobase-containing compound catabolic process#GO:0034655;apoptotic DNA fragmentation#GO:0006309;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840 endodeoxyribonuclease#PC00093 HUMAN|HGNC=23682|UniProtKB=Q8IY26 Q8IY26 PLPP6 PTHR14969:SF18 SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE POLYISOPRENOID DIPHOSPHATE_PHOSPHATE PHOSPHOHYDROLASE PLPP6 catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578 lipid metabolic process#GO:0006629;metabolic process#GO:0008152;dephosphorylation#GO:0016311;lipid modification#GO:0030258;phospholipid dephosphorylation#GO:0046839;phosphate-containing compound metabolic process#GO:0006796;cellular process#GO:0009987;primary metabolic process#GO:0044238 cellular anatomical structure#GO:0110165;membrane#GO:0016020 phosphatase#PC00181;hydrolase#PC00121 HUMAN|HGNC=11599|UniProtKB=Q9UL17 Q9UL17 TBX21 PTHR11267:SF125 T-BOX PROTEIN-RELATED T-BOX TRANSCRIPTION FACTOR TBX21 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 cell fate commitment#GO:0045165;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;immune system process#GO:0002376;mononuclear cell migration#GO:0071674;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;cell motility#GO:0048870;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;cell fate specification#GO:0001708;leukocyte migration#GO:0050900;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;cell migration#GO:0016477;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;lymphocyte migration#GO:0072676;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 immunoglobulin fold transcription factor#PC00251;Rel homology transcription factor#PC00252 HUMAN|HGNC=20681|UniProtKB=Q6ZS30 Q6ZS30 NBEAL1 PTHR13743:SF115 BEIGE/BEACH-RELATED NEUROBEACHIN-LIKE PROTEIN 1 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;membrane#GO:0016020;cytosol#GO:0005829 scaffold/adaptor protein#PC00226 HUMAN|HGNC=2398|UniProtKB=P43320 P43320 CRYBB2 PTHR11818:SF11 BETA/GAMMA CRYSTALLIN BETA-CRYSTALLIN B2 structural molecule activity#GO:0005198 sensory system development#GO:0048880;multicellular organismal process#GO:0032501;lens development in camera-type eye#GO:0002088;developmental process#GO:0032502;sensory organ development#GO:0007423;system process#GO:0003008;animal organ development#GO:0048513;multicellular organism development#GO:0007275;sensory perception of light stimulus#GO:0050953;visual system development#GO:0150063;visual perception#GO:0007601;nervous system process#GO:0050877;sensory perception#GO:0007600;animal gross anatomical part developmental process#GO:0160108;camera-type eye development#GO:0043010;eye development#GO:0001654;system development#GO:0048731;anatomical structure development#GO:0048856 structural protein#PC00211 HUMAN|HGNC=20145|UniProtKB=P51810 P51810 GPR143 PTHR15177:SF2 G-PROTEIN COUPLED RECEPTOR 143 G PROTEIN-COUPLED RECEPTOR 143 molecular transducer activity#GO:0060089;cation binding#GO:0043169;ion binding#GO:0043167;neuropeptide receptor activity#GO:0008188;binding#GO:0005488;anion binding#GO:0043168;small molecule binding#GO:0036094;carboxylic acid binding#GO:0031406;organic acid binding#GO:0043177;transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;signaling receptor activity#GO:0038023;amino acid binding#GO:0016597 organelle organization#GO:0006996;signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;cellular pigmentation#GO:0033059;melanosome organization#GO:0032438;cellular component organization or biogenesis#GO:0071840;vesicle organization#GO:0016050;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;G protein-coupled receptor signaling pathway#GO:0007186;pigmentation#GO:0043473;cell communication#GO:0007154 plasma membrane#GO:0005886;cytoplasm#GO:0005737;melanosome#GO:0042470;plasma membrane region#GO:0098590;cytoplasmic vesicle membrane#GO:0030659;cell periphery#GO:0071944;vesicle membrane#GO:0012506;membrane#GO:0016020;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;apical part of cell#GO:0045177;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;apical plasma membrane#GO:0016324;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=16249|UniProtKB=Q9H3Y0 Q9H3Y0 R3HDML PTHR10334:SF62 CYSTEINE-RICH SECRETORY PROTEIN-RELATED PEPTIDASE INHIBITOR R3HDML extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090 HUMAN|HGNC=24756|UniProtKB=Q6ZP01 Q6ZP01 RBM44 PTHR48026:SF8 HOMOLOGOUS TO DROSOPHILA SQD (SQUID) PROTEIN RNA-BINDING PROTEIN 44 binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723;mRNA 3'-UTR binding#GO:0003730 nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;spliceosomal complex#GO:0005681;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;catalytic step 2 spliceosome#GO:0071013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ribonucleoprotein complex#GO:1990904 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HUMAN|HGNC=32672|UniProtKB=Q9BRX9 Q9BRX9 WDR83 PTHR22842:SF3 WD40 REPEAT PROTEIN WD REPEAT DOMAIN-CONTAINING PROTEIN 83 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170 ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;catalytic step 2 spliceosome#GO:0071013;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;spliceosomal complex#GO:0005681;nucleus#GO:0005634;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=34416|UniProtKB=P0C263 P0C263 SBK2 PTHR48013:SF7 DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED SERINE_THREONINE-PROTEIN KINASE SBK2 catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;protein kinase activity#GO:0004672 intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;MAPK cascade#GO:0000165 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=23484|UniProtKB=Q5VWN6 Q5VWN6 TASOR2 PTHR16207:SF10 SET DOMAIN-CONTAINING PROTEIN PROTEIN TASOR 2 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=6912|UniProtKB=P43243 P43243 MATR3 PTHR15592:SF2 MATRIN 3/NUCLEAR PROTEIN 220-RELATED MATRIN-3 mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 RNA processing factor#PC00147 HUMAN|HGNC=1399|UniProtKB=P54289 P54289 CACNA2D1 PTHR10166:SF6 VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2_DELTA-1 gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;voltage-gated channel activity#GO:0022832;transporter activity#GO:0005215;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;voltage-gated calcium channel activity#GO:0005245;calcium channel activity#GO:0005262;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261 membrane#GO:0016020;voltage-gated calcium channel complex#GO:0005891;membrane protein complex#GO:0098796;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;calcium channel complex#GO:0034704;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;cation channel complex#GO:0034703;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;sarcolemma#GO:0042383 transporter#PC00227;voltage-gated ion channel#PC00241 Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>Ca2+ channel#P01081 HUMAN|HGNC=5298|UniProtKB=O95264 O95264 HTR3B PTHR18945:SF53 NEUROTRANSMITTER GATED ION CHANNEL 5-HYDROXYTRYPTAMINE RECEPTOR 3B transporter activity#GO:0005215;neurotransmitter receptor activity#GO:0030594;signaling receptor activity#GO:0038023;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;gated channel activity#GO:0022836;transmembrane signaling receptor activity#GO:0004888;monoatomic cation transmembrane transporter activity#GO:0008324;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261;ligand-gated monoatomic ion channel activity#GO:0015276;channel activity#GO:0015267;molecular transducer activity#GO:0060089 metal ion transport#GO:0030001;signaling#GO:0023052;anterograde trans-synaptic signaling#GO:0098916;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;cell communication#GO:0007154;localization#GO:0051179;monoatomic cation transport#GO:0006812;trans-synaptic signaling#GO:0099537;monoatomic ion transmembrane transport#GO:0034220;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;synaptic transmission, cholinergic#GO:0007271;cellular process#GO:0009987;synaptic signaling#GO:0099536;calcium ion transport#GO:0006816;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;transport#GO:0006810 plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane#GO:0016020;membrane protein complex#GO:0098796;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;signaling receptor complex#GO:0043235;cation channel complex#GO:0034703 ligand-gated ion channel#PC00141 5HT3 type receptor mediated signaling pathway#P04375>5HT3 Rec#P04422 HUMAN|HGNC=33867|UniProtKB=A6NFY7 A6NFY7 SDHAF1 PTHR47046:SF1 SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 1, MITOCHONDRIAL SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 1, MITOCHONDRIAL protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;mitochondrial respiratory chain complex II assembly#GO:0034553;mitochondrion organization#GO:0007005;mitochondrial respiratory chain complex assembly#GO:0033108;cellular component assembly#GO:0022607 mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HUMAN|HGNC=11530|UniProtKB=P09758 P09758 TACSTD2 PTHR14168:SF5 TUMOR-ASSOCIATED CALCIUM SIGNAL TRANSDUCER TUMOR-ASSOCIATED CALCIUM SIGNAL TRANSDUCER 2 regulation of cellular process#GO:0050794;regulation of cell adhesion#GO:0030155;negative regulation of cell adhesion#GO:0007162;biological regulation#GO:0065007;regulation of cell-substrate adhesion#GO:0010810;cell-cell adhesion#GO:0098609;negative regulation of biological process#GO:0048519;cellular process#GO:0009987;regulation of biological process#GO:0050789;negative regulation of cellular process#GO:0048523;cell adhesion#GO:0007155 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;bicellular tight junction#GO:0005923;plasma membrane region#GO:0098590;cell periphery#GO:0071944;basal plasma membrane#GO:0009925;membrane#GO:0016020;cell-cell junction#GO:0005911;basal part of cell#GO:0045178;basolateral plasma membrane#GO:0016323;anchoring junction#GO:0070161;tight junction#GO:0070160;cell junction#GO:0030054;extracellular region#GO:0005576;apical junction complex#GO:0043296 HUMAN|HGNC=33713|UniProtKB=A6NEN9 A6NEN9 CXorf65 PTHR33887:SF4 PB1 DOMAIN-CONTAINING PROTEIN CHROMOSOME X OPEN READING FRAME 65 HUMAN|HGNC=19398|UniProtKB=Q96JS3 Q96JS3 PGBD1 PTHR47055:SF1 DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 1 nucleic acid binding#GO:0003676;binding#GO:0005488;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677 HUMAN|HGNC=18713|UniProtKB=Q86VQ1 Q86VQ1 GLCCI1 PTHR14972:SF3 AGAP011572-PA GLUCOCORTICOID-INDUCED TRANSCRIPT 1 PROTEIN intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=16040|UniProtKB=Q96DT6 Q96DT6 ATG4C PTHR22624:SF38 CYSTEINE PROTEASE ATG4 CYSTEINE PROTEASE ATG4C catalytic activity, acting on a protein#GO:0140096;cysteine-type endopeptidase activity#GO:0004197;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;protein-phosphatidylethanolamide deconjugating activity#GO:0019786;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;hydrolase activity#GO:0016787 protein metabolic process#GO:0019538;vacuole organization#GO:0007033;process utilizing autophagic mechanism#GO:0061919;organelle assembly#GO:0070925;proteolysis#GO:0006508;catabolic process#GO:0009056;piecemeal microautophagy of the nucleus#GO:0034727;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;mitophagy#GO:0000423;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;autophagosome assembly#GO:0000045;metabolic process#GO:0008152;autophagy of mitochondrion#GO:0000422;cellular component assembly#GO:0022607;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;macroautophagy#GO:0016236;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;autophagy#GO:0006914;autophagosome organization#GO:1905037;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein processing#GO:0016485 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 cysteine protease#PC00081 HUMAN|HGNC=15740|UniProtKB=Q9UI42 Q9UI42 CPA4 PTHR11705:SF136 PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B CARBOXYPEPTIDASE A4 peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;metalloexopeptidase activity#GO:0008235;catalytic activity#GO:0003824;carboxypeptidase activity#GO:0004180;exopeptidase activity#GO:0008238;hydrolase activity#GO:0016787;metallocarboxypeptidase activity#GO:0004181;metallopeptidase activity#GO:0008237 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;proteolysis#GO:0006508;metabolic process#GO:0008152;primary metabolic process#GO:0044238;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 metalloprotease#PC00153 HUMAN|HGNC=10294|UniProtKB=Q16518 Q16518 RPE65 PTHR10543:SF57 BETA-CAROTENE DIOXYGENASE RETINOID ISOMEROHYDROLASE carboxylic ester hydrolase activity#GO:0052689;hydrolase activity#GO:0016787;dioxygenase activity#GO:0051213;oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen#GO:0016702;cis-trans isomerase activity#GO:0016859;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;oxidoreductase activity#GO:0016491;isomerase activity#GO:0016853 catabolic process#GO:0009056;carotenoid biosynthetic process#GO:0016117;primary metabolic process#GO:0044238;carotenoid metabolic process#GO:0016116;isoprenoid metabolic process#GO:0006720;olefinic compound metabolic process#GO:0120254;isoprenoid biosynthetic process#GO:0008299;terpenoid metabolic process#GO:0006721;terpenoid biosynthetic process#GO:0016114;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058;pigment metabolic process#GO:0042440;xanthophyll biosynthetic process#GO:0016123;tetraterpenoid biosynthetic process#GO:0016109;cellular process#GO:0009987;aldehyde metabolic process#GO:0006081;lipid catabolic process#GO:0016042;retinoid metabolic process#GO:0001523;diterpenoid metabolic process#GO:0016101;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;pigment biosynthetic process#GO:0046148 oxygenase#PC00177;oxidoreductase#PC00176 HUMAN|HGNC=18746|UniProtKB=P55000 P55000 SLURP1 PTHR10036:SF17 CD59 GLYCOPROTEIN SECRETED LY-6_UPAR-RELATED PROTEIN 1 signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;neurotransmitter receptor regulator activity#GO:0099602;acetylcholine receptor regulator activity#GO:0030548;signaling receptor regulator activity#GO:0030545 HUMAN|HGNC=6720|UniProtKB=P02788 P02788 LTF PTHR11485:SF55 TRANSFERRIN LACTOTRANSFERRIN response to bacterium#GO:0009617;immune system process#GO:0002376;iron ion transport#GO:0006826;defense response to bacterium#GO:0042742;transition metal ion transport#GO:0000041;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;response to stimulus#GO:0050896;response to external biotic stimulus#GO:0043207;metal ion transport#GO:0030001;biological process involved in interspecies interaction between organisms#GO:0044419;antimicrobial humoral response#GO:0019730;humoral immune response#GO:0006959;transport#GO:0006810;establishment of localization#GO:0051234;antibacterial humoral response#GO:0019731;response to external stimulus#GO:0009605;defense response#GO:0006952;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;defense response to symbiont#GO:0140546;immune response#GO:0006955;defense response to other organism#GO:0098542;response to other organism#GO:0051707 recycling endosome#GO:0055037;membrane#GO:0016020;cell periphery#GO:0071944;endomembrane system#GO:0012505;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;extracellular region#GO:0005576;endosome#GO:0005768;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 transfer/carrier protein#PC00219 HUMAN|HGNC=28424|UniProtKB=Q9BQ61 Q9BQ61 TRIR PTHR34753:SF1 TELOMERASE RNA COMPONENT INTERACTING RNASE TELOMERASE RNA COMPONENT-INTERACTING RNASE hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;3'-5' exonuclease activity#GO:0008408;exonuclease activity#GO:0004527;5'-3' exonuclease activity#GO:0008409;nuclease activity#GO:0004518;hydrolase activity#GO:0016787 DNA metabolism protein#PC00009 HUMAN|HGNC=41907|UniProtKB=Q6NZ63 Q6NZ63 STEAP1B PTHR14239:SF3 DUDULIN-RELATED STEAP FAMILY MEMBER 1B-RELATED oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on metal ions#GO:0016722;catalytic activity#GO:0003824;ferric-chelate reductase activity#GO:0000293 monoatomic ion transport#GO:0006811;metal ion transport#GO:0030001;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;localization#GO:0051179;transition metal ion transport#GO:0000041;transport#GO:0006810 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular vesicle#GO:0097708;membrane#GO:0016020;vesicle#GO:0031982;cell periphery#GO:0071944;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768 reductase#PC00198 HUMAN|HGNC=24173|UniProtKB=Q9H3M9 Q9H3M9 ATXN3L PTHR14159:SF0 ATAXIN-3-RELATED ATAXIN-3-RELATED cysteine-type peptidase activity#GO:0008234;cysteine-type deubiquitinase activity#GO:0004843;catalytic activity#GO:0003824;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity, acting on a protein#GO:0140096;deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787 positive regulation of macromolecule metabolic process#GO:0010604;regulation of proteasomal protein catabolic process#GO:0061136;negative regulation of signal transduction#GO:0009968;proteasomal protein catabolic process#GO:0010498;regulation of protein metabolic process#GO:0051246;cellular process#GO:0009987;regulation of TOR signaling#GO:0032006;positive regulation of biological process#GO:0048518;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;negative regulation of TORC1 signaling#GO:1904262;negative regulation of biological process#GO:0048519;positive regulation of proteasomal protein catabolic process#GO:1901800;regulation of biological process#GO:0050789;negative regulation of intracellular signal transduction#GO:1902532;positive regulation of metabolic process#GO:0009893;negative regulation of cell communication#GO:0010648;regulation of cellular response to stress#GO:0080135;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;positive regulation of protein metabolic process#GO:0051247;modification-dependent macromolecule catabolic process#GO:0043632;regulation of signaling#GO:0023051;protein catabolic process#GO:0030163;negative regulation of response to stimulus#GO:0048585;positive regulation of response to stimulus#GO:0048584;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of catabolic process#GO:0009896;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;regulation of catabolic process#GO:0009894;regulation of TORC1 signaling#GO:1903432;regulation of response to stress#GO:0080134;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of cellular process#GO:0050794;protein quality control for misfolded or incompletely synthesized proteins#GO:0006515;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;negative regulation of TOR signaling#GO:0032007;regulation of cell communication#GO:0010646;regulation of ERAD pathway#GO:1904292;primary metabolic process#GO:0044238;regulation of response to endoplasmic reticulum stress#GO:1905897;modification-dependent protein catabolic process#GO:0019941;protein metabolic process#GO:0019538;regulation of protein catabolic process#GO:0042176;positive regulation of protein catabolic process#GO:0045732 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=19124|UniProtKB=Q6UN15 Q6UN15 FIP1L1 PTHR13484:SF9 FIP1-LIKE 1 PROTEIN PRE-MRNA 3'-END-PROCESSING FACTOR FIP1 mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;RNA 3'-end processing#GO:0031123;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;mRNA 3'-end processing#GO:0031124;nucleobase-containing compound biosynthetic process#GO:0034654 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;mRNA cleavage and polyadenylation specificity factor complex#GO:0005847;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;mRNA cleavage factor complex#GO:0005849;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 HUMAN|HGNC=2042|UniProtKB=P56880 P56880 CLDN20 PTHR12002:SF17 CLAUDIN CLAUDIN-20 cell-cell junction assembly#GO:0007043;cell-cell junction organization#GO:0045216;cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;cell junction assembly#GO:0034329;cellular process#GO:0009987;cell junction organization#GO:0034330;cellular component assembly#GO:0022607 anchoring junction#GO:0070161;cell junction#GO:0030054;tight junction#GO:0070160;apical junction complex#GO:0043296;plasma membrane#GO:0005886;bicellular tight junction#GO:0005923;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;cell-cell junction#GO:0005911 cell junction protein#PC00070;tight junction#PC00214 HUMAN|HGNC=22989|UniProtKB=Q8NFW1 Q8NFW1 COL22A1 PTHR24023:SF845 COLLAGEN ALPHA COLLAGEN ALPHA-1(XXII) CHAIN extracellular matrix structural constituent#GO:0005201;structural molecule activity#GO:0005198 external encapsulating structure organization#GO:0045229;cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;cellular process#GO:0009987;extracellular structure organization#GO:0043062;cellular component organization#GO:0016043 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;basement membrane#GO:0005604;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 extracellular matrix structural protein#PC00103;extracellular matrix protein#PC00102 HUMAN|HGNC=13480|UniProtKB=Q8IYT8 Q8IYT8 ULK2 PTHR24348:SF18 SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED SERINE_THREONINE-PROTEIN KINASE ULK2 protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824 regulation of cell size#GO:0008361;developmental growth involved in morphogenesis#GO:0060560;generation of neurons#GO:0048699;cell projection organization#GO:0030030;cell differentiation#GO:0030154;regulation of multicellular organismal development#GO:2000026;regulation of cellular component size#GO:0032535;cellular component organization#GO:0016043;regulation of axonogenesis#GO:0050770;cell projection morphogenesis#GO:0048858;cell growth#GO:0016049;plasma membrane bounded cell projection morphogenesis#GO:0120039;metabolic process#GO:0008152;regulation of multicellular organismal process#GO:0051239;cellular component assembly#GO:0022607;regulation of cell growth#GO:0001558;autophagy#GO:0006914;response to stress#GO:0006950;vacuole organization#GO:0007033;system development#GO:0048731;regulation of nervous system development#GO:0051960;organelle assembly#GO:0070925;regulation of developmental process#GO:0050793;catabolic process#GO:0009056;regulation of growth#GO:0040008;negative regulation of cellular component organization#GO:0051129;response to starvation#GO:0042594;cellular developmental process#GO:0048869;developmental process#GO:0032502;autophagy of mitochondrion#GO:0000422;macroautophagy#GO:0016236;negative regulation of cell growth#GO:0030308;plasma membrane bounded cell projection organization#GO:0120036;reticulophagy#GO:0061709;axon development#GO:0061564;response to nutrient levels#GO:0031667;neuron projection extension#GO:1990138;process utilizing autophagic mechanism#GO:0061919;regulation of biological quality#GO:0065008;neuron development#GO:0048666;axonogenesis#GO:0007409;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;cell morphogenesis#GO:0000902;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;negative regulation of biological process#GO:0048519;regulation of autophagy#GO:0010506;autophagosome assembly#GO:0000045;regulation of anatomical structure morphogenesis#GO:0022603;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;growth#GO:0040007;neuron differentiation#GO:0030182;regulation of anatomical structure size#GO:0090066;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;axon extension#GO:0048675;cellular process#GO:0009987;autophagosome organization#GO:1905037;regulation of neuron projection development#GO:0010975;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;neuron projection development#GO:0031175;anatomical structure development#GO:0048856;developmental cell growth#GO:0048588;piecemeal microautophagy of the nucleus#GO:0034727;regulation of cellular process#GO:0050794;regulation of neurogenesis#GO:0050767;negative regulation of multicellular organismal process#GO:0051241;regulation of catabolic process#GO:0009894;neurogenesis#GO:0022008;developmental growth#GO:0048589;mitophagy#GO:0000423;regulation of plasma membrane bounded cell projection organization#GO:0120035;neuron projection morphogenesis#GO:0048812;regulation of cell differentiation#GO:0045595;negative regulation of cellular process#GO:0048523;regulation of cell projection organization#GO:0031344;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regulation of cell development#GO:0060284;regulation of metabolic process#GO:0019222 membrane#GO:0016020;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;vacuole#GO:0005773;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;phagophore assembly site#GO:0000407;autophagosome#GO:0005776;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=8934|UniProtKB=Q9Y5J5 Q9Y5J5 PHLDA3 PTHR15478:SF5 PLECKSTRIN HOMOLOGY-LIKE DOMAIN, PQ-RICH PROTEIN PLECKSTRIN HOMOLOGY-LIKE DOMAIN FAMILY A MEMBER 3 cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;response to stress#GO:0006950;intrinsic apoptotic signaling pathway in response to DNA damage#GO:0008630;negative regulation of signal transduction#GO:0009968;regulation of apoptotic process#GO:0042981;positive regulation of apoptotic process#GO:0043065;apoptotic process#GO:0006915;regulation of biological process#GO:0050789;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;signaling#GO:0023052;positive regulation of programmed cell death#GO:0043068;intrinsic apoptotic signaling pathway by p53 class mediator#GO:0072332;response to stimulus#GO:0050896;regulation of signaling#GO:0023051;cellular response to stress#GO:0033554;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;signal transduction by p53 class mediator#GO:0072331;negative regulation of cell communication#GO:0010648;intrinsic apoptotic signaling pathway#GO:0097193;negative regulation of intracellular signal transduction#GO:1902532;positive regulation of cellular process#GO:0048522;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of response to stimulus#GO:0048585;regulation of response to stimulus#GO:0048583;DNA damage response#GO:0006974;negative regulation of cellular process#GO:0048523;apoptotic signaling pathway#GO:0097190;cellular response to stimulus#GO:0051716;cell death#GO:0008219;intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator#GO:0042771;programmed cell death#GO:0012501;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;intracellular signal transduction#GO:0035556;regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051896;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=3019|UniProtKB=Q14919 Q14919 DRAP1 PTHR10252:SF163 HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED DR1-ASSOCIATED COREPRESSOR DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;core promoter sequence-specific DNA binding#GO:0001046;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 DNA-templated transcription#GO:0006351;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA biosynthetic process#GO:0032774;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;nucleic acid biosynthetic process#GO:0141187;transcription by RNA polymerase II#GO:0006366;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;transcription repressor complex#GO:0017053;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 DNA-binding transcription factor#PC00218 HUMAN|HGNC=6854|UniProtKB=Q9Y2U5 Q9Y2U5 MAP3K2 PTHR24361:SF342 MITOGEN-ACTIVATED KINASE KINASE KINASE MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 2 transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 biological regulation#GO:0065007;signaling#GO:0023052;intracellular signaling cassette#GO:0141124;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;MAPK cascade#GO:0000165 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Gonadotropin-releasing hormone receptor pathway#P06664>MAP3Ks#P06834;PDGF signaling pathway#P00047>ERK#P01143;B cell activation#P00010>MEKK#P00369;FGF signaling pathway#P00021>MEKK1-5#P00634;EGF receptor signaling pathway#P00018>MEKK1-5#P00553;Integrin signalling pathway#P00034>ERK#P00907 HUMAN|HGNC=12723|UniProtKB=Q9NZR4 Q9NZR4 VSX1 PTHR24323:SF3 CEH-10 HOMEODOMAIN-CONTAINING HOMOLOG VISUAL SYSTEM HOMEOBOX 1 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690 regulation of biological process#GO:0050789;cell development#GO:0048468;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;neuron development#GO:0048666;regulation of RNA metabolic process#GO:0051252;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;nervous system development#GO:0007399;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;developmental process#GO:0032502;neuron differentiation#GO:0030182;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 HUMAN|HGNC=26252|UniProtKB=Q5VTH9 Q5VTH9 DNAI4 PTHR12442:SF12 DYNEIN INTERMEDIATE CHAIN DYNEIN AXONEMAL INTERMEDIATE CHAIN 4 protein binding#GO:0005515;binding#GO:0005488 cellular process#GO:0009987;cilium movement#GO:0003341;microtubule-based process#GO:0007017;microtubule-based movement#GO:0007018 membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;ciliary plasm#GO:0097014;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;axoneme#GO:0005930;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cilium#GO:0005929;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;axonemal dynein complex#GO:0005858;dynein complex#GO:0030286 microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=8207|UniProtKB=O60431 O60431 OR1I1 PTHR48001:SF53 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 1I1 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=29334|UniProtKB=Q9HCC9 Q9HCC9 ZFYVE28 PTHR46465:SF3 LATERAL SIGNALING TARGET PROTEIN 2 HOMOLOG LATERAL SIGNALING TARGET PROTEIN 2 HOMOLOG regulation of biological process#GO:0050789;regulation of ERBB signaling pathway#GO:1901184;negative regulation of biological process#GO:0048519;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cell communication#GO:0010646;negative regulation of signal transduction#GO:0009968;regulation of epidermal growth factor receptor signaling pathway#GO:0042058;regulation of cellular process#GO:0050794;negative regulation of response to stimulus#GO:0048585;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;negative regulation of cellular process#GO:0048523;negative regulation of cell communication#GO:0010648 early endosome membrane#GO:0031901;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;membrane#GO:0016020;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;endosome#GO:0005768;endosome membrane#GO:0010008;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=23916|UniProtKB=A6NEQ0 A6NEQ0 RBMY1E PTHR48034:SF17 TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED RNA-BINDING MOTIF PROTEIN, Y CHROMOSOME, FAMILY 1 MEMBER A1-RELATED RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676 mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;spliceosomal complex#GO:0005681;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904 RNA metabolism protein#PC00031 HUMAN|HGNC=5569|UniProtKB=A0A0B4J2B8 A0A0B4J2B8 IGHV1OR15-9 PTHR23266:SF100 IMMUNOGLOBULIN HEAVY CHAIN IG-LIKE DOMAIN-CONTAINING PROTEIN antigen binding#GO:0003823;binding#GO:0005488 immune response#GO:0006955;response to stimulus#GO:0050896;adaptive immune response#GO:0002250;immune system process#GO:0002376;immune effector process#GO:0002252;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=29427|UniProtKB=Q8TF17 Q8TF17 SH3TC2 PTHR22647:SF2 SH3 DOMAIN AND TETRATRICOPEPTIDE REPEATS CONTAINING PROTEIN SH3 DOMAIN AND TETRATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 2 regulation of biological process#GO:0050789;regulation of ERBB signaling pathway#GO:1901184;regulation of protein transport#GO:0051223;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cell communication#GO:0010646;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;regulation of localization#GO:0032879;regulation of establishment of protein localization#GO:0070201;regulation of transport#GO:0051049;regulation of protein localization#GO:0032880 scaffold/adaptor protein#PC00226 HUMAN|HGNC=51507|UniProtKB=P0DTA3 P0DTA3 SPDYE11 PTHR31156:SF15 WBSCR19-LIKE PROTEIN SPEEDY PROTEIN E10-RELATED HUMAN|HGNC=30055|UniProtKB=Q12893 Q12893 TMEM115 PTHR13377:SF3 PLACENTAL PROTEIN 6 TRANSMEMBRANE PROTEIN 115 cellular process#GO:0009987;transport#GO:0006810;Golgi vesicle transport#GO:0048193;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;localization#GO:0051179 organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;Golgi cisterna#GO:0031985;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;Golgi stack#GO:0005795;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791 membrane traffic protein#PC00150;vesicle coat protein#PC00235 HUMAN|HGNC=8697|UniProtKB=Q9Y5H3 Q9Y5H3 PCDHGA10 PTHR24028:SF110 CADHERIN-87A PROTOCADHERIN GAMMA-A10 cell adhesion#GO:0007155;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HUMAN|HGNC=218|UniProtKB=O95450 O95450 ADAMTS2 PTHR13723:SF141 ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 2 metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 cellular component organization#GO:0016043;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;protein metabolic process#GO:0019538;external encapsulating structure organization#GO:0045229;metabolic process#GO:0008152;proteolysis#GO:0006508;extracellular structure organization#GO:0043062 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 metalloprotease#PC00153 HUMAN|HGNC=26512|UniProtKB=Q5VW32 Q5VW32 BROX PTHR23032:SF13 BRO1 DOMAIN-CONTAINING PROTEIN BROX BRO1 DOMAIN-CONTAINING PROTEIN BROX HUMAN|HGNC=24762|UniProtKB=P61129 P61129 ZC3H6 PTHR13119:SF22 ZINC FINGER CCCH DOMAIN-CONTAINING PROTEI ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 6 DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;transcription regulator activity#GO:0140110;DNA-binding transcription repressor activity#GO:0001217;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription elongation#GO:0032784;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233 zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=4104|UniProtKB=O76087 O76087 GAGE7 PTHR14047:SF30 P ANTIGEN FAMILY MEMBER 5-RELATED G ANTIGEN 1-RELATED HUMAN|HGNC=11276|UniProtKB=O15020 O15020 SPTBN2 PTHR11915:SF325 SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN SPECTRIN BETA CHAIN, NON-ERYTHROCYTIC 2 cytoskeletal protein binding#GO:0008092;structural molecule activity#GO:0005198;actin binding#GO:0003779;actin filament binding#GO:0051015;binding#GO:0005488;protein-containing complex binding#GO:0044877;structural constituent of synapse#GO:0098918;protein binding#GO:0005515 cellular process#GO:0009987;actin filament-based process#GO:0030029;organelle organization#GO:0006996;cellular component organization#GO:0016043;cytoskeleton organization#GO:0007010;cellular component organization or biogenesis#GO:0071840;actin cytoskeleton organization#GO:0030036 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cell cortex#GO:0005938;actin cytoskeleton#GO:0015629;cortical cytoskeleton#GO:0030863;cell projection#GO:0042995;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoskeleton#GO:0005856;cell junction#GO:0030054;membraneless organelle#GO:0043228;cell periphery#GO:0071944;membrane#GO:0016020;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;cytoplasm#GO:0005737;cortical actin cytoskeleton#GO:0030864 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=4194|UniProtKB=P30047 P30047 GCHFR PTHR16852:SF2 GTP CYCLOHYDROLASE 1 FEEDBACK REGULATORY PROTEIN GTP CYCLOHYDROLASE 1 FEEDBACK REGULATORY PROTEIN enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;molecular function regulator activity#GO:0098772;enzyme inhibitor activity#GO:0004857 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 protein-binding activity modulator#PC00095 HUMAN|HGNC=9193|UniProtKB=P61218 P61218 POLR2F PTHR47227:SF5 DNA-DIRECTED RNA POLYMERASE SUBUNIT K DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2 catalytic activity#GO:0003824;transferase activity#GO:0016740;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on RNA#GO:0140098 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;transcription by RNA polymerase III#GO:0006383;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;transcription by RNA polymerase I#GO:0006360;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;transcription by RNA polymerase II#GO:0006366;macromolecule metabolic process#GO:0043170 transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;RNA polymerase III complex#GO:0005666;RNA polymerase I complex#GO:0005736;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;membrane-bounded organelle#GO:0043227;RNA polymerase II, holoenzyme#GO:0016591;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;RNA polymerase II, core complex#GO:0005665 DNA-directed RNA polymerase#PC00019 General transcription regulation#P00023>RNA Polymerase II#P00660;Transcription regulation by bZIP transcription factor#P00055>RNA Polymerase II#P01388 HUMAN|HGNC=473|UniProtKB=P48728 P48728 AMT PTHR43757:SF2 AMINOMETHYLTRANSFERASE AMINOMETHYLTRANSFERASE, MITOCHONDRIAL transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity#GO:0003824;transferase activity#GO:0016740 cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;amino acid metabolic process#GO:0006520;small molecule catabolic process#GO:0044282;proteinogenic amino acid metabolic process#GO:0170039;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 methyltransferase#PC00155;transferase#PC00220 HUMAN|HGNC=19246|UniProtKB=Q9NYB0 Q9NYB0 TERF2IP PTHR16466:SF6 TELOMERE REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1 TELOMERIC REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1 protein complex scaffold activity#GO:0140378;structural molecule activity#GO:0005198 metabolic process#GO:0008152;DNA metabolic process#GO:0006259;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;telomere maintenance#GO:0000723;chromosome organization#GO:0051276;telomere capping#GO:0016233;organelle organization#GO:0006996;response to stress#GO:0006950;cellular process#GO:0009987;telomere maintenance via telomere lengthening#GO:0010833;nucleobase-containing compound metabolic process#GO:0006139;cellular response to stress#GO:0033554;telomere organization#GO:0032200;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896 protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;chromosome, telomeric region#GO:0000781;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;protein-DNA complex#GO:0032993;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;nuclear telomere cap complex#GO:0000783;membrane-bounded organelle#GO:0043227;chromosome, telomeric repeat region#GO:0140445;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=18961|UniProtKB=Q8WTU0 Q8WTU0 DDI1 PTHR12917:SF15 ASPARTYL PROTEASE DDI-RELATED PROTEIN DDI1 HOMOLOG 1 hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity#GO:0003824;aspartic-type endopeptidase activity#GO:0004190 regulation of biological quality#GO:0065008;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;proteolysis#GO:0006508;metabolic process#GO:0008152;proteasomal protein catabolic process#GO:0010498;biological regulation#GO:0065007;catabolic process#GO:0009056;cellular process#GO:0009987;regulation of protein stability#GO:0031647;primary metabolic process#GO:0044238 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 aspartic protease#PC00053;protein modifying enzyme#PC00260 HUMAN|HGNC=23732|UniProtKB=Q66LE6 Q66LE6 PPP2R2D PTHR11871:SF6 PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B DELTA ISOFORM phosphatase regulator activity#GO:0019208;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;protein phosphatase regulator activity#GO:0019888 cytosol#GO:0005829;catalytic complex#GO:1902494;protein serine/threonine phosphatase complex#GO:0008287;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195;protein modifying enzyme#PC00260 FGF signaling pathway#P00021>PP2A#P00629 HUMAN|HGNC=27380|UniProtKB=Q5U4P2 Q5U4P2 ASPHD1 PTHR46332:SF1 ASPARTATE BETA-HYDROXYLASE DOMAIN-CONTAINING PROTEIN 2 ASPARTATE BETA-HYDROXYLASE DOMAIN-CONTAINING PROTEIN 1 oxidoreductase#PC00176;hydroxylase#PC00122 HUMAN|HGNC=19967|UniProtKB=Q9P219 Q9P219 CCDC88C PTHR18947:SF31 HOOK PROTEINS PROTEIN DAPLE protein binding#GO:0005515;binding#GO:0005488;microtubule binding#GO:0008017;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092 cytoplasmic microtubule organization#GO:0031122;cellular component organization#GO:0016043;localization#GO:0051179;microtubule cytoskeleton organization#GO:0000226;cellular localization#GO:0051641;supramolecular fiber organization#GO:0097435;cytoskeleton-dependent intracellular transport#GO:0030705;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;microtubule-based process#GO:0007017;intracellular transport#GO:0046907;transport#GO:0006810 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;centrosome#GO:0005813;intracellular organelle#GO:0043229 membrane traffic protein#PC00150 HUMAN|HGNC=28492|UniProtKB=Q5HYJ3 Q5HYJ3 FAM76B PTHR46176:SF3 LD21662P PROTEIN FAM76B supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;nuclear body#GO:0016604;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membraneless organelle#GO:0043228;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear speck#GO:0016607;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 HUMAN|HGNC=14042|UniProtKB=Q9Y3B7 Q9Y3B7 MRPL11 PTHR11661:SF19 60S RIBOSOMAL PROTEIN L12 LARGE RIBOSOMAL SUBUNIT PROTEIN UL11M rRNA binding#GO:0019843;nucleic acid binding#GO:0003676;binding#GO:0005488;structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198;RNA binding#GO:0003723 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;translation#GO:0006412;metabolic process#GO:0008152;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238 mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;mitochondrial ribosome#GO:0005761;organellar ribosome#GO:0000313;membrane-bounded organelle#GO:0043227;ribosome#GO:0005840;mitochondrion#GO:0005739;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrial large ribosomal subunit#GO:0005762;membraneless organelle#GO:0043228;membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991 ribosomal protein#PC00202 HUMAN|HGNC=28726|UniProtKB=Q5U649 Q5U649 C12orf60 PTHR36289:SF1 CHROMOSOME 12 OPEN READING FRAME 60 CHROMOSOME 12 OPEN READING FRAME 60 HUMAN|HGNC=21423|UniProtKB=Q9NXV2 Q9NXV2 KCTD5 PTHR14958:SF12 POTASSIUM CHANNEL TETRAMERISATION DOMAIN CONTAINING PROTEIN BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD5 protein binding#GO:0005515;binding#GO:0005488 catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163 cytoplasm#GO:0005737;cullin-RING ubiquitin ligase complex#GO:0031461;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;ubiquitin ligase complex#GO:0000151;Cul3-RING ubiquitin ligase complex#GO:0031463 scaffold/adaptor protein#PC00226 HUMAN|HGNC=28079|UniProtKB=Q86UK7 Q86UK7 ZNF598 PTHR22938:SF0 ZINC FINGER PROTEIN 598 E3 UBIQUITIN-PROTEIN LIGASE ZNF598 protein-containing complex binding#GO:0044877;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;ribosome binding#GO:0043022;ribonucleoprotein complex binding#GO:0043021;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;binding#GO:0005488;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740 organelle organization#GO:0006996;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;post-translational protein modification#GO:0043687;biosynthetic process#GO:0009058;protein ubiquitination#GO:0016567;translational elongation#GO:0006414;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein modification process#GO:0036211;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;rescue of stalled cytosolic ribosome#GO:0072344;protein modification by small protein conjugation#GO:0032446;protein biosynthetic process#GO:0160307;cytoplasmic translation#GO:0002181;protein modification by small protein conjugation or removal#GO:0070647;translation#GO:0006412;cellular component disassembly#GO:0022411;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;organelle disassembly#GO:1903008 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=17823|UniProtKB=Q9BUW7 Q9BUW7 BBLN PTHR34344:SF1 UPF0184 PROTEIN C9ORF16 BUBLIN COILED-COIL PROTEIN cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular component organization#GO:0016043;cytoskeleton organization#GO:0007010;intermediate filament cytoskeleton organization#GO:0045104;cellular component assembly#GO:0022607;intermediate filament organization#GO:0045109;intermediate filament-based process#GO:0045103;intermediate filament bundle assembly#GO:0045110;supramolecular fiber organization#GO:0097435;cellular component organization or biogenesis#GO:0071840 supramolecular complex#GO:0099080;organelle#GO:0043226;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232;cell junction#GO:0030054;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;supramolecular fiber#GO:0099512;intermediate filament#GO:0005882;anchoring junction#GO:0070161;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 HUMAN|HGNC=26349|UniProtKB=Q96LK8 Q96LK8 SPATA32 PTHR37338:SF1 SPERMATOGENESIS-ASSOCIATED PROTEIN 32 SPERMATOGENESIS-ASSOCIATED PROTEIN 32 protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;binding#GO:0005488 male gamete generation#GO:0048232;gamete generation#GO:0007276;reproductive process#GO:0022414;developmental process involved in reproduction#GO:0003006;multicellular organismal reproductive process#GO:0048609;sexual reproduction#GO:0019953;spermatogenesis#GO:0007283;developmental process#GO:0032502 cellular anatomical structure#GO:0110165;perinuclear region of cytoplasm#GO:0048471;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=18638|UniProtKB=Q5T7P8 Q5T7P8 SYT6 PTHR10024:SF45 SYNAPTOTAGMIN SYNAPTOTAGMIN-6 protein binding#GO:0005515;lipid binding#GO:0008289;molecular function regulator activity#GO:0098772;molecular sensor activity#GO:0140299;SNARE binding#GO:0000149;phospholipid binding#GO:0005543;binding#GO:0005488 trans-synaptic signaling#GO:0099537;regulation of secretion#GO:0051046;localization#GO:0051179;cell communication#GO:0007154;regulation of secretion by cell#GO:1903530;regulation of exocytosis#GO:0017157;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;signaling#GO:0023052;transport#GO:0006810;establishment of localization#GO:0051234;regulation of transport#GO:0051049;regulation of localization#GO:0032879;synaptic signaling#GO:0099536;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;biological regulation#GO:0065007;cell-cell signaling#GO:0007267 exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;secretory vesicle#GO:0099503;membrane#GO:0016020;cell periphery#GO:0071944;endomembrane system#GO:0012505;transport vesicle#GO:0030133;cytoplasm#GO:0005737;plasma membrane#GO:0005886 membrane trafficking regulatory protein#PC00151 Synaptic vesicle trafficking#P05734>Synaptotagmin#P05769 HUMAN|HGNC=5422|UniProtKB=P01571 P01571 IFNA17 PTHR11691:SF66 TYPE I INTERFERON INTERFERON ALPHA-10-RELATED signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;cytokine activity#GO:0005125;cytokine receptor binding#GO:0005126;signaling receptor binding#GO:0005102;binding#GO:0005488;molecular function activator activity#GO:0140677;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;T cell activation#GO:0042110;biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052;response to stimulus#GO:0050896;B cell activation involved in immune response#GO:0002312;type I interferon-mediated signaling pathway#GO:0060337;immune system process#GO:0002376;cell activation involved in immune response#GO:0002263;response to peptide#GO:1901652;cellular process#GO:0009987;signal transduction#GO:0007165;defense response to symbiont#GO:0140546;lymphocyte activation involved in immune response#GO:0002285;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;T cell activation involved in immune response#GO:0002286;defense response to other organism#GO:0098542;response to cytokine#GO:0034097;lymphocyte activation#GO:0046649;response to chemical#GO:0042221;leukocyte activation involved in immune response#GO:0002366;natural killer cell activation#GO:0030101;immune effector process#GO:0002252;cell surface receptor signaling pathway#GO:0007166;humoral immune response#GO:0006959;B cell activation#GO:0042113;cellular response to stimulus#GO:0051716;leukocyte activation#GO:0045321;response to external biotic stimulus#GO:0043207;regulation of cellular process#GO:0050794;cell activation#GO:0001775;cytokine-mediated signaling pathway#GO:0019221;response to nitrogen compound#GO:1901698;cell communication#GO:0007154;immune response#GO:0006955;response to other organism#GO:0051707;adaptive immune response#GO:0002250;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;defense response#GO:0006952;response to external stimulus#GO:0009605;innate immune response#GO:0045087 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 cytokine#PC00083;interferon superfamily#PC00127 HUMAN|HGNC=53442|UniProtKB=A0A1B0GVS7 A0A1B0GVS7 MDFIC2 PTHR15304:SF2 MYOD FAMILY INHIBITOR MYOD FAMILY INHIBITOR DOMAIN-CONTAINING PROTEIN 2 negative regulation of cellular process#GO:0048523;regulation of MAPK cascade#GO:0043408;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of response to stimulus#GO:0048583;regulation of JNK cascade#GO:0046328;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;regulation of Wnt signaling pathway#GO:0030111;regulation of cell communication#GO:0010646 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=20434|UniProtKB=Q86YW5 Q86YW5 TREML1 PTHR11860:SF37 POLYMERIC-IMMUNOGLOBULIN RECEPTOR TREM-LIKE TRANSCRIPT 1 PROTEIN molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 signaling#GO:0023052;regulation of cellular process#GO:0050794;regulation of body fluid levels#GO:0050878;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;hemostasis#GO:0007599;regulation of biological quality#GO:0065008;wound healing#GO:0042060;cell communication#GO:0007154;cell activation#GO:0001775;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;cellular process#GO:0009987;signal transduction#GO:0007165;coagulation#GO:0050817;response to wounding#GO:0009611;response to stress#GO:0006950;blood coagulation#GO:0007596;platelet activation#GO:0030168 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=2348|UniProtKB=Q92793 Q92793 CREBBP PTHR13808:SF34 CBP/P300-RELATED CREB-BINDING PROTEIN protein N-acetyltransferase activity#GO:0034212;transcription coactivator activity#GO:0003713;transferase activity#GO:0016740;protein N-acyltransferase activity#GO:0140186;histone modifying activity#GO:0140993;acetyltransferase activity#GO:0016407;binding#GO:0005488;transcription regulator activity#GO:0140110;catalytic activity, acting on a protein#GO:0140096;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity#GO:0003824;transcription coregulator activity#GO:0003712;chromatin DNA binding#GO:0031490;DNA binding#GO:0003677;histone acetyltransferase activity#GO:0004402;nucleic acid binding#GO:0003676;protein-lysine-acetyltransferase activity#GO:0061733;acyltransferase activity#GO:0016746;N-acetyltransferase activity#GO:0008080;chromatin binding#GO:0003682 regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893 protein acetyltransferase complex#GO:0031248;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;acetyltransferase complex#GO:1902493;chromosome#GO:0005694;cellular anatomical structure#GO:0110165;organelle#GO:0043226;transferase complex#GO:1990234;membraneless organelle#GO:0043228;intracellular protein-containing complex#GO:0140535;transcription regulator complex#GO:0005667;histone acetyltransferase complex#GO:0000123;chromatin#GO:0000785;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232 histone modifying enzyme#PC00261 Wnt signaling pathway#P00057>CBP#P01448;Huntington disease#P00029>CBP#P00777;p53 pathway#P00059>CBP#P04623;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>CPB#P00702;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>CREB#P00713;TGF-beta signaling pathway#P00052>Co-activators corepressors#P01282;Transcription regulation by bZIP transcription factor#P00055>CBP/P300#P01387;Gonadotropin-releasing hormone receptor pathway#P06664>CBP#P06755;Hypoxia response via HIF activation#P00030>P300#P00814;Hedgehog signaling pathway#P00025>CBP#P00691 HUMAN|HGNC=29836|UniProtKB=Q9NRX3 Q9NRX3 COXFA4L2 PTHR14256:SF5 NADH-UBIQUINONE OXIDOREDUCTASE MLRQ SUBUNIT CYTOCHROME C OXIDASE HYPOXIA ASSOCIATED SUBUNIT FA4L2 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=20910|UniProtKB=Q63HM1 Q63HM1 AFMID PTHR23024:SF574 ARYLACETAMIDE DEACETYLASE KYNURENINE FORMAMIDASE hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810 metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;carboxylic acid catabolic process#GO:0046395;indole-containing compound metabolic process#GO:0042430;cellular process#GO:0009987;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;small molecule catabolic process#GO:0044282;amino acid metabolic process#GO:0006520;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;proteinogenic amino acid metabolic process#GO:0170039 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 deacetylase#PC00087 HUMAN|Gene=YG024_HUMAN|UniProtKB=Q6ZRM9 Q6ZRM9 PTHR37553:SF6 DUF4705 DOMAIN-CONTAINING PROTEIN DUF4705 DOMAIN-CONTAINING PROTEIN HUMAN|HGNC=6383|UniProtKB=P01042 P01042 KNG1 PTHR13814:SF12 FETUIN KININOGEN-1 endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772;enzyme inhibitor activity#GO:0004857;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;cysteine-type endopeptidase inhibitor activity#GO:0004869;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;peptidase regulator activity#GO:0061134 regulation of response to stimulus#GO:0048583;regulation of response to stress#GO:0080134;negative regulation of cellular process#GO:0048523;negative regulation of blood coagulation#GO:0030195;negative regulation of response to wounding#GO:1903035;regulation of hemostasis#GO:1900046;regulation of response to wounding#GO:1903034;negative regulation of wound healing#GO:0061045;biological regulation#GO:0065007;negative regulation of response to external stimulus#GO:0032102;regulation of multicellular organismal process#GO:0051239;regulation of coagulation#GO:0050818;negative regulation of cell adhesion#GO:0007162;regulation of response to external stimulus#GO:0032101;negative regulation of response to stimulus#GO:0048585;regulation of cell adhesion#GO:0030155;negative regulation of hemostasis#GO:1900047;regulation of biological quality#GO:0065008;negative regulation of coagulation#GO:0050819;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of multicellular organismal process#GO:0051241;regulation of wound healing#GO:0061041;regulation of blood coagulation#GO:0030193;regulation of body fluid levels#GO:0050878;regulation of cellular process#GO:0050794 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease inhibitor#PC00191 Blood coagulation#P00011>Bradykinin#P00438;Blood coagulation#P00011>HMWK#P00413;Blood coagulation#P00011>Kininogen#P00451 HUMAN|HGNC=7013|UniProtKB=P50221 P50221 MEOX1 PTHR24328:SF8 HOMEOBOX PROTEIN MOX HOMEOBOX PROTEIN MOX-1 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;multicellular organismal process#GO:0032501;tissue development#GO:0009888;epithelium development#GO:0060429;regulation of nucleobase-containing compound metabolic process#GO:0019219;embryo development#GO:0009790;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;multicellular organism development#GO:0007275;regulation of gene expression#GO:0010468;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;animal gross anatomical part developmental process#GO:0160108;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of RNA metabolic process#GO:0051252 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 homeodomain transcription factor#PC00119 HUMAN|HGNC=20862|UniProtKB=Q9C0K1 Q9C0K1 SLC39A8 PTHR12191:SF2 SOLUTE CARRIER FAMILY 39 METAL CATION SYMPORTER ZIP8 solute:monoatomic cation symporter activity#GO:0015294;monoatomic ion transmembrane transporter activity#GO:0015075;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873;bicarbonate transmembrane transporter activity#GO:0015106;zinc ion transmembrane transporter activity#GO:0005385;secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic cation transmembrane transporter activity#GO:0008324;transition metal ion transmembrane transporter activity#GO:0046915;symporter activity#GO:0015293 import across plasma membrane#GO:0098739;inorganic ion import across plasma membrane#GO:0099587;metal ion transport#GO:0030001;homeostatic process#GO:0042592;intracellular monoatomic ion homeostasis#GO:0006873;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;transition metal ion transport#GO:0000041;zinc ion transmembrane transport#GO:0071577;zinc ion transport#GO:0006829;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;establishment of localization#GO:0051234;import into cell#GO:0098657;inorganic cation import across plasma membrane#GO:0098659;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;chemical homeostasis#GO:0048878;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227;secondary carrier transporter#PC00258 HUMAN|HGNC=8350|UniProtKB=Q8NGL2 Q8NGL2 OR5L1 PTHR48018:SF32 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5L1 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 biological regulation#GO:0065007;multicellular organismal process#GO:0032501;signal transduction#GO:0007165;cellular process#GO:0009987;system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;sensory perception of smell#GO:0007608;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;sensory perception#GO:0007600;nervous system process#GO:0050877;G protein-coupled receptor signaling pathway#GO:0007186 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=6346|UniProtKB=Q9Y4X4 Q9Y4X4 KLF12 PTHR23235:SF56 KRUEPPEL-LIKE TRANSCRIPTION FACTOR KRUEPPEL-LIKE FACTOR 12 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=23576|UniProtKB=Q86VS8 Q86VS8 HOOK3 PTHR18947:SF38 HOOK PROTEINS PROTEIN HOOK HOMOLOG 3 binding#GO:0005488;microtubule binding#GO:0008017;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515 supramolecular fiber organization#GO:0097435;microtubule cytoskeleton organization#GO:0000226;cellular localization#GO:0051641;localization#GO:0051179;cytoplasmic microtubule organization#GO:0031122;cellular component organization#GO:0016043;microtubule-based process#GO:0007017;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;transport#GO:0006810;intracellular transport#GO:0046907;cytoskeleton organization#GO:0007010;cytoskeleton-dependent intracellular transport#GO:0030705;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;organelle organization#GO:0006996 microtubule cytoskeleton#GO:0015630;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule organizing center#GO:0005815;centrosome#GO:0005813;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HUMAN|HGNC=3240|UniProtKB=Q06889 Q06889 EGR3 PTHR23235:SF78 KRUEPPEL-LIKE TRANSCRIPTION FACTOR EARLY GROWTH RESPONSE PROTEIN 3 RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=3095|UniProtKB=Q9NR20 Q9NR20 DYRK4 PTHR24058:SF136 DUAL SPECIFICITY PROTEIN KINASE DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 4 protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740 intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 protein modifying enzyme#PC00260 HUMAN|HGNC=1701|UniProtKB=P60033 P60033 CD81 PTHR19282:SF214 TETRASPANIN CD81 ANTIGEN cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HUMAN|HGNC=5196|UniProtKB=Q9Y663 Q9Y663 HS3ST3A1 PTHR10605:SF64 HEPARAN SULFATE SULFOTRANSFERASE HEPARAN SULFATE GLUCOSAMINE 3-O-SULFOTRANSFERASE 3A1 sulfotransferase activity#GO:0008146;transferase activity, transferring sulphur-containing groups#GO:0016782;catalytic activity#GO:0003824;transferase activity#GO:0016740 transferase#PC00220;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=21559|UniProtKB=Q9UJ04 Q9UJ04 TSPYL4 PTHR11875:SF33 TESTIS-SPECIFIC Y-ENCODED PROTEIN TESTIS-SPECIFIC Y-ENCODED-LIKE PROTEIN 4 protein binding#GO:0005515;binding#GO:0005488;chromatin binding#GO:0003682;histone binding#GO:0042393 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=9701|UniProtKB=Q00577 Q00577 PURA PTHR12611:SF2 PUR-TRANSCRIPTIONAL ACTIVATOR TRANSCRIPTIONAL ACTIVATOR PROTEIN PUR-ALPHA DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HUMAN|HGNC=31446|UniProtKB=Q8NCN2 Q8NCN2 ZBTB34 PTHR24399:SF42 ZINC FINGER AND BTB DOMAIN-CONTAINING ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 34 sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulator activity#GO:0140110;DNA-binding transcription repressor activity#GO:0001217;transcription regulatory region nucleic acid binding#GO:0001067 negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of cytokine production#GO:0001817;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of multicellular organismal process#GO:0051239;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;negative regulation of metabolic process#GO:0009892 nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218 HUMAN|HGNC=26737|UniProtKB=A0A1B0GTI8 A0A1B0GTI8 TMEM272 PTHR33444:SF7 SI:DKEY-19B23.12-RELATED TRANSMEMBRANE PROTEIN 272 HUMAN|HGNC=14269|UniProtKB=O43173 O43173 ST8SIA3 PTHR11987:SF36 ALPHA-2,8-SIALYLTRANSFERASE ALPHA-N-ACETYLNEURAMINATE ALPHA-2,8-SIALYLTRANSFERASE ST8SIA3 sialyltransferase activity#GO:0008373;glycosyltransferase activity#GO:0016757;transferase activity#GO:0016740;catalytic activity#GO:0003824 oligosaccharide metabolic process#GO:0009311;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;carbohydrate metabolic process#GO:0005975;biosynthetic process#GO:0009058;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;glycoprotein biosynthetic process#GO:0009101;protein N-linked glycosylation#GO:0006487;primary metabolic process#GO:0044238 metabolite interconversion enzyme#PC00262;transferase#PC00220 HUMAN|HGNC=4522|UniProtKB=P48145 P48145 NPBWR1 PTHR24229:SF47 NEUROPEPTIDES RECEPTOR NEUROPEPTIDES B_W RECEPTOR TYPE 1 molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;binding#GO:0005488;neuropeptide binding#GO:0042923;peptide binding#GO:0042277;transmembrane signaling receptor activity#GO:0004888 biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;neuropeptide signaling pathway#GO:0007218;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane#GO:0005886;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944 G-protein coupled receptor#PC00021 HUMAN|HGNC=2514|UniProtKB=P35222 P35222 CTNNB1 PTHR45976:SF4 ARMADILLO SEGMENT POLARITY PROTEIN CATENIN BETA-1 protein phosphatase binding#GO:0019903;transcription coactivator activity#GO:0003713;cell adhesion molecule binding#GO:0050839;transcription coregulator activity#GO:0003712;nuclear receptor binding#GO:0016922;transcription factor binding#GO:0008134;DNA-binding transcription factor binding#GO:0140297;protein binding#GO:0005515;RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629;enzyme binding#GO:0019899;transcription regulator activity#GO:0140110;phosphatase binding#GO:0019902;binding#GO:0005488 positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;cell adhesion#GO:0007155;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;cell surface receptor signaling pathway#GO:0007166;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of macromolecule metabolic process#GO:0010604;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;cell-cell adhesion#GO:0098609;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;cell communication#GO:0007154;canonical Wnt signaling pathway#GO:0060070;regulation of DNA-templated transcription#GO:0006355;positive regulation of RNA metabolic process#GO:0051254;Wnt signaling pathway#GO:0016055;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 adherens junction#GO:0005912;extrinsic component of membrane#GO:0019898;cell junction#GO:0030054;extrinsic component of plasma membrane#GO:0019897;cell periphery#GO:0071944;nucleus#GO:0005634;cell-cell junction#GO:0005911;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 p53 pathway feedback loops 2#P04398>beta-catenin#P04670;CCKR signaling map#P06959>beta-catenin#P07150;Gonadotropin-releasing hormone receptor pathway#P06664>CTNNB1#P06838;Cadherin signaling pathway#P00012>betacatenin#P00463;Wnt signaling pathway#P00057>Beta-Catenin#P01432;Angiogenesis#P00005>beta catenin#P00187;Alzheimer disease-presenilin pathway#P00004>beta-catenin#P00156 HUMAN|HGNC=8582|UniProtKB=P00439 P00439 PAH PTHR11473:SF44 AROMATIC AMINO ACID HYDROXYLASE PHENYLALANINE-4-HYDROXYLASE oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;monooxygenase activity#GO:0004497;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152;amino acid biosynthetic process#GO:0008652;proteinogenic amino acid biosynthetic process#GO:0170038;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;proteinogenic amino acid metabolic process#GO:0170039;oxoacid metabolic process#GO:0043436;carboxylic acid biosynthetic process#GO:0046394;aromatic amino acid biosynthetic process#GO:0009073;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;small molecule catabolic process#GO:0044282;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HUMAN|HGNC=21424|UniProtKB=Q96LB3 Q96LB3 IFT74 PTHR31432:SF0 INTRAFLAGELLAR TRANSPORT PROTEIN 74 HOMOLOG INTRAFLAGELLAR TRANSPORT PROTEIN 74 HOMOLOG binding#GO:0005488;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515 microtubule-based transport#GO:0099111;organelle assembly#GO:0070925;cilium organization#GO:0044782;cellular localization#GO:0051641;localization#GO:0051179;cellular component organization#GO:0016043;cilium assembly#GO:0060271;intraciliary transport#GO:0042073;microtubule-based movement#GO:0007018;cell projection organization#GO:0030030;transport#GO:0006810;intracellular transport#GO:0046907;plasma membrane bounded cell projection assembly#GO:0120031;microtubule-based process#GO:0007017;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;cell projection assembly#GO:0030031;intraciliary transport involved in cilium assembly#GO:0035735;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton-dependent intracellular transport#GO:0030705;cellular component assembly#GO:0022607 cilium#GO:0005929;intraciliary transport particle B#GO:0030992;intraciliary transport particle#GO:0030990;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 HUMAN|HGNC=7413|UniProtKB=Q13126 Q13126 MTAP PTHR42679:SF4 S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE glycosyltransferase activity#GO:0016757;pentosyltransferase activity#GO:0016763;catalytic activity#GO:0003824;transferase activity#GO:0016740 purine nucleoside metabolic process#GO:0042278;oxoacid metabolic process#GO:0043436;purine-containing compound metabolic process#GO:0072521;modified amino acid metabolic process#GO:0006575;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;small molecule metabolic process#GO:0044281;nucleoside metabolic process#GO:0009116;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative metabolic process#GO:1901135;homocysteine metabolic process#GO:0050667;cellular process#GO:0009987;sulfur compound metabolic process#GO:0006790;nucleobase-containing compound metabolic process#GO:0006139;amino acid metabolic process#GO:0006520;proteinogenic amino acid metabolic process#GO:0170039 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 nucleotide kinase#PC00172;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=26553|UniProtKB=Q96M34 Q96M34 TEX55 PTHR47110:SF1 TESTIS-SPECIFIC EXPRESSED PROTEIN 55 TESTIS-SPECIFIC EXPRESSED PROTEIN 55 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=15200|UniProtKB=Q9H343 Q9H343 OR51I1 PTHR26450:SF66 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 51I1 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=10642|UniProtKB=P42830 P42830 CXCL5 PTHR12015:SF197 SMALL INDUCIBLE CYTOKINE A C-X-C MOTIF CHEMOKINE 5 receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;chemokine activity#GO:0008009;G protein-coupled receptor binding#GO:0001664;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;binding#GO:0005488;signaling receptor binding#GO:0005102;cytokine receptor binding#GO:0005126;cytokine activity#GO:0005125;chemokine receptor binding#GO:0042379;protein binding#GO:0005515;molecular function activator activity#GO:0140677 cellular response to biotic stimulus#GO:0071216;cellular response to stimulus#GO:0051716;cell motility#GO:0048870;locomotion#GO:0040011;response to external biotic stimulus#GO:0043207;response to bacterium#GO:0009617;chemotaxis#GO:0006935;inflammatory response#GO:0006954;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;cell chemotaxis#GO:0060326;immune response#GO:0006955;cell migration#GO:0016477;response to other organism#GO:0051707;leukocyte migration#GO:0050900;cellular response to molecule of bacterial origin#GO:0071219;leukocyte chemotaxis#GO:0030595;defense response#GO:0006952;myeloid leukocyte migration#GO:0097529;response to external stimulus#GO:0009605;response to molecule of bacterial origin#GO:0002237;response to stimulus#GO:0050896;granulocyte chemotaxis#GO:0071621;biological process involved in interspecies interaction between organisms#GO:0044419;immune system process#GO:0002376;cellular response to chemical stimulus#GO:0070887;response to oxygen-containing compound#GO:1901700;cellular response to lipopolysaccharide#GO:0071222;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;cellular process#GO:0009987;defense response to symbiont#GO:0140546;cellular response to oxygen-containing compound#GO:1901701;granulocyte migration#GO:0097530;response to lipid#GO:0033993;defense response to other organism#GO:0098542;cellular response to lipid#GO:0071396;neutrophil migration#GO:1990266;response to chemical#GO:0042221;taxis#GO:0042330;humoral immune response#GO:0006959;antimicrobial humoral response#GO:0019730;neutrophil chemotaxis#GO:0030593;response to lipopolysaccharide#GO:0032496 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 cytokine#PC00083 HUMAN|HGNC=11395|UniProtKB=Q9UEE5 Q9UEE5 STK17A PTHR24342:SF6 SERINE/THREONINE-PROTEIN KINASE 17 SERINE_THREONINE-PROTEIN KINASE 17A transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of apoptotic process#GO:0043065;regulation of apoptotic process#GO:0042981;signaling#GO:0023052;positive regulation of programmed cell death#GO:0043068;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of programmed cell death#GO:0043067;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=17635|UniProtKB=Q9NZQ7 Q9NZQ7 CD274 PTHR25466:SF3 T-LYMPHOCYTE ACTIVATION ANTIGEN PROGRAMMED CELL DEATH 1 LIGAND 1 receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546 negative regulation of cell communication#GO:0010648;regulation of immune response#GO:0050776;regulation of signaling#GO:0023051;immune system process#GO:0002376;negative regulation of signaling#GO:0023057;regulation of cell communication#GO:0010646;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;negative regulation of immune system process#GO:0002683;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;negative regulation of response to stimulus#GO:0048585;immune response#GO:0006955 membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;plasma membrane#GO:0005886 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=52284|UniProtKB=H3BQJ8 H3BQJ8 LY6L PTHR32217:SF2 LYMPHOCYTE ANTIGEN 6H LYMPHOCYTE ANTIGEN 6L HUMAN|HGNC=4469|UniProtKB=P49685 P49685 GPR15 PTHR24228:SF10 B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR G PROTEIN-COUPLED RECEPTOR 15 G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 anatomical structure development#GO:0048856;angiogenesis#GO:0001525;cell communication#GO:0007154;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;G protein-coupled receptor signaling pathway#GO:0007186;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;circulatory system development#GO:0072359;signaling#GO:0023052;blood vessel morphogenesis#GO:0048514;tube morphogenesis#GO:0035239;cellular response to stimulus#GO:0051716;blood vessel development#GO:0001568;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;multicellular organism development#GO:0007275;vasculature development#GO:0001944;anatomical structure formation involved in morphogenesis#GO:0048646;developmental process#GO:0032502;multicellular organismal process#GO:0032501;tube development#GO:0035295;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=7230|UniProtKB=P49959 P49959 MRE11 PTHR10139:SF4 DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11 DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11 catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;DNA nuclease activity#GO:0004536;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on DNA#GO:0140097;endonuclease activity#GO:0004519;hydrolase activity#GO:0016787;DNA endonuclease activity#GO:0004520;nuclease activity#GO:0004518 meiosis I cell cycle process#GO:0061982;recombinational repair#GO:0000725;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;mitotic cell cycle checkpoint signaling#GO:0007093;nucleic acid metabolic process#GO:0090304;mitotic DNA damage checkpoint signaling#GO:0044773;mitotic cell cycle#GO:0000278;reproductive process#GO:0022414;DNA repair#GO:0006281;negative regulation of cell cycle process#GO:0010948;double-strand break repair via nonhomologous end joining#GO:0006303;telomere maintenance#GO:0000723;regulation of cell cycle G2/M phase transition#GO:1902749;DNA integrity checkpoint signaling#GO:0031570;mitotic G2/M transition checkpoint#GO:0044818;mitotic DNA integrity checkpoint signaling#GO:0044774;regulation of mitotic cell cycle#GO:0007346;DNA damage checkpoint signaling#GO:0000077;nucleobase-containing compound metabolic process#GO:0006139;cellular response to stress#GO:0033554;regulation of mitotic cell cycle phase transition#GO:1901990;negative regulation of mitotic cell cycle#GO:0045930;mitotic G2 DNA damage checkpoint signaling#GO:0007095;meiotic cell cycle process#GO:1903046;cellular component organization#GO:0016043;signaling#GO:0023052;metabolic process#GO:0008152;DNA recombination#GO:0006310;negative regulation of cell cycle#GO:0045786;double-strand break repair#GO:0006302;response to stress#GO:0006950;cell cycle checkpoint signaling#GO:0000075;negative regulation of G2/M transition of mitotic cell cycle#GO:0010972;regulation of cell cycle process#GO:0010564;sexual reproduction#GO:0019953;regulation of G2/M transition of mitotic cell cycle#GO:0010389;telomere organization#GO:0032200;cell cycle#GO:0007049;regulation of cell cycle phase transition#GO:1901987;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;negative regulation of cellular process#GO:0048523;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;mitotic cell cycle process#GO:1903047;chromosome organization#GO:0051276;biological regulation#GO:0065007;mitotic intra-S DNA damage checkpoint signaling#GO:0031573;negative regulation of biological process#GO:0048519;negative regulation of cell cycle phase transition#GO:1901988;signal transduction in response to DNA damage#GO:0042770;regulation of biological process#GO:0050789;double-strand break repair via homologous recombination#GO:0000724;cell cycle process#GO:0022402;response to stimulus#GO:0050896;regulation of cell cycle#GO:0051726;meiotic cell cycle#GO:0051321;DNA metabolic process#GO:0006259;cellular component organization or biogenesis#GO:0071840;negative regulation of cell cycle G2/M phase transition#GO:1902750;organelle organization#GO:0006996;meiotic DNA double-strand break formation#GO:0042138;signal transduction#GO:0007165;cellular process#GO:0009987;negative regulation of mitotic cell cycle phase transition#GO:1901991 intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;site of DNA damage#GO:0090734;membrane-bounded organelle#GO:0043227;chromosome#GO:0005694;site of double-strand break#GO:0035861;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232 HUMAN|HGNC=17760|UniProtKB=Q9NP99 Q9NP99 TREM1 PTHR19357:SF0 TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 1 TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 cellular response to stimulus#GO:0051716;response to external biotic stimulus#GO:0043207;locomotion#GO:0040011;cell motility#GO:0048870;chemotaxis#GO:0006935;response to bacterium#GO:0009617;cell chemotaxis#GO:0060326;response to other organism#GO:0051707;cell migration#GO:0016477;leukocyte migration#GO:0050900;cell killing#GO:0001906;response to external stimulus#GO:0009605;myeloid leukocyte migration#GO:0097529;defense response#GO:0006952;leukocyte chemotaxis#GO:0030595;leukocyte mediated cytotoxicity#GO:0001909;defense response to Gram-negative bacterium#GO:0050829;biological process involved in interspecies interaction between organisms#GO:0044419;granulocyte chemotaxis#GO:0071621;response to stimulus#GO:0050896;defense response to bacterium#GO:0042742;immune system process#GO:0002376;cellular response to chemical stimulus#GO:0070887;leukocyte mediated immunity#GO:0002443;cellular process#GO:0009987;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;neutrophil migration#GO:1990266;taxis#GO:0042330;response to chemical#GO:0042221;granulocyte migration#GO:0097530;immune effector process#GO:0002252;neutrophil chemotaxis#GO:0030593 cellular anatomical structure#GO:0110165;cell surface#GO:0009986 HUMAN|HGNC=18037|UniProtKB=Q68CP9 Q68CP9 ARID2 PTHR22970:SF14 AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2 AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2 nucleic acid binding#GO:0003676;binding#GO:0005488;DNA binding#GO:0003677 cellular component organization or biogenesis#GO:0071840;chromatin organization#GO:0006325;chromatin remodeling#GO:0006338;cellular component organization#GO:0016043;cellular process#GO:0009987 chromosome#GO:0005694;SWI/SNF superfamily-type complex#GO:0070603;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;ATPase complex#GO:1904949;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;chromatin#GO:0000785;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513 HUMAN|HGNC=25902|UniProtKB=Q8NAT1 Q8NAT1 POMGNT2 PTHR20961:SF167 GLYCOSYLTRANSFERASE PROTEIN O-LINKED-MANNOSE BETA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE 2 acetylglucosaminyltransferase activity#GO:0008375;glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194;catalytic activity, acting on a protein#GO:0140096;hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;glycoprotein metabolic process#GO:0009100;protein O-linked glycosylation via mannose#GO:0035269;metabolic process#GO:0008152;biosynthetic process#GO:0009058;carbohydrate derivative metabolic process#GO:1901135;protein O-linked glycosylation#GO:0006493;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;glycosyltransferase#PC00111 HUMAN|HGNC=23383|UniProtKB=Q9HCK0 Q9HCK0 ZBTB26 PTHR24399:SF14 ZINC FINGER AND BTB DOMAIN-CONTAINING ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 26 transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription repressor activity#GO:0001217;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837 negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of cytokine production#GO:0001817;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of multicellular organismal process#GO:0051239;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974 C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218 HUMAN|HGNC=2577|UniProtKB=P13498 P13498 CYBA PTHR15168:SF0 CYTOCHROME B-245 LIGHT CHAIN CYTOCHROME B-245 LIGHT CHAIN oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor#GO:0050664;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on NAD(P)H#GO:0016651 response to stimulus#GO:0050896;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;immune system process#GO:0002376;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;defense response to symbiont#GO:0140546;immune response#GO:0006955;cellular process#GO:0009987;defense response to other organism#GO:0098542;response to other organism#GO:0051707;metabolic process#GO:0008152;reactive oxygen species metabolic process#GO:0072593;superoxide metabolic process#GO:0006801;innate immune response#GO:0045087;response to external stimulus#GO:0009605;defense response#GO:0006952 catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;oxidoreductase complex#GO:1990204;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944 HUMAN|HGNC=12770|UniProtKB=O76076 O76076 CCN5 PTHR11348:SF22 CONNECTIVE TISSUE GROWTH FACTOR-RELATED CCN FAMILY MEMBER 5 protein-containing complex binding#GO:0044877;protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102;glycosaminoglycan binding#GO:0005539;integrin binding#GO:0005178;heparin binding#GO:0008201;cell adhesion molecule binding#GO:0050839;carbohydrate derivative binding#GO:0097367 cell adhesion#GO:0007155;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of developmental process#GO:0050793;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of cell differentiation#GO:0045595;positive regulation of cell differentiation#GO:0045597;positive regulation of developmental process#GO:0051094;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;biological regulation#GO:0065007 external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207;growth factor#PC00112 HUMAN|HGNC=10520|UniProtKB=Q15424 Q15424 SAFB PTHR15683:SF9 SCAFFOLD ATTACHMENT FACTOR B-RELATED SCAFFOLD ATTACHMENT FACTOR B1 nucleic acid binding#GO:0003676;binding#GO:0005488;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565 cellular response to steroid hormone stimulus#GO:0071383;cellular process#GO:0009987;nuclear receptor-mediated steroid hormone signaling pathway#GO:0030518;signal transduction#GO:0007165;response to hormone#GO:0009725;biological regulation#GO:0065007;cellular response to lipid#GO:0071396;response to lipid#GO:0033993;response to chemical#GO:0042221;nuclear receptor-mediated signaling pathway#GO:0141193;response to steroid hormone#GO:0048545;cellular response to chemical stimulus#GO:0070887;intracellular signal transduction#GO:0035556;hormone-mediated signaling pathway#GO:0009755;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;steroid hormone receptor signaling pathway#GO:0043401;estrogen receptor signaling pathway#GO:0030520;response to endogenous stimulus#GO:0009719;intracellular receptor signaling pathway#GO:0030522;signaling#GO:0023052;regulation of cellular process#GO:0050794;cellular response to hormone stimulus#GO:0032870;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=8910|UniProtKB=P06401 P06401 PGR PTHR48092:SF6 KNIRPS-RELATED PROTEIN-RELATED PROGESTERONE RECEPTOR sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;molecular transducer activity#GO:0060089;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;nuclear receptor activity#GO:0004879;sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023;transcription regulator activity#GO:0140110;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulatory region nucleic acid binding#GO:0001067 cellular response to chemical stimulus#GO:0070887;hormone-mediated signaling pathway#GO:0009755;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;signaling#GO:0023052;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;cellular response to hormone stimulus#GO:0032870;cellular response to steroid hormone stimulus#GO:0071383;signal transduction#GO:0007165;cellular process#GO:0009987;response to hormone#GO:0009725;response to chemical#GO:0042221;response to lipid#GO:0033993;cellular response to lipid#GO:0071396;response to steroid hormone#GO:0048545;intracellular signal transduction#GO:0035556;regulation of RNA metabolic process#GO:0051252;cell communication#GO:0007154;regulation of DNA-templated transcription#GO:0006355;steroid hormone receptor signaling pathway#GO:0043401;cellular response to stimulus#GO:0051716;intracellular receptor signaling pathway#GO:0030522;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;nuclear receptor-mediated steroid hormone signaling pathway#GO:0030518;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;nuclear receptor-mediated signaling pathway#GO:0141193 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226 zinc finger transcription factor#PC00244;C4 zinc finger nuclear receptor#PC00169 Gonadotropin-releasing hormone receptor pathway#P06664>PR#P06708 HUMAN|HGNC=18290|UniProtKB=Q8NFW8 Q8NFW8 CMAS PTHR21485:SF3 HAD SUPERFAMILY MEMBERS CMAS AND KDSC N-ACYLNEURAMINATE CYTIDYLYLTRANSFERASE catalytic activity#GO:0003824;transferase activity#GO:0016740;nucleotidyltransferase activity#GO:0016779;transferase activity, transferring phosphorus-containing groups#GO:0016772 transferase#PC00220;nucleotidyltransferase#PC00174 HUMAN|HGNC=18326|UniProtKB=Q96QA6 Q96QA6 YPEL2 PTHR13848:SF3 PROTEIN YIPPEE-LIKE CG15309-RELATED PROTEIN YIPPEE-LIKE 2 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=28912|UniProtKB=Q9Y484 Q9Y484 WDR45 PTHR11227:SF44 WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED WD REPEAT DOMAIN PHOSPHOINOSITIDE-INTERACTING PROTEIN 4 lipid binding#GO:0008289;phosphatidylinositol bisphosphate binding#GO:1902936;protein-macromolecule adaptor activity#GO:0030674;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;anion binding#GO:0043168;phosphatidylinositol-3-phosphate binding#GO:0032266;phosphatidylinositol phosphate binding#GO:1901981;molecular adaptor activity#GO:0060090;phospholipid binding#GO:0005543 cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;autophagy#GO:0006914;cellular process#GO:0009987;autophagosome organization#GO:1905037;cellular component assembly#GO:0022607;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;cellular component organization or biogenesis#GO:0071840;autophagosome assembly#GO:0000045;glucan metabolic process#GO:0044042;cellular component organization#GO:0016043;polysaccharide catabolic process#GO:0000272;polysaccharide metabolic process#GO:0005976;glucan catabolic process#GO:0009251;carbohydrate catabolic process#GO:0016052;process utilizing autophagic mechanism#GO:0061919;macromolecule localization#GO:0033036;glycogen catabolic process#GO:0005980;macroautophagy#GO:0016236;autophagy of mitochondrion#GO:0000422;generation of precursor metabolites and energy#GO:0006091;pexophagy#GO:0000425;macromolecule metabolic process#GO:0043170;energy derivation by oxidation of organic compounds#GO:0015980;intracellular protein localization#GO:0008104;glycogen metabolic process#GO:0005977;primary metabolic process#GO:0044238;catabolic process#GO:0009056;carbohydrate metabolic process#GO:0005975;organelle assembly#GO:0070925;energy reserve metabolic process#GO:0006112;localization#GO:0051179;vacuole organization#GO:0007033 membrane#GO:0016020;phagophore assembly site#GO:0000407;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 scaffold/adaptor protein#PC00226 HUMAN|HGNC=18809|UniProtKB=P68363 P68363 TUBA1B PTHR11588:SF251 TUBULIN TUBULIN ALPHA-1B CHAIN guanyl nucleotide binding#GO:0019001;structural constituent of cytoskeleton#GO:0005200;binding#GO:0005488;nucleoside phosphate binding#GO:1901265;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;ribonucleotide binding#GO:0032553;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;small molecule binding#GO:0036094;anion binding#GO:0043168;ion binding#GO:0043167;nucleotide binding#GO:0000166;structural molecule activity#GO:0005198 generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;microtubule cytoskeleton organization#GO:0000226;anatomical structure development#GO:0048856;cell cycle#GO:0007049;cellular component organization#GO:0016043;cell differentiation#GO:0030154;mitotic cell cycle#GO:0000278;neuron differentiation#GO:0030182;developmental process#GO:0032502;neurogenesis#GO:0022008;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;cellular process#GO:0009987;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;nervous system development#GO:0007399;multicellular organismal process#GO:0032501 intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;microtubule#GO:0005874;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;organelle#GO:0043226;supramolecular complex#GO:0099080;microtubule cytoskeleton#GO:0015630 tubulin#PC00228;cytoskeletal protein#PC00085 Gonadotropin-releasing hormone receptor pathway#P06664>Tubulin#P06772 HUMAN|HGNC=9723|UniProtKB=P11216 P11216 PYGB PTHR11468:SF29 GLYCOGEN PHOSPHORYLASE GLYCOGEN PHOSPHORYLASE, BRAIN FORM transferase activity#GO:0016740;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;glycosyltransferase activity#GO:0016757 primary metabolic process#GO:0044238;glucan metabolic process#GO:0044042;glycogen metabolic process#GO:0005977;polysaccharide catabolic process#GO:0000272;polysaccharide metabolic process#GO:0005976;catabolic process#GO:0009056;glucan catabolic process#GO:0009251;carbohydrate metabolic process#GO:0005975;energy reserve metabolic process#GO:0006112;carbohydrate catabolic process#GO:0016052;glycogen catabolic process#GO:0005980;cellular process#GO:0009987;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091;energy derivation by oxidation of organic compounds#GO:0015980;macromolecule metabolic process#GO:0043170 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 transferase#PC00220;glycosyltransferase#PC00111 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Phosphorylase b#P00717;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Phosphorylase a#P00718 HUMAN|HGNC=30212|UniProtKB=Q9HCD6 Q9HCD6 TANC2 PTHR24166:SF21 ROLLING PEBBLES, ISOFORM B PROTEIN TANC2 structural molecule activity#GO:0005198;structural constituent of synapse#GO:0098918 regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of developmental process#GO:0050793;biological regulation#GO:0065007;regulation of postsynapse organization#GO:0099175;regulation of biological process#GO:0050789;regulation of neuron projection development#GO:0010975;regulation of anatomical structure morphogenesis#GO:0022603;regulation of synapse structure or activity#GO:0050803;regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of biological quality#GO:0065008;regulation of cell projection organization#GO:0031344;regulation of synapse organization#GO:0050807;regulation of dendritic spine morphogenesis#GO:0061001 plasma membrane bounded cell projection#GO:0120025;neuron spine#GO:0044309;cell projection#GO:0042995;somatodendritic compartment#GO:0036477;synapse#GO:0045202;cellular anatomical structure#GO:0110165;dendritic spine#GO:0043197;neuron projection#GO:0043005;postsynapse#GO:0098794;cell junction#GO:0030054;dendritic tree#GO:0097447;dendrite#GO:0030425 scaffold/adaptor protein#PC00226 HUMAN|HGNC=20644|UniProtKB=Q8TED4 Q8TED4 SLC37A2 PTHR43184:SF9 MAJOR FACILITATOR SUPERFAMILY TRANSPORTER 16, ISOFORM B GLUCOSE-6-PHOSPHATE EXCHANGER SLC37A2 carbohydrate derivative transmembrane transporter activity#GO:1901505;organophosphate ester transmembrane transporter activity#GO:0015605;phosphate transmembrane transporter activity#GO:0005315;active transmembrane transporter activity#GO:0022804;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;antiporter activity#GO:0015297 inorganic anion transport#GO:0015698;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810;phosphate ion transport#GO:0006817;organophosphate ester transport#GO:0015748;cellular process#GO:0009987;carbohydrate derivative transport#GO:1901264 endoplasmic reticulum membrane#GO:0005789;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane#GO:0016020;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 transporter#PC00227 HUMAN|HGNC=11011|UniProtKB=Q9UGQ3 Q9UGQ3 SLC2A6 PTHR48021:SF59 FAMILY NOT NAMED SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 6 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;membrane#GO:0016020 HUMAN|HGNC=28771|UniProtKB=Q9BVC6 Q9BVC6 TMEM109 PTHR14550:SF2 TRANSMEMBRANE PROTEIN 109 VOLTAGE-GATED MONOATOMIC CATION CHANNEL TMEM109 DNA damage response#GO:0006974;apoptotic signaling pathway#GO:0097190;cellular response to abiotic stimulus#GO:0071214;intrinsic apoptotic signaling pathway in response to DNA damage#GO:0008630;response to stress#GO:0006950;signal transduction#GO:0007165;response to radiation#GO:0009314;cellular process#GO:0009987;biological regulation#GO:0065007;signal transduction by p53 class mediator#GO:0072331;cellular response to stress#GO:0033554;cell communication#GO:0007154;intrinsic apoptotic signaling pathway#GO:0097193;intracellular signal transduction#GO:0035556;intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator#GO:0042771;programmed cell death#GO:0012501;response to abiotic stimulus#GO:0009628;response to ionizing radiation#GO:0010212;regulation of biological process#GO:0050789;apoptotic process#GO:0006915;cell death#GO:0008219;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;intrinsic apoptotic signaling pathway by p53 class mediator#GO:0072332;regulation of cellular process#GO:0050794;cellular response to environmental stimulus#GO:0104004;signaling#GO:0023052;cellular response to radiation#GO:0071478 HUMAN|HGNC=19689|UniProtKB=Q7Z3Z2 Q7Z3Z2 RD3 PTHR28489:SF1 RENTINAL DEGENERATION 3-LIKE PROTEIN RD3 visual system development#GO:0150063;retina development in camera-type eye#GO:0060041;multicellular organismal process#GO:0032501;sensory system development#GO:0048880;system development#GO:0048731;eye development#GO:0001654;multicellular organism development#GO:0007275;anatomical structure development#GO:0048856;animal organ development#GO:0048513;developmental process#GO:0032502;sensory organ development#GO:0007423;camera-type eye development#GO:0043010;animal gross anatomical part developmental process#GO:0160108 HUMAN|HGNC=33856|UniProtKB=A6ND91 A6ND91 ASPDH PTHR31873:SF6 L-ASPARTATE DEHYDROGENASE-RELATED ASPARTATE DEHYDROGENASE DOMAIN-CONTAINING PROTEIN dehydrogenase#PC00092 HUMAN|HGNC=18584|UniProtKB=Q8IU57 Q8IU57 IFNLR1 PTHR20859:SF55 INTERFERON/INTERLEUKIN RECEPTOR INTERFERON LAMBDA RECEPTOR 1 transmembrane signaling receptor activity#GO:0004888;cytokine receptor activity#GO:0004896;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;immune receptor activity#GO:0140375 cytokine-mediated signaling pathway#GO:0019221;cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;response to peptide#GO:1901652;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;regulation of cellular process#GO:0050794;response to cytokine#GO:0034097;response to stimulus#GO:0050896;response to chemical#GO:0042221;biological regulation#GO:0065007;signaling#GO:0023052 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=8783|UniProtKB=Q08499 Q08499 PDE4D PTHR11347:SF91 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 3',5'-CYCLIC-AMP PHOSPHODIESTERASE 4D cyclic-nucleotide phosphodiesterase activity#GO:0004112;phosphoric ester hydrolase activity#GO:0042578;phosphoric diester hydrolase activity#GO:0008081;hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;negative regulation of cellular process#GO:0048523;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;negative regulation of response to stimulus#GO:0048585;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cell communication#GO:0010646;negative regulation of signal transduction#GO:0009968;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789 phosphodiesterase#PC00185;hydrolase#PC00121 HUMAN|HGNC=8277|UniProtKB=O43869 O43869 OR2T1 PTHR26453:SF125 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2T1 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 nervous system process#GO:0050877;sensory perception#GO:0007600;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;system process#GO:0003008;detection of chemical stimulus#GO:0009593;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;response to stimulus#GO:0050896;response to chemical#GO:0042221 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=14868|UniProtKB=O95236 O95236 APOL3 PTHR14096:SF40 APOLIPOPROTEIN L APOLIPOPROTEIN L3 binding#GO:0005488;lipid binding#GO:0008289 membrane#GO:0016020;cellular anatomical structure#GO:0110165 apolipoprotein#PC00052;transfer/carrier protein#PC00219 HUMAN|HGNC=30777|UniProtKB=Q96GN5 Q96GN5 CDCA7L PTHR31169:SF4 OS05G0300700 PROTEIN CELL DIVISION CYCLE-ASSOCIATED 7-LIKE PROTEIN intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=25191|UniProtKB=Q8NFR7 Q8NFR7 CCDC148 PTHR21549:SF1 MUTATED IN BLADDER CANCER 1 COILED-COIL DOMAIN-CONTAINING PROTEIN 148 HUMAN|HGNC=9647|UniProtKB=Q15678 Q15678 PTPN14 PTHR45706:SF6 TYROSINE-PROTEIN PHOSPHATASE TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 14 phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725 regulation of intracellular signal transduction#GO:1902531;animal gross anatomical part developmental process#GO:0160108;regulation of signaling#GO:0023051;anatomical structure development#GO:0048856;positive regulation of signaling#GO:0023056;system development#GO:0048731;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;circulatory system development#GO:0072359;regulation of cell communication#GO:0010646;regulation of hippo signaling#GO:0035330;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;developmental process#GO:0032502;multicellular organism development#GO:0007275;vasculature development#GO:0001944;anatomical structure formation involved in morphogenesis#GO:0048646;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;multicellular organismal process#GO:0032501;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966 protein phosphatase#PC00195 HUMAN|HGNC=9498|UniProtKB=P07602 P07602 PSAP PTHR11480:SF107 SAPOSIN-RELATED PROSAPOSIN lipid binding#GO:0008289;binding#GO:0005488;antigen binding#GO:0003823 developmental process#GO:0032502;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;lipid metabolic process#GO:0006629;growth#GO:0040007;metabolic process#GO:0008152;adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway#GO:0007193;multicellular organism development#GO:0007275;developmental growth#GO:0048589;animal organ development#GO:0048513;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;G protein-coupled receptor signaling pathway#GO:0007186;animal gross anatomical part developmental process#GO:0160108;regulation of lipid metabolic process#GO:0019216;system development#GO:0048731;reproductive system development#GO:0061458;cell communication#GO:0007154;anatomical structure development#GO:0048856;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;developmental process involved in reproduction#GO:0003006;signaling#GO:0023052;reproductive process#GO:0022414;reproductive structure development#GO:0048608;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 lysosome#GO:0005764;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;vacuole#GO:0005773;cellular anatomical structure#GO:0110165;organelle#GO:0043226;extracellular region#GO:0005576;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;lytic vacuole#GO:0000323 scaffold/adaptor protein#PC00226 HUMAN|HGNC=11654|UniProtKB=Q13428 Q13428 TCOF1 PTHR20787:SF10 TREACLE TREACLE PROTEIN protein binding#GO:0005515;binding#GO:0005488 nucleolar large rRNA transcription by RNA polymerase I#GO:0042790;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;rRNA transcription#GO:0009303;transcription by RNA polymerase I#GO:0006360;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187 organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031 HUMAN|HGNC=26481|UniProtKB=Q68D06 Q68D06 SLFN13 PTHR12155:SF43 SCHLAFEN SCHLAFEN FAMILY MEMBER 13 nucleic acid binding#GO:0003676;binding#GO:0005488;tRNA binding#GO:0000049;RNA binding#GO:0003723 defense response#GO:0006952;response to external stimulus#GO:0009605;response to virus#GO:0009615;response to other organism#GO:0051707;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;defense response to virus#GO:0051607 endoribonuclease#PC00094 HUMAN|HGNC=30141|UniProtKB=Q96Q83 Q96Q83 ALKBH3 PTHR31212:SF4 ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3 ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3 primary metabolic process#GO:0044238;response to stress#GO:0006950;nucleic acid metabolic process#GO:0090304;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170 organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 oxidoreductase#PC00176;oxygenase#PC00177 HUMAN|HGNC=4490|UniProtKB=Q9UPC5 Q9UPC5 GPR34 PTHR24233:SF1 P2Y PURINOCEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR G PROTEIN-COUPLED RECEPTOR 34-RELATED transmembrane signaling receptor activity#GO:0004888;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=14973|UniProtKB=Q9Y5X1 Q9Y5X1 SNX9 PTHR45827:SF2 SORTING NEXIN SORTING NEXIN-9 binding#GO:0005488;anion binding#GO:0043168;phosphatidylinositol binding#GO:0035091;small molecule binding#GO:0036094;ion binding#GO:0043167 cellular localization#GO:0051641;cytoskeleton-dependent cytokinesis#GO:0061640;localization#GO:0051179;plasma membrane organization#GO:0007009;cytokinetic process#GO:0032506;cytokinesis#GO:0000910;endocytosis#GO:0006897;cell division#GO:0051301;cell cycle process#GO:0022402;cellular component organization#GO:0016043;cell cycle#GO:0007049;endosomal transport#GO:0016197;import into cell#GO:0098657;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;transport#GO:0006810;membrane invagination#GO:0010324;intracellular transport#GO:0046907;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular vesicle#GO:0097708;membrane#GO:0016020;vesicle#GO:0031982;cell periphery#GO:0071944;organelle#GO:0043226;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 scaffold/adaptor protein#PC00226 HUMAN|HGNC=16288|UniProtKB=Q9C026 Q9C026 TRIM9 PTHR24099:SF13 E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED E3 UBIQUITIN-PROTEIN LIGASE TRIM9 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=10382|UniProtKB=P04844 P04844 RPN2 PTHR12640:SF0 RIBOPHORIN II DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 2 glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;glycoprotein biosynthetic process#GO:0009101;protein N-linked glycosylation#GO:0006487;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058 cytoplasm#GO:0005737;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;membrane#GO:0016020;organelle membrane#GO:0031090;endoplasmic reticulum protein-containing complex#GO:0140534;endoplasmic reticulum#GO:0005783;transferase complex#GO:1990234;endoplasmic reticulum membrane#GO:0005789;intracellular membrane-bounded organelle#GO:0043231;oligosaccharyltransferase complex#GO:0008250;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;membrane protein complex#GO:0098796;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;catalytic complex#GO:1902494;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229 metabolite interconversion enzyme#PC00262;glycosyltransferase#PC00111 HUMAN|HGNC=22942|UniProtKB=Q9UQP3 Q9UQP3 TNN PTHR19143:SF348 FIBRINOGEN/TENASCIN/ANGIOPOEITIN TENASCIN-N binding#GO:0005488;signaling receptor binding#GO:0005102;cell adhesion molecule binding#GO:0050839;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;integrin binding#GO:0005178 animal gross anatomical part developmental process#GO:0160108;cell-matrix adhesion#GO:0007160;cell adhesion#GO:0007155;generation of neurons#GO:0048699;neuron projection extension#GO:1990138;developmental growth involved in morphogenesis#GO:0060560;neuron development#GO:0048666;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell development#GO:0048468;growth#GO:0040007;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;cell growth#GO:0016049;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cell projection morphogenesis#GO:0048858;neuron projection development#GO:0031175;cellular process#GO:0009987;nervous system development#GO:0007399;anatomical structure development#GO:0048856;cell-substrate adhesion#GO:0031589;system development#GO:0048731;developmental cell growth#GO:0048588;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;cellular developmental process#GO:0048869;developmental growth#GO:0048589;neurogenesis#GO:0022008;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HUMAN|HGNC=30520|UniProtKB=Q96BQ5 Q96BQ5 CCDC127 PTHR31958:SF2 COILED-COIL DOMAIN-CONTAINING PROTEIN 127 COILED-COIL DOMAIN-CONTAINING PROTEIN 127 HUMAN|HGNC=15521|UniProtKB=Q9NZI2 Q9NZI2 KCNIP1 PTHR23055:SF82 CALCIUM BINDING PROTEINS A-TYPE POTASSIUM CHANNEL MODULATORY PROTEIN KCNIP1 molecular function regulator activity#GO:0098772;ion channel regulator activity#GO:0099106;cation binding#GO:0043169;channel regulator activity#GO:0016247;protein binding#GO:0005515;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;transmembrane transporter binding#GO:0044325;potassium channel regulator activity#GO:0015459;transporter regulator activity#GO:0141108;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094 regulation of monoatomic cation transmembrane transport#GO:1904062;regulation of localization#GO:0032879;regulation of transport#GO:0051049;regulation of biological process#GO:0050789;regulation of monoatomic ion transmembrane transport#GO:0034765;regulation of transmembrane transport#GO:0034762;biological regulation#GO:0065007;regulation of monoatomic ion transport#GO:0043269;regulation of metal ion transport#GO:0010959;regulation of cellular process#GO:0050794 plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;cation channel complex#GO:0034703;voltage-gated potassium channel complex#GO:0008076;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351 calmodulin-related#PC00061 HUMAN|HGNC=4643|UniProtKB=O43708 O43708 GSTZ1 PTHR42673:SF24 MALEYLACETOACETATE ISOMERASE MALEYLACETOACETATE ISOMERASE cis-trans isomerase activity#GO:0016859;isomerase activity#GO:0016853;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;glutathione transferase activity#GO:0004364;transferase activity#GO:0016740;catalytic activity#GO:0003824 oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;glutathione metabolic process#GO:0006749;small molecule catabolic process#GO:0044282;amino acid metabolic process#GO:0006520;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;proteinogenic amino acid metabolic process#GO:0170039;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;sulfur compound metabolic process#GO:0006790;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;modified amino acid metabolic process#GO:0006575 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 isomerase#PC00135 HUMAN|HGNC=52382|UniProtKB=A0A1B0GTY4 A0A1B0GTY4 TEX50 PTHR39232:SF1 TESTIS-EXPRESSED PROTEIN 50 TESTIS-EXPRESSED PROTEIN 50 HUMAN|HGNC=30792|UniProtKB=O60739 O60739 EIF1B PTHR10388:SF51 EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1 EUKARYOTIC TRANSLATION INITIATION FACTOR 1B protein-containing complex binding#GO:0044877;ribosome binding#GO:0043022;ribonucleoprotein complex binding#GO:0043021;RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;translation initiation factor activity#GO:0003743;translation factor activity#GO:0180051 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904 translation initiation factor#PC00224 HUMAN|HGNC=13361|UniProtKB=Q9NQ76 Q9NQ76 MEPE PTHR16510:SF4 EXTRACELLULAR MATRIX PHOSPHOGLYCOPROTEIN WITH ASARM MOTIF MATRIX EXTRACELLULAR PHOSPHOGLYCOPROTEIN binding#GO:0005488;protein binding#GO:0005515 anatomical structure development#GO:0048856;tissue development#GO:0009888;animal organ development#GO:0048513;biomineral tissue development#GO:0031214;developmental process#GO:0032502;animal gross anatomical part developmental process#GO:0160108 extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cellular anatomical structure#GO:0110165 HUMAN|HGNC=23522|UniProtKB=Q5VUB5 Q5VUB5 FAM171A1 PTHR31626:SF1 SUSHI DOMAIN-CONTAINING PROTEIN PROTEIN FAM171A1 actin filament organization#GO:0007015;regulation of anatomical structure morphogenesis#GO:0022603;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;contractile actin filament bundle assembly#GO:0030038;cellular component assembly#GO:0022607;actin filament-based process#GO:0030029;regulation of biological quality#GO:0065008;supramolecular fiber organization#GO:0097435;stress fiber assembly#GO:0043149;actin filament bundle organization#GO:0061572;regulation of cell shape#GO:0008360;regulation of biological process#GO:0050789;actin filament bundle assembly#GO:0051017;cellular component organization#GO:0016043;actomyosin structure organization#GO:0031032;regulation of developmental process#GO:0050793;actin cytoskeleton organization#GO:0030036 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=1784|UniProtKB=P38936 P38936 CDKN1A PTHR46778:SF1 CYCLIN-DEPENDENT KINASE INHIBITOR 1-RELATED CYCLIN-DEPENDENT KINASE INHIBITOR 1 enzyme inhibitor activity#GO:0004857;kinase inhibitor activity#GO:0019210;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;protein kinase inhibitor activity#GO:0004860;protein kinase regulator activity#GO:0019887;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678 DNA damage response#GO:0006974;regulation of mitotic cell cycle#GO:0007346;cellular process#GO:0009987;response to stress#GO:0006950;biological regulation#GO:0065007;regulation of cell cycle process#GO:0010564;regulation of G1/S transition of mitotic cell cycle#GO:2000045;cellular response to stress#GO:0033554;regulation of mitotic cell cycle phase transition#GO:1901990;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cell cycle phase transition#GO:1901987;regulation of cell cycle G1/S phase transition#GO:1902806;regulation of cell cycle#GO:0051726;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular organelle#GO:0043229;transferase complex#GO:1990234;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;protein kinase complex#GO:1902911;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227 kinase inhibitor#PC00139 Interleukin signaling pathway#P00036>p21CIP1#P00993;p53 pathway feedback loops 2#P04398>P21#G04712;p53 pathway#P00059>P21#P04631;p53 pathway#P00059>p21#G01580;p53 pathway feedback loops 2#P04398>p21#P04667 HUMAN|HGNC=28542|UniProtKB=Q8N4F4 Q8N4F4 SLC22A24 PTHR24064:SF591 SOLUTE CARRIER FAMILY 22 MEMBER STEROID TRANSMEMBRANE TRANSPORTER SLC22A24 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 transport#GO:0006810;cellular process#GO:0009987;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 secondary carrier transporter#PC00258 HUMAN|HGNC=6850|UniProtKB=Q16584 Q16584 MAP3K11 PTHR44329:SF46 SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 11 protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;MAP kinase kinase kinase activity#GO:0004709;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740 microtubule-based process#GO:0007017;intracellular signal transduction#GO:0035556;MAPK cascade#GO:0000165;cell communication#GO:0007154;signaling#GO:0023052;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124;response to stimulus#GO:0050896;JNK cascade#GO:0007254;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 microtubule cytoskeleton#GO:0015630;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;centrosome#GO:0005813;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 CCKR signaling map#P06959>MAP3K11#P07139;Gonadotropin-releasing hormone receptor pathway#P06664>MAP3Ks#P06834 HUMAN|HGNC=9467|UniProtKB=O60256 O60256 PRPSAP2 PTHR10210:SF29 RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER PHOSPHORIBOSYL PYROPHOSPHATE SYNTHASE-ASSOCIATED PROTEIN 2 catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;nucleotide biosynthetic process#GO:0009165;organophosphate biosynthetic process#GO:0090407;nucleotide metabolic process#GO:0009117;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;ribose phosphate biosynthetic process#GO:0046390;organophosphate metabolic process#GO:0019637;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative biosynthetic process#GO:1901137;nucleoside phosphate biosynthetic process#GO:1901293 catalytic complex#GO:1902494;transferase complex#GO:1990234;transferase complex, transferring phosphorus-containing groups#GO:0061695;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;nucleotide kinase#PC00172 HUMAN|HGNC=8768|UniProtKB=O95831 O95831 AIFM1 PTHR43557:SF4 APOPTOSIS-INDUCING FACTOR 1 APOPTOSIS-INDUCING FACTOR 1, MITOCHONDRIAL catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;heterocyclic compound binding#GO:1901363;nucleotide binding#GO:0000166;oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor#GO:0050664;binding#GO:0005488;anion binding#GO:0043168;small molecule binding#GO:0036094;flavin adenine dinucleotide binding#GO:0050660;ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265;oxidoreductase activity, acting on NAD(P)H#GO:0016651 programmed cell death#GO:0012501;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;apoptotic process#GO:0006915;cell death#GO:0008219;mitochondrial transport#GO:0006839;mitochondrial protein import pathway#GO:7770058;intracellular transport#GO:0046907;transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 oxidoreductase#PC00176 Apoptosis signaling pathway#P00006>AIF#P00286 HUMAN|HGNC=3454|UniProtKB=Q14264 Q14264 ERV3-1 PTHR10424:SF68 VIRAL ENVELOPE PROTEIN ENDOGENOUS RETROVIRUS GROUP 3 MEMBER 1 ENV POLYPROTEIN striated muscle cell differentiation#GO:0051146;anatomical structure development#GO:0048856;cellular developmental process#GO:0048869;syncytium formation by cell-cell fusion#GO:0000768;developmental process#GO:0032502;animal gross anatomical part developmental process#GO:0160108;cell-cell fusion#GO:0140253;muscle structure development#GO:0061061;cell differentiation#GO:0030154;cellular process#GO:0009987;muscle cell differentiation#GO:0042692;myoblast fusion#GO:0007520 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 viral or transposable element protein#PC00237 HUMAN|HGNC=31999|UniProtKB=A0A087WUL8 A0A087WUL8 NBPF19 PTHR14199:SF35 NEUROBLASTOMA BREAKPOINT FAMILY MEMBER 6-LIKE PROTEIN NBPF FAMILY MEMBER NBPF1-RELATED HUMAN|HGNC=8059|UniProtKB=Q14980 Q14980 NUMA1 PTHR18902:SF24 NUCLEAR MITOTIC APPARATUS PROTEIN 1-RELATED NUCLEAR MITOTIC APPARATUS PROTEIN 1 binding#GO:0005488;microtubule binding#GO:0008017;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515 establishment or maintenance of cell polarity#GO:0007163;organelle localization#GO:0051640;localization#GO:0051179;microtubule cytoskeleton organization#GO:0000226;cellular localization#GO:0051641;spindle localization#GO:0051653;regulation of protein localization#GO:0032880;cell cycle#GO:0007049;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cellular component organization#GO:0016043;establishment of cell polarity#GO:0030010;regulation of biological process#GO:0050789;cell cycle process#GO:0022402;mitotic cell cycle#GO:0000278;establishment of organelle localization#GO:0051656;cellular component organization or biogenesis#GO:0071840;establishment of mitotic spindle orientation#GO:0000132;establishment of localization#GO:0051234;regulation of localization#GO:0032879;mitotic cell cycle process#GO:1903047;microtubule-based process#GO:0007017;establishment of spindle orientation#GO:0051294;organelle organization#GO:0006996;establishment of mitotic spindle localization#GO:0040001;positive regulation of biological process#GO:0048518;establishment of localization in cell#GO:0051649;establishment of spindle localization#GO:0051293;cellular process#GO:0009987;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007 spindle#GO:0005819;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;microtubule cytoskeleton#GO:0015630;spindle pole#GO:0000922;mitotic spindle pole#GO:0097431;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitotic spindle#GO:0072686;intracellular membraneless organelle#GO:0043232 cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=13427|UniProtKB=Q6XE24 Q6XE24 RBMS3 PTHR24012:SF742 RNA BINDING PROTEIN RNA-BINDING MOTIF, SINGLE-STRANDED-INTERACTING PROTEIN 3 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 protein-containing complex#GO:0032991;ribonucleoprotein complex#GO:1990904 RNA metabolism protein#PC00031 HUMAN|HGNC=17994|UniProtKB=Q96QT4 Q96QT4 TRPM7 PTHR13800:SF8 TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6 TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 7 monoatomic cation channel activity#GO:0005261;catalytic activity, acting on a protein#GO:0140096;passive transmembrane transporter activity#GO:0022803;catalytic activity#GO:0003824;calcium channel activity#GO:0005262;transmembrane transporter activity#GO:0022857;transferase activity, transferring phosphorus-containing groups#GO:0016772;channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;transferase activity#GO:0016740;transporter activity#GO:0005215;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324 calcium ion transport#GO:0006816;monoatomic ion transport#GO:0006811;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;transport#GO:0006810;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=29471|UniProtKB=Q6UX15 Q6UX15 LAYN PTHR14789:SF2 CHONDROLECTIN VARIANT CHODLFDELTAE. LAYILIN organic acid binding#GO:0043177;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;carboxylic acid binding#GO:0031406;anion binding#GO:0043168 HUMAN|HGNC=3682|UniProtKB=P08620 P08620 FGF4 PTHR11486:SF31 FIBROBLAST GROWTH FACTOR FIBROBLAST GROWTH FACTOR 4 molecular function activator activity#GO:0140677;protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;fibroblast growth factor receptor binding#GO:0005104;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;growth factor receptor binding#GO:0070851;growth factor activity#GO:0008083 regulation of locomotion#GO:0040012;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;fibroblast growth factor receptor signaling pathway#GO:0008543;multicellular organismal process#GO:0032501;positive regulation of response to stimulus#GO:0048584;positive regulation of cellular process#GO:0048522;neurogenesis#GO:0022008;positive regulation of MAPK cascade#GO:0043410;cellular developmental process#GO:0048869;regulation of response to stimulus#GO:0048583;regulation of cell migration#GO:0030334;positive regulation of intracellular signal transduction#GO:1902533;developmental process#GO:0032502;response to fibroblast growth factor#GO:0071774;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;response to growth factor#GO:0070848;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;system development#GO:0048731;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of cell motility#GO:2000145;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;nervous system development#GO:0007399;cellular response to fibroblast growth factor stimulus#GO:0044344;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;multicellular organism development#GO:0007275;cell surface receptor signaling pathway#GO:0007166;regulation of MAPK cascade#GO:0043408;signaling#GO:0023052;cell differentiation#GO:0030154;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;regulation of biological process#GO:0050789;positive regulation of cell population proliferation#GO:0008284;response to endogenous stimulus#GO:0009719;cellular response to growth factor stimulus#GO:0071363;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;animal gross anatomical part developmental process#GO:0160108;regulation of intracellular signal transduction#GO:1902531 extracellular region#GO:0005576;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 growth factor#PC00112;intercellular signal molecule#PC00207 FGF signaling pathway#P00021>FGF#P00623 HUMAN|HGNC=3083|UniProtKB=Q96PT3 Q96PT3 DUX5 PTHR46123:SF3 MIX-TYPE HOMEOBOX GENE 1-RELATED DOUBLE HOMEOBOX PROTEIN 1-RELATED sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=9569|UniProtKB=Q9UL46 Q9UL46 PSME2 PTHR10660:SF6 PROTEASOME REGULATOR PA28 PROTEASOME ACTIVATOR COMPLEX SUBUNIT 2 molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;peptidase activator activity#GO:0016504;peptidase regulator activity#GO:0061134;enzyme activator activity#GO:0008047;endopeptidase regulator activity#GO:0061135 biological regulation#GO:0065007;regulation of cell cycle process#GO:0010564;regulation of proteasomal protein catabolic process#GO:0061136;regulation of mitotic cell cycle#GO:0007346;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;regulation of primary metabolic process#GO:0080090;regulation of catabolic process#GO:0009894;regulation of cell cycle G1/S phase transition#GO:1902806;regulation of cell cycle#GO:0051726;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of cell cycle phase transition#GO:1901987;regulation of protein catabolic process#GO:0042176;regulation of mitotic cell cycle phase transition#GO:1901990;regulation of G1/S transition of mitotic cell cycle#GO:2000045 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 Cell cycle#P00013>Proteasome#P00480 HUMAN|HGNC=9479|UniProtKB=P36776 P36776 LONP1 PTHR43718:SF2 LON PROTEASE LON PROTEASE HOMOLOG, MITOCHONDRIAL catalytic activity#GO:0003824;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;ATP-dependent activity#GO:0140657;single-stranded DNA binding#GO:0003697;binding#GO:0005488;nucleic acid binding#GO:0003676;hydrolase activity#GO:0016787;DNA binding#GO:0003677 organelle organization#GO:0006996;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;cellular process#GO:0009987;catabolic process#GO:0009056;protein quality control for misfolded or incompletely synthesized proteins#GO:0006515;mitochondrion organization#GO:0007005;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;protein metabolic process#GO:0019538 intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 protease#PC00190;serine protease#PC00203 HUMAN|HGNC=33105|UniProtKB=Q5VIY5 Q5VIY5 ZNF468 PTHR24377:SF875 IP01015P-RELATED ZINC FINGER PROTEIN 468 double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=10057|UniProtKB=O43567 O43567 RNF13 PTHR22765:SF34 RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING E3 UBIQUITIN-PROTEIN LIGASE RNF13 ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824 modification-dependent protein catabolic process#GO:0019941;regulation of biological process#GO:0050789;primary metabolic process#GO:0044238;negative regulation of biological process#GO:0048519;regulation of cell cycle#GO:0051726;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;cellular process#GO:0009987;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;negative regulation of cell cycle#GO:0045786;macromolecule metabolic process#GO:0043170 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=11291|UniProtKB=P11831 P11831 SRF PTHR48019:SF168 SERUM RESPONSE FACTOR HOMOLOG SERUM RESPONSE FACTOR sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987 regulation of DNA-templated transcription#GO:0006355;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 MADS box transcription factor#PC00250;gene-specific transcriptional regulator#PC00264 PDGF signaling pathway#P00047>SRF#P01165;CCKR signaling map#P06959>SRF#P07181;PDGF signaling pathway#P00047>c-fos#P01145;Interleukin signaling pathway#P00036>SRF#P00987;Ras Pathway#P04393>SRF#P04561;p38 MAPK pathway#P05918>SRF#P06025;Gonadotropin-releasing hormone receptor pathway#P06664>SRF#P06811 HUMAN|HGNC=25054|UniProtKB=Q8NBI3 Q8NBI3 DRAXIN PTHR28610:SF1 DRAXIN DRAXIN cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;animal organ development#GO:0048513;cell projection morphogenesis#GO:0048858;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;head development#GO:0060322;cell morphogenesis involved in neuron differentiation#GO:0048667;negative regulation of signal transduction#GO:0009968;nervous system development#GO:0007399;neuron projection development#GO:0031175;regulation of canonical Wnt signaling pathway#GO:0060828;cellular process#GO:0009987;axonogenesis#GO:0007409;neuron development#GO:0048666;negative regulation of cell communication#GO:0010648;negative regulation of canonical Wnt signaling pathway#GO:0090090;negative regulation of signaling#GO:0023057;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;regulation of signaling#GO:0023051;central nervous system development#GO:0007417;cell differentiation#GO:0030154;cell projection organization#GO:0030030;forebrain development#GO:0030900;cell morphogenesis#GO:0000902;cell development#GO:0048468;regulation of Wnt signaling pathway#GO:0030111;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;cellular developmental process#GO:0048869;neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;central nervous system neuron differentiation#GO:0021953;regulation of response to stimulus#GO:0048583;neuron projection morphogenesis#GO:0048812;brain development#GO:0007420;negative regulation of Wnt signaling pathway#GO:0030178;multicellular organismal process#GO:0032501;negative regulation of response to stimulus#GO:0048585;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;plasma membrane bounded cell projection organization#GO:0120036;axon development#GO:0061564;axon guidance#GO:0007411;anatomical structure development#GO:0048856;system development#GO:0048731;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=29206|UniProtKB=Q9ULN7 Q9ULN7 PNMA8B PTHR23095:SF45 PARANEOPLASTIC ANTIGEN PARANEOPLASTIC ANTIGEN-LIKE PROTEIN 8B transcription cofactor#PC00217 HUMAN|HGNC=16229|UniProtKB=Q9GZP1 Q9GZP1 NRSN2 PTHR14796:SF5 NEURENSIN 1-RELATED NEURENSIN-2 multicellular organism development#GO:0007275;multicellular organismal process#GO:0032501;anatomical structure development#GO:0048856;system development#GO:0048731;nervous system development#GO:0007399;animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502 intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;neuronal cell body#GO:0043025;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;cell body#GO:0044297;intracellular vesicle#GO:0097708;cytoplasm#GO:0005737;somatodendritic compartment#GO:0036477;endomembrane system#GO:0012505;transport vesicle#GO:0030133;neuron projection#GO:0043005 HUMAN|Ensembl=ENSG00000284169.3|UniProtKB=A0A1W2PRS3 A0A1W2PRS3 PTHR11738:SF168 MHC CLASS I NK CELL RECEPTOR IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN-RELATED transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;immune receptor activity#GO:0140375;signaling receptor activity#GO:0038023 cell surface receptor signaling pathway#GO:0007166;regulation of response to stimulus#GO:0048583;regulation of immune response#GO:0050776;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;immune response-regulating signaling pathway#GO:0002764;signal transduction#GO:0007165;regulation of biological process#GO:0050789;immune response-regulating cell surface receptor signaling pathway#GO:0002768;signaling#GO:0023052;biological regulation#GO:0065007;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=1700|UniProtKB=P33681 P33681 CD80 PTHR25466:SF4 T-LYMPHOCYTE ACTIVATION ANTIGEN T-LYMPHOCYTE ACTIVATION ANTIGEN CD80 signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772 immune system process#GO:0002376;immune response#GO:0006955;response to stimulus#GO:0050896 membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 immunoglobulin receptor superfamily#PC00124 T cell activation#P00053>B7#P01337 HUMAN|HGNC=1913|UniProtKB=P18754 P18754 RCC1 PTHR45982:SF9 REGULATOR OF CHROMOSOME CONDENSATION REGULATOR OF CHROMOSOME CONDENSATION guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695 regulation of mitotic spindle organization#GO:0060236;regulation of spindle assembly#GO:0090169;regulation of microtubule-based process#GO:0032886;regulation of cell cycle#GO:0051726;regulation of cellular component biogenesis#GO:0044087;regulation of cytoskeleton organization#GO:0051493;regulation of spindle organization#GO:0090224;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;regulation of mitotic spindle assembly#GO:1901673;biological regulation#GO:0065007;regulation of cell cycle process#GO:0010564;regulation of microtubule cytoskeleton organization#GO:0070507;regulation of organelle assembly#GO:1902115;regulation of mitotic cell cycle#GO:0007346 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=37454|UniProtKB=E9PJ23 E9PJ23 NPIPB6 PTHR15438:SF4 NUCLEAR PORE COMPLEX INTERACTING PROTEIN NUCLEAR PORE COMPLEX-INTERACTING PROTEIN FAMILY MEMBER B15-RELATED HUMAN|HGNC=21157|UniProtKB=Q6ZYL4 Q6ZYL4 GTF2H5 PTHR28580:SF1 GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5 GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5 gene expression#GO:0010467;cellular component assembly#GO:0022607;nucleotide-excision repair#GO:0006289;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;protein-DNA complex assembly#GO:0065004;response to stress#GO:0006950;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component organization or biogenesis#GO:0071840;protein-DNA complex organization#GO:0071824;macromolecule metabolic process#GO:0043170;protein-containing complex organization#GO:0043933;nucleobase-containing compound biosynthetic process#GO:0034654;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA damage response#GO:0006974;transcription by RNA polymerase II#GO:0006366;response to stimulus#GO:0050896;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;cellular response to stimulus#GO:0051716;protein-containing complex assembly#GO:0065003;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;cellular response to stress#GO:0033554 cyclin-dependent protein kinase holoenzyme complex#GO:0000307;protein-containing complex#GO:0032991;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;RNA polymerase II transcription regulator complex#GO:0090575;membrane-enclosed lumen#GO:0031974;protein kinase complex#GO:1902911;intracellular protein-containing complex#GO:0140535;transcription regulator complex#GO:0005667;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234;transcription factor TFIIH core complex#GO:0000439;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554;RNA polymerase II, holoenzyme#GO:0016591;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transcription factor TFIIH holo complex#GO:0005675;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013 general transcription factor#PC00259;RNA metabolism protein#PC00031 HUMAN|HGNC=9889|UniProtKB=Q7Z6E9 Q7Z6E9 RBBP6 PTHR15439:SF0 RETINOBLASTOMA-BINDING PROTEIN 6 E3 UBIQUITIN-PROTEIN LIGASE RBBP6 ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=5344|UniProtKB=P05362 P05362 ICAM1 PTHR13771:SF18 INTERCELLULAR ADHESION MOLECULE INTERCELLULAR ADHESION MOLECULE 1 signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545 cell-cell adhesion#GO:0098609;cellular process#GO:0009987;cell adhesion#GO:0007155;leukocyte cell-cell adhesion#GO:0007159;cell adhesion mediated by integrin#GO:0033627 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;cell periphery#GO:0071944;membrane#GO:0016020 cell adhesion molecule#PC00069 HUMAN|HGNC=30860|UniProtKB=P83369 P83369 LSM11 PTHR21415:SF1 U7 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM11 U7 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM11 snRNA binding#GO:0017069;RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;mRNA 3'-end processing#GO:0031124;RNA 3'-end processing#GO:0031123;macromolecule metabolic process#GO:0043170;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;small nuclear ribonucleoprotein complex#GO:0030532;nucleus#GO:0005634;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031;RNA processing factor#PC00147 HUMAN|HGNC=27405|UniProtKB=Q6UXI9 Q6UXI9 NPNT PTHR24050:SF19 PA14 DOMAIN-CONTAINING PROTEIN NEPHRONECTIN HUMAN|HGNC=15512|UniProtKB=Q8TAA9 Q8TAA9 VANGL1 PTHR20886:SF8 VANG-LIKE PROTEIN VANG-LIKE PROTEIN 1 cell communication#GO:0007154;tissue morphogenesis#GO:0048729;anatomical structure development#GO:0048856;animal gross anatomical part developmental process#GO:0160108;signaling#GO:0023052;Wnt signaling pathway#GO:0016055;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;non-canonical Wnt signaling pathway#GO:0035567;morphogenesis of an epithelium#GO:0002009;developmental process#GO:0032502;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;epithelium development#GO:0060429;tissue development#GO:0009888;signal transduction#GO:0007165;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 HUMAN|HGNC=21862|UniProtKB=Q8WVS4 Q8WVS4 DYNC2I1 PTHR16022:SF0 WD REPEAT DOMAIN 60 CYTOPLASMIC DYNEIN 2 INTERMEDIATE CHAIN 1 protein binding#GO:0005515;binding#GO:0005488 organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031;cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782;cellular component organization#GO:0016043;cilium assembly#GO:0060271;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component assembly#GO:0022607;cell projection organization#GO:0030030;plasma membrane bounded cell projection organization#GO:0120036 spindle pole#GO:0000922;dynein complex#GO:0030286;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cilium#GO:0005929;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;microtubule cytoskeleton#GO:0015630;cytoplasmic dynein complex#GO:0005868;ciliary base#GO:0097546;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;intracellular membraneless organelle#GO:0043232;microtubule organizing center#GO:0005815;centrosome#GO:0005813;spindle#GO:0005819;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228 HUMAN|HGNC=50|UniProtKB=Q9NP78 Q9NP78 ABCB9 PTHR24221:SF242 ATP-BINDING CASSETTE SUB-FAMILY B ABC-TYPE OLIGOPEPTIDE TRANSPORTER ABCB9 primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804;ATPase-coupled transmembrane transporter activity#GO:0042626;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;ATP-dependent activity#GO:0140657 establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;transport#GO:0006810;cellular process#GO:0009987 membrane#GO:0016020;cellular anatomical structure#GO:0110165 ATP-binding cassette (ABC) transporter#PC00003 HUMAN|HGNC=30469|UniProtKB=Q6PJQ5 Q6PJQ5 FOXR2 PTHR46789:SF2 FORKHEAD BOX PROTEIN R1 FORKHEAD BOX PROTEIN R2 binding#GO:0005488;nucleic acid binding#GO:0003676;sequence-specific double-stranded DNA binding#GO:1990837;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;double-stranded DNA binding#GO:0003690 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 winged helix/forkhead transcription factor#PC00246 HUMAN|HGNC=21680|UniProtKB=Q9H0K1 Q9H0K1 SIK2 PTHR24343:SF154 SERINE/THREONINE KINASE SERINE_THREONINE-PROTEIN KINASE SIK2 catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=24600|UniProtKB=Q7Z6G8 Q7Z6G8 ANKS1B PTHR24174:SF3 ANKYRIN REPEAT AND STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 1 ANKYRIN REPEAT AND STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 1B signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515 localization#GO:0051179;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cell surface receptor signaling pathway#GO:0007166;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;ephrin receptor signaling pathway#GO:0048013 intracellular anatomical structure#GO:0005622;cell junction#GO:0030054;presynapse#GO:0098793;cytosol#GO:0005829;cytoplasm#GO:0005737;synapse#GO:0045202;glutamatergic synapse#GO:0098978;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=19429|UniProtKB=Q8IVJ1 Q8IVJ1 SLC41A1 PTHR16228:SF23 DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41 SOLUTE CARRIER FAMILY 41 MEMBER 1 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227;secondary carrier transporter#PC00258 HUMAN|HGNC=18248|UniProtKB=Q6IA86 Q6IA86 ELP2 PTHR44111:SF2 ELONGATOR COMPLEX PROTEIN 2 ELONGATOR COMPLEX PROTEIN 2 protein-containing complex#GO:0032991;elongator holoenzyme complex#GO:0033588;intracellular protein-containing complex#GO:0140535;catalytic complex#GO:1902494 HUMAN|HGNC=7112|UniProtKB=Q9UHC7 Q9UHC7 MKRN1 PTHR11224:SF37 MAKORIN-RELATED E3 UBIQUITIN-PROTEIN LIGASE MAKORIN-1 catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787 macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;cellular process#GO:0009987;protein modification by small protein conjugation#GO:0032446;protein modification process#GO:0036211;primary metabolic process#GO:0044238 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=1537|UniProtKB=O75081 O75081 CBFA2T3 PTHR10379:SF6 MTG8 ETO EIGHT TWENTY ONE PROTEIN TRANSCRIPTIONAL COREPRESSOR CBFA2T3 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714 negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 transcription cofactor#PC00217;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=18358|UniProtKB=Q8NAC3 Q8NAC3 IL17RC PTHR15583:SF12 INTERLEUKIN-17 RECEPTOR INTERLEUKIN-17 RECEPTOR C cytokine receptor activity#GO:0004896;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;immune receptor activity#GO:0140375;signaling receptor activity#GO:0038023 cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;positive regulation of multicellular organismal process#GO:0051240;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;positive regulation of cytokine production#GO:0001819;regulation of cellular process#GO:0050794;signaling#GO:0023052;cytokine-mediated signaling pathway#GO:0019221;cell communication#GO:0007154;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;response to peptide#GO:1901652;regulation of cytokine production#GO:0001817;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;response to cytokine#GO:0034097;response to chemical#GO:0042221;positive regulation of macromolecule metabolic process#GO:0010604;biological regulation#GO:0065007;regulation of multicellular organismal process#GO:0051239;cell surface receptor signaling pathway#GO:0007166;regulation of biosynthetic process#GO:0009889;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=9502|UniProtKB=Q99418 Q99418 CYTH2 PTHR10663:SF343 GUANYL-NUCLEOTIDE EXCHANGE FACTOR CYTOHESIN-2 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 guanyl-nucleotide exchange factor#PC00113 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>GEF#P00875 HUMAN|HGNC=7956|UniProtKB=P25929 P25929 NPY1R PTHR24235:SF24 NEUROPEPTIDE Y RECEPTOR NEUROPEPTIDE Y RECEPTOR TYPE 1 peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;neuropeptide receptor activity#GO:0008188;transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;neuropeptide signaling pathway#GO:0007218;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;cell projection#GO:0042995;membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=7161|UniProtKB=P51511 P51511 MMP15 PTHR10201:SF25 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE-15 metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;extracellular structure organization#GO:0043062;metabolic process#GO:0008152;catabolic process#GO:0009056;cellular process#GO:0009987;cellular component organization#GO:0016043 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 Alzheimer disease-presenilin pathway#P00004>Matrix metalloprotease#P00130;Alzheimer disease-presenilin pathway#P00004>Membrane metalloprotease#P00141 HUMAN|HGNC=29020|UniProtKB=Q5VYK3 Q5VYK3 ECPAS PTHR23346:SF19 TRANSLATIONAL ACTIVATOR GCN1-RELATED PROTEASOME ADAPTER AND SCAFFOLD PROTEIN ECM29 cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;catabolic process#GO:0009056;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;response to endoplasmic reticulum stress#GO:0034976;ERAD pathway#GO:0036503;protein metabolic process#GO:0019538;cellular process#GO:0009987;response to stress#GO:0006950;proteasomal protein catabolic process#GO:0010498;response to chemical#GO:0042221;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=5801|UniProtKB=A0A075B6S6 A0A075B6S6 IGKV2D-30 PTHR23267:SF536 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN KAPPA VARIABLE 2-30-RELATED response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 protein-containing complex#GO:0032991 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=6918|UniProtKB=O95983 O95983 MBD3 PTHR12396:SF12 METHYL-CPG BINDING PROTEIN, MBD METHYL-CPG-BINDING DOMAIN PROTEIN 3 negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;constitutive heterochromatin formation#GO:0140719;negative regulation of gene expression, epigenetic#GO:0045814;DNA methylation-dependent constitutive heterochromatin formation#GO:0006346;cellular component organization or biogenesis#GO:0071840;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;heterochromatin organization#GO:0070828;cellular component assembly#GO:0022607;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of DNA-templated transcription#GO:0006355;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;heterochromatin formation#GO:0031507;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of cellular process#GO:0048523;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090 intracellular organelle lumen#GO:0070013;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ATPase complex#GO:1904949;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;chromosome#GO:0005694;SWI/SNF superfamily-type complex#GO:0070603;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;transcription regulator complex#GO:0005667;histone deacetylase complex#GO:0000118;membrane-enclosed lumen#GO:0031974;chromatin#GO:0000785;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=13053|UniProtKB=P17031 P17031 ZNF26 PTHR24377:SF232 IP01015P-RELATED ZINC FINGER PROTEIN 26 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=1556|UniProtKB=O95503 O95503 CBX6 PTHR46389:SF4 POLYCOMB GROUP PROTEIN PC CHROMOBOX PROTEIN HOMOLOG 6 binding#GO:0005488;chromatin binding#GO:0003682 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253 nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;PRC1 complex#GO:0035102;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;PcG protein complex#GO:0031519;chromatin#GO:0000785;nucleus#GO:0005634;ubiquitin ligase complex#GO:0000151;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;nuclear ubiquitin ligase complex#GO:0000152;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=20266|UniProtKB=Q9Y673 Q9Y673 ALG5 PTHR10859:SF91 GLYCOSYL TRANSFERASE DOLICHYL-PHOSPHATE BETA-GLUCOSYLTRANSFERASE glycosyltransferase activity#GO:0016757;glucosyltransferase activity#GO:0046527;transferase activity#GO:0016740;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020 glycosyltransferase#PC00111 HUMAN|HGNC=11162|UniProtKB=P62306 P62306 SNRPF PTHR11021:SF9 SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F SMALL NUCLEAR RIBONUCLEOPROTEIN F RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 mRNA splicing, via spliceosome#GO:0000398;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170 nuclear protein-containing complex#GO:0140513;catalytic step 2 spliceosome#GO:0071013;Sm-like protein family complex#GO:0120114;U1 snRNP#GO:0005685;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;small nuclear ribonucleoprotein complex#GO:0030532;nucleus#GO:0005634;spliceosomal snRNP complex#GO:0097525;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;spliceosomal complex#GO:0005681 RNA splicing factor#PC00148 HUMAN|HGNC=6354|UniProtKB=Q9UH77 Q9UH77 KLHL3 PTHR24412:SF179 KELCH PROTEIN KELCH-LIKE PROTEIN 3 enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 metal ion transport#GO:0030001;homeostatic process#GO:0042592;catabolic process#GO:0009056;modification-dependent protein catabolic process#GO:0019941;sodium ion transport#GO:0006814;primary metabolic process#GO:0044238;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;proteasomal protein catabolic process#GO:0010498;multicellular organismal process#GO:0032501;renal system process#GO:0003014;cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801;system process#GO:0003008;ubiquitin-dependent protein catabolic process#GO:0006511;renal absorption#GO:0070293;macromolecule metabolic process#GO:0043170;establishment of localization#GO:0051234;chemical homeostasis#GO:0048878;transport#GO:0006810;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161 intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;ubiquitin ligase complex#GO:0000151;Cul3-RING ubiquitin ligase complex#GO:0031463;catalytic complex#GO:1902494;transferase complex#GO:1990234;cytoplasm#GO:0005737;cullin-RING ubiquitin ligase complex#GO:0031461;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytosol#GO:0005829 scaffold/adaptor protein#PC00226 HUMAN|HGNC=801|UniProtKB=P13637 P13637 ATP1A3 PTHR43294:SF15 SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA-3 monoatomic cation transmembrane transporter activity#GO:0008324;potassium ion transmembrane transporter activity#GO:0015079;ATP-dependent activity#GO:0140657;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATPase-coupled transmembrane transporter activity#GO:0042626;primary active transmembrane transporter activity#GO:0015399;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;monoatomic ion transmembrane transporter activity#GO:0015075;P-type ion transporter activity#GO:0015662;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 import across plasma membrane#GO:0098739;export from cell#GO:0140352;homeostatic process#GO:0042592;metal ion transport#GO:0030001;inorganic ion import across plasma membrane#GO:0099587;intracellular monoatomic ion homeostasis#GO:0006873;sodium ion transport#GO:0006814;monoatomic cation transport#GO:0006812;potassium ion homeostasis#GO:0055075;localization#GO:0051179;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;inorganic ion homeostasis#GO:0098771;potassium ion transport#GO:0006813;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;monoatomic ion transmembrane transport#GO:0034220;monoatomic ion homeostasis#GO:0050801;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;potassium ion import across plasma membrane#GO:1990573;import into cell#GO:0098657;establishment of localization#GO:0051234;intracellular chemical homeostasis#GO:0055082;inorganic cation import across plasma membrane#GO:0098659;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 primary active transporter#PC00068;transporter#PC00227 HUMAN|HGNC=16984|UniProtKB=Q59EK9 Q59EK9 RUNDC3A PTHR46251:SF4 RUN DOMAIN-CONTAINING 3 PROTEIN RUNDC3 RUN DOMAIN-CONTAINING PROTEIN 3A HUMAN|HGNC=31884|UniProtKB=P0C7V7 P0C7V7 SEC11B PTHR10806:SF42 SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11 SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11B-RELATED peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;catalytic activity#GO:0003824 gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152 endoplasmic reticulum membrane#GO:0005789;endopeptidase complex#GO:1905369;endoplasmic reticulum#GO:0005783;endoplasmic reticulum protein-containing complex#GO:0140534;organelle membrane#GO:0031090;membrane#GO:0016020;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;peptidase complex#GO:1905368;cytoplasm#GO:0005737;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane protein complex#GO:0098796;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 serine protease#PC00203 HUMAN|HGNC=4399|UniProtKB=P63244 P63244 RACK1 PTHR19868:SF0 RECEPTOR FOR ACTIVATED PROTEIN KINASE C RACK1 SMALL RIBOSOMAL SUBUNIT PROTEIN RACK1 binding#GO:0005488;kinase binding#GO:0019900;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;ribonucleoprotein complex binding#GO:0043021;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;ribosome binding#GO:0043022 primary metabolic process#GO:0044238;negative regulation of protein metabolic process#GO:0051248;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;translation#GO:0006412;protein metabolic process#GO:0019538;negative regulation of macromolecule metabolic process#GO:0010605;macromolecule biosynthetic process#GO:0009059;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of biosynthetic process#GO:0009890;biosynthetic process#GO:0009058;biological regulation#GO:0065007;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;rescue of stalled cytosolic ribosome#GO:0072344;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;negative regulation of metabolic process#GO:0009892;cytoplasmic translation#GO:0002181;protein biosynthetic process#GO:0160307;negative regulation of translation#GO:0017148;organelle disassembly#GO:1903008;cellular component disassembly#GO:0022411;cellular process#GO:0009987;organelle organization#GO:0006996;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of protein metabolic process#GO:0051246;gene expression#GO:0010467;translational elongation#GO:0006414;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840 nucleus#GO:0005634;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=10961|UniProtKB=Q9NPD5 Q9NPD5 SLCO1B3 PTHR11388:SF163 ORGANIC ANION TRANSPORTER SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 1B3 active transmembrane transporter activity#GO:0022804;bile acid transmembrane transporter activity#GO:0015125;carboxylic acid transmembrane transporter activity#GO:0046943;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;secondary active transmembrane transporter activity#GO:0015291 monocarboxylic acid transport#GO:0015718;organic hydroxy compound transport#GO:0015850;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;transport#GO:0006810;carboxylic acid transport#GO:0046942;organic acid transport#GO:0015849;bile acid and bile salt transport#GO:0015721;lipid localization#GO:0010876;lipid transport#GO:0006869;cellular process#GO:0009987;macromolecule localization#GO:0033036 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;cell periphery#GO:0071944;basal plasma membrane#GO:0009925;membrane#GO:0016020;basal part of cell#GO:0045178;basolateral plasma membrane#GO:0016323 transporter#PC00227 HUMAN|HGNC=7218|UniProtKB=P05164 P05164 MPO PTHR11475:SF108 OXIDASE/PEROXIDASE MYELOPEROXIDASE catalytic activity#GO:0003824;antioxidant activity#GO:0016209;peroxidase activity#GO:0004601;oxidoreductase activity, acting on peroxide as acceptor#GO:0016684;oxidoreductase activity#GO:0016491 response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to other organism#GO:0051707;response to stimulus#GO:0050896;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;response to external stimulus#GO:0009605;defense response#GO:0006952;defense response to bacterium#GO:0042742;response to bacterium#GO:0009617 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 metabolite interconversion enzyme#PC00262;peroxidase#PC00180 HUMAN|HGNC=21063|UniProtKB=Q6UVY6 Q6UVY6 MOXD1 PTHR10157:SF28 DOPAMINE BETA HYDROXYLASE RELATED DBH-LIKE MONOOXYGENASE PROTEIN 1 oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;monooxygenase activity#GO:0004497;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705 bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;vesicle membrane#GO:0012506;secretory vesicle#GO:0099503;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;extracellular region#GO:0005576;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;secretory granule membrane#GO:0030667;intracellular vesicle#GO:0097708;vesicle#GO:0031982 hydroxylase#PC00122 HUMAN|HGNC=16632|UniProtKB=Q92665 Q92665 MRPS31 PTHR13231:SF3 MITOCHONDRIAL RIBOSOMAL PROTEIN S31 SMALL RIBOSOMAL SUBUNIT PROTEIN MS31 ribosomal protein#PC00202;translational protein#PC00263 HUMAN|HGNC=12495|UniProtKB=Q15819 Q15819 UBE2V2 PTHR24068:SF177 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2 VARIANT 2 aminoacyltransferase activity#GO:0016755;ubiquitin conjugating enzyme activity#GO:0061631;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein conjugating enzyme activity#GO:0061650;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746 nucleobase-containing compound metabolic process#GO:0006139;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;cellular process#GO:0009987;response to stress#GO:0006950;protein K63-linked ubiquitination#GO:0070534;macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;DNA damage tolerance#GO:0006301;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;response to stimulus#GO:0050896;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;cellular response to stimulus#GO:0051716;DNA replication#GO:0006260;primary metabolic process#GO:0044238;protein modification process#GO:0036211;nucleic acid metabolic process#GO:0090304;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;cellular response to stress#GO:0033554;protein modification by small protein conjugation or removal#GO:0070647 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227 ubiquitin-protein ligase#PC00234 Ubiquitin proteasome pathway#P00060>E2#P01491 HUMAN|HGNC=1237|UniProtKB=Q9NRR5 Q9NRR5 UBQLN4 PTHR10677:SF21 UBIQUILIN UBIQUILIN-4 protein binding#GO:0005515;polyubiquitin modification-dependent protein binding#GO:0031593;modification-dependent protein binding#GO:0140030;binding#GO:0005488 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;catabolic process#GO:0009056;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=28854|UniProtKB=Q5HYK9 Q5HYK9 ZNF667 PTHR24390:SF46 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 667 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218 HUMAN|HGNC=29788|UniProtKB=Q9H2K0 Q9H2K0 MTIF3 PTHR10938:SF9 TRANSLATION INITIATION FACTOR IF-3 TRANSLATION INITIATION FACTOR IF-3, MITOCHONDRIAL translation initiation factor activity#GO:0003743;translation factor activity#GO:0180051 metabolic process#GO:0008152;translation#GO:0006412;translational initiation#GO:0006413;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;mitochondrial gene expression#GO:0140053;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mitochondrial translation#GO:0032543;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058 mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 translation initiation factor#PC00224 HUMAN|HGNC=15404|UniProtKB=Q8NG94 Q8NG94 OR11H1 PTHR24242:SF201 G-PROTEIN COUPLED RECEPTOR OLFACTORY RECEPTOR 11H1-RELATED G-protein coupled receptor#PC00021 HUMAN|HGNC=21075|UniProtKB=Q86VY9 Q86VY9 TMEM200A PTHR31815:SF0 AGAP005329-PA TRANSMEMBRANE PROTEIN 200A HUMAN|HGNC=11658|UniProtKB=Q8WWU5 Q8WWU5 TCP11 PTHR12832:SF14 TESTIS-SPECIFIC PROTEIN PBS13 T-COMPLEX 11 T-COMPLEX PROTEIN 11 HOMOLOG cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of cell development#GO:0060284;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;signaling#GO:0023052;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of reproductive process#GO:2000241;regulation of cell differentiation#GO:0045595;cell communication#GO:0007154 cytoplasm#GO:0005737;sperm flagellum#GO:0036126;endomembrane system#GO:0012505;secretory vesicle#GO:0099503;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cilium#GO:0005929;9+2 motile cilium#GO:0097729;acrosomal vesicle#GO:0001669;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;motile cilium#GO:0031514;organelle#GO:0043226;vesicle#GO:0031982;intracellular vesicle#GO:0097708 microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=3245|UniProtKB=Q9H223 Q9H223 EHD4 PTHR11216:SF57 EH DOMAIN EH DOMAIN-CONTAINING PROTEIN 4 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 endocytic recycling#GO:0032456;cell projection organization#GO:0030030;endocytosis#GO:0006897;protein localization to membrane#GO:0072657;cellular component organization#GO:0016043;cilium assembly#GO:0060271;protein localization to plasma membrane#GO:0072659;cilium organization#GO:0044782;localization#GO:0051179;cellular localization#GO:0051641;localization within membrane#GO:0051668;organelle assembly#GO:0070925;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;cell projection assembly#GO:0030031;cellular process#GO:0009987;organelle organization#GO:0006996;macromolecule localization#GO:0033036;cellular component biogenesis#GO:0044085;endosomal transport#GO:0016197;vesicle-mediated transport to the plasma membrane#GO:0098876;intracellular protein localization#GO:0008104;cellular component organization or biogenesis#GO:0071840;import into cell#GO:0098657;establishment of localization#GO:0051234;transport#GO:0006810;plasma membrane bounded cell projection assembly#GO:0120031;protein localization to cell periphery#GO:1990778;intracellular transport#GO:0046907 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;early endosome#GO:0005769;endocytic vesicle#GO:0030139;endosome#GO:0005768;endosome membrane#GO:0010008;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;plasma membrane#GO:0005886;perinuclear region of cytoplasm#GO:0048471;membrane#GO:0016020;vesicle membrane#GO:0012506;cell periphery#GO:0071944;bounding membrane of organelle#GO:0098588;recycling endosome membrane#GO:0055038;organelle membrane#GO:0031090;recycling endosome#GO:0055037 membrane traffic protein#PC00150 HUMAN|HGNC=3816|UniProtKB=Q92949 Q92949 FOXJ1 PTHR46805:SF1 FORKHEAD BOX PROTEIN J1 FORKHEAD BOX PROTEIN J1 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 winged helix/forkhead transcription factor#PC00246;gene-specific transcriptional regulator#PC00264;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=676|UniProtKB=O43182 O43182 ARHGAP6 PTHR12635:SF6 RHO-GTPASE-ACTIVATING PROTEIN 6 FAMILY MEMBER RHO GTPASE-ACTIVATING PROTEIN 6 enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 cellular component organization or biogenesis#GO:0071840;actin filament organization#GO:0007015;supramolecular fiber organization#GO:0097435;actin filament-based process#GO:0030029;actin cytoskeleton organization#GO:0030036;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987 actin cytoskeleton#GO:0015629;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 GTPase-activating protein#PC00257;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 PDGF signaling pathway#P00047>Rho#P01174 HUMAN|HGNC=53850|UniProtKB=P0DW12 P0DW12 TAF11L7 PTHR13218:SF18 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11-RELATED TATA-BOX-BINDING PROTEIN-ASSOCIATED FACTOR 11-LIKE PROTEIN 10-RELATED protein-containing complex assembly#GO:0065003;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;nucleic acid metabolic process#GO:0090304;DNA-templated transcription#GO:0006351;RNA polymerase II preinitiation complex assembly#GO:0051123;RNA biosynthetic process#GO:0032774;DNA-templated transcription initiation#GO:0006352;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;transcription initiation at RNA polymerase II promoter#GO:0006367;cellular component biogenesis#GO:0044085;protein-DNA complex assembly#GO:0065004;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular component assembly#GO:0022607;transcription by RNA polymerase II#GO:0006366;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;protein-DNA complex organization#GO:0071824;macromolecule metabolic process#GO:0043170 catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;membrane-bounded organelle#GO:0043227;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;RNA polymerase II, holoenzyme#GO:0016591;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;transferase complex#GO:1990234;transcription regulator complex#GO:0005667;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;membrane-enclosed lumen#GO:0031974;transcription factor TFIID complex#GO:0005669;protein-containing complex#GO:0032991 RNA metabolism protein#PC00031;general transcription factor#PC00259 HUMAN|HGNC=23631|UniProtKB=Q6W5P4 Q6W5P4 NPSR1 PTHR24244:SF2 NEUROPEPTIDE S RECEPTOR NEUROPEPTIDE S RECEPTOR G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888;neuropeptide receptor activity#GO:0008188;signaling receptor activity#GO:0038023;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089 regulation of monoatomic cation transmembrane transport#GO:1904062;regulation of release of sequestered calcium ion into cytosol#GO:0051279;regulation of localization#GO:0032879;regulation of transport#GO:0051049;regulation of monoatomic ion transmembrane transport#GO:0034765;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;positive regulation of transport#GO:0051050;positive regulation of biological process#GO:0048518;regulation of transmembrane transport#GO:0034762;regulation of calcium ion transport#GO:0051924;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of metal ion transport#GO:0010959;regulation of monoatomic ion transport#GO:0043269 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=11142|UniProtKB=P57059 P57059 SIK1 PTHR24343:SF204 SERINE/THREONINE KINASE SERINE_THREONINE-PROTEIN KINASE SIK1 protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=10827|UniProtKB=O60239 O60239 SH3BP5 PTHR19423:SF1 SH3 DOMAIN-BINDING PROTEIN 5 SH3 DOMAIN-BINDING PROTEIN 5 enzyme inhibitor activity#GO:0004857;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;protein kinase inhibitor activity#GO:0004860;protein kinase regulator activity#GO:0019887;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;kinase inhibitor activity#GO:0019210;guanyl-nucleotide exchange factor activity#GO:0005085;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;membrane-bounded organelle#GO:0043227;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 scaffold/adaptor protein#PC00226 HUMAN|HGNC=20001|UniProtKB=Q8NBP7 Q8NBP7 PCSK9 PTHR43806:SF60 PEPTIDASE S8 PROPROTEIN CONVERTASE SUBTILISIN_KEXIN TYPE 9 serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;serine-type peptidase activity#GO:0008236;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 serine protease#PC00203 HUMAN|HGNC=11025|UniProtKB=Q07837 Q07837 SLC3A1 PTHR10357:SF240 ALPHA-GLUCOSIDASE FAMILY MEMBER AMINO ACID TRANSPORTER HEAVY CHAIN SLC3A1 primary metabolic process#GO:0044238;cellular process#GO:0009987;catabolic process#GO:0009056;oligosaccharide catabolic process#GO:0009313;carbohydrate metabolic process#GO:0005975;metabolic process#GO:0008152;amino acid transport#GO:0006865;transport#GO:0006810;localization#GO:0051179;carbohydrate catabolic process#GO:0016052;establishment of localization#GO:0051234;oligosaccharide metabolic process#GO:0009311 apical part of cell#GO:0045177;cell projection membrane#GO:0031253;cluster of actin-based cell projections#GO:0098862;apical plasma membrane#GO:0016324;membrane#GO:0016020;cell periphery#GO:0071944;brush border#GO:0005903;plasma membrane region#GO:0098590;brush border membrane#GO:0031526;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane#GO:0005886;plasma membrane bounded cell projection#GO:0120025 metabolite interconversion enzyme#PC00262;amylase#PC00048 HUMAN|HGNC=545|UniProtKB=P20073 P20073 ANXA7 PTHR10502:SF239 ANNEXIN ANNEXIN A7 lipid binding#GO:0008289;phosphatidylserine binding#GO:0001786;ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;phospholipid binding#GO:0005543;binding#GO:0005488 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;vesicle membrane#GO:0012506;membrane#GO:0016020;vesicle#GO:0031982;nucleus#GO:0005634;cell periphery#GO:0071944;organelle#GO:0043226;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 calcium-binding protein#PC00060 HUMAN|HGNC=19877|UniProtKB=Q8IXK2 Q8IXK2 GALNT12 PTHR11675:SF18 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 12 polypeptide N-acetylgalactosaminyltransferase activity#GO:0004653;catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758;UDP-glycosyltransferase activity#GO:0008194;catalytic activity, acting on a protein#GO:0140096;acetylgalactosaminyltransferase activity#GO:0008376;glycosyltransferase activity#GO:0016757 glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;protein O-linked glycosylation#GO:0006493;macromolecule biosynthetic process#GO:0009059;biosynthetic process#GO:0009058;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 glycosyltransferase#PC00111;transferase#PC00220 HUMAN|HGNC=8293|UniProtKB=Q15615 Q15615 OR4D1 PTHR48002:SF15 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 4D1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=7655|UniProtKB=P61601 P61601 NCALD PTHR23055:SF87 CALCIUM BINDING PROTEINS NEUROCALCIN-DELTA tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;calcium ion binding#GO:0005509;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;cation binding#GO:0043169;metal ion binding#GO:0046872;protein binding#GO:0005515 cell communication#GO:0007154;calcium-mediated signaling#GO:0019722;intracellular signal transduction#GO:0035556;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;intracellular signaling cassette#GO:0141124;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 calmodulin-related#PC00061 HUMAN|HGNC=21708|UniProtKB=Q9BSQ5 Q9BSQ5 CCM2 PTHR21642:SF4 CEREBRAL CAVERNOUS MALFORMATIONS PROTEIN 2 HOMOLOG CEREBRAL CAVERNOUS MALFORMATIONS 2 PROTEIN multicellular organismal process#GO:0032501;heart development#GO:0007507;vasculogenesis#GO:0001570;tube development#GO:0035295;cellular process#GO:0009987;cellular developmental process#GO:0048869;animal organ development#GO:0048513;multicellular organism development#GO:0007275;vasculature development#GO:0001944;developmental process#GO:0032502;circulatory system development#GO:0072359;cell differentiation#GO:0030154;blood vessel morphogenesis#GO:0048514;tube morphogenesis#GO:0035239;blood vessel development#GO:0001568;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108 EGF receptor signaling pathway#P00018>MEKK1-5#P00553 HUMAN|HGNC=2554|UniProtKB=Q13619 Q13619 CUL4A PTHR11932:SF68 CULLIN CULLIN-4A enzyme binding#GO:0019899;protein complex scaffold activity#GO:0140378;binding#GO:0005488;ubiquitin-like protein ligase binding#GO:0044389;ubiquitin protein ligase binding#GO:0031625;structural molecule activity#GO:0005198;protein binding#GO:0005515 metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;DNA damage response#GO:0006974;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;cellular component biogenesis#GO:0044085;response to stress#GO:0006950;cellular process#GO:0009987;protein ubiquitination#GO:0016567;proteasomal protein catabolic process#GO:0010498;post-translational protein modification#GO:0043687;protein modification by small protein conjugation or removal#GO:0070647;ribosome biogenesis#GO:0042254;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;modification-dependent macromolecule catabolic process#GO:0043632;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;primary metabolic process#GO:0044238;protein modification process#GO:0036211;modification-dependent protein catabolic process#GO:0019941;protein modification by small protein conjugation#GO:0032446;cellular response to stimulus#GO:0051716;catabolic process#GO:0009056;response to stimulus#GO:0050896;ribonucleoprotein complex biogenesis#GO:0022613 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cullin-RING ubiquitin ligase complex#GO:0031461;nucleus#GO:0005634;ubiquitin ligase complex#GO:0000151;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Cul4-RING E3 ubiquitin ligase complex#GO:0080008;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex#GO:1990234 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=26881|UniProtKB=Q17RS7 Q17RS7 GEN1 PTHR11081:SF70 FLAP ENDONUCLEASE FAMILY MEMBER FLAP ENDONUCLEASE GEN HOMOLOG 1 catalytic activity#GO:0003824;DNA endonuclease activity, producing 5'-phosphomonoesters#GO:0016888;catalytic activity, acting on a nucleic acid#GO:0140640;DNA nuclease activity#GO:0004536;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on DNA#GO:0140097;endonuclease activity#GO:0004519;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA binding#GO:0003677;hydrolase activity#GO:0016787;DNA endonuclease activity#GO:0004520;four-way junction DNA binding#GO:0000400;nuclease activity#GO:0004518 nucleobase-containing compound metabolic process#GO:0006139;replication fork processing#GO:0031297;cellular process#GO:0009987;response to stress#GO:0006950;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;DNA recombination#GO:0006310;DNA damage response#GO:0006974;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;response to stimulus#GO:0050896;double-strand break repair via homologous recombination#GO:0000724;DNA replication#GO:0006260;cellular response to stimulus#GO:0051716;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;DNA-templated DNA replication#GO:0006261;cellular response to stress#GO:0033554;recombinational repair#GO:0000725 DNA metabolism protein#PC00009;exodeoxyribonuclease#PC00098 HUMAN|HGNC=28887|UniProtKB=Q9Y2U8 Q9Y2U8 LEMD3 PTHR13428:SF10 INNER NUCLEAR MEMBRANE PROTEIN MAN1 LEM DOMAIN CONTAINING PROTEIN INNER NUCLEAR MEMBRANE PROTEIN MAN1 chromatin binding#GO:0003682;chromatin DNA binding#GO:0031490;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA binding#GO:0003677 nucleus organization#GO:0006997;cellular component organization or biogenesis#GO:0071840;nuclear envelope organization#GO:0006998;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;nuclear membrane organization#GO:0071763;cellular process#GO:0009987;membrane assembly#GO:0071709;cellular component assembly#GO:0022607;endomembrane system organization#GO:0010256;membrane organization#GO:0061024 nucleus#GO:0005634;organelle envelope#GO:0031967;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=6262|UniProtKB=Q9NPI9 Q9NPI9 KCNJ16 PTHR11767:SF24 INWARD RECTIFIER POTASSIUM CHANNEL INWARD RECTIFIER POTASSIUM CHANNEL 16 voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated monoatomic ion channel activity#GO:0005244;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;transporter activity#GO:0005215;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276;potassium channel activity#GO:0005267;monoatomic cation channel activity#GO:0005261;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094 transport#GO:0006810;inorganic cation import across plasma membrane#GO:0098659;potassium ion import across plasma membrane#GO:1990573;import into cell#GO:0098657;establishment of localization#GO:0051234;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;metal ion transport#GO:0030001;inorganic ion import across plasma membrane#GO:0099587;import across plasma membrane#GO:0098739 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 ion channel#PC00133 HUMAN|HGNC=20041|UniProtKB=Q9H9D4 Q9H9D4 ZNF408 PTHR23226:SF219 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER PROTEIN 408 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=6448|UniProtKB=Q15323 Q15323 KRT31 PTHR23239:SF97 INTERMEDIATE FILAMENT KERATIN, TYPE I CUTICULAR HA1 structural molecule activity#GO:0005198 tissue morphogenesis#GO:0048729;anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;intermediate filament-based process#GO:0045103;animal gross anatomical part developmental process#GO:0160108;intermediate filament organization#GO:0045109;cell differentiation#GO:0030154;intermediate filament cytoskeleton organization#GO:0045104;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;morphogenesis of an epithelium#GO:0002009;developmental process#GO:0032502;epithelium development#GO:0060429;tissue development#GO:0009888;epithelial cell differentiation#GO:0030855;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular process#GO:0009987 supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;organelle#GO:0043226;supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;intermediate filament#GO:0005882;supramolecular fiber#GO:0099512 intermediate filament#PC00129 HUMAN|HGNC=31416|UniProtKB=Q86Z23 Q86Z23 C1QL4 PTHR22923:SF67 CEREBELLIN-RELATED COMPLEMENT C1Q-LIKE PROTEIN 4 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=4803|UniProtKB=P55084 P55084 HADHB PTHR18919:SF147 ACETYL-COA C-ACYLTRANSFERASE TRIFUNCTIONAL ENZYME SUBUNIT BETA, MITOCHONDRIAL acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824;acetyltransferase activity#GO:0016407;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 lipid modification#GO:0030258;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;fatty acid beta-oxidation#GO:0006635;fatty acid oxidation#GO:0019395;monocarboxylic acid catabolic process#GO:0072329;cellular process#GO:0009987;lipid catabolic process#GO:0016042;carboxylic acid catabolic process#GO:0046395;lipid oxidation#GO:0034440;fatty acid catabolic process#GO:0009062;oxoacid metabolic process#GO:0043436;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;small molecule catabolic process#GO:0044282;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;monocarboxylic acid metabolic process#GO:0032787 organelle lumen#GO:0043233;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;oxidoreductase complex#GO:1990204;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;cytoplasm#GO:0005737;transferase complex#GO:1990234 transferase#PC00220;acyltransferase#PC00042 HUMAN|HGNC=18405|UniProtKB=Q8IZT9 Q8IZT9 FAM9C PTHR19368:SF6 XLR/SCP3/FAM9 PROTEIN FAM9C male gamete generation#GO:0048232;cellular process#GO:0009987;cellular developmental process#GO:0048869;meiotic cell cycle#GO:0051321;developmental process#GO:0032502;spermatogenesis#GO:0007283;cell differentiation#GO:0030154;gamete generation#GO:0007276;cell development#GO:0048468;reproductive process#GO:0022414;cellular process involved in reproduction in multicellular organism#GO:0022412;cell cycle#GO:0007049;developmental process involved in reproduction#GO:0003006;germ cell development#GO:0007281;anatomical structure development#GO:0048856;multicellular organismal reproductive process#GO:0048609;spermatid differentiation#GO:0048515;sexual reproduction#GO:0019953;spermatid development#GO:0007286 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;chromosome#GO:0005694;organelle lumen#GO:0043233;condensed nuclear chromosome#GO:0000794;synaptonemal complex#GO:0000795;membraneless organelle#GO:0043228;condensed chromosome#GO:0000793;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;synaptonemal structure#GO:0099086;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974 HUMAN|HGNC=1483|UniProtKB=Q9Y6Q1 Q9Y6Q1 CAPN6 PTHR10183:SF381 CALPAIN CALPAIN-6 cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;cysteine-type endopeptidase activity#GO:0004197;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096 cellular process#GO:0009987;primary metabolic process#GO:0044238;metabolic process#GO:0008152;proteolysis#GO:0006508;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protease#PC00190;cysteine protease#PC00081 Huntington disease#P00029>Calpain#P00788 HUMAN|HGNC=14910|UniProtKB=Q9NYW6 Q9NYW6 TAS2R3 PTHR11394:SF49 TASTE RECEPTOR TYPE 2 TASTE RECEPTOR TYPE 2 MEMBER 3 transmembrane signaling receptor activity#GO:0004888;taste receptor activity#GO:0008527;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;bitter taste receptor activity#GO:0033038 multicellular organismal process#GO:0032501;response to chemical#GO:0042221;response to stimulus#GO:0050896;sensory perception of bitter taste#GO:0050913;detection of chemical stimulus#GO:0009593;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;system process#GO:0003008;detection of chemical stimulus involved in sensory perception of bitter taste#GO:0001580;detection of chemical stimulus involved in sensory perception of taste#GO:0050912;nervous system process#GO:0050877;sensory perception#GO:0007600;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of taste#GO:0050909 cellular anatomical structure#GO:0110165;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=14783|UniProtKB=Q8WZ92 Q8WZ92 OR5P2 PTHR26452:SF90 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5P2 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 nervous system process#GO:0050877;sensory perception#GO:0007600;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=25583|UniProtKB=Q5T2S8 Q5T2S8 ODAD2 PTHR46241:SF1 ARMADILLO REPEAT-CONTAINING PROTEIN 4 ARMC4 OUTER DYNEIN ARM-DOCKING COMPLEX SUBUNIT 2 HUMAN|HGNC=4330|UniProtKB=P35754 P35754 GLRX PTHR46185:SF1 GLUTAREDOXIN-1 GLUTAREDOXIN-1 oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;catalytic activity#GO:0003824;disulfide oxidoreductase activity#GO:0015036;oxidoreductase activity#GO:0016491 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=9285|UniProtKB=O60927 O60927 PPP1R11 PTHR20835:SF4 E3 UBIQUITIN-PROTEIN LIGASE PPP1R11-RELATED E3 UBIQUITIN-PROTEIN LIGASE PPP1R11 protein phosphatase regulator activity#GO:0019888;protein binding#GO:0005515;enzyme regulator activity#GO:0030234;enzyme binding#GO:0019899;binding#GO:0005488;phosphatase binding#GO:0019902;protein phosphatase binding#GO:0019903;molecular function regulator activity#GO:0098772;phosphatase regulator activity#GO:0019208 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=29320|UniProtKB=Q5W0V3 Q5W0V3 FHIP2A PTHR21705:SF10 RAI16 PROTEIN-RELATED FHF COMPLEX SUBUNIT HOOK INTERACTING PROTEIN 2A HUMAN|HGNC=4856|UniProtKB=P51858 P51858 HDGF PTHR12550:SF41 HEPATOMA-DERIVED GROWTH FACTOR-RELATED HEPATOMA-DERIVED GROWTH FACTOR cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;chromatin remodeling#GO:0006338;chromatin organization#GO:0006325 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HUMAN|HGNC=12601|UniProtKB=O75445 O75445 USH2A PTHR10574:SF274 NETRIN/LAMININ-RELATED USHERIN tissue development#GO:0009888;anatomical structure development#GO:0048856;developmental process#GO:0032502 extracellular matrix protein#PC00102 HUMAN|HGNC=11584|UniProtKB=Q9UHD2 Q9UHD2 TBK1 PTHR22969:SF14 IKB KINASE SERINE_THREONINE-PROTEIN KINASE TBK1 protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096 positive regulation of type I interferon production#GO:0032481;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of cytokine production#GO:0001819;regulation of immune system process#GO:0002682;regulation of response to biotic stimulus#GO:0002831;regulation of immune response#GO:0050776;regulation of defense response#GO:0031347;positive regulation of biosynthetic process#GO:0009891;activation of innate immune response#GO:0002218;regulation of cytokine production#GO:0001817;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;positive regulation of innate immune response#GO:0045089;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of response to stress#GO:0080134;positive regulation of defense response#GO:0031349;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;regulation of innate immune response#GO:0045088;regulation of biosynthetic process#GO:0009889;positive regulation of gene expression#GO:0010628;positive regulation of response to biotic stimulus#GO:0002833;regulation of gene expression#GO:0010468;regulation of biological process#GO:0050789;positive regulation of multicellular organismal process#GO:0051240;immune system process#GO:0002376;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of immune system process#GO:0002684;activation of immune response#GO:0002253;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604;regulation of response to external stimulus#GO:0032101;regulation of multicellular organismal process#GO:0051239;positive regulation of response to external stimulus#GO:0032103 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 Toll receptor signaling pathway#P00054>TBK1#P01361 HUMAN|HGNC=8503|UniProtKB=P22059 P22059 OSBP PTHR10972:SF205 OXYSTEROL-BINDING PROTEIN-RELATED OXYSTEROL-BINDING PROTEIN 1 binding#GO:0005488;sterol binding#GO:0032934;lipid binding#GO:0008289;steroid binding#GO:0005496 cell periphery#GO:0071944;cytosol#GO:0005829;membrane#GO:0016020;perinuclear region of cytoplasm#GO:0048471;plasma membrane#GO:0005886;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 transfer/carrier protein#PC00219 HUMAN|HGNC=16892|UniProtKB=P40200 P40200 CD96 PTHR15317:SF1 T-CELL SURFACE PROTEIN TACTILE T-CELL SURFACE PROTEIN TACTILE cellular process#GO:0009987;cell-matrix adhesion#GO:0007160;cell adhesion#GO:0007155;cell-substrate adhesion#GO:0031589 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=19140|UniProtKB=Q5TCY1 Q5TCY1 TTBK1 PTHR11909:SF297 CASEIN KINASE-RELATED TAU-TUBULIN KINASE 1 catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674 cell communication#GO:0007154;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=11137|UniProtKB=Q5SXM2 Q5SXM2 SNAPC4 PTHR46621:SF1 SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4 SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 snRNA transcription#GO:0009301;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;snRNA transcription by RNA polymerase II#GO:0042795;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;transcription by RNA polymerase III#GO:0006383;snRNA metabolic process#GO:0016073;snRNA transcription by RNA polymerase III#GO:0042796;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;transcription by RNA polymerase II#GO:0006366 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667 HUMAN|HGNC=31839|UniProtKB=A8MTQ0 A8MTQ0 NOTO PTHR24339:SF68 HOMEOBOX PROTEIN EMX-RELATED HOMEOBOX PROTEIN NOTOCHORD double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 neuron differentiation#GO:0030182;developmental process#GO:0032502;multicellular organism development#GO:0007275;animal organ development#GO:0048513;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;brain development#GO:0007420;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;nervous system development#GO:0007399;head development#GO:0060322;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;central nervous system development#GO:0007417;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 homeodomain transcription factor#PC00119 HUMAN|HGNC=23017|UniProtKB=O75063 O75063 FAM20B PTHR12450:SF14 DENTIN MATRIX PROTEIN 4 PROTEIN FAM20 GLYCOSAMINOGLYCAN XYLOSYLKINASE phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=16127|UniProtKB=Q5JWF8 Q5JWF8 ACTL10 PTHR11937:SF183 ACTIN ACTIN-LIKE PROTEIN 10 structural molecule activity#GO:0005198;structural constituent of cytoskeleton#GO:0005200 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;actin cytoskeleton#GO:0015629;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 actin and actin related protein#PC00039 HUMAN|HGNC=33704|UniProtKB=Q66K66 Q66K66 TMEM198 PTHR31247:SF7 TRANSMEMBRANE PROTEIN 198 FAMILY MEMBER TRANSMEMBRANE PROTEIN 198 biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of response to stimulus#GO:0048584;positive regulation of Wnt signaling pathway#GO:0030177;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of canonical Wnt signaling pathway#GO:0060828;positive regulation of canonical Wnt signaling pathway#GO:0090263;regulation of response to stimulus#GO:0048583;regulation of Wnt signaling pathway#GO:0030111;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;plasma membrane#GO:0005886;membrane#GO:0016020;intracellular vesicle#GO:0097708;cell periphery#GO:0071944;vesicle#GO:0031982;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HUMAN|HGNC=10588|UniProtKB=Q99250 Q99250 SCN2A PTHR10037:SF278 VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM SODIUM CHANNEL PROTEIN TYPE 2 SUBUNIT ALPHA voltage-gated sodium channel activity#GO:0005248;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261;sodium channel activity#GO:0005272;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324 system process#GO:0003008;transmission of nerve impulse#GO:0019226;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;transport#GO:0006810;biological regulation#GO:0065007;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;multicellular organismal process#GO:0032501;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;monoatomic cation transport#GO:0006812;cell communication#GO:0007154;localization#GO:0051179;transmembrane transport#GO:0055085;sensory perception#GO:0007600;nervous system process#GO:0050877;metal ion transport#GO:0030001;membrane depolarization#GO:0051899;action potential#GO:0001508;sodium ion transport#GO:0006814;sensory perception of pain#GO:0019233 transmembrane transporter complex#GO:1902495;sodium channel complex#GO:0034706;axon#GO:0030424;cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;transporter complex#GO:1990351;cation channel complex#GO:0034703;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005 voltage-gated ion channel#PC00241 HUMAN|HGNC=28994|UniProtKB=Q8NBF6 Q8NBF6 AVL9 PTHR31017:SF1 LATE SECRETORY PATHWAY PROTEIN AVL9-RELATED LATE SECRETORY PATHWAY PROTEIN AVL9 HOMOLOG cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=26230|UniProtKB=Q53R12 Q53R12 TM4SF20 PTHR14198:SF17 TRANSMEMBRANE 4 L6 FAMILY MEMBER 1-RELATED TRANSMEMBRANE 4 L6 FAMILY MEMBER 20 cellular anatomical structure#GO:0110165;membrane#GO:0016020 HUMAN|HGNC=15935|UniProtKB=Q9H4I2 Q9H4I2 ZHX3 PTHR15467:SF6 ZINC-FINGERS AND HOMEOBOXES RELATED ZINC FINGERS AND HOMEOBOXES PROTEIN 3 DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 homeodomain transcription factor#PC00119;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=16696|UniProtKB=Q13573 Q13573 SNW1 PTHR12096:SF0 NUCLEAR PROTEIN SKIP-RELATED SNW DOMAIN-CONTAINING PROTEIN 1 RNA splicing factor#PC00148;RNA processing factor#PC00147 HUMAN|HGNC=2330|UniProtKB=P23786 P23786 CPT2 PTHR22589:SF51 CARNITINE O-ACYLTRANSFERASE CARNITINE O-PALMITOYLTRANSFERASE 2, MITOCHONDRIAL acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;palmitoyltransferase activity#GO:0016409;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740 small molecule catabolic process#GO:0044282;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;fatty acid catabolic process#GO:0009062;lipid oxidation#GO:0034440;oxoacid metabolic process#GO:0043436;monocarboxylic acid catabolic process#GO:0072329;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;lipid catabolic process#GO:0016042;lipid modification#GO:0030258;fatty acid beta-oxidation#GO:0006635;lipid metabolic process#GO:0006629;fatty acid oxidation#GO:0019395;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739 acyltransferase#PC00042;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=25428|UniProtKB=Q5T5P2 Q5T5P2 KIAA1217 PTHR22741:SF11 P140CAP/SNIP-RELATED SICKLE TAIL PROTEIN HOMOLOG cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=12189|UniProtKB=A0A5B0 A0A5B0 TRBV14 PTHR23268:SF38 T-CELL RECEPTOR BETA CHAIN T CELL RECEPTOR BETA VARIABLE 14 cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=6584|UniProtKB=P01229 P01229 LHB PTHR11515:SF11 GLYCOPROTEIN HORMONE BETA CHAIN LUTROPIN SUBUNIT BETA hormone activity#GO:0005179;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018 biological regulation#GO:0065007;gonad development#GO:0008406;multicellular organismal process#GO:0032501;signal transduction#GO:0007165;sex differentiation#GO:0007548;cellular process#GO:0009987;multicellular organism development#GO:0007275;animal organ development#GO:0048513;development of primary sexual characteristics#GO:0045137;developmental process#GO:0032502;signaling#GO:0023052;reproductive structure development#GO:0048608;reproductive process#GO:0022414;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;developmental process involved in reproduction#GO:0003006;female gonad development#GO:0008585;system development#GO:0048731;reproductive system development#GO:0061458;cell communication#GO:0007154;anatomical structure development#GO:0048856;G protein-coupled receptor signaling pathway#GO:0007186;animal gross anatomical part developmental process#GO:0160108 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 peptide hormone#PC00179 Gonadotropin-releasing hormone receptor pathway#P06664>LHbeta#G06688;Gonadotropin-releasing hormone receptor pathway#P06664>3' LHbeta#G06903;Gonadotropin-releasing hormone receptor pathway#P06664>5' LHbeta#G06889;Gonadotropin-releasing hormone receptor pathway#P06664>LHbeta#P06751 HUMAN|HGNC=29668|UniProtKB=Q6FI13 Q6FI13 H2AC18 PTHR23430:SF42 HISTONE H2A HISTONE H2A TYPE 2-A structural molecule activity#GO:0005198 heterochromatin formation#GO:0031507;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;epigenetic regulation of gene expression#GO:0040029;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;chromatin organization#GO:0006325;heterochromatin organization#GO:0070828;cellular component assembly#GO:0022607;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;cellular component organization or biogenesis#GO:0071840;negative regulation of gene expression, epigenetic#GO:0045814;regulation of biosynthetic process#GO:0009889 chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694;nucleosome#GO:0000786;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-DNA complex#GO:0032993;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=20329|UniProtKB=Q6UWJ1 Q6UWJ1 SLC9D1 PTHR16254:SF14 POTASSIUM/PROTON ANTIPORTER-RELATED SOLUTE CARRIER FAMILY 9 MEMBER D1 HUMAN|HGNC=27001|UniProtKB=Q496M5 Q496M5 PLK5 PTHR24345:SF43 SERINE/THREONINE-PROTEIN KINASE PLK INACTIVE SERINE_THREONINE-PROTEIN KINASE PLK5 phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 negative regulation of cell cycle#GO:0045786;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;cell cycle checkpoint signaling#GO:0000075;negative regulation of mitotic cell cycle phase transition#GO:1901991;regulation of cell cycle process#GO:0010564;endomembrane system organization#GO:0010256;cytoskeleton organization#GO:0007010;response to stress#GO:0006950;organelle organization#GO:0006996;cellular process#GO:0009987;signal transduction#GO:0007165;cellular component disassembly#GO:0022411;organelle disassembly#GO:1903008;regulation of mitotic cell cycle phase transition#GO:1901990;negative regulation of mitotic cell cycle#GO:0045930;regulation of G1/S transition of mitotic cell cycle#GO:2000045;cellular response to stress#GO:0033554;mitotic spindle organization#GO:0007052;response to stimulus#GO:0050896;regulation of cell cycle#GO:0051726;signaling#GO:0023052;negative regulation of cell cycle phase transition#GO:1901988;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;cell cycle process#GO:0022402;regulation of biological process#GO:0050789;spindle organization#GO:0007051;mitotic cell cycle process#GO:1903047;negative regulation of cellular process#GO:0048523;negative regulation of cell cycle process#GO:0010948;DNA damage response#GO:0006974;biological regulation#GO:0065007;regulation of mitotic cell cycle#GO:0007346;microtubule cytoskeleton organization#GO:0000226;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of cellular process#GO:0050794;mitotic cell cycle#GO:0000278;regulation of cell cycle G1/S phase transition#GO:1902806;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cell cycle#GO:0007049;regulation of cell cycle phase transition#GO:1901987;mitotic cell cycle checkpoint signaling#GO:0007093;cellular response to stimulus#GO:0051716;Golgi organization#GO:0007030 supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630;condensed chromosome, centromeric region#GO:0000779;nucleus#GO:0005634;membraneless organelle#GO:0043228;spindle#GO:0005819;centrosome#GO:0005813;microtubule organizing center#GO:0005815;chromosome, centromeric region#GO:0000775;cytoskeleton#GO:0005856;condensed chromosome#GO:0000793;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;spindle pole#GO:0000922;chromosome#GO:0005694;kinetochore#GO:0000776;membrane-bounded organelle#GO:0043227;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=12386|UniProtKB=Q9Y5U2 Q9Y5U2 TSSC4 PTHR13445:SF3 TUMOR SUPPRESSING SUBTRANSFERABLE CANDIDATE 4 TSSC4 U5 SMALL NUCLEAR RIBONUCLEOPROTEIN TSSC4 spliceosomal snRNP assembly#GO:0000387;ribonucleoprotein complex biogenesis#GO:0022613;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;protein-containing complex assembly#GO:0065003;mRNA splicing, via spliceosome#GO:0000398;RNA metabolic process#GO:0016070;protein-RNA complex assembly#GO:0022618;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;cellular component assembly#GO:0022607;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;cellular component biogenesis#GO:0044085;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein-RNA complex organization#GO:0071826;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-containing complex organization#GO:0043933;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;spliceosomal snRNP complex#GO:0097525;nuclear protein-containing complex#GO:0140513;Sm-like protein family complex#GO:0120114;U5 snRNP#GO:0005682;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;small nuclear ribonucleoprotein complex#GO:0030532 HUMAN|HGNC=20788|UniProtKB=Q6PJF5 Q6PJF5 RHBDF2 PTHR45965:SF2 INACTIVE RHOMBOID PROTEIN INACTIVE RHOMBOID PROTEIN 2 regulation of protein localization#GO:0032880;regulation of establishment of protein localization#GO:0070201;regulation of secretion by cell#GO:1903530;regulation of secretion#GO:0051046;regulation of signaling#GO:0023051;regulation of cell communication#GO:0010646;regulation of protein transport#GO:0051223;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of ERBB signaling pathway#GO:1901184;regulation of protein secretion#GO:0050708;regulation of transport#GO:0051049;regulation of localization#GO:0032879;regulation of response to stimulus#GO:0048583;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of epidermal growth factor receptor signaling pathway#GO:0042058 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827 serine protease#PC00203 HUMAN|HGNC=567|UniProtKB=Q13367 Q13367 AP3B2 PTHR11134:SF11 ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER AP-3 COMPLEX SUBUNIT BETA-2 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 microtubule-based transport#GO:0099111;post-Golgi vesicle-mediated transport#GO:0006892;cellular localization#GO:0051641;cellular component organization#GO:0016043;establishment of organelle localization#GO:0051656;Golgi vesicle transport#GO:0048193;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;lysosome organization#GO:0007040;organelle organization#GO:0006996;synaptic vesicle transport#GO:0048489;establishment of vesicle localization#GO:0051650;organelle transport along microtubule#GO:0072384;vesicle-mediated transport#GO:0016192;synaptic vesicle localization#GO:0097479;axonal transport#GO:0098930;organelle localization#GO:0051640;vacuole organization#GO:0007033;anterograde axonal transport#GO:0008089;localization#GO:0051179;Golgi to vacuole transport#GO:0006896;microtubule-based movement#GO:0007018;vacuolar transport#GO:0007034;lytic vacuole organization#GO:0080171;transport#GO:0006810;vesicle transport along microtubule#GO:0047496;intracellular transport#GO:0046907;vesicle cytoskeletal trafficking#GO:0099518;anterograde synaptic vesicle transport#GO:0048490;transport along microtubule#GO:0010970;establishment of localization#GO:0051234;vesicle localization#GO:0051648;axo-dendritic transport#GO:0008088;cytoskeleton-dependent intracellular transport#GO:0030705 membrane protein complex#GO:0098796;membrane#GO:0016020;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;coated membrane#GO:0048475;membrane coat#GO:0030117;AP-type membrane coat adaptor complex#GO:0030119;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HUMAN|HGNC=580|UniProtKB=O96018 O96018 APBA3 PTHR12345:SF9 SYNTENIN RELATED AMYLOID-BETA A4 PRECURSOR PROTEIN-BINDING FAMILY A MEMBER 3 peptide binding#GO:0042277;binding#GO:0005488 regulation of biological process#GO:0050789;cellular process#GO:0009987;chemical synaptic transmission#GO:0007268;synaptic signaling#GO:0099536;cell-cell signaling#GO:0007267;signaling#GO:0023052;biological regulation#GO:0065007;anterograde trans-synaptic signaling#GO:0098916;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154 cell junction#GO:0030054;cell periphery#GO:0071944;neuron projection#GO:0043005;membrane#GO:0016020;cytoplasm#GO:0005737;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;dendritic tree#GO:0097447;dendrite#GO:0030425;intracellular anatomical structure#GO:0005622;dendritic spine#GO:0043197;postsynapse#GO:0098794;neuron spine#GO:0044309;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;synapse#GO:0045202;cellular anatomical structure#GO:0110165 membrane traffic protein#PC00150;membrane trafficking regulatory protein#PC00151 Alzheimer disease-amyloid secretase pathway#P00003>Tip60#P00093;Alzheimer disease-amyloid secretase pathway#P00003>X11alpha#P00084 HUMAN|HGNC=4101|UniProtKB=P0DSO3 P0DSO3 GAGE4 PTHR14047:SF30 P ANTIGEN FAMILY MEMBER 5-RELATED G ANTIGEN 1-RELATED HUMAN|HGNC=20619|UniProtKB=Q8TDZ2 Q8TDZ2 MICAL1 PTHR24206:SF59 OS06G0237300 PROTEIN [F-ACTIN]-MONOOXYGENASE MICAL1 binding#GO:0005488;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;actin filament binding#GO:0051015;protein binding#GO:0005515;protein-containing complex binding#GO:0044877 actin filament-based process#GO:0030029;cellular component organization or biogenesis#GO:0071840;actin filament organization#GO:0007015;supramolecular fiber organization#GO:0097435;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;actin filament bundle assembly#GO:0051017;actin filament bundle organization#GO:0061572;cellular process#GO:0009987;cellular component assembly#GO:0022607;actin cytoskeleton organization#GO:0030036;cytoskeleton organization#GO:0007010 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;cell periphery#GO:0071944;actin cytoskeleton#GO:0015629;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=5182|UniProtKB=P35367 P35367 HRH1 PTHR24247:SF223 5-HYDROXYTRYPTAMINE RECEPTOR HISTAMINE H1 RECEPTOR G protein-coupled amine receptor activity#GO:0008227;neurotransmitter receptor activity#GO:0030594;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;postsynaptic neurotransmitter receptor activity#GO:0098960;transmembrane signaling receptor activity#GO:0004888;acetylcholine receptor activity#GO:0015464;molecular transducer activity#GO:0060089 adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway#GO:0007193;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;synaptic signaling#GO:0099536;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;cellular response to nitrogen compound#GO:1901699;acetylcholine receptor signaling pathway#GO:0095500;response to chemical#GO:0042221;response to oxygen-containing compound#GO:1901700;trans-synaptic signaling#GO:0099537;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;response to nitrogen compound#GO:1901698;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;signaling#GO:0023052;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;response to stimulus#GO:0050896 dendrite#GO:0030425;dendritic tree#GO:0097447;cell junction#GO:0030054;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;synapse#GO:0045202;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cell projection#GO:0042995;somatodendritic compartment#GO:0036477;plasma membrane bounded cell projection#GO:0120025 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 Histamine H1 receptor mediated signaling pathway#P04385>H1#P04485;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GsPCR#P00720 HUMAN|HGNC=12243|UniProtKB=P04435 P04435 TRBV7-9 PTHR23268:SF114 T-CELL RECEPTOR BETA CHAIN T CELL RECEPTOR BETA VARIABLE 7-9 signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=1090|UniProtKB=Q03001 Q03001 DST PTHR23169:SF24 ENVOPLAKIN DYSTONIN protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;microtubule binding#GO:0008017;binding#GO:0005488 intermediate filament-based process#GO:0045103;cellular component organization or biogenesis#GO:0071840;wound healing#GO:0042060;response to wounding#GO:0009611;cellular component organization#GO:0016043;response to stress#GO:0006950;organelle organization#GO:0006996;cellular process#GO:0009987;response to stimulus#GO:0050896;intermediate filament cytoskeleton organization#GO:0045104;cytoskeleton organization#GO:0007010 cellular anatomical structure#GO:0110165;organelle#GO:0043226;focal adhesion#GO:0005925;cell-substrate junction#GO:0030055;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;supramolecular fiber#GO:0099512;intracellular organelle#GO:0043229;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;membrane#GO:0016020;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;cell junction#GO:0030054;intermediate filament#GO:0005882;cytoskeleton#GO:0005856 intermediate filament#PC00129;intermediate filament binding protein#PC00130 HUMAN|HGNC=52391|UniProtKB=A0A1B0GTQ4 A0A1B0GTQ4 MYMX PTHR41686:SF1 MYOMIXER PROTEIN MYOMIXER syncytium formation by cell-cell fusion#GO:0000768;cellular developmental process#GO:0048869;anatomical structure development#GO:0048856;animal organ development#GO:0048513;striated muscle cell differentiation#GO:0051146;muscle organ development#GO:0007517;cell-cell fusion#GO:0140253;animal gross anatomical part developmental process#GO:0160108;skeletal muscle organ development#GO:0060538;developmental process#GO:0032502;cell differentiation#GO:0030154;muscle structure development#GO:0061061;myoblast fusion#GO:0007520;muscle cell differentiation#GO:0042692;cellular process#GO:0009987 bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;endoplasmic reticulum#GO:0005783;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;endoplasmic reticulum membrane#GO:0005789;plasma membrane#GO:0005886;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cell periphery#GO:0071944;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=26452|UniProtKB=Q5VSG8 Q5VSG8 MANEAL PTHR13572:SF2 ENDO-ALPHA-1,2-MANNOSIDASE GLYCOPROTEIN ENDO-ALPHA-1,2-MANNOSIDASE-LIKE PROTEIN hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553 HUMAN|HGNC=6252|UniProtKB=Q9ULD8 Q9ULD8 KCNH3 PTHR10217:SF481 VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL VOLTAGE-GATED INWARDLY RECTIFYING POTASSIUM CHANNEL KCNH3 voltage-gated monoatomic ion channel activity#GO:0005244;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261 monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;potassium ion transport#GO:0006813;cellular process#GO:0009987;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;transmembrane transport#GO:0055085;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;localization#GO:0051179;transport#GO:0006810 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133;transporter#PC00227 HUMAN|HGNC=10597|UniProtKB=Q15858 Q15858 SCN9A PTHR10037:SF221 VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM SODIUM CHANNEL PROTEIN TYPE 9 SUBUNIT ALPHA monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic cation channel activity#GO:0005261;voltage-gated sodium channel activity#GO:0005248;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;passive transmembrane transporter activity#GO:0022803;sodium channel activity#GO:0005272;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324 monoatomic cation transport#GO:0006812;cell communication#GO:0007154;localization#GO:0051179;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;sensory perception#GO:0007600;nervous system process#GO:0050877;metal ion transport#GO:0030001;membrane depolarization#GO:0051899;sensory perception of pain#GO:0019233;action potential#GO:0001508;sodium ion transport#GO:0006814;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;transmission of nerve impulse#GO:0019226;system process#GO:0003008;transport#GO:0006810;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987 cation channel complex#GO:0034703;transporter complex#GO:1990351;membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;axon#GO:0030424;transmembrane transporter complex#GO:1902495;sodium channel complex#GO:0034706;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995 voltage-gated ion channel#PC00241 HUMAN|HGNC=4226|UniProtKB=P31150 P31150 GDI1 PTHR11787:SF3 RAB GDP-DISSOCIATION INHIBITOR RAB GDP DISSOCIATION INHIBITOR ALPHA GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HUMAN|HGNC=13345|UniProtKB=Q14693 Q14693 LPIN1 PTHR12181:SF10 LIPIN PHOSPHATIDATE PHOSPHATASE LPIN1 phosphoric ester hydrolase activity#GO:0042578;transcription coactivator activity#GO:0003713;catalytic activity#GO:0003824;transcription coregulator activity#GO:0003712;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;hydrolase activity#GO:0016787;transcription regulator activity#GO:0140110 positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;fatty acid catabolic process#GO:0009062;cellular response to chemical stimulus#GO:0070887;oxoacid metabolic process#GO:0043436;response to oxygen-containing compound#GO:1901700;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;glycerolipid metabolic process#GO:0046486;small molecule metabolic process#GO:0044281;cellular response to endogenous stimulus#GO:0071495;cellular response to hormone stimulus#GO:0032870;small molecule catabolic process#GO:0044282;monocarboxylic acid metabolic process#GO:0032787;response to endogenous stimulus#GO:0009719;carboxylic acid metabolic process#GO:0019752;regulation of biological process#GO:0050789;metabolic process#GO:0008152;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of macromolecule metabolic process#GO:0010604;response to chemical#GO:0042221;response to hormone#GO:0009725;cellular response to oxygen-containing compound#GO:1901701;lipid catabolic process#GO:0016042;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;response to nitrogen compound#GO:1901698;regulation of RNA metabolic process#GO:0051252;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;cellular response to peptide hormone stimulus#GO:0071375;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;response to insulin#GO:0032868;neutral lipid metabolic process#GO:0006638;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;acylglycerol metabolic process#GO:0006639;fatty acid metabolic process#GO:0006631;triglyceride metabolic process#GO:0006641;lipid metabolic process#GO:0006629;cellular response to insulin stimulus#GO:0032869;regulation of nucleobase-containing compound metabolic process#GO:0019219;triglyceride biosynthetic process#GO:0019432;monocarboxylic acid catabolic process#GO:0072329;cellular response to nitrogen compound#GO:1901699;lipid biosynthetic process#GO:0008610;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;biosynthetic process#GO:0009058;response to peptide hormone#GO:0043434;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;carboxylic acid catabolic process#GO:0046395;positive regulation of cellular process#GO:0048522;glycerolipid biosynthetic process#GO:0045017 mitochondrion#GO:0005739;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;outer membrane#GO:0019867;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrial membrane#GO:0031966;nucleus#GO:0005634;mitochondrial envelope#GO:0005740;membrane#GO:0016020;cytoplasm#GO:0005737;organelle outer membrane#GO:0031968;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;mitochondrial outer membrane#GO:0005741 phosphatase#PC00181;hydrolase#PC00121 HUMAN|HGNC=13501|UniProtKB=Q9HBT8 Q9HBT8 ZNF286A PTHR24377:SF217 IP01015P-RELATED ZINC FINGER PROTEIN 286A-RELATED sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=13232|UniProtKB=Q8NHQ8 Q8NHQ8 RASSF8 PTHR15286:SF9 RAS-ASSOCIATING DOMAIN CONTAINING PROTEIN RAS ASSOCIATION DOMAIN-CONTAINING PROTEIN 8 scaffold/adaptor protein#PC00226 HUMAN|HGNC=2032|UniProtKB=O95832 O95832 CLDN1 PTHR12002:SF92 CLAUDIN CLAUDIN-1 virus receptor activity#GO:0001618;protein binding#GO:0005515;binding#GO:0005488 cell-cell junction assembly#GO:0007043;cell-cell junction organization#GO:0045216;cell adhesion#GO:0007155;cellular component organization or biogenesis#GO:0071840;cell-cell adhesion#GO:0098609;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;cell junction assembly#GO:0034329;cellular process#GO:0009987;cell junction organization#GO:0034330;cellular component assembly#GO:0022607 cell periphery#GO:0071944;membrane#GO:0016020;cell-cell junction#GO:0005911;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;bicellular tight junction#GO:0005923;apical junction complex#GO:0043296;anchoring junction#GO:0070161;tight junction#GO:0070160;cell junction#GO:0030054 tight junction#PC00214;cell junction protein#PC00070 HUMAN|HGNC=26429|UniProtKB=Q5H9U9 Q5H9U9 DDX60L PTHR44533:SF1 DEAD/H RNA HELICASE, PUTATIVE-RELATED ATP-DEPENDENT RNA HELICASE DDX60-LIKE-RELATED single-stranded RNA binding#GO:0003727;RNA binding#GO:0003723;double-stranded RNA binding#GO:0003725;binding#GO:0005488;nucleic acid binding#GO:0003676 response to biotic stimulus#GO:0009607;defense response to virus#GO:0051607;response to stress#GO:0006950;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to other organism#GO:0051707;response to virus#GO:0009615;response to external stimulus#GO:0009605;defense response#GO:0006952 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 RNA helicase#PC00032 HUMAN|HGNC=16129|UniProtKB=Q9BYL1 Q9BYL1 SAMD10 PTHR20843:SF1 STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 10 STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 10 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cell surface receptor signaling pathway#GO:0007166 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cytoplasmic side of membrane#GO:0098562;cell periphery#GO:0071944;cytoplasmic side of plasma membrane#GO:0009898;membrane#GO:0016020 HUMAN|HGNC=29554|UniProtKB=Q9C0C9 Q9C0C9 UBE2O PTHR46116:SF51 (E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME (E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;ubiquitin conjugating enzyme activity#GO:0061631;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein conjugating enzyme activity#GO:0061650 cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;endosomal transport#GO:0016197;intracellular transport#GO:0046907;transport#GO:0006810;vesicle-mediated transport#GO:0016192;cytosolic transport#GO:0016482;retrograde transport, endosome to Golgi#GO:0042147;cellular process#GO:0009987;establishment of localization in cell#GO:0051649 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=17881|UniProtKB=Q8IZ57 Q8IZ57 NRSN1 PTHR14796:SF6 NEURENSIN 1-RELATED NEURENSIN-1 animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502;multicellular organismal process#GO:0032501;anatomical structure development#GO:0048856;multicellular organism development#GO:0007275;nervous system development#GO:0007399;system development#GO:0048731 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;vesicle#GO:0031982;cell body#GO:0044297;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;neuronal cell body#GO:0043025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;neuron projection#GO:0043005;cytoplasm#GO:0005737;somatodendritic compartment#GO:0036477;endomembrane system#GO:0012505;transport vesicle#GO:0030133 HUMAN|HGNC=4866|UniProtKB=Q9BQS7 Q9BQS7 HEPH PTHR11709:SF221 MULTI-COPPER OXIDASE HEPHAESTIN catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on metal ions#GO:0016722 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 oxidase#PC00175 HUMAN|HGNC=33717|UniProtKB=Q5VZV1 Q5VZV1 METTL21C PTHR14614:SF13 HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN PROTEIN-LYSINE METHYLTRANSFERASE METTL21C lysine N-methyltransferase activity#GO:0016278;protein-lysine N-methyltransferase activity#GO:0016279;N-methyltransferase activity#GO:0008170;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;catalytic activity, acting on a protein#GO:0140096;protein methyltransferase activity#GO:0008276;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring one-carbon groups#GO:0016741 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protein modifying enzyme#PC00260 HUMAN|HGNC=2481|UniProtKB=P01040 P01040 CSTA PTHR11414:SF20 CYSTATIN FAMILY MEMBER CYSTATIN-A endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772;enzyme inhibitor activity#GO:0004857;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;cysteine-type endopeptidase inhibitor activity#GO:0004869;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414;peptidase regulator activity#GO:0061134 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein-binding activity modulator#PC00095;protease inhibitor#PC00191 HUMAN|HGNC=25226|UniProtKB=Q5TYW1 Q5TYW1 ZNF658 PTHR24376:SF249 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 594-RELATED regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;negative regulation of metabolic process#GO:0009892;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=30551|UniProtKB=P83876 P83876 TXNL4A PTHR12052:SF5 THIOREDOXIN-LIKE PROTEN 4A, 4B THIOREDOXIN-LIKE PROTEIN 4A macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;mRNA splicing, via spliceosome#GO:0000398;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 spliceosomal tri-snRNP complex#GO:0097526;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;spliceosomal snRNP complex#GO:0097525;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;U5 snRNP#GO:0005682;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;small nuclear ribonucleoprotein complex#GO:0030532;protein-containing complex#GO:0032991;U4/U6 x U5 tri-snRNP complex#GO:0046540 oxidoreductase#PC00176 HUMAN|HGNC=26157|UniProtKB=Q9H6R7 Q9H6R7 WDCP PTHR14897:SF5 WD REPEAT AND COILED-COIL-CONTAINING PROTEIN WD REPEAT AND COILED-COIL-CONTAINING PROTEIN enzyme binding#GO:0019899;kinase binding#GO:0019900;binding#GO:0005488;protein binding#GO:0005515 HUMAN|HGNC=24612|UniProtKB=Q53F19 Q53F19 NCBP3 PTHR16291:SF0 NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3 NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3 mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=16918|UniProtKB=O60506 O60506 SYNCRIP PTHR21245:SF11 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN Q RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676 negative regulation of RNA metabolic process#GO:0051253;regulation of mRNA metabolic process#GO:1903311;positive regulation of biological process#GO:0048518;mRNA stabilization#GO:0048255;positive regulation of macromolecule metabolic process#GO:0010604;regulation of biological quality#GO:0065008;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;RNA stabilization#GO:0043489;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of biological process#GO:0050789;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;regulation of mRNA stability#GO:0043488;negative regulation of metabolic process#GO:0009892;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of RNA catabolic process#GO:1902369;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;positive regulation of gene expression#GO:0010628;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA stability#GO:0043487;regulation of RNA metabolic process#GO:0051252;negative regulation of catabolic process#GO:0009895;positive regulation of biosynthetic process#GO:0009891;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255 organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031 HUMAN|HGNC=17158|UniProtKB=Q8IV08 Q8IV08 PLD3 PTHR10185:SF16 PHOSPHOLIPASE D - RELATED 5'-3' EXONUCLEASE PLD3 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 phospholipase#PC00186 HUMAN|HGNC=1726|UniProtKB=P30305 P30305 CDC25B PTHR10828:SF48 M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25 M-PHASE INDUCER PHOSPHATASE 2 catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725;phosphoprotein phosphatase activity#GO:0004721 G2/M transition of mitotic cell cycle#GO:0000086;regulation of cellular process#GO:0050794;cell cycle phase transition#GO:0044770;mitotic cell cycle#GO:0000278;regulation of cell cycle#GO:0051726;regulation of cell cycle phase transition#GO:1901987;cell cycle#GO:0007049;cell cycle process#GO:0022402;regulation of biological process#GO:0050789;regulation of meiotic cell cycle#GO:0051445;positive regulation of cell cycle process#GO:0090068;regulation of G2/M transition of mitotic cell cycle#GO:0010389;regulation of mitotic cell cycle phase transition#GO:1901990;mitotic cell cycle phase transition#GO:0044772;regulation of reproductive process#GO:2000241;positive regulation of cell cycle#GO:0045787;regulation of cell cycle process#GO:0010564;biological regulation#GO:0065007;regulation of cell cycle G2/M phase transition#GO:1902749;regulation of mitotic cell cycle#GO:0007346;cellular process#GO:0009987;cell cycle G2/M phase transition#GO:0044839;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of mitotic cell cycle#GO:0045931;mitotic cell cycle process#GO:1903047 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HUMAN|HGNC=2500|UniProtKB=P29279 P29279 CCN2 PTHR11348:SF7 CONNECTIVE TISSUE GROWTH FACTOR-RELATED CCN FAMILY MEMBER 2 glycosaminoglycan binding#GO:0005539;signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;carbohydrate derivative binding#GO:0097367;cell adhesion molecule binding#GO:0050839;heparin binding#GO:0008201;integrin binding#GO:0005178 positive regulation of developmental process#GO:0051094;regulation of cell differentiation#GO:0045595;positive regulation of cell differentiation#GO:0045597;biological regulation#GO:0065007;signal transduction#GO:0007165;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;cell communication#GO:0007154;cell adhesion#GO:0007155;regulation of developmental process#GO:0050793;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716 cellular anatomical structure#GO:0110165;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576 intercellular signal molecule#PC00207;growth factor#PC00112 HUMAN|HGNC=29182|UniProtKB=Q9UPV0 Q9UPV0 CEP164 PTHR18902:SF27 NUCLEAR MITOTIC APPARATUS PROTEIN 1-RELATED CENTROSOMAL PROTEIN OF 164 KDA plasma membrane bounded cell projection organization#GO:0120036;cell projection organization#GO:0030030;cellular component assembly#GO:0022607;cellular process#GO:0009987;cell projection assembly#GO:0030031;cilium assembly#GO:0060271;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cilium organization#GO:0044782;cellular component organization or biogenesis#GO:0071840;organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031 cytoskeleton#GO:0005856;centrosome#GO:0005813;microtubule organizing center#GO:0005815;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;ciliary transition fiber#GO:0097539;microtubule cytoskeleton#GO:0015630;centriole#GO:0005814;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;cilium#GO:0005929;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226 cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=19715|UniProtKB=Q9HAW4 Q9HAW4 CLSPN PTHR14396:SF10 CLASPIN CLASPIN HUMAN|HGNC=3668|UniProtKB=P61328 P61328 FGF12 PTHR11486:SF17 FIBROBLAST GROWTH FACTOR FIBROBLAST GROWTH FACTOR 12 signaling receptor regulator activity#GO:0030545;ion channel regulator activity#GO:0099106;growth factor activity#GO:0008083;receptor ligand activity#GO:0048018;growth factor receptor binding#GO:0070851;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;fibroblast growth factor receptor binding#GO:0005104;transporter regulator activity#GO:0141108;binding#GO:0005488;signaling receptor binding#GO:0005102;channel regulator activity#GO:0016247;molecular function activator activity#GO:0140677;protein binding#GO:0005515 multicellular organism development#GO:0007275;cell surface receptor signaling pathway#GO:0007166;regulation of MAPK cascade#GO:0043408;nervous system development#GO:0007399;cellular process#GO:0009987;cellular response to fibroblast growth factor stimulus#GO:0044344;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular response to growth factor stimulus#GO:0071363;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;animal gross anatomical part developmental process#GO:0160108;signaling#GO:0023052;cellular response to endogenous stimulus#GO:0071495;cell differentiation#GO:0030154;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;positive regulation of cell population proliferation#GO:0008284;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;positive regulation of MAPK cascade#GO:0043410;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;regulation of cell migration#GO:0030334;developmental process#GO:0032502;response to fibroblast growth factor#GO:0071774;regulation of locomotion#GO:0040012;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;multicellular organismal process#GO:0032501;fibroblast growth factor receptor signaling pathway#GO:0008543;positive regulation of response to stimulus#GO:0048584;positive regulation of cellular process#GO:0048522;system development#GO:0048731;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of cell population proliferation#GO:0042127;regulation of cell motility#GO:2000145;cell communication#GO:0007154;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;response to growth factor#GO:0070848;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;extracellular region#GO:0005576;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 growth factor#PC00112;intercellular signal molecule#PC00207 FGF signaling pathway#P00021>FGF#P00623 HUMAN|HGNC=25971|UniProtKB=Q9H6Y2 Q9H6Y2 WDR55 PTHR44019:SF20 WD REPEAT-CONTAINING PROTEIN 55 WD REPEAT-CONTAINING PROTEIN 55 non-motor microtubule binding protein#PC00166;cytoskeletal protein#PC00085 HUMAN|HGNC=18127|UniProtKB=Q96RT7 Q96RT7 TUBGCP6 PTHR19302:SF70 GAMMA TUBULIN COMPLEX PROTEIN GAMMA-TUBULIN COMPLEX COMPONENT 6 binding#GO:0005488;microtubule binding#GO:0008017;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515 cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;cellular process#GO:0009987;microtubule polymerization or depolymerization#GO:0031109;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;spindle assembly#GO:0051225;protein-containing complex organization#GO:0043933;microtubule polymerization#GO:0046785;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;spindle organization#GO:0007051;chromosome segregation#GO:0007059;meiotic cell cycle#GO:0051321;reproductive process#GO:0022414;mitotic cell cycle#GO:0000278;cytoplasmic microtubule organization#GO:0031122;protein-containing complex assembly#GO:0065003;protein polymerization#GO:0051258;cell cycle process#GO:0022402;cell cycle#GO:0007049;microtubule nucleation#GO:0007020;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;supramolecular fiber organization#GO:0097435;microtubule cytoskeleton organization#GO:0000226;sexual reproduction#GO:0019953;organelle assembly#GO:0070925 cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;microtubule cytoskeleton#GO:0015630;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HUMAN|HGNC=15589|UniProtKB=Q8TDW5 Q8TDW5 SYTL5 PTHR45716:SF6 BITESIZE, ISOFORM I SYNAPTOTAGMIN-LIKE PROTEIN 5 protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 cellular process#GO:0009987;export from cell#GO:0140352;vesicle-mediated transport#GO:0016192;transport#GO:0006810;exocytosis#GO:0006887;secretion by cell#GO:0032940;establishment of localization#GO:0051234;secretion#GO:0046903;localization#GO:0051179 cytoplasm#GO:0005737;plasma membrane#GO:0005886;endomembrane system#GO:0012505;transport vesicle#GO:0030133;cell periphery#GO:0071944;secretory vesicle#GO:0099503;membrane#GO:0016020;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular vesicle#GO:0097708 membrane trafficking regulatory protein#PC00151;membrane traffic protein#PC00150 HUMAN|HGNC=9026|UniProtKB=Q99569 Q99569 PKP4 PTHR10372:SF8 PLAKOPHILLIN-RELATED PLAKOPHILIN-4 binding#GO:0005488;cell adhesion molecule binding#GO:0050839;protein binding#GO:0005515 cellular process#GO:0009987;cell adhesion#GO:0007155;cell-cell adhesion#GO:0098609 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;adherens junction#GO:0005912;membrane-bounded organelle#GO:0043227;cell junction#GO:0030054;nucleus#GO:0005634;cell periphery#GO:0071944;membrane#GO:0016020;cell-cell junction#GO:0005911;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;organelle#GO:0043226 intermediate filament binding protein#PC00130;intermediate filament#PC00129;cytoskeletal protein#PC00085 HUMAN|HGNC=26825|UniProtKB=Q8N8F6 Q8N8F6 YIPF7 PTHR21236:SF5 GOLGI MEMBRANE PROTEIN YIP1 PROTEIN YIPF7 endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;localization#GO:0051179;Golgi organization#GO:0007030;cellular component organization#GO:0016043;vesicle fusion#GO:0006906;transport#GO:0006810;Golgi vesicle transport#GO:0048193;intracellular transport#GO:0046907;vesicle organization#GO:0016050;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;organelle organization#GO:0006996;membrane fusion#GO:0061025;organelle membrane fusion#GO:0090174;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;vesicle-mediated transport#GO:0016192;organelle fusion#GO:0048284 organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;Golgi apparatus subcompartment#GO:0098791 structural protein#PC00211 HUMAN|HGNC=163|UniProtKB=P12814 P12814 ACTN1 PTHR11915:SF434 SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN ALPHA-ACTININ-1 protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;actin filament binding#GO:0051015;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092 muscle cell differentiation#GO:0042692;cellular component organization#GO:0016043;muscle cell development#GO:0055001;cell development#GO:0048468;actin cytoskeleton organization#GO:0030036;muscle structure development#GO:0061061;cell differentiation#GO:0030154;actin filament-based process#GO:0030029;animal gross anatomical part developmental process#GO:0160108;anatomical structure development#GO:0048856;cellular process#GO:0009987;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;developmental process#GO:0032502;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840 cell cortex#GO:0005938;cortical cytoskeleton#GO:0030863;actin cytoskeleton#GO:0015629;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;myofibril#GO:0030016;actin filament bundle#GO:0032432;actomyosin#GO:0042641;cell periphery#GO:0071944;Z disc#GO:0030018;contractile muscle fiber#GO:0043292;membrane#GO:0016020;cytoplasm#GO:0005737;cortical actin cytoskeleton#GO:0030864;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;I band#GO:0031674;cytoskeleton#GO:0005856;stress fiber#GO:0001725;membraneless organelle#GO:0043228;sarcomere#GO:0030017;cell junction#GO:0030054 actin or actin-binding cytoskeletal protein#PC00041 Integrin signalling pathway#P00034>alpha actinin#P00928 HUMAN|HGNC=29105|UniProtKB=O94827 O94827 PLEKHG5 PTHR13217:SF11 PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7 PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 5 guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234 cellular process#GO:0009987;cell migration#GO:0016477;endothelial cell migration#GO:0043542;cell motility#GO:0048870 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cell periphery#GO:0071944;vesicle#GO:0031982;membrane#GO:0016020;intracellular vesicle#GO:0097708;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;endocytic vesicle#GO:0030139;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HUMAN|HGNC=5986|UniProtKB=Q14116 Q14116 IL18 PTHR10078:SF35 INTERLEUKIN-1 FAMILY MEMBER INTERLEUKIN-18 signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;cytokine activity#GO:0005125;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545 cellular response to stimulus#GO:0051716;cellular response to biotic stimulus#GO:0071216;response to external biotic stimulus#GO:0043207;regulation of cellular process#GO:0050794;inflammatory response#GO:0006954;cytokine-mediated signaling pathway#GO:0019221;response to bacterium#GO:0009617;cell communication#GO:0007154;immune response#GO:0006955;response to other organism#GO:0051707;biological regulation#GO:0065007;defense response#GO:0006952;response to external stimulus#GO:0009605;cellular response to molecule of bacterial origin#GO:0071219;regulation of biological process#GO:0050789;response to molecule of bacterial origin#GO:0002237;cellular response to cytokine stimulus#GO:0071345;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;response to oxygen-containing compound#GO:1901700;immune system process#GO:0002376;cellular response to chemical stimulus#GO:0070887;response to peptide#GO:1901652;cellular process#GO:0009987;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;response to stress#GO:0006950;cellular response to lipopolysaccharide#GO:0071222;response to biotic stimulus#GO:0009607;cellular response to lipid#GO:0071396;response to lipid#GO:0033993;response to chemical#GO:0042221;response to cytokine#GO:0034097;cell surface receptor signaling pathway#GO:0007166;response to lipopolysaccharide#GO:0032496 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 cytokine#PC00083;interleukin superfamily#PC00128;intercellular signal molecule#PC00207 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>IL2#P00870;Toll receptor signaling pathway#P00054>Gene trancription#G01550;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>INFgamma#P00878;Interleukin signaling pathway#P00036>Interleukin#P00970 HUMAN|HGNC=26065|UniProtKB=Q96BS2 Q96BS2 TESC PTHR46823:SF2 CALCINEURIN B HOMOLOGOUS PROTEIN 3 CALCINEURIN B HOMOLOGOUS PROTEIN 3 calcium ion binding#GO:0005509;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;cation binding#GO:0043169;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;metal ion binding#GO:0046872;enzyme inhibitor activity#GO:0004857;phosphatase inhibitor activity#GO:0019212;molecular function regulator activity#GO:0098772;phosphatase regulator activity#GO:0019208 regulation of hemopoiesis#GO:1903706;localization#GO:0051179;cellular localization#GO:0051641;regulation of myeloid cell differentiation#GO:0045637;localization within membrane#GO:0051668;regulation of cell adhesion mediated by integrin#GO:0033628;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of developmental process#GO:0050793;protein localization to membrane#GO:0072657;protein localization to plasma membrane#GO:0072659;regulation of biological process#GO:0050789;positive regulation of multicellular organismal process#GO:0051240;regulation of multicellular organismal development#GO:2000026;intracellular protein localization#GO:0008104;protein localization to cell periphery#GO:1990778;positive regulation of developmental process#GO:0051094;positive regulation of cell differentiation#GO:0045597;regulation of cell differentiation#GO:0045595;regulation of cell adhesion#GO:0030155;biological regulation#GO:0065007;regulation of multicellular organismal process#GO:0051239;positive regulation of cell development#GO:0010720;macromolecule localization#GO:0033036;positive regulation of immune system process#GO:0002684;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of myeloid cell differentiation#GO:0045639;cellular process#GO:0009987;regulation of cell development#GO:0060284 plasma membrane#GO:0005886;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;cell periphery#GO:0071944;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=11163|UniProtKB=P62308 P62308 SNRPG PTHR10553:SF26 SMALL NUCLEAR RIBONUCLEOPROTEIN SMALL NUCLEAR RIBONUCLEOPROTEIN G-RELATED nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187 intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;SMN-Sm protein complex#GO:0034719;spliceosomal complex#GO:0005681;U2-type spliceosomal complex#GO:0005684;cellular anatomical structure#GO:0110165;organelle#GO:0043226;U2 snRNP#GO:0005686;P granule#GO:0043186;U5 snRNP#GO:0005682;nuclear protein-containing complex#GO:0140513;small nuclear ribonucleoprotein complex#GO:0030532;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;supramolecular complex#GO:0099080;spliceosomal tri-snRNP complex#GO:0097526;catalytic complex#GO:1902494;precatalytic spliceosome#GO:0071011;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;spliceosomal snRNP complex#GO:0097525;U4 snRNP#GO:0005687;intracellular membrane-bounded organelle#GO:0043231;U2-type prespliceosome#GO:0071004;cytoplasmic ribonucleoprotein granule#GO:0036464;catalytic step 2 spliceosome#GO:0071013;Sm-like protein family complex#GO:0120114;membraneless organelle#GO:0043228;U12-type spliceosomal complex#GO:0005689;nucleus#GO:0005634;U1 snRNP#GO:0005685;ribonucleoprotein granule#GO:0035770 RNA splicing factor#PC00148 HUMAN|HGNC=15620|UniProtKB=Q96LC7 Q96LC7 SIGLEC10 PTHR12035:SF115 SIALIC ACID BINDING IMMUNOGLOBULIN-LIKE LECTIN SIALIC ACID-BINDING IG-LIKE LECTIN 10 carbohydrate derivative binding#GO:0097367;ion binding#GO:0043167;anion binding#GO:0043168;binding#GO:0005488;small molecule binding#GO:0036094;carboxylic acid binding#GO:0031406;organic acid binding#GO:0043177 cell adhesion#GO:0007155;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 cell adhesion molecule#PC00069;immunoglobulin superfamily cell adhesion molecule#PC00125 HUMAN|HGNC=30348|UniProtKB=Q9NW08 Q9NW08 POLR3B PTHR20856:SF8 DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2 DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC2 catalytic activity, acting on RNA#GO:0140098;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;nucleotidyltransferase activity#GO:0016779;transferase activity, transferring phosphorus-containing groups#GO:0016772 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;DNA-templated transcription elongation#GO:0006354;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;transcription by RNA polymerase III#GO:0006383;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;snRNA transcription#GO:0009301;nucleic acid biosynthetic process#GO:0141187;snRNA transcription by RNA polymerase III#GO:0042796;snRNA metabolic process#GO:0016073;RNA metabolic process#GO:0016070 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;RNA polymerase III complex#GO:0005666;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;protein-containing complex#GO:0032991;RNA polymerase complex#GO:0030880;nucleus#GO:0005634 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 HUMAN|HGNC=4191|UniProtKB=P01275 P01275 GCG PTHR11418:SF0 GLUCAGON PRO-GLUCAGON molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;G protein-coupled receptor binding#GO:0001664;protein binding#GO:0005515;molecular function activator activity#GO:0140677;hormone activity#GO:0005179;binding#GO:0005488;signaling receptor binding#GO:0005102 regulation of biological process#GO:0050789;carbohydrate homeostasis#GO:0033500;regulation of hormone levels#GO:0010817;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of protein transport#GO:0051223;positive regulation of secretion#GO:0051047;regulation of signaling#GO:0023051;G protein-coupled receptor signaling pathway#GO:0007186;intracellular glucose homeostasis#GO:0001678;regulation of protein localization#GO:0032880;regulation of secretion by cell#GO:1903530;regulation of biological quality#GO:0065008;positive regulation of metabolic process#GO:0009893;regulation of hormone secretion#GO:0046883;positive regulation of signaling#GO:0023056;positive regulation of secretion by cell#GO:1903532;positive regulation of transport#GO:0051050;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of insulin secretion#GO:0050796;chemical homeostasis#GO:0048878;regulation of transport#GO:0051049;regulation of localization#GO:0032879;glucose homeostasis#GO:0042593;positive regulation of protein secretion#GO:0050714;cellular response to stimulus#GO:0051716;regulation of protein secretion#GO:0050708;regulation of carbohydrate biosynthetic process#GO:0043255;homeostatic process#GO:0042592;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;positive regulation of hormone secretion#GO:0046887;regulation of establishment of protein localization#GO:0070201;regulation of secretion#GO:0051046;positive regulation of biosynthetic process#GO:0009891;cell communication#GO:0007154;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;regulation of carbohydrate metabolic process#GO:0006109;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;regulation of biosynthetic process#GO:0009889 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 CCKR signaling map#P06959>GCG#G07291;CCKR signaling map#P06959>GCG#G06997 HUMAN|HGNC=26498|UniProtKB=Q8N8E2 Q8N8E2 ZNF513 PTHR24403:SF66 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 513 nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=29579|UniProtKB=Q8TC71 Q8TC71 SPATA18 PTHR21771:SF0 MITOCHONDRIA-EATING PROTEIN-RELATED MITOCHONDRIA-EATING PROTEIN molecular condensate scaffold activity#GO:0140693;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 protein catabolic process#GO:0030163;metabolic process#GO:0008152;autophagy of mitochondrion#GO:0000422;macromolecule catabolic process#GO:0009057;process utilizing autophagic mechanism#GO:0061919;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;autophagy#GO:0006914;cellular process#GO:0009987;organelle organization#GO:0006996;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;mitochondrion organization#GO:0007005;catabolic process#GO:0009056 mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;membrane#GO:0016020;membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;organelle outer membrane#GO:0031968;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;mitochondrial outer membrane#GO:0005741;mitochondrion#GO:0005739;organelle envelope#GO:0031967;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;outer membrane#GO:0019867;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=19006|UniProtKB=Q86Z02 Q86Z02 HIPK1 PTHR24058:SF43 DUAL SPECIFICITY PROTEIN KINASE HOMEODOMAIN-INTERACTING PROTEIN KINASE 1 transferase activity#GO:0016740;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 signal transduction#GO:0007165;cellular process#GO:0009987;intrinsic apoptotic signaling pathway in response to DNA damage#GO:0008630;response to stress#GO:0006950;biological regulation#GO:0065007;DNA damage response#GO:0006974;cell surface receptor signaling pathway#GO:0007166;apoptotic signaling pathway#GO:0097190;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;apoptotic process#GO:0006915;cell death#GO:0008219;programmed cell death#GO:0012501;intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator#GO:0042771;signaling#GO:0023052;response to stimulus#GO:0050896;intrinsic apoptotic signaling pathway by p53 class mediator#GO:0072332;regulation of cellular process#GO:0050794;cellular response to stress#GO:0033554;signal transduction by p53 class mediator#GO:0072331;smoothened signaling pathway#GO:0007224;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;intrinsic apoptotic signaling pathway#GO:0097193 nuclear body#GO:0016604;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membraneless organelle#GO:0043228;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;PML body#GO:0016605;organelle lumen#GO:0043233;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 protein modifying enzyme#PC00260 HUMAN|HGNC=7217|UniProtKB=P40238 P40238 MPL PTHR23037:SF31 CYTOKINE RECEPTOR THROMBOPOIETIN RECEPTOR cytokine receptor activity#GO:0004896;transmembrane signaling receptor activity#GO:0004888;immune receptor activity#GO:0140375;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 hemopoiesis#GO:0030097;biological regulation#GO:0065007;response to chemical#GO:0042221;response to cytokine#GO:0034097;signal transduction#GO:0007165;cellular process#GO:0009987;response to chemokine#GO:1990868;anatomical structure formation involved in morphogenesis#GO:0048646;cellular developmental process#GO:0048869;developmental process#GO:0032502;cell surface receptor signaling pathway#GO:0007166;signaling#GO:0023052;cell development#GO:0048468;cellular response to chemokine#GO:1990869;response to stimulus#GO:0050896;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;myeloid cell differentiation#GO:0030099;cell morphogenesis#GO:0000902;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;anatomical structure morphogenesis#GO:0009653;cellular response to stimulus#GO:0051716;response to peptide#GO:1901652;chemokine-mediated signaling pathway#GO:0070098;cell communication#GO:0007154;anatomical structure development#GO:0048856;cytokine-mediated signaling pathway#GO:0019221;G protein-coupled receptor signaling pathway#GO:0007186 side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;plasma membrane#GO:0005886;membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=21898|UniProtKB=Q96SK2 Q96SK2 TMEM209 PTHR21780:SF0 TRANSMEMBRANE PROTEIN 209 TRANSMEMBRANE PROTEIN 209 membrane#GO:0016020;cellular anatomical structure#GO:0110165 HUMAN|HGNC=10489|UniProtKB=P80511 P80511 S100A12 PTHR11639:SF77 S100 CALCIUM-BINDING PROTEIN PROTEIN S100-A12 calcium ion binding#GO:0005509;ion binding#GO:0043167;signaling receptor binding#GO:0005102;small molecule binding#GO:0036094;binding#GO:0005488;cation binding#GO:0043169;protein binding#GO:0005515;metal ion binding#GO:0046872 positive regulation of signaling#GO:0023056;regulation of intracellular signal transduction#GO:1902531;immune system process#GO:0002376;regulation of signaling#GO:0023051;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;regulation of biological process#GO:0050789;positive regulation of canonical NF-kappaB signal transduction#GO:0043123;humoral immune response#GO:0006959;antimicrobial humoral response#GO:0019730;defense response to other organism#GO:0098542;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;defense response to symbiont#GO:0140546;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;positive regulation of cell communication#GO:0010647;cell motility#GO:0048870;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;response to external biotic stimulus#GO:0043207;positive regulation of signal transduction#GO:0009967;defense response#GO:0006952;response to external stimulus#GO:0009605;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;endothelial cell migration#GO:0043542;cell migration#GO:0016477;positive regulation of response to stimulus#GO:0048584;response to other organism#GO:0051707;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of canonical NF-kappaB signal transduction#GO:0043122;immune response#GO:0006955;positive regulation of cellular process#GO:0048522 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 calmodulin-related#PC00061;calcium-binding protein#PC00060 HUMAN|HGNC=30705|UniProtKB=Q8NHS9 Q8NHS9 SPATA22 PTHR35258:SF1 SPERMATOGENESIS-ASSOCIATED PROTEIN 22 SPERMATOGENESIS-ASSOCIATED PROTEIN 22 regulation of biological process#GO:0050789;regulation of meiotic cell cycle#GO:0051445;regulation of cell cycle#GO:0051726;biological regulation#GO:0065007;regulation of reproductive process#GO:2000241;regulation of cellular process#GO:0050794 HUMAN|HGNC=6299|UniProtKB=Q9NR82 Q9NR82 KCNQ5 PTHR47735:SF8 POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4 POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 5 voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;potassium channel activity#GO:0005267;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261 cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;potassium ion transmembrane transport#GO:0071805;potassium ion transport#GO:0006813;transport#GO:0006810;monoatomic ion transport#GO:0006811;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;plasma membrane#GO:0005886;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;cation channel complex#GO:0034703;voltage-gated potassium channel complex#GO:0008076 transporter#PC00227;voltage-gated ion channel#PC00241 HUMAN|HGNC=281|UniProtKB=P08913 P08913 ADRA2A PTHR24248:SF24 ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR ALPHA-2A ADRENERGIC RECEPTOR G protein-coupled amine receptor activity#GO:0008227;hormone binding#GO:0042562;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;cation binding#GO:0043169;molecular transducer activity#GO:0060089 cell communication#GO:0007154;adrenergic receptor signaling pathway#GO:0071875;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway#GO:0007193;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;Alpha adrenergic receptor signaling pathway#P00002>Alpha1A/1B/1C#P00078 HUMAN|HGNC=10448|UniProtKB=Q9P2E9 Q9P2E9 RRBP1 PTHR18939:SF4 RIBOSOME BINDING PROTEIN-1 RIBOSOME-BINDING PROTEIN 1 membrane#GO:0016020;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227 scaffold/adaptor protein#PC00226 HUMAN|HGNC=35445|UniProtKB=A8MY62 A8MY62 LACTBL1 PTHR22935:SF95 PENICILLIN-BINDING PROTEIN BETA-LACTAMASE-LIKE PROTEIN 1 HUMAN|HGNC=29460|UniProtKB=Q5TA81 Q5TA81 LCE2C PTHR48615:SF7 LATE CORNIFIED ENVELOPE PROTEIN 1C LATE CORNIFIED ENVELOPE PROTEIN 2A-RELATED HUMAN|HGNC=57|UniProtKB=O95255 O95255 ABCC6 PTHR24223:SF339 ATP-BINDING CASSETTE SUB-FAMILY C ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 6 ATP-dependent activity#GO:0140657;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;ATPase-coupled transmembrane transporter activity#GO:0042626;active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399;xenobiotic transmembrane transporter activity#GO:0042910 localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ATP-binding cassette (ABC) transporter#PC00003 HUMAN|HGNC=21399|UniProtKB=Q96NZ1 Q96NZ1 FOXN4 PTHR13962:SF17 FORKHEAD BOX PROTEIN N3-LIKE PROTEIN-RELATED FORKHEAD BOX PROTEIN N4 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 winged helix/forkhead transcription factor#PC00246 HUMAN|HGNC=18083|UniProtKB=Q9HBA0 Q9HBA0 TRPV4 PTHR10582:SF4 TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 4 transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;transporter activity#GO:0005215;passive transmembrane transporter activity#GO:0022803;metal ion transmembrane transporter activity#GO:0046873;monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;calcium ion transmembrane transporter activity#GO:0015085 calcium ion transport#GO:0006816;calcium ion transmembrane import into cytosol#GO:0097553;cellular response to abiotic stimulus#GO:0071214;import into cell#GO:0098657;cellular component organization or biogenesis#GO:0071840;cellular response to chemical stress#GO:0062197;cytoskeleton organization#GO:0007010;monoatomic cation transmembrane transport#GO:0098655;response to chemical#GO:0042221;cellular process#GO:0009987;signal transduction#GO:0007165;response to stress#GO:0006950;organelle organization#GO:0006996;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;cellular response to stress#GO:0033554;cellular response to chemical stimulus#GO:0070887;signaling#GO:0023052;import across plasma membrane#GO:0098739;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;response to abiotic stimulus#GO:0009628;cellular component organization#GO:0016043;calcium ion transmembrane transport#GO:0070588;inorganic cation import across plasma membrane#GO:0098659;actin filament organization#GO:0007015;establishment of localization#GO:0051234;transport#GO:0006810;response to osmotic stress#GO:0006970;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;intracellular signal transduction#GO:0035556;supramolecular fiber organization#GO:0097435;cell communication#GO:0007154;localization#GO:0051179;monoatomic cation transport#GO:0006812;actin filament-based process#GO:0030029;cellular response to osmotic stress#GO:0071470;inorganic ion import across plasma membrane#GO:0099587;metal ion transport#GO:0030001;regulation of cellular process#GO:0050794;cellular response to environmental stimulus#GO:0104004;actin cytoskeleton organization#GO:0030036;osmosensory signaling pathway#GO:0007231;cellular response to stimulus#GO:0051716;calcium ion import#GO:0070509 membrane#GO:0016020;cell periphery#GO:0071944;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane#GO:0005886;plasma membrane bounded cell projection#GO:0120025;cilium#GO:0005929;membrane-bounded organelle#GO:0043227 transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=94|UniProtKB=Q9BWD1 Q9BWD1 ACAT2 PTHR18919:SF107 ACETYL-COA C-ACYLTRANSFERASE ACETYL-COA ACETYLTRANSFERASE, CYTOSOLIC acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;catalytic activity#GO:0003824;transferase activity#GO:0016740 acyltransferase#PC00042;transferase#PC00220 HUMAN|HGNC=23493|UniProtKB=Q9HA72 Q9HA72 CALHM2 PTHR32261:SF3 CALCIUM HOMEOSTASIS MODULATOR PROTEIN CALCIUM HOMEOSTASIS MODULATOR PROTEIN 2 monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;passive transmembrane transporter activity#GO:0022803;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 voltage-gated ion channel#PC00241 HUMAN|HGNC=20202|UniProtKB=Q7Z3S7 Q7Z3S7 CACNA2D4 PTHR10166:SF59 VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2_DELTA-4 transporter activity#GO:0005215;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;voltage-gated channel activity#GO:0022832;calcium channel activity#GO:0005262;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261;channel activity#GO:0015267;voltage-gated calcium channel activity#GO:0005245 cation channel complex#GO:0034703;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;membrane#GO:0016020;voltage-gated calcium channel complex#GO:0005891;membrane protein complex#GO:0098796;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;calcium channel complex#GO:0034704;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 voltage-gated ion channel#PC00241;transporter#PC00227 HUMAN|HGNC=32411|UniProtKB=Q4G0T1 Q4G0T1 SCART1 PTHR19331:SF458 SCAVENGER RECEPTOR DOMAIN-CONTAINING SCAVENGER RECEPTOR CYSTEINE-RICH DOMAIN-CONTAINING PROTEIN SCART1 cargo receptor activity#GO:0038024 mononuclear cell differentiation#GO:1903131;leukocyte differentiation#GO:0002521;T cell activation#GO:0042110;leukocyte activation#GO:0045321;cell development#GO:0048468;cell differentiation#GO:0030154;cell activation#GO:0001775;lymphocyte differentiation#GO:0030098;immune system process#GO:0002376;cell fate commitment#GO:0045165;anatomical structure development#GO:0048856;cellular process#GO:0009987;T cell differentiation#GO:0030217;hemopoiesis#GO:0030097;multicellular organismal process#GO:0032501;lymphocyte activation#GO:0046649;developmental process#GO:0032502;cellular developmental process#GO:0048869 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 serine protease#PC00203;protease#PC00190 HUMAN|HGNC=7214|UniProtKB=Q99547 Q99547 MPHOSPH6 PTHR13582:SF0 M-PHASE PHOSPHOPROTEIN 6 M-PHASE PHOSPHOPROTEIN 6 ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;ribonucleoprotein complex biogenesis#GO:0022613;maturation of 5.8S rRNA#GO:0000460;RNA biosynthetic process#GO:0032774;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396 organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=18052|UniProtKB=Q9H0F5 Q9H0F5 RNF38 PTHR46171:SF1 GH10160P E3 UBIQUITIN-PROTEIN LIGASE RNF38 catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630 macromolecule metabolic process#GO:0043170;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;cellular process#GO:0009987;protein modification process#GO:0036211;primary metabolic process#GO:0044238 HUMAN|HGNC=27274|UniProtKB=Q5T292 Q5T292 TMEM273 PTHR37857:SF1 TRANSMEMBRANE PROTEIN 273 TRANSMEMBRANE PROTEIN 273 HUMAN|HGNC=30203|UniProtKB=Q9Y284 Q9Y284 WDR83OS PTHR13193:SF0 CGI-140 PAT COMPLEX SUBUNIT ASTERIX cellular localization#GO:0051641;localization#GO:0051179;localization within membrane#GO:0051668;protein localization to organelle#GO:0033365;protein insertion into ER membrane#GO:0045048;endoplasmic reticulum organization#GO:0007029;cellular component organization#GO:0016043;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;membrane organization#GO:0061024;endomembrane system organization#GO:0010256;protein insertion into membrane#GO:0051205;cellular process#GO:0009987;establishment of protein localization#GO:0045184;organelle organization#GO:0006996;macromolecule localization#GO:0033036;establishment of protein localization to membrane#GO:0090150 endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane#GO:0016020;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=16060|UniProtKB=Q8WWH5 Q8WWH5 TRUB1 PTHR13767:SF2 TRNA-PSEUDOURIDINE SYNTHASE PSEUDOURIDYLATE SYNTHASE TRUB1 intramolecular transferase activity#GO:0016866;catalytic activity#GO:0003824;isomerase activity#GO:0016853 mRNA modification#GO:0016556;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;pseudouridine synthesis#GO:0001522;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;tRNA modification#GO:0006400;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 metabolite interconversion enzyme#PC00262;isomerase#PC00135 HUMAN|HGNC=6323|UniProtKB=Q12840 Q12840 KIF5A PTHR24115:SF937 KINESIN-RELATED KINESIN HEAVY CHAIN ISOFORM 5A binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP-dependent activity#GO:0140657;plus-end-directed microtubule motor activity#GO:0008574;protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;hydrolase activity, acting on acid anhydrides#GO:0016817;cytoskeletal motor activity#GO:0003774;microtubule binding#GO:0008017;polypeptide conformation or assembly isomerase activity#GO:0120544;hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887;microtubule motor activity#GO:0003777;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;tubulin binding#GO:0015631;macromolecular conformation isomerase activity#GO:0120543;isomerase activity#GO:0016853;ribonucleoside triphosphate phosphatase activity#GO:0017111 anterograde axonal transport#GO:0008089;cellular localization#GO:0051641;localization#GO:0051179;microtubule-based transport#GO:0099111;organelle localization#GO:0051640;axonal transport#GO:0098930;microtubule-based movement#GO:0007018;establishment of organelle localization#GO:0051656;mitochondrion localization#GO:0051646;microtubule-based process#GO:0007017;vesicle cytoskeletal trafficking#GO:0099518;transport along microtubule#GO:0010970;establishment of localization#GO:0051234;transport#GO:0006810;intracellular transport#GO:0046907;vesicle transport along microtubule#GO:0047496;organelle transport along microtubule#GO:0072384;establishment of vesicle localization#GO:0051650;synaptic vesicle localization#GO:0097479;cytoskeleton-dependent intracellular transport#GO:0030705;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle localization#GO:0051648;synaptic vesicle transport#GO:0048489;axo-dendritic transport#GO:0008088 supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;microtubule associated complex#GO:0005875;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=53852|UniProtKB=A0A1W2PR64 A0A1W2PR64 TAF11L9 PTHR13218:SF18 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11-RELATED TATA-BOX-BINDING PROTEIN-ASSOCIATED FACTOR 11-LIKE PROTEIN 10-RELATED protein-DNA complex organization#GO:0071824;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-containing complex organization#GO:0043933;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;transcription by RNA polymerase II#GO:0006366;gene expression#GO:0010467;cellular component assembly#GO:0022607;biosynthetic process#GO:0009058;protein-DNA complex assembly#GO:0065004;nucleobase-containing compound metabolic process#GO:0006139;cellular component biogenesis#GO:0044085;transcription initiation at RNA polymerase II promoter#GO:0006367;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;DNA-templated transcription initiation#GO:0006352;RNA polymerase II preinitiation complex assembly#GO:0051123;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003 protein-containing complex#GO:0032991;transcription factor TFIID complex#GO:0005669;RNA polymerase II transcription regulator complex#GO:0090575;membrane-enclosed lumen#GO:0031974;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;transcription regulator complex#GO:0005667;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;RNA polymerase II, holoenzyme#GO:0016591;membrane-bounded organelle#GO:0043227;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle#GO:0043229;catalytic complex#GO:1902494 general transcription factor#PC00259;RNA metabolism protein#PC00031 HUMAN|HGNC=23169|UniProtKB=Q9Y224 Q9Y224 RTRAF PTHR15924:SF11 CLE TRNA-SPLICING LIGASE COMPLEX SUBUNIT RTRAF RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;tRNA splicing, via endonucleolytic cleavage and ligation#GO:0006388;RNA biosynthetic process#GO:0032774 catalytic complex#GO:1902494;protein-containing complex#GO:0032991;intracellular protein-containing complex#GO:0140535 HUMAN|HGNC=11039|UniProtKB=Q9NY91 Q9NY91 SLC5A4 PTHR11819:SF112 SOLUTE CARRIER FAMILY 5 GLUCOSE SENSOR PROTEIN SLC5A4-RELATED transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 carbohydrate transmembrane transport#GO:0034219;multicellular organismal process#GO:0032501;import across plasma membrane#GO:0098739;cellular process#GO:0009987;renal system process#GO:0003014;D-glucose transmembrane transport#GO:1904659;import into cell#GO:0098657;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;renal absorption#GO:0070293;system process#GO:0003008;transport#GO:0006810;carbohydrate transport#GO:0008643 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;transporter#PC00227 HUMAN|HGNC=28032|UniProtKB=Q5J8M3 Q5J8M3 EMC4 PTHR19315:SF9 ER MEMBRANE PROTEIN COMPLEX SUBUNIT 4 ER MEMBRANE PROTEIN COMPLEX SUBUNIT 4 molecular carrier activity#GO:0140104;membrane insertase activity#GO:0032977;protein carrier activity#GO:0140597 intracellular protein localization#GO:0008104;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;establishment of protein localization#GO:0045184;cellular process#GO:0009987;macromolecule localization#GO:0033036;establishment of protein localization to membrane#GO:0090150;organelle organization#GO:0006996;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;tail-anchored membrane protein insertion into ER membrane#GO:0071816;protein insertion into membrane#GO:0051205;localization within membrane#GO:0051668;localization#GO:0051179;cellular localization#GO:0051641;endoplasmic reticulum organization#GO:0007029;protein insertion into ER membrane#GO:0045048;cellular component organization#GO:0016043;protein localization to organelle#GO:0033365 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;EMC complex#GO:0072546;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane protein complex#GO:0098796;organelle membrane#GO:0031090;endoplasmic reticulum protein-containing complex#GO:0140534;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;membrane#GO:0016020 HUMAN|HGNC=10761|UniProtKB=Q15047 Q15047 SETDB1 PTHR46024:SF2 HISTONE-LYSINE N-METHYLTRANSFERASE EGGLESS HISTONE-LYSINE N-METHYLTRANSFERASE SETDB1 histone modifying activity#GO:0140993;histone H3 methyltransferase activity#GO:0140938;lysine N-methyltransferase activity#GO:0016278;N-methyltransferase activity#GO:0008170;protein-lysine N-methyltransferase activity#GO:0016279;histone methyltransferase activity#GO:0042054;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;catalytic activity, acting on a protein#GO:0140096;protein methyltransferase activity#GO:0008276;transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;catalytic activity#GO:0003824 negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;chromatin organization#GO:0006325;heterochromatin organization#GO:0070828;negative regulation of cellular process#GO:0048523;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 histone modifying enzyme#PC00261 HUMAN|HGNC=55526|UniProtKB=Q96E66 Q96E66 LRRC51 PTHR46545:SF1 LEUCINE-RICH REPEAT-CONTAINING PROTEIN 51 LEUCINE-RICH REPEAT-CONTAINING PROTEIN 51 cytoskeleton#GO:0005856;cilium#GO:0005929;intracellular organelle#GO:0043229;axoneme#GO:0005930;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;ciliary plasm#GO:0097014;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025 HUMAN|HGNC=9366|UniProtKB=P02810 P02810 PRH1 PTHR23203:SF19 PROLINE-RICH PROTEIN SALIVARY ACIDIC PROLINE-RICH PHOSPHOPROTEIN 1_2 antimicrobial response protein#PC00051 HUMAN|HGNC=7215|UniProtKB=Q99550 Q99550 MPHOSPH9 PTHR14926:SF1 M-PHASE PHOSPHOPROTEIN 9 M-PHASE PHOSPHOPROTEIN 9 microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;centriole#GO:0005814;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 HUMAN|HGNC=14220|UniProtKB=Q96P63 Q96P63 SERPINB12 PTHR11461:SF125 SERINE PROTEASE INHIBITOR, SERPIN SERPIN B12 peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;peptidase regulator activity#GO:0061134;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;serine-type endopeptidase inhibitor activity#GO:0004867;enzyme inhibitor activity#GO:0004857;endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease inhibitor#PC00191 HUMAN|HGNC=28826|UniProtKB=Q6UXN9 Q6UXN9 WDR82 PTHR19861:SF0 WD40 REPEAT PROTEIN SWD2 WD REPEAT-CONTAINING PROTEIN 82 binding#GO:0005488;chromatin binding#GO:0003682 protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;Set1C/COMPASS complex#GO:0048188;nuclear protein-containing complex#GO:0140513;histone methyltransferase complex#GO:0035097;transferase complex#GO:1990234;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;methyltransferase complex#GO:0034708;nucleoplasm#GO:0005654;organelle lumen#GO:0043233;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013 metabolite interconversion enzyme#PC00262;transferase#PC00220;methyltransferase#PC00155 HUMAN|HGNC=24219|UniProtKB=O15446 O15446 POLR1G PTHR15484:SF8 DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34 DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34 intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;membrane-enclosed lumen#GO:0031974;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;organelle lumen#GO:0043233;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;RNA polymerase I complex#GO:0005736;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;transferase complex, transferring phosphorus-containing groups#GO:0061695 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 HUMAN|HGNC=29953|UniProtKB=Q8WWZ8 Q8WWZ8 OIT3 PTHR14002:SF18 ENDOGLIN/TGF-BETA RECEPTOR TYPE III ONCOPROTEIN-INDUCED TRANSCRIPT 3 PROTEIN cellular anatomical structure#GO:0110165;cell surface#GO:0009986;extracellular region#GO:0005576 transmembrane signal receptor#PC00197 HUMAN|HGNC=4720|UniProtKB=P22492 P22492 H1-6 PTHR11467:SF18 HISTONE H1 HISTONE H1T chromatin DNA binding#GO:0031490;chromatin binding#GO:0003682;nucleic acid binding#GO:0003676;binding#GO:0005488;protein-containing complex binding#GO:0044877;nucleosome binding#GO:0031491;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677 multicellular organismal reproductive process#GO:0048609;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;chromosome condensation#GO:0030261;regulation of DNA recombination#GO:0000018;sexual reproduction#GO:0019953;regulation of cellular process#GO:0050794;gamete generation#GO:0007276;regulation of macromolecule metabolic process#GO:0060255;reproductive process#GO:0022414;negative regulation of metabolic process#GO:0009892;developmental process involved in reproduction#GO:0003006;cellular component organization#GO:0016043;negative regulation of DNA recombination#GO:0045910;negative regulation of biological process#GO:0048519;regulation of DNA metabolic process#GO:0051052;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;chromosome organization#GO:0051276;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;spermatogenesis#GO:0007283;male gamete generation#GO:0048232;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of DNA metabolic process#GO:0051053;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;organelle organization#GO:0006996;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=37242|UniProtKB=Q86WV5 Q86WV5 TEN1 PTHR33905:SF1 CST COMPLEX SUBUNIT TEN1 CST COMPLEX SUBUNIT TEN1 enzyme inhibitor activity#GO:0004857;sequence-specific DNA binding#GO:0043565;molecular function regulator activity#GO:0098772;telomeric repeat DNA binding#GO:0042162;binding#GO:0005488;nucleic acid binding#GO:0003676;enzyme regulator activity#GO:0030234;DNA binding#GO:0003677;molecular function inhibitor activity#GO:0140678 negative regulation of organelle organization#GO:0010639;negative regulation of cellular component organization#GO:0051129;negative regulation of biological process#GO:0048519;regulation of organelle organization#GO:0033043;regulation of DNA metabolic process#GO:0051052;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular component organization#GO:0051128;negative regulation of metabolic process#GO:0009892;negative regulation of chromosome organization#GO:2001251;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of macromolecule biosynthetic process#GO:0010556;regulation of telomere maintenance via telomere lengthening#GO:1904356;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of DNA metabolic process#GO:0051053;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of chromosome organization#GO:0033044;negative regulation of cellular process#GO:0048523;regulation of biosynthetic process#GO:0009889;regulation of telomere maintenance#GO:0032204 membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;protein-containing complex#GO:0032991;chromosome, telomeric region#GO:0000781;intracellular membraneless organelle#GO:0043232;intracellular organelle#GO:0043229;nuclear telomere cap complex#GO:0000783;intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687;chromosome, telomeric repeat region#GO:0140445;membrane-bounded organelle#GO:0043227;chromosome#GO:0005694;cellular anatomical structure#GO:0110165;organelle#GO:0043226;protein-DNA complex#GO:0032993;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=9611|UniProtKB=Q05397 Q05397 PTK2 PTHR24418:SF78 TYROSINE-PROTEIN KINASE FOCAL ADHESION KINASE 1 catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein tyrosine kinase activity#GO:0004713;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;non-membrane spanning protein tyrosine kinase activity#GO:0004715 cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of cell motility#GO:2000145;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;positive regulation of cell motility#GO:2000147;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cell surface receptor signaling pathway#GO:0007166;regulation of cell migration#GO:0030334;positive regulation of locomotion#GO:0040017;positive regulation of cell migration#GO:0030335;ERBB signaling pathway#GO:0038127;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of cellular process#GO:0048522;regulation of locomotion#GO:0040012;biological regulation#GO:0065007;regulation of cell adhesion#GO:0030155;epidermal growth factor receptor signaling pathway#GO:0007173 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;focal adhesion#GO:0005925;cell-substrate junction#GO:0030055;cellular anatomical structure#GO:0110165;anchoring junction#GO:0070161;cell junction#GO:0030054 non-receptor tyrosine protein kinase#PC00168 VEGF signaling pathway#P00056>FAK#P01420;Integrin signalling pathway#P00034>FAK#P00932;Gonadotropin-releasing hormone receptor pathway#P06664>FAK#P06707;Angiogenesis#P00005>FAK#P00209;CCKR signaling map#P06959>FAK1#P07129 HUMAN|HGNC=4043|UniProtKB=Q13467 Q13467 FZD5 PTHR11309:SF136 FRIZZLED FRIZZLED-5 signaling receptor activity#GO:0038023;protein binding#GO:0005515;molecular transducer activity#GO:0060089;Wnt-protein binding#GO:0017147;transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488 cell surface receptor signaling pathway#GO:0007166;canonical Wnt signaling pathway#GO:0060070;cell communication#GO:0007154;non-canonical Wnt signaling pathway#GO:0035567;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;Wnt signaling pathway#GO:0016055;biological regulation#GO:0065007;signaling#GO:0023052 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 Cadherin signaling pathway#P00012>Frizzled#P00475;Angiogenesis#P00005>Fzd#P00189;Alzheimer disease-presenilin pathway#P00004>Frizzled#P00119;Wnt signaling pathway#P00057>Frizzled#P01428 HUMAN|HGNC=541|UniProtKB=P12429 P12429 ANXA3 PTHR10502:SF25 ANNEXIN ANNEXIN A3 small molecule binding#GO:0036094;anion binding#GO:0043168;binding#GO:0005488;phospholipid binding#GO:0005543;ion binding#GO:0043167;lipid binding#GO:0008289;phosphatidylserine binding#GO:0001786 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;plasma membrane#GO:0005886;membrane#GO:0016020;vesicle membrane#GO:0012506;cell periphery#GO:0071944;nucleus#GO:0005634;vesicle#GO:0031982;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 calcium-binding protein#PC00060 HUMAN|HGNC=21607|UniProtKB=Q9NVV5 Q9NVV5 AIG1 PTHR10989:SF11 ANDROGEN-INDUCED PROTEIN 1-RELATED ANDROGEN-INDUCED GENE 1 PROTEIN catalytic activity#GO:0003824;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787 monocarboxylic acid catabolic process#GO:0072329;carboxylic acid catabolic process#GO:0046395;lipid catabolic process#GO:0016042;cellular process#GO:0009987;long-chain fatty acid metabolic process#GO:0001676;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;small molecule catabolic process#GO:0044282;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;fatty acid catabolic process#GO:0009062;oxoacid metabolic process#GO:0043436 HUMAN|HGNC=16135|UniProtKB=Q8N6M3 Q8N6M3 FITM2 PTHR23129:SF1 ACYL-COENZYME A DIPHOSPHATASE FITM2 ACYL-COENZYME A DIPHOSPHATASE FITM2 hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818 cellular component assembly#GO:0022607;homeostatic process#GO:0042592;membraneless organelle assembly#GO:0140694;lipid homeostasis#GO:0055088;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;lipid storage#GO:0019915;cellular component organization or biogenesis#GO:0071840;organelle assembly#GO:0070925;lipid droplet organization#GO:0034389;chemical homeostasis#GO:0048878 organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum membrane#GO:0005789;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane#GO:0016020 phosphatase#PC00181;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=29466|UniProtKB=Q5T753 Q5T753 LCE1E PTHR48615:SF6 LATE CORNIFIED ENVELOPE PROTEIN 1C LATE CORNIFIED ENVELOPE PROTEIN 1A-RELATED HUMAN|HGNC=37175|UniProtKB=A6NCW0 A6NCW0 USP17L3 PTHR24006:SF651 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE INACTIVE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 17-LIKE PROTEIN 4-RELATED hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity, acting on a protein#GO:0140096;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;cysteine-type deubiquitinase activity#GO:0004843 regulation of cellular process#GO:0050794;regulation of biological quality#GO:0065008;biological regulation#GO:0065007;regulation of programmed cell death#GO:0043067;regulation of apoptotic process#GO:0042981;regulation of protein stability#GO:0031647;regulation of biological process#GO:0050789 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;cytosol#GO:0005829 protease#PC00190;cysteine protease#PC00081 HUMAN|HGNC=24475|UniProtKB=Q9UI17 Q9UI17 DMGDH PTHR13847:SF187 SARCOSINE DEHYDROGENASE-RELATED DIMETHYLGLYCINE DEHYDROGENASE, MITOCHONDRIAL oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233 dehydrogenase#PC00092 HUMAN|HGNC=16384|UniProtKB=Q13263 Q13263 TRIM28 PTHR25462:SF308 BONUS, ISOFORM C-RELATED TRANSCRIPTION INTERMEDIARY FACTOR 1-BETA catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;chromatin binding#GO:0003682;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;binding#GO:0005488;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;immune response#GO:0006955;regulation of nucleobase-containing compound metabolic process#GO:0019219;response to other organism#GO:0051707;post-translational protein modification#GO:0043687;negative regulation of biosynthetic process#GO:0009890;chromatin organization#GO:0006325;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;innate immune response#GO:0045087;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;defense response#GO:0006952;regulation of gene expression#GO:0010468;response to external stimulus#GO:0009605;primary metabolic process#GO:0044238;protein modification process#GO:0036211;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;response to external biotic stimulus#GO:0043207;protein metabolic process#GO:0019538;regulation of DNA-templated transcription#GO:0006355;macromolecule modification#GO:0043412;regulation of RNA metabolic process#GO:0051252;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;defense response to symbiont#GO:0140546;defense response to other organism#GO:0098542;metabolic process#GO:0008152;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;cellular component organization or biogenesis#GO:0071840;protein sumoylation#GO:0016925;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;protein modification by small protein conjugation#GO:0032446;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;negative regulation of metabolic process#GO:0009892;biological process involved in interspecies interaction between organisms#GO:0044419;immune system process#GO:0002376;protein modification by small protein conjugation or removal#GO:0070647;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934 RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=9500|UniProtKB=O43653 O43653 PSCA PTHR16983:SF1 UPAR/LY6 DOMAIN-CONTAINING PROTEIN PROSTATE STEM CELL ANTIGEN neurotransmitter receptor regulator activity#GO:0099602;molecular function regulator activity#GO:0098772;protein binding#GO:0005515;acetylcholine receptor regulator activity#GO:0030548;signaling receptor regulator activity#GO:0030545;signaling receptor binding#GO:0005102;binding#GO:0005488 response to nitrogen compound#GO:1901698;cell communication#GO:0007154;response to oxygen-containing compound#GO:1901700;cellular response to chemical stimulus#GO:0070887;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;acetylcholine receptor signaling pathway#GO:0095500;cellular response to nitrogen compound#GO:1901699;response to chemical#GO:0042221;cellular process#GO:0009987;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;synaptic signaling#GO:0099536 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 protein-binding activity modulator#PC00095 HUMAN|HGNC=30958|UniProtKB=Q969S3 Q969S3 ZNF622 PTHR13182:SF8 ZINC FINGER PROTEIN 622 CYTOPLASMIC 60S SUBUNIT BIOGENESIS FACTOR ZNF622 protein-containing complex binding#GO:0044877;ribonucleoprotein complex binding#GO:0043021;binding#GO:0005488 cellular process#GO:0009987;ribosome biogenesis#GO:0042254;ribosomal large subunit biogenesis#GO:0042273;cellular component biogenesis#GO:0044085;ribonucleoprotein complex biogenesis#GO:0022613;cellular component organization or biogenesis#GO:0071840 cytosol#GO:0005829;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;ribonucleoprotein complex#GO:1990904;preribosome#GO:0030684;intracellular anatomical structure#GO:0005622;preribosome, large subunit precursor#GO:0030687 RNA metabolism protein#PC00031 HUMAN|HGNC=6155|UniProtKB=P05107 P05107 ITGB2 PTHR10082:SF15 INTEGRIN BETA SUBUNIT INTEGRIN BETA-2 cell adhesion molecule binding#GO:0050839;integrin binding#GO:0005178;enzyme binding#GO:0019899;peptide binding#GO:0042277;protein kinase binding#GO:0019901;signaling receptor binding#GO:0005102;binding#GO:0005488;kinase binding#GO:0019900;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 chemotaxis#GO:0006935;cell chemotaxis#GO:0060326;cell-substrate adhesion#GO:0031589;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;locomotion#GO:0040011;regulation of cellular process#GO:0050794;cell motility#GO:0048870;cell adhesion mediated by integrin#GO:0033627;leukocyte migration#GO:0050900;leukocyte chemotaxis#GO:0030595;response to external stimulus#GO:0009605;myeloid leukocyte migration#GO:0097529;biological regulation#GO:0065007;cell migration#GO:0016477;cell adhesion#GO:0007155;cell-matrix adhesion#GO:0007160;cellular response to chemical stimulus#GO:0070887;immune system process#GO:0002376;regulation of biological process#GO:0050789;integrin-mediated signaling pathway#GO:0007229;signaling#GO:0023052;response to stimulus#GO:0050896;granulocyte chemotaxis#GO:0071621;cell surface receptor signaling pathway#GO:0007166;neutrophil chemotaxis#GO:0030593;cellular process#GO:0009987;signal transduction#GO:0007165;leukocyte cell-cell adhesion#GO:0007159;cell-cell adhesion#GO:0098609;granulocyte migration#GO:0097530;taxis#GO:0042330;neutrophil migration#GO:1990266;response to chemical#GO:0042221 signaling receptor complex#GO:0043235;integrin complex#GO:0008305;cell junction#GO:0030054;anchoring junction#GO:0070161;membrane#GO:0016020;membrane protein complex#GO:0098796;protein complex involved in cell adhesion#GO:0098636;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;plasma membrane#GO:0005886;cell-substrate junction#GO:0030055;focal adhesion#GO:0005925 integrin#PC00126 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Integrin#P00853;Integrin signalling pathway#P00034>Integrin beta#P00931 HUMAN|HGNC=25531|UniProtKB=Q96K12 Q96K12 FAR2 PTHR11011:SF120 MALE STERILITY PROTEIN 2-RELATED FATTY ACYL-COA REDUCTASE 2 oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the aldehyde or oxo group of donors#GO:0016903;catalytic activity#GO:0003824;oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor#GO:0016620 nucleoside phosphate metabolic process#GO:0006753;nucleobase-containing compound metabolic process#GO:0006139;small molecule metabolic process#GO:0044281;cellular process#GO:0009987;purine-containing compound metabolic process#GO:0072521;sulfur compound metabolic process#GO:0006790;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;organophosphate metabolic process#GO:0019637;nucleobase-containing small molecule metabolic process#GO:0055086;acyl-CoA metabolic process#GO:0006637;lipid metabolic process#GO:0006629;metabolic process#GO:0008152 microbody#GO:0042579;peroxisome#GO:0005777;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;peroxisomal membrane#GO:0005778;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588 HUMAN|HGNC=18485|UniProtKB=Q9HC36 Q9HC36 MRM3 PTHR43191:SF2 RRNA METHYLTRANSFERASE 3, RRNA METHYLTRANSFERASE 3, MITOCHONDRIAL RNA methyltransferase#PC00033;RNA metabolism protein#PC00031 HUMAN|HGNC=32483|UniProtKB=P0C6T2 P0C6T2 OST4 PTHR48164:SF1 DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 4 DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 4 protein N-linked glycosylation#GO:0006487;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;biosynthetic process#GO:0009058;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;transferase complex#GO:1990234;organelle membrane#GO:0031090;endoplasmic reticulum protein-containing complex#GO:0140534;membrane#GO:0016020;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;membrane protein complex#GO:0098796;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;intracellular membrane-bounded organelle#GO:0043231;oligosaccharyltransferase complex#GO:0008250 protein modifying enzyme#PC00260 HUMAN|HGNC=27806|UniProtKB=Q5GH73 Q5GH73 XKR6 PTHR16024:SF9 XK-RELATED PROTEIN XK-RELATED PROTEIN 6 localization#GO:0051179;anatomical structure development#GO:0048856;plasma membrane phospholipid scrambling#GO:0017121;lipid translocation#GO:0034204;organophosphate ester transport#GO:0015748;cell death#GO:0008219;programmed cell death#GO:0012501;regulation of membrane lipid distribution#GO:0097035;establishment of localization#GO:0051234;developmental process#GO:0032502;transport#GO:0006810;phagocytosis#GO:0006909;membrane organization#GO:0061024;biological regulation#GO:0065007;phospholipid transport#GO:0015914;phospholipid translocation#GO:0045332;lipid transport#GO:0006869;macromolecule localization#GO:0033036;regulation of biological quality#GO:0065008;plasma membrane organization#GO:0007009;lipid localization#GO:0010876;endocytosis#GO:0006897;execution phase of apoptosis#GO:0097194;apoptotic process#GO:0006915;cellular component organization#GO:0016043;phagocytosis, engulfment#GO:0006911;apoptotic cell clearance#GO:0043277;cellular component organization or biogenesis#GO:0071840;import into cell#GO:0098657;membrane invagination#GO:0010324;endomembrane system organization#GO:0010256;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 secondary carrier transporter#PC00258 HUMAN|HGNC=804|UniProtKB=P05026 P05026 ATP1B1 PTHR11523:SF10 SODIUM/POTASSIUM-DEPENDENT ATPASE BETA SUBUNIT SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA-1 molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;ATPase activator activity#GO:0001671 intracellular chemical homeostasis#GO:0055082;inorganic cation import across plasma membrane#GO:0098659;cellular homeostasis#GO:0019725;potassium ion import across plasma membrane#GO:1990573;establishment of localization#GO:0051234;import into cell#GO:0098657;chemical homeostasis#GO:0048878;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801;monoatomic ion transport#GO:0006811;potassium ion homeostasis#GO:0055075;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;inorganic ion homeostasis#GO:0098771;homeostatic process#GO:0042592;metal ion transport#GO:0030001;export from cell#GO:0140352;inorganic ion import across plasma membrane#GO:0099587;import across plasma membrane#GO:0098739;sodium ion transport#GO:0006814;intracellular monoatomic ion homeostasis#GO:0006873 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane protein complex#GO:0098796;membrane#GO:0016020;cell periphery#GO:0071944;cation-transporting ATPase complex#GO:0090533;plasma membrane protein complex#GO:0098797;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;ATPase dependent transmembrane transport complex#GO:0098533 primary active transporter#PC00068;transporter#PC00227 HUMAN|HGNC=3765|UniProtKB=P36888 P36888 FLT3 PTHR24416:SF356 TYROSINE-PROTEIN KINASE RECEPTOR RECEPTOR-TYPE TYROSINE-PROTEIN KINASE FLT3 kinase activity#GO:0016301;transferase activity#GO:0016740;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488;protein kinase activity#GO:0004672;protein binding#GO:0005515;phosphotransferase activity, alcohol group as acceptor#GO:0016773;growth factor binding#GO:0019838;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein tyrosine kinase activity#GO:0004713;catalytic activity#GO:0003824;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity, acting on a protein#GO:0140096;transmembrane receptor protein tyrosine kinase activity#GO:0004714;molecular transducer activity#GO:0060089 signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;response to chemical#GO:0042221;response to cytokine#GO:0034097;lymphocyte activation#GO:0046649;cell surface receptor signaling pathway#GO:0007166;B cell activation#GO:0042113;positive regulation of cell population proliferation#GO:0008284;leukocyte differentiation#GO:0002521;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;mononuclear cell differentiation#GO:1903131;cell differentiation#GO:0030154;response to stimulus#GO:0050896;signaling#GO:0023052;cell development#GO:0048468;immune system process#GO:0002376;response to peptide#GO:1901652;positive regulation of cellular process#GO:0048522;cell migration#GO:0016477;multicellular organismal process#GO:0032501;hemopoiesis#GO:0030097;biological regulation#GO:0065007;developmental process#GO:0032502;cellular developmental process#GO:0048869;leukocyte activation#GO:0045321;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;cell motility#GO:0048870;cytokine-mediated signaling pathway#GO:0019221;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;lymphocyte differentiation#GO:0030098;cell activation#GO:0001775;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167 signaling receptor complex#GO:0043235;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 transmembrane signal receptor#PC00197 HUMAN|HGNC=3683|UniProtKB=P12034 P12034 FGF5 PTHR11486:SF23 FIBROBLAST GROWTH FACTOR FIBROBLAST GROWTH FACTOR 5 molecular function activator activity#GO:0140677;protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;fibroblast growth factor receptor binding#GO:0005104;signaling receptor regulator activity#GO:0030545;growth factor activity#GO:0008083;growth factor receptor binding#GO:0070851;receptor ligand activity#GO:0048018 neurogenesis#GO:0022008;positive regulation of MAPK cascade#GO:0043410;cellular developmental process#GO:0048869;developmental process#GO:0032502;positive regulation of intracellular signal transduction#GO:1902533;regulation of cell migration#GO:0030334;regulation of response to stimulus#GO:0048583;response to fibroblast growth factor#GO:0071774;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;positive regulation of response to stimulus#GO:0048584;multicellular organismal process#GO:0032501;fibroblast growth factor receptor signaling pathway#GO:0008543;positive regulation of cellular process#GO:0048522;system development#GO:0048731;regulation of cell motility#GO:2000145;regulation of cell population proliferation#GO:0042127;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of cell communication#GO:0010646;response to growth factor#GO:0070848;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;multicellular organism development#GO:0007275;regulation of MAPK cascade#GO:0043408;cell surface receptor signaling pathway#GO:0007166;nervous system development#GO:0007399;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular response to fibroblast growth factor stimulus#GO:0044344;cellular process#GO:0009987;cellular response to growth factor stimulus#GO:0071363;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;animal gross anatomical part developmental process#GO:0160108;regulation of intracellular signal transduction#GO:1902531;signaling#GO:0023052;cell differentiation#GO:0030154;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;positive regulation of cell population proliferation#GO:0008284;response to endogenous stimulus#GO:0009719 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 growth factor#PC00112;intercellular signal molecule#PC00207 FGF signaling pathway#P00021>FGF#P00623 HUMAN|HGNC=8013|UniProtKB=P82970 P82970 HMGN5 PTHR23145:SF6 NUCLEOSOMAL BINDING PROTEIN 1 HIGH MOBILITY GROUP NUCLEOSOME-BINDING DOMAIN-CONTAINING PROTEIN 5 HUMAN|HGNC=24474|UniProtKB=Q9H0N5 Q9H0N5 PCBD2 PTHR12599:SF15 PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE 2 dehydratase#PC00091;lyase#PC00144 HUMAN|HGNC=343|UniProtKB=P23526 P23526 AHCY PTHR23420:SF34 ADENOSYLHOMOCYSTEINASE ADENOSYLHOMOCYSTEINASE hydrolase activity#GO:0016787;catalytic activity#GO:0003824 oxoacid metabolic process#GO:0043436;purine nucleoside metabolic process#GO:0042278;modified amino acid metabolic process#GO:0006575;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;purine-containing compound metabolic process#GO:0072521;nucleoside metabolic process#GO:0009116;small molecule metabolic process#GO:0044281;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;sulfur compound metabolic process#GO:0006790;cellular process#GO:0009987;homocysteine metabolic process#GO:0050667;carbohydrate derivative metabolic process#GO:1901135;proteinogenic amino acid metabolic process#GO:0170039;amino acid metabolic process#GO:0006520;nucleobase-containing compound metabolic process#GO:0006139 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 hydrolase#PC00121;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=25221|UniProtKB=Q9H3L0 Q9H3L0 MMADHC PTHR13192:SF3 MY011 PROTEIN COBALAMIN TRAFFICKING PROTEIN CBLD metabolic process#GO:0008152;tetrapyrrole metabolic process#GO:0033013;cellular process#GO:0009987 mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=31299|UniProtKB=A6NIJ9 A6NIJ9 OR6C70 PTHR26454:SF17 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 6C70 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=2941|UniProtKB=Q8IVF4 Q8IVF4 DNAH10 PTHR10676:SF343 DYNEIN HEAVY CHAIN FAMILY PROTEIN DYNEIN AXONEMAL HEAVY CHAIN 10 isomerase activity#GO:0016853;cytoskeletal motor activity#GO:0003774;macromolecular conformation isomerase activity#GO:0120543;catalytic activity#GO:0003824;microtubule motor activity#GO:0003777;protein binding#GO:0005515;ATP-dependent activity#GO:0140657;polypeptide conformation or assembly isomerase activity#GO:0120544;binding#GO:0005488 cilium movement involved in cell motility#GO:0060294;cellular process#GO:0009987;microtubule-based movement#GO:0007018;cell motility#GO:0048870;cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;cilium-dependent cell motility#GO:0060285;microtubule-based process#GO:0007017 membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;9+2 motile cilium#GO:0097729;cilium#GO:0005929;cellular anatomical structure#GO:0110165;motile cilium#GO:0031514;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;dynein complex#GO:0030286 microtubule or microtubule-binding cytoskeletal protein#PC00157;microtubule binding motor protein#PC00156 Huntington disease#P00029>Dynein complex#P00774 HUMAN|HGNC=10952|UniProtKB=Q9UIG8 Q9UIG8 SLCO3A1 PTHR11388:SF86 ORGANIC ANION TRANSPORTER SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 3A1 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;secondary active transmembrane transporter activity#GO:0015291;active transmembrane transporter activity#GO:0022804 macromolecule localization#GO:0033036;cellular process#GO:0009987;lipid transport#GO:0006869;lipid localization#GO:0010876;organic acid transport#GO:0015849;transport#GO:0006810;carboxylic acid transport#GO:0046942;localization#GO:0051179;fatty acid transport#GO:0015908;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;monocarboxylic acid transport#GO:0015718 plasma membrane#GO:0005886;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;basal plasma membrane#GO:0009925;cell periphery#GO:0071944;basal part of cell#GO:0045178;basolateral plasma membrane#GO:0016323;membrane#GO:0016020 transporter#PC00227 HUMAN|HGNC=14894|UniProtKB=Q9BZM5 Q9BZM5 ULBP2 PTHR16675:SF148 MHC CLASS I-RELATED UL16-BINDING PROTEIN 2-RELATED signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;molecular function activator activity#GO:0140677;protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488 regulation of immune response#GO:0050776;positive regulation of lymphocyte mediated immunity#GO:0002708;regulation of immune effector process#GO:0002697;antigen processing and presentation#GO:0019882;regulation of leukocyte mediated cytotoxicity#GO:0001910;regulation of leukocyte mediated immunity#GO:0002703;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;response to external biotic stimulus#GO:0043207;positive regulation of leukocyte mediated immunity#GO:0002705;cell killing#GO:0001906;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;innate immune response#GO:0045087;response to external stimulus#GO:0009605;defense response#GO:0006952;immune response#GO:0006955;positive regulation of cellular process#GO:0048522;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;positive regulation of immune effector process#GO:0002699;response to other organism#GO:0051707;immune system process#GO:0002376;regulation of lymphocyte mediated immunity#GO:0002706;regulation of cell killing#GO:0031341;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449;leukocyte mediated cytotoxicity#GO:0001909;natural killer cell mediated immunity#GO:0002228;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;positive regulation of adaptive immune response#GO:0002821;biological process involved in interspecies interaction between organisms#GO:0044419;immune effector process#GO:0002252;natural killer cell mediated cytotoxicity#GO:0042267;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;positive regulation of immune system process#GO:0002684;positive regulation of biological process#GO:0048518;defense response to symbiont#GO:0140546;cellular process#GO:0009987;defense response to other organism#GO:0098542 side of membrane#GO:0098552;extracellular region#GO:0005576;external side of plasma membrane#GO:0009897;plasma membrane#GO:0005886;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 major histocompatibility complex protein#PC00149;defense/immunity protein#PC00090 HUMAN|HGNC=15684|UniProtKB=Q9BYG0 Q9BYG0 B3GNT5 PTHR11214:SF21 BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE LACTOSYLCERAMIDE 1,3-N-ACETYL-BETA-D-GLUCOSAMINYLTRANSFERASE glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;transferase activity#GO:0016740 bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020 transferase#PC00220;glycosyltransferase#PC00111 HUMAN|HGNC=11047|UniProtKB=Q9UN76 Q9UN76 SLC6A14 PTHR11616:SF286 SODIUM/CHLORIDE DEPENDENT TRANSPORTER SODIUM- AND CHLORIDE-DEPENDENT NEUTRAL AND BASIC AMINO ACID TRANSPORTER B(0+) symporter activity#GO:0015293;monoatomic cation transmembrane transporter activity#GO:0008324;amino acid transmembrane transporter activity#GO:0015171;branched-chain amino acid transmembrane transporter activity#GO:0015658;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;quaternary ammonium group transmembrane transporter activity#GO:0015651;carboxylic acid transmembrane transporter activity#GO:0046943;solute:sodium symporter activity#GO:0015370;amino acid:sodium symporter activity#GO:0005283;transmembrane transporter activity#GO:0022857;neutral L-amino acid transmembrane transporter activity#GO:0015175;solute:monoatomic cation symporter activity#GO:0015294;sodium ion transmembrane transporter activity#GO:0015081;active transmembrane transporter activity#GO:0022804 carboxylic acid transport#GO:0046942;amino acid transport#GO:0006865;transport#GO:0006810;organic acid transport#GO:0015849;import into cell#GO:0098657;establishment of localization#GO:0051234;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;quaternary ammonium group transport#GO:0015697;nitrogen compound transport#GO:0071705;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;glycine transport#GO:0015816;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;amino acid transmembrane transport#GO:0003333;neutral amino acid transport#GO:0015804;transmembrane transport#GO:0055085;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;carboxylic acid transmembrane transport#GO:1905039;import across plasma membrane#GO:0098739 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 primary active transporter#PC00068 HUMAN|HGNC=26150|UniProtKB=Q53R41 Q53R41 FASTKD1 PTHR21228:SF29 FAST LEU-RICH DOMAIN-CONTAINING FAST KINASE DOMAIN-CONTAINING PROTEIN 1, MITOCHONDRIAL binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 regulation of mRNA catabolic process#GO:0061013;regulation of biological process#GO:0050789;regulation of mRNA stability#GO:0043488;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;regulation of biological quality#GO:0065008;cellular process#GO:0009987;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;regulation of mRNA metabolic process#GO:1903311;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;RNA biosynthetic process#GO:0032774;regulation of RNA stability#GO:0043487;mitochondrial RNA metabolic process#GO:0000959;regulation of RNA metabolic process#GO:0051252;mitochondrial gene expression#GO:0140053;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;macromolecule biosynthetic process#GO:0009059;mitochondrial RNA processing#GO:0000963;regulation of nucleobase-containing compound metabolic process#GO:0019219;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;post-transcriptional regulation of gene expression#GO:0010608;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468 supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;membraneless organelle#GO:0043228;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229 RNA processing factor#PC00147 HUMAN|HGNC=8196|UniProtKB=Q96R84 Q96R84 OR1F2P PTHR48001:SF98 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 1F1-RELATED olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=13771|UniProtKB=Q9BQB4 Q9BQB4 SOST PTHR14903:SF4 SCLEROSTIN-RELATED SCLEROSTIN binding#GO:0005488;cytokine binding#GO:0019955;protein binding#GO:0005515 negative regulation of cell communication#GO:0010648;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;regulation of cellular process#GO:0050794;ossification#GO:0001503;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of BMP signaling pathway#GO:0030514;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;multicellular organismal process#GO:0032501;negative regulation of response to stimulus#GO:0048585;negative regulation of Wnt signaling pathway#GO:0030178;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cellular response to growth factor stimulus#GO:0090287;negative regulation of signal transduction#GO:0009968;regulation of BMP signaling pathway#GO:0030510 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HUMAN|HGNC=19026|UniProtKB=Q8NFW5 Q8NFW5 DMBX1 PTHR46639:SF2 DIENCEPHALON/MESENCEPHALON HOMEOBOX PROTEIN 1 DIENCEPHALON_MESENCEPHALON HOMEOBOX PROTEIN 1 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=13812|UniProtKB=Q9NY64 Q9NY64 SLC2A8 PTHR48021:SF18 FAMILY NOT NAMED SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 8 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;carbohydrate transmembrane transporter activity#GO:0015144;sugar transmembrane transporter activity#GO:0051119 cellular process#GO:0009987;D-glucose transmembrane transport#GO:1904659;carbohydrate transmembrane transport#GO:0034219;transport#GO:0006810;carbohydrate transport#GO:0008643;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179 cellular anatomical structure#GO:0110165;membrane#GO:0016020 HUMAN|HGNC=5154|UniProtKB=P15428 P15428 HPGD PTHR44229:SF11 15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)] 15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)] oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824 prostaglandin metabolic process#GO:0006693;unsaturated fatty acid metabolic process#GO:0033559;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;fatty acid metabolic process#GO:0006631;reproductive process#GO:0022414;small molecule metabolic process#GO:0044281;icosanoid metabolic process#GO:0006690;multicellular organismal process#GO:0032501;multi-multicellular organism process#GO:0044706;cellular process#GO:0009987;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238 plasma membrane#GO:0005886;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;basal plasma membrane#GO:0009925;cell periphery#GO:0071944;basolateral plasma membrane#GO:0016323;basal part of cell#GO:0045178;membrane#GO:0016020;extracellular region#GO:0005576 metabolite interconversion enzyme#PC00262;dehydrogenase#PC00092;oxidoreductase#PC00176 HUMAN|HGNC=19260|UniProtKB=Q9NPC1 Q9NPC1 LTB4R2 PTHR24230:SF8 G-PROTEIN COUPLED RECEPTOR LEUKOTRIENE B4 RECEPTOR 2 G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 neuropeptide signaling pathway#GO:0007218;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CHKR#P00854 HUMAN|HGNC=2050|UniProtKB=P56748 P56748 CLDN8 PTHR12002:SF24 CLAUDIN CLAUDIN-8 transporter activity#GO:0005215;paracellular tight junction channel activity#GO:0160187 cell junction organization#GO:0034330;cellular component assembly#GO:0022607;cellular process#GO:0009987;cellular component organization#GO:0016043;cell junction assembly#GO:0034329;cellular component biogenesis#GO:0044085;establishment of localization#GO:0051234;paracellular transport#GO:0160184;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;cell-cell junction assembly#GO:0007043;transport#GO:0006810;cell-cell junction organization#GO:0045216 cell periphery#GO:0071944;cell-cell junction#GO:0005911;membrane#GO:0016020;plasma membrane#GO:0005886;bicellular tight junction#GO:0005923;cellular anatomical structure#GO:0110165;apical junction complex#GO:0043296;anchoring junction#GO:0070161;cell junction#GO:0030054;tight junction#GO:0070160 cell junction protein#PC00070;tight junction#PC00214 HUMAN|HGNC=29210|UniProtKB=Q8N344 Q8N344 MIER2 PTHR10865:SF27 METASTASIS-ASSOCIATED PROTEIN AND MESODERM INDUCTION EARLY RESPONSE PROTEIN MESODERM INDUCTION EARLY RESPONSE PROTEIN 2 histone deacetylase binding#GO:0042826;protein binding#GO:0005515;transcription corepressor activity#GO:0003714;binding#GO:0005488;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;enzyme binding#GO:0019899 biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892 cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=25588|UniProtKB=Q96FL8 Q96FL8 SLC47A1 PTHR11206:SF73 MULTIDRUG RESISTANCE PROTEIN MULTIDRUG AND TOXIN EXTRUSION PROTEIN 1 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;xenobiotic transmembrane transporter activity#GO:0042910 transport#GO:0006810;cellular process#GO:0009987;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085 cellular anatomical structure#GO:0110165;membrane#GO:0016020 transporter#PC00227 HUMAN|HGNC=1393|UniProtKB=O60840 O60840 CACNA1F PTHR45628:SF2 VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1 VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;voltage-gated channel activity#GO:0022832;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261;channel activity#GO:0015267;voltage-gated calcium channel activity#GO:0005245 monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;inorganic ion import across plasma membrane#GO:0099587;metal ion transport#GO:0030001;import across plasma membrane#GO:0098739;calcium ion import#GO:0070509;calcium ion transmembrane transport#GO:0070588;inorganic cation import across plasma membrane#GO:0098659;calcium ion transport#GO:0006816;establishment of localization#GO:0051234;import into cell#GO:0098657;calcium ion transmembrane import into cytosol#GO:0097553;transport#GO:0006810;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;cellular process#GO:0009987 cation channel complex#GO:0034703;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;voltage-gated calcium channel complex#GO:0005891;membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;calcium channel complex#GO:0034704;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;plasma membrane#GO:0005886 voltage-gated ion channel#PC00241 Nicotinic acetylcholine receptor signaling pathway#P00044>Ca2+ channel#P01096;Gonadotropin-releasing hormone receptor pathway#P06664>L-type Ca2+#P06812;5HT2 type receptor mediated signaling pathway#P04374>Ca2+ channel#P04411;Beta2 adrenergic receptor signaling pathway#P04378>Ca2+ channel#P04445;Beta1 adrenergic receptor signaling pathway#P04377>Ca2+ channel#P04438;Oxytocin receptor mediated signaling pathway#P04391>Ca2+ channel#P04535;Alzheimer disease-amyloid secretase pathway#P00003>L-type calcium channels#P00082 HUMAN|HGNC=643|UniProtKB=O43315 O43315 AQP9 PTHR43829:SF6 AQUAPORIN OR AQUAGLYCEROPORIN RELATED AQUAPORIN-9 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;water channel activity#GO:0015250;water transmembrane transporter activity#GO:0005372;passive transmembrane transporter activity#GO:0022803;carbohydrate transmembrane transporter activity#GO:0015144;channel activity#GO:0015267 carbohydrate transport#GO:0008643;transport#GO:0006810;fluid transport#GO:0042044;organic hydroxy compound transport#GO:0015850;water transport#GO:0006833;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;cellular process#GO:0009987;carbohydrate transmembrane transport#GO:0034219 plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;basal part of cell#GO:0045178;basolateral plasma membrane#GO:0016323;membrane#GO:0016020;basal plasma membrane#GO:0009925;cell periphery#GO:0071944 transporter#PC00227 HUMAN|HGNC=2420|UniProtKB=O95825 O95825 CRYZL1 PTHR44461:SF1 QUINONE OXIDOREDUCTASE-LIKE PROTEIN 1 FERRY ENDOSOMAL RAB5 EFFECTOR COMPLEX SUBUNIT 4 oxidoreductase#PC00176 HUMAN|HGNC=16736|UniProtKB=Q86Y25 Q86Y25 ZNF354C PTHR24377:SF991 IP01015P-RELATED ZINC FINGER PROTEIN 354C DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=5147|UniProtKB=P32754 P32754 HPD PTHR11959:SF12 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE catalytic activity#GO:0003824;oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen#GO:0016702;dioxygenase activity#GO:0051213;oxidoreductase activity#GO:0016491 small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;proteinogenic amino acid metabolic process#GO:0170039;small molecule catabolic process#GO:0044282;amino acid metabolic process#GO:0006520;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152 membrane#GO:0016020;endomembrane system#GO:0012505;cytoplasm#GO:0005737;endoplasmic reticulum membrane#GO:0005789;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;endoplasmic reticulum#GO:0005783;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227 oxygenase#PC00177;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=8477|UniProtKB=Q15620 Q15620 OR8B8 PTHR48018:SF7 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 8B8 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;nervous system process#GO:0050877;sensory perception#GO:0007600;sensory perception of smell#GO:0007608;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=4747|UniProtKB=P58876 P58876 H2BC5 PTHR23428:SF250 HISTONE H2B HISTONE H2B TYPE 1-D response to other organism#GO:0051707;defense response to other organism#GO:0098542;immune response#GO:0006955;defense response to symbiont#GO:0140546;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;response to external stimulus#GO:0009605;defense response#GO:0006952;antibacterial humoral response#GO:0019731;innate immune response#GO:0045087;humoral immune response#GO:0006959;antimicrobial humoral response#GO:0019730;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to stimulus#GO:0050896;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;defense response to bacterium#GO:0042742;immune system process#GO:0002376;response to bacterium#GO:0009617 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=21097|UniProtKB=Q96AQ8 Q96AQ8 MCUR1 PTHR14360:SF11 PROTEIN FMP32, MITOCHONDRIAL MITOCHONDRIAL CALCIUM UNIPORTER REGULATOR 1 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 cellular process#GO:0009987;mitochondrial calcium ion transmembrane transport#GO:0006851;monoatomic ion homeostasis#GO:0050801;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;chemical homeostasis#GO:0048878;transport#GO:0006810;intracellular calcium ion homeostasis#GO:0006874;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;calcium ion transport#GO:0006816;establishment of localization#GO:0051234;intracellular monoatomic ion homeostasis#GO:0006873;calcium ion transmembrane transport#GO:0070588;homeostatic process#GO:0042592;metal ion transport#GO:0030001;mitochondrial calcium ion homeostasis#GO:0051560;inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020 HUMAN|HGNC=30402|UniProtKB=Q9BQF6 Q9BQF6 SENP7 PTHR46896:SF2 SENTRIN-SPECIFIC PROTEASE SENTRIN-SPECIFIC PROTEASE 7 hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;endopeptidase activity#GO:0004175;cysteine-type endopeptidase activity#GO:0004197;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234 metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647;macromolecule metabolic process#GO:0043170;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;protein modification process#GO:0036211;cellular process#GO:0009987;post-translational protein modification#GO:0043687 nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 protease#PC00190;cysteine protease#PC00081 HUMAN|HGNC=9767|UniProtKB=O00194 O00194 RAB27B PTHR47977:SF33 RAS-RELATED PROTEIN RAB RAS-RELATED PROTEIN RAB-27B ribonucleotide binding#GO:0032553;hydrolase activity, acting on acid anhydrides#GO:0016817;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;guanyl nucleotide binding#GO:0019001;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;nucleoside phosphate binding#GO:1901265;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;anion binding#GO:0043168;GTPase activity#GO:0003924;ion binding#GO:0043167;hydrolase activity#GO:0016787 secretion by cell#GO:0032940;regulation of exocytosis#GO:0017157;regulation of secretion by cell#GO:1903530;localization#GO:0051179;regulation of secretion#GO:0051046;secretion#GO:0046903;positive regulation of secretion#GO:0051047;export from cell#GO:0140352;regulation of cellular process#GO:0050794;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;regulation of transport#GO:0051049;exocytosis#GO:0006887;regulation of localization#GO:0032879;establishment of localization#GO:0051234;transport#GO:0006810;biological regulation#GO:0065007;vesicle-mediated transport#GO:0016192;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of transport#GO:0051050;positive regulation of secretion by cell#GO:1903532;cellular process#GO:0009987 Golgi apparatus#GO:0005794;apical part of cell#GO:0045177;endomembrane system#GO:0012505;plasma membrane region#GO:0098590;transport vesicle#GO:0030133;cytoplasm#GO:0005737;plasma membrane#GO:0005886;membrane#GO:0016020;secretory vesicle#GO:0099503;cell periphery#GO:0071944;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;apical plasma membrane#GO:0016324;vesicle#GO:0031982 small GTPase#PC00208 HUMAN|HGNC=25380|UniProtKB=Q8TC26 Q8TC26 TMEM163 PTHR31937:SF2 TRANSMEMBRANE PROTEIN 163 TRANSMEMBRANE PROTEIN 163 metal ion binding#GO:0046872;cation binding#GO:0043169;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;zinc ion binding#GO:0008270;transition metal ion binding#GO:0046914 intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular vesicle#GO:0097708;vesicle#GO:0031982;synaptic vesicle membrane#GO:0030672;synaptic vesicle#GO:0008021;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cell junction#GO:0030054;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;membrane#GO:0016020;secretory vesicle#GO:0099503;presynapse#GO:0098793;transport vesicle#GO:0030133;transport vesicle membrane#GO:0030658;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;cytoplasm#GO:0005737 HUMAN|HGNC=25540|UniProtKB=Q9HCE6 Q9HCE6 ARHGEF10L PTHR12877:SF16 RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 10-LIKE PROTEIN guanyl-nucleotide exchange factor activity#GO:0005085;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772 positive regulation of actin filament bundle assembly#GO:0032233;regulation of actin filament-based process#GO:0032970;biological regulation#GO:0065007;SREBP signaling pathway#GO:0032933;positive regulation of cellular process#GO:0048522;regulation of actin filament organization#GO:0110053;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;actin filament-based process#GO:0030029;regulation of stress fiber assembly#GO:0051492;regulation of cytoskeleton organization#GO:0051493;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;regulation of supramolecular fiber organization#GO:1902903;cellular response to stimulus#GO:0051716;cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010;regulation of actin cytoskeleton organization#GO:0032956;positive regulation of cellular component biogenesis#GO:0044089;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;organelle organization#GO:0006996;response to stress#GO:0006950;positive regulation of organelle organization#GO:0010638;positive regulation of cellular component organization#GO:0051130;cellular response to stress#GO:0033554;signaling#GO:0023052;regulation of cellular component biogenesis#GO:0044087;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;regulation of actin filament bundle assembly#GO:0032231;cellular component organization#GO:0016043 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HUMAN|HGNC=4893|UniProtKB=P14210 P14210 HGF PTHR24261:SF8 PLASMINOGEN-RELATED HEPATOCYTE GROWTH FACTOR protein binding#GO:0005515;hydrolase activity#GO:0016787;binding#GO:0005488;signaling receptor binding#GO:0005102;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;negative regulation of programmed cell death#GO:0043069;signal transduction#GO:0007165;cellular process#GO:0009987;negative regulation of apoptotic process#GO:0043066;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;regulation of apoptotic process#GO:0042981;cell surface receptor signaling pathway#GO:0007166 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 serine protease#PC00203;protein modifying enzyme#PC00260 HUMAN|HGNC=28987|UniProtKB=Q92615 Q92615 LARP4B PTHR22792:SF43 LUPUS LA PROTEIN-RELATED LA-RELATED PROTEIN 4B mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;mRNA 3'-UTR binding#GO:0003730 RNA metabolism protein#PC00031 HUMAN|HGNC=18272|UniProtKB=Q6P1Q9 Q6P1Q9 METTL2B PTHR22809:SF4 METHYLTRANSFERASE-RELATED TRNA N(3)-CYTIDINE METHYLTRANSFERASE METTL2A-RELATED RNA methyltransferase activity#GO:0008173;catalytic activity, acting on RNA#GO:0140098;tRNA methyltransferase activity#GO:0008175;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on a tRNA#GO:0140101;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757 methyltransferase#PC00155 HUMAN|HGNC=1239|UniProtKB=Q9BXS4 Q9BXS4 TMEM59 PTHR28652:SF3 TRANSMEMBRANE PROTEIN 59-LIKE PROTEIN TRANSMEMBRANE PROTEIN 59 biological regulation#GO:0065007;regulation of cellular process#GO:0050794;positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789;positive regulation of cellular process#GO:0048522;regulation of autophagy#GO:0010506;positive regulation of autophagy#GO:0010508;regulation of metabolic process#GO:0019222;regulation of catabolic process#GO:0009894;positive regulation of metabolic process#GO:0009893;positive regulation of catabolic process#GO:0009896 endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;intracellular vesicle#GO:0097708;lysosome#GO:0005764;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;lytic vacuole#GO:0000323;late endosome#GO:0005770;endomembrane system#GO:0012505;cytoplasm#GO:0005737;vacuole#GO:0005773 HUMAN|HGNC=19966|UniProtKB=Q9P2D8 Q9P2D8 UNC79 PTHR21696:SF2 PROTEIN UNC-79 HOMOLOG PROTEIN UNC-79 HOMOLOG HUMAN|HGNC=15452|UniProtKB=Q9H4A6 Q9H4A6 GOLPH3 PTHR12704:SF3 TRANS-GOLGI PROTEIN GMX33 GOLGI PHOSPHOPROTEIN 3 ion binding#GO:0043167;protein-macromolecule adaptor activity#GO:0030674;small molecule binding#GO:0036094;binding#GO:0005488;anion binding#GO:0043168;lipid binding#GO:0008289;cargo adaptor activity#GO:0140312;molecular adaptor activity#GO:0060090;phospholipid binding#GO:0005543;phosphatidylinositol phosphate binding#GO:1901981 macromolecule localization#GO:0033036;establishment of protein localization to membrane#GO:0090150;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of protein localization#GO:0045184;vesicle-mediated transport#GO:0016192;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;protein localization to cell periphery#GO:1990778;transport#GO:0006810;Golgi vesicle transport#GO:0048193;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;vesicle budding from membrane#GO:0006900;vesicle organization#GO:0016050;vesicle-mediated transport to the plasma membrane#GO:0098876;intracellular protein localization#GO:0008104;cellular component organization#GO:0016043;protein localization to plasma membrane#GO:0072659;protein localization to membrane#GO:0072657;Golgi organization#GO:0007030;Golgi to plasma membrane transport#GO:0006893;Golgi to plasma membrane protein transport#GO:0043001;establishment of protein localization to plasma membrane#GO:0061951;localization within membrane#GO:0051668;cellular localization#GO:0051641;localization#GO:0051179;protein transport#GO:0015031;post-Golgi vesicle-mediated transport#GO:0006892 intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;trans-Golgi network#GO:0005802;Golgi apparatus subcompartment#GO:0098791;cytosol#GO:0005829 HUMAN|HGNC=17999|UniProtKB=Q6P5Z2 Q6P5Z2 PKN3 PTHR24356:SF318 SERINE/THREONINE-PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE N3 catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052 non-receptor serine/threonine protein kinase#PC00167 Alzheimer disease-amyloid secretase pathway#P00003>PKC#P00109;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>PKC#P01074 HUMAN|HGNC=5596|UniProtKB=P01772 P01772 IGHV3-33 PTHR23266:SF241 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 3-30-RELATED antigen binding#GO:0003823;binding#GO:0005488 immune response#GO:0006955;adaptive immune response#GO:0002250;response to stimulus#GO:0050896;immune effector process#GO:0002252;immune system process#GO:0002376;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|Ensembl=ENSG00000276565.1|UniProtKB=A0A0G2JP85 A0A0G2JP85 PTHR35846:SF3 PROTEIN CBG05131 RGS DOMAIN-CONTAINING PROTEIN HUMAN|HGNC=11099|UniProtKB=Q14527 Q14527 HLTF PTHR45626:SF17 TRANSCRIPTION TERMINATION FACTOR 2-RELATED DNA-DEPENDENT ATPASE_E3 UBIQUITIN-PROTEIN LIGASE HLTF catalytic activity, acting on DNA#GO:0140097;ATP-dependent activity, acting on DNA#GO:0008094;ATP-dependent activity#GO:0140657;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 DNA damage response#GO:0006974;cellular response to stress#GO:0033554;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;nucleobase-containing compound metabolic process#GO:0006139;response to stimulus#GO:0050896 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 Wnt signaling pathway#P00057>SWI/SNF#P01435 HUMAN|HGNC=370|UniProtKB=Q02952 Q02952 AKAP12 PTHR23209:SF4 A-KINASE ANCHOR PROTEIN 12 A-KINASE ANCHOR PROTEIN 12 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell communication#GO:0007154 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=10646|UniProtKB=Q9UBD3 Q9UBD3 XCL2 PTHR12015:SF101 SMALL INDUCIBLE CYTOKINE A CYTOKINE SCM-1 BETA-RELATED binding#GO:0005488;signaling receptor binding#GO:0005102;cytokine receptor binding#GO:0005126;cytokine activity#GO:0005125;chemokine receptor binding#GO:0042379;protein binding#GO:0005515;molecular function activator activity#GO:0140677;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;chemokine activity#GO:0008009;G protein-coupled receptor binding#GO:0001664;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772 granulocyte migration#GO:0097530;defense response to other organism#GO:0098542;response to cytokine#GO:0034097;taxis#GO:0042330;response to chemical#GO:0042221;cellular process#GO:0009987;defense response to symbiont#GO:0140546;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;response to stress#GO:0006950;response to chemokine#GO:1990868;response to biotic stimulus#GO:0009607;cell surface receptor signaling pathway#GO:0007166;antimicrobial humoral response#GO:0019730;humoral immune response#GO:0006959;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;granulocyte chemotaxis#GO:0071621;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;positive regulation of cell motility#GO:2000147;response to peptide#GO:1901652;cellular response to chemical stimulus#GO:0070887;immune system process#GO:0002376;G protein-coupled receptor signaling pathway#GO:0007186;regulation of locomotion#GO:0040012;response to other organism#GO:0051707;biological regulation#GO:0065007;cell migration#GO:0016477;positive regulation of cell migration#GO:0030335;immune response#GO:0006955;positive regulation of cellular process#GO:0048522;leukocyte chemotaxis#GO:0030595;defense response#GO:0006952;myeloid leukocyte migration#GO:0097529;positive regulation of locomotion#GO:0040017;response to external stimulus#GO:0009605;regulation of cell migration#GO:0030334;leukocyte migration#GO:0050900;cellular response to chemokine#GO:1990869;locomotion#GO:0040011;response to external biotic stimulus#GO:0043207;cell motility#GO:0048870;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;cell chemotaxis#GO:0060326;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;regulation of cell motility#GO:2000145;cell communication#GO:0007154;chemokine-mediated signaling pathway#GO:0070098;inflammatory response#GO:0006954;chemotaxis#GO:0006935;cytokine-mediated signaling pathway#GO:0019221 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 cytokine#PC00083 HUMAN|HGNC=14903|UniProtKB=Q9BR01 Q9BR01 SULT4A1 PTHR11783:SF274 SULFOTRANSFERASE SULT SULFOTRANSFERASE 4A1 catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring sulphur-containing groups#GO:0016782;sulfotransferase activity#GO:0008146 cellular process#GO:0009987;sulfur compound metabolic process#GO:0006790;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 transferase#PC00220;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=16629|UniProtKB=O95398 O95398 RAPGEF3 PTHR23113:SF24 GUANINE NUCLEOTIDE EXCHANGE FACTOR RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 3 molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;guanyl-nucleotide exchange factor activity#GO:0005085 Ras protein signal transduction#GO:0007265;cell communication#GO:0007154;regulation of angiogenesis#GO:0045765;intracellular signal transduction#GO:0035556;positive regulation of angiogenesis#GO:0045766;cellular response to stimulus#GO:0051716;positive regulation of multicellular organismal process#GO:0051240;regulation of multicellular organismal development#GO:2000026;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of developmental process#GO:0050793;signaling#GO:0023052;regulation of vasculature development#GO:1901342;positive regulation of developmental process#GO:0051094;regulation of anatomical structure morphogenesis#GO:0022603;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;regulation of multicellular organismal process#GO:0051239;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=6910|UniProtKB=O95460 O95460 MATN4 PTHR24020:SF14 COLLAGEN ALPHA MATRILIN-4 extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cellular anatomical structure#GO:0110165 extracellular matrix structural protein#PC00103 HUMAN|Ensembl=ENSG00000288382.1|UniProtKB=A0AB56IDB0 A0AB56IDB0 PTHR45832:SF21 SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE Ras Pathway#P04393>PAK#P04553;Angiogenesis#P00005>PAK#P00249;T cell activation#P00053>PAK#P01319;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PAK#P00837;Cytoskeletal regulation by Rho GTPase#P00016>PAK#P00517 HUMAN|HGNC=5959|UniProtKB=O95163 O95163 ELP1 PTHR12747:SF0 ELONGATOR COMPLEX PROTEIN 1 ELONGATOR COMPLEX PROTEIN 1 RNA binding#GO:0003723;tRNA binding#GO:0000049;binding#GO:0005488;nucleic acid binding#GO:0003676 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;tRNA wobble uridine modification#GO:0002098;tRNA wobble base modification#GO:0002097;tRNA modification#GO:0006400;RNA biosynthetic process#GO:0032774;RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033 cytoplasm#GO:0005737;elongator holoenzyme complex#GO:0033588;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytosol#GO:0005829;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494 general transcription factor#PC00259 PDGF signaling pathway#P00047>Ikk#P01146 HUMAN|HGNC=25945|UniProtKB=Q9NXU5 Q9NXU5 ARL15 PTHR46693:SF1 ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 15 ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 15 HUMAN|HGNC=29488|UniProtKB=Q9H3K6 Q9H3K6 BOLA2 PTHR12735:SF42 BOLA-LIKE PROTEIN-RELATED BOLA-LIKE PROTEIN 2 small molecule binding#GO:0036094;binding#GO:0005488;iron-sulfur cluster binding#GO:0051536 intracellular iron ion homeostasis#GO:0006879;homeostatic process#GO:0042592;monoatomic ion homeostasis#GO:0050801;intracellular monoatomic ion homeostasis#GO:0006873;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;chemical homeostasis#GO:0048878;inorganic ion homeostasis#GO:0098771;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cytosol#GO:0005829;nucleus#GO:0005634 HUMAN|HGNC=19580|UniProtKB=Q9H2C5 Q9H2C5 OR52A5 PTHR26450:SF48 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 52A5 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=2665|UniProtKB=P08174 P08174 CD55 PTHR19325:SF317 COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING COMPLEMENT DECAY-ACCELERATING FACTOR defense/immunity protein#PC00090;complement component#PC00078 HUMAN|HGNC=20509|UniProtKB=Q6PJT7 Q6PJT7 ZC3H14 PTHR14738:SF29 ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14 ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14 single-stranded RNA binding#GO:0003727;RNA binding#GO:0003723;poly(A) binding#GO:0008143;binding#GO:0005488;nucleic acid binding#GO:0003676 biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of mRNA metabolic process#GO:1903311;post-transcriptional regulation of gene expression#GO:0010608;regulation of mRNA stability#GO:0043488;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of mRNA catabolic process#GO:0061013;regulation of biological quality#GO:0065008;regulation of RNA metabolic process#GO:0051252;regulation of RNA stability#GO:0043487 nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=40021|UniProtKB=Q8NCS4 Q8NCS4 TMEM35B PTHR13163:SF2 SPINAL CORD EXPRESSION PROTEIN 4 TRANSMEMBRANE PROTEIN 35B chaperone-mediated protein complex assembly#GO:0051131;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;regulation of localization#GO:0032879;regulation of protein localization#GO:0032880;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;regulation of biological process#GO:0050789;positive regulation of biological process#GO:0048518;cellular component assembly#GO:0022607;biological regulation#GO:0065007 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=18794|UniProtKB=Q75N90 Q75N90 FBN3 PTHR24039:SF0 FIBRILLIN-RELATED FIBRILLIN-3 hormone activity#GO:0005179;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018 chemical homeostasis#GO:0048878;monosaccharide metabolic process#GO:0005996;metabolic process#GO:0008152;glucose homeostasis#GO:0042593;glucose metabolic process#GO:0006006;carbohydrate homeostasis#GO:0033500;cellular process#GO:0009987;hexose metabolic process#GO:0019318;primary metabolic process#GO:0044238;homeostatic process#GO:0042592;carbohydrate metabolic process#GO:0005975;small molecule metabolic process#GO:0044281 extracellular matrix structural protein#PC00103 HUMAN|HGNC=4203|UniProtKB=Q02742 Q02742 GCNT1 PTHR19297:SF96 GLYCOSYLTRANSFERASE 14 FAMILY MEMBER BETA-1,3-GALACTOSYL-O-GLYCOSYL-GLYCOPROTEIN BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758;catalytic activity, acting on a protein#GO:0140096;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;acetylglucosaminyltransferase activity#GO:0008375 glycosyltransferase#PC00111 HUMAN|HGNC=23458|UniProtKB=Q86XJ0 Q86XJ0 CALHM3 PTHR32261:SF7 CALCIUM HOMEOSTASIS MODULATOR PROTEIN CALCIUM HOMEOSTASIS MODULATOR PROTEIN 3 monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 voltage-gated ion channel#PC00241 HUMAN|HGNC=6016|UniProtKB=P05113 P05113 IL5 PTHR48491:SF1 INTERLEUKIN-5 INTERLEUKIN-5 signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;cytokine activity#GO:0005125;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677 cell surface receptor signaling pathway#GO:0007166;cytokine-mediated signaling pathway#GO:0019221;response to peptide#GO:1901652;cell communication#GO:0007154;cellular response to cytokine stimulus#GO:0071345;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;biological regulation#GO:0065007;signaling#GO:0023052;response to chemical#GO:0042221;response to stimulus#GO:0050896;response to cytokine#GO:0034097;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 Interleukin signaling pathway#P00036>Interleukin#P00970;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>IL2#P00870 HUMAN|HGNC=4579|UniProtKB=P39086 P39086 GRIK1 PTHR18966:SF36 IONOTROPIC GLUTAMATE RECEPTOR GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 1 amino acid transmembrane transporter activity#GO:0015171;neurotransmitter receptor activity#GO:0030594;transporter activity#GO:0005215;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;gated channel activity#GO:0022836;monoatomic cation transmembrane transporter activity#GO:0008324;glutamate receptor activity#GO:0008066;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;sodium channel activity#GO:0005272;ligand-gated monoatomic cation channel activity#GO:0099094;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;dicarboxylic acid transmembrane transporter activity#GO:0005310;monoatomic cation channel activity#GO:0005261;sodium ion transmembrane transporter activity#GO:0015081;carboxylic acid transmembrane transporter activity#GO:0046943;potassium channel activity#GO:0005267;ligand-gated monoatomic ion channel activity#GO:0015276;potassium ion transmembrane transporter activity#GO:0015079;molecular transducer activity#GO:0060089;channel activity#GO:0015267 signaling#GO:0023052;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;cell communication#GO:0007154;regulation of signaling#GO:0023051;trans-synaptic signaling#GO:0099537;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;synaptic transmission, glutamatergic#GO:0035249;regulation of trans-synaptic signaling#GO:0099177;cellular process#GO:0009987;synaptic signaling#GO:0099536 postsynaptic density membrane#GO:0098839;sodium channel complex#GO:0034706;transmembrane transporter complex#GO:1902495;postsynaptic density#GO:0014069;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;synapse#GO:0045202;cellular anatomical structure#GO:0110165;asymmetric synapse#GO:0032279;organelle#GO:0043226;plasma membrane protein complex#GO:0098797;postsynapse#GO:0098794;membrane protein complex#GO:0098796;transporter complex#GO:1990351;cell junction#GO:0030054;signaling receptor complex#GO:0043235;synaptic membrane#GO:0097060;cation channel complex#GO:0034703;presynaptic membrane#GO:0042734;plasma membrane#GO:0005886;neuron to neuron synapse#GO:0098984;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;cell periphery#GO:0071944;presynapse#GO:0098793;membrane#GO:0016020 transmembrane signal receptor#PC00197 Ionotropic glutamate receptor pathway#P00037>A/K#P01025;Metabotropic glutamate receptor group III pathway#P00039>A/K#P01046;Huntington disease#P00029>Kainate receptor#P00796;Metabotropic glutamate receptor group I pathway#P00041>GluR5#P01054;Ionotropic glutamate receptor pathway#P00037>KA1#P01004;Ionotropic glutamate receptor pathway#P00037>KA#P01026 HUMAN|HGNC=21298|UniProtKB=Q86V21 Q86V21 AACS PTHR42921:SF5 ACETOACETYL-COA SYNTHETASE ACETOACETYL-COA SYNTHETASE ligase activity#GO:0016874;catalytic activity#GO:0003824;ligase activity, forming carbon-sulfur bonds#GO:0016877 biological regulation#GO:0065007;positive regulation of transport#GO:0051050;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of secretion by cell#GO:1903532;regulation of insulin secretion#GO:0050796;regulation of transport#GO:0051049;regulation of localization#GO:0032879;positive regulation of protein secretion#GO:0050714;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of protein transport#GO:0051223;regulation of hormone levels#GO:0010817;regulation of protein secretion#GO:0050708;regulation of biological process#GO:0050789;regulation of secretion by cell#GO:1903530;regulation of biological quality#GO:0065008;regulation of establishment of protein localization#GO:0070201;regulation of protein localization#GO:0032880;positive regulation of signaling#GO:0023056;regulation of secretion#GO:0051046;regulation of hormone secretion#GO:0046883;regulation of signaling#GO:0023051;positive regulation of secretion#GO:0051047;positive regulation of hormone secretion#GO:0046887 ligase#PC00142;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=17925|UniProtKB=Q9NZI6 Q9NZI6 TFCP2L1 PTHR11037:SF18 TRANSCRIPTION FACTOR CP2 TRANSCRIPTION FACTOR CP2-LIKE PROTEIN 1 sequence-specific double-stranded DNA binding#GO:1990837;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulator activity#GO:0140110;DNA-binding transcription activator activity#GO:0001216;transcription regulatory region nucleic acid binding#GO:0001067 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA-binding transcription factor#PC00218 HUMAN|HGNC=16704|UniProtKB=Q9P2U7 Q9P2U7 SLC17A7 PTHR11662:SF29 SOLUTE CARRIER FAMILY 17 VESICULAR GLUTAMATE TRANSPORTER 1 carboxylic acid transmembrane transporter activity#GO:0046943;amino acid transmembrane transporter activity#GO:0015171;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;dicarboxylic acid transmembrane transporter activity#GO:0005310;L-glutamate transmembrane transporter activity#GO:0005313;L-amino acid transmembrane transporter activity#GO:0015179;acidic amino acid transmembrane transporter activity#GO:0015172 signaling#GO:0023052;anterograde trans-synaptic signaling#GO:0098916;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;regulation of biological quality#GO:0065008;localization#GO:0051179;cell communication#GO:0007154;regulation of synapse structure or activity#GO:0050803;cellular localization#GO:0051641;trans-synaptic signaling#GO:0099537;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;synaptic transmission, glutamatergic#GO:0035249;neurotransmitter transport#GO:0006836;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;synaptic signaling#GO:0099536;vesicle-mediated transport in synapse#GO:0099003;establishment of localization#GO:0051234;synaptic vesicle cycle#GO:0099504;transport#GO:0006810 intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;synaptic vesicle#GO:0008021;synaptic vesicle membrane#GO:0030672;vesicle#GO:0031982;cell junction#GO:0030054;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;endomembrane system#GO:0012505;transport vesicle membrane#GO:0030658;cytoplasmic vesicle membrane#GO:0030659;transport vesicle#GO:0030133;cytoplasm#GO:0005737;secretory vesicle#GO:0099503;membrane#GO:0016020;vesicle membrane#GO:0012506;presynapse#GO:0098793 secondary carrier transporter#PC00258 Metabotropic glutamate receptor group III pathway#P00039>Vglut#P01038 HUMAN|HGNC=2409|UniProtKB=P07316 P07316 CRYGB PTHR11818:SF101 BETA/GAMMA CRYSTALLIN GAMMA-CRYSTALLIN B structural molecule activity#GO:0005198 sensory system development#GO:0048880;multicellular organismal process#GO:0032501;lens development in camera-type eye#GO:0002088;developmental process#GO:0032502;sensory organ development#GO:0007423;system process#GO:0003008;multicellular organism development#GO:0007275;animal organ development#GO:0048513;sensory perception of light stimulus#GO:0050953;visual system development#GO:0150063;visual perception#GO:0007601;sensory perception#GO:0007600;nervous system process#GO:0050877;camera-type eye development#GO:0043010;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;eye development#GO:0001654;anatomical structure development#GO:0048856 structural protein#PC00211 HUMAN|HGNC=26005|UniProtKB=Q8IWV1 Q8IWV1 LAX1 PTHR24091:SF0 LYMPHOCYTE TRANSMEMBRANE ADAPTER 1 LYMPHOCYTE TRANSMEMBRANE ADAPTER 1 immune response#GO:0006955;positive regulation of response to stimulus#GO:0048584;negative regulation of cell adhesion#GO:0007162;regulation of cell adhesion#GO:0030155;multicellular organismal process#GO:0032501;immune response-regulating cell surface receptor signaling pathway#GO:0002768;negative regulation of immune system process#GO:0002683;biological regulation#GO:0065007;regulation of leukocyte cell-cell adhesion#GO:1903037;negative regulation of cellular process#GO:0048523;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;negative regulation of cell activation#GO:0050866;negative regulation of multicellular organismal process#GO:0051241;leukocyte activation#GO:0045321;cellular response to stimulus#GO:0051716;regulation of immune system process#GO:0002682;regulation of cell-cell adhesion#GO:0022407;regulation of cellular process#GO:0050794;negative regulation of leukocyte cell-cell adhesion#GO:1903038;immune response-activating cell surface receptor signaling pathway#GO:0002429;negative regulation of T cell activation#GO:0050868;regulation of immune response#GO:0050776;cell activation#GO:0001775;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;positive regulation of immune system process#GO:0002684;activation of immune response#GO:0002253;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;negative regulation of cell-cell adhesion#GO:0022408;lymphocyte activation#GO:0046649;antigen receptor-mediated signaling pathway#GO:0050851;regulation of T cell activation#GO:0050863;negative regulation of leukocyte activation#GO:0002695;regulation of multicellular organismal process#GO:0051239;negative regulation of lymphocyte activation#GO:0051250;cell surface receptor signaling pathway#GO:0007166;immune response-activating signaling pathway#GO:0002757;regulation of leukocyte activation#GO:0002694;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cell activation#GO:0050865;immune response-regulating signaling pathway#GO:0002764;response to stimulus#GO:0050896;signaling#GO:0023052;regulation of lymphocyte activation#GO:0051249;immune system process#GO:0002376 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 defense/immunity protein#PC00090 HUMAN|HGNC=28981|UniProtKB=Q5TAX3 Q5TAX3 TUT4 PTHR12271:SF49 POLY A POLYMERASE CID PAP -RELATED TERMINAL URIDYLYLTRANSFERASE 4 transferase activity, transferring phosphorus-containing groups#GO:0016772;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on RNA#GO:0140098 macromolecule metabolic process#GO:0043170;positive regulation of catabolic process#GO:0009896;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;regulation of primary metabolic process#GO:0080090;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;nucleic acid catabolic process#GO:0141188;regulation of RNA metabolic process#GO:0051252;regulation of RNA stability#GO:0043487;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;positive regulation of mRNA catabolic process#GO:0061014;regulation of mRNA metabolic process#GO:1903311;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;positive regulation of mRNA metabolic process#GO:1903313;mRNA destabilization#GO:0061157;positive regulation of macromolecule metabolic process#GO:0010604;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;RNA destabilization#GO:0050779;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of metabolic process#GO:0009893;RNA metabolic process#GO:0016070;regulation of biological quality#GO:0065008;RNA catabolic process#GO:0006401;modification-dependent macromolecule catabolic process#GO:0043632;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;regulation of mRNA stability#GO:0043488;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789 nucleotidyltransferase#PC00174 HUMAN|HGNC=48661|UniProtKB=E5RQL4 E5RQL4 FTCDNL1 PTHR12234:SF1 FORMIMINOTRANSFERASE-CYCLODEAMINASE FORMIMINOTRANSFERASE N-TERMINAL SUBDOMAIN-CONTAINING PROTEIN catalytic activity#GO:0003824;transferase activity#GO:0016740 HUMAN|HGNC=4090|UniProtKB=P24046 P24046 GABRR1 PTHR18945:SF30 NEUROTRANSMITTER GATED ION CHANNEL GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT RHO-1 ligand-gated monoatomic ion channel activity#GO:0015276;molecular transducer activity#GO:0060089;monoatomic anion channel activity#GO:0005253;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;chloride transmembrane transporter activity#GO:0015108;ligand-gated channel activity#GO:0022834;transmembrane transporter activity#GO:0022857;gated channel activity#GO:0022836;transmembrane signaling receptor activity#GO:0004888;neurotransmitter receptor activity#GO:0030594;chloride channel activity#GO:0005254;transporter activity#GO:0005215;monoatomic anion transmembrane transporter activity#GO:0008509;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;signaling receptor activity#GO:0038023 synaptic signaling#GO:0099536;cellular process#GO:0009987;monoatomic anion transmembrane transport#GO:0098656;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;monoatomic ion transmembrane transport#GO:0034220;chloride transport#GO:0006821;transport#GO:0006810;establishment of localization#GO:0051234;monoatomic anion transport#GO:0006820;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;anterograde trans-synaptic signaling#GO:0098916;signaling#GO:0023052;trans-synaptic signaling#GO:0099537;chloride transmembrane transport#GO:1902476;localization#GO:0051179;cell communication#GO:0007154;transmembrane transport#GO:0055085;inorganic anion transport#GO:0015698;monoatomic ion transport#GO:0006811 GABA-ergic synapse#GO:0098982;plasma membrane#GO:0005886;synapse#GO:0045202;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;cell junction#GO:0030054;signaling receptor complex#GO:0043235 ligand-gated ion channel#PC00141 HUMAN|HGNC=22431|UniProtKB=Q5HYL7 Q5HYL7 TMEM196 PTHR28681:SF1 TRANSMEMBRANE PROTEIN 196 TRANSMEMBRANE PROTEIN 196 HUMAN|HGNC=20295|UniProtKB=O94991 O94991 SLITRK5 PTHR45773:SF5 SLIT AND NTRK-LIKE PROTEIN 4-RELATED SLIT AND NTRK-LIKE PROTEIN 5 regulation of cell junction assembly#GO:1901888;regulation of nervous system development#GO:0051960;regulation of synapse structure or activity#GO:0050803;anatomical structure development#GO:0048856;system development#GO:0048731;regulation of cellular process#GO:0050794;regulation of developmental process#GO:0050793;positive regulation of developmental process#GO:0051094;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;cellular developmental process#GO:0048869;positive regulation of synapse assembly#GO:0051965;neurogenesis#GO:0022008;axon development#GO:0061564;positive regulation of cellular process#GO:0048522;regulation of synapse assembly#GO:0051963;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;animal gross anatomical part developmental process#GO:0160108;positive regulation of cellular component organization#GO:0051130;generation of neurons#GO:0048699;regulation of synapse organization#GO:0050807;neuron development#GO:0048666;axonogenesis#GO:0007409;regulation of biological quality#GO:0065008;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;positive regulation of multicellular organismal process#GO:0051240;regulation of multicellular organismal development#GO:2000026;cell projection organization#GO:0030030;regulation of cellular component organization#GO:0051128;positive regulation of nervous system development#GO:0051962;cell differentiation#GO:0030154;cell morphogenesis#GO:0000902;cell development#GO:0048468;regulation of cellular component biogenesis#GO:0044087;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cell projection morphogenesis#GO:0048858;neuron projection development#GO:0031175;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of cellular component biogenesis#GO:0044089;regulation of multicellular organismal process#GO:0051239;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667 transmembrane signal receptor#PC00197 HUMAN|HGNC=4431|UniProtKB=O14653 O14653 GOSR2 PTHR21230:SF99 VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED GOLGI SNAP RECEPTOR COMPLEX MEMBER 2 SNAP receptor activity#GO:0005484;protein binding#GO:0005515;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;SNARE binding#GO:0000149;binding#GO:0005488 localization#GO:0051179;intra-Golgi vesicle-mediated transport#GO:0006891;cellular component organization#GO:0016043;vesicle fusion#GO:0006906;Golgi vesicle transport#GO:0048193;transport#GO:0006810;vesicle organization#GO:0016050;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;membrane fusion#GO:0061025;organelle organization#GO:0006996;organelle membrane fusion#GO:0090174;membrane organization#GO:0061024;vesicle-mediated transport#GO:0016192;organelle fusion#GO:0048284 organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;coated vesicle#GO:0030135;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;COPII-coated ER to Golgi transport vesicle#GO:0030134;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;coated vesicle membrane#GO:0030662;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;SNARE complex#GO:0031201;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;ER to Golgi transport vesicle membrane#GO:0012507;endoplasmic reticulum#GO:0005783;Golgi apparatus#GO:0005794;endoplasmic reticulum membrane#GO:0005789;cytoplasm#GO:0005737;transport vesicle#GO:0030133;transport vesicle membrane#GO:0030658;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;vesicle membrane#GO:0012506;membrane#GO:0016020 SNARE protein#PC00034;membrane traffic protein#PC00150 HUMAN|HGNC=6723|UniProtKB=Q9NQ29 Q9NQ29 LUC7L PTHR12375:SF31 RNA-BINDING PROTEIN LUC7-RELATED RNA-BINDING PROTEIN LUC7-LIKE 1-RELATED RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676 protein-containing complex organization#GO:0043933;protein-RNA complex organization#GO:0071826;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;mRNA splice site recognition#GO:0006376;gene expression#GO:0010467;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;mRNA processing#GO:0006397;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;protein-RNA complex assembly#GO:0022618;spliceosomal complex assembly#GO:0000245;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;protein-containing complex assembly#GO:0065003;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;nucleic acid metabolic process#GO:0090304 ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;spliceosomal snRNP complex#GO:0097525;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;spliceosomal complex#GO:0005681;organelle#GO:0043226;cellular anatomical structure#GO:0110165;U2-type prespliceosome#GO:0071004;intracellular membrane-bounded organelle#GO:0043231;U2-type spliceosomal complex#GO:0005684;nuclear protein-containing complex#GO:0140513;Sm-like protein family complex#GO:0120114;small nuclear ribonucleoprotein complex#GO:0030532;nucleus#GO:0005634;U1 snRNP#GO:0005685;protein-containing complex#GO:0032991 HUMAN|HGNC=16682|UniProtKB=Q86T24 Q86T24 ZBTB33 PTHR24399:SF24 ZINC FINGER AND BTB DOMAIN-CONTAINING TRANSCRIPTIONAL REGULATOR KAISO transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription repressor activity#GO:0001217;transcription regulator activity#GO:0140110;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;regulation of multicellular organismal process#GO:0051239;regulation of primary metabolic process#GO:0080090;regulation of cytokine production#GO:0001817;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=4082|UniProtKB=P47870 P47870 GABRB2 PTHR18945:SF916 NEUROTRANSMITTER GATED ION CHANNEL GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-2 ligand-gated monoatomic ion channel activity#GO:0015276;molecular transducer activity#GO:0060089;monoatomic anion channel activity#GO:0005253;channel activity#GO:0015267;ligand-gated channel activity#GO:0022834;chloride transmembrane transporter activity#GO:0015108;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transmembrane signaling receptor activity#GO:0004888;gated channel activity#GO:0022836;chloride channel activity#GO:0005254;neurotransmitter receptor activity#GO:0030594;monoatomic anion transmembrane transporter activity#GO:0008509;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion channel activity#GO:0005216;signaling receptor activity#GO:0038023 synaptic signaling#GO:0099536;cellular process#GO:0009987;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;chloride transport#GO:0006821;transport#GO:0006810;establishment of localization#GO:0051234;chemical synaptic transmission#GO:0007268;monoatomic anion transport#GO:0006820;regulation of biological process#GO:0050789;anterograde trans-synaptic signaling#GO:0098916;signaling#GO:0023052;trans-synaptic signaling#GO:0099537;transmembrane transport#GO:0055085;cell communication#GO:0007154;chloride transmembrane transport#GO:1902476;localization#GO:0051179;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;GABA-ergic synapse#GO:0098982;synapse#GO:0045202;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;signaling receptor complex#GO:0043235;cell junction#GO:0030054 ligand-gated ion channel#PC00141 HUMAN|HGNC=3071|UniProtKB=Q16690 Q16690 DUSP5 PTHR10159:SF40 DUAL SPECIFICITY PROTEIN PHOSPHATASE DUAL SPECIFICITY PROTEIN PHOSPHATASE 5 hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725;phosphoprotein phosphatase activity#GO:0004721;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;catalytic activity#GO:0003824;protein tyrosine/serine/threonine phosphatase activity#GO:0008138;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791 negative regulation of response to stimulus#GO:0048585;multicellular organismal process#GO:0032501;tissue development#GO:0009888;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;developmental process#GO:0032502;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;cellular response to stimulus#GO:0051716;negative regulation of MAPK cascade#GO:0043409;anatomical structure development#GO:0048856;cell communication#GO:0007154;endoderm formation#GO:0001706;embryo development#GO:0009790;negative regulation of signal transduction#GO:0009968;cellular process#GO:0009987;signal transduction#GO:0007165;embryonic morphogenesis#GO:0048598;multicellular organism development#GO:0007275;anatomical structure formation involved in morphogenesis#GO:0048646;endoderm development#GO:0007492;regulation of MAPK cascade#GO:0043408;response to stimulus#GO:0050896;signaling#GO:0023052;gastrulation#GO:0007369;negative regulation of biological process#GO:0048519;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;regulation of intracellular signal transduction#GO:1902531;animal gross anatomical part developmental process#GO:0160108;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;formation of primary germ layer#GO:0001704 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 protein phosphatase#PC00195 Oxidative stress response#P00046>MKP5#P01131 HUMAN|HGNC=28046|UniProtKB=Q9UDW3 Q9UDW3 ZMAT5 PTHR16465:SF0 NUCLEASE-RELATED ZINC FINGER MATRIN-TYPE PROTEIN 5 nucleus#GO:0005634;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;U12-type spliceosomal complex#GO:0005689 HUMAN|HGNC=24493|UniProtKB=Q9BV44 Q9BV44 THUMPD3 PTHR14911:SF13 THUMP DOMAIN-CONTAINING TRNA (GUANINE(6)-N(2))-METHYLTRANSFERASE THUMP3 S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;tRNA (guanine) methyltransferase activity#GO:0016423;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on RNA#GO:0140098;RNA methyltransferase activity#GO:0008173;tRNA methyltransferase activity#GO:0008175 macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;macromolecule biosynthetic process#GO:0009059;tRNA methylation#GO:0030488;cellular process#GO:0009987;methylation#GO:0032259;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;RNA methylation#GO:0001510;RNA modification#GO:0009451;macromolecule methylation#GO:0043414;nucleic acid biosynthetic process#GO:0141187;tRNA modification#GO:0006400;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 RNA methyltransferase#PC00033;RNA metabolism protein#PC00031 HUMAN|HGNC=25858|UniProtKB=Q8TCF1 Q8TCF1 ZFAND1 PTHR14677:SF37 ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED AN1-TYPE ZINC FINGER PROTEIN 1 protein-containing complex disassembly#GO:0032984;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;cellular component disassembly#GO:0022411;protein-RNA complex organization#GO:0071826;cellular component organization or biogenesis#GO:0071840;organelle disassembly#GO:1903008 cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;cytoplasmic stress granule#GO:0010494;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031 HUMAN|HGNC=23177|UniProtKB=Q14145 Q14145 KEAP1 PTHR24412:SF162 KELCH PROTEIN KELCH-LIKE ECH-ASSOCIATED PROTEIN 1 ubiquitin-like ligase-substrate adaptor activity#GO:1990756;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;enzyme-substrate adaptor activity#GO:0140767 catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163 catalytic complex#GO:1902494;transferase complex#GO:1990234;Cul3-RING ubiquitin ligase complex#GO:0031463;ubiquitin ligase complex#GO:0000151;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cullin-RING ubiquitin ligase complex#GO:0031461;cytoplasm#GO:0005737 scaffold/adaptor protein#PC00226 HUMAN|HGNC=25695|UniProtKB=Q9HA77 Q9HA77 CARS2 PTHR10890:SF27 CYSTEINYL-TRNA SYNTHETASE CYSTEINE--TRNA LIGASE, MITOCHONDRIAL-RELATED catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;ligase activity#GO:0016874 RNA metabolic process#GO:0016070;protein metabolic process#GO:0019538;translation#GO:0006412;protein biosynthetic process#GO:0160307;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;amino acid activation#GO:0043038;macromolecule metabolic process#GO:0043170;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;gene expression#GO:0010467;amino acid metabolic process#GO:0006520;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;tRNA aminoacylation#GO:0043039;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;tRNA aminoacylation for protein translation#GO:0006418 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739 aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 HUMAN|HGNC=32261|UniProtKB=P0C7W8 P0C7W8 FAM90A13 PTHR16035:SF14 PROTEIN FAM90A1 PROTEIN FAM90A10-RELATED HUMAN|HGNC=2444|UniProtKB=P41240 P41240 CSK PTHR24418:SF472 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE CSK catalytic activity, acting on a protein#GO:0140096;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;non-membrane spanning protein tyrosine kinase activity#GO:0004715 regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;regulation of immune response#GO:0050776;cell-cell junction organization#GO:0045216;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;adherens junction organization#GO:0034332;regulation of cell communication#GO:0010646;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;cell junction organization#GO:0034330;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 non-receptor tyrosine protein kinase#PC00168 CCKR signaling map#P06959>CSK#P07072;T cell activation#P00053>Csk#P01304;Parkinson disease#P00049>Src kinase#P01230;Integrin signalling pathway#P00034>Csk#P00913 HUMAN|HGNC=18517|UniProtKB=Q6EMK4 Q6EMK4 VASN PTHR24373:SF261 SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN VASORIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=6330|UniProtKB=P43627 P43627 KIR2DL2 PTHR11738:SF168 MHC CLASS I NK CELL RECEPTOR IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN-RELATED transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;immune receptor activity#GO:0140375 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;immune response-regulating signaling pathway#GO:0002764;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;immune response-regulating cell surface receptor signaling pathway#GO:0002768;regulation of immune response#GO:0050776;cell surface receptor signaling pathway#GO:0007166;regulation of response to stimulus#GO:0048583;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=33995|UniProtKB=A0A0B4J2A2 A0A0B4J2A2 PPIAL4C PTHR11071:SF466 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A-LIKE 4C-RELATED intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 chaperone#PC00072 HUMAN|HGNC=9851|UniProtKB=O60518 O60518 RANBP6 PTHR10527:SF16 IMPORTIN BETA RAN-BINDING PROTEIN 6 nucleocytoplasmic carrier activity#GO:0140142;molecular carrier activity#GO:0140104 cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;protein localization to nucleus#GO:0034504;macromolecule localization#GO:0033036;import into nucleus#GO:0051170;transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;protein localization to organelle#GO:0033365;nucleocytoplasmic transport#GO:0006913;protein import into nucleus#GO:0006606;protein transport#GO:0015031;nuclear transport#GO:0051169;cellular localization#GO:0051641;localization#GO:0051179 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 transporter#PC00227 HUMAN|HGNC=6371|UniProtKB=P03952 P03952 KLKB1 PTHR24253:SF64 TRANSMEMBRANE PROTEASE SERINE PLASMA KALLIKREIN catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824;serine-type peptidase activity#GO:0008236 biosynthetic process#GO:0009058;biological regulation#GO:0065007;negative regulation of response to stimulus#GO:0048585;regulation of coagulation#GO:0050818;macromolecule biosynthetic process#GO:0009059;regulation of hemostasis#GO:1900046;protein processing#GO:0016485;negative regulation of wound healing#GO:0061045;plasminogen activation#GO:0031639;macromolecule metabolic process#GO:0043170;regulation of response to stimulus#GO:0048583;regulation of response to stress#GO:0080134;negative regulation of blood coagulation#GO:0030195;primary metabolic process#GO:0044238;negative regulation of multicellular organismal process#GO:0051241;protein metabolic process#GO:0019538;regulation of multicellular organismal process#GO:0051239;negative regulation of response to external stimulus#GO:0032102;regulation of response to external stimulus#GO:0032101;protein maturation#GO:0051604;gene expression#GO:0010467;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;regulation of response to wounding#GO:1903034;negative regulation of response to wounding#GO:1903035;metabolic process#GO:0008152;regulation of wound healing#GO:0061041;regulation of body fluid levels#GO:0050878;regulation of blood coagulation#GO:0030193;zymogen activation#GO:0031638;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of biological quality#GO:0065008;negative regulation of coagulation#GO:0050819;negative regulation of hemostasis#GO:1900047;proteolysis#GO:0006508 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease#PC00190;serine protease#PC00203;protein modifying enzyme#PC00260 Blood coagulation#P00011>Prekallikrein#P00439;Blood coagulation#P00011>Kallikrein#P00437 HUMAN|HGNC=24153|UniProtKB=Q8N111 Q8N111 CEND1 PTHR36683:SF1 CELL CYCLE EXIT AND NEURONAL DIFFERENTIATION PROTEIN 1 CELL CYCLE EXIT AND NEURONAL DIFFERENTIATION PROTEIN 1 animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;anatomical structure development#GO:0048856;system development#GO:0048731;anatomical structure maturation#GO:0071695;anatomical structure morphogenesis#GO:0009653;cell differentiation#GO:0030154;central nervous system development#GO:0007417;cell motility#GO:0048870;neuron differentiation#GO:0030182;developmental process#GO:0032502;central nervous system neuron differentiation#GO:0021953;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;animal organ development#GO:0048513;neurogenesis#GO:0022008;anatomical structure formation involved in morphogenesis#GO:0048646;cellular process#GO:0009987;brain development#GO:0007420;developmental maturation#GO:0021700;cell migration#GO:0016477;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;head development#GO:0060322 HUMAN|HGNC=23487|UniProtKB=Q9BXS1 Q9BXS1 IDI2 PTHR10885:SF1 ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE 2 catalytic activity#GO:0003824;intramolecular oxidoreductase activity#GO:0016860;isomerase activity#GO:0016853 phospholipid metabolic process#GO:0006644;biosynthetic process#GO:0009058;phospholipid biosynthetic process#GO:0008654;lipid biosynthetic process#GO:0008610;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;isoprenoid metabolic process#GO:0006720;organophosphate biosynthetic process#GO:0090407;lipid metabolic process#GO:0006629;isoprenoid biosynthetic process#GO:0008299;metabolic process#GO:0008152 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;microbody#GO:0042579;peroxisome#GO:0005777;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 isomerase#PC00135 Cholesterol biosynthesis#P00014>Isopentenyl diphosphate delta-isomerase#P00495 HUMAN|HGNC=7981|UniProtKB=P43354 P43354 NR4A2 PTHR24085:SF0 NUCLEAR HORMONE RECEPTOR NUCLEAR RECEPTOR SUBFAMILY 4 GROUP A MEMBER 2 RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific double-stranded DNA binding#GO:1990837;transcription factor binding#GO:0008134;DNA-binding transcription factor binding#GO:0140297;transcription regulatory region nucleic acid binding#GO:0001067;RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629;protein binding#GO:0005515;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;sequence-specific DNA binding#GO:0043565;nuclear receptor binding#GO:0016922 cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;cellular response to peptide hormone stimulus#GO:0071375;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;response to nitrogen compound#GO:1901698;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;multicellular organismal process#GO:0032501;cellular response to nitrogen compound#GO:1901699;regulation of nucleobase-containing compound metabolic process#GO:0019219;response to peptide hormone#GO:0043434;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;central nervous system neuron differentiation#GO:0021953;developmental process#GO:0032502;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;cellular response to hormone stimulus#GO:0032870;central nervous system development#GO:0007417;cellular response to endogenous stimulus#GO:0071495;cell differentiation#GO:0030154;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;animal gross anatomical part developmental process#GO:0160108;cellular response to chemical stimulus#GO:0070887;generation of neurons#GO:0048699;response to oxygen-containing compound#GO:1901700;response to hormone#GO:0009725;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;response to chemical#GO:0042221;nervous system development#GO:0007399;neuron differentiation#GO:0030182;multicellular organism development#GO:0007275 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227 C4 zinc finger nuclear receptor#PC00169;DNA-binding transcription factor#PC00218 HUMAN|HGNC=32962|UniProtKB=P0C7U3 P0C7U3 ZDHHC11B PTHR22883:SF22 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE ZDHHC11-RELATED catalytic activity, acting on a protein#GO:0140096;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;palmitoyltransferase activity#GO:0016409;acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824 immune system process#GO:0002376;localization within membrane#GO:0051668;localization#GO:0051179;response to virus#GO:0009615;cellular localization#GO:0051641;defense response to virus#GO:0051607;antiviral innate immune response#GO:0140374;response to stimulus#GO:0050896;protein targeting#GO:0006605;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;protein targeting to membrane#GO:0006612;establishment of localization#GO:0051234;innate immune response#GO:0045087;response to external stimulus#GO:0009605;defense response#GO:0006952;response to biotic stimulus#GO:0009607;establishment of protein localization to membrane#GO:0090150;response to stress#GO:0006950;immune response#GO:0006955;establishment of protein localization#GO:0045184;defense response to symbiont#GO:0140546;cellular process#GO:0009987;defense response to other organism#GO:0098542;response to other organism#GO:0051707 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 protein modifying enzyme#PC00260 HUMAN|HGNC=24715|UniProtKB=Q0IIM8 Q0IIM8 TBC1D8B PTHR22957:SF320 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN TBC1 DOMAIN FAMILY MEMBER 8B GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047 renal system process#GO:0003014;system process#GO:0003008;multicellular organismal process#GO:0032501 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HUMAN|HGNC=30649|UniProtKB=Q76M96 Q76M96 CCDC80 PTHR46792:SF2 COILED-COIL DOMAIN-CONTAINING PROTEIN 80 COILED-COIL DOMAIN-CONTAINING PROTEIN 80 extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;external encapsulating structure organization#GO:0045229;extracellular structure organization#GO:0043062;regulation of cell adhesion#GO:0030155;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of cell-substrate adhesion#GO:0010810;cellular component organization#GO:0016043;cellular process#GO:0009987;positive regulation of cell adhesion#GO:0045785;positive regulation of cell-substrate adhesion#GO:0010811;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;basement membrane#GO:0005604;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 HUMAN|HGNC=16634|UniProtKB=Q9Y291 Q9Y291 MRPS33 PTHR13362:SF2 MITOCHONDRIAL RIBOSOMAL PROTEIN S33 SMALL RIBOSOMAL SUBUNIT PROTEIN MS33 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 translational protein#PC00263;ribosomal protein#PC00202 HUMAN|HGNC=21876|UniProtKB=Q6NUQ1 Q6NUQ1 RINT1 PTHR13520:SF0 RAD50-INTERACTING PROTEIN 1 RINT-1 RAD50-INTERACTING PROTEIN 1 vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;localization#GO:0051179;Golgi vesicle transport#GO:0048193;transport#GO:0006810;cellular process#GO:0009987;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;vesicle tethering complex#GO:0099023;membrane-bounded organelle#GO:0043227;endoplasmic reticulum protein-containing complex#GO:0140534 HUMAN|HGNC=3972|UniProtKB=Q12841 Q12841 FSTL1 PTHR10913:SF13 FOLLISTATIN-RELATED FOLLISTATIN-RELATED PROTEIN 1 developmental process#GO:0032502;cellular process#GO:0009987;cell differentiation#GO:0030154;cellular developmental process#GO:0048869 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 Cadherin signaling pathway#P00012>Wnt#P00474;Wnt signaling pathway#P00057>Wnt#P01444;Alzheimer disease-presenilin pathway#P00004>Wnt#P00142 HUMAN|HGNC=28869|UniProtKB=Q7Z5V6 Q7Z5V6 SAXO4 PTHR34349:SF1 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 32 STABILIZER OF AXONEMAL MICROTUBULES 4 binding#GO:0005488;phosphatase binding#GO:0019902;enzyme binding#GO:0019899;protein binding#GO:0005515 phosphatase modulator#PC00184 HUMAN|HGNC=474|UniProtKB=P0DUB6 P0DUB6 AMY1A PTHR43447:SF50 ALPHA-AMYLASE ALPHA-AMYLASE 1A-RELATED extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 amylase#PC00048 HUMAN|HGNC=1266|UniProtKB=Q9Y426 Q9Y426 C2CD2 PTHR21119:SF7 C2 DOMAIN-CONTAINING PROTEIN C2 DOMAIN-CONTAINING PROTEIN 2 HUMAN|HGNC=12405|UniProtKB=P02766 P02766 TTR PTHR10395:SF12 URICASE AND TRANSTHYRETIN-RELATED TRANSTHYRETIN nucleobase-containing compound metabolic process#GO:0006139;small molecule metabolic process#GO:0044281;cellular process#GO:0009987;purine-containing compound metabolic process#GO:0072521;primary metabolic process#GO:0044238;nucleobase metabolic process#GO:0009112;nucleobase-containing small molecule metabolic process#GO:0055086;purine nucleobase metabolic process#GO:0006144;metabolic process#GO:0008152 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 hydrolase#PC00121 HUMAN|HGNC=26959|UniProtKB=A6NE52 A6NE52 WDR97 PTHR45532:SF1 WD REPEAT-CONTAINING PROTEIN 97 WD REPEAT-CONTAINING PROTEIN 97 HUMAN|HGNC=19255|UniProtKB=Q5JTB6 Q5JTB6 PLAC9 PTHR37355:SF1 PLACENTA-SPECIFIC PROTEIN 9 PLACENTA-SPECIFIC PROTEIN 9 HUMAN|HGNC=4538|UniProtKB=Q9BY21 Q9BY21 GPR87 PTHR24233:SF8 P2Y PURINOCEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR G PROTEIN-COUPLED RECEPTOR 87 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930 biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=25231|UniProtKB=Q9Y548 Q9Y548 YIPF1 PTHR12822:SF4 PROTEIN YIPF PROTEIN YIPF1 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=16051|UniProtKB=Q8TEW0 Q8TEW0 PARD3 PTHR16484:SF10 PARTITIONING DEFECTIVE 3 RELATED PARTITIONING DEFECTIVE 3 HOMOLOG ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;phosphatidylinositol binding#GO:0035091;binding#GO:0005488 cellular component organization#GO:0016043;establishment of cell polarity#GO:0030010;establishment or maintenance of apical/basal cell polarity#GO:0035088;establishment or maintenance of cell polarity#GO:0007163;establishment or maintenance of bipolar cell polarity#GO:0061245;cell adhesion#GO:0007155;microtubule cytoskeleton organization#GO:0000226;localization#GO:0051179;establishment or maintenance of epithelial cell apical/basal polarity#GO:0045197;organelle organization#GO:0006996;macromolecule localization#GO:0033036;cellular process#GO:0009987;cytoskeleton organization#GO:0007010;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;intracellular protein localization#GO:0008104 intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;adherens junction#GO:0005912;cell junction#GO:0030054;apical part of cell#GO:0045177;apical junction complex#GO:0043296;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;cell periphery#GO:0071944;cell cortex#GO:0005938;cell-cell junction#GO:0005911;membrane#GO:0016020;apical plasma membrane#GO:0016324 HUMAN|Gene=YI024_HUMAN|UniProtKB=Q5PR19 Q5PR19 PTHR15566:SF10 POM121-LIKE UPF0607 PROTEIN ENSP00000332738-RELATED HUMAN|HGNC=8912|UniProtKB=P35232 P35232 PHB1 PTHR23222:SF37 PROHIBITIN PROHIBITIN 1 cellular component organization or biogenesis#GO:0071840;mitochondrion organization#GO:0007005;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739 HUMAN|HGNC=17261|UniProtKB=Q9Y3A3 Q9Y3A3 MOB4 PTHR22599:SF56 MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB MOB-LIKE PROTEIN PHOCEIN cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 kinase activator#PC00138 HUMAN|HGNC=17877|UniProtKB=Q9HAN9 Q9HAN9 NMNAT1 PTHR12039:SF21 NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE NICOTINAMIDE_NICOTINIC ACID MONONUCLEOTIDE ADENYLYLTRANSFERASE 1 transferase activity, transferring phosphorus-containing groups#GO:0016772;adenylyltransferase activity#GO:0070566;catalytic activity#GO:0003824;transferase activity#GO:0016740;nucleotidyltransferase activity#GO:0016779 nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;NAD+ metabolic process#GO:0019674;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;nicotinamide nucleotide metabolic process#GO:0046496;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing small molecule metabolic process#GO:0055086;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;organophosphate biosynthetic process#GO:0090407;nucleotide metabolic process#GO:0009117;nucleotide biosynthetic process#GO:0009165;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;pyridine-containing compound metabolic process#GO:0072524 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 nucleotidyltransferase#PC00174;transferase#PC00220 HUMAN|HGNC=8062|UniProtKB=P49790 P49790 NUP153 PTHR23193:SF23 NUCLEAR PORE COMPLEX PROTEIN NUP NUCLEAR PORE COMPLEX PROTEIN NUP153 structural molecule activity#GO:0005198;structural constituent of nuclear pore#GO:0017056;nucleocytoplasmic carrier activity#GO:0140142;molecular carrier activity#GO:0140104 nitrogen compound transport#GO:0071705;protein localization to nucleus#GO:0034504;macromolecule localization#GO:0033036;import into nucleus#GO:0051170;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;intracellular protein transport#GO:0006886;transport#GO:0006810;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;intracellular protein localization#GO:0008104;protein localization to organelle#GO:0033365;RNA localization#GO:0006403;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;establishment of RNA localization#GO:0051236;nucleocytoplasmic transport#GO:0006913;cellular localization#GO:0051641;nucleic acid transport#GO:0050657;localization#GO:0051179;protein import into nucleus#GO:0006606;protein transport#GO:0015031;nuclear export#GO:0051168;nuclear transport#GO:0051169 protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;organelle envelope#GO:0031967;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;nuclear pore#GO:0005643;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 transporter#PC00227 HUMAN|HGNC=28157|UniProtKB=Q53EU6 Q53EU6 GPAT3 PTHR23063:SF10 PHOSPHOLIPID ACYLTRANSFERASE GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE 3 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 metabolite interconversion enzyme#PC00262;transferase#PC00220;acyltransferase#PC00042 HUMAN|HGNC=21764|UniProtKB=Q6ZN68 Q6ZN68 DPY19L2P2 PTHR31488:SF6 DPY-19-LIKE 1, LIKE (H. SAPIENS) C-MANNOSYLTRANSFERASE DPY19L2-RELATED mannosyltransferase activity#GO:0000030;glycosyltransferase activity#GO:0016757;hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;catalytic activity#GO:0003824 multicellular organismal reproductive process#GO:0048609;anatomical structure development#GO:0048856;spermatid development#GO:0007286;sexual reproduction#GO:0019953;spermatid differentiation#GO:0048515;cell development#GO:0048468;cellular process involved in reproduction in multicellular organism#GO:0022412;reproductive process#GO:0022414;gamete generation#GO:0007276;cell differentiation#GO:0030154;germ cell development#GO:0007281;developmental process involved in reproduction#GO:0003006;cellular developmental process#GO:0048869;spermatogenesis#GO:0007283;developmental process#GO:0032502;male gamete generation#GO:0048232;cellular process#GO:0009987 endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;nuclear membrane#GO:0031965;nuclear inner membrane#GO:0005637;organelle membrane#GO:0031090;organelle inner membrane#GO:0019866;nucleus#GO:0005634;membrane#GO:0016020;nuclear envelope#GO:0005635;cytoplasm#GO:0005737;endomembrane system#GO:0012505;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165 HUMAN|HGNC=30619|UniProtKB=Q2M3C7 Q2M3C7 SPHKAP PTHR10226:SF7 A KINASE ANCHOR PROTEIN A-KINASE ANCHOR PROTEIN SPHKAP binding#GO:0005488;protein kinase A binding#GO:0051018;protein binding#GO:0005515 mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HUMAN|HGNC=20878|UniProtKB=Q9Y2A4 Q9Y2A4 ZNF443 PTHR24379:SF68 KRAB AND ZINC FINGER DOMAIN-CONTAINING ZINC FINGER PROTEIN 443 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HUMAN|HGNC=21176|UniProtKB=Q9NWS8 Q9NWS8 RMND1 PTHR16255:SF1 REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG post-transcriptional regulation of gene expression#GO:0010608;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;regulation of macromolecule biosynthetic process#GO:0010556;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of protein metabolic process#GO:0051247;positive regulation of translation#GO:0045727;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 HUMAN|HGNC=13203|UniProtKB=Q9GZX7 Q9GZX7 AICDA PTHR13857:SF10 MRNA EDITING ENZYME SINGLE-STRANDED DNA CYTOSINE DEAMINASE nucleic acid binding#GO:0003676;binding#GO:0005488;hydrolase activity#GO:0016787;RNA binding#GO:0003723;catalytic activity#GO:0003824;deaminase activity#GO:0019239;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810 metabolic process#GO:0008152;DNA metabolic process#GO:0006259;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of macromolecule biosynthetic process#GO:0010558;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;cellular process#GO:0009987;RNA metabolic process#GO:0016070;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;base conversion or substitution editing#GO:0016553;RNA modification#GO:0009451;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;defense response to virus#GO:0051607;regulation of biological process#GO:0050789;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;response to external stimulus#GO:0009605;defense response#GO:0006952;negative regulation of cellular process#GO:0048523;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;response to other organism#GO:0051707;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;macromolecule modification#GO:0043412;response to virus#GO:0009615;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;response to external biotic stimulus#GO:0043207;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cytidine to uridine editing#GO:0016554 nucleus#GO:0005634;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;intracellular organelle#GO:0043229;P-body#GO:0000932;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 RNA processing factor#PC00147 HUMAN|HGNC=24748|UniProtKB=Q68D51 Q68D51 DENND2C PTHR15288:SF6 DENN DOMAIN-CONTAINING PROTEIN 2 DENN DOMAIN-CONTAINING PROTEIN 2C enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=9486|UniProtKB=P35030 P35030 PRSS3 PTHR24264:SF48 TRYPSIN-RELATED TRYPSIN-3 serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175 cellular process#GO:0009987;metabolic process#GO:0008152;proteolysis#GO:0006508;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 serine protease#PC00203;protease#PC00190 HUMAN|HGNC=4558|UniProtKB=P59796 P59796 GPX6 PTHR11592:SF15 GLUTATHIONE PEROXIDASE GLUTATHIONE PEROXIDASE 6 oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on peroxide as acceptor#GO:0016684;catalytic activity#GO:0003824;antioxidant activity#GO:0016209;peroxidase activity#GO:0004601 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stress#GO:0006950;response to stimulus#GO:0050896;response to chemical#GO:0042221;cellular response to oxidative stress#GO:0034599;cellular response to stress#GO:0033554;cellular response to chemical stimulus#GO:0070887;cellular response to chemical stress#GO:0062197;response to oxidative stress#GO:0006979 peroxidase#PC00180;oxidoreductase#PC00176 HUMAN|HGNC=16931|UniProtKB=Q9Y4L1 Q9Y4L1 HYOU1 PTHR45639:SF37 HSC70CB, ISOFORM G-RELATED HYPOXIA UP-REGULATED PROTEIN 1 enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function regulator activity#GO:0098772 biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of signal transduction#GO:0009968;negative regulation of apoptotic process#GO:0043066;negative regulation of response to stimulus#GO:0048585;negative regulation of programmed cell death#GO:0043069;regulation of apoptotic process#GO:0042981;regulation of response to stimulus#GO:0048583;negative regulation of intrinsic apoptotic signaling pathway#GO:2001243;regulation of response to stress#GO:0080134;negative regulation of cellular process#GO:0048523;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of intrinsic apoptotic signaling pathway#GO:2001242;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;regulation of cellular response to stress#GO:0080135;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of apoptotic signaling pathway#GO:2001234;regulation of apoptotic signaling pathway#GO:2001233;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;endoplasmic reticulum protein-containing complex#GO:0140534;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 chaperone#PC00072;Hsp70 family chaperone#PC00027 HUMAN|HGNC=28930|UniProtKB=Q5XKE5 Q5XKE5 KRT79 PTHR45616:SF10 GATA-TYPE DOMAIN-CONTAINING PROTEIN KERATIN, TYPE II CYTOSKELETAL 79 structural molecule activity#GO:0005198 anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;animal gross anatomical part developmental process#GO:0160108;keratinocyte differentiation#GO:0030216;intermediate filament-based process#GO:0045103;intermediate filament organization#GO:0045109;cell differentiation#GO:0030154;intermediate filament cytoskeleton organization#GO:0045104;cellular component organization#GO:0016043;animal organ development#GO:0048513;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;epidermis development#GO:0008544;developmental process#GO:0032502;tissue development#GO:0009888;epithelial cell differentiation#GO:0030855;epidermal cell differentiation#GO:0009913;multicellular organismal process#GO:0032501;epithelium development#GO:0060429;skin development#GO:0043588;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;organelle#GO:0043226;supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;intracellular anatomical structure#GO:0005622;intermediate filament#GO:0005882;supramolecular fiber#GO:0099512;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 HUMAN|HGNC=15335|UniProtKB=Q8NGE2 Q8NGE2 OR2AP1 PTHR26454:SF16 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2AP1 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=18096|UniProtKB=Q30KQ5 Q30KQ5 DEFB115 PTHR15001:SF9 BETA-DEFENSIN 123-RELATED BETA-DEFENSIN 115 immune system process#GO:0002376;cell killing#GO:0001906;innate immune response#GO:0045087;response to external stimulus#GO:0009605;defense response#GO:0006952;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;defense response to symbiont#GO:0140546;immune response#GO:0006955;cellular process#GO:0009987;response to stimulus#GO:0050896;defense response to other organism#GO:0098542;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to other organism#GO:0051707 defense/immunity protein#PC00090;antimicrobial response protein#PC00051 HUMAN|HGNC=16457|UniProtKB=P57077 P57077 MAP3K7CL PTHR47140:SF1 MAP3K7 C-TERMINAL-LIKE PROTEIN MAP3K7 C-TERMINAL-LIKE PROTEIN Wnt signaling pathway#P00057>TGFbetaactivated Kinase-1#P01442;TGF-beta signaling pathway#P00052>TAK#P01285;Ras Pathway#P04393>TAK#P04575 HUMAN|HGNC=25207|UniProtKB=Q8WV92 Q8WV92 MITD1 PTHR21222:SF1 MIT DOMAIN-CONTAINING PROTEIN 1 MIT DOMAIN-CONTAINING PROTEIN 1 cytokinesis#GO:0000910;cytokinetic process#GO:0032506;cytoskeleton-dependent cytokinesis#GO:0061640;cellular component organization or biogenesis#GO:0071840;mitotic cytokinetic process#GO:1902410;mitotic cell cycle process#GO:1903047;cell cycle#GO:0007049;cellular component organization#GO:0016043;cell cycle process#GO:0022402;cell division#GO:0051301;cellular process#GO:0009987;mitotic cell cycle#GO:0000278;mitotic cytokinesis#GO:0000281;membrane organization#GO:0061024 cellular anatomical structure#GO:0110165;midbody#GO:0030496 HUMAN|Gene=YG039_HUMAN|UniProtKB=Q8N976 Q8N976 PTHR12138:SF156 PRIMATE-EXPANDED PROTEIN FAMILY LMO7 DOWNSTREAM NEIGHBOR PROTEIN HUMAN|HGNC=9308|UniProtKB=Q15257 Q15257 PTPA PTHR10012:SF0 SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR phosphatase regulator activity#GO:0019208;catalytic activity, acting on a protein#GO:0140096;molecular function regulator activity#GO:0098772;phosphatase activator activity#GO:0019211;isomerase activity#GO:0016853;peptidyl-prolyl cis-trans isomerase activity#GO:0003755;enzyme activator activity#GO:0008047;catalytic activity#GO:0003824;enzyme regulator activity#GO:0030234;cis-trans isomerase activity#GO:0016859;molecular function activator activity#GO:0140677;protein phosphatase regulator activity#GO:0019888 microtubule-based process#GO:0007017;mitotic cell cycle process#GO:1903047;microtubule cytoskeleton organization#GO:0000226;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010;mitotic spindle organization#GO:0007052;mitotic cell cycle#GO:0000278;cellular process#GO:0009987;cell cycle process#GO:0022402;cellular component organization#GO:0016043;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cell cycle#GO:0007049;organelle organization#GO:0006996 intracellular organelle#GO:0043229;protein serine/threonine phosphatase complex#GO:0008287;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 phosphatase activator#PC00182 HUMAN|HGNC=100|UniProtKB=P78348 P78348 ASIC1 PTHR11690:SF170 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED ACID-SENSING ION CHANNEL 1 ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;sodium channel activity#GO:0005272;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261 transport#GO:0006810;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;sodium ion transport#GO:0006814;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=25950|UniProtKB=Q6V9R5 Q6V9R5 ZNF562 PTHR24384:SF248 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED ZINC FINGER PROTEIN 562 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218 HUMAN|HGNC=11255|UniProtKB=P10451 P10451 SPP1 PTHR10607:SF1 OSTEOPONTIN OSTEOPONTIN signaling receptor binding#GO:0005102;binding#GO:0005488;cell adhesion molecule binding#GO:0050839;protein binding#GO:0005515;integrin binding#GO:0005178;protein-containing complex binding#GO:0044877 cellular process#GO:0009987;ossification#GO:0001503;multicellular organismal process#GO:0032501;tissue development#GO:0009888;bone mineralization#GO:0030282;animal gross anatomical part developmental process#GO:0160108;biomineral tissue development#GO:0031214;developmental process#GO:0032502;cell adhesion#GO:0007155;animal organ development#GO:0048513;anatomical structure development#GO:0048856 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 cytokine#PC00083;intercellular signal molecule#PC00207 HUMAN|HGNC=23258|UniProtKB=Q96JC4 Q96JC4 ZNF479 PTHR24384:SF228 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED ZINC FINGER PROTEIN 479-RELATED sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 HUMAN|HGNC=25334|UniProtKB=Q8N336 Q8N336 ELMOD1 PTHR12771:SF18 ENGULFMENT AND CELL MOTILITY ELMO DOMAIN-CONTAINING PROTEIN 1 enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589 organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031;cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component assembly#GO:0022607;cell projection organization#GO:0030030;plasma membrane bounded cell projection organization#GO:0120036 cell projection#GO:0042995;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;synapse#GO:0045202;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cell junction#GO:0030054;cilium#GO:0005929;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794 scaffold/adaptor protein#PC00226 HUMAN|HGNC=7037|UniProtKB=P08582 P08582 MELTF PTHR11485:SF21 TRANSFERRIN MELANOTRANSFERRIN transition metal ion transport#GO:0000041;transport#GO:0006810;iron ion transport#GO:0006826;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;metal ion transport#GO:0030001 intracellular organelle#GO:0043229;endosome#GO:0005768;extracellular region#GO:0005576;membrane-bounded organelle#GO:0043227;early endosome#GO:0005769;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;recycling endosome#GO:0055037;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;endomembrane system#GO:0012505 transfer/carrier protein#PC00219 HUMAN|HGNC=16298|UniProtKB=Q504T8 Q504T8 MIDN PTHR23010:SF1 MIDNOLIN MIDNOLIN intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=12423|UniProtKB=O00294 O00294 TULP1 PTHR16517:SF12 TUBBY-RELATED TUBBY-RELATED PROTEIN 1 protein-containing complex binding#GO:0044877;protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;actin filament binding#GO:0051015;binding#GO:0005488 macromolecule localization#GO:0033036;protein localization to organelle#GO:0033365;localization#GO:0051179;intracellular protein localization#GO:0008104;protein localization to cilium#GO:0061512 cilium#GO:0005929;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 scaffold/adaptor protein#PC00226 HUMAN|HGNC=12203|UniProtKB=A0A075B6N3 A0A075B6N3 TRBV24-1 PTHR23268:SF54 T-CELL RECEPTOR BETA CHAIN T CELL RECEPTOR BETA VARIABLE 24-1 cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=9773|UniProtKB=Q14088 Q14088 RAB33A PTHR47978:SF30 FAMILY NOT NAMED RAS-RELATED PROTEIN RAB-33A ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleotide binding#GO:0000166;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;anion binding#GO:0043168;small molecule binding#GO:0036094;GTPase activity#GO:0003924;ion binding#GO:0043167;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;hydrolase activity, acting on acid anhydrides#GO:0016817;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;nucleoside phosphate binding#GO:1901265;guanyl nucleotide binding#GO:0019001 vacuole organization#GO:0007033;autophagosome assembly#GO:0000045;process utilizing autophagic mechanism#GO:0061919;cellular component organization or biogenesis#GO:0071840;organelle assembly#GO:0070925;metabolic process#GO:0008152;macroautophagy#GO:0016236;cellular component assembly#GO:0022607;catabolic process#GO:0009056;autophagy#GO:0006914;cellular process#GO:0009987;autophagosome organization#GO:1905037;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular component organization#GO:0016043 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;vesicle#GO:0031982;intracellular vesicle#GO:0097708;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794 small GTPase#PC00208 HUMAN|HGNC=3785|UniProtKB=P49356 P49356 FNTB PTHR11774:SF6 GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT PROTEIN FARNESYLTRANSFERASE SUBUNIT BETA transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;prenyltransferase activity#GO:0004659;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 transferase#PC00220;acyltransferase#PC00042 HUMAN|HGNC=29572|UniProtKB=Q86X29 Q86X29 LSR PTHR15923:SF1 TRANSMEMBRANE AND IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN LIPOLYSIS-STIMULATED LIPOPROTEIN RECEPTOR anatomical structure development#GO:0048856;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;cell junction organization#GO:0034330;central nervous system development#GO:0007417;cell differentiation#GO:0030154;cell development#GO:0048468;cellular component organization#GO:0016043;cell junction assembly#GO:0034329;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cell-cell junction assembly#GO:0007043;developmental process#GO:0032502;cell-cell junction organization#GO:0045216;multicellular organismal process#GO:0032501;cellular component assembly#GO:0022607;nervous system development#GO:0007399;cellular component biogenesis#GO:0044085;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;cell-cell junction#GO:0005911;membrane#GO:0016020;anchoring junction#GO:0070161;cell junction#GO:0030054;tight junction#GO:0070160 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=20327|UniProtKB=Q5T8P6 Q5T8P6 RBM26 PTHR14398:SF2 RNA RECOGNITION RRM/RNP DOMAIN RNA-BINDING PROTEIN 26 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 RNA metabolism protein#PC00031 HUMAN|HGNC=21182|UniProtKB=Q8NFH3 Q8NFH3 NUP43 PTHR22652:SF0 NUCLEOPORIN NUP43 NUCLEOPORIN NUP43 intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;nuclear pore outer ring#GO:0031080;organelle envelope#GO:0031967;nuclear pore#GO:0005643;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229 transporter#PC00227 HUMAN|HGNC=16017|UniProtKB=Q6P1L6 Q6P1L6 ZNF343 PTHR24381:SF97 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 343 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=27558|UniProtKB=Q4G0I0 Q4G0I0 UQCC4 PTHR35268:SF1 PROTEIN CCSMST1 UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX ASSEMBLY FACTOR 4 cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;mitochondrion organization#GO:0007005;mitochondrial respiratory chain complex assembly#GO:0033108;mitochondrial respiratory chain complex III assembly#GO:0034551;cellular component assembly#GO:0022607;cytochrome complex assembly#GO:0017004;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020 HUMAN|HGNC=23466|UniProtKB=Q5VW22 Q5VW22 AGAP6 PTHR45819:SF7 CENTAURIN-GAMMA-1A ARF-GAP WITH GTPASE, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 4-RELATED catalytic activity#GO:0003824;enzyme activator activity#GO:0008047;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;ribonucleoside triphosphate phosphatase activity#GO:0017111;molecular function regulator activity#GO:0098772;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924;enzyme regulator activity#GO:0030234;hydrolase activity#GO:0016787;molecular function activator activity#GO:0140677 GTPase-activating protein#PC00257;G-protein modulator#PC00022 HUMAN|HGNC=23841|UniProtKB=Q9C0E4 Q9C0E4 GRIP2 PTHR46227:SF4 GLUTAMATE RECEPTOR-INTERACTING PROTEIN GRIP GLUTAMATE RECEPTOR-INTERACTING PROTEIN 2 protein localization to membrane#GO:0072657;protein localization to plasma membrane#GO:0072659;endocytic recycling#GO:0032456;protein localization to cell junction#GO:1902414;localization within membrane#GO:0051668;establishment of protein localization to plasma membrane#GO:0061951;localization#GO:0051179;cellular localization#GO:0051641;protein transport#GO:0015031;regulation of biological quality#GO:0065008;macromolecule localization#GO:0033036;establishment of protein localization to membrane#GO:0090150;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;endosome to plasma membrane protein transport#GO:0099638;vesicle-mediated transport#GO:0016192;biological regulation#GO:0065007;protein localization to cell periphery#GO:1990778;intracellular transport#GO:0046907;regulation of postsynaptic membrane neurotransmitter receptor levels#GO:0099072;intracellular protein transport#GO:0006886;transport#GO:0006810;protein localization to synapse#GO:0035418;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;vesicle-mediated transport to the plasma membrane#GO:0098876;endosomal transport#GO:0016197;neurotransmitter receptor transport to postsynaptic membrane#GO:0098969 HUMAN|HGNC=8848|UniProtKB=O00541 O00541 PES1 PTHR12221:SF8 PESCADILLO - RELATED PESCADILLO HOMOLOG binding#GO:0005488;nucleic acid binding#GO:0003676;rRNA binding#GO:0019843;RNA binding#GO:0003723 rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;ribosomal large subunit biogenesis#GO:0042273;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;biosynthetic process#GO:0009058;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;maturation of LSU-rRNA#GO:0000470;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085 membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;preribosome#GO:0030684;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;organelle lumen#GO:0043233;90S preribosome#GO:0030686 RNA metabolism protein#PC00031 HUMAN|HGNC=24767|UniProtKB=Q6ZV70 Q6ZV70 LANCL3 PTHR12736:SF29 LANC-LIKE PROTEIN LANC-LIKE PROTEIN 3 biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of cellular response to alcohol#GO:1905957;regulation of biological process#GO:0050789;regulation of response to alcohol#GO:1901419;regulation of abscisic acid-activated signaling pathway#GO:0009787;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583 HUMAN|HGNC=25239|UniProtKB=Q6UWY0 Q6UWY0 ARSK PTHR46615:SF1 ARYLSULFATASE K ARYLSULFATASE K hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788 HUMAN|HGNC=9491|UniProtKB=Q16651 Q16651 PRSS8 PTHR24253:SF169 TRANSMEMBRANE PROTEASE SERINE PROSTASIN serine hydrolase activity#GO:0017171;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;serine-type peptidase activity#GO:0008236 metabolic process#GO:0008152;regulation of localization#GO:0032879;regulation of transport#GO:0051049;macromolecule metabolic process#GO:0043170;protein processing#GO:0016485;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;positive regulation of transport#GO:0051050;positive regulation of biological process#GO:0048518;biosynthetic process#GO:0009058;biological regulation#GO:0065007;protein maturation#GO:0051604;gene expression#GO:0010467;regulation of monoatomic ion transport#GO:0043269;proteolysis#GO:0006508;protein metabolic process#GO:0019538;regulation of biological process#GO:0050789;primary metabolic process#GO:0044238;regulation of metal ion transport#GO:0010959 protein modifying enzyme#PC00260;protease#PC00190;serine protease#PC00203 HUMAN|HGNC=29932|UniProtKB=Q13057 Q13057 COASY PTHR10695:SF60 DEPHOSPHO-COA KINASE-RELATED BIFUNCTIONAL COENZYME A SYNTHASE phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;adenylyltransferase activity#GO:0070566;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779 phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;purine-containing compound metabolic process#GO:0072521;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound biosynthetic process#GO:0072522;organophosphate biosynthetic process#GO:0090407;organophosphate metabolic process#GO:0019637;sulfur compound metabolic process#GO:0006790;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing small molecule metabolic process#GO:0055086 intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;kinase#PC00137 HUMAN|HGNC=18423|UniProtKB=O75140 O75140 DEPDC5 PTHR13179:SF8 DEP DOMAIN CONTAINING PROTEIN 5 GATOR1 COMPLEX PROTEIN DEPDC5 response to nutrient levels#GO:0031667;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;negative regulation of response to stimulus#GO:0048585;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;cellular response to starvation#GO:0009267;negative regulation of cellular process#GO:0048523;cellular response to nutrient levels#GO:0031669;regulation of response to stimulus#GO:0048583;positive regulation of catabolic process#GO:0009896;regulation of TORC1 signaling#GO:1903432;regulation of catabolic process#GO:0009894;response to starvation#GO:0042594;cellular response to stimulus#GO:0051716;negative regulation of TOR signaling#GO:0032007;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;positive regulation of autophagy#GO:0010508;response to stress#GO:0006950;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of TOR signaling#GO:0032006;cellular response to amino acid starvation#GO:0034198;negative regulation of signal transduction#GO:0009968;negative regulation of TORC1 signaling#GO:1904262;negative regulation of biological process#GO:0048519;regulation of autophagy#GO:0010506;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;cellular response to stress#GO:0033554;regulation of signaling#GO:0023051;positive regulation of metabolic process#GO:0009893;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648 lysosomal membrane#GO:0005765;membrane#GO:0016020;cytoplasm#GO:0005737;vacuole#GO:0005773;protein-containing complex#GO:0032991;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;vacuolar membrane#GO:0005774;lytic vacuole#GO:0000323;lysosome#GO:0005764;lytic vacuole membrane#GO:0098852;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Seh1-associated complex#GO:0035859 GTPase-activating protein#PC00257;protein-binding activity modulator#PC00095 HUMAN|HGNC=81|UniProtKB=Q12979 Q12979 ABR PTHR23182:SF5 BREAKPOINT CLUSTER REGION PROTEIN BCR ACTIVE BREAKPOINT CLUSTER REGION-RELATED PROTEIN enzyme activator activity#GO:0008047;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096 regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;regulation of small GTPase mediated signal transduction#GO:0051056;regulation of biological process#GO:0050789;regulation of cell communication#GO:0010646;modulation of chemical synaptic transmission#GO:0050804;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of trans-synaptic signaling#GO:0099177;regulation of Rho protein signal transduction#GO:0035023;regulation of cellular process#GO:0050794 glutamatergic synapse#GO:0098978;neuron to neuron synapse#GO:0098984;synapse#GO:0045202;cellular anatomical structure#GO:0110165;postsynaptic specialization#GO:0099572;organelle#GO:0043226;asymmetric synapse#GO:0032279;plasma membrane#GO:0005886;membrane#GO:0016020;postsynapse#GO:0098794;cell periphery#GO:0071944;cell junction#GO:0030054;postsynaptic density#GO:0014069 G-protein modulator#PC00022 HUMAN|HGNC=5975|UniProtKB=Q14627 Q14627 IL13RA2 PTHR23036:SF101 CYTOKINE RECEPTOR INTERLEUKIN-13 RECEPTOR SUBUNIT ALPHA-2 molecular transducer activity#GO:0060089;protein binding#GO:0005515;transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488;signaling receptor activity#GO:0038023;cytokine binding#GO:0019955;immune receptor activity#GO:0140375;cytokine receptor activity#GO:0004896 response to peptide#GO:1901652;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;cytokine-mediated signaling pathway#GO:0019221;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;positive regulation of cell population proliferation#GO:0008284;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;response to cytokine#GO:0034097;response to chemical#GO:0042221;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518 signaling receptor complex#GO:0043235;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 transmembrane signal receptor#PC00197 Interleukin signaling pathway#P00036>Receptor subunit alpha#P00992 HUMAN|HGNC=3499|UniProtKB=P22794 P22794 EVI2A PTHR15568:SF0 ECOTROPIC VIRAL INTEGRATION SITE 2A PROTEIN EVI2A transmembrane signal receptor#PC00197 HUMAN|HGNC=13672|UniProtKB=Q9Y2Y9 Q9Y2Y9 KLF13 PTHR23235:SF21 KRUEPPEL-LIKE TRANSCRIPTION FACTOR KRUEPPEL-LIKE FACTOR 13 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=2963|UniProtKB=O14576 O14576 DYNC1I1 PTHR12442:SF34 DYNEIN INTERMEDIATE CHAIN CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN 1 protein binding#GO:0005515;binding#GO:0005488 establishment of localization in cell#GO:0051649;cellular process#GO:0009987;cytoskeleton-dependent intracellular transport#GO:0030705;microtubule-based movement#GO:0007018;microtubule-based transport#GO:0099111;transport#GO:0006810;intracellular transport#GO:0046907;microtubule-based process#GO:0007017;localization#GO:0051179;transport along microtubule#GO:0010970;cellular localization#GO:0051641;establishment of localization#GO:0051234 cytoskeleton#GO:0005856;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoplasmic dynein complex#GO:0005868;microtubule cytoskeleton#GO:0015630;dynein complex#GO:0030286;microtubule associated complex#GO:0005875;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232 microtubule or microtubule-binding cytoskeletal protein#PC00157 Huntington disease#P00029>Dynein complex#P00774 HUMAN|HGNC=40040|UniProtKB=A1L1A6 A1L1A6 IGSF23 PTHR44337:SF13 CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 8 IMMUNOGLOBULIN SUPERFAMILY MEMBER 23 cell-cell adhesion#GO:0098609;homophilic cell-cell adhesion#GO:0007156;heterophilic cell-cell adhesion#GO:0007157;cellular process#GO:0009987;cell adhesion#GO:0007155 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 immunoglobulin superfamily cell adhesion molecule#PC00125;cell adhesion molecule#PC00069 HUMAN|HGNC=30012|UniProtKB=Q9HBH1 Q9HBH1 PDF PTHR10458:SF2 PEPTIDE DEFORMYLASE PEPTIDE DEFORMYLASE, MITOCHONDRIAL intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 hydrolase#PC00121 HUMAN|HGNC=30319|UniProtKB=Q86YR7 Q86YR7 MCF2L2 PTHR22826:SF201 RHO GUANINE EXCHANGE FACTOR-RELATED GUANINE NUCLEOTIDE EXCHANGE FACTOR MCF2L2-RELATED guanyl-nucleotide exchange factor activity#GO:0005085;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protein-binding activity modulator#PC00095;guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=6027|UniProtKB=P25025 P25025 CXCR2 PTHR10489:SF689 CELL ADHESION MOLECULE C-X-C CHEMOKINE RECEPTOR TYPE 2 transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488;protein binding#GO:0005515;molecular transducer activity#GO:0060089;cytokine receptor activity#GO:0004896;signaling receptor activity#GO:0038023;cytokine binding#GO:0019955;immune receptor activity#GO:0140375;G protein-coupled receptor activity#GO:0004930 granulocyte migration#GO:0097530;taxis#GO:0042330;neutrophil migration#GO:1990266;response to chemical#GO:0042221;intracellular signaling cassette#GO:0141124;cellular process#GO:0009987;signal transduction#GO:0007165;neutrophil chemotaxis#GO:0030593;granulocyte chemotaxis#GO:0071621;response to stimulus#GO:0050896;signaling#GO:0023052;regulation of biological process#GO:0050789;regulation of biological quality#GO:0065008;cellular response to chemical stimulus#GO:0070887;immune system process#GO:0002376;positive regulation of cytosolic calcium ion concentration#GO:0007204;cell migration#GO:0016477;biological regulation#GO:0065007;immune response#GO:0006955;calcium-mediated signaling#GO:0019722;leukocyte chemotaxis#GO:0030595;myeloid leukocyte migration#GO:0097529;response to external stimulus#GO:0009605;leukocyte migration#GO:0050900;regulation of cellular process#GO:0050794;cell motility#GO:0048870;locomotion#GO:0040011;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cell chemotaxis#GO:0060326;chemotaxis#GO:0006935 membrane#GO:0016020;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;plasma membrane#GO:0005886 cell adhesion molecule#PC00069 Interleukin signaling pathway#P00036>Receptor subunit beta#P00974;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CHKR#P00854 HUMAN|HGNC=26139|UniProtKB=Q0VDI3 Q0VDI3 TMEM267 PTHR13628:SF1 TRANSMEMBRANE PROTEIN 267 TRANSMEMBRANE PROTEIN 267 HUMAN|HGNC=13254|UniProtKB=Q9UET6 Q9UET6 FTSJ1 PTHR10920:SF12 RIBOSOMAL RNA METHYLTRANSFERASE TRNA (CYTIDINE(32)_GUANOSINE(34)-2'-O)-METHYLTRANSFERASE catalytic activity, acting on a tRNA#GO:0140101;tRNA (guanine) methyltransferase activity#GO:0016423;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;catalytic activity, acting on RNA#GO:0140098;RNA methyltransferase activity#GO:0008173;tRNA methyltransferase activity#GO:0008175;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a nucleic acid#GO:0140640 nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;tRNA methylation#GO:0030488;cellular process#GO:0009987;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187;macromolecule methylation#GO:0043414;RNA methylation#GO:0001510;methylation#GO:0032259;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;tRNA modification#GO:0006400;RNA biosynthetic process#GO:0032774 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 RNA methyltransferase#PC00033 HUMAN|HGNC=9772|UniProtKB=Q13637 Q13637 RAB32 PTHR24073:SF1252 DRAB5-RELATED RAS-RELATED PROTEIN RAB-32 hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787 pigmentation#GO:0043473;cellular localization#GO:0051641;localization#GO:0051179;protein transport#GO:0015031;cellular response to stimulus#GO:0051716;cell differentiation#GO:0030154;response to stimulus#GO:0050896;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810;developmental process#GO:0032502;establishment of localization#GO:0051234;cellular developmental process#GO:0048869;response to external stimulus#GO:0009605;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;developmental pigmentation#GO:0048066;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;developmental maturation#GO:0021700;cellular pigmentation#GO:0033059 Golgi apparatus#GO:0005794;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;melanosome#GO:0042470;endomembrane system#GO:0012505;Golgi apparatus subcompartment#GO:0098791;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;mitochondrion#GO:0005739;intracellular vesicle#GO:0097708 G-protein#PC00020;small GTPase#PC00208 HUMAN|HGNC=32669|UniProtKB=Q2Q1W2 Q2Q1W2 TRIM71 PTHR24104:SF55 E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED E3 UBIQUITIN-PROTEIN LIGASE TRIM71 transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;nucleic acid binding#GO:0003676;binding#GO:0005488;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;RNA binding#GO:0003723 regulation of biological process#GO:0050789;modification-dependent protein catabolic process#GO:0019941;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;protein modification process#GO:0036211;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;cellular process#GO:0009987;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;proteasomal protein catabolic process#GO:0010498;post-translational protein modification#GO:0043687;biological regulation#GO:0065007;protein ubiquitination#GO:0016567;macromolecule catabolic process#GO:0009057;post-transcriptional regulation of gene expression#GO:0010608;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170 cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;organelle#GO:0043226;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;P-body#GO:0000932;intracellular organelle#GO:0043229 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=8052|UniProtKB=Q9UKK9 Q9UKK9 NUDT5 PTHR11839:SF24 UDP/ADP-SUGAR PYROPHOSPHATASE ADP-SUGAR PYROPHOSPHATASE pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787 carbohydrate derivative metabolic process#GO:1901135;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;nucleobase-containing compound metabolic process#GO:0006139;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 pyrophosphatase#PC00196;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=2843|UniProtKB=O75907 O75907 DGAT1 PTHR10408:SF7 STEROL O-ACYLTRANSFERASE DIACYLGLYCEROL O-ACYLTRANSFERASE 1 acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;glycerolipid metabolic process#GO:0046486;triglyceride biosynthetic process#GO:0019432;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;primary metabolic process#GO:0044238;neutral lipid metabolic process#GO:0006638;lipid metabolic process#GO:0006629;triglyceride metabolic process#GO:0006641;acylglycerol metabolic process#GO:0006639;metabolic process#GO:0008152 intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020 acyltransferase#PC00042;transferase#PC00220 Androgen/estrogene/progesterone biosynthesis#P02727>Cholesterol acyltransferase#P02829 HUMAN|HGNC=11252|UniProtKB=Q9HCB6 Q9HCB6 SPON1 PTHR11311:SF16 SPONDIN SPONDIN-1 cellular process#GO:0009987;cell adhesion#GO:0007155 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 cell adhesion molecule#PC00069 HUMAN|HGNC=7852|UniProtKB=O00746 O00746 NME4 PTHR11349:SF49 NUCLEOSIDE DIPHOSPHATE KINASE NUCLEOSIDE DIPHOSPHATE KINASE D, MITOCHONDRIAL phosphotransferase activity, phosphate group as acceptor#GO:0016776;nucleoside diphosphate kinase activity#GO:0004550;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;nucleobase-containing compound kinase activity#GO:0019205;catalytic activity#GO:0003824 nucleoside triphosphate metabolic process#GO:0009141;biosynthetic process#GO:0009058;cellular process#GO:0009987;phosphorus metabolic process#GO:0006793;nucleoside triphosphate biosynthetic process#GO:0009142;metabolic process#GO:0008152 mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 kinase#PC00137;transferase#PC00220 De novo purine biosynthesis#P02738>dADP kinase#P02907;De novo pyrimidine ribonucleotides biosythesis#P02740>CDP kinase#P02929;De novo purine biosynthesis#P02738>dGDP kinase#P02889;De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>dCDP kinase#P02914;De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>dTDP kinase#P02919;De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>dUDP kinase#P02912;De novo purine biosynthesis#P02738>GDP kinase#P02891;Salvage pyrimidine ribonucleotides#P02775>CDP kinase#P03156 HUMAN|HGNC=12996|UniProtKB=O95201 O95201 ZNF205 PTHR23226:SF379 ZINC FINGER AND SCAN DOMAIN-CONTAINING TRANSCRIPTIONAL REPRESSOR RHIT binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=12509|UniProtKB=Q9UHD9 Q9UHD9 UBQLN2 PTHR10677:SF5 UBIQUILIN UBIQUILIN-2 protein binding#GO:0005515;modification-dependent protein binding#GO:0140030;binding#GO:0005488;polyubiquitin modification-dependent protein binding#GO:0031593 cellular component organization or biogenesis#GO:0071840;autophagosome assembly#GO:0000045;regulation of macroautophagy#GO:0016241;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;response to chemical#GO:0042221;cellular component assembly#GO:0022607;proteasomal protein catabolic process#GO:0010498;response to stress#GO:0006950;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;autophagosome organization#GO:1905037;autophagy#GO:0006914;process utilizing autophagic mechanism#GO:0061919;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;cellular component organization#GO:0016043;regulation of autophagy#GO:0010506;regulation of biological process#GO:0050789;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;regulation of catabolic process#GO:0009894;macroautophagy#GO:0016236;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;protein metabolic process#GO:0019538;ERAD pathway#GO:0036503;vacuole organization#GO:0007033;response to endoplasmic reticulum stress#GO:0034976;organelle assembly#GO:0070925;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;modification-dependent protein catabolic process#GO:0019941 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 scaffold/adaptor protein#PC00226 HUMAN|HGNC=30412|UniProtKB=Q8WTS6 Q8WTS6 SETD7 PTHR46820:SF1 HISTONE-LYSINE N-METHYLTRANSFERASE SETD7 HISTONE-LYSINE N-METHYLTRANSFERASE SETD7 histone modifying activity#GO:0140993;histone H3 methyltransferase activity#GO:0140938;lysine N-methyltransferase activity#GO:0016278;N-methyltransferase activity#GO:0008170;protein-lysine N-methyltransferase activity#GO:0016279;histone methyltransferase activity#GO:0042054;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;catalytic activity, acting on a protein#GO:0140096;protein methyltransferase activity#GO:0008276;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity#GO:0003824;transferase activity#GO:0016740 regulation of biological process#GO:0050789;cellular component organization#GO:0016043;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of DNA-templated transcription#GO:0006355;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of RNA biosynthetic process#GO:1902680;chromatin organization#GO:0006325;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;heterochromatin organization#GO:0070828;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;regulation of gene expression#GO:0010468;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889 chromosome#GO:0005694;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 histone modifying enzyme#PC00261 HUMAN|HGNC=4938|UniProtKB=P20036 P20036 HLA-DPA1 PTHR19944:SF64 MHC CLASS II-RELATED HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DP ALPHA 1 CHAIN protein-containing complex binding#GO:0044877;antigen binding#GO:0003823;peptide binding#GO:0042277;binding#GO:0005488 regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;regulation of leukocyte cell-cell adhesion#GO:1903037;positive regulation of cellular process#GO:0048522;positive regulation of cell activation#GO:0050867;biological regulation#GO:0065007;positive regulation of leukocyte cell-cell adhesion#GO:1903039;regulation of cell adhesion#GO:0030155;positive regulation of response to stimulus#GO:0048584;regulation of immune response#GO:0050776;antigen processing and presentation#GO:0019882;positive regulation of lymphocyte activation#GO:0051251;positive regulation of cell adhesion#GO:0045785;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of cell-cell adhesion#GO:0022407;positive regulation of leukocyte activation#GO:0002696;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of immune system process#GO:0002684;cellular component biogenesis#GO:0044085;positive regulation of cell-cell adhesion#GO:0022409;regulation of multicellular organismal process#GO:0051239;regulation of T cell activation#GO:0050863;cellular component assembly#GO:0022607;positive regulation of T cell activation#GO:0050870;immune system process#GO:0002376;positive regulation of multicellular organismal process#GO:0051240;regulation of cell activation#GO:0050865;protein-containing complex assembly#GO:0065003;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;regulation of leukocyte activation#GO:0002694;regulation of lymphocyte activation#GO:0051249 membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endosome#GO:0005768;endosome membrane#GO:0010008;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;plasma membrane protein complex#GO:0098797;lysosome#GO:0005764;lytic vacuole membrane#GO:0098852;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;lytic vacuole#GO:0000323;vacuolar membrane#GO:0005774;late endosome membrane#GO:0031902;plasma membrane#GO:0005886;vacuole#GO:0005773;cytoplasm#GO:0005737;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;late endosome#GO:0005770;cytoplasmic vesicle membrane#GO:0030659;cell periphery#GO:0071944;lysosomal membrane#GO:0005765;vesicle membrane#GO:0012506;membrane#GO:0016020 major histocompatibility complex protein#PC00149 T cell activation#P00053>MHC-antigen#P01316 HUMAN|HGNC=5417|UniProtKB=P0DY56 P0DY56 IFNA1 PTHR11691:SF64 TYPE I INTERFERON INTERFERON ALPHA-1-RELATED receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;cytokine activity#GO:0005125;binding#GO:0005488;cytokine receptor binding#GO:0005126;signaling receptor binding#GO:0005102;protein binding#GO:0005515;molecular function activator activity#GO:0140677;protein-containing complex binding#GO:0044877 natural killer cell activation#GO:0030101;immune effector process#GO:0002252;leukocyte activation involved in immune response#GO:0002366;cell surface receptor signaling pathway#GO:0007166;humoral immune response#GO:0006959;B cell activation#GO:0042113;cellular process#GO:0009987;signal transduction#GO:0007165;lymphocyte activation involved in immune response#GO:0002285;defense response to symbiont#GO:0140546;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;T cell activation involved in immune response#GO:0002286;defense response to other organism#GO:0098542;response to chemical#GO:0042221;lymphocyte activation#GO:0046649;response to cytokine#GO:0034097;type I interferon-mediated signaling pathway#GO:0060337;B cell activation involved in immune response#GO:0002312;immune system process#GO:0002376;response to peptide#GO:1901652;cell activation involved in immune response#GO:0002263;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;T cell activation#GO:0042110;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;defense response#GO:0006952;response to external stimulus#GO:0009605;innate immune response#GO:0045087;immune response#GO:0006955;adaptive immune response#GO:0002250;response to other organism#GO:0051707;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;cell activation#GO:0001775;cytokine-mediated signaling pathway#GO:0019221;response to nitrogen compound#GO:1901698;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;leukocyte activation#GO:0045321;response to external biotic stimulus#GO:0043207;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 interferon superfamily#PC00127;cytokine#PC00083 HUMAN|HGNC=16354|UniProtKB=Q8IWW8 Q8IWW8 ADHFE1 PTHR11496:SF83 ALCOHOL DEHYDROGENASE HYDROXYACID-OXOACID TRANSHYDROGENASE, MITOCHONDRIAL catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;alcohol dehydrogenase (NAD+) activity#GO:0004022;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739 dehydrogenase#PC00092 HUMAN|HGNC=13752|UniProtKB=Q9NP98 Q9NP98 MYOZ1 PTHR15941:SF11 MYOZENIN MYOZENIN-1 molecular condensate scaffold activity#GO:0140693;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;muscle tissue development#GO:0060537;organelle assembly#GO:0070925;cellular component assembly involved in morphogenesis#GO:0010927;actin filament-based process#GO:0030029;sarcomere organization#GO:0045214;actin cytoskeleton organization#GO:0030036;muscle structure development#GO:0061061;muscle cell development#GO:0055001;myofibril assembly#GO:0030239;muscle cell differentiation#GO:0042692;cellular response to stimulus#GO:0051716;cellular developmental process#GO:0048869;system process#GO:0003008;developmental process#GO:0032502;tissue development#GO:0009888;multicellular organismal process#GO:0032501;skeletal muscle tissue development#GO:0007519;striated muscle cell development#GO:0055002;animal gross anatomical part developmental process#GO:0160108;skeletal muscle organ development#GO:0060538;response to stimulus#GO:0050896;cell differentiation#GO:0030154;actomyosin structure organization#GO:0031032;cell development#GO:0048468;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;muscle system process#GO:0003012;cellular component organization or biogenesis#GO:0071840;animal organ development#GO:0048513;striated muscle cell differentiation#GO:0051146;anatomical structure formation involved in morphogenesis#GO:0048646;muscle organ development#GO:0007517;cellular anatomical entity morphogenesis#GO:0032989;striated muscle tissue development#GO:0014706;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;organelle#GO:0043226;actin cytoskeleton#GO:0015629;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;myofibril#GO:0030016;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;Z disc#GO:0030018;contractile muscle fiber#GO:0043292;membraneless organelle#GO:0043228;sarcomere#GO:0030017;I band#GO:0031674;cytoskeleton#GO:0005856 non-motor actin binding protein#PC00165;actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=19309|UniProtKB=Q14678 Q14678 KANK1 PTHR24168:SF19 KN MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING KN MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 1 cellular component organization or biogenesis#GO:0071840;negative regulation of cellular process#GO:0048523;regulation of actin filament-based process#GO:0032970;regulation of anatomical structure size#GO:0090066;regulation of actin filament polymerization#GO:0030833;regulation of actin cytoskeleton organization#GO:0032956;regulation of actin polymerization or depolymerization#GO:0008064;biological regulation#GO:0065007;regulation of actin filament organization#GO:0110053;cellular process#GO:0009987;negative regulation of cytoskeleton organization#GO:0051494;regulation of biological quality#GO:0065008;negative regulation of protein-containing complex assembly#GO:0031333;regulation of actin filament length#GO:0030832;negative regulation of protein polymerization#GO:0032272;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of protein polymerization#GO:0032271;regulation of cytoskeleton organization#GO:0051493;negative regulation of supramolecular fiber organization#GO:1902904;regulation of cellular component biogenesis#GO:0044087;negative regulation of actin filament polymerization#GO:0030837;cellular component organization#GO:0016043;negative regulation of organelle organization#GO:0010639;negative regulation of cellular component organization#GO:0051129;regulation of protein-containing complex assembly#GO:0043254;negative regulation of biological process#GO:0048519;regulation of organelle organization#GO:0033043;regulation of supramolecular fiber organization#GO:1902903;regulation of cellular component size#GO:0032535;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 non-motor actin binding protein#PC00165 HUMAN|Ensembl=ENSG00000288354.1|UniProtKB=A0AAG2TTZ7 A0AAG2TTZ7 PTHR10881:SF7 GOLGIN SUBFAMILY A MEMBER-RELATED GOLGIN SUBFAMILY A CONSERVED DOMAIN-CONTAINING PROTEIN-RELATED cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;Golgi organization#GO:0007030;cellular component organization or biogenesis#GO:0071840;endomembrane system organization#GO:0010256 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;Golgi stack#GO:0005795;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;Golgi cis cisterna#GO:0000137;cytoplasm#GO:0005737;Golgi cisterna#GO:0031985;endomembrane system#GO:0012505;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;cis-Golgi network#GO:0005801;organelle membrane#GO:0031090;Golgi apparatus#GO:0005794 membrane traffic protein#PC00150 HUMAN|HGNC=15597|UniProtKB=Q969F9 Q969F9 HPS3 PTHR28633:SF1 HERMANSKY-PUDLAK SYNDROME 3 PROTEIN BLOC-2 COMPLEX MEMBER HPS3 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular protein-containing complex#GO:0140535 HUMAN|HGNC=29195|UniProtKB=Q9UPN7 Q9UPN7 PPP6R1 PTHR12634:SF13 SIT4 YEAST -ASSOCIATING PROTEIN-RELATED SERINE_THREONINE-PROTEIN PHOSPHATASE 6 REGULATORY SUBUNIT 1 phosphatase regulator activity#GO:0019208;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;protein phosphatase regulator activity#GO:0019888 regulation of cell communication#GO:0010646;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cellular process#GO:0050794;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 phosphatase modulator#PC00184 HUMAN|HGNC=14896|UniProtKB=Q9H254 Q9H254 SPTBN4 PTHR11915:SF232 SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN SPECTRIN BETA CHAIN, NON-ERYTHROCYTIC 4 protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;actin binding#GO:0003779;actin filament binding#GO:0051015;cytoskeletal protein binding#GO:0008092 neurogenesis#GO:0022008;cellular developmental process#GO:0048869;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;central nervous system neuron differentiation#GO:0021953;plasma membrane bounded cell projection organization#GO:0120036;multicellular organismal process#GO:0032501;axon development#GO:0061564;system development#GO:0048731;anatomical structure development#GO:0048856;actin filament-based process#GO:0030029;actin cytoskeleton organization#GO:0030036;cell projection morphogenesis#GO:0048858;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;cytoskeleton organization#GO:0007010;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;cellular process#GO:0009987;neuron projection development#GO:0031175;organelle organization#GO:0006996;axonogenesis#GO:0007409;neuron development#GO:0048666;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;cell differentiation#GO:0030154;central nervous system development#GO:0007417;cell projection organization#GO:0030030;cell morphogenesis#GO:0000902;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043 cytoplasm#GO:0005737;cortical actin cytoskeleton#GO:0030864;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;membrane#GO:0016020;cell periphery#GO:0071944;membraneless organelle#GO:0043228;cell junction#GO:0030054;cytoskeleton#GO:0005856;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cell projection#GO:0042995;cortical cytoskeleton#GO:0030863;actin cytoskeleton#GO:0015629;cell cortex#GO:0005938;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=11703|UniProtKB=P51864 P51864 CRIPTO3 PTHR14949:SF43 EGF-LIKE-DOMAIN, MULTIPLE 7, 8 PROTEIN CRIPTO3 binding#GO:0005488;signaling receptor binding#GO:0005102;receptor serine/threonine kinase binding#GO:0033612;protein binding#GO:0005515 left/right pattern formation#GO:0060972;cell surface receptor signaling pathway#GO:0007166;multicellular organism development#GO:0007275;animal organ development#GO:0048513;vasculature development#GO:0001944;signal transduction#GO:0007165;cellular process#GO:0009987;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;vasculogenesis#GO:0001570;heart development#GO:0007507;determination of bilateral symmetry#GO:0009855;animal gross anatomical part developmental process#GO:0160108;activin receptor signaling pathway#GO:0032924;blood vessel morphogenesis#GO:0048514;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;circulatory system development#GO:0072359;cell differentiation#GO:0030154;signaling#GO:0023052;specification of symmetry#GO:0009799;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;developmental process#GO:0032502;cellular developmental process#GO:0048869;multicellular organismal process#GO:0032501;regionalization#GO:0003002;biological regulation#GO:0065007;tube development#GO:0035295;pattern specification process#GO:0007389;cell communication#GO:0007154;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;system development#GO:0048731;determination of left/right symmetry#GO:0007368;tube morphogenesis#GO:0035239;cellular response to stimulus#GO:0051716;blood vessel development#GO:0001568;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;cell surface#GO:0009986;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HUMAN|Gene=YK041_HUMAN|UniProtKB=Q3C1V9 Q3C1V9 PTHR10404:SF81 N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE GLUTAMATE CARBOXYPEPTIDASE 2 catalytic activity#GO:0003824;peptidase activity#GO:0008233;carboxypeptidase activity#GO:0004180;catalytic activity, acting on a protein#GO:0140096;exopeptidase activity#GO:0008238;hydrolase activity#GO:0016787 metalloprotease#PC00153 HUMAN|HGNC=33862|UniProtKB=A6NFK2 A6NFK2 GRXCR2 PTHR46926:SF1 GLUTAREDOXIN DOMAIN-CONTAINING CYSTEINE-RICH PROTEIN 2 GLUTAREDOXIN DOMAIN-CONTAINING CYSTEINE-RICH PROTEIN 2 sensory perception#GO:0007600;sensory perception of mechanical stimulus#GO:0050954;nervous system process#GO:0050877;sensory perception of sound#GO:0007605;multicellular organismal process#GO:0032501;system process#GO:0003008 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;stereocilium#GO:0032420;intracellular anatomical structure#GO:0005622;cluster of actin-based cell projections#GO:0098862;membraneless organelle#GO:0043228;actin-based cell projection#GO:0098858;microvillus#GO:0005902;neuron projection#GO:0043005;actin cytoskeleton#GO:0015629;plasma membrane bounded cell projection#GO:0120025;intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226 oxidoreductase#PC00176 HUMAN|Ensembl=ENSG00000288339.1|UniProtKB=A0AAG2TVR5 A0AAG2TVR5 LOC124907502 PTHR10881:SF7 GOLGIN SUBFAMILY A MEMBER-RELATED GOLGIN SUBFAMILY A CONSERVED DOMAIN-CONTAINING PROTEIN-RELATED cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;Golgi organization#GO:0007030;cellular component organization or biogenesis#GO:0071840;endomembrane system organization#GO:0010256 Golgi stack#GO:0005795;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;Golgi cis cisterna#GO:0000137;cytoplasm#GO:0005737;Golgi cisterna#GO:0031985;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;cis-Golgi network#GO:0005801;organelle membrane#GO:0031090 membrane traffic protein#PC00150 HUMAN|HGNC=4826|UniProtKB=Q6B0K9 Q6B0K9 HBM PTHR11442:SF8 HEMOGLOBIN FAMILY MEMBER HEMOGLOBIN SUBUNIT MU tetrapyrrole binding#GO:0046906;molecular carrier activity#GO:0140104;binding#GO:0005488;heme binding#GO:0020037 hemopoiesis#GO:0030097;multicellular organismal process#GO:0032501;cellular process#GO:0009987;multicellular organismal-level homeostasis#GO:0048871;cellular developmental process#GO:0048869;establishment of localization#GO:0051234;transport#GO:0006810;developmental process#GO:0032502;cell development#GO:0048468;homeostatic process#GO:0042592;myeloid cell differentiation#GO:0030099;cell differentiation#GO:0030154;anatomical structure development#GO:0048856;erythrocyte differentiation#GO:0030218;localization#GO:0051179;homeostasis of number of cells#GO:0048872;immune system process#GO:0002376 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 transfer/carrier protein#PC00219;globin#PC00107 HUMAN|HGNC=26704|UniProtKB=Q3MJ40 Q3MJ40 CCDC144BP PTHR22245:SF3 COILED-COIL DOMAIN-CONTAINING PROTEIN 144A-RELATED COILED-COIL DOMAIN-CONTAINING PROTEIN 144A-RELATED HUMAN|HGNC=32431|UniProtKB=Q6UXZ0 Q6UXZ0 TMIGD1 PTHR12231:SF219 CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN TRANSMEMBRANE AND IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN 1 cell adhesion mediator activity#GO:0098631;cell adhesion molecule binding#GO:0050839;binding#GO:0005488;protein binding#GO:0005515 cell-cell adhesion#GO:0098609;cellular process#GO:0009987;cell adhesion#GO:0007155;cell migration#GO:0016477;cell motility#GO:0048870 cell junction#GO:0030054;plasma membrane#GO:0005886;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165;neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020 immunoglobulin superfamily cell adhesion molecule#PC00125;cell adhesion molecule#PC00069 HUMAN|HGNC=15771|UniProtKB=Q96SM3 Q96SM3 CPXM1 PTHR11532:SF43 PROTEASE M14 CARBOXYPEPTIDASE CARBOXYPEPTIDASE X1-RELATED metalloexopeptidase activity#GO:0008235;catalytic activity#GO:0003824;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;metallopeptidase activity#GO:0008237;carboxypeptidase activity#GO:0004180;hydrolase activity#GO:0016787;metallocarboxypeptidase activity#GO:0004181;exopeptidase activity#GO:0008238 protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein processing#GO:0016485;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;peptide metabolic process#GO:0006518;metabolic process#GO:0008152;proteolysis#GO:0006508 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease#PC00190 HUMAN|HGNC=13267|UniProtKB=O95424 O95424 DEXI PTHR17070:SF0 DEXAMETHASONE-INDUCED PROTEIN DEXAMETHASONE-INDUCED PROTEIN HUMAN|HGNC=29616|UniProtKB=Q8N137 Q8N137 CNTROB PTHR34439:SF1 CENTROBIN CENTROBIN cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;centrosome duplication#GO:0051298;microtubule-based process#GO:0007017;mitotic cell cycle process#GO:1903047;microtubule organizing center organization#GO:0031023;cellular component organization or biogenesis#GO:0071840;mitotic cytokinesis#GO:0000281;mitotic cell cycle#GO:0000278;cell division#GO:0051301;cell cycle process#GO:0022402;centrosome cycle#GO:0007098;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;cell cycle#GO:0007049;microtubule cytoskeleton organization#GO:0000226;mitotic cytokinetic process#GO:1902410;cytoskeleton-dependent cytokinesis#GO:0061640;cytokinetic process#GO:0032506;centriole replication#GO:0007099;cytokinesis#GO:0000910;organelle assembly#GO:0070925 cellular anatomical structure#GO:0110165;organelle#GO:0043226;centriole#GO:0005814;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;centrosome#GO:0005813;intracellular organelle#GO:0043229 HUMAN|HGNC=19910|UniProtKB=Q9H6R4 Q9H6R4 NOL6 PTHR17972:SF0 NUCLEOLAR RNA-ASSOCIATED PROTEIN NUCLEOLAR PROTEIN 6 cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;ribosomal small subunit biogenesis#GO:0042274;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;90S preribosome#GO:0030686;organelle lumen#GO:0043233;small-subunit processome#GO:0032040;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleolus#GO:0005730;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;preribosome#GO:0030684;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228 RNA metabolism protein#PC00031 HUMAN|HGNC=25197|UniProtKB=Q96AQ1 Q96AQ1 CCDC74A PTHR14882:SF7 COILED-COIL DOMAIN-CONTAINING 74A COILED-COIL DOMAIN-CONTAINING PROTEIN 74A-RELATED HUMAN|HGNC=26266|UniProtKB=Q6P1R3 Q6P1R3 MSANTD2 PTHR46933:SF1 MYB/SANT-LIKE DNA-BINDING DOMAIN-CONTAINING PROTEIN 2 MYB_SANT-LIKE DNA-BINDING DOMAIN-CONTAINING PROTEIN 2 HUMAN|HGNC=20083|UniProtKB=Q86TM3 Q86TM3 DDX53 PTHR47958:SF50 ATP-DEPENDENT RNA HELICASE DBP3 ATP-DEPENDENT RNA HELICASE DDX53-RELATED ATP-dependent activity#GO:0140657;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723;macromolecular conformation isomerase activity#GO:0120543;RNA helicase activity#GO:0003724;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;isomerase activity#GO:0016853;catalytic activity, acting on RNA#GO:0140098;helicase activity#GO:0004386 RNA helicase#PC00032 HUMAN|HGNC=16175|UniProtKB=Q2I0M5 Q2I0M5 RSPO4 PTHR46987:SF6 NEUROHYPOPHYSIAL HORMONES, N-TERMINAL DOMAIN CONTAINING PROTEIN R-SPONDIN-4 protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488 positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;positive regulation of canonical Wnt signaling pathway#GO:0090263;regulation of response to stimulus#GO:0048583;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of response to stimulus#GO:0048584;positive regulation of Wnt signaling pathway#GO:0030177;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of canonical Wnt signaling pathway#GO:0060828 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=2071|UniProtKB=P49761 P49761 CLK3 PTHR45646:SF10 SERINE/THREONINE-PROTEIN KINASE DOA-RELATED DUAL SPECIFICITY PROTEIN KINASE CLK3 transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein tyrosine kinase activity#GO:0004713;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=823|UniProtKB=P25705 P25705 ATP5F1A PTHR48082:SF3 ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL ATP SYNTHASE F(1) COMPLEX SUBUNIT ALPHA, MITOCHONDRIAL proton channel activity#GO:0015252;nucleotide binding#GO:0000166;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;catalytic activity#GO:0003824;passive transmembrane transporter activity#GO:0022803;channel activity#GO:0015267;anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167;heterocyclic compound binding#GO:1901363;monoatomic ion transmembrane transporter activity#GO:0015075;purine ribonucleotide binding#GO:0032555;monoatomic ion channel activity#GO:0005216;ribonucleotide binding#GO:0032553;ligase activity#GO:0016874;transporter activity#GO:0005215;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;proton transmembrane transporter activity#GO:0015078;carbohydrate derivative binding#GO:0097367;monoatomic cation transmembrane transporter activity#GO:0008324;proton-transporting ATP synthase activity, rotational mechanism#GO:0046933;ATP binding#GO:0005524;binding#GO:0005488;nucleoside phosphate binding#GO:1901265 purine nucleoside triphosphate biosynthetic process#GO:0009145;nucleoside triphosphate metabolic process#GO:0009141;nucleoside phosphate metabolic process#GO:0006753;proton motive force-driven ATP synthesis#GO:0015986;primary metabolic process#GO:0044238;purine nucleoside triphosphate metabolic process#GO:0009144;organophosphate biosynthetic process#GO:0090407;purine ribonucleoside triphosphate biosynthetic process#GO:0009206;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;nucleoside triphosphate biosynthetic process#GO:0009142;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;purine ribonucleoside triphosphate metabolic process#GO:0009205;carbohydrate derivative metabolic process#GO:1901135;nucleoside phosphate biosynthetic process#GO:1901293;small molecule metabolic process#GO:0044281;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide biosynthetic process#GO:0009165;ribonucleotide metabolic process#GO:0009259;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;ribose phosphate biosynthetic process#GO:0046390;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;ribonucleoside triphosphate biosynthetic process#GO:0009201;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;ATP biosynthetic process#GO:0006754 catalytic complex#GO:1902494;cation channel complex#GO:0034703;proton-transporting two-sector ATPase complex#GO:0016469;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;respiratory chain complex#GO:0098803;membrane protein complex#GO:0098796;membrane#GO:0016020;proton-transporting ATP synthase complex#GO:0045259;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 primary active transporter#PC00068;ATP synthase#PC00002 ATP synthesis#P02721>F1 alpha#P02791 HUMAN|HGNC=14035|UniProtKB=Q9BYC8 Q9BYC8 MRPL32 PTHR21026:SF2 39S RIBOSOMAL PROTEIN L32, MITOCHONDRIAL LARGE RIBOSOMAL SUBUNIT PROTEIN BL32M structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 translation#GO:0006412;metabolic process#GO:0008152;mitochondrial gene expression#GO:0140053;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;gene expression#GO:0010467;mitochondrial translation#GO:0032543;protein biosynthetic process#GO:0160307 mitochondrial large ribosomal subunit#GO:0005762;membraneless organelle#GO:0043228;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;membrane-enclosed lumen#GO:0031974;membrane-bounded organelle#GO:0043227;mitochondrial ribosome#GO:0005761;intracellular anatomical structure#GO:0005622;organellar ribosome#GO:0000313;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;large ribosomal subunit#GO:0015934;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;mitochondrion#GO:0005739;ribosome#GO:0005840 ribosomal protein#PC00202 HUMAN|HGNC=15598|UniProtKB=P81172 P81172 HAMP PTHR16877:SF0 HEPCIDIN HEPCIDIN transporter regulator activity#GO:0141108;molecular function activator activity#GO:0140677;hormone activity#GO:0005179;molecular function inhibitor activity#GO:0140678;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546 response to bacterium#GO:0009617;defense response to bacterium#GO:0042742;inorganic ion homeostasis#GO:0098771;intracellular monoatomic ion homeostasis#GO:0006873;defense response to Gram-positive bacterium#GO:0050830;response to stimulus#GO:0050896;intracellular iron ion homeostasis#GO:0006879;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;homeostatic process#GO:0042592;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;response to external stimulus#GO:0009605;intracellular chemical homeostasis#GO:0055082;defense response#GO:0006952;cellular homeostasis#GO:0019725;multicellular organismal-level homeostasis#GO:0048871;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;monoatomic ion homeostasis#GO:0050801;multicellular organismal process#GO:0032501;response to other organism#GO:0051707 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=1859|UniProtKB=Q9BV73 Q9BV73 CEP250 PTHR23159:SF1 CENTROSOMAL PROTEIN 2 CENTROSOME-ASSOCIATED PROTEIN CEP250 cilium organization#GO:0044782;cellular component organization or biogenesis#GO:0071840;organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031;plasma membrane bounded cell projection organization#GO:0120036;cell projection organization#GO:0030030;cellular component assembly#GO:0022607;cellular process#GO:0009987;cell projection assembly#GO:0030031;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996 microtubule organizing center#GO:0005815;centrosome#GO:0005813;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;microtubule cytoskeleton#GO:0015630;organelle#GO:0043226;cellular anatomical structure#GO:0110165;centriole#GO:0005814;intracellular membraneless organelle#GO:0043232 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=1190|UniProtKB=Q9NZP6 Q9NZP6 NPAP1 PTHR23193:SF15 NUCLEAR PORE COMPLEX PROTEIN NUP NUCLEAR PORE-ASSOCIATED PROTEIN 1 structural constituent of nuclear pore#GO:0017056;structural molecule activity#GO:0005198;molecular carrier activity#GO:0140104;nucleocytoplasmic carrier activity#GO:0140142 nucleocytoplasmic transport#GO:0006913;nuclear transport#GO:0051169;protein import into nucleus#GO:0006606;nuclear export#GO:0051168;protein transport#GO:0015031;localization#GO:0051179;cellular localization#GO:0051641;nucleic acid transport#GO:0050657;establishment of RNA localization#GO:0051236;nucleobase-containing compound transport#GO:0015931;protein localization to organelle#GO:0033365;RNA transport#GO:0050658;RNA localization#GO:0006403;intracellular protein transport#GO:0006886;transport#GO:0006810;RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule localization#GO:0033036;import into nucleus#GO:0051170;nitrogen compound transport#GO:0071705;protein localization to nucleus#GO:0034504 intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;nuclear pore#GO:0005643;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle envelope#GO:0031967;nucleus#GO:0005634;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635 transporter#PC00227 HUMAN|HGNC=8380|UniProtKB=Q8NG98 Q8NG98 OR7D4 PTHR48001:SF138 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 7D4 transmembrane signal receptor#PC00197 HUMAN|HGNC=8740|UniProtKB=Q9HD42 Q9HD42 CHMP1A PTHR10476:SF17 CHARGED MULTIVESICULAR BODY PROTEIN CHARGED MULTIVESICULAR BODY PROTEIN 1A late endosome to vacuole transport#GO:0045324;localization#GO:0051179;cellular localization#GO:0051641;protein transport#GO:0015031;macromolecule localization#GO:0033036;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;multivesicular body sorting pathway#GO:0071985;endosome transport via multivesicular body sorting pathway#GO:0032509;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;vacuolar transport#GO:0007034;transport#GO:0006810;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;endosomal transport#GO:0016197 endosome#GO:0005768;endosome membrane#GO:0010008;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane#GO:0016020;vesicle membrane#GO:0012506;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;late endosome#GO:0005770;endomembrane system#GO:0012505;cytoplasm#GO:0005737 membrane traffic protein#PC00150 HUMAN|HGNC=1982|UniProtKB=Q14011 Q14011 CIRBP PTHR48034:SF5 TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED COLD-INDUCIBLE RNA-BINDING PROTEIN RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729 RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 nucleus#GO:0005634;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 RNA metabolism protein#PC00031 HUMAN|HGNC=19353|UniProtKB=Q96ST3 Q96ST3 SIN3A PTHR12346:SF2 SIN3B-RELATED PAIRED AMPHIPATHIC HELIX PROTEIN SIN3A transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714 negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of metabolic process#GO:0009892;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 nucleus#GO:0005634;chromatin#GO:0000785;membrane-enclosed lumen#GO:0031974;histone deacetylase complex#GO:0000118;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;chromosome#GO:0005694;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;Sin3-type complex#GO:0070822;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 chromatin/chromatin-binding, or -regulatory protein#PC00077 Huntington disease#P00029>Sin3A#P00771;p53 pathway#P00059>Sin3#P04622 HUMAN|HGNC=29962|UniProtKB=Q5JRC9 Q5JRC9 FAM47A PTHR47415:SF4 PROTEIN FAM47B PROTEIN FAM47A HUMAN|HGNC=3973|UniProtKB=O95633 O95633 FSTL3 PTHR10913:SF16 FOLLISTATIN-RELATED FOLLISTATIN-RELATED PROTEIN 3 binding#GO:0005488;activin binding#GO:0048185;protein-containing complex binding#GO:0044877 cellular developmental process#GO:0048869;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;developmental process#GO:0032502;negative regulation of response to stimulus#GO:0048585;negative regulation of signal transduction#GO:0009968;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cellular response to growth factor stimulus#GO:0090287;regulation of BMP signaling pathway#GO:0030510;cellular process#GO:0009987;negative regulation of cell communication#GO:0010648;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of cell communication#GO:0010646;negative regulation of biological process#GO:0048519;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HUMAN|HGNC=13136|UniProtKB=Q15940 Q15940 ZNF726P1 PTHR24377:SF912 IP01015P-RELATED ZINC FINGER PROTEIN 254-RELATED RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=16312|UniProtKB=Q8N743 Q8N743 KIR3DL3 PTHR11738:SF177 MHC CLASS I NK CELL RECEPTOR KILLER CELL IMMUNOGLOBULIN-LIKE RECEPTOR 3DL3 transmembrane signaling receptor activity#GO:0004888;immune receptor activity#GO:0140375;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 immune response-regulating cell surface receptor signaling pathway#GO:0002768;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;immune response-regulating signaling pathway#GO:0002764;cell communication#GO:0007154;regulation of immune response#GO:0050776;cell surface receptor signaling pathway#GO:0007166;regulation of response to stimulus#GO:0048583 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=10786|UniProtKB=Q08170 Q08170 SRSF4 PTHR23147:SF292 SERINE/ARGININE RICH SPLICING FACTOR SERINE_ARGININE-RICH SPLICING FACTOR 4 organelle lumen#GO:0043233;nuclear speck#GO:0016607;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;nuclear body#GO:0016604;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228 RNA splicing factor#PC00148;RNA metabolism protein#PC00031;RNA processing factor#PC00147 HUMAN|HGNC=10863|UniProtKB=Q16842 Q16842 ST3GAL2 PTHR46032:SF4 ALPHA-2,3-SIALYLTRANSFERASE ST3GAL I ISOFORM X1 CMP-N-ACETYLNEURAMINATE-BETA-GALACTOSAMIDE-ALPHA-2,3-SIALYLTRANSFERASE 2 catalytic activity#GO:0003824;transferase activity#GO:0016740;sialyltransferase activity#GO:0008373;glycosyltransferase activity#GO:0016757 biosynthetic process#GO:0009058;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;macromolecule modification#GO:0043412;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152 membrane#GO:0016020;cellular anatomical structure#GO:0110165 transferase#PC00220 HUMAN|HGNC=17850|UniProtKB=Q9BQA5 Q9BQA5 HINFP PTHR24391:SF26 HISTONE H4 TRANSCRIPTION FACTOR-RELATED HISTONE H4 TRANSCRIPTION FACTOR sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=13050|UniProtKB=O95789 O95789 ZMYM6 PTHR45736:SF9 ZINC FINGER MYM-TYPE PROTEIN ZINC FINGER MYM-TYPE PROTEIN 6 DNA-binding transcription factor#PC00218;zinc finger transcription factor#PC00244 HUMAN|HGNC=33920|UniProtKB=Q6IEE8 Q6IEE8 SLFN12L PTHR12155:SF46 SCHLAFEN SCHLAFEN FAMILY MEMBER 12-LIKE endoribonuclease#PC00094 HUMAN|HGNC=29396|UniProtKB=Q5R3F8 Q5R3F8 ELFN2 PTHR24373:SF263 SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 29 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 signaling#GO:0023052;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;anterograde trans-synaptic signaling#GO:0098916;regulation of biological process#GO:0050789;cellular process#GO:0009987;chemical synaptic transmission#GO:0007268;synaptic signaling#GO:0099536;cell communication#GO:0007154;trans-synaptic signaling#GO:0099537 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=24812|UniProtKB=Q5HYI7 Q5HYI7 MTX3 PTHR12289:SF30 METAXIN RELATED METAXIN-3 localization#GO:0051179;cellular localization#GO:0051641;protein insertion into mitochondrial outer membrane#GO:0045040;localization within membrane#GO:0051668;protein localization to organelle#GO:0033365;protein-containing complex assembly#GO:0065003;protein localization to mitochondrion#GO:0070585;cellular component organization#GO:0016043;intracellular protein localization#GO:0008104;protein-containing complex organization#GO:0043933;establishment of protein localization to organelle#GO:0072594;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;mitochondrion organization#GO:0007005;membrane organization#GO:0061024;protein insertion into membrane#GO:0051205;cellular component assembly#GO:0022607;mitochondrial membrane organization#GO:0007006;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;establishment of protein localization to membrane#GO:0090150;organelle organization#GO:0006996;macromolecule localization#GO:0033036 outer membrane#GO:0019867;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;membrane protein complex#GO:0098796;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrial outer membrane translocase complex#GO:0005742;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;mitochondrial outer membrane#GO:0005741;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;membrane#GO:0016020;cytoplasm#GO:0005737;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;organelle outer membrane#GO:0031968 transporter#PC00227 HUMAN|HGNC=13617|UniProtKB=Q8NCQ5 Q8NCQ5 FBXO15 PTHR46731:SF1 F-BOX ONLY PROTEIN 15 F-BOX ONLY PROTEIN 15 protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;cullin-RING ubiquitin ligase complex#GO:0031461;SCF ubiquitin ligase complex#GO:0019005;intracellular protein-containing complex#GO:0140535;catalytic complex#GO:1902494;transferase complex#GO:1990234 HUMAN|HGNC=9850|UniProtKB=Q9H6Z4 Q9H6Z4 RANBP3 PTHR23138:SF91 RAN BINDING PROTEIN RAN-BINDING PROTEIN 3 nuclear transport#GO:0051169;protein transport#GO:0015031;nuclear export#GO:0051168;localization#GO:0051179;cellular localization#GO:0051641;nucleocytoplasmic transport#GO:0006913;protein export from nucleus#GO:0006611;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule localization#GO:0033036;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907 nucleus#GO:0005634;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular organelle#GO:0043229;nuclear pore#GO:0005643;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 scaffold/adaptor protein#PC00226 HUMAN|HGNC=987|UniProtKB=P21953 P21953 BCKDHB PTHR42980:SF1 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL protein-containing complex#GO:0032991;oxidoreductase complex#GO:1990204;catalytic complex#GO:1902494;transferase complex#GO:1990234 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=3606|UniProtKB=P09467 P09467 FBP1 PTHR11556:SF11 FRUCTOSE-1,6-BISPHOSPHATASE-RELATED FRUCTOSE-1,6-BISPHOSPHATASE 1 phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;sugar-phosphatase activity#GO:0050308;phosphatase activity#GO:0016791;catalytic activity#GO:0003824 glucose metabolic process#GO:0006006;metabolic process#GO:0008152;monosaccharide metabolic process#GO:0005996;small molecule biosynthetic process#GO:0044283;small molecule metabolic process#GO:0044281;biosynthetic process#GO:0009058;carbohydrate metabolic process#GO:0005975;monosaccharide biosynthetic process#GO:0046364;carbohydrate biosynthetic process#GO:0016051;primary metabolic process#GO:0044238;hexose metabolic process#GO:0019318;hexose biosynthetic process#GO:0019319;gluconeogenesis#GO:0006094;cellular process#GO:0009987 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 carbohydrate phosphatase#PC00066;hydrolase#PC00121;phosphatase#PC00181 HUMAN|HGNC=17264|UniProtKB=O95602 O95602 POLR1A PTHR19376:SF11 DNA-DIRECTED RNA POLYMERASE DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1 nucleolar large rRNA transcription by RNA polymerase I#GO:0042790;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;transcription by RNA polymerase I#GO:0006360;rRNA transcription#GO:0009303;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187 intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;transferase complex#GO:1990234;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;membrane-bounded organelle#GO:0043227;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;RNA polymerase I complex#GO:0005736;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;nucleolus#GO:0005730;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle lumen#GO:0043233 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 HUMAN|HGNC=29558|UniProtKB=Q9H093 Q9H093 NUAK2 PTHR24343:SF133 SERINE/THREONINE KINASE NUAK FAMILY SNF1-LIKE KINASE 2 protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 cellular response to starvation#GO:0009267;cellular response to stress#GO:0033554;cellular response to nutrient levels#GO:0031669;response to stress#GO:0006950;response to starvation#GO:0042594;response to nutrient levels#GO:0031667;cellular response to glucose starvation#GO:0042149;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=9395|UniProtKB=P05771 P05771 PRKCB PTHR24356:SF158 SERINE/THREONINE-PROTEIN KINASE PROTEIN KINASE C BETA TYPE protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 non-receptor serine/threonine protein kinase#PC00167 Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>PKC#P01074;Gonadotropin-releasing hormone receptor pathway#P06664>PKCs#P06733;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>PKC#P00745;Alzheimer disease-amyloid secretase pathway#P00003>PKC#P00109;5HT2 type receptor mediated signaling pathway#P04374>PKC#P04420;Metabotropic glutamate receptor group I pathway#P00041>PKC#P01055;Apoptosis signaling pathway#P00006>PKCs#P00318;Oxytocin receptor mediated signaling pathway#P04391>PKC#P04533;Wnt signaling pathway#P00057>Protein Kinase C#P01458;B cell activation#P00010>PKC#P00373;Thyrotropin-releasing hormone receptor signaling pathway#P04394>PKC#P04583;FGF signaling pathway#P00021>PKC#P00648;Endothelin signaling pathway#P00019>PKC#P00568;VEGF signaling pathway#P00056>PKC#P01425;Angiogenesis#P00005>PKC#P00219;CCKR signaling map#P06959>PKCbeta#P07177;Histamine H1 receptor mediated signaling pathway#P04385>PKC#P04487;EGF receptor signaling pathway#P00018>PKC#P00565;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PKC#P00861 HUMAN|HGNC=11303|UniProtKB=O76094 O76094 SRP72 PTHR14094:SF9 SIGNAL RECOGNITION PARTICLE 72 SIGNAL RECOGNITION PARTICLE SUBUNIT SRP72 nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723;ribonucleoprotein complex binding#GO:0043021;ribosome binding#GO:0043022;protein-containing complex binding#GO:0044877 establishment of protein localization to membrane#GO:0090150;establishment of protein localization#GO:0045184;cellular process#GO:0009987;protein targeting#GO:0006605;establishment of protein localization to endoplasmic reticulum#GO:0072599;protein targeting to membrane#GO:0006612;localization within membrane#GO:0051668;SRP-dependent cotranslational protein targeting to membrane#GO:0006614;establishment of protein localization to organelle#GO:0072594;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;protein targeting to ER#GO:0045047 intracellular anatomical structure#GO:0005622;signal recognition particle, endoplasmic reticulum targeting#GO:0005786;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;ribonucleoprotein complex#GO:1990904 HUMAN|HGNC=10920|UniProtKB=P46059 P46059 SLC15A1 PTHR11654:SF89 OLIGOPEPTIDE TRANSPORTER-RELATED SOLUTE CARRIER FAMILY 15 MEMBER 1 oligopeptide transmembrane transporter activity#GO:0035673;dipeptide transmembrane transporter activity#GO:0071916;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 import across plasma membrane#GO:0098739;peptide transport#GO:0015833;nitrogen compound transport#GO:0071705;oligopeptide transmembrane transport#GO:0035672;cellular process#GO:0009987;localization#GO:0051179;transmembrane transport#GO:0055085;import into cell#GO:0098657;dipeptide transport#GO:0042938;establishment of localization#GO:0051234;oligopeptide transport#GO:0006857;transport#GO:0006810 plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;apical plasma membrane#GO:0016324;membrane#GO:0016020;apical part of cell#GO:0045177;cell periphery#GO:0071944 transporter#PC00227 HUMAN|HGNC=28547|UniProtKB=Q8N0U7 Q8N0U7 C1orf87 PTHR34830:SF1 SIMILAR TO HYPOTHETICAL PROTEIN MGC34837 SIMILAR TO HUMAN CHROMOSOME 1 OPEN READING FRAME 87 HUMAN|HGNC=28089|UniProtKB=Q8TE69 Q8TE69 EOLA1 PTHR31666:SF0 PROTEIN CXORF40A-RELATED PROTEIN EOLA1-RELATED HUMAN|HGNC=13963|UniProtKB=Q9UGF7 Q9UGF7 OR12D3 PTHR26451:SF819 G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN OLFACTORY RECEPTOR 12D3 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;binding#GO:0005488 detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;nervous system process#GO:0050877;sensory perception#GO:0007600;system process#GO:0003008;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;detection of chemical stimulus#GO:0009593;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;response to stimulus#GO:0050896;response to chemical#GO:0042221 membrane#GO:0016020;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021 HUMAN|HGNC=189|UniProtKB=O75078 O75078 ADAM11 PTHR11905:SF114 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 11 catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metalloendopeptidase activity#GO:0004222;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;cellular process#GO:0009987;proteolysis#GO:0006508;metabolic process#GO:0008152;primary metabolic process#GO:0044238 cell junction#GO:0030054;synaptic membrane#GO:0097060;synapse#GO:0045202;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;presynaptic membrane#GO:0042734;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;presynapse#GO:0098793 metalloprotease#PC00153;protease#PC00190 HUMAN|HGNC=27004|UniProtKB=Q5VZ18 Q5VZ18 SHE PTHR15127:SF29 HEAVYWEIGHT, ISOFORM A SH2 DOMAIN-CONTAINING ADAPTER PROTEIN E binding#GO:0005488;protein binding#GO:0005515 HUMAN|HGNC=30654|UniProtKB=Q8IZH2 Q8IZH2 XRN1 PTHR12341:SF7 5'->3' EXORIBONUCLEASE 5'-3' EXORIBONUCLEASE 1 binding#GO:0005488;nucleic acid binding#GO:0003676;exonuclease activity#GO:0004527;5'-3' exonuclease activity#GO:0008409;nuclease activity#GO:0004518;RNA binding#GO:0003723;hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on RNA#GO:0140098;RNA nuclease activity#GO:0004540 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleobase-containing compound catabolic process#GO:0034655;mRNA catabolic process#GO:0006402;nucleic acid catabolic process#GO:0141188;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;negative regulation of cellular process#GO:0048523;macromolecule catabolic process#GO:0009057;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;macromolecule metabolic process#GO:0043170;regulation of gene expression#GO:0010468;nucleic acid metabolic process#GO:0090304;negative regulation of gene expression#GO:0010629;primary metabolic process#GO:0044238;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;RNA catabolic process#GO:0006401;RNA metabolic process#GO:0016070 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 RNA metabolism protein#PC00031;exoribonuclease#PC00099 DNA replication#P00017>5' to 3' Exoribonulcease#P00535 HUMAN|HGNC=29335|UniProtKB=Q3SXP7 Q3SXP7 SHISAL1 PTHR31395:SF11 SHISA PROTEIN SHISA-LIKE-1 scaffold/adaptor protein#PC00226 HUMAN|HGNC=5948|UniProtKB=Q8N6C5 Q8N6C5 IGSF1 PTHR11738:SF163 MHC CLASS I NK CELL RECEPTOR IMMUNOGLOBULIN SUPERFAMILY MEMBER 1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=23445|UniProtKB=A6NNL0 A6NNL0 NUTM2B PTHR22879:SF14 NUT FAMILY MEMBER 1 NUT FAMILY MEMBER 2A-RELATED HUMAN|HGNC=21906|UniProtKB=Q9NX63 Q9NX63 CHCHD3 PTHR21588:SF22 COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 6 MICOS COMPLEX SUBUNIT MIC19 cellular process#GO:0009987;inner mitochondrial membrane organization#GO:0007007;mitochondrial membrane organization#GO:0007006;cellular component organization#GO:0016043;organelle organization#GO:0006996;mitochondrion organization#GO:0007005;membrane organization#GO:0061024;cellular component organization or biogenesis#GO:0071840 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane protein complex#GO:0098796;organelle envelope#GO:0031967;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;inner mitochondrial membrane protein complex#GO:0098800;organelle membrane#GO:0031090;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrial membrane#GO:0031966;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;cytoplasm#GO:0005737 HUMAN|HGNC=16719|UniProtKB=Q14147 Q14147 DHX34 PTHR18934:SF278 ATP-DEPENDENT RNA HELICASE ATP-DEPENDENT RNA HELICASE DHX34-RELATED macromolecular conformation isomerase activity#GO:0120543;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;isomerase activity#GO:0016853;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;negative regulation of biological process#GO:0048519;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;RNA metabolic process#GO:0016070;RNA catabolic process#GO:0006401;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleobase-containing compound catabolic process#GO:0034655;mRNA catabolic process#GO:0006402;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;nucleic acid catabolic process#GO:0141188;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of gene expression#GO:0010468;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;negative regulation of cellular process#GO:0048523;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay#GO:0000184 RNA helicase#PC00032;RNA metabolism protein#PC00031 HUMAN|HGNC=3520|UniProtKB=O00167 O00167 EYA2 PTHR10190:SF7 EYES ABSENT PROTEIN PHOSPHATASE EYA2 catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725;phosphoprotein phosphatase activity#GO:0004721 positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of response to stimulus#GO:0048584;positive regulation of DNA repair#GO:0045739;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular developmental process#GO:0048869;regulation of response to stress#GO:0080134;regulation of DNA repair#GO:0006282;regulation of response to stimulus#GO:0048583;developmental process#GO:0032502;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;positive regulation of DNA metabolic process#GO:0051054;regulation of DNA metabolic process#GO:0051052;regulation of biological process#GO:0050789;positive regulation of metabolic process#GO:0009893;regulation of cellular response to stress#GO:0080135 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 histone modifying enzyme#PC00261 HUMAN|HGNC=18237|UniProtKB=Q8TCZ2 Q8TCZ2 CD99L2 PTHR15076:SF12 CD99/MIC2 PROTEIN RELATED CD99 ANTIGEN-LIKE PROTEIN 2 HUMAN|HGNC=27717|UniProtKB=Q96FX2 Q96FX2 DPH3 PTHR21454:SF24 DPH3 HOMOLOG-RELATED DIPHTHAMIDE BIOSYNTHESIS PROTEIN 3 small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;transition metal ion binding#GO:0046914;iron ion binding#GO:0005506;metal ion binding#GO:0046872;cation binding#GO:0043169 protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein modification process#GO:0036211;primary metabolic process#GO:0044238;metabolic process#GO:0008152;cellular process#GO:0009987 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=14456|UniProtKB=Q9BTM1 Q9BTM1 H2AJ PTHR23430:SF355 HISTONE H2A HISTONE H2A.J structural molecule activity#GO:0005198 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;heterochromatin formation#GO:0031507;regulation of biological process#GO:0050789;cellular component assembly#GO:0022607;heterochromatin organization#GO:0070828;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of macromolecule biosynthetic process#GO:0010556;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of gene expression, epigenetic#GO:0045814;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular membraneless organelle#GO:0043232;nucleosome#GO:0000786;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-DNA complex#GO:0032993;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=12567|UniProtKB=Q6ZN44 Q6ZN44 UNC5A PTHR12582:SF4 NETRIN RECEPTOR UNC5 NETRIN RECEPTOR UNC5A molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell development#GO:0048468;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;anatomical structure development#GO:0048856;axonogenesis#GO:0007409;neuron development#GO:0048666;system development#GO:0048731;axon development#GO:0061564;axon guidance#GO:0007411;neuron projection development#GO:0031175;cellular process#GO:0009987;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cell morphogenesis involved in neuron differentiation#GO:0048667;neuron projection morphogenesis#GO:0048812;plasma membrane bounded cell projection morphogenesis#GO:0120039;developmental process#GO:0032502;neuron differentiation#GO:0030182;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;neurogenesis#GO:0022008;cell projection morphogenesis#GO:0048858;neuron projection guidance#GO:0097485 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 Axon guidance mediated by netrin#P00009>UNC-5#P00356 HUMAN|HGNC=19423|UniProtKB=Q9UNL4 Q9UNL4 ING4 PTHR10333:SF106 INHIBITOR OF GROWTH PROTEIN INHIBITOR OF GROWTH PROTEIN 4 chromatin-protein adaptor activity#GO:0140463;histone reader activity#GO:0140566;protein-macromolecule adaptor activity#GO:0030674;histone H3 reader activity#GO:0140006;molecular adaptor activity#GO:0060090 positive regulation of apoptotic process#GO:0043065;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of apoptotic process#GO:0042981;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;chromatin organization#GO:0006325;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;positive regulation of programmed cell death#GO:0043068;regulation of cellular process#GO:0050794;regulation of programmed cell death#GO:0043067;cellular component organization#GO:0016043;regulation of biological process#GO:0050789 chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;protein acetyltransferase complex#GO:0031248;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;acetyltransferase complex#GO:1902493;chromatin#GO:0000785;nucleus#GO:0005634;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;histone acetyltransferase complex#GO:0000123;membraneless organelle#GO:0043228 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=10908|UniProtKB=P49281 P49281 SLC11A2 PTHR11706:SF40 SOLUTE CARRIER PROTEIN FAMILY 11 MEMBER NATURAL RESISTANCE-ASSOCIATED MACROPHAGE PROTEIN 2 monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;metal ion binding#GO:0046872;iron ion transmembrane transporter activity#GO:0005381;cation binding#GO:0043169;monoatomic cation transmembrane transporter activity#GO:0008324;transition metal ion transmembrane transporter activity#GO:0046915;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;transition metal ion binding#GO:0046914 transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;intracellular monoatomic cation homeostasis#GO:0030003;iron ion transmembrane transport#GO:0034755;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;establishment of localization#GO:0051234;cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;transition metal ion transport#GO:0000041;inorganic ion homeostasis#GO:0098771;iron ion transport#GO:0006826;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;intracellular monoatomic ion homeostasis#GO:0006873;homeostatic process#GO:0042592;metal ion transport#GO:0030001;intracellular iron ion homeostasis#GO:0006879 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;lytic vacuole membrane#GO:0098852;lysosome#GO:0005764;vesicle#GO:0031982;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;endosome membrane#GO:0010008;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;plasma membrane#GO:0005886;vacuole#GO:0005773;membrane#GO:0016020;vesicle membrane#GO:0012506;lysosomal membrane#GO:0005765;cell periphery#GO:0071944;vacuolar membrane#GO:0005774;lytic vacuole#GO:0000323;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588 secondary carrier transporter#PC00258;transporter#PC00227 HUMAN|HGNC=16743|UniProtKB=Q6S5L8 Q6S5L8 SHC4 PTHR10337:SF12 SHC TRANSFORMING PROTEIN SHC-TRANSFORMING PROTEIN 4 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 regulation of cell population proliferation#GO:0042127;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;positive regulation of cell population proliferation#GO:0008284;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987 scaffold/adaptor protein#PC00226 HUMAN|HGNC=19844|UniProtKB=Q147X3 Q147X3 NAA30 PTHR45896:SF1 N-ALPHA-ACETYLTRANSFERASE 30 N-ALPHA-ACETYLTRANSFERASE 30 acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;N-acetyltransferase activity#GO:0008080;protein N-acyltransferase activity#GO:0140186;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein-N-terminal amino-acid acetyltransferase activity#GO:0004596;catalytic activity, acting on a protein#GO:0140096;protein N-acetyltransferase activity#GO:0034212;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;protein acetyltransferase complex#GO:0031248;transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;acetyltransferase complex#GO:1902493 transferase#PC00220;acetyltransferase#PC00038;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=20812|UniProtKB=Q9NX65 Q9NX65 ZSCAN32 PTHR23226:SF209 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 32 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=19280|UniProtKB=Q9H7H0 Q9H7H0 METTL17 PTHR21320:SF3 CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11-RELATED RIBOSOME ASSEMBLY PROTEIN METTL17, MITOCHONDRIAL chaperone#PC00072 HUMAN|HGNC=8570|UniProtKB=Q9BY11 Q9BY11 PACSIN1 PTHR23065:SF16 PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1 PROTEIN KINASE C AND CASEIN KINASE SUBSTRATE IN NEURONS PROTEIN 1 lipid binding#GO:0008289;binding#GO:0005488;phospholipid binding#GO:0005543 positive regulation of cellular process#GO:0048522;plasma membrane bounded cell projection organization#GO:0120036;membrane organization#GO:0061024;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;positive regulation of developmental process#GO:0051094;regulation of cell projection organization#GO:0031344;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of developmental process#GO:0050793;regulation of dendrite development#GO:0050773;regulation of cellular process#GO:0050794;positive regulation of cell projection organization#GO:0031346;system development#GO:0048731;anatomical structure development#GO:0048856;cellular process#GO:0009987;regulation of neuron projection development#GO:0010975;positive regulation of biological process#GO:0048518;organelle organization#GO:0006996;neuron projection development#GO:0031175;nervous system development#GO:0007399;cytoskeleton organization#GO:0007010;endomembrane system organization#GO:0010256;plasma membrane bounded cell projection morphogenesis#GO:0120039;regulation of endocytosis#GO:0030100;neuron differentiation#GO:0030182;regulation of localization#GO:0032879;cell projection morphogenesis#GO:0048858;regulation of transport#GO:0051049;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;cell development#GO:0048468;cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;regulation of cellular component organization#GO:0051128;cell differentiation#GO:0030154;generation of neurons#GO:0048699;positive regulation of cellular component organization#GO:0051130;animal gross anatomical part developmental process#GO:0160108;positive regulation of neuron projection development#GO:0010976;neuron development#GO:0048666;plasma membrane organization#GO:0007009 intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;plasma membrane#GO:0005886;membrane#GO:0016020;intracellular vesicle#GO:0097708;cell periphery#GO:0071944;vesicle#GO:0031982 actin or actin-binding cytoskeletal protein#PC00041;cytoskeletal protein#PC00085 Huntington disease#P00029>PACSIN-1#P00802 HUMAN|HGNC=24337|UniProtKB=Q9NS00 Q9NS00 C1GALT1 PTHR23033:SF13 BETA1,3-GALACTOSYLTRANSFERASE GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1 catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758;glycosyltransferase activity#GO:0016757;catalytic activity, acting on a protein#GO:0140096;UDP-glycosyltransferase activity#GO:0008194;galactosyltransferase activity#GO:0008378 transferase#PC00220 HUMAN|HGNC=2217|UniProtKB=P20849 P20849 COL9A1 PTHR24023:SF918 COLLAGEN ALPHA COLLAGEN ALPHA-1(IX) CHAIN structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 cellular process#GO:0009987;extracellular structure organization#GO:0043062;cellular component organization#GO:0016043;external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840 supramolecular complex#GO:0099080;interstitial matrix#GO:0005614;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular protein-containing complex#GO:0140392;extracellular region#GO:0005576 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 Integrin signalling pathway#P00034>Collagen#P00922 HUMAN|HGNC=13406|UniProtKB=Q9Y6V0 Q9Y6V0 PCLO PTHR14113:SF6 PICCOLO/BASSOON PROTEIN PICCOLO structural constituent of synapse#GO:0098918;structural molecule activity#GO:0005198 cell junction organization#GO:0034330;synapse assembly#GO:0007416;cell junction assembly#GO:0034329;cellular component organization#GO:0016043;system development#GO:0048731;localization#GO:0051179;anatomical structure development#GO:0048856;synapse organization#GO:0050808;protein localization to cell junction#GO:1902414;animal gross anatomical part developmental process#GO:0160108;nervous system development#GO:0007399;cellular component assembly#GO:0022607;multicellular organismal process#GO:0032501;cellular process#GO:0009987;macromolecule localization#GO:0033036;cellular component biogenesis#GO:0044085;intracellular protein localization#GO:0008104;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;protein localization to synapse#GO:0035418;developmental process#GO:0032502 intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;glutamatergic synapse#GO:0098978;neuron projection#GO:0043005;presynapse#GO:0098793;cell periphery#GO:0071944;cell junction#GO:0030054;membraneless organelle#GO:0043228;presynaptic active zone#GO:0048786;cytoskeleton#GO:0005856;GABA-ergic synapse#GO:0098982;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;synapse#GO:0045202;cell cortex#GO:0005938;cortical cytoskeleton#GO:0030863;intracellular anatomical structure#GO:0005622;axon#GO:0030424;intracellular organelle#GO:0043229 HUMAN|HGNC=28468|UniProtKB=Q8WV41 Q8WV41 SNX33 PTHR45827:SF3 SORTING NEXIN SORTING NEXIN-33 ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;phosphatidylinositol binding#GO:0035091;anion binding#GO:0043168 cytokinetic process#GO:0032506;cytokinesis#GO:0000910;cellular localization#GO:0051641;cytoskeleton-dependent cytokinesis#GO:0061640;localization#GO:0051179;plasma membrane organization#GO:0007009;cell cycle process#GO:0022402;cell division#GO:0051301;cellular component organization#GO:0016043;cell cycle#GO:0007049;endocytosis#GO:0006897;transport#GO:0006810;membrane invagination#GO:0010324;intracellular transport#GO:0046907;endosomal transport#GO:0016197;import into cell#GO:0098657;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;vesicle-mediated transport#GO:0016192 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;vesicle#GO:0031982;cell periphery#GO:0071944;intracellular vesicle#GO:0097708;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=19979|UniProtKB=Q9HBH5 Q9HBH5 RDH14 PTHR24320:SF285 RETINOL DEHYDROGENASE RETINOL DEHYDROGENASE 14 oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;alcohol dehydrogenase (NADP+) activity#GO:0008106;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;catalytic activity#GO:0003824 organophosphate biosynthetic process#GO:0090407;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;lipid biosynthetic process#GO:0008610;phospholipid biosynthetic process#GO:0008654;biosynthetic process#GO:0009058;phospholipid metabolic process#GO:0006644;organophosphate metabolic process#GO:0019637;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020 oxidoreductase#PC00176;dehydrogenase#PC00092 HUMAN|HGNC=3067|UniProtKB=Q9UNI6 Q9UNI6 DUSP12 PTHR45848:SF4 DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 FAMILY MEMBER DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;protein tyrosine/serine/threonine phosphatase activity#GO:0008138;phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787 protein phosphatase#PC00195 Oxidative stress response#P00046>MKP5#P01131 HUMAN|HGNC=29113|UniProtKB=Q6IC98 Q6IC98 GRAMD4 PTHR37402:SF1 GRAM DOMAIN-CONTAINING PROTEIN 4 GRAM DOMAIN-CONTAINING PROTEIN 4 positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of response to external stimulus#GO:0032101;negative regulation of response to stimulus#GO:0048585;negative regulation of immune system process#GO:0002683;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;regulation of response to stress#GO:0080134;negative regulation of cellular process#GO:0048523;regulation of apoptotic process#GO:0042981;regulation of response to stimulus#GO:0048583;positive regulation of apoptotic process#GO:0043065;regulation of innate immune response#GO:0045088;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;regulation of biological process#GO:0050789;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;positive regulation of programmed cell death#GO:0043068;regulation of response to biotic stimulus#GO:0002831;regulation of cell communication#GO:0010646;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;regulation of immune response#GO:0050776;regulation of defense response#GO:0031347;regulation of signaling#GO:0023051;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=16497|UniProtKB=Q9NRQ2 Q9NRQ2 PLSCR4 PTHR23248:SF28 PHOSPHOLIPID SCRAMBLASE-RELATED PHOSPHOLIPID SCRAMBLASE 4 lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104;phospholipid scramblase activity#GO:0017128;transporter activity#GO:0005215;intramembrane lipid carrier activity#GO:0140303 regulation of biological quality#GO:0065008;plasma membrane organization#GO:0007009;localization#GO:0051179;lipid localization#GO:0010876;lipid translocation#GO:0034204;plasma membrane phospholipid scrambling#GO:0017121;organophosphate ester transport#GO:0015748;cellular component organization#GO:0016043;regulation of membrane lipid distribution#GO:0097035;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;transport#GO:0006810;phospholipid translocation#GO:0045332;membrane organization#GO:0061024;phospholipid transport#GO:0015914;endomembrane system organization#GO:0010256;biological regulation#GO:0065007;lipid transport#GO:0006869;cellular process#GO:0009987;macromolecule localization#GO:0033036 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227 HUMAN|HGNC=17936|UniProtKB=Q9NZ53 Q9NZ53 PODXL2 PTHR15594:SF1 PODOCALYXIN-LIKE PROTEIN 2 PODOCALYXIN-LIKE PROTEIN 2 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=20220|UniProtKB=Q9Y324 Q9Y324 FCF1 PTHR12416:SF8 RRNA-PROCESSING PROTEIN UTP23 HOMOLOG RRNA-PROCESSING PROTEIN FCF1 HOMOLOG endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000447;ribosomal small subunit biogenesis#GO:0042274;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000472;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000479;cellular component biogenesis#GO:0044085;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;maturation of SSU-rRNA#GO:0030490;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;ribonucleoprotein complex biogenesis#GO:0022613;maturation of 5.8S rRNA#GO:0000460;RNA biosynthetic process#GO:0032774 preribosome#GO:0030684;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;small-subunit processome#GO:0032040;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232 HUMAN|HGNC=33609|UniProtKB=A6NNE9 A6NNE9 MARCHF11 PTHR46053:SF1 E3 UBIQUITIN-PROTEIN LIGASE MARCH4-LIKE E3 UBIQUITIN-PROTEIN LIGASE MARCHF11 acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;ubiquitin-protein transferase activity#GO:0004842 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=34336|UniProtKB=A6NC97 A6NC97 ARB2BP PTHR21357:SF2 FAM172 FAMILY PROTEIN HOMOLOG CG10038 PROTEIN ARB2BP-RELATED binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;heterochromatin formation#GO:0031507;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;regulatory ncRNA-mediated heterochromatin formation#GO:0031048;biological regulation#GO:0065007;chromatin organization#GO:0006325;negative regulation of biosynthetic process#GO:0009890;heterochromatin organization#GO:0070828;cellular component assembly#GO:0022607;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;epigenetic regulation of gene expression#GO:0040029;regulation of gene expression#GO:0010468;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;negative regulation of gene expression, epigenetic#GO:0045814;regulatory ncRNA-mediated gene silencing#GO:0031047;negative regulation of cellular process#GO:0048523 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=16835|UniProtKB=Q9UL54 Q9UL54 TAOK2 PTHR47167:SF6 SERINE/THREONINE-PROTEIN KINASE TAO1-LIKE PROTEIN SERINE_THREONINE-PROTEIN KINASE TAO2 protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096 positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of response to stress#GO:0080134;regulation of response to stimulus#GO:0048583;regulation of MAPK cascade#GO:0043408;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of MAPK cascade#GO:0043410;regulation of JNK cascade#GO:0046328;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of cell communication#GO:0010646;positive regulation of JNK cascade#GO:0046330;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;regulation of cellular response to stress#GO:0080135 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=24837|UniProtKB=Q9UK00 Q9UK00 C3orf18 PTHR15868:SF0 SIMILAR TO RIKEN CDNA 6430571L13 GENE, SIMILAR TO G20 PROTEIN SIMILAR TO HUMAN CHROMOSOME 3 OPEN READING FRAME 18 HUMAN|HGNC=13757|UniProtKB=Q9HDB9 Q9HDB9 ERVK-5 PTHR40389:SF2 ENDOGENOUS RETROVIRUS GROUP K MEMBER 24 GAG POLYPROTEIN-RELATED ENDOGENOUS RETROVIRUS GROUP K MEMBER 24 GAG POLYPROTEIN-RELATED HUMAN|HGNC=31859|UniProtKB=Q6ZTA4 Q6ZTA4 TRIM67 PTHR24099:SF21 E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED TRIPARTITE MOTIF-CONTAINING PROTEIN 67 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=6898|UniProtKB=P56192 P56192 MARS1 PTHR45765:SF1 METHIONINE--TRNA LIGASE METHIONINE--TRNA LIGASE, CYTOPLASMIC catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a tRNA#GO:0140101;ligase activity#GO:0016874;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640 gene expression#GO:0010467;amino acid metabolic process#GO:0006520;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;tRNA aminoacylation#GO:0043039;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;tRNA aminoacylation for protein translation#GO:0006418;amino acid activation#GO:0043038;macromolecule metabolic process#GO:0043170;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;protein biosynthetic process#GO:0160307;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA metabolic process#GO:0016070;protein metabolic process#GO:0019538;translation#GO:0006412 catalytic complex#GO:1902494;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 translational protein#PC00263;aminoacyl-tRNA synthetase#PC00047 HUMAN|HGNC=25979|UniProtKB=Q9NQG6 Q9NQG6 MIEF1 PTHR16451:SF12 MITOCHONDRIAL DYNAMICS PROTEINS 49/51 FAMILY MEMBER MITOCHONDRIAL DYNAMICS PROTEIN MIEF1 regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of mitochondrial fission#GO:0090140;regulation of developmental process#GO:0050793;positive regulation of mitochondrial fission#GO:0090141;regulation of mitochondrion organization#GO:0010821;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;positive regulation of biological process#GO:0048518;regulation of organelle organization#GO:0033043;positive regulation of organelle organization#GO:0010638;regulation of anatomical structure morphogenesis#GO:0022603;positive regulation of developmental process#GO:0051094;positive regulation of cellular component organization#GO:0051130 membrane#GO:0016020;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;organelle outer membrane#GO:0031968;cytoplasm#GO:0005737;mitochondrial outer membrane#GO:0005741;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;organelle envelope#GO:0031967;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;outer membrane#GO:0019867;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=9155|UniProtKB=P16233 P16233 PNLIP PTHR11610:SF147 LIPASE PANCREATIC TRIACYLGLYCEROL LIPASE hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;lipase activity#GO:0016298;catalytic activity#GO:0003824 primary metabolic process#GO:0044238;metabolic process#GO:0008152;cellular process#GO:0009987;lipid metabolic process#GO:0006629;lipid catabolic process#GO:0016042;catabolic process#GO:0009056 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 lipase#PC00143;metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HUMAN|HGNC=34005|UniProtKB=A8CG34 A8CG34 POM121C PTHR23193:SF5 NUCLEAR PORE COMPLEX PROTEIN NUP NUCLEAR ENVELOPE PORE MEMBRANE PROTEIN POM 121C-RELATED nucleocytoplasmic carrier activity#GO:0140142;molecular carrier activity#GO:0140104;structural molecule activity#GO:0005198;structural constituent of nuclear pore#GO:0017056 intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;nitrogen compound transport#GO:0071705;protein localization to nucleus#GO:0034504;import into nucleus#GO:0051170;macromolecule localization#GO:0033036;nucleocytoplasmic transport#GO:0006913;protein transport#GO:0015031;protein import into nucleus#GO:0006606;nuclear export#GO:0051168;nuclear transport#GO:0051169;nucleic acid transport#GO:0050657;cellular localization#GO:0051641;localization#GO:0051179;establishment of RNA localization#GO:0051236;RNA transport#GO:0050658;RNA localization#GO:0006403;protein localization to organelle#GO:0033365;nucleobase-containing compound transport#GO:0015931 intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;organelle#GO:0043226;nucleus#GO:0005634;organelle envelope#GO:0031967;nuclear pore#GO:0005643;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229 transporter#PC00227 HUMAN|HGNC=25484|UniProtKB=Q2KJY2 Q2KJY2 KIF26B PTHR21608:SF8 KINESIN-LIKE PROTEIN CG14535 KINESIN-LIKE PROTEIN KIF26B tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;microtubule binding#GO:0008017;protein binding#GO:0005515 multicellular organismal process#GO:0032501;tissue development#GO:0009888;epithelium development#GO:0060429;regulation of locomotion#GO:0040012;tube development#GO:0035295;biological regulation#GO:0065007;kidney development#GO:0001822;renal system development#GO:0072001;animal organ development#GO:0048513;developmental growth#GO:0048589;multicellular organism development#GO:0007275;morphogenesis of an epithelium#GO:0002009;anatomical structure formation involved in morphogenesis#GO:0048646;regulation of neuron migration#GO:2001222;growth#GO:0040007;developmental process#GO:0032502;regulation of cell migration#GO:0030334;regulation of cellular process#GO:0050794;animal organ morphogenesis#GO:0009887;tube morphogenesis#GO:0035239;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;tissue morphogenesis#GO:0048729;regulation of cell motility#GO:2000145;developmental growth involved in morphogenesis#GO:0060560;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108 HUMAN|HGNC=3092|UniProtKB=Q9Y463 Q9Y463 DYRK1B PTHR24058:SF12 DUAL SPECIFICITY PROTEIN KINASE DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 1B protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transcription regulator activity#GO:0140110;protein serine/threonine kinase activity#GO:0004674;transcription coactivator activity#GO:0003713;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transcription coregulator activity#GO:0003712;catalytic activity#GO:0003824;transferase activity#GO:0016740 regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;regulation of DNA-templated transcription#GO:0006355;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 protein modifying enzyme#PC00260 HUMAN|HGNC=21200|UniProtKB=Q8N9F8 Q8N9F8 ZNF454 PTHR24377:SF1053 IP01015P-RELATED ZINC FINGER PROTEIN 454 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=6356|UniProtKB=Q96PQ7 Q96PQ7 KLHL5 PTHR24412:SF135 KELCH PROTEIN KELCH-LIKE PROTEIN 5 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;enzyme-substrate adaptor activity#GO:0140767;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 Cul3-RING ubiquitin ligase complex#GO:0031463;ubiquitin ligase complex#GO:0000151;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;transferase complex#GO:1990234;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cullin-RING ubiquitin ligase complex#GO:0031461;cytoplasm#GO:0005737 scaffold/adaptor protein#PC00226 HUMAN|HGNC=3673|UniProtKB=O60258 O60258 FGF17 PTHR11486:SF71 FIBROBLAST GROWTH FACTOR FIBROBLAST GROWTH FACTOR 17 signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515;molecular function activator activity#GO:0140677;growth factor activity#GO:0008083;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;growth factor receptor binding#GO:0070851;fibroblast growth factor receptor binding#GO:0005104;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772 positive regulation of cell population proliferation#GO:0008284;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;cell differentiation#GO:0030154;signaling#GO:0023052;animal gross anatomical part developmental process#GO:0160108;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;cellular response to growth factor stimulus#GO:0071363;cellular process#GO:0009987;cellular response to fibroblast growth factor stimulus#GO:0044344;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;nervous system development#GO:0007399;cell surface receptor signaling pathway#GO:0007166;regulation of MAPK cascade#GO:0043408;multicellular organism development#GO:0007275;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;response to growth factor#GO:0070848;regulation of cell communication#GO:0010646;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;regulation of cell motility#GO:2000145;regulation of cell population proliferation#GO:0042127;cell communication#GO:0007154;system development#GO:0048731;positive regulation of cellular process#GO:0048522;fibroblast growth factor receptor signaling pathway#GO:0008543;multicellular organismal process#GO:0032501;positive regulation of response to stimulus#GO:0048584;regulation of locomotion#GO:0040012;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;response to fibroblast growth factor#GO:0071774;regulation of response to stimulus#GO:0048583;developmental process#GO:0032502;positive regulation of intracellular signal transduction#GO:1902533;regulation of cell migration#GO:0030334;cellular developmental process#GO:0048869;positive regulation of MAPK cascade#GO:0043410;neurogenesis#GO:0022008 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 intercellular signal molecule#PC00207;growth factor#PC00112 FGF signaling pathway#P00021>FGF#P00623 HUMAN|HGNC=13192|UniProtKB=Q99543 Q99543 DNAJC2 PTHR43999:SF1 DNAJ HOMOLOG SUBFAMILY C MEMBER 2 DNAJ HOMOLOG SUBFAMILY C MEMBER 2 binding#GO:0005488;ribosome binding#GO:0043022;protein-containing complex binding#GO:0044877;protein binding#GO:0005515;ribonucleoprotein complex binding#GO:0043021;heat shock protein binding#GO:0031072;protein-folding chaperone binding#GO:0051087;Hsp70 protein binding#GO:0030544 primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;protein maturation#GO:0051604;protein folding#GO:0006457;biosynthetic process#GO:0009058;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 chaperone#PC00072 HUMAN|HGNC=26643|UniProtKB=Q6IQ49 Q6IQ49 SDE2 PTHR12786:SF1 SPLICING FACTOR SF3A-RELATED SPLICING REGULATOR SDE2 RNA binding#GO:0003723;binding#GO:0005488;snoRNA binding#GO:0030515;nucleic acid binding#GO:0003676 RNA biosynthetic process#GO:0032774;mRNA cis splicing, via spliceosome#GO:0045292;mRNA metabolic process#GO:0016071;mRNA splicing, via spliceosome#GO:0000398;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;spliceosomal complex#GO:0005681;post-mRNA release spliceosomal complex#GO:0071014;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904 RNA splicing factor#PC00148 HUMAN|HGNC=3774|UniProtKB=Q06828 Q06828 FMOD PTHR45712:SF4 AGAP008170-PA FIBROMODULIN cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=6727|UniProtKB=Q16553 Q16553 LY6E PTHR16983:SF13 UPAR/LY6 DOMAIN-CONTAINING PROTEIN LYMPHOCYTE ANTIGEN 6E molecular function regulator activity#GO:0098772;signaling receptor regulator activity#GO:0030545;neurotransmitter receptor regulator activity#GO:0099602;molecular function inhibitor activity#GO:0140678;signaling receptor inhibitor activity#GO:0030547;protein binding#GO:0005515;acetylcholine receptor regulator activity#GO:0030548;acetylcholine receptor inhibitor activity#GO:0030550;signaling receptor binding#GO:0005102;binding#GO:0005488 response to chemical#GO:0042221;cellular response to nitrogen compound#GO:1901699;acetylcholine receptor signaling pathway#GO:0095500;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;synaptic signaling#GO:0099536;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987;cell communication#GO:0007154;response to nitrogen compound#GO:1901698;cellular response to chemical stimulus#GO:0070887;response to oxygen-containing compound#GO:1901700;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 protein-binding activity modulator#PC00095 HUMAN|HGNC=16274|UniProtKB=Q96J86 Q96J86 CYYR1 PTHR38490:SF1 CYSTEINE AND TYROSINE-RICH PROTEIN 1 CYSTEINE AND TYROSINE-RICH PROTEIN 1 HUMAN|HGNC=19717|UniProtKB=Q8NEA9 Q8NEA9 GMCL2 PTHR23231:SF18 GERM CELL-LESS PROTEIN GERM CELL-LESS PROTEIN-LIKE 2 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=11401|UniProtKB=Q96PF2 Q96PF2 TSSK2 PTHR24343:SF120 SERINE/THREONINE KINASE TESTIS-SPECIFIC SERINE_THREONINE-PROTEIN KINASE 2 catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674 cell differentiation#GO:0030154;gamete generation#GO:0007276;cellular process involved in reproduction in multicellular organism#GO:0022412;cell development#GO:0048468;reproductive process#GO:0022414;developmental process involved in reproduction#GO:0003006;germ cell development#GO:0007281;anatomical structure development#GO:0048856;multicellular organismal reproductive process#GO:0048609;spermatid differentiation#GO:0048515;sexual reproduction#GO:0019953;spermatid development#GO:0007286;male gamete generation#GO:0048232;cellular process#GO:0009987;cellular developmental process#GO:0048869;developmental process#GO:0032502;spermatogenesis#GO:0007283 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=30959|UniProtKB=Q8IWR0 Q8IWR0 ZC3H7A PTHR14928:SF13 MICRO-RNA BINDING ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 7 ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 7A binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;nucleic acid biosynthetic process#GO:0141187;miRNA processing#GO:0035196;RNA metabolic process#GO:0016070;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;RNA processing#GO:0006396;gene expression#GO:0010467;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;macromolecule biosynthetic process#GO:0009059;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of biosynthetic process#GO:0009890;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;regulatory ncRNA-mediated gene silencing#GO:0031047;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulatory ncRNA processing#GO:0070918 RNA metabolism protein#PC00031 HUMAN|HGNC=29155|UniProtKB=Q9Y2G0 Q9Y2G0 EFR3B PTHR12444:SF4 PROTEIN EFR3 HOMOLOG CMP44E PROTEIN EFR3 HOMOLOG B protein-membrane adaptor activity#GO:0043495;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 protein localization to membrane#GO:0072657;macromolecule localization#GO:0033036;protein localization to plasma membrane#GO:0072659;cellular process#GO:0009987;localization#GO:0051179;cellular localization#GO:0051641;intracellular protein localization#GO:0008104;protein localization to cell periphery#GO:1990778;localization within membrane#GO:0051668 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HUMAN|HGNC=21215|UniProtKB=Q9H6K1 Q9H6K1 ILRUN PTHR20930:SF10 OVARIAN CARCINOMA ANTIGEN CA125-RELATED PROTEIN ILRUN biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;macroautophagy#GO:0016236;negative regulation of macromolecule metabolic process#GO:0010605;macromolecule localization#GO:0033036;regulation of cytokine production#GO:0001817;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;intracellular protein localization#GO:0008104;regulation of gene expression#GO:0010468;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;regulation of biosynthetic process#GO:0009889;vacuolar transport#GO:0007034;transport#GO:0006810;intracellular transport#GO:0046907;negative regulation of cellular process#GO:0048523;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;protein localization to organelle#GO:0033365;negative regulation of multicellular organismal process#GO:0051241;localization#GO:0051179;protein localization to vacuole#GO:0072665;regulation of multicellular organismal process#GO:0051239;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;autophagy#GO:0006914;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;protein targeting to vacuole#GO:0006623;regulation of localization#GO:0032879;intracellular protein transport#GO:0006886;metabolic process#GO:0008152;negative regulation of metabolic process#GO:0009892;establishment of protein localization to vacuole#GO:0072666;protein targeting#GO:0006605;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of protein localization#GO:0032880;protein transport#GO:0015031;process utilizing autophagic mechanism#GO:0061919;cellular localization#GO:0051641 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;autophagosome#GO:0005776;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;vacuole#GO:0005773;cytosol#GO:0005829;nucleus#GO:0005634 HUMAN|HGNC=31412|UniProtKB=Q1ZZU3 Q1ZZU3 SWI5 PTHR28529:SF2 DNA REPAIR PROTEIN SWI5 HOMOLOG DNA REPAIR PROTEIN SWI5 HOMOLOG response to stimulus#GO:0050896;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;double-strand break repair via homologous recombination#GO:0000724;cellular response to stimulus#GO:0051716;recombinational repair#GO:0000725;cellular response to stress#GO:0033554;nucleobase-containing compound metabolic process#GO:0006139;response to stress#GO:0006950;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;double-strand break repair#GO:0006302;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA recombination#GO:0006310;DNA damage response#GO:0006974 organelle lumen#GO:0043233;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;chromatin#GO:0000785;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513 DNA metabolism protein#PC00009 HUMAN|HGNC=10332|UniProtKB=P39023 P39023 RPL3 PTHR11363:SF4 60S RIBOSOMAL PROTEIN L3-RELATED LARGE RIBOSOMAL SUBUNIT PROTEIN UL3 RNA binding#GO:0003723;structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;binding#GO:0005488 primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;biosynthetic process#GO:0009058;metabolic process#GO:0008152;translation#GO:0006412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;ribosome#GO:0005840;cytosol#GO:0005829;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625 ribosomal protein#PC00202;translational protein#PC00263 HUMAN|HGNC=26695|UniProtKB=Q8N9W4 Q8N9W4 GOLGA6L2 PTHR23143:SF28 TRICHOHYALIN-RELATED GOLGIN SUBFAMILY A MEMBER 6-LIKE PROTEIN 2 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=21145|UniProtKB=Q96D15 Q96D15 RCN3 PTHR10827:SF47 RETICULOCALBIN RETICULOCALBIN-3 ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;calcium ion binding#GO:0005509;metal ion binding#GO:0046872;cation binding#GO:0043169 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 calmodulin-related#PC00061;calcium-binding protein#PC00060 HUMAN|HGNC=1865|UniProtKB=Q6UWW8 Q6UWW8 CES3 PTHR11559:SF416 CARBOXYLESTERASE CARBOXYLESTERASE 3 hydrolase activity, acting on ester bonds#GO:0016788;carboxylic ester hydrolase activity#GO:0052689;catalytic activity#GO:0003824;hydrolase activity#GO:0016787 esterase#PC00097 HUMAN|HGNC=19612|UniProtKB=Q8NH18 Q8NH18 OR5J2 PTHR26452:SF418 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5J2 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 sensory perception#GO:0007600;nervous system process#GO:0050877;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=24667|UniProtKB=Q8TD08 Q8TD08 MAPK15 PTHR24055:SF79 MITOGEN-ACTIVATED PROTEIN KINASE MITOGEN-ACTIVATED PROTEIN KINASE 15 transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 non-receptor serine/threonine protein kinase#PC00167 PDGF signaling pathway#P00047>ERK#P01143;Alzheimer disease-amyloid secretase pathway#P00003>MAPK#P00099;Interleukin signaling pathway#P00036>ERK#P00965;Interferon-gamma signaling pathway#P00035>Serine kinase#P00955;Parkinson disease#P00049>ERK#P01211;EGF receptor signaling pathway#P00018>ERK1-2#P00543 HUMAN|HGNC=15734|UniProtKB=Q96J84 Q96J84 KIRREL1 PTHR11640:SF14 NEPHRIN KIN OF IRRE-LIKE PROTEIN 1 protein binding#GO:0005515;binding#GO:0005488;cell adhesion molecule binding#GO:0050839 cell-cell adhesion#GO:0098609;cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;cell-cell junction#GO:0005911;membrane#GO:0016020;plasma membrane#GO:0005886;anchoring junction#GO:0070161;cell junction#GO:0030054;cellular anatomical structure#GO:0110165 immunoglobulin superfamily cell adhesion molecule#PC00125;cell adhesion molecule#PC00069 HUMAN|HGNC=11544|UniProtKB=Q15544 Q15544 TAF11 PTHR13218:SF16 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11-RELATED TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11 transcription initiation at RNA polymerase II promoter#GO:0006367;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;cellular component assembly#GO:0022607;nucleobase-containing compound metabolic process#GO:0006139;protein-DNA complex assembly#GO:0065004;biosynthetic process#GO:0009058;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;transcription by RNA polymerase II#GO:0006366;protein-DNA complex organization#GO:0071824;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-containing complex organization#GO:0043933;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;protein-containing complex assembly#GO:0065003;DNA-templated transcription initiation#GO:0006352;RNA polymerase II preinitiation complex assembly#GO:0051123;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070 protein-containing complex#GO:0032991;transcription factor TFIID complex#GO:0005669;membrane-enclosed lumen#GO:0031974;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;transcription regulator complex#GO:0005667;transferase complex#GO:1990234;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;RNA polymerase II, holoenzyme#GO:0016591;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;membrane-bounded organelle#GO:0043227;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494 RNA metabolism protein#PC00031;general transcription factor#PC00259 Transcription regulation by bZIP transcription factor#P00055>TBP-associated factors#P01385;General transcription regulation#P00023>TBP-associated factors#P00658 HUMAN|HGNC=2259|UniProtKB=Q16206 Q16206 ENOX2 PTHR16001:SF7 ANGEL WING family ECTO-NOX DISULFIDE-THIOL EXCHANGER 2 oxidoreductase#PC00176 HUMAN|HGNC=195|UniProtKB=P78536 P78536 ADAM17 PTHR45702:SF6 ADAM10/ADAM17 METALLOPEPTIDASE FAMILY MEMBER DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17 hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 biological regulation#GO:0065007;membrane protein ectodomain proteolysis#GO:0006509;signal transduction#GO:0007165;membrane protein proteolysis#GO:0033619;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;Notch signaling pathway#GO:0007219;cell surface receptor signaling pathway#GO:0007166;metabolic process#GO:0008152;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;cell communication#GO:0007154;protein metabolic process#GO:0019538;proteolysis#GO:0006508 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 protease#PC00190;protein modifying enzyme#PC00260 Alzheimer disease-presenilin pathway#P00004>TACE#P00147;Notch signaling pathway#P00045>TACE#P01105;Alzheimer disease-amyloid secretase pathway#P00003>TACE#P00092 HUMAN|HGNC=11963|UniProtKB=Q8NFJ8 Q8NFJ8 BHLHE22 PTHR19290:SF52 BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED CLASS E BASIC HELIX-LOOP-HELIX PROTEIN 22 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 cell differentiation#GO:0030154;cell projection organization#GO:0030030;regulation of transcription by RNA polymerase II#GO:0006357;cell development#GO:0048468;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;positive regulation of macromolecule metabolic process#GO:0010604;nervous system development#GO:0007399;neuron projection development#GO:0031175;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;animal organ development#GO:0048513;positive regulation of transcription by RNA polymerase II#GO:0045944;neuron differentiation#GO:0030182;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;positive regulation of DNA-templated transcription#GO:0045893;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;plasma membrane bounded cell projection organization#GO:0120036;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;axon development#GO:0061564;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;sensory organ development#GO:0007423;developmental process#GO:0032502 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=18818|UniProtKB=Q8NF99 Q8NF99 ZNF397 PTHR23226:SF85 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER PROTEIN 397 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=29670|UniProtKB=Q3T906 Q3T906 GNPTAB PTHR24045:SF1 FAMILY NOT NAMED N-ACETYLGLUCOSAMINE-1-PHOSPHOTRANSFERASE SUBUNITS ALPHA_BETA phosphotransferase activity, for other substituted phosphate groups#GO:0016780;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824 protein metabolic process#GO:0019538;localization#GO:0051179;vacuole organization#GO:0007033;protein localization to vacuole#GO:0072665;protein localization to organelle#GO:0033365;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;establishment of protein localization to organelle#GO:0072594;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;lytic vacuole organization#GO:0080171;transport#GO:0006810;vacuolar transport#GO:0007034;biosynthetic process#GO:0009058;glycoprotein biosynthetic process#GO:0009101;macromolecule localization#GO:0033036;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;cellular localization#GO:0051641;protein transport#GO:0015031;lysosomal transport#GO:0007041;protein targeting#GO:0006605;establishment of protein localization to vacuole#GO:0072666;cellular component organization#GO:0016043;protein localization to lysosome#GO:0061462;carbohydrate derivative biosynthetic process#GO:1901137;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;intracellular protein transport#GO:0006886;glycoprotein metabolic process#GO:0009100;protein targeting to vacuole#GO:0006623;organelle organization#GO:0006996;lysosome organization#GO:0007040;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 HUMAN|HGNC=10513|UniProtKB=P0DJI8 P0DJI8 SAA1 PTHR23424:SF36 SERUM AMYLOID A SERUM AMYLOID A-1 PROTEIN transfer/carrier protein#PC00219;apolipoprotein#PC00052 HUMAN|HGNC=41983|UniProtKB=P0DM63 P0DM63 NPIPA8 PTHR15438:SF5 NUCLEAR PORE COMPLEX INTERACTING PROTEIN NUCLEAR PORE COMPLEX INTERACTING PROTEIN FAMILY MEMBER B3-RELATED HUMAN|HGNC=3287|UniProtKB=P06730 P06730 EIF4E PTHR11960:SF14 EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED EUKARYOTIC TRANSLATION INITIATION FACTOR 4E translation initiation factor activity#GO:0003743;RNA binding#GO:0003723;translation factor activity#GO:0180051;binding#GO:0005488;nucleic acid binding#GO:0003676 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;translation#GO:0006412;translational initiation#GO:0006413;metabolic process#GO:0008152;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular protein-containing complex#GO:0140535;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 translational protein#PC00263;translation initiation factor#PC00224;translation factor#PC00223 CCKR signaling map#P06959>EIF4E#P07094;p38 MAPK pathway#P05918>eIF4E#P06024 HUMAN|HGNC=14085|UniProtKB=Q9NQC3 Q9NQC3 RTN4 PTHR45799:SF1 RETICULON-LIKE PROTEIN RETICULON-4 cellular process#GO:0009987;endoplasmic reticulum organization#GO:0007029;organelle organization#GO:0006996;cellular component organization#GO:0016043;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;endoplasmic reticulum tubular network organization#GO:0071786;endoplasmic reticulum membrane organization#GO:0090158;cellular component organization or biogenesis#GO:0071840 membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=19422|UniProtKB=O75528 O75528 TADA3 PTHR13556:SF2 TRANSCRIPTIONAL ADAPTER 3-RELATED TRANSCRIPTIONAL ADAPTER 3 transcription coactivator activity#GO:0003713;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 chromosome#GO:0005694;organelle#GO:0043226;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;protein acetyltransferase complex#GO:0031248;SAGA-type complex#GO:0070461;acetyltransferase complex#GO:1902493;intracellular anatomical structure#GO:0005622;SAGA complex#GO:0000124;chromatin#GO:0000785;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;peptidase complex#GO:1905368;transferase complex#GO:1990234;membraneless organelle#GO:0043228;histone acetyltransferase complex#GO:0000123;intracellular protein-containing complex#GO:0140535 histone modifying enzyme#PC00261 HUMAN|HGNC=19685|UniProtKB=P49903 P49903 SEPHS1 PTHR10256:SF2 SELENIDE, WATER DIKINASE ZINCORE COMPONENT SEPHS1 catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 amino acid metabolic process#GO:0006520;biosynthetic process#GO:0009058;proteinogenic amino acid metabolic process#GO:0170039;small molecule metabolic process#GO:0044281;cellular process#GO:0009987;carboxylic acid biosynthetic process#GO:0046394;modified amino acid metabolic process#GO:0006575;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;proteinogenic amino acid biosynthetic process#GO:0170038;small molecule biosynthetic process#GO:0044283;amino acid biosynthetic process#GO:0008652;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 metabolite interconversion enzyme#PC00262;transferase#PC00220 HUMAN|HGNC=26504|UniProtKB=Q96MI9 Q96MI9 AGBL1 PTHR12756:SF5 CYTOSOLIC CARBOXYPEPTIDASE CYTOSOLIC CARBOXYPEPTIDASE 4 metallopeptidase activity#GO:0008237;binding#GO:0005488;carboxypeptidase activity#GO:0004180;protein binding#GO:0005515;metallocarboxypeptidase activity#GO:0004181;hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;cytoskeletal protein binding#GO:0008092;metalloexopeptidase activity#GO:0008235;tubulin binding#GO:0015631;catalytic activity#GO:0003824;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096 microtubule cytoskeleton#GO:0015630;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 metalloprotease#PC00153 HUMAN|HGNC=2709|UniProtKB=P40126 P40126 DCT PTHR11474:SF4 TYROSINASE FAMILY MEMBER L-DOPACHROME TAUTOMERASE catalytic activity#GO:0003824;monooxygenase activity#GO:0004497;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;oxidoreductase activity#GO:0016491;intramolecular oxidoreductase activity#GO:0016860;isomerase activity#GO:0016853 melanin biosynthetic process#GO:0042438;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;forebrain development#GO:0030900;central nervous system development#GO:0007417;cell differentiation#GO:0030154;positive regulation of nervous system development#GO:0051962;positive regulation of cell population proliferation#GO:0008284;positive regulation of multicellular organismal process#GO:0051240;regulation of multicellular organismal development#GO:2000026;phenol-containing compound metabolic process#GO:0018958;regulation of biological process#GO:0050789;animal organ development#GO:0048513;multicellular organism development#GO:0007275;secondary metabolite biosynthetic process#GO:0044550;metabolic process#GO:0008152;positive regulation of cell differentiation#GO:0045597;head development#GO:0060322;regulation of multicellular organismal process#GO:0051239;positive regulation of cell development#GO:0010720;nervous system development#GO:0007399;phenol-containing compound biosynthetic process#GO:0046189;developmental pigmentation#GO:0048066;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;anatomical structure development#GO:0048856;regulation of nervous system development#GO:0051960;regulation of cell population proliferation#GO:0042127;system development#GO:0048731;cell population proliferation#GO:0008283;pigmentation#GO:0043473;regulation of cellular process#GO:0050794;positive regulation of neurogenesis#GO:0050769;regulation of developmental process#GO:0050793;regulation of neurogenesis#GO:0050767;cell division#GO:0051301;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;secondary metabolic process#GO:0019748;regulation of cell differentiation#GO:0045595;positive regulation of developmental process#GO:0051094;developmental process#GO:0032502;pigment biosynthetic process#GO:0046148;multicellular organismal process#GO:0032501;brain development#GO:0007420;biological regulation#GO:0065007;biosynthetic process#GO:0009058;pigment metabolic process#GO:0042440;regulation of cell development#GO:0060284;positive regulation of cellular process#GO:0048522 intracellular membrane-bounded organelle#GO:0043231;melanosome#GO:0042470;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular vesicle#GO:0097708;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 oxygenase#PC00177 HUMAN|HGNC=24078|UniProtKB=O43827 O43827 ANGPTL7 PTHR19143:SF40 FIBRINOGEN/TENASCIN/ANGIOPOEITIN ANGIOPOIETIN-RELATED PROTEIN 7 regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;sensory system development#GO:0048880;animal organ development#GO:0048513;multicellular organism development#GO:0007275;developmental process#GO:0032502;regulation of vasculature development#GO:1901342;sensory organ development#GO:0007423;visual system development#GO:0150063;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of multicellular organismal development#GO:2000026;regulation of biological process#GO:0050789;negative regulation of multicellular organismal process#GO:0051241;negative regulation of biological process#GO:0048519;eye development#GO:0001654;system development#GO:0048731;anatomical structure development#GO:0048856;animal gross anatomical part developmental process#GO:0160108;camera-type eye development#GO:0043010 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 intercellular signal molecule#PC00207 HUMAN|HGNC=2158|UniProtKB=P09543 P09543 CNP PTHR10156:SF0 2',3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE 2',3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;cyclic-nucleotide phosphodiesterase activity#GO:0004112;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;phosphoric diester hydrolase activity#GO:0008081 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 phosphodiesterase#PC00185 HUMAN|HGNC=25694|UniProtKB=Q8TC07 Q8TC07 TBC1D15 PTHR22957:SF300 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN TBC1 DOMAIN FAMILY MEMBER 15 enzyme activator activity#GO:0008047;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234 G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HUMAN|HGNC=19112|UniProtKB=P59541 P59541 TAS2R30 PTHR11394:SF48 TASTE RECEPTOR TYPE 2 TASTE RECEPTOR TYPE 2 MEMBER 30 transmembrane signaling receptor activity#GO:0004888;bitter taste receptor activity#GO:0033038;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;taste receptor activity#GO:0008527 system process#GO:0003008;detection of chemical stimulus involved in sensory perception of bitter taste#GO:0001580;sensory perception#GO:0007600;nervous system process#GO:0050877;detection of chemical stimulus involved in sensory perception of taste#GO:0050912;sensory perception of taste#GO:0050909;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;response to chemical#GO:0042221;response to stimulus#GO:0050896;multicellular organismal process#GO:0032501;detection of chemical stimulus#GO:0009593;sensory perception of bitter taste#GO:0050913;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606 membrane#GO:0016020;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=6848|UniProtKB=Q13233 Q13233 MAP3K1 PTHR24361:SF414 MITOGEN-ACTIVATED KINASE KINASE KINASE MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 1 catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 intracellular signal transduction#GO:0035556;MAPK cascade#GO:0000165;cell communication#GO:0007154;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Gonadotropin-releasing hormone receptor pathway#P06664>MAP3Ks#P06834;Apoptosis signaling pathway#P00006>MEKK1#P00291;T cell activation#P00053>MEKK#P01297;FGF signaling pathway#P00021>MEKK1-5#P00634;Toll receptor signaling pathway#P00054>MEKK1#P01357;Integrin signalling pathway#P00034>ERK#P00907;Angiogenesis#P00005>MEKK1#P00208;Ras Pathway#P04393>MEKK1/4#P04543;EGF receptor signaling pathway#P00018>MEKK1-5#P00553 HUMAN|HGNC=4904|UniProtKB=C9JL84 C9JL84 HHLA1 PTHR15299:SF3 HERV-H LTR-ASSOCIATING PROTEIN 1 HERV-H LTR-ASSOCIATING PROTEIN 1 HUMAN|HGNC=16287|UniProtKB=Q9UMS0 Q9UMS0 NFU1 PTHR11178:SF1 IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED NFU1 IRON-SULFUR CLUSTER SCAFFOLD HOMOLOG, MITOCHONDRIAL iron-sulfur cluster binding#GO:0051536;small molecule binding#GO:0036094;binding#GO:0005488 gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739 HUMAN|HGNC=27801|UniProtKB=Q5FWF6 Q5FWF6 ZNF789 PTHR24377:SF196 IP01015P-RELATED ZINC FINGER PROTEIN 789 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=26943|UniProtKB=Q7LFL8 Q7LFL8 CXXC5 PTHR13419:SF2 ZINC FINGER-CONTAINING CXXC-TYPE ZINC FINGER PROTEIN 5 heterocyclic compound binding#GO:1901363;nucleotide binding#GO:0000166;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;nucleic acid binding#GO:0003676;binding#GO:0005488;small molecule binding#GO:0036094;nucleoside phosphate binding#GO:1901265 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=16344|UniProtKB=A0A0G2JNF4 A0A0G2JNF4 KIR2DP1 PTHR11738:SF168 MHC CLASS I NK CELL RECEPTOR IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN-RELATED transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;immune receptor activity#GO:0140375 cell communication#GO:0007154;regulation of immune response#GO:0050776;cell surface receptor signaling pathway#GO:0007166;regulation of response to stimulus#GO:0048583;response to stimulus#GO:0050896;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;signal transduction#GO:0007165;regulation of biological process#GO:0050789;immune response-regulating signaling pathway#GO:0002764;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=18483|UniProtKB=Q8WWY8 Q8WWY8 LIPH PTHR11610:SF12 LIPASE LIPASE MEMBER H hydrolase activity#GO:0016787;phospholipase activity#GO:0120569;hydrolase activity, acting on ester bonds#GO:0016788;glycerophospholipase activity#GO:0004620;catalytic activity#GO:0003824;lipase activity#GO:0016298 catabolic process#GO:0009056;primary metabolic process#GO:0044238;metabolic process#GO:0008152;cellular process#GO:0009987;lipid metabolic process#GO:0006629;lipid catabolic process#GO:0016042 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 hydrolase#PC00121;metabolite interconversion enzyme#PC00262;lipase#PC00143 2-arachidonoylglycerol biosynthesis#P05726>PLA1#P05735 HUMAN|HGNC=16940|UniProtKB=Q96PD7 Q96PD7 DGAT2 PTHR12317:SF14 DIACYLGLYCEROL O-ACYLTRANSFERASE DIACYLGLYCEROL O-ACYLTRANSFERASE 2 acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746 biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;glycerolipid metabolic process#GO:0046486;triglyceride biosynthetic process#GO:0019432;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;primary metabolic process#GO:0044238;neutral lipid metabolic process#GO:0006638;triglyceride metabolic process#GO:0006641;lipid metabolic process#GO:0006629;acylglycerol metabolic process#GO:0006639;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;membrane#GO:0016020;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789 acyltransferase#PC00042;transferase#PC00220 HUMAN|HGNC=3758|UniProtKB=Q14254 Q14254 FLOT2 PTHR13806:SF46 FLOTILLIN-RELATED FLOTILLIN-2 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HUMAN|HGNC=8689|UniProtKB=Q9Y5E5 Q9Y5E5 PCDHB4 PTHR24028:SF55 CADHERIN-87A PROTOCADHERIN BETA-4 cellular process#GO:0009987;cell adhesion#GO:0007155 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 cadherin#PC00057;cell adhesion molecule#PC00069 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HUMAN|HGNC=9869|UniProtKB=Q9UL19 Q9UL19 PLAAT4 PTHR13943:SF36 HRAS-LIKE SUPPRESSOR - RELATED PHOSPHOLIPASE A AND ACYLTRANSFERASE 4 catalytic activity#GO:0003824;glycerophospholipase activity#GO:0004620;transferase activity#GO:0016740;hydrolase activity, acting on ester bonds#GO:0016788;phospholipase activity#GO:0120569;A2-type glycerophospholipase activity#GO:0004623;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acyltransferase activity#GO:0016746;lipase activity#GO:0016298;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity#GO:0016787 metabolic process#GO:0008152;lipid metabolic process#GO:0006629;glycerophospholipid metabolic process#GO:0006650;glycerolipid metabolic process#GO:0046486;phospholipid metabolic process#GO:0006644;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 acyltransferase#PC00042;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=6339|UniProtKB=P43630 P43630 KIR3DL2 PTHR11738:SF166 MHC CLASS I NK CELL RECEPTOR KILLER CELL IMMUNOGLOBULIN-LIKE RECEPTOR 3DL1-RELATED transmembrane signaling receptor activity#GO:0004888;immune receptor activity#GO:0140375;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 immune response-regulating cell surface receptor signaling pathway#GO:0002768;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;immune response-regulating signaling pathway#GO:0002764;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;regulation of immune response#GO:0050776;cell surface receptor signaling pathway#GO:0007166;regulation of response to stimulus#GO:0048583 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=30579|UniProtKB=Q8WYL5 Q8WYL5 SSH1 PTHR45864:SF5 SLINGSHOT PROTEIN PHOSPHATASE HOMOLOG PROTEIN PHOSPHATASE SLINGSHOT HOMOLOG 1 protein binding#GO:0005515;hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721;binding#GO:0005488;actin binding#GO:0003779;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;cytoskeletal protein binding#GO:0008092;phosphatase activity#GO:0016791 negative regulation of cellular process#GO:0048523;regulation of actin filament-based process#GO:0032970;regulation of actin filament organization#GO:0110053;regulation of actin filament polymerization#GO:0030833;regulation of actin polymerization or depolymerization#GO:0008064;biological regulation#GO:0065007;actin filament-based process#GO:0030029;negative regulation of protein polymerization#GO:0032272;negative regulation of cytoskeleton organization#GO:0051494;negative regulation of protein-containing complex assembly#GO:0031333;negative regulation of cellular component organization#GO:0051129;negative regulation of organelle organization#GO:0010639;regulation of supramolecular fiber organization#GO:1902903;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;regulation of protein polymerization#GO:0032271;regulation of cytoskeleton organization#GO:0051493;negative regulation of supramolecular fiber organization#GO:1902904;regulation of anatomical structure size#GO:0090066;cellular component organization or biogenesis#GO:0071840;organelle organization#GO:0006996;cellular process#GO:0009987;regulation of actin cytoskeleton organization#GO:0032956;cytoskeleton organization#GO:0007010;regulation of actin filament length#GO:0030832;regulation of biological quality#GO:0065008;regulation of protein-containing complex assembly#GO:0043254;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of cellular component size#GO:0032535;regulation of cellular component organization#GO:0051128;regulation of cellular component biogenesis#GO:0044087;negative regulation of actin filament polymerization#GO:0030837 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protein phosphatase#PC00195 Cytoskeletal regulation by Rho GTPase#P00016>Slingshot#P00509 HUMAN|HGNC=7531|UniProtKB=Q14764 Q14764 MVP PTHR14165:SF3 MAJOR VAULT PROTEIN MAJOR VAULT PROTEIN signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154 nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 scaffold/adaptor protein#PC00226 HUMAN|HGNC=19115|UniProtKB=P0DTE0 P0DTE0 TAS2R36 PTHR11394:SF139 TASTE RECEPTOR TYPE 2 TASTE RECEPTOR TYPE 2 MEMBER 19-RELATED transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;bitter taste receptor activity#GO:0033038;taste receptor activity#GO:0008527;signaling receptor activity#GO:0038023 detection of chemical stimulus involved in sensory perception of bitter taste#GO:0001580;system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of taste#GO:0050909;detection of chemical stimulus involved in sensory perception of taste#GO:0050912;nervous system process#GO:0050877;sensory perception#GO:0007600;multicellular organismal process#GO:0032501;response to chemical#GO:0042221;response to stimulus#GO:0050896;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;detection of chemical stimulus#GO:0009593;sensory perception of bitter taste#GO:0050913 membrane#GO:0016020;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=13727|UniProtKB=Q96S59 Q96S59 RANBP9 PTHR12864:SF56 RAN BINDING PROTEIN 9-RELATED RAN-BINDING PROTEIN 9 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 proteasomal protein catabolic process#GO:0010498;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;catabolic process#GO:0009056;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;modification-dependent protein catabolic process#GO:0019941;protein metabolic process#GO:0019538;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;ubiquitin ligase complex#GO:0000151;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;transferase complex#GO:1990234;catalytic complex#GO:1902494 scaffold/adaptor protein#PC00226 HUMAN|HGNC=20569|UniProtKB=Q9UK58 Q9UK58 CCNL1 PTHR10026:SF64 CYCLIN CYCLIN-L1 cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538;enzyme regulator activity#GO:0030234;protein kinase regulator activity#GO:0019887;cyclin-dependent protein kinase regulator activity#GO:0019914;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 kinase activator#PC00138;kinase modulator#PC00140 HUMAN|HGNC=14852|UniProtKB=Q8NGN0 Q8NGN0 OR4D5 PTHR48002:SF49 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 4D5 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=10447|UniProtKB=P10301 P10301 RRAS PTHR24070:SF245 RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY RAS-RELATED PROTEIN R-RAS catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signaling#GO:0023052;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;Ras protein signal transduction#GO:0007265;establishment or maintenance of cell polarity#GO:0007163;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 small GTPase#PC00208 Integrin signalling pathway#P00034>Ras#P00916;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Ras#P00869;TGF-beta signaling pathway#P00052>Ras-GTP#P01280;EGF receptor signaling pathway#P00018>Ras#P00552;TGF-beta signaling pathway#P00052>Ras-GDP#P01291 HUMAN|HGNC=35158|UniProtKB=A8MYZ5 A8MYZ5 IQCF6 PTHR21633:SF15 IQ MOTIF CONTAINING F IQ DOMAIN-CONTAINING PROTEIN F6 HUMAN|HGNC=16985|UniProtKB=Q9BTZ2 Q9BTZ2 DHRS4 PTHR43943:SF8 DEHYDROGENASE/REDUCTASE (SDR FAMILY) MEMBER 4 DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 4-RELATED oxidoreductase activity#GO:0016491;alcohol dehydrogenase (NADP+) activity#GO:0008106;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=7833|UniProtKB=P30414 P30414 NKTR PTHR11071:SF257 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE NK-TUMOR RECOGNITION PROTEIN nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 chaperone#PC00072 HUMAN|HGNC=24729|UniProtKB=Q96LP6 Q96LP6 C12orf42 PTHR40708:SF1 RIKEN CDNA 1700113H08 GENE RIKEN CDNA 1700113H08 GENE HUMAN|HGNC=9077|UniProtKB=P53350 P53350 PLK1 PTHR24345:SF93 SERINE/THREONINE-PROTEIN KINASE PLK SERINE_THREONINE-PROTEIN KINASE PLK1 protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824 microtubule cytoskeleton organization involved in mitosis#GO:1902850;cellular component organization#GO:0016043;organelle organization#GO:0006996;cell cycle#GO:0007049;cellular process#GO:0009987;cell cycle process#GO:0022402;mitotic spindle organization#GO:0007052;mitotic cell cycle#GO:0000278;cytoskeleton organization#GO:0007010;microtubule cytoskeleton organization#GO:0000226;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;mitotic cell cycle process#GO:1903047 spindle pole#GO:0000922;chromosome#GO:0005694;kinetochore#GO:0000776;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687;microtubule cytoskeleton#GO:0015630;condensed chromosome, centromeric region#GO:0000779;nucleus#GO:0005634;supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;spindle#GO:0005819;centrosome#GO:0005813;microtubule organizing center#GO:0005815;condensed chromosome#GO:0000793;chromosome, centromeric region#GO:0000775;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=4163|UniProtKB=P22102 P22102 GART PTHR10520:SF12 TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3-RELATED TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3 catalytic activity#GO:0003824;ligase activity#GO:0016874;ligase activity, forming carbon-nitrogen bonds#GO:0016879 nucleobase-containing small molecule metabolic process#GO:0055086;nucleobase metabolic process#GO:0009112;nucleoside phosphate biosynthetic process#GO:1901293;purine nucleobase metabolic process#GO:0006144;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;nucleotide biosynthetic process#GO:0009165;nucleotide metabolic process#GO:0009117;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 De novo purine biosynthesis#P02738>Phosphoribosylamine glycine ligase#P02908 HUMAN|HGNC=28782|UniProtKB=Q7Z6K5 Q7Z6K5 ARPIN PTHR31199:SF1 ARPIN ARPIN negative regulation of cytoskeleton organization#GO:0051494;regulation of cellular component organization#GO:0051128;negative regulation of supramolecular fiber organization#GO:1902904;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794;negative regulation of biological process#GO:0048519;negative regulation of cellular component organization#GO:0051129;negative regulation of organelle organization#GO:0010639;regulation of supramolecular fiber organization#GO:1902903;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;regulation of actin nucleation#GO:0051125;negative regulation of cellular process#GO:0048523;regulation of actin filament-based process#GO:0032970;biological regulation#GO:0065007;regulation of actin cytoskeleton organization#GO:0032956;regulation of actin filament organization#GO:0110053 HUMAN|HGNC=19845|UniProtKB=A4IF30 A4IF30 SLC35F4 PTHR19346:SF2 SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN SOLUTE CARRIER FAMILY 35 MEMBER F4 HUMAN|HGNC=18126|UniProtKB=Q9ULT6 Q9ULT6 ZNRF3 PTHR16200:SF3 RING ZINC FINGER E3 UBIQUITIN-PROTEIN LIGASE ZNRF3 signaling receptor binding#GO:0005102;binding#GO:0005488;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;protein binding#GO:0005515;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;transferase activity#GO:0016740;catalytic activity#GO:0003824;frizzled binding#GO:0005109;G protein-coupled receptor binding#GO:0001664;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 negative regulation of canonical Wnt signaling pathway#GO:0090090;negative regulation of signaling#GO:0023057;modification-dependent macromolecule catabolic process#GO:0043632;regulation of signaling#GO:0023051;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;negative regulation of cell communication#GO:0010648;primary metabolic process#GO:0044238;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;modification-dependent protein catabolic process#GO:0019941;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111;negative regulation of cellular process#GO:0048523;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;regulation of response to stimulus#GO:0048583;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;regulation of canonical Wnt signaling pathway#GO:0060828;cellular process#GO:0009987;negative regulation of response to stimulus#GO:0048585;negative regulation of Wnt signaling pathway#GO:0030178;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=40023|UniProtKB=A6NHS7 A6NHS7 MANSC4 PTHR46750:SF2 KUNITZ-TYPE PROTEASE INHIBITOR 1 MANSC DOMAIN-CONTAINING PROTEIN 4 molecular function inhibitor activity#GO:0140678;serine-type endopeptidase inhibitor activity#GO:0004867;enzyme regulator activity#GO:0030234;peptidase regulator activity#GO:0061134;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866;enzyme inhibitor activity#GO:0004857 external encapsulating structure organization#GO:0045229;anatomical structure development#GO:0048856;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;developmental process#GO:0032502;animal gross anatomical part developmental process#GO:0160108;extracellular structure organization#GO:0043062;epidermis development#GO:0008544;tissue development#GO:0009888;epithelium development#GO:0060429;cellular process#GO:0009987;cellular component organization#GO:0016043 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 protein-binding activity modulator#PC00095;protease inhibitor#PC00191 HUMAN|HGNC=26932|UniProtKB=Q9Y2S6 Q9Y2S6 TMA7 PTHR28632:SF11 TRANSLATION MACHINERY-ASSOCIATED PROTEIN 7 TRANSLATION MACHINERY-ASSOCIATED PROTEIN 7 HUMAN|HGNC=26425|UniProtKB=Q8N4P2 Q8N4P2 IFT70B PTHR20931:SF9 TETRATRICOPEPTIDE REPEAT PROTEIN 30 INTRAFLAGELLAR TRANSPORT PROTEIN 70B binding#GO:0005488;protein-containing complex binding#GO:0044877 localization#GO:0051179;cellular localization#GO:0051641;cilium organization#GO:0044782;microtubule-based transport#GO:0099111;cell projection organization#GO:0030030;microtubule-based movement#GO:0007018;intraciliary transport#GO:0042073;cellular component organization#GO:0016043;cellular component organization or biogenesis#GO:0071840;transport along microtubule#GO:0010970;establishment of localization#GO:0051234;microtubule-based process#GO:0007017;intracellular transport#GO:0046907;transport#GO:0006810;cytoskeleton-dependent intracellular transport#GO:0030705;plasma membrane bounded cell projection organization#GO:0120036;organelle organization#GO:0006996;establishment of localization in cell#GO:0051649;cellular process#GO:0009987 microtubule cytoskeleton#GO:0015630;supramolecular polymer#GO:0099081;ciliary plasm#GO:0097014;protein-containing complex#GO:0032991;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;intraciliary transport particle B#GO:0030992;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cytoplasmic microtubule#GO:0005881;cellular anatomical structure#GO:0110165;axonemal microtubule#GO:0005879;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;intraciliary transport particle#GO:0030990;intracellular organelle#GO:0043229;cilium#GO:0005929;axoneme#GO:0005930;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=23781|UniProtKB=Q9Y2S7 Q9Y2S7 POLDIP2 PTHR14289:SF16 F-BOX ONLY PROTEIN 3 POLYMERASE DELTA-INTERACTING PROTEIN 2 protein complex scaffold activity#GO:0140378;structural molecule activity#GO:0005198 cellular response to stress#GO:0033554;nucleic acid biosynthetic process#GO:0141187;DNA synthesis involved in DNA replication#GO:0090592;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;DNA replication#GO:0006260;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;nucleobase-containing compound biosynthetic process#GO:0034654;DNA damage response#GO:0006974;DNA damage tolerance#GO:0006301;macromolecule metabolic process#GO:0043170;response to stress#GO:0006950;DNA biosynthetic process#GO:0071897;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;translesion synthesis#GO:0019985 organelle lumen#GO:0043233;mitochondrion#GO:0005739;mitochondrial nucleoid#GO:0042645;organelle#GO:0043226;nucleoid#GO:0009295;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;membraneless organelle#GO:0043228 HUMAN|HGNC=103|UniProtKB=Q9H8M5 Q9H8M5 CNNM2 PTHR12064:SF22 METAL TRANSPORTER CNNM METAL TRANSPORTER CNNM2 magnesium ion transmembrane transporter activity#GO:0015095;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;monoatomic cation transmembrane transporter activity#GO:0008324 homeostatic process#GO:0042592;monoatomic ion homeostasis#GO:0050801;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;inorganic ion homeostasis#GO:0098771 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=5448|UniProtKB=P05000 P05000 IFNW1 PTHR11691:SF37 TYPE I INTERFERON INTERFERON OMEGA-1 molecular function activator activity#GO:0140677;protein-containing complex binding#GO:0044877;protein binding#GO:0005515;cytokine activity#GO:0005125;signaling receptor binding#GO:0005102;cytokine receptor binding#GO:0005126;binding#GO:0005488;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545 immune response#GO:0006955;multicellular organismal process#GO:0032501;adaptive immune response#GO:0002250;response to other organism#GO:0051707;biological regulation#GO:0065007;innate immune response#GO:0045087;defense response#GO:0006952;response to external stimulus#GO:0009605;leukocyte activation#GO:0045321;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;response to external biotic stimulus#GO:0043207;cytokine-mediated signaling pathway#GO:0019221;cell activation#GO:0001775;cell communication#GO:0007154;response to nitrogen compound#GO:1901698;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;cellular process#GO:0009987;defense response to symbiont#GO:0140546;lymphocyte activation involved in immune response#GO:0002285;signal transduction#GO:0007165;defense response to other organism#GO:0098542;response to chemical#GO:0042221;lymphocyte activation#GO:0046649;response to cytokine#GO:0034097;T cell activation involved in immune response#GO:0002286;humoral immune response#GO:0006959;cell surface receptor signaling pathway#GO:0007166;leukocyte activation involved in immune response#GO:0002366;immune effector process#GO:0002252;natural killer cell activation#GO:0030101;B cell activation#GO:0042113;T cell activation#GO:0042110;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052;B cell activation involved in immune response#GO:0002312;type I interferon-mediated signaling pathway#GO:0060337;immune system process#GO:0002376;cell activation involved in immune response#GO:0002263;response to peptide#GO:1901652 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 cytokine#PC00083;interferon superfamily#PC00127 HUMAN|HGNC=10722|UniProtKB=Q14242 Q14242 SELPLG PTHR17384:SF7 P-SELECTIN GLYCOPROTEIN LIGAND-1 P-SELECTIN GLYCOPROTEIN LIGAND 1 cell adhesion#GO:0007155;leukocyte migration#GO:0050900;immune system process#GO:0002376;cell migration#GO:0016477;cell motility#GO:0048870;leukocyte cell-cell adhesion#GO:0007159;cellular process#GO:0009987;cell-cell adhesion#GO:0098609 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HUMAN|HGNC=7638|UniProtKB=Q9ULW6 Q9ULW6 NAP1L2 PTHR11875:SF36 TESTIS-SPECIFIC Y-ENCODED PROTEIN NUCLEOSOME ASSEMBLY PROTEIN 1-LIKE 2 binding#GO:0005488;chromatin binding#GO:0003682;histone binding#GO:0042393;protein binding#GO:0005515 nucleosome organization#GO:0034728;protein-DNA complex organization#GO:0071824;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;cellular component assembly#GO:0022607;chromatin remodeling#GO:0006338;protein-DNA complex assembly#GO:0065004;chromatin organization#GO:0006325;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003 membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;chromatin#GO:0000785;nucleus#GO:0005634 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=33865|UniProtKB=Q6ZT21 Q6ZT21 TMPPE PTHR31302:SF0 TRANSMEMBRANE PROTEIN WITH METALLOPHOSPHOESTERASE DOMAIN-RELATED TRANSMEMBRANE PROTEIN WITH METALLOPHOSPHOESTERASE DOMAIN HUMAN|HGNC=10008|UniProtKB=P18577 P18577 RHCE PTHR11730:SF100 AMMONIUM TRANSPORTER BLOOD GROUP RH(CE) POLYPEPTIDE channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 nitrogen compound transport#GO:0071705;cellular process#GO:0009987;homeostatic process#GO:0042592;inorganic ion homeostasis#GO:0098771;chemical homeostasis#GO:0048878;transport#GO:0006810;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227;primary active transporter#PC00068 HUMAN|HGNC=14075|UniProtKB=Q96LD1 Q96LD1 SGCZ PTHR12939:SF5 SARCOGLYCAN ZETA-SARCOGLYCAN circulatory system development#GO:0072359;heart process#GO:0003015;muscle tissue development#GO:0060537;system development#GO:0048731;anatomical structure development#GO:0048856;circulatory system process#GO:0003013;animal gross anatomical part developmental process#GO:0160108;multicellular organismal process#GO:0032501;tissue development#GO:0009888;blood circulation#GO:0008015;heart development#GO:0007507;system process#GO:0003008;heart contraction#GO:0060047;cardiac muscle tissue development#GO:0048738;animal organ development#GO:0048513;multicellular organism development#GO:0007275;striated muscle tissue development#GO:0014706;developmental process#GO:0032502 membrane#GO:0016020;dystrophin-associated glycoprotein complex#GO:0016010;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;sarcolemma#GO:0042383 cytoskeletal protein#PC00085 HUMAN|HGNC=24513|UniProtKB=Q5VZI3 Q5VZI3 TMEM268 PTHR31193:SF1 TRANSMEMBRANE PROTEIN C9ORF91 TRANSMEMBRANE PROTEIN 268 HUMAN|HGNC=18553|UniProtKB=Q9Y342 Q9Y342 PLLP PTHR22776:SF9 MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN PLASMOLIPIN anatomical structure formation involved in morphogenesis#GO:0048646;myelination#GO:0042552;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;developmental process#GO:0032502;cellular anatomical entity morphogenesis#GO:0032989;biological regulation#GO:0065007;nervous system development#GO:0007399;cellular component assembly#GO:0022607;multicellular organismal process#GO:0032501;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;system development#GO:0048731;anatomical structure development#GO:0048856;animal gross anatomical part developmental process#GO:0160108;cellular component assembly involved in morphogenesis#GO:0010927;signaling#GO:0023052;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043 cell periphery#GO:0071944;apical plasma membrane#GO:0016324;membrane#GO:0016020;plasma membrane#GO:0005886;myelin sheath#GO:0043209;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;apical part of cell#GO:0045177 scaffold/adaptor protein#PC00226 HUMAN|Ensembl=ENSG00000284476.2|UniProtKB=A0A1W2PRE2 A0A1W2PRE2 PTHR11667:SF27 FAMILY NOT NAMED ADENYLATE KINASE HUMAN|HGNC=2153|UniProtKB=Q9NQW8 Q9NQW8 CNGB3 PTHR45638:SF8 CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A CYCLIC NUCLEOTIDE-GATED CHANNEL BETA-3 binding#GO:0005488;nucleoside phosphate binding#GO:1901265;guanyl nucleotide binding#GO:0019001;gated channel activity#GO:0022836;monoatomic cation transmembrane transporter activity#GO:0008324;guanyl ribonucleotide binding#GO:0032561;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;transporter activity#GO:0005215;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167;ligand-gated monoatomic ion channel activity#GO:0015276;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261;nucleotide binding#GO:0000166 establishment of localization#GO:0051234;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;transport#GO:0006810;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;cellular process#GO:0009987 cation channel complex#GO:0034703;transporter complex#GO:1990351;cell periphery#GO:0071944;photoreceptor cell cilium#GO:0097733;neuron projection#GO:0043005;membrane#GO:0016020;9+0 non-motile cilium#GO:0097731;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;cilium#GO:0005929;non-motile cilium#GO:0097730;membrane-bounded organelle#GO:0043227;transmembrane transporter complex#GO:1902495;membrane protein complex#GO:0098796;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;photoreceptor outer segment#GO:0001750 ion channel#PC00133;ligand-gated ion channel#PC00141 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>cGMP-gated ion channel#P00752 HUMAN|HGNC=8881|UniProtKB=P07737 P07737 PFN1 PTHR13936:SF14 PROFILIN PROFILIN-1 protein binding#GO:0005515;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;binding#GO:0005488 positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of actin filament organization#GO:0110053;cellular process#GO:0009987;biological regulation#GO:0065007;regulation of actin polymerization or depolymerization#GO:0008064;regulation of actin cytoskeleton organization#GO:0032956;regulation of actin filament polymerization#GO:0030833;positive regulation of cellular component biogenesis#GO:0044089;regulation of anatomical structure size#GO:0090066;regulation of actin filament-based process#GO:0032970;positive regulation of actin filament bundle assembly#GO:0032233;cellular component organization or biogenesis#GO:0071840;regulation of biological process#GO:0050789;regulation of supramolecular fiber organization#GO:1902903;regulation of cellular component size#GO:0032535;regulation of organelle organization#GO:0033043;regulation of actin filament bundle assembly#GO:0032231;regulation of protein-containing complex assembly#GO:0043254;cellular component organization#GO:0016043;regulation of stress fiber assembly#GO:0051492;regulation of cellular component biogenesis#GO:0044087;regulation of cellular component organization#GO:0051128;regulation of protein polymerization#GO:0032271;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794;positive regulation of cellular component organization#GO:0051130;regulation of actin filament length#GO:0030832;regulation of biological quality#GO:0065008;positive regulation of organelle organization#GO:0010638 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 non-motor actin binding protein#PC00165;actin or actin-binding cytoskeletal protein#PC00041 Cytoskeletal regulation by Rho GTPase#P00016>Profilin#P00521 HUMAN|HGNC=20864|UniProtKB=Q7Z769 Q7Z769 SLC35E3 PTHR11132:SF250 SOLUTE CARRIER FAMILY 35 SOLUTE CARRIER FAMILY 35 MEMBER E3 active transmembrane transporter activity#GO:0022804;antiporter activity#GO:0015297;secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;organophosphate ester transmembrane transporter activity#GO:0015605;nucleobase-containing compound transmembrane transporter activity#GO:0015932;carbohydrate derivative transmembrane transporter activity#GO:1901505;nucleotide-sugar transmembrane transporter activity#GO:0005338 transport#GO:0006810;cellular process#GO:0009987;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234 membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular organelle#GO:0043229;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227 secondary carrier transporter#PC00258;transporter#PC00227 HUMAN|HGNC=8222|UniProtKB=Q8NH06 Q8NH06 OR1P1 PTHR48001:SF42 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 1P1 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=21206|UniProtKB=P0C6S8 P0C6S8 LINGO3 PTHR24373:SF130 SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN LEUCINE-RICH REPEAT AND IMMUNOGLOBULIN-LIKE DOMAIN-CONTAINING NOGO RECEPTOR-INTERACTING PROTEIN 3 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=2483|UniProtKB=Q05048 Q05048 CSTF1 PTHR44133:SF2 CLEAVAGE STIMULATION FACTOR SUBUNIT 1 CLEAVAGE STIMULATION FACTOR SUBUNIT 1 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;mRNA cleavage factor complex#GO:0005849;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=21296|UniProtKB=Q9H6S3 Q9H6S3 EPS8L2 PTHR12287:SF20 EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8-RELATED PROTEIN EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE 8-LIKE PROTEIN 2 protein binding#GO:0005515;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;binding#GO:0005488 regulation of intracellular signal transduction#GO:1902531;positive regulation of cell projection organization#GO:0031346;regulation of signaling#GO:0023051;positive regulation of cellular component organization#GO:0051130;Rho protein signal transduction#GO:0007266;cell communication#GO:0007154;regulation of cell projection assembly#GO:0060491;intracellular signal transduction#GO:0035556;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of Rho protein signal transduction#GO:0035023;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;regulation of plasma membrane bounded cell projection assembly#GO:0120032;regulation of cell communication#GO:0010646;regulation of cellular component biogenesis#GO:0044087;signaling#GO:0023052;regulation of cell projection organization#GO:0031344;regulation of response to stimulus#GO:0048583;regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of small GTPase mediated signal transduction#GO:0051056;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;positive regulation of cellular component biogenesis#GO:0044089;intracellular signaling cassette#GO:0141124;regulation of signal transduction#GO:0009966;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007 membrane#GO:0016020;cell leading edge#GO:0031252;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;plasma membrane#GO:0005886;ruffle membrane#GO:0032587;leading edge membrane#GO:0031256;ruffle#GO:0001726;cell projection membrane#GO:0031253 scaffold/adaptor protein#PC00226 HUMAN|HGNC=4602|UniProtKB=P09341 P09341 CXCL1 PTHR12015:SF192 SMALL INDUCIBLE CYTOKINE A GROWTH-REGULATED ALPHA PROTEIN cytokine#PC00083 CCKR signaling map#P06959>CXCL1#G07268;CCKR signaling map#P06959>CXCL1#G06975 HUMAN|HGNC=15532|UniProtKB=Q9BX67 Q9BX67 JAM3 PTHR44598:SF2 JUNCTIONAL ADHESION MOLECULE C JUNCTIONAL ADHESION MOLECULE C cell adhesion molecule#PC00069 HUMAN|HGNC=19854|UniProtKB=Q96MY7 Q96MY7 FAM161B PTHR21501:SF4 PROTEIN FAM-161 PROTEIN FAM161B plasma membrane bounded cell projection organization#GO:0120036;cilium organization#GO:0044782;cellular component organization or biogenesis#GO:0071840;cell projection organization#GO:0030030;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043 HUMAN|HGNC=11257|UniProtKB=P35270 P35270 SPR PTHR44085:SF2 SEPIAPTERIN REDUCTASE SEPIAPTERIN REDUCTASE oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 biosynthetic process#GO:0009058;small molecule metabolic process#GO:0044281;pteridine-containing compound metabolic process#GO:0042558;alcohol biosynthetic process#GO:0046165;cellular process#GO:0009987;small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152;alcohol metabolic process#GO:0006066 reductase#PC00198 HUMAN|HGNC=21517|UniProtKB=O95620 O95620 DUS4L PTHR11082:SF31 TRNA-DIHYDROURIDINE SYNTHASE TRNA-DIHYDROURIDINE(20A_20B) SYNTHASE [NAD(P)+]-LIKE oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640 RNA processing factor#PC00147 HUMAN|HGNC=30790|UniProtKB=Q96PF1 Q96PF1 TGM7 PTHR11590:SF41 PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE Z aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824 transferase#PC00220 HUMAN|HGNC=32331|UniProtKB=Q5T5A4 Q5T5A4 CFAP276 PTHR48619:SF1 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 276 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 276 HUMAN|HGNC=9017|UniProtKB=P61925 P61925 PKIA PTHR15416:SF2 CAMP-DEPENDENT PROTEIN KINASE INHIBITOR/PKI CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;kinase inhibitor activity#GO:0019210;protein kinase inhibitor activity#GO:0004860;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;protein kinase regulator activity#GO:0019887;enzyme inhibitor activity#GO:0004857 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 kinase modulator#PC00140;kinase inhibitor#PC00139 HUMAN|HGNC=20886|UniProtKB=Q9NUQ2 Q9NUQ2 AGPAT5 PTHR10983:SF73 1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED 1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE EPSILON transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746 cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;phospholipid metabolic process#GO:0006644;glycerophospholipid metabolic process#GO:0006650;glycerolipid metabolic process#GO:0046486;phosphatidylinositol metabolic process#GO:0046488;lipid metabolic process#GO:0006629;metabolic process#GO:0008152 mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 acyltransferase#PC00042;transferase#PC00220 HUMAN|HGNC=23468|UniProtKB=Q96IM9 Q96IM9 DYDC2 PTHR23356:SF3 DPY30-RELATED DPY30 DOMAIN-CONTAINING PROTEIN 2 cilium#GO:0005929;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;axoneme#GO:0005930;membraneless organelle#GO:0043228;intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;ciliary plasm#GO:0097014 HUMAN|HGNC=9400|UniProtKB=Q969G5 Q969G5 CAVIN3 PTHR15240:SF2 CAVIN CAVEOLAE-ASSOCIATED PROTEIN 3 enzyme binding#GO:0019899;protein kinase binding#GO:0019901;kinase binding#GO:0019900;binding#GO:0005488;protein binding#GO:0005515 intracellular anatomical structure#GO:0005622;plasma membrane raft#GO:0044853;membrane microdomain#GO:0098857;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;cell periphery#GO:0071944;membrane#GO:0016020;membrane raft#GO:0045121;caveola#GO:0005901 membrane traffic protein#PC00150 HUMAN|HGNC=48329|UniProtKB=K7EJ46 K7EJ46 SMIM22 PTHR36982:SF3 CLCA DOMAIN-CONTAINING PROTEIN SMALL INTEGRAL MEMBRANE PROTEIN 22 biological regulation#GO:0065007;regulation of cell population proliferation#GO:0042127;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789 HUMAN|HGNC=32257|UniProtKB=A6NNJ1 A6NNJ1 FAM90A9 PTHR16035:SF14 PROTEIN FAM90A1 PROTEIN FAM90A10-RELATED HUMAN|HGNC=35466|UniProtKB=Q495Y7 Q495Y7 SPDYE7P PTHR31156:SF15 WBSCR19-LIKE PROTEIN SPEEDY PROTEIN E10-RELATED HUMAN|HGNC=32017|UniProtKB=Q08AH3 Q08AH3 ACSM2A PTHR43605:SF14 ACYL-COENZYME A SYNTHETASE ACYL-COENZYME A SYNTHETASE ACSM2A, MITOCHONDRIAL acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;ATP-dependent activity#GO:0140657;ligase activity#GO:0016874;ligase activity, forming carbon-sulfur bonds#GO:0016877;acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824 lipid biosynthetic process#GO:0008610;nucleobase-containing compound metabolic process#GO:0006139;fatty acid biosynthetic process#GO:0006633;biosynthetic process#GO:0009058;sulfur compound metabolic process#GO:0006790;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;monocarboxylic acid biosynthetic process#GO:0072330;nucleobase-containing small molecule metabolic process#GO:0055086;acyl-CoA metabolic process#GO:0006637;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;phosphorus metabolic process#GO:0006793;monocarboxylic acid metabolic process#GO:0032787;purine-containing compound metabolic process#GO:0072521;carboxylic acid biosynthetic process#GO:0046394;oxoacid metabolic process#GO:0043436 mitochondrion#GO:0005739;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 metabolite interconversion enzyme#PC00262;ligase#PC00142 HUMAN|HGNC=5017|UniProtKB=Q9NP08 Q9NP08 HMX1 PTHR46110:SF1 HOMEOBOX PROTEIN HMX HOMEOBOX PROTEIN HMX1 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 HUMAN|HGNC=25937|UniProtKB=Q6IPW1 Q6IPW1 C11orf71 PTHR16445:SF0 SIMILAR TO HYPOTHETICAL PROTEIN FLJ20010 SIMILAR TO HUMAN CHROMOSOME 11 OPEN READING FRAME 71 HUMAN|HGNC=23147|UniProtKB=Q70J99 Q70J99 UNC13D PTHR45999:SF3 UNC-13-4A, ISOFORM B PROTEIN UNC-13 HOMOLOG D transport#GO:0006810;establishment of localization#GO:0051234;secretion#GO:0046903;localization#GO:0051179 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;transport vesicle#GO:0030133;vesicle#GO:0031982;secretory vesicle#GO:0099503;intracellular vesicle#GO:0097708;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229 Synaptic vesicle trafficking#P05734>Munc13#P05773 HUMAN|HGNC=15191|UniProtKB=A0A3B3IT45 A0A3B3IT45 OR51C1 PTHR26450:SF408 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR OR51C1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=21496|UniProtKB=P53367 P53367 ARFIP1 PTHR12141:SF4 ARFAPTIN-RELATED ARFAPTIN-1 molecular function regulator activity#GO:0098772;molecular sensor activity#GO:0140299 regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of supramolecular fiber organization#GO:1902903;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;localization#GO:0051179;cellular localization#GO:0051641;protein transport#GO:0015031;biological regulation#GO:0065007;regulation of actin cytoskeleton organization#GO:0032956;macromolecule localization#GO:0033036;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;regulation of actin filament organization#GO:0110053;cellular process#GO:0009987;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;regulation of actin nucleation#GO:0051125;intracellular transport#GO:0046907;regulation of actin filament-based process#GO:0032970;intracellular protein transport#GO:0006886;transport#GO:0006810 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;trans-Golgi network membrane#GO:0032588;organelle#GO:0043226;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 vesicle coat protein#PC00235 HUMAN|HGNC=18894|UniProtKB=Q8WTR2 Q8WTR2 DUSP19 PTHR46377:SF1 DUAL SPECIFICITY PROTEIN PHOSPHATASE 19 DUAL SPECIFICITY PROTEIN PHOSPHATASE 19 hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721;protein tyrosine/serine/threonine phosphatase activity#GO:0008138;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096 regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of biological process#GO:0050789;regulation of JNK cascade#GO:0046328;regulation of intracellular signal transduction#GO:1902531;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;regulation of MAPK cascade#GO:0043408 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protein phosphatase#PC00195 Oxidative stress response#P00046>MKP5#P01131 HUMAN|HGNC=1568|UniProtKB=Q13939 Q13939 CCIN PTHR24412:SF163 KELCH PROTEIN CALICIN ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;ubiquitin ligase complex#GO:0000151;Cul3-RING ubiquitin ligase complex#GO:0031463;catalytic complex#GO:1902494;transferase complex#GO:1990234;cytoplasm#GO:0005737;cullin-RING ubiquitin ligase complex#GO:0031461;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=20486|UniProtKB=Q8NBM4 Q8NBM4 UBAC2 PTHR43066:SF28 RHOMBOID-RELATED PROTEIN UBIQUITIN-ASSOCIATED DOMAIN-CONTAINING PROTEIN 2 catalytic activity#GO:0003824;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;serine-type peptidase activity#GO:0008236;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787 serine protease#PC00203;protease#PC00190;protein modifying enzyme#PC00260 HUMAN|HGNC=22412|UniProtKB=Q8N0U4 Q8N0U4 FAM185A PTHR34094:SF1 FAMILY NOT NAMED PROTEIN FAM185A HUMAN|HGNC=10593|UniProtKB=Q14524 Q14524 SCN5A PTHR10037:SF206 VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM SODIUM CHANNEL PROTEIN TYPE 5 SUBUNIT ALPHA channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;sodium channel activity#GO:0005272;passive transmembrane transporter activity#GO:0022803;voltage-gated sodium channel activity#GO:0005248;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216 sensory perception of pain#GO:0019233;sodium ion transport#GO:0006814;regulation of biological process#GO:0050789;action potential#GO:0001508;regulation of cellular process#GO:0050794;regulation of heart contraction#GO:0008016;metal ion transport#GO:0030001;membrane depolarization#GO:0051899;nervous system process#GO:0050877;sensory perception#GO:0007600;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;multicellular organismal process#GO:0032501;monoatomic ion transmembrane transport#GO:0034220;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;monoatomic cation transmembrane transport#GO:0098655;regulation of system process#GO:0044057;transport#GO:0006810;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;system process#GO:0003008 transporter complex#GO:1990351;cation channel complex#GO:0034703;plasma membrane#GO:0005886;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;cell periphery#GO:0071944;neuron projection#GO:0043005;membrane#GO:0016020;sodium channel complex#GO:0034706;transmembrane transporter complex#GO:1902495;axon#GO:0030424;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796 voltage-gated ion channel#PC00241 HUMAN|HGNC=28848|UniProtKB=Q9NQ92 Q9NQ92 COPRS PTHR36461:SF1 COORDINATOR OF PRMT5 AND DIFFERENTIATION STIMULATOR COORDINATOR OF PRMT5 AND DIFFERENTIATION STIMULATOR binding#GO:0005488;histone binding#GO:0042393;protein binding#GO:0005515 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=27030|UniProtKB=Q5F1R6 Q5F1R6 DNAJC21 PTHR44029:SF1 DNAJ HOMOLOG SUBFAMILY C MEMBER 21 DNAJ HOMOLOG SUBFAMILY C MEMBER 21 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 chaperone#PC00072 HUMAN|HGNC=6444|UniProtKB=P04259 P04259 KRT6B PTHR45616:SF39 GATA-TYPE DOMAIN-CONTAINING PROTEIN KERATIN, TYPE II CYTOSKELETAL 6A-RELATED structural molecule activity#GO:0005198 epithelium development#GO:0060429;multicellular organismal process#GO:0032501;epidermal cell differentiation#GO:0009913;tissue development#GO:0009888;epithelial cell differentiation#GO:0030855;skin development#GO:0043588;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;animal organ development#GO:0048513;epidermis development#GO:0008544;developmental process#GO:0032502;cell differentiation#GO:0030154;intermediate filament cytoskeleton organization#GO:0045104;cellular component organization#GO:0016043;anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;intermediate filament-based process#GO:0045103;keratinocyte differentiation#GO:0030216;animal gross anatomical part developmental process#GO:0160108;intermediate filament organization#GO:0045109 intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;supramolecular complex#GO:0099080;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intermediate filament#GO:0005882;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228 HUMAN|HGNC=20653|UniProtKB=Q8IVB4 Q8IVB4 SLC9A9 PTHR10110:SF61 SODIUM/HYDROGEN EXCHANGER SODIUM_HYDROGEN EXCHANGER 9 potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;metal cation:proton antiporter activity#GO:0051139;monoatomic ion transmembrane transporter activity#GO:0015075;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;proton transmembrane transporter activity#GO:0015078;antiporter activity#GO:0015297;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;secondary active transmembrane transporter activity#GO:0015291 sodium ion transport#GO:0006814;intracellular monoatomic ion homeostasis#GO:0006873;inorganic ion import across plasma membrane#GO:0099587;metal ion transport#GO:0030001;homeostatic process#GO:0042592;import across plasma membrane#GO:0098739;regulation of intracellular pH#GO:0051453;regulation of pH#GO:0006885;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;monoatomic ion homeostasis#GO:0050801;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;potassium ion transport#GO:0006813;intracellular monoatomic cation homeostasis#GO:0030003;transport#GO:0006810;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;inorganic cation import across plasma membrane#GO:0098659;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;import into cell#GO:0098657;establishment of localization#GO:0051234 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endosome#GO:0005768;plasma membrane#GO:0005886;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cell periphery#GO:0071944;membrane#GO:0016020;recycling endosome#GO:0055037 secondary carrier transporter#PC00258 HUMAN|HGNC=6729|UniProtKB=O60449 O60449 LY75 PTHR22803:SF65 MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED LYMPHOCYTE ANTIGEN 75 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 cellular process#GO:0009987;endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;transport#GO:0006810;import into cell#GO:0098657;establishment of localization#GO:0051234;localization#GO:0051179;receptor-mediated endocytosis#GO:0006898 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=4197|UniProtKB=Q9NP62 Q9NP62 GCM1 PTHR12414:SF6 GLIAL CELLS MISSING RELATED/GLIDE CHORION-SPECIFIC TRANSCRIPTION FACTOR GCMA double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;chordate embryonic development#GO:0043009;animal gross anatomical part developmental process#GO:0160108;cellular process#GO:0009987;nervous system development#GO:0007399;embryo development#GO:0009790;placenta development#GO:0001890;gliogenesis#GO:0042063;animal organ development#GO:0048513;multicellular organism development#GO:0007275;developmental process involved in reproduction#GO:0003006;reproductive process#GO:0022414;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;embryonic organ development#GO:0048568;embryo development ending in birth or egg hatching#GO:0009792;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;developmental process#GO:0032502;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=28842|UniProtKB=Q9BQ04 Q9BQ04 RBM4B PTHR23147:SF80 SERINE/ARGININE RICH SPLICING FACTOR RNA-BINDING PROTEIN 4B rhythmic process#GO:0048511;circadian rhythm#GO:0007623 membraneless organelle#GO:0043228;nuclear body#GO:0016604;intracellular membraneless organelle#GO:0043232;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear speck#GO:0016607;organelle lumen#GO:0043233 RNA processing factor#PC00147;RNA splicing factor#PC00148;RNA metabolism protein#PC00031 HUMAN|HGNC=24510|UniProtKB=Q4KMP7 Q4KMP7 TBC1D10B PTHR22957:SF207 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN TBC1 DOMAIN FAMILY MEMBER 10B molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme activator activity#GO:0008047 localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;endosomal transport#GO:0016197;intracellular transport#GO:0046907;transport#GO:0006810;vesicle-mediated transport#GO:0016192;cytosolic transport#GO:0016482;retrograde transport, endosome to Golgi#GO:0042147;establishment of localization in cell#GO:0051649;cellular process#GO:0009987 GTPase-activating protein#PC00257;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HUMAN|HGNC=392|UniProtKB=P31751 P31751 AKT2 PTHR24356:SF176 SERINE/THREONINE-PROTEIN KINASE RAC-BETA SERINE_THREONINE-PROTEIN KINASE catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;regulation of cell motility#GO:2000145;intracellular signal transduction#GO:0035556;response to nitrogen compound#GO:1901698;cellular response to stimulus#GO:0051716;response to insulin#GO:0032868;regulation of cellular process#GO:0050794;cellular response to peptide hormone stimulus#GO:0071375;negative regulation of cellular process#GO:0048523;cellular response to insulin stimulus#GO:0032869;regulation of cell migration#GO:0030334;positive regulation of locomotion#GO:0040017;positive regulation of cell migration#GO:0030335;positive regulation of cellular process#GO:0048522;cellular response to nitrogen compound#GO:1901699;negative regulation of apoptotic process#GO:0043066;regulation of locomotion#GO:0040012;response to peptide hormone#GO:0043434;biological regulation#GO:0065007;cellular response to chemical stimulus#GO:0070887;response to oxygen-containing compound#GO:1901700;insulin receptor signaling pathway#GO:0008286;negative regulation of biological process#GO:0048519;response to endogenous stimulus#GO:0009719;regulation of programmed cell death#GO:0043067;positive regulation of cell motility#GO:2000147;regulation of biological process#GO:0050789;cellular response to hormone stimulus#GO:0032870;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;signaling#GO:0023052;cell surface receptor signaling pathway#GO:0007166;regulation of apoptotic process#GO:0042981;response to hormone#GO:0009725;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular response to oxygen-containing compound#GO:1901701;negative regulation of programmed cell death#GO:0043069;response to chemical#GO:0042221 non-receptor serine/threonine protein kinase#PC00167 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>AKT#P00827;PI3 kinase pathway#P00048>PKB#P01179;EGF receptor signaling pathway#P00018>Akt#P00551;Hypoxia response via HIF activation#P00030>AKT#P00819;Huntington disease#P00029>Akt#P00805;Angiogenesis#P00005>Akt#P00223;Endothelin signaling pathway#P00019>Akt#P00589;FGF signaling pathway#P00021>Akt#P00632;PDGF signaling pathway#P00047>PKB#P01151;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>AKT#P00894;Apoptosis signaling pathway#P00006>AKT#P00260;Interleukin signaling pathway#P00036>PKB#P00973;p53 pathway feedback loops 2#P04398>AKT#P04665;T cell activation#P00053>Akt#P01332;p53 pathway by glucose deprivation#P04397>Akt#P04641;FAS signaling pathway#P00020>ASK1#P00614;p53 pathway#P00059>Akt#P01486 HUMAN|HGNC=10664|UniProtKB=Q6UX04 Q6UX04 CWC27 PTHR45625:SF6 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED SPLICEOSOME-ASSOCIATED PROTEIN CWC27 HOMOLOG cis-trans isomerase activity#GO:0016859;peptidyl-prolyl cis-trans isomerase activity#GO:0003755;isomerase activity#GO:0016853;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 spliceosomal complex#GO:0005681;nucleus#GO:0005634;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;catalytic step 2 spliceosome#GO:0071013;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 chaperone#PC00072 HUMAN|HGNC=3723|UniProtKB=Q9Y680 Q9Y680 FKBP7 PTHR46222:SF2 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP7/14 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP7 chaperone#PC00072 HUMAN|HGNC=29598|UniProtKB=Q9BQ69 Q9BQ69 MACROD1 PTHR11106:SF93 GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED ADP-RIBOSE GLYCOHYDROLASE MACROD1 hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 metabolic process#GO:0008152;purine nucleoside metabolic process#GO:0042278;DNA damage response#GO:0006974;cellular response to stress#GO:0033554;nucleobase-containing small molecule metabolic process#GO:0055086;response to stress#GO:0006950;primary metabolic process#GO:0044238;cellular process#GO:0009987;purine-containing compound metabolic process#GO:0072521;cellular response to stimulus#GO:0051716;carbohydrate derivative metabolic process#GO:1901135;nucleoside metabolic process#GO:0009116;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 HUMAN|HGNC=10613|UniProtKB=Q16663 Q16663 CCL15 PTHR12015:SF77 SMALL INDUCIBLE CYTOKINE A C-C MOTIF CHEMOKINE 15 signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;chemokine activity#GO:0008009;G protein-coupled receptor binding#GO:0001664;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;cytokine activity#GO:0005125;binding#GO:0005488;signaling receptor binding#GO:0005102;cytokine receptor binding#GO:0005126;protein binding#GO:0005515;chemokine receptor binding#GO:0042379;molecular function activator activity#GO:0140677 positive regulation of biological process#GO:0048518;defense response to symbiont#GO:0140546;signal transduction#GO:0007165;cellular process#GO:0009987;response to chemokine#GO:1990868;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;response to cytokine#GO:0034097;response to chemical#GO:0042221;taxis#GO:0042330;granulocyte migration#GO:0097530;defense response to other organism#GO:0098542;cell surface receptor signaling pathway#GO:0007166;humoral immune response#GO:0006959;antimicrobial humoral response#GO:0019730;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;positive regulation of cell motility#GO:2000147;biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052;granulocyte chemotaxis#GO:0071621;response to stimulus#GO:0050896;immune system process#GO:0002376;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;response to peptide#GO:1901652;immune response#GO:0006955;positive regulation of cellular process#GO:0048522;positive regulation of cell migration#GO:0030335;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;response to other organism#GO:0051707;cell migration#GO:0016477;regulation of cell migration#GO:0030334;leukocyte migration#GO:0050900;positive regulation of locomotion#GO:0040017;myeloid leukocyte migration#GO:0097529;response to external stimulus#GO:0009605;defense response#GO:0006952;leukocyte chemotaxis#GO:0030595;cellular response to stimulus#GO:0051716;response to external biotic stimulus#GO:0043207;locomotion#GO:0040011;cellular response to chemokine#GO:1990869;cell motility#GO:0048870;regulation of cellular process#GO:0050794;chemotaxis#GO:0006935;inflammatory response#GO:0006954;cytokine-mediated signaling pathway#GO:0019221;cell chemotaxis#GO:0060326;regulation of cell motility#GO:2000145;cell communication#GO:0007154;chemokine-mediated signaling pathway#GO:0070098;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 cytokine#PC00083 HUMAN|HGNC=10450|UniProtKB=O14718 O14718 RRH PTHR24240:SF77 OPSIN VISUAL PIGMENT-LIKE RECEPTOR PEROPSIN transmembrane signaling receptor activity#GO:0004888;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to abiotic stimulus#GO:0009628;cellular response to radiation#GO:0071478;signaling#GO:0023052;response to light stimulus#GO:0009416;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cellular response to environmental stimulus#GO:0104004;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;signal transduction#GO:0007165;cellular process#GO:0009987;response to radiation#GO:0009314;cellular response to light stimulus#GO:0071482;detection of stimulus#GO:0051606;biological regulation#GO:0065007;response to external stimulus#GO:0009605;cellular response to abiotic stimulus#GO:0071214 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021 HUMAN|HGNC=5386|UniProtKB=P51553 P51553 IDH3G PTHR11835:SF78 DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT GAMMA, MITOCHONDRIAL catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614 cellular process#GO:0009987;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;tricarboxylic acid cycle#GO:0006099;secondary alcohol metabolic process#GO:1902652;small molecule metabolic process#GO:0044281;generation of precursor metabolites and energy#GO:0006091;alcohol metabolic process#GO:0006066;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;aerobic respiration#GO:0009060;cellular respiration#GO:0045333;energy derivation by oxidation of organic compounds#GO:0015980 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739 oxidoreductase#PC00176;dehydrogenase#PC00092 HUMAN|HGNC=21022|UniProtKB=Q5JTZ9 Q5JTZ9 AARS2 PTHR11777:SF8 ALANYL-TRNA SYNTHETASE ALANINE--TRNA LIGASE, MITOCHONDRIAL catalytic activity, acting on a tRNA#GO:0140101;hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689;catalytic activity, acting on RNA#GO:0140098;ligase activity#GO:0016874;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on a nucleic acid#GO:0140640;deacylase activity#GO:0160215;catalytic activity#GO:0003824 tRNA aminoacylation#GO:0043039;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;tRNA aminoacylation for protein translation#GO:0006418;gene expression#GO:0010467;amino acid metabolic process#GO:0006520;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;amino acid activation#GO:0043038;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;protein biosynthetic process#GO:0160307;translation#GO:0006412;RNA metabolic process#GO:0016070;protein metabolic process#GO:0019538 aminoacyl-tRNA synthetase#PC00047 HUMAN|HGNC=6738|UniProtKB=O95372 O95372 LYPLA2 PTHR10655:SF13 LYSOPHOSPHOLIPASE-RELATED ACYL-PROTEIN THIOESTERASE 2 catalytic activity, acting on a protein#GO:0140096;glycerophospholipase activity#GO:0004620;catalytic activity#GO:0003824;phospholipase activity#GO:0120569;hydrolase activity, acting on ester bonds#GO:0016788;palmitoyl hydrolase activity#GO:0098599;hydrolase activity#GO:0016787;phosphatidylcholine lysophospholipase A1 activity#GO:0004622;lipase activity#GO:0016298;carboxylic ester hydrolase activity#GO:0052689;thiolester hydrolase activity#GO:0016790 regulation of establishment of protein localization#GO:0070201;regulation of protein localization#GO:0032880;regulation of protein transport#GO:0051223;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;negative regulation of transport#GO:0051051;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;primary metabolic process#GO:0044238;negative regulation of biological process#GO:0048519;regulation of transport#GO:0051049;regulation of localization#GO:0032879;lipid metabolic process#GO:0006629;negative regulation of cellular process#GO:0048523;metabolic process#GO:0008152;negative regulation of protein transport#GO:0051224;biological regulation#GO:0065007;cellular process#GO:0009987;regulation of protein localization to membrane#GO:1905475;lipid catabolic process#GO:0016042 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 phospholipase#PC00186;lipase#PC00143 HUMAN|HGNC=14637|UniProtKB=Q86UK0 Q86UK0 ABCA12 PTHR19229:SF29 ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA GLUCOSYLCERAMIDE TRANSPORTER ABCA12 active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;protein binding#GO:0005515;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626;molecular carrier activity#GO:0140104;lipid carrier activity#GO:0005319;signaling receptor binding#GO:0005102;binding#GO:0005488 localization#GO:0051179;lipid transport#GO:0006869;establishment of localization#GO:0051234;macromolecule localization#GO:0033036;lipid localization#GO:0010876;transport#GO:0006810 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229 ATP-binding cassette (ABC) transporter#PC00003 HUMAN|HGNC=4635|UniProtKB=P21266 P21266 GSTM3 PTHR11571:SF222 GLUTATHIONE S-TRANSFERASE GLUTATHIONE S-TRANSFERASE MU 3 transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;glutathione transferase activity#GO:0004364;catalytic activity#GO:0003824;transferase activity#GO:0016740 cellular process#GO:0009987;glutathione metabolic process#GO:0006749;modified amino acid metabolic process#GO:0006575;sulfur compound metabolic process#GO:0006790;metabolic process#GO:0008152 transferase#PC00220 HUMAN|HGNC=20710|UniProtKB=Q9BTP6 Q9BTP6 ZBED2 PTHR35827:SF1 ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 3 ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 2 transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription repressor activity#GO:0001217;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 negative regulation of biological process#GO:0048519;positive regulation of multicellular organismal process#GO:0051240;regulation of multicellular organismal development#GO:2000026;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of epithelial cell differentiation#GO:0030856;negative regulation of macromolecule biosynthetic process#GO:0010558;positive regulation of biological process#GO:0048518;regulation of multicellular organismal process#GO:0051239;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;positive regulation of cell differentiation#GO:0045597;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of developmental process#GO:0050793;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;negative regulation of cellular process#GO:0048523;regulation of cell differentiation#GO:0045595;positive regulation of developmental process#GO:0051094;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=28790|UniProtKB=Q9BVG4 Q9BVG4 PBDC1 PTHR13410:SF9 PROTEIN PBDC1 PROTEIN PBDC1 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;protein folding#GO:0006457;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238 HUMAN|HGNC=15221|UniProtKB=Q8NH67 Q8NH67 OR52I2 PTHR26450:SF177 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 52I1-RELATED olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=28301|UniProtKB=Q6PKX4 Q6PKX4 DOK6 PTHR21258:SF43 DOCKING PROTEIN RELATED DOCKING PROTEIN 6 scaffold/adaptor protein#PC00226 HUMAN|HGNC=38603|UniProtKB=P0C874 P0C874 SPATA31D3 PTHR21859:SF50 ACROSOME-SPECIFIC PROTEIN SPERMATOGENESIS-ASSOCIATED PROTEIN 31D3-RELATED HUMAN|HGNC=12805|UniProtKB=P47989 P47989 XDH PTHR11908:SF80 XANTHINE DEHYDROGENASE XANTHINE DEHYDROGENASE_OXIDASE oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 metabolic process#GO:0008152;purine nucleobase metabolic process#GO:0006144;purine nucleobase catabolic process#GO:0006145;purine-containing compound catabolic process#GO:0072523;nucleobase-containing small molecule metabolic process#GO:0055086;nucleobase metabolic process#GO:0009112;primary metabolic process#GO:0044238;purine-containing compound metabolic process#GO:0072521;cellular process#GO:0009987;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;nucleobase-containing compound metabolic process#GO:0006139;nucleobase catabolic process#GO:0046113 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 Purine metabolism#P02769>Xanthine Oxidase#P03116;Adenine and hypoxanthine salvage pathway#P02723>Xanthine dehydrogenase#P02809 HUMAN|HGNC=2700|UniProtKB=O15075 O15075 DCLK1 PTHR24347:SF401 SERINE/THREONINE-PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE DCLK1 protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740 developmental cell growth#GO:0048588;system development#GO:0048731;anatomical structure development#GO:0048856;plasma membrane bounded cell projection organization#GO:0120036;multicellular organismal process#GO:0032501;axon development#GO:0061564;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;developmental growth#GO:0048589;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;cell development#GO:0048468;cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;cell differentiation#GO:0030154;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;developmental growth involved in morphogenesis#GO:0060560;axonogenesis#GO:0007409;neuron development#GO:0048666;neuron projection extension#GO:1990138;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;axon extension#GO:0048675;cellular process#GO:0009987;neuron projection development#GO:0031175;cell projection morphogenesis#GO:0048858;cell growth#GO:0016049;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;growth#GO:0040007;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=16280|UniProtKB=Q9NQ86 Q9NQ86 TRIM36 PTHR24099:SF18 E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED E3 UBIQUITIN-PROTEIN LIGASE TRIM36 acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;ubiquitin-protein transferase activity#GO:0004842 sexual reproduction#GO:0019953;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;spindle organization#GO:0007051;microtubule cytoskeleton organization#GO:0000226;acrosome reaction#GO:0007340;cellular process#GO:0009987;cell cycle process#GO:0022402;organelle organization#GO:0006996;cell cycle#GO:0007049;cellular component organization#GO:0016043;single fertilization#GO:0007338;cytoskeleton organization#GO:0007010;reproductive process#GO:0022414;fertilization#GO:0009566 acrosomal vesicle#GO:0001669;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular vesicle#GO:0097708;secretory vesicle#GO:0099503;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=8956|UniProtKB=Q15735 Q15735 INPP5J PTHR11200:SF127 INOSITOL 5-PHOSPHATASE PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 5-PHOSPHATASE A catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787 negative regulation of cellular process#GO:0048523;regulation of microtubule polymerization or depolymerization#GO:0031110;biological regulation#GO:0065007;regulation of microtubule cytoskeleton organization#GO:0070507;negative regulation of protein polymerization#GO:0032272;regulation of microtubule-based process#GO:0032886;regulation of microtubule polymerization#GO:0031113;negative regulation of protein-containing complex assembly#GO:0031333;negative regulation of cytoskeleton organization#GO:0051494;regulation of supramolecular fiber organization#GO:1902903;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;negative regulation of biological process#GO:0048519;negative regulation of cellular component organization#GO:0051129;regulation of protein-containing complex assembly#GO:0043254;negative regulation of organelle organization#GO:0010639;regulation of cellular component biogenesis#GO:0044087;regulation of cellular component organization#GO:0051128;regulation of protein polymerization#GO:0032271;negative regulation of supramolecular fiber organization#GO:1902904;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794 cell leading edge#GO:0031252;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cell projection#GO:0042995;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;ruffle#GO:0001726;intracellular anatomical structure#GO:0005622 phosphatase#PC00181;hydrolase#PC00121 HUMAN|HGNC=28497|UniProtKB=Q8N4L1 Q8N4L1 TMEM151A PTHR31893:SF3 TRANSMEMBRANE PROTEIN 151 HOMOLOG TRANSMEMBRANE PROTEIN 151A cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 HUMAN|HGNC=8698|UniProtKB=Q9Y5H2 Q9Y5H2 PCDHGA11 PTHR24028:SF84 CADHERIN-87A PROTOCADHERIN GAMMA-A11 cellular process#GO:0009987;cell adhesion#GO:0007155 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 cell adhesion molecule#PC00069;cadherin#PC00057 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HUMAN|HGNC=16147|UniProtKB=Q9UJA3 Q9UJA3 MCM8 PTHR11630:SF107 DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER DNA HELICASE MCM8 DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA recombination#GO:0006310;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;double-strand break repair#GO:0006302;response to stress#GO:0006950;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;recombinational repair#GO:0000725;cellular response to stress#GO:0033554;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;double-strand break repair via homologous recombination#GO:0000724;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA metabolism protein#PC00009 HUMAN|HGNC=24160|UniProtKB=Q3B7T3 Q3B7T3 BEAN1 PTHR36464:SF1 PROTEIN BEAN1 PROTEIN BEAN1 HUMAN|HGNC=25558|UniProtKB=Q9NVM1 Q9NVM1 EVA1B PTHR48422:SF2 PROTEIN EVA-1 HOMOLOG B-RELATED PROTEIN EVA-1 HOMOLOG B HUMAN|HGNC=5659|UniProtKB=A0A0C4DH38 A0A0C4DH38 IGHV5-51 PTHR23266:SF348 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 5-10-1-RELATED binding#GO:0005488;antigen binding#GO:0003823 adaptive immune response#GO:0002250;response to stimulus#GO:0050896;immune response#GO:0006955;immunoglobulin mediated immune response#GO:0016064;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449;immune effector process#GO:0002252;immune system process#GO:0002376 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=13759|UniProtKB=Q7L576 Q7L576 CYFIP1 PTHR12195:SF4 CYTOPLASMIC FMR1-INTERACTING PROTEIN-RELATED CYTOPLASMIC FMR1-INTERACTING PROTEIN 1 cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;lamellipodium assembly#GO:0030032;cell morphogenesis#GO:0000902;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell development#GO:0048468;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;neuron development#GO:0048666;axonogenesis#GO:0007409;regulation of protein metabolic process#GO:0051246;neuron projection development#GO:0031175;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component assembly#GO:0022607;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cell projection morphogenesis#GO:0048858;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;anatomical structure development#GO:0048856;system development#GO:0048731;axon guidance#GO:0007411;regulation of macromolecule biosynthetic process#GO:0010556;axon development#GO:0061564;regulation of metabolic process#GO:0019222;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;post-transcriptional regulation of gene expression#GO:0010608;plasma membrane bounded cell projection assembly#GO:0120031;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;neuron projection guidance#GO:0097485 cell junction#GO:0030054;intracellular anatomical structure#GO:0005622;synapse#GO:0045202;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;cell projection#GO:0042995;neuron projection#GO:0043005 scaffold/adaptor protein#PC00226 Huntington disease#P00029>p53#P00797 HUMAN|HGNC=27110|UniProtKB=Q8N6D5 Q8N6D5 ANKRD29 PTHR24120:SF3 GH07239P ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 29 HUMAN|HGNC=13201|UniProtKB=Q9H324 Q9H324 ADAMTS10 PTHR13723:SF26 ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 10 metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 external encapsulating structure organization#GO:0045229;protein metabolic process#GO:0019538;extracellular matrix organization#GO:0030198;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;extracellular structure organization#GO:0043062;proteolysis#GO:0006508;metabolic process#GO:0008152;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization#GO:0016043 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 metalloprotease#PC00153 HUMAN|HGNC=28371|UniProtKB=Q8N609 Q8N609 TRAM1L1 PTHR12371:SF9 TRANSLOCATION ASSOCIATED MEMBRANE PROTEIN TRANSLOCATING CHAIN-ASSOCIATED MEMBRANE PROTEIN 1-LIKE 1 localization within membrane#GO:0051668;cellular localization#GO:0051641;localization#GO:0051179;cellular component organization#GO:0016043;endoplasmic reticulum organization#GO:0007029;protein insertion into ER membrane#GO:0045048;protein localization to organelle#GO:0033365;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;establishment of protein localization to membrane#GO:0090150;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein insertion into membrane#GO:0051205;endomembrane system organization#GO:0010256;membrane organization#GO:0061024 membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090 HUMAN|HGNC=29357|UniProtKB=Q9C0F0 Q9C0F0 ASXL3 PTHR13578:SF18 ADDITIONAL SEX COMBS LIKE PROTEIN ASXL POLYCOMB GROUP PROTEIN ASXL3-RELATED protein binding#GO:0005515;chromatin binding#GO:0003682;signaling receptor binding#GO:0005102;binding#GO:0005488 regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;regulation of cellular process#GO:0050794;animal organ morphogenesis#GO:0009887;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;animal gross anatomical part developmental process#GO:0160108;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;positive regulation of transcription by RNA polymerase II#GO:0045944;developmental process#GO:0032502;animal organ development#GO:0048513;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;PcG protein complex#GO:0031519;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=6866|UniProtKB=O95819 O95819 MAP4K4 PTHR48015:SF2 SERINE/THREONINE-PROTEIN KINASE TAO MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 4 protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096 regulation of MAPK cascade#GO:0043408;regulation of response to stimulus#GO:0048583;signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;intracellular signaling cassette#GO:0141124;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;MAPK cascade#GO:0000165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;signaling#GO:0023052;regulation of cell communication#GO:0010646;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Gonadotropin-releasing hormone receptor pathway#P06664>MAP4Ks#P06861;Apoptosis signaling pathway#P00006>GCKR#P00311 HUMAN|HGNC=16094|UniProtKB=Q86UZ6 Q86UZ6 ZBTB46 PTHR24414:SF63 F-BOX/KELCH-REPEAT PROTEIN SKIP4 ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 46 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA-binding transcription repressor activity#GO:0001217;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;binding#GO:0005488;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 non-motor actin binding protein#PC00165;cytoskeletal protein#PC00085 HUMAN|HGNC=1966|UniProtKB=Q04844 Q04844 CHRNE PTHR18945:SF59 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR SUBUNIT EPSILON monoatomic cation transmembrane transporter activity#GO:0008324;postsynaptic neurotransmitter receptor activity#GO:0098960;gated channel activity#GO:0022836;signaling receptor activity#GO:0038023;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;transporter activity#GO:0005215;neurotransmitter receptor activity#GO:0030594;channel activity#GO:0015267;molecular transducer activity#GO:0060089;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation channel activity#GO:0005261;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;ligand-gated monoatomic cation channel activity#GO:0099094;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834 regulation of membrane potential#GO:0042391;calcium ion transport#GO:0006816;response to chemical#GO:0042221;synaptic signaling#GO:0099536;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;cellular response to chemical stimulus#GO:0070887;nervous system process#GO:0050877;response to oxygen-containing compound#GO:1901700;response to stimulus#GO:0050896;signaling#GO:0023052;skeletal muscle contraction#GO:0003009;regulation of biological process#GO:0050789;muscle system process#GO:0003012;establishment of localization#GO:0051234;system process#GO:0003008;transport#GO:0006810;muscle contraction#GO:0006936;cellular response to nitrogen compound#GO:1901699;acetylcholine receptor signaling pathway#GO:0095500;multicellular organismal process#GO:0032501;synaptic transmission, cholinergic#GO:0007271;monoatomic ion transmembrane transport#GO:0034220;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;localization#GO:0051179;cell communication#GO:0007154;response to nitrogen compound#GO:1901698;trans-synaptic signaling#GO:0099537;neuromuscular process#GO:0050905;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;striated muscle contraction#GO:0006941;metal ion transport#GO:0030001;membrane depolarization#GO:0051899;chemical synaptic transmission#GO:0007268;cellular response to stimulus#GO:0051716 membrane#GO:0016020;cell periphery#GO:0071944;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane region#GO:0098590;postsynaptic specialization#GO:0099572;plasma membrane#GO:0005886;synaptic membrane#GO:0097060;signaling receptor complex#GO:0043235;transporter complex#GO:1990351;cell junction#GO:0030054;postsynapse#GO:0098794;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;transmembrane transporter complex#GO:1902495 ligand-gated ion channel#PC00141 Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086 HUMAN|HGNC=26520|UniProtKB=Q8N6L0 Q8N6L0 KASH5 PTHR47300:SF1 PROTEIN KASH5 PROTEIN KASH5 protein-containing complex binding#GO:0044877;binding#GO:0005488 homologous chromosome segregation#GO:0045143;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;chromosome organization involved in meiotic cell cycle#GO:0070192;meiotic cell cycle#GO:0051321;chromosome segregation#GO:0007059;cellular component assembly#GO:0022607;chromosome localization#GO:0050000;homologous chromosome pairing at meiosis#GO:0007129;cytoskeleton organization#GO:0007010;spindle assembly#GO:0051225;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;spindle localization#GO:0051653;nuclear division#GO:0000280;meiosis I#GO:0007127;nuclear chromosome segregation#GO:0098813;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;meiotic cell cycle process#GO:1903046;cell cycle process#GO:0022402;meiotic nuclear division#GO:0140013;spindle organization#GO:0007051;chromosome organization#GO:0051276;meiotic chromosome segregation#GO:0045132;actin filament organization#GO:0007015;organelle fission#GO:0048285;microtubule cytoskeleton organization#GO:0000226;localization#GO:0051179;supramolecular fiber organization#GO:0097435;organelle localization#GO:0051640;meiosis I cell cycle process#GO:0061982;organelle assembly#GO:0070925;actin filament-based process#GO:0030029;sexual reproduction#GO:0019953;actin cytoskeleton organization#GO:0030036;reproductive process#GO:0022414;cell cycle#GO:0007049;telomere localization#GO:0034397 microtubule cytoskeleton#GO:0015630;synaptonemal structure#GO:0099086;chromosome, telomeric region#GO:0000781;nuclear envelope#GO:0005635;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;condensed chromosome#GO:0000793;bounding membrane of organelle#GO:0098588;nuclear membrane#GO:0031965;condensed nuclear chromosome#GO:0000794;synaptonemal complex#GO:0000795;nuclear protein-containing complex#GO:0140513;organelle lumen#GO:0043233;spindle pole#GO:0000922;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;outer membrane#GO:0019867;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;membrane#GO:0016020;nuclear chromosome#GO:0000228;organelle outer membrane#GO:0031968;endomembrane system#GO:0012505;cytoskeleton#GO:0005856;spindle#GO:0005819;organelle membrane#GO:0031090;membraneless organelle#GO:0043228;chromosome#GO:0005694;membrane protein complex#GO:0098796;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=21308|UniProtKB=Q9NYP7 Q9NYP7 ELOVL5 PTHR11157:SF18 FATTY ACID ACYL TRANSFERASE-RELATED VERY LONG CHAIN FATTY ACID ELONGASE 5 transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;fatty acid biosynthetic process#GO:0006633;biosynthetic process#GO:0009058;fatty acid metabolic process#GO:0006631;sphingolipid biosynthetic process#GO:0030148;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;monocarboxylic acid biosynthetic process#GO:0072330;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid biosynthetic process#GO:0046394;small molecule metabolic process#GO:0044281;very long-chain fatty acid metabolic process#GO:0000038;oxoacid metabolic process#GO:0043436 membrane#GO:0016020;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227 acyltransferase#PC00042;transferase#PC00220 HUMAN|HGNC=20151|UniProtKB=Q8NDX2 Q8NDX2 SLC17A8 PTHR11662:SF207 SOLUTE CARRIER FAMILY 17 VESICULAR GLUTAMATE TRANSPORTER 3 carboxylic acid transmembrane transporter activity#GO:0046943;acidic amino acid transmembrane transporter activity#GO:0015172;L-amino acid transmembrane transporter activity#GO:0015179;L-glutamate transmembrane transporter activity#GO:0005313;dicarboxylic acid transmembrane transporter activity#GO:0005310;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;amino acid transmembrane transporter activity#GO:0015171 transport#GO:0006810;synaptic vesicle cycle#GO:0099504;vesicle-mediated transport in synapse#GO:0099003;establishment of localization#GO:0051234;synaptic signaling#GO:0099536;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;biological regulation#GO:0065007;synaptic transmission, glutamatergic#GO:0035249;cell-cell signaling#GO:0007267;neurotransmitter transport#GO:0006836;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;localization#GO:0051179;regulation of synapse structure or activity#GO:0050803;cellular localization#GO:0051641;regulation of biological quality#GO:0065008;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;anterograde trans-synaptic signaling#GO:0098916;signaling#GO:0023052 intracellular membrane-bounded organelle#GO:0043231;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;synaptic vesicle#GO:0008021;synaptic vesicle membrane#GO:0030672;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;endomembrane system#GO:0012505;transport vesicle membrane#GO:0030658;cytoplasmic vesicle membrane#GO:0030659;transport vesicle#GO:0030133;presynapse#GO:0098793;secretory vesicle#GO:0099503;membrane#GO:0016020;vesicle membrane#GO:0012506;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;cell junction#GO:0030054 secondary carrier transporter#PC00258 Ionotropic glutamate receptor pathway#P00037>Vglut#P01021 HUMAN|HGNC=7729|UniProtKB=Q15019 Q15019 SEPTIN2 PTHR18884:SF67 SEPTIN SEPTIN-2 ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818 cilium organization#GO:0044782;localization#GO:0051179;cytoskeleton-dependent cytokinesis#GO:0061640;cytokinesis#GO:0000910;organelle assembly#GO:0070925;cell projection organization#GO:0030030;cell division#GO:0051301;cell cycle process#GO:0022402;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cell cycle#GO:0007049;intracellular protein localization#GO:0008104;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection assembly#GO:0120031;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cellular process#GO:0009987;cell projection assembly#GO:0030031;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;macromolecule localization#GO:0033036 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;cell division site#GO:0032153;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;cell periphery#GO:0071944;cell cortex#GO:0005938;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 cytoskeletal protein#PC00085 Parkinson disease#P00049>CDCrel-1#P01226 HUMAN|HGNC=10807|UniProtKB=Q92629 Q92629 SGCD PTHR12939:SF6 SARCOGLYCAN DELTA-SARCOGLYCAN animal gross anatomical part developmental process#GO:0160108;circulatory system process#GO:0003013;muscle tissue development#GO:0060537;system development#GO:0048731;anatomical structure development#GO:0048856;heart process#GO:0003015;circulatory system development#GO:0072359;developmental process#GO:0032502;striated muscle tissue development#GO:0014706;heart contraction#GO:0060047;system process#GO:0003008;multicellular organism development#GO:0007275;cardiac muscle tissue development#GO:0048738;animal organ development#GO:0048513;blood circulation#GO:0008015;heart development#GO:0007507;multicellular organismal process#GO:0032501;tissue development#GO:0009888 sarcolemma#GO:0042383;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane protein complex#GO:0098796;membrane#GO:0016020;dystrophin-associated glycoprotein complex#GO:0016010;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944 cytoskeletal protein#PC00085 HUMAN|HGNC=2972|UniProtKB=Q05193 Q05193 DNM1 PTHR11566:SF32 DYNAMIN DYNAMIN-1 protein binding#GO:0005515;hydrolase activity#GO:0016787;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;microtubule binding#GO:0008017;GTPase activity#GO:0003924;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;tubulin binding#GO:0015631;hydrolase activity, acting on acid anhydrides#GO:0016817;cytoskeletal protein binding#GO:0008092 synaptic vesicle recycling#GO:0036465;synaptic vesicle localization#GO:0097479;vesicle-mediated transport#GO:0016192;membrane organization#GO:0061024;establishment of vesicle localization#GO:0051650;synaptic vesicle transport#GO:0048489;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle localization#GO:0051648;vesicle-mediated transport in synapse#GO:0099003;establishment of localization#GO:0051234;import into cell#GO:0098657;cellular component organization or biogenesis#GO:0071840;vesicle organization#GO:0016050;vesicle budding from membrane#GO:0006900;synaptic vesicle cycle#GO:0099504;transport#GO:0006810;endocytosis#GO:0006897;establishment of organelle localization#GO:0051656;cellular component organization#GO:0016043;synaptic vesicle endocytosis#GO:0048488;cellular localization#GO:0051641;localization#GO:0051179;organelle localization#GO:0051640 membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cell junction#GO:0030054;cytoskeleton#GO:0005856;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;membrane#GO:0016020;microtubule cytoskeleton#GO:0015630;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226 membrane traffic protein#PC00150 Gonadotropin-releasing hormone receptor pathway#P06664>Dnm1#P06781;CCKR signaling map#P06959>Dynamin#P07100 HUMAN|HGNC=26044|UniProtKB=Q9NWZ8 Q9NWZ8 GEMIN8 PTHR16238:SF7 GEM-ASSOCIATED PROTEIN 8 GEM-ASSOCIATED PROTEIN 8 RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;protein-containing complex organization#GO:0043933;protein-RNA complex organization#GO:0071826;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;mRNA processing#GO:0006397;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular component assembly#GO:0022607;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;protein-RNA complex assembly#GO:0022618;mRNA splicing, via spliceosome#GO:0000398;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;spliceosomal snRNP assembly#GO:0000387 SMN complex#GO:0032797;SMN-Sm protein complex#GO:0034719;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;Sm-like protein family complex#GO:0120114;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 HUMAN|HGNC=2579|UniProtKB=P08574 P08574 CYC1 PTHR10266:SF3 CYTOCHROME C1 CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL electron transfer activity#GO:0009055;monoatomic cation transmembrane transporter activity#GO:0008324;oxidoreductase activity#GO:0016491;monoatomic ion transmembrane transporter activity#GO:0015075;active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399;catalytic activity#GO:0003824;proton transmembrane transporter activity#GO:0015078;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;oxidoreductase activity, acting on diphenols and related substances as donors#GO:0016679 mitochondrial electron transport, ubiquinol to cytochrome c#GO:0006122;mitochondrial ATP synthesis coupled electron transport#GO:0042775;respiratory electron transport chain#GO:0022904;cellular process#GO:0009987;electron transport chain#GO:0022900;aerobic respiration#GO:0009060;oxidative phosphorylation#GO:0006119;ATP synthesis coupled electron transport#GO:0042773;energy derivation by oxidation of organic compounds#GO:0015980;cellular respiration#GO:0045333;generation of precursor metabolites and energy#GO:0006091;metabolic process#GO:0008152;aerobic electron transport chain#GO:0019646 mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 Huntington disease#P00029>Cytochrome c#P00785;FAS signaling pathway#P00020>CytochromeC#P00620;ATP synthesis#P02721>Cyt bc1#P02799 HUMAN|HGNC=17142|UniProtKB=Q96CV9 Q96CV9 OPTN PTHR31553:SF2 NF-KAPPA-B ESSENTIAL MODULATOR OPTINEURIN protein binding#GO:0005515;modification-dependent protein binding#GO:0140030;polyubiquitin modification-dependent protein binding#GO:0031593;binding#GO:0005488;K63-linked polyubiquitin modification-dependent protein binding#GO:0070530 localization#GO:0051179;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;protein localization to organelle#GO:0033365;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;cellular component organization#GO:0016043;Golgi organization#GO:0007030;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;intracellular protein localization#GO:0008104;protein localization to Golgi apparatus#GO:0034067;regulation of response to stimulus#GO:0048583;regulation of signal transduction#GO:0009966;endomembrane system organization#GO:0010256;biological regulation#GO:0065007;macromolecule localization#GO:0033036;organelle organization#GO:0006996;cellular process#GO:0009987;regulation of canonical NF-kappaB signal transduction#GO:0043122 nucleus#GO:0005634;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 Huntington disease#P00029>FIP-2#P00772 HUMAN|HGNC=28785|UniProtKB=Q7Z6M4 Q7Z6M4 MTERF4 PTHR13068:SF203 CGI-12 PROTEIN-RELATED TRANSCRIPTION TERMINATION FACTOR 4, MITOCHONDRIAL regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;organelle assembly#GO:0070925;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;negative regulation of cellular process#GO:0048523;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;mitochondrial ribosome assembly#GO:0061668;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;regulation of biological process#GO:0050789;negative regulation of metabolic process#GO:0009892;ribonucleoprotein complex biogenesis#GO:0022613;ribosome assembly#GO:0042255;ribosome biogenesis#GO:0042254;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cellular component assembly#GO:0022607;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;cellular component organization or biogenesis#GO:0071840 mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=414|UniProtKB=P04075 P04075 ALDOA PTHR11627:SF1 FRUCTOSE-BISPHOSPHATE ALDOLASE FRUCTOSE-BISPHOSPHATE ALDOLASE A carbon-carbon lyase activity#GO:0016830;catalytic activity#GO:0003824;aldehyde-lyase activity#GO:0016832;fructose-bisphosphate aldolase activity#GO:0004332;lyase activity#GO:0016829 cellular respiration#GO:0045333;organophosphate catabolic process#GO:0046434;ribonucleoside diphosphate catabolic process#GO:0009191;purine ribonucleoside diphosphate catabolic process#GO:0009181;aerobic respiration#GO:0009060;nucleoside diphosphate metabolic process#GO:0009132;purine nucleotide catabolic process#GO:0006195;pyridine-containing compound metabolic process#GO:0072524;nucleoside phosphate catabolic process#GO:1901292;catabolic process#GO:0009056;nucleoside phosphate metabolic process#GO:0006753;carbohydrate derivative catabolic process#GO:1901136;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate metabolic process#GO:0005975;primary metabolic process#GO:0044238;purine nucleoside triphosphate metabolic process#GO:0009144;nucleoside diphosphate catabolic process#GO:0009134;purine ribonucleotide catabolic process#GO:0009154;energy derivation by oxidation of organic compounds#GO:0015980;ADP metabolic process#GO:0046031;nucleotide catabolic process#GO:0009166;purine ribonucleoside diphosphate metabolic process#GO:0009179;generation of precursor metabolites and energy#GO:0006091;nucleobase-containing compound metabolic process#GO:0006139;nucleobase-containing compound catabolic process#GO:0034655;organophosphate metabolic process#GO:0019637;purine ribonucleoside triphosphate metabolic process#GO:0009205;glycolytic process#GO:0006096;ribonucleotide catabolic process#GO:0009261;carbohydrate derivative metabolic process#GO:1901135;carbohydrate catabolic process#GO:0016052;nucleotide metabolic process#GO:0009117;ribonucleotide metabolic process#GO:0009259;purine nucleoside diphosphate metabolic process#GO:0009135;oxoacid metabolic process#GO:0043436;small molecule metabolic process#GO:0044281;pyruvate metabolic process#GO:0006090;pyridine nucleotide catabolic process#GO:0019364;phosphorus metabolic process#GO:0006793;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;ribonucleoside diphosphate metabolic process#GO:0009185;pyridine-containing compound catabolic process#GO:0072526;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;purine-containing compound catabolic process#GO:0072523;purine nucleoside diphosphate catabolic process#GO:0009137;nucleobase-containing small molecule metabolic process#GO:0055086;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;ADP catabolic process#GO:0046032;ribose phosphate metabolic process#GO:0019693;ATP metabolic process#GO:0046034;cellular process#GO:0009987;nicotinamide nucleotide metabolic process#GO:0046496 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 aldolase#PC00044;lyase#PC00144 Fructose galactose metabolism#P02744>Fructose bisphosphate aldolase#P02959;Glycolysis#P00024>Aldolase#P00679 HUMAN|HGNC=17893|UniProtKB=Q9UHJ9 Q9UHJ9 PGAP2 PTHR12892:SF11 FGF RECEPTOR ACTIVATING PROTEIN 1 ACYLTRANSFERASE PGAP2 phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;GPI anchored protein biosynthesis#GO:0180046;glycerolipid metabolic process#GO:0046486;liposaccharide metabolic process#GO:1903509;glycolipid metabolic process#GO:0006664;phospholipid biosynthetic process#GO:0008654;phospholipid metabolic process#GO:0006644;glycolipid biosynthetic process#GO:0009247;protein metabolic process#GO:0019538;organophosphate biosynthetic process#GO:0090407;organophosphate metabolic process#GO:0019637;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;glycerolipid biosynthetic process#GO:0045017;GPI anchor biosynthetic process#GO:0006506;glycerophospholipid metabolic process#GO:0006650;gene expression#GO:0010467;protein maturation#GO:0051604;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058;metabolic process#GO:0008152;glycerophospholipid biosynthetic process#GO:0046474;GPI anchor metabolic process#GO:0006505;lipid metabolic process#GO:0006629;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229 protein modifying enzyme#PC00260 HUMAN|HGNC=28294|UniProtKB=Q8IYU4 Q8IYU4 UBQLNL PTHR10677:SF9 UBIQUILIN UBIQUILIN-LIKE PROTEIN protein binding#GO:0005515;binding#GO:0005488;polyubiquitin modification-dependent protein binding#GO:0031593;modification-dependent protein binding#GO:0140030 metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;catabolic process#GO:0009056 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 scaffold/adaptor protein#PC00226 HUMAN|HGNC=4598|UniProtKB=O15303 O15303 GRM6 PTHR24060:SF24 METABOTROPIC GLUTAMATE RECEPTOR METABOTROPIC GLUTAMATE RECEPTOR 6 G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;adenylate cyclase inhibiting G protein-coupled glutamate receptor activity#GO:0001640;glutamate receptor activity#GO:0008066;transmembrane signaling receptor activity#GO:0004888 cellular process#GO:0009987;signal transduction#GO:0007165;biological regulation#GO:0065007;regulation of trans-synaptic signaling#GO:0099177;cell surface receptor signaling pathway#GO:0007166;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cell communication#GO:0010646;modulation of chemical synaptic transmission#GO:0050804;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of signaling#GO:0023051;G protein-coupled receptor signaling pathway#GO:0007186;glutamate receptor signaling pathway#GO:0007215;regulation of synaptic transmission, glutamatergic#GO:0051966;cell communication#GO:0007154 G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GqPCR#P00730;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GoPCR#P00725;Metabotropic glutamate receptor group III pathway#P00039>mGluR4/6/7/8#P01044 HUMAN|HGNC=3168|UniProtKB=Q9HBW0 Q9HBW0 LPAR2 PTHR22750:SF38 G-PROTEIN COUPLED RECEPTOR LYSOPHOSPHATIDIC ACID RECEPTOR 2 G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021 HUMAN|HGNC=27102|UniProtKB=Q86Y91 Q86Y91 KIF18B PTHR24115:SF414 KINESIN-RELATED KINESIN-LIKE PROTEIN KIF18B cytoskeletal protein binding#GO:0008092;hydrolase activity, acting on acid anhydrides#GO:0016817;cytoskeletal motor activity#GO:0003774;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;ATP-dependent activity#GO:0140657;protein binding#GO:0005515;plus-end-directed microtubule motor activity#GO:0008574;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;tubulin binding#GO:0015631;macromolecular conformation isomerase activity#GO:0120543;ribonucleoside triphosphate phosphatase activity#GO:0017111;isomerase activity#GO:0016853;polypeptide conformation or assembly isomerase activity#GO:0120544;microtubule binding#GO:0008017;hydrolase activity#GO:0016787;microtubule motor activity#GO:0003777;ATP hydrolysis activity#GO:0016887 protein depolymerization#GO:0051261;chromosome localization#GO:0050000;cytoskeleton organization#GO:0007010;microtubule depolymerization#GO:0007019;cellular process#GO:0009987;microtubule polymerization or depolymerization#GO:0031109;mitotic sister chromatid segregation#GO:0000070;organelle organization#GO:0006996;microtubule-based process#GO:0007017;protein-containing complex organization#GO:0043933;chromosome organization#GO:0051276;mitotic cell cycle process#GO:1903047;cellular component organization or biogenesis#GO:0071840;chromosome segregation#GO:0007059;protein-containing complex disassembly#GO:0032984;microtubule-based movement#GO:0007018;mitotic cell cycle#GO:0000278;mitotic nuclear division#GO:0140014;cell cycle process#GO:0022402;cellular component organization#GO:0016043;nuclear chromosome segregation#GO:0098813;sister chromatid segregation#GO:0000819;cell cycle#GO:0007049;supramolecular fiber organization#GO:0097435;cellular component disassembly#GO:0022411;organelle fission#GO:0048285;microtubule cytoskeleton organization#GO:0000226;localization#GO:0051179;organelle localization#GO:0051640;nuclear division#GO:0000280 cytoplasmic microtubule#GO:0005881;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;mitotic spindle#GO:0072686;intracellular organelle#GO:0043229;spindle microtubule#GO:0005876;microtubule#GO:0005874;spindle midzone#GO:0051233;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membrane-bounded organelle#GO:0043227;microtubule cytoskeleton#GO:0015630;nucleus#GO:0005634;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;spindle#GO:0005819;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=4074|UniProtKB=Q06547 Q06547 GABPB1 PTHR24193:SF76 ANKYRIN REPEAT PROTEIN GA-BINDING PROTEIN SUBUNIT BETA-1 transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA metabolic process#GO:0051252;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of DNA-templated transcription#GO:0006355;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=20743|UniProtKB=Q96KN4 Q96KN4 LRATD1 PTHR46341:SF1 PROTEIN FAM84B-RELATED PROTEIN LRATD1 cellular process#GO:0009987;developmental process#GO:0032502;anatomical structure morphogenesis#GO:0009653;cell motility#GO:0048870;anatomical structure development#GO:0048856;cell morphogenesis#GO:0000902 HUMAN|HGNC=23225|UniProtKB=Q8N0X2 Q8N0X2 SPAG16 PTHR14604:SF8 WD40 REPEAT PF20 SPERM-ASSOCIATED ANTIGEN 16 PROTEIN plasma membrane bounded cell projection assembly#GO:0120031;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection organization#GO:0120036;organelle assembly#GO:0070925;microtubule bundle formation#GO:0001578;microtubule cytoskeleton organization#GO:0000226;axoneme assembly#GO:0035082;cilium organization#GO:0044782;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cell projection organization#GO:0030030 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;axoneme#GO:0005930;intracellular organelle#GO:0043229;cilium#GO:0005929;cytoskeleton#GO:0005856;axonemal central apparatus#GO:1990716;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;ciliary plasm#GO:0097014;cellular anatomical structure#GO:0110165;organelle#GO:0043226 microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=13917|UniProtKB=Q13838 Q13838 DDX39B PTHR47958:SF124 ATP-DEPENDENT RNA HELICASE DBP3 SPLICEOSOME RNA HELICASE DDX39B macromolecular conformation isomerase activity#GO:0120543;RNA helicase activity#GO:0003724;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;isomerase activity#GO:0016853;catalytic activity, acting on RNA#GO:0140098;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;mRNA processing#GO:0006397;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;gene expression#GO:0010467;RNA processing#GO:0006396;nucleic acid biosynthetic process#GO:0141187;mRNA export from nucleus#GO:0006406;RNA metabolic process#GO:0016070;cellular localization#GO:0051641;mRNA splicing, via spliceosome#GO:0000398;mRNA metabolic process#GO:0016071;RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907;transport#GO:0006810;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;nitrogen compound transport#GO:0071705;macromolecule localization#GO:0033036;macromolecule biosynthetic process#GO:0009059;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA splicing, via transesterification reactions#GO:0000375;nucleocytoplasmic transport#GO:0006913;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;nucleic acid transport#GO:0050657;localization#GO:0051179;nuclear export#GO:0051168;nuclear transport#GO:0051169;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA localization#GO:0006403;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;mRNA transport#GO:0051028;establishment of RNA localization#GO:0051236;RNA biosynthetic process#GO:0032774 RNA helicase#PC00032 HUMAN|HGNC=2768|UniProtKB=P35659 P35659 DEK PTHR13468:SF24 DEK PROTEIN PROTEIN DEK binding#GO:0005488;histone binding#GO:0042393;protein binding#GO:0005515 regulation of double-strand break repair#GO:2000779;regulation of cellular response to stress#GO:0080135;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;chromatin remodeling#GO:0006338;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of DNA metabolic process#GO:0051052;cellular component organization#GO:0016043;regulation of gene expression#GO:0010468;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;regulation of DNA repair#GO:0006282;regulation of response to stimulus#GO:0048583;regulation of response to stress#GO:0080134;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;ATPase complex#GO:1904949;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;chromosome#GO:0005694;organelle lumen#GO:0043233;SWI/SNF superfamily-type complex#GO:0070603;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;chromatin#GO:0000785;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=797|UniProtKB=Q92858 Q92858 ATOH1 PTHR19290:SF82 BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED TRANSCRIPTION FACTOR ATOH1 nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 positive regulation of biological process#GO:0048518;cellular process#GO:0009987;neuron projection development#GO:0031175;nervous system development#GO:0007399;positive regulation of macromolecule metabolic process#GO:0010604;neuron differentiation#GO:0030182;positive regulation of transcription by RNA polymerase II#GO:0045944;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;animal organ development#GO:0048513;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;cell development#GO:0048468;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;cell projection organization#GO:0030030;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;neuron development#GO:0048666;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;axon development#GO:0061564;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;plasma membrane bounded cell projection organization#GO:0120036;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;multicellular organismal process#GO:0032501;developmental process#GO:0032502;sensory organ development#GO:0007423;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=49394|UniProtKB=H3BNL8 H3BNL8 ARMH2 PTHR37679:SF1 ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 2 ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 2 HUMAN|HGNC=7553|UniProtKB=P01106 P01106 MYC PTHR45851:SF1 MYC PROTO-ONCOGENE MYC PROTO-ONCOGENE PROTEIN transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;positive regulation of cell population proliferation#GO:0008284;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of cell population proliferation#GO:0042127;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 intracellular anatomical structure#GO:0005622;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 CCKR signaling map#P06959>MYC#G06979;Wnt signaling pathway#P00057>Wnt Target Genes#G01558;PDGF signaling pathway#P00047>c-Myc#P01172;Oxidative stress response#P00046>Myc#P01124;p53 pathway feedback loops 2#P04398>Myc#P04649;CCKR signaling map#P06959>MYC#G07272;Interleukin signaling pathway#P00036>c-Myc#P00995 HUMAN|HGNC=25128|UniProtKB=Q96HP4 Q96HP4 OXNAD1 PTHR46505:SF1 OXIDOREDUCTASE NAD-BINDING DOMAIN-CONTAINING PROTEIN 1 OXIDOREDUCTASE NAD-BINDING DOMAIN-CONTAINING PROTEIN 1 oxidoreductase#PC00176 HUMAN|HGNC=43430|UniProtKB=A0A096LP01 A0A096LP01 SMIM26 PTHR40386:SF1 SMALL INTEGRAL MEMBRANE PROTEIN 26 SMALL INTEGRAL MEMBRANE PROTEIN 26 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=28528|UniProtKB=Q6UWM9 Q6UWM9 UGT2A3 PTHR48043:SF137 EG:EG0003.4 PROTEIN-RELATED UDP-GLUCURONOSYLTRANSFERASE 2A3 hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;glucuronosyltransferase activity#GO:0015020;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194 HUMAN|HGNC=8654|UniProtKB=P05166 P05166 PCCB PTHR43842:SF2 PROPIONYL-COA CARBOXYLASE BETA CHAIN PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL ligase activity#GO:0016874;catalytic activity#GO:0003824 mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;ligase#PC00142 Succinate to proprionate conversion#P02777>Methylmalonyl-CoA decarboxylase#P03163;Methylmalonyl pathway#P02755>Propionyl-CoA carboxylase#P03033 HUMAN|HGNC=11272|UniProtKB=P02549 P02549 SPTA1 PTHR11915:SF431 SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN SPECTRIN ALPHA CHAIN, ERYTHROCYTIC 1 actin filament binding#GO:0051015;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;binding#GO:0005488;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 cellular component organization or biogenesis#GO:0071840;actin cytoskeleton organization#GO:0030036;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component organization#GO:0016043;actin filament-based process#GO:0030029;cellular process#GO:0009987 cortical cytoskeleton#GO:0030863;actin cytoskeleton#GO:0015629;cell cortex#GO:0005938;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cell projection#GO:0042995;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;cell periphery#GO:0071944;cortical actin cytoskeleton#GO:0030864;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;cell junction#GO:0030054 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=30575|UniProtKB=Q6IA17 Q6IA17 SIGIRR PTHR11890:SF19 INTERLEUKIN-1 RECEPTOR FAMILY MEMBER SINGLE IG IL-1-RELATED RECEPTOR cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 membrane#GO:0016020;cell periphery#GO:0071944;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=6901|UniProtKB=P48740 P48740 MASP1 PTHR24255:SF13 COMPLEMENT COMPONENT 1, S SUBCOMPONENT-RELATED MANNAN-BINDING LECTIN SERINE PROTEASE 1 serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;serine-type peptidase activity#GO:0008236 immune system process#GO:0002376;regulation of immune response#GO:0050776;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of immune system process#GO:0002682;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;humoral immune response#GO:0006959;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;immune effector process#GO:0002252;innate immune response#GO:0045087;response to external stimulus#GO:0009605;defense response#GO:0006952;response to biotic stimulus#GO:0009607;positive regulation of immune system process#GO:0002684;response to stress#GO:0006950;positive regulation of biological process#GO:0048518;defense response to symbiont#GO:0140546;activation of immune response#GO:0002253;immune response#GO:0006955;complement activation#GO:0006956;positive regulation of response to stimulus#GO:0048584;defense response to other organism#GO:0098542;biological regulation#GO:0065007;response to other organism#GO:0051707 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 serine protease#PC00203 HUMAN|HGNC=19222|UniProtKB=Q9NYS7 Q9NYS7 WSB2 PTHR15622:SF1 WD40 REPEAT PROTEIN WD REPEAT AND SOCS BOX-CONTAINING PROTEIN 2 metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;primary metabolic process#GO:0044238;protein modification process#GO:0036211;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567 HUMAN|HGNC=25919|UniProtKB=Q969W8 Q969W8 ZNF566 PTHR24381:SF483 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 566 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=25915|UniProtKB=Q5U5X8 Q5U5X8 FAM222A PTHR16070:SF2 PROTEIN FAM222A-RELATED PROTEIN FAM222A HUMAN|HGNC=9353|UniProtKB=P32119 P32119 PRDX2 PTHR10681:SF161 THIOREDOXIN PEROXIDASE PEROXIREDOXIN-2 antioxidant activity#GO:0016209;peroxidase activity#GO:0004601;catalytic activity#GO:0003824;oxidoreductase activity, acting on peroxide as acceptor#GO:0016684;oxidoreductase activity#GO:0016491 cell redox homeostasis#GO:0045454;response to reactive oxygen species#GO:0000302;cellular homeostasis#GO:0019725;cellular response to chemical stress#GO:0062197;response to oxidative stress#GO:0006979;superoxide metabolic process#GO:0006801;metabolic process#GO:0008152;reactive oxygen species metabolic process#GO:0072593;detoxification#GO:0098754;cellular response to toxic substance#GO:0097237;response to chemical#GO:0042221;cellular response to oxidative stress#GO:0034599;cellular response to oxygen-containing compound#GO:1901701;cellular oxidant detoxification#GO:0098869;cellular process#GO:0009987;response to stress#GO:0006950;cellular response to stress#GO:0033554;response to oxygen-containing compound#GO:1901700;cellular detoxification#GO:1990748;cellular response to chemical stimulus#GO:0070887;homeostatic process#GO:0042592;hydrogen peroxide metabolic process#GO:0042743;catabolic process#GO:0009056;response to stimulus#GO:0050896;response to toxic substance#GO:0009636;cellular response to stimulus#GO:0051716 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 oxidoreductase#PC00176;peroxidase#PC00180 HUMAN|HGNC=15528|UniProtKB=Q99675 Q99675 CGRRF1 PTHR15379:SF2 CELL GROWTH REGULATOR WITH RING FINGER DOMAIN PROTEIN 1 CELL GROWTH REGULATOR WITH RING FINGER DOMAIN PROTEIN 1 negative regulation of cellular process#GO:0048523;negative regulation of cell growth#GO:0030308;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of cell growth#GO:0001558;regulation of growth#GO:0040008;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519 HUMAN|HGNC=23789|UniProtKB=Q9BW66 Q9BW66 CINP PTHR15827:SF2 CYCLIN-DEPENDENT KINASE 2-INTERACTING PROTEIN CYCLIN-DEPENDENT KINASE 2-INTERACTING PROTEIN nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular process#GO:0009987;DNA replication#GO:0006260;nucleobase-containing compound metabolic process#GO:0006139;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 Cell cycle#P00013>Cdk2#P00485 HUMAN|HGNC=24024|UniProtKB=O60774 O60774 FMO6P PTHR23023:SF81 DIMETHYLANILINE MONOOXYGENASE DIMETHYLANILINE MONOOXYGENASE [N-OXIDE-FORMING] 6-RELATED oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen#GO:0016709;catalytic activity#GO:0003824;monooxygenase activity#GO:0004497;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705 sulfur compound metabolic process#GO:0006790;metabolic process#GO:0008152;cellular process#GO:0009987;biosynthetic process#GO:0009058 oxidoreductase#PC00176;oxygenase#PC00177 HUMAN|HGNC=17973|UniProtKB=Q9P109 Q9P109 GCNT4 PTHR19297:SF7 GLYCOSYLTRANSFERASE 14 FAMILY MEMBER BETA-1,3-GALACTOSYL-O-GLYCOSYL-GLYCOPROTEIN BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE 4 acetylglucosaminyltransferase activity#GO:0008375;glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194;hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;catalytic activity#GO:0003824 glycosyltransferase#PC00111 HUMAN|HGNC=24311|UniProtKB=Q6XD76 Q6XD76 ASCL4 PTHR13935:SF51 ACHAETE-SCUTE TRANSCRIPTION FACTOR-RELATED ACHAETE-SCUTE HOMOLOG 4 double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264;basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=7419|UniProtKB=P00395 P00395 MT-CO1 PTHR10422:SF18 CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 1 electron transfer activity#GO:0009055;monoatomic cation transmembrane transporter activity#GO:0008324;catalytic activity#GO:0003824;proton transmembrane transporter activity#GO:0015078;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic ion transmembrane transporter activity#GO:0015075;oxidoreductase activity#GO:0016491;primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804 energy derivation by oxidation of organic compounds#GO:0015980;cellular respiration#GO:0045333;aerobic respiration#GO:0009060;metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091;electron transport chain#GO:0022900;respiratory electron transport chain#GO:0022904;cellular process#GO:0009987 transmembrane transporter complex#GO:1902495;respiratory chain complex IV#GO:0045277;transporter complex#GO:1990351;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytochrome complex#GO:0070069;respiratory chain complex#GO:0098803;membrane protein complex#GO:0098796;membrane#GO:0016020;oxidoreductase complex#GO:1990204 oxidoreductase#PC00176;oxidase#PC00175 ATP synthesis#P02721>Cytochrome oxidase aa3#P02793 HUMAN|HGNC=24975|UniProtKB=Q15270 Q15270 NKX1-1 PTHR24340:SF26 HOMEOBOX PROTEIN NKX NK1 TRANSCRIPTION FACTOR-RELATED PROTEIN 1 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 developmental process#GO:0032502;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=6291|UniProtKB=Q9H2S1 Q9H2S1 KCNN2 PTHR10153:SF43 SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL PROTEIN 2 gated channel activity#GO:0022836;binding#GO:0005488;monoatomic cation transmembrane transporter activity#GO:0008324;protein binding#GO:0005515;transporter activity#GO:0005215;calmodulin binding#GO:0005516;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;potassium channel activity#GO:0005267;ligand-gated monoatomic ion channel activity#GO:0015276;calcium-activated cation channel activity#GO:0005227;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;monoatomic ion-gated channel activity#GO:0022839;ligand-gated channel activity#GO:0022834;calcium-activated potassium channel activity#GO:0015269;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261 establishment of localization#GO:0051234;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;transport#GO:0006810;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;cellular process#GO:0009987 cell junction#GO:0030054;neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;dendritic tree#GO:0097447;dendrite#GO:0030425;cell body#GO:0044297;dendritic spine#GO:0043197;postsynapse#GO:0098794;neuronal cell body#GO:0043025;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;neuron spine#GO:0044309;cellular anatomical structure#GO:0110165;synapse#GO:0045202 ion channel#PC00133;voltage-gated ion channel#PC00241 HUMAN|HGNC=3353|UniProtKB=P09104 P09104 ENO2 PTHR11902:SF10 ENOLASE GAMMA-ENOLASE phosphopyruvate hydratase activity#GO:0004634;catalytic activity#GO:0003824;lyase activity#GO:0016829;carbon-oxygen lyase activity#GO:0016835;hydro-lyase activity#GO:0016836 carbohydrate catabolic process#GO:0016052;nucleotide metabolic process#GO:0009117;ribonucleotide metabolic process#GO:0009259;purine nucleoside diphosphate metabolic process#GO:0009135;oxoacid metabolic process#GO:0043436;pyruvate metabolic process#GO:0006090;pyridine nucleotide catabolic process#GO:0019364;small molecule metabolic process#GO:0044281;pyridine-containing compound catabolic process#GO:0072526;ribonucleoside diphosphate metabolic process#GO:0009185;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;carboxylic acid metabolic process#GO:0019752;phosphorus metabolic process#GO:0006793;monocarboxylic acid metabolic process#GO:0032787;purine nucleoside diphosphate catabolic process#GO:0009137;nucleobase-containing small molecule metabolic process#GO:0055086;purine-containing compound catabolic process#GO:0072523;ADP catabolic process#GO:0046032;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;nicotinamide nucleotide metabolic process#GO:0046496;aerobic respiration#GO:0009060;purine ribonucleoside diphosphate catabolic process#GO:0009181;cellular respiration#GO:0045333;organophosphate catabolic process#GO:0046434;ribonucleoside diphosphate catabolic process#GO:0009191;pyridine-containing compound metabolic process#GO:0072524;purine nucleotide catabolic process#GO:0006195;nucleoside diphosphate metabolic process#GO:0009132;nucleoside phosphate metabolic process#GO:0006753;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate derivative catabolic process#GO:1901136;carbohydrate metabolic process#GO:0005975;nucleoside phosphate catabolic process#GO:1901292;catabolic process#GO:0009056;nucleoside diphosphate catabolic process#GO:0009134;purine nucleoside triphosphate metabolic process#GO:0009144;purine ribonucleotide catabolic process#GO:0009154;primary metabolic process#GO:0044238;energy derivation by oxidation of organic compounds#GO:0015980;ADP metabolic process#GO:0046031;purine ribonucleoside diphosphate metabolic process#GO:0009179;generation of precursor metabolites and energy#GO:0006091;nucleotide catabolic process#GO:0009166;nucleobase-containing compound metabolic process#GO:0006139;purine ribonucleoside triphosphate metabolic process#GO:0009205;glycolytic process#GO:0006096;ribonucleotide catabolic process#GO:0009261;carbohydrate derivative metabolic process#GO:1901135;nucleobase-containing compound catabolic process#GO:0034655;organophosphate metabolic process#GO:0019637 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829;catalytic complex#GO:1902494 metabolite interconversion enzyme#PC00262;lyase#PC00144 Glycolysis#P00024>Enolase#P00678 HUMAN|HGNC=2239|UniProtKB=Q9UNS2 Q9UNS2 COPS3 PTHR10758:SF1 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3 COP9 SIGNALOSOME COMPLEX SUBUNIT 3 modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238;catabolic process#GO:0009056;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;COP9 signalosome#GO:0008180;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 protein modifying enzyme#PC00260;protease#PC00190 HUMAN|HGNC=26347|UniProtKB=B5ME19 B5ME19 EIF3CL PTHR13937:SF0 EUKARYOTIC TRANSLATION INITIATION FACTOR 3, SUBUNIT 8 EIF3S8 -RELATED EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT C-RELATED translation factor activity#GO:0180051;translation initiation factor activity#GO:0003743 metabolic process#GO:0008152;translation#GO:0006412;translational initiation#GO:0006413;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;biosynthetic process#GO:0009058 eukaryotic translation initiation factor 3 complex#GO:0005852;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 translational protein#PC00263;translation initiation factor#PC00224;translation factor#PC00223 HUMAN|HGNC=14920|UniProtKB=Q9NYV8 Q9NYV8 TAS2R14 PTHR11394:SF23 TASTE RECEPTOR TYPE 2 TASTE RECEPTOR TYPE 2 MEMBER 14 transmembrane signaling receptor activity#GO:0004888;taste receptor activity#GO:0008527;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;bitter taste receptor activity#GO:0033038 detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;sensory perception of bitter taste#GO:0050913;detection of chemical stimulus#GO:0009593;response to chemical#GO:0042221;response to stimulus#GO:0050896;multicellular organismal process#GO:0032501;sensory perception of taste#GO:0050909;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;sensory perception#GO:0007600;nervous system process#GO:0050877;detection of chemical stimulus involved in sensory perception of taste#GO:0050912;detection of chemical stimulus involved in sensory perception of bitter taste#GO:0001580;system process#GO:0003008 cellular anatomical structure#GO:0110165;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=28361|UniProtKB=Q9BW62 Q9BW62 KATNAL1 PTHR23074:SF65 AAA DOMAIN-CONTAINING KATANIN P60 ATPASE-CONTAINING SUBUNIT A-LIKE 1 polypeptide conformation or assembly isomerase activity#GO:0120544;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP-dependent activity#GO:0140657;hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817;macromolecular conformation isomerase activity#GO:0120543;catalytic activity, acting on a protein#GO:0140096;isomerase activity#GO:0016853;ribonucleoside triphosphate phosphatase activity#GO:0017111 cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;cytoskeleton organization#GO:0007010;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226 spindle#GO:0005819;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;microtubule cytoskeleton#GO:0015630;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737 non-motor microtubule binding protein#PC00166;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=13838|UniProtKB=Q86SQ6 Q86SQ6 ADGRA1 PTHR45930:SF3 G-PROTEIN COUPLED RECEPTOR 124-LIKE PROTEIN ADHESION G PROTEIN-COUPLED RECEPTOR A1 signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166 cell junction#GO:0030054;postsynaptic density#GO:0014069;glutamatergic synapse#GO:0098978;synapse#GO:0045202;cellular anatomical structure#GO:0110165;neuron to neuron synapse#GO:0098984;organelle#GO:0043226;postsynaptic specialization#GO:0099572;asymmetric synapse#GO:0032279;plasma membrane#GO:0005886;membrane#GO:0016020;postsynapse#GO:0098794;cell periphery#GO:0071944 G-protein coupled receptor#PC00021 HUMAN|HGNC=14996|UniProtKB=Q8NGY1 Q8NGY1 OR10Z1 PTHR26451:SF49 G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN OLFACTORY RECEPTOR 10Z1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;binding#GO:0005488 detection of chemical stimulus#GO:0009593;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;response to chemical#GO:0042221;response to stimulus#GO:0050896;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;sensory perception#GO:0007600;nervous system process#GO:0050877;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008 cellular anatomical structure#GO:0110165;membrane#GO:0016020 G-protein coupled receptor#PC00021 HUMAN|HGNC=6398|UniProtKB=O15131 O15131 KPNA5 PTHR23316:SF10 IMPORTIN ALPHA IMPORTIN SUBUNIT ALPHA-6 molecular carrier activity#GO:0140104;nucleocytoplasmic carrier activity#GO:0140142 cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;protein localization to nucleus#GO:0034504;macromolecule localization#GO:0033036;import into nucleus#GO:0051170;transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;protein localization to organelle#GO:0033365;nucleocytoplasmic transport#GO:0006913;protein import into nucleus#GO:0006606;protein transport#GO:0015031;nuclear transport#GO:0051169;cellular localization#GO:0051641;localization#GO:0051179;NLS-bearing protein import into nucleus#GO:0006607 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 transporter#PC00227 HUMAN|HGNC=4200|UniProtKB=P78537 P78537 BLOC1S1 PTHR13073:SF0 BLOC-1 COMPLEX SUBUNIT 1 BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 1 cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;transport#GO:0006810;intracellular transport#GO:0046907;endosomal transport#GO:0016197;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179 protein-containing complex#GO:0032991;BLOC-1 complex#GO:0031083;intracellular protein-containing complex#GO:0140535 membrane traffic protein#PC00150 HUMAN|HGNC=28147|UniProtKB=Q8N9N8 Q8N9N8 EIF1AD PTHR21641:SF0 TRANSLATION INITIATION FACTOR-RELATED RNA-BINDING PROTEIN EIF1AD-RELATED intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 translation initiation factor#PC00224;translation factor#PC00223 HUMAN|HGNC=1230|UniProtKB=Q9UBG3 Q9UBG3 CRNN PTHR11639:SF26 S100 CALCIUM-BINDING PROTEIN CORNULIN cation binding#GO:0043169;protein binding#GO:0005515;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094 cell migration#GO:0016477;endothelial cell migration#GO:0043542;cell motility#GO:0048870;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 calmodulin-related#PC00061;calcium-binding protein#PC00060 HUMAN|HGNC=53959|UniProtKB=A0A8Q3WKH5 A0A8Q3WKH5 H2AL1Q PTHR23430:SF11 HISTONE H2A HISTONE H2A-RELATED structural molecule activity#GO:0005198 heterochromatin formation#GO:0031507;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;epigenetic regulation of gene expression#GO:0040029;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;heterochromatin organization#GO:0070828;chromatin organization#GO:0006325;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;cellular component assembly#GO:0022607;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of gene expression, epigenetic#GO:0045814;cellular component organization or biogenesis#GO:0071840 intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;chromosome#GO:0005694;nucleus#GO:0005634;chromatin#GO:0000785;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;protein-DNA complex#GO:0032993;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;nucleosome#GO:0000786 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=22940|UniProtKB=Q86W28 Q86W28 NLRP8 PTHR45690:SF8 NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12 NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 8 regulation of response to external stimulus#GO:0032101;biological regulation#GO:0065007;regulation of response to stress#GO:0080134;regulation of inflammatory response#GO:0050727;regulation of defense response#GO:0031347;regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090 HUMAN|HGNC=11428|UniProtKB=O60499 O60499 STX10 PTHR19957:SF106 SYNTAXIN SYNTAXIN-10 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;SNAP receptor activity#GO:0005484 vesicle fusion#GO:0006906;cytosolic transport#GO:0016482;cellular component organization#GO:0016043;localization#GO:0051179;cellular localization#GO:0051641;protein transport#GO:0015031;organelle fusion#GO:0048284;vesicle-mediated transport#GO:0016192;membrane organization#GO:0061024;organelle membrane fusion#GO:0090174;organelle organization#GO:0006996;retrograde transport, endosome to Golgi#GO:0042147;macromolecule localization#GO:0033036;membrane fusion#GO:0061025;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;endosomal transport#GO:0016197;vesicle organization#GO:0016050;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810 intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;SNARE complex#GO:0031201;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;synaptic vesicle#GO:0008021;synaptic vesicle membrane#GO:0030672;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;cell junction#GO:0030054;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;transport vesicle membrane#GO:0030658;transport vesicle#GO:0030133;presynapse#GO:0098793;secretory vesicle#GO:0099503;membrane#GO:0016020;vesicle membrane#GO:0012506 SNARE protein#PC00034 Alpha adrenergic receptor signaling pathway#P00002>SNARE#P00074 HUMAN|HGNC=26215|UniProtKB=Q6P4A8 Q6P4A8 PLBD1 PTHR12370:SF1 N-TERMINAL NUCLEOPHILE (NTN) HYDROLASE LYSOSOMAL LEUCINE AMINOPEPTIDASE extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 phospholipase#PC00186 HUMAN|HGNC=11110|UniProtKB=O14497 O14497 ARID1A PTHR12656:SF12 BRG-1 ASSOCIATED FACTOR 250 BAF250 AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 1A protein-containing complex binding#GO:0044877;nucleosome binding#GO:0031491;binding#GO:0005488;chromatin binding#GO:0003682 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254 intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;SWI/SNF superfamily-type complex#GO:0070603;chromosome#GO:0005694;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;SWI/SNF complex#GO:0016514;intracellular organelle#GO:0043229;ATPase complex#GO:1904949;intracellular organelle lumen#GO:0070013;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;chromatin#GO:0000785;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228 Wnt signaling pathway#P00057>SWI/SNF#P01435 HUMAN|HGNC=10612|UniProtKB=Q16627 Q16627 CCL14 PTHR12015:SF110 SMALL INDUCIBLE CYTOKINE A C-C MOTIF CHEMOKINE 14 cytokine activity#GO:0005125;binding#GO:0005488;signaling receptor binding#GO:0005102;cytokine receptor binding#GO:0005126;molecular function activator activity#GO:0140677;protein binding#GO:0005515;chemokine receptor binding#GO:0042379;G protein-coupled receptor binding#GO:0001664;chemokine activity#GO:0008009;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546 response to peptide#GO:1901652;cellular response to chemical stimulus#GO:0070887;immune system process#GO:0002376;G protein-coupled receptor signaling pathway#GO:0007186;granulocyte chemotaxis#GO:0071621;response to stimulus#GO:0050896;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;positive regulation of cell motility#GO:2000147;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;humoral immune response#GO:0006959;antimicrobial humoral response#GO:0019730;cell surface receptor signaling pathway#GO:0007166;granulocyte migration#GO:0097530;defense response to other organism#GO:0098542;response to cytokine#GO:0034097;taxis#GO:0042330;response to chemical#GO:0042221;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;response to chemokine#GO:1990868;cellular process#GO:0009987;signal transduction#GO:0007165;defense response to symbiont#GO:0140546;positive regulation of biological process#GO:0048518;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;cell communication#GO:0007154;regulation of cell motility#GO:2000145;chemokine-mediated signaling pathway#GO:0070098;cell chemotaxis#GO:0060326;cytokine-mediated signaling pathway#GO:0019221;chemotaxis#GO:0006935;inflammatory response#GO:0006954;cell motility#GO:0048870;regulation of cellular process#GO:0050794;locomotion#GO:0040011;cellular response to chemokine#GO:1990869;response to external biotic stimulus#GO:0043207;cellular response to stimulus#GO:0051716;defense response#GO:0006952;leukocyte chemotaxis#GO:0030595;positive regulation of locomotion#GO:0040017;myeloid leukocyte migration#GO:0097529;response to external stimulus#GO:0009605;leukocyte migration#GO:0050900;regulation of cell migration#GO:0030334;cell migration#GO:0016477;response to other organism#GO:0051707;regulation of locomotion#GO:0040012;biological regulation#GO:0065007;positive regulation of cell migration#GO:0030335;positive regulation of cellular process#GO:0048522;immune response#GO:0006955 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 cytokine#PC00083 HUMAN|HGNC=18412|UniProtKB=Q8IUH5 Q8IUH5 ZDHHC17 PTHR24161:SF18 ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED PALMITOYLTRANSFERASE ZDHHC17 acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824;palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity, acting on a protein#GO:0140096 plasma membrane bounded cell projection organization#GO:0120036;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;cellular process#GO:0009987;neuron projection development#GO:0031175;axon development#GO:0061564;cell projection morphogenesis#GO:0048858;neurogenesis#GO:0022008;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;neuron differentiation#GO:0030182;developmental process#GO:0032502;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron projection morphogenesis#GO:0048812;cell development#GO:0048468;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell morphogenesis#GO:0000902;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;system development#GO:0048731;neuron development#GO:0048666;axonogenesis#GO:0007409;anatomical structure development#GO:0048856;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108 membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular organelle#GO:0043229;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227 protein modifying enzyme#PC00260 HUMAN|HGNC=19897|UniProtKB=Q96KE9 Q96KE9 BTBD6 PTHR45774:SF5 BTB/POZ DOMAIN-CONTAINING BTB_POZ DOMAIN-CONTAINING PROTEIN 6 nervous system development#GO:0007399;cell differentiation#GO:0030154;multicellular organismal process#GO:0032501;cellular process#GO:0009987;system development#GO:0048731;neurogenesis#GO:0022008;multicellular organism development#GO:0007275;anatomical structure development#GO:0048856;cellular developmental process#GO:0048869;developmental process#GO:0032502;animal gross anatomical part developmental process#GO:0160108 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=9750|UniProtKB=P20742 P20742 PZP PTHR11412:SF92 MACROGLOBULIN / COMPLEMENT PREGNANCY ZONE PROTEIN enzyme inhibitor activity#GO:0004857;molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866;peptidase regulator activity#GO:0061134;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234 defense response#GO:0006952;response to stimulus#GO:0050896;inflammatory response#GO:0006954;response to stress#GO:0006950 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;extracellular protein-containing complex#GO:0140392;catalytic complex#GO:1902494 protease inhibitor#PC00191 HUMAN|HGNC=16469|UniProtKB=Q15057 Q15057 ACAP2 PTHR23180:SF241 CENTAURIN/ARF ARF-GAP WITH COILED-COIL, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 2 enzyme regulator activity#GO:0030234;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047 actin cytoskeleton organization#GO:0030036;cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;organelle organization#GO:0006996;actin filament-based process#GO:0030029;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;vesicle membrane#GO:0012506;cytoplasm#GO:0005737;plasma membrane#GO:0005886;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;endosome membrane#GO:0010008;endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=12871|UniProtKB=Q9UKY1 Q9UKY1 ZHX1 PTHR15467:SF4 ZINC-FINGERS AND HOMEOBOXES RELATED ZINC FINGERS AND HOMEOBOXES PROTEIN 1 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 homeodomain transcription factor#PC00119;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=4108|UniProtKB=O60829 O60829 PAGE4 PTHR14047:SF11 P ANTIGEN FAMILY MEMBER 5-RELATED P ANTIGEN FAMILY MEMBER 4 HUMAN|HGNC=26623|UniProtKB=Q86X19 Q86X19 TMEM17 PTHR13531:SF14 GEO07735P1-RELATED-RELATED TRANSMEMBRANE PROTEIN 17 non-motile cilium assembly#GO:1905515;cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782;plasma membrane bounded cell projection assembly#GO:0120031;organelle assembly#GO:0070925;cellular component assembly#GO:0022607;cell projection organization#GO:0030030;plasma membrane bounded cell projection organization#GO:0120036;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cell projection assembly#GO:0030031;cellular process#GO:0009987 cell projection#GO:0042995;membrane-bounded organelle#GO:0043227;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cilium#GO:0005929;ciliary transition zone#GO:0035869 HUMAN|HGNC=19692|UniProtKB=Q96F24 Q96F24 NRBF2 PTHR14964:SF5 NUCLEAR RECEPTOR BINDING FACTOR 2 NUCLEAR RECEPTOR-BINDING FACTOR 2 process utilizing autophagic mechanism#GO:0061919;catabolic process#GO:0009056;cellular process#GO:0009987;autophagy#GO:0006914;metabolic process#GO:0008152 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HUMAN|HGNC=15574|UniProtKB=Q8TDY2 Q8TDY2 RB1CC1 PTHR13222:SF5 RB1-INDUCIBLE COILED-COIL RB1-INDUCIBLE COILED-COIL PROTEIN 1 protein binding#GO:0005515;binding#GO:0005488;kinase binding#GO:0019900;protein kinase binding#GO:0019901;enzyme binding#GO:0019899 process utilizing autophagic mechanism#GO:0061919;carbohydrate catabolic process#GO:0016052;glucan catabolic process#GO:0009251;polysaccharide metabolic process#GO:0005976;polysaccharide catabolic process#GO:0000272;glucan metabolic process#GO:0044042;cellular component organization#GO:0016043;autophagosome assembly#GO:0000045;cellular component organization or biogenesis#GO:0071840;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;cellular component assembly#GO:0022607;cellular process#GO:0009987;autophagosome organization#GO:1905037;autophagy#GO:0006914;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;vacuole organization#GO:0007033;energy reserve metabolic process#GO:0006112;organelle assembly#GO:0070925;piecemeal microautophagy of the nucleus#GO:0034727;carbohydrate metabolic process#GO:0005975;catabolic process#GO:0009056;primary metabolic process#GO:0044238;glycogen metabolic process#GO:0005977;energy derivation by oxidation of organic compounds#GO:0015980;pexophagy#GO:0000425;macromolecule metabolic process#GO:0043170;generation of precursor metabolites and energy#GO:0006091;autophagy of mitochondrion#GO:0000422;macroautophagy#GO:0016236;reticulophagy#GO:0061709;glycogen catabolic process#GO:0005980 transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;phagophore assembly site#GO:0000407;transferase complex#GO:1990234;serine/threonine protein kinase complex#GO:1902554;intracellular anatomical structure#GO:0005622;protein kinase complex#GO:1902911;membrane#GO:0016020;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737 scaffold/adaptor protein#PC00226 HUMAN|HGNC=8190|UniProtKB=P47887 P47887 OR1E2 PTHR48001:SF163 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 1E2 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=33728|UniProtKB=A6NJB7 A6NJB7 PRR19 PTHR37346:SF1 PROLINE-RICH PROTEIN 19 PROLINE-RICH PROTEIN 19 HUMAN|HGNC=20477|UniProtKB=Q8TCV5 Q8TCV5 WFDC5 PTHR19441:SF39 WAP four-disulfide core domain protein WAP FOUR-DISULFIDE CORE DOMAIN PROTEIN 5 enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;serine-type endopeptidase inhibitor activity#GO:0004867;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414;peptidase regulator activity#GO:0061134;endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772;enzyme inhibitor activity#GO:0004857 defense response to bacterium#GO:0042742;response to bacterium#GO:0009617;immune system process#GO:0002376;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;response to external stimulus#GO:0009605;defense response#GO:0006952;antibacterial humoral response#GO:0019731;innate immune response#GO:0045087;antimicrobial humoral response#GO:0019730;humoral immune response#GO:0006959;response to other organism#GO:0051707;defense response to other organism#GO:0098542;defense response to symbiont#GO:0140546;immune response#GO:0006955;response to biotic stimulus#GO:0009607;response to stress#GO:0006950 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HUMAN|HGNC=5106|UniProtKB=P20719 P20719 HOXA5 PTHR45659:SF10 HOMEOBOX PROTEIN HOX HOMEOBOX PROTEIN HOX-A5 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;pattern specification process#GO:0007389;regulation of RNA metabolic process#GO:0051252;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regionalization#GO:0003002;multicellular organismal process#GO:0032501;developmental process#GO:0032502;anterior/posterior pattern specification#GO:0009952;regulation of gene expression#GO:0010468;multicellular organism development#GO:0007275;regulation of biosynthetic process#GO:0009889 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119 HUMAN|HGNC=15750|UniProtKB=P60981 P60981 DSTN PTHR11913:SF18 COFILIN-RELATED DESTRIN protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;actin filament binding#GO:0051015;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092 cellular component organization or biogenesis#GO:0071840;cellular component disassembly#GO:0022411;actin filament organization#GO:0007015;supramolecular fiber organization#GO:0097435;protein-containing complex organization#GO:0043933;actin filament-based process#GO:0030029;actin cytoskeleton organization#GO:0030036;protein-containing complex disassembly#GO:0032984;cytoskeleton organization#GO:0007010;protein depolymerization#GO:0051261;organelle organization#GO:0006996;cellular component organization#GO:0016043;actin filament depolymerization#GO:0030042;actin polymerization or depolymerization#GO:0008154;cellular process#GO:0009987 actin cytoskeleton#GO:0015629;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 non-motor actin binding protein#PC00165 HUMAN|HGNC=33725|UniProtKB=Q6ICI0 Q6ICI0 LHFPL7 PTHR12489:SF20 LIPOMA HMGIC FUSION PARTNER-LIKE PROTEIN LHFPL TETRASPAN SUBFAMILY MEMBER 7 PROTEIN membrane#GO:0016020;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=14450|UniProtKB=Q92539 Q92539 LPIN2 PTHR12181:SF11 LIPIN PHOSPHATIDATE PHOSPHATASE LPIN2 hydrolase activity#GO:0016787;transcription regulator activity#GO:0140110;transcription coactivator activity#GO:0003713;phosphoric ester hydrolase activity#GO:0042578;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;transcription coregulator activity#GO:0003712;catalytic activity#GO:0003824 positive regulation of macromolecule metabolic process#GO:0010604;response to chemical#GO:0042221;response to hormone#GO:0009725;lipid catabolic process#GO:0016042;cellular response to oxygen-containing compound#GO:1901701;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;metabolic process#GO:0008152;positive regulation of transcription by RNA polymerase II#GO:0045944;response to stimulus#GO:0050896;small molecule metabolic process#GO:0044281;regulation of transcription by RNA polymerase II#GO:0006357;glycerolipid metabolic process#GO:0046486;cellular response to endogenous stimulus#GO:0071495;cellular response to hormone stimulus#GO:0032870;small molecule catabolic process#GO:0044282;response to endogenous stimulus#GO:0009719;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;regulation of biological process#GO:0050789;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;fatty acid catabolic process#GO:0009062;oxoacid metabolic process#GO:0043436;cellular response to chemical stimulus#GO:0070887;response to oxygen-containing compound#GO:1901700;triglyceride biosynthetic process#GO:0019432;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular response to nitrogen compound#GO:1901699;monocarboxylic acid catabolic process#GO:0072329;lipid biosynthetic process#GO:0008610;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;biosynthetic process#GO:0009058;response to peptide hormone#GO:0043434;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;carboxylic acid catabolic process#GO:0046395;glycerolipid biosynthetic process#GO:0045017;neutral lipid metabolic process#GO:0006638;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;fatty acid metabolic process#GO:0006631;acylglycerol metabolic process#GO:0006639;triglyceride metabolic process#GO:0006641;lipid metabolic process#GO:0006629;cellular response to insulin stimulus#GO:0032869;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;cellular response to peptide hormone stimulus#GO:0071375;positive regulation of RNA metabolic process#GO:0051254;primary metabolic process#GO:0044238;response to insulin#GO:0032868;cellular response to stimulus#GO:0051716;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;response to nitrogen compound#GO:1901698;regulation of RNA metabolic process#GO:0051252 endomembrane system#GO:0012505;cytoplasm#GO:0005737;cytosol#GO:0005829;membrane#GO:0016020;nucleus#GO:0005634;organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229 phosphatase#PC00181;hydrolase#PC00121 HUMAN|HGNC=8853|UniProtKB=O96011 O96011 PEX11B PTHR12652:SF7 PEROXISOMAL BIOGENESIS FACTOR 11 PEROXISOMAL MEMBRANE PROTEIN 11B cellular component organization or biogenesis#GO:0071840;organelle fission#GO:0048285;peroxisome organization#GO:0007031;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;peroxisome#GO:0005777;membrane#GO:0016020;microbody#GO:0042579;organelle#GO:0043226;cellular anatomical structure#GO:0110165;peroxisomal membrane#GO:0005778;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=785|UniProtKB=P18847 P18847 ATF3 PTHR23351:SF23 FOS TRANSCRIPTION FACTOR-RELATED CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-3 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 basic leucine zipper transcription factor#PC00056 Apoptosis signaling pathway#P00006>ATF#P00302;Gonadotropin-releasing hormone receptor pathway#P06664>Atf3#G06902;Gonadotropin-releasing hormone receptor pathway#P06664>Atf3#G06689;Gonadotropin-releasing hormone receptor pathway#P06664>Atf3#P06821 HUMAN|HGNC=3236|UniProtKB=P00533 P00533 EGFR PTHR24416:SF91 TYROSINE-PROTEIN KINASE RECEPTOR EPIDERMAL GROWTH FACTOR RECEPTOR protein binding#GO:0005515;growth factor binding#GO:0019838;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;transferase activity#GO:0016740;kinase activity#GO:0016301;molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714;catalytic activity, acting on a protein#GO:0140096;transmembrane receptor protein kinase activity#GO:0019199;hormone binding#GO:0042562;protein tyrosine kinase activity#GO:0004713;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772 cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of cell population proliferation#GO:0042127;cell communication#GO:0007154;system development#GO:0048731;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;positive regulation of epithelial cell proliferation#GO:0050679;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;developmental process#GO:0032502;positive regulation of MAPK cascade#GO:0043410;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;ERBB signaling pathway#GO:0038127;positive regulation of cellular process#GO:0048522;multicellular organismal process#GO:0032501;epidermal growth factor receptor signaling pathway#GO:0007173;positive regulation of response to stimulus#GO:0048584;negative regulation of apoptotic process#GO:0043066;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;animal gross anatomical part developmental process#GO:0160108;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;generation of neurons#GO:0048699;positive regulation of signaling#GO:0023056;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;positive regulation of cell population proliferation#GO:0008284;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cell differentiation#GO:0030154;signaling#GO:0023052;cell surface receptor signaling pathway#GO:0007166;regulation of apoptotic process#GO:0042981;regulation of MAPK cascade#GO:0043408;neuron differentiation#GO:0030182;multicellular organism development#GO:0007275;cellular process#GO:0009987;negative regulation of programmed cell death#GO:0043069;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;nervous system development#GO:0007399 signaling receptor complex#GO:0043235;basal plasma membrane#GO:0009925;cell periphery#GO:0071944;basal part of cell#GO:0045178;membrane#GO:0016020;plasma membrane#GO:0005886;plasma membrane region#GO:0098590;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 Cadherin signaling pathway#P00012>EGFR#P00466;EGF receptor signaling pathway#P00018>EGFR#P00542;Gonadotropin-releasing hormone receptor pathway#P06664>EGFR#P06843 HUMAN|HGNC=2515|UniProtKB=O60716 O60716 CTNND1 PTHR10372:SF6 PLAKOPHILLIN-RELATED CATENIN DELTA-1 protein binding#GO:0005515;cell adhesion molecule binding#GO:0050839;binding#GO:0005488 cell adhesion#GO:0007155;cellular process#GO:0009987;cell-cell adhesion#GO:0098609 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;cell periphery#GO:0071944;membrane#GO:0016020;cell-cell junction#GO:0005911;anchoring junction#GO:0070161;intracellular anatomical structure#GO:0005622;adherens junction#GO:0005912;membrane-bounded organelle#GO:0043227;cell junction#GO:0030054;intracellular organelle#GO:0043229 intermediate filament binding protein#PC00130;cytoskeletal protein#PC00085;intermediate filament#PC00129 Cadherin signaling pathway#P00012>P120#P00473 HUMAN|HGNC=30914|UniProtKB=Q8TAF3 Q8TAF3 WDR48 PTHR19862:SF14 WD REPEAT-CONTAINING PROTEIN 48 WD REPEAT-CONTAINING PROTEIN 48 protein binding#GO:0005515;binding#GO:0005488;ubiquitin binding#GO:0043130 cellular response to stress#GO:0033554;recombinational repair#GO:0000725;response to stimulus#GO:0050896;double-strand break repair via homologous recombination#GO:0000724;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;DNA recombination#GO:0006310;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;response to stress#GO:0006950 HUMAN|HGNC=2932|UniProtKB=Q13316 Q13316 DMP1 PTHR23400:SF0 DENTIN MATRIX ACIDIC PHOSPHOPROTEIN 1 DENTIN MATRIX ACIDIC PHOSPHOPROTEIN 1 binding#GO:0005488;extracellular matrix binding#GO:0050840 extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;external encapsulating structure organization#GO:0045229;extracellular structure organization#GO:0043062;cellular component organization#GO:0016043;cellular process#GO:0009987 extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cellular anatomical structure#GO:0110165 HUMAN|HGNC=8615|UniProtKB=P15863 P15863 PAX1 PTHR45636:SF15 PAIRED BOX PROTEIN PAX-6-RELATED-RELATED PAIRED BOX PROTEIN PAX-1 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 embryo development ending in birth or egg hatching#GO:0009792;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;skeletal system development#GO:0001501;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;developmental process#GO:0032502;regulation of gene expression#GO:0010468;multicellular organism development#GO:0007275;regulation of biosynthetic process#GO:0009889;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;embryo development#GO:0009790;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 HUMAN|HGNC=23028|UniProtKB=Q9H4A9 Q9H4A9 DPEP2 PTHR10443:SF9 MICROSOMAL DIPEPTIDASE DIPEPTIDASE 2 peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;exopeptidase activity#GO:0008238;hydrolase activity#GO:0016787;catalytic activity#GO:0003824 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 protease#PC00190;protein modifying enzyme#PC00260 HUMAN|HGNC=25078|UniProtKB=O75425 O75425 MOSPD3 PTHR34441:SF4 MOTILE SPERM DOMAIN-CONTAINING PROTEIN 1 MOTILE SPERM DOMAIN-CONTAINING PROTEIN 3 HUMAN|HGNC=17149|UniProtKB=Q96IQ7 Q96IQ7 VSIG2 PTHR45046:SF1 V-SET AND IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN 2 V-SET AND IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN 2 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=1916|UniProtKB=Q86WJ1 Q86WJ1 CHD1L PTHR47157:SF1 CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1-LIKE ATP-DEPENDENT CHROMATIN REMODELER CHD1L nucleoside phosphate binding#GO:1901265;small molecule binding#GO:0036094;binding#GO:0005488;nucleotide binding#GO:0000166;heterocyclic compound binding#GO:1901363 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stress#GO:0006950;cellular component organization#GO:0016043;chromatin organization#GO:0006325;chromatin remodeling#GO:0006338;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;cellular component organization or biogenesis#GO:0071840 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 chromatin/chromatin-binding, or -regulatory protein#PC00077 Wnt signaling pathway#P00057>SWI/SNF#P01435 HUMAN|HGNC=17587|UniProtKB=Q9Y6C9 Q9Y6C9 MTCH2 PTHR10780:SF20 MITOCHONDRIAL CARRIER HOMOLOG MITOCHONDRIAL CARRIER HOMOLOG 2 molecular carrier activity#GO:0140104;protein carrier activity#GO:0140597;membrane insertase activity#GO:0032977 protein insertion into membrane#GO:0051205;biological regulation#GO:0065007;mitochondrion organization#GO:0007005;membrane organization#GO:0061024;macromolecule localization#GO:0033036;establishment of protein localization to membrane#GO:0090150;organelle organization#GO:0006996;cellular process#GO:0009987;mitochondrial membrane organization#GO:0007006;establishment of protein localization#GO:0045184;positive regulation of cellular process#GO:0048522;establishment of localization in cell#GO:0051649;positive regulation of biological process#GO:0048518;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;positive regulation of apoptotic process#GO:0043065;cellular component organization or biogenesis#GO:0071840;intracellular protein localization#GO:0008104;regulation of apoptotic process#GO:0042981;positive regulation of programmed cell death#GO:0043068;regulation of cellular process#GO:0050794;protein localization to organelle#GO:0033365;cellular component organization#GO:0016043;regulation of programmed cell death#GO:0043067;protein localization to mitochondrion#GO:0070585;regulation of biological process#GO:0050789;cellular localization#GO:0051641;localization#GO:0051179;localization within membrane#GO:0051668;protein insertion into mitochondrial outer membrane#GO:0045040 mitochondrion#GO:0005739;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;outer membrane#GO:0019867;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;membrane#GO:0016020;cytoplasm#GO:0005737;organelle outer membrane#GO:0031968;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;mitochondrial outer membrane#GO:0005741 mitochondrial carrier protein#PC00158;secondary carrier transporter#PC00258 HUMAN|HGNC=24305|UniProtKB=Q15021 Q15021 NCAPD2 PTHR14222:SF2 CONDENSIN CONDENSIN COMPLEX SUBUNIT 1 protein binding#GO:0005515;binding#GO:0005488;histone binding#GO:0042393 cellular process#GO:0009987;mitotic sister chromatid segregation#GO:0000070;organelle organization#GO:0006996;mitotic cell cycle process#GO:1903047;chromosome organization#GO:0051276;cellular component organization or biogenesis#GO:0071840;chromosome segregation#GO:0007059;chromosome organization involved in meiotic cell cycle#GO:0070192;meiotic cell cycle#GO:0051321;reproductive process#GO:0022414;mitotic cell cycle#GO:0000278;cell cycle process#GO:0022402;mitotic nuclear division#GO:0140014;cell cycle#GO:0007049;meiotic cell cycle process#GO:1903046;nuclear chromosome segregation#GO:0098813;cellular component organization#GO:0016043;sister chromatid segregation#GO:0000819;mitotic chromosome condensation#GO:0007076;chromosome condensation#GO:0030261;organelle fission#GO:0048285;sexual reproduction#GO:0019953;nuclear division#GO:0000280 condensin complex#GO:0000796;intracellular organelle#GO:0043229;condensed chromosome#GO:0000793;chromosome, centromeric region#GO:0000775;intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687;membraneless organelle#GO:0043228;condensed chromosome, centromeric region#GO:0000779;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=7216|UniProtKB=P34949 P34949 MPI PTHR10309:SF0 MANNOSE-6-PHOSPHATE ISOMERASE MANNOSE-6-PHOSPHATE ISOMERASE isomerase activity#GO:0016853;intramolecular oxidoreductase activity#GO:0016860;intramolecular oxidoreductase activity, interconverting aldoses and ketoses#GO:0016861;catalytic activity#GO:0003824 organophosphate biosynthetic process#GO:0090407;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;carbohydrate derivative biosynthetic process#GO:1901137;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing small molecule metabolic process#GO:0055086;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;nucleotide-sugar metabolic process#GO:0009225;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 isomerase#PC00135;metabolite interconversion enzyme#PC00262 Mannose metabolism#P02752>Mannose 6-P isomerase#P03017 HUMAN|HGNC=13394|UniProtKB=Q9NP85 Q9NP85 NPHS2 PTHR10264:SF135 BAND 7 PROTEIN-RELATED PODOCIN channel regulator activity#GO:0016247;molecular function regulator activity#GO:0098772;molecular function inhibitor activity#GO:0140678;transporter regulator activity#GO:0141108;ion channel inhibitor activity#GO:0008200;ion channel regulator activity#GO:0099106 developmental process#GO:0032502;animal gross anatomical part developmental process#GO:0160108;renal system development#GO:0072001;system development#GO:0048731;anatomical structure development#GO:0048856;multicellular organismal process#GO:0032501;multicellular organism development#GO:0007275 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cytoskeletal protein#PC00085 HUMAN|HGNC=10385|UniProtKB=P25398 P25398 RPS12 PTHR11843:SF19 40S RIBOSOMAL PROTEIN S12 SMALL RIBOSOMAL SUBUNIT PROTEIN ES12 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component biogenesis#GO:0044085;ribonucleoprotein complex biogenesis#GO:0022613;biosynthetic process#GO:0009058;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;translation#GO:0006412;ribosomal small subunit biogenesis#GO:0042274;ribosome biogenesis#GO:0042254;metabolic process#GO:0008152;protein metabolic process#GO:0019538;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170 intracellular organelle#GO:0043229;small ribosomal subunit#GO:0015935;cytosolic small ribosomal subunit#GO:0022627;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;ribosome#GO:0005840;cytosolic ribosome#GO:0022626;cytosol#GO:0005829;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226 ribosomal protein#PC00202;translational protein#PC00263 HUMAN|HGNC=5269|UniProtKB=P61604 P61604 HSPE1 PTHR10772:SF67 10 KDA HEAT SHOCK PROTEIN 10 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL small molecule binding#GO:0036094;binding#GO:0005488;protein-folding chaperone binding#GO:0051087;ion binding#GO:0043167;cation binding#GO:0043169;metal ion binding#GO:0046872;protein binding#GO:0005515 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;protein folding#GO:0006457;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 chaperonin#PC00073 HUMAN|HGNC=25764|UniProtKB=Q9H9A7 Q9H9A7 RMI1 PTHR14790:SF15 RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1 RMI1 RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1 double-strand break repair#GO:0006302;cellular component organization or biogenesis#GO:0071840;DNA recombination#GO:0006310;meiotic cell cycle#GO:0051321;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;cellular process#GO:0009987;organelle organization#GO:0006996;response to stress#GO:0006950;cellular response to stress#GO:0033554;reciprocal meiotic recombination#GO:0007131;nuclear division#GO:0000280;response to stimulus#GO:0050896;cell cycle process#GO:0022402;double-strand break repair via homologous recombination#GO:0000724;meiosis I#GO:0007127;cellular component organization#GO:0016043;meiotic cell cycle process#GO:1903046;macromolecule metabolic process#GO:0043170;meiotic nuclear division#GO:0140013;DNA damage response#GO:0006974;DNA repair#GO:0006281;nucleobase-containing compound metabolic process#GO:0006139;resolution of meiotic recombination intermediates#GO:0000712;organelle fission#GO:0048285;sexual reproduction#GO:0019953;meiosis I cell cycle process#GO:0061982;recombinational repair#GO:0000725;reproductive process#GO:0022414;homologous recombination#GO:0035825;reciprocal homologous recombination#GO:0140527;cellular response to stimulus#GO:0051716;cell cycle#GO:0007049;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;nuclear body#GO:0016604;membraneless organelle#GO:0043228;organelle lumen#GO:0043233;chromosome#GO:0005694;DNA helicase complex#GO:0033202;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=1785|UniProtKB=P46527 P46527 CDKN1B PTHR10265:SF9 CYCLIN-DEPENDENT KINASE INHIBITOR 1 CYCLIN-DEPENDENT KINASE INHIBITOR 1B enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;kinase inhibitor activity#GO:0019210;kinase regulator activity#GO:0019207;cyclin-dependent protein serine/threonine kinase inhibitor activity#GO:0004861;molecular function regulator activity#GO:0098772;protein kinase inhibitor activity#GO:0004860;protein kinase regulator activity#GO:0019887;cyclin-dependent protein kinase regulator activity#GO:0019914;cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538;enzyme inhibitor activity#GO:0004857 regulation of mitotic cell cycle#GO:0007346;negative regulation of mitotic cell cycle phase transition#GO:1901991;biological regulation#GO:0065007;regulation of cell cycle process#GO:0010564;negative regulation of cellular process#GO:0048523;negative regulation of cell cycle process#GO:0010948;negative regulation of cell cycle#GO:0045786;negative regulation of biological process#GO:0048519;regulation of cell cycle phase transition#GO:1901987;negative regulation of cell cycle phase transition#GO:1901988;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cell cycle G1/S phase transition#GO:1902806;regulation of cell cycle#GO:0051726;regulation of G1/S transition of mitotic cell cycle#GO:2000045;regulation of mitotic cell cycle phase transition#GO:1901990;negative regulation of mitotic cell cycle#GO:0045930 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 kinase inhibitor#PC00139;kinase modulator#PC00140 Interleukin signaling pathway#P00036>p27KIP1#P00982 HUMAN|HGNC=53430|UniProtKB=A0A1B0GVZ2 A0A1B0GVZ2 FAM240B PTHR40387:SF1 PROTEIN FAM240B PROTEIN FAM240B HUMAN|HGNC=7137|UniProtKB=P55196 P55196 AFDN PTHR10398:SF2 AFADIN AFADIN protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;cytoskeletal adaptor activity#GO:0008093 cell junction organization#GO:0034330;cell-cell adhesion#GO:0098609;cellular component organization#GO:0016043;adherens junction organization#GO:0034332;cellular process#GO:0009987;cell-cell junction maintenance#GO:0045217;cellular component organization or biogenesis#GO:0071840;cell adhesion#GO:0007155;cell-cell junction organization#GO:0045216 plasma membrane#GO:0005886;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cell cortex#GO:0005938;cell periphery#GO:0071944;membrane#GO:0016020;cell-cell junction#GO:0005911;adherens junction#GO:0005912;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;cell junction#GO:0030054 non-motor actin binding protein#PC00165;actin or actin-binding cytoskeletal protein#PC00041 Alzheimer disease-presenilin pathway#P00004>Afadin#P00146 HUMAN|HGNC=18889|UniProtKB=Q6J9G0 Q6J9G0 STYK1 PTHR24418:SF269 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE STYK1 catalytic activity#GO:0003824;transferase activity#GO:0016740;protein tyrosine kinase activity#GO:0004713;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;non-membrane spanning protein tyrosine kinase activity#GO:0004715;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 non-receptor tyrosine protein kinase#PC00168 HUMAN|HGNC=7977|UniProtKB=P10588 P10588 NR2F6 PTHR24083:SF44 NUCLEAR HORMONE RECEPTOR NUCLEAR RECEPTOR SUBFAMILY 2 GROUP F MEMBER 6 cis-regulatory region sequence-specific DNA binding#GO:0000987;molecular transducer activity#GO:0060089;nuclear receptor activity#GO:0004879;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulatory region nucleic acid binding#GO:0001067;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023 developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;negative regulation of transcription by RNA polymerase II#GO:0000122;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;multicellular organism development#GO:0007275;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;nervous system development#GO:0007399;animal gross anatomical part developmental process#GO:0160108;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 gene-specific transcriptional regulator#PC00264;C4 zinc finger nuclear receptor#PC00169 HUMAN|HGNC=8223|UniProtKB=Q15612 Q15612 OR1Q1 PTHR48001:SF56 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 1Q1 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell communication#GO:0007154 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=18512|UniProtKB=Q53H82 Q53H82 LACTB2 PTHR23131:SF6 ENDORIBONUCLEASE LACTB2 ENDORIBONUCLEASE LACTB2 binding#GO:0005488;nucleic acid binding#GO:0003676;nuclease activity#GO:0004518;RNA binding#GO:0003723;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on RNA#GO:0140098;RNA endonuclease activity#GO:0004521;single-stranded RNA binding#GO:0003727;endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 endoribonuclease#PC00094;RNA metabolism protein#PC00031 HUMAN|HGNC=2553|UniProtKB=Q13618 Q13618 CUL3 PTHR11932:SF180 CULLIN CULLIN-3 protein binding#GO:0005515;ubiquitin protein ligase binding#GO:0031625;structural molecule activity#GO:0005198;ubiquitin-like protein ligase binding#GO:0044389;binding#GO:0005488;enzyme binding#GO:0019899;protein complex scaffold activity#GO:0140378 protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;protein modification process#GO:0036211;primary metabolic process#GO:0044238;catabolic process#GO:0009056;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;cellular process#GO:0009987;protein ubiquitination#GO:0016567;proteasomal protein catabolic process#GO:0010498;post-translational protein modification#GO:0043687;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170 transferase complex#GO:1990234;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;Cul3-RING ubiquitin ligase complex#GO:0031463;ubiquitin ligase complex#GO:0000151;nucleus#GO:0005634;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=1717|UniProtKB=Q16181 Q16181 SEPTIN7 PTHR18884:SF137 SEPTIN SEPTIN-7 hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787 intracellular protein localization#GO:0008104;localization#GO:0051179;cytoskeleton-dependent cytokinesis#GO:0061640;cytokinesis#GO:0000910;cell cycle process#GO:0022402;cellular process#GO:0009987;cell division#GO:0051301;macromolecule localization#GO:0033036;cell cycle#GO:0007049 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;microtubule cytoskeleton#GO:0015630;cell cortex#GO:0005938;cell periphery#GO:0071944;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;cell division site#GO:0032153;cytoplasm#GO:0005737 cytoskeletal protein#PC00085 HUMAN|HGNC=9606|UniProtKB=P01270 P01270 PTH PTHR10541:SF2 PARATHYROID HORMONE PARATHYROID HORMONE signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;hormone activity#GO:0005179 regulation of multicellular organismal process#GO:0051239;monoatomic ion homeostasis#GO:0050801;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;renal system process#GO:0003014;intracellular calcium ion homeostasis#GO:0006874;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;chemical homeostasis#GO:0048878;response to stimulus#GO:0050896;signaling#GO:0023052;intracellular monoatomic ion homeostasis#GO:0006873;regulation of biological process#GO:0050789;positive regulation of multicellular organismal process#GO:0051240;regulation of multicellular organismal development#GO:2000026;G protein-coupled receptor signaling pathway#GO:0007186;calcium ion homeostasis#GO:0055074;inorganic ion homeostasis#GO:0098771;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;regulation of bone mineralization#GO:0030500;renal absorption#GO:0070293;system process#GO:0003008;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;positive regulation of developmental process#GO:0051094;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;regulation of cellular process#GO:0050794;homeostatic process#GO:0042592;regulation of developmental process#GO:0050793;cellular response to stimulus#GO:0051716;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207;peptide hormone#PC00179 HUMAN|HGNC=7453|UniProtKB=Q9Y217 Q9Y217 MTMR6 PTHR10807:SF34 MYOTUBULARIN-RELATED PHOSPHATIDYLINOSITOL-3,5-BISPHOSPHATE 3-PHOSPHATASE MTMR6 phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578 primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;phosphate-containing compound metabolic process#GO:0006796;phospholipid dephosphorylation#GO:0046839;glycerophospholipid metabolic process#GO:0006650;glycerolipid metabolic process#GO:0046486;phospholipid metabolic process#GO:0006644;phosphatidylinositol dephosphorylation#GO:0046856;metabolic process#GO:0008152;phosphatidylinositol metabolic process#GO:0046488;lipid metabolic process#GO:0006629;lipid modification#GO:0030258;dephosphorylation#GO:0016311 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle envelope#GO:0031967;membrane#GO:0016020;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 phosphatase#PC00181 HUMAN|HGNC=8671|UniProtKB=Q9Y5H7 Q9Y5H7 PCDHA5 PTHR24028:SF111 CADHERIN-87A PROTOCADHERIN ALPHA-5 cellular process#GO:0009987;cell adhesion#GO:0007155 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 cell adhesion molecule#PC00069;cadherin#PC00057 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HUMAN|HGNC=2915|UniProtKB=Q07687 Q07687 DLX2 PTHR24327:SF23 HOMEOBOX PROTEIN HOMEOBOX PROTEIN DLX-2 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;embryo development#GO:0009790;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;regulation of gene expression#GO:0010468;developmental process#GO:0032502;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;skeletal system development#GO:0001501;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;chordate embryonic development#GO:0043009;embryo development ending in birth or egg hatching#GO:0009792 gene-specific transcriptional regulator#PC00264;helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=19622|UniProtKB=Q8NG78 Q8NG78 OR8G5 PTHR48018:SF48 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 8G5 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;cellular process#GO:0009987;signal transduction#GO:0007165;cell communication#GO:0007154;nervous system process#GO:0050877;sensory perception#GO:0007600;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052;regulation of cellular process#GO:0050794;sensory perception of smell#GO:0007608;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=16207|UniProtKB=Q2PPJ7 Q2PPJ7 RALGAPA2 PTHR10063:SF2 TUBERIN RAL GTPASE-ACTIVATING PROTEIN SUBUNIT ALPHA-2 enzyme activator activity#GO:0008047;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;intracellular signaling cassette#GO:0141124;small GTPase-mediated signal transduction#GO:0007264;signaling#GO:0023052;biological regulation#GO:0065007;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 GTPase-activating protein#PC00257;G-protein modulator#PC00022 HUMAN|HGNC=24704|UniProtKB=Q659C4 Q659C4 LARP1B PTHR22792:SF50 LUPUS LA PROTEIN-RELATED LA-RELATED PROTEIN 1B RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 RNA metabolism protein#PC00031 HUMAN|HGNC=22941|UniProtKB=Q7RTR0 Q7RTR0 NLRP9 PTHR45690:SF13 NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12 NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 9 regulation of response to external stimulus#GO:0032101;biological regulation#GO:0065007;regulation of response to stress#GO:0080134;regulation of inflammatory response#GO:0050727;regulation of defense response#GO:0031347;regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;canonical inflammasome complex#GO:0061702;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytosol#GO:0005829 defense/immunity protein#PC00090 HUMAN|HGNC=7034|UniProtKB=P55082 P55082 MFAP3 PTHR14340:SF4 MICROFIBRIL-ASSOCIATED GLYCOPROTEIN 3 MICROFIBRIL-ASSOCIATED GLYCOPROTEIN 3 HUMAN|HGNC=6465|UniProtKB=Q8IVT5 Q8IVT5 KSR1 PTHR23257:SF716 SERINE-THREONINE PROTEIN KINASE KINASE SUPPRESSOR OF RAS 1 phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;protein kinase activity#GO:0004672;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;Ras protein signal transduction#GO:0007265;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;intracellular signaling cassette#GO:0141124;small GTPase-mediated signal transduction#GO:0007264;signaling#GO:0023052;biological regulation#GO:0065007;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 Gonadotropin-releasing hormone receptor pathway#P06664>KSR-1#P06842 HUMAN|HGNC=20116|UniProtKB=Q8N8R3 Q8N8R3 SLC25A29 PTHR45624:SF61 MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER basic amino acid transmembrane transporter activity#GO:0015174;L-amino acid transmembrane transporter activity#GO:0015179;amino acid transmembrane transporter activity#GO:0015171;carboxylic acid transmembrane transporter activity#GO:0046943;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 mitochondrial transmembrane transport#GO:1990542;amino acid transmembrane transport#GO:0003333;transmembrane transport#GO:0055085;cellular localization#GO:0051641;localization#GO:0051179;L-alpha-amino acid transmembrane transport#GO:1902475;mitochondrial transport#GO:0006839;carboxylic acid transmembrane transport#GO:1905039;intracellular transport#GO:0046907;amino acid transport#GO:0006865;organic acid transport#GO:0015849;carboxylic acid transport#GO:0046942;transport#GO:0006810;establishment of localization#GO:0051234;nitrogen compound transport#GO:0071705;L-amino acid transport#GO:0015807;cellular process#GO:0009987;establishment of localization in cell#GO:0051649 mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 transporter#PC00227 HUMAN|HGNC=17012|UniProtKB=O95684 O95684 CEP43 PTHR15431:SF9 FGFR1 ONCOGENE PARTNER/LISH DOMAIN-CONTAINING PROTEIN CENTROSOMAL PROTEIN 43 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;centrosome#GO:0005813;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630 HUMAN|HGNC=23241|UniProtKB=Q8NB50 Q8NB50 ZFP62 PTHR24376:SF77 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 62 HOMOLOG C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=23187|UniProtKB=Q8WY91 Q8WY91 THAP4 PTHR15854:SF4 THAP4 PROTEIN PEROXYNITRITE ISOMERASE THAP4 HUMAN|HGNC=9059|UniProtKB=Q15147 Q15147 PLCB4 PTHR10336:SF36 PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN 1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4 phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity, acting on ester bonds#GO:0016788;phospholipase activity#GO:0120569;glycerophospholipase activity#GO:0004620;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;lipase activity#GO:0016298 calcium ion transport#GO:0006816;calcium ion transmembrane import into cytosol#GO:0097553;metabolic process#GO:0008152;monoatomic cation transmembrane transport#GO:0098655;glycerophospholipid metabolic process#GO:0006650;cellular process#GO:0009987;release of sequestered calcium ion into cytosol#GO:0051209;signal transduction#GO:0007165;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;signaling#GO:0023052;response to stimulus#GO:0050896;glycerolipid metabolic process#GO:0046486;regulation of biological process#GO:0050789;phosphorus metabolic process#GO:0006793;calcium ion transmembrane transport#GO:0070588;establishment of localization#GO:0051234;phosphatidylinositol metabolic process#GO:0046488;lipid metabolic process#GO:0006629;transport#GO:0006810;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;organophosphate metabolic process#GO:0019637;intracellular signal transduction#GO:0035556;monoatomic cation transport#GO:0006812;localization#GO:0051179;cell communication#GO:0007154;metal ion transport#GO:0030001;phospholipid metabolic process#GO:0006644;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238 metabolite interconversion enzyme#PC00262;phospholipase#PC00186;lipase#PC00143;hydrolase#PC00121 Oxytocin receptor mediated signaling pathway#P04391>PLC beta#P04530;Metabotropic glutamate receptor group I pathway#P00041>PLC#P01053;Alpha adrenergic receptor signaling pathway#P00002>PLC#P00073;Thyrotropin-releasing hormone receptor signaling pathway#P04394>PLC#P04581;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Phospholipase C-beta#P00744;Histamine H1 receptor mediated signaling pathway#P04385>PLC#P04484;Endothelin signaling pathway#P00019>PLCbeta#P00591;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>PLC#P01068;5HT2 type receptor mediated signaling pathway#P04374>PLC#P04412;Wnt signaling pathway#P00057>Phospholipase C#P01443;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PLCbetagamma#P00874 HUMAN|HGNC=6490|UniProtKB=Q13751 Q13751 LAMB3 PTHR10574:SF268 NETRIN/LAMININ-RELATED LAMININ SUBUNIT BETA-3 extracellular structure organization#GO:0043062;animal gross anatomical part developmental process#GO:0160108;cell adhesion#GO:0007155;generation of neurons#GO:0048699;axonogenesis#GO:0007409;neuron development#GO:0048666;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell morphogenesis#GO:0000902;cell development#GO:0048468;substrate adhesion-dependent cell spreading#GO:0034446;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cell projection morphogenesis#GO:0048858;neuron projection development#GO:0031175;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cellular component assembly#GO:0022607;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;cell-substrate adhesion#GO:0031589;extracellular matrix organization#GO:0030198;anatomical structure development#GO:0048856;external encapsulating structure organization#GO:0045229;system development#GO:0048731;cell motility#GO:0048870;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;cellular developmental process#GO:0048869;neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;axon development#GO:0061564;axon guidance#GO:0007411;tissue development#GO:0009888;multicellular organismal process#GO:0032501;extracellular matrix assembly#GO:0085029;cell migration#GO:0016477;plasma membrane bounded cell projection organization#GO:0120036 extracellular protein-containing complex#GO:0140392;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;basement membrane#GO:0005604;supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 extracellular matrix protein#PC00102 Integrin signalling pathway#P00034>Laminin#P00947 HUMAN|HGNC=30886|UniProtKB=Q6NSW5 Q6NSW5 DENND10P1 PTHR28544:SF1 PROTEIN FAM45A-RELATED DENN DOMAIN-CONTAINING PROTEIN 10-RELATED GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085;binding#GO:0005488;enzyme binding#GO:0019899;enzyme regulator activity#GO:0030234;small GTPase binding#GO:0031267;protein binding#GO:0005515 macromolecule localization#GO:0033036;establishment of protein localization#GO:0045184;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;transport#GO:0006810;establishment of localization#GO:0051234;localization#GO:0051179;protein transport#GO:0015031;regulation of localization#GO:0032879;intracellular protein localization#GO:0008104;regulation of transport#GO:0051049 cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;late endosome#GO:0005770;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular vesicle#GO:0097708;vesicle#GO:0031982 HUMAN|HGNC=19068|UniProtKB=Q8N6F8 Q8N6F8 METTL27 PTHR43591:SF101 METHYLTRANSFERASE METHYLTRANSFERASE-LIKE PROTEIN 27 transferase#PC00220;methyltransferase#PC00155 HUMAN|HGNC=41985|UniProtKB=C9JG80 C9JG80 NPIPB4 PTHR15438:SF5 NUCLEAR PORE COMPLEX INTERACTING PROTEIN NUCLEAR PORE COMPLEX INTERACTING PROTEIN FAMILY MEMBER B3-RELATED HUMAN|HGNC=21018|UniProtKB=P59923 P59923 ZNF445 PTHR24376:SF262 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 445 regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;cellular component organization or biogenesis#GO:0071840;negative regulation of gene expression, epigenetic#GO:0045814;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of macromolecule biosynthetic process#GO:0010556;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;chromatin organization#GO:0006325;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=15926|UniProtKB=Q9NZ72 Q9NZ72 STMN3 PTHR10104:SF17 STATHMIN STATHMIN-3 binding#GO:0005488;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515 protein-containing complex disassembly#GO:0032984;regulation of cellular process#GO:0050794;regulation of cytoskeleton organization#GO:0051493;system development#GO:0048731;supramolecular fiber organization#GO:0097435;microtubule cytoskeleton organization#GO:0000226;anatomical structure development#GO:0048856;regulation of microtubule-based process#GO:0032886;protein depolymerization#GO:0051261;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;microtubule polymerization or depolymerization#GO:0031109;neurogenesis#GO:0022008;regulation of microtubule polymerization or depolymerization#GO:0031110;cellular developmental process#GO:0048869;developmental process#GO:0032502;cell development#GO:0048468;cell differentiation#GO:0030154;cell projection organization#GO:0030030;regulation of cellular component organization#GO:0051128;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;neuron development#GO:0048666;cellular component disassembly#GO:0022411;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;nervous system development#GO:0007399;regulation of microtubule cytoskeleton organization#GO:0070507;cytoskeleton organization#GO:0007010;microtubule depolymerization#GO:0007019;cellular process#GO:0009987;neuron projection development#GO:0031175;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;microtubule-based process#GO:0007017;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;neuron differentiation#GO:0030182 neuron projection#GO:0043005;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165 non-motor microtubule binding protein#PC00166;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=37214|UniProtKB=B2RXH4 B2RXH4 BTBD18 PTHR47639:SF1 BTB/POZ DOMAIN-CONTAINING PROTEIN 18 BTB_POZ DOMAIN-CONTAINING PROTEIN 18 cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;gene expression#GO:0010467;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;negative regulation of metabolic process#GO:0009892;gamete generation#GO:0007276;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;negative regulation of macromolecule metabolic process#GO:0010605;macromolecule biosynthetic process#GO:0009059;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biosynthetic process#GO:0009058;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;male gamete generation#GO:0048232;developmental process#GO:0032502;spermatogenesis#GO:0007283;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;developmental process involved in reproduction#GO:0003006;RNA biosynthetic process#GO:0032774;reproductive process#GO:0022414;DNA-templated transcription#GO:0006351;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;sexual reproduction#GO:0019953;multicellular organismal reproductive process#GO:0048609 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=1936|UniProtKB=Q13231 Q13231 CHIT1 PTHR11177:SF407 CHITINASE CHITOTRIOSIDASE-1 hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;chitinase activity#GO:0004568;catalytic activity#GO:0003824;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787 carbohydrate derivative catabolic process#GO:1901136;catabolic process#GO:0009056;amino sugar metabolic process#GO:0006040;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;chitin catabolic process#GO:0006032;aminoglycan catabolic process#GO:0006026;amino sugar catabolic process#GO:0046348;chitin metabolic process#GO:0006030;aminoglycan metabolic process#GO:0006022;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 glycosidase#PC00110;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=12627|UniProtKB=Q13107 Q13107 USP4 PTHR21646:SF45 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 4 hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;cysteine-type deubiquitinase activity#GO:0004843;cysteine-type peptidase activity#GO:0008234 RNA metabolic process#GO:0016070;regulation of biological quality#GO:0065008;nucleic acid biosynthetic process#GO:0141187;ribonucleoprotein complex biogenesis#GO:0022613;mRNA metabolic process#GO:0016071;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;mRNA splicing, via spliceosome#GO:0000398;protein-RNA complex organization#GO:0071826;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;gene expression#GO:0010467;cellular component assembly#GO:0022607;RNA processing#GO:0006396;cellular component biogenesis#GO:0044085;mRNA processing#GO:0006397;cellular process#GO:0009987;regulation of protein stability#GO:0031647;protein-RNA complex assembly#GO:0022618;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA splicing, via transesterification reactions#GO:0000375;spliceosomal snRNP assembly#GO:0000387;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;macromolecule metabolic process#GO:0043170;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;biological regulation#GO:0065007;macromolecule biosynthetic process#GO:0009059 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 cysteine protease#PC00081 HUMAN|HGNC=24519|UniProtKB=Q6NUS6 Q6NUS6 TCTN3 PTHR14611:SF4 TECTONIC FAMILY MEMBER TECTONIC-3 cellular component assembly#GO:0022607;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cell projection assembly#GO:0030031;signal transduction#GO:0007165;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection assembly#GO:0120031;cell surface receptor signaling pathway#GO:0007166;cell projection organization#GO:0030030;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;cellular component organization#GO:0016043;cilium assembly#GO:0060271;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;smoothened signaling pathway#GO:0007224;cilium organization#GO:0044782;organelle assembly#GO:0070925 HUMAN|HGNC=37248|UniProtKB=B3KS81 B3KS81 SRRM5 PTHR39414:SF1 SERINE/ARGININE REPETITIVE MATRIX PROTEIN 5-RELATED SERINE_ARGININE REPETITIVE MATRIX PROTEIN 5 HUMAN|HGNC=15090|UniProtKB=Q8N148 Q8N148 OR6V1 PTHR26454:SF10 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 6V1 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=28817|UniProtKB=Q96AG4 Q96AG4 LRRC59 PTHR45752:SF4 LEUCINE-RICH REPEAT-CONTAINING LEUCINE-RICH REPEAT-CONTAINING PROTEIN 59 signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 scaffold/adaptor protein#PC00226 HUMAN|HGNC=2088|UniProtKB=O76031 O76031 CLPX PTHR48102:SF7 ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL-RELATED ATP-DEPENDENT CLPX-LIKE CHAPERONE, MITOCHONDRIAL catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleotide binding#GO:0000166;anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167;hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;hydrolase activity, acting on acid anhydrides#GO:0016817;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;ATP binding#GO:0005524;nucleoside phosphate binding#GO:1901265;ATP-dependent activity#GO:0140657 protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;primary metabolic process#GO:0044238;catabolic process#GO:0009056 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229 protease#PC00190 HUMAN|HGNC=33809|UniProtKB=Q6UXQ4 Q6UXQ4 C2orf66 PTHR47620:SF1 CHROMOSOME 2 OPEN READING FRAME 66 GENE, 34066-RELATED HUMAN|HGNC=20074|UniProtKB=Q504Q3 Q504Q3 PAN2 PTHR15728:SF0 DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2 PAN2-PAN3 DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2 3'-5'-RNA exonuclease activity#GO:0000175;exonuclease activity#GO:0004527;nuclease activity#GO:0004518;hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on RNA#GO:0140098;3'-5' exonuclease activity#GO:0008408;RNA nuclease activity#GO:0004540 regulation of RNA stability#GO:0043487;regulation of RNA metabolic process#GO:0051252;positive regulation of mRNA catabolic process#GO:0061014;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;nuclear-transcribed mRNA poly(A) tail shortening#GO:0000289;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;regulation of biosynthetic process#GO:0009889;positive regulation of catabolic process#GO:0009896;nuclear-transcribed mRNA catabolic process#GO:0000956;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;macromolecule metabolic process#GO:0043170;nucleic acid catabolic process#GO:0141188;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;nucleobase-containing compound catabolic process#GO:0034655;regulation of primary metabolic process#GO:0080090;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;regulation of nucleobase-containing compound metabolic process#GO:0019219;RNA catabolic process#GO:0006401;regulation of biological quality#GO:0065008;RNA metabolic process#GO:0016070;positive regulation of metabolic process#GO:0009893;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;regulation of mRNA stability#GO:0043488;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;macromolecule catabolic process#GO:0009057;mRNA destabilization#GO:0061157;positive regulation of mRNA metabolic process#GO:1903313;metabolic process#GO:0008152;regulation of mRNA metabolic process#GO:1903311;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;RNA destabilization#GO:0050779;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;positive regulation of macromolecule metabolic process#GO:0010604 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;P-body#GO:0000932;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;protein-containing complex#GO:0032991;organelle#GO:0043226;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232 exoribonuclease#PC00099 HUMAN|HGNC=25681|UniProtKB=Q3KP44 Q3KP44 ANKRD55 PTHR24123:SF85 ANKYRIN REPEAT-CONTAINING ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 55 epithelial cell differentiation#GO:0030855;tissue development#GO:0009888;multicellular organismal process#GO:0032501;epithelium development#GO:0060429;cell differentiation#GO:0030154;cell development#GO:0048468;pancreas development#GO:0031016;cellular process#GO:0009987;anatomical structure development#GO:0048856;cellular developmental process#GO:0048869;animal organ development#GO:0048513;multicellular organism development#GO:0007275;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502 scaffold/adaptor protein#PC00226 HUMAN|HGNC=15909|UniProtKB=Q9HCD5 Q9HCD5 NCOA5 PTHR23295:SF3 NUCLEAR RECEPTOR COACTIVATOR 5-RELATED NUCLEAR RECEPTOR COACTIVATOR 5 regulation of cell communication#GO:0010646;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cellular process#GO:0050794;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;regulation of biological process#GO:0050789 organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 transcription cofactor#PC00217 HUMAN|HGNC=12657|UniProtKB=P15498 P15498 VAV1 PTHR45818:SF2 PROTEIN VAV PROTO-ONCOGENE VAV guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589 positive regulation of cellular process#GO:0048522;cell migration#GO:0016477;positive regulation of response to stimulus#GO:0048584;immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;small GTPase-mediated signal transduction#GO:0007264;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;regulation of immune system process#GO:0002682;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;cell motility#GO:0048870;regulation of cell communication#GO:0010646;regulation of immune response#GO:0050776;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051896;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;intracellular signaling cassette#GO:0141124;cell surface receptor signaling pathway#GO:0007166;immune response-regulating signaling pathway#GO:0002764;regulation of biological process#GO:0050789;positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051897;response to stimulus#GO:0050896;signaling#GO:0023052;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 B cell activation#P00010>vav#P00368;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>GEF#P00875;T cell activation#P00053>vav#P01295;PDGF signaling pathway#P00047>Vav#P01169 HUMAN|HGNC=22931|UniProtKB=Q9P2N7 Q9P2N7 KLHL13 PTHR45632:SF7 LD33804P KELCH-LIKE PROTEIN 13 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;enzyme-substrate adaptor activity#GO:0140767;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 protein metabolic process#GO:0019538;regulation of cytokinesis#GO:0032465;regulation of cell division#GO:0051302;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of cell cycle#GO:0051726;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;modification-dependent protein catabolic process#GO:0019941;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;proteasomal protein catabolic process#GO:0010498;biological regulation#GO:0065007;regulation of cell cycle process#GO:0010564;cellular process#GO:0009987 cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535;Cul3-RING ubiquitin ligase complex#GO:0031463;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;transferase complex#GO:1990234 scaffold/adaptor protein#PC00226 HUMAN|HGNC=15523|UniProtKB=Q9Y2W7 Q9Y2W7 KCNIP3 PTHR23055:SF165 CALCIUM BINDING PROTEINS CALSENILIN sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;metal ion binding#GO:0046872;DNA-binding transcription repressor activity#GO:0001217;transcription regulator activity#GO:0140110;calcium ion binding#GO:0005509;potassium channel regulator activity#GO:0015459;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;molecular function regulator activity#GO:0098772;sequence-specific double-stranded DNA binding#GO:1990837;ion channel regulator activity#GO:0099106;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;channel regulator activity#GO:0016247;cation binding#GO:0043169;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transporter regulator activity#GO:0141108;transcription cis-regulatory region binding#GO:0000976;small molecule binding#GO:0036094;nucleic acid binding#GO:0003676;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;ion binding#GO:0043167 negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of transport#GO:0051049;regulation of localization#GO:0032879;regulation of monoatomic ion transmembrane transport#GO:0034765;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;regulation of monoatomic cation transmembrane transport#GO:1904062;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;regulation of monoatomic ion transport#GO:0043269;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of transmembrane transport#GO:0034762;regulation of metal ion transport#GO:0010959;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 transporter complex#GO:1990351;cation channel complex#GO:0034703;voltage-gated potassium channel complex#GO:0008076;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;cell periphery#GO:0071944;nucleus#GO:0005634;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;transmembrane transporter complex#GO:1902495;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796 calmodulin-related#PC00061 HUMAN|HGNC=38688|UniProtKB=P0CJ86 P0CJ86 DUX4L3 PTHR46123:SF3 MIX-TYPE HOMEOBOX GENE 1-RELATED DOUBLE HOMEOBOX PROTEIN 1-RELATED transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=8983|UniProtKB=P42356 P42356 PI4KA PTHR10048:SF15 PHOSPHATIDYLINOSITOL KINASE PHOSPHATIDYLINOSITOL 4-KINASE ALPHA lipid kinase activity#GO:0001727;phosphotransferase activity, alcohol group as acceptor#GO:0016773;phosphatidylinositol kinase activity#GO:0052742;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740 metabolic process#GO:0008152;lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;signal transduction#GO:0007165;lipid biosynthetic process#GO:0008610;glycerophospholipid metabolic process#GO:0006650;biosynthetic process#GO:0009058;biological regulation#GO:0065007;phosphatidylinositol phosphate biosynthetic process#GO:0046854;organophosphate biosynthetic process#GO:0090407;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;phospholipid biosynthetic process#GO:0008654;regulation of cellular process#GO:0050794;glycerolipid metabolic process#GO:0046486;response to stimulus#GO:0050896;signaling#GO:0023052;phospholipid metabolic process#GO:0006644 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 kinase#PC00137 HUMAN|HGNC=8596|UniProtKB=P19021 P19021 PAM PTHR10680:SF14 PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;monooxygenase activity#GO:0004497;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 oxygenase#PC00177;metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 Vasopressin synthesis#P04395>Amidating Enzyme#P04599 HUMAN|HGNC=32576|UniProtKB=A2VCK2 A2VCK2 DCDC2B PTHR23004:SF10 DOUBLECORTIN DOMAIN CONTAINING 2 DOUBLECORTIN DOMAIN-CONTAINING PROTEIN 2B microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513 HUMAN|HGNC=9816|UniProtKB=Q92878 Q92878 RAD50 PTHR18867:SF12 RAD50 DNA REPAIR PROTEIN RAD50 binding#GO:0005488;nucleic acid binding#GO:0003676;single-stranded DNA binding#GO:0003697;DNA binding#GO:0003677;telomeric repeat DNA binding#GO:0042162;sequence-specific DNA binding#GO:0043565;double-stranded DNA binding#GO:0003690 response to stimulus#GO:0050896;cell cycle process#GO:0022402;cellular component organization#GO:0016043;meiotic cell cycle process#GO:1903046;nucleic acid biosynthetic process#GO:0141187;cellular response to stress#GO:0033554;telomere maintenance via telomere lengthening#GO:0010833;telomere maintenance via telomerase#GO:0007004;DNA biosynthetic process#GO:0071897;cellular process#GO:0009987;organelle organization#GO:0006996;response to stress#GO:0006950;double-strand break repair#GO:0006302;cellular component organization or biogenesis#GO:0071840;DNA recombination#GO:0006310;chromosome organization involved in meiotic cell cycle#GO:0070192;metabolic process#GO:0008152;meiotic cell cycle#GO:0051321;DNA metabolic process#GO:0006259;nucleobase-containing compound biosynthetic process#GO:0034654;reproductive process#GO:0022414;cellular response to stimulus#GO:0051716;cell cycle#GO:0007049;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;telomere organization#GO:0032200;sexual reproduction#GO:0019953;mitotic recombination#GO:0006312;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;macromolecule biosynthetic process#GO:0009059;telomere maintenance#GO:0000723;chromosome organization#GO:0051276;macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;RNA-templated DNA biosynthetic process#GO:0006278;DNA repair#GO:0006281 condensed nuclear chromosome#GO:0000794;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;condensed chromosome#GO:0000793;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;chromosome#GO:0005694 HUMAN|HGNC=14088|UniProtKB=Q9UGC6 Q9UGC6 RGS17 PTHR10845:SF196 REGULATOR OF G PROTEIN SIGNALING REGULATOR OF G PROTEIN SIGNALING 17 molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme activator activity#GO:0008047 negative regulation of signal transduction#GO:0009968;regulation of cell communication#GO:0010646;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of response to stimulus#GO:0048585;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of G protein-coupled receptor signaling pathway#GO:0045744;negative regulation of biological process#GO:0048519;negative regulation of cell communication#GO:0010648;regulation of signaling#GO:0023051;regulation of G protein-coupled receptor signaling pathway#GO:0008277;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;negative regulation of signaling#GO:0023057 cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;plasma membrane#GO:0005886;cytoplasmic side of plasma membrane#GO:0009898;membrane#GO:0016020;cell periphery#GO:0071944;cytoplasmic side of membrane#GO:0098562 GTPase-activating protein#PC00257 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>RGS#P00731;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>RGS#P00704;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>RGS#P00833 HUMAN|HGNC=30873|UniProtKB=Q96H22 Q96H22 CENPN PTHR46790:SF1 CENTROMERE PROTEIN N CENTROMERE PROTEIN N nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 HUMAN|HGNC=24168|UniProtKB=Q6WN34 Q6WN34 CHRDL2 PTHR46303:SF3 VWFC DOMAIN-CONTAINING PROTEIN CHORDIN-LIKE PROTEIN 2 protein binding#GO:0005515;cytokine binding#GO:0019955;binding#GO:0005488 regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of biological process#GO:0050789;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092;negative regulation of biological process#GO:0048519;negative regulation of cell communication#GO:0010648;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;negative regulation of signal transduction#GO:0009968;biological regulation#GO:0065007;regulation of cellular response to growth factor stimulus#GO:0090287;regulation of signal transduction#GO:0009966;negative regulation of response to stimulus#GO:0048585;cellular process#GO:0009987;regulation of BMP signaling pathway#GO:0030510;negative regulation of BMP signaling pathway#GO:0030514;cellular developmental process#GO:0048869;regulation of response to stimulus#GO:0048583;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=20|UniProtKB=P49588 P49588 AARS1 PTHR11777:SF36 ALANYL-TRNA SYNTHETASE ALANINE--TRNA LIGASE, CYTOPLASMIC catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on ester bonds#GO:0016788;ligase activity#GO:0016874;catalytic activity#GO:0003824;deacylase activity#GO:0160215;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on a tRNA#GO:0140101;hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689 protein metabolic process#GO:0019538;RNA metabolic process#GO:0016070;translation#GO:0006412;protein biosynthetic process#GO:0160307;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;amino acid activation#GO:0043038;macromolecule metabolic process#GO:0043170;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;amino acid metabolic process#GO:0006520;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;tRNA aminoacylation for protein translation#GO:0006418;tRNA aminoacylation#GO:0043039 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 aminoacyl-tRNA synthetase#PC00047 HUMAN|HGNC=1778|UniProtKB=P50613 P50613 CDK7 PTHR24056:SF375 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE 7 catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;cyclin-dependent protein kinase activity#GO:0097472;protein serine/threonine kinase activity#GO:0004674;cyclin-dependent protein serine/threonine kinase activity#GO:0004693 regulation of biological process#GO:0050789;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of cell cycle#GO:0051726;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;regulation of cellular process#GO:0050794;DNA-templated transcription initiation#GO:0006352;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;transcription initiation at RNA polymerase II promoter#GO:0006367;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;biological regulation#GO:0065007;gene expression#GO:0010467;transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170 nucleus#GO:0005634;RNA polymerase complex#GO:0030880;RNA polymerase II transcription regulator complex#GO:0090575;membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;protein-containing complex#GO:0032991;transferase complex#GO:1990234;protein kinase complex#GO:1902911;intracellular protein-containing complex#GO:0140535;transcription regulator complex#GO:0005667;nuclear protein-containing complex#GO:0140513;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transcription factor TFIIH holo complex#GO:0005675;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;RNA polymerase II, holoenzyme#GO:0016591 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=23247|UniProtKB=Q4LDG9 Q4LDG9 DNAL1 PTHR15454:SF33 NISCHARIN RELATED DYNEIN AXONEMAL LIGHT CHAIN 1 protein binding#GO:0005515;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;binding#GO:0005488 organelle assembly#GO:0070925;axonemal dynein complex assembly#GO:0070286;microtubule bundle formation#GO:0001578;microtubule cytoskeleton organization#GO:0000226;cilium organization#GO:0044782;axoneme assembly#GO:0035082;cellular component organization#GO:0016043;cilium assembly#GO:0060271;protein-containing complex assembly#GO:0065003;cell projection organization#GO:0030030;plasma membrane bounded cell projection assembly#GO:0120031;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;microtubule-based process#GO:0007017;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;outer dynein arm assembly#GO:0036158;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton organization#GO:0007010 scaffold/adaptor protein#PC00226 HUMAN|HGNC=10624|UniProtKB=O15444 O15444 CCL25 PTHR12015:SF70 SMALL INDUCIBLE CYTOKINE A C-C MOTIF CHEMOKINE 25 molecular function activator activity#GO:0140677;protein binding#GO:0005515;chemokine receptor binding#GO:0042379;cytokine activity#GO:0005125;signaling receptor binding#GO:0005102;binding#GO:0005488;cytokine receptor binding#GO:0005126;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;chemokine activity#GO:0008009;G protein-coupled receptor binding#GO:0001664;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545 cellular response to stimulus#GO:0051716;response to external biotic stimulus#GO:0043207;locomotion#GO:0040011;cellular response to chemokine#GO:1990869;regulation of cellular process#GO:0050794;cell motility#GO:0048870;inflammatory response#GO:0006954;chemotaxis#GO:0006935;cytokine-mediated signaling pathway#GO:0019221;cell chemotaxis#GO:0060326;cell communication#GO:0007154;regulation of cell motility#GO:2000145;chemokine-mediated signaling pathway#GO:0070098;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;positive regulation of cellular process#GO:0048522;immune response#GO:0006955;positive regulation of cell migration#GO:0030335;biological regulation#GO:0065007;response to other organism#GO:0051707;regulation of locomotion#GO:0040012;cell migration#GO:0016477;regulation of cell migration#GO:0030334;leukocyte migration#GO:0050900;positive regulation of locomotion#GO:0040017;response to external stimulus#GO:0009605;myeloid leukocyte migration#GO:0097529;defense response#GO:0006952;leukocyte chemotaxis#GO:0030595;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;positive regulation of cell motility#GO:2000147;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;granulocyte chemotaxis#GO:0071621;response to stimulus#GO:0050896;immune system process#GO:0002376;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;response to peptide#GO:1901652;positive regulation of biological process#GO:0048518;defense response to symbiont#GO:0140546;signal transduction#GO:0007165;cellular process#GO:0009987;response to biotic stimulus#GO:0009607;response to chemokine#GO:1990868;response to stress#GO:0006950;taxis#GO:0042330;response to cytokine#GO:0034097;response to chemical#GO:0042221;defense response to other organism#GO:0098542;granulocyte migration#GO:0097530;cell surface receptor signaling pathway#GO:0007166;humoral immune response#GO:0006959;antimicrobial humoral response#GO:0019730 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 cytokine#PC00083 HUMAN|HGNC=37116|UniProtKB=A6NP61 A6NP61 ZAR1L PTHR31054:SF5 ZYGOTE ARREST PROTEIN 1-LIKE ISOFORM X1 PROTEIN ZAR1-LIKE mRNA 3'-UTR binding#GO:0003730;RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729 oogenesis#GO:0048477;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of protein metabolic process#GO:0051246;negative regulation of translation#GO:0017148;negative regulation of metabolic process#GO:0009892;cellular process involved in reproduction in multicellular organism#GO:0022412;cell development#GO:0048468;cell differentiation#GO:0030154;gamete generation#GO:0007276;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of gene expression#GO:0010468;cell maturation#GO:0048469;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;developmental maturation#GO:0021700;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;multicellular organismal reproductive process#GO:0048609;anatomical structure development#GO:0048856;sexual reproduction#GO:0019953;reproductive process#GO:0022414;negative regulation of protein metabolic process#GO:0051248;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;anatomical structure maturation#GO:0071695;germ cell development#GO:0007281;developmental process involved in reproduction#GO:0003006 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=17279|UniProtKB=Q99935 Q99935 OPRPN PTHR14179:SF8 SMR1-RELATED OPIORPHIN PREPROPEPTIDE peptidase regulator activity#GO:0061134;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;enzyme inhibitor activity#GO:0004857;molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866 biological regulation#GO:0065007;regulation of multicellular organismal process#GO:0051239;regulation of system process#GO:0044057;regulation of biological process#GO:0050789 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease inhibitor#PC00191;protein-binding activity modulator#PC00095 HUMAN|HGNC=16511|UniProtKB=Q92599 Q92599 SEPTIN8 PTHR18884:SF54 SEPTIN SEPTIN-8 catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111 cytokinesis#GO:0000910;cytoskeleton-dependent cytokinesis#GO:0061640;localization#GO:0051179;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;cell cycle#GO:0007049;cell division#GO:0051301;cellular process#GO:0009987;cell cycle process#GO:0022402 intracellular membraneless organelle#GO:0043232;cell division site#GO:0032153;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cell cortex#GO:0005938;cell periphery#GO:0071944;microtubule cytoskeleton#GO:0015630;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 cytoskeletal protein#PC00085 HUMAN|HGNC=22234|UniProtKB=Q8WZ19 Q8WZ19 KCTD13 PTHR11145:SF18 BTB/POZ DOMAIN-CONTAINING ADAPTER FOR CUL3-MEDIATED RHOA DEGRADATION PROTEIN FAMILY MEMBER BTB_POZ DOMAIN-CONTAINING ADAPTER FOR CUL3-MEDIATED RHOA DEGRADATION PROTEIN 1 protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;protein modification process#GO:0036211;regulation of cell communication#GO:0010646;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;post-translational protein modification#GO:0043687;negative regulation of response to stimulus#GO:0048585;protein catabolic process#GO:0030163;regulation of signaling#GO:0023051;modification-dependent macromolecule catabolic process#GO:0043632;protein modification by small protein conjugation or removal#GO:0070647;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;protein modification by small protein conjugation#GO:0032446;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of Rho protein signal transduction#GO:0035023;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;regulation of small GTPase mediated signal transduction#GO:0051056;cellular process#GO:0009987;protein ubiquitination#GO:0016567;proteasomal protein catabolic process#GO:0010498;negative regulation of signal transduction#GO:0009968 intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;Cul3-RING ubiquitin ligase complex#GO:0031463;catalytic complex#GO:1902494;transferase complex#GO:1990234 scaffold/adaptor protein#PC00226 HUMAN|HGNC=24154|UniProtKB=Q8N8U9 Q8N8U9 BMPER PTHR11339:SF272 EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED BMP-BINDING ENDOTHELIAL REGULATOR PROTEIN structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 animal gross anatomical part developmental process#GO:0160108;anatomical structure development#GO:0048856;system development#GO:0048731;regulation of angiogenesis#GO:0045765;regulation of biological process#GO:0050789;blood vessel development#GO:0001568;regulation of multicellular organismal development#GO:2000026;circulatory system development#GO:0072359;regulation of developmental process#GO:0050793;regulation of vasculature development#GO:1901342;developmental process#GO:0032502;multicellular organism development#GO:0007275;regulation of anatomical structure morphogenesis#GO:0022603;vasculature development#GO:0001944;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;regulation of multicellular organismal process#GO:0051239 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 extracellular matrix protein#PC00102 HUMAN|HGNC=23069|UniProtKB=O75865 O75865 TRAPPC6A PTHR12817:SF2 TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 6B TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 6A intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;transport#GO:0006810;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192 Golgi apparatus subcompartment#GO:0098791;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasm#GO:0005737;TRAPP complex#GO:0030008;trans-Golgi network#GO:0005802;Golgi apparatus#GO:0005794;intracellular protein-containing complex#GO:0140535;vesicle tethering complex#GO:0099023;cis-Golgi network#GO:0005801;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984 HUMAN|HGNC=16943|UniProtKB=Q9UKI2 Q9UKI2 CDC42EP3 PTHR15344:SF3 CDC42 EFFECTOR PROTEIN BORG CDC42 EFFECTOR PROTEIN 3 small GTPase binding#GO:0031267;protein binding#GO:0005515;binding#GO:0005488;enzyme binding#GO:0019899 regulation of actin filament-based process#GO:0032970;regulation of cell projection organization#GO:0031344;regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of actin filament organization#GO:0110053;positive regulation of cellular process#GO:0048522;positive regulation of protein polymerization#GO:0032273;regulation of actin filament polymerization#GO:0030833;biological regulation#GO:0065007;regulation of actin polymerization or depolymerization#GO:0008064;small GTPase-mediated signal transduction#GO:0007264;positive regulation of cell projection organization#GO:0031346;cell communication#GO:0007154;regulation of cell projection assembly#GO:0060491;intracellular signal transduction#GO:0035556;cellular response to stimulus#GO:0051716;regulation of supramolecular fiber organization#GO:1902903;regulation of cellular process#GO:0050794;regulation of protein polymerization#GO:0032271;regulation of cytoskeleton organization#GO:0051493;regulation of developmental process#GO:0050793;regulation of anatomical structure size#GO:0090066;regulation of anatomical structure morphogenesis#GO:0022603;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;positive regulation of cellular component biogenesis#GO:0044089;regulation of actin cytoskeleton organization#GO:0032956;intracellular signaling cassette#GO:0141124;positive regulation of cellular component organization#GO:0051130;regulation of actin filament length#GO:0030832;positive regulation of organelle organization#GO:0010638;Rho protein signal transduction#GO:0007266;regulation of biological quality#GO:0065008;cellular component organization#GO:0016043;regulation of protein-containing complex assembly#GO:0043254;regulation of organelle organization#GO:0033043;regulation of cell shape#GO:0008360;regulation of cellular component size#GO:0032535;regulation of biological process#GO:0050789;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;regulation of plasma membrane bounded cell projection assembly#GO:0120032;regulation of cellular component biogenesis#GO:0044087;signaling#GO:0023052 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;cell periphery#GO:0071944;membrane#GO:0016020;cytoplasm#GO:0005737;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226 scaffold/adaptor protein#PC00226 HUMAN|HGNC=13166|UniProtKB=Q05481 Q05481 ZNF91 PTHR24376:SF210 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 721-RELATED C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=25503|UniProtKB=Q9NW64 Q9NW64 RBM22 PTHR14089:SF6 PRE-MRNA-SPLICING FACTOR RBM22 PRE-MRNA-SPLICING FACTOR RBM22 binding#GO:0005488;pre-mRNA binding#GO:0036002;nucleic acid binding#GO:0003676;snRNA binding#GO:0017069;RNA binding#GO:0003723 ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;catalytic step 2 spliceosome#GO:0071013;nuclear protein-containing complex#GO:0140513;Prp19 complex#GO:0000974;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;spliceosomal complex#GO:0005681;nucleus#GO:0005634;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;U2-type spliceosomal complex#GO:0005684 RNA processing factor#PC00147;RNA splicing factor#PC00148;RNA metabolism protein#PC00031 HUMAN|HGNC=4706|UniProtKB=P13807 P13807 GYS1 PTHR10176:SF2 GLYCOGEN SYNTHASE GLYCOGEN [STARCH] SYNTHASE, MUSCLE glucosyltransferase activity#GO:0046527;glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194;UDP-glucosyltransferase activity#GO:0035251;hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740 biosynthetic process#GO:0009058;carbohydrate biosynthetic process#GO:0016051;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;energy derivation by oxidation of organic compounds#GO:0015980;generation of precursor metabolites and energy#GO:0006091;glycogen biosynthetic process#GO:0005978;metabolic process#GO:0008152;carbohydrate metabolic process#GO:0005975;polysaccharide metabolic process#GO:0005976;glycogen metabolic process#GO:0005977;glucan metabolic process#GO:0044042;primary metabolic process#GO:0044238;glucan biosynthetic process#GO:0009250;polysaccharide biosynthetic process#GO:0000271;energy reserve metabolic process#GO:0006112 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Glycogen synthase D#P00709 HUMAN|HGNC=23822|UniProtKB=Q86YR6 Q86YR6 POTED PTHR24147:SF66 ANKYRIN REPEAT DOMAIN 36-RELATED CCDC144C-LIKE COILED-COIL DOMAIN-CONTAINING PROTEIN-RELATED HUMAN|HGNC=8346|UniProtKB=A6NKK0 A6NKK0 OR5H1 PTHR26452:SF747 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5H1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 system process#GO:0003008;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;nervous system process#GO:0050877;sensory perception#GO:0007600;sensory perception of chemical stimulus#GO:0007606 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=8683|UniProtKB=Q9Y5F1 Q9Y5F1 PCDHB12 PTHR24028:SF334 CADHERIN-87A PROTOCADHERIN BETA-12 cellular process#GO:0009987;cell adhesion#GO:0007155 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 cadherin#PC00057;cell adhesion molecule#PC00069 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HUMAN|HGNC=13724|UniProtKB=P61421 P61421 ATP6V0D1 PTHR11028:SF3 VACUOLAR ATP SYNTHASE SUBUNIT AC39 V-TYPE PROTON ATPASE SUBUNIT D 1 monoatomic cation transmembrane transporter activity#GO:0008324;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626;monoatomic ion transmembrane transporter activity#GO:0015075;primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804;proton transmembrane transporter activity#GO:0015078;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 intracellular monoatomic ion homeostasis#GO:0006873;homeostatic process#GO:0042592;regulation of intracellular pH#GO:0051453;regulation of pH#GO:0006885;regulation of biological quality#GO:0065008;cellular localization#GO:0051641;localization#GO:0051179;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;monoatomic ion homeostasis#GO:0050801;biological regulation#GO:0065007;transport#GO:0006810;intracellular monoatomic cation homeostasis#GO:0030003;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;vacuolar transport#GO:0007034;intracellular transport#GO:0046907;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;vacuolar acidification#GO:0007035;establishment of localization#GO:0051234 vacuole#GO:0005773;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;lysosomal membrane#GO:0005765;bounding membrane of organelle#GO:0098588;lytic vacuole#GO:0000323;transporter complex#GO:1990351;proton-transporting two-sector ATPase complex#GO:0016469;organelle#GO:0043226;cellular anatomical structure#GO:0110165;lysosome#GO:0005764;lytic vacuole membrane#GO:0098852;intracellular vesicle#GO:0097708;early endosome#GO:0005769;ATPase dependent transmembrane transport complex#GO:0098533;intracellular organelle#GO:0043229;ATPase complex#GO:1904949;endosome#GO:0005768;plasma membrane#GO:0005886;endomembrane system#GO:0012505;cell periphery#GO:0071944;membrane#GO:0016020;proton-transporting V-type ATPase complex#GO:0033176;organelle membrane#GO:0031090;vacuolar membrane#GO:0005774;intracellular membrane-bounded organelle#GO:0043231;vesicle#GO:0031982;plasma membrane protein complex#GO:0098797;cation-transporting ATPase complex#GO:0090533;membrane protein complex#GO:0098796;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;transmembrane transporter complex#GO:1902495;vacuolar proton-transporting V-type ATPase complex#GO:0016471;catalytic complex#GO:1902494 ATP synthase#PC00002 HUMAN|HGNC=14118|UniProtKB=Q9BZJ3 Q9BZJ3 TPSD1 PTHR24256:SF521 TRYPTASE-RELATED TRYPTASE DELTA serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;serine-type peptidase activity#GO:0008236 cellular process#GO:0009987;primary metabolic process#GO:0044238;proteolysis#GO:0006508;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 serine protease#PC00203 HUMAN|HGNC=6367|UniProtKB=Q92876 Q92876 KLK6 PTHR24271:SF19 KALLIKREIN-RELATED KALLIKREIN-6 peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;serine-type peptidase activity#GO:0008236 protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152 intracellular organelle#GO:0043229;extracellular region#GO:0005576;membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular vesicle#GO:0097708;secretory vesicle#GO:0099503;vesicle#GO:0031982;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 serine protease#PC00203 HUMAN|HGNC=7623|UniProtKB=Q9UL68 Q9UL68 MYT1L PTHR10816:SF11 MYELIN TRANSCRIPTION FACTOR 1-RELATED MYELIN TRANSCRIPTION FACTOR 1-LIKE PROTEIN sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=868|UniProtKB=Q15904 Q15904 ATP6AP1 PTHR12471:SF2 VACUOLAR ATP SYNTHASE SUBUNIT S1 V-TYPE PROTON ATPASE SUBUNIT S1 monoatomic ion homeostasis#GO:0050801;intracellular monoatomic ion homeostasis#GO:0006873;biological regulation#GO:0065007;homeostatic process#GO:0042592;regulation of pH#GO:0006885;chemical homeostasis#GO:0048878;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;regulation of intracellular pH#GO:0051453;cellular homeostasis#GO:0019725;regulation of biological quality#GO:0065008;intracellular chemical homeostasis#GO:0055082 catalytic complex#GO:1902494;ATPase complex#GO:1904949;proton-transporting two-sector ATPase complex#GO:0016469;proton-transporting V-type ATPase complex#GO:0033176;ATPase dependent transmembrane transport complex#GO:0098533;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;cation-transporting ATPase complex#GO:0090533;membrane protein complex#GO:0098796;membrane#GO:0016020;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 primary active transporter#PC00068;ATP synthase#PC00002 HUMAN|HGNC=34228|UniProtKB=I1YAP6 I1YAP6 TRIM77 PTHR24103:SF567 E3 UBIQUITIN-PROTEIN LIGASE TRIM TRIPARTITE MOTIF-CONTAINING PROTEIN 77 catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659 immune system process#GO:0002376;regulation of biological process#GO:0050789;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;response to external stimulus#GO:0009605;defense response#GO:0006952;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;innate immune response#GO:0045087;defense response to symbiont#GO:0140546;immune response#GO:0006955;response to biotic stimulus#GO:0009607;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;response to stress#GO:0006950;biological regulation#GO:0065007;response to other organism#GO:0051707;defense response to other organism#GO:0098542 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=14718|UniProtKB=Q8NGQ6 Q8NGQ6 OR9I1 PTHR48018:SF58 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 9I1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 signaling#GO:0023052;regulation of cellular process#GO:0050794;sensory perception of smell#GO:0007608;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cell communication#GO:0007154;nervous system process#GO:0050877;sensory perception#GO:0007600;G protein-coupled receptor signaling pathway#GO:0007186;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;cellular process#GO:0009987;signal transduction#GO:0007165;system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=4552|UniProtKB=P24298 P24298 GPT PTHR11751:SF308 ALANINE AMINOTRANSFERASE ALANINE AMINOTRANSFERASE 1 transferase#PC00220;transaminase#PC00216 HUMAN|HGNC=17295|UniProtKB=Q8N1P7 Q8N1P7 CRYBG2 PTHR11818:SF50 BETA/GAMMA CRYSTALLIN BETA_GAMMA CRYSTALLIN DOMAIN-CONTAINING PROTEIN 2 structural molecule activity#GO:0005198 sensory perception of light stimulus#GO:0050953;visual system development#GO:0150063;visual perception#GO:0007601;sensory perception#GO:0007600;nervous system process#GO:0050877;camera-type eye development#GO:0043010;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;eye development#GO:0001654;anatomical structure development#GO:0048856;sensory system development#GO:0048880;multicellular organismal process#GO:0032501;lens development in camera-type eye#GO:0002088;developmental process#GO:0032502;sensory organ development#GO:0007423;system process#GO:0003008;multicellular organism development#GO:0007275;animal organ development#GO:0048513 structural protein#PC00211 HUMAN|HGNC=8186|UniProtKB=P58170 P58170 OR1D5 PTHR48001:SF70 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 1D4-RELATED olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cell communication#GO:0007154;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=14171|UniProtKB=Q96A99 Q96A99 PTX4 PTHR19277:SF122 PENTRAXIN PENTRAXIN-4 scaffold/adaptor protein#PC00226 HUMAN|HGNC=10723|UniProtKB=Q14563 Q14563 SEMA3A PTHR11036:SF23 SEMAPHORIN SEMAPHORIN-3A signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515;molecular function activator activity#GO:0140677;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546 regulation of cellular process#GO:0050794;cell motility#GO:0048870;cellular response to stimulus#GO:0051716;anatomical structure development#GO:0048856;chemotaxis#GO:0006935;stem cell development#GO:0048864;regulation of locomotion#GO:0040012;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;positive regulation of cell migration#GO:0030335;positive regulation of cellular process#GO:0048522;axon guidance#GO:0007411;mesenchyme development#GO:0060485;neurogenesis#GO:0022008;neuron projection guidance#GO:0097485;positive regulation of locomotion#GO:0040017;neuron projection morphogenesis#GO:0048812;regulation of cell migration#GO:0030334;cell development#GO:0048468;cell morphogenesis#GO:0000902;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;neuron development#GO:0048666;axonogenesis#GO:0007409;animal gross anatomical part developmental process#GO:0160108;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;taxis#GO:0042330;neural crest cell migration#GO:0001755;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;neuron projection development#GO:0031175;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;neuron differentiation#GO:0030182;locomotion#GO:0040011;system development#GO:0048731;regulation of cell motility#GO:2000145;cell communication#GO:0007154;plasma membrane bounded cell projection organization#GO:0120036;neural crest cell development#GO:0014032;cell migration#GO:0016477;tissue development#GO:0009888;axon development#GO:0061564;stem cell differentiation#GO:0048863;response to external stimulus#GO:0009605;cellular developmental process#GO:0048869;developmental process#GO:0032502;signaling#GO:0023052;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cellular component organization#GO:0016043;motor neuron axon guidance#GO:0008045;positive regulation of cell motility#GO:2000147;generation of neurons#GO:0048699;response to chemical#GO:0042221;cell projection morphogenesis#GO:0048858;animal organ development#GO:0048513;cell surface receptor signaling pathway#GO:0007166;plasma membrane bounded cell projection morphogenesis#GO:0120039;mesenchymal cell differentiation#GO:0048762;neural crest cell differentiation#GO:0014033 extracellular region#GO:0005576;axon#GO:0030424;cell junction#GO:0030054;cell periphery#GO:0071944;neuron projection#GO:0043005;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;plasma membrane#GO:0005886;glutamatergic synapse#GO:0098978;cellular anatomical structure#GO:0110165;synapse#GO:0045202 membrane-bound signaling molecule#PC00152 Axon guidance mediated by semaphorins#P00007>Sema3A#P00337 HUMAN|HGNC=24285|UniProtKB=Q96DB5 Q96DB5 RMDN1 PTHR16056:SF16 REGULATOR OF MICROTUBULE DYNAMICS PROTEIN REGULATOR OF MICROTUBULE DYNAMICS PROTEIN 1 tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;microtubule binding#GO:0008017;protein binding#GO:0005515 mitochondrion#GO:0005739;spindle pole#GO:0000922;mitotic spindle#GO:0072686;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;supramolecular fiber#GO:0099512;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;spindle microtubule#GO:0005876;microtubule cytoskeleton#GO:0015630;mitotic spindle pole#GO:0097431;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;spindle#GO:0005819;cytoskeleton#GO:0005856;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228 microtubule or microtubule-binding cytoskeletal protein#PC00157;non-motor microtubule binding protein#PC00166;cytoskeletal protein#PC00085 HUMAN|HGNC=17301|UniProtKB=Q9UHG2 Q9UHG2 PCSK1N PTHR15531:SF0 PROSAAS PROSAAS enzyme inhibitor activity#GO:0004857;endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;peptidase regulator activity#GO:0061134;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;serine-type endopeptidase inhibitor activity#GO:0004867 proteolysis#GO:0006508;protein metabolic process#GO:0019538;signaling receptor ligand precursor processing#GO:0140448;regulation of biological quality#GO:0065008;primary metabolic process#GO:0044238;regulation of hormone levels#GO:0010817;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein processing#GO:0016485;peptide hormone processing#GO:0016486;gene expression#GO:0010467;protein maturation#GO:0051604;hormone metabolic process#GO:0042445;biological regulation#GO:0065007;biosynthetic process#GO:0009058 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HUMAN|HGNC=25185|UniProtKB=Q6NXT1 Q6NXT1 ANKRD54 PTHR24197:SF51 ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 61 ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 54 enzyme regulator activity#GO:0030234;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;protein kinase regulator activity#GO:0019887 regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;regulation of intracellular signal transduction#GO:1902531;regulation of biological process#GO:0050789;regulation of cell communication#GO:0010646;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cellular process#GO:0050794 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=24536|UniProtKB=Q6UWI2 Q6UWI2 PARM1 PTHR35453:SF1 PROSTATE ANDROGEN-REGULATED MUCIN-LIKE PROTEIN 1 PROSTATE ANDROGEN-REGULATED MUCIN-LIKE PROTEIN 1 intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;early endosome#GO:0005769;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;Golgi apparatus#GO:0005794;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;late endosome#GO:0005770;endomembrane system#GO:0012505 HUMAN|HGNC=29298|UniProtKB=O94986 O94986 CEP152 PTHR10337:SF6 SHC TRANSFORMING PROTEIN CENTROSOMAL PROTEIN OF 152 KDA protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 cellular component organization or biogenesis#GO:0071840;centrosome duplication#GO:0051298;microtubule-based process#GO:0007017;microtubule organizing center organization#GO:0031023;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;microtubule cytoskeleton organization#GO:0000226;organelle assembly#GO:0070925;centriole replication#GO:0007099;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;cell cycle#GO:0007049;cell cycle process#GO:0022402;centrosome cycle#GO:0007098 microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;microtubule organizing center#GO:0005815;centrosome#GO:0005813;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 scaffold/adaptor protein#PC00226 HUMAN|HGNC=26002|UniProtKB=Q86V15 Q86V15 CASZ1 PTHR12451:SF0 TRANSCRIPTION FACTOR CASTOR PROTEIN MING -RELATED ZINC FINGER PROTEIN CASTOR HOMOLOG 1 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of cell differentiation#GO:0045595;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;regulation of neuron differentiation#GO:0045664;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA metabolic process#GO:0051252;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of developmental process#GO:0050793;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;zinc finger transcription factor#PC00244 HUMAN|HGNC=2174|UniProtKB=Q8IWV2 Q8IWV2 CNTN4 PTHR10075:SF63 BASIGIN RELATED CONTACTIN-4 cell adhesion molecule#PC00069 HUMAN|HGNC=19088|UniProtKB=Q9NR48 Q9NR48 ASH1L PTHR46147:SF1 HISTONE-LYSINE N-METHYLTRANSFERASE ASH1 HISTONE-LYSINE N-METHYLTRANSFERASE ASH1L catalytic activity, acting on a protein#GO:0140096;protein methyltransferase activity#GO:0008276;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring one-carbon groups#GO:0016741;histone H3K4 methyltransferase activity#GO:0042800;lysine N-methyltransferase activity#GO:0016278;histone modifying activity#GO:0140993;histone H3 methyltransferase activity#GO:0140938;histone methyltransferase activity#GO:0042054;protein-lysine N-methyltransferase activity#GO:0016279;N-methyltransferase activity#GO:0008170;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 histone modifying enzyme#PC00261;chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=4244|UniProtKB=O00451 O00451 GFRA2 PTHR10269:SF4 GDNF RECEPTOR ALPHA GDNF FAMILY RECEPTOR ALPHA-2 signaling receptor activity#GO:0038023;immune receptor activity#GO:0140375;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;cytokine receptor activity#GO:0004896 animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502;multicellular organism development#GO:0007275;anatomical structure development#GO:0048856;multicellular organismal process#GO:0032501;system development#GO:0048731;nervous system development#GO:0007399 side of membrane#GO:0098552;signaling receptor complex#GO:0043235;external side of plasma membrane#GO:0009897;cell surface#GO:0009986;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=10936|UniProtKB=Q16572 Q16572 SLC18A3 PTHR23506:SF13 GH10249P VESICULAR ACETYLCHOLINE TRANSPORTER monoatomic cation transmembrane transporter activity#GO:0008324;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;monoamine transmembrane transporter activity#GO:0008504;transporter activity#GO:0005215;proton transmembrane transporter activity#GO:0015078;antiporter activity#GO:0015297;active transmembrane transporter activity#GO:0022804;monoatomic ion transmembrane transporter activity#GO:0015075 biological regulation#GO:0065007;cell-cell signaling#GO:0007267;signaling#GO:0023052;anterograde trans-synaptic signaling#GO:0098916;cellular process#GO:0009987;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;synaptic signaling#GO:0099536;cell communication#GO:0007154;trans-synaptic signaling#GO:0099537 intracellular organelle#GO:0043229;coated membrane#GO:0048475;coated vesicle#GO:0030135;endocytic vesicle#GO:0030139;intracellular vesicle#GO:0097708;clathrin-coated pit#GO:0005905;clathrin coat#GO:0030118;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;coated vesicle membrane#GO:0030662;cell projection#GO:0042995;Golgi-associated vesicle membrane#GO:0030660;clathrin vesicle coat#GO:0030125;clathrin-coated endocytic vesicle#GO:0045334;clathrin-coated vesicle membrane#GO:0030665;cell junction#GO:0030054;bounding membrane of organelle#GO:0098588;AP-type membrane coat adaptor complex#GO:0030119;neuron projection#GO:0043005;presynapse#GO:0098793;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;vesicle coat#GO:0030120;trans-Golgi network transport vesicle#GO:0030140;AP-1 adaptor complex#GO:0030121;axon#GO:0030424;membrane coat#GO:0030117;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;vesicle#GO:0031982;terminal bouton#GO:0043195;distal axon#GO:0150034;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;neuron projection terminus#GO:0044306;clathrin-coated vesicle#GO:0030136;trans-Golgi network transport vesicle membrane#GO:0012510;Golgi-associated vesicle#GO:0005798;Golgi apparatus#GO:0005794;organelle membrane#GO:0031090;axon terminus#GO:0043679;membrane#GO:0016020;vesicle membrane#GO:0012506;cell periphery#GO:0071944;endomembrane system#GO:0012505;transport vesicle membrane#GO:0030658;transport vesicle#GO:0030133;plasma membrane#GO:0005886 transporter#PC00227;secondary carrier transporter#PC00258 Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>VAChT#P01065;Nicotinic acetylcholine receptor signaling pathway#P00044>VAChT#P01089;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>VAChT#P01078 HUMAN|HGNC=23717|UniProtKB=Q96CX3 Q96CX3 ZNF501 PTHR24404:SF135 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 501 cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218 HUMAN|HGNC=2352|UniProtKB=Q03060 Q03060 CREM PTHR45879:SF4 CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN B CAMP-RESPONSIVE ELEMENT MODULATOR sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;regulation of DNA-templated transcription#GO:0006355;intracellular signal transduction#GO:0035556;regulation of RNA metabolic process#GO:0051252 intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229 basic leucine zipper transcription factor#PC00056;DNA-binding transcription factor#PC00218 Apoptosis signaling pathway#P00006>ATF#P00302;Transcription regulation by bZIP transcription factor#P00055>CREB#P01383;CCKR signaling map#P06959>ICER#P07027;Enkephalin release#P05913>CREB#P05971;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>CPB#P00702 HUMAN|HGNC=25105|UniProtKB=Q9H930 Q9H930 SP140L PTHR46386:SF14 NUCLEAR BODY PROTEIN SP140 NUCLEAR BODY PROTEIN SP140-LIKE PROTEIN DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=6838|UniProtKB=Q9H492 Q9H492 MAP1LC3A PTHR10969:SF14 MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED MICROTUBULE-ASSOCIATED PROTEIN 1 LIGHT CHAIN 3 ALPHA protein binding#GO:0005515;lipid binding#GO:0008289;microtubule binding#GO:0008017;binding#GO:0005488;enzyme binding#GO:0019899;ubiquitin protein ligase binding#GO:0031625;phospholipid binding#GO:0005543;ubiquitin-like protein ligase binding#GO:0044389;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631 cellular component organization#GO:0016043;response to starvation#GO:0042594;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;catabolic process#GO:0009056;protein-containing complex disassembly#GO:0032984;organelle assembly#GO:0070925;cellular response to stress#GO:0033554;cellular component disassembly#GO:0022411;process utilizing autophagic mechanism#GO:0061919;vacuole organization#GO:0007033;response to stress#GO:0006950;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;response to nutrient levels#GO:0031667;cellular process#GO:0009987;autophagosome organization#GO:1905037;autophagy#GO:0006914;cellular component assembly#GO:0022607;macroautophagy#GO:0016236;autophagosome maturation#GO:0097352;autophagy of mitochondrion#GO:0000422;metabolic process#GO:0008152;cellular response to starvation#GO:0009267;cellular response to nutrient levels#GO:0031669;cellular component organization or biogenesis#GO:0071840;mitophagy#GO:0000423;autophagosome assembly#GO:0000045;protein-containing complex organization#GO:0043933 intracellular organelle#GO:0043229;autophagosome#GO:0005776;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;autophagosome membrane#GO:0000421;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;vacuolar membrane#GO:0005774;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;vacuole#GO:0005773;cellular anatomical structure#GO:0110165;organelle#GO:0043226 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=32378|UniProtKB=P0DX52 P0DX52 GOLGA8F PTHR10881:SF7 GOLGIN SUBFAMILY A MEMBER-RELATED GOLGIN SUBFAMILY A CONSERVED DOMAIN-CONTAINING PROTEIN-RELATED organelle organization#GO:0006996;cellular component organization#GO:0016043;Golgi organization#GO:0007030;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;endomembrane system organization#GO:0010256 Golgi apparatus#GO:0005794;organelle membrane#GO:0031090;cis-Golgi network#GO:0005801;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;endomembrane system#GO:0012505;Golgi cisterna#GO:0031985;cytoplasm#GO:0005737;Golgi cis cisterna#GO:0000137;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;Golgi stack#GO:0005795;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 membrane traffic protein#PC00150 HUMAN|HGNC=9587|UniProtKB=P48651 P48651 PTDSS1 PTHR15362:SF15 PHOSPHATIDYLINOSITOL SYNTHASE PHOSPHATIDYLSERINE SYNTHASE 1 transferase#PC00220 HUMAN|HGNC=989|UniProtKB=O95999 O95999 BCL10 PTHR34920:SF1 B-CELL LYMPHOMA/LEUKEMIA 10 B-CELL LYMPHOMA_LEUKEMIA 10 transcription factor binding#GO:0008134;transcription coregulator activity#GO:0003712;molecular function regulator activity#GO:0098772;kinase activator activity#GO:0019209;enzyme activator activity#GO:0008047;transcription coactivator activity#GO:0003713;kinase regulator activity#GO:0019207;binding#GO:0005488;kinase binding#GO:0019900;transcription regulator activity#GO:0140110;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629;enzyme regulator activity#GO:0030234;protein binding#GO:0005515;DNA-binding transcription factor binding#GO:0140297;molecular function activator activity#GO:0140677 positive regulation of extrinsic apoptotic signaling pathway#GO:2001238;positive regulation of apoptotic process#GO:0043065;regulation of response to stimulus#GO:0048583;regulation of apoptotic process#GO:0042981;adaptive immune response#GO:0002250;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of response to stimulus#GO:0048584;immune response#GO:0006955;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of signaling#GO:0023056;regulation of apoptotic signaling pathway#GO:2001233;regulation of signaling#GO:0023051;immune system process#GO:0002376;positive regulation of apoptotic signaling pathway#GO:2001235;regulation of cell communication#GO:0010646;positive regulation of programmed cell death#GO:0043068;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;regulation of extrinsic apoptotic signaling pathway#GO:2001236;regulation of programmed cell death#GO:0043067 cytosol#GO:0005829;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=18484|UniProtKB=Q8NEJ0 Q8NEJ0 DUSP18 PTHR46495:SF1 DUAL SPECIFICITY PROTEIN PHOSPHATASE 21 DUAL SPECIFICITY PROTEIN PHOSPHATASE 18 catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725;phosphoprotein phosphatase activity#GO:0004721 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protein phosphatase#PC00195 Oxidative stress response#P00046>MKP5#P01131 HUMAN|HGNC=16228|UniProtKB=Q96RU7 Q96RU7 TRIB3 PTHR22961:SF14 SER/THR PROTEIN KINASE-TRB TRIBBLES HOMOLOG 3 protein binding#GO:0005515;binding#GO:0005488;kinase binding#GO:0019900;enzyme binding#GO:0019899;protein kinase binding#GO:0019901 positive regulation of proteasomal protein catabolic process#GO:1901800;positive regulation of ubiquitin-dependent protein catabolic process#GO:2000060;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of protein metabolic process#GO:0051247;positive regulation of metabolic process#GO:0009893;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434;regulation of protein catabolic process#GO:0042176;positive regulation of protein catabolic process#GO:0045732;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;regulation of primary metabolic process#GO:0080090;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of proteasomal protein catabolic process#GO:0061136;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032436;biological regulation#GO:0065007;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;positive regulation of catabolic process#GO:0009896;regulation of catabolic process#GO:0009894 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=28068|UniProtKB=Q86T29 Q86T29 ZNF605 PTHR24377:SF120 IP01015P-RELATED ZINC FINGER PROTEIN 605 double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=15987|UniProtKB=O76003 O76003 GLRX3 PTHR10293:SF74 GLUTAREDOXIN FAMILY MEMBER GLUTAREDOXIN-3 disulfide oxidoreductase activity#GO:0015036;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667 cellular component assembly#GO:0022607;monoatomic ion homeostasis#GO:0050801;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;intracellular iron ion homeostasis#GO:0006879;homeostatic process#GO:0042592;iron-sulfur cluster assembly#GO:0016226;cellular component organization#GO:0016043;intracellular monoatomic ion homeostasis#GO:0006873;inorganic ion homeostasis#GO:0098771 cytosol#GO:0005829;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 oxidoreductase#PC00176;reductase#PC00198 HUMAN|HGNC=34453|UniProtKB=A6NNL5 A6NNL5 C15orf61 PTHR34651:SF1 SIMILAR TO ENSANGP00000021391 SIMILAR TO HUMAN CHROMOSOME 15 OPEN READING FRAME 61 HUMAN|HGNC=10705|UniProtKB=P53992 P53992 SEC24C PTHR13803:SF5 SEC24-RELATED PROTEIN PROTEIN TRANSPORT PROTEIN SEC24C zinc ion binding#GO:0008270;SNARE binding#GO:0000149;transition metal ion binding#GO:0046914;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;cation binding#GO:0043169;protein binding#GO:0005515;metal ion binding#GO:0046872 cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;vesicle organization#GO:0016050;vesicle budding from membrane#GO:0006900;intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;transport#GO:0006810;vesicle-mediated transport#GO:0016192;membrane organization#GO:0061024;organelle organization#GO:0006996;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;localization#GO:0051179;cellular localization#GO:0051641;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;COPII-coated vesicle budding#GO:0090114;cellular component organization#GO:0016043 COPII-coated ER to Golgi transport vesicle#GO:0030134;membrane coat#GO:0030117;coated membrane#GO:0048475;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;coated vesicle#GO:0030135;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;coated vesicle membrane#GO:0030662;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;vesicle#GO:0031982;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;endoplasmic reticulum#GO:0005783;endoplasmic reticulum exit site#GO:0070971;ER to Golgi transport vesicle membrane#GO:0012507;transport vesicle membrane#GO:0030658;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;transport vesicle#GO:0030133;cytoplasm#GO:0005737;vesicle coat#GO:0030120;membrane#GO:0016020;vesicle membrane#GO:0012506 vesicle coat protein#PC00235 HUMAN|HGNC=3561|UniProtKB=P51161 P51161 FABP6 PTHR11955:SF69 FATTY ACID BINDING PROTEIN GASTROTROPIN lipid binding#GO:0008289;fatty acid binding#GO:0005504;organic acid binding#GO:0043177;small molecule binding#GO:0036094;binding#GO:0005488;anion binding#GO:0043168;carboxylic acid binding#GO:0031406;ion binding#GO:0043167 macromolecule localization#GO:0033036;lipid transport#GO:0006869;organic acid transport#GO:0015849;transport#GO:0006810;carboxylic acid transport#GO:0046942;lipid localization#GO:0010876;monocarboxylic acid transport#GO:0015718;fatty acid transport#GO:0015908;localization#GO:0051179;establishment of localization#GO:0051234 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 transfer/carrier protein#PC00219 HUMAN|HGNC=24928|UniProtKB=Q8NEZ2 Q8NEZ2 VPS37A PTHR13678:SF20 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37A establishment of protein localization to membrane#GO:0090150;protein targeting to vacuole#GO:0006623;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;metabolic process#GO:0008152;protein targeting to membrane#GO:0006612;macromolecule catabolic process#GO:0009057;intracellular protein transport#GO:0006886;establishment of protein localization to vacuole#GO:0072666;protein targeting#GO:0006605;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;cellular localization#GO:0051641;protein transport#GO:0015031;macromolecule localization#GO:0033036;ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043162;intracellular transport#GO:0046907;vacuolar transport#GO:0007034;transport#GO:0006810;macromolecule metabolic process#GO:0043170;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;protein localization to organelle#GO:0033365;protein localization to vacuole#GO:0072665;localization within membrane#GO:0051668;localization#GO:0051179;protein metabolic process#GO:0019538 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768;endosome membrane#GO:0010008;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;vesicle membrane#GO:0012506;ESCRT I complex#GO:0000813;membrane#GO:0016020 membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=24249|UniProtKB=Q9Y2Z4 Q9Y2Z4 YARS2 PTHR11766:SF0 TYROSYL-TRNA SYNTHETASE TYROSINE--TRNA LIGASE, MITOCHONDRIAL catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;ligase activity#GO:0016874 macromolecule metabolic process#GO:0043170;amino acid activation#GO:0043038;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;gene expression#GO:0010467;tRNA aminoacylation for protein translation#GO:0006418;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;tRNA aminoacylation#GO:0043039;mitochondrial gene expression#GO:0140053;mitochondrial RNA metabolic process#GO:0000959;RNA metabolic process#GO:0016070;protein metabolic process#GO:0019538;translation#GO:0006412;mitochondrial translation#GO:0032543;protein biosynthetic process#GO:0160307;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 translational protein#PC00263;aminoacyl-tRNA synthetase#PC00047 HUMAN|HGNC=2741|UniProtKB=Q9NVP1 Q9NVP1 DDX18 PTHR24031:SF634 RNA HELICASE ATP-DEPENDENT RNA HELICASE DDX18 metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;RNA processing#GO:0006396;maturation of LSU-rRNA#GO:0000470;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;ribosomal large subunit biogenesis#GO:0042273;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613 membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228;organelle lumen#GO:0043233;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;preribosome#GO:0030684;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031;RNA helicase#PC00032 HUMAN|HGNC=15175|UniProtKB=Q8NGJ1 Q8NGJ1 OR4D6 PTHR48002:SF23 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 4D6 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=16996|UniProtKB=Q15363 Q15363 TMED2 PTHR22811:SF50 TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN 2 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;cargo adaptor activity#GO:0140312 intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;transport#GO:0006810;Golgi vesicle transport#GO:0048193;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;endomembrane system organization#GO:0010256;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;organelle organization#GO:0006996;macromolecule localization#GO:0033036;protein transport#GO:0015031;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;localization#GO:0051179;Golgi organization#GO:0007030;cellular component organization#GO:0016043 cytoplasm#GO:0005737;endomembrane system#GO:0012505;endoplasmic reticulum#GO:0005783;Golgi apparatus#GO:0005794;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;intracellular vesicle#GO:0097708;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;coated vesicle#GO:0030135;membrane-bounded organelle#GO:0043227;COPII-coated ER to Golgi transport vesicle#GO:0030134;intracellular organelle#GO:0043229 membrane traffic protein#PC00150;vesicle coat protein#PC00235 HUMAN|HGNC=10810|UniProtKB=O00141 O00141 SGK1 PTHR24356:SF300 SERINE/THREONINE-PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE SGK1 kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;ion channel regulator activity#GO:0099106;molecular function regulator activity#GO:0098772;catalytic activity, acting on a protein#GO:0140096;transporter regulator activity#GO:0141108;potassium channel regulator activity#GO:0015459;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;channel regulator activity#GO:0016247;phosphotransferase activity, alcohol group as acceptor#GO:0016773 system development#GO:0048731;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;anatomical structure development#GO:0048856;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;multicellular organismal process#GO:0032501;neuron development#GO:0048666;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;signaling#GO:0023052;cell development#GO:0048468;cell projection organization#GO:0030030;response to stimulus#GO:0050896;cell differentiation#GO:0030154;cell morphogenesis#GO:0000902;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;cell projection morphogenesis#GO:0048858;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;nervous system development#GO:0007399;signal transduction#GO:0007165;cellular process#GO:0009987;neuron projection development#GO:0031175 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=10596|UniProtKB=Q9UQD0 Q9UQD0 SCN8A PTHR10037:SF23 VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM SODIUM CHANNEL PROTEIN TYPE 8 SUBUNIT ALPHA monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;transporter activity#GO:0005215;sodium channel activity#GO:0005272;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;voltage-gated sodium channel activity#GO:0005248;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216 sensory perception#GO:0007600;nervous system process#GO:0050877;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;action potential#GO:0001508;sodium ion transport#GO:0006814;sensory perception of pain#GO:0019233;membrane depolarization#GO:0051899;metal ion transport#GO:0030001;transport#GO:0006810;system process#GO:0003008;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;biological regulation#GO:0065007;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;multicellular organismal process#GO:0032501 neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;cation channel complex#GO:0034703;transporter complex#GO:1990351;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165;axon#GO:0030424;sodium channel complex#GO:0034706;transmembrane transporter complex#GO:1902495 voltage-gated ion channel#PC00241 HUMAN|HGNC=9476|UniProtKB=Q92743 Q92743 HTRA1 PTHR22939:SF13 SERINE PROTEASE FAMILY S1C HTRA-RELATED SERINE PROTEASE HTRA1 catalytic activity#GO:0003824;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;serine-type peptidase activity#GO:0008236;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787 proteolysis#GO:0006508;protein metabolic process#GO:0019538;regulation of programmed cell death#GO:0043067;primary metabolic process#GO:0044238;programmed cell death#GO:0012501;regulation of biological process#GO:0050789;cell death#GO:0008219;regulation of cellular process#GO:0050794;positive regulation of programmed cell death#GO:0043068;metabolic process#GO:0008152;regulation of apoptotic process#GO:0042981;macromolecule metabolic process#GO:0043170;positive regulation of apoptotic process#GO:0043065;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576 protease#PC00190;serine protease#PC00203 HUMAN|HGNC=19336|UniProtKB=Q149N8 Q149N8 SHPRH PTHR45865:SF2 E3 UBIQUITIN-PROTEIN LIGASE SHPRH FAMILY MEMBER E3 UBIQUITIN-PROTEIN LIGASE SHPRH transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842 protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;response to stress#GO:0006950;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;DNA damage response#GO:0006974;response to stimulus#GO:0050896;primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;cellular response to stimulus#GO:0051716;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein modification by small protein conjugation or removal#GO:0070647;cellular response to stress#GO:0033554 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=23282|UniProtKB=Q8N307 Q8N307 MUC20 PTHR37358:SF1 MUCIN-20 MUCIN-20 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cell surface receptor signaling pathway#GO:0007166;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154 HUMAN|HGNC=14633|UniProtKB=P82987 P82987 ADAMTSL3 PTHR13723:SF169 ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE ADAMTS-LIKE PROTEIN 3 metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;metalloendopeptidase activity#GO:0004222;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096 external encapsulating structure organization#GO:0045229;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;protein metabolic process#GO:0019538;extracellular matrix organization#GO:0030198;proteolysis#GO:0006508;metabolic process#GO:0008152;extracellular structure organization#GO:0043062;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization#GO:0016043 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 HUMAN|HGNC=21209|UniProtKB=A6NKF2 A6NKF2 ARID3C PTHR15348:SF2 AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN ARID DOMAIN- CONTAINING PROTEIN DEAD RINGER PROTEIN B-CELL REGULATOR OF IGH TRANSCRIPTION BRIGHT AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 3C DNA binding#GO:0003677;binding#GO:0005488;nucleic acid binding#GO:0003676 regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=15672|UniProtKB=Q9H6U8 Q9H6U8 ALG9 PTHR22760:SF2 GLYCOSYLTRANSFERASE ALPHA-1,2-MANNOSYLTRANSFERASE ALG9 hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;catalytic activity#GO:0003824;mannosyltransferase activity#GO:0000030;glycosyltransferase activity#GO:0016757 macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;biosynthetic process#GO:0009058;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229 glycosyltransferase#PC00111 HUMAN|HGNC=9039|UniProtKB=O60733 O60733 PLA2G6 PTHR24139:SF34 CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 85_88 KDA CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 A2-type glycerophospholipase activity#GO:0004623;phospholipase activity#GO:0120569;hydrolase activity, acting on ester bonds#GO:0016788;deacylase activity#GO:0160215;catalytic activity#GO:0003824;glycerophospholipase activity#GO:0004620;hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689;thiolester hydrolase activity#GO:0016790;fatty acyl-CoA hydrolase activity#GO:0047617;lipase activity#GO:0016298;acyl-CoA hydrolase activity#GO:0016289 regulation of biosynthetic process#GO:0009889;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;biological regulation#GO:0065007;glycerophospholipid metabolic process#GO:0006650;regulation of lipid biosynthetic process#GO:0046890;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;organophosphate metabolic process#GO:0019637;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;regulation of lipid metabolic process#GO:0019216;phospholipid metabolic process#GO:0006644;regulation of cellular component biogenesis#GO:0044087;glycerolipid metabolic process#GO:0046486;phosphatidylglycerol metabolic process#GO:0046471;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 lipase#PC00143;phospholipase#PC00186 Gonadotropin-releasing hormone receptor pathway#P06664>PLA2#P06738 HUMAN|HGNC=26354|UniProtKB=Q96LJ8 Q96LJ8 UBXN10 PTHR23322:SF28 FAS-ASSOCIATED PROTEIN UBX DOMAIN-CONTAINING PROTEIN 10 ubiquitin binding#GO:0043130;binding#GO:0005488;protein binding#GO:0005515 cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;response to endoplasmic reticulum stress#GO:0034976;ERAD pathway#GO:0036503;protein metabolic process#GO:0019538;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;catabolic process#GO:0009056;response to stimulus#GO:0050896;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;response to stress#GO:0006950;proteasomal protein catabolic process#GO:0010498;response to chemical#GO:0042221 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 scaffold/adaptor protein#PC00226 HUMAN|HGNC=29268|UniProtKB=A5YM72 A5YM72 CARNS1 PTHR48066:SF1 CARNOSINE SYNTHASE 1 CARNOSINE SYNTHASE 1 ribonucleoside triphosphate phosphatase activity#GO:0017111;ligase activity#GO:0016874;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ligase activity, forming carbon-nitrogen bonds#GO:0016879;ATP hydrolysis activity#GO:0016887;hydrolase activity#GO:0016787;ATP-dependent activity#GO:0140657;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818 small molecule metabolic process#GO:0044281;amino acid metabolic process#GO:0006520;biosynthetic process#GO:0009058;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;carboxylic acid biosynthetic process#GO:0046394;cellular process#GO:0009987;amino acid biosynthetic process#GO:0008652;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;small molecule biosynthetic process#GO:0044283 HUMAN|HGNC=6211|UniProtKB=P23352 P23352 ANOS1 PTHR14131:SF5 ANOSMIN ANOSMIN-1 cellular process#GO:0009987;cell differentiation#GO:0030154;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;animal gross anatomical part developmental process#GO:0160108;neuron differentiation#GO:0030182;developmental process#GO:0032502;generation of neurons#GO:0048699;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;anatomical structure development#GO:0048856;system development#GO:0048731;neurogenesis#GO:0022008 cell surface#GO:0009986;cellular anatomical structure#GO:0110165 extracellular matrix protein#PC00102 HUMAN|HGNC=5174|UniProtKB=Q7Z444 Q7Z444 ERAS PTHR24070:SF369 RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY GTPASE ERAS pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111 Ras protein signal transduction#GO:0007265;intracellular signal transduction#GO:0035556;regulation of cell population proliferation#GO:0042127;cell communication#GO:0007154;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;positive regulation of cell population proliferation#GO:0008284;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 small GTPase#PC00208 HUMAN|HGNC=28589|UniProtKB=Q8TB03 Q8TB03 CXorf38 PTHR35083:SF1 RGD1565685 PROTEIN RGD1565685 PROTEIN HUMAN|HGNC=23762|UniProtKB=Q8WXT5 Q8WXT5 FOXD4L4 PTHR11829:SF420 FORKHEAD BOX PROTEIN FORKHEAD BOX PROTEIN D4-LIKE 3-RELATED RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;developmental process#GO:0032502;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 winged helix/forkhead transcription factor#PC00246;gene-specific transcriptional regulator#PC00264;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=6129|UniProtKB=P78413 P78413 IRX4 PTHR11211:SF16 IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX-4 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690 regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;cell development#GO:0048468;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;nervous system development#GO:0007399;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;neuron differentiation#GO:0030182;developmental process#GO:0032502;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;multicellular organism development#GO:0007275;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=3671|UniProtKB=Q92915 Q92915 FGF14 PTHR11486:SF18 FIBROBLAST GROWTH FACTOR FIBROBLAST GROWTH FACTOR 14 signaling receptor regulator activity#GO:0030545;growth factor activity#GO:0008083;ion channel regulator activity#GO:0099106;growth factor receptor binding#GO:0070851;receptor ligand activity#GO:0048018;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;fibroblast growth factor receptor binding#GO:0005104;transporter regulator activity#GO:0141108;binding#GO:0005488;signaling receptor binding#GO:0005102;channel regulator activity#GO:0016247;molecular function activator activity#GO:0140677;protein binding#GO:0005515 cellular developmental process#GO:0048869;positive regulation of MAPK cascade#GO:0043410;neurogenesis#GO:0022008;response to fibroblast growth factor#GO:0071774;positive regulation of intracellular signal transduction#GO:1902533;developmental process#GO:0032502;regulation of cell migration#GO:0030334;regulation of response to stimulus#GO:0048583;positive regulation of response to stimulus#GO:0048584;fibroblast growth factor receptor signaling pathway#GO:0008543;multicellular organismal process#GO:0032501;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;positive regulation of cellular process#GO:0048522;regulation of cell motility#GO:2000145;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;system development#GO:0048731;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;response to growth factor#GO:0070848;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;multicellular organism development#GO:0007275;regulation of MAPK cascade#GO:0043408;cell surface receptor signaling pathway#GO:0007166;nervous system development#GO:0007399;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to fibroblast growth factor stimulus#GO:0044344;positive regulation of signaling#GO:0023056;cellular response to growth factor stimulus#GO:0071363;regulation of intracellular signal transduction#GO:1902531;animal gross anatomical part developmental process#GO:0160108;regulation of signaling#GO:0023051;cell differentiation#GO:0030154;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;signaling#GO:0023052;positive regulation of cell population proliferation#GO:0008284;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789 nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;extracellular region#GO:0005576;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 intercellular signal molecule#PC00207;growth factor#PC00112 FGF signaling pathway#P00021>FGF#P00623 HUMAN|HGNC=28274|UniProtKB=Q96GL9 Q96GL9 FAM163A PTHR31914:SF2 PROTEIN FAM163A PROTEIN FAM163A HUMAN|HGNC=28561|UniProtKB=Q8IXW0 Q8IXW0 LMNTD2 PTHR19956:SF5 LAMIN TAIL DOMAIN-CONTAINING PROTEIN 2 LAMIN TAIL DOMAIN-CONTAINING PROTEIN 2 structural molecule activity#GO:0005198 cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;intermediate filament#GO:0005882;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;endomembrane system#GO:0012505;nuclear envelope#GO:0005635;intracellular membraneless organelle#GO:0043232;nuclear periphery#GO:0034399;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;organelle envelope#GO:0031967;organelle lumen#GO:0043233;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=4381|UniProtKB=Q14344 Q14344 GNA13 PTHR10218:SF85 GTP-BINDING PROTEIN ALPHA SUBUNIT GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-13 hydrolase activity#GO:0016787;protein binding#GO:0005515;GTPase activity#GO:0003924;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;signaling receptor binding#GO:0005102;molecular function regulator activity#GO:0098772;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity, acting on acid anhydrides#GO:0016817;G protein-coupled receptor binding#GO:0001664;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;Rho protein signal transduction#GO:0007266;intracellular signal transduction#GO:0035556;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;signal transduction#GO:0007165;cellular process#GO:0009987;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124 extrinsic component of membrane#GO:0019898;extrinsic component of plasma membrane#GO:0019897;apical part of cell#GO:0045177;cytoplasmic side of membrane#GO:0098562;plasma membrane#GO:0005886;cytoplasm#GO:0005737;plasma membrane region#GO:0098590;brush border membrane#GO:0031526;protein-containing complex#GO:0032991;cell periphery#GO:0071944;brush border#GO:0005903;membrane#GO:0016020;cluster of actin-based cell projections#GO:0098862;intracellular anatomical structure#GO:0005622;cell projection membrane#GO:0031253;side of membrane#GO:0098552;catalytic complex#GO:1902494;extrinsic component of cytoplasmic side of plasma membrane#GO:0031234;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;apical plasma membrane#GO:0016324;cytoplasmic side of plasma membrane#GO:0009898 heterotrimeric G-protein#PC00117;G-protein#PC00020 HUMAN|HGNC=25230|UniProtKB=Q5TGY3 Q5TGY3 AHDC1 PTHR15617:SF1 TRANSCRIPTION FACTOR GIBBIN TRANSCRIPTION FACTOR GIBBIN HUMAN|HGNC=33234|UniProtKB=Q96GY3 Q96GY3 LIN37 PTHR31336:SF3 LIN37 HOMOLOG PROTEIN LIN-37 HOMOLOG negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892 intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229 HUMAN|HGNC=11945|UniProtKB=P19237 P19237 TNNI1 PTHR13738:SF9 TROPONIN I TROPONIN I, SLOW SKELETAL MUSCLE binding#GO:0005488;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515 heart process#GO:0003015;muscle system process#GO:0003012;striated muscle contraction#GO:0006941;skeletal muscle contraction#GO:0003009;multicellular organismal process#GO:0032501;blood circulation#GO:0008015;nervous system process#GO:0050877;cardiac muscle contraction#GO:0060048;muscle contraction#GO:0006936;neuromuscular process#GO:0050905;circulatory system process#GO:0003013;heart contraction#GO:0060047;system process#GO:0003008 contractile muscle fiber#GO:0043292;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;sarcomere#GO:0030017;actin cytoskeleton#GO:0015629;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;myofibril#GO:0030016;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512 non-motor actin binding protein#PC00165 HUMAN|HGNC=27475|UniProtKB=Q86XJ1 Q86XJ1 GAS2L3 PTHR46756:SF7 TRANSGELIN GAS2-LIKE PROTEIN 3 protein-containing complex binding#GO:0044877;protein binding#GO:0005515;actin binding#GO:0003779;actin filament binding#GO:0051015;cytoskeletal protein binding#GO:0008092;binding#GO:0005488 actin filament-based process#GO:0030029;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036 cytoskeletal protein#PC00085 HUMAN|HGNC=28174|UniProtKB=Q8NBV4 Q8NBV4 PLPP7 PTHR14969:SF17 SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE INACTIVE PHOSPHOLIPID PHOSPHATASE 7 hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788 phospholipid dephosphorylation#GO:0046839;cellular process#GO:0009987;phosphate-containing compound metabolic process#GO:0006796;primary metabolic process#GO:0044238;lipid modification#GO:0030258;dephosphorylation#GO:0016311;lipid metabolic process#GO:0006629;metabolic process#GO:0008152 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;organelle envelope#GO:0031967;nucleus#GO:0005634;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635 hydrolase#PC00121;phosphatase#PC00181 HUMAN|HGNC=15470|UniProtKB=O75937 O75937 DNAJC8 PTHR15606:SF7 DNAJ HOMOLOG SUBFAMILY C MEMBER 8/LIPOPOLYSACCHARIDE SPECIFIC RESPONSE-7-RELATED DNAJ HOMOLOG SUBFAMILY C MEMBER 8 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 chaperone#PC00072 HUMAN|HGNC=9801|UniProtKB=P63000 P63000 RAC1 PTHR24072:SF395 RHO FAMILY GTPASE RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1 kinase binding#GO:0019900;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;nucleoside phosphate binding#GO:1901265;guanyl nucleotide binding#GO:0019001;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;protein binding#GO:0005515;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;hydrolase activity, acting on acid anhydrides#GO:0016817;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;anion binding#GO:0043168;small molecule binding#GO:0036094;GTPase activity#GO:0003924;ion binding#GO:0043167;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleotide binding#GO:0000166 regulation of anatomical structure morphogenesis#GO:0022603;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;neuron differentiation#GO:0030182;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;intracellular signaling cassette#GO:0141124;cellular process#GO:0009987;signal transduction#GO:0007165;cell projection assembly#GO:0030031;organelle organization#GO:0006996;neuron projection development#GO:0031175;cellular component biogenesis#GO:0044085;regulation of biological quality#GO:0065008;neuron development#GO:0048666;axonogenesis#GO:0007409;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;cell morphogenesis#GO:0000902;response to stimulus#GO:0050896;regulation of cellular component organization#GO:0051128;regulation of cell shape#GO:0008360;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;neurogenesis#GO:0022008;actin filament organization#GO:0007015;neuron projection guidance#GO:0097485;neuron projection morphogenesis#GO:0048812;regulation of cell migration#GO:0030334;regulation of locomotion#GO:0040012;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;axon guidance#GO:0007411;anatomical structure development#GO:0048856;actin filament-based process#GO:0030029;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;cell projection morphogenesis#GO:0048858;plasma membrane bounded cell projection morphogenesis#GO:0120039;regulation of actin cytoskeleton organization#GO:0032956;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;Rac protein signal transduction#GO:0016601;generation of neurons#GO:0048699;establishment or maintenance of cell polarity#GO:0007163;signaling#GO:0023052;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cellular component organization#GO:0016043;motor neuron axon guidance#GO:0008045;cellular developmental process#GO:0048869;developmental process#GO:0032502;regulation of actin filament-based process#GO:0032970;plasma membrane bounded cell projection organization#GO:0120036;axon development#GO:0061564;intracellular signal transduction#GO:0035556;system development#GO:0048731;supramolecular fiber organization#GO:0097435;cell communication#GO:0007154;regulation of cell motility#GO:2000145;cortical cytoskeleton organization#GO:0030865;regulation of developmental process#GO:0050793;actin cytoskeleton organization#GO:0030036;regulation of cytoskeleton organization#GO:0051493 vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cell periphery#GO:0071944;membrane#GO:0016020;cytoplasm#GO:0005737;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228 small GTPase#PC00208;G-protein#PC00020 CCKR signaling map#P06959>RAC1-GTP#P07214;Huntington disease#P00029>Rac#P00775;EGF receptor signaling pathway#P00018>Rac#P00564;Ras Pathway#P04393>Rac#P04559;Axon guidance mediated by semaphorins#P00007>Rac#P00340;VEGF signaling pathway#P00056>Rac#P01421;CCKR signaling map#P06959>RAC1-GDP#P07225;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Cdc42#P00834;Integrin signalling pathway#P00034>Rac#P00927;T cell activation#P00053>rac#P01324;Gonadotropin-releasing hormone receptor pathway#P06664>Rac1#P06860;FGF signaling pathway#P00021>Rac#P00645;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Rac#P00872;Cytoskeletal regulation by Rho GTPase#P00016>Rac#P00523;Axon guidance mediated by netrin#P00009>Rac#P00366;p38 MAPK pathway#P05918>Rac#P06021;Axon guidance mediated by Slit/Robo#P00008>Rac#P00354;B cell activation#P00010>Rac#P00385 HUMAN|HGNC=6169|UniProtKB=Q14624 Q14624 ITIH4 PTHR10338:SF119 INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H4 protease inhibitor#PC00191;protein-binding activity modulator#PC00095 HUMAN|HGNC=30025|UniProtKB=Q5VV67 Q5VV67 PPRC1 PTHR15528:SF5 PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1 PGC-1 -RELATED PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA COACTIVATOR-RELATED PROTEIN 1 transcription coactivator activity#GO:0003713;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;multicellular organismal process#GO:0032501;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of gene expression#GO:0010468;multicellular organismal-level homeostasis#GO:0048871;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;positive regulation of RNA metabolic process#GO:0051254;homeostatic process#GO:0042592;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HUMAN|HGNC=25973|UniProtKB=Q3T8J9 Q3T8J9 GON4L PTHR16088:SF3 YY1 ASSOCIATED PROTEIN-RELATED GON-4-LIKE PROTEIN transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 transcription cofactor#PC00217 HUMAN|HGNC=20528|UniProtKB=P60412 P60412 KRTAP10-11 PTHR23262:SF125 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 10-11 structural protein#PC00211 HUMAN|HGNC=2987|UniProtKB=Q14185 Q14185 DOCK1 PTHR45653:SF1 DEDICATOR OF CYTOKINESIS DEDICATOR OF CYTOKINESIS PROTEIN 1 nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085;binding#GO:0005488;enzyme binding#GO:0019899;protein binding#GO:0005515;enzyme regulator activity#GO:0030234;small GTPase binding#GO:0031267 cellular developmental process#GO:0048869;anatomical structure development#GO:0048856;syncytium formation by cell-cell fusion#GO:0000768;striated muscle cell differentiation#GO:0051146;animal gross anatomical part developmental process#GO:0160108;cell-cell fusion#GO:0140253;developmental process#GO:0032502;cell migration#GO:0016477;muscle structure development#GO:0061061;cell motility#GO:0048870;cell differentiation#GO:0030154;myoblast fusion#GO:0007520;cellular process#GO:0009987;muscle cell differentiation#GO:0042692 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;membrane#GO:0016020;cell periphery#GO:0071944 protein-binding activity modulator#PC00095;G-protein modulator#PC00022;guanyl-nucleotide exchange factor#PC00113 Integrin signalling pathway#P00034>Dock180#P00930 HUMAN|HGNC=6318|UniProtKB=O00139 O00139 KIF2A PTHR24115:SF486 KINESIN-RELATED KINESIN-LIKE PROTEIN KIF2A tubulin binding#GO:0015631;macromolecular conformation isomerase activity#GO:0120543;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;isomerase activity#GO:0016853;ribonucleoside triphosphate phosphatase activity#GO:0017111;microtubule binding#GO:0008017;polypeptide conformation or assembly isomerase activity#GO:0120544;ATP hydrolysis activity#GO:0016887;microtubule motor activity#GO:0003777;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;cytoskeletal protein binding#GO:0008092;cytoskeletal motor activity#GO:0003774;ATP-dependent activity#GO:0140657;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;protein binding#GO:0005515 cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;cilium organization#GO:0044782;plasma membrane bounded cell projection assembly#GO:0120031;organelle assembly#GO:0070925;microtubule-based movement#GO:0007018;cellular component assembly#GO:0022607;cell projection organization#GO:0030030;plasma membrane bounded cell projection organization#GO:0120036;cellular component organization#GO:0016043;cilium assembly#GO:0060271;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cell projection assembly#GO:0030031 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;microtubule#GO:0005874;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoskeleton#GO:0005856;centrosome#GO:0005813;microtubule organizing center#GO:0005815;spindle#GO:0005819;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080 microtubule or microtubule-binding cytoskeletal protein#PC00157;microtubule binding motor protein#PC00156 HUMAN|HGNC=12814|UniProtKB=P23025 P23025 XPA PTHR10142:SF0 DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS binding#GO:0005488;nucleic acid binding#GO:0003676;damaged DNA binding#GO:0003684;DNA binding#GO:0003677 DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;response to UV#GO:0009411;DNA damage response#GO:0006974;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;cellular response to abiotic stimulus#GO:0071214;chromosome organization#GO:0051276;organelle organization#GO:0006996;response to stress#GO:0006950;cellular process#GO:0009987;cellular response to light stimulus#GO:0071482;response to radiation#GO:0009314;nucleotide-excision repair#GO:0006289;interstrand cross-link repair#GO:0036297;nucleobase-containing compound metabolic process#GO:0006139;cellular response to stress#GO:0033554;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;base-excision repair#GO:0006284;nucleic acid metabolic process#GO:0090304;response to abiotic stimulus#GO:0009628;cellular response to stimulus#GO:0051716;response to light stimulus#GO:0009416;response to stimulus#GO:0050896;cellular response to environmental stimulus#GO:0104004;cellular response to radiation#GO:0071478 nucleotide-excision repair complex#GO:0000109;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 DNA metabolism protein#PC00009;damaged DNA-binding protein#PC00086 HUMAN|HGNC=1006|UniProtKB=Q8WUZ0 Q8WUZ0 BCL7C PTHR12767:SF10 BCL7 RELATED B-CELL CLL_LYMPHOMA 7 PROTEIN FAMILY MEMBER C cell communication#GO:0007154;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 nucleus#GO:0005634;chromatin#GO:0000785;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;chromosome#GO:0005694;SWI/SNF superfamily-type complex#GO:0070603;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;ATPase complex#GO:1904949;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;SWI/SNF complex#GO:0016514;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=16227|UniProtKB=Q9NUD7 Q9NUD7 C20orf96 PTHR28574:SF1 RIKEN CDNA 6820408C15 RIKEN CDNA 6820408C15 GENE HUMAN|HGNC=4492|UniProtKB=Q9HC97 Q9HC97 GPR35 PTHR24232:SF54 G-PROTEIN COUPLED RECEPTOR G PROTEIN-COUPLED RECEPTOR 35 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=37220|UniProtKB=P86481 P86481 PRR20B PTHR38819:SF1 PROLINE-RICH PROTEIN 20A-RELATED PROLINE-RICH PROTEIN 20A-RELATED HUMAN|HGNC=13139|UniProtKB=P17097 P17097 ZNF7 PTHR24377:SF189 IP01015P-RELATED ZINC FINGER PROTEIN 7 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=25187|UniProtKB=Q96BW9 Q96BW9 TAMM41 PTHR13619:SF0 PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779 organophosphate biosynthetic process#GO:0090407;phosphatidylglycerol metabolic process#GO:0046471;glycerolipid metabolic process#GO:0046486;phospholipid biosynthetic process#GO:0008654;phospholipid metabolic process#GO:0006644;phosphatidylglycerol biosynthetic process#GO:0006655;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;metabolic process#GO:0008152;glycerophospholipid biosynthetic process#GO:0046474;lipid metabolic process#GO:0006629;glycerophospholipid metabolic process#GO:0006650;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017 mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=18760|UniProtKB=Q9H6A9 Q9H6A9 PCNX3 PTHR12372:SF4 PECANEX PECANEX-LIKE PROTEIN 3 HUMAN|HGNC=29533|UniProtKB=Q9GZZ1 Q9GZZ1 NAA50 PTHR42919:SF41 N-ALPHA-ACETYLTRANSFERASE N-ALPHA-ACETYLTRANSFERASE 50 transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;protein-N-terminal amino-acid acetyltransferase activity#GO:0004596;protein N-acetyltransferase activity#GO:0034212;catalytic activity, acting on a protein#GO:0140096;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;protein-lysine-acetyltransferase activity#GO:0061733;protein N-acyltransferase activity#GO:0140186 organelle organization#GO:0006996;cell cycle#GO:0007049;cellular component organization#GO:0016043;cell cycle process#GO:0022402;cellular process#GO:0009987;mitotic sister chromatid cohesion#GO:0007064;cellular component organization or biogenesis#GO:0071840;sister chromatid cohesion#GO:0007062;chromosome organization#GO:0051276 transferase complex#GO:1990234;catalytic complex#GO:1902494;protein acetyltransferase complex#GO:0031248;acetyltransferase complex#GO:1902493;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 acetyltransferase#PC00038;transferase#PC00220 HUMAN|HGNC=43943|UniProtKB=E9PB15 E9PB15 PTGES3L PTHR22932:SF4 TELOMERASE-BINDING PROTEIN P23 HSP90 CO-CHAPERONE PROTEIN PTGES3L-RELATED protein binding#GO:0005515;protein-folding chaperone binding#GO:0051087;binding#GO:0005488;heat shock protein binding#GO:0031072;Hsp90 protein binding#GO:0051879 protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;biosynthetic process#GO:0009058;cellular component assembly#GO:0022607;protein maturation#GO:0051604;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;protein metabolic process#GO:0019538;chaperone-mediated protein complex assembly#GO:0051131;protein folding#GO:0006457;protein-containing complex assembly#GO:0065003;primary metabolic process#GO:0044238;cellular component organization#GO:0016043 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 chaperone#PC00072 HUMAN|HGNC=11133|UniProtKB=O95721 O95721 SNAP29 PTHR19305:SF42 SYNAPTOSOMAL ASSOCIATED PROTEIN SYNAPTOSOMAL-ASSOCIATED PROTEIN 29 binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;SNARE binding#GO:0000149;molecular adaptor activity#GO:0060090;SNAP receptor activity#GO:0005484;syntaxin binding#GO:0019905;protein binding#GO:0005515 transport#GO:0006810;exocytosis#GO:0006887;vesicle organization#GO:0016050;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;cellular process#GO:0009987;membrane fusion#GO:0061025;organelle organization#GO:0006996;membrane organization#GO:0061024;organelle membrane fusion#GO:0090174;organelle fusion#GO:0048284;vesicle-mediated transport#GO:0016192;secretion by cell#GO:0032940;localization#GO:0051179;secretion#GO:0046903;cellular component organization#GO:0016043;export from cell#GO:0140352;vesicle fusion#GO:0006906 membrane protein complex#GO:0098796;membrane#GO:0016020;cell periphery#GO:0071944;SNARE complex#GO:0031201;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 SNARE protein#PC00034;membrane traffic protein#PC00150 5HT3 type receptor mediated signaling pathway#P04375>SNARE Complex#P04423;Dopamine receptor mediated signaling pathway#P05912>SNARE Complex#P05956;Beta2 adrenergic receptor signaling pathway#P04378>SNARE Complex#P04442;Beta3 adrenergic receptor signaling pathway#P04379>SNARE Complex#P04447;Opioid prodynorphin pathway#P05916>SNARE Complex#P05996;Opioid proenkephalin pathway#P05915>SNARE Complex#P05986;5HT2 type receptor mediated signaling pathway#P04374>SNARE Complex#P04415;5HT1 type receptor mediated signaling pathway#P04373>SNARE Complex#P04405;Beta1 adrenergic receptor signaling pathway#P04377>SNARE Complex#P04435;Adrenaline and noradrenaline biosynthesis#P00001>SNARE#P00072;5HT4 type receptor mediated signaling pathway#P04376>SNARE Complex#P04428;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>SNARE Complex#P01079;Metabotropic glutamate receptor group III pathway#P00039>SNARE Complex#P01042;Ionotropic glutamate receptor pathway#P00037>SNARE Complex#P01013;Cortocotropin releasing factor receptor signaling pathway#P04380>SNARE Complex#P04457;Nicotinic acetylcholine receptor signaling pathway#P00044>SNARE Complex#P01091;Oxytocin receptor mediated signaling pathway#P04391>SNARE Complex#P04532;Thyrotropin-releasing hormone receptor signaling pathway#P04394>SNARE Complex#P04582;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>SNARE Complex#P01066;Opioid proopiomelanocortin pathway#P05917>SNARE Complex#P06005;Metabotropic glutamate receptor group II pathway#P00040>SNARE Complex#P01049 HUMAN|HGNC=8749|UniProtKB=Q00536 Q00536 CDK16 PTHR24056:SF174 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE 16 protein serine/threonine kinase activity#GO:0004674;cyclin-dependent protein kinase activity#GO:0097472;cyclin-dependent protein serine/threonine kinase activity#GO:0004693;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096 cellular process#GO:0009987;neuron projection development#GO:0031175;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;vesicle-mediated transport#GO:0016192;multicellular organismal process#GO:0032501;transport#GO:0006810;neuron differentiation#GO:0030182;developmental process#GO:0032502;neurogenesis#GO:0022008;exocytosis#GO:0006887;cellular developmental process#GO:0048869;establishment of localization#GO:0051234;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;cell development#GO:0048468;export from cell#GO:0140352;cell differentiation#GO:0030154;cell projection organization#GO:0030030;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;neuron development#GO:0048666;system development#GO:0048731;secretion by cell#GO:0032940;secretion#GO:0046903;anatomical structure development#GO:0048856;localization#GO:0051179 transferase complex#GO:1990234;protein kinase complex#GO:1902911;cell junction#GO:0030054;presynapse#GO:0098793;nucleus#GO:0005634;secretory vesicle#GO:0099503;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;cytoplasm#GO:0005737;transport vesicle#GO:0030133;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;exocytic vesicle#GO:0070382;transferase complex, transferring phosphorus-containing groups#GO:0061695;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;vesicle#GO:0031982;synaptic vesicle#GO:0008021;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=10929|UniProtKB=Q14916 Q14916 SLC17A1 PTHR11662:SF26 SOLUTE CARRIER FAMILY 17 SODIUM-DEPENDENT PHOSPHATE TRANSPORT PROTEIN 1 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 inorganic anion transport#GO:0015698;phosphate ion transport#GO:0006817;localization#GO:0051179;establishment of localization#GO:0051234;transport#GO:0006810;nitrogen compound transport#GO:0071705 plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;apical plasma membrane#GO:0016324;membrane#GO:0016020;apical part of cell#GO:0045177;cell periphery#GO:0071944 secondary carrier transporter#PC00258 Ionotropic glutamate receptor pathway#P00037>Vglut#P01021 HUMAN|HGNC=6565|UniProtKB=P56470 P56470 LGALS4 PTHR11346:SF32 GALECTIN GALECTIN-4 carbohydrate binding#GO:0030246;binding#GO:0005488 extracellular matrix protein#PC00102 HUMAN|HGNC=3614|UniProtKB=Q92637 Q92637 FCGR1BP PTHR11481:SF11 IMMUNOGLOBULIN FC RECEPTOR HIGH AFFINITY IMMUNOGLOBULIN GAMMA FC RECEPTOR I-RELATED transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;cell communication#GO:0007154;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;immune system process#GO:0002376;adaptive immune response#GO:0002250;biological regulation#GO:0065007;cellular process#GO:0009987;immune response#GO:0006955;signal transduction#GO:0007165;immune effector process#GO:0002252;cell surface receptor signaling pathway#GO:0007166 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell surface#GO:0009986;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=34301|UniProtKB=Q6ZQY2 Q6ZQY2 LRRC74B PTHR24114:SF37 LEUCINE RICH REPEAT FAMILY PROTEIN LEUCINE-RICH REPEAT-CONTAINING PROTEIN 74B HUMAN|HGNC=17921|UniProtKB=Q8TEV9 Q8TEV9 SMCR8 PTHR31334:SF1 SMITH-MAGENIS SYNDROME REGION GENE 8 PROTEIN GUANINE NUCLEOTIDE EXCHANGE PROTEIN SMCR8 intracellular protein-containing complex#GO:0140535;guanyl-nucleotide exchange factor complex#GO:0032045;protein-containing complex#GO:0032991 HUMAN|HGNC=16406|UniProtKB=Q5JVL4 Q5JVL4 EFHC1 PTHR12086:SF9 EF-HAND DOMAIN C-TERMINAL CONTAINING PROTEIN EF-HAND DOMAIN-CONTAINING PROTEIN 1 cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;binding#GO:0005488;protein binding#GO:0005515 cell cycle process#GO:0022402;cell division#GO:0051301;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cellular component organization#GO:0016043;cell cycle#GO:0007049;mitotic spindle organization#GO:0007052;cell motility#GO:0048870;mitotic cytokinesis#GO:0000281;mitotic cell cycle#GO:0000278;cilium or flagellum-dependent cell motility#GO:0001539;cytokinesis#GO:0000910;microtubule cytoskeleton organization#GO:0000226;cytoskeleton-dependent cytokinesis#GO:0061640;cilium-dependent cell motility#GO:0060285;cellular process#GO:0009987;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;microtubule-based process#GO:0007017;mitotic cell cycle process#GO:1903047;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840 membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;spindle#GO:0005819;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;ciliary plasm#GO:0097014;microtubule cytoskeleton#GO:0015630;supramolecular fiber#GO:0099512;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;axoneme#GO:0005930;intracellular organelle#GO:0043229;cilium#GO:0005929;cell projection#GO:0042995;mitotic spindle#GO:0072686;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;axonemal microtubule#GO:0005879;cellular anatomical structure#GO:0110165;cytoplasmic microtubule#GO:0005881 calcium-binding protein#PC00060;calmodulin-related#PC00061 HUMAN|HGNC=15110|UniProtKB=Q8NGR8 Q8NGR8 OR1L8 PTHR48001:SF83 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 1L8 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=922|UniProtKB=Q9NPZ5 Q9NPZ5 B3GAT2 PTHR10896:SF8 GALACTOSYLGALACTOSYLXYLOSYLPROTEIN 3-BETA-GLUCURONOSYLTRANSFERASE BETA-1,3-GLUCURONYLTRANSFERASE GALACTOSYLGALACTOSYLXYLOSYLPROTEIN 3-BETA-GLUCURONOSYLTRANSFERASE 2 UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;hexosyltransferase activity#GO:0016758;glucuronosyltransferase activity#GO:0015020;transferase activity#GO:0016740;catalytic activity#GO:0003824 carbohydrate metabolic process#GO:0005975;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;chondroitin sulfate proteoglycan biosynthetic process#GO:0050650;biosynthetic process#GO:0009058;proteoglycan biosynthetic process#GO:0030166;glycoprotein biosynthetic process#GO:0009101;protein O-linked glycosylation#GO:0006493;macromolecule biosynthetic process#GO:0009059;chondroitin sulfate proteoglycan metabolic process#GO:0050654;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;proteoglycan metabolic process#GO:0006029;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 glycosyltransferase#PC00111 HUMAN|HGNC=12562|UniProtKB=Q9BZX2 Q9BZX2 UCK2 PTHR10285:SF131 URIDINE KINASE URIDINE-CYTIDINE KINASE 2 nucleoside kinase activity#GO:0019206;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;nucleobase-containing compound kinase activity#GO:0019205 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 nucleotide kinase#PC00172;kinase#PC00137 Salvage pyrimidine ribonucleotides#P02775>Uridine kinase#P03150;Salvage pyrimidine ribonucleotides#P02775>CDP kinase#P03156;Salvage pyrimidine ribonucleotides#P02775>Cytidine kinase#P03149 HUMAN|HGNC=18592|UniProtKB=Q6ZWH5 Q6ZWH5 NEK10 PTHR43671:SF92 SERINE/THREONINE-PROTEIN KINASE NEK SERINE_THREONINE-PROTEIN KINASE NEK10 protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740 regulation of cell cycle process#GO:0010564;regulation of cell cycle#GO:0051726;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of cell cycle phase transition#GO:1901987;regulation of cell cycle G2/M phase transition#GO:1902749 catalytic complex#GO:1902494;transferase complex#GO:1990234;transferase complex, transferring phosphorus-containing groups#GO:0061695;protein kinase complex#GO:1902911;protein-containing complex#GO:0032991 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=14498|UniProtKB=P82675 P82675 MRPS5 PTHR13718:SF90 RIBOSOMAL S SUBUNIT SMALL RIBOSOMAL SUBUNIT PROTEIN US5M structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 metabolic process#GO:0008152;translation#GO:0006412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;mitochondrion#GO:0005739;organelle lumen#GO:0043233;cytosolic ribosome#GO:0022626;mitochondrial ribosome#GO:0005761;organellar ribosome#GO:0000313;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrial matrix#GO:0005759;small ribosomal subunit#GO:0015935;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;cytosolic small ribosomal subunit#GO:0022627;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;membrane-enclosed lumen#GO:0031974;cytosol#GO:0005829;mitochondrial small ribosomal subunit#GO:0005763;membraneless organelle#GO:0043228 ribosomal protein#PC00202 HUMAN|HGNC=4420|UniProtKB=O43555 O43555 GNRH2 PTHR10522:SF6 GONADOLIBERIN PROGONADOLIBERIN-2 hormone receptor binding#GO:0051427;binding#GO:0005488;signaling receptor binding#GO:0005102;hormone activity#GO:0005179;molecular function activator activity#GO:0140677;protein binding#GO:0005515;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 peptide hormone#PC00179;intercellular signal molecule#PC00207 HUMAN|HGNC=27012|UniProtKB=Q6P5X5 Q6P5X5 C22orf39 PTHR28052:SF1 UPF0545 PROTEIN C22ORF39 SYNAPTIC PLASTICITY REGULATOR PANTS HUMAN|HGNC=26259|UniProtKB=Q5D1E8 Q5D1E8 ZC3H12A PTHR12876:SF10 N4BP1-RELATED ENDORIBONUCLEASE ZC3H12A catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;RNA endonuclease activity#GO:0004521;catalytic activity, acting on RNA#GO:0140098;endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723;nuclease activity#GO:0004518 positive regulation of mRNA metabolic process#GO:1903313;mRNA destabilization#GO:0061157;regulation of mRNA metabolic process#GO:1903311;RNA destabilization#GO:0050779;negative regulation of macromolecule biosynthetic process#GO:0010558;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of metabolic process#GO:0009893;regulation of biological quality#GO:0065008;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;regulation of biological process#GO:0050789;regulation of mRNA stability#GO:0043488;negative regulation of metabolic process#GO:0009892;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;regulation of biosynthetic process#GO:0009889;positive regulation of catabolic process#GO:0009896;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA stability#GO:0043487;regulation of RNA metabolic process#GO:0051252;positive regulation of mRNA catabolic process#GO:0061014;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254 nucleus#GO:0005634;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 endoribonuclease#PC00094 HUMAN|HGNC=11351|UniProtKB=Q9NRC1 Q9NRC1 ST7 PTHR12745:SF10 SUPPRESSION OF TUMORIGENICITY 7 SUPPRESSOR OF TUMORIGENICITY 7 PROTEIN HUMAN|HGNC=6317|UniProtKB=O43896 O43896 KIF1C PTHR24115:SF322 KINESIN-RELATED KINESIN-LIKE PROTEIN KIF1C ATP hydrolysis activity#GO:0016887;microtubule motor activity#GO:0003777;hydrolase activity#GO:0016787;microtubule binding#GO:0008017;polypeptide conformation or assembly isomerase activity#GO:0120544;ribonucleoside triphosphate phosphatase activity#GO:0017111;isomerase activity#GO:0016853;macromolecular conformation isomerase activity#GO:0120543;tubulin binding#GO:0015631;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;plus-end-directed microtubule motor activity#GO:0008574;protein binding#GO:0005515;ATP-dependent activity#GO:0140657;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;cytoskeletal motor activity#GO:0003774;cytoskeletal protein binding#GO:0008092;hydrolase activity, acting on acid anhydrides#GO:0016817 cellular localization#GO:0051641;localization#GO:0051179;organelle localization#GO:0051640;axonal transport#GO:0098930;retrograde axonal transport#GO:0008090;microtubule-based transport#GO:0099111;establishment of organelle localization#GO:0051656;microtubule-based movement#GO:0007018;cytosolic transport#GO:0016482;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;microtubule-based process#GO:0007017;vesicle cytoskeletal trafficking#GO:0099518;vesicle transport along microtubule#GO:0047496;intracellular transport#GO:0046907;transport#GO:0006810;vesicle-mediated transport#GO:0016192;cytoskeleton-dependent intracellular transport#GO:0030705;organelle transport along microtubule#GO:0072384;establishment of vesicle localization#GO:0051650;axo-dendritic transport#GO:0008088;cellular process#GO:0009987;vesicle localization#GO:0051648;establishment of localization in cell#GO:0051649 polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;somatodendritic compartment#GO:0036477;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;neuron projection#GO:0043005;microtubule cytoskeleton#GO:0015630;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;dendritic tree#GO:0097447;axon#GO:0030424;intracellular organelle#GO:0043229;dendrite#GO:0030425;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=28432|UniProtKB=Q8N5M4 Q8N5M4 TTC9C PTHR11242:SF14 ARYL HYDROCARBON RECEPTOR INTERACTING PROTEIN RELATED TETRATRICOPEPTIDE REPEAT PROTEIN 9C biosynthetic process#GO:0009058;protein folding#GO:0006457;protein maturation#GO:0051604;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein modification process#GO:0036211;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;membrane#GO:0016020 chaperone#PC00072 HUMAN|HGNC=14515|UniProtKB=Q9NVS2 Q9NVS2 MRPS18A PTHR13479:SF66 30S RIBOSOMAL PROTEIN S18 LARGE RIBOSOMAL SUBUNIT PROTEIN ML66 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 ribosome#GO:0005840;mitochondrion#GO:0005739;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;small ribosomal subunit#GO:0015935;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;organellar ribosome#GO:0000313;mitochondrial ribosome#GO:0005761;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;membraneless organelle#GO:0043228;mitochondrial large ribosomal subunit#GO:0005762;mitochondrial small ribosomal subunit#GO:0005763 translational protein#PC00263;ribosomal protein#PC00202 HUMAN|HGNC=28633|UniProtKB=Q8N5I2 Q8N5I2 ARRDC1 PTHR11188:SF182 ARRESTIN DOMAIN CONTAINING PROTEIN ARRESTIN DOMAIN-CONTAINING PROTEIN 1 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=16787|UniProtKB=Q9BZQ6 Q9BZQ6 EDEM3 PTHR45679:SF2 ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2 ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 3 hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 response to chemical#GO:0042221;proteasomal protein catabolic process#GO:0010498;response to stress#GO:0006950;signal transduction#GO:0007165;cellular process#GO:0009987;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;glycoprotein metabolic process#GO:0009100;response to stimulus#GO:0050896;signaling#GO:0023052;response to topologically incorrect protein#GO:0035966;regulation of biological process#GO:0050789;response to unfolded protein#GO:0006986;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;response to oxygen-containing compound#GO:1901700;biological regulation#GO:0065007;endoplasmic reticulum unfolded protein response#GO:0030968;carbohydrate derivative metabolic process#GO:1901135;macromolecule metabolic process#GO:0043170;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;carbohydrate derivative catabolic process#GO:1901136;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;protein metabolic process#GO:0019538;ERAD pathway#GO:0036503;intracellular signal transduction#GO:0035556;response to endoplasmic reticulum stress#GO:0034976;cellular response to unfolded protein#GO:0034620;cellular response to topologically incorrect protein#GO:0035967 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 HUMAN|HGNC=2608|UniProtKB=Q16696 Q16696 CYP2A13 PTHR24300:SF409 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 2A13 tetrapyrrole binding#GO:0046906;binding#GO:0005488;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen#GO:0016712;catalytic activity#GO:0003824;monooxygenase activity#GO:0004497;heme binding#GO:0020037;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705 cellular response to xenobiotic stimulus#GO:0071466;response to chemical#GO:0042221;icosanoid metabolic process#GO:0006690;cellular process#GO:0009987;long-chain fatty acid metabolic process#GO:0001676;secondary metabolic process#GO:0019748;unsaturated fatty acid metabolic process#GO:0033559;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;xenobiotic metabolic process#GO:0006805;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;arachidonate metabolic process#GO:0019369;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;response to xenobiotic stimulus#GO:0009410;oxoacid metabolic process#GO:0043436;cellular response to chemical stimulus#GO:0070887;olefinic compound metabolic process#GO:0120254 intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 oxidoreductase#PC00176;oxygenase#PC00177 Nicotine degradation#P05914>CYP2A6#P05984 HUMAN|HGNC=1248|UniProtKB=P06681 P06681 C2 PTHR46393:SF2 SUSHI DOMAIN-CONTAINING PROTEIN COMPLEMENT C2 humoral immune response#GO:0006959;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;immune effector process#GO:0002252;response to external stimulus#GO:0009605;response to biotic stimulus#GO:0009607;positive regulation of immune system process#GO:0002684;complement activation#GO:0006956;activation of immune response#GO:0002253;immune response#GO:0006955;positive regulation of biological process#GO:0048518;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;response to other organism#GO:0051707;immune system process#GO:0002376;response to bacterium#GO:0009617;regulation of immune response#GO:0050776;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of immune system process#GO:0002682;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207 HUMAN|HGNC=3607|UniProtKB=O00757 O00757 FBP2 PTHR11556:SF13 FRUCTOSE-1,6-BISPHOSPHATASE-RELATED FRUCTOSE-1,6-BISPHOSPHATASE ISOZYME 2 hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;catalytic activity#GO:0003824;sugar-phosphatase activity#GO:0050308;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788 glucose metabolic process#GO:0006006;metabolic process#GO:0008152;monosaccharide metabolic process#GO:0005996;small molecule biosynthetic process#GO:0044283;small molecule metabolic process#GO:0044281;carbohydrate metabolic process#GO:0005975;monosaccharide biosynthetic process#GO:0046364;biosynthetic process#GO:0009058;carbohydrate biosynthetic process#GO:0016051;hexose metabolic process#GO:0019318;primary metabolic process#GO:0044238;hexose biosynthetic process#GO:0019319;gluconeogenesis#GO:0006094;cellular process#GO:0009987 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 hydrolase#PC00121;carbohydrate phosphatase#PC00066;phosphatase#PC00181 HUMAN|HGNC=4015|UniProtKB=P22083 P22083 FUT4 PTHR11929:SF132 ALPHA- 1,3 -FUCOSYLTRANSFERASE ALPHA-(1,3)-FUCOSYLTRANSFERASE 4 catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758;fucosyltransferase activity#GO:0008417;glycosyltransferase activity#GO:0016757;alpha-(1->3)-fucosyltransferase activity#GO:0046920 glycosyltransferase#PC00111 HUMAN|HGNC=15891|UniProtKB=Q9NVA1 Q9NVA1 UQCC1 PTHR12184:SF1 UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX ASSEMBLY FACTOR 1 FAMILY MEMBER UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX ASSEMBLY FACTOR 1 protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;cytochrome complex assembly#GO:0017004;mitochondrion organization#GO:0007005;mitochondrial respiratory chain complex assembly#GO:0033108;mitochondrial respiratory chain complex III assembly#GO:0034551;cellular component assembly#GO:0022607;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 chaperone#PC00072 HUMAN|HGNC=26525|UniProtKB=Q6P387 Q6P387 C16orf46 PTHR36869:SF1 CHROMOSOME 16 OPEN READING FRAME 46 CHROMOSOME 16 OPEN READING FRAME 46 HUMAN|HGNC=6871|UniProtKB=P28482 P28482 MAPK1 PTHR24055:SF584 MITOGEN-ACTIVATED PROTEIN KINASE MITOGEN-ACTIVATED PROTEIN KINASE 1 phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634 non-receptor serine/threonine protein kinase#PC00167 Interferon-gamma signaling pathway#P00035>Serine kinase#P00955;Parkinson disease#P00049>ERK#P01211;Alzheimer disease-amyloid secretase pathway#P00003>MAPK#P00099;Apoptosis signaling pathway#P00006>MAPK#P00269;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>ERK#P00889;Endothelin signaling pathway#P00019>ERK#P00566;Ras Pathway#P04393>ERK#P04542;T cell activation#P00053>ERK#P01300;PDGF signaling pathway#P00047>ERK#P01143;Angiogenesis#P00005>MEK#P00225;CCKR signaling map#P06959>MAPK1/3#P07228;Integrin signalling pathway#P00034>ERK#P00907;Interleukin signaling pathway#P00036>ERK#P00965;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>MAPK#P00835;Angiotensin II-stimulated signaling through G proteins and beta-arrestin#P05911>MAPK#P05937;B cell activation#P00010>ERK#P00371;TGF-beta signaling pathway#P00052>p42/p44MAPKs#P01293;CCKR signaling map#P06959>MAPK1#P07166;VEGF signaling pathway#P00056>MEK#P01402;FGF signaling pathway#P00021>ERK1-2#P00627;EGF receptor signaling pathway#P00018>ERK1-2#P00543;Angiogenesis#P00005>Erk#P00203;Toll receptor signaling pathway#P00054>ERK2#P01356;Gonadotropin-releasing hormone receptor pathway#P06664>ERK1/2#P06786;VEGF signaling pathway#P00056>Erk#P01407 HUMAN|HGNC=9119|UniProtKB=O75439 O75439 PMPCB PTHR11851:SF103 METALLOPROTEASE MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT BETA catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233 protein localization to mitochondrion#GO:0070585;macromolecule localization#GO:0033036;intracellular protein localization#GO:0008104;protein localization to organelle#GO:0033365;localization#GO:0051179 protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;peptidase complex#GO:1905368;cytoplasm#GO:0005737;membrane-enclosed lumen#GO:0031974;endopeptidase complex#GO:1905369;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;mitochondrial matrix#GO:0005759 protease#PC00190;metalloprotease#PC00153 HUMAN|HGNC=3503|UniProtKB=Q92817 Q92817 EVPL PTHR23169:SF7 ENVOPLAKIN ENVOPLAKIN cytoskeleton organization#GO:0007010;intermediate filament cytoskeleton organization#GO:0045104;response to stimulus#GO:0050896;cellular process#GO:0009987;response to wounding#GO:0009611;cellular component organization#GO:0016043;response to stress#GO:0006950;organelle organization#GO:0006996;wound healing#GO:0042060;cellular component organization or biogenesis#GO:0071840;intermediate filament-based process#GO:0045103 membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;organelle#GO:0043226;supramolecular complex#GO:0099080;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;intermediate filament#GO:0005882;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228 intermediate filament#PC00129;intermediate filament binding protein#PC00130 HUMAN|HGNC=28961|UniProtKB=Q15004 Q15004 PCLAF PTHR15679:SF8 PCNA-ASSOCIATED FACTOR PCNA-ASSOCIATED FACTOR translesion synthesis#GO:0019985;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;DNA biosynthetic process#GO:0071897;response to stress#GO:0006950;macromolecule metabolic process#GO:0043170;DNA damage tolerance#GO:0006301;DNA damage response#GO:0006974;nucleobase-containing compound biosynthetic process#GO:0034654;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;response to stimulus#GO:0050896;DNA replication#GO:0006260;cellular response to stimulus#GO:0051716;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;DNA synthesis involved in DNA replication#GO:0090592;nucleic acid biosynthetic process#GO:0141187;cellular response to stress#GO:0033554 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=26360|UniProtKB=Q8N7J2 Q8N7J2 AMER2 PTHR22237:SF1 APC MEMBRANE RECRUITMENT PROTEIN 2-RELATED APC MEMBRANE RECRUITMENT PROTEIN 2 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;protein-membrane adaptor activity#GO:0043495 regulation of canonical Wnt signaling pathway#GO:0060828;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of Wnt signaling pathway#GO:0030111;regulation of cell communication#GO:0010646;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HUMAN|HGNC=14452|UniProtKB=Q9NYG5 Q9NYG5 ANAPC11 PTHR11210:SF1 RING BOX ANAPHASE-PROMOTING COMPLEX SUBUNIT 11 protein binding#GO:0005515;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;binding#GO:0005488;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740 regulation of mitotic metaphase/anaphase transition#GO:0030071;biological regulation#GO:0065007;post-translational protein modification#GO:0043687;regulation of nuclear division#GO:0051783;positive regulation of cellular process#GO:0048522;regulation of mitotic cell cycle#GO:0007346;macromolecule metabolic process#GO:0043170;regulation of mitotic sister chromatid separation#GO:0010965;regulation of mitotic nuclear division#GO:0007088;positive regulation of mitotic cell cycle#GO:0045931;ubiquitin-dependent protein catabolic process#GO:0006511;regulation of chromosome organization#GO:0033044;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;regulation of cell cycle phase transition#GO:1901987;primary metabolic process#GO:0044238;protein modification process#GO:0036211;modification-dependent protein catabolic process#GO:0019941;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;regulation of chromosome separation#GO:1905818;regulation of cell cycle process#GO:0010564;protein ubiquitination#GO:0016567;positive regulation of cell cycle#GO:0045787;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;positive regulation of mitotic nuclear division#GO:0045840;regulation of chromosome segregation#GO:0051983;regulation of cellular component organization#GO:0051128;regulation of cell cycle#GO:0051726;regulation of sister chromatid segregation#GO:0033045;regulation of biological process#GO:0050789;protein modification by small protein conjugation#GO:0032446;positive regulation of cell cycle process#GO:0090068;regulation of organelle organization#GO:0033043;regulation of mitotic cell cycle phase transition#GO:1901990;positive regulation of organelle organization#GO:0010638;protein modification by small protein conjugation or removal#GO:0070647;positive regulation of cellular component organization#GO:0051130;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632 catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ubiquitin ligase complex#GO:0000151;intracellular membrane-bounded organelle#GO:0043231;cullin-RING ubiquitin ligase complex#GO:0031461;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear ubiquitin ligase complex#GO:0000152;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;anaphase-promoting complex#GO:0005680;protein-containing complex#GO:0032991 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=28229|UniProtKB=Q9BRT6 Q9BRT6 LLPH PTHR34253:SF3 PROTEIN LLP HOMOLOG PROTEIN LLP HOMOLOG system development#GO:0048731;developmental growth involved in morphogenesis#GO:0060560;neuron projection extension#GO:1990138;neuron development#GO:0048666;anatomical structure development#GO:0048856;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;developmental cell growth#GO:0048588;cell development#GO:0048468;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell morphogenesis#GO:0000902;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;cell projection morphogenesis#GO:0048858;neurogenesis#GO:0022008;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;developmental growth#GO:0048589;cell growth#GO:0016049;cellular developmental process#GO:0048869;developmental process#GO:0032502;neuron differentiation#GO:0030182;neuron projection morphogenesis#GO:0048812;plasma membrane bounded cell projection morphogenesis#GO:0120039;growth#GO:0040007;plasma membrane bounded cell projection organization#GO:0120036;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;cellular process#GO:0009987;neuron projection development#GO:0031175 intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730 HUMAN|HGNC=9833|UniProtKB=Q9UQ07 Q9UQ07 MOK PTHR24055:SF533 MITOGEN-ACTIVATED PROTEIN KINASE MAPK_MAK_MRK OVERLAPPING KINASE protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=21220|UniProtKB=Q8WXF0 Q8WXF0 SRSF12 PTHR23147:SF3 SERINE/ARGININE RICH SPLICING FACTOR SERINE_ARGININE-RICH SPLICING FACTOR 12 organelle lumen#GO:0043233;nuclear speck#GO:0016607;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;cytoplasm#GO:0005737;nuclear body#GO:0016604;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228 RNA processing factor#PC00147;RNA metabolism protein#PC00031;RNA splicing factor#PC00148 HUMAN|HGNC=4932|UniProtKB=P01889 P01889 HLA-B PTHR16675:SF270 MHC CLASS I-RELATED HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, B ALPHA CHAIN antigen binding#GO:0003823;peptide binding#GO:0042277;binding#GO:0005488;signaling receptor binding#GO:0005102;protein binding#GO:0005515 regulation of immune response#GO:0050776;regulation of cell killing#GO:0031341;regulation of lymphocyte mediated immunity#GO:0002706;immune system process#GO:0002376;regulation of leukocyte mediated cytotoxicity#GO:0001910;positive regulation of lymphocyte mediated immunity#GO:0002708;antigen processing and presentation#GO:0019882;regulation of immune effector process#GO:0002697;regulation of biological process#GO:0050789;regulation of leukocyte mediated immunity#GO:0002703;positive regulation of adaptive immune response#GO:0002821;response to stimulus#GO:0050896;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;positive regulation of leukocyte mediated immunity#GO:0002705;positive regulation of cellular process#GO:0048522;immune response#GO:0006955;positive regulation of biological process#GO:0048518;positive regulation of immune system process#GO:0002684;biological regulation#GO:0065007;positive regulation of immune effector process#GO:0002699;positive regulation of response to stimulus#GO:0048584 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;cell periphery#GO:0071944;membrane#GO:0016020;side of membrane#GO:0098552;external side of plasma membrane#GO:0009897;extracellular region#GO:0005576 major histocompatibility complex protein#PC00149;defense/immunity protein#PC00090 HUMAN|HGNC=20186|UniProtKB=Q9H7Z3 Q9H7Z3 NRDE2 PTHR13471:SF0 TETRATRICOPEPTIDE-LIKE HELICAL NUCLEAR EXOSOME REGULATOR NRDE2 negative regulation of gene expression, epigenetic#GO:0045814;cellular component organization or biogenesis#GO:0071840;negative regulation of RNA metabolic process#GO:0051253;heterochromatin organization#GO:0070828;cellular component assembly#GO:0022607;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulatory ncRNA-mediated heterochromatin formation#GO:0031048;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulatory ncRNA-mediated gene silencing#GO:0031047;negative regulation of cellular process#GO:0048523;negative regulation of RNA catabolic process#GO:1902369;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;negative regulation of catabolic process#GO:0009895;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;heterochromatin formation#GO:0031507 HUMAN|HGNC=1485|UniProtKB=A6NHC0 A6NHC0 CAPN8 PTHR10183:SF374 CALPAIN CALPAIN-8 cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;cysteine-type endopeptidase activity#GO:0004197;endopeptidase activity#GO:0004175 primary metabolic process#GO:0044238;metabolic process#GO:0008152;proteolysis#GO:0006508;cellular process#GO:0009987;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 cysteine protease#PC00081;protease#PC00190 Huntington disease#P00029>Calpain#P00788 HUMAN|HGNC=4594|UniProtKB=Q14416 Q14416 GRM2 PTHR24060:SF147 METABOTROPIC GLUTAMATE RECEPTOR METABOTROPIC GLUTAMATE RECEPTOR 2 adenylate cyclase inhibiting G protein-coupled glutamate receptor activity#GO:0001640;glutamate receptor activity#GO:0008066;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;regulation of synaptic transmission, glutamatergic#GO:0051966;glutamate receptor signaling pathway#GO:0007215;G protein-coupled receptor signaling pathway#GO:0007186;regulation of signaling#GO:0023051;regulation of trans-synaptic signaling#GO:0099177;biological regulation#GO:0065007;signal transduction#GO:0007165;cellular process#GO:0009987;cell surface receptor signaling pathway#GO:0007166 G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GoPCR#P00725;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;Ionotropic glutamate receptor pathway#P00037>mGluR 2/3#P01014;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GqPCR#P00730;Metabotropic glutamate receptor group II pathway#P00040>mGluR2/3#P01048 HUMAN|HGNC=21689|UniProtKB=Q9Y3D6 Q9Y3D6 FIS1 PTHR13247:SF0 TETRATRICOPEPTIDE REPEAT PROTEIN 11 TPR REPEAT PROTEIN 11 MITOCHONDRIAL FISSION 1 PROTEIN lipid binding#GO:0008289;binding#GO:0005488 mitochondrion organization#GO:0007005;mitochondrial fission#GO:0000266;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;organelle fission#GO:0048285;cellular component organization or biogenesis#GO:0071840;peroxisome organization#GO:0007031 mitochondrial outer membrane#GO:0005741;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;peroxisomal membrane#GO:0005778;organelle outer membrane#GO:0031968;cytoplasm#GO:0005737;membrane#GO:0016020;mitochondrial membrane#GO:0031966;microbody#GO:0042579;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;outer membrane#GO:0019867;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;peroxisome#GO:0005777;mitochondrion#GO:0005739 HUMAN|HGNC=13945|UniProtKB=Q9Y4H4 Q9Y4H4 GPSM3 PTHR47617:SF1 G-PROTEIN SIGNALING MODULATOR 3 G PROTEIN-SIGNALING MODULATOR 3 positive regulation of response to external stimulus#GO:0032103;positive regulation of defense response#GO:0031349;regulation of defense response#GO:0031347;regulation of response to stimulus#GO:0048583;regulation of inflammatory response#GO:0050727;positive regulation of inflammatory response#GO:0050729;regulation of response to stress#GO:0080134;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;regulation of response to external stimulus#GO:0032101;positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789 HUMAN|HGNC=7887|UniProtKB=Q9UNW9 Q9UNW9 NOVA2 PTHR10288:SF162 KH DOMAIN CONTAINING RNA BINDING PROTEIN RNA-BINDING PROTEIN NOVA-2 mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 regulation of alternative mRNA splicing, via spliceosome#GO:0000381;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;mRNA metabolic process#GO:0016071;regulation of biological process#GO:0050789;mRNA splicing, via spliceosome#GO:0000398;regulation of mRNA metabolic process#GO:1903311;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;mRNA processing#GO:0006397;regulation of RNA metabolic process#GO:0051252;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA splicing, via transesterification reactions#GO:0000375;RNA biosynthetic process#GO:0032774;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of mRNA splicing, via spliceosome#GO:0048024;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;regulation of RNA splicing#GO:0043484;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of mRNA processing#GO:0050684;macromolecule biosynthetic process#GO:0009059;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031 HUMAN|HGNC=5233|UniProtKB=P0DMV9 P0DMV9 HSPA1B PTHR19375:SF223 HEAT SHOCK PROTEIN 70KDA HEAT SHOCK 70 KDA PROTEIN 1A-RELATED protein binding#GO:0005515;hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;ATP-dependent activity#GO:0140657;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;heat shock protein binding#GO:0031072;hydrolase activity, acting on acid anhydrides#GO:0016817 regulation of ubiquitin-dependent protein catabolic process#GO:2000058;metabolic process#GO:0008152;regulation of protein metabolic process#GO:0051246;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;protein maturation#GO:0051604;gene expression#GO:0010467;regulation of proteasomal protein catabolic process#GO:0061136;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032436;positive regulation of protein metabolic process#GO:0051247;positive regulation of metabolic process#GO:0009893;protein refolding#GO:0042026;positive regulation of proteasomal protein catabolic process#GO:1901800;regulation of biological process#GO:0050789;protein folding#GO:0006457;positive regulation of catabolic process#GO:0009896;macromolecule metabolic process#GO:0043170;regulation of catabolic process#GO:0009894;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;macromolecule biosynthetic process#GO:0009059;positive regulation of cellular process#GO:0048522;biosynthetic process#GO:0009058;biological regulation#GO:0065007;protein metabolic process#GO:0019538;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434;regulation of protein catabolic process#GO:0042176;positive regulation of protein catabolic process#GO:0045732;primary metabolic process#GO:0044238;positive regulation of ubiquitin-dependent protein catabolic process#GO:2000060;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cytosol#GO:0005829;nucleus#GO:0005634 Hsp70 family chaperone#PC00027;chaperone#PC00072 Apoptosis signaling pathway#P00006>HSP70#P00321;Parkinson disease#P00049>Hsp70#P01208;Gonadotropin-releasing hormone receptor pathway#P06664>miR-132/212#G06683 HUMAN|HGNC=26624|UniProtKB=Q8NAX2 Q8NAX2 KDF1 PTHR35085:SF1 KERATINOCYTE DIFFERENTIATION FACTOR 1 KERATINOCYTE DIFFERENTIATION FACTOR 1 regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of cell division#GO:0051302;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;cell junction#GO:0030054 HUMAN|HGNC=6544|UniProtKB=P07864 P07864 LDHC PTHR43128:SF5 L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+)) L-LACTATE DEHYDROGENASE C CHAIN oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824 energy derivation by oxidation of organic compounds#GO:0015980;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;generation of precursor metabolites and energy#GO:0006091;monocarboxylic acid catabolic process#GO:0072329;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;small molecule catabolic process#GO:0044282;pyruvate metabolic process#GO:0006090;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395 9+2 motile cilium#GO:0097729;cilium#GO:0005929;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;sperm flagellum#GO:0036126;motile cilium#GO:0031514;organelle#GO:0043226 dehydrogenase#PC00092;oxidoreductase#PC00176 HUMAN|HGNC=22208|UniProtKB=Q8IVD9 Q8IVD9 NUDCD3 PTHR12356:SF19 NUCLEAR MOVEMENT PROTEIN NUDC NUDC DOMAIN-CONTAINING PROTEIN 3 primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;protein maturation#GO:0051604;protein folding#GO:0006457;biosynthetic process#GO:0009058;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 microtubule or microtubule-binding cytoskeletal protein#PC00157;cytoskeletal protein#PC00085 HUMAN|HGNC=37217|UniProtKB=C9J1S8 C9J1S8 TRIM49D1 PTHR24103:SF661 E3 UBIQUITIN-PROTEIN LIGASE TRIM TRIPARTITE MOTIF-CONTAINING PROTEIN 49D aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746 regulation of biological process#GO:0050789;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;immune system process#GO:0002376;defense response to symbiont#GO:0140546;immune response#GO:0006955;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;response to other organism#GO:0051707;defense response to other organism#GO:0098542;response to external stimulus#GO:0009605;defense response#GO:0006952;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;innate immune response#GO:0045087 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=32350|UniProtKB=A0PJX8 A0PJX8 TMEM82 PTHR35257:SF1 TRANSMEMBRANE PROTEIN 82 TRANSMEMBRANE PROTEIN 82 HUMAN|HGNC=8840|UniProtKB=P12955 P12955 PEPD PTHR43226:SF1 XAA-PRO AMINOPEPTIDASE 3 XAA-PRO DIPEPTIDASE catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233 cellular process#GO:0009987;proteolysis#GO:0006508;metabolic process#GO:0008152;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 metalloprotease#PC00153 HUMAN|HGNC=26940|UniProtKB=Q9UI30 Q9UI30 TRMT112 PTHR12773:SF0 UPF0315 PROTEIN-RELATED MULTIFUNCTIONAL METHYLTRANSFERASE SUBUNIT TRM112-LIKE PROTEIN molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;enzyme activator activity#GO:0008047 RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;ribosome biogenesis#GO:0042254;ribosomal large subunit biogenesis#GO:0042273;nucleic acid biosynthetic process#GO:0141187;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;ribosomal small subunit biogenesis#GO:0042274;maturation of LSU-rRNA#GO:0000470;gene expression#GO:0010467;RNA processing#GO:0006396;biosynthetic process#GO:0009058;maturation of SSU-rRNA#GO:0030490;nucleobase-containing compound metabolic process#GO:0006139;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;methyltransferase complex#GO:0034708;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=5363|UniProtKB=P47928 P47928 ID4 PTHR11723:SF6 DNA-BINDING PROTEIN INHIBITOR DNA-BINDING PROTEIN INHIBITOR ID-4 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714 regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;system development#GO:0048731;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;negative regulation of metabolic process#GO:0009892;neuron differentiation#GO:0030182;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;multicellular organism development#GO:0007275;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;nervous system development#GO:0007399 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 HUMAN|HGNC=26435|UniProtKB=Q96NB1 Q96NB1 CEP20 PTHR15431:SF21 FGFR1 ONCOGENE PARTNER/LISH DOMAIN-CONTAINING PROTEIN CENTROSOMAL PROTEIN 20 cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component organization#GO:0016043;cilium assembly#GO:0060271;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cell projection organization#GO:0030030;organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031;cilium organization#GO:0044782;cellular component organization or biogenesis#GO:0071840 microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;centrosome#GO:0005813;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;ciliary basal body#GO:0036064;membraneless organelle#GO:0043228;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;motile cilium#GO:0031514;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cilium#GO:0005929;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=14553|UniProtKB=Q7Z4F1 Q7Z4F1 LRP10 PTHR24270:SF17 LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 10 cargo receptor activity#GO:0038024;low-density lipoprotein particle receptor activity#GO:0005041 lipid localization#GO:0010876;macromolecule localization#GO:0033036;transport#GO:0006810;lipid transport#GO:0006869;localization#GO:0051179;establishment of localization#GO:0051234 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 apolipoprotein#PC00052;transfer/carrier protein#PC00219 HUMAN|HGNC=25121|UniProtKB=Q69YL0 Q69YL0 NCBP2AS2 PTHR41161:SF1 PROTEIN NCBP2AS2 PROTEIN NCBP2AS2 HUMAN|HGNC=225|UniProtKB=P55265 P55265 ADAR PTHR10910:SF107 EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN DOUBLE-STRANDED RNA-SPECIFIC ADENOSINE DEAMINASE double-stranded RNA binding#GO:0003725;tRNA-specific adenosine deaminase activity#GO:0008251;nucleic acid binding#GO:0003676;binding#GO:0005488;adenosine deaminase activity#GO:0004000;catalytic activity, acting on a tRNA#GO:0140101;hydrolase activity#GO:0016787;RNA binding#GO:0003723;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;deaminase activity#GO:0019239;catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;adenosine to inosine editing#GO:0006382;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187;base conversion or substitution editing#GO:0016553;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070 nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232 RNA metabolism protein#PC00031 HUMAN|HGNC=31973|UniProtKB=A8MQT2 A8MQT2 GOLGA8B PTHR10881:SF63 GOLGIN SUBFAMILY A MEMBER-RELATED GOLGIN SUBFAMILY A MEMBER 8B endomembrane system organization#GO:0010256;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;Golgi organization#GO:0007030;cellular component organization#GO:0016043;organelle organization#GO:0006996 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;Golgi stack#GO:0005795;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;Golgi cis cisterna#GO:0000137;cytoplasm#GO:0005737;Golgi cisterna#GO:0031985;endomembrane system#GO:0012505;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;cis-Golgi network#GO:0005801;organelle membrane#GO:0031090;Golgi apparatus#GO:0005794 membrane traffic protein#PC00150 HUMAN|HGNC=8494|UniProtKB=Q9Y226 Q9Y226 SLC22A13 PTHR24064:SF705 SOLUTE CARRIER FAMILY 22 MEMBER SOLUTE CARRIER FAMILY 22 MEMBER 13 carboxylic acid transmembrane transporter activity#GO:0046943;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monocarboxylic acid transmembrane transporter activity#GO:0008028 monocarboxylic acid transport#GO:0015718;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;transport#GO:0006810;carboxylic acid transport#GO:0046942;organic acid transport#GO:0015849;cellular process#GO:0009987;nitrogen compound transport#GO:0071705 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 secondary carrier transporter#PC00258 HUMAN|HGNC=18178|UniProtKB=Q9UK41 Q9UK41 VPS28 PTHR12937:SF0 VACUOLAR PROTEIN SORTING 28, ISOFORM 2 VPS28 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 28 HOMOLOG protein binding#GO:0005515;ubiquitin binding#GO:0043130;binding#GO:0005488 cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;intracellular protein transport#GO:0006886;endosomal transport#GO:0016197;establishment of protein localization to vacuole#GO:0072666;protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043328;late endosome to vacuole transport#GO:0045324;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;cellular localization#GO:0051641;protein transport#GO:0015031;macromolecule localization#GO:0033036;multivesicular body sorting pathway#GO:0071985;late endosome to vacuole transport via multivesicular body sorting pathway#GO:0032511;ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043162;endosome transport via multivesicular body sorting pathway#GO:0032509;intracellular transport#GO:0046907;transport#GO:0006810;vacuolar transport#GO:0007034;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;establishment of protein localization to organelle#GO:0072594;ubiquitin-dependent protein catabolic process#GO:0006511;intracellular protein localization#GO:0008104;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;protein localization to organelle#GO:0033365;catabolic process#GO:0009056;protein localization to vacuole#GO:0072665;protein metabolic process#GO:0019538;localization#GO:0051179 organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;ESCRT I complex#GO:0000813;membrane#GO:0016020;vesicle membrane#GO:0012506;cytosol#GO:0005829;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;endosome#GO:0005768;endosome membrane#GO:0010008;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;vesicle#GO:0031982;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 membrane traffic protein#PC00150 HUMAN|HGNC=18907|UniProtKB=Q9BYQ7 Q9BYQ7 KRTAP4-1 PTHR23262:SF208 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 4-1 multicellular organismal process#GO:0032501 structural protein#PC00211 HUMAN|HGNC=71|UniProtKB=Q9UG63 Q9UG63 ABCF2 PTHR19211:SF15 ATP-BINDING TRANSPORT PROTEIN-RELATED ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2 small molecule binding#GO:0036094;anion binding#GO:0043168;binding#GO:0005488;ATP binding#GO:0005524;nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167;ribonucleotide binding#GO:0032553;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;carbohydrate derivative binding#GO:0097367;nucleotide binding#GO:0000166;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555 translation elongation factor#PC00222 HUMAN|HGNC=3363|UniProtKB=P49961 P49961 ENTPD1 PTHR11782:SF32 ADENOSINE/GUANOSINE DIPHOSPHATASE ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 1 hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleoside diphosphate phosphatase activity#GO:0017110;hydrolase activity#GO:0016787 nucleobase-containing compound catabolic process#GO:0034655;organophosphate metabolic process#GO:0019637;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;cellular process#GO:0009987;nucleoside diphosphate catabolic process#GO:0009134;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;nucleoside phosphate catabolic process#GO:1901292;nucleobase-containing compound metabolic process#GO:0006139;nucleoside phosphate metabolic process#GO:0006753;metabolic process#GO:0008152;nucleoside diphosphate metabolic process#GO:0009132;organophosphate catabolic process#GO:0046434;nucleobase-containing small molecule metabolic process#GO:0055086 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 phosphatase#PC00181;nucleotide phosphatase#PC00173;hydrolase#PC00121 HUMAN|HGNC=33741|UniProtKB=Q6ZTZ1 Q6ZTZ1 MSANTD1 PTHR22666:SF3 MYB_SANT-LIKE DNA-BINDING DOMAIN-CONTAINING PROTEIN 1 MYB_SANT-LIKE DNA-BINDING DOMAIN-CONTAINING PROTEIN 1 regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nuclear body#GO:0016604;intracellular membraneless organelle#GO:0043232;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=10983|UniProtKB=Q9UJS0 Q9UJS0 SLC25A13 PTHR45678:SF12 MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED ELECTROGENIC ASPARTATE_GLUTAMATE ANTIPORTER SLC25A13, MITOCHONDRIAL carboxylic acid transmembrane transporter activity#GO:0046943;C4-dicarboxylate transmembrane transporter activity#GO:0015556;acidic amino acid transmembrane transporter activity#GO:0015172;L-amino acid transmembrane transporter activity#GO:0015179;dicarboxylic acid transmembrane transporter activity#GO:0005310;L-glutamate transmembrane transporter activity#GO:0005313;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;amino acid transmembrane transporter activity#GO:0015171 nucleobase-containing small molecule metabolic process#GO:0055086;organic acid transport#GO:0015849;amino acid transport#GO:0006865;carboxylic acid transport#GO:0046942;acidic amino acid transport#GO:0015800;metabolic process#GO:0008152;L-glutamate transmembrane transport#GO:0015813;cellular process#GO:0009987;nicotinamide nucleotide metabolic process#GO:0046496;transmembrane transport#GO:0055085;nucleotide metabolic process#GO:0009117;small molecule metabolic process#GO:0044281;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;phosphorus metabolic process#GO:0006793;establishment of localization#GO:0051234;C4-dicarboxylate transport#GO:0015740;transport#GO:0006810;dicarboxylic acid transport#GO:0006835;nucleobase-containing compound metabolic process#GO:0006139;nitrogen compound transport#GO:0071705;L-amino acid transport#GO:0015807;NAD+ metabolic process#GO:0019674;organophosphate metabolic process#GO:0019637;aspartate transmembrane transport#GO:0015810;amino acid transmembrane transport#GO:0003333;localization#GO:0051179;L-glutamate import#GO:0051938;pyridine-containing compound metabolic process#GO:0072524;carboxylic acid transmembrane transport#GO:1905039;nucleoside phosphate metabolic process#GO:0006753;primary metabolic process#GO:0044238;L-alpha-amino acid transmembrane transport#GO:1902475 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 secondary carrier transporter#PC00258;transporter#PC00227 HUMAN|HGNC=31351|UniProtKB=P0C7Q6 P0C7Q6 SLC35G6 PTHR22911:SF110 ACYL-MALONYL CONDENSING ENZYME-RELATED SOLUTE CARRIER FAMILY 35 MEMBER G3-RELATED membrane#GO:0016020;cellular anatomical structure#GO:0110165 transporter#PC00227 HUMAN|Gene=OVOS1|UniProtKB=Q6IE37 Q6IE37 OVOS1 PTHR11412:SF174 MACROGLOBULIN / COMPLEMENT OVOSTATIN HOMOLOG 1-RELATED molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866;enzyme inhibitor activity#GO:0004857;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;peptidase regulator activity#GO:0061134;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414 defense response#GO:0006952;response to stimulus#GO:0050896;inflammatory response#GO:0006954;response to stress#GO:0006950 extracellular region#GO:0005576;extracellular protein-containing complex#GO:0140392;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 protease inhibitor#PC00191 HUMAN|HGNC=15093|UniProtKB=Q8NGT5 Q8NGT5 OR9A2 PTHR24242:SF248 G-PROTEIN COUPLED RECEPTOR OLFACTORY RECEPTOR 9A2 G-protein coupled receptor#PC00021 HUMAN|HGNC=29634|UniProtKB=Q96KG7 Q96KG7 MEGF10 PTHR24035:SF136 MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN 10 protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 cellular component organization or biogenesis#GO:0071840;phagocytosis, engulfment#GO:0006911;localization#GO:0051179;apoptotic cell clearance#GO:0043277;import into cell#GO:0098657;establishment of localization#GO:0051234;phagocytosis#GO:0006909;membrane invagination#GO:0010324;transport#GO:0006810;endocytosis#GO:0006897;cell motility#GO:0048870;cell migration#GO:0016477;membrane organization#GO:0061024;cellular component organization#GO:0016043;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 extracellular matrix protein#PC00102 HUMAN|HGNC=17175|UniProtKB=Q9P212 Q9P212 PLCE1 PTHR10336:SF6 PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN 1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1 phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578;phospholipase activity#GO:0120569;hydrolase activity, acting on ester bonds#GO:0016788;glycerophospholipase activity#GO:0004620;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;lipase activity#GO:0016298 cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;metal ion transport#GO:0030001;phospholipid metabolic process#GO:0006644;regulation of cellular process#GO:0050794;Ras protein signal transduction#GO:0007265;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;localization#GO:0051179;monoatomic cation transport#GO:0006812;organophosphate metabolic process#GO:0019637;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;monoatomic ion transmembrane transport#GO:0034220;lipid metabolic process#GO:0006629;transport#GO:0006810;phosphatidylinositol metabolic process#GO:0046488;establishment of localization#GO:0051234;regulation of biological process#GO:0050789;calcium ion transmembrane transport#GO:0070588;phosphorus metabolic process#GO:0006793;signaling#GO:0023052;glycerolipid metabolic process#GO:0046486;response to stimulus#GO:0050896;G protein-coupled receptor signaling pathway#GO:0007186;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;signal transduction#GO:0007165;release of sequestered calcium ion into cytosol#GO:0051209;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;intracellular signaling cassette#GO:0141124;glycerophospholipid metabolic process#GO:0006650;metabolic process#GO:0008152;calcium ion transport#GO:0006816;calcium ion transmembrane import into cytosol#GO:0097553 lipase#PC00143;phospholipase#PC00186;metabolite interconversion enzyme#PC00262;hydrolase#PC00121 Oxytocin receptor mediated signaling pathway#P04391>PLC beta#P04530;Histamine H1 receptor mediated signaling pathway#P04385>PLC#P04484;5HT2 type receptor mediated signaling pathway#P04374>PLC#P04412;Alpha adrenergic receptor signaling pathway#P00002>PLC#P00073;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PLCbetagamma#P00874;Thyrotropin-releasing hormone receptor signaling pathway#P04394>PLC#P04581 HUMAN|HGNC=23613|UniProtKB=Q86UG4 Q86UG4 SLCO6A1 PTHR11388:SF95 ORGANIC ANION TRANSPORTER SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 6A1 active transmembrane transporter activity#GO:0022804;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 cellular process#GO:0009987;transport#GO:0006810;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179 basal plasma membrane#GO:0009925;cell periphery#GO:0071944;basal part of cell#GO:0045178;basolateral plasma membrane#GO:0016323;membrane#GO:0016020;plasma membrane#GO:0005886;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165 transporter#PC00227 HUMAN|HGNC=26554|UniProtKB=Q96M29 Q96M29 TEKT5 PTHR19960:SF23 TEKTIN TEKTIN-5 cellular component organization#GO:0016043;cilium assembly#GO:0060271;microtubule-based movement#GO:0007018;cell motility#GO:0048870;cell projection organization#GO:0030030;organelle assembly#GO:0070925;cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;cilium-dependent cell motility#GO:0060285;cilium organization#GO:0044782;cilium movement involved in cell motility#GO:0060294;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;plasma membrane bounded cell projection assembly#GO:0120031;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017 plasma membrane bounded cell projection#GO:0120025;intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;sperm flagellum#GO:0036126;motile cilium#GO:0031514;organelle#GO:0043226;microtubule cytoskeleton#GO:0015630;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;cilium#GO:0005929;9+2 motile cilium#GO:0097729;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 microtubule or microtubule-binding cytoskeletal protein#PC00157;non-motor microtubule binding protein#PC00166 HUMAN|HGNC=5633|UniProtKB=A0A075B7D8 A0A075B7D8 IGHV3OR15-7 PTHR23266:SF346 IMMUNOGLOBULIN HEAVY CHAIN IG-LIKE DOMAIN-CONTAINING PROTEIN antigen binding#GO:0003823;binding#GO:0005488 immune system process#GO:0002376;immune effector process#GO:0002252;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;immune response#GO:0006955;response to stimulus#GO:0050896;adaptive immune response#GO:0002250 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=26286|UniProtKB=Q5FYB0 Q5FYB0 ARSJ PTHR10342:SF69 ARYLSULFATASE ARYLSULFATASE J catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787 HUMAN|HGNC=25450|UniProtKB=Q9P2F5 Q9P2F5 STOX2 PTHR22437:SF2 WINGED HELIX DOMAIN-CONTAINING PROTEIN STORKHEAD-BOX PROTEIN 2 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=13723|UniProtKB=P49711 P49711 CTCF PTHR24404:SF43 ZINC FINGER PROTEIN TRANSCRIPTIONAL REPRESSOR CTCF double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218 HUMAN|HGNC=10963|UniProtKB=O15245 O15245 SLC22A1 PTHR24064:SF291 SOLUTE CARRIER FAMILY 22 MEMBER SOLUTE CARRIER FAMILY 22 MEMBER 1 quaternary ammonium group transmembrane transporter activity#GO:0015651;monoamine transmembrane transporter activity#GO:0008504;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;active transmembrane transporter activity#GO:0022804 organic hydroxy compound transport#GO:0015850;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810;cellular process#GO:0009987;quaternary ammonium group transport#GO:0015697;nitrogen compound transport#GO:0071705 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 secondary carrier transporter#PC00258 HUMAN|HGNC=11632|UniProtKB=O43680 O43680 TCF21 PTHR23349:SF67 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST TRANSCRIPTION FACTOR 21 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 basic helix-loop-helix transcription factor#PC00055;DNA-binding transcription factor#PC00218 HUMAN|HGNC=12619|UniProtKB=Q9Y2K6 Q9Y2K6 USP20 PTHR21646:SF13 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 20 peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;cysteine-type deubiquitinase activity#GO:0004843;cysteine-type peptidase activity#GO:0008234;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005 multicellular organism development#GO:0007275;developmental process#GO:0032502;regulation of G protein-coupled receptor signaling pathway#GO:0008277;regulation of response to stimulus#GO:0048583;multicellular organismal process#GO:0032501;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;nervous system development#GO:0007399;regulation of protein stability#GO:0031647;anatomical structure development#GO:0048856;system development#GO:0048731;regulation of biological quality#GO:0065008;animal gross anatomical part developmental process#GO:0160108;regulation of signaling#GO:0023051;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of biological process#GO:0050789 cysteine protease#PC00081 HUMAN|HGNC=26245|UniProtKB=A8MT70 A8MT70 ZBBX PTHR28634:SF1 ZINC FINGER B-BOX DOMAIN-CONTAINING PROTEIN 1 ZINC FINGER B-BOX DOMAIN-CONTAINING PROTEIN 1 HUMAN|HGNC=8133|UniProtKB=P78380 P78380 OLR1 PTHR47298:SF1 OXIDIZED LOW-DENSITY LIPOPROTEIN RECEPTOR 1 OXIDIZED LOW-DENSITY LIPOPROTEIN RECEPTOR 1 low-density lipoprotein particle receptor activity#GO:0005041;cargo receptor activity#GO:0038024 metabolic process#GO:0008152;cell adhesion#GO:0007155;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;cell-cell adhesion#GO:0098609;leukocyte cell-cell adhesion#GO:0007159;cellular process#GO:0009987;lipoprotein metabolic process#GO:0042157 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane#GO:0016020;signaling receptor complex#GO:0043235;cell periphery#GO:0071944 HUMAN|HGNC=1057|UniProtKB=P51451 P51451 BLK PTHR24418:SF181 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE BLK protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;signaling receptor binding#GO:0005102;binding#GO:0005488;non-membrane spanning protein tyrosine kinase activity#GO:0004715;protein binding#GO:0005515;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cell differentiation#GO:0030154;signaling#GO:0023052;biological regulation#GO:0065007;cell surface receptor signaling pathway#GO:0007166;developmental process#GO:0032502;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;enzyme-linked receptor protein signaling pathway#GO:0007167;cellular developmental process#GO:0048869;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 non-receptor tyrosine protein kinase#PC00168 Parkinson disease#P00049>Src kinase#P01230;B cell activation#P00010>Blk#P00390 HUMAN|HGNC=11058|UniProtKB=Q9NS82 Q9NS82 SLC7A10 PTHR11785:SF73 AMINO ACID TRANSPORTER ASC-TYPE AMINO ACID TRANSPORTER 1 L-amino acid transmembrane transporter activity#GO:0015179;amino acid transmembrane transporter activity#GO:0015171;neutral L-amino acid transmembrane transporter activity#GO:0015175;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;carboxylic acid transmembrane transporter activity#GO:0046943 nitrogen compound transport#GO:0071705;cellular process#GO:0009987;carboxylic acid transmembrane transport#GO:1905039;alanine transport#GO:0032328;transport#GO:0006810;carboxylic acid transport#GO:0046942;organic acid transport#GO:0015849;amino acid transport#GO:0006865;localization#GO:0051179;establishment of localization#GO:0051234;neutral amino acid transport#GO:0015804;transmembrane transport#GO:0055085;amino acid transmembrane transport#GO:0003333 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227 HUMAN|HGNC=23502|UniProtKB=Q8IW52 Q8IW52 SLITRK4 PTHR45773:SF3 SLIT AND NTRK-LIKE PROTEIN 4-RELATED SLIT AND NTRK-LIKE PROTEIN 4 cellular component organization#GO:0016043;regulation of multicellular organismal development#GO:2000026;positive regulation of multicellular organismal process#GO:0051240;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;cell morphogenesis#GO:0000902;regulation of cellular component organization#GO:0051128;cell differentiation#GO:0030154;positive regulation of nervous system development#GO:0051962;cell projection organization#GO:0030030;regulation of cellular component biogenesis#GO:0044087;cell development#GO:0048468;animal gross anatomical part developmental process#GO:0160108;regulation of synapse organization#GO:0050807;positive regulation of cellular component organization#GO:0051130;generation of neurons#GO:0048699;neuron development#GO:0048666;axonogenesis#GO:0007409;regulation of biological quality#GO:0065008;neuron projection development#GO:0031175;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of cellular component biogenesis#GO:0044089;nervous system development#GO:0007399;regulation of multicellular organismal process#GO:0051239;cell morphogenesis involved in neuron differentiation#GO:0048667;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cell projection morphogenesis#GO:0048858;regulation of cellular process#GO:0050794;regulation of developmental process#GO:0050793;regulation of cell junction assembly#GO:1901888;anatomical structure development#GO:0048856;regulation of synapse structure or activity#GO:0050803;regulation of nervous system development#GO:0051960;system development#GO:0048731;axon development#GO:0061564;positive regulation of cellular process#GO:0048522;multicellular organismal process#GO:0032501;regulation of synapse assembly#GO:0051963;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;positive regulation of developmental process#GO:0051094;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;positive regulation of synapse assembly#GO:0051965 synapse#GO:0045202;cellular anatomical structure#GO:0110165;glutamatergic synapse#GO:0098978;cell junction#GO:0030054 transmembrane signal receptor#PC00197 HUMAN|HGNC=7056|UniProtKB=O60502 O60502 OGA PTHR13170:SF16 O-GLCNACASE PROTEIN O-GLCNACASE hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 hydrolase#PC00121 HUMAN|HGNC=1737|UniProtKB=Q5VT25 Q5VT25 CDC42BPA PTHR22988:SF31 MYOTONIC DYSTROPHY S/T KINASE-RELATED SERINE_THREONINE-PROTEIN KINASE MRCK ALPHA protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096 actin filament-based process#GO:0030029;cellular component organization or biogenesis#GO:0071840;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;actin cytoskeleton organization#GO:0030036;cytoskeleton organization#GO:0007010;actomyosin structure organization#GO:0031032 actomyosin#GO:0042641;actin cytoskeleton#GO:0015629;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=16037|UniProtKB=Q53FV1 Q53FV1 ORMDL2 PTHR12665:SF13 ORMDL PROTEINS ORM1-LIKE PROTEIN 2 homeostatic process#GO:0042592;primary metabolic process#GO:0044238;lipid homeostasis#GO:0055088;cellular process#GO:0009987;ceramide metabolic process#GO:0006672;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;chemical homeostasis#GO:0048878 protein-containing complex#GO:0032991;catalytic complex#GO:1902494;transferase complex#GO:1990234 HUMAN|HGNC=21641|UniProtKB=O95859 O95859 TSPAN12 PTHR19282:SF462 TETRASPANIN TETRASPANIN-12 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HUMAN|HGNC=27729|UniProtKB=Q495C1 Q495C1 RNF212 PTHR22663:SF21 RING FINGER PROTEIN NARYA-RELATED E3 SUMO-PROTEIN LIGASE RNF212-RELATED SUMO transferase activity#GO:0019789;ubiquitin-like protein transferase activity#GO:0019787;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 organelle fission#GO:0048285;nuclear division#GO:0000280;meiosis I cell cycle process#GO:0061982;sexual reproduction#GO:0019953;reproductive process#GO:0022414;meiosis I#GO:0007127;cellular component organization#GO:0016043;meiotic cell cycle process#GO:1903046;nuclear chromosome segregation#GO:0098813;cell cycle#GO:0007049;cell cycle process#GO:0022402;meiotic nuclear division#GO:0140013;homologous chromosome segregation#GO:0045143;cellular component organization or biogenesis#GO:0071840;meiotic chromosome segregation#GO:0045132;chromosome organization#GO:0051276;chromosome organization involved in meiotic cell cycle#GO:0070192;meiotic cell cycle#GO:0051321;chromosome segregation#GO:0007059;homologous chromosome pairing at meiosis#GO:0007129;organelle organization#GO:0006996;cellular process#GO:0009987 condensed chromosome#GO:0000793;membraneless organelle#GO:0043228;condensed nuclear chromosome#GO:0000794;synaptonemal complex#GO:0000795;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;synaptonemal structure#GO:0099086;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;chromosome#GO:0005694;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=14373|UniProtKB=Q92990 Q92990 GLMN PTHR15430:SF2 GLOMULIN GLOMULIN enzyme inhibitor activity#GO:0004857;molecular function inhibitor activity#GO:0140678;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234 animal gross anatomical part developmental process#GO:0160108;anatomical structure development#GO:0048856;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434;regulation of protein catabolic process#GO:0042176;system development#GO:0048731;blood vessel morphogenesis#GO:0048514;blood vessel development#GO:0001568;tube morphogenesis#GO:0035239;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;regulation of cellular process#GO:0050794;circulatory system development#GO:0072359;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;developmental process#GO:0032502;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;regulation of catabolic process#GO:0009894;vasculature development#GO:0001944;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;multicellular organismal process#GO:0032501;vasculogenesis#GO:0001570;regulation of proteasomal protein catabolic process#GO:0061136;tube development#GO:0035295;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cullin-RING ubiquitin ligase complex#GO:0031461;cytoplasm#GO:0005737;ubiquitin ligase complex#GO:0000151;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;transferase complex#GO:1990234 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=17589|UniProtKB=Q8WV07 Q8WV07 LTO1 PTHR12900:SF6 MITOTIC AND DNA DAMAGE CHECKPOINT PROTEIN HUS1 PROTEIN LTO1 HOMOLOG telomere organization#GO:0032200;regulation of G2/M transition of mitotic cell cycle#GO:0010389;sexual reproduction#GO:0019953;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;cell cycle#GO:0007049;regulation of cell cycle phase transition#GO:1901987;chromosome organization#GO:0051276;mitotic cell cycle process#GO:1903047;macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;mitotic intra-S DNA damage checkpoint signaling#GO:0031573;regulation of cell cycle#GO:0051726;response to stimulus#GO:0050896;cell cycle process#GO:0022402;double-strand break repair via homologous recombination#GO:0000724;regulation of biological process#GO:0050789;signal transduction in response to DNA damage#GO:0042770;negative regulation of cell cycle phase transition#GO:1901988;negative regulation of biological process#GO:0048519;negative regulation of cell cycle G2/M phase transition#GO:1902750;cellular component organization or biogenesis#GO:0071840;DNA metabolic process#GO:0006259;meiotic cell cycle#GO:0051321;negative regulation of mitotic cell cycle phase transition#GO:1901991;cellular process#GO:0009987;signal transduction#GO:0007165;organelle organization#GO:0006996;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;recombinational repair#GO:0000725;reproductive process#GO:0022414;mitotic cell cycle#GO:0000278;mitotic DNA damage checkpoint signaling#GO:0044773;nucleic acid metabolic process#GO:0090304;mitotic cell cycle checkpoint signaling#GO:0007093;telomere maintenance#GO:0000723;negative regulation of cell cycle process#GO:0010948;DNA repair#GO:0006281;nucleobase-containing compound metabolic process#GO:0006139;DNA damage checkpoint signaling#GO:0000077;mitotic DNA integrity checkpoint signaling#GO:0044774;regulation of mitotic cell cycle#GO:0007346;mitotic G2/M transition checkpoint#GO:0044818;regulation of cell cycle G2/M phase transition#GO:1902749;DNA integrity checkpoint signaling#GO:0031570;negative regulation of mitotic cell cycle#GO:0045930;regulation of mitotic cell cycle phase transition#GO:1901990;cellular response to stress#GO:0033554;signaling#GO:0023052;mitotic DNA replication checkpoint signaling#GO:0033314;meiotic cell cycle process#GO:1903046;cellular component organization#GO:0016043;DNA replication checkpoint signaling#GO:0000076;double-strand break repair#GO:0006302;negative regulation of cell cycle#GO:0045786;DNA recombination#GO:0006310;metabolic process#GO:0008152;regulation of cell cycle process#GO:0010564;negative regulation of G2/M transition of mitotic cell cycle#GO:0010972;cell cycle checkpoint signaling#GO:0000075;response to stress#GO:0006950 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;site of DNA damage#GO:0090734;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;condensed chromosome#GO:0000793;nuclear protein-containing complex#GO:0140513;condensed nuclear chromosome#GO:0000794;membraneless organelle#GO:0043228;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;site of double-strand break#GO:0035861;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;protein-containing complex#GO:0032991 DNA metabolism protein#PC00009 HUMAN|HGNC=9103|UniProtKB=O43157 O43157 PLXNB1 PTHR22625:SF36 PLEXIN PLEXIN-B1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 positive regulation of cell development#GO:0010720;nervous system development#GO:0007399;regulation of multicellular organismal process#GO:0051239;cellular component assembly#GO:0022607;cellular process#GO:0009987;regulation of neuron projection development#GO:0010975;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular component biogenesis#GO:0044085;regulation of axonogenesis#GO:0050770;regulation of anatomical structure morphogenesis#GO:0022603;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;positive regulation of cell differentiation#GO:0045597;cell surface receptor signaling pathway#GO:0007166;signaling#GO:0023052;synapse assembly#GO:0007416;regulation of cellular component organization#GO:0051128;positive regulation of nervous system development#GO:0051962;response to stimulus#GO:0050896;regulation of cell shape#GO:0008360;regulation of multicellular organismal development#GO:2000026;positive regulation of multicellular organismal process#GO:0051240;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;cell junction assembly#GO:0034329;negative regulation of biological process#GO:0048519;regulation of biological quality#GO:0065008;positive regulation of axonogenesis#GO:0050772;positive regulation of cellular component organization#GO:0051130;animal gross anatomical part developmental process#GO:0160108;regulation of locomotion#GO:0040012;biological regulation#GO:0065007;regulation of cell adhesion#GO:0030155;multicellular organismal process#GO:0032501;negative regulation of cell adhesion#GO:0007162;regulation of cell development#GO:0060284;positive regulation of cellular process#GO:0048522;regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of cell differentiation#GO:0045595;regulation of cell migration#GO:0030334;positive regulation of developmental process#GO:0051094;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;regulation of cell projection organization#GO:0031344;positive regulation of neurogenesis#GO:0050769;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;cell junction organization#GO:0034330;cellular response to stimulus#GO:0051716;regulation of neurogenesis#GO:0050767;system development#GO:0048731;regulation of nervous system development#GO:0051960;anatomical structure development#GO:0048856;regulation of cell motility#GO:2000145;cell communication#GO:0007154;positive regulation of cell projection organization#GO:0031346;synapse organization#GO:0050808 membrane#GO:0016020;cell periphery#GO:0071944;signaling receptor complex#GO:0043235;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 Axon guidance mediated by semaphorins#P00007>plexinB1#P00328 HUMAN|HGNC=18904|UniProtKB=P0C5Y4 P0C5Y4 KRTAP1-4 PTHR23262:SF236 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 1-4 structural protein#PC00211 HUMAN|HGNC=21961|UniProtKB=Q6NSZ9 Q6NSZ9 ZSCAN25 PTHR23226:SF1 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 25 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987 regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=19231|UniProtKB=Q9NTU4 Q9NTU4 CATSPERZ PTHR42155:SF1 CATION CHANNEL SPERM-ASSOCIATED PROTEIN SUBUNIT ZETA CATION CHANNEL SPERM-ASSOCIATED AUXILIARY SUBUNIT ZETA cilium movement involved in cell motility#GO:0060294;cellular process#GO:0009987;developmental maturation#GO:0021700;male gamete generation#GO:0048232;sperm capacitation#GO:0048240;flagellated sperm motility#GO:0030317;developmental process#GO:0032502;spermatogenesis#GO:0007283;cell maturation#GO:0048469;cellular developmental process#GO:0048869;microtubule-based process#GO:0007017;developmental process involved in reproduction#GO:0003006;anatomical structure maturation#GO:0071695;germ cell development#GO:0007281;sperm motility#GO:0097722;cell differentiation#GO:0030154;microtubule-based movement#GO:0007018;gamete generation#GO:0007276;cell motility#GO:0048870;cellular process involved in reproduction in multicellular organism#GO:0022412;reproductive process#GO:0022414;cell development#GO:0048468;spermatid differentiation#GO:0048515;cilium movement#GO:0003341;sexual reproduction#GO:0019953;cilium or flagellum-dependent cell motility#GO:0001539;spermatid development#GO:0007286;cilium-dependent cell motility#GO:0060285;anatomical structure development#GO:0048856;multicellular organismal reproductive process#GO:0048609 transmembrane transporter complex#GO:1902495;membrane-bounded organelle#GO:0043227;9+2 motile cilium#GO:0097729;cilium#GO:0005929;motile cilium#GO:0031514;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;membrane protein complex#GO:0098796;voltage-gated calcium channel complex#GO:0005891;calcium channel complex#GO:0034704;plasma membrane protein complex#GO:0098797;sperm principal piece#GO:0097228;transporter complex#GO:1990351;cation channel complex#GO:0034703;protein-containing complex#GO:0032991;CatSper complex#GO:0036128;monoatomic ion channel complex#GO:0034702;sperm flagellum#GO:0036126;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 ion channel#PC00133;transporter#PC00227 HUMAN|HGNC=1392|UniProtKB=Q15878 Q15878 CACNA1E PTHR45628:SF5 VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1 VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1E gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;voltage-gated channel activity#GO:0022832;transporter activity#GO:0005215;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;voltage-gated calcium channel activity#GO:0005245;calcium channel activity#GO:0005262;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261 transport#GO:0006810;establishment of localization#GO:0051234;import into cell#GO:0098657;calcium ion transmembrane import into cytosol#GO:0097553;inorganic cation import across plasma membrane#GO:0098659;calcium ion transport#GO:0006816;synaptic signaling#GO:0099536;cellular process#GO:0009987;biological regulation#GO:0065007;monoatomic cation transmembrane transport#GO:0098655;cell-cell signaling#GO:0007267;monoatomic ion transmembrane transport#GO:0034220;trans-synaptic signaling#GO:0099537;localization#GO:0051179;cell communication#GO:0007154;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;calcium ion transmembrane transport#GO:0070588;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;calcium ion import#GO:0070509;anterograde trans-synaptic signaling#GO:0098916;import across plasma membrane#GO:0098739;signaling#GO:0023052;metal ion transport#GO:0030001;inorganic ion import across plasma membrane#GO:0099587 transmembrane transporter complex#GO:1902495;membrane protein complex#GO:0098796;voltage-gated calcium channel complex#GO:0005891;calcium channel complex#GO:0034704;cell body#GO:0044297;plasma membrane protein complex#GO:0098797;cellular anatomical structure#GO:0110165;neuronal cell body#GO:0043025;cation channel complex#GO:0034703;transporter complex#GO:1990351;membrane#GO:0016020;cell periphery#GO:0071944;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477 voltage-gated ion channel#PC00241 Ionotropic glutamate receptor pathway#P00037>Ca2+ channel#P01022;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Ca2+channel#P00742;Metabotropic glutamate receptor group II pathway#P00040>Ca2+#P01051;Thyrotropin-releasing hormone receptor signaling pathway#P04394>Ca2+ channel#P04587;Metabotropic glutamate receptor group III pathway#P00039>Ca2+#P01041 HUMAN|HGNC=24050|UniProtKB=Q8IUR6 Q8IUR6 CREBRF PTHR21552:SF2 ADULT RETINA PROTEIN CREB3 REGULATORY FACTOR DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=10637|UniProtKB=P02778 P02778 CXCL10 PTHR12015:SF188 SMALL INDUCIBLE CYTOKINE A C-X-C MOTIF CHEMOKINE 10 molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;chemokine activity#GO:0008009;G protein-coupled receptor binding#GO:0001664;protein binding#GO:0005515;chemokine receptor binding#GO:0042379;molecular function activator activity#GO:0140677;signaling receptor binding#GO:0005102;cytokine receptor binding#GO:0005126;binding#GO:0005488;cytokine activity#GO:0005125 cell migration#GO:0016477;biological regulation#GO:0065007;response to other organism#GO:0051707;cellular response to molecule of bacterial origin#GO:0071219;response to external stimulus#GO:0009605;myeloid leukocyte migration#GO:0097529;leukocyte chemotaxis#GO:0030595;defense response#GO:0006952;leukocyte migration#GO:0050900;cell motility#GO:0048870;regulation of cellular process#GO:0050794;response to external biotic stimulus#GO:0043207;cellular response to chemokine#GO:1990869;locomotion#GO:0040011;cellular response to biotic stimulus#GO:0071216;cellular response to stimulus#GO:0051716;chemokine-mediated signaling pathway#GO:0070098;cell communication#GO:0007154;cell chemotaxis#GO:0060326;response to bacterium#GO:0009617;cytokine-mediated signaling pathway#GO:0019221;inflammatory response#GO:0006954;chemotaxis#GO:0006935;neutrophil migration#GO:1990266;taxis#GO:0042330;response to cytokine#GO:0034097;response to chemical#GO:0042221;granulocyte migration#GO:0097530;response to lipid#GO:0033993;cellular response to lipid#GO:0071396;response to chemokine#GO:1990868;response to biotic stimulus#GO:0009607;cellular response to lipopolysaccharide#GO:0071222;response to stress#GO:0006950;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;cellular process#GO:0009987;response to lipopolysaccharide#GO:0032496;neutrophil chemotaxis#GO:0030593;cell surface receptor signaling pathway#GO:0007166;granulocyte chemotaxis#GO:0071621;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052;regulation of biological process#GO:0050789;response to molecule of bacterial origin#GO:0002237;cellular response to cytokine stimulus#GO:0071345;response to peptide#GO:1901652;G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887;immune system process#GO:0002376;response to oxygen-containing compound#GO:1901700 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 cytokine#PC00083 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CHK#P00856 HUMAN|HGNC=17372|UniProtKB=Q9NZ32 Q9NZ32 ACTR10 PTHR11937:SF14 ACTIN ACTIN-RELATED PROTEIN 10 structural constituent of cytoskeleton#GO:0005200;structural molecule activity#GO:0005198 cellular localization#GO:0051641;localization#GO:0051179;retrograde axonal transport#GO:0008090;microtubule-based transport#GO:0099111;organelle localization#GO:0051640;axonal transport#GO:0098930;establishment of organelle localization#GO:0051656;microtubule-based movement#GO:0007018;mitochondrion localization#GO:0051646;microtubule-based process#GO:0007017;transport along microtubule#GO:0010970;establishment of localization#GO:0051234;transport#GO:0006810;intracellular transport#GO:0046907;organelle transport along microtubule#GO:0072384;cytoskeleton-dependent intracellular transport#GO:0030705;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;axo-dendritic transport#GO:0008088 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;organelle#GO:0043226;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;actin cytoskeleton#GO:0015629 actin and actin related protein#PC00039 HUMAN|HGNC=34243|UniProtKB=A8MYB1 A8MYB1 TMCO5B PTHR22422:SF1 TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 5B-RELATED TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 5B HUMAN|HGNC=24152|UniProtKB=Q96IZ7 Q96IZ7 RSRC1 PTHR31968:SF4 SERINE/ARGININE-RELATED PROTEIN 53 SERINE_ARGININE-RELATED PROTEIN 53 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170;alternative mRNA splicing, via spliceosome#GO:0000380 nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=26974|UniProtKB=Q8NEN9 Q8NEN9 PDZD8 PTHR21519:SF1 PDZ DOMAIN-CONTAINING PROTEIN 8 PDZ DOMAIN-CONTAINING PROTEIN 8 intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;inorganic ion homeostasis#GO:0098771;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;calcium ion homeostasis#GO:0055074;homeostatic process#GO:0042592;mitochondrial calcium ion homeostasis#GO:0051560;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion homeostasis#GO:0050801 mitochondria-associated endoplasmic reticulum membrane contact site#GO:0044233;cellular anatomical structure#GO:0110165;organelle#GO:0043226;organelle membrane contact site#GO:0044232 scaffold/adaptor protein#PC00226 HUMAN|HGNC=19312|UniProtKB=Q56P03 Q56P03 EAPP PTHR15967:SF1 E2F-ASSOCIATED PHOSPHOPROTEIN E2F-ASSOCIATED PHOSPHOPROTEIN transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of cell population proliferation#GO:0042127;regulation of transcription elongation by RNA polymerase II#GO:0034243;regulation of DNA-templated transcription elongation#GO:0032784;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;positive regulation of cell population proliferation#GO:0008284;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=7586|UniProtKB=Q02045 Q02045 MYL5 PTHR23049:SF8 MYOSIN REGULATORY LIGHT CHAIN 2 MYOSIN LIGHT CHAIN 5 ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;calcium ion binding#GO:0005509;protein binding#GO:0005515;metal ion binding#GO:0046872;cation binding#GO:0043169;myosin binding#GO:0017022;cytoskeletal protein binding#GO:0008092 myosin complex#GO:0016459;actin cytoskeleton#GO:0015629;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 actin or actin-binding cytoskeletal protein#PC00041;cytoskeletal protein#PC00085 HUMAN|HGNC=19628|UniProtKB=Q8NH09 Q8NH09 OR8S1 PTHR48001:SF103 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 8S1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=30140|UniProtKB=A7MCY6 A7MCY6 TBKBP1 PTHR14432:SF2 PROSAPIP2 PROTEIN/5-AZACYTIDINE INDUCED GENE 2 TANK-BINDING KINASE 1-BINDING PROTEIN 1 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=25841|UniProtKB=Q5VT97 Q5VT97 SYDE2 PTHR46150:SF1 RHO GTPASE-ACTIVATING PROTEIN 100F RHO GTPASE-ACTIVATING PROTEIN SYDE2 GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme activator activity#GO:0008047 regulation of Ras protein signal transduction#GO:0046578;regulation of small GTPase mediated signal transduction#GO:0051056;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;regulation of intracellular signal transduction#GO:1902531;regulation of cell communication#GO:0010646;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;cell migration#GO:0016477;cell motility#GO:0048870;cellular process#GO:0009987;regulation of biological process#GO:0050789 synaptic membrane#GO:0097060;cell junction#GO:0030054;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;synapse#GO:0045202;plasma membrane region#GO:0098590 protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HUMAN|HGNC=28183|UniProtKB=P0DTE5 P0DTE5 UGT2A2 PTHR48043:SF129 EG:EG0003.4 PROTEIN-RELATED UDP-GLUCURONOSYLTRANSFERASE 2A2 glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194;hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740;glucuronosyltransferase activity#GO:0015020 HUMAN|HGNC=7432|UniProtKB=P11586 P11586 MTHFD1 PTHR48099:SF1 C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC oxidoreductase activity#GO:0016491;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;catalytic activity#GO:0003824 modified amino acid metabolic process#GO:0006575;cellular process#GO:0009987;pteridine-containing compound metabolic process#GO:0042558;folic acid-containing compound metabolic process#GO:0006760;small molecule metabolic process#GO:0044281;biosynthetic process#GO:0009058;metabolic process#GO:0008152;tetrahydrofolate biosynthetic process#GO:0046654;tetrahydrofolate metabolic process#GO:0046653 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262 HUMAN|HGNC=24239|UniProtKB=O75069 O75069 TMCC2 PTHR17613:SF9 CEREBRAL PROTEIN-11-RELATED TRANSMEMBRANE AND COILED-COIL DOMAINS PROTEIN 2 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;metabolic process#GO:0008152;cellular process#GO:0009987 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 HUMAN|HGNC=13698|UniProtKB=Q9NYZ3 Q9NYZ3 GTSE1 PTHR21584:SF10 DIFFERENTIAL DISPLAY AND ACTIVATED BY P53 DDA3 /G2 S PHASE EXPRESSED 1 G2 AND S PHASE-EXPRESSED PROTEIN 1 cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;microtubule binding#GO:0008017;binding#GO:0005488;protein binding#GO:0005515 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;cytoplasmic microtubule#GO:0005881;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;organelle#GO:0043226;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165 p53 pathway#P00059>B99#G04697;p53 pathway#P00059>B99#P04613 HUMAN|HGNC=24650|UniProtKB=Q9H9B1 Q9H9B1 EHMT1 PTHR46307:SF2 G9A, ISOFORM B HISTONE-LYSINE N-METHYLTRANSFERASE EHMT1 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=20795|UniProtKB=Q8NCR9 Q8NCR9 CLRN3 PTHR31548:SF3 CLARIN CLARIN-3 HUMAN|HGNC=808|UniProtKB=Q9UN42 Q9UN42 ATP1B4 PTHR11523:SF12 SODIUM/POTASSIUM-DEPENDENT ATPASE BETA SUBUNIT PROTEIN ATP1B4 ATPase activator activity#GO:0001671;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;inorganic ion homeostasis#GO:0098771;import across plasma membrane#GO:0098739;export from cell#GO:0140352;intracellular monoatomic ion homeostasis#GO:0006873;sodium ion transport#GO:0006814;regulation of biological process#GO:0050789;import into cell#GO:0098657;chemical homeostasis#GO:0048878;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;regulation of DNA-templated transcription#GO:0006355;localization#GO:0051179;potassium ion homeostasis#GO:0055075;monoatomic cation transport#GO:0006812;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;inorganic ion import across plasma membrane#GO:0099587;metal ion transport#GO:0030001;homeostatic process#GO:0042592;regulation of biosynthetic process#GO:0009889;establishment of localization#GO:0051234;potassium ion import across plasma membrane#GO:1990573;regulation of gene expression#GO:0010468;inorganic cation import across plasma membrane#GO:0098659;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;transport#GO:0006810;potassium ion transport#GO:0006813;regulation of nucleobase-containing compound metabolic process#GO:0019219;monoatomic ion transmembrane transport#GO:0034220;regulation of RNA biosynthetic process#GO:2001141;potassium ion transmembrane transport#GO:0071805;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 ATPase dependent transmembrane transport complex#GO:0098533;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transmembrane transporter complex#GO:1902495;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane protein complex#GO:0098797;cation-transporting ATPase complex#GO:0090533;organelle envelope#GO:0031967;membrane protein complex#GO:0098796;organelle membrane#GO:0031090;nuclear inner membrane#GO:0005637;nuclear membrane#GO:0031965;transporter complex#GO:1990351;plasma membrane#GO:0005886;nuclear envelope#GO:0005635;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;nucleus#GO:0005634;cell periphery#GO:0071944;organelle inner membrane#GO:0019866;membrane#GO:0016020 transporter#PC00227;primary active transporter#PC00068 HUMAN|HGNC=714|UniProtKB=P15848 P15848 ARSB PTHR10342:SF276 ARYLSULFATASE ARYLSULFATASE B hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788 HUMAN|HGNC=55109|UniProtKB=A0A0X1KG70 A0A0X1KG70 OR4M2B PTHR48002:SF103 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 4M1-RELATED transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=5187|UniProtKB=Q99873 Q99873 PRMT1 PTHR11006:SF54 PROTEIN ARGININE N-METHYLTRANSFERASE PROTEIN ARGININE N-METHYLTRANSFERASE 1 histone methyltransferase activity#GO:0042054;N-methyltransferase activity#GO:0008170;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;histone modifying activity#GO:0140993;protein methyltransferase activity#GO:0008276;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a protein#GO:0140096 regulation of biological process#GO:0050789;cellular component organization#GO:0016043;chromatin remodeling#GO:0006338;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of gene expression#GO:0010468;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 protein modifying enzyme#PC00260 HUMAN|HGNC=15223|UniProtKB=Q8NGK3 Q8NGK3 OR52K2 PTHR26450:SF404 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 52K2 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=4718|UniProtKB=P10412 P10412 H1-4 PTHR11467:SF179 HISTONE H1 HISTONE H1.4 chromatin DNA binding#GO:0031490;chromatin binding#GO:0003682;nucleic acid binding#GO:0003676;binding#GO:0005488;protein-containing complex binding#GO:0044877;nucleosome binding#GO:0031491;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677 cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;organelle organization#GO:0006996;regulation of primary metabolic process#GO:0080090;negative regulation of DNA metabolic process#GO:0051053;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of cellular process#GO:0048523;chromosome organization#GO:0051276;cellular component organization or biogenesis#GO:0071840;regulation of DNA metabolic process#GO:0051052;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;negative regulation of DNA recombination#GO:0045910;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of DNA recombination#GO:0000018;chromosome condensation#GO:0030261;negative regulation of nucleobase-containing compound metabolic process#GO:0045934 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=24083|UniProtKB=Q6UXC1 Q6UXC1 MAMDC4 PTHR23282:SF129 APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR. APICAL ENDOSOMAL GLYCOPROTEIN HUMAN|HGNC=1224|UniProtKB=O15165 O15165 LDLRAD4 PTHR16514:SF4 LOW DENSITY LIPOPROTEIN RECEPTOR CLASS A DOMAIN-CONTAINING 4A LOW-DENSITY LIPOPROTEIN RECEPTOR CLASS A DOMAIN-CONTAINING PROTEIN 4 protein binding#GO:0005515;binding#GO:0005488 negative regulation of cell communication#GO:0010648;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of transforming growth factor beta receptor signaling pathway#GO:0017015;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;negative regulation of response to stimulus#GO:0048585;regulation of cellular response to growth factor stimulus#GO:0090287;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968 Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;early endosome membrane#GO:0031901;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;vesicle membrane#GO:0012506;membrane#GO:0016020;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;endosome membrane#GO:0010008;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;early endosome#GO:0005769;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=26417|UniProtKB=Q7RTX9 Q7RTX9 SLC16A14 PTHR11360:SF239 MONOCARBOXYLATE TRANSPORTER MONOCARBOXYLATE TRANSPORTER 14 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;carboxylic acid transmembrane transporter activity#GO:0046943;monocarboxylic acid transmembrane transporter activity#GO:0008028 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227 HUMAN|HGNC=28867|UniProtKB=Q9Y6M1 Q9Y6M1 IGF2BP2 PTHR10288:SF93 KH DOMAIN CONTAINING RNA BINDING PROTEIN INSULIN-LIKE GROWTH FACTOR 2 MRNA-BINDING PROTEIN 2 mRNA 3'-UTR binding#GO:0003730;RNA binding#GO:0003723;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488 post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;negative regulation of RNA catabolic process#GO:1902369;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;positive regulation of gene expression#GO:0010628;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA stability#GO:0043487;anatomical structure development#GO:0048856;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;negative regulation of catabolic process#GO:0009895;system development#GO:0048731;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of RNA metabolic process#GO:0051253;regulation of mRNA metabolic process#GO:1903311;multicellular organism development#GO:0007275;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604;nervous system development#GO:0007399;mRNA stabilization#GO:0048255;animal gross anatomical part developmental process#GO:0160108;RNA stabilization#GO:0043489;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of biological quality#GO:0065008;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;regulation of biological process#GO:0050789;regulation of mRNA stability#GO:0043488;negative regulation of metabolic process#GO:0009892 nucleus#GO:0005634;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;organelle#GO:0043226;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytoplasmic stress granule#GO:0010494;membraneless organelle#GO:0043228 RNA metabolism protein#PC00031 HUMAN|HGNC=8352|UniProtKB=Q8NGP8 Q8NGP8 OR5M1 PTHR48018:SF100 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5M1 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cellular process#GO:0009987;signal transduction#GO:0007165;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signaling#GO:0023052;regulation of cellular process#GO:0050794;sensory perception of smell#GO:0007608;response to stimulus#GO:0050896;nervous system process#GO:0050877;sensory perception#GO:0007600;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=14615|UniProtKB=Q9BXP8 Q9BXP8 PAPPA2 PTHR46130:SF1 LAMGL DOMAIN-CONTAINING PROTEIN PAPPALYSIN-2 metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 metabolic process#GO:0008152;proteolysis#GO:0006508;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=7449|UniProtKB=Q13613 Q13613 MTMR1 PTHR10807:SF40 MYOTUBULARIN-RELATED PHOSPHATIDYLINOSITOL-3-PHOSPHATE PHOSPHATASE MTMR1 hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;phosphatidylinositol-3,5-bisphosphate phosphatase activity#GO:0106018;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788 primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;phosphate-containing compound metabolic process#GO:0006796;phospholipid dephosphorylation#GO:0046839;glycerophospholipid metabolic process#GO:0006650;glycerolipid metabolic process#GO:0046486;phospholipid metabolic process#GO:0006644;phosphatidylinositol dephosphorylation#GO:0046856;metabolic process#GO:0008152;phosphatidylinositol metabolic process#GO:0046488;lipid metabolic process#GO:0006629;dephosphorylation#GO:0016311;lipid modification#GO:0030258 membrane#GO:0016020;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 phosphatase#PC00181 HUMAN|HGNC=19736|UniProtKB=A6NMN3 A6NMN3 FAM170B PTHR33517:SF2 PROTEIN FAM170B-RELATED PROTEIN FAM170B reproductive process#GO:0022414;fertilization#GO:0009566;sexual reproduction#GO:0019953 membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;acrosomal vesicle#GO:0001669;intracellular organelle#GO:0043229;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular vesicle#GO:0097708;secretory vesicle#GO:0099503;vesicle#GO:0031982 HUMAN|HGNC=26351|UniProtKB=Q8IXT1 Q8IXT1 DDIAS PTHR35537:SF1 DNA DAMAGE-INDUCIBLE APOPTOSIS SUPPRESSOR PROTEIN DDIAS DNA DAMAGE-INDUCED APOPTOSIS SUPPRESSOR PROTEIN nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=30244|UniProtKB=Q6P1A2 Q6P1A2 LPCAT3 PTHR13906:SF14 PORCUPINE LYSOPHOSPHOLIPID ACYLTRANSFERASE 5 acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746 lipid modification#GO:0030258;glycerophospholipid biosynthetic process#GO:0046474;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;biosynthetic process#GO:0009058;phosphatidylcholine biosynthetic process#GO:0006656;phosphatidylcholine metabolic process#GO:0046470;glycerophospholipid metabolic process#GO:0006650;lipid biosynthetic process#GO:0008610;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;organophosphate metabolic process#GO:0019637;organophosphate biosynthetic process#GO:0090407;phospholipid metabolic process#GO:0006644;glycerolipid metabolic process#GO:0046486;phospholipid biosynthetic process#GO:0008654;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793 cellular anatomical structure#GO:0110165;membrane#GO:0016020 acetyltransferase#PC00038 HUMAN|HGNC=7180|UniProtKB=Q10571 Q10571 MN1 PTHR15821:SF0 PROTEIN MN1 TRANSCRIPTIONAL ACTIVATOR MN1 HUMAN|HGNC=1329|UniProtKB=Q6PML9 Q6PML9 SLC30A9 PTHR13414:SF9 HUEL-CATION TRANSPORTER PROTON-COUPLED ZINC ANTIPORTER SLC30A9, MITOCHONDRIAL monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;inorganic ion homeostasis#GO:0098771;transition metal ion transport#GO:0000041;homeostatic process#GO:0042592;metal ion transport#GO:0030001;intracellular monoatomic ion homeostasis#GO:0006873;establishment of localization#GO:0051234;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;chemical homeostasis#GO:0048878;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;transport#GO:0006810;zinc ion transport#GO:0006829;monoatomic ion homeostasis#GO:0050801 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 transporter#PC00227 HUMAN|HGNC=28226|UniProtKB=Q9BRT9 Q9BRT9 GINS4 PTHR21206:SF0 SLD5 PROTEIN DNA REPLICATION COMPLEX GINS PROTEIN SLD5 response to stress#GO:0006950;double-strand break repair via break-induced replication#GO:0000727;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA damage response#GO:0006974;DNA recombination#GO:0006310;macromolecule metabolic process#GO:0043170;double-strand break repair#GO:0006302;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;double-strand break repair via homologous recombination#GO:0000724;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;recombinational repair#GO:0000725;cellular response to stress#GO:0033554 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;chromosome#GO:0005694;organelle lumen#GO:0043233;DNA replication preinitiation complex#GO:0031261;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;protein-DNA complex#GO:0032993;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;GINS complex#GO:0000811;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232 HUMAN|HGNC=4332|UniProtKB=Q9NZM4 Q9NZM4 BICRA PTHR15572:SF1 GLIOMA TUMOR SUPPRESSOR CANDIDATE REGION GENE 1 BRD4-INTERACTING CHROMATIN-REMODELING COMPLEX-ASSOCIATED PROTEIN regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254 membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;chromatin#GO:0000785;nucleus#GO:0005634;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;ATPase complex#GO:1904949;SWI/SNF complex#GO:0016514;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;SWI/SNF superfamily-type complex#GO:0070603;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=4923|UniProtKB=P52789 P52789 HK2 PTHR19443:SF4 HEXOKINASE HEXOKINASE-2 transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;carbohydrate kinase activity#GO:0019200;catalytic activity#GO:0003824;transferase activity#GO:0016740;hexokinase activity#GO:0004396;phosphotransferase activity, alcohol group as acceptor#GO:0016773 glucose 6-phosphate metabolic process#GO:0051156;catabolic process#GO:0009056;carbohydrate metabolic process#GO:0005975;homeostatic process#GO:0042592;nucleoside phosphate metabolic process#GO:0006753;purine ribonucleotide catabolic process#GO:0009154;nucleoside diphosphate catabolic process#GO:0009134;ribonucleoside diphosphate catabolic process#GO:0009191;organophosphate catabolic process#GO:0046434;cellular respiration#GO:0045333;purine nucleotide catabolic process#GO:0006195;nucleobase-containing compound metabolic process#GO:0006139;nucleobase-containing compound catabolic process#GO:0034655;carbohydrate derivative metabolic process#GO:1901135;ribonucleotide catabolic process#GO:0009261;energy derivation by oxidation of organic compounds#GO:0015980;intracellular chemical homeostasis#GO:0055082;nucleotide catabolic process#GO:0009166;small molecule metabolic process#GO:0044281;pyridine nucleotide catabolic process#GO:0019364;phosphorus metabolic process#GO:0006793;carboxylic acid metabolic process#GO:0019752;ribonucleoside diphosphate metabolic process#GO:0009185;carbohydrate homeostasis#GO:0033500;intracellular glucose homeostasis#GO:0001678;oxoacid metabolic process#GO:0043436;nicotinamide nucleotide metabolic process#GO:0046496;ATP metabolic process#GO:0046034;purine-containing compound catabolic process#GO:0072523;glucose metabolic process#GO:0006006;metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;monosaccharide metabolic process#GO:0005996;chemical homeostasis#GO:0048878;nucleoside phosphate catabolic process#GO:1901292;carbohydrate derivative catabolic process#GO:1901136;nucleoside triphosphate metabolic process#GO:0009141;hexose metabolic process#GO:0019318;primary metabolic process#GO:0044238;purine nucleoside triphosphate metabolic process#GO:0009144;aerobic respiration#GO:0009060;purine ribonucleoside diphosphate catabolic process#GO:0009181;nucleoside diphosphate metabolic process#GO:0009132;pyridine-containing compound metabolic process#GO:0072524;organophosphate metabolic process#GO:0019637;purine ribonucleoside triphosphate metabolic process#GO:0009205;glycolytic process#GO:0006096;ADP metabolic process#GO:0046031;cellular homeostasis#GO:0019725;generation of precursor metabolites and energy#GO:0006091;purine ribonucleoside diphosphate metabolic process#GO:0009179;pyruvate metabolic process#GO:0006090;monocarboxylic acid metabolic process#GO:0032787;purine nucleotide metabolic process#GO:0006163;pyridine-containing compound catabolic process#GO:0072526;purine-containing compound metabolic process#GO:0072521;carbohydrate catabolic process#GO:0016052;nucleotide metabolic process#GO:0009117;purine nucleoside diphosphate metabolic process#GO:0009135;ribonucleotide metabolic process#GO:0009259;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;glucose homeostasis#GO:0042593;nucleobase-containing small molecule metabolic process#GO:0055086;purine nucleoside diphosphate catabolic process#GO:0009137;ADP catabolic process#GO:0046032 cytoplasm#GO:0005737;organelle outer membrane#GO:0031968;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;membrane#GO:0016020;cytosol#GO:0005829;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;mitochondrial outer membrane#GO:0005741;cytoplasmic side of membrane#GO:0098562;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;organelle envelope#GO:0031967;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;side of membrane#GO:0098552;outer membrane#GO:0019867;intracellular organelle#GO:0043229 metabolite interconversion enzyme#PC00262;kinase#PC00137;transferase#PC00220 Pentose phosphate pathway#P02762>Hexokinase#P03079;Fructose galactose metabolism#P02744>Hexokinase#P02966;Glycolysis#P00024>Hexokinase#P00677 HUMAN|HGNC=20757|UniProtKB=Q9H8W4 Q9H8W4 PLEKHF2 PTHR46280:SF1 PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY F MEMBER 2-RELATED PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY F MEMBER 2 ion binding#GO:0043167;phosphatidylinositol binding#GO:0035091;small molecule binding#GO:0036094;anion binding#GO:0043168;binding#GO:0005488 cellular component organization#GO:0016043;localization#GO:0051179;cellular localization#GO:0051641;lysosomal transport#GO:0007041;endosome to lysosome transport#GO:0008333;endomembrane system organization#GO:0010256;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle organization#GO:0006996;vesicle organization#GO:0016050;endosome organization#GO:0007032;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;vacuolar transport#GO:0007034;transport#GO:0006810;intracellular transport#GO:0046907 intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular vesicle#GO:0097708;vesicle#GO:0031982 HUMAN|HGNC=17007|UniProtKB=O95147 O95147 DUSP14 PTHR45961:SF5 IP21249P DUAL SPECIFICITY PROTEIN PHOSPHATASE 14 catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721;protein serine/threonine phosphatase activity#GO:0004722 Oxidative stress response#P00046>MKP5#P01131 HUMAN|HGNC=54084|UniProtKB=P0CG12 P0CG12 DERPC PTHR28605:SF2 CTF8, CHROMOSOME TRANSMISSION FIDELITY FACTOR 8 HOMOLOG (S. CEREVISIAE) DECREASED EXPRESSION IN RENAL AND PROSTATE CANCER PROTEIN biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biosynthetic process#GO:0009889;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of DNA metabolic process#GO:0051052;positive regulation of DNA metabolic process#GO:0051054;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=29884|UniProtKB=Q8TF42 Q8TF42 UBASH3B PTHR16469:SF29 UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING PROTEIN B phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 signal transduction#GO:0007165;coagulation#GO:0050817;regulation of monoatomic ion transmembrane transport#GO:0034765;cellular process#GO:0009987;cell-cell adhesion#GO:0098609;response to stress#GO:0006950;regulation of multicellular organismal process#GO:0051239;negative regulation of signal transduction#GO:0009968;platelet aggregation#GO:0070527;cell surface receptor signaling pathway#GO:0007166;regulation of localization#GO:0032879;regulation of transport#GO:0051049;regulation of release of sequestered calcium ion into cytosol#GO:0051279;regulation of biological process#GO:0050789;regulation of multicellular organismal development#GO:2000026;negative regulation of biological process#GO:0048519;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of body fluid levels#GO:0050878;cell adhesion#GO:0007155;regulation of bone resorption#GO:0045124;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;regulation of myeloid cell differentiation#GO:0045637;regulation of biological quality#GO:0065008;wound healing#GO:0042060;negative regulation of cell communication#GO:0010648;regulation of cell development#GO:0060284;regulation of bone remodeling#GO:0046850;response to wounding#GO:0009611;regulation of calcium ion transport#GO:0051924;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;homotypic cell-cell adhesion#GO:0034109;regulation of monoatomic ion transport#GO:0043269;negative regulation of response to stimulus#GO:0048585;multicellular organismal process#GO:0032501;regulation of response to stimulus#GO:0048583;regulation of cell differentiation#GO:0045595;regulation of monoatomic cation transmembrane transport#GO:1904062;negative regulation of cellular process#GO:0048523;blood coagulation#GO:0007596;platelet activation#GO:0030168;cellular response to stimulus#GO:0051716;negative regulation of multicellular organismal process#GO:0051241;regulation of transmembrane transport#GO:0034762;hemostasis#GO:0007599;regulation of developmental process#GO:0050793;regulation of cell communication#GO:0010646;regulation of metal ion transport#GO:0010959;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cell activation#GO:0001775;regulation of tissue remodeling#GO:0034103;regulation of hemopoiesis#GO:1903706;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=24935|UniProtKB=Q8TD90 Q8TD90 MAGEE2 PTHR11736:SF7 MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN MELANOMA-ASSOCIATED ANTIGEN E2 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 scaffold/adaptor protein#PC00226 HUMAN|HGNC=17166|UniProtKB=Q86VR8 Q86VR8 FJX1 PTHR13147:SF5 FOUR-JOINTED BOX PROTEIN 1 FOUR-JOINTED BOX PROTEIN 1 protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824 regulation of biological process#GO:0050789;cellular process#GO:0009987;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;signaling#GO:0023052;cell communication#GO:0007154 HUMAN|HGNC=25965|UniProtKB=Q8IUZ0 Q8IUZ0 LRRC49 PTHR45973:SF8 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED LEUCINE-RICH REPEAT-CONTAINING PROTEIN 49 protein-binding activity modulator#PC00095;phosphatase modulator#PC00184 HUMAN|HGNC=29994|UniProtKB=Q6ZWK6 Q6ZWK6 TMPRSS11F PTHR24253:SF65 TRANSMEMBRANE PROTEASE SERINE TRANSMEMBRANE PROTEASE SERINE 11F peptidase activity#GO:0008233;serine hydrolase activity#GO:0017171;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;serine-type peptidase activity#GO:0008236;catalytic activity#GO:0003824 metabolic process#GO:0008152;proteolysis#GO:0006508;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;protein processing#GO:0016485;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 protein modifying enzyme#PC00260;protease#PC00190;serine protease#PC00203 HUMAN|HGNC=3560|UniProtKB=Q01469 Q01469 FABP5 PTHR11955:SF58 FATTY ACID BINDING PROTEIN FATTY ACID-BINDING PROTEIN 5 anion binding#GO:0043168;carboxylic acid binding#GO:0031406;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;organic acid binding#GO:0043177;fatty acid binding#GO:0005504;lipid binding#GO:0008289 lipid transport#GO:0006869;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;localization#GO:0051179;fatty acid transport#GO:0015908;monocarboxylic acid transport#GO:0015718;lipid localization#GO:0010876;organic acid transport#GO:0015849;carboxylic acid transport#GO:0046942;transport#GO:0006810 cytosol#GO:0005829;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 transfer/carrier protein#PC00219 HUMAN|HGNC=9755|UniProtKB=Q15274 Q15274 QPRT PTHR32179:SF3 NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING] NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING] glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;transferase activity#GO:0016740;pentosyltransferase activity#GO:0016763 NAD+ metabolic process#GO:0019674;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;nicotinamide nucleotide metabolic process#GO:0046496;carboxylic acid catabolic process#GO:0046395;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing small molecule metabolic process#GO:0055086;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521;pyridine-containing compound catabolic process#GO:0072526;purine nucleotide metabolic process#GO:0006163;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;nucleoside phosphate metabolic process#GO:0006753;small molecule catabolic process#GO:0044282;purine nucleotide biosynthetic process#GO:0006164;oxoacid metabolic process#GO:0043436;purine-containing compound biosynthetic process#GO:0072522;pyridine-containing compound metabolic process#GO:0072524;organophosphate biosynthetic process#GO:0090407;nucleotide metabolic process#GO:0009117;nucleotide biosynthetic process#GO:0009165 HUMAN|HGNC=26957|UniProtKB=Q9NPB8 Q9NPB8 GPCPD1 PTHR22958:SF43 GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE GLYCEROPHOSPHOCHOLINE PHOSPHODIESTERASE GPCPD1 catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphoric diester hydrolase activity#GO:0008081;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578 primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;lipid catabolic process#GO:0016042;glycerophospholipid metabolic process#GO:0006650;glycerolipid metabolic process#GO:0046486;catabolic process#GO:0009056;phospholipid catabolic process#GO:0009395;phospholipid metabolic process#GO:0006644;glycerolipid catabolic process#GO:0046503;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;organophosphate catabolic process#GO:0046434;glycerophospholipid catabolic process#GO:0046475 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 phosphodiesterase#PC00185;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=10627|UniProtKB=P10147 P10147 CCL3 PTHR12015:SF183 SMALL INDUCIBLE CYTOKINE A C-C MOTIF CHEMOKINE 26-RELATED locomotion#GO:0040011;response to stimulus#GO:0050896;granulocyte chemotaxis#GO:0071621;cell motility#GO:0048870;cellular response to stimulus#GO:0051716;cell chemotaxis#GO:0060326;chemotaxis#GO:0006935;immune system process#GO:0002376;cellular response to chemical stimulus#GO:0070887;taxis#GO:0042330;response to chemical#GO:0042221;granulocyte migration#GO:0097530;cell migration#GO:0016477;cellular process#GO:0009987;response to external stimulus#GO:0009605;myeloid leukocyte migration#GO:0097529;leukocyte chemotaxis#GO:0030595;leukocyte migration#GO:0050900 cytokine#PC00083 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CHK#P00856 HUMAN|HGNC=21041|UniProtKB=Q9UBI9 Q9UBI9 HECA PTHR13425:SF3 HEADCASE PROTEIN HEADCASE PROTEIN HOMOLOG HUMAN|HGNC=16449|UniProtKB=A6NLU0 A6NLU0 RFPL4A PTHR24103:SF666 E3 UBIQUITIN-PROTEIN LIGASE TRIM RET FINGER PROTEIN-LIKE 4A-RELATED aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746 immune system process#GO:0002376;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;regulation of biosynthetic process#GO:0009889;innate immune response#GO:0045087;defense response#GO:0006952;regulation of gene expression#GO:0010468;response to external stimulus#GO:0009605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;defense response to symbiont#GO:0140546;immune response#GO:0006955;defense response to other organism#GO:0098542;response to other organism#GO:0051707;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=242|UniProtKB=P41586 P41586 ADCYAP1R1 PTHR45620:SF12 PDF RECEPTOR-LIKE PROTEIN-RELATED PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE TYPE I RECEPTOR G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 Gonadotropin-releasing hormone receptor pathway#P06664>PAC1R#G06898;Gonadotropin-releasing hormone receptor pathway#P06664>PAC1-R#P06712;Gonadotropin-releasing hormone receptor pathway#P06664>PAC1R#G06685 HUMAN|HGNC=4953|UniProtKB=Q30154 Q30154 HLA-DRB5 PTHR19944:SF97 MHC CLASS II-RELATED HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR BETA 4 CHAIN-RELATED binding#GO:0005488;peptide binding#GO:0042277;antigen binding#GO:0003823;protein-containing complex binding#GO:0044877 regulation of lymphocyte activation#GO:0051249;regulation of cell activation#GO:0050865;positive regulation of multicellular organismal process#GO:0051240;regulation of biological process#GO:0050789;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;regulation of leukocyte activation#GO:0002694;immune system process#GO:0002376;regulation of multicellular organismal process#GO:0051239;regulation of T cell activation#GO:0050863;positive regulation of T cell activation#GO:0050870;cellular component assembly#GO:0022607;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of immune system process#GO:0002684;cellular component biogenesis#GO:0044085;positive regulation of cell-cell adhesion#GO:0022409;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;positive regulation of leukocyte activation#GO:0002696;regulation of cellular process#GO:0050794;regulation of cell-cell adhesion#GO:0022407;regulation of immune system process#GO:0002682;positive regulation of cell adhesion#GO:0045785;antigen processing and presentation#GO:0019882;positive regulation of lymphocyte activation#GO:0051251;regulation of immune response#GO:0050776;positive regulation of cell activation#GO:0050867;positive regulation of leukocyte cell-cell adhesion#GO:1903039;biological regulation#GO:0065007;regulation of cell adhesion#GO:0030155;positive regulation of response to stimulus#GO:0048584;positive regulation of cellular process#GO:0048522;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;regulation of leukocyte cell-cell adhesion#GO:1903037 endosome#GO:0005768;endosome membrane#GO:0010008;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;lysosome#GO:0005764;plasma membrane protein complex#GO:0098797;vesicle#GO:0031982;lytic vacuole membrane#GO:0098852;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;late endosome membrane#GO:0031902;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;vacuolar membrane#GO:0005774;lytic vacuole#GO:0000323;lysosomal membrane#GO:0005765;cell periphery#GO:0071944;membrane#GO:0016020;vesicle membrane#GO:0012506;cytoplasm#GO:0005737;plasma membrane#GO:0005886;vacuole#GO:0005773;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;late endosome#GO:0005770;cytoplasmic vesicle membrane#GO:0030659 major histocompatibility complex protein#PC00149 HUMAN|HGNC=8232|UniProtKB=Q96R48 Q96R48 OR2A5 PTHR26453:SF232 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2A5 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 system process#GO:0003008;nervous system process#GO:0050877;sensory perception#GO:0007600;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;response to chemical#GO:0042221;response to stimulus#GO:0050896;detection of chemical stimulus#GO:0009593;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=54200|UniProtKB=A0A1B0GVR7 A0A1B0GVR7 FAM240C PTHR40387:SF4 PROTEIN FAM240B PROTEIN FAM240C HUMAN|HGNC=55184|UniProtKB=A0A3B3IT52 A0A3B3IT52 MSANTD5 PTHR31512:SF2 GENE 12569-RELATED MYB_SANT DNA BINDING DOMAIN CONTAINING 5 HUMAN|HGNC=33104|UniProtKB=Q3SY52 Q3SY52 ZIK1 PTHR24377:SF688 IP01015P-RELATED ZINC FINGER PROTEIN INTERACTING WITH RIBONUCLEOPROTEIN K sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=10953|UniProtKB=Q96BD0 Q96BD0 SLCO4A1 PTHR11388:SF164 ORGANIC ANION TRANSPORTER SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 4A1 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;active transmembrane transporter activity#GO:0022804 cellular process#GO:0009987;transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;cell periphery#GO:0071944;basal plasma membrane#GO:0009925;membrane#GO:0016020;basolateral plasma membrane#GO:0016323;basal part of cell#GO:0045178 transporter#PC00227 HUMAN|HGNC=11269|UniProtKB=O43609 O43609 SPRY1 PTHR12365:SF10 SPROUTY PROTEIN SPROUTY HOMOLOG 1 molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;protein kinase inhibitor activity#GO:0004860;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;protein kinase regulator activity#GO:0019887;kinase inhibitor activity#GO:0019210;enzyme inhibitor activity#GO:0004857 regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;regulation of Ras protein signal transduction#GO:0046578;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of MAPK cascade#GO:0043409;regulation of biological process#GO:0050789;regulation of ERBB signaling pathway#GO:1901184;negative regulation of biological process#GO:0048519;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of response to stimulus#GO:0048583;regulation of MAPK cascade#GO:0043408;negative regulation of cellular process#GO:0048523;regulation of small GTPase mediated signal transduction#GO:0051056;negative regulation of signal transduction#GO:0009968;regulation of epidermal growth factor receptor signaling pathway#GO:0042058;biological regulation#GO:0065007;regulation of fibroblast growth factor receptor signaling pathway#GO:0040036;regulation of cellular response to growth factor stimulus#GO:0090287;regulation of signal transduction#GO:0009966;negative regulation of response to stimulus#GO:0048585;regulation of ERK1 and ERK2 cascade#GO:0070372;negative regulation of ERK1 and ERK2 cascade#GO:0070373 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 scaffold/adaptor protein#PC00226 EGF receptor signaling pathway#P00018>Spry#P00541;FGF signaling pathway#P00021>Spry#P00626;EGF receptor signaling pathway#P00018>SPRY#G01511 HUMAN|HGNC=7127|UniProtKB=P40692 P40692 MLH1 PTHR10073:SF57 DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL DNA MISMATCH REPAIR PROTEIN MLH1 catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;DNA nuclease activity#GO:0004536;catalytic activity, acting on DNA#GO:0140097;DNA endonuclease activity#GO:0004520;nuclease activity#GO:0004518;endonuclease activity#GO:0004519 multicellular organism development#GO:0007275;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;developmental process#GO:0032502;DNA damage response#GO:0006974;gene expression#GO:0010467;multicellular organismal process#GO:0032501;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;response to stress#GO:0006950;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;anatomical structure development#GO:0048856;immune system development#GO:0002520;system development#GO:0048731;immune system process#GO:0002376;animal gross anatomical part developmental process#GO:0160108;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;production of molecular mediator of immune response#GO:0002440;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;somatic diversification of immune receptors#GO:0002200;mismatch repair#GO:0006298;cellular response to stimulus#GO:0051716 nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 DNA metabolism protein#PC00009 HUMAN|HGNC=22916|UniProtKB=Q9C0B9 Q9C0B9 ZCCHC2 PTHR46939:SF1 ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 2 ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 2 HUMAN|HGNC=8065|UniProtKB=Q9UKX7 Q9UKX7 NUP50 PTHR23138:SF141 RAN BINDING PROTEIN NUCLEAR PORE COMPLEX PROTEIN NUP50 nuclear transport#GO:0051169;protein import into nucleus#GO:0006606;protein transport#GO:0015031;localization#GO:0051179;cellular localization#GO:0051641;nucleocytoplasmic transport#GO:0006913;protein localization to organelle#GO:0033365;intracellular protein localization#GO:0008104;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;import into nucleus#GO:0051170;macromolecule localization#GO:0033036;protein localization to nucleus#GO:0034504 intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;nucleus#GO:0005634;organelle envelope#GO:0031967;nuclear pore#GO:0005643;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229 scaffold/adaptor protein#PC00226 HUMAN|HGNC=23707|UniProtKB=Q9P255 Q9P255 ZNF492 PTHR24384:SF108 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED ZINC FINGER PROTEIN 492-RELATED sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA-binding transcription factor#PC00218 HUMAN|HGNC=24143|UniProtKB=Q969K7 Q969K7 TMEM54 PTHR31258:SF2 KERATINOCYTE-ASSOCIATED PROTEIN 3 TRANSMEMBRANE PROTEIN 54 HUMAN|HGNC=16299|UniProtKB=O15204 O15204 ADAMDEC1 PTHR11905:SF125 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN ADAM DEC1 catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;primary metabolic process#GO:0044238;proteolysis#GO:0006508;metabolic process#GO:0008152 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 protease#PC00190;metalloprotease#PC00153 HUMAN|HGNC=12119|UniProtKB=A0A0B4J277 A0A0B4J277 TRAV22 PTHR19339:SF2 T CELL RECEPTOR ALPHA VARIABLE 39 T CELL RECEPTOR ALPHA VARIABLE 22 HUMAN|HGNC=1777|UniProtKB=Q00534 Q00534 CDK6 PTHR24056:SF130 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE 6 catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=11173|UniProtKB=O60749 O60749 SNX2 PTHR10555:SF31 SORTING NEXIN SORTING NEXIN-2 phosphatidylinositol binding#GO:0035091;small molecule binding#GO:0036094;binding#GO:0005488;anion binding#GO:0043168;ion binding#GO:0043167 intracellular transport#GO:0046907;transport#GO:0006810;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;endosomal transport#GO:0016197;retrograde transport, endosome to Golgi#GO:0042147;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;cytosolic transport#GO:0016482 endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;membrane#GO:0016020;vesicle membrane#GO:0012506;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;vesicle#GO:0031982;retromer complex#GO:0030904;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endosome membrane#GO:0010008;endosome#GO:0005768;intracellular organelle#GO:0043229 scaffold/adaptor protein#PC00226 HUMAN|HGNC=34409|UniProtKB=A6NHN6 A6NHN6 NPIPB15 PTHR15438:SF4 NUCLEAR PORE COMPLEX INTERACTING PROTEIN NUCLEAR PORE COMPLEX-INTERACTING PROTEIN FAMILY MEMBER B15-RELATED HUMAN|HGNC=28519|UniProtKB=Q8NCR3 Q8NCR3 MFI PTHR33504:SF2 NADH DEHYDROGENASE (UBIQUINONE) 1 BETA SUBCOMPLEX, 4 PROTEIN MFI metabolite interconversion enzyme#PC00262;dehydrogenase#PC00092;oxidoreductase#PC00176 HUMAN|HGNC=33203|UniProtKB=A8MWA4 A8MWA4 ZNF705EP PTHR24381:SF312 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 705EP-RELATED sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690 regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=17845|UniProtKB=O43704 O43704 SULT1B1 PTHR11783:SF14 SULFOTRANSFERASE SULT SULFOTRANSFERASE 1B1 transferase activity, transferring sulphur-containing groups#GO:0016782;sulfotransferase activity#GO:0008146;transferase activity#GO:0016740;catalytic activity#GO:0003824 sulfur compound metabolic process#GO:0006790;metabolic process#GO:0008152;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 metabolite interconversion enzyme#PC00262;transferase#PC00220 HUMAN|HGNC=11424|UniProtKB=O43815 O43815 STRN PTHR15653:SF2 STRIATIN STRIATIN protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 response to stimulus#GO:0050896;Wnt signaling pathway#GO:0016055;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583 cell junction#GO:0030054;dendritic tree#GO:0097447;dendrite#GO:0030425;plasma membrane bounded cell projection#GO:0120025;somatodendritic compartment#GO:0036477;neuronal cell body#GO:0043025;cell projection#GO:0042995;protein-containing complex#GO:0032991;synapse#GO:0045202;cellular anatomical structure#GO:0110165;neuron projection#GO:0043005;cell body#GO:0044297;postsynapse#GO:0098794 HUMAN|HGNC=20134|UniProtKB=Q86SX6 Q86SX6 GLRX5 PTHR10293:SF16 GLUTAREDOXIN FAMILY MEMBER GLUTAREDOXIN-RELATED PROTEIN 5, MITOCHONDRIAL catalytic activity#GO:0003824;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;disulfide oxidoreductase activity#GO:0015036;oxidoreductase activity#GO:0016491 iron-sulfur cluster assembly#GO:0016226;cellular component assembly#GO:0022607;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229 reductase#PC00198;oxidoreductase#PC00176 HUMAN|HGNC=29643|UniProtKB=Q9BV36 Q9BV36 MLPH PTHR14555:SF1 MYELIN-ASSOCIATED OLIGODENDROCYTIC BASIC PROTEIN MOBP -RELATED MELANOPHILIN protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;myosin binding#GO:0017022;binding#GO:0005488 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cortical actin cytoskeleton#GO:0030864;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cortical cytoskeleton#GO:0030863;actin cytoskeleton#GO:0015629;cell periphery#GO:0071944;cell cortex#GO:0005938 myelin protein#PC00161 HUMAN|HGNC=30946|UniProtKB=A6NK53 A6NK53 ZNF233 PTHR24377:SF705 IP01015P-RELATED ZINC FINGER PROTEIN 233 cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=4952|UniProtKB=P13762 P13762 HLA-DRB4 PTHR19944:SF97 MHC CLASS II-RELATED HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR BETA 4 CHAIN-RELATED protein-containing complex binding#GO:0044877;binding#GO:0005488;antigen binding#GO:0003823;peptide binding#GO:0042277 regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;regulation of leukocyte cell-cell adhesion#GO:1903037;positive regulation of cell activation#GO:0050867;biological regulation#GO:0065007;positive regulation of leukocyte cell-cell adhesion#GO:1903039;regulation of cell adhesion#GO:0030155;positive regulation of response to stimulus#GO:0048584;positive regulation of cellular process#GO:0048522;antigen processing and presentation#GO:0019882;positive regulation of lymphocyte activation#GO:0051251;regulation of immune response#GO:0050776;regulation of immune system process#GO:0002682;regulation of cell-cell adhesion#GO:0022407;regulation of cellular process#GO:0050794;positive regulation of cell adhesion#GO:0045785;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;positive regulation of leukocyte activation#GO:0002696;regulation of multicellular organismal process#GO:0051239;regulation of T cell activation#GO:0050863;cellular component assembly#GO:0022607;positive regulation of T cell activation#GO:0050870;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of immune system process#GO:0002684;cellular component biogenesis#GO:0044085;positive regulation of cell-cell adhesion#GO:0022409;immune system process#GO:0002376;regulation of lymphocyte activation#GO:0051249;positive regulation of multicellular organismal process#GO:0051240;regulation of cell activation#GO:0050865;regulation of biological process#GO:0050789;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;regulation of leukocyte activation#GO:0002694 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome membrane#GO:0010008;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;lysosome#GO:0005764;plasma membrane protein complex#GO:0098797;lytic vacuole membrane#GO:0098852;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;lytic vacuole#GO:0000323;vacuolar membrane#GO:0005774;late endosome membrane#GO:0031902;plasma membrane#GO:0005886;vacuole#GO:0005773;cytoplasm#GO:0005737;late endosome#GO:0005770;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;lysosomal membrane#GO:0005765;cell periphery#GO:0071944;vesicle membrane#GO:0012506;membrane#GO:0016020 major histocompatibility complex protein#PC00149 HUMAN|HGNC=29811|UniProtKB=Q496H8 Q496H8 NRN1L PTHR15902:SF2 NEURITIN-RELATED NEURITIN-LIKE PROTEIN anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;cell development#GO:0048468;developmental cell growth#GO:0048588;cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;cell differentiation#GO:0030154;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;neuron development#GO:0048666;developmental growth involved in morphogenesis#GO:0060560;neuron projection extension#GO:1990138;system development#GO:0048731;anatomical structure development#GO:0048856;cellular process#GO:0009987;neuron projection development#GO:0031175;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection morphogenesis#GO:0120039;growth#GO:0040007;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;neuron differentiation#GO:0030182;neurogenesis#GO:0022008;cell projection morphogenesis#GO:0048858;developmental growth#GO:0048589;cell growth#GO:0016049;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=18610|UniProtKB=Q6VAB6 Q6VAB6 KSR2 PTHR23257:SF775 SERINE-THREONINE PROTEIN KINASE KINASE SUPPRESSOR OF RAS 2 protein kinase activity#GO:0004672;catalytic activity, acting on a protein#GO:0140096;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;calcium-mediated signaling#GO:0019722;Ras protein signal transduction#GO:0007265;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;intracellular signaling cassette#GO:0141124;signaling#GO:0023052;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789 plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;cytosol#GO:0005829;membrane#GO:0016020 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=26437|UniProtKB=Q96NA8 Q96NA8 TSNARE1 PTHR19957:SF38 SYNTAXIN T-SNARE DOMAIN-CONTAINING PROTEIN 1 SNAP receptor activity#GO:0005484;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 vesicle fusion#GO:0006906;cellular component organization#GO:0016043;cellular localization#GO:0051641;localization#GO:0051179;protein transport#GO:0015031;vesicle-mediated transport#GO:0016192;organelle fusion#GO:0048284;organelle membrane fusion#GO:0090174;membrane organization#GO:0061024;membrane fusion#GO:0061025;macromolecule localization#GO:0033036;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;vesicle organization#GO:0016050;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;transport#GO:0006810;intracellular protein transport#GO:0006886 SNARE complex#GO:0031201;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasm#GO:0005737;membrane protein complex#GO:0098796;membrane#GO:0016020;intracellular anatomical structure#GO:0005622 SNARE protein#PC00034 Parkinson disease#P00049>Syntaxin#P01215;Metabotropic glutamate receptor group III pathway#P00039>SNARE Complex#P01042;Nicotinic acetylcholine receptor signaling pathway#P00044>SNARE Complex#P01091;Metabotropic glutamate receptor group II pathway#P00040>SNARE Complex#P01049;Adrenaline and noradrenaline biosynthesis#P00001>SNARE#P00072;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>SNARE Complex#P01079;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>SNARE Complex#P01066;Synaptic vesicle trafficking#P05734>Syntaxin 1/2#P05772 HUMAN|HGNC=4065|UniProtKB=P10253 P10253 GAA PTHR22762:SF92 ALPHA-GLUCOSIDASE LYSOSOMAL ALPHA-GLUCOSIDASE catalytic activity#GO:0003824;glucosidase activity#GO:0015926;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;alpha-glucosidase activity#GO:0090599;hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798 cellular process#GO:0009987;lysosome organization#GO:0007040;glycogen catabolic process#GO:0005980;organelle organization#GO:0006996;energy derivation by oxidation of organic compounds#GO:0015980;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;lytic vacuole organization#GO:0080171;generation of precursor metabolites and energy#GO:0006091;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;glucan catabolic process#GO:0009251;carbohydrate metabolic process#GO:0005975;polysaccharide metabolic process#GO:0005976;catabolic process#GO:0009056;polysaccharide catabolic process#GO:0000272;primary metabolic process#GO:0044238;glucan metabolic process#GO:0044042;cellular component organization#GO:0016043;glycogen metabolic process#GO:0005977;vacuole organization#GO:0007033;carbohydrate catabolic process#GO:0016052;energy reserve metabolic process#GO:0006112 glucosidase#PC00108 HUMAN|HGNC=28558|UniProtKB=Q8N6Q1 Q8N6Q1 TMCO5A PTHR22422:SF7 TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 5B-RELATED TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 5A HUMAN|HGNC=5228|UniProtKB=P25686 P25686 DNAJB2 PTHR45168:SF1 DNAJ HOMOLOG SUBFAMILY B MEMBER 2 DNAJ HOMOLOG SUBFAMILY B MEMBER 2 heat shock protein binding#GO:0031072;protein-folding chaperone binding#GO:0051087;Hsp70 protein binding#GO:0030544;molecular function regulator activity#GO:0098772;ATPase activator activity#GO:0001671;binding#GO:0005488;molecular function activator activity#GO:0140677;protein binding#GO:0005515 protein refolding#GO:0042026;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;protein folding#GO:0006457;biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 chaperone#PC00072 HUMAN|HGNC=2095|UniProtKB=P10909 P10909 CLU PTHR10970:SF1 CLUSTERIN CLUSTERIN binding#GO:0005488;protein binding#GO:0005515 positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;positive regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032436;biological regulation#GO:0065007;regulation of proteasomal protein catabolic process#GO:0061136;positive regulation of macromolecule metabolic process#GO:0010604;regulation of apoptotic process#GO:0042981;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;regulation of catabolic process#GO:0009894;positive regulation of catabolic process#GO:0009896;regulation of biological process#GO:0050789;positive regulation of ubiquitin-dependent protein catabolic process#GO:2000060;regulation of programmed cell death#GO:0043067;positive regulation of proteasomal protein catabolic process#GO:1901800;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of protein metabolic process#GO:0051247;positive regulation of protein catabolic process#GO:0045732;regulation of protein catabolic process#GO:0042176;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434;positive regulation of metabolic process#GO:0009893 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;extracellular region#GO:0005576;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 CCKR signaling map#P06959>CLU#P07069;CCKR signaling map#P06959>CLU#G07284;CCKR signaling map#P06959>CLU#G06991 HUMAN|HGNC=9202|UniProtKB=Q9Y6A1 Q9Y6A1 POMT1 PTHR10050:SF51 DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE PROTEIN O-MANNOSYL-TRANSFERASE 1 transferase#PC00220;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=30629|UniProtKB=Q6PJ21 Q6PJ21 SPSB3 PTHR12245:SF5 SPRY DOMAIN CONTAINING SOCS BOX PROTEIN SPRY DOMAIN-CONTAINING SOCS BOX PROTEIN 3 ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=28837|UniProtKB=Q8WY98 Q8WY98 TMEM234 PTHR28668:SF1 TRANSMEMBRANE PROTEIN 234 TRANSMEMBRANE PROTEIN 234 HUMAN|HGNC=16791|UniProtKB=Q8WW01 Q8WW01 TSEN15 PTHR28582:SF1 TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN15 TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN15 HUMAN|HGNC=28358|UniProtKB=Q8N465 Q8N465 D2HGDH PTHR43716:SF5 D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;catalytic activity#GO:0003824 small molecule metabolic process#GO:0044281;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;carboxylic acid metabolic process#GO:0019752;cellular process#GO:0009987 mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 dehydrogenase#PC00092;oxidoreductase#PC00176 HUMAN|HGNC=1709|UniProtKB=P21926 P21926 CD9 PTHR19282:SF163 TETRASPANIN CD9 ANTIGEN cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=14908|UniProtKB=Q9H3S3 Q9H3S3 TMPRSS5 PTHR24253:SF70 TRANSMEMBRANE PROTEASE SERINE TRANSMEMBRANE PROTEASE SERINE 5 serine-type peptidase activity#GO:0008236;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;serine hydrolase activity#GO:0017171 metabolic process#GO:0008152;proteolysis#GO:0006508;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;protein processing#GO:0016485;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 protein modifying enzyme#PC00260;serine protease#PC00203;protease#PC00190 HUMAN|HGNC=20656|UniProtKB=Q8NC54 Q8NC54 KCT2 PTHR16502:SF0 KERATINOCYTE-ASSOCIATED TRANSMEMBRANE PROTEIN 2 KERATINOCYTE-ASSOCIATED TRANSMEMBRANE PROTEIN 2 HUMAN|HGNC=24132|UniProtKB=Q96LC9 Q96LC9 BMF PTHR32014:SF2 BCL-2-MODIFYING FACTOR BCL-2-MODIFYING FACTOR regulation of cellular process#GO:0050794;positive regulation of programmed cell death#GO:0043068;negative regulation of metabolic process#GO:0009892;regulation of programmed cell death#GO:0043067;regulation of autophagy#GO:0010506;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of catabolic process#GO:0009895;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of apoptotic process#GO:0043065;negative regulation of autophagy#GO:0010507;regulation of catabolic process#GO:0009894;negative regulation of cellular process#GO:0048523;regulation of apoptotic process#GO:0042981 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;myosin complex#GO:0016459;actin cytoskeleton#GO:0015629;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 HUMAN|HGNC=2359|UniProtKB=Q9NZV1 Q9NZV1 CRIM1 PTHR46439:SF1 CYSTEINE-RICH MOTOR NEURON 1 PROTEIN CYSTEINE-RICH MOTOR NEURON 1 PROTEIN HUMAN|HGNC=25108|UniProtKB=Q7Z340 Q7Z340 ZNF551 PTHR24377:SF716 IP01015P-RELATED ZINC FINGER PROTEIN 551 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=16853|UniProtKB=O94829 O94829 IPO13 PTHR12363:SF33 TRANSPORTIN 3 AND IMPORTIN 13 IMPORTIN-13 molecular carrier activity#GO:0140104;nucleocytoplasmic carrier activity#GO:0140142 establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810;protein localization to nucleus#GO:0034504;macromolecule localization#GO:0033036;import into nucleus#GO:0051170;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular localization#GO:0051641;localization#GO:0051179;protein transport#GO:0015031;protein import into nucleus#GO:0006606;nuclear transport#GO:0051169;nucleocytoplasmic transport#GO:0006913;protein localization to organelle#GO:0033365 intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;nucleus#GO:0005634;organelle envelope#GO:0031967;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 transporter#PC00227 HUMAN|HGNC=1186|UniProtKB=Q9NR21 Q9NR21 PARP11 PTHR45740:SF4 POLY [ADP-RIBOSE] POLYMERASE PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP11 NAD+ poly-ADP-ribosyltransferase activity#GO:0003950;catalytic activity#GO:0003824;transferase activity#GO:0016740;pentosyltransferase activity#GO:0016763;glycosyltransferase activity#GO:0016757;catalytic activity, acting on a protein#GO:0140096 metabolic process#GO:0008152;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein modification process#GO:0036211;post-translational protein modification#GO:0043687 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=11037|UniProtKB=P31639 P31639 SLC5A2 PTHR11819:SF145 SOLUTE CARRIER FAMILY 5 SODIUM_GLUCOSE COTRANSPORTER 2 symporter activity#GO:0015293;solute:sodium symporter activity#GO:0015370;monoatomic cation transmembrane transporter activity#GO:0008324;carbohydrate transmembrane transporter activity#GO:0015144;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;solute:monoatomic cation symporter activity#GO:0015294;monoatomic ion transmembrane transporter activity#GO:0015075;sugar transmembrane transporter activity#GO:0051119;sodium ion transmembrane transporter activity#GO:0015081;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873 multicellular organismal process#GO:0032501;carbohydrate transmembrane transport#GO:0034219;import across plasma membrane#GO:0098739;cellular process#GO:0009987;renal system process#GO:0003014;D-glucose transmembrane transport#GO:1904659;system process#GO:0003008;transmembrane transport#GO:0055085;import into cell#GO:0098657;establishment of localization#GO:0051234;renal absorption#GO:0070293;localization#GO:0051179;transport#GO:0006810;carbohydrate transport#GO:0008643 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227;secondary carrier transporter#PC00258 HUMAN|HGNC=7146|UniProtKB=Q7Z4N2 Q7Z4N2 TRPM1 PTHR13800:SF13 TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6 TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 1 passive transmembrane transporter activity#GO:0022803;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic cation channel activity#GO:0005261;metal ion transmembrane transporter activity#GO:0046873;calcium ion transmembrane transporter activity#GO:0015085;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324 monoatomic ion transport#GO:0006811;calcium ion transport#GO:0006816;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=9115|UniProtKB=O15305 O15305 PMM2 PTHR10466:SF2 PHOSPHOMANNOMUTASE PHOSPHOMANNOMUTASE 2 intramolecular transferase activity#GO:0016866;catalytic activity#GO:0003824;intramolecular phosphotransferase activity#GO:0016868;isomerase activity#GO:0016853 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;glycoprotein biosynthetic process#GO:0009101;biosynthetic process#GO:0009058;glycoprotein metabolic process#GO:0009100;monosaccharide metabolic process#GO:0005996;metabolic process#GO:0008152;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;hexose metabolic process#GO:0019318;protein N-linked glycosylation#GO:0006487;primary metabolic process#GO:0044238;carbohydrate metabolic process#GO:0005975;small molecule metabolic process#GO:0044281;protein metabolic process#GO:0019538 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 mutase#PC00160;isomerase#PC00135;metabolite interconversion enzyme#PC00262 Mannose metabolism#P02752>P-Mannose mutase#P03019 HUMAN|HGNC=24530|UniProtKB=Q96B77 Q96B77 TMEM186 PTHR13603:SF1 TRANSMEMBRANE PROTEIN 186 TRANSMEMBRANE PROTEIN 186 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=18451|UniProtKB=Q8NI22 Q8NI22 MCFD2 PTHR23104:SF14 MULTIPLE COAGULATION FACTOR DEFICIENCY PROTEIN 2 NEURAL STEM CELL DERIVED NEURONAL SURVIVAL PROTEIN MULTIPLE COAGULATION FACTOR DEFICIENCY PROTEIN 2 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;membrane protein complex#GO:0098796;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;membrane#GO:0016020 membrane traffic protein#PC00150 HUMAN|HGNC=1708|UniProtKB=A6NJW9 A6NJW9 CD8B2 PTHR11292:SF7 T-CELL SURFACE GLYCOPROTEIN CD8 BETA CHAIN T-CELL SURFACE GLYCOPROTEIN CD8 BETA CHAIN-RELATED immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=16148|UniProtKB=Q9UJA2 Q9UJA2 CRLS1 PTHR14269:SF60 CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED CARDIOLIPIN SYNTHASE (CMP-FORMING) transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, for other substituted phosphate groups#GO:0016780 organophosphate biosynthetic process#GO:0090407;phospholipid metabolic process#GO:0006644;phosphatidylglycerol biosynthetic process#GO:0006655;glycerolipid metabolic process#GO:0046486;phosphatidylglycerol metabolic process#GO:0046471;phospholipid biosynthetic process#GO:0008654;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;glycerophospholipid biosynthetic process#GO:0046474;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;biosynthetic process#GO:0009058;glycerophospholipid metabolic process#GO:0006650;lipid biosynthetic process#GO:0008610;glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 metabolite interconversion enzyme#PC00262;transferase#PC00220 HUMAN|HGNC=26768|UniProtKB=Q8N954 Q8N954 GPATCH11 PTHR21032:SF3 G PATCH DOMAIN-CONTAINING PROTEIN 11 G PATCH DOMAIN-CONTAINING PROTEIN 11 nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170;system process#GO:0003008;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;multicellular organismal process#GO:0032501;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;nervous system process#GO:0050877;nucleic acid biosynthetic process#GO:0141187;sensory perception#GO:0007600;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;sensory perception of light stimulus#GO:0050953;nucleic acid metabolic process#GO:0090304;visual perception#GO:0007601;RNA biosynthetic process#GO:0032774 cytoskeleton#GO:0005856;centrosome#GO:0005813;microtubule organizing center#GO:0005815;membraneless organelle#GO:0043228;membrane-enclosed lumen#GO:0031974;microtubule cytoskeleton#GO:0015630;nucleus#GO:0005634;intracellular membraneless organelle#GO:0043232;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=10381|UniProtKB=P04843 P04843 RPN1 PTHR21049:SF0 RIBOPHORIN I DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 1 biosynthetic process#GO:0009058;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487;glycoprotein biosynthetic process#GO:0009101;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152 membrane#GO:0016020;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;endoplasmic reticulum membrane#GO:0005789;transferase complex#GO:1990234;endoplasmic reticulum#GO:0005783;endoplasmic reticulum protein-containing complex#GO:0140534;organelle membrane#GO:0031090;membrane protein complex#GO:0098796;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;oligosaccharyltransferase complex#GO:0008250;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 transferase#PC00220;glycosyltransferase#PC00111 HUMAN|HGNC=17265|UniProtKB=Q7Z7G0 Q7Z7G0 ABI3BP PTHR23197:SF10 TARSH-RELATED FIBRONECTIN DOMAIN-CONTAINING TARGET OF NESH-SH3 receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;hormone activity#GO:0005179;signaling receptor activator activity#GO:0030546 anatomical structure development#GO:0048856;cellular developmental process#GO:0048869;animal organ development#GO:0048513;mesenchyme development#GO:0060485;animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502;mesenchymal cell differentiation#GO:0048762;cell differentiation#GO:0030154;tissue development#GO:0009888;cell development#GO:0048468;cellular process#GO:0009987 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=21068|UniProtKB=Q7Z6P3 Q7Z6P3 RAB44 PTHR47977:SF72 RAS-RELATED PROTEIN RAB RAS-RELATED PROTEIN RAB-44 ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleotide binding#GO:0000166;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;anion binding#GO:0043168;small molecule binding#GO:0036094;GTPase activity#GO:0003924;ion binding#GO:0043167;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;hydrolase activity, acting on acid anhydrides#GO:0016817;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;nucleoside phosphate binding#GO:1901265;guanyl nucleotide binding#GO:0019001 localization#GO:0051179;vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;transport#GO:0006810;cellular process#GO:0009987 small GTPase#PC00208 HUMAN|HGNC=3693|UniProtKB=Q8N441 Q8N441 FGFRL1 PTHR19890:SF13 FIBROBLAST GROWTH FACTOR RECEPTOR FIBROBLAST GROWTH FACTOR RECEPTOR-LIKE 1 transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity, acting on a protein#GO:0140096;transmembrane receptor protein tyrosine kinase activity#GO:0004714;molecular transducer activity#GO:0060089;kinase activity#GO:0016301;transferase activity#GO:0016740;signaling receptor activity#GO:0038023;fibroblast growth factor binding#GO:0017134;transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;growth factor binding#GO:0019838;protein binding#GO:0005515 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197;tyrosine protein kinase receptor#PC00233 HUMAN|HGNC=7727|UniProtKB=P46934 P46934 NEDD4 PTHR11254:SF282 HECT DOMAIN UBIQUITIN-PROTEIN LIGASE E3 UBIQUITIN-PROTEIN LIGASE NEDD4 molecular function regulator activity#GO:0098772;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;ion channel regulator activity#GO:0099106;ion channel inhibitor activity#GO:0008200;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;channel regulator activity#GO:0016247;molecular function inhibitor activity#GO:0140678;transporter regulator activity#GO:0141108;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746 cellular component organization#GO:0016043;regulation of biological process#GO:0050789;endocytosis#GO:0006897;regulation of cellular component organization#GO:0051128;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell development#GO:0048468;animal gross anatomical part developmental process#GO:0160108;modification-dependent macromolecule catabolic process#GO:0043632;regulation of synapse organization#GO:0050807;protein catabolic process#GO:0030163;generation of neurons#GO:0048699;regulation of biological quality#GO:0065008;neuron development#GO:0048666;neuron projection development#GO:0031175;receptor internalization#GO:0031623;cellular process#GO:0009987;regulation of neuron projection development#GO:0010975;vesicle-mediated transport#GO:0016192;nervous system development#GO:0007399;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;neuron differentiation#GO:0030182;regulation of anatomical structure morphogenesis#GO:0022603;import into cell#GO:0098657;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;neuromuscular junction development#GO:0007528;regulation of dendrite morphogenesis#GO:0048814;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cell junction organization#GO:0034330;regulation of cellular process#GO:0050794;regulation of dendrite development#GO:0050773;catabolic process#GO:0009056;regulation of developmental process#GO:0050793;synapse organization#GO:0050808;anatomical structure development#GO:0048856;regulation of synapse structure or activity#GO:0050803;protein metabolic process#GO:0019538;localization#GO:0051179;system development#GO:0048731;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;regulation of cell projection organization#GO:0031344;transport#GO:0006810;developmental process#GO:0032502;establishment of localization#GO:0051234;cellular developmental process#GO:0048869;regulation of plasma membrane bounded cell projection organization#GO:0120035;macromolecule metabolic process#GO:0043170;neurogenesis#GO:0022008;ubiquitin-dependent protein catabolic process#GO:0006511;receptor-mediated endocytosis#GO:0006898 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Ubiquitin proteasome pathway#P00060>E3#P01490 HUMAN|HGNC=10976|UniProtKB=Q9UI40 Q9UI40 SLC24A2 PTHR10846:SF41 SODIUM/POTASSIUM/CALCIUM EXCHANGER SODIUM_POTASSIUM_CALCIUM EXCHANGER 2 channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;monoatomic cation channel activity#GO:0005261;calcium channel activity#GO:0005262;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;antiporter activity#GO:0015297 intracellular monoatomic cation homeostasis#GO:0030003;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;negative regulation of cellular process#GO:0048523;regulation of synaptic plasticity#GO:0048167;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;establishment of localization#GO:0051234;positive regulation of cellular process#GO:0048522;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;localization#GO:0051179;monoatomic cation transport#GO:0006812;regulation of cell communication#GO:0010646;homeostatic process#GO:0042592;modulation of chemical synaptic transmission#GO:0050804;metal ion transport#GO:0030001;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;chemical homeostasis#GO:0048878;calcium ion transport#GO:0006816;intracellular calcium ion homeostasis#GO:0006874;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;monoatomic ion homeostasis#GO:0050801;monoatomic cation transmembrane transport#GO:0098655;regulation of trans-synaptic signaling#GO:0099177;inorganic ion homeostasis#GO:0098771;regulation of signaling#GO:0023051;calcium ion homeostasis#GO:0055074;positive regulation of synaptic transmission#GO:0050806;negative regulation of signaling#GO:0023057;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;negative regulation of cell communication#GO:0010648;positive regulation of signaling#GO:0023056;transmembrane transport#GO:0055085;regulation of biological process#GO:0050789;intracellular monoatomic ion homeostasis#GO:0006873;calcium ion transmembrane transport#GO:0070588;negative regulation of biological process#GO:0048519 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 secondary carrier transporter#PC00258 HUMAN|HGNC=9249|UniProtKB=Q86W92 Q86W92 PPFIBP1 PTHR12587:SF16 LAR INTERACTING PROTEIN LIP -RELATED PROTEIN LIPRIN-BETA-1 structural molecule activity#GO:0005198;protein complex scaffold activity#GO:0140378 synapse organization#GO:0050808;cellular process#GO:0009987;cellular component organization#GO:0016043;neuromuscular junction development#GO:0007528;cellular component organization or biogenesis#GO:0071840;cell junction organization#GO:0034330 cell junction#GO:0030054;synapse#GO:0045202;cellular anatomical structure#GO:0110165;presynaptic active zone#GO:0048786;presynapse#GO:0098793 scaffold/adaptor protein#PC00226 HUMAN|HGNC=10274|UniProtKB=O75695 O75695 RP2 PTHR15440:SF0 XRP2 PROTEIN PROTEIN XRP2 enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 cellular process#GO:0009987;transport#GO:0006810;Golgi vesicle transport#GO:0048193;localization#GO:0051179;establishment of localization#GO:0051234;vesicle-mediated transport#GO:0016192;post-Golgi vesicle-mediated transport#GO:0006892 cell projection#GO:0042995;plasma membrane#GO:0005886;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;cilium#GO:0005929 GTPase-activating protein#PC00257;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HUMAN|HGNC=2977|UniProtKB=O14717 O14717 TRDMT1 PTHR46098:SF1 TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on RNA#GO:0140098;RNA methyltransferase activity#GO:0008173;tRNA methyltransferase activity#GO:0008175 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 RNA processing factor#PC00147 HUMAN|HGNC=6242|UniProtKB=Q9Y6J6 Q9Y6J6 KCNE2 PTHR15282:SF8 POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY E MEMBER 1, 3 POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY E MEMBER 2 monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;protein binding#GO:0005515;potassium channel regulator activity#GO:0015459;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;binding#GO:0005488;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;channel regulator activity#GO:0016247;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;transmembrane transporter binding#GO:0044325;potassium channel activity#GO:0005267;transporter regulator activity#GO:0141108;molecular function regulator activity#GO:0098772;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;ion channel regulator activity#GO:0099106;passive transmembrane transporter activity#GO:0022803 heart process#GO:0003015;regulation of biological process#GO:0050789;action potential#GO:0001508;muscle system process#GO:0003012;export from cell#GO:0140352;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;cellular process#GO:0009987;regulation of multicellular organismal process#GO:0051239;monoatomic cation transmembrane transport#GO:0098655;cardiac muscle cell action potential involved in contraction#GO:0086002;regulation of membrane potential#GO:0042391;regulation of heart contraction#GO:0008016;striated muscle contraction#GO:0006941;metal ion transport#GO:0030001;actin-mediated cell contraction#GO:0070252;actin filament-based process#GO:0030029;cardiac muscle contraction#GO:0060048;circulatory system process#GO:0003013;monoatomic cation transport#GO:0006812;localization#GO:0051179;actin filament-based movement#GO:0030048;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;multicellular organismal process#GO:0032501;potassium ion transport#GO:0006813;blood circulation#GO:0008015;transport#GO:0006810;muscle contraction#GO:0006936;regulation of system process#GO:0044057;system process#GO:0003008;heart contraction#GO:0060047;establishment of localization#GO:0051234;cardiac muscle cell contraction#GO:0086003 transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;cation channel complex#GO:0034703;voltage-gated potassium channel complex#GO:0008076;plasma membrane#GO:0005886;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;membrane#GO:0016020 voltage-gated ion channel#PC00241 HUMAN|HGNC=6932|UniProtKB=P32245 P32245 MC4R PTHR22750:SF6 G-PROTEIN COUPLED RECEPTOR MELANOCORTIN RECEPTOR 4 transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;signaling receptor activity#GO:0038023;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021 HUMAN|HGNC=652|UniProtKB=P84077 P84077 ARF1 PTHR11711:SF357 ADP RIBOSYLATION FACTOR-RELATED ADP-RIBOSYLATION FACTOR 1 nucleotide binding#GO:0000166;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;guanyl nucleotide binding#GO:0019001;nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;anion binding#GO:0043168 macromolecule localization#GO:0033036;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;intracellular protein localization#GO:0008104;protein transport#GO:0015031 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein#PC00020 Huntington disease#P00029>ARF#P00786;Integrin signalling pathway#P00034>Arf1#P00923 HUMAN|HGNC=13180|UniProtKB=Q9HBF4 Q9HBF4 ZFYVE1 PTHR46624:SF3 AGAP002036-PA ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 1 binding#GO:0005488;anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167;phosphatidylinositol bisphosphate binding#GO:1902936;lipid binding#GO:0008289;phospholipid binding#GO:0005543;phosphatidylinositol phosphate binding#GO:1901981;phosphatidylinositol-3-phosphate binding#GO:0032266 cellular component assembly#GO:0022607;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;lipid storage#GO:0019915;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;lipid droplet organization#GO:0034389;organelle assembly#GO:0070925 intracellular organelle#GO:0043229;lipid droplet#GO:0005811;intracellular membraneless organelle#GO:0043232;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membraneless organelle#GO:0043228 HUMAN|HGNC=33861|UniProtKB=Q7Z3B0 Q7Z3B0 SMIM15 PTHR28644:SF1 SMALL INTEGRAL MEMBRANE PROTEIN 15 SMALL INTEGRAL MEMBRANE PROTEIN 15 HUMAN|HGNC=11557|UniProtKB=Q16559 Q16559 TAL2 PTHR13864:SF21 T-CELL ACUTE LYMPHOCYTIC LEUKEMIA/STEM CELL LEUKEMIA-RELATED T-CELL ACUTE LYMPHOCYTIC LEUKEMIA PROTEIN 2 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=11872|UniProtKB=Q9NZR1 Q9NZR1 TMOD2 PTHR10901:SF15 TROPOMODULIN TROPOMODULIN-2 cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;binding#GO:0005488;protein binding#GO:0005515 cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;striated muscle cell differentiation#GO:0051146;anatomical structure formation involved in morphogenesis#GO:0048646;cellular anatomical entity morphogenesis#GO:0032989;cell differentiation#GO:0030154;cell development#GO:0048468;actomyosin structure organization#GO:0031032;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;muscle system process#GO:0003012;anatomical structure morphogenesis#GO:0009653;striated muscle cell development#GO:0055002;animal gross anatomical part developmental process#GO:0160108;multicellular organismal process#GO:0032501;cellular developmental process#GO:0048869;actin filament organization#GO:0007015;system process#GO:0003008;muscle contraction#GO:0006936;developmental process#GO:0032502;actin cytoskeleton organization#GO:0030036;muscle structure development#GO:0061061;muscle cell development#GO:0055001;muscle cell differentiation#GO:0042692;myofibril assembly#GO:0030239;anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;cellular component assembly involved in morphogenesis#GO:0010927;organelle assembly#GO:0070925;actin filament-based process#GO:0030029 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membraneless organelle#GO:0043228;myofibril#GO:0030016;sarcomere#GO:0030017;contractile muscle fiber#GO:0043292;actin cytoskeleton#GO:0015629;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;supramolecular complex#GO:0099080;organelle#GO:0043226 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=17889|UniProtKB=Q9UBZ4 Q9UBZ4 APEX2 PTHR22748:SF4 AP ENDONUCLEASE DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE 2 DNA endonuclease activity#GO:0004520;DNA exonuclease activity, producing 5'-phosphomonoesters#GO:0016895;nuclease activity#GO:0004518;3'-5'-DNA exonuclease activity#GO:0008296;exonuclease activity#GO:0004527;phosphoric diester hydrolase activity#GO:0008081;catalytic activity, acting on DNA#GO:0140097;phosphoric ester hydrolase activity#GO:0042578;3'-5' exonuclease activity#GO:0008408;DNA exonuclease activity#GO:0004529;hydrolase activity#GO:0016787;endonuclease activity#GO:0004519;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;DNA nuclease activity#GO:0004536 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stress#GO:0006950;nucleic acid metabolic process#GO:0090304;base-excision repair#GO:0006284;primary metabolic process#GO:0044238;nucleobase-containing compound metabolic process#GO:0006139;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;macromolecule metabolic process#GO:0043170 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=29821|UniProtKB=Q9NPH2 Q9NPH2 ISYNA1 PTHR11510:SF5 MYO-INOSITOL-1 PHOSPHATE SYNTHASE INOSITOL-3-PHOSPHATE SYNTHASE 1 catalytic activity#GO:0003824;isomerase activity#GO:0016853 metabolic process#GO:0008152;alcohol metabolic process#GO:0006066;alcohol biosynthetic process#GO:0046165;small molecule biosynthetic process#GO:0044283;cellular process#GO:0009987;small molecule metabolic process#GO:0044281;biosynthetic process#GO:0009058 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 isomerase#PC00135 HUMAN|HGNC=30358|UniProtKB=A0AV96 A0AV96 RBM47 PTHR21245:SF6 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN RNA-BINDING PROTEIN 47 mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 RNA metabolism protein#PC00031 HUMAN|HGNC=12506|UniProtKB=Q9NPG3 Q9NPG3 UBN1 PTHR21669:SF12 CAPZ-INTERACTING PROTEIN AND RELATED PROTEINS UBINUCLEIN-1 cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;chromatin organization#GO:0006325 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 scaffold/adaptor protein#PC00226 HUMAN|HGNC=1950|UniProtKB=P11229 P11229 CHRM1 PTHR24247:SF182 5-HYDROXYTRYPTAMINE RECEPTOR MUSCARINIC ACETYLCHOLINE RECEPTOR M1 G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;neurotransmitter receptor activity#GO:0030594;G protein-coupled amine receptor activity#GO:0008227;molecular transducer activity#GO:0060089;acetylcholine receptor activity#GO:0015464;transmembrane signaling receptor activity#GO:0004888;postsynaptic neurotransmitter receptor activity#GO:0098960 adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway#GO:0007193;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;response to chemical#GO:0042221;acetylcholine receptor signaling pathway#GO:0095500;cellular response to nitrogen compound#GO:1901699;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987;synaptic signaling#GO:0099536;response to nitrogen compound#GO:1901698;cell communication#GO:0007154;response to oxygen-containing compound#GO:1901700;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;trans-synaptic signaling#GO:0099537;signaling#GO:0023052;anterograde trans-synaptic signaling#GO:0098916;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;chemical synaptic transmission#GO:0007268 cellular anatomical structure#GO:0110165;synapse#GO:0045202;cell projection#GO:0042995;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;cell junction#GO:0030054;dendrite#GO:0030425;dendritic tree#GO:0097447 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>mAChR1/3#P01069;Alzheimer disease-amyloid secretase pathway#P00003>Muscarinic acetylcholine receptors#P00083;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GoPCR#P00725;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GqPCR#P00730;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711 HUMAN|HGNC=6823|UniProtKB=Q9UKM7 Q9UKM7 MAN1B1 PTHR11742:SF55 MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED ENDOPLASMIC RETICULUM MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798 macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;response to stress#GO:0006950;cellular process#GO:0009987;response to chemical#GO:0042221;proteasomal protein catabolic process#GO:0010498;response to endoplasmic reticulum stress#GO:0034976;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;protein metabolic process#GO:0019538;ERAD pathway#GO:0036503;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;catabolic process#GO:0009056 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 protein modifying enzyme#PC00260 HUMAN|HGNC=15165|UniProtKB=P0C604 P0C604 OR4A8 PTHR48002:SF161 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 4A5-RELATED molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=14186|UniProtKB=O00110 O00110 OVOL3 PTHR10032:SF220 ZINC FINGER PROTEIN WITH KRAB AND SCAN DOMAINS TRANSCRIPTION FACTOR OVO-LIKE PROTEIN 3-RELATED transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;animal gross anatomical part developmental process#GO:0160108;regulation of RNA metabolic process#GO:0051252;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;epidermal cell differentiation#GO:0009913;epithelial cell differentiation#GO:0030855;tissue development#GO:0009888;regulation of nucleobase-containing compound metabolic process#GO:0019219;epithelium development#GO:0060429;developmental process#GO:0032502;epidermis development#GO:0008544;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=6499|UniProtKB=P11279 P11279 LAMP1 PTHR11506:SF27 LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN 1 establishment of protein localization to organelle#GO:0072594;localization#GO:0051179;establishment of localization#GO:0051234;establishment of protein localization#GO:0045184 late endosome membrane#GO:0031902;lytic vacuole#GO:0000323;vacuolar membrane#GO:0005774;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;membrane#GO:0016020;lysosomal membrane#GO:0005765;cell periphery#GO:0071944;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;late endosome#GO:0005770;plasma membrane#GO:0005886;vacuole#GO:0005773;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;endosome membrane#GO:0010008;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular vesicle#GO:0097708;lytic vacuole membrane#GO:0098852;vesicle#GO:0031982;lysosome#GO:0005764;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=24013|UniProtKB=Q5QJE6 Q5QJE6 DNTTIP2 PTHR21686:SF12 DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2 DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2 nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;RNA biosynthetic process#GO:0032774;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165 HUMAN|HGNC=23444|UniProtKB=Q5VXJ0 Q5VXJ0 LIPK PTHR11005:SF45 LYSOSOMAL ACID LIPASE-RELATED LIPASE MEMBER K hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;lipase activity#GO:0016298;catalytic activity#GO:0003824 lipid metabolic process#GO:0006629;cellular process#GO:0009987;primary metabolic process#GO:0044238;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 hydrolase#PC00121;lipase#PC00143 HUMAN|HGNC=25527|UniProtKB=Q9H8Y5 Q9H8Y5 ANKZF1 PTHR16036:SF2 ANKYRIN REPEAT AND ZINC FINGER DOMAIN-CONTAINING PROTEIN 1 TRNA ENDONUCLEASE ANKZF1 catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;RNA endonuclease activity#GO:0004521;catalytic activity, acting on RNA#GO:0140098;nuclease activity#GO:0004518;RNA nuclease activity#GO:0004540;endonuclease activity#GO:0004519 gene expression#GO:0010467;biosynthetic process#GO:0009058;organelle organization#GO:0006996;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;translational elongation#GO:0006414;macromolecule catabolic process#GO:0009057;catabolic process#GO:0009056;cytoplasmic translation#GO:0002181;protein quality control for misfolded or incompletely synthesized proteins#GO:0006515;protein biosynthetic process#GO:0160307;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;rescue of stalled cytosolic ribosome#GO:0072344;organelle disassembly#GO:1903008;cellular component disassembly#GO:0022411;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;translation#GO:0006412 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=9012|UniProtKB=Q9NZM6 Q9NZM6 PKD2L2 PTHR10877:SF47 POLYCYSTIN FAMILY MEMBER POLYCYSTIN-2-LIKE PROTEIN 2 passive transmembrane transporter activity#GO:0022803;calcium channel activity#GO:0005262;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic cation channel activity#GO:0005261;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085 response to mechanical stimulus#GO:0009612;detection of stimulus#GO:0051606;detection of mechanical stimulus#GO:0050982;response to abiotic stimulus#GO:0009628;response to external stimulus#GO:0009605;response to stimulus#GO:0050896 cellular anatomical structure#GO:0110165;membrane#GO:0016020 ion channel#PC00133 HUMAN|HGNC=16393|UniProtKB=Q9BXL7 Q9BXL7 CARD11 PTHR14559:SF4 CASPASE RECRUITMENT DOMAIN FAMILY CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 11 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;signaling adaptor activity#GO:0035591 positive regulation of immune system process#GO:0002684;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;regulation of canonical NF-kappaB signal transduction#GO:0043122;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of immune response#GO:0050778;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;positive regulation of canonical NF-kappaB signal transduction#GO:0043123;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of immune system process#GO:0002682;signaling#GO:0023052;regulation of cell communication#GO:0010646;regulation of intracellular signal transduction#GO:1902531;regulation of immune response#GO:0050776;regulation of signaling#GO:0023051;cell communication#GO:0007154;positive regulation of signaling#GO:0023056 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=33358|UniProtKB=A6NK44 A6NK44 GLOD5 PTHR21366:SF14 GLYOXALASE FAMILY PROTEIN GLYOXALASE DOMAIN-CONTAINING PROTEIN 5 HUMAN|HGNC=21080|UniProtKB=Q7Z4G4 Q7Z4G4 TRMT11 PTHR13370:SF3 RNA METHYLASE-RELATED TRNA (GUANINE(10)-N(2))-METHYLTRANSFERASE TRMT11 transferase activity, transferring one-carbon groups#GO:0016741;methyltransferase activity#GO:0008168;transferase activity#GO:0016740;catalytic activity#GO:0003824 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 RNA metabolism protein#PC00031;RNA methyltransferase#PC00033 HUMAN|HGNC=21746|UniProtKB=Q8NE35 Q8NE35 CPEB3 PTHR12566:SF7 CYTOPLASMIC POLYADENYLATION ELEMENT BINDING PROTEIN CPEB CYTOPLASMIC POLYADENYLATION ELEMENT-BINDING PROTEIN 3 translation factor activity#GO:0180051;mRNA 3'-UTR binding#GO:0003730;translation regulator activity#GO:0045182;mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;ribonucleoprotein complex binding#GO:0043021;ribosome binding#GO:0043022;protein-containing complex binding#GO:0044877 regulation of cellular component biogenesis#GO:0044087;negative regulation of metabolic process#GO:0009892;regulation of cellular component organization#GO:0051128;regulation of postsynapse organization#GO:0099175;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of biological quality#GO:0065008;nervous system process#GO:0050877;regulation of synapse organization#GO:0050807;negative regulation of translation#GO:0017148;regulation of protein metabolic process#GO:0051246;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of protein metabolic process#GO:0051248;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of synapse structure or activity#GO:0050803;regulation of cell junction assembly#GO:1901888;cognition#GO:0050890;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regulation of synapse assembly#GO:0051963;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;regulation of gene expression#GO:0010468;system process#GO:0003008;regulation of biosynthetic process#GO:0009889;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523 neuron projection#GO:0043005;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;synapse#GO:0045202;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;cell junction#GO:0030054;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 mRNA polyadenylation factor#PC00146 HUMAN|HGNC=2641|UniProtKB=Q9Y6A2 Q9Y6A2 CYP46A1 PTHR24293:SF1 CYTOCHROME P450 FAMILY 46 SUBFAMILY A CHOLESTEROL 24-HYDROXYLASE oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen#GO:0016712;oxidoreductase activity#GO:0016491;monooxygenase activity#GO:0004497;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;heme binding#GO:0020037;tetrapyrrole binding#GO:0046906;binding#GO:0005488 steroid metabolic process#GO:0008202;secondary alcohol metabolic process#GO:1902652;small molecule catabolic process#GO:0044282;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;lipid catabolic process#GO:0016042;cellular process#GO:0009987;primary metabolic process#GO:0044238;steroid catabolic process#GO:0006706;sterol metabolic process#GO:0016125;lipid metabolic process#GO:0006629;cholesterol metabolic process#GO:0008203;metabolic process#GO:0008152;alcohol metabolic process#GO:0006066 oxygenase#PC00177;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=18077|UniProtKB=Q9NPE2 Q9NPE2 NGRN PTHR13475:SF4 NEUGRIN NEUGRIN ribosome assembly#GO:0042255;organelle assembly#GO:0070925;ribosome biogenesis#GO:0042254;mitochondrial ribosome assembly#GO:0061668;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;ribonucleoprotein complex biogenesis#GO:0022613;cellular component assembly#GO:0022607 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=2213|UniProtKB=P12111 P12111 COL6A3 PTHR24020:SF13 COLLAGEN ALPHA COLLAGEN ALPHA-3(VI) CHAIN cellular anatomical structure#GO:0110165;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576 extracellular matrix structural protein#PC00103 Integrin signalling pathway#P00034>Collagen#P00922;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>EMC#P00863 HUMAN|HGNC=7773|UniProtKB=P35240 P35240 NF2 PTHR23281:SF23 MERLIN/MOESIN/EZRIN/RADIXIN MERLIN cell adhesion molecule binding#GO:0050839;cytoskeletal protein binding#GO:0008092;integrin binding#GO:0005178;actin binding#GO:0003779;binding#GO:0005488;signaling receptor binding#GO:0005102;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 regulation of cell communication#GO:0010646;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;regulation of neurogenesis#GO:0050767;regulation of nervous system development#GO:0051960;regulation of cell population proliferation#GO:0042127;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cell development#GO:0060284;positive regulation of cellular process#GO:0048522;regulation of organelle assembly#GO:1902115;negative regulation of cell population proliferation#GO:0008285;regulation of cell differentiation#GO:0045595;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;regulation of cellular component biogenesis#GO:0044087;regulation of hippo signaling#GO:0035330;regulation of cellular component organization#GO:0051128;regulation of multicellular organismal development#GO:2000026;regulation of organelle organization#GO:0033043;regulation of cell shape#GO:0008360;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;negative regulation of biological process#GO:0048519;regulation of biological quality#GO:0065008;regulation of protein localization#GO:0032880;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;regulation of multicellular organismal process#GO:0051239;positive regulation of transport#GO:0051050;positive regulation of biological process#GO:0048518;regulation of localization#GO:0032879;regulation of transport#GO:0051049;regulation of anatomical structure morphogenesis#GO:0022603 plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;cell periphery#GO:0071944;membrane#GO:0016020;cell-cell junction#GO:0005911;adherens junction#GO:0005912;membraneless organelle#GO:0043228;cell junction#GO:0030054;apical part of cell#GO:0045177;cytoskeleton#GO:0005856;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;actin-based cell projection#GO:0098858;actin cytoskeleton#GO:0015629;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;intracellular organelle#GO:0043229;filopodium#GO:0030175 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=19961|UniProtKB=Q9UNK9 Q9UNK9 ANGEL1 PTHR12121:SF28 CARBON CATABOLITE REPRESSOR PROTEIN 4 RNA 2',3'-CYCLIC PHOSPHATASE ANGEL1 nucleic acid binding#GO:0003676;hydrolase activity#GO:0016787;RNA binding#GO:0003723;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;RNA nuclease activity#GO:0004540;3'-5'-RNA exonuclease activity#GO:0000175;mRNA binding#GO:0003729;exonuclease activity#GO:0004527;binding#GO:0005488;nuclease activity#GO:0004518;mRNA 3'-UTR binding#GO:0003730;3'-5' exonuclease activity#GO:0008408;catalytic activity, acting on RNA#GO:0140098;phosphoric ester hydrolase activity#GO:0042578 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;nucleobase-containing compound catabolic process#GO:0034655;mitochondrial RNA processing#GO:0000963;nucleobase-containing compound metabolic process#GO:0006139;mitochondrial RNA metabolic process#GO:0000959;mitochondrial gene expression#GO:0140053;nucleic acid metabolic process#GO:0090304;positive regulation of mRNA catabolic process#GO:0061014;catabolic process#GO:0009056;positive regulation of mRNA metabolic process#GO:1903313;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;mRNA 3'-end processing#GO:0031124;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;positive regulation of metabolic process#GO:0009893;negative regulation of gene expression#GO:0010629;regulation of mRNA catabolic process#GO:0061013;regulation of mRNA stability#GO:0043488;negative regulation of metabolic process#GO:0009892;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;positive regulation of catabolic process#GO:0009896;macromolecule metabolic process#GO:0043170;regulation of catabolic process#GO:0009894;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;nucleic acid catabolic process#GO:0141188;macromolecule biosynthetic process#GO:0009059;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;biosynthetic process#GO:0009058;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA stability#GO:0043487;regulation of RNA metabolic process#GO:0051252;primary metabolic process#GO:0044238;regulation of cellular process#GO:0050794;nuclear-transcribed mRNA poly(A) tail shortening#GO:0000289;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;RNA biosynthetic process#GO:0032774;macromolecule catabolic process#GO:0009057;mRNA destabilization#GO:0061157;regulation of mRNA metabolic process#GO:1903311;RNA 3'-end processing#GO:0031123;RNA destabilization#GO:0050779;mRNA catabolic process#GO:0006402;mRNA processing#GO:0006397;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;gene expression#GO:0010467;positive regulation of macromolecule metabolic process#GO:0010604;mitochondrial RNA 3'-end processing#GO:0000965;RNA processing#GO:0006396;RNA catabolic process#GO:0006401;regulation of biological quality#GO:0065008;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;mRNA metabolic process#GO:0016071 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;intracellular organelle lumen#GO:0070013 mRNA polyadenylation factor#PC00146 HUMAN|HGNC=28641|UniProtKB=Q86UA6 Q86UA6 RPAIN PTHR31742:SF1 RPA-INTERACTING PROTEIN RPAIN RPA-INTERACTING PROTEIN nucleocytoplasmic transport#GO:0006913;cellular localization#GO:0051641;localization#GO:0051179;protein transport#GO:0015031;protein import into nucleus#GO:0006606;nuclear transport#GO:0051169;protein localization to organelle#GO:0033365;intracellular transport#GO:0046907;transport#GO:0006810;intracellular protein transport#GO:0006886;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;intracellular protein localization#GO:0008104;protein localization to nucleus#GO:0034504;import into nucleus#GO:0051170;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=26956|UniProtKB=Q9ULG1 Q9ULG1 INO80 PTHR45685:SF2 HELICASE SRCAP-RELATED CHROMATIN-REMODELING ATPASE INO80 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;ATP-dependent activity#GO:0140657;protein binding#GO:0005515;hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;histone binding#GO:0042393;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111 nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;chromatin remodeling#GO:0006338;cellular response to stress#GO:0033554;response to stress#GO:0006950;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;chromatin organization#GO:0006325;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840 nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;Ino80 complex#GO:0031011;protein-containing complex#GO:0032991;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;chromatin#GO:0000785;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;INO80-type complex#GO:0097346;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ATPase complex#GO:1904949;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;organelle lumen#GO:0043233;SWI/SNF superfamily-type complex#GO:0070603 Wnt signaling pathway#P00057>SWI/SNF#P01435 HUMAN|HGNC=4086|UniProtKB=Q8N1C3 Q8N1C3 GABRG1 PTHR18945:SF93 NEUROTRANSMITTER GATED ION CHANNEL GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT GAMMA-1 monoatomic ion transmembrane transporter activity#GO:0015075;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;monoatomic ion channel activity#GO:0005216;signaling receptor activity#GO:0038023;ligand-gated channel activity#GO:0022834;neurotransmitter receptor activity#GO:0030594;passive transmembrane transporter activity#GO:0022803;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;molecular transducer activity#GO:0060089;channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;transmembrane signaling receptor activity#GO:0004888 anatomical structure development#GO:0048856;cell communication#GO:0007154;localization#GO:0051179;chloride transmembrane transport#GO:1902476;system development#GO:0048731;trans-synaptic signaling#GO:0099537;synapse organization#GO:0050808;cell junction organization#GO:0034330;anterograde trans-synaptic signaling#GO:0098916;chemical synaptic transmission#GO:0007268;monoatomic anion transport#GO:0006820;establishment of localization#GO:0051234;transport#GO:0006810;developmental process#GO:0032502;multicellular organismal process#GO:0032501;monoatomic ion transmembrane transport#GO:0034220;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698;animal gross anatomical part developmental process#GO:0160108;synapse assembly#GO:0007416;signaling#GO:0023052;cellular component organization#GO:0016043;cell junction assembly#GO:0034329;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;chloride transport#GO:0006821;monoatomic anion transmembrane transport#GO:0098656;cellular component assembly#GO:0022607;nervous system development#GO:0007399;synaptic signaling#GO:0099536;cellular component biogenesis#GO:0044085;cellular process#GO:0009987 signaling receptor complex#GO:0043235;neuron projection membrane#GO:0032589;cell junction#GO:0030054;neuron projection#GO:0043005;cell periphery#GO:0071944;cell leading edge#GO:0031252;membrane#GO:0016020;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;plasma membrane region#GO:0098590;protein-containing complex#GO:0032991;leading edge membrane#GO:0031256;dendritic tree#GO:0097447;dendrite#GO:0030425;cell projection membrane#GO:0031253;postsynapse#GO:0098794;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;synapse#GO:0045202;cellular anatomical structure#GO:0110165 ligand-gated ion channel#PC00141 HUMAN|HGNC=19197|UniProtKB=Q7Z7J5 Q7Z7J5 DPPA2 PTHR16073:SF10 DCR DOMAIN-CONTAINING PROTEIN DEVELOPMENTAL PLURIPOTENCY-ASSOCIATED PROTEIN 2 binding#GO:0005488;chromatin binding#GO:0003682 anatomical structure development#GO:0048856;multicellular organismal process#GO:0032501;multicellular organism development#GO:0007275;system development#GO:0048731;developmental process#GO:0032502 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=33749|UniProtKB=Q52MB2 Q52MB2 CCDC184 PTHR31554:SF2 COILED-COIL DOMAIN-CONTAINING PROTEIN 184 COILED-COIL DOMAIN-CONTAINING PROTEIN 184 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=3437|UniProtKB=P28715 P28715 ERCC5 PTHR16171:SF11 DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED DNA EXCISION REPAIR PROTEIN ERCC-5 nuclease activity#GO:0004518;DNA endonuclease activity#GO:0004520;hydrolase activity#GO:0016787;endonuclease activity#GO:0004519;catalytic activity, acting on DNA#GO:0140097;hydrolase activity, acting on ester bonds#GO:0016788;DNA nuclease activity#GO:0004536;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640 macromolecule metabolic process#GO:0043170;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139;nucleotide-excision repair#GO:0006289;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleotide-excision repair complex#GO:0000109;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 DNA metabolism protein#PC00009 HUMAN|HGNC=29191|UniProtKB=Q9UPQ0 Q9UPQ0 LIMCH1 PTHR15551:SF3 LIM DOMAIN ONLY 7 LIM AND CALPONIN HOMOLOGY DOMAINS-CONTAINING PROTEIN 1 protein binding#GO:0005515;binding#GO:0005488;myosin binding#GO:0017022;cytoskeletal protein binding#GO:0008092 positive regulation of organelle organization#GO:0010638;regulation of cell-matrix adhesion#GO:0001952;regulation of cell junction assembly#GO:1901888;positive regulation of cellular component organization#GO:0051130;regulation of cellular process#GO:0050794;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;regulation of cellular component biogenesis#GO:0044087;regulation of stress fiber assembly#GO:0051492;regulation of actin filament bundle assembly#GO:0032231;regulation of organelle organization#GO:0033043;regulation of supramolecular fiber organization#GO:1902903;regulation of biological process#GO:0050789;positive regulation of actin filament bundle assembly#GO:0032233;regulation of actin filament-based process#GO:0032970;regulation of cell adhesion#GO:0030155;positive regulation of cellular component biogenesis#GO:0044089;regulation of actin cytoskeleton organization#GO:0032956;regulation of cell-substrate adhesion#GO:0010810;biological regulation#GO:0065007;regulation of actin filament organization#GO:0110053;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522 intracellular anatomical structure#GO:0005622;actin filament bundle#GO:0032432;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;stress fiber#GO:0001725;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165;actomyosin#GO:0042641;actin cytoskeleton#GO:0015629 actin or actin-binding cytoskeletal protein#PC00041;cytoskeletal protein#PC00085 HUMAN|HGNC=8675|UniProtKB=Q9Y5H5 Q9Y5H5 PCDHA9 PTHR24028:SF133 CADHERIN-87A PROTOCADHERIN ALPHA-9 cell adhesion#GO:0007155;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 cell adhesion molecule#PC00069;cadherin#PC00057 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HUMAN|HGNC=18569|UniProtKB=Q8IUE0 Q8IUE0 TGIF2LY PTHR11850:SF205 HOMEOBOX PROTEIN TRANSCRIPTION FACTORS HOMEOBOX PROTEIN TGIF2LX-RELATED sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700 regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=7544|UniProtKB=Q96S97 Q96S97 MYADM PTHR17068:SF17 MYELOID-ASSOCIATED DIFFERENTIATION MARKER MYADM FAMILY MEMBER MYELOID-ASSOCIATED DIFFERENTIATION MARKER negative regulation of cellular process#GO:0048523;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of cell-cell adhesion#GO:0022408;negative regulation of cell adhesion#GO:0007162;regulation of cell-cell adhesion#GO:0022407;regulation of cellular process#GO:0050794;regulation of cell adhesion#GO:0030155;biological regulation#GO:0065007 plasma membrane#GO:0005886;anchoring junction#GO:0070161;cell junction#GO:0030054;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;cell-cell junction#GO:0005911 HUMAN|HGNC=7462|UniProtKB=P03923 P03923 MT-ND6 PTHR11435:SF1 NADH UBIQUINONE OXIDOREDUCTASE SUBUNIT ND6 NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 6 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 oxidoreductase#PC00176 HUMAN|HGNC=28685|UniProtKB=Q56VL3 Q56VL3 OCIAD2 PTHR13336:SF2 OVARIAN CARCINOMA IMMUNOREACTIVE ANTIGEN OCIA DOMAIN-CONTAINING PROTEIN 2 endomembrane system#GO:0012505;cytoplasm#GO:0005737;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;organelle membrane#GO:0031090;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;organelle envelope#GO:0031967;vesicle#GO:0031982;mitochondrion#GO:0005739;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;intracellular organelle#GO:0043229 membrane traffic protein#PC00150 HUMAN|HGNC=16496|UniProtKB=Q9UKU0 Q9UKU0 ACSL6 PTHR43272:SF54 LONG-CHAIN-FATTY-ACID--COA LIGASE LONG-CHAIN-FATTY-ACID--COA LIGASE 6 ligase activity, forming carbon-sulfur bonds#GO:0016877;catalytic activity#GO:0003824;ligase activity#GO:0016874;ATP-dependent activity#GO:0140657 lipid metabolic process#GO:0006629;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;fatty acid metabolic process#GO:0006631;small molecule metabolic process#GO:0044281;cellular process#GO:0009987;long-chain fatty acid metabolic process#GO:0001676;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238 membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 ligase#PC00142 HUMAN|HGNC=6719|UniProtKB=Q16873 Q16873 LTC4S PTHR10250:SF4 MICROSOMAL GLUTATHIONE S-TRANSFERASE LEUKOTRIENE C4 SYNTHASE glutathione transferase activity#GO:0004364;oxidoreductase activity, acting on peroxide as acceptor#GO:0016684;lyase activity#GO:0016829;carbon-sulfur lyase activity#GO:0016846;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;antioxidant activity#GO:0016209;peroxidase activity#GO:0004601;catalytic activity#GO:0003824;transferase activity#GO:0016740;oxidoreductase activity#GO:0016491 icosanoid biosynthetic process#GO:0046456;biosynthetic process#GO:0009058;icosanoid metabolic process#GO:0006690;small molecule metabolic process#GO:0044281;carboxylic acid biosynthetic process#GO:0046394;cellular process#GO:0009987;carboxylic acid metabolic process#GO:0019752;small molecule biosynthetic process#GO:0044283;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;organelle envelope#GO:0031967 transferase#PC00220 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Lipoxygenase#P00830 HUMAN|HGNC=1766|UniProtKB=Q9ULB5 Q9ULB5 CDH7 PTHR24027:SF91 CADHERIN-23 CADHERIN-7 cell adhesion molecule binding#GO:0050839;binding#GO:0005488;beta-catenin binding#GO:0008013;protein binding#GO:0005515 cellular component organization or biogenesis#GO:0071840;cell-cell junction assembly#GO:0007043;developmental process#GO:0032502;cell-cell junction organization#GO:0045216;cell migration#GO:0016477;cellular component assembly#GO:0022607;cellular process#GO:0009987;cell-cell adhesion#GO:0098609;cellular component biogenesis#GO:0044085;anatomical structure development#GO:0048856;cell adhesion#GO:0007155;cell junction organization#GO:0034330;cell morphogenesis#GO:0000902;cell motility#GO:0048870;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;cell junction assembly#GO:0034329;adherens junction organization#GO:0034332 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane#GO:0016020;cell-cell junction#GO:0005911;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;extrinsic component of plasma membrane#GO:0019897;cell junction#GO:0030054;extrinsic component of membrane#GO:0019898;anchoring junction#GO:0070161;adherens junction#GO:0005912 cadherin#PC00057;cell adhesion molecule#PC00069 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HUMAN|HGNC=24349|UniProtKB=Q7Z3E2 Q7Z3E2 CCDC186 PTHR18911:SF5 CTCL TUMOR ANTIGEN HD-CL-01 COILED-COIL DOMAIN-CONTAINING PROTEIN 186 HUMAN|HGNC=18224|UniProtKB=Q9UGI0 Q9UGI0 ZRANB1 PTHR13367:SF28 UBIQUITIN THIOESTERASE UBIQUITIN THIOESTERASE ZRANB1 catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;cysteine-type peptidase activity#GO:0008234;cysteine-type deubiquitinase activity#GO:0004843;catalytic activity#GO:0003824;K63-linked polyubiquitin modification-dependent protein binding#GO:0070530;polyubiquitin modification-dependent protein binding#GO:0031593;hydrolase activity#GO:0016787;protein binding#GO:0005515;binding#GO:0005488;modification-dependent protein binding#GO:0140030;deubiquitinase activity#GO:0101005 positive regulation of cellular process#GO:0048522;positive regulation of response to stimulus#GO:0048584;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;post-translational protein modification#GO:0043687;regulation of response to stimulus#GO:0048583;positive regulation of canonical Wnt signaling pathway#GO:0090263;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;positive regulation of signal transduction#GO:0009967;protein modification process#GO:0036211;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;regulation of canonical Wnt signaling pathway#GO:0060828;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of Wnt signaling pathway#GO:0030177;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;regulation of biological process#GO:0050789;regulation of Wnt signaling pathway#GO:0030111;protein modification by small protein conjugation or removal#GO:0070647;protein catabolic process#GO:0030163;regulation of signaling#GO:0023051;modification-dependent macromolecule catabolic process#GO:0043632;positive regulation of signaling#GO:0023056 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 protease#PC00190;cysteine protease#PC00081 HUMAN|HGNC=3061|UniProtKB=P23919 P23919 DTYMK PTHR10344:SF9 THYMIDYLATE KINASE THYMIDYLATE KINASE transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleobase-containing compound kinase activity#GO:0019205;phosphotransferase activity, phosphate group as acceptor#GO:0016776 nucleotide biosynthetic process#GO:0009165;organophosphate biosynthetic process#GO:0090407;nucleotide metabolic process#GO:0009117;nucleoside diphosphate metabolic process#GO:0009132;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative biosynthetic process#GO:1901137;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;cellular process#GO:0009987;pyrimidine-containing compound metabolic process#GO:0072527;carbohydrate derivative metabolic process#GO:1901135;organophosphate metabolic process#GO:0019637 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 transferase#PC00220;nucleotide kinase#PC00172;kinase#PC00137 De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>dTMP kinase#P02916 HUMAN|HGNC=18926|UniProtKB=Q3LI77 Q3LI77 KRTAP13-4 PTHR23262:SF238 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 13-4 structural protein#PC00211 HUMAN|HGNC=3602|UniProtKB=Q9UBX5 Q9UBX5 FBLN5 PTHR24034:SF107 EGF-LIKE DOMAIN-CONTAINING PROTEIN FIBULIN-5 cellular process#GO:0009987;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;extracellular matrix assembly#GO:0085029;cellular component assembly#GO:0022607;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;supramolecular fiber organization#GO:0097435;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HUMAN|HGNC=15840|UniProtKB=Q9UMN6 Q9UMN6 KMT2B PTHR45838:SF3 HISTONE-LYSINE-N-METHYLTRANSFERASE 2 KMT2 FAMILY MEMBER HISTONE-LYSINE N-METHYLTRANSFERASE 2B protein methyltransferase activity#GO:0008276;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a protein#GO:0140096;histone methyltransferase activity#GO:0042054;protein-lysine N-methyltransferase activity#GO:0016279;N-methyltransferase activity#GO:0008170;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;lysine N-methyltransferase activity#GO:0016278;histone H3K4 methyltransferase activity#GO:0042800;histone H3 methyltransferase activity#GO:0140938;histone modifying activity#GO:0140993 regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of RNA metabolic process#GO:0051252;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 nuclear protein-containing complex#GO:0140513;histone methyltransferase complex#GO:0035097;transferase complex#GO:1990234;protein-containing complex#GO:0032991;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;methyltransferase complex#GO:0034708;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233 histone modifying enzyme#PC00261;chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=17364|UniProtKB=Q9UBU7 Q9UBU7 DBF4 PTHR15375:SF22 ACTIVATOR OF S-PHASE KINASE-RELATED PROTEIN DBF4 HOMOLOG A kinase activator activity#GO:0019209;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;protein kinase activator activity#GO:0030295;enzyme activator activity#GO:0008047;protein serine/threonine kinase activator activity#GO:0043539;protein kinase regulator activity#GO:0019887;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207 positive regulation of DNA replication#GO:0045740;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cell cycle#GO:0045787;regulation of cell cycle process#GO:0010564;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;regulation of DNA replication#GO:0006275;positive regulation of metabolic process#GO:0009893;regulation of DNA metabolic process#GO:0051052;regulation of DNA-templated DNA replication#GO:0090329;regulation of biological process#GO:0050789;positive regulation of cell cycle process#GO:0090068;positive regulation of DNA metabolic process#GO:0051054;regulation of cell cycle phase transition#GO:1901987;regulation of cell cycle#GO:0051726;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255 nuclear protein-containing complex#GO:0140513;protein kinase complex#GO:1902911;intracellular anatomical structure#GO:0005622;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;transferase complex, transferring phosphorus-containing groups#GO:0061695;transferase complex#GO:1990234;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 kinase activator#PC00138;kinase modulator#PC00140 HUMAN|HGNC=1437|UniProtKB=P01258 P01258 CALCA PTHR10505:SF18 CALCITONIN-RELATED CALCITONIN protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102;G protein-coupled receptor binding#GO:0001664 adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;signal transduction#GO:0007165;biological regulation#GO:0065007;calcium ion homeostasis#GO:0055074;G protein-coupled receptor signaling pathway#GO:0007186;inorganic ion homeostasis#GO:0098771;cell communication#GO:0007154;intracellular monoatomic ion homeostasis#GO:0006873;cellular response to stimulus#GO:0051716;regulation of cytosolic calcium ion concentration#GO:0051480;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;homeostatic process#GO:0042592;signaling#GO:0023052 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 peptide hormone#PC00179 CCKR signaling map#P06959>CALCA#G06988;CCKR signaling map#P06959>CALCA#G07282 HUMAN|HGNC=5360|UniProtKB=P41134 P41134 ID1 PTHR11723:SF4 DNA-BINDING PROTEIN INHIBITOR DNA-BINDING PROTEIN INHIBITOR ID-1 transcription regulator activity#GO:0140110;transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712 nervous system development#GO:0007399;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;multicellular organism development#GO:0007275;neuron differentiation#GO:0030182;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;system development#GO:0048731;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 HUMAN|HGNC=18065|UniProtKB=Q9NSY2 Q9NSY2 STARD5 PTHR46374:SF3 PROTEIN CBG07384 STAR-RELATED LIPID TRANSFER PROTEIN 5 sterol transfer activity#GO:0120015;transporter activity#GO:0005215;steroid binding#GO:0005496;cholesterol transfer activity#GO:0120020;alcohol binding#GO:0043178;molecular carrier activity#GO:0140104;sterol binding#GO:0032934;lipid carrier activity#GO:0005319;small molecule binding#GO:0036094;binding#GO:0005488;lipid transfer activity#GO:0120013;lipid binding#GO:0008289;cholesterol binding#GO:0015485 transport#GO:0006810;lipid localization#GO:0010876;organic hydroxy compound transport#GO:0015850;establishment of localization#GO:0051234;sterol transport#GO:0015918;localization#GO:0051179;cholesterol transport#GO:0030301;macromolecule localization#GO:0033036;lipid transport#GO:0006869 HUMAN|HGNC=8975|UniProtKB=P42336 P42336 PIK3CA PTHR10048:SF107 PHOSPHATIDYLINOSITOL KINASE PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphatidylinositol kinase activity#GO:0052742;lipid kinase activity#GO:0001727;phosphotransferase activity, alcohol group as acceptor#GO:0016773 glycerophospholipid biosynthetic process#GO:0046474;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;biological regulation#GO:0065007;biosynthetic process#GO:0009058;intracellular signaling cassette#GO:0141124;glycerophospholipid metabolic process#GO:0006650;lipid biosynthetic process#GO:0008610;cell migration#GO:0016477;signal transduction#GO:0007165;phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0043491;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;organophosphate metabolic process#GO:0019637;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;organophosphate biosynthetic process#GO:0090407;phosphatidylinositol phosphate biosynthetic process#GO:0046854;phospholipid metabolic process#GO:0006644;signaling#GO:0023052;glycerolipid metabolic process#GO:0046486;response to stimulus#GO:0050896;cell motility#GO:0048870;regulation of cellular process#GO:0050794;phospholipid biosynthetic process#GO:0008654;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793 transferase complex#GO:1990234;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;extrinsic component of membrane#GO:0019898;cell periphery#GO:0071944;membrane#GO:0016020;membrane protein complex#GO:0098796;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 kinase#PC00137 Axon guidance mediated by netrin#P00009>PI3K#P00363;Integrin signalling pathway#P00034>PI3K#P00936;p53 pathway feedback loops 2#P04398>P110alpha#P04657;p53 pathway feedback loops 2#P04398>P110ALPHA#G04707;p53 pathway feedback loops 2#P04398>PI3K#P04661;p53 pathway#P00059>P110alpha#P04633;PDGF signaling pathway#P00047>PI3K#P01168;Apoptosis signaling pathway#P00006>PI3K#P00310;Ras Pathway#P04393>PI3K#P04567;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>PI3K#P00900;Hypoxia response via HIF activation#P00030>PI3K#P00823;Interleukin signaling pathway#P00036>PI3K#P00990;p53 pathway#P00059>PI3K#P04609;Endothelin signaling pathway#P00019>PI3K#P00577;p53 pathway#P00059>p110alpha#G04694;PI3 kinase pathway#P00048>P110ACT#P01177;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>p110alpha#G04676;VEGF signaling pathway#P00056>PI3K#P01413;PI3 kinase pathway#P00048>p110#P01192;FGF signaling pathway#P00021>PI3K#P00640;B cell activation#P00010>PI3K#P00391;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PI3K#P00868;T cell activation#P00053>PI3K#P01322;EGF receptor signaling pathway#P00018>PI3K#P00557;Angiogenesis#P00005>PI3K#P00236;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>P110alpha#P04498 HUMAN|HGNC=15592|UniProtKB=O75177 O75177 SS18L1 PTHR23107:SF21 SYNOVIAL SARCOMA ASSOCIATED SS18 PROTEIN CALCIUM-RESPONSIVE TRANSACTIVATOR transcription coactivator activity#GO:0003713;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 positive regulation of developmental process#GO:0051094;regulation of cell differentiation#GO:0045595;regulation of cell projection organization#GO:0031344;regulation of gene expression#GO:0010468;regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;regulation of cell development#GO:0060284;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cell projection organization#GO:0031346;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;regulation of nervous system development#GO:0051960;regulation of neurogenesis#GO:0050767;regulation of dendrite morphogenesis#GO:0048814;regulation of developmental process#GO:0050793;positive regulation of RNA metabolic process#GO:0051254;positive regulation of neurogenesis#GO:0050769;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of dendrite development#GO:0050773;positive regulation of cell differentiation#GO:0045597;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of anatomical structure morphogenesis#GO:0022603;regulation of neuron projection development#GO:0010975;positive regulation of biological process#GO:0048518;positive regulation of cell development#GO:0010720;regulation of multicellular organismal process#GO:0051239;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of cellular component organization#GO:0051130;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of biological process#GO:0050789;positive regulation of multicellular organismal process#GO:0051240;regulation of multicellular organismal development#GO:2000026;positive regulation of nervous system development#GO:0051962;regulation of cellular component organization#GO:0051128;regulation of transcription by RNA polymerase II#GO:0006357 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 transcription cofactor#PC00217;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=11101|UniProtKB=O60264 O60264 SMARCA5 PTHR10799:SF997 SNF2/RAD54 HELICASE FAMILY SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 5 ATP-dependent activity, acting on DNA#GO:0008094;DNA binding#GO:0003677;ATP-dependent activity#GO:0140657;chromatin binding#GO:0003682;nucleic acid binding#GO:0003676;binding#GO:0005488;catalytic activity, acting on DNA#GO:0140097;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;chromatin organization#GO:0006325;negative regulation of biosynthetic process#GO:0009890;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;epigenetic regulation of gene expression#GO:0040029;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;heterochromatin formation#GO:0031507;cellular component organization or biogenesis#GO:0071840;negative regulation of gene expression, epigenetic#GO:0045814;positive regulation of transcription by RNA polymerase II#GO:0045944;heterochromatin organization#GO:0070828;positive regulation of macromolecule metabolic process#GO:0010604;cellular component assembly#GO:0022607;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043 chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 DNA helicase#PC00011;DNA metabolism protein#PC00009 Wnt signaling pathway#P00057>SWI/SNF#P01435 HUMAN|HGNC=29486|UniProtKB=Q6UWN8 Q6UWN8 SPINK6 PTHR47499:SF6 SERINE PROTEASE INHIBITOR KAZAL-TYPE 7 SPINK7 SERINE PROTEASE INHIBITOR KAZAL-TYPE 6 enzyme regulator activity#GO:0030234;serine-type endopeptidase inhibitor activity#GO:0004867;molecular function inhibitor activity#GO:0140678;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;peptidase regulator activity#GO:0061134;endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772;enzyme inhibitor activity#GO:0004857 negative regulation of cellular process#GO:0048523;regulation of proteolysis#GO:0030162;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;negative regulation of biological process#GO:0048519;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of protein metabolic process#GO:0051248;biological regulation#GO:0065007;negative regulation of metabolic process#GO:0009892 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease inhibitor#PC00191;protein-binding activity modulator#PC00095 HUMAN|HGNC=19888|UniProtKB=Q9H8L6 Q9H8L6 MMRN2 PTHR15427:SF6 EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER MULTIMERIN-2 cell adhesion molecule binding#GO:0050839;cell adhesion mediator activity#GO:0098631;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;binding#GO:0005488;molecular function activator activity#GO:0140677;protein binding#GO:0005515 circulatory system development#GO:0072359;regulation of cellular process#GO:0050794;negative regulation of biological process#GO:0048519;blood vessel morphogenesis#GO:0048514;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;tube morphogenesis#GO:0035239;blood vessel development#GO:0001568;regulation of cell population proliferation#GO:0042127;anatomical structure development#GO:0048856;angiogenesis#GO:0001525;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;cell adhesion#GO:0007155;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;tube development#GO:0035295;negative regulation of cell population proliferation#GO:0008285;cellular process#GO:0009987;multicellular organism development#GO:0007275;anatomical structure formation involved in morphogenesis#GO:0048646;vasculature development#GO:0001944;negative regulation of cellular process#GO:0048523;cell adhesion mediated by integrin#GO:0033627;developmental process#GO:0032502 scaffold/adaptor protein#PC00226 HUMAN|HGNC=6933|UniProtKB=P33032 P33032 MC5R PTHR22750:SF5 G-PROTEIN COUPLED RECEPTOR MELANOCORTIN RECEPTOR 5 transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021 HUMAN|HGNC=4459|UniProtKB=P80108 P80108 GPLD1 PTHR23221:SF7 GLYCOSYLPHOSPHATIDYLINOSITOL PHOSPHOLIPASE D PHOSPHATIDYLINOSITOL-GLYCAN-SPECIFIC PHOSPHOLIPASE D phosphoric ester hydrolase activity#GO:0042578;phosphoric diester hydrolase activity#GO:0008081;hydrolase activity, acting on ester bonds#GO:0016788;phospholipase activity#GO:0120569;catalytic activity#GO:0003824;glycerophospholipase activity#GO:0004620;hydrolase activity#GO:0016787;lipase activity#GO:0016298 macromolecule localization#GO:0033036;response to peptide hormone#GO:0043434;biological regulation#GO:0065007;cellular response to nitrogen compound#GO:1901699;cellular response to insulin stimulus#GO:0032869;transport#GO:0006810;establishment of protein localization to extracellular region#GO:0035592;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;protein localization to extracellular region#GO:0071692;cellular response to stimulus#GO:0051716;response to insulin#GO:0032868;cellular response to peptide hormone stimulus#GO:0071375;regulation of cellular process#GO:0050794;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;response to nitrogen compound#GO:1901698;secretion#GO:0046903;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;localization#GO:0051179;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;establishment of protein localization#GO:0045184;signal transduction#GO:0007165;response to hormone#GO:0009725;response to chemical#GO:0042221;cell surface receptor signaling pathway#GO:0007166;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;export from cell#GO:0140352;signaling#GO:0023052;cellular response to hormone stimulus#GO:0032870;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;insulin receptor signaling pathway#GO:0008286;response to oxygen-containing compound#GO:1901700;cellular response to chemical stimulus#GO:0070887;protein transport#GO:0015031;secretion by cell#GO:0032940;protein secretion#GO:0009306 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 phospholipase#PC00186 Gonadotropin-releasing hormone receptor pathway#P06664>PLD#P06839 HUMAN|HGNC=3267|UniProtKB=P41091 P41091 EIF2S3 PTHR42854:SF19 EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED translation initiation factor activity#GO:0003743;tRNA binding#GO:0000049;RNA binding#GO:0003723;translation factor activity#GO:0180051;binding#GO:0005488;nucleic acid binding#GO:0003676 metabolic process#GO:0008152;protein-containing complex organization#GO:0043933;protein-RNA complex organization#GO:0071826;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular component assembly#GO:0022607;translation#GO:0006412;translational initiation#GO:0006413;cytoplasmic translational initiation#GO:0002183;protein-RNA complex assembly#GO:0022618;protein metabolic process#GO:0019538;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;ribonucleoprotein complex biogenesis#GO:0022613;protein biosynthetic process#GO:0160307;cytoplasmic translation#GO:0002181 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 translation initiation factor#PC00224 HUMAN|HGNC=26079|UniProtKB=Q5VZ89 Q5VZ89 DENND4C PTHR12296:SF17 DENN DOMAIN-CONTAINING PROTEIN 4 DENN DOMAIN-CONTAINING PROTEIN 4C guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695 regulation of response to stimulus#GO:0048583;cellular response to insulin stimulus#GO:0032869;regulation of small GTPase mediated signal transduction#GO:0051056;response to hormone#GO:0009725;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;cellular response to nitrogen compound#GO:1901699;response to chemical#GO:0042221;response to peptide hormone#GO:0043434;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of intracellular signal transduction#GO:1902531;cellular response to chemical stimulus#GO:0070887;regulation of signaling#GO:0023051;response to oxygen-containing compound#GO:1901700;response to nitrogen compound#GO:1901698;response to endogenous stimulus#GO:0009719;cellular response to stimulus#GO:0051716;response to insulin#GO:0032868;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;cellular response to hormone stimulus#GO:0032870;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;cellular response to peptide hormone stimulus#GO:0071375;regulation of cell communication#GO:0010646 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708 guanyl-nucleotide exchange factor#PC00113;protein-binding activity modulator#PC00095 HUMAN|HGNC=53789|UniProtKB=A0A1B0GU71 A0A1B0GU71 CFAP97D2 PTHR33768:SF7 MIP11318P CFAP97 DOMAIN CONTAINING 2 HUMAN|HGNC=26090|UniProtKB=Q4G0X9 Q4G0X9 CCDC40 PTHR16275:SF9 COILED-COIL DOMAIN-CONTAINING PROTEIN 40 COILED-COIL DOMAIN-CONTAINING PROTEIN 40 left/right pattern formation#GO:0060972;morphogenesis of an epithelium#GO:0002009;microtubule-based process#GO:0007017;animal organ development#GO:0048513;embryonic morphogenesis#GO:0048598;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cell projection assembly#GO:0030031;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;embryo development#GO:0009790;determination of bilateral symmetry#GO:0009855;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;heart development#GO:0007507;cilium movement#GO:0003341;microtubule-based transport#GO:0099111;animal gross anatomical part developmental process#GO:0160108;cilium organization#GO:0044782;anatomical structure morphogenesis#GO:0009653;cilium assembly#GO:0060271;cellular component organization#GO:0016043;circulatory system development#GO:0072359;cell projection organization#GO:0030030;transport#GO:0006810;developmental process#GO:0032502;specification of symmetry#GO:0009799;plasma membrane bounded cell projection assembly#GO:0120031;establishment of localization#GO:0051234;plasma membrane bounded cell projection organization#GO:0120036;tube development#GO:0035295;tissue development#GO:0009888;multicellular organismal process#GO:0032501;regionalization#GO:0003002;epithelium development#GO:0060429;microtubule bundle formation#GO:0001578;embryonic organ development#GO:0048568;pattern specification process#GO:0007389;organelle assembly#GO:0070925;axoneme assembly#GO:0035082;system development#GO:0048731;microtubule cytoskeleton organization#GO:0000226;anatomical structure development#GO:0048856;localization#GO:0051179;tissue morphogenesis#GO:0048729;tube morphogenesis#GO:0035239;heart morphogenesis#GO:0003007;determination of left/right symmetry#GO:0007368;microtubule-based movement#GO:0007018;animal organ morphogenesis#GO:0009887 cilium#GO:0005929;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=7568|UniProtKB=P35580 P35580 MYH10 PTHR45615:SF24 MYOSIN HEAVY CHAIN, NON-MUSCLE MYOSIN-10 protein binding#GO:0005515;protein-containing complex binding#GO:0044877;polypeptide conformation or assembly isomerase activity#GO:0120544;binding#GO:0005488;actin binding#GO:0003779;ATP-dependent activity#GO:0140657;actin filament binding#GO:0051015;cytoskeletal motor activity#GO:0003774;isomerase activity#GO:0016853;catalytic activity#GO:0003824;microfilament motor activity#GO:0000146;macromolecular conformation isomerase activity#GO:0120543;cytoskeletal protein binding#GO:0008092 cellular process#GO:0009987;organelle organization#GO:0006996;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;mitotic cell cycle process#GO:1903047;regulation of anatomical structure morphogenesis#GO:0022603;cellular component organization or biogenesis#GO:0071840;cell cycle process#GO:0022402;regulation of cell shape#GO:0008360;cell division#GO:0051301;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;cell cycle#GO:0007049;regulation of developmental process#GO:0050793;actomyosin structure organization#GO:0031032;actin cytoskeleton organization#GO:0030036;mitotic cytokinesis#GO:0000281;mitotic cell cycle#GO:0000278;actin filament-based process#GO:0030029;cytokinesis#GO:0000910;regulation of biological quality#GO:0065008;cytoskeleton-dependent cytokinesis#GO:0061640 organelle#GO:0043226;supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;actin cytoskeleton#GO:0015629;myosin complex#GO:0016459;membraneless organelle#GO:0043228;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 actin or actin-binding cytoskeletal protein#PC00041 Cytoskeletal regulation by Rho GTPase#P00016>Myosin#P00522;Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Myosin#P00867 HUMAN|HGNC=24489|UniProtKB=Q8ND56 Q8ND56 LSM14A PTHR13586:SF2 SCD6 PROTEIN-RELATED PROTEIN LSM14 HOMOLOG A nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;RNA binding#GO:0003723 cytoplasmic stress granule assembly#GO:0034063;cellular component assembly#GO:0022607;cellular process#GO:0009987;P-body assembly#GO:0033962;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular component organization or biogenesis#GO:0071840;organelle assembly#GO:0070925 intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;P-body#GO:0000932 RNA metabolism protein#PC00031 HUMAN|HGNC=21652|UniProtKB=Q86WC4 Q86WC4 OSTM1 PTHR15644:SF3 OSTEOPETROSIS ASSOCIATED TRANSMEMBRANE PROTEIN 1 OSTEOPETROSIS-ASSOCIATED TRANSMEMBRANE PROTEIN 1 myeloid cell differentiation#GO:0030099;cell differentiation#GO:0030154;cell development#GO:0048468;hemopoiesis#GO:0030097;leukocyte differentiation#GO:0002521;cellular process#GO:0009987;anatomical structure development#GO:0048856;cellular developmental process#GO:0048869;osteoclast differentiation#GO:0030316;developmental process#GO:0032502 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 HUMAN|HGNC=9840|UniProtKB=P11234 P11234 RALB PTHR24070:SF199 RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY RAS-RELATED PROTEIN RAL-B hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signaling#GO:0023052;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;Ras protein signal transduction#GO:0007265;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 small GTPase#PC00208 Ras Pathway#P04393>Ral#P04550 HUMAN|HGNC=3054|UniProtKB=Q9NZW4 Q9NZW4 DSPP PTHR47819:SF1 DENTIN SIALOPHOSPHOPROTEIN DENTIN SIALOPHOSPHOPROTEIN binding#GO:0005488;collagen binding#GO:0005518;protein-containing complex binding#GO:0044877 cellular developmental process#GO:0048869;animal organ development#GO:0048513;anatomical structure development#GO:0048856;anatomical structure formation involved in morphogenesis#GO:0048646;animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502;epithelium development#GO:0060429;odontogenesis of dentin-containing tooth#GO:0042475;cell differentiation#GO:0030154;epithelial cell differentiation#GO:0030855;tissue development#GO:0009888;animal organ morphogenesis#GO:0009887;odontogenesis#GO:0042476;anatomical structure morphogenesis#GO:0009653;cellular process#GO:0009987 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=24026|UniProtKB=Q8TDY3 Q8TDY3 ACTRT2 PTHR11937:SF38 ACTIN ACTIN-RELATED PROTEIN T2 structural molecule activity#GO:0005198;structural constituent of cytoskeleton#GO:0005200 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;actin cytoskeleton#GO:0015629;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232 actin and actin related protein#PC00039 HUMAN|HGNC=37249|UniProtKB=Q6PDB4 Q6PDB4 ZNF880 PTHR24377:SF918 IP01015P-RELATED ZINC FINGER PROTEIN 528-RELATED binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=30739|UniProtKB=Q9Y320 Q9Y320 TMX2 PTHR15853:SF2 THIOREDOXIN-RELATED THIOREDOXIN-RELATED TRANSMEMBRANE PROTEIN 2 catalytic activity#GO:0003824;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;disulfide oxidoreductase activity#GO:0015036;oxidoreductase activity#GO:0016491 anatomical structure development#GO:0048856;animal organ development#GO:0048513;multicellular organism development#GO:0007275;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502;multicellular organismal process#GO:0032501;brain development#GO:0007420;central nervous system development#GO:0007417;head development#GO:0060322;nervous system development#GO:0007399 organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle membrane contact site#GO:0044232;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;mitochondria-associated endoplasmic reticulum membrane contact site#GO:0044233;cytoplasm#GO:0005737;membrane#GO:0016020;organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=19695|UniProtKB=Q14512 Q14512 FGFBP1 PTHR15258:SF2 FGF BINDING PROTEIN-RELATED FIBROBLAST GROWTH FACTOR-BINDING PROTEIN 1 growth factor binding#GO:0019838;protein binding#GO:0005515;binding#GO:0005488 cell communication#GO:0007154;signaling#GO:0023052;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;regulation of biological process#GO:0050789;cellular process#GO:0009987 HUMAN|HGNC=24338|UniProtKB=Q96EU7 Q96EU7 C1GALT1C1 PTHR23033:SF2 BETA1,3-GALACTOSYLTRANSFERASE C1GALT1-SPECIFIC CHAPERONE 1 galactosyltransferase activity#GO:0008378;UDP-glycosyltransferase activity#GO:0008194;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757;hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;catalytic activity#GO:0003824 transferase#PC00220 HUMAN|HGNC=10576|UniProtKB=Q9Y240 Q9Y240 CLEC11A PTHR22799:SF1 TETRANECTIN-RELATED C-TYPE LECTIN DOMAIN FAMILY 11 MEMBER A molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;signaling receptor regulator activity#GO:0030545;growth factor activity#GO:0008083;receptor ligand activity#GO:0048018 ossification#GO:0001503;multicellular organismal process#GO:0032501 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HUMAN|HGNC=26979|UniProtKB=Q6P3W2 Q6P3W2 DNAJC24 PTHR45255:SF1 DNAJ HOMOLOG SUBFAMILY C MEMBER 24 DNAJ HOMOLOG SUBFAMILY C MEMBER 24 ferrous iron binding#GO:0008198;molecular function regulator activity#GO:0098772;iron ion binding#GO:0005506;ATPase activator activity#GO:0001671;transition metal ion binding#GO:0046914;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;cation binding#GO:0043169;molecular function activator activity#GO:0140677;metal ion binding#GO:0046872 chaperone#PC00072 HUMAN|HGNC=17181|UniProtKB=Q9NWX5 Q9NWX5 ASB6 PTHR24132:SF24 ANKYRIN REPEAT AND SOCS BOX PROTEIN 6 ANKYRIN REPEAT AND SOCS BOX PROTEIN 6 scaffold/adaptor protein#PC00226 HUMAN|HGNC=23239|UniProtKB=Q8WTR7 Q8WTR7 ZNF473 PTHR24376:SF93 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 473 negative regulation of metabolic process#GO:0009892;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HUMAN|HGNC=25988|UniProtKB=Q9NXF1 Q9NXF1 TEX10 PTHR16056:SF39 REGULATOR OF MICROTUBULE DYNAMICS PROTEIN TESTIS-EXPRESSED PROTEIN 10 membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;transferase complex#GO:1990234;histone methyltransferase complex#GO:0035097;nuclear protein-containing complex#GO:0140513;organelle lumen#GO:0043233;organelle#GO:0043226;methyltransferase complex#GO:0034708;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 microtubule or microtubule-binding cytoskeletal protein#PC00157;non-motor microtubule binding protein#PC00166;cytoskeletal protein#PC00085 HUMAN|HGNC=9188|UniProtKB=P30876 P30876 POLR2B PTHR20856:SF7 DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 catalytic activity, acting on RNA#GO:0140098;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772 DNA-templated transcription initiation#GO:0006352;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;DNA-templated transcription elongation#GO:0006354;transcription initiation at RNA polymerase II promoter#GO:0006367;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;transcription by RNA polymerase II#GO:0006366 protein-containing complex#GO:0032991;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;membrane-enclosed lumen#GO:0031974;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;RNA polymerase II, core complex#GO:0005665;nucleoplasm#GO:0005654;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;membrane-bounded organelle#GO:0043227;RNA polymerase II, holoenzyme#GO:0016591;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695 DNA-directed RNA polymerase#PC00019;RNA metabolism protein#PC00031 HUMAN|HGNC=5036|UniProtKB=Q14103 Q14103 HNRNPD PTHR48033:SF3 RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN D0 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 organelle lumen#GO:0043233;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;chromatin#GO:0000785;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228 RNA metabolism protein#PC00031 HUMAN|HGNC=30767|UniProtKB=Q9Y448 Q9Y448 KNSTRN PTHR31940:SF2 SMALL KINETOCHORE-ASSOCIATED PROTEIN SMALL KINETOCHORE-ASSOCIATED PROTEIN regulation of cell cycle process#GO:0010564;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;cellular process#GO:0009987;organelle organization#GO:0006996;mitotic sister chromatid segregation#GO:0000070;mitotic cell cycle process#GO:1903047;chromosome organization#GO:0051276;microtubule-based process#GO:0007017;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;chromosome segregation#GO:0007059;regulation of cell cycle#GO:0051726;mitotic cell cycle#GO:0000278;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cell cycle process#GO:0022402;mitotic nuclear division#GO:0140014;cell cycle#GO:0007049;sister chromatid segregation#GO:0000819;nuclear chromosome segregation#GO:0098813;cellular component organization#GO:0016043;organelle fission#GO:0048285;microtubule cytoskeleton organization#GO:0000226;nuclear division#GO:0000280 cytoskeleton#GO:0005856;chromosome, centromeric region#GO:0000775;condensed chromosome#GO:0000793;spindle#GO:0005819;centrosome#GO:0005813;microtubule organizing center#GO:0005815;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;microtubule plus-end#GO:0035371;condensed chromosome, centromeric region#GO:0000779;microtubule cytoskeleton#GO:0015630;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232;intracellular organelle#GO:0043229;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687;supramolecular fiber#GO:0099512;chromosome#GO:0005694;microtubule end#GO:1990752;kinetochore#GO:0000776;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitotic spindle#GO:0072686;centriolar satellite#GO:0034451 HUMAN|HGNC=9309|UniProtKB=Q15172 Q15172 PPP2R5A PTHR10257:SF6 SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT ALPHA ISOFORM enzyme activator activity#GO:0008047;phosphatase activator activity#GO:0019211;protein phosphatase regulator activity#GO:0019888;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;phosphatase regulator activity#GO:0019208 cellular process#GO:0009987;cell cycle process#GO:0022402;cellular component organization#GO:0016043;organelle organization#GO:0006996;cell cycle#GO:0007049;chromosome organization#GO:0051276;meiotic sister chromatid cohesion#GO:0051177;sister chromatid cohesion#GO:0007062;cellular component organization or biogenesis#GO:0071840 cytosol#GO:0005829;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;protein serine/threonine phosphatase complex#GO:0008287;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195;protein modifying enzyme#PC00260 FGF signaling pathway#P00021>PP2A#P00629;Wnt signaling pathway#P00057>PP2A#P01438;EGF receptor signaling pathway#P00018>PP2A#P00547 HUMAN|HGNC=23497|UniProtKB=Q6T4P5 Q6T4P5 PLPPR3 PTHR10165:SF14 LIPID PHOSPHATE PHOSPHATASE PHOSPHOLIPID PHOSPHATASE-RELATED PROTEIN TYPE 3 catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787 cellular process#GO:0009987;signal transduction#GO:0007165;organophosphate metabolic process#GO:0019637;biological regulation#GO:0065007;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;lipid modification#GO:0030258;cellular response to stimulus#GO:0051716;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;phospholipid dephosphorylation#GO:0046839;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;signaling#GO:0023052;phospholipid metabolic process#GO:0006644;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;dephosphorylation#GO:0016311;cell communication#GO:0007154 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 phosphatase#PC00181;hydrolase#PC00121 HUMAN|HGNC=6741|UniProtKB=Q9NQ48 Q9NQ48 LZTFL1 PTHR21635:SF0 LEUCINE ZIPPER TRANSCRIPTION FACTOR LIKE LEUCINE ZIPPER TRANSCRIPTION FACTOR-LIKE PROTEIN 1 cilium or flagellum-dependent cell motility#GO:0001539;cilium movement#GO:0003341;regulation of protein localization#GO:0032880;cilium-dependent cell motility#GO:0060285;regulation of biological process#GO:0050789;sperm motility#GO:0097722;negative regulation of biological process#GO:0048519;reproductive process#GO:0022414;cell motility#GO:0048870;microtubule-based movement#GO:0007018;flagellated sperm motility#GO:0030317;regulation of localization#GO:0032879;microtubule-based process#GO:0007017;cellular process#GO:0009987;cilium movement involved in cell motility#GO:0060294;biological regulation#GO:0065007 cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cilium#GO:0005929;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;basic leucine zipper transcription factor#PC00056 HUMAN|HGNC=10885|UniProtKB=Q96FS4 Q96FS4 SIPA1 PTHR15711:SF14 RAP GTPASE-ACTIVATING PROTEIN SIGNAL-INDUCED PROLIFERATION-ASSOCIATED PROTEIN 1 enzyme activator activity#GO:0008047;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 GTPase-activating protein#PC00257;G-protein modulator#PC00022 HUMAN|HGNC=25477|UniProtKB=Q7L5Y6 Q7L5Y6 DET1 PTHR13374:SF3 DET1 HOMOLOG DE-ETIOLATED-1 HOMOLOG DET1 HOMOLOG ubiquitin protein ligase binding#GO:0031625;enzyme-substrate adaptor activity#GO:0140767;molecular adaptor activity#GO:0060090;ubiquitin-like protein ligase binding#GO:0044389;protein binding#GO:0005515;ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme binding#GO:0019899;protein-macromolecule adaptor activity#GO:0030674;binding#GO:0005488 post-translational protein modification#GO:0043687;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of catabolic process#GO:0009896;macromolecule metabolic process#GO:0043170;regulation of catabolic process#GO:0009894;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;protein modification process#GO:0036211;primary metabolic process#GO:0044238;positive regulation of ubiquitin-dependent protein catabolic process#GO:2000060;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434;regulation of protein catabolic process#GO:0042176;positive regulation of protein catabolic process#GO:0045732;positive regulation of macromolecule metabolic process#GO:0010604;regulation of proteasomal protein catabolic process#GO:0061136;protein ubiquitination#GO:0016567;positive regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032436;regulation of protein metabolic process#GO:0051246;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;metabolic process#GO:0008152;positive regulation of proteasomal protein catabolic process#GO:1901800;protein modification by small protein conjugation#GO:0032446;regulation of biological process#GO:0050789;positive regulation of metabolic process#GO:0009893;protein modification by small protein conjugation or removal#GO:0070647;positive regulation of protein metabolic process#GO:0051247 intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cullin-RING ubiquitin ligase complex#GO:0031461;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=30245|UniProtKB=Q9BXC1 Q9BXC1 GPR174 PTHR24232:SF86 G-PROTEIN COUPLED RECEPTOR G PROTEIN-COUPLED RECEPTOR 174-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=28945|UniProtKB=Q15061 Q15061 WDR43 PTHR44267:SF1 WD REPEAT-CONTAINING PROTEIN 43 WD REPEAT-CONTAINING PROTEIN 43 ribosomal small subunit biogenesis#GO:0042274;metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;maturation of SSU-rRNA#GO:0030490;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;ribonucleoprotein complex biogenesis#GO:0022613 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974 HUMAN|HGNC=17165|UniProtKB=Q9UBB9 Q9UBB9 TFIP11 PTHR23329:SF1 TUFTELIN-INTERACTING PROTEIN 11-RELATED TUFTELIN-INTERACTING PROTEIN 11 mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;protein-RNA complex organization#GO:0071826;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-containing complex organization#GO:0043933;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;protein-containing complex disassembly#GO:0032984;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;cellular component disassembly#GO:0022411;RNA metabolic process#GO:0016070 organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;U2-type spliceosomal complex#GO:0005684;spliceosomal complex#GO:0005681;post-mRNA release spliceosomal complex#GO:0071014;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229 RNA processing factor#PC00147;RNA splicing factor#PC00148 HUMAN|HGNC=7996|UniProtKB=Q16656 Q16656 NRF1 PTHR20338:SF8 NUCLEAR RESPIRATORY FACTOR 1 NUCLEAR RESPIRATORY FACTOR 1 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218 HUMAN|HGNC=10789|UniProtKB=Q16629 Q16629 SRSF7 PTHR23147:SF288 SERINE/ARGININE RICH SPLICING FACTOR SERINE_ARGININE-RICH SPLICING FACTOR 7 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear speck#GO:0016607;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;membraneless organelle#GO:0043228;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;nuclear body#GO:0016604;intracellular membraneless organelle#GO:0043232;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770 RNA processing factor#PC00147;RNA splicing factor#PC00148;RNA metabolism protein#PC00031 HUMAN|HGNC=6254|UniProtKB=Q8NCM2 Q8NCM2 KCNH5 PTHR10217:SF533 VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL VOLTAGE-GATED DELAYED RECTIFIER POTASSIUM CHANNEL KCNH5 potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;potassium channel activity#GO:0005267;monoatomic cation channel activity#GO:0005261;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated monoatomic ion channel activity#GO:0005244;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;transporter activity#GO:0005215 potassium ion transmembrane transport#GO:0071805;metal ion transport#GO:0030001;biological regulation#GO:0065007;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813;cellular process#GO:0009987;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;regulation of membrane potential#GO:0042391;transport#GO:0006810 cation channel complex#GO:0034703;voltage-gated potassium channel complex#GO:0008076;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702 ion channel#PC00133;transporter#PC00227 HUMAN|HGNC=17807|UniProtKB=Q9H9P2 Q9H9P2 CHODL PTHR14789:SF1 CHONDROLECTIN VARIANT CHODLFDELTAE. CHONDROLECTIN positive regulation of cellular component organization#GO:0051130;positive regulation of cell projection organization#GO:0031346;positive regulation of axonogenesis#GO:0050772;regulation of nervous system development#GO:0051960;regulation of biological process#GO:0050789;positive regulation of multicellular organismal process#GO:0051240;regulation of multicellular organismal development#GO:2000026;regulation of neurogenesis#GO:0050767;regulation of developmental process#GO:0050793;positive regulation of neurogenesis#GO:0050769;positive regulation of nervous system development#GO:0051962;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;positive regulation of developmental process#GO:0051094;regulation of cell differentiation#GO:0045595;positive regulation of cell differentiation#GO:0045597;regulation of cell projection organization#GO:0031344;regulation of axonogenesis#GO:0050770;regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of anatomical structure morphogenesis#GO:0022603;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of neuron projection development#GO:0010975;regulation of cell development#GO:0060284;biological regulation#GO:0065007;regulation of multicellular organismal process#GO:0051239;positive regulation of cell development#GO:0010720 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=2328|UniProtKB=P50416 P50416 CPT1A PTHR22589:SF74 CARNITINE O-ACYLTRANSFERASE CARNITINE O-PALMITOYLTRANSFERASE 1, LIVER ISOFORM catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;palmitoyltransferase activity#GO:0016409 small molecule metabolic process#GO:0044281;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;modified amino acid metabolic process#GO:0006575;primary metabolic process#GO:0044238;carnitine metabolic process#GO:0009437;cellular process#GO:0009987;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;fatty acid metabolic process#GO:0006631;lipid metabolic process#GO:0006629 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 metabolite interconversion enzyme#PC00262;acyltransferase#PC00042 HUMAN|HGNC=2549|UniProtKB=Q92879 Q92879 CELF1 PTHR24012:SF686 RNA BINDING PROTEIN CUGBP ELAV-LIKE FAMILY MEMBER 1 RNA binding#GO:0003723;mRNA 3'-UTR binding#GO:0003730;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488 cellular component biogenesis#GO:0044085;mRNA processing#GO:0006397;cellular process#GO:0009987;gene expression#GO:0010467;cellular component assembly#GO:0022607;RNA processing#GO:0006396;mRNA splice site recognition#GO:0006376;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;protein-RNA complex organization#GO:0071826;regulation of mRNA metabolic process#GO:1903311;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;protein-containing complex assembly#GO:0065003;mRNA splicing, via spliceosome#GO:0000398;ribonucleoprotein complex biogenesis#GO:0022613;mRNA metabolic process#GO:0016071;spliceosomal complex assembly#GO:0000245;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;regulation of alternative mRNA splicing, via spliceosome#GO:0000381;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;macromolecule biosynthetic process#GO:0009059;regulation of mRNA processing#GO:0050684;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA splicing#GO:0043484;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulation of gene expression#GO:0010468;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;RNA biosynthetic process#GO:0032774;RNA splicing, via transesterification reactions#GO:0000375;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;protein-RNA complex assembly#GO:0022618;regulation of RNA metabolic process#GO:0051252 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904 RNA metabolism protein#PC00031 HUMAN|HGNC=16046|UniProtKB=Q53HI1 Q53HI1 UNC50 PTHR12841:SF6 PROTEIN UNC-50 HOMOLOG PROTEIN UNC-50 HOMOLOG membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=5594|UniProtKB=P0DP03 P0DP03 IGHV3-30-5 PTHR23266:SF241 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 3-30-RELATED antigen binding#GO:0003823;binding#GO:0005488 immune effector process#GO:0002252;immune system process#GO:0002376;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449;immune response#GO:0006955;adaptive immune response#GO:0002250;response to stimulus#GO:0050896 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=12879|UniProtKB=P21506 P21506 ZNF10 PTHR24381:SF124 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 10 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=6693|UniProtKB=Q9NZR2 Q9NZR2 LRP1B PTHR22722:SF5 LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1B binding#GO:0005488;hormone binding#GO:0042562 receptor-mediated endocytosis#GO:0006898;localization#GO:0051179;import into cell#GO:0098657;establishment of localization#GO:0051234;transport#GO:0006810;vesicle-mediated transport#GO:0016192;endocytosis#GO:0006897;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane region#GO:0098590;cell periphery#GO:0071944;membrane#GO:0016020;apical plasma membrane#GO:0016324;signaling receptor complex#GO:0043235;apical part of cell#GO:0045177 Alzheimer disease-presenilin pathway#P00004>LRP transmembrane fragment#P00152;Alzheimer disease-presenilin pathway#P00004>LRP#P00150;Alzheimer disease-presenilin pathway#P00004>LRP intracellular fragment#P00173;Alzheimer disease-presenilin pathway#P00004>LRP N-terminal fragment#P00169;Alzheimer disease-presenilin pathway#P00004>LRP C-terminal fragment#P00112 HUMAN|HGNC=3763|UniProtKB=P17948 P17948 FLT1 PTHR24416:SF390 TYROSINE-PROTEIN KINASE RECEPTOR VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 1 catalytic activity, acting on a protein#GO:0140096;transmembrane receptor protein kinase activity#GO:0019199;protein tyrosine kinase activity#GO:0004713;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;transmembrane receptor protein tyrosine kinase activity#GO:0004714;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transferase activity#GO:0016740;kinase activity#GO:0016301;protein binding#GO:0005515;growth factor binding#GO:0019838;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888 positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;tube morphogenesis#GO:0035239;blood vessel development#GO:0001568;regulation of cellular process#GO:0050794;cell motility#GO:0048870;positive regulation of cell communication#GO:0010647;regulation of cell communication#GO:0010646;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;regulation of cell motility#GO:2000145;regulation of cell population proliferation#GO:0042127;cell communication#GO:0007154;system development#GO:0048731;positive regulation of cell migration#GO:0030335;positive regulation of cellular process#GO:0048522;multicellular organismal process#GO:0032501;cell migration#GO:0016477;positive regulation of response to stimulus#GO:0048584;tube development#GO:0035295;regulation of locomotion#GO:0040012;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of response to stimulus#GO:0048583;regulation of cell migration#GO:0030334;developmental process#GO:0032502;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of MAPK cascade#GO:0043410;positive regulation of locomotion#GO:0040017;blood vessel morphogenesis#GO:0048514;positive regulation of cell population proliferation#GO:0008284;vascular endothelial growth factor receptor signaling pathway#GO:0048010;positive regulation of cell motility#GO:2000147;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;response to stimulus#GO:0050896;circulatory system development#GO:0072359;signaling#GO:0023052;regulation of intracellular signal transduction#GO:1902531;animal gross anatomical part developmental process#GO:0160108;sprouting angiogenesis#GO:0002040;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;angiogenesis#GO:0001525;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cell surface receptor signaling pathway#GO:0007166;regulation of MAPK cascade#GO:0043408;multicellular organism development#GO:0007275;anatomical structure formation involved in morphogenesis#GO:0048646;vasculature development#GO:0001944 membrane#GO:0016020;signaling receptor complex#GO:0043235;cell periphery#GO:0071944;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=8598|UniProtKB=Q8TE04 Q8TE04 PANK1 PTHR12280:SF23 PANTOTHENATE KINASE PANTOTHENATE KINASE 1 phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740 purine-containing compound metabolic process#GO:0072521;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;purine-containing compound biosynthetic process#GO:0072522;organophosphate biosynthetic process#GO:0090407;cellular process#GO:0009987;sulfur compound metabolic process#GO:0006790;organophosphate metabolic process#GO:0019637;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;nucleoside phosphate biosynthetic process#GO:1901293 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 metabolite interconversion enzyme#PC00262;kinase#PC00137 Coenzyme A biosynthesis#P02736>Pantothenate kinase#P02885 HUMAN|HGNC=26273|UniProtKB=Q9H5H4 Q9H5H4 ZNF768 PTHR24381:SF436 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 768 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=21101|UniProtKB=O60888 O60888 CUTA PTHR23419:SF1 DIVALENT CATION TOLERANCE CUTA-RELATED PROTEIN CUTA cation binding#GO:0043169;metal ion binding#GO:0046872;transition metal ion binding#GO:0046914;ion binding#GO:0043167;binding#GO:0005488;copper ion binding#GO:0005507;small molecule binding#GO:0036094 primary active transporter#PC00068 HUMAN|HGNC=5022|UniProtKB=Q9Y261 Q9Y261 FOXA2 PTHR11829:SF167 FORKHEAD BOX PROTEIN HEPATOCYTE NUCLEAR FACTOR 3-BETA sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;cellular process#GO:0009987;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;developmental process#GO:0032502 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 winged helix/forkhead transcription factor#PC00246;gene-specific transcriptional regulator#PC00264;helix-turn-helix transcription factor#PC00116 HUMAN|Ensembl=ENSG00000283738.3|UniProtKB=A0AAG2TG10 A0AAG2TG10 NPIPB3 PTHR15438:SF5 NUCLEAR PORE COMPLEX INTERACTING PROTEIN NUCLEAR PORE COMPLEX INTERACTING PROTEIN FAMILY MEMBER B3-RELATED HUMAN|HGNC=11438|UniProtKB=Q13277 Q13277 STX3 PTHR19957:SF34 SYNTAXIN SYNTAXIN-3 SNAP receptor activity#GO:0005484;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 localization#GO:0051179;secretion#GO:0046903;localization within membrane#GO:0051668;protein localization to cell junction#GO:1902414;vesicle fusion#GO:0006906;vesicle-mediated transport to the plasma membrane#GO:0098876;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;transport#GO:0006810;regulation of postsynaptic membrane neurotransmitter receptor levels#GO:0099072;intracellular transport#GO:0046907;membrane organization#GO:0061024;biological regulation#GO:0065007;macromolecule localization#GO:0033036;membrane fusion#GO:0061025;secretion by cell#GO:0032940;regulation of biological quality#GO:0065008;protein transport#GO:0015031;cellular localization#GO:0051641;export from cell#GO:0140352;protein localization to membrane#GO:0072657;cellular component organization#GO:0016043;exocytosis#GO:0006887;neurotransmitter receptor transport to postsynaptic membrane#GO:0098969;vesicle organization#GO:0016050;cellular component organization or biogenesis#GO:0071840;protein localization to synapse#GO:0035418;intracellular protein transport#GO:0006886;protein localization to cell periphery#GO:1990778;organelle membrane fusion#GO:0090174;organelle fusion#GO:0048284;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;organelle organization#GO:0006996;establishment of protein localization to membrane#GO:0090150 cell junction#GO:0030054;intracellular anatomical structure#GO:0005622;membrane protein complex#GO:0098796;membrane#GO:0016020;postsynapse#GO:0098794;cell periphery#GO:0071944;SNARE complex#GO:0031201;protein-containing complex#GO:0032991;synapse#GO:0045202;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cytoplasm#GO:0005737 SNARE protein#PC00034 5HT3 type receptor mediated signaling pathway#P04375>SNARE Complex#P04423;Beta3 adrenergic receptor signaling pathway#P04379>SNARE Complex#P04447;Beta2 adrenergic receptor signaling pathway#P04378>SNARE Complex#P04442;Dopamine receptor mediated signaling pathway#P05912>SNARE Complex#P05956;Opioid prodynorphin pathway#P05916>SNARE Complex#P05996;Opioid proenkephalin pathway#P05915>SNARE Complex#P05986;5HT2 type receptor mediated signaling pathway#P04374>SNARE Complex#P04415;5HT1 type receptor mediated signaling pathway#P04373>SNARE Complex#P04405;Beta1 adrenergic receptor signaling pathway#P04377>SNARE Complex#P04435;5HT4 type receptor mediated signaling pathway#P04376>SNARE Complex#P04428;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>SNARE Complex#P01079;Nicotinic acetylcholine receptor signaling pathway#P00044>SNARE Complex#P01091;Cortocotropin releasing factor receptor signaling pathway#P04380>SNARE Complex#P04457;Oxytocin receptor mediated signaling pathway#P04391>SNARE Complex#P04532;Thyrotropin-releasing hormone receptor signaling pathway#P04394>SNARE Complex#P04582;Opioid proopiomelanocortin pathway#P05917>SNARE Complex#P06005 HUMAN|HGNC=17171|UniProtKB=Q96JB6 Q96JB6 LOXL4 PTHR45817:SF5 LYSYL OXIDASE-LIKE-RELATED LYSYL OXIDASE HOMOLOG 4 catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491 external encapsulating structure organization#GO:0045229;cellular component organization or biogenesis#GO:0071840;collagen fibril organization#GO:0030199;extracellular matrix organization#GO:0030198;cellular process#GO:0009987;extracellular structure organization#GO:0043062;cellular component organization#GO:0016043 external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 oxidoreductase#PC00176;oxidase#PC00175 HUMAN|HGNC=24336|UniProtKB=Q8IYJ1 Q8IYJ1 CPNE9 PTHR10857:SF112 COPINE COPINE-9 phospholipid binding#GO:0005543;binding#GO:0005488;lipid binding#GO:0008289 response to metal ion#GO:0010038;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cellular response to chemical stimulus#GO:0070887;response to calcium ion#GO:0051592;response to chemical#GO:0042221;response to stimulus#GO:0050896 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 calcium-binding protein#PC00060 HUMAN|HGNC=9076|UniProtKB=O60240 O60240 PLIN1 PTHR47138:SF1 PERILIPIN-1 PERILIPIN-1 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 catabolic process#GO:0009056;lipid catabolic process#GO:0016042;cellular process#GO:0009987;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;primary metabolic process#GO:0044238 lipid droplet#GO:0005811;intracellular membraneless organelle#GO:0043232;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229 HUMAN|HGNC=6315|UniProtKB=P50053 P50053 KHK PTHR43085:SF55 HEXOKINASE FAMILY MEMBER KETOHEXOKINASE phosphotransferase activity, alcohol group as acceptor#GO:0016773;carbohydrate kinase activity#GO:0019200;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 hexose metabolic process#GO:0019318;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;small molecule metabolic process#GO:0044281;regulation of carbohydrate biosynthetic process#GO:0043255;carbohydrate metabolic process#GO:0005975;monosaccharide metabolic process#GO:0005996;regulation of carbohydrate metabolic process#GO:0006109;metabolic process#GO:0008152;regulation of glycogen biosynthetic process#GO:0005979;regulation of biosynthetic process#GO:0009889;regulation of polysaccharide biosynthetic process#GO:0032885;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;biological regulation#GO:0065007;regulation of polysaccharide metabolic process#GO:0032881 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 transferase#PC00220;carbohydrate kinase#PC00065;metabolite interconversion enzyme#PC00262 Fructose galactose metabolism#P02744>Ketohexokinase#P02963 HUMAN|HGNC=9394|UniProtKB=Q9NRD5 Q9NRD5 PICK1 PTHR12141:SF1 ARFAPTIN-RELATED PRKCA-BINDING PROTEIN molecular sensor activity#GO:0140299;molecular function regulator activity#GO:0098772 protein localization to membrane#GO:0072657;cellular component organization#GO:0016043;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;regulation of cellular component organization#GO:0051128;regulation of receptor-mediated endocytosis#GO:0048259;neuron projection organization#GO:0106027;cell projection organization#GO:0030030;receptor clustering#GO:0043113;positive regulation of cellular component organization#GO:0051130;cellular localization#GO:0051641;protein transport#GO:0015031;positive regulation of biological process#GO:0048518;positive regulation of transport#GO:0051050;dendritic spine organization#GO:0097061;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;regulation of actin cytoskeleton organization#GO:0032956;regulation of endocytosis#GO:0030100;intracellular protein transport#GO:0006886;cellular component organization or biogenesis#GO:0071840;regulation of localization#GO:0032879;regulation of transport#GO:0051049;regulation of supramolecular fiber organization#GO:1902903;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794;cell junction organization#GO:0034330;postsynapse organization#GO:0099173;synapse organization#GO:0050808;localization within membrane#GO:0051668;localization#GO:0051179;macromolecule localization#GO:0033036;positive regulation of cellular process#GO:0048522;regulation of actin filament organization#GO:0110053;positive regulation of endocytosis#GO:0045807;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;regulation of actin nucleation#GO:0051125;intracellular transport#GO:0046907;regulation of actin filament-based process#GO:0032970;transport#GO:0006810;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104 Golgi apparatus#GO:0005794;organelle membrane#GO:0031090;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;neuron to neuron synapse#GO:0098984;endomembrane system#GO:0012505;transport vesicle#GO:0030133;postsynaptic specialization#GO:0099572;postsynaptic density#GO:0014069;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;synaptic vesicle#GO:0008021;vesicle#GO:0031982;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;asymmetric synapse#GO:0032279;cell junction#GO:0030054;presynapse#GO:0098793;neuron projection#GO:0043005;secretory vesicle#GO:0099503;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;trans-Golgi network membrane#GO:0032588;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;organelle subcompartment#GO:0031984;postsynapse#GO:0098794;intracellular vesicle#GO:0097708;cell projection#GO:0042995;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226 vesicle coat protein#PC00235 Ionotropic glutamate receptor pathway#P00037>PICK#P01012 HUMAN|HGNC=3314|UniProtKB=Q14576 Q14576 ELAVL3 PTHR10352:SF15 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G ELAV-LIKE PROTEIN 3 ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 translational protein#PC00263;translation factor#PC00223;translation initiation factor#PC00224 HUMAN|HGNC=20374|UniProtKB=Q9H4S2 Q9H4S2 GSX1 PTHR24339:SF29 HOMEOBOX PROTEIN EMX-RELATED GS HOMEOBOX 1 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 positive regulation of macromolecule metabolic process#GO:0010604;head development#GO:0060322;nervous system development#GO:0007399;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;animal organ development#GO:0048513;multicellular organism development#GO:0007275;positive regulation of transcription by RNA polymerase II#GO:0045944;neuron differentiation#GO:0030182;central nervous system development#GO:0007417;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of biological process#GO:0050789;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;positive regulation of DNA-templated transcription#GO:0045893;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;brain development#GO:0007420;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;developmental process#GO:0032502;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 homeodomain transcription factor#PC00119 HUMAN|HGNC=1912|UniProtKB=P28329 P28329 CHAT PTHR22589:SF14 CARNITINE O-ACYLTRANSFERASE CHOLINE O-ACETYLTRANSFERASE catalytic activity#GO:0003824;transferase activity#GO:0016740;acetyltransferase activity#GO:0016407;acyltransferase activity#GO:0016746;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 metabolic process#GO:0008152;neuromuscular synaptic transmission#GO:0007274;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;chemical synaptic transmission#GO:0007268;synaptic signaling#GO:0099536;regulation of biological process#GO:0050789;cellular process#GO:0009987;anterograde trans-synaptic signaling#GO:0098916;signaling#GO:0023052;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;biosynthetic process#GO:0009058 neuron projection#GO:0043005;cell projection#GO:0042995;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165 acyltransferase#PC00042;metabolite interconversion enzyme#PC00262 Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>CAT#P01076;Nicotinic acetylcholine receptor signaling pathway#P00044>CAT#P01087;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>CAT#P01063 HUMAN|HGNC=17276|UniProtKB=O43414 O43414 ERI3 PTHR23044:SF85 3'-5' EXONUCLEASE ERI1-RELATED ERI1 EXORIBONUCLEASE 3 exonuclease activity#GO:0004527;3'-5'-RNA exonuclease activity#GO:0000175;hydrolase activity#GO:0016787;nuclease activity#GO:0004518;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity, acting on ester bonds#GO:0016788;3'-5' exonuclease activity#GO:0008408;catalytic activity, acting on RNA#GO:0140098;RNA nuclease activity#GO:0004540 regulation of gene expression#GO:0010468;positive regulation of gene expression#GO:0010628;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;negative regulation of cellular process#GO:0048523;rRNA metabolic process#GO:0016072;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;biological regulation#GO:0065007;macromolecule biosynthetic process#GO:0009059;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;rRNA processing#GO:0006364;positive regulation of biosynthetic process#GO:0009891;regulation of chromatin organization#GO:1902275;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of cellular component organization#GO:0051129;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA 3'-end processing#GO:0031123;cellular component organization or biogenesis#GO:0071840;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA processing#GO:0006396;gene expression#GO:0010467;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;cellular component biogenesis#GO:0044085;RNA metabolic process#GO:0016070;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;ribonucleoprotein complex biogenesis#GO:0022613;maturation of 5.8S rRNA#GO:0000460;regulation of gene silencing by regulatory ncRNA#GO:0060966;regulation of cellular component organization#GO:0051128;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 exoribonuclease#PC00099 HUMAN|HGNC=28520|UniProtKB=Q8NHR7 Q8NHR7 TERB2 PTHR35345:SF1 TELOMERE REPEATS-BINDING BOUQUET FORMATION PROTEIN 2 TELOMERE REPEATS-BINDING BOUQUET FORMATION PROTEIN 2 chromosome localization#GO:0050000;homologous chromosome pairing at meiosis#GO:0007129;cellular process#GO:0009987;organelle organization#GO:0006996;meiotic chromosome segregation#GO:0045132;chromosome organization#GO:0051276;meiotic nuclear division#GO:0140013;cellular component organization or biogenesis#GO:0071840;homologous chromosome segregation#GO:0045143;chromosome segregation#GO:0007059;meiotic cell cycle#GO:0051321;chromosome organization involved in meiotic cell cycle#GO:0070192;reproductive process#GO:0022414;cell cycle process#GO:0022402;meiosis I#GO:0007127;meiotic cell cycle process#GO:1903046;cellular component organization#GO:0016043;nuclear chromosome segregation#GO:0098813;cell cycle#GO:0007049;telomere localization#GO:0034397;organelle fission#GO:0048285;localization#GO:0051179;sexual reproduction#GO:0019953;nuclear division#GO:0000280;organelle localization#GO:0051640;meiosis I cell cycle process#GO:0061982;telomere tethering at nuclear periphery#GO:0034398 membrane#GO:0016020;organelle envelope#GO:0031967;nucleus#GO:0005634;organelle inner membrane#GO:0019866;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;intracellular organelle#GO:0043229;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear inner membrane#GO:0005637;nuclear membrane#GO:0031965 HUMAN|HGNC=17857|UniProtKB=Q86WT6 Q86WT6 TRIM69 PTHR24103:SF286 E3 UBIQUITIN-PROTEIN LIGASE TRIM E3 UBIQUITIN-PROTEIN LIGASE TRIM69 ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824 immune response#GO:0006955;defense response to symbiont#GO:0140546;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to other organism#GO:0051707;response to stimulus#GO:0050896;defense response to other organism#GO:0098542;immune system process#GO:0002376;response to external stimulus#GO:0009605;defense response#GO:0006952;innate immune response#GO:0045087 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=16305|UniProtKB=Q8TE58 Q8TE58 ADAMTS15 PTHR13723:SF39 ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 15 metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 metabolic process#GO:0008152;proteolysis#GO:0006508;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;extracellular matrix organization#GO:0030198;protein metabolic process#GO:0019538;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization#GO:0016043 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 metalloprotease#PC00153 HUMAN|HGNC=53643|UniProtKB=A6NCN8 A6NCN8 TEX52 PTHR35156:SF1 TESTIS-EXPRESSED PROTEIN 52 TESTIS-EXPRESSED PROTEIN 52 HUMAN|HGNC=18379|UniProtKB=Q86VW0 Q86VW0 SESTD1 PTHR46607:SF1 SEC14 DOMAIN AND SPECTRIN REPEAT-CONTAINING PROTEIN 1 SEC14 DOMAIN AND SPECTRIN REPEAT-CONTAINING PROTEIN 1 lipid binding#GO:0008289;phosphatidylinositol bisphosphate binding#GO:1902936;ion binding#GO:0043167;phosphatidylinositol-4,5-bisphosphate binding#GO:0005546;binding#GO:0005488;anion binding#GO:0043168;small molecule binding#GO:0036094;phosphatidylinositol-3-phosphate binding#GO:0032266;phosphatidylinositol phosphate binding#GO:1901981;phospholipid binding#GO:0005543 HUMAN|HGNC=21035|UniProtKB=Q8N392 Q8N392 ARHGAP18 PTHR14963:SF6 RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED RHO GTPASE-ACTIVATING PROTEIN 18 enzyme activator activity#GO:0008047;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772 regulation of response to stimulus#GO:0048583;regulation of actin filament-based process#GO:0032970;regulation of anatomical structure size#GO:0090066;regulation of small GTPase mediated signal transduction#GO:0051056;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;regulation of actin filament organization#GO:0110053;regulation of actin cytoskeleton organization#GO:0032956;regulation of actin polymerization or depolymerization#GO:0008064;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of actin filament polymerization#GO:0030833;regulation of signaling#GO:0023051;regulation of actin filament length#GO:0030832;regulation of intracellular signal transduction#GO:1902531;regulation of biological quality#GO:0065008;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of supramolecular fiber organization#GO:1902903;regulation of cellular component size#GO:0032535;cellular component organization#GO:0016043;regulation of protein-containing complex assembly#GO:0043254;regulation of cellular component biogenesis#GO:0044087;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;regulation of protein polymerization#GO:0032271 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 GTPase-activating protein#PC00257;G-protein modulator#PC00022 HUMAN|Ensembl=ENSG00000292226.2|UniProtKB=A0AAG2UXS2 A0AAG2UXS2 LOC124905558 PTHR14199:SF35 NEUROBLASTOMA BREAKPOINT FAMILY MEMBER 6-LIKE PROTEIN NBPF FAMILY MEMBER NBPF1-RELATED HUMAN|HGNC=23586|UniProtKB=B3EWG5 B3EWG5 FAM25C PTHR34994:SF1 PROTEIN FAM25A-RELATED PROTEIN FAM25A-RELATED HUMAN|HGNC=5136|UniProtKB=P35453 P35453 HOXD13 PTHR45804:SF4 SEGMENTATION PROTEIN FUSHI TARAZU-LIKE PROTEIN HOMEOBOX PROTEIN HOX-D13 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=16669|UniProtKB=Q5DX21 Q5DX21 IGSF11 PTHR44699:SF1 IMMUNOGLOBULIN SUPERFAMILY MEMBER 11 IMMUNOGLOBULIN SUPERFAMILY MEMBER 11 cell-cell adhesion#GO:0098609;cell adhesion#GO:0007155;cellular process#GO:0009987 cell-cell junction#GO:0005911;cell junction#GO:0030054;cellular anatomical structure#GO:0110165;anchoring junction#GO:0070161 immunoglobulin#PC00123 HUMAN|HGNC=15901|UniProtKB=Q9Y366 Q9Y366 IFT52 PTHR12969:SF7 NGD5/OSM-6/IFT52 INTRAFLAGELLAR TRANSPORT PROTEIN 52 HOMOLOG cellular component assembly#GO:0022607;cytoskeleton-dependent intracellular transport#GO:0030705;plasma membrane bounded cell projection organization#GO:0120036;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;establishment of localization in cell#GO:0051649;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;transport along microtubule#GO:0010970;establishment of localization#GO:0051234;microtubule-based process#GO:0007017;plasma membrane bounded cell projection assembly#GO:0120031;intracellular transport#GO:0046907;transport#GO:0006810;cell projection organization#GO:0030030;microtubule-based movement#GO:0007018;intraciliary transport#GO:0042073;cilium assembly#GO:0060271;cellular component organization#GO:0016043;localization#GO:0051179;cellular localization#GO:0051641;cilium organization#GO:0044782;organelle assembly#GO:0070925;microtubule-based transport#GO:0099111 microtubule cytoskeleton#GO:0015630;centriole#GO:0005814;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;intraciliary transport particle B#GO:0030992;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;membraneless organelle#GO:0043228;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cilium#GO:0005929;intracellular organelle#GO:0043229;intraciliary transport particle#GO:0030990;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=7754|UniProtKB=Q92859 Q92859 NEO1 PTHR10075:SF124 BASIGIN RELATED NEOGENIN cell adhesion molecule#PC00069 HUMAN|HGNC=40048|UniProtKB=F5H4A9 F5H4A9 C3orf80 PTHR38505:SF1 HYPOTHETICAL PROTEIN LOC100362176 SIMILAR TO HUMAN CHROMOSOME 3 OPEN READING FRAME 80 HUMAN|HGNC=14950|UniProtKB=Q96KQ4 Q96KQ4 PPP1R13B PTHR24131:SF5 APOPTOSIS-STIMULATING OF P53 PROTEIN APOPTOSIS-STIMULATING OF P53 PROTEIN 1 binding#GO:0005488;protein binding#GO:0005515 apoptotic signaling pathway#GO:0097190;cellular process#GO:0009987;signal transduction#GO:0007165;biological regulation#GO:0065007;signal transduction by p53 class mediator#GO:0072331;intracellular signal transduction#GO:0035556;intrinsic apoptotic signaling pathway#GO:0097193;cell communication#GO:0007154;apoptotic process#GO:0006915;cellular response to stimulus#GO:0051716;cell death#GO:0008219;regulation of biological process#GO:0050789;programmed cell death#GO:0012501;signaling#GO:0023052;regulation of cellular process#GO:0050794;intrinsic apoptotic signaling pathway by p53 class mediator#GO:0072332;response to stimulus#GO:0050896 intracellular organelle#GO:0043229;cell junction#GO:0030054;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;membrane-bounded organelle#GO:0043227;adherens junction#GO:0005912;cell-cell junction#GO:0005911;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;perinuclear region of cytoplasm#GO:0048471 protein-binding activity modulator#PC00095 HUMAN|HGNC=14919|UniProtKB=Q9NYV9 Q9NYV9 TAS2R13 PTHR11394:SF28 TASTE RECEPTOR TYPE 2 TASTE RECEPTOR TYPE 2 MEMBER 13 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;taste receptor activity#GO:0008527;molecular transducer activity#GO:0060089;bitter taste receptor activity#GO:0033038 sensory perception#GO:0007600;detection of chemical stimulus involved in sensory perception of taste#GO:0050912;nervous system process#GO:0050877;sensory perception of taste#GO:0050909;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;system process#GO:0003008;detection of chemical stimulus involved in sensory perception of bitter taste#GO:0001580;sensory perception of bitter taste#GO:0050913;detection of chemical stimulus#GO:0009593;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;response to chemical#GO:0042221;response to stimulus#GO:0050896;multicellular organismal process#GO:0032501 membrane#GO:0016020;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=6595|UniProtKB=Q9UBR4 Q9UBR4 LHX3 PTHR24208:SF91 LIM/HOMEOBOX PROTEIN LHX LIM_HOMEOBOX PROTEIN LHX3 transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 neuron differentiation#GO:0030182;developmental process#GO:0032502;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;nervous system development#GO:0007399;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119 HUMAN|HGNC=21751|UniProtKB=Q8IY47 Q8IY47 KBTBD2 PTHR24412:SF192 KELCH PROTEIN KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 2 enzyme-substrate adaptor activity#GO:0140767;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511 transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;ubiquitin ligase complex#GO:0000151;Cul3-RING ubiquitin ligase complex#GO:0031463;cytoplasm#GO:0005737;cullin-RING ubiquitin ligase complex#GO:0031461;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 scaffold/adaptor protein#PC00226 HUMAN|HGNC=15977|UniProtKB=Q9BYE0 Q9BYE0 HES7 PTHR10985:SF84 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED TRANSCRIPTION FACTOR HES-7 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of cell development#GO:0060284;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regionalization#GO:0003002;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cell differentiation#GO:0045595;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of neurogenesis#GO:0050767;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;pattern specification process#GO:0007389;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;anatomical structure development#GO:0048856;regulation of nervous system development#GO:0051960;regulation of DNA-templated transcription#GO:0006355;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of multicellular organismal process#GO:0051239;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;anterior/posterior pattern specification#GO:0009952;multicellular organism development#GO:0007275;regulation of multicellular organismal development#GO:2000026;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=11196|UniProtKB=O60248 O60248 SOX15 PTHR10270:SF45 SOX TRANSCRIPTION FACTOR TRANSCRIPTION FACTOR SOX-15 DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulator activity#GO:0140110;DNA-binding transcription activator activity#GO:0001216;sequence-specific DNA binding#GO:0043565;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228 positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;negative regulation of transcription by RNA polymerase II#GO:0000122;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;regulation of nucleobase-containing compound metabolic process#GO:0019219;brain development#GO:0007420;multicellular organismal process#GO:0032501;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;cell differentiation#GO:0030154;central nervous system development#GO:0007417;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;multicellular organism development#GO:0007275;animal organ development#GO:0048513;positive regulation of transcription by RNA polymerase II#GO:0045944;neuron differentiation#GO:0030182;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;positive regulation of macromolecule metabolic process#GO:0010604;nervous system development#GO:0007399;head development#GO:0060322;negative regulation of macromolecule biosynthetic process#GO:0010558;positive regulation of biological process#GO:0048518;cellular process#GO:0009987 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 gene-specific transcriptional regulator#PC00264;HMG box transcription factor#PC00024;DNA-binding transcription factor#PC00218 HUMAN|HGNC=26993|UniProtKB=Q19AV6 Q19AV6 ZSWIM7 PTHR28498:SF1 ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 7 ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 7 macromolecule metabolic process#GO:0043170;double-strand break repair#GO:0006302;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;DNA damage response#GO:0006974;DNA recombination#GO:0006310;nucleobase-containing compound metabolic process#GO:0006139;response to stress#GO:0006950;cellular process#GO:0009987;recombinational repair#GO:0000725;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular response to stimulus#GO:0051716;double-strand break repair via homologous recombination#GO:0000724 protein-containing complex#GO:0032991 HUMAN|HGNC=26722|UniProtKB=Q8N9M5 Q8N9M5 TMEM102 PTHR10656:SF48 CELL FATE DETERMINING PROTEIN MAB21-RELATED TRANSMEMBRANE PROTEIN 102 cellular anatomical structure#GO:0110165;cell surface#GO:0009986 transferase#PC00220;nucleotidyltransferase#PC00174 FGF signaling pathway#P00021>FGF#P00623 HUMAN|HGNC=25160|UniProtKB=Q96EK9 Q96EK9 KTI12 PTHR12435:SF2 FAMILY NOT NAMED PROTEIN KTI12 HOMOLOG tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;RNA biosynthetic process#GO:0032774;tRNA modification#GO:0006400;tRNA wobble uridine modification#GO:0002098;tRNA wobble base modification#GO:0002097;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 HUMAN|HGNC=14966|UniProtKB=Q92626 Q92626 PXDN PTHR11475:SF75 OXIDASE/PEROXIDASE PEROXIDASIN HOMOLOG oxidoreductase activity, acting on peroxide as acceptor#GO:0016684;oxidoreductase activity#GO:0016491;antioxidant activity#GO:0016209;peroxidase activity#GO:0004601;catalytic activity#GO:0003824 extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;cellular component assembly#GO:0022607;extracellular matrix assembly#GO:0085029 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 peroxidase#PC00180;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=2209|UniProtKB=P20908 P20908 COL5A1 PTHR24023:SF387 COLLAGEN ALPHA COLLAGEN ALPHA-1(V) CHAIN structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;external encapsulating structure organization#GO:0045229;extracellular structure organization#GO:0043062;cellular component organization#GO:0016043;cellular process#GO:0009987;cell adhesion#GO:0007155 extracellular region#GO:0005576;extracellular protein-containing complex#GO:0140392;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;interstitial matrix#GO:0005614;supramolecular complex#GO:0099080;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 Integrin signalling pathway#P00034>Collagen#P00922 HUMAN|HGNC=27780|UniProtKB=E2RYF7 E2RYF7 HCG22 PTHR22467:SF4 EZH INHIBITORY PROTEIN-RELATED PROTEIN PBMUCL2 HUMAN|HGNC=24076|UniProtKB=Q6AI08 Q6AI08 HEATR6 PTHR13366:SF0 MALARIA ANTIGEN-RELATED HEAT REPEAT-CONTAINING PROTEIN 6 HUMAN|HGNC=11377|UniProtKB=P49888 P49888 SULT1E1 PTHR11783:SF53 SULFOTRANSFERASE SULT SULFOTRANSFERASE 1E1 sulfotransferase activity#GO:0008146;transferase activity, transferring sulphur-containing groups#GO:0016782;catalytic activity#GO:0003824;transferase activity#GO:0016740 sulfur compound metabolic process#GO:0006790;metabolic process#GO:0008152;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;transferase#PC00220 HUMAN|HGNC=27293|UniProtKB=C9JUS6 C9JUS6 ADM5 PTHR23414:SF6 ADRENOMEDULLIN, ADM ADRENOMEDULLIN-5-LIKE PROTEIN-RELATED molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;hormone activity#GO:0005179;signaling receptor activator activity#GO:0030546;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018 regulation of system process#GO:0044057;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;system process#GO:0003008;regulation of blood pressure#GO:0008217;regulation of systemic arterial blood pressure#GO:0003073;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;renal system process#GO:0003014;blood circulation#GO:0008015;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;regulation of multicellular organismal process#GO:0051239;G protein-coupled receptor signaling pathway#GO:0007186;circulatory system process#GO:0003013;cell communication#GO:0007154;regulation of biological quality#GO:0065008;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;positive regulation of multicellular organismal process#GO:0051240;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of body fluid levels#GO:0050878;signaling#GO:0023052;regulation of heart contraction#GO:0008016 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207;peptide hormone#PC00179 HUMAN|HGNC=27038|UniProtKB=Q6JVE9 Q6JVE9 LCN8 PTHR11430:SF1 LIPOCALIN EPIDIDYMAL-SPECIFIC LIPOCALIN-8 transfer/carrier protein#PC00219 HUMAN|HGNC=29353|UniProtKB=Q6PI77 Q6PI77 GPRASP3 PTHR46414:SF2 PROTEIN BHLHB9-RELATED G PROTEIN-COUPLED RECEPTOR ASSOCIATED SORTING PROTEIN 3 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=23199|UniProtKB=Q8N456 Q8N456 LRRC18 PTHR45752:SF146 LEUCINE-RICH REPEAT-CONTAINING LEUCINE-RICH REPEAT-CONTAINING PROTEIN 18 scaffold/adaptor protein#PC00226 HUMAN|HGNC=20438|UniProtKB=A8MTL3 A8MTL3 RNF212B PTHR22663:SF29 RING FINGER PROTEIN NARYA-RELATED E3 UBIQUITIN-PROTEIN LIGASE RNF212B acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;SUMO transferase activity#GO:0019789;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 organelle fission#GO:0048285;nuclear division#GO:0000280;meiosis I cell cycle process#GO:0061982;sexual reproduction#GO:0019953;reproductive process#GO:0022414;cellular component organization#GO:0016043;meiotic cell cycle process#GO:1903046;nuclear chromosome segregation#GO:0098813;meiosis I#GO:0007127;cell cycle#GO:0007049;cell cycle process#GO:0022402;meiotic nuclear division#GO:0140013;homologous chromosome segregation#GO:0045143;cellular component organization or biogenesis#GO:0071840;chromosome organization#GO:0051276;meiotic chromosome segregation#GO:0045132;chromosome organization involved in meiotic cell cycle#GO:0070192;meiotic cell cycle#GO:0051321;chromosome segregation#GO:0007059;homologous chromosome pairing at meiosis#GO:0007129;organelle organization#GO:0006996;cellular process#GO:0009987 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;chromosome#GO:0005694;organelle lumen#GO:0043233;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;condensed chromosome#GO:0000793;membraneless organelle#GO:0043228;condensed nuclear chromosome#GO:0000794;synaptonemal complex#GO:0000795;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;synaptonemal structure#GO:0099086;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232 HUMAN|HGNC=8351|UniProtKB=Q8NGL0 Q8NGL0 OR5L2 PTHR48018:SF16 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5L2 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;signaling#GO:0023052;response to stimulus#GO:0050896;sensory perception of smell#GO:0007608;regulation of cellular process#GO:0050794;sensory perception#GO:0007600;nervous system process#GO:0050877;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=2090|UniProtKB=P09496 P09496 CLTA PTHR10639:SF1 CLATHRIN LIGHT CHAIN CLATHRIN LIGHT CHAIN A protein binding#GO:0005515;binding#GO:0005488;clathrin binding#GO:0030276 transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;import into cell#GO:0098657;receptor-mediated endocytosis#GO:0006898;clathrin-dependent endocytosis#GO:0072583;cellular process#GO:0009987;endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192 membrane coat#GO:0030117;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane protein complex#GO:0098796;synaptic vesicle#GO:0008021;vesicle#GO:0031982;synaptic vesicle membrane#GO:0030672;intracellular membrane-bounded organelle#GO:0043231;clathrin-coated vesicle#GO:0030136;organelle membrane#GO:0031090;membrane#GO:0016020;vesicle membrane#GO:0012506;cell periphery#GO:0071944;transport vesicle membrane#GO:0030658;endomembrane system#GO:0012505;transport vesicle#GO:0030133;plasma membrane#GO:0005886;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;coated membrane#GO:0048475;coated vesicle#GO:0030135;intracellular vesicle#GO:0097708;synapse#GO:0045202;cellular anatomical structure#GO:0110165;clathrin coat#GO:0030118;organelle#GO:0043226;coated vesicle membrane#GO:0030662;clathrin vesicle coat#GO:0030125;clathrin-coated vesicle membrane#GO:0030665;cell junction#GO:0030054;bounding membrane of organelle#GO:0098588;secretory vesicle#GO:0099503;presynapse#GO:0098793;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;vesicle coat#GO:0030120 membrane traffic protein#PC00150;vesicle coat protein#PC00235 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Clathrin#P00722;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Clathrin#P00738;Huntington disease#P00029>Clathrin#P00798 HUMAN|HGNC=1169|UniProtKB=Q9NQ32 Q9NQ32 C11orf16 PTHR14343:SF3 VWFA DOMAIN-CONTAINING PROTEIN SIMILAR TO HUMAN CHROMOSOME 11 OPEN READING FRAME 16 HUMAN|HGNC=4056|UniProtKB=P35575 P35575 G6PC1 PTHR12591:SF3 GLUCOSE-6-PHOSPHATASE GLUCOSE-6-PHOSPHATASE CATALYTIC SUBUNIT 1 phosphatase activity#GO:0016791;sugar-phosphatase activity#GO:0050308;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578 hexose metabolic process#GO:0019318;primary metabolic process#GO:0044238;cellular process#GO:0009987;hexose biosynthetic process#GO:0019319;gluconeogenesis#GO:0006094;small molecule metabolic process#GO:0044281;carbohydrate biosynthetic process#GO:0016051;biosynthetic process#GO:0009058;carbohydrate metabolic process#GO:0005975;monosaccharide biosynthetic process#GO:0046364;monosaccharide metabolic process#GO:0005996;metabolic process#GO:0008152;small molecule biosynthetic process#GO:0044283;glucose metabolic process#GO:0006006 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020 hydrolase#PC00121;phosphatase#PC00181 Phenylethylamine degradation#P02766>Phenylethylamine oxidase#P03103 HUMAN|HGNC=53085|UniProtKB=A0A1W2PRN6 A0A1W2PRN6 LINC02218 PTHR13218:SF17 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11-RELATED LONG INTERGENIC NON-PROTEIN CODING RNA 2218 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;transcription initiation at RNA polymerase II promoter#GO:0006367;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;protein-DNA complex assembly#GO:0065004;gene expression#GO:0010467;cellular component assembly#GO:0022607;transcription by RNA polymerase II#GO:0006366;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;protein-DNA complex organization#GO:0071824;macromolecule metabolic process#GO:0043170;protein-containing complex assembly#GO:0065003;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;DNA-templated transcription#GO:0006351;RNA polymerase II preinitiation complex assembly#GO:0051123;RNA biosynthetic process#GO:0032774;DNA-templated transcription initiation#GO:0006352;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070 transcription regulator complex#GO:0005667;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234;transcription factor TFIID complex#GO:0005669;protein-containing complex#GO:0032991;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;membrane-enclosed lumen#GO:0031974;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;RNA polymerase II, holoenzyme#GO:0016591;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233 general transcription factor#PC00259;RNA metabolism protein#PC00031 HUMAN|HGNC=13164|UniProtKB=P62633 P62633 CNBP PTHR23002:SF67 ZINC FINGER CCHC DOMAIN CONTAINING PROTEIN CCHC-TYPE ZINC FINGER NUCLEIC ACID BINDING PROTEIN mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488;single-stranded RNA binding#GO:0003727;RNA binding#GO:0003723 regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of protein metabolic process#GO:0051247;positive regulation of translation#GO:0045727;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of protein metabolic process#GO:0051246;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;positive regulation of macromolecule metabolic process#GO:0010604;post-transcriptional regulation of gene expression#GO:0010608;regulation of gene expression#GO:0010468;positive regulation of gene expression#GO:0010628;regulation of biosynthetic process#GO:0009889 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HUMAN|HGNC=25076|UniProtKB=Q9H094 Q9H094 NBPF3 PTHR14199:SF45 NEUROBLASTOMA BREAKPOINT FAMILY MEMBER 6-LIKE PROTEIN NBPF FAMILY MEMBER NBPF3 HUMAN|HGNC=7135|UniProtKB=P51825 P51825 AFF1 PTHR10528:SF6 AF4/FMR2 FAMILY MEMBER AF4_FMR2 FAMILY MEMBER 1 transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;RNA metabolic process#GO:0016070;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;nucleic acid biosynthetic process#GO:0141187;nervous system process#GO:0050877;regulation of nucleobase-containing compound metabolic process#GO:0019219;gene expression#GO:0010467;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;biosynthetic process#GO:0009058;regulation of RNA biosynthetic process#GO:2001141;nucleobase-containing compound metabolic process#GO:0006139;regulation of primary metabolic process#GO:0080090;DNA-templated transcription elongation#GO:0006354;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;system process#GO:0003008;regulation of gene expression#GO:0010468;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;transcription elongation factor complex#GO:0008023 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=1112|UniProtKB=Q15003 Q15003 NCAPH PTHR13108:SF9 CONDENSIN COMPLEX SUBUNIT 2 CONDENSIN COMPLEX SUBUNIT 2 binding#GO:0005488;chromatin binding#GO:0003682 chromosome condensation#GO:0030261;mitotic chromosome condensation#GO:0007076;organelle fission#GO:0048285;nuclear division#GO:0000280;mitotic cell cycle#GO:0000278;mitotic nuclear division#GO:0140014;cell cycle process#GO:0022402;sister chromatid segregation#GO:0000819;nuclear chromosome segregation#GO:0098813;cellular component organization#GO:0016043;cell cycle#GO:0007049;chromosome organization#GO:0051276;mitotic cell cycle process#GO:1903047;cellular component organization or biogenesis#GO:0071840;chromosome segregation#GO:0007059;cellular process#GO:0009987;organelle organization#GO:0006996;mitotic sister chromatid segregation#GO:0000070 intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;chromosome#GO:0005694;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;condensin complex#GO:0000796 HUMAN|HGNC=25918|UniProtKB=Q969W3 Q969W3 VCF1 PTHR34763:SF1 PROTEIN FAM104A PROTEIN VCF1 HUMAN|HGNC=15799|UniProtKB=Q9NQG1 Q9NQG1 MANBAL PTHR14409:SF2 MANNOSIDASE, BETA A, LYSOSOMAL-LIKE, MANBAL PROTEIN PROTEIN MANBAL HUMAN|HGNC=6998|UniProtKB=O15553 O15553 MEFV PTHR24103:SF606 E3 UBIQUITIN-PROTEIN LIGASE TRIM PYRIN acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 response to stress#GO:0006950;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;response to biotic stimulus#GO:0009607;immune response#GO:0006955;defense response to symbiont#GO:0140546;defense response to other organism#GO:0098542;response to other organism#GO:0051707;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;innate immune response#GO:0045087;regulation of gene expression#GO:0010468;defense response#GO:0006952;response to external stimulus#GO:0009605;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;immune system process#GO:0002376 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=8066|UniProtKB=P37198 P37198 NUP62 PTHR12084:SF0 NUCLEAR PORE GLYCOPROTEIN P62-RELATED NUCLEAR PORE GLYCOPROTEIN P62 structural constituent of nuclear pore#GO:0017056;structural molecule activity#GO:0005198;lipid binding#GO:0008289;phospholipid binding#GO:0005543;binding#GO:0005488 protein import into nucleus#GO:0006606;protein transport#GO:0015031;nuclear export#GO:0051168;nuclear transport#GO:0051169;cellular localization#GO:0051641;nucleic acid transport#GO:0050657;localization#GO:0051179;nucleocytoplasmic transport#GO:0006913;establishment of RNA localization#GO:0051236;protein localization to organelle#GO:0033365;RNA localization#GO:0006403;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;nitrogen compound transport#GO:0071705;protein localization to nucleus#GO:0034504;macromolecule localization#GO:0033036;import into nucleus#GO:0051170 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;nuclear pore#GO:0005643;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;organelle envelope#GO:0031967;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 transporter#PC00227 HUMAN|HGNC=33237|UniProtKB=Q4G0W2 Q4G0W2 DUSP28 PTHR45961:SF7 IP21249P DUAL SPECIFICITY PHOSPHATASE 28 phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;hydrolase activity#GO:0016787;protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721 Oxidative stress response#P00046>MKP5#P01131 HUMAN|HGNC=719|UniProtKB=P51690 P51690 ARSL PTHR42693:SF48 ARYLSULFATASE FAMILY MEMBER ARYLSULFATASE L catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787 hydrolase#PC00121 HUMAN|HGNC=4699|UniProtKB=P46976 P46976 GYG1 PTHR11183:SF164 GLYCOGENIN SUBFAMILY MEMBER GLYCOGENIN-1 glucosyltransferase activity#GO:0046527;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;hexosyltransferase activity#GO:0016758;UDP-glucosyltransferase activity#GO:0035251;transferase activity#GO:0016740;catalytic activity#GO:0003824 polysaccharide biosynthetic process#GO:0000271;energy reserve metabolic process#GO:0006112;glucan biosynthetic process#GO:0009250;glucan metabolic process#GO:0044042;primary metabolic process#GO:0044238;glycogen metabolic process#GO:0005977;carbohydrate metabolic process#GO:0005975;polysaccharide metabolic process#GO:0005976;glycogen biosynthetic process#GO:0005978;generation of precursor metabolites and energy#GO:0006091;metabolic process#GO:0008152;energy derivation by oxidation of organic compounds#GO:0015980;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;carbohydrate biosynthetic process#GO:0016051;biosynthetic process#GO:0009058 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 glycosyltransferase#PC00111;transferase#PC00220 HUMAN|HGNC=51514|UniProtKB=P0DV79 P0DV79 SPDYE18 PTHR31156:SF15 WBSCR19-LIKE PROTEIN SPEEDY PROTEIN E10-RELATED HUMAN|HGNC=25655|UniProtKB=Q9NUJ3 Q9NUJ3 TCP11L1 PTHR12832:SF15 TESTIS-SPECIFIC PROTEIN PBS13 T-COMPLEX 11 T-COMPLEX PROTEIN 11-LIKE PROTEIN 1 biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154 microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=28433|UniProtKB=Q6ZMD2 Q6ZMD2 SPNS3 PTHR23505:SF3 SPINSTER PROTEIN SPINSTER HOMOLOG 3 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 cellular anatomical structure#GO:0110165;membrane#GO:0016020 transporter#PC00227 HUMAN|HGNC=29635|UniProtKB=A6BM72 A6BM72 MEGF11 PTHR24035:SF127 MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN 11 extracellular matrix structural constituent#GO:0005201;structural molecule activity#GO:0005198 membrane organization#GO:0061024;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;phagocytosis, engulfment#GO:0006911;apoptotic cell clearance#GO:0043277;import into cell#GO:0098657;establishment of localization#GO:0051234;phagocytosis#GO:0006909;substrate adhesion-dependent cell spreading#GO:0034446;membrane invagination#GO:0010324;transport#GO:0006810;endocytosis#GO:0006897;cellular component organization#GO:0016043;cell-substrate adhesion#GO:0031589;localization#GO:0051179;cell adhesion#GO:0007155 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576;basement membrane#GO:0005604 extracellular matrix protein#PC00102 HUMAN|HGNC=28979|UniProtKB=Q14687 Q14687 GSE1 PTHR17608:SF4 GENETIC SUPPRESSOR ELEMENT 1 GENETIC SUPPRESSOR ELEMENT 1 HUMAN|HGNC=13561|UniProtKB=Q5T1R4 Q5T1R4 HIVEP3 PTHR45944:SF5 SCHNURRI, ISOFORM F TRANSCRIPTION FACTOR HIVEP3 binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=16527|UniProtKB=Q8TDI7 Q8TDI7 TMC2 PTHR23302:SF17 TRANSMEMBRANE CHANNEL-RELATED TRANSMEMBRANE CHANNEL-LIKE PROTEIN 2 channel activity#GO:0015267;voltage-gated calcium channel activity#GO:0005245;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;voltage-gated channel activity#GO:0022832;transporter activity#GO:0005215;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216 sensory perception of sound#GO:0007605;response to stimulus#GO:0050896;multicellular organismal process#GO:0032501;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;response to abiotic stimulus#GO:0009628;response to mechanical stimulus#GO:0009612;response to external stimulus#GO:0009605;system process#GO:0003008;detection of mechanical stimulus#GO:0050982;sensory perception#GO:0007600;sensory perception of mechanical stimulus#GO:0050954;nervous system process#GO:0050877 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 ion channel#PC00133 HUMAN|HGNC=33705|UniProtKB=Q6UWW9 Q6UWW9 TMEM207 PTHR36467:SF1 TRANSMEMBRANE PROTEIN 207 TRANSMEMBRANE PROTEIN 207 HUMAN|HGNC=3599|UniProtKB=P22087 P22087 FBL PTHR10335:SF4 RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN RRNA 2'-O-METHYLTRANSFERASE FIBRILLARIN transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;RNA methyltransferase activity#GO:0008173;catalytic activity, acting on RNA#GO:0140098;histone methyltransferase activity#GO:0042054;methyltransferase activity#GO:0008168;binding#GO:0005488;histone modifying activity#GO:0140993;protein methyltransferase activity#GO:0008276;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;rRNA methyltransferase activity#GO:0008649;catalytic activity, acting on a protein#GO:0140096;N-methyltransferase activity#GO:0008170;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;nucleic acid binding#GO:0003676;catalytic activity, acting on a rRNA#GO:0140102;RNA binding#GO:0003723 rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;rRNA methylation#GO:0031167;RNA 3'-end processing#GO:0031123;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;RNA modification#GO:0009451;macromolecule methylation#GO:0043414;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;RNA methylation#GO:0001510;RNA metabolic process#GO:0016070;methylation#GO:0032259;macromolecule modification#GO:0043412;rRNA modification#GO:0000154;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774 sno(s)RNA-containing ribonucleoprotein complex#GO:0005732;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;preribosome#GO:0030684;intracellular organelle#GO:0043229;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;small-subunit processome#GO:0032040;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;nuclear body#GO:0016604;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 RNA processing factor#PC00147 HUMAN|HGNC=10980|UniProtKB=Q9UBX3 Q9UBX3 SLC25A10 PTHR45618:SF13 MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED MITOCHONDRIAL DICARBOXYLATE CARRIER transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;C4-dicarboxylate transmembrane transporter activity#GO:0015556;succinate transmembrane transporter activity#GO:0015141;dicarboxylic acid transmembrane transporter activity#GO:0005310 inorganic anion transport#GO:0015698;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;C4-dicarboxylate transport#GO:0015740;organic acid transport#GO:0015849;transport#GO:0006810;carboxylic acid transport#GO:0046942;phosphate ion transport#GO:0006817;carboxylic acid transmembrane transport#GO:1905039;dicarboxylic acid transport#GO:0006835;succinate transport#GO:0015744;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;membrane#GO:0016020;organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743 secondary carrier transporter#PC00258;transporter#PC00227 HUMAN|HGNC=490|UniProtKB=Q9UKU9 Q9UKU9 ANGPTL2 PTHR19143:SF24 FIBRINOGEN/TENASCIN/ANGIOPOEITIN ANGIOPOIETIN-RELATED PROTEIN 2 protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012 intercellular signal molecule#PC00207 HUMAN|HGNC=29387|UniProtKB=Q6NSI8 Q6NSI8 SANBR PTHR20946:SF0 SANT AND BTB DOMAIN REGULATOR OF CLASS SWITCH RECOMBINATION SANT AND BTB DOMAIN REGULATOR OF CLASS SWITCH RECOMBINATION DNA metabolic process#GO:0006259;metabolic process#GO:0008152;leukocyte activation involved in immune response#GO:0002366;immune effector process#GO:0002252;DNA recombination#GO:0006310;multicellular organism development#GO:0007275;B cell activation#GO:0042113;somatic recombination of immunoglobulin gene segments#GO:0016447;cellular process#GO:0009987;lymphocyte activation involved in immune response#GO:0002285;gene expression#GO:0010467;lymphocyte activation#GO:0046649;B cell activation involved in immune response#GO:0002312;animal gross anatomical part developmental process#GO:0160108;immune system process#GO:0002376;somatic diversification of immune receptors via germline recombination within a single locus#GO:0002562;immune system development#GO:0002520;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449;cell activation involved in immune response#GO:0002263;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;production of molecular mediator of immune response#GO:0002440;response to stimulus#GO:0050896;developmental process#GO:0032502;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;immune response#GO:0006955;multicellular organismal process#GO:0032501;adaptive immune response#GO:0002250;somatic cell DNA recombination#GO:0016444;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;cell activation#GO:0001775;anatomical structure development#GO:0048856;system development#GO:0048731;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;leukocyte activation#GO:0045321;somatic diversification of immune receptors#GO:0002200 HUMAN|HGNC=18165|UniProtKB=Q9Y6J8 Q9Y6J8 STYXL1 PTHR46659:SF1 SERINE/THREONINE/TYROSINE-INTERACTING-LIKE PROTEIN 1 SERINE_THREONINE_TYROSINE-INTERACTING-LIKE PROTEIN 1 enzyme inhibitor activity#GO:0004857;protein phosphatase binding#GO:0019903;molecular function regulator activity#GO:0098772;phosphatase inhibitor activity#GO:0019212;phosphatase regulator activity#GO:0019208;enzyme binding#GO:0019899;phosphatase binding#GO:0019902;binding#GO:0005488;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;protein binding#GO:0005515 positive regulation of apoptotic process#GO:0043065;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of apoptotic process#GO:0042981;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of response to stimulus#GO:0048584;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of organelle assembly#GO:1902115;positive regulation of signaling#GO:0023056;regulation of intracellular signal transduction#GO:1902531;regulation of apoptotic signaling pathway#GO:2001233;regulation of signaling#GO:0023051;positive regulation of programmed cell death#GO:0043068;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of cellular component biogenesis#GO:0044087;regulation of cell communication#GO:0010646;positive regulation of apoptotic signaling pathway#GO:2001235;negative regulation of organelle organization#GO:0010639;negative regulation of cellular component organization#GO:0051129;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;positive regulation of signal transduction#GO:0009967;regulation of intrinsic apoptotic signaling pathway#GO:2001242;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 Oxidative stress response#P00046>MKP5#P01131 HUMAN|HGNC=6492|UniProtKB=P11047 P11047 LAMC1 PTHR10574:SF270 NETRIN/LAMININ-RELATED LAMININ SUBUNIT GAMMA-1 cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;neuron projection guidance#GO:0097485;cell projection morphogenesis#GO:0048858;neurogenesis#GO:0022008;neuron differentiation#GO:0030182;developmental process#GO:0032502;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;tissue development#GO:0009888;plasma membrane bounded cell projection organization#GO:0120036;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;neuron projection development#GO:0031175;axon development#GO:0061564;axon guidance#GO:0007411;cellular process#GO:0009987;anatomical structure development#GO:0048856;system development#GO:0048731;neuron development#GO:0048666;axonogenesis#GO:0007409;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell morphogenesis#GO:0000902;cell development#GO:0048468;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576;basement membrane#GO:0005604;cellular anatomical structure#GO:0110165 extracellular matrix protein#PC00102 Integrin signalling pathway#P00034>Laminin#P00947 HUMAN|HGNC=20525|UniProtKB=P60410 P60410 KRTAP10-8 PTHR23262:SF50 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 10-8 structural protein#PC00211 HUMAN|HGNC=8603|UniProtKB=O43252 O43252 PAPSS1 PTHR11055:SF17 BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE 1 phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 purine-containing compound biosynthetic process#GO:0072522;oxoacid metabolic process#GO:0043436;purine nucleotide biosynthetic process#GO:0006164;ribonucleotide metabolic process#GO:0009259;nucleotide biosynthetic process#GO:0009165;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;organophosphate biosynthetic process#GO:0090407;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing compound biosynthetic process#GO:0034654;nucleobase-containing small molecule metabolic process#GO:0055086;nucleoside phosphate biosynthetic process#GO:1901293;carbohydrate derivative biosynthetic process#GO:1901137;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;ribose phosphate biosynthetic process#GO:0046390;sulfur compound metabolic process#GO:0006790;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139 Sulfate assimilation#P02778>Sulfate adenylyltransferase#P03167 HUMAN|HGNC=6954|UniProtKB=Q8NEM0 Q8NEM0 MCPH1 PTHR14625:SF3 MICROCEPHALIN MICROCEPHALIN mitotic cell cycle#GO:0000278;cellular process#GO:0009987;cell cycle#GO:0007049 damaged DNA-binding protein#PC00086;DNA metabolism protein#PC00009 HUMAN|HGNC=13922|UniProtKB=Q5SRN2 Q5SRN2 TSBP1 PTHR14368:SF7 TESTIS-EXPRESSED BASIC PROTEIN 1 TESTIS-EXPRESSED BASIC PROTEIN 1 HUMAN|HGNC=17485|UniProtKB=Q969Q6 Q969Q6 PPP2R3C PTHR12085:SF7 SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B'' SUBUNIT GAMMA SERINE_THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B'' SUBUNIT GAMMA regulation of lymphocyte activation#GO:0051249;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of cell activation#GO:0050865;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;regulation of leukocyte activation#GO:0002694;microtubule cytoskeleton organization#GO:0000226;cortical cytoskeleton organization#GO:0030865;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;cellular process#GO:0009987;regulation of B cell activation#GO:0050864;organelle organization#GO:0006996;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840 intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microtubule cytoskeleton#GO:0015630;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;centrosome#GO:0005813;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856 protein phosphatase#PC00195 HUMAN|HGNC=262|UniProtKB=P30542 P30542 ADORA1 PTHR24246:SF1 OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR ADENOSINE RECEPTOR A1 G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;neuron projection#GO:0043005;membrane#GO:0016020;cell junction#GO:0030054;dendritic tree#GO:0097447;dendrite#GO:0030425 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GoPCR#P00725 HUMAN|HGNC=23157|UniProtKB=Q9Y672 Q9Y672 ALG6 PTHR12413:SF1 DOLICHYL GLYCOSYLTRANSFERASE DOLICHYL PYROPHOSPHATE MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE glucosyltransferase activity#GO:0046527;glycosyltransferase activity#GO:0016757;hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740 biosynthetic process#GO:0009058;glycoprotein biosynthetic process#GO:0009101;protein N-linked glycosylation#GO:0006487;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100 membrane#GO:0016020;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;glycosyltransferase#PC00111 HUMAN|HGNC=4379|UniProtKB=P29992 P29992 GNA11 PTHR10218:SF328 GTP-BINDING PROTEIN ALPHA SUBUNIT GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-11 ribonucleoside triphosphate phosphatase activity#GO:0017111;molecular function regulator activity#GO:0098772;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924 adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;regulation of membrane potential#GO:0042391;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;G protein-coupled dopamine receptor signaling pathway#GO:0007212;biological regulation#GO:0065007;cellular response to nitrogen compound#GO:1901699;response to chemical#GO:0042221;phospholipase C-activating G protein-coupled receptor signaling pathway#GO:0007200;response to oxygen-containing compound#GO:1901700;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;regulation of biological quality#GO:0065008;response to nitrogen compound#GO:1901698;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;action potential#GO:0001508;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 catalytic complex#GO:1902494;extrinsic component of cytoplasmic side of plasma membrane#GO:0031234;side of membrane#GO:0098552;intracellular anatomical structure#GO:0005622;membrane protein complex#GO:0098796;cytoplasmic side of plasma membrane#GO:0009898;plasma membrane protein complex#GO:0098797;cellular anatomical structure#GO:0110165;cytoplasmic side of membrane#GO:0098562;extrinsic component of membrane#GO:0019898;extrinsic component of plasma membrane#GO:0019897;membrane#GO:0016020;cell periphery#GO:0071944;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;cytoplasm#GO:0005737 heterotrimeric G-protein#PC00117;G-protein#PC00020 Wnt signaling pathway#P00057>Galpha#P01451;PI3 kinase pathway#P00048>Galpha#P01199;Metabotropic glutamate receptor group I pathway#P00041>G-Protein#P01057;Gonadotropin-releasing hormone receptor pathway#P06664>gnaq/11#P06841;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Galphai/q#P00873;Thyrotropin-releasing hormone receptor signaling pathway#P04394>G-Protein#P04584;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Galphaq#P00826;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Gqalpha#P00732;5HT2 type receptor mediated signaling pathway#P04374>G-protein#P04416;Cortocotropin releasing factor receptor signaling pathway#P04380>G-Protein#P04458;Histamine H1 receptor mediated signaling pathway#P04385>G-Protein#P04488;Oxytocin receptor mediated signaling pathway#P04391>G-Protein#P04534;Endothelin signaling pathway#P00019>Gq#P00586;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>G-Protein#P01073;Alpha adrenergic receptor signaling pathway#P00002>G-Protein#P00077 HUMAN|HGNC=1233|UniProtKB=P81408 P81408 ENTREP3 PTHR17615:SF7 PROTEIN FAM189A PROTEIN ENTREP3 HUMAN|HGNC=17641|UniProtKB=Q9H816 Q9H816 DCLRE1B PTHR23240:SF26 DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED 5' EXONUCLEASE APOLLO catalytic activity, acting on DNA#GO:0140097;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;DNA exonuclease activity#GO:0004529;damaged DNA binding#GO:0003684;hydrolase activity, acting on ester bonds#GO:0016788;DNA nuclease activity#GO:0004536;hydrolase activity#GO:0016787;DNA binding#GO:0003677;DNA exonuclease activity, producing 5'-phosphomonoesters#GO:0016895;nuclease activity#GO:0004518;5'-3' exonuclease activity#GO:0008409;exonuclease activity#GO:0004527;binding#GO:0005488;nucleic acid binding#GO:0003676 cellular response to stimulus#GO:0051716;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;telomere organization#GO:0032200;cellular process#GO:0009987;organelle organization#GO:0006996;response to stress#GO:0006950;interstrand cross-link repair#GO:0036297;nucleobase-containing compound metabolic process#GO:0006139;DNA damage response#GO:0006974;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;chromosome organization#GO:0051276;double-strand break repair#GO:0006302;telomere maintenance#GO:0000723;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;double-strand break repair via nonhomologous end joining#GO:0006303 chromosome#GO:0005694;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;chromosome, telomeric region#GO:0000781;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622 DNA metabolism protein#PC00009 HUMAN|HGNC=24712|UniProtKB=Q5VWP2 Q5VWP2 TENT5C PTHR12974:SF34 PRION-LIKE- Q/N-RICH -DOMAIN-BEARING PROTEIN PROTEIN 44 TERMINAL NUCLEOTIDYLTRANSFERASE 5C transferase activity, transferring phosphorus-containing groups#GO:0016772;adenylyltransferase activity#GO:0070566;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779 regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA stability#GO:0043487;negative regulation of catabolic process#GO:0009895;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of RNA catabolic process#GO:1902369;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;positive regulation of gene expression#GO:0010628;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of mRNA stability#GO:0043488;regulation of biological quality#GO:0065008;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;RNA stabilization#GO:0043489;positive regulation of biological process#GO:0048518;mRNA stabilization#GO:0048255;positive regulation of macromolecule metabolic process#GO:0010604;negative regulation of RNA metabolic process#GO:0051253;regulation of mRNA metabolic process#GO:1903311 HUMAN|HGNC=13452|UniProtKB=Q96R06 Q96R06 SPAG5 PTHR15347:SF1 SPERM-ASSOCIATED ANTIGEN 5 SPERM-ASSOCIATED ANTIGEN 5 HUMAN|HGNC=28197|UniProtKB=Q9BR84 Q9BR84 ZNF559 PTHR24381:SF77 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 559 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=30166|UniProtKB=Q502X0 Q502X0 MORN2 PTHR46917:SF1 MORN REPEAT-CONTAINING PROTEIN 2 MORN REPEAT-CONTAINING PROTEIN 2 HUMAN|HGNC=29319|UniProtKB=A0MZ66 A0MZ66 SHTN1 PTHR46606:SF3 SHOOTIN-1 SHOOTIN-1 multicellular organismal process#GO:0032501;regulation of locomotion#GO:0040012;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;positive regulation of cell migration#GO:0030335;positive regulation of cellular process#GO:0048522;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;positive regulation of locomotion#GO:0040017;regulation of neuron migration#GO:2001222;neuron projection morphogenesis#GO:0048812;regulation of cell migration#GO:0030334;developmental process#GO:0032502;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;regulation of cell motility#GO:2000145;system development#GO:0048731;nervous system development#GO:0007399;neuron projection development#GO:0031175;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cell projection morphogenesis#GO:0048858;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell development#GO:0048468;cellular component organization#GO:0016043;positive regulation of cell motility#GO:2000147;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699 site of polarized growth#GO:0030427;intracellular anatomical structure#GO:0005622;axon#GO:0030424;growth cone#GO:0030426;axonal growth cone#GO:0044295;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;cytoplasm#GO:0005737;distal axon#GO:0150034;plasma membrane bounded cell projection#GO:0120025;cell leading edge#GO:0031252;neuron projection#GO:0043005 HUMAN|HGNC=24235|UniProtKB=Q8TD46 Q8TD46 CD200R1 PTHR21462:SF4 CELL SURFACE GLYCOPROTEIN OX2 RECEPTOR PRECURSOR CELL SURFACE GLYCOPROTEIN CD200 RECEPTOR 1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 regulation of defense response#GO:0031347;regulation of response to stimulus#GO:0048583;regulation of inflammatory response#GO:0050727;regulation of response to stress#GO:0080134;biological regulation#GO:0065007;negative regulation of response to external stimulus#GO:0032102;negative regulation of inflammatory response#GO:0050728;negative regulation of defense response#GO:0031348;negative regulation of response to stimulus#GO:0048585;regulation of immune system process#GO:0002682;regulation of response to external stimulus#GO:0032101;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519 side of membrane#GO:0098552;signaling receptor complex#GO:0043235;external side of plasma membrane#GO:0009897;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=2459|UniProtKB=P19784 P19784 CSNK2A2 PTHR24054:SF34 CASEIN KINASE II SUBUNIT ALPHA CASEIN KINASE II SUBUNIT ALPHA' transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 cellular response to stress#GO:0033554;DNA damage response#GO:0006974;regulation of chromosome segregation#GO:0051983;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of chromosome separation#GO:1905818;regulation of cell cycle#GO:0051726;regulation of cell cycle process#GO:0010564;biological regulation#GO:0065007;response to stress#GO:0006950;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789 membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular protein-containing complex#GO:0140535;protein kinase complex#GO:1902911;transferase complex#GO:1990234;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;cytosol#GO:0005829;nucleus#GO:0005634 Cadherin signaling pathway#P00012>Casein kinase II#P00462;Parkinson disease#P00049>Casein kinase II#P01236;Wnt signaling pathway#P00057>Casein Kinase 2#P01459 HUMAN|HGNC=779|UniProtKB=Q86WG3 Q86WG3 ATCAY PTHR12112:SF9 BNIP - RELATED CAYTAXIN programmed cell death#GO:0012501;cellular process#GO:0009987;cell death#GO:0008219;apoptotic process#GO:0006915 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 phosphodiesterase#PC00185;metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HUMAN|HGNC=18011|UniProtKB=Q96G61 Q96G61 NUDT11 PTHR12629:SF35 DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE 3-BETA pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787 primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;small molecule catabolic process#GO:0044282;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;nucleoside phosphate catabolic process#GO:1901292;nucleotide metabolic process#GO:0009117;organophosphate catabolic process#GO:0046434;cellular process#GO:0009987;nucleobase-containing compound catabolic process#GO:0034655;organophosphate metabolic process#GO:0019637;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;nucleotide catabolic process#GO:0009166;alcohol metabolic process#GO:0006066;nucleobase-containing small molecule metabolic process#GO:0055086 nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 phosphatase#PC00181 HUMAN|HGNC=28898|UniProtKB=Q7Z4H4 Q7Z4H4 ADM2 PTHR23414:SF2 ADRENOMEDULLIN, ADM PROTEIN ADM2 signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677;hormone activity#GO:0005179;molecular function regulator activity#GO:0098772 regulation of system process#GO:0044057;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;system process#GO:0003008;regulation of systemic arterial blood pressure#GO:0003073;regulation of blood pressure#GO:0008217;renal system process#GO:0003014;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;multicellular organismal process#GO:0032501;blood circulation#GO:0008015;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;circulatory system process#GO:0003013;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;regulation of biological quality#GO:0065008;positive regulation of multicellular organismal process#GO:0051240;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of body fluid levels#GO:0050878;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of heart contraction#GO:0008016;signaling#GO:0023052 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207;peptide hormone#PC00179 HUMAN|HGNC=19166|UniProtKB=Q92609 Q92609 TBC1D5 PTHR22957:SF337 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN TBC1 DOMAIN FAMILY MEMBER 5 enzyme regulator activity#GO:0030234;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047 cytosolic transport#GO:0016482;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;retrograde transport, endosome to Golgi#GO:0042147;endosomal transport#GO:0016197;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;transport#GO:0006810;intracellular transport#GO:0046907 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;retromer complex#GO:0030904;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endosome membrane#GO:0010008;endosome#GO:0005768;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;vesicle membrane#GO:0012506;membrane#GO:0016020;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;Golgi apparatus#GO:0005794 protein-binding activity modulator#PC00095;G-protein modulator#PC00022;GTPase-activating protein#PC00257 HUMAN|HGNC=19217|UniProtKB=Q6YHU6 Q6YHU6 THADA PTHR14387:SF7 THADA/DEATH RECEPTOR INTERACTING PROTEIN TRNA (32-2'-O)-METHYLTRANSFERASE REGULATOR THADA enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 RNA metabolic process#GO:0016070;methylation#GO:0032259;nucleic acid biosynthetic process#GO:0141187;macromolecule methylation#GO:0043414;inorganic ion homeostasis#GO:0098771;RNA modification#GO:0009451;calcium ion homeostasis#GO:0055074;tRNA modification#GO:0006400;intracellular monoatomic ion homeostasis#GO:0006873;intracellular calcium ion homeostasis#GO:0006874;tRNA processing#GO:0008033;chemical homeostasis#GO:0048878;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;tRNA methylation#GO:0030488;monoatomic ion homeostasis#GO:0050801;RNA methylation#GO:0001510;macromolecule modification#GO:0043412;RNA biosynthetic process#GO:0032774;homeostatic process#GO:0042592;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;macromolecule metabolic process#GO:0043170;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;macromolecule biosynthetic process#GO:0009059 scaffold/adaptor protein#PC00226 HUMAN|HGNC=26091|UniProtKB=Q53H54 Q53H54 TYW2 PTHR23245:SF25 TRNA METHYLTRANSFERASE TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 2 HOMOLOG methyltransferase activity#GO:0008168;catalytic activity, acting on a tRNA#GO:0140101;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on RNA#GO:0140098;RNA methyltransferase activity#GO:0008173;tRNA methyltransferase activity#GO:0008175 nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;gene expression#GO:0010467;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;tRNA methylation#GO:0030488;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;carbohydrate derivative biosynthetic process#GO:1901137;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;RNA biosynthetic process#GO:0032774;tRNA modification#GO:0006400;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;macromolecule modification#GO:0043412;RNA methylation#GO:0001510;RNA metabolic process#GO:0016070;methylation#GO:0032259;macromolecule methylation#GO:0043414;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 RNA methyltransferase#PC00033 HUMAN|HGNC=26444|UniProtKB=Q96N76 Q96N76 UROC1 PTHR12216:SF3 UROCANATE HYDRATASE UROCANATE HYDRATASE catalytic activity#GO:0003824;hydro-lyase activity#GO:0016836;lyase activity#GO:0016829;carbon-oxygen lyase activity#GO:0016835 metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;small molecule catabolic process#GO:0044282;amino acid metabolic process#GO:0006520;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;proteinogenic amino acid metabolic process#GO:0170039 hydratase#PC00120 HUMAN|HGNC=21391|UniProtKB=Q9P0V8 Q9P0V8 SLAMF8 PTHR12080:SF92 SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE SLAM FAMILY MEMBER 8 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;immune response#GO:0006955;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;immune system process#GO:0002376;cell communication#GO:0007154 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=3616|UniProtKB=P12318 P12318 FCGR2A PTHR11481:SF106 IMMUNOGLOBULIN FC RECEPTOR LOW AFFINITY IMMUNOGLOBULIN GAMMA FC REGION RECEPTOR II-A signaling receptor activity#GO:0038023;protein-containing complex binding#GO:0044877;immune receptor activity#GO:0140375;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488 inflammatory response#GO:0006954;acute inflammatory response#GO:0002526;positive regulation of biosynthetic process#GO:0009891;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of macromolecule metabolic process#GO:0060255;positive regulation of cytokine production#GO:0001819;regulation of cellular process#GO:0050794;cell killing#GO:0001906;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;defense response#GO:0006952;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;immune response#GO:0006955;regulation of cytokine production#GO:0001817;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;adaptive immune response#GO:0002250;positive regulation of endocytosis#GO:0045807;positive regulation of cellular component organization#GO:0051130;immune system process#GO:0002376;immunoglobulin mediated immune response#GO:0016064;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;regulation of biological process#GO:0050789;positive regulation of multicellular organismal process#GO:0051240;leukocyte mediated cytotoxicity#GO:0001909;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular component organization#GO:0051128;regulation of endocytosis#GO:0030100;cell surface receptor signaling pathway#GO:0007166;immune effector process#GO:0002252;regulation of transport#GO:0051049;regulation of localization#GO:0032879;positive regulation of biological process#GO:0048518;positive regulation of transport#GO:0051050;signal transduction#GO:0007165;cellular process#GO:0009987;response to stress#GO:0006950;regulation of multicellular organismal process#GO:0051239;positive regulation of macromolecule metabolic process#GO:0010604 membrane#GO:0016020;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;plasma membrane#GO:0005886 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=12157|UniProtKB=A0A5B9 A0A5B9 TRBC2 PTHR23411:SF32 TAPASIN T CELL RECEPTOR BETA CONSTANT 2 signaling receptor complex#GO:0043235;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886 immunoglobulin receptor superfamily#PC00124 T cell activation#P00053>TCR Beta#P01299 HUMAN|HGNC=9223|UniProtKB=Q06416 Q06416 POU5F1B PTHR11636:SF86 POU DOMAIN POU DOMAIN, CLASS 5, TRANSCRIPTION FACTOR 1-RELATED sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular anatomical structure#GO:0005622;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=25491|UniProtKB=Q9P2Q2 Q9P2Q2 FRMD4A PTHR46079:SF3 FERM DOMAIN-CONTAINING PROTEIN 4 FERM DOMAIN-CONTAINING PROTEIN 4A cell-cell junction#GO:0005911;bicellular tight junction#GO:0005923;cellular anatomical structure#GO:0110165;apical junction complex#GO:0043296;cell junction#GO:0030054;tight junction#GO:0070160;adherens junction#GO:0005912;anchoring junction#GO:0070161 HUMAN|HGNC=9966|UniProtKB=Q13127 Q13127 REST PTHR24403:SF102 ZINC FINGER PROTEIN RE1-SILENCING TRANSCRIPTION FACTOR transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription repressor activity#GO:0001217;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;nucleic acid binding#GO:0003676;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of developmental process#GO:0050793;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of cell differentiation#GO:0045595;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of neuron differentiation#GO:0045664 intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;transcription repressor complex#GO:0017053;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HUMAN|HGNC=24574|UniProtKB=Q9NUQ6 Q9NUQ6 SPATS2L PTHR15623:SF8 SPERMATOGENESIS-ASSOCIATED SERINE-RICH PROTEIN 2-RELATED SPATS2-LIKE PROTEIN cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=2896|UniProtKB=P10515 P10515 DLAT PTHR23151:SF94 DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;acetyltransferase activity#GO:0016407;transferase activity#GO:0016740;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity, acting on a protein#GO:0140096 carboxylic acid metabolic process#GO:0019752;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;monocarboxylic acid metabolic process#GO:0032787;purine-containing compound metabolic process#GO:0072521;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;pyruvate metabolic process#GO:0006090;oxoacid metabolic process#GO:0043436;acetyl-CoA metabolic process#GO:0006084;purine-containing compound biosynthetic process#GO:0072522;organophosphate biosynthetic process#GO:0090407;cellular respiration#GO:0045333;aerobic respiration#GO:0009060;sulfur compound metabolic process#GO:0006790;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091;energy derivation by oxidation of organic compounds#GO:0015980;nucleoside phosphate biosynthetic process#GO:1901293;acyl-CoA metabolic process#GO:0006637;nucleobase-containing small molecule metabolic process#GO:0055086 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;oxidoreductase complex#GO:1990204;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;acetyltransferase complex#GO:1902493;transferase complex#GO:1990234;intracellular organelle#GO:0043229;catalytic complex#GO:1902494 transferase#PC00220;acetyltransferase#PC00038 HUMAN|HGNC=26226|UniProtKB=Q5TGS1 Q5TGS1 HES3 PTHR10985:SF5 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED TRANSCRIPTION FACTOR HES-3 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of multicellular organismal process#GO:0051239;negative regulation of macromolecule biosynthetic process#GO:0010558;multicellular organism development#GO:0007275;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;anterior/posterior pattern specification#GO:0009952;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;regulation of multicellular organismal development#GO:2000026;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regionalization#GO:0003002;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cell development#GO:0060284;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of cell differentiation#GO:0045595;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of neurogenesis#GO:0050767;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of nervous system development#GO:0051960;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;pattern specification process#GO:0007389 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=8554|UniProtKB=P11940 P11940 PABPC1 PTHR24012:SF409 RNA BINDING PROTEIN POLYADENYLATE-BINDING PROTEIN 1 mRNA binding#GO:0003729;poly(A) binding#GO:0008143;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA 3'-UTR binding#GO:0003730;single-stranded RNA binding#GO:0003727;RNA binding#GO:0003723 post-transcriptional regulation of gene expression#GO:0010608;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007 intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasmic stress granule#GO:0010494;membraneless organelle#GO:0043228;nucleus#GO:0005634;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080 RNA metabolism protein#PC00031 HUMAN|HGNC=25205|UniProtKB=Q8WVF2 Q8WVF2 UCMA PTHR28647:SF2 UNIQUE CARTILAGE MATRIX-ASSOCIATED PROTEIN UNIQUE CARTILAGE MATRIX-ASSOCIATED PROTEIN chordate embryonic development#GO:0043009;animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502;embryo development ending in birth or egg hatching#GO:0009792;multicellular organism development#GO:0007275;skeletal system development#GO:0001501;anatomical structure development#GO:0048856;system development#GO:0048731;multicellular organismal process#GO:0032501;embryo development#GO:0009790 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 HUMAN|HGNC=5057|UniProtKB=O43763 O43763 TLX2 PTHR45921:SF3 IP01054P T-CELL LEUKEMIA HOMEOBOX PROTEIN 2 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;animal organ development#GO:0048513;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;animal gross anatomical part developmental process#GO:0160108 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=1075|UniProtKB=P34820 P34820 BMP8B PTHR11848:SF119 TGF-BETA FAMILY BONE MORPHOGENETIC PROTEIN 8A-RELATED molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677;cytokine activity#GO:0005125;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018 multicellular organism development#GO:0007275;animal organ development#GO:0048513;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;cellular response to BMP stimulus#GO:0071773;response to BMP#GO:0071772;developmental process#GO:0032502;cell surface receptor signaling pathway#GO:0007166;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;heart development#GO:0007507;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;signal transduction#GO:0007165;cellular process#GO:0009987;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;cellular response to growth factor stimulus#GO:0071363;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;circulatory system development#GO:0072359;response to stimulus#GO:0050896;response to growth factor#GO:0070848;cellular response to endogenous stimulus#GO:0071495;regulation of cellular process#GO:0050794;signaling#GO:0023052;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;BMP signaling pathway#GO:0030509;cellular response to stimulus#GO:0051716 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 growth factor#PC00112 TGF-beta signaling pathway#P00052>TGFbeta#P01286 HUMAN|HGNC=24950|UniProtKB=Q6UWP8 Q6UWP8 SBSN PTHR23243:SF3 SUPRABASAL-SPECIFIC PROTEIN SUPRABASIN SUPRABASIN HUMAN|HGNC=8898|UniProtKB=P07205 P07205 PGK2 PTHR11406:SF10 PHOSPHOGLYCERATE KINASE PHOSPHOGLYCERATE KINASE 2 catalytic activity#GO:0003824;phosphotransferase activity, carboxyl group as acceptor#GO:0016774;transferase activity, transferring phosphorus-containing groups#GO:0016772;nucleotide binding#GO:0000166;anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167;phosphoglycerate kinase activity#GO:0004618;transferase activity#GO:0016740;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;carbohydrate derivative binding#GO:0097367;kinase activity#GO:0016301;ribonucleotide binding#GO:0032553;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;ATP binding#GO:0005524;binding#GO:0005488;nucleoside phosphate binding#GO:1901265 small molecule biosynthetic process#GO:0044283;nucleotide catabolic process#GO:0009166;energy derivation by oxidation of organic compounds#GO:0015980;ribonucleotide catabolic process#GO:0009261;carbohydrate derivative metabolic process#GO:1901135;nucleobase-containing compound catabolic process#GO:0034655;nucleobase-containing compound metabolic process#GO:0006139;purine nucleotide catabolic process#GO:0006195;organophosphate catabolic process#GO:0046434;ribonucleoside diphosphate catabolic process#GO:0009191;cellular respiration#GO:0045333;purine ribonucleotide catabolic process#GO:0009154;hexose biosynthetic process#GO:0019319;nucleoside diphosphate catabolic process#GO:0009134;carbohydrate metabolic process#GO:0005975;nucleoside phosphate metabolic process#GO:0006753;catabolic process#GO:0009056;metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;monosaccharide metabolic process#GO:0005996;purine-containing compound catabolic process#GO:0072523;glucose metabolic process#GO:0006006;nicotinamide nucleotide metabolic process#GO:0046496;gluconeogenesis#GO:0006094;ATP metabolic process#GO:0046034;oxoacid metabolic process#GO:0043436;ribonucleoside diphosphate metabolic process#GO:0009185;phosphorus metabolic process#GO:0006793;carboxylic acid metabolic process#GO:0019752;pyridine nucleotide catabolic process#GO:0019364;small molecule metabolic process#GO:0044281;generation of precursor metabolites and energy#GO:0006091;purine ribonucleoside diphosphate metabolic process#GO:0009179;ADP metabolic process#GO:0046031;glycolytic process#GO:0006096;purine ribonucleoside triphosphate metabolic process#GO:0009205;organophosphate metabolic process#GO:0019637;biosynthetic process#GO:0009058;monosaccharide biosynthetic process#GO:0046364;pyridine-containing compound metabolic process#GO:0072524;nucleoside diphosphate metabolic process#GO:0009132;aerobic respiration#GO:0009060;purine ribonucleoside diphosphate catabolic process#GO:0009181;purine nucleoside triphosphate metabolic process#GO:0009144;primary metabolic process#GO:0044238;hexose metabolic process#GO:0019318;carbohydrate derivative catabolic process#GO:1901136;nucleoside triphosphate metabolic process#GO:0009141;nucleoside phosphate catabolic process#GO:1901292;ADP catabolic process#GO:0046032;nucleobase-containing small molecule metabolic process#GO:0055086;purine nucleoside diphosphate catabolic process#GO:0009137;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;carbohydrate biosynthetic process#GO:0016051;ribonucleotide metabolic process#GO:0009259;purine nucleoside diphosphate metabolic process#GO:0009135;carbohydrate catabolic process#GO:0016052;nucleotide metabolic process#GO:0009117;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;pyridine-containing compound catabolic process#GO:0072526;monocarboxylic acid metabolic process#GO:0032787;pyruvate metabolic process#GO:0006090 cellular anatomical structure#GO:0110165;sperm flagellum#GO:0036126;motile cilium#GO:0031514;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;cell projection#GO:0042995;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cilium#GO:0005929;9+2 motile cilium#GO:0097729 carbohydrate kinase#PC00065 HUMAN|HGNC=1364|UniProtKB=Q9NX38 Q9NX38 ABITRAM PTHR13651:SF1 PROTEIN ABITRAM PROTEIN ABITRAM binding#GO:0005488;actin monomer binding#GO:0003785;cytoskeletal protein binding#GO:0008092;actin filament binding#GO:0051015;actin binding#GO:0003779;protein binding#GO:0005515;protein-containing complex binding#GO:0044877 neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;regulation of anatomical structure size#GO:0090066;cell projection morphogenesis#GO:0048858;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;neuron projection development#GO:0031175;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;regulation of actin cytoskeleton organization#GO:0032956;generation of neurons#GO:0048699;regulation of actin filament length#GO:0030832;animal gross anatomical part developmental process#GO:0160108;neuron development#GO:0048666;regulation of biological quality#GO:0065008;dendrite development#GO:0016358;regulation of cellular component size#GO:0032535;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;regulation of protein-containing complex assembly#GO:0043254;cellular component organization#GO:0016043;cell development#GO:0048468;regulation of cellular component biogenesis#GO:0044087;regulation of plasma membrane bounded cell projection assembly#GO:0120032;regulation of cellular component organization#GO:0051128;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell morphogenesis#GO:0000902;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;regulation of cell projection organization#GO:0031344;regulation of actin filament-based process#GO:0032970;regulation of filopodium assembly#GO:0051489;neurogenesis#GO:0022008;regulation of plasma membrane bounded cell projection organization#GO:0120035;cellular developmental process#GO:0048869;regulation of actin filament organization#GO:0110053;regulation of actin polymerization or depolymerization#GO:0008064;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;regulation of actin filament polymerization#GO:0030833;multicellular organismal process#GO:0032501;system development#GO:0048731;regulation of cell projection assembly#GO:0060491;anatomical structure development#GO:0048856;regulation of supramolecular fiber organization#GO:1902903;dendrite morphogenesis#GO:0048813;regulation of protein polymerization#GO:0032271;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794 membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;somatodendritic compartment#GO:0036477;intracellular membraneless organelle#GO:0043232;lamellipodium#GO:0030027;nucleus#GO:0005634;neuron projection#GO:0043005;cell leading edge#GO:0031252;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;dendritic tree#GO:0097447;intracellular organelle#GO:0043229;dendrite#GO:0030425;filopodium#GO:0030175;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;actin-based cell projection#GO:0098858;actin cytoskeleton#GO:0015629 HUMAN|HGNC=17513|UniProtKB=Q9NSB8 Q9NSB8 HOMER2 PTHR10918:SF2 HOMER HOMER PROTEIN HOMOLOG 2 signaling receptor binding#GO:0005102;binding#GO:0005488;G protein-coupled receptor binding#GO:0001664;protein binding#GO:0005515 cell surface receptor signaling pathway#GO:0007166;regulation of transport#GO:0051049;system process#GO:0003008;regulation of localization#GO:0032879;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of monoatomic ion transport#GO:0043269;multicellular organismal process#GO:0032501;regulation of calcium ion transport#GO:0051924;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;sensory perception of mechanical stimulus#GO:0050954;sensory perception#GO:0007600;nervous system process#GO:0050877;cell communication#GO:0007154;glutamate receptor signaling pathway#GO:0007215;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;regulation of metal ion transport#GO:0010959;sensory perception of sound#GO:0007605;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052 dendrite#GO:0030425;dendritic tree#GO:0097447;postsynaptic density#GO:0014069;intracellular anatomical structure#GO:0005622;postsynapse#GO:0098794;asymmetric synapse#GO:0032279;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cell junction#GO:0030054;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;postsynaptic specialization#GO:0099572;neuron to neuron synapse#GO:0098984;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;cytoplasm#GO:0005737 HUMAN|HGNC=19881|UniProtKB=Q9BXX0 Q9BXX0 EMILIN2 PTHR15427:SF5 EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER EMILIN-2 extracellular matrix structural constituent#GO:0005201;structural molecule activity#GO:0005198 regulation of angiogenesis#GO:0045765;regulation of platelet activation#GO:0010543;regulation of cellular process#GO:0050794;regulation of cell-cell adhesion#GO:0022407;regulation of developmental process#GO:0050793;positive regulation of cell adhesion#GO:0045785;regulation of vasculature development#GO:1901342;regulation of response to stress#GO:0080134;regulation of response to stimulus#GO:0048583;positive regulation of developmental process#GO:0051094;regulation of cell adhesion#GO:0030155;positive regulation of response to stimulus#GO:0048584;regulation of coagulation#GO:0050818;biological regulation#GO:0065007;regulation of hemostasis#GO:1900046;positive regulation of cellular process#GO:0048522;regulation of biological quality#GO:0065008;regulation of platelet aggregation#GO:0090330;positive regulation of coagulation#GO:0050820;regulation of body fluid levels#GO:0050878;regulation of blood coagulation#GO:0030193;regulation of wound healing#GO:0061041;positive regulation of angiogenesis#GO:0045766;regulation of cell activation#GO:0050865;regulation of multicellular organismal development#GO:2000026;positive regulation of multicellular organismal process#GO:0051240;regulation of biological process#GO:0050789;regulation of anatomical structure morphogenesis#GO:0022603;regulation of response to external stimulus#GO:0032101;regulation of multicellular organismal process#GO:0051239;positive regulation of cell-cell adhesion#GO:0022409;regulation of response to wounding#GO:1903034;positive regulation of biological process#GO:0048518 extracellular region#GO:0005576;extracellular protein-containing complex#GO:0140392;supramolecular fiber#GO:0099512;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;protein complex involved in cell adhesion#GO:0098636;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;interstitial matrix#GO:0005614;supramolecular complex#GO:0099080 scaffold/adaptor protein#PC00226 HUMAN|HGNC=23329|UniProtKB=Q8TF47 Q8TF47 ZFP90 PTHR24381:SF143 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 90 HOMOLOG sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690 regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=26506|UniProtKB=Q96MI6 Q96MI6 PPM1M PTHR13832:SF236 PROTEIN PHOSPHATASE 2C PROTEIN PHOSPHATASE 1M phosphoprotein phosphatase activity#GO:0004721;protein serine/threonine phosphatase activity#GO:0004722;hydrolase activity#GO:0016787;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;cell communication#GO:0007154 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739 protein phosphatase#PC00195 HUMAN|HGNC=29316|UniProtKB=Q9HCJ5 Q9HCJ5 ZSWIM6 PTHR22619:SF3 ZINC FINGER SWIM DOMAIN CONTAINING PROTEIN 4, 5, 6 ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 6 ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535;catalytic complex#GO:1902494;transferase complex#GO:1990234;Cul2-RING ubiquitin ligase complex#GO:0031462 HUMAN|HGNC=18415|UniProtKB=O75146 O75146 HIP1R PTHR10407:SF10 HUNTINGTIN INTERACTING PROTEIN 1 HUNTINGTIN-INTERACTING PROTEIN 1-RELATED PROTEIN actin filament binding#GO:0051015;actin binding#GO:0003779;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;protein-containing complex binding#GO:0044877;lipid binding#GO:0008289;protein-membrane adaptor activity#GO:0043495;protein binding#GO:0005515;cytoskeletal adaptor activity#GO:0008093;cytoskeletal protein binding#GO:0008092;phospholipid binding#GO:0005543;molecular adaptor activity#GO:0060090;phosphatidylinositol phosphate binding#GO:1901981 actin filament-based process#GO:0030029;localization#GO:0051179;supramolecular fiber organization#GO:0097435;positive regulation of signal transduction#GO:0009967;regulation of ERBB signaling pathway#GO:1901184;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;actin cytoskeleton organization#GO:0030036;regulation of cell communication#GO:0010646;regulation of response to stimulus#GO:0048583;transport#GO:0006810;establishment of localization#GO:0051234;actin filament organization#GO:0007015;positive regulation of cellular process#GO:0048522;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of epidermal growth factor receptor signaling pathway#GO:0042058;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;regulation of programmed cell death#GO:0043067;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;regulation of biological process#GO:0050789;endocytosis#GO:0006897;regulation of apoptotic process#GO:0042981;cellular component organization or biogenesis#GO:0071840;import into cell#GO:0098657;protein-containing complex organization#GO:0043933;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;coated vesicle#GO:0030135;actin cytoskeleton#GO:0015629;intracellular vesicle#GO:0097708;cortical cytoskeleton#GO:0030863;cell cortex#GO:0005938;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;clathrin-coated vesicle#GO:0030136;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;cell periphery#GO:0071944;intracellular membraneless organelle#GO:0043232;cortical actin cytoskeleton#GO:0030864;cytoplasm#GO:0005737 cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 Huntington disease#P00029>Hip-12#P00763 HUMAN|HGNC=13913|UniProtKB=Q96MA1 Q96MA1 DMRTB1 PTHR12322:SF66 DOUBLESEX AND MAB-3 RELATED TRANSCRIPTION FACTOR DMRT DOUBLESEX- AND MAB-3-RELATED TRANSCRIPTION FACTOR B1 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 developmental process#GO:0032502;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;sex differentiation#GO:0007548;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;developmental process involved in reproduction#GO:0003006;reproductive process#GO:0022414;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218 HUMAN|HGNC=26076|UniProtKB=Q9NWR8 Q9NWR8 MCUB PTHR13462:SF6 CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL CALCIUM UNIPORTER REGULATORY SUBUNIT MCUB, MITOCHONDRIAL transporter regulator activity#GO:0141108;channel activity#GO:0015267;channel regulator activity#GO:0016247;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;passive transmembrane transporter activity#GO:0022803;ion channel regulator activity#GO:0099106;active transmembrane transporter activity#GO:0022804;molecular function regulator activity#GO:0098772;monoatomic cation channel activity#GO:0005261;monoatomic cation transmembrane transporter activity#GO:0008324;molecular function inhibitor activity#GO:0140678;calcium ion transmembrane transporter activity#GO:0015085;secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;ion channel inhibitor activity#GO:0008200;calcium channel regulator activity#GO:0005246;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216 calcium ion homeostasis#GO:0055074;inorganic ion homeostasis#GO:0098771;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;intracellular monoatomic ion homeostasis#GO:0006873;calcium ion transmembrane transport#GO:0070588;mitochondrial calcium ion homeostasis#GO:0051560;metal ion transport#GO:0030001;homeostatic process#GO:0042592;intracellular monoatomic cation homeostasis#GO:0030003;transport#GO:0006810;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;establishment of localization#GO:0051234;cellular homeostasis#GO:0019725;calcium ion transport#GO:0006816;intracellular calcium ion homeostasis#GO:0006874;intracellular chemical homeostasis#GO:0055082;monoatomic ion homeostasis#GO:0050801;mitochondrial calcium ion transmembrane transport#GO:0006851;cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655 calcium channel complex#GO:0034704;mitochondrion#GO:0005739;membrane protein complex#GO:0098796;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transmembrane transporter complex#GO:1902495;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;mitochondrial protein-containing complex#GO:0098798;inner mitochondrial membrane protein complex#GO:0098800;cation channel complex#GO:0034703;organelle membrane#GO:0031090;transporter complex#GO:1990351 HUMAN|HGNC=33499|UniProtKB=Q8WXE1 Q8WXE1 ATRIP PTHR28594:SF1 ATR-INTERACTING PROTEIN ATR-INTERACTING PROTEIN cellular response to stimulus#GO:0051716;cellular process#GO:0009987;primary metabolic process#GO:0044238;response to stress#GO:0006950;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound metabolic process#GO:0006139;response to stimulus#GO:0050896;DNA damage response#GO:0006974;cellular response to stress#GO:0033554;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;macromolecule metabolic process#GO:0043170 HUMAN|HGNC=29270|UniProtKB=Q9P2E5 Q9P2E5 CHPF2 PTHR12369:SF14 CHONDROITIN SYNTHASE CHONDROITIN POLYMERIZING FACTOR 2, NON-CATALYTIC SUBUNIT glycosyltransferase activity#GO:0016757;acetylgalactosaminyltransferase activity#GO:0008376;UDP-glycosyltransferase activity#GO:0008194;structural molecule activity#GO:0005198;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein complex scaffold activity#GO:0140378;hexosyltransferase activity#GO:0016758 primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;protein O-linked glycosylation#GO:0006493;chondroitin sulfate proteoglycan metabolic process#GO:0050654;macromolecule biosynthetic process#GO:0009059;glycoprotein biosynthetic process#GO:0009101;proteoglycan biosynthetic process#GO:0030166;biosynthetic process#GO:0009058;chondroitin sulfate proteoglycan biosynthetic process#GO:0050650;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;proteoglycan metabolic process#GO:0006029;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137 glycosyltransferase#PC00111 HUMAN|HGNC=17868|UniProtKB=Q96PG8 Q96PG8 BBC3 PTHR28639:SF1 BCL-2-BINDING COMPONENT 3 BCL-2-BINDING COMPONENT 3, ISOFORMS 3_4 regulation of release of cytochrome c from mitochondria#GO:0090199;response to endoplasmic reticulum stress#GO:0034976;cellular response to stress#GO:0033554;positive regulation of cellular component organization#GO:0051130;cell communication#GO:0007154;positive regulation of organelle organization#GO:0010638;intrinsic apoptotic signaling pathway#GO:0097193;intracellular signal transduction#GO:0035556;programmed cell death#GO:0012501;execution phase of apoptosis#GO:0097194;regulation of mitochondrion organization#GO:0010821;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;cell death#GO:0008219;cellular response to stimulus#GO:0051716;apoptotic process#GO:0006915;response to stimulus#GO:0050896;regulation of cellular component organization#GO:0051128;intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress#GO:0070059;regulation of cellular process#GO:0050794;signaling#GO:0023052;apoptotic signaling pathway#GO:0097190;response to stress#GO:0006950;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;biological regulation#GO:0065007 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=17169|UniProtKB=Q13162 Q13162 PRDX4 PTHR10681:SF180 THIOREDOXIN PEROXIDASE PEROXIREDOXIN-4 catalytic activity#GO:0003824;peroxidase activity#GO:0004601;antioxidant activity#GO:0016209;oxidoreductase activity, acting on peroxide as acceptor#GO:0016684;oxidoreductase activity#GO:0016491 cellular homeostasis#GO:0019725;cell redox homeostasis#GO:0045454;response to oxidative stress#GO:0006979;reactive oxygen species metabolic process#GO:0072593;metabolic process#GO:0008152;hydrogen peroxide metabolic process#GO:0042743;homeostatic process#GO:0042592;catabolic process#GO:0009056;response to stimulus#GO:0050896;cellular process#GO:0009987;response to stress#GO:0006950 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 peroxidase#PC00180;oxidoreductase#PC00176 HUMAN|HGNC=15559|UniProtKB=Q8WYQ3 Q8WYQ3 CHCHD10 PTHR13523:SF4 COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2/NUR77 COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 10, MITOCHONDRIAL mitochondrion organization#GO:0007005;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043 nucleus#GO:0005634;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=27346|UniProtKB=Q5VV17 Q5VV17 OTUD1 PTHR12419:SF101 OTU DOMAIN CONTAINING PROTEIN OTU DOMAIN-CONTAINING PROTEIN 1 ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;cysteine-type peptidase activity#GO:0008234;cysteine-type deubiquitinase activity#GO:0004843;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005 cysteine protease#PC00081 HUMAN|HGNC=4061|UniProtKB=O43826 O43826 SLC37A4 PTHR43826:SF3 GLUCOSE-6-PHOSPHATE EXCHANGER SLC37A4 GLUCOSE-6-PHOSPHATE EXCHANGER SLC37A4 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;antiporter activity#GO:0015297;active transmembrane transporter activity#GO:0022804;phosphate transmembrane transporter activity#GO:0005315;carbohydrate derivative transmembrane transporter activity#GO:1901505;organophosphate ester transmembrane transporter activity#GO:0015605 phosphate ion transport#GO:0006817;organophosphate ester transport#GO:0015748;carbohydrate derivative transport#GO:1901264;cellular process#GO:0009987;inorganic anion transport#GO:0015698;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810 intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020 primary active transporter#PC00068 HUMAN|HGNC=33699|UniProtKB=Q587J8 Q587J8 KHDC3L PTHR19447:SF15 OOCYTE-EXPRESSED PROTEIN HOMOLOG-RELATED KH DOMAIN-CONTAINING PROTEIN 3 HUMAN|HGNC=3345|UniProtKB=O14682 O14682 ENC1 PTHR24410:SF5 HL07962P-RELATED ECTODERM-NEURAL CORTEX PROTEIN 1 ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941 intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;Cul3-RING ubiquitin ligase complex#GO:0031463;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;transferase complex#GO:1990234;cullin-RING ubiquitin ligase complex#GO:0031461;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 defense/immunity protein#PC00090 HUMAN|HGNC=14788|UniProtKB=Q8NGH6 Q8NGH6 OR52L2P PTHR26450:SF353 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 52L2-RELATED olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=16343|UniProtKB=A0A0G2JN01 A0A0G2JN01 KIR3DP1 PTHR11738:SF168 MHC CLASS I NK CELL RECEPTOR IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;immune receptor activity#GO:0140375;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;regulation of immune response#GO:0050776;cell surface receptor signaling pathway#GO:0007166;regulation of response to stimulus#GO:0048583;biological regulation#GO:0065007;signaling#GO:0023052;immune response-regulating cell surface receptor signaling pathway#GO:0002768;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;signal transduction#GO:0007165;regulation of biological process#GO:0050789;immune response-regulating signaling pathway#GO:0002764;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=18875|UniProtKB=P59537 P59537 TAS2R43 PTHR11394:SF127 TASTE RECEPTOR TYPE 2 TASTE RECEPTOR TYPE 2 MEMBER 43 bitter taste receptor activity#GO:0033038;molecular transducer activity#GO:0060089;taste receptor activity#GO:0008527;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 sensory perception of bitter taste#GO:0050913;detection of chemical stimulus#GO:0009593;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;response to stimulus#GO:0050896;response to chemical#GO:0042221;multicellular organismal process#GO:0032501;sensory perception#GO:0007600;detection of chemical stimulus involved in sensory perception of taste#GO:0050912;nervous system process#GO:0050877;sensory perception of taste#GO:0050909;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;system process#GO:0003008;detection of chemical stimulus involved in sensory perception of bitter taste#GO:0001580 cellular anatomical structure#GO:0110165;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=30253|UniProtKB=O14569 O14569 CYB561D2 PTHR15422:SF21 OS05G0565100 PROTEIN TRANSMEMBRANE REDUCTASE CYB561D2 oxidoreductase activity#GO:0016491;tetrapyrrole binding#GO:0046906;binding#GO:0005488;catalytic activity#GO:0003824;heme binding#GO:0020037 chemical homeostasis#GO:0048878;carbohydrate homeostasis#GO:0033500;homeostatic process#GO:0042592 HUMAN|HGNC=16641|UniProtKB=Q86UU9 Q86UU9 TAC4 PTHR11250:SF2 TACHYKININ TACHYKININ-4 protein binding#GO:0005515;G protein-coupled receptor binding#GO:0001664;neuropeptide receptor binding#GO:0071855;binding#GO:0005488;signaling receptor binding#GO:0005102 inflammatory response#GO:0006954;G protein-coupled receptor signaling pathway#GO:0007186;positive regulation of cytosolic calcium ion concentration#GO:0007204;regulation of biological quality#GO:0065008;defense response#GO:0006952;cell communication#GO:0007154;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stress#GO:0006950;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=2761|UniProtKB=P59665 P59665 DEFA1 PTHR11876:SF19 ALPHA-DEFENSIN 1 NEUTROPHIL DEFENSIN 1-RELATED antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;response to bacterium#GO:0009617;immune system process#GO:0002376;defense response to bacterium#GO:0042742;response to stimulus#GO:0050896;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;defense response to Gram-negative bacterium#GO:0050829;defense response to Gram-positive bacterium#GO:0050830;innate immune response#GO:0045087;antibacterial humoral response#GO:0019731;response to external stimulus#GO:0009605;defense response#GO:0006952;antimicrobial humoral response#GO:0019730;humoral immune response#GO:0006959;defense response to other organism#GO:0098542;response to other organism#GO:0051707;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;defense response to symbiont#GO:0140546;immune response#GO:0006955 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 antimicrobial response protein#PC00051 HUMAN|HGNC=24278|UniProtKB=Q5VST6 Q5VST6 ABHD17B PTHR12277:SF48 ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN ALPHA_BETA HYDROLASE DOMAIN-CONTAINING PROTEIN 17B catalytic activity#GO:0003824;thiolester hydrolase activity#GO:0016790;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;palmitoyl hydrolase activity#GO:0098599;catalytic activity, acting on a protein#GO:0140096 regulation of synapse organization#GO:0050807;regulation of protein localization#GO:0032880;regulation of localization#GO:0032879;regulation of biological quality#GO:0065008;regulation of synapse structure or activity#GO:0050803;regulation of biological process#GO:0050789;positive regulation of biological process#GO:0048518;regulation of postsynapse organization#GO:0099175;negative regulation of biological process#GO:0048519;biological regulation#GO:0065007;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794 intracellular organelle#GO:0043229;endosome#GO:0005768;endosome membrane#GO:0010008;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;cell periphery#GO:0071944;vesicle membrane#GO:0012506;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505 serine protease#PC00203 HUMAN|HGNC=13045|UniProtKB=Q9BRH9 Q9BRH9 ZNF251 PTHR24377:SF1025 IP01015P-RELATED ZINC FINGER PROTEIN 251 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=9505|UniProtKB=Q9UIA0 Q9UIA0 CYTH4 PTHR10663:SF323 GUANYL-NUCLEOTIDE EXCHANGE FACTOR CYTOHESIN-4 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=20594|UniProtKB=Q9UHF1 Q9UHF1 EGFL7 PTHR14949:SF21 EGF-LIKE-DOMAIN, MULTIPLE 7, 8 EPIDERMAL GROWTH FACTOR-LIKE PROTEIN 7 protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 developmental process#GO:0032502;vasculature development#GO:0001944;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;cellular process#GO:0009987;tube development#GO:0035295;vasculogenesis#GO:0001570;multicellular organismal process#GO:0032501;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;anatomical structure development#GO:0048856;anatomical structure morphogenesis#GO:0009653;tube morphogenesis#GO:0035239;blood vessel development#GO:0001568;blood vessel morphogenesis#GO:0048514;cell differentiation#GO:0030154;circulatory system development#GO:0072359 cellular anatomical structure#GO:0110165;cell surface#GO:0009986;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HUMAN|HGNC=14806|UniProtKB=Q8NGP4 Q8NGP4 OR5M3 PTHR48018:SF147 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5M3 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;signal transduction#GO:0007165;cellular process#GO:0009987;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;sensory perception#GO:0007600;nervous system process#GO:0050877;cell communication#GO:0007154;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;sensory perception of smell#GO:0007608;signaling#GO:0023052 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=15019|UniProtKB=P0C7T2 P0C7T2 OR2T7 PTHR26453:SF78 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2T27-RELATED transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;response to stimulus#GO:0050896;response to chemical#GO:0042221;detection of chemical stimulus#GO:0009593;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;system process#GO:0003008;nervous system process#GO:0050877;sensory perception#GO:0007600;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=2380|UniProtKB=P10915 P10915 HAPLN1 PTHR22804:SF10 AGGRECAN/VERSICAN PROTEOGLYCAN HYALURONAN AND PROTEOGLYCAN LINK PROTEIN 1 multicellular organismal process#GO:0032501;central nervous system development#GO:0007417;nervous system development#GO:0007399;anatomical structure development#GO:0048856;skeletal system development#GO:0001501;multicellular organism development#GO:0007275;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502 extracellular region#GO:0005576;cell junction#GO:0030054;cell periphery#GO:0071944;extracellular matrix#GO:0031012;membrane#GO:0016020;external encapsulating structure#GO:0030312;plasma membrane#GO:0005886;synapse#GO:0045202;cellular anatomical structure#GO:0110165 extracellular matrix glycoprotein#PC00100;extracellular matrix protein#PC00102 HUMAN|HGNC=14886|UniProtKB=Q9UDY4 Q9UDY4 DNAJB4 PTHR24078:SF288 DNAJ HOMOLOG SUBFAMILY C MEMBER DNAJ HOMOLOG SUBFAMILY B MEMBER 4 protein binding#GO:0005515;binding#GO:0005488;protein-folding chaperone binding#GO:0051087 negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;metabolic process#GO:0008152;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;protein maturation#GO:0051604;gene expression#GO:0010467;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;protein folding#GO:0006457;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;biosynthetic process#GO:0009058;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;protein metabolic process#GO:0019538;regulation of DNA-templated transcription#GO:0006355;primary metabolic process#GO:0044238;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 chaperone#PC00072 HUMAN|HGNC=25772|UniProtKB=Q6P1M9 Q6P1M9 ARMCX5 PTHR47081:SF2 FAMILY NOT NAMED ARMADILLO REPEAT-CONTAINING X-LINKED PROTEIN 5 HUMAN|HGNC=4377|UniProtKB=Q9P2T1 Q9P2T1 GMPR2 PTHR43170:SF4 GMP REDUCTASE GMP REDUCTASE 2 reductase#PC00198;oxidoreductase#PC00176 HUMAN|HGNC=25034|UniProtKB=Q5VZP5 Q5VZP5 STYXL2 PTHR45682:SF4 AGAP008228-PA SERINE_THREONINE_TYROSINE-INTERACTING-LIKE PROTEIN 2 catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;protein tyrosine/serine/threonine phosphatase activity#GO:0008138;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721 regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;negative regulation of biological process#GO:0048519;negative regulation of MAPK cascade#GO:0043409;regulation of biological process#GO:0050789;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;negative regulation of response to stimulus#GO:0048585;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of MAPK cascade#GO:0043408 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protein phosphatase#PC00195 Oxidative stress response#P00046>MKP5#P01131 HUMAN|HGNC=20883|UniProtKB=Q8N9F7 Q8N9F7 GDPD1 PTHR42758:SF1 PHOSPHATIDYLGLYCEROL PHOSPHOLIPASE C LYSOPHOSPHOLIPASE D GDPD1 hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689;phosphatidylcholine lysophospholipase A1 activity#GO:0004622;lipase activity#GO:0016298;phosphoric ester hydrolase activity#GO:0042578;phosphoric diester hydrolase activity#GO:0008081;phospholipase activity#GO:0120569;hydrolase activity, acting on ester bonds#GO:0016788;glycerophospholipase activity#GO:0004620;catalytic activity#GO:0003824 organophosphate catabolic process#GO:0046434;glycerolipid catabolic process#GO:0046503;catabolic process#GO:0009056;glycerolipid metabolic process#GO:0046486;small molecule metabolic process#GO:0044281;phospholipid catabolic process#GO:0009395;phospholipid metabolic process#GO:0006644;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;glycerophospholipid catabolic process#GO:0046475;alcohol metabolic process#GO:0006066;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;glycerophospholipid metabolic process#GO:0006650;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;lipid catabolic process#GO:0016042 membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020 hydrolase#PC00121;lipase#PC00143;phospholipase#PC00186 HUMAN|HGNC=639|UniProtKB=Q13520 Q13520 AQP6 PTHR19139:SF113 AQUAPORIN TRANSPORTER AQUAPORIN-6 water channel activity#GO:0015250;water transmembrane transporter activity#GO:0005372;gated channel activity#GO:0022836;chloride channel activity#GO:0005254;transporter activity#GO:0005215;monoatomic anion transmembrane transporter activity#GO:0008509;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;nitrate transmembrane transporter activity#GO:0015112;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic anion channel activity#GO:0005253;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;chloride transmembrane transporter activity#GO:0015108;transmembrane transporter activity#GO:0022857 transport#GO:0006810;establishment of localization#GO:0051234;localization#GO:0051179;water transport#GO:0006833;fluid transport#GO:0042044 vesicle#GO:0031982;intracellular vesicle#GO:0097708;apical plasma membrane#GO:0016324;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;cell periphery#GO:0071944;vesicle membrane#GO:0012506;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;plasma membrane region#GO:0098590;cytoplasmic vesicle membrane#GO:0030659;apical part of cell#GO:0045177;organelle membrane#GO:0031090 transporter#PC00227 HUMAN|HGNC=18424|UniProtKB=Q9HCK5 Q9HCK5 AGO4 PTHR22891:SF26 EUKARYOTIC TRANSLATION INITIATION FACTOR 2C PROTEIN ARGONAUTE-4 nuclease activity#GO:0004518;RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA nuclease activity#GO:0004540;endonuclease activity#GO:0004519;single-stranded RNA binding#GO:0003727;RNA endonuclease activity#GO:0004521;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;gene expression#GO:0010467;RNA processing#GO:0006396;nucleic acid biosynthetic process#GO:0141187;miRNA processing#GO:0035196;RNA metabolic process#GO:0016070;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of metabolic process#GO:0009892;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;regulatory ncRNA-mediated gene silencing#GO:0031047;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulatory ncRNA processing#GO:0070918;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;macromolecule biosynthetic process#GO:0009059;negative regulation of macromolecule metabolic process#GO:0010605;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;biosynthetic process#GO:0009058;biological regulation#GO:0065007;post-transcriptional gene silencing#GO:0016441;regulatory ncRNA-mediated post-transcriptional gene silencing#GO:0035194;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;pre-miRNA processing#GO:0031054;RNA biosynthetic process#GO:0032774 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;supramolecular complex#GO:0099080;organelle#GO:0043226;ribonucleoprotein granule#GO:0035770;cytoplasmic ribonucleoprotein granule#GO:0036464;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 translational protein#PC00263;translation factor#PC00223;translation initiation factor#PC00224 HUMAN|HGNC=26813|UniProtKB=Q8N8J7 Q8N8J7 FAM241A PTHR33690:SF1 DUF4605 DOMAIN-CONTAINING PROTEIN FAMILY WITH SEQUENCE SIMILARITY 241 MEMBER A intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=14455|UniProtKB=P0C5Z0 P0C5Z0 H2AB2 PTHR23430:SF23 HISTONE H2A HISTONE H2A-BBD TYPE 1-RELATED structural molecule activity#GO:0005198 negative regulation of cellular process#GO:0048523;cellular component organization or biogenesis#GO:0071840;negative regulation of gene expression, epigenetic#GO:0045814;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;cellular component assembly#GO:0022607;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;chromatin organization#GO:0006325;heterochromatin organization#GO:0070828;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;heterochromatin formation#GO:0031507;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;nucleosome#GO:0000786;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-DNA complex#GO:0032993;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=5742|UniProtKB=A0A0C4DH72 A0A0C4DH72 IGKV1-6 PTHR23267:SF502 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN KAPPA VARIABLE 1-6 response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=14472|UniProtKB=Q9BXS9 Q9BXS9 SLC26A6 PTHR11814:SF113 SULFATE TRANSPORTER SOLUTE CARRIER FAMILY 26 MEMBER 6 chloride transmembrane transporter activity#GO:0015108;bicarbonate transmembrane transporter activity#GO:0015106;antiporter activity#GO:0015297;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic anion transmembrane transporter activity#GO:0008509;secondary active transmembrane transporter activity#GO:0015291;monoatomic ion transmembrane transporter activity#GO:0015075;dicarboxylic acid transmembrane transporter activity#GO:0005310;active transmembrane transporter activity#GO:0022804;carboxylic acid transmembrane transporter activity#GO:0046943 chloride transport#GO:0006821;transport#GO:0006810;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;chloride transmembrane transport#GO:1902476;localization#GO:0051179;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698;monoatomic anion transport#GO:0006820;cellular process#GO:0009987;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227 HUMAN|HGNC=1335|UniProtKB=Q9NYF5 Q9NYF5 FAM13B PTHR15904:SF16 FAM13 PROTEIN FAM13B HUMAN|HGNC=35126|UniProtKB=Q7RTU4 Q7RTU4 BHLHA9 PTHR23349:SF10 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST CLASS A BASIC HELIX-LOOP-HELIX PROTEIN 9 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 basic helix-loop-helix transcription factor#PC00055;DNA-binding transcription factor#PC00218 HUMAN|HGNC=19114|UniProtKB=P0DSN6 P0DSN6 TAS2R33 PTHR11394:SF139 TASTE RECEPTOR TYPE 2 TASTE RECEPTOR TYPE 2 MEMBER 19-RELATED molecular transducer activity#GO:0060089;bitter taste receptor activity#GO:0033038;signaling receptor activity#GO:0038023;taste receptor activity#GO:0008527;transmembrane signaling receptor activity#GO:0004888 detection of chemical stimulus involved in sensory perception of bitter taste#GO:0001580;system process#GO:0003008;sensory perception of taste#GO:0050909;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception#GO:0007600;detection of chemical stimulus involved in sensory perception of taste#GO:0050912;nervous system process#GO:0050877;response to chemical#GO:0042221;response to stimulus#GO:0050896;multicellular organismal process#GO:0032501;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;sensory perception of bitter taste#GO:0050913;detection of chemical stimulus#GO:0009593 membrane#GO:0016020;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=14897|UniProtKB=Q96DU7 Q96DU7 ITPKC PTHR12400:SF106 INOSITOL POLYPHOSPHATE KINASE INOSITOL-TRISPHOSPHATE 3-KINASE C transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773 small molecule metabolic process#GO:0044281;biosynthetic process#GO:0009058;phosphorus metabolic process#GO:0006793;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;alcohol biosynthetic process#GO:0046165;organophosphate biosynthetic process#GO:0090407;alcohol metabolic process#GO:0006066;metabolic process#GO:0008152;small molecule biosynthetic process#GO:0044283 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 kinase#PC00137 HUMAN|HGNC=558|UniProtKB=Q9Y6Q5 Q9Y6Q5 AP1M2 PTHR10529:SF234 AP COMPLEX SUBUNIT MU AP-1 COMPLEX SUBUNIT MU-2 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;cargo adaptor activity#GO:0140312 cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;transport#GO:0006810;vacuolar transport#GO:0007034;Golgi to vacuole transport#GO:0006896;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;post-Golgi vesicle-mediated transport#GO:0006892 intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;membrane coat#GO:0030117;AP-1 adaptor complex#GO:0030121;trans-Golgi network transport vesicle#GO:0030140;intracellular membrane-bounded organelle#GO:0043231;vesicle#GO:0031982;membrane protein complex#GO:0098796;organelle membrane#GO:0031090;clathrin-coated vesicle#GO:0030136;Golgi-associated vesicle#GO:0005798;Golgi apparatus#GO:0005794;trans-Golgi network transport vesicle membrane#GO:0012510;transport vesicle membrane#GO:0030658;endomembrane system#GO:0012505;transport vesicle#GO:0030133;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;vesicle membrane#GO:0012506;coated vesicle#GO:0030135;organelle subcompartment#GO:0031984;coated membrane#GO:0048475;intracellular organelle#GO:0043229;coated vesicle membrane#GO:0030662;Golgi-associated vesicle membrane#GO:0030660;clathrin coat#GO:0030118;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular vesicle#GO:0097708;bounding membrane of organelle#GO:0098588;AP-type membrane coat adaptor complex#GO:0030119;clathrin-coated vesicle membrane#GO:0030665;clathrin vesicle coat#GO:0030125;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;vesicle coat#GO:0030120;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991 membrane traffic protein#PC00150 HUMAN|HGNC=2205|UniProtKB=Q9Y5P4 Q9Y5P4 CERT1 PTHR10219:SF105 GLYCOLIPID TRANSFER PROTEIN-RELATED CERAMIDE TRANSFER PROTEIN transporter activity#GO:0005215;phospholipid binding#GO:0005543;lipid binding#GO:0008289;lipid transfer activity#GO:0120013;phospholipid transfer activity#GO:0120014;lipid carrier activity#GO:0005319;ion binding#GO:0043167;molecular carrier activity#GO:0140104;small molecule binding#GO:0036094;anion binding#GO:0043168;binding#GO:0005488 ceramide transport#GO:0035627;cellular component organization#GO:0016043;localization#GO:0051179;cellular localization#GO:0051641;lipid localization#GO:0010876;membrane organization#GO:0061024;lipid transport#GO:0006869;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule localization#GO:0033036;nitrogen compound transport#GO:0071705;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;intermembrane lipid transfer#GO:0120009;transport#GO:0006810;intracellular transport#GO:0046907 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cytosol#GO:0005829;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 transfer/carrier protein#PC00219 HUMAN|HGNC=28784|UniProtKB=Q96MD7 Q96MD7 C9orf85 PTHR22876:SF5 ZGC:101016 CHROMOSOME 9 OPEN READING FRAME 85 HUMAN|HGNC=23803|UniProtKB=Q6IQ32 Q6IQ32 ADNP2 PTHR15740:SF2 NEUROPROTECTIVE PEPTIDE-CONTAINING PROTEIN ACTIVITY-DEPENDENT NEUROPROTECTOR HOMEOBOX PROTEIN 2 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=7660|UniProtKB=P14598 P14598 NCF1 PTHR15706:SF6 SH3 MULTIPLE DOMAIN NEUTROPHIL CYTOSOL FACTOR 1-RELATED enzyme activator activity#GO:0008047;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234 superoxide metabolic process#GO:0006801;cellular process#GO:0009987;reactive oxygen species metabolic process#GO:0072593;metabolic process#GO:0008152 catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;oxidoreductase complex#GO:1990204;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=5733|UniProtKB=P01599 P01599 IGKV1-17 PTHR23267:SF514 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN KAPPA VARIABLE 1-16-RELATED immune system process#GO:0002376;immune response#GO:0006955;response to stimulus#GO:0050896 protein-containing complex#GO:0032991 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=22934|UniProtKB=Q8NAB2 Q8NAB2 KBTBD3 PTHR24412:SF418 KELCH PROTEIN KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 3 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;enzyme-substrate adaptor activity#GO:0140767;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;cullin-RING ubiquitin ligase complex#GO:0031461;catalytic complex#GO:1902494;transferase complex#GO:1990234;ubiquitin ligase complex#GO:0000151;Cul3-RING ubiquitin ligase complex#GO:0031463;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535 scaffold/adaptor protein#PC00226 HUMAN|HGNC=33841|UniProtKB=Q495Y8 Q495Y8 SPDYE2 PTHR31156:SF15 WBSCR19-LIKE PROTEIN SPEEDY PROTEIN E10-RELATED HUMAN|HGNC=10977|UniProtKB=Q9HC58 Q9HC58 SLC24A3 PTHR10846:SF42 SODIUM/POTASSIUM/CALCIUM EXCHANGER SODIUM_POTASSIUM_CALCIUM EXCHANGER 3 potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;calcium channel activity#GO:0005262;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261;sodium ion transmembrane transporter activity#GO:0015081;active transmembrane transporter activity#GO:0022804;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;antiporter activity#GO:0015297;secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873 calcium ion transmembrane transport#GO:0070588;intracellular monoatomic ion homeostasis#GO:0006873;homeostatic process#GO:0042592;metal ion transport#GO:0030001;inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;chemical homeostasis#GO:0048878;transport#GO:0006810;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;cellular homeostasis#GO:0019725;calcium ion transport#GO:0006816;establishment of localization#GO:0051234 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258 HUMAN|HGNC=21314|UniProtKB=Q8WXC6 Q8WXC6 COPS9 PTHR28562:SF3 COP9 SIGNALOSOME COMPLEX SUBUNIT 9 COP9 SIGNALOSOME COMPLEX SUBUNIT 9 HUMAN|HGNC=9108|UniProtKB=Q13794 Q13794 PMAIP1 PTHR14299:SF0 PHORBOL-12-MYRISTATE-13-ACETATE-INDUCED PROTEIN 1 PHORBOL-12-MYRISTATE-13-ACETATE-INDUCED PROTEIN 1 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739 p53 pathway#P00059>NOXA#G01572 HUMAN|HGNC=1573|UniProtKB=O00522 O00522 KRIT1 PTHR13283:SF11 KREV INTERACTION TRAPPED 1-RELATED KREV INTERACTION TRAPPED PROTEIN 1 protein binding#GO:0005515;microtubule binding#GO:0008017;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631 regulation of vasculature development#GO:1901342;anterior/posterior pattern specification#GO:0009952;developmental process#GO:0032502;regulation of anatomical structure morphogenesis#GO:0022603;anterior/posterior axis specification#GO:0009948;negative regulation of angiogenesis#GO:0016525;multicellular organism development#GO:0007275;cellular homeostasis#GO:0019725;cell redox homeostasis#GO:0045454;multicellular organismal process#GO:0032501;regulation of establishment or maintenance of cell polarity#GO:0032878;regionalization#GO:0003002;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;pattern specification process#GO:0007389;anatomical structure development#GO:0048856;regulation of angiogenesis#GO:0045765;negative regulation of biological process#GO:0048519;negative regulation of multicellular organismal process#GO:0051241;regulation of multicellular organismal development#GO:2000026;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;homeostatic process#GO:0042592;regulation of developmental process#GO:0050793 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HUMAN|HGNC=19974|UniProtKB=Q8IUC4 Q8IUC4 RHPN2 PTHR23031:SF5 RHOPHILIN RHOPHILIN-2-RELATED negative regulation of cytoskeleton organization#GO:0051494;negative regulation of organelle organization#GO:0010639;negative regulation of cellular component organization#GO:0051129;regulation of actin filament bundle assembly#GO:0032231;negative regulation of biological process#GO:0048519;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of supramolecular fiber organization#GO:1902903;regulation of cellular process#GO:0050794;negative regulation of supramolecular fiber organization#GO:1902904;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component biogenesis#GO:0044087;regulation of stress fiber assembly#GO:0051492;regulation of actin filament-based process#GO:0032970;negative regulation of cellular process#GO:0048523;regulation of actin filament organization#GO:0110053;regulation of actin cytoskeleton organization#GO:0032956;biological regulation#GO:0065007 scaffold/adaptor protein#PC00226 HUMAN|HGNC=17616|UniProtKB=Q8NFM7 Q8NFM7 IL17RD PTHR15583:SF14 INTERLEUKIN-17 RECEPTOR INTERLEUKIN-17 RECEPTOR D molecular transducer activity#GO:0060089;immune receptor activity#GO:0140375;signaling receptor activity#GO:0038023;cytokine receptor activity#GO:0004896;transmembrane signaling receptor activity#GO:0004888 response to cytokine#GO:0034097;response to stimulus#GO:0050896;response to chemical#GO:0042221;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;response to peptide#GO:1901652;cytokine-mediated signaling pathway#GO:0019221;cell surface receptor signaling pathway#GO:0007166 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=1051|UniProtKB=Q13323 Q13323 BIK PTHR15018:SF1 BCL-2-INTERACTING KILLER BCL-2-INTERACTING KILLER biological regulation#GO:0065007;positive regulation of programmed cell death#GO:0043068;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of programmed cell death#GO:0043067;positive regulation of apoptotic process#GO:0043065;regulation of apoptotic process#GO:0042981 organelle envelope#GO:0031967;mitochondrion#GO:0005739;mitochondrial envelope#GO:0005740;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 Apoptosis signaling pathway#P00006>Blk#P00290;Apoptosis signaling pathway#P00006>Bik#P00258 HUMAN|HGNC=24969|UniProtKB=Q8WTW4 Q8WTW4 NPRL2 PTHR12991:SF10 NITROGEN PERMEASE REGULATOR 2/TUMOR SUPPRESSOR CANDIDATE 4 GATOR1 COMPLEX PROTEIN NPRL2 molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;enzyme activator activity#GO:0008047 regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;negative regulation of biological process#GO:0048519;response to starvation#GO:0042594;regulation of cell communication#GO:0010646;negative regulation of TOR signaling#GO:0032007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cellular response to stress#GO:0033554;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;cellular process#GO:0009987;regulation of TOR signaling#GO:0032006;response to nutrient levels#GO:0031667;response to stress#GO:0006950;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of signal transduction#GO:0009968;cellular response to amino acid starvation#GO:0034198;negative regulation of response to stimulus#GO:0048585;negative regulation of TORC1 signaling#GO:1904262;cellular response to nutrient levels#GO:0031669;regulation of response to stimulus#GO:0048583;cellular response to starvation#GO:0009267;negative regulation of cellular process#GO:0048523;regulation of TORC1 signaling#GO:1903432 vacuole#GO:0005773;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;Seh1-associated complex#GO:0035859;vacuolar membrane#GO:0005774;intracellular organelle#GO:0043229 G-protein modulator#PC00022;GTPase-activating protein#PC00257 HUMAN|HGNC=20882|UniProtKB=Q9NWT1 Q9NWT1 PAK1IP1 PTHR44675:SF1 PAK1 INTERACTING PROTEIN 1 P21-ACTIVATED PROTEIN KINASE-INTERACTING PROTEIN 1 enzyme inhibitor activity#GO:0004857;kinase inhibitor activity#GO:0019210;protein kinase regulator activity#GO:0019887;kinase regulator activity#GO:0019207;protein kinase inhibitor activity#GO:0004860;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678 ribosome biogenesis#GO:0042254;ribosomal large subunit biogenesis#GO:0042273;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;maturation of LSU-rRNA#GO:0000470;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;RNA processing#GO:0006396;biosynthetic process#GO:0009058 nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228 HUMAN|HGNC=25200|UniProtKB=Q8N365 Q8N365 CIART PTHR35441:SF1 CIRCADIAN-ASSOCIATED TRANSCRIPTIONAL REPRESSOR CIRCADIAN-ASSOCIATED TRANSCRIPTIONAL REPRESSOR sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;circadian rhythm#GO:0007623;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;rhythmic process#GO:0048511;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of metabolic process#GO:0009892;circadian regulation of gene expression#GO:0032922;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218 HUMAN|HGNC=24986|UniProtKB=Q7Z6W7 Q7Z6W7 DNAJB7 PTHR43948:SF4 DNAJ HOMOLOG SUBFAMILY B DNAJ HOMOLOG SUBFAMILY B MEMBER 7 protein binding#GO:0005515;binding#GO:0005488;protein-folding chaperone binding#GO:0051087 metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;protein folding#GO:0006457;gene expression#GO:0010467;protein maturation#GO:0051604 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 chaperone#PC00072 HUMAN|HGNC=18588|UniProtKB=Q92527 Q92527 ANKRD7 PTHR24147:SF62 ANKYRIN REPEAT DOMAIN 36-RELATED ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 7 HUMAN|HGNC=18111|UniProtKB=Q8IVM0 Q8IVM0 CCDC50 PTHR22115:SF1 C3ORF6 PROTEIN-RELATED COILED-COIL DOMAIN-CONTAINING PROTEIN 50 binding#GO:0005488;ubiquitin-like protein ligase binding#GO:0044389;enzyme binding#GO:0019899;protein binding#GO:0005515;ubiquitin protein ligase binding#GO:0031625 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=10003|UniProtKB=P49802 P49802 RGS7 PTHR45746:SF7 LP21163P REGULATOR OF G PROTEIN SIGNALING 7 enzyme activator activity#GO:0008047;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052 intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;cell projection#GO:0042995;membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>RGS#P00731;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>RGS#P00704 HUMAN|HGNC=18229|UniProtKB=Q96D21 Q96D21 RASD2 PTHR46149:SF1 MIP08469P GTP-BINDING PROTEIN RHES binding#GO:0005488;protein binding#GO:0005515 signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154 HUMAN|HGNC=34440|UniProtKB=A6NLE4 A6NLE4 SMIM23 PTHR37865:SF1 SMALL INTEGRAL MEMBRANE PROTEIN 23 SMALL INTEGRAL MEMBRANE PROTEIN 23 HUMAN|HGNC=21488|UniProtKB=Q5EE01 Q5EE01 CENPW PTHR34832:SF1 CENTROMERE PROTEIN W CENTROMERE PROTEIN W kinetochore organization#GO:0051383;kinetochore assembly#GO:0051382;organelle assembly#GO:0070925;mitotic cell cycle#GO:0000278;cell cycle process#GO:0022402;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;cell cycle#GO:0007049;protein-containing complex organization#GO:0043933;chromosome organization#GO:0051276;cellular component organization or biogenesis#GO:0071840;chromosome segregation#GO:0007059;cellular component assembly#GO:0022607;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687;condensed chromosome#GO:0000793;chromosome, centromeric region#GO:0000775;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232;condensed chromosome, centromeric region#GO:0000779;chromosome#GO:0005694;kinetochore#GO:0000776 HUMAN|HGNC=3515|UniProtKB=Q92935 Q92935 EXTL1 PTHR11062:SF8 EXOSTOSIN HEPARAN SULFATE GLYCOSYLTRANSFERASE -RELATED EXOSTOSIN-LIKE 1 hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;glucuronosyltransferase activity#GO:0015020;catalytic activity#GO:0003824;acetylglucosaminyltransferase activity#GO:0008375;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 transferase#PC00220;glycosyltransferase#PC00111 HUMAN|HGNC=15104|UniProtKB=Q8NGT0 Q8NGT0 OR13C9 PTHR26453:SF23 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 13C9 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 detection of chemical stimulus#GO:0009593;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;response to stimulus#GO:0050896;response to chemical#GO:0042221;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;sensory perception#GO:0007600;nervous system process#GO:0050877;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=4703|UniProtKB=P06028 P06028 GYPB PTHR13813:SF2 GLYCOPHORIN GLYCOPHORIN-B cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HUMAN|HGNC=21726|UniProtKB=Q96PE2 Q96PE2 ARHGEF17 PTHR12877:SF15 RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 17 GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 guanyl-nucleotide exchange factor#PC00113;protein-binding activity modulator#PC00095;G-protein modulator#PC00022 HUMAN|HGNC=14148|UniProtKB=Q96S16 Q96S16 JMJD8 PTHR12480:SF35 ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD JMJC DOMAIN-CONTAINING PROTEIN 8 protein modifying enzyme#PC00260 HUMAN|HGNC=17327|UniProtKB=Q9BTA9 Q9BTA9 WAC PTHR15911:SF6 WW DOMAIN-CONTAINING ADAPTER PROTEIN WITH COILED-COIL WW DOMAIN-CONTAINING ADAPTER PROTEIN WITH COILED-COIL binding#GO:0005488;enzyme binding#GO:0019899;chromatin binding#GO:0003682;RNA polymerase binding#GO:0070063;RNA polymerase II complex binding#GO:0000993;protein binding#GO:0005515;RNA polymerase core enzyme binding#GO:0043175 positive regulation of TORC1 signaling#GO:1904263;regulation of metabolic process#GO:0019222;regulation of TOR signaling#GO:0032006;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;regulation of catabolic process#GO:0009894;regulation of TORC1 signaling#GO:1903432;regulation of autophagy#GO:0010506;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;positive regulation of TOR signaling#GO:0032008 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=30216|UniProtKB=O43633 O43633 CHMP2A PTHR10476:SF4 CHARGED MULTIVESICULAR BODY PROTEIN CHARGED MULTIVESICULAR BODY PROTEIN 2A macromolecule localization#GO:0033036;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;multivesicular body sorting pathway#GO:0071985;endosome transport via multivesicular body sorting pathway#GO:0032509;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;vacuolar transport#GO:0007034;transport#GO:0006810;establishment of localization#GO:0051234;endosomal transport#GO:0016197;intracellular protein localization#GO:0008104;late endosome to vacuole transport#GO:0045324;localization#GO:0051179;cellular localization#GO:0051641;protein transport#GO:0015031 organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;late endosome#GO:0005770;vesicle membrane#GO:0012506;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768;endosome membrane#GO:0010008;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708 membrane traffic protein#PC00150 HUMAN|HGNC=33882|UniProtKB=Q9BT40 Q9BT40 INPP5K PTHR11200:SF117 INOSITOL 5-PHOSPHATASE INOSITOL POLYPHOSPHATE 5-PHOSPHATASE K catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578 regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051896;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of cell communication#GO:0010646;negative regulation of metabolic process#GO:0009892;regulation of carbohydrate biosynthetic process#GO:0043255;regulation of carbohydrate metabolic process#GO:0006109;negative regulation of cellular process#GO:0048523;regulation of glycogen biosynthetic process#GO:0005979;regulation of response to stimulus#GO:0048583;regulation of biosynthetic process#GO:0009889;regulation of polysaccharide biosynthetic process#GO:0032885;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of response to stimulus#GO:0048585;negative regulation of signal transduction#GO:0009968;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of polysaccharide metabolic process#GO:0032881;negative regulation of biosynthetic process#GO:0009890 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;ruffle#GO:0001726;endoplasmic reticulum#GO:0005783;endomembrane system#GO:0012505;plasma membrane#GO:0005886;cytoplasm#GO:0005737;cell leading edge#GO:0031252;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944 phosphatase#PC00181;hydrolase#PC00121 HUMAN|HGNC=15488|UniProtKB=Q9NPF7 Q9NPF7 IL23A PTHR15947:SF0 SGRF INTERLEUKIN-23 SUBUNIT ALPHA intercellular signal molecule#PC00207;interleukin superfamily#PC00128;cytokine#PC00083 Interleukin signaling pathway#P00036>Receptor subunit alpha#P00992 HUMAN|HGNC=20472|UniProtKB=O15116 O15116 LSM1 PTHR15588:SF8 LSM1 U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM1 nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;RNA binding#GO:0003723 regulation of nucleobase-containing compound metabolic process#GO:0019219;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;nucleobase-containing compound catabolic process#GO:0034655;nucleic acid catabolic process#GO:0141188;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;positive regulation of catabolic process#GO:0009896;nuclear-transcribed mRNA catabolic process#GO:0000956;macromolecule metabolic process#GO:0043170;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;positive regulation of RNA metabolic process#GO:0051254;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;positive regulation of mRNA catabolic process#GO:0061014;RNA decapping#GO:0110154;regulation of RNA metabolic process#GO:0051252;regulation of RNA stability#GO:0043487;positive regulation of macromolecule metabolic process#GO:0010604;RNA destabilization#GO:0050779;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;regulation of mRNA metabolic process#GO:1903311;positive regulation of mRNA metabolic process#GO:1903313;mRNA destabilization#GO:0061157;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;regulation of mRNA stability#GO:0043488;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;negative regulation of gene expression#GO:0010629;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;RNA metabolic process#GO:0016070;positive regulation of metabolic process#GO:0009893;regulation of biological quality#GO:0065008;RNA catabolic process#GO:0006401 supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;P-body#GO:0000932;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;Sm-like protein family complex#GO:0120114;intracellular anatomical structure#GO:0005622 RNA processing factor#PC00147;RNA splicing factor#PC00148 HUMAN|HGNC=25002|UniProtKB=Q9H0I3 Q9H0I3 CFAP263 PTHR15654:SF2 COILED-COIL DOMAIN-CONTAINING PROTEIN 113-RELATED CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 263 cellular component assembly#GO:0022607;cell projection organization#GO:0030030;plasma membrane bounded cell projection organization#GO:0120036;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782;plasma membrane bounded cell projection assembly#GO:0120031;organelle assembly#GO:0070925 axoneme#GO:0005930;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cilium#GO:0005929;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;membraneless organelle#GO:0043228;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;ciliary basal body#GO:0036064;ciliary plasm#GO:0097014;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630 HUMAN|HGNC=20598|UniProtKB=Q86WA8 Q86WA8 LONP2 PTHR10046:SF24 ATP DEPENDENT LON PROTEASE FAMILY MEMBER LON PROTEASE HOMOLOG 2, PEROXISOMAL catalytic activity#GO:0003824;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096 protein targeting#GO:0006605;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;localization#GO:0051179;proteolysis#GO:0006508;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein processing#GO:0016485;establishment of protein localization#GO:0045184;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;microbody#GO:0042579;peroxisome#GO:0005777;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 serine protease#PC00203;protease#PC00190 HUMAN|HGNC=29373|UniProtKB=Q9C099 Q9C099 LRRCC1 PTHR15454:SF34 NISCHARIN RELATED LEUCINE-RICH REPEAT AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;centrosome#GO:0005813;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630 scaffold/adaptor protein#PC00226 HUMAN|HGNC=6024|UniProtKB=P16871 P16871 IL7R PTHR23037:SF27 CYTOKINE RECEPTOR INTERLEUKIN-7 RECEPTOR SUBUNIT ALPHA immune receptor activity#GO:0140375;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;cytokine receptor activity#GO:0004896;transmembrane signaling receptor activity#GO:0004888 positive regulation of receptor signaling pathway via JAK-STAT#GO:0046427;cytokine-mediated signaling pathway#GO:0019221;anatomical structure development#GO:0048856;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;regulation of receptor signaling pathway via STAT#GO:1904892;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of receptor signaling pathway via JAK-STAT#GO:0046425;regulation of response to stimulus#GO:0048583;developmental process#GO:0032502;cellular developmental process#GO:0048869;positive regulation of cellular process#GO:0048522;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;hemopoiesis#GO:0030097;positive regulation of response to stimulus#GO:0048584;regulation of signaling#GO:0023051;response to peptide#GO:1901652;positive regulation of signaling#GO:0023056;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;cell development#GO:0048468;signaling#GO:0023052;response to stimulus#GO:0050896;cell differentiation#GO:0030154;cell surface receptor signaling pathway#GO:0007166;interleukin-7-mediated signaling pathway#GO:0038111;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;response to cytokine#GO:0034097;response to chemical#GO:0042221 cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020;plasma membrane#GO:0005886;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552 transmembrane signal receptor#PC00197 HUMAN|HGNC=5926|UniProtKB=A0A0A0MRZ9 A0A0A0MRZ9 IGLV5-52 PTHR23267:SF360 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN LAMBDA VARIABLE 5-52 immune response#GO:0006955;immune system process#GO:0002376;response to stimulus#GO:0050896 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=25462|UniProtKB=Q9BZ67 Q9BZ67 FRMD8 PTHR13283:SF13 KREV INTERACTION TRAPPED 1-RELATED FERM DOMAIN-CONTAINING PROTEIN 8 regulation of Wnt signaling pathway#GO:0030111;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of cell communication#GO:0010648;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;negative regulation of canonical Wnt signaling pathway#GO:0090090;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of signal transduction#GO:0009968;negative regulation of Wnt signaling pathway#GO:0030178;negative regulation of response to stimulus#GO:0048585;regulation of canonical Wnt signaling pathway#GO:0060828;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HUMAN|HGNC=6088|UniProtKB=Q9Y5Q6 Q9Y5Q6 INSL5 PTHR20968:SF2 ILGF DOMAIN-CONTAINING PROTEIN INSULIN-LIKE PEPTIDE INSL5 signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;G protein-coupled receptor binding#GO:0001664;protein binding#GO:0005515;molecular function activator activity#GO:0140677;binding#GO:0005488;signaling receptor binding#GO:0005102 regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;positive regulation of signal transduction#GO:0009967;positive regulation of multicellular organismal process#GO:0051240;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of cell communication#GO:0010646;regulation of response to stimulus#GO:0048583;regulation of G protein-coupled receptor signaling pathway#GO:0008277;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of response to stimulus#GO:0048584;regulation of multicellular organismal process#GO:0051239;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007 HUMAN|HGNC=15902|UniProtKB=Q8IXH8 Q8IXH8 CDH26 PTHR24027:SF78 CADHERIN-23 CADHERIN-LIKE PROTEIN 26 beta-catenin binding#GO:0008013;protein binding#GO:0005515;cell adhesion molecule binding#GO:0050839;binding#GO:0005488 cell migration#GO:0016477;cell motility#GO:0048870;cell-cell adhesion#GO:0098609;cellular process#GO:0009987;cell adhesion#GO:0007155 extrinsic component of plasma membrane#GO:0019897;extrinsic component of membrane#GO:0019898;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 cell adhesion molecule#PC00069;cadherin#PC00057 HUMAN|HGNC=20071|UniProtKB=Q53GS9 Q53GS9 USP39 PTHR21646:SF16 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 39 catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;cysteine-type deubiquitinase activity#GO:0004843;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787 nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;protein-RNA complex organization#GO:0071826;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;cellular component biogenesis#GO:0044085;mRNA processing#GO:0006397;cellular process#GO:0009987;regulation of protein stability#GO:0031647;gene expression#GO:0010467;cellular component assembly#GO:0022607;RNA processing#GO:0006396;spliceosomal complex assembly#GO:0000245;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;regulation of biological quality#GO:0065008;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;mRNA splicing, via spliceosome#GO:0000398;ribonucleoprotein complex biogenesis#GO:0022613;mRNA metabolic process#GO:0016071;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA splicing, via transesterification reactions#GO:0000375;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;protein-RNA complex assembly#GO:0022618;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 cysteine protease#PC00081 HUMAN|HGNC=15808|UniProtKB=Q9H116 Q9H116 GZF1 PTHR24384:SF191 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED GDNF-INDUCIBLE ZINC FINGER PROTEIN 1 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488 regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218 HUMAN|HGNC=4792|UniProtKB=Q99525 Q99525 H4C7 PTHR10484:SF162 HISTONE H4 HISTONE H4-LIKE PROTEIN TYPE G structural molecule activity#GO:0005198 protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;protein-DNA complex assembly#GO:0065004;chromatin organization#GO:0006325;chromatin remodeling#GO:0006338;cellular component assembly#GO:0022607;protein-containing complex organization#GO:0043933;nucleosome organization#GO:0034728;cellular component organization or biogenesis#GO:0071840;protein-DNA complex organization#GO:0071824 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=10070|UniProtKB=Q9UBF6 Q9UBF6 RNF7 PTHR11210:SF60 RING BOX RING-BOX PROTEIN 2 aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;protein binding#GO:0005515;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;binding#GO:0005488;acyltransferase activity#GO:0016746 catabolic process#GO:0009056;protein modification process#GO:0036211;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;protein modification by small protein conjugation#GO:0032446;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein modification by small protein conjugation or removal#GO:0070647;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152 nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle#GO:0043229;Cul5-RING ubiquitin ligase complex#GO:0031466;ubiquitin ligase complex#GO:0000151;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=19291|UniProtKB=Q7Z407 Q7Z407 CSMD3 PTHR45656:SF9 PROTEIN CBR-CLEC-78 CUB AND SUSHI DOMAIN-CONTAINING PROTEIN 3 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HUMAN|HGNC=2451|UniProtKB=P48729 P48729 CSNK1A1 PTHR11909:SF84 CASEIN KINASE-RELATED CASEIN KINASE I ISOFORM ALPHA catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of Wnt signaling pathway#GO:0030111;regulation of cell communication#GO:0010646;negative regulation of signaling#GO:0023057;negative regulation of canonical Wnt signaling pathway#GO:0090090;regulation of signaling#GO:0023051;cell communication#GO:0007154;negative regulation of cell communication#GO:0010648;regulation of canonical Wnt signaling pathway#GO:0060828;signal transduction#GO:0007165;cellular process#GO:0009987;negative regulation of Wnt signaling pathway#GO:0030178;negative regulation of response to stimulus#GO:0048585;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of signal transduction#GO:0009968;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 non-receptor serine/threonine protein kinase#PC00167 Wnt signaling pathway#P00057>Casein Kinase 1#P01460;CCKR signaling map#P06959>CK1#P07049;Hedgehog signaling pathway#P00025>Casein kinase I#P00681;Parkinson disease#P00049>Casein kinase I#P01242 HUMAN|HGNC=21076|UniProtKB=Q9Y6G1 Q9Y6G1 TMEM14A PTHR12668:SF11 TRANSMEMBRANE PROTEIN 14, 15 TRANSMEMBRANE PROTEIN 14A organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle envelope#GO:0031967;membrane#GO:0016020;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;intracellular organelle#GO:0043229 HUMAN|HGNC=3046|UniProtKB=P57054 P57054 PIGP PTHR46346:SF1 PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P glycerolipid metabolic process#GO:0046486;liposaccharide metabolic process#GO:1903509;GPI anchored protein biosynthesis#GO:0180046;glycolipid metabolic process#GO:0006664;phospholipid biosynthetic process#GO:0008654;phospholipid metabolic process#GO:0006644;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;glycolipid biosynthetic process#GO:0009247;protein metabolic process#GO:0019538;organophosphate biosynthetic process#GO:0090407;GPI anchor biosynthetic process#GO:0006506;glycerophospholipid metabolic process#GO:0006650;lipid biosynthetic process#GO:0008610;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;organophosphate metabolic process#GO:0019637;carbohydrate derivative metabolic process#GO:1901135;glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;metabolic process#GO:0008152;GPI anchor metabolic process#GO:0006505;glycerophospholipid biosynthetic process#GO:0046474;lipid metabolic process#GO:0006629 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 transferase#PC00220 HUMAN|HGNC=28868|UniProtKB=O00425 O00425 IGF2BP3 PTHR10288:SF158 KH DOMAIN CONTAINING RNA BINDING PROTEIN INSULIN-LIKE GROWTH FACTOR 2 MRNA-BINDING PROTEIN 3 binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723;mRNA 3'-UTR binding#GO:0003730 animal gross anatomical part developmental process#GO:0160108;regulation of biological quality#GO:0065008;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;RNA stabilization#GO:0043489;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;negative regulation of metabolic process#GO:0009892;regulation of mRNA stability#GO:0043488;negative regulation of RNA metabolic process#GO:0051253;multicellular organism development#GO:0007275;regulation of mRNA metabolic process#GO:1903311;positive regulation of biological process#GO:0048518;mRNA stabilization#GO:0048255;nervous system development#GO:0007399;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA stability#GO:0043487;negative regulation of catabolic process#GO:0009895;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;anatomical structure development#GO:0048856;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;developmental process#GO:0032502;negative regulation of RNA catabolic process#GO:1902369;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;positive regulation of gene expression#GO:0010628;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytoplasmic stress granule#GO:0010494;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;supramolecular complex#GO:0099080;organelle#GO:0043226;ribonucleoprotein granule#GO:0035770;nucleus#GO:0005634;cytosol#GO:0005829 RNA metabolism protein#PC00031 HUMAN|HGNC=1100|UniProtKB=P38398 P38398 BRCA1 PTHR13763:SF11 BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN BRCA1 BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN ubiquitin-like protein transferase activity#GO:0019787;binding#GO:0005488;nucleic acid binding#GO:0003676;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;DNA binding#GO:0003677;damaged DNA binding#GO:0003684;transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 recombinational repair#GO:0000725;intracellular signal transduction#GO:0035556;regulation of G2/M transition of mitotic cell cycle#GO:0010389;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of cell cycle phase transition#GO:1901987;mitotic cell cycle checkpoint signaling#GO:0007093;cell cycle#GO:0007049;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mitotic cell cycle#GO:0000278;regulation of cellular process#GO:0050794;DNA damage response#GO:0006974;negative regulation of cell cycle process#GO:0010948;DNA repair#GO:0006281;negative regulation of cellular process#GO:0048523;mitotic cell cycle process#GO:1903047;macromolecule metabolic process#GO:0043170;mitotic G2/M transition checkpoint#GO:0044818;regulation of mitotic cell cycle#GO:0007346;regulation of cell cycle G2/M phase transition#GO:1902749;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;cellular response to stress#GO:0033554;negative regulation of mitotic cell cycle#GO:0045930;regulation of mitotic cell cycle phase transition#GO:1901990;regulation of biological process#GO:0050789;cell cycle process#GO:0022402;double-strand break repair via homologous recombination#GO:0000724;negative regulation of biological process#GO:0048519;negative regulation of cell cycle phase transition#GO:1901988;regulation of cell cycle#GO:0051726;signaling#GO:0023052;response to stimulus#GO:0050896;DNA recombination#GO:0006310;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;double-strand break repair#GO:0006302;negative regulation of cell cycle G2/M phase transition#GO:1902750;negative regulation of cell cycle#GO:0045786;signal transduction#GO:0007165;cellular process#GO:0009987;response to stress#GO:0006950;regulation of cell cycle process#GO:0010564;cell cycle checkpoint signaling#GO:0000075;negative regulation of mitotic cell cycle phase transition#GO:1901991;negative regulation of G2/M transition of mitotic cell cycle#GO:0010972 transferase complex#GO:1990234;condensed chromosome#GO:0000793;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;condensed nuclear chromosome#GO:0000794;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;DNA repair complex#GO:1990391;membrane-enclosed lumen#GO:0031974;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ubiquitin ligase complex#GO:0000151;chromosome#GO:0005694;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nuclear ubiquitin ligase complex#GO:0000152;organelle#GO:0043226 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=25822|UniProtKB=Q9H8K7 Q9H8K7 PAAT PTHR14787:SF3 C10ORF188 FAMILY MEMBER ATPASE PAAT catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP-dependent activity#GO:0140657;hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=5716|UniProtKB=P01834 P01834 IGKC PTHR23266:SF367 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN KAPPA CONSTANT binding#GO:0005488;antigen binding#GO:0003823 immune effector process#GO:0002252;immune system process#GO:0002376;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;immune response#GO:0006955;adaptive immune response#GO:0002250;response to stimulus#GO:0050896 protein-containing complex#GO:0032991 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=14134|UniProtKB=Q9NRR2 Q9NRR2 TPSG1 PTHR24256:SF487 TRYPTASE-RELATED TRYPTASE GAMMA serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;serine-type peptidase activity#GO:0008236 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;proteolysis#GO:0006508;primary metabolic process#GO:0044238;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 serine protease#PC00203 HUMAN|HGNC=7983|UniProtKB=Q13285 Q13285 NR5A1 PTHR24086:SF24 NUCLEAR RECEPTOR SUBFAMILY 5 GROUP A STEROIDOGENIC FACTOR 1 RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 signaling#GO:0023052;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;cellular response to hormone stimulus#GO:0032870;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to endogenous stimulus#GO:0009719;regulation of RNA metabolic process#GO:0051252;cell communication#GO:0007154;regulation of DNA-templated transcription#GO:0006355;hormone-mediated signaling pathway#GO:0009755;anatomical structure development#GO:0048856;cellular response to chemical stimulus#GO:0070887;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;response to chemical#GO:0042221;tissue development#GO:0009888;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;response to hormone#GO:0009725;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502 nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218;C4 zinc finger nuclear receptor#PC00169;zinc finger transcription factor#PC00244 Gonadotropin-releasing hormone receptor pathway#P06664>SF1#P06848 HUMAN|HGNC=29300|UniProtKB=Q63ZY3 Q63ZY3 KANK2 PTHR24168:SF0 KN MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING KN MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 2 negative regulation of cytoskeleton organization#GO:0051494;regulation of DNA-templated transcription#GO:0006355;regulation of supramolecular fiber organization#GO:1902903;negative regulation of cellular component organization#GO:0051129;negative regulation of supramolecular fiber organization#GO:1902904;regulation of protein polymerization#GO:0032271;regulation of cytoskeleton organization#GO:0051493;negative regulation of cell cycle process#GO:0010948;regulation of actin filament-based process#GO:0032970;regulation of gene expression#GO:0010468;regulation of mitotic cell cycle#GO:0007346;regulation of actin filament organization#GO:0110053;regulation of macromolecule biosynthetic process#GO:0010556;regulation of signal transduction#GO:0009966;regulation of actin polymerization or depolymerization#GO:0008064;regulation of RNA biosynthetic process#GO:2001141;regulation of actin filament polymerization#GO:0030833;regulation of intracellular signal transduction#GO:1902531;negative regulation of mitotic cell cycle#GO:0045930;regulation of mitotic cell cycle phase transition#GO:1901990;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of DNA-templated transcription#GO:0045892;regulation of cellular component size#GO:0032535;cellular component organization#GO:0016043;regulation of protein-containing complex assembly#GO:0043254;negative regulation of metabolic process#GO:0009892;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cell cycle#GO:0045786;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cell cycle process#GO:0010564;regulation of actin cytoskeleton organization#GO:0032956;negative regulation of protein polymerization#GO:0032272;negative regulation of protein-containing complex assembly#GO:0031333;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;regulation of cell population proliferation#GO:0042127;regulation of cell cycle phase transition#GO:1901987;negative regulation of organelle organization#GO:0010639;regulation of cell cycle G1/S phase transition#GO:1902806;regulation of cell communication#GO:0010646;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;negative regulation of cell population proliferation#GO:0008285;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of response to stimulus#GO:0048585;regulation of G1/S transition of mitotic cell cycle#GO:2000045;regulation of actin filament length#GO:0030832;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of biological quality#GO:0065008;negative regulation of cell communication#GO:0010648;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;negative regulation of biological process#GO:0048519;negative regulation of cell cycle phase transition#GO:1901988;regulation of cell cycle#GO:0051726;negative regulation of actin filament polymerization#GO:0030837;regulation of cellular component biogenesis#GO:0044087;regulation of cellular component organization#GO:0051128;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of RNA metabolic process#GO:0051253;regulation of anatomical structure size#GO:0090066;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;negative regulation of signal transduction#GO:0009968;negative regulation of mitotic cell cycle phase transition#GO:1901991 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226 non-motor actin binding protein#PC00165 HUMAN|HGNC=3009|UniProtKB=P27487 P27487 DPP4 PTHR11731:SF128 PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED DIPEPTIDYL PEPTIDASE 4 hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;exopeptidase activity#GO:0008238;peptidase activity#GO:0008233;catalytic activity#GO:0003824 cellular process#GO:0009987;metabolic process#GO:0008152;proteolysis#GO:0006508;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 protease#PC00190;serine protease#PC00203 HUMAN|HGNC=3638|UniProtKB=P10109 P10109 FDX1 PTHR23426:SF26 FERREDOXIN/ADRENODOXIN ADRENODOXIN, MITOCHONDRIAL generation of precursor metabolites and energy#GO:0006091;cellular process#GO:0009987;metabolic process#GO:0008152;electron transport chain#GO:0022900 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 oxidoreductase#PC00176 Vitamin D metabolism and pathway#P04396>FDX#P04607 HUMAN|HGNC=18417|UniProtKB=O75409 O75409 H2AP PTHR23430:SF63 HISTONE H2A HUNTINGTIN-INTERACTING PROTEIN M structural molecule activity#GO:0005198 negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;negative regulation of gene expression, epigenetic#GO:0045814;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;epigenetic regulation of gene expression#GO:0040029;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;heterochromatin organization#GO:0070828;chromatin organization#GO:0006325;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;cellular component assembly#GO:0022607;regulation of biological process#GO:0050789;heterochromatin formation#GO:0031507;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255 membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;protein-DNA complex#GO:0032993;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleosome#GO:0000786;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;chromatin#GO:0000785;nucleus#GO:0005634 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=40912|UniProtKB=P0DJH9 P0DJH9 RD3L PTHR28489:SF3 RENTINAL DEGENERATION 3-LIKE PROTEIN RD3-LIKE HUMAN|HGNC=17971|UniProtKB=Q9P0P8 Q9P0P8 MTRES1 PTHR13633:SF3 MITOCHONDRIAL TRANSCRIPTION RESCUE FACTOR 1 MITOCHONDRIAL TRANSCRIPTION RESCUE FACTOR 1 binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HUMAN|HGNC=15660|UniProtKB=A8MWL7 A8MWL7 TMEM14DP PTHR12668:SF56 TRANSMEMBRANE PROTEIN 14, 15 TRANSMEMBRANE PROTEIN 14DP cellular process#GO:0009987;pigment metabolic process#GO:0042440;heme biosynthetic process#GO:0006783;biosynthetic process#GO:0009058;heme metabolic process#GO:0042168;tetrapyrrole biosynthetic process#GO:0033014;porphyrin-containing compound metabolic process#GO:0006778;pigment biosynthetic process#GO:0046148;metabolic process#GO:0008152;tetrapyrrole metabolic process#GO:0033013;porphyrin-containing compound biosynthetic process#GO:0006779 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;organelle envelope#GO:0031967;mitochondrial envelope#GO:0005740;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HUMAN|HGNC=3961|UniProtKB=Q9NQT6 Q9NQT6 FSCN3 PTHR10551:SF1 FASCIN FASCIN-3 protein-containing complex binding#GO:0044877;protein binding#GO:0005515;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;actin filament binding#GO:0051015;binding#GO:0005488 cellular component organization or biogenesis#GO:0071840;actin filament organization#GO:0007015;cellular component assembly#GO:0022607;cell migration#GO:0016477;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;supramolecular fiber organization#GO:0097435;establishment or maintenance of cell polarity#GO:0007163;actin filament-based process#GO:0030029;cell motility#GO:0048870;actin cytoskeleton organization#GO:0030036;cellular component organization#GO:0016043;actin filament bundle assembly#GO:0051017;actin filament bundle organization#GO:0061572 membraneless organelle#GO:0043228;ruffle#GO:0001726;cytoskeleton#GO:0005856;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;lamellipodium#GO:0030027;plasma membrane region#GO:0098590;cell periphery#GO:0071944;neuron projection#GO:0043005;membrane#GO:0016020;cell leading edge#GO:0031252;intracellular anatomical structure#GO:0005622;site of polarized growth#GO:0030427;cell projection membrane#GO:0031253;growth cone#GO:0030426;intracellular organelle#GO:0043229;axon#GO:0030424;filopodium#GO:0030175;distal axon#GO:0150034;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;microvillus#GO:0005902;actin-based cell projection#GO:0098858;actin cytoskeleton#GO:0015629 non-motor actin binding protein#PC00165 HUMAN|HGNC=10490|UniProtKB=Q99584 Q99584 S100A13 PTHR11639:SF57 S100 CALCIUM-BINDING PROTEIN PROTEIN S100-A13 ion binding#GO:0043167;signaling receptor binding#GO:0005102;binding#GO:0005488;small molecule binding#GO:0036094;calcium ion binding#GO:0005509;protein binding#GO:0005515;metal ion binding#GO:0046872;cation binding#GO:0043169 positive regulation of canonical NF-kappaB signal transduction#GO:0043123;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;regulation of canonical NF-kappaB signal transduction#GO:0043122;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;regulation of cell communication#GO:0010646;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165;perinuclear region of cytoplasm#GO:0048471;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 calmodulin-related#PC00061;calcium-binding protein#PC00060 HUMAN|HGNC=5433|UniProtKB=P48551 P48551 IFNAR2 PTHR20859:SF84 INTERFERON/INTERLEUKIN RECEPTOR INTERFERON ALPHA_BETA RECEPTOR 2 transmembrane signaling receptor activity#GO:0004888;cytokine receptor activity#GO:0004896;signaling receptor activity#GO:0038023;immune receptor activity#GO:0140375;molecular transducer activity#GO:0060089 response to stress#GO:0006950;response to biotic stimulus#GO:0009607;cellular process#GO:0009987;immune response#GO:0006955;signal transduction#GO:0007165;defense response to symbiont#GO:0140546;defense response to other organism#GO:0098542;response to cytokine#GO:0034097;response to chemical#GO:0042221;response to other organism#GO:0051707;biological regulation#GO:0065007;cell surface receptor signaling pathway#GO:0007166;innate immune response#GO:0045087;defense response#GO:0006952;response to external stimulus#GO:0009605;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;response to external biotic stimulus#GO:0043207;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;type I interferon-mediated signaling pathway#GO:0060337;immune system process#GO:0002376;cytokine-mediated signaling pathway#GO:0019221;cell communication#GO:0007154;response to peptide#GO:1901652 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=21078|UniProtKB=Q7Z4H3 Q7Z4H3 HDDC2 PTHR11845:SF13 5'-DEOXYNUCLEOTIDASE HDDC2 5'-DEOXYNUCLEOTIDASE HDDC2 catalytic activity#GO:0003824;5'-nucleotidase activity#GO:0008253;hydrolase activity, acting on ester bonds#GO:0016788;nucleotidase activity#GO:0008252;phosphatase activity#GO:0016791;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=2867|UniProtKB=Q02127 Q02127 DHODH PTHR48109:SF4 DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627 nucleotide biosynthetic process#GO:0009165;nucleotide metabolic process#GO:0009117;organophosphate biosynthetic process#GO:0090407;ribonucleotide metabolic process#GO:0009259;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;nucleobase-containing small molecule metabolic process#GO:0055086;nucleobase metabolic process#GO:0009112;nucleoside phosphate biosynthetic process#GO:1901293;carbohydrate derivative biosynthetic process#GO:1901137;pyrimidine nucleobase metabolic process#GO:0006206;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;carbohydrate derivative metabolic process#GO:1901135;pyrimidine-containing compound metabolic process#GO:0072527;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;ribose phosphate biosynthetic process#GO:0046390 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;mitochondrial inner membrane#GO:0005743;organelle envelope#GO:0031967;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;intracellular organelle#GO:0043229 metabolite interconversion enzyme#PC00262;dehydrogenase#PC00092 De novo pyrimidine ribonucleotides biosythesis#P02740>Dihydrooratate oxidase#P02927 HUMAN|HGNC=8705|UniProtKB=Q9Y5G6 Q9Y5G6 PCDHGA7 PTHR24028:SF234 CADHERIN-87A PROTOCADHERIN GAMMA-A7 cell adhesion#GO:0007155;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 cadherin#PC00057;cell adhesion molecule#PC00069 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HUMAN|HGNC=15962|UniProtKB=Q9HC52 Q9HC52 CBX8 PTHR46389:SF1 POLYCOMB GROUP PROTEIN PC CHROMOBOX PROTEIN HOMOLOG 8 chromatin binding#GO:0003682;binding#GO:0005488 negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355 transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;PRC1 complex#GO:0035102;intracellular protein-containing complex#GO:0140535;PcG protein complex#GO:0031519;nucleus#GO:0005634;chromatin#GO:0000785;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ubiquitin ligase complex#GO:0000151;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;chromosome#GO:0005694;nuclear ubiquitin ligase complex#GO:0000152;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=19770|UniProtKB=Q6ZVZ8 Q6ZVZ8 ASB18 PTHR24118:SF76 POTE ANKYRIN DOMAIN ANKYRIN REPEAT AND SOCS BOX PROTEIN 18 ubiquitin-like ligase-substrate adaptor activity#GO:1990756;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;enzyme-substrate adaptor activity#GO:0140767 ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238 transferase complex#GO:1990234;catalytic complex#GO:1902494;Cul5-RING ubiquitin ligase complex#GO:0031466;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535 membrane traffic protein#PC00150 HUMAN|HGNC=19311|UniProtKB=Q8IXF0 Q8IXF0 NPAS3 PTHR23043:SF30 HYPOXIA-INDUCIBLE FACTOR 1 ALPHA NEURONAL PAS DOMAIN-CONTAINING PROTEIN 3 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=15568|UniProtKB=Q9H299 Q9H299 SH3BGRL3 PTHR12232:SF3 SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN 3 organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=6115|UniProtKB=P48200 P48200 IREB2 PTHR11670:SF31 ACONITASE/IRON-RESPONSIVE ELEMENT FAMILY MEMBER IRON-RESPONSIVE ELEMENT-BINDING PROTEIN 2 catalytic activity#GO:0003824;hydro-lyase activity#GO:0016836;carbon-oxygen lyase activity#GO:0016835;nucleic acid binding#GO:0003676;binding#GO:0005488;small molecule binding#GO:0036094;mRNA binding#GO:0003729;iron-sulfur cluster binding#GO:0051536;RNA binding#GO:0003723;lyase activity#GO:0016829 intracellular iron ion homeostasis#GO:0006879;homeostatic process#GO:0042592;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion homeostasis#GO:0050801;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;inorganic ion homeostasis#GO:0098771;intracellular monoatomic cation homeostasis#GO:0030003;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031 Methylcitrate cycle#P02754>Aconitase#P03028 HUMAN|HGNC=336|UniProtKB=P30556 P30556 AGTR1 PTHR24228:SF11 B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR TYPE-1 ANGIOTENSIN II RECEPTOR transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930 regulation of blood pressure#GO:0008217;blood circulation#GO:0008015;cellular response to nitrogen compound#GO:1901699;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;response to peptide hormone#GO:0043434;developmental process#GO:0032502;system process#GO:0003008;defense response#GO:0006952;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;cellular response to peptide hormone stimulus#GO:0071375;circulatory system process#GO:0003013;inflammatory response#GO:0006954;cell communication#GO:0007154;anatomical structure development#GO:0048856;system development#GO:0048731;response to nitrogen compound#GO:1901698;renal system development#GO:0072001;kidney development#GO:0001822;response to stress#GO:0006950;response to hormone#GO:0009725;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987;response to chemical#GO:0042221;multicellular organism development#GO:0007275;animal organ development#GO:0048513;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;cellular response to hormone stimulus#GO:0032870;signaling#GO:0023052;G protein-coupled receptor signaling pathway#GO:0007186;positive regulation of cytosolic calcium ion concentration#GO:0007204;cellular response to chemical stimulus#GO:0070887;animal gross anatomical part developmental process#GO:0160108;response to oxygen-containing compound#GO:1901700;regulation of biological quality#GO:0065008 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 Angiotensin II-stimulated signaling through G proteins and beta-arrestin#P05911>AT1-R#P05924 HUMAN|HGNC=23375|UniProtKB=Q14C86 Q14C86 GAPVD1 PTHR23101:SF25 RAB GDP/GTP EXCHANGE FACTOR GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1 molecular function regulator activity#GO:0098772;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;protein binding#GO:0005515;small GTPase binding#GO:0031267;enzyme regulator activity#GO:0030234;enzyme binding#GO:0019899;guanyl-nucleotide exchange factor activity#GO:0005085;binding#GO:0005488 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cytosol#GO:0005829;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;endocytic vesicle#GO:0030139;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 guanyl-nucleotide exchange factor#PC00113;protein-binding activity modulator#PC00095 HUMAN|HGNC=27994|UniProtKB=A8MQ14 A8MQ14 ZNF850 PTHR24376:SF260 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 850 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=18411|UniProtKB=Q3KNW1 Q3KNW1 SNAI3 PTHR24388:SF40 ZINC FINGER PROTEIN ZINC FINGER PROTEIN SNAI3 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=8774|UniProtKB=P54750 P54750 PDE1A PTHR11347:SF34 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE DUAL SPECIFICITY CALCIUM_CALMODULIN-DEPENDENT 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 1A hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;cyclic-nucleotide phosphodiesterase activity#GO:0004112;phosphoric diester hydrolase activity#GO:0008081;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578 regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of cell communication#GO:0010646;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;negative regulation of response to stimulus#GO:0048585;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532 neuronal cell body#GO:0043025;somatodendritic compartment#GO:0036477;cellular anatomical structure#GO:0110165;cell body#GO:0044297 phosphodiesterase#PC00185;hydrolase#PC00121 CCKR signaling map#P06959>PDE#P07161 HUMAN|HGNC=1862|UniProtKB=O95813 O95813 CER1 PTHR15273:SF4 DAN DOMAIN FAMILY MEMBER 5 CERBERUS receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092;determination of left/right symmetry#GO:0007368;cellular response to stimulus#GO:0051716;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;pattern specification process#GO:0007389;cell communication#GO:0007154;anatomical structure development#GO:0048856;system development#GO:0048731;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regionalization#GO:0003002;negative regulation of response to stimulus#GO:0048585;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;specification of symmetry#GO:0009799;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;regulation of response to stimulus#GO:0048583;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;circulatory system development#GO:0072359;signaling#GO:0023052;negative regulation of signaling#GO:0023057;animal gross anatomical part developmental process#GO:0160108;regulation of signaling#GO:0023051;negative regulation of cell communication#GO:0010648;signal transduction#GO:0007165;cellular process#GO:0009987;heart development#GO:0007507;negative regulation of signal transduction#GO:0009968;determination of bilateral symmetry#GO:0009855;anterior/posterior pattern specification#GO:0009952;left/right pattern formation#GO:0060972;multicellular organism development#GO:0007275;animal organ development#GO:0048513;anterior/posterior axis specification#GO:0009948 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 Wnt signaling pathway#P00057>Cerebus#P01445 HUMAN|HGNC=15669|UniProtKB=Q8N103 Q8N103 TAGAP PTHR23179:SF26 T-CELL ACTIVATION RHO GTPASE ACTIVATING PROTEIN-RELATED T-CELL ACTIVATION RHO GTPASE-ACTIVATING PROTEIN molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;enzyme activator activity#GO:0008047 protein-binding activity modulator#PC00095;G-protein modulator#PC00022;GTPase-activating protein#PC00257 HUMAN|HGNC=29265|UniProtKB=Q9P2G4 Q9P2G4 MAP10 PTHR21831:SF2 MICROTUBULE-ASSOCIATED PROTEIN 10 MICROTUBULE-ASSOCIATED PROTEIN 10 protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;microtubule binding#GO:0008017;binding#GO:0005488 regulation of cytokinesis#GO:0032465;nuclear division#GO:0000280;mitotic nuclear division#GO:0140014;cell cycle process#GO:0022402;regulation of biological process#GO:0050789;positive regulation of cell cycle process#GO:0090068;sister chromatid segregation#GO:0000819;nuclear chromosome segregation#GO:0098813;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;regulation of cell cycle#GO:0051726;cytoplasmic microtubule organization#GO:0031122;mitotic spindle organization#GO:0007052;chromosome segregation#GO:0007059;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;spindle assembly#GO:0051225;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;spindle elongation#GO:0051231;positive regulation of cell cycle#GO:0045787;cytoskeleton organization#GO:0007010;regulation of cell cycle process#GO:0010564;cellular component assembly#GO:0022607;regulation of cell division#GO:0051302;organelle assembly#GO:0070925;supramolecular fiber organization#GO:0097435;microtubule cytoskeleton organization#GO:0000226;organelle fission#GO:0048285;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cell cycle#GO:0007049;regulation of cellular process#GO:0050794;mitotic cell cycle#GO:0000278;chromosome organization#GO:0051276;mitotic cell cycle process#GO:1903047;spindle organization#GO:0007051;mitotic spindle assembly#GO:0090307;positive regulation of cellular process#GO:0048522;mitotic sister chromatid segregation#GO:0000070;biological regulation#GO:0065007 polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;spindle#GO:0005819;centrosome#GO:0005813;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;mitotic spindle pole#GO:0097431;microtubule cytoskeleton#GO:0015630;spindle midzone#GO:0051233;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;microtubule#GO:0005874;intracellular organelle#GO:0043229;mitotic spindle#GO:0072686;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasmic microtubule#GO:0005881;midbody#GO:0030496;spindle pole#GO:0000922 non-motor microtubule binding protein#PC00166;cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=6515|UniProtKB=Q9NRM7 Q9NRM7 LATS2 PTHR24356:SF149 SERINE/THREONINE-PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE LATS2 protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096 positive regulation of apoptotic process#GO:0043065;mitotic cell cycle process#GO:1903047;G1/S transition of mitotic cell cycle#GO:0000082;regulation of apoptotic process#GO:0042981;biological regulation#GO:0065007;regulation of multicellular organismal process#GO:0051239;hippo signaling#GO:0035329;cell cycle G1/S phase transition#GO:0044843;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;mitotic cell cycle phase transition#GO:0044772;response to stimulus#GO:0050896;mitotic cell cycle#GO:0000278;regulation of cellular process#GO:0050794;cell cycle phase transition#GO:0044770;positive regulation of programmed cell death#GO:0043068;signaling#GO:0023052;regulation of developmental process#GO:0050793;cell cycle#GO:0007049;regulation of programmed cell death#GO:0043067;regulation of growth#GO:0040008;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell cycle process#GO:0022402 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytoskeleton#GO:0005856;spindle#GO:0005819;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;spindle pole#GO:0000922;microtubule cytoskeleton#GO:0015630;nucleus#GO:0005634 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=20271|UniProtKB=Q8NEJ9 Q8NEJ9 NGDN PTHR13237:SF9 SOMETHING ABOUT SILENCING PROTEIN 10-RELATED NEUROGUIDIN RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;maturation of SSU-rRNA#GO:0030490;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;ribosomal small subunit biogenesis#GO:0042274 nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;small-subunit processome#GO:0032040;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;preribosome#GO:0030684;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HUMAN|HGNC=11862|UniProtKB=O60478 O60478 GPR137B PTHR15146:SF0 INTEGRAL MEMBRANE PROTEIN GPR137 INTEGRAL MEMBRANE PROTEIN GPR137B negative regulation of multicellular organismal process#GO:0051241;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;positive regulation of cell communication#GO:0010647;regulation of tissue remodeling#GO:0034103;positive regulation of TOR signaling#GO:0032008;regulation of hemopoiesis#GO:1903706;regulation of cell development#GO:0060284;positive regulation of cellular process#GO:0048522;positive regulation of TORC1 signaling#GO:1904263;regulation of metabolic process#GO:0019222;regulation of bone remodeling#GO:0046850;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of immune system process#GO:0002683;positive regulation of response to stimulus#GO:0048584;regulation of cell differentiation#GO:0045595;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;negative regulation of cellular process#GO:0048523;regulation of catabolic process#GO:0009894;regulation of TORC1 signaling#GO:1903432;regulation of multicellular organismal development#GO:2000026;regulation of biological process#GO:0050789;regulation of autophagy#GO:0010506;negative regulation of biological process#GO:0048519;regulation of signaling#GO:0023051;regulation of bone resorption#GO:0045124;regulation of intracellular signal transduction#GO:1902531;regulation of myeloid cell differentiation#GO:0045637;positive regulation of signaling#GO:0023056;regulation of TOR signaling#GO:0032006;positive regulation of biological process#GO:0048518;regulation of multicellular organismal process#GO:0051239 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;lytic vacuole membrane#GO:0098852;lysosome#GO:0005764;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;vacuolar membrane#GO:0005774;lytic vacuole#GO:0000323;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane#GO:0016020;lysosomal membrane#GO:0005765;cytoplasm#GO:0005737;vacuole#GO:0005773 HUMAN|HGNC=16112|UniProtKB=A0PJX2 A0PJX2 TLDC2 PTHR23354:SF65 NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED TLD DOMAIN-CONTAINING PROTEIN 2 response to stress#GO:0006950;response to stimulus#GO:0050896;response to oxidative stress#GO:0006979 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=15851|UniProtKB=Q96P71 Q96P71 NECAB3 PTHR12178:SF3 EF-HAND DOMAIN-CONTAINING PROTEIN N-TERMINAL EF-HAND CALCIUM-BINDING PROTEIN 3 regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;Golgi apparatus#GO:0005794;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi stack#GO:0005795;Golgi apparatus subcompartment#GO:0098791;Golgi cis cisterna#GO:0000137;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;Golgi cisterna#GO:0031985;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 HUMAN|HGNC=19350|UniProtKB=Q6UW63 Q6UW63 POGLUT2 PTHR12203:SF21 KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED PROTEIN O-GLUCOSYLTRANSFERASE 2 transferase activity#GO:0016740;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;glycosyltransferase activity#GO:0016757;glucosyltransferase activity#GO:0046527 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 HUMAN|HGNC=14336|UniProtKB=Q9HB19 Q9HB19 PLEKHA2 PTHR14336:SF5 TANDEM PH DOMAIN CONTAINING PROTEIN PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 2 phospholipid binding#GO:0005543;anion binding#GO:0043168;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;lipid binding#GO:0008289;phosphatidylinositol bisphosphate binding#GO:1902936 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;membrane#GO:0016020;cell periphery#GO:0071944 HUMAN|HGNC=32467|UniProtKB=B4DX44 B4DX44 ZNF736 PTHR24384:SF98 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED ZINC FINGER PROTEIN 736 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700 regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218 HUMAN|HGNC=16170|UniProtKB=Q9NTX9 Q9NTX9 FAM217B PTHR22145:SF3 SI:CH211-266K22.6 PROTEIN FAM217B HUMAN|HGNC=9770|UniProtKB=Q15771 Q15771 RAB30 PTHR47977:SF64 RAS-RELATED PROTEIN RAB RAS-RELATED PROTEIN RAB-30 catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleotide binding#GO:0000166;anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167;GTPase activity#GO:0003924;hydrolase activity#GO:0016787;ribonucleotide binding#GO:0032553;hydrolase activity, acting on acid anhydrides#GO:0016817;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;carbohydrate derivative binding#GO:0097367;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;guanyl nucleotide binding#GO:0019001;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;nucleoside phosphate binding#GO:1901265;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561 transport#GO:0006810;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;localization#GO:0051179 Golgi stack#GO:0005795;Golgi apparatus subcompartment#GO:0098791;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;Golgi cisterna#GO:0031985;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227 small GTPase#PC00208 HUMAN|HGNC=7050|UniProtKB=Q13296 Q13296 SCGB2A2 PTHR14037:SF7 MAMMAGLOBIN-RELATED MAMMAGLOBIN-A cellular process#GO:0009987;signal transduction#GO:0007165;nuclear receptor-mediated steroid hormone signaling pathway#GO:0030518;response to hormone#GO:0009725;biological regulation#GO:0065007;cellular response to lipid#GO:0071396;response to lipid#GO:0033993;response to chemical#GO:0042221;nuclear receptor-mediated signaling pathway#GO:0141193;cellular response to steroid hormone stimulus#GO:0071383;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;steroid hormone receptor signaling pathway#GO:0043401;response to endogenous stimulus#GO:0009719;intracellular receptor signaling pathway#GO:0030522;signaling#GO:0023052;regulation of cellular process#GO:0050794;cellular response to hormone stimulus#GO:0032870;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;response to steroid hormone#GO:0048545;cellular response to chemical stimulus#GO:0070887;intracellular signal transduction#GO:0035556;hormone-mediated signaling pathway#GO:0009755;cell communication#GO:0007154 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=25144|UniProtKB=Q8N398 Q8N398 VWA5B2 PTHR46299:SF2 VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5B2-RELATED VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5B2 HUMAN|HGNC=16133|UniProtKB=Q96BZ9 Q96BZ9 TBC1D20 PTHR20913:SF10 TBC1 DOMAIN FAMILY MEMBER 20/GTPASE TBC1 DOMAIN FAMILY MEMBER 20 molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047 intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;transport#GO:0006810;cellular component organization or biogenesis#GO:0071840;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;organelle organization#GO:0006996;cellular component organization#GO:0016043;establishment of localization in cell#GO:0051649;Golgi organization#GO:0007030;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;endomembrane system organization#GO:0010256 endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane#GO:0016020;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HUMAN|HGNC=461|UniProtKB=Q99217 Q99217 AMELX PTHR46794:SF2 AMELOGENIN, Y ISOFORM AMELOGENIN, X ISOFORM extracellular matrix structural constituent#GO:0005201;structural molecule activity#GO:0005198 anatomical structure formation involved in morphogenesis#GO:0048646;animal organ development#GO:0048513;anatomical structure development#GO:0048856;developmental process#GO:0032502;biomineral tissue development#GO:0031214;enamel mineralization#GO:0070166;animal gross anatomical part developmental process#GO:0160108;odontogenesis#GO:0042476;tissue development#GO:0009888;animal organ morphogenesis#GO:0009887;odontogenesis of dentin-containing tooth#GO:0042475;amelogenesis#GO:0097186;anatomical structure morphogenesis#GO:0009653 extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical structure#GO:0110165 HUMAN|HGNC=29599|UniProtKB=Q6TDU7 Q6TDU7 DNAI7 PTHR20929:SF11 LUNG ADENOMA SUSCEPTIBILITY 1-RELATED DYNEIN AXONEMAL INTERMEDIATE CHAIN 7 protein binding#GO:0005515;binding#GO:0005488;microtubule binding#GO:0008017;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;cilium#GO:0005929;membraneless organelle#GO:0043228;axoneme#GO:0005930;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;ciliary plasm#GO:0097014;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737 HUMAN|HGNC=6145|UniProtKB=Q13797 Q13797 ITGA9 PTHR23220:SF69 INTEGRIN ALPHA INTEGRIN ALPHA-9 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cell communication#GO:0007154;cell-substrate adhesion#GO:0031589;cell surface receptor signaling pathway#GO:0007166;cell-matrix adhesion#GO:0007160;cell adhesion#GO:0007155;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell-cell adhesion#GO:0098609;integrin-mediated signaling pathway#GO:0007229 signaling receptor complex#GO:0043235;integrin complex#GO:0008305;membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;protein complex involved in cell adhesion#GO:0098636;plasma membrane protein complex#GO:0098797;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cell surface#GO:0009986;plasma membrane#GO:0005886 integrin#PC00126;cell adhesion molecule#PC00069 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Integrin#P00853;Integrin signalling pathway#P00034>Integrin alpha#P00941 HUMAN|HGNC=17494|UniProtKB=Q5T442 Q5T442 GJC2 PTHR11984:SF52 CONNEXIN GAP JUNCTION GAMMA-2 PROTEIN passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;wide pore channel activity#GO:0022829;channel activity#GO:0015267 cellular process#GO:0009987;regulation of biological process#GO:0050789;biological regulation#GO:0065007;signaling#GO:0023052;cell-cell signaling#GO:0007267;cell communication#GO:0007154 cell-cell junction#GO:0005911;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;cell junction#GO:0030054;anchoring junction#GO:0070161 cell junction protein#PC00070;gap junction#PC00105 HUMAN|HGNC=20983|UniProtKB=Q8N987 Q8N987 NECAB1 PTHR12178:SF11 EF-HAND DOMAIN-CONTAINING PROTEIN N-TERMINAL EF-HAND CALCIUM-BINDING PROTEIN 1 regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=9310|UniProtKB=Q15173 Q15173 PPP2R5B PTHR10257:SF4 SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT BETA ISOFORM enzyme activator activity#GO:0008047;phosphatase regulator activity#GO:0019208;enzyme regulator activity#GO:0030234;phosphatase activator activity#GO:0019211;protein phosphatase regulator activity#GO:0019888;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 chromosome organization#GO:0051276;meiotic sister chromatid cohesion#GO:0051177;sister chromatid cohesion#GO:0007062;cellular component organization or biogenesis#GO:0071840;cell cycle process#GO:0022402;cellular process#GO:0009987;cellular component organization#GO:0016043;cell cycle#GO:0007049;organelle organization#GO:0006996 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;protein serine/threonine phosphatase complex#GO:0008287 protein phosphatase#PC00195;protein modifying enzyme#PC00260 EGF receptor signaling pathway#P00018>PP2A#P00547;Wnt signaling pathway#P00057>PP2A#P01438;FGF signaling pathway#P00021>PP2A#P00629 HUMAN|HGNC=23380|UniProtKB=Q9NY56 Q9NY56 OBP2A PTHR11430:SF129 LIPOCALIN ODORANT-BINDING PROTEIN 2A-RELATED extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 transfer/carrier protein#PC00219 HUMAN|HGNC=26421|UniProtKB=Q96NG8 Q96NG8 ZNF582 PTHR24381:SF115 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 582 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=30713|UniProtKB=Q96M93 Q96M93 ADAD1 PTHR10910:SF103 EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN ADENOSINE DEAMINASE DOMAIN-CONTAINING PROTEIN 1 tRNA-specific adenosine deaminase activity#GO:0008251;double-stranded RNA binding#GO:0003725;binding#GO:0005488;nucleic acid binding#GO:0003676;catalytic activity, acting on a tRNA#GO:0140101;adenosine deaminase activity#GO:0004000;hydrolase activity#GO:0016787;RNA binding#GO:0003723;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on RNA#GO:0140098;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;deaminase activity#GO:0019239;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810 RNA biosynthetic process#GO:0032774;adenosine to inosine editing#GO:0006382;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;base conversion or substitution editing#GO:0016553;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634 RNA metabolism protein#PC00031 HUMAN|HGNC=24886|UniProtKB=Q9Y2L6 Q9Y2L6 FRMD4B PTHR46079:SF1 FERM DOMAIN-CONTAINING PROTEIN 4 FERM DOMAIN-CONTAINING PROTEIN 4B cell-cell junction#GO:0005911;bicellular tight junction#GO:0005923;cellular anatomical structure#GO:0110165;apical junction complex#GO:0043296;adherens junction#GO:0005912;anchoring junction#GO:0070161;cell junction#GO:0030054;tight junction#GO:0070160 HUMAN|HGNC=6307|UniProtKB=P35968 P35968 KDR PTHR24416:SF45 TYROSINE-PROTEIN KINASE RECEPTOR VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 catalytic activity, acting on a protein#GO:0140096;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;transferase activity, transferring phosphorus-containing groups#GO:0016772;molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714;signaling receptor activity#GO:0038023;transferase activity#GO:0016740;kinase activity#GO:0016301;growth factor binding#GO:0019838;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein binding#GO:0005515;protein kinase activity#GO:0004672;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888 cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;regulation of multicellular organismal process#GO:0051239;cell surface receptor signaling pathway#GO:0007166;regulation of MAPK cascade#GO:0043408;vasculature development#GO:0001944;anatomical structure formation involved in morphogenesis#GO:0048646;regulation of anatomical structure morphogenesis#GO:0022603;multicellular organism development#GO:0007275;regulation of multicellular organismal development#GO:2000026;positive regulation of multicellular organismal process#GO:0051240;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;positive regulation of angiogenesis#GO:0045766;blood vessel morphogenesis#GO:0048514;positive regulation of cell population proliferation#GO:0008284;positive regulation of cell motility#GO:2000147;signaling#GO:0023052;circulatory system development#GO:0072359;response to stimulus#GO:0050896;cell differentiation#GO:0030154;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;animal gross anatomical part developmental process#GO:0160108;angiogenesis#GO:0001525;positive regulation of cell migration#GO:0030335;positive regulation of cellular process#GO:0048522;tube development#GO:0035295;regulation of locomotion#GO:0040012;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;epithelial cell differentiation#GO:0030855;tissue development#GO:0009888;cell migration#GO:0016477;epithelium development#GO:0060429;regulation of response to stimulus#GO:0048583;positive regulation of developmental process#GO:0051094;developmental process#GO:0032502;regulation of cell migration#GO:0030334;endothelial cell differentiation#GO:0045446;regulation of vasculature development#GO:1901342;positive regulation of locomotion#GO:0040017;cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;blood vessel development#GO:0001568;tube morphogenesis#GO:0035239;regulation of cell communication#GO:0010646;regulation of developmental process#GO:0050793;cell motility#GO:0048870;regulation of cellular process#GO:0050794;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of angiogenesis#GO:0045765;system development#GO:0048731;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of cell population proliferation#GO:0042127;cell communication#GO:0007154;regulation of cell motility#GO:2000145 membrane#GO:0016020;signaling receptor complex#GO:0043235;cell periphery#GO:0071944;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 Angiogenesis#P00005>VEGFR-2#P00222;VEGF signaling pathway#P00056>VEGFR-2#P01403 HUMAN|HGNC=24818|UniProtKB=Q9P0K8 Q9P0K8 FOXJ2 PTHR46078:SF1 FORKHEAD BOX PROTEIN J2 FAMILY MEMBER FORKHEAD BOX PROTEIN J2 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246 HUMAN|HGNC=29119|UniProtKB=O94888 O94888 UBXN7 PTHR23322:SF6 FAS-ASSOCIATED PROTEIN UBX DOMAIN-CONTAINING PROTEIN 7 binding#GO:0005488;ubiquitin binding#GO:0043130;protein binding#GO:0005515 catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 scaffold/adaptor protein#PC00226 HUMAN|HGNC=20421|UniProtKB=Q8N448 Q8N448 LNX2 PTHR19964:SF33 MULTIPLE PDZ DOMAIN PROTEIN LIGAND OF NUMB PROTEIN X 2 ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;ubiquitin-protein transferase activity#GO:0004842;catalytic activity, acting on a protein#GO:0140096 scaffold/adaptor protein#PC00226 Notch signaling pathway#P00045>LNXp80#P01111 HUMAN|HGNC=7370|UniProtKB=Q8N5Y2 Q8N5Y2 MSL3 PTHR10880:SF55 MORTALITY FACTOR 4-LIKE PROTEIN MSL COMPLEX SUBUNIT 3 chromatin binding#GO:0003682;histone reader activity#GO:0140566;binding#GO:0005488;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;chromatin-protein adaptor activity#GO:0140463 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 transferase complex#GO:1990234;histone acetyltransferase complex#GO:0000123;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;chromatin#GO:0000785;intracellular membraneless organelle#GO:0043232;NuA4 histone acetyltransferase complex#GO:0035267;H4 histone acetyltransferase complex#GO:1902562;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;protein acetyltransferase complex#GO:0031248;acetyltransferase complex#GO:1902493;intracellular anatomical structure#GO:0005622;chromosome#GO:0005694;organelle#GO:0043226;cellular anatomical structure#GO:0110165 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=7896|UniProtKB=Q14207 Q14207 NPAT PTHR15087:SF14 PROTEIN NPAT PROTEIN NPAT transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=8964|UniProtKB=Q14442 Q14442 PIGH PTHR15231:SF1 PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT H PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT H phospholipid metabolic process#GO:0006644;liposaccharide metabolic process#GO:1903509;glycerolipid metabolic process#GO:0046486;GPI anchored protein biosynthesis#GO:0180046;phospholipid biosynthetic process#GO:0008654;glycolipid metabolic process#GO:0006664;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;glycolipid biosynthetic process#GO:0009247;organophosphate biosynthetic process#GO:0090407;protein metabolic process#GO:0019538;biosynthetic process#GO:0009058;GPI anchor biosynthetic process#GO:0006506;glycerophospholipid metabolic process#GO:0006650;lipid biosynthetic process#GO:0008610;protein maturation#GO:0051604;gene expression#GO:0010467;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;glycerolipid biosynthetic process#GO:0045017;organophosphate metabolic process#GO:0019637;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;GPI anchor metabolic process#GO:0006505;glycerophospholipid biosynthetic process#GO:0046474;lipid metabolic process#GO:0006629;metabolic process#GO:0008152 membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;endoplasmic reticulum subcompartment#GO:0098827;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;endoplasmic reticulum#GO:0005783;transferase complex#GO:1990234;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;endoplasmic reticulum protein-containing complex#GO:0140534 transferase#PC00220;glycosyltransferase#PC00111 HUMAN|HGNC=23133|UniProtKB=Q9BTE0 Q9BTE0 NAT9 PTHR13256:SF16 N-ACETYLTRANSFERASE 9 ALPHA_BETA-TUBULIN-N-ACETYLTRANSFERASE 9 acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;protein N-acetyltransferase activity#GO:0034212;catalytic activity, acting on a protein#GO:0140096;protein-N-terminal amino-acid acetyltransferase activity#GO:0004596;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein N-acyltransferase activity#GO:0140186;N-acetyltransferase activity#GO:0008080;acetyltransferase activity#GO:0016407;acyltransferase activity#GO:0016746 regulation of microtubule polymerization or depolymerization#GO:0031110;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of cellular component biogenesis#GO:0044089;positive regulation of protein polymerization#GO:0032273;regulation of microtubule cytoskeleton organization#GO:0070507;biological regulation#GO:0065007;regulation of microtubule-based process#GO:0032886;positive regulation of cellular component organization#GO:0051130;positive regulation of organelle organization#GO:0010638;regulation of microtubule polymerization#GO:0031113;regulation of protein-containing complex assembly#GO:0043254;regulation of organelle organization#GO:0033043;regulation of supramolecular fiber organization#GO:1902903;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;regulation of protein polymerization#GO:0032271;regulation of cellular component biogenesis#GO:0044087 HUMAN|HGNC=24934|UniProtKB=Q9HCI5 Q9HCI5 MAGEE1 PTHR11736:SF9 MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN MELANOMA-ASSOCIATED ANTIGEN E1 negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 scaffold/adaptor protein#PC00226 HUMAN|HGNC=6331|UniProtKB=P43628 P43628 KIR2DL3 PTHR11738:SF168 MHC CLASS I NK CELL RECEPTOR IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN-RELATED transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;immune receptor activity#GO:0140375;molecular transducer activity#GO:0060089 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;immune response-regulating cell surface receptor signaling pathway#GO:0002768;signaling#GO:0023052;biological regulation#GO:0065007;signal transduction#GO:0007165;regulation of biological process#GO:0050789;immune response-regulating signaling pathway#GO:0002764;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;regulation of immune response#GO:0050776;cell surface receptor signaling pathway#GO:0007166;regulation of response to stimulus#GO:0048583 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=35414|UniProtKB=A6NKP2 A6NKP2 SDR42E2 PTHR10366:SF241 NAD DEPENDENT EPIMERASE/DEHYDRATASE SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E MEMBER 2-RELATED oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 metabolite interconversion enzyme#PC00262;lyase#PC00144;dehydratase#PC00091 HUMAN|HGNC=21718|UniProtKB=Q96CH1 Q96CH1 GPR146 PTHR24226:SF3 G-PROTEIN COUPLED RECEPTOR 182 AND ESTROGEN RECEPTOR 1 G PROTEIN-COUPLED RECEPTOR 146 transmembrane signaling receptor activity#GO:0004888;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway#GO:0007193;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HUMAN|HGNC=13920|UniProtKB=O95872 O95872 GPANK1 PTHR20923:SF1 BAT4 PROTEIN-RELATED G PATCH DOMAIN AND ANKYRIN REPEAT-CONTAINING PROTEIN 1 HUMAN|HGNC=33196|UniProtKB=Q00G26 Q00G26 PLIN5 PTHR14024:SF9 PERILIPIN PERILIPIN-5 positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789;lipid storage#GO:0019915;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of localization#GO:0032879 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;lipid droplet#GO:0005811;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytosol#GO:0005829 scaffold/adaptor protein#PC00226 HUMAN|HGNC=6551|UniProtKB=Q9UJU2 Q9UJU2 LEF1 PTHR10373:SF11 TRANSCRIPTION FACTOR 7 FAMILY MEMBER LYMPHOID ENHANCER-BINDING FACTOR 1 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 canonical Wnt signaling pathway#GO:0060070;cell communication#GO:0007154;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;Wnt signaling pathway#GO:0016055;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;signaling#GO:0023052;cell surface receptor signaling pathway#GO:0007166;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;chromatin#GO:0000785 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 Cadherin signaling pathway#P00012>TCF/LEF#P00465;Alzheimer disease-presenilin pathway#P00004>TCF/LEF#P00143;Wnt signaling pathway#P00057>TCF#P01437 HUMAN|HGNC=7940|UniProtKB=P16860 P16860 NPPB PTHR14066:SF10 ATRIAL NATRIURETIC FACTOR PRECURSOR NATRIURETIC PEPTIDES B hormone activity#GO:0005179;molecular function activator activity#GO:0140677;protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488;hormone receptor binding#GO:0051427;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545 cyclic nucleotide biosynthetic process#GO:0009190;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;G protein-coupled receptor signaling pathway#GO:0007186;ribonucleotide metabolic process#GO:0009259;nucleotide biosynthetic process#GO:0009165;regulation of biological quality#GO:0065008;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;purine nucleotide metabolic process#GO:0006163;regulation of biological process#GO:0050789;purine-containing compound metabolic process#GO:0072521;phosphorus metabolic process#GO:0006793;signaling#GO:0023052;response to stimulus#GO:0050896;small molecule metabolic process#GO:0044281;cyclic purine nucleotide metabolic process#GO:0052652;cell surface receptor signaling pathway#GO:0007166;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative biosynthetic process#GO:1901137;receptor guanylyl cyclase signaling pathway#GO:0007168;signal transduction#GO:0007165;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;ribose phosphate biosynthetic process#GO:0046390;regulation of systemic arterial blood pressure#GO:0003073;circulatory system process#GO:0003013;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;organophosphate biosynthetic process#GO:0090407;cGMP biosynthetic process#GO:0006182;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;neuropeptide signaling pathway#GO:0007218;nucleoside phosphate metabolic process#GO:0006753;regulation of cellular process#GO:0050794;cyclic nucleotide metabolic process#GO:0009187;system process#GO:0003008;nucleoside phosphate biosynthetic process#GO:1901293;carbohydrate derivative metabolic process#GO:1901135;cGMP metabolic process#GO:0046068;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;regulation of blood pressure#GO:0008217;biological regulation#GO:0065007;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;blood circulation#GO:0008015;multicellular organismal process#GO:0032501 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=20469|UniProtKB=Q86YQ2 Q86YQ2 BPIFA4P PTHR47015:SF3 BPI FOLD-CONTAINING FAMILY A MEMBER 1 BPIFA4P PROTEIN-RELATED multicellular organismal-level homeostasis#GO:0048871;homeostatic process#GO:0042592;multicellular organismal process#GO:0032501;chemical homeostasis#GO:0048878 HUMAN|HGNC=21579|UniProtKB=Q6ZNC8 Q6ZNC8 MBOAT1 PTHR13906:SF6 PORCUPINE MEMBRANE-BOUND GLYCEROPHOSPHOLIPID O-ACYLTRANSFERASE 1 catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746 lipid modification#GO:0030258;lipid metabolic process#GO:0006629;cellular process#GO:0009987;metabolic process#GO:0008152;primary metabolic process#GO:0044238 membrane#GO:0016020;cellular anatomical structure#GO:0110165 acetyltransferase#PC00038 HUMAN|HGNC=15531|UniProtKB=Q99848 Q99848 EBNA1BP2 PTHR13028:SF0 RRNA PROCESSING PROTEIN EBNA1-BINDING PROTEIN-RELATED RRNA-PROCESSING PROTEIN EBP2-RELATED nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 nucleic acid biosynthetic process#GO:0141187;ribosomal large subunit biogenesis#GO:0042273;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467 membraneless organelle#GO:0043228;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;preribosome, large subunit precursor#GO:0030687;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;nucleolus#GO:0005730;preribosome#GO:0030684;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle lumen#GO:0043233 HUMAN|HGNC=6236|UniProtKB=Q03721 Q03721 KCNC4 PTHR11537:SF126 VOLTAGE-GATED POTASSIUM CHANNEL VOLTAGE-GATED POTASSIUM CHANNEL KCNC4 potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843 transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;action potential#GO:0001508;metal ion transport#GO:0030001;transport#GO:0006810;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;cellular process#GO:0009987;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805 cell periphery#GO:0071944;membrane#GO:0016020;presynaptic membrane#GO:0042734;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;monoatomic ion channel complex#GO:0034702;plasma membrane region#GO:0098590;neuron projection membrane#GO:0032589;voltage-gated potassium channel complex#GO:0008076;axon terminus#GO:0043679;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;plasma membrane bounded cell projection#GO:0120025;distal axon#GO:0150034;neuron projection terminus#GO:0044306;neuronal cell body#GO:0043025;dendritic tree#GO:0097447;axon#GO:0030424;dendrite#GO:0030425;transmembrane transporter complex#GO:1902495;neuron projection#GO:0043005;presynapse#GO:0098793;cell leading edge#GO:0031252;protein-containing complex#GO:0032991;synaptic membrane#GO:0097060;cation channel complex#GO:0034703;transporter complex#GO:1990351;cell junction#GO:0030054;cell body#GO:0044297;postsynapse#GO:0098794;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;synapse#GO:0045202;leading edge membrane#GO:0031256;postsynaptic membrane#GO:0045211;cell projection membrane#GO:0031253 voltage-gated ion channel#PC00241;ion channel#PC00133 HUMAN|HGNC=20809|UniProtKB=Q8TF32 Q8TF32 ZNF431 PTHR24384:SF88 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED ZINC FINGER PROTEIN 431 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA-binding transcription factor#PC00218 HUMAN|HGNC=15622|UniProtKB=Q96RL6 Q96RL6 SIGLEC11 PTHR12035:SF127 SIALIC ACID BINDING IMMUNOGLOBULIN-LIKE LECTIN SIALIC ACID-BINDING IG-LIKE LECTIN 11 carbohydrate derivative binding#GO:0097367;ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;carboxylic acid binding#GO:0031406;binding#GO:0005488;organic acid binding#GO:0043177 cellular process#GO:0009987;cell adhesion#GO:0007155 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 immunoglobulin superfamily cell adhesion molecule#PC00125;cell adhesion molecule#PC00069 HUMAN|HGNC=562|UniProtKB=O94973 O94973 AP2A2 PTHR22780:SF30 ADAPTIN, ALPHA/GAMMA/EPSILON AP-2 COMPLEX SUBUNIT ALPHA-2 cargo adaptor activity#GO:0140312;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 vesicle-mediated transport#GO:0016192;endocytosis#GO:0006897;clathrin-dependent endocytosis#GO:0072583;cellular process#GO:0009987;receptor-mediated endocytosis#GO:0006898;establishment of localization#GO:0051234;import into cell#GO:0098657;localization#GO:0051179;transport#GO:0006810 endomembrane system#GO:0012505;plasma membrane#GO:0005886;vesicle membrane#GO:0012506;membrane#GO:0016020;cell periphery#GO:0071944;organelle membrane#GO:0031090;clathrin-coated vesicle#GO:0030136;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;vesicle#GO:0031982;plasma membrane protein complex#GO:0098797;membrane coat#GO:0030117;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;vesicle coat#GO:0030120;cytoplasm#GO:0005737;clathrin-coated endocytic vesicle#GO:0045334;clathrin-coated vesicle membrane#GO:0030665;AP-type membrane coat adaptor complex#GO:0030119;bounding membrane of organelle#GO:0098588;clathrin vesicle coat#GO:0030125;organelle#GO:0043226;cellular anatomical structure#GO:0110165;clathrin coat#GO:0030118;coated vesicle membrane#GO:0030662;intracellular vesicle#GO:0097708;clathrin-coated pit#GO:0005905;coated membrane#GO:0048475;endocytic vesicle#GO:0030139;coated vesicle#GO:0030135;intracellular organelle#GO:0043229 membrane traffic protein#PC00150 Huntington disease#P00029>alpha-Adaptin#P00782 HUMAN|HGNC=22196|UniProtKB=O15069 O15069 NACAD PTHR21713:SF1 NASCENT POLYPEPTIDE ASSOCIATED COMPLEX ALPHA SUBUNIT-RELATED NAC-ALPHA DOMAIN-CONTAINING PROTEIN 1 protein targeting to membrane#GO:0006612;localization within membrane#GO:0051668;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;establishment of protein localization to membrane#GO:0090150;establishment of protein localization#GO:0045184;cellular process#GO:0009987;protein targeting#GO:0006605 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=12572|UniProtKB=P13051 P13051 UNG PTHR11264:SF0 URACIL-DNA GLYCOSYLASE URACIL-DNA GLYCOSYLASE hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787;catalytic activity, acting on DNA#GO:0140097;DNA N-glycosylase activity#GO:0019104;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;base-excision repair#GO:0006284;response to stress#GO:0006950;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139 DNA glycosylase#PC00010 HUMAN|HGNC=15764|UniProtKB=Q9GZN2 Q9GZN2 TGIF2 PTHR11850:SF412 HOMEOBOX PROTEIN TRANSCRIPTION FACTORS HOMEOBOX PROTEIN TGIF2 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 HUMAN|HGNC=13125|UniProtKB=Q68EA5 Q68EA5 ZNF57 PTHR24379:SF133 KRAB AND ZINC FINGER DOMAIN-CONTAINING ZINC FINGER PROTEIN 57 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218;zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=26430|UniProtKB=Q70UQ0 Q70UQ0 IKBIP PTHR21734:SF10 INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE-INTERACTING PROTEIN INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE-INTERACTING PROTEIN HUMAN|HGNC=14875|UniProtKB=Q96LA5 Q96LA5 FCRL2 PTHR11481:SF101 IMMUNOGLOBULIN FC RECEPTOR FC RECEPTOR-LIKE PROTEIN 2 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;immune response#GO:0006955;regulation of biological process#GO:0050789;signal transduction#GO:0007165;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cell surface receptor signaling pathway#GO:0007166;immune system process#GO:0002376;cell communication#GO:0007154 membrane#GO:0016020;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell surface#GO:0009986;plasma membrane#GO:0005886 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=13523|UniProtKB=Q9H2X3 Q9H2X3 CLEC4M PTHR22802:SF438 C-TYPE LECTIN SUPERFAMILY MEMBER C-TYPE LECTIN DOMAIN FAMILY 4 MEMBER M small molecule binding#GO:0036094;binding#GO:0005488;monosaccharide binding#GO:0048029;signaling receptor activity#GO:0038023;carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187;molecular transducer activity#GO:0060089 immune response#GO:0006955;immune system process#GO:0002376;response to stimulus#GO:0050896 cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897 membrane traffic protein#PC00150 HUMAN|HGNC=17689|UniProtKB=Q969H6 Q969H6 POP5 PTHR15441:SF2 RIBONUCLEASE P PROTEIN SUBUNIT P14 RIBONUCLEASE P_MRP PROTEIN SUBUNIT POP5 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139 intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;ribonuclease MRP complex#GO:0000172;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;endonuclease complex#GO:1905348;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;multimeric ribonuclease P complex#GO:0030681;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;sno(s)RNA-containing ribonucleoprotein complex#GO:0005732;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;endoribonuclease complex#GO:1902555;ribonuclease P complex#GO:0030677 endoribonuclease#PC00094 HUMAN|HGNC=11908|UniProtKB=Q9Y6Q6 Q9Y6Q6 TNFRSF11A PTHR47134:SF1 TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 11A TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 11A death receptor activity#GO:0005035;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888;protein binding#GO:0005515;molecular transducer activity#GO:0060089;cytokine binding#GO:0019955;signaling receptor activity#GO:0038023 cell development#GO:0048468;signaling#GO:0023052;myeloid cell differentiation#GO:0030099;cell differentiation#GO:0030154;response to stimulus#GO:0050896;positive regulation of multicellular organismal process#GO:0051240;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;leukocyte differentiation#GO:0002521;response to peptide#GO:1901652;regulation of bone resorption#GO:0045124;regulation of multicellular organismal process#GO:0051239;response to cytokine#GO:0034097;response to chemical#GO:0042221;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cell surface receptor signaling pathway#GO:0007166;regulation of cellular process#GO:0050794;ossification#GO:0001503;cellular response to stimulus#GO:0051716;regulation of tissue remodeling#GO:0034103;osteoclast differentiation#GO:0030316;anatomical structure development#GO:0048856;tumor necrosis factor-mediated signaling pathway#GO:0033209;cell communication#GO:0007154;cytokine-mediated signaling pathway#GO:0019221;biological regulation#GO:0065007;hemopoiesis#GO:0030097;multicellular organismal process#GO:0032501;response to tumor necrosis factor#GO:0034612;regulation of bone remodeling#GO:0046850;cellular developmental process#GO:0048869;developmental process#GO:0032502 cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell surface#GO:0009986;plasma membrane#GO:0005886;membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=27051|UniProtKB=Q6ZTI6 Q6ZTI6 RFLNA PTHR31848:SF0 REFILIN-A-RELATED REFILIN-A animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;anatomical structure development#GO:0048856;skeletal system development#GO:0001501;regulation of multicellular organismal development#GO:2000026;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;negative regulation of biological process#GO:0048519;negative regulation of multicellular organismal process#GO:0051241;regulation of developmental process#GO:0050793;animal organ morphogenesis#GO:0009887;regulation of cellular process#GO:0050794;regulation of cell differentiation#GO:0045595;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;animal organ development#GO:0048513;multicellular organism development#GO:0007275;regulation of cell development#GO:0060284;skeletal system morphogenesis#GO:0048705;regulation of multicellular organismal process#GO:0051239;regulation of bone mineralization#GO:0030500;biological regulation#GO:0065007;multicellular organismal process#GO:0032501 HUMAN|HGNC=12155|UniProtKB=P0DTU4 P0DTU4 TRB PTHR23268:SF30 T-CELL RECEPTOR BETA CHAIN T CELL RECEPTOR BETA CHAIN MC.7.G5-RELATED cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=4113|UniProtKB=O14976 O14976 GAK PTHR23172:SF34 AUXILIN/CYCLIN G-ASSOCIATED KINASE-RELATED CYCLIN-G-ASSOCIATED KINASE protein binding#GO:0005515;binding#GO:0005488;clathrin binding#GO:0030276 cellular process#GO:0009987;clathrin-dependent endocytosis#GO:0072583;cellular component organization#GO:0016043;protein-containing complex disassembly#GO:0032984;endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;transport#GO:0006810;protein-containing complex organization#GO:0043933;receptor-mediated endocytosis#GO:0006898;cellular component disassembly#GO:0022411;establishment of localization#GO:0051234;import into cell#GO:0098657;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;vesicle#GO:0031982;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 membrane traffic protein#PC00150 HUMAN|HGNC=33755|UniProtKB=Q6ZW13 Q6ZW13 C16orf86 PTHR37867:SF1 CHROMOSOME 16 OPEN READING FRAME 86 CHROMOSOME 18 C16ORF86 HOMOLOG HUMAN|HGNC=23339|UniProtKB=Q9BR61 Q9BR61 ACBD6 PTHR24119:SF0 ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 6 ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 6 enzyme activator activity#GO:0008047;molecular function regulator activity#GO:0098772;heterocyclic compound binding#GO:1901363;ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265;small molecule binding#GO:0036094;anion binding#GO:0043168;binding#GO:0005488;lipid binding#GO:0008289;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234 plasma membrane#GO:0005886;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cell periphery#GO:0071944;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 HUMAN|HGNC=574|UniProtKB=O00189 O00189 AP4M1 PTHR10529:SF270 AP COMPLEX SUBUNIT MU AP-4 COMPLEX SUBUNIT MU-1 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;cargo adaptor activity#GO:0140312 vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;establishment of localization#GO:0051234;intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;transport#GO:0006810;vacuolar transport#GO:0007034;protein targeting#GO:0006605;cytosolic transport#GO:0016482;cellular localization#GO:0051641;Golgi to vacuole transport#GO:0006896;localization#GO:0051179;post-Golgi vesicle-mediated transport#GO:0006892;lysosomal transport#GO:0007041 Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;Golgi apparatus#GO:0005794;AP-type membrane coat adaptor complex#GO:0030119;membrane protein complex#GO:0098796;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;coated membrane#GO:0048475;membrane coat#GO:0030117;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HUMAN|HGNC=9142|UniProtKB=P54821 P54821 PRRX1 PTHR46385:SF1 PAIRED MESODERM HOMEOBOX PROTEIN 1-RELATED PAIRED MESODERM HOMEOBOX PROTEIN 1 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=23193|UniProtKB=Q9P2Z0 Q9P2Z0 THAP10 PTHR46600:SF11 THAP DOMAIN-CONTAINING THAP DOMAIN-CONTAINING PROTEIN 10 zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=16895|UniProtKB=Q8N6Y2 Q8N6Y2 LRRC17 PTHR24373:SF301 SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN LEUCINE-RICH REPEAT-CONTAINING PROTEIN 17 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=5804|UniProtKB=P01614 P01614 IGKV2D-40 PTHR23267:SF381 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN KAPPA VARIABLE 2-40-RELATED response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=14137|UniProtKB=Q9H910 Q9H910 JPT2 PTHR34930:SF5 GEO05313P1 JUPITER MICROTUBULE ASSOCIATED HOMOLOG 2 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 non-motor microtubule binding protein#PC00166;cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=5456|UniProtKB=O00458 O00458 IFRD1 PTHR12354:SF6 INTERFERON-RELATED DEVELOPMENTAL REGULATOR INTERFERON-RELATED DEVELOPMENTAL REGULATOR 1 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=29631|UniProtKB=Q6UW68 Q6UW68 TMEM205 PTHR46916:SF2 TRANSMEMBRANE PROTEIN 205 TRANSMEMBRANE PROTEIN 205 HUMAN|HGNC=4270|UniProtKB=P09681 P09681 GIP PTHR15211:SF0 GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE GASTRIC INHIBITORY POLYPEPTIDE G protein-coupled receptor binding#GO:0001664;binding#GO:0005488;signaling receptor binding#GO:0005102;protein binding#GO:0005515 response to stress#GO:0006950;response to starvation#GO:0042594;response to nutrient levels#GO:0031667;response to stimulus#GO:0050896 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=34408|UniProtKB=Q68EN5 Q68EN5 MATCAP1 PTHR31817:SF1 FAMILY NOT NAMED MICROTUBULE-ASSOCIATED TYROSINE CARBOXYPEPTIDASE 1 HUMAN|HGNC=11184|UniProtKB=Q00796 Q00796 SORD PTHR43161:SF29 SORBITOL DEHYDROGENASE SORBITOL DEHYDROGENASE oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;alcohol dehydrogenase (NAD+) activity#GO:0004022;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;catalytic activity#GO:0003824 carbohydrate metabolic process#GO:0005975;small molecule catabolic process#GO:0044282;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;hexose biosynthetic process#GO:0019319;primary metabolic process#GO:0044238;hexose metabolic process#GO:0019318;carbohydrate catabolic process#GO:0016052;biosynthetic process#GO:0009058;monosaccharide biosynthetic process#GO:0046364;carbohydrate biosynthetic process#GO:0016051;cellular process#GO:0009987;small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152;monosaccharide metabolic process#GO:0005996;alcohol metabolic process#GO:0006066 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 dehydrogenase#PC00092;oxidoreductase#PC00176 HUMAN|HGNC=21745|UniProtKB=Q7Z5Q1 Q7Z5Q1 CPEB2 PTHR12566:SF8 CYTOPLASMIC POLYADENYLATION ELEMENT BINDING PROTEIN CPEB CYTOPLASMIC POLYADENYLATION ELEMENT-BINDING PROTEIN 2 translation regulator activity#GO:0045182;mRNA 3'-UTR binding#GO:0003730;translation factor activity#GO:0180051;ribonucleoprotein complex binding#GO:0043021;RNA binding#GO:0003723;protein-containing complex binding#GO:0044877;ribosome binding#GO:0043022;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729 biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;negative regulation of translation#GO:0017148 cell junction#GO:0030054;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;neuron projection#GO:0043005;nucleus#GO:0005634 mRNA polyadenylation factor#PC00146 HUMAN|HGNC=3658|UniProtKB=Q9UGM5 Q9UGM5 FETUB PTHR13814:SF10 FETUIN FETUIN-B enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;peptidase regulator activity#GO:0061134;endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772;enzyme inhibitor activity#GO:0004857 fertilization#GO:0009566;reproductive process#GO:0022414;single fertilization#GO:0007338;cellular process#GO:0009987;binding of sperm to zona pellucida#GO:0007339;cell-cell recognition#GO:0009988;sperm-egg recognition#GO:0035036;sexual reproduction#GO:0019953;cell recognition#GO:0008037 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HUMAN|HGNC=26675|UniProtKB=Q8NA31 Q8NA31 TERB1 PTHR14014:SF0 TELOMERE REPEATS-BINDING BOUQUET FORMATION PROTEIN 1 TELOMERE REPEATS-BINDING BOUQUET FORMATION PROTEIN 1 reproductive process#GO:0022414;cellular component organization#GO:0016043;meiosis I#GO:0007127;nuclear chromosome segregation#GO:0098813;meiotic cell cycle process#GO:1903046;cell cycle#GO:0007049;telomere localization#GO:0034397;cell cycle process#GO:0022402;organelle fission#GO:0048285;localization#GO:0051179;organelle localization#GO:0051640;nuclear division#GO:0000280;meiosis I cell cycle process#GO:0061982;telomere tethering at nuclear periphery#GO:0034398;sexual reproduction#GO:0019953;homologous chromosome pairing at meiosis#GO:0007129;chromosome localization#GO:0050000;organelle organization#GO:0006996;cellular process#GO:0009987;meiotic nuclear division#GO:0140013;cellular component organization or biogenesis#GO:0071840;homologous chromosome segregation#GO:0045143;chromosome organization#GO:0051276;meiotic chromosome segregation#GO:0045132;chromosome organization involved in meiotic cell cycle#GO:0070192;meiotic cell cycle#GO:0051321;chromosome segregation#GO:0007059 HUMAN|HGNC=20123|UniProtKB=Q86U10 Q86U10 ASPG PTHR11707:SF28 L-ASPARAGINASE 60 KDA LYSOPHOSPHOLIPASE amidase activity#GO:0004040;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;catalytic activity#GO:0003824;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity#GO:0016787 HUMAN|HGNC=7898|UniProtKB=Q9UHC9 Q9UHC9 NPC1L1 PTHR45727:SF3 NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1 NPC1-LIKE INTRACELLULAR CHOLESTEROL TRANSPORTER 1 alcohol binding#GO:0043178;lipid binding#GO:0008289;cholesterol binding#GO:0015485;steroid binding#GO:0005496;binding#GO:0005488;small molecule binding#GO:0036094;sterol binding#GO:0032934 chemical homeostasis#GO:0048878;transport#GO:0006810;lipid localization#GO:0010876;organic hydroxy compound transport#GO:0015850;system process#GO:0003008;localization#GO:0051179;establishment of localization#GO:0051234;cholesterol homeostasis#GO:0042632;sterol transport#GO:0015918;macromolecule localization#GO:0033036;lipid homeostasis#GO:0055088;homeostatic process#GO:0042592;digestion#GO:0007586;lipid transport#GO:0006869;multicellular organismal process#GO:0032501 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=9204|UniProtKB=P27169 P27169 PON1 PTHR11799:SF16 PARAOXONASE SERUM PARAOXONASE_ARYLESTERASE 1 hydrolase activity, acting on ester bonds#GO:0016788;carboxylic ester hydrolase activity#GO:0052689;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578 small molecule catabolic process#GO:0044282;response to toxic substance#GO:0009636;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;response to chemical#GO:0042221;response to stimulus#GO:0050896;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;carboxylic acid metabolic process#GO:0019752;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 hydrolase#PC00121;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=24222|UniProtKB=Q86Y33 Q86Y33 CDC20B PTHR19918:SF4 CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED CELL DIVISION CYCLE PROTEIN 20 HOMOLOG B enzyme activator activity#GO:0008047;binding#GO:0005488;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;protein-containing complex binding#GO:0044877;enzyme regulator activity#GO:0030234 cellular process#GO:0009987;positive regulation of biological process#GO:0048518;regulation of protein metabolic process#GO:0051246;proteasomal protein catabolic process#GO:0010498;positive regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032436;regulation of proteasomal protein catabolic process#GO:0061136;positive regulation of macromolecule metabolic process#GO:0010604;macromolecule catabolic process#GO:0009057;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;metabolic process#GO:0008152;regulation of biological process#GO:0050789;positive regulation of proteasomal protein catabolic process#GO:1901800;positive regulation of protein metabolic process#GO:0051247;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;anaphase-promoting complex-dependent catabolic process#GO:0031145;positive regulation of metabolic process#GO:0009893;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;regulation of catabolic process#GO:0009894;ubiquitin-dependent protein catabolic process#GO:0006511;positive regulation of catabolic process#GO:0009896;macromolecule metabolic process#GO:0043170;positive regulation of ubiquitin-dependent protein catabolic process#GO:2000060;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of protein catabolic process#GO:0042176;positive regulation of protein catabolic process#GO:0045732;protein metabolic process#GO:0019538;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434 transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;protein-containing complex#GO:0032991;anaphase-promoting complex#GO:0005680;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ubiquitin ligase complex#GO:0000151;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular membrane-bounded organelle#GO:0043231;nuclear ubiquitin ligase complex#GO:0000152;organelle#GO:0043226;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=5018|UniProtKB=A2RU54 A2RU54 HMX2 PTHR46110:SF4 HOMEOBOX PROTEIN HMX HOMEOBOX PROTEIN HMX2 double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 HUMAN|HGNC=13446|UniProtKB=Q9NRM0 Q9NRM0 SLC2A9 PTHR23503:SF35 SOLUTE CARRIER FAMILY 2 SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 9 sugar transmembrane transporter activity#GO:0051119;carbohydrate transmembrane transporter activity#GO:0015144;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 localization#GO:0051179;establishment of localization#GO:0051234;import into cell#GO:0098657;transmembrane transport#GO:0055085;carbohydrate transport#GO:0008643;transport#GO:0006810;import across plasma membrane#GO:0098739;vitamin transport#GO:0051180;carbohydrate transmembrane transport#GO:0034219;D-glucose transmembrane transport#GO:1904659;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 secondary carrier transporter#PC00258 HUMAN|HGNC=14126|UniProtKB=A8MWX3 A8MWX3 WASH4P PTHR23331:SF3 CXYORF1 WAS PROTEIN FAMILY HOMOLOG 4-RELATED vesicle-mediated transport#GO:0016192;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;retrograde transport, endosome to Golgi#GO:0042147;establishment of localization in cell#GO:0051649;Arp2/3 complex-mediated actin nucleation#GO:0034314;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;endosomal transport#GO:0016197;vesicle-mediated transport to the plasma membrane#GO:0098876;actin filament organization#GO:0007015;exocytosis#GO:0006887;intracellular transport#GO:0046907;transport#GO:0006810;endocytic recycling#GO:0032456;actin cytoskeleton organization#GO:0030036;actin nucleation#GO:0045010;export from cell#GO:0140352;cytosolic transport#GO:0016482;cellular component organization#GO:0016043;localization#GO:0051179;cellular localization#GO:0051641;secretion#GO:0046903;supramolecular fiber organization#GO:0097435;secretion by cell#GO:0032940;localization within membrane#GO:0051668;actin filament-based process#GO:0030029 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;recycling endosome#GO:0055037;endosome#GO:0005768;intracellular organelle#GO:0043229 membrane traffic protein#PC00150 HUMAN|HGNC=25079|UniProtKB=Q96HJ3 Q96HJ3 CCDC34 PTHR23247:SF2 NY-REN-41 ANTIGEN L15 -RELATED COILED-COIL DOMAIN-CONTAINING PROTEIN 34 HUMAN|HGNC=8887|UniProtKB=P0DJD9 P0DJD9 PGA5 PTHR47966:SF22 BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED PEPSIN A-3-RELATED hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity#GO:0003824;aspartic-type endopeptidase activity#GO:0004190 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;proteolysis#GO:0006508;metabolic process#GO:0008152;primary metabolic process#GO:0044238;cellular process#GO:0009987 aspartic protease#PC00053;protease#PC00190 HUMAN|HGNC=29385|UniProtKB=Q8NB42 Q8NB42 ZNF527 PTHR24377:SF620 IP01015P-RELATED ZINC FINGER PROTEIN 527 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=17810|UniProtKB=Q4VCS5 Q4VCS5 AMOT PTHR14826:SF6 ANGIOMOTIN ANGIOMOTIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;blood vessel morphogenesis#GO:0048514;signaling#GO:0023052;response to stimulus#GO:0050896;circulatory system development#GO:0072359;animal gross anatomical part developmental process#GO:0160108;establishment or maintenance of cell polarity#GO:0007163;angiogenesis#GO:0001525;cellular process#GO:0009987;signal transduction#GO:0007165;organelle organization#GO:0006996;hippo signaling#GO:0035329;cytoskeleton organization#GO:0007010;anatomical structure formation involved in morphogenesis#GO:0048646;vasculature development#GO:0001944;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;blood vessel development#GO:0001568;tube morphogenesis#GO:0035239;cellular response to stimulus#GO:0051716;establishment of cell polarity#GO:0030010;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;cell motility#GO:0048870;actin filament-based process#GO:0030029;intracellular signal transduction#GO:0035556;system development#GO:0048731;anatomical structure development#GO:0048856;cell communication#GO:0007154;regulation of cell motility#GO:2000145;tube development#GO:0035295;regulation of locomotion#GO:0040012;biological regulation#GO:0065007;cell migration#GO:0016477;multicellular organismal process#GO:0032501;regulation of cell migration#GO:0030334;developmental process#GO:0032502 anchoring junction#GO:0070161;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;cell projection#GO:0042995;intracellular vesicle#GO:0097708;vesicle#GO:0031982;tight junction#GO:0070160;cell junction#GO:0030054;apical junction complex#GO:0043296;bicellular tight junction#GO:0005923;lamellipodium#GO:0030027;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cell-cell junction#GO:0005911;membrane#GO:0016020;cell leading edge#GO:0031252;cell periphery#GO:0071944 HUMAN|HGNC=1723|UniProtKB=Q12834 Q12834 CDC20 PTHR19918:SF3 CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED CELL DIVISION CYCLE PROTEIN 20 HOMOLOG molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;protein-containing complex binding#GO:0044877;enzyme regulator activity#GO:0030234;enzyme activator activity#GO:0008047;binding#GO:0005488 positive regulation of protein catabolic process#GO:0045732;regulation of protein catabolic process#GO:0042176;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434;protein metabolic process#GO:0019538;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;modification-dependent protein catabolic process#GO:0019941;positive regulation of ubiquitin-dependent protein catabolic process#GO:2000060;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;regulation of catabolic process#GO:0009894;macromolecule metabolic process#GO:0043170;positive regulation of catabolic process#GO:0009896;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;biological regulation#GO:0065007;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;positive regulation of metabolic process#GO:0009893;anaphase-promoting complex-dependent catabolic process#GO:0031145;protein catabolic process#GO:0030163;positive regulation of protein metabolic process#GO:0051247;modification-dependent macromolecule catabolic process#GO:0043632;regulation of biological process#GO:0050789;positive regulation of proteasomal protein catabolic process#GO:1901800;metabolic process#GO:0008152;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;macromolecule catabolic process#GO:0009057;positive regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032436;proteasomal protein catabolic process#GO:0010498;positive regulation of macromolecule metabolic process#GO:0010604;regulation of proteasomal protein catabolic process#GO:0061136;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of protein metabolic process#GO:0051246 protein-containing complex#GO:0032991;anaphase-promoting complex#GO:0005680;nucleus#GO:0005634;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234;intracellular membrane-bounded organelle#GO:0043231;cullin-RING ubiquitin ligase complex#GO:0031461;cellular anatomical structure#GO:0110165;nuclear ubiquitin ligase complex#GO:0000152;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=2082|UniProtKB=O15516 O15516 CLOCK PTHR46055:SF2 CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of DNA-templated transcription#GO:0006355;circadian rhythm#GO:0007623;regulation of RNA metabolic process#GO:0051252;rhythmic process#GO:0048511;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;circadian regulation of gene expression#GO:0032922;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;nuclear protein-containing complex#GO:0140513 Circadian clock system#P00015>Clock#P00501 HUMAN|HGNC=32068|UniProtKB=Q5TGZ0 Q5TGZ0 MICOS10 PTHR21304:SF5 MICOS COMPLEX SUBUNIT MIC10 MICOS COMPLEX SUBUNIT MIC10 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=27916|UniProtKB=Q8NDY8 Q8NDY8 TMEM52 PTHR33955:SF2 TRANSMEMBRANE PROTEIN 52 TRANSMEMBRANE PROTEIN 52 HUMAN|HGNC=9411|UniProtKB=P14314 P14314 PRKCSH PTHR12630:SF27 N-LINKED OLIGOSACCHARIDE PROCESSING GLUCOSIDASE 2 SUBUNIT BETA macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;glycoprotein biosynthetic process#GO:0009101;biosynthetic process#GO:0009058;multicellular organismal process#GO:0032501;developmental process#GO:0032502;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;animal organ development#GO:0048513;carbohydrate derivative biosynthetic process#GO:1901137;multicellular organism development#GO:0007275;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487;liver development#GO:0001889;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;anatomical structure development#GO:0048856;protein metabolic process#GO:0019538 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;endoplasmic reticulum protein-containing complex#GO:0140534;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 protein-binding activity modulator#PC00095 HUMAN|HGNC=29450|UniProtKB=Q9BZE0 Q9BZE0 GLIS2 PTHR19818:SF84 ZINC FINGER PROTEIN ZIC AND GLI ZINC FINGER PROTEIN GLIS2 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of DNA-templated transcription#GO:0045892;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;positive regulation of macromolecule metabolic process#GO:0010604;negative regulation of macromolecule biosynthetic process#GO:0010558;positive regulation of biological process#GO:0048518;positive regulation of transcription by RNA polymerase II#GO:0045944;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=341|UniProtKB=P21549 P21549 AGXT PTHR21152:SF40 AMINOTRANSFERASE CLASS V ALANINE--GLYOXYLATE AMINOTRANSFERASE catalytic activity#GO:0003824;transferase activity#GO:0016740;transaminase activity#GO:0008483 proteinogenic amino acid biosynthetic process#GO:0170038;metabolic process#GO:0008152;amino acid biosynthetic process#GO:0008652;small molecule biosynthetic process#GO:0044283;proteinogenic amino acid metabolic process#GO:0170039;monocarboxylic acid catabolic process#GO:0072329;biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;aldehyde catabolic process#GO:0046185;carboxylic acid catabolic process#GO:0046395;aldehyde metabolic process#GO:0006081;cellular process#GO:0009987;oxoacid metabolic process#GO:0043436;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;glyoxylate metabolic process#GO:0046487;small molecule catabolic process#GO:0044282;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;carboxylic acid biosynthetic process#GO:0046394 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;peroxisome#GO:0005777;microbody#GO:0042579;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 transaminase#PC00216;transferase#PC00220 HUMAN|HGNC=8616|UniProtKB=Q02962 Q02962 PAX2 PTHR45636:SF19 PAIRED BOX PROTEIN PAX-6-RELATED-RELATED PAIRED BOX PROTEIN PAX-2 cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;nervous system development#GO:0007399;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;sensory organ development#GO:0007423;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;animal organ development#GO:0048513;multicellular organism development#GO:0007275;regulation of gene expression#GO:0010468;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;animal gross anatomical part developmental process#GO:0160108;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=29545|UniProtKB=Q9H7L9 Q9H7L9 SUDS3 PTHR21964:SF34 BREAST CANCER METASTASIS-SUPPRESSOR 1 SIN3 HISTONE DEACETYLASE COREPRESSOR COMPLEX COMPONENT SDS3 binding#GO:0005488;enzyme binding#GO:0019899;protein binding#GO:0005515;histone deacetylase binding#GO:0042826 negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355 protein-containing complex#GO:0032991;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;histone deacetylase complex#GO:0000118;nucleus#GO:0005634;chromatin#GO:0000785;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;chromosome#GO:0005694;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;catalytic complex#GO:1902494;Sin3-type complex#GO:0070822;intracellular organelle#GO:0043229 HUMAN|HGNC=17735|UniProtKB=Q5T3F8 Q5T3F8 TMEM63B PTHR13018:SF38 PROBABLE MEMBRANE PROTEIN DUF221-RELATED MECHANOSENSITIVE CATION CHANNEL TMEM63B monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;ligand-gated monoatomic cation channel activity#GO:0099094;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;monoatomic ion-gated channel activity#GO:0022839;monoatomic cation transmembrane transporter activity#GO:0008324;calcium-activated cation channel activity#GO:0005227;channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HUMAN|HGNC=23145|UniProtKB=Q8NHW3 Q8NHW3 MAFA PTHR10129:SF30 TRANSCRIPTION FACTOR MAF TRANSCRIPTION FACTOR MAFA nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 protein localization to extracellular region#GO:0071692;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;signal release#GO:0023061;peptide secretion#GO:0002790;secretion#GO:0046903;regulation of DNA-templated transcription#GO:0006355;cell communication#GO:0007154;localization#GO:0051179;regulation of RNA metabolic process#GO:0051252;peptide hormone secretion#GO:0030072;nitrogen compound transport#GO:0071705;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;macromolecule localization#GO:0033036;peptide transport#GO:0015833;regulation of primary metabolic process#GO:0080090;response to glucose#GO:0009749;regulation of nucleobase-containing compound metabolic process#GO:0019219;insulin secretion#GO:0030073;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;transport#GO:0006810;regulation of biosynthetic process#GO:0009889;establishment of localization#GO:0051234;regulation of gene expression#GO:0010468;establishment of protein localization to extracellular region#GO:0035592;intracellular protein localization#GO:0008104;response to hexose#GO:0009746;regulation of hormone levels#GO:0010817;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;signaling#GO:0023052;export from cell#GO:0140352;response to monosaccharide#GO:0034284;response to oxygen-containing compound#GO:1901700;protein secretion#GO:0009306;protein transport#GO:0015031;regulation of biological quality#GO:0065008;hormone secretion#GO:0046879;response to carbohydrate#GO:0009743;secretion by cell#GO:0032940;cellular process#GO:0009987;establishment of protein localization#GO:0045184;response to chemical#GO:0042221;hormone transport#GO:0009914 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 basic leucine zipper transcription factor#PC00056;DNA-binding transcription factor#PC00218 HUMAN|HGNC=14046|UniProtKB=P82921 P82921 MRPS21 PTHR21109:SF13 MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S21 SMALL RIBOSOMAL SUBUNIT PROTEIN BS21M translational protein#PC00263;ribosomal protein#PC00202 HUMAN|HGNC=4124|UniProtKB=Q10471 Q10471 GALNT2 PTHR11675:SF49 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 2 UDP-glycosyltransferase activity#GO:0008194;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757;acetylgalactosaminyltransferase activity#GO:0008376;catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758;polypeptide N-acetylgalactosaminyltransferase activity#GO:0004653 protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;biosynthetic process#GO:0009058;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein O-linked glycosylation#GO:0006493;carbohydrate derivative metabolic process#GO:1901135;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 glycosyltransferase#PC00111;transferase#PC00220 HUMAN|HGNC=1135|UniProtKB=Q13410 Q13410 BTN1A1 PTHR24100:SF139 BUTYROPHILIN BUTYROPHILIN SUBFAMILY 1 MEMBER A1 protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 positive regulation of immune system process#GO:0002684;cellular process#GO:0009987;activation of immune response#GO:0002253;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;antigen receptor-mediated signaling pathway#GO:0050851;regulation of multicellular organismal process#GO:0051239;cell surface receptor signaling pathway#GO:0007166;immune response-activating signaling pathway#GO:0002757;immune response-regulating signaling pathway#GO:0002764;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signaling#GO:0023052;immune system process#GO:0002376;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of cytokine production#GO:0001817;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;T cell receptor signaling pathway#GO:0050852;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;cellular response to stimulus#GO:0051716;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;immune response-activating cell surface receptor signaling pathway#GO:0002429;regulation of immune response#GO:0050776;cell communication#GO:0007154 membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell surface#GO:0009986;plasma membrane#GO:0005886 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=20759|UniProtKB=Q9H1K0 Q9H1K0 RBSN PTHR13510:SF44 FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED RABENOSYN-5 HUMAN|HGNC=8949|UniProtKB=P36952 P36952 SERPINB5 PTHR11461:SF55 SERINE PROTEASE INHIBITOR, SERPIN SERPIN B5 enzyme regulator activity#GO:0030234;serine-type endopeptidase inhibitor activity#GO:0004867;molecular function inhibitor activity#GO:0140678;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414;peptidase regulator activity#GO:0061134;endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772;enzyme inhibitor activity#GO:0004857 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease inhibitor#PC00191 p53 pathway#P00059>Maspin#G01569 HUMAN|HGNC=1452|UniProtKB=P27482 P27482 CALML3 PTHR23050:SF557 CALCIUM BINDING PROTEIN CALMODULIN-LIKE PROTEIN 3 binding#GO:0005488;small molecule binding#GO:0036094;kinase activator activity#GO:0019209;ion binding#GO:0043167;calcium ion binding#GO:0005509;metal ion binding#GO:0046872;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;cation binding#GO:0043169;protein serine/threonine kinase activator activity#GO:0043539;enzyme activator activity#GO:0008047;protein kinase activator activity#GO:0030295;protein kinase regulator activity#GO:0019887;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207 biological regulation#GO:0065007;regulation of calcium ion transport#GO:0051924;intracellular signaling cassette#GO:0141124;response to chemical#GO:0042221;regulation of monoatomic ion transport#GO:0043269;signal transduction#GO:0007165;regulation of monoatomic ion transmembrane transport#GO:0034765;cellular process#GO:0009987;detection of stimulus#GO:0051606;regulation of transport#GO:0051049;regulation of localization#GO:0032879;regulation of release of sequestered calcium ion into cytosol#GO:0051279;calcium-mediated signaling#GO:0019722;response to metal ion#GO:0010038;regulation of monoatomic cation transmembrane transport#GO:1904062;signaling#GO:0023052;regulation of metal ion transport#GO:0010959;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;detection of chemical stimulus#GO:0009593;calcineurin-mediated signaling#GO:0097720;regulation of transmembrane transport#GO:0034762;intracellular signal transduction#GO:0035556;response to calcium ion#GO:0051592;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;myelin sheath#GO:0043209;microtubule cytoskeleton#GO:0015630;nucleus#GO:0005634;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;centrosome#GO:0005813;intracellular organelle#GO:0043229 calcium-binding protein#PC00060;calmodulin-related#PC00061 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Calmodulin#P00755 HUMAN|HGNC=23158|UniProtKB=Q9NPJ4 Q9NPJ4 PNRC2 PTHR15405:SF6 PROLINE-RICH NUCLEAR RECEPTOR COACTIVATOR PROLINE-RICH NUCLEAR RECEPTOR COACTIVATOR 2 biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;nucleobase-containing compound catabolic process#GO:0034655;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;nucleic acid catabolic process#GO:0141188;macromolecule metabolic process#GO:0043170;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;metabolic process#GO:0008152;negative regulation of cellular process#GO:0048523;macromolecule catabolic process#GO:0009057;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay#GO:0000184;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;RNA metabolic process#GO:0016070;RNA catabolic process#GO:0006401 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;P-body#GO:0000932;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;organelle#GO:0043226;ribonucleoprotein granule#GO:0035770;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;nucleus#GO:0005634 HUMAN|HGNC=37490|UniProtKB=E9PQR5 E9PQR5 NPIPB8 PTHR15438:SF4 NUCLEAR PORE COMPLEX INTERACTING PROTEIN NUCLEAR PORE COMPLEX-INTERACTING PROTEIN FAMILY MEMBER B15-RELATED HUMAN|HGNC=21416|UniProtKB=Q92485 Q92485 SMPDL3B PTHR10340:SF25 SPHINGOMYELIN PHOSPHODIESTERASE ACID SPHINGOMYELINASE-LIKE PHOSPHODIESTERASE 3B hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578;phosphoric diester hydrolase activity#GO:0008081;hydrolase activity#GO:0016787 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 phosphodiesterase#PC00185;hydrolase#PC00121 HUMAN|HGNC=28918|UniProtKB=Q8WUY8 Q8WUY8 NAT14 PTHR13947:SF51 GNAT FAMILY N-ACETYLTRANSFERASE N-ACETYLTRANSFERASE 14-RELATED acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;catalytic activity#GO:0003824;transferase activity#GO:0016740 acetyltransferase#PC00038 HUMAN|HGNC=21556|UniProtKB=Q5TFE4 Q5TFE4 NT5DC1 PTHR12103:SF38 5'-NUCLEOTIDASE DOMAIN-CONTAINING 5'-NUCLEOTIDASE DOMAIN-CONTAINING PROTEIN 1 phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791 nucleotide phosphatase#PC00173;hydrolase#PC00121;phosphatase#PC00181 HUMAN|HGNC=30941|UniProtKB=Q8N5P1 Q8N5P1 ZC3H8 PTHR13119:SF32 ZINC FINGER CCCH DOMAIN-CONTAINING PROTEI ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 8 DNA-binding transcription repressor activity#GO:0001217;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;transcription regulator activity#GO:0140110 negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;negative regulation of metabolic process#GO:0009892;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription elongation#GO:0032784 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233 zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=164|UniProtKB=P35609 P35609 ACTN2 PTHR11915:SF429 SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN ALPHA-ACTININ-2 protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;actin filament binding#GO:0051015;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092 cell development#GO:0048468;muscle structure development#GO:0061061;actin cytoskeleton organization#GO:0030036;cell differentiation#GO:0030154;muscle cell differentiation#GO:0042692;cellular component organization#GO:0016043;muscle cell development#GO:0055001;anatomical structure development#GO:0048856;actin filament-based process#GO:0030029;animal gross anatomical part developmental process#GO:0160108;cytoskeleton organization#GO:0007010;cellular process#GO:0009987;organelle organization#GO:0006996;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;developmental process#GO:0032502 supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;cortical actin cytoskeleton#GO:0030864;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;membrane#GO:0016020;cell periphery#GO:0071944;Z disc#GO:0030018;contractile muscle fiber#GO:0043292;membraneless organelle#GO:0043228;sarcomere#GO:0030017;cell junction#GO:0030054;cytoskeleton#GO:0005856;I band#GO:0031674;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cell projection#GO:0042995;cortical cytoskeleton#GO:0030863;actin cytoskeleton#GO:0015629;cell cortex#GO:0005938;myofibril#GO:0030016;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;intracellular organelle#GO:0043229 actin or actin-binding cytoskeletal protein#PC00041 Integrin signalling pathway#P00034>alpha actinin#P00928 HUMAN|HGNC=20951|UniProtKB=Q9C009 Q9C009 FOXQ1 PTHR11829:SF206 FORKHEAD BOX PROTEIN FORKHEAD BOX PROTEIN Q1 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;developmental process#GO:0032502;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=339|UniProtKB=P35414 P35414 APLNR PTHR24228:SF31 B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR APELIN RECEPTOR transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930 cellular process#GO:0009987;signal transduction#GO:0007165;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;heart development#GO:0007507;developmental process#GO:0032502;vasculature development#GO:0001944;animal organ development#GO:0048513;multicellular organism development#GO:0007275;cellular response to stimulus#GO:0051716;blood vessel development#GO:0001568;regulation of biological process#GO:0050789;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;circulatory system development#GO:0072359;animal gross anatomical part developmental process#GO:0160108;G protein-coupled receptor signaling pathway#GO:0007186;system development#GO:0048731;anatomical structure development#GO:0048856;cell communication#GO:0007154 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=19079|UniProtKB=Q9UF11 Q9UF11 PLEKHB1 PTHR14309:SF7 EXPRESSED PROTEIN PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY B MEMBER 1 biological regulation#GO:0065007;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of cell differentiation#GO:0045595 membrane#GO:0016020;cellular anatomical structure#GO:0110165 HUMAN|HGNC=4530|UniProtKB=P48146 P48146 NPBWR2 PTHR24229:SF18 NEUROPEPTIDES RECEPTOR NEUROPEPTIDES B_W RECEPTOR TYPE 2 molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;binding#GO:0005488;neuropeptide binding#GO:0042923;peptide binding#GO:0042277;transmembrane signaling receptor activity#GO:0004888 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;neuropeptide signaling pathway#GO:0007218;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005 G-protein coupled receptor#PC00021 HUMAN|HGNC=5164|UniProtKB=Q9Y251 Q9Y251 HPSE PTHR46145:SF3 HEPARANASE HEPARANASE developmental process#GO:0032502;anatomical structure formation involved in morphogenesis#GO:0048646;vasculature development#GO:0001944;multicellular organism development#GO:0007275;cellular process#GO:0009987;response to wounding#GO:0009611;response to stress#GO:0006950;tube development#GO:0035295;multicellular organismal process#GO:0032501;cell-matrix adhesion#GO:0007160;cell adhesion#GO:0007155;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;wound healing#GO:0042060;cell-substrate adhesion#GO:0031589;angiogenesis#GO:0001525;anatomical structure development#GO:0048856;anatomical structure morphogenesis#GO:0009653;tube morphogenesis#GO:0035239;blood vessel development#GO:0001568;blood vessel morphogenesis#GO:0048514;response to stimulus#GO:0050896;circulatory system development#GO:0072359 cellular anatomical structure#GO:0110165;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576 glycosidase#PC00110 HUMAN|HGNC=16361|UniProtKB=Q9P202 Q9P202 WHRN PTHR23116:SF37 PDZ DOMAIN CONTAINING WHIRLIN AND HARMONIN-RELATED WHIRLIN sensory perception#GO:0007600;sensory perception of mechanical stimulus#GO:0050954;embryonic organ development#GO:0048568;system development#GO:0048731;anatomical structure development#GO:0048856;animal organ morphogenesis#GO:0009887;developmental process#GO:0032502;sensory organ development#GO:0007423;epidermis development#GO:0008544;system process#GO:0003008;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;inner ear development#GO:0048839;plasma membrane bounded cell projection organization#GO:0120036;epithelium development#GO:0060429;tissue development#GO:0009888;epithelial cell differentiation#GO:0030855;epidermal cell differentiation#GO:0009913;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699;nervous system process#GO:0050877;animal gross anatomical part developmental process#GO:0160108;neuron development#GO:0048666;ear development#GO:0043583;anatomical structure morphogenesis#GO:0009653;inner ear receptor cell stereocilium organization#GO:0060122;cellular component organization#GO:0016043;cell development#GO:0048468;sensory perception of sound#GO:0007605;cell projection organization#GO:0030030;cell differentiation#GO:0030154;sensory organ morphogenesis#GO:0090596;cell morphogenesis#GO:0000902;neuron differentiation#GO:0030182;cellular component organization or biogenesis#GO:0071840;embryonic morphogenesis#GO:0048598;multicellular organism development#GO:0007275;animal organ development#GO:0048513;cellular process#GO:0009987;neuron projection development#GO:0031175;inner ear morphogenesis#GO:0042472;hair cell differentiation#GO:0035315;embryo development#GO:0009790;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667 neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;stereocilium#GO:0032420;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;actin-based cell projection#GO:0098858;actin cytoskeleton#GO:0015629;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;cilium#GO:0005929;cluster of actin-based cell projections#GO:0098862;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085 HUMAN|HGNC=18357|UniProtKB=Q9P2F6 Q9P2F6 ARHGAP20 PTHR23179:SF28 T-CELL ACTIVATION RHO GTPASE ACTIVATING PROTEIN-RELATED RHO GTPASE-ACTIVATING PROTEIN 20 enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772 GTPase-activating protein#PC00257;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HUMAN|HGNC=2957|UniProtKB=P49184 P49184 DNASE1L1 PTHR11371:SF28 DEOXYRIBONUCLEASE DEOXYRIBONUCLEASE-1-LIKE 1 catalytic activity, acting on DNA#GO:0140097;endonuclease activity#GO:0004519;DNA endonuclease activity, producing 5'-phosphomonoesters#GO:0016888;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;DNA nuclease activity#GO:0004536;hydrolase activity, acting on ester bonds#GO:0016788;DNA endonuclease activity#GO:0004520;hydrolase activity#GO:0016787;DNA binding#GO:0003677;nuclease activity#GO:0004518;nucleic acid binding#GO:0003676;binding#GO:0005488 catabolic process#GO:0009056;nucleobase-containing compound metabolic process#GO:0006139;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;nucleobase-containing compound catabolic process#GO:0034655;nucleic acid catabolic process#GO:0141188;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;macromolecule catabolic process#GO:0009057;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA catabolic process#GO:0006308 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 endodeoxyribonuclease#PC00093 HUMAN|HGNC=1780|UniProtKB=P50750 P50750 CDK9 PTHR24056:SF233 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE 9 protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;cyclin-dependent protein serine/threonine kinase activity#GO:0004693;cyclin-dependent protein kinase activity#GO:0097472;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824 metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;transcription by RNA polymerase II#GO:0006366;macromolecule metabolic process#GO:0043170;DNA-templated transcription elongation#GO:0006354;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;transcription elongation by RNA polymerase II#GO:0006368;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351 intracellular membrane-bounded organelle#GO:0043231;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;protein kinase complex#GO:1902911;membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554;transferase complex#GO:1990234;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=3449|UniProtKB=O75460 O75460 ERN1 PTHR13954:SF17 IRE1-RELATED SERINE_THREONINE-PROTEIN KINASE_ENDORIBONUCLEASE IRE1 phosphotransferase activity, alcohol group as acceptor#GO:0016773;nuclease activity#GO:0004518;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;catalytic activity, acting on RNA#GO:0140098;RNA endonuclease activity#GO:0004521;endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 apoptotic signaling pathway#GO:0097190;biological regulation#GO:0065007;signal transduction#GO:0007165;cellular process#GO:0009987;endoplasmic reticulum unfolded protein response#GO:0030968;response to stress#GO:0006950;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;response to unfolded protein#GO:0006986;intrinsic apoptotic signaling pathway#GO:0097193;cellular response to stress#GO:0033554;cellular response to topologically incorrect protein#GO:0035967;response to endoplasmic reticulum stress#GO:0034976;cellular response to unfolded protein#GO:0034620;response to topologically incorrect protein#GO:0035966;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress#GO:0070059;regulation of biological process#GO:0050789;apoptotic process#GO:0006915;cellular response to stimulus#GO:0051716;cell death#GO:0008219;programmed cell death#GO:0012501 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;membrane#GO:0016020;endoplasmic reticulum protein-containing complex#GO:0140534;organelle membrane#GO:0031090;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane protein complex#GO:0098796;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827 tyrosine protein kinase receptor#PC00233;transmembrane signal receptor#PC00197 Alzheimer disease-presenilin pathway#P00004>Ire-1 C-terminal fragment#P00125;Alzheimer disease-presenilin pathway#P00004>Ire-1 N-terminal fragment#P00110;Alzheimer disease-presenilin pathway#P00004>Ire-1#P00144 HUMAN|HGNC=25817|UniProtKB=Q5VYS8 Q5VYS8 TUT7 PTHR12271:SF34 POLY A POLYMERASE CID PAP -RELATED TERMINAL URIDYLYLTRANSFERASE 7 catalytic activity, acting on RNA#GO:0140098;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;nucleotidyltransferase activity#GO:0016779 regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;positive regulation of mRNA catabolic process#GO:0061014;regulation of RNA metabolic process#GO:0051252;regulation of RNA stability#GO:0043487;regulation of nucleobase-containing compound metabolic process#GO:0019219;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of primary metabolic process#GO:0080090;nucleobase-containing compound catabolic process#GO:0034655;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;nucleic acid catabolic process#GO:0141188;macromolecule metabolic process#GO:0043170;positive regulation of catabolic process#GO:0009896;regulation of biosynthetic process#GO:0009889;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;regulation of mRNA stability#GO:0043488;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;positive regulation of metabolic process#GO:0009893;RNA metabolic process#GO:0016070;regulation of biological quality#GO:0065008;RNA catabolic process#GO:0006401;modification-dependent macromolecule catabolic process#GO:0043632;positive regulation of macromolecule metabolic process#GO:0010604;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;RNA destabilization#GO:0050779;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of mRNA metabolic process#GO:1903311;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;mRNA destabilization#GO:0061157;positive regulation of mRNA metabolic process#GO:1903313 nucleotidyltransferase#PC00174 HUMAN|HGNC=11060|UniProtKB=P52569 P52569 SLC7A2 PTHR43243:SF35 INNER MEMBRANE TRANSPORTER YGJI-RELATED CATIONIC AMINO ACID TRANSPORTER 2 amino acid transmembrane transporter activity#GO:0015171;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 localization#GO:0051179;establishment of localization#GO:0051234;transport#GO:0006810;amino acid transport#GO:0006865 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 secondary carrier transporter#PC00258;amino acid transporter#PC00046 HUMAN|HGNC=16784|UniProtKB=Q9BZQ8 Q9BZQ8 NIBAN1 PTHR14392:SF3 NIBAN FAMILY MEMBER PROTEIN NIBAN 1 HUMAN|HGNC=21706|UniProtKB=Q8N2F6 Q8N2F6 ARMC10 PTHR15712:SF19 ARMADILLO REPEAT CONTAINING PROTEIN ARMADILLO REPEAT-CONTAINING PROTEIN 10 cellular localization#GO:0051641;localization#GO:0051179;microtubule-based transport#GO:0099111;organelle localization#GO:0051640;axonal transport#GO:0098930;establishment of organelle localization#GO:0051656;microtubule-based movement#GO:0007018;mitochondrion localization#GO:0051646;microtubule-based process#GO:0007017;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;transport#GO:0006810;intracellular transport#GO:0046907;organelle transport along microtubule#GO:0072384;cytoskeleton-dependent intracellular transport#GO:0030705;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;axo-dendritic transport#GO:0008088 mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 scaffold/adaptor protein#PC00226 HUMAN|HGNC=16188|UniProtKB=Q9BQ89 Q9BQ89 FAM110A PTHR14758:SF4 AGAP005440-PA PROTEIN FAM110A HUMAN|HGNC=5414|UniProtKB=Q01628 Q01628 IFITM3 PTHR13999:SF4 INTERFERON INDUCIBLE TRANSMEMBRANE PROTEIN INTERFERON-INDUCED TRANSMEMBRANE PROTEIN 3 immune response#GO:0006955;biological regulation#GO:0065007;response to other organism#GO:0051707;innate immune response#GO:0045087;response to external stimulus#GO:0009605;defense response#GO:0006952;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;response to external biotic stimulus#GO:0043207;cytokine-mediated signaling pathway#GO:0019221;cell communication#GO:0007154;response to virus#GO:0009615;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;defense response to symbiont#GO:0140546;signal transduction#GO:0007165;cellular process#GO:0009987;response to type II interferon#GO:0034341;response to cytokine#GO:0034097;response to chemical#GO:0042221;defense response to other organism#GO:0098542;cell surface receptor signaling pathway#GO:0007166;negative regulation of biological process#GO:0048519;defense response to virus#GO:0051607;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052;immune system process#GO:0002376;type I interferon-mediated signaling pathway#GO:0060337;response to peptide#GO:1901652 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 defense/immunity protein#PC00090 HUMAN|HGNC=26023|UniProtKB=Q8N9H8 Q8N9H8 EXD3 PTHR47765:SF2 3'-5' EXONUCLEASE DOMAIN-CONTAINING PROTEIN EXONUCLEASE MUT-7 HOMOLOG HUMAN|HGNC=20274|UniProtKB=Q9BY43 Q9BY43 CHMP4A PTHR22761:SF14 CHARGED MULTIVESICULAR BODY PROTEIN CHARGED MULTIVESICULAR BODY PROTEIN 4A multivesicular body sorting pathway#GO:0071985;nuclear membrane organization#GO:0071763;late endosome to vacuole transport via multivesicular body sorting pathway#GO:0032511;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;vesicle-mediated transport#GO:0016192;cellular component assembly#GO:0022607;endosome transport via multivesicular body sorting pathway#GO:0032509;transport#GO:0006810;vacuolar transport#GO:0007034;intracellular transport#GO:0046907;vesicle budding from membrane#GO:0006900;nuclear envelope organization#GO:0006998;vesicle organization#GO:0016050;endosomal transport#GO:0016197;establishment of localization#GO:0051234;nucleus organization#GO:0006997;cellular component organization or biogenesis#GO:0071840;membrane assembly#GO:0071709;cellular component organization#GO:0016043;late endosome to vacuole transport#GO:0045324;cellular localization#GO:0051641;localization#GO:0051179 endomembrane system#GO:0012505;late endosome#GO:0005770;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;plasma membrane#GO:0005886;nuclear envelope#GO:0005635;membrane#GO:0016020;vesicle membrane#GO:0012506;cell periphery#GO:0071944;nucleus#GO:0005634;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;cytoplasmic side of membrane#GO:0098562;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasmic side of plasma membrane#GO:0009898;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;organelle envelope#GO:0031967;vesicle#GO:0031982;side of membrane#GO:0098552;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endosome membrane#GO:0010008;endosome#GO:0005768;intracellular organelle#GO:0043229 membrane traffic protein#PC00150 HUMAN|HGNC=17539|UniProtKB=Q96T92 Q96T92 INSM2 PTHR15065:SF6 INSULINOMA-ASSOCIATED 1 INSULINOMA-ASSOCIATED PROTEIN 2 sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription repressor activity#GO:0001217;transcription regulator activity#GO:0140110;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700 regulation of cell cycle process#GO:0010564;nervous system development#GO:0007399;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;multicellular organism development#GO:0007275;neuron differentiation#GO:0030182;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;regulation of cell cycle#GO:0051726;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;negative regulation of transcription by RNA polymerase II#GO:0000122;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252 nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;transcription repressor complex#GO:0017053;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=3128|UniProtKB=P32249 P32249 GPR183 PTHR24237:SF7 G-PROTEIN COUPLED RECEPTOR G PROTEIN-COUPLED RECEPTOR 183 signaling receptor activity#GO:0038023;steroid binding#GO:0005496;G protein-coupled receptor activity#GO:0004930;lipid binding#GO:0008289;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488;sterol binding#GO:0032934 positive regulation of leukocyte activation#GO:0002696;leukocyte activation involved in immune response#GO:0002366;immune effector process#GO:0002252;regulation of B cell proliferation#GO:0030888;B cell activation#GO:0042113;positive regulation of mononuclear cell proliferation#GO:0032946;regulation of leukocyte proliferation#GO:0070663;cellular process#GO:0009987;signal transduction#GO:0007165;lymphocyte activation involved in immune response#GO:0002285;positive regulation of biological process#GO:0048518;regulation of mononuclear cell proliferation#GO:0032944;regulation of B cell activation#GO:0050864;positive regulation of immune system process#GO:0002684;regulation of multicellular organismal process#GO:0051239;response to chemical#GO:0042221;lymphocyte activation#GO:0046649;taxis#GO:0042330;B cell activation involved in immune response#GO:0002312;immune system process#GO:0002376;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;cell activation involved in immune response#GO:0002263;positive regulation of multicellular organismal process#GO:0051240;regulation of cell activation#GO:0050865;regulation of biological process#GO:0050789;regulation of leukocyte activation#GO:0002694;positive regulation of cell population proliferation#GO:0008284;regulation of lymphocyte activation#GO:0051249;signaling#GO:0023052;response to stimulus#GO:0050896;leukocyte migration#GO:0050900;positive regulation of leukocyte proliferation#GO:0070665;leukocyte chemotaxis#GO:0030595;response to external stimulus#GO:0009605;immune response#GO:0006955;positive regulation of cellular process#GO:0048522;positive regulation of cell activation#GO:0050867;biological regulation#GO:0065007;cell migration#GO:0016477;multicellular organismal process#GO:0032501;regulation of lymphocyte proliferation#GO:0050670;cell activation#GO:0001775;positive regulation of lymphocyte proliferation#GO:0050671;chemotaxis#GO:0006935;cell chemotaxis#GO:0060326;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;positive regulation of lymphocyte activation#GO:0051251;cellular response to stimulus#GO:0051716;leukocyte activation#GO:0045321;locomotion#GO:0040011;positive regulation of B cell proliferation#GO:0030890;cell motility#GO:0048870;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021 HUMAN|HGNC=726|UniProtKB=Q93070 Q93070 ART4 PTHR10339:SF1 ADP-RIBOSYLTRANSFERASE ECTO-ADP-RIBOSYLTRANSFERASE 4 NAD+ poly-ADP-ribosyltransferase activity#GO:0003950;catalytic activity#GO:0003824;transferase activity#GO:0016740;pentosyltransferase activity#GO:0016763;glycosyltransferase activity#GO:0016757 transferase#PC00220 HUMAN|HGNC=33906|UniProtKB=Q075Z2 Q075Z2 BSPH1 PTHR22918:SF4 SEMINAL PLASMA PROTEIN BINDER OF SPERM PROTEIN HOMOLOG 1 spermatid differentiation#GO:0048515;sexual reproduction#GO:0019953;spermatid development#GO:0007286;anatomical structure development#GO:0048856;multicellular organismal reproductive process#GO:0048609;developmental process involved in reproduction#GO:0003006;anatomical structure maturation#GO:0071695;germ cell development#GO:0007281;cell differentiation#GO:0030154;gamete generation#GO:0007276;cellular process involved in reproduction in multicellular organism#GO:0022412;cell development#GO:0048468;reproductive process#GO:0022414;spermatogenesis#GO:0007283;developmental process#GO:0032502;cell maturation#GO:0048469;cellular developmental process#GO:0048869;cellular process#GO:0009987;developmental maturation#GO:0021700;male gamete generation#GO:0048232;sperm capacitation#GO:0048240 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=9561|UniProtKB=P55036 P55036 PSMD4 PTHR10223:SF7 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4 modification-dependent protein binding#GO:0140030;polyubiquitin modification-dependent protein binding#GO:0031593;binding#GO:0005488;protein binding#GO:0005515 ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238 intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;endopeptidase complex#GO:1905369;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;peptidase complex#GO:1905368;proteasome complex#GO:0000502;nucleus#GO:0005634 protease#PC00190;protein modifying enzyme#PC00260 Ubiquitin proteasome pathway#P00060>26S proteasome#P01489;Cell cycle#P00013>Proteasome#P00480 HUMAN|HGNC=11076|UniProtKB=Q15599 Q15599 NHERF2 PTHR14191:SF4 PDZ DOMAIN CONTAINING PROTEIN NA(+)_H(+) EXCHANGE REGULATORY COFACTOR NHE-RF2 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;signaling receptor binding#GO:0005102;binding#GO:0005488;protein-membrane adaptor activity#GO:0043495;protein binding#GO:0005515 cellular process#GO:0009987;macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657;protein localization to plasma membrane#GO:0072659;localization within membrane#GO:0051668;protein localization to cell periphery#GO:1990778;intracellular protein localization#GO:0008104;localization#GO:0051179;cellular localization#GO:0051641 apical part of cell#GO:0045177;cell periphery#GO:0071944;apical plasma membrane#GO:0016324;membrane#GO:0016020;plasma membrane#GO:0005886;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=3043|UniProtKB=O95456 O95456 PSMG1 PTHR15069:SF1 PROTEASOME ASSEMBLY CHAPERONE 1 PROTEASOME ASSEMBLY CHAPERONE 1 protein-containing complex binding#GO:0044877;binding#GO:0005488 chaperone-mediated protein complex assembly#GO:0051131;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;cellular component assembly#GO:0022607 intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;protein folding chaperone complex#GO:0101031;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cytosol#GO:0005829;nucleus#GO:0005634 chaperone#PC00072 HUMAN|HGNC=25129|UniProtKB=Q8IW92 Q8IW92 GLB1L2 PTHR23421:SF53 BETA-GALACTOSIDASE RELATED BETA-GALACTOSIDASE-1-LIKE PROTEIN 2 hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 carbohydrate catabolic process#GO:0016052;monosaccharide metabolic process#GO:0005996;metabolic process#GO:0008152;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;small molecule catabolic process#GO:0044282;carbohydrate metabolic process#GO:0005975;hexose metabolic process#GO:0019318;primary metabolic process#GO:0044238;cellular process#GO:0009987 galactosidase#PC00104;hydrolase#PC00121 HUMAN|HGNC=19074|UniProtKB=Q13769 Q13769 THOC5 PTHR13375:SF3 FMS INTERACTING PROTEIN THO COMPLEX SUBUNIT 5 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;transport#GO:0006810;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;metabolic process#GO:0008152;biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;establishment of localization in cell#GO:0051649;nitrogen compound transport#GO:0071705;macromolecule localization#GO:0033036;nuclear export#GO:0051168;nuclear transport#GO:0051169;nucleic acid transport#GO:0050657;mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;localization#GO:0051179;nucleocytoplasmic transport#GO:0006913;establishment of RNA localization#GO:0051236;mRNA transport#GO:0051028;RNA transport#GO:0050658;RNA localization#GO:0006403;nucleobase-containing compound transport#GO:0015931 THO complex#GO:0000347;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;transcription export complex#GO:0000346;intracellular organelle#GO:0043229 HUMAN|HGNC=19077|UniProtKB=O14931 O14931 NCR3 PTHR47904:SF1 NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 3 NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 3 response to stimulus#GO:0050896;signaling#GO:0023052;regulation of biological process#GO:0050789;immune response-regulating signaling pathway#GO:0002764;regulation of lymphocyte mediated immunity#GO:0002706;immune system process#GO:0002376;regulation of cell killing#GO:0031341;lymphocyte activation#GO:0046649;regulation of response to external stimulus#GO:0032101;positive regulation of immune system process#GO:0002684;activation of immune response#GO:0002253;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;immune response-activating signaling pathway#GO:0002757;positive regulation of response to external stimulus#GO:0032103;cell surface receptor signaling pathway#GO:0007166;natural killer cell activation#GO:0030101;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of response to biotic stimulus#GO:0002831;immune response-activating cell surface receptor signaling pathway#GO:0002429;positive regulation of natural killer cell mediated immunity#GO:0002717;leukocyte activation#GO:0045321;regulation of leukocyte mediated immunity#GO:0002703;regulation of natural killer cell mediated immunity#GO:0002715;cellular response to stimulus#GO:0051716;positive regulation of lymphocyte mediated immunity#GO:0002708;cell communication#GO:0007154;regulation of immune effector process#GO:0002697;regulation of leukocyte mediated cytotoxicity#GO:0001910;regulation of immune response#GO:0050776;regulation of defense response#GO:0031347;cell activation#GO:0001775;positive regulation of response to stimulus#GO:0048584;regulation of natural killer cell mediated cytotoxicity#GO:0042269;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;positive regulation of immune effector process#GO:0002699;positive regulation of natural killer cell mediated cytotoxicity#GO:0045954;positive regulation of cellular process#GO:0048522;positive regulation of innate immune response#GO:0045089;regulation of innate immune response#GO:0045088;positive regulation of response to biotic stimulus#GO:0002833;positive regulation of leukocyte mediated immunity#GO:0002705;regulation of response to stress#GO:0080134;positive regulation of defense response#GO:0031349;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583 HUMAN|HGNC=11768|UniProtKB=P61812 P61812 TGFB2 PTHR11848:SF141 TGF-BETA FAMILY TRANSFORMING GROWTH FACTOR BETA-2 PROPROTEIN molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;receptor ligand activity#GO:0048018;cytokine activity#GO:0005125;signaling receptor regulator activity#GO:0030545 response to transforming growth factor beta#GO:0071559;animal gross anatomical part developmental process#GO:0160108;cellular response to growth factor stimulus#GO:0071363;system development#GO:0048731;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;cellular response to stimulus#GO:0051716;cellular response to transforming growth factor beta stimulus#GO:0071560;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;signaling#GO:0023052;regulation of cellular process#GO:0050794;cellular response to endogenous stimulus#GO:0071495;circulatory system development#GO:0072359;response to growth factor#GO:0070848;response to stimulus#GO:0050896;cell surface receptor signaling pathway#GO:0007166;developmental process#GO:0032502;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;animal organ development#GO:0048513;multicellular organism development#GO:0007275;cellular process#GO:0009987;signal transduction#GO:0007165;transforming growth factor beta receptor signaling pathway#GO:0007179;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;heart development#GO:0007507;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 growth factor#PC00112 TGF-beta signaling pathway#P00052>TGFbeta#P01286;Gonadotropin-releasing hormone receptor pathway#P06664>TGFbeta#P06778 HUMAN|HGNC=25724|UniProtKB=Q9H9V9 Q9H9V9 JMJD4 PTHR12480:SF6 ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD 2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE JMJD4 DNA binding#GO:0003677;dioxygenase activity#GO:0051213;binding#GO:0005488;nucleic acid binding#GO:0003676;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;oxidoreductase activity#GO:0016491;sequence-specific DNA binding#GO:0043565;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705 positive regulation of cellular component organization#GO:0051130;positive regulation of protein metabolic process#GO:0051247;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of translation#GO:0045727;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;post-transcriptional regulation of gene expression#GO:0010608;regulation of biosynthetic process#GO:0009889;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;regulation of protein-containing complex disassembly#GO:0043244;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604;biological regulation#GO:0065007 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 protein modifying enzyme#PC00260 HUMAN|HGNC=2726|UniProtKB=P35638 P35638 DDIT3 PTHR16833:SF0 DNA DAMAGE-INDUCIBLE TRANSCRIPT 3 DDIT3 DNA DAMAGE-INDUCIBLE TRANSCRIPT 3 PROTEIN DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;sequence-specific DNA binding#GO:0043565;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription activator activity#GO:0001216;transcription regulator activity#GO:0140110;protein binding#GO:0005515;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of DNA-templated transcription#GO:0006355;cell communication#GO:0007154;regulation of RNA metabolic process#GO:0051252;intracellular signal transduction#GO:0035556;negative regulation of transcription by RNA polymerase II#GO:0000122;response to endoplasmic reticulum stress#GO:0034976;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;cellular response to biotic stimulus#GO:0071216;programmed cell death#GO:0012501;cellular response to stimulus#GO:0051716;cell death#GO:0008219;apoptotic signaling pathway#GO:0097190;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;intrinsic apoptotic signaling pathway#GO:0097193;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;cellular response to stress#GO:0033554;intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress#GO:0070059;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;negative regulation of metabolic process#GO:0009892;signaling#GO:0023052;negative regulation of biological process#GO:0048519;apoptotic process#GO:0006915;regulation of biological process#GO:0050789;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;response to stress#GO:0006950;negative regulation of macromolecule biosynthetic process#GO:0010558;response to biotic stimulus#GO:0009607;cellular process#GO:0009987;signal transduction#GO:0007165 nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;nuclear protein-containing complex#GO:0140513 Oxidative stress response#P00046>CHOP#P01130 HUMAN|HGNC=11497|UniProtKB=Q96PV0 Q96PV0 SYNGAP1 PTHR10194:SF25 RAS GTPASE-ACTIVATING PROTEINS RAS_RAP GTPASE-ACTIVATING PROTEIN SYNGAP GTPase-activating protein#PC00257 HUMAN|HGNC=664|UniProtKB=P78540 P78540 ARG2 PTHR43782:SF4 ARGINASE ARGINASE-2, MITOCHONDRIAL hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;catalytic activity#GO:0003824;cation binding#GO:0043169;metal ion binding#GO:0046872;hydrolase activity#GO:0016787;transition metal ion binding#GO:0046914;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cytokine production#GO:0001817;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;amino acid metabolic process#GO:0006520;arginine metabolic process#GO:0006525;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;biosynthetic process#GO:0009058;negative regulation of cellular process#GO:0048523;metabolic process#GO:0008152;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;negative regulation of multicellular organismal process#GO:0051241;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;small molecule metabolic process#GO:0044281;regulation of macromolecule metabolic process#GO:0060255;negative regulation of metabolic process#GO:0009892;oxoacid metabolic process#GO:0043436 mitochondrion#GO:0005739;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HUMAN|HGNC=3959|UniProtKB=Q92765 Q92765 FRZB PTHR11309:SF97 FRIZZLED SECRETED FRIZZLED-RELATED PROTEIN 3 transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488;signaling receptor activity#GO:0038023;Wnt-protein binding#GO:0017147;molecular transducer activity#GO:0060089;protein binding#GO:0005515 cell communication#GO:0007154;canonical Wnt signaling pathway#GO:0060070;cell surface receptor signaling pathway#GO:0007166;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;Wnt signaling pathway#GO:0016055;biological regulation#GO:0065007;signaling#GO:0023052;non-canonical Wnt signaling pathway#GO:0035567;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;extracellular region#GO:0005576 transmembrane signal receptor#PC00197 Wnt signaling pathway#P00057>FrzB#P01461;Angiogenesis#P00005>FRP#P00237 HUMAN|HGNC=8864|UniProtKB=P27918 P27918 CFP PTHR22906:SF43 PROPERDIN PROPERDIN HUMAN|HGNC=3439|UniProtKB=Q13216 Q13216 ERCC8 PTHR46202:SF1 DNA EXCISION REPAIR PROTEIN ERCC-8 DNA EXCISION REPAIR PROTEIN ERCC-8 enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 response to stress#GO:0006950;cellular process#GO:0009987;post-translational protein modification#GO:0043687;proteasomal protein catabolic process#GO:0010498;protein ubiquitination#GO:0016567;nucleobase-containing compound metabolic process#GO:0006139;nucleotide-excision repair#GO:0006289;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;nucleic acid metabolic process#GO:0090304;protein modification process#GO:0036211;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;modification-dependent protein catabolic process#GO:0019941;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;catabolic process#GO:0009056;response to stimulus#GO:0050896;protein modification by small protein conjugation or removal#GO:0070647;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cullin-RING ubiquitin ligase complex#GO:0031461;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ubiquitin ligase complex#GO:0000151;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;protein-containing complex#GO:0032991;Cul4-RING E3 ubiquitin ligase complex#GO:0080008;transferase complex#GO:1990234;nucleotide-excision repair complex#GO:0000109;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535 DNA metabolism protein#PC00009 HUMAN|HGNC=85|UniProtKB=O00763 O00763 ACACB PTHR45728:SF1 ACETYL-COA CARBOXYLASE, ISOFORM A ACETYL-COA CARBOXYLASE 2 ligase activity#GO:0016874;catalytic activity#GO:0003824 fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;monocarboxylic acid biosynthetic process#GO:0072330;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;monocarboxylic acid metabolic process#GO:0032787;cellular process#GO:0009987;carboxylic acid biosynthetic process#GO:0046394;lipid biosynthetic process#GO:0008610;small molecule metabolic process#GO:0044281;biosynthetic process#GO:0009058;fatty acid biosynthetic process#GO:0006633 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739 HUMAN|HGNC=9797|UniProtKB=P47224 P47224 RABIF PTHR13276:SF0 GUANINE NUCLEOTIDE EXCHANGE FACTOR MSS4 GUANINE NUCLEOTIDE EXCHANGE FACTOR MSS4 guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234 transport#GO:0006810;Golgi vesicle transport#GO:0048193;cellular process#GO:0009987;post-Golgi vesicle-mediated transport#GO:0006892;vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;localization#GO:0051179 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;membrane#GO:0016020 guanyl-nucleotide exchange factor#PC00113;protein-binding activity modulator#PC00095 HUMAN|HGNC=12638|UniProtKB=O14607 O14607 UTY PTHR14017:SF25 LYSINE-SPECIFIC DEMETHYLASE HISTONE DEMETHYLASE UTY sequence-specific DNA binding#GO:0043565;demethylase activity#GO:0032451;protein demethylase activity#GO:0140457;histone demethylase activity#GO:0032452;histone modifying activity#GO:0140993;transcription regulatory region nucleic acid binding#GO:0001067;binding#GO:0005488;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;catalytic activity, acting on a protein#GO:0140096;sequence-specific double-stranded DNA binding#GO:1990837;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;chromatin DNA binding#GO:0031490;catalytic activity#GO:0003824;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;dioxygenase activity#GO:0051213;chromatin binding#GO:0003682;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;circulatory system development#GO:0072359;regulation of biological process#GO:0050789;system development#GO:0048731;anatomical structure development#GO:0048856;animal gross anatomical part developmental process#GO:0160108;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;heart development#GO:0007507;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;animal organ development#GO:0048513;regulation of biosynthetic process#GO:0009889;multicellular organism development#GO:0007275;developmental process#GO:0032502 histone methyltransferase complex#GO:0035097;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;methyltransferase complex#GO:0034708;nucleoplasm#GO:0005654 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=10021|UniProtKB=Q9Y572 Q9Y572 RIPK3 PTHR23257:SF974 SERINE-THREONINE PROTEIN KINASE RECEPTOR-INTERACTING SERINE_THREONINE-PROTEIN KINASE 3 transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=21661|UniProtKB=Q5SSG8 Q5SSG8 MUC21 PTHR39408:SF4 MUCIN-21 MUCIN-21 negative regulation of cellular process#GO:0048523;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cell adhesion#GO:0030155;regulation of cell-cell adhesion#GO:0022407;regulation of cellular process#GO:0050794;negative regulation of cell adhesion#GO:0007162;negative regulation of cell-cell adhesion#GO:0022408;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HUMAN|HGNC=24931|UniProtKB=Q9NQZ6 Q9NQZ6 ZC4H2 PTHR31058:SF2 ZINC FINGER C4H2 DOMAIN-CONTAINING PROTEIN ZINC FINGER C4H2 DOMAIN-CONTAINING PROTEIN positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of neuron differentiation#GO:0045664;multicellular organismal process#GO:0032501;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of developmental process#GO:0051094;developmental process#GO:0032502;regulation of cell differentiation#GO:0045595;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of developmental process#GO:0050793;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;positive regulation of biological process#GO:0048518;nervous system development#GO:0007399;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of cell differentiation#GO:0045597;positive regulation of transcription by RNA polymerase II#GO:0045944;multicellular organism development#GO:0007275;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;animal gross anatomical part developmental process#GO:0160108;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=10882|UniProtKB=P81133 P81133 SIM1 PTHR23043:SF22 HYPOXIA-INDUCIBLE FACTOR 1 ALPHA SINGLE-MINDED HOMOLOG 1 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=15943|UniProtKB=Q9NPB6 Q9NPB6 PARD6A PTHR14102:SF9 PAR-6-RELATED PARTITIONING DEFECTIVE 6 HOMOLOG ALPHA protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 cellular component organization#GO:0016043;organelle organization#GO:0006996;cell cycle#GO:0007049;cell cycle process#GO:0022402;cellular process#GO:0009987;centrosome cycle#GO:0007098;cell junction organization#GO:0034330;cytoskeleton organization#GO:0007010;establishment or maintenance of cell polarity#GO:0007163;cell-cell junction organization#GO:0045216;microtubule cytoskeleton organization#GO:0000226;cell-cell junction maintenance#GO:0045217;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;microtubule organizing center organization#GO:0031023 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;cell cortex#GO:0005938;apical plasma membrane#GO:0016324;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;apical part of cell#GO:0045177;transferase complex#GO:1990234;protein kinase complex#GO:1902911;cell periphery#GO:0071944;nucleus#GO:0005634;membrane#GO:0016020;cytoplasm#GO:0005737;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;plasma membrane region#GO:0098590 cell junction protein#PC00070;tight junction#PC00214 HUMAN|HGNC=31421|UniProtKB=Q5VZ72 Q5VZ72 IZUMO3 PTHR36470:SF1 IZUMO SPERM-EGG FUSION PROTEIN 3 IZUMO SPERM-EGG FUSION PROTEIN 3 HUMAN|HGNC=29241|UniProtKB=Q9H0H0 Q9H0H0 INTS2 PTHR28608:SF1 INTEGRATOR COMPLEX SUBUNIT 2 INTEGRATOR COMPLEX SUBUNIT 2 macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;snRNA processing#GO:0016180;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule catabolic process#GO:0009057;transcription by RNA polymerase II#GO:0006366;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;transcription initiation at RNA polymerase II promoter#GO:0006367;nucleobase-containing compound catabolic process#GO:0034655;nucleic acid catabolic process#GO:0141188;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;snRNA metabolic process#GO:0016073;RNA metabolic process#GO:0016070;RNA catabolic process#GO:0006401;nucleic acid biosynthetic process#GO:0141187;catabolic process#GO:0009056;DNA-templated transcription initiation#GO:0006352;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;snRNA 3'-end processing#GO:0034472;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 integrator complex#GO:0032039;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226 HUMAN|HGNC=28072|UniProtKB=Q5U5X0 Q5U5X0 LYRM7 PTHR46749:SF1 COMPLEX III ASSEMBLY FACTOR LYRM7 COMPLEX III ASSEMBLY FACTOR LYRM7 protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;cytochrome complex assembly#GO:0017004;mitochondrial respiratory chain complex assembly#GO:0033108;mitochondrial respiratory chain complex III assembly#GO:0034551;mitochondrion organization#GO:0007005;cellular component assembly#GO:0022607;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular component organization#GO:0016043 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HUMAN|HGNC=26552|UniProtKB=Q8N5R6 Q8N5R6 CCDC33 PTHR21623:SF2 SPERIOLIN-BINDING FACTOR COILED-COIL DOMAIN-CONTAINING PROTEIN 33 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;microbody#GO:0042579;peroxisome#GO:0005777 HUMAN|HGNC=7901|UniProtKB=O15130 O15130 NPFF PTHR15044:SF0 NEUROPEPTIDE FF PRO-FMRFAMIDE-RELATED NEUROPEPTIDE FF signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;hormone activity#GO:0005179;neuropeptide hormone activity#GO:0005184;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;positive regulation of blood pressure#GO:0045777;signaling#GO:0023052;G protein-coupled receptor signaling pathway#GO:0007186;immune system process#GO:0002376;nervous system process#GO:0050877;regulation of biological quality#GO:0065008;synaptic signaling#GO:0099536;response to stress#GO:0006950;cellular process#GO:0009987;signal transduction#GO:0007165;cell surface receptor signaling pathway#GO:0007166;regulation of membrane potential#GO:0042391;neuropeptide signaling pathway#GO:0007218;chemical synaptic transmission#GO:0007268;cellular response to stimulus#GO:0051716;regulation of postsynaptic membrane potential#GO:0060078;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;chemical synaptic transmission, postsynaptic#GO:0099565;circulatory system process#GO:0003013;trans-synaptic signaling#GO:0099537;inflammatory response#GO:0006954;cell communication#GO:0007154;acute inflammatory response#GO:0002526;regulation of blood pressure#GO:0008217;immune response#GO:0006955;multicellular organismal process#GO:0032501;blood circulation#GO:0008015;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;defense response#GO:0006952;system process#GO:0003008 dendrite#GO:0030425;axon#GO:0030424;dendritic tree#GO:0097447;extracellular region#GO:0005576;cell junction#GO:0030054;axon terminus#GO:0043679;presynapse#GO:0098793;neuron projection#GO:0043005;synapse#GO:0045202;cellular anatomical structure#GO:0110165;neuron projection terminus#GO:0044306;somatodendritic compartment#GO:0036477;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;distal axon#GO:0150034 HUMAN|HGNC=5527|UniProtKB=P01860 P01860 IGHG3 PTHR23411:SF38 TAPASIN IMMUNOGLOBULIN HEAVY CONSTANT GAMMA 3 protein binding#GO:0005515;antigen binding#GO:0003823;binding#GO:0005488;signaling receptor binding#GO:0005102 positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;response to external stimulus#GO:0009605;defense response#GO:0006952;immune response#GO:0006955;complement activation#GO:0006956;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;adaptive immune response#GO:0002250;response to other organism#GO:0051707;response to bacterium#GO:0009617;regulation of immune response#GO:0050776;regulation of immune system process#GO:0002682;response to external biotic stimulus#GO:0043207;humoral immune response#GO:0006959;antimicrobial humoral response#GO:0019730;immune effector process#GO:0002252;antibacterial humoral response#GO:0019731;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;positive regulation of immune system process#GO:0002684;defense response to symbiont#GO:0140546;activation of immune response#GO:0002253;positive regulation of biological process#GO:0048518;defense response to other organism#GO:0098542;immune system process#GO:0002376;defense response to bacterium#GO:0042742;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;immunoglobulin mediated immune response#GO:0016064;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;extracellular region#GO:0005576;extracellular protein-containing complex#GO:0140392 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=1967|UniProtKB=P07510 P07510 CHRNG PTHR18945:SF60 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR SUBUNIT GAMMA ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;monoatomic cation channel activity#GO:0005261;ligand-gated monoatomic ion channel activity#GO:0015276;molecular transducer activity#GO:0060089;channel activity#GO:0015267;neurotransmitter receptor activity#GO:0030594;transporter activity#GO:0005215;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;signaling receptor activity#GO:0038023;gated channel activity#GO:0022836;postsynaptic neurotransmitter receptor activity#GO:0098960;monoatomic cation transmembrane transporter activity#GO:0008324 transport#GO:0006810;muscle contraction#GO:0006936;establishment of localization#GO:0051234;system process#GO:0003008;cellular response to nitrogen compound#GO:1901699;acetylcholine receptor signaling pathway#GO:0095500;multicellular organismal process#GO:0032501;synaptic transmission, cholinergic#GO:0007271;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;trans-synaptic signaling#GO:0099537;neuromuscular process#GO:0050905;monoatomic cation transport#GO:0006812;cell communication#GO:0007154;localization#GO:0051179;response to nitrogen compound#GO:1901698;chemical synaptic transmission#GO:0007268;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;striated muscle contraction#GO:0006941;membrane depolarization#GO:0051899;metal ion transport#GO:0030001;regulation of membrane potential#GO:0042391;calcium ion transport#GO:0006816;synaptic signaling#GO:0099536;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;response to chemical#GO:0042221;cellular response to chemical stimulus#GO:0070887;nervous system process#GO:0050877;response to oxygen-containing compound#GO:1901700;transmembrane transport#GO:0055085;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;muscle system process#GO:0003012;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;skeletal muscle contraction#GO:0003009;signaling#GO:0023052 cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;postsynapse#GO:0098794;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;transmembrane transporter complex#GO:1902495;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane region#GO:0098590;postsynaptic specialization#GO:0099572;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;transporter complex#GO:1990351;cell junction#GO:0030054;synaptic membrane#GO:0097060;signaling receptor complex#GO:0043235 ligand-gated ion channel#PC00141 Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086;Nicotinic acetylcholine receptor signaling pathway#P00044>gamma#P01094 HUMAN|HGNC=3235|UniProtKB=Q8IUX8 Q8IUX8 EGFL6 PTHR24050:SF24 PA14 DOMAIN-CONTAINING PROTEIN EPIDERMAL GROWTH FACTOR-LIKE PROTEIN 6 HUMAN|HGNC=28034|UniProtKB=Q5EBL8 Q5EBL8 PDZD11 PTHR14063:SF1 PROTEIN LIN-7 HOMOLOG PDZ DOMAIN-CONTAINING PROTEIN 11 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;establishment of vesicle localization#GO:0051650;neurotransmitter transport#GO:0006836;cellular component assembly#GO:0022607;synaptic vesicle localization#GO:0097479;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;synaptic signaling#GO:0099536;synaptic vesicle transport#GO:0048489;secretion by cell#GO:0032940;regulation of biological quality#GO:0065008;cellular localization#GO:0051641;regulation of synapse organization#GO:0050807;signaling#GO:0023052;export from cell#GO:0140352;regulation of cellular component biogenesis#GO:0044087;regulation of cellular component organization#GO:0051128;establishment of organelle localization#GO:0051656;regulation of biological process#GO:0050789;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;establishment of localization#GO:0051234;transport#GO:0006810;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;neurotransmitter secretion#GO:0007269;regulation of synapse assembly#GO:0051963;vesicle localization#GO:0051648;localization#GO:0051179;cell communication#GO:0007154;secretion#GO:0046903;regulation of synapse structure or activity#GO:0050803;regulation of cell junction assembly#GO:1901888;signal release#GO:0023061;trans-synaptic signaling#GO:0099537;organelle localization#GO:0051640;regulation of developmental process#GO:0050793;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;regulation of growth#GO:0040008;signal release from synapse#GO:0099643;chemical synaptic transmission#GO:0007268 cell-cell junction#GO:0005911;membrane#GO:0016020;basolateral plasma membrane#GO:0016323;basal part of cell#GO:0045178;cell periphery#GO:0071944;basal plasma membrane#GO:0009925;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;plasma membrane#GO:0005886;cell junction#GO:0030054;anchoring junction#GO:0070161 cell junction protein#PC00070 HUMAN|HGNC=2705|UniProtKB=P07585 P07585 DCN PTHR45712:SF14 AGAP008170-PA DECORIN cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=2989|UniProtKB=Q8IZD9 Q8IZD9 DOCK3 PTHR45653:SF4 DEDICATOR OF CYTOKINESIS DEDICATOR OF CYTOKINESIS PROTEIN 3 protein binding#GO:0005515;small GTPase binding#GO:0031267;enzyme regulator activity#GO:0030234;guanyl-nucleotide exchange factor activity#GO:0005085;binding#GO:0005488;enzyme binding#GO:0019899;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein modulator#PC00022;protein-binding activity modulator#PC00095;guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=2001|UniProtKB=O60565 O60565 GREM1 PTHR15283:SF3 GREMLIN 1 GREMLIN-1 binding#GO:0005488;protein binding#GO:0005515;molecular function activator activity#GO:0140677;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;cytokine binding#GO:0019955;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=4500|UniProtKB=O15529 O15529 GPR42 PTHR45822:SF6 FREE FATTY ACID RECEPTOR 2-RELATED FREE FATTY ACID RECEPTOR 3-RELATED transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930 cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;response to chemical#GO:0042221;response to lipid#GO:0033993;cellular response to lipid#GO:0071396;response to oxygen-containing compound#GO:1901700;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;response to fatty acid#GO:0070542;cell communication#GO:0007154;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular response to fatty acid#GO:0071398;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HUMAN|HGNC=4367|UniProtKB=P17900 P17900 GM2A PTHR17357:SF0 GM2 GANGLIOSIDE ACTIVATOR PROTEIN GANGLIOSIDE GM2 ACTIVATOR lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104 carbohydrate derivative catabolic process#GO:1901136;liposaccharide metabolic process#GO:1903509;catabolic process#GO:0009056;glycolipid metabolic process#GO:0006664;primary metabolic process#GO:0044238;sphingolipid catabolic process#GO:0030149;localization#GO:0051179;ceramide metabolic process#GO:0006672;lipid localization#GO:0010876;lipid transport#GO:0006869;carbohydrate derivative metabolic process#GO:1901135;lipid catabolic process#GO:0016042;cellular process#GO:0009987;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;lipid metabolic process#GO:0006629;transport#GO:0006810;metabolic process#GO:0008152;sphingolipid metabolic process#GO:0006665 side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cytoplasmic side of plasma membrane#GO:0009898;membrane#GO:0016020;cytoplasmic side of membrane#GO:0098562;cell periphery#GO:0071944 transfer/carrier protein#PC00219 HUMAN|HGNC=10879|UniProtKB=Q15468 Q15468 STIL PTHR15128:SF0 TAL1 SCL INTERRUPTING LOCUS SCL-INTERRUPTING LOCUS PROTEIN macromolecule localization#GO:0033036;protein localization to microtubule cytoskeleton#GO:0072698;biological regulation#GO:0065007;spindle organization#GO:0007051;intracellular protein localization#GO:0008104;mitotic cell cycle process#GO:1903047;cell cycle#GO:0007049;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cellular response to stimulus#GO:0051716;protein localization to centrosome#GO:0071539;mitotic cell cycle#GO:0000278;protein localization to organelle#GO:0033365;regulation of cellular process#GO:0050794;cell communication#GO:0007154;localization#GO:0051179;microtubule cytoskeleton organization#GO:0000226;smoothened signaling pathway#GO:0007224;organelle organization#GO:0006996;signal transduction#GO:0007165;cellular process#GO:0009987;cytoskeleton organization#GO:0007010;cell surface receptor signaling pathway#GO:0007166;cellular component organization or biogenesis#GO:0071840;microtubule organizing center organization#GO:0031023;microtubule-based process#GO:0007017;protein localization to cytoskeleton#GO:0044380;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;cell cycle process#GO:0022402;response to stimulus#GO:0050896;mitotic spindle organization#GO:0007052;signaling#GO:0023052;protein localization to microtubule organizing center#GO:1905508 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=30339|UniProtKB=O15034 O15034 RIMBP2 PTHR14234:SF18 RIM BINDING PROTEIN-RELATED RIMS-BINDING PROTEIN 2 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 regulation of transport#GO:0051049;regulation of localization#GO:0032879;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of organelle organization#GO:0033043;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789 cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;synapse#GO:0045202;glutamatergic synapse#GO:0098978;cell cortex#GO:0005938;presynapse#GO:0098793;cell periphery#GO:0071944;intracellular anatomical structure#GO:0005622;cell junction#GO:0030054;presynaptic active zone#GO:0048786 scaffold/adaptor protein#PC00226 HUMAN|HGNC=3796|UniProtKB=P01100 P01100 FOS PTHR23351:SF4 FOS TRANSCRIPTION FACTOR-RELATED PROTEIN C-FOS cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 basic leucine zipper transcription factor#PC00056 Gonadotropin-releasing hormone receptor pathway#P06664>c-fos#G06680;Apoptosis signaling pathway#P00006>Fos#P00317;B cell activation#P00010>fos#P00380;Interleukin signaling pathway#P00036>c-fos#P00967;Gonadotropin-releasing hormone receptor pathway#P06664>c-fos#G06894;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>c-fos#P00884;CCKR signaling map#P06959>FOS#G06973;CCKR signaling map#P06959>FOS#G07266;T cell activation#P00053>fos#P01309;CCKR signaling map#P06959>FOS#P07035;Gonadotropin-releasing hormone receptor pathway#P06664>FOS#P06709;Angiogenesis#P00005>c-Fos#P00235;Huntington disease#P00029>Fos protein#P00801;PDGF signaling pathway#P00047>c-fos#P01145 HUMAN|HGNC=19015|UniProtKB=Q96BQ3 Q96BQ3 TRIM43 PTHR24103:SF705 E3 UBIQUITIN-PROTEIN LIGASE TRIM TRIPARTITE MOTIF-CONTAINING PROTEIN 43 transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659 regulation of biosynthetic process#GO:0009889;innate immune response#GO:0045087;defense response#GO:0006952;regulation of gene expression#GO:0010468;response to external stimulus#GO:0009605;response to stress#GO:0006950;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;response to biotic stimulus#GO:0009607;immune response#GO:0006955;defense response to symbiont#GO:0140546;defense response to other organism#GO:0098542;response to other organism#GO:0051707;biological regulation#GO:0065007;immune system process#GO:0002376;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=11524|UniProtKB=Q9Y6A5 Q9Y6A5 TACC3 PTHR13924:SF4 TRANSFORMING ACIDIC COILED-COIL CONTAINING PROTEIN 1/2 TRANSFORMING ACIDIC COILED-COIL-CONTAINING PROTEIN 3 cytoplasmic microtubule organization#GO:0031122;establishment of organelle localization#GO:0051656;cell differentiation#GO:0030154;cell cycle process#GO:0022402;nuclear migration#GO:0007097;cellular component organization#GO:0016043;cell cycle#GO:0007049;supramolecular fiber organization#GO:0097435;system development#GO:0048731;microtubule cytoskeleton organization#GO:0000226;cellular localization#GO:0051641;anatomical structure development#GO:0048856;localization#GO:0051179;animal gross anatomical part developmental process#GO:0160108;organelle localization#GO:0051640;nervous system development#GO:0007399;cytoskeleton organization#GO:0007010;multicellular organismal process#GO:0032501;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;organelle organization#GO:0006996;neurogenesis#GO:0022008;microtubule-based process#GO:0007017;cellular developmental process#GO:0048869;establishment of localization#GO:0051234;spindle organization#GO:0007051;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;transport#GO:0006810;developmental process#GO:0032502;intracellular transport#GO:0046907 spindle pole#GO:0000922;cytosol#GO:0005829;microtubule cytoskeleton#GO:0015630;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule organizing center#GO:0005815;centrosome#GO:0005813;spindle#GO:0005819;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=2940|UniProtKB=Q9P2D7 Q9P2D7 DNAH1 PTHR10676:SF402 DYNEIN HEAVY CHAIN FAMILY PROTEIN DYNEIN AXONEMAL HEAVY CHAIN 1 ATP-dependent activity#GO:0140657;binding#GO:0005488;polypeptide conformation or assembly isomerase activity#GO:0120544;microtubule motor activity#GO:0003777;protein binding#GO:0005515;macromolecular conformation isomerase activity#GO:0120543;catalytic activity#GO:0003824;isomerase activity#GO:0016853;cytoskeletal motor activity#GO:0003774 reproductive process#GO:0022414;cell motility#GO:0048870;microtubule-based movement#GO:0007018;cellular process#GO:0009987;sperm motility#GO:0097722;cilium movement involved in cell motility#GO:0060294;microtubule-based process#GO:0007017;cilium-dependent cell motility#GO:0060285;cilium or flagellum-dependent cell motility#GO:0001539;cilium movement#GO:0003341;flagellated sperm motility#GO:0030317 membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;microtubule associated complex#GO:0005875;sperm flagellum#GO:0036126;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;9+2 motile cilium#GO:0097729;cilium#GO:0005929;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;motile cilium#GO:0031514;dynein complex#GO:0030286 microtubule or microtubule-binding cytoskeletal protein#PC00157;microtubule binding motor protein#PC00156 Huntington disease#P00029>Dynein complex#P00774 HUMAN|HGNC=5973|UniProtKB=P35225 P35225 IL13 PTHR48486:SF1 INTERLEUKIN-13 INTERLEUKIN-13 protein binding#GO:0005515;cytokine receptor binding#GO:0005126;signaling receptor binding#GO:0005102;binding#GO:0005488 inflammatory response#GO:0006954;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;regulation of immune effector process#GO:0002697;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;response to stimulus#GO:0050896;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;positive regulation of gene expression#GO:0010628;defense response#GO:0006952;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of immune system process#GO:0002684;regulation of metabolic process#GO:0019222;response to stress#GO:0006950;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;positive regulation of immune effector process#GO:0002699;positive regulation of macromolecule metabolic process#GO:0010604 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 Interleukin signaling pathway#P00036>Interleukin#P00970;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>IL2#P00870 HUMAN|HGNC=16126|UniProtKB=A1Z1Q3 A1Z1Q3 MACROD2 PTHR11106:SF104 GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED ADP-RIBOSE GLYCOHYDROLASE MACROD2 catalytic activity, acting on a protein#GO:0140096;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787;catalytic activity#GO:0003824 carbohydrate derivative metabolic process#GO:1901135;purine-containing compound metabolic process#GO:0072521;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stress#GO:0006950;primary metabolic process#GO:0044238;nucleobase-containing compound metabolic process#GO:0006139;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;nucleoside metabolic process#GO:0009116;DNA damage response#GO:0006974;cellular response to stress#GO:0033554;purine nucleoside metabolic process#GO:0042278;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 HUMAN|HGNC=29814|UniProtKB=Q96NY9 Q96NY9 MUS81 PTHR13451:SF0 CLASS II CROSSOVER JUNCTION ENDONUCLEASE MUS81 STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT MUS81 nuclease activity#GO:0004518;hydrolase activity#GO:0016787;DNA endonuclease activity#GO:0004520;endonuclease activity#GO:0004519;catalytic activity, acting on DNA#GO:0140097;hydrolase activity, acting on ester bonds#GO:0016788;DNA nuclease activity#GO:0004536;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640 meiosis I cell cycle process#GO:0061982;recombinational repair#GO:0000725;sexual reproduction#GO:0019953;cell communication#GO:0007154;organelle fission#GO:0048285;intracellular signal transduction#GO:0035556;cell cycle#GO:0007049;regulation of cell cycle phase transition#GO:1901987;mitotic cell cycle checkpoint signaling#GO:0007093;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;reciprocal homologous recombination#GO:0140527;mitotic DNA damage checkpoint signaling#GO:0044773;cellular response to stimulus#GO:0051716;mitotic cell cycle#GO:0000278;regulation of cellular process#GO:0050794;reproductive process#GO:0022414;homologous recombination#GO:0035825;DNA repair#GO:0006281;negative regulation of cellular process#GO:0048523;DNA damage response#GO:0006974;negative regulation of cell cycle process#GO:0010948;macromolecule metabolic process#GO:0043170;meiotic nuclear division#GO:0140013;mitotic cell cycle process#GO:1903047;DNA integrity checkpoint signaling#GO:0031570;double-strand break repair via break-induced replication#GO:0000727;resolution of meiotic recombination intermediates#GO:0000712;regulation of mitotic cell cycle#GO:0007346;mitotic DNA integrity checkpoint signaling#GO:0044774;DNA damage checkpoint signaling#GO:0000077;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;nuclear division#GO:0000280;cellular response to stress#GO:0033554;reciprocal meiotic recombination#GO:0007131;mitotic intra-S DNA damage checkpoint signaling#GO:0031573;negative regulation of mitotic cell cycle#GO:0045930;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;meiosis I#GO:0007127;negative regulation of cell cycle phase transition#GO:1901988;meiotic cell cycle process#GO:1903046;regulation of biological process#GO:0050789;signal transduction in response to DNA damage#GO:0042770;cell cycle process#GO:0022402;double-strand break repair via homologous recombination#GO:0000724;response to stimulus#GO:0050896;regulation of cell cycle#GO:0051726;signaling#GO:0023052;meiotic cell cycle#GO:0051321;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;DNA recombination#GO:0006310;cellular component organization or biogenesis#GO:0071840;negative regulation of cell cycle#GO:0045786;double-strand break repair#GO:0006302;organelle organization#GO:0006996;response to stress#GO:0006950;signal transduction#GO:0007165;cellular process#GO:0009987;cell cycle checkpoint signaling#GO:0000075;regulation of cell cycle process#GO:0010564 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;endonuclease complex#GO:1905348;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535 HUMAN|HGNC=25789|UniProtKB=Q7Z2Z2 Q7Z2Z2 EFL1 PTHR42908:SF3 TRANSLATION ELONGATION FACTOR-RELATED ELONGATION FACTOR-LIKE GTPASE 1 ribonucleoprotein complex binding#GO:0043021;hydrolase activity#GO:0016787;protein-containing complex binding#GO:0044877;ribosome binding#GO:0043022;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924;translation elongation factor activity#GO:0003746;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817;translation factor activity#GO:0180051 macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;translational elongation#GO:0006414;metabolic process#GO:0008152;gene expression#GO:0010467;cellular component assembly#GO:0022607;biosynthetic process#GO:0009058;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein metabolic process#GO:0019538;ribosome biogenesis#GO:0042254;ribosome assembly#GO:0042255;organelle assembly#GO:0070925;translation#GO:0006412;protein biosynthetic process#GO:0160307;ribonucleoprotein complex biogenesis#GO:0022613;membraneless organelle assembly#GO:0140694;primary metabolic process#GO:0044238;cellular component organization#GO:0016043 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytosol#GO:0005829;ribonucleoprotein complex#GO:1990904 translation elongation factor#PC00222 HUMAN|HGNC=2379|UniProtKB=O75718 O75718 CRTAP PTHR13986:SF3 PROTEIN LYSINE HYDROXYLATION COMPLEX COMPONENT CARTILAGE-ASSOCIATED PROTEIN protein-containing complex binding#GO:0044877;binding#GO:0005488;collagen binding#GO:0005518 extracellular matrix organization#GO:0030198;collagen fibril organization#GO:0030199;cellular component organization or biogenesis#GO:0071840;external encapsulating structure organization#GO:0045229;cellular component organization#GO:0016043;extracellular structure organization#GO:0043062;cellular process#GO:0009987 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 protein modifying enzyme#PC00260 HUMAN|HGNC=12767|UniProtKB=Q9BZ95 Q9BZ95 NSD3 PTHR22884:SF473 SET DOMAIN PROTEINS HISTONE-LYSINE N-METHYLTRANSFERASE NSD3 histone H3K36 methyltransferase activity#GO:0046975;protein methyltransferase activity#GO:0008276;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a protein#GO:0140096;protein-lysine N-methyltransferase activity#GO:0016279;histone methyltransferase activity#GO:0042054;N-methyltransferase activity#GO:0008170;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;lysine N-methyltransferase activity#GO:0016278;histone modifying activity#GO:0140993;histone H3 methyltransferase activity#GO:0140938 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 HUMAN|HGNC=6552|UniProtKB=O75610 O75610 LEFTY1 PTHR11848:SF257 TGF-BETA FAMILY LEFT-RIGHT DETERMINATION FACTOR 1 cytokine activity#GO:0005125;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772 anterior/posterior axis specification#GO:0009948;multicellular organism development#GO:0007275;anterior/posterior pattern specification#GO:0009952;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;cell surface receptor signaling pathway#GO:0007166;developmental process#GO:0032502;response to BMP#GO:0071772;cellular response to BMP stimulus#GO:0071773;regionalization#GO:0003002;multicellular organismal process#GO:0032501;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;cell communication#GO:0007154;cellular response to growth factor stimulus#GO:0071363;pattern specification process#GO:0007389;regulation of cellular process#GO:0050794;response to growth factor#GO:0070848;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;signaling#GO:0023052;response to endogenous stimulus#GO:0009719;BMP signaling pathway#GO:0030509;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 growth factor#PC00112 TGF-beta signaling pathway#P00052>TGFbeta#P01286 HUMAN|HGNC=24018|UniProtKB=Q9H568 Q9H568 ACTL8 PTHR11937:SF208 ACTIN ACTIN-LIKE PROTEIN 8 structural constituent of cytoskeleton#GO:0005200;structural molecule activity#GO:0005198 actin cytoskeleton#GO:0015629;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 actin and actin related protein#PC00039 Cadherin signaling pathway#P00012>F-actin#P00470;Cytoskeletal regulation by Rho GTPase#P00016>Actin#P00512;Nicotinic acetylcholine receptor signaling pathway#P00044>Actin#P01090;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>F-actin#P00858;Alzheimer disease-presenilin pathway#P00004>actin#P00114;Integrin signalling pathway#P00034>Actin#P00944;Huntington disease#P00029>Actin#P00807 HUMAN|Gene=YJ013_HUMAN|UniProtKB=Q6ZQT7 Q6ZQT7 PTHR37553:SF7 DUF4705 DOMAIN-CONTAINING PROTEIN DUF4705 DOMAIN-CONTAINING PROTEIN HUMAN|HGNC=24047|UniProtKB=Q8NHH9 Q8NHH9 ATL2 PTHR10751:SF42 GUANYLATE BINDING PROTEIN ATLASTIN-2 hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787 cellular component organization#GO:0016043;organelle organization#GO:0006996;endoplasmic reticulum organization#GO:0007029;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;endomembrane system organization#GO:0010256 heterotrimeric G-protein#PC00117;G-protein#PC00020 HUMAN|HGNC=21489|UniProtKB=Q9NTX5 Q9NTX5 ECHDC1 PTHR11941:SF27 ENOYL-COA HYDRATASE-RELATED ETHYLMALONYL-COA DECARBOXYLASE lyase activity#GO:0016829;carboxy-lyase activity#GO:0016831;catalytic activity#GO:0003824;carbon-carbon lyase activity#GO:0016830 lipid oxidation#GO:0034440;fatty acid catabolic process#GO:0009062;oxoacid metabolic process#GO:0043436;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;small molecule catabolic process#GO:0044282;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;lipid modification#GO:0030258;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;fatty acid oxidation#GO:0019395;lipid metabolic process#GO:0006629;fatty acid beta-oxidation#GO:0006635;monocarboxylic acid catabolic process#GO:0072329;lipid catabolic process#GO:0016042;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 lyase#PC00144;hydratase#PC00120;metabolite interconversion enzyme#PC00262 Succinate to proprionate conversion#P02777>Methylmalonyl-CoA decarboxylase#P03163 HUMAN|HGNC=18750|UniProtKB=Q8WYP3 Q8WYP3 RIN2 PTHR23101:SF51 RAB GDP/GTP EXCHANGE FACTOR RAS AND RAB INTERACTOR 2 guanyl-nucleotide exchange factor activity#GO:0005085;binding#GO:0005488;enzyme binding#GO:0019899;enzyme regulator activity#GO:0030234;small GTPase binding#GO:0031267;protein binding#GO:0005515;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function regulator activity#GO:0098772 intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;endocytic vesicle#GO:0030139;membrane-bounded organelle#GO:0043227;vesicle#GO:0031982;cytosol#GO:0005829;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 guanyl-nucleotide exchange factor#PC00113;protein-binding activity modulator#PC00095 HUMAN|HGNC=7972|UniProtKB=P49116 P49116 NR2C2 PTHR24083:SF48 NUCLEAR HORMONE RECEPTOR NUCLEAR RECEPTOR SUBFAMILY 2 GROUP C MEMBER 2 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;nuclear receptor activity#GO:0004879;cis-regulatory region sequence-specific DNA binding#GO:0000987;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulatory region nucleic acid binding#GO:0001067 cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of multicellular organismal development#GO:2000026;positive regulation of multicellular organismal process#GO:0051240;regulation of biological process#GO:0050789;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of macromolecule metabolic process#GO:0010604;regulation of multicellular organismal process#GO:0051239;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;regulation of developmental process#GO:0050793;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;developmental process#GO:0032502;positive regulation of developmental process#GO:0051094 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 C4 zinc finger nuclear receptor#PC00169;gene-specific transcriptional regulator#PC00264 CCKR signaling map#P06959>TAK1#P07170 HUMAN|HGNC=7835|UniProtKB=O95096 O95096 NKX2-2 PTHR24340:SF24 HOMEOBOX PROTEIN NKX HOMEOBOX PROTEIN NKX-2.2 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=6280|UniProtKB=O95279 O95279 KCNK5 PTHR11003:SF241 POTASSIUM CHANNEL, SUBFAMILY K POTASSIUM CHANNEL SUBFAMILY K MEMBER 5 transporter activity#GO:0005215;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261;outward rectifier potassium channel activity#GO:0015271;potassium channel activity#GO:0005267;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079 transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;transport#GO:0006810;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 ion channel#PC00133;transporter#PC00227 HUMAN|HGNC=17257|UniProtKB=O95238 O95238 SPDEF PTHR11849:SF182 ETS SAM POINTED DOMAIN-CONTAINING ETS TRANSCRIPTION FACTOR transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 developmental process#GO:0032502;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 winged helix/forkhead transcription factor#PC00246;DNA-binding transcription factor#PC00218 PDGF signaling pathway#P00047>Ets#P01167 HUMAN|HGNC=9052|UniProtKB=P00749 P00749 PLAU PTHR24264:SF38 TRYPSIN-RELATED UROKINASE-TYPE PLASMINOGEN ACTIVATOR serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;serine-type peptidase activity#GO:0008236 metabolic process#GO:0008152;negative regulation of response to wounding#GO:1903035;regulation of response to wounding#GO:1903034;cellular process#GO:0009987;fibrinolysis#GO:0042730;regulation of response to external stimulus#GO:0032101;protein maturation#GO:0051604;gene expression#GO:0010467;negative regulation of response to external stimulus#GO:0032102;regulation of multicellular organismal process#GO:0051239;proteolysis#GO:0006508;negative regulation of hemostasis#GO:1900047;negative regulation of coagulation#GO:0050819;regulation of biological quality#GO:0065008;negative regulation of biological process#GO:0048519;zymogen activation#GO:0031638;regulation of biological process#GO:0050789;regulation of blood coagulation#GO:0030193;regulation of body fluid levels#GO:0050878;regulation of wound healing#GO:0061041;negative regulation of blood coagulation#GO:0030195;regulation of response to stress#GO:0080134;regulation of response to stimulus#GO:0048583;macromolecule metabolic process#GO:0043170;plasminogen activation#GO:0031639;negative regulation of wound healing#GO:0061045;macromolecule biosynthetic process#GO:0009059;protein processing#GO:0016485;regulation of hemostasis#GO:1900046;regulation of coagulation#GO:0050818;regulation of cell adhesion#GO:0030155;negative regulation of response to stimulus#GO:0048585;biosynthetic process#GO:0009058;biological regulation#GO:0065007;protein metabolic process#GO:0019538;negative regulation of multicellular organismal process#GO:0051241;primary metabolic process#GO:0044238;regulation of cell adhesion mediated by integrin#GO:0033628;regulation of cellular process#GO:0050794 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease#PC00190;serine protease#PC00203 Plasminogen activating cascade#P00050>uPA#P01243;CCKR signaling map#P06959>uPA#P07039;CCKR signaling map#P06959>uPA#G06974;CCKR signaling map#P06959>uPA#G07267;Plasminogen activating cascade#P00050>pro-uPA#P01262;Blood coagulation#P00011>uPA#P00424;Blood coagulation#P00011>uPAR#P00433 HUMAN|HGNC=28379|UniProtKB=Q8TBF8 Q8TBF8 FAM81A PTHR22420:SF2 PROTEIN FAM81A PROTEIN FAM81A HUMAN|HGNC=12016|UniProtKB=P29144 P29144 TPP2 PTHR43806:SF14 PEPTIDASE S8 TRIPEPTIDYL-PEPTIDASE 2 serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 serine protease#PC00203 HUMAN|HGNC=29529|UniProtKB=Q9BZK7 Q9BZK7 TBL1XR1 PTHR22846:SF40 WD40 REPEAT PROTEIN F-BOX-LIKE_WD REPEAT-CONTAINING PROTEIN TBL1XR1 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;negative regulation of metabolic process#GO:0009892 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear protein-containing complex#GO:0140513;transcription regulator complex#GO:0005667;transcription repressor complex#GO:0017053;protein-containing complex#GO:0032991;membrane-enclosed lumen#GO:0031974;histone deacetylase complex#GO:0000118;nucleus#GO:0005634 Wnt signaling pathway#P00057>Ebi#P01453 HUMAN|HGNC=28696|UniProtKB=Q8N184 Q8N184 ZNF567 PTHR24404:SF98 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 567 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218 HUMAN|HGNC=10256|UniProtKB=Q01973 Q01973 ROR1 PTHR24416:SF134 TYROSINE-PROTEIN KINASE RECEPTOR INACTIVE TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR1 transferase activity#GO:0016740;kinase activity#GO:0016301;signaling receptor activity#GO:0038023;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888;protein binding#GO:0005515;Wnt-protein binding#GO:0017147;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein tyrosine kinase activity#GO:0004713;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;transmembrane receptor protein kinase activity#GO:0019199;transmembrane receptor protein tyrosine kinase activity#GO:0004714;molecular transducer activity#GO:0060089 positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of cell communication#GO:0010646;signaling#GO:0023052;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of signaling#GO:0023056;cell communication#GO:0007154;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;cellular process#GO:0009987;regulation of canonical NF-kappaB signal transduction#GO:0043122;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of cellular process#GO:0048522;positive regulation of canonical NF-kappaB signal transduction#GO:0043123;cell surface receptor signaling pathway#GO:0007166;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;cell projection#GO:0042995;membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005;signaling receptor complex#GO:0043235;axon#GO:0030424 transmembrane signal receptor#PC00197 HUMAN|HGNC=25094|UniProtKB=Q765P7 Q765P7 MTSS2 PTHR15708:SF8 ACTIN BUNDLING/MISSING IN METASTASIS-RELATED PROTEIN MTSS 2 protein binding#GO:0005515;lipid binding#GO:0008289;binding#GO:0005488;phospholipid binding#GO:0005543;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092 cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;membrane organization#GO:0061024;cellular component assembly#GO:0022607;cell projection organization#GO:0030030;cellular component organization or biogenesis#GO:0071840 intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;actin cytoskeleton#GO:0015629;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=16167|UniProtKB=Q5JPB2 Q5JPB2 ZNF831 PTHR47166:SF1 ZINC FINGER PROTEIN 831 ZINC FINGER PROTEIN 831 HUMAN|HGNC=3341|UniProtKB=Q04743 Q04743 EMX2 PTHR24339:SF25 HOMEOBOX PROTEIN EMX-RELATED HOMEOBOX PROTEIN EMX2 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987 regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;central nervous system development#GO:0007417;regulation of cellular process#GO:0050794;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;brain development#GO:0007420;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;nervous system development#GO:0007399;head development#GO:0060322;developmental process#GO:0032502;neuron differentiation#GO:0030182;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;animal organ development#GO:0048513;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 homeodomain transcription factor#PC00119 HUMAN|HGNC=23782|UniProtKB=Q9BY77 Q9BY77 POLDIP3 PTHR19965:SF96 RNA AND EXPORT FACTOR BINDING PROTEIN POLYMERASE DELTA-INTERACTING PROTEIN 3 RNA binding#GO:0003723;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488 nucleocytoplasmic transport#GO:0006913;nuclear export#GO:0051168;nuclear transport#GO:0051169;cellular localization#GO:0051641;mRNA export from nucleus#GO:0006406;nucleic acid transport#GO:0050657;localization#GO:0051179;mRNA transport#GO:0051028;establishment of RNA localization#GO:0051236;RNA transport#GO:0050658;RNA localization#GO:0006403;nucleobase-containing compound transport#GO:0015931;transport#GO:0006810;RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907;metabolic process#GO:0008152;establishment of localization#GO:0051234;poly(A)+ mRNA export from nucleus#GO:0016973;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;establishment of localization in cell#GO:0051649;nitrogen compound transport#GO:0071705;macromolecule localization#GO:0033036;biosynthetic process#GO:0009058;gene expression#GO:0010467 supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;nuclear body#GO:0016604;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membraneless organelle#GO:0043228;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear speck#GO:0016607;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031 HUMAN|HGNC=14522|UniProtKB=Q9UGB7 Q9UGB7 MIOX PTHR12588:SF0 MYOINOSITOL OXYGENASE INOSITOL OXYGENASE monooxygenase activity#GO:0004497;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 cellular process#GO:0009987;alcohol metabolic process#GO:0006066;metabolic process#GO:0008152;small molecule catabolic process#GO:0044282;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056 oxygenase#PC00177 HUMAN|HGNC=25805|UniProtKB=Q9H8S5 Q9H8S5 CCNP PTHR10177:SF257 CYCLINS CYCLIN-P cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538;cyclin-dependent protein kinase regulator activity#GO:0019914;protein kinase regulator activity#GO:0019887;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;enzyme regulator activity#GO:0030234 cell cycle phase transition#GO:0044770;mitotic cell cycle#GO:0000278;cell cycle#GO:0007049;cellular process#GO:0009987;cell cycle process#GO:0022402;cell cycle G1/S phase transition#GO:0044843;mitotic cell cycle process#GO:1903047;G1/S transition of mitotic cell cycle#GO:0000082;mitotic cell cycle phase transition#GO:0044772 nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;protein kinase complex#GO:1902911;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227 kinase activator#PC00138 HUMAN|HGNC=6769|UniProtKB=P84022 P84022 SMAD3 PTHR13703:SF53 SMAD SMAD FAMILY MEMBER 3 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;protein binding#GO:0005515;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677 cellular response to growth factor stimulus#GO:0071363;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;activin receptor signaling pathway#GO:0032924;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;cellular response to endogenous stimulus#GO:0071495;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;response to endogenous stimulus#GO:0009719;cellular response to BMP stimulus#GO:0071773;cell surface receptor signaling pathway#GO:0007166;positive regulation of transcription by RNA polymerase II#GO:0045944;intracellular signaling cassette#GO:0141124;positive regulation of macromolecule metabolic process#GO:0010604;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;transforming growth factor beta receptor signaling pathway#GO:0007179;intracellular signal transduction#GO:0035556;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;cell communication#GO:0007154;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;response to transforming growth factor beta#GO:0071559;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;response to growth factor#GO:0070848;regulation of cellular process#GO:0050794;cellular response to transforming growth factor beta stimulus#GO:0071560;BMP signaling pathway#GO:0030509;cellular response to stimulus#GO:0051716;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;response to BMP#GO:0071772;developmental process#GO:0032502;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 Gonadotropin-releasing hormone receptor pathway#P06664>SMAD2-4#P06819;TGF-beta signaling pathway#P00052>RSmads#P01292 HUMAN|HGNC=26433|UniProtKB=Q96NC0 Q96NC0 ZMAT2 PTHR45986:SF1 ZINC FINGER MATRIN-TYPE PROTEIN 2 ZINC FINGER MATRIN-TYPE PROTEIN 2 mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377 intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;U4/U6 x U5 tri-snRNP complex#GO:0046540;nucleus#GO:0005634;small nuclear ribonucleoprotein complex#GO:0030532;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Sm-like protein family complex#GO:0120114;spliceosomal snRNP complex#GO:0097525;nuclear protein-containing complex#GO:0140513;spliceosomal tri-snRNP complex#GO:0097526;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904 RNA processing factor#PC00147 HUMAN|HGNC=1550|UniProtKB=P35520 P35520 CBS PTHR10314:SF194 CYSTATHIONINE BETA-SYNTHASE CYSTATHIONINE BETA-SYNTHASE catalytic activity#GO:0003824;hydro-lyase activity#GO:0016836;lyase activity#GO:0016829;carbon-oxygen lyase activity#GO:0016835 proteinogenic amino acid biosynthetic process#GO:0170038;small molecule biosynthetic process#GO:0044283;amino acid biosynthetic process#GO:0008652;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;amino acid metabolic process#GO:0006520;biosynthetic process#GO:0009058;proteinogenic amino acid metabolic process#GO:0170039;small molecule metabolic process#GO:0044281;carboxylic acid biosynthetic process#GO:0046394;cellular process#GO:0009987;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;sulfur compound metabolic process#GO:0006790 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;lyase#PC00144 Cysteine biosynthesis#P02737>O-Acetylserine-lyase#P02887 HUMAN|HGNC=25826|UniProtKB=Q9H0V1 Q9H0V1 TMEM168 PTHR14437:SF2 TRANSMEMBRANE PROTEIN 168 TRANSMEMBRANE PROTEIN 168 HUMAN|HGNC=28529|UniProtKB=Q6ZMJ4 Q6ZMJ4 IL34 PTHR28606:SF1 INTERLEUKIN-34 INTERLEUKIN-34 protein binding#GO:0005515;cytokine receptor binding#GO:0005126;signaling receptor binding#GO:0005102;binding#GO:0005488 regulation of myeloid cell differentiation#GO:0045637;regulation of hemopoiesis#GO:1903706;regulation of cell population proliferation#GO:0042127;regulation of biological process#GO:0050789;positive regulation of multicellular organismal process#GO:0051240;regulation of multicellular organismal development#GO:2000026;positive regulation of cell population proliferation#GO:0008284;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;positive regulation of developmental process#GO:0051094;positive regulation of cell differentiation#GO:0045597;regulation of cell differentiation#GO:0045595;positive regulation of myeloid cell differentiation#GO:0045639;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of cell development#GO:0060284;positive regulation of immune system process#GO:0002684;biological regulation#GO:0065007;positive regulation of cell development#GO:0010720;regulation of multicellular organismal process#GO:0051239 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 interleukin superfamily#PC00128 HUMAN|HGNC=11072|UniProtKB=Q9UBY0 Q9UBY0 SLC9A2 PTHR10110:SF89 SODIUM/HYDROGEN EXCHANGER SODIUM_HYDROGEN EXCHANGER 2 sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;monoatomic ion transmembrane transporter activity#GO:0015075;metal cation:proton antiporter activity#GO:0051139;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;antiporter activity#GO:0015297;proton transmembrane transporter activity#GO:0015078;monoatomic cation transmembrane transporter activity#GO:0008324;potassium ion transmembrane transporter activity#GO:0015079 regulation of intracellular pH#GO:0051453;regulation of pH#GO:0006885;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;sodium ion transport#GO:0006814;intracellular monoatomic ion homeostasis#GO:0006873;homeostatic process#GO:0042592;metal ion transport#GO:0030001;inorganic ion import across plasma membrane#GO:0099587;import across plasma membrane#GO:0098739;monoatomic cation homeostasis#GO:0055080;transport#GO:0006810;intracellular monoatomic cation homeostasis#GO:0030003;chemical homeostasis#GO:0048878;intracellular chemical homeostasis#GO:0055082;inorganic cation import across plasma membrane#GO:0098659;cellular homeostasis#GO:0019725;establishment of localization#GO:0051234;import into cell#GO:0098657;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801;potassium ion transmembrane transport#GO:0071805;biological regulation#GO:0065007;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 secondary carrier transporter#PC00258 HUMAN|HGNC=12133|UniProtKB=A0A0B4J273 A0A0B4J273 TRAV34 PTHR19433:SF84 T-CELL RECEPTOR ALPHA CHAIN V REGION-RELATED T CELL RECEPTOR ALPHA VARIABLE 34 response to biotic stimulus#GO:0009607;response to bacterium#GO:0009617;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to external stimulus#GO:0009605;response to other organism#GO:0051707;response to stimulus#GO:0050896 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=686|UniProtKB=Q15669 Q15669 RHOH PTHR24072:SF306 RHO FAMILY GTPASE RHO-RELATED GTP-BINDING PROTEIN RHOH hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;kinase binding#GO:0019900;binding#GO:0005488;nucleoside phosphate binding#GO:1901265;enzyme binding#GO:0019899;guanyl nucleotide binding#GO:0019001;protein kinase binding#GO:0019901;protein binding#GO:0005515;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;hydrolase activity, acting on acid anhydrides#GO:0016817;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;small molecule binding#GO:0036094;anion binding#GO:0043168;GTPase activity#GO:0003924;ion binding#GO:0043167;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleotide binding#GO:0000166 regulation of developmental process#GO:0050793;signaling#GO:0023052;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;regulation of cytoskeleton organization#GO:0051493;regulation of cell shape#GO:0008360;regulation of organelle organization#GO:0033043;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;regulation of biological quality#GO:0065008;supramolecular fiber organization#GO:0097435;cell communication#GO:0007154;actin filament-based process#GO:0030029;cortical cytoskeleton organization#GO:0030865;establishment or maintenance of cell polarity#GO:0007163;regulation of actin cytoskeleton organization#GO:0032956;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;cellular process#GO:0009987;signal transduction#GO:0007165;organelle organization#GO:0006996;actin filament organization#GO:0007015;regulation of anatomical structure morphogenesis#GO:0022603;cellular component organization or biogenesis#GO:0071840;regulation of actin filament-based process#GO:0032970 intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cell projection#GO:0042995;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;cell periphery#GO:0071944;cytoplasm#GO:0005737;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228 G-protein#PC00020;small GTPase#PC00208 HUMAN|HGNC=9786|UniProtKB=P20340 P20340 RAB6A PTHR24073:SF1089 DRAB5-RELATED RAS-RELATED PROTEIN RAB-6A-RELATED hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817 vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;establishment of protein localization#GO:0045184;macromolecule localization#GO:0033036;retrograde transport, endosome to Golgi#GO:0042147;intracellular protein localization#GO:0008104;endosomal transport#GO:0016197;establishment of localization#GO:0051234;Golgi vesicle transport#GO:0048193;intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907;protein localization to Golgi apparatus#GO:0034067;cytosolic transport#GO:0016482;protein localization to organelle#GO:0033365;intra-Golgi vesicle-mediated transport#GO:0006891;protein localization to membrane#GO:0072657;protein transport#GO:0015031;cellular localization#GO:0051641;localization#GO:0051179;localization within membrane#GO:0051668 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 G-protein#PC00020;small GTPase#PC00208 HUMAN|HGNC=20352|UniProtKB=Q9H867 Q9H867 VCPKMT PTHR14614:SF158 HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN PROTEIN N-LYSINE METHYLTRANSFERASE METTL21D methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;protein-lysine N-methyltransferase activity#GO:0016279;N-methyltransferase activity#GO:0008170;lysine N-methyltransferase activity#GO:0016278;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741;protein methyltransferase activity#GO:0008276;catalytic activity, acting on a protein#GO:0140096 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 protein modifying enzyme#PC00260 HUMAN|HGNC=8998|UniProtKB=P78356 P78356 PIP4K2B PTHR23086:SF22 PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE TYPE-2 BETA lipid kinase activity#GO:0001727;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphatidylinositol kinase activity#GO:0052742;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824 organophosphate biosynthetic process#GO:0090407;phosphatidylinositol phosphate biosynthetic process#GO:0046854;phospholipid metabolic process#GO:0006644;glycerolipid metabolic process#GO:0046486;phospholipid biosynthetic process#GO:0008654;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;glycerophospholipid biosynthetic process#GO:0046474;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;biosynthetic process#GO:0009058;glycerophospholipid metabolic process#GO:0006650;lipid biosynthetic process#GO:0008610;glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transferase#PC00220;kinase#PC00137 HUMAN|HGNC=14301|UniProtKB=Q702N8 Q702N8 XIRP1 PTHR22591:SF2 XIN XIN ACTIN-BINDING REPEAT-CONTAINING PROTEIN 1 protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;actin filament binding#GO:0051015 cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;actin cytoskeleton organization#GO:0030036;cytoskeleton organization#GO:0007010;actin filament-based process#GO:0030029;cellular component organization or biogenesis#GO:0071840;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015 intracellular membraneless organelle#GO:0043232;cell-substrate junction#GO:0030055;focal adhesion#GO:0005925;organelle#GO:0043226;cellular anatomical structure#GO:0110165;actomyosin#GO:0042641;actin cytoskeleton#GO:0015629;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;cell junction#GO:0030054;actin filament bundle#GO:0032432;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;stress fiber#GO:0001725 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=25395|UniProtKB=Q6ZN66 Q6ZN66 GBP6 PTHR10751:SF117 GUANYLATE BINDING PROTEIN GUANYLATE-BINDING PROTEIN 6 ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982 heterotrimeric G-protein#PC00117;G-protein#PC00020 HUMAN|HGNC=34244|UniProtKB=Q5T4T1 Q5T4T1 TMEM170B PTHR22779:SF4 SD17342P TRANSMEMBRANE PROTEIN 170B negative regulation of cell communication#GO:0010648;negative regulation of canonical Wnt signaling pathway#GO:0090090;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;negative regulation of Wnt signaling pathway#GO:0030178;negative regulation of response to stimulus#GO:0048585;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of signal transduction#GO:0009968;regulation of canonical Wnt signaling pathway#GO:0060828 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=29401|UniProtKB=Q5VVJ2 Q5VVJ2 MYSM1 PTHR12802:SF189 SWI/SNF COMPLEX-RELATED DEUBIQUITINASE MYSM1 transcription coactivator activity#GO:0003713;protein binding#GO:0005515;transcription regulator activity#GO:0140110;histone binding#GO:0042393;binding#GO:0005488;transcription coregulator activity#GO:0003712 regulation of biological process#GO:0050789;cellular component organization#GO:0016043;positive regulation of RNA metabolic process#GO:0051254;chromatin remodeling#GO:0006338;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of DNA-templated transcription#GO:0006355;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of RNA biosynthetic process#GO:2001141;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of gene expression#GO:0010468;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=11117|UniProtKB=Q16637 Q16637 SMN1 PTHR13681:SF34 SURVIVAL OF MOTOR NEURON-RELATED-SPLICING FACTOR 30-RELATED SURVIVAL MOTOR NEURON PROTEIN RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell development#GO:0048468;ribonucleoprotein complex biogenesis#GO:0022613;mRNA metabolic process#GO:0016071;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;protein-containing complex assembly#GO:0065003;mRNA splicing, via spliceosome#GO:0000398;RNA metabolic process#GO:0016070;neuron development#GO:0048666;axonogenesis#GO:0007409;animal gross anatomical part developmental process#GO:0160108;nucleic acid biosynthetic process#GO:0141187;generation of neurons#GO:0048699;gene expression#GO:0010467;cellular component assembly#GO:0022607;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;RNA processing#GO:0006396;mRNA processing#GO:0006397;neuron projection development#GO:0031175;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;protein-RNA complex organization#GO:0071826;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;protein-containing complex organization#GO:0043933;cell projection morphogenesis#GO:0048858;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;plasma membrane bounded cell projection morphogenesis#GO:0120039;RNA splicing#GO:0008380;neuron differentiation#GO:0030182;spliceosomal snRNP assembly#GO:0000387;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;protein-RNA complex assembly#GO:0022618;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;anatomical structure development#GO:0048856;system development#GO:0048731;RNA splicing, via transesterification reactions#GO:0000375;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;axon development#GO:0061564;macromolecule biosynthetic process#GO:0009059;cellular developmental process#GO:0048869;macromolecule metabolic process#GO:0043170;neurogenesis#GO:0022008;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;SMN complex#GO:0032797;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;SMN-Sm protein complex#GO:0034719;organelle lumen#GO:0043233;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;Sm-like protein family complex#GO:0120114;membraneless organelle#GO:0043228;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;nuclear body#GO:0016604 RNA splicing factor#PC00148 HUMAN|HGNC=77|UniProtKB=P42684 P42684 ABL2 PTHR24418:SF87 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE ABL2 phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein tyrosine kinase activity#GO:0004713;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096 regulation of cellular process#GO:0050794;epidermal growth factor receptor signaling pathway#GO:0007173;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular process#GO:0009987;ERBB signaling pathway#GO:0038127;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 non-receptor tyrosine protein kinase#PC00168 HUMAN|HGNC=4749|UniProtKB=Q99877 Q99877 H2BC15 PTHR23428:SF339 HISTONE H2B HISTONE H2B TYPE 1-N biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to stimulus#GO:0050896;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;defense response to bacterium#GO:0042742;immune system process#GO:0002376;response to bacterium#GO:0009617;response to other organism#GO:0051707;defense response to other organism#GO:0098542;defense response to symbiont#GO:0140546;immune response#GO:0006955;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;defense response#GO:0006952;response to external stimulus#GO:0009605;innate immune response#GO:0045087;antibacterial humoral response#GO:0019731;antimicrobial humoral response#GO:0019730;humoral immune response#GO:0006959 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=14399|UniProtKB=Q9H3G5 Q9H3G5 CPVL PTHR11802:SF472 SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE SERINE CARBOXYPEPTIDASE CPVL-RELATED serine-type peptidase activity#GO:0008236;carboxypeptidase activity#GO:0004180;serine hydrolase activity#GO:0017171;exopeptidase activity#GO:0008238;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096 serine protease#PC00203 HUMAN|Ensembl=ENSG00000269825.5|UniProtKB=A0A7P0TAN4 A0A7P0TAN4 LOC122539214 PTHR24393:SF88 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 808 sequence-specific double-stranded DNA binding#GO:1990837;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription cis-regulatory region binding#GO:0000976;sequence-specific DNA binding#GO:0043565;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;transcription regulatory region nucleic acid binding#GO:0001067;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;DNA-binding transcription activator activity#GO:0001216 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=28728|UniProtKB=Q86UD3 Q86UD3 MARCHF3 PTHR46065:SF2 E3 UBIQUITIN-PROTEIN LIGASE MARCH 2/3 FAMILY MEMBER E3 UBIQUITIN-PROTEIN LIGASE MARCHF3 catalytic activity, acting on a protein#GO:0140096;ubiquitin-protein transferase activity#GO:0004842;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787 macromolecule metabolic process#GO:0043170;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;protein modification by small protein conjugation#GO:0032446;cellular process#GO:0009987;protein modification process#GO:0036211;primary metabolic process#GO:0044238 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=6142|UniProtKB=P23229 P23229 ITGA6 PTHR23220:SF9 INTEGRIN ALPHA INTEGRIN ALPHA-6 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cell communication#GO:0007154;cell-substrate adhesion#GO:0031589;cell adhesion#GO:0007155;cell-matrix adhesion#GO:0007160;immune system process#GO:0002376;signaling#GO:0023052;cell motility#GO:0048870;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;integrin-mediated signaling pathway#GO:0007229;cell surface receptor signaling pathway#GO:0007166;leukocyte migration#GO:0050900;biological regulation#GO:0065007;cell migration#GO:0016477;cellular process#GO:0009987;signal transduction#GO:0007165;cell-cell adhesion#GO:0098609 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;plasma membrane#GO:0005886;membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;protein complex involved in cell adhesion#GO:0098636;integrin complex#GO:0008305;signaling receptor complex#GO:0043235 integrin#PC00126;cell adhesion molecule#PC00069 Integrin signalling pathway#P00034>Integrin alpha#P00941 HUMAN|HGNC=190|UniProtKB=O43184 O43184 ADAM12 PTHR11905:SF112 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 12 catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222 cellular process#GO:0009987;metabolic process#GO:0008152;proteolysis#GO:0006508;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 metalloprotease#PC00153;protease#PC00190 HUMAN|HGNC=4206|UniProtKB=P04001 P04001 OPN1MW PTHR24240:SF17 OPSIN MEDIUM-WAVE-SENSITIVE OPSIN 1-RELATED transmembrane signaling receptor activity#GO:0004888;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 response to abiotic stimulus#GO:0009628;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to light stimulus#GO:0009416;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cellular response to environmental stimulus#GO:0104004;cellular response to radiation#GO:0071478;signaling#GO:0023052;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;detection of stimulus#GO:0051606;signal transduction#GO:0007165;cellular response to light stimulus#GO:0071482;response to radiation#GO:0009314;cellular process#GO:0009987;biological regulation#GO:0065007;cellular response to abiotic stimulus#GO:0071214;response to external stimulus#GO:0009605 membrane-bounded organelle#GO:0043227;non-motile cilium#GO:0097730;cilium#GO:0005929;organelle#GO:0043226;photoreceptor outer segment#GO:0001750;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane#GO:0005886;plasma membrane bounded cell projection#GO:0120025;9+0 non-motile cilium#GO:0097731;membrane#GO:0016020;neuron projection#GO:0043005;photoreceptor cell cilium#GO:0097733;cell periphery#GO:0071944 G-protein coupled receptor#PC00021 HUMAN|HGNC=29971|UniProtKB=Q8WVF1 Q8WVF1 OSCP1 PTHR21439:SF0 OXIDORED-NITRO DOMAIN-CONTAINING PROTEIN PROTEIN OSCP1 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=17884|UniProtKB=Q8NHX4 Q8NHX4 SPATA3 PTHR22234:SF0 TESTIS SPERMATOCYTE APOPTOSIS-RELATED GENE 1 PROTEIN SPERMATOGENESIS-ASSOCIATED PROTEIN 3 cilium#GO:0005929;9+2 motile cilium#GO:0097729;membrane-bounded organelle#GO:0043227;motile cilium#GO:0031514;organelle#GO:0043226;sperm flagellum#GO:0036126;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025 HUMAN|HGNC=9153|UniProtKB=Q8N490 Q8N490 PNKD PTHR11935:SF116 BETA LACTAMASE DOMAIN THIOESTERASE PNKD-RELATED hydrolase activity, acting on ester bonds#GO:0016788;thiolester hydrolase activity#GO:0016790;catalytic activity#GO:0003824;hydrolase activity#GO:0016787 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739 HUMAN|HGNC=20243|UniProtKB=Q8TAV3 Q8TAV3 CYP2W1 PTHR24300:SF291 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 2W1 tetrapyrrole binding#GO:0046906;binding#GO:0005488;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen#GO:0016712;heme binding#GO:0020037;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824;monooxygenase activity#GO:0004497 response to stimulus#GO:0050896;response to chemical#GO:0042221;xenobiotic metabolic process#GO:0006805;cellular response to xenobiotic stimulus#GO:0071466;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;metabolic process#GO:0008152;cellular response to chemical stimulus#GO:0070887;response to xenobiotic stimulus#GO:0009410 intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 oxygenase#PC00177;oxidoreductase#PC00176 HUMAN|HGNC=19651|UniProtKB=Q8IYB5 Q8IYB5 SMAP1 PTHR45705:SF8 FI20236P1 STROMAL MEMBRANE-ASSOCIATED PROTEIN 1 molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;enzyme activator activity#GO:0008047 regulation of transport#GO:0051049;regulation of localization#GO:0032879;regulation of endocytosis#GO:0030100;biological regulation#GO:0065007;regulation of receptor-mediated endocytosis#GO:0048259;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=25986|UniProtKB=Q6P3X3 Q6P3X3 TTC27 PTHR16193:SF0 TETRATRICOPEPTIDE REPEAT PROTEIN 27 TETRATRICOPEPTIDE REPEAT PROTEIN 27 HUMAN|HGNC=29650|UniProtKB=Q99640 Q99640 PKMYT1 PTHR11042:SF183 EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824 reproductive process#GO:0022414;cell cycle#GO:0007049;meiotic cell cycle#GO:0051321;cellular process#GO:0009987;sexual reproduction#GO:0019953 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=31795|UniProtKB=A6PVI3 A6PVI3 NCBP2L PTHR18847:SF5 20 KD NUCLEAR CAP BINDING PROTEIN NUCLEAR CAP-BINDING PROTEIN SUBUNIT 2-LIKE nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;mRNA splicing, via spliceosome#GO:0000398;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;RNA catabolic process#GO:0006401;nucleic acid biosynthetic process#GO:0141187;cellular localization#GO:0051641;RNA metabolic process#GO:0016070;mRNA export from nucleus#GO:0006406;mRNA processing#GO:0006397;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;gene expression#GO:0010467;RNA processing#GO:0006396;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule catabolic process#GO:0009057;RNA splicing#GO:0008380;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of macromolecule metabolic process#GO:0060255;nucleobase-containing compound transport#GO:0015931;catabolic process#GO:0009056;RNA localization#GO:0006403;regulation of cellular process#GO:0050794;RNA transport#GO:0050658;RNA biosynthetic process#GO:0032774;establishment of RNA localization#GO:0051236;mRNA transport#GO:0051028;RNA splicing, via transesterification reactions#GO:0000375;nucleocytoplasmic transport#GO:0006913;localization#GO:0051179;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;nucleic acid transport#GO:0050657;nuclear transport#GO:0051169;nuclear export#GO:0051168;nucleobase-containing compound catabolic process#GO:0034655;macromolecule localization#GO:0033036;regulation of metabolic process#GO:0019222;nitrogen compound transport#GO:0071705;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;macromolecule biosynthetic process#GO:0009059;nucleic acid catabolic process#GO:0141188;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;negative regulation of cellular process#GO:0048523;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;transport#GO:0006810;macromolecule metabolic process#GO:0043170;establishment of localization#GO:0051234;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031 HUMAN|HGNC=16909|UniProtKB=O14777 O14777 NDC80 PTHR10643:SF2 KINETOCHORE PROTEIN NDC80 KINETOCHORE PROTEIN NDC80 HOMOLOG chromosome localization#GO:0050000;cellular process#GO:0009987;attachment of spindle microtubules to kinetochore#GO:0008608;organelle organization#GO:0006996;mitotic sister chromatid segregation#GO:0000070;chromosome organization#GO:0051276;mitotic cell cycle process#GO:1903047;cellular component organization or biogenesis#GO:0071840;chromosome segregation#GO:0007059;metaphase chromosome alignment#GO:0051310;mitotic cell cycle#GO:0000278;mitotic nuclear division#GO:0140014;cell cycle process#GO:0022402;mitotic metaphase chromosome alignment#GO:0007080;nuclear chromosome segregation#GO:0098813;sister chromatid segregation#GO:0000819;cellular component organization#GO:0016043;cell cycle#GO:0007049;organelle fission#GO:0048285;localization#GO:0051179;attachment of mitotic spindle microtubules to kinetochore#GO:0051315;organelle localization#GO:0051640;nuclear division#GO:0000280 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;supramolecular complex#GO:0099080;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;condensed chromosome, centromeric region#GO:0000779;chromosome#GO:0005694;kinetochore#GO:0000776;membraneless organelle#GO:0043228;outer kinetochore#GO:0000940;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;condensed chromosome#GO:0000793;chromosome, centromeric region#GO:0000775;intracellular organelle#GO:0043229 transcription cofactor#PC00217 HUMAN|HGNC=11370|UniProtKB=O95793 O95793 STAU1 PTHR46054:SF2 MATERNAL EFFECT PROTEIN STAUFEN DOUBLE-STRANDED RNA-BINDING PROTEIN STAUFEN HOMOLOG 1 RNA binding#GO:0003723;double-stranded RNA binding#GO:0003725;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729 protein localization to synapse#GO:0035418;establishment of localization#GO:0051234;cellular developmental process#GO:0048869;transport along microtubule#GO:0010970;intracellular protein localization#GO:0008104;microtubule-based process#GO:0007017;intracellular transport#GO:0046907;developmental process#GO:0032502;transport#GO:0006810;cytoskeleton-dependent intracellular transport#GO:0030705;macromolecule localization#GO:0033036;axo-dendritic transport#GO:0008088;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;localization#GO:0051179;anatomical structure development#GO:0048856;cellular localization#GO:0051641;multicellular organismal reproductive process#GO:0048609;protein localization to cell junction#GO:1902414;sexual reproduction#GO:0019953;microtubule-based transport#GO:0099111;cell differentiation#GO:0030154;microtubule-based movement#GO:0007018;RNA localization#GO:0006403;gamete generation#GO:0007276;cellular process involved in reproduction in multicellular organism#GO:0022412;cell development#GO:0048468;reproductive process#GO:0022414;developmental process involved in reproduction#GO:0003006;germ cell development#GO:0007281 cell projection#GO:0042995;neuronal cell body#GO:0043025;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;cell body#GO:0044297;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;somatodendritic compartment#GO:0036477;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020;cytoplasmic stress granule#GO:0010494;membraneless organelle#GO:0043228 HUMAN|HGNC=439|UniProtKB=P05187 P05187 ALPP PTHR11596:SF69 ALKALINE PHOSPHATASE ALKALINE PHOSPHATASE, PLACENTAL TYPE hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 hydrolase#PC00121;phosphatase#PC00181 HUMAN|HGNC=26600|UniProtKB=Q562E7 Q562E7 WDR81 PTHR44662:SF1 WD REPEAT-CONTAINING PROTEIN 81 WD REPEAT-CONTAINING PROTEIN 81 enzyme regulator activity#GO:0030234;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772 macroautophagy#GO:0016236;process utilizing autophagic mechanism#GO:0061919;catabolic process#GO:0009056;cellular process#GO:0009987;autophagy#GO:0006914;metabolic process#GO:0008152 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=29308|UniProtKB=Q9HCM7 Q9HCM7 FBRSL1 PTHR14429:SF20 FIBROSIN FAMILY MEMBER FIBROSIN-1-LIKE PROTEIN HUMAN|HGNC=12336|UniProtKB=Q9UBN4 Q9UBN4 TRPC4 PTHR10117:SF25 TRANSIENT RECEPTOR POTENTIAL CHANNEL SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 4 monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;alcohol binding#GO:0043178;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;binding#GO:0005488;monoatomic cation channel activity#GO:0005261;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;channel activity#GO:0015267;anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167 transport#GO:0006810;intracellular monoatomic cation homeostasis#GO:0030003;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;establishment of localization#GO:0051234;calcium ion transport#GO:0006816;cellular homeostasis#GO:0019725;intracellular calcium ion homeostasis#GO:0006874;intracellular chemical homeostasis#GO:0055082;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;calcium ion homeostasis#GO:0055074;inorganic ion homeostasis#GO:0098771;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;intracellular monoatomic ion homeostasis#GO:0006873;calcium ion transmembrane transport#GO:0070588;regulation of cytosolic calcium ion concentration#GO:0051480;homeostatic process#GO:0042592;metal ion transport#GO:0030001 transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;cation channel complex#GO:0034703;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane protein complex#GO:0098796;membrane#GO:0016020;cell periphery#GO:0071944 ion channel#PC00133 Alzheimer disease-presenilin pathway#P00004>Capacitative calcium channels#P00124 HUMAN|HGNC=24238|UniProtKB=Q5VT06 Q5VT06 CEP350 PTHR13958:SF4 CENTROSOME-ASSOCIATED PROTEIN 350 CENTROSOME-ASSOCIATED PROTEIN 350 non-motor microtubule binding protein#PC00166;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=5735|UniProtKB=A0A075B6S5 A0A075B6S5 IGKV1-27 PTHR23267:SF531 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN KAPPA VARIABLE 1-27 immune response#GO:0006955;immune system process#GO:0002376;response to stimulus#GO:0050896 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=11305|UniProtKB=Q96SB4 Q96SB4 SRPK1 PTHR47634:SF4 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED SRSF PROTEIN KINASE 1 protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096 macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;regulation of mRNA processing#GO:0050684;regulation of nucleobase-containing compound metabolic process#GO:0019219;RNA splicing, via transesterification reactions#GO:0000375;regulation of RNA metabolic process#GO:0051252;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;protein-RNA complex assembly#GO:0022618;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;cellular response to stimulus#GO:0051716;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;regulation of mRNA metabolic process#GO:1903311;protein-RNA complex organization#GO:0071826;signal transduction#GO:0007165;cellular process#GO:0009987;mRNA processing#GO:0006397;cellular component biogenesis#GO:0044085;RNA processing#GO:0006396;cellular component assembly#GO:0022607;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;spliceosomal complex assembly#GO:0000245;RNA metabolic process#GO:0016070;protein-containing complex assembly#GO:0065003;mRNA splicing, via spliceosome#GO:0000398;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;signaling#GO:0023052;mRNA metabolic process#GO:0016071;ribonucleoprotein complex biogenesis#GO:0022613;response to stimulus#GO:0050896 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 HUMAN|HGNC=27421|UniProtKB=Q8N6V4 Q8N6V4 C10orf53 PTHR28448:SF1 UPF0728 PROTEIN C10ORF53 UPF0728 PROTEIN C10ORF53 HUMAN|HGNC=26244|UniProtKB=Q8IW35 Q8IW35 CEP97 PTHR45973:SF2 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED CENTROSOMAL PROTEIN OF 97 KDA regulation of cell projection assembly#GO:0060491;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;negative regulation of cellular component organization#GO:0051129;negative regulation of organelle organization#GO:0010639;negative regulation of biological process#GO:0048519;regulation of cellular component biogenesis#GO:0044087;regulation of cellular process#GO:0050794;regulation of plasma membrane bounded cell projection assembly#GO:0120032;regulation of cellular component organization#GO:0051128;regulation of cilium assembly#GO:1902017;negative regulation of cellular process#GO:0048523;regulation of cell projection organization#GO:0031344;regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of organelle assembly#GO:1902115;biological regulation#GO:0065007 centriole#GO:0005814;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;microtubule cytoskeleton#GO:0015630;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;centrosome#GO:0005813;microtubule organizing center#GO:0005815 phosphatase modulator#PC00184;protein-binding activity modulator#PC00095 HUMAN|HGNC=12980|UniProtKB=O75820 O75820 ZNF189 PTHR24377:SF316 IP01015P-RELATED ZINC FINGER PROTEIN 189 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=24307|UniProtKB=A4FU01 A4FU01 MTMR11 PTHR10807:SF51 MYOTUBULARIN-RELATED MYOTUBULARIN-RELATED PROTEIN 11 phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791 phosphatidylinositol metabolic process#GO:0046488;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;phosphatidylinositol dephosphorylation#GO:0046856;dephosphorylation#GO:0016311;lipid modification#GO:0030258;phospholipid dephosphorylation#GO:0046839;phosphate-containing compound metabolic process#GO:0006796;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phospholipid metabolic process#GO:0006644;glycerophospholipid metabolic process#GO:0006650;glycerolipid metabolic process#GO:0046486 membrane#GO:0016020;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 phosphatase#PC00181 HUMAN|HGNC=23112|UniProtKB=Q8TDW7 Q8TDW7 FAT3 PTHR24026:SF49 FAT ATYPICAL CADHERIN-RELATED PROTOCADHERIN FAT 3 cellular process#GO:0009987;cell adhesion#GO:0007155;cell-cell adhesion#GO:0098609 cell-cell junction#GO:0005911;cellular anatomical structure#GO:0110165;cell junction#GO:0030054;anchoring junction#GO:0070161;adherens junction#GO:0005912 cadherin#PC00057 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HUMAN|HGNC=13744|UniProtKB=Q15011 Q15011 HERPUD1 PTHR12943:SF7 HOMOCYSTEINE-RESPONSIVE ENDOPLASMIC RETICULUM-RESIDENT UNIQUITIN-LIKE DOMAIN HERPUD PROTEIN FAMILY MEMBER HOMOCYSTEINE-RESPONSIVE ENDOPLASMIC RETICULUM-RESIDENT UBIQUITIN-LIKE DOMAIN MEMBER 1 PROTEIN binding#GO:0005488;transmembrane transporter binding#GO:0044325;protein binding#GO:0005515 endoplasmic reticulum unfolded protein response#GO:0030968;negative regulation of apoptotic process#GO:0043066;regulation of signal transduction#GO:0009966;regulation of response to stress#GO:0080134;intracellular monoatomic cation homeostasis#GO:0030003;ubiquitin-dependent protein catabolic process#GO:0006511;intracellular chemical homeostasis#GO:0055082;regulation of intrinsic apoptotic signaling pathway#GO:2001242;regulation of response to endoplasmic reticulum stress#GO:1905897;catabolic process#GO:0009056;homeostatic process#GO:0042592;cellular response to unfolded protein#GO:0034620;response to endoplasmic reticulum stress#GO:0034976;protein metabolic process#GO:0019538;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of protein catabolic process#GO:0042176;regulation of protein metabolic process#GO:0051246;monoatomic ion homeostasis#GO:0050801;response to stress#GO:0006950;metabolic process#GO:0008152;chemical homeostasis#GO:0048878;negative regulation of intrinsic apoptotic signaling pathway#GO:2001243;regulation of apoptotic process#GO:0042981;intracellular calcium ion homeostasis#GO:0006874;regulation of programmed cell death#GO:0043067;signaling#GO:0023052;regulation of intracellular signal transduction#GO:1902531;modification-dependent macromolecule catabolic process#GO:0043632;inorganic ion homeostasis#GO:0098771;cellular response to stress#GO:0033554;negative regulation of intracellular signal transduction#GO:1902532;response to unfolded protein#GO:0006986;regulation of cellular response to stress#GO:0080135;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of response to stimulus#GO:0048585;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;monoatomic cation homeostasis#GO:0055080;regulation of response to stimulus#GO:0048583;macromolecule metabolic process#GO:0043170;regulation of catabolic process#GO:0009894;cellular homeostasis#GO:0019725;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;modification-dependent protein catabolic process#GO:0019941;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of cell communication#GO:0010646;regulation of ERAD pathway#GO:1904292;regulation of apoptotic signaling pathway#GO:2001233;cellular response to topologically incorrect protein#GO:0035967;negative regulation of apoptotic signaling pathway#GO:2001234;cellular process#GO:0009987;signal transduction#GO:0007165;negative regulation of programmed cell death#GO:0043069;regulation of proteasomal protein catabolic process#GO:0061136;negative regulation of signal transduction#GO:0009968;macromolecule catabolic process#GO:0009057;negative regulation of biological process#GO:0048519;intracellular monoatomic ion homeostasis#GO:0006873;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;response to topologically incorrect protein#GO:0035966;calcium ion homeostasis#GO:0055074;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;protein catabolic process#GO:0030163;negative regulation of cell communication#GO:0010648 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum membrane#GO:0005789 HUMAN|HGNC=21204|UniProtKB=Q8WWN9 Q8WWN9 IPCEF1 PTHR12844:SF45 CONNECTOR ENCHANCER OF KINASE SUPPRESSOR OF RAS CNK3_IPCEF1 FUSION PROTEIN-RELATED protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular component organization#GO:0016043;postsynapse organization#GO:0099173;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell junction organization#GO:0034330;synapse organization#GO:0050808;postsynaptic specialization organization#GO:0099084;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;signal transduction#GO:0007165;cellular process#GO:0009987;organelle organization#GO:0006996;biological regulation#GO:0065007;cell surface receptor signaling pathway#GO:0007166;cellular component organization or biogenesis#GO:0071840 membrane#GO:0016020;cell periphery#GO:0071944;glutamatergic synapse#GO:0098978;cellular anatomical structure#GO:0110165;synapse#GO:0045202;cell junction#GO:0030054;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HUMAN|HGNC=18633|UniProtKB=Q6PL24 Q6PL24 TMED8 PTHR22973:SF3 LD35087P PROTEIN TMED8 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 cellular process#GO:0009987;transport#GO:0006810;establishment of localization#GO:0051234;vesicle-mediated transport#GO:0016192;localization#GO:0051179 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;membrane#GO:0016020;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794 HUMAN|HGNC=3680|UniProtKB=Q9GZV9 Q9GZV9 FGF23 PTHR11486:SF69 FIBROBLAST GROWTH FACTOR FIBROBLAST GROWTH FACTOR 23 molecular function activator activity#GO:0140677;protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;fibroblast growth factor receptor binding#GO:0005104;growth factor receptor binding#GO:0070851;growth factor activity#GO:0008083;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018 signaling#GO:0023052;cellular response to endogenous stimulus#GO:0071495;cell differentiation#GO:0030154;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;positive regulation of cell population proliferation#GO:0008284;response to endogenous stimulus#GO:0009719;cellular response to growth factor stimulus#GO:0071363;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;animal gross anatomical part developmental process#GO:0160108;regulation of intracellular signal transduction#GO:1902531;nervous system development#GO:0007399;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular response to fibroblast growth factor stimulus#GO:0044344;cellular process#GO:0009987;multicellular organism development#GO:0007275;regulation of MAPK cascade#GO:0043408;cell surface receptor signaling pathway#GO:0007166;regulation of cell communication#GO:0010646;response to growth factor#GO:0070848;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;system development#GO:0048731;regulation of cell population proliferation#GO:0042127;regulation of cell motility#GO:2000145;cell communication#GO:0007154;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of locomotion#GO:0040012;positive regulation of response to stimulus#GO:0048584;fibroblast growth factor receptor signaling pathway#GO:0008543;multicellular organismal process#GO:0032501;positive regulation of cellular process#GO:0048522;neurogenesis#GO:0022008;positive regulation of MAPK cascade#GO:0043410;cellular developmental process#GO:0048869;developmental process#GO:0032502;regulation of cell migration#GO:0030334;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;response to fibroblast growth factor#GO:0071774 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;extracellular region#GO:0005576 growth factor#PC00112;intercellular signal molecule#PC00207 HUMAN|HGNC=6993|UniProtKB=Q02078 Q02078 MEF2A PTHR11945:SF637 MADS BOX PROTEIN MYOCYTE-SPECIFIC ENHANCER FACTOR 2A sequence-specific double-stranded DNA binding#GO:1990837;histone deacetylase binding#GO:0042826;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific DNA binding#GO:0043565;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;enzyme binding#GO:0019899;transcription regulator activity#GO:0140110;transcription regulatory region nucleic acid binding#GO:0001067;protein binding#GO:0005515 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;developmental process#GO:0032502;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA metabolic process#GO:0051252;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;positive regulation of RNA metabolic process#GO:0051254;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 MADS box transcription factor#PC00250 p38 MAPK pathway#P05918>MEF#P06023;Oxidative stress response#P00046>MEF-2#P01128 HUMAN|HGNC=29167|UniProtKB=Q9Y2K5 Q9Y2K5 R3HDM2 PTHR15672:SF13 CAMP-REGULATED PHOSPHOPROTEIN 21 RELATED R3H DOMAIN CONTAINING PROTEIN R3H DOMAIN-CONTAINING PROTEIN 2 HUMAN|HGNC=29369|UniProtKB=Q9C0B0 Q9C0B0 UNK PTHR14493:SF36 UNKEMPT FAMILY MEMBER RING FINGER PROTEIN UNKEMPT HOMOLOG RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729 cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;neurogenesis#GO:0022008;neuron differentiation#GO:0030182;developmental process#GO:0032502;multicellular organismal process#GO:0032501;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;cellular process#GO:0009987;anatomical structure development#GO:0048856;neuron development#GO:0048666;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;cell morphogenesis#GO:0000902;cell differentiation#GO:0030154;cell development#GO:0048468;anatomical structure morphogenesis#GO:0009653 HUMAN|HGNC=8803|UniProtKB=P16234 P16234 PDGFRA PTHR24416:SF52 TYROSINE-PROTEIN KINASE RECEPTOR PLATELET-DERIVED GROWTH FACTOR RECEPTOR ALPHA transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;growth factor binding#GO:0019838;protein binding#GO:0005515;kinase activity#GO:0016301;transferase activity#GO:0016740;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity, acting on a protein#GO:0140096 cellular response to stimulus#GO:0051716;animal organ morphogenesis#GO:0009887;cell motility#GO:0048870;regulation of cellular process#GO:0050794;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;embryonic organ development#GO:0048568;embryo development ending in birth or egg hatching#GO:0009792;system development#GO:0048731;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;positive regulation of cellular process#GO:0048522;skeletal system morphogenesis#GO:0048705;biological regulation#GO:0065007;cell migration#GO:0016477;multicellular organismal process#GO:0032501;developmental process#GO:0032502;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;positive regulation of cell population proliferation#GO:0008284;signaling#GO:0023052;response to stimulus#GO:0050896;animal gross anatomical part developmental process#GO:0160108;chordate embryonic development#GO:0043009;skeletal system development#GO:0001501;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;embryo development#GO:0009790;cell surface receptor signaling pathway#GO:0007166;embryonic morphogenesis#GO:0048598;multicellular organism development#GO:0007275;animal organ development#GO:0048513 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;signaling receptor complex#GO:0043235;membrane#GO:0016020 transmembrane signal receptor#PC00197 Angiogenesis#P00005>PDGFR#P00230;PDGF signaling pathway#P00047>PDGF receptor A#P01158 HUMAN|HGNC=15890|UniProtKB=Q9BY42 Q9BY42 RTF2 PTHR12775:SF0 PROTEIN C20ORF43 HOMOLOG REPLICATION TERMINATION FACTOR 2 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=21882|UniProtKB=A0AVF1 A0AVF1 IFT56 PTHR14781:SF0 INTRAFLAGELLAR TRANSPORT PROTEIN 56 INTRAFLAGELLAR TRANSPORT PROTEIN 56 binding#GO:0005488;protein-containing complex binding#GO:0044877 microtubule-based transport#GO:0099111;organelle assembly#GO:0070925;cilium organization#GO:0044782;cellular localization#GO:0051641;localization#GO:0051179;cellular component organization#GO:0016043;cilium assembly#GO:0060271;intraciliary transport#GO:0042073;microtubule-based movement#GO:0007018;cell projection organization#GO:0030030;transport#GO:0006810;intracellular transport#GO:0046907;plasma membrane bounded cell projection assembly#GO:0120031;microtubule-based process#GO:0007017;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cell projection assembly#GO:0030031;establishment of localization in cell#GO:0051649;intraciliary transport involved in cilium assembly#GO:0035735;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton-dependent intracellular transport#GO:0030705;cellular component assembly#GO:0022607 intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;ciliary base#GO:0097546;membraneless organelle#GO:0043228;intraciliary transport particle B#GO:0030992;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;ciliary basal body#GO:0036064;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cilium#GO:0005929;intraciliary transport particle#GO:0030990 HUMAN|HGNC=53851|UniProtKB=P0DW13 P0DW13 TAF11L8 PTHR13218:SF18 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11-RELATED TATA-BOX-BINDING PROTEIN-ASSOCIATED FACTOR 11-LIKE PROTEIN 10-RELATED cellular component biogenesis#GO:0044085;transcription initiation at RNA polymerase II promoter#GO:0006367;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;cellular component assembly#GO:0022607;protein-DNA complex assembly#GO:0065004;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;transcription by RNA polymerase II#GO:0006366;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-DNA complex organization#GO:0071824;protein-containing complex organization#GO:0043933;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;DNA-templated transcription initiation#GO:0006352;RNA polymerase II preinitiation complex assembly#GO:0051123;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070 RNA polymerase II, holoenzyme#GO:0016591;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;transcription regulator complex#GO:0005667;transferase complex#GO:1990234;protein-containing complex#GO:0032991;transcription factor TFIID complex#GO:0005669;RNA polymerase II transcription regulator complex#GO:0090575;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;RNA polymerase complex#GO:0030880 RNA metabolism protein#PC00031;general transcription factor#PC00259 HUMAN|HGNC=18268|UniProtKB=Q6UX01 Q6UX01 LMBR1L PTHR12625:SF2 LIPOCALIN-1 INTERACTING MEMBRANE RECEPTOR LIMR PROTEIN LMBR1L transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 biological regulation#GO:0065007;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;signal transduction#GO:0007165;receptor-mediated endocytosis#GO:0006898;import into cell#GO:0098657;establishment of localization#GO:0051234;transport#GO:0006810;signaling#GO:0023052;endocytosis#GO:0006897;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cell communication#GO:0007154;localization#GO:0051179 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=9667|UniProtKB=Q14761 Q14761 PTPRCAP PTHR15312:SF1 PROTEIN TYROSINE PHOSPHATASE RECEPTOR TYPE C-ASSOCIATED PROTEIN PROTEIN TYROSINE PHOSPHATASE RECEPTOR TYPE C-ASSOCIATED PROTEIN plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=12563|UniProtKB=P11172 P11172 UMPS PTHR19278:SF9 OROTATE PHOSPHORIBOSYLTRANSFERASE URIDINE 5'-MONOPHOSPHATE SYNTHASE glycosyltransferase activity#GO:0016757;lyase activity#GO:0016829;pentosyltransferase activity#GO:0016763;carbon-carbon lyase activity#GO:0016830;transferase activity#GO:0016740;catalytic activity#GO:0003824;carboxy-lyase activity#GO:0016831 primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;small molecule metabolic process#GO:0044281;nucleoside monophosphate metabolic process#GO:0009123;nucleoside phosphate metabolic process#GO:0006753;nucleoside monophosphate biosynthetic process#GO:0009124;ribonucleotide metabolic process#GO:0009259;nucleotide metabolic process#GO:0009117;organophosphate biosynthetic process#GO:0090407;nucleotide biosynthetic process#GO:0009165;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;ribose phosphate biosynthetic process#GO:0046390;carbohydrate derivative metabolic process#GO:1901135;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;pyrimidine-containing compound metabolic process#GO:0072527;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleoside phosphate biosynthetic process#GO:1901293;pyrimidine nucleobase metabolic process#GO:0006206;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;nucleobase metabolic process#GO:0009112 transferase#PC00220;metabolite interconversion enzyme#PC00262 De novo pyrimidine ribonucleotides biosythesis#P02740>Orotate phosphoribosyltransferase#P02922 HUMAN|HGNC=24292|UniProtKB=Q8N6G5 Q8N6G5 CSGALNACT2 PTHR12369:SF20 CHONDROITIN SYNTHASE CHONDROITIN SULFATE N-ACETYLGALACTOSAMINYLTRANSFERASE 2 hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;acetylgalactosaminyltransferase activity#GO:0008376;UDP-glycosyltransferase activity#GO:0008194 proteoglycan biosynthetic process#GO:0030166;biosynthetic process#GO:0009058;chondroitin sulfate proteoglycan biosynthetic process#GO:0050650;glycoprotein biosynthetic process#GO:0009101;carbohydrate derivative metabolic process#GO:1901135;chondroitin sulfate proteoglycan metabolic process#GO:0050654;cellular process#GO:0009987;protein O-linked glycosylation#GO:0006493;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;proteoglycan metabolic process#GO:0006029;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538 glycosyltransferase#PC00111 HUMAN|HGNC=15011|UniProtKB=Q8NG80 Q8NG80 OR2L5 PTHR26453:SF166 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2L5 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;response to chemical#GO:0042221;response to stimulus#GO:0050896;detection of chemical stimulus#GO:0009593;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;system process#GO:0003008;nervous system process#GO:0050877;sensory perception#GO:0007600;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=30376|UniProtKB=Q8N114 Q8N114 SHISA5 PTHR31395:SF14 SHISA PROTEIN SHISA-5 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 scaffold/adaptor protein#PC00226 HUMAN|HGNC=607|UniProtKB=P02654 P02654 APOC1 PTHR16565:SF2 APOLIPOPROTEIN C-I APOLIPOPROTEIN C-I organic acid binding#GO:0043177;binding#GO:0005488;carboxylic acid binding#GO:0031406;small molecule binding#GO:0036094;anion binding#GO:0043168;ion binding#GO:0043167;molecular function inhibitor activity#GO:0140678;lipid binding#GO:0008289;enzyme regulator activity#GO:0030234;fatty acid binding#GO:0005504;enzyme inhibitor activity#GO:0004857;molecular function regulator activity#GO:0098772 regulation of lipid metabolic process#GO:0019216;negative regulation of catabolic process#GO:0009895;regulation of lipid catabolic process#GO:0050994;regulation of biological process#GO:0050789;primary metabolic process#GO:0044238;negative regulation of biological process#GO:0048519;negative regulation of multicellular organismal process#GO:0051241;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;glycerolipid metabolic process#GO:0046486;negative regulation of transport#GO:0051051;triglyceride metabolic process#GO:0006641;lipid metabolic process#GO:0006629;negative regulation of cellular process#GO:0048523;acylglycerol metabolic process#GO:0006639;metabolic process#GO:0008152;regulation of catabolic process#GO:0009894;regulation of transport#GO:0051049;regulation of localization#GO:0032879;plasma lipoprotein particle clearance#GO:0034381;neutral lipid metabolic process#GO:0006638;cellular process#GO:0009987;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;multicellular organismal process#GO:0032501 lipoprotein particle#GO:1990777;protein-lipid complex#GO:0032994;extracellular protein-containing complex#GO:0140392;extracellular region#GO:0005576;high-density lipoprotein particle#GO:0034364;plasma lipoprotein particle#GO:0034358;very-low-density lipoprotein particle#GO:0034361;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 apolipoprotein#PC00052;transfer/carrier protein#PC00219 HUMAN|HGNC=30676|UniProtKB=Q8WU76 Q8WU76 SCFD2 PTHR11679:SF71 VESICLE PROTEIN SORTING-ASSOCIATED SEC1 FAMILY DOMAIN-CONTAINING PROTEIN 2 intracellular protein localization#GO:0008104;protein transport#GO:0015031;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;vesicle-mediated transport#GO:0016192;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule localization#GO:0033036 membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=463|UniProtKB=Q9UKV5 Q9UKV5 AMFR PTHR15067:SF5 E3 UBIQUITIN-PROTEIN LIGASE RNF8 E3 UBIQUITIN-PROTEIN LIGASE AMFR aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746 response to stimulus#GO:0050896;response to topologically incorrect protein#GO:0035966;signaling#GO:0023052;regulation of biological process#GO:0050789;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;response to unfolded protein#GO:0006986;protein modification by small protein conjugation or removal#GO:0070647;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;protein ubiquitination#GO:0016567;response to stress#GO:0006950;cellular process#GO:0009987;signal transduction#GO:0007165;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;protein modification process#GO:0036211;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;modification-dependent protein catabolic process#GO:0019941;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular response to unfolded protein#GO:0034620;response to endoplasmic reticulum stress#GO:0034976;cellular response to topologically incorrect protein#GO:0035967;post-translational protein modification#GO:0043687;biological regulation#GO:0065007;endoplasmic reticulum unfolded protein response#GO:0030968;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;protein K48-linked ubiquitination#GO:0070936 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex#GO:1990234;endoplasmic reticulum#GO:0005783;ubiquitin ligase complex#GO:0000151;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=18155|UniProtKB=Q9NNW7 Q9NNW7 TXNRD2 PTHR48105:SF21 THIOREDOXIN REDUCTASE 1-RELATED-RELATED THIOREDOXIN REDUCTASE 2, MITOCHONDRIAL antioxidant activity#GO:0016209;catalytic activity#GO:0003824;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;protein-disulfide reductase activity#GO:0015035;oxidoreductase activity#GO:0016491;catalytic activity, acting on a protein#GO:0140096;disulfide oxidoreductase activity#GO:0015036 cellular homeostasis#GO:0019725;homeostatic process#GO:0042592;cell redox homeostasis#GO:0045454 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;cytosol#GO:0005829 reductase#PC00198;oxidoreductase#PC00176 HUMAN|HGNC=31293|UniProtKB=A6NF89 A6NF89 OR6C6 PTHR26454:SF40 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 6C6 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=2267|UniProtKB=P20674 P20674 COX5A PTHR14200:SF16 CYTOCHROME C OXIDASE POLYPEPTIDE CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL mitochondrial ATP synthesis coupled electron transport#GO:0042775;cellular process#GO:0009987;respiratory electron transport chain#GO:0022904;electron transport chain#GO:0022900;generation of precursor metabolites and energy#GO:0006091;metabolic process#GO:0008152;aerobic electron transport chain#GO:0019646;mitochondrial electron transport, cytochrome c to oxygen#GO:0006123;aerobic respiration#GO:0009060;ATP synthesis coupled electron transport#GO:0042773;oxidative phosphorylation#GO:0006119;cellular respiration#GO:0045333;energy derivation by oxidation of organic compounds#GO:0015980 catalytic complex#GO:1902494;transmembrane transporter complex#GO:1902495;respiratory chain complex IV#GO:0045277;transporter complex#GO:1990351;membrane protein complex#GO:0098796;membrane#GO:0016020;oxidoreductase complex#GO:1990204;cytochrome complex#GO:0070069;respiratory chain complex#GO:0098803;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 oxidase#PC00175;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=19949|UniProtKB=O75817 O75817 POP7 PTHR15314:SF1 RIBONUCLEASE P PROTEIN SUBUNIT P20 RIBONUCLEASE P PROTEIN SUBUNIT P20 RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031;endoribonuclease#PC00094 HUMAN|HGNC=26999|UniProtKB=Q6ZMY6 Q6ZMY6 WDR88 PTHR45048:SF1 FAMILY NOT NAMED WD REPEAT-CONTAINING PROTEIN 88 HUMAN|HGNC=16356|UniProtKB=Q495M9 Q495M9 USH1G PTHR24161:SF24 ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED PRE-MRNA SPLICING REGULATOR USH1G nervous system process#GO:0050877;sensory perception#GO:0007600;sensory perception of mechanical stimulus#GO:0050954;sensory perception of light stimulus#GO:0050953;system process#GO:0003008;multicellular organismal process#GO:0032501;sensory perception of sound#GO:0007605 cilium#GO:0005929;photoreceptor inner segment#GO:0001917;non-motile cilium#GO:0097730;membrane-bounded organelle#GO:0043227;photoreceptor cell cilium#GO:0097733;neuron projection#GO:0043005;9+0 non-motile cilium#GO:0097731;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226 protein modifying enzyme#PC00260 HUMAN|HGNC=15152|UniProtKB=Q8NGL6 Q8NGL6 OR4A15 PTHR48002:SF79 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 4A15 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=7002|UniProtKB=A6NDR6 A6NDR6 MEIS3P1 PTHR11850:SF332 HOMEOBOX PROTEIN TRANSCRIPTION FACTORS HOMEOBOX PROTEIN MEIS3-LIKE 1-RELATED binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription activator activity#GO:0001216;transcription regulator activity#GO:0140110;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837 animal organ development#GO:0048513;multicellular organism development#GO:0007275;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of macromolecule metabolic process#GO:0010604;embryo development#GO:0009790;nervous system development#GO:0007399;head development#GO:0060322;sensory system development#GO:0048880;embryonic pattern specification#GO:0009880;positive regulation of biological process#GO:0048518;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;eye development#GO:0001654;animal gross anatomical part developmental process#GO:0160108;regulation of transcription by RNA polymerase II#GO:0006357;central nervous system development#GO:0007417;positive regulation of cell population proliferation#GO:0008284;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;sensory organ development#GO:0007423;developmental process#GO:0032502;multicellular organismal process#GO:0032501;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;brain development#GO:0007420;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of cell population proliferation#GO:0042127;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;pattern specification process#GO:0007389;regulation of cellular process#GO:0050794;animal organ morphogenesis#GO:0009887;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;visual system development#GO:0150063 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116;DNA-binding transcription factor#PC00218 HUMAN|HGNC=19834|UniProtKB=Q4W4Y0 Q4W4Y0 DORIP1 PTHR35350:SF1 HYPOTHETICAL LOC314168 DOPAMINE RECEPTOR-INTERACTING PROTEIN 1 HUMAN|HGNC=52388|UniProtKB=A0A1B0GTK4 A0A1B0GTK4 FAM237A PTHR36690:SF2 PROTEIN FAM237A PROTEIN FAM237A HUMAN|HGNC=25605|UniProtKB=Q96HH6 Q96HH6 TMEM19 PTHR13353:SF5 TRANSMEMBRANE PROTEIN 19 TRANSMEMBRANE PROTEIN 19 cellular anatomical structure#GO:0110165;membrane#GO:0016020 HUMAN|HGNC=904|UniProtKB=Q9Y2T1 Q9Y2T1 AXIN2 PTHR46102:SF1 AXIN AXIN-2 ubiquitin-like protein ligase binding#GO:0044389;ubiquitin protein ligase binding#GO:0031625;binding#GO:0005488;kinase binding#GO:0019900;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;protein binding#GO:0005515;beta-catenin binding#GO:0008013 positive regulation of protein catabolic process#GO:0045732;regulation of protein catabolic process#GO:0042176;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434;anatomical structure development#GO:0048856;positive regulation of ubiquitin-dependent protein catabolic process#GO:2000060;regulation of cell communication#GO:0010646;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;developmental process#GO:0032502;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;regulation of chromosome organization#GO:0033044;regulation of catabolic process#GO:0009894;cellular developmental process#GO:0048869;positive regulation of catabolic process#GO:0009896;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of response to stimulus#GO:0048585;negative regulation of Wnt signaling pathway#GO:0030178;positive regulation of protein metabolic process#GO:0051247;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;negative regulation of canonical Wnt signaling pathway#GO:0090090;negative regulation of cell communication#GO:0010648;positive regulation of metabolic process#GO:0009893;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;negative regulation of biological process#GO:0048519;positive regulation of proteasomal protein catabolic process#GO:1901800;regulation of cell cycle#GO:0051726;regulation of Wnt signaling pathway#GO:0030111;cell development#GO:0048468;regulation of cellular component organization#GO:0051128;cell differentiation#GO:0030154;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of protein metabolic process#GO:0051246;regulation of canonical Wnt signaling pathway#GO:0060828;regulation of cell cycle process#GO:0010564;positive regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032436;negative regulation of signal transduction#GO:0009968;positive regulation of macromolecule metabolic process#GO:0010604;regulation of proteasomal protein catabolic process#GO:0061136 membrane#GO:0016020;nucleus#GO:0005634;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;plasma membrane#GO:0005886;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 scaffold/adaptor protein#PC00226 Wnt signaling pathway#P00057>Wnt Target Genes#G01558;Angiogenesis#P00005>Axin#P00253;Wnt signaling pathway#P00057>Axin#P01429 HUMAN|HGNC=6971|UniProtKB=P40926 P40926 MDH2 PTHR11540:SF76 MALATE AND LACTATE DEHYDROGENASE MALATE DEHYDROGENASE, MITOCHONDRIAL oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 cellular process#GO:0009987;primary metabolic process#GO:0044238;tricarboxylic acid cycle#GO:0006099;generation of precursor metabolites and energy#GO:0006091;metabolic process#GO:0008152;aerobic respiration#GO:0009060;cellular respiration#GO:0045333;energy derivation by oxidation of organic compounds#GO:0015980 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739 dehydrogenase#PC00092 HUMAN|HGNC=16768|UniProtKB=O60391 O60391 GRIN3B PTHR18966:SF364 IONOTROPIC GLUTAMATE RECEPTOR GLUTAMATE RECEPTOR IONOTROPIC, NMDA 3B signaling receptor activity#GO:0038023;monoatomic ion channel activity#GO:0005216;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;amino acid transmembrane transporter activity#GO:0015171;neurotransmitter receptor activity#GO:0030594;voltage-gated channel activity#GO:0022832;gated channel activity#GO:0022836;transmembrane signaling receptor activity#GO:0004888;voltage-gated monoatomic ion channel activity#GO:0005244;dicarboxylic acid transmembrane transporter activity#GO:0005310;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;transmembrane transporter activity#GO:0022857;glutamate receptor activity#GO:0008066;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;channel activity#GO:0015267;molecular transducer activity#GO:0060089;ligand-gated monoatomic ion channel activity#GO:0015276;carboxylic acid transmembrane transporter activity#GO:0046943 regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;response to stimulus#GO:0050896;regulation of cell communication#GO:0010646;modulation of chemical synaptic transmission#GO:0050804;signaling#GO:0023052;chemical synaptic transmission#GO:0007268;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cell communication#GO:0007154;glutamate receptor signaling pathway#GO:0007215;trans-synaptic signaling#GO:0099537;regulation of signaling#GO:0023051;regulation of trans-synaptic signaling#GO:0099177;cell-cell signaling#GO:0007267;synaptic transmission, glutamatergic#GO:0035249;biological regulation#GO:0065007;synaptic signaling#GO:0099536;cellular process#GO:0009987;signal transduction#GO:0007165;cell surface receptor signaling pathway#GO:0007166 postsynapse#GO:0098794;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;asymmetric synapse#GO:0032279;postsynaptic density#GO:0014069;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;postsynaptic density membrane#GO:0098839;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;neuron to neuron synapse#GO:0098984;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;synaptic membrane#GO:0097060;cell junction#GO:0030054 transmembrane signal receptor#PC00197 Metabotropic glutamate receptor group III pathway#P00039>NMDA#P01039;Ionotropic glutamate receptor pathway#P00037>NR3#P01009;Huntington disease#P00029>NMDA receptor#P00778;Metabotropic glutamate receptor group I pathway#P00041>NMDA#P01060;Ionotropic glutamate receptor pathway#P00037>NMDA#P01024;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>NMDA#P01071 HUMAN|HGNC=22974|UniProtKB=Q8N4G2 Q8N4G2 ARL14 PTHR11711:SF29 ADP RIBOSYLATION FACTOR-RELATED ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 14 guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;guanyl nucleotide binding#GO:0019001;ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;small molecule binding#GO:0036094;anion binding#GO:0043168;nucleotide binding#GO:0000166;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076 establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;protein transport#GO:0015031;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810;vesicle-mediated transport#GO:0016192;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 G-protein#PC00020 HUMAN|HGNC=10315|UniProtKB=P35268 P35268 RPL22 PTHR10064:SF2 60S RIBOSOMAL PROTEIN L22 LARGE RIBOSOMAL SUBUNIT PROTEIN EL22 binding#GO:0005488;structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;structural molecule activity#GO:0005198 biosynthetic process#GO:0009058;cytoplasmic translation#GO:0002181;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;translation#GO:0006412;metabolic process#GO:0008152 ribosomal protein#PC00202 HUMAN|HGNC=17087|UniProtKB=O75144 O75144 ICOSLG PTHR24100:SF159 BUTYROPHILIN ICOS LIGAND protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488 positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of cytokine production#GO:0001817;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;T cell receptor signaling pathway#GO:0050852;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of macromolecule metabolic process#GO:0060255;immune response-activating cell surface receptor signaling pathway#GO:0002429;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;regulation of immune response#GO:0050776;antigen receptor-mediated signaling pathway#GO:0050851;regulation of multicellular organismal process#GO:0051239;positive regulation of immune system process#GO:0002684;cellular process#GO:0009987;activation of immune response#GO:0002253;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;immune response-activating signaling pathway#GO:0002757;cell surface receptor signaling pathway#GO:0007166;response to stimulus#GO:0050896;signaling#GO:0023052;immune response-regulating signaling pathway#GO:0002764;regulation of biological process#GO:0050789;immune system process#GO:0002376 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell surface#GO:0009986;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;membrane#GO:0016020 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=8945|UniProtKB=O75830 O75830 SERPINI2 PTHR11461:SF51 SERINE PROTEASE INHIBITOR, SERPIN SERPIN I2 enzyme inhibitor activity#GO:0004857;endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414;peptidase regulator activity#GO:0061134;enzyme regulator activity#GO:0030234;serine-type endopeptidase inhibitor activity#GO:0004867;molecular function inhibitor activity#GO:0140678 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HUMAN|HGNC=34345|UniProtKB=Q6PIY5 Q6PIY5 ARMH1 PTHR34258:SF1 ARMADILLO-LIKE HELICAL DOMAIN CONTAINING PROTEIN 1 ARMADILLO-LIKE HELICAL DOMAIN CONTAINING PROTEIN 1 HUMAN|HGNC=16884|UniProtKB=Q8N5H7 Q8N5H7 SH2D3C PTHR14247:SF6 BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3 HOMOLOG-LIKE PROTEIN SH2 DOMAIN-CONTAINING PROTEIN 3C HUMAN|HGNC=2981|UniProtKB=Q9ULA0 Q9ULA0 DNPEP PTHR28570:SF18 ASPARTYL AMINOPEPTIDASE ASPARTYL AMINOPEPTIDASE metalloexopeptidase activity#GO:0008235;aminopeptidase activity#GO:0004177;catalytic activity#GO:0003824;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;metallopeptidase activity#GO:0008237;hydrolase activity#GO:0016787;metalloaminopeptidase activity#GO:0070006;exopeptidase activity#GO:0008238 primary metabolic process#GO:0044238;proteolysis#GO:0006508;metabolic process#GO:0008152;cellular process#GO:0009987;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 metalloprotease#PC00153;protein modifying enzyme#PC00260;protease#PC00190 HUMAN|HGNC=1346|UniProtKB=P10643 P10643 C7 PTHR45742:SF2 COMPLEMENT COMPONENT C6 COMPLEMENT COMPONENT C7 regulation of biological process#GO:0050789;regulation of immune system process#GO:0002682;response to stimulus#GO:0050896;regulation of immune response#GO:0050776;immune system process#GO:0002376;immune response#GO:0006955;complement activation#GO:0006956;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;positive regulation of immune system process#GO:0002684;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;immune effector process#GO:0002252;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;humoral immune response#GO:0006959 extracellular region#GO:0005576;membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886 complement component#PC00078 HUMAN|HGNC=11573|UniProtKB=P17735 P17735 TAT PTHR45744:SF46 TYROSINE AMINOTRANSFERASE TYROSINE AMINOTRANSFERASE transaminase activity#GO:0008483;catalytic activity#GO:0003824;transferase activity#GO:0016740 cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;small molecule catabolic process#GO:0044282;amino acid metabolic process#GO:0006520;proteinogenic amino acid metabolic process#GO:0170039;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152 transaminase#PC00216 Tyrosine biosynthesis#P02784>Aromatic amino acid aminotransferase#P03213 HUMAN|HGNC=407|UniProtKB=P30837 P30837 ALDH1B1 PTHR11699:SF207 ALDEHYDE DEHYDROGENASE-RELATED ALDEHYDE DEHYDROGENASE FAMILY 1 MEMBER B1, MITOCHONDRIAL oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the aldehyde or oxo group of donors#GO:0016903;catalytic activity#GO:0003824;aldehyde dehydrogenase (NAD+) activity#GO:0004029;oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor#GO:0016620 metabolic process#GO:0008152;aldehyde metabolic process#GO:0006081;cellular process#GO:0009987;catabolic process#GO:0009056;aldehyde catabolic process#GO:0046185 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 5-Hydroxytryptamine degredation#P04372>Aldehyde Dehydrogenase#P04402 HUMAN|HGNC=25100|UniProtKB=Q9BVM4 Q9BVM4 GGACT PTHR12510:SF4 TROPONIN C-AKIN-1 PROTEIN GAMMA-GLUTAMYLAMINECYCLOTRANSFERASE intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 HUMAN|HGNC=13578|UniProtKB=Q5VUA4 Q5VUA4 ZNF318 PTHR15577:SF2 ZINC FINGER CONTAINING PROTEIN ZINC FINGER PROTEIN 318 negative regulation of DNA-templated transcription#GO:0045892;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of metabolic process#GO:0009892;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of macromolecule biosynthetic process#GO:0010558;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;negative regulation of cellular process#GO:0048523;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=25106|UniProtKB=A4D1E9 A4D1E9 GTPBP10 PTHR11702:SF43 DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN-RELATED GTP-BINDING PROTEIN 10 pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;GTPase activity#GO:0003924;ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;guanyl nucleotide binding#GO:0019001;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HUMAN|HGNC=30201|UniProtKB=Q9Y6G5 Q9Y6G5 COMMD10 PTHR12333:SF0 COMM DOMAIN CONTAINING PROTEIN 10 COMM DOMAIN-CONTAINING PROTEIN 10 protein complex scaffold activity#GO:0140378;structural molecule activity#GO:0005198 protein-containing complex#GO:0032991 HUMAN|HGNC=9834|UniProtKB=Q7Z5J4 Q7Z5J4 RAI1 PTHR14955:SF6 RETINOIC ACID INDUCED 1/TRANSCRIPTION FACTOR 20 RETINOIC ACID-INDUCED PROTEIN 1 transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 circadian regulation of gene expression#GO:0032922;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;rhythmic process#GO:0048511;regulation of DNA-templated transcription#GO:0006355;circadian rhythm#GO:0007623;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 zinc finger transcription factor#PC00244 HUMAN|HGNC=3271|UniProtKB=Q14152 Q14152 EIF3A PTHR14005:SF0 EUKARYOTIC TRANSLATION INITIATION FACTOR 3, THETA SUBUNIT EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT A translation factor activity#GO:0180051;translation initiation factor activity#GO:0003743 ribonucleoprotein complex biogenesis#GO:0022613;protein biosynthetic process#GO:0160307;cytoplasmic translation#GO:0002181;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;protein-RNA complex assembly#GO:0022618;translational initiation#GO:0006413;translation#GO:0006412;cytoplasmic translational initiation#GO:0002183;biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular component assembly#GO:0022607;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;protein-containing complex organization#GO:0043933;protein-RNA complex organization#GO:0071826;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152 cytosol#GO:0005829;eukaryotic translation initiation factor 3 complex#GO:0005852;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 translation initiation factor#PC00224 HUMAN|HGNC=24542|UniProtKB=Q9BVM2 Q9BVM2 DPCD PTHR31921:SF1 PROTEIN DPCD PROTEIN DPCD molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of plasma membrane bounded cell projection assembly#GO:0120032;regulation of cellular component biogenesis#GO:0044087;biological regulation#GO:0065007;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of organelle assembly#GO:1902115;regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of cell projection assembly#GO:0060491;regulation of cilium assembly#GO:1902017;regulation of cell projection organization#GO:0031344 intracellular organelle#GO:0043229;centrosome#GO:0005813;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=22197|UniProtKB=O43299 O43299 AP5Z1 PTHR46488:SF1 AP-5 COMPLEX SUBUNIT ZETA-1 AP-5 COMPLEX SUBUNIT ZETA-1 HUMAN|HGNC=11306|UniProtKB=P78362 P78362 SRPK2 PTHR47634:SF6 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED SRSF PROTEIN KINASE 2 catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 regulation of RNA metabolic process#GO:0051252;intracellular signal transduction#GO:0035556;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;protein-RNA complex assembly#GO:0022618;cell communication#GO:0007154;RNA splicing, via transesterification reactions#GO:0000375;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;macromolecule metabolic process#GO:0043170;biosynthetic process#GO:0009058;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;regulation of mRNA processing#GO:0050684;regulation of nucleobase-containing compound metabolic process#GO:0019219;macromolecule biosynthetic process#GO:0009059;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;RNA metabolic process#GO:0016070;spliceosomal complex assembly#GO:0000245;nucleic acid biosynthetic process#GO:0141187;ribonucleoprotein complex biogenesis#GO:0022613;signaling#GO:0023052;mRNA metabolic process#GO:0016071;response to stimulus#GO:0050896;protein-containing complex assembly#GO:0065003;regulation of biological process#GO:0050789;mRNA splicing, via spliceosome#GO:0000398;cellular component organization#GO:0016043;protein-containing complex organization#GO:0043933;protein-RNA complex organization#GO:0071826;regulation of mRNA metabolic process#GO:1903311;cellular component organization or biogenesis#GO:0071840;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA processing#GO:0006396;gene expression#GO:0010467;cellular component assembly#GO:0022607;cellular process#GO:0009987;signal transduction#GO:0007165;mRNA processing#GO:0006397;cellular component biogenesis#GO:0044085 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=32422|UniProtKB=Q8N4K4 Q8N4K4 RPRML PTHR28649:SF3 PROTEIN REPRIMO-RELATED REPRIMO-LIKE PROTEIN HUMAN|HGNC=8776|UniProtKB=Q14123 Q14123 PDE1C PTHR11347:SF32 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE DUAL SPECIFICITY CALCIUM_CALMODULIN-DEPENDENT 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 1C hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;cyclic-nucleotide phosphodiesterase activity#GO:0004112;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;phosphoric diester hydrolase activity#GO:0008081 negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;regulation of intracellular signal transduction#GO:1902531;negative regulation of cellular process#GO:0048523;negative regulation of signaling#GO:0023057;negative regulation of signal transduction#GO:0009968;regulation of cell communication#GO:0010646;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of response to stimulus#GO:0048585;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519 cell body#GO:0044297;cellular anatomical structure#GO:0110165;neuronal cell body#GO:0043025;somatodendritic compartment#GO:0036477 hydrolase#PC00121;phosphodiesterase#PC00185 HUMAN|HGNC=7606|UniProtKB=Q13402 Q13402 MYO7A PTHR13140:SF369 MYOSIN UNCONVENTIONAL MYOSIN-VIIA cytoskeletal motor activity#GO:0003774;isomerase activity#GO:0016853;catalytic activity#GO:0003824;polypeptide conformation or assembly isomerase activity#GO:0120544;microfilament motor activity#GO:0000146;macromolecular conformation isomerase activity#GO:0120543;ATP-dependent activity#GO:0140657 supramolecular fiber organization#GO:0097435;anatomical structure development#GO:0048856;sensory perception#GO:0007600;sensory perception of mechanical stimulus#GO:0050954;actin filament-based process#GO:0030029;nervous system process#GO:0050877;animal gross anatomical part developmental process#GO:0160108;sensory perception of sound#GO:0007605;actin cytoskeleton organization#GO:0030036;cellular component organization#GO:0016043;actin filament organization#GO:0007015;system process#GO:0003008;cellular component organization or biogenesis#GO:0071840;animal organ development#GO:0048513;developmental process#GO:0032502;sensory organ development#GO:0007423;cytoskeleton organization#GO:0007010;multicellular organismal process#GO:0032501;cellular process#GO:0009987;actin filament-based movement#GO:0030048;organelle organization#GO:0006996 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;actin cytoskeleton#GO:0015629;membrane#GO:0016020;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 actin binding motor protein#PC00040 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HUMAN|HGNC=22265|UniProtKB=Q7RTS1 Q7RTS1 BHLHA15 PTHR19290:SF160 BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED CLASS A BASIC HELIX-LOOP-HELIX PROTEIN 15 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;sensory organ development#GO:0007423;developmental process#GO:0032502;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;axon development#GO:0061564;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of cellular process#GO:0048522;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;neuron development#GO:0048666;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;cell projection organization#GO:0030030;cell development#GO:0048468;positive regulation of transcription by RNA polymerase II#GO:0045944;neuron differentiation#GO:0030182;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;animal organ development#GO:0048513;neuron projection development#GO:0031175;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;nervous system development#GO:0007399 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=5155|UniProtKB=P05981 P05981 HPN PTHR24253:SF166 TRANSMEMBRANE PROTEASE SERINE SERINE PROTEASE HEPSIN catalytic activity#GO:0003824;serine-type peptidase activity#GO:0008236;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;serine hydrolase activity#GO:0017171 gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;protein processing#GO:0016485;cellular process#GO:0009987;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;proteolysis#GO:0006508 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 protein modifying enzyme#PC00260;protease#PC00190;serine protease#PC00203 HUMAN|HGNC=20601|UniProtKB=Q6PIS1 Q6PIS1 SLC23A3 PTHR11119:SF57 XANTHINE-URACIL / VITAMIN C PERMEASE FAMILY MEMBER SOLUTE CARRIER FAMILY 23 MEMBER 3 transporter#PC00227 HUMAN|HGNC=24884|UniProtKB=Q8TDS5 Q8TDS5 OXER1 PTHR46048:SF1 HYDROXYCARBOXYLIC ACID RECEPTOR 2 OXOEICOSANOID RECEPTOR 1 G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|Gene=YJ016_HUMAN|UniProtKB=Q499Y3 Q499Y3 PTHR14787:SF2 C10ORF188 FAMILY MEMBER SUBFAMILY NOT NAMED ATP hydrolysis activity#GO:0016887;hydrolase activity#GO:0016787;ATP-dependent activity#GO:0140657;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739 HUMAN|HGNC=18430|UniProtKB=Q96A28 Q96A28 SLAMF9 PTHR12080:SF18 SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE SLAM FAMILY MEMBER 9 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 signal transduction#GO:0007165;immune response#GO:0006955;cellular process#GO:0009987;biological regulation#GO:0065007;lymphocyte activation#GO:0046649;multicellular organismal process#GO:0032501;cell activation#GO:0001775;immune system process#GO:0002376;cell communication#GO:0007154;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;leukocyte activation#GO:0045321;T cell activation#GO:0042110;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=28568|UniProtKB=O43247 O43247 CIMIP4 PTHR31702:SF2 TESTIS-EXPRESSED PROTEIN 33 CILIARY MICROTUBULE INNER PROTEIN 4 HUMAN|HGNC=8782|UniProtKB=Q08493 Q08493 PDE4C PTHR11347:SF135 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 3',5'-CYCLIC-AMP PHOSPHODIESTERASE 4C cyclic-nucleotide phosphodiesterase activity#GO:0004112;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;phosphoric diester hydrolase activity#GO:0008081;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;negative regulation of response to stimulus#GO:0048585;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cell communication#GO:0010646;negative regulation of signal transduction#GO:0009968;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648 phosphodiesterase#PC00185;hydrolase#PC00121 HUMAN|HGNC=11277|UniProtKB=O15269 O15269 SPTLC1 PTHR13693:SF2 CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE SERINE PALMITOYLTRANSFERASE 1 transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746;palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 sphingoid biosynthetic process#GO:0046520;ceramide metabolic process#GO:0006672;ceramide biosynthetic process#GO:0046513;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;sphingolipid biosynthetic process#GO:0030148;alcohol metabolic process#GO:0006066;biosynthetic process#GO:0009058;small molecule metabolic process#GO:0044281;lipid biosynthetic process#GO:0008610;alcohol biosynthetic process#GO:0046165;cellular process#GO:0009987;primary metabolic process#GO:0044238 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 transaminase#PC00216 HUMAN|HGNC=17014|UniProtKB=Q00587 Q00587 CDC42EP1 PTHR15344:SF7 CDC42 EFFECTOR PROTEIN BORG CDC42 EFFECTOR PROTEIN 1 binding#GO:0005488;enzyme binding#GO:0019899;protein binding#GO:0005515;small GTPase binding#GO:0031267 signaling#GO:0023052;regulation of cellular component biogenesis#GO:0044087;regulation of cellular component organization#GO:0051128;regulation of plasma membrane bounded cell projection assembly#GO:0120032;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;regulation of cellular component size#GO:0032535;regulation of cell shape#GO:0008360;regulation of organelle organization#GO:0033043;regulation of protein-containing complex assembly#GO:0043254;cellular component organization#GO:0016043;regulation of biological quality#GO:0065008;positive regulation of organelle organization#GO:0010638;Rho protein signal transduction#GO:0007266;regulation of actin filament length#GO:0030832;positive regulation of cellular component organization#GO:0051130;intracellular signaling cassette#GO:0141124;regulation of actin cytoskeleton organization#GO:0032956;positive regulation of cellular component biogenesis#GO:0044089;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;regulation of anatomical structure morphogenesis#GO:0022603;regulation of anatomical structure size#GO:0090066;regulation of developmental process#GO:0050793;regulation of cytoskeleton organization#GO:0051493;regulation of protein polymerization#GO:0032271;regulation of cellular process#GO:0050794;regulation of supramolecular fiber organization#GO:1902903;cellular response to stimulus#GO:0051716;regulation of cell projection assembly#GO:0060491;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;positive regulation of cell projection organization#GO:0031346;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;regulation of actin polymerization or depolymerization#GO:0008064;regulation of actin filament polymerization#GO:0030833;positive regulation of protein polymerization#GO:0032273;positive regulation of cellular process#GO:0048522;regulation of actin filament organization#GO:0110053;regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of cell projection organization#GO:0031344;regulation of actin filament-based process#GO:0032970 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HUMAN|HGNC=382|UniProtKB=O60218 O60218 AKR1B10 PTHR11732:SF278 ALDO/KETO REDUCTASE ALDO-KETO REDUCTASE FAMILY 1 MEMBER B10 oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;alcohol dehydrogenase (NADP+) activity#GO:0008106;oxidoreductase activity#GO:0016491;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 reductase#PC00198;oxidoreductase#PC00176 HUMAN|HGNC=15766|UniProtKB=Q9H2P0 Q9H2P0 ADNP PTHR15740:SF1 NEUROPROTECTIVE PEPTIDE-CONTAINING PROTEIN ACTIVITY-DEPENDENT NEUROPROTECTOR HOMEOBOX PROTEIN regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=18072|UniProtKB=Q5HYI8 Q5HYI8 RABL3 PTHR24073:SF128 DRAB5-RELATED RAB-LIKE PROTEIN 3 ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818 transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;protein transport#GO:0015031;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;macromolecule localization#GO:0033036 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 G-protein#PC00020;small GTPase#PC00208 HUMAN|HGNC=12440|UniProtKB=P29597 P29597 TYK2 PTHR45807:SF6 TYROSINE-PROTEIN KINASE HOPSCOTCH NON-RECEPTOR TYROSINE-PROTEIN KINASE TYK2 signaling receptor binding#GO:0005102;hormone receptor binding#GO:0051427;cytokine receptor binding#GO:0005126;binding#GO:0005488;non-membrane spanning protein tyrosine kinase activity#GO:0004715;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein binding#GO:0005515;protein kinase activity#GO:0004672;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096 developmental process#GO:0032502;cell surface receptor signaling pathway via JAK-STAT#GO:0007259;innate immune response#GO:0045087;cellular developmental process#GO:0048869;response to external stimulus#GO:0009605;defense response#GO:0006952;immune response#GO:0006955;cellular response to nitrogen compound#GO:1901699;biological regulation#GO:0065007;response to other organism#GO:0051707;response to peptide hormone#GO:0043434;cytokine-mediated signaling pathway#GO:0019221;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;response to nitrogen compound#GO:1901698;intracellular signal transduction#GO:0035556;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;response to external biotic stimulus#GO:0043207;cellular response to peptide hormone stimulus#GO:0071375;cell surface receptor signaling pathway#GO:0007166;response to biotic stimulus#GO:0009607;response to hormone#GO:0009725;response to stress#GO:0006950;defense response to symbiont#GO:0140546;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987;response to type II interferon#GO:0034341;response to chemical#GO:0042221;response to cytokine#GO:0034097;defense response to other organism#GO:0098542;cell surface receptor signaling pathway via STAT#GO:0097696;cellular response to chemical stimulus#GO:0070887;immune system process#GO:0002376;type I interferon-mediated signaling pathway#GO:0060337;response to oxygen-containing compound#GO:1901700;response to peptide#GO:1901652;response to endogenous stimulus#GO:0009719;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;cell differentiation#GO:0030154;cellular response to hormone stimulus#GO:0032870;biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 non-receptor tyrosine protein kinase#PC00168 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>JAK#P00846 HUMAN|HGNC=17117|UniProtKB=Q9NQQ7 Q9NQQ7 SLC35H1 PTHR11132:SF238 SOLUTE CARRIER FAMILY 35 SOLUTE CARRIER FAMILY 35 MEMBER H1 active transmembrane transporter activity#GO:0022804;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;secondary active transmembrane transporter activity#GO:0015291;antiporter activity#GO:0015297 nucleotide-sugar transmembrane transport#GO:0015780;cellular process#GO:0009987;carbohydrate derivative transport#GO:1901264;nitrogen compound transport#GO:0071705;organophosphate ester transport#GO:0015748;nucleobase-containing compound transport#GO:0015931;transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;cis-Golgi network#GO:0005801;intracellular organelle#GO:0043229;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794 secondary carrier transporter#PC00258;transporter#PC00227 HUMAN|HGNC=17922|UniProtKB=Q9BWE0 Q9BWE0 REPIN1 PTHR24406:SF11 TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED DNA-BINDING PROTEIN REPIN1 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=25602|UniProtKB=Q86YJ6 Q86YJ6 THNSL2 PTHR42690:SF3 THREONINE SYNTHASE FAMILY MEMBER THREONINE SYNTHASE-LIKE 2 catalytic activity#GO:0003824;carbon-oxygen lyase activity#GO:0016835;heterocyclic compound binding#GO:1901363;small molecule binding#GO:0036094;anion binding#GO:0043168;binding#GO:0005488;ion binding#GO:0043167;lyase activity#GO:0016829 proteinogenic amino acid biosynthetic process#GO:0170038;small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;amino acid biosynthetic process#GO:0008652;biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;small molecule metabolic process#GO:0044281;proteinogenic amino acid metabolic process#GO:0170039;cellular process#GO:0009987;aspartate family amino acid biosynthetic process#GO:0009067;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752 Threonine biosynthesis#P02781>Threonine synthase#P03190 HUMAN|HGNC=10530|UniProtKB=O00422 O00422 SAP18 PTHR13082:SF1 SAP18 HISTONE DEACETYLASE COMPLEX SUBUNIT SAP18 transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=9336|UniProtKB=P78395 P78395 PRAME PTHR14224:SF110 SIMILAR TO PREFERENTIALLY EXPRESSED ANTIGEN IN MELANOMA-LIKE 3 MELANOMA ANTIGEN PREFERENTIALLY EXPRESSED IN TUMORS enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 Cul2-RING ubiquitin ligase complex#GO:0031462;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;ubiquitin ligase complex#GO:0000151;cytoplasm#GO:0005737;cullin-RING ubiquitin ligase complex#GO:0031461;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 HUMAN|HGNC=26951|UniProtKB=Q86YL5 Q86YL5 TDRP PTHR35663:SF1 TESTIS DEVELOPMENT-RELATED PROTEIN-RELATED TESTIS DEVELOPMENT-RELATED PROTEIN multicellular organismal reproductive process#GO:0048609;spermatogenesis#GO:0007283;sexual reproduction#GO:0019953;developmental process#GO:0032502;male gamete generation#GO:0048232;gamete generation#GO:0007276;reproductive process#GO:0022414;developmental process involved in reproduction#GO:0003006 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;cytosol#GO:0005829 HUMAN|HGNC=14219|UniProtKB=Q96PK6 Q96PK6 RBM14 PTHR23147:SF53 SERINE/ARGININE RICH SPLICING FACTOR RNA-BINDING PROTEIN 14 nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear speck#GO:0016607;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232;nuclear body#GO:0016604;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membraneless organelle#GO:0043228 RNA processing factor#PC00147;RNA metabolism protein#PC00031;RNA splicing factor#PC00148 HUMAN|HGNC=21214|UniProtKB=Q96IZ2 Q96IZ2 ADTRP PTHR10989:SF17 ANDROGEN-INDUCED PROTEIN 1-RELATED ANDROGEN-DEPENDENT TFPI-REGULATING PROTEIN carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;hydrolase activity#GO:0016787 cellular process#GO:0009987;lipid catabolic process#GO:0016042;carboxylic acid catabolic process#GO:0046395;long-chain fatty acid metabolic process#GO:0001676;monocarboxylic acid catabolic process#GO:0072329;lipid metabolic process#GO:0006629;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;monocarboxylic acid metabolic process#GO:0032787;small molecule catabolic process#GO:0044282;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;oxoacid metabolic process#GO:0043436;fatty acid catabolic process#GO:0009062 plasma membrane raft#GO:0044853;membrane microdomain#GO:0098857;plasma membrane#GO:0005886;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;caveola#GO:0005901;membrane raft#GO:0045121;membrane#GO:0016020 HUMAN|Ensembl=ENSG00000293569.1|UniProtKB=A0AB56JHH5 A0AB56JHH5 PTHR10424:SF81 VIRAL ENVELOPE PROTEIN ENVELOPE GLYCOPROTEIN viral or transposable element protein#PC00237 HUMAN|HGNC=10006|UniProtKB=Q02094 Q02094 RHAG PTHR11730:SF32 AMMONIUM TRANSPORTER AMMONIUM TRANSPORTER RH TYPE A channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;inorganic ion homeostasis#GO:0098771;chemical homeostasis#GO:0048878;transport#GO:0006810;homeostatic process#GO:0042592;cellular process#GO:0009987;nitrogen compound transport#GO:0071705 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 primary active transporter#PC00068;transporter#PC00227 HUMAN|HGNC=6945|UniProtKB=P25205 P25205 MCM3 PTHR11630:SF106 DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER DNA REPLICATION LICENSING FACTOR MCM3 DNA binding#GO:0003677;ATP-dependent activity, acting on DNA#GO:0008094;single-stranded DNA binding#GO:0003697;ATP-dependent activity#GO:0140657;nucleic acid binding#GO:0003676;binding#GO:0005488;isomerase activity#GO:0016853;DNA helicase activity#GO:0003678;catalytic activity, acting on DNA#GO:0140097;helicase activity#GO:0004386;macromolecular conformation isomerase activity#GO:0120543;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545 DNA replication initiation#GO:0006270;DNA recombination#GO:0006310;DNA damage response#GO:0006974;DNA metabolic process#GO:0006259;mitotic DNA replication#GO:1902969;nuclear DNA replication#GO:0033260;metabolic process#GO:0008152;cell cycle DNA replication#GO:0044786;DNA repair#GO:0006281;double-strand break repair#GO:0006302;mitotic cell cycle process#GO:1903047;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;response to stress#GO:0006950;double-strand break repair via break-induced replication#GO:0000727;nucleobase-containing compound metabolic process#GO:0006139;cellular response to stress#GO:0033554;recombinational repair#GO:0000725;DNA-templated DNA replication#GO:0006261;double-strand break repair via homologous recombination#GO:0000724;DNA replication#GO:0006260;cell cycle process#GO:0022402;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cell cycle#GO:0007049;DNA strand elongation involved in DNA replication#GO:0006271;mitotic cell cycle#GO:0000278;response to stimulus#GO:0050896 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;MCM complex#GO:0042555;intracellular organelle#GO:0043229 DNA metabolism protein#PC00009 HUMAN|HGNC=757|UniProtKB=Q12797 Q12797 ASPH PTHR12366:SF33 ASPARTYL/ASPARAGINYL BETA-HYDROXYLASE ASPARTYL_ASPARAGINYL BETA-HYDROXYLASE dioxygenase activity#GO:0051213;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824 regulation of cytosolic calcium ion concentration#GO:0051480;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion homeostasis#GO:0050801;homeostatic process#GO:0042592;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;inorganic ion homeostasis#GO:0098771;chemical homeostasis#GO:0048878;calcium ion homeostasis#GO:0055074;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;cellular homeostasis#GO:0019725 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 protein modifying enzyme#PC00260 HUMAN|HGNC=1313|UniProtKB=Q9NWS6 Q9NWS6 FAM118A PTHR28623:SF2 PROTEIN FAM118B PROTEIN FAM118A hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;catalytic activity#GO:0003824 defense response to symbiont#GO:0140546;immune response#GO:0006955;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;response to other organism#GO:0051707;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;defense response to other organism#GO:0098542;response to stimulus#GO:0050896;immune system process#GO:0002376;defense response#GO:0006952;response to external stimulus#GO:0009605;innate immune response#GO:0045087 HUMAN|HGNC=671|UniProtKB=P61587 P61587 RND3 PTHR24072:SF24 RHO FAMILY GTPASE RHO-RELATED GTP-BINDING PROTEIN RHOE catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleotide binding#GO:0000166;anion binding#GO:0043168;small molecule binding#GO:0036094;GTPase activity#GO:0003924;ion binding#GO:0043167;hydrolase activity#GO:0016787;ribonucleotide binding#GO:0032553;hydrolase activity, acting on acid anhydrides#GO:0016817;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;enzyme binding#GO:0019899;guanyl nucleotide binding#GO:0019001;protein kinase binding#GO:0019901;kinase binding#GO:0019900;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;nucleoside phosphate binding#GO:1901265;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;protein binding#GO:0005515 regulation of actin filament-based process#GO:0032970;cellular component organization or biogenesis#GO:0071840;actin filament organization#GO:0007015;organelle organization#GO:0006996;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of actin cytoskeleton organization#GO:0032956;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;actin filament-based process#GO:0030029;cell communication#GO:0007154;supramolecular fiber organization#GO:0097435;cellular component organization#GO:0016043;cellular response to stimulus#GO:0051716;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;actin cytoskeleton organization#GO:0030036;regulation of cytoskeleton organization#GO:0051493;response to stimulus#GO:0050896;regulation of cellular component organization#GO:0051128;signaling#GO:0023052 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886;membrane#GO:0016020;cytosol#GO:0005829;cell periphery#GO:0071944 G-protein#PC00020;small GTPase#PC00208 Integrin signalling pathway#P00034>Rho#P00948 HUMAN|HGNC=4940|UniProtKB=P04440 P04440 HLA-DPB1 PTHR19944:SF46 MHC CLASS II-RELATED HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DP BETA 1 CHAIN protein-containing complex binding#GO:0044877;binding#GO:0005488;peptide binding#GO:0042277;antigen binding#GO:0003823 regulation of leukocyte cell-cell adhesion#GO:1903037;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;positive regulation of response to stimulus#GO:0048584;regulation of cell adhesion#GO:0030155;biological regulation#GO:0065007;positive regulation of leukocyte cell-cell adhesion#GO:1903039;positive regulation of cell activation#GO:0050867;positive regulation of cellular process#GO:0048522;positive regulation of lymphocyte activation#GO:0051251;antigen processing and presentation#GO:0019882;regulation of immune response#GO:0050776;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of cell-cell adhesion#GO:0022407;positive regulation of cell adhesion#GO:0045785;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;positive regulation of leukocyte activation#GO:0002696;cellular component assembly#GO:0022607;positive regulation of T cell activation#GO:0050870;regulation of T cell activation#GO:0050863;regulation of multicellular organismal process#GO:0051239;positive regulation of cell-cell adhesion#GO:0022409;cellular component biogenesis#GO:0044085;positive regulation of immune system process#GO:0002684;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;immune system process#GO:0002376;regulation of lymphocyte activation#GO:0051249;regulation of leukocyte activation#GO:0002694;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;regulation of biological process#GO:0050789;regulation of cell activation#GO:0050865;positive regulation of multicellular organismal process#GO:0051240 intracellular organelle#GO:0043229;endosome membrane#GO:0010008;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;vesicle#GO:0031982;lysosome#GO:0005764;plasma membrane protein complex#GO:0098797;lytic vacuole membrane#GO:0098852;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;late endosome membrane#GO:0031902;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;lytic vacuole#GO:0000323;vacuolar membrane#GO:0005774;lysosomal membrane#GO:0005765;cell periphery#GO:0071944;vesicle membrane#GO:0012506;membrane#GO:0016020;vacuole#GO:0005773;plasma membrane#GO:0005886;cytoplasm#GO:0005737;late endosome#GO:0005770;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659 major histocompatibility complex protein#PC00149 HUMAN|HGNC=26759|UniProtKB=Q8N9A8 Q8N9A8 CNEP1R1 PTHR20996:SF2 NUCLEAR ENVELOPE PHOSPHATASE-REGULATORY SUBUNIT 1 NUCLEAR ENVELOPE PHOSPHATASE-REGULATORY SUBUNIT 1 membrane protein complex#GO:0098796;membrane#GO:0016020;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasm#GO:0005737;protein serine/threonine phosphatase complex#GO:0008287;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622 phosphatase modulator#PC00184 HUMAN|HGNC=6068|UniProtKB=P55103 P55103 INHBC PTHR11848:SF130 TGF-BETA FAMILY INHIBIN BETA C CHAIN signaling receptor regulator activity#GO:0030545;cytokine activity#GO:0005125;receptor ligand activity#GO:0048018;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;cell surface receptor signaling pathway#GO:0007166;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 growth factor#PC00112 TGF-beta signaling pathway#P00052>TGFbeta#P01286 HUMAN|HGNC=9527|UniProtKB=O75475 O75475 PSIP1 PTHR12550:SF42 HEPATOMA-DERIVED GROWTH FACTOR-RELATED PC4 AND SFRS1-INTERACTING PROTEIN cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;chromatin remodeling#GO:0006338;chromatin organization#GO:0006325 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HUMAN|HGNC=17343|UniProtKB=P31941 P31941 APOBEC3A PTHR13857:SF49 MRNA EDITING ENZYME DNA DC-DU-EDITING ENZYME APOBEC-3A nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;deaminase activity#GO:0019239 regulation of nucleobase-containing compound metabolic process#GO:0019219;response to other organism#GO:0051707;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;defense response#GO:0006952;response to external stimulus#GO:0009605;negative regulation of cellular process#GO:0048523;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;response to external biotic stimulus#GO:0043207;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cytidine to uridine editing#GO:0016554;macromolecule modification#GO:0043412;response to virus#GO:0009615;regulation of RNA metabolic process#GO:0051252;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;response to stimulus#GO:0050896;negative regulation of metabolic process#GO:0009892;biological process involved in interspecies interaction between organisms#GO:0044419;negative regulation of biological process#GO:0048519;defense response to virus#GO:0051607;regulation of biological process#GO:0050789;RNA metabolic process#GO:0016070;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;base conversion or substitution editing#GO:0016553;RNA modification#GO:0009451 cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;nucleus#GO:0005634;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;P-body#GO:0000932;intracellular organelle#GO:0043229 RNA processing factor#PC00147 HUMAN|HGNC=17032|UniProtKB=Q9Y279 Q9Y279 VSIG4 PTHR15466:SF2 V-SET AND IMMUNOGLOBULIN DOMAIN CONTAINING 4 V-SET AND IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN 4 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=18144|UniProtKB=Q8IZU8 Q8IZU8 DSEL PTHR15532:SF2 FAMILY NOT NAMED DERMATAN-SULFATE EPIMERASE-LIKE PROTEIN catalytic activity#GO:0003824;racemase and epimerase activity, acting on carbohydrates and derivatives#GO:0016857;racemase and epimerase activity#GO:0016854;isomerase activity#GO:0016853 primary metabolic process#GO:0044238;cellular process#GO:0009987;chondroitin sulfate proteoglycan metabolic process#GO:0050654;carbohydrate derivative metabolic process#GO:1901135;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;proteoglycan metabolic process#GO:0006029 HUMAN|HGNC=26787|UniProtKB=Q8N8X9 Q8N8X9 MAB21L3 PTHR10656:SF30 CELL FATE DETERMINING PROTEIN MAB21-RELATED PROTEIN MAB-21-LIKE 3 transferase#PC00220;nucleotidyltransferase#PC00174 HUMAN|HGNC=33854|UniProtKB=Q569K6 Q569K6 CCDC157 PTHR43696:SF9 COILED-COIL DOMAIN-CONTAINING PROTEIN 157 COILED-COIL DOMAIN-CONTAINING PROTEIN 157 HUMAN|HGNC=30960|UniProtKB=Q7Z7L7 Q7Z7L7 ZER1 PTHR12904:SF23 FAMILY NOT NAMED PROTEIN ZER-1 HOMOLOG ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461;Cul2-RING ubiquitin ligase complex#GO:0031462;catalytic complex#GO:1902494;transferase complex#GO:1990234 HUMAN|HGNC=1938|UniProtKB=Q9Y259 Q9Y259 CHKB PTHR22603:SF35 CHOLINE/ETHANOALAMINE KINASE CHOLINE_ETHANOLAMINE KINASE phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824 lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474;metabolic process#GO:0008152;organophosphate biosynthetic process#GO:0090407;glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;organophosphate metabolic process#GO:0019637;phospholipid metabolic process#GO:0006644;biosynthetic process#GO:0009058;phospholipid biosynthetic process#GO:0008654;lipid biosynthetic process#GO:0008610;glycerolipid metabolic process#GO:0046486;glycerophospholipid metabolic process#GO:0006650 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 kinase#PC00137 HUMAN|HGNC=15471|UniProtKB=Q9H2A2 Q9H2A2 ALDH8A1 PTHR43720:SF4 2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE 2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE oxidoreductase activity, acting on the aldehyde or oxo group of donors#GO:0016903;catalytic activity#GO:0003824;aldehyde dehydrogenase (NAD+) activity#GO:0004029;oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor#GO:0016620;oxidoreductase activity#GO:0016491 isoprenoid metabolic process#GO:0006720;regulation of biological quality#GO:0065008;oxoacid metabolic process#GO:0043436;terpenoid metabolic process#GO:0006721;small molecule metabolic process#GO:0044281;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;regulation of hormone levels#GO:0010817;retinoid metabolic process#GO:0001523;diterpenoid metabolic process#GO:0016101;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;hormone metabolic process#GO:0042445;biological regulation#GO:0065007;cellular process#GO:0009987 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 5-Hydroxytryptamine degredation#P04372>Aldehyde Dehydrogenase#P04402 HUMAN|HGNC=19371|UniProtKB=Q8NE31 Q8NE31 FAM13C PTHR15904:SF19 FAM13 PROTEIN FAM13C HUMAN|HGNC=23136|UniProtKB=Q9BWG6 Q9BWG6 SCNM1 PTHR32297:SF1 SODIUM CHANNEL MODIFIER 1 SODIUM CHANNEL MODIFIER 1 RNA processing#GO:0006396;RNA biosynthetic process#GO:0032774;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=19030|UniProtKB=Q8IZF2 Q8IZF2 ADGRF5 PTHR45813:SF13 IG-LIKE DOMAIN-CONTAINING PROTEIN ADHESION G PROTEIN-COUPLED RECEPTOR F5 transmembrane signaling receptor activity#GO:0004888;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 chemical homeostasis#GO:0048878;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;generation of precursor metabolites and energy#GO:0006091;metabolic process#GO:0008152;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;multicellular organismal-level homeostasis#GO:0048871;glucose homeostasis#GO:0042593;energy derivation by oxidation of organic compounds#GO:0015980;cellular process#GO:0009987;signal transduction#GO:0007165;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;energy reserve metabolic process#GO:0006112;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;carbohydrate homeostasis#GO:0033500;regulation of biological process#GO:0050789;signaling#GO:0023052;homeostatic process#GO:0042592;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021 HUMAN|HGNC=25896|UniProtKB=Q96D31 Q96D31 ORAI1 PTHR31501:SF3 CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL PROTEIN 1 CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL PROTEIN 1 passive transmembrane transporter activity#GO:0022803;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261;metal ion transmembrane transporter activity#GO:0046873;calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267 transport#GO:0006810;calcium ion transport#GO:0006816;monoatomic ion transport#GO:0006811;metal ion transport#GO:0030001;establishment of localization#GO:0051234;localization#GO:0051179;monoatomic cation transport#GO:0006812 cellular anatomical structure#GO:0110165;membrane#GO:0016020 ion channel#PC00133 HUMAN|HGNC=27653|UniProtKB=Q6PIV7 Q6PIV7 SLC25A34 PTHR45928:SF3 RE38146P SOLUTE CARRIER FAMILY 25 MEMBER 34 HUMAN|HGNC=6436|UniProtKB=P08727 P08727 KRT19 PTHR23239:SF14 INTERMEDIATE FILAMENT KERATIN, TYPE I CYTOSKELETAL 19 structural molecule activity#GO:0005198 intermediate filament cytoskeleton organization#GO:0045104;cell differentiation#GO:0030154;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;supramolecular fiber organization#GO:0097435;anatomical structure development#GO:0048856;tissue morphogenesis#GO:0048729;intermediate filament organization#GO:0045109;animal gross anatomical part developmental process#GO:0160108;intermediate filament-based process#GO:0045103;cytoskeleton organization#GO:0007010;tissue development#GO:0009888;epithelial cell differentiation#GO:0030855;epithelium development#GO:0060429;cellular process#GO:0009987;organelle organization#GO:0006996;morphogenesis of an epithelium#GO:0002009;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;developmental process#GO:0032502 intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;organelle#GO:0043226;supramolecular complex#GO:0099080;intracellular anatomical structure#GO:0005622;intermediate filament#GO:0005882;supramolecular fiber#GO:0099512;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 intermediate filament#PC00129 HUMAN|HGNC=29289|UniProtKB=Q9P260 Q9P260 RELCH PTHR32059:SF2 RAB11-BINDING PROTEIN RELCH RAB11-BINDING PROTEIN RELCH cholesterol transport#GO:0030301;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;lipid transport#GO:0006869;intracellular sterol transport#GO:0032366;intracellular transport#GO:0046907;lipid localization#GO:0010876;transport#GO:0006810;cellular localization#GO:0051641;sterol transport#GO:0015918;establishment of localization#GO:0051234;localization#GO:0051179;organic hydroxy compound transport#GO:0015850 Golgi apparatus#GO:0005794;recycling endosome#GO:0055037;endomembrane system#GO:0012505;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;Golgi apparatus subcompartment#GO:0098791;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endosome#GO:0005768;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982 HUMAN|HGNC=8748|UniProtKB=Q16549 Q16549 PCSK7 PTHR42884:SF28 PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED PROPROTEIN CONVERTASE SUBTILISIN_KEXIN TYPE 7 serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233 primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein processing#GO:0016485;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;proteolysis#GO:0006508;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;endomembrane system#GO:0012505;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 serine protease#PC00203 Alzheimer disease-presenilin pathway#P00004>Furin#P00157;Alzheimer disease-amyloid secretase pathway#P00003>Furin#P00105 HUMAN|HGNC=20776|UniProtKB=Q9BUF5 Q9BUF5 TUBB6 PTHR11588:SF88 TUBULIN TUBULIN BETA-6 CHAIN anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167;nucleotide binding#GO:0000166;structural molecule activity#GO:0005198;guanyl nucleotide binding#GO:0019001;structural constituent of cytoskeleton#GO:0005200;binding#GO:0005488;nucleoside phosphate binding#GO:1901265;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;ribonucleotide binding#GO:0032553;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;carbohydrate derivative binding#GO:0097367;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363 cellular component organization#GO:0016043;cell cycle#GO:0007049;organelle organization#GO:0006996;cellular process#GO:0009987;mitotic cell cycle#GO:0000278;cytoskeleton organization#GO:0007010;microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017 membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;organelle#GO:0043226;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630 tubulin#PC00228;cytoskeletal protein#PC00085 Huntington disease#P00029>beta-Tubulin#P00790;Cytoskeletal regulation by Rho GTPase#P00016>tubulin#P00526;Huntington disease#P00029>Microtubule#P00780 HUMAN|HGNC=34443|UniProtKB=A8MXK1 A8MXK1 VSTM5 PTHR12080:SF93 SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE V-SET AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 5 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;regulation of developmental process#GO:0050793;regulation of cell junction assembly#GO:1901888;regulation of synapse structure or activity#GO:0050803;regulation of nervous system development#GO:0051960;cell communication#GO:0007154;filopodium assembly#GO:0046847;positive regulation of cellular process#GO:0048522;immune response#GO:0006955;regulation of synapse assembly#GO:0051963;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;plasma membrane bounded cell projection assembly#GO:0120031;positive regulation of developmental process#GO:0051094;positive regulation of synapse assembly#GO:0051965;cellular component organization#GO:0016043;positive regulation of multicellular organismal process#GO:0051240;regulation of multicellular organismal development#GO:2000026;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;positive regulation of nervous system development#GO:0051962;regulation of cellular component organization#GO:0051128;cell projection organization#GO:0030030;regulation of cellular component biogenesis#GO:0044087;signaling#GO:0023052;immune system process#GO:0002376;regulation of synapse organization#GO:0050807;positive regulation of cellular component organization#GO:0051130;regulation of biological quality#GO:0065008;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cell projection assembly#GO:0030031;positive regulation of cellular component biogenesis#GO:0044089;cellular component assembly#GO:0022607;regulation of multicellular organismal process#GO:0051239;cellular component organization or biogenesis#GO:0071840 axon#GO:0030424;dendritic tree#GO:0097447;dendrite#GO:0030425;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;somatodendritic compartment#GO:0036477;cellular anatomical structure#GO:0110165;neuron projection#GO:0043005 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=11947|UniProtKB=P19429 P19429 TNNI3 PTHR13738:SF2 TROPONIN I TROPONIN I, CARDIAC MUSCLE protein binding#GO:0005515;binding#GO:0005488;cytoskeletal protein binding#GO:0008092 muscle system process#GO:0003012;heart process#GO:0003015;blood circulation#GO:0008015;multicellular organismal process#GO:0032501;striated muscle contraction#GO:0006941;skeletal muscle contraction#GO:0003009;circulatory system process#GO:0003013;neuromuscular process#GO:0050905;muscle contraction#GO:0006936;cardiac muscle contraction#GO:0060048;nervous system process#GO:0050877;heart contraction#GO:0060047;system process#GO:0003008 cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;sarcomere#GO:0030017;contractile muscle fiber#GO:0043292;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;myofibril#GO:0030016;actin cytoskeleton#GO:0015629;cellular anatomical structure#GO:0110165;organelle#GO:0043226 non-motor actin binding protein#PC00165 HUMAN|HGNC=5558|UniProtKB=P01742 P01742 IGHV1-69 PTHR23266:SF262 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 1-69-RELATED binding#GO:0005488;antigen binding#GO:0003823 immune response#GO:0006955;response to stimulus#GO:0050896;adaptive immune response#GO:0002250;immune system process#GO:0002376;immune effector process#GO:0002252;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=14525|UniProtKB=Q9UHD1 Q9UHD1 CHORDC1 PTHR12621:SF9 CYSTEINE AND HISTIDINE-RICH DOMAIN CHORD -CONTAINING PROTEIN CYSTEINE AND HISTIDINE-RICH DOMAIN-CONTAINING PROTEIN 1 cation binding#GO:0043169;metal ion binding#GO:0046872;transition metal ion binding#GO:0046914;small molecule binding#GO:0036094;binding#GO:0005488;zinc ion binding#GO:0008270;ion binding#GO:0043167 microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;centrosome duplication#GO:0051298;microtubule-based process#GO:0007017;microtubule organizing center organization#GO:0031023;cellular component organization#GO:0016043;cell cycle#GO:0007049;organelle organization#GO:0006996;cell cycle process#GO:0022402;cellular process#GO:0009987;centrosome cycle#GO:0007098;cytoskeleton organization#GO:0007010 scaffold/adaptor protein#PC00226 HUMAN|HGNC=16812|UniProtKB=Q8NI60 Q8NI60 COQ8A PTHR43851:SF1 FAMILY NOT NAMED ATYPICAL KINASE COQ8A, MITOCHONDRIAL biosynthetic process#GO:0009058;small molecule metabolic process#GO:0044281;ubiquinone biosynthetic process#GO:0006744;cellular process#GO:0009987;ketone biosynthetic process#GO:0042181;ketone metabolic process#GO:0042180;small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152 HUMAN|HGNC=16879|UniProtKB=O95072 O95072 REC8 PTHR12585:SF27 SCC1 / RAD21 FAMILY MEMBER MEIOTIC RECOMBINATION PROTEIN REC8 HOMOLOG chromatin binding#GO:0003682;binding#GO:0005488 cellular process#GO:0009987;response to stress#GO:0006950;replication-born double-strand break repair via sister chromatid exchange#GO:1990414;organelle organization#GO:0006996;nucleobase-containing compound metabolic process#GO:0006139;DNA damage response#GO:0006974;DNA recombination#GO:0006310;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;double-strand break repair#GO:0006302;chromosome organization#GO:0051276;meiotic sister chromatid cohesion#GO:0051177;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;cellular response to stimulus#GO:0051716;cell cycle process#GO:0022402;double-strand break repair via homologous recombination#GO:0000724;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;cell cycle#GO:0007049;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;recombinational repair#GO:0000725;sister chromatid cohesion#GO:0007062 intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cohesin complex#GO:0008278;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;chromosome#GO:0005694;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229 HUMAN|HGNC=19117|UniProtKB=Q6ZNL6 Q6ZNL6 FGD5 PTHR12673:SF13 FACIOGENITAL DYSPLASIA PROTEIN FYVE, RHOGEF AND PH DOMAIN-CONTAINING PROTEIN 5 guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 G-protein modulator#PC00022;guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=10607|UniProtKB=P09683 P09683 SCT PTHR17378:SF1 SECRETIN SECRETIN signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515 biological regulation#GO:0065007;multicellular organismal process#GO:0032501;brain development#GO:0007420;positive regulation of cellular process#GO:0048522;developmental process#GO:0032502;regulation of system process#GO:0044057;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;negative regulation of transport#GO:0051051;negative regulation of multicellular organismal process#GO:0051241;system development#GO:0048731;anatomical structure development#GO:0048856;regulation of secretion#GO:0051046;positive regulation of hormone secretion#GO:0046887;head development#GO:0060322;nervous system development#GO:0007399;regulation of multicellular organismal process#GO:0051239;positive regulation of transport#GO:0051050;positive regulation of biological process#GO:0048518;positive regulation of secretion by cell#GO:1903532;regulation of transport#GO:0051049;regulation of localization#GO:0032879;animal organ development#GO:0048513;multicellular organism development#GO:0007275;regulation of body fluid levels#GO:0050878;central nervous system development#GO:0007417;regulation of hormone levels#GO:0010817;positive regulation of multicellular organismal process#GO:0051240;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of biological quality#GO:0065008;regulation of secretion by cell#GO:1903530;positive regulation of signaling#GO:0023056;regulation of hormone secretion#GO:0046883;regulation of signaling#GO:0023051;positive regulation of secretion#GO:0051047;animal gross anatomical part developmental process#GO:0160108 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=23039|UniProtKB=O94874 O94874 UFL1 PTHR31057:SF0 E3 UFM1-PROTEIN LIGASE 1 E3 UFM1-PROTEIN LIGASE 1 ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 autophagy#GO:0006914;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stress#GO:0006950;reticulophagy#GO:0061709;macroautophagy#GO:0016236;response to stimulus#GO:0050896;catabolic process#GO:0009056;cellular response to stress#GO:0033554;metabolic process#GO:0008152;response to endoplasmic reticulum stress#GO:0034976;process utilizing autophagic mechanism#GO:0061919 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=24011|UniProtKB=Q9NYB9 Q9NYB9 ABI2 PTHR10460:SF26 ABL INTERACTOR FAMILY MEMBER ABL INTERACTOR 2 signaling adaptor activity#GO:0035591;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 nervous system development#GO:0007399;multicellular organismal process#GO:0032501;cell migration#GO:0016477;cellular process#GO:0009987;cell projection morphogenesis#GO:0048858;neurogenesis#GO:0022008;cellular component organization or biogenesis#GO:0071840;neuron migration#GO:0001764;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;developmental process#GO:0032502;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell motility#GO:0048870;cell morphogenesis#GO:0000902;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;system development#GO:0048731;anatomical structure development#GO:0048856;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108 intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;organelle#GO:0043226;lamellipodium#GO:0030027;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;actin-based cell projection#GO:0098858;actin cytoskeleton#GO:0015629;cell leading edge#GO:0031252;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 scaffold/adaptor protein#PC00226 HUMAN|HGNC=19977|UniProtKB=Q96NR8 Q96NR8 RDH12 PTHR24320:SF227 RETINOL DEHYDROGENASE RETINOL DEHYDROGENASE 12 oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;alcohol dehydrogenase (NADP+) activity#GO:0008106;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;catalytic activity#GO:0003824 primary metabolic process#GO:0044238;regulation of hormone levels#GO:0010817;small molecule metabolic process#GO:0044281;retinol metabolic process#GO:0042572;olefinic compound metabolic process#GO:0120254;terpenoid metabolic process#GO:0006721;isoprenoid metabolic process#GO:0006720;regulation of biological quality#GO:0065008;cellular process#GO:0009987;aldehyde metabolic process#GO:0006081;hormone metabolic process#GO:0042445;biological regulation#GO:0065007;metabolic process#GO:0008152;alcohol metabolic process#GO:0006066;lipid metabolic process#GO:0006629;retinoid metabolic process#GO:0001523;diterpenoid metabolic process#GO:0016101 endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;membrane#GO:0016020;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 oxidoreductase#PC00176;dehydrogenase#PC00092 HUMAN|HGNC=13422|UniProtKB=Q9NZH4 Q9NZH4 PTTG3P PTHR10418:SF3 SECURIN-3 PITUITARY TUMOR-TRANSFORMING GENE 3 PROTEIN-RELATED enzyme inhibitor activity#GO:0004857;molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866;peptidase regulator activity#GO:0061134;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;molecular function inhibitor activity#GO:0140678;cysteine-type endopeptidase inhibitor activity#GO:0004869;enzyme regulator activity#GO:0030234 meiotic cell cycle#GO:0051321;chromosome segregation#GO:0007059;homologous chromosome segregation#GO:0045143;cellular component organization or biogenesis#GO:0071840;meiotic nuclear division#GO:0140013;meiotic chromosome segregation#GO:0045132;organelle organization#GO:0006996;cellular process#GO:0009987;meiosis I cell cycle process#GO:0061982;nuclear division#GO:0000280;sexual reproduction#GO:0019953;organelle fission#GO:0048285;cell cycle#GO:0007049;nuclear chromosome segregation#GO:0098813;meiosis I#GO:0007127;meiotic cell cycle process#GO:1903046;cellular component organization#GO:0016043;cell cycle process#GO:0022402;reproductive process#GO:0022414 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=28045|UniProtKB=Q9NTI7 Q9NTI7 INKA2 PTHR28615:SF2 PAK4-INHIBITOR INKA1-RELATED PAK4-INHIBITOR INKA2 kinase binding#GO:0019900;binding#GO:0005488;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;enzyme regulator activity#GO:0030234;protein binding#GO:0005515;molecular function inhibitor activity#GO:0140678;enzyme inhibitor activity#GO:0004857;kinase inhibitor activity#GO:0019210;protein kinase regulator activity#GO:0019887;molecular function regulator activity#GO:0098772;protein kinase inhibitor activity#GO:0004860;kinase regulator activity#GO:0019207 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=20376|UniProtKB=Q8NBK3 Q8NBK3 SUMF1 PTHR23150:SF37 SULFATASE MODIFYING FACTOR 1, 2 FORMYLGLYCINE-GENERATING ENZYME catalytic activity#GO:0003824;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;oxidoreductase activity#GO:0016491 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=5601|UniProtKB=A0A0C4DH36 A0A0C4DH36 IGHV3-38 PTHR23266:SF384 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 3-53-RELATED antigen binding#GO:0003823;binding#GO:0005488 immune effector process#GO:0002252;immune system process#GO:0002376;immunoglobulin mediated immune response#GO:0016064;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449;immune response#GO:0006955;adaptive immune response#GO:0002250;response to stimulus#GO:0050896 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=7976|UniProtKB=P24468 P24468 NR2F2 PTHR24083:SF45 NUCLEAR HORMONE RECEPTOR COUP TRANSCRIPTION FACTOR 2 sequence-specific double-stranded DNA binding#GO:1990837;molecular transducer activity#GO:0060089;cis-regulatory region sequence-specific DNA binding#GO:0000987;nuclear receptor activity#GO:0004879;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;ion binding#GO:0043167;small molecule binding#GO:0036094;nucleic acid binding#GO:0003676;anion binding#GO:0043168;transcription cis-regulatory region binding#GO:0000976;organic acid binding#GO:0043177;sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023;transcription regulatory region nucleic acid binding#GO:0001067;lipid binding#GO:0008289;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;carboxylic acid binding#GO:0031406;transcription regulator activity#GO:0140110 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;negative regulation of metabolic process#GO:0009892;animal gross anatomical part developmental process#GO:0160108;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;nervous system development#GO:0007399;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;multicellular organism development#GO:0007275 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 C4 zinc finger nuclear receptor#PC00169;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=896|UniProtKB=P47901 P47901 AVPR1B PTHR24241:SF18 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR VASOPRESSIN V1B RECEPTOR G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 response to hormone#GO:0009725;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;multicellular organismal process#GO:0032501;blood circulation#GO:0008015;response to chemical#GO:0042221;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;regulation of anatomical structure size#GO:0090066;regulation of system process#GO:0044057;system process#GO:0003008;response to endogenous stimulus#GO:0009719;cellular response to stimulus#GO:0051716;positive regulation of multicellular organismal process#GO:0051240;regulation of biological process#GO:0050789;cellular response to hormone stimulus#GO:0032870;regulation of cellular process#GO:0050794;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;signaling#GO:0023052;circulatory system process#GO:0003013;positive regulation of cytosolic calcium ion concentration#GO:0007204;G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887;cell communication#GO:0007154;regulation of biological quality#GO:0065008 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=10346|UniProtKB=Q969Q0 Q969Q0 RPL36AL PTHR10369:SF45 60S RIBOSOMAL PROTEIN L36A/L44 RIBOSOMAL PROTEIN EL42-LIKE structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;translation#GO:0006412;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;cytoplasmic translation#GO:0002181;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;ribosome#GO:0005840;cytosol#GO:0005829;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934 ribosomal protein#PC00202 HUMAN|HGNC=13078|UniProtKB=Q2VY69 Q2VY69 ZNF284 PTHR24388:SF109 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 221-RELATED RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=24842|UniProtKB=Q3B8N2 Q3B8N2 LGALS9B PTHR11346:SF80 GALECTIN GALECTIN-9B carbohydrate binding#GO:0030246;binding#GO:0005488;carbohydrate derivative binding#GO:0097367 regulation of leukocyte cell-cell adhesion#GO:1903037;negative regulation of cellular process#GO:0048523;regulation of biosynthetic process#GO:0009889;negative regulation of cell activation#GO:0050866;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;regulation of cytokine production#GO:0001817;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of cell population proliferation#GO:0008285;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of cell adhesion#GO:0007162;regulation of lymphocyte proliferation#GO:0050670;regulation of cell adhesion#GO:0030155;negative regulation of immune system process#GO:0002683;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;negative regulation of T cell activation#GO:0050868;regulation of cell population proliferation#GO:0042127;positive regulation of biosynthetic process#GO:0009891;negative regulation of multicellular organismal process#GO:0051241;regulation of macromolecule metabolic process#GO:0060255;regulation of T cell proliferation#GO:0042129;regulation of cell-cell adhesion#GO:0022407;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;negative regulation of leukocyte cell-cell adhesion#GO:1903038;regulation of leukocyte proliferation#GO:0070663;negative regulation of T cell proliferation#GO:0042130;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of mononuclear cell proliferation#GO:0032944;positive regulation of biological process#GO:0048518;negative regulation of cell-cell adhesion#GO:0022408;positive regulation of macromolecule metabolic process#GO:0010604;regulation of T cell activation#GO:0050863;negative regulation of lymphocyte activation#GO:0051250;negative regulation of leukocyte activation#GO:0002695;regulation of multicellular organismal process#GO:0051239;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of leukocyte activation#GO:0002694;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;regulation of cell activation#GO:0050865;negative regulation of metabolic process#GO:0009892;regulation of lymphocyte activation#GO:0051249 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;cytosol#GO:0005829 extracellular matrix protein#PC00102 HUMAN|HGNC=3337|UniProtKB=Q9UHX3 Q9UHX3 ADGRE2 PTHR12011:SF328 ADHESION G-PROTEIN COUPLED RECEPTOR ADHESION G PROTEIN-COUPLED RECEPTOR E2 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=2173|UniProtKB=Q9P232 Q9P232 CNTN3 PTHR12231:SF224 CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN CONTACTIN-3 immunoglobulin superfamily cell adhesion molecule#PC00125;cell adhesion molecule#PC00069 HUMAN|HGNC=29169|UniProtKB=Q9Y2L5 Q9Y2L5 TRAPPC8 PTHR12975:SF6 TRANSPORT PROTEIN TRAPP TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 8 organelle#GO:0043226;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;TRAPP complex#GO:0030008;membrane-bounded organelle#GO:0043227;vesicle tethering complex#GO:0099023;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 HUMAN|HGNC=3791|UniProtKB=P15328 P15328 FOLR1 PTHR10517:SF15 FOLATE RECEPTOR FOLATE RECEPTOR ALPHA signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;cargo receptor activity#GO:0038024 dicarboxylic acid transport#GO:0006835;vitamin transport#GO:0051180;nitrogen compound transport#GO:0071705;establishment of localization#GO:0051234;localization#GO:0051179;organic acid transport#GO:0015849;transport#GO:0006810;carboxylic acid transport#GO:0046942 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=9586|UniProtKB=Q9Y6C5 Q9Y6C5 PTCH2 PTHR46022:SF3 PROTEIN PATCHED PROTEIN PATCHED HOMOLOG 2 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;protein binding#GO:0005515;transmembrane signaling receptor activity#GO:0004888;G protein-coupled receptor binding#GO:0001664;signaling receptor binding#GO:0005102;binding#GO:0005488 regulation of cellular process#GO:0050794;negative regulation of response to stimulus#GO:0048585;negative regulation of signal transduction#GO:0009968;regulation of cell communication#GO:0010646;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of cell communication#GO:0010648;negative regulation of cellular process#GO:0048523;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=19956|UniProtKB=Q92537 Q92537 SUSD6 PTHR46839:SF2 SUSHI DOMAIN-CONTAINING PROTEIN 6 SUSHI DOMAIN-CONTAINING PROTEIN 6 HUMAN|HGNC=18117|UniProtKB=O75525 O75525 KHDRBS3 PTHR11208:SF29 RNA-BINDING PROTEIN RELATED KH DOMAIN-CONTAINING, RNA-BINDING, SIGNAL TRANSDUCTION-ASSOCIATED PROTEIN 3 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729 regulation of alternative mRNA splicing, via spliceosome#GO:0000381;regulation of RNA metabolic process#GO:0051252;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of mRNA metabolic process#GO:1903311;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of mRNA processing#GO:0050684;regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 RNA processing factor#PC00147;RNA splicing factor#PC00148 HUMAN|HGNC=7968|UniProtKB=O75469 O75469 NR1I2 PTHR24082:SF39 NUCLEAR HORMONE RECEPTOR NUCLEAR RECEPTOR SUBFAMILY 1 GROUP I MEMBER 2 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;molecular transducer activity#GO:0060089;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;nuclear receptor activity#GO:0004879;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023 negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of transcription by RNA polymerase II#GO:0045944;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;negative regulation of DNA-templated transcription#GO:0045892;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C4 zinc finger nuclear receptor#PC00169 Angiogenesis#P00005>PAR#P00192 HUMAN|HGNC=23676|UniProtKB=Q5T1J5 Q5T1J5 CHCHD2P9 PTHR13523:SF3 COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2/NUR77 COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 2-RELATED nucleic acid binding#GO:0003676;binding#GO:0005488;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677 positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;organelle organization#GO:0006996;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;mitochondrion organization#GO:0007005;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of gene expression#GO:0010468;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=14261|UniProtKB=Q9NS28 Q9NS28 RGS18 PTHR10845:SF155 REGULATOR OF G PROTEIN SIGNALING REGULATOR OF G PROTEIN SIGNALING 18 enzyme activator activity#GO:0008047;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 negative regulation of signaling#GO:0023057;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;regulation of G protein-coupled receptor signaling pathway#GO:0008277;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;negative regulation of G protein-coupled receptor signaling pathway#GO:0045744;regulation of biological process#GO:0050789;negative regulation of response to stimulus#GO:0048585;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;negative regulation of signal transduction#GO:0009968 cell periphery#GO:0071944;cytoplasmic side of membrane#GO:0098562;membrane#GO:0016020;cytoplasmic side of plasma membrane#GO:0009898;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552 GTPase-activating protein#PC00257 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>RGS#P00833;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>RGS#P00704;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>RGS#P00731 HUMAN|HGNC=29313|UniProtKB=Q9HCK1 Q9HCK1 ZDBF2 PTHR21639:SF5 DBF4-TYPE ZINC FINGER-CONTAINING PROTEIN 2 DBF4-TYPE ZINC FINGER-CONTAINING PROTEIN 2 chromatin remodeling#GO:0006338;cellular process involved in reproduction in multicellular organism#GO:0022412;cell development#GO:0048468;reproductive process#GO:0022414;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;gamete generation#GO:0007276;regulation of biological process#GO:0050789;germ cell development#GO:0007281;developmental process involved in reproduction#GO:0003006;cellular component organization#GO:0016043;multicellular organismal reproductive process#GO:0048609;anatomical structure development#GO:0048856;sexual reproduction#GO:0019953;biological regulation#GO:0065007;chromatin organization#GO:0006325;cellular process#GO:0009987;regulation of metabolic process#GO:0019222;epigenetic regulation of gene expression#GO:0040029;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;developmental process#GO:0032502 HUMAN|HGNC=37243|UniProtKB=C9JCN9 C9JCN9 HSBP1L1 PTHR19424:SF4 HEAT SHOCK FACTOR BINDING PROTEIN 1 HEAT SHOCK FACTOR-BINDING PROTEIN 1-LIKE PROTEIN 1 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cellular response to heat#GO:0034605;response to heat#GO:0009408;heat acclimation#GO:0010286;response to abiotic stimulus#GO:0009628;response to stress#GO:0006950;response to temperature stimulus#GO:0009266;response to stimulus#GO:0050896;cellular response to stress#GO:0033554 cytosol#GO:0005829;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=14251|UniProtKB=Q8WY22 Q8WY22 BRI3BP PTHR31253:SF0 BRI3-BINDING PROTEIN BRI3-BINDING PROTEIN mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=13823|UniProtKB=Q8TDF5 Q8TDF5 NETO1 PTHR24251:SF27 OVOCHYMASE-RELATED NEUROPILIN AND TOLLOID-LIKE PROTEIN 1 signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515 protein localization to cell junction#GO:1902414;localization within membrane#GO:0051668;cellular localization#GO:0051641;localization#GO:0051179;regulation of biological quality#GO:0065008;regulation of protein localization#GO:0032880;protein localization to membrane#GO:0072657;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;protein localization to organelle#GO:0033365;regulation of postsynaptic membrane neurotransmitter receptor levels#GO:0099072;protein localization to cell periphery#GO:1990778;protein localization to synapse#GO:0035418;intracellular protein localization#GO:0008104;regulation of localization#GO:0032879;macromolecule localization#GO:0033036;cellular process#GO:0009987;regulation of protein localization to membrane#GO:1905475;biological regulation#GO:0065007 postsynaptic density membrane#GO:0098839;postsynaptic density#GO:0014069;postsynaptic specialization membrane#GO:0099634;postsynaptic membrane#GO:0045211;synapse#GO:0045202;cellular anatomical structure#GO:0110165;asymmetric synapse#GO:0032279;organelle#GO:0043226;postsynapse#GO:0098794;cell junction#GO:0030054;synaptic membrane#GO:0097060;plasma membrane#GO:0005886;neuron to neuron synapse#GO:0098984;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;cell periphery#GO:0071944;membrane#GO:0016020 serine protease#PC00203;protease#PC00190 HUMAN|HGNC=7701|UniProtKB=O95139 O95139 NDUFB6 PTHR15083:SF0 NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 6 NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 6 metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091;energy derivation by oxidation of organic compounds#GO:0015980;cellular respiration#GO:0045333;oxidative phosphorylation#GO:0006119;ATP synthesis coupled electron transport#GO:0042773;aerobic respiration#GO:0009060;electron transport chain#GO:0022900;cellular process#GO:0009987;respiratory electron transport chain#GO:0022904;mitochondrial ATP synthesis coupled electron transport#GO:0042775 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;membrane protein complex#GO:0098796;oxidoreductase complex#GO:1990204;membrane#GO:0016020;respiratory chain complex#GO:0098803;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;catalytic complex#GO:1902494;respiratory chain complex I#GO:0045271 dehydrogenase#PC00092 HUMAN|HGNC=14890|UniProtKB=Q9BTF0 Q9BTF0 THUMPD2 PTHR14911:SF1 THUMP DOMAIN-CONTAINING U6 SNRNA (GUANINE-N(2))-METHYLTRANSFERASE THUMPD2 S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;catalytic activity, acting on a tRNA#GO:0140101;tRNA (guanine) methyltransferase activity#GO:0016423;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring one-carbon groups#GO:0016741;RNA methyltransferase activity#GO:0008173;catalytic activity, acting on RNA#GO:0140098;tRNA methyltransferase activity#GO:0008175 tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;tRNA methylation#GO:0030488;methylation#GO:0032259;macromolecule modification#GO:0043412;RNA methylation#GO:0001510;RNA metabolic process#GO:0016070;RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187;macromolecule methylation#GO:0043414;tRNA modification#GO:0006400;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 RNA methyltransferase#PC00033;RNA metabolism protein#PC00031 HUMAN|HGNC=21349|UniProtKB=Q5SZD4 Q5SZD4 GLYATL3 PTHR15298:SF6 L-COA N-ACYLTRANSFERASE-RELATED GLYCINE N-ACYLTRANSFERASE-LIKE PROTEIN 3 acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 acyltransferase#PC00042 HUMAN|HGNC=18053|UniProtKB=Q8TDX9 Q8TDX9 PKD1L1 PTHR10877:SF145 POLYCYSTIN FAMILY MEMBER POLYCYSTIN-1-LIKE PROTEIN 1 metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic cation channel activity#GO:0005261;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;passive transmembrane transporter activity#GO:0022803;calcium ion transmembrane transporter activity#GO:0015085;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324 response to stimulus#GO:0050896;response to external stimulus#GO:0009605;detection of mechanical stimulus#GO:0050982;response to abiotic stimulus#GO:0009628;detection of stimulus#GO:0051606;response to mechanical stimulus#GO:0009612 cellular anatomical structure#GO:0110165;membrane#GO:0016020 ion channel#PC00133 HUMAN|HGNC=4328|UniProtKB=O75311 O75311 GLRA3 PTHR18945:SF455 NEUROTRANSMITTER GATED ION CHANNEL GLYCINE RECEPTOR SUBUNIT ALPHA-3 extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;chloride transmembrane transporter activity#GO:0015108;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;chloride channel activity#GO:0005254;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic anion transmembrane transporter activity#GO:0008509;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;monoatomic anion channel activity#GO:0005253;channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836 establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;chloride transmembrane transport#GO:1902476;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698;chloride transport#GO:0006821;transport#GO:0006810;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220;monoatomic anion transport#GO:0006820;cellular process#GO:0009987 postsynaptic specialization#GO:0099572;organelle#GO:0043226;plasma membrane region#GO:0098590;synapse#GO:0045202;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;postsynapse#GO:0098794;cell periphery#GO:0071944;cell junction#GO:0030054;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;synaptic membrane#GO:0097060 ligand-gated ion channel#PC00141 HUMAN|HGNC=26299|UniProtKB=Q8TEC5 Q8TEC5 SH3RF2 PTHR14167:SF60 SH3 DOMAIN-CONTAINING E3 UBIQUITIN-PROTEIN LIGASE SH3RF2 enzyme binding#GO:0019899;ubiquitin protein ligase activity#GO:0061630;protein-macromolecule adaptor activity#GO:0030674;binding#GO:0005488;phosphatase binding#GO:0019902;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;protein binding#GO:0005515;molecular adaptor activity#GO:0060090;transferase activity#GO:0016740;protein phosphatase binding#GO:0019903;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;positive regulation of JNK cascade#GO:0046330;positive regulation of signaling#GO:0023056;negative regulation of programmed cell death#GO:0043069;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of apoptotic process#GO:0043066;positive regulation of response to stimulus#GO:0048584;positive regulation of intracellular signal transduction#GO:1902533;regulation of MAPK cascade#GO:0043408;regulation of response to stimulus#GO:0048583;regulation of apoptotic process#GO:0042981;negative regulation of cellular process#GO:0048523;regulation of JNK cascade#GO:0046328;positive regulation of MAPK cascade#GO:0043410 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981 scaffold/adaptor protein#PC00226 HUMAN|HGNC=1371|UniProtKB=O43570 O43570 CA12 PTHR18952:SF19 CARBONIC ANHYDRASE CARBONIC ANHYDRASE 12 lyase activity#GO:0016829;carbon-oxygen lyase activity#GO:0016835;hydro-lyase activity#GO:0016836;catalytic activity#GO:0003824 inorganic ion homeostasis#GO:0098771;chemical homeostasis#GO:0048878;monoatomic ion homeostasis#GO:0050801;homeostatic process#GO:0042592 apical part of cell#GO:0045177;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;plasma membrane#GO:0005886;membrane#GO:0016020;basolateral plasma membrane#GO:0016323;basal part of cell#GO:0045178;apical plasma membrane#GO:0016324;cell periphery#GO:0071944;basal plasma membrane#GO:0009925 metabolite interconversion enzyme#PC00262;dehydratase#PC00091 HUMAN|HGNC=15480|UniProtKB=Q9NSV4 Q9NSV4 DIAPH3 PTHR45691:SF9 PROTEIN DIAPHANOUS PROTEIN DIAPHANOUS HOMOLOG 3 actin filament-based process#GO:0030029;supramolecular fiber organization#GO:0097435;protein-containing complex assembly#GO:0065003;protein polymerization#GO:0051258;cellular component organization#GO:0016043;actin filament polymerization#GO:0030041;actin cytoskeleton organization#GO:0030036;actin filament organization#GO:0007015;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;actin polymerization or depolymerization#GO:0008154;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607 cytoskeleton#GO:0005856;actin filament#GO:0005884;intracellular organelle#GO:0043229;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;actin cytoskeleton#GO:0015629;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;organelle#GO:0043226;supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232 cytoskeletal protein#PC00085 Cytoskeletal regulation by Rho GTPase#P00016>mDia#P00510 HUMAN|HGNC=30369|UniProtKB=Q9NXZ1 Q9NXZ1 SAGE1 PTHR12957:SF36 DEAD/H BOX POLYPEPTIDE 26/DICE1-RELATED SAGE1-LIKE PROTEIN-RELATED protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;snRNA processing#GO:0016180;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;snRNA metabolic process#GO:0016073;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA biosynthetic process#GO:0032774;snRNA 3'-end processing#GO:0034472;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;integrator complex#GO:0032039;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634 RNA helicase#PC00032 HUMAN|HGNC=8162|UniProtKB=P58181 P58181 OR10A3 PTHR26453:SF30 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 10A3 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 response to stimulus#GO:0050896;response to chemical#GO:0042221;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;detection of chemical stimulus#GO:0009593;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;system process#GO:0003008;sensory perception#GO:0007600;nervous system process#GO:0050877;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=2395|UniProtKB=P53672 P53672 CRYBA2 PTHR11818:SF7 BETA/GAMMA CRYSTALLIN BETA-CRYSTALLIN A2 structural molecule activity#GO:0005198 anatomical structure development#GO:0048856;system development#GO:0048731;eye development#GO:0001654;camera-type eye development#GO:0043010;animal gross anatomical part developmental process#GO:0160108;sensory perception#GO:0007600;nervous system process#GO:0050877;visual perception#GO:0007601;visual system development#GO:0150063;sensory perception of light stimulus#GO:0050953;multicellular organism development#GO:0007275;animal organ development#GO:0048513;system process#GO:0003008;sensory organ development#GO:0007423;developmental process#GO:0032502;lens development in camera-type eye#GO:0002088;multicellular organismal process#GO:0032501;sensory system development#GO:0048880 structural protein#PC00211 HUMAN|HGNC=11509|UniProtKB=P21579 P21579 SYT1 PTHR10024:SF239 SYNAPTOTAGMIN SYNAPTOTAGMIN-1 molecular sensor activity#GO:0140299;lipid binding#GO:0008289;molecular function regulator activity#GO:0098772;protein binding#GO:0005515;phospholipid binding#GO:0005543;binding#GO:0005488;SNARE binding#GO:0000149 regulated exocytosis#GO:0045055;regulation of localization#GO:0032879;positive regulation of vesicle fusion#GO:0031340;exocytosis#GO:0006887;regulation of transport#GO:0051049;vesicle-mediated transport in synapse#GO:0099003;establishment of localization in cell#GO:0051649;synaptic vesicle exocytosis#GO:0016079;positive regulation of transport#GO:0051050;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;synaptic signaling#GO:0099536;neurotransmitter transport#GO:0006836;regulation of trans-synaptic signaling#GO:0099177;vesicle-mediated transport#GO:0016192;positive regulation of cellular component organization#GO:0051130;regulation of signaling#GO:0023051;regulation of neurotransmitter transport#GO:0051588;secretion by cell#GO:0032940;regulation of secretion by cell#GO:1903530;positive regulation of organelle organization#GO:0010638;cellular localization#GO:0051641;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;regulation of organelle organization#GO:0033043;export from cell#GO:0140352;signaling#GO:0023052;regulation of synaptic vesicle exocytosis#GO:2000300;regulation of cellular component organization#GO:0051128;regulation of neurotransmitter secretion#GO:0046928;transport#GO:0006810;synaptic vesicle cycle#GO:0099504;establishment of localization#GO:0051234;positive regulation of cellular process#GO:0048522;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;neurotransmitter secretion#GO:0007269;signal release#GO:0023061;trans-synaptic signaling#GO:0099537;regulation of exocytosis#GO:0017157;regulation of secretion#GO:0051046;localization#GO:0051179;cell communication#GO:0007154;secretion#GO:0046903;chemical synaptic transmission#GO:0007268;signal release from synapse#GO:0099643;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794 organelle membrane#GO:0031090;transport vesicle#GO:0030133;transport vesicle membrane#GO:0030658;endomembrane system#GO:0012505;plasma membrane#GO:0005886;vesicle membrane#GO:0012506;membrane#GO:0016020;cell periphery#GO:0071944;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;axon#GO:0030424;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;vesicle#GO:0031982;synaptic vesicle membrane#GO:0030672;synaptic vesicle#GO:0008021;cell junction#GO:0030054;bounding membrane of organelle#GO:0098588;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;secretory vesicle#GO:0099503;presynapse#GO:0098793;neuron projection#GO:0043005;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;intracellular vesicle#GO:0097708 membrane trafficking regulatory protein#PC00151 Synaptic vesicle trafficking#P05734>Synaptotagmin#P05769 HUMAN|HGNC=349|UniProtKB=P02765 P02765 AHSG PTHR13814:SF6 FETUIN ALPHA-2-HS-GLYCOPROTEIN endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772;enzyme inhibitor activity#GO:0004857;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;peptidase regulator activity#GO:0061134 defense response#GO:0006952;regulation of response to stimulus#GO:0048583;regulation of response to stress#GO:0080134;regulation of multicellular organismal process#GO:0051239;regulation of bone mineralization#GO:0030500;biological regulation#GO:0065007;regulation of response to external stimulus#GO:0032101;response to stress#GO:0006950;acute inflammatory response#GO:0002526;regulation of defense response#GO:0031347;regulation of inflammatory response#GO:0050727;inflammatory response#GO:0006954;regulation of developmental process#GO:0050793;response to stimulus#GO:0050896;regulation of multicellular organismal development#GO:2000026;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of multicellular organismal process#GO:0051241 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012 protease inhibitor#PC00191 HUMAN|HGNC=37167|UniProtKB=P0CJ77 P0CJ77 MTRNR2L10 PTHR33895:SF3 HUMANIN-LIKE 4 HUMANIN-LIKE 10 signaling receptor inhibitor activity#GO:0030547;molecular function regulator activity#GO:0098772;molecular function inhibitor activity#GO:0140678;signaling receptor regulator activity#GO:0030545 biological regulation#GO:0065007;regulation of cellular process#GO:0050794;negative regulation of apoptotic process#GO:0043066;negative regulation of programmed cell death#GO:0043069;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;regulation of apoptotic process#GO:0042981;negative regulation of cellular process#GO:0048523 HUMAN|HGNC=10306|UniProtKB=P61313 P61313 RPL15 PTHR11847:SF4 RIBOSOMAL PROTEIN L15 LARGE RIBOSOMAL SUBUNIT PROTEIN EL15 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 translation#GO:0006412;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;cytoplasmic translation#GO:0002181 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytosolic large ribosomal subunit#GO:0022625;cytosolic ribosome#GO:0022626;cytosol#GO:0005829;ribosome#GO:0005840;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229 translational protein#PC00263;ribosomal protein#PC00202 HUMAN|HGNC=50767|UniProtKB=A0A0J9YXQ4 A0A0J9YXQ4 PNMA6E PTHR23095:SF20 PARANEOPLASTIC ANTIGEN PARANEOPLASTIC ANTIGEN MA6E transcription cofactor#PC00217 HUMAN|HGNC=9542|UniProtKB=P28074 P28074 PSMB5 PTHR11599:SF51 PROTEASOME SUBUNIT ALPHA/BETA PROTEASOME SUBUNIT BETA TYPE-5 catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175 cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cytosol#GO:0005829;proteasome complex#GO:0000502;nucleus#GO:0005634;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;peptidase complex#GO:1905368;endopeptidase complex#GO:1905369;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 protein modifying enzyme#PC00260;protease#PC00190 HUMAN|HGNC=26883|UniProtKB=Q8N7L0 Q8N7L0 FAM216B PTHR16476:SF3 FAMILY WITH SEQUENCE SIMILARITY 216 MEMBER A PROTEIN FAM216B HUMAN|HGNC=14079|UniProtKB=Q9UGM1 Q9UGM1 CHRNA9 PTHR18945:SF489 NEUROTRANSMITTER GATED ION CHANNEL NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-9 channel activity#GO:0015267;molecular transducer activity#GO:0060089;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation channel activity#GO:0005261;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;ligand-gated monoatomic cation channel activity#GO:0099094;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;transmembrane transporter activity#GO:0022857;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;monoatomic cation transmembrane transporter activity#GO:0008324;transmembrane signaling receptor activity#GO:0004888;gated channel activity#GO:0022836;postsynaptic neurotransmitter receptor activity#GO:0098960;signaling receptor activity#GO:0038023;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;transporter activity#GO:0005215;neurotransmitter receptor activity#GO:0030594 transport#GO:0006810;calcium ion transport#GO:0006816;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;cellular process#GO:0009987;synaptic signaling#GO:0099536;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;synaptic transmission, cholinergic#GO:0007271;trans-synaptic signaling#GO:0099537;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;localization#GO:0051179;cell communication#GO:0007154;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;metal ion transport#GO:0030001;membrane depolarization#GO:0051899;signaling#GO:0023052;anterograde trans-synaptic signaling#GO:0098916 membrane protein complex#GO:0098796;membrane#GO:0016020;cell periphery#GO:0071944;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351 ligand-gated ion channel#PC00141 Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086;Nicotinic acetylcholine receptor signaling pathway#P00044>alpha#P01088 HUMAN|HGNC=9408|UniProtKB=O94806 O94806 PRKD3 PTHR22968:SF26 PROTEIN KINASE C, MU SERINE_THREONINE-PROTEIN KINASE D3 protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;G protein-coupled receptor signaling pathway#GO:0007186;phospholipase C-activating G protein-coupled receptor signaling pathway#GO:0007200;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 EGF receptor signaling pathway#P00018>PKC#P00565;VEGF signaling pathway#P00056>PKC#P01425;Angiogenesis#P00005>PKC#P00219 HUMAN|HGNC=29075|UniProtKB=O60320 O60320 ENTREP2 PTHR17615:SF6 PROTEIN FAM189A PROTEIN ENTREP2 HUMAN|HGNC=4948|UniProtKB=P01911 P01911 HLA-DRB1 PTHR19944:SF108 MHC CLASS II-RELATED HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DRB1 BETA CHAIN protein-containing complex binding#GO:0044877;binding#GO:0005488;peptide binding#GO:0042277;antigen binding#GO:0003823 regulation of leukocyte cell-cell adhesion#GO:1903037;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;regulation of cell adhesion#GO:0030155;positive regulation of response to stimulus#GO:0048584;positive regulation of cell activation#GO:0050867;biological regulation#GO:0065007;positive regulation of leukocyte cell-cell adhesion#GO:1903039;positive regulation of cellular process#GO:0048522;antigen processing and presentation#GO:0019882;positive regulation of lymphocyte activation#GO:0051251;regulation of immune response#GO:0050776;regulation of cellular process#GO:0050794;regulation of cell-cell adhesion#GO:0022407;regulation of immune system process#GO:0002682;positive regulation of cell adhesion#GO:0045785;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;positive regulation of leukocyte activation#GO:0002696;regulation of T cell activation#GO:0050863;cellular component assembly#GO:0022607;positive regulation of T cell activation#GO:0050870;regulation of multicellular organismal process#GO:0051239;positive regulation of immune system process#GO:0002684;positive regulation of cell-cell adhesion#GO:0022409;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;immune system process#GO:0002376;regulation of lymphocyte activation#GO:0051249;cellular component organization#GO:0016043;regulation of leukocyte activation#GO:0002694;regulation of cell activation#GO:0050865;positive regulation of multicellular organismal process#GO:0051240;protein-containing complex assembly#GO:0065003;regulation of biological process#GO:0050789 cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;late endosome#GO:0005770;endomembrane system#GO:0012505;cytoplasm#GO:0005737;plasma membrane#GO:0005886;vacuole#GO:0005773;membrane#GO:0016020;vesicle membrane#GO:0012506;lysosomal membrane#GO:0005765;cell periphery#GO:0071944;vacuolar membrane#GO:0005774;lytic vacuole#GO:0000323;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;late endosome membrane#GO:0031902;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;lytic vacuole membrane#GO:0098852;lysosome#GO:0005764;plasma membrane protein complex#GO:0098797;vesicle#GO:0031982;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;endosome membrane#GO:0010008;intracellular organelle#GO:0043229 major histocompatibility complex protein#PC00149 HUMAN|HGNC=29381|UniProtKB=Q9BRK4 Q9BRK4 LZTS2 PTHR19354:SF4 ZIPPER PUTATIVE TUMOR SUPPRESSOR 2 HOMOLOG-LIKE PROTEIN-RELATED ZIPPER PUTATIVE TUMOR SUPPRESSOR 2-RELATED negative regulation of cell communication#GO:0010648;negative regulation of canonical Wnt signaling pathway#GO:0090090;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;regulation of cellular process#GO:0050794;regulation of Wnt signaling pathway#GO:0030111;regulation of cell communication#GO:0010646;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;negative regulation of response to stimulus#GO:0048585;negative regulation of Wnt signaling pathway#GO:0030178;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;regulation of canonical Wnt signaling pathway#GO:0060828 HUMAN|HGNC=21657|UniProtKB=Q86SG5 Q86SG5 S100A7A PTHR11639:SF146 S100 CALCIUM-BINDING PROTEIN PROTEIN S100-A7A cation binding#GO:0043169;protein binding#GO:0005515;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094 endothelial cell migration#GO:0043542;cell migration#GO:0016477;cell motility#GO:0048870;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 calmodulin-related#PC00061;calcium-binding protein#PC00060 HUMAN|HGNC=2192|UniProtKB=P39059 P39059 COL15A1 PTHR24023:SF912 COLLAGEN ALPHA COLLAGEN ALPHA-1(XV) CHAIN extracellular matrix structural constituent#GO:0005201;structural molecule activity#GO:0005198 cellular process#GO:0009987;extracellular structure organization#GO:0043062;cellular component organization#GO:0016043;external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840 cellular anatomical structure#GO:0110165;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;basement membrane#GO:0005604;extracellular region#GO:0005576 extracellular matrix structural protein#PC00103;extracellular matrix protein#PC00102 Integrin signalling pathway#P00034>Collagen#P00922 HUMAN|HGNC=14059|UniProtKB=Q96J87 Q96J87 CELF6 PTHR24012:SF716 RNA BINDING PROTEIN CUGBP ELAV-LIKE FAMILY MEMBER 6 RNA binding#GO:0003723;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488 RNA processing#GO:0006396;mRNA splice site recognition#GO:0006376;cellular component assembly#GO:0022607;gene expression#GO:0010467;cellular process#GO:0009987;mRNA processing#GO:0006397;cellular component biogenesis#GO:0044085;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;regulation of mRNA metabolic process#GO:1903311;protein-RNA complex organization#GO:0071826;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;mRNA metabolic process#GO:0016071;ribonucleoprotein complex biogenesis#GO:0022613;protein-containing complex assembly#GO:0065003;mRNA splicing, via spliceosome#GO:0000398;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;regulation of alternative mRNA splicing, via spliceosome#GO:0000381;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;spliceosomal complex assembly#GO:0000245;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;regulation of RNA splicing#GO:0043484;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of mRNA processing#GO:0050684;macromolecule biosynthetic process#GO:0009059;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;RNA biosynthetic process#GO:0032774;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of mRNA splicing, via spliceosome#GO:0048024;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of RNA metabolic process#GO:0051252;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;protein-RNA complex assembly#GO:0022618;RNA splicing, via transesterification reactions#GO:0000375 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904 RNA metabolism protein#PC00031 HUMAN|HGNC=16777|UniProtKB=Q9BYS1 Q9BYS1 KRTAP1-5 PTHR23262:SF195 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 1-5 structural protein#PC00211 HUMAN|HGNC=14953|UniProtKB=Q9NXH3 Q9NXH3 PPP1R14D PTHR16188:SF13 PROTEIN PHOSPHATASE 1 INHIBITOR POTENTIATED BY PROTEIN KINASE C PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 14D enzyme regulator activity#GO:0030234;protein phosphatase regulator activity#GO:0019888;molecular function inhibitor activity#GO:0140678;protein serine/threonine phosphatase inhibitor activity#GO:0004865;phosphatase regulator activity#GO:0019208;molecular function regulator activity#GO:0098772;phosphatase inhibitor activity#GO:0019212;protein phosphatase inhibitor activity#GO:0004864;enzyme inhibitor activity#GO:0004857 phosphatase modulator#PC00184 HUMAN|HGNC=17418|UniProtKB=A8MXT2 A8MXT2 MAGEB17 PTHR11736:SF88 MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN MELANOMA-ASSOCIATED ANTIGEN B17 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of metabolic process#GO:0009892;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 scaffold/adaptor protein#PC00226 HUMAN|HGNC=6361|UniProtKB=Q9UKR3 Q9UKR3 KLK13 PTHR24271:SF3 KALLIKREIN-RELATED KALLIKREIN-13 catalytic activity#GO:0003824;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;serine-type peptidase activity#GO:0008236;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787 metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058 extracellular region#GO:0005576;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;vesicle#GO:0031982;secretory vesicle#GO:0099503;intracellular vesicle#GO:0097708;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226 serine protease#PC00203 HUMAN|HGNC=23387|UniProtKB=Q76FK4 Q76FK4 NOL8 PTHR48029:SF2 NUCLEOLAR PROTEIN 8 NUCLEOLAR PROTEIN 8 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 protein localization to nucleus#GO:0034504;macromolecule localization#GO:0033036;protein localization to organelle#GO:0033365;localization#GO:0051179;intracellular protein localization#GO:0008104 organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 HUMAN|HGNC=26922|UniProtKB=Q5T890 Q5T890 ERCC6L2 PTHR45629:SF14 SNF2/RAD54 FAMILY MEMBER DNA EXCISION REPAIR PROTEIN ERCC-6-LIKE 2 response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139;interstrand cross-link repair#GO:0036297;primary metabolic process#GO:0044238;response to stress#GO:0006950;nucleic acid metabolic process#GO:0090304;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA damage response#GO:0006974;cellular response to stress#GO:0033554 damaged DNA-binding protein#PC00086 HUMAN|HGNC=18752|UniProtKB=Q9BPZ7 Q9BPZ7 MAPKAP1 PTHR13335:SF1 TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1 TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1 phospholipid binding#GO:0005543;phosphatidylinositol phosphate binding#GO:1901981;small molecule binding#GO:0036094;binding#GO:0005488;anion binding#GO:0043168;ion binding#GO:0043167;phosphatidylinositol-4,5-bisphosphate binding#GO:0005546;phosphatidylinositol bisphosphate binding#GO:1902936;lipid binding#GO:0008289 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;TORC2 signaling#GO:0038203;TOR signaling#GO:0031929;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 cell periphery#GO:0071944;membrane#GO:0016020;cytoplasm#GO:0005737;TOR complex#GO:0038201;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HUMAN|HGNC=11046|UniProtKB=Q9NSD5 Q9NSD5 SLC6A13 PTHR11616:SF111 SODIUM/CHLORIDE DEPENDENT TRANSPORTER SODIUM- AND CHLORIDE-DEPENDENT GABA TRANSPORTER 2 carboxylic acid transmembrane transporter activity#GO:0046943;amino acid:sodium symporter activity#GO:0005283;solute:sodium symporter activity#GO:0015370;transmembrane transporter activity#GO:0022857;chloride transmembrane transporter activity#GO:0015108;sodium ion transmembrane transporter activity#GO:0015081;active transmembrane transporter activity#GO:0022804;solute:monoatomic cation symporter activity#GO:0015294;symporter activity#GO:0015293;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic anion transmembrane transporter activity#GO:0008509;secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;amino acid transmembrane transporter activity#GO:0015171;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075 sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;amino acid transport#GO:0006865;monoatomic cation transport#GO:0006812;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cell projection#GO:0042995;cellular anatomical structure#GO:0110165 primary active transporter#PC00068 HUMAN|HGNC=33451|UniProtKB=Q6PK04 Q6PK04 CCDC137 PTHR21838:SF2 COILED-COIL DOMAIN-CONTAINING PROTEIN 137 COILED-COIL DOMAIN-CONTAINING PROTEIN 137 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=10333|UniProtKB=P62888 P62888 RPL30 PTHR11449:SF1 RIBOSOMAL PROTEIN L30 LARGE RIBOSOMAL SUBUNIT PROTEIN EL30 RNA binding#GO:0003723;structural molecule activity#GO:0005198;binding#GO:0005488;nucleic acid binding#GO:0003676;structural constituent of ribosome#GO:0003735 ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;ribosome#GO:0005840;cytosol#GO:0005829;cytosolic large ribosomal subunit#GO:0022625;cytosolic ribosome#GO:0022626;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934 translational protein#PC00263;ribosomal protein#PC00202 HUMAN|HGNC=14098|UniProtKB=Q9GZL7 Q9GZL7 WDR12 PTHR19855:SF40 WD40 REPEAT PROTEIN 12, 37 RIBOSOME BIOGENESIS PROTEIN WDR12 RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;ribosome biogenesis#GO:0042254;ribosomal large subunit biogenesis#GO:0042273;nucleic acid biosynthetic process#GO:0141187;ribonucleoprotein complex biogenesis#GO:0022613;maturation of 5.8S rRNA#GO:0000460;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;maturation of LSU-rRNA#GO:0000470;gene expression#GO:0010467;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;preribosome, large subunit precursor#GO:0030687;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;preribosome#GO:0030684;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;90S preribosome#GO:0030686;organelle lumen#GO:0043233 HUMAN|HGNC=10785|UniProtKB=P84103 P84103 SRSF3 PTHR23147:SF121 SERINE/ARGININE RICH SPLICING FACTOR SERINE_ARGININE-RICH SPLICING FACTOR 3 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear speck#GO:0016607;organelle lumen#GO:0043233;membraneless organelle#GO:0043228;nuclear body#GO:0016604;intracellular membraneless organelle#GO:0043232;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974 RNA processing factor#PC00147;RNA metabolism protein#PC00031;RNA splicing factor#PC00148 HUMAN|HGNC=31012|UniProtKB=Q8WW24 Q8WW24 TEKT4 PTHR19960:SF12 TEKTIN TEKTIN-4 microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection assembly#GO:0120031;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cellular process#GO:0009987;cell projection assembly#GO:0030031;cilium movement involved in cell motility#GO:0060294;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cilium organization#GO:0044782;cilium-dependent cell motility#GO:0060285;cilium or flagellum-dependent cell motility#GO:0001539;cilium movement#GO:0003341;organelle assembly#GO:0070925;microtubule-based movement#GO:0007018;cell motility#GO:0048870;cell projection organization#GO:0030030;cilium assembly#GO:0060271;cellular component organization#GO:0016043 microtubule cytoskeleton#GO:0015630;organelle#GO:0043226;motile cilium#GO:0031514;sperm flagellum#GO:0036126;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;plasma membrane bounded cell projection#GO:0120025;cytoskeleton#GO:0005856;9+2 motile cilium#GO:0097729;intracellular organelle#GO:0043229;cilium#GO:0005929;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 non-motor microtubule binding protein#PC00166;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=16854|UniProtKB=Q9Y4G8 Q9Y4G8 RAPGEF2 PTHR23113:SF217 GUANINE NUCLEOTIDE EXCHANGE FACTOR RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 2 guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234 cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;neuron differentiation#GO:0030182;nervous system development#GO:0007399;intracellular signaling cassette#GO:0141124;signal transduction#GO:0007165;cellular process#GO:0009987;neuron projection development#GO:0031175;neuron development#GO:0048666;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;signaling#GO:0023052;cell development#GO:0048468;cell projection organization#GO:0030030;response to stimulus#GO:0050896;cell differentiation#GO:0030154;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;developmental process#GO:0032502;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;plasma membrane bounded cell projection organization#GO:0120036;multicellular organismal process#GO:0032501;system development#GO:0048731;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;anatomical structure development#GO:0048856;Ras protein signal transduction#GO:0007265;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716 apical plasma membrane#GO:0016324;intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;endocytic vesicle#GO:0030139;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane region#GO:0098590;plasma membrane#GO:0005886;cytoplasm#GO:0005737;apical part of cell#GO:0045177 guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=21144|UniProtKB=Q9UL01 Q9UL01 DSE PTHR15532:SF3 FAMILY NOT NAMED DERMATAN-SULFATE EPIMERASE racemase and epimerase activity#GO:0016854;racemase and epimerase activity, acting on carbohydrates and derivatives#GO:0016857;catalytic activity#GO:0003824;isomerase activity#GO:0016853 primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;chondroitin sulfate proteoglycan metabolic process#GO:0050654;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;proteoglycan metabolic process#GO:0006029;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100 HUMAN|HGNC=24933|UniProtKB=Q6UXH0 Q6UXH0 ANGPTL8 PTHR21463:SF0 ANGIOPOIETIN-LIKE PROTEIN 8 ANGIOPOIETIN-LIKE PROTEIN 8 hormone activity#GO:0005179;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;homeostatic process#GO:0042592;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;lipid homeostasis#GO:0055088;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of lipid metabolic process#GO:0019216;triglyceride homeostasis#GO:0070328;chemical homeostasis#GO:0048878 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=26167|UniProtKB=Q86UB9 Q86UB9 TMEM135 PTHR12459:SF27 TRANSMEMBRANE PROTEIN 135-RELATED TRANSMEMBRANE PROTEIN 135 HUMAN|HGNC=21648|UniProtKB=Q9P0U1 Q9P0U1 TOMM7 PTHR46722:SF1 MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM7 HOMOLOG MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM7 HOMOLOG regulation of localization#GO:0032879;regulation of protein localization#GO:0032880;biological regulation#GO:0065007;positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;membrane protein complex#GO:0098796;organelle envelope#GO:0031967;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;outer membrane#GO:0019867;cytoplasm#GO:0005737;organelle outer membrane#GO:0031968;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;membrane#GO:0016020;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;mitochondrial outer membrane#GO:0005741;mitochondrial outer membrane translocase complex#GO:0005742 primary active transporter#PC00068 HUMAN|HGNC=21697|UniProtKB=Q9BXJ8 Q9BXJ8 TMEM120A PTHR21433:SF1 TRANSMEMBRANE PROTEIN INDUCED BY TUMOR NECROSIS FACTOR ALPHA TRANSMEMBRANE PROTEIN 120A cell differentiation#GO:0030154;cellular developmental process#GO:0048869;developmental process#GO:0032502;cellular process#GO:0009987;fat cell differentiation#GO:0045444 intracellular organelle#GO:0043229;nuclear inner membrane#GO:0005637;membrane-bounded organelle#GO:0043227;nuclear membrane#GO:0031965;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;organelle envelope#GO:0031967;membrane#GO:0016020;nucleus#GO:0005634;organelle inner membrane#GO:0019866;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=8760|UniProtKB=Q15116 Q15116 PDCD1 PTHR15264:SF2 PROGRAMMED CELL DEATH PROTEIN 1 PROGRAMMED CELL DEATH PROTEIN 1 biological regulation#GO:0065007;regulation of immune system process#GO:0002682;regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;regulation of immune response#GO:0050776 cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897 HUMAN|Ensembl=ENSG00000276345.1|UniProtKB=A0AAG2SUK6 A0AAG2SUK6 PTHR12059:SF5 RIBOSOMAL PROTEIN L23-RELATED LARGE RIBOSOMAL SUBUNIT PROTEIN UL23M structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 metabolic process#GO:0008152;translation#GO:0006412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;mitochondrial gene expression#GO:0140053;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;mitochondrial translation#GO:0032543;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058 mitochondrial ribosome#GO:0005761;intracellular anatomical structure#GO:0005622;organellar ribosome#GO:0000313;membrane-bounded organelle#GO:0043227;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;mitochondrion#GO:0005739;organelle lumen#GO:0043233;membraneless organelle#GO:0043228;mitochondrial large ribosomal subunit#GO:0005762;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;membrane-enclosed lumen#GO:0031974 ribosomal protein#PC00202 HUMAN|HGNC=395|UniProtKB=P13716 P13716 ALAD PTHR11458:SF0 DELTA-AMINOLEVULINIC ACID DEHYDRATASE DELTA-AMINOLEVULINIC ACID DEHYDRATASE catalytic activity#GO:0003824;hydro-lyase activity#GO:0016836;carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829 pigment biosynthetic process#GO:0046148;porphyrin-containing compound metabolic process#GO:0006778;tetrapyrrole metabolic process#GO:0033013;metabolic process#GO:0008152;porphyrin-containing compound biosynthetic process#GO:0006779;cellular process#GO:0009987;pigment metabolic process#GO:0042440;heme biosynthetic process#GO:0006783;biosynthetic process#GO:0009058;heme metabolic process#GO:0042168;tetrapyrrole biosynthetic process#GO:0033014 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 dehydratase#PC00091 Heme biosynthesis#P02746>porphobilinogen synthase#P02979 HUMAN|HGNC=5830|UniProtKB=A0A0C4DH90 A0A0C4DH90 IGKV3OR2-268 PTHR23267:SF331 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN KAPPA VARIABLE 3-15-RELATED immune response#GO:0006955;immune system process#GO:0002376;response to stimulus#GO:0050896 protein-containing complex#GO:0032991 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=37222|UniProtKB=P86480 P86480 PRR20D PTHR38819:SF1 PROLINE-RICH PROTEIN 20A-RELATED PROLINE-RICH PROTEIN 20A-RELATED HUMAN|HGNC=27379|UniProtKB=Q8IUW5 Q8IUW5 RELL1 PTHR31037:SF1 RELT-LIKE PROTEIN 1-RELATED RELT-LIKE PROTEIN 1 regulation of response to stimulus#GO:0048583;regulation of MAPK cascade#GO:0043408;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of MAPK cascade#GO:0043410;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of response to stimulus#GO:0048584;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HUMAN|HGNC=20410|UniProtKB=Q8TE96 Q8TE96 DQX1 PTHR18934:SF108 ATP-DEPENDENT RNA HELICASE ATP-DEPENDENT RNA HELICASE HOMOLOG DQX1 RNA binding#GO:0003723;ATP-dependent activity#GO:0140657;nucleic acid binding#GO:0003676;binding#GO:0005488;isomerase activity#GO:0016853;helicase activity#GO:0004386;macromolecular conformation isomerase activity#GO:0120543;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity#GO:0003824 spliceosomal complex#GO:0005681;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 RNA helicase#PC00032;RNA metabolism protein#PC00031 HUMAN|HGNC=29158|UniProtKB=Q9Y2G9 Q9Y2G9 SBNO2 PTHR12706:SF5 STRAWBERRY NOTCH-RELATED PROTEIN STRAWBERRY NOTCH HOMOLOG 2 protein binding#GO:0005515;DNA binding#GO:0003677;nucleic acid binding#GO:0003676;binding#GO:0005488;histone binding#GO:0042393;chromatin DNA binding#GO:0031490;chromatin binding#GO:0003682 negative regulation of nucleobase-containing compound metabolic process#GO:0045934;positive regulation of macromolecule biosynthetic process#GO:0010557;immune system process#GO:0002376;cell development#GO:0048468;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;myeloid cell differentiation#GO:0030099;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;leukocyte activation involved in immune response#GO:0002366;negative regulation of RNA metabolic process#GO:0051253;positive regulation of macromolecule metabolic process#GO:0010604;regulation of response to external stimulus#GO:0032101;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;osteoclast differentiation#GO:0030316;regulation of RNA metabolic process#GO:0051252;anatomical structure development#GO:0048856;regulation of defense response#GO:0031347;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biosynthetic process#GO:0009889;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;multicellular organismal process#GO:0032501;immune response#GO:0006955;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;response to peptide#GO:1901652;cell activation involved in immune response#GO:0002263;positive regulation of metabolic process#GO:0009893;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of metabolic process#GO:0009892;cell differentiation#GO:0030154;leukocyte differentiation#GO:0002521;negative regulation of RNA biosynthetic process#GO:1902679;immune effector process#GO:0002252;positive regulation of transcription by RNA polymerase II#GO:0045944;response to cytokine#GO:0034097;myeloid leukocyte activation#GO:0002274;response to chemical#GO:0042221;negative regulation of macromolecule biosynthetic process#GO:0010558;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;cell activation#GO:0001775;regulation of inflammatory response#GO:0050727;leukocyte activation#GO:0045321;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;macrophage activation#GO:0042116;developmental process#GO:0032502;regulation of response to stress#GO:0080134;regulation of RNA biosynthetic process#GO:2001141;hemopoiesis#GO:0030097;positive regulation of RNA biosynthetic process#GO:1902680;regulation of macromolecule biosynthetic process#GO:0010556 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=9646|UniProtKB=Q12923 Q12923 PTPN13 PTHR46900:SF1 TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 13 TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 13 phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoprotein phosphatase activity#GO:0004721;protein tyrosine phosphatase activity#GO:0004725;protein binding#GO:0005515;hydrolase activity#GO:0016787;phosphatidylinositol 3-kinase binding#GO:0043548;binding#GO:0005488 regulation of multicellular organismal development#GO:2000026;regulation of biological process#GO:0050789;negative regulation of cellular component organization#GO:0051129;negative regulation of multicellular organismal process#GO:0051241;negative regulation of biological process#GO:0048519;regulation of cellular component biogenesis#GO:0044087;regulation of cell communication#GO:0010646;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of signaling#GO:0023051;regulation of synapse organization#GO:0050807;regulation of cell junction assembly#GO:1901888;regulation of intracellular signal transduction#GO:1902531;regulation of biological quality#GO:0065008;regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051896;regulation of nervous system development#GO:0051960;regulation of synapse structure or activity#GO:0050803;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of synapse assembly#GO:0051963;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 protein phosphatase#PC00195 HUMAN|HGNC=32166|UniProtKB=A6NFQ7 A6NFQ7 DPRX PTHR45793:SF15 HOMEOBOX PROTEIN DIVERGENT PAIRED-RELATED HOMEOBOX sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=575|UniProtKB=Q9Y587 Q9Y587 AP4S1 PTHR11753:SF4 ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY AP-4 COMPLEX SUBUNIT SIGMA-1 vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810;cellular process#GO:0009987 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229 vesicle coat protein#PC00235;membrane traffic protein#PC00150 HUMAN|HGNC=36404|UniProtKB=Q8NHW5 Q8NHW5 RPLP0P6 PTHR45699:SF1 60S ACIDIC RIBOSOMAL PROTEIN P0 LARGE RIBOSOMAL SUBUNIT PROTEIN UL10-RELATED structural molecule activity#GO:0005198;RNA binding#GO:0003723;structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;rRNA binding#GO:0019843;binding#GO:0005488 translation#GO:0006412;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;cytoplasmic translation#GO:0002181;protein biosynthetic process#GO:0160307;gene expression#GO:0010467 cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;ribosome#GO:0005840;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904 ribosomal protein#PC00202;translational protein#PC00263 HUMAN|HGNC=19323|UniProtKB=Q96HU8 Q96HU8 DIRAS2 PTHR24070:SF178 RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY GTP-BINDING PROTEIN DI-RAS2 hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;signaling#GO:0023052;intracellular signaling cassette#GO:0141124;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 small GTPase#PC00208 HUMAN|HGNC=10640|UniProtKB=O95715 O95715 CXCL14 PTHR12015:SF202 SMALL INDUCIBLE CYTOKINE A C-X-C MOTIF CHEMOKINE 14 immune system process#GO:0002376;humoral immune response#GO:0006959;antimicrobial humoral response#GO:0019730;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;response to external stimulus#GO:0009605;defense response#GO:0006952;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;immune response#GO:0006955;defense response to symbiont#GO:0140546;response to stimulus#GO:0050896;defense response to other organism#GO:0098542;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to other organism#GO:0051707 cytokine#PC00083 HUMAN|HGNC=21168|UniProtKB=Q8IXI2 Q8IXI2 RHOT1 PTHR24072:SF124 RHO FAMILY GTPASE MITOCHONDRIAL RHO GTPASE 1 ion binding#GO:0043167;GTPase activity#GO:0003924;small molecule binding#GO:0036094;anion binding#GO:0043168;hydrolase activity#GO:0016787;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;guanyl nucleotide binding#GO:0019001;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555 regulation of membrane permeability#GO:0090559;organelle transport along microtubule#GO:0072384;apoptotic mitochondrial changes#GO:0008637;mitochondrion organization#GO:0007005;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;signal transduction#GO:0007165;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;establishment of organelle localization#GO:0051656;response to stimulus#GO:0050896;signaling#GO:0023052;cellular component organization#GO:0016043;apoptotic process#GO:0006915;regulation of biological process#GO:0050789;cellular localization#GO:0051641;regulation of biological quality#GO:0065008;microtubule-based transport#GO:0099111;cytoskeleton-dependent intracellular transport#GO:0030705;regulation of mitochondrial membrane permeability#GO:0046902;biological regulation#GO:0065007;apoptotic signaling pathway#GO:0097190;transport along microtubule#GO:0010970;establishment of localization#GO:0051234;mitochondrion localization#GO:0051646;actin filament organization#GO:0007015;intracellular transport#GO:0046907;transport#GO:0006810;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;microtubule-based movement#GO:0007018;programmed cell death#GO:0012501;cellular response to stimulus#GO:0051716;cell death#GO:0008219;cell communication#GO:0007154;localization#GO:0051179;supramolecular fiber organization#GO:0097435;organelle localization#GO:0051640;actin filament-based process#GO:0030029 organelle outer membrane#GO:0031968;cytoplasm#GO:0005737;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;mitochondrial outer membrane#GO:0005741;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;outer membrane#GO:0019867;intracellular organelle#GO:0043229 small GTPase#PC00208;G-protein#PC00020 HUMAN|HGNC=27016|UniProtKB=A1KXE4 A1KXE4 FAM168B PTHR31844:SF2 MYELIN-ASSOCIATED NEURITE-OUTGROWTH INHIBITOR-RELATED MYELIN-ASSOCIATED NEURITE-OUTGROWTH INHIBITOR myelin protein#PC00161;structural protein#PC00211 HUMAN|HGNC=18994|UniProtKB=Q8TDC3 Q8TDC3 BRSK1 PTHR24343:SF130 SERINE/THREONINE KINASE SERINE_THREONINE-PROTEIN KINASE BRSK1 catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 cell cycle#GO:0007049;establishment of cell polarity#GO:0030010;mitotic cell cycle#GO:0000278;G2/M transition of mitotic cell cycle#GO:0000086;cell cycle phase transition#GO:0044770;mitotic cell cycle phase transition#GO:0044772;anatomical structure development#GO:0048856;system development#GO:0048731;axon development#GO:0061564;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;cellular developmental process#GO:0048869;mitotic cell cycle process#GO:1903047;neurogenesis#GO:0022008;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cell cycle process#GO:0022402;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell morphogenesis#GO:0000902;cell development#GO:0048468;establishment or maintenance of cell polarity#GO:0007163;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;neuron development#GO:0048666;axonogenesis#GO:0007409;neuron projection development#GO:0031175;cell cycle G2/M phase transition#GO:0044839;cellular process#GO:0009987;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cell projection morphogenesis#GO:0048858 microtubule cytoskeleton#GO:0015630;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;centrosome#GO:0005813;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=3491|UniProtKB=O00321 O00321 ETV2 PTHR11849:SF209 ETS ETS TRANSLOCATION VARIANT 2 DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;developmental process#GO:0032502;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;cellular process#GO:0009987 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;winged helix/forkhead transcription factor#PC00246 PDGF signaling pathway#P00047>Ets#P01167 HUMAN|HGNC=2291|UniProtKB=P24311 P24311 COX7B PTHR16716:SF0 CYTOCHROME C OXIDASE SUBUNIT 7B, MITOCHONDRIAL CYTOCHROME C OXIDASE SUBUNIT 7B, MITOCHONDRIAL mitochondrion#GO:0005739;cytochrome complex#GO:0070069;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;respiratory chain complex IV#GO:0045277;transmembrane transporter complex#GO:1902495;respiratory chain complex#GO:0098803;membrane#GO:0016020;oxidoreductase complex#GO:1990204;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;transporter complex#GO:1990351 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262;oxidase#PC00175 HUMAN|HGNC=24644|UniProtKB=Q9UPR3 Q9UPR3 SMG5 PTHR15696:SF39 SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7 NONSENSE-MEDIATED MRNA DECAY FACTOR SMG5 DNA binding#GO:0003677;RNA binding#GO:0003723;telomeric repeat DNA binding#GO:0042162;sequence-specific DNA binding#GO:0043565;binding#GO:0005488;nucleic acid binding#GO:0003676 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay#GO:0000184;metabolic process#GO:0008152;negative regulation of cellular process#GO:0048523;macromolecule catabolic process#GO:0009057;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;nucleic acid catabolic process#GO:0141188;cellular process#GO:0009987;mRNA catabolic process#GO:0006402;nucleobase-containing compound catabolic process#GO:0034655;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;RNA catabolic process#GO:0006401;RNA metabolic process#GO:0016070;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ribonucleoprotein complex#GO:1990904 RNA metabolism protein#PC00031 HUMAN|HGNC=14731|UniProtKB=Q96R72 Q96R72 OR4K3 PTHR48002:SF184 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 4K3 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=17586|UniProtKB=Q9NZJ7 Q9NZJ7 MTCH1 PTHR10780:SF3 MITOCHONDRIAL CARRIER HOMOLOG MITOCHONDRIAL CARRIER HOMOLOG 1 membrane insertase activity#GO:0032977;protein carrier activity#GO:0140597;molecular carrier activity#GO:0140104 regulation of apoptotic process#GO:0042981;positive regulation of apoptotic process#GO:0043065;establishment of protein localization to organelle#GO:0072594;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;organelle organization#GO:0006996;establishment of protein localization to membrane#GO:0090150;positive regulation of biological process#GO:0048518;mitochondrial membrane organization#GO:0007006;establishment of localization in cell#GO:0051649;positive regulation of cellular process#GO:0048522;establishment of protein localization#GO:0045184;cellular process#GO:0009987;protein insertion into membrane#GO:0051205;biological regulation#GO:0065007;membrane organization#GO:0061024;mitochondrion organization#GO:0007005;localization within membrane#GO:0051668;protein insertion into mitochondrial outer membrane#GO:0045040;localization#GO:0051179;cellular localization#GO:0051641;regulation of programmed cell death#GO:0043067;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;protein localization to mitochondrion#GO:0070585;positive regulation of programmed cell death#GO:0043068;regulation of cellular process#GO:0050794;protein localization to organelle#GO:0033365 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;organelle envelope#GO:0031967;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;outer membrane#GO:0019867;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;organelle outer membrane#GO:0031968;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;membrane#GO:0016020;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;mitochondrial outer membrane#GO:0005741 secondary carrier transporter#PC00258;mitochondrial carrier protein#PC00158 HUMAN|HGNC=27936|UniProtKB=A6NES4 A6NES4 MROH2A PTHR23120:SF14 MAESTRO-RELATED HEAT DOMAIN-CONTAINING MAESTRO HEAT-LIKE REPEAT-CONTAINING PROTEIN FAMILY MEMBER 2A cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=12515|UniProtKB=P15374 P15374 UCHL3 PTHR10589:SF24 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L3 ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;cysteine-type deubiquitinase activity#GO:0004843;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005 macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;cellular process#GO:0009987;catabolic process#GO:0009056 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protease#PC00190;protein modifying enzyme#PC00260;cysteine protease#PC00081 HUMAN|HGNC=14056|UniProtKB=Q5T653 Q5T653 MRPL2 PTHR13691:SF73 RIBOSOMAL PROTEIN L2 LARGE RIBOSOMAL SUBUNIT PROTEIN UL2M structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 translation#GO:0006412;metabolic process#GO:0008152;mitochondrial gene expression#GO:0140053;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;mitochondrial translation#GO:0032543;cytoplasmic translation#GO:0002181 membrane-enclosed lumen#GO:0031974;cytosol#GO:0005829;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;mitochondrial large ribosomal subunit#GO:0005762;membraneless organelle#GO:0043228;ribosome#GO:0005840;mitochondrion#GO:0005739;organelle lumen#GO:0043233;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;mitochondrial ribosome#GO:0005761;intracellular anatomical structure#GO:0005622;organellar ribosome#GO:0000313;membrane-bounded organelle#GO:0043227 ribosomal protein#PC00202 HUMAN|HGNC=29562|UniProtKB=Q9Y4F3 Q9Y4F3 MARF1 PTHR14379:SF93 LIMKAIN B LKAP MEIOSIS REGULATOR AND MRNA STABILITY FACTOR 1 binding#GO:0005488;protein-containing complex binding#GO:0044877 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031 HUMAN|HGNC=20530|UniProtKB=P59991 P59991 KRTAP12-2 PTHR23262:SF180 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 12-1-RELATED structural protein#PC00211 HUMAN|HGNC=21622|UniProtKB=Q8TC20 Q8TC20 CAGE1 PTHR36864:SF1 CANCER-ASSOCIATED GENE 1 PROTEIN CANCER-ASSOCIATED GENE 1 PROTEIN HUMAN|HGNC=18803|UniProtKB=Q5TC12 Q5TC12 ATPAF1 PTHR13126:SF0 CHAPERONE ATP11 ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 1 cellular component assembly#GO:0022607;mitochondrial respiratory chain complex assembly#GO:0033108;mitochondrion organization#GO:0007005;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;mitochondrial proton-transporting ATP synthase complex assembly#GO:0033615 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739 chaperone#PC00072 HUMAN|HGNC=468|UniProtKB=P23109 P23109 AMPD1 PTHR11359:SF1 AMP DEAMINASE AMP DEAMINASE 1 catalytic activity#GO:0003824;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity#GO:0016787;deaminase activity#GO:0019239;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814 organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;carbohydrate derivative metabolic process#GO:1901135;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;nucleoside phosphate biosynthetic process#GO:1901293;primary metabolic process#GO:0044238;IMP metabolic process#GO:0046040;nucleoside monophosphate metabolic process#GO:0009123;nucleoside phosphate metabolic process#GO:0006753;organophosphate biosynthetic process#GO:0090407;IMP biosynthetic process#GO:0006188;ribose phosphate biosynthetic process#GO:0046390;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing compound biosynthetic process#GO:0034654;carbohydrate derivative biosynthetic process#GO:1901137;purine nucleoside monophosphate metabolic process#GO:0009126;nucleobase-containing small molecule metabolic process#GO:0055086;phosphorus metabolic process#GO:0006793;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;small molecule metabolic process#GO:0044281;purine ribonucleoside monophosphate metabolic process#GO:0009167;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;nucleoside monophosphate biosynthetic process#GO:0009124;ribonucleotide metabolic process#GO:0009259;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;nucleotide biosynthetic process#GO:0009165 deaminase#PC00088 HUMAN|HGNC=28474|UniProtKB=Q9BWS9 Q9BWS9 CHID1 PTHR46066:SF2 CHITINASE DOMAIN-CONTAINING PROTEIN 1 FAMILY MEMBER CHITINASE DOMAIN-CONTAINING PROTEIN 1 carbohydrate binding#GO:0030246;oligosaccharide binding#GO:0070492;binding#GO:0005488 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 HUMAN|HGNC=2765|UniProtKB=Q01524 Q01524 DEFA6 PTHR11876:SF3 ALPHA-DEFENSIN 1 DEFENSIN-6 response to external stimulus#GO:0009605;defense response#GO:0006952;antibacterial humoral response#GO:0019731;innate immune response#GO:0045087;antimicrobial humoral response#GO:0019730;humoral immune response#GO:0006959;response to other organism#GO:0051707;defense response to other organism#GO:0098542;immune response#GO:0006955;defense response to symbiont#GO:0140546;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;defense response to bacterium#GO:0042742;response to bacterium#GO:0009617;immune system process#GO:0002376;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;defense response to Gram-negative bacterium#GO:0050829;response to stimulus#GO:0050896;defense response to Gram-positive bacterium#GO:0050830 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 antimicrobial response protein#PC00051 HUMAN|HGNC=19016|UniProtKB=Q96DX7 Q96DX7 TRIM44 PTHR24103:SF597 E3 UBIQUITIN-PROTEIN LIGASE TRIM TRIPARTITE MOTIF-CONTAINING PROTEIN 44 catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659 defense response to symbiont#GO:0140546;regulation of protein stability#GO:0031647;immune response#GO:0006955;response to biotic stimulus#GO:0009607;regulation of macromolecule biosynthetic process#GO:0010556;response to stress#GO:0006950;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;response to other organism#GO:0051707;defense response to other organism#GO:0098542;response to external stimulus#GO:0009605;regulation of gene expression#GO:0010468;defense response#GO:0006952;protein stabilization#GO:0050821;regulation of biosynthetic process#GO:0009889;innate immune response#GO:0045087;regulation of biological process#GO:0050789;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;regulation of macromolecule metabolic process#GO:0060255;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;immune system process#GO:0002376;regulation of biological quality#GO:0065008 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=31955|UniProtKB=P0CB38 P0CB38 PABPC4L PTHR24012:SF776 RNA BINDING PROTEIN POLYADENYLATE-BINDING PROTEIN 4-LIKE RNA binding#GO:0003723;single-stranded RNA binding#GO:0003727;mRNA 3'-UTR binding#GO:0003730;nucleic acid binding#GO:0003676;binding#GO:0005488;poly(A) binding#GO:0008143;mRNA binding#GO:0003729 post-transcriptional regulation of gene expression#GO:0010608;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255 intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;nucleus#GO:0005634;cytosol#GO:0005829;cytoplasmic stress granule#GO:0010494;membraneless organelle#GO:0043228;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904 RNA metabolism protein#PC00031 HUMAN|HGNC=16873|UniProtKB=Q92562 Q92562 FIG4 PTHR45738:SF5 POLYPHOSPHOINOSITIDE PHOSPHATASE POLYPHOSPHOINOSITIDE PHOSPHATASE phosphatidylinositol-3,5-bisphosphate phosphatase activity#GO:0106018;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824 phospholipid dephosphorylation#GO:0046839;cellular process#GO:0009987;phosphate-containing compound metabolic process#GO:0006796;organophosphate metabolic process#GO:0019637;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phospholipid metabolic process#GO:0006644;glycerophospholipid metabolic process#GO:0006650;glycerolipid metabolic process#GO:0046486;phosphatidylinositol metabolic process#GO:0046488;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;phosphatidylinositol dephosphorylation#GO:0046856;dephosphorylation#GO:0016311;lipid modification#GO:0030258 intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 phosphatase#PC00181;hydrolase#PC00121 HUMAN|HGNC=32058|UniProtKB=Q6WRX3 Q6WRX3 ZYG11A PTHR12904:SF20 FAMILY NOT NAMED PROTEIN ZYG-11 HOMOLOG A Cul2-RING ubiquitin ligase complex#GO:0031462;transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151 HUMAN|HGNC=28359|UniProtKB=Q9H6F5 Q9H6F5 CCDC86 PTHR13557:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 86 COILED-COIL DOMAIN-CONTAINING PROTEIN 86 cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular organelle#GO:0043229 HUMAN|HGNC=24032|UniProtKB=Q5VVC0 Q5VVC0 SPO16 PTHR31408:SF2 HYPOTHETICAL PROTEIN LOC689986 PROTEIN SPO16 HOMOLOG chromosome organization#GO:0051276;meiotic chromosome segregation#GO:0045132;macromolecule metabolic process#GO:0043170;meiotic nuclear division#GO:0140013;nucleobase-containing compound metabolic process#GO:0006139;organelle fission#GO:0048285;sexual reproduction#GO:0019953;meiosis I cell cycle process#GO:0061982;homologous recombination#GO:0035825;reproductive process#GO:0022414;reciprocal homologous recombination#GO:0140527;cell cycle#GO:0007049;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;homologous chromosome segregation#GO:0045143;DNA recombination#GO:0006310;chromosome segregation#GO:0007059;chromosome organization involved in meiotic cell cycle#GO:0070192;metabolic process#GO:0008152;meiotic cell cycle#GO:0051321;DNA metabolic process#GO:0006259;homologous chromosome pairing at meiosis#GO:0007129;synaptonemal complex assembly#GO:0007130;cellular component assembly#GO:0022607;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;reciprocal meiotic recombination#GO:0007131;nuclear division#GO:0000280;cell cycle process#GO:0022402;meiosis I#GO:0007127;cellular component organization#GO:0016043;nuclear chromosome segregation#GO:0098813;meiotic cell cycle process#GO:1903046 chromosome#GO:0005694;intracellular organelle#GO:0043229;organelle#GO:0043226;membraneless organelle#GO:0043228;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=24688|UniProtKB=Q9BZK3 Q9BZK3 NACA4P PTHR21713:SF23 NASCENT POLYPEPTIDE ASSOCIATED COMPLEX ALPHA SUBUNIT-RELATED NASCENT POLYPEPTIDE-ASSOCIATED COMPLEX SUBUNIT ALPHA-LIKE PROTEIN-RELATED protein targeting to membrane#GO:0006612;localization within membrane#GO:0051668;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;establishment of protein localization to membrane#GO:0090150;cellular process#GO:0009987;establishment of protein localization#GO:0045184;protein targeting#GO:0006605 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=1548|UniProtKB=P16152 P16152 CBR1 PTHR43963:SF2 CARBONYL REDUCTASE 1-RELATED CARBONYL REDUCTASE [NADPH] 1 catalytic activity#GO:0003824;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;oxidoreductase activity#GO:0016491;alcohol dehydrogenase (NADP+) activity#GO:0008106;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614 oxidoreductase#PC00176;reductase#PC00198 HUMAN|HGNC=2243|UniProtKB=P61923 P61923 COPZ1 PTHR11043:SF2 ZETA-COAT PROTEIN COATOMER SUBUNIT ZETA-1 protein transport#GO:0015031;localization#GO:0051179;cellular localization#GO:0051641;intra-Golgi vesicle-mediated transport#GO:0006891;Golgi vesicle transport#GO:0048193;intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;establishment of protein localization#GO:0045184;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule localization#GO:0033036;vesicle-mediated transport#GO:0016192 membrane#GO:0016020;vesicle membrane#GO:0012506;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;COPI-coated vesicle#GO:0030137;cytoplasm#GO:0005737;vesicle coat#GO:0030120;Golgi apparatus#GO:0005794;Golgi-associated vesicle#GO:0005798;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;COPI vesicle coat#GO:0030126;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;coated vesicle membrane#GO:0030662;Golgi-associated vesicle membrane#GO:0030660;intracellular organelle#GO:0043229;membrane coat#GO:0030117;coated membrane#GO:0048475;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;coated vesicle#GO:0030135;membrane-bounded organelle#GO:0043227 membrane traffic protein#PC00150;vesicle coat protein#PC00235 HUMAN|HGNC=30942|UniProtKB=A0A096LP49 A0A096LP49 CCDC187 PTHR13958:SF5 CENTROSOME-ASSOCIATED PROTEIN 350 COILED-COIL DOMAIN-CONTAINING PROTEIN 187 microtubule or microtubule-binding cytoskeletal protein#PC00157;non-motor microtubule binding protein#PC00166 HUMAN|HGNC=9559|UniProtKB=Q13200 Q13200 PSMD2 PTHR10943:SF11 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498 catalytic complex#GO:1902494;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endopeptidase complex#GO:1905369;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;proteasome complex#GO:0000502;nucleus#GO:0005634;peptidase complex#GO:1905368;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;protein-containing complex#GO:0032991 protease#PC00190 Ubiquitin proteasome pathway#P00060>26S proteasome#P01489 HUMAN|HGNC=2280|UniProtKB=P14854 P14854 COX6B1 PTHR11387:SF16 CYTOCHROME C OXIDASE SUBUNIT 6B CYTOCHROME C OXIDASE SUBUNIT 6B1 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;membrane protein complex#GO:0098796;cytochrome complex#GO:0070069;mitochondrion#GO:0005739;respiratory chain complex IV#GO:0045277;transmembrane transporter complex#GO:1902495;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;oxidoreductase complex#GO:1990204;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;respiratory chain complex#GO:0098803;transporter complex#GO:1990351;organelle membrane#GO:0031090 oxidoreductase#PC00176;oxidase#PC00175 HUMAN|HGNC=14870|UniProtKB=Q9BWW8 Q9BWW8 APOL6 PTHR14096:SF7 APOLIPOPROTEIN L APOLIPOPROTEIN L6 binding#GO:0005488;lipid binding#GO:0008289 cellular anatomical structure#GO:0110165;membrane#GO:0016020 apolipoprotein#PC00052;transfer/carrier protein#PC00219 HUMAN|HGNC=7064|UniProtKB=O14880 O14880 MGST3 PTHR10250:SF26 MICROSOMAL GLUTATHIONE S-TRANSFERASE GLUTATHIONE S-TRANSFERASE 3, MITOCHONDRIAL glutathione transferase activity#GO:0004364;oxidoreductase activity, acting on peroxide as acceptor#GO:0016684;peroxidase activity#GO:0004601;antioxidant activity#GO:0016209;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;oxidoreductase activity#GO:0016491 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nuclear envelope#GO:0005635;organelle envelope#GO:0031967;nucleus#GO:0005634 transferase#PC00220 HUMAN|HGNC=25204|UniProtKB=Q2NL68 Q2NL68 PROSER3 PTHR22045:SF6 PROLINE AND SERINE-RICH PROTEIN 3 PROLINE AND SERINE-RICH PROTEIN 3 HUMAN|HGNC=5648|UniProtKB=P0DP06 P0DP06 IGHV4-30-4 PTHR23266:SF323 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 4-30-2-RELATED antigen binding#GO:0003823;binding#GO:0005488 response to stimulus#GO:0050896;adaptive immune response#GO:0002250;immune response#GO:0006955;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;immunoglobulin mediated immune response#GO:0016064;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immune system process#GO:0002376;immune effector process#GO:0002252 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=24128|UniProtKB=Q9BRN9 Q9BRN9 TM2D3 PTHR21016:SF7 BETA-AMYLOID BINDING PROTEIN-RELATED TM2 DOMAIN-CONTAINING PROTEIN 3 signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 regulation of response to stimulus#GO:0048583;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of response to stimulus#GO:0048584;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of signaling#GO:0023056;cell communication#GO:0007154;regulation of Notch signaling pathway#GO:0008593;regulation of signaling#GO:0023051;regulation of cell communication#GO:0010646;signaling#GO:0023052;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;positive regulation of Notch signaling pathway#GO:0045747;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967 HUMAN|HGNC=30237|UniProtKB=Q6P1N0 Q6P1N0 CC2D1A PTHR13076:SF8 COILED-COIL AND C2 DOMAIN-CONTAINING PROTEIN 1-LIKE COILED-COIL AND C2 DOMAIN-CONTAINING PROTEIN 1A RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=29556|UniProtKB=Q9BUP0 Q9BUP0 EFHD1 PTHR13025:SF5 EF-HAND DOMAIN-CONTAINING PROTEIN D EF-HAND DOMAIN-CONTAINING PROTEIN D1 molecular function regulator activity#GO:0098772;molecular sensor activity#GO:0140299;cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094 organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622 calmodulin-related#PC00061 HUMAN|HGNC=29658|UniProtKB=Q9BRJ9 Q9BRJ9 MESP1 PTHR20937:SF6 IP14615P MESODERM POSTERIOR PROTEIN 1 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 formation of primary germ layer#GO:0001704;animal gross anatomical part developmental process#GO:0160108;chordate embryonic development#GO:0043009;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;gastrulation#GO:0007369;regulation of transcription by RNA polymerase II#GO:0006357;circulatory system development#GO:0072359;anterior/posterior pattern specification#GO:0009952;anatomical structure formation involved in morphogenesis#GO:0048646;mesoderm development#GO:0007498;animal organ development#GO:0048513;anterior/posterior axis specification#GO:0009948;embryonic morphogenesis#GO:0048598;multicellular organism development#GO:0007275;embryonic pattern specification#GO:0009880;embryo development#GO:0009790;heart development#GO:0007507;embryo development ending in birth or egg hatching#GO:0009792;pattern specification process#GO:0007389;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;tissue morphogenesis#GO:0048729;mesoderm morphogenesis#GO:0048332;heart morphogenesis#GO:0003007;regulation of cellular process#GO:0050794;animal organ morphogenesis#GO:0009887;regulation of macromolecule metabolic process#GO:0060255;developmental process#GO:0032502;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;tissue development#GO:0009888;regionalization#GO:0003002;mesoderm formation#GO:0001707;epithelium development#GO:0060429;regulation of nucleobase-containing compound metabolic process#GO:0019219 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=6726|UniProtKB=Q99467 Q99467 CD180 PTHR24373:SF356 SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN CD180 ANTIGEN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=8657|UniProtKB=Q9NPG4 Q9NPG4 PCDH12 PTHR24028:SF42 CADHERIN-87A PROTOCADHERIN-12 cell-cell adhesion#GO:0098609;cellular process#GO:0009987;cell adhesion#GO:0007155 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 cadherin#PC00057;cell adhesion molecule#PC00069 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HUMAN|HGNC=15111|UniProtKB=Q8NGR9 Q8NGR9 OR1N2 PTHR48001:SF135 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 1N2 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cell communication#GO:0007154 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=328|UniProtKB=O95994 O95994 AGR2 PTHR15337:SF1 ANTERIOR GRADIENT PROTEIN-RELATED ANTERIOR GRADIENT PROTEIN 2 HOMOLOG response to stimulus#GO:0050896;defense response#GO:0006952;response to stress#GO:0006950;inflammatory response#GO:0006954 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 reductase#PC00198;oxidoreductase#PC00176 HUMAN|HGNC=13098|UniProtKB=Q8IZ26 Q8IZ26 ZNF34 PTHR24377:SF818 IP01015P-RELATED ZINC FINGER PROTEIN 34 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=33824|UniProtKB=P0DPF6 P0DPF6 CDRT15P3 PTHR16471:SF2 CMT1A DUPLICATED REGION TRANSCRIPT 15 PROTEIN-LIKE PROTEIN SUBFAMILY NOT NAMED HUMAN|HGNC=28739|UniProtKB=Q8IXQ9 Q8IXQ9 ETFBKMT PTHR43648:SF3 ELECTRON TRANSFER FLAVOPROTEIN BETA SUBUNIT LYSINE METHYLTRANSFERASE ELECTRON TRANSFER FLAVOPROTEIN BETA SUBUNIT LYSINE METHYLTRANSFERASE catalytic activity, acting on a protein#GO:0140096;protein methyltransferase activity#GO:0008276;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity#GO:0003824;transferase activity#GO:0016740;lysine N-methyltransferase activity#GO:0016278;N-methyltransferase activity#GO:0008170;protein-lysine N-methyltransferase activity#GO:0016279;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168 regulation of catabolic process#GO:0009894;negative regulation of catabolic process#GO:0009895;negative regulation of cellular process#GO:0048523;regulation of lipid metabolic process#GO:0019216;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of lipid catabolic process#GO:0050994 methyltransferase#PC00155 HUMAN|HGNC=6851|UniProtKB=Q12852 Q12852 MAP3K12 PTHR44329:SF17 SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 12 phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;JNK cascade#GO:0007254;signaling#GO:0023052;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;MAPK cascade#GO:0000165;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Gonadotropin-releasing hormone receptor pathway#P06664>MAP3Ks#P06834 HUMAN|HGNC=7220|UniProtKB=Q14168 Q14168 MPP2 PTHR23122:SF35 MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK MAGUK P55 SUBFAMILY MEMBER 2 membrane#GO:0016020;cell-cell junction#GO:0005911;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;cell junction#GO:0030054;anchoring junction#GO:0070161;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HUMAN|HGNC=14326|UniProtKB=Q9BXJ4 Q9BXJ4 C1QTNF3 PTHR22923:SF115 CEREBELLIN-RELATED COMPLEMENT C1Q TUMOR NECROSIS FACTOR-RELATED PROTEIN 3 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=9525|UniProtKB=Q9UQ74 Q9UQ74 PSG8 PTHR44427:SF3 CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 19 PREGNANCY-SPECIFIC BETA-1-GLYCOPROTEIN 8 cell adhesion molecule#PC00069 HUMAN|HGNC=2365|UniProtKB=Q14194 Q14194 CRMP1 PTHR11647:SF54 HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER DIHYDROPYRIMIDINASE-RELATED PROTEIN 1 hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;dihydropyrimidinase activity#GO:0004157;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides#GO:0016812;catalytic activity#GO:0003824 nucleobase catabolic process#GO:0046113;nucleobase-containing compound metabolic process#GO:0006139;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;pyrimidine-containing compound metabolic process#GO:0072527;cellular process#GO:0009987;pyrimidine nucleobase catabolic process#GO:0006208;primary metabolic process#GO:0044238;nucleobase metabolic process#GO:0009112;nucleobase-containing small molecule metabolic process#GO:0055086;pyrimidine nucleobase metabolic process#GO:0006206;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 hydrolase#PC00121 Axon guidance mediated by semaphorins#P00007>CRMP#P00339 HUMAN|HGNC=2908|UniProtKB=O00548 O00548 DLL1 PTHR24044:SF380 NOTCH LIGAND FAMILY MEMBER DELTA-LIKE PROTEIN 1 protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;negative regulation of biological process#GO:0048519;signaling#GO:0023052;regulation of cell communication#GO:0010646;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of signaling#GO:0023051;regulation of Notch signaling pathway#GO:0008593;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648;cell communication#GO:0007154;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;negative regulation of response to stimulus#GO:0048585;negative regulation of Notch signaling pathway#GO:0045746;cell surface receptor signaling pathway#GO:0007166;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;Notch signaling pathway#GO:0007219 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 Notch signaling pathway#P00045>Delta#P01116;Angiogenesis#P00005>Delta/Serrate#P00226 HUMAN|HGNC=17795|UniProtKB=Q9H4B6 Q9H4B6 SAV1 PTHR47522:SF2 SALVADOR FAMILY WW DOMAIN-CONTAINING PROTEIN 1 PROTEIN SALVADOR HOMOLOG 1 negative regulation of cell population proliferation#GO:0008285;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;hippo signaling#GO:0035329;negative regulation of cellular process#GO:0048523;regulation of apoptotic process#GO:0042981;positive regulation of apoptotic process#GO:0043065;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;positive regulation of programmed cell death#GO:0043068;regulation of cellular process#GO:0050794;signaling#GO:0023052;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;intracellular signal transduction#GO:0035556 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 HUMAN|HGNC=11553|UniProtKB=Q01995 Q01995 TAGLN PTHR47385:SF16 CALPONIN TRANSGELIN actin binding#GO:0003779;actin filament binding#GO:0051015;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 actin filament-based process#GO:0030029;cellular component organization or biogenesis#GO:0071840;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;actin cytoskeleton organization#GO:0030036;cytoskeleton organization#GO:0007010 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;actin cytoskeleton#GO:0015629 HUMAN|HGNC=29170|UniProtKB=Q9Y2M0 Q9Y2M0 FAN1 PTHR15749:SF4 FANCONI-ASSOCIATED NUCLEASE 1 FANCONI-ASSOCIATED NUCLEASE 1 HUMAN|HGNC=8845|UniProtKB=O15534 O15534 PER1 PTHR11269:SF8 PERIOD CIRCADIAN PROTEIN PERIOD CIRCADIAN PROTEIN HOMOLOG 1 transcription factor binding#GO:0008134;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;protein binding#GO:0005515 biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;response to radiation#GO:0009314;negative regulation of macromolecule metabolic process#GO:0010605;regulation of circadian rhythm#GO:0042752;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;response to external stimulus#GO:0009605;regulation of biosynthetic process#GO:0009889;photoperiodism#GO:0009648;negative regulation of cellular process#GO:0048523;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;response to light stimulus#GO:0009416;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of DNA-templated transcription#GO:0006355;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;circadian regulation of gene expression#GO:0032922;response to abiotic stimulus#GO:0009628;negative regulation of biological process#GO:0048519;circadian rhythm#GO:0007623;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;rhythmic process#GO:0048511 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 transcription cofactor#PC00217 Gonadotropin-releasing hormone receptor pathway#P06664>mPer1#G06895;Gonadotropin-releasing hormone receptor pathway#P06664>mPer1#G06681;Circadian clock system#P00015>Per#P00504;Circadian clock system#P00015>per#G01503;Circadian clock system#P00015>per#G01499 HUMAN|HGNC=12390|UniProtKB=Q13630 Q13630 GFUS PTHR43238:SF1 GDP-L-FUCOSE SYNTHASE GDP-L-FUCOSE SYNTHASE oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824 oxidoreductase#PC00176 HUMAN|HGNC=13706|UniProtKB=Q9P2T0 Q9P2T0 SPMAP2 PTHR15901:SF16 TESTICULAR HAPLOID EXPRESSED GENE PROTEIN SPERM MICROTUBULE ASSOCIATED PROTEIN 2 developmental process#GO:0032502;sexual reproduction#GO:0019953;spermatogenesis#GO:0007283;multicellular organismal reproductive process#GO:0048609;developmental process involved in reproduction#GO:0003006;male gamete generation#GO:0048232;gamete generation#GO:0007276;reproductive process#GO:0022414 HUMAN|HGNC=26108|UniProtKB=Q8N3C7 Q8N3C7 CLIP4 PTHR18916:SF32 DYNACTIN 1-RELATED MICROTUBULE-BINDING CAP-GLY DOMAIN-CONTAINING LINKER PROTEIN 4 microtubule binding#GO:0008017;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;protein binding#GO:0005515 organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;cytoplasmic microtubule organization#GO:0031122;cytoskeleton organization#GO:0007010;cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226;supramolecular fiber organization#GO:0097435;microtubule-based process#GO:0007017 microtubule end#GO:1990752;cell cortex#GO:0005938;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;supramolecular fiber#GO:0099512;microtubule#GO:0005874;nucleus#GO:0005634;cell periphery#GO:0071944;microtubule cytoskeleton#GO:0015630;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;microtubule plus-end#GO:0035371 chaperone#PC00072 HUMAN|HGNC=28998|UniProtKB=Q92564 Q92564 DCUN1D4 PTHR12281:SF8 RP42 RELATED DCN1-LIKE PROTEIN 4 ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;binding#GO:0005488;protein binding#GO:0005515;transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 positive regulation of protein metabolic process#GO:0051247;regulation of post-translational protein modification#GO:1901873;positive regulation of metabolic process#GO:0009893;regulation of protein modification process#GO:0031399;regulation of protein metabolic process#GO:0051246;regulation of protein modification by small protein conjugation or removal#GO:1903320;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789;positive regulation of cellular process#GO:0048522;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of macromolecule metabolic process#GO:0010604;biological regulation#GO:0065007 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=4993|UniProtKB=B2RPK0 B2RPK0 HMGB1P1 PTHR48112:SF39 HIGH MOBILITY GROUP PROTEIN DSP1 HIGH MOBILITY GROUP PROTEIN B1-LIKE 1 cellular process#GO:0009987;cellular component organization#GO:0016043;chromatin organization#GO:0006325;chromatin remodeling#GO:0006338;cellular component organization or biogenesis#GO:0071840 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 HMG box transcription factor#PC00024;gene-specific transcriptional regulator#PC00264 p53 pathway#P00059>HMG1#P04619 HUMAN|HGNC=28343|UniProtKB=Q8TCB7 Q8TCB7 METTL6 PTHR22809:SF5 METHYLTRANSFERASE-RELATED TRNA N(3)-CYTIDINE METHYLTRANSFERASE METTL6 methyltransferase#PC00155 HUMAN|HGNC=5045|UniProtKB=P14866 P14866 HNRNPL PTHR15592:SF20 MATRIN 3/NUCLEAR PROTEIN 220-RELATED HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN L RNA processing factor#PC00147 HUMAN|HGNC=8465|UniProtKB=Q8NGA0 Q8NGA0 OR7G1 PTHR48001:SF67 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 7G1 transmembrane signal receptor#PC00197 HUMAN|HGNC=8959|UniProtKB=Q92521 Q92521 PIGB PTHR22760:SF4 GLYCOSYLTRANSFERASE GPI ALPHA-1,2-MANNOSYLTRANSFERASE 3 glycosyltransferase activity#GO:0016757;mannosyltransferase activity#GO:0000030;transferase activity#GO:0016740;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 organophosphate biosynthetic process#GO:0090407;protein metabolic process#GO:0019538;glycolipid biosynthetic process#GO:0009247;phospholipid metabolic process#GO:0006644;glycolipid metabolic process#GO:0006664;phospholipid biosynthetic process#GO:0008654;GPI anchored protein biosynthesis#GO:0180046;glycerolipid metabolic process#GO:0046486;liposaccharide metabolic process#GO:1903509;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;lipid metabolic process#GO:0006629;GPI anchor metabolic process#GO:0006505;glycerophospholipid biosynthetic process#GO:0046474;metabolic process#GO:0008152;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604;lipid biosynthetic process#GO:0008610;glycerophospholipid metabolic process#GO:0006650;GPI anchor biosynthetic process#GO:0006506;glycerolipid biosynthetic process#GO:0045017;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;organophosphate metabolic process#GO:0019637 membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227 glycosyltransferase#PC00111 HUMAN|HGNC=24254|UniProtKB=Q96CN7 Q96CN7 ISOC1 PTHR14119:SF17 HYDROLASE ISOCHORISMATASE DOMAIN-CONTAINING PROTEIN 1 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HUMAN|HGNC=418|UniProtKB=P09972 P09972 ALDOC PTHR11627:SF3 FRUCTOSE-BISPHOSPHATE ALDOLASE FRUCTOSE-BISPHOSPHATE ALDOLASE C aldehyde-lyase activity#GO:0016832;fructose-bisphosphate aldolase activity#GO:0004332;lyase activity#GO:0016829;carbon-carbon lyase activity#GO:0016830;catalytic activity#GO:0003824 nucleobase-containing compound metabolic process#GO:0006139;organophosphate metabolic process#GO:0019637;nucleobase-containing compound catabolic process#GO:0034655;carbohydrate derivative metabolic process#GO:1901135;ribonucleotide catabolic process#GO:0009261;glycolytic process#GO:0006096;purine ribonucleoside triphosphate metabolic process#GO:0009205;ADP metabolic process#GO:0046031;energy derivation by oxidation of organic compounds#GO:0015980;nucleotide catabolic process#GO:0009166;generation of precursor metabolites and energy#GO:0006091;purine ribonucleoside diphosphate metabolic process#GO:0009179;catabolic process#GO:0009056;nucleoside phosphate catabolic process#GO:1901292;carbohydrate metabolic process#GO:0005975;nucleoside phosphate metabolic process#GO:0006753;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate derivative catabolic process#GO:1901136;primary metabolic process#GO:0044238;purine ribonucleotide catabolic process#GO:0009154;nucleoside diphosphate catabolic process#GO:0009134;purine nucleoside triphosphate metabolic process#GO:0009144;organophosphate catabolic process#GO:0046434;ribonucleoside diphosphate catabolic process#GO:0009191;cellular respiration#GO:0045333;purine ribonucleoside diphosphate catabolic process#GO:0009181;aerobic respiration#GO:0009060;nucleoside diphosphate metabolic process#GO:0009132;purine nucleotide catabolic process#GO:0006195;pyridine-containing compound metabolic process#GO:0072524;nicotinamide nucleotide metabolic process#GO:0046496;ATP metabolic process#GO:0046034;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;purine-containing compound catabolic process#GO:0072523;nucleobase-containing small molecule metabolic process#GO:0055086;purine nucleoside diphosphate catabolic process#GO:0009137;metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;ADP catabolic process#GO:0046032;small molecule metabolic process#GO:0044281;pyridine nucleotide catabolic process#GO:0019364;pyruvate metabolic process#GO:0006090;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;phosphorus metabolic process#GO:0006793;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;ribonucleoside diphosphate metabolic process#GO:0009185;pyridine-containing compound catabolic process#GO:0072526;nucleotide metabolic process#GO:0009117;carbohydrate catabolic process#GO:0016052;oxoacid metabolic process#GO:0043436;ribonucleotide metabolic process#GO:0009259;purine nucleoside diphosphate metabolic process#GO:0009135 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 aldolase#PC00044;lyase#PC00144 Fructose galactose metabolism#P02744>Fructose bisphosphate aldolase#P02959;Glycolysis#P00024>Aldolase#P00679 HUMAN|HGNC=4384|UniProtKB=P63096 P63096 GNAI1 PTHR10218:SF359 GTP-BINDING PROTEIN ALPHA SUBUNIT GUANINE NUCLEOTIDE-BINDING PROTEIN G(I) SUBUNIT ALPHA-1 hydrolase activity, acting on acid anhydrides#GO:0016817;G protein-coupled receptor binding#GO:0001664;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;molecular function regulator activity#GO:0098772;ribonucleoside triphosphate phosphatase activity#GO:0017111;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;signaling receptor binding#GO:0005102;hydrolase activity#GO:0016787;protein binding#GO:0005515 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cell communication#GO:0007154 cytoplasmic side of membrane#GO:0098562;extrinsic component of plasma membrane#GO:0019897;extrinsic component of membrane#GO:0019898;membrane#GO:0016020;cell periphery#GO:0071944;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;plasma membrane#GO:0005886;extrinsic component of cytoplasmic side of plasma membrane#GO:0031234;catalytic complex#GO:1902494;side of membrane#GO:0098552;intracellular anatomical structure#GO:0005622;cytoplasmic side of plasma membrane#GO:0009898;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cellular anatomical structure#GO:0110165 G-protein#PC00020;heterotrimeric G-protein#PC00117 PI3 kinase pathway#P00048>Galpha#P01199;Enkephalin release#P05913>G-Protein (i)#P05974;Gonadotropin-releasing hormone receptor pathway#P06664>gnai#P06807;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>G-Protein#P01085;Opioid proopiomelanocortin pathway#P05917>G-protein#P06012;Metabotropic glutamate receptor group III pathway#P00039>G-Protein#P01045;Nicotine pharmacodynamics pathway#P06587>GNAI#P06609;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Galphai#P00828;GABA-B receptor II signaling#P05731>Gi/oalpha#P05757;Metabotropic glutamate receptor group II pathway#P00040>G-protein#P01047;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Gialpha#P00712;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Galphai/q#P00873;Dopamine receptor mediated signaling pathway#P05912>Gialpha#P05958;Opioid prodynorphin pathway#P05916>G-protein#P06002;5HT1 type receptor mediated signaling pathway#P04373>G-protein#P04408;Opioid proenkephalin pathway#P05915>G-protein#P05994;Gonadotropin-releasing hormone receptor pathway#P06664>gnai/o#P06773;Endogenous cannabinoid signaling#P05730>Galpha#P05751 HUMAN|HGNC=15797|UniProtKB=Q4VXU2 Q4VXU2 PABPC1L PTHR24012:SF933 RNA BINDING PROTEIN POLYADENYLATE-BINDING PROTEIN 1-LIKE RNA binding#GO:0003723;mRNA 3'-UTR binding#GO:0003730;single-stranded RNA binding#GO:0003727;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488;poly(A) binding#GO:0008143 cellular process involved in reproduction in multicellular organism#GO:0022412;cell development#GO:0048468;reproductive process#GO:0022414;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;gamete generation#GO:0007276;regulation of biological process#GO:0050789;anatomical structure maturation#GO:0071695;germ cell development#GO:0007281;developmental process involved in reproduction#GO:0003006;multicellular organismal reproductive process#GO:0048609;anatomical structure development#GO:0048856;sexual reproduction#GO:0019953;biological regulation#GO:0065007;oogenesis#GO:0048477;developmental maturation#GO:0021700;cellular process#GO:0009987;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;cell maturation#GO:0048469;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;developmental process#GO:0032502;post-transcriptional regulation of gene expression#GO:0010608 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;cytoplasmic stress granule#GO:0010494;membraneless organelle#GO:0043228;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;protein-containing complex#GO:0032991;nucleus#GO:0005634;cytosol#GO:0005829 RNA metabolism protein#PC00031 HUMAN|HGNC=7451|UniProtKB=Q13615 Q13615 MTMR3 PTHR10807:SF66 MYOTUBULARIN-RELATED PHOSPHATIDYLINOSITOL-3,5-BISPHOSPHATE 3-PHOSPHATASE MTMR3 hydrolase activity#GO:0016787;protein binding#GO:0005515;phosphatase binding#GO:0019902;binding#GO:0005488;enzyme binding#GO:0019899;phosphoric ester hydrolase activity#GO:0042578;phosphatidylinositol-3,5-bisphosphate phosphatase activity#GO:0106018;protein phosphatase binding#GO:0019903;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791 phospholipid metabolic process#GO:0006644;glycerophospholipid metabolic process#GO:0006650;glycerolipid metabolic process#GO:0046486;phosphate-containing compound metabolic process#GO:0006796;cellular process#GO:0009987;phospholipid dephosphorylation#GO:0046839;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;organophosphate metabolic process#GO:0019637;dephosphorylation#GO:0016311;lipid modification#GO:0030258;phosphatidylinositol metabolic process#GO:0046488;lipid metabolic process#GO:0006629;phosphatidylinositol dephosphorylation#GO:0046856;metabolic process#GO:0008152 membrane#GO:0016020;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 phosphatase#PC00181 HUMAN|HGNC=12196|UniProtKB=A0A075B6N2 A0A075B6N2 TRBV20-1 PTHR23268:SF130 T-CELL RECEPTOR BETA CHAIN T CELL RECEPTOR BETA VARIABLE 20-1 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=24080|UniProtKB=Q8WW43 Q8WW43 APH1B PTHR12889:SF1 GAMMA-SECRETASE SUBUNIT APH-1 GAMMA-SECRETASE SUBUNIT APH-1B molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 biosynthetic process#GO:0009058;biological regulation#GO:0065007;gene expression#GO:0010467;protein maturation#GO:0051604;macromolecule biosynthetic process#GO:0009059;protein processing#GO:0016485;cellular process#GO:0009987;signal transduction#GO:0007165;Notch signaling pathway#GO:0007219;macromolecule metabolic process#GO:0043170;cell surface receptor signaling pathway#GO:0007166;metabolic process#GO:0008152;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;cell communication#GO:0007154;proteolysis#GO:0006508 catalytic complex#GO:1902494;membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 protease#PC00190;protein modifying enzyme#PC00260 Alzheimer disease-amyloid secretase pathway#P00003>Aph-1#P00091;Notch signaling pathway#P00045>Aph-1#P01109;Alzheimer disease-presenilin pathway#P00004>Aph-1#P00170 HUMAN|HGNC=11094|UniProtKB=O43623 O43623 SNAI2 PTHR24388:SF42 ZINC FINGER PROTEIN ZINC FINGER PROTEIN SNAI2 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=18140|UniProtKB=Q9UBD6 Q9UBD6 RHCG PTHR11730:SF30 AMMONIUM TRANSPORTER AMMONIUM TRANSPORTER RH TYPE C passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;channel activity#GO:0015267 transport#GO:0006810;inorganic ion homeostasis#GO:0098771;chemical homeostasis#GO:0048878;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;nitrogen compound transport#GO:0071705;cellular process#GO:0009987;homeostatic process#GO:0042592 apical part of cell#GO:0045177;cell periphery#GO:0071944;basal plasma membrane#GO:0009925;membrane#GO:0016020;apical plasma membrane#GO:0016324;basal part of cell#GO:0045178;basolateral plasma membrane#GO:0016323;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590 transporter#PC00227;primary active transporter#PC00068 HUMAN|HGNC=2973|UniProtKB=O00429 O00429 DNM1L PTHR11566:SF39 DYNAMIN DYNAMIN-1-LIKE PROTEIN ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;cytoskeletal protein binding#GO:0008092;hydrolase activity, acting on acid anhydrides#GO:0016817;tubulin binding#GO:0015631;hydrolase activity#GO:0016787;protein binding#GO:0005515;microtubule binding#GO:0008017;GTPase activity#GO:0003924;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818 localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;organelle fission#GO:0048285;mitochondrion localization#GO:0051646;organelle localization#GO:0051640;peroxisome organization#GO:0007031;mitochondrial fission#GO:0000266;mitochondrion organization#GO:0007005;apoptotic mitochondrial changes#GO:0008637;organelle organization#GO:0006996;cellular component organization#GO:0016043;programmed cell death#GO:0012501;cell death#GO:0008219;apoptotic process#GO:0006915;cellular process#GO:0009987 microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cytoskeleton#GO:0005856;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;membrane#GO:0016020;microtubule cytoskeleton#GO:0015630 membrane traffic protein#PC00150 HUMAN|HGNC=7842|UniProtKB=P08949 P08949 NMB PTHR16866:SF5 GASTRIN-RELEASING PEPTIDE NEUROMEDIN-B protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102;neuropeptide receptor binding#GO:0071855;G protein-coupled receptor binding#GO:0001664 regulation of localization#GO:0032879;response to external stimulus#GO:0009605;regulation of transport#GO:0051049;biological regulation#GO:0065007;positive regulation of cellular process#GO:0048522;positive regulation of secretion by cell#GO:1903532;positive regulation of transport#GO:0051050;positive regulation of biological process#GO:0048518;positive regulation of signaling#GO:0023056;regulation of hormone secretion#GO:0046883;regulation of secretion#GO:0051046;regulation of biological quality#GO:0065008;regulation of secretion by cell#GO:1903530;regulation of signaling#GO:0023051;positive regulation of secretion#GO:0051047;positive regulation of hormone secretion#GO:0046887;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of cell communication#GO:0010646;regulation of hormone levels#GO:0010817;regulation of biological process#GO:0050789 HUMAN|HGNC=19157|UniProtKB=Q8NEV9 Q8NEV9 IL27 PTHR20879:SF1 INTERLEUKIN-27 SUBUNIT ALPHA INTERLEUKIN-27 SUBUNIT ALPHA signaling receptor binding#GO:0005102;binding#GO:0005488;cytokine receptor binding#GO:0005126;protein binding#GO:0005515 regulation of immune response#GO:0050776;regulation of immune effector process#GO:0002697;regulation of cell population proliferation#GO:0042127;regulation of hemopoiesis#GO:1903706;regulation of multicellular organismal development#GO:2000026;regulation of cell activation#GO:0050865;regulation of biological process#GO:0050789;regulation of leukocyte activation#GO:0002694;regulation of lymphocyte activation#GO:0051249;regulation of developmental process#GO:0050793;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of T cell proliferation#GO:0042129;regulation of cell differentiation#GO:0045595;regulation of response to stimulus#GO:0048583;regulation of leukocyte proliferation#GO:0070663;regulation of cell development#GO:0060284;regulation of mononuclear cell proliferation#GO:0032944;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;regulation of T cell activation#GO:0050863;regulation of lymphocyte proliferation#GO:0050670 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 interleukin superfamily#PC00128;intercellular signal molecule#PC00207 HUMAN|HGNC=1034|UniProtKB=Q14457 Q14457 BECN1 PTHR12768:SF6 BECLIN 1 BECLIN-1 phosphatidylinositol 3-kinase binding#GO:0043548;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;protein binding#GO:0005515 cellular component organization#GO:0016043;late endosome to vacuole transport#GO:0045324;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;process utilizing autophagic mechanism#GO:0061919;cellular localization#GO:0051641;autophagosome organization#GO:1905037;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;autophagy#GO:0006914;response to stress#GO:0006950;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;vesicle-mediated transport#GO:0016192;cellular component assembly#GO:0022607;metabolic process#GO:0008152;autophagosome assembly#GO:0000045;cellular component organization or biogenesis#GO:0071840;cellular response to stimulus#GO:0051716;response to starvation#GO:0042594;catabolic process#GO:0009056;organelle assembly#GO:0070925;vacuole organization#GO:0007033;localization#GO:0051179;response to nutrient levels#GO:0031667;macroautophagy#GO:0016236;transport#GO:0006810;cellular response to nutrient levels#GO:0031669;vacuolar transport#GO:0007034;autophagy of mitochondrion#GO:0000422;intracellular transport#GO:0046907;cellular response to starvation#GO:0009267;establishment of localization#GO:0051234;mitophagy#GO:0000423 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;membrane#GO:0016020;membrane protein complex#GO:0098796;intracellular anatomical structure#GO:0005622;extrinsic component of membrane#GO:0019898;phosphatidylinositol 3-kinase complex, class III#GO:0035032;phagophore assembly site#GO:0000407;catalytic complex#GO:1902494;transferase complex#GO:1990234;transferase complex, transferring phosphorus-containing groups#GO:0061695 protease inhibitor#PC00191 HUMAN|HGNC=9549|UniProtKB=P17980 P17980 PSMC3 PTHR23073:SF90 26S PROTEASOME REGULATORY SUBUNIT 26S PROTEASOME REGULATORY SUBUNIT 6A isomerase activity#GO:0016853;catalytic activity#GO:0003824;polypeptide conformation or assembly isomerase activity#GO:0120544;macromolecular conformation isomerase activity#GO:0120543;ATP-dependent activity#GO:0140657 modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;peptidase complex#GO:1905368;proteasome complex#GO:0000502;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;catalytic complex#GO:1902494;endopeptidase complex#GO:1905369 protease#PC00190 HUMAN|HGNC=19683|UniProtKB=Q8TAS1 Q8TAS1 UHMK1 PTHR46962:SF1 SERINE/THREONINE-PROTEIN KINASE KIST SERINE_THREONINE-PROTEIN KINASE KIST kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;binding#GO:0005488;protein kinase activity#GO:0004672;protein-containing complex binding#GO:0044877;ribonucleoprotein complex binding#GO:0043021;phosphotransferase activity, alcohol group as acceptor#GO:0016773 regulation of cellular process#GO:0050794;regulation of protein transport#GO:0051223;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;regulation of establishment of protein localization#GO:0070201;positive regulation of translation#GO:0045727;regulation of protein localization#GO:0032880;positive regulation of protein metabolic process#GO:0051247;regulation of translational initiation#GO:0006446;positive regulation of macromolecule metabolic process#GO:0010604;biological regulation#GO:0065007;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of localization#GO:0032879;regulation of transport#GO:0051049;positive regulation of gene expression#GO:0010628;post-transcriptional regulation of gene expression#GO:0010608 membraneless organelle#GO:0043228;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;neuron projection#GO:0043005;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cell projection#GO:0042995;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;neuron projection cytoplasm#GO:0120111 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=1730|UniProtKB=Q9UQ88 Q9UQ88 CDK11A PTHR24056:SF599 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE 11A-RELATED protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740 regulation of biological process#GO:0050789;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of mRNA processing#GO:0050684;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of mRNA metabolic process#GO:1903311 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=21526|UniProtKB=Q8TDQ7 Q8TDQ7 GNPDA2 PTHR11280:SF9 GLUCOSAMINE-6-PHOSPHATE ISOMERASE GLUCOSAMINE-6-PHOSPHATE DEAMINASE 2 identical protein binding#GO:0042802;deaminase activity#GO:0019239;protein binding#GO:0005515;hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;catalytic activity#GO:0003824;binding#GO:0005488 oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;amino sugar catabolic process#GO:0046348;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;carbohydrate derivative metabolic process#GO:1901135;carboxylic acid metabolic process#GO:0019752;small molecule catabolic process#GO:0044282;carbohydrate derivative catabolic process#GO:1901136;amino sugar metabolic process#GO:0006040;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 isomerase#PC00135 N-acetylglucosamine metabolism#P02756>Glucosamine-6-phosphate deaminase#P03041 HUMAN|HGNC=3706|UniProtKB=O43520 O43520 ATP8B1 PTHR24092:SF48 PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE PHOSPHOLIPID-TRANSPORTING ATPASE IC intramembrane lipid carrier activity#GO:0140303;molecular carrier activity#GO:0140104;lipid carrier activity#GO:0005319;transporter activity#GO:0005215;ATPase-coupled intramembrane lipid carrier activity#GO:0140326;ATP-dependent activity#GO:0140657 lipid translocation#GO:0034204;organophosphate ester transport#GO:0015748;Golgi organization#GO:0007030;cellular component organization#GO:0016043;regulation of biological quality#GO:0065008;localization#GO:0051179;lipid localization#GO:0010876;membrane organization#GO:0061024;endomembrane system organization#GO:0010256;biological regulation#GO:0065007;phospholipid translocation#GO:0045332;phospholipid transport#GO:0015914;lipid transport#GO:0006869;cellular process#GO:0009987;organelle organization#GO:0006996;macromolecule localization#GO:0033036;regulation of membrane lipid distribution#GO:0097035;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;transport#GO:0006810 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;trans-Golgi network#GO:0005802;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cell periphery#GO:0071944;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020 transporter#PC00227;primary active transporter#PC00068 HUMAN|HGNC=8213|UniProtKB=Q8NH94 Q8NH94 OR1L1 PTHR48001:SF51 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 1L1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 cell communication#GO:0007154;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=1139|UniProtKB=P78410 P78410 BTN3A2 PTHR24100:SF115 BUTYROPHILIN BUTYROPHILIN SUBFAMILY 3 MEMBER A2 protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488 immune response-regulating signaling pathway#GO:0002764;regulation of biological process#GO:0050789;signaling#GO:0023052;response to stimulus#GO:0050896;immune system process#GO:0002376;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;positive regulation of immune system process#GO:0002684;regulation of multicellular organismal process#GO:0051239;antigen receptor-mediated signaling pathway#GO:0050851;cell surface receptor signaling pathway#GO:0007166;immune response-activating signaling pathway#GO:0002757;cellular response to stimulus#GO:0051716;immune response-activating cell surface receptor signaling pathway#GO:0002429;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of immune response#GO:0050776;cell communication#GO:0007154;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cytokine production#GO:0001817;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;positive regulation of response to stimulus#GO:0048584;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;T cell receptor signaling pathway#GO:0050852;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=4670|UniProtKB=Q9BX10 Q9BX10 GTPBP2 PTHR43721:SF3 ELONGATION FACTOR TU-RELATED GTP-BINDING PROTEIN 2 translation elongation factor activity#GO:0003746;translation factor activity#GO:0180051 gene expression#GO:0010467;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;translational elongation#GO:0006414;metabolic process#GO:0008152;translation#GO:0006412 translation elongation factor#PC00222 HUMAN|HGNC=7662|UniProtKB=Q15080 Q15080 NCF4 PTHR15706:SF20 SH3 MULTIPLE DOMAIN NEUTROPHIL CYTOSOL FACTOR 4 molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;enzyme activator activity#GO:0008047 superoxide metabolic process#GO:0006801;metabolic process#GO:0008152;reactive oxygen species metabolic process#GO:0072593;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;plasma membrane#GO:0005886;membrane#GO:0016020;oxidoreductase complex#GO:1990204;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494 scaffold/adaptor protein#PC00226 HUMAN|HGNC=8534|UniProtKB=P56373 P56373 P2RX3 PTHR10125:SF8 P2X PURINOCEPTOR P2X PURINOCEPTOR 3 monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic cation channel activity#GO:0005261;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;ligand-gated monoatomic cation channel activity#GO:0099094;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836 monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;monoatomic ion transmembrane transport#GO:0034220;calcium ion transmembrane transport#GO:0070588;cellular process#GO:0009987;monoatomic cation transport#GO:0006812;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;calcium ion transport#GO:0006816;transport#GO:0006810 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ligand-gated ion channel#PC00141 HUMAN|HGNC=29161|UniProtKB=Q9Y2H8 Q9Y2H8 ZNF510 PTHR24392:SF63 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 510 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=18238|UniProtKB=P57735 P57735 RAB25 PTHR47979:SF8 DRAB11-RELATED RAS-RELATED PROTEIN RAB-25 nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;GTPase activity#GO:0003924;ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;guanyl nucleotide binding#GO:0019001;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818 exocytosis#GO:0006887;secretion by cell#GO:0032940;localization#GO:0051179;secretion#GO:0046903;establishment of localization#GO:0051234;transport#GO:0006810;export from cell#GO:0140352;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768;Golgi apparatus#GO:0005794;recycling endosome#GO:0055037 G-protein#PC00020;small GTPase#PC00208 HUMAN|HGNC=9898|UniProtKB=Q9NTZ6 Q9NTZ6 RBM12 PTHR13976:SF31 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED RNA-BINDING PROTEIN 12 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA splicing#GO:0043484 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;nucleoplasm#GO:0005654;organelle#GO:0043226;protein-containing complex#GO:0032991;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 RNA processing factor#PC00147;RNA splicing factor#PC00148;RNA metabolism protein#PC00031 HUMAN|HGNC=30509|UniProtKB=Q8N729 Q8N729 NPW PTHR28553:SF2 NEUROPEPTIDE B NEUROPEPTIDE W protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488;G protein-coupled receptor binding#GO:0001664 signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;multicellular organismal process#GO:0032501;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;feeding behavior#GO:0007631;G protein-coupled receptor signaling pathway#GO:0007186 HUMAN|HGNC=8823|UniProtKB=P16284 P16284 PECAM1 PTHR11481:SF5 IMMUNOGLOBULIN FC RECEPTOR PLATELET ENDOTHELIAL CELL ADHESION MOLECULE transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 regulation of biological process#GO:0050789;signal transduction#GO:0007165;immune response#GO:0006955;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell-cell adhesion#GO:0098609;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell adhesion#GO:0007155;cell surface receptor signaling pathway#GO:0007166;immune system process#GO:0002376;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell surface#GO:0009986;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=26821|UniProtKB=Q6ZP82 Q6ZP82 CCDC141 PTHR42757:SF44 IGLON FAMILY OF IMMUNOGLOBULIN SUPERFAMILY-RELATED COILED-COIL DOMAIN-CONTAINING PROTEIN 141 cell-cell adhesion#GO:0098609;cell adhesion#GO:0007155;cellular process#GO:0009987;heterophilic cell-cell adhesion#GO:0007157 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 immunoglobulin#PC00123 HUMAN|HGNC=13094|UniProtKB=Q9Y508 Q9Y508 RNF114 PTHR46016:SF3 ZINC FINGER, RING/FYVE/PHD-TYPE E3 UBIQUITIN-PROTEIN LIGASE RNF114 aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746 cellular process#GO:0009987;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;protein modification by small protein conjugation or removal#GO:0070647;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538 HUMAN|HGNC=16944|UniProtKB=Q96I25 Q96I25 RBM17 PTHR13288:SF9 SPLICING FACTOR 45 SPF45 SPLICING FACTOR 45 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;alternative mRNA splicing, via spliceosome#GO:0000380;macromolecule metabolic process#GO:0043170;mRNA splicing, via spliceosome#GO:0000398;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070 RNA processing factor#PC00147;RNA splicing factor#PC00148 HUMAN|HGNC=5432|UniProtKB=P17181 P17181 IFNAR1 PTHR20859:SF54 INTERFERON/INTERLEUKIN RECEPTOR INTERFERON ALPHA_BETA RECEPTOR 1 signaling receptor activity#GO:0038023;immune receptor activity#GO:0140375;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;cytokine receptor activity#GO:0004896 cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;type I interferon-mediated signaling pathway#GO:0060337;immune system process#GO:0002376;cytokine-mediated signaling pathway#GO:0019221;response to peptide#GO:1901652;cell communication#GO:0007154;cellular process#GO:0009987;immune response#GO:0006955;signal transduction#GO:0007165;defense response to symbiont#GO:0140546;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;response to other organism#GO:0051707;biological regulation#GO:0065007;defense response to other organism#GO:0098542;response to cytokine#GO:0034097;response to chemical#GO:0042221;cell surface receptor signaling pathway#GO:0007166;defense response#GO:0006952;response to external stimulus#GO:0009605;innate immune response#GO:0045087 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Cytokine receptor#P00866 HUMAN|HGNC=2317|UniProtKB=Q96A23 Q96A23 CPNE4 PTHR10857:SF4 COPINE COPINE-4 lipid binding#GO:0008289;binding#GO:0005488;phospholipid binding#GO:0005543 cellular response to chemical stimulus#GO:0070887;response to metal ion#GO:0010038;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to chemical#GO:0042221;response to stimulus#GO:0050896;response to calcium ion#GO:0051592 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 calcium-binding protein#PC00060 HUMAN|HGNC=6390|UniProtKB=Q9UIL4 Q9UIL4 KIF25 PTHR24115:SF421 KINESIN-RELATED KINESIN-LIKE PROTEIN KIF25 hydrolase activity, acting on acid anhydrides#GO:0016817;cytoskeletal protein binding#GO:0008092;cytoskeletal motor activity#GO:0003774;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP-dependent activity#GO:0140657;protein binding#GO:0005515;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543;tubulin binding#GO:0015631;ribonucleoside triphosphate phosphatase activity#GO:0017111;isomerase activity#GO:0016853;microtubule binding#GO:0008017;polypeptide conformation or assembly isomerase activity#GO:0120544;hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887;microtubule motor activity#GO:0003777 microtubule-based process#GO:0007017;microtubule-based movement#GO:0007018;cellular process#GO:0009987 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;microtubule#GO:0005874;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule cytoskeleton#GO:0015630;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;cytoskeleton#GO:0005856;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=26579|UniProtKB=Q6UXU6 Q6UXU6 TMEM92 PTHR31359:SF31 TRANSMEMBRANE PROTEIN 92 TRANSMEMBRANE PROTEIN 92 HUMAN|HGNC=21161|UniProtKB=Q6AZZ1 Q6AZZ1 TRIM68 PTHR24103:SF89 E3 UBIQUITIN-PROTEIN LIGASE TRIM E3 UBIQUITIN-PROTEIN LIGASE TRIM68 aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746 immune system process#GO:0002376;regulation of macromolecule metabolic process#GO:0060255;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;innate immune response#GO:0045087;response to external stimulus#GO:0009605;regulation of gene expression#GO:0010468;defense response#GO:0006952;defense response to other organism#GO:0098542;biological regulation#GO:0065007;response to other organism#GO:0051707;response to biotic stimulus#GO:0009607;regulation of metabolic process#GO:0019222;response to stress#GO:0006950;regulation of macromolecule biosynthetic process#GO:0010556;immune response#GO:0006955;defense response to symbiont#GO:0140546 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;cytosol#GO:0005829 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=17813|UniProtKB=Q969P0 Q969P0 IGSF8 PTHR12207:SF22 V-SET AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN IMMUNOGLOBULIN SUPERFAMILY MEMBER 8 cellular anatomical structure#GO:0110165;membrane#GO:0016020 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=26204|UniProtKB=Q8NBP0 Q8NBP0 TTC13 PTHR44523:SF1 TETRATRICOPEPTIDE REPEAT PROTEIN 13 TETRATRICOPEPTIDE REPEAT PROTEIN 13 HUMAN|HGNC=19701|UniProtKB=Q8WXI2 Q8WXI2 CNKSR2 PTHR12844:SF21 CONNECTOR ENCHANCER OF KINASE SUPPRESSOR OF RAS CONNECTOR ENHANCER OF KINASE SUPPRESSOR OF RAS 2 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 cell surface receptor signaling pathway#GO:0007166;cellular component organization or biogenesis#GO:0071840;organelle organization#GO:0006996;signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;synapse organization#GO:0050808;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;postsynaptic specialization organization#GO:0099084;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;cell junction organization#GO:0034330;regulation of cellular process#GO:0050794;postsynapse organization#GO:0099173;signaling#GO:0023052 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cell junction#GO:0030054;glutamatergic synapse#GO:0098978;synapse#GO:0045202;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=11097|UniProtKB=P28370 P28370 SMARCA1 PTHR10799:SF819 SNF2/RAD54 HELICASE FAMILY SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 1 catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;catalytic activity, acting on DNA#GO:0140097;nucleic acid binding#GO:0003676;binding#GO:0005488;ATP-dependent activity#GO:0140657;chromatin binding#GO:0003682;ATP-dependent activity, acting on DNA#GO:0008094;DNA binding#GO:0003677 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;negative regulation of biosynthetic process#GO:0009890;positive regulation of RNA biosynthetic process#GO:1902680;chromatin organization#GO:0006325;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;epigenetic regulation of gene expression#GO:0040029;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;heterochromatin formation#GO:0031507;cellular component organization or biogenesis#GO:0071840;negative regulation of gene expression, epigenetic#GO:0045814;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of macromolecule metabolic process#GO:0010604;cellular component assembly#GO:0022607;heterochromatin organization#GO:0070828;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;chromosome#GO:0005694;nucleus#GO:0005634;chromatin#GO:0000785;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231 DNA helicase#PC00011;DNA metabolism protein#PC00009 Wnt signaling pathway#P00057>SWI/SNF#P01435 HUMAN|HGNC=16697|UniProtKB=Q8WY21 Q8WY21 SORCS1 PTHR12106:SF8 SORTILIN RELATED VPS10 DOMAIN-CONTAINING RECEPTOR SORCS1 post-Golgi vesicle-mediated transport#GO:0006892;localization#GO:0051179;vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;transport#GO:0006810;cellular process#GO:0009987;Golgi vesicle transport#GO:0048193 membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HUMAN|HGNC=10431|UniProtKB=Q15349 Q15349 RPS6KA2 PTHR24351:SF213 RIBOSOMAL PROTEIN S6 KINASE RIBOSOMAL PROTEIN S6 KINASE ALPHA-2 catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;TORC1 signaling#GO:0038202;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signaling#GO:0023052;biological regulation#GO:0065007;TOR signaling#GO:0031929;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 PDGF signaling pathway#P00047>p90RSK#P01142;Interleukin signaling pathway#P00036>p90RSK#P00964;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>P90 RSK#P00888;Ras Pathway#P04393>p90RSK#P04541 HUMAN|HGNC=1160|UniProtKB=Q96RR1 Q96RR1 TWNK PTHR12873:SF7 T7-LIKE MITOCHONDRIAL DNA HELICASE TWINKLE MTDNA HELICASE DNA helicase activity#GO:0003678;isomerase activity#GO:0016853;helicase activity#GO:0004386;catalytic activity, acting on DNA#GO:0140097;macromolecular conformation isomerase activity#GO:0120543;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;ATP-dependent activity, acting on DNA#GO:0008094;DNA binding#GO:0003677;ATP-dependent activity#GO:0140657;single-stranded DNA binding#GO:0003697;binding#GO:0005488;nucleic acid binding#GO:0003676 DNA metabolic process#GO:0006259;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;DNA-templated DNA replication#GO:0006261;mitochondrial DNA metabolic process#GO:0032042;cellular process#GO:0009987;DNA replication#GO:0006260;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;nucleobase-containing compound metabolic process#GO:0006139 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 DNA helicase#PC00011 HUMAN|HGNC=12289|UniProtKB=A0A0C4DH28 A0A0C4DH28 TRGV4 PTHR19256:SF67 T-CELL RECEPTOR GAMMA CHAIN T CELL RECEPTOR GAMMA VARIABLE 4 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=23628|UniProtKB=Q8NGU9 Q8NGU9 GPR150 PTHR24241:SF83 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR G PROTEIN-COUPLED RECEPTOR 150-RELATED molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 signaling#GO:0023052;cellular response to hormone stimulus#GO:0032870;regulation of cellular process#GO:0050794;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;cell communication#GO:0007154;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;biological regulation#GO:0065007;response to chemical#GO:0042221;cellular process#GO:0009987;signal transduction#GO:0007165;response to hormone#GO:0009725 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=7837|UniProtKB=Q9H2Z4 Q9H2Z4 NKX2-4 PTHR24340:SF40 HOMEOBOX PROTEIN NKX HOMEOBOX PROTEIN NKX-2.4 RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;developmental process#GO:0032502;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=11343|UniProtKB=P50502 P50502 ST13 PTHR45883:SF6 HSC70-INTERACTING PROTEIN HSC70-INTERACTING PROTEIN-RELATED binding#GO:0005488;protein-folding chaperone binding#GO:0051087;heat shock protein binding#GO:0031072;protein binding#GO:0005515;Hsp70 protein binding#GO:0030544 metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein folding#GO:0006457;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604 HUMAN|HGNC=1535|UniProtKB=Q06455 Q06455 RUNX1T1 PTHR10379:SF5 MTG8 ETO EIGHT TWENTY ONE PROTEIN PROTEIN CBFA2T1 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714 negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 transcription cofactor#PC00217;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=20313|UniProtKB=Q86WI1 Q86WI1 PKHD1L1 PTHR46769:SF3 POLYCYSTIC KIDNEY AND HEPATIC DISEASE 1 (AUTOSOMAL RECESSIVE)-LIKE 1 FIBROCYSTIN-L HUMAN|HGNC=10353|UniProtKB=P36578 P36578 RPL4 PTHR19431:SF5 60S RIBOSOMAL PROTEIN L4 LARGE RIBOSOMAL SUBUNIT PROTEIN UL4 structural molecule activity#GO:0005198;RNA binding#GO:0003723;structural constituent of ribosome#GO:0003735;binding#GO:0005488;nucleic acid binding#GO:0003676 cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;ribosome#GO:0005840;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904 ribosomal protein#PC00202;translational protein#PC00263 HUMAN|HGNC=10680|UniProtKB=P31040 P31040 SDHA PTHR11632:SF51 SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 anaerobic respiration#GO:0009061;respiratory electron transport chain#GO:0022904;cellular process#GO:0009987;mitochondrial ATP synthesis coupled electron transport#GO:0042775;electron transport chain#GO:0022900;aerobic respiration#GO:0009060;energy derivation by oxidation of organic compounds#GO:0015980;cellular respiration#GO:0045333;ATP synthesis coupled electron transport#GO:0042773;oxidative phosphorylation#GO:0006119;mitochondrial electron transport, succinate to ubiquinone#GO:0006121;generation of precursor metabolites and energy#GO:0006091;aerobic electron transport chain#GO:0019646;metabolic process#GO:0008152 protein-containing complex#GO:0032991;cytoplasm#GO:0005737;plasma membrane#GO:0005886;oxidoreductase complex#GO:1990204;membrane#GO:0016020;cell periphery#GO:0071944;respiratory chain complex#GO:0098803;respiratory chain complex II (succinate dehydrogenase)#GO:0045273;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;catalytic complex#GO:1902494 dehydrogenase#PC00092 HUMAN|HGNC=6052|UniProtKB=P20839 P20839 IMPDH1 PTHR11911:SF74 INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 1 oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;nucleotide biosynthetic process#GO:0009165;ribonucleotide metabolic process#GO:0009259;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;small molecule metabolic process#GO:0044281;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;ribonucleoside triphosphate biosynthetic process#GO:0009201;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;ribose phosphate biosynthetic process#GO:0046390;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;organophosphate biosynthetic process#GO:0090407;purine nucleoside triphosphate biosynthetic process#GO:0009145;nucleoside triphosphate metabolic process#GO:0009141;nucleoside phosphate metabolic process#GO:0006753;primary metabolic process#GO:0044238;purine nucleoside triphosphate metabolic process#GO:0009144;nucleoside phosphate biosynthetic process#GO:1901293;purine ribonucleoside triphosphate biosynthetic process#GO:0009206;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;nucleoside triphosphate biosynthetic process#GO:0009142;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;purine ribonucleoside triphosphate metabolic process#GO:0009205;carbohydrate derivative metabolic process#GO:1901135 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 dehydrogenase#PC00092 De novo purine biosynthesis#P02738>IMP dehydrogenase#P02895 HUMAN|HGNC=12463|UniProtKB=P0CG47 P0CG47 UBB PTHR10666:SF437 UBIQUITIN POLYUBIQUITIN-B structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;catabolic process#GO:0009056;protein modification process#GO:0036211;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;protein modification by small protein conjugation#GO:0032446;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein modification by small protein conjugation or removal#GO:0070647;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632 intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;cytosolic ribosome#GO:0022626;nucleus#GO:0005634;ribosome#GO:0005840;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=6561|UniProtKB=P09382 P09382 LGALS1 PTHR11346:SF97 GALECTIN GALECTIN-1 protein binding#GO:0005515;carbohydrate binding#GO:0030246;extracellular matrix binding#GO:0050840;oligosaccharide binding#GO:0070492;binding#GO:0005488;laminin binding#GO:0043236 extracellular matrix protein#PC00102 HUMAN|HGNC=1546|UniProtKB=P50454 P50454 SERPINH1 PTHR11461:SF27 SERINE PROTEASE INHIBITOR, SERPIN SERPIN H1 peptidase regulator activity#GO:0061134;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;molecular function inhibitor activity#GO:0140678;serine-type endopeptidase inhibitor activity#GO:0004867;enzyme regulator activity#GO:0030234;enzyme inhibitor activity#GO:0004857;molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866 external encapsulating structure organization#GO:0045229;collagen fibril organization#GO:0030199;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;extracellular structure organization#GO:0043062;cellular component organization#GO:0016043 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;extracellular region#GO:0005576;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 protease inhibitor#PC00191 HUMAN|HGNC=21354|UniProtKB=Q86XR7 Q86XR7 TICAM2 PTHR47230:SF2 TIR DOMAIN-CONTAINING ADAPTER MOLECULE 1 TIR DOMAIN-CONTAINING ADAPTER MOLECULE 2 signaling adaptor activity#GO:0035591;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 toll-like receptor signaling pathway#GO:0002224;regulation of biological process#GO:0050789;immune response-regulating signaling pathway#GO:0002764;positive regulation of multicellular organismal process#GO:0051240;response to stimulus#GO:0050896;signaling#GO:0023052;immune system process#GO:0002376;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of signaling#GO:0023056;positive regulation of immune system process#GO:0002684;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;regulation of response to external stimulus#GO:0032101;regulation of multicellular organismal process#GO:0051239;immune response-activating signaling pathway#GO:0002757;positive regulation of response to external stimulus#GO:0032103;positive regulation of canonical NF-kappaB signal transduction#GO:0043123;positive regulation of signal transduction#GO:0009967;innate immune response-activating signaling pathway#GO:0002758;positive regulation of type I interferon production#GO:0032481;cellular response to stimulus#GO:0051716;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of immune system process#GO:0002682;positive regulation of cytokine production#GO:0001819;regulation of cell communication#GO:0010646;regulation of response to biotic stimulus#GO:0002831;regulation of immune response#GO:0050776;regulation of defense response#GO:0031347;positive regulation of biosynthetic process#GO:0009891;cell communication#GO:0007154;regulation of cytokine production#GO:0001817;activation of innate immune response#GO:0002218;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of cellular process#GO:0048522;regulation of canonical NF-kappaB signal transduction#GO:0043122;positive regulation of innate immune response#GO:0045089;positive regulation of response to stimulus#GO:0048584;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of response to stress#GO:0080134;positive regulation of immune response#GO:0050778;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of defense response#GO:0031349;regulation of response to stimulus#GO:0048583;regulation of innate immune response#GO:0045088;regulation of biosynthetic process#GO:0009889;positive regulation of gene expression#GO:0010628;positive regulation of response to biotic stimulus#GO:0002833;pattern recognition receptor signaling pathway#GO:0002221;regulation of gene expression#GO:0010468 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular vesicle#GO:0097708;vesicle#GO:0031982;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endosome#GO:0005768 scaffold/adaptor protein#PC00226 Toll receptor signaling pathway#P00054>TRIF#P01344 HUMAN|HGNC=6174|UniProtKB=Q9Y287 Q9Y287 ITM2B PTHR10962:SF4 INTEGRAL TRANSMEMBRANE PROTEIN 2 INTEGRAL MEMBRANE PROTEIN 2B binding#GO:0005488;peptide binding#GO:0042277 negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;negative regulation of cellular process#GO:0048523;regulation of biosynthetic process#GO:0009889;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of protein metabolic process#GO:0051246;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;plasma membrane#GO:0005886;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cell periphery#GO:0071944;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794 HUMAN|HGNC=6162|UniProtKB=P26010 P26010 ITGB7 PTHR10082:SF36 INTEGRIN BETA SUBUNIT INTEGRIN BETA-7 integrin binding#GO:0005178;protein-containing complex binding#GO:0044877;protein binding#GO:0005515;cell adhesion molecule binding#GO:0050839;signaling receptor binding#GO:0005102;binding#GO:0005488 cell adhesion mediated by integrin#GO:0033627;cell surface receptor signaling pathway#GO:0007166;leukocyte migration#GO:0050900;signal transduction#GO:0007165;cellular process#GO:0009987;cell-cell adhesion#GO:0098609;biological regulation#GO:0065007;cell migration#GO:0016477;cell-matrix adhesion#GO:0007160;cell adhesion#GO:0007155;immune system process#GO:0002376;cell-substrate adhesion#GO:0031589;cell communication#GO:0007154;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;integrin-mediated signaling pathway#GO:0007229;signaling#GO:0023052;response to stimulus#GO:0050896;cell motility#GO:0048870;regulation of cellular process#GO:0050794 signaling receptor complex#GO:0043235;cell junction#GO:0030054;integrin complex#GO:0008305;anchoring junction#GO:0070161;membrane protein complex#GO:0098796;membrane#GO:0016020;protein complex involved in cell adhesion#GO:0098636;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;cell surface#GO:0009986;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;focal adhesion#GO:0005925;cell-substrate junction#GO:0030055 integrin#PC00126 Integrin signalling pathway#P00034>Integrin beta#P00931;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Integrin#P00853 HUMAN|HGNC=9888|UniProtKB=Q15291 Q15291 RBBP5 PTHR44040:SF1 RETINOBLASTOMA-BINDING PROTEIN 5 RETINOBLASTOMA-BINDING PROTEIN 5 Set1C/COMPASS complex#GO:0048188;nuclear protein-containing complex#GO:0140513;histone methyltransferase complex#GO:0035097;transferase complex#GO:1990234;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;methyltransferase complex#GO:0034708;organelle lumen#GO:0043233 HUMAN|HGNC=18188|UniProtKB=Q9UM00 Q9UM00 TMCO1 PTHR20917:SF1 PNAS-RELATED CALCIUM LOAD-ACTIVATED CALCIUM CHANNEL channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;passive transmembrane transporter activity#GO:0022803;transporter activity#GO:0005215;calcium channel activity#GO:0005262;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873 homeostatic process#GO:0042592;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion homeostasis#GO:0050801;intracellular calcium ion homeostasis#GO:0006874;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;inorganic ion homeostasis#GO:0098771;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;calcium ion homeostasis#GO:0055074 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789 HUMAN|HGNC=26597|UniProtKB=Q6PF15 Q6PF15 KLHL35 PTHR24412:SF187 KELCH PROTEIN KELCH-LIKE PROTEIN 35 ubiquitin-like ligase-substrate adaptor activity#GO:1990756;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;enzyme-substrate adaptor activity#GO:0140767 primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511 cullin-RING ubiquitin ligase complex#GO:0031461;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;Cul3-RING ubiquitin ligase complex#GO:0031463;ubiquitin ligase complex#GO:0000151 scaffold/adaptor protein#PC00226 HUMAN|HGNC=5781|UniProtKB=A0A0C4DH68 A0A0C4DH68 IGKV2-24 PTHR23267:SF379 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN KAPPA VARIABLE 2-24-RELATED immune response#GO:0006955;immune system process#GO:0002376;response to stimulus#GO:0050896 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=1118|UniProtKB=Q10588 Q10588 BST1 PTHR10912:SF4 ADP-RIBOSYL CYCLASE ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE 2 hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;catalytic activity#GO:0003824 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 metabolite interconversion enzyme#PC00262;cyclase#PC00079 HUMAN|HGNC=1421|UniProtKB=O43772 O43772 SLC25A20 PTHR45624:SF56 MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED MITOCHONDRIAL CARNITINE_ACYLCARNITINE CARRIER PROTEIN transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;quaternary ammonium group transmembrane transporter activity#GO:0015651 cellular process#GO:0009987;establishment of localization in cell#GO:0051649;nitrogen compound transport#GO:0071705;quaternary ammonium group transport#GO:0015697;mitochondrial transport#GO:0006839;transport#GO:0006810;intracellular transport#GO:0046907;transmembrane transport#GO:0055085;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179 mitochondrion#GO:0005739;mitochondrial envelope#GO:0005740;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 transporter#PC00227 HUMAN|HGNC=25251|UniProtKB=Q9H095 Q9H095 DRC9 PTHR14871:SF1 DYNEIN REGULATORY COMPLEX PROTEIN 9 DYNEIN REGULATORY COMPLEX PROTEIN 9 cilium assembly#GO:0060271;cellular component organization#GO:0016043;sperm motility#GO:0097722;cell differentiation#GO:0030154;cell projection organization#GO:0030030;gamete generation#GO:0007276;cellular process involved in reproduction in multicellular organism#GO:0022412;cell development#GO:0048468;spermatid differentiation#GO:0048515;cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;cilium-dependent cell motility#GO:0060285;sperm flagellum assembly#GO:0120316;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cilium movement involved in cell motility#GO:0060294;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;motile cilium assembly#GO:0044458;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;developmental process involved in reproduction#GO:0003006;germ cell development#GO:0007281;microtubule-based movement#GO:0007018;cell motility#GO:0048870;reproductive process#GO:0022414;organelle assembly#GO:0070925;sexual reproduction#GO:0019953;spermatid development#GO:0007286;microtubule bundle formation#GO:0001578;anatomical structure development#GO:0048856;microtubule cytoskeleton organization#GO:0000226;axoneme assembly#GO:0035082;multicellular organismal reproductive process#GO:0048609;male gamete generation#GO:0048232;plasma membrane bounded cell projection organization#GO:0120036;flagellated sperm motility#GO:0030317;plasma membrane bounded cell projection assembly#GO:0120031;spermatogenesis#GO:0007283;developmental process#GO:0032502;cellular developmental process#GO:0048869;sperm axoneme assembly#GO:0007288 cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;sperm flagellum#GO:0036126;cellular anatomical structure#GO:0110165;organelle#GO:0043226;motile cilium#GO:0031514;cilium#GO:0005929;9+2 motile cilium#GO:0097729;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=871|UniProtKB=Q9UII2 Q9UII2 ATP5IF1 PTHR23407:SF6 ATPASE INHIBITOR/5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE ATPASE INHIBITOR, MITOCHONDRIAL enzyme binding#GO:0019899;binding#GO:0005488;ligase activity, forming carbon-nitrogen bonds#GO:0016879;molecular function inhibitor activity#GO:0140678;protein binding#GO:0005515;ligase activity#GO:0016874;catalytic activity#GO:0003824;molecular function regulator activity#GO:0098772 porphyrin-containing compound metabolic process#GO:0006778;pigment biosynthetic process#GO:0046148;developmental process#GO:0032502;metabolic process#GO:0008152;multicellular organismal-level homeostasis#GO:0048871;cellular developmental process#GO:0048869;cellular process#GO:0009987;pigment metabolic process#GO:0042440;heme metabolic process#GO:0042168;biosynthetic process#GO:0009058;hemopoiesis#GO:0030097;multicellular organismal process#GO:0032501;tetrahydrofolate biosynthetic process#GO:0046654;homeostasis of number of cells#GO:0048872;immune system process#GO:0002376;tetrapyrrole metabolic process#GO:0033013;tetrahydrofolate metabolic process#GO:0046653;anatomical structure development#GO:0048856;erythrocyte differentiation#GO:0030218;porphyrin-containing compound biosynthetic process#GO:0006779;modified amino acid metabolic process#GO:0006575;heme biosynthetic process#GO:0006783;cell development#GO:0048468;homeostatic process#GO:0042592;myeloid cell differentiation#GO:0030099;pteridine-containing compound metabolic process#GO:0042558;folic acid-containing compound metabolic process#GO:0006760;small molecule metabolic process#GO:0044281;cell differentiation#GO:0030154;tetrapyrrole biosynthetic process#GO:0033014 mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 ligase#PC00142 HUMAN|HGNC=14711|UniProtKB=Q8NGM8 Q8NGM8 OR6M1 PTHR26454:SF51 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 6M1 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=24847|UniProtKB=Q9H4M3 Q9H4M3 FBXO44 PTHR12125:SF13 F-BOX ONLY PROTEIN 6-LIKE PROTEIN F-BOX ONLY PROTEIN 44 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=13996|UniProtKB=Q9NQV5 Q9NQV5 PRDM11 PTHR16515:SF37 PR DOMAIN ZINC FINGER PROTEIN PR DOMAIN ZINC FINGER PROTEIN 2-RELATED DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HUMAN|HGNC=17005|UniProtKB=O75829 O75829 CNMD PTHR14064:SF6 CHONDROMODULIN-RELATED LEUKOCYTE CELL-DERIVED CHEMOTAXIN 1 regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of developmental process#GO:0050793;regulation of multicellular organismal process#GO:0051239;negative regulation of biological process#GO:0048519;negative regulation of multicellular organismal process#GO:0051241;negative regulation of cell population proliferation#GO:0008285;regulation of biological process#GO:0050789;regulation of multicellular organismal development#GO:2000026;regulation of cell population proliferation#GO:0042127;negative regulation of angiogenesis#GO:0016525;regulation of anatomical structure morphogenesis#GO:0022603;regulation of angiogenesis#GO:0045765;regulation of vasculature development#GO:1901342;negative regulation of cellular process#GO:0048523 HUMAN|HGNC=13707|UniProtKB=Q8WXD2 Q8WXD2 SCG3 PTHR17388:SF2 SECRETOGRANIN III SECRETOGRANIN-3 macromolecule localization#GO:0033036;intracellular protein localization#GO:0008104;localization#GO:0051179;protein localization to organelle#GO:0033365 membrane#GO:0016020;secretory vesicle#GO:0099503;vesicle membrane#GO:0012506;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;secretory granule membrane#GO:0030667;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=17546|UniProtKB=Q8WYK2 Q8WYK2 JDP2 PTHR23351:SF10 FOS TRANSCRIPTION FACTOR-RELATED JUN DIMERIZATION PROTEIN 2 RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 basic leucine zipper transcription factor#PC00056 Apoptosis signaling pathway#P00006>ATF#P00302 HUMAN|HGNC=14670|UniProtKB=Q9P218 Q9P218 COL20A1 PTHR24020:SF39 COLLAGEN ALPHA COLLAGEN ALPHA-1(XX) CHAIN cellular anatomical structure#GO:0110165;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576 extracellular matrix structural protein#PC00103 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>EMC#P00863;Integrin signalling pathway#P00034>Collagen#P00922 HUMAN|HGNC=11132|UniProtKB=P60880 P60880 SNAP25 PTHR19305:SF5 SYNAPTOSOMAL ASSOCIATED PROTEIN SYNAPTOSOMAL-ASSOCIATED PROTEIN 25 SNAP receptor activity#GO:0005484;syntaxin binding#GO:0019905;protein binding#GO:0005515;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;SNARE binding#GO:0000149;binding#GO:0005488 membrane organization#GO:0061024;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;neurotransmitter secretion#GO:0007269;membrane fusion#GO:0061025;synaptic vesicle membrane organization#GO:0048499;establishment of localization#GO:0051234;synaptic vesicle cycle#GO:0099504;transport#GO:0006810;anterograde trans-synaptic signaling#GO:0098916;vesicle fusion#GO:0006906;signal release from synapse#GO:0099643;chemical synaptic transmission#GO:0007268;localization#GO:0051179;cell communication#GO:0007154;secretion#GO:0046903;signal release#GO:0023061;trans-synaptic signaling#GO:0099537;synaptic vesicle fusion to presynaptic active zone membrane#GO:0031629;cellular component assembly#GO:0022607;organelle fusion#GO:0048284;vesicle-mediated transport#GO:0016192;endomembrane system organization#GO:0010256;neurotransmitter transport#GO:0006836;organelle membrane fusion#GO:0090174;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;synaptic signaling#GO:0099536;establishment of localization in cell#GO:0051649;synaptic vesicle exocytosis#GO:0016079;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;vesicle-mediated transport in synapse#GO:0099003;exocytosis#GO:0006887;vesicle organization#GO:0016050;protein-containing complex organization#GO:0043933;regulated exocytosis#GO:0045055;vesicle fusion to plasma membrane#GO:0099500;exocytic process#GO:0140029;signaling#GO:0023052;export from cell#GO:0140352;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;regulation of biological process#GO:0050789;cellular localization#GO:0051641;secretion by cell#GO:0032940 cell periphery#GO:0071944;membrane#GO:0016020;membrane protein complex#GO:0098796;cytoplasm#GO:0005737;plasma membrane#GO:0005886;SNARE complex#GO:0031201;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150;SNARE protein#PC00034 Metabotropic glutamate receptor group II pathway#P00040>SNARE Complex#P01049;Opioid proopiomelanocortin pathway#P05917>SNARE Complex#P06005;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>SNARE Complex#P01066;Oxytocin receptor mediated signaling pathway#P04391>SNARE Complex#P04532;Thyrotropin-releasing hormone receptor signaling pathway#P04394>SNARE Complex#P04582;Synaptic vesicle trafficking#P05734>SNAP-25#P05778;Metabotropic glutamate receptor group III pathway#P00039>SNARE Complex#P01042;Ionotropic glutamate receptor pathway#P00037>SNARE Complex#P01013;Cortocotropin releasing factor receptor signaling pathway#P04380>SNARE Complex#P04457;Nicotinic acetylcholine receptor signaling pathway#P00044>SNARE Complex#P01091;5HT1 type receptor mediated signaling pathway#P04373>SNARE Complex#P04405;Beta1 adrenergic receptor signaling pathway#P04377>SNARE Complex#P04435;Adrenaline and noradrenaline biosynthesis#P00001>SNARE#P00072;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>SNARE Complex#P01079;5HT4 type receptor mediated signaling pathway#P04376>SNARE Complex#P04428;Alpha adrenergic receptor signaling pathway#P00002>SNARE#P00074;Opioid proenkephalin pathway#P05915>SNARE Complex#P05986;5HT2 type receptor mediated signaling pathway#P04374>SNARE Complex#P04415;5HT3 type receptor mediated signaling pathway#P04375>SNARE Complex#P04423;Beta3 adrenergic receptor signaling pathway#P04379>SNARE Complex#P04447;Dopamine receptor mediated signaling pathway#P05912>SNARE Complex#P05956;Beta2 adrenergic receptor signaling pathway#P04378>SNARE Complex#P04442;Opioid prodynorphin pathway#P05916>SNARE Complex#P05996 HUMAN|HGNC=26802|UniProtKB=Q8TBE1 Q8TBE1 CNIH3 PTHR12290:SF12 CORNICHON-RELATED PROTEIN CORNICHON HOMOLOG 3 trans-synaptic signaling#GO:0099537;localization#GO:0051179;cell communication#GO:0007154;cellular localization#GO:0051641;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;anterograde trans-synaptic signaling#GO:0098916;signaling#GO:0023052;intracellular transport#GO:0046907;transport#GO:0006810;Golgi vesicle transport#GO:0048193;establishment of localization#GO:0051234;synaptic signaling#GO:0099536;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;synaptic transmission, glutamatergic#GO:0035249 cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;synapse#GO:0045202;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;coated vesicle#GO:0030135;COPII-coated ER to Golgi transport vesicle#GO:0030134;dendritic tree#GO:0097447;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;dendrite#GO:0030425;somatodendritic compartment#GO:0036477;cytoplasm#GO:0005737;endomembrane system#GO:0012505;neuron projection#GO:0043005;membrane#GO:0016020;organelle membrane#GO:0031090;cell junction#GO:0030054;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 membrane traffic protein#PC00150 HUMAN|HGNC=1240|UniProtKB=Q9UBS9 Q9UBS9 SUCO PTHR12953:SF10 MEMBRANE PROTEIN CH1 RELATED SUN DOMAIN-CONTAINING OSSIFICATION FACTOR biological regulation#GO:0065007;regulation of multicellular organismal process#GO:0051239;regulation of tissue remodeling#GO:0034103;regulation of biological process#GO:0050789;regulation of bone remodeling#GO:0046850 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;membrane#GO:0016020 structural protein#PC00211 HUMAN|HGNC=8009|UniProtKB=Q9P2S2 Q9P2S2 NRXN2 PTHR15036:SF52 PIKACHURIN-LIKE PROTEIN NEUREXIN-2 transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488;signaling receptor binding#GO:0005102;signaling receptor activity#GO:0038023;protein binding#GO:0005515;molecular transducer activity#GO:0060089 macromolecule localization#GO:0033036;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;developmental process#GO:0032502;system process#GO:0003008;intracellular protein localization#GO:0008104;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;cell junction organization#GO:0034330;postsynapse organization#GO:0099173;protein localization to cell junction#GO:1902414;organelle assembly#GO:0070925;cognition#GO:0050890;synapse organization#GO:0050808;localization#GO:0051179;cell communication#GO:0007154;anatomical structure development#GO:0048856;system development#GO:0048731;postsynaptic specialization organization#GO:0099084;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;signal transduction#GO:0007165;postsynaptic density assembly#GO:0097107;cellular process#GO:0009987;cellular component assembly#GO:0022607;nervous system development#GO:0007399;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;protein localization to synapse#GO:0035418;cell junction assembly#GO:0034329;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;synapse assembly#GO:0007416;signaling#GO:0023052;excitatory synapse assembly#GO:1904861;animal gross anatomical part developmental process#GO:0160108;nervous system process#GO:0050877;postsynaptic density organization#GO:0097106 cell periphery#GO:0071944;presynapse#GO:0098793;presynaptic active zone membrane#GO:0048787;membrane#GO:0016020;presynaptic membrane#GO:0042734;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;synapse#GO:0045202;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;synaptic membrane#GO:0097060;presynaptic active zone#GO:0048786;cell junction#GO:0030054 cell adhesion molecule#PC00069 HUMAN|HGNC=18182|UniProtKB=Q9ULQ1 Q9ULQ1 TPCN1 PTHR46474:SF1 TWO PORE CALCIUM CHANNEL PROTEIN 1 TWO PORE CHANNEL PROTEIN 1 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;lysosome#GO:0005764;lytic vacuole membrane#GO:0098852;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endosome membrane#GO:0010008;endosome#GO:0005768;vacuole#GO:0005773;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;lysosomal membrane#GO:0005765;vesicle membrane#GO:0012506;membrane#GO:0016020;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;lytic vacuole#GO:0000323;vacuolar membrane#GO:0005774 ion channel#PC00133 CCKR signaling map#P06959>TPC1/2#P07209 HUMAN|HGNC=13664|UniProtKB=Q9UPN3 Q9UPN3 MACF1 PTHR23169:SF25 ENVOPLAKIN MICROTUBULE-ACTIN CROSS-LINKING FACTOR 1, ISOFORMS 1_2_3_4_5 cellular component organization or biogenesis#GO:0071840;regulation of cell adhesion#GO:0030155;cytoskeleton organization#GO:0007010;regulation of cell-substrate adhesion#GO:0010810;biological regulation#GO:0065007;response to wounding#GO:0009611;response to stress#GO:0006950;organelle organization#GO:0006996;cellular process#GO:0009987;regulation of cell-matrix adhesion#GO:0001952;wound healing#GO:0042060;regulation of microtubule-based process#GO:0032886;intermediate filament-based process#GO:0045103;regulation of cell junction assembly#GO:1901888;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;intermediate filament cytoskeleton organization#GO:0045104;regulation of cellular component organization#GO:0051128;regulation of cellular component biogenesis#GO:0044087;cellular component organization#GO:0016043;regulation of biological process#GO:0050789 microtubule cytoskeleton#GO:0015630;membrane#GO:0016020;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;cytoskeleton#GO:0005856;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;intermediate filament#GO:0005882;actin cytoskeleton#GO:0015629;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;microtubule#GO:0005874;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622 intermediate filament binding protein#PC00130;intermediate filament#PC00129 HUMAN|HGNC=14672|UniProtKB=Q9H981 Q9H981 ACTR8 PTHR11937:SF13 ACTIN ACTIN-RELATED PROTEIN 8 mRNA binding#GO:0003729;structural constituent of cytoskeleton#GO:0005200;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723;structural molecule activity#GO:0005198 regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;double-strand break repair#GO:0006302;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;DNA damage response#GO:0006974;regulation of nucleobase-containing compound metabolic process#GO:0019219;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;response to stress#GO:0006950;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;INO80-type complex#GO:0097346;membrane-bounded organelle#GO:0043227;ATPase complex#GO:1904949;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;SWI/SNF superfamily-type complex#GO:0070603;chromosome#GO:0005694;organelle lumen#GO:0043233;Ino80 complex#GO:0031011;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;chromatin#GO:0000785;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974 actin and actin related protein#PC00039 HUMAN|HGNC=3513|UniProtKB=Q93063 Q93063 EXT2 PTHR11062:SF381 EXOSTOSIN HEPARAN SULFATE GLYCOSYLTRANSFERASE -RELATED EXOSTOSIN-2 acetylglucosaminyltransferase activity#GO:0008375;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;glucuronosyltransferase activity#GO:0015020;transferase activity#GO:0016740 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 glycosyltransferase#PC00111;transferase#PC00220 HUMAN|HGNC=973|UniProtKB=O75815 O75815 BCAR3 PTHR14247:SF10 BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3 HOMOLOG-LIKE PROTEIN BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3 cellular response to insulin stimulus#GO:0032869;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of MAPK cascade#GO:0043410;ERBB signaling pathway#GO:0038127;positive regulation of cellular process#GO:0048522;response to peptide hormone#GO:0043434;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;epidermal growth factor receptor signaling pathway#GO:0007173;cellular response to nitrogen compound#GO:1901699;positive regulation of response to stimulus#GO:0048584;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;response to nitrogen compound#GO:1901698;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;response to insulin#GO:0032868;positive regulation of signal transduction#GO:0009967;cellular response to peptide hormone stimulus#GO:0071375;regulation of cell communication#GO:0010646;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;regulation of MAPK cascade#GO:0043408;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular response to oxygen-containing compound#GO:1901701;response to hormone#GO:0009725;response to chemical#GO:0042221;regulation of signaling#GO:0023051;insulin receptor signaling pathway#GO:0008286;response to oxygen-containing compound#GO:1901700;regulation of intracellular signal transduction#GO:1902531;G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887;positive regulation of signaling#GO:0023056;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;signaling#GO:0023052;cellular response to hormone stimulus#GO:0032870;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495 HUMAN|HGNC=4091|UniProtKB=P28476 P28476 GABRR2 PTHR18945:SF197 NEUROTRANSMITTER GATED ION CHANNEL GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT RHO-2 monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;signaling receptor activity#GO:0038023;chloride channel activity#GO:0005254;neurotransmitter receptor activity#GO:0030594;monoatomic anion transmembrane transporter activity#GO:0008509;transporter activity#GO:0005215;transmembrane signaling receptor activity#GO:0004888;gated channel activity#GO:0022836;chloride transmembrane transporter activity#GO:0015108;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;molecular transducer activity#GO:0060089;monoatomic anion channel activity#GO:0005253;channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276 chloride transport#GO:0006821;transport#GO:0006810;establishment of localization#GO:0051234;synaptic signaling#GO:0099536;cellular process#GO:0009987;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;trans-synaptic signaling#GO:0099537;transmembrane transport#GO:0055085;localization#GO:0051179;cell communication#GO:0007154;chloride transmembrane transport#GO:1902476;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698;chemical synaptic transmission#GO:0007268;monoatomic anion transport#GO:0006820;regulation of biological process#GO:0050789;anterograde trans-synaptic signaling#GO:0098916;signaling#GO:0023052 signaling receptor complex#GO:0043235;cell junction#GO:0030054;membrane#GO:0016020;cell periphery#GO:0071944;protein-containing complex#GO:0032991;synapse#GO:0045202;cellular anatomical structure#GO:0110165;GABA-ergic synapse#GO:0098982;plasma membrane#GO:0005886 ligand-gated ion channel#PC00141 HUMAN|HGNC=8041|UniProtKB=P53384 P53384 NUBP1 PTHR23264:SF35 NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP1 iron-sulfur cluster binding#GO:0051536;binding#GO:0005488;small molecule binding#GO:0036094 cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;iron-sulfur cluster assembly#GO:0016226;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;cellular process#GO:0009987 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=28795|UniProtKB=Q9BV19 Q9BV19 C1orf50 PTHR14553:SF1 UNCHARACTERIZED PROTEIN C1ORF50 SIMILAR TO HUMAN CHROMOSOME 1 OPEN READING FRAME 50 HUMAN|HGNC=9246|UniProtKB=O75334 O75334 PPFIA2 PTHR12587:SF6 LAR INTERACTING PROTEIN LIP -RELATED PROTEIN LIPRIN-ALPHA-2 protein complex scaffold activity#GO:0140378;structural molecule activity#GO:0005198 cellular component organization or biogenesis#GO:0071840;cell junction organization#GO:0034330;synapse organization#GO:0050808;cellular process#GO:0009987;cellular component organization#GO:0016043 presynapse#GO:0098793;cellular anatomical structure#GO:0110165;synapse#GO:0045202;presynaptic active zone#GO:0048786;cell junction#GO:0030054 scaffold/adaptor protein#PC00226 HUMAN|HGNC=33908|UniProtKB=Q6NUM6 Q6NUM6 TYW1B PTHR13930:SF0 S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE TYW1-RELATED cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;gene expression#GO:0010467;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;carbohydrate derivative biosynthetic process#GO:1901137;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;tRNA modification#GO:0006400;RNA biosynthetic process#GO:0032774;RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412 lyase#PC00144 HUMAN|HGNC=22917|UniProtKB=Q9H5U6 Q9H5U6 ZCCHC4 PTHR13493:SF3 ZINC FINGER CCHC DOMAIN-CONTAINING RRNA N(6)-ADENOSINE-METHYLTRANSFERASE ZCCHC4 rRNA (adenine) methyltransferase activity#GO:0016433;catalytic activity, acting on a rRNA#GO:0140102;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;N-methyltransferase activity#GO:0008170;RNA methyltransferase activity#GO:0008173;catalytic activity, acting on RNA#GO:0140098;rRNA methyltransferase activity#GO:0008649;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;catalytic activity#GO:0003824 macromolecule methylation#GO:0043414;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;RNA methylation#GO:0001510;methylation#GO:0032259;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;rRNA modification#GO:0000154;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;rRNA methylation#GO:0031167;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467 organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 RNA methyltransferase#PC00033 HUMAN|HGNC=21575|UniProtKB=Q8N157 Q8N157 AHI1 PTHR44499:SF1 JOUBERIN JOUBERIN cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular component organization#GO:0016043;cilium assembly#GO:0060271;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cell projection organization#GO:0030030;organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031;cilium organization#GO:0044782;cellular component organization or biogenesis#GO:0071840;motile cilium assembly#GO:0044458 intracellular organelle#GO:0043229;cilium#GO:0005929;microtubule organizing center#GO:0005815;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=9221|UniProtKB=Q01860 Q01860 POU5F1 PTHR11636:SF86 POU DOMAIN POU DOMAIN, CLASS 5, TRANSCRIPTION FACTOR 1-RELATED sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular anatomical structure#GO:0005622;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=3823|UniProtKB=Q9H334 Q9H334 FOXP1 PTHR45796:SF3 FORKHEAD BOX P, ISOFORM C FORKHEAD BOX PROTEIN P1 sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulator activity#GO:0140110;DNA-binding transcription repressor activity#GO:0001217;transcription regulatory region nucleic acid binding#GO:0001067 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 winged helix/forkhead transcription factor#PC00246;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=15464|UniProtKB=Q9NQ38 Q9NQ38 SPINK5 PTHR10913:SF71 FOLLISTATIN-RELATED SERINE PROTEASE INHIBITOR KAZAL-TYPE 5 endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772;enzyme inhibitor activity#GO:0004857;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;serine-type endopeptidase inhibitor activity#GO:0004867;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414;peptidase regulator activity#GO:0061134 cellular process#GO:0009987;developmental process#GO:0032502;cellular developmental process#GO:0048869;cell differentiation#GO:0030154 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HUMAN|HGNC=16817|UniProtKB=Q96DF8 Q96DF8 ESS2 PTHR12940:SF0 ES-2 PROTEIN - RELATED SPLICING FACTOR ESS-2 HOMOLOG ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;nuclear protein-containing complex#GO:0140513;catalytic step 2 spliceosome#GO:0071013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;spliceosomal complex#GO:0005681;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=32372|UniProtKB=A2RUT3 A2RUT3 TMEM89 PTHR37869:SF1 TRANSMEMBRANE PROTEIN 89 TRANSMEMBRANE PROTEIN 89 HUMAN|HGNC=28314|UniProtKB=Q9BUK0 Q9BUK0 CHCHD7 PTHR46811:SF1 COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 7 COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 7 cellular component assembly#GO:0022607;mitochondrion organization#GO:0007005;mitochondrial respiratory chain complex assembly#GO:0033108;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=29269|UniProtKB=Q9P2E8 Q9P2E8 MARCHF4 PTHR46053:SF3 E3 UBIQUITIN-PROTEIN LIGASE MARCH4-LIKE E3 UBIQUITIN-PROTEIN LIGASE MARCHF4 ubiquitin-protein transferase activity#GO:0004842;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus subcompartment#GO:0098791;Golgi stack#GO:0005795;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=7899|UniProtKB=Q9NQX5 Q9NQX5 NPDC1 PTHR23352:SF2 NEURAL PROLIFERATION DIFFERENTIATION AND CONTROL PROTEIN-1 NPDC-1 PROTEIN NEURAL PROLIFERATION DIFFERENTIATION AND CONTROL PROTEIN 1 HUMAN|HGNC=9403|UniProtKB=P24723 P24723 PRKCH PTHR24356:SF192 SERINE/THREONINE-PROTEIN KINASE PROTEIN KINASE C ETA TYPE catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 non-receptor serine/threonine protein kinase#PC00167 Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>PKC#P01074;Oxytocin receptor mediated signaling pathway#P04391>PKC#P04533;Wnt signaling pathway#P00057>Protein Kinase C#P01458;CCKR signaling map#P06959>PKCeta#P07068;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>PKC#P00745;Thyrotropin-releasing hormone receptor signaling pathway#P04394>PKC#P04583;Alzheimer disease-amyloid secretase pathway#P00003>PKC#P00109;FGF signaling pathway#P00021>PKC#P00648;5HT2 type receptor mediated signaling pathway#P04374>PKC#P04420;Endothelin signaling pathway#P00019>PKC#P00568;Angiogenesis#P00005>PKC#P00219;VEGF signaling pathway#P00056>PKC#P01425;EGF receptor signaling pathway#P00018>PKC#P00565;Histamine H1 receptor mediated signaling pathway#P04385>PKC#P04487;Apoptosis signaling pathway#P00006>PKCs#P00318 HUMAN|HGNC=4472|UniProtKB=Q14330 Q14330 GPR18 PTHR24232:SF1 G-PROTEIN COUPLED RECEPTOR N-ARACHIDONYL GLYCINE RECEPTOR transmembrane signaling receptor activity#GO:0004888;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=6396|UniProtKB=O00505 O00505 KPNA3 PTHR23316:SF6 IMPORTIN ALPHA IMPORTIN SUBUNIT ALPHA-4 molecular carrier activity#GO:0140104;nucleocytoplasmic carrier activity#GO:0140142 nucleocytoplasmic transport#GO:0006913;NLS-bearing protein import into nucleus#GO:0006607;localization#GO:0051179;cellular localization#GO:0051641;nuclear transport#GO:0051169;protein import into nucleus#GO:0006606;protein transport#GO:0015031;protein localization to organelle#GO:0033365;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;import into nucleus#GO:0051170;protein localization to nucleus#GO:0034504;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 transporter#PC00227 HUMAN|HGNC=216|UniProtKB=Q13443 Q13443 ADAM9 PTHR11905:SF136 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 9 catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metalloendopeptidase activity#GO:0004222;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175 macromolecule metabolic process#GO:0043170;multicellular organism development#GO:0007275;animal organ development#GO:0048513;development of primary male sexual characteristics#GO:0046546;metabolic process#GO:0008152;developmental process#GO:0032502;development of primary sexual characteristics#GO:0045137;male sex differentiation#GO:0046661;multicellular organismal process#GO:0032501;gonad development#GO:0008406;male gonad development#GO:0008584;sex differentiation#GO:0007548;cellular process#GO:0009987;protein metabolic process#GO:0019538;anatomical structure development#GO:0048856;system development#GO:0048731;reproductive system development#GO:0061458;proteolysis#GO:0006508;animal gross anatomical part developmental process#GO:0160108;reproductive structure development#GO:0048608;reproductive process#GO:0022414;primary metabolic process#GO:0044238;developmental process involved in reproduction#GO:0003006 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;plasma membrane region#GO:0098590;cell periphery#GO:0071944;membrane#GO:0016020;side of membrane#GO:0098552;external side of plasma membrane#GO:0009897 metalloprotease#PC00153;protease#PC00190 Alzheimer disease-amyloid secretase pathway#P00003>MDC9#P00090 HUMAN|HGNC=18449|UniProtKB=P28838 P28838 LAP3 PTHR11963:SF39 LEUCINE AMINOPEPTIDASE-RELATED CYTOSOL AMINOPEPTIDASE catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;cellular process#GO:0009987;metabolic process#GO:0008152;proteolysis#GO:0006508;primary metabolic process#GO:0044238 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protease#PC00190;metalloprotease#PC00153 HUMAN|HGNC=5960|UniProtKB=O14920 O14920 IKBKB PTHR22969:SF7 IKB KINASE INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096 response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;signaling#GO:0023052;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;positive regulation of signaling#GO:0023056;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;response to peptide#GO:1901652;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;response to cytokine#GO:0034097;positive regulation of macromolecule metabolic process#GO:0010604;response to chemical#GO:0042221;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;positive regulation of canonical NF-kappaB signal transduction#GO:0043123;positive regulation of transcription by RNA polymerase II#GO:0045944;cell surface receptor signaling pathway#GO:0007166;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;regulation of cell communication#GO:0010646;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;regulation of DNA-templated transcription#GO:0006355;tumor necrosis factor-mediated signaling pathway#GO:0033209;cell communication#GO:0007154;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;cytokine-mediated signaling pathway#GO:0019221;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of response to stimulus#GO:0048584;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;regulation of signal transduction#GO:0009966;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;response to tumor necrosis factor#GO:0034612;regulation of canonical NF-kappaB signal transduction#GO:0043122;positive regulation of cellular process#GO:0048522;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;protein kinase complex#GO:1902911;serine/threonine protein kinase complex#GO:1902554;transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;transferase complex#GO:1990234 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 Apoptosis signaling pathway#P00006>IKK#P00313;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>IKK#P00871;Interleukin signaling pathway#P00036>Ikk#P00968;Toll receptor signaling pathway#P00054>IKKbeta#P01360;B cell activation#P00010>IKK#P00397;T cell activation#P00053>IKK#P01330;PDGF signaling pathway#P00047>Ikk#P01146 HUMAN|HGNC=8218|UniProtKB=Q8NGR2 Q8NGR2 OR1L6 PTHR48001:SF106 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 1L6 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell communication#GO:0007154;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=12877|UniProtKB=O75844 O75844 ZMPSTE24 PTHR10120:SF24 CAAX PRENYL PROTEASE 1 CAAX PRENYL PROTEASE 1 HOMOLOG catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metalloendopeptidase activity#GO:0004222;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;proteolysis#GO:0006508;metabolic process#GO:0008152;biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein processing#GO:0016485;primary metabolic process#GO:0044238 membrane#GO:0016020;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090 metalloprotease#PC00153 HUMAN|HGNC=27482|UniProtKB=Q4G148 Q4G148 GXYLT1 PTHR46012:SF3 IP22168P GLUCOSIDE XYLOSYLTRANSFERASE 1 xylosyltransferase activity#GO:0042285;glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194;pentosyltransferase activity#GO:0016763;UDP-xylosyltransferase activity#GO:0035252;transferase activity#GO:0016740;catalytic activity#GO:0003824 biosynthetic process#GO:0009058;carbohydrate derivative metabolic process#GO:1901135;protein O-linked glycosylation#GO:0006493;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152 HUMAN|HGNC=4637|UniProtKB=P46439 P46439 GSTM5 PTHR11571:SF249 GLUTATHIONE S-TRANSFERASE GLUTATHIONE S-TRANSFERASE MU 5 transferase activity#GO:0016740;catalytic activity#GO:0003824;glutathione transferase activity#GO:0004364;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765 cellular process#GO:0009987;glutathione metabolic process#GO:0006749;modified amino acid metabolic process#GO:0006575;sulfur compound metabolic process#GO:0006790;metabolic process#GO:0008152 transferase#PC00220 HUMAN|HGNC=17931|UniProtKB=Q9UJW9 Q9UJW9 SERTAD3 PTHR15530:SF0 SERTA DOMAIN-CONTAINING PROTEIN 3 SERTA DOMAIN-CONTAINING PROTEIN 3 regulation of biological process#GO:0050789;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=20655|UniProtKB=Q8TEU7 Q8TEU7 RAPGEF6 PTHR23113:SF222 GUANINE NUCLEOTIDE EXCHANGE FACTOR RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 6 GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;plasma membrane bounded cell projection organization#GO:0120036;multicellular organismal process#GO:0032501;developmental process#GO:0032502;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;Ras protein signal transduction#GO:0007265;system development#GO:0048731;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;anatomical structure development#GO:0048856;signal transduction#GO:0007165;cellular process#GO:0009987;neuron projection development#GO:0031175;nervous system development#GO:0007399;intracellular signaling cassette#GO:0141124;neuron differentiation#GO:0030182;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;signaling#GO:0023052;cell development#GO:0048468;cell projection organization#GO:0030030;response to stimulus#GO:0050896;cell differentiation#GO:0030154;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;neuron development#GO:0048666 apical part of cell#GO:0045177;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;plasma membrane region#GO:0098590;intracellular organelle#GO:0043229;endocytic vesicle#GO:0030139;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;vesicle#GO:0031982;intracellular vesicle#GO:0097708;apical plasma membrane#GO:0016324;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=37100|UniProtKB=A6NFT4 A6NFT4 CFAP73 PTHR21683:SF9 COILED-COIL DOMAIN-CONTAINING PROTEIN 42 LIKE-2-LIKE-RELATED CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 73 microtubule or microtubule-binding cytoskeletal protein#PC00157;non-motor microtubule binding protein#PC00166 HUMAN|HGNC=13397|UniProtKB=Q9UHQ9 Q9UHQ9 CYB5R1 PTHR19370:SF74 NADH-CYTOCHROME B5 REDUCTASE NADH-CYTOCHROME B5 REDUCTASE 1 nucleotide binding#GO:0000166;oxidoreductase activity#GO:0016491;heterocyclic compound binding#GO:1901363;catalytic activity#GO:0003824;oxidoreductase activity, acting on NAD(P)H#GO:0016651;flavin adenine dinucleotide binding#GO:0050660;anion binding#GO:0043168;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739 metabolite interconversion enzyme#PC00262;reductase#PC00198 HUMAN|HGNC=25118|UniProtKB=Q96BN8 Q96BN8 OTULIN PTHR33662:SF2 OTU DEUBIQUITINASE WITH LINEAR LINKAGE-SPECIFICITY A-RELATED UBIQUITIN THIOESTERASE OTULIN catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;catalytic activity#GO:0003824;cysteine-type deubiquitinase activity#GO:0004843;cysteine-type peptidase activity#GO:0008234;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005 protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;regulation of signaling#GO:0023051;regulation of inflammatory response#GO:0050727;regulation of defense response#GO:0031347;protein modification by small protein conjugation or removal#GO:0070647;regulation of cell communication#GO:0010646;negative regulation of inflammatory response#GO:0050728;negative regulation of defense response#GO:0031348;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;primary metabolic process#GO:0044238;protein modification process#GO:0036211;regulation of cytokine-mediated signaling pathway#GO:0001959;macromolecule metabolic process#GO:0043170;regulation of response to stimulus#GO:0048583;metabolic process#GO:0008152;regulation of response to stress#GO:0080134;biological regulation#GO:0065007;negative regulation of response to external stimulus#GO:0032102;regulation of signal transduction#GO:0009966;post-translational protein modification#GO:0043687;regulation of response to external stimulus#GO:0032101;negative regulation of response to stimulus#GO:0048585;cellular process#GO:0009987;regulation of response to cytokine stimulus#GO:0060759 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=1331|UniProtKB=P01031 P01031 C5 PTHR11412:SF83 MACROGLOBULIN / COMPLEMENT COMPLEMENT C5 cytokine activity#GO:0005125;cytokine receptor binding#GO:0005126;binding#GO:0005488;signaling receptor binding#GO:0005102;protein binding#GO:0005515;chemokine receptor binding#GO:0042379;molecular function activator activity#GO:0140677;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;G protein-coupled receptor binding#GO:0001664;chemokine activity#GO:0008009;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546 defense response#GO:0006952;response to external stimulus#GO:0009605;innate immune response#GO:0045087;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;adaptive immune response#GO:0002250;response to other organism#GO:0051707;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;immune response#GO:0006955;complement activation#GO:0006956;chemotaxis#GO:0006935;regulation of immune response#GO:0050776;locomotion#GO:0040011;response to external biotic stimulus#GO:0043207;regulation of immune system process#GO:0002682;immune effector process#GO:0002252;humoral immune response#GO:0006959;defense response to other organism#GO:0098542;response to chemical#GO:0042221;taxis#GO:0042330;activation of immune response#GO:0002253;positive regulation of biological process#GO:0048518;defense response to symbiont#GO:0140546;response to stress#GO:0006950;positive regulation of immune system process#GO:0002684;response to biotic stimulus#GO:0009607;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;immune system process#GO:0002376;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;regulation of biological process#GO:0050789 catalytic complex#GO:1902494;extracellular protein-containing complex#GO:0140392;extracellular region#GO:0005576;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 protease inhibitor#PC00191 HUMAN|HGNC=24291|UniProtKB=Q8IZ52 Q8IZ52 CHPF PTHR12369:SF22 CHONDROITIN SYNTHASE CHONDROITIN POLYMERIZING FACTOR, NON-CATALYTIC SUBUNIT transferase activity#GO:0016740;catalytic activity#GO:0003824;protein complex scaffold activity#GO:0140378;hexosyltransferase activity#GO:0016758;acetylgalactosaminyltransferase activity#GO:0008376;glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194;structural molecule activity#GO:0005198 proteoglycan biosynthetic process#GO:0030166;biosynthetic process#GO:0009058;chondroitin sulfate proteoglycan biosynthetic process#GO:0050650;glycoprotein biosynthetic process#GO:0009101;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;protein O-linked glycosylation#GO:0006493;macromolecule biosynthetic process#GO:0009059;chondroitin sulfate proteoglycan metabolic process#GO:0050654;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;proteoglycan metabolic process#GO:0006029;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538 glycosyltransferase#PC00111 HUMAN|HGNC=10623|UniProtKB=O00175 O00175 CCL24 PTHR12015:SF100 SMALL INDUCIBLE CYTOKINE A C-C MOTIF CHEMOKINE 24 binding#GO:0005488;cytokine receptor binding#GO:0005126;signaling receptor binding#GO:0005102;cytokine activity#GO:0005125;protein binding#GO:0005515;chemokine receptor binding#GO:0042379;molecular function activator activity#GO:0140677;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;G protein-coupled receptor binding#GO:0001664;chemokine activity#GO:0008009;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546 antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;regulation of cell motility#GO:2000145;chemokine-mediated signaling pathway#GO:0070098;cell communication#GO:0007154;cell chemotaxis#GO:0060326;cytokine-mediated signaling pathway#GO:0019221;inflammatory response#GO:0006954;chemotaxis#GO:0006935;cell motility#GO:0048870;regulation of cellular process#GO:0050794;cellular response to chemokine#GO:1990869;locomotion#GO:0040011;response to external biotic stimulus#GO:0043207;cellular response to stimulus#GO:0051716;leukocyte chemotaxis#GO:0030595;defense response#GO:0006952;response to external stimulus#GO:0009605;positive regulation of locomotion#GO:0040017;myeloid leukocyte migration#GO:0097529;leukocyte migration#GO:0050900;regulation of cell migration#GO:0030334;cell migration#GO:0016477;regulation of locomotion#GO:0040012;response to other organism#GO:0051707;biological regulation#GO:0065007;positive regulation of cell migration#GO:0030335;positive regulation of cellular process#GO:0048522;immune response#GO:0006955;response to peptide#GO:1901652;immune system process#GO:0002376;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;granulocyte chemotaxis#GO:0071621;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052;positive regulation of cell motility#GO:2000147;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;antimicrobial humoral response#GO:0019730;humoral immune response#GO:0006959;cell surface receptor signaling pathway#GO:0007166;granulocyte migration#GO:0097530;defense response to other organism#GO:0098542;taxis#GO:0042330;response to chemical#GO:0042221;response to cytokine#GO:0034097;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;response to chemokine#GO:1990868;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;defense response to symbiont#GO:0140546 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 cytokine#PC00083 HUMAN|HGNC=25717|UniProtKB=Q9H857 Q9H857 NT5DC2 PTHR12103:SF14 5'-NUCLEOTIDASE DOMAIN-CONTAINING 5'-NUCLEOTIDASE DOMAIN-CONTAINING PROTEIN 2 hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 hydrolase#PC00121;nucleotide phosphatase#PC00173;phosphatase#PC00181 HUMAN|HGNC=26404|UniProtKB=Q4G0N4 Q4G0N4 NADK2 PTHR13158:SF5 FAMILY NOT NAMED NAD KINASE 2, MITOCHONDRIAL kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;phosphotransferase activity, alcohol group as acceptor#GO:0016773 nucleotide metabolic process#GO:0009117;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;pyridine-containing compound metabolic process#GO:0072524;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;NAD+ metabolic process#GO:0019674;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;nicotinamide nucleotide metabolic process#GO:0046496 HUMAN|HGNC=2992|UniProtKB=O77932 O77932 DXO PTHR12395:SF9 DOM-3 RELATED DECAPPING AND EXORIBONUCLEASE PROTEIN hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity, acting on RNA#GO:0140098;phosphoric ester hydrolase activity#GO:0042578;phosphatase activity#GO:0016791;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on a nucleic acid#GO:0140640;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824 RNA decapping#GO:0110154;RNA metabolic process#GO:0016070;RNA catabolic process#GO:0006401;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;negative regulation of biological process#GO:0048519;regulation of gene expression#GO:0010468;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;macromolecule catabolic process#GO:0009057;negative regulation of cellular process#GO:0048523;metabolic process#GO:0008152;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;cellular process#GO:0009987;nucleic acid catabolic process#GO:0141188;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleobase-containing compound catabolic process#GO:0034655 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=30904|UniProtKB=O60763 O60763 USO1 PTHR10013:SF7 GENERAL VESICULAR TRANSPORT FACTOR P115 GENERAL VESICULAR TRANSPORT FACTOR P115 intracellular transport#GO:0046907;transport#GO:0006810;Golgi vesicle transport#GO:0048193;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular component organization#GO:0016043;membrane fusion#GO:0061025;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;multicellular organismal process#GO:0032501;vesicle-mediated transport#GO:0016192;membrane organization#GO:0061024 intracellular organelle#GO:0043229;COPII-coated ER to Golgi transport vesicle#GO:0030134;intracellular anatomical structure#GO:0005622;coated vesicle#GO:0030135;cytoplasmic vesicle#GO:0031410;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular vesicle#GO:0097708;Golgi stack#GO:0005795;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;coated vesicle membrane#GO:0030662;Golgi apparatus#GO:0005794;endoplasmic reticulum#GO:0005783;ER to Golgi transport vesicle membrane#GO:0012507;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;vesicle membrane#GO:0012506;endomembrane system#GO:0012505;transport vesicle membrane#GO:0030658;cytoplasmic vesicle membrane#GO:0030659;transport vesicle#GO:0030133;cytoplasm#GO:0005737 membrane traffic protein#PC00150 HUMAN|HGNC=16875|UniProtKB=Q9UBG0 Q9UBG0 MRC2 PTHR22803:SF69 MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED C-TYPE MANNOSE RECEPTOR 2 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 receptor-mediated endocytosis#GO:0006898;localization#GO:0051179;import into cell#GO:0098657;establishment of localization#GO:0051234;transport#GO:0006810;endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=12661|UniProtKB=Q9UIW0 Q9UIW0 VAX2 PTHR24339:SF34 HOMEOBOX PROTEIN EMX-RELATED VENTRAL ANTERIOR HOMEOBOX 2 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;central nervous system development#GO:0007417;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;nervous system development#GO:0007399;head development#GO:0060322;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;brain development#GO:0007420;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;animal organ development#GO:0048513;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;neuron differentiation#GO:0030182;developmental process#GO:0032502 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 homeodomain transcription factor#PC00119 HUMAN|HGNC=14917|UniProtKB=Q9NYW1 Q9NYW1 TAS2R9 PTHR11394:SF29 TASTE RECEPTOR TYPE 2 TASTE RECEPTOR TYPE 2 MEMBER 9 transmembrane signaling receptor activity#GO:0004888;taste receptor activity#GO:0008527;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;bitter taste receptor activity#GO:0033038 detection of chemical stimulus involved in sensory perception of bitter taste#GO:0001580;system process#GO:0003008;sensory perception of taste#GO:0050909;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception#GO:0007600;nervous system process#GO:0050877;detection of chemical stimulus involved in sensory perception of taste#GO:0050912;response to chemical#GO:0042221;response to stimulus#GO:0050896;multicellular organismal process#GO:0032501;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;detection of chemical stimulus#GO:0009593;sensory perception of bitter taste#GO:0050913 membrane#GO:0016020;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=33437|UniProtKB=P0CG30 P0CG30 GSTT2B PTHR43917:SF4 FAMILY NOT NAMED GLUTATHIONE S-TRANSFERASE THETA-2-RELATED transferase activity#GO:0016740;catalytic activity#GO:0003824;glutathione transferase activity#GO:0004364;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765 cellular process#GO:0009987;glutathione metabolic process#GO:0006749;sulfur compound metabolic process#GO:0006790;modified amino acid metabolic process#GO:0006575;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 transferase#PC00220 HUMAN|HGNC=23535|UniProtKB=Q96MN9 Q96MN9 ZNF488 PTHR16516:SF5 AGAP007109-PA ZINC FINGER PROTEIN 488 regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=24887|UniProtKB=P41247 P41247 PNPLA4 PTHR12406:SF48 CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 IPLA2 -RELATED PATATIN-LIKE PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN 4 transferase activity#GO:0016740;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;triacylglycerol lipase activity#GO:0004806;acyltransferase activity#GO:0016746;lipase activity#GO:0016298;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity#GO:0016787 glycerolipid catabolic process#GO:0046503;triglyceride catabolic process#GO:0019433;lipid homeostasis#GO:0055088;primary metabolic process#GO:0044238;glycerolipid metabolic process#GO:0046486;catabolic process#GO:0009056;homeostatic process#GO:0042592;acylglycerol metabolic process#GO:0006639;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;triglyceride metabolic process#GO:0006641;chemical homeostasis#GO:0048878;neutral lipid catabolic process#GO:0046461;neutral lipid metabolic process#GO:0006638;acylglycerol catabolic process#GO:0046464;cellular process#GO:0009987;lipid catabolic process#GO:0016042 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739 phospholipase#PC00186 HUMAN|HGNC=4508|UniProtKB=Q9Y2T5 Q9Y2T5 GPR52 PTHR24240:SF225 OPSIN G PROTEIN-COUPLED RECEPTOR 52 transmembrane signaling receptor activity#GO:0004888;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cellular response to abiotic stimulus#GO:0071214;response to external stimulus#GO:0009605;biological regulation#GO:0065007;detection of stimulus#GO:0051606;signal transduction#GO:0007165;cellular process#GO:0009987;response to radiation#GO:0009314;cellular response to light stimulus#GO:0071482;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;response to stimulus#GO:0050896;response to light stimulus#GO:0009416;cellular response to environmental stimulus#GO:0104004;regulation of cellular process#GO:0050794;signaling#GO:0023052;cellular response to radiation#GO:0071478;response to abiotic stimulus#GO:0009628;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HUMAN|HGNC=6547|UniProtKB=P01130 P01130 LDLR PTHR24270:SF21 LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED LOW-DENSITY LIPOPROTEIN RECEPTOR cargo receptor activity#GO:0038024;low-density lipoprotein particle receptor activity#GO:0005041 intracellular transport#GO:0046907;transport#GO:0006810;chemical homeostasis#GO:0048878;import into cell#GO:0098657;sterol transport#GO:0015918;cholesterol homeostasis#GO:0042632;establishment of localization#GO:0051234;receptor-mediated endocytosis#GO:0006898;macromolecule localization#GO:0033036;cholesterol transport#GO:0030301;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;lipid transport#GO:0006869;vesicle-mediated transport#GO:0016192;lipid localization#GO:0010876;localization#GO:0051179;cellular localization#GO:0051641;organic hydroxy compound transport#GO:0015850;lipid homeostasis#GO:0055088;endocytosis#GO:0006897;homeostatic process#GO:0042592;intracellular sterol transport#GO:0032366 plasma membrane#GO:0005886;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cell periphery#GO:0071944;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;early endosome#GO:0005769;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708 apolipoprotein#PC00052;transfer/carrier protein#PC00219 HUMAN|HGNC=9165|UniProtKB=O43236 O43236 SEPTIN4 PTHR37884:SF1 SEPTIN 4 SEPTIN-4 Parkinson disease#P00049>CDCrel-1#P01226 HUMAN|HGNC=26449|UniProtKB=Q96N58 Q96N58 ZNF578 PTHR24377:SF859 IP01015P-RELATED ZINC FINGER PROTEIN 578 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=24809|UniProtKB=Q9Y2M2 Q9Y2M2 SSUH2 PTHR48465:SF1 PROTEIN SSUH2 HOMOLOG PROTEIN SSUH2 HOMOLOG HUMAN|HGNC=31949|UniProtKB=A8MTB9 A8MTB9 CEACAM18 PTHR44337:SF10 CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 8 CELL ADHESION MOLECULE CEACAM18 cell-cell adhesion#GO:0098609;homophilic cell-cell adhesion#GO:0007156;heterophilic cell-cell adhesion#GO:0007157;cellular process#GO:0009987;cell adhesion#GO:0007155 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 immunoglobulin superfamily cell adhesion molecule#PC00125;cell adhesion molecule#PC00069 HUMAN|HGNC=21218|UniProtKB=O43598 O43598 DNPH1 PTHR15364:SF0 2'-DEOXYNUCLEOSIDE 5'-PHOSPHATE N-HYDROLASE 1 5-HYDROXYMETHYL-DUMP N-HYDROLASE catalytic activity#GO:0003824;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787 nucleoside phosphate catabolic process#GO:1901292;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;nucleoside phosphate metabolic process#GO:0006753;nucleoside monophosphate metabolic process#GO:0009123;nucleobase-containing compound metabolic process#GO:0006139;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;nucleobase-containing compound catabolic process#GO:0034655;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;organophosphate catabolic process#GO:0046434;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 hydrolase#PC00121 HUMAN|HGNC=411|UniProtKB=P48448 P48448 ALDH3B2 PTHR43570:SF6 ALDEHYDE DEHYDROGENASE ALDEHYDE DEHYDROGENASE FAMILY 3 MEMBER B2 oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor#GO:0016620;aldehyde dehydrogenase (NAD+) activity#GO:0004029;oxidoreductase activity, acting on the aldehyde or oxo group of donors#GO:0016903;catalytic activity#GO:0003824 aldehyde metabolic process#GO:0006081;cellular process#GO:0009987;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 dehydrogenase#PC00092 5-Hydroxytryptamine degredation#P04372>Aldehyde Dehydrogenase#P04402 HUMAN|HGNC=3434|UniProtKB=P18074 P18074 ERCC2 PTHR11472:SF1 DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;damaged DNA binding#GO:0003684;macromolecular conformation isomerase activity#GO:0120543;helicase activity#GO:0004386;catalytic activity, acting on DNA#GO:0140097;DNA helicase activity#GO:0003678;isomerase activity#GO:0016853;binding#GO:0005488;nucleic acid binding#GO:0003676;ATP-dependent activity#GO:0140657;ATP-dependent activity, acting on DNA#GO:0008094;DNA binding#GO:0003677 response to stress#GO:0006950;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;nucleotide-excision repair#GO:0006289;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;nucleobase-containing compound biosynthetic process#GO:0034654;transcription by RNA polymerase II#GO:0006366;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;nucleic acid biosynthetic process#GO:0141187;cellular response to stress#GO:0033554;RNA metabolic process#GO:0016070 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA helicase#PC00011;DNA metabolism protein#PC00009 HUMAN|HGNC=28383|UniProtKB=Q8N7B1 Q8N7B1 HORMAD2 PTHR48225:SF6 HORMA DOMAIN-CONTAINING PROTEIN 1 HORMA DOMAIN-CONTAINING PROTEIN 2 meiotic chromosome segregation#GO:0045132;chromosome organization#GO:0051276;meiotic nuclear division#GO:0140013;negative regulation of cell cycle process#GO:0010948;negative regulation of cellular process#GO:0048523;regulation of nuclear division#GO:0051783;negative regulation of nuclear division#GO:0051784;biological regulation#GO:0065007;regulation of reproductive process#GO:2000241;intracellular signal transduction#GO:0035556;organelle fission#GO:0048285;cell communication#GO:0007154;sexual reproduction#GO:0019953;meiosis I cell cycle process#GO:0061982;reproductive process#GO:0022414;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;negative regulation of organelle organization#GO:0010639;negative regulation of cellular component organization#GO:0051129;regulation of cell cycle phase transition#GO:1901987;cell cycle#GO:0007049;negative regulation of cell cycle#GO:0045786;cellular component organization or biogenesis#GO:0071840;homologous chromosome segregation#GO:0045143;chromosome segregation#GO:0007059;chromosome organization involved in meiotic cell cycle#GO:0070192;meiotic cell cycle#GO:0051321;homologous chromosome pairing at meiosis#GO:0007129;regulation of cell cycle process#GO:0010564;synaptonemal complex assembly#GO:0007130;cellular component assembly#GO:0022607;cell cycle checkpoint signaling#GO:0000075;cellular process#GO:0009987;signal transduction#GO:0007165;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;nuclear division#GO:0000280;regulation of cell cycle#GO:0051726;signaling#GO:0023052;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;regulation of organelle organization#GO:0033043;cell cycle process#GO:0022402;regulation of meiotic cell cycle#GO:0051445;regulation of biological process#GO:0050789;meiotic cell cycle process#GO:1903046;nuclear chromosome segregation#GO:0098813;meiosis I#GO:0007127;negative regulation of cell cycle phase transition#GO:1901988;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519 chromosome#GO:0005694;organelle lumen#GO:0043233;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;synaptonemal structure#GO:0099086;condensed chromosome#GO:0000793;synaptonemal complex#GO:0000795;condensed nuclear chromosome#GO:0000794;membraneless organelle#GO:0043228 HUMAN|HGNC=12867|UniProtKB=Q9Y2L8 Q9Y2L8 ZKSCAN5 PTHR24377:SF214 IP01015P-RELATED ZINC FINGER PROTEIN WITH KRAB AND SCAN DOMAINS 5 DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=2073|UniProtKB=O14773 O14773 TPP1 PTHR14218:SF41 PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2 TRIPEPTIDYL-PEPTIDASE 1 catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;serine-type peptidase activity#GO:0008236;exopeptidase activity#GO:0008238;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171 nervous system development#GO:0007399;multicellular organismal process#GO:0032501;cellular process#GO:0009987;multicellular organism development#GO:0007275;macromolecule metabolic process#GO:0043170;developmental process#GO:0032502;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;catabolic process#GO:0009056;central nervous system development#GO:0007417;primary metabolic process#GO:0044238;system development#GO:0048731;protein metabolic process#GO:0019538;anatomical structure development#GO:0048856;protein catabolic process in the vacuole#GO:0007039;protein catabolic process#GO:0030163;animal gross anatomical part developmental process#GO:0160108;proteolysis#GO:0006508 lysosome#GO:0005764;vacuole#GO:0005773;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;lytic vacuole#GO:0000323 serine protease#PC00203 HUMAN|HGNC=4921|UniProtKB=P31629 P31629 HIVEP2 PTHR45944:SF1 SCHNURRI, ISOFORM F TRANSCRIPTION FACTOR HIVEP2 DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=270|UniProtKB=P09874 P09874 PARP1 PTHR10459:SF112 DNA LIGASE POLY [ADP-RIBOSE] POLYMERASE 1 catalytic activity#GO:0003824;transferase activity#GO:0016740;NAD+ poly-ADP-ribosyltransferase activity#GO:0003950;pentosyltransferase activity#GO:0016763;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757 response to stress#GO:0006950;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;double-strand break repair#GO:0006302 organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 DNA metabolism protein#PC00009 FAS signaling pathway#P00020>PARP#P00600 HUMAN|HGNC=2767|UniProtKB=O15263 O15263 DEFB4A PTHR20515:SF2 BETA-DEFENSIN DEFENSIN BETA 4A binding#GO:0005488;cytokine receptor binding#GO:0005126;signaling receptor binding#GO:0005102;molecular function activator activity#GO:0140677;chemokine receptor binding#GO:0042379;protein binding#GO:0005515;G protein-coupled receptor binding#GO:0001664;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546 cellular process#GO:0009987;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;response to other organism#GO:0051707;taxis#GO:0042330;response to chemical#GO:0042221;cell migration#GO:0016477;response to external stimulus#GO:0009605;defense response#GO:0006952;cellular response to stimulus#GO:0051716;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;locomotion#GO:0040011;response to stimulus#GO:0050896;cell motility#GO:0048870;defense response to bacterium#GO:0042742;chemotaxis#GO:0006935;cellular response to chemical stimulus#GO:0070887;response to bacterium#GO:0009617;cell chemotaxis#GO:0060326 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090;antimicrobial response protein#PC00051 HUMAN|HGNC=13307|UniProtKB=Q9H1C0 Q9H1C0 LPAR5 PTHR24234:SF6 LYSOPHOSPHATIDIC ACID RECEPTOR 5/SPHINGOSYLPHOSPHORYLCHOLINE RECEPTOR LYSOPHOSPHATIDIC ACID RECEPTOR 5 response to stress#GO:0006950;multicellular organismal process#GO:0032501;response to stimulus#GO:0050896 G-protein coupled receptor#PC00021 HUMAN|HGNC=2720|UniProtKB=Q9ULH1 Q9ULH1 ASAP1 PTHR45854:SF2 ASAP FAMILY MEMBER ARF-GAP WITH SH3 DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 1 GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme activator activity#GO:0008047 cilium assembly#GO:0060271;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of cellular component organization#GO:0051128;cell projection organization#GO:0030030;regulation of cellular process#GO:0050794;organelle assembly#GO:0070925;positive regulation of cellular component organization#GO:0051130;cilium organization#GO:0044782;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cell projection assembly#GO:0030031;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;cellular component assembly#GO:0022607;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;plasma membrane bounded cell projection assembly#GO:0120031;cellular component organization or biogenesis#GO:0071840 intracellular organelle#GO:0043229;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;actin cytoskeleton#GO:0015629;actin-based cell projection#GO:0098858;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;organelle membrane#GO:0031090;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;cell periphery#GO:0071944;trans-Golgi network membrane#GO:0032588;endomembrane system#GO:0012505;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802 Integrin signalling pathway#P00034>ASAP1#P00909 HUMAN|HGNC=16|UniProtKB=P01011 P01011 SERPINA3 PTHR11461:SF392 SERINE PROTEASE INHIBITOR, SERPIN ALPHA-1-ANTICHYMOTRYPSIN molecular function inhibitor activity#GO:0140678;serine-type endopeptidase inhibitor activity#GO:0004867;enzyme regulator activity#GO:0030234;peptidase regulator activity#GO:0061134;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414;molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866;enzyme inhibitor activity#GO:0004857 response to peptide#GO:1901652;response to cytokine#GO:0034097;response to stimulus#GO:0050896;response to chemical#GO:0042221 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease inhibitor#PC00191 HUMAN|HGNC=1258|UniProtKB=Q9NVD3 Q9NVD3 SETD4 PTHR13271:SF164 UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE SET DOMAIN-CONTAINING PROTEIN 4 S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;N-methyltransferase activity#GO:0008170;histone methyltransferase activity#GO:0042054;protein-lysine N-methyltransferase activity#GO:0016279;histone modifying activity#GO:0140993;histone H3 methyltransferase activity#GO:0140938;histone H3K4 methyltransferase activity#GO:0042800;lysine N-methyltransferase activity#GO:0016278;transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein methyltransferase activity#GO:0008276;catalytic activity, acting on a protein#GO:0140096 cellular component organization#GO:0016043;regulation of biological process#GO:0050789;chromatin remodeling#GO:0006338;regulation of inflammatory response#GO:0050727;regulation of defense response#GO:0031347;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;regulation of response to external stimulus#GO:0032101;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;chromatin organization#GO:0006325;positive regulation of inflammatory response#GO:0050729;regulation of response to stress#GO:0080134;regulation of response to stimulus#GO:0048583;positive regulation of defense response#GO:0031349;positive regulation of response to external stimulus#GO:0032103;cellular component organization or biogenesis#GO:0071840 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cytosol#GO:0005829;nucleus#GO:0005634 methyltransferase#PC00155;transferase#PC00220 HUMAN|HGNC=20645|UniProtKB=Q9BWM5 Q9BWM5 ZNF416 PTHR24377:SF724 IP01015P-RELATED ZINC FINGER PROTEIN 416 double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=33719|UniProtKB=Q5SNT2 Q5SNT2 TMEM201 PTHR28646:SF1 TRANSMEMBRANE PROTEIN 201 TRANSMEMBRANE PROTEIN 201 protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;actin filament binding#GO:0051015;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092 anatomical structure morphogenesis#GO:0009653;nuclear migration#GO:0007097;blood vessel development#GO:0001568;tube morphogenesis#GO:0035239;blood vessel morphogenesis#GO:0048514;circulatory system development#GO:0072359;microtubule-based movement#GO:0007018;establishment of organelle localization#GO:0051656;microtubule-based transport#GO:0099111;animal gross anatomical part developmental process#GO:0160108;organelle localization#GO:0051640;system development#GO:0048731;localization#GO:0051179;angiogenesis#GO:0001525;anatomical structure development#GO:0048856;cellular localization#GO:0051641;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;tube development#GO:0035295;organelle transport along microtubule#GO:0072384;multicellular organismal process#GO:0032501;cytoskeleton-dependent intracellular transport#GO:0030705;developmental process#GO:0032502;transport#GO:0006810;intracellular transport#GO:0046907;vasculature development#GO:0001944;microtubule-based process#GO:0007017;anatomical structure formation involved in morphogenesis#GO:0048646;multicellular organism development#GO:0007275;transport along microtubule#GO:0010970;establishment of localization#GO:0051234 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;membrane#GO:0016020;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;nuclear membrane#GO:0031965;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=19918|UniProtKB=Q6NSJ0 Q6NSJ0 MYORG PTHR43053:SF8 GLYCOSIDASE FAMILY 31 ALPHA-GALACTOSIDASE MYORG skeletal muscle organ development#GO:0060538;animal gross anatomical part developmental process#GO:0160108;striated muscle cell development#GO:0055002;anatomical structure development#GO:0048856;muscle tissue development#GO:0060537;muscle cell development#GO:0055001;muscle cell differentiation#GO:0042692;cell differentiation#GO:0030154;muscle structure development#GO:0061061;cell development#GO:0048468;muscle organ development#GO:0007517;developmental process#GO:0032502;striated muscle tissue development#GO:0014706;animal organ development#GO:0048513;cellular developmental process#GO:0048869;striated muscle cell differentiation#GO:0051146;cellular process#GO:0009987;skeletal muscle tissue development#GO:0007519;tissue development#GO:0009888 metabolite interconversion enzyme#PC00262;glucosidase#PC00108;hydrolase#PC00121 HUMAN|HGNC=8537|UniProtKB=Q99572 Q99572 P2RX7 PTHR10125:SF13 P2X PURINOCEPTOR P2X PURINOCEPTOR 7 monoatomic ion channel activity#GO:0005216;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;ligand-gated monoatomic cation channel activity#GO:0099094;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;gated channel activity#GO:0022836;ligand-gated monoatomic ion channel activity#GO:0015276 signal transduction#GO:0007165;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;cell surface receptor signaling pathway#GO:0007166;transport#GO:0006810;calcium ion transport#GO:0006816;establishment of localization#GO:0051234;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;calcium ion transmembrane transport#GO:0070588;metal ion transport#GO:0030001;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;cell communication#GO:0007154;transmembrane transport#GO:0055085 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 ligand-gated ion channel#PC00141 HUMAN|HGNC=37276|UniProtKB=A4D126 A4D126 CRPPA PTHR43015:SF1 D-RIBITOL-5-PHOSPHATE CYTIDYLYLTRANSFERASE D-RIBITOL-5-PHOSPHATE CYTIDYLYLTRANSFERASE transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;nucleotidyltransferase activity#GO:0016779 biosynthetic process#GO:0009058;protein O-linked glycosylation#GO:0006493;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;protein O-linked glycosylation via mannose#GO:0035269;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 transferase#PC00220 HUMAN|HGNC=31136|UniProtKB=Q4VC31 Q4VC31 MIX23 PTHR31905:SF4 COILED-COIL DOMAIN-CONTAINING PROTEIN 58 PROTEIN MIX23 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HUMAN|HGNC=8179|UniProtKB=Q9P1Q5 Q9P1Q5 OR1A1 PTHR48001:SF50 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 1A1-RELATED transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cell communication#GO:0007154 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=30859|UniProtKB=O75643 O75643 SNRNP200 PTHR24075:SF13 SEC63 DOMAIN-CONTAINING U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 200 KDA HELICASE macromolecular conformation isomerase activity#GO:0120543;catalytic activity, acting on a nucleic acid#GO:0140640;RNA helicase activity#GO:0003724;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity#GO:0003824;isomerase activity#GO:0016853;catalytic activity, acting on RNA#GO:0140098;helicase activity#GO:0004386;ATP-dependent activity#GO:0140657;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 protein-containing complex assembly#GO:0065003;mRNA splicing, via spliceosome#GO:0000398;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA metabolic process#GO:0016070;protein-RNA complex assembly#GO:0022618;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;cellular component biogenesis#GO:0044085;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;cellular component assembly#GO:0022607;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;protein-containing complex organization#GO:0043933;protein-RNA complex organization#GO:0071826;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170 nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;spliceosomal complex#GO:0005681;nucleus#GO:0005634 scaffold/adaptor protein#PC00226 HUMAN|HGNC=18123|UniProtKB=Q8NER5 Q8NER5 ACVR1C PTHR23255:SF58 TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II ACTIVIN RECEPTOR TYPE-1C molecular transducer activity#GO:0060089;catalytic activity, acting on a protein#GO:0140096;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein serine/threonine kinase activity#GO:0004675;protein-containing complex binding#GO:0044877;protein kinase activity#GO:0004672;binding#GO:0005488;protein serine/threonine kinase activity#GO:0004674;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;transferase activity#GO:0016740;kinase activity#GO:0016301;activin binding#GO:0048185 multicellular organism development#GO:0007275;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;cell surface receptor signaling pathway#GO:0007166;developmental process#GO:0032502;multicellular organismal process#GO:0032501;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;nervous system development#GO:0007399;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;system development#GO:0048731;cellular response to growth factor stimulus#GO:0071363;animal gross anatomical part developmental process#GO:0160108;activin receptor signaling pathway#GO:0032924;regulation of cellular process#GO:0050794;response to growth factor#GO:0070848;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;signaling#GO:0023052;response to endogenous stimulus#GO:0009719;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789 protein kinase complex#GO:1902911;serine/threonine protein kinase complex#GO:1902554;transferase complex, transferring phosphorus-containing groups#GO:0061695;signaling receptor complex#GO:0043235;catalytic complex#GO:1902494;transferase complex#GO:1990234;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797 serine/threonine protein kinase receptor#PC00205 Wnt signaling pathway#P00057>TGFbetaactivated Kinase-1#P01442;TGF-beta signaling pathway#P00052>TGFbetareceptor I#P01278;TGF-beta signaling pathway#P00052>TGFbetareceptors#P01283 HUMAN|HGNC=16760|UniProtKB=Q9H9Q2 Q9H9Q2 COPS7B PTHR15350:SF8 COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17 COP9 SIGNALOSOME COMPLEX SUBUNIT 7B protein modification process#GO:0036211;primary metabolic process#GO:0044238;cellular process#GO:0009987;post-translational protein modification#GO:0043687;protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;COP9 signalosome#GO:0008180;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634 HUMAN|HGNC=23233|UniProtKB=Q8N428 Q8N428 GALNT16 PTHR11675:SF3 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 16 acetylgalactosaminyltransferase activity#GO:0008376;glycosyltransferase activity#GO:0016757;catalytic activity, acting on a protein#GO:0140096;UDP-glycosyltransferase activity#GO:0008194;transferase activity#GO:0016740;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;polypeptide N-acetylgalactosaminyltransferase activity#GO:0004653 protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;biosynthetic process#GO:0009058;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein O-linked glycosylation#GO:0006493;carbohydrate derivative metabolic process#GO:1901135;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 transferase#PC00220;glycosyltransferase#PC00111 HUMAN|HGNC=26288|UniProtKB=Q6NUN7 Q6NUN7 JHY PTHR14726:SF1 JHY PROTEIN HOMOLOG JHY PROTEIN HOMOLOG plasma membrane bounded cell projection assembly#GO:0120031;developmental process#GO:0032502;animal organ development#GO:0048513;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cell projection assembly#GO:0030031;multicellular organismal process#GO:0032501;brain development#GO:0007420;cellular component assembly#GO:0022607;nervous system development#GO:0007399;head development#GO:0060322;plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton organization#GO:0007010;animal gross anatomical part developmental process#GO:0160108;organelle assembly#GO:0070925;microtubule bundle formation#GO:0001578;anatomical structure development#GO:0048856;microtubule cytoskeleton organization#GO:0000226;cilium organization#GO:0044782;system development#GO:0048731;axoneme assembly#GO:0035082;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cell projection organization#GO:0030030;central nervous system development#GO:0007417 HUMAN|HGNC=11292|UniProtKB=P30626 P30626 SRI PTHR46735:SF7 CALPAIN, SMALL SUBUNIT 1 A-RELATED SORCIN calcium ion binding#GO:0005509;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;cation binding#GO:0043169;metal ion binding#GO:0046872 HUMAN|HGNC=3293|UniProtKB=O60573 O60573 EIF4E2 PTHR11960:SF17 EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TYPE 2 translation factor activity#GO:0180051;binding#GO:0005488;nucleic acid binding#GO:0003676;translation initiation factor activity#GO:0003743;RNA binding#GO:0003723 biosynthetic process#GO:0009058;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;translational initiation#GO:0006413;translation#GO:0006412;metabolic process#GO:0008152 intracellular protein-containing complex#GO:0140535;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 translational protein#PC00263;translation factor#PC00223;translation initiation factor#PC00224 HUMAN|HGNC=18531|UniProtKB=Q96NW7 Q96NW7 LRRC7 PTHR23119:SF48 DISCS LARGE LEUCINE-RICH REPEAT-CONTAINING PROTEIN 7 kinase binding#GO:0019900;binding#GO:0005488;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;protein binding#GO:0005515 cell-cell adhesion#GO:0098609;macromolecule localization#GO:0033036;cellular process#GO:0009987;regulation of neuron projection development#GO:0010975;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;biological regulation#GO:0065007;regulation of cell projection organization#GO:0031344;regulation of plasma membrane bounded cell projection organization#GO:0120035;intracellular protein localization#GO:0008104;protein localization to membrane#GO:0072657;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;establishment or maintenance of apical/basal cell polarity#GO:0035088;establishment or maintenance of cell polarity#GO:0007163;positive regulation of neuron projection development#GO:0010976;positive regulation of cell projection organization#GO:0031346;establishment or maintenance of bipolar cell polarity#GO:0061245;receptor clustering#GO:0043113;cell adhesion#GO:0007155;positive regulation of cellular component organization#GO:0051130;localization within membrane#GO:0051668;cellular localization#GO:0051641;establishment or maintenance of epithelial cell apical/basal polarity#GO:0045197;localization#GO:0051179 plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;neuron projection#GO:0043005;main axon#GO:0044304;cell-cell junction#GO:0005911;anchoring junction#GO:0070161;adherens junction#GO:0005912;cell junction#GO:0030054;axon#GO:0030424 scaffold/adaptor protein#PC00226 HUMAN|HGNC=24781|UniProtKB=Q6ZTR7 Q6ZTR7 CIBAR2 PTHR21223:SF3 CBY1-INTERACTING BAR DOMAIN-CONTAINING PROTEIN HOMOLOG CBY1-INTERACTING BAR DOMAIN-CONTAINING PROTEIN 2 cilium organization#GO:0044782;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection assembly#GO:0120031;organelle assembly#GO:0070925;plasma membrane bounded cell projection organization#GO:0120036;cell projection organization#GO:0030030;cellular component assembly#GO:0022607;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cilium#GO:0005929;microtubule organizing center#GO:0005815;ciliary basal body#GO:0036064;ciliary transition zone#GO:0035869;cytoskeleton#GO:0005856;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microtubule cytoskeleton#GO:0015630 HUMAN|HGNC=8877|UniProtKB=P08237 P08237 PFKM PTHR13697:SF59 PHOSPHOFRUCTOKINASE ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE, MUSCLE TYPE phosphotransferase activity, alcohol group as acceptor#GO:0016773;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;anion binding#GO:0043168;carbohydrate derivative binding#GO:0097367;carbohydrate kinase activity#GO:0019200;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 cellular process#GO:0009987;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;nicotinamide nucleotide metabolic process#GO:0046496;purine ribonucleotide metabolic process#GO:0009150;monosaccharide metabolic process#GO:0005996;metabolic process#GO:0008152;ADP catabolic process#GO:0046032;glucose metabolic process#GO:0006006;purine-containing compound catabolic process#GO:0072523;purine nucleoside diphosphate catabolic process#GO:0009137;nucleobase-containing small molecule metabolic process#GO:0055086;phosphorus metabolic process#GO:0006793;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;ribonucleoside diphosphate metabolic process#GO:0009185;pyridine-containing compound catabolic process#GO:0072526;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;small molecule metabolic process#GO:0044281;small molecule catabolic process#GO:0044282;pyruvate metabolic process#GO:0006090;pyridine nucleotide catabolic process#GO:0019364;ribonucleotide metabolic process#GO:0009259;purine nucleoside diphosphate metabolic process#GO:0009135;oxoacid metabolic process#GO:0043436;carbohydrate catabolic process#GO:0016052;nucleotide metabolic process#GO:0009117;organophosphate metabolic process#GO:0019637;nucleobase-containing compound catabolic process#GO:0034655;glycolytic process#GO:0006096;purine ribonucleoside triphosphate metabolic process#GO:0009205;ribonucleotide catabolic process#GO:0009261;carbohydrate derivative metabolic process#GO:1901135;nucleobase-containing compound metabolic process#GO:0006139;nucleotide catabolic process#GO:0009166;purine ribonucleoside diphosphate metabolic process#GO:0009179;generation of precursor metabolites and energy#GO:0006091;energy derivation by oxidation of organic compounds#GO:0015980;ADP metabolic process#GO:0046031;primary metabolic process#GO:0044238;hexose metabolic process#GO:0019318;nucleoside diphosphate catabolic process#GO:0009134;purine nucleoside triphosphate metabolic process#GO:0009144;purine ribonucleotide catabolic process#GO:0009154;nucleoside phosphate catabolic process#GO:1901292;catabolic process#GO:0009056;carbohydrate derivative catabolic process#GO:1901136;nucleoside triphosphate metabolic process#GO:0009141;nucleoside phosphate metabolic process#GO:0006753;carbohydrate metabolic process#GO:0005975;nucleoside diphosphate metabolic process#GO:0009132;pyridine-containing compound metabolic process#GO:0072524;purine nucleotide catabolic process#GO:0006195;cellular respiration#GO:0045333;ribonucleoside diphosphate catabolic process#GO:0009191;organophosphate catabolic process#GO:0046434;aerobic respiration#GO:0009060;purine ribonucleoside diphosphate catabolic process#GO:0009181 intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;transferase complex#GO:1990234;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;cytosol#GO:0005829;membrane#GO:0016020 transferase#PC00220;carbohydrate kinase#PC00065;kinase#PC00137 Glycolysis#P00024>Phosphofructokinase-1#P00672 HUMAN|HGNC=11447|UniProtKB=Q8WUJ0 Q8WUJ0 STYX PTHR46588:SF1 SERINE/THREONINE/TYROSINE-INTERACTING PROTEIN SERINE_THREONINE_TYROSINE-INTERACTING PROTEIN regulation of protein catabolic process#GO:0042176;negative regulation of catabolic process#GO:0009895;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;regulation of cell communication#GO:0010646;negative regulation of protein metabolic process#GO:0051248;negative regulation of metabolic process#GO:0009892;negative regulation of proteasomal protein catabolic process#GO:1901799;regulation of cellular process#GO:0050794;negative regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032435;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of ubiquitin-dependent protein catabolic process#GO:2000059;regulation of catabolic process#GO:0009894;regulation of response to stimulus#GO:0048583;regulation of MAPK cascade#GO:0043408;negative regulation of cellular process#GO:0048523;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of ERK1 and ERK2 cascade#GO:0070372;regulation of proteasomal protein catabolic process#GO:0061136;negative regulation of protein catabolic process#GO:0042177;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;regulation of primary metabolic process#GO:0080090 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 Oxidative stress response#P00046>MKP5#P01131 HUMAN|HGNC=25968|UniProtKB=Q9NXL2 Q9NXL2 ARHGEF38 PTHR22834:SF17 NUCLEAR FUSION PROTEIN FUS2 RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 38 guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=23296|UniProtKB=Q96KN9 Q96KN9 GJD4 PTHR11984:SF3 CONNEXIN GAP JUNCTION DELTA-4 PROTEIN wide pore channel activity#GO:0022829;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 cell communication#GO:0007154;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;signaling#GO:0023052;regulation of biological process#GO:0050789;cellular process#GO:0009987 anchoring junction#GO:0070161;cell junction#GO:0030054;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane#GO:0016020;cell-cell junction#GO:0005911;membrane protein complex#GO:0098796;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 cell junction protein#PC00070;gap junction#PC00105 HUMAN|HGNC=16500|UniProtKB=Q9UN19 Q9UN19 DAPP1 PTHR14336:SF15 TANDEM PH DOMAIN CONTAINING PROTEIN DUAL ADAPTER FOR PHOSPHOTYROSINE AND 3-PHOSPHOTYROSINE AND 3-PHOSPHOINOSITIDE lipid binding#GO:0008289;phosphatidylinositol bisphosphate binding#GO:1902936;ion binding#GO:0043167;binding#GO:0005488;phospholipid binding#GO:0005543;anion binding#GO:0043168;small molecule binding#GO:0036094 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HUMAN|HGNC=29465|UniProtKB=Q5T752 Q5T752 LCE1D PTHR48615:SF4 LATE CORNIFIED ENVELOPE PROTEIN 1C LATE CORNIFIED ENVELOPE PROTEIN 1D HUMAN|HGNC=6846|UniProtKB=P52564 P52564 MAP2K6 PTHR48013:SF12 DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;intracellular signaling cassette#GO:0141124;signaling#GO:0023052;biological regulation#GO:0065007;cell communication#GO:0007154;MAPK cascade#GO:0000165;intracellular signal transduction#GO:0035556 non-receptor serine/threonine protein kinase#PC00167 EGF receptor signaling pathway#P00018>MKK3,6#P00540;Ras Pathway#P04393>MKK3/6#P04568;Gonadotropin-releasing hormone receptor pathway#P06664>MKK3/6#P06805;FGF signaling pathway#P00021>MKK3,6#P00625;CCKR signaling map#P06959>MAP2K6#P07233;Oxidative stress response#P00046>MKK3/6#P01121;p38 MAPK pathway#P05918>MKK6#P06032 HUMAN|HGNC=11479|UniProtKB=O43463 O43463 SUV39H1 PTHR46223:SF1 HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H1 catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring one-carbon groups#GO:0016741;protein methyltransferase activity#GO:0008276;lysine N-methyltransferase activity#GO:0016278;histone modifying activity#GO:0140993;histone H3 methyltransferase activity#GO:0140938;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;protein-lysine N-methyltransferase activity#GO:0016279;histone methyltransferase activity#GO:0042054;N-methyltransferase activity#GO:0008170 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 chromatin/chromatin-binding, or -regulatory protein#PC00077;histone modifying enzyme#PC00261 HUMAN|HGNC=1705|UniProtKB=P42081 P42081 CD86 PTHR25466:SF2 T-LYMPHOCYTE ACTIVATION ANTIGEN T-LYMPHOCYTE ACTIVATION ANTIGEN CD86 signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772 response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;plasma membrane#GO:0005886;membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944 immunoglobulin receptor superfamily#PC00124 T cell activation#P00053>B7#P01337 HUMAN|HGNC=34237|UniProtKB=Q05DH4 Q05DH4 FHIP1A PTHR21705:SF6 RAI16 PROTEIN-RELATED FHF COMPLEX SUBUNIT HOOK-INTERACTING PROTEIN 1A HUMAN|HGNC=26800|UniProtKB=Q8TAB5 Q8TAB5 C1orf216 PTHR35673:SF1 UPF0500 PROTEIN C1ORF216 UPF0500 PROTEIN C1ORF216 HUMAN|HGNC=19092|UniProtKB=Q9BQI7 Q9BQI7 PSD2 PTHR10663:SF329 GUANYL-NUCLEOTIDE EXCHANGE FACTOR PH AND SEC7 DOMAIN-CONTAINING PROTEIN 2 ruffle#GO:0001726;cell projection membrane#GO:0031253;ruffle membrane#GO:0032587;leading edge membrane#GO:0031256;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;plasma membrane#GO:0005886;membrane#GO:0016020;cell leading edge#GO:0031252;cell periphery#GO:0071944 guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=30467|UniProtKB=Q6ZT12 Q6ZT12 UBR3 PTHR21497:SF39 UBIQUITIN LIGASE E3 ALPHA-RELATED E3 UBIQUITIN-PROTEIN LIGASE UBR3 ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824 catabolic process#GO:0009056;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;protein modification process#GO:0036211;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein modification by small protein conjugation or removal#GO:0070647;proteasomal protein catabolic process#GO:0010498;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;cellular process#GO:0009987;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152 intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;ubiquitin ligase complex#GO:0000151;transferase complex#GO:1990234;catalytic complex#GO:1902494;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=13141|UniProtKB=Q9NQZ8 Q9NQZ8 ZNF71 PTHR24393:SF186 ZINC FINGER PROTEIN ENDOTHELIAL ZINC FINGER PROTEIN INDUCED BY TUMOR NECROSIS FACTOR ALPHA DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;sequence-specific DNA binding#GO:0043565;DNA-binding transcription activator activity#GO:0001216;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HUMAN|HGNC=25976|UniProtKB=Q0PNE2 Q0PNE2 ELP6 PTHR16184:SF6 ELONGATOR COMPLEX PROTEIN 6 ELONGATOR COMPLEX PROTEIN 6 catalytic complex#GO:1902494;intracellular protein-containing complex#GO:0140535;elongator holoenzyme complex#GO:0033588;protein-containing complex#GO:0032991 HUMAN|HGNC=4397|UniProtKB=Q9BYB4 Q9BYB4 GNB1L PTHR19854:SF1 TRANSDUCIN BETA-LIKE 3 GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-LIKE PROTEIN 1 scaffold/adaptor protein#PC00226 HUMAN|HGNC=11527|UniProtKB=P21452 P21452 TACR2 PTHR46925:SF3 G-PROTEIN COUPLED RECEPTOR TKR-1-RELATED SUBSTANCE-K RECEPTOR neuropeptide receptor activity#GO:0008188;G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 regulation of biological process#GO:0050789;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of cell motility#GO:2000147;regulation of locomotion#GO:0040012;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of microtubule-based movement#GO:0060632;regulation of reproductive process#GO:2000241;regulation of microtubule-based process#GO:0032886;positive regulation of locomotion#GO:0040017;regulation of cell motility#GO:2000145 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;motile cilium#GO:0031514;sperm flagellum#GO:0036126;cellular anatomical structure#GO:0110165;cilium#GO:0005929;9+2 motile cilium#GO:0097729;membrane-bounded organelle#GO:0043227 G-protein coupled receptor#PC00021 HUMAN|HGNC=9621|UniProtKB=Q6IBS0 Q6IBS0 TWF2 PTHR13759:SF9 TWINFILIN TWINFILIN-2 protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;actin monomer binding#GO:0003785;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;actin filament binding#GO:0051015 negative regulation of actin filament depolymerization#GO:0030835;regulation of biological quality#GO:0065008;cellular component disassembly#GO:0022411;regulation of actin filament length#GO:0030832;positive regulation of cellular component organization#GO:0051130;positive regulation of neuron projection development#GO:0010976;regulation of cellular component biogenesis#GO:0044087;negative regulation of actin filament polymerization#GO:0030837;regulation of cellular component organization#GO:0051128;regulation of plasma membrane bounded cell projection assembly#GO:0120032;regulation of organelle organization#GO:0033043;regulation of cellular component size#GO:0032535;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;regulation of protein-containing complex assembly#GO:0043254;negative regulation of biological process#GO:0048519;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;regulation of anatomical structure size#GO:0090066;regulation of actin cytoskeleton organization#GO:0032956;cytoskeleton organization#GO:0007010;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;regulation of neuron projection development#GO:0010975;actin filament depolymerization#GO:0030042;regulation of protein-containing complex disassembly#GO:0043244;organelle organization#GO:0006996;regulation of cell projection assembly#GO:0060491;supramolecular fiber organization#GO:0097435;negative regulation of protein-containing complex assembly#GO:0031333;negative regulation of protein-containing complex disassembly#GO:0043242;negative regulation of cytoskeleton organization#GO:0051494;positive regulation of cell projection organization#GO:0031346;actin filament-based process#GO:0030029;actin filament capping#GO:0051693;negative regulation of protein polymerization#GO:0032272;regulation of actin filament depolymerization#GO:0030834;protein-containing complex disassembly#GO:0032984;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;regulation of protein polymerization#GO:0032271;regulation of cytoskeleton organization#GO:0051493;negative regulation of supramolecular fiber organization#GO:1902904;regulation of supramolecular fiber organization#GO:1902903;negative regulation of organelle organization#GO:0010639;negative regulation of cellular component organization#GO:0051129;regulation of protein depolymerization#GO:1901879;actin filament organization#GO:0007015;regulation of plasma membrane bounded cell projection organization#GO:0120035;negative regulation of cellular process#GO:0048523;regulation of actin filament-based process#GO:0032970;regulation of cell projection organization#GO:0031344;negative regulation of protein depolymerization#GO:1901880;protein depolymerization#GO:0051261;regulation of actin polymerization or depolymerization#GO:0008064;biological regulation#GO:0065007;regulation of actin filament polymerization#GO:0030833;regulation of actin filament organization#GO:0110053;actin polymerization or depolymerization#GO:0008154;positive regulation of cellular process#GO:0048522 contractile muscle fiber#GO:0043292;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;actin filament#GO:0005884;cytoskeleton#GO:0005856;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;actin cytoskeleton#GO:0015629;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;myofibril#GO:0030016 non-motor actin binding protein#PC00165 HUMAN|HGNC=19419|UniProtKB=Q8IZT8 Q8IZT8 HS3ST5 PTHR10605:SF46 HEPARAN SULFATE SULFOTRANSFERASE HEPARAN SULFATE GLUCOSAMINE 3-O-SULFOTRANSFERASE 5 catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring sulphur-containing groups#GO:0016782;sulfotransferase activity#GO:0008146 metabolite interconversion enzyme#PC00262;transferase#PC00220 HUMAN|HGNC=19616|UniProtKB=A6NL26 A6NL26 OR5B21 PTHR48018:SF8 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5B21 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 G protein-coupled receptor signaling pathway#GO:0007186;nervous system process#GO:0050877;sensory perception#GO:0007600;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;sensory perception of smell#GO:0007608;response to stimulus#GO:0050896;signaling#GO:0023052;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;cellular process#GO:0009987;signal transduction#GO:0007165;multicellular organismal process#GO:0032501;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=31849|UniProtKB=P23610 P23610 F8A1 PTHR16797:SF4 FACTOR VIII-ASSOCIATED GENE 1 40-KDA HUNTINGTIN-ASSOCIATED PROTEIN cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;vesicle cytoskeletal trafficking#GO:0099518;organelle localization#GO:0051640;intracellular transport#GO:0046907;transport#GO:0006810;cytoskeleton-dependent intracellular transport#GO:0030705;establishment of organelle localization#GO:0051656;establishment of vesicle localization#GO:0051650;cellular process#GO:0009987;vesicle localization#GO:0051648;establishment of localization in cell#GO:0051649 vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endosome#GO:0005768;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=30750|UniProtKB=Q9BVW5 Q9BVW5 TIPIN PTHR13220:SF12 TIMELESS INTERACTING-RELATED TIMELESS-INTERACTING PROTEIN DNA binding#GO:0003677;nucleic acid binding#GO:0003676;binding#GO:0005488 negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;response to stress#GO:0006950;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of DNA metabolic process#GO:0051053;regulation of nucleobase-containing compound metabolic process#GO:0019219;DNA damage response#GO:0006974;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;negative regulation of DNA-templated DNA replication#GO:2000104;negative regulation of cellular process#GO:0048523;macromolecule metabolic process#GO:0043170;regulation of biological process#GO:0050789;regulation of DNA-templated DNA replication#GO:0090329;cellular response to stimulus#GO:0051716;regulation of DNA metabolic process#GO:0051052;DNA replication#GO:0006260;negative regulation of biological process#GO:0048519;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;negative regulation of metabolic process#GO:0009892;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;cellular response to stress#GO:0033554;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;DNA-templated DNA replication#GO:0006261;regulation of DNA replication#GO:0006275 protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;chromosome#GO:0005694;replication fork#GO:0005657;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;nuclear replication fork#GO:0043596;intracellular organelle#GO:0043229 DNA metabolism protein#PC00009 HUMAN|HGNC=13389|UniProtKB=Q14112 Q14112 NID2 PTHR12352:SF3 SECRETED MODULAR CALCIUM-BINDING PROTEIN NIDOGEN-2 cellular process#GO:0009987;cell adhesion#GO:0007155;cell-matrix adhesion#GO:0007160;cell-substrate adhesion#GO:0031589 external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;basement membrane#GO:0005604;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 calmodulin-related#PC00061 HUMAN|HGNC=4451|UniProtKB=P51654 P51654 GPC3 PTHR10822:SF4 GLYPICAN GLYPICAN-3 cell migration#GO:0016477;positive regulation of Wnt signaling pathway#GO:0030177;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of canonical Wnt signaling pathway#GO:0060828;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;regulation of protein localization to membrane#GO:1905475;positive regulation of biological process#GO:0048518;positive regulation of canonical Wnt signaling pathway#GO:0090263;regulation of localization#GO:0032879;regulation of response to stimulus#GO:0048583;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;cell motility#GO:0048870;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789;positive regulation of signaling#GO:0023056;regulation of protein localization#GO:0032880;regulation of signaling#GO:0023051 membrane#GO:0016020;cell periphery#GO:0071944;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HUMAN|HGNC=6445|UniProtKB=P08729 P08729 KRT7 PTHR45616:SF21 GATA-TYPE DOMAIN-CONTAINING PROTEIN KERATIN, TYPE II CYTOSKELETAL 7 structural molecule activity#GO:0005198 cellular component organization#GO:0016043;intermediate filament cytoskeleton organization#GO:0045104;cell differentiation#GO:0030154;intermediate filament-based process#GO:0045103;animal gross anatomical part developmental process#GO:0160108;keratinocyte differentiation#GO:0030216;intermediate filament organization#GO:0045109;anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;organelle organization#GO:0006996;cellular process#GO:0009987;epithelium development#GO:0060429;tissue development#GO:0009888;multicellular organismal process#GO:0032501;epidermal cell differentiation#GO:0009913;epithelial cell differentiation#GO:0030855;cytoskeleton organization#GO:0007010;skin development#GO:0043588;epidermis development#GO:0008544;developmental process#GO:0032502;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;animal organ development#GO:0048513 organelle#GO:0043226;supramolecular complex#GO:0099080;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;intermediate filament#GO:0005882;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 HUMAN|HGNC=29882|UniProtKB=Q9H1K1 Q9H1K1 ISCU PTHR10093:SF26 IRON-SULFUR CLUSTER ASSEMBLY ENZYME NIFU HOMOLOG IRON-SULFUR CLUSTER ASSEMBLY ENZYME ISCU metal ion binding#GO:0046872;cation binding#GO:0043169;iron-sulfur cluster binding#GO:0051536;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;transition metal ion binding#GO:0046914;iron ion binding#GO:0005506;ferrous iron binding#GO:0008198 chemical homeostasis#GO:0048878;intracellular monoatomic cation homeostasis#GO:0030003;inorganic ion homeostasis#GO:0098771;monoatomic cation homeostasis#GO:0055080;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion homeostasis#GO:0050801;homeostatic process#GO:0042592;intracellular iron ion homeostasis#GO:0006879 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229 chaperone#PC00072 HUMAN|HGNC=25518|UniProtKB=Q9BW85 Q9BW85 YJU2 PTHR12111:SF1 SPLICING FACTOR YJU2 SPLICING FACTOR YJU2 spliceosomal complex#GO:0005681;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;U2-type spliceosomal complex#GO:0005684;intracellular membrane-bounded organelle#GO:0043231;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148 HUMAN|HGNC=34522|UniProtKB=Q6UXS0 Q6UXS0 CLEC19A PTHR22803:SF171 MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED C-TYPE LECTIN DOMAIN FAMILY 19 MEMBER A membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=29159|UniProtKB=Q5SYB0 Q5SYB0 FRMPD1 PTHR46221:SF2 FERM AND PDZ DOMAIN-CONTAINING PROTEIN FAMILY MEMBER FERM AND PDZ DOMAIN-CONTAINING PROTEIN 1 cell cortex#GO:0005938;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=17147|UniProtKB=Q9H3Q1 Q9H3Q1 CDC42EP4 PTHR15344:SF14 CDC42 EFFECTOR PROTEIN BORG CDC42 EFFECTOR PROTEIN 4 small GTPase binding#GO:0031267;protein binding#GO:0005515;enzyme binding#GO:0019899;binding#GO:0005488 regulation of anatomical structure size#GO:0090066;regulation of anatomical structure morphogenesis#GO:0022603;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of cellular component biogenesis#GO:0044089;regulation of actin cytoskeleton organization#GO:0032956;intracellular signaling cassette#GO:0141124;regulation of actin filament length#GO:0030832;positive regulation of cellular component organization#GO:0051130;positive regulation of organelle organization#GO:0010638;Rho protein signal transduction#GO:0007266;regulation of biological quality#GO:0065008;regulation of protein-containing complex assembly#GO:0043254;cellular component organization#GO:0016043;regulation of cell shape#GO:0008360;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of cellular component size#GO:0032535;response to stimulus#GO:0050896;regulation of cellular component organization#GO:0051128;regulation of plasma membrane bounded cell projection assembly#GO:0120032;regulation of cellular component biogenesis#GO:0044087;signaling#GO:0023052;regulation of actin filament-based process#GO:0032970;regulation of cell projection organization#GO:0031344;regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of actin filament organization#GO:0110053;positive regulation of cellular process#GO:0048522;positive regulation of protein polymerization#GO:0032273;regulation of actin filament polymerization#GO:0030833;regulation of actin polymerization or depolymerization#GO:0008064;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;positive regulation of cell projection organization#GO:0031346;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of cell projection assembly#GO:0060491;cellular response to stimulus#GO:0051716;regulation of supramolecular fiber organization#GO:1902903;regulation of cellular process#GO:0050794;regulation of cytoskeleton organization#GO:0051493;regulation of protein polymerization#GO:0032271;regulation of developmental process#GO:0050793 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=5289|UniProtKB=P28221 P28221 HTR1D PTHR24247:SF17 5-HYDROXYTRYPTAMINE RECEPTOR 5-HYDROXYTRYPTAMINE RECEPTOR 1D transmembrane signaling receptor activity#GO:0004888;G protein-coupled amine receptor activity#GO:0008227;neurotransmitter receptor activity#GO:0030594;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930 chemical synaptic transmission#GO:0007268;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;anterograde trans-synaptic signaling#GO:0098916;signaling#GO:0023052;trans-synaptic signaling#GO:0099537;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;synaptic signaling#GO:0099536;cellular process#GO:0009987;signal transduction#GO:0007165;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway#GO:0007193;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188 dendritic tree#GO:0097447;dendrite#GO:0030425;cell periphery#GO:0071944;neuron projection#GO:0043005;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;somatodendritic compartment#GO:0036477;cell projection#GO:0042995;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;5HT1 type receptor mediated signaling pathway#P04373>5HT1 Receptor#P04404;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GsPCR#P00720 HUMAN|HGNC=11353|UniProtKB=Q99469 Q99469 STAC PTHR15135:SF3 STAC SH3 AND CYSTEINE-RICH DOMAIN-CONTAINING PROTEIN molecular function regulator activity#GO:0098772;channel regulator activity#GO:0016247;transporter regulator activity#GO:0141108;ion channel regulator activity#GO:0099106;calcium channel regulator activity#GO:0005246 positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of protein localization to membrane#GO:1905475;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;muscle contraction#GO:0006936;regulation of localization#GO:0032879;system process#GO:0003008;regulation of biological process#GO:0050789;muscle system process#GO:0003012;regulation of cellular process#GO:0050794;striated muscle contraction#GO:0006941;skeletal muscle contraction#GO:0003009;nervous system process#GO:0050877;neuromuscular process#GO:0050905;regulation of protein localization#GO:0032880 cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;plasma membrane#GO:0005886;cytoplasmic side of plasma membrane#GO:0009898;membrane#GO:0016020;cytoplasmic side of membrane#GO:0098562;cell periphery#GO:0071944 HUMAN|HGNC=11769|UniProtKB=P10600 P10600 TGFB3 PTHR11848:SF34 TGF-BETA FAMILY TRANSFORMING GROWTH FACTOR BETA-3 PROPROTEIN cytokine activity#GO:0005125;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772 cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;cell surface receptor signaling pathway#GO:0007166;developmental process#GO:0032502;animal organ development#GO:0048513;multicellular organism development#GO:0007275;transforming growth factor beta receptor signaling pathway#GO:0007179;cellular process#GO:0009987;signal transduction#GO:0007165;multicellular organismal process#GO:0032501;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;heart development#GO:0007507;biological regulation#GO:0065007;animal gross anatomical part developmental process#GO:0160108;response to transforming growth factor beta#GO:0071559;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;system development#GO:0048731;cellular response to growth factor stimulus#GO:0071363;response to endogenous stimulus#GO:0009719;cellular response to transforming growth factor beta stimulus#GO:0071560;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;cellular response to endogenous stimulus#GO:0071495;response to growth factor#GO:0070848;circulatory system development#GO:0072359;response to stimulus#GO:0050896;signaling#GO:0023052 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 growth factor#PC00112 TGF-beta signaling pathway#P00052>TGFbeta#P01286 HUMAN|HGNC=29995|UniProtKB=P08218 P08218 CELA2B PTHR24257:SF19 CHYMOTRYPSIN-LIKE ELASTASE FAMILY MEMBER CHYMOTRYPSIN-LIKE ELASTASE FAMILY MEMBER 2B serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175 protein metabolic process#GO:0019538;regulation of platelet aggregation#GO:0090330;regulation of platelet activation#GO:0010543;proteolysis#GO:0006508;protein catabolic process#GO:0030163;regulation of cell-cell adhesion#GO:0022407;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;primary metabolic process#GO:0044238;regulation of cell activation#GO:0050865;regulation of biological process#GO:0050789;macromolecule metabolic process#GO:0043170;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;regulation of cell adhesion#GO:0030155;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 serine protease#PC00203;protease#PC00190;protein modifying enzyme#PC00260 HUMAN|HGNC=1378|UniProtKB=Q9Y2D0 Q9Y2D0 CA5B PTHR18952:SF25 CARBONIC ANHYDRASE CARBONIC ANHYDRASE 5B, MITOCHONDRIAL catalytic activity#GO:0003824;carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;hydro-lyase activity#GO:0016836 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 dehydratase#PC00091;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=13352|UniProtKB=Q9GZQ8 Q9GZQ8 MAP1LC3B PTHR10969:SF15 MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED MICROTUBULE-ASSOCIATED PROTEIN 1 LIGHT CHAIN 3 BETA-RELATED cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;phospholipid binding#GO:0005543;ubiquitin-like protein ligase binding#GO:0044389;ubiquitin protein ligase binding#GO:0031625;enzyme binding#GO:0019899;microtubule binding#GO:0008017;binding#GO:0005488;lipid binding#GO:0008289;protein binding#GO:0005515 vacuole organization#GO:0007033;process utilizing autophagic mechanism#GO:0061919;cellular component disassembly#GO:0022411;cellular response to stress#GO:0033554;organelle assembly#GO:0070925;protein-containing complex disassembly#GO:0032984;catabolic process#GO:0009056;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;response to starvation#GO:0042594;cellular component organization#GO:0016043;autophagosome assembly#GO:0000045;protein-containing complex organization#GO:0043933;mitophagy#GO:0000423;cellular component organization or biogenesis#GO:0071840;cellular response to nutrient levels#GO:0031669;metabolic process#GO:0008152;cellular response to starvation#GO:0009267;autophagy of mitochondrion#GO:0000422;autophagosome maturation#GO:0097352;macroautophagy#GO:0016236;cellular component assembly#GO:0022607;autophagy#GO:0006914;cellular process#GO:0009987;autophagosome organization#GO:1905037;response to nutrient levels#GO:0031667;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;response to stress#GO:0006950 intracellular organelle#GO:0043229;autophagosome#GO:0005776;membrane-bounded organelle#GO:0043227;autophagosome membrane#GO:0000421;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;vacuolar membrane#GO:0005774;membrane#GO:0016020;vacuole#GO:0005773;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 microtubule or microtubule-binding cytoskeletal protein#PC00157;cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HUMAN|HGNC=7665|UniProtKB=O43639 O43639 NCK2 PTHR19969:SF12 SH2-SH3 ADAPTOR PROTEIN-RELATED CYTOPLASMIC PROTEIN NCK2 molecular adaptor activity#GO:0060090;receptor tyrosine kinase binding#GO:0030971;binding#GO:0005488;kinase binding#GO:0019900;protein tyrosine kinase binding#GO:1990782;signaling receptor binding#GO:0005102;protein-macromolecule adaptor activity#GO:0030674;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;signaling adaptor activity#GO:0035591;protein binding#GO:0005515 cellular response to stress#GO:0033554;regulation of signaling#GO:0023051;positive regulation of protein metabolic process#GO:0051247;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;regulation of cellular response to stress#GO:0080135;negative regulation of cell communication#GO:0010648;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of signaling#GO:0023056;negative regulation of intracellular signal transduction#GO:1902532;regulation of biological process#GO:0050789;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;signaling#GO:0023052;response to stimulus#GO:0050896;positive regulation of programmed cell death#GO:0043068;cell surface receptor signaling pathway#GO:0007166;regulation of apoptotic process#GO:0042981;positive regulation of apoptotic process#GO:0043065;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of protein metabolic process#GO:0051246;response to stress#GO:0006950;negative regulation of signal transduction#GO:0009968;positive regulation of macromolecule metabolic process#GO:0010604;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of apoptotic signaling pathway#GO:2001233;response to endoplasmic reticulum stress#GO:0034976;positive regulation of translation#GO:0045727;positive regulation of biosynthetic process#GO:0009891;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of response to endoplasmic reticulum stress#GO:1905897;regulation of intrinsic apoptotic signaling pathway#GO:2001242;ephrin receptor signaling pathway#GO:0048013;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;positive regulation of apoptotic signaling pathway#GO:2001235;regulation of cell communication#GO:0010646;regulation of macromolecule metabolic process#GO:0060255;positive regulation of cell communication#GO:0010647;cell motility#GO:0048870;regulation of cellular process#GO:0050794;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;regulation of response to stress#GO:0080134;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;cell migration#GO:0016477;negative regulation of response to stimulus#GO:0048585 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 PDGF signaling pathway#P00047>Nck#P01147;Angiogenesis#P00005>Nck#P00215;T cell activation#P00053>nck#P01314 HUMAN|HGNC=34353|UniProtKB=Q2NKX9 Q2NKX9 C2orf68 PTHR34256:SF1 UPF0561 PROTEIN C2ORF68 UPF0561 PROTEIN C2ORF68 HUMAN|HGNC=33626|UniProtKB=A6NGY1 A6NGY1 FRG2C PTHR31883:SF1 PROTEIN FRG2-RELATED PROTEIN FRG2-LIKE-2 HUMAN|HGNC=32260|UniProtKB=A8MX19 A8MX19 FAM90A12 PTHR16035:SF14 PROTEIN FAM90A1 PROTEIN FAM90A10-RELATED HUMAN|HGNC=10330|UniProtKB=P46779 P46779 RPL28 PTHR10544:SF12 60S RIBOSOMAL PROTEIN L28 LARGE RIBOSOMAL SUBUNIT PROTEIN EL28 cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;cytosolic large ribosomal subunit#GO:0022625;cytosolic ribosome#GO:0022626;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904 translational protein#PC00263;ribosomal protein#PC00202 HUMAN|HGNC=29058|UniProtKB=O60268 O60268 KIAA0513 PTHR13663:SF2 SIMILAR TO RIKEN CDNA 6430548M08 RIKEN CDNA 6430548M08 GENE LIKE HUMAN|HGNC=30552|UniProtKB=Q6ZMN7 Q6ZMN7 PDZRN4 PTHR15545:SF6 PDZ DOMAIN CONTAINING RING FINGER PROTEIN 3, 4 PDZ DOMAIN-CONTAINING RING FINGER PROTEIN 4 HUMAN|HGNC=3431|UniProtKB=P21860 P21860 ERBB3 PTHR24416:SF88 TYROSINE-PROTEIN KINASE RECEPTOR RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3 transmembrane receptor protein tyrosine kinase activity#GO:0004714;molecular transducer activity#GO:0060089;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity, acting on a protein#GO:0140096;transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488;protein kinase activity#GO:0004672;growth factor binding#GO:0019838;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein binding#GO:0005515;kinase activity#GO:0016301;transferase activity#GO:0016740;signaling receptor activity#GO:0038023 positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;positive regulation of epithelial cell proliferation#GO:0050679;regulation of cell communication#GO:0010646;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of cell population proliferation#GO:0042127;cell communication#GO:0007154;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;system development#GO:0048731;positive regulation of cellular process#GO:0048522;ERBB signaling pathway#GO:0038127;positive regulation of response to stimulus#GO:0048584;negative regulation of apoptotic process#GO:0043066;epidermal growth factor receptor signaling pathway#GO:0007173;multicellular organismal process#GO:0032501;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;positive regulation of intracellular signal transduction#GO:1902533;developmental process#GO:0032502;regulation of response to stimulus#GO:0048583;positive regulation of MAPK cascade#GO:0043410;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;positive regulation of cell population proliferation#GO:0008284;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;cell differentiation#GO:0030154;response to stimulus#GO:0050896;signaling#GO:0023052;animal gross anatomical part developmental process#GO:0160108;regulation of intracellular signal transduction#GO:1902531;generation of neurons#GO:0048699;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;positive regulation of biological process#GO:0048518;negative regulation of programmed cell death#GO:0043069;signal transduction#GO:0007165;cellular process#GO:0009987;nervous system development#GO:0007399;regulation of MAPK cascade#GO:0043408;neuron differentiation#GO:0030182;regulation of apoptotic process#GO:0042981;cell surface receptor signaling pathway#GO:0007166;multicellular organism development#GO:0007275 basal part of cell#GO:0045178;membrane#GO:0016020;basal plasma membrane#GO:0009925;cell periphery#GO:0071944;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;signaling receptor complex#GO:0043235 transmembrane signal receptor#PC00197 EGF receptor signaling pathway#P00018>EGFR#P00542;Cadherin signaling pathway#P00012>EGFR#P00466 HUMAN|HGNC=3969|UniProtKB=P23945 P23945 FSHR PTHR24372:SF5 GLYCOPROTEIN HORMONE RECEPTOR FOLLICLE-STIMULATING HORMONE RECEPTOR G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930 gonad development#GO:0008406;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;male sex differentiation#GO:0046661;developmental process#GO:0032502;development of primary male sexual characteristics#GO:0046546;reproductive process#GO:0022414;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;developmental process involved in reproduction#GO:0003006;reproductive system development#GO:0061458;multicellular organismal reproductive process#GO:0048609;female gonad development#GO:0008585;system development#GO:0048731;anatomical structure development#GO:0048856;cell communication#GO:0007154;response to chemical#GO:0042221;sex differentiation#GO:0007548;cellular process#GO:0009987;male gonad development#GO:0008584;signal transduction#GO:0007165;response to hormone#GO:0009725;animal organ development#GO:0048513;multicellular organism development#GO:0007275;development of primary sexual characteristics#GO:0045137;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;reproductive structure development#GO:0048608;signaling#GO:0023052;cellular response to hormone stimulus#GO:0032870;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;hormone-mediated signaling pathway#GO:0009755;rhythmic process#GO:0048511;animal gross anatomical part developmental process#GO:0160108;G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HUMAN|HGNC=6797|UniProtKB=P43363 P43363 MAGEA10 PTHR11736:SF153 MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN MELANOMA-ASSOCIATED ANTIGEN 10 negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 scaffold/adaptor protein#PC00226 HUMAN|HGNC=19876|UniProtKB=Q9H2F5 Q9H2F5 EPC1 PTHR14898:SF6 ENHANCER OF POLYCOMB ENHANCER OF POLYCOMB HOMOLOG 1 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;chromatin organization#GO:0006325;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219 chromatin#GO:0000785;NuA4 histone acetyltransferase complex#GO:0035267;H4 histone acetyltransferase complex#GO:1902562;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;transferase complex#GO:1990234;membraneless organelle#GO:0043228;histone acetyltransferase complex#GO:0000123;intracellular protein-containing complex#GO:0140535;chromosome#GO:0005694;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;protein acetyltransferase complex#GO:0031248;acetyltransferase complex#GO:1902493;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=25594|UniProtKB=Q9P2K3 Q9P2K3 RCOR3 PTHR16089:SF13 REST COREPRESSOR COREST PROTEIN-RELATED REST COREPRESSOR 3 transcription regulator activity#GO:0140110;transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712 regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934 nuclear protein-containing complex#GO:0140513;transcription regulator complex#GO:0005667;membrane-enclosed lumen#GO:0031974;histone deacetylase complex#GO:0000118;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=2755|UniProtKB=O75618 O75618 DEDD PTHR15205:SF2 DEATH EFFECTOR DOMAIN-CONTAINING PROTEIN DEATH EFFECTOR DOMAIN-CONTAINING PROTEIN regulation of cellular process#GO:0050794;extrinsic apoptotic signaling pathway#GO:0097191;response to stimulus#GO:0050896;signaling#GO:0023052;programmed cell death#GO:0012501;cell death#GO:0008219;cellular response to stimulus#GO:0051716;apoptotic process#GO:0006915;regulation of biological process#GO:0050789;cell communication#GO:0007154;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;extrinsic apoptotic signaling pathway via death domain receptors#GO:0008625;apoptotic signaling pathway#GO:0097190;cell surface receptor signaling pathway#GO:0007166 organelle lumen#GO:0043233;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;membraneless organelle#GO:0043228 HUMAN|HGNC=29329|UniProtKB=Q9HCE9 Q9HCE9 ANO8 PTHR12308:SF51 ANOCTAMIN ANOCTAMIN-8 intramembrane lipid carrier activity#GO:0140303;lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104;phospholipid scramblase activity#GO:0017128;transporter activity#GO:0005215 transport#GO:0006810;regulation of membrane lipid distribution#GO:0097035;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;macromolecule localization#GO:0033036;phospholipid translocation#GO:0045332;phospholipid transport#GO:0015914;membrane organization#GO:0061024;biological regulation#GO:0065007;lipid transport#GO:0006869;lipid localization#GO:0010876;regulation of biological quality#GO:0065008;localization#GO:0051179;cellular component organization#GO:0016043;lipid translocation#GO:0034204;organophosphate ester transport#GO:0015748 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=16664|UniProtKB=A8MX76 A8MX76 CAPN14 PTHR10183:SF302 CALPAIN CALPAIN-14 catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;cysteine-type endopeptidase activity#GO:0004197;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 cellular process#GO:0009987;primary metabolic process#GO:0044238;proteolysis#GO:0006508;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 cysteine protease#PC00081;protease#PC00190 HUMAN|HGNC=25951|UniProtKB=Q6ULP2 Q6ULP2 AFTPH PTHR16156:SF9 AFTIPHILIN A-RELATED AFTIPHILIN clathrin binding#GO:0030276;binding#GO:0005488;protein binding#GO:0005515 organelle#GO:0043226;clathrin coat#GO:0030118;cellular anatomical structure#GO:0110165;Golgi-associated vesicle membrane#GO:0030660;coated vesicle membrane#GO:0030662;intracellular vesicle#GO:0097708;coated membrane#GO:0048475;organelle subcompartment#GO:0031984;coated vesicle#GO:0030135;intracellular organelle#GO:0043229;trans-Golgi network membrane#GO:0032588;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;vesicle coat#GO:0030120;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;clathrin-coated vesicle membrane#GO:0030665;AP-type membrane coat adaptor complex#GO:0030119;bounding membrane of organelle#GO:0098588;clathrin vesicle coat#GO:0030125;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;vesicle#GO:0031982;membrane coat#GO:0030117;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;trans-Golgi network transport vesicle#GO:0030140;AP-1 adaptor complex#GO:0030121;transport vesicle#GO:0030133;transport vesicle membrane#GO:0030658;endomembrane system#GO:0012505;vesicle membrane#GO:0012506;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;organelle membrane#GO:0031090;Golgi-associated vesicle#GO:0005798;Golgi apparatus#GO:0005794;trans-Golgi network transport vesicle membrane#GO:0012510;clathrin-coated vesicle#GO:0030136 HUMAN|HGNC=24997|UniProtKB=A4D1P6 A4D1P6 WDR91 PTHR13083:SF3 WD REPEAT-CONTAINING PROTEIN 91 WD REPEAT-CONTAINING PROTEIN 91 molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;enzyme regulator activity#GO:0030234 establishment of localization in cell#GO:0051649;early endosome to late endosome transport#GO:0045022;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;transport#GO:0006810;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;endosomal transport#GO:0016197 intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;endosome#GO:0005768;endosome membrane#GO:0010008;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;vesicle membrane#GO:0012506;membrane#GO:0016020;late endosome#GO:0005770;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;late endosome membrane#GO:0031902;early endosome membrane#GO:0031901;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588 HUMAN|HGNC=13237|UniProtKB=Q9UK28 Q9UK28 TMEM59L PTHR28652:SF1 TRANSMEMBRANE PROTEIN 59-LIKE PROTEIN TRANSMEMBRANE PROTEIN 59-LIKE HUMAN|HGNC=28458|UniProtKB=Q9BWN1 Q9BWN1 PRR14 PTHR14522:SF2 EMO2-RELATED PROLINE-RICH PROTEIN 14 intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 HUMAN|HGNC=4005|UniProtKB=Q96I24 Q96I24 FUBP3 PTHR10288:SF234 KH DOMAIN CONTAINING RNA BINDING PROTEIN FAR UPSTREAM ELEMENT-BINDING PROTEIN 3 binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;mRNA 3'-UTR binding#GO:0003730;RNA binding#GO:0003723 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 RNA metabolism protein#PC00031 HUMAN|HGNC=19048|UniProtKB=Q8IZT6 Q8IZT6 ASPM PTHR22590:SF4 MYOSIN MOTOR DOMAIN-CONTAINING PROTEIN ABNORMAL SPINDLE-LIKE MICROCEPHALY-ASSOCIATED PROTEIN HUMAN|HGNC=33874|UniProtKB=Q6DKI2 Q6DKI2 LGALS9C PTHR11346:SF194 GALECTIN GALECTIN-9C carbohydrate derivative binding#GO:0097367;binding#GO:0005488;carbohydrate binding#GO:0030246 negative regulation of multicellular organismal process#GO:0051241;negative regulation of leukocyte cell-cell adhesion#GO:1903038;regulation of cell-cell adhesion#GO:0022407;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of T cell proliferation#GO:0042129;regulation of macromolecule metabolic process#GO:0060255;negative regulation of T cell activation#GO:0050868;regulation of cell population proliferation#GO:0042127;positive regulation of biosynthetic process#GO:0009891;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;negative regulation of cell population proliferation#GO:0008285;regulation of macromolecule biosynthetic process#GO:0010556;regulation of cytokine production#GO:0001817;negative regulation of biosynthetic process#GO:0009890;negative regulation of immune system process#GO:0002683;biological regulation#GO:0065007;regulation of lymphocyte proliferation#GO:0050670;regulation of cell adhesion#GO:0030155;negative regulation of cell adhesion#GO:0007162;negative regulation of cellular process#GO:0048523;regulation of leukocyte cell-cell adhesion#GO:1903037;regulation of gene expression#GO:0010468;positive regulation of gene expression#GO:0010628;regulation of biosynthetic process#GO:0009889;negative regulation of cell activation#GO:0050866;regulation of cell activation#GO:0050865;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of leukocyte activation#GO:0002694;regulation of lymphocyte activation#GO:0051249;negative regulation of metabolic process#GO:0009892;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biological process#GO:0048518;regulation of mononuclear cell proliferation#GO:0032944;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of multicellular organismal process#GO:0051239;negative regulation of lymphocyte activation#GO:0051250;negative regulation of leukocyte activation#GO:0002695;regulation of T cell activation#GO:0050863;positive regulation of macromolecule metabolic process#GO:0010604;negative regulation of cell-cell adhesion#GO:0022408;negative regulation of T cell proliferation#GO:0042130;regulation of leukocyte proliferation#GO:0070663 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 extracellular matrix protein#PC00102 HUMAN|HGNC=1539|UniProtKB=Q13951 Q13951 CBFB PTHR10276:SF3 CORE-BINDING FACTOR, BETA SUBUNIT CORE-BINDING FACTOR SUBUNIT BETA transcription coregulator activity#GO:0003712;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;transcription coactivator activity#GO:0003713;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 HUMAN|HGNC=3277|UniProtKB=P60228 P60228 EIF3E PTHR10317:SF3 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT E EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT E translation factor activity#GO:0180051;translation initiation factor activity#GO:0003743 translational initiation#GO:0006413;translation#GO:0006412;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;protein biosynthetic process#GO:0160307;gene expression#GO:0010467 eukaryotic translation initiation factor 3 complex#GO:0005852;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 translation initiation factor#PC00224;translation factor#PC00223 HUMAN|HGNC=14305|UniProtKB=Q8N3K9 Q8N3K9 CMYA5 PTHR24099:SF7 E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED CARDIOMYOPATHY-ASSOCIATED PROTEIN 5 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=13671|UniProtKB=Q96KK5 Q96KK5 H2AC12 PTHR23430:SF29 HISTONE H2A HISTONE H2A TYPE 1-H structural molecule activity#GO:0005198 chromatin organization#GO:0006325;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;heterochromatin organization#GO:0070828;cellular component assembly#GO:0022607;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of metabolic process#GO:0019222;epigenetic regulation of gene expression#GO:0040029;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;cellular component organization or biogenesis#GO:0071840;negative regulation of gene expression, epigenetic#GO:0045814;regulation of biosynthetic process#GO:0009889;negative regulation of cellular process#GO:0048523;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;heterochromatin formation#GO:0031507;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043 intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;chromosome#GO:0005694;chromatin#GO:0000785;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;protein-DNA complex#GO:0032993;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;nucleosome#GO:0000786 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=28772|UniProtKB=Q9BVC5 Q9BVC5 C2orf49 PTHR28359:SF1 ASHWIN TRNA-SPLICING LIGASE COMPLEX SUBUNIT ASW nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;tRNA splicing, via endonucleolytic cleavage and ligation#GO:0006388;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033 protein-containing complex#GO:0032991;intracellular protein-containing complex#GO:0140535;catalytic complex#GO:1902494 HUMAN|HGNC=7125|UniProtKB=P58340 P58340 MLF1 PTHR13105:SF22 MYELOID LEUKEMIA FACTOR MYELOID LEUKEMIA FACTOR 1 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634 intercellular signal molecule#PC00207 HUMAN|HGNC=33893|UniProtKB=Q6S8J7 Q6S8J7 POTEA PTHR24147:SF68 ANKYRIN REPEAT DOMAIN 36-RELATED POTE ANKYRIN DOMAIN FAMILY MEMBER A HUMAN|HGNC=29420|UniProtKB=Q96DX4 Q96DX4 RSPRY1 PTHR13363:SF6 RING FINGER AND SRY DOMAIN-CONTAINING RING FINGER AND SPRY DOMAIN-CONTAINING PROTEIN 1 ubiquitin-protein transferase activity#GO:0004842;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746 macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;cellular process#GO:0009987;catabolic process#GO:0009056 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=34073|UniProtKB=A8MVS5 A8MVS5 HIDE1 PTHR36859:SF1 PROTEIN HIDE1 PROTEIN HIDE1 HUMAN|HGNC=22411|UniProtKB=Q8N7C7 Q8N7C7 RNF148 PTHR22765:SF53 RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING RING FINGER PROTEIN 148 catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842 endosome#GO:0005768;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;late endosome#GO:0005770;organelle#GO:0043226 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=25577|UniProtKB=Q9HCJ3 Q9HCJ3 RAVER2 PTHR23189:SF6 RNA RECOGNITION MOTIF-CONTAINING RIBONUCLEOPROTEIN PTB-BINDING 2 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 RNA metabolism protein#PC00031 HUMAN|HGNC=11004|UniProtKB=Q14542 Q14542 SLC29A2 PTHR10332:SF8 EQUILIBRATIVE NUCLEOSIDE TRANSPORTER EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 2 carbohydrate derivative transmembrane transporter activity#GO:1901505;nucleoside transmembrane transporter activity#GO:0005337;nucleobase-containing compound transmembrane transporter activity#GO:0015932;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 pyrimidine nucleobase transport#GO:0015855;transport#GO:0006810;nucleobase transport#GO:0015851;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;carbohydrate derivative transport#GO:1901264;cellular process#GO:0009987;nitrogen compound transport#GO:0071705;nucleobase-containing compound transport#GO:0015931 basal plasma membrane#GO:0009925;cell periphery#GO:0071944;basal part of cell#GO:0045178;basolateral plasma membrane#GO:0016323;membrane#GO:0016020;plasma membrane#GO:0005886;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165 transporter#PC00227 HUMAN|HGNC=26635|UniProtKB=Q8IWF6 Q8IWF6 DENND6A PTHR13677:SF1 LD41638P PROTEIN DENND6A enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 positive regulation of cell-cell adhesion#GO:0022409;regulation of biological process#GO:0050789;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of cell adhesion#GO:0045785;regulation of cell adhesion#GO:0030155;regulation of cellular process#GO:0050794;regulation of cell-cell adhesion#GO:0022407;biological regulation#GO:0065007 intracellular organelle#GO:0043229;endosome#GO:0005768;recycling endosome#GO:0055037;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;vesicle#GO:0031982;intracellular vesicle#GO:0097708;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 HUMAN|HGNC=8772|UniProtKB=Q9Y233 Q9Y233 PDE10A PTHR11347:SF111 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE CAMP AND CAMP-INHIBITED CGMP 3',5'-CYCLIC PHOSPHODIESTERASE 10A catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;phosphoric diester hydrolase activity#GO:0008081;cyclic-nucleotide phosphodiesterase activity#GO:0004112 negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of response to stimulus#GO:0048585;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648 phosphodiesterase#PC00185;hydrolase#PC00121 HUMAN|HGNC=9706|UniProtKB=Q15223 Q15223 NECTIN1 PTHR23277:SF69 NECTIN-RELATED NECTIN-1 binding#GO:0005488;cell adhesion mediator activity#GO:0098631;cell adhesion molecule binding#GO:0050839;virus receptor activity#GO:0001618;protein binding#GO:0005515 macromolecule localization#GO:0033036;homophilic cell-cell adhesion#GO:0007156;cell-cell adhesion#GO:0098609;heterophilic cell-cell adhesion#GO:0007157;cellular process#GO:0009987;protein localization to cell junction#GO:1902414;cell adhesion#GO:0007155;localization#GO:0051179;intracellular protein localization#GO:0008104 cell junction#GO:0030054;adherens junction#GO:0005912;anchoring junction#GO:0070161;apical junction complex#GO:0043296;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell-cell junction#GO:0005911;cell periphery#GO:0071944 cell adhesion molecule#PC00069 Alzheimer disease-presenilin pathway#P00004>Nectin 1alpha#P00160;Alzheimer disease-presenilin pathway#P00004>Nectin 1alpha N-terminal fragment#P00164;Alzheimer disease-presenilin pathway#P00004>Nectin 1alpha C-terminal fragment#P00177;Alzheimer disease-presenilin pathway#P00004>Nectin 1alpha transmembrane fragment#P00134;Alzheimer disease-presenilin pathway#P00004>Nectin 1alpha intracellular fragment#P00159 HUMAN|HGNC=15193|UniProtKB=Q8NGF3 Q8NGF3 OR51D1 PTHR26450:SF166 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 51D1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=7745|UniProtKB=P51955 P51955 NEK2 PTHR43671:SF115 SERINE/THREONINE-PROTEIN KINASE NEK SERINE_THREONINE-PROTEIN KINASE NEK2 protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096 cytoskeleton organization#GO:0007010;cellular process#GO:0009987;cell cycle G2/M phase transition#GO:0044839;organelle organization#GO:0006996;microtubule-based process#GO:0007017;microtubule organizing center organization#GO:0031023;mitotic cell cycle process#GO:1903047;cellular component organization or biogenesis#GO:0071840;chromosome segregation#GO:0007059;G2/M transition of mitotic cell cycle#GO:0000086;cell cycle phase transition#GO:0044770;mitotic cell cycle#GO:0000278;cell cycle process#GO:0022402;centrosome cycle#GO:0007098;cellular component organization#GO:0016043;cell cycle#GO:0007049;microtubule cytoskeleton organization#GO:0000226;mitotic cell cycle phase transition#GO:0044772 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytoskeleton#GO:0005856;centrosome#GO:0005813;microtubule organizing center#GO:0005815;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;nucleus#GO:0005634 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=20482|UniProtKB=Q96P53 Q96P53 WDFY2 PTHR46189:SF3 LD41958P WD REPEAT AND FYVE DOMAIN-CONTAINING PROTEIN 2 regulation of developmental process#GO:0050793;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;positive regulation of biological process#GO:0048518;regulation of cell differentiation#GO:0045595;positive regulation of cell differentiation#GO:0045597;positive regulation of developmental process#GO:0051094;positive regulation of fat cell differentiation#GO:0045600 intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;endosome#GO:0005768;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410 HUMAN|HGNC=18453|UniProtKB=Q8NCW5 Q8NCW5 NAXE PTHR13232:SF11 NAD(P)H-HYDRATE EPIMERASE NAD(P)H-HYDRATE EPIMERASE isomerase activity#GO:0016853;catalytic activity#GO:0003824;racemase and epimerase activity#GO:0016854 mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;epimerase/racemase#PC00096 HUMAN|HGNC=7020|UniProtKB=Q16820 Q16820 MEP1B PTHR10127:SF814 DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING MEPRIN A SUBUNIT BETA metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease#PC00190;metalloprotease#PC00153 HUMAN|HGNC=9355|UniProtKB=P30044 P30044 PRDX5 PTHR10430:SF41 PEROXIREDOXIN PEROXIREDOXIN-5, MITOCHONDRIAL oxidoreductase activity, acting on peroxide as acceptor#GO:0016684;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;antioxidant activity#GO:0016209;peroxidase activity#GO:0004601 response to oxidative stress#GO:0006979;cellular response to chemical stress#GO:0062197;cell redox homeostasis#GO:0045454;cellular homeostasis#GO:0019725;metabolic process#GO:0008152;reactive oxygen species metabolic process#GO:0072593;response to chemical#GO:0042221;cellular response to oxidative stress#GO:0034599;response to stress#GO:0006950;cellular process#GO:0009987;cellular response to chemical stimulus#GO:0070887;cellular response to stress#GO:0033554;catabolic process#GO:0009056;response to stimulus#GO:0050896;homeostatic process#GO:0042592;hydrogen peroxide metabolic process#GO:0042743;cellular response to stimulus#GO:0051716 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;microbody#GO:0042579;peroxisome#GO:0005777;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 oxidoreductase#PC00176 HUMAN|HGNC=8396|UniProtKB=Q6IFN5 Q6IFN5 OR7E24 PTHR48001:SF47 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 7E24 transmembrane signal receptor#PC00197 HUMAN|HGNC=26709|UniProtKB=Q8N9R8 Q8N9R8 SCAI PTHR21243:SF21 PROTEIN SCAI PROTEIN SCAI transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714 biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of signal transduction#GO:0009968;negative regulation of response to stimulus#GO:0048585;regulation of small GTPase mediated signal transduction#GO:0051056;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of Rho protein signal transduction#GO:0035023;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=5644|UniProtKB=A0A0B4J2B5 A0A0B4J2B5 IGHV3OR16-9 PTHR23266:SF298 IMMUNOGLOBULIN HEAVY CHAIN IG-LIKE DOMAIN-CONTAINING PROTEIN binding#GO:0005488;antigen binding#GO:0003823 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;immune effector process#GO:0002252;immune system process#GO:0002376;adaptive immune response#GO:0002250;response to stimulus#GO:0050896;immune response#GO:0006955 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=30563|UniProtKB=Q7L3T8 Q7L3T8 PARS2 PTHR42753:SF10 MITOCHONDRIAL RIBOSOME PROTEIN L39/PROLYL-TRNA LIGASE FAMILY MEMBER PROLINE--TRNA LIGASE, MITOCHONDRIAL-RELATED catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a tRNA#GO:0140101;ligase activity#GO:0016874;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640 macromolecule metabolic process#GO:0043170;amino acid activation#GO:0043038;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;gene expression#GO:0010467;tRNA aminoacylation for protein translation#GO:0006418;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;tRNA aminoacylation#GO:0043039;protein metabolic process#GO:0019538;RNA metabolic process#GO:0016070;translation#GO:0006412;protein biosynthetic process#GO:0160307;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 translational protein#PC00263;aminoacyl-tRNA synthetase#PC00047 HUMAN|HGNC=19072|UniProtKB=Q96J01 Q96J01 THOC3 PTHR22839:SF0 THO COMPLEX SUBUNIT 3 THO3 THO COMPLEX SUBUNIT 3 RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907;metabolic process#GO:0008152;transport#GO:0006810;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;nitrogen compound transport#GO:0071705;macromolecule localization#GO:0033036;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleocytoplasmic transport#GO:0006913;cellular localization#GO:0051641;nucleic acid transport#GO:0050657;mRNA export from nucleus#GO:0006406;localization#GO:0051179;nuclear export#GO:0051168;nuclear transport#GO:0051169;RNA transport#GO:0050658;RNA localization#GO:0006403;nucleobase-containing compound transport#GO:0015931;establishment of RNA localization#GO:0051236;mRNA transport#GO:0051028 organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;THO complex#GO:0000347;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;transcription export complex#GO:0000346;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031 HUMAN|HGNC=30173|UniProtKB=Q9HAS0 Q9HAS0 C17orf75 PTHR14416:SF2 PROTEIN NJMU-R1 PROTEIN NJMU-R1 trans-Golgi network#GO:0005802;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;Golgi apparatus subcompartment#GO:0098791;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794 HUMAN|HGNC=13927|UniProtKB=Q6UXA7 Q6UXA7 C6orf15 PTHR15817:SF2 STG PROTEIN SIMILAR TO HUMAN CHROMOSOME 6 OPEN READING FRAME 15 HUMAN|HGNC=1986|UniProtKB=Q99966 Q99966 CITED1 PTHR17045:SF6 MELANOCYTE SPECIFIC GENE RELATED CITED CBP_P300-INTERACTING TRANSACTIVATOR 1 transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;transcription coactivator activity#GO:0003713 regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;pigmentation#GO:0043473;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;response to chemical#GO:0042221;positive regulation of macromolecule metabolic process#GO:0010604;melanocyte differentiation#GO:0030318;cellular process#GO:0009987;developmental pigmentation#GO:0048066;positive regulation of biological process#GO:0048518;response to hormone#GO:0009725;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;cell differentiation#GO:0030154;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 TGF-beta signaling pathway#P00052>Co-activators corepressors#P01282 HUMAN|HGNC=18386|UniProtKB=Q6UW10 Q6UW10 SFTA2 PTHR38500:SF1 SURFACTANT-ASSOCIATED PROTEIN 2 SURFACTANT-ASSOCIATED PROTEIN 2 surfactant#PC00212;structural protein#PC00211 HUMAN|HGNC=13370|UniProtKB=Q9NXJ0 Q9NXJ0 MS4A12 PTHR23320:SF72 MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 12 cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227 HUMAN|HGNC=15769|UniProtKB=Q9NPB1 Q9NPB1 NT5M PTHR16504:SF6 5'(3')-DEOXYRIBONUCLEOTIDASE 5'(3')-DEOXYRIBONUCLEOTIDASE, MITOCHONDRIAL 5'-nucleotidase activity#GO:0008253;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;nucleotidase activity#GO:0008252;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578 nucleobase-containing small molecule metabolic process#GO:0055086;nucleotide catabolic process#GO:0009166;metabolic process#GO:0008152;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;pyrimidine-containing compound metabolic process#GO:0072527;carbohydrate derivative metabolic process#GO:1901135;organophosphate metabolic process#GO:0019637;nucleobase-containing compound catabolic process#GO:0034655;organophosphate catabolic process#GO:0046434;nucleotide metabolic process#GO:0009117;nucleoside phosphate metabolic process#GO:0006753;carbohydrate derivative catabolic process#GO:1901136;nucleoside phosphate catabolic process#GO:1901292;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793 HUMAN|HGNC=9302|UniProtKB=P30153 P30153 PPP2R1A PTHR10648:SF2 SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 65 KDA REGULATORY SUBUNIT A ALPHA ISOFORM structural molecule activity#GO:0005198;protein complex scaffold activity#GO:0140378 cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;cell cycle#GO:0007049;cell cycle process#GO:0022402;sister chromatid cohesion#GO:0007062;microtubule cytoskeleton organization#GO:0000226;organelle assembly#GO:0070925;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;spindle assembly#GO:0051225;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;chromosome organization#GO:0051276;microtubule-based process#GO:0007017;meiotic sister chromatid cohesion#GO:0051177;chromosome segregation#GO:0007059 catalytic complex#GO:1902494;protein serine/threonine phosphatase complex#GO:0008287;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 phosphatase modulator#PC00184 FGF signaling pathway#P00021>PP2A#P00629 HUMAN|HGNC=9218|UniProtKB=Q01851 Q01851 POU4F1 PTHR11636:SF42 POU DOMAIN POU DOMAIN, CLASS 4, TRANSCRIPTION FACTOR 1 RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=22043|UniProtKB=Q8N859 Q8N859 ZNF713 PTHR24384:SF80 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED ZINC FINGER PROTEIN 713 RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218 HUMAN|HGNC=9380|UniProtKB=P17612 P17612 PRKACA PTHR24353:SF162 CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;renal system process#GO:0003014;cellular process#GO:0009987;signal transduction#GO:0007165;system process#GO:0003008;renal absorption#GO:0070293;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189 transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;transferase complex#GO:1990234;protein kinase complex#GO:1902911;intracellular protein-containing complex#GO:0140535;cytosol#GO:0005829;nucleus#GO:0005634;protein-containing complex#GO:0032991;cytoplasm#GO:0005737 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 Metabotropic glutamate receptor group II pathway#P00040>PKA#P01050;5HT1 type receptor mediated signaling pathway#P04373>PKA#P04403;Enkephalin release#P05913>PKA#P05972;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>PKA#P01075;Histamine H2 receptor mediated signaling pathway#P04386>PKA#P04491;CCKR signaling map#P06959>PKA-Calpha/beta/gamma#P07099;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>PKA-c#P00707;Dopamine receptor mediated signaling pathway#P05912>PKA#P05946;GABA-B receptor II signaling#P05731>PKA#P05752;Beta2 adrenergic receptor signaling pathway#P04378>PKA#P04444;Endothelin signaling pathway#P00019>PKA#P00570;Metabotropic glutamate receptor group III pathway#P00039>PKA#P01035;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>PKA#P00746;Beta1 adrenergic receptor signaling pathway#P04377>PKA#P04437;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PKA#P00862;Metabotropic glutamate receptor group I pathway#P00041>PKA#P01059;Nicotine pharmacodynamics pathway#P06587>PRKACA#P06588 HUMAN|HGNC=11473|UniProtKB=Q13503 Q13503 MED21 PTHR13381:SF1 RNA POLYMERASE II HOLOENZYME COMPONENT SRB7 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21 transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;mediator complex#GO:0016592;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 DNA-directed RNA polymerase#PC00019;RNA metabolism protein#PC00031 HUMAN|HGNC=15564|UniProtKB=Q9NZH7 Q9NZH7 IL36B PTHR10078:SF24 INTERLEUKIN-1 FAMILY MEMBER INTERLEUKIN-36 BETA molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;cytokine activity#GO:0005125 response to molecule of bacterial origin#GO:0002237;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;positive regulation of multicellular organismal process#GO:0051240;response to stimulus#GO:0050896;cellular response to chemical stimulus#GO:0070887;immune system process#GO:0002376;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987;response to biotic stimulus#GO:0009607;positive regulation of immune system process#GO:0002684;positive regulation of cell development#GO:0010720;cellular response to lipid#GO:0071396;positive regulation of cell differentiation#GO:0045597;response to lipopolysaccharide#GO:0032496;cellular response to stimulus#GO:0051716;cellular response to biotic stimulus#GO:0071216;regulation of cell-cell adhesion#GO:0022407;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;cytokine-mediated signaling pathway#GO:0019221;positive regulation of lymphocyte activation#GO:0051251;positive regulation of cellular process#GO:0048522;immune response#GO:0006955;regulation of cell development#GO:0060284;positive regulation of leukocyte cell-cell adhesion#GO:1903039;biological regulation#GO:0065007;positive regulation of cell activation#GO:0050867;regulation of cell adhesion#GO:0030155;positive regulation of developmental process#GO:0051094;regulation of cell differentiation#GO:0045595;defense response#GO:0006952;regulation of cell activation#GO:0050865;regulation of multicellular organismal development#GO:2000026;regulation of leukocyte activation#GO:0002694;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;regulation of lymphocyte activation#GO:0051249;response to oxygen-containing compound#GO:1901700;response to peptide#GO:1901652;positive regulation of cell-cell adhesion#GO:0022409;response to stress#GO:0006950;cellular response to lipopolysaccharide#GO:0071222;regulation of multicellular organismal process#GO:0051239;positive regulation of T cell activation#GO:0050870;response to chemical#GO:0042221;response to cytokine#GO:0034097;regulation of T cell activation#GO:0050863;response to lipid#GO:0033993;positive regulation of leukocyte activation#GO:0002696;cell surface receptor signaling pathway#GO:0007166;positive regulation of cell adhesion#GO:0045785;regulation of developmental process#GO:0050793;response to external biotic stimulus#GO:0043207;inflammatory response#GO:0006954;response to bacterium#GO:0009617;cell communication#GO:0007154;regulation of hemopoiesis#GO:1903706;response to other organism#GO:0051707;regulation of leukocyte cell-cell adhesion#GO:1903037;response to external stimulus#GO:0009605;cellular response to molecule of bacterial origin#GO:0071219 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207;cytokine#PC00083;interleukin superfamily#PC00128 HUMAN|HGNC=16114|UniProtKB=Q9BTX7 Q9BTX7 TTPAL PTHR10174:SF130 ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED ALPHA-TOCOPHEROL TRANSFER PROTEIN-LIKE small molecule binding#GO:0036094;anion binding#GO:0043168;binding#GO:0005488;ion binding#GO:0043167;phosphatidylinositol bisphosphate binding#GO:1902936 transfer/carrier protein#PC00219 HUMAN|HGNC=27034|UniProtKB=Q8N434 Q8N434 SVOPL PTHR24064:SF457 SOLUTE CARRIER FAMILY 22 MEMBER TRANSPORTER SVOPL-RELATED transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 cellular process#GO:0009987;transport#GO:0006810;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258 HUMAN|HGNC=26764|UniProtKB=P0DUQ1 P0DUQ1 PRAMEF15 PTHR14224:SF112 SIMILAR TO PREFERENTIALLY EXPRESSED ANTIGEN IN MELANOMA-LIKE 3 PRAME FAMILY MEMBER 11-RELATED ubiquitin-like ligase-substrate adaptor activity#GO:1990756;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;enzyme-substrate adaptor activity#GO:0140767 ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238 ubiquitin ligase complex#GO:0000151;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;transferase complex#GO:1990234;catalytic complex#GO:1902494;Cul2-RING ubiquitin ligase complex#GO:0031462;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cullin-RING ubiquitin ligase complex#GO:0031461;cytoplasm#GO:0005737 HUMAN|HGNC=5952|UniProtKB=Q9NSI5 Q9NSI5 IGSF5 PTHR44991:SF1 IMMUNOGLOBULIN SUPERFAMILY MEMBER 5 IMMUNOGLOBULIN SUPERFAMILY MEMBER 5 cell-cell adhesion#GO:0098609;cellular process#GO:0009987;cell adhesion#GO:0007155 apical junction complex#GO:0043296;tight junction#GO:0070160;cell junction#GO:0030054;anchoring junction#GO:0070161;cell-cell junction#GO:0005911;cellular anatomical structure#GO:0110165;bicellular tight junction#GO:0005923;cell surface#GO:0009986 immunoglobulin#PC00123 HUMAN|HGNC=1833|UniProtKB=P49715 P49715 CEBPA PTHR23334:SF5 CCAAT/ENHANCER BINDING PROTEIN CCAAT_ENHANCER-BINDING PROTEIN ALPHA RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA-binding transcription factor#PC00218;basic leucine zipper transcription factor#PC00056 HUMAN|HGNC=35155|UniProtKB=Q7Z2Q7 Q7Z2Q7 LRRC70 PTHR45617:SF121 LEUCINE RICH REPEAT FAMILY PROTEIN LEUCINE-RICH REPEAT-CONTAINING PROTEIN 70 scaffold/adaptor protein#PC00226 HUMAN|HGNC=29102|UniProtKB=A0JNW5 A0JNW5 BLTP3B PTHR22774:SF17 CHOREIN N-TERMINAL DOMAIN-CONTAINING PROTEIN BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 3B transporter activity#GO:0005215;molecular carrier activity#GO:0140104;lipid carrier activity#GO:0005319;lipid transfer activity#GO:0120013 cytosolic transport#GO:0016482;cellular component organization#GO:0016043;cellular localization#GO:0051641;localization#GO:0051179;lipid localization#GO:0010876;membrane organization#GO:0061024;vesicle-mediated transport#GO:0016192;lipid transport#GO:0006869;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;macromolecule localization#GO:0033036;retrograde transport, endosome to Golgi#GO:0042147;endosomal transport#GO:0016197;establishment of localization#GO:0051234;intermembrane lipid transfer#GO:0120009;cellular component organization or biogenesis#GO:0071840;Golgi vesicle transport#GO:0048193;transport#GO:0006810;intracellular transport#GO:0046907 intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=20803|UniProtKB=Q96K37 Q96K37 SLC35E1 PTHR11132:SF427 SOLUTE CARRIER FAMILY 35 SOLUTE CARRIER FAMILY 35 MEMBER E1 antiporter activity#GO:0015297;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804 transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810;cellular process#GO:0009987 Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 secondary carrier transporter#PC00258;transporter#PC00227 HUMAN|HGNC=11786|UniProtKB=P35442 P35442 THBS2 PTHR10199:SF10 THROMBOSPONDIN THROMBOSPONDIN-2 extracellular matrix structural constituent#GO:0005201;structural molecule activity#GO:0005198 regulation of multicellular organismal development#GO:2000026;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of multicellular organismal process#GO:0051241;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;regulation of developmental process#GO:0050793;regulation of vasculature development#GO:1901342;regulation of angiogenesis#GO:0045765;negative regulation of angiogenesis#GO:0016525;regulation of anatomical structure morphogenesis#GO:0022603 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012 cell adhesion molecule#PC00069 HUMAN|HGNC=34386|UniProtKB=Q6UXP3 Q6UXP3 TMEM14EP PTHR12668:SF4 TRANSMEMBRANE PROTEIN 14, 15 TRANSMEMBRANE PROTEIN 14C-RELATED biosynthetic process#GO:0009058;heme metabolic process#GO:0042168;tetrapyrrole biosynthetic process#GO:0033014;cellular process#GO:0009987;pigment metabolic process#GO:0042440;heme biosynthetic process#GO:0006783;porphyrin-containing compound biosynthetic process#GO:0006779;porphyrin-containing compound metabolic process#GO:0006778;pigment biosynthetic process#GO:0046148;metabolic process#GO:0008152;tetrapyrrole metabolic process#GO:0033013 intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;organelle envelope#GO:0031967;mitochondrial envelope#GO:0005740;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966 HUMAN|HGNC=16265|UniProtKB=Q9H1J7 Q9H1J7 WNT5B PTHR12027:SF87 WNT RELATED PROTEIN WNT-5B molecular function activator activity#GO:0140677;protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102;cytokine activity#GO:0005125;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;G protein-coupled receptor binding#GO:0001664;frizzled binding#GO:0005109;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018 regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;Wnt signaling pathway#GO:0016055;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;signaling#GO:0023052;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;canonical Wnt signaling pathway#GO:0060070;cell communication#GO:0007154;anatomical structure development#GO:0048856;cell fate commitment#GO:0045165;system development#GO:0048731;signal transduction#GO:0007165;cellular process#GO:0009987;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;nervous system development#GO:0007399;developmental process#GO:0032502;neuron differentiation#GO:0030182;cell surface receptor signaling pathway#GO:0007166;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;neurogenesis#GO:0022008 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 Cadherin signaling pathway#P00012>Wnt#P00474;Angiogenesis#P00005>Wnt#P00206;Alzheimer disease-presenilin pathway#P00004>Wnt#P00142;Wnt signaling pathway#P00057>Wnt#P01444 HUMAN|HGNC=26353|UniProtKB=Q86VV4 Q86VV4 RANBP3L PTHR23138:SF88 RAN BINDING PROTEIN RAN-BINDING PROTEIN 3-LIKE nucleocytoplasmic transport#GO:0006913;protein transport#GO:0015031;nuclear export#GO:0051168;nuclear transport#GO:0051169;cellular localization#GO:0051641;localization#GO:0051179;intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;macromolecule localization#GO:0033036;protein export from nucleus#GO:0006611 organelle envelope#GO:0031967;nucleus#GO:0005634;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;nuclear pore#GO:0005643;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HUMAN|HGNC=11365|UniProtKB=Q14765 Q14765 STAT4 PTHR11801:SF19 SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 4 nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 cell surface receptor signaling pathway#GO:0007166;cell surface receptor signaling pathway via STAT#GO:0097696;response to cytokine#GO:0034097;response to chemical#GO:0042221;signal transduction#GO:0007165;cellular process#GO:0009987;response to hormone#GO:0009725;response to stress#GO:0006950;response to peptide#GO:1901652;response to oxygen-containing compound#GO:1901700;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;defense response#GO:0006952;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cell surface receptor signaling pathway via JAK-STAT#GO:0007259;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;response to peptide hormone#GO:0043434;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;response to nitrogen compound#GO:1901698;regulation of RNA metabolic process#GO:0051252;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;regulation of DNA-templated transcription#GO:0006355;cytokine-mediated signaling pathway#GO:0019221;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716 nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513 immunoglobulin fold transcription factor#PC00251;Rel homology transcription factor#PC00252 Interleukin signaling pathway#P00036>STAT#P00996;PDGF signaling pathway#P00047>STAT#P01173;EGF receptor signaling pathway#P00018>STAT#P00561;JAK/STAT signaling pathway#P00038>STAT#P01027 HUMAN|HGNC=11787|UniProtKB=P49746 P49746 THBS3 PTHR10199:SF89 THROMBOSPONDIN THROMBOSPONDIN-3 structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 cell adhesion molecule#PC00069 HUMAN|HGNC=16667|UniProtKB=Q9NV96 Q9NV96 TMEM30A PTHR10926:SF17 CELL CYCLE CONTROL PROTEIN 50 CELL CYCLE CONTROL PROTEIN 50A enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 transport#GO:0006810;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;regulation of membrane lipid distribution#GO:0097035;macromolecule localization#GO:0033036;cellular process#GO:0009987;lipid transport#GO:0006869;biological regulation#GO:0065007;phospholipid transport#GO:0015914;membrane organization#GO:0061024;phospholipid translocation#GO:0045332;lipid localization#GO:0010876;localization#GO:0051179;regulation of biological quality#GO:0065008;cellular component organization#GO:0016043;organophosphate ester transport#GO:0015748;lipid translocation#GO:0034204 plasma membrane#GO:0005886;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;Golgi apparatus#GO:0005794 HUMAN|HGNC=12765|UniProtKB=O15353 O15353 FOXN1 PTHR46721:SF1 FORKHEAD BOX PROTEIN N1 FORKHEAD BOX PROTEIN N1 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 gene-specific transcriptional regulator#PC00264;winged helix/forkhead transcription factor#PC00246;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=28927|UniProtKB=Q3SY84 Q3SY84 KRT71 PTHR45616:SF16 GATA-TYPE DOMAIN-CONTAINING PROTEIN KERATIN, TYPE II CYTOSKELETAL 71 structural molecule activity#GO:0005198 intermediate filament organization#GO:0045109;intermediate filament-based process#GO:0045103;keratinocyte differentiation#GO:0030216;animal gross anatomical part developmental process#GO:0160108;supramolecular fiber organization#GO:0097435;anatomical structure development#GO:0048856;cellular component organization#GO:0016043;intermediate filament cytoskeleton organization#GO:0045104;cell differentiation#GO:0030154;developmental process#GO:0032502;epidermis development#GO:0008544;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;animal organ development#GO:0048513;cellular process#GO:0009987;organelle organization#GO:0006996;skin development#GO:0043588;cytoskeleton organization#GO:0007010;epithelium development#GO:0060429;multicellular organismal process#GO:0032501;epidermal cell differentiation#GO:0009913;epithelial cell differentiation#GO:0030855;tissue development#GO:0009888 organelle#GO:0043226;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;intermediate filament#GO:0005882;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=6477|UniProtKB=Q6GTX8 Q6GTX8 LAIR1 PTHR11738:SF129 MHC CLASS I NK CELL RECEPTOR LEUKOCYTE-ASSOCIATED IMMUNOGLOBULIN-LIKE RECEPTOR 1-RELATED signaling receptor activity#GO:0038023;immune receptor activity#GO:0140375;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 immune response-regulating signaling pathway#GO:0002764;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166;regulation of immune response#GO:0050776;cell communication#GO:0007154 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=29937|UniProtKB=Q8IXS2 Q8IXS2 DRC2 PTHR21625:SF0 NYD-SP28 PROTEIN DYNEIN REGULATORY COMPLEX SUBUNIT 2 cellular component organization#GO:0016043;cilium assembly#GO:0060271;protein-containing complex assembly#GO:0065003;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;cell motility#GO:0048870;cell projection organization#GO:0030030;regulation of microtubule-based movement#GO:0060632;regulation of microtubule-based process#GO:0032886;organelle assembly#GO:0070925;microtubule bundle formation#GO:0001578;axonemal dynein complex assembly#GO:0070286;cilium or flagellum-dependent cell motility#GO:0001539;microtubule cytoskeleton organization#GO:0000226;cilium-dependent cell motility#GO:0060285;cilium organization#GO:0044782;axoneme assembly#GO:0035082;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection assembly#GO:0120031;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;microtubule-based process#GO:0007017 organelle#GO:0043226;cellular anatomical structure#GO:0110165;ciliary plasm#GO:0097014;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;cytoskeleton#GO:0005856;cilium#GO:0005929;intracellular organelle#GO:0043229;axoneme#GO:0005930;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=7765|UniProtKB=P21359 P21359 NF1 PTHR10194:SF142 RAS GTPASE-ACTIVATING PROTEINS NEUROFIBROMIN GTPase-activating protein#PC00257 EGF receptor signaling pathway#P00018>GAP#P00546 HUMAN|HGNC=31297|UniProtKB=A6NDL8 A6NDL8 OR6C68 PTHR26454:SF19 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 6C68 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=11102|UniProtKB=Q9NZC9 Q9NZC9 SMARCAL1 PTHR45766:SF6 DNA ANNEALING HELICASE AND ENDONUCLEASE ZRANB3 FAMILY MEMBER SNF2 RELATED CHROMATIN REMODELING ANNEALING HELICASE 1 nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543;catalytic activity, acting on DNA#GO:0140097;helicase activity#GO:0004386;DNA helicase activity#GO:0003678;isomerase activity#GO:0016853;nucleic acid binding#GO:0003676;binding#GO:0005488;ATP-dependent activity#GO:0140657;single-stranded DNA binding#GO:0003697;ATP-dependent activity, acting on DNA#GO:0008094;DNA binding#GO:0003677 cellular process#GO:0009987;response to stress#GO:0006950;replication fork processing#GO:0031297;nucleobase-containing compound metabolic process#GO:0006139;DNA damage response#GO:0006974;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular response to stimulus#GO:0051716;DNA replication#GO:0006260;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;DNA-templated DNA replication#GO:0006261 nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membraneless organelle#GO:0043228;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;chromosome#GO:0005694;replication fork#GO:0005657;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear replication fork#GO:0043596;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 DNA metabolism protein#PC00009 Wnt signaling pathway#P00057>SWI/SNF#P01435 HUMAN|HGNC=11251|UniProtKB=Q08629 Q08629 SPOCK1 PTHR13866:SF17 SPARC OSTEONECTIN TESTICAN-1 cation binding#GO:0043169;molecular function inhibitor activity#GO:0140678;metal ion binding#GO:0046872;enzyme regulator activity#GO:0030234;peptidase regulator activity#GO:0061134;calcium ion binding#GO:0005509;peptidase inhibitor activity#GO:0030414;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;endopeptidase regulator activity#GO:0061135;molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866;enzyme inhibitor activity#GO:0004857 regulation of biological process#GO:0050789;biological regulation#GO:0065007;regulation of cell-substrate adhesion#GO:0010810;regulation of cellular process#GO:0050794;regulation of cell adhesion#GO:0030155 extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cellular anatomical structure#GO:0110165 extracellular matrix protein#PC00102;extracellular matrix glycoprotein#PC00100 HUMAN|HGNC=24563|UniProtKB=Q9Y421 Q9Y421 FAM32A PTHR13282:SF10 PROTEIN FAM32A PROTEIN FAM32A nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;spliceosomal complex#GO:0005681;organelle lumen#GO:0043233;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=12004|UniProtKB=Q13641 Q13641 TPBG PTHR24364:SF17 LP06937P TROPHOBLAST GLYCOPROTEIN regulation of canonical Wnt signaling pathway#GO:0060828;negative regulation of Wnt signaling pathway#GO:0030178;negative regulation of response to stimulus#GO:0048585;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of signal transduction#GO:0009968;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111;negative regulation of canonical Wnt signaling pathway#GO:0090090;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;negative regulation of cell communication#GO:0010648 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 HUMAN|HGNC=17818|UniProtKB=Q96P26 Q96P26 NT5C1B PTHR31367:SF0 CYTOSOLIC 5'-NUCLEOTIDASE 1 FAMILY MEMBER CYTOSOLIC 5'-NUCLEOTIDASE 1B phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;5'-nucleotidase activity#GO:0008253;nucleotidase activity#GO:0008252;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791 metabolic process#GO:0008152;purine nucleoside metabolic process#GO:0042278;nucleobase-containing small molecule metabolic process#GO:0055086;primary metabolic process#GO:0044238;cellular process#GO:0009987;purine-containing compound metabolic process#GO:0072521;adenosine metabolic process#GO:0046085;carbohydrate derivative metabolic process#GO:1901135;nucleoside metabolic process#GO:0009116;small molecule metabolic process#GO:0044281;nucleobase-containing compound metabolic process#GO:0006139 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=21624|UniProtKB=Q9NSK0 Q9NSK0 KLC4 PTHR45783:SF6 KINESIN LIGHT CHAIN KINESIN LIGHT CHAIN 4 cytoskeletal protein binding#GO:0008092;binding#GO:0005488;protein binding#GO:0005515 microtubule-based process#GO:0007017;microtubule-based movement#GO:0007018;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 microtubule binding motor protein#PC00156 Alzheimer disease-amyloid secretase pathway#P00003>kinesin#P00107 HUMAN|HGNC=28114|UniProtKB=Q8IZ83 Q8IZ83 ALDH16A1 PTHR11699:SF211 ALDEHYDE DEHYDROGENASE-RELATED ALDEHYDE DEHYDROGENASE FAMILY 16 MEMBER A1 catalytic activity#GO:0003824;oxidoreductase activity, acting on the aldehyde or oxo group of donors#GO:0016903;aldehyde dehydrogenase (NAD+) activity#GO:0004029;oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor#GO:0016620;oxidoreductase activity#GO:0016491 metabolite interconversion enzyme#PC00262;dehydrogenase#PC00092 5-Hydroxytryptamine degredation#P04372>Aldehyde Dehydrogenase#P04402 HUMAN|HGNC=15346|UniProtKB=Q8NGC1 Q8NGC1 OR11G2 PTHR24242:SF183 G-PROTEIN COUPLED RECEPTOR OLFACTORY RECEPTOR 11G2 G-protein coupled receptor#PC00021 HUMAN|HGNC=1047|UniProtKB=Q93088 Q93088 BHMT PTHR46120:SF2 BETAINE--HOMOCYSTEINE S-METHYLTRANSFERASE 1 BETAINE--HOMOCYSTEINE S-METHYLTRANSFERASE 1 transferase activity, transferring one-carbon groups#GO:0016741;methyltransferase activity#GO:0008168;transferase activity#GO:0016740;catalytic activity#GO:0003824 carboxylic acid biosynthetic process#GO:0046394;cellular process#GO:0009987;aspartate family amino acid biosynthetic process#GO:0009067;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;sulfur compound metabolic process#GO:0006790;biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;small molecule metabolic process#GO:0044281;proteinogenic amino acid metabolic process#GO:0170039;small molecule biosynthetic process#GO:0044283;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;amino acid biosynthetic process#GO:0008652;proteinogenic amino acid biosynthetic process#GO:0170038 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 methyltransferase#PC00155 HUMAN|HGNC=24176|UniProtKB=Q6UXG8 Q6UXG8 BTNL9 PTHR24100:SF162 BUTYROPHILIN BUTYROPHILIN-LIKE PROTEIN 9 binding#GO:0005488;signaling receptor binding#GO:0005102;protein binding#GO:0005515 immune response-regulating signaling pathway#GO:0002764;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signaling#GO:0023052;immune system process#GO:0002376;positive regulation of immune system process#GO:0002684;cellular process#GO:0009987;signal transduction#GO:0007165;activation of immune response#GO:0002253;positive regulation of biological process#GO:0048518;antigen receptor-mediated signaling pathway#GO:0050851;regulation of multicellular organismal process#GO:0051239;cell surface receptor signaling pathway#GO:0007166;immune response-activating signaling pathway#GO:0002757;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of macromolecule metabolic process#GO:0060255;immune response-activating cell surface receptor signaling pathway#GO:0002429;regulation of immune response#GO:0050776;cell communication#GO:0007154;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cytokine production#GO:0001817;positive regulation of response to stimulus#GO:0048584;immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007;T cell receptor signaling pathway#GO:0050852;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 membrane#GO:0016020;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell surface#GO:0009986;plasma membrane#GO:0005886 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=40041|UniProtKB=C9J6K1 C9J6K1 C19orf81 PTHR37153:SF1 CHROMOSOME 19 C19ORF81 HOMOLOG SIMLAR TO HUMAN CHROMOSOME 19 OPEN READING FRAME 81 HUMAN|HGNC=29423|UniProtKB=Q8N782 Q8N782 ZNF525 PTHR23232:SF178 KRAB DOMAIN C2H2 ZINC FINGER KRAB DOMAIN-CONTAINING PROTEIN 5-RELATED DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=5892|UniProtKB=A0A075B6J2 A0A075B6J2 IGLV2-33 PTHR23267:SF491 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN LAMBDA VARIABLE 2-18-RELATED immune response#GO:0006955;immune system process#GO:0002376;response to stimulus#GO:0050896 protein-containing complex#GO:0032991 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=30879|UniProtKB=Q969R8 Q969R8 ITFG2 PTHR16317:SF1 INTEGRIN ALPHA REPEAT DOMAIN-CONTAINING KICSTOR COMPLEX PROTEIN ITFG2 regulation of TORC1 signaling#GO:1903432;cellular response to nutrient levels#GO:0031669;negative regulation of TORC1 signaling#GO:1904262;regulation of response to stimulus#GO:0048583;cellular response to starvation#GO:0009267;negative regulation of cellular process#GO:0048523;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;cellular response to amino acid starvation#GO:0034198;negative regulation of response to stimulus#GO:0048585;cellular process#GO:0009987;regulation of TOR signaling#GO:0032006;response to nutrient levels#GO:0031667;response to stress#GO:0006950;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;cellular response to stress#GO:0033554;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;regulation of cell communication#GO:0010646;negative regulation of TOR signaling#GO:0032007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;negative regulation of biological process#GO:0048519;response to starvation#GO:0042594 protein-containing complex#GO:0032991 integrin#PC00126 HUMAN|HGNC=14104|UniProtKB=Q5BKZ1 Q5BKZ1 ZNF326 PTHR12190:SF1 A-KINASE ANCHOR PROTEIN AKAP 8 DBIRD COMPLEX SUBUNIT ZNF326 regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription elongation#GO:0032784 intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634 scaffold/adaptor protein#PC00226 HUMAN|HGNC=13208|UniProtKB=Q9H9E1 Q9H9E1 ANKRA2 PTHR24124:SF3 ANKYRIN REPEAT FAMILY A ANKYRIN REPEAT FAMILY A PROTEIN 2 regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 protein-binding activity modulator#PC00095 HUMAN|HGNC=9700|UniProtKB=Q8IVU1 Q8IVU1 IGDCC3 PTHR10075:SF123 BASIGIN RELATED IMMUNOGLOBULIN SUPERFAMILY DCC SUBCLASS MEMBER 3 cell adhesion molecule#PC00069 HUMAN|HGNC=25272|UniProtKB=Q8TBB5 Q8TBB5 KLHDC4 PTHR46063:SF1 KELCH DOMAIN-CONTAINING PROTEIN KELCH DOMAIN-CONTAINING PROTEIN 4 HUMAN|HGNC=22212|UniProtKB=Q9ULE3 Q9ULE3 DENND2A PTHR15288:SF3 DENN DOMAIN-CONTAINING PROTEIN 2 DENN DOMAIN-CONTAINING PROTEIN 2A guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234 transport#GO:0006810;intracellular transport#GO:0046907;endosomal transport#GO:0016197;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;retrograde transport, endosome to Golgi#GO:0042147;cytosolic transport#GO:0016482;vesicle-mediated transport#GO:0016192 actin cytoskeleton#GO:0015629;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=13907|UniProtKB=Q8N100 Q8N100 ATOH7 PTHR19290:SF99 BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED TRANSCRIPTION FACTOR ATOH7 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;developmental process#GO:0032502;sensory organ development#GO:0007423;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;neuron fate commitment#GO:0048663;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;axon development#GO:0061564;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;plasma membrane bounded cell projection organization#GO:0120036;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cell fate commitment#GO:0045165;neuron development#GO:0048666;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;cell development#GO:0048468;cell projection organization#GO:0030030;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;neuron differentiation#GO:0030182;positive regulation of transcription by RNA polymerase II#GO:0045944;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;animal organ development#GO:0048513;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;neuron projection development#GO:0031175;nervous system development#GO:0007399;positive regulation of macromolecule metabolic process#GO:0010604 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=33188|UniProtKB=Q6UX39 Q6UX39 AMTN PTHR36858:SF1 AMELOTIN AMELOTIN HUMAN|HGNC=4844|UniProtKB=P14317 P14317 HCLS1 PTHR10829:SF5 CORTACTIN AND DREBRIN HEMATOPOIETIC LINEAGE CELL-SPECIFIC PROTEIN actin filament binding#GO:0051015;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 regulation of actin polymerization or depolymerization#GO:0008064;biological regulation#GO:0065007;regulation of actin cytoskeleton organization#GO:0032956;regulation of actin filament polymerization#GO:0030833;cell migration#GO:0016477;regulation of actin filament organization#GO:0110053;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;regulation of anatomical structure size#GO:0090066;regulation of actin filament-based process#GO:0032970;regulation of cellular component biogenesis#GO:0044087;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;regulation of protein polymerization#GO:0032271;cell motility#GO:0048870;regulation of cellular process#GO:0050794;regulation of supramolecular fiber organization#GO:1902903;regulation of cellular component size#GO:0032535;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;regulation of protein-containing complex assembly#GO:0043254;cellular component organization#GO:0016043;regulation of biological quality#GO:0065008;regulation of actin filament length#GO:0030832 supramolecular fiber#GO:0099512;site of polarized growth#GO:0030427;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;actin cytoskeleton#GO:0015629;cortical cytoskeleton#GO:0030863;cell cortex#GO:0005938;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cytoskeleton#GO:0005856;actin filament#GO:0005884;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;cytoplasm#GO:0005737;cortical actin cytoskeleton#GO:0030864;membrane#GO:0016020;cell periphery#GO:0071944 non-motor actin binding protein#PC00165;cytoskeletal protein#PC00085 HUMAN|HGNC=23518|UniProtKB=Q96BP2 Q96BP2 CHCHD1 PTHR31278:SF2 CHCHD1 SMALL RIBOSOMAL SUBUNIT PROTEIN MS37 HUMAN|HGNC=16063|UniProtKB=P55197 P55197 MLLT10 PTHR13793:SF93 PHD FINGER PROTEINS PROTEIN AF-10 chromatin-protein adaptor activity#GO:0140463;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;histone reader activity#GO:0140566 regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;chromatin remodeling#GO:0006338;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;chromatin organization#GO:0006325;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 gene-specific transcriptional regulator#PC00264;zinc finger transcription factor#PC00244 HUMAN|HGNC=18625|UniProtKB=Q9NWM8 Q9NWM8 FKBP14 PTHR46222:SF1 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP7/14 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP14 chaperone#PC00072 HUMAN|HGNC=1125|UniProtKB=P20290 P20290 BTF3 PTHR10351:SF28 TRANSCRIPTION FACTOR BTF3 FAMILY MEMBER TRANSCRIPTION FACTOR BTF3 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 DNA-binding transcription factor#PC00218 HUMAN|HGNC=17432|UniProtKB=Q9BZP6 Q9BZP6 CHIA PTHR11177:SF188 CHITINASE ACIDIC MAMMALIAN CHITINASE hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;chitinase activity#GO:0004568;catalytic activity#GO:0003824;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553 cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;carbohydrate derivative catabolic process#GO:1901136;amino sugar metabolic process#GO:0006040;catabolic process#GO:0009056;chitin metabolic process#GO:0006030;macromolecule catabolic process#GO:0009057;aminoglycan metabolic process#GO:0006022;metabolic process#GO:0008152;chitin catabolic process#GO:0006032;aminoglycan catabolic process#GO:0006026;amino sugar catabolic process#GO:0046348;macromolecule metabolic process#GO:0043170 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 metabolite interconversion enzyme#PC00262;glycosidase#PC00110 HUMAN|HGNC=25726|UniProtKB=Q9Y4W2 Q9Y4W2 LAS1L PTHR15002:SF0 RIBOSOMAL BIOGENESIS PROTEIN LAS1L RIBOSOMAL BIOGENESIS PROTEIN LAS1L RNA endonuclease activity#GO:0004521;catalytic activity, acting on RNA#GO:0140098;RNA nuclease activity#GO:0004540;endonuclease activity#GO:0004519;nuclease activity#GO:0004518;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640 metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;maturation of LSU-rRNA#GO:0000470;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;ribosomal large subunit biogenesis#GO:0042273;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;maturation of 5.8S rRNA#GO:0000460;ribonucleoprotein complex biogenesis#GO:0022613 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=16197|UniProtKB=Q96S44 Q96S44 TP53RK PTHR12209:SF0 NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE EKC_KEOPS COMPLEX SUBUNIT TP53RK kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex#GO:1990234;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cytosol#GO:0005829;nucleus#GO:0005634 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=11919|UniProtKB=P25942 P25942 CD40 PTHR46875:SF1 TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 5 TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 5 signaling#GO:0023052;response to stimulus#GO:0050896;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;immune response-regulating signaling pathway#GO:0002764;cellular response to stimulus#GO:0051716;leukocyte activation#GO:0045321;cell communication#GO:0007154;regulation of immune response#GO:0050776;cell activation#GO:0001775;immune system process#GO:0002376;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;lymphocyte activation#GO:0046649;multicellular organismal process#GO:0032501;signal transduction#GO:0007165;cellular process#GO:0009987;B cell activation#GO:0042113;regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166 membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cell surface#GO:0009986;plasma membrane#GO:0005886;signaling receptor complex#GO:0043235;external side of plasma membrane#GO:0009897;side of membrane#GO:0098552 transmembrane signal receptor#PC00197 HUMAN|HGNC=12477|UniProtKB=P51965 P51965 UBE2E1 PTHR24068:SF70 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2 E1 ubiquitin-like protein conjugating enzyme activity#GO:0061650;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity, acting on a protein#GO:0140096;ubiquitin conjugating enzyme activity#GO:0061631;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824 macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152;protein K48-linked ubiquitination#GO:0070936;post-translational protein modification#GO:0043687;ISG15-protein conjugation#GO:0032020;protein ubiquitination#GO:0016567;cellular process#GO:0009987;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;protein modification process#GO:0036211;primary metabolic process#GO:0044238 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 ubiquitin-protein ligase#PC00234 Ubiquitin proteasome pathway#P00060>E2#P01491 HUMAN|HGNC=9591|UniProtKB=Q13258 Q13258 PTGDR PTHR11866:SF14 G-PROTEIN COUPLED RECEPTOR FAMILY 1 MEMBER PROSTAGLANDIN D2 RECEPTOR molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 regulation of biological quality#GO:0065008;cell communication#GO:0007154;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;positive regulation of cytosolic calcium ion concentration#GO:0007204;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=9107|UniProtKB=Q9Y4D7 Q9Y4D7 PLXND1 PTHR22625:SF7 PLEXIN PLEXIN-D1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 positive regulation of cellular component organization#GO:0051130;animal gross anatomical part developmental process#GO:0160108;positive regulation of axonogenesis#GO:0050772;regulation of biological quality#GO:0065008;regulation of biological process#GO:0050789;positive regulation of multicellular organismal process#GO:0051240;regulation of multicellular organismal development#GO:2000026;regulation of cell shape#GO:0008360;cell junction assembly#GO:0034329;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;signaling#GO:0023052;positive regulation of nervous system development#GO:0051962;response to stimulus#GO:0050896;regulation of cellular component organization#GO:0051128;synapse assembly#GO:0007416;cell surface receptor signaling pathway#GO:0007166;positive regulation of cell differentiation#GO:0045597;regulation of axonogenesis#GO:0050770;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;regulation of anatomical structure morphogenesis#GO:0022603;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;regulation of neuron projection development#GO:0010975;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;nervous system development#GO:0007399;regulation of multicellular organismal process#GO:0051239;positive regulation of cell development#GO:0010720;cellular component assembly#GO:0022607;synapse organization#GO:0050808;positive regulation of cell projection organization#GO:0031346;system development#GO:0048731;cell communication#GO:0007154;regulation of cell motility#GO:2000145;regulation of nervous system development#GO:0051960;anatomical structure development#GO:0048856;cellular response to stimulus#GO:0051716;regulation of neurogenesis#GO:0050767;regulation of developmental process#GO:0050793;positive regulation of neurogenesis#GO:0050769;regulation of cellular process#GO:0050794;cell junction organization#GO:0034330;positive regulation of developmental process#GO:0051094;developmental process#GO:0032502;regulation of cell migration#GO:0030334;regulation of cell differentiation#GO:0045595;regulation of cell projection organization#GO:0031344;negative regulation of cellular process#GO:0048523;regulation of plasma membrane bounded cell projection organization#GO:0120035;positive regulation of cellular process#GO:0048522;regulation of cell development#GO:0060284;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;negative regulation of cell adhesion#GO:0007162;regulation of cell adhesion#GO:0030155;multicellular organismal process#GO:0032501 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;signaling receptor complex#GO:0043235 transmembrane signal receptor#PC00197 HUMAN|HGNC=7552|UniProtKB=Q13203 Q13203 MYBPH PTHR13817:SF49 TITIN MYOSIN-BINDING PROTEIN H structural molecule activity#GO:0005198 sarcomere organization#GO:0045214;actin filament-based process#GO:0030029;organelle assembly#GO:0070925;animal gross anatomical part developmental process#GO:0160108;cellular component assembly involved in morphogenesis#GO:0010927;supramolecular fiber organization#GO:0097435;striated muscle cell development#GO:0055002;anatomical structure development#GO:0048856;anatomical structure morphogenesis#GO:0009653;muscle cell differentiation#GO:0042692;myofibril assembly#GO:0030239;muscle cell development#GO:0055001;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;actomyosin structure organization#GO:0031032;cell development#GO:0048468;cell differentiation#GO:0030154;muscle structure development#GO:0061061;actin cytoskeleton organization#GO:0030036;developmental process#GO:0032502;cellular anatomical entity morphogenesis#GO:0032989;anatomical structure formation involved in morphogenesis#GO:0048646;striated muscle cell differentiation#GO:0051146;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607 membraneless organelle#GO:0043228;myofibril#GO:0030016;sarcomere#GO:0030017;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;M band#GO:0031430;intracellular organelle#GO:0043229;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;supramolecular complex#GO:0099080;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;A band#GO:0031672;contractile muscle fiber#GO:0043292 structural protein#PC00211 HUMAN|HGNC=3689|UniProtKB=P21802 P21802 FGFR2 PTHR24416:SF130 TYROSINE-PROTEIN KINASE RECEPTOR FIBROBLAST GROWTH FACTOR RECEPTOR 2 kinase activity#GO:0016301;transferase activity#GO:0016740;signaling receptor activity#GO:0038023;fibroblast growth factor binding#GO:0017134;transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488;protein kinase activity#GO:0004672;growth factor binding#GO:0019838;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein binding#GO:0005515;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity, acting on a protein#GO:0140096;molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714 regulation of signaling#GO:0023051;animal gross anatomical part developmental process#GO:0160108;regulation of intracellular signal transduction#GO:1902531;cellular response to growth factor stimulus#GO:0071363;angiogenesis#GO:0001525;positive regulation of signaling#GO:0023056;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;response to endogenous stimulus#GO:0009719;positive regulation of cell population proliferation#GO:0008284;blood vessel morphogenesis#GO:0048514;signaling#GO:0023052;response to stimulus#GO:0050896;circulatory system development#GO:0072359;cellular response to endogenous stimulus#GO:0071495;regulation of MAPK cascade#GO:0043408;cell surface receptor signaling pathway#GO:0007166;anatomical structure formation involved in morphogenesis#GO:0048646;vasculature development#GO:0001944;multicellular organism development#GO:0007275;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular response to fibroblast growth factor stimulus#GO:0044344;cellular process#GO:0009987;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;system development#GO:0048731;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;tube morphogenesis#GO:0035239;cellular response to stimulus#GO:0051716;blood vessel development#GO:0001568;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;response to growth factor#GO:0070848;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;developmental process#GO:0032502;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;response to fibroblast growth factor#GO:0071774;positive regulation of MAPK cascade#GO:0043410;positive regulation of cellular process#GO:0048522;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;tube development#GO:0035295;positive regulation of response to stimulus#GO:0048584;multicellular organismal process#GO:0032501;fibroblast growth factor receptor signaling pathway#GO:0008543 cell periphery#GO:0071944;signaling receptor complex#GO:0043235;membrane#GO:0016020;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 FGF signaling pathway#P00021>FGFR1-4#P00636 HUMAN|HGNC=1158|UniProtKB=P30536 P30536 TSPO PTHR10057:SF5 PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR TRANSLOCATOR PROTEIN cytoplasm#GO:0005737;organelle outer membrane#GO:0031968;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;membrane#GO:0016020;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;mitochondrial outer membrane#GO:0005741;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;organelle envelope#GO:0031967;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;outer membrane#GO:0019867;intracellular organelle#GO:0043229 HUMAN|HGNC=24972|UniProtKB=Q9Y5Z7 Q9Y5Z7 HCFC2 PTHR46003:SF2 HOST CELL FACTOR HOST CELL FACTOR 2 transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;transcription coactivator activity#GO:0003713 regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;chromatin organization#GO:0006325;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;chromatin remodeling#GO:0006338 transferase complex#GO:1990234;histone methyltransferase complex#GO:0035097;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;methyltransferase complex#GO:0034708;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165 HUMAN|HGNC=22944|UniProtKB=P59044 P59044 NLRP6 PTHR45690:SF1 NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12 NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 6 signaling receptor activity#GO:0038023;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;peptide binding#GO:0042277;transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;binding#GO:0005488;molecular transducer activity#GO:0060089 regulation of response to external stimulus#GO:0032101;response to stimulus#GO:0050896;biological regulation#GO:0065007;response to stress#GO:0006950;regulation of biological process#GO:0050789;defense response#GO:0006952;acute inflammatory response#GO:0002526;regulation of response to stress#GO:0080134;regulation of defense response#GO:0031347;regulation of inflammatory response#GO:0050727;regulation of response to stimulus#GO:0048583;inflammatory response#GO:0006954 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;canonical inflammasome complex#GO:0061702;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytosol#GO:0005829 defense/immunity protein#PC00090 HUMAN|HGNC=385|UniProtKB=P52895 P52895 AKR1C2 PTHR11732:SF165 ALDO/KETO REDUCTASE ALDO-KETO REDUCTASE FAMILY 1 MEMBER C1-RELATED oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;monooxygenase activity#GO:0004497;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen#GO:0016709;alcohol dehydrogenase (NADP+) activity#GO:0008106;oxidoreductase activity#GO:0016491;organic acid binding#GO:0043177;ion binding#GO:0043167;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;binding#GO:0005488;anion binding#GO:0043168;small molecule binding#GO:0036094;carboxylic acid binding#GO:0031406;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614 oxoacid metabolic process#GO:0043436;olefinic compound metabolic process#GO:0120254;prostaglandin metabolic process#GO:0006693;regulation of biological quality#GO:0065008;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;ketone metabolic process#GO:0042180;regulation of hormone levels#GO:0010817;small molecule metabolic process#GO:0044281;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;alcohol metabolic process#GO:0006066;unsaturated fatty acid metabolic process#GO:0033559;lipid metabolic process#GO:0006629;secondary metabolic process#GO:0019748;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;hormone metabolic process#GO:0042445;icosanoid metabolic process#GO:0006690;biological regulation#GO:0065007;steroid metabolic process#GO:0008202 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 oxidoreductase#PC00176;reductase#PC00198 HUMAN|HGNC=13998|UniProtKB=Q9H4Q3 Q9H4Q3 PRDM13 PTHR16515:SF21 PR DOMAIN ZINC FINGER PROTEIN PR DOMAIN ZINC FINGER PROTEIN 13 regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264;zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=29565|UniProtKB=Q86YN1 Q86YN1 DOLPP1 PTHR11247:SF82 PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1 DOLICHYLDIPHOSPHATASE 1 hydrolase activity#GO:0016787;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817 biosynthetic process#GO:0009058;protein N-linked glycosylation#GO:0006487;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100 intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020 protein modifying enzyme#PC00260 HUMAN|HGNC=12858|UniProtKB=P43403 P43403 ZAP70 PTHR24418:SF369 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE ZAP-70 phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein tyrosine kinase activity#GO:0004713;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 non-receptor tyrosine protein kinase#PC00168 T cell activation#P00053>ZAP-70#P01308 HUMAN|HGNC=15249|UniProtKB=Q8NGI9 Q8NGI9 OR5A2 PTHR26452:SF176 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5A2 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606;sensory perception#GO:0007600;nervous system process#GO:0050877 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=8241|UniProtKB=P58173 P58173 OR2B6 PTHR26453:SF202 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2B6 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 system process#GO:0003008;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;sensory perception#GO:0007600;nervous system process#GO:0050877;response to stimulus#GO:0050896;response to chemical#GO:0042221;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;detection of chemical stimulus#GO:0009593 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=3674|UniProtKB=O76093 O76093 FGF18 PTHR11486:SF4 FIBROBLAST GROWTH FACTOR FIBROBLAST GROWTH FACTOR 18 molecular function activator activity#GO:0140677;protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;fibroblast growth factor receptor binding#GO:0005104;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;growth factor activity#GO:0008083;growth factor receptor binding#GO:0070851 response to endogenous stimulus#GO:0009719;positive regulation of cell population proliferation#GO:0008284;regulation of biological process#GO:0050789;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;cell differentiation#GO:0030154;signaling#GO:0023052;regulation of intracellular signal transduction#GO:1902531;animal gross anatomical part developmental process#GO:0160108;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;cellular response to growth factor stimulus#GO:0071363;cellular process#GO:0009987;cellular response to fibroblast growth factor stimulus#GO:0044344;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;nervous system development#GO:0007399;cell surface receptor signaling pathway#GO:0007166;regulation of MAPK cascade#GO:0043408;multicellular organism development#GO:0007275;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;response to growth factor#GO:0070848;regulation of cell communication#GO:0010646;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of cell motility#GO:2000145;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;system development#GO:0048731;positive regulation of cellular process#GO:0048522;multicellular organismal process#GO:0032501;fibroblast growth factor receptor signaling pathway#GO:0008543;positive regulation of response to stimulus#GO:0048584;regulation of locomotion#GO:0040012;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;response to fibroblast growth factor#GO:0071774;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;regulation of cell migration#GO:0030334;developmental process#GO:0032502;positive regulation of MAPK cascade#GO:0043410;cellular developmental process#GO:0048869;neurogenesis#GO:0022008 extracellular region#GO:0005576;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 growth factor#PC00112;intercellular signal molecule#PC00207 FGF signaling pathway#P00021>FGF#P00623 HUMAN|HGNC=1226|UniProtKB=O14908 O14908 GIPC1 PTHR12259:SF4 RGS-GAIP INTERACTING PROTEIN GIPC PDZ DOMAIN-CONTAINING PROTEIN GIPC1 scaffold/adaptor protein#PC00226 HUMAN|HGNC=22988|UniProtKB=Q9BWV2 Q9BWV2 SPATA9 PTHR35669:SF1 SPERMATOGENESIS-ASSOCIATED PROTEIN 9 SPERMATOGENESIS-ASSOCIATED PROTEIN 9 HUMAN|HGNC=3805|UniProtKB=Q12950 Q12950 FOXD4 PTHR11829:SF404 FORKHEAD BOX PROTEIN FORKHEAD BOX PROTEIN D4-RELATED RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;developmental process#GO:0032502;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=23346|UniProtKB=Q0VAA2 Q0VAA2 LRRC74A PTHR24114:SF50 LEUCINE RICH REPEAT FAMILY PROTEIN LEUCINE-RICH REPEAT-CONTAINING PROTEIN 74A HUMAN|HGNC=23730|UniProtKB=O60269 O60269 GPRIN2 PTHR15718:SF5 G PROTEIN-REGULATED INDUCER OF NEURITE OUTGROWTH C-TERMINAL DOMAIN-CONTAINING PROTEIN G PROTEIN-REGULATED INDUCER OF NEURITE OUTGROWTH 2 plasma membrane bounded cell projection organization#GO:0120036;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;cellular process#GO:0009987;neuron projection development#GO:0031175;neurogenesis#GO:0022008;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;developmental process#GO:0032502;neuron differentiation#GO:0030182;cell development#GO:0048468;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cellular component organization#GO:0016043;system development#GO:0048731;neuron development#GO:0048666;anatomical structure development#GO:0048856;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HUMAN|HGNC=8471|UniProtKB=Q96RD0 Q96RD0 OR8B2 PTHR48018:SF61 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 8B2-RELATED molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 cell communication#GO:0007154;nervous system process#GO:0050877;sensory perception#GO:0007600;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052;regulation of cellular process#GO:0050794;sensory perception of smell#GO:0007608;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;cellular process#GO:0009987;signal transduction#GO:0007165 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=13821|UniProtKB=Q9GZZ7 Q9GZZ7 GFRA4 PTHR10269:SF2 GDNF RECEPTOR ALPHA GDNF FAMILY RECEPTOR ALPHA-4 cytokine receptor activity#GO:0004896;transmembrane signaling receptor activity#GO:0004888;immune receptor activity#GO:0140375;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 multicellular organism development#GO:0007275;anatomical structure development#GO:0048856;multicellular organismal process#GO:0032501;system development#GO:0048731;nervous system development#GO:0007399;animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502 side of membrane#GO:0098552;external side of plasma membrane#GO:0009897;signaling receptor complex#GO:0043235;plasma membrane#GO:0005886;cell surface#GO:0009986;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=16922|UniProtKB=Q9UPQ3 Q9UPQ3 AGAP1 PTHR45819:SF1 CENTAURIN-GAMMA-1A ARF-GAP WITH GTPASE, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 1 catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;enzyme activator activity#GO:0008047;hydrolase activity, acting on acid anhydrides#GO:0016817;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;ribonucleoside triphosphate phosphatase activity#GO:0017111;molecular function regulator activity#GO:0098772;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924;enzyme regulator activity#GO:0030234;hydrolase activity#GO:0016787;molecular function activator activity#GO:0140677 G-protein modulator#PC00022;GTPase-activating protein#PC00257 HUMAN|HGNC=10917|UniProtKB=Q13183 Q13183 SLC13A2 PTHR10283:SF139 SOLUTE CARRIER FAMILY 13 MEMBER SOLUTE CARRIER FAMILY 13 MEMBER 2 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 transport#GO:0006810;cellular process#GO:0009987;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227;secondary carrier transporter#PC00258 HUMAN|HGNC=24260|UniProtKB=Q9Y3C7 Q9Y3C7 MED31 PTHR13186:SF0 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;core mediator complex#GO:0070847;RNA polymerase II transcription regulator complex#GO:0090575;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular anatomical structure#GO:0005622;mediator complex#GO:0016592;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031;general transcription factor#PC00259 HUMAN|HGNC=24858|UniProtKB=Q9GZY8 Q9GZY8 MFF PTHR16501:SF20 TRANSPORT AND GOLGI ORGANIZATION PROTEIN 11 MITOCHONDRIAL FISSION FACTOR positive regulation of developmental process#GO:0051094;intracellular protein localization#GO:0008104;regulation of anatomical structure morphogenesis#GO:0022603;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;macromolecule localization#GO:0033036;biological regulation#GO:0065007;positive regulation of cellular component organization#GO:0051130;localization#GO:0051179;positive regulation of organelle organization#GO:0010638;regulation of mitochondrion organization#GO:0010821;regulation of biological process#GO:0050789;protein localization to mitochondrion#GO:0070585;regulation of organelle organization#GO:0033043;regulation of mitochondrial fission#GO:0090140;positive regulation of mitochondrial fission#GO:0090141;regulation of developmental process#GO:0050793;regulation of cellular component organization#GO:0051128;protein localization to organelle#GO:0033365;regulation of cellular process#GO:0050794 mitochondrion#GO:0005739;peroxisome#GO:0005777;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;outer membrane#GO:0019867;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;microbody#GO:0042579;membrane#GO:0016020;cytoplasm#GO:0005737;organelle outer membrane#GO:0031968;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;mitochondrial outer membrane#GO:0005741 HUMAN|HGNC=7763|UniProtKB=Q15784 Q15784 NEUROD2 PTHR19290:SF83 BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED NEUROGENIC DIFFERENTIATION FACTOR 2 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 cellular component organization#GO:0016043;regulation of biological process#GO:0050789;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;cell projection organization#GO:0030030;cell development#GO:0048468;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;neuron development#GO:0048666;neuron projection development#GO:0031175;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;nervous system development#GO:0007399;positive regulation of transcription by RNA polymerase II#GO:0045944;neuron differentiation#GO:0030182;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;animal organ development#GO:0048513;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biosynthetic process#GO:0009891;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;axon development#GO:0061564;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of cellular process#GO:0048522;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;positive regulation of DNA-templated transcription#GO:0045893;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;plasma membrane bounded cell projection organization#GO:0120036;sensory organ development#GO:0007423;developmental process#GO:0032502;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=18623|UniProtKB=Q96MW5 Q96MW5 COG8 PTHR21311:SF0 CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 8 CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 8 transport#GO:0006810;Golgi vesicle transport#GO:0048193;establishment of localization#GO:0051234;localization#GO:0051179;retrograde transport, vesicle recycling within Golgi#GO:0000301;cellular process#GO:0009987;intra-Golgi vesicle-mediated transport#GO:0006891;vesicle-mediated transport#GO:0016192 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;COG complex#GO:0017119;membrane-bounded organelle#GO:0043227;vesicle tethering complex#GO:0099023;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=17676|UniProtKB=Q9UJ41 Q9UJ41 RABGEF1 PTHR23101:SF122 RAB GDP/GTP EXCHANGE FACTOR RAB5 GDP_GTP EXCHANGE FACTOR nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;small GTPase binding#GO:0031267;protein binding#GO:0005515;guanyl-nucleotide exchange factor activity#GO:0005085;binding#GO:0005488;enzyme binding#GO:0019899 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cytosol#GO:0005829;intracellular vesicle#GO:0097708;vesicle#GO:0031982;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endocytic vesicle#GO:0030139;intracellular organelle#GO:0043229 protein-binding activity modulator#PC00095;guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=3527|UniProtKB=Q15910 Q15910 EZH2 PTHR45747:SF3 HISTONE-LYSINE N-METHYLTRANSFERASE E(Z) HISTONE-LYSINE N-METHYLTRANSFERASE EZH2 histone modifying activity#GO:0140993;histone H3 methyltransferase activity#GO:0140938;lysine N-methyltransferase activity#GO:0016278;N-methyltransferase activity#GO:0008170;protein-lysine N-methyltransferase activity#GO:0016279;chromatin binding#GO:0003682;histone methyltransferase activity#GO:0042054;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;binding#GO:0005488;catalytic activity, acting on a protein#GO:0140096;protein methyltransferase activity#GO:0008276;transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;catalytic activity#GO:0003824 negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of gene expression, epigenetic#GO:0045814;cellular component organization or biogenesis#GO:0071840;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cellular component assembly#GO:0022607;heterochromatin organization#GO:0070828;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;negative regulation of cellular process#GO:0048523;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;epigenetic regulation of gene expression#GO:0040029;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;chromatin organization#GO:0006325;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;heterochromatin formation#GO:0031507;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255 organelle lumen#GO:0043233;organelle#GO:0043226;nucleoplasm#GO:0005654;methyltransferase complex#GO:0034708;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;PcG protein complex#GO:0031519;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;transferase complex#GO:1990234;histone methyltransferase complex#GO:0035097;nuclear protein-containing complex#GO:0140513 histone modifying enzyme#PC00261 HUMAN|HGNC=14376|UniProtKB=Q9BZG2 Q9BZG2 ACP4 PTHR11567:SF145 ACID PHOSPHATASE-RELATED TESTICULAR ACID PHOSPHATASE catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;receptor tyrosine kinase binding#GO:0030971;phosphatase activity#GO:0016791;hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721;protein tyrosine kinase binding#GO:1990782;signaling receptor binding#GO:0005102;phosphoric ester hydrolase activity#GO:0042578;protein tyrosine phosphatase activity#GO:0004725;protein binding#GO:0005515;binding#GO:0005488;kinase binding#GO:0019900;enzyme binding#GO:0019899;protein kinase binding#GO:0019901 regulation of neuronal synaptic plasticity#GO:0048168;regulation of response to stimulus#GO:0048583;regulation of synaptic plasticity#GO:0048167;negative regulation of cellular process#GO:0048523;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;negative regulation of response to stimulus#GO:0048585;regulation of trans-synaptic signaling#GO:0099177;regulation of biological quality#GO:0065008;negative regulation of cell communication#GO:0010648;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of ERBB signaling pathway#GO:1901184;negative regulation of biological process#GO:0048519 phosphatase#PC00181 HUMAN|HGNC=11834|UniProtKB=P29401 P29401 TKT PTHR43195:SF3 TRANSKETOLASE TRANSKETOLASE ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;binding#GO:0005488;cation binding#GO:0043169;transketolase activity#GO:0004802;transketolase or transaldolase activity#GO:0016744;transferase activity#GO:0016740;catalytic activity#GO:0003824;heterocyclic compound binding#GO:1901363 nucleotide metabolic process#GO:0009117;NADPH regeneration#GO:0006740;glyceraldehyde-3-phosphate metabolic process#GO:0019682;pyridine-containing compound metabolic process#GO:0072524;pentose-phosphate shunt#GO:0006098;pentose-phosphate shunt, non-oxidative branch#GO:0009052;nucleoside phosphate metabolic process#GO:0006753;glucose 6-phosphate metabolic process#GO:0051156;small molecule metabolic process#GO:0044281;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;nucleobase-containing small molecule metabolic process#GO:0055086;generation of precursor metabolites and energy#GO:0006091;metabolic process#GO:0008152;nucleobase-containing compound metabolic process#GO:0006139;aldehyde metabolic process#GO:0006081;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;nicotinamide nucleotide metabolic process#GO:0046496;NADP+ metabolic process#GO:0006739;organophosphate metabolic process#GO:0019637 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;transketolase#PC00221 Pentose phosphate pathway#P02762>Transketolase#P03082 HUMAN|HGNC=29889|UniProtKB=Q7RTR2 Q7RTR2 NLRC3 PTHR24106:SF284 NACHT, LRR AND CARD DOMAINS-CONTAINING NLR FAMILY CARD DOMAIN-CONTAINING PROTEIN 3 molecular function inhibitor activity#GO:0140678;molecular function regulator activity#GO:0098772 scaffold/adaptor protein#PC00226 HUMAN|HGNC=9212|UniProtKB=P14859 P14859 POU2F1 PTHR11636:SF47 POU DOMAIN POU DOMAIN, CLASS 2, TRANSCRIPTION FACTOR 1 cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular anatomical structure#GO:0005622 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 Gonadotropin-releasing hormone receptor pathway#P06664>OCT-1#P06720 HUMAN|HGNC=6953|UniProtKB=P15529 P15529 CD46 PTHR19325:SF521 COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING MEMBRANE COFACTOR PROTEIN regulation of response to stimulus#GO:0048583;immune effector process#GO:0002252;immune response#GO:0006955;negative regulation of response to stimulus#GO:0048585;adaptive immune response#GO:0002250;biological regulation#GO:0065007;negative regulation of immune system process#GO:0002683;immune system process#GO:0002376;regulation of lymphocyte mediated immunity#GO:0002706;regulation of immune response#GO:0050776;negative regulation of immune response#GO:0050777;T cell mediated immunity#GO:0002456;lymphocyte mediated immunity#GO:0002449;regulation of immune effector process#GO:0002697;leukocyte mediated immunity#GO:0002443;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;negative regulation of biological process#GO:0048519;regulation of leukocyte mediated immunity#GO:0002703;regulation of biological process#GO:0050789;regulation of immune system process#GO:0002682;response to stimulus#GO:0050896 membrane#GO:0016020;cell periphery#GO:0071944;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 defense/immunity protein#PC00090;complement component#PC00078 HUMAN|HGNC=20625|UniProtKB=M0R2J8 M0R2J8 DCDC1 PTHR46302:SF3 DOUBLECORTIN DOMAIN-CONTAINING PROTEIN 1 DOUBLECORTIN DOMAIN-CONTAINING PROTEIN 1 protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;microtubule binding#GO:0008017;binding#GO:0005488 regulation of cytokinesis#GO:0032465;regulation of cell division#GO:0051302;regulation of mitotic cytokinesis#GO:1902412;regulation of biological process#GO:0050789;biological regulation#GO:0065007;regulation of cell cycle process#GO:0010564;regulation of cell cycle#GO:0051726;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;midbody#GO:0030496 HUMAN|HGNC=25893|UniProtKB=Q96K80 Q96K80 ZC3H10 PTHR12675:SF6 MUSCLEBLIND-LIKE PROTEIN ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 10 nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 biological regulation#GO:0065007;regulation of RNA splicing#GO:0043484;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 RNA splicing factor#PC00148;RNA processing factor#PC00147 HUMAN|HGNC=28852|UniProtKB=Q8N0S2 Q8N0S2 SYCE1 PTHR21731:SF0 SYNAPTONEMAL COMPLEX CENTRAL ELEMENT PROTEIN 1-LIKE SYNAPTONEMAL COMPLEX CENTRAL ELEMENT PROTEIN 1 chromosome#GO:0005694;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;synaptonemal structure#GO:0099086;condensed chromosome#GO:0000793;condensed nuclear chromosome#GO:0000794;synaptonemal complex#GO:0000795;membraneless organelle#GO:0043228 HUMAN|HGNC=954|UniProtKB=Q9NY43 Q9NY43 BARHL2 PTHR24330:SF4 HOMEOBOX PROTEIN BARH-LIKE BARH-LIKE 2 HOMEOBOX PROTEIN transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=1594|UniProtKB=P51946 P51946 CCNH PTHR10026:SF8 CYCLIN CYCLIN-H protein kinase regulator activity#GO:0019887;cyclin-dependent protein kinase regulator activity#GO:0019914;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538 gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;transcription initiation at RNA polymerase II promoter#GO:0006367;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;transcription by RNA polymerase II#GO:0006366;DNA-templated transcription initiation#GO:0006352;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187 protein-containing complex#GO:0032991;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;membrane-enclosed lumen#GO:0031974;RNA polymerase II transcription regulator complex#GO:0090575;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;transcription regulator complex#GO:0005667;protein kinase complex#GO:1902911;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;RNA polymerase II, holoenzyme#GO:0016591;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;transcription factor TFIIH holo complex#GO:0005675;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 kinase activator#PC00138;kinase modulator#PC00140 HUMAN|HGNC=28853|UniProtKB=Q8TAC2 Q8TAC2 JOSD2 PTHR13291:SF2 JOSEPHIN 1, 2 JOSEPHIN-2 hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;cysteine-type deubiquitinase activity#GO:0004843 cysteine protease#PC00081;protein modifying enzyme#PC00260 HUMAN|HGNC=26300|UniProtKB=Q17RF5 Q17RF5 ODAPH PTHR40376:SF1 ODONTOGENESIS ASSOCIATED PHOSPHOPROTEIN ODONTOGENESIS ASSOCIATED PHOSPHOPROTEIN regulation of multicellular organismal development#GO:2000026;regulation of biological process#GO:0050789;positive regulation of biological process#GO:0048518;positive regulation of developmental process#GO:0051094;regulation of multicellular organismal process#GO:0051239;regulation of developmental process#GO:0050793;biological regulation#GO:0065007 HUMAN|HGNC=2076|UniProtKB=O75503 O75503 CLN5 PTHR15380:SF2 CEROID-LIPOFUSCINOSIS, NEURONAL 5 BIS(MONOACYLGLYCERO)PHOSPHATE SYNTHASE CLN5 catalytic activity#GO:0003824;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787 cellular component organization or biogenesis#GO:0071840;vacuole organization#GO:0007033;cellular component organization#GO:0016043;organelle organization#GO:0006996;lysosome organization#GO:0007040;cellular process#GO:0009987;lytic vacuole organization#GO:0080171 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;lytic vacuole membrane#GO:0098852;lysosome#GO:0005764;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;vacuole#GO:0005773;cytoplasm#GO:0005737;membrane#GO:0016020;lysosomal membrane#GO:0005765;lytic vacuole#GO:0000323;vacuolar membrane#GO:0005774;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588 HUMAN|HGNC=18384|UniProtKB=Q96QR1 Q96QR1 SCGB3A1 PTHR34829:SF1 SECRETOGLOBIN FAMILY 3A MEMBER 2 SECRETOGLOBIN FAMILY 3A MEMBER 1 biological regulation#GO:0065007;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;positive regulation of cellular process#GO:0048522;positive regulation of cellular component organization#GO:0051130;positive regulation of biological process#GO:0048518 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=5895|UniProtKB=P01709 P01709 IGLV2-8 PTHR23267:SF437 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN LAMBDA VARIABLE 2-8 immune system process#GO:0002376;immune response#GO:0006955;response to stimulus#GO:0050896 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=10750|UniProtKB=Q9UH03 Q9UH03 SEPTIN3 PTHR18884:SF62 SEPTIN NEURONAL-SPECIFIC SEPTIN-3 hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817 cellular process#GO:0009987;cell cycle process#GO:0022402;cell division#GO:0051301;macromolecule localization#GO:0033036;cell cycle#GO:0007049;cytokinesis#GO:0000910;intracellular protein localization#GO:0008104;cytoskeleton-dependent cytokinesis#GO:0061640;localization#GO:0051179 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cell division site#GO:0032153;microtubule cytoskeleton#GO:0015630;cell periphery#GO:0071944;cell cortex#GO:0005938;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 cytoskeletal protein#PC00085 HUMAN|HGNC=12156|UniProtKB=P01850 P01850 TRBC1 PTHR23411:SF34 TAPASIN T CELL RECEPTOR BETA CONSTANT 1 membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;signaling receptor complex#GO:0043235 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=19592|UniProtKB=Q8NG77 Q8NG77 OR2T12 PTHR26453:SF643 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2T12 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 detection of chemical stimulus#GO:0009593;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;response to stimulus#GO:0050896;response to chemical#GO:0042221;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;sensory perception#GO:0007600;nervous system process#GO:0050877;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;system process#GO:0003008 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=33857|UniProtKB=Q5FWF7 Q5FWF7 FBXO48 PTHR12874:SF9 F-BOX ONLY PROTEIN 48-RELATED F-BOX ONLY PROTEIN 48 ubiquitin-like ligase-substrate adaptor activity#GO:1990756;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;enzyme-substrate adaptor activity#GO:0140767 ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;macromolecule catabolic process#GO:0009057;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238 transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;ubiquitin ligase complex#GO:0000151;cytoplasm#GO:0005737;SCF ubiquitin ligase complex#GO:0019005;cullin-RING ubiquitin ligase complex#GO:0031461;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 HUMAN|HGNC=4432|UniProtKB=P17174 P17174 GOT1 PTHR11879:SF3 ASPARTATE AMINOTRANSFERASE ASPARTATE AMINOTRANSFERASE, CYTOPLASMIC primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;aspartate family amino acid biosynthetic process#GO:0009067;carboxylic acid biosynthetic process#GO:0046394;cellular process#GO:0009987;proteinogenic amino acid metabolic process#GO:0170039;small molecule metabolic process#GO:0044281;amino acid metabolic process#GO:0006520;biosynthetic process#GO:0009058;amino acid biosynthetic process#GO:0008652;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;small molecule biosynthetic process#GO:0044283;proteinogenic amino acid biosynthetic process#GO:0170038 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 metabolite interconversion enzyme#PC00262;transferase#PC00220;transaminase#PC00216 Asparagine and aspartate biosynthesis#P02730>Aspartate aminotransferase#P02854 HUMAN|HGNC=19744|UniProtKB=O43295 O43295 SRGAP3 PTHR14166:SF8 SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 3 enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047 regulation of synapse assembly#GO:0051963;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;negative regulation of cell motility#GO:2000146;negative regulation of locomotion#GO:0040013;nervous system development#GO:0007399;regulation of locomotion#GO:0040012;multicellular organism development#GO:0007275;negative regulation of cell migration#GO:0030336;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;regulation of cell migration#GO:0030334;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of cellular component biogenesis#GO:0044087;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cell motility#GO:2000145;regulation of synapse structure or activity#GO:0050803;anatomical structure development#GO:0048856;system development#GO:0048731;regulation of biological quality#GO:0065008;animal gross anatomical part developmental process#GO:0160108;regulation of cell junction assembly#GO:1901888;regulation of synapse organization#GO:0050807 GTPase-activating protein#PC00257;G-protein modulator#PC00022 PDGF signaling pathway#P00047>Rho#P01174 HUMAN|HGNC=17470|UniProtKB=Q6UW88 Q6UW88 EPGN PTHR10740:SF10 TRANSFORMING GROWTH FACTOR ALPHA EPIGEN protein binding#GO:0005515;molecular function activator activity#GO:0140677;binding#GO:0005488;signaling receptor binding#GO:0005102;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;growth factor activity#GO:0008083;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;growth factor receptor binding#GO:0070851 cell surface receptor signaling pathway#GO:0007166;positive regulation of mitotic nuclear division#GO:0045840;regulation of mitotic nuclear division#GO:0007088;cellular process#GO:0009987;ERBB signaling pathway#GO:0038127;regulation of mitotic cell cycle#GO:0007346;signal transduction#GO:0007165;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;epidermal growth factor receptor signaling pathway#GO:0007173;regulation of nuclear division#GO:0051783;positive regulation of cell cycle#GO:0045787;biological regulation#GO:0065007;regulation of cell cycle process#GO:0010564;positive regulation of cellular component organization#GO:0051130;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of organelle organization#GO:0010638;regulation of cell population proliferation#GO:0042127;cell communication#GO:0007154;positive regulation of cell population proliferation#GO:0008284;regulation of organelle organization#GO:0033043;cellular response to stimulus#GO:0051716;positive regulation of cell cycle process#GO:0090068;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;regulation of cell cycle#GO:0051726;signaling#GO:0023052 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 growth factor#PC00112 HUMAN|HGNC=15590|UniProtKB=O94989 O94989 ARHGEF15 PTHR12845:SF7 GUANINE NUCLEOTIDE EXCHANGE FACTOR RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 15 molecular function regulator activity#GO:0098772;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;guanyl-nucleotide exchange factor activity#GO:0005085 regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of actin cytoskeleton organization#GO:0032956;regulation of actin filament-based process#GO:0032970 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HUMAN|HGNC=7737|UniProtKB=P12036 P12036 NEFH PTHR23214:SF1 NEUROFILAMENT TRIPLET H PROTEIN NEUROFILAMENT HEAVY POLYPEPTIDE structural constituent of synapse#GO:0098918;structural molecule activity#GO:0005198;structural constituent of cytoskeleton#GO:0005200 intermediate filament cytoskeleton organization#GO:0045104;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell development#GO:0048468;cellular component organization#GO:0016043;anatomical structure development#GO:0048856;neuron development#GO:0048666;supramolecular fiber organization#GO:0097435;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;intermediate filament-based process#GO:0045103;intermediate filament organization#GO:0045109;generation of neurons#GO:0048699;multicellular organismal process#GO:0032501;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;nervous system development#GO:0007399;cytoskeleton organization#GO:0007010;axon development#GO:0061564;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;neuron projection development#GO:0031175;cellular process#GO:0009987;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;neurogenesis#GO:0022008;intermediate filament bundle assembly#GO:0045110;developmental process#GO:0032502;neuron differentiation#GO:0030182 plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;axon#GO:0030424;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;neuron projection#GO:0043005;intermediate filament#GO:0005882;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cytoskeleton#GO:0005856 HUMAN|HGNC=17288|UniProtKB=Q6Q788 Q6Q788 APOA5 PTHR18976:SF13 APOLIPOPROTEIN APOLIPOPROTEIN A-V binding#GO:0005488;lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104;lipid transfer activity#GO:0120013;molecular function activator activity#GO:0140677;lipid binding#GO:0008289;enzyme regulator activity#GO:0030234;transporter activity#GO:0005215;sterol transfer activity#GO:0120015;phospholipid binding#GO:0005543;enzyme activator activity#GO:0008047;cholesterol transfer activity#GO:0120020;molecular function regulator activity#GO:0098772 homeostatic process#GO:0042592;secondary alcohol metabolic process#GO:1902652;organophosphate ester transport#GO:0015748;small molecule metabolic process#GO:0044281;primary metabolic process#GO:0044238;lipid homeostasis#GO:0055088;organic hydroxy compound transport#GO:0015850;localization#GO:0051179;lipid localization#GO:0010876;phospholipid transport#GO:0015914;steroid metabolic process#GO:0008202;lipid transport#GO:0006869;cholesterol efflux#GO:0033344;cellular process#GO:0009987;macromolecule localization#GO:0033036;cholesterol transport#GO:0030301;sterol transport#GO:0015918;establishment of localization#GO:0051234;sterol metabolic process#GO:0016125;lipid metabolic process#GO:0006629;cholesterol metabolic process#GO:0008203;transport#GO:0006810;chemical homeostasis#GO:0048878;metabolic process#GO:0008152;alcohol metabolic process#GO:0006066 extracellular region#GO:0005576;extracellular protein-containing complex#GO:0140392;protein-lipid complex#GO:0032994;lipoprotein particle#GO:1990777;plasma lipoprotein particle#GO:0034358;membrane-bounded organelle#GO:0043227;high-density lipoprotein particle#GO:0034364;very-low-density lipoprotein particle#GO:0034361;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226 apolipoprotein#PC00052;transfer/carrier protein#PC00219 HUMAN|HGNC=19861|UniProtKB=Q6ZMZ3 Q6ZMZ3 SYNE3 PTHR47535:SF2 MUSCLE-SPECIFIC PROTEIN 300 KDA, ISOFORM G NESPRIN-3 protein-containing complex binding#GO:0044877;protein binding#GO:0005515;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;actin filament binding#GO:0051015;binding#GO:0005488 cellular process#GO:0009987;establishment of localization in cell#GO:0051649;nuclear migration#GO:0007097;establishment of organelle localization#GO:0051656;organelle localization#GO:0051640;intracellular transport#GO:0046907;transport#GO:0006810;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179 nuclear protein-containing complex#GO:0140513;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;nuclear membrane#GO:0031965;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;organelle outer membrane#GO:0031968;cytoplasm#GO:0005737;nuclear envelope#GO:0005635;membrane#GO:0016020;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;outer membrane#GO:0019867;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;organelle envelope#GO:0031967 HUMAN|HGNC=30313|UniProtKB=Q5T4S7 Q5T4S7 UBR4 PTHR21725:SF1 E3 UBIQUITIN-PROTEIN LIGASE UBR4 E3 UBIQUITIN-PROTEIN LIGASE UBR4 catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659 ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;protein quality control for misfolded or incompletely synthesized proteins#GO:0006515;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=26021|UniProtKB=Q9NX58 Q9NX58 LYAR PTHR13100:SF10 CELL GROWTH-REGULATING NUCLEOLAR PROTEIN LYAR CELL GROWTH-REGULATING NUCLEOLAR PROTEIN binding#GO:0005488;nucleic acid binding#GO:0003676;DNA binding#GO:0003677 negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;regulation of RNA biosynthetic process#GO:2001141;biosynthetic process#GO:0009058;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;macromolecule biosynthetic process#GO:0009059;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;rRNA metabolic process#GO:0016072;negative regulation of cellular process#GO:0048523;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of RNA metabolic process#GO:0051252;rRNA processing#GO:0006364;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of DNA-templated transcription#GO:0006355;RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component organization or biogenesis#GO:0071840;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;ribonucleoprotein complex biogenesis#GO:0022613;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;RNA metabolic process#GO:0016070;negative regulation of DNA-templated transcription#GO:0045892;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254 intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730 RNA processing factor#PC00147 HUMAN|HGNC=20837|UniProtKB=Q6QHF9 Q6QHF9 PAOX PTHR10742:SF429 FLAVIN MONOAMINE OXIDASE PEROXISOMAL N(1)-ACETYL-SPERMINE_SPERMIDINE OXIDASE catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 metabolic process#GO:0008152;polyamine catabolic process#GO:0006598;amine catabolic process#GO:0009310;amine metabolic process#GO:0009308;polyamine metabolic process#GO:0006595;cellular process#GO:0009987;catabolic process#GO:0009056;biogenic amine metabolic process#GO:0006576 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 oxidase#PC00175 HUMAN|HGNC=5105|UniProtKB=Q00056 Q00056 HOXA4 PTHR45771:SF2 HOMEOTIC PROTEIN DEFORMED HOMEOBOX PROTEIN HOX-A4 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;positive regulation of DNA-templated transcription#GO:0045893;multicellular organismal process#GO:0032501;regionalization#GO:0003002;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;skeletal system morphogenesis#GO:0048705;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;embryonic organ development#GO:0048568;embryo development ending in birth or egg hatching#GO:0009792;pattern specification process#GO:0007389;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;animal organ morphogenesis#GO:0009887;regulation of macromolecule metabolic process#GO:0060255;animal organ development#GO:0048513;multicellular organism development#GO:0007275;embryonic morphogenesis#GO:0048598;anterior/posterior pattern specification#GO:0009952;positive regulation of transcription by RNA polymerase II#GO:0045944;embryo development#GO:0009790;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;skeletal system development#GO:0001501;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;chordate embryonic development#GO:0043009;animal gross anatomical part developmental process#GO:0160108;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 HUMAN|HGNC=27287|UniProtKB=Q8IUY3 Q8IUY3 GRAMD2A PTHR46973:SF1 GRAM DOMAIN-CONTAINING PROTEIN 2A GRAM DOMAIN-CONTAINING PROTEIN 2A lipid binding#GO:0008289;phosphatidylinositol bisphosphate binding#GO:1902936;anion binding#GO:0043168;binding#GO:0005488;small molecule binding#GO:0036094;phosphatidylinositol-4,5-bisphosphate binding#GO:0005546;ion binding#GO:0043167;phosphatidylinositol phosphate binding#GO:1901981;phospholipid binding#GO:0005543 regulation of biological process#GO:0050789;regulation of monoatomic ion transport#GO:0043269;regulation of metal ion transport#GO:0010959;regulation of calcium ion transport#GO:0051924;regulation of transport#GO:0051049;biological regulation#GO:0065007;regulation of localization#GO:0032879 cytoplasm#GO:0005737;endomembrane system#GO:0012505;membrane#GO:0016020;organelle membrane#GO:0031090;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle membrane contact site#GO:0044232;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229 HUMAN|HGNC=6808|UniProtKB=P43366 P43366 MAGEB1 PTHR11736:SF168 MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN MELANOMA-ASSOCIATED ANTIGEN B1 negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;negative regulation of metabolic process#GO:0009892;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=10059|UniProtKB=O00635 O00635 TRIM38 PTHR24103:SF47 E3 UBIQUITIN-PROTEIN LIGASE TRIM E3 UBIQUITIN-PROTEIN LIGASE TRIM38 ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824 positive regulation of signal transduction#GO:0009967;response to external biotic stimulus#GO:0043207;regulation of cell communication#GO:0010646;regulation of macromolecule metabolic process#GO:0060255;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;immune response#GO:0006955;positive regulation of cellular process#GO:0048522;regulation of canonical NF-kappaB signal transduction#GO:0043122;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;response to other organism#GO:0051707;positive regulation of response to stimulus#GO:0048584;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;response to external stimulus#GO:0009605;defense response#GO:0006952;regulation of gene expression#GO:0010468;innate immune response#GO:0045087;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;regulation of signaling#GO:0023051;immune system process#GO:0002376;regulation of intracellular signal transduction#GO:1902531;positive regulation of signaling#GO:0023056;positive regulation of biological process#GO:0048518;defense response to symbiont#GO:0140546;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;defense response to other organism#GO:0098542;positive regulation of canonical NF-kappaB signal transduction#GO:0043123 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=5361|UniProtKB=Q02363 Q02363 ID2 PTHR11723:SF5 DNA-BINDING PROTEIN INHIBITOR DNA-BINDING PROTEIN INHIBITOR ID-2 transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714;transcription regulator activity#GO:0140110 nervous system development#GO:0007399;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;multicellular organism development#GO:0007275;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;neuron differentiation#GO:0030182;negative regulation of metabolic process#GO:0009892;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218 Gonadotropin-releasing hormone receptor pathway#P06664>Id2#P06804 HUMAN|HGNC=30617|UniProtKB=Q8TE02 Q8TE02 ELP5 PTHR15641:SF1 ELONGATOR COMPLEX PROTEIN 5 ELONGATOR COMPLEX PROTEIN 5 binding#GO:0005488;nucleic acid binding#GO:0003676;tRNA binding#GO:0000049;RNA binding#GO:0003723 tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187;tRNA modification#GO:0006400;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;elongator holoenzyme complex#GO:0033588;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;catalytic complex#GO:1902494 HUMAN|HGNC=29547|UniProtKB=Q8NEM2 Q8NEM2 SHCBP1 PTHR14695:SF8 SHC SH2-DOMAIN BINDING PROTEIN 1-RELATED SHC SH2 DOMAIN-BINDING PROTEIN 1 sexual reproduction#GO:0019953;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;multicellular organismal reproductive process#GO:0048609;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;organelle fission#GO:0048285;cell division#GO:0051301;cellular response to stimulus#GO:0051716;cell cycle#GO:0007049;developmental process involved in reproduction#GO:0003006;reproductive process#GO:0022414;response to growth factor#GO:0070848;regulation of cellular process#GO:0050794;spermatogenesis#GO:0007283;developmental process#GO:0032502;response to fibroblast growth factor#GO:0071774;meiotic nuclear division#GO:0140013;biological regulation#GO:0065007;fibroblast growth factor receptor signaling pathway#GO:0008543;male gamete generation#GO:0048232;nuclear division#GO:0000280;cytokinesis#GO:0000910;cellular response to growth factor stimulus#GO:0071363;cytoskeleton-dependent cytokinesis#GO:0061640;regulation of biological process#GO:0050789;cell cycle process#GO:0022402;response to endogenous stimulus#GO:0009719;meiotic cell cycle process#GO:1903046;cellular component organization#GO:0016043;signaling#GO:0023052;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;gamete generation#GO:0007276;cell surface receptor signaling pathway#GO:0007166;meiotic cell cycle#GO:0051321;cellular component organization or biogenesis#GO:0071840;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to fibroblast growth factor stimulus#GO:0044344;organelle organization#GO:0006996;male meiotic nuclear division#GO:0007140 HUMAN|HGNC=14063|UniProtKB=P56524 P56524 HDAC4 PTHR10625:SF33 HISTONE DEACETYLASE HDAC1-RELATED HISTONE DEACETYLASE 4 histone modifying activity#GO:0140993;deacetylase activity#GO:0019213;catalytic activity, acting on a protein#GO:0140096;deacylase activity#GO:0160215;histone deacetylase activity#GO:0004407;catalytic activity#GO:0003824 regulation of biological process#GO:0050789;cellular process#GO:0009987;epigenetic regulation of gene expression#GO:0040029;cellular component organization#GO:0016043;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;chromatin organization#GO:0006325;biological regulation#GO:0065007;chromatin remodeling#GO:0006338;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889 nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;histone deacetylase complex#GO:0000118;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226 HUMAN|HGNC=95|UniProtKB=O00400 O00400 SLC33A1 PTHR12778:SF9 SOLUTE CARRIER FAMILY 33 ACETYL-COA TRANSPORTER -RELATED ACETYL-COENZYME A TRANSPORTER 1 nucleobase-containing compound transmembrane transporter activity#GO:0015932;organophosphate ester transmembrane transporter activity#GO:0015605;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;cellular process#GO:0009987;nitrogen compound transport#GO:0071705;nucleobase-containing compound transport#GO:0015931;organophosphate ester transport#GO:0015748 membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;membrane#GO:0016020 transporter#PC00227;secondary carrier transporter#PC00258 HUMAN|HGNC=9437|UniProtKB=P19525 P19525 EIF2AK2 PTHR11042:SF163 EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED INTERFERON-INDUCED, DOUBLE-STRANDED RNA-ACTIVATED PROTEIN KINASE catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of translation#GO:0006417;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;negative regulation of translation#GO:0017148;regulation of translational initiation#GO:0006446;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;negative regulation of protein metabolic process#GO:0051248;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Apoptosis signaling pathway#P00006>PKR#P00293 HUMAN|HGNC=7526|UniProtKB=P22033 P22033 MMUT PTHR48101:SF4 METHYLMALONYL-COA MUTASE, MITOCHONDRIAL-RELATED METHYLMALONYL-COA MUTASE, MITOCHONDRIAL isomerase activity#GO:0016853;tetrapyrrole binding#GO:0046906;heterocyclic compound binding#GO:1901363;small molecule binding#GO:0036094;catalytic activity#GO:0003824;binding#GO:0005488;intramolecular transferase activity#GO:0016866 acyl-CoA metabolic process#GO:0006637;nucleobase-containing small molecule metabolic process#GO:0055086;purine-containing compound catabolic process#GO:0072523;sulfur compound catabolic process#GO:0044273;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;nucleobase-containing compound metabolic process#GO:0006139;lipid catabolic process#GO:0016042;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;nucleobase-containing compound catabolic process#GO:0034655;sulfur compound metabolic process#GO:0006790;organophosphate catabolic process#GO:0046434;nucleoside phosphate metabolic process#GO:0006753;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;nucleoside phosphate catabolic process#GO:1901292;purine-containing compound metabolic process#GO:0072521;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 metabolite interconversion enzyme#PC00262;isomerase#PC00135;mutase#PC00160 Methylmalonyl pathway#P02755>Methylmalonyl-CoA mutase#P03034;Succinate to proprionate conversion#P02777>Methylmalonyl-CoA mutase#P03161 HUMAN|HGNC=37219|UniProtKB=B4DJY2 B4DJY2 TMEM233 PTHR14948:SF19 NG5 TRANSMEMBRANE PROTEIN 233 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HUMAN|HGNC=6915|UniProtKB=P02144 P02144 MB PTHR47132:SF1 MYOGLOBIN MYOGLOBIN oxidoreductase activity#GO:0016491;molecular carrier activity#GO:0140104;catalytic activity#GO:0003824 response to stress#GO:0006950;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;response to chemical#GO:0042221;cellular response to toxic substance#GO:0097237;detoxification#GO:0098754;reactive oxygen species metabolic process#GO:0072593;metabolic process#GO:0008152;superoxide metabolic process#GO:0006801;response to oxidative stress#GO:0006979;cellular response to chemical stress#GO:0062197;response to reactive oxygen species#GO:0000302;muscle system process#GO:0003012;response to stimulus#GO:0050896;skeletal muscle contraction#GO:0003009;cellular response to chemical stimulus#GO:0070887;nervous system process#GO:0050877;cellular detoxification#GO:1990748;cellular response to stress#GO:0033554;response to oxygen-containing compound#GO:1901700;cellular oxidant detoxification#GO:0098869;cellular response to oxidative stress#GO:0034599;multicellular organismal process#GO:0032501;transport#GO:0006810;muscle contraction#GO:0006936;establishment of localization#GO:0051234;system process#GO:0003008;cellular response to stimulus#GO:0051716;response to toxic substance#GO:0009636;striated muscle contraction#GO:0006941;neuromuscular process#GO:0050905;localization#GO:0051179 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;sarcoplasm#GO:0016528 transfer/carrier protein#PC00219;globin#PC00107 HUMAN|HGNC=320|UniProtKB=Q15109 Q15109 AGER PTHR11973:SF20 CELL SURFACE GLYCOPROTEIN MUC18-RELATED ADVANCED GLYCATION END PRODUCT-SPECIFIC RECEPTOR regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;modulation of chemical synaptic transmission#GO:0050804;leukocyte activation#GO:0045321;anatomical structure development#GO:0048856;system development#GO:0048731;cell activation#GO:0001775;inflammatory response#GO:0006954;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;cellular developmental process#GO:0048869;macrophage activation#GO:0042116;neurogenesis#GO:0022008;defense response#GO:0006952;regulation of synaptic plasticity#GO:0048167;developmental process#GO:0032502;cell differentiation#GO:0030154;cell projection organization#GO:0030030;response to stimulus#GO:0050896;cell development#GO:0048468;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of biological quality#GO:0065008;neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;immune system process#GO:0002376;regulation of signaling#GO:0023051;generation of neurons#GO:0048699;regulation of trans-synaptic signaling#GO:0099177;myeloid leukocyte activation#GO:0002274;nervous system development#GO:0007399;microglial cell activation#GO:0001774;response to stress#GO:0006950;neuron projection development#GO:0031175;cellular process#GO:0009987;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;neuron differentiation#GO:0030182 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;cell periphery#GO:0071944;membrane#GO:0016020 immunoglobulin superfamily cell adhesion molecule#PC00125;cell adhesion molecule#PC00069 HUMAN|HGNC=28745|UniProtKB=Q86UD7 Q86UD7 TBC1D26 PTHR22957:SF598 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN TBC1 DOMAIN FAMILY MEMBER 26 enzyme activator activity#GO:0008047;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096 G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HUMAN|HGNC=3586|UniProtKB=Q9HB96 Q9HB96 FANCE PTHR32094:SF5 FANCONI ANEMIA GROUP E PROTEIN FANCONI ANEMIA GROUP E PROTEIN membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;Fanconi anaemia nuclear complex#GO:0043240;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 HUMAN|HGNC=13047|UniProtKB=O75437 O75437 ZNF254 PTHR24377:SF912 IP01015P-RELATED ZINC FINGER PROTEIN 254-RELATED transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=29173|UniProtKB=Q674X7 Q674X7 KAZN PTHR12776:SF1 KAZRIN-RELATED KAZRIN HUMAN|HGNC=8795|UniProtKB=O76083 O76083 PDE9A PTHR11347:SF236 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE HIGH AFFINITY CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 9A hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;cyclic-nucleotide phosphodiesterase activity#GO:0004112;hydrolase activity#GO:0016787;phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578 negative regulation of intracellular signal transduction#GO:1902532;nucleotide metabolic process#GO:0009117;negative regulation of cell communication#GO:0010648;ribonucleotide metabolic process#GO:0009259;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;small molecule metabolic process#GO:0044281;phosphorus metabolic process#GO:0006793;negative regulation of biological process#GO:0048519;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;regulation of biological process#GO:0050789;purine-containing compound catabolic process#GO:0072523;nucleobase-containing small molecule metabolic process#GO:0055086;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;cyclic purine nucleotide metabolic process#GO:0052652;negative regulation of signal transduction#GO:0009968;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;organophosphate catabolic process#GO:0046434;purine nucleotide catabolic process#GO:0006195;regulation of cellular process#GO:0050794;nucleoside phosphate catabolic process#GO:1901292;catabolic process#GO:0009056;nucleoside phosphate metabolic process#GO:0006753;carbohydrate derivative catabolic process#GO:1901136;regulation of cell communication#GO:0010646;primary metabolic process#GO:0044238;purine ribonucleotide catabolic process#GO:0009154;nucleotide catabolic process#GO:0009166;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;cyclic nucleotide metabolic process#GO:0009187;negative regulation of response to stimulus#GO:0048585;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;nucleobase-containing compound catabolic process#GO:0034655;organophosphate metabolic process#GO:0019637;cGMP metabolic process#GO:0046068;carbohydrate derivative metabolic process#GO:1901135;ribonucleotide catabolic process#GO:0009261 hydrolase#PC00121;phosphodiesterase#PC00185 HUMAN|HGNC=11494|UniProtKB=P17600 P17600 SYN1 PTHR10841:SF24 SYNAPSIN SYNAPSIN-1 cytoskeletal adaptor activity#GO:0008093;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 cellular component organization or biogenesis#GO:0071840;vesicle-mediated transport in synapse#GO:0099003;establishment of localization#GO:0051234;synaptic vesicle cycle#GO:0099504;transport#GO:0006810;vesicle-mediated transport#GO:0016192;synaptic vesicle localization#GO:0097479;establishment of localization in cell#GO:0051649;vesicle localization#GO:0051648;cellular process#GO:0009987;localization#GO:0051179;cellular localization#GO:0051641;synapse organization#GO:0050808;organelle localization#GO:0051640;cell junction organization#GO:0034330;cellular component organization#GO:0016043 intracellular membrane-bounded organelle#GO:0043231;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;synaptic vesicle#GO:0008021;vesicle#GO:0031982;synaptic vesicle membrane#GO:0030672;intracellular vesicle#GO:0097708;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;transport vesicle membrane#GO:0030658;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;transport vesicle#GO:0030133;presynapse#GO:0098793;membrane#GO:0016020;secretory vesicle#GO:0099503;vesicle membrane#GO:0012506;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;cell junction#GO:0030054 membrane traffic protein#PC00150;membrane trafficking regulatory protein#PC00151 Synaptic vesicle trafficking#P05734>Synapsin#P05775 HUMAN|HGNC=33426|UniProtKB=B5MD39 B5MD39 GGTLC3 PTHR45027:SF5 PUTATIVE GLUTATHIONE HYDROLASE LIGHT CHAIN GLUTATHIONE HYDROLASE LIGHT CHAIN 2-RELATED hydrolase#PC00121 HUMAN|HGNC=6344|UniProtKB=Q9UEF7 Q9UEF7 KL PTHR10353:SF10 GLYCOSYL HYDROLASE KLOTHO growth factor binding#GO:0019838;hydrolase activity#GO:0016787;protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102;glucosidase activity#GO:0015926;fibroblast growth factor binding#GO:0017134;fibroblast growth factor receptor binding#GO:0005104;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824;beta-glucosidase activity#GO:0008422;growth factor receptor binding#GO:0070851 cellular response to growth factor stimulus#GO:0071363;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;response to growth factor#GO:0070848;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;cell surface receptor signaling pathway#GO:0007166;response to fibroblast growth factor#GO:0071774;biological regulation#GO:0065007;fibroblast growth factor receptor signaling pathway#GO:0008543;cellular response to fibroblast growth factor stimulus#GO:0044344;cellular process#GO:0009987;signal transduction#GO:0007165 metabolite interconversion enzyme#PC00262;glycosidase#PC00110;hydrolase#PC00121 HUMAN|HGNC=26570|UniProtKB=B1ANS9 B1ANS9 WDR64 PTHR44324:SF2 WD40 REPEAT DOMAIN 95 WD REPEAT-CONTAINING PROTEIN 64 HUMAN|HGNC=18999|UniProtKB=Q9BVS4 Q9BVS4 RIOK2 PTHR45852:SF1 SER/THR-PROTEIN KINASE RIO2 SERINE_THREONINE-PROTEIN KINASE RIO2 phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;protein kinase activity#GO:0004672;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;biosynthetic process#GO:0009058;maturation of SSU-rRNA#GO:0030490;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;ribosomal small subunit biogenesis#GO:0042274;metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840 cytosol#GO:0005829;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;preribosome#GO:0030684;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=23783|UniProtKB=Q8TCN5 Q8TCN5 ZNF507 PTHR24403:SF74 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 507 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=1030|UniProtKB=P30411 P30411 BDKRB2 PTHR24228:SF25 B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR B2 BRADYKININ RECEPTOR transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;signaling receptor activity#GO:0038023 system process#GO:0003008;regulation of anatomical structure size#GO:0090066;biological regulation#GO:0065007;blood circulation#GO:0008015;multicellular organismal process#GO:0032501;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of biological quality#GO:0065008;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;circulatory system process#GO:0003013;signaling#GO:0023052;vasodilation#GO:0042311;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GqPCR#P00730 HUMAN|HGNC=25161|UniProtKB=Q96EK2 Q96EK2 PHF21B PTHR24102:SF18 PHD FINGER PROTEIN PHD FINGER PROTEIN 21B HUMAN|HGNC=10760|UniProtKB=Q01105 Q01105 SET PTHR11875:SF67 TESTIS-SPECIFIC Y-ENCODED PROTEIN PROTEIN SET chromatin binding#GO:0003682;histone binding#GO:0042393;binding#GO:0005488;protein binding#GO:0005515 chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=11782|UniProtKB=P07101 P07101 TH PTHR11473:SF18 AROMATIC AMINO ACID HYDROXYLASE TYROSINE 3-MONOOXYGENASE catalytic activity#GO:0003824;monooxygenase activity#GO:0004497;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;oxidoreductase activity#GO:0016491 regulation of biological process#GO:0050789;phenol-containing compound metabolic process#GO:0018958;chemical synaptic transmission#GO:0007268;signaling#GO:0023052;reproductive process#GO:0022414;anterograde trans-synaptic signaling#GO:0098916;nervous system process#GO:0050877;cognition#GO:0050890;trans-synaptic signaling#GO:0099537;multicellular organismal reproductive process#GO:0048609;cell communication#GO:0007154;catecholamine metabolic process#GO:0006584;cellular process#GO:0009987;synaptic transmission, dopaminergic#GO:0001963;phenol-containing compound biosynthetic process#GO:0046189;amine metabolic process#GO:0009308;synaptic signaling#GO:0099536;biogenic amine metabolic process#GO:0006576;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;biosynthetic process#GO:0009058;multicellular organismal process#GO:0032501;metabolic process#GO:0008152;system process#GO:0003008 intracellular anatomical structure#GO:0005622;perikaryon#GO:0043204;axon#GO:0030424;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;somatodendritic compartment#GO:0036477;neuronal cell body#GO:0043025;cell projection#GO:0042995;neuron projection#GO:0043005;cell body#GO:0044297 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 Nicotine pharmacodynamics pathway#P06587>TH#P06614;Parkinson disease#P00049>TH#P01241;Adrenaline and noradrenaline biosynthesis#P00001>TH#P00062;Dopamine receptor mediated signaling pathway#P05912>TH#P05970 HUMAN|HGNC=20419|UniProtKB=Q15048 Q15048 LRRC14 PTHR14224:SF114 SIMILAR TO PREFERENTIALLY EXPRESSED ANTIGEN IN MELANOMA-LIKE 3 LEUCINE-RICH REPEAT-CONTAINING PROTEIN 14 protein binding#GO:0005515;ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme binding#GO:0019899;protein-macromolecule adaptor activity#GO:0030674;binding#GO:0005488;kinase binding#GO:0019900;enzyme-substrate adaptor activity#GO:0140767;molecular adaptor activity#GO:0060090 negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of signaling#GO:0023057;modification-dependent macromolecule catabolic process#GO:0043632;regulation of signaling#GO:0023051;protein catabolic process#GO:0030163;negative regulation of cell communication#GO:0010648;cellular process#GO:0009987;regulation of response to external stimulus#GO:0032101;proteasomal protein catabolic process#GO:0010498;negative regulation of signal transduction#GO:0009968;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;catabolic process#GO:0009056;regulation of response to biotic stimulus#GO:0002831;regulation of cell communication#GO:0010646;regulation of defense response#GO:0031347;regulation of immune response#GO:0050776;protein metabolic process#GO:0019538;negative regulation of response to stimulus#GO:0048585;negative regulation of immune system process#GO:0002683;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of cellular process#GO:0048523;regulation of response to stress#GO:0080134;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;regulation of response to stimulus#GO:0048583;regulation of innate immune response#GO:0045088;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511 cullin-RING ubiquitin ligase complex#GO:0031461;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;transferase complex#GO:1990234;Cul2-RING ubiquitin ligase complex#GO:0031462 HUMAN|HGNC=23215|UniProtKB=Q8TEQ8 Q8TEQ8 PIGO PTHR23071:SF1 PHOSPHATIDYLINOSITOL GLYCAN GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3, CATALYTIC SUBUNIT transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, for other substituted phosphate groups#GO:0016780;catalytic activity#GO:0003824;transferase activity#GO:0016740 phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phospholipid metabolic process#GO:0006644;glycerolipid metabolic process#GO:0046486;liposaccharide metabolic process#GO:1903509;GPI anchored protein biosynthesis#GO:0180046;phospholipid biosynthetic process#GO:0008654;glycolipid metabolic process#GO:0006664;glycolipid biosynthetic process#GO:0009247;protein metabolic process#GO:0019538;organophosphate biosynthetic process#GO:0090407;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;organophosphate metabolic process#GO:0019637;biosynthetic process#GO:0009058;glycerophospholipid metabolic process#GO:0006650;GPI anchor biosynthetic process#GO:0006506;lipid biosynthetic process#GO:0008610;gene expression#GO:0010467;protein maturation#GO:0051604;GPI anchor metabolic process#GO:0006505;glycerophospholipid biosynthetic process#GO:0046474;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;membrane#GO:0016020;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 HUMAN|HGNC=16313|UniProtKB=P60985 P60985 KRTDAP PTHR36463:SF1 KERATINOCYTE DIFFERENTIATION-ASSOCIATED PROTEIN KERATINOCYTE DIFFERENTIATION-ASSOCIATED PROTEIN anatomical structure development#GO:0048856;tissue development#GO:0009888;animal gross anatomical part developmental process#GO:0160108;epidermis development#GO:0008544;developmental process#GO:0032502 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=1085|UniProtKB=O60238 O60238 BNIP3L PTHR15186:SF3 RE48077P BCL2_ADENOVIRUS E1B 19 KDA PROTEIN-INTERACTING PROTEIN 3-LIKE process utilizing autophagic mechanism#GO:0061919;regulation of programmed cell death#GO:0043067;cellular component organization#GO:0016043;programmed cell death#GO:0012501;regulation of biological process#GO:0050789;cell death#GO:0008219;apoptotic process#GO:0006915;catabolic process#GO:0009056;positive regulation of programmed cell death#GO:0043068;regulation of cellular process#GO:0050794;metabolic process#GO:0008152;autophagy of mitochondrion#GO:0000422;regulation of apoptotic process#GO:0042981;positive regulation of apoptotic process#GO:0043065;mitophagy#GO:0000423;cellular component organization or biogenesis#GO:0071840;organelle organization#GO:0006996;autophagy#GO:0006914;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;biological regulation#GO:0065007;mitochondrion organization#GO:0007005;apoptotic mitochondrial changes#GO:0008637;macroautophagy#GO:0016236 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;organelle envelope#GO:0031967;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;outer membrane#GO:0019867;nuclear envelope#GO:0005635;cytoplasm#GO:0005737;organelle outer membrane#GO:0031968;endomembrane system#GO:0012505;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;nucleus#GO:0005634;membrane#GO:0016020;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;mitochondrial outer membrane#GO:0005741;endoplasmic reticulum#GO:0005783 HUMAN|HGNC=13966|UniProtKB=Q9GZK3 Q9GZK3 OR2B2 PTHR26453:SF254 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2B2 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 sensory perception#GO:0007600;nervous system process#GO:0050877;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;detection of chemical stimulus#GO:0009593;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;response to chemical#GO:0042221;response to stimulus#GO:0050896;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=9023|UniProtKB=Q13835 Q13835 PKP1 PTHR10372:SF3 PLAKOPHILLIN-RELATED PLAKOPHILIN-1 cell adhesion molecule binding#GO:0050839;binding#GO:0005488;protein binding#GO:0005515 cell-cell adhesion#GO:0098609;cellular process#GO:0009987;cell adhesion#GO:0007155 intracellular organelle#GO:0043229;cell junction#GO:0030054;adherens junction#GO:0005912;membrane-bounded organelle#GO:0043227;anchoring junction#GO:0070161;intracellular anatomical structure#GO:0005622;cell-cell junction#GO:0005911;membrane#GO:0016020;nucleus#GO:0005634;cell periphery#GO:0071944;organelle#GO:0043226;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 intermediate filament binding protein#PC00130;cytoskeletal protein#PC00085;intermediate filament#PC00129 HUMAN|HGNC=21115|UniProtKB=Q6P444 Q6P444 MTFR2 PTHR14215:SF2 PROTEIN OF UNKNOWN FUNCTION DUF729 MITOCHONDRIAL FISSION REGULATOR 2 cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;mitochondrion organization#GO:0007005;mitochondrial fission#GO:0000266;generation of precursor metabolites and energy#GO:0006091;metabolic process#GO:0008152;aerobic respiration#GO:0009060;energy derivation by oxidation of organic compounds#GO:0015980;cellular respiration#GO:0045333;organelle fission#GO:0048285;cellular component organization or biogenesis#GO:0071840 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739 HUMAN|HGNC=37245|UniProtKB=P0C6A0 P0C6A0 ZGLP1 PTHR47341:SF1 GATA-TYPE ZINC FINGER PROTEIN 1 GATA-TYPE ZINC FINGER PROTEIN 1 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of transcription by RNA polymerase II#GO:0045944;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA metabolic process#GO:0051252;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of DNA-templated transcription#GO:0006355;positive regulation of RNA metabolic process#GO:0051254;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=16390|UniProtKB=Q9Y239 Q9Y239 NOD1 PTHR24106:SF18 NACHT, LRR AND CARD DOMAINS-CONTAINING NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 1 signaling receptor activity#GO:0038023;molecular function inhibitor activity#GO:0140678;molecular function regulator activity#GO:0098772;pattern recognition receptor activity#GO:0038187;molecular transducer activity#GO:0060089 immune response-activating signaling pathway#GO:0002757;positive regulation of canonical NF-kappaB signal transduction#GO:0043123;positive regulation of response to external stimulus#GO:0032103;regulation of response to external stimulus#GO:0032101;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;signal transduction#GO:0007165;cellular process#GO:0009987;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;positive regulation of immune system process#GO:0002684;positive regulation of signaling#GO:0023056;defense response to bacterium#GO:0042742;regulation of signaling#GO:0023051;immune system process#GO:0002376;regulation of intracellular signal transduction#GO:1902531;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;immune response-regulating signaling pathway#GO:0002764;response to external stimulus#GO:0009605;positive regulation of response to biotic stimulus#GO:0002833;pattern recognition receptor signaling pathway#GO:0002221;defense response#GO:0006952;regulation of innate immune response#GO:0045088;positive regulation of immune response#GO:0050778;positive regulation of defense response#GO:0031349;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;regulation of response to stress#GO:0080134;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;response to other organism#GO:0051707;positive regulation of response to stimulus#GO:0048584;positive regulation of cellular process#GO:0048522;positive regulation of innate immune response#GO:0045089;regulation of canonical NF-kappaB signal transduction#GO:0043122;activation of innate immune response#GO:0002218;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;regulation of immune response#GO:0050776;regulation of defense response#GO:0031347;response to bacterium#GO:0009617;response to external biotic stimulus#GO:0043207;regulation of response to biotic stimulus#GO:0002831;regulation of cell communication#GO:0010646;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;innate immune response-activating signaling pathway#GO:0002758 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 scaffold/adaptor protein#PC00226 HUMAN|HGNC=34519|UniProtKB=O60290 O60290 ZNF862 PTHR46880:SF3 RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN ZINC FINGER PROTEIN 862 HUMAN|HGNC=173|UniProtKB=P27037 P27037 ACVR2A PTHR23255:SF64 TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II ACTIVIN RECEPTOR TYPE-2A transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity, acting on a protein#GO:0140096;molecular transducer activity#GO:0060089;activin binding#GO:0048185;kinase activity#GO:0016301;transferase activity#GO:0016740;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;protein serine/threonine kinase activity#GO:0004674;binding#GO:0005488;protein kinase activity#GO:0004672;protein-containing complex binding#GO:0044877;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein serine/threonine kinase activity#GO:0004675 multicellular organism development#GO:0007275;cell surface receptor signaling pathway#GO:0007166;developmental process#GO:0032502;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;cellular process#GO:0009987;signal transduction#GO:0007165;cellular response to growth factor stimulus#GO:0071363;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;cell communication#GO:0007154;activin receptor signaling pathway#GO:0032924;pattern specification process#GO:0007389;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;response to growth factor#GO:0070848;cellular response to endogenous stimulus#GO:0071495;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane protein complex#GO:0098796;membrane#GO:0016020;serine/threonine protein kinase complex#GO:1902554;protein kinase complex#GO:1902911;transferase complex#GO:1990234;catalytic complex#GO:1902494;signaling receptor complex#GO:0043235;transferase complex, transferring phosphorus-containing groups#GO:0061695 serine/threonine protein kinase receptor#PC00205 TGF-beta signaling pathway#P00052>TGFbetareceptor II#P01277;Gonadotropin-releasing hormone receptor pathway#P06664>ActRII/IIB#P06780;TGF-beta signaling pathway#P00052>TGFbetareceptors#P01283;Gonadotropin-releasing hormone receptor pathway#P06664>ActRII#P06747 HUMAN|HGNC=13877|UniProtKB=Q9BSA4 Q9BSA4 TTYH2 PTHR12424:SF6 TWEETY-RELATED PROTEIN TWEETY HOMOLOG 2 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic anion transmembrane transporter activity#GO:0008509;ligand-gated channel activity#GO:0022834;chloride transmembrane transporter activity#GO:0015108;passive transmembrane transporter activity#GO:0022803;chloride channel activity#GO:0005254;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;channel activity#GO:0015267;monoatomic anion channel activity#GO:0005253 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HUMAN|HGNC=30343|UniProtKB=O75165 O75165 DNAJC13 PTHR36983:SF2 DNAJ HOMOLOG SUBFAMILY C MEMBER 13 DNAJ HOMOLOG SUBFAMILY C MEMBER 13 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 localization#GO:0051179;establishment of localization#GO:0051234;import into cell#GO:0098657;receptor-mediated endocytosis#GO:0006898;transport#GO:0006810;endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987 bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;membrane#GO:0016020;vesicle membrane#GO:0012506;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endosome membrane#GO:0010008;endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular vesicle#GO:0097708 chaperone#PC00072 HUMAN|HGNC=23725|UniProtKB=Q5T5U3 Q5T5U3 ARHGAP21 PTHR23175:SF16 PDZ DOMAIN-CONTAINING PROTEIN RHO GTPASE-ACTIVATING PROTEIN 21 molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;enzyme activator activity#GO:0008047 microtubule-based transport#GO:0099111;organelle localization#GO:0051640;localization#GO:0051179;cellular localization#GO:0051641;Golgi organization#GO:0007030;cellular component organization#GO:0016043;establishment of organelle localization#GO:0051656;microtubule-based movement#GO:0007018;transport#GO:0006810;intracellular transport#GO:0046907;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle organization#GO:0006996;endomembrane system organization#GO:0010256;organelle transport along microtubule#GO:0072384;cytoskeleton-dependent intracellular transport#GO:0030705 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;actin cytoskeleton#GO:0015629;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;cell junction#GO:0030054;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;Golgi apparatus#GO:0005794 HUMAN|HGNC=24449|UniProtKB=Q9NPA8 Q9NPA8 ENY2 PTHR12514:SF1 ENHANCER OF YELLOW 2 TRANSCRIPTION FACTOR TRANSCRIPTION AND MRNA EXPORT FACTOR ENY2 transcription coactivator activity#GO:0003713;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 nucleobase-containing compound transport#GO:0015931;regulation of macromolecule metabolic process#GO:0060255;RNA transport#GO:0050658;regulation of cellular process#GO:0050794;RNA localization#GO:0006403;mRNA transport#GO:0051028;establishment of RNA localization#GO:0051236;localization#GO:0051179;regulation of DNA-templated transcription#GO:0006355;nucleic acid transport#GO:0050657;nuclear transport#GO:0051169;regulation of RNA metabolic process#GO:0051252;nuclear export#GO:0051168;nucleocytoplasmic transport#GO:0006913;regulation of nucleobase-containing compound metabolic process#GO:0019219;biosynthetic process#GO:0009058;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;macromolecule localization#GO:0033036;nitrogen compound transport#GO:0071705;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;macromolecule biosynthetic process#GO:0009059;poly(A)+ mRNA export from nucleus#GO:0016973;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;establishment of localization#GO:0051234;regulation of gene expression#GO:0010468;RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907;transport#GO:0006810;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;cellular localization#GO:0051641;mRNA export from nucleus#GO:0006406;gene expression#GO:0010467;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;metabolic process#GO:0008152 SAGA-type complex#GO:0070461;acetyltransferase complex#GO:1902493;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;protein acetyltransferase complex#GO:0031248;organelle#GO:0043226;cellular anatomical structure#GO:0110165;transcription export complex 2#GO:0070390;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;histone acetyltransferase complex#GO:0000123;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;peptidase complex#GO:1905368;SAGA complex#GO:0000124;DUBm complex#GO:0071819;chromatin#GO:0000785;nucleus#GO:0005634 DNA-binding transcription factor#PC00218 HUMAN|HGNC=11470|UniProtKB=Q7KZ85 Q7KZ85 SUPT6H PTHR10145:SF6 TRANSCRIPTION ELONGATION FACTOR SPT6 TRANSCRIPTION ELONGATION FACTOR SPT6 protein binding#GO:0005515;protein-containing complex binding#GO:0044877;nucleosome binding#GO:0031491;binding#GO:0005488;chromatin binding#GO:0003682;histone binding#GO:0042393 nucleobase-containing compound metabolic process#GO:0006139;chromatin organization#GO:0006325;biosynthetic process#GO:0009058;gene expression#GO:0010467;transcription elongation by RNA polymerase II#GO:0006368;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;DNA-templated transcription elongation#GO:0006354;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;nucleosome organization#GO:0034728;macromolecule metabolic process#GO:0043170;protein-DNA complex organization#GO:0071824;transcription by RNA polymerase II#GO:0006366;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;chromatin remodeling#GO:0006338;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187 cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;protein-containing complex#GO:0032991;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;transcription elongation factor complex#GO:0008023;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 general transcription factor#PC00259;RNA metabolism protein#PC00031 HUMAN|HGNC=2849|UniProtKB=P23743 P23743 DGKA PTHR11255:SF38 DIACYLGLYCEROL KINASE DIACYLGLYCEROL KINASE ALPHA lipid kinase activity#GO:0001727;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824 signaling#GO:0023052;phospholipid metabolic process#GO:0006644;phospholipid biosynthetic process#GO:0008654;regulation of cellular process#GO:0050794;glycerolipid metabolic process#GO:0046486;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;intracellular signal transduction#GO:0035556;organophosphate biosynthetic process#GO:0090407;cell communication#GO:0007154;biological regulation#GO:0065007;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;glycerophospholipid metabolic process#GO:0006650;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;signal transduction#GO:0007165;organophosphate metabolic process#GO:0019637;neutral lipid metabolic process#GO:0006638;lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474;acylglycerol metabolic process#GO:0006639;metabolic process#GO:0008152 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 kinase#PC00137;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=29834|UniProtKB=Q8WUS8 Q8WUS8 SDR42E1 PTHR10366:SF816 NAD DEPENDENT EPIMERASE/DEHYDRATASE SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E MEMBER 1 oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824 lyase#PC00144;dehydratase#PC00091;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=30258|UniProtKB=Q9BRP8 Q9BRP8 PYM1 PTHR22959:SF0 PYM PROTEIN PARTNER OF Y14 AND MAGO RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 protein-containing complex organization#GO:0043933;protein-containing complex disassembly#GO:0032984;cellular component disassembly#GO:0022411;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;exon-exon junction complex#GO:0035145;nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 HUMAN|HGNC=29800|UniProtKB=Q70IA8 Q70IA8 MOB3C PTHR22599:SF12 MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB MOB KINASE ACTIVATOR 3C protein kinase regulator activity#GO:0019887;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;protein kinase activator activity#GO:0030295;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;kinase activator activity#GO:0019209 cell communication#GO:0007154;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 kinase activator#PC00138 HUMAN|HGNC=2044|UniProtKB=Q8N7P3 Q8N7P3 CLDN22 PTHR12002:SF224 CLAUDIN CLAUDIN-22 cell junction organization#GO:0034330;cellular component assembly#GO:0022607;cellular process#GO:0009987;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;cell junction assembly#GO:0034329;cellular component organization or biogenesis#GO:0071840;cell-cell junction assembly#GO:0007043;cell-cell junction organization#GO:0045216 cellular anatomical structure#GO:0110165;bicellular tight junction#GO:0005923;plasma membrane#GO:0005886;membrane#GO:0016020;cell-cell junction#GO:0005911;cell periphery#GO:0071944;tight junction#GO:0070160;cell junction#GO:0030054;anchoring junction#GO:0070161;apical junction complex#GO:0043296 tight junction#PC00214;cell junction protein#PC00070 HUMAN|HGNC=24596|UniProtKB=Q96FJ2 Q96FJ2 DYNLL2 PTHR11886:SF113 DYNEIN LIGHT CHAIN DYNEIN LIGHT CHAIN 2, CYTOPLASMIC microtubule or microtubule-binding cytoskeletal protein#PC00157 Huntington disease#P00029>Dynein complex#P00774 HUMAN|HGNC=1869|UniProtKB=P11597 P11597 CETP PTHR47616:SF1 CHOLESTERYL ESTER TRANSFER PROTEIN CHOLESTERYL ESTER TRANSFER PROTEIN lipid binding#GO:0008289;cholesterol binding#GO:0015485;cation binding#GO:0043169;ion binding#GO:0043167;sterol binding#GO:0032934;small molecule binding#GO:0036094;binding#GO:0005488;phosphatidylcholine binding#GO:0031210;steroid binding#GO:0005496;alcohol binding#GO:0043178;phospholipid binding#GO:0005543 homeostatic process#GO:0042592;phospholipid metabolic process#GO:0006644;primary metabolic process#GO:0044238;localization#GO:0051179;triglyceride homeostasis#GO:0070328;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;lipid transport#GO:0006869;organophosphate metabolic process#GO:0019637;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;sterol metabolic process#GO:0016125;cholesterol homeostasis#GO:0042632;neutral lipid metabolic process#GO:0006638;transport#GO:0006810;triglyceride metabolic process#GO:0006641;lipid metabolic process#GO:0006629;cholesterol metabolic process#GO:0008203;acylglycerol metabolic process#GO:0006639;secondary alcohol metabolic process#GO:1902652;small molecule metabolic process#GO:0044281;glycerolipid metabolic process#GO:0046486;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;lipid homeostasis#GO:0055088;phosphorus metabolic process#GO:0006793;lipid localization#GO:0010876;steroid metabolic process#GO:0008202;glycerophospholipid metabolic process#GO:0006650;phosphatidylcholine metabolic process#GO:0046470;cellular process#GO:0009987;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;chemical homeostasis#GO:0048878;alcohol metabolic process#GO:0006066;metabolic process#GO:0008152 extracellular region#GO:0005576;extracellular protein-containing complex#GO:0140392;protein-lipid complex#GO:0032994;lipoprotein particle#GO:1990777;plasma lipoprotein particle#GO:0034358;high-density lipoprotein particle#GO:0034364;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 CCKR signaling map#P06959>CETP#P07189 HUMAN|HGNC=13239|UniProtKB=P58658 P58658 EVA1C PTHR46780:SF4 PROTEIN EVA-1 PROTEIN EVA-1 HOMOLOG C heparin binding#GO:0008201;carbohydrate derivative binding#GO:0097367;glycosaminoglycan binding#GO:0005539;binding#GO:0005488 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=10317|UniProtKB=P62750 P62750 RPL23A PTHR11620:SF60 60S RIBOSOMAL PROTEIN L23A LARGE RIBOSOMAL SUBUNIT PROTEIN UL23 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625;cytosol#GO:0005829;ribosome#GO:0005840 ribosomal protein#PC00202;translational protein#PC00263 HUMAN|HGNC=6234|UniProtKB=Q96PR1 Q96PR1 KCNC2 PTHR11537:SF172 VOLTAGE-GATED POTASSIUM CHANNEL VOLTAGE-GATED POTASSIUM CHANNEL KCNC2 voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;potassium channel activity#GO:0005267;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261 monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;metal ion transport#GO:0030001;action potential#GO:0001508;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;transport#GO:0006810;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813;cellular process#GO:0009987 dendrite#GO:0030425;dendritic tree#GO:0097447;axon#GO:0030424;transmembrane transporter complex#GO:1902495;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;plasma membrane bounded cell projection#GO:0120025;distal axon#GO:0150034;neuron projection terminus#GO:0044306;neuronal cell body#GO:0043025;neuron projection membrane#GO:0032589;voltage-gated potassium channel complex#GO:0008076;axon terminus#GO:0043679;membrane#GO:0016020;cell periphery#GO:0071944;monoatomic ion channel complex#GO:0034702;plasma membrane region#GO:0098590;presynaptic membrane#GO:0042734;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;postsynaptic membrane#GO:0045211;leading edge membrane#GO:0031256;cell projection membrane#GO:0031253;postsynapse#GO:0098794;cell body#GO:0044297;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;synaptic membrane#GO:0097060;cation channel complex#GO:0034703;transporter complex#GO:1990351;cell junction#GO:0030054;cell leading edge#GO:0031252;neuron projection#GO:0043005;presynapse#GO:0098793;protein-containing complex#GO:0032991 ion channel#PC00133;voltage-gated ion channel#PC00241 HUMAN|HGNC=23154|UniProtKB=Q7Z7K2 Q7Z7K2 ZNF467 PTHR24377:SF1040 IP01015P-RELATED ZINC FINGER PROTEIN 467 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=2538|UniProtKB=O60911 O60911 CTSV PTHR12411:SF57 CYSTEINE PROTEASE FAMILY C1-RELATED CATHEPSIN L2 cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;cysteine-type endopeptidase activity#GO:0004197;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096 cellular process#GO:0009987;primary metabolic process#GO:0044238;catabolic process#GO:0009056;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;vacuole#GO:0005773;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;extracellular region#GO:0005576;intracellular organelle#GO:0043229 cysteine protease#PC00081;protein modifying enzyme#PC00260;protease#PC00190 HUMAN|HGNC=7614|UniProtKB=P54296 P54296 MYOM2 PTHR13817:SF22 TITIN MYOMESIN-2 structural molecule activity#GO:0005198 cellular anatomical entity morphogenesis#GO:0032989;developmental process#GO:0032502;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;striated muscle cell differentiation#GO:0051146;anatomical structure formation involved in morphogenesis#GO:0048646;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;animal gross anatomical part developmental process#GO:0160108;cellular component assembly involved in morphogenesis#GO:0010927;organelle assembly#GO:0070925;actin filament-based process#GO:0030029;sarcomere organization#GO:0045214;anatomical structure development#GO:0048856;striated muscle cell development#GO:0055002;supramolecular fiber organization#GO:0097435;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;muscle cell development#GO:0055001;anatomical structure morphogenesis#GO:0009653;muscle cell differentiation#GO:0042692;myofibril assembly#GO:0030239;muscle structure development#GO:0061061;actin cytoskeleton organization#GO:0030036;cell differentiation#GO:0030154;cell development#GO:0048468;actomyosin structure organization#GO:0031032 cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;organelle#GO:0043226;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;A band#GO:0031672;contractile muscle fiber#GO:0043292;membraneless organelle#GO:0043228;myofibril#GO:0030016;sarcomere#GO:0030017;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;M band#GO:0031430;intracellular organelle#GO:0043229 structural protein#PC00211 HUMAN|HGNC=4820|UniProtKB=O00219 O00219 HAS3 PTHR22913:SF6 HYALURONAN SYNTHASE HYALURONAN SYNTHASE 3 UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758 carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;biosynthetic process#GO:0009058;carbohydrate biosynthetic process#GO:0016051;cellular component assembly#GO:0022607;extracellular matrix assembly#GO:0085029;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;glycosaminoglycan biosynthetic process#GO:0006024;carbohydrate derivative biosynthetic process#GO:1901137;aminoglycan biosynthetic process#GO:0006023;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;glycosaminoglycan metabolic process#GO:0030203;carbohydrate metabolic process#GO:0005975;polysaccharide metabolic process#GO:0005976;polysaccharide biosynthetic process#GO:0000271;aminoglycan metabolic process#GO:0006022;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transferase#PC00220;glycosyltransferase#PC00111 HUMAN|HGNC=566|UniProtKB=O00203 O00203 AP3B1 PTHR11134:SF10 ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER AP-3 COMPLEX SUBUNIT BETA-1 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 cytoskeleton-dependent intracellular transport#GO:0030705;vesicle localization#GO:0051648;axo-dendritic transport#GO:0008088;vesicle cytoskeletal trafficking#GO:0099518;anterograde synaptic vesicle transport#GO:0048490;transport along microtubule#GO:0010970;establishment of localization#GO:0051234;lytic vacuole organization#GO:0080171;transport#GO:0006810;vacuolar transport#GO:0007034;vesicle transport along microtubule#GO:0047496;intracellular transport#GO:0046907;microtubule-based movement#GO:0007018;anterograde axonal transport#GO:0008089;vacuole organization#GO:0007033;Golgi to vacuole transport#GO:0006896;localization#GO:0051179;pigmentation#GO:0043473;organelle localization#GO:0051640;axonal transport#GO:0098930;organelle transport along microtubule#GO:0072384;cellular pigmentation#GO:0033059;establishment of vesicle localization#GO:0051650;vesicle-mediated transport#GO:0016192;synaptic vesicle localization#GO:0097479;cellular process#GO:0009987;lysosome organization#GO:0007040;establishment of localization in cell#GO:0051649;synaptic vesicle transport#GO:0048489;organelle organization#GO:0006996;microtubule-based process#GO:0007017;vesicle organization#GO:0016050;cellular component organization or biogenesis#GO:0071840;Golgi vesicle transport#GO:0048193;melanosome organization#GO:0032438;establishment of organelle localization#GO:0051656;cellular component organization#GO:0016043;post-Golgi vesicle-mediated transport#GO:0006892;cellular localization#GO:0051641;microtubule-based transport#GO:0099111 AP-type membrane coat adaptor complex#GO:0030119;intracellular anatomical structure#GO:0005622;coated membrane#GO:0048475;membrane coat#GO:0030117;membrane protein complex#GO:0098796;membrane#GO:0016020;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 membrane traffic protein#PC00150 HUMAN|HGNC=10504|UniProtKB=P25815 P25815 S100P PTHR11639:SF139 S100 CALCIUM-BINDING PROTEIN PROTEIN S100-P calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;cation binding#GO:0043169;protein binding#GO:0005515;metal ion binding#GO:0046872 cell motility#GO:0048870;endothelial cell migration#GO:0043542;cell migration#GO:0016477;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 calmodulin-related#PC00061;calcium-binding protein#PC00060 HUMAN|HGNC=21725|UniProtKB=Q7Z4T8 Q7Z4T8 GALNTL5 PTHR11675:SF17 N-ACETYLGALACTOSAMINYLTRANSFERASE INACTIVE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE-LIKE PROTEIN 5 signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515;polypeptide N-acetylgalactosaminyltransferase activity#GO:0004653;catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758;acetylgalactosaminyltransferase activity#GO:0008376;glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194;catalytic activity, acting on a protein#GO:0140096 developmental process involved in reproduction#GO:0003006;primary metabolic process#GO:0044238;germ cell development#GO:0007281;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;reproductive process#GO:0022414;regulation of Notch signaling pathway#GO:0008593;spermatid development#GO:0007286;sexual reproduction#GO:0019953;protein metabolic process#GO:0019538;anatomical structure development#GO:0048856;multicellular organismal reproductive process#GO:0048609;glycoprotein biosynthetic process#GO:0009101;macromolecule biosynthetic process#GO:0009059;protein O-linked glycosylation#GO:0006493;carbohydrate derivative metabolic process#GO:1901135;male gamete generation#GO:0048232;biosynthetic process#GO:0009058;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of response to stimulus#GO:0048583;developmental process#GO:0032502;spermatogenesis#GO:0007283;cellular developmental process#GO:0048869;macromolecule metabolic process#GO:0043170;regulation of biological process#GO:0050789;gamete generation#GO:0007276;cell differentiation#GO:0030154;cell development#GO:0048468;cellular process involved in reproduction in multicellular organism#GO:0022412;spermatid differentiation#GO:0048515;regulation of signaling#GO:0023051;cellular process#GO:0009987;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;carbohydrate derivative biosynthetic process#GO:1901137 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 transferase#PC00220;glycosyltransferase#PC00111 HUMAN|HGNC=23917|UniProtKB=Q15415 Q15415 RBMY1F PTHR48034:SF17 TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED RNA-BINDING MOTIF PROTEIN, Y CHROMOSOME, FAMILY 1 MEMBER A1-RELATED binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723 mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 spliceosomal complex#GO:0005681;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HUMAN|HGNC=29916|UniProtKB=Q9UHQ1 Q9UHQ1 NARF PTHR11615:SF124 NITRATE, FORMATE, IRON DEHYDROGENASE NUCLEAR PRELAMIN A RECOGNITION FACTOR binding#GO:0005488;protein binding#GO:0005515 cellular component assembly#GO:0022607;cellular component organization or biogenesis#GO:0071840;iron-sulfur cluster assembly#GO:0016226;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;cellular process#GO:0009987 supramolecular fiber#GO:0099512;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear periphery#GO:0034399;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;organelle lumen#GO:0043233;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;intermediate filament#GO:0005882;intracellular protein-containing complex#GO:0140535;cytoskeleton#GO:0005856;supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;endomembrane system#GO:0012505;nuclear envelope#GO:0005635;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=8467|UniProtKB=Q8NG95 Q8NG95 OR7G3 PTHR48001:SF123 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 7G3 transmembrane signal receptor#PC00197 HUMAN|HGNC=1579|UniProtKB=P14635 P14635 CCNB1 PTHR10177:SF193 CYCLINS G2_MITOTIC-SPECIFIC CYCLIN-B1 cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;cyclin-dependent protein kinase regulator activity#GO:0019914;protein kinase regulator activity#GO:0019887 cell cycle#GO:0007049;sister chromatid segregation#GO:0000819;cellular component organization#GO:0016043;nuclear chromosome segregation#GO:0098813;mitotic metaphase chromosome alignment#GO:0007080;mitotic nuclear division#GO:0140014;cell cycle process#GO:0022402;mitotic cell cycle#GO:0000278;cell cycle phase transition#GO:0044770;mitotic cell cycle phase transition#GO:0044772;nuclear division#GO:0000280;organelle localization#GO:0051640;localization#GO:0051179;organelle fission#GO:0048285;organelle organization#GO:0006996;mitotic sister chromatid segregation#GO:0000070;cell cycle G1/S phase transition#GO:0044843;cellular process#GO:0009987;chromosome localization#GO:0050000;metaphase chromosome alignment#GO:0051310;G1/S transition of mitotic cell cycle#GO:0000082;chromosome segregation#GO:0007059;cellular component organization or biogenesis#GO:0071840;mitotic cell cycle process#GO:1903047;chromosome organization#GO:0051276 protein-containing complex#GO:0032991;cytoplasm#GO:0005737;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein kinase complex#GO:1902911;transferase complex#GO:1990234;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;catalytic complex#GO:1902494 kinase activator#PC00138 p53 pathway#P00059>Cyclin B#P04614;Cell cycle#P00013>Cyclin B#P00486 HUMAN|HGNC=5195|UniProtKB=Q9Y278 Q9Y278 HS3ST2 PTHR10605:SF10 HEPARAN SULFATE SULFOTRANSFERASE HEPARAN SULFATE GLUCOSAMINE 3-O-SULFOTRANSFERASE 2 transferase activity, transferring sulphur-containing groups#GO:0016782;sulfotransferase activity#GO:0008146;transferase activity#GO:0016740;catalytic activity#GO:0003824 transferase#PC00220;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=9678|UniProtKB=Q16827 Q16827 PTPRO PTHR47028:SF1 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE O RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE O phosphoprotein phosphatase activity#GO:0004721;protein binding#GO:0005515;protein tyrosine phosphatase activity#GO:0004725;hydrolase activity#GO:0016787;Wnt-protein binding#GO:0017147;binding#GO:0005488;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;phosphatase activity#GO:0016791;cell adhesion molecule binding#GO:0050839;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 negative regulation of response to stimulus#GO:0048585;tissue development#GO:0009888;multicellular organismal process#GO:0032501;negative regulation of Wnt signaling pathway#GO:0030178;epithelial cell differentiation#GO:0030855;epithelium development#GO:0060429;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;axon development#GO:0061564;axon guidance#GO:0007411;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;neuron projection guidance#GO:0097485;negative regulation of cellular process#GO:0048523;regulation of system process#GO:0044057;neuron projection morphogenesis#GO:0048812;regulation of response to stimulus#GO:0048583;developmental process#GO:0032502;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;anatomical structure development#GO:0048856;system development#GO:0048731;negative regulation of signal transduction#GO:0009968;cell morphogenesis involved in neuron differentiation#GO:0048667;regulation of multicellular organismal process#GO:0051239;nervous system development#GO:0007399;regulation of canonical Wnt signaling pathway#GO:0060828;kidney development#GO:0001822;renal system development#GO:0072001;neuron projection development#GO:0031175;cellular process#GO:0009987;animal organ development#GO:0048513;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cell projection morphogenesis#GO:0048858;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;cell morphogenesis#GO:0000902;cell differentiation#GO:0030154;cell projection organization#GO:0030030;regulation of Wnt signaling pathway#GO:0030111;cell development#GO:0048468;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;axonogenesis#GO:0007409;negative regulation of cell communication#GO:0010648;neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;negative regulation of signaling#GO:0023057;negative regulation of canonical Wnt signaling pathway#GO:0090090;regulation of signaling#GO:0023051;generation of neurons#GO:0048699 cell periphery#GO:0071944;membrane#GO:0016020;GABA-ergic synapse#GO:0098982;plasma membrane#GO:0005886;synapse#GO:0045202;cellular anatomical structure#GO:0110165;glutamatergic synapse#GO:0098978;cell junction#GO:0030054 transmembrane signal receptor#PC00197 HUMAN|HGNC=31088|UniProtKB=Q5I7T1 Q5I7T1 ALG10B PTHR12989:SF12 ALPHA-1,2-GLUCOSYLTRANSFERASE ALG10 DOL-P-GLC:GLC(2)MAN(9)GLCNAC(2)-PP-DOL ALPHA-1,2-GLUCOSYLTRANSFERASE B glucosyltransferase activity#GO:0046527;glycosyltransferase activity#GO:0016757;hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;biosynthetic process#GO:0009058;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 transferase#PC00220 HUMAN|HGNC=21571|UniProtKB=Q5VVB8 Q5VVB8 TMEM244 PTHR12952:SF1 SYS1 TRANSMEMBRANE PROTEIN 244-RELATED membrane traffic protein#PC00150 HUMAN|HGNC=23530|UniProtKB=Q9ULE6 Q9ULE6 PALD1 PTHR23339:SF96 TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE PALADIN phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protein modifying enzyme#PC00260;protein phosphatase#PC00195 HUMAN|HGNC=20994|UniProtKB=Q7Z7L9 Q7Z7L9 ZSCAN2 PTHR24381:SF467 ZINC FINGER PROTEIN ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 2 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=13285|UniProtKB=Q5HY92 Q5HY92 FIGN PTHR23074:SF14 AAA DOMAIN-CONTAINING FIDGETIN ATP-dependent activity#GO:0140657;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;polypeptide conformation or assembly isomerase activity#GO:0120544;ATP hydrolysis activity#GO:0016887;hydrolase activity#GO:0016787;macromolecular conformation isomerase activity#GO:0120543;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;isomerase activity#GO:0016853;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity, acting on a protein#GO:0140096 cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226;cytoskeleton organization#GO:0007010;microtubule-based process#GO:0007017;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 microtubule or microtubule-binding cytoskeletal protein#PC00157;non-motor microtubule binding protein#PC00166 HUMAN|HGNC=14674|UniProtKB=Q96QU1 Q96QU1 PCDH15 PTHR24028:SF11 CADHERIN-87A PROTOCADHERIN-15 multicellular organismal process#GO:0032501;visual perception#GO:0007601;sensory perception of sound#GO:0007605;sensory perception of light stimulus#GO:0050953;cellular process#GO:0009987;system process#GO:0003008;nervous system process#GO:0050877;sensory perception of mechanical stimulus#GO:0050954;sensory perception#GO:0007600;cell adhesion#GO:0007155 cell junction#GO:0030054;plasma membrane#GO:0005886;cell periphery#GO:0071944;photoreceptor cell cilium#GO:0097733;neuron projection#GO:0043005;membrane#GO:0016020;9+0 non-motile cilium#GO:0097731;non-motile cilium#GO:0097730;membrane-bounded organelle#GO:0043227;cilium#GO:0005929;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;photoreceptor outer segment#GO:0001750 cell adhesion molecule#PC00069;cadherin#PC00057 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HUMAN|HGNC=25117|UniProtKB=Q0D2K3 Q0D2K3 RIPPLY1 PTHR16770:SF5 PROTEIN RIPPLY-LIKE PROTEIN RIPPLY1 embryo development#GO:0009790;embryonic pattern specification#GO:0009880;negative regulation of macromolecule biosynthetic process#GO:0010558;multicellular organism development#GO:0007275;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;pattern specification process#GO:0007389 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=9704|UniProtKB=P20472 P20472 PVALB PTHR11653:SF2 PARVALBUMIN ALPHA PARVALBUMIN ALPHA calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;cation binding#GO:0043169;metal ion binding#GO:0046872 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 calmodulin-related#PC00061;calcium-binding protein#PC00060 HUMAN|HGNC=18215|UniProtKB=Q8TCG2 Q8TCG2 PI4K2B PTHR12865:SF6 PHOSPHATIDYLINOSITOL 4-KINASE TYPE-II PHOSPHATIDYLINOSITOL 4-KINASE TYPE 2-BETA transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;phosphatidylinositol kinase activity#GO:0052742;transferase activity, transferring phosphorus-containing groups#GO:0016772;lipid kinase activity#GO:0001727;phosphotransferase activity, alcohol group as acceptor#GO:0016773 glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987;organelle organization#GO:0006996;organophosphate metabolic process#GO:0019637;endomembrane system organization#GO:0010256;biosynthetic process#GO:0009058;glycerophospholipid metabolic process#GO:0006650;lipid biosynthetic process#GO:0008610;glycerophospholipid biosynthetic process#GO:0046474;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;vesicle organization#GO:0016050;endosome organization#GO:0007032;cellular component organization or biogenesis#GO:0071840;Golgi organization#GO:0007030;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;cellular component organization#GO:0016043;phospholipid metabolic process#GO:0006644;glycerolipid metabolic process#GO:0046486;phospholipid biosynthetic process#GO:0008654;phosphatidylinositol phosphate biosynthetic process#GO:0046854;organophosphate biosynthetic process#GO:0090407 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endosome#GO:0005768;plasma membrane#GO:0005886;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;endomembrane system#GO:0012505;cell periphery#GO:0071944;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;Golgi apparatus#GO:0005794 transferase#PC00220;kinase#PC00137;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=19388|UniProtKB=P49593 P49593 PPM1F PTHR13832:SF233 PROTEIN PHOSPHATASE 2C PROTEIN PHOSPHATASE 1F phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;hydrolase activity#GO:0016787;protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721 positive regulation of actin filament bundle assembly#GO:0032233;regulation of actin filament-based process#GO:0032970;positive regulation of cellular component biogenesis#GO:0044089;biological regulation#GO:0065007;regulation of actin cytoskeleton organization#GO:0032956;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;regulation of actin filament organization#GO:0110053;cellular process#GO:0009987;cell communication#GO:0007154;positive regulation of organelle organization#GO:0010638;positive regulation of cellular component organization#GO:0051130;regulation of cytoskeleton organization#GO:0051493;response to stimulus#GO:0050896;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of cellular component biogenesis#GO:0044087;regulation of stress fiber assembly#GO:0051492;regulation of actin filament bundle assembly#GO:0032231;regulation of supramolecular fiber organization#GO:1902903;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;cellular response to stimulus#GO:0051716 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cytosol#GO:0005829;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 protein phosphatase#PC00195 HUMAN|HGNC=374|UniProtKB=Q5JQC9 Q5JQC9 AKAP4 PTHR10226:SF8 A KINASE ANCHOR PROTEIN A-KINASE ANCHOR PROTEIN 4 binding#GO:0005488;protein kinase A binding#GO:0051018;protein binding#GO:0005515 cell surface receptor signaling pathway#GO:0007166;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;intracellular protein localization#GO:0008104;enzyme-linked receptor protein signaling pathway#GO:0007167;localization#GO:0051179;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;macromolecule localization#GO:0033036;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 9+2 motile cilium#GO:0097729;cilium#GO:0005929;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;sperm principal piece#GO:0097228;cell projection#GO:0042995;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;motile cilium#GO:0031514;organelle#GO:0043226;cellular anatomical structure#GO:0110165;sperm flagellum#GO:0036126 scaffold/adaptor protein#PC00226 HUMAN|HGNC=29314|UniProtKB=Q5VU97 Q5VU97 CACHD1 PTHR10166:SF68 VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED VWFA AND CACHE DOMAIN-CONTAINING PROTEIN 1 voltage-gated calcium channel activity#GO:0005245;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;calcium channel activity#GO:0005262;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;transporter activity#GO:0005215;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;calcium channel complex#GO:0034704;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;membrane#GO:0016020;voltage-gated calcium channel complex#GO:0005891;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;cation channel complex#GO:0034703 voltage-gated ion channel#PC00241;transporter#PC00227 HUMAN|HGNC=31305|UniProtKB=A6NM76 A6NM76 OR6C76 PTHR26454:SF18 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 6C76 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=12635|UniProtKB=P46939 P46939 UTRN PTHR12268:SF26 E3 UBIQUITIN-PROTEIN LIGASE KCMF1 UTROPHIN cellular component organization or biogenesis#GO:0071840;cell junction organization#GO:0034330;neuromuscular junction development#GO:0007528;cellular component organization#GO:0016043;synapse organization#GO:0050808;cellular process#GO:0009987 cell junction#GO:0030054;neuromuscular junction#GO:0031594;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;membrane#GO:0016020;dystrophin-associated glycoprotein complex#GO:0016010;plasma membrane#GO:0005886;cell projection#GO:0042995;protein-containing complex#GO:0032991;synapse#GO:0045202;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=2855|UniProtKB=O75912 O75912 DGKI PTHR11255:SF92 DIACYLGLYCEROL KINASE DIACYLGLYCEROL KINASE IOTA lipid kinase activity#GO:0001727;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824 neutral lipid metabolic process#GO:0006638;metabolic process#GO:0008152;acylglycerol metabolic process#GO:0006639;glycerophospholipid biosynthetic process#GO:0046474;lipid metabolic process#GO:0006629;glycerophospholipid metabolic process#GO:0006650;lipid biosynthetic process#GO:0008610;biological regulation#GO:0065007;biosynthetic process#GO:0009058;organophosphate metabolic process#GO:0019637;signal transduction#GO:0007165;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;cell communication#GO:0007154;organophosphate biosynthetic process#GO:0090407;intracellular signal transduction#GO:0035556;response to stimulus#GO:0050896;glycerolipid metabolic process#GO:0046486;regulation of cellular process#GO:0050794;phospholipid biosynthetic process#GO:0008654;phospholipid metabolic process#GO:0006644;signaling#GO:0023052;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716 plasma membrane#GO:0005886;glutamatergic synapse#GO:0098978;cellular anatomical structure#GO:0110165;synapse#GO:0045202;cell junction#GO:0030054;cell periphery#GO:0071944;membrane#GO:0016020 kinase#PC00137;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=16099|UniProtKB=Q6ZNI0 Q6ZNI0 GCNT7 PTHR19297:SF178 GLYCOSYLTRANSFERASE 14 FAMILY MEMBER BETA-1,3-GALACTOSYL-O-GLYCOSYL-GLYCOPROTEIN BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE 7-RELATED acetylglucosaminyltransferase activity#GO:0008375;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740 glycosyltransferase#PC00111 HUMAN|HGNC=16708|UniProtKB=Q8N5H3 Q8N5H3 FAM89B PTHR46949:SF2 LEUCINE REPEAT ADAPTER PROTEIN 25 LEUCINE REPEAT ADAPTER PROTEIN 25 protein binding#GO:0005515;transcription factor binding#GO:0008134;binding#GO:0005488 positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;positive regulation of cell migration#GO:0030335;biological regulation#GO:0065007;regulation of cellular response to growth factor stimulus#GO:0090287;regulation of signal transduction#GO:0009966;regulation of locomotion#GO:0040012;negative regulation of signal transduction#GO:0009968;negative regulation of response to stimulus#GO:0048585;regulation of cell migration#GO:0030334;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;positive regulation of locomotion#GO:0040017;establishment of cell polarity#GO:0030010;regulation of transforming growth factor beta receptor signaling pathway#GO:0017015;regulation of biological process#GO:0050789;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092;negative regulation of biological process#GO:0048519;positive regulation of cell motility#GO:2000147;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of signaling#GO:0023051;establishment or maintenance of cell polarity#GO:0007163;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;negative regulation of cell communication#GO:0010648;regulation of cell motility#GO:2000145;negative regulation of intracellular signal transduction#GO:1902532 cell leading edge#GO:0031252;cellular anatomical structure#GO:0110165;lamellipodium#GO:0030027;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cell projection#GO:0042995 scaffold/adaptor protein#PC00226 HUMAN|HGNC=3667|UniProtKB=Q92914 Q92914 FGF11 PTHR11486:SF67 FIBROBLAST GROWTH FACTOR FIBROBLAST GROWTH FACTOR 11 fibroblast growth factor receptor binding#GO:0005104;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;ion channel regulator activity#GO:0099106;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;growth factor receptor binding#GO:0070851;growth factor activity#GO:0008083;protein binding#GO:0005515;molecular function activator activity#GO:0140677;channel regulator activity#GO:0016247;signaling receptor binding#GO:0005102;binding#GO:0005488;transporter regulator activity#GO:0141108 multicellular organism development#GO:0007275;cell surface receptor signaling pathway#GO:0007166;regulation of MAPK cascade#GO:0043408;nervous system development#GO:0007399;cellular process#GO:0009987;cellular response to fibroblast growth factor stimulus#GO:0044344;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;positive regulation of signaling#GO:0023056;cellular response to growth factor stimulus#GO:0071363;regulation of intracellular signal transduction#GO:1902531;animal gross anatomical part developmental process#GO:0160108;regulation of signaling#GO:0023051;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;cell differentiation#GO:0030154;signaling#GO:0023052;response to endogenous stimulus#GO:0009719;positive regulation of cell population proliferation#GO:0008284;regulation of biological process#GO:0050789;positive regulation of MAPK cascade#GO:0043410;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;response to fibroblast growth factor#GO:0071774;regulation of response to stimulus#GO:0048583;regulation of cell migration#GO:0030334;positive regulation of intracellular signal transduction#GO:1902533;developmental process#GO:0032502;multicellular organismal process#GO:0032501;fibroblast growth factor receptor signaling pathway#GO:0008543;positive regulation of response to stimulus#GO:0048584;regulation of locomotion#GO:0040012;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of cellular process#GO:0048522;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;regulation of cell motility#GO:2000145;regulation of cell population proliferation#GO:0042127;system development#GO:0048731;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;response to growth factor#GO:0070848;regulation of cell communication#GO:0010646;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;extracellular region#GO:0005576;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 growth factor#PC00112;intercellular signal molecule#PC00207 FGF signaling pathway#P00021>FGF#P00623 HUMAN|HGNC=6430|UniProtKB=P05783 P05783 KRT18 PTHR23239:SF349 INTERMEDIATE FILAMENT KERATIN, TYPE I CYTOSKELETAL 18 cytoskeleton organization#GO:0007010;intermediate filament cytoskeleton organization#GO:0045104;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;intermediate filament-based process#GO:0045103;organelle organization#GO:0006996;cellular component organization#GO:0016043 intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;organelle#GO:0043226;supramolecular complex#GO:0099080;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;intermediate filament#GO:0005882;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228 intermediate filament#PC00129 HUMAN|HGNC=8495|UniProtKB=Q9Y267 Q9Y267 SLC22A14 PTHR24064:SF48 SOLUTE CARRIER FAMILY 22 MEMBER SOLUTE CARRIER FAMILY 22 MEMBER 14 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 secondary carrier transporter#PC00258 HUMAN|HGNC=25730|UniProtKB=Q5W5X9 Q5W5X9 TTC23 PTHR14485:SF3 TETRATRICOPEPTIDE REPEAT PROTEIN 23 TETRATRICOPEPTIDE REPEAT PROTEIN 23 HUMAN|HGNC=27015|UniProtKB=Q5EBM0 Q5EBM0 CMPK2 PTHR10344:SF5 THYMIDYLATE KINASE UMP-CMP KINASE 2, MITOCHONDRIAL kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;nucleobase-containing compound kinase activity#GO:0019205;catalytic activity#GO:0003824;transferase activity#GO:0016740;phosphotransferase activity, phosphate group as acceptor#GO:0016776;nucleoside diphosphate kinase activity#GO:0004550 biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;carbohydrate derivative metabolic process#GO:1901135;pyrimidine-containing compound metabolic process#GO:0072527;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;nucleobase-containing small molecule metabolic process#GO:0055086;nucleoside phosphate biosynthetic process#GO:1901293;carbohydrate derivative biosynthetic process#GO:1901137;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;nucleotide biosynthetic process#GO:0009165;nucleotide metabolic process#GO:0009117;organophosphate biosynthetic process#GO:0090407;nucleoside diphosphate metabolic process#GO:0009132 mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 transferase#PC00220;kinase#PC00137;nucleotide kinase#PC00172 HUMAN|HGNC=4503|UniProtKB=Q9Y5Y3 Q9Y5Y3 GPR45 PTHR24245:SF4 G-PROTEIN COUPLED RECEPTOR G PROTEIN-COUPLED RECEPTOR 45-RELATED G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GoPCR#P00725 HUMAN|HGNC=31853|UniProtKB=Q6DHV7 Q6DHV7 MAPDA PTHR11409:SF42 ADENOSINE DEAMINASE N6-METHYL-AMP DEAMINASE hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;adenosine deaminase activity#GO:0004000;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;deaminase activity#GO:0019239;catalytic activity#GO:0003824 small molecule biosynthetic process#GO:0044283;purine nucleobase metabolic process#GO:0006144;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleobase-containing small molecule metabolic process#GO:0055086;purine nucleoside catabolic process#GO:0006152;nucleobase metabolic process#GO:0009112;purine-containing compound catabolic process#GO:0072523;carbohydrate derivative biosynthetic process#GO:1901137;carbohydrate derivative metabolic process#GO:1901135;adenosine metabolic process#GO:0046085;cellular process#GO:0009987;nucleobase-containing compound catabolic process#GO:0034655;glycosyl compound catabolic process#GO:1901658;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;purine nucleoside metabolic process#GO:0042278;purine-containing compound biosynthetic process#GO:0072522;nucleoside catabolic process#GO:0009164;purine-containing compound metabolic process#GO:0072521;nucleobase-containing small molecule catabolic process#GO:0034656;primary metabolic process#GO:0044238;small molecule catabolic process#GO:0044282;carbohydrate derivative catabolic process#GO:1901136;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;nucleoside metabolic process#GO:0009116 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 deaminase#PC00088 Adenine and hypoxanthine salvage pathway#P02723>Adenosine deaminase#P02811;Adenine and hypoxanthine salvage pathway#P02723>Deoxyadenosine deaminase#P02807 HUMAN|HGNC=21042|UniProtKB=Q96E22 Q96E22 NUS1 PTHR21528:SF3 DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1 DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1 catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;prenyltransferase activity#GO:0004659 organophosphate metabolic process#GO:0019637;glycoprotein biosynthetic process#GO:0009101;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;glycoprotein metabolic process#GO:0009100;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;phospholipid biosynthetic process#GO:0008654;phospholipid metabolic process#GO:0006644;organophosphate biosynthetic process#GO:0090407;protein metabolic process#GO:0019538 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;endoplasmic reticulum subcompartment#GO:0098827;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum membrane#GO:0005789;transferase complex#GO:1990234;endoplasmic reticulum#GO:0005783;organelle membrane#GO:0031090;membrane#GO:0016020;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasm#GO:0005737 HUMAN|HGNC=2000|UniProtKB=P33552 P33552 CKS2 PTHR23415:SF48 CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7 CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT 2 kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;cyclin-dependent protein kinase regulator activity#GO:0019914;protein kinase regulator activity#GO:0019887;enzyme activator activity#GO:0008047;cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538;protein serine/threonine kinase activator activity#GO:0043539;protein kinase activator activity#GO:0030295;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;kinase activator activity#GO:0019209 mitotic cell cycle process#GO:1903047;cell cycle phase transition#GO:0044770;mitotic cell cycle#GO:0000278;cellular process#GO:0009987;cell cycle process#GO:0022402;mitotic cell cycle phase transition#GO:0044772;cell cycle#GO:0007049 ubiquitin ligase complex#GO:0000151;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;organelle#GO:0043226;SCF ubiquitin ligase complex#GO:0019005;intracellular membrane-bounded organelle#GO:0043231;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535;protein kinase complex#GO:1902911;transferase complex#GO:1990234;protein-containing complex#GO:0032991;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;nucleus#GO:0005634 scaffold/adaptor protein#PC00226 HUMAN|HGNC=28248|UniProtKB=P0CW24 P0CW24 PNMA6A PTHR23095:SF40 PARANEOPLASTIC ANTIGEN PARANEOPLASTIC ANTIGEN-LIKE PROTEIN 6A transcription cofactor#PC00217 HUMAN|HGNC=17440|UniProtKB=Q8NHY2 Q8NHY2 COP1 PTHR44080:SF1 E3 UBIQUITIN-PROTEIN LIGASE COP1 E3 UBIQUITIN-PROTEIN LIGASE COP1 transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 P53 pathway feedback loops 1#P04392>Cop-1#P04540;P53 pathway feedback loops 1#P04392>Cop-1#G04683 HUMAN|HGNC=9040|UniProtKB=Q13093 Q13093 PLA2G7 PTHR10272:SF12 PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;hydrolase activity#GO:0016787 protein modifying enzyme#PC00260 HUMAN|HGNC=6011|UniProtKB=P08700 P08700 IL3 PTHR48489:SF1 INTERLEUKIN-3 INTERLEUKIN-3 cytokine activity#GO:0005125;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772 cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to cytokine#GO:0034097;response to chemical#GO:0042221;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;cytokine-mediated signaling pathway#GO:0019221;cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;response to peptide#GO:1901652 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 Interleukin signaling pathway#P00036>Interleukin#P00970 HUMAN|HGNC=30435|UniProtKB=Q5SVJ3 Q5SVJ3 SPMIP3 PTHR31763:SF2 HYPOTHETICAL PROTEIN LOC689766 PROTEIN SPMIP3 HUMAN|HGNC=447|UniProtKB=O96006 O96006 ZBED1 PTHR46169:SF2 DNA REPLICATION-RELATED ELEMENT FACTOR, ISOFORM A E3 SUMO-PROTEIN LIGASE ZBED1 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA metabolism protein#PC00009 HUMAN|HGNC=5749|UniProtKB=A0A075B6S4 A0A075B6S4 IGKV1D-17 PTHR23267:SF514 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN KAPPA VARIABLE 1-16-RELATED immune system process#GO:0002376;immune response#GO:0006955;response to stimulus#GO:0050896 protein-containing complex#GO:0032991 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=17755|UniProtKB=Q96RJ3 Q96RJ3 TNFRSF13C PTHR20437:SF2 TUMOR NECROSIS FACTOR RECEPTOR SUBFAMILY MEMBER 13/17 TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 13C regulation of leukocyte cell-cell adhesion#GO:1903037;positive regulation of leukocyte proliferation#GO:0070665;regulation of cell adhesion#GO:0030155;regulation of lymphocyte proliferation#GO:0050670;positive regulation of cell activation#GO:0050867;positive regulation of leukocyte cell-cell adhesion#GO:1903039;biological regulation#GO:0065007;positive regulation of cellular process#GO:0048522;regulation of cell population proliferation#GO:0042127;positive regulation of lymphocyte activation#GO:0051251;positive regulation of lymphocyte proliferation#GO:0050671;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of cell-cell adhesion#GO:0022407;regulation of T cell proliferation#GO:0042129;positive regulation of B cell proliferation#GO:0030890;positive regulation of cell adhesion#GO:0045785;positive regulation of mononuclear cell proliferation#GO:0032946;regulation of leukocyte proliferation#GO:0070663;regulation of B cell proliferation#GO:0030888;positive regulation of leukocyte activation#GO:0002696;regulation of T cell activation#GO:0050863;positive regulation of T cell activation#GO:0050870;regulation of multicellular organismal process#GO:0051239;regulation of mononuclear cell proliferation#GO:0032944;positive regulation of immune system process#GO:0002684;regulation of B cell activation#GO:0050864;positive regulation of cell-cell adhesion#GO:0022409;positive regulation of biological process#GO:0048518;immune system process#GO:0002376;regulation of lymphocyte activation#GO:0051249;positive regulation of T cell proliferation#GO:0042102;regulation of leukocyte activation#GO:0002694;positive regulation of cell population proliferation#GO:0008284;regulation of cell activation#GO:0050865;positive regulation of multicellular organismal process#GO:0051240;regulation of biological process#GO:0050789 cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;plasma membrane#GO:0005886;membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=30040|UniProtKB=Q9BZM2 Q9BZM2 PLA2G2F PTHR11716:SF8 PHOSPHOLIPASE A2 FAMILY MEMBER GROUP IIF SECRETORY PHOSPHOLIPASE A2 phospholipid binding#GO:0005543;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;cation binding#GO:0043169;lipase activity#GO:0016298;small molecule binding#GO:0036094;ion binding#GO:0043167;carboxylic ester hydrolase activity#GO:0052689;A2-type glycerophospholipase activity#GO:0004623;glycerophospholipase activity#GO:0004620;phospholipase activity#GO:0120569;metal ion binding#GO:0046872;lipid binding#GO:0008289;binding#GO:0005488;calcium ion binding#GO:0005509 cellular process#GO:0009987;regulation of mononuclear cell proliferation#GO:0032944;negative regulation of leukocyte activation#GO:0002695;regulation of multicellular organismal process#GO:0051239;negative regulation of lymphocyte activation#GO:0051250;phosphatidylcholine metabolic process#GO:0046470;glycerophospholipid metabolic process#GO:0006650;negative regulation of cell-cell adhesion#GO:0022408;regulation of T cell activation#GO:0050863;metabolic process#GO:0008152;negative regulation of T cell proliferation#GO:0042130;regulation of leukocyte proliferation#GO:0070663;regulation of biological process#GO:0050789;regulation of cell activation#GO:0050865;negative regulation of biological process#GO:0048519;regulation of leukocyte activation#GO:0002694;phosphorus metabolic process#GO:0006793;regulation of lymphocyte activation#GO:0051249;glycerolipid metabolic process#GO:0046486;organophosphate metabolic process#GO:0019637;negative regulation of cell population proliferation#GO:0008285;negative regulation of immune system process#GO:0002683;biological regulation#GO:0065007;negative regulation of cell adhesion#GO:0007162;regulation of cell adhesion#GO:0030155;regulation of lymphocyte proliferation#GO:0050670;lipid metabolic process#GO:0006629;regulation of leukocyte cell-cell adhesion#GO:1903037;negative regulation of cellular process#GO:0048523;negative regulation of cell activation#GO:0050866;negative regulation of multicellular organismal process#GO:0051241;primary metabolic process#GO:0044238;negative regulation of leukocyte cell-cell adhesion#GO:1903038;phospholipid metabolic process#GO:0006644;phosphatidylglycerol metabolic process#GO:0046471;regulation of T cell proliferation#GO:0042129;regulation of immune system process#GO:0002682;regulation of cell-cell adhesion#GO:0022407;regulation of cellular process#GO:0050794;negative regulation of T cell activation#GO:0050868;regulation of cell population proliferation#GO:0042127 phospholipase#PC00186 HUMAN|HGNC=23088|UniProtKB=Q0GE19 Q0GE19 SLC10A7 PTHR18640:SF5 SOLUTE CARRIER FAMILY 10 MEMBER 7 SODIUM_BILE ACID COTRANSPORTER 7 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 secondary carrier transporter#PC00258;transporter#PC00227 HUMAN|HGNC=11323|UniProtKB=P43307 P43307 SSR1 PTHR12924:SF0 TRANSLOCON-ASSOCIATED PROTEIN, ALPHA SUBUNIT TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT ALPHA membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 membrane traffic protein#PC00150 HUMAN|HGNC=13075|UniProtKB=Q9Y2X9 Q9Y2X9 ZNF281 PTHR24388:SF112 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 281-RELATED RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=29851|UniProtKB=Q86UW6 Q86UW6 N4BP2 PTHR46535:SF1 NEDD4-BINDING PROTEIN 2 NEDD4-BINDING PROTEIN 2 nuclease activity#GO:0004518;endonuclease activity#GO:0004519;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 HUMAN|HGNC=15283|UniProtKB=Q8NGK9 Q8NGK9 OR5D16 PTHR48018:SF3 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5D16 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cellular process#GO:0009987;signal transduction#GO:0007165;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;sensory perception of smell#GO:0007608;response to stimulus#GO:0050896;signaling#GO:0023052;G protein-coupled receptor signaling pathway#GO:0007186;nervous system process#GO:0050877;sensory perception#GO:0007600;cell communication#GO:0007154 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=8347|UniProtKB=Q13606 Q13606 OR5I1 PTHR48018:SF76 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5I1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;signal transduction#GO:0007165;cellular process#GO:0009987;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;sensory perception#GO:0007600;nervous system process#GO:0050877;cell communication#GO:0007154;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;sensory perception of smell#GO:0007608;signaling#GO:0023052 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=18589|UniProtKB=Q9BZE7 Q9BZE7 C22orf23 PTHR28348:SF1 UPF0193 PROTEIN EVG1 UPF0193 PROTEIN EVG1 HUMAN|HGNC=29327|UniProtKB=Q5VZ46 Q5VZ46 KIAA1614 PTHR14102:SF12 PAR-6-RELATED CDNA SEQUENCE BC034090 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 microtubule organizing center organization#GO:0031023;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;cell-cell junction maintenance#GO:0045217;microtubule cytoskeleton organization#GO:0000226;cell-cell junction organization#GO:0045216;establishment or maintenance of cell polarity#GO:0007163;cytoskeleton organization#GO:0007010;cell junction organization#GO:0034330;centrosome cycle#GO:0007098;cell cycle process#GO:0022402;cellular process#GO:0009987;cell cycle#GO:0007049;organelle organization#GO:0006996;cellular component organization#GO:0016043 membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell cortex#GO:0005938;apical plasma membrane#GO:0016324;protein kinase complex#GO:1902911;apical part of cell#GO:0045177;transferase complex#GO:1990234;plasma membrane#GO:0005886;cytoplasm#GO:0005737;plasma membrane region#GO:0098590;protein-containing complex#GO:0032991;nucleus#GO:0005634;cell periphery#GO:0071944;membrane#GO:0016020 cell junction protein#PC00070;tight junction#PC00214 HUMAN|HGNC=31666|UniProtKB=Q6DHV5 Q6DHV5 CC2D2B PTHR20837:SF2 CENTROSOMAL PROTEIN-RELATED PROTEIN CC2D2B non-motile cilium assembly#GO:1905515;localization#GO:0051179;cilium organization#GO:0044782;organelle assembly#GO:0070925;protein localization to organelle#GO:0033365;cell projection organization#GO:0030030;protein localization to cilium#GO:0061512;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cellular component organization or biogenesis#GO:0071840;intracellular protein localization#GO:0008104;plasma membrane bounded cell projection assembly#GO:0120031;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;macromolecule localization#GO:0033036;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cell projection assembly#GO:0030031 plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cilium#GO:0005929;ciliary transition zone#GO:0035869 HUMAN|HGNC=55126|UniProtKB=X6R8D5 X6R8D5 CIMIP3 PTHR35444:SF1 RIKEN CDNA 1700001C19 GENE CILIARY MICROTUBULE INNER PROTEIN 3 HUMAN|HGNC=19832|UniProtKB=Q86T13 Q86T13 CLEC14A PTHR14789:SF5 CHONDROLECTIN VARIANT CHODLFDELTAE. C-TYPE LECTIN DOMAIN FAMILY 14 MEMBER A binding#GO:0005488;protein binding#GO:0005515;extracellular matrix binding#GO:0050840 cellular process#GO:0009987;cell migration#GO:0016477;cell motility#GO:0048870 side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;plasma membrane#GO:0005886;membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944 HUMAN|HGNC=9387|UniProtKB=Q9UGI9 Q9UGI9 PRKAG3 PTHR13780:SF31 AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-3 nucleoside phosphate binding#GO:1901265;binding#GO:0005488;kinase binding#GO:0019900;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;protein binding#GO:0005515;enzyme regulator activity#GO:0030234;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;ribonucleotide binding#GO:0032553;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;kinase regulator activity#GO:0019207;protein kinase regulator activity#GO:0019887;ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;cation binding#GO:0043169;molecular function regulator activity#GO:0098772;nucleotide binding#GO:0000166 regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;response to nutrient levels#GO:0031667;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;response to stress#GO:0006950;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;cellular response to glucose starvation#GO:0042149;regulation of biosynthetic process#GO:0009889;regulation of catabolic process#GO:0009894;cellular response to starvation#GO:0009267;regulation of carbohydrate metabolic process#GO:0006109;cellular response to nutrient levels#GO:0031669;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of carbohydrate biosynthetic process#GO:0043255;response to starvation#GO:0042594;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;cellular response to stress#GO:0033554 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;protein kinase complex#GO:1902911;membrane-bounded organelle#GO:0043227;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle#GO:0043229;transferase complex#GO:1990234;catalytic complex#GO:1902494 kinase modulator#PC00140 HUMAN|HGNC=30512|UniProtKB=Q5JSH3 Q5JSH3 WDR44 PTHR14221:SF72 WD REPEAT DOMAIN 44 WD REPEAT-CONTAINING PROTEIN 44 cilium organization#GO:0044782;organelle assembly#GO:0070925;regulation of cellular process#GO:0050794;cell projection organization#GO:0030030;cilium assembly#GO:0060271;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;cellular component organization or biogenesis#GO:0071840;regulation of transport#GO:0051049;regulation of localization#GO:0032879;plasma membrane bounded cell projection assembly#GO:0120031;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cell projection assembly#GO:0030031 bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;Golgi apparatus#GO:0005794;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;vesicle membrane#GO:0012506;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768;endosome membrane#GO:0010008;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982 HUMAN|HGNC=3817|UniProtKB=Q12952 Q12952 FOXL1 PTHR11829:SF204 FORKHEAD BOX PROTEIN FORKHEAD BOX PROTEIN L1 cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;developmental process#GO:0032502;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;winged helix/forkhead transcription factor#PC00246;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=4550|UniProtKB=Q13227 Q13227 GPS2 PTHR22654:SF2 G PROTEIN PATHWAY SUPPRESSOR 2 G PROTEIN PATHWAY SUPPRESSOR 2 transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667 protein-binding activity modulator#PC00095 HUMAN|HGNC=25407|UniProtKB=Q96QD9 Q96QD9 FYTTD1 PTHR21038:SF2 40-2-3 PROTEIN-RELATED UAP56-INTERACTING FACTOR protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;protein-RNA adaptor activity#GO:0140517 biosynthetic process#GO:0009058;gene expression#GO:0010467;establishment of localization in cell#GO:0051649;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule localization#GO:0033036;nitrogen compound transport#GO:0071705;macromolecule metabolic process#GO:0043170;establishment of localization#GO:0051234;transport#GO:0006810;metabolic process#GO:0008152;RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907;mRNA transport#GO:0051028;establishment of RNA localization#GO:0051236;nucleobase-containing compound transport#GO:0015931;RNA transport#GO:0050658;RNA localization#GO:0006403;nuclear transport#GO:0051169;nuclear export#GO:0051168;localization#GO:0051179;mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;nucleic acid transport#GO:0050657;nucleocytoplasmic transport#GO:0006913 organelle lumen#GO:0043233;nuclear speck#GO:0016607;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;intracellular membraneless organelle#GO:0043232;nuclear body#GO:0016604;membraneless organelle#GO:0043228 HUMAN|HGNC=28873|UniProtKB=Q7Z7D3 Q7Z7D3 VTCN1 PTHR24100:SF0 BUTYROPHILIN V-SET DOMAIN-CONTAINING T-CELL ACTIVATION INHIBITOR 1 protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488 immune response-activating signaling pathway#GO:0002757;cell surface receptor signaling pathway#GO:0007166;antigen receptor-mediated signaling pathway#GO:0050851;regulation of multicellular organismal process#GO:0051239;positive regulation of immune system process#GO:0002684;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;signal transduction#GO:0007165;cellular process#GO:0009987;immune system process#GO:0002376;response to stimulus#GO:0050896;signaling#GO:0023052;regulation of biological process#GO:0050789;immune response-regulating signaling pathway#GO:0002764;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;T cell receptor signaling pathway#GO:0050852;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;positive regulation of response to stimulus#GO:0048584;immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007;regulation of cytokine production#GO:0001817;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;cell communication#GO:0007154;regulation of immune response#GO:0050776;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;immune response-activating cell surface receptor signaling pathway#GO:0002429;cellular response to stimulus#GO:0051716 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell surface#GO:0009986;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;membrane#GO:0016020 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=21747|UniProtKB=Q17RY0 Q17RY0 CPEB4 PTHR12566:SF2 CYTOPLASMIC POLYADENYLATION ELEMENT BINDING PROTEIN CPEB CYTOPLASMIC POLYADENYLATION ELEMENT-BINDING PROTEIN 4 translation factor activity#GO:0180051;mRNA 3'-UTR binding#GO:0003730;translation regulator activity#GO:0045182;mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;ribonucleoprotein complex binding#GO:0043021;ribosome binding#GO:0043022;protein-containing complex binding#GO:0044877 biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of protein metabolic process#GO:0051246;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;negative regulation of translation#GO:0017148 nucleus#GO:0005634;neuron projection#GO:0043005;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cell junction#GO:0030054 mRNA polyadenylation factor#PC00146 HUMAN|HGNC=9609|UniProtKB=P49190 P49190 PTH2R PTHR45620:SF7 PDF RECEPTOR-LIKE PROTEIN-RELATED PARATHYROID HORMONE 2 RECEPTOR transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=23844|UniProtKB=A6QL63 A6QL63 ABTB3 PTHR46071:SF1 ANKYRIN REPEAT AND BTB/POZ DOMAIN-CONTAINING ANKYRIN REPEAT- AND BTB_POZ DOMAIN-CONTAINING PROTEIN 3 scaffold/adaptor protein#PC00226 HUMAN|HGNC=25408|UniProtKB=Q9BQI6 Q9BQI6 SLF1 PTHR46677:SF1 SMC5-SMC6 COMPLEX LOCALIZATION FACTOR PROTEIN 1 SMC5-SMC6 COMPLEX LOCALIZATION FACTOR PROTEIN 1 protein localization to organelle#GO:0033365;response to stimulus#GO:0050896;response to stress#GO:0006950;macromolecule localization#GO:0033036;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;localization#GO:0051179;intracellular protein localization#GO:0008104;DNA damage response#GO:0006974;cellular response to stress#GO:0033554 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694;site of double-strand break#GO:0035861;nucleus#GO:0005634;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;site of DNA damage#GO:0090734;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HUMAN|HGNC=8790|UniProtKB=Q13956 Q13956 PDE6H PTHR12122:SF5 RETINAL CONE RHODOPSIN-SENSITIVE CGMP 3',5'-CYCLIC PHOSPHODIESTERASE GAMMA-SUBUNIT-RELATED RETINAL CONE RHODOPSIN-SENSITIVE CGMP 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT GAMMA positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of cell communication#GO:0010646;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789;regulation of ERBB signaling pathway#GO:1901184;regulation of G protein-coupled receptor signaling pathway#GO:0008277;regulation of response to stimulus#GO:0048583;positive regulation of response to stimulus#GO:0048584;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of epidermal growth factor receptor signaling pathway#GO:0042058;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518 cilium#GO:0005929;cell projection membrane#GO:0031253;membrane-bounded organelle#GO:0043227;non-motile cilium#GO:0097730;photoreceptor outer segment#GO:0001750;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;9+0 non-motile cilium#GO:0097731;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;photoreceptor cell cilium#GO:0097733;plasma membrane region#GO:0098590;plasma membrane#GO:0005886;ciliary membrane#GO:0060170 phosphodiesterase#PC00185 HUMAN|HGNC=13507|UniProtKB=Q96PQ6 Q96PQ6 ZNF317 PTHR24377:SF22 IP01015P-RELATED ZINC FINGER PROTEIN 317 RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=12631|UniProtKB=P40818 P40818 USP8 PTHR21646:SF27 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 8 deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;cysteine-type deubiquitinase activity#GO:0004843;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783 positive regulation of cellular process#GO:0048522;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;regulation of signal transduction#GO:0009966;regulation of response to stimulus#GO:0048583;positive regulation of canonical Wnt signaling pathway#GO:0090263;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of cell communication#GO:0010646;Ras protein signal transduction#GO:0007265;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;organelle organization#GO:0006996;regulation of canonical Wnt signaling pathway#GO:0060828;regulation of protein stability#GO:0031647;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of Wnt signaling pathway#GO:0030177;endomembrane system organization#GO:0010256;intracellular signaling cassette#GO:0141124;cellular component organization or biogenesis#GO:0071840;vesicle organization#GO:0016050;endosome organization#GO:0007032;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signaling#GO:0023052;regulation of Wnt signaling pathway#GO:0030111;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;regulation of biological quality#GO:0065008 cell junction#GO:0030054;intracellular anatomical structure#GO:0005622;postsynaptic density#GO:0014069;synapse#GO:0045202;neuron to neuron synapse#GO:0098984;cellular anatomical structure#GO:0110165;postsynaptic specialization#GO:0099572;asymmetric synapse#GO:0032279;organelle#GO:0043226;cytoplasm#GO:0005737;postsynapse#GO:0098794;midbody#GO:0030496;cytosol#GO:0005829 cysteine protease#PC00081 HUMAN|HGNC=21057|UniProtKB=Q9H1X1 Q9H1X1 RSPH9 PTHR22069:SF0 MITOCHONDRIAL RIBOSOMAL PROTEIN S18 RADIAL SPOKE HEAD PROTEIN 9 HOMOLOG cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection organization#GO:0120036;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;plasma membrane bounded cell projection assembly#GO:0120031;cell projection organization#GO:0030030;cilium assembly#GO:0060271;cellular component organization#GO:0016043;microtubule cytoskeleton organization#GO:0000226;axoneme assembly#GO:0035082;cilium organization#GO:0044782;organelle assembly#GO:0070925;microtubule bundle formation#GO:0001578 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;axoneme#GO:0005930;cilium#GO:0005929;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;ciliary plasm#GO:0097014;organelle#GO:0043226 ribosomal protein#PC00202 HUMAN|HGNC=10665|UniProtKB=Q9BVJ6 Q9BVJ6 UTP14A PTHR14150:SF14 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14 HOMOLOG A enzyme activator activity#GO:0008047;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234 metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613 nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;small-subunit processome#GO:0032040;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;intracellular organelle#GO:0043229;preribosome#GO:0030684;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;nucleolus#GO:0005730;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 RNA metabolism protein#PC00031 HUMAN|HGNC=16839|UniProtKB=Q5TEJ8 Q5TEJ8 THEMIS2 PTHR15215:SF2 CABIT DOMAIN-CONTAINING PROTEIN PROTEIN THEMIS2 regulation of immune response#GO:0050776;immune system process#GO:0002376;cell communication#GO:0007154;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;immune response-regulating signaling pathway#GO:0002764;signaling#GO:0023052;immune response-activating cell surface receptor signaling pathway#GO:0002429;response to stimulus#GO:0050896;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166;T cell receptor signaling pathway#GO:0050852;immune response-activating signaling pathway#GO:0002757;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;cellular process#GO:0009987;positive regulation of immune system process#GO:0002684;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;positive regulation of response to stimulus#GO:0048584;antigen receptor-mediated signaling pathway#GO:0050851 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=13404|UniProtKB=Q9P2E7 Q9P2E7 PCDH10 PTHR24028:SF0 CADHERIN-87A PROTOCADHERIN-10 cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 cadherin#PC00057;cell adhesion molecule#PC00069 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HUMAN|HGNC=5286|UniProtKB=P08908 P08908 HTR1A PTHR24247:SF20 5-HYDROXYTRYPTAMINE RECEPTOR 5-HYDROXYTRYPTAMINE RECEPTOR 1A molecular transducer activity#GO:0060089;cation binding#GO:0043169;serotonin binding#GO:0051378;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888;heterocyclic compound binding#GO:1901363;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;neurotransmitter receptor activity#GO:0030594;G protein-coupled amine receptor activity#GO:0008227 synaptic signaling#GO:0099536;cellular process#GO:0009987;signal transduction#GO:0007165;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway#GO:0007193;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;chemical synaptic transmission#GO:0007268;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;anterograde trans-synaptic signaling#GO:0098916;signaling#GO:0023052;trans-synaptic signaling#GO:0099537;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;dendrite#GO:0030425;dendritic tree#GO:0097447 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;5HT1 type receptor mediated signaling pathway#P04373>5HT1 Receptor#P04404;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GsPCR#P00720 HUMAN|HGNC=29825|UniProtKB=Q9BUA6 Q9BUA6 MYL10 PTHR23049:SF36 MYOSIN REGULATORY LIGHT CHAIN 2 MYOSIN REGULATORY LIGHT CHAIN 10 myosin binding#GO:0017022;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;metal ion binding#GO:0046872;cation binding#GO:0043169;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;calcium ion binding#GO:0005509 mitochondrion#GO:0005739;myosin complex#GO:0016459;actin cytoskeleton#GO:0015629;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=22981|UniProtKB=Q5PT55 Q5PT55 SLC10A5 PTHR10361:SF29 SODIUM-BILE ACID COTRANSPORTER SODIUM_BILE ACID COTRANSPORTER 5 symporter activity#GO:0015293;carboxylic acid transmembrane transporter activity#GO:0046943;bile acid transmembrane transporter activity#GO:0015125;monoatomic cation transmembrane transporter activity#GO:0008324;solute:sodium symporter activity#GO:0015370;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;active transmembrane transporter activity#GO:0022804;solute:monoatomic cation symporter activity#GO:0015294;monoatomic ion transmembrane transporter activity#GO:0015075 lipid localization#GO:0010876;bile acid and bile salt transport#GO:0015721;transport#GO:0006810;organic acid transport#GO:0015849;carboxylic acid transport#GO:0046942;localization#GO:0051179;establishment of localization#GO:0051234;organic hydroxy compound transport#GO:0015850;monocarboxylic acid transport#GO:0015718;macromolecule localization#GO:0033036;lipid transport#GO:0006869 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 primary active transporter#PC00068 HUMAN|HGNC=17726|UniProtKB=Q8WWF5 Q8WWF5 ZNRF4 PTHR22765:SF347 RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING E3 UBIQUITIN-PROTEIN LIGASE ZNRF4 transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659 protein metabolic process#GO:0019538;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;regulation of cell cycle#GO:0051726;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;modification-dependent protein catabolic process#GO:0019941;regulation of biological process#GO:0050789;primary metabolic process#GO:0044238;negative regulation of biological process#GO:0048519;ubiquitin-dependent protein catabolic process#GO:0006511;negative regulation of cell cycle#GO:0045786;macromolecule metabolic process#GO:0043170;negative regulation of cellular process#GO:0048523;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;biological regulation#GO:0065007;cellular process#GO:0009987 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=33342|UniProtKB=Q6PDA7 Q6PDA7 SPAG11A PTHR14081:SF3 SPERM-ASSOCIATED ANTIGEN 11A-RELATED-RELATED SPERM-ASSOCIATED ANTIGEN 11A-RELATED HUMAN|HGNC=21084|UniProtKB=Q9P2D6 Q9P2D6 FAM135A PTHR12482:SF40 LIPASE ROG1-RELATED-RELATED PROTEIN FAM135A hydrolase activity#GO:0016787;lipase activity#GO:0016298;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788 cellular process#GO:0009987;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;primary metabolic process#GO:0044238 HUMAN|HGNC=12875|UniProtKB=Q9NZV7 Q9NZV7 ZIM2 PTHR24384:SF256 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED ZINC FINGER IMPRINTED 2 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA-binding transcription factor#PC00218 HUMAN|HGNC=24750|UniProtKB=Q32M78 Q32M78 ZNF699 PTHR24377:SF899 IP01015P-RELATED ZINC FINGER PROTEIN 699 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=6221|UniProtKB=P22001 P22001 KCNA3 PTHR11537:SF28 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 3 transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261;potassium channel activity#GO:0005267;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;transporter activity#GO:0005215;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832 cellular process#GO:0009987;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813;transport#GO:0006810;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;action potential#GO:0001508;metal ion transport#GO:0030001;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085 membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;cation channel complex#GO:0034703;voltage-gated potassium channel complex#GO:0008076;transporter complex#GO:1990351;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;axon#GO:0030424;transmembrane transporter complex#GO:1902495 ion channel#PC00133;voltage-gated ion channel#PC00241 HUMAN|HGNC=13659|UniProtKB=Q9HAZ1 Q9HAZ1 CLK4 PTHR45646:SF1 SERINE/THREONINE-PROTEIN KINASE DOA-RELATED DUAL SPECIFICITY PROTEIN KINASE CLK4 catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=18996|UniProtKB=Q8IV63 Q8IV63 VRK3 PTHR11909:SF99 CASEIN KINASE-RELATED SERINE_THREONINE-PROTEIN KINASE VRK3 kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 cell communication#GO:0007154;DNA damage response#GO:0006974;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;response to stress#GO:0006950;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=2023|UniProtKB=P51795 P51795 CLCN5 PTHR45711:SF7 CHLORIDE CHANNEL PROTEIN H(+)_CL(-) EXCHANGE TRANSPORTER 5 monoatomic anion transmembrane transporter activity#GO:0008509;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;chloride channel activity#GO:0005254;chloride transmembrane transporter activity#GO:0015108;passive transmembrane transporter activity#GO:0022803;voltage-gated monoatomic anion channel activity#GO:0008308;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;channel activity#GO:0015267;voltage-gated channel activity#GO:0022832;monoatomic anion channel activity#GO:0005253 monoatomic anion transmembrane transport#GO:0098656;multicellular organismal process#GO:0032501;monoatomic ion transmembrane transport#GO:0034220;monoatomic anion transport#GO:0006820;cellular process#GO:0009987;renal system process#GO:0003014;chloride transmembrane transport#GO:1902476;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;system process#GO:0003008;inorganic anion transport#GO:0015698;monoatomic ion transport#GO:0006811;chloride transport#GO:0006821;transport#GO:0006810 vesicle membrane#GO:0012506;membrane#GO:0016020;cell periphery#GO:0071944;lysosomal membrane#GO:0005765;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;vacuole#GO:0005773;plasma membrane#GO:0005886;cytoplasm#GO:0005737;Golgi apparatus#GO:0005794;lytic vacuole#GO:0000323;vacuolar membrane#GO:0005774;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular vesicle#GO:0097708;lytic vacuole membrane#GO:0098852;vesicle#GO:0031982;lysosome#GO:0005764;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;endosome#GO:0005768;endosome membrane#GO:0010008;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410 transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=26827|UniProtKB=Q2QL34 Q2QL34 MPV17L PTHR11266:SF39 PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17 MPV17-LIKE PROTEIN regulation of localization#GO:0032879;regulation of transport#GO:0051049;negative regulation of cellular process#GO:0048523;regulation of apoptotic process#GO:0042981;regulation of response to stimulus#GO:0048583;negative regulation of response to stimulus#GO:0048585;negative regulation of apoptotic process#GO:0043066;regulation of membrane permeability#GO:0090559;negative regulation of signal transduction#GO:0009968;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of mitochondrial membrane permeability#GO:0046902;negative regulation of programmed cell death#GO:0043069;negative regulation of cell communication#GO:0010648;regulation of biological quality#GO:0065008;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;regulation of apoptotic signaling pathway#GO:2001233;negative regulation of apoptotic signaling pathway#GO:2001234;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of cell communication#GO:0010646;negative regulation of cellular component organization#GO:0051129;negative regulation of organelle organization#GO:0010639;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;regulation of organelle organization#GO:0033043;regulation of mitochondrion organization#GO:0010821;regulation of biological process#GO:0050789 mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 transporter#PC00227 HUMAN|HGNC=5951|UniProtKB=Q9BY67 Q9BY67 CADM1 PTHR45889:SF2 IG-LIKE DOMAIN-CONTAINING PROTEIN CELL ADHESION MOLECULE 1 signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515 regulation of response to external stimulus#GO:0032101;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;cell-cell adhesion#GO:0098609;positive regulation of immune system process#GO:0002684;positive regulation of response to external stimulus#GO:0032103;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;regulation of cell killing#GO:0031341;cell adhesion#GO:0007155;regulation of lymphocyte mediated immunity#GO:0002706;positive regulation of immune effector process#GO:0002699;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;regulation of natural killer cell mediated cytotoxicity#GO:0042269;positive regulation of innate immune response#GO:0045089;positive regulation of cellular process#GO:0048522;positive regulation of natural killer cell mediated cytotoxicity#GO:0045954;homophilic cell-cell adhesion#GO:0007156;detection of stimulus#GO:0051606;positive regulation of response to biotic stimulus#GO:0002833;regulation of innate immune response#GO:0045088;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;positive regulation of defense response#GO:0031349;regulation of response to stress#GO:0080134;positive regulation of leukocyte mediated immunity#GO:0002705;positive regulation of natural killer cell mediated immunity#GO:0002717;regulation of response to biotic stimulus#GO:0002831;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of natural killer cell mediated immunity#GO:0002715;regulation of leukocyte mediated immunity#GO:0002703;regulation of leukocyte mediated cytotoxicity#GO:0001910;regulation of immune effector process#GO:0002697;positive regulation of lymphocyte mediated immunity#GO:0002708;regulation of defense response#GO:0031347;cell recognition#GO:0008037;regulation of immune response#GO:0050776 cell junction#GO:0030054;cellular anatomical structure#GO:0110165;synapse#GO:0045202;plasma membrane#GO:0005886;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944 HUMAN|HGNC=21495|UniProtKB=Q96FN5 Q96FN5 KIF12 PTHR24115:SF418 KINESIN-RELATED KINESIN-LIKE PROTEIN KIF12 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;ATP-dependent activity#GO:0140657;protein binding#GO:0005515;hydrolase activity, acting on acid anhydrides#GO:0016817;cytoskeletal protein binding#GO:0008092;cytoskeletal motor activity#GO:0003774;polypeptide conformation or assembly isomerase activity#GO:0120544;microtubule binding#GO:0008017;hydrolase activity#GO:0016787;microtubule motor activity#GO:0003777;ATP hydrolysis activity#GO:0016887;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;macromolecular conformation isomerase activity#GO:0120543;tubulin binding#GO:0015631;isomerase activity#GO:0016853;ribonucleoside triphosphate phosphatase activity#GO:0017111 cellular process#GO:0009987;microtubule-based process#GO:0007017;microtubule-based movement#GO:0007018 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;microtubule#GO:0005874;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;microtubule associated complex#GO:0005875;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;supramolecular complex#GO:0099080;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cytoskeleton#GO:0005856 microtubule or microtubule-binding cytoskeletal protein#PC00157;microtubule binding motor protein#PC00156 HUMAN|HGNC=37287|UniProtKB=P0CV99 P0CV99 TSPY4 PTHR11875:SF12 TESTIS-SPECIFIC Y-ENCODED PROTEIN TESTIS-SPECIFIC Y-ENCODED PROTEIN 1-RELATED histone binding#GO:0042393;chromatin binding#GO:0003682;binding#GO:0005488;protein binding#GO:0005515 chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=29189|UniProtKB=Q9UPR6 Q9UPR6 ZFR2 PTHR45762:SF2 ZINC FINGER RNA-BINDING PROTEIN ZINC FINGER RNA-BINDING PROTEIN 2 binding#GO:0005488;nucleic acid binding#GO:0003676;double-stranded RNA binding#GO:0003725;RNA binding#GO:0003723;single-stranded RNA binding#GO:0003727 RNA metabolism protein#PC00031 HUMAN|HGNC=9440|UniProtKB=O43422 O43422 THAP12 PTHR46289:SF16 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED 52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE HUMAN|HGNC=13248|UniProtKB=Q9BXU9 Q9BXU9 CALN1 PTHR46311:SF3 CALCIUM-BINDING PROTEIN 8-RELATED CALCIUM-BINDING PROTEIN 8 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;trans-Golgi network membrane#GO:0032588;organelle#GO:0043226;trans-Golgi network#GO:0005802;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=11454|UniProtKB=P50226 P50226 SULT1A2 PTHR11783:SF324 SULFOTRANSFERASE SULT SULFOTRANSFERASE 1A2 catalytic activity#GO:0003824;transferase activity#GO:0016740;sulfotransferase activity#GO:0008146;transferase activity, transferring sulphur-containing groups#GO:0016782 cellular process#GO:0009987;metabolic process#GO:0008152;sulfur compound metabolic process#GO:0006790 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 transferase#PC00220;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=20248|UniProtKB=Q8IYK8 Q8IYK8 REM2 PTHR45775:SF5 RAD, GEM/KIR FAMILY MEMBER 2, ISOFORM C GTP-BINDING PROTEIN REM 2 ion channel regulator activity#GO:0099106;molecular function regulator activity#GO:0098772;nucleotide binding#GO:0000166;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;transporter regulator activity#GO:0141108;channel regulator activity#GO:0016247;calcium channel regulator activity#GO:0005246;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;ribonucleotide binding#GO:0032553;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;guanyl nucleotide binding#GO:0019001;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HUMAN|HGNC=23752|UniProtKB=Q8IU89 Q8IU89 CERS3 PTHR12560:SF18 LONGEVITY ASSURANCE FACTOR 1 LAG1 CERAMIDE SYNTHASE 3 catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;cellular process#GO:0009987;primary metabolic process#GO:0044238;ceramide metabolic process#GO:0006672;lipid metabolic process#GO:0006629;ceramide biosynthetic process#GO:0046513;sphingolipid biosynthetic process#GO:0030148;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 transferase#PC00220;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=20900|UniProtKB=Q9UJA5 Q9UJA5 TRMT6 PTHR12945:SF0 TRANSLATION INITIATION FACTOR EIF3-RELATED TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT TRM6 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;transferase complex#GO:1990234;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;methyltransferase complex#GO:0034708;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 translation initiation factor#PC00224 HUMAN|HGNC=25415|UniProtKB=Q8N3J5 Q8N3J5 PPM1K PTHR47992:SF274 PROTEIN PHOSPHATASE PROTEIN PHOSPHATASE MN(2+)-DEPENDENT 1K protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096 regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;regulation of biological process#GO:0050789;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HUMAN|HGNC=4606|UniProtKB=P30101 P30101 PDIA3 PTHR18929:SF257 PROTEIN DISULFIDE ISOMERASE PROTEIN DISULFIDE-ISOMERASE A3 catalytic activity, acting on a protein#GO:0140096;intramolecular oxidoreductase activity#GO:0016860;isomerase activity#GO:0016853;catalytic activity#GO:0003824;protein disulfide isomerase activity#GO:0003756 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;response to stress#GO:0006950;protein folding#GO:0006457;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;response to endoplasmic reticulum stress#GO:0034976;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;cell surface#GO:0009986;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 chaperone#PC00072 HUMAN|HGNC=30760|UniProtKB=Q9HC07 Q9HC07 TMEM165 PTHR12608:SF1 TRANSMEMBRANE PROTEIN HTP-1 RELATED DIVALENT CATION_PROTON ANTIPORTER TMEM165-RELATED monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation transmembrane transporter activity#GO:0008324;metal ion transmembrane transporter activity#GO:0046873;calcium ion transmembrane transporter activity#GO:0015085;transition metal ion transmembrane transporter activity#GO:0046915;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801;calcium ion transport#GO:0006816;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;establishment of localization#GO:0051234;intracellular monoatomic cation homeostasis#GO:0030003;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;metal ion transport#GO:0030001;homeostatic process#GO:0042592;calcium ion transmembrane transport#GO:0070588;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;transition metal ion transport#GO:0000041;inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794 HUMAN|HGNC=10058|UniProtKB=Q9UBS8 Q9UBS8 RNF14 PTHR11685:SF290 RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING E3 UBIQUITIN-PROTEIN LIGASE RNF14 enzyme binding#GO:0019899;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;binding#GO:0005488;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;protein binding#GO:0005515;catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;catabolic process#GO:0009056;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;catalytic complex#GO:1902494;transferase complex#GO:1990234;ubiquitin ligase complex#GO:0000151;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=33902|UniProtKB=Q3LI83 Q3LI83 KRTAP24-1 PTHR23260:SF2 KERATIN ASSOCIATED PROTEIN 3-3-RELATED KERATIN-ASSOCIATED PROTEIN 24-1 structural protein#PC00211 HUMAN|HGNC=20362|UniProtKB=Q9Y4F5 Q9Y4F5 CEP170B PTHR15715:SF18 CENTROSOMAL PROTEIN OF 170 KDA CENTROSOMAL PROTEIN OF 170 KDA PROTEIN B protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 cytoskeleton organization#GO:0007010;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;microtubule anchoring at microtubule organizing center#GO:0072393;microtubule cytoskeleton organization#GO:0000226;microtubule anchoring#GO:0034453 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;centrosome#GO:0005813;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;centriole#GO:0005814;microtubule cytoskeleton#GO:0015630 scaffold/adaptor protein#PC00226 HUMAN|HGNC=6715|UniProtKB=Q14767 Q14767 LTBP2 PTHR24034:SF49 EGF-LIKE DOMAIN-CONTAINING PROTEIN LATENT-TRANSFORMING GROWTH FACTOR BETA-BINDING PROTEIN 2 binding#GO:0005488;extracellular matrix binding#GO:0050840 supramolecular fiber organization#GO:0097435;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043 extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cellular anatomical structure#GO:0110165 extracellular matrix structural protein#PC00103;extracellular matrix protein#PC00102 HUMAN|HGNC=6117|UniProtKB=P14316 P14316 IRF2 PTHR11949:SF22 INTERFERON REGULATORY FACTOR INTERFERON REGULATORY FACTOR 2 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 winged helix/forkhead transcription factor#PC00246;DNA-binding transcription factor#PC00218 HUMAN|HGNC=28373|UniProtKB=Q8TC90 Q8TC90 CCER1 PTHR37337:SF1 COILED-COIL DOMAIN-CONTAINING GLUTAMATE-RICH PROTEIN 1 COILED-COIL DOMAIN-CONTAINING GLUTAMATE-RICH PROTEIN 1 HUMAN|HGNC=38476|UniProtKB=B9A064 B9A064 IGLL5 PTHR23266:SF310 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN LAMBDA CONSTANT 1-RELATED antigen binding#GO:0003823;binding#GO:0005488 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449;immune effector process#GO:0002252;immune system process#GO:0002376;adaptive immune response#GO:0002250;response to stimulus#GO:0050896;immune response#GO:0006955 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=25953|UniProtKB=Q6N043 Q6N043 ZNF280D PTHR24388:SF34 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 280D sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=1587|UniProtKB=O95273 O95273 CCNDBP1 PTHR15492:SF4 CYCLIN D1-BINDING PROTEIN 1 CYCLIN-D1-BINDING PROTEIN 1 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=5887|UniProtKB=P01706 P01706 IGLV2-11 PTHR23267:SF501 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN LAMBDA VARIABLE 2-11 response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 protein-containing complex#GO:0032991 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=28354|UniProtKB=Q8IZ63 Q8IZ63 PRR22 PTHR37871:SF1 PROLINE-RICH PROTEIN 22 PROLINE-RICH PROTEIN 22 HUMAN|HGNC=37283|UniProtKB=Q6ZQQ2 Q6ZQQ2 SPATA31D1 PTHR21859:SF12 ACROSOME-SPECIFIC PROTEIN SPERMATOGENESIS-ASSOCIATED PROTEIN 31D1 HUMAN|HGNC=17903|UniProtKB=Q9NPJ6 Q9NPJ6 MED4 PTHR13208:SF2 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4 transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 core mediator complex#GO:0070847;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227 RNA metabolism protein#PC00031;general transcription factor#PC00259 HUMAN|HGNC=14349|UniProtKB=Q9P0V9 Q9P0V9 SEPTIN10 PTHR18884:SF50 SEPTIN SEPTIN-10 pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111 intracellular protein localization#GO:0008104;cytoskeleton-dependent cytokinesis#GO:0061640;localization#GO:0051179;cytokinesis#GO:0000910;cell division#GO:0051301;cell cycle process#GO:0022402;cellular process#GO:0009987;cell cycle#GO:0007049;macromolecule localization#GO:0033036 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;cell division site#GO:0032153;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;cell periphery#GO:0071944;cell cortex#GO:0005938 cytoskeletal protein#PC00085 HUMAN|HGNC=9337|UniProtKB=P04280 P04280 PRB1 PTHR23203:SF20 PROLINE-RICH PROTEIN BASIC SALIVARY PROLINE-RICH PROTEIN 1-RELATED antimicrobial response protein#PC00051 HUMAN|HGNC=9313|UniProtKB=Q16537 Q16537 PPP2R5E PTHR10257:SF80 SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT EPSILON ISOFORM enzyme activator activity#GO:0008047;phosphatase activator activity#GO:0019211;protein phosphatase regulator activity#GO:0019888;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;phosphatase regulator activity#GO:0019208 cellular process#GO:0009987;cell cycle process#GO:0022402;cell cycle#GO:0007049;organelle organization#GO:0006996;cellular component organization#GO:0016043;meiotic sister chromatid cohesion#GO:0051177;chromosome organization#GO:0051276;cellular component organization or biogenesis#GO:0071840;sister chromatid cohesion#GO:0007062 cytosol#GO:0005829;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;protein serine/threonine phosphatase complex#GO:0008287;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;protein phosphatase#PC00195 FGF signaling pathway#P00021>PP2A#P00629;Wnt signaling pathway#P00057>PP2A#P01438;EGF receptor signaling pathway#P00018>PP2A#P00547 HUMAN|HGNC=17229|UniProtKB=Q9UL16 Q9UL16 CFAP45 PTHR15504:SF1 NASOPHARYNGEAL EPITHELIUM SPECIFIC PROTEIN 1 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 45 biological regulation#GO:0065007;regulation of locomotion#GO:0040012;cellular process#GO:0009987;cilium movement involved in cell motility#GO:0060294;microtubule-based process#GO:0007017;flagellated sperm motility#GO:0030317;reproductive process#GO:0022414;regulation of microtubule-based movement#GO:0060632;regulation of cellular process#GO:0050794;microtubule-based movement#GO:0007018;cell motility#GO:0048870;regulation of biological process#GO:0050789;sperm motility#GO:0097722;regulation of biological quality#GO:0065008;regulation of cell motility#GO:2000145;cilium-dependent cell motility#GO:0060285;cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;regulation of microtubule-based process#GO:0032886 polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;sperm flagellum#GO:0036126;ciliary plasm#GO:0097014;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;axoneme#GO:0005930;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;supramolecular fiber#GO:0099512;intracellular organelle#GO:0043229;cilium#GO:0005929;9+2 motile cilium#GO:0097729;cellular anatomical structure#GO:0110165;axonemal microtubule#GO:0005879;organelle#GO:0043226;motile cilium#GO:0031514;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cytoplasmic microtubule#GO:0005881 HUMAN|HGNC=9446|UniProtKB=P16471 P16471 PRLR PTHR23036:SF86 CYTOKINE RECEPTOR PROLACTIN RECEPTOR cytokine receptor activity#GO:0004896;immune receptor activity#GO:0140375;cytokine binding#GO:0019955;signaling receptor activity#GO:0038023;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;protein binding#GO:0005515 cell surface receptor signaling pathway#GO:0007166;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of cellular process#GO:0048522;biological regulation#GO:0065007;response to cytokine#GO:0034097;response to chemical#GO:0042221;cytokine-mediated signaling pathway#GO:0019221;response to peptide#GO:1901652;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;positive regulation of cell population proliferation#GO:0008284;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;signaling receptor complex#GO:0043235 transmembrane signal receptor#PC00197 Gonadotropin-releasing hormone receptor pathway#P06664>PRLR#P06822 HUMAN|HGNC=6526|UniProtKB=P80188 P80188 LCN2 PTHR11430:SF13 LIPOCALIN NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 transfer/carrier protein#PC00219 HUMAN|HGNC=20315|UniProtKB=Q9H0Y0 Q9H0Y0 ATG10 PTHR14957:SF1 UBIQUITIN-LIKE-CONJUGATING ENZYME ATG10 UBIQUITIN-LIKE-CONJUGATING ENZYME ATG10 catalytic activity#GO:0003824;transferase activity#GO:0016740;Atg12 conjugating enzyme activity#GO:0061651;catalytic activity, acting on a protein#GO:0140096;Atg12 transferase activity#GO:0019777;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-like protein conjugating enzyme activity#GO:0061650 protein modification process#GO:0036211;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;protein modification by small protein conjugation#GO:0032446;catabolic process#GO:0009056;organelle assembly#GO:0070925;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;vacuole organization#GO:0007033;process utilizing autophagic mechanism#GO:0061919;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;autophagy#GO:0006914;cellular process#GO:0009987;autophagosome organization#GO:1905037;cellular component assembly#GO:0022607;macroautophagy#GO:0016236;post-translational protein modification#GO:0043687;metabolic process#GO:0008152;autophagy of mitochondrion#GO:0000422;cellular component organization or biogenesis#GO:0071840;mitophagy#GO:0000423;macromolecule metabolic process#GO:0043170;autophagosome assembly#GO:0000045 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=1442|UniProtKB=P0DP23 P0DP23 CALM1 PTHR23050:SF531 CALCIUM BINDING PROTEIN CALMODULIN-1 protein kinase activator activity#GO:0030295;enzyme activator activity#GO:0008047;protein serine/threonine kinase activator activity#GO:0043539;protein kinase regulator activity#GO:0019887;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;calcium ion binding#GO:0005509;small molecule binding#GO:0036094;binding#GO:0005488;kinase activator activity#GO:0019209;ion binding#GO:0043167;cation binding#GO:0043169;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;metal ion binding#GO:0046872 signaling#GO:0023052;response to stimulus#GO:0050896;detection of chemical stimulus#GO:0009593;regulation of biological process#GO:0050789;positive regulation of signaling#GO:0023056;response to calcium ion#GO:0051592;regulation of signaling#GO:0023051;intracellular signaling cassette#GO:0141124;response to chemical#GO:0042221;regulation of monoatomic ion transmembrane transport#GO:0034765;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;regulation of release of sequestered calcium ion into cytosol#GO:0051279;regulation of localization#GO:0032879;regulation of transport#GO:0051049;regulation of cell communication#GO:0010646;regulation of receptor signaling pathway via STAT#GO:1904892;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of metal ion transport#GO:0010959;cellular response to stimulus#GO:0051716;calcineurin-mediated signaling#GO:0097720;regulation of transmembrane transport#GO:0034762;positive regulation of signal transduction#GO:0009967;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;positive regulation of receptor signaling pathway via JAK-STAT#GO:0046427;regulation of calcium ion transport#GO:0051924;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of response to stimulus#GO:0048584;regulation of monoatomic ion transport#GO:0043269;positive regulation of cellular process#GO:0048522;detection of stimulus#GO:0051606;calcium-mediated signaling#GO:0019722;regulation of receptor signaling pathway via JAK-STAT#GO:0046425;regulation of response to stimulus#GO:0048583;response to metal ion#GO:0010038;regulation of monoatomic cation transmembrane transport#GO:1904062 organelle#GO:0043226;cellular anatomical structure#GO:0110165;myelin sheath#GO:0043209;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;microtubule cytoskeleton#GO:0015630;nucleus#GO:0005634;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;centrosome#GO:0005813;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 calmodulin-related#PC00061;calcium-binding protein#PC00060 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Calmodulin#P00755;B cell activation#P00010>Calmodulin#P00375;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Phosphorylase b kinase#P00716;T cell activation#P00053>Calmodulin#P01305;CCKR signaling map#P06959>CaM#P07193 HUMAN|HGNC=15768|UniProtKB=Q9NZT2 Q9NZT2 OGFR PTHR14015:SF1 OPIOID GROWTH FACTOR RECEPTOR OGFR ZETA-TYPE OPIOID RECEPTOR OPIOID GROWTH FACTOR RECEPTOR transmembrane signal receptor#PC00197 HUMAN|HGNC=34530|UniProtKB=A8MZ26 A8MZ26 EFCAB9 PTHR47065:SF1 EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 9 EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 9 molecular sensor activity#GO:0140299;molecular function regulator activity#GO:0098772 flagellated sperm motility#GO:0030317;spermatogenesis#GO:0007283;developmental process#GO:0032502;cell maturation#GO:0048469;cellular developmental process#GO:0048869;microtubule-based process#GO:0007017;cilium movement involved in cell motility#GO:0060294;cellular process#GO:0009987;developmental maturation#GO:0021700;male gamete generation#GO:0048232;sperm capacitation#GO:0048240;spermatid differentiation#GO:0048515;sexual reproduction#GO:0019953;cilium or flagellum-dependent cell motility#GO:0001539;cilium movement#GO:0003341;spermatid development#GO:0007286;cilium-dependent cell motility#GO:0060285;anatomical structure development#GO:0048856;multicellular organismal reproductive process#GO:0048609;developmental process involved in reproduction#GO:0003006;anatomical structure maturation#GO:0071695;sperm motility#GO:0097722;germ cell development#GO:0007281;cell differentiation#GO:0030154;gamete generation#GO:0007276;cell motility#GO:0048870;microtubule-based movement#GO:0007018;cellular process involved in reproduction in multicellular organism#GO:0022412;reproductive process#GO:0022414;cell development#GO:0048468 9+2 motile cilium#GO:0097729;cilium#GO:0005929;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;sperm principal piece#GO:0097228;cell projection#GO:0042995;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;motile cilium#GO:0031514;cellular anatomical structure#GO:0110165;sperm flagellum#GO:0036126 calcium-binding protein#PC00060;calmodulin-related#PC00061 HUMAN|HGNC=18257|UniProtKB=A6NER0 A6NER0 TBC1D3F PTHR22957:SF571 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN TBC1 DOMAIN FAMILY MEMBER 3-RELATED molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;enzyme activator activity#GO:0008047 G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HUMAN|HGNC=3180|UniProtKB=P24530 P24530 EDNRB PTHR46099:SF3 G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN ENDOTHELIN RECEPTOR TYPE B molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528 biological regulation#GO:0065007;blood circulation#GO:0008015;multicellular organismal process#GO:0032501;signal transduction#GO:0007165;developmental pigmentation#GO:0048066;cellular process#GO:0009987;system process#GO:0003008;regulation of anatomical structure size#GO:0090066;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;regulation of biological quality#GO:0065008;cell communication#GO:0007154;pigmentation#GO:0043473;G protein-coupled receptor signaling pathway#GO:0007186;circulatory system process#GO:0003013 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 Endothelin signaling pathway#P00019>ET-RA/B#P00580 HUMAN|HGNC=30279|UniProtKB=Q86X27 Q86X27 RALGPS2 PTHR23113:SF357 GUANINE NUCLEOTIDE EXCHANGE FACTOR RAS-SPECIFIC GUANINE NUCLEOTIDE-RELEASING FACTOR RALGPS2 guanyl-nucleotide exchange factor activity#GO:0005085;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 regulation of small GTPase mediated signal transduction#GO:0051056;regulation of response to stimulus#GO:0048583;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;small GTPase-mediated signal transduction#GO:0007264;cellular process#GO:0009987;signal transduction#GO:0007165;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of intracellular signal transduction#GO:1902531;Ras protein signal transduction#GO:0007265;regulation of signaling#GO:0023051;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of cell communication#GO:0010646;signaling#GO:0023052;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=24627|UniProtKB=Q96PD2 Q96PD2 DCBLD2 PTHR46806:SF3 F5/8 TYPE C DOMAIN-CONTAINING PROTEIN DISCOIDIN, CUB AND LCCL DOMAIN-CONTAINING PROTEIN 2 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 response to wounding#GO:0009611;response to stress#GO:0006950;response to stimulus#GO:0050896;wound healing#GO:0042060 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HUMAN|HGNC=2200|UniProtKB=P02458 P02458 COL2A1 PTHR24023:SF58 COLLAGEN ALPHA COLLAGEN ALPHA-1(II) CHAIN structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 cellular process#GO:0009987;skeletal system morphogenesis#GO:0048705;multicellular organismal process#GO:0032501;developmental process#GO:0032502;animal organ development#GO:0048513;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;animal organ morphogenesis#GO:0009887;extracellular structure organization#GO:0043062;animal gross anatomical part developmental process#GO:0160108;external encapsulating structure organization#GO:0045229;system development#GO:0048731;anatomical structure development#GO:0048856;extracellular matrix organization#GO:0030198;skeletal system development#GO:0001501 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;interstitial matrix#GO:0005614;supramolecular complex#GO:0099080;extracellular region#GO:0005576;extracellular protein-containing complex#GO:0140392 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 Integrin signalling pathway#P00034>Collagen#P00922 HUMAN|HGNC=1964|UniProtKB=P30926 P30926 CHRNB4 PTHR18945:SF385 NEUROTRANSMITTER GATED ION CHANNEL NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-4 monoatomic cation transmembrane transporter activity#GO:0008324;postsynaptic neurotransmitter receptor activity#GO:0098960;gated channel activity#GO:0022836;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;signaling receptor activity#GO:0038023;neurotransmitter receptor activity#GO:0030594;transporter activity#GO:0005215;molecular transducer activity#GO:0060089;channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation channel activity#GO:0005261;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857 response to chemical#GO:0042221;synaptic signaling#GO:0099536;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987;renal system process#GO:0003014;regulation of membrane potential#GO:0042391;calcium ion transport#GO:0006816;neuromuscular synaptic transmission#GO:0007274;response to stimulus#GO:0050896;signaling#GO:0023052;regulation of biological process#GO:0050789;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;cellular response to chemical stimulus#GO:0070887;response to oxygen-containing compound#GO:1901700;synaptic transmission, cholinergic#GO:0007271;acetylcholine receptor signaling pathway#GO:0095500;multicellular organismal process#GO:0032501;cellular response to nitrogen compound#GO:1901699;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;monoatomic ion transmembrane transport#GO:0034220;establishment of localization#GO:0051234;system process#GO:0003008;transport#GO:0006810;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;metal ion transport#GO:0030001;membrane depolarization#GO:0051899;chemical synaptic transmission#GO:0007268;cellular response to stimulus#GO:0051716;localization#GO:0051179;monoatomic cation transport#GO:0006812;cell communication#GO:0007154;response to nitrogen compound#GO:1901698;trans-synaptic signaling#GO:0099537 organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;postsynapse#GO:0098794;transmembrane transporter complex#GO:1902495;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;plasma membrane#GO:0005886;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020;cell junction#GO:0030054;transporter complex#GO:1990351;signaling receptor complex#GO:0043235;synaptic membrane#GO:0097060 ligand-gated ion channel#PC00141 Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086;Nicotine pharmacodynamics pathway#P06587>CHRNB4#P06610;Nicotinic acetylcholine receptor signaling pathway#P00044>beta#P01095 HUMAN|HGNC=1165|UniProtKB=Q9Y4D2 Q9Y4D2 DAGLA PTHR45792:SF13 DIACYLGLYCEROL LIPASE HOMOLOG-RELATED DIACYLGLYCEROL LIPASE-ALPHA triacylglycerol lipase activity#GO:0004806;lipase activity#GO:0016298;catalytic activity#GO:0003824;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787 cell communication#GO:0007154;anatomical structure development#GO:0048856;system development#GO:0048731;trans-synaptic signaling#GO:0099537;catabolic process#GO:0009056;primary metabolic process#GO:0044238;neutral lipid metabolic process#GO:0006638;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;acylglycerol metabolic process#GO:0006639;fatty acid metabolic process#GO:0006631;neutral lipid catabolic process#GO:0046461;developmental process#GO:0032502;lipid metabolic process#GO:0006629;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;oxoacid metabolic process#GO:0043436;glycerolipid catabolic process#GO:0046503;olefinic compound metabolic process#GO:0120254;animal gross anatomical part developmental process#GO:0160108;glycerolipid metabolic process#GO:0046486;cell differentiation#GO:0030154;small molecule metabolic process#GO:0044281;signaling#GO:0023052;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;regulation of biological process#GO:0050789;arachidonate metabolic process#GO:0019369;multicellular organism development#GO:0007275;acylglycerol catabolic process#GO:0046464;metabolic process#GO:0008152;unsaturated fatty acid metabolic process#GO:0033559;icosanoid metabolic process#GO:0006690;nervous system development#GO:0007399;long-chain fatty acid metabolic process#GO:0001676;synaptic signaling#GO:0099536;lipid catabolic process#GO:0016042;cellular process#GO:0009987 cell leading edge#GO:0031252;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;plasma membrane region#GO:0098590;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;synaptic membrane#GO:0097060;neuron projection membrane#GO:0032589;cell junction#GO:0030054;postsynapse#GO:0098794;cellular anatomical structure#GO:0110165;synapse#GO:0045202;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;postsynaptic membrane#GO:0045211;dendrite#GO:0030425;dendritic tree#GO:0097447;leading edge membrane#GO:0031256;cell projection membrane#GO:0031253 lipase#PC00143;metabolite interconversion enzyme#PC00262;hydrolase#PC00121 2-arachidonoylglycerol biosynthesis#P05726>DGL#P05736 HUMAN|HGNC=2183|UniProtKB=Q7Z7G8 Q7Z7G8 VPS13B PTHR12517:SF0 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 13B INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13B membrane traffic protein#PC00150 HUMAN|HGNC=3002|UniProtKB=P16444 P16444 DPEP1 PTHR10443:SF38 MICROSOMAL DIPEPTIDASE DIPEPTIDASE 1 peptidase activity#GO:0008233;hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 protease#PC00190;protein modifying enzyme#PC00260 HUMAN|HGNC=30694|UniProtKB=Q86SM8 Q86SM8 MRGPRE PTHR11334:SF26 MAS-RELATED G-PROTEIN COUPLED RECEPTOR MAS-RELATED G PROTEIN-COUPLED RECEPTOR MEMBER E molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=14131|UniProtKB=Q9P2W3 Q9P2W3 GNG13 PTHR15936:SF2 GUANINE NUCLEOTIDE-BINDING PROTEIN G I /G S /G O GAMMA-13 SUBUNIT GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)_G(S)_G(O) SUBUNIT GAMMA-13 binding#GO:0005488;protein binding#GO:0005515 signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 catalytic complex#GO:1902494;extrinsic component of cytoplasmic side of plasma membrane#GO:0031234;cytoplasmic side of membrane#GO:0098562;extrinsic component of membrane#GO:0019898;extrinsic component of plasma membrane#GO:0019897;side of membrane#GO:0098552;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane protein complex#GO:0098796;cytoplasmic side of plasma membrane#GO:0009898;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 protein-binding activity modulator#PC00095;G-protein#PC00020;heterotrimeric G-protein#PC00117 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Ggamma#P00751;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Ggamma#P00726;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Ggamma#P00721;Wnt signaling pathway#P00057>Ggamma#P01465 HUMAN|HGNC=30506|UniProtKB=Q8IVE3 Q8IVE3 PLEKHH2 PTHR22903:SF3 PLEKHH PROTEIN PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY H MEMBER 2 protein binding#GO:0005515;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779 negative regulation of cellular process#GO:0048523;regulation of actin filament-based process#GO:0032970;regulation of anatomical structure size#GO:0090066;regulation of protein depolymerization#GO:1901879;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;regulation of actin filament organization#GO:0110053;regulation of protein-containing complex disassembly#GO:0043244;negative regulation of protein depolymerization#GO:1901880;regulation of actin cytoskeleton organization#GO:0032956;biological regulation#GO:0065007;regulation of actin polymerization or depolymerization#GO:0008064;regulation of actin filament length#GO:0030832;negative regulation of actin filament depolymerization#GO:0030835;regulation of biological quality#GO:0065008;negative regulation of protein-containing complex disassembly#GO:0043242;negative regulation of cytoskeleton organization#GO:0051494;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of supramolecular fiber organization#GO:1902903;regulation of cellular component size#GO:0032535;negative regulation of cellular component organization#GO:0051129;cellular component organization#GO:0016043;negative regulation of organelle organization#GO:0010639;negative regulation of biological process#GO:0048519;regulation of actin filament depolymerization#GO:0030834;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;negative regulation of supramolecular fiber organization#GO:1902904;regulation of cytoskeleton organization#GO:0051493 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=9199|UniProtKB=P62875 P62875 POLR2L PTHR23431:SF11 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 FAMILY MEMBER DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 catalytic activity, acting on RNA#GO:0140098;transferase activity, transferring phosphorus-containing groups#GO:0016772;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;zinc ion binding#GO:0008270;catalytic activity#GO:0003824;transferase activity#GO:0016740;cation binding#GO:0043169;metal ion binding#GO:0046872;transition metal ion binding#GO:0046914;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094 nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;transcription by RNA polymerase III#GO:0006383;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;transcription by RNA polymerase II#GO:0006366;macromolecule metabolic process#GO:0043170;transcription by RNA polymerase I#GO:0006360;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058 RNA polymerase III complex#GO:0005666;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;RNA polymerase I complex#GO:0005736;nucleolus#GO:0005730;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;RNA polymerase II, holoenzyme#GO:0016591;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;RNA polymerase II, core complex#GO:0005665;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991 DNA metabolism protein#PC00009 Transcription regulation by bZIP transcription factor#P00055>RNA Polymerase II#P01388 HUMAN|HGNC=18251|UniProtKB=Q8IZQ5 Q8IZQ5 SELENOH PTHR33638:SF1 SELENOPROTEIN H SELENOPROTEIN H intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=9829|UniProtKB=P04049 P04049 RAF1 PTHR44329:SF22 SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED RAF PROTO-ONCOGENE SERINE_THREONINE-PROTEIN KINASE protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;MAP kinase kinase kinase activity#GO:0004709;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;signaling#GO:0023052;cell communication#GO:0007154;MAPK cascade#GO:0000165;intracellular signal transduction#GO:0035556 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cytosol#GO:0005829;mitochondrion#GO:0005739 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Ras Pathway#P04393>Raf#P04556;CCKR signaling map#P06959>c-RAF / RAF1#P07213;CCKR signaling map#P06959>RAF1#P07085;T cell activation#P00053>Raf#P01311;VEGF signaling pathway#P00056>Raf#P01417;PDGF signaling pathway#P00047>Raf#P01161;Endothelin signaling pathway#P00019>Raf-1#P00587;Interleukin signaling pathway#P00036>Raf#P00983;Integrin signalling pathway#P00034>Raf#P00924;B cell activation#P00010>Raf#P00381;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>Raf#P00893;Angiogenesis#P00005>Raf#P00243;EGF receptor signaling pathway#P00018>Raf-1#P00560;Angiotensin II-stimulated signaling through G proteins and beta-arrestin#P05911>Raf1#P05928;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Raf-1#P00843;FGF signaling pathway#P00021>Raf-1#P00643;Gonadotropin-releasing hormone receptor pathway#P06664>c-Raf#P06832 HUMAN|HGNC=14442|UniProtKB=Q8NDH6 Q8NDH6 ICA1L PTHR10164:SF5 ISLET CELL AUTOANTIGEN 1 ISLET CELL AUTOANTIGEN 1-LIKE PROTEIN molecular function regulator activity#GO:0098772;molecular sensor activity#GO:0140299 cellular component organization or biogenesis#GO:0071840;regulation of secretion#GO:0051046;regulation of localization#GO:0032879;regulation of transport#GO:0051049;cellular component organization#GO:0016043;cellular process#GO:0009987;regulation of biological process#GO:0050789;biological regulation#GO:0065007;membrane organization#GO:0061024 cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;secretory vesicle#GO:0099503;membrane#GO:0016020;vesicle membrane#GO:0012506;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;secretory granule membrane#GO:0030667;intracellular vesicle#GO:0097708;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HUMAN|HGNC=14244|UniProtKB=Q9NP72 Q9NP72 RAB18 PTHR24073:SF1242 DRAB5-RELATED RAS-RELATED PROTEIN RAB-18 hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817 establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle organization#GO:0006996;macromolecule localization#GO:0033036;intracellular protein localization#GO:0008104;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;cellular component organization#GO:0016043;protein transport#GO:0015031;localization#GO:0051179;cellular localization#GO:0051641;lipid droplet organization#GO:0034389 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 small GTPase#PC00208;G-protein#PC00020 HUMAN|HGNC=28189|UniProtKB=Q9BRQ3 Q9BRQ3 NUDT22 PTHR31835:SF1 URIDINE DIPHOSPHATE GLUCOSE PYROPHOSPHATASE URIDINE DIPHOSPHATE GLUCOSE PYROPHOSPHATASE NUDT22 hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817 phosphatase#PC00181 HUMAN|HGNC=20146|UniProtKB=Q6UW01 Q6UW01 CBLN3 PTHR22923:SF2 CEREBELLIN-RELATED CEREBELLIN-3 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 scaffold/adaptor protein#PC00226 HUMAN|HGNC=6113|UniProtKB=O43187 O43187 IRAK2 PTHR24419:SF2 INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE-LIKE 2 transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;histone kinase activity#GO:0035173;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;histone modifying activity#GO:0140993 positive regulation of response to stimulus#GO:0048584;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;response to other organism#GO:0051707;positive regulation of cellular process#GO:0048522;regulation of canonical NF-kappaB signal transduction#GO:0043122;cellular response to molecule of bacterial origin#GO:0071219;response to external stimulus#GO:0009605;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;mitotic cell cycle#GO:0000278;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;response to external biotic stimulus#GO:0043207;regulation of cell communication#GO:0010646;cell cycle#GO:0007049;positive regulation of signal transduction#GO:0009967;cellular response to biotic stimulus#GO:0071216;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cytokine-mediated signaling pathway#GO:0019221;lipopolysaccharide-mediated signaling pathway#GO:0031663;response to bacterium#GO:0009617;response to chemical#GO:0042221;response to cytokine#GO:0034097;response to lipid#GO:0033993;cellular response to lipid#GO:0071396;response to biotic stimulus#GO:0009607;cellular response to lipopolysaccharide#GO:0071222;positive regulation of biological process#GO:0048518;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;cellular process#GO:0009987;positive regulation of canonical NF-kappaB signal transduction#GO:0043123;response to lipopolysaccharide#GO:0032496;cell surface receptor signaling pathway#GO:0007166;response to stimulus#GO:0050896;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;regulation of biological process#GO:0050789;response to molecule of bacterial origin#GO:0002237;cellular response to cytokine stimulus#GO:0071345;positive regulation of signaling#GO:0023056;response to peptide#GO:1901652;cellular response to chemical stimulus#GO:0070887;regulation of intracellular signal transduction#GO:1902531;response to oxygen-containing compound#GO:1901700;regulation of signaling#GO:0023051 nucleus#GO:0005634;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=24279|UniProtKB=Q9BZJ4 Q9BZJ4 SLC25A39 PTHR45760:SF1 FI19922P1-RELATED MITOCHONDRIAL GLUTATHIONE TRANSPORTER SLC25A39 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=3118|UniProtKB=Q16254 Q16254 E2F4 PTHR12081:SF42 TRANSCRIPTION FACTOR E2F TRANSCRIPTION FACTOR E2F4 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677 regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575 helix-turn-helix transcription factor#PC00116;gene-specific transcriptional regulator#PC00264;winged helix/forkhead transcription factor#PC00246 HUMAN|HGNC=21077|UniProtKB=Q8N1G2 Q8N1G2 CMTR1 PTHR16121:SF0 CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1-RELATED CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1 methyltransferase activity#GO:0008168;O-methyltransferase activity#GO:0008171;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;transferase activity#GO:0016740;RNA methyltransferase activity#GO:0008173;catalytic activity, acting on RNA#GO:0140098 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HUMAN|HGNC=16276|UniProtKB=Q9C035 Q9C035 TRIM5 PTHR24103:SF416 E3 UBIQUITIN-PROTEIN LIGASE TRIM TRIPARTITE MOTIF-CONTAINING PROTEIN 5 kinase binding#GO:0019900;binding#GO:0005488;acyltransferase activity#GO:0016746;enzyme binding#GO:0019899;ubiquitin protein ligase activity#GO:0061630;protein kinase binding#GO:0019901;ubiquitin-like protein transferase activity#GO:0019787;protein binding#GO:0005515;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;identical protein binding#GO:0042802;aminoacyltransferase activity#GO:0016755 response to external biotic stimulus#GO:0043207;regulation of cell communication#GO:0010646;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;positive regulation of signal transduction#GO:0009967;response to external stimulus#GO:0009605;defense response#GO:0006952;regulation of gene expression#GO:0010468;innate immune response#GO:0045087;regulation of biosynthetic process#GO:0009889;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;response to other organism#GO:0051707;positive regulation of response to stimulus#GO:0048584;positive regulation of cellular process#GO:0048522;immune response#GO:0006955;regulation of canonical NF-kappaB signal transduction#GO:0043122;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of protein localization#GO:0032880;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;immune system process#GO:0002376;regulation of intracellular signal transduction#GO:1902531;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;regulation of localization#GO:0032879;positive regulation of canonical NF-kappaB signal transduction#GO:0043123;defense response to other organism#GO:0098542;defense response to symbiont#GO:0140546;positive regulation of biological process#GO:0048518;response to biotic stimulus#GO:0009607;response to stress#GO:0006950 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=15486|UniProtKB=Q9NZQ3 Q9NZQ3 NCKIPSD PTHR13357:SF1 SH3 ADAPTER PROTEIN SPIN90 NCK INTERACTING PROTEIN WITH SH3 DOMAIN NCK-INTERACTING PROTEIN WITH SH3 DOMAIN protein-containing complex binding#GO:0044877;binding#GO:0005488 transport#GO:0006810;establishment of localization#GO:0051234;endocytosis#GO:0006897;import into cell#GO:0098657;localization#GO:0051179 scaffold/adaptor protein#PC00226 HUMAN|HGNC=17367|UniProtKB=Q9NWB7 Q9NWB7 IFT57 PTHR16011:SF0 IFT57/HIPPI INTRAFLAGELLAR TRANSPORT PROTEIN 57 HOMOLOG cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cell projection assembly#GO:0030031;establishment of localization in cell#GO:0051649;cytoskeleton-dependent intracellular transport#GO:0030705;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;intracellular transport#GO:0046907;plasma membrane bounded cell projection assembly#GO:0120031;transport#GO:0006810;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;cilium assembly#GO:0060271;cellular component organization#GO:0016043;microtubule-based movement#GO:0007018;cell projection organization#GO:0030030;intraciliary transport#GO:0042073;organelle assembly#GO:0070925;microtubule-based transport#GO:0099111;cellular localization#GO:0051641;non-motile cilium assembly#GO:1905515;localization#GO:0051179;cilium organization#GO:0044782 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;intraciliary transport particle#GO:0030990;cilium#GO:0005929;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;microtubule cytoskeleton#GO:0015630;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;Golgi apparatus#GO:0005794;microtubule organizing center#GO:0005815;intraciliary transport particle B#GO:0030992;membraneless organelle#GO:0043228 structural protein#PC00211 Huntington disease#P00029>Hip-12#P00763;Huntington disease#P00029>Hippi#P00794 HUMAN|HGNC=12035|UniProtKB=O00463 O00463 TRAF5 PTHR10131:SF83 TNF RECEPTOR ASSOCIATED FACTOR TNF RECEPTOR-ASSOCIATED FACTOR 5 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;signaling adaptor activity#GO:0035591 cell communication#GO:0007154;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of cell communication#GO:0010646;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell surface receptor signaling pathway#GO:0007166;regulation of response to stimulus#GO:0048583;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;signal transduction#GO:0007165;regulation of canonical NF-kappaB signal transduction#GO:0043122;cellular process#GO:0009987 cell periphery#GO:0071944;cytoplasmic side of membrane#GO:0098562;cytoplasmic side of plasma membrane#GO:0009898;membrane#GO:0016020;plasma membrane#GO:0005886;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=10762|UniProtKB=Q53H47 Q53H47 SETMAR PTHR46060:SF2 MARINER MOS1 TRANSPOSASE-LIKE PROTEIN HISTONE-LYSINE N-METHYLTRANSFERASE SETMAR protein binding#GO:0005515;DNA endonuclease activity#GO:0004520;nuclease activity#GO:0004518;histone modifying activity#GO:0140993;lysine N-methyltransferase activity#GO:0016278;methyltransferase activity#GO:0008168;binding#GO:0005488;histone methyltransferase activity#GO:0042054;enzyme binding#GO:0019899;single-stranded DNA binding#GO:0003697;protein-lysine N-methyltransferase activity#GO:0016279;catalytic activity, acting on DNA#GO:0140097;transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;histone H3K36 methyltransferase activity#GO:0046975;hydrolase activity#GO:0016787;DNA binding#GO:0003677;histone H3 methyltransferase activity#GO:0140938;double-stranded DNA binding#GO:0003690;histone H3K4 methyltransferase activity#GO:0042800;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;nucleic acid binding#GO:0003676;N-methyltransferase activity#GO:0008170;catalytic activity, acting on a protein#GO:0140096;endonuclease activity#GO:0004519;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;protein methyltransferase activity#GO:0008276;hydrolase activity, acting on ester bonds#GO:0016788;DNA nuclease activity#GO:0004536 signal transduction#GO:0007165;cellular process#GO:0009987;response to stress#GO:0006950;regulation of cell cycle process#GO:0010564;cell cycle checkpoint signaling#GO:0000075;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;double-strand break repair#GO:0006302;negative regulation of cell cycle#GO:0045786;regulation of biological process#GO:0050789;cell cycle process#GO:0022402;negative regulation of biological process#GO:0048519;negative regulation of cell cycle phase transition#GO:1901988;regulation of cell cycle#GO:0051726;signaling#GO:0023052;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;negative regulation of mitotic cell cycle#GO:0045930;DNA-templated DNA replication#GO:0006261;regulation of mitotic cell cycle#GO:0007346;mitotic DNA integrity checkpoint signaling#GO:0044774;DNA integrity checkpoint signaling#GO:0031570;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;replication fork processing#GO:0031297;DNA damage response#GO:0006974;negative regulation of cell cycle process#GO:0010948;DNA repair#GO:0006281;negative regulation of cellular process#GO:0048523;mitotic cell cycle process#GO:1903047;macromolecule metabolic process#GO:0043170;DNA double-strand break processing#GO:0000729;double-strand break repair via nonhomologous end joining#GO:0006303;DNA replication#GO:0006260;cellular response to stimulus#GO:0051716;regulation of cell cycle phase transition#GO:1901987;cell cycle#GO:0007049;mitotic cell cycle checkpoint signaling#GO:0007093;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mitotic cell cycle#GO:0000278;regulation of cellular process#GO:0050794;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 condensed chromosome#GO:0000793;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;site of DNA damage#GO:0090734;membrane-bounded organelle#GO:0043227;site of double-strand break#GO:0035861;chromosome#GO:0005694;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232 viral or transposable element protein#PC00237 HUMAN|HGNC=13607|UniProtKB=Q9UKB1 Q9UKB1 FBXW11 PTHR44129:SF4 WD REPEAT-CONTAINING PROTEIN POP1 F-BOX_WD REPEAT-CONTAINING PROTEIN 11 transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659 proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152 catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ubiquitin ligase complex#GO:0000151;intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687;membrane-bounded organelle#GO:0043227;chromosome#GO:0005694;kinetochore#GO:0000776;cellular anatomical structure#GO:0110165;organelle#GO:0043226;SCF ubiquitin ligase complex#GO:0019005;intracellular membrane-bounded organelle#GO:0043231;cullin-RING ubiquitin ligase complex#GO:0031461;cytoskeleton#GO:0005856;chromosome, centromeric region#GO:0000775;condensed chromosome#GO:0000793;microtubule organizing center#GO:0005815;centrosome#GO:0005813;transferase complex#GO:1990234;membraneless organelle#GO:0043228;intracellular protein-containing complex#GO:0140535;condensed chromosome, centromeric region#GO:0000779;microtubule cytoskeleton#GO:0015630;nucleus#GO:0005634;protein-containing complex#GO:0032991;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232 Parkinson disease#P00049>hSel10#P01240;Wnt signaling pathway#P00057>betaTrCP#P01454;Hedgehog signaling pathway#P00025>Slimb#P00683 HUMAN|HGNC=20155|UniProtKB=Q86U06 Q86U06 RBM23 PTHR48036:SF3 SPLICING FACTOR (PAD-1), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G15810)-RELATED RNA-BINDING PROTEIN 23-RELATED binding#GO:0005488;ribonucleoprotein complex binding#GO:0043021;protein-containing complex binding#GO:0044877 regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of mRNA processing#GO:0050684;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of mRNA metabolic process#GO:1903311;regulation of biosynthetic process#GO:0009889 RNA processing factor#PC00147;RNA metabolism protein#PC00031;RNA splicing factor#PC00148 HUMAN|HGNC=11735|UniProtKB=Q9BXU3 Q9BXU3 TEX13A PTHR23111:SF64 ZINC FINGER PROTEIN TESTIS-EXPRESSED PROTEIN 13A mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 HUMAN|HGNC=16848|UniProtKB=Q6UXZ3 Q6UXZ3 CD300LD PTHR11860:SF108 POLYMERIC-IMMUNOGLOBULIN RECEPTOR CMRF35-LIKE MOLECULE 5 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;immune response-activating signaling pathway#GO:0002757;cellular process#GO:0009987;signal transduction#GO:0007165;activation of immune response#GO:0002253;positive regulation of biological process#GO:0048518;positive regulation of immune system process#GO:0002684;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;regulation of immune response#GO:0050776;immune system process#GO:0002376;cell communication#GO:0007154;immune response-regulating signaling pathway#GO:0002764;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signaling#GO:0023052;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=17867|UniProtKB=Q9Y639 Q9Y639 NPTN PTHR10075:SF108 BASIGIN RELATED NEUROPLASTIN cell adhesion molecule#PC00069 HUMAN|HGNC=17935|UniProtKB=Q9UJ71 Q9UJ71 CD207 PTHR22802:SF14 C-TYPE LECTIN SUPERFAMILY MEMBER C-TYPE LECTIN DOMAIN FAMILY 4 MEMBER K binding#GO:0005488;pattern recognition receptor activity#GO:0038187;carbohydrate binding#GO:0030246;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 immune response#GO:0006955;immune system process#GO:0002376;response to stimulus#GO:0050896 plasma membrane#GO:0005886;cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;membrane#GO:0016020 membrane traffic protein#PC00150 HUMAN|HGNC=10017|UniProtKB=Q99578 Q99578 RIT2 PTHR24070:SF203 RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY GTP-BINDING PROTEIN RIT2 hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;calmodulin binding#GO:0005516;ribonucleoside triphosphate phosphatase activity#GO:0017111;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924;protein binding#GO:0005515;hydrolase activity#GO:0016787 positive regulation of cell projection organization#GO:0031346;positive regulation of cellular component organization#GO:0051130;Ras protein signal transduction#GO:0007265;positive regulation of neuron projection development#GO:0010976;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signaling#GO:0023052;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;regulation of cell projection organization#GO:0031344;regulation of plasma membrane bounded cell projection organization#GO:0120035;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165;regulation of neuron projection development#GO:0010975;positive regulation of biological process#GO:0048518;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 small GTPase#PC00208 HUMAN|HGNC=19334|UniProtKB=Q8NBA8 Q8NBA8 DTWD2 PTHR21392:SF0 TRNA-URIDINE AMINOCARBOXYPROPYLTRANSFERASE 2 TRNA-URIDINE AMINOCARBOXYPROPYLTRANSFERASE 2 HUMAN|HGNC=13541|UniProtKB=O43861 O43861 ATP9B PTHR24092:SF50 PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE PHOSPHOLIPID-TRANSPORTING ATPASE IIB-RELATED intramembrane lipid carrier activity#GO:0140303;lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104;transporter activity#GO:0005215;ATP-dependent activity#GO:0140657;ATPase-coupled intramembrane lipid carrier activity#GO:0140326 lipid localization#GO:0010876;localization#GO:0051179;regulation of biological quality#GO:0065008;cellular component organization#GO:0016043;organophosphate ester transport#GO:0015748;endocytosis#GO:0006897;lipid translocation#GO:0034204;Golgi vesicle transport#GO:0048193;transport#GO:0006810;cellular component organization or biogenesis#GO:0071840;import into cell#GO:0098657;establishment of localization#GO:0051234;regulation of membrane lipid distribution#GO:0097035;macromolecule localization#GO:0033036;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;cellular process#GO:0009987;lipid transport#GO:0006869;vesicle-mediated transport#GO:0016192;membrane organization#GO:0061024;biological regulation#GO:0065007;phospholipid transport#GO:0015914;phospholipid translocation#GO:0045332 Golgi apparatus#GO:0005794;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;cell periphery#GO:0071944;endomembrane system#GO:0012505;plasma membrane#GO:0005886;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;endosome#GO:0005768;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 transporter#PC00227;primary active transporter#PC00068 HUMAN|HGNC=16997|UniProtKB=Q13015 Q13015 MLLT11 PTHR15404:SF2 PROTEIN AF1Q PROTEIN AF1Q positive regulation of cellular component organization#GO:0051130;regulation of release of cytochrome c from mitochondria#GO:0090199;regulation of RNA metabolic process#GO:0051252;regulation of biological quality#GO:0065008;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;positive regulation of organelle organization#GO:0010638;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of mitochondrion organization#GO:0010821;regulation of organelle organization#GO:0033043;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of membrane potential#GO:0042391;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893 cytosol#GO:0005829;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=17975|UniProtKB=Q9BRK0 Q9BRK0 REEP2 PTHR12300:SF29 HVA22-LIKE PROTEINS RECEPTOR EXPRESSION-ENHANCING PROTEIN 2 protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;G protein-coupled receptor binding#GO:0001664;tubulin binding#GO:0015631;microtubule binding#GO:0008017;signaling receptor binding#GO:0005102;binding#GO:0005488 cellular component organization or biogenesis#GO:0071840;endoplasmic reticulum tubular network organization#GO:0071786;endomembrane system organization#GO:0010256;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;endoplasmic reticulum organization#GO:0007029 intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;supramolecular fiber#GO:0099512;membrane-bounded organelle#GO:0043227;microtubule#GO:0005874;cytoplasmic microtubule#GO:0005881;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;cytoskeleton#GO:0005856;organelle membrane#GO:0031090;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;endoplasmic reticulum tubular network#GO:0071782;membrane#GO:0016020;microtubule cytoskeleton#GO:0015630;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;endomembrane system#GO:0012505;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080 membrane traffic protein#PC00150 HUMAN|HGNC=18703|UniProtKB=Q9NVQ4 Q9NVQ4 FAIM PTHR13088:SF3 FAS APOPTOTIC INHIBITORY MOLECULE FAIM FAS APOPTOTIC INHIBITORY MOLECULE 1 negative regulation of cellular process#GO:0048523;regulation of apoptotic process#GO:0042981;regulation of response to stimulus#GO:0048583;negative regulation of programmed cell death#GO:0043069;negative regulation of extrinsic apoptotic signaling pathway#GO:2001237;negative regulation of apoptotic process#GO:0043066;negative regulation of response to stimulus#GO:0048585;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;negative regulation of signaling#GO:0023057;negative regulation of apoptotic signaling pathway#GO:2001234;regulation of apoptotic signaling pathway#GO:2001233;regulation of signaling#GO:0023051;negative regulation of cell communication#GO:0010648;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;regulation of extrinsic apoptotic signaling pathway#GO:2001236;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646 HUMAN|HGNC=30718|UniProtKB=P59910 P59910 DNAJB13 PTHR24078:SF553 DNAJ HOMOLOG SUBFAMILY C MEMBER DNAJ HOMOLOG SUBFAMILY B MEMBER 13 protein binding#GO:0005515;binding#GO:0005488;protein-folding chaperone binding#GO:0051087 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;protein folding#GO:0006457;biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 chaperone#PC00072 HUMAN|HGNC=6389|UniProtKB=Q9BW19 Q9BW19 KIFC1 PTHR24115:SF1045 KINESIN-RELATED KINESIN-LIKE PROTEIN KIFC1 catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;macromolecular conformation isomerase activity#GO:0120543;tubulin binding#GO:0015631;isomerase activity#GO:0016853;ribonucleoside triphosphate phosphatase activity#GO:0017111;polypeptide conformation or assembly isomerase activity#GO:0120544;microtubule binding#GO:0008017;hydrolase activity#GO:0016787;microtubule motor activity#GO:0003777;ATP hydrolysis activity#GO:0016887;hydrolase activity, acting on acid anhydrides#GO:0016817;cytoskeletal protein binding#GO:0008092;cytoskeletal motor activity#GO:0003774;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;ATP-dependent activity#GO:0140657;protein binding#GO:0005515 nuclear division#GO:0000280;organelle assembly#GO:0070925;microtubule cytoskeleton organization#GO:0000226;organelle fission#GO:0048285;cellular component organization#GO:0016043;sister chromatid segregation#GO:0000819;microtubule cytoskeleton organization involved in mitosis#GO:1902850;membraneless organelle assembly#GO:0140694;nuclear chromosome segregation#GO:0098813;cell cycle#GO:0007049;cell cycle process#GO:0022402;mitotic nuclear division#GO:0140014;mitotic spindle organization#GO:0007052;microtubule-based movement#GO:0007018;mitotic cell cycle#GO:0000278;chromosome segregation#GO:0007059;cellular component organization or biogenesis#GO:0071840;spindle organization#GO:0007051;microtubule-based process#GO:0007017;chromosome organization#GO:0051276;mitotic cell cycle process#GO:1903047;spindle assembly#GO:0051225;organelle organization#GO:0006996;mitotic sister chromatid segregation#GO:0000070;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;mitotic spindle assembly#GO:0090307;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;mitotic spindle#GO:0072686;intracellular organelle#GO:0043229;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membrane-bounded organelle#GO:0043227;microtubule cytoskeleton#GO:0015630;nucleus#GO:0005634;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;spindle#GO:0005819;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228 microtubule or microtubule-binding cytoskeletal protein#PC00157;microtubule binding motor protein#PC00156 HUMAN|HGNC=28053|UniProtKB=Q9UJL9 Q9UJL9 ZFP69B PTHR24381:SF135 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 69 HOMOLOG B sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=30350|UniProtKB=Q9H9Y2 Q9H9Y2 RPF1 PTHR22734:SF3 U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4 RIBOSOME PRODUCTION FACTOR 1 RNA binding#GO:0003723;rRNA binding#GO:0019843;binding#GO:0005488;nucleic acid binding#GO:0003676 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;maturation of 5.8S rRNA#GO:0000460;ribosome biogenesis#GO:0042254;ribosomal large subunit biogenesis#GO:0042273;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;maturation of LSU-rRNA#GO:0000470;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170 nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;membraneless organelle#GO:0043228;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;ribonucleoprotein complex#GO:1990904;preribosome#GO:0030684;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;preribosome, large subunit precursor#GO:0030687 RNA splicing factor#PC00148;RNA processing factor#PC00147 HUMAN|HGNC=11495|UniProtKB=Q92777 Q92777 SYN2 PTHR10841:SF20 SYNAPSIN SYNAPSIN-2 cytoskeletal adaptor activity#GO:0008093;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 cellular component organization#GO:0016043;cell junction organization#GO:0034330;organelle localization#GO:0051640;synapse organization#GO:0050808;localization#GO:0051179;cellular localization#GO:0051641;vesicle localization#GO:0051648;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;synaptic vesicle localization#GO:0097479;vesicle-mediated transport#GO:0016192;transport#GO:0006810;synaptic vesicle cycle#GO:0099504;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;vesicle-mediated transport in synapse#GO:0099003 intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular vesicle#GO:0097708;synaptic vesicle membrane#GO:0030672;vesicle#GO:0031982;synaptic vesicle#GO:0008021;organelle#GO:0043226;cellular anatomical structure#GO:0110165;synapse#GO:0045202;intracellular membrane-bounded organelle#GO:0043231;cell junction#GO:0030054;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;membrane#GO:0016020;secretory vesicle#GO:0099503;presynapse#GO:0098793;transport vesicle#GO:0030133;endomembrane system#GO:0012505;transport vesicle membrane#GO:0030658;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737 membrane traffic protein#PC00150;membrane trafficking regulatory protein#PC00151 Synaptic vesicle trafficking#P05734>Synapsin#P05775 HUMAN|HGNC=8368|UniProtKB=Q15622 Q15622 OR7A5 PTHR48001:SF177 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 7A5 transmembrane signal receptor#PC00197 HUMAN|HGNC=12616|UniProtKB=Q9UMW8 Q9UMW8 USP18 PTHR24006:SF796 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBL CARBOXYL-TERMINAL HYDROLASE 18 deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;cysteine-type deubiquitinase activity#GO:0004843;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783 regulation of biological quality#GO:0065008;biological regulation#GO:0065007;regulation of protein stability#GO:0031647 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cytosol#GO:0005829;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 cysteine protease#PC00081;protease#PC00190 HUMAN|HGNC=27052|UniProtKB=Q6IPR1 Q6IPR1 ETFRF1 PTHR21024:SF0 GROWTH HORMONE-INDUCIBLE SOLUBLE PROTEIN-RELATED ELECTRON TRANSFER FLAVOPROTEIN REGULATORY FACTOR 1 regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of metabolic process#GO:0019222;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794 mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=11397|UniProtKB=O00444 O00444 PLK4 PTHR24345:SF89 SERINE/THREONINE-PROTEIN KINASE PLK SERINE_THREONINE-PROTEIN KINASE PLK4 kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226;mitotic cell cycle process#GO:1903047;microtubule-based process#GO:0007017;cell cycle#GO:0007049;organelle organization#GO:0006996;cellular component organization#GO:0016043;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cell cycle process#GO:0022402;cellular process#GO:0009987;mitotic cell cycle#GO:0000278;mitotic spindle organization#GO:0007052;cytoskeleton organization#GO:0007010 microtubule cytoskeleton#GO:0015630;condensed chromosome, centromeric region#GO:0000779;nucleus#GO:0005634;supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;spindle#GO:0005819;condensed chromosome#GO:0000793;cytoskeleton#GO:0005856;chromosome, centromeric region#GO:0000775;membraneless organelle#GO:0043228;spindle pole#GO:0000922;chromosome#GO:0005694;kinetochore#GO:0000776;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=30858|UniProtKB=Q15029 Q15029 EFTUD2 PTHR42908:SF6 TRANSLATION ELONGATION FACTOR-RELATED 116 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT ribonucleoside triphosphate phosphatase activity#GO:0017111;translation elongation factor activity#GO:0003746;translation factor activity#GO:0180051;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;snRNA binding#GO:0017069;hydrolase activity#GO:0016787;RNA binding#GO:0003723;nucleic acid binding#GO:0003676;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;GTPase activity#GO:0003924 nucleic acid biosynthetic process#GO:0141187;translation#GO:0006412;RNA splicing, via transesterification reactions#GO:0000375;protein metabolic process#GO:0019538;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;protein biosynthetic process#GO:0160307;RNA splicing#GO:0008380;translational elongation#GO:0006414;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;gene expression#GO:0010467 ribonucleoprotein complex#GO:1990904;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;spliceosomal tri-snRNP complex#GO:0097526;spliceosomal snRNP complex#GO:0097525;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;spliceosomal complex#GO:0005681;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;U2-type spliceosomal complex#GO:0005684;nuclear protein-containing complex#GO:0140513;Sm-like protein family complex#GO:0120114;catalytic step 2 spliceosome#GO:0071013;small nuclear ribonucleoprotein complex#GO:0030532;cytosol#GO:0005829;nucleus#GO:0005634;U4/U6 x U5 tri-snRNP complex#GO:0046540;protein-containing complex#GO:0032991;cytoplasm#GO:0005737 translation elongation factor#PC00222 HUMAN|HGNC=73|UniProtKB=P45844 P45844 ABCG1 PTHR48041:SF90 ABC TRANSPORTER G FAMILY MEMBER 28 ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 1 ATPase-coupled transmembrane transporter activity#GO:0042626;transmembrane transporter activity#GO:0022857;ATP-dependent activity#GO:0140657;transporter activity#GO:0005215;primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804 localization#GO:0051179;transmembrane transport#GO:0055085;organic hydroxy compound transport#GO:0015850;lipid localization#GO:0010876;homeostatic process#GO:0042592;lipid homeostasis#GO:0055088;establishment of localization#GO:0051234;cholesterol homeostasis#GO:0042632;sterol transport#GO:0015918;transport#GO:0006810;chemical homeostasis#GO:0048878;lipid transport#GO:0006869;macromolecule localization#GO:0033036;cholesterol transport#GO:0030301;cholesterol efflux#GO:0033344;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227;primary active transporter#PC00068;ATP-binding cassette (ABC) transporter#PC00003 HUMAN|HGNC=21915|UniProtKB=Q9BSE4 Q9BSE4 HERPUD2 PTHR12943:SF5 HOMOCYSTEINE-RESPONSIVE ENDOPLASMIC RETICULUM-RESIDENT UNIQUITIN-LIKE DOMAIN HERPUD PROTEIN FAMILY MEMBER HOMOCYSTEINE-RESPONSIVE ENDOPLASMIC RETICULUM-RESIDENT UBIQUITIN-LIKE DOMAIN MEMBER 2 PROTEIN regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;response to topologically incorrect protein#GO:0035966;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;response to unfolded protein#GO:0006986;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;response to endoplasmic reticulum stress#GO:0034976;cellular response to unfolded protein#GO:0034620;cellular response to topologically incorrect protein#GO:0035967;cellular response to stress#GO:0033554;biological regulation#GO:0065007;response to stress#GO:0006950;endoplasmic reticulum unfolded protein response#GO:0030968;cellular process#GO:0009987;signal transduction#GO:0007165 HUMAN|HGNC=21580|UniProtKB=Q5VV43 Q5VV43 KIAA0319 PTHR46182:SF1 FI19480P1 DYSLEXIA-ASSOCIATED PROTEIN KIAA0319 cell differentiation#GO:0030154;cell motility#GO:0048870;multicellular organismal process#GO:0032501;cell migration#GO:0016477;nervous system development#GO:0007399;cellular process#GO:0009987;neuron migration#GO:0001764;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;anatomical structure development#GO:0048856;system development#GO:0048731;neurogenesis#GO:0022008;animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502;generation of neurons#GO:0048699 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;vesicle#GO:0031982;cell periphery#GO:0071944;intracellular vesicle#GO:0097708;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=1745|UniProtKB=O00311 O00311 CDC7 PTHR11909:SF7 CASEIN KINASE-RELATED CELL DIVISION CYCLE 7-RELATED PROTEIN KINASE protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096 cell communication#GO:0007154;cellular response to stress#GO:0033554;recombinational repair#GO:0000725;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;double-strand break repair via homologous recombination#GO:0000724;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;DNA recombination#GO:0006310;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;signal transduction#GO:0007165;cellular process#GO:0009987;double-strand break repair via break-induced replication#GO:0000727;response to stress#GO:0006950 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=6621|UniProtKB=Q05469 Q05469 LIPE PTHR23025:SF3 TRIACYLGLYCEROL LIPASE HORMONE-SENSITIVE LIPASE hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;carboxylic ester hydrolase activity#GO:0052689;triacylglycerol lipase activity#GO:0004806;catalytic activity#GO:0003824;lipase activity#GO:0016298 lipid catabolic process#GO:0016042;cellular process#GO:0009987;primary metabolic process#GO:0044238;catabolic process#GO:0009056;glycerolipid metabolic process#GO:0046486;neutral lipid catabolic process#GO:0046461;lipid metabolic process#GO:0006629;triglyceride metabolic process#GO:0006641;metabolic process#GO:0008152;triglyceride catabolic process#GO:0019433;acylglycerol metabolic process#GO:0006639;glycerolipid catabolic process#GO:0046503;acylglycerol catabolic process#GO:0046464;neutral lipid metabolic process#GO:0006638 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 hydrolase#PC00121;lipase#PC00143;metabolite interconversion enzyme#PC00262 Triacylglycerol metabolism#P02782>Triacylglycerol lipase#P03205 HUMAN|HGNC=7155|UniProtKB=P03956 P03956 MMP1 PTHR10201:SF151 MATRIX METALLOPROTEINASE INTERSTITIAL COLLAGENASE catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222 catabolic process#GO:0009056;cellular component organization#GO:0016043;cellular process#GO:0009987;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;external encapsulating structure organization#GO:0045229;extracellular structure organization#GO:0043062;metabolic process#GO:0008152 metalloprotease#PC00153 Plasminogen activating cascade#P00050>MMP-1#P01252;Plasminogen activating cascade#P00050>pro-MMP-1#P01263;Alzheimer disease-presenilin pathway#P00004>Matrix metalloprotease#P00130 HUMAN|HGNC=24501|UniProtKB=Q58EX7 Q58EX7 PLEKHG4 PTHR45845:SF4 RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR-RELATED PURATROPHIN-1 guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=23304|UniProtKB=Q96NZ9 Q96NZ9 PRAP1 PTHR37861:SF1 PROLINE-RICH ACIDIC PROTEIN 1 PROLINE-RICH ACIDIC PROTEIN 1 HUMAN|HGNC=28541|UniProtKB=Q8N5U0 Q8N5U0 C11orf42 PTHR36872:SF1 GENE 5901-RELATED GENE 5901-RELATED 9+2 motile cilium#GO:0097729;cilium#GO:0005929;membrane-bounded organelle#GO:0043227;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;sperm flagellum#GO:0036126;cellular anatomical structure#GO:0110165;organelle#GO:0043226;motile cilium#GO:0031514 HUMAN|HGNC=2561|UniProtKB=P61073 P61073 CXCR4 PTHR10489:SF594 CELL ADHESION MOLECULE C-X-C CHEMOKINE RECEPTOR TYPE 4 cytokine receptor activity#GO:0004896;signaling receptor activity#GO:0038023;cytokine binding#GO:0019955;immune receptor activity#GO:0140375;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488;protein binding#GO:0005515;molecular transducer activity#GO:0060089 signaling#GO:0023052;response to stimulus#GO:0050896;central nervous system development#GO:0007417;cell differentiation#GO:0030154;regulation of biological process#GO:0050789;regulation of biological quality#GO:0065008;animal gross anatomical part developmental process#GO:0160108;immune system process#GO:0002376;cellular response to chemical stimulus#GO:0070887;positive regulation of cytosolic calcium ion concentration#GO:0007204;head development#GO:0060322;intracellular signaling cassette#GO:0141124;nervous system development#GO:0007399;response to chemical#GO:0042221;taxis#GO:0042330;cellular process#GO:0009987;signal transduction#GO:0007165;animal organ development#GO:0048513;multicellular organism development#GO:0007275;locomotion#GO:0040011;cell motility#GO:0048870;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;intracellular signal transduction#GO:0035556;system development#GO:0048731;cell chemotaxis#GO:0060326;anatomical structure development#GO:0048856;cell communication#GO:0007154;chemotaxis#GO:0006935;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;cell migration#GO:0016477;brain development#GO:0007420;immune response#GO:0006955;neurogenesis#GO:0022008;calcium-mediated signaling#GO:0019722;response to external stimulus#GO:0009605;cellular developmental process#GO:0048869;developmental process#GO:0032502 membrane#GO:0016020;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cell adhesion molecule#PC00069 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CHKR#P00854;Axon guidance mediated by Slit/Robo#P00008>Cxcr4#P00351 HUMAN|HGNC=16950|UniProtKB=O95630 O95630 STAMBP PTHR12947:SF8 AMSH-LIKE PROTEASE STAM-BINDING PROTEIN catalytic activity#GO:0003824;deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233 intracellular transport#GO:0046907;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;transport#GO:0006810;vacuolar transport#GO:0007034;establishment of localization#GO:0051234;endosomal transport#GO:0016197;regulation of small GTPase mediated signal transduction#GO:0051056;late endosome to vacuole transport via multivesicular body sorting pathway#GO:0032511;cellular process#GO:0009987;multivesicular body sorting pathway#GO:0071985;establishment of localization in cell#GO:0051649;negative regulation of response to stimulus#GO:0048585;vesicle-mediated transport#GO:0016192;endosome transport via multivesicular body sorting pathway#GO:0032509;negative regulation of signal transduction#GO:0009968;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;cellular localization#GO:0051641;negative regulation of intracellular signal transduction#GO:1902532;localization#GO:0051179;negative regulation of cell communication#GO:0010648;regulation of Ras protein signal transduction#GO:0046578;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;late endosome to vacuole transport#GO:0045324 cleavage furrow#GO:0032154;plasma membrane region#GO:0098590;endomembrane system#GO:0012505;plasma membrane#GO:0005886;cell division site#GO:0032153;cytoplasm#GO:0005737;membrane#GO:0016020;cell periphery#GO:0071944;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endosome#GO:0005768;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982 protease#PC00190;metalloprotease#PC00153 HUMAN|HGNC=7850|UniProtKB=P22392 P22392 NME2 PTHR11349:SF116 NUCLEOSIDE DIPHOSPHATE KINASE NUCLEOSIDE DIPHOSPHATE KINASE B nucleobase-containing compound kinase activity#GO:0019205;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;nucleoside diphosphate kinase activity#GO:0004550;phosphotransferase activity, phosphate group as acceptor#GO:0016776 biosynthetic process#GO:0009058;nucleoside triphosphate metabolic process#GO:0009141;cellular process#GO:0009987;metabolic process#GO:0008152;nucleoside triphosphate biosynthetic process#GO:0009142;phosphorus metabolic process#GO:0006793 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 transferase#PC00220;kinase#PC00137 De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>dTDP kinase#P02919;De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>dCDP kinase#P02914;De novo purine biosynthesis#P02738>dGDP kinase#P02889;De novo pyrimidine ribonucleotides biosythesis#P02740>CDP kinase#P02929;De novo purine biosynthesis#P02738>dADP kinase#P02907;De novo pyrimidine ribonucleotides biosythesis#P02740>UDP kinase#P02923;Salvage pyrimidine ribonucleotides#P02775>CDP kinase#P03156;De novo purine biosynthesis#P02738>GDP kinase#P02891;De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>dUDP kinase#P02912 HUMAN|HGNC=29386|UniProtKB=Q5T0F9 Q5T0F9 CC2D1B PTHR13076:SF5 COILED-COIL AND C2 DOMAIN-CONTAINING PROTEIN 1-LIKE COILED-COIL AND C2 DOMAIN-CONTAINING PROTEIN 1B sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=28389|UniProtKB=Q6ICG8 Q6ICG8 WBP2NL PTHR31606:SF2 WW DOMAIN BINDING PROTEIN 2, ISOFORM E POSTACROSOMAL SHEATH WW DOMAIN-BINDING PROTEIN DNA binding#GO:0003677;transcription regulator activity#GO:0140110;chromatin binding#GO:0003682;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription coactivator activity#GO:0003713;chromatin DNA binding#GO:0031490;transcription coregulator activity#GO:0003712 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of biological process#GO:0050789;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=26812|UniProtKB=Q8NAG6 Q8NAG6 ANKLE1 PTHR46427:SF1 ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 1 STRUCTURE-SPECIFIC ENDONUCLEASE ANKLE1 nuclease activity#GO:0004518;endonuclease activity#GO:0004519;catalytic activity, acting on DNA#GO:0140097;DNA endonuclease activity#GO:0004520;DNA nuclease activity#GO:0004536;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640 response to stimulus#GO:0050896;cell cycle process#GO:0022402;double-strand break repair via homologous recombination#GO:0000724;meiosis I#GO:0007127;meiotic cell cycle process#GO:1903046;cellular component organization#GO:0016043;reciprocal meiotic recombination#GO:0007131;cellular response to stress#GO:0033554;nuclear division#GO:0000280;cellular process#GO:0009987;response to stress#GO:0006950;organelle organization#GO:0006996;double-strand break repair#GO:0006302;cellular component organization or biogenesis#GO:0071840;DNA recombination#GO:0006310;DNA metabolic process#GO:0006259;meiotic cell cycle#GO:0051321;metabolic process#GO:0008152;homologous recombination#GO:0035825;reproductive process#GO:0022414;cellular response to stimulus#GO:0051716;reciprocal homologous recombination#GO:0140527;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cell cycle#GO:0007049;organelle fission#GO:0048285;sexual reproduction#GO:0019953;recombinational repair#GO:0000725;meiosis I cell cycle process#GO:0061982;nucleobase-containing compound metabolic process#GO:0006139;resolution of meiotic recombination intermediates#GO:0000712;meiotic nuclear division#GO:0140013;macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;DNA repair#GO:0006281 organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=1142|UniProtKB=Q9UIR0 Q9UIR0 BTNL2 PTHR24100:SF105 BUTYROPHILIN BUTYROPHILIN-LIKE PROTEIN 2 protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488 regulation of immune response#GO:0050776;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;immune response-activating cell surface receptor signaling pathway#GO:0002429;T cell receptor signaling pathway#GO:0050852;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of cytokine production#GO:0001817;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;immune system process#GO:0002376;immune response-regulating signaling pathway#GO:0002764;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signaling#GO:0023052;cell surface receptor signaling pathway#GO:0007166;immune response-activating signaling pathway#GO:0002757;positive regulation of immune system process#GO:0002684;cellular process#GO:0009987;signal transduction#GO:0007165;activation of immune response#GO:0002253;positive regulation of biological process#GO:0048518;antigen receptor-mediated signaling pathway#GO:0050851;regulation of multicellular organismal process#GO:0051239 plasma membrane#GO:0005886;cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=29356|UniProtKB=Q9C0F1 Q9C0F1 CEP44 PTHR31477:SF1 CENTROSOMAL PROTEIN OF 44 KDA CENTROSOMAL PROTEIN OF 44 KDA membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;cell cycle#GO:0007049;cell cycle process#GO:0022402;centrosome cycle#GO:0007098;organelle assembly#GO:0070925;centriole replication#GO:0007099;microtubule cytoskeleton organization#GO:0000226;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;centrosome duplication#GO:0051298;microtubule organizing center organization#GO:0031023 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;centrosome#GO:0005813;spindle#GO:0005819;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microtubule cytoskeleton#GO:0015630;spindle pole#GO:0000922 HUMAN|HGNC=4566|UniProtKB=P62993 P62993 GRB2 PTHR46037:SF4 PROTEIN ENHANCER OF SEVENLESS 2B GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2 protein binding#GO:0005515;growth factor receptor binding#GO:0070851;binding#GO:0005488;signaling receptor binding#GO:0005102 regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;regulation of MAPK cascade#GO:0043408;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of cell communication#GO:0010646;signaling#GO:0023052;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966 membrane-enclosed lumen#GO:0031974;membrane#GO:0016020;cell periphery#GO:0071944;nucleus#GO:0005634;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;plasma membrane#GO:0005886;nuclear protein-containing complex#GO:0140513;organelle lumen#GO:0043233;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;COP9 signalosome#GO:0008180;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 EGF receptor signaling pathway#P00018>Grb2#P00550;Angiogenesis#P00005>Grb2#P00252;T cell activation#P00053>Grb2#P01303;B cell activation#P00010>Grb2#P00372;FGF signaling pathway#P00021>Grb2#P00631;CCKR signaling map#P06959>GRB2#P07237;Integrin signalling pathway#P00034>Grb2#P00910;PDGF signaling pathway#P00047>Grb2#P01148;Ras Pathway#P04393>Grb2#P04544;Dopamine receptor mediated signaling pathway#P05912>Grb2#P05949;PI3 kinase pathway#P00048>Grb2#P01178;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>Grb2#P00892;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Grb#P00848;Interleukin signaling pathway#P00036>Grb2#P00971;Gonadotropin-releasing hormone receptor pathway#P06664>Grb2#P06856;Nicotine pharmacodynamics pathway#P06587>Grb2#P06596;Angiogenesis#P00005>Grb2#P00234 HUMAN|HGNC=17496|UniProtKB=Q5VSY0 Q5VSY0 GKAP1 PTHR14899:SF0 G KINASE ANCHORING PROTEIN 1 G KINASE-ANCHORING PROTEIN 1 cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007 scaffold/adaptor protein#PC00226 HUMAN|HGNC=24949|UniProtKB=Q01804 Q01804 OTUD4 PTHR12419:SF9 OTU DOMAIN CONTAINING PROTEIN OTU DOMAIN-CONTAINING PROTEIN 4 catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;cysteine-type deubiquitinase activity#GO:0004843;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005 regulation of innate immune response#GO:0045088;regulation of cytokine-mediated signaling pathway#GO:0001959;regulation of response to stress#GO:0080134;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;negative regulation of cytokine-mediated signaling pathway#GO:0001960;regulation of response to external stimulus#GO:0032101;negative regulation of response to stimulus#GO:0048585;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of immune system process#GO:0002683;regulation of response to cytokine stimulus#GO:0060759;negative regulation of cell communication#GO:0010648;negative regulation of signaling#GO:0023057;regulation of defense response#GO:0031347;regulation of signaling#GO:0023051;regulation of immune response#GO:0050776;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of cell communication#GO:0010646;regulation of response to biotic stimulus#GO:0002831;negative regulation of response to cytokine stimulus#GO:0060761;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789 cysteine protease#PC00081 HUMAN|HGNC=12218|UniProtKB=A0A578 A0A578 TRBV5-1 PTHR23268:SF106 T-CELL RECEPTOR BETA CHAIN T CELL RECEPTOR BETA VARIABLE 5-1 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=16653|UniProtKB=Q96GC5 Q96GC5 MRPL48 PTHR13473:SF0 MITOCHONDRIAL RIBOSOMAL PROTEIN L48 LARGE RIBOSOMAL SUBUNIT PROTEIN ML48 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 biosynthetic process#GO:0009058;mitochondrial translation#GO:0032543;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;mitochondrial gene expression#GO:0140053;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;translation#GO:0006412;metabolic process#GO:0008152 intracellular anatomical structure#GO:0005622;organellar ribosome#GO:0000313;mitochondrial ribosome#GO:0005761;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;ribosome#GO:0005840;mitochondrion#GO:0005739;membraneless organelle#GO:0043228;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974 ribosomal protein#PC00202;translational protein#PC00263 HUMAN|HGNC=12339|UniProtKB=O94759 O94759 TRPM2 PTHR13800:SF2 TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6 TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 2 ligand-gated calcium channel activity#GO:0099604;calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;gated channel activity#GO:0022836;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873;transporter activity#GO:0005215;channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation channel activity#GO:0005261;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;ligand-gated monoatomic cation channel activity#GO:0099094 release of sequestered calcium ion into cytosol#GO:0051209;cellular process#GO:0009987;calcium ion transmembrane transport#GO:0070588;monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;transport#GO:0006810;monoatomic ion transport#GO:0006811;calcium ion transport#GO:0006816;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;calcium ion transmembrane import into cytosol#GO:0097553;localization#GO:0051179;monoatomic cation transport#GO:0006812 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=11304|UniProtKB=P49458 P49458 SRP9 PTHR12834:SF12 SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN establishment of protein localization to organelle#GO:0072594;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;protein targeting to ER#GO:0045047;protein targeting to membrane#GO:0006612;localization within membrane#GO:0051668;SRP-dependent cotranslational protein targeting to membrane#GO:0006614;protein targeting#GO:0006605;establishment of protein localization to endoplasmic reticulum#GO:0072599;establishment of protein localization to membrane#GO:0090150;establishment of protein localization#GO:0045184;cellular process#GO:0009987 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;signal recognition particle, endoplasmic reticulum targeting#GO:0005786;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904 RNA metabolism protein#PC00031 HUMAN|HGNC=2558|UniProtKB=P49238 P49238 CX3CR1 PTHR10489:SF955 CELL ADHESION MOLECULE CX3C CHEMOKINE RECEPTOR 1 protein binding#GO:0005515;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488;signaling receptor activity#GO:0038023;cytokine binding#GO:0019955;G protein-coupled receptor activity#GO:0004930;immune receptor activity#GO:0140375;cytokine receptor activity#GO:0004896 calcium-mediated signaling#GO:0019722;response to external stimulus#GO:0009605;cellular process#GO:0009987;signal transduction#GO:0007165;immune response#GO:0006955;cell migration#GO:0016477;response to chemical#GO:0042221;taxis#GO:0042330;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;positive regulation of cytosolic calcium ion concentration#GO:0007204;cellular response to chemical stimulus#GO:0070887;immune system process#GO:0002376;chemotaxis#GO:0006935;cell communication#GO:0007154;regulation of biological quality#GO:0065008;intracellular signal transduction#GO:0035556;cell chemotaxis#GO:0060326;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;cell motility#GO:0048870;response to stimulus#GO:0050896;locomotion#GO:0040011;signaling#GO:0023052 cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;plasma membrane#GO:0005886;membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944 cell adhesion molecule#PC00069 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CHKR#P00854 HUMAN|HGNC=6348|UniProtKB=O43474 O43474 KLF4 PTHR23235:SF117 KRUEPPEL-LIKE TRANSCRIPTION FACTOR KRUEPPEL-LIKE FACTOR 4 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 C2H2 zinc finger transcription factor#PC00248 CCKR signaling map#P06959>KLF4#P07227 HUMAN|HGNC=5591|UniProtKB=P01768 P01768 IGHV3-30 PTHR23266:SF241 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 3-30-RELATED antigen binding#GO:0003823;binding#GO:0005488 immune effector process#GO:0002252;immune system process#GO:0002376;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;immune response#GO:0006955;adaptive immune response#GO:0002250;response to stimulus#GO:0050896 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=27356|UniProtKB=P0DJ93 P0DJ93 SMIM13 PTHR36877:SF1 SMALL INTEGRAL MEMBRANE PROTEIN 13 SMALL INTEGRAL MEMBRANE PROTEIN 13 HUMAN|HGNC=4446|UniProtKB=O43292 O43292 GPAA1 PTHR13304:SF0 GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN GPI-ANCHOR TRANSAMIDASE COMPONENT GPAA1 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;biosynthetic process#GO:0009058;GPI anchored protein biosynthesis#GO:0180046;protein maturation#GO:0051604;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238 membrane#GO:0016020;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;peptidase complex#GO:1905368;cytoplasm#GO:0005737;caspase complex#GO:0008303;endoplasmic reticulum membrane#GO:0005789;endopeptidase complex#GO:1905369;transferase complex#GO:1990234;endoplasmic reticulum#GO:0005783;endoplasmic reticulum protein-containing complex#GO:0140534;organelle membrane#GO:0031090;membrane protein complex#GO:0098796;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;endoplasmic reticulum subcompartment#GO:0098827;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=16844|UniProtKB=Q02930 Q02930 CREB5 PTHR19304:SF8 CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 5 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 basic leucine zipper transcription factor#PC00056 Transcription regulation by bZIP transcription factor#P00055>CREB#P01383;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>CREB#P00713 HUMAN|HGNC=24212|UniProtKB=Q8N5K1 Q8N5K1 CISD2 PTHR13680:SF33 CDGSH IRON-SULFUR DOMAIN-CONTAINING PROTEIN 1 CDGSH IRON-SULFUR DOMAIN-CONTAINING PROTEIN 2 iron-sulfur cluster binding#GO:0051536;small molecule binding#GO:0036094;transferase activity#GO:0016740;binding#GO:0005488;catalytic activity#GO:0003824;transaminase activity#GO:0008483 intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;chemical homeostasis#GO:0048878;metabolic process#GO:0008152;autophagy of mitochondrion#GO:0000422;autophagy#GO:0006914;cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801;process utilizing autophagic mechanism#GO:0061919;inorganic ion homeostasis#GO:0098771;homeostatic process#GO:0042592;catabolic process#GO:0009056;intracellular iron ion homeostasis#GO:0006879;intracellular monoatomic ion homeostasis#GO:0006873 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;outer membrane#GO:0019867;organelle outer membrane#GO:0031968;cytoplasm#GO:0005737;membrane#GO:0016020;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;mitochondrial outer membrane#GO:0005741;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090 HUMAN|HGNC=18070|UniProtKB=Q8WUX1 Q8WUX1 SLC38A5 PTHR22950:SF74 AMINO ACID TRANSPORTER SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 5 neutral L-amino acid transmembrane transporter activity#GO:0015175;transporter activity#GO:0005215;carboxylic acid transmembrane transporter activity#GO:0046943;transmembrane transporter activity#GO:0022857;amino acid transmembrane transporter activity#GO:0015171;L-amino acid transmembrane transporter activity#GO:0015179;glycine transmembrane transporter activity#GO:0015187 establishment of localization#GO:0051234;transmembrane transport#GO:0055085;amino acid transmembrane transport#GO:0003333;neutral amino acid transport#GO:0015804;localization#GO:0051179;amino acid transport#GO:0006865;organic acid transport#GO:0015849;transport#GO:0006810;carboxylic acid transport#GO:0046942;glycine transport#GO:0015816;carboxylic acid transmembrane transport#GO:1905039;cellular process#GO:0009987;nitrogen compound transport#GO:0071705;L-alpha-amino acid transmembrane transport#GO:1902475;L-amino acid transport#GO:0015807 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258;amino acid transporter#PC00046 HUMAN|HGNC=4173|UniProtKB=P43694 P43694 GATA4 PTHR10071:SF154 TRANSCRIPTION FACTOR GATA FAMILY MEMBER TRANSCRIPTION FACTOR GATA-4 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 positive regulation of macromolecule metabolic process#GO:0010604;negative regulation of macromolecule biosynthetic process#GO:0010558;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of transcription by RNA polymerase II#GO:0045944;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;negative regulation of DNA-templated transcription#GO:0045892;cell fate commitment#GO:0045165;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218 Gonadotropin-releasing hormone receptor pathway#P06664>GATA2/4#P06859 HUMAN|HGNC=1107|UniProtKB=Q07352 Q07352 ZFP36L1 PTHR12547:SF53 CCCH ZINC FINGER/TIS11-RELATED MRNA DECAY ACTIVATOR PROTEIN ZFP36L1 RNA binding#GO:0003723;mRNA binding#GO:0003729;protein-macromolecule adaptor activity#GO:0030674;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA 3'-UTR binding#GO:0003730;translation regulator activity#GO:0045182;molecular adaptor activity#GO:0060090;protein-RNA adaptor activity#GO:0140517 negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;regulation of mRNA stability#GO:0043488;RNA catabolic process#GO:0006401;positive regulation of metabolic process#GO:0009893;RNA metabolic process#GO:0016070;regulation of biological quality#GO:0065008;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;RNA destabilization#GO:0050779;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;metabolic process#GO:0008152;positive regulation of mRNA metabolic process#GO:1903313;mRNA destabilization#GO:0061157;macromolecule catabolic process#GO:0009057;regulation of mRNA metabolic process#GO:1903311;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;positive regulation of mRNA catabolic process#GO:0061014;catabolic process#GO:0009056;nuclear-transcribed mRNA poly(A) tail shortening#GO:0000289;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;regulation of RNA stability#GO:0043487;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;nucleic acid catabolic process#GO:0141188;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;macromolecule metabolic process#GO:0043170;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;positive regulation of catabolic process#GO:0009896;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031 HUMAN|HGNC=18966|UniProtKB=Q9Y600 Q9Y600 CSAD PTHR45677:SF16 GLUTAMATE DECARBOXYLASE-RELATED CYSTEINE SULFINIC ACID DECARBOXYLASE carboxy-lyase activity#GO:0016831;catalytic activity#GO:0003824;carbon-carbon lyase activity#GO:0016830;lyase activity#GO:0016829 cellular process#GO:0009987;metabolic process#GO:0008152;sulfur compound metabolic process#GO:0006790;biosynthetic process#GO:0009058 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 decarboxylase#PC00089;metabolite interconversion enzyme#PC00262 Gamma-aminobutyric acid synthesis#P04384>Glutamate decarboxylase#P04482 HUMAN|HGNC=8078|UniProtKB=O95158 O95158 NXPH4 PTHR17103:SF10 NEUREXOPHILIN NEUREXOPHILIN-4 binding#GO:0005488;signaling receptor binding#GO:0005102;protein binding#GO:0005515 regulation of signaling#GO:0023051;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of trans-synaptic signaling#GO:0099177;regulation of cell communication#GO:0010646;biological regulation#GO:0065007;modulation of chemical synaptic transmission#GO:0050804 cell junction#GO:0030054;synapse#GO:0045202;cellular anatomical structure#GO:0110165;GABA-ergic synapse#GO:0098982 intercellular signal molecule#PC00207 HUMAN|HGNC=12397|UniProtKB=Q15361 Q15361 TTF1 PTHR46760:SF1 TRANSCRIPTION TERMINATION FACTOR 1 TRANSCRIPTION TERMINATION FACTOR 1 General transcription regulation#P00023>TTF2#P00661;General transcription by RNA polymerase I#P00022>TTF-I#P00654;Transcription regulation by bZIP transcription factor#P00055>TTF2#P01389 HUMAN|HGNC=18142|UniProtKB=Q9Y4D1 Q9Y4D1 DAAM1 PTHR45725:SF16 FORMIN HOMOLOGY 2 FAMILY MEMBER DISHEVELED-ASSOCIATED ACTIVATOR OF MORPHOGENESIS 1 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;actin cytoskeleton#GO:0015629;actomyosin#GO:0042641;actin filament bundle#GO:0032432;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;stress fiber#GO:0001725;intracellular organelle#GO:0043229 HUMAN|HGNC=11333|UniProtKB=P31391 P31391 SSTR4 PTHR24229:SF35 NEUROPEPTIDES RECEPTOR SOMATOSTATIN RECEPTOR TYPE 4 molecular transducer activity#GO:0060089;binding#GO:0005488;neuropeptide receptor activity#GO:0008188;transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;neuropeptide binding#GO:0042923;peptide binding#GO:0042277;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023 response to lipid#GO:0033993;cellular response to lipid#GO:0071396;response to chemical#GO:0042221;biological regulation#GO:0065007;response to hormone#GO:0009725;cellular process#GO:0009987;signal transduction#GO:0007165;cellular response to steroid hormone stimulus#GO:0071383;regulation of cellular process#GO:0050794;cellular response to hormone stimulus#GO:0032870;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;signaling#GO:0023052;neuropeptide signaling pathway#GO:0007218;response to endogenous stimulus#GO:0009719;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cell communication#GO:0007154;response to steroid hormone#GO:0048545;G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887 cell projection#GO:0042995;plasma membrane#GO:0005886;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165;neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GsPCR#P00720;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GoPCR#P00725;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711 HUMAN|HGNC=17558|UniProtKB=O60294 O60294 LCMT2 PTHR46529:SF1 TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 4 TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 4 catalytic activity, acting on a tRNA#GO:0140101;methyltransferase activity#GO:0008168;tRNA methyltransferase activity#GO:0008175;RNA methyltransferase activity#GO:0008173;catalytic activity, acting on RNA#GO:0140098;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a nucleic acid#GO:0140640 RNA metabolic process#GO:0016070;methylation#GO:0032259;RNA methylation#GO:0001510;macromolecule modification#GO:0043412;macromolecule methylation#GO:0043414;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;RNA biosynthetic process#GO:0032774;tRNA modification#GO:0006400;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;tRNA methylation#GO:0030488;macromolecule biosynthetic process#GO:0009059 RNA metabolism protein#PC00031;RNA processing factor#PC00147 HUMAN|HGNC=11535|UniProtKB=P21675 P21675 TAF1 PTHR13900:SF1 TRANSCRIPTION INITIATION FACTOR TFIID TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1 protein binding#GO:0005515;binding#GO:0005488;transcription factor binding#GO:0008134 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;transcription initiation at RNA polymerase II promoter#GO:0006367;protein-DNA complex assembly#GO:0065004;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular component assembly#GO:0022607;transcription by RNA polymerase II#GO:0006366;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;protein-containing complex organization#GO:0043933;protein-DNA complex organization#GO:0071824;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-containing complex assembly#GO:0065003;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;RNA polymerase II preinitiation complex assembly#GO:0051123;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;DNA-templated transcription initiation#GO:0006352;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070 transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;transcription regulator complex#GO:0005667;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;RNA polymerase II transcription regulator complex#GO:0090575;membrane-enclosed lumen#GO:0031974;transcription factor TFIID complex#GO:0005669;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;membrane-bounded organelle#GO:0043227;RNA polymerase II, holoenzyme#GO:0016591;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226 general transcription factor#PC00259;RNA metabolism protein#PC00031 HUMAN|HGNC=15580|UniProtKB=Q5VU43 Q5VU43 PDE4DIP PTHR46501:SF2 MYOMEGALIN MYOMEGALIN microtubule-based process#GO:0007017;microtubule organizing center organization#GO:0031023;cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;cellular process#GO:0009987;organelle organization#GO:0006996;microtubule cytoskeleton organization#GO:0000226;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;cell cycle process#GO:0022402;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;centrosome cycle#GO:0007098;cellular component organization#GO:0016043;cell cycle#GO:0007049 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;microtubule cytoskeleton#GO:0015630;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;Golgi apparatus#GO:0005794;centrosome#GO:0005813;microtubule organizing center#GO:0005815 HUMAN|HGNC=29411|UniProtKB=Q14C87 Q14C87 TMEM132D PTHR13388:SF2 DETONATOR, ISOFORM E TRANSMEMBRANE PROTEIN 132D membrane#GO:0016020;cellular anatomical structure#GO:0110165 HUMAN|HGNC=13615|UniProtKB=Q9UF56 Q9UF56 FBXL17 PTHR16134:SF18 F-BOX/TPR REPEAT PROTEIN POF3 F-BOX_LRR-REPEAT PROTEIN 17 ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;response to external stimulus#GO:0009605;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;photoperiodism#GO:0009648;proteasomal protein catabolic process#GO:0010498;biological regulation#GO:0065007;response to radiation#GO:0009314;cellular process#GO:0009987;regulation of circadian rhythm#GO:0042752;protein metabolic process#GO:0019538;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;response to stimulus#GO:0050896;response to light stimulus#GO:0009416;catabolic process#GO:0009056;primary metabolic process#GO:0044238;response to abiotic stimulus#GO:0009628;regulation of biological process#GO:0050789;modification-dependent protein catabolic process#GO:0019941 catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ubiquitin ligase complex#GO:0000151;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;SCF ubiquitin ligase complex#GO:0019005;intracellular membrane-bounded organelle#GO:0043231;cullin-RING ubiquitin ligase complex#GO:0031461;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;cytosol#GO:0005829;nucleus#GO:0005634;protein-containing complex#GO:0032991;cytoplasm#GO:0005737 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=3382|UniProtKB=Q08495 Q08495 DMTN PTHR24213:SF17 ACTIN-BINDING LIM PROTEIN DEMATIN protein-containing complex binding#GO:0044877;protein binding#GO:0005515;actin filament binding#GO:0051015;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;binding#GO:0005488 cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection assembly#GO:0120031;cell projection organization#GO:0030030;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;cell projection assembly#GO:0030031;lamellipodium assembly#GO:0030032;cellular process#GO:0009987 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;actin cytoskeleton#GO:0015629;membrane#GO:0016020;cell periphery#GO:0071944 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=10909|UniProtKB=Q9NP59 Q9NP59 SLC40A1 PTHR11660:SF47 SOLUTE CARRIER FAMILY 40 MEMBER FERROPORTIN transition metal ion transmembrane transporter activity#GO:0046915;binding#GO:0005488;monoatomic cation transmembrane transporter activity#GO:0008324;iron ion transmembrane transporter activity#GO:0005381;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;hormone binding#GO:0042562;metal ion transmembrane transporter activity#GO:0046873;peptide hormone binding#GO:0017046;monoatomic ion transmembrane transporter activity#GO:0015075 iron ion transport#GO:0006826;iron ion transmembrane transport#GO:0034755;transition metal ion transport#GO:0000041;transport#GO:0006810;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;cellular process#GO:0009987;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220 plasma membrane#GO:0005886;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;basal plasma membrane#GO:0009925;cell periphery#GO:0071944;basal part of cell#GO:0045178;basolateral plasma membrane#GO:0016323;membrane#GO:0016020 secondary carrier transporter#PC00258;transporter#PC00227 HUMAN|HGNC=9523|UniProtKB=Q00889 Q00889 PSG6 PTHR44427:SF13 CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 19 PREGNANCY-SPECIFIC BETA-1-GLYCOPROTEIN 4-RELATED cell adhesion molecule#PC00069 HUMAN|HGNC=28509|UniProtKB=Q8NDZ0 Q8NDZ0 BEND2 PTHR47305:SF3 BEN DOMAIN-CONTAINING PROTEIN 2 BEN DOMAIN-CONTAINING PROTEIN 2 response to stimulus#GO:0050896;reproductive process#GO:0022414;cell cycle#GO:0007049;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular response to stimulus#GO:0051716;sexual reproduction#GO:0019953;cellular response to stress#GO:0033554;nucleobase-containing compound metabolic process#GO:0006139;response to stress#GO:0006950;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;double-strand break repair#GO:0006302;meiotic cell cycle#GO:0051321;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;DNA damage response#GO:0006974 intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;chromosome#GO:0005694;nucleus#GO:0005634;chromatin#GO:0000785;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=29366|UniProtKB=Q9C0D2 Q9C0D2 CEP295 PTHR21553:SF25 ALMS1-RELATED CENTROSOMAL PROTEIN OF 295 KDA regulation of microtubule-based process#GO:0032886;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of organelle assembly#GO:1902115;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of cellular component biogenesis#GO:0044087;biological regulation#GO:0065007;regulation of cell cycle process#GO:0010564;regulation of cell cycle#GO:0051726 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;centriole#GO:0005814;cytoplasm#GO:0005737;cytosol#GO:0005829;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;centrosome#GO:0005813;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 HUMAN|HGNC=29847|UniProtKB=O14513 O14513 NCKAP5 PTHR21740:SF0 NCK-ASSOCIATED PROTEIN 5 NCK-ASSOCIATED PROTEIN 5 protein depolymerization#GO:0051261;cytoskeleton organization#GO:0007010;protein-containing complex disassembly#GO:0032984;microtubule depolymerization#GO:0007019;cellular process#GO:0009987;cellular component organization#GO:0016043;microtubule polymerization or depolymerization#GO:0031109;organelle organization#GO:0006996;microtubule-based process#GO:0007017;protein-containing complex organization#GO:0043933;supramolecular fiber organization#GO:0097435;cellular component disassembly#GO:0022411;microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;microtubule bundle formation#GO:0001578 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;microtubule#GO:0005874;microtubule plus-end#GO:0035371;microtubule end#GO:1990752;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;organelle#GO:0043226;supramolecular complex#GO:0099080 HUMAN|HGNC=1742|UniProtKB=P50851 P50851 LRBA PTHR13743:SF64 BEIGE/BEACH-RELATED LIPOPOLYSACCHARIDE-RESPONSIVE AND BEIGE-LIKE ANCHOR PROTEIN enzyme binding#GO:0019899;protein kinase binding#GO:0019901;kinase binding#GO:0019900;binding#GO:0005488;protein binding#GO:0005515 catabolic process#GO:0009056;cell junction organization#GO:0034330;cellular component organization#GO:0016043;vacuole organization#GO:0007033;process utilizing autophagic mechanism#GO:0061919;localization#GO:0051179;synapse organization#GO:0050808;organelle assembly#GO:0070925;macroautophagy#GO:0016236;cellular component assembly#GO:0022607;autophagy#GO:0006914;autophagosome organization#GO:1905037;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;macromolecule localization#GO:0033036;intracellular protein localization#GO:0008104;autophagosome assembly#GO:0000045;cellular component organization or biogenesis#GO:0071840;mitophagy#GO:0000423;metabolic process#GO:0008152;autophagy of mitochondrion#GO:0000422 cytosol#GO:0005829;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=17909|UniProtKB=Q9BY84 Q9BY84 DUSP16 PTHR10159:SF343 DUAL SPECIFICITY PROTEIN PHOSPHATASE DUAL SPECIFICITY PROTEIN PHOSPHATASE 16 phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;protein tyrosine/serine/threonine phosphatase activity#GO:0008138;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096 cell communication#GO:0007154;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of cell communication#GO:0010646;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of MAPK cascade#GO:0043409;cellular response to stimulus#GO:0051716;negative regulation of cellular process#GO:0048523;regulation of MAPK cascade#GO:0043408;regulation of response to stimulus#GO:0048583;negative regulation of response to stimulus#GO:0048585;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;signal transduction#GO:0007165;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634 protein phosphatase#PC00195 Oxidative stress response#P00046>MKP5#P01131 HUMAN|HGNC=9564|UniProtKB=Q15008 Q15008 PSMD6 PTHR14145:SF1 26S PROTESOME SUBUNIT 6 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6 modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056 intracellular membrane-bounded organelle#GO:0043231;peptidase complex#GO:1905368;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;proteasome complex#GO:0000502;nucleus#GO:0005634;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endopeptidase complex#GO:1905369;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;proteasome regulatory particle, lid subcomplex#GO:0008541 Ubiquitin proteasome pathway#P00060>26S proteasome#P01489 HUMAN|HGNC=7381|UniProtKB=Q04912 Q04912 MST1R PTHR24416:SF564 TYROSINE-PROTEIN KINASE RECEPTOR MACROPHAGE-STIMULATING PROTEIN RECEPTOR transmembrane signaling receptor activity#GO:0004888;phosphotransferase activity, alcohol group as acceptor#GO:0016773;molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714;protein kinase activity#GO:0004672;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein tyrosine kinase activity#GO:0004713;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;signaling receptor activity#GO:0038023;transmembrane receptor protein kinase activity#GO:0019199 multicellular organismal process#GO:0032501;cell migration#GO:0016477;nervous system development#GO:0007399;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;establishment of localization#GO:0051234;import into cell#GO:0098657;multicellular organism development#GO:0007275;phagocytosis#GO:0006909;transport#GO:0006810;cell surface receptor signaling pathway#GO:0007166;developmental process#GO:0032502;cell motility#GO:0048870;endocytosis#GO:0006897;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;localization#GO:0051179;cell communication#GO:0007154;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169 signaling receptor complex#GO:0043235;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=25557|UniProtKB=Q9NVM4 Q9NVM4 PRMT7 PTHR11006:SF4 PROTEIN ARGININE N-METHYLTRANSFERASE PROTEIN ARGININE N-METHYLTRANSFERASE 7 histone methyltransferase activity#GO:0042054;N-methyltransferase activity#GO:0008170;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;histone modifying activity#GO:0140993;protein methyltransferase activity#GO:0008276;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a protein#GO:0140096 regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;chromatin remodeling#GO:0006338;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;chromatin organization#GO:0006325;regulation of nucleobase-containing compound metabolic process#GO:0019219 protein modifying enzyme#PC00260 HUMAN|HGNC=923|UniProtKB=O94766 O94766 B3GAT3 PTHR10896:SF73 GALACTOSYLGALACTOSYLXYLOSYLPROTEIN 3-BETA-GLUCURONOSYLTRANSFERASE BETA-1,3-GLUCURONYLTRANSFERASE GALACTOSYLGALACTOSYLXYLOSYLPROTEIN 3-BETA-GLUCURONOSYLTRANSFERASE 3 hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;glucuronosyltransferase activity#GO:0015020;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194 protein metabolic process#GO:0019538;carbohydrate metabolic process#GO:0005975;primary metabolic process#GO:0044238;proteoglycan metabolic process#GO:0006029;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;proteoglycan biosynthetic process#GO:0030166;biosynthetic process#GO:0009058;chondroitin sulfate proteoglycan biosynthetic process#GO:0050650;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;chondroitin sulfate proteoglycan metabolic process#GO:0050654;protein O-linked glycosylation#GO:0006493;glycoprotein biosynthetic process#GO:0009101 membrane-bounded organelle#GO:0043227;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;membrane#GO:0016020 glycosyltransferase#PC00111 HUMAN|HGNC=29822|UniProtKB=Q9Y6X6 Q9Y6X6 MYO16 PTHR47335:SF1 UNCONVENTIONAL MYOSIN-XVI UNCONVENTIONAL MYOSIN-XVI plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;cell projection morphogenesis#GO:0048858;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;signal transduction#GO:0007165;neuron projection development#GO:0031175;intracellular signaling cassette#GO:0141124;nervous system development#GO:0007399;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;neuron development#GO:0048666;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;cell development#GO:0048468;signaling#GO:0023052;cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;cell differentiation#GO:0030154;response to stimulus#GO:0050896;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0043491;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;intracellular signal transduction#GO:0035556;system development#GO:0048731;anatomical structure development#GO:0048856;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;actin cytoskeleton#GO:0015629;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;perinuclear region of cytoplasm#GO:0048471;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;myosin complex#GO:0016459;nucleus#GO:0005634 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HUMAN|HGNC=3246|UniProtKB=Q9NZC4 Q9NZC4 EHF PTHR11849:SF171 ETS ETS HOMOLOGOUS FACTOR DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700 regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;developmental process#GO:0032502;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 winged helix/forkhead transcription factor#PC00246;DNA-binding transcription factor#PC00218 PDGF signaling pathway#P00047>Ets#P01167 HUMAN|HGNC=4610|UniProtKB=Q12849 Q12849 GRSF1 PTHR13976:SF42 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED G-RICH SEQUENCE FACTOR 1 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA splicing#GO:0043484 organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 RNA splicing factor#PC00148;RNA metabolism protein#PC00031;RNA processing factor#PC00147 HUMAN|HGNC=28775|UniProtKB=Q9BVX2 Q9BVX2 TMEM106C PTHR28556:SF5 TRANSMEMBRANE PROTEIN 106B TRANSMEMBRANE PROTEIN 106C HUMAN|HGNC=6126|UniProtKB=Q9Y4H2 Q9Y4H2 IRS2 PTHR10614:SF7 INSULIN RECEPTOR SUBSTRATE INSULIN RECEPTOR SUBSTRATE 2 protein binding#GO:0005515;signaling adaptor activity#GO:0035591;protein kinase binding#GO:0019901;transmembrane receptor protein tyrosine kinase adaptor activity#GO:0005068;enzyme binding#GO:0019899;protein-macromolecule adaptor activity#GO:0030674;signaling receptor binding#GO:0005102;binding#GO:0005488;protein tyrosine kinase binding#GO:1990782;kinase binding#GO:0019900;receptor tyrosine kinase binding#GO:0030971;molecular adaptor activity#GO:0060090;signaling receptor complex adaptor activity#GO:0030159 cellular response to endogenous stimulus#GO:0071495;insulin-like growth factor receptor signaling pathway#GO:0048009;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cellular response to hormone stimulus#GO:0032870;signaling#GO:0023052;cellular response to peptide hormone stimulus#GO:0071375;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to insulin#GO:0032868;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;response to nitrogen compound#GO:1901698;intracellular signal transduction#GO:0035556;cellular response to chemical stimulus#GO:0070887;insulin receptor signaling pathway#GO:0008286;response to oxygen-containing compound#GO:1901700;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;response to chemical#GO:0042221;cellular response to nitrogen compound#GO:1901699;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124;response to peptide hormone#GO:0043434;response to hormone#GO:0009725;phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0043491;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987;cellular response to insulin stimulus#GO:0032869;cell surface receptor signaling pathway#GO:0007166 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;cytosol#GO:0005829 scaffold/adaptor protein#PC00226 Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>IRS 1-4#P00887;Gonadotropin-releasing hormone receptor pathway#P06664>IRS#P06759;Interleukin signaling pathway#P00036>IRS1/2#P00980;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>IRS 1-4#P00899 HUMAN|HGNC=8651|UniProtKB=P57721 P57721 PCBP3 PTHR10288:SF98 KH DOMAIN CONTAINING RNA BINDING PROTEIN POLY(RC)-BINDING PROTEIN 3 RNA binding#GO:0003723;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 RNA metabolism protein#PC00031 HUMAN|HGNC=29110|UniProtKB=Q2KHM9 Q2KHM9 KIAA0753 PTHR15732:SF4 PROTEIN MOONRAKER PROTEIN MOONRAKER intracellular protein localization#GO:0008104;protein localization to microtubule organizing center#GO:1905508;protein localization to microtubule cytoskeleton#GO:0072698;localization#GO:0051179;protein localization to organelle#GO:0033365;macromolecule localization#GO:0033036;protein localization to cytoskeleton#GO:0044380 microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 HUMAN|HGNC=3119|UniProtKB=Q15329 Q15329 E2F5 PTHR12081:SF35 TRANSCRIPTION FACTOR E2F TRANSCRIPTION FACTOR E2F5 DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634 helix-turn-helix transcription factor#PC00116;gene-specific transcriptional regulator#PC00264;winged helix/forkhead transcription factor#PC00246 HUMAN|HGNC=7825|UniProtKB=Q9NZG7 Q9NZG7 NINJ2 PTHR12316:SF24 NINJURIN-RELATED NINJURIN-2 cell-cell adhesion mediator activity#GO:0098632;protein binding#GO:0005515;cell adhesion mediator activity#GO:0098631;cell adhesion molecule binding#GO:0050839;binding#GO:0005488 cellular process#GO:0009987;cell death#GO:0008219;cell adhesion#GO:0007155;programmed cell death#GO:0012501 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 cell adhesion molecule#PC00069 HUMAN|HGNC=28213|UniProtKB=Q3MUY2 Q3MUY2 PIGY PTHR39235:SF1 PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Y PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Y molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;enzyme activator activity#GO:0008047 lipid metabolic process#GO:0006629;GPI anchor metabolic process#GO:0006505;glycerophospholipid biosynthetic process#GO:0046474;metabolic process#GO:0008152;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;organophosphate metabolic process#GO:0019637;biosynthetic process#GO:0009058;protein maturation#GO:0051604;lipid biosynthetic process#GO:0008610;gene expression#GO:0010467;glycerophospholipid metabolic process#GO:0006650;GPI anchor biosynthetic process#GO:0006506;protein metabolic process#GO:0019538;organophosphate biosynthetic process#GO:0090407;glycolipid biosynthetic process#GO:0009247;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;phospholipid metabolic process#GO:0006644;glycolipid metabolic process#GO:0006664;phospholipid biosynthetic process#GO:0008654;GPI anchored protein biosynthesis#GO:0180046;liposaccharide metabolic process#GO:1903509;glycerolipid metabolic process#GO:0046486 membrane#GO:0016020;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;endoplasmic reticulum membrane#GO:0005789;transferase complex#GO:1990234;endoplasmic reticulum#GO:0005783;endoplasmic reticulum protein-containing complex#GO:0140534;organelle membrane#GO:0031090;membrane protein complex#GO:0098796;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622 transferase#PC00220 HUMAN|HGNC=16804|UniProtKB=O00308 O00308 WWP2 PTHR11254:SF396 HECT DOMAIN UBIQUITIN-PROTEIN LIGASE NEDD4-LIKE E3 UBIQUITIN-PROTEIN LIGASE WWP2 ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;binding#GO:0005488;acyltransferase activity#GO:0016746;DNA-binding transcription factor binding#GO:0140297;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629;protein binding#GO:0005515;catalytic activity#GO:0003824;transferase activity#GO:0016740;transcription factor binding#GO:0008134;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 regulation of DNA-templated transcription#GO:0006355;protein metabolic process#GO:0019538;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;regulation of transmembrane transport#GO:0034762;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;regulation of gene expression#GO:0010468;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;negative regulation of cellular process#GO:0048523;regulation of monoatomic ion transport#GO:0043269;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of transport#GO:0051049;regulation of localization#GO:0032879;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;proteasomal protein catabolic process#GO:0010498;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;regulation of monoatomic ion transmembrane transport#GO:0034765 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Ubiquitin proteasome pathway#P00060>E3#P01490 HUMAN|HGNC=14697|UniProtKB=Q8NH37 Q8NH37 OR4C3 PTHR48002:SF40 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 4C3 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=26242|UniProtKB=Q6ZT98 Q6ZT98 TTLL7 PTHR12241:SF147 TUBULIN POLYGLUTAMYLASE TUBULIN POLYGLUTAMYLASE TTLL7 catalytic activity#GO:0003824;ligase activity#GO:0016874;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;catalytic activity, acting on a protein#GO:0140096;binding#GO:0005488;protein binding#GO:0005515;ligase activity, forming carbon-nitrogen bonds#GO:0016879 microtubule-based process#GO:0007017;cytoskeleton organization#GO:0007010;microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996 intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microtubule cytoskeleton#GO:0015630;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cilium#GO:0005929;microtubule organizing center#GO:0005815;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856 microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=24722|UniProtKB=Q8N883 Q8N883 ZNF614 PTHR24381:SF110 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 614 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=13281|UniProtKB=B1AK53 B1AK53 ESPN PTHR24153:SF14 ESPIN ESPIN binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;actin filament binding#GO:0051015;protein binding#GO:0005515;protein-containing complex binding#GO:0044877 cell projection organization#GO:0030030;actin cytoskeleton organization#GO:0030036;cellular component organization#GO:0016043;actin filament bundle assembly#GO:0051017;actin filament bundle organization#GO:0061572;supramolecular fiber organization#GO:0097435;actin filament-based process#GO:0030029;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection organization#GO:0120036;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;actin filament organization#GO:0007015;plasma membrane bounded cell projection assembly#GO:0120031 intracellular organelle#GO:0043229;stereocilium#GO:0032420;cytoskeleton#GO:0005856;cluster of actin-based cell projections#GO:0098862;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;neuron projection#GO:0043005;actin-based cell projection#GO:0098858;actin cytoskeleton#GO:0015629;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165 non-motor actin binding protein#PC00165;actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=17328|UniProtKB=Q96EV8 Q96EV8 DTNBP1 PTHR16294:SF5 DYSTROBREVIN BINDING PROTEIN 1 DYSBINDIN DYSBINDIN multicellular organismal process#GO:0032501;cytoskeleton-dependent intracellular transport#GO:0030705;biological regulation#GO:0065007;neurogenesis#GO:0022008;vesicle cytoskeletal trafficking#GO:0099518;intracellular transport#GO:0046907;vesicle transport along microtubule#GO:0047496;regulation of response to stimulus#GO:0048583;transport#GO:0006810;microtubule-based movement#GO:0007018;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;modulation of chemical synaptic transmission#GO:0050804;anatomical structure development#GO:0048856;regulation of exocytosis#GO:0017157;regulation of trans-synaptic signaling#GO:0099177;synaptic vesicle localization#GO:0097479;organelle transport along microtubule#GO:0072384;nervous system development#GO:0007399;endomembrane system organization#GO:0010256;synaptic vesicle transport#GO:0048489;neuron projection development#GO:0031175;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;neuron differentiation#GO:0030182;establishment of organelle localization#GO:0051656;regulation of synaptic vesicle exocytosis#GO:2000300;cell development#GO:0048468;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;cellular localization#GO:0051641;neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;regulation of neurotransmitter transport#GO:0051588;regulation of signaling#GO:0023051;microtubule-based transport#GO:0099111;plasma membrane bounded cell projection organization#GO:0120036;regulation of signal transduction#GO:0009966;axo-dendritic transport#GO:0008088;vesicle localization#GO:0051648;cellular developmental process#GO:0048869;transport along microtubule#GO:0010970;establishment of localization#GO:0051234;anterograde synaptic vesicle transport#GO:0048490;developmental process#GO:0032502;localization#GO:0051179;regulation of secretion#GO:0051046;anterograde axonal transport#GO:0008089;system development#GO:0048731;organelle localization#GO:0051640;axonal transport#GO:0098930;establishment of vesicle localization#GO:0051650;microtubule-based process#GO:0007017;vesicle organization#GO:0016050;regulation of transport#GO:0051049;regulation of localization#GO:0032879;regulation of neurotransmitter secretion#GO:0046928;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cellular component organization#GO:0016043;regulation of secretion by cell#GO:1903530;generation of neurons#GO:0048699 intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;BLOC-1 complex#GO:0031083;synaptic vesicle#GO:0008021;vesicle#GO:0031982;synaptic vesicle membrane#GO:0030672;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;organelle membrane#GO:0031090;intracellular protein-containing complex#GO:0140535;membrane#GO:0016020;vesicle membrane#GO:0012506;cell periphery#GO:0071944;endomembrane system#GO:0012505;transport vesicle membrane#GO:0030658;transport vesicle#GO:0030133;plasma membrane#GO:0005886;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;intracellular vesicle#GO:0097708;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cell projection#GO:0042995;cell junction#GO:0030054;bounding membrane of organelle#GO:0098588;secretory vesicle#GO:0099503;neuron projection#GO:0043005;presynapse#GO:0098793;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737 HUMAN|HGNC=14216|UniProtKB=Q9H2C1 Q9H2C1 LHX5 PTHR24208:SF115 LIM/HOMEOBOX PROTEIN LHX LIM_HOMEOBOX PROTEIN LHX5 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;neuron differentiation#GO:0030182;developmental process#GO:0032502;nervous system development#GO:0007399;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119 HUMAN|HGNC=9884|UniProtKB=P06400 P06400 RB1 PTHR13742:SF36 RETINOBLASTOMA-ASSOCIATED PROTEIN RB -RELATED RETINOBLASTOMA-ASSOCIATED PROTEIN double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 cellular component organization#GO:0016043;negative regulation of cell cycle phase transition#GO:1901988;negative regulation of biological process#GO:0048519;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cell morphogenesis#GO:0000902;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell development#GO:0048468;regulation of cell cycle#GO:0051726;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;regulation of G1/S transition of mitotic cell cycle#GO:2000045;regulation of mitotic cell cycle phase transition#GO:1901990;neuron development#GO:0048666;negative regulation of mitotic cell cycle#GO:0045930;neuron projection development#GO:0031175;cellular process#GO:0009987;negative regulation of mitotic cell cycle phase transition#GO:1901991;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;regulation of cell cycle process#GO:0010564;neuron differentiation#GO:0030182;cellular component organization or biogenesis#GO:0071840;negative regulation of cell cycle#GO:0045786;multicellular organism development#GO:0007275;regulation of cell cycle phase transition#GO:1901987;regulation of cellular process#GO:0050794;regulation of cell cycle G1/S phase transition#GO:1902806;anatomical structure development#GO:0048856;system development#GO:0048731;regulation of mitotic cell cycle#GO:0007346;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;negative regulation of cell cycle process#GO:0010948;developmental process#GO:0032502;cellular developmental process#GO:0048869;neurogenesis#GO:0022008 intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;chromosome#GO:0005694;RNA polymerase II transcription regulator complex#GO:0090575;chromatin#GO:0000785;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232 chromatin/chromatin-binding, or -regulatory protein#PC00077 p53 pathway feedback loops 2#P04398>Rb#P04654 HUMAN|HGNC=17759|UniProtKB=Q5T2R2 Q5T2R2 PDSS1 PTHR12001:SF78 GERANYLGERANYL PYROPHOSPHATE SYNTHASE ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS1 catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;prenyltransferase activity#GO:0004659 metabolic process#GO:0008152;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;isoprenoid biosynthetic process#GO:0008299;isoprenoid metabolic process#GO:0006720;ketone metabolic process#GO:0042180;primary metabolic process#GO:0044238;ubiquinone biosynthetic process#GO:0006744;cellular process#GO:0009987;ketone biosynthetic process#GO:0042181;small molecule metabolic process#GO:0044281;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex#GO:1990234;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739 metabolite interconversion enzyme#PC00262 Cholesterol biosynthesis#P00014>Dimethylallyl trans-transferase#P00490 HUMAN|HGNC=6903|UniProtKB=Q00266 Q00266 MAT1A PTHR11964:SF11 S-ADENOSYLMETHIONINE SYNTHETASE S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-1 transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;transferase activity#GO:0016740;catalytic activity#GO:0003824 cellular process#GO:0009987;metabolic process#GO:0008152;sulfur compound metabolic process#GO:0006790;biosynthetic process#GO:0009058 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 nucleotidyltransferase#PC00174;transferase#PC00220 S-adenosylmethionine biosynthesis#P02773>S-Adenosyl methionine synthetase#P03143 HUMAN|HGNC=21367|UniProtKB=Q8N884 Q8N884 CGAS PTHR10656:SF35 CELL FATE DETERMINING PROTEIN MAB21-RELATED CYCLIC GMP-AMP SYNTHASE DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;binding#GO:0005488;chromatin binding#GO:0003682;catalytic activity#GO:0003824;transferase activity#GO:0016740;nucleotidyltransferase activity#GO:0016779;transferase activity, transferring phosphorus-containing groups#GO:0016772 regulation of immune response#GO:0050776;regulation of defense response#GO:0031347;regulation of double-strand break repair#GO:2000779;negative regulation of DNA recombination#GO:0045910;positive regulation of type I interferon production#GO:0032481;cellular response to stimulus#GO:0051716;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;negative regulation of cellular process#GO:0048523;DNA damage response#GO:0006974;positive regulation of immune response#GO:0050778;positive regulation of defense response#GO:0031349;regulation of response to stimulus#GO:0048583;regulation of DNA repair#GO:0006282;regulation of innate immune response#GO:0045088;regulation of biosynthetic process#GO:0009889;positive regulation of response to biotic stimulus#GO:0002833;regulation of cytokine production#GO:0001817;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of response to stimulus#GO:0048584;negative regulation of response to stimulus#GO:0048585;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;cellular response to chemical stimulus#GO:0070887;immune system process#GO:0002376;positive regulation of macromolecule biosynthetic process#GO:0010557;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;positive regulation of multicellular organismal process#GO:0051240;response to stimulus#GO:0050896;positive regulation of immune system process#GO:0002684;activation of immune response#GO:0002253;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;regulation of response to external stimulus#GO:0032101;positive regulation of biosynthetic process#GO:0009891;cell communication#GO:0007154;response to nitrogen compound#GO:1901698;positive regulation of cytokine production#GO:0001819;regulation of response to biotic stimulus#GO:0002831;regulation of response to stress#GO:0080134;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;activation of innate immune response#GO:0002218;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of innate immune response#GO:0045089;cellular response to nitrogen compound#GO:1901699;negative regulation of DNA metabolic process#GO:0051053;regulation of DNA recombination#GO:0000018;cellular response to stress#GO:0033554;positive regulation of metabolic process#GO:0009893;regulation of cellular response to stress#GO:0080135;regulation of DNA metabolic process#GO:0051052;regulation of double-strand break repair via homologous recombination#GO:0010569;signaling#GO:0023052;negative regulation of metabolic process#GO:0009892;negative regulation of double-strand break repair via homologous recombination#GO:2000042;positive regulation of response to external stimulus#GO:0032103;response to stress#GO:0006950;response to chemical#GO:0042221;regulation of multicellular organismal process#GO:0051239 intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;site of DNA damage#GO:0090734;site of double-strand break#GO:0035861;chromosome#GO:0005694;cytosol#GO:0005829;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232 transferase#PC00220;nucleotidyltransferase#PC00174 HUMAN|HGNC=13469|UniProtKB=O75509 O75509 TNFRSF21 PTHR46921:SF1 TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 21 TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 21 regulation of cell population proliferation#GO:0042127;regulation of nervous system development#GO:0051960;negative regulation of T cell activation#GO:0050868;negative regulation of leukocyte cell-cell adhesion#GO:1903038;regulation of developmental process#GO:0050793;regulation of T cell proliferation#GO:0042129;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of cell-cell adhesion#GO:0022407;cell death#GO:0008219;negative regulation of multicellular organismal process#GO:0051241;programmed cell death#GO:0012501;negative regulation of cell activation#GO:0050866;regulation of leukocyte cell-cell adhesion#GO:1903037;regulation of system process#GO:0044057;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;negative regulation of immune system process#GO:0002683;adaptive immune response#GO:0002250;negative regulation of cell adhesion#GO:0007162;regulation of cell adhesion#GO:0030155;regulation of lymphocyte proliferation#GO:0050670;immune response#GO:0006955;negative regulation of cell population proliferation#GO:0008285;neuron apoptotic process#GO:0051402;immune system process#GO:0002376;regulation of lymphocyte activation#GO:0051249;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;regulation of cell activation#GO:0050865;regulation of multicellular organismal development#GO:2000026;apoptotic process#GO:0006915;regulation of leukocyte activation#GO:0002694;negative regulation of biological process#GO:0048519;negative regulation of T cell proliferation#GO:0042130;regulation of leukocyte proliferation#GO:0070663;humoral immune response#GO:0006959;regulation of B cell proliferation#GO:0030888;negative regulation of leukocyte activation#GO:0002695;negative regulation of lymphocyte activation#GO:0051250;regulation of multicellular organismal process#GO:0051239;negative regulation of cell-cell adhesion#GO:0022408;regulation of T cell activation#GO:0050863;cellular process#GO:0009987;regulation of B cell activation#GO:0050864;regulation of mononuclear cell proliferation#GO:0032944 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=25714|UniProtKB=Q96ER9 Q96ER9 CCDC51 PTHR28624:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 51 MITOCHONDRIAL POTASSIUM CHANNEL HUMAN|HGNC=18163|UniProtKB=Q86WN2 Q86WN2 IFNE PTHR11691:SF8 TYPE I INTERFERON INTERFERON EPSILON signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;cytokine activity#GO:0005125;signaling receptor binding#GO:0005102;binding#GO:0005488;cytokine receptor binding#GO:0005126;molecular function activator activity#GO:0140677;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 response to external stimulus#GO:0009605;defense response#GO:0006952;innate immune response#GO:0045087;biological regulation#GO:0065007;adaptive immune response#GO:0002250;response to other organism#GO:0051707;multicellular organismal process#GO:0032501;immune response#GO:0006955;response to nitrogen compound#GO:1901698;cell communication#GO:0007154;cell activation#GO:0001775;cytokine-mediated signaling pathway#GO:0019221;response to external biotic stimulus#GO:0043207;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;leukocyte activation#GO:0045321;B cell activation#GO:0042113;leukocyte activation involved in immune response#GO:0002366;natural killer cell activation#GO:0030101;cell surface receptor signaling pathway#GO:0007166;immune effector process#GO:0002252;humoral immune response#GO:0006959;T cell activation involved in immune response#GO:0002286;response to cytokine#GO:0034097;lymphocyte activation#GO:0046649;response to chemical#GO:0042221;defense response to other organism#GO:0098542;signal transduction#GO:0007165;defense response to symbiont#GO:0140546;lymphocyte activation involved in immune response#GO:0002285;cellular process#GO:0009987;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;cell activation involved in immune response#GO:0002263;response to peptide#GO:1901652;immune system process#GO:0002376;type I interferon-mediated signaling pathway#GO:0060337;B cell activation involved in immune response#GO:0002312;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;T cell activation#GO:0042110 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 interferon superfamily#PC00127;cytokine#PC00083 HUMAN|HGNC=28702|UniProtKB=Q8N4Z0 Q8N4Z0 RAB42 PTHR24070:SF17 RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY RAS-RELATED PROTEIN RAB-42 hydrolase activity, acting on acid anhydrides#GO:0016817;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787 Ras protein signal transduction#GO:0007265;establishment or maintenance of cell polarity#GO:0007163;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;biological regulation#GO:0065007;signaling#GO:0023052;small GTPase-mediated signal transduction#GO:0007264;intracellular signaling cassette#GO:0141124;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 small GTPase#PC00208 TGF-beta signaling pathway#P00052>Ras-GTP#P01280;Integrin signalling pathway#P00034>Ras#P00916;Ras Pathway#P04393>Ras#P04547;TGF-beta signaling pathway#P00052>Ras-GDP#P01291;EGF receptor signaling pathway#P00018>Ras#P00552;PDGF signaling pathway#P00047>Ras#P01154;p53 pathway feedback loops 2#P04398>Ras#P04651;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Ras#P00869;FGF signaling pathway#P00021>Ras#P00633;PI3 kinase pathway#P00048>Ras#P01182 HUMAN|HGNC=24624|UniProtKB=Q9H173 Q9H173 SIL1 PTHR19316:SF35 PROTEIN FOLDING REGULATOR NUCLEOTIDE EXCHANGE FACTOR SIL1 molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=26446|UniProtKB=Q6PI47 Q6PI47 KCTD18 PTHR14499:SF4 POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD18 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 scaffold/adaptor protein#PC00226 HUMAN|HGNC=9803|UniProtKB=P60763 P60763 RAC3 PTHR24072:SF325 RHO FAMILY GTPASE RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3 protein kinase binding#GO:0019901;enzyme binding#GO:0019899;guanyl nucleotide binding#GO:0019001;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;kinase binding#GO:0019900;binding#GO:0005488;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;protein binding#GO:0005515;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;ion binding#GO:0043167;GTPase activity#GO:0003924;small molecule binding#GO:0036094;anion binding#GO:0043168;hydrolase activity#GO:0016787;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111 cortical cytoskeleton organization#GO:0030865;supramolecular fiber organization#GO:0097435;system development#GO:0048731;intracellular signal transduction#GO:0035556;regulation of cell motility#GO:2000145;cell communication#GO:0007154;regulation of developmental process#GO:0050793;regulation of cytoskeleton organization#GO:0051493;actin cytoskeleton organization#GO:0030036;developmental process#GO:0032502;regulation of actin filament-based process#GO:0032970;cellular developmental process#GO:0048869;axon development#GO:0061564;plasma membrane bounded cell projection organization#GO:0120036;generation of neurons#GO:0048699;establishment or maintenance of cell polarity#GO:0007163;Rac protein signal transduction#GO:0016601;motor neuron axon guidance#GO:0008045;cellular component organization#GO:0016043;signaling#GO:0023052;cell projection organization#GO:0030030;cell differentiation#GO:0030154;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell projection morphogenesis#GO:0048858;cytoskeleton organization#GO:0007010;regulation of actin cytoskeleton organization#GO:0032956;cellular component assembly#GO:0022607;actin filament-based process#GO:0030029;anatomical structure development#GO:0048856;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;regulation of cell migration#GO:0030334;neuron projection morphogenesis#GO:0048812;neuron projection guidance#GO:0097485;actin filament organization#GO:0007015;neurogenesis#GO:0022008;axon guidance#GO:0007411;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;multicellular organismal process#GO:0032501;animal gross anatomical part developmental process#GO:0160108;regulation of biological quality#GO:0065008;axonogenesis#GO:0007409;neuron development#GO:0048666;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;regulation of cell shape#GO:0008360;regulation of organelle organization#GO:0033043;cell development#GO:0048468;response to stimulus#GO:0050896;regulation of cellular component organization#GO:0051128;cell morphogenesis#GO:0000902;neuron differentiation#GO:0030182;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;regulation of anatomical structure morphogenesis#GO:0022603;cell projection assembly#GO:0030031;signal transduction#GO:0007165;cellular process#GO:0009987;neuron projection development#GO:0031175;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;intracellular signaling cassette#GO:0141124 cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;cell projection#GO:0042995;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856 G-protein#PC00020;small GTPase#PC00208 EGF receptor signaling pathway#P00018>Rac#P00564;T cell activation#P00053>rac#P01324;Ras Pathway#P04393>Rac#P04559;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Cdc42#P00834;Integrin signalling pathway#P00034>Rac#P00927;Huntington disease#P00029>Rac#P00775;FGF signaling pathway#P00021>Rac#P00645;Axon guidance mediated by netrin#P00009>Rac#P00366;Axon guidance mediated by semaphorins#P00007>Rac#P00340;Cytoskeletal regulation by Rho GTPase#P00016>Rac#P00523;VEGF signaling pathway#P00056>Rac#P01421;B cell activation#P00010>Rac#P00385;p38 MAPK pathway#P05918>Rac#P06021;Axon guidance mediated by Slit/Robo#P00008>Rac#P00354 HUMAN|HGNC=24824|UniProtKB=Q9UM11 Q9UM11 FZR1 PTHR19918:SF1 CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED FIZZY-RELATED PROTEIN HOMOLOG protein-containing complex binding#GO:0044877;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;binding#GO:0005488;enzyme activator activity#GO:0008047 macromolecule metabolic process#GO:0043170;positive regulation of catabolic process#GO:0009896;ubiquitin-dependent protein catabolic process#GO:0006511;regulation of catabolic process#GO:0009894;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434;protein metabolic process#GO:0019538;positive regulation of protein catabolic process#GO:0045732;regulation of protein catabolic process#GO:0042176;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;positive regulation of ubiquitin-dependent protein catabolic process#GO:2000060;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;regulation of proteasomal protein catabolic process#GO:0061136;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032436;proteasomal protein catabolic process#GO:0010498;regulation of protein metabolic process#GO:0051246;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of metabolic process#GO:0009893;protein catabolic process#GO:0030163;anaphase-promoting complex-dependent catabolic process#GO:0031145;positive regulation of protein metabolic process#GO:0051247;modification-dependent macromolecule catabolic process#GO:0043632;positive regulation of proteasomal protein catabolic process#GO:1901800;regulation of biological process#GO:0050789 ubiquitin ligase complex#GO:0000151;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;organelle#GO:0043226;nuclear ubiquitin ligase complex#GO:0000152;cellular anatomical structure#GO:0110165;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular membrane-bounded organelle#GO:0043231;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;protein-containing complex#GO:0032991;anaphase-promoting complex#GO:0005680;nucleus#GO:0005634 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=20842|UniProtKB=Q8IVH2 Q8IVH2 FOXP4 PTHR45796:SF7 FORKHEAD BOX P, ISOFORM C FORKHEAD BOX PROTEIN P4 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulator activity#GO:0140110;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription repressor activity#GO:0001217;sequence-specific DNA binding#GO:0043565 regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246 HUMAN|HGNC=21343|UniProtKB=Q86XW9 Q86XW9 NME9 PTHR46135:SF1 NME/NM23 FAMILY MEMBER 8 THIOREDOXIN DOMAIN-CONTAINING PROTEIN 6 HUMAN|HGNC=1260|UniProtKB=O43822 O43822 CFAP410 PTHR18849:SF0 LEUCINE RICH REPEAT PROTEIN CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 410 HUMAN|HGNC=23699|UniProtKB=Q8NHS0 Q8NHS0 DNAJB8 PTHR43948:SF9 DNAJ HOMOLOG SUBFAMILY B DNAJ HOMOLOG SUBFAMILY B MEMBER 8 protein-folding chaperone binding#GO:0051087;binding#GO:0005488;protein binding#GO:0005515 metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;protein maturation#GO:0051604;protein folding#GO:0006457;biosynthetic process#GO:0009058 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 chaperone#PC00072 HUMAN|HGNC=8174|UniProtKB=O60404 O60404 OR10H3 PTHR26453:SF705 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 10H3 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;detection of chemical stimulus#GO:0009593;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;response to chemical#GO:0042221;response to stimulus#GO:0050896;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;nervous system process#GO:0050877;sensory perception#GO:0007600;system process#GO:0003008 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=5821|UniProtKB=A0A075B6H7 A0A075B6H7 IGKV3-7 PTHR23267:SF331 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN KAPPA VARIABLE 3-15-RELATED response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=29393|UniProtKB=Q96Q06 Q96Q06 PLIN4 PTHR47538:SF1 PERILIPIN 4 PERILIPIN-4 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HUMAN|HGNC=4017|UniProtKB=P51993 P51993 FUT6 PTHR11929:SF227 ALPHA- 1,3 -FUCOSYLTRANSFERASE 4-GALACTOSYL-N-ACETYLGLUCOSAMINIDE 3-ALPHA-L-FUCOSYLTRANSFERASE FUT6 glycosyltransferase activity#GO:0016757;alpha-(1->3)-fucosyltransferase activity#GO:0046920;catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758;fucosyltransferase activity#GO:0008417 glycosyltransferase#PC00111 HUMAN|HGNC=25782|UniProtKB=Q9BTE3 Q9BTE3 MCMBP PTHR13489:SF0 MINI-CHROMOSOME MAINTENANCE COMPLEX-BINDING PROTEIN MINI-CHROMOSOME MAINTENANCE COMPLEX-BINDING PROTEIN binding#GO:0005488;chromatin binding#GO:0003682 cellular process#GO:0009987;DNA replication#GO:0006260;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;nucleobase-containing compound metabolic process#GO:0006139;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA-templated DNA replication#GO:0006261;macromolecule metabolic process#GO:0043170 HUMAN|HGNC=813|UniProtKB=Q93084 Q93084 ATP2A3 PTHR42861:SF6 CALCIUM-TRANSPORTING ATPASE SARCOPLASMIC_ENDOPLASMIC RETICULUM CALCIUM ATPASE 3 ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;P-type ion transporter activity#GO:0015662;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804 cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;chemical homeostasis#GO:0048878;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;intracellular calcium ion homeostasis#GO:0006874;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;calcium ion transport#GO:0006816;establishment of localization#GO:0051234;calcium ion transmembrane transport#GO:0070588;intracellular monoatomic ion homeostasis#GO:0006873;homeostatic process#GO:0042592;metal ion transport#GO:0030001;inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085 cellular anatomical structure#GO:0110165;membrane#GO:0016020 primary active transporter#PC00068 HUMAN|HGNC=33631|UniProtKB=Q5VY43 Q5VY43 PEAR1 PTHR24052:SF12 DELTA-RELATED PLATELET ENDOTHELIAL AGGREGATION RECEPTOR 1 cellular anatomical structure#GO:0110165;membrane#GO:0016020 membrane-bound signaling molecule#PC00152;intercellular signal molecule#PC00207 HUMAN|HGNC=28392|UniProtKB=Q6UWM5 Q6UWM5 GLIPR1L1 PTHR10334:SF220 CYSTEINE-RICH SECRETORY PROTEIN-RELATED GLIPR1-LIKE PROTEIN 1 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090 HUMAN|HGNC=8370|UniProtKB=Q8NGA2 Q8NGA2 OR7A2P PTHR48001:SF155 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 7A2-RELATED transmembrane signal receptor#PC00197 HUMAN|HGNC=14969|UniProtKB=Q9Y5X3 Q9Y5X3 SNX5 PTHR45850:SF5 SORTING NEXIN FAMILY MEMBER SORTING NEXIN-5 ion binding#GO:0043167;binding#GO:0005488;phosphatidylinositol binding#GO:0035091;anion binding#GO:0043168;small molecule binding#GO:0036094;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515 vesicle-mediated transport#GO:0016192;endocytosis#GO:0006897;cytosolic transport#GO:0016482;retrograde transport, endosome to Golgi#GO:0042147;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;cellular localization#GO:0051641;import into cell#GO:0098657;establishment of localization#GO:0051234;localization#GO:0051179;endosomal transport#GO:0016197;intracellular transport#GO:0046907;transport#GO:0006810 intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 scaffold/adaptor protein#PC00226 HUMAN|HGNC=6603|UniProtKB=Q8N149 Q8N149 LILRA2 PTHR11738:SF86 MHC CLASS I NK CELL RECEPTOR LEUKOCYTE IMMUNOGLOBULIN-LIKE RECEPTOR SUBFAMILY A MEMBER 2 molecular transducer activity#GO:0060089;immune receptor activity#GO:0140375;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;immune response-regulating signaling pathway#GO:0002764;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;signaling#GO:0023052;cytokine-mediated signaling pathway#GO:0019221;regulation of immune response#GO:0050776;cell communication#GO:0007154;response to peptide#GO:1901652;signal transduction#GO:0007165;cellular process#GO:0009987;response to chemical#GO:0042221;response to cytokine#GO:0034097;immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007;regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=15967|UniProtKB=P81534 P81534 DEFB103A PTHR20515:SF0 BETA-DEFENSIN BETA-DEFENSIN 103 molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;G protein-coupled receptor binding#GO:0001664;protein binding#GO:0005515;chemokine receptor binding#GO:0042379;molecular function activator activity#GO:0140677;signaling receptor binding#GO:0005102;cytokine receptor binding#GO:0005126;binding#GO:0005488 cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;cell motility#GO:0048870;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;locomotion#GO:0040011;cellular response to chemical stimulus#GO:0070887;response to bacterium#GO:0009617;chemotaxis#GO:0006935;defense response to bacterium#GO:0042742;cell chemotaxis#GO:0060326;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;cellular process#GO:0009987;response to chemical#GO:0042221;taxis#GO:0042330;cell migration#GO:0016477;response to other organism#GO:0051707;response to external stimulus#GO:0009605;defense response#GO:0006952 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090;antimicrobial response protein#PC00051 HUMAN|HGNC=11700|UniProtKB=Q13569 Q13569 TDG PTHR12159:SF9 G/T AND G/U MISMATCH-SPECIFIC DNA GLYCOSYLASE G_T MISMATCH-SPECIFIC THYMINE DNA GLYCOSYLASE catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;DNA N-glycosylase activity#GO:0019104;hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;catalytic activity, acting on DNA#GO:0140097 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;base-excision repair#GO:0006284;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;nucleobase-containing compound metabolic process#GO:0006139;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA metabolism protein#PC00009;DNA glycosylase#PC00010 HUMAN|HGNC=20824|UniProtKB=Q86WK6 Q86WK6 AMIGO1 PTHR24368:SF1 AMPHOTERIN-INDUCED PROTEIN AMPHOTERIN-INDUCED PROTEIN 1 transporter regulator activity#GO:0141108;potassium channel regulator activity#GO:0015459;ion channel regulator activity#GO:0099106;channel regulator activity#GO:0016247;molecular function regulator activity#GO:0098772 cell adhesion#GO:0007155;developmental process#GO:0032502;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;multicellular organism development#GO:0007275;anatomical structure development#GO:0048856;animal organ development#GO:0048513;cellular process#GO:0009987;heterophilic cell-cell adhesion#GO:0007157;cell-cell adhesion#GO:0098609;nervous system development#GO:0007399;head development#GO:0060322;brain development#GO:0007420;central nervous system development#GO:0007417;multicellular organismal process#GO:0032501 cation channel complex#GO:0034703;voltage-gated potassium channel complex#GO:0008076;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;membrane protein complex#GO:0098796;membrane#GO:0016020;cell body#GO:0044297;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;neuronal cell body#GO:0043025;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886 HUMAN|HGNC=16876|UniProtKB=Q9HBZ2 Q9HBZ2 ARNT2 PTHR23042:SF6 CIRCADIAN PROTEIN CLOCK/ARNT/BMAL/PAS ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR 2 binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;signaling receptor complex#GO:0043235;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231 basic helix-loop-helix transcription factor#PC00055;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=13621|UniProtKB=Q9H2J7 Q9H2J7 SLC6A15 PTHR11616:SF101 SODIUM/CHLORIDE DEPENDENT TRANSPORTER SODIUM-DEPENDENT NEUTRAL AMINO ACID TRANSPORTER B(0)AT2 monoatomic cation transmembrane transporter activity#GO:0008324;amino acid:sodium symporter activity#GO:0005283;solute:sodium symporter activity#GO:0015370;symporter activity#GO:0015293;carboxylic acid transmembrane transporter activity#GO:0046943;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;solute:monoatomic cation symporter activity#GO:0015294;monoatomic ion transmembrane transporter activity#GO:0015075;secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;amino acid transmembrane transporter activity#GO:0015171 monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;nitrogen compound transport#GO:0071705;L-amino acid transport#GO:0015807;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;establishment of localization#GO:0051234;branched-chain amino acid transport#GO:0015803;amino acid transport#GO:0006865;transport#GO:0006810;organic acid transport#GO:0015849;carboxylic acid transport#GO:0046942;L-leucine transport#GO:0015820;metal ion transport#GO:0030001;sodium ion transport#GO:0006814;transmembrane transport#GO:0055085;neutral amino acid transport#GO:0015804;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 primary active transporter#PC00068 Adrenaline and noradrenaline biosynthesis#P00001>amine translocator#P00068 HUMAN|HGNC=3037|UniProtKB=Q14574 Q14574 DSC3 PTHR24025:SF12 DESMOGLEIN FAMILY MEMBER DESMOCOLLIN-3 cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 cell adhesion#GO:0007155;cellular process#GO:0009987;cell-cell adhesion#GO:0098609 cell-cell junction#GO:0005911;cell junction#GO:0030054;cellular anatomical structure#GO:0110165;anchoring junction#GO:0070161 cadherin#PC00057 HUMAN|HGNC=10461|UniProtKB=P30622 P30622 CLIP1 PTHR18916:SF44 DYNACTIN 1-RELATED MICROTUBULE-BINDING CAP-GLY DOMAIN-CONTAINING LINKER PROTEIN 1 protein binding#GO:0005515;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;microtubule binding#GO:0008017 regulation of microtubule-based process#GO:0032886;positive regulation of cellular component organization#GO:0051130;positive regulation of organelle organization#GO:0010638;microtubule cytoskeleton organization#GO:0000226;supramolecular fiber organization#GO:0097435;regulation of microtubule polymerization#GO:0031113;cellular component organization#GO:0016043;regulation of protein-containing complex assembly#GO:0043254;regulation of biological process#GO:0050789;regulation of supramolecular fiber organization#GO:1902903;regulation of organelle organization#GO:0033043;regulation of protein polymerization#GO:0032271;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;cytoplasmic microtubule organization#GO:0031122;regulation of cellular process#GO:0050794;regulation of cellular component biogenesis#GO:0044087;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;regulation of microtubule polymerization or depolymerization#GO:0031110;organelle organization#GO:0006996;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;positive regulation of protein polymerization#GO:0032273;positive regulation of cellular component biogenesis#GO:0044089;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;regulation of microtubule cytoskeleton organization#GO:0070507 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;cell cortex#GO:0005938;microtubule end#GO:1990752;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoskeleton#GO:0005856;microtubule plus-end#GO:0035371;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;cell periphery#GO:0071944;nucleus#GO:0005634;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081 chaperone#PC00072 HUMAN|HGNC=23082|UniProtKB=Q6NTF9 Q6NTF9 RHBDD2 PTHR11009:SF31 DER1-LIKE PROTEIN, DERLIN RHOMBOID DOMAIN-CONTAINING PROTEIN 2 cellular process#GO:0009987;signal transduction#GO:0007165;response to stress#GO:0006950;endoplasmic reticulum unfolded protein response#GO:0030968;proteasomal protein catabolic process#GO:0010498;biological regulation#GO:0065007;response to chemical#GO:0042221;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;primary metabolic process#GO:0044238;signaling#GO:0023052;response to topologically incorrect protein#GO:0035966;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;catabolic process#GO:0009056;cellular response to topologically incorrect protein#GO:0035967;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;cellular response to unfolded protein#GO:0034620;response to endoplasmic reticulum stress#GO:0034976;intracellular signal transduction#GO:0035556;ERAD pathway#GO:0036503;protein metabolic process#GO:0019538;cell communication#GO:0007154;response to unfolded protein#GO:0006986 organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum membrane#GO:0005789;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane#GO:0016020 transporter#PC00227;primary active transporter#PC00068 HUMAN|HGNC=18717|UniProtKB=P08910 P08910 ABHD2 PTHR10794:SF45 ABHYDROLASE DOMAIN-CONTAINING PROTEIN MONOACYLGLYCEROL LIPASE ABHD2 hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;carboxylic ester hydrolase activity#GO:0052689 metabolic process#GO:0008152;acylglycerol catabolic process#GO:0046464;response to hormone#GO:0009725;sperm capacitation#GO:0048240;response to chemical#GO:0042221;response to lipid#GO:0033993;oxoacid metabolic process#GO:0043436;glycerolipid catabolic process#GO:0046503;spermatid differentiation#GO:0048515;hormone-mediated signaling pathway#GO:0009755;response to endogenous stimulus#GO:0009719;carboxylic acid metabolic process#GO:0019752;signaling#GO:0023052;small molecule metabolic process#GO:0044281;cellular response to endogenous stimulus#GO:0071495;cell differentiation#GO:0030154;glycerolipid metabolic process#GO:0046486;gamete generation#GO:0007276;spermatogenesis#GO:0007283;developmental process#GO:0032502;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;neutral lipid metabolic process#GO:0006638;cellular developmental process#GO:0048869;carboxylic acid catabolic process#GO:0046395;fatty acid biosynthetic process#GO:0006633;male gamete generation#GO:0048232;cell communication#GO:0007154;carboxylic acid biosynthetic process#GO:0046394;developmental process involved in reproduction#GO:0003006;reproductive process#GO:0022414;catabolic process#GO:0009056;cellular response to steroid hormone stimulus#GO:0071383;signal transduction#GO:0007165;lipid catabolic process#GO:0016042;cellular process#GO:0009987;cellular response to lipid#GO:0071396;cellular response to chemical stimulus#GO:0070887;fatty acid catabolic process#GO:0009062;regulation of biological process#GO:0050789;monocarboxylic acid metabolic process#GO:0032787;cellular process involved in reproduction in multicellular organism#GO:0022412;small molecule catabolic process#GO:0044282;cell development#GO:0048468;response to stimulus#GO:0050896;cellular response to hormone stimulus#GO:0032870;neutral lipid catabolic process#GO:0046461;acylglycerol metabolic process#GO:0006639;fatty acid metabolic process#GO:0006631;cell maturation#GO:0048469;monocarboxylic acid biosynthetic process#GO:0072330;biological regulation#GO:0065007;biosynthetic process#GO:0009058;developmental maturation#GO:0021700;lipid biosynthetic process#GO:0008610;monocarboxylic acid catabolic process#GO:0072329;sexual reproduction#GO:0019953;spermatid development#GO:0007286;response to steroid hormone#GO:0048545;multicellular organismal reproductive process#GO:0048609;anatomical structure development#GO:0048856;anatomical structure maturation#GO:0071695;steroid hormone receptor signaling pathway#GO:0043401;cellular response to stimulus#GO:0051716;germ cell development#GO:0007281;primary metabolic process#GO:0044238;regulation of cellular process#GO:0050794 cilium#GO:0005929;9+2 motile cilium#GO:0097729;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;cell periphery#GO:0071944;motile cilium#GO:0031514;organelle#GO:0043226;sperm flagellum#GO:0036126;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025 serine protease#PC00203;protease#PC00190 HUMAN|HGNC=24508|UniProtKB=B4DYI2 B4DYI2 SPATA31C2 PTHR21859:SF44 ACROSOME-SPECIFIC PROTEIN SPERMATOGENESIS-ASSOCIATED PROTEIN 31C1-RELATED HUMAN|HGNC=17358|UniProtKB=Q9H3S4 Q9H3S4 TPK1 PTHR13622:SF14 THIAMIN PYROPHOSPHOKINASE THIAMINE PYROPHOSPHOKINASE 1 transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740 small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152;alcohol metabolic process#GO:0006066;organophosphate biosynthetic process#GO:0090407;alcohol biosynthetic process#GO:0046165;pyrimidine-containing compound metabolic process#GO:0072527;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;sulfur compound metabolic process#GO:0006790;phosphorus metabolic process#GO:0006793;biosynthetic process#GO:0009058;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 transferase#PC00220;kinase#PC00137 Thiamin metabolism#P02780>Thiamine kinase#P03176 HUMAN|HGNC=9921|UniProtKB=P10745 P10745 RBP3 PTHR11261:SF3 INTERPHOTORECEPTOR RETINOID-BINDING PROTEIN RETINOL-BINDING PROTEIN 3 binding#GO:0005488;small molecule binding#GO:0036094;alcohol binding#GO:0043178;lipid binding#GO:0008289 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012 HUMAN|HGNC=12648|UniProtKB=Q9P0L0 Q9P0L0 VAPA PTHR10809:SF155 VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN A molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;protein-membrane adaptor activity#GO:0043495 developmental process#GO:0032502;endoplasmic reticulum membrane organization#GO:0090158;neuron differentiation#GO:0030182;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;organelle organization#GO:0006996;neuron projection development#GO:0031175;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;membrane organization#GO:0061024;endomembrane system organization#GO:0010256;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;neuron development#GO:0048666;system development#GO:0048731;anatomical structure development#GO:0048856;endoplasmic reticulum organization#GO:0007029;cellular component organization#GO:0016043;cell development#GO:0048468;cell differentiation#GO:0030154;cell projection organization#GO:0030030 membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;organelle membrane#GO:0031090;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;plasma membrane#GO:0005886;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cell periphery#GO:0071944;membrane#GO:0016020 membrane traffic protein#PC00150;membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=11572|UniProtKB=P26639 P26639 TARS1 PTHR11451:SF36 THREONINE-TRNA LIGASE THREONINE--TRNA LIGASE 1, CYTOPLASMIC catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;ligase activity#GO:0016874;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a tRNA#GO:0140101 protein biosynthetic process#GO:0160307;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;protein metabolic process#GO:0019538;RNA metabolic process#GO:0016070;translation#GO:0006412;amino acid metabolic process#GO:0006520;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;tRNA aminoacylation for protein translation#GO:0006418;tRNA aminoacylation#GO:0043039;amino acid activation#GO:0043038;macromolecule metabolic process#GO:0043170;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 aminoacyl-tRNA synthetase#PC00047 HUMAN|HGNC=2384|UniProtKB=Q16526 Q16526 CRY1 PTHR11455:SF16 CRYPTOCHROME CRYPTOCHROME-1 catalytic activity, acting on DNA#GO:0140097;heterocyclic compound binding#GO:1901363;carbon-carbon lyase activity#GO:0016830;lyase activity#GO:0016829;nucleoside phosphate binding#GO:1901265;flavin adenine dinucleotide binding#GO:0050660;binding#GO:0005488;nucleotide binding#GO:0000166;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;DNA binding#GO:0003677;ion binding#GO:0043167;nucleic acid binding#GO:0003676;small molecule binding#GO:0036094;anion binding#GO:0043168;deoxyribodipyrimidine photo-lyase activity#GO:0003904 regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;response to light stimulus#GO:0009416;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;response to external stimulus#GO:0009605;negative regulation of cellular process#GO:0048523;photoperiodism#GO:0009648;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;response to radiation#GO:0009314;negative regulation of macromolecule metabolic process#GO:0010605;regulation of circadian rhythm#GO:0042752;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;circadian rhythm#GO:0007623;rhythmic process#GO:0048511;response to stimulus#GO:0050896;negative regulation of metabolic process#GO:0009892;circadian regulation of gene expression#GO:0032922;response to abiotic stimulus#GO:0009628;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of macromolecule biosynthetic process#GO:0010558 nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 DNA photolyase#PC00014 Circadian clock system#P00015>cry#G01497;Circadian clock system#P00015>cry#G01501;Circadian clock system#P00015>Cry#P00505 HUMAN|HGNC=6883|UniProtKB=Q13387 Q13387 MAPK8IP2 PTHR47437:SF2 JNK-INTERACTING PROTEIN 1-LIKE PROTEIN C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 2 protein binding#GO:0005515;signaling adaptor activity#GO:0035591;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;protein-macromolecule adaptor activity#GO:0030674;kinase binding#GO:0019900;binding#GO:0005488;structural molecule activity#GO:0005198;MAP kinase scaffold activity#GO:0005078;protein complex scaffold activity#GO:0140378;molecular adaptor activity#GO:0060090 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;JNK cascade#GO:0007254;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;intracellular signaling cassette#GO:0141124;MAPK cascade#GO:0000165;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=29332|UniProtKB=Q5T1S8 Q5T1S8 NCMAP PTHR35974:SF1 NONCOMPACT MYELIN-ASSOCIATED PROTEIN NONCOMPACT MYELIN-ASSOCIATED PROTEIN structural molecule activity#GO:0005198 cell differentiation#GO:0030154;cell development#GO:0048468;cellular component organization#GO:0016043;peripheral nervous system development#GO:0007422;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;cellular component assembly involved in morphogenesis#GO:0010927;glial cell differentiation#GO:0010001;multicellular organismal process#GO:0032501;cellular component assembly#GO:0022607;nervous system development#GO:0007399;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;anatomical structure formation involved in morphogenesis#GO:0048646;myelination#GO:0042552;neurogenesis#GO:0022008;gliogenesis#GO:0042063;cellular anatomical entity morphogenesis#GO:0032989;developmental process#GO:0032502 cellular anatomical structure#GO:0110165;cell projection#GO:0042995;myelin sheath#GO:0043209;plasma membrane bounded cell projection#GO:0120025;axon#GO:0030424;main axon#GO:0044304;neuron projection#GO:0043005 structural protein#PC00211;myelin protein#PC00161 HUMAN|HGNC=25220|UniProtKB=Q9BV87 Q9BV87 CNPPD1 PTHR15615:SF127 FAMILY NOT NAMED PROTEIN CNPPD1 enzyme regulator activity#GO:0030234;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;protein kinase regulator activity#GO:0019887;cyclin-dependent protein kinase regulator activity#GO:0019914;cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538 nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex#GO:1990234;protein kinase complex#GO:1902911;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554 HUMAN|HGNC=12986|UniProtKB=O14628 O14628 ZNF195 PTHR24384:SF87 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED ZINC FINGER PROTEIN 195 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218 HUMAN|HGNC=1318|UniProtKB=P01024 P01024 C3 PTHR11412:SF81 MACROGLOBULIN / COMPLEMENT COMPLEMENT C3 cytokine activity#GO:0005125;signaling receptor binding#GO:0005102;cytokine receptor binding#GO:0005126;binding#GO:0005488;protein binding#GO:0005515;chemokine receptor binding#GO:0042379;molecular function activator activity#GO:0140677;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;G protein-coupled receptor binding#GO:0001664;chemokine activity#GO:0008009;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772 positive regulation of response to stimulus#GO:0048584;defense response to other organism#GO:0098542;biological regulation#GO:0065007;response to other organism#GO:0051707;response to biotic stimulus#GO:0009607;positive regulation of immune system process#GO:0002684;response to stress#GO:0006950;positive regulation of biological process#GO:0048518;defense response to symbiont#GO:0140546;activation of immune response#GO:0002253;complement activation#GO:0006956;immune response#GO:0006955;innate immune response#GO:0045087;response to external stimulus#GO:0009605;defense response#GO:0006952;humoral immune response#GO:0006959;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;immune effector process#GO:0002252;response to stimulus#GO:0050896;regulation of immune system process#GO:0002682;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;regulation of biological process#GO:0050789;immune system process#GO:0002376;regulation of immune response#GO:0050776 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;extracellular region#GO:0005576;extracellular protein-containing complex#GO:0140392;catalytic complex#GO:1902494 protease inhibitor#PC00191 HUMAN|HGNC=4326|UniProtKB=P23415 P23415 GLRA1 PTHR18945:SF213 NEUROTRANSMITTER GATED ION CHANNEL GLYCINE RECEPTOR SUBUNIT ALPHA-1 channel activity#GO:0015267;monoatomic anion channel activity#GO:0005253;gated channel activity#GO:0022836;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic ion channel activity#GO:0005216;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic anion transmembrane transporter activity#GO:0008509;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;chloride transmembrane transporter activity#GO:0015108;chloride channel activity#GO:0005254 monoatomic ion transmembrane transport#GO:0034220;monoatomic anion transmembrane transport#GO:0098656;cellular process#GO:0009987;monoatomic anion transport#GO:0006820;inorganic anion transport#GO:0015698;monoatomic ion transport#GO:0006811;localization#GO:0051179;chloride transmembrane transport#GO:1902476;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810;chloride transport#GO:0006821 cell junction#GO:0030054;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;synaptic membrane#GO:0097060;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;plasma membrane region#GO:0098590;postsynaptic specialization#GO:0099572;plasma membrane#GO:0005886;postsynapse#GO:0098794;membrane#GO:0016020;cell periphery#GO:0071944 ligand-gated ion channel#PC00141 HUMAN|HGNC=30290|UniProtKB=Q9NZQ0 Q9NZQ0 DNAJC27 PTHR24073:SF269 DRAB5-RELATED DNAJ HOMOLOG SUBFAMILY C MEMBER 27 ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818 protein transport#GO:0015031;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;macromolecule localization#GO:0033036 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 G-protein#PC00020;small GTPase#PC00208 Integrin signalling pathway#P00034>Rap1#P00906;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Rap1#P00734 HUMAN|HGNC=21216|UniProtKB=Q6BDS2 Q6BDS2 BLTP3A PTHR22774:SF15 CHOREIN N-TERMINAL DOMAIN-CONTAINING PROTEIN BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 3A lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104;transporter activity#GO:0005215;lipid transfer activity#GO:0120013 cellular component organization#GO:0016043;cytosolic transport#GO:0016482;lipid localization#GO:0010876;cellular localization#GO:0051641;localization#GO:0051179;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;macromolecule localization#GO:0033036;retrograde transport, endosome to Golgi#GO:0042147;membrane organization#GO:0061024;vesicle-mediated transport#GO:0016192;lipid transport#GO:0006869;transport#GO:0006810;Golgi vesicle transport#GO:0048193;intracellular transport#GO:0046907;endosomal transport#GO:0016197;establishment of localization#GO:0051234;intermembrane lipid transfer#GO:0120009;cellular component organization or biogenesis#GO:0071840 cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;vesicle#GO:0031982;intracellular vesicle#GO:0097708 HUMAN|HGNC=5577|UniProtKB=P01814 P01814 IGHV2-70 PTHR23266:SF389 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 2-70-RELATED antigen binding#GO:0003823;binding#GO:0005488 immune system process#GO:0002376;immune effector process#GO:0002252;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;immunoglobulin mediated immune response#GO:0016064;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immune response#GO:0006955;response to stimulus#GO:0050896;adaptive immune response#GO:0002250 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=28642|UniProtKB=Q8NEA5 Q8NEA5 C19orf18 PTHR38000:SF1 RIKEN CDNA 2900092C05 RIKEN CDNA 2900092C05 GENE HUMAN|HGNC=25463|UniProtKB=Q86WN1 Q86WN1 FCHSD1 PTHR15735:SF4 FCH AND DOUBLE SH3 DOMAINS PROTEIN F-BAR AND DOUBLE SH3 DOMAINS PROTEIN 1 phospholipid binding#GO:0005543;phosphatidylinositol phosphate binding#GO:1901981;ion binding#GO:0043167;phosphatidylinositol-4,5-bisphosphate binding#GO:0005546;anion binding#GO:0043168;binding#GO:0005488;small molecule binding#GO:0036094;phosphatidylinositol bisphosphate binding#GO:1902936;lipid binding#GO:0008289 cell communication#GO:0007154;regulation of biological quality#GO:0065008;trans-synaptic signaling#GO:0099537;regulation of actin filament length#GO:0030832;anterograde trans-synaptic signaling#GO:0098916;regulation of cytoskeleton organization#GO:0051493;regulation of protein polymerization#GO:0032271;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of cellular component biogenesis#GO:0044087;chemical synaptic transmission#GO:0007268;regulation of protein-containing complex assembly#GO:0043254;cellular component organization#GO:0016043;regulation of supramolecular fiber organization#GO:1902903;regulation of cellular component size#GO:0032535;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;cellular component organization or biogenesis#GO:0071840;regulation of anatomical structure size#GO:0090066;regulation of actin filament-based process#GO:0032970;neuromuscular synaptic transmission#GO:0007274;regulation of actin filament polymerization#GO:0030833;membrane organization#GO:0061024;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;regulation of actin polymerization or depolymerization#GO:0008064;regulation of actin cytoskeleton organization#GO:0032956;synaptic signaling#GO:0099536;cellular process#GO:0009987;regulation of actin filament organization#GO:0110053 intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;cell periphery#GO:0071944;endomembrane system#GO:0012505;plasma membrane#GO:0005886;cytoplasm#GO:0005737;recycling endosome#GO:0055037;cell junction#GO:0030054;neuromuscular junction#GO:0031594 cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HUMAN|HGNC=10919|UniProtKB=Q15849 Q15849 SLC14A2 PTHR10464:SF6 UREA TRANSPORTER UREA TRANSPORTER 2 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 transport#GO:0006810;cellular process#GO:0009987;nitrogen compound transport#GO:0071705;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227 HUMAN|HGNC=25203|UniProtKB=Q6PI78 Q6PI78 TMEM65 PTHR21706:SF16 TRANSMEMBRANE PROTEIN 65 TRANSMEMBRANE PROTEIN 65 developmental process#GO:0032502;animal gross anatomical part developmental process#GO:0160108;regulation of system process#GO:0044057;system development#GO:0048731;anatomical structure development#GO:0048856;animal organ development#GO:0048513;multicellular organism development#GO:0007275;regulation of biological process#GO:0050789;regulation of heart contraction#GO:0008016;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;heart development#GO:0007507;circulatory system development#GO:0072359 mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=28442|UniProtKB=Q8N7B6 Q8N7B6 PACRGL PTHR21207:SF1 PARKIN COREGULATED GENE PROTEIN PARK2 COREGULATED PACRG-LIKE PROTEIN HUMAN|HGNC=7667|UniProtKB=P19338 P19338 NCL PTHR48034:SF4 TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED NUCLEOLIN nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;RNA binding#GO:0003723 mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;spliceosomal complex#GO:0005681;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031 HUMAN|HGNC=21173|UniProtKB=Q96GA3 Q96GA3 LTV1 PTHR21531:SF0 LOW-TEMPERATURE VIABILITY PROTEIN LTV1-RELATED PROTEIN LTV1 HOMOLOG establishment of organelle localization#GO:0051656;ribonucleoprotein complex biogenesis#GO:0022613;localization#GO:0051179;cellular localization#GO:0051641;nuclear transport#GO:0051169;nuclear export#GO:0051168;ribosome biogenesis#GO:0042254;organelle localization#GO:0051640;ribosome localization#GO:0033750;nucleocytoplasmic transport#GO:0006913;ribosomal small subunit export from nucleus#GO:0000056;cellular component biogenesis#GO:0044085;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;intracellular transport#GO:0046907;ribosomal subunit export from nucleus#GO:0000054;ribosomal small subunit biogenesis#GO:0042274;transport#GO:0006810 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;preribosome#GO:0030684;ribonucleoprotein complex#GO:1990904 HUMAN|HGNC=29422|UniProtKB=Q6ZW76 Q6ZW76 ANKS3 PTHR24184:SF29 SI:CH211-189E2.2 ANKYRIN REPEAT AND SAM DOMAIN-CONTAINING PROTEIN 3 cilium#GO:0005929;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995 HUMAN|HGNC=27234|UniProtKB=Q86X53 Q86X53 ERICH1 PTHR22444:SF1 GLUTAMATE-RICH PROTEIN 1 GLUTAMATE-RICH PROTEIN 1 HUMAN|HGNC=18396|UniProtKB=O95969 O95969 SCGB1D2 PTHR11332:SF6 SECRETOGLOBIN FAMILY 1D SECRETOGLOBIN FAMILY 1D MEMBER 2 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 transfer/carrier protein#PC00219 HUMAN|HGNC=9831|UniProtKB=P15918 P15918 RAG1 PTHR11539:SF0 VDJ RECOMBINATION ACTIVATING PROTEIN 1 RAG1 V(D)J RECOMBINATION-ACTIVATING PROTEIN 1 endodeoxyribonuclease#PC00093;DNA metabolism protein#PC00009 HUMAN|HGNC=11866|UniProtKB=Q8IYR6 Q8IYR6 TMEFF1 PTHR21632:SF3 REGULATORY PROTEIN ZESTE TOMOREGULIN-1 molecular function regulator activity#GO:0098772;molecular function inhibitor activity#GO:0140678 immune system process#GO:0002376;response to external stimulus#GO:0009605;defense response#GO:0006952;innate immune response#GO:0045087;immune response#GO:0006955;defense response to symbiont#GO:0140546;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to other organism#GO:0051707;response to stimulus#GO:0050896;defense response to other organism#GO:0098542 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=2685|UniProtKB=Q92904 Q92904 DAZL PTHR11176:SF4 BOULE-RELATED DELETED IN AZOOSPERMIA-LIKE translation regulator activity#GO:0045182 regulation of mRNA metabolic process#GO:1903311;negative regulation of RNA metabolic process#GO:0051253;positive regulation of macromolecule metabolic process#GO:0010604;mRNA stabilization#GO:0048255;regulation of protein metabolic process#GO:0051246;positive regulation of biological process#GO:0048518;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;RNA stabilization#GO:0043489;regulation of biological quality#GO:0065008;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of translational initiation#GO:0006446;positive regulation of protein metabolic process#GO:0051247;negative regulation of metabolic process#GO:0009892;regulation of mRNA stability#GO:0043488;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;positive regulation of gene expression#GO:0010628;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;negative regulation of RNA catabolic process#GO:1902369;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;positive regulation of biosynthetic process#GO:0009891;negative regulation of catabolic process#GO:0009895;positive regulation of translation#GO:0045727;regulation of RNA metabolic process#GO:0051252;regulation of RNA stability#GO:0043487;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031 HUMAN|HGNC=7032|UniProtKB=P55081 P55081 MFAP1 PTHR15327:SF0 MICROFIBRIL-ASSOCIATED PROTEIN MICROFIBRILLAR-ASSOCIATED PROTEIN 1 gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187 nucleus#GO:0005634;spliceosomal complex#GO:0005681;U2-type spliceosomal complex#GO:0005684;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513 extracellular matrix protein#PC00102 HUMAN|HGNC=21749|UniProtKB=Q7L5N1 Q7L5N1 COPS6 PTHR10540:SF8 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED COP9 SIGNALOSOME COMPLEX SUBUNIT 6 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;COP9 signalosome#GO:0008180;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634 translation initiation factor#PC00224 HUMAN|HGNC=28270|UniProtKB=Q96D70 Q96D70 R3HDM4 PTHR32019:SF2 R3H DOMAIN-CONTAINING PROTEIN 4 R3H DOMAIN-CONTAINING PROTEIN 4 HUMAN|HGNC=25235|UniProtKB=Q9UJG1 Q9UJG1 MOSPD1 PTHR34441:SF2 MOTILE SPERM DOMAIN-CONTAINING PROTEIN 1 MOTILE SPERM DOMAIN-CONTAINING PROTEIN 1 HUMAN|HGNC=28396|UniProtKB=Q5HYA8 Q5HYA8 TMEM67 PTHR21274:SF2 MECKELIN MECKELIN organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031;cilium organization#GO:0044782;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cell projection assembly#GO:0030031;cilium assembly#GO:0060271;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cell projection organization#GO:0030030 cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;ciliary transition zone#GO:0035869;cilium#GO:0005929 HUMAN|HGNC=40022|UniProtKB=A6NMD0 A6NMD0 IFITM10 PTHR13999:SF9 INTERFERON INDUCIBLE TRANSMEMBRANE PROTEIN INTERFERON-INDUCED TRANSMEMBRANE PROTEIN 10 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 defense/immunity protein#PC00090 HUMAN|HGNC=9618|UniProtKB=Q13308 Q13308 PTK7 PTHR45080:SF21 CONTACTIN 5 INACTIVE TYROSINE-PROTEIN KINASE 7 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular component organization#GO:0016043;regulation of canonical Wnt signaling pathway#GO:0060828;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111;regulation of cellular process#GO:0050794;cell junction organization#GO:0034330;synapse organization#GO:0050808;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;cellular component organization or biogenesis#GO:0071840 cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;neuronal cell body#GO:0043025;somatodendritic compartment#GO:0036477;cell-cell junction#GO:0005911;cell body#GO:0044297;neuron projection#GO:0043005;cell junction#GO:0030054;anchoring junction#GO:0070161;axon#GO:0030424 HUMAN|HGNC=23749|UniProtKB=Q8N5B7 Q8N5B7 CERS5 PTHR12560:SF8 LONGEVITY ASSURANCE FACTOR 1 LAG1 CERAMIDE SYNTHASE 5 acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746 lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;ceramide metabolic process#GO:0006672;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;sphingolipid biosynthetic process#GO:0030148;ceramide biosynthetic process#GO:0046513;lipid metabolic process#GO:0006629 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;transferase#PC00220 HUMAN|HGNC=1615|UniProtKB=P78371 P78371 CCT2 PTHR11353:SF23 CHAPERONIN T-COMPLEX PROTEIN 1 SUBUNIT BETA protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;gene expression#GO:0010467;protein maturation#GO:0051604;protein folding#GO:0006457;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;chaperonin-containing T-complex#GO:0005832;protein folding chaperone complex#GO:0101031 chaperonin#PC00073 HUMAN|HGNC=4523|UniProtKB=Q9NYM4 Q9NYM4 GPR83 PTHR24238:SF82 G-PROTEIN COUPLED RECEPTOR G PROTEIN-COUPLED RECEPTOR 83 molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;signaling receptor activity#GO:0038023;neuropeptide receptor activity#GO:0008188;G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888 neuropeptide signaling pathway#GO:0007218;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=26533|UniProtKB=Q96M83 Q96M83 CCDC7 PTHR22035:SF4 COILED-COIL DOMAIN-CONTAINING PROTEIN 7 COILED-COIL DOMAIN-CONTAINING PROTEIN 7 HUMAN|HGNC=25275|UniProtKB=Q68DN1 Q68DN1 SPATA31H1 PTHR33888:SF1 RIKEN CDNA 4932415D10 GENE SPERMATOGENESIS-ASSOCIATED PROTEIN 31H1 HUMAN|HGNC=28144|UniProtKB=Q5T6V5 Q5T6V5 QNG1 PTHR21314:SF0 QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE-RELATED QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;RNA biosynthetic process#GO:0032774;tRNA modification#GO:0006400;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 HUMAN|HGNC=20418|UniProtKB=Q9NTI5 Q9NTI5 PDS5B PTHR12663:SF1 ANDROGEN INDUCED INHIBITOR OF PROLIFERATION AS3 / PDS5-RELATED SISTER CHROMATID COHESION PROTEIN PDS5 HOMOLOG B chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=18246|UniProtKB=Q9Y2S2 Q9Y2S2 CRYL1 PTHR48075:SF1 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN LAMBDA-CRYSTALLIN HOMOLOG catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262;dehydrogenase#PC00092 HUMAN|HGNC=17053|UniProtKB=Q9Y2H5 Q9Y2H5 PLEKHA6 PTHR12752:SF5 PHOSPHOINOSITOL 3-PHOSPHATE-BINDING PROTEIN PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 6 HUMAN|HGNC=14179|UniProtKB=Q9H6Q4 Q9H6Q4 CIAO3 PTHR11615:SF322 NITRATE, FORMATE, IRON DEHYDROGENASE CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 3 cellular process#GO:0009987;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;iron-sulfur cluster assembly#GO:0016226;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607 intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 metabolite interconversion enzyme#PC00262;dehydrogenase#PC00092 HUMAN|HGNC=4634|UniProtKB=P28161 P28161 GSTM2 PTHR11571:SF254 GLUTATHIONE S-TRANSFERASE GLUTATHIONE S-TRANSFERASE MU 2 glutathione transferase activity#GO:0004364;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765 metabolic process#GO:0008152;glutathione metabolic process#GO:0006749;sulfur compound metabolic process#GO:0006790;modified amino acid metabolic process#GO:0006575;cellular process#GO:0009987 transferase#PC00220 HUMAN|HGNC=24163|UniProtKB=Q9BUH8 Q9BUH8 BEGAIN PTHR28664:SF2 TIGHT JUNCTION-ASSOCIATED PROTEIN 1 BRAIN-ENRICHED GUANYLATE KINASE-ASSOCIATED PROTEIN signaling#GO:0023052;chemical synaptic transmission, postsynaptic#GO:0099565;anterograde trans-synaptic signaling#GO:0098916;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of postsynaptic membrane potential#GO:0060078;cellular response to stimulus#GO:0051716;chemical synaptic transmission#GO:0007268;regulation of biological quality#GO:0065008;cell communication#GO:0007154;nervous system process#GO:0050877;trans-synaptic signaling#GO:0099537;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;signal transduction#GO:0007165;cellular process#GO:0009987;synaptic signaling#GO:0099536;system process#GO:0003008;regulation of membrane potential#GO:0042391;cell surface receptor signaling pathway#GO:0007166 cell junction#GO:0030054;cellular anatomical structure#GO:0110165;synapse#GO:0045202 cell junction protein#PC00070;tight junction#PC00214 HUMAN|HGNC=17649|UniProtKB=Q9HBV1 Q9HBV1 POPDC3 PTHR12101:SF18 POPEYE DOMAIN CONTAINING PROTEIN POPEYE DOMAIN-CONTAINING PROTEIN 3 carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;ribonucleotide binding#GO:0032553;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;nucleotide binding#GO:0000166;ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265;small molecule binding#GO:0036094;binding#GO:0005488;anion binding#GO:0043168 cell adhesion#GO:0007155;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;regulation of biological quality#GO:0065008;anatomical structure development#GO:0048856;muscle cell differentiation#GO:0042692;circulatory system development#GO:0072359;cell differentiation#GO:0030154;muscle structure development#GO:0061061;developmental process#GO:0032502;striated muscle cell differentiation#GO:0051146;multicellular organism development#GO:0007275;animal organ development#GO:0048513;cellular developmental process#GO:0048869;regulation of membrane potential#GO:0042391;cellular process#GO:0009987;cell-cell adhesion#GO:0098609;biological regulation#GO:0065007;heart development#GO:0007507;multicellular organismal process#GO:0032501 cell junction#GO:0030054;sarcolemma#GO:0042383;tight junction#GO:0070160;anchoring junction#GO:0070161;apical junction complex#GO:0043296;bicellular tight junction#GO:0005923;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cell-cell junction#GO:0005911;membrane#GO:0016020;cell periphery#GO:0071944 HUMAN|HGNC=6502|UniProtKB=P08865 P08865 RPSA PTHR11489:SF17 40S RIBOSOMAL PROTEIN SA SMALL RIBOSOMAL SUBUNIT PROTEIN US2-RELATED structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 ribosomal small subunit biogenesis#GO:0042274;metabolic process#GO:0008152;protein-containing complex organization#GO:0043933;protein-RNA complex organization#GO:0071826;ribosomal small subunit assembly#GO:0000028;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular component assembly#GO:0022607;translation#GO:0006412;ribosome biogenesis#GO:0042254;ribosome assembly#GO:0042255;organelle assembly#GO:0070925;protein metabolic process#GO:0019538;protein-RNA complex assembly#GO:0022618;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;membraneless organelle assembly#GO:0140694;ribonucleoprotein complex biogenesis#GO:0022613;protein biosynthetic process#GO:0160307;cytoplasmic translation#GO:0002181 cytosol#GO:0005829;cytosolic ribosome#GO:0022626;ribosome#GO:0005840;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;cytosolic small ribosomal subunit#GO:0022627;small ribosomal subunit#GO:0015935;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202 HUMAN|HGNC=17838|UniProtKB=Q9BYG3 Q9BYG3 NIFK PTHR46754:SF1 MKI67 FHA DOMAIN-INTERACTING NUCLEOLAR PHOSPHOPROTEIN MKI67 FHA DOMAIN-INTERACTING NUCLEOLAR PHOSPHOPROTEIN binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634 HUMAN|HGNC=11757|UniProtKB=Q07654 Q07654 TFF3 PTHR13826:SF16 INTESTINAL TREFOIL FACTOR-RELATED TREFOIL FACTOR 3 epithelial structure maintenance#GO:0010669;homeostatic process#GO:0042592;multicellular organismal process#GO:0032501;anatomical structure homeostasis#GO:0060249;digestion#GO:0007586;multicellular organismal-level homeostasis#GO:0048871;system process#GO:0003008;tissue homeostasis#GO:0001894 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HUMAN|HGNC=16964|UniProtKB=O00399 O00399 DCTN6 PTHR13072:SF0 DYNACTIN 6 DYNACTIN SUBUNIT 6 protein-containing complex binding#GO:0044877;binding#GO:0005488 mitotic cell cycle#GO:0000278;mitotic spindle organization#GO:0007052;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cell cycle#GO:0007049;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cellular component organization#GO:0016043;cellular process#GO:0009987;cell cycle process#GO:0022402;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226;mitotic cell cycle process#GO:1903047;microtubule-based process#GO:0007017 microtubule cytoskeleton#GO:0015630;actin cytoskeleton#GO:0015629;organelle#GO:0043226;microtubule associated complex#GO:0005875;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 microtubule binding motor protein#PC00156 HUMAN|HGNC=18160|UniProtKB=Q9Y603 Q9Y603 ETV7 PTHR11849:SF77 ETS TRANSCRIPTION FACTOR ETV7 transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 winged helix/forkhead transcription factor#PC00246;DNA-binding transcription factor#PC00218 HUMAN|HGNC=9690|UniProtKB=O95997 O95997 PTTG1 PTHR10418:SF7 SECURIN-3 SECURIN molecular function inhibitor activity#GO:0140678;cysteine-type endopeptidase inhibitor activity#GO:0004869;enzyme regulator activity#GO:0030234;peptidase regulator activity#GO:0061134;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866;enzyme inhibitor activity#GO:0004857 organelle fission#GO:0048285;meiosis I cell cycle process#GO:0061982;nuclear division#GO:0000280;sexual reproduction#GO:0019953;reproductive process#GO:0022414;cell cycle#GO:0007049;cellular component organization#GO:0016043;meiosis I#GO:0007127;nuclear chromosome segregation#GO:0098813;meiotic cell cycle process#GO:1903046;cell cycle process#GO:0022402;cellular component organization or biogenesis#GO:0071840;homologous chromosome segregation#GO:0045143;meiotic nuclear division#GO:0140013;meiotic chromosome segregation#GO:0045132;meiotic cell cycle#GO:0051321;chromosome segregation#GO:0007059;organelle organization#GO:0006996;cellular process#GO:0009987 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=23813|UniProtKB=Q9BQI4 Q9BQI4 CCDC3 PTHR31663:SF4 COILED-COIL DOMAIN-CONTAINING PROTEIN 3 COILED-COIL DOMAIN-CONTAINING PROTEIN 3 regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of gene expression#GO:0010629;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=20474|UniProtKB=Q8IU68 Q8IU68 TMC8 PTHR23302:SF39 TRANSMEMBRANE CHANNEL-RELATED TRANSMEMBRANE CHANNEL-LIKE PROTEIN 8 channel activity#GO:0015267;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;gated channel activity#GO:0022836;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133 HUMAN|HGNC=28880|UniProtKB=Q9H0U3 Q9H0U3 MAGT1 PTHR12692:SF2 DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE-RELATED DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT MAGT1 metal ion transport#GO:0030001;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;protein metabolic process#GO:0019538;transmembrane transport#GO:0055085;biosynthetic process#GO:0009058;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;glycoprotein biosynthetic process#GO:0009101;macromolecule metabolic process#GO:0043170;establishment of localization#GO:0051234;carbohydrate derivative biosynthetic process#GO:1901137;glycoprotein metabolic process#GO:0009100;transport#GO:0006810;magnesium ion transport#GO:0015693;metabolic process#GO:0008152 membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;oligosaccharyltransferase complex#GO:0008250;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;endoplasmic reticulum subcompartment#GO:0098827;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;membrane#GO:0016020;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;endoplasmic reticulum#GO:0005783;transferase complex#GO:1990234;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;endoplasmic reticulum protein-containing complex#GO:0140534 glycosyltransferase#PC00111;transferase#PC00220 HUMAN|HGNC=30725|UniProtKB=Q9UKR8 Q9UKR8 TSPAN16 PTHR19282:SF455 TETRASPANIN TETRASPANIN-16 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HUMAN|HGNC=30785|UniProtKB=Q9UHR5 Q9UHR5 SAP30BP PTHR13464:SF0 TRANSCRIPTIONAL REGULATOR PROTEIN HCNGP SAP30-BINDING PROTEIN membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=12518|UniProtKB=P55851 P55851 UCP2 PTHR45618:SF1 MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED DICARBOXYLATE CARRIER SLC25A8 monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;proton transmembrane transporter activity#GO:0015078 mitochondrial transmembrane transport#GO:1990542;adaptive thermogenesis#GO:1990845;transmembrane transport#GO:0055085;cellular localization#GO:0051641;localization#GO:0051179;response to abiotic stimulus#GO:0009628;homeostatic process#GO:0042592;response to cold#GO:0009409;response to stimulus#GO:0050896;mitochondrial transport#GO:0006839;transport#GO:0006810;temperature homeostasis#GO:0001659;intracellular transport#GO:0046907;multicellular organismal-level homeostasis#GO:0048871;establishment of localization#GO:0051234;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;response to stress#GO:0006950;response to temperature stimulus#GO:0009266;multicellular organismal process#GO:0032501 intracellular organelle#GO:0043229;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 transporter#PC00227;secondary carrier transporter#PC00258 HUMAN|HGNC=26317|UniProtKB=Q96LU5 Q96LU5 IMMP1L PTHR12383:SF33 PROTEASE FAMILY S26 MITOCHONDRIAL INNER MEMBRANE PROTEASE-RELATED MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 1 endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 protein localization to mitochondrion#GO:0070585;macromolecule localization#GO:0033036;intracellular protein localization#GO:0008104;localization#GO:0051179;protein localization to organelle#GO:0033365 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;organelle envelope#GO:0031967;membrane protein complex#GO:0098796;organelle membrane#GO:0031090;endopeptidase complex#GO:1905369;inner mitochondrial membrane protein complex#GO:0098800;peptidase complex#GO:1905368;cytoplasm#GO:0005737;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;mitochondrial membrane#GO:0031966;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020 protein modifying enzyme#PC00260;protease#PC00190 HUMAN|HGNC=12823|UniProtKB=O43895 O43895 XPNPEP2 PTHR43763:SF4 XAA-PRO AMINOPEPTIDASE 1 XAA-PRO AMINOPEPTIDASE 2 protease#PC00190 HUMAN|HGNC=33148|UniProtKB=G2XKQ0 G2XKQ0 SUMO1P1 PTHR10562:SF103 SMALL UBIQUITIN-RELATED MODIFIER SMALL UBIQUITIN-RELATED MODIFIER 5 enzyme binding#GO:0019899;binding#GO:0005488;ubiquitin-like protein ligase binding#GO:0044389;protein binding#GO:0005515 cellular process#GO:0009987;protein modification by small protein conjugation#GO:0032446;protein modification process#GO:0036211;primary metabolic process#GO:0044238;post-translational protein modification#GO:0043687;protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152;protein sumoylation#GO:0016925;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170 intracellular membraneless organelle#GO:0043232;nuclear body#GO:0016604;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membraneless organelle#GO:0043228;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;PML body#GO:0016605;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 HUMAN|HGNC=17186|UniProtKB=Q8WXH4 Q8WXH4 ASB11 PTHR24136:SF14 SOWAH (DROSOPHILA) HOMOLOG ANKYRIN REPEAT AND SOCS BOX PROTEIN 11 positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;biological regulation#GO:0065007;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;positive regulation of macromolecule metabolic process#GO:0010604;metabolic process#GO:0008152;regulation of catabolic process#GO:0009894;macromolecule metabolic process#GO:0043170;positive regulation of catabolic process#GO:0009896;regulation of biological process#GO:0050789;protein modification by small protein conjugation#GO:0032446;protein modification process#GO:0036211;primary metabolic process#GO:0044238;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of protein metabolic process#GO:0051247;protein modification by small protein conjugation or removal#GO:0070647;positive regulation of protein catabolic process#GO:0045732;regulation of protein catabolic process#GO:0042176;positive regulation of metabolic process#GO:0009893;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412 HUMAN|HGNC=26595|UniProtKB=Q8N584 Q8N584 TTC39C PTHR31859:SF24 TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER TETRATRICOPEPTIDE REPEAT PROTEIN 39C organelle assembly#GO:0070925;animal gross anatomical part developmental process#GO:0160108;embryonic organ development#GO:0048568;anatomical structure development#GO:0048856;cilium organization#GO:0044782;ear development#GO:0043583;cellular component organization#GO:0016043;cilium assembly#GO:0060271;anatomical structure morphogenesis#GO:0009653;cell projection organization#GO:0030030;sensory organ morphogenesis#GO:0090596;animal organ morphogenesis#GO:0009887;plasma membrane bounded cell projection assembly#GO:0120031;sensory organ development#GO:0007423;developmental process#GO:0032502;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;embryonic morphogenesis#GO:0048598;animal organ development#GO:0048513;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;inner ear morphogenesis#GO:0042472;inner ear development#GO:0048839;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component assembly#GO:0022607;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;embryo development#GO:0009790 HUMAN|HGNC=26894|UniProtKB=Q4KMQ1 Q4KMQ1 TPRN PTHR21685:SF1 TON-B BOX DOMAIN TAPERIN anatomical structure development#GO:0048856;system development#GO:0048731;embryonic organ development#GO:0048568;sensory perception#GO:0007600;sensory perception of mechanical stimulus#GO:0050954;animal organ morphogenesis#GO:0009887;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;system process#GO:0003008;epidermis development#GO:0008544;sensory organ development#GO:0007423;developmental process#GO:0032502;tissue development#GO:0009888;epithelial cell differentiation#GO:0030855;multicellular organismal process#GO:0032501;epidermal cell differentiation#GO:0009913;epithelium development#GO:0060429;plasma membrane bounded cell projection organization#GO:0120036;inner ear development#GO:0048839;ear development#GO:0043583;neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;nervous system process#GO:0050877;generation of neurons#GO:0048699;cell morphogenesis#GO:0000902;sensory organ morphogenesis#GO:0090596;sensory perception of sound#GO:0007605;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell development#GO:0048468;cellular component organization#GO:0016043;inner ear receptor cell stereocilium organization#GO:0060122;anatomical structure morphogenesis#GO:0009653;animal organ development#GO:0048513;embryonic morphogenesis#GO:0048598;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;neuron differentiation#GO:0030182;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;embryo development#GO:0009790;hair cell differentiation#GO:0035315;inner ear morphogenesis#GO:0042472;neuron projection development#GO:0031175;cellular process#GO:0009987 cluster of actin-based cell projections#GO:0098862;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;stereocilium#GO:0032420;cytoskeleton#GO:0005856;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;neuron projection#GO:0043005;actin-based cell projection#GO:0098858;actin cytoskeleton#GO:0015629 HUMAN|HGNC=1667|UniProtKB=P28907 P28907 CD38 PTHR10912:SF5 ADP-RIBOSYL CYCLASE ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE 1 hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;catalytic activity#GO:0003824 positive regulation of lymphocyte proliferation#GO:0050671;regulation of cell population proliferation#GO:0042127;positive regulation of lymphocyte activation#GO:0051251;regulation of biological process#GO:0050789;positive regulation of multicellular organismal process#GO:0051240;regulation of cell activation#GO:0050865;regulation of leukocyte activation#GO:0002694;positive regulation of cell population proliferation#GO:0008284;positive regulation of B cell proliferation#GO:0030890;regulation of lymphocyte activation#GO:0051249;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;positive regulation of leukocyte activation#GO:0002696;positive regulation of leukocyte proliferation#GO:0070665;regulation of B cell proliferation#GO:0030888;regulation of leukocyte proliferation#GO:0070663;positive regulation of mononuclear cell proliferation#GO:0032946;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of immune system process#GO:0002684;regulation of mononuclear cell proliferation#GO:0032944;regulation of B cell activation#GO:0050864;biological regulation#GO:0065007;regulation of multicellular organismal process#GO:0051239;positive regulation of cell activation#GO:0050867;regulation of lymphocyte proliferation#GO:0050670 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 cyclase#PC00079;metabolite interconversion enzyme#PC00262 CCKR signaling map#P06959>CD38#P07204 HUMAN|HGNC=11079|UniProtKB=Q92581 Q92581 SLC9A6 PTHR10110:SF94 SODIUM/HYDROGEN EXCHANGER SODIUM_HYDROGEN EXCHANGER 6 potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075;metal cation:proton antiporter activity#GO:0051139;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;antiporter activity#GO:0015297;proton transmembrane transporter activity#GO:0015078;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 import across plasma membrane#GO:0098739;inorganic ion import across plasma membrane#GO:0099587;homeostatic process#GO:0042592;metal ion transport#GO:0030001;intracellular monoatomic ion homeostasis#GO:0006873;sodium ion transport#GO:0006814;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;regulation of pH#GO:0006885;regulation of intracellular pH#GO:0051453;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;import into cell#GO:0098657;establishment of localization#GO:0051234;inorganic cation import across plasma membrane#GO:0098659;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;chemical homeostasis#GO:0048878;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;transport#GO:0006810 endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;recycling endosome#GO:0055037;cell periphery#GO:0071944;membrane#GO:0016020;cytoplasm#GO:0005737;plasma membrane#GO:0005886;endomembrane system#GO:0012505 secondary carrier transporter#PC00258 HUMAN|HGNC=8994|UniProtKB=Q99755 Q99755 PIP5K1A PTHR23086:SF54 PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE PHOSPHATIDYLINOSITOL 4-PHOSPHATE 5-KINASE TYPE-1 ALPHA lipid kinase activity#GO:0001727;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;transferase activity#GO:0016740;phosphatidylinositol kinase activity#GO:0052742;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 organophosphate biosynthetic process#GO:0090407;phosphatidylinositol phosphate biosynthetic process#GO:0046854;phospholipid biosynthetic process#GO:0008654;glycerolipid metabolic process#GO:0046486;phospholipid metabolic process#GO:0006644;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474;lipid biosynthetic process#GO:0008610;glycerophospholipid metabolic process#GO:0006650;biosynthetic process#GO:0009058;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transferase#PC00220;kinase#PC00137 HUMAN|HGNC=9936|UniProtKB=P04000 P04000 OPN1LW PTHR24240:SF180 OPSIN LONG-WAVE-SENSITIVE OPSIN 1 molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;response to abiotic stimulus#GO:0009628;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;response to light stimulus#GO:0009416;cellular response to environmental stimulus#GO:0104004;regulation of cellular process#GO:0050794;cellular response to radiation#GO:0071478;signaling#GO:0023052;cellular response to abiotic stimulus#GO:0071214;response to external stimulus#GO:0009605;detection of stimulus#GO:0051606;signal transduction#GO:0007165;response to radiation#GO:0009314;cellular process#GO:0009987;cellular response to light stimulus#GO:0071482;biological regulation#GO:0065007 cilium#GO:0005929;non-motile cilium#GO:0097730;membrane-bounded organelle#GO:0043227;cell periphery#GO:0071944;photoreceptor cell cilium#GO:0097733;neuron projection#GO:0043005;membrane#GO:0016020;9+0 non-motile cilium#GO:0097731;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;photoreceptor outer segment#GO:0001750;organelle#GO:0043226 G-protein coupled receptor#PC00021 HUMAN|HGNC=1664|UniProtKB=Q8WTV0 Q8WTV0 SCARB1 PTHR11923:SF110 SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1 SCAVENGER RECEPTOR CLASS B MEMBER 1 protein-containing complex binding#GO:0044877;lipid binding#GO:0008289;cargo receptor activity#GO:0038024;protein-lipid complex binding#GO:0071814;low-density lipoprotein particle binding#GO:0030169;binding#GO:0005488;lipoprotein particle binding#GO:0071813 endocytosis#GO:0006897;regulation of biological process#GO:0050789;localization#GO:0051179;organic hydroxy compound transport#GO:0015850;lipid localization#GO:0010876;cell recognition#GO:0008037;multicellular organismal process#GO:0032501;lipid transport#GO:0006869;biological regulation#GO:0065007;cholesterol transport#GO:0030301;macromolecule localization#GO:0033036;cholesterol efflux#GO:0033344;cellular process#GO:0009987;sterol transport#GO:0015918;plasma lipoprotein particle clearance#GO:0034381;import into cell#GO:0098657;establishment of localization#GO:0051234;apoptotic cell clearance#GO:0043277;phagocytosis#GO:0006909;transport#GO:0006810 caveola#GO:0005901;membrane raft#GO:0045121;membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane region#GO:0098590;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane microdomain#GO:0098857;plasma membrane raft#GO:0044853 membrane traffic protein#PC00150;membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=6905|UniProtKB=Q9NZL9 Q9NZL9 MAT2B PTHR10491:SF6 DTDP-4-DEHYDRORHAMNOSE REDUCTASE METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234 metabolic process#GO:0008152;sulfur compound metabolic process#GO:0006790;cellular process#GO:0009987;biosynthetic process#GO:0009058 intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;transferase complex#GO:1990234 reductase#PC00198 O-antigen biosynthesis#P02757>dTDP-4-dehydrorhamnose reductase#P03050 HUMAN|HGNC=16123|UniProtKB=Q9NT22 Q9NT22 EMILIN3 PTHR15427:SF2 EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER EMILIN-3 supramolecular complex#GO:0099080;interstitial matrix#GO:0005614;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;protein complex involved in cell adhesion#GO:0098636;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;supramolecular fiber#GO:0099512;extracellular protein-containing complex#GO:0140392;extracellular region#GO:0005576 scaffold/adaptor protein#PC00226 HUMAN|HGNC=24669|UniProtKB=Q6QHK4 Q6QHK4 FIGLA PTHR23349:SF57 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST FACTOR IN THE GERMLINE ALPHA DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=18935|UniProtKB=Q8IUC2 Q8IUC2 KRTAP8-1 PTHR36131:SF1 KERATIN-ASSOCIATED PROTEIN 8-1 KERATIN-ASSOCIATED PROTEIN 8-1 structural protein#PC00211 HUMAN|HGNC=21207|UniProtKB=Q7L985 Q7L985 LINGO2 PTHR24373:SF38 SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN LEUCINE-RICH REPEAT AND IMMUNOGLOBULIN-LIKE DOMAIN-CONTAINING NOGO RECEPTOR-INTERACTING PROTEIN 2 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=11582|UniProtKB=Q15813 Q15813 TBCE PTHR15140:SF31 TUBULIN-SPECIFIC CHAPERONE E TUBULIN-SPECIFIC CHAPERONE E tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;protein binding#GO:0005515 cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226;protein-containing complex organization#GO:0043933;microtubule-based process#GO:0007017;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 chaperone#PC00072 HUMAN|HGNC=130|UniProtKB=P62736 P62736 ACTA2 PTHR11937:SF445 ACTIN ACTIN, AORTIC SMOOTH MUSCLE structural molecule activity#GO:0005198;structural constituent of cytoskeleton#GO:0005200 intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;actin cytoskeleton#GO:0015629;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 actin and actin related protein#PC00039 Cadherin signaling pathway#P00012>F-actin#P00470;Wnt signaling pathway#P00057>NFAT Target Genes#G01559;Alzheimer disease-presenilin pathway#P00004>actin#P00114;Cytoskeletal regulation by Rho GTPase#P00016>Actin#P00512;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>F-actin#P00858;Nicotinic acetylcholine receptor signaling pathway#P00044>Actin#P01090;Huntington disease#P00029>Actin#P00807;Integrin signalling pathway#P00034>Actin#P00944 HUMAN|HGNC=1751|UniProtKB=P55289 P55289 CDH12 PTHR24027:SF96 CADHERIN-23 CADHERIN-12 binding#GO:0005488;cell adhesion molecule binding#GO:0050839;protein binding#GO:0005515;beta-catenin binding#GO:0008013 cellular component biogenesis#GO:0044085;cell-cell adhesion#GO:0098609;cellular process#GO:0009987;cellular component assembly#GO:0022607;cell migration#GO:0016477;cell-cell junction organization#GO:0045216;developmental process#GO:0032502;cell-cell junction assembly#GO:0007043;cellular component organization or biogenesis#GO:0071840;cell junction assembly#GO:0034329;adherens junction organization#GO:0034332;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cell morphogenesis#GO:0000902;cell motility#GO:0048870;cell junction organization#GO:0034330;cell adhesion#GO:0007155;anatomical structure development#GO:0048856 membrane#GO:0016020;cell-cell junction#GO:0005911;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;extrinsic component of plasma membrane#GO:0019897;extrinsic component of membrane#GO:0019898;cell junction#GO:0030054;anchoring junction#GO:0070161;adherens junction#GO:0005912 cadherin#PC00057;cell adhesion molecule#PC00069 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HUMAN|HGNC=4657|UniProtKB=Q13889 Q13889 GTF2H3 PTHR12831:SF0 TRANSCRIPTION INITIATION FACTOR IIH TFIIH , POLYPEPTIDE 3-RELATED GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3 response to stress#GO:0006950;transcription initiation at RNA polymerase II promoter#GO:0006367;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;nucleotide-excision repair#GO:0006289;DNA metabolic process#GO:0006259;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA damage response#GO:0006974;transcription by RNA polymerase II#GO:0006366;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular response to stimulus#GO:0051716;DNA-templated transcription initiation#GO:0006352;response to stimulus#GO:0050896;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;cellular response to stress#GO:0033554;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070 transcription factor TFIIH core complex#GO:0000439;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;transcription regulator complex#GO:0005667;intracellular protein-containing complex#GO:0140535;protein kinase complex#GO:1902911;membrane-enclosed lumen#GO:0031974;RNA polymerase II transcription regulator complex#GO:0090575;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;protein-containing complex#GO:0032991;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;transcription factor TFIIH holo complex#GO:0005675;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;RNA polymerase II, holoenzyme#GO:0016591;membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231 RNA metabolism protein#PC00031;general transcription factor#PC00259 Transcription regulation by bZIP transcription factor#P00055>TFIIH complex#P01392;General transcription regulation#P00023>TFIIH complex#P00664 HUMAN|HGNC=17333|UniProtKB=Q8NEY3 Q8NEY3 SPATA4 PTHR12509:SF8 SPERMATOGENESIS-ASSOCIATED 4-RELATED SPERMATOGENESIS-ASSOCIATED PROTEIN 4 cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;microtubule binding#GO:0008017;binding#GO:0005488;protein binding#GO:0005515 regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043 membraneless organelle#GO:0043228;axoneme#GO:0005930;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;cilium#GO:0005929;ciliary plasm#GO:0097014;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232 HUMAN|HGNC=3008|UniProtKB=Q9NY33 Q9NY33 DPP3 PTHR23422:SF11 DIPEPTIDYL PEPTIDASE III-RELATED DIPEPTIDYL PEPTIDASE 3 protease#PC00190;metalloprotease#PC00153 HUMAN|HGNC=29153|UniProtKB=Q8TBE0 Q8TBE0 BAHD1 PTHR46576:SF1 BROMO ADJACENT HOMOLOGY DOMAIN-CONTAINING 1 PROTEIN BROMO ADJACENT HOMOLOGY DOMAIN-CONTAINING 1 PROTEIN sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;chromatin binding#GO:0003682;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677 heterochromatin organization#GO:0070828;cellular component assembly#GO:0022607;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;negative regulation of gene expression, epigenetic#GO:0045814;cellular component organization or biogenesis#GO:0071840;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;epigenetic regulation of gene expression#GO:0040029;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of cellular process#GO:0048523;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;heterochromatin formation#GO:0031507;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355 nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=11754|UniProtKB=O14948 O14948 TFEC PTHR45776:SF1 MIP04163P TRANSCRIPTION FACTOR EC RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264;basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=15888|UniProtKB=Q9NZ71 Q9NZ71 RTEL1 PTHR11472:SF62 DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER REGULATOR OF TELOMERE ELONGATION HELICASE 1 ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;nucleic acid conformation isomerase activity#GO:0120545;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;DNA helicase activity#GO:0003678;catalytic activity, acting on DNA#GO:0140097;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;ATP-dependent activity#GO:0140657;enzyme binding#GO:0019899;nucleoside phosphate binding#GO:1901265;ATP binding#GO:0005524;binding#GO:0005488;ATP-dependent activity, acting on DNA#GO:0008094;protein binding#GO:0005515;macromolecular conformation isomerase activity#GO:0120543;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;nucleotide binding#GO:0000166;isomerase activity#GO:0016853;helicase activity#GO:0004386;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094 regulation of DNA recombination#GO:0000018;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of cellular response to stress#GO:0080135;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;regulation of organelle organization#GO:0033043;regulation of DNA metabolic process#GO:0051052;regulation of biological process#GO:0050789;regulation of cellular component organization#GO:0051128;regulation of double-strand break repair via homologous recombination#GO:0010569;regulation of cellular component biogenesis#GO:0044087;negative regulation of metabolic process#GO:0009892;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;organelle organization#GO:0006996;cellular process#GO:0009987;regulation of double-strand break repair#GO:2000779;telomere organization#GO:0032200;negative regulation of DNA recombination#GO:0045910;nucleic acid metabolic process#GO:0090304;negative regulation of cellular component organization#GO:0051129;primary metabolic process#GO:0044238;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of cellular process#GO:0048523;regulation of chromosome organization#GO:0033044;regulation of response to stress#GO:0080134;regulation of DNA repair#GO:0006282;regulation of response to stimulus#GO:0048583;macromolecule metabolic process#GO:0043170;chromosome organization#GO:0051276;regulation of telomere maintenance#GO:0032204;telomere maintenance#GO:0000723;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of DNA metabolic process#GO:0051053;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 DNA helicase#PC00011;DNA metabolism protein#PC00009 HUMAN|HGNC=30897|UniProtKB=Q96JH7 Q96JH7 VCPIP1 PTHR14843:SF2 DEUBIQUITINATING PROTEIN VCIP135 DEUBIQUITINATING PROTEIN VCPIP1 ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;cysteine-type peptidase activity#GO:0008234;cysteine-type deubiquitinase activity#GO:0004843;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005 nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;endoplasmic reticulum organization#GO:0007029;Golgi organization#GO:0007030;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;response to stress#GO:0006950;organelle organization#GO:0006996;membrane fusion#GO:0061025;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cellular component assembly#GO:0022607;organelle fusion#GO:0048284;organelle membrane fusion#GO:0090174;membrane organization#GO:0061024;endomembrane system organization#GO:0010256;nucleobase-containing compound metabolic process#GO:0006139;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;endoplasmic reticulum membrane organization#GO:0090158;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840 cysteine protease#PC00081;protease#PC00190 HUMAN|HGNC=7473|UniProtKB=Q9UBK8 Q9UBK8 MTRR PTHR19384:SF84 NITRIC OXIDE SYNTHASE-RELATED METHIONINE SYNTHASE REDUCTASE carbohydrate derivative binding#GO:0097367;catalytic activity#GO:0003824;ribonucleotide binding#GO:0032553;heterocyclic compound binding#GO:1901363;oxidoreductase activity#GO:0016491;nucleotide binding#GO:0000166;oxidoreductase activity, acting on metal ions#GO:0016722;nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167;small molecule binding#GO:0036094;flavin adenine dinucleotide binding#GO:0050660;anion binding#GO:0043168;binding#GO:0005488 metabolic process#GO:0008152;amino acid biosynthetic process#GO:0008652;small molecule biosynthetic process#GO:0044283;proteinogenic amino acid biosynthetic process#GO:0170038;sulfur compound metabolic process#GO:0006790;aspartate family amino acid biosynthetic process#GO:0009067;homocysteine metabolic process#GO:0050667;cellular process#GO:0009987;proteinogenic amino acid metabolic process#GO:0170039;biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;oxoacid metabolic process#GO:0043436;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;carboxylic acid biosynthetic process#GO:0046394;small molecule metabolic process#GO:0044281 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=32|UniProtKB=Q9BZC7 Q9BZC7 ABCA2 PTHR19229:SF275 ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 2 primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657 transport#GO:0006810;lipid localization#GO:0010876;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;lipid transport#GO:0006869;localization#GO:0051179 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 ATP-binding cassette (ABC) transporter#PC00003 HUMAN|HGNC=15478|UniProtKB=Q9BZ11 Q9BZ11 ADAM33 PTHR11905:SF38 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 33 metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 primary metabolic process#GO:0044238;proteolysis#GO:0006508;metabolic process#GO:0008152;cellular process#GO:0009987;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 protease#PC00190;metalloprotease#PC00153 HUMAN|HGNC=1811|UniProtKB=Q9Y232 Q9Y232 CDYL PTHR43684:SF5 FAMILY NOT NAMED CHROMODOMAIN Y-LIKE PROTEIN transcription corepressor activity#GO:0003714;catalytic activity#GO:0003824;transcription coregulator activity#GO:0003712;molecular adaptor activity#GO:0060090;histone H3K9me2/3 reader activity#GO:0062072;histone reader activity#GO:0140566;intramolecular oxidoreductase activity#GO:0016860;isomerase activity#GO:0016853;chromatin-protein adaptor activity#GO:0140463;protein-macromolecule adaptor activity#GO:0030674;histone H3 reader activity#GO:0140006;transcription regulator activity#GO:0140110 male gamete generation#GO:0048232;monocarboxylic acid catabolic process#GO:0072329;carboxylic acid catabolic process#GO:0046395;lipid modification#GO:0030258;cellular developmental process#GO:0048869;fatty acid metabolic process#GO:0006631;spermatogenesis#GO:0007283;developmental process#GO:0032502;lipid metabolic process#GO:0006629;fatty acid beta-oxidation#GO:0006635;catabolic process#GO:0009056;reproductive process#GO:0022414;developmental process involved in reproduction#GO:0003006;primary metabolic process#GO:0044238;germ cell development#GO:0007281;anatomical structure development#GO:0048856;lipid oxidation#GO:0034440;multicellular organismal reproductive process#GO:0048609;sexual reproduction#GO:0019953;spermatid development#GO:0007286;lipid catabolic process#GO:0016042;cellular process#GO:0009987;metabolic process#GO:0008152;fatty acid oxidation#GO:0019395;small molecule metabolic process#GO:0044281;cell differentiation#GO:0030154;gamete generation#GO:0007276;cell development#GO:0048468;cellular process involved in reproduction in multicellular organism#GO:0022412;small molecule catabolic process#GO:0044282;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;fatty acid catabolic process#GO:0009062;oxoacid metabolic process#GO:0043436;spermatid differentiation#GO:0048515 membrane-bounded organelle#GO:0043227;peroxisomal matrix#GO:0005782;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microbody#GO:0042579;nucleus#GO:0005634;peroxisome#GO:0005777;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233 HUMAN|HGNC=26950|UniProtKB=Q1ZYL8 Q1ZYL8 IZUMO4 PTHR37357:SF1 IZUMO SPERM-EGG FUSION PROTEIN 4 IZUMO SPERM-EGG FUSION PROTEIN 4 HUMAN|HGNC=26084|UniProtKB=Q7Z2X4 Q7Z2X4 PID1 PTHR16265:SF1 PTB-CONTAINING, CUBILIN AND LRP1-INTERACTING PROTEIN PTB-CONTAINING, CUBILIN AND LRP1-INTERACTING PROTEIN regulation of cellular process#GO:0050794;negative regulation of transport#GO:0051051;biological regulation#GO:0065007;regulation of transmembrane transport#GO:0034762;regulation of metabolic process#GO:0019222;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of localization#GO:0032879;regulation of transport#GO:0051049;negative regulation of cellular process#GO:0048523;regulation of reactive oxygen species metabolic process#GO:2000377 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=11881|UniProtKB=P62328 P62328 TMSB4X PTHR12021:SF20 THYMOSIN BETA THYMOSIN BETA-4 protein binding#GO:0005515;molecular sequestering activity#GO:0140313;binding#GO:0005488;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;protein sequestering activity#GO:0140311;actin monomer binding#GO:0003785 regulation of locomotion#GO:0040012;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of cell motility#GO:2000145;regulation of biological process#GO:0050789;regulation of cell migration#GO:0030334 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=21051|UniProtKB=Q9UGC7 Q9UGC7 MTRF1L PTHR43804:SF3 LD18447P PEPTIDE CHAIN RELEASE FACTOR 1-LIKE, MITOCHONDRIAL cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-containing complex organization#GO:0043933;metabolic process#GO:0008152;gene expression#GO:0010467;biosynthetic process#GO:0009058;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein metabolic process#GO:0019538;cellular component disassembly#GO:0022411;mitochondrial gene expression#GO:0140053;translational termination#GO:0006415;translation#GO:0006412;mitochondrial translation#GO:0032543;protein biosynthetic process#GO:0160307;protein-containing complex disassembly#GO:0032984;primary metabolic process#GO:0044238;cellular component organization#GO:0016043 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 translation factor#PC00223;translational protein#PC00263;translation release factor#PC00225 HUMAN|HGNC=30620|UniProtKB=Q9GZP0 Q9GZP0 PDGFD PTHR11633:SF4 PLATELET-DERIVED GROWTH FACTOR PLATELET-DERIVED GROWTH FACTOR D binding#GO:0005488;signaling receptor binding#GO:0005102;growth factor receptor binding#GO:0070851;protein binding#GO:0005515 regulation of biological process#GO:0050789;positive regulation of cell motility#GO:2000147;positive regulation of cell population proliferation#GO:0008284;signaling#GO:0023052;response to stimulus#GO:0050896;positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051897;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;positive regulation of signaling#GO:0023056;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;regulation of ERK1 and ERK2 cascade#GO:0070372;cell surface receptor signaling pathway#GO:0007166;regulation of MAPK cascade#GO:0043408;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;positive regulation of ERK1 and ERK2 cascade#GO:0070374;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051896;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;regulation of cell motility#GO:2000145;positive regulation of cell migration#GO:0030335;positive regulation of cellular process#GO:0048522;regulation of locomotion#GO:0040012;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;regulation of response to stimulus#GO:0048583;regulation of cell migration#GO:0030334;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of locomotion#GO:0040017;positive regulation of MAPK cascade#GO:0043410 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 growth factor#PC00112 Angiogenesis#P00005>PDGF#P00224 HUMAN|HGNC=4506|UniProtKB=Q13585 Q13585 GPR50 PTHR24228:SF56 B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR MELATONIN-RELATED RECEPTOR transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711 HUMAN|HGNC=6718|UniProtKB=P36941 P36941 LTBR PTHR47607:SF1 TUMOR NECROSIS FACTOR RECEPTOR SUBFAMILY MEMBER 3 TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 3 protein binding#GO:0005515;ubiquitin protein ligase binding#GO:0031625;ubiquitin-like protein ligase binding#GO:0044389;binding#GO:0005488;enzyme binding#GO:0019899 positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;positive regulation of canonical NF-kappaB signal transduction#GO:0043123;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of canonical NF-kappaB signal transduction#GO:0043122;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;positive regulation of signaling#GO:0023056;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647 transmembrane signal receptor#PC00197 HUMAN|HGNC=29653|UniProtKB=Q7L3S4 Q7L3S4 ZNF771 PTHR24394:SF63 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 771 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110 regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=34351|UniProtKB=A1L170 A1L170 C1orf226 PTHR11232:SF45 PHOSPHOTYROSINE INTERACTION DOMAIN-CONTAINING FAMILY MEMBER GENE 7694-RELATED receptor tyrosine kinase binding#GO:0030971;molecular adaptor activity#GO:0060090;signaling receptor complex adaptor activity#GO:0030159;protein kinase binding#GO:0019901;transmembrane receptor protein tyrosine kinase adaptor activity#GO:0005068;enzyme binding#GO:0019899;protein-macromolecule adaptor activity#GO:0030674;kinase binding#GO:0019900;signaling receptor binding#GO:0005102;protein tyrosine kinase binding#GO:1990782;binding#GO:0005488;protein binding#GO:0005515;signaling adaptor activity#GO:0035591 regulation of multicellular organismal development#GO:2000026;regulation of cell development#GO:0060284;regulation of biological process#GO:0050789;regulation of neurogenesis#GO:0050767;regulation of multicellular organismal process#GO:0051239;regulation of developmental process#GO:0050793;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of cell differentiation#GO:0045595;regulation of nervous system development#GO:0051960 basolateral plasma membrane#GO:0016323;basal part of cell#GO:0045178;membrane#GO:0016020;basal plasma membrane#GO:0009925;cell periphery#GO:0071944;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 Notch signaling pathway#P00045>Numb#P01118 HUMAN|HGNC=2255|UniProtKB=Q92828 Q92828 CORO2A PTHR10856:SF2 CORONIN CORONIN-2A protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;actin filament binding#GO:0051015 cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;actin filament-based process#GO:0030029;actin filament organization#GO:0007015;supramolecular fiber organization#GO:0097435;cellular component organization or biogenesis#GO:0071840 actin cytoskeleton#GO:0015629;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;actin filament#GO:0005884;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513 cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HUMAN|HGNC=20675|UniProtKB=Q96KN2 Q96KN2 CNDP1 PTHR43270:SF1 BETA-ALA-HIS DIPEPTIDASE BETA-ALA-HIS DIPEPTIDASE peptidase activity#GO:0008233;exopeptidase activity#GO:0008238;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;catalytic activity#GO:0003824 primary metabolic process#GO:0044238;proteolysis#GO:0006508;metabolic process#GO:0008152;cellular process#GO:0009987;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 metalloprotease#PC00153 HUMAN|HGNC=9914|UniProtKB=P0DJD4 P0DJD4 RBMY1C PTHR48034:SF17 TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED RNA-BINDING MOTIF PROTEIN, Y CHROMOSOME, FAMILY 1 MEMBER A1-RELATED mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070 ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;spliceosomal complex#GO:0005681;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231 RNA metabolism protein#PC00031 HUMAN|HGNC=17108|UniProtKB=Q8TE57 Q8TE57 ADAMTS16 PTHR13723:SF140 ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 16 catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222 primary metabolic process#GO:0044238;cellular component organization#GO:0016043;cellular process#GO:0009987;proteolysis#GO:0006508;metabolic process#GO:0008152;extracellular structure organization#GO:0043062;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;extracellular matrix organization#GO:0030198;external encapsulating structure organization#GO:0045229 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 metalloprotease#PC00153 HUMAN|HGNC=15606|UniProtKB=Q9UHA4 Q9UHA4 LAMTOR3 PTHR13378:SF3 REGULATOR COMPLEX PROTEIN LAMTOR3 RAGULATOR COMPLEX PROTEIN LAMTOR3 positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;regulation of TORC1 signaling#GO:1903432;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;response to acid chemical#GO:0001101;regulation of TOR signaling#GO:0032006;cellular process#GO:0009987;positive regulation of TORC1 signaling#GO:1904263;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of response to stimulus#GO:0048584;response to chemical#GO:0042221;regulation of signaling#GO:0023051;cellular response to chemical stimulus#GO:0070887;regulation of intracellular signal transduction#GO:1902531;positive regulation of TOR signaling#GO:0032008;positive regulation of signaling#GO:0023056;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;response to stimulus#GO:0050896;cellular response to amino acid stimulus#GO:0071230;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794 organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;intracellular protein-containing complex#GO:0140535;vacuolar membrane#GO:0005774;membrane#GO:0016020;cytoplasm#GO:0005737;vacuole#GO:0005773;protein-containing complex#GO:0032991;guanyl-nucleotide exchange factor complex#GO:0032045;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 scaffold/adaptor protein#PC00226 HUMAN|Gene=L1RE1|UniProtKB=Q9UN81 Q9UN81 L1RE1 PTHR11505:SF218 L1 TRANSPOSABLE ELEMENT-RELATED LINE-1 RETROTRANSPOSABLE ELEMENT ORF1 PROTEIN cellular process#GO:0009987 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991 viral or transposable element protein#PC00237 HUMAN|HGNC=6305|UniProtKB=P33947 P33947 KDELR2 PTHR10585:SF37 ER LUMEN PROTEIN RETAINING RECEPTOR ER LUMEN PROTEIN-RETAINING RECEPTOR 2 signal sequence receptor activity#GO:0005048 macromolecule localization#GO:0033036;cellular process#GO:0009987;localization#GO:0051179;protein localization to organelle#GO:0033365;cellular localization#GO:0051641;intracellular protein localization#GO:0008104 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cis-Golgi network#GO:0005801;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=17581|UniProtKB=Q96GX9 Q96GX9 APIP PTHR10640:SF7 METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE catalytic activity#GO:0003824;hydro-lyase activity#GO:0016836;carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829 nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;proteinogenic amino acid metabolic process#GO:0170039;amino acid metabolic process#GO:0006520;nucleobase-containing compound metabolic process#GO:0006139;sulfur compound metabolic process#GO:0006790;homocysteine metabolic process#GO:0050667;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;oxoacid metabolic process#GO:0043436;purine nucleoside metabolic process#GO:0042278;nucleoside metabolic process#GO:0009116;small molecule metabolic process#GO:0044281;carboxylic acid metabolic process#GO:0019752;modified amino acid metabolic process#GO:0006575;primary metabolic process#GO:0044238;purine-containing compound metabolic process#GO:0072521 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 metabolite interconversion enzyme#PC00262;dehydratase#PC00091 HUMAN|HGNC=14809|UniProtKB=Q8NGN3 Q8NGN3 OR10G4 PTHR26453:SF6 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 10G4-RELATED olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 system process#GO:0003008;sensory perception#GO:0007600;nervous system process#GO:0050877;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;response to chemical#GO:0042221;response to stimulus#GO:0050896;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;detection of chemical stimulus#GO:0009593;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=30541|UniProtKB=A8K979 A8K979 ERI2 PTHR23044:SF84 3'-5' EXONUCLEASE ERI1-RELATED ERI1 EXORIBONUCLEASE 2 catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on RNA#GO:0140098;3'-5' exonuclease activity#GO:0008408;RNA nuclease activity#GO:0004540;exonuclease activity#GO:0004527;3'-5'-RNA exonuclease activity#GO:0000175;hydrolase activity#GO:0016787;nuclease activity#GO:0004518 RNA metabolic process#GO:0016070;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;ribonucleoprotein complex biogenesis#GO:0022613;maturation of 5.8S rRNA#GO:0000460;regulation of gene silencing by regulatory ncRNA#GO:0060966;regulation of cellular component organization#GO:0051128;regulation of biological process#GO:0050789;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;negative regulation of biological process#GO:0048519;RNA 3'-end processing#GO:0031123;cellular component organization or biogenesis#GO:0071840;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA processing#GO:0006396;gene expression#GO:0010467;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;cellular component biogenesis#GO:0044085;rRNA processing#GO:0006364;positive regulation of biosynthetic process#GO:0009891;regulation of chromatin organization#GO:1902275;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;negative regulation of cellular component organization#GO:0051129;regulation of gene expression#GO:0010468;positive regulation of gene expression#GO:0010628;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;negative regulation of cellular process#GO:0048523;rRNA metabolic process#GO:0016072;biosynthetic process#GO:0009058;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;macromolecule biosynthetic process#GO:0009059;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 exoribonuclease#PC00099 HUMAN|HGNC=15739|UniProtKB=O75901 O75901 RASSF9 PTHR15286:SF10 RAS-ASSOCIATING DOMAIN CONTAINING PROTEIN RAS ASSOCIATION DOMAIN-CONTAINING PROTEIN 9 intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;coated vesicle membrane#GO:0030662;Golgi-associated vesicle membrane#GO:0030660;trans-Golgi network transport vesicle#GO:0030140;endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;coated vesicle#GO:0030135;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;vesicle membrane#GO:0012506;cytosol#GO:0005829;transport vesicle membrane#GO:0030658;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;transport vesicle#GO:0030133;cytoplasm#GO:0005737;clathrin-coated vesicle#GO:0030136;trans-Golgi network transport vesicle membrane#GO:0012510;recycling endosome#GO:0055037;Golgi-associated vesicle#GO:0005798;clathrin-coated vesicle membrane#GO:0030665;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090 scaffold/adaptor protein#PC00226 HUMAN|HGNC=10586|UniProtKB=Q07699 Q07699 SCN1B PTHR10546:SF2 SODIUM CHANNEL SUBUNIT BETA-1 AND 3 SODIUM CHANNEL REGULATORY SUBUNIT BETA-1 binding#GO:0005488;transporter regulator activity#GO:0141108;transmembrane transporter binding#GO:0044325;protein binding#GO:0005515;molecular function inhibitor activity#GO:0140678;channel regulator activity#GO:0016247;ion channel inhibitor activity#GO:0008200;ion channel regulator activity#GO:0099106;molecular function regulator activity#GO:0098772 cardiac muscle cell contraction#GO:0086003;establishment of localization#GO:0051234;heart contraction#GO:0060047;system process#GO:0003008;regulation of system process#GO:0044057;transport#GO:0006810;muscle contraction#GO:0006936;multicellular organismal process#GO:0032501;blood circulation#GO:0008015;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;actin filament-based movement#GO:0030048;localization#GO:0051179;monoatomic cation transport#GO:0006812;circulatory system process#GO:0003013;actin filament-based process#GO:0030029;cardiac muscle contraction#GO:0060048;actin-mediated cell contraction#GO:0070252;regulation of heart contraction#GO:0008016;striated muscle contraction#GO:0006941;membrane depolarization#GO:0051899;metal ion transport#GO:0030001;regulation of membrane potential#GO:0042391;cardiac muscle cell action potential involved in contraction#GO:0086002;regulation of multicellular organismal process#GO:0051239;monoatomic cation transmembrane transport#GO:0098655;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;transmembrane transport#GO:0055085;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;sodium ion transport#GO:0006814;heart process#GO:0003015;muscle system process#GO:0003012;regulation of biological process#GO:0050789;action potential#GO:0001508 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;membrane#GO:0016020;sodium channel complex#GO:0034706;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;cation channel complex#GO:0034703 ion channel#PC00133;voltage-gated ion channel#PC00241 HUMAN|HGNC=19656|UniProtKB=Q7RTM1 Q7RTM1 OTOP1 PTHR21522:SF19 PROTON CHANNEL OTOP PROTON CHANNEL OTOP1 binding#GO:0005488;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;protein binding#GO:0005515;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;proton transmembrane transporter activity#GO:0015078;passive transmembrane transporter activity#GO:0022803;proton channel activity#GO:0015252;identical protein binding#GO:0042802;monoatomic cation channel activity#GO:0005261;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 multicellular organismal process#GO:0032501;tissue development#GO:0009888;embryo development#GO:0009790;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;inner ear development#GO:0048839;inner ear morphogenesis#GO:0042472;cellular process#GO:0009987;animal organ development#GO:0048513;establishment of localization#GO:0051234;multicellular organism development#GO:0007275;proton transmembrane transport#GO:1902600;embryonic morphogenesis#GO:0048598;anatomical structure formation involved in morphogenesis#GO:0048646;sensory organ development#GO:0007423;transport#GO:0006810;developmental process#GO:0032502;animal organ morphogenesis#GO:0009887;sensory organ morphogenesis#GO:0090596;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;ear development#GO:0043583;monoatomic ion transport#GO:0006811;animal gross anatomical part developmental process#GO:0160108;embryonic organ development#GO:0048568;biomineral tissue development#GO:0031214 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227 HUMAN|HGNC=3036|UniProtKB=Q02487 Q02487 DSC2 PTHR24025:SF0 DESMOGLEIN FAMILY MEMBER DESMOCOLLIN-2 small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;calcium ion binding#GO:0005509;metal ion binding#GO:0046872;cation binding#GO:0043169 cell-cell adhesion#GO:0098609;cellular process#GO:0009987;cell adhesion#GO:0007155 cell-cell junction#GO:0005911;anchoring junction#GO:0070161;cellular anatomical structure#GO:0110165;cell junction#GO:0030054 cadherin#PC00057 HUMAN|HGNC=29829|UniProtKB=Q6DT37 Q6DT37 CDC42BPG PTHR22988:SF22 MYOTONIC DYSTROPHY S/T KINASE-RELATED SERINE_THREONINE-PROTEIN KINASE MRCK GAMMA catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;actin cytoskeleton organization#GO:0030036;cytoskeleton organization#GO:0007010;actomyosin structure organization#GO:0031032;actin filament-based process#GO:0030029;cellular component organization or biogenesis#GO:0071840 actin cytoskeleton#GO:0015629;actomyosin#GO:0042641;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=5526|UniProtKB=P01859 P01859 IGHG2 PTHR23411:SF39 TAPASIN IMMUNOGLOBULIN HEAVY CONSTANT GAMMA 1-RELATED protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102;antigen binding#GO:0003823 positive regulation of immune system process#GO:0002684;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;positive regulation of biological process#GO:0048518;defense response to symbiont#GO:0140546;activation of immune response#GO:0002253;defense response to other organism#GO:0098542;humoral immune response#GO:0006959;antimicrobial humoral response#GO:0019730;immune effector process#GO:0002252;antibacterial humoral response#GO:0019731;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;immune system process#GO:0002376;defense response to bacterium#GO:0042742;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;immune response#GO:0006955;complement activation#GO:0006956;positive regulation of response to stimulus#GO:0048584;response to other organism#GO:0051707;adaptive immune response#GO:0002250;biological regulation#GO:0065007;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;defense response#GO:0006952;response to external stimulus#GO:0009605;regulation of immune system process#GO:0002682;response to external biotic stimulus#GO:0043207;response to bacterium#GO:0009617;regulation of immune response#GO:0050776 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;extracellular region#GO:0005576;extracellular protein-containing complex#GO:0140392 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=16058|UniProtKB=Q9BYT8 Q9BYT8 NLN PTHR11804:SF44 PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED NEUROLYSIN, MITOCHONDRIAL catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;mitochondrion#GO:0005739 protease#PC00190;metalloprotease#PC00153 HUMAN|HGNC=1630|UniProtKB=P48509 P48509 CD151 PTHR19282:SF487 TETRASPANIN CD151 ANTIGEN cell motility#GO:0048870;cell migration#GO:0016477;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HUMAN|HGNC=7521|UniProtKB=Q9HBB8 Q9HBB8 CDHR5 PTHR24028:SF243 CADHERIN-87A CADHERIN-RELATED FAMILY MEMBER 5 cell adhesion#GO:0007155;cellular process#GO:0009987;cell-cell adhesion#GO:0098609 membrane#GO:0016020;cell periphery#GO:0071944;cell junction#GO:0030054;synapse#GO:0045202;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cadherin#PC00057;cell adhesion molecule#PC00069 HUMAN|HGNC=15938|UniProtKB=Q9NWZ5 Q9NWZ5 UCKL1 PTHR10285:SF68 URIDINE KINASE URIDINE-CYTIDINE KINASE-LIKE 1 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 nucleotide kinase#PC00172;kinase#PC00137 Salvage pyrimidine ribonucleotides#P02775>Cytidine kinase#P03149;Salvage pyrimidine ribonucleotides#P02775>Uridine kinase#P03150 HUMAN|HGNC=14064|UniProtKB=Q9UBN7 Q9UBN7 HDAC6 PTHR10625:SF21 HISTONE DEACETYLASE HDAC1-RELATED PROTEIN DEACETYLASE HDAC6 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;histone modifying activity#GO:0140993;hydrolase activity#GO:0016787;deacetylase activity#GO:0019213;catalytic activity#GO:0003824;histone deacetylase activity#GO:0004407;deacylase activity#GO:0160215;catalytic activity, acting on a protein#GO:0140096;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810 regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;neuron differentiation#GO:0030182;developmental process#GO:0032502;biological regulation#GO:0065007;chromatin organization#GO:0006325;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;cellular process#GO:0009987;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;epigenetic regulation of gene expression#GO:0040029;system development#GO:0048731;anatomical structure development#GO:0048856;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;chromatin remodeling#GO:0006338;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular component organization#GO:0016043 cytoplasm#GO:0005737;cytosol#GO:0005829 HUMAN|HGNC=29425|UniProtKB=Q8TF20 Q8TF20 ZNF721 PTHR24376:SF210 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 721-RELATED gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HUMAN|HGNC=21806|UniProtKB=Q8N393 Q8N393 ZNF786 PTHR24376:SF185 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 786 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=1632|UniProtKB=Q04900 Q04900 CD164 PTHR11337:SF12 MUCIN/PORIMIN SIALOMUCIN CORE PROTEIN 24 intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;vesicle#GO:0031982;intracellular vesicle#GO:0097708;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=13348|UniProtKB=Q14210 Q14210 LY6D PTHR16982:SF2 LYMPHOCYTE ANTIGEN 6D LYMPHOCYTE ANTIGEN 6D HUMAN|HGNC=27814|UniProtKB=A6NGR9 A6NGR9 MROH6 PTHR23120:SF40 MAESTRO-RELATED HEAT DOMAIN-CONTAINING MAESTRO HEAT-LIKE REPEAT-CONTAINING PROTEIN FAMILY MEMBER 6 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=9996|UniProtKB=O43566 O43566 RGS14 PTHR45945:SF2 REGULATOR OF G-PROTEIN SIGNALING LOCO REGULATOR OF G PROTEIN SIGNALING 14 enzyme activator activity#GO:0008047;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 positive regulation of synaptic transmission#GO:0050806;regulation of signaling#GO:0023051;nervous system process#GO:0050877;positive regulation of signaling#GO:0023056;regulation of biological quality#GO:0065008;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;cell cycle process#GO:0022402;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;organelle organization#GO:0006996;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of trans-synaptic signaling#GO:0099177;cytoskeleton organization#GO:0007010;cognition#GO:0050890;microtubule cytoskeleton organization#GO:0000226;cell cycle#GO:0007049;cell division#GO:0051301;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;regulation of synaptic plasticity#GO:0048167;regulation of G protein-coupled receptor signaling pathway#GO:0008277;regulation of response to stimulus#GO:0048583;spindle organization#GO:0007051;system process#GO:0003008;positive regulation of cellular process#GO:0048522;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966 cell periphery#GO:0071944;nucleus#GO:0005634;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>RGS#P00731;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>RGS#P00833;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>RGS#P00704 HUMAN|HGNC=9771|UniProtKB=Q13636 Q13636 RAB31 PTHR24073:SF588 DRAB5-RELATED RAS-RELATED PROTEIN RAB-31 catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111 establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule localization#GO:0033036;establishment of protein localization to membrane#GO:0090150;vesicle-mediated transport#GO:0016192;transport#GO:0006810;Golgi vesicle transport#GO:0048193;intracellular protein transport#GO:0006886;protein localization to cell periphery#GO:1990778;intracellular transport#GO:0046907;vesicle-mediated transport to the plasma membrane#GO:0098876;intracellular protein localization#GO:0008104;endosomal transport#GO:0016197;establishment of localization#GO:0051234;protein localization to membrane#GO:0072657;protein localization to plasma membrane#GO:0072659;Golgi to plasma membrane protein transport#GO:0043001;Golgi to plasma membrane transport#GO:0006893;localization within membrane#GO:0051668;establishment of protein localization to plasma membrane#GO:0061951;post-Golgi vesicle-mediated transport#GO:0006892;protein transport#GO:0015031;localization#GO:0051179;cellular localization#GO:0051641 cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;early endosome#GO:0005769;organelle subcompartment#GO:0031984;endosome#GO:0005768;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle membrane#GO:0031090;Golgi apparatus#GO:0005794;trans-Golgi network membrane#GO:0032588;endomembrane system#GO:0012505;late endosome#GO:0005770;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791 G-protein#PC00020;small GTPase#PC00208 HUMAN|HGNC=21091|UniProtKB=Q9Y4E5 Q9Y4E5 ZNF451 PTHR24408:SF61 ZINC FINGER PROTEIN E3 SUMO-PROTEIN LIGASE ZNF451 sequence-specific DNA binding#GO:0043565;transferase activity#GO:0016740;transcription corepressor activity#GO:0003714;ubiquitin-like protein ligase activity#GO:0061659;SUMO ligase activity#GO:0061665;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transcription coregulator activity#GO:0003712;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;SUMO transferase activity#GO:0019789;ubiquitin-like protein transferase activity#GO:0019787;nucleic acid binding#GO:0003676;acyltransferase activity#GO:0016746 macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;regulation of DNA-templated transcription#GO:0006355;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;protein modification process#GO:0036211;primary metabolic process#GO:0044238;regulation of DNA-templated transcription initiation#GO:2000142;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;post-translational protein modification#GO:0043687;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;protein modification by small protein conjugation or removal#GO:0070647;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;protein modification by small protein conjugation#GO:0032446;regulation of biological process#GO:0050789;protein sumoylation#GO:0016925;metabolic process#GO:0008152;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=13079|UniProtKB=Q96NJ3 Q96NJ3 ZNF285 PTHR24377:SF604 IP01015P-RELATED ZINC FINGER PROTEIN 285 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=17135|UniProtKB=Q8WXF3 Q8WXF3 RLN3 PTHR20968:SF0 ILGF DOMAIN-CONTAINING PROTEIN RELAXIN-3 receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;G protein-coupled receptor binding#GO:0001664;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;binding#GO:0005488;signaling receptor binding#GO:0005102;protein binding#GO:0005515;molecular function activator activity#GO:0140677 positive regulation of response to stimulus#GO:0048584;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;positive regulation of signal transduction#GO:0009967;positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789;positive regulation of cellular process#GO:0048522;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;regulation of G protein-coupled receptor signaling pathway#GO:0008277 HUMAN|HGNC=41982|UniProtKB=E9PJI5 E9PJI5 NPIPA7 PTHR15438:SF5 NUCLEAR PORE COMPLEX INTERACTING PROTEIN NUCLEAR PORE COMPLEX INTERACTING PROTEIN FAMILY MEMBER B3-RELATED HUMAN|HGNC=14786|UniProtKB=Q8NH54 Q8NH54 OR56A3 PTHR26450:SF40 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 56A3 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=15850|UniProtKB=Q96T49 Q96T49 PPP1R16B PTHR24179:SF31 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12 PROTEIN PHOSPHATASE 1 REGULATORY INHIBITOR SUBUNIT 16B enzyme inhibitor activity#GO:0004857;enzyme regulator activity#GO:0030234;phosphatase regulator activity#GO:0019208;molecular function regulator activity#GO:0098772;molecular function inhibitor activity#GO:0140678;protein phosphatase regulator activity#GO:0019888 regulation of biological process#GO:0050789;regulation of multicellular organismal development#GO:2000026;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;regulation of developmental process#GO:0050793;regulation of cell communication#GO:0010646;cell development#GO:0048468;animal gross anatomical part developmental process#GO:0160108;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;anatomical structure development#GO:0048856;regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051896;regulation of angiogenesis#GO:0045765;cellular process#GO:0009987;epithelium development#GO:0060429;tissue development#GO:0009888;epithelial cell differentiation#GO:0030855;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of multicellular organismal process#GO:0051239;regulation of vasculature development#GO:1901342;endothelial cell differentiation#GO:0045446;developmental process#GO:0032502;regulation of response to stimulus#GO:0048583;cellular developmental process#GO:0048869;regulation of anatomical structure morphogenesis#GO:0022603 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 phosphatase modulator#PC00184;protein-binding activity modulator#PC00095 HUMAN|HGNC=18626|UniProtKB=Q9BW83 Q9BW83 IFT27 PTHR47979:SF7 DRAB11-RELATED INTRAFLAGELLAR TRANSPORT PROTEIN 27 HOMOLOG purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;ribonucleotide binding#GO:0032553;hydrolase activity, acting on acid anhydrides#GO:0016817;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;guanyl nucleotide binding#GO:0019001;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;nucleoside phosphate binding#GO:1901265;ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleotide binding#GO:0000166;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;small molecule binding#GO:0036094;anion binding#GO:0043168;ion binding#GO:0043167;GTPase activity#GO:0003924 cellular component organization#GO:0016043;intraciliary transport#GO:0042073;cell projection organization#GO:0030030;microtubule-based movement#GO:0007018;microtubule-based transport#GO:0099111;cilium organization#GO:0044782;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle organization#GO:0006996;plasma membrane bounded cell projection organization#GO:0120036;vesicle-mediated transport#GO:0016192;cytoskeleton-dependent intracellular transport#GO:0030705;transport#GO:0006810;intracellular transport#GO:0046907;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;transport along microtubule#GO:0010970 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cilium#GO:0005929;intracellular organelle#GO:0043229;intraciliary transport particle#GO:0030990;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intraciliary transport particle B#GO:0030992;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;membrane#GO:0016020 small GTPase#PC00208;G-protein#PC00020 HUMAN|HGNC=23664|UniProtKB=Q5TCZ1 Q5TCZ1 SH3PXD2A PTHR15706:SF30 SH3 MULTIPLE DOMAIN SH3 AND PX DOMAIN-CONTAINING PROTEIN 2A enzyme activator activity#GO:0008047;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234 reactive oxygen species metabolic process#GO:0072593;metabolic process#GO:0008152;cellular process#GO:0009987;superoxide metabolic process#GO:0006801 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=24007|UniProtKB=Q5T9A4 Q5T9A4 ATAD3B PTHR23075:SF2 PUTATIVE ATP-ASE ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 3B cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;mitochondrion organization#GO:0007005;cellular component organization or biogenesis#GO:0071840 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739 HUMAN|HGNC=255|UniProtKB=P28332 P28332 ADH6 PTHR43880:SF20 ALCOHOL DEHYDROGENASE ALCOHOL DEHYDROGENASE 6 oxidoreductase activity#GO:0016491;alcohol dehydrogenase (NAD+) activity#GO:0004022;catalytic activity#GO:0003824;zinc ion binding#GO:0008270;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;metal ion binding#GO:0046872;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;all-trans-retinol dehydrogenase (NAD+) activity#GO:0004745;cation binding#GO:0043169;binding#GO:0005488;small molecule binding#GO:0036094;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;ion binding#GO:0043167;transition metal ion binding#GO:0046914 catabolic process#GO:0009056;response to toxic substance#GO:0009636;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;isoprenoid metabolic process#GO:0006720;retinol metabolic process#GO:0042572;terpenoid metabolic process#GO:0006721;hormone metabolic process#GO:0042445;biological regulation#GO:0065007;aldehyde catabolic process#GO:0046185;retinoid metabolic process#GO:0001523;diterpenoid metabolic process#GO:0016101;lipid metabolic process#GO:0006629;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;small molecule catabolic process#GO:0044282;cellular detoxification of aldehyde#GO:0110095;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;regulation of hormone levels#GO:0010817;regulation of biological quality#GO:0065008;oxoacid metabolic process#GO:0043436;cellular response to chemical stimulus#GO:0070887;olefinic compound metabolic process#GO:0120254;response to oxygen-containing compound#GO:1901700;cellular detoxification#GO:1990748;response to chemical#GO:0042221;detoxification#GO:0098754;cellular response to toxic substance#GO:0097237;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987;aldehyde metabolic process#GO:0006081;metabolic process#GO:0008152;alcohol metabolic process#GO:0006066 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 dehydrogenase#PC00092 HUMAN|HGNC=25282|UniProtKB=Q96TA1 Q96TA1 NIBAN2 PTHR14392:SF2 NIBAN FAMILY MEMBER PROTEIN NIBAN 2 HUMAN|HGNC=29140|UniProtKB=Q9Y6X3 Q9Y6X3 MAU2 PTHR21394:SF0 MAU2 CHROMATID COHESION FACTOR HOMOLOG MAU2 CHROMATID COHESION FACTOR HOMOLOG catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;catalytic activity, acting on DNA#GO:0140097 cellular process#GO:0009987;cell cycle process#GO:0022402;organelle organization#GO:0006996;cell cycle#GO:0007049;cellular component organization#GO:0016043;mitotic sister chromatid cohesion#GO:0007064;chromosome organization#GO:0051276;cellular component organization or biogenesis#GO:0071840;sister chromatid cohesion#GO:0007062 chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513 HUMAN|HGNC=2858|UniProtKB=Q16854 Q16854 DGUOK PTHR10513:SF8 DEOXYNUCLEOSIDE KINASE DEOXYGUANOSINE KINASE, MITOCHONDRIAL deoxynucleoside kinase activity#GO:0019136;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;nucleobase-containing compound kinase activity#GO:0019205;transferase activity#GO:0016740;catalytic activity#GO:0003824 mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 nucleotide kinase#PC00172;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=8032|UniProtKB=Q16620 Q16620 NTRK2 PTHR24416:SF136 TYROSINE-PROTEIN KINASE RECEPTOR BDNF_NT-3 GROWTH FACTORS RECEPTOR catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;transmembrane receptor protein kinase activity#GO:0019199;transmembrane receptor protein tyrosine kinase activity#GO:0004714;molecular transducer activity#GO:0060089;transferase activity#GO:0016740;kinase activity#GO:0016301;signaling receptor activity#GO:0038023;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888;phosphotransferase activity, alcohol group as acceptor#GO:0016773;growth factor binding#GO:0019838;protein binding#GO:0005515;protein kinase activity#GO:0004672 biological regulation#GO:0065007;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;signal transduction#GO:0007165;cellular process#GO:0009987;neurogenesis#GO:0022008;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;cellular response to nerve growth factor stimulus#GO:1990090;developmental process#GO:0032502;neuron differentiation#GO:0030182;cell surface receptor signaling pathway#GO:0007166;signaling#GO:0023052;cell differentiation#GO:0030154;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;response to growth factor#GO:0070848;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to endogenous stimulus#GO:0009719;cellular response to growth factor stimulus#GO:0071363;system development#GO:0048731;cell communication#GO:0007154;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108 axon#GO:0030424;dendritic tree#GO:0097447;postsynaptic density#GO:0014069;dendrite#GO:0030425;dendritic spine#GO:0043197;postsynapse#GO:0098794;neuron projection terminus#GO:0044306;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;distal axon#GO:0150034;neuron spine#GO:0044309;organelle#GO:0043226;asymmetric synapse#GO:0032279;synapse#GO:0045202;cellular anatomical structure#GO:0110165;signaling receptor complex#GO:0043235;axon terminus#GO:0043679;cell junction#GO:0030054;presynapse#GO:0098793;neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;postsynaptic specialization#GO:0099572;protein-containing complex#GO:0032991;neuron to neuron synapse#GO:0098984 transmembrane signal receptor#PC00197 HUMAN|HGNC=48813|UniProtKB=B2RXH8 B2RXH8 HNRNPCL2 PTHR13968:SF17 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN C-LIKE 1-RELATED nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031 HUMAN|HGNC=24860|UniProtKB=Q5MY95 Q5MY95 ENTPD8 PTHR11782:SF31 ADENOSINE/GUANOSINE DIPHOSPHATASE ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 8 pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;nucleoside diphosphate phosphatase activity#GO:0017110;ribonucleoside triphosphate phosphatase activity#GO:0017111 small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;nucleoside phosphate catabolic process#GO:1901292;nucleobase-containing compound metabolic process#GO:0006139;nucleoside phosphate metabolic process#GO:0006753;organophosphate metabolic process#GO:0019637;nucleobase-containing compound catabolic process#GO:0034655;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;nucleoside diphosphate catabolic process#GO:0009134;cellular process#GO:0009987;organophosphate catabolic process#GO:0046434;nucleobase-containing small molecule metabolic process#GO:0055086;nucleoside diphosphate metabolic process#GO:0009132;metabolic process#GO:0008152 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 phosphatase#PC00181;nucleotide phosphatase#PC00173;hydrolase#PC00121 HUMAN|HGNC=37246|UniProtKB=C9JN71 C9JN71 ZNF878 PTHR24379:SF109 KRAB AND ZINC FINGER DOMAIN-CONTAINING ZINC FINGER PROTEIN 878 double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HUMAN|HGNC=21295|UniProtKB=Q8TE68 Q8TE68 EPS8L1 PTHR12287:SF19 EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8-RELATED PROTEIN EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE 8-LIKE PROTEIN 1 protein binding#GO:0005515;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779 regulation of cell projection assembly#GO:0060491;intracellular signal transduction#GO:0035556;Rho protein signal transduction#GO:0007266;cell communication#GO:0007154;positive regulation of cell projection organization#GO:0031346;regulation of signaling#GO:0023051;positive regulation of cellular component organization#GO:0051130;regulation of intracellular signal transduction#GO:1902531;regulation of cellular component biogenesis#GO:0044087;regulation of cell communication#GO:0010646;signaling#GO:0023052;regulation of Rho protein signal transduction#GO:0035023;regulation of cellular process#GO:0050794;regulation of plasma membrane bounded cell projection assembly#GO:0120032;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of small GTPase mediated signal transduction#GO:0051056;regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of response to stimulus#GO:0048583;regulation of cell projection organization#GO:0031344;intracellular signaling cassette#GO:0141124;regulation of signal transduction#GO:0009966;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;positive regulation of cellular component biogenesis#GO:0044089;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522 cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;cell projection#GO:0042995;membrane#GO:0016020;cell leading edge#GO:0031252;cell periphery#GO:0071944;ruffle#GO:0001726;cell projection membrane#GO:0031253;ruffle membrane#GO:0032587;leading edge membrane#GO:0031256 scaffold/adaptor protein#PC00226 HUMAN|HGNC=7582|UniProtKB=P05976 P05976 MYL1 PTHR23048:SF3 MYOSIN LIGHT CHAIN 1, 3 MYOSIN LIGHT CHAIN 1_3, SKELETAL MUSCLE ISOFORM structural molecule activity#GO:0005198;isomerase activity#GO:0016853;cytoskeletal motor activity#GO:0003774;macromolecular conformation isomerase activity#GO:0120543;microfilament motor activity#GO:0000146;catalytic activity#GO:0003824;ATP-dependent activity#GO:0140657;polypeptide conformation or assembly isomerase activity#GO:0120544 intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;supramolecular complex#GO:0099080;organelle#GO:0043226;contractile muscle fiber#GO:0043292;myosin complex#GO:0016459;actin cytoskeleton#GO:0015629 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=33891|UniProtKB=A6NNM3 A6NNM3 RIMBP3B PTHR14234:SF21 RIM BINDING PROTEIN-RELATED RIMS-BINDING PROTEIN 3A-RELATED protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488 cell differentiation#GO:0030154;gamete generation#GO:0007276;cellular process involved in reproduction in multicellular organism#GO:0022412;cell development#GO:0048468;reproductive process#GO:0022414;fertilization#GO:0009566;developmental process involved in reproduction#GO:0003006;germ cell development#GO:0007281;anatomical structure development#GO:0048856;multicellular organismal reproductive process#GO:0048609;spermatid differentiation#GO:0048515;sexual reproduction#GO:0019953;spermatid development#GO:0007286;male gamete generation#GO:0048232;cellular process#GO:0009987;cellular developmental process#GO:0048869;spermatogenesis#GO:0007283;developmental process#GO:0032502 intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;microtubule cytoskeleton#GO:0015630;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 scaffold/adaptor protein#PC00226 HUMAN|HGNC=24308|UniProtKB=Q96KA5 Q96KA5 CLPTM1L PTHR21347:SF0 CLEFT LIP AND PALATE ASSOCIATED TRANSMEMBRANE PROTEIN-RELATED LIPID SCRAMBLASE CLPTM1L membrane#GO:0016020;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 HUMAN|HGNC=27200|UniProtKB=Q1W4C9 Q1W4C9 SPINK13 PTHR21312:SF36 SERINE PROTEASE INHIBITOR SERINE PROTEASE INHIBITOR KAZAL-TYPE 13 protease inhibitor#PC00191;protein-binding activity modulator#PC00095 HUMAN|HGNC=25620|UniProtKB=Q8WWA1 Q8WWA1 TMEM40 PTHR16108:SF2 FAMILY NOT NAMED TRANSMEMBRANE PROTEIN 40 HUMAN|HGNC=4800|UniProtKB=Q99714 Q99714 HSD17B10 PTHR43658:SF17 SHORT-CHAIN DEHYDROGENASE/REDUCTASE 3-HYDROXYACYL-COA DEHYDROGENASE TYPE-2 oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824 oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;lipid metabolic process#GO:0006629;estrogen metabolic process#GO:0008210;regulation of biological quality#GO:0065008;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;regulation of hormone levels#GO:0010817;cellular process#GO:0009987;hormone metabolic process#GO:0042445;small molecule metabolic process#GO:0044281;biological regulation#GO:0065007;steroid metabolic process#GO:0008202 mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=3064|UniProtKB=P28562 P28562 DUSP1 PTHR10159:SF309 DUAL SPECIFICITY PROTEIN PHOSPHATASE DUAL SPECIFICITY PROTEIN PHOSPHATASE 1 catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;protein tyrosine/serine/threonine phosphatase activity#GO:0008138;phosphoprotein phosphatase activity#GO:0004721;protein tyrosine phosphatase activity#GO:0004725;hydrolase activity#GO:0016787 biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of response to stimulus#GO:0048585;multicellular organismal process#GO:0032501;tissue development#GO:0009888;regulation of response to stimulus#GO:0048583;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;cellular response to stimulus#GO:0051716;negative regulation of MAPK cascade#GO:0043409;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;cell communication#GO:0007154;cellular process#GO:0009987;signal transduction#GO:0007165;embryo development#GO:0009790;endoderm formation#GO:0001706;negative regulation of signal transduction#GO:0009968;regulation of MAPK cascade#GO:0043408;anatomical structure formation involved in morphogenesis#GO:0048646;endoderm development#GO:0007492;embryonic morphogenesis#GO:0048598;multicellular organism development#GO:0007275;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;gastrulation#GO:0007369;negative regulation of biological process#GO:0048519;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of signaling#GO:0023051;formation of primary germ layer#GO:0001704;regulation of intracellular signal transduction#GO:1902531;animal gross anatomical part developmental process#GO:0160108;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 protein phosphatase#PC00195 Oxidative stress response#P00046>MKP5#P01131;Gonadotropin-releasing hormone receptor pathway#P06664>DUSP1#P06823;p38 MAPK pathway#P05918>MKP1#P05922 HUMAN|HGNC=6393|UniProtKB=Q99661 Q99661 KIF2C PTHR24115:SF454 KINESIN-RELATED KINESIN-LIKE PROTEIN KIF2C ATP-dependent activity#GO:0140657;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;hydrolase activity, acting on acid anhydrides#GO:0016817;cytoskeletal motor activity#GO:0003774;microtubule binding#GO:0008017;polypeptide conformation or assembly isomerase activity#GO:0120544;ATP hydrolysis activity#GO:0016887;microtubule motor activity#GO:0003777;hydrolase activity#GO:0016787;macromolecular conformation isomerase activity#GO:0120543;tubulin binding#GO:0015631;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;isomerase activity#GO:0016853 cilium organization#GO:0044782;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cell projection organization#GO:0030030;microtubule-based movement#GO:0007018;cell projection assembly#GO:0030031;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;cilium assembly#GO:0060271 centrosome#GO:0005813;microtubule organizing center#GO:0005815;spindle#GO:0005819;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;intracellular organelle#GO:0043229;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;organelle#GO:0043226;cellular anatomical structure#GO:0110165 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=18122|UniProtKB=Q9H6I2 Q9H6I2 SOX17 PTHR10270:SF216 SOX TRANSCRIPTION FACTOR TRANSCRIPTION FACTOR SOX-17 sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;sequence-specific DNA binding#GO:0043565;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription activator activity#GO:0001216;transcription regulator activity#GO:0140110;transcription regulatory region nucleic acid binding#GO:0001067 regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;regulation of cell communication#GO:0010646;anatomical structure development#GO:0048856;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of response to stimulus#GO:0048585;multicellular organismal process#GO:0032501;positive regulation of DNA-templated transcription#GO:0045893;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;regulation of biosynthetic process#GO:0009889;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of transcription by RNA polymerase II#GO:0006357;regulation of Wnt signaling pathway#GO:0030111;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;positive regulation of macromolecule biosynthetic process#GO:0010557;angiogenesis#GO:0001525;negative regulation of cell communication#GO:0010648;negative regulation of signaling#GO:0023057;animal gross anatomical part developmental process#GO:0160108;formation of primary germ layer#GO:0001704;regulation of signaling#GO:0023051;positive regulation of macromolecule metabolic process#GO:0010604;vasculogenesis#GO:0001570;endoderm formation#GO:0001706;embryo development#GO:0009790;negative regulation of signal transduction#GO:0009968;regulation of canonical Wnt signaling pathway#GO:0060828;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;multicellular organism development#GO:0007275;vasculature development#GO:0001944;anatomical structure formation involved in morphogenesis#GO:0048646;blood vessel development#GO:0001568;tube morphogenesis#GO:0035239;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;system development#GO:0048731;tissue development#GO:0009888;negative regulation of Wnt signaling pathway#GO:0030178;regulation of RNA biosynthetic process#GO:2001141;regulation of signal transduction#GO:0009966;positive regulation of RNA biosynthetic process#GO:1902680;tube development#GO:0035295;regulation of macromolecule biosynthetic process#GO:0010556;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;developmental process#GO:0032502;circulatory system development#GO:0072359;cell differentiation#GO:0030154;gastrulation#GO:0007369;blood vessel morphogenesis#GO:0048514;positive regulation of metabolic process#GO:0009893;negative regulation of canonical Wnt signaling pathway#GO:0090090;heart development#GO:0007507;embryonic morphogenesis#GO:0048598;animal organ development#GO:0048513;endoderm development#GO:0007492;positive regulation of transcription by RNA polymerase II#GO:0045944 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264;HMG box transcription factor#PC00024 HUMAN|HGNC=32249|UniProtKB=Q6UY27 Q6UY27 PATE2 PTHR47884:SF1 PROSTATE AND TESTIS EXPRESSED PROTEIN 2 PROSTATE AND TESTIS EXPRESSED PROTEIN 2 HUMAN|HGNC=33784|UniProtKB=Q6ZNB7 Q6ZNB7 AGMO PTHR21624:SF1 STEROL DESATURASE-RELATED PROTEIN ALKYLGLYCEROL MONOOXYGENASE oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;monooxygenase activity#GO:0004497;catalytic activity#GO:0003824 cellular process#GO:0009987;lipid metabolic process#GO:0006629;primary metabolic process#GO:0044238;metabolic process#GO:0008152 endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=11951|UniProtKB=P09430 P09430 TNP1 PTHR17486:SF0 SPERMATID NUCLEAR TRANSITION PROTEIN 1 SPERMATID NUCLEAR TRANSITION PROTEIN 1 nucleic acid binding#GO:0003676;binding#GO:0005488;DNA binding#GO:0003677 cellular process involved in reproduction in multicellular organism#GO:0022412;cell development#GO:0048468;reproductive process#GO:0022414;chromatin remodeling#GO:0006338;gamete generation#GO:0007276;cell differentiation#GO:0030154;germ cell development#GO:0007281;developmental process involved in reproduction#GO:0003006;cellular component organization#GO:0016043;multicellular organismal reproductive process#GO:0048609;anatomical structure development#GO:0048856;spermatid development#GO:0007286;sexual reproduction#GO:0019953;spermatid differentiation#GO:0048515;chromatin organization#GO:0006325;male gamete generation#GO:0048232;cellular process#GO:0009987;organelle organization#GO:0006996;cellular developmental process#GO:0048869;nucleus organization#GO:0006997;cellular component organization or biogenesis#GO:0071840;spermatogenesis#GO:0007283;developmental process#GO:0032502 membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;protein-DNA complex#GO:0032993;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;nucleosome#GO:0000786;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;nucleus#GO:0005634;chromatin#GO:0000785 HUMAN|HGNC=19253|UniProtKB=O75170 O75170 PPP6R2 PTHR12634:SF15 SIT4 YEAST -ASSOCIATING PROTEIN-RELATED SERINE_THREONINE-PROTEIN PHOSPHATASE 6 REGULATORY SUBUNIT 2 enzyme regulator activity#GO:0030234;phosphatase regulator activity#GO:0019208;protein phosphatase regulator activity#GO:0019888;molecular function regulator activity#GO:0098772 regulation of biological process#GO:0050789;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;cytosol#GO:0005829 phosphatase modulator#PC00184 HUMAN|HGNC=18179|UniProtKB=Q96AX1 Q96AX1 VPS33A PTHR11679:SF85 VESICLE PROTEIN SORTING-ASSOCIATED VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 33A intracellular transport#GO:0046907;transport#GO:0006810;intracellular protein transport#GO:0006886;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;protein transport#GO:0015031;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192 protein-containing complex#GO:0032991;endomembrane system#GO:0012505;vacuole#GO:0005773;cytoplasm#GO:0005737;lytic vacuole#GO:0000323;vesicle tethering complex#GO:0099023;intracellular vesicle#GO:0097708;vesicle#GO:0031982;lysosome#GO:0005764;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622 membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=17206|UniProtKB=Q9NWH2 Q9NWH2 TMEM242 PTHR13141:SF4 TRANSMEMBRANE PROTEIN 242 TRANSMEMBRANE PROTEIN 242 HUMAN|HGNC=24771|UniProtKB=Q6ZUJ4 Q6ZUJ4 C3orf62 PTHR36680:SF1 HYPOTHETICAL LOC498675 CHROMOSOME 3 OPEN READING FRAME 62 HUMAN|HGNC=26714|UniProtKB=Q8TED9 Q8TED9 AFAP1L1 PTHR14338:SF1 ACTIN FILAMENT-ASSOCIATED PROTEIN 1 FAMILY MEMBER ACTIN FILAMENT-ASSOCIATED PROTEIN 1-LIKE 1 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 HUMAN|HGNC=14729|UniProtKB=O95047 O95047 OR2A4 PTHR26451:SF971 G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN OLFACTORY RECEPTOR 2A4-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488 sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception#GO:0007600;nervous system process#GO:0050877;system process#GO:0003008;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;detection of chemical stimulus#GO:0009593;response to chemical#GO:0042221;response to stimulus#GO:0050896;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608 cellular anatomical structure#GO:0110165;membrane#GO:0016020 G-protein coupled receptor#PC00021 HUMAN|HGNC=10569|UniProtKB=P29508 P29508 SERPINB3 PTHR11461:SF320 SERINE PROTEASE INHIBITOR, SERPIN SERPIN B3 molecular function inhibitor activity#GO:0140678;serine-type endopeptidase inhibitor activity#GO:0004867;enzyme regulator activity#GO:0030234;peptidase regulator activity#GO:0061134;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866;enzyme inhibitor activity#GO:0004857 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;extracellular region#GO:0005576 protease inhibitor#PC00191 HUMAN|HGNC=12105|UniProtKB=A0A0B4J245 A0A0B4J245 TRAV12-1 PTHR19343:SF18 T CELL RECEPTOR ALPHA VARIABLE 1-2 T CELL RECEPTOR ALPHA VARIABLE 12-1 peptide binding#GO:0042277;antigen binding#GO:0003823;binding#GO:0005488 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|Ensembl=ENSG00000285304.1|UniProtKB=Q6ZT62 Q6ZT62 BARGIN PTHR14130:SF12 3BP-1 RELATED RHOGAP BARGIN-RELATED molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;enzyme activator activity#GO:0008047 negative regulation of response to stimulus#GO:0048585;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of actin cytoskeleton organization#GO:0032956;negative regulation of signal transduction#GO:0009968;negative regulation of cellular process#GO:0048523;regulation of actin filament-based process#GO:0032970;regulation of response to stimulus#GO:0048583;regulation of small GTPase mediated signal transduction#GO:0051056;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;cytosol#GO:0005829 GTPase-activating protein#PC00257 HUMAN|HGNC=29211|UniProtKB=A4D1T9 A4D1T9 PRSS37 PTHR24271:SF61 KALLIKREIN-RELATED INACTIVE SERINE PROTEASE 37-RELATED catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171 metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;regulation of reproductive process#GO:2000241;gene expression#GO:0010467;protein maturation#GO:0051604;biological regulation#GO:0065007;biosynthetic process#GO:0009058 membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;acrosomal vesicle#GO:0001669;intracellular organelle#GO:0043229;extracellular region#GO:0005576;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular vesicle#GO:0097708;secretory vesicle#GO:0099503;vesicle#GO:0031982 serine protease#PC00203 HUMAN|HGNC=15889|UniProtKB=Q9BQL6 Q9BQL6 FERMT1 PTHR16160:SF12 FERMITIN 2-RELATED FERMITIN FAMILY HOMOLOG 1 protein binding#GO:0005515;protein-containing complex binding#GO:0044877;integrin binding#GO:0005178;signaling receptor binding#GO:0005102;binding#GO:0005488;cell adhesion molecule binding#GO:0050839 cell-substrate adhesion#GO:0031589;cellular process#GO:0009987;cell-matrix adhesion#GO:0007160;cell adhesion#GO:0007155 cell-substrate junction#GO:0030055;focal adhesion#GO:0005925;anchoring junction#GO:0070161;cell junction#GO:0030054;cellular anatomical structure#GO:0110165 HUMAN|HGNC=15450|UniProtKB=O43493 O43493 TGOLN2 PTHR23211:SF0 TRANS-GOLGI NETWORK INTEGRAL MEMBRANE PROTEIN TGN38 TRANS-GOLGI NETWORK INTEGRAL MEMBRANE PROTEIN 2 membrane traffic protein#PC00150 HUMAN|HGNC=11108|UniProtKB=Q6STE5 Q6STE5 SMARCD3 PTHR13844:SF5 SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D MEMBER 3 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;SWI/SNF superfamily-type complex#GO:0070603;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;SWI/SNF complex#GO:0016514;ATPase complex#GO:1904949;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;chromatin#GO:0000785;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228 chromatin/chromatin-binding, or -regulatory protein#PC00077 Wnt signaling pathway#P00057>SWI/SNF#P01435 HUMAN|HGNC=2495|UniProtKB=P56545 P56545 CTBP2 PTHR46029:SF3 C-TERMINAL-BINDING PROTEIN C-TERMINAL-BINDING PROTEIN 2 protein binding#GO:0005515;DNA-binding transcription factor binding#GO:0140297;binding#GO:0005488;transcription regulator activity#GO:0140110;transcription coactivator activity#GO:0003713;transcription coregulator activity#GO:0003712;transcription factor binding#GO:0008134;transcription corepressor activity#GO:0003714 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 transcription cofactor#PC00217 Wnt signaling pathway#P00057>C-terminal Binding Protein#P01439 HUMAN|HGNC=24079|UniProtKB=A6QL64 A6QL64 ANKRD36 PTHR24147:SF50 ANKYRIN REPEAT DOMAIN 36-RELATED ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 36A-RELATED HUMAN|HGNC=21248|UniProtKB=A2RRH5 A2RRH5 WDR27 PTHR44525:SF1 WD REPEAT-CONTAINING PROTEIN 27 WD REPEAT-CONTAINING PROTEIN 27 HUMAN|HGNC=26582|UniProtKB=Q8N2C7 Q8N2C7 UNC80 PTHR31781:SF1 UNC80 PROTEIN UNC-80 HOMOLOG monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic cation channel activity#GO:0005261 metal ion transport#GO:0030001;homeostatic process#GO:0042592;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;sodium ion transport#GO:0006814;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;monoatomic cation transmembrane transport#GO:0098655;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;regulation of multicellular organismal process#GO:0051239;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;transport#GO:0006810;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;regulation of system process#GO:0044057 transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;sodium channel complex#GO:0034706;axon#GO:0030424;cation channel complex#GO:0034703;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;membrane#GO:0016020;membrane protein complex#GO:0098796;neuron projection#GO:0043005 HUMAN|HGNC=21181|UniProtKB=Q6EEV6 Q6EEV6 SUMO4 PTHR10562:SF131 SMALL UBIQUITIN-RELATED MODIFIER SMALL UBIQUITIN-RELATED MODIFIER 2-RELATED protein binding#GO:0005515;ubiquitin-like protein ligase binding#GO:0044389;binding#GO:0005488;enzyme binding#GO:0019899 post-translational protein modification#GO:0043687;cellular process#GO:0009987;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein sumoylation#GO:0016925;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 p53 pathway#P00059>Sumo-1 ligase#P04635 HUMAN|HGNC=4464|UniProtKB=P49683 P49683 PRLHR PTHR24235:SF11 NEUROPEPTIDE Y RECEPTOR PROLACTIN-RELEASING PEPTIDE RECEPTOR neuropeptide receptor activity#GO:0008188;G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;signaling receptor activity#GO:0038023 cell communication#GO:0007154;feeding behavior#GO:0007631;G protein-coupled receptor signaling pathway#GO:0007186;regulation of cellular process#GO:0050794;multicellular organismal process#GO:0032501;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;neuropeptide signaling pathway#GO:0007218;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;cell projection#GO:0042995;membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=4849|UniProtKB=O43614 O43614 HCRTR2 PTHR24241:SF75 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR OREXIN RECEPTOR TYPE 2 signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528 G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887;cell communication#GO:0007154;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to endogenous stimulus#GO:0009719;neuropeptide signaling pathway#GO:0007218;signaling#GO:0023052;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;cellular response to hormone stimulus#GO:0032870;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;cellular process#GO:0009987;response to hormone#GO:0009725;biological regulation#GO:0065007;response to chemical#GO:0042221 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=32390|UniProtKB=Q6GV28 Q6GV28 TMEM225 PTHR36477:SF1 TRANSMEMBRANE PROTEIN 225 TRANSMEMBRANE PROTEIN 225 HUMAN|HGNC=10743|UniProtKB=Q02383 Q02383 SEMG2 PTHR10547:SF6 SEMENOGELIN/SEMINAL VESICLE SECRETORY PROTEIN SEMENOGELIN-2 anatomical structure development#GO:0048856;multicellular organismal reproductive process#GO:0048609;spermatid differentiation#GO:0048515;spermatid development#GO:0007286;sexual reproduction#GO:0019953;gamete generation#GO:0007276;cell differentiation#GO:0030154;reproductive process#GO:0022414;cellular process involved in reproduction in multicellular organism#GO:0022412;cell development#GO:0048468;developmental process involved in reproduction#GO:0003006;germ cell development#GO:0007281;anatomical structure maturation#GO:0071695;cellular developmental process#GO:0048869;cell maturation#GO:0048469;developmental process#GO:0032502;spermatogenesis#GO:0007283;male gamete generation#GO:0048232;developmental maturation#GO:0021700;sperm capacitation#GO:0048240;cellular process#GO:0009987 intracellular vesicle#GO:0097708;secretory vesicle#GO:0099503;vesicle#GO:0031982;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;acrosomal vesicle#GO:0001669;intracellular organelle#GO:0043229;extracellular region#GO:0005576;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=29254|UniProtKB=Q9P2J8 Q9P2J8 ZNF624 PTHR24377:SF823 IP01015P-RELATED ZINC FINGER PROTEIN 624 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=4636|UniProtKB=Q03013 Q03013 GSTM4 PTHR11571:SF137 GLUTATHIONE S-TRANSFERASE GLUTATHIONE S-TRANSFERASE MU 4 glutathione transferase activity#GO:0004364;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765 metabolic process#GO:0008152;sulfur compound metabolic process#GO:0006790;modified amino acid metabolic process#GO:0006575;glutathione metabolic process#GO:0006749;cellular process#GO:0009987 transferase#PC00220 HUMAN|HGNC=18429|UniProtKB=Q14914 Q14914 PTGR1 PTHR43205:SF33 PROSTAGLANDIN REDUCTASE PROSTAGLANDIN REDUCTASE 1 catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627 unsaturated fatty acid metabolic process#GO:0033559;prostaglandin metabolic process#GO:0006693;lipid metabolic process#GO:0006629;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;cellular process#GO:0009987;monocarboxylic acid metabolic process#GO:0032787;long-chain fatty acid metabolic process#GO:0001676;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;small molecule metabolic process#GO:0044281;icosanoid metabolic process#GO:0006690 reductase#PC00198 HUMAN|HGNC=4580|UniProtKB=Q13002 Q13002 GRIK2 PTHR18966:SF38 IONOTROPIC GLUTAMATE RECEPTOR GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2 signaling receptor activity#GO:0038023;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;transporter activity#GO:0005215;neurotransmitter receptor activity#GO:0030594;amino acid transmembrane transporter activity#GO:0015171;monoatomic cation transmembrane transporter activity#GO:0008324;gated channel activity#GO:0022836;transmembrane signaling receptor activity#GO:0004888;sodium ion transmembrane transporter activity#GO:0015081;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;dicarboxylic acid transmembrane transporter activity#GO:0005310;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;sodium channel activity#GO:0005272;ligand-gated monoatomic cation channel activity#GO:0099094;glutamate receptor activity#GO:0008066;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;channel activity#GO:0015267;molecular transducer activity#GO:0060089;potassium ion transmembrane transporter activity#GO:0015079;carboxylic acid transmembrane transporter activity#GO:0046943;potassium channel activity#GO:0005267;ligand-gated monoatomic ion channel activity#GO:0015276 modulation of chemical synaptic transmission#GO:0050804;signaling#GO:0023052;regulation of cell communication#GO:0010646;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;cell communication#GO:0007154;regulation of signaling#GO:0023051;trans-synaptic signaling#GO:0099537;synaptic transmission, glutamatergic#GO:0035249;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;regulation of trans-synaptic signaling#GO:0099177;cellular process#GO:0009987;synaptic signaling#GO:0099536 postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;neuron to neuron synapse#GO:0098984;plasma membrane#GO:0005886;presynaptic membrane#GO:0042734;membrane#GO:0016020;presynapse#GO:0098793;cell periphery#GO:0071944;cell junction#GO:0030054;transporter complex#GO:1990351;cation channel complex#GO:0034703;synaptic membrane#GO:0097060;signaling receptor complex#GO:0043235;organelle#GO:0043226;asymmetric synapse#GO:0032279;cellular anatomical structure#GO:0110165;synapse#GO:0045202;membrane protein complex#GO:0098796;postsynapse#GO:0098794;plasma membrane protein complex#GO:0098797;transmembrane transporter complex#GO:1902495;sodium channel complex#GO:0034706;postsynaptic density membrane#GO:0098839;postsynaptic specialization membrane#GO:0099634;postsynaptic membrane#GO:0045211;postsynaptic density#GO:0014069 transmembrane signal receptor#PC00197 Ionotropic glutamate receptor pathway#P00037>KA2#P01003;Ionotropic glutamate receptor pathway#P00037>KA#P01026;Huntington disease#P00029>Kainate receptor#P00796;Metabotropic glutamate receptor group III pathway#P00039>A/K#P01046;Ionotropic glutamate receptor pathway#P00037>A/K#P01025 HUMAN|HGNC=8573|UniProtKB=P09466 P09466 PAEP PTHR11430:SF117 LIPOCALIN GLYCODELIN cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 transfer/carrier protein#PC00219 HUMAN|HGNC=24282|UniProtKB=Q9Y388 Q9Y388 RBMX2 PTHR45880:SF4 RNA-BINDING MOTIF PROTEIN, X-LINKED 2 RNA-BINDING MOTIF PROTEIN, X-LINKED 2 RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;mRNA splicing, via spliceosome#GO:0000398;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375 small nuclear ribonucleoprotein complex#GO:0030532;nucleus#GO:0005634;protein-containing complex#GO:0032991;U2 snRNP#GO:0005686;Sm-like protein family complex#GO:0120114;catalytic step 2 spliceosome#GO:0071013;nuclear protein-containing complex#GO:0140513;spliceosomal complex#GO:0005681;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;ribonucleoprotein complex#GO:1990904;precatalytic spliceosome#GO:0071011;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;spliceosomal snRNP complex#GO:0097525;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=28985|UniProtKB=Q92604 Q92604 LPGAT1 PTHR10983:SF2 1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED ACYL-COA:LYSOPHOSPHATIDYLGLYCEROL ACYLTRANSFERASE 1 acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740 metabolic process#GO:0008152;lipid metabolic process#GO:0006629;phosphatidylinositol metabolic process#GO:0046488;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;glycerolipid metabolic process#GO:0046486;glycerophospholipid metabolic process#GO:0006650;phospholipid metabolic process#GO:0006644 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 transferase#PC00220;acyltransferase#PC00042 HUMAN|HGNC=5331|UniProtKB=Q9HC29 Q9HC29 NOD2 PTHR24106:SF64 NACHT, LRR AND CARD DOMAINS-CONTAINING NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 2 molecular function regulator activity#GO:0098772;molecular function inhibitor activity#GO:0140678;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;pattern recognition receptor activity#GO:0038187 positive regulation of response to external stimulus#GO:0032103;positive regulation of canonical NF-kappaB signal transduction#GO:0043123;immune response-activating signaling pathway#GO:0002757;cellular process#GO:0009987;activation of immune response#GO:0002253;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;positive regulation of immune system process#GO:0002684;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;regulation of response to external stimulus#GO:0032101;response to chemical#GO:0042221;regulation of signaling#GO:0023051;response to oxygen-containing compound#GO:1901700;defense response to bacterium#GO:0042742;regulation of intracellular signal transduction#GO:1902531;immune system process#GO:0002376;positive regulation of signaling#GO:0023056;immune response-regulating signaling pathway#GO:0002764;regulation of biological process#GO:0050789;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of defense response#GO:0031349;regulation of response to stress#GO:0080134;defense response#GO:0006952;pattern recognition receptor signaling pathway#GO:0002221;response to external stimulus#GO:0009605;positive regulation of response to biotic stimulus#GO:0002833;regulation of innate immune response#GO:0045088;positive regulation of innate immune response#GO:0045089;regulation of canonical NF-kappaB signal transduction#GO:0043122;positive regulation of cellular process#GO:0048522;activation of innate immune response#GO:0002218;response to other organism#GO:0051707;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;regulation of defense response#GO:0031347;regulation of immune response#GO:0050776;response to bacterium#GO:0009617;intracellular signal transduction#GO:0035556;response to nitrogen compound#GO:1901698;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;innate immune response-activating signaling pathway#GO:0002758;regulation of response to biotic stimulus#GO:0002831;regulation of cell communication#GO:0010646;response to external biotic stimulus#GO:0043207;regulation of immune system process#GO:0002682;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=11753|UniProtKB=P19484 P19484 TFEB PTHR45776:SF5 MIP04163P TRANSCRIPTION FACTOR EB sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;positive regulation of autophagy#GO:0010508;organelle organization#GO:0006996;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;lysosome organization#GO:0007040;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;positive regulation of catabolic process#GO:0009896;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;lytic vacuole organization#GO:0080171;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of autophagy#GO:0010506;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;positive regulation of metabolic process#GO:0009893;regulation of DNA-templated transcription#GO:0006355;vacuole organization#GO:0007033;regulation of RNA metabolic process#GO:0051252 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264;basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=16016|UniProtKB=Q5KU26 Q5KU26 COLEC12 PTHR24023:SF910 COLLAGEN ALPHA COLLECTIN-12 protein-lipid complex binding#GO:0071814;low-density lipoprotein particle binding#GO:0030169;signaling receptor activity#GO:0038023;structural molecule activity#GO:0005198;binding#GO:0005488;lipoprotein particle binding#GO:0071813;extracellular matrix structural constituent#GO:0005201;pattern recognition receptor activity#GO:0038187;molecular transducer activity#GO:0060089;protein-containing complex binding#GO:0044877 endocytosis#GO:0006897;cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;localization#GO:0051179;extracellular matrix organization#GO:0030198;establishment of localization#GO:0051234;import into cell#GO:0098657;external encapsulating structure organization#GO:0045229;extracellular structure organization#GO:0043062;phagocytosis#GO:0006909;transport#GO:0006810;cell recognition#GO:0008037 extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cellular anatomical structure#GO:0110165 extracellular matrix structural protein#PC00103;extracellular matrix protein#PC00102 HUMAN|HGNC=15178|UniProtKB=Q8NGE8 Q8NGE8 OR4D9 PTHR48002:SF108 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 4D9 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=53854|UniProtKB=A0A1W2PQ09 A0A1W2PQ09 TAF11L11 PTHR13218:SF15 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11-RELATED TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 11 LIKE PROTEIN 2-RELATED macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;transcription initiation at RNA polymerase II promoter#GO:0006367;cellular component biogenesis#GO:0044085;biosynthetic process#GO:0009058;protein-DNA complex assembly#GO:0065004;nucleobase-containing compound metabolic process#GO:0006139;cellular component assembly#GO:0022607;gene expression#GO:0010467;transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;protein-containing complex organization#GO:0043933;protein-DNA complex organization#GO:0071824;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;protein-containing complex assembly#GO:0065003;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;RNA polymerase II preinitiation complex assembly#GO:0051123;DNA-templated transcription initiation#GO:0006352;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070 intracellular protein-containing complex#GO:0140535;transcription regulator complex#GO:0005667;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234;transcription factor TFIID complex#GO:0005669;protein-containing complex#GO:0032991;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;RNA polymerase II transcription regulator complex#GO:0090575;membrane-enclosed lumen#GO:0031974;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;membrane-bounded organelle#GO:0043227;RNA polymerase II, holoenzyme#GO:0016591;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233 general transcription factor#PC00259;RNA metabolism protein#PC00031 Transcription regulation by bZIP transcription factor#P00055>TBP-associated factors#P01385;General transcription regulation#P00023>TBP-associated factors#P00658 HUMAN|HGNC=23323|UniProtKB=Q9H1U9 Q9H1U9 SLC25A51 PTHR46131:SF2 SD08549P MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER SLC25A51-RELATED organophosphate ester transmembrane transporter activity#GO:0015605;nucleobase-containing compound transmembrane transporter activity#GO:0015932;purine nucleotide transmembrane transporter activity#GO:0015216;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 organophosphate ester transport#GO:0015748;nucleobase-containing compound transport#GO:0015931;cellular process#GO:0009987;nitrogen compound transport#GO:0071705;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=31986|UniProtKB=Q3SYB3 Q3SYB3 FOXD4L6 PTHR11829:SF420 FORKHEAD BOX PROTEIN FORKHEAD BOX PROTEIN D4-LIKE 3-RELATED sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677 developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 winged helix/forkhead transcription factor#PC00246;gene-specific transcriptional regulator#PC00264;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=27938|UniProtKB=A6NJV1 A6NJV1 CIMIP2C PTHR34924:SF1 UPF0573 PROTEIN C2ORF70 CILIARY MICROTUBULE INNER PROTEIN 2C HUMAN|HGNC=5619|UniProtKB=A0A0C4DH42 A0A0C4DH42 IGHV3-66 PTHR23266:SF384 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 3-53-RELATED binding#GO:0005488;antigen binding#GO:0003823 immune response#GO:0006955;adaptive immune response#GO:0002250;response to stimulus#GO:0050896;immune effector process#GO:0002252;immune system process#GO:0002376;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=3596|UniProtKB=Q9NYQ8 Q9NYQ8 FAT2 PTHR24026:SF37 FAT ATYPICAL CADHERIN-RELATED PROTOCADHERIN FAT 2 cell-cell adhesion#GO:0098609;cellular process#GO:0009987;cell adhesion#GO:0007155 cell-cell junction#GO:0005911;adherens junction#GO:0005912;anchoring junction#GO:0070161;cell junction#GO:0030054;cellular anatomical structure#GO:0110165 cadherin#PC00057 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HUMAN|HGNC=10473|UniProtKB=Q13761 Q13761 RUNX3 PTHR11950:SF43 RUNT RELATED RUNT-RELATED TRANSCRIPTION FACTOR 3 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of developmental process#GO:0050793;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;ossification#GO:0001503;system development#GO:0048731;cartilage development#GO:0051216;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;hemopoiesis#GO:0030097;regulation of nucleobase-containing compound metabolic process#GO:0019219;chondrocyte differentiation#GO:0002062;tissue development#GO:0009888;multicellular organismal process#GO:0032501;developmental process#GO:0032502;regulation of cell differentiation#GO:0045595;regulation of gene expression#GO:0010468;connective tissue development#GO:0061448;neurogenesis#GO:0022008;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of biological process#GO:0050789;cell development#GO:0048468;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;skeletal system development#GO:0001501;cellular process#GO:0009987;nervous system development#GO:0007399;neuron differentiation#GO:0030182;multicellular organism development#GO:0007275;animal organ development#GO:0048513 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 DNA-binding transcription factor#PC00218;Runt transcription factor#PC00254 HUMAN|HGNC=16091|UniProtKB=Q9NUB1 Q9NUB1 ACSS1 PTHR24095:SF110 ACETYL-COENZYME A SYNTHETASE ACETYL-COENZYME A SYNTHETASE 2-LIKE, MITOCHONDRIAL ligase activity, forming carbon-sulfur bonds#GO:0016877;catalytic activity#GO:0003824;ligase activity#GO:0016874 purine-containing compound metabolic process#GO:0072521;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;acetyl-CoA metabolic process#GO:0006084;purine-containing compound biosynthetic process#GO:0072522;organophosphate biosynthetic process#GO:0090407;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;sulfur compound metabolic process#GO:0006790;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleobase-containing small molecule metabolic process#GO:0055086;acyl-CoA metabolic process#GO:0006637;nucleoside phosphate biosynthetic process#GO:1901293 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 ligase#PC00142 Acetate utilization#P02722>Acetyl-CoA synthetase#P02803 HUMAN|HGNC=8656|UniProtKB=Q9BZA7 Q9BZA7 PCDH11X PTHR24028:SF254 CADHERIN-87A PROTOCADHERIN-11 X-LINKED-RELATED cellular process#GO:0009987;cell adhesion#GO:0007155 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 cadherin#PC00057;cell adhesion molecule#PC00069 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HUMAN|HGNC=27011|UniProtKB=A6NDS4 A6NDS4 TBC1D3B PTHR22957:SF537 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN TBC1 DOMAIN FAMILY MEMBER 3B molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;enzyme activator activity#GO:0008047 GTPase-activating protein#PC00257;protein-binding activity modulator#PC00095;G-protein modulator#PC00022 HUMAN|HGNC=26391|UniProtKB=Q6ZP80 Q6ZP80 TMEM182 PTHR32012:SF0 TRANSMEMBRANE PROTEIN 182-RELATED TRANSMEMBRANE PROTEIN 182 HUMAN|HGNC=12776|UniProtKB=O96014 O96014 WNT11 PTHR12027:SF7 WNT RELATED PROTEIN WNT-11 protein binding#GO:0005515;molecular function activator activity#GO:0140677;cytokine activity#GO:0005125;binding#GO:0005488;signaling receptor binding#GO:0005102;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;frizzled binding#GO:0005109;G protein-coupled receptor binding#GO:0001664 cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signaling#GO:0023052;regulation of cellular process#GO:0050794;Wnt signaling pathway#GO:0016055;cell differentiation#GO:0030154;response to stimulus#GO:0050896;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;cell fate commitment#GO:0045165;anatomical structure development#GO:0048856;canonical Wnt signaling pathway#GO:0060070;cell communication#GO:0007154;cellular process#GO:0009987;signal transduction#GO:0007165;nervous system development#GO:0007399;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;cell surface receptor signaling pathway#GO:0007166;developmental process#GO:0032502;neuron differentiation#GO:0030182;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 Cadherin signaling pathway#P00012>Wnt#P00474;Wnt signaling pathway#P00057>Wnt#P01444;Alzheimer disease-presenilin pathway#P00004>Wnt#P00142 HUMAN|HGNC=28368|UniProtKB=Q9BUU2 Q9BUU2 METTL22 PTHR23108:SF0 METHYLTRANSFERASE-RELATED METHYLTRANSFERASE-LIKE PROTEIN 22 methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein methyltransferase activity#GO:0008276;catalytic activity, acting on a protein#GO:0140096 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 methyltransferase#PC00155 HUMAN|HGNC=15513|UniProtKB=Q9H7B4 Q9H7B4 SMYD3 PTHR12197:SF288 HISTONE-LYSINE N-METHYLTRANSFERASE SMYD HISTONE-LYSINE N-METHYLTRANSFERASE SMYD3 histone H3 methyltransferase activity#GO:0140938;histone modifying activity#GO:0140993;lysine N-methyltransferase activity#GO:0016278;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;N-methyltransferase activity#GO:0008170;protein-lysine N-methyltransferase activity#GO:0016279;histone methyltransferase activity#GO:0042054;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein methyltransferase activity#GO:0008276;histone H3K36 methyltransferase activity#GO:0046975 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;negative regulation of macromolecule biosynthetic process#GO:0010558;heart development#GO:0007507;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;multicellular organism development#GO:0007275;animal organ development#GO:0048513;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;circulatory system development#GO:0072359;negative regulation of metabolic process#GO:0009892;animal gross anatomical part developmental process#GO:0160108;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 histone modifying enzyme#PC00261 HUMAN|HGNC=3060|UniProtKB=Q86Y01 Q86Y01 DTX1 PTHR12622:SF7 DELTEX-RELATED E3 UBIQUITIN-PROTEIN LIGASE DTX1 catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630 biological regulation#GO:0065007;multicellular organismal process#GO:0032501;glial cell differentiation#GO:0010001;ubiquitin-dependent protein catabolic process#GO:0006511;neurogenesis#GO:0022008;macromolecule metabolic process#GO:0043170;Notch signaling pathway#GO:0007219;cellular developmental process#GO:0048869;developmental process#GO:0032502;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;modification-dependent protein catabolic process#GO:0019941;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;system development#GO:0048731;cell communication#GO:0007154;anatomical structure development#GO:0048856;protein metabolic process#GO:0019538;proteasomal protein catabolic process#GO:0010498;nervous system development#GO:0007399;signal transduction#GO:0007165;cellular process#GO:0009987;gliogenesis#GO:0042063;multicellular organism development#GO:0007275;cell surface receptor signaling pathway#GO:0007166;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;signaling#GO:0023052;response to stimulus#GO:0050896;cell differentiation#GO:0030154;regulation of biological process#GO:0050789;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;animal gross anatomical part developmental process#GO:0160108 nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=27223|UniProtKB=Q96EV2 Q96EV2 RBM33 PTHR22014:SF2 RNA-BINDING PROTEIN 33 RNA-BINDING PROTEIN 33 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 HUMAN|HGNC=21382|UniProtKB=A6NGQ2 A6NGQ2 OOEP PTHR19447:SF14 OOCYTE-EXPRESSED PROTEIN HOMOLOG-RELATED OOCYTE-EXPRESSED PROTEIN HOMOLOG binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 establishment or maintenance of apical/basal cell polarity#GO:0035088;establishment or maintenance of cell polarity#GO:0007163;establishment or maintenance of bipolar cell polarity#GO:0061245;developmental process#GO:0032502;pattern specification process#GO:0007389;anatomical structure development#GO:0048856;multicellular organism development#GO:0007275;embryonic pattern specification#GO:0009880;cellular process#GO:0009987;multicellular organismal process#GO:0032501;embryo development#GO:0009790 HUMAN|HGNC=21683|UniProtKB=Q6IQ20 Q6IQ20 NAPEPLD PTHR15032:SF38 N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D hydrolase activity#GO:0016787;lipase activity#GO:0016298;phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578;phospholipase activity#GO:0120569;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;glycerophospholipase activity#GO:0004620 glycerophospholipid metabolic process#GO:0006650;small molecule metabolic process#GO:0044281;glycerolipid metabolic process#GO:0046486;phospholipid metabolic process#GO:0006644;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;alcohol metabolic process#GO:0006066;metabolic process#GO:0008152;lipid metabolic process#GO:0006629 intracellular anatomical structure#GO:0005622;cell body#GO:0044297;neuron projection#GO:0043005;somatodendritic compartment#GO:0036477;cell projection#GO:0042995;neuronal cell body#GO:0043025;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165 phospholipase#PC00186 HUMAN|HGNC=20605|UniProtKB=Q60I27 Q60I27 ALS2CL PTHR46089:SF1 ALSIN HOMOLOG ALS2 C-TERMINAL-LIKE PROTEIN nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772;binding#GO:0005488;guanyl-nucleotide exchange factor activity#GO:0005085;enzyme binding#GO:0019899;enzyme regulator activity#GO:0030234;small GTPase binding#GO:0031267;protein binding#GO:0005515 intracellular transport#GO:0046907;transport#GO:0006810;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;endosomal transport#GO:0016197;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192 intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410 HUMAN|HGNC=17146|UniProtKB=Q9Y2Y0 Q9Y2Y0 ARL2BP PTHR15487:SF5 ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-BINDING PROTEIN ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-BINDING PROTEIN mitochondrion#GO:0005739;mitochondrial envelope#GO:0005740;organelle envelope#GO:0031967;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;mitochondrial intermembrane space#GO:0005758;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=17277|UniProtKB=Q96KR1 Q96KR1 ZFR PTHR45762:SF21 ZINC FINGER RNA-BINDING PROTEIN ZINC FINGER RNA-BINDING PROTEIN binding#GO:0005488;nucleic acid binding#GO:0003676;double-stranded RNA binding#GO:0003725;RNA binding#GO:0003723;single-stranded RNA binding#GO:0003727 RNA metabolism protein#PC00031 HUMAN|HGNC=2739|UniProtKB=O60231 O60231 DHX16 PTHR18934:SF83 ATP-DEPENDENT RNA HELICASE PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;ATP-dependent activity#GO:0140657;helicase activity#GO:0004386;isomerase activity#GO:0016853;catalytic activity#GO:0003824;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;macromolecular conformation isomerase activity#GO:0120543 spliceosomal complex#GO:0005681;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;catalytic step 2 spliceosome#GO:0071013;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 RNA metabolism protein#PC00031;RNA helicase#PC00032 HUMAN|HGNC=4905|UniProtKB=Q9UM44 Q9UM44 HHLA2 PTHR24100:SF106 BUTYROPHILIN HERV-H LTR-ASSOCIATING PROTEIN 2 protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 regulation of biological process#GO:0050789;immune response-regulating signaling pathway#GO:0002764;response to stimulus#GO:0050896;signaling#GO:0023052;immune system process#GO:0002376;positive regulation of immune system process#GO:0002684;activation of immune response#GO:0002253;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;antigen receptor-mediated signaling pathway#GO:0050851;regulation of multicellular organismal process#GO:0051239;cell surface receptor signaling pathway#GO:0007166;immune response-activating signaling pathway#GO:0002757;cellular response to stimulus#GO:0051716;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;immune response-activating cell surface receptor signaling pathway#GO:0002429;regulation of immune response#GO:0050776;cell communication#GO:0007154;regulation of cytokine production#GO:0001817;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of response to stimulus#GO:0048584;immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007;T cell receptor signaling pathway#GO:0050852;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell surface#GO:0009986;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;membrane#GO:0016020 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=13733|UniProtKB=Q9H251 Q9H251 CDH23 PTHR24027:SF425 CADHERIN-23 CADHERIN-23 binding#GO:0005488;cell adhesion molecule binding#GO:0050839;protein binding#GO:0005515;beta-catenin binding#GO:0008013 cell migration#GO:0016477;cell motility#GO:0048870;cellular process#GO:0009987;cell adhesion#GO:0007155;cell-cell adhesion#GO:0098609 extrinsic component of plasma membrane#GO:0019897;extrinsic component of membrane#GO:0019898;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 cell adhesion molecule#PC00069;cadherin#PC00057 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HUMAN|HGNC=1092|UniProtKB=P58012 P58012 FOXL2 PTHR11829:SF411 FORKHEAD BOX PROTEIN FORKHEAD BOX PROTEIN L2 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=13477|UniProtKB=A0A1B0GUS4 A0A1B0GUS4 UBE2L5 PTHR24068:SF170 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2 L5 catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;ubiquitin conjugating enzyme activity#GO:0061631;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein conjugating enzyme activity#GO:0061650 macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;cellular process#GO:0009987;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;protein modification by small protein conjugation or removal#GO:0070647;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;catabolic process#GO:0009056;protein K11-linked ubiquitination#GO:0070979;primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein polyubiquitination#GO:0000209;modification-dependent protein catabolic process#GO:0019941;protein modification by small protein conjugation#GO:0032446 ubiquitin-protein ligase#PC00234 Parkinson disease#P00049>UbcH7#P01224;Ubiquitin proteasome pathway#P00060>E2#P01491 HUMAN|HGNC=6513|UniProtKB=Q14847 Q14847 LASP1 PTHR46218:SF2 LASP LIM AND SH3 DOMAIN PROTEIN 1 protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;actin filament binding#GO:0051015 cellular anatomical structure#GO:0110165;cell junction#GO:0030054;anchoring junction#GO:0070161;cell-substrate junction#GO:0030055;focal adhesion#GO:0005925 HUMAN|HGNC=10467|UniProtKB=Q16799 Q16799 RTN1 PTHR45799:SF10 RETICULON-LIKE PROTEIN RETICULON-1 organelle organization#GO:0006996;cellular component organization#GO:0016043;endoplasmic reticulum organization#GO:0007029;cellular process#GO:0009987;endoplasmic reticulum tubular network organization#GO:0071786;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;endoplasmic reticulum membrane organization#GO:0090158;cellular component organization or biogenesis#GO:0071840 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827 HUMAN|HGNC=171|UniProtKB=Q04771 Q04771 ACVR1 PTHR23255:SF69 TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II ACTIVIN RECEPTOR TYPE-1 molecular transducer activity#GO:0060089;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity, acting on a protein#GO:0140096;transmembrane signaling receptor activity#GO:0004888;protein serine/threonine kinase activity#GO:0004674;binding#GO:0005488;protein kinase activity#GO:0004672;protein binding#GO:0005515;transmembrane receptor protein serine/threonine kinase activity#GO:0004675;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transforming growth factor beta receptor activity#GO:0005024;kinase activity#GO:0016301;transferase activity#GO:0016740;signaling receptor activity#GO:0038023 multicellular organism development#GO:0007275;animal organ development#GO:0048513;cellular response to BMP stimulus#GO:0071773;cell surface receptor signaling pathway#GO:0007166;heart development#GO:0007507;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;signal transduction#GO:0007165;cellular process#GO:0009987;transforming growth factor beta receptor signaling pathway#GO:0007179;cellular response to growth factor stimulus#GO:0071363;animal gross anatomical part developmental process#GO:0160108;signaling#GO:0023052;response to stimulus#GO:0050896;cell differentiation#GO:0030154;cellular response to endogenous stimulus#GO:0071495;circulatory system development#GO:0072359;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;cellular developmental process#GO:0048869;developmental process#GO:0032502;response to BMP#GO:0071772;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regionalization#GO:0003002;system development#GO:0048731;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;pattern specification process#GO:0007389;response to transforming growth factor beta#GO:0071559;response to growth factor#GO:0070848;regulation of cellular process#GO:0050794;dorsal/ventral pattern formation#GO:0009953;BMP signaling pathway#GO:0030509;cellular response to transforming growth factor beta stimulus#GO:0071560;cellular response to stimulus#GO:0051716 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane#GO:0016020;membrane protein complex#GO:0098796;signaling receptor complex#GO:0043235 serine/threonine protein kinase receptor#PC00205 TGF-beta signaling pathway#P00052>TGFbetareceptor I#P01278;TGF-beta signaling pathway#P00052>TGFbetareceptors#P01283 HUMAN|HGNC=4725|UniProtKB=P0C0S8 P0C0S8 H2AC11 PTHR23430:SF245 HISTONE H2A HISTONE H2A TYPE 1 structural molecule activity#GO:0005198 negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of gene expression, epigenetic#GO:0045814;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;epigenetic regulation of gene expression#GO:0040029;regulation of macromolecule biosynthetic process#GO:0010556;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;heterochromatin organization#GO:0070828;negative regulation of biosynthetic process#GO:0009890;chromatin organization#GO:0006325;biological regulation#GO:0065007;cellular component assembly#GO:0022607;heterochromatin formation#GO:0031507;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255 intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;chromosome#GO:0005694;nucleus#GO:0005634;chromatin#GO:0000785;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;protein-DNA complex#GO:0032993;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;nucleosome#GO:0000786 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=19364|UniProtKB=Q8IZC4 Q8IZC4 RTKN2 PTHR21538:SF21 ANILLIN/RHOTEKIN RTKN RHOTEKIN-2 hemopoiesis#GO:0030097;biological regulation#GO:0065007;positive regulation of cellular process#GO:0048522;mitotic cell cycle process#GO:1903047;cellular developmental process#GO:0048869;developmental process#GO:0032502;septin cytoskeleton organization#GO:0032185;mitotic cytokinesis#GO:0000281;regulation of cellular process#GO:0050794;actin cytoskeleton organization#GO:0030036;mitotic cell cycle#GO:0000278;cell division#GO:0051301;cell cycle#GO:0007049;anatomical structure development#GO:0048856;regulation of cell population proliferation#GO:0042127;cortical actin cytoskeleton organization#GO:0030866;actin filament-based process#GO:0030029;cortical cytoskeleton organization#GO:0030865;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;actomyosin contractile ring assembly#GO:0000915;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular component organization or biogenesis#GO:0071840;cell development#GO:0048468;actomyosin structure organization#GO:0031032;cell differentiation#GO:0030154;cell cycle process#GO:0022402;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;positive regulation of cell population proliferation#GO:0008284;cytoskeleton-dependent cytokinesis#GO:0061640;septin ring organization#GO:0031106;cytokinetic process#GO:0032506;cytokinesis#GO:0000910 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cell cortex#GO:0005938;cortical cytoskeleton#GO:0030863;actin cytoskeleton#GO:0015629;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cortical actin cytoskeleton#GO:0030864;cytoplasm#GO:0005737;cell division site#GO:0032153;intracellular membraneless organelle#GO:0043232;cell periphery#GO:0071944;membraneless organelle#GO:0043228;actomyosin contractile ring#GO:0005826;cytoskeleton#GO:0005856;contractile ring#GO:0070938 non-motor actin binding protein#PC00165 HUMAN|HGNC=6439|UniProtKB=P35908 P35908 KRT2 PTHR45616:SF14 GATA-TYPE DOMAIN-CONTAINING PROTEIN KERATIN, TYPE II CYTOSKELETAL 2 EPIDERMAL structural molecule activity#GO:0005198 anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;intermediate filament-based process#GO:0045103;animal gross anatomical part developmental process#GO:0160108;keratinocyte differentiation#GO:0030216;intermediate filament organization#GO:0045109;intermediate filament cytoskeleton organization#GO:0045104;cell differentiation#GO:0030154;cellular component organization#GO:0016043;cellular component organization or biogenesis#GO:0071840;animal organ development#GO:0048513;cellular developmental process#GO:0048869;epidermis development#GO:0008544;developmental process#GO:0032502;epithelium development#GO:0060429;tissue development#GO:0009888;multicellular organismal process#GO:0032501;epidermal cell differentiation#GO:0009913;epithelial cell differentiation#GO:0030855;skin development#GO:0043588;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular process#GO:0009987 intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;intermediate filament#GO:0005882;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228 HUMAN|HGNC=9361|UniProtKB=P10124 P10124 SRGN PTHR17178:SF0 SECRETORY GRANULE PROTEOGLYCAN CORE PROTEIN SERGLYCIN vesicle organization#GO:0016050;intracellular protein localization#GO:0008104;cellular component organization or biogenesis#GO:0071840;endomembrane system organization#GO:0010256;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;macromolecule localization#GO:0033036;organelle organization#GO:0006996;cellular localization#GO:0051641;localization#GO:0051179;cell communication#GO:0007154;signaling#GO:0023052;protein localization to organelle#GO:0033365;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cell death#GO:0008219;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;programmed cell death#GO:0012501;cellular component organization#GO:0016043 lytic vacuole#GO:0000323;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;endomembrane system#GO:0012505;vacuole#GO:0005773;cytoplasm#GO:0005737;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;lysosome#GO:0005764 HUMAN|HGNC=6810|UniProtKB=O15480 O15480 MAGEB3 PTHR11736:SF53 MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN MELANOMA-ASSOCIATED ANTIGEN B3 negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 scaffold/adaptor protein#PC00226 HUMAN|HGNC=15908|UniProtKB=P61599 P61599 NAA20 PTHR45910:SF1 N-ALPHA-ACETYLTRANSFERASE 20 N-ALPHA-ACETYLTRANSFERASE 20 N-acetyltransferase activity#GO:0008080;acetyltransferase activity#GO:0016407;acyltransferase activity#GO:0016746;protein N-acyltransferase activity#GO:0140186;catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;protein N-acetyltransferase activity#GO:0034212;catalytic activity, acting on a protein#GO:0140096;protein-N-terminal amino-acid acetyltransferase activity#GO:0004596 regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;biological regulation#GO:0065007;regulation of actin cytoskeleton organization#GO:0032956;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794;regulation of actin filament-based process#GO:0032970 intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;acetyltransferase complex#GO:1902493;protein acetyltransferase complex#GO:0031248;transferase complex#GO:1990234;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737 acetyltransferase#PC00038 HUMAN|HGNC=32044|UniProtKB=Q5JVX7 Q5JVX7 C1orf141 PTHR36873:SF1 HYPOTHETICAL GENE SUPPORTED BY BC079057 SIMILAR TO HUMAN CHROMOSOME 1 OPEN READING FRAME 141 HUMAN|HGNC=20457|UniProtKB=P50876 P50876 RNF144A PTHR11685:SF99 RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING E3 UBIQUITIN-PROTEIN LIGASE RNF144A catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;enzyme binding#GO:0019899;acyltransferase activity#GO:0016746;binding#GO:0005488;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;protein binding#GO:0005515 catabolic process#GO:0009056;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;ubiquitin ligase complex#GO:0000151;transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=13097|UniProtKB=Q06732 Q06732 ZNF33B PTHR24376:SF230 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 33B negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=11812|UniProtKB=O15164 O15164 TRIM24 PTHR45915:SF4 TRANSCRIPTION INTERMEDIARY FACTOR TRANSCRIPTION INTERMEDIARY FACTOR 1-ALPHA ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;ubiquitin protein ligase activity#GO:0061630;transcription regulator activity#GO:0140110;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transcription coactivator activity#GO:0003713;transferase activity#GO:0016740;catalytic activity#GO:0003824;transcription coregulator activity#GO:0003712 regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;regulation of RNA metabolic process#GO:0051252;regulation of biological quality#GO:0065008;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;regulation of protein stability#GO:0031647 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694;nucleus#GO:0005634;chromatin#GO:0000785;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=2485|UniProtKB=Q12996 Q12996 CSTF3 PTHR19980:SF0 RNA CLEAVAGE STIMULATION FACTOR CLEAVAGE STIMULATION FACTOR SUBUNIT 3 binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723 nucleobase-containing compound biosynthetic process#GO:0034654;mRNA 3'-end processing#GO:0031124;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774 mRNA cleavage factor complex#GO:0005849;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 RNA processing factor#PC00147;mRNA polyadenylation factor#PC00146 HUMAN|HGNC=2509|UniProtKB=P35221 P35221 CTNNA1 PTHR18914:SF24 ALPHA CATENIN CATENIN ALPHA-1 binding#GO:0005488;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;actin filament binding#GO:0051015;protein binding#GO:0005515;beta-catenin binding#GO:0008013;protein-containing complex binding#GO:0044877 cell motility#GO:0048870;cell migration#GO:0016477;cell adhesion#GO:0007155;cellular process#GO:0009987;cell-cell adhesion#GO:0098609 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane protein complex#GO:0098796;cell-cell junction#GO:0005911;membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;cell junction#GO:0030054;extrinsic component of membrane#GO:0019898;extrinsic component of plasma membrane#GO:0019897;adherens junction#GO:0005912;anchoring junction#GO:0070161 non-motor actin binding protein#PC00165 Wnt signaling pathway#P00057>alpha-catenin#P01471;Alzheimer disease-presenilin pathway#P00004>alpha-catenin#P00133;Cadherin signaling pathway#P00012>alpha-catenin#P00467 HUMAN|HGNC=8157|UniProtKB=Q99720 Q99720 SIGMAR1 PTHR10868:SF4 SIGMA 1-TYPE OPIOID RECEPTOR-RELATED SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of response to endoplasmic reticulum stress#GO:1905897;regulation of biological process#GO:0050789;regulation of neuron apoptotic process#GO:0043523;regulation of programmed cell death#GO:0043067;regulation of cellular response to stress#GO:0080135;regulation of apoptotic process#GO:0042981;regulation of response to stimulus#GO:0048583;regulation of response to stress#GO:0080134 postsynaptic density#GO:0014069;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;postsynapse#GO:0098794;intracellular membrane-bounded organelle#GO:0043231;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;asymmetric synapse#GO:0032279;endoplasmic reticulum#GO:0005783;cell junction#GO:0030054;cytoplasm#GO:0005737;endomembrane system#GO:0012505;neuron to neuron synapse#GO:0098984;postsynaptic specialization#GO:0099572 transmembrane signal receptor#PC00197 HUMAN|HGNC=29071|UniProtKB=A3KMH1 A3KMH1 VWA8 PTHR21610:SF9 VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 8 VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 8 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=26089|UniProtKB=Q9NWK9 Q9NWK9 ZNHIT6 PTHR13483:SF3 BOX C_D SNORNA PROTEIN 1-RELATED BOX C_D SNORNA PROTEIN 1 biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;gene expression#GO:0010467;maturation of LSU-rRNA#GO:0000470;cellular component assembly#GO:0022607;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;protein-containing complex organization#GO:0043933;protein-RNA complex organization#GO:0071826;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;protein-containing complex assembly#GO:0065003;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;protein-RNA complex assembly#GO:0022618;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;ribosomal large subunit biogenesis#GO:0042273 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229 HUMAN|HGNC=28369|UniProtKB=Q86W42 Q86W42 THOC6 PTHR44411:SF1 THO COMPLEX SUBUNIT 6 HOMOLOG THO COMPLEX SUBUNIT 6 nitrogen compound transport#GO:0071705;macromolecule localization#GO:0033036;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907;metabolic process#GO:0008152;transport#GO:0006810;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;RNA localization#GO:0006403;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;establishment of RNA localization#GO:0051236;mRNA transport#GO:0051028;nucleocytoplasmic transport#GO:0006913;cellular localization#GO:0051641;nucleic acid transport#GO:0050657;mRNA export from nucleus#GO:0006406;localization#GO:0051179;nuclear export#GO:0051168;nuclear transport#GO:0051169 intracellular organelle#GO:0043229;transcription export complex#GO:0000346;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;THO complex#GO:0000347 HUMAN|HGNC=19190|UniProtKB=Q96N67 Q96N67 DOCK7 PTHR23317:SF78 DEDICATOR OF CYTOKINESIS DOCK DEDICATOR OF CYTOKINESIS PROTEIN 7 molecular function regulator activity#GO:0098772;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;guanyl-nucleotide exchange factor activity#GO:0005085 anatomical structure development#GO:0048856;system development#GO:0048731;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;regulation of response to stimulus#GO:0048583;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;axon development#GO:0061564;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;plasma membrane bounded cell projection organization#GO:0120036;animal gross anatomical part developmental process#GO:0160108;regulation of intracellular signal transduction#GO:1902531;generation of neurons#GO:0048699;regulation of signaling#GO:0023051;axonogenesis#GO:0007409;neuron development#GO:0048666;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell morphogenesis#GO:0000902;regulation of Rho protein signal transduction#GO:0035023;cell development#GO:0048468;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cell projection morphogenesis#GO:0048858;regulation of small GTPase mediated signal transduction#GO:0051056;neuron projection development#GO:0031175;cellular process#GO:0009987;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399 G-protein modulator#PC00022;protein-binding activity modulator#PC00095;guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=32305|UniProtKB=Q5VU69 Q5VU69 CFAP141 PTHR35818:SF1 C1ORF189 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 141 HUMAN|HGNC=19627|UniProtKB=A0A2R8YED5 A0A2R8YED5 OR5BS1 PTHR26452:SF805 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5BS1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 sensory perception of chemical stimulus#GO:0007606;sensory perception#GO:0007600;nervous system process#GO:0050877;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;system process#GO:0003008 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=25202|UniProtKB=Q6P4D5 Q6P4D5 PABIR3 PTHR22227:SF3 FAMILY WITH SEQUENCE SIMILARITY 122B ISOFORM X1 PABIR FAMILY MEMBER 1 protein serine/threonine phosphatase inhibitor activity#GO:0004865;protein phosphatase regulator activity#GO:0019888;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;enzyme inhibitor activity#GO:0004857;protein phosphatase inhibitor activity#GO:0004864;phosphatase inhibitor activity#GO:0019212;molecular function regulator activity#GO:0098772;phosphatase regulator activity#GO:0019208 biological regulation#GO:0065007;positive regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032436;regulation of proteasomal protein catabolic process#GO:0061136;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;regulation of primary metabolic process#GO:0080090;regulation of catabolic process#GO:0009894;positive regulation of catabolic process#GO:0009896;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of ubiquitin-dependent protein catabolic process#GO:2000060;regulation of biological process#GO:0050789;positive regulation of proteasomal protein catabolic process#GO:1901800;regulation of protein catabolic process#GO:0042176;positive regulation of protein catabolic process#GO:0045732;positive regulation of metabolic process#GO:0009893;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434;positive regulation of protein metabolic process#GO:0051247 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HUMAN|HGNC=13299|UniProtKB=Q9BXB1 Q9BXB1 LGR4 PTHR24372:SF67 GLYCOPROTEIN HORMONE RECEPTOR LEUCINE-RICH REPEAT-CONTAINING G PROTEIN-COUPLED RECEPTOR 4 G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023 positive regulation of cellular process#GO:0048522;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;regulation of response to stimulus#GO:0048583;positive regulation of canonical Wnt signaling pathway#GO:0090263;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of cell communication#GO:0010646;cell communication#GO:0007154;regulation of canonical Wnt signaling pathway#GO:0060828;response to hormone#GO:0009725;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of Wnt signaling pathway#GO:0030177;response to chemical#GO:0042221;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;cellular response to hormone stimulus#GO:0032870;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;regulation of Wnt signaling pathway#GO:0030111;signaling#GO:0023052;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;hormone-mediated signaling pathway#GO:0009755 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021 HUMAN|HGNC=4403|UniProtKB=P61952 P61952 GNG11 PTHR13809:SF1 GUANINE NUCLEOTIDE-BINDING PROTEIN GAMMA SUBUNIT GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)_G(S)_G(O) SUBUNIT GAMMA-11 hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;molecular function regulator activity#GO:0098772;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924;hydrolase activity#GO:0016787 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane#GO:0016020;cytoplasmic side of plasma membrane#GO:0009898;membrane protein complex#GO:0098796;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;side of membrane#GO:0098552;extrinsic component of plasma membrane#GO:0019897;extrinsic component of membrane#GO:0019898;extrinsic component of cytoplasmic side of plasma membrane#GO:0031234;cytoplasmic side of membrane#GO:0098562;catalytic complex#GO:1902494 heterotrimeric G-protein#PC00117 Metabotropic glutamate receptor group II pathway#P00040>G-protein#P01047;5HT2 type receptor mediated signaling pathway#P04374>G-protein#P04416;Angiotensin II-stimulated signaling through G proteins and beta-arrestin#P05911>Ggamma#P05929;Endogenous cannabinoid signaling#P05730>Ggamma#P05744;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>G-Protein#P01073;Dopamine receptor mediated signaling pathway#P05912>Ggamma#P05967;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>G-Protein#P01085;GABA-B receptor II signaling#P05731>Ggamma#P05754;5HT1 type receptor mediated signaling pathway#P04373>G-protein#P04408 HUMAN|HGNC=4335|UniProtKB=P00367 P00367 GLUD1 PTHR11606:SF25 GLUTAMATE DEHYDROGENASE GLUTAMATE DEHYDROGENASE 1, MITOCHONDRIAL catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;proteinogenic amino acid metabolic process#GO:0170039;amino acid metabolic process#GO:0006520;small molecule catabolic process#GO:0044282;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 Glutamine glutamate conversion#P02745>Glutamate Dehydrogenase#P02967 HUMAN|HGNC=7760|UniProtKB=Q9UQ49 Q9UQ49 NEU3 PTHR10628:SF23 SIALIDASE SIALIDASE-3 hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798 cellular process#GO:0009987;lipid catabolic process#GO:0016042;carbohydrate derivative metabolic process#GO:1901135;oligosaccharide metabolic process#GO:0009311;lipid metabolic process#GO:0006629;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;carbohydrate derivative catabolic process#GO:1901136;carbohydrate metabolic process#GO:0005975;glycolipid metabolic process#GO:0006664;oligosaccharide catabolic process#GO:0009313;catabolic process#GO:0009056;liposaccharide metabolic process#GO:1903509;primary metabolic process#GO:0044238;sphingolipid catabolic process#GO:0030149;ceramide metabolic process#GO:0006672;carbohydrate catabolic process#GO:0016052 membrane#GO:0016020;lysosome#GO:0005764;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vacuole#GO:0005773;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;lytic vacuole#GO:0000323;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 hydrolase#PC00121 HUMAN|HGNC=4279|UniProtKB=P36382 P36382 GJA5 PTHR11984:SF13 CONNEXIN GAP JUNCTION ALPHA-5 PROTEIN passive transmembrane transporter activity#GO:0022803;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;wide pore channel activity#GO:0022829;channel activity#GO:0015267 anatomical structure development#GO:0048856;cell communication#GO:0007154;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;circulatory system development#GO:0072359;regulation of heart contraction#GO:0008016;signaling#GO:0023052;regulation of biological process#GO:0050789;animal organ development#GO:0048513;multicellular organism development#GO:0007275;regulation of system process#GO:0044057;developmental process#GO:0032502;multicellular organismal process#GO:0032501;heart development#GO:0007507;regulation of multicellular organismal process#GO:0051239;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;cellular process#GO:0009987 membrane protein complex#GO:0098796;membrane#GO:0016020;cell-cell junction#GO:0005911;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;cell junction#GO:0030054;anchoring junction#GO:0070161 cell junction protein#PC00070;gap junction#PC00105 HUMAN|HGNC=29089|UniProtKB=Q5T8A7 Q5T8A7 PPP1R26 PTHR15724:SF0 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 26 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 26 phosphatase modulator#PC00184 HUMAN|HGNC=15312|UniProtKB=Q8NGG0 Q8NGG0 OR8J3 PTHR48018:SF41 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 8J3 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;sensory perception#GO:0007600;nervous system process#GO:0050877;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;sensory perception of smell#GO:0007608 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=15749|UniProtKB=Q9NP55 Q9NP55 BPIFA1 PTHR47015:SF1 BPI FOLD-CONTAINING FAMILY A MEMBER 1 BPI FOLD-CONTAINING FAMILY A MEMBER 1 multicellular organismal process#GO:0032501;homeostatic process#GO:0042592;multicellular organismal-level homeostasis#GO:0048871;chemical homeostasis#GO:0048878 HUMAN|HGNC=8725|UniProtKB=Q16822 Q16822 PCK2 PTHR11561:SF11 PHOSPHOENOLPYRUVATE CARBOXYKINASE PHOSPHOENOLPYRUVATE CARBOXYKINASE [GTP], MITOCHONDRIAL carboxy-lyase activity#GO:0016831;catalytic activity#GO:0003824;carbon-carbon lyase activity#GO:0016830;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;transition metal ion binding#GO:0046914;lyase activity#GO:0016829;metal ion binding#GO:0046872;cation binding#GO:0043169 liver development#GO:0001889;cellular response to hormone stimulus#GO:0032870;response to stimulus#GO:0050896;response to carbohydrate#GO:0009743;animal gross anatomical part developmental process#GO:0160108;cellular response to chemical stimulus#GO:0070887;response to monosaccharide#GO:0034284;cellular response to lipid#GO:0071396;carbohydrate biosynthetic process#GO:0016051;cellular process#GO:0009987;alcohol biosynthetic process#GO:0046165;cellular response to oxygen-containing compound#GO:1901701;cellular response to steroid hormone stimulus#GO:0071383;multicellular organism development#GO:0007275;glucose homeostasis#GO:0042593;alcohol metabolic process#GO:0006066;primary metabolic process#GO:0044238;hexose metabolic process#GO:0019318;response to insulin#GO:0032868;cellular response to stimulus#GO:0051716;anatomical structure development#GO:0048856;response to steroid hormone#GO:0048545;response to glucose#GO:0009749;multicellular organismal process#GO:0032501;epithelial cell differentiation#GO:0030855;epithelium development#GO:0060429;response to peptide hormone#GO:0043434;biosynthetic process#GO:0009058;monosaccharide biosynthetic process#GO:0046364;cellular homeostasis#GO:0019725;cellular response to insulin stimulus#GO:0032869;small molecule metabolic process#GO:0044281;cellular response to endogenous stimulus#GO:0071495;cell differentiation#GO:0030154;carboxylic acid metabolic process#GO:0019752;response to hexose#GO:0009746;response to endogenous stimulus#GO:0009719;carbohydrate homeostasis#GO:0033500;intracellular glucose homeostasis#GO:0001678;oxoacid metabolic process#GO:0043436;response to oxygen-containing compound#GO:1901700;response to lipid#GO:0033993;response to chemical#GO:0042221;response to hormone#GO:0009725;response to stress#GO:0006950;gluconeogenesis#GO:0006094;animal organ development#GO:0048513;glucose metabolic process#GO:0006006;monosaccharide metabolic process#GO:0005996;metabolic process#GO:0008152;cellular response to glucose stimulus#GO:0071333;chemical homeostasis#GO:0048878;cellular response to peptide hormone stimulus#GO:0071375;homeostatic process#GO:0042592;carbohydrate metabolic process#GO:0005975;response to starvation#GO:0042594;hexose biosynthetic process#GO:0019319;response to nitrogen compound#GO:1901698;system development#GO:0048731;cellular response to nitrogen compound#GO:1901699;tissue development#GO:0009888;response to nutrient levels#GO:0031667;cellular developmental process#GO:0048869;intracellular chemical homeostasis#GO:0055082;small molecule biosynthetic process#GO:0044283;developmental process#GO:0032502 cytosol#GO:0005829;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 transferase#PC00220;kinase#PC00137;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=3079|UniProtKB=O43812 O43812 DUX1 PTHR46123:SF3 MIX-TYPE HOMEOBOX GENE 1-RELATED DOUBLE HOMEOBOX PROTEIN 1-RELATED RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=23068|UniProtKB=P0DI81 P0DI81 TRAPPC2 PTHR12403:SF1 TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2 TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2-RELATED retrograde transport, endosome to Golgi#GO:0042147;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;cytosolic transport#GO:0016482;intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;transport#GO:0006810;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;endosomal transport#GO:0016197 intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;vesicle#GO:0031982;TRAPPII protein complex#GO:1990071;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;Golgi apparatus#GO:0005794;vesicle tethering complex#GO:0099023;intracellular protein-containing complex#GO:0140535;TRAPP complex#GO:0030008;cytoplasm#GO:0005737;endomembrane system#GO:0012505;protein-containing complex#GO:0032991 membrane traffic protein#PC00150 HUMAN|HGNC=30487|UniProtKB=Q6PK81 Q6PK81 ZNF773 PTHR24377:SF691 IP01015P-RELATED ZINC FINGER PROTEIN 773 DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=6879|UniProtKB=Q16659 Q16659 MAPK6 PTHR24055:SF171 MITOGEN-ACTIVATED PROTEIN KINASE MITOGEN-ACTIVATED PROTEIN KINASE 6 kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 cell surface receptor signaling pathway#GO:0007166;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 non-receptor serine/threonine protein kinase#PC00167 VEGF signaling pathway#P00056>MEK#P01402;PDGF signaling pathway#P00047>ERK#P01143;Angiogenesis#P00005>MEK#P00225;Alzheimer disease-amyloid secretase pathway#P00003>MAPK#P00099;Interleukin signaling pathway#P00036>ERK#P00965;Integrin signalling pathway#P00034>ERK#P00907 HUMAN|HGNC=11021|UniProtKB=P78382 P78382 SLC35A1 PTHR10231:SF66 NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER CMP-SIALIC ACID TRANSPORTER transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;organophosphate ester transmembrane transporter activity#GO:0015605;nucleobase-containing compound transmembrane transporter activity#GO:0015932;carbohydrate derivative transmembrane transporter activity#GO:1901505;nucleotide-sugar transmembrane transporter activity#GO:0005338 transport#GO:0006810;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;nitrogen compound transport#GO:0071705;cellular process#GO:0009987;carbohydrate derivative transport#GO:1901264;nucleotide-sugar transmembrane transport#GO:0015780;organophosphate ester transport#GO:0015748;nucleobase-containing compound transport#GO:0015931 Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane#GO:0016020;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 transporter#PC00227 HUMAN|HGNC=16714|UniProtKB=Q96KN3 Q96KN3 PKNOX2 PTHR11850:SF53 HOMEOBOX PROTEIN TRANSCRIPTION FACTORS HOMEOBOX PROTEIN PKNOX2 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of RNA metabolic process#GO:0051254;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116;DNA-binding transcription factor#PC00218 HUMAN|HGNC=28658|UniProtKB=Q6DCA0 Q6DCA0 AMMECR1L PTHR13016:SF1 AMMECR1 HOMOLOG AMMECR1-LIKE PROTEIN membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=11830|UniProtKB=P04183 P04183 TK1 PTHR11441:SF0 THYMIDINE KINASE THYMIDINE KINASE, CYTOSOLIC kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;deoxynucleoside kinase activity#GO:0019136;nucleobase-containing compound kinase activity#GO:0019205;transferase activity#GO:0016740;catalytic activity#GO:0003824 organophosphate biosynthetic process#GO:0090407;nucleotide metabolic process#GO:0009117;nucleotide biosynthetic process#GO:0009165;nucleoside monophosphate biosynthetic process#GO:0009124;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;nucleoside monophosphate metabolic process#GO:0009123;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;carbohydrate derivative biosynthetic process#GO:1901137;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing small molecule metabolic process#GO:0055086;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;organophosphate metabolic process#GO:0019637;pyrimidine-containing compound metabolic process#GO:0072527;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135 kinase#PC00137;nucleotide kinase#PC00172 Salvage pyrimidine deoxyribonucleotides#P02774>Deoxyuridine kinase#P03146;Salvage pyrimidine deoxyribonucleotides#P02774>Thymidine kinase#P03147 HUMAN|HGNC=24136|UniProtKB=Q8NHY0 Q8NHY0 B4GALNT2 PTHR15046:SF2 GLYCO_TRANS_2-LIKE DOMAIN-CONTAINING PROTEIN N-ACETYLNEURAMINYLGALACTOSYLGLUCOSYL-GLUCOSIDE BETA-1,4-N- ACETYLGALACTOSAMINYLTRANSFERASE 2 UDP-glycosyltransferase activity#GO:0008194;acetylgalactosaminyltransferase activity#GO:0008376;glycosyltransferase activity#GO:0016757;hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;catalytic activity#GO:0003824 UDP-N-acetylglucosamine metabolic process#GO:0006047;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;small molecule metabolic process#GO:0044281;amino sugar metabolic process#GO:0006040;nucleobase-containing compound metabolic process#GO:0006139;nucleotide-sugar metabolic process#GO:0009225;nucleoside phosphate metabolic process#GO:0006753;organophosphate metabolic process#GO:0019637;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987 HUMAN|HGNC=40044|UniProtKB=Q8WW34 Q8WW34 TMEM239 PTHR37356:SF1 TRANSMEMBRANE PROTEIN 239 TRANSMEMBRANE PROTEIN 239 HUMAN|HGNC=30461|UniProtKB=Q68DY1 Q68DY1 ZNF626 PTHR24384:SF249 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED ZINC FINGER PROTEIN 626 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218 HUMAN|HGNC=21537|UniProtKB=Q5T4T6 Q5T4T6 SYCP2L PTHR15607:SF14 SYNAPTONEMAL COMPLEX PROTEIN-RELATED SYNAPTONEMAL COMPLEX PROTEIN 2-LIKE intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687;membrane-bounded organelle#GO:0043227;chromosome#GO:0005694;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;chromosome, centromeric region#GO:0000775;condensed chromosome#GO:0000793;membraneless organelle#GO:0043228;condensed nuclear chromosome#GO:0000794;synaptonemal complex#GO:0000795;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;condensed chromosome, centromeric region#GO:0000779;synaptonemal structure#GO:0099086;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=26022|UniProtKB=Q7L0Y3 Q7L0Y3 TRMT10C PTHR13563:SF5 TRNA (GUANINE-9-) METHYLTRANSFERASE TRNA METHYLTRANSFERASE 10 HOMOLOG C nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723;tRNA binding#GO:0000049 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;tRNA modification#GO:0006400;macromolecule methylation#GO:0043414;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;mitochondrial gene expression#GO:0140053;mitochondrial RNA metabolic process#GO:0000959;RNA methylation#GO:0001510;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;methylation#GO:0032259;tRNA methylation#GO:0030488;mitochondrial RNA processing#GO:0000963;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;gene expression#GO:0010467;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;mitochondrion#GO:0005739;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974 RNA metabolism protein#PC00031;RNA methyltransferase#PC00033 HUMAN|HGNC=17290|UniProtKB=Q6UWB1 Q6UWB1 IL27RA PTHR48423:SF1 INTERLEUKIN-27 RECEPTOR SUBUNIT ALPHA INTERLEUKIN-27 RECEPTOR SUBUNIT ALPHA molecular transducer activity#GO:0060089;immune receptor activity#GO:0140375;signaling receptor activity#GO:0038023;cytokine receptor activity#GO:0004896;transmembrane signaling receptor activity#GO:0004888 negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of immune system process#GO:0002682;negative regulation of response to stimulus#GO:0048585;negative regulation of immune system process#GO:0002683;biological regulation#GO:0065007;regulation of response to stimulus#GO:0048583;regulation of immune response#GO:0050776;negative regulation of immune response#GO:0050777 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 HUMAN|HGNC=4216|UniProtKB=O95390 O95390 GDF11 PTHR11848:SF166 TGF-BETA FAMILY GROWTH_DIFFERENTIATION FACTOR 11 signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;cytokine activity#GO:0005125;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677 response to transforming growth factor beta#GO:0071559;cellular response to growth factor stimulus#GO:0071363;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of biological process#GO:0050789;cellular response to transforming growth factor beta stimulus#GO:0071560;cellular response to stimulus#GO:0051716;response to endogenous stimulus#GO:0009719;signaling#GO:0023052;response to growth factor#GO:0070848;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;signal transduction#GO:0007165;cellular process#GO:0009987;transforming growth factor beta receptor signaling pathway#GO:0007179;biological regulation#GO:0065007;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 growth factor#PC00112 TGF-beta signaling pathway#P00052>TGFbeta#P01286 HUMAN|HGNC=4118|UniProtKB=P51570 P51570 GALK1 PTHR10457:SF7 MEVALONATE KINASE/GALACTOKINASE GALACTOKINASE-RELATED transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;carbohydrate kinase activity#GO:0019200;phosphotransferase activity, alcohol group as acceptor#GO:0016773 cellular process#GO:0009987;metabolic process#GO:0008152;monosaccharide metabolic process#GO:0005996;hexose metabolic process#GO:0019318;primary metabolic process#GO:0044238;carbohydrate metabolic process#GO:0005975;small molecule metabolic process#GO:0044281 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 metabolite interconversion enzyme#PC00262;kinase#PC00137;carbohydrate kinase#PC00065;transferase#PC00220 Fructose galactose metabolism#P02744>Galactokinase#P02960 HUMAN|HGNC=9256|UniProtKB=P45877 P45877 PPIC PTHR11071:SF11 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE C intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HUMAN|HGNC=27337|UniProtKB=Q75V66 Q75V66 ANO5 PTHR12308:SF23 ANOCTAMIN ANOCTAMIN-5 phospholipid scramblase activity#GO:0017128;transporter activity#GO:0005215;molecular carrier activity#GO:0140104;lipid carrier activity#GO:0005319;intramembrane lipid carrier activity#GO:0140303 transport#GO:0006810;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;regulation of membrane lipid distribution#GO:0097035;macromolecule localization#GO:0033036;cellular process#GO:0009987;lipid transport#GO:0006869;membrane organization#GO:0061024;biological regulation#GO:0065007;phospholipid translocation#GO:0045332;phospholipid transport#GO:0015914;lipid localization#GO:0010876;localization#GO:0051179;regulation of biological quality#GO:0065008;cellular component organization#GO:0016043;organophosphate ester transport#GO:0015748;lipid translocation#GO:0034204 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=4596|UniProtKB=Q14833 Q14833 GRM4 PTHR24060:SF23 METABOTROPIC GLUTAMATE RECEPTOR METABOTROPIC GLUTAMATE RECEPTOR 4 adenylate cyclase inhibiting G protein-coupled glutamate receptor activity#GO:0001640;glutamate receptor activity#GO:0008066;transmembrane signaling receptor activity#GO:0004888;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of cell communication#GO:0010646;modulation of chemical synaptic transmission#GO:0050804;signaling#GO:0023052;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cell communication#GO:0007154;regulation of synaptic transmission, glutamatergic#GO:0051966;glutamate receptor signaling pathway#GO:0007215;G protein-coupled receptor signaling pathway#GO:0007186;regulation of signaling#GO:0023051;regulation of trans-synaptic signaling#GO:0099177;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;cell surface receptor signaling pathway#GO:0007166 G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GqPCR#P00730;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;Metabotropic glutamate receptor group III pathway#P00039>mGluR4/6/7/8#P01044;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GoPCR#P00725 HUMAN|HGNC=14471|UniProtKB=Q86WA9 Q86WA9 SLC26A11 PTHR11814:SF282 SULFATE TRANSPORTER SODIUM-INDEPENDENT SULFATE ANION TRANSPORTER transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 cellular process#GO:0009987;monoatomic anion transport#GO:0006820;monoatomic ion transmembrane transport#GO:0034220;monoatomic anion transmembrane transport#GO:0098656;transport#GO:0006810;chloride transport#GO:0006821;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;chloride transmembrane transport#GO:1902476 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227 HUMAN|HGNC=28911|UniProtKB=O60831 O60831 PRAF2 PTHR12859:SF1 PRA1 PROTEIN PRA1 FAMILY PROTEIN 2 cellular anatomical structure#GO:0110165;membrane#GO:0016020 transporter#PC00227;amino acid transporter#PC00046 HUMAN|HGNC=3301|UniProtKB=Q9GZV4 Q9GZV4 EIF5A2 PTHR11673:SF13 TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER EUKARYOTIC TRANSLATION INITIATION FACTOR 5A-2 translation elongation factor activity#GO:0003746;translation factor activity#GO:0180051 gene expression#GO:0010467;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;translational elongation#GO:0006414;metabolic process#GO:0008152;translation#GO:0006412 translation factor#PC00223;translation initiation factor#PC00224;translational protein#PC00263 HUMAN|HGNC=16213|UniProtKB=B1AKI9 B1AKI9 ISM1 PTHR10239:SF30 ISTHMIN-2 ISTHMIN-1 regulation of biological process#GO:0050789;regulation of multicellular organismal development#GO:2000026;negative regulation of biological process#GO:0048519;negative regulation of multicellular organismal process#GO:0051241;regulation of developmental process#GO:0050793;biological regulation#GO:0065007;regulation of multicellular organismal process#GO:0051239;regulation of vasculature development#GO:1901342;regulation of angiogenesis#GO:0045765;negative regulation of angiogenesis#GO:0016525;regulation of anatomical structure morphogenesis#GO:0022603 HUMAN|HGNC=28975|UniProtKB=Q15018 Q15018 ABRAXAS2 PTHR31728:SF1 ABRAXAS FAMILY MEMBER BRISC COMPLEX SUBUNIT ABRAXAS 2 microtubule binding#GO:0008017;binding#GO:0005488;modification-dependent protein binding#GO:0140030;polyubiquitin modification-dependent protein binding#GO:0031593;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;protein binding#GO:0005515 organelle localization#GO:0051640;organelle assembly#GO:0070925;organelle fission#GO:0048285;microtubule cytoskeleton organization#GO:0000226;localization#GO:0051179;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cell cycle#GO:0007049;mitotic cell cycle#GO:0000278;chromosome organization#GO:0051276;mitotic cell cycle process#GO:1903047;spindle organization#GO:0007051;mitotic spindle assembly#GO:0090307;mitotic sister chromatid segregation#GO:0000070;nuclear division#GO:0000280;mitotic nuclear division#GO:0140014;cell cycle process#GO:0022402;sister chromatid segregation#GO:0000819;nuclear chromosome segregation#GO:0098813;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;mitotic spindle organization#GO:0007052;chromosome segregation#GO:0007059;metaphase chromosome alignment#GO:0051310;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;spindle assembly#GO:0051225;attachment of spindle microtubules to kinetochore#GO:0008608;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;chromosome localization#GO:0050000;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=7371|UniProtKB=Q13421 Q13421 MSLN PTHR23412:SF6 STEREOCILIN RELATED MESOTHELIN cell-substrate adhesion#GO:0031589;cellular process#GO:0009987;cell adhesion#GO:0007155;cell-matrix adhesion#GO:0007160 cell surface#GO:0009986;cellular anatomical structure#GO:0110165 cell adhesion molecule#PC00069 HUMAN|HGNC=6358|UniProtKB=O43240 O43240 KLK10 PTHR24271:SF66 KALLIKREIN-RELATED KALLIKREIN-10 catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;serine-type peptidase activity#GO:0008236 primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;secretory vesicle#GO:0099503;membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;extracellular region#GO:0005576 serine protease#PC00203 HUMAN|HGNC=6395|UniProtKB=P52292 P52292 KPNA2 PTHR23316:SF12 IMPORTIN ALPHA IMPORTIN SUBUNIT ALPHA-1 nucleocytoplasmic carrier activity#GO:0140142;molecular carrier activity#GO:0140104 localization#GO:0051179;NLS-bearing protein import into nucleus#GO:0006607;cellular localization#GO:0051641;nuclear transport#GO:0051169;protein import into nucleus#GO:0006606;protein transport#GO:0015031;nucleocytoplasmic transport#GO:0006913;protein localization to organelle#GO:0033365;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810;macromolecule localization#GO:0033036;import into nucleus#GO:0051170;protein localization to nucleus#GO:0034504;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 transporter#PC00227 HUMAN|HGNC=5889|UniProtKB=A0A075B6J9 A0A075B6J9 IGLV2-18 PTHR23267:SF491 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN LAMBDA VARIABLE 2-18-RELATED immune system process#GO:0002376;immune response#GO:0006955;response to stimulus#GO:0050896 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=19094|UniProtKB=Q96RQ9 Q96RQ9 IL4I1 PTHR10742:SF21 FLAVIN MONOAMINE OXIDASE L-AMINO-ACID OXIDASE oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 cellular process#GO:0009987;metabolic process#GO:0008152;primary metabolic process#GO:0044238;amino acid metabolic process#GO:0006520;catabolic process#GO:0009056 oxidase#PC00175 5-Hydroxytryptamine degredation#P04372>Monoamine Oxidase#P04401 HUMAN|HGNC=20662|UniProtKB=Q6NUK1 Q6NUK1 SLC25A24 PTHR24089:SF770 SOLUTE CARRIER FAMILY 25 MITOCHONDRIAL ADENYL NUCLEOTIDE ANTIPORTER SLC25A24 organophosphate ester transmembrane transporter activity#GO:0015605;nucleobase-containing compound transmembrane transporter activity#GO:0015932;carbohydrate derivative transmembrane transporter activity#GO:1901505;phosphate transmembrane transporter activity#GO:0005315;active transmembrane transporter activity#GO:0022804;purine nucleotide transmembrane transporter activity#GO:0015216;antiporter activity#GO:0015297;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 organophosphate ester transport#GO:0015748;nucleobase-containing compound transport#GO:0015931;nitrogen compound transport#GO:0071705;carbohydrate derivative transport#GO:1901264;cellular process#GO:0009987;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739 mitochondrial carrier protein#PC00158;secondary carrier transporter#PC00258 HUMAN|HGNC=30181|UniProtKB=Q9BWC9 Q9BWC9 CCDC106 PTHR16477:SF2 COILED-COIL DOMAIN-CONTAINING PROTEIN 106 COILED-COIL DOMAIN-CONTAINING PROTEIN 106 nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=30451|UniProtKB=Q6ZT89 Q6ZT89 SLC25A48 PTHR45624:SF7 MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED SOLUTE CARRIER FAMILY 25 MEMBER 48 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 transporter#PC00227 HUMAN|HGNC=6861|UniProtKB=P80192 P80192 MAP3K9 PTHR44329:SF35 SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 9 protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;MAP kinase kinase kinase activity#GO:0004709;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824 cell communication#GO:0007154;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 Gonadotropin-releasing hormone receptor pathway#P06664>MAP3Ks#P06834 HUMAN|HGNC=11896|UniProtKB=P21580 P21580 TNFAIP3 PTHR13367:SF3 UBIQUITIN THIOESTERASE TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 3 ubiquitin-like protein transferase activity#GO:0019787;deubiquitinase activity#GO:0101005;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;hydrolase activity#GO:0016787;cysteine-type deubiquitinase activity#GO:0004843;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;transferase activity#GO:0016740;peptidase activity#GO:0008233;aminoacyltransferase activity#GO:0016755;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity, acting on a protein#GO:0140096 regulation of response to stress#GO:0080134;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of innate immune response#GO:0045088;positive regulation of canonical Wnt signaling pathway#GO:0090263;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;regulation of canonical NF-kappaB signal transduction#GO:0043122;positive regulation of cellular process#GO:0048522;negative regulation of response to stimulus#GO:0048585;positive regulation of response to stimulus#GO:0048584;post-translational protein modification#GO:0043687;regulation of signal transduction#GO:0009966;negative regulation of immune system process#GO:0002683;biological regulation#GO:0065007;regulation of defense response#GO:0031347;regulation of inflammatory response#GO:0050727;negative regulation of immune response#GO:0050777;regulation of immune response#GO:0050776;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;protein modification process#GO:0036211;positive regulation of signal transduction#GO:0009967;modification-dependent protein catabolic process#GO:0019941;positive regulation of cell communication#GO:0010647;negative regulation of defense response#GO:0031348;negative regulation of inflammatory response#GO:0050728;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;negative regulation of canonical NF-kappaB signal transduction#GO:0043124;catabolic process#GO:0009056;regulation of response to biotic stimulus#GO:0002831;regulation of cell communication#GO:0010646;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;regulation of canonical Wnt signaling pathway#GO:0060828;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;regulation of response to external stimulus#GO:0032101;positive regulation of Wnt signaling pathway#GO:0030177;negative regulation of innate immune response#GO:0045824;negative regulation of signal transduction#GO:0009968;negative regulation of response to external stimulus#GO:0032102;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;protein modification by small protein conjugation or removal#GO:0070647;modification-dependent macromolecule catabolic process#GO:0043632;regulation of signaling#GO:0023051;protein catabolic process#GO:0030163;positive regulation of signaling#GO:0023056;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of Wnt signaling pathway#GO:0030111 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 cysteine protease#PC00081;protease#PC00190 Toll receptor signaling pathway#P00054>A20#P01348 HUMAN|HGNC=34511|UniProtKB=Q6ZVS7 Q6ZVS7 CFAP144P1 PTHR33865:SF1 PROTEIN FAM183B PROTEIN CFAP144P1 membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cilium#GO:0005929;ciliary base#GO:0097546 HUMAN|HGNC=16059|UniProtKB=O96013 O96013 PAK4 PTHR48015:SF17 SERINE/THREONINE-PROTEIN KINASE TAO SERINE_THREONINE-PROTEIN KINASE PAK 4 transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 response to starvation#GO:0042594;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of cell communication#GO:0010646;regulation of intracellular signal transduction#GO:1902531;cellular response to stress#GO:0033554;regulation of signaling#GO:0023051;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;response to nutrient levels#GO:0031667;response to stress#GO:0006950;signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;cellular response to starvation#GO:0009267;regulation of MAPK cascade#GO:0043408;cellular response to nutrient levels#GO:0031669;regulation of response to stimulus#GO:0048583 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 Cytoskeletal regulation by Rho GTPase#P00016>PAK#P00517;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PAK#P00837 HUMAN|HGNC=30293|UniProtKB=Q8WZ71 Q8WZ71 TMEM158 PTHR38324:SF1 TRANSMEMBRANE PROTEIN 158 TRANSMEMBRANE PROTEIN 158 binding#GO:0005488;peptide binding#GO:0042277 HUMAN|HGNC=9181|UniProtKB=Q9Y253 Q9Y253 POLH PTHR45873:SF1 DNA POLYMERASE ETA DNA POLYMERASE ETA DNA-directed DNA polymerase activity#GO:0003887;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on DNA#GO:0140097;DNA polymerase activity#GO:0034061 nucleobase-containing compound biosynthetic process#GO:0034654;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA damage tolerance#GO:0006301;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;response to stress#GO:0006950;cellular process#GO:0009987;response to radiation#GO:0009314;macromolecule biosynthetic process#GO:0009059;DNA biosynthetic process#GO:0071897;translesion synthesis#GO:0019985;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;cellular response to stress#GO:0033554;nucleic acid biosynthetic process#GO:0141187;DNA synthesis involved in DNA replication#GO:0090592;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;response to abiotic stimulus#GO:0009628;cellular response to stimulus#GO:0051716;DNA replication#GO:0006260;response to stimulus#GO:0050896 intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;site of DNA damage#GO:0090734;chromosome#GO:0005694;site of double-strand break#GO:0035861;nucleus#GO:0005634;replication fork#GO:0005657;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232 DNA metabolism protein#PC00009 HUMAN|HGNC=20567|UniProtKB=O75414 O75414 NME6 PTHR46956:SF1 NUCLEOSIDE DIPHOSPHATE KINASE 6 NUCLEOSIDE DIPHOSPHATE KINASE 6, MITOCHONDRIAL phosphotransferase activity, phosphate group as acceptor#GO:0016776;nucleoside diphosphate kinase activity#GO:0004550;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;nucleobase-containing compound kinase activity#GO:0019205;transferase activity#GO:0016740;catalytic activity#GO:0003824 negative regulation of mitotic cell cycle#GO:0045930;negative regulation of cellular component organization#GO:0051129;negative regulation of organelle organization#GO:0010639;negative regulation of biological process#GO:0048519;regulation of organelle organization#GO:0033043;negative regulation of mitotic nuclear division#GO:0045839;regulation of growth#GO:0040008;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of cell cycle#GO:0051726;negative regulation of cellular process#GO:0048523;negative regulation of cell cycle process#GO:0010948;negative regulation of cell cycle#GO:0045786;regulation of mitotic nuclear division#GO:0007088;regulation of mitotic cell cycle#GO:0007346;regulation of cell growth#GO:0001558;negative regulation of nuclear division#GO:0051784;regulation of nuclear division#GO:0051783;negative regulation of cell growth#GO:0030308;regulation of cell cycle process#GO:0010564;biological regulation#GO:0065007 mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;kinase#PC00137;transferase#PC00220 De novo purine biosynthesis#P02738>dADP kinase#P02907;De novo purine biosynthesis#P02738>GDP kinase#P02891 HUMAN|HGNC=15209|UniProtKB=Q8NGK2 Q8NGK2 OR52B4 PTHR26450:SF89 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 52B4 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=26256|UniProtKB=Q8TB73 Q8TB73 NDNF PTHR14619:SF1 NEURON-DERIVED NEUROTROPHIC FACTOR PROTEIN NDNF heparin binding#GO:0008201;binding#GO:0005488;glycosaminoglycan binding#GO:0005539;carbohydrate derivative binding#GO:0097367 external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043;extracellular structure organization#GO:0043062 HUMAN|HGNC=18643|UniProtKB=Q8IWZ8 Q8IWZ8 SUGP1 PTHR23340:SF3 ARGININE/SERINE RICH SPLICING FACTOR SF4/14 SURP AND G-PATCH DOMAIN-CONTAINING PROTEIN 1 nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 RNA processing factor#PC00147;RNA splicing factor#PC00148 HUMAN|HGNC=6930|UniProtKB=Q01718 Q01718 MC2R PTHR22750:SF3 G-PROTEIN COUPLED RECEPTOR ADRENOCORTICOTROPIC HORMONE RECEPTOR transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930 cell communication#GO:0007154;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021 HUMAN|HGNC=26890|UniProtKB=Q8N2M4 Q8N2M4 TMEM86A PTHR31885:SF9 GH04784P LYSOPLASMALOGENASE TMEM86A catalytic activity#GO:0003824;hydrolase activity#GO:0016787 cellular anatomical structure#GO:0110165;membrane#GO:0016020 HUMAN|HGNC=13114|UniProtKB=Q96MX3 Q96MX3 ZNF48 PTHR24376:SF239 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 48 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HUMAN|HGNC=18250|UniProtKB=Q8WUB8 Q8WUB8 PHF10 PTHR10615:SF174 HISTONE ACETYLTRANSFERASE PHD FINGER PROTEIN 10 histone modifying activity#GO:0140993;protein N-acyltransferase activity#GO:0140186;transcription regulator activity#GO:0140110;acetyltransferase activity#GO:0016407;binding#GO:0005488;protein N-acetyltransferase activity#GO:0034212;transferase activity#GO:0016740;histone acetyltransferase activity#GO:0004402;N-acetyltransferase activity#GO:0008080;chromatin binding#GO:0003682;acyltransferase activity#GO:0016746;protein-lysine-acetyltransferase activity#GO:0061733;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity, acting on a protein#GO:0140096;transcription coregulator activity#GO:0003712;catalytic activity#GO:0003824 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229 chromatin/chromatin-binding, or -regulatory protein#PC00077;histone modifying enzyme#PC00261 HUMAN|HGNC=6923|UniProtKB=Q9NR56 Q9NR56 MBNL1 PTHR12675:SF7 MUSCLEBLIND-LIKE PROTEIN MUSCLEBLIND-LIKE PROTEIN 1 nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 RNA splicing factor#PC00148;RNA processing factor#PC00147 HUMAN|HGNC=26137|UniProtKB=Q6NT76 Q6NT76 HMBOX1 PTHR14618:SF0 HOMEODOX-CONTAINING PROTEIN 1 HMBOX1 HOMEOBOX-CONTAINING PROTEIN 1 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=18340|UniProtKB=Q8NEZ3 Q8NEZ3 WDR19 PTHR14920:SF2 OSMOTIC AVOIDANCE ABNORMAL PROTEIN 1/WD REPEAT MEMBRANE PROTEIN WD REPEAT-CONTAINING PROTEIN 19 cellular process#GO:0009987;cell projection assembly#GO:0030031;establishment of localization in cell#GO:0051649;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton-dependent intracellular transport#GO:0030705;cellular component assembly#GO:0022607;transport#GO:0006810;intracellular transport#GO:0046907;plasma membrane bounded cell projection assembly#GO:0120031;microtubule-based process#GO:0007017;transport along microtubule#GO:0010970;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;cilium assembly#GO:0060271;cellular component organization#GO:0016043;intraciliary transport#GO:0042073;microtubule-based movement#GO:0007018;intraciliary retrograde transport#GO:0035721;cell projection organization#GO:0030030;microtubule-based transport#GO:0099111;organelle assembly#GO:0070925;cilium organization#GO:0044782;cellular localization#GO:0051641;localization#GO:0051179 cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cilium#GO:0005929;intraciliary transport particle#GO:0030990;membrane-bounded organelle#GO:0043227;intraciliary transport particle A#GO:0030991 HUMAN|HGNC=7455|UniProtKB=P03886 P03886 MT-ND1 PTHR11432:SF23 NADH DEHYDROGENASE SUBUNIT 1 NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 1 oxidoreductase activity, acting on NAD(P)H#GO:0016651;oxidoreductase activity#GO:0016491;NADH dehydrogenase activity#GO:0003954;catalytic activity#GO:0003824 metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091;cellular process#GO:0009987;cellular respiration#GO:0045333;energy derivation by oxidation of organic compounds#GO:0015980;aerobic respiration#GO:0009060 respiratory chain complex#GO:0098803;membrane protein complex#GO:0098796;membrane#GO:0016020;oxidoreductase complex#GO:1990204;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494;respiratory chain complex I#GO:0045271;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351 oxidoreductase#PC00176;dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=20599|UniProtKB=Q8WWU7 Q8WWU7 ITLN2 PTHR16146:SF21 INTELECTIN INTELECTIN-2 oligosaccharide binding#GO:0070492;binding#GO:0005488;carbohydrate binding#GO:0030246 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=3708|UniProtKB=O43915 O43915 VEGFD PTHR12025:SF11 VASCULAR ENDOTHELIAL GROWTH FACTOR VASCULAR ENDOTHELIAL GROWTH FACTOR D signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;signaling receptor regulator activity#GO:0030545;growth factor receptor binding#GO:0070851;growth factor activity#GO:0008083;receptor ligand activity#GO:0048018;protein binding#GO:0005515;molecular function activator activity#GO:0140677;signaling receptor binding#GO:0005102;binding#GO:0005488;cytokine receptor binding#GO:0005126 anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;blood vessel morphogenesis#GO:0048514;response to abiotic stimulus#GO:0009628;regulation of chemotaxis#GO:0050920;vascular endothelial growth factor receptor signaling pathway#GO:0048010;response to endogenous stimulus#GO:0009719;positive regulation of cell motility#GO:2000147;signaling#GO:0023052;circulatory system development#GO:0072359;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;animal gross anatomical part developmental process#GO:0160108;sprouting angiogenesis#GO:0002040;cellular response to growth factor stimulus#GO:0071363;angiogenesis#GO:0001525;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;response to stress#GO:0006950;positive regulation of immune system process#GO:0002684;regulation of response to external stimulus#GO:0032101;cell surface receptor signaling pathway#GO:0007166;anatomical structure formation involved in morphogenesis#GO:0048646;vasculature development#GO:0001944;positive regulation of response to external stimulus#GO:0032103;multicellular organism development#GO:0007275;cellular response to stimulus#GO:0051716;blood vessel development#GO:0001568;tube morphogenesis#GO:0035239;response to decreased oxygen levels#GO:0036293;response to oxygen levels#GO:0070482;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of leukocyte migration#GO:0002685;response to growth factor#GO:0070848;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;system development#GO:0048731;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of chemotaxis#GO:0050921;anatomical structure development#GO:0048856;regulation of cell motility#GO:2000145;cell communication#GO:0007154;positive regulation of cell migration#GO:0030335;positive regulation of cellular process#GO:0048522;regulation of locomotion#GO:0040012;tube development#GO:0035295;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;positive regulation of response to stimulus#GO:0048584;regulation of response to stimulus#GO:0048583;developmental process#GO:0032502;regulation of cell migration#GO:0030334;positive regulation of locomotion#GO:0040017;response to hypoxia#GO:0001666 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207;growth factor#PC00112 HUMAN|HGNC=29233|UniProtKB=Q7Z434 Q7Z434 MAVS PTHR21446:SF6 DUF3504 DOMAIN-CONTAINING PROTEIN MITOCHONDRIAL ANTIVIRAL-SIGNALING PROTEIN HUMAN|HGNC=33455|UniProtKB=A6NIM6 A6NIM6 SLC15A5 PTHR11654:SF91 OLIGOPEPTIDE TRANSPORTER-RELATED SOLUTE CARRIER FAMILY 15 MEMBER 5 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;cellular process#GO:0009987;transport#GO:0006810 membrane#GO:0016020;cellular anatomical structure#GO:0110165 transporter#PC00227 HUMAN|HGNC=983|UniProtKB=P06276 P06276 BCHE PTHR43918:SF5 ACETYLCHOLINESTERASE CHOLINESTERASE hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;carboxylic ester hydrolase activity#GO:0052689 cellular process#GO:0009987;metabolic process#GO:0008152;catabolic process#GO:0009056 membrane#GO:0016020;extracellular region#GO:0005576;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 esterase#PC00097 Nicotinic acetylcholine receptor signaling pathway#P00044>AChE#P01093;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>AChE#P01080;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>AChE#P01067 HUMAN|HGNC=6732|UniProtKB=O95944 O95944 NCR2 PTHR16423:SF7 TREM-LIKE TRANSCRIPT PROTEIN NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 2 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cell surface#GO:0009986;cellular anatomical structure#GO:0110165 HUMAN|HGNC=24376|UniProtKB=Q6BCY4 Q6BCY4 CYB5R2 PTHR19370:SF108 NADH-CYTOCHROME B5 REDUCTASE NADH-CYTOCHROME B5 REDUCTASE 2 anion binding#GO:0043168;binding#GO:0005488;flavin adenine dinucleotide binding#GO:0050660;small molecule binding#GO:0036094;nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167;oxidoreductase activity, acting on NAD(P)H#GO:0016651;catalytic activity#GO:0003824;nucleotide binding#GO:0000166;oxidoreductase activity#GO:0016491;heterocyclic compound binding#GO:1901363 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;reductase#PC00198 HUMAN|HGNC=6350|UniProtKB=O75840 O75840 KLF7 PTHR23235:SF77 KRUEPPEL-LIKE TRANSCRIPTION FACTOR KRUEPPEL-LIKE FACTOR 7 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=11430|UniProtKB=Q86Y82 Q86Y82 STX12 PTHR19957:SF88 SYNTAXIN SYNTAXIN-12 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;SNAP receptor activity#GO:0005484 metabolic process#GO:0008152;intracellular protein transport#GO:0006886;cellular component organization or biogenesis#GO:0071840;vesicle organization#GO:0016050;autophagosome assembly#GO:0000045;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;autophagy#GO:0006914;cellular process#GO:0009987;autophagosome organization#GO:1905037;organelle fusion#GO:0048284;cellular component assembly#GO:0022607;vesicle-mediated transport#GO:0016192;organelle membrane fusion#GO:0090174;cellular localization#GO:0051641;process utilizing autophagic mechanism#GO:0061919;protein transport#GO:0015031;cellular component organization#GO:0016043;intracellular transport#GO:0046907;transport#GO:0006810;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;membrane fusion#GO:0061025;membrane organization#GO:0061024;macroautophagy#GO:0016236;organelle assembly#GO:0070925;localization#GO:0051179;vacuole organization#GO:0007033;catabolic process#GO:0009056;vesicle fusion#GO:0006906 exocytic vesicle#GO:0070382;endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;synaptic vesicle#GO:0008021;vesicle#GO:0031982;synaptic vesicle membrane#GO:0030672;postsynapse#GO:0098794;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;synapse#GO:0045202;cellular anatomical structure#GO:0110165;SNARE complex#GO:0031201;organelle#GO:0043226;recycling endosome#GO:0055037;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;cell junction#GO:0030054;presynapse#GO:0098793;secretory vesicle#GO:0099503;membrane#GO:0016020;vesicle membrane#GO:0012506;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;transport vesicle membrane#GO:0030658;transport vesicle#GO:0030133 SNARE protein#PC00034 Adrenaline and noradrenaline biosynthesis#P00001>SNARE#P00072;Parkinson disease#P00049>Syntaxin#P01215 HUMAN|HGNC=9588|UniProtKB=P60484 P60484 PTEN PTHR12305:SF102 PHOSPHATASE WITH HOMOLOGY TO TENSIN PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN protein tyrosine phosphatase activity#GO:0004725;hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791 regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regulation of response to stimulus#GO:0048583;developmental process#GO:0032502;vasculature development#GO:0001944;multicellular organism development#GO:0007275;blood vessel development#GO:0001568;regulation of biological process#GO:0050789;regulation of cell communication#GO:0010646;regulation of cell cycle#GO:0051726;regulation of cellular process#GO:0050794;circulatory system development#GO:0072359;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051896;anatomical structure development#GO:0048856 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;membrane#GO:0016020;cell periphery#GO:0071944;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cell projection#GO:0042995;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 protein modifying enzyme#PC00260;protein phosphatase#PC00195 PI3 kinase pathway#P00048>PTEN#P01189;p53 pathway#P00059>PTEN#P01480;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>PTEN#G04675;p53 pathway feedback loops 2#P04398>PTEN#P04658;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>PTEN#P00905;p53 pathway feedback loops 2#P04398>PTEN#G04714;CCKR signaling map#P06959>PTEN#P07071;Hypoxia response via HIF activation#P00030>PTEN#P00824;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PTEN#P00849;p53 pathway#P00059>PTEN#G01579 HUMAN|HGNC=6897|UniProtKB=P27448 P27448 MARK3 PTHR24346:SF1 MAP/MICROTUBULE AFFINITY-REGULATING KINASE MAP_MICROTUBULE AFFINITY-REGULATING KINASE 3 protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=8647|UniProtKB=Q15365 Q15365 PCBP1 PTHR10288:SF96 KH DOMAIN CONTAINING RNA BINDING PROTEIN POLY(RC)-BINDING PROTEIN 1 single-stranded DNA binding#GO:0003697;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723;DNA binding#GO:0003677 positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252 organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031 HUMAN|HGNC=37147|UniProtKB=A6NI03 A6NI03 TRIM64B PTHR24103:SF716 E3 UBIQUITIN-PROTEIN LIGASE TRIM TRIPARTITE MOTIF-CONTAINING PROTEIN 64-RELATED ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824 innate immune response#GO:0045087;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;defense response#GO:0006952;response to external stimulus#GO:0009605;defense response to other organism#GO:0098542;response to other organism#GO:0051707;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;response to stress#GO:0006950;regulation of macromolecule biosynthetic process#GO:0010556;response to biotic stimulus#GO:0009607;immune response#GO:0006955;defense response to symbiont#GO:0140546;immune system process#GO:0002376;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=37268|UniProtKB=A6NHZ5 A6NHZ5 LRRC14B PTHR14224:SF27 SIMILAR TO PREFERENTIALLY EXPRESSED ANTIGEN IN MELANOMA-LIKE 3 LEUCINE-RICH REPEAT-CONTAINING PROTEIN 14B HUMAN|HGNC=9514|UniProtKB=P11464 P11464 PSG1 PTHR44427:SF16 CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 19 PREGNANCY-SPECIFIC BETA-1-GLYCOPROTEIN 1 cell adhesion molecule#PC00069 HUMAN|HGNC=1930|UniProtKB=P05060 P05060 CHGB PTHR10583:SF4 CHROMOGRANIN SECRETOGRANIN-1 vesicle#GO:0031982;intracellular vesicle#GO:0097708;secretory vesicle#GO:0099503;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;extracellular region#GO:0005576;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=23395|UniProtKB=Q9H2J1 Q9H2J1 ARRDC1-AS1 PTHR12138:SF150 PRIMATE-EXPANDED PROTEIN FAMILY CHROMOSOME 9 OPEN READING FRAME 37 HUMAN|HGNC=9900|UniProtKB=P98179 P98179 RBM3 PTHR48034:SF12 TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED RNA-BINDING PROTEIN 3 ribosomal large subunit binding#GO:0043023;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723;ribonucleoprotein complex binding#GO:0043021;ribosome binding#GO:0043022;protein-containing complex binding#GO:0044877 RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;cellular process#GO:0009987;regulation of protein metabolic process#GO:0051246;mRNA processing#GO:0006397;RNA processing#GO:0006396;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;regulation of biological process#GO:0050789;mRNA splicing, via spliceosome#GO:0000398;mRNA metabolic process#GO:0016071;post-transcriptional regulation of gene expression#GO:0010608;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA splicing, via transesterification reactions#GO:0000375;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255 nucleus#GO:0005634;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513 RNA metabolism protein#PC00031 HUMAN|HGNC=11952|UniProtKB=Q05952 Q05952 TNP2 PTHR17488:SF0 NUCLEAR TRANSITION PROTEIN 2 NUCLEAR TRANSITION PROTEIN 2 multicellular organismal reproductive process#GO:0048609;developmental process#GO:0032502;spermatogenesis#GO:0007283;sexual reproduction#GO:0019953;multicellular organismal process#GO:0032501;gamete generation#GO:0007276;male gamete generation#GO:0048232;reproductive process#GO:0022414;fertilization#GO:0009566;single fertilization#GO:0007338;developmental process involved in reproduction#GO:0003006;acrosome reaction#GO:0007340;multi-multicellular organism process#GO:0044706 protein-DNA complex#GO:0032993;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;nucleosome#GO:0000786;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;chromatin#GO:0000785;nucleus#GO:0005634;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=11820|UniProtKB=P01033 P01033 TIMP1 PTHR11844:SF20 METALLOPROTEASE INHIBITOR METALLOPROTEINASE INHIBITOR 1 enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414;peptidase regulator activity#GO:0061134;endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772;enzyme inhibitor activity#GO:0004857 biological regulation#GO:0065007;response to cytokine#GO:0034097;negative regulation of protein catabolic process#GO:0042177;response to chemical#GO:0042221;negative regulation of macromolecule metabolic process#GO:0010605;response to hormone#GO:0009725;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;regulation of primary metabolic process#GO:0080090;regulation of catabolic process#GO:0009894;regulation of proteolysis#GO:0030162;negative regulation of cellular process#GO:0048523;negative regulation of protein metabolic process#GO:0051248;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;response to endogenous stimulus#GO:0009719;response to peptide#GO:1901652;regulation of protein catabolic process#GO:0042176;negative regulation of catabolic process#GO:0009895 extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical structure#GO:0110165 protease inhibitor#PC00191;protein-binding activity modulator#PC00095 HUMAN|HGNC=34187|UniProtKB=Q9H1X3 Q9H1X3 DNAJC25 PTHR44176:SF1 DNAJ HOMOLOG SUBFAMILY C MEMBER 25 DNAJ HOMOLOG SUBFAMILY C MEMBER 25 protein folding#GO:0006457;biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152 membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HUMAN|HGNC=25565|UniProtKB=Q9NSG2 Q9NSG2 FIRRM PTHR16071:SF2 CHROMOSOME 1 OPEN READING FRAME 112 FIGNL1-INTERACTING REGULATOR OF RECOMBINATION AND MITOSIS HUMAN|HGNC=11355|UniProtKB=Q8N3U4 Q8N3U4 STAG2 PTHR11199:SF3 STROMAL ANTIGEN COHESIN SUBUNIT SA-2 chromatin binding#GO:0003682;binding#GO:0005488 cellular process#GO:0009987;cell cycle process#GO:0022402;organelle organization#GO:0006996;cell cycle#GO:0007049;cellular component organization#GO:0016043;chromosome organization#GO:0051276;cellular component organization or biogenesis#GO:0071840;sister chromatid cohesion#GO:0007062 intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cohesin complex#GO:0008278;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=1971|UniProtKB=Q7LGC8 Q7LGC8 CHST3 PTHR10704:SF60 CARBOHYDRATE SULFOTRANSFERASE CARBOHYDRATE SULFOTRANSFERASE 3 transferase activity, transferring sulphur-containing groups#GO:0016782;sulfotransferase activity#GO:0008146;catalytic activity#GO:0003824;transferase activity#GO:0016740 primary metabolic process#GO:0044238;amino sugar metabolic process#GO:0006040;protein metabolic process#GO:0019538;cellular process#GO:0009987;chondroitin sulfate proteoglycan metabolic process#GO:0050654;protein O-linked glycosylation#GO:0006493;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;sulfur compound metabolic process#GO:0006790;glycoprotein biosynthetic process#GO:0009101;chondroitin sulfate proteoglycan biosynthetic process#GO:0050650;biosynthetic process#GO:0009058;proteoglycan biosynthetic process#GO:0030166;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;proteoglycan metabolic process#GO:0006029;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170 transferase#PC00220;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=26260|UniProtKB=Q8N614 Q8N614 TMEM156 PTHR14788:SF5 TRANSMEMBRANE PROTEIN 156 TRANSMEMBRANE PROTEIN 156 HUMAN|HGNC=9261|UniProtKB=Q13356 Q13356 PPIL2 PTHR45625:SF1 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED RING-TYPE E3 UBIQUITIN-PROTEIN LIGASE PPIL2 transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;isomerase activity#GO:0016853;peptidyl-prolyl cis-trans isomerase activity#GO:0003755;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;cis-trans isomerase activity#GO:0016859 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;spliceosomal complex#GO:0005681;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;catalytic step 2 spliceosome#GO:0071013;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904 chaperone#PC00072 HUMAN|HGNC=31911|UniProtKB=Q8IZJ4 Q8IZJ4 RGL4 PTHR23113:SF223 GUANINE NUCLEOTIDE EXCHANGE FACTOR RAL-GDS-RELATED PROTEIN molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;guanyl-nucleotide exchange factor activity#GO:0005085 Ras protein signal transduction#GO:0007265;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=11030|UniProtKB=Q9Y6R1 Q9Y6R1 SLC4A4 PTHR11453:SF10 ANION EXCHANGE PROTEIN ELECTROGENIC SODIUM BICARBONATE COTRANSPORTER 1 solute:sodium symporter activity#GO:0015370;monoatomic cation transmembrane transporter activity#GO:0008324;symporter activity#GO:0015293;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;active transmembrane transporter activity#GO:0022804;bicarbonate transmembrane transporter activity#GO:0015106;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;secondary active transmembrane transporter activity#GO:0015291 intracellular monoatomic ion homeostasis#GO:0006873;homeostatic process#GO:0042592;regulation of intracellular pH#GO:0051453;regulation of pH#GO:0006885;regulation of biological quality#GO:0065008;transmembrane transport#GO:0055085;localization#GO:0051179;cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801;biological regulation#GO:0065007;transport#GO:0006810;chemical homeostasis#GO:0048878;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;establishment of localization#GO:0051234 cell periphery#GO:0071944;basal plasma membrane#GO:0009925;membrane#GO:0016020;basal part of cell#GO:0045178;basolateral plasma membrane#GO:0016323;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590 secondary carrier transporter#PC00258 HUMAN|HGNC=5857|UniProtKB=P0DOY3 P0DOY3 IGLC3 PTHR23266:SF283 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN LAMBDA CONSTANT 2-RELATED antigen binding#GO:0003823;binding#GO:0005488 immune system process#GO:0002376;immune effector process#GO:0002252;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;immune response#GO:0006955;response to stimulus#GO:0050896;adaptive immune response#GO:0002250 protein-containing complex#GO:0032991 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=15772|UniProtKB=Q9Y6D6 Q9Y6D6 ARFGEF1 PTHR10663:SF137 GUANYL-NUCLEOTIDE EXCHANGE FACTOR BREFELDIN A-INHIBITED GUANINE NUCLEOTIDE-EXCHANGE PROTEIN 1 cellular component organization or biogenesis#GO:0071840;endomembrane system organization#GO:0010256;organelle organization#GO:0006996;cellular component organization#GO:0016043;Golgi organization#GO:0007030;cellular process#GO:0009987 membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;Golgi apparatus subcompartment#GO:0098791 guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=2590|UniProtKB=P05108 P05108 CYP11A1 PTHR24279:SF3 CYTOCHROME P450 CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME, MITOCHONDRIAL oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;steroid hydroxylase activity#GO:0008395;catalytic activity#GO:0003824;monooxygenase activity#GO:0004497 cellular response to peptide hormone stimulus#GO:0071375;hormone biosynthetic process#GO:0042446;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;response to nitrogen compound#GO:1901698;lipid biosynthetic process#GO:0008610;cellular response to nitrogen compound#GO:1901699;hormone metabolic process#GO:0042445;response to peptide hormone#GO:0043434;biological regulation#GO:0065007;biosynthetic process#GO:0009058;steroid biosynthetic process#GO:0006694;sterol metabolic process#GO:0016125;lipid metabolic process#GO:0006629;cholesterol metabolic process#GO:0008203;cellular response to hormone stimulus#GO:0032870;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;small molecule metabolic process#GO:0044281;secondary alcohol metabolic process#GO:1902652;ketone metabolic process#GO:0042180;response to endogenous stimulus#GO:0009719;regulation of hormone levels#GO:0010817;regulation of biological quality#GO:0065008;olefinic compound metabolic process#GO:0120254;cellular response to chemical stimulus#GO:0070887;response to oxygen-containing compound#GO:1901700;response to chemical#GO:0042221;steroid metabolic process#GO:0008202;response to hormone#GO:0009725;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;alcohol metabolic process#GO:0006066;metabolic process#GO:0008152 organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966 HUMAN|HGNC=20255|UniProtKB=Q9UHJ3 Q9UHJ3 SFMBT1 PTHR12247:SF77 POLYCOMB GROUP PROTEIN SCM-LIKE WITH FOUR MBT DOMAINS PROTEIN 1 binding#GO:0005488;histone binding#GO:0042393;chromatin binding#GO:0003682;protein binding#GO:0005515 regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=20175|UniProtKB=Q9Y3E0 Q9Y3E0 GOLT1B PTHR21493:SF79 CGI-141-RELATED/LIPASE CONTAINING PROTEIN VESICLE TRANSPORT PROTEIN GOT1B membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020 metabolite interconversion enzyme#PC00262;lipase#PC00143;hydrolase#PC00121 HUMAN|HGNC=13595|UniProtKB=O75426 O75426 FBXO24 PTHR47004:SF1 F-BOX ONLY PROTEIN 24 F-BOX ONLY PROTEIN 24 HUMAN|HGNC=32942|UniProtKB=Q9HB31 Q9HB31 SEBOX PTHR47777:SF1 HOMEOBOX PROTEIN SEBOX HOMEOBOX PROTEIN SEBOX helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=30550|UniProtKB=O60337 O60337 MARCHF6 PTHR13145:SF0 SSM4 PROTEIN E3 UBIQUITIN-PROTEIN LIGASE MARCHF6 catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630 response to endoplasmic reticulum stress#GO:0034976;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;protein metabolic process#GO:0019538;ERAD pathway#GO:0036503;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;response to stimulus#GO:0050896;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;response to stress#GO:0006950;cellular process#GO:0009987;response to chemical#GO:0042221;proteasomal protein catabolic process#GO:0010498 endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=10072|UniProtKB=Q9UDY6 Q9UDY6 TRIM10 PTHR24103:SF708 E3 UBIQUITIN-PROTEIN LIGASE TRIM TRIPARTITE MOTIF-CONTAINING PROTEIN 10 catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787 response to biotic stimulus#GO:0009607;response to stress#GO:0006950;defense response to symbiont#GO:0140546;immune response#GO:0006955;response to stimulus#GO:0050896;defense response to other organism#GO:0098542;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to other organism#GO:0051707;immune system process#GO:0002376;innate immune response#GO:0045087;response to external stimulus#GO:0009605;defense response#GO:0006952 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=23421|UniProtKB=Q8TCA0 Q8TCA0 LRRC20 PTHR16083:SF87 LEUCINE RICH REPEAT CONTAINING PROTEIN LEUCINE-RICH REPEAT-CONTAINING PROTEIN 20 scaffold/adaptor protein#PC00226 HUMAN|HGNC=30943|UniProtKB=O00488 O00488 ZNF593 PTHR46095:SF1 ZINC FINGER PROTEIN 593 ZINC FINGER PROTEIN 593 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244;DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=25422|UniProtKB=Q4VNC1 Q4VNC1 ATP13A4 PTHR45630:SF1 CATION-TRANSPORTING ATPASE-RELATED CATION-TRANSPORTING ATPASE 13A4-RELATED transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;polyamine transmembrane transporter activity#GO:0015203 nitrogen compound transport#GO:0071705;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;transport#GO:0006810;establishment of localization#GO:0051234;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;intracellular monoatomic ion homeostasis#GO:0006873;homeostatic process#GO:0042592;calcium ion homeostasis#GO:0055074;inorganic ion homeostasis#GO:0098771;transmembrane transport#GO:0055085;localization#GO:0051179 late endosome membrane#GO:0031902;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;membrane#GO:0016020;endomembrane system#GO:0012505;late endosome#GO:0005770;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endosome#GO:0005768;endosome membrane#GO:0010008;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 primary active transporter#PC00068 HUMAN|HGNC=26963|UniProtKB=Q96FF7 Q96FF7 MISP3 PTHR18839:SF4 MITOTIC INTERACTOR AND SUBSTRATE OF PLK1 MISP FAMILY MEMBER MISP FAMILY MEMBER 3 HUMAN|HGNC=4851|UniProtKB=P42858 P42858 HTT PTHR10170:SF10 HUNTINGTON DISEASE PROTEIN HUNTINGTIN regulation of biological process#GO:0050789;establishment of organelle localization#GO:0051656;cell differentiation#GO:0030154;central nervous system development#GO:0007417;regulation of signaling#GO:0023051;microtubule-based transport#GO:0099111;regulation of intracellular signal transduction#GO:1902531;animal gross anatomical part developmental process#GO:0160108;cellular localization#GO:0051641;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;synaptic vesicle transport#GO:0048489;organelle transport along microtubule#GO:0072384;nervous system development#GO:0007399;establishment of vesicle localization#GO:0051650;synaptic vesicle localization#GO:0097479;microtubule-based process#GO:0007017;multicellular organism development#GO:0007275;regulation of cell communication#GO:0010646;regulation of calcium-mediated signaling#GO:0050848;regulation of cellular process#GO:0050794;microtubule-based movement#GO:0007018;organelle localization#GO:0051640;system development#GO:0048731;anatomical structure development#GO:0048856;localization#GO:0051179;vesicle localization#GO:0051648;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;cytoskeleton-dependent intracellular transport#GO:0030705;regulation of response to stimulus#GO:0048583;transport#GO:0006810;developmental process#GO:0032502;intracellular transport#GO:0046907;vesicle transport along microtubule#GO:0047496;neurogenesis#GO:0022008;vesicle cytoskeletal trafficking#GO:0099518;establishment of localization#GO:0051234;cellular developmental process#GO:0048869;transport along microtubule#GO:0010970 neuron projection#GO:0043005;cytoplasm#GO:0005737;somatodendritic compartment#GO:0036477;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;cell projection#GO:0042995;dendrite#GO:0030425;dendritic tree#GO:0097447;intracellular organelle#GO:0043229;axon#GO:0030424;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227 Huntington disease#P00029>Htt#P00766;Huntington disease#P00029>PolyQ Htt#P00800;Huntington disease#P00029>PolyQ HTT#G01532;Huntington disease#P00029>Truncated Htt#P00761;Huntington disease#P00029>HTT#G01530 HUMAN|HGNC=17601|UniProtKB=Q8N126 Q8N126 CADM3 PTHR45889:SF5 IG-LIKE DOMAIN-CONTAINING PROTEIN CELL ADHESION MOLECULE 3 cellular process#GO:0009987;cell adhesion#GO:0007155;cell-cell adhesion#GO:0098609;homophilic cell-cell adhesion#GO:0007156 synaptic membrane#GO:0097060;cell junction#GO:0030054;membrane#GO:0016020;cell periphery#GO:0071944;presynapse#GO:0098793;synapse#GO:0045202;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;presynaptic membrane#GO:0042734;plasma membrane#GO:0005886 HUMAN|HGNC=29252|UniProtKB=Q9P2K6 Q9P2K6 KLHL42 PTHR45972:SF2 BTB_2 DOMAIN-CONTAINING PROTEIN KELCH-LIKE PROTEIN 42 cellular process#GO:0009987;protein ubiquitination#GO:0016567;biological regulation#GO:0065007;post-translational protein modification#GO:0043687;proteasomal protein catabolic process#GO:0010498;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;regulation of biological process#GO:0050789;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;protein modification by small protein conjugation or removal#GO:0070647;regulation of microtubule-based process#GO:0032886;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538 transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;Cul3-RING ubiquitin ligase complex#GO:0031463 HUMAN|HGNC=11751|UniProtKB=Q14188 Q14188 TFDP2 PTHR12548:SF5 TRANSCRIPTION FACTOR DP TRANSCRIPTION FACTOR DP-2 binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=10602|UniProtKB=P51170 P51170 SCNN1G PTHR11690:SF19 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED EPITHELIAL SODIUM CHANNEL SUBUNIT GAMMA sodium channel activity#GO:0005272;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267 monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;cellular process#GO:0009987;sodium ion transport#GO:0006814;sodium ion transmembrane transport#GO:0035725;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;transport#GO:0006810 sodium channel complex#GO:0034706;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;cation channel complex#GO:0034703;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane protein complex#GO:0098796;membrane#GO:0016020 transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=31406|UniProtKB=Q9Y2I8 Q9Y2I8 WDR37 PTHR19855:SF12 WD40 REPEAT PROTEIN 12, 37 WD REPEAT-CONTAINING PROTEIN 37 HUMAN|HGNC=4260|UniProtKB=P36269 P36269 GGT5 PTHR11686:SF19 GAMMA GLUTAMYL TRANSPEPTIDASE GLUTATHIONE HYDROLASE 5 PROENZYME catalytic activity#GO:0003824;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 cellular process#GO:0009987;sulfur compound metabolic process#GO:0006790;response to stress#GO:0006950;biosynthetic process#GO:0009058;icosanoid biosynthetic process#GO:0046456;lipid biosynthetic process#GO:0008610;icosanoid metabolic process#GO:0006690;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;defense response#GO:0006952;sulfur compound catabolic process#GO:0044273;carboxylic acid biosynthetic process#GO:0046394;modified amino acid metabolic process#GO:0006575;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;inflammatory response#GO:0006954;glutathione metabolic process#GO:0006749;oxoacid metabolic process#GO:0043436 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 protein modifying enzyme#PC00260;protease#PC00190 HUMAN|HGNC=24591|UniProtKB=Q6UXB4 Q6UXB4 CLEC4G PTHR22802:SF245 C-TYPE LECTIN SUPERFAMILY MEMBER C-TYPE LECTIN DOMAIN FAMILY 4 MEMBER G binding#GO:0005488;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;pattern recognition receptor activity#GO:0038187;carbohydrate binding#GO:0030246 immune system process#GO:0002376;immune response#GO:0006955;response to stimulus#GO:0050896 cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;plasma membrane#GO:0005886;membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944 membrane traffic protein#PC00150 HUMAN|HGNC=26413|UniProtKB=Q86V42 Q86V42 FAM124A PTHR14715:SF4 FAM124 DOMAIN-CONTAINING PROTEIN-RELATED PROTEIN FAM124A HUMAN|HGNC=3494|UniProtKB=P41161 P41161 ETV5 PTHR11849:SF160 ETS ETS TRANSLOCATION VARIANT 5 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110 regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of biological process#GO:0050789;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;developmental process#GO:0032502;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 winged helix/forkhead transcription factor#PC00246;DNA-binding transcription factor#PC00218 HUMAN|HGNC=7576|UniProtKB=P13533 P13533 MYH6 PTHR45615:SF69 MYOSIN HEAVY CHAIN, NON-MUSCLE MYOSIN-6 catalytic activity#GO:0003824;microfilament motor activity#GO:0000146;macromolecular conformation isomerase activity#GO:0120543;cytoskeletal protein binding#GO:0008092;cytoskeletal motor activity#GO:0003774;isomerase activity#GO:0016853;polypeptide conformation or assembly isomerase activity#GO:0120544;binding#GO:0005488;actin filament binding#GO:0051015;actin binding#GO:0003779;ATP-dependent activity#GO:0140657;protein binding#GO:0005515;protein-containing complex binding#GO:0044877 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;organelle#GO:0043226;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;actin cytoskeleton#GO:0015629;myosin complex#GO:0016459 actin or actin-binding cytoskeletal protein#PC00041 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Myosin#P00867;Cytoskeletal regulation by Rho GTPase#P00016>Myosin#P00522;Wnt signaling pathway#P00057>NFAT Target Genes#G01559 HUMAN|HGNC=3052|UniProtKB=P15924 P15924 DSP PTHR23169:SF26 ENVOPLAKIN DESMOPLAKIN cellular component organization#GO:0016043;response to stimulus#GO:0050896;intermediate filament cytoskeleton organization#GO:0045104;intermediate filament-based process#GO:0045103;animal gross anatomical part developmental process#GO:0160108;cell adhesion#GO:0007155;anatomical structure development#GO:0048856;wound healing#GO:0042060;organelle organization#GO:0006996;cell-cell adhesion#GO:0098609;response to stress#GO:0006950;response to wounding#GO:0009611;cellular process#GO:0009987;skin development#GO:0043588;cytoskeleton organization#GO:0007010;developmental process#GO:0032502;cellular component organization or biogenesis#GO:0071840;animal organ development#GO:0048513 intermediate filament#GO:0005882;cell-cell contact zone#GO:0044291;cell junction#GO:0030054;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;cell periphery#GO:0071944;cell-cell junction#GO:0005911;membrane#GO:0016020;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;intercalated disc#GO:0014704;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165 intermediate filament binding protein#PC00130;intermediate filament#PC00129 HUMAN|HGNC=5130|UniProtKB=P31274 P31274 HOXC9 PTHR45970:SF1 AGAP004664-PA HOMEOBOX PROTEIN HOX-C9 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488 regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;skeletal system development#GO:0001501;chordate embryonic development#GO:0043009;animal gross anatomical part developmental process#GO:0160108;embryo development#GO:0009790;embryonic morphogenesis#GO:0048598;multicellular organism development#GO:0007275;animal organ development#GO:0048513;anterior/posterior pattern specification#GO:0009952;regulation of macromolecule metabolic process#GO:0060255;animal organ morphogenesis#GO:0009887;regulation of cellular process#GO:0050794;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;pattern specification process#GO:0007389;embryonic organ development#GO:0048568;embryo development ending in birth or egg hatching#GO:0009792;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;regionalization#GO:0003002;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;skeletal system morphogenesis#GO:0048705;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 HUMAN|HGNC=750|UniProtKB=P46597 P46597 ASMT PTHR11746:SF362 O-METHYLTRANSFERASE ACETYLSEROTONIN O-METHYLTRANSFERASE catalytic activity#GO:0003824;transferase activity#GO:0016740;O-methyltransferase activity#GO:0008171;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757 regulation of biological quality#GO:0065008;methylation#GO:0032259;metabolic process#GO:0008152;biosynthetic process#GO:0009058;biological regulation#GO:0065007;hormone biosynthetic process#GO:0042446;hormone metabolic process#GO:0042445;cellular process#GO:0009987;indole-containing compound metabolic process#GO:0042430;regulation of hormone levels#GO:0010817 methyltransferase#PC00155 HUMAN|HGNC=39602|UniProtKB=B9A014 B9A014 C21orf140 PTHR35969:SF1 PROTEIN FAM243A-RELATED SIMILAR TO HUMAN CHROMOSOME 21 OPEN READING FRAME 140 HUMAN|HGNC=29566|UniProtKB=Q96GM1 Q96GM1 PLPPR2 PTHR10165:SF15 LIPID PHOSPHATE PHOSPHATASE PHOSPHOLIPID PHOSPHATASE-RELATED PROTEIN TYPE 2 phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824 biological regulation#GO:0065007;signal transduction#GO:0007165;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;lipid modification#GO:0030258;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;signaling#GO:0023052;phospholipid metabolic process#GO:0006644;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;phospholipid dephosphorylation#GO:0046839;cellular response to stimulus#GO:0051716;phosphate-containing compound metabolic process#GO:0006796;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;cell communication#GO:0007154;dephosphorylation#GO:0016311 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 hydrolase#PC00121;phosphatase#PC00181 HUMAN|HGNC=32404|UniProtKB=A6NM11 A6NM11 LRRC37A2 PTHR23045:SF9 LEUCINE-RICH REPEAT-CONTAINING PROTEIN 37A LEUCINE-RICH REPEAT-CONTAINING PROTEIN 37A-RELATED transmembrane signal receptor#PC00197 HUMAN|HGNC=25127|UniProtKB=Q8WVV9 Q8WVV9 HNRNPLL PTHR15592:SF13 MATRIN 3/NUCLEAR PROTEIN 220-RELATED HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN L-LIKE RNA processing factor#PC00147 HUMAN|HGNC=23795|UniProtKB=Q9BZ81 Q9BZ81 MAGEB5 PTHR11736:SF35 MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN MELANOMA-ASSOCIATED ANTIGEN B5 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 scaffold/adaptor protein#PC00226 HUMAN|HGNC=8665|UniProtKB=Q9Y5I1 Q9Y5I1 PCDHA11 PTHR24028:SF68 CADHERIN-87A PROTOCADHERIN ALPHA-11 cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 cell adhesion molecule#PC00069;cadherin#PC00057 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HUMAN|HGNC=23044|UniProtKB=Q8WY41 Q8WY41 NANOS1 PTHR12887:SF18 NANOS PROTEIN NANOS HOMOLOG 1 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729 cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;developmental process#GO:0032502;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;negative regulation of macromolecule metabolic process#GO:0010605;anatomical structure development#GO:0048856;multicellular organismal reproductive process#GO:0048609;sexual reproduction#GO:0019953;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of protein metabolic process#GO:0051248;reproductive process#GO:0022414;developmental process involved in reproduction#GO:0003006;germ cell development#GO:0007281;oogenesis#GO:0048477;regulation of protein metabolic process#GO:0051246;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;negative regulation of translation#GO:0017148;gamete generation#GO:0007276;cell differentiation#GO:0030154;cell development#GO:0048468;cellular process involved in reproduction in multicellular organism#GO:0022412;negative regulation of metabolic process#GO:0009892;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;perinuclear region of cytoplasm#GO:0048471 RNA metabolism protein#PC00031 HUMAN|HGNC=6160|UniProtKB=P18084 P18084 ITGB5 PTHR10082:SF26 INTEGRIN BETA SUBUNIT INTEGRIN BETA-5 signaling receptor binding#GO:0005102;binding#GO:0005488;cell adhesion molecule binding#GO:0050839;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;integrin binding#GO:0005178 biological regulation#GO:0065007;contractile actin filament bundle assembly#GO:0030038;cell migration#GO:0016477;actin filament organization#GO:0007015;cell adhesion mediated by integrin#GO:0033627;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;actin cytoskeleton organization#GO:0030036;cell motility#GO:0048870;regulation of cellular process#GO:0050794;response to growth factor#GO:0070848;cellular response to transforming growth factor beta stimulus#GO:0071560;cellular response to stimulus#GO:0051716;actin filament bundle assembly#GO:0051017;supramolecular fiber organization#GO:0097435;enzyme-linked receptor protein signaling pathway#GO:0007167;cell-substrate adhesion#GO:0031589;cell communication#GO:0007154;response to transforming growth factor beta#GO:0071559;actin filament-based process#GO:0030029;cytoskeleton organization#GO:0007010;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;cellular component assembly#GO:0022607;cellular process#GO:0009987;signal transduction#GO:0007165;cell-cell adhesion#GO:0098609;transforming growth factor beta receptor signaling pathway#GO:0007179;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular component organization or biogenesis#GO:0071840;cell surface receptor signaling pathway#GO:0007166;signaling#GO:0023052;actomyosin structure organization#GO:0031032;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;actin filament bundle organization#GO:0061572;regulation of biological process#GO:0050789;integrin-mediated signaling pathway#GO:0007229;cellular component organization#GO:0016043;response to endogenous stimulus#GO:0009719;cellular response to growth factor stimulus#GO:0071363;stress fiber assembly#GO:0043149;cell adhesion#GO:0007155;cell-matrix adhesion#GO:0007160 plasma membrane#GO:0005886;cell-substrate junction#GO:0030055;focal adhesion#GO:0005925;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cell surface#GO:0009986;cell periphery#GO:0071944;protein complex involved in cell adhesion#GO:0098636;plasma membrane protein complex#GO:0098797;membrane#GO:0016020;membrane protein complex#GO:0098796;anchoring junction#GO:0070161;integrin complex#GO:0008305;cell junction#GO:0030054;signaling receptor complex#GO:0043235 integrin#PC00126 Integrin signalling pathway#P00034>Integrin beta#P00931 HUMAN|HGNC=28387|UniProtKB=Q96KX0 Q96KX0 LYZL4 PTHR11407:SF21 LYSOZYME C LYSOZYME-LIKE PROTEIN 4 peptidoglycan muralytic activity#GO:0061783;catalytic activity#GO:0003824;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787;lysozyme activity#GO:0003796 single fertilization#GO:0007338;fusion of sperm to egg plasma membrane involved in single fertilization#GO:0007342;cellular process#GO:0009987;fertilization#GO:0009566;cellular process involved in reproduction in multicellular organism#GO:0022412;reproductive process#GO:0022414;sexual reproduction#GO:0019953;multicellular organismal reproductive process#GO:0048609 secretory vesicle#GO:0099503;cytoplasm#GO:0005737;sperm flagellum#GO:0036126;endomembrane system#GO:0012505;cilium#GO:0005929;intracellular organelle#GO:0043229;9+2 motile cilium#GO:0097729;acrosomal vesicle#GO:0001669;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;vesicle#GO:0031982;intracellular vesicle#GO:0097708;cell projection#GO:0042995;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;motile cilium#GO:0031514;organelle#GO:0043226;cellular anatomical structure#GO:0110165 glycosidase#PC00110 HUMAN|HGNC=10720|UniProtKB=P14151 P14151 SELL PTHR19325:SF543 COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING L-SELECTIN organic acid binding#GO:0043177;carboxylic acid binding#GO:0031406;binding#GO:0005488;anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167;carbohydrate binding#GO:0030246;carbohydrate derivative binding#GO:0097367;oligosaccharide binding#GO:0070492 cell migration#GO:0016477;cell motility#GO:0048870;response to cytokine#GO:0034097;response to chemical#GO:0042221;response to stimulus#GO:0050896;cell-cell adhesion#GO:0098609;cellular process#GO:0009987;heterophilic cell-cell adhesion#GO:0007157;leukocyte cell-cell adhesion#GO:0007159;response to peptide#GO:1901652;immune system process#GO:0002376;leukocyte migration#GO:0050900;cell adhesion#GO:0007155 side of membrane#GO:0098552;extracellular region#GO:0005576;external side of plasma membrane#GO:0009897;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 defense/immunity protein#PC00090;complement component#PC00078 HUMAN|HGNC=14654|UniProtKB=Q9HBI0 Q9HBI0 PARVG PTHR12114:SF1 PARVIN GAMMA-PARVIN protein binding#GO:0005515;binding#GO:0005488;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092 cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;substrate adhesion-dependent cell spreading#GO:0034446;regulation of anatomical structure morphogenesis#GO:0022603;cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;regulation of cell shape#GO:0008360;regulation of biological process#GO:0050789;actin cytoskeleton organization#GO:0030036;cell projection organization#GO:0030030;regulation of developmental process#GO:0050793;establishment or maintenance of cell polarity#GO:0007163;actin filament-based process#GO:0030029;cell adhesion#GO:0007155;cell-substrate adhesion#GO:0031589;regulation of biological quality#GO:0065008 cell-substrate junction#GO:0030055;intracellular membraneless organelle#GO:0043232;focal adhesion#GO:0005925;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;actin cytoskeleton#GO:0015629;anchoring junction#GO:0070161;intracellular anatomical structure#GO:0005622;cell junction#GO:0030054;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 actin or actin-binding cytoskeletal protein#PC00041;actin and actin related protein#PC00039 HUMAN|HGNC=13071|UniProtKB=Q9HBE1 Q9HBE1 PATZ1 PTHR24399:SF15 ZINC FINGER AND BTB DOMAIN-CONTAINING POZ-, AT HOOK-, AND ZINC FINGER-CONTAINING PROTEIN 1 sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription repressor activity#GO:0001217;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488 negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cytokine production#GO:0001817;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 DNA-binding transcription factor#PC00218;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=16142|UniProtKB=Q9H3Y8 Q9H3Y8 PPDPF PTHR14572:SF0 PANCREATIC PROGENITOR CELL DIFFERENTIATION AND PROLIFERATION FACTOR PANCREATIC PROGENITOR CELL DIFFERENTIATION AND PROLIFERATION FACTOR HUMAN|HGNC=7999|UniProtKB=P56975 P56975 NRG3 PTHR11100:SF18 HEREGULIN-NEUREGULIN FAMILY MEMBER PRO-NEUREGULIN-3, MEMBRANE-BOUND ISOFORM receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;binding#GO:0005488;signaling receptor binding#GO:0005102;protein binding#GO:0005515;molecular function activator activity#GO:0140677 biological regulation#GO:0065007;signal transduction#GO:0007165;ERBB signaling pathway#GO:0038127;cellular process#GO:0009987;animal organ development#GO:0048513;developmental process#GO:0032502;cell surface receptor signaling pathway#GO:0007166;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;intracellular signal transduction#GO:0035556;animal gross anatomical part developmental process#GO:0160108;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207;growth factor#PC00112 EGF receptor signaling pathway#P00018>EGF#P00549 HUMAN|HGNC=21345|UniProtKB=Q6ZW05 Q6ZW05 PTCHD4 PTHR10796:SF15 PATCHED-RELATED PATCHED DOMAIN-CONTAINING PROTEIN 4 membrane#GO:0016020;cellular anatomical structure#GO:0110165 protein-binding activity modulator#PC00095 HUMAN|HGNC=37218|UniProtKB=C9JDP6 C9JDP6 CLDN25 PTHR12002:SF87 CLAUDIN CLAUDIN-25 cellular component organization or biogenesis#GO:0071840;cell-cell junction assembly#GO:0007043;cell-cell junction organization#GO:0045216;cell junction organization#GO:0034330;cellular component assembly#GO:0022607;cellular process#GO:0009987;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;cell junction assembly#GO:0034329 apical junction complex#GO:0043296;anchoring junction#GO:0070161;tight junction#GO:0070160;cell junction#GO:0030054;cell periphery#GO:0071944;membrane#GO:0016020;cell-cell junction#GO:0005911;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;bicellular tight junction#GO:0005923 cell junction protein#PC00070;tight junction#PC00214 HUMAN|HGNC=7873|UniProtKB=P35228 P35228 NOS2 PTHR19384:SF56 NITRIC OXIDE SYNTHASE-RELATED NITRIC OXIDE SYNTHASE, INDUCIBLE catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen#GO:0016709;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;oxidoreductase activity#GO:0016491;nucleotide binding#GO:0000166;ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;carbohydrate derivative binding#GO:0097367;monooxygenase activity#GO:0004497;ribonucleotide binding#GO:0032553;heterocyclic compound binding#GO:1901363;nucleoside phosphate binding#GO:1901265;flavin adenine dinucleotide binding#GO:0050660;binding#GO:0005488;oxidoreductase activity, acting on NAD(P)H#GO:0016651 inflammatory response#GO:0006954;circulatory system process#GO:0003013;response to bacterium#GO:0009617;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;response to external biotic stimulus#GO:0043207;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;defense response#GO:0006952;response to external stimulus#GO:0009605;system process#GO:0003008;carboxylic acid catabolic process#GO:0046395;regulation of blood pressure#GO:0008217;amino acid metabolic process#GO:0006520;response to other organism#GO:0051707;biosynthetic process#GO:0009058;biological regulation#GO:0065007;proteinogenic amino acid metabolic process#GO:0170039;multicellular organismal process#GO:0032501;blood circulation#GO:0008015;response to oxygen-containing compound#GO:1901700;defense response to bacterium#GO:0042742;oxoacid metabolic process#GO:0043436;regulation of biological quality#GO:0065008;regulation of biological process#GO:0050789;response to molecule of bacterial origin#GO:0002237;carboxylic acid metabolic process#GO:0019752;response to endogenous stimulus#GO:0009719;small molecule catabolic process#GO:0044282;biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;metabolic process#GO:0008152;response to lipopolysaccharide#GO:0032496;cellular process#GO:0009987;signal transduction#GO:0007165;response to hormone#GO:0009725;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;arginine metabolic process#GO:0006525;intracellular signaling cassette#GO:0141124;response to lipid#GO:0033993;response to chemical#GO:0042221 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cell periphery#GO:0071944;nucleus#GO:0005634;membrane#GO:0016020;cytosol#GO:0005829 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 PI3 kinase pathway#P00048>NOS#P01205 HUMAN|HGNC=12681|UniProtKB=P49765 P49765 VEGFB PTHR12025:SF12 VASCULAR ENDOTHELIAL GROWTH FACTOR VASCULAR ENDOTHELIAL GROWTH FACTOR B protein binding#GO:0005515;molecular function activator activity#GO:0140677;binding#GO:0005488;signaling receptor binding#GO:0005102;cytokine receptor binding#GO:0005126;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;growth factor activity#GO:0008083;signaling receptor regulator activity#GO:0030545;growth factor receptor binding#GO:0070851;receptor ligand activity#GO:0048018 cell surface receptor signaling pathway#GO:0007166;anatomical structure formation involved in morphogenesis#GO:0048646;vasculature development#GO:0001944;multicellular organism development#GO:0007275;positive regulation of response to external stimulus#GO:0032103;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;response to stress#GO:0006950;positive regulation of immune system process#GO:0002684;regulation of response to external stimulus#GO:0032101;sprouting angiogenesis#GO:0002040;animal gross anatomical part developmental process#GO:0160108;cellular response to growth factor stimulus#GO:0071363;angiogenesis#GO:0001525;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;vascular endothelial growth factor receptor signaling pathway#GO:0048010;regulation of chemotaxis#GO:0050920;positive regulation of cell motility#GO:2000147;response to endogenous stimulus#GO:0009719;blood vessel morphogenesis#GO:0048514;response to abiotic stimulus#GO:0009628;signaling#GO:0023052;cellular response to endogenous stimulus#GO:0071495;circulatory system development#GO:0072359;response to stimulus#GO:0050896;developmental process#GO:0032502;regulation of cell migration#GO:0030334;regulation of response to stimulus#GO:0048583;positive regulation of locomotion#GO:0040017;response to hypoxia#GO:0001666;positive regulation of cellular process#GO:0048522;positive regulation of cell migration#GO:0030335;biological regulation#GO:0065007;tube development#GO:0035295;regulation of locomotion#GO:0040012;positive regulation of response to stimulus#GO:0048584;multicellular organismal process#GO:0032501;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;system development#GO:0048731;cell communication#GO:0007154;regulation of cell motility#GO:2000145;enzyme-linked receptor protein signaling pathway#GO:0007167;positive regulation of chemotaxis#GO:0050921;anatomical structure development#GO:0048856;cellular response to stimulus#GO:0051716;blood vessel development#GO:0001568;tube morphogenesis#GO:0035239;response to decreased oxygen levels#GO:0036293;response to oxygen levels#GO:0070482;response to growth factor#GO:0070848;regulation of leukocyte migration#GO:0002685;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 growth factor#PC00112;intercellular signal molecule#PC00207 HUMAN|HGNC=17167|UniProtKB=Q9BQS2 Q9BQS2 SYT15 PTHR10024:SF234 SYNAPTOTAGMIN SYNAPTOTAGMIN-15-RELATED protein binding#GO:0005515;molecular sensor activity#GO:0140299;molecular function regulator activity#GO:0098772;lipid binding#GO:0008289;phospholipid binding#GO:0005543;binding#GO:0005488;SNARE binding#GO:0000149 establishment of localization#GO:0051234;localization#GO:0051179;regulation of secretion#GO:0051046;regulation of exocytosis#GO:0017157;regulation of secretion by cell#GO:1903530;regulation of transport#GO:0051049;regulation of localization#GO:0032879;transport#GO:0006810;regulation of cellular process#GO:0050794;vesicle-mediated transport#GO:0016192;biological regulation#GO:0065007;cellular process#GO:0009987;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627 exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;secretory vesicle#GO:0099503;membrane#GO:0016020;cell periphery#GO:0071944;endomembrane system#GO:0012505;transport vesicle#GO:0030133;cytoplasm#GO:0005737;plasma membrane#GO:0005886 membrane trafficking regulatory protein#PC00151 Synaptic vesicle trafficking#P05734>Synaptotagmin#P05769 HUMAN|HGNC=3091|UniProtKB=Q13627 Q13627 DYRK1A PTHR24058:SF121 DUAL SPECIFICITY PROTEIN KINASE DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 1A transcription coregulator activity#GO:0003712;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transcription coactivator activity#GO:0003713;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;transcription regulator activity#GO:0140110;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 protein modifying enzyme#PC00260 HUMAN|HGNC=1113|UniProtKB=P32247 P32247 BRS3 PTHR45695:SF6 LEUCOKININ RECEPTOR-RELATED BOMBESIN RECEPTOR SUBTYPE-3 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888;neuropeptide receptor activity#GO:0008188 signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=5413|UniProtKB=Q01629 Q01629 IFITM2 PTHR13999:SF8 INTERFERON INDUCIBLE TRANSMEMBRANE PROTEIN INTERFERON-INDUCED TRANSMEMBRANE PROTEIN 2 regulation of cellular process#GO:0050794;response to external biotic stimulus#GO:0043207;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;response to virus#GO:0009615;cytokine-mediated signaling pathway#GO:0019221;biological regulation#GO:0065007;response to other organism#GO:0051707;immune response#GO:0006955;innate immune response#GO:0045087;response to external stimulus#GO:0009605;defense response#GO:0006952;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052;defense response to virus#GO:0051607;negative regulation of biological process#GO:0048519;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;response to peptide#GO:1901652;immune system process#GO:0002376;type I interferon-mediated signaling pathway#GO:0060337;response to cytokine#GO:0034097;response to chemical#GO:0042221;defense response to other organism#GO:0098542;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;signal transduction#GO:0007165;defense response to symbiont#GO:0140546;response to type II interferon#GO:0034341;cellular process#GO:0009987;cell surface receptor signaling pathway#GO:0007166 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 defense/immunity protein#PC00090 HUMAN|HGNC=26676|UniProtKB=Q5T655 Q5T655 CFAP58 PTHR32083:SF31 CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58-RELATED CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 58 intracellular membraneless organelle#GO:0043232;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 structural protein#PC00211 HUMAN|HGNC=6487|UniProtKB=P55268 P55268 LAMB2 PTHR10574:SF36 NETRIN/LAMININ-RELATED LAMININ SUBUNIT BETA-2 extracellular matrix structural constituent#GO:0005201;structural molecule activity#GO:0005198 cellular component assembly#GO:0022607;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;cellular component biogenesis#GO:0044085;neuron projection development#GO:0031175;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cell projection morphogenesis#GO:0048858;substrate adhesion-dependent cell spreading#GO:0034446;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell morphogenesis#GO:0000902;cell development#GO:0048468;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;neuron development#GO:0048666;axonogenesis#GO:0007409;animal gross anatomical part developmental process#GO:0160108;extracellular structure organization#GO:0043062;cell adhesion#GO:0007155;generation of neurons#GO:0048699;extracellular matrix assembly#GO:0085029;tissue development#GO:0009888;cell migration#GO:0016477;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;axon development#GO:0061564;axon guidance#GO:0007411;cellular developmental process#GO:0048869;neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;cell motility#GO:0048870;cell-substrate adhesion#GO:0031589;anatomical structure development#GO:0048856;extracellular matrix organization#GO:0030198;external encapsulating structure organization#GO:0045229;system development#GO:0048731 extracellular protein-containing complex#GO:0140392;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;basement membrane#GO:0005604;supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 extracellular matrix protein#PC00102 Integrin signalling pathway#P00034>Laminin#P00947 HUMAN|HGNC=12887|UniProtKB=Q9UII5 Q9UII5 ZNF107 PTHR24376:SF79 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 107 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=38|UniProtKB=O94911 O94911 ABCA8 PTHR19229:SF274 ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA ABC-TYPE ORGANIC ANION TRANSPORTER ABCA8 ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657;lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399 lipid localization#GO:0010876;macromolecule localization#GO:0033036;transport#GO:0006810;lipid transport#GO:0006869;localization#GO:0051179;establishment of localization#GO:0051234 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 ATP-binding cassette (ABC) transporter#PC00003 HUMAN|HGNC=23432|UniProtKB=Q9NXG0 Q9NXG0 CNTLN PTHR18957:SF0 CENTLEIN CENTLEIN microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;microtubule organizing center organization#GO:0031023;cellular component organization#GO:0016043;cell cycle#GO:0007049;organelle organization#GO:0006996;cellular process#GO:0009987;cell cycle process#GO:0022402;centrosome cycle#GO:0007098;cytoskeleton organization#GO:0007010 organelle#GO:0043226;cellular anatomical structure#GO:0110165;centriole#GO:0005814;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;microtubule organizing center#GO:0005815;centrosome#GO:0005813;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 HUMAN|HGNC=4650|UniProtKB=P29083 P29083 GTF2E1 PTHR13097:SF8 TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1 DNA-templated transcription initiation#GO:0006352;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;transcription initiation at RNA polymerase II promoter#GO:0006367;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;transcription by RNA polymerase II#GO:0006366 membrane-enclosed lumen#GO:0031974;RNA polymerase II transcription regulator complex#GO:0090575;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;protein-containing complex#GO:0032991;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;transcription regulator complex#GO:0005667;intracellular protein-containing complex#GO:0140535;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;RNA polymerase II, holoenzyme#GO:0016591;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428 RNA metabolism protein#PC00031;general transcription factor#PC00259 General transcription regulation#P00023>TFIIEalpha#P00669;General transcription regulation#P00023>TFIIE#P00666;Transcription regulation by bZIP transcription factor#P00055>TFIIEalpha#P01398;Transcription regulation by bZIP transcription factor#P00055>TFIIE#P01395 HUMAN|HGNC=7801|UniProtKB=Q96HA7 Q96HA7 TONSL PTHR46358:SF1 TONSOKU-LIKE PROTEIN TONSOKU-LIKE PROTEIN DNA-templated DNA replication#GO:0006261;recombinational repair#GO:0000725;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular response to stimulus#GO:0051716;DNA replication#GO:0006260;double-strand break repair via homologous recombination#GO:0000724;macromolecule metabolic process#GO:0043170;double-strand break repair#GO:0006302;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA damage response#GO:0006974;DNA recombination#GO:0006310;replication fork processing#GO:0031297;nucleobase-containing compound metabolic process#GO:0006139;response to stress#GO:0006950;cellular process#GO:0009987 intracellular organelle#GO:0043229;nuclear replication fork#GO:0043596;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;replication fork#GO:0005657;chromosome#GO:0005694;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;membraneless organelle#GO:0043228;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232 HUMAN|HGNC=4867|UniProtKB=Q15751 Q15751 HERC1 PTHR22870:SF155 REGULATOR OF CHROMOSOME CONDENSATION E3 UBIQUITIN-PROTEIN LIGASE HERC1-RELATED guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=28749|UniProtKB=Q86WX3 Q86WX3 RPS19BP1 PTHR31454:SF2 ACTIVE REGULATOR OF SIRT1 ACTIVE REGULATOR OF SIRT1 enzyme binding#GO:0019899;binding#GO:0005488;protein binding#GO:0005515 nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular organelle#GO:0043229;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 HUMAN|HGNC=30535|UniProtKB=Q8WVJ2 Q8WVJ2 NUDCD2 PTHR12356:SF18 NUCLEAR MOVEMENT PROTEIN NUDC NUDC DOMAIN-CONTAINING PROTEIN 2 metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;protein maturation#GO:0051604;protein folding#GO:0006457;biosynthetic process#GO:0009058 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 microtubule or microtubule-binding cytoskeletal protein#PC00157;cytoskeletal protein#PC00085 HUMAN|HGNC=2287|UniProtKB=P24310 P24310 COX7A1 PTHR10510:SF5 CYTOCHROME C OXIDASE POLYPEPTIDE 7A CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 cellular process#GO:0009987;generation of precursor metabolites and energy#GO:0006091;metabolic process#GO:0008152;aerobic respiration#GO:0009060;cellular respiration#GO:0045333;energy derivation by oxidation of organic compounds#GO:0015980;oxidative phosphorylation#GO:0006119 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;membrane#GO:0016020;mitochondrial membrane#GO:0031966;respiratory chain complex#GO:0098803;mitochondrion#GO:0005739;mitochondrial envelope#GO:0005740 oxidoreductase#PC00176;oxidase#PC00175 HUMAN|HGNC=4571|UniProtKB=P42261 P42261 GRIA1 PTHR18966:SF157 IONOTROPIC GLUTAMATE RECEPTOR GLUTAMATE RECEPTOR 1 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;dicarboxylic acid transmembrane transporter activity#GO:0005310;passive transmembrane transporter activity#GO:0022803;glutamate receptor activity#GO:0008066;ligand-gated channel activity#GO:0022834;transmembrane transporter activity#GO:0022857;molecular transducer activity#GO:0060089;channel activity#GO:0015267;carboxylic acid transmembrane transporter activity#GO:0046943;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic ion channel activity#GO:0005216;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion transmembrane transporter activity#GO:0015075;signaling receptor activity#GO:0038023;amino acid transmembrane transporter activity#GO:0015171;neurotransmitter receptor activity#GO:0030594;transporter activity#GO:0005215;gated channel activity#GO:0022836;transmembrane signaling receptor activity#GO:0004888 regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;modulation of chemical synaptic transmission#GO:0050804;signaling#GO:0023052;regulation of cell communication#GO:0010646;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;regulation of signaling#GO:0023051;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;cellular process#GO:0009987;synaptic signaling#GO:0099536;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;synaptic transmission, glutamatergic#GO:0035249;regulation of trans-synaptic signaling#GO:0099177 signaling receptor complex#GO:0043235;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;neuron to neuron synapse#GO:0098984;monoatomic ion channel complex#GO:0034702;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;postsynaptic density#GO:0014069;dendritic tree#GO:0097447;dendrite#GO:0030425;postsynaptic density membrane#GO:0098839;transmembrane transporter complex#GO:1902495;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;plasma membrane bounded cell projection#GO:0120025;asymmetric synapse#GO:0032279;synaptic membrane#GO:0097060;transporter complex#GO:1990351;cell junction#GO:0030054;neuron projection#GO:0043005;protein-containing complex#GO:0032991;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;dendritic spine#GO:0043197;postsynapse#GO:0098794;neuron spine#GO:0044309;cell projection#GO:0042995;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226 transmembrane signal receptor#PC00197 Ionotropic glutamate receptor pathway#P00037>Glu1#P01018;Metabotropic glutamate receptor group III pathway#P00039>A/K#P01046;Ionotropic glutamate receptor pathway#P00037>AMPA#P01019;Ionotropic glutamate receptor pathway#P00037>A/K#P01025 HUMAN|HGNC=29360|UniProtKB=Q7L8J4 Q7L8J4 SH3BP5L PTHR19423:SF8 SH3 DOMAIN-BINDING PROTEIN 5 SH3 DOMAIN-BINDING PROTEIN 5-LIKE enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;guanyl-nucleotide exchange factor activity#GO:0005085;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;kinase inhibitor activity#GO:0019210;protein kinase inhibitor activity#GO:0004860;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;protein kinase regulator activity#GO:0019887;enzyme inhibitor activity#GO:0004857 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 scaffold/adaptor protein#PC00226 HUMAN|HGNC=7897|UniProtKB=O15118 O15118 NPC1 PTHR45727:SF11 NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1 NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1 sterol binding#GO:0032934;binding#GO:0005488;small molecule binding#GO:0036094;lipid binding#GO:0008289;cholesterol binding#GO:0015485;steroid binding#GO:0005496;alcohol binding#GO:0043178 digestion#GO:0007586;lipid transport#GO:0006869;multicellular organismal process#GO:0032501;homeostatic process#GO:0042592;macromolecule localization#GO:0033036;lipid homeostasis#GO:0055088;localization#GO:0051179;establishment of localization#GO:0051234;sterol transport#GO:0015918;cholesterol homeostasis#GO:0042632;organic hydroxy compound transport#GO:0015850;system process#GO:0003008;lipid localization#GO:0010876;transport#GO:0006810;chemical homeostasis#GO:0048878 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=5724|UniProtKB=Q06330 Q06330 RBPJ PTHR10665:SF3 RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700 biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;Notch signaling pathway#GO:0007219;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 Rel homology transcription factor#PC00252;immunoglobulin fold transcription factor#PC00251 Alzheimer disease-presenilin pathway#P00004>CSL#P00158;Notch signaling pathway#P00045>Su(H)#P01101;Angiogenesis#P00005>CSL#P00233 HUMAN|HGNC=19042|UniProtKB=Q96GX5 Q96GX5 MASTL PTHR24356:SF438 SERINE/THREONINE-PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE GREATWALL protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824 cellular process#GO:0009987;regulation of mitotic cell cycle#GO:0007346;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cell cycle#GO:0051726;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;microtubule cytoskeleton#GO:0015630;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=11912|UniProtKB=Q92956 Q92956 TNFRSF14 PTHR46838:SF1 TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 14 TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 14 negative regulation of cell-cell adhesion#GO:0022408;regulation of T cell activation#GO:0050863;regulation of multicellular organismal process#GO:0051239;response to stress#GO:0006950;positive regulation of metabolic process#GO:0009893;defense response to bacterium#GO:0042742;defense response to Gram-negative bacterium#GO:0050829;biological process involved in interspecies interaction between organisms#GO:0044419;regulation of lymphocyte activation#GO:0051249;positive regulation of cell motility#GO:2000147;regulation of leukocyte activation#GO:0002694;regulation of cell activation#GO:0050865;positive regulation of gene expression#GO:0010628;response to external stimulus#GO:0009605;regulation of gene expression#GO:0010468;regulation of leukocyte cell-cell adhesion#GO:1903037;negative regulation of cell adhesion#GO:0007162;response to other organism#GO:0051707;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of biosynthetic process#GO:0009891;regulation of cell motility#GO:2000145;response to bacterium#GO:0009617;regulation of lymphocyte migration#GO:2000401;regulation of leukocyte migration#GO:0002685;positive regulation of cytokine production#GO:0001819;response to external biotic stimulus#GO:0043207;negative regulation of leukocyte cell-cell adhesion#GO:1903038;regulation of leukocyte proliferation#GO:0070663;negative regulation of T cell proliferation#GO:0042130;positive regulation of macromolecule metabolic process#GO:0010604;negative regulation of lymphocyte activation#GO:0051250;negative regulation of leukocyte activation#GO:0002695;response to biotic stimulus#GO:0009607;positive regulation of immune system process#GO:0002684;regulation of mononuclear cell proliferation#GO:0032944;positive regulation of biological process#GO:0048518;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of cytokine production involved in immune response#GO:0002718;response to stimulus#GO:0050896;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;defense response to Gram-positive bacterium#GO:0050830;positive regulation of multicellular organismal process#GO:0051240;negative regulation of cell activation#GO:0050866;regulation of biosynthetic process#GO:0009889;positive regulation of locomotion#GO:0040017;defense response#GO:0006952;negative regulation of cellular process#GO:0048523;regulation of cell migration#GO:0030334;regulation of cell adhesion#GO:0030155;regulation of lymphocyte proliferation#GO:0050670;negative regulation of immune system process#GO:0002683;biological regulation#GO:0065007;positive regulation of immune effector process#GO:0002699;regulation of locomotion#GO:0040012;regulation of cytokine production#GO:0001817;regulation of metabolic process#GO:0019222;negative regulation of cell population proliferation#GO:0008285;positive regulation of cellular process#GO:0048522;positive regulation of cell migration#GO:0030335;regulation of cell population proliferation#GO:0042127;regulation of immune effector process#GO:0002697;negative regulation of T cell activation#GO:0050868;regulation of macromolecule metabolic process#GO:0060255;regulation of T cell proliferation#GO:0042129;regulation of cell-cell adhesion#GO:0022407;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;negative regulation of multicellular organismal process#GO:0051241 membrane#GO:0016020;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=8852|UniProtKB=O75192 O75192 PEX11A PTHR12652:SF22 PEROXISOMAL BIOGENESIS FACTOR 11 PEROXISOMAL MEMBRANE PROTEIN 11A cellular component organization or biogenesis#GO:0071840;organelle fission#GO:0048285;organelle organization#GO:0006996;cellular component organization#GO:0016043;peroxisome organization#GO:0007031;cellular process#GO:0009987 microbody#GO:0042579;peroxisome#GO:0005777;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;peroxisomal membrane#GO:0005778;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090 HUMAN|HGNC=3147|UniProtKB=O95672 O95672 ECEL1 PTHR11733:SF195 ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED ENDOTHELIN-CONVERTING ENZYME-LIKE 1 catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467;protein processing#GO:0016485;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;proteolysis#GO:0006508;metabolic process#GO:0008152 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 protease#PC00190;metalloprotease#PC00153 Endothelin signaling pathway#P00019>ECE1-3#P00585 HUMAN|HGNC=11054|UniProtKB=Q99884 Q99884 SLC6A7 PTHR11616:SF231 SODIUM/CHLORIDE DEPENDENT TRANSPORTER SODIUM-DEPENDENT PROLINE TRANSPORTER amino acid transmembrane transporter activity#GO:0015171;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;secondary active transmembrane transporter activity#GO:0015291;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294;sodium ion transmembrane transporter activity#GO:0015081;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873;carboxylic acid transmembrane transporter activity#GO:0046943;symporter activity#GO:0015293;solute:sodium symporter activity#GO:0015370;amino acid:sodium symporter activity#GO:0005283;monoatomic cation transmembrane transporter activity#GO:0008324 glycine transport#GO:0015816;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;amino acid transmembrane transport#GO:0003333;neutral amino acid transport#GO:0015804;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;carboxylic acid transmembrane transport#GO:1905039;import across plasma membrane#GO:0098739;carboxylic acid transport#GO:0046942;transport#GO:0006810;organic acid transport#GO:0015849;amino acid transport#GO:0006865;establishment of localization#GO:0051234;import into cell#GO:0098657;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;L-amino acid transport#GO:0015807;nitrogen compound transport#GO:0071705;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 primary active transporter#PC00068 HUMAN|HGNC=30394|UniProtKB=Q9Y6D0 Q9Y6D0 SELENOK PTHR16875:SF0 SELENOPROTEIN K SELENOPROTEIN K regulation of biological process#GO:0050789;intracellular monoatomic ion homeostasis#GO:0006873;regulation of calcium-mediated signaling#GO:0050848;homeostatic process#GO:0042592;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;inorganic ion homeostasis#GO:0098771;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;calcium ion homeostasis#GO:0055074;monoatomic ion homeostasis#GO:0050801;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;chemical homeostasis#GO:0048878;regulation of response to stimulus#GO:0048583;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;cellular homeostasis#GO:0019725 organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;cytoplasm#GO:0005737;membrane#GO:0016020;organelle membrane#GO:0031090;Golgi apparatus#GO:0005794;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783 HUMAN|HGNC=10540|UniProtKB=P21673 P21673 SAT1 PTHR10545:SF36 DIAMINE N-ACETYLTRANSFERASE DIAMINE ACETYLTRANSFERASE 1 transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acyltransferase activity#GO:0016746;ion binding#GO:0043167;acetyltransferase activity#GO:0016407;small molecule binding#GO:0036094;binding#GO:0005488;N-acetyltransferase activity#GO:0008080;cation binding#GO:0043169 acetyltransferase#PC00038;transferase#PC00220 HUMAN|HGNC=12480|UniProtKB=Q969M7 Q969M7 UBE2F PTHR24068:SF129 UBIQUITIN-CONJUGATING ENZYME E2 NEDD8-CONJUGATING ENZYME UBE2F ubiquitin-like protein conjugating enzyme activity#GO:0061650;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin conjugating enzyme activity#GO:0061631;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740 protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;cellular process#GO:0009987;protein modification process#GO:0036211;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=2909|UniProtKB=Q9NYJ7 Q9NYJ7 DLL3 PTHR24044:SF308 NOTCH LIGAND FAMILY MEMBER DELTA-LIKE PROTEIN 3 signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515 negative regulation of signaling#GO:0023057;regulation of Notch signaling pathway#GO:0008593;regulation of signaling#GO:0023051;cell communication#GO:0007154;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of cell communication#GO:0010646;signaling#GO:0023052;negative regulation of cellular process#GO:0048523;cell surface receptor signaling pathway#GO:0007166;regulation of response to stimulus#GO:0048583;negative regulation of Notch signaling pathway#GO:0045746;Notch signaling pathway#GO:0007219;cellular process#GO:0009987;signal transduction#GO:0007165;negative regulation of response to stimulus#GO:0048585;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 Angiogenesis#P00005>Delta/Serrate#P00226;Notch signaling pathway#P00045>Delta#P01116 HUMAN|HGNC=24677|UniProtKB=Q86TG1 Q86TG1 TMEM150A PTHR21324:SF6 FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED TRANSMEMBRANE PROTEIN 150A protein localization to cell periphery#GO:1990778;localization within membrane#GO:0051668;localization#GO:0051179;cellular localization#GO:0051641;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657;protein localization to plasma membrane#GO:0072659;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HUMAN|HGNC=28573|UniProtKB=Q8N5U1 Q8N5U1 MS4A15 PTHR23320:SF51 MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 15 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227 HUMAN|HGNC=28156|UniProtKB=Q6N075 Q6N075 SLC61A1 PTHR23516:SF1 SAM (S-ADENOSYL METHIONINE) TRANSPORTER SOLUTE CARRIER FAMILY 61 MEMBER 1 transporter#PC00227 HUMAN|HGNC=5225|UniProtKB=Q03933 Q03933 HSF2 PTHR10015:SF185 HEAT SHOCK TRANSCRIPTION FACTOR HEAT SHOCK FACTOR PROTEIN 2 binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=3722|UniProtKB=O75344 O75344 FKBP6 PTHR46674:SF1 INACTIVE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP6 INACTIVE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP6 protein binding#GO:0005515;binding#GO:0005488;Hsp90 protein binding#GO:0051879;heat shock protein binding#GO:0031072 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;macromolecule biosynthetic process#GO:0009059;male gamete generation#GO:0048232;biological regulation#GO:0065007;biosynthetic process#GO:0009058;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;regulatory ncRNA-mediated gene silencing#GO:0031047;spermatogenesis#GO:0007283;regulatory ncRNA processing#GO:0070918;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;developmental process involved in reproduction#GO:0003006;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;RNA biosynthetic process#GO:0032774;reproductive process#GO:0022414;piRNA processing#GO:0034587;sexual reproduction#GO:0019953;multicellular organismal reproductive process#GO:0048609;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;gene expression#GO:0010467;RNA processing#GO:0006396;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;gamete generation#GO:0007276;negative regulation of metabolic process#GO:0009892;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 chaperone#PC00072 HUMAN|HGNC=9965|UniProtKB=Q9P2R6 Q9P2R6 RERE PTHR13859:SF12 ATROPHIN-RELATED ARGININE-GLUTAMIC ACID DIPEPTIDE REPEATS PROTEIN transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=31789|UniProtKB=Q4VNC0 Q4VNC0 ATP13A5 PTHR45630:SF4 CATION-TRANSPORTING ATPASE-RELATED CATION-TRANSPORTING ATPASE 13A5-RELATED polyamine transmembrane transporter activity#GO:0015203;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 establishment of localization#GO:0051234;cellular homeostasis#GO:0019725;intracellular calcium ion homeostasis#GO:0006874;intracellular chemical homeostasis#GO:0055082;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;transport#GO:0006810;chemical homeostasis#GO:0048878;nitrogen compound transport#GO:0071705;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;transmembrane transport#GO:0055085;localization#GO:0051179;calcium ion homeostasis#GO:0055074;inorganic ion homeostasis#GO:0098771;homeostatic process#GO:0042592;intracellular monoatomic ion homeostasis#GO:0006873 vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;endosome membrane#GO:0010008;endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;vesicle membrane#GO:0012506;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;late endosome#GO:0005770;late endosome membrane#GO:0031902;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588 primary active transporter#PC00068 HUMAN|HGNC=4168|UniProtKB=Q14393 Q14393 GAS6 PTHR24040:SF14 LAMININ G-LIKE DOMAIN-CONTAINING PROTEIN GROWTH ARREST-SPECIFIC PROTEIN 6 signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546 negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166;regulation of apoptotic process#GO:0042981;positive regulation of intracellular signal transduction#GO:1902533;negative regulation of apoptotic process#GO:0043066;positive regulation of response to stimulus#GO:0048584;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;cellular process#GO:0009987;negative regulation of programmed cell death#GO:0043069;positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;positive regulation of signaling#GO:0023056;cell communication#GO:0007154;regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051896;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051897;regulation of cell communication#GO:0010646;signaling#GO:0023052;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=3047|UniProtKB=P57055 P57055 RIPPLY3 PTHR16770:SF4 PROTEIN RIPPLY-LIKE PROTEIN RIPPLY3 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;pattern specification process#GO:0007389;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;negative regulation of macromolecule biosynthetic process#GO:0010558;embryonic pattern specification#GO:0009880;embryo development#GO:0009790;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;multicellular organism development#GO:0007275;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=12231|UniProtKB=A0A0A6YYG2 A0A0A6YYG2 TRBV6-6 PTHR23268:SF19 T-CELL RECEPTOR BETA CHAIN T CELL RECEPTOR BETA VARIABLE 6-2-RELATED signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=6872|UniProtKB=P53779 P53779 MAPK10 PTHR24055:SF162 MITOGEN-ACTIVATED PROTEIN KINASE MITOGEN-ACTIVATED PROTEIN KINASE 10 catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;biological regulation#GO:0065007;signaling#GO:0023052;intracellular signaling cassette#GO:0141124;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;JNK cascade#GO:0007254;intracellular signal transduction#GO:0035556;MAPK cascade#GO:0000165;cell communication#GO:0007154 nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 Interferon-gamma signaling pathway#P00035>Serine kinase#P00955;Angiogenesis#P00005>JNK1#P00221;Alzheimer disease-amyloid secretase pathway#P00003>MAPK#P00099;Ras Pathway#P04393>JNK#P04572;B cell activation#P00010>Jnk#P00402;PDGF signaling pathway#P00047>ERK#P01143;CCKR signaling map#P06959>MAPK8-10#P07090;Apoptosis signaling pathway#P00006>JNK#P00274;Integrin signalling pathway#P00034>ERK#P00907;Parkinson disease#P00049>SAPK#P01219;Toll receptor signaling pathway#P00054>JNK#P01375;Oxidative stress response#P00046>JNK1/2#P01129;FGF signaling pathway#P00021>JNK1-3#P00628;TGF-beta signaling pathway#P00052>JNK#P01284;T cell activation#P00053>Jnk#P01336;FAS signaling pathway#P00020>JNK#P00615;EGF receptor signaling pathway#P00018>JNK1-3#P00545;Integrin signalling pathway#P00034>Jnk#P00951 HUMAN|HGNC=18877|UniProtKB=P59540 P59540 TAS2R46 PTHR11394:SF66 TASTE RECEPTOR TYPE 2 TASTE RECEPTOR TYPE 2 MEMBER 46 bitter taste receptor activity#GO:0033038;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;taste receptor activity#GO:0008527;transmembrane signaling receptor activity#GO:0004888 detection of chemical stimulus involved in sensory perception of bitter taste#GO:0001580;system process#GO:0003008;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;sensory perception of taste#GO:0050909;detection of chemical stimulus involved in sensory perception of taste#GO:0050912;nervous system process#GO:0050877;sensory perception#GO:0007600;multicellular organismal process#GO:0032501;response to stimulus#GO:0050896;response to chemical#GO:0042221;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;detection of chemical stimulus#GO:0009593;sensory perception of bitter taste#GO:0050913 cellular anatomical structure#GO:0110165;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=14368|UniProtKB=Q9GZN4 Q9GZN4 PRSS22 PTHR24253:SF6 TRANSMEMBRANE PROTEASE SERINE BRAIN-SPECIFIC SERINE PROTEASE 4 serine hydrolase activity#GO:0017171;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;serine-type peptidase activity#GO:0008236;catalytic activity#GO:0003824 metabolic process#GO:0008152;proteolysis#GO:0006508;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein processing#GO:0016485;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467 serine protease#PC00203;protease#PC00190;protein modifying enzyme#PC00260 HUMAN|HGNC=40033|UniProtKB=Q9H693 Q9H693 C16orf95 PTHR14693:SF0 RIKEN CDNA 1700018B08 RIKEN CDNA 1700018B08 GENE HUMAN|HGNC=25031|UniProtKB=Q6NWY9 Q6NWY9 PRPF40B PTHR11864:SF1 PRE-MRNA-PROCESSING PROTEIN PRP40 PRE-MRNA-PROCESSING FACTOR 40 HOMOLOG B binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377 intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;spliceosomal snRNP complex#GO:0097525;spliceosomal complex#GO:0005681;U2-type spliceosomal complex#GO:0005684;intracellular membrane-bounded organelle#GO:0043231;U2-type prespliceosome#GO:0071004;cellular anatomical structure#GO:0110165;organelle#GO:0043226;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;small nuclear ribonucleoprotein complex#GO:0030532;protein-containing complex#GO:0032991;U1 snRNP#GO:0005685 HUMAN|HGNC=8788|UniProtKB=O43924 O43924 PDE6D PTHR12976:SF0 RETINAL ROD RHODOPSIN-SENSITIVE CGMP 3',5'-CYCLIC PHOSPHODIESTERASE DELTA-SUBUNIT RETINAL ROD RHODOPSIN-SENSITIVE CGMP 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT DELTA cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;phosphodiesterase#PC00185 HUMAN|HGNC=11268|UniProtKB=Q9UBC9 Q9UBC9 SPRR3 PTHR23263:SF125 SMALL PROLINE-RICH PROTEIN SMALL PROLINE-RICH PROTEIN 3 structural protein#PC00211 HUMAN|HGNC=17908|UniProtKB=O43298 O43298 ZBTB43 PTHR46105:SF15 AGAP004733-PA ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 43 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=7393|UniProtKB=P04731 P04731 MT1A PTHR23299:SF49 METALLOTHIONEIN METALLOTHIONEIN-1A small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;metal ion binding#GO:0046872;cation binding#GO:0043169 inorganic ion homeostasis#GO:0098771;cellular response to chemical stimulus#GO:0070887;cellular response to stimulus#GO:0051716;intracellular monoatomic ion homeostasis#GO:0006873;homeostatic process#GO:0042592;response to stimulus#GO:0050896;response to toxic substance#GO:0009636;response to metal ion#GO:0010038;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;chemical homeostasis#GO:0048878;response to cadmium ion#GO:0046686;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801;response to stress#GO:0006950;detoxification of inorganic compound#GO:0061687;detoxification#GO:0098754;response to chemical#GO:0042221 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 defense/immunity protein#PC00090 HUMAN|HGNC=29404|UniProtKB=Q96CT2 Q96CT2 KLHL29 PTHR24412:SF10 KELCH PROTEIN KELCH-LIKE PROTEIN 29 ubiquitin-like ligase-substrate adaptor activity#GO:1990756;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;enzyme-substrate adaptor activity#GO:0140767 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987 transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;Cul3-RING ubiquitin ligase complex#GO:0031463;ubiquitin ligase complex#GO:0000151;cullin-RING ubiquitin ligase complex#GO:0031461;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=25736|UniProtKB=Q96BR6 Q96BR6 ZNF669 PTHR24381:SF386 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 669 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=28733|UniProtKB=Q6JVE5 Q6JVE5 LCN12 PTHR11430:SF12 LIPOCALIN EPIDIDYMAL-SPECIFIC LIPOCALIN-12 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 transfer/carrier protein#PC00219 HUMAN|HGNC=618|UniProtKB=O14791 O14791 APOL1 PTHR14096:SF55 APOLIPOPROTEIN L APOLIPOPROTEIN L1 binding#GO:0005488;lipid binding#GO:0008289 cellular anatomical structure#GO:0110165;membrane#GO:0016020 apolipoprotein#PC00052;transfer/carrier protein#PC00219 HUMAN|HGNC=6183|UniProtKB=Q15811 Q15811 ITSN1 PTHR11216:SF68 EH DOMAIN INTERSECTIN-1 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 localization#GO:0051179;cellular localization#GO:0051641;clathrin-dependent endocytosis#GO:0072583;synaptic vesicle endocytosis#GO:0048488;endocytosis#GO:0006897;transport#GO:0006810;synaptic vesicle cycle#GO:0099504;intracellular transport#GO:0046907;receptor-mediated endocytosis#GO:0006898;endosomal transport#GO:0016197;vesicle-mediated transport in synapse#GO:0099003;import into cell#GO:0098657;establishment of localization#GO:0051234;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;synaptic vesicle recycling#GO:0036465 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cell periphery#GO:0071944;vesicle#GO:0031982;membrane#GO:0016020;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;organelle#GO:0043226 membrane traffic protein#PC00150 HUMAN|HGNC=1044|UniProtKB=P21810 P21810 BGN PTHR45712:SF11 AGAP008170-PA BIGLYCAN cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=9019|UniProtKB=Q9Y2B9 Q9Y2B9 PKIG PTHR15416:SF5 CAMP-DEPENDENT PROTEIN KINASE INHIBITOR/PKI CAMP-DEPENDENT PROTEIN KINASE INHIBITOR GAMMA molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;protein kinase inhibitor activity#GO:0004860;protein kinase regulator activity#GO:0019887;kinase inhibitor activity#GO:0019210;enzyme inhibitor activity#GO:0004857 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 kinase inhibitor#PC00139;kinase modulator#PC00140 HUMAN|HGNC=9617|UniProtKB=Q13882 Q13882 PTK6 PTHR24418:SF265 TYROSINE-PROTEIN KINASE PROTEIN-TYROSINE KINASE 6 signaling receptor binding#GO:0005102;binding#GO:0005488;non-membrane spanning protein tyrosine kinase activity#GO:0004715;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein binding#GO:0005515;protein kinase activity#GO:0004672;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein tyrosine kinase activity#GO:0004713;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;developmental process#GO:0032502;cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;cellular developmental process#GO:0048869;enzyme-linked receptor protein signaling pathway#GO:0007167 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 non-receptor tyrosine protein kinase#PC00168 HUMAN|HGNC=3284|UniProtKB=Q14240 Q14240 EIF4A2 PTHR24031:SF762 RNA HELICASE EUKARYOTIC INITIATION FACTOR 4A-II protein biosynthetic process#GO:0160307;gene expression#GO:0010467;cytoplasmic translation#GO:0002181;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cytoplasmic translational initiation#GO:0002183;metabolic process#GO:0008152;translation#GO:0006412;translational initiation#GO:0006413 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;membraneless organelle#GO:0043228;cytoplasmic stress granule#GO:0010494;intracellular protein-containing complex#GO:0140535;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;nucleus#GO:0005634 RNA helicase#PC00032;RNA metabolism protein#PC00031 HUMAN|HGNC=20852|UniProtKB=Q96S15 Q96S15 WDR24 PTHR46200:SF1 GATOR COMPLEX PROTEIN WDR24 GATOR2 COMPLEX PROTEIN WDR24 regulation of macroautophagy#GO:0016241;response to stress#GO:0006950;positive regulation of autophagy#GO:0010508;regulation of TOR signaling#GO:0032006;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;cellular response to amino acid starvation#GO:0034198;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;cellular response to stress#GO:0033554;positive regulation of signaling#GO:0023056;positive regulation of metabolic process#GO:0009893;regulation of autophagy#GO:0010506;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;positive regulation of macroautophagy#GO:0016239;cellular response to starvation#GO:0009267;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;cellular response to nutrient levels#GO:0031669;positive regulation of catabolic process#GO:0009896;regulation of catabolic process#GO:0009894;regulation of TORC1 signaling#GO:1903432;positive regulation of TORC1 signaling#GO:1904263;regulation of metabolic process#GO:0019222;response to nutrient levels#GO:0031667;positive regulation of cellular process#GO:0048522;positive regulation of response to stimulus#GO:0048584;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of TOR signaling#GO:0032008;positive regulation of signal transduction#GO:0009967;response to starvation#GO:0042594;cellular response to stimulus#GO:0051716;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646 membrane#GO:0016020;vacuole#GO:0005773;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;vacuolar membrane#GO:0005774;Seh1-associated complex#GO:0035859 HUMAN|HGNC=55138|UniProtKB=A0A7P0TBJ1 A0A7P0TBJ1 HAPSTR2 PTHR31624:SF2 UPF0472 PROTEIN C16ORF72 HUWE1-ASSOCIATED PROTEIN MODIFYING STRESS RESPONSES 2 HUMAN|HGNC=17474|UniProtKB=Q96AP7 Q96AP7 ESAM PTHR44549:SF1 ENDOTHELIAL CELL-SELECTIVE ADHESION MOLECULE ENDOTHELIAL CELL-SELECTIVE ADHESION MOLECULE cell adhesion molecule binding#GO:0050839;cell adhesion mediator activity#GO:0098631;binding#GO:0005488;cell-cell adhesion mediator activity#GO:0098632;protein binding#GO:0005515 cell adhesion#GO:0007155;cellular process#GO:0009987;homophilic cell-cell adhesion#GO:0007156;cell-cell adhesion#GO:0098609 cell junction#GO:0030054;anchoring junction#GO:0070161;adherens junction#GO:0005912;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell-cell junction#GO:0005911;cell periphery#GO:0071944 cell adhesion molecule#PC00069 HUMAN|HGNC=26075|UniProtKB=Q9NWS0 Q9NWS0 PIH1D1 PTHR22997:SF0 PIH1 DOMAIN-CONTAINING PROTEIN 1 PIH1 DOMAIN-CONTAINING PROTEIN 1 rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;protein-containing complex organization#GO:0043933;protein-RNA complex organization#GO:0071826;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular component assembly#GO:0022607;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;protein-RNA complex assembly#GO:0022618;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=26796|UniProtKB=Q96D98 Q96D98 EID2B PTHR15556:SF4 EP300-INTERACTING INHIBITOR OF DIFFERENTIATION 2-RELATED EP300-INTERACTING INHIBITOR OF DIFFERENTIATION 2B transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714 negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=24697|UniProtKB=Q96N46 Q96N46 TTC14 PTHR23184:SF9 TETRATRICOPEPTIDE REPEAT PROTEIN 14 TETRATRICOPEPTIDE REPEAT PROTEIN 14 HUMAN|HGNC=7930|UniProtKB=Q86SE8 Q86SE8 NPM2 PTHR22747:SF14 NUCLEOPLASMIN NUCLEOPLASMIN-2 nucleic acid binding#GO:0003676;binding#GO:0005488;chromatin binding#GO:0003682;histone binding#GO:0042393;RNA binding#GO:0003723;protein binding#GO:0005515 cellular process#GO:0009987;cellular component organization#GO:0016043;chromatin remodeling#GO:0006338;chromatin organization#GO:0006325;cellular component organization or biogenesis#GO:0071840 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;organelle lumen#GO:0043233;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;membraneless organelle#GO:0043228 chaperone#PC00072 HUMAN|HGNC=7390|UniProtKB=Q2TV78 Q2TV78 MST1L PTHR24261:SF12 PLASMINOGEN-RELATED HEPATOCYTE GROWTH FACTOR-LIKE PROTEIN-RELATED hydrolase activity#GO:0016787;protein binding#GO:0005515;protein tyrosine kinase binding#GO:1990782;kinase binding#GO:0019900;signaling receptor binding#GO:0005102;binding#GO:0005488;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;catalytic activity, acting on a protein#GO:0140096;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity#GO:0003824;receptor tyrosine kinase binding#GO:0030971 regulation of signaling#GO:0023051;regulation of receptor signaling pathway via JAK-STAT#GO:0046425;regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cell communication#GO:0010646;regulation of receptor signaling pathway via STAT#GO:1904892 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 serine protease#PC00203;protein modifying enzyme#PC00260 HUMAN|HGNC=24659|UniProtKB=Q8IYI6 Q8IYI6 EXOC8 PTHR21426:SF12 EXOCYST COMPLEX COMPONENT 8 EXOCYST COMPLEX COMPONENT 8 macromolecule localization#GO:0033036;cellular process#GO:0009987;Golgi to plasma membrane transport#GO:0006893;vesicle-mediated transport#GO:0016192;localization within membrane#GO:0051668;transport#GO:0006810;Golgi vesicle transport#GO:0048193;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;vesicle-mediated transport to the plasma membrane#GO:0098876;intracellular protein localization#GO:0008104;post-Golgi vesicle-mediated transport#GO:0006892 intracellular anatomical structure#GO:0005622;vesicle tethering complex#GO:0099023;cell periphery#GO:0071944;cell cortex#GO:0005938;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;exocyst#GO:0000145 HUMAN|HGNC=44447|UniProtKB=D6RCP7 D6RCP7 USP17L19 PTHR24006:SF651 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE INACTIVE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 17-LIKE PROTEIN 4-RELATED deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;cysteine-type deubiquitinase activity#GO:0004843;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity, acting on a protein#GO:0140096 regulation of apoptotic process#GO:0042981;regulation of protein stability#GO:0031647;regulation of biological process#GO:0050789;regulation of programmed cell death#GO:0043067;regulation of biological quality#GO:0065008;biological regulation#GO:0065007;regulation of cellular process#GO:0050794 nucleus#GO:0005634;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 protease#PC00190;cysteine protease#PC00081 HUMAN|HGNC=6188|UniProtKB=P78504 P78504 JAG1 PTHR24044:SF448 NOTCH LIGAND FAMILY MEMBER PROTEIN JAGGED-1 protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488 intercellular signal molecule#PC00207 Notch signaling pathway#P00045>Serrate#P01104;Angiogenesis#P00005>Delta/Serrate#P00226;Notch signaling pathway#P00045>Next#P01103 HUMAN|HGNC=16154|UniProtKB=Q969T3 Q969T3 SNX21 PTHR20939:SF10 SORTING NEXIN 20, 21 SORTING NEXIN-21 lipid binding#GO:0008289;phosphatidylinositol phosphate binding#GO:1901981;phospholipid binding#GO:0005543;binding#GO:0005488 vesicle membrane#GO:0012506;membrane#GO:0016020;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;cytoplasm#GO:0005737;early endosome membrane#GO:0031901;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;endosome#GO:0005768;endosome membrane#GO:0010008;membrane-bounded organelle#GO:0043227;early endosome#GO:0005769;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HUMAN|HGNC=4453|UniProtKB=P78333 P78333 GPC5 PTHR10822:SF12 GLYPICAN GLYPICAN-5 regulation of response to stimulus#GO:0048583;regulation of localization#GO:0032879;positive regulation of canonical Wnt signaling pathway#GO:0090263;cellular process#GO:0009987;regulation of protein localization to membrane#GO:1905475;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of canonical Wnt signaling pathway#GO:0060828;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;cell migration#GO:0016477;positive regulation of response to stimulus#GO:0048584;positive regulation of Wnt signaling pathway#GO:0030177;regulation of signaling#GO:0023051;regulation of protein localization#GO:0032880;positive regulation of signaling#GO:0023056;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;regulation of Wnt signaling pathway#GO:0030111;regulation of cell communication#GO:0010646;cell motility#GO:0048870;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165;cell surface#GO:0009986 scaffold/adaptor protein#PC00226 HUMAN|HGNC=28963|UniProtKB=Q15006 Q15006 EMC2 PTHR12760:SF0 TETRATRICOPEPTIDE REPEAT PROTEIN ER MEMBRANE PROTEIN COMPLEX SUBUNIT 2 molecular carrier activity#GO:0140104;protein carrier activity#GO:0140597;membrane insertase activity#GO:0032977 cellular localization#GO:0051641;localization#GO:0051179;localization within membrane#GO:0051668;protein localization to organelle#GO:0033365;endoplasmic reticulum organization#GO:0007029;protein insertion into ER membrane#GO:0045048;cellular component organization#GO:0016043;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;protein insertion into membrane#GO:0051205;tail-anchored membrane protein insertion into ER membrane#GO:0071816;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of protein localization to membrane#GO:0090150;organelle organization#GO:0006996;macromolecule localization#GO:0033036 endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;organelle membrane#GO:0031090;endoplasmic reticulum protein-containing complex#GO:0140534;membrane#GO:0016020;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasm#GO:0005737;EMC complex#GO:0072546;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;membrane protein complex#GO:0098796;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;intracellular membrane-bounded organelle#GO:0043231 chaperone#PC00072 HUMAN|HGNC=23719|UniProtKB=Q96FM1 Q96FM1 PGAP3 PTHR13148:SF0 PER1-RELATED GPI-SPECIFIC PHOSPHOLIPASE A2-LIKE PGAP3 hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;hydrolase activity#GO:0016787 biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467;GPI anchored protein biosynthesis#GO:0180046;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;membrane-bounded organelle#GO:0043227;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 HUMAN|HGNC=26698|UniProtKB=Q8N9V2 Q8N9V2 TRIML1 PTHR24103:SF676 E3 UBIQUITIN-PROTEIN LIGASE TRIM E3 UBIQUITIN-PROTEIN LIGASE TRIML1-RELATED ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740 innate immune response#GO:0045087;defense response#GO:0006952;response to external stimulus#GO:0009605;immune system process#GO:0002376;defense response to other organism#GO:0098542;response to stimulus#GO:0050896;response to other organism#GO:0051707;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;immune response#GO:0006955;defense response to symbiont#GO:0140546 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=10384|UniProtKB=P62280 P62280 RPS11 PTHR10744:SF9 40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER SMALL RIBOSOMAL SUBUNIT PROTEIN US17 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytosolic ribosome#GO:0022626;cytosol#GO:0005829;ribosome#GO:0005840;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;cytosolic small ribosomal subunit#GO:0022627;intracellular organelle#GO:0043229;small ribosomal subunit#GO:0015935 ribosomal protein#PC00202 HUMAN|HGNC=11283|UniProtKB=P12931 P12931 SRC PTHR24418:SF53 TYROSINE-PROTEIN KINASE PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein binding#GO:0005515;non-membrane spanning protein tyrosine kinase activity#GO:0004715;binding#GO:0005488;signaling receptor binding#GO:0005102 negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;cellular response to endogenous stimulus#GO:0071495;cell differentiation#GO:0030154;response to stimulus#GO:0050896;cellular response to hormone stimulus#GO:0032870;signaling#GO:0023052;negative regulation of signaling#GO:0023057;cellular response to chemical stimulus#GO:0070887;regulation of intracellular signal transduction#GO:1902531;cell adhesion#GO:0007155;regulation of signaling#GO:0023051;hormone-mediated signaling pathway#GO:0009755;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;response to hormone#GO:0009725;negative regulation of programmed cell death#GO:0043069;signal transduction#GO:0007165;cellular process#GO:0009987;response to chemical#GO:0042221;cellular response to lipid#GO:0071396;response to lipid#GO:0033993;negative regulation of signal transduction#GO:0009968;cell surface receptor signaling pathway#GO:0007166;negative regulation of intrinsic apoptotic signaling pathway#GO:2001243;regulation of apoptotic process#GO:0042981;cellular response to steroid hormone stimulus#GO:0071383;regulation of extrinsic apoptotic signaling pathway#GO:2001236;steroid hormone receptor signaling pathway#GO:0043401;regulation of intrinsic apoptotic signaling pathway#GO:2001242;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;intracellular receptor signaling pathway#GO:0030522;regulation of cell communication#GO:0010646;response to steroid hormone#GO:0048545;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;negative regulation of apoptotic signaling pathway#GO:2001234;regulation of apoptotic signaling pathway#GO:2001233;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;intracellular signal transduction#GO:0035556;nuclear receptor-mediated steroid hormone signaling pathway#GO:0030518;negative regulation of extrinsic apoptotic signaling pathway#GO:2001237;ERBB signaling pathway#GO:0038127;nuclear receptor-mediated signaling pathway#GO:0141193;negative regulation of apoptotic process#GO:0043066;epidermal growth factor receptor signaling pathway#GO:0007173;negative regulation of response to stimulus#GO:0048585;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;regulation of response to stimulus#GO:0048583;cellular developmental process#GO:0048869 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 non-receptor tyrosine protein kinase#PC00168 Cadherin signaling pathway#P00012>Src#P00468;CCKR signaling map#P06959>p62 SRC#P07047;Parkinson disease#P00049>Src kinase#P01230;Integrin signalling pathway#P00034>Src#P00940;Angiogenesis#P00005>Src#P00184;CCKR signaling map#P06959>p54 SRC#P07109;CCKR signaling map#P06959>SRC#P07202;CCKR signaling map#P06959>SRC @Galphaq#P07163;Gonadotropin-releasing hormone receptor pathway#P06664>SRC#P06844;CCKR signaling map#P06959>p60 SRC#P07207 HUMAN|HGNC=20957|UniProtKB=Q5VUM1 Q5VUM1 SDHAF4 PTHR28524:SF3 SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL chaperone#PC00072 HUMAN|HGNC=28513|UniProtKB=Q8IYS2 Q8IYS2 KIAA2013 PTHR31386:SF2 UNCHARACTERIZED PROTEIN KIAA2013 RIKEN CDNA 2510039O18 GENE LIKE HUMAN|HGNC=11810|UniProtKB=Q13118 Q13118 KLF10 PTHR23235:SF64 KRUEPPEL-LIKE TRANSCRIPTION FACTOR KRUEPPEL-LIKE FACTOR 10 RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=12719|UniProtKB=Q86Y07 Q86Y07 VRK2 PTHR11909:SF100 CASEIN KINASE-RELATED SERINE_THREONINE-PROTEIN KINASE VRK2 transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 cell communication#GO:0007154;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stress#GO:0006950 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=25832|UniProtKB=A0PJE2 A0PJE2 DHRS12 PTHR44656:SF7 DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 12 DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 12 metabolite interconversion enzyme#PC00262;dehydrogenase#PC00092 HUMAN|HGNC=23826|UniProtKB=Q6ZMG9 Q6ZMG9 CERS6 PTHR12560:SF43 LONGEVITY ASSURANCE FACTOR 1 LAG1 CERAMIDE SYNTHASE 6 acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740 lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;ceramide metabolic process#GO:0006672;metabolic process#GO:0008152;sphingolipid metabolic process#GO:0006665;sphingolipid biosynthetic process#GO:0030148;ceramide biosynthetic process#GO:0046513;lipid metabolic process#GO:0006629 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 metabolite interconversion enzyme#PC00262;transferase#PC00220 HUMAN|HGNC=29511|UniProtKB=Q9UPN4 Q9UPN4 CEP131 PTHR31540:SF1 CENTROSOMAL PROTEIN OF 131 KDA CENTROSOMAL PROTEIN OF 131 KDA cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;cilium movement involved in cell motility#GO:0060294;intraciliary transport involved in cilium assembly#GO:0035735;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;cell projection assembly#GO:0030031;motile cilium assembly#GO:0044458;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;gamete generation#GO:0007276;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cellular process involved in reproduction in multicellular organism#GO:0022412;cell development#GO:0048468;cellular component organization#GO:0016043;cilium assembly#GO:0060271;sperm motility#GO:0097722;cellular localization#GO:0051641;sperm flagellum assembly#GO:0120316;cilium-dependent cell motility#GO:0060285;cilium organization#GO:0044782;spermatid differentiation#GO:0048515;microtubule-based transport#GO:0099111;cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;cytoskeleton-dependent intracellular transport#GO:0030705;male gamete generation#GO:0048232;plasma membrane bounded cell projection organization#GO:0120036;establishment of localization#GO:0051234;cellular developmental process#GO:0048869;transport along microtubule#GO:0010970;sperm axoneme assembly#GO:0007288;intracellular transport#GO:0046907;flagellated sperm motility#GO:0030317;plasma membrane bounded cell projection assembly#GO:0120031;transport#GO:0006810;developmental process#GO:0032502;spermatogenesis#GO:0007283;microtubule-based movement#GO:0007018;cell motility#GO:0048870;reproductive process#GO:0022414;intraciliary transport#GO:0042073;developmental process involved in reproduction#GO:0003006;germ cell development#GO:0007281;anatomical structure development#GO:0048856;microtubule cytoskeleton organization#GO:0000226;localization#GO:0051179;multicellular organismal reproductive process#GO:0048609;axoneme assembly#GO:0035082;organelle assembly#GO:0070925;microtubule bundle formation#GO:0001578;spermatid development#GO:0007286;sexual reproduction#GO:0019953 HUMAN|HGNC=8767|UniProtKB=Q8N8D1 Q8N8D1 PDCD7 PTHR48190:SF2 PROGRAMMED CELL DEATH PROTEIN 7 PROGRAMMED CELL DEATH PROTEIN 7 nucleus#GO:0005634;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;U12-type spliceosomal complex#GO:0005689;nuclear protein-containing complex#GO:0140513 HUMAN|HGNC=4133|UniProtKB=O43603 O43603 GALR2 PTHR24230:SF13 G-PROTEIN COUPLED RECEPTOR GALANIN RECEPTOR TYPE 2 transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;neuropeptide receptor activity#GO:0008188;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;neuropeptide signaling pathway#GO:0007218 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HUMAN|HGNC=26239|UniProtKB=Q9H5V9 Q9H5V9 STEEP1 PTHR46355:SF1 UPF0428 PROTEIN CXORF56 STING ER EXIT PROTEIN endomembrane system organization#GO:0010256;membrane organization#GO:0061024;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;organelle organization#GO:0006996;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;transport#GO:0006810;Golgi vesicle transport#GO:0048193;endoplasmic reticulum membrane organization#GO:0090158;intracellular transport#GO:0046907;endoplasmic reticulum organization#GO:0007029;cellular component organization#GO:0016043;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;localization#GO:0051179 HUMAN|HGNC=2439|UniProtKB=Q99062 Q99062 CSF3R PTHR23036:SF103 CYTOKINE RECEPTOR GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR cytokine receptor activity#GO:0004896;signaling receptor activity#GO:0038023;cytokine binding#GO:0019955;immune receptor activity#GO:0140375;transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488;molecular transducer activity#GO:0060089;protein binding#GO:0005515 regulation of cell population proliferation#GO:0042127;cell communication#GO:0007154;response to peptide#GO:1901652;cytokine-mediated signaling pathway#GO:0019221;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;positive regulation of cell population proliferation#GO:0008284;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;cell surface receptor signaling pathway#GO:0007166;response to chemical#GO:0042221;response to cytokine#GO:0034097;biological regulation#GO:0065007;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of cellular process#GO:0048522 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane#GO:0016020;signaling receptor complex#GO:0043235;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=17196|UniProtKB=Q8NG08 Q8NG08 HELB PTHR43788:SF19 DNA2/NAM7 HELICASE FAMILY MEMBER DNA HELICASE B ATP-dependent activity, acting on DNA#GO:0008094;ATP-dependent activity#GO:0140657;catalytic activity, acting on DNA#GO:0140097;helicase activity#GO:0004386;DNA helicase activity#GO:0003678;isomerase activity#GO:0016853;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543 regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of response to stimulus#GO:0048585;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of DNA metabolic process#GO:0051053;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;regulation of response to stress#GO:0080134;regulation of response to stimulus#GO:0048583;regulation of DNA repair#GO:0006282;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;negative regulation of DNA recombination#GO:0045910;cellular response to stimulus#GO:0051716;DNA replication#GO:0006260;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of double-strand break repair#GO:2000779;response to stress#GO:0006950;cellular process#GO:0009987;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;negative regulation of double-strand break repair via homologous recombination#GO:2000042;negative regulation of biological process#GO:0048519;regulation of DNA metabolic process#GO:0051052;regulation of biological process#GO:0050789;regulation of double-strand break repair via homologous recombination#GO:0010569;response to stimulus#GO:0050896;negative regulation of metabolic process#GO:0009892;regulation of DNA recombination#GO:0000018;cellular response to stress#GO:0033554;DNA-templated DNA replication#GO:0006261;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of cellular response to stress#GO:0080135 DNA metabolism protein#PC00009 HUMAN|HGNC=10024|UniProtKB=P12271 P12271 RLBP1 PTHR10174:SF200 ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED RETINALDEHYDE-BINDING PROTEIN 1 binding#GO:0005488;small molecule binding#GO:0036094;anion binding#GO:0043168;ion binding#GO:0043167;phosphatidylinositol bisphosphate binding#GO:1902936 transfer/carrier protein#PC00219 HUMAN|HGNC=18655|UniProtKB=Q9UDX4 Q9UDX4 SEC14L3 PTHR23324:SF62 SEC14 RELATED PROTEIN SEC14-LIKE PROTEIN 3 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 transfer/carrier protein#PC00219 HUMAN|HGNC=6511|UniProtKB=O95461 O95461 LARGE1 PTHR12270:SF48 GLYCOSYLTRANSFERASE-RELATED XYLOSYL- AND GLUCURONYLTRANSFERASE LARGE1 glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194;transferase activity#GO:0016740;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;xylosyltransferase activity#GO:0042285;glucuronosyltransferase activity#GO:0015020;pentosyltransferase activity#GO:0016763 biosynthetic process#GO:0009058;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;protein O-linked glycosylation#GO:0006493;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;protein O-linked glycosylation via mannose#GO:0035269 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;glycosyltransferase#PC00111 HUMAN|HGNC=2479|UniProtKB=O76096 O76096 CST7 PTHR47141:SF1 CYSTATIN-F CYSTATIN-F endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772;enzyme inhibitor activity#GO:0004857;enzyme regulator activity#GO:0030234;cysteine-type endopeptidase inhibitor activity#GO:0004869;molecular function inhibitor activity#GO:0140678;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;peptidase regulator activity#GO:0061134 regulation of immune system process#GO:0002682;negative regulation of inflammatory response#GO:0050728;negative regulation of defense response#GO:0031348;regulation of cellular process#GO:0050794;regulation of developmental process#GO:0050793;negative regulation of multicellular organismal process#GO:0051241;negative regulation of biological process#GO:0048519;regulation of leukocyte activation#GO:0002694;regulation of multicellular organismal development#GO:2000026;regulation of cell activation#GO:0050865;positive regulation of multicellular organismal process#GO:0051240;regulation of biological process#GO:0050789;regulation of nervous system development#GO:0051960;regulation of inflammatory response#GO:0050727;regulation of defense response#GO:0031347;regulation of response to external stimulus#GO:0032101;negative regulation of response to stimulus#GO:0048585;negative regulation of leukocyte activation#GO:0002695;regulation of multicellular organismal process#GO:0051239;negative regulation of response to external stimulus#GO:0032102;negative regulation of immune system process#GO:0002683;biological regulation#GO:0065007;regulation of macrophage activation#GO:0043030;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;negative regulation of cell activation#GO:0050866;regulation of response to stress#GO:0080134;negative regulation of cellular process#GO:0048523;regulation of system process#GO:0044057;regulation of response to stimulus#GO:0048583 Golgi apparatus#GO:0005794;endoplasmic reticulum#GO:0005783;lytic vacuole#GO:0000323;endomembrane system#GO:0012505;late endosome#GO:0005770;cytoplasm#GO:0005737;vacuole#GO:0005773;endosome#GO:0005768;extracellular region#GO:0005576;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular vesicle#GO:0097708;lysosome#GO:0005764;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=29242|UniProtKB=A1X283 A1X283 SH3PXD2B PTHR15706:SF26 SH3 MULTIPLE DOMAIN SH3 AND PX DOMAIN-CONTAINING PROTEIN 2B molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;enzyme activator activity#GO:0008047 reactive oxygen species metabolic process#GO:0072593;metabolic process#GO:0008152;cellular process#GO:0009987;superoxide metabolic process#GO:0006801 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HUMAN|HGNC=15315|UniProtKB=Q8NH50 Q8NH50 OR8K5 PTHR48018:SF13 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 8K5 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 multicellular organismal process#GO:0032501;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606;sensory perception of smell#GO:0007608;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;nervous system process#GO:0050877;sensory perception#GO:0007600 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=15664|UniProtKB=Q9NYU1 Q9NYU1 UGGT2 PTHR11226:SF1 UDP-GLUCOSE GLYCOPROTEIN:GLUCOSYLTRANSFERASE UDP-GLUCOSE:GLYCOPROTEIN GLUCOSYLTRANSFERASE 2 glucosyltransferase activity#GO:0046527;glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194;UDP-glucosyltransferase activity#GO:0035251;hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740 metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487;glycoprotein biosynthetic process#GO:0009101;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;biosynthetic process#GO:0009058 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 glycosyltransferase#PC00111 HUMAN|HGNC=18269|UniProtKB=Q9P203 Q9P203 BTBD7 PTHR16064:SF5 BTB POZ DOMAIN CONTAINING 7 BTB_POZ DOMAIN-CONTAINING PROTEIN 7 regulation of biological process#GO:0050789;biological regulation#GO:0065007;regulation of developmental process#GO:0050793;regulation of multicellular organismal process#GO:0051239;regulation of anatomical structure morphogenesis#GO:0022603 HUMAN|HGNC=25150|UniProtKB=Q6NUJ5 Q6NUJ5 PWWP2B PTHR23068:SF6 DNA CYTOSINE-5- -METHYLTRANSFERASE 3-RELATED PWWP DOMAIN-CONTAINING PROTEIN 2B organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 DNA methyltransferase#PC00013 HUMAN|HGNC=4161|UniProtKB=Q14392 Q14392 LRRC32 PTHR24373:SF354 SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN TRANSFORMING GROWTH FACTOR BETA ACTIVATOR LRRC32 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=18745|UniProtKB=Q9Y6G9 Q9Y6G9 DYNC1LI1 PTHR12688:SF2 DYNEIN LIGHT INTERMEDIATE CHAIN CYTOPLASMIC DYNEIN 1 LIGHT INTERMEDIATE CHAIN 1 protein binding#GO:0005515;binding#GO:0005488 microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;microtubule-based movement#GO:0007018;cytoskeleton organization#GO:0007010 catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687;kinetochore#GO:0000776;dynein complex#GO:0030286;chromosome#GO:0005694;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microtubule organizing center#GO:0005815;centrosome#GO:0005813;chromosome, centromeric region#GO:0000775;cytoskeleton#GO:0005856;condensed chromosome#GO:0000793;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;condensed chromosome, centromeric region#GO:0000779;cytoplasmic dynein complex#GO:0005868;intracellular membraneless organelle#GO:0043232;supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875 microtubule or microtubule-binding cytoskeletal protein#PC00157 Huntington disease#P00029>Dynein complex#P00774 HUMAN|HGNC=33816|UniProtKB=Q68D42 Q68D42 TMEM215 PTHR31922:SF2 TRANSMEMBRANE PROTEIN 215 TRANSMEMBRANE PROTEIN 215 HUMAN|HGNC=23379|UniProtKB=Q9H756 Q9H756 LRRC19 PTHR31450:SF4 LEUCINE-RICH REPEAT-CONTAINING PROTEIN 19 LRRC19 FAMILY MEMBER LEUCINE-RICH REPEAT-CONTAINING PROTEIN 19 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 positive regulation of response to external stimulus#GO:0032103;immune response-activating signaling pathway#GO:0002757;regulation of response to external stimulus#GO:0032101;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;activation of immune response#GO:0002253;positive regulation of immune system process#GO:0002684;positive regulation of non-canonical NF-kappaB signal transduction#GO:1901224;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;immune system process#GO:0002376;signaling#GO:0023052;response to stimulus#GO:0050896;immune response-regulating signaling pathway#GO:0002764;regulation of biological process#GO:0050789;regulation of non-canonical NF-kappaB signal transduction#GO:1901222;toll-like receptor signaling pathway#GO:0002224;pattern recognition receptor signaling pathway#GO:0002221;positive regulation of response to biotic stimulus#GO:0002833;regulation of innate immune response#GO:0045088;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of defense response#GO:0031349;positive regulation of immune response#GO:0050778;regulation of response to stress#GO:0080134;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of response to stimulus#GO:0048584;positive regulation of innate immune response#GO:0045089;positive regulation of cellular process#GO:0048522;activation of innate immune response#GO:0002218;cell communication#GO:0007154;regulation of defense response#GO:0031347;regulation of immune response#GO:0050776;regulation of response to biotic stimulus#GO:0002831;regulation of cell communication#GO:0010646;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;innate immune response-activating signaling pathway#GO:0002758 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 HUMAN|HGNC=28721|UniProtKB=Q96D59 Q96D59 RNF183 PTHR22791:SF7 RING-TYPE DOMAIN-CONTAINING PROTEIN E3 UBIQUITIN-PROTEIN LIGASE RNF183 ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824 positive regulation of response to stimulus#GO:0048584;post-translational protein modification#GO:0043687;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of cellular process#GO:0048522;macromolecule metabolic process#GO:0043170;regulation of response to stress#GO:0080134;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;positive regulation of apoptotic signaling pathway#GO:2001235;protein modification process#GO:0036211;primary metabolic process#GO:0044238;positive regulation of signal transduction#GO:0009967;regulation of intrinsic apoptotic signaling pathway#GO:2001242;cellular response to stimulus#GO:0051716;regulation of response to endoplasmic reticulum stress#GO:1905897;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;response to endoplasmic reticulum stress#GO:0034976;regulation of apoptotic signaling pathway#GO:2001233;protein ubiquitination#GO:0016567;response to stress#GO:0006950;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of apoptotic process#GO:0043065;metabolic process#GO:0008152;regulation of apoptotic process#GO:0042981;positive regulation of programmed cell death#GO:0043068;response to stimulus#GO:0050896;regulation of programmed cell death#GO:0043067;regulation of biological process#GO:0050789;protein modification by small protein conjugation#GO:0032446;positive regulation of signaling#GO:0023056;regulation of cellular response to stress#GO:0080135;regulation of intracellular signal transduction#GO:1902531;protein modification by small protein conjugation or removal#GO:0070647;regulation of signaling#GO:0023051;cellular response to stress#GO:0033554 organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;endoplasmic reticulum membrane#GO:0005789;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=5384|UniProtKB=P50213 P50213 IDH3A PTHR11835:SF34 DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491 alcohol metabolic process#GO:0006066;carboxylic acid metabolic process#GO:0019752;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;cellular process#GO:0009987;small molecule metabolic process#GO:0044281;secondary alcohol metabolic process#GO:1902652 oxidoreductase#PC00176;dehydrogenase#PC00092 Leucine biosynthesis#P02749>3-Isopropylmalate dehydrogenase#P03001 HUMAN|HGNC=579|UniProtKB=Q99767 Q99767 APBA2 PTHR12345:SF12 SYNTENIN RELATED AMYLOID-BETA A4 PRECURSOR PROTEIN-BINDING FAMILY A MEMBER 2 peptide binding#GO:0042277;binding#GO:0005488 trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;synaptic signaling#GO:0099536;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;cellular process#GO:0009987;anterograde trans-synaptic signaling#GO:0098916;signaling#GO:0023052;biological regulation#GO:0065007;cell-cell signaling#GO:0007267 synapse#GO:0045202;cellular anatomical structure#GO:0110165;neuron spine#GO:0044309;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;postsynapse#GO:0098794;dendritic spine#GO:0043197;intracellular anatomical structure#GO:0005622;dendrite#GO:0030425;dendritic tree#GO:0097447;cytoplasm#GO:0005737;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005;cell junction#GO:0030054 membrane traffic protein#PC00150;membrane trafficking regulatory protein#PC00151 Alzheimer disease-amyloid secretase pathway#P00003>Tip60#P00093;Alzheimer disease-amyloid secretase pathway#P00003>X11alpha#P00084 HUMAN|HGNC=18522|UniProtKB=Q5VV16 Q5VV16 FOXD4L5 PTHR11829:SF420 FORKHEAD BOX PROTEIN FORKHEAD BOX PROTEIN D4-LIKE 3-RELATED sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;developmental process#GO:0032502;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 winged helix/forkhead transcription factor#PC00246;gene-specific transcriptional regulator#PC00264;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=949|UniProtKB=Q16611 Q16611 BAK1 PTHR11256:SF59 BCL-2 RELATED BCL-2 HOMOLOGOUS ANTAGONIST_KILLER channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 negative regulation of apoptotic process#GO:0043066;biological regulation#GO:0065007;positive regulation of cellular process#GO:0048522;apoptotic signaling pathway#GO:0097190;negative regulation of cellular process#GO:0048523;DNA damage response#GO:0006974;regulation of cellular process#GO:0050794;programmed cell death#GO:0012501;cellular response to stimulus#GO:0051716;cell death#GO:0008219;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;mitochondrion organization#GO:0007005;apoptotic mitochondrial changes#GO:0008637;organelle organization#GO:0006996;intrinsic apoptotic signaling pathway in response to DNA damage#GO:0008630;response to stress#GO:0006950;positive regulation of biological process#GO:0048518;negative regulation of programmed cell death#GO:0043069;signal transduction#GO:0007165;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;positive regulation of apoptotic process#GO:0043065;regulation of apoptotic process#GO:0042981;cell surface receptor signaling pathway#GO:0007166;extrinsic apoptotic signaling pathway#GO:0097191;response to stimulus#GO:0050896;release of cytochrome c from mitochondria#GO:0001836;positive regulation of programmed cell death#GO:0043068;signaling#GO:0023052;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;apoptotic process#GO:0006915;intrinsic apoptotic signaling pathway#GO:0097193;cellular response to stress#GO:0033554 organelle outer membrane#GO:0031968;cytoplasm#GO:0005737;membrane#GO:0016020;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;mitochondrial outer membrane#GO:0005741;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;outer membrane#GO:0019867 Apoptosis signaling pathway#P00006>Bak#P00275 HUMAN|HGNC=29856|UniProtKB=Q9GZU8 Q9GZU8 PSME3IP1 PTHR13495:SF0 NEFA-INTERACTING NUCLEAR PROTEIN NIP30 PSME3-INTERACTING PROTEIN membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=19769|UniProtKB=Q8WXJ9 Q8WXJ9 ASB17 PTHR20966:SF2 ANKYRIN REPEAT AND SOCS BOX PROTEIN 17 ANKYRIN REPEAT AND SOCS BOX PROTEIN 17 catabolic process#GO:0009056;positive regulation of programmed cell death#GO:0043068;regulation of cellular process#GO:0050794;regulation of programmed cell death#GO:0043067;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;regulation of biological process#GO:0050789;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;biological regulation#GO:0065007;proteasomal protein catabolic process#GO:0010498;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;positive regulation of apoptotic process#GO:0043065;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;regulation of apoptotic process#GO:0042981 HUMAN|HGNC=2853|UniProtKB=P49619 P49619 DGKG PTHR11255:SF36 DIACYLGLYCEROL KINASE DIACYLGLYCEROL KINASE GAMMA transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;lipid kinase activity#GO:0001727;phosphotransferase activity, alcohol group as acceptor#GO:0016773 neutral lipid metabolic process#GO:0006638;metabolic process#GO:0008152;acylglycerol metabolic process#GO:0006639;glycerophospholipid biosynthetic process#GO:0046474;lipid metabolic process#GO:0006629;glycerophospholipid metabolic process#GO:0006650;lipid biosynthetic process#GO:0008610;biological regulation#GO:0065007;biosynthetic process#GO:0009058;organophosphate metabolic process#GO:0019637;signal transduction#GO:0007165;glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987;cell communication#GO:0007154;organophosphate biosynthetic process#GO:0090407;intracellular signal transduction#GO:0035556;glycerolipid metabolic process#GO:0046486;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;phospholipid biosynthetic process#GO:0008654;signaling#GO:0023052;phospholipid metabolic process#GO:0006644;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 metabolite interconversion enzyme#PC00262;kinase#PC00137 HUMAN|HGNC=17354|UniProtKB=Q96AK3 Q96AK3 APOBEC3D PTHR13857:SF24 MRNA EDITING ENZYME DNA DC-DU-EDITING ENZYME APOBEC-3D binding#GO:0005488;nucleic acid binding#GO:0003676;hydrolase activity#GO:0016787;RNA binding#GO:0003723;catalytic activity#GO:0003824;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;deaminase activity#GO:0019239 response to external biotic stimulus#GO:0043207;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;nucleic acid metabolic process#GO:0090304;cytidine to uridine editing#GO:0016554;primary metabolic process#GO:0044238;regulation of RNA metabolic process#GO:0051252;macromolecule modification#GO:0043412;response to virus#GO:0009615;response to other organism#GO:0051707;regulation of RNA biosynthetic process#GO:2001141;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;defense response#GO:0006952;response to external stimulus#GO:0009605;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;negative regulation of cellular process#GO:0048523;biological process involved in interspecies interaction between organisms#GO:0044419;negative regulation of metabolic process#GO:0009892;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;defense response to virus#GO:0051607;negative regulation of biological process#GO:0048519;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;base conversion or substitution editing#GO:0016553;RNA metabolic process#GO:0016070;RNA modification#GO:0009451;cellular process#GO:0009987;response to stress#GO:0006950;negative regulation of macromolecule biosynthetic process#GO:0010558;response to biotic stimulus#GO:0009607;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;DNA metabolic process#GO:0006259;metabolic process#GO:0008152 intracellular organelle#GO:0043229;P-body#GO:0000932;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;nucleus#GO:0005634;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;ribonucleoprotein granule#GO:0035770;organelle#GO:0043226;supramolecular complex#GO:0099080;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165 RNA processing factor#PC00147 HUMAN|HGNC=20646|UniProtKB=Q8TAU3 Q8TAU3 ZNF417 PTHR24377:SF655 IP01015P-RELATED ZINC FINGER PROTEIN 417-RELATED RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=9196|UniProtKB=P36954 P36954 POLR2I PTHR11239:SF1 DNA-DIRECTED RNA POLYMERASE DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB9 catalytic activity, acting on a nucleic acid#GO:0140640;nucleotidyltransferase activity#GO:0016779;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on RNA#GO:0140098 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;response to stress#GO:0006950;DNA-templated transcription elongation#GO:0006354;transcription initiation at RNA polymerase II promoter#GO:0006367;nucleobase-containing compound metabolic process#GO:0006139;nucleotide-excision repair#GO:0006289;biosynthetic process#GO:0009058;gene expression#GO:0010467;transcription elongation by RNA polymerase II#GO:0006368;transcription by RNA polymerase II#GO:0006366;DNA damage response#GO:0006974;nucleobase-containing compound biosynthetic process#GO:0034654;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;macromolecule metabolic process#GO:0043170;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;DNA-templated transcription initiation#GO:0006352;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070 transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;RNA polymerase II, holoenzyme#GO:0016591;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;nucleoplasm#GO:0005654;RNA polymerase II, core complex#GO:0005665;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;membrane-enclosed lumen#GO:0031974;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;protein-containing complex#GO:0032991 DNA-directed RNA polymerase#PC00019 Transcription regulation by bZIP transcription factor#P00055>RNA Polymerase II#P01388 HUMAN|HGNC=20984|UniProtKB=Q6QNY1 Q6QNY1 BLOC1S2 PTHR46479:SF1 BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 2 BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 2 binding#GO:0005488;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515 cellular process#GO:0009987;lysosome localization#GO:0032418;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;organelle localization#GO:0051640;transport#GO:0006810;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;endosomal transport#GO:0016197 microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;BLOC-1 complex#GO:0031083;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;microtubule cytoskeleton#GO:0015630;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232 HUMAN|HGNC=17136|UniProtKB=Q8IY81 Q8IY81 FTSJ3 PTHR10920:SF13 RIBOSOMAL RNA METHYLTRANSFERASE PRE-RRNA 2'-O-RIBOSE RNA METHYLTRANSFERASE FTSJ3 rRNA (guanine) methyltransferase activity#GO:0016435;rRNA methyltransferase activity#GO:0008649;RNA methyltransferase activity#GO:0008173;catalytic activity, acting on RNA#GO:0140098;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a rRNA#GO:0140102;O-methyltransferase activity#GO:0008171;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757 maturation of LSU-rRNA#GO:0000470;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;rRNA metabolic process#GO:0016072;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;macromolecule modification#GO:0043412;RNA methylation#GO:0001510;rRNA processing#GO:0006364;gene expression#GO:0010467;RNA processing#GO:0006396;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;rRNA methylation#GO:0031167;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;maturation of 5.8S rRNA#GO:0000460;ribonucleoprotein complex biogenesis#GO:0022613;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;rRNA modification#GO:0000154;RNA metabolic process#GO:0016070;methylation#GO:0032259;ribosomal large subunit biogenesis#GO:0042273;ribosome biogenesis#GO:0042254;macromolecule methylation#GO:0043414;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451 nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;membraneless organelle#GO:0043228;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular organelle#GO:0043229;nucleolus#GO:0005730;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;preribosome#GO:0030684;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;preribosome, large subunit precursor#GO:0030687 RNA methyltransferase#PC00033 HUMAN|HGNC=14462|UniProtKB=Q9UGV2 Q9UGV2 NDRG3 PTHR11034:SF20 N-MYC DOWNSTREAM REGULATED PROTEIN NDRG3 cell communication#GO:0007154;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 serine protease#PC00203 HUMAN|Ensembl=ENSG00000282150.1|UniProtKB=A0A0J9YY99 A0A0J9YY99 PTHR23266:SF241 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 3-30-RELATED antigen binding#GO:0003823;binding#GO:0005488 immune response#GO:0006955;adaptive immune response#GO:0002250;response to stimulus#GO:0050896;immune effector process#GO:0002252;immune system process#GO:0002376;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=12408|UniProtKB=P0DPH7 P0DPH7 TUBA3C PTHR11588:SF322 TUBULIN TUBULIN ALPHA-3C CHAIN-RELATED ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;nucleotide binding#GO:0000166;structural molecule activity#GO:0005198;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;guanyl nucleotide binding#GO:0019001;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;structural constituent of cytoskeleton#GO:0005200;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076 microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;mitotic cell cycle#GO:0000278;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;cell cycle#GO:0007049;organelle organization#GO:0006996;cellular process#GO:0009987 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;microtubule#GO:0005874;microtubule cytoskeleton#GO:0015630;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;organelle#GO:0043226;supramolecular complex#GO:0099080 tubulin#PC00228;cytoskeletal protein#PC00085 HUMAN|HGNC=17537|UniProtKB=Q9NY37 Q9NY37 ASIC5 PTHR11690:SF286 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED BILE ACID-SENSITIVE ION CHANNEL ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;sodium channel activity#GO:0005272;ligand-gated monoatomic cation channel activity#GO:0099094;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261 sodium ion transport#GO:0006814;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;transport#GO:0006810;monoatomic ion transport#GO:0006811;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133;transporter#PC00227 HUMAN|HGNC=17582|UniProtKB=Q8WYB5 Q8WYB5 KAT6B PTHR10615:SF73 HISTONE ACETYLTRANSFERASE HISTONE ACETYLTRANSFERASE KAT6B acetyltransferase activity#GO:0016407;binding#GO:0005488;transcription regulator activity#GO:0140110;protein N-acyltransferase activity#GO:0140186;histone modifying activity#GO:0140993;transferase activity#GO:0016740;protein N-acetyltransferase activity#GO:0034212;acyltransferase activity#GO:0016746;protein-lysine-acetyltransferase activity#GO:0061733;chromatin binding#GO:0003682;N-acetyltransferase activity#GO:0008080;histone acetyltransferase activity#GO:0004402;transcription coregulator activity#GO:0003712;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 chromosome#GO:0005694;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;protein acetyltransferase complex#GO:0031248;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;acetyltransferase complex#GO:1902493;membrane-bounded organelle#GO:0043227;chromatin#GO:0000785;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;transferase complex#GO:1990234;membraneless organelle#GO:0043228;intracellular protein-containing complex#GO:0140535;histone acetyltransferase complex#GO:0000123 chromatin/chromatin-binding, or -regulatory protein#PC00077;histone modifying enzyme#PC00261 p53 pathway#P00059>CBP#P04623 HUMAN|Ensembl=ENSG00000266286.3|UniProtKB=A0A140TA64 A0A140TA64 LOC100996750 PTHR23262:SF183 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 4-11-RELATED multicellular organismal process#GO:0032501 structural protein#PC00211 HUMAN|HGNC=435|UniProtKB=P09917 P09917 ALOX5 PTHR11771:SF5 LIPOXYGENASE POLYUNSATURATED FATTY ACID 5-LIPOXYGENASE catalytic activity#GO:0003824;oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen#GO:0016702;oxidoreductase activity#GO:0016491;dioxygenase activity#GO:0051213 lipid oxidation#GO:0034440;oxoacid metabolic process#GO:0043436;olefinic compound metabolic process#GO:0120254;small molecule metabolic process#GO:0044281;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;arachidonate metabolic process#GO:0019369;lipid modification#GO:0030258;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;unsaturated fatty acid metabolic process#GO:0033559;lipid metabolic process#GO:0006629;icosanoid metabolic process#GO:0006690;long-chain fatty acid metabolic process#GO:0001676;cellular process#GO:0009987 nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;nucleus#GO:0005634;organelle envelope#GO:0031967;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 oxidoreductase#PC00176;oxygenase#PC00177 HUMAN|HGNC=21590|UniProtKB=Q7Z5A8 Q7Z5A8 TAFA3 PTHR31770:SF3 CHEMOKINE-LIKE PROTEIN TAFA FAMILY MEMBER CHEMOKINE-LIKE PROTEIN TAFA-3 molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545 negative regulation of cell activation#GO:0050866;positive regulation of defense response#GO:0031349;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;regulation of response to stress#GO:0080134;negative regulation of immune system process#GO:0002683;biological regulation#GO:0065007;positive regulation of cell activation#GO:0050867;positive regulation of response to stimulus#GO:0048584;negative regulation of response to stimulus#GO:0048585;positive regulation of cellular process#GO:0048522;regulation of inflammatory response#GO:0050727;regulation of defense response#GO:0031347;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;negative regulation of inflammatory response#GO:0050728;negative regulation of defense response#GO:0031348;negative regulation of multicellular organismal process#GO:0051241;positive regulation of response to external stimulus#GO:0032103;positive regulation of leukocyte activation#GO:0002696;positive regulation of inflammatory response#GO:0050729;negative regulation of response to external stimulus#GO:0032102;negative regulation of leukocyte activation#GO:0002695;regulation of multicellular organismal process#GO:0051239;regulation of response to external stimulus#GO:0032101;positive regulation of biological process#GO:0048518;regulation of macrophage activation#GO:0043030;positive regulation of immune system process#GO:0002684;regulation of biological process#GO:0050789;regulation of cell activation#GO:0050865;positive regulation of multicellular organismal process#GO:0051240;negative regulation of biological process#GO:0048519;regulation of leukocyte activation#GO:0002694 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 cytokine#PC00083;chemokine#PC00074 HUMAN|HGNC=14105|UniProtKB=Q99932 Q99932 SPAG8 PTHR15510:SF5 SPERM-ASSOCIATED ANTIGEN 8 SPERM-ASSOCIATED ANTIGEN 8 flagellated sperm motility#GO:0030317;cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;cilium-dependent cell motility#GO:0060285;microtubule-based process#GO:0007017;cilium movement involved in cell motility#GO:0060294;sperm motility#GO:0097722;cellular process#GO:0009987;cell motility#GO:0048870;microtubule-based movement#GO:0007018;reproductive process#GO:0022414 cilium#GO:0005929;intracellular organelle#GO:0043229;axoneme#GO:0005930;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membrane-bounded organelle#GO:0043227;cytoplasmic microtubule#GO:0005881;axonemal microtubule#GO:0005879;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cytoskeleton#GO:0005856;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;supramolecular polymer#GO:0099081;ciliary plasm#GO:0097014;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232 HUMAN|HGNC=16468|UniProtKB=P83111 P83111 LACTB PTHR46520:SF1 SERINE BETA-LACTAMASE-LIKE PROTEIN LACTB, MITOCHONDRIAL SERINE BETA-LACTAMASE-LIKE PROTEIN LACTB, MITOCHONDRIAL catalytic activity#GO:0003824;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;proteolysis#GO:0006508;metabolic process#GO:0008152;regulation of lipid metabolic process#GO:0019216;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;cellular process#GO:0009987 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|Ensembl=ENSG00000285408.1|UniProtKB=A0A2R8YFR7 A0A2R8YFR7 LOC107987545 PTHR12845:SF2 GUANINE NUCLEOTIDE EXCHANGE FACTOR DH DOMAIN-CONTAINING PROTEIN-RELATED molecular function regulator activity#GO:0098772;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;guanyl-nucleotide exchange factor activity#GO:0005085 regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of actin cytoskeleton organization#GO:0032956;regulation of actin filament-based process#GO:0032970 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 guanyl-nucleotide exchange factor#PC00113;protein-binding activity modulator#PC00095;G-protein modulator#PC00022 HUMAN|HGNC=14460|UniProtKB=Q9UN36 Q9UN36 NDRG2 PTHR11034:SF17 N-MYC DOWNSTREAM REGULATED PROTEIN NDRG2 cell communication#GO:0007154;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 serine protease#PC00203 HUMAN|HGNC=604|UniProtKB=P41238 P41238 APOBEC1 PTHR13857:SF26 MRNA EDITING ENZYME C-U-EDITING ENZYME APOBEC-1 hydrolase activity#GO:0016787;RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;deaminase activity#GO:0019239;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;catalytic activity#GO:0003824 RNA modification#GO:0009451;metabolic process#GO:0008152;base conversion or substitution editing#GO:0016553;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;cytidine to uridine editing#GO:0016554;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;nucleobase-containing compound metabolic process#GO:0006139 nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 RNA processing factor#PC00147 HUMAN|HGNC=10806|UniProtKB=Q16585 Q16585 SGCB PTHR21142:SF2 SARCOGLYCANS BETA-SARCOGLYCAN plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane#GO:0016020;dystrophin-associated glycoprotein complex#GO:0016010;membrane protein complex#GO:0098796;sarcolemma#GO:0042383 non-motor actin binding protein#PC00165 HUMAN|HGNC=24861|UniProtKB=Q9BUM1 Q9BUM1 G6PC3 PTHR12591:SF2 GLUCOSE-6-PHOSPHATASE GLUCOSE-6-PHOSPHATASE 3 hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;sugar-phosphatase activity#GO:0050308;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 carbohydrate biosynthetic process#GO:0016051;biosynthetic process#GO:0009058;carbohydrate metabolic process#GO:0005975;monosaccharide biosynthetic process#GO:0046364;small molecule metabolic process#GO:0044281;cellular process#GO:0009987;gluconeogenesis#GO:0006094;hexose biosynthetic process#GO:0019319;hexose metabolic process#GO:0019318;primary metabolic process#GO:0044238;glucose metabolic process#GO:0006006;small molecule biosynthetic process#GO:0044283;monosaccharide metabolic process#GO:0005996;metabolic process#GO:0008152 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 phosphatase#PC00181;hydrolase#PC00121 HUMAN|HGNC=30200|UniProtKB=Q2TAL6 Q2TAL6 VWC2 PTHR46252:SF4 BRORIN FAMILY MEMBER BRORIN regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092;negative regulation of cell communication#GO:0010648;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;negative regulation of signal transduction#GO:0009968;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cellular response to growth factor stimulus#GO:0090287;negative regulation of response to stimulus#GO:0048585;regulation of BMP signaling pathway#GO:0030510;negative regulation of BMP signaling pathway#GO:0030514;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;plasma membrane#GO:0005886;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;signaling receptor complex#GO:0043235;extracellular region#GO:0005576 HUMAN|HGNC=17307|UniProtKB=O14981 O14981 BTAF1 PTHR36498:SF1 TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172 TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172 HUMAN|HGNC=5837|UniProtKB=A0A0A0MT36 A0A0A0MT36 IGKV6D-21 PTHR23267:SF528 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN KAPPA VARIABLE 6-21-RELATED response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=5118|UniProtKB=P09629 P09629 HOXB7 PTHR45659:SF11 HOMEOBOX PROTEIN HOX HOMEOBOX PROTEIN HOX-B7 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;pattern specification process#GO:0007389;multicellular organismal process#GO:0032501;regionalization#GO:0003002;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biosynthetic process#GO:0009889;multicellular organism development#GO:0007275;regulation of gene expression#GO:0010468;anterior/posterior pattern specification#GO:0009952;developmental process#GO:0032502 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119 HUMAN|HGNC=7644|UniProtKB=P49321 P49321 NASP PTHR15081:SF1 NUCLEAR AUTOANTIGENIC SPERM PROTEIN NASP -RELATED NUCLEAR AUTOANTIGENIC SPERM PROTEIN histone binding#GO:0042393;binding#GO:0005488;protein binding#GO:0005515 organelle assembly#GO:0070925;kinetochore assembly#GO:0051382;cellular component organization or biogenesis#GO:0071840;kinetochore organization#GO:0051383;protein-containing complex organization#GO:0043933;chromosome organization#GO:0051276;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;cellular component assembly#GO:0022607;chromatin organization#GO:0006325 nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 chaperone#PC00072 HUMAN|HGNC=18943|UniProtKB=Q3LI63 Q3LI63 KRTAP20-1 PTHR39653:SF6 KERATIN-ASSOCIATED PROTEIN 20-2 KERATIN-ASSOCIATED PROTEIN 20-1 structural protein#PC00211 HUMAN|HGNC=34|UniProtKB=P78363 P78363 ABCA4 PTHR19229:SF190 ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA RETINAL-SPECIFIC PHOSPHOLIPID-TRANSPORTING ATPASE ABCA4 intramembrane lipid carrier activity#GO:0140303;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626;molecular carrier activity#GO:0140104;lipid carrier activity#GO:0005319;active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399;ATPase-coupled intramembrane lipid carrier activity#GO:0140326;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 lipid localization#GO:0010876;macromolecule localization#GO:0033036;transport#GO:0006810;localization#GO:0051179;lipid transport#GO:0006869;establishment of localization#GO:0051234 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 ATP-binding cassette (ABC) transporter#PC00003 HUMAN|HGNC=12227|UniProtKB=A0A0J9YXY3 A0A0J9YXY3 TRBV6-2 PTHR23268:SF19 T-CELL RECEPTOR BETA CHAIN T CELL RECEPTOR BETA VARIABLE 6-2-RELATED regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=7686|UniProtKB=O95167 O95167 NDUFA3 PTHR15221:SF0 NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 3 NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 3 transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;respiratory chain complex I#GO:0045271;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;respiratory chain complex#GO:0098803;oxidoreductase complex#GO:1990204;membrane#GO:0016020;membrane protein complex#GO:0098796 dehydrogenase#PC00092 HUMAN|HGNC=34397|UniProtKB=P0C870 P0C870 JMJD7 PTHR12461:SF99 HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED BIFUNCTIONAL PEPTIDASE AND (3S)-LYSYL HYDROXYLASE JMJD7 peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;oxidoreductase activity#GO:0016491;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824;dioxygenase activity#GO:0051213;hydrolase activity#GO:0016787 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260 HUMAN|HGNC=6664|UniProtKB=P28300 P28300 LOX PTHR45817:SF6 LYSYL OXIDASE-LIKE-RELATED PROTEIN-LYSINE 6-OXIDASE catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;catalytic activity, acting on a protein#GO:0140096 cell surface receptor signaling pathway#GO:0007166;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;signal transduction#GO:0007165;biological regulation#GO:0065007;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;collagen fibril organization#GO:0030199;enzyme-linked receptor protein signaling pathway#GO:0007167;extracellular matrix organization#GO:0030198;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 oxidoreductase#PC00176;oxidase#PC00175 HUMAN|HGNC=10861|UniProtKB=Q96JF0 Q96JF0 ST6GAL2 PTHR46059:SF3 BETA-GALACTOSIDE ALPHA-2,6-SIALYLTRANSFERASE BETA-GALACTOSIDE ALPHA-2,6-SIALYLTRANSFERASE 2 sialyltransferase activity#GO:0008373;glycosyltransferase activity#GO:0016757;transferase activity#GO:0016740;catalytic activity#GO:0003824 macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;cellular process#GO:0009987 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226 transferase#PC00220;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=20517|UniProtKB=Q6DRA6 Q6DRA6 H2BC19P PTHR23428:SF298 HISTONE H2B HISTONE H2B TYPE 2-C-RELATED response to stimulus#GO:0050896;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to bacterium#GO:0009617;immune system process#GO:0002376;defense response to bacterium#GO:0042742;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;defense response to symbiont#GO:0140546;immune response#GO:0006955;defense response to other organism#GO:0098542;response to other organism#GO:0051707;antimicrobial humoral response#GO:0019730;humoral immune response#GO:0006959;antibacterial humoral response#GO:0019731;innate immune response#GO:0045087;response to external stimulus#GO:0009605;defense response#GO:0006952 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=11967|UniProtKB=Q5SZQ8 Q5SZQ8 CELF3 PTHR24012:SF739 RNA BINDING PROTEIN CUGBP ELAV-LIKE FAMILY MEMBER 3 mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 regulation of RNA splicing#GO:0043484;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;biosynthetic process#GO:0009058;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of mRNA processing#GO:0050684;macromolecule biosynthetic process#GO:0009059;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;RNA biosynthetic process#GO:0032774;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of mRNA splicing, via spliceosome#GO:0048024;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of RNA metabolic process#GO:0051252;protein-RNA complex assembly#GO:0022618;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA splicing, via transesterification reactions#GO:0000375;RNA processing#GO:0006396;mRNA splice site recognition#GO:0006376;cellular component assembly#GO:0022607;gene expression#GO:0010467;cellular process#GO:0009987;mRNA processing#GO:0006397;cellular component biogenesis#GO:0044085;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;regulation of mRNA metabolic process#GO:1903311;protein-RNA complex organization#GO:0071826;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;mRNA metabolic process#GO:0016071;ribonucleoprotein complex biogenesis#GO:0022613;regulation of biological process#GO:0050789;protein-containing complex assembly#GO:0065003;mRNA splicing, via spliceosome#GO:0000398;cellular component organization#GO:0016043;regulation of alternative mRNA splicing, via spliceosome#GO:0000381;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;spliceosomal complex assembly#GO:0000245 ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 RNA metabolism protein#PC00031 HUMAN|HGNC=18712|UniProtKB=Q8N135 Q8N135 LGI4 PTHR24367:SF268 LEUCINE-RICH REPEAT-CONTAINING PROTEIN LEUCINE-RICH REPEAT LGI FAMILY MEMBER 4 cell development#GO:0048468;cell differentiation#GO:0030154;anatomical structure maturation#GO:0071695;peripheral nervous system development#GO:0007422;neuron development#GO:0048666;system development#GO:0048731;anatomical structure development#GO:0048856;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;nervous system development#GO:0007399;glial cell differentiation#GO:0010001;multicellular organismal process#GO:0032501;developmental maturation#GO:0021700;cellular process#GO:0009987;myelination#GO:0042552;neurogenesis#GO:0022008;gliogenesis#GO:0042063;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;cell maturation#GO:0048469;neuron differentiation#GO:0030182;developmental process#GO:0032502 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=15844|UniProtKB=Q9NQG7 Q9NQG7 HPS4 PTHR14407:SF9 HERMANSKY-PUDLAK SYNDROME 4 PROTEIN LIGHT-EAR PROTEIN-RELATED BLOC-3 COMPLEX MEMBER HPS4 guanyl-nucleotide exchange factor activity#GO:0005085;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function regulator activity#GO:0098772 vesicle organization#GO:0016050;cellular component organization or biogenesis#GO:0071840;localization#GO:0051179;establishment of localization#GO:0051234;melanosome organization#GO:0032438;pigmentation#GO:0043473;organelle assembly#GO:0070925;cellular pigmentation#GO:0033059;cellular component assembly#GO:0022607;protein targeting#GO:0006605;establishment of protein localization#GO:0045184;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043 vacuole#GO:0005773;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;lysosomal membrane#GO:0005765;membrane#GO:0016020;intracellular protein-containing complex#GO:0140535;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;lytic vacuole#GO:0000323;vacuolar membrane#GO:0005774;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;lysosome#GO:0005764;lytic vacuole membrane#GO:0098852;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=7188|UniProtKB=Q99583 Q99583 MNT PTHR11969:SF99 MAX DIMERIZATION, MAD MAX-BINDING PROTEIN MNT sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 gene-specific transcriptional regulator#PC00264;basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=25740|UniProtKB=Q5JTW2 Q5JTW2 CEP78 PTHR24110:SF3 CENTROSOMAL PROTEIN OF 78 KDA CENTROSOMAL PROTEIN OF 78 KDA cilium organization#GO:0044782;plasma membrane bounded cell projection organization#GO:0120036;cell projection organization#GO:0030030;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996 microtubule cytoskeleton#GO:0015630;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cilium#GO:0005929;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;centrosome#GO:0005813;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228 HUMAN|HGNC=6612|UniProtKB=Q9UGP4 Q9UGP4 LIMD1 PTHR24219:SF3 LIM DOMAIN-CONTAINING PROTEIN JUB LIM DOMAIN-CONTAINING PROTEIN 1 transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of signaling#GO:0023051;negative regulation of translation#GO:0017148;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of hippo signaling#GO:0035331;negative regulation of DNA-templated transcription#GO:0045892;regulation of biological process#GO:0050789;miRNA-mediated post-transcriptional gene silencing#GO:0035195;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of hippo signaling#GO:0035330;negative regulation of metabolic process#GO:0009892;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of protein metabolic process#GO:0051246;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of signal transduction#GO:0009968;post-transcriptional gene silencing#GO:0016441;regulatory ncRNA-mediated post-transcriptional gene silencing#GO:0035194;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;negative regulation of protein metabolic process#GO:0051248;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of response to stimulus#GO:0048583;regulatory ncRNA-mediated gene silencing#GO:0031047;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;regulation of signal transduction#GO:0009966;negative regulation of response to stimulus#GO:0048585;regulation of nucleobase-containing compound metabolic process#GO:0019219 anchoring junction#GO:0070161;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;P-body#GO:0000932;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;membraneless organelle#GO:0043228;cell junction#GO:0030054;adherens junction#GO:0005912;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cell-cell junction#GO:0005911;nucleus#GO:0005634 transcription cofactor#PC00217;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=17452|UniProtKB=Q9HBK9 Q9HBK9 AS3MT PTHR43675:SF37 ARSENITE METHYLTRANSFERASE ARSENITE METHYLTRANSFERASE transferase activity#GO:0016740;catalytic activity#GO:0003824;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741 secondary metabolic process#GO:0019748;cellular response to chemical stimulus#GO:0070887;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;response to xenobiotic stimulus#GO:0009410;cellular response to xenobiotic stimulus#GO:0071466;xenobiotic metabolic process#GO:0006805;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;response to chemical#GO:0042221;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;carboxylic acid metabolic process#GO:0019752 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;transferase#PC00220;methyltransferase#PC00155 HUMAN|HGNC=27902|UniProtKB=Q0P5N6 Q0P5N6 ARL16 PTHR46688:SF1 ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 16 ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 16 HUMAN|HGNC=13590|UniProtKB=Q86XK2 Q86XK2 FBXO11 PTHR22990:SF20 F-BOX ONLY PROTEIN F-BOX ONLY PROTEIN 11 enzyme-substrate adaptor activity#GO:0140767;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=17337|UniProtKB=P62502 P62502 LCN6 PTHR11430:SF10 LIPOCALIN EPIDIDYMAL-SPECIFIC LIPOCALIN-6 transfer/carrier protein#PC00219 HUMAN|HGNC=11944|UniProtKB=P02585 P02585 TNNC2 PTHR23064:SF72 TROPONIN TROPONIN C, SKELETAL MUSCLE actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=21315|UniProtKB=Q8IW70 Q8IW70 TMEM151B PTHR31893:SF4 TRANSMEMBRANE PROTEIN 151 HOMOLOG TRANSMEMBRANE PROTEIN 151B cellular anatomical structure#GO:0110165;membrane#GO:0016020 HUMAN|HGNC=29088|UniProtKB=Q29RF7 Q29RF7 PDS5A PTHR12663:SF2 ANDROGEN INDUCED INHIBITOR OF PROLIFERATION AS3 / PDS5-RELATED SISTER CHROMATID COHESION PROTEIN PDS5 HOMOLOG A chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=20974|UniProtKB=Q9HAR2 Q9HAR2 ADGRL3 PTHR12011:SF60 ADHESION G-PROTEIN COUPLED RECEPTOR ADHESION G PROTEIN-COUPLED RECEPTOR L3 signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=1380|UniProtKB=P23280 P23280 CA6 PTHR18952:SF110 CARBONIC ANHYDRASE CARBONIC ANHYDRASE 6 hydro-lyase activity#GO:0016836;carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;catalytic activity#GO:0003824 extracellular region#GO:0005576;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;dehydratase#PC00091 HUMAN|HGNC=1863|UniProtKB=P23141 P23141 CES1 PTHR11559:SF441 CARBOXYLESTERASE LIVER CARBOXYLESTERASE 1-RELATED hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;carboxylic ester hydrolase activity#GO:0052689;catalytic activity#GO:0003824 cellular process#GO:0009987;lipid catabolic process#GO:0016042;carboxylic acid catabolic process#GO:0046395;monocarboxylic acid catabolic process#GO:0072329;lipid metabolic process#GO:0006629;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;monocarboxylic acid metabolic process#GO:0032787;small molecule catabolic process#GO:0044282;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;oxoacid metabolic process#GO:0043436;fatty acid catabolic process#GO:0009062;short-chain fatty acid catabolic process#GO:0019626 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;lipid droplet#GO:0005811;membraneless organelle#GO:0043228;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226 esterase#PC00097 HUMAN|HGNC=32151|UniProtKB=Q5T2N8 Q5T2N8 ATAD3C PTHR23075:SF4 PUTATIVE ATP-ASE ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 3C cellular component organization or biogenesis#GO:0071840;mitochondrion organization#GO:0007005;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=30086|UniProtKB=Q6P1R4 Q6P1R4 DUS1L PTHR11082:SF5 TRNA-DIHYDROURIDINE SYNTHASE TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;oxidoreductase activity#GO:0016491;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 RNA processing factor#PC00147 HUMAN|HGNC=14724|UniProtKB=Q8NGQ5 Q8NGQ5 OR9Q1 PTHR48018:SF60 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 9Q1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 biological regulation#GO:0065007;multicellular organismal process#GO:0032501;cellular process#GO:0009987;signal transduction#GO:0007165;system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606;signaling#GO:0023052;regulation of cellular process#GO:0050794;sensory perception of smell#GO:0007608;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cell communication#GO:0007154;nervous system process#GO:0050877;sensory perception#GO:0007600;G protein-coupled receptor signaling pathway#GO:0007186 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=55922|UniProtKB=A0A494BZU4 A0A494BZU4 TMEM217B PTHR34928:SF3 TRANSMEMBRANE PROTEIN 217 TRANSMEMBRANE PROTEIN 217B HUMAN|HGNC=19168|UniProtKB=Q9GZM7 Q9GZM7 TINAGL1 PTHR12411:SF270 CYSTEINE PROTEASE FAMILY C1-RELATED TUBULOINTERSTITIAL NEPHRITIS ANTIGEN-LIKE hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;cysteine-type endopeptidase activity#GO:0004197;endopeptidase activity#GO:0004175;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;catabolic process#GO:0009056;cellular process#GO:0009987;primary metabolic process#GO:0044238 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;vacuole#GO:0005773;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;extracellular region#GO:0005576;intracellular organelle#GO:0043229 protein modifying enzyme#PC00260;cysteine protease#PC00081;protease#PC00190 HUMAN|HGNC=12926|UniProtKB=Q15928 Q15928 ZNF141 PTHR24384:SF102 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED ZINC FINGER PROTEIN 141 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA-binding transcription factor#PC00218 HUMAN|HGNC=30413|UniProtKB=Q86W33 Q86W33 TPRA1 PTHR15876:SF8 TRANSMEMBRANE PROTEIN ADIPOCYTE-ASSOCIATED 1 TRANSMEMBRANE PROTEIN ADIPOCYTE-ASSOCIATED 1 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HUMAN|HGNC=16252|UniProtKB=Q8TC36 Q8TC36 SUN5 PTHR12911:SF44 SAD1/UNC-84-LIKE PROTEIN-RELATED SUN DOMAIN-CONTAINING PROTEIN 5 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;protein-membrane adaptor activity#GO:0043495 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;membrane#GO:0016020;organelle envelope#GO:0031967;membrane protein complex#GO:0098796 microtubule or microtubule-binding cytoskeletal protein#PC00157;non-motor microtubule binding protein#PC00166;cytoskeletal protein#PC00085 HUMAN|HGNC=40031|UniProtKB=A6NNT2 A6NNT2 C16orf96 PTHR47080:SF1 CHROMOSOME 16 OPEN READING FRAME 96 DUF4795 DOMAIN-CONTAINING PROTEIN HUMAN|HGNC=25955|UniProtKB=Q8ND82 Q8ND82 ZNF280C PTHR24388:SF62 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 280C sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=24663|UniProtKB=Q5R372 Q5R372 RABGAP1L PTHR47219:SF7 RAB GTPASE-ACTIVATING PROTEIN 1-LIKE RAB GTPASE-ACTIVATING PROTEIN 1-LIKE molecular function activator activity#GO:0140677;protein binding#GO:0005515;enzyme regulator activity#GO:0030234;small GTPase binding#GO:0031267;enzyme binding#GO:0019899;binding#GO:0005488;molecular function regulator activity#GO:0098772;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;enzyme activator activity#GO:0008047 regulation of biological process#GO:0050789;biological regulation#GO:0065007;regulation of protein localization#GO:0032880;regulation of localization#GO:0032879 GTPase-activating protein#PC00257;G-protein modulator#PC00022 HUMAN|HGNC=30292|UniProtKB=Q13283 Q13283 G3BP1 PTHR10693:SF21 RAS GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN RAS GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN 1 ATP-dependent activity#GO:0140657;mRNA binding#GO:0003729;binding#GO:0005488;ATP-dependent activity, acting on DNA#GO:0008094;nucleic acid conformation isomerase activity#GO:0120545;RNA helicase activity#GO:0003724;DNA helicase activity#GO:0003678;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on DNA#GO:0140097;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;macromolecular conformation isomerase activity#GO:0120543;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;isomerase activity#GO:0016853;helicase activity#GO:0004386 cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;cellular component assembly#GO:0022607;cytoplasmic stress granule assembly#GO:0034063;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840 cytosol#GO:0005829;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;organelle#GO:0043226;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;cytoplasmic stress granule#GO:0010494;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HUMAN|HGNC=5401|UniProtKB=Q9HB58 Q9HB58 SP110 PTHR46386:SF7 NUCLEAR BODY PROTEIN SP140 SP110 NUCLEAR BODY PROTEIN transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=16366|UniProtKB=Q96PE6 Q96PE6 ZIM3 PTHR24377:SF30 IP01015P-RELATED ZINC FINGER IMPRINTED 3 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=7775|UniProtKB=O95644 O95644 NFATC1 PTHR12533:SF5 NFAT NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 1 DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;signaling#GO:0023052;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of macromolecule metabolic process#GO:0010604;intracellular signaling cassette#GO:0141124;positive regulation of transcription by RNA polymerase II#GO:0045944;calcineurin-mediated signaling#GO:0097720;calcineurin-NFAT signaling cascade#GO:0033173;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;regulation of DNA-templated transcription#GO:0006355;cell communication#GO:0007154;positive regulation of biosynthetic process#GO:0009891;intracellular signal transduction#GO:0035556;regulation of RNA metabolic process#GO:0051252;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;calcium-mediated signaling#GO:0019722 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 gene-specific transcriptional regulator#PC00264;Rel homology transcription factor#PC00252;immunoglobulin fold transcription factor#PC00251 Wnt signaling pathway#P00057>NFAT#P01452;T cell activation#P00053>NFAT#P01294;B cell activation#P00010>NFAT#P00367;Gonadotropin-releasing hormone receptor pathway#P06664>NFAT#P06777;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>NFAT#P00851 HUMAN|HGNC=1168|UniProtKB=Q9NQ34 Q9NQ34 TMEM9B PTHR13064:SF2 TRANSMEMBRANE PROTEIN 9 FAMILY MEMBER TRANSMEMBRANE PROTEIN 9B HUMAN|HGNC=53848|UniProtKB=A0A1W2PP81 A0A1W2PP81 TAF11L5 PTHR13218:SF18 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11-RELATED TATA-BOX-BINDING PROTEIN-ASSOCIATED FACTOR 11-LIKE PROTEIN 10-RELATED nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;DNA-templated transcription initiation#GO:0006352;RNA polymerase II preinitiation complex assembly#GO:0051123;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;transcription by RNA polymerase II#GO:0006366;cellular component organization or biogenesis#GO:0071840;protein-DNA complex organization#GO:0071824;macromolecule metabolic process#GO:0043170;protein-containing complex organization#GO:0043933;cellular component biogenesis#GO:0044085;transcription initiation at RNA polymerase II promoter#GO:0006367;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;cellular component assembly#GO:0022607;protein-DNA complex assembly#GO:0065004;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;membrane-bounded organelle#GO:0043227;RNA polymerase II, holoenzyme#GO:0016591;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;transcription regulator complex#GO:0005667;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;RNA polymerase II transcription regulator complex#GO:0090575;membrane-enclosed lumen#GO:0031974;transcription factor TFIID complex#GO:0005669;protein-containing complex#GO:0032991 RNA metabolism protein#PC00031;general transcription factor#PC00259 HUMAN|HGNC=21717|UniProtKB=P86790 P86790 CCZ1B PTHR13056:SF0 VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;guanyl-nucleotide exchange factor activity#GO:0005085 vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;transport#GO:0006810;vacuolar transport#GO:0007034;intracellular transport#GO:0046907 protein-containing complex#GO:0032991;late endosome#GO:0005770;guanyl-nucleotide exchange factor complex#GO:0032045;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular protein-containing complex#GO:0140535;intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=3987|UniProtKB=Q9BXU8 Q9BXU8 FTHL17 PTHR11431:SF97 FERRITIN FERRITIN HEAVY POLYPEPTIDE-LIKE 17-RELATED iron ion binding#GO:0005506;ferrous iron binding#GO:0008198;cation binding#GO:0043169;metal ion binding#GO:0046872;transition metal ion binding#GO:0046914;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 storage protein#PC00210 HUMAN|HGNC=29095|UniProtKB=O75157 O75157 TSC22D2 PTHR46894:SF1 TSC22 DOMAIN FAMILY PROTEIN 2 TSC22 DOMAIN FAMILY PROTEIN 2 HUMAN|HGNC=9811|UniProtKB=O60216 O60216 RAD21 PTHR12585:SF20 SCC1 / RAD21 FAMILY MEMBER DOUBLE-STRAND-BREAK REPAIR PROTEIN RAD21 HOMOLOG binding#GO:0005488;chromatin binding#GO:0003682 sister chromatid cohesion#GO:0007062;recombinational repair#GO:0000725;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;cell cycle#GO:0007049;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;double-strand break repair via homologous recombination#GO:0000724;cell cycle process#GO:0022402;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;chromosome organization#GO:0051276;double-strand break repair#GO:0006302;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;DNA recombination#GO:0006310;DNA damage response#GO:0006974;nucleobase-containing compound metabolic process#GO:0006139;replication-born double-strand break repair via sister chromatid exchange#GO:1990414;organelle organization#GO:0006996;response to stress#GO:0006950;cellular process#GO:0009987 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cohesin complex#GO:0008278 HUMAN|HGNC=12276|UniProtKB=P03986 P03986 TRGC2 PTHR19256:SF71 T-CELL RECEPTOR GAMMA CHAIN T CELL RECEPTOR GAMMA CONSTANT 1-RELATED immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=3542|UniProtKB=P12259 P12259 F5 PTHR24543:SF302 MULTICOPPER OXIDASE-RELATED COAGULATION FACTOR V circulatory system process#GO:0003013;system process#GO:0003008;regulation of biological quality#GO:0065008;blood coagulation#GO:0007596;wound healing#GO:0042060;hemostasis#GO:0007599;response to wounding#GO:0009611;response to stress#GO:0006950;coagulation#GO:0050817;blood circulation#GO:0008015;response to stimulus#GO:0050896;multicellular organismal process#GO:0032501;regulation of body fluid levels#GO:0050878;biological regulation#GO:0065007 membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;extracellular region#GO:0005576;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;secretory vesicle#GO:0099503 oxidoreductase#PC00176 Blood coagulation#P00011>FVa#P00435;Blood coagulation#P00011>FV#P00432 HUMAN|HGNC=31103|UniProtKB=Q8NHR9 Q8NHR9 PFN4 PTHR11604:SF2 PROFILIN PROFILIN-4 protein binding#GO:0005515;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;actin monomer binding#GO:0003785 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;cell cortex#GO:0005938 non-motor actin binding protein#PC00165;actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=29929|UniProtKB=Q8NFH4 Q8NFH4 NUP37 PTHR22806:SF0 NUCLEOPORIN NUP37 P37 -RELATED NUCLEOPORIN NUP37 nuclear pore outer ring#GO:0031080;nucleus#GO:0005634;organelle envelope#GO:0031967;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear pore#GO:0005643;nuclear protein-containing complex#GO:0140513 transporter#PC00227 HUMAN|HGNC=21573|UniProtKB=Q6NT16 Q6NT16 SLC18B1 PTHR23506:SF44 GH10249P MFS-TYPE TRANSPORTER SLC18B1 monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075;active transmembrane transporter activity#GO:0022804;antiporter activity#GO:0015297;proton transmembrane transporter activity#GO:0015078;secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;monoamine transmembrane transporter activity#GO:0008504;transmembrane transporter activity#GO:0022857 cytoplasm#GO:0005737;transport vesicle#GO:0030133;cytoplasmic vesicle membrane#GO:0030659;transport vesicle membrane#GO:0030658;endomembrane system#GO:0012505;presynapse#GO:0098793;vesicle membrane#GO:0012506;membrane#GO:0016020;secretory vesicle#GO:0099503;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;cell junction#GO:0030054;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;synapse#GO:0045202;synaptic vesicle membrane#GO:0030672;vesicle#GO:0031982;synaptic vesicle#GO:0008021;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382 transporter#PC00227;secondary carrier transporter#PC00258 HUMAN|HGNC=13056|UniProtKB=O14978 O14978 ZNF263 PTHR23226:SF401 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER PROTEIN 263 RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=3609|UniProtKB=P12319 P12319 FCER1A PTHR11481:SF12 IMMUNOGLOBULIN FC RECEPTOR HIGH AFFINITY IMMUNOGLOBULIN EPSILON RECEPTOR SUBUNIT ALPHA signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 immune effector process#GO:0002252;cell surface receptor signaling pathway#GO:0007166;cellular process#GO:0009987;signal transduction#GO:0007165;immune response#GO:0006955;adaptive immune response#GO:0002250;biological regulation#GO:0065007;immune system process#GO:0002376;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449;cell communication#GO:0007154;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052 side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;plasma membrane#GO:0005886;membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=10344|UniProtKB=P42766 P42766 RPL35 PTHR45722:SF37 60S RIBOSOMAL PROTEIN L35 LARGE RIBOSOMAL SUBUNIT PROTEIN UL29 RNA binding#GO:0003723;structural molecule activity#GO:0005198;mRNA binding#GO:0003729;structural constituent of ribosome#GO:0003735;binding#GO:0005488;nucleic acid binding#GO:0003676 metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;gene expression#GO:0010467;maturation of LSU-rRNA#GO:0000470;nucleic acid biosynthetic process#GO:0141187;ribosomal large subunit biogenesis#GO:0042273;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613 ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;ribosome#GO:0005840;cytosol#GO:0005829;cytosolic large ribosomal subunit#GO:0022625;cytosolic ribosome#GO:0022626;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934 ribosomal protein#PC00202 HUMAN|HGNC=10604|UniProtKB=O43819 O43819 SCO2 PTHR12151:SF2 ELECTRON TRANSPORT PROTIN SCO1/SENC FAMILY MEMBER CYTOCHROME C OXIDASE ASSEMBLY FACTOR SCO2 cellular component assembly#GO:0022607;mitochondrion organization#GO:0007005;mitochondrial respiratory chain complex assembly#GO:0033108;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;respiratory chain complex IV assembly#GO:0008535;protein-containing complex organization#GO:0043933;mitochondrial respiratory chain complex IV assembly#GO:0033617;cytochrome complex assembly#GO:0017004 oxidoreductase#PC00176;oxidase#PC00175;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=10887|UniProtKB=Q15475 Q15475 SIX1 PTHR10390:SF13 HOMEOBOX PROTEIN SIX HOMEOBOX PROTEIN SIX1 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 HUMAN|HGNC=15373|UniProtKB=Q8NGB6 Q8NGB6 OR4M2 PTHR48002:SF103 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 4M1-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=12003|UniProtKB=O15350 O15350 TP73 PTHR11447:SF21 CELLULAR TUMOR ANTIGEN P53 TUMOR PROTEIN P73 RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;chromatin binding#GO:0003682;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 positive regulation of macromolecule metabolic process#GO:0010604;intrinsic apoptotic signaling pathway in response to DNA damage#GO:0008630;response to stress#GO:0006950;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of apoptotic process#GO:0042981;intrinsic apoptotic signaling pathway by p53 class mediator#GO:0072332;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;signaling#GO:0023052;regulation of programmed cell death#GO:0043067;regulation of biological process#GO:0050789;apoptotic process#GO:0006915;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;intrinsic apoptotic signaling pathway#GO:0097193;signal transduction by p53 class mediator#GO:0072331;cellular response to stress#GO:0033554;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;regulation of biosynthetic process#GO:0009889;apoptotic signaling pathway#GO:0097190;regulation of gene expression#GO:0010468;DNA damage response#GO:0006974;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;programmed cell death#GO:0012501;intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator#GO:0042771;cell death#GO:0008219;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;intracellular signal transduction#GO:0035556 chromosome#GO:0005694;chromatin#GO:0000785;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 P53-like transcription factor#PC00253;gene-specific transcriptional regulator#PC00264 P53 pathway feedback loops 1#P04392>p73#G04686;p53 pathway by glucose deprivation#P04397>p53#P04640;p53 pathway feedback loops 2#P04398>p53#P04668;P53 pathway feedback loops 1#P04392>p53#P04539;Huntington disease#P00029>p53#P00797;p53 pathway#P00059>p53#P01485;p53 pathway#P00059>p53#G04702 HUMAN|HGNC=2545|UniProtKB=P25774 P25774 CTSS PTHR12411:SF1077 CYSTEINE PROTEASE FAMILY C1-RELATED CATHEPSIN S catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;cysteine-type endopeptidase activity#GO:0004197 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;catabolic process#GO:0009056;cellular process#GO:0009987;primary metabolic process#GO:0044238 intracellular organelle#GO:0043229;extracellular region#GO:0005576;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;vacuole#GO:0005773;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 protease#PC00190;protein modifying enzyme#PC00260;cysteine protease#PC00081 HUMAN|HGNC=5555|UniProtKB=A0A0C4DH39 A0A0C4DH39 IGHV1-58 PTHR23266:SF270 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 1-58 binding#GO:0005488;antigen binding#GO:0003823 lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;immunoglobulin mediated immune response#GO:0016064;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immune system process#GO:0002376;immune effector process#GO:0002252;response to stimulus#GO:0050896;adaptive immune response#GO:0002250;immune response#GO:0006955 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=25199|UniProtKB=Q9BTV6 Q9BTV6 DPH7 PTHR46042:SF1 DIPHTHINE METHYLTRANSFERASE DIPHTHINE METHYLTRANSFERASE macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;cellular process#GO:0009987;metabolic process#GO:0008152;primary metabolic process#GO:0044238;protein modification process#GO:0036211 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 methyltransferase#PC00155 HUMAN|HGNC=2966|UniProtKB=O43237 O43237 DYNC1LI2 PTHR12688:SF1 DYNEIN LIGHT INTERMEDIATE CHAIN CYTOPLASMIC DYNEIN 1 LIGHT INTERMEDIATE CHAIN 2 protein binding#GO:0005515;binding#GO:0005488 organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;microtubule-based movement#GO:0007018;cytoskeleton organization#GO:0007010;cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226;microtubule-based process#GO:0007017 membraneless organelle#GO:0043228;centrosome#GO:0005813;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;chromosome, centromeric region#GO:0000775;condensed chromosome#GO:0000793;intracellular membraneless organelle#GO:0043232;supramolecular complex#GO:0099080;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;cytoplasmic dynein complex#GO:0005868;condensed chromosome, centromeric region#GO:0000779;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;organelle#GO:0043226;cellular anatomical structure#GO:0110165;kinetochore#GO:0000776;dynein complex#GO:0030286;chromosome#GO:0005694 microtubule or microtubule-binding cytoskeletal protein#PC00157 Huntington disease#P00029>Dynein complex#P00774 HUMAN|HGNC=20577|UniProtKB=Q6V0L0 Q6V0L0 CYP26C1 PTHR24286:SF100 CYTOCHROME P450 26 CYTOCHROME P450 26C1 oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;monooxygenase activity#GO:0004497 small molecule catabolic process#GO:0044282;central nervous system development#GO:0007417;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;regulation of hormone levels#GO:0010817;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;regulation of biological quality#GO:0065008;system development#GO:0048731;isoprenoid metabolic process#GO:0006720;anatomical structure development#GO:0048856;terpenoid metabolic process#GO:0006721;animal gross anatomical part developmental process#GO:0160108;oxoacid metabolic process#GO:0043436;nervous system development#GO:0007399;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;monocarboxylic acid catabolic process#GO:0072329;hormone metabolic process#GO:0042445;cellular process#GO:0009987;lipid catabolic process#GO:0016042;carboxylic acid catabolic process#GO:0046395;diterpenoid metabolic process#GO:0016101;retinoid metabolic process#GO:0001523;multicellular organism development#GO:0007275;lipid metabolic process#GO:0006629;developmental process#GO:0032502;metabolic process#GO:0008152 oxygenase#PC00177 HUMAN|HGNC=8221|UniProtKB=Q8NGS0 Q8NGS0 OR1N1 PTHR48001:SF43 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 1N1 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=9379|UniProtKB=O43741 O43741 PRKAB2 PTHR10343:SF92 5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-2 kinase binding#GO:0019900;binding#GO:0005488;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;protein binding#GO:0005515 cell communication#GO:0007154;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 transferase complex, transferring phosphorus-containing groups#GO:0061695;transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;protein kinase complex#GO:1902911;intracellular protein-containing complex#GO:0140535;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 kinase modulator#PC00140;protein-binding activity modulator#PC00095 Gonadotropin-releasing hormone receptor pathway#P06664>AMPK#P06830;p53 pathway by glucose deprivation#P04397>AMPK#P04639 HUMAN|HGNC=10727|UniProtKB=O15041 O15041 SEMA3E PTHR11036:SF22 SEMAPHORIN SEMAPHORIN-3E receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;binding#GO:0005488;signaling receptor binding#GO:0005102;protein binding#GO:0005515;molecular function activator activity#GO:0140677 regulation of cell migration#GO:0030334;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;cellular developmental process#GO:0048869;positive regulation of locomotion#GO:0040017;neuron projection guidance#GO:0097485;response to external stimulus#GO:0009605;neurogenesis#GO:0022008;axon guidance#GO:0007411;axon development#GO:0061564;positive regulation of cellular process#GO:0048522;positive regulation of cell migration#GO:0030335;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;plasma membrane bounded cell projection organization#GO:0120036;chemotaxis#GO:0006935;cell communication#GO:0007154;regulation of cell motility#GO:2000145;anatomical structure development#GO:0048856;system development#GO:0048731;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;locomotion#GO:0040011;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell surface receptor signaling pathway#GO:0007166;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cell projection morphogenesis#GO:0048858;neuron projection development#GO:0031175;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;response to chemical#GO:0042221;taxis#GO:0042330;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;neuron development#GO:0048666;axonogenesis#GO:0007409;positive regulation of cell motility#GO:2000147;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;response to stimulus#GO:0050896;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell morphogenesis#GO:0000902;signaling#GO:0023052;cell development#GO:0048468 cell periphery#GO:0071944;extracellular region#GO:0005576;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 membrane-bound signaling molecule#PC00152 HUMAN|HGNC=51831|UniProtKB=P0DN78 P0DN78 OPN1MW3 PTHR24240:SF17 OPSIN MEDIUM-WAVE-SENSITIVE OPSIN 1-RELATED transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089 regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to abiotic stimulus#GO:0009628;cellular response to radiation#GO:0071478;signaling#GO:0023052;response to stimulus#GO:0050896;response to light stimulus#GO:0009416;regulation of cellular process#GO:0050794;cellular response to environmental stimulus#GO:0104004;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;signal transduction#GO:0007165;cellular response to light stimulus#GO:0071482;response to radiation#GO:0009314;cellular process#GO:0009987;detection of stimulus#GO:0051606;biological regulation#GO:0065007;response to external stimulus#GO:0009605;cellular response to abiotic stimulus#GO:0071214 neuron projection#GO:0043005;cell periphery#GO:0071944;photoreceptor cell cilium#GO:0097733;9+0 non-motile cilium#GO:0097731;membrane#GO:0016020;plasma membrane#GO:0005886;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;photoreceptor outer segment#GO:0001750;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cilium#GO:0005929;membrane-bounded organelle#GO:0043227;non-motile cilium#GO:0097730 G-protein coupled receptor#PC00021 HUMAN|HGNC=24543|UniProtKB=Q52LR7 Q52LR7 EPC2 PTHR14898:SF4 ENHANCER OF POLYCOMB ENHANCER OF POLYCOMB HOMOLOG 2 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;cellular component organization#GO:0016043 catalytic complex#GO:1902494;intracellular organelle#GO:0043229;protein acetyltransferase complex#GO:0031248;acetyltransferase complex#GO:1902493;intracellular anatomical structure#GO:0005622;chromosome#GO:0005694;organelle#GO:0043226;cellular anatomical structure#GO:0110165;transferase complex#GO:1990234;histone acetyltransferase complex#GO:0000123;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;chromatin#GO:0000785;intracellular membraneless organelle#GO:0043232;NuA4 histone acetyltransferase complex#GO:0035267;protein-containing complex#GO:0032991;H4 histone acetyltransferase complex#GO:1902562 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=27639|UniProtKB=Q69YU3 Q69YU3 ANKRD34A PTHR24156:SF4 ANK_REP_REGION DOMAIN-CONTAINING PROTEIN ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 34A HUMAN|HGNC=688|UniProtKB=Q9H4E5 Q9H4E5 RHOJ PTHR24072:SF17 RHO FAMILY GTPASE RHO-RELATED GTP-BINDING PROTEIN RHOJ hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;kinase binding#GO:0019900;nucleoside phosphate binding#GO:1901265;guanyl nucleotide binding#GO:0019001;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;protein binding#GO:0005515;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;hydrolase activity, acting on acid anhydrides#GO:0016817;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;small molecule binding#GO:0036094;anion binding#GO:0043168;GTPase activity#GO:0003924;ion binding#GO:0043167;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleotide binding#GO:0000166 organelle organization#GO:0006996;signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;transport#GO:0006810;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;import into cell#GO:0098657;actin filament organization#GO:0007015;cellular component organization#GO:0016043;establishment of cell polarity#GO:0030010;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;endocytosis#GO:0006897;signaling#GO:0023052;establishment or maintenance of cell polarity#GO:0007163;actin filament-based process#GO:0030029;localization#GO:0051179;cell communication#GO:0007154;supramolecular fiber organization#GO:0097435 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 small GTPase#PC00208;G-protein#PC00020 Axon guidance mediated by Slit/Robo#P00008>Rho#P00355;Huntington disease#P00029>Rac#P00775;Cytoskeletal regulation by Rho GTPase#P00016>Rho#P00507;EGF receptor signaling pathway#P00018>Rac#P00564 HUMAN|HGNC=11724|UniProtKB=Q02763 Q02763 TEK PTHR24416:SF125 TYROSINE-PROTEIN KINASE RECEPTOR ANGIOPOIETIN-1 RECEPTOR transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;transmembrane receptor protein kinase activity#GO:0019199;signaling receptor activity#GO:0038023 cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;regulation of multicellular organismal process#GO:0051239;cell surface receptor signaling pathway#GO:0007166;regulation of MAPK cascade#GO:0043408;regulation of anatomical structure morphogenesis#GO:0022603;endothelial cell proliferation#GO:0001935;epithelial cell proliferation#GO:0050673;multicellular organism development#GO:0007275;anatomical structure formation involved in morphogenesis#GO:0048646;vasculature development#GO:0001944;positive regulation of angiogenesis#GO:0045766;blood vessel morphogenesis#GO:0048514;positive regulation of cell motility#GO:2000147;regulation of multicellular organismal development#GO:2000026;positive regulation of multicellular organismal process#GO:0051240;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051897;circulatory system development#GO:0072359;signaling#GO:0023052;regulation of intracellular signal transduction#GO:1902531;animal gross anatomical part developmental process#GO:0160108;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;angiogenesis#GO:0001525;positive regulation of cell migration#GO:0030335;positive regulation of cellular process#GO:0048522;multicellular organismal process#GO:0032501;positive regulation of response to stimulus#GO:0048584;regulation of locomotion#GO:0040012;tube development#GO:0035295;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of vasculature development#GO:1901342;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;regulation of cell migration#GO:0030334;positive regulation of developmental process#GO:0051094;developmental process#GO:0032502;positive regulation of MAPK cascade#GO:0043410;positive regulation of locomotion#GO:0040017;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;blood vessel development#GO:0001568;tube morphogenesis#GO:0035239;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of cell communication#GO:0010646;regulation of developmental process#GO:0050793;cell population proliferation#GO:0008283;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of cell motility#GO:2000145;cell communication#GO:0007154;regulation of angiogenesis#GO:0045765;regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051896;system development#GO:0048731 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;signaling receptor complex#GO:0043235;membrane#GO:0016020 transmembrane signal receptor#PC00197 Angiogenesis#P00005>Tie2#P00247 HUMAN|HGNC=16872|UniProtKB=Q8TB61 Q8TB61 SLC35B2 PTHR10778:SF13 SOLUTE CARRIER FAMILY 35 MEMBER B ADENOSINE 3'-PHOSPHO 5'-PHOSPHOSULFATE TRANSPORTER 1 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;carbohydrate derivative transmembrane transporter activity#GO:1901505;purine nucleotide transmembrane transporter activity#GO:0015216;organophosphate ester transmembrane transporter activity#GO:0015605;nucleobase-containing compound transmembrane transporter activity#GO:0015932 organophosphate ester transport#GO:0015748;nucleobase-containing compound transport#GO:0015931;cellular process#GO:0009987;carbohydrate derivative transport#GO:1901264;nitrogen compound transport#GO:0071705;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810 bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;endoplasmic reticulum#GO:0005783;endomembrane system#GO:0012505;cytoplasm#GO:0005737;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;intracellular membrane-bounded organelle#GO:0043231 secondary carrier transporter#PC00258 HUMAN|HGNC=6881|UniProtKB=P45983 P45983 MAPK8 PTHR24055:SF222 MITOGEN-ACTIVATED PROTEIN KINASE MITOGEN-ACTIVATED PROTEIN KINASE 8 catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;response to mechanical stimulus#GO:0009612;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;JNK cascade#GO:0007254;regulation of apoptotic process#GO:0042981;response to external stimulus#GO:0009605;positive regulation of apoptotic process#GO:0043065;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;response to abiotic stimulus#GO:0009628;regulation of programmed cell death#GO:0043067;signaling#GO:0023052;regulation of cellular process#GO:0050794;positive regulation of programmed cell death#GO:0043068;response to stimulus#GO:0050896;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;MAPK cascade#GO:0000165 nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 non-receptor serine/threonine protein kinase#PC00167 Interferon-gamma signaling pathway#P00035>Serine kinase#P00955;Alzheimer disease-amyloid secretase pathway#P00003>MAPK#P00099;Angiogenesis#P00005>JNK1#P00221;Ras Pathway#P04393>JNK#P04572;PDGF signaling pathway#P00047>ERK#P01143;B cell activation#P00010>Jnk#P00402;CCKR signaling map#P06959>MAPK8-10#P07090;Apoptosis signaling pathway#P00006>JNK#P00274;Gonadotropin-releasing hormone receptor pathway#P06664>JNK1/2#P06847;Oxidative stress response#P00046>JNK1/2#P01129;Parkinson disease#P00049>SAPK#P01219;Toll receptor signaling pathway#P00054>JNK#P01375;TGF-beta signaling pathway#P00052>JNK#P01284;T cell activation#P00053>Jnk#P01336;FGF signaling pathway#P00021>JNK1-3#P00628;Integrin signalling pathway#P00034>Jnk#P00951;FAS signaling pathway#P00020>JNK#P00615;EGF receptor signaling pathway#P00018>JNK1-3#P00545 HUMAN|HGNC=15679|UniProtKB=Q8WZ74 Q8WZ74 CTTNBP2 PTHR24166:SF27 ROLLING PEBBLES, ISOFORM B CORTACTIN-BINDING PROTEIN 2 regulation of biological process#GO:0050789;regulation of synapse organization#GO:0050807;biological regulation#GO:0065007;regulation of biological quality#GO:0065008;regulation of cellular component organization#GO:0051128;regulation of synapse structure or activity#GO:0050803;regulation of cellular process#GO:0050794 cell junction#GO:0030054;synapse#GO:0045202;glutamatergic synapse#GO:0098978;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=29786|UniProtKB=Q9NYZ2 Q9NYZ2 SLC25A37 PTHR45758:SF4 MITOFERRIN-1-RELATED MITOFERRIN-1 monoatomic cation transmembrane transporter activity#GO:0008324;metal ion transmembrane transporter activity#GO:0046873;iron ion transmembrane transporter activity#GO:0005381;monoatomic ion transmembrane transporter activity#GO:0015075;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;transition metal ion transmembrane transporter activity#GO:0046915 transition metal ion transport#GO:0000041;transport#GO:0006810;iron ion transmembrane transport#GO:0034755;iron ion transport#GO:0006826;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;localization#GO:0051179;cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001 intracellular organelle#GO:0043229;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=49544|UniProtKB=A0A1B0GVM6 A0A1B0GVM6 C11orf97 PTHR38326:SF1 CHROMOSOME 11 OPEN READING FRAME 97 CHROMOSOME 11 OPEN READING FRAME 97 HUMAN|HGNC=20398|UniProtKB=A6NH52 A6NH52 TVP23A PTHR13019:SF18 GOLGI APPARATUS MEMBRANE PROTEIN TVP23 GOLGI APPARATUS MEMBRANE PROTEIN TVP23 HOMOLOG A macromolecule localization#GO:0033036;protein localization to extracellular region#GO:0071692;cellular process#GO:0009987;establishment of protein localization#GO:0045184;vesicle-mediated transport#GO:0016192;export from cell#GO:0140352;transport#GO:0006810;establishment of localization#GO:0051234;secretion#GO:0046903;protein secretion#GO:0009306;localization#GO:0051179;protein transport#GO:0015031;establishment of protein localization to extracellular region#GO:0035592;secretion by cell#GO:0032940;intracellular protein localization#GO:0008104 Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;membrane#GO:0016020;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=8819|UniProtKB=O00764 O00764 PDXK PTHR10534:SF2 PYRIDOXAL KINASE PYRIDOXAL KINASE transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773 organophosphate biosynthetic process#GO:0090407;small molecule biosynthetic process#GO:0044283;pyridine-containing compound metabolic process#GO:0072524;metabolic process#GO:0008152;biosynthetic process#GO:0009058;small molecule metabolic process#GO:0044281;cellular process#GO:0009987;aldehyde metabolic process#GO:0006081;phosphorus metabolic process#GO:0006793;organophosphate metabolic process#GO:0019637 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 kinase#PC00137 Pyridoxal phosphate salvage pathway#P02770>Pyridoxamine kinase#P03122;Vitamin B6 metabolism#P02787>Pyridoxal kinase#P03244;Pyridoxal phosphate salvage pathway#P02770>Pyridoxal kinase#P03121 HUMAN|HGNC=2467|UniProtKB=O95196 O95196 CSPG5 PTHR15381:SF1 CHONDROITIN SULFATE PROTEOGLYCAN 5 -RELATED CHONDROITIN SULFATE PROTEOGLYCAN 5 developmental process#GO:0032502;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;axon development#GO:0061564;response to wounding#GO:0009611;plasma membrane bounded cell projection organization#GO:0120036;glial cell differentiation#GO:0010001;multicellular organismal process#GO:0032501;system development#GO:0048731;anatomical structure development#GO:0048856;cellular response to stimulus#GO:0051716;neuron differentiation#GO:0030182;gliogenesis#GO:0042063;cell projection morphogenesis#GO:0048858;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;neuron projection development#GO:0031175;response to stress#GO:0006950;nervous system development#GO:0007399;regeneration#GO:0031099;generation of neurons#GO:0048699;cellular response to stress#GO:0033554;animal gross anatomical part developmental process#GO:0160108;neuron development#GO:0048666;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;cell development#GO:0048468;cell projection organization#GO:0030030;cell differentiation#GO:0030154;response to stimulus#GO:0050896;cell morphogenesis#GO:0000902 cell junction#GO:0030054;postsynaptic membrane#GO:0045211;synaptic membrane#GO:0097060;plasma membrane region#GO:0098590;synapse#GO:0045202;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;postsynapse#GO:0098794;cell periphery#GO:0071944 HUMAN|HGNC=24244|UniProtKB=Q4ZJI4 Q4ZJI4 SLC9B1 PTHR31102:SF5 FAMILY NOT NAMED SLC9B1-LIKE PROTEIN SLC9B1P1-RELATED localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810;cellular process#GO:0009987 HUMAN|HGNC=13734|UniProtKB=Q6IB77 Q6IB77 GLYAT PTHR15298:SF9 L-COA N-ACYLTRANSFERASE-RELATED GLYCINE N-ACYLTRANSFERASE acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 acyltransferase#PC00042 HUMAN|HGNC=9896|UniProtKB=P98175 P98175 RBM10 PTHR13948:SF4 RNA-BINDING PROTEIN RNA-BINDING PROTEIN 10 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;gene expression#GO:0010467;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=10064|UniProtKB=O75382 O75382 TRIM3 PTHR24104:SF21 E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED TRIPARTITE MOTIF-CONTAINING PROTEIN 3 ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740 protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;protein modification process#GO:0036211;primary metabolic process#GO:0044238;catabolic process#GO:0009056;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;protein ubiquitination#GO:0016567;proteasomal protein catabolic process#GO:0010498;post-translational protein modification#GO:0043687 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 Alzheimer disease-presenilin pathway#P00004>HAC1#P00131 HUMAN|HGNC=28524|UniProtKB=Q8NCS7 Q8NCS7 SLC44A5 PTHR12385:SF42 CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44) CHOLINE TRANSPORTER-LIKE PROTEIN 5 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 cellular process#GO:0009987;transport#GO:0006810;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179 membrane#GO:0016020;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258;transporter#PC00227 HUMAN|HGNC=18062|UniProtKB=Q8TD30 Q8TD30 GPT2 PTHR11751:SF311 ALANINE AMINOTRANSFERASE ALANINE AMINOTRANSFERASE 2 transaminase#PC00216;transferase#PC00220 HUMAN|HGNC=2974|UniProtKB=P50570 P50570 DNM2 PTHR11566:SF23 DYNAMIN DYNAMIN-2 ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;cytoskeletal protein binding#GO:0008092;hydrolase activity, acting on acid anhydrides#GO:0016817;tubulin binding#GO:0015631;hydrolase activity#GO:0016787;protein binding#GO:0005515;microtubule binding#GO:0008017;GTPase activity#GO:0003924;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818 cellular component organization#GO:0016043;synaptic vesicle endocytosis#GO:0048488;endocytosis#GO:0006897;establishment of organelle localization#GO:0051656;organelle localization#GO:0051640;cellular localization#GO:0051641;localization#GO:0051179;cellular process#GO:0009987;vesicle localization#GO:0051648;establishment of localization in cell#GO:0051649;synaptic vesicle transport#GO:0048489;receptor internalization#GO:0031623;organelle organization#GO:0006996;membrane organization#GO:0061024;establishment of vesicle localization#GO:0051650;synaptic vesicle localization#GO:0097479;synaptic vesicle recycling#GO:0036465;vesicle-mediated transport#GO:0016192;synaptic vesicle cycle#GO:0099504;transport#GO:0006810;vesicle organization#GO:0016050;vesicle budding from membrane#GO:0006900;receptor-mediated endocytosis#GO:0006898;vesicle-mediated transport in synapse#GO:0099003;import into cell#GO:0098657;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840 synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membrane#GO:0016020;microtubule cytoskeleton#GO:0015630;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cell junction#GO:0030054 membrane traffic protein#PC00150 HUMAN|HGNC=12275|UniProtKB=P0CF51 P0CF51 TRGC1 PTHR19256:SF71 T-CELL RECEPTOR GAMMA CHAIN T CELL RECEPTOR GAMMA CONSTANT 1-RELATED immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=18797|UniProtKB=Q8NCW0 Q8NCW0 KREMEN2 PTHR24269:SF15 KREMEN PROTEIN KREMEN PROTEIN 2 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 Wnt signaling pathway#P00057>Kremen#P01463 HUMAN|HGNC=9764|UniProtKB=Q9UL26 Q9UL26 RAB22A PTHR24073:SF910 DRAB5-RELATED RAS-RELATED PROTEIN RAB-22A hydrolase activity, acting on acid anhydrides#GO:0016817;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787 localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;intracellular protein localization#GO:0008104;endosomal transport#GO:0016197;protein transport#GO:0015031;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810;vesicle-mediated transport#GO:0016192;macromolecule localization#GO:0033036;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987 intracellular organelle#GO:0043229;endosome#GO:0005768;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;late endosome#GO:0005770;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 G-protein#PC00020;small GTPase#PC00208 HUMAN|HGNC=30577|UniProtKB=Q96AX9 Q96AX9 MIB2 PTHR24202:SF4 E3 UBIQUITIN-PROTEIN LIGASE MIB2 E3 UBIQUITIN-PROTEIN LIGASE MIB2-RELATED ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824 metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647;macromolecule metabolic process#GO:0043170;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;cellular process#GO:0009987;protein modification process#GO:0036211;primary metabolic process#GO:0044238;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=14279|UniProtKB=Q6P1L8 Q6P1L8 MRPL14 PTHR21037:SF3 39S RIBOSOMAL PROTEIN L14, MITOCHONDRIAL LARGE RIBOSOMAL SUBUNIT PROTEIN UL14M mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 translational protein#PC00263;ribosomal protein#PC00202 HUMAN|HGNC=7133|UniProtKB=O14686 O14686 KMT2D PTHR45888:SF2 HL01030P-RELATED HISTONE-LYSINE N-METHYLTRANSFERASE 2D protein methyltransferase activity#GO:0008276;transcription coregulator activity#GO:0003712;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;N-methyltransferase activity#GO:0008170;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;histone H3 methyltransferase activity#GO:0140938;histone H3K4 methyltransferase activity#GO:0042800;transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;transcription coactivator activity#GO:0003713;histone methyltransferase activity#GO:0042054;protein-lysine N-methyltransferase activity#GO:0016279;transcription regulator activity#GO:0140110;methyltransferase activity#GO:0008168;histone modifying activity#GO:0140993;lysine N-methyltransferase activity#GO:0016278 regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 methyltransferase complex#GO:0034708;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234;histone methyltransferase complex#GO:0035097 HUMAN|HGNC=11344|UniProtKB=Q9Y5Y6 Q9Y5Y6 ST14 PTHR24253:SF50 TRANSMEMBRANE PROTEASE SERINE SUPPRESSOR OF TUMORIGENICITY 14 PROTEIN catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;serine hydrolase activity#GO:0017171;serine-type peptidase activity#GO:0008236;catalytic activity#GO:0003824 protein metabolic process#GO:0019538;anatomical structure development#GO:0048856;proteolysis#GO:0006508;keratinocyte differentiation#GO:0030216;animal gross anatomical part developmental process#GO:0160108;cell differentiation#GO:0030154;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;animal organ development#GO:0048513;cellular developmental process#GO:0048869;developmental process#GO:0032502;metabolic process#GO:0008152;epidermis development#GO:0008544;skin development#GO:0043588;biosynthetic process#GO:0009058;epithelium development#GO:0060429;epithelial cell differentiation#GO:0030855;protein maturation#GO:0051604;epidermal cell differentiation#GO:0009913;tissue development#GO:0009888;gene expression#GO:0010467;protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 protein modifying enzyme#PC00260;serine protease#PC00203;protease#PC00190 HUMAN|HGNC=18685|UniProtKB=Q7Z5P4 Q7Z5P4 HSD17B13 PTHR24322:SF499 PKSB 17-BETA-HYDROXYSTEROID DEHYDROGENASE 13 oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824 dehydrogenase#PC00092 HUMAN|HGNC=28328|UniProtKB=O60293 O60293 ZFC3H1 PTHR21563:SF3 ZINC FINGER C3H1 DOMAIN-CONTAINING PROTEIN ZINC FINGER C3H1 DOMAIN-CONTAINING PROTEIN nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|Ensembl=ENSG00000293606.1|UniProtKB=A0ABB0MV19 A0ABB0MV19 PTHR11819:SF150 SOLUTE CARRIER FAMILY 5 SMALL RIBOSOMAL SUBUNIT PROTEIN BS6M-RELATED metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;solute:monoatomic cation symporter activity#GO:0015294;monoatomic ion transmembrane transporter activity#GO:0015075;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;solute:sodium symporter activity#GO:0015370;symporter activity#GO:0015293 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227;secondary carrier transporter#PC00258 HUMAN|HGNC=8042|UniProtKB=Q9Y5Y2 Q9Y5Y2 NUBP2 PTHR23264:SF19 NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP2 binding#GO:0005488;small molecule binding#GO:0036094;iron-sulfur cluster binding#GO:0051536 iron-sulfur cluster assembly#GO:0016226;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;cellular process#GO:0009987;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 HUMAN|HGNC=9279|UniProtKB=Q9P0J1 Q9P0J1 PDP1 PTHR13832:SF627 PROTEIN PHOSPHATASE 2C [PYRUVATE DEHYDROGENASE [ACETYL-TRANSFERRING]]-PHOSPHATASE 1, MITOCHONDRIAL hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721;protein serine/threonine phosphatase activity#GO:0004722;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096 cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 protein phosphatase#PC00195 HUMAN|HGNC=19365|UniProtKB=Q9H999 Q9H999 PANK3 PTHR12280:SF21 PANTOTHENATE KINASE PANTOTHENATE KINASE 3 phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;purine-containing compound metabolic process#GO:0072521;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound biosynthetic process#GO:0072522;organophosphate biosynthetic process#GO:0090407;organophosphate metabolic process#GO:0019637;sulfur compound metabolic process#GO:0006790;cellular process#GO:0009987;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing small molecule metabolic process#GO:0055086 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cytosol#GO:0005829;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 metabolite interconversion enzyme#PC00262;kinase#PC00137 Coenzyme A biosynthesis#P02736>Pantothenate kinase#P02885 HUMAN|HGNC=25856|UniProtKB=Q9H825 Q9H825 METTL8 PTHR22809:SF3 METHYLTRANSFERASE-RELATED TRNA N(3)-CYTIDINE METHYLTRANSFERASE METTL8, MITOCHONDRIAL tRNA methyltransferase activity#GO:0008175;RNA methyltransferase activity#GO:0008173;catalytic activity, acting on RNA#GO:0140098;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on a tRNA#GO:0140101;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168 methyltransferase#PC00155 HUMAN|HGNC=8972|UniProtKB=O00750 O00750 PIK3C2B PTHR10048:SF30 PHOSPHATIDYLINOSITOL KINASE PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA kinase activity#GO:0016301;phosphatidylinositol kinase activity#GO:0052742;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;lipid kinase activity#GO:0001727;phosphotransferase activity, alcohol group as acceptor#GO:0016773 cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phospholipid metabolic process#GO:0006644;signaling#GO:0023052;regulation of cellular process#GO:0050794;phospholipid biosynthetic process#GO:0008654;cell motility#GO:0048870;response to stimulus#GO:0050896;glycerolipid metabolic process#GO:0046486;phosphatidylinositol phosphate biosynthetic process#GO:0046854;intracellular signal transduction#GO:0035556;organophosphate biosynthetic process#GO:0090407;cell communication#GO:0007154;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0043491;signal transduction#GO:0007165;organophosphate metabolic process#GO:0019637;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;biosynthetic process#GO:0009058;cell migration#GO:0016477;lipid biosynthetic process#GO:0008610;glycerophospholipid metabolic process#GO:0006650;lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 kinase#PC00137 Angiogenesis#P00005>PI3K#P00236;p53 pathway#P00059>PI3K#P04609;Endothelin signaling pathway#P00019>PI3K#P00577;EGF receptor signaling pathway#P00018>PI3K#P00557;Hypoxia response via HIF activation#P00030>PI3K#P00823;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>PI3K#P00900;p53 pathway feedback loops 2#P04398>PI3K#P04661;FGF signaling pathway#P00021>PI3K#P00640;Integrin signalling pathway#P00034>PI3K#P00936;VEGF signaling pathway#P00056>PI3K#P01413;Axon guidance mediated by netrin#P00009>PI3K#P00363 HUMAN|HGNC=11040|UniProtKB=Q92911 Q92911 SLC5A5 PTHR42985:SF11 SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER SODIUM_IODIDE COTRANSPORTER active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;solute:monoatomic cation symporter activity#GO:0015294;monoatomic ion transmembrane transporter activity#GO:0015075;secondary active transmembrane transporter activity#GO:0015291;monoatomic anion transmembrane transporter activity#GO:0008509;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic cation transmembrane transporter activity#GO:0008324;solute:sodium symporter activity#GO:0015370;symporter activity#GO:0015293 monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;monoatomic anion transmembrane transport#GO:0098656;cellular process#GO:0009987;sodium ion transport#GO:0006814;monoatomic anion transport#GO:0006820;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;transport#GO:0006810 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 secondary carrier transporter#PC00258;transporter#PC00227 HUMAN|HGNC=24063|UniProtKB=Q96C23 Q96C23 GALM PTHR10091:SF0 ALDOSE-1-EPIMERASE GALACTOSE MUTAROTASE isomerase activity#GO:0016853;racemase and epimerase activity#GO:0016854;racemase and epimerase activity, acting on carbohydrates and derivatives#GO:0016857;catalytic activity#GO:0003824 catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;small molecule catabolic process#GO:0044282;carbohydrate metabolic process#GO:0005975;phosphorus metabolic process#GO:0006793;hexose metabolic process#GO:0019318;primary metabolic process#GO:0044238;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;glucose metabolic process#GO:0006006;carbohydrate catabolic process#GO:0016052;monosaccharide metabolic process#GO:0005996;metabolic process#GO:0008152 epimerase/racemase#PC00096 HUMAN|HGNC=14695|UniProtKB=Q8NGV5 Q8NGV5 OR13D1 PTHR26453:SF0 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 13D1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 detection of chemical stimulus#GO:0009593;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;response to stimulus#GO:0050896;response to chemical#GO:0042221;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;sensory perception#GO:0007600;nervous system process#GO:0050877;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;system process#GO:0003008 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=9439|UniProtKB=Q13217 Q13217 DNAJC3 PTHR44140:SF3 LD25575P DNAJ HOMOLOG SUBFAMILY C MEMBER 3 protein binding#GO:0005515;protein-folding chaperone binding#GO:0051087;binding#GO:0005488 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;protein folding#GO:0006457;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=1394|UniProtKB=O43497 O43497 CACNA1G PTHR10037:SF137 VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1G transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;voltage-gated sodium channel activity#GO:0005248;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;sodium channel activity#GO:0005272;monoatomic cation channel activity#GO:0005261;sodium ion transmembrane transporter activity#GO:0015081;voltage-gated calcium channel activity#GO:0005245;channel activity#GO:0015267 membrane depolarization#GO:0051899;metal ion transport#GO:0030001;regulation of cellular process#GO:0050794;calcium ion import#GO:0070509;regulation of exocytosis#GO:0017157;regulation of secretion#GO:0051046;monoatomic cation transport#GO:0006812;localization#GO:0051179;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;positive regulation of cellular process#GO:0048522;establishment of localization#GO:0051234;transport#GO:0006810;regulation of vesicle-mediated transport#GO:0060627;action potential#GO:0001508;regulation of biological process#GO:0050789;calcium ion transmembrane transport#GO:0070588;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;regulation of secretion by cell#GO:1903530;transmembrane transport#GO:0055085;positive regulation of secretion#GO:0051047;positive regulation of cytosolic calcium ion concentration#GO:0007204;monoatomic cation transmembrane transport#GO:0098655;positive regulation of transport#GO:0051050;positive regulation of secretion by cell#GO:1903532;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of localization#GO:0032879;regulation of transport#GO:0051049;calcium ion transport#GO:0006816;calcium ion transmembrane import into cytosol#GO:0097553;regulation of membrane potential#GO:0042391 plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;neuron projection#GO:0043005;membrane#GO:0016020;membrane protein complex#GO:0098796;sodium channel complex#GO:0034706;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cation channel complex#GO:0034703 voltage-gated ion channel#PC00241 Endogenous cannabinoid signaling#P05730>Ca2+ channel#P05750;GABA-B receptor II signaling#P05731>Ca channel#P05753;Nicotine pharmacodynamics pathway#P06587>CACNA#P06600 HUMAN|HGNC=11647|UniProtKB=Q13488 Q13488 TCIRG1 PTHR11629:SF21 VACUOLAR PROTON ATPASES V-TYPE PROTON ATPASE 116 KDA SUBUNIT A 3 monoatomic cation transmembrane transporter activity#GO:0008324;protein binding#GO:0005515;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;enzyme binding#GO:0019899;binding#GO:0005488;active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;proton transmembrane transporter activity#GO:0015078 localization#GO:0051179;monoatomic cation transport#GO:0006812;vacuole organization#GO:0007033;regulation of pH#GO:0006885;organelle assembly#GO:0070925;regulation of intracellular pH#GO:0051453;catabolic process#GO:0009056;protein-containing complex disassembly#GO:0032984;homeostatic process#GO:0042592;vacuolar acidification#GO:0007035;establishment of localization#GO:0051234;proton transmembrane transport#GO:1902600;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;autophagosome maturation#GO:0097352;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;transport#GO:0006810;monoatomic ion transmembrane transport#GO:0034220;macroautophagy#GO:0016236;biological regulation#GO:0065007;cellular component disassembly#GO:0022411;transmembrane transport#GO:0055085;process utilizing autophagic mechanism#GO:0061919;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;cellular component organization#GO:0016043;intracellular monoatomic ion homeostasis#GO:0006873;cellular component organization or biogenesis#GO:0071840;autophagosome assembly#GO:0000045;protein-containing complex organization#GO:0043933;metabolic process#GO:0008152;chemical homeostasis#GO:0048878;cellular component assembly#GO:0022607;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion homeostasis#GO:0050801;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;autophagosome organization#GO:1905037;cellular process#GO:0009987;autophagy#GO:0006914 apical plasma membrane#GO:0016324;membrane protein complex#GO:0098796;cation-transporting ATPase complex#GO:0090533;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;ATPase complex#GO:1904949;vacuolar proton-transporting V-type ATPase complex#GO:0016471;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transmembrane transporter complex#GO:1902495;intracellular anatomical structure#GO:0005622;ATPase dependent transmembrane transport complex#GO:0098533;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;cell periphery#GO:0071944;protein-containing complex#GO:0032991;plasma membrane region#GO:0098590;cytoplasm#GO:0005737;plasma membrane#GO:0005886;vacuole#GO:0005773;proton-transporting two-sector ATPase complex#GO:0016469;apical part of cell#GO:0045177;vacuolar membrane#GO:0005774;transporter complex#GO:1990351;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;proton-transporting V-type ATPase complex#GO:0033176 ATP synthase#PC00002 HUMAN|HGNC=7631|UniProtKB=P17050 P17050 NAGA PTHR11452:SF25 ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE ALPHA-N-ACETYLGALACTOSAMINIDASE hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 metabolic process#GO:0008152;oligosaccharide metabolic process#GO:0009311;primary metabolic process#GO:0044238;glycosyl compound catabolic process#GO:1901658;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;catabolic process#GO:0009056;carbohydrate derivative catabolic process#GO:1901136;carbohydrate metabolic process#GO:0005975 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 hydrolase#PC00121;galactosidase#PC00104 HUMAN|HGNC=26379|UniProtKB=Q8N7B9 Q8N7B9 EFCAB3 PTHR47500:SF2 EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 3 calmodulin-related#PC00061;calcium-binding protein#PC00060 HUMAN|HGNC=6281|UniProtKB=Q9Y257 Q9Y257 KCNK6 PTHR11003:SF28 POTASSIUM CHANNEL, SUBFAMILY K POTASSIUM CHANNEL SUBFAMILY K MEMBER 6 transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261;outward rectifier potassium channel activity#GO:0015271;potassium channel activity#GO:0005267;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832 transport#GO:0006810;monoatomic cation transport#GO:0006812;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;potassium ion transport#GO:0006813;metal ion transport#GO:0030001;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 ion channel#PC00133;transporter#PC00227 HUMAN|HGNC=13902|UniProtKB=O75635 O75635 SERPINB7 PTHR11461:SF56 SERINE PROTEASE INHIBITOR, SERPIN SERPIN B7 enzyme regulator activity#GO:0030234;serine-type endopeptidase inhibitor activity#GO:0004867;molecular function inhibitor activity#GO:0140678;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;peptidase regulator activity#GO:0061134;endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772;enzyme inhibitor activity#GO:0004857 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease inhibitor#PC00191 HUMAN|HGNC=24306|UniProtKB=Q96RS6 Q96RS6 NUDCD1 PTHR21664:SF1 CHRONIC MYELOGENOUS LEUKEMIA TUMOR ANTIGEN 66 NUDC DOMAIN-CONTAINING PROTEIN 1 HUMAN|HGNC=15424|UniProtKB=A6NFC9 A6NFC9 OR2W5P PTHR26453:SF79 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2W5-RELATED transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;nervous system process#GO:0050877;sensory perception#GO:0007600;system process#GO:0003008;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;detection of chemical stimulus#GO:0009593;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;response to chemical#GO:0042221;response to stimulus#GO:0050896 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=27220|UniProtKB=A2RRL7 A2RRL7 TMEM213 PTHR36293:SF1 TRANSMEMBRANE PROTEIN 213 TRANSMEMBRANE PROTEIN 213 organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783 HUMAN|HGNC=1488|UniProtKB=P52907 P52907 CAPZA1 PTHR10653:SF5 F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA-1 protein-containing complex binding#GO:0044877;protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;actin filament binding#GO:0051015;binding#GO:0005488 regulation of cellular component organization#GO:0051128;regulation of cellular component biogenesis#GO:0044087;negative regulation of actin filament polymerization#GO:0030837;cellular component organization#GO:0016043;regulation of protein-containing complex assembly#GO:0043254;negative regulation of biological process#GO:0048519;regulation of organelle organization#GO:0033043;regulation of cellular component size#GO:0032535;regulation of biological process#GO:0050789;regulation of biological quality#GO:0065008;negative regulation of actin filament depolymerization#GO:0030835;regulation of actin filament length#GO:0030832;regulation of actin cytoskeleton organization#GO:0032956;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;regulation of protein-containing complex disassembly#GO:0043244;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;regulation of anatomical structure size#GO:0090066;regulation of cellular process#GO:0050794;actin cytoskeleton organization#GO:0030036;regulation of cytoskeleton organization#GO:0051493;regulation of protein polymerization#GO:0032271;negative regulation of supramolecular fiber organization#GO:1902904;regulation of actin filament depolymerization#GO:0030834;negative regulation of organelle organization#GO:0010639;negative regulation of cellular component organization#GO:0051129;regulation of supramolecular fiber organization#GO:1902903;negative regulation of protein-containing complex disassembly#GO:0043242;negative regulation of cytoskeleton organization#GO:0051494;negative regulation of protein-containing complex assembly#GO:0031333;actin filament-based process#GO:0030029;actin filament capping#GO:0051693;negative regulation of protein polymerization#GO:0032272;regulation of actin filament polymerization#GO:0030833;negative regulation of protein depolymerization#GO:1901880;biological regulation#GO:0065007;regulation of actin polymerization or depolymerization#GO:0008064;regulation of actin filament organization#GO:0110053;regulation of protein depolymerization#GO:1901879;regulation of actin filament-based process#GO:0032970;negative regulation of cellular process#GO:0048523 organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;actin cytoskeleton#GO:0015629;cortical cytoskeleton#GO:0030863;cell cortex#GO:0005938;cell periphery#GO:0071944;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 non-motor actin binding protein#PC00165 HUMAN|HGNC=10617|UniProtKB=Q99731 Q99731 CCL19 PTHR12015:SF80 SMALL INDUCIBLE CYTOKINE A C-C MOTIF CHEMOKINE 19 chemokine activity#GO:0008009;G protein-coupled receptor binding#GO:0001664;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;cytokine activity#GO:0005125;signaling receptor binding#GO:0005102;cytokine receptor binding#GO:0005126;binding#GO:0005488;molecular function activator activity#GO:0140677;protein binding#GO:0005515;chemokine receptor binding#GO:0042379 cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;defense response to symbiont#GO:0140546;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;response to chemokine#GO:1990868;defense response to other organism#GO:0098542;granulocyte migration#GO:0097530;response to cytokine#GO:0034097;taxis#GO:0042330;response to chemical#GO:0042221;cell surface receptor signaling pathway#GO:0007166;humoral immune response#GO:0006959;antimicrobial humoral response#GO:0019730;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;positive regulation of cell motility#GO:2000147;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;granulocyte chemotaxis#GO:0071621;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;immune system process#GO:0002376;response to peptide#GO:1901652;positive regulation of cell migration#GO:0030335;immune response#GO:0006955;positive regulation of cellular process#GO:0048522;response to other organism#GO:0051707;regulation of locomotion#GO:0040012;biological regulation#GO:0065007;cell migration#GO:0016477;regulation of cell migration#GO:0030334;leukocyte migration#GO:0050900;defense response#GO:0006952;leukocyte chemotaxis#GO:0030595;response to external stimulus#GO:0009605;myeloid leukocyte migration#GO:0097529;positive regulation of locomotion#GO:0040017;cellular response to stimulus#GO:0051716;cellular response to chemokine#GO:1990869;locomotion#GO:0040011;response to external biotic stimulus#GO:0043207;cell motility#GO:0048870;regulation of cellular process#GO:0050794;inflammatory response#GO:0006954;chemotaxis#GO:0006935;cytokine-mediated signaling pathway#GO:0019221;cell chemotaxis#GO:0060326;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;regulation of cell motility#GO:2000145;cell communication#GO:0007154;chemokine-mediated signaling pathway#GO:0070098 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 cytokine#PC00083 HUMAN|HGNC=3225|UniProtKB=P52803 P52803 EFNA5 PTHR11304:SF33 EPHRIN EPHRIN-A5 protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488 animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;axonogenesis#GO:0007409;neuron development#GO:0048666;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;regulation of cellular component organization#GO:0051128;cell projection organization#GO:0030030;cell differentiation#GO:0030154;response to stimulus#GO:0050896;cell morphogenesis#GO:0000902;signaling#GO:0023052;cell development#GO:0048468;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell surface receptor signaling pathway#GO:0007166;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cell projection morphogenesis#GO:0048858;neuron projection development#GO:0031175;signal transduction#GO:0007165;cellular process#GO:0009987;cell morphogenesis involved in neuron differentiation#GO:0048667;regulation of actin cytoskeleton organization#GO:0032956;nervous system development#GO:0007399;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;system development#GO:0048731;cellular response to stimulus#GO:0051716;ephrin receptor signaling pathway#GO:0048013;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794;regulation of cell-cell adhesion#GO:0022407;regulation of actin filament-based process#GO:0032970;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;cellular developmental process#GO:0048869;neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;axon development#GO:0061564;axon guidance#GO:0007411;regulation of cell adhesion#GO:0030155;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036 plasma membrane#GO:0005886;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020 membrane-bound signaling molecule#PC00152;intercellular signal molecule#PC00207 HUMAN|HGNC=8762|UniProtKB=Q16342 Q16342 PDCD2 PTHR12298:SF8 PCDC2 PROGRAMMED CELL DEATH PROTEIN 2 -RELATED US5 ASSEMBLY CHAPERONE PDCD2 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=6217|UniProtKB=Q9BVA0 Q9BVA0 KATNB1 PTHR19845:SF0 KATANIN P80 SUBUNIT KATANIN P80 WD40 REPEAT-CONTAINING SUBUNIT B1 cellular component organization#GO:0016043;organelle organization#GO:0006996;microtubule polymerization or depolymerization#GO:0031109;cellular process#GO:0009987;microtubule depolymerization#GO:0007019;protein depolymerization#GO:0051261;protein-containing complex disassembly#GO:0032984;cytoskeleton organization#GO:0007010;cellular component disassembly#GO:0022411;microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;microtubule-based process#GO:0007017;supramolecular fiber organization#GO:0097435 intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;microtubule associated complex#GO:0005875;microtubule cytoskeleton#GO:0015630;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856 HUMAN|HGNC=17144|UniProtKB=Q8TCD5 Q8TCD5 NT5C PTHR16504:SF5 5'(3')-DEOXYRIBONUCLEOTIDASE 5'(3')-DEOXYRIBONUCLEOTIDASE, CYTOSOLIC TYPE hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;phosphatase activity#GO:0016791;nucleotidase activity#GO:0008252;hydrolase activity, acting on ester bonds#GO:0016788;5'-nucleotidase activity#GO:0008253;catalytic activity#GO:0003824 nucleobase-containing compound catabolic process#GO:0034655;organophosphate metabolic process#GO:0019637;pyrimidine-containing compound metabolic process#GO:0072527;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;nucleobase-containing compound metabolic process#GO:0006139;nucleotide catabolic process#GO:0009166;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;nucleoside phosphate catabolic process#GO:1901292;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;carbohydrate derivative catabolic process#GO:1901136;organophosphate catabolic process#GO:0046434;nucleotide metabolic process#GO:0009117 HUMAN|HGNC=7691|UniProtKB=O95182 O95182 NDUFA7 PTHR12485:SF1 NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 7 electron transport chain#GO:0022900;respiratory electron transport chain#GO:0022904;cellular process#GO:0009987;mitochondrial ATP synthesis coupled electron transport#GO:0042775;aerobic electron transport chain#GO:0019646;metabolic process#GO:0008152;mitochondrial electron transport, NADH to ubiquinone#GO:0006120;generation of precursor metabolites and energy#GO:0006091;energy derivation by oxidation of organic compounds#GO:0015980;cellular respiration#GO:0045333;ATP synthesis coupled electron transport#GO:0042773;oxidative phosphorylation#GO:0006119;aerobic respiration#GO:0009060 transmembrane transporter complex#GO:1902495;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;organelle envelope#GO:0031967;mitochondrion#GO:0005739;transporter complex#GO:1990351;organelle membrane#GO:0031090;respiratory chain complex I#GO:0045271;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;mitochondrial inner membrane#GO:0005743;oxidoreductase complex#GO:1990204;membrane#GO:0016020;respiratory chain complex#GO:0098803;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HUMAN|HGNC=14526|UniProtKB=Q9Y3Q0 Q9Y3Q0 NAALAD2 PTHR10404:SF38 N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE 2 catalytic activity#GO:0003824;exopeptidase activity#GO:0008238;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;carboxypeptidase activity#GO:0004180 metalloprotease#PC00153 HUMAN|HGNC=11111|UniProtKB=Q14683 Q14683 SMC1A PTHR18937:SF170 STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 1A binding#GO:0005488;nucleic acid binding#GO:0003676;DNA binding#GO:0003677 cellular process#GO:0009987;cell cycle process#GO:0022402;cell cycle#GO:0007049;organelle organization#GO:0006996;cellular component organization#GO:0016043;chromosome organization#GO:0051276;cellular component organization or biogenesis#GO:0071840;sister chromatid cohesion#GO:0007062 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cohesin complex#GO:0008278;organelle#GO:0043226;nucleus#GO:0005634;chromosome#GO:0005694 HUMAN|HGNC=29868|UniProtKB=Q9UI15 Q9UI15 TAGLN3 PTHR47385:SF10 CALPONIN TRANSGELIN-3 protein-containing complex binding#GO:0044877;protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;actin filament binding#GO:0051015;binding#GO:0005488 actin filament organization#GO:0007015;supramolecular fiber organization#GO:0097435;cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996 actin cytoskeleton#GO:0015629;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=9038|UniProtKB=P39877 P39877 PLA2G5 PTHR11716:SF10 PHOSPHOLIPASE A2 FAMILY MEMBER PHOSPHOLIPASE A2 GROUP V phospholipid binding#GO:0005543;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;cation binding#GO:0043169;ion binding#GO:0043167;lipase activity#GO:0016298;small molecule binding#GO:0036094;carboxylic ester hydrolase activity#GO:0052689;A2-type glycerophospholipase activity#GO:0004623;glycerophospholipase activity#GO:0004620;phospholipase activity#GO:0120569;metal ion binding#GO:0046872;lipid binding#GO:0008289;binding#GO:0005488;calcium ion binding#GO:0005509 negative regulation of T cell activation#GO:0050868;regulation of cell population proliferation#GO:0042127;primary metabolic process#GO:0044238;negative regulation of multicellular organismal process#GO:0051241;negative regulation of leukocyte cell-cell adhesion#GO:1903038;phospholipid metabolic process#GO:0006644;regulation of cell-cell adhesion#GO:0022407;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of T cell proliferation#GO:0042129;phosphatidylglycerol metabolic process#GO:0046471;lipid metabolic process#GO:0006629;negative regulation of cellular process#GO:0048523;regulation of leukocyte cell-cell adhesion#GO:1903037;negative regulation of cell activation#GO:0050866;negative regulation of cell population proliferation#GO:0008285;organophosphate metabolic process#GO:0019637;biological regulation#GO:0065007;negative regulation of immune system process#GO:0002683;regulation of lymphocyte proliferation#GO:0050670;regulation of cell adhesion#GO:0030155;negative regulation of cell adhesion#GO:0007162;regulation of cell activation#GO:0050865;regulation of biological process#GO:0050789;phosphorus metabolic process#GO:0006793;negative regulation of biological process#GO:0048519;regulation of leukocyte activation#GO:0002694;regulation of lymphocyte activation#GO:0051249;glycerolipid metabolic process#GO:0046486;metabolic process#GO:0008152;negative regulation of T cell proliferation#GO:0042130;regulation of leukocyte proliferation#GO:0070663;cellular process#GO:0009987;regulation of mononuclear cell proliferation#GO:0032944;negative regulation of lymphocyte activation#GO:0051250;negative regulation of leukocyte activation#GO:0002695;regulation of multicellular organismal process#GO:0051239;regulation of T cell activation#GO:0050863;glycerophospholipid metabolic process#GO:0006650;negative regulation of cell-cell adhesion#GO:0022408;phosphatidylcholine metabolic process#GO:0046470 phospholipase#PC00186 HUMAN|HGNC=26077|UniProtKB=Q8TCQ1 Q8TCQ1 MARCHF1 PTHR45981:SF1 LD02310P E3 UBIQUITIN-PROTEIN LIGASE MARCHF1 catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein binding#GO:0005515;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;MHC protein binding#GO:0042287;signaling receptor binding#GO:0005102;binding#GO:0005488;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630 protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;immune response#GO:0006955;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;response to stimulus#GO:0050896;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;antigen processing and presentation#GO:0019882;immune system process#GO:0002376;protein modification by small protein conjugation or removal#GO:0070647 intracellular organelle#GO:0043229;endosome membrane#GO:0010008;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;early endosome#GO:0005769;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular vesicle#GO:0097708;vesicle#GO:0031982;lysosome#GO:0005764;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;late endosome membrane#GO:0031902;early endosome membrane#GO:0031901;lytic vacuole#GO:0000323;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;membrane#GO:0016020;late endosome#GO:0005770;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;vacuole#GO:0005773;cytoplasm#GO:0005737 HUMAN|HGNC=25835|UniProtKB=Q6ZMP0 Q6ZMP0 THSD4 PTHR13723:SF16 ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE THROMBOSPONDIN TYPE-1 DOMAIN-CONTAINING PROTEIN 4 metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096 extracellular structure organization#GO:0043062;metabolic process#GO:0008152;proteolysis#GO:0006508;extracellular matrix organization#GO:0030198;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;external encapsulating structure organization#GO:0045229;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012 metalloprotease#PC00153 HUMAN|HGNC=28722|UniProtKB=Q5HYK3 Q5HYK3 COQ5 PTHR43591:SF116 METHYLTRANSFERASE 2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL catalytic activity#GO:0003824;transferase activity#GO:0016740;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741 small molecule metabolic process#GO:0044281;biosynthetic process#GO:0009058;ketone metabolic process#GO:0042180;ketone biosynthetic process#GO:0042181;cellular process#GO:0009987;ubiquinone biosynthetic process#GO:0006744;metabolic process#GO:0008152;small molecule biosynthetic process#GO:0044283 methyltransferase#PC00155;transferase#PC00220 HUMAN|HGNC=29185|UniProtKB=Q4KWH8 Q4KWH8 PLCH1 PTHR10336:SF51 PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN 1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ETA-1 phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity, acting on ester bonds#GO:0016788;phospholipase activity#GO:0120569;glycerophospholipase activity#GO:0004620;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;lipase activity#GO:0016298 regulation of cell communication#GO:0010646;signaling#GO:0023052;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;modulation of chemical synaptic transmission#GO:0050804;regulation of cellular process#GO:0050794;regulation of trans-synaptic signaling#GO:0099177;cellular process#GO:0009987;regulation of biological process#GO:0050789;cell communication#GO:0007154;regulation of signaling#GO:0023051 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 hydrolase#PC00121;lipase#PC00143;metabolite interconversion enzyme#PC00262;phospholipase#PC00186 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PLCbetagamma#P00874;Thyrotropin-releasing hormone receptor signaling pathway#P04394>PLC#P04581;5HT2 type receptor mediated signaling pathway#P04374>PLC#P04412;Histamine H1 receptor mediated signaling pathway#P04385>PLC#P04484;Oxytocin receptor mediated signaling pathway#P04391>PLC beta#P04530 HUMAN|HGNC=37|UniProtKB=Q8IZY2 Q8IZY2 ABCA7 PTHR19229:SF49 ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA PHOSPHOLIPID-TRANSPORTING ATPASE ABCA7 intramembrane lipid carrier activity#GO:0140303;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626;lipid carrier activity#GO:0005319;phosphatidylcholine intramembrane carrier activity#GO:0008525;molecular carrier activity#GO:0140104;active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399;signaling receptor activity#GO:0038023;cargo receptor activity#GO:0038024;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;ATPase-coupled intramembrane lipid carrier activity#GO:0140326 localization#GO:0051179;sterol transport#GO:0015918;establishment of localization#GO:0051234;organic hydroxy compound transport#GO:0015850;lipid localization#GO:0010876;transport#GO:0006810;organophosphate ester transport#GO:0015748;lipid transport#GO:0006869;phospholipid transport#GO:0015914;macromolecule localization#GO:0033036;cholesterol transport#GO:0030301;cholesterol efflux#GO:0033344 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229 ATP-binding cassette (ABC) transporter#PC00003 HUMAN|HGNC=14463|UniProtKB=Q8N1S5 Q8N1S5 SLC39A11 PTHR11040:SF211 ZINC/IRON TRANSPORTER ZINC TRANSPORTER ZIP11 metal ion transmembrane transporter activity#GO:0046873;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;zinc ion transmembrane transporter activity#GO:0005385;transition metal ion transmembrane transporter activity#GO:0046915 monoatomic ion transmembrane transport#GO:0034220;zinc ion transport#GO:0006829;monoatomic cation transmembrane transport#GO:0098655;cellular process#GO:0009987;import into cell#GO:0098657;establishment of localization#GO:0051234;inorganic cation import across plasma membrane#GO:0098659;transport#GO:0006810;import across plasma membrane#GO:0098739;inorganic ion import across plasma membrane#GO:0099587;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;transition metal ion transport#GO:0000041;zinc ion transmembrane transport#GO:0071577 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;plasma membrane#GO:0005886;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 secondary carrier transporter#PC00258 HUMAN|HGNC=30826|UniProtKB=Q86UY8 Q86UY8 NT5DC3 PTHR12103:SF11 5'-NUCLEOTIDASE DOMAIN-CONTAINING 5'-NUCLEOTIDASE DOMAIN-CONTAINING PROTEIN 3 phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578 phosphatase#PC00181;nucleotide phosphatase#PC00173;hydrolase#PC00121 HUMAN|HGNC=29063|UniProtKB=Q5VV63 Q5VV63 ATRNL1 PTHR24044:SF487 NOTCH LIGAND FAMILY MEMBER ATTRACTIN-LIKE PROTEIN 1 protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 intercellular signal molecule#PC00207 HUMAN|HGNC=2313|UniProtKB=P22792 P22792 CPN2 PTHR24373:SF271 SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN CARBOXYPEPTIDASE N SUBUNIT 2 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=11934|UniProtKB=P23510 P23510 TNFSF4 PTHR17534:SF4 OX40 LIGAND TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 4 protein binding#GO:0005515;molecular function activator activity#GO:0140677;binding#GO:0005488;cytokine receptor binding#GO:0005126;signaling receptor binding#GO:0005102;tumor necrosis factor receptor superfamily binding#GO:0032813;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018 regulation of cytokine production#GO:0001817;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of cellular process#GO:0048522;regulation of cell adhesion#GO:0030155;regulation of lymphocyte proliferation#GO:0050670;positive regulation of leukocyte cell-cell adhesion#GO:1903039;biological regulation#GO:0065007;positive regulation of cell activation#GO:0050867;positive regulation of leukocyte proliferation#GO:0070665;regulation of leukocyte cell-cell adhesion#GO:1903037;regulation of biosynthetic process#GO:0009889;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;defense response#GO:0006952;positive regulation of cell adhesion#GO:0045785;regulation of T cell proliferation#GO:0042129;regulation of macromolecule metabolic process#GO:0060255;regulation of immune system process#GO:0002682;regulation of cell-cell adhesion#GO:0022407;regulation of cellular process#GO:0050794;positive regulation of cytokine production#GO:0001819;inflammatory response#GO:0006954;positive regulation of lymphocyte proliferation#GO:0050671;positive regulation of biosynthetic process#GO:0009891;regulation of cell population proliferation#GO:0042127;positive regulation of lymphocyte activation#GO:0051251;positive regulation of cell-cell adhesion#GO:0022409;positive regulation of immune system process#GO:0002684;regulation of mononuclear cell proliferation#GO:0032944;response to stress#GO:0006950;positive regulation of biological process#GO:0048518;positive regulation of T cell activation#GO:0050870;positive regulation of macromolecule metabolic process#GO:0010604;regulation of T cell activation#GO:0050863;regulation of multicellular organismal process#GO:0051239;positive regulation of leukocyte activation#GO:0002696;regulation of leukocyte proliferation#GO:0070663;positive regulation of mononuclear cell proliferation#GO:0032946;regulation of leukocyte activation#GO:0002694;positive regulation of cell population proliferation#GO:0008284;regulation of biological process#GO:0050789;positive regulation of multicellular organismal process#GO:0051240;regulation of cell activation#GO:0050865;response to stimulus#GO:0050896;positive regulation of T cell proliferation#GO:0042102;regulation of lymphocyte activation#GO:0051249;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=27564|UniProtKB=Q2TAC2 Q2TAC2 CCDC57 PTHR46725:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 57 COILED-COIL DOMAIN-CONTAINING PROTEIN 57 cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;positive regulation of cell cycle#GO:0045787;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cell projection assembly#GO:0030031;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;microtubule organizing center organization#GO:0031023;microtubule-based process#GO:0007017;centrosome duplication#GO:0051298;protein-containing complex organization#GO:0043933;cell projection organization#GO:0030030;regulation of cell cycle#GO:0051726;microtubule nucleation#GO:0007020;membraneless organelle assembly#GO:0140694;cilium assembly#GO:0060271;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;centrosome cycle#GO:0007098;protein polymerization#GO:0051258;protein-containing complex assembly#GO:0065003;cell cycle process#GO:0022402;cilium organization#GO:0044782;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;microtubule polymerization or depolymerization#GO:0031109;positive regulation of cellular process#GO:0048522;regulation of mitotic cell cycle#GO:0007346;positive regulation of mitotic cell cycle#GO:0045931;microtubule polymerization#GO:0046785;plasma membrane bounded cell projection assembly#GO:0120031;regulation of cellular process#GO:0050794;cell cycle#GO:0007049;microtubule cytoskeleton organization#GO:0000226;supramolecular fiber organization#GO:0097435;organelle assembly#GO:0070925;centriole replication#GO:0007099 membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;spindle#GO:0005819;centrosome#GO:0005813;centriole#GO:0005814;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;microtubule cytoskeleton#GO:0015630;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;spindle microtubule#GO:0005876;microtubule#GO:0005874;intracellular organelle#GO:0043229;centriolar satellite#GO:0034451;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=31700|UniProtKB=A1YPR0 A1YPR0 ZBTB7C PTHR46105:SF7 AGAP004733-PA ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 7C sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987 regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=37094|UniProtKB=P0CG39 P0CG39 POTEJ PTHR11937:SF547 ACTIN POTE ANKYRIN DOMAIN FAMILY MEMBER E-RELATED structural molecule activity#GO:0005198;structural constituent of synapse#GO:0098918;protein binding#GO:0005515;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;binding#GO:0005488;structural constituent of cytoskeleton#GO:0005200;kinase binding#GO:0019900 cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cell morphogenesis#GO:0000902;cell motility#GO:0048870;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell development#GO:0048468;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;anatomical structure development#GO:0048856;axonogenesis#GO:0007409;neuron development#GO:0048666;system development#GO:0048731;axon development#GO:0061564;neuron projection development#GO:0031175;cellular process#GO:0009987;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cell morphogenesis involved in neuron differentiation#GO:0048667;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;neuron differentiation#GO:0030182;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;neurogenesis#GO:0022008;cell projection morphogenesis#GO:0048858 histone acetyltransferase complex#GO:0000123;cell junction#GO:0030054;actin filament#GO:0005884;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;NuA4 histone acetyltransferase complex#GO:0035267;supramolecular complex#GO:0099080;chromatin#GO:0000785;neuron projection#GO:0043005;supramolecular fiber#GO:0099512;acetyltransferase complex#GO:1902493;protein acetyltransferase complex#GO:0031248;intracellular organelle#GO:0043229;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;actin cytoskeleton#GO:0015629;intracellular protein-containing complex#GO:0140535;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;transferase complex#GO:1990234;cytoskeleton#GO:0005856;H4 histone acetyltransferase complex#GO:1902562;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;axon#GO:0030424;catalytic complex#GO:1902494;plasma membrane bounded cell projection#GO:0120025;chromosome#GO:0005694 actin and actin related protein#PC00039 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>F-actin#P00858;Alzheimer disease-presenilin pathway#P00004>actin#P00114;Nicotinic acetylcholine receptor signaling pathway#P00044>Actin#P01090;Cytoskeletal regulation by Rho GTPase#P00016>Actin#P00512;Cadherin signaling pathway#P00012>F-actin#P00470;Huntington disease#P00029>Actin#P00807;Integrin signalling pathway#P00034>Actin#P00944 HUMAN|HGNC=28550|UniProtKB=Q6ZUK4 Q6ZUK4 TMEM26 PTHR22168:SF3 TMEM26 PROTEIN TRANSMEMBRANE PROTEIN 26 HUMAN|HGNC=14339|UniProtKB=Q9H4M7 Q9H4M7 PLEKHA4 PTHR12752:SF7 PHOSPHOINOSITOL 3-PHOSPHATE-BINDING PROTEIN PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 4 anion binding#GO:0043168;small molecule binding#GO:0036094;binding#GO:0005488;phosphatidylinositol-4,5-bisphosphate binding#GO:0005546;ion binding#GO:0043167;lipid binding#GO:0008289;phosphatidylinositol bisphosphate binding#GO:1902936;phospholipid binding#GO:0005543;phosphatidylinositol-3-phosphate binding#GO:0032266;phosphatidylinositol phosphate binding#GO:1901981 regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;positive regulation of Wnt signaling pathway#GO:0030177;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of canonical Wnt signaling pathway#GO:0060828;positive regulation of canonical Wnt signaling pathway#GO:0090263;regulation of response to stimulus#GO:0048583;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051 cytoplasmic side of membrane#GO:0098562;extrinsic component of cytoplasmic side of plasma membrane#GO:0031234;extrinsic component of plasma membrane#GO:0019897;side of membrane#GO:0098552;extrinsic component of membrane#GO:0019898;cell periphery#GO:0071944;membrane#GO:0016020;cytoplasmic side of plasma membrane#GO:0009898;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 HUMAN|HGNC=29806|UniProtKB=Q8N386 Q8N386 LRRC25 PTHR20878:SF0 LEUCINE-RICH REPEAT CONTAINING PROTEIN 25 LEUCINE-RICH REPEAT-CONTAINING PROTEIN 25 HUMAN|HGNC=27843|UniProtKB=Q5JU67 Q5JU67 CFAP157 PTHR31954:SF2 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 157 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 157 cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;microtubule binding#GO:0008017;binding#GO:0005488;protein binding#GO:0005515 cellular developmental process#GO:0048869;sperm axoneme assembly#GO:0007288;flagellated sperm motility#GO:0030317;plasma membrane bounded cell projection assembly#GO:0120031;developmental process#GO:0032502;spermatogenesis#GO:0007283;male gamete generation#GO:0048232;plasma membrane bounded cell projection organization#GO:0120036;anatomical structure development#GO:0048856;microtubule cytoskeleton organization#GO:0000226;axoneme assembly#GO:0035082;multicellular organismal reproductive process#GO:0048609;organelle assembly#GO:0070925;sexual reproduction#GO:0019953;microtubule bundle formation#GO:0001578;spermatid development#GO:0007286;cell motility#GO:0048870;microtubule-based movement#GO:0007018;reproductive process#GO:0022414;developmental process involved in reproduction#GO:0003006;germ cell development#GO:0007281;motile cilium assembly#GO:0044458;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cilium movement involved in cell motility#GO:0060294;cell projection assembly#GO:0030031;cellular process#GO:0009987;sperm flagellum assembly#GO:0120316;cilium-dependent cell motility#GO:0060285;cilium organization#GO:0044782;spermatid differentiation#GO:0048515;cilium or flagellum-dependent cell motility#GO:0001539;cilium movement#GO:0003341;cell differentiation#GO:0030154;cell projection organization#GO:0030030;gamete generation#GO:0007276;cell development#GO:0048468;cellular process involved in reproduction in multicellular organism#GO:0022412;cellular component organization#GO:0016043;cilium assembly#GO:0060271;sperm motility#GO:0097722 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;microtubule organizing center#GO:0005815;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;cilium#GO:0005929 structural protein#PC00211 HUMAN|HGNC=9845|UniProtKB=O60896 O60896 RAMP3 PTHR14076:SF2 RECEPTOR ACTIVITY MODIFYING PROTEIN RAMP RECEPTOR ACTIVITY-MODIFYING PROTEIN 3 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;coreceptor activity#GO:0015026 macromolecule localization#GO:0033036;biological regulation#GO:0065007;transport#GO:0006810;intracellular protein localization#GO:0008104;receptor-mediated endocytosis#GO:0006898;establishment of localization#GO:0051234;cellular response to stimulus#GO:0051716;protein localization to plasma membrane#GO:0072659;metal ion transport#GO:0030001;regulation of cellular process#GO:0050794;localization within membrane#GO:0051668;cell communication#GO:0007154;monoatomic cation transport#GO:0006812;localization#GO:0051179;cellular process#GO:0009987;establishment of protein localization#GO:0045184;signal transduction#GO:0007165;response to hormone#GO:0009725;receptor internalization#GO:0031623;vesicle-mediated transport#GO:0016192;response to chemical#GO:0042221;protein localization to cell periphery#GO:1990778;calcium ion transport#GO:0006816;import into cell#GO:0098657;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;protein localization to membrane#GO:0072657;signaling#GO:0023052;endocytosis#GO:0006897;cellular response to hormone stimulus#GO:0032870;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887;protein transport#GO:0015031;monoatomic ion transport#GO:0006811;cellular localization#GO:0051641 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cell surface#GO:0009986;signaling receptor complex#GO:0043235 transmembrane signal receptor#PC00197 HUMAN|HGNC=29154|UniProtKB=Q9Y2F5 Q9Y2F5 ICE1 PTHR11852:SF4 PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE LITTLE ELONGATION COMPLEX SUBUNIT 1 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 snRNA transcription#GO:0009301;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;snRNA transcription by RNA polymerase II#GO:0042795;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;transcription by RNA polymerase III#GO:0006383;snRNA metabolic process#GO:0016073;RNA metabolic process#GO:0016070;snRNA transcription by RNA polymerase III#GO:0042796;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;transcription by RNA polymerase II#GO:0006366 nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;protein-containing complex#GO:0032991;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;transcription elongation factor complex#GO:0008023;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634 protein modifying enzyme#PC00260 HUMAN|HGNC=12270|UniProtKB=Q9BQ50 Q9BQ50 TREX2 PTHR13058:SF24 THREE PRIME REPAIR EXONUCLEASE 1, 2 THREE PRIME REPAIR EXONUCLEASE 2 catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity, acting on ester bonds#GO:0016788;DNA nuclease activity#GO:0004536;DNA exonuclease activity#GO:0004529;catalytic activity, acting on DNA#GO:0140097;3'-5' exonuclease activity#GO:0008408;exonuclease activity#GO:0004527;hydrolase activity#GO:0016787;3'-5'-DNA exonuclease activity#GO:0008296;DNA exonuclease activity, producing 5'-phosphomonoesters#GO:0016895;nuclease activity#GO:0004518 nucleobase-containing compound catabolic process#GO:0034655;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;nucleic acid catabolic process#GO:0141188;cellular process#GO:0009987;catabolic process#GO:0009056;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;DNA catabolic process#GO:0006308;macromolecule catabolic process#GO:0009057;DNA metabolic process#GO:0006259;macromolecule metabolic process#GO:0043170 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 Ubiquitin proteasome pathway#P00060>26S proteasome#P01489 HUMAN|HGNC=3691|UniProtKB=P22455 P22455 FGFR4 PTHR24416:SF343 TYROSINE-PROTEIN KINASE RECEPTOR FIBROBLAST GROWTH FACTOR RECEPTOR 4 catalytic activity, acting on a protein#GO:0140096;transmembrane receptor protein kinase activity#GO:0019199;protein tyrosine kinase activity#GO:0004713;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;transmembrane receptor protein tyrosine kinase activity#GO:0004714;molecular transducer activity#GO:0060089;fibroblast growth factor binding#GO:0017134;signaling receptor activity#GO:0038023;transferase activity#GO:0016740;kinase activity#GO:0016301;protein binding#GO:0005515;phosphotransferase activity, alcohol group as acceptor#GO:0016773;growth factor binding#GO:0019838;protein kinase activity#GO:0004672;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888 biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of lipid biosynthetic process#GO:0046890;positive regulation of response to stimulus#GO:0048584;fibroblast growth factor receptor signaling pathway#GO:0008543;regulation of steroid biosynthetic process#GO:0050810;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;positive regulation of MAPK cascade#GO:0043410;regulation of biosynthetic process#GO:0009889;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;response to fibroblast growth factor#GO:0071774;positive regulation of ERK1 and ERK2 cascade#GO:0070374;regulation of cell communication#GO:0010646;response to growth factor#GO:0070848;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;enzyme-linked receptor protein signaling pathway#GO:0007167;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of lipid metabolic process#GO:0019216;regulation of ERK1 and ERK2 cascade#GO:0070372;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;cellular response to fibroblast growth factor stimulus#GO:0044344;regulation of MAPK cascade#GO:0043408;cell surface receptor signaling pathway#GO:0007166;signaling#GO:0023052;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;positive regulation of cell population proliferation#GO:0008284;cellular response to growth factor stimulus#GO:0071363;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531 signaling receptor complex#GO:0043235;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 transmembrane signal receptor#PC00197 FGF signaling pathway#P00021>FGFR1-4#P00636 HUMAN|HGNC=26025|UniProtKB=Q9NX47 Q9NX47 MARCHF5 PTHR46283:SF4 E3 UBIQUITIN-PROTEIN LIGASE MARCH5 E3 UBIQUITIN-PROTEIN LIGASE MARCHF5 acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 regulation of organelle organization#GO:0033043;regulation of mitochondrion organization#GO:0010821;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;regulation of biological process#GO:0050789;primary metabolic process#GO:0044238;protein modification process#GO:0036211;regulation of developmental process#GO:0050793;regulation of mitochondrial fission#GO:0090140;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;protein modification by small protein conjugation or removal#GO:0070647;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;cellular process#GO:0009987;post-translational protein modification#GO:0043687;biological regulation#GO:0065007;protein ubiquitination#GO:0016567;metabolic process#GO:0008152;regulation of anatomical structure morphogenesis#GO:0022603;macromolecule metabolic process#GO:0043170 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;outer membrane#GO:0019867;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;mitochondrion#GO:0005739;mitochondrial outer membrane#GO:0005741;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;organelle outer membrane#GO:0031968;cytoplasm#GO:0005737;membrane#GO:0016020;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=13586|UniProtKB=Q9Y3I1 Q9Y3I1 FBXO7 PTHR15537:SF2 F-BOX ONLY PROTEIN 7 F-BOX ONLY PROTEIN 7 HUMAN|HGNC=977|UniProtKB=O15382 O15382 BCAT2 PTHR11825:SF39 SUBGROUP IIII AMINOTRANSFERASE BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, MITOCHONDRIAL catalytic activity#GO:0003824;transferase activity#GO:0016740;transaminase activity#GO:0008483 metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;proteinogenic amino acid metabolic process#GO:0170039;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;amino acid metabolic process#GO:0006520;small molecule catabolic process#GO:0044282;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 transaminase#PC00216;transferase#PC00220 Alanine biosynthesis#P02724>Branched chain amino acid aminotransferase#P02815;Leucine biosynthesis#P02749>Branched chain amino acid aminotransferase#P03000;Isoleucine biosynthesis#P02748>Branched chain amino acid aminotransferase#P02994;Valine biosynthesis#P02785>Branched chain amino acid aminotransferase#P03215 HUMAN|HGNC=29680|UniProtKB=Q8TBP6 Q8TBP6 SLC25A40 PTHR45760:SF5 FI19922P1-RELATED MITOCHONDRIAL GLUTATHIONE TRANSPORTER SLC25A40 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=8247|UniProtKB=O95006 O95006 OR2F2 PTHR26453:SF63 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2F2 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;sensory perception#GO:0007600;nervous system process#GO:0050877;system process#GO:0003008;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;detection of chemical stimulus#GO:0009593;response to chemical#GO:0042221;response to stimulus#GO:0050896;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=14417|UniProtKB=Q96BH3 Q96BH3 ELSPBP1 PTHR22918:SF2 SEMINAL PLASMA PROTEIN EPIDIDYMAL SPERM-BINDING PROTEIN 1 multicellular organismal reproductive process#GO:0048609;anatomical structure development#GO:0048856;spermatid development#GO:0007286;sexual reproduction#GO:0019953;spermatid differentiation#GO:0048515;cell development#GO:0048468;cellular process involved in reproduction in multicellular organism#GO:0022412;reproductive process#GO:0022414;gamete generation#GO:0007276;cell differentiation#GO:0030154;germ cell development#GO:0007281;anatomical structure maturation#GO:0071695;developmental process involved in reproduction#GO:0003006;cellular developmental process#GO:0048869;cell maturation#GO:0048469;developmental process#GO:0032502;spermatogenesis#GO:0007283;sperm capacitation#GO:0048240;male gamete generation#GO:0048232;developmental maturation#GO:0021700;cellular process#GO:0009987 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|Ensembl=ENSG00000283984.2|UniProtKB=A0AB56HXB4 A0AB56HXB4 PTHR11667:SF27 FAMILY NOT NAMED ADENYLATE KINASE HUMAN|HGNC=15992|UniProtKB=Q9BYN7 Q9BYN7 ZNF341 PTHR24388:SF28 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 341 double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=20753|UniProtKB=Q96G79 Q96G79 SLC35A4 PTHR10231:SF109 NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER UDP-SUGAR TRANSPORTER PROTEIN SLC35A4-RELATED transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 transport#GO:0006810;cellular process#GO:0009987;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179 membrane#GO:0016020;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622 transporter#PC00227 HUMAN|HGNC=11630|UniProtKB=P35680 P35680 HNF1B PTHR11568:SF2 HEPATOCYTE NUCLEAR FACTOR 1 HEPATOCYTE NUCLEAR FACTOR 1-BETA sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119 HUMAN|HGNC=12860|UniProtKB=O43829 O43829 ZBTB14 PTHR24399:SF5 ZINC FINGER AND BTB DOMAIN-CONTAINING ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 14 sequence-specific double-stranded DNA binding#GO:1990837;nucleic acid binding#GO:0003676;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulator activity#GO:0140110;DNA-binding transcription repressor activity#GO:0001217;transcription regulatory region nucleic acid binding#GO:0001067 negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of cytokine production#GO:0001817;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165 C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218 HUMAN|HGNC=15989|UniProtKB=Q8NEY1 Q8NEY1 NAV1 PTHR12784:SF3 STEERIN NEURON NAVIGATOR 1 nervous system development#GO:0007399;cytoskeleton organization#GO:0007010;multicellular organismal process#GO:0032501;cell migration#GO:0016477;cellular process#GO:0009987;organelle organization#GO:0006996;microtubule-based process#GO:0007017;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;neuron migration#GO:0001764;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;developmental process#GO:0032502;cell motility#GO:0048870;cell differentiation#GO:0030154;cellular component organization#GO:0016043;system development#GO:0048731;anatomical structure development#GO:0048856;microtubule cytoskeleton organization#GO:0000226;microtubule bundle formation#GO:0001578;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;axon#GO:0030424;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;microtubule cytoskeleton#GO:0015630;main axon#GO:0044304;neuron projection#GO:0043005;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025 HUMAN|HGNC=26258|UniProtKB=Q8WWF1 Q8WWF1 C1orf54 PTHR37870:SF1 CHROMOSOME 1 OPEN READING FRAME 54 SIMILAR TO HUMAN CHROMOSOME 1 OPEN READING FRAME 54 HUMAN|HGNC=28654|UniProtKB=Q8IYP9 Q8IYP9 ZDHHC23 PTHR22883:SF475 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE ZDHHC23 acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;palmitoyltransferase activity#GO:0016409;catalytic activity, acting on a protein#GO:0140096 protein targeting#GO:0006605;macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657;establishment of protein localization to membrane#GO:0090150;protein localization to plasma membrane#GO:0072659;establishment of protein localization#GO:0045184;cellular process#GO:0009987;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;intracellular protein localization#GO:0008104;protein localization to cell periphery#GO:1990778;protein targeting to membrane#GO:0006612;localization within membrane#GO:0051668 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 protein modifying enzyme#PC00260 HUMAN|HGNC=13583|UniProtKB=Q9UKT5 Q9UKT5 FBXO4 PTHR16008:SF4 F-BOX ONLY PROTEIN 4 F-BOX ONLY PROTEIN 4 primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;protein polyubiquitination#GO:0000209;catabolic process#GO:0009056;protein modification by small protein conjugation or removal#GO:0070647;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;cellular process#GO:0009987;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;proteasomal protein catabolic process#GO:0010498;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511 ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535;SCF ubiquitin ligase complex#GO:0019005;transferase complex#GO:1990234;catalytic complex#GO:1902494 HUMAN|HGNC=1268|UniProtKB=Q8WU66 Q8WU66 TSPEAR PTHR15261:SF4 THROMBOSPONDIN-TYPE LAMININ G DOMAIN AND EAR REPEAT-CONTAINING THROMBOSPONDIN-TYPE LAMININ G DOMAIN AND EAR REPEAT-CONTAINING PROTEIN cell communication#GO:0007154;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 intercellular signal molecule#PC00207 HUMAN|HGNC=10496|UniProtKB=P06703 P06703 S100A6 PTHR11639:SF80 S100 CALCIUM-BINDING PROTEIN PROTEIN S100-A6 cation binding#GO:0043169;protein binding#GO:0005515;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094 nucleus#GO:0005634;perinuclear region of cytoplasm#GO:0048471;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 calcium-binding protein#PC00060;calmodulin-related#PC00061 HUMAN|HGNC=9529|UniProtKB=P11801 P11801 PSKH1 PTHR24347:SF254 SERINE/THREONINE-PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE H1 catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;cell communication#GO:0007154 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=17943|UniProtKB=Q9GZP9 Q9GZP9 DERL2 PTHR11009:SF5 DER1-LIKE PROTEIN, DERLIN DERLIN-2 cellular process#GO:0009987;signal transduction#GO:0007165;endoplasmic reticulum unfolded protein response#GO:0030968;response to stress#GO:0006950;proteasomal protein catabolic process#GO:0010498;biological regulation#GO:0065007;response to chemical#GO:0042221;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;primary metabolic process#GO:0044238;signaling#GO:0023052;response to topologically incorrect protein#GO:0035966;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;catabolic process#GO:0009056;cellular response to topologically incorrect protein#GO:0035967;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;response to endoplasmic reticulum stress#GO:0034976;cellular response to unfolded protein#GO:0034620;intracellular signal transduction#GO:0035556;ERAD pathway#GO:0036503;protein metabolic process#GO:0019538;cell communication#GO:0007154;response to unfolded protein#GO:0006986 endoplasmic reticulum membrane#GO:0005789;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane#GO:0016020;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 primary active transporter#PC00068;transporter#PC00227 HUMAN|HGNC=14965|UniProtKB=Q9BY71 Q9BY71 LRRC3 PTHR24369:SF170 ANTIGEN BSP, PUTATIVE-RELATED LEUCINE-RICH REPEAT-CONTAINING PROTEIN 3 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 cell adhesion molecule#PC00069 HUMAN|HGNC=51|UniProtKB=P33527 P33527 ABCC1 PTHR24223:SF241 ATP-BINDING CASSETTE SUB-FAMILY C MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1 xenobiotic transmembrane transporter activity#GO:0042910;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626;carboxylic acid transmembrane transporter activity#GO:0046943;active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399;transmembrane transporter activity#GO:0022857;tripeptide transmembrane transporter activity#GO:0042937;transporter activity#GO:0005215;oligopeptide transmembrane transporter activity#GO:0035673 cellular process#GO:0009987;oligopeptide transmembrane transport#GO:0035672;nitrogen compound transport#GO:0071705;peptide transport#GO:0015833;transport#GO:0006810;xenobiotic transport#GO:0042908;oligopeptide transport#GO:0006857;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 ATP-binding cassette (ABC) transporter#PC00003 HUMAN|HGNC=12836|UniProtKB=Q9H0D6 Q9H0D6 XRN2 PTHR12341:SF41 5'->3' EXORIBONUCLEASE 5'-3' EXORIBONUCLEASE 2 nucleic acid binding#GO:0003676;binding#GO:0005488;exonuclease activity#GO:0004527;hydrolase activity#GO:0016787;RNA binding#GO:0003723;5'-3' exonuclease activity#GO:0008409;nuclease activity#GO:0004518;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on RNA#GO:0140098;RNA nuclease activity#GO:0004540 biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;mRNA catabolic process#GO:0006402;nucleobase-containing compound catabolic process#GO:0034655;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleic acid catabolic process#GO:0141188;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;macromolecule metabolic process#GO:0043170;regulation of gene expression#GO:0010468;macromolecule catabolic process#GO:0009057;negative regulation of cellular process#GO:0048523;metabolic process#GO:0008152;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;nucleic acid metabolic process#GO:0090304;negative regulation of gene expression#GO:0010629;primary metabolic process#GO:0044238;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;RNA metabolic process#GO:0016070;RNA catabolic process#GO:0006401 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 RNA metabolism protein#PC00031;exoribonuclease#PC00099 DNA replication#P00017>5' to 3' Exoribonulcease#P00535 HUMAN|HGNC=3288|UniProtKB=Q13541 Q13541 EIF4EBP1 PTHR12669:SF14 EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1 translation regulator activity#GO:0045182;protein binding#GO:0005515;translation initiation factor binding#GO:0031369;binding#GO:0005488 negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of translational initiation#GO:0006446;negative regulation of translation#GO:0017148;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 translation factor#PC00223;translation initiation factor#PC00224 p53 pathway by glucose deprivation#P04397>4E-BP1#P04637;p38 MAPK pathway#P05918>4E-BP1#P06042;CCKR signaling map#P06959>4E-BP1#P07230 HUMAN|HGNC=20922|UniProtKB=Q9BQ83 Q9BQ83 SLX1A PTHR20208:SF10 STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1 STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1 catalytic activity, acting on DNA#GO:0140097;endonuclease activity#GO:0004519;catalytic activity#GO:0003824;DNA endonuclease activity, producing 5'-phosphomonoesters#GO:0016888;catalytic activity, acting on a nucleic acid#GO:0140640;DNA nuclease activity#GO:0004536;hydrolase activity, acting on ester bonds#GO:0016788;DNA endonuclease activity#GO:0004520;hydrolase activity#GO:0016787;nuclease activity#GO:0004518 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;double-strand break repair via homologous recombination#GO:0000724;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;recombinational repair#GO:0000725;cellular response to stress#GO:0033554;response to stress#GO:0006950;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA damage response#GO:0006974;DNA recombination#GO:0006310;macromolecule metabolic process#GO:0043170;double-strand break repair#GO:0006302 membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;chromosome#GO:0005694;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226 DNA metabolism protein#PC00009;endodeoxyribonuclease#PC00093 Transcription regulation by bZIP transcription factor#P00055>RNA Polymerase II#P01388 HUMAN|HGNC=17022|UniProtKB=Q9UPZ3 Q9UPZ3 HPS5 PTHR23287:SF18 RUBY-EYE2-LIKE PROTEIN BLOC-2 COMPLEX MEMBER HPS5 pigmentation#GO:0043473;developmental pigmentation#GO:0048066 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=30522|UniProtKB=Q8N4P3 Q8N4P3 HDDC3 PTHR46246:SF1 GUANOSINE-3',5'-BIS(DIPHOSPHATE) 3'-PYROPHOSPHOHYDROLASE MESH1 GUANOSINE-3',5'-BIS(DIPHOSPHATE) 3'-PYROPHOSPHOHYDROLASE MESH1 hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788 hydrolase#PC00121 HUMAN|HGNC=29585|UniProtKB=Q8N6V9 Q8N6V9 TEX9 PTHR23313:SF0 TSEC1-RELATED TESTIS-EXPRESSED PROTEIN 9 actin binding motor protein#PC00040;actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=14210|UniProtKB=Q9UH99 Q9UH99 SUN2 PTHR12911:SF22 SAD1/UNC-84-LIKE PROTEIN-RELATED SUN DOMAIN-CONTAINING PROTEIN 2 protein-membrane adaptor activity#GO:0043495;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 nucleus#GO:0005634;membrane#GO:0016020;membrane protein complex#GO:0098796;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=18233|UniProtKB=Q8NDB2 Q8NDB2 BANK1 PTHR16267:SF13 BANK1/PIK3AP1 FAMILY MEMBER B-CELL SCAFFOLD PROTEIN WITH ANKYRIN REPEATS binding#GO:0005488;kinase binding#GO:0019900;protein tyrosine kinase binding#GO:1990782;signaling receptor binding#GO:0005102;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;protein binding#GO:0005515 regulation of lymphocyte activation#GO:0051249;regulation of cell activation#GO:0050865;regulation of biological process#GO:0050789;regulation of leukocyte activation#GO:0002694;negative regulation of biological process#GO:0048519;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;immune system process#GO:0002376;negative regulation of lymphocyte activation#GO:0051250;regulation of multicellular organismal process#GO:0051239;negative regulation of signal transduction#GO:0009968;negative regulation of leukocyte activation#GO:0002695;lymphocyte activation#GO:0046649;cellular process#GO:0009987;regulation of B cell activation#GO:0050864;B cell activation#GO:0042113;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;leukocyte activation#GO:0045321;negative regulation of multicellular organismal process#GO:0051241;regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051896;cell activation#GO:0001775;biological regulation#GO:0065007;negative regulation of immune system process#GO:0002683;regulation of signal transduction#GO:0009966;negative regulation of response to stimulus#GO:0048585;multicellular organismal process#GO:0032501;negative regulation of cell activation#GO:0050866;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523 HUMAN|HGNC=21240|UniProtKB=Q8N878 Q8N878 FRMD1 PTHR13429:SF7 FERM DOMAIN (PROTEIN4.1-EZRIN-RADIXIN-MOESIN) FAMILY FERM DOMAIN-CONTAINING PROTEIN 1 protein sequestering activity#GO:0140311;molecular sequestering activity#GO:0140313 regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;regulation of cell communication#GO:0010646;regulation of hippo signaling#GO:0035330;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531 plasma membrane#GO:0005886;anchoring junction#GO:0070161;cell junction#GO:0030054;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;cell-cell junction#GO:0005911;membrane#GO:0016020 HUMAN|HGNC=29909|UniProtKB=Q96AB6 Q96AB6 NTAN1 PTHR12498:SF0 N-TERMINAL ASPARAGINE AMIDOHYDROLASE PROTEIN N-TERMINAL ASPARAGINE AMIDOHYDROLASE catalytic activity, acting on a protein#GO:0140096;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811 protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238;catabolic process#GO:0009056 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 protein modifying enzyme#PC00260 HUMAN|HGNC=21602|UniProtKB=Q9NU19 Q9NU19 TBC1D22B PTHR22957:SF462 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN TBC1 DOMAIN FAMILY MEMBER 22B enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 GTPase-activating protein#PC00257;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HUMAN|HGNC=17717|UniProtKB=Q9UEW8 Q9UEW8 STK39 PTHR48012:SF14 STERILE20-LIKE KINASE, ISOFORM B-RELATED STE20_SPS1-RELATED PROLINE-ALANINE-RICH PROTEIN KINASE protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;regulation of cell motility#GO:2000145;positive regulation of chemotaxis#GO:0050921;regulation of lymphocyte migration#GO:2000401;cellular response to osmotic stress#GO:0071470;hyperosmotic response#GO:0006972;regulation of leukocyte migration#GO:0002685;cellular response to environmental stimulus#GO:0104004;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;cellular response to stimulus#GO:0051716;positive regulation of locomotion#GO:0040017;response to osmotic stress#GO:0006970;regulation of cell migration#GO:0030334;regulation of response to stimulus#GO:0048583;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;positive regulation of response to stimulus#GO:0048584;positive regulation of cellular process#GO:0048522;positive regulation of cell migration#GO:0030335;cellular response to stress#GO:0033554;cellular response to chemical stimulus#GO:0070887;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;positive regulation of cell motility#GO:2000147;regulation of chemotaxis#GO:0050920;response to abiotic stimulus#GO:0009628;cellular response to chemical stress#GO:0062197;positive regulation of response to external stimulus#GO:0032103;cellular response to abiotic stimulus#GO:0071214;response to chemical#GO:0042221;regulation of response to external stimulus#GO:0032101;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;positive regulation of immune system process#GO:0002684;response to stress#GO:0006950 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=492|UniProtKB=P16157 P16157 ANK1 PTHR24133:SF38 ANKYRIN DOMAIN-CONTAINING ANKYRIN-1 molecular adaptor activity#GO:0060090;cytoskeletal adaptor activity#GO:0008093;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;transmembrane transporter binding#GO:0044325 macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657;protein localization to plasma membrane#GO:0072659;cellular process#GO:0009987;protein localization to cell periphery#GO:1990778;localization within membrane#GO:0051668;localization#GO:0051179;cellular localization#GO:0051641;intracellular protein localization#GO:0008104 membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005;cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HUMAN|HGNC=375|UniProtKB=P24588 P24588 AKAP5 PTHR15182:SF0 A-KINASE ANCHOR PROTEIN 5-RELATED A-KINASE ANCHOR PROTEIN 5 G protein-coupled receptor binding#GO:0001664;protein kinase A binding#GO:0051018;GABA receptor binding#GO:0050811;protein binding#GO:0005515;enzyme binding#GO:0019899;protein kinase A regulatory subunit binding#GO:0034237;signaling receptor binding#GO:0005102;binding#GO:0005488 neuron to neuron synapse#GO:0098984;plasma membrane region#GO:0098590;postsynaptic specialization#GO:0099572;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;membrane#GO:0016020;cell leading edge#GO:0031252;cell periphery#GO:0071944;neuron projection#GO:0043005;cell junction#GO:0030054;neuron projection membrane#GO:0032589;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;asymmetric synapse#GO:0032279;neuron spine#GO:0044309;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;postsynapse#GO:0098794;dendritic spine#GO:0043197;cell projection membrane#GO:0031253;dendrite#GO:0030425;postsynaptic density#GO:0014069;leading edge membrane#GO:0031256;dendritic tree#GO:0097447 scaffold/adaptor protein#PC00226 HUMAN|HGNC=6609|UniProtKB=O75023 O75023 LILRB5 PTHR11738:SF108 MHC CLASS I NK CELL RECEPTOR LEUKOCYTE IMMUNOGLOBULIN-LIKE RECEPTOR SUBFAMILY B MEMBER 5 molecular transducer activity#GO:0060089;immune receptor activity#GO:0140375;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 cellular response to stimulus#GO:0051716;immune response-regulating signaling pathway#GO:0002764;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;signaling#GO:0023052;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of immune response#GO:0050776;cytokine-mediated signaling pathway#GO:0019221;response to peptide#GO:1901652;cell communication#GO:0007154;cellular process#GO:0009987;signal transduction#GO:0007165;immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007;response to chemical#GO:0042221;response to cytokine#GO:0034097;regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=15762|UniProtKB=Q9BZJ0 Q9BZJ0 CRNKL1 PTHR11246:SF3 PRE-MRNA SPLICING FACTOR CROOKED NECK-LIKE PROTEIN 1 RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;spliceosomal complex assembly#GO:0000245;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;protein-RNA complex assembly#GO:0022618;cellular component organization#GO:0016043;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;protein-containing complex assembly#GO:0065003;mRNA splicing, via spliceosome#GO:0000398;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;ribonucleoprotein complex biogenesis#GO:0022613;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-RNA complex organization#GO:0071826;protein-containing complex organization#GO:0043933;cellular component biogenesis#GO:0044085;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component assembly#GO:0022607;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139 protein-containing complex#GO:0032991;post-mRNA release spliceosomal complex#GO:0071014;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;catalytic step 2 spliceosome#GO:0071013;organelle#GO:0043226;cellular anatomical structure#GO:0110165;U2-type spliceosomal complex#GO:0005684;intracellular membrane-bounded organelle#GO:0043231;spliceosomal complex#GO:0005681;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Prp19 complex#GO:0000974;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;catalytic complex#GO:1902494 RNA splicing factor#PC00148;RNA processing factor#PC00147 HUMAN|HGNC=16178|UniProtKB=P59826 P59826 BPIFB3 PTHR46019:SF5 BPI FOLD-CONTAINING FAMILY B MEMBER 4-RELATED BPI FOLD-CONTAINING FAMILY B MEMBER 3 HUMAN|HGNC=10820|UniProtKB=O60880 O60880 SH2D1A PTHR46051:SF10 SH2 DOMAIN-CONTAINING PROTEIN SH2 DOMAIN-CONTAINING PROTEIN 1A regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;regulation of biological process#GO:0050789;regulation of immune response#GO:0050776;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583 HUMAN|HGNC=26068|UniProtKB=Q6IAA8 Q6IAA8 LAMTOR1 PTHR13401:SF2 RAGULATOR COMPLEX PROTEIN LAMTOR1 RAGULATOR COMPLEX PROTEIN LAMTOR1 guanyl-nucleotide exchange factor activity#GO:0005085;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 regulation of response to stimulus#GO:0048583;regulation of MAPK cascade#GO:0043408;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of MAPK cascade#GO:0043410;regulation of metabolic process#GO:0019222;cellular process#GO:0009987;response to acid chemical#GO:0001101;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of response to stimulus#GO:0048584;response to chemical#GO:0042221;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of intracellular signal transduction#GO:1902531;cellular response to chemical stimulus#GO:0070887;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;cellular response to amino acid stimulus#GO:0071230;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;regulation of cell communication#GO:0010646 guanyl-nucleotide exchange factor complex#GO:0032045;protein-containing complex#GO:0032991;vacuole#GO:0005773;cytoplasm#GO:0005737;membrane#GO:0016020;lysosomal membrane#GO:0005765;lytic vacuole#GO:0000323;vacuolar membrane#GO:0005774;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;intracellular protein-containing complex#GO:0140535;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;lytic vacuole membrane#GO:0098852;lysosome#GO:0005764;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=1941|UniProtKB=P26374 P26374 CHML PTHR11787:SF9 RAB GDP-DISSOCIATION INHIBITOR RAB PROTEINS GERANYLGERANYLTRANSFERASE COMPONENT A 2 transport#GO:0006810;localization within membrane#GO:0051668;protein targeting to membrane#GO:0006612;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of protein localization to membrane#GO:0090150;vesicle-mediated transport#GO:0016192;protein targeting#GO:0006605 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex#GO:1990234;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HUMAN|HGNC=2349|UniProtKB=Q99941 Q99941 ATF6B PTHR46164:SF2 ATF6, ISOFORM C CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-6 BETA RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 cellular response to topologically incorrect protein#GO:0035967;cellular response to stress#GO:0033554;response to endoplasmic reticulum stress#GO:0034976;cellular response to unfolded protein#GO:0034620;regulation of RNA metabolic process#GO:0051252;intracellular signal transduction#GO:0035556;regulation of DNA-templated transcription#GO:0006355;cell communication#GO:0007154;response to unfolded protein#GO:0006986;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signaling#GO:0023052;response to topologically incorrect protein#GO:0035966;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular process#GO:0009987;signal transduction#GO:0007165;endoplasmic reticulum unfolded protein response#GO:0030968;regulation of metabolic process#GO:0019222;response to stress#GO:0006950;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 Apoptosis signaling pathway#P00006>ATF#P00302 HUMAN|HGNC=8373|UniProtKB=O76099 O76099 OR7C1 PTHR48001:SF195 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 7C1 transmembrane signal receptor#PC00197 HUMAN|HGNC=12940|UniProtKB=Q12901 Q12901 ZNF155 PTHR24377:SF430 IP01015P-RELATED ZINC FINGER PROTEIN 155 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=11086|UniProtKB=O94813 O94813 SLIT2 PTHR45836:SF2 SLIT HOMOLOG SLIT HOMOLOG 2 PROTEIN protein binding#GO:0005515;heparin binding#GO:0008201;binding#GO:0005488;signaling receptor binding#GO:0005102;glycosaminoglycan binding#GO:0005539;carbohydrate derivative binding#GO:0097367 axon guidance#GO:0007411;axon development#GO:0061564;plasma membrane bounded cell projection organization#GO:0120036;negative regulation of cell growth#GO:0030308;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;neurogenesis#GO:0022008;response to external stimulus#GO:0009605;neuron projection guidance#GO:0097485;cellular developmental process#GO:0048869;regulation of growth#GO:0040008;locomotion#GO:0040011;regulation of cellular process#GO:0050794;chemotaxis#GO:0006935;system development#GO:0048731;anatomical structure development#GO:0048856;cellular process#GO:0009987;neuron projection development#GO:0031175;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;taxis#GO:0042330;regulation of cell growth#GO:0001558;response to chemical#GO:0042221;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;cell projection morphogenesis#GO:0048858;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;cell development#GO:0048468;cell morphogenesis#GO:0000902;cell differentiation#GO:0030154;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;cell projection organization#GO:0030030;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;axonogenesis#GO:0007409;neuron development#GO:0048666 Axon guidance mediated by Slit/Robo#P00008>Slit#P00342 HUMAN|HGNC=30291|UniProtKB=Q9UN86 Q9UN86 G3BP2 PTHR10693:SF10 RAS GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN RAS GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN 2 mRNA binding#GO:0003729;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723;molecular condensate scaffold activity#GO:0140693 cellular process#GO:0009987;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cytoplasmic stress granule assembly#GO:0034063;cellular component assembly#GO:0022607;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840 organelle#GO:0043226;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;cytosol#GO:0005829;membraneless organelle#GO:0043228;cytoplasmic stress granule#GO:0010494;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031 HUMAN|HGNC=30797|UniProtKB=Q92544 Q92544 TM9SF4 PTHR10766:SF188 TRANSMEMBRANE 9 SUPERFAMILY PROTEIN TRANSMEMBRANE 9 SUPERFAMILY MEMBER 4 macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657;cellular process#GO:0009987;localization within membrane#GO:0051668;cellular localization#GO:0051641;localization#GO:0051179;intracellular protein localization#GO:0008104 membrane#GO:0016020;cellular anatomical structure#GO:0110165 transporter#PC00227 HUMAN|HGNC=23305|UniProtKB=Q8WV37 Q8WV37 ZNF480 PTHR24377:SF187 IP01015P-RELATED ZINC FINGER PROTEIN 480 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677 regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=12034|UniProtKB=Q9BUZ4 Q9BUZ4 TRAF4 PTHR10131:SF164 TNF RECEPTOR ASSOCIATED FACTOR TNF RECEPTOR-ASSOCIATED FACTOR 4 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;signaling adaptor activity#GO:0035591 cellular process#GO:0009987;regulation of canonical NF-kappaB signal transduction#GO:0043122;signal transduction#GO:0007165;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;cell surface receptor signaling pathway#GO:0007166;regulation of response to stimulus#GO:0048583;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cell communication#GO:0010646;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;cell communication#GO:0007154 scaffold/adaptor protein#PC00226 HUMAN|HGNC=6374|UniProtKB=P26715 P26715 KLRC1 PTHR22800:SF258 C-TYPE LECTIN PROTEINS NKG2-A_NKG2-B TYPE II INTEGRAL MEMBRANE PROTEIN transmembrane signaling receptor activity#GO:0004888;immune receptor activity#GO:0140375;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 immune response#GO:0006955;positive regulation of cellular process#GO:0048522;negative regulation of immune system process#GO:0002683;immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007;positive regulation of immune effector process#GO:0002699;positive regulation of response to stimulus#GO:0048584;regulation of natural killer cell mediated cytotoxicity#GO:0042269;negative regulation of response to stimulus#GO:0048585;positive regulation of immune response#GO:0050778;positive regulation of defense response#GO:0031349;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;positive regulation of response to biotic stimulus#GO:0002833;defense response#GO:0006952;regulation of innate immune response#GO:0045088;innate immune response#GO:0045087;regulation of natural killer cell mediated immunity#GO:0002715;cellular response to stimulus#GO:0051716;innate immune response-activating signaling pathway#GO:0002758;positive regulation of natural killer cell mediated immunity#GO:0002717;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of immune response#GO:0050776;negative regulation of immune response#GO:0050777;regulation of defense response#GO:0031347;positive regulation of lymphocyte mediated immunity#GO:0002708;regulation of immune effector process#GO:0002697;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;signal transduction#GO:0007165;defense response to symbiont#GO:0140546;cellular process#GO:0009987;response to biotic stimulus#GO:0009607;positive regulation of immune system process#GO:0002684;regulation of response to external stimulus#GO:0032101;defense response to other organism#GO:0098542;immune response-activating signaling pathway#GO:0002757;regulation of biological process#GO:0050789;immune response-regulating signaling pathway#GO:0002764;negative regulation of biological process#GO:0048519;response to stimulus#GO:0050896;regulation of cell killing#GO:0031341;regulation of lymphocyte mediated immunity#GO:0002706;immune system process#GO:0002376;lymphocyte mediated immunity#GO:0002449;positive regulation of innate immune response#GO:0045089;activation of innate immune response#GO:0002218;positive regulation of natural killer cell mediated cytotoxicity#GO:0045954;response to other organism#GO:0051707;positive regulation of leukocyte mediated immunity#GO:0002705;regulation of response to stress#GO:0080134;response to external stimulus#GO:0009605;regulation of leukocyte mediated immunity#GO:0002703;response to external biotic stimulus#GO:0043207;immune response-activating cell surface receptor signaling pathway#GO:0002429;regulation of response to biotic stimulus#GO:0002831;negative regulation of defense response#GO:0031348;regulation of leukocyte mediated cytotoxicity#GO:0001910;cell communication#GO:0007154;response to stress#GO:0006950;negative regulation of response to external stimulus#GO:0032102;negative regulation of innate immune response#GO:0045824;cell surface receptor signaling pathway#GO:0007166;immune effector process#GO:0002252;positive regulation of response to external stimulus#GO:0032103;natural killer cell mediated immunity#GO:0002228;biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052;leukocyte mediated immunity#GO:0002443 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cell surface#GO:0009986;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090 HUMAN|HGNC=21055|UniProtKB=Q6UB35 Q6UB35 MTHFD1L PTHR48099:SF12 C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED MONOFUNCTIONAL C1-TETRAHYDROFOLATE SYNTHASE, MITOCHONDRIAL hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;ligase activity, forming carbon-nitrogen bonds#GO:0016879;hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;ligase activity#GO:0016874;catalytic activity#GO:0003824 tetrahydrofolate metabolic process#GO:0046653;tetrahydrofolate biosynthetic process#GO:0046654;small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;biosynthetic process#GO:0009058;small molecule metabolic process#GO:0044281;pteridine-containing compound metabolic process#GO:0042558;folic acid-containing compound metabolic process#GO:0006760;cellular process#GO:0009987;carboxylic acid biosynthetic process#GO:0046394;carboxylic acid metabolic process#GO:0019752;modified amino acid metabolic process#GO:0006575 mitochondrion#GO:0005739;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 metabolite interconversion enzyme#PC00262 Formyltetrahydrofolate biosynthesis#P02743>Methylene tetrahydrofolate dehydrogenase#P02952 HUMAN|HGNC=9903|UniProtKB=P78332 P78332 RBM6 PTHR13948:SF22 RNA-BINDING PROTEIN RNA-BINDING PROTEIN 6 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;mRNA splicing, via spliceosome#GO:0000398;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=26145|UniProtKB=Q9H6V9 Q9H6V9 LDAH PTHR13390:SF4 LIPASE LIPID DROPLET-ASSOCIATED HYDROLASE catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787 cholesterol homeostasis#GO:0042632;cellular component organization or biogenesis#GO:0071840;chemical homeostasis#GO:0048878;lipid droplet organization#GO:0034389;homeostatic process#GO:0042592;cellular process#GO:0009987;cellular component organization#GO:0016043;lipid homeostasis#GO:0055088;organelle organization#GO:0006996 intracellular anatomical structure#GO:0005622;lipid droplet#GO:0005811;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229 lipase#PC00143;hydrolase#PC00121 HUMAN|HGNC=11580|UniProtKB=Q15814 Q15814 TBCC PTHR15139:SF0 TUBULIN FOLDING COFACTOR C TUBULIN-SPECIFIC CHAPERONE C microtubule-based process#GO:0007017;protein-containing complex organization#GO:0043933;microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 chaperone#PC00072 HUMAN|HGNC=14464|UniProtKB=Q96T55 Q96T55 KCNK16 PTHR11003:SF104 POTASSIUM CHANNEL, SUBFAMILY K POTASSIUM CHANNEL SUBFAMILY K MEMBER 16 monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;transporter activity#GO:0005215;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated monoatomic ion channel activity#GO:0005244;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;monoatomic cation channel activity#GO:0005261;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;potassium channel activity#GO:0005267;outward rectifier potassium channel activity#GO:0015271 transport#GO:0006810;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;potassium ion transmembrane transport#GO:0071805;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HUMAN|HGNC=1507|UniProtKB=P55212 P55212 CASP6 PTHR10454:SF206 CASPASE CASPASE-6 peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;cysteine-type endopeptidase activity#GO:0004197;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824 regulation of apoptotic process#GO:0042981;positive regulation of neuron apoptotic process#GO:0043525;positive regulation of apoptotic process#GO:0043065;positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789;positive regulation of cellular process#GO:0048522;cell death#GO:0008219;apoptotic process#GO:0006915;cellular process#GO:0009987;regulation of programmed cell death#GO:0043067;regulation of neuron apoptotic process#GO:0043523;programmed cell death#GO:0012501;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;positive regulation of programmed cell death#GO:0043068 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protease#PC00190;protein modifying enzyme#PC00260 FAS signaling pathway#P00020>Caspase6#P00596;Huntington disease#P00029>Caspase 6#P00809;FAS signaling pathway#P00020>Pro-Caspase6#P00607 HUMAN|HGNC=21099|UniProtKB=Q5T9G4 Q5T9G4 ARMC12 PTHR47144:SF1 ARMADILLO REPEAT-CONTAINING PROTEIN 12 ARMADILLO REPEAT-CONTAINING PROTEIN 12 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=28086|UniProtKB=Q8N183 Q8N183 NDUFAF2 PTHR32470:SF2 ADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2 NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2 protein-containing complex organization#GO:0043933;NADH dehydrogenase complex assembly#GO:0010257;cellular component organization or biogenesis#GO:0071840;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;mitochondrial respiratory chain complex I assembly#GO:0032981;cellular component organization#GO:0016043;mitochondrial respiratory chain complex assembly#GO:0033108;mitochondrion organization#GO:0007005;cellular component assembly#GO:0022607 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739 chaperone#PC00072 HUMAN|HGNC=6878|UniProtKB=P31152 P31152 MAPK4 PTHR24055:SF25 MITOGEN-ACTIVATED PROTEIN KINASE MITOGEN-ACTIVATED PROTEIN KINASE 4 phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cell surface receptor signaling pathway#GO:0007166 nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 Alzheimer disease-amyloid secretase pathway#P00003>MAPK#P00099 HUMAN|HGNC=24787|UniProtKB=Q6ZSS3 Q6ZSS3 ZNF621 PTHR23226:SF441 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER PROTEIN 621 cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=15132|UniProtKB=Q8NH74 Q8NH74 OR10A6 PTHR26453:SF692 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 10A6 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 system process#GO:0003008;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;nervous system process#GO:0050877;sensory perception#GO:0007600;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;response to chemical#GO:0042221;response to stimulus#GO:0050896;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;detection of chemical stimulus#GO:0009593 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=18860|UniProtKB=Q9NR71 Q9NR71 ASAH2 PTHR12670:SF21 CERAMIDASE NEUTRAL CERAMIDASE hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;catalytic activity#GO:0003824;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811 sphingoid biosynthetic process#GO:0046520;ceramide metabolic process#GO:0006672;oxoacid metabolic process#GO:0043436;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;carboxylic acid biosynthetic process#GO:0046394;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;sphingolipid catabolic process#GO:0030149;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid biosynthetic process#GO:0072330;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;alcohol metabolic process#GO:0006066;sphingolipid biosynthetic process#GO:0030148;fatty acid metabolic process#GO:0006631;fatty acid biosynthetic process#GO:0006633;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;lipid catabolic process#GO:0016042;alcohol biosynthetic process#GO:0046165;cellular process#GO:0009987;long-chain fatty acid metabolic process#GO:0001676 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 HUMAN|HGNC=52398|UniProtKB=A0A1B0GTS1 A0A1B0GTS1 HSFX4 PTHR10015:SF140 HEAT SHOCK TRANSCRIPTION FACTOR HEAT SHOCK TRANSCRIPTION FACTOR, X-LINKED MEMBER 3-RELATED helix-turn-helix transcription factor#PC00116;gene-specific transcriptional regulator#PC00264;winged helix/forkhead transcription factor#PC00246 HUMAN|HGNC=2215|UniProtKB=P27658 P27658 COL8A1 PTHR24023:SF903 COLLAGEN ALPHA COLLAGEN ALPHA-1(VIII) CHAIN extracellular matrix structural constituent#GO:0005201;structural molecule activity#GO:0005198 extracellular structure organization#GO:0043062;cellular component organization#GO:0016043;cellular process#GO:0009987;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;external encapsulating structure organization#GO:0045229 cellular anatomical structure#GO:0110165;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 Integrin signalling pathway#P00034>Collagen#P00922 HUMAN|HGNC=19829|UniProtKB=Q8N128 Q8N128 FAM177A1 PTHR31206:SF5 LP10445P PROTEIN FAM177A1 HUMAN|HGNC=9099|UniProtKB=Q9UIW2 Q9UIW2 PLXNA1 PTHR22625:SF35 PLEXIN PLEXIN-A1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 developmental process#GO:0032502;cellular developmental process#GO:0048869;negative regulation of cell adhesion#GO:0007162;plasma membrane bounded cell projection organization#GO:0120036;cell communication#GO:0007154;regulation of cell motility#GO:2000145;regulation of nervous system development#GO:0051960;system development#GO:0048731;regulation of developmental process#GO:0050793;positive regulation of neurogenesis#GO:0050769;cell surface receptor signaling pathway#GO:0007166;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell projection morphogenesis#GO:0048858;regulation of axonogenesis#GO:0050770;cellular component assembly#GO:0022607;regulation of multicellular organismal process#GO:0051239;positive regulation of cellular component organization#GO:0051130;generation of neurons#GO:0048699;positive regulation of axonogenesis#GO:0050772;cellular component organization#GO:0016043;regulation of multicellular organismal development#GO:2000026;positive regulation of nervous system development#GO:0051962;cell differentiation#GO:0030154;cell projection organization#GO:0030030;signaling#GO:0023052;regulation of cell projection organization#GO:0031344;negative regulation of cellular process#GO:0048523;positive regulation of developmental process#GO:0051094;regulation of cell migration#GO:0030334;regulation of cell differentiation#GO:0045595;neuron projection morphogenesis#GO:0048812;regulation of plasma membrane bounded cell projection organization#GO:0120035;neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;positive regulation of cellular process#GO:0048522;regulation of cell development#GO:0060284;regulation of cell adhesion#GO:0030155;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;synapse organization#GO:0050808;positive regulation of cell projection organization#GO:0031346;anatomical structure development#GO:0048856;regulation of neurogenesis#GO:0050767;cellular response to stimulus#GO:0051716;cell junction organization#GO:0034330;regulation of cellular process#GO:0050794;neuron differentiation#GO:0030182;positive regulation of cell differentiation#GO:0045597;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;regulation of anatomical structure morphogenesis#GO:0022603;cellular component biogenesis#GO:0044085;neuron projection development#GO:0031175;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;regulation of neuron projection development#GO:0010975;cellular process#GO:0009987;positive regulation of cell development#GO:0010720;nervous system development#GO:0007399;animal gross anatomical part developmental process#GO:0160108;regulation of biological quality#GO:0065008;neuron development#GO:0048666;cell junction assembly#GO:0034329;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;regulation of cell shape#GO:0008360;positive regulation of multicellular organismal process#GO:0051240;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;cell morphogenesis#GO:0000902;synapse assembly#GO:0007416;cell development#GO:0048468 plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;signaling receptor complex#GO:0043235;membrane#GO:0016020 transmembrane signal receptor#PC00197 Axon guidance mediated by semaphorins#P00007>PlexinA1#P00334 HUMAN|HGNC=934|UniProtKB=Q9Y5Z0 Q9Y5Z0 BACE2 PTHR47965:SF40 ASPARTYL PROTEASE-RELATED BETA-SECRETASE 2 catalytic activity#GO:0003824;aspartic-type endopeptidase activity#GO:0004190;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;proteolysis#GO:0006508;membrane protein ectodomain proteolysis#GO:0006509;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;membrane protein proteolysis#GO:0033619;protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;cell periphery#GO:0071944;endomembrane system#GO:0012505;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;plasma membrane#GO:0005886;Golgi apparatus#GO:0005794;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227 protease#PC00190 Alzheimer disease-presenilin pathway#P00004>Pro-BACE-1#P00162;Alzheimer disease-amyloid secretase pathway#P00003>Pro-BACE-1#P00081;Alzheimer disease-presenilin pathway#P00004>BACE-1 pro-domain#P00178;Alzheimer disease-amyloid secretase pathway#P00003>BACE-1 pro-domain#P00094;Alzheimer disease-presenilin pathway#P00004>BACE-1#P00172;Alzheimer disease-amyloid secretase pathway#P00003>BACE-1#P00101 HUMAN|HGNC=6858|UniProtKB=O95382 O95382 MAP3K6 PTHR11584:SF391 SERINE/THREONINE PROTEIN KINASE MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 6 transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;MAP kinase kinase kinase activity#GO:0004709;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signaling#GO:0023052;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124;p38MAPK cascade#GO:0038066;response to stimulus#GO:0050896;JNK cascade#GO:0007254;regulation of cellular process#GO:0050794;intracellular signal transduction#GO:0035556;MAPK cascade#GO:0000165;cell communication#GO:0007154 non-receptor serine/threonine protein kinase#PC00167 FGF signaling pathway#P00021>MEKK1-5#P00634 HUMAN|HGNC=4568|UniProtKB=Q13905 Q13905 RAPGEF1 PTHR23113:SF224 GUANINE NUCLEOTIDE EXCHANGE FACTOR RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1 guanyl-nucleotide exchange factor activity#GO:0005085;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 positive regulation of neuron projection development#GO:0010976;Ras protein signal transduction#GO:0007265;positive regulation of cellular component organization#GO:0051130;positive regulation of cell projection organization#GO:0031346;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of cell projection organization#GO:0031344;regulation of plasma membrane bounded cell projection organization#GO:0120035;positive regulation of biological process#GO:0048518;regulation of neuron projection development#GO:0010975;signal transduction#GO:0007165;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;intracellular signaling cassette#GO:0141124 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 guanyl-nucleotide exchange factor#PC00113 Integrin signalling pathway#P00034>C3G#P00929 HUMAN|HGNC=9753|UniProtKB=Q16769 Q16769 QPCT PTHR12283:SF5 GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE zinc ion binding#GO:0008270;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;transition metal ion binding#GO:0046914;metal ion binding#GO:0046872;cation binding#GO:0043169 transferase#PC00220 HUMAN|HGNC=42975|UniProtKB=Q96EF9 Q96EF9 ZHX1-C8orf76 PTHR31919:SF1 ZINC FINGERS AND HOMEOBOXES PROTEIN 1, ISOFORM 2 ZINC FINGERS AND HOMEOBOXES PROTEIN 1, ISOFORM 2 homeodomain transcription factor#PC00119 HUMAN|HGNC=24679|UniProtKB=Q96IG2 Q96IG2 FBXL20 PTHR13318:SF47 PARTNER OF PAIRED, ISOFORM B-RELATED F-BOX_LRR-REPEAT PROTEIN 20 cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;intracellular protein-containing complex#GO:0140535;SCF ubiquitin ligase complex#GO:0019005;cullin-RING ubiquitin ligase complex#GO:0031461;transferase complex#GO:1990234;catalytic complex#GO:1902494 HUMAN|HGNC=17652|UniProtKB=Q9H237 Q9H237 PORCN PTHR13906:SF12 PORCUPINE PROTEIN-SERINE O-PALMITOLEOYLTRANSFERASE PORCUPINE protein binding#GO:0005515;Wnt-protein binding#GO:0017147;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;binding#GO:0005488;transferase activity#GO:0016740 establishment of protein localization#GO:0045184;cellular process#GO:0009987;macromolecule localization#GO:0033036;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;transport#GO:0006810;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;intracellular protein localization#GO:0008104;establishment of protein localization to extracellular region#GO:0035592;lipid modification#GO:0030258;establishment of localization#GO:0051234;regulation of biological process#GO:0050789;protein localization to extracellular region#GO:0071692;primary metabolic process#GO:0044238;export from cell#GO:0140352;signaling#GO:0023052;signal release#GO:0023061;secretion by cell#GO:0032940;protein transport#GO:0015031;protein secretion#GO:0009306;localization#GO:0051179;cell communication#GO:0007154;secretion#GO:0046903 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 acetyltransferase#PC00038 HUMAN|HGNC=20532|UniProtKB=P60329 P60329 KRTAP12-4 PTHR23262:SF180 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 12-1-RELATED structural protein#PC00211 HUMAN|HGNC=21060|UniProtKB=Q8TAA5 Q8TAA5 GRPEL2 PTHR21237:SF10 GRPE PROTEIN GRPE PROTEIN HOMOLOG 2, MITOCHONDRIAL enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function regulator activity#GO:0098772 mitochondrial transmembrane transport#GO:1990542;localization#GO:0051179;cellular localization#GO:0051641;transmembrane transport#GO:0055085;protein transport#GO:0015031;protein localization to mitochondrion#GO:0070585;mitochondrial transport#GO:0006839;protein localization to organelle#GO:0033365;intracellular transport#GO:0046907;protein transmembrane import into intracellular organelle#GO:0044743;transport#GO:0006810;protein transmembrane transport#GO:0071806;intracellular protein transport#GO:0006886;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;intracellular protein transmembrane transport#GO:0065002;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;mitochondrial protein import pathway#GO:7770058;protein import into mitochondrial matrix#GO:0030150 inner mitochondrial membrane protein complex#GO:0098800;organelle membrane#GO:0031090;TIM23 mitochondrial import inner membrane translocase complex#GO:0005744;mitochondrial membrane#GO:0031966;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;membrane protein complex#GO:0098796;organelle envelope#GO:0031967;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 primary active transporter#PC00068;transporter#PC00227 HUMAN|HGNC=7871|UniProtKB=Q15233 Q15233 NONO PTHR23189:SF15 RNA RECOGNITION MOTIF-CONTAINING NON-POU DOMAIN-CONTAINING OCTAMER-BINDING PROTEIN RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 RNA metabolism protein#PC00031 HUMAN|HGNC=32466|UniProtKB=P0CB33 P0CB33 ZNF735 PTHR24384:SF228 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED ZINC FINGER PROTEIN 479-RELATED sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218 HUMAN|HGNC=13519|UniProtKB=Q9H1K6 Q9H1K6 TLNRD1 PTHR47133:SF1 TALIN ROD DOMAIN-CONTAINING PROTEIN 1 TALIN ROD DOMAIN-CONTAINING PROTEIN 1 protein binding#GO:0005515;binding#GO:0005488;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092 HUMAN|HGNC=30325|UniProtKB=Q9H477 Q9H477 RBKS PTHR10584:SF166 SUGAR KINASE RIBOKINASE phosphotransferase activity, alcohol group as acceptor#GO:0016773;carbohydrate kinase activity#GO:0019200;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 kinase#PC00137;carbohydrate kinase#PC00065 HUMAN|HGNC=37471|UniProtKB=P0CW00 P0CW00 TSPY8 PTHR11875:SF12 TESTIS-SPECIFIC Y-ENCODED PROTEIN TESTIS-SPECIFIC Y-ENCODED PROTEIN 1-RELATED histone binding#GO:0042393;chromatin binding#GO:0003682;binding#GO:0005488;protein binding#GO:0005515 chromosome#GO:0005694;chromatin#GO:0000785;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=6148|UniProtKB=P20701 P20701 ITGAL PTHR23220:SF84 INTEGRIN ALPHA INTEGRIN ALPHA-L molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 integrin-mediated signaling pathway#GO:0007229;cell-cell adhesion#GO:0098609;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cell surface receptor signaling pathway#GO:0007166;cell adhesion#GO:0007155;cell-matrix adhesion#GO:0007160;cell communication#GO:0007154;cell-substrate adhesion#GO:0031589 signaling receptor complex#GO:0043235;integrin complex#GO:0008305;protein complex involved in cell adhesion#GO:0098636;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane#GO:0005886;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 integrin#PC00126;cell adhesion molecule#PC00069 Integrin signalling pathway#P00034>Integrin alpha#P00941;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Integrin#P00853 HUMAN|HGNC=9506|UniProtKB=O60759 O60759 CYTIP PTHR15963:SF1 GENERAL RECEPTOR FOR PHOSPHOINOSITIDES 1-ASSOCIATED SCAFFOLD PROTEIN-RELATED CYTOHESIN-INTERACTING PROTEIN biological regulation#GO:0065007;regulation of cell adhesion#GO:0030155;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;cell cortex#GO:0005938;cytosol#GO:0005829 HUMAN|HGNC=1514|UniProtKB=P41180 P41180 CASR PTHR24061:SF358 CALCIUM-SENSING RECEPTOR-RELATED EXTRACELLULAR CALCIUM-SENSING RECEPTOR signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;cation binding#GO:0043169;metal ion binding#GO:0046872;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;calcium ion binding#GO:0005509;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167 cellular homeostasis#GO:0019725;regulation of localization#GO:0032879;regulation of transport#GO:0051049;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;intracellular monoatomic cation homeostasis#GO:0030003;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;response to metal ion#GO:0010038;regulation of calcium ion transport#GO:0051924;biological regulation#GO:0065007;response to chemical#GO:0042221;regulation of monoatomic ion transport#GO:0043269;monoatomic ion homeostasis#GO:0050801;detection of stimulus#GO:0051606;response to calcium ion#GO:0051592;inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;homeostatic process#GO:0042592;response to stimulus#GO:0050896;regulation of metal ion transport#GO:0010959;detection of chemical stimulus#GO:0009593;regulation of biological process#GO:0050789;intracellular monoatomic ion homeostasis#GO:0006873 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=34437|UniProtKB=Q5BLP8 Q5BLP8 NICOL1 PTHR35451:SF1 NEUROPEPTIDE-LIKE PROTEIN C4ORF48 NELL2-INTERACTING CELL ONTOGENY REGULATOR 1 reproductive process#GO:0022414;gamete generation#GO:0007276;male gamete generation#GO:0048232;developmental process involved in reproduction#GO:0003006;multicellular organismal reproductive process#GO:0048609;spermatogenesis#GO:0007283;sexual reproduction#GO:0019953;developmental process#GO:0032502 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=18137|UniProtKB=Q7LFX5 Q7LFX5 CHST15 PTHR15723:SF0 CARBOHYDRATE SULFOTRANSFERASE 15 CARBOHYDRATE SULFOTRANSFERASE 15 transferase activity, transferring sulphur-containing groups#GO:0016782;sulfotransferase activity#GO:0008146;transferase activity#GO:0016740;catalytic activity#GO:0003824 monosaccharide metabolic process#GO:0005996;metabolic process#GO:0008152;small molecule biosynthetic process#GO:0044283;hexose metabolic process#GO:0019318;primary metabolic process#GO:0044238;cellular process#GO:0009987;hexose biosynthetic process#GO:0019319;small molecule metabolic process#GO:0044281;carbohydrate biosynthetic process#GO:0016051;carbohydrate metabolic process#GO:0005975;biosynthetic process#GO:0009058;monosaccharide biosynthetic process#GO:0046364 transferase#PC00220;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=15205|UniProtKB=Q8NGJ9 Q8NGJ9 OR51T1 PTHR26450:SF6 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 51T1 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=6055|UniProtKB=Q17R60 Q17R60 IMPG1 PTHR12199:SF3 INTERPHOTORECEPTOR MATRIX PROTEOGLYCAN INTERPHOTORECEPTOR MATRIX PROTEOGLYCAN 1 extracellular matrix protein#PC00102 HUMAN|HGNC=15287|UniProtKB=P0C626 P0C626 OR5G3 PTHR26452:SF292 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5G3 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 nervous system process#GO:0050877;sensory perception#GO:0007600;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=16792|UniProtKB=Q92540 Q92540 SMG7 PTHR15696:SF5 SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7 NONSENSE-MEDIATED MRNA DECAY FACTOR SMG7 nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;telomeric repeat DNA binding#GO:0042162 RNA catabolic process#GO:0006401;RNA metabolic process#GO:0016070;regulation of biological process#GO:0050789;primary metabolic process#GO:0044238;negative regulation of gene expression#GO:0010629;nucleic acid metabolic process#GO:0090304;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay#GO:0000184;macromolecule catabolic process#GO:0009057;negative regulation of cellular process#GO:0048523;metabolic process#GO:0008152;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;nucleic acid catabolic process#GO:0141188;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleobase-containing compound catabolic process#GO:0034655;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ribonucleoprotein complex#GO:1990904;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634 RNA metabolism protein#PC00031 HUMAN|HGNC=28801|UniProtKB=Q9H3H3 Q9H3H3 C11orf68 PTHR31977:SF1 UPF0696 PROTEIN C11ORF68 UPF0696 PROTEIN C11ORF68 HUMAN|HGNC=8091|UniProtKB=P04181 P04181 OAT PTHR11986:SF118 AMINOTRANSFERASE CLASS III ORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL transferase activity#GO:0016740;catalytic activity#GO:0003824;transaminase activity#GO:0008483 oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;arginine metabolic process#GO:0006525;amino acid metabolic process#GO:0006520;small molecule catabolic process#GO:0044282;proteinogenic amino acid metabolic process#GO:0170039;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 transaminase#PC00216 HUMAN|HGNC=14287|UniProtKB=Q8N0W4 Q8N0W4 NLGN4X PTHR43903:SF25 NEUROLIGIN NEUROLIGIN-4, X-LINKED cellular anatomical structure#GO:0110165;synapse#GO:0045202;postsynaptic specialization#GO:0099572;organelle#GO:0043226;plasma membrane region#GO:0098590;plasma membrane#GO:0005886;postsynapse#GO:0098794;membrane#GO:0016020;cell periphery#GO:0071944;cell junction#GO:0030054;postsynaptic specialization membrane#GO:0099634;postsynaptic membrane#GO:0045211;synaptic membrane#GO:0097060 cell adhesion molecule#PC00069 HUMAN|HGNC=18651|UniProtKB=Q7Z7M1 Q7Z7M1 ADGRD2 PTHR12011:SF58 ADHESION G-PROTEIN COUPLED RECEPTOR ADHESION G PROTEIN-COUPLED RECEPTOR D2 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=8933|UniProtKB=Q8WV24 Q8WV24 PHLDA1 PTHR15478:SF4 PLECKSTRIN HOMOLOGY-LIKE DOMAIN, PQ-RICH PROTEIN PLECKSTRIN HOMOLOGY-LIKE DOMAIN FAMILY A MEMBER 1 regulation of apoptotic process#GO:0042981;positive regulation of apoptotic process#GO:0043065;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;positive regulation of biological process#GO:0048518;regulation of programmed cell death#GO:0043067;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;positive regulation of programmed cell death#GO:0043068 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=9463|UniProtKB=P21108 P21108 PRPS1L1 PTHR10210:SF112 RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 3 transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740 nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;nucleotide biosynthetic process#GO:0009165;organophosphate biosynthetic process#GO:0090407;nucleotide metabolic process#GO:0009117;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;ribose phosphate biosynthetic process#GO:0046390;organophosphate metabolic process#GO:0019637;nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative biosynthetic process#GO:1901137;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 catalytic complex#GO:1902494;transferase complex#GO:1990234;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 nucleotide kinase#PC00172;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=9951|UniProtKB=P05451 P05451 REG1A PTHR22803:SF131 MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED LITHOSTATHINE-1-ALPHA hormone activity#GO:0005179;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;growth factor activity#GO:0008083;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545 antimicrobial humoral response#GO:0019730;humoral immune response#GO:0006959;defense response#GO:0006952;response to external stimulus#GO:0009605;response to hormone#GO:0009725;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;positive regulation of biological process#GO:0048518;defense response to symbiont#GO:0140546;positive regulation of cellular process#GO:0048522;immune response#GO:0006955;defense response to other organism#GO:0098542;response to chemical#GO:0042221;response to peptide hormone#GO:0043434;response to other organism#GO:0051707;biological regulation#GO:0065007;immune system process#GO:0002376;response to oxygen-containing compound#GO:1901700;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;regulation of cell population proliferation#GO:0042127;response to nitrogen compound#GO:1901698;positive regulation of cell population proliferation#GO:0008284;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 membrane trafficking regulatory protein#PC00151 CCKR signaling map#P06959>REG1A#G07269;CCKR signaling map#P06959>REG1A#G06976 HUMAN|HGNC=10611|UniProtKB=Q99616 Q99616 CCL13 PTHR12015:SF147 SMALL INDUCIBLE CYTOKINE A C-C MOTIF CHEMOKINE 13 protein binding#GO:0005515;chemokine receptor binding#GO:0042379;molecular function activator activity#GO:0140677;binding#GO:0005488;cytokine receptor binding#GO:0005126;signaling receptor binding#GO:0005102;cytokine activity#GO:0005125;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;chemokine activity#GO:0008009;G protein-coupled receptor binding#GO:0001664 regulation of cell migration#GO:0030334;leukocyte migration#GO:0050900;positive regulation of locomotion#GO:0040017;response to external stimulus#GO:0009605;myeloid leukocyte migration#GO:0097529;defense response#GO:0006952;leukocyte chemotaxis#GO:0030595;immune response#GO:0006955;positive regulation of cellular process#GO:0048522;positive regulation of cell migration#GO:0030335;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;response to other organism#GO:0051707;cell migration#GO:0016477;inflammatory response#GO:0006954;chemotaxis#GO:0006935;cytokine-mediated signaling pathway#GO:0019221;cell chemotaxis#GO:0060326;regulation of cell motility#GO:2000145;chemokine-mediated signaling pathway#GO:0070098;cell communication#GO:0007154;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;cellular response to stimulus#GO:0051716;response to external biotic stimulus#GO:0043207;locomotion#GO:0040011;cellular response to chemokine#GO:1990869;cell motility#GO:0048870;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;antimicrobial humoral response#GO:0019730;humoral immune response#GO:0006959;defense response to symbiont#GO:0140546;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;response to biotic stimulus#GO:0009607;response to chemokine#GO:1990868;response to stress#GO:0006950;response to chemical#GO:0042221;taxis#GO:0042330;response to cytokine#GO:0034097;defense response to other organism#GO:0098542;granulocyte migration#GO:0097530;G protein-coupled receptor signaling pathway#GO:0007186;immune system process#GO:0002376;cellular response to chemical stimulus#GO:0070887;response to peptide#GO:1901652;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;positive regulation of cell motility#GO:2000147;biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052;response to stimulus#GO:0050896;granulocyte chemotaxis#GO:0071621 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 cytokine#PC00083 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CHK#P00856 HUMAN|HGNC=26926|UniProtKB=Q8N5M9 Q8N5M9 JAGN1 PTHR20955:SF4 PROTEIN JAGUNAL HOMOLOG 1 PROTEIN JAGUNAL HOMOLOG 1 cytokine-mediated signaling pathway#GO:0019221;localization#GO:0051179;cell communication#GO:0007154;response to peptide#GO:1901652;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;endoplasmic reticulum organization#GO:0007029;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;transport#GO:0006810;cell surface receptor signaling pathway#GO:0007166;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;organelle organization#GO:0006996;signal transduction#GO:0007165;cellular process#GO:0009987;response to chemical#GO:0042221;response to cytokine#GO:0034097;vesicle-mediated transport#GO:0016192;biological regulation#GO:0065007;endomembrane system organization#GO:0010256 membrane#GO:0016020;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984 HUMAN|HGNC=33736|UniProtKB=A5PLL1 A5PLL1 ANKRD34B PTHR24156:SF1 ANK_REP_REGION DOMAIN-CONTAINING PROTEIN ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 34B HUMAN|HGNC=17056|UniProtKB=Q9Y2J0 Q9Y2J0 RPH3A PTHR45729:SF3 RABPHILIN, ISOFORM A RABPHILIN-3A vesicle-mediated transport#GO:0016192;neurotransmitter transport#GO:0006836;synaptic signaling#GO:0099536;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;positive regulation of secretion by cell#GO:1903532;positive regulation of transport#GO:0051050;synaptic vesicle exocytosis#GO:0016079;positive regulation of biological process#GO:0048518;vesicle-mediated transport in synapse#GO:0099003;exocytosis#GO:0006887;positive regulation of vesicle fusion#GO:0031340;regulation of localization#GO:0032879;regulation of transport#GO:0051049;regulated exocytosis#GO:0045055;regulation of cellular component organization#GO:0051128;signaling#GO:0023052;export from cell#GO:0140352;regulation of organelle organization#GO:0033043;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;cellular localization#GO:0051641;positive regulation of organelle organization#GO:0010638;regulation of secretion by cell#GO:1903530;secretion by cell#GO:0032940;positive regulation of cellular component organization#GO:0051130;positive regulation of secretion#GO:0051047;neurotransmitter secretion#GO:0007269;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;positive regulation of cellular process#GO:0048522;establishment of localization#GO:0051234;synaptic vesicle cycle#GO:0099504;transport#GO:0006810;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;signal release from synapse#GO:0099643;chemical synaptic transmission#GO:0007268;secretion#GO:0046903;regulation of secretion#GO:0051046;cell communication#GO:0007154;localization#GO:0051179;regulation of exocytosis#GO:0017157;trans-synaptic signaling#GO:0099537;signal release#GO:0023061 plasma membrane#GO:0005886;transport vesicle membrane#GO:0030658;endomembrane system#GO:0012505;plasma membrane region#GO:0098590;transport vesicle#GO:0030133;cell periphery#GO:0071944;membrane#GO:0016020;vesicle membrane#GO:0012506;organelle membrane#GO:0031090;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;synaptic vesicle#GO:0008021;vesicle#GO:0031982;synaptic vesicle membrane#GO:0030672;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;presynapse#GO:0098793;neuron projection#GO:0043005;secretory vesicle#GO:0099503;bounding membrane of organelle#GO:0098588;cell junction#GO:0030054;extrinsic component of membrane#GO:0019898;synaptic membrane#GO:0097060;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;postsynapse#GO:0098794;intracellular vesicle#GO:0097708;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;postsynaptic membrane#GO:0045211 HUMAN|HGNC=2358|UniProtKB=Q13324 Q13324 CRHR2 PTHR45620:SF19 PDF RECEPTOR-LIKE PROTEIN-RELATED CORTICOTROPIN-RELEASING HORMONE RECEPTOR 2 peptide hormone binding#GO:0017046;signaling receptor activity#GO:0038023;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;hormone binding#GO:0042562;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;binding#GO:0005488 positive regulation of signaling#GO:0023056;cell communication#GO:0007154;regulation of biological quality#GO:0065008;positive regulation of synaptic transmission#GO:0050806;G protein-coupled receptor signaling pathway#GO:0007186;regulation of signaling#GO:0023051;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;response to stimulus#GO:0050896;regulation of cell communication#GO:0010646;modulation of chemical synaptic transmission#GO:0050804;signaling#GO:0023052;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of synaptic plasticity#GO:0048167;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;regulation of trans-synaptic signaling#GO:0099177;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522 synapse#GO:0045202;cellular anatomical structure#GO:0110165;neuron projection terminus#GO:0044306;cell projection#GO:0042995;distal axon#GO:0150034;plasma membrane bounded cell projection#GO:0120025;dendrite#GO:0030425;axon#GO:0030424;dendritic tree#GO:0097447;membrane#GO:0016020;presynapse#GO:0098793;neuron projection#GO:0043005;cell periphery#GO:0071944;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;cell junction#GO:0030054;axon terminus#GO:0043679 transmembrane signal receptor#PC00197 Cortocotropin releasing factor receptor signaling pathway#P04380>CRHR1#P04451 HUMAN|HGNC=30581|UniProtKB=Q8TE77 Q8TE77 SSH3 PTHR45864:SF4 SLINGSHOT PROTEIN PHOSPHATASE HOMOLOG PROTEIN PHOSPHATASE SLINGSHOT HOMOLOG 3 catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;cytoskeletal protein binding#GO:0008092;phosphatase activity#GO:0016791;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;binding#GO:0005488;actin binding#GO:0003779;hydrolase activity#GO:0016787;protein binding#GO:0005515;phosphoprotein phosphatase activity#GO:0004721 regulation of anatomical structure size#GO:0090066;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;organelle organization#GO:0006996;regulation of actin cytoskeleton organization#GO:0032956;cytoskeleton organization#GO:0007010;regulation of actin filament length#GO:0030832;regulation of biological quality#GO:0065008;regulation of organelle organization#GO:0033043;regulation of cellular component size#GO:0032535;regulation of biological process#GO:0050789;regulation of protein-containing complex assembly#GO:0043254;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;regulation of cellular component biogenesis#GO:0044087;negative regulation of actin filament polymerization#GO:0030837;regulation of cellular component organization#GO:0051128;negative regulation of cellular process#GO:0048523;regulation of actin filament-based process#GO:0032970;regulation of actin filament organization#GO:0110053;biological regulation#GO:0065007;regulation of actin polymerization or depolymerization#GO:0008064;regulation of actin filament polymerization#GO:0030833;actin filament-based process#GO:0030029;negative regulation of protein polymerization#GO:0032272;negative regulation of protein-containing complex assembly#GO:0031333;negative regulation of cytoskeleton organization#GO:0051494;regulation of supramolecular fiber organization#GO:1902903;negative regulation of cellular component organization#GO:0051129;negative regulation of organelle organization#GO:0010639;regulation of cellular process#GO:0050794;actin cytoskeleton organization#GO:0030036;negative regulation of supramolecular fiber organization#GO:1902904;regulation of protein polymerization#GO:0032271;regulation of cytoskeleton organization#GO:0051493 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 protein phosphatase#PC00195 Cytoskeletal regulation by Rho GTPase#P00016>Slingshot#P00509 HUMAN|HGNC=7827|UniProtKB=Q9BPW8 Q9BPW8 NIPSNAP1 PTHR21017:SF11 NIPSNAP-RELATED PROTEIN NIPSNAP HOMOLOG 1 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 autophagy of mitochondrion#GO:0000422;metabolic process#GO:0008152;process utilizing autophagic mechanism#GO:0061919;mitophagy#GO:0000423;cellular process#GO:0009987;autophagy#GO:0006914;macroautophagy#GO:0016236;catabolic process#GO:0009056 mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=15923|UniProtKB=Q14498 Q14498 RBM39 PTHR48036:SF10 SPLICING FACTOR (PAD-1), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G15810)-RELATED RNA-BINDING PROTEIN 39 binding#GO:0005488;ribonucleoprotein complex binding#GO:0043021;protein-containing complex binding#GO:0044877 RNA splicing factor#PC00148;RNA metabolism protein#PC00031;RNA processing factor#PC00147 HUMAN|Gene=YB057_HUMAN|UniProtKB=A8MUA0 A8MUA0 PTHR15566:SF7 POM121-LIKE UPF0607 PROTEIN ENSP00000381514-RELATED HUMAN|HGNC=1570|UniProtKB=P32238 P32238 CCKAR PTHR24241:SF120 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR CHOLECYSTOKININ RECEPTOR TYPE A molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528 regulation of hormone levels#GO:0010817;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;regulation of cell communication#GO:0010646;signaling#GO:0023052;regulation of cellular process#GO:0050794;cellular response to hormone stimulus#GO:0032870;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;regulation of signaling#GO:0023051;G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887;regulation of biological quality#GO:0065008;regulation of secretion by cell#GO:1903530;cell communication#GO:0007154;regulation of secretion#GO:0051046;regulation of hormone secretion#GO:0046883;cellular process#GO:0009987;signal transduction#GO:0007165;response to hormone#GO:0009725;biological regulation#GO:0065007;response to chemical#GO:0042221;regulation of transport#GO:0051049;regulation of localization#GO:0032879 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=12662|UniProtKB=P61758 P61758 VBP1 PTHR12409:SF0 PREFOLDIN SUBUNIT 3 PREFOLDIN SUBUNIT 3 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 protein metabolic process#GO:0019538;protein folding#GO:0006457;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;metabolic process#GO:0008152;gene expression#GO:0010467;protein maturation#GO:0051604;cellular component assembly#GO:0022607;biosynthetic process#GO:0009058;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 chaperone#PC00072 HUMAN|HGNC=21711|UniProtKB=Q7Z570 Q7Z570 ZNF804A PTHR17614:SF13 ZINC FINGER-CONTAINING ZINC FINGER PROTEIN 804A intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=20174|UniProtKB=Q9NVM9 Q9NVM9 INTS13 PTHR12955:SF1 SARCOMA ANTIGEN NY-SAR-95-RELATED INTEGRATOR COMPLEX SUBUNIT 13 localization#GO:0051179;regulation of cell cycle#GO:0051726;biological regulation#GO:0065007;centrosome localization#GO:0051642;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of mitotic cell cycle#GO:0007346;cellular process#GO:0009987 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;integrator complex#GO:0032039 HUMAN|HGNC=9207|UniProtKB=Q9UFF9 Q9UFF9 CNOT8 PTHR10797:SF1 CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 8 catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity, acting on ester bonds#GO:0016788;3'-5' exonuclease activity#GO:0008408;catalytic activity, acting on RNA#GO:0140098;RNA nuclease activity#GO:0004540;exonuclease activity#GO:0004527;3'-5'-RNA exonuclease activity#GO:0000175;hydrolase activity#GO:0016787;nuclease activity#GO:0004518 positive regulation of macromolecule metabolic process#GO:0010604;RNA destabilization#GO:0050779;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;regulation of mRNA metabolic process#GO:1903311;macromolecule catabolic process#GO:0009057;mRNA destabilization#GO:0061157;positive regulation of mRNA metabolic process#GO:1903313;metabolic process#GO:0008152;regulation of mRNA stability#GO:0043488;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;negative regulation of gene expression#GO:0010629;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;RNA metabolic process#GO:0016070;positive regulation of metabolic process#GO:0009893;regulation of biological quality#GO:0065008;RNA catabolic process#GO:0006401;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;nucleobase-containing compound catabolic process#GO:0034655;regulation of primary metabolic process#GO:0080090;nucleic acid catabolic process#GO:0141188;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;nuclear-transcribed mRNA catabolic process#GO:0000956;positive regulation of catabolic process#GO:0009896;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;positive regulation of mRNA catabolic process#GO:0061014;regulation of RNA metabolic process#GO:0051252;regulation of RNA stability#GO:0043487 CCR4-NOT complex#GO:0030014;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;P-body#GO:0000932;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228 RNA metabolism protein#PC00031;RNA processing factor#PC00147;mRNA polyadenylation factor#PC00146 HUMAN|HGNC=26088|UniProtKB=Q3BBV0 Q3BBV0 NBPF1 PTHR14199:SF35 NEUROBLASTOMA BREAKPOINT FAMILY MEMBER 6-LIKE PROTEIN NBPF FAMILY MEMBER NBPF1-RELATED HUMAN|HGNC=25090|UniProtKB=Q96DG6 Q96DG6 CMBL PTHR46812:SF1 CARBOXYMETHYLENEBUTENOLIDASE HOMOLOG CARBOXYMETHYLENEBUTENOLIDASE HOMOLOG HUMAN|HGNC=19274|UniProtKB=Q8N0Z6 Q8N0Z6 TTC5 PTHR26312:SF87 TETRATRICOPEPTIDE REPEAT PROTEIN 5 TETRATRICOPEPTIDE REPEAT PROTEIN 5 HUMAN|HGNC=8355|UniProtKB=Q96RD1 Q96RD1 OR6C1 PTHR26454:SF27 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 6C1 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=30417|UniProtKB=Q9NRF2 Q9NRF2 SH2B1 PTHR10872:SF3 SH2B ADAPTER PROTEIN SH2B ADAPTER PROTEIN 1 protein-macromolecule adaptor activity#GO:0030674;protein tyrosine kinase binding#GO:1990782;signaling receptor binding#GO:0005102;binding#GO:0005488;kinase binding#GO:0019900;transmembrane receptor protein tyrosine kinase adaptor activity#GO:0005068;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;protein binding#GO:0005515;signaling adaptor activity#GO:0035591;molecular adaptor activity#GO:0060090;signaling receptor complex adaptor activity#GO:0030159;receptor tyrosine kinase binding#GO:0030971 signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HUMAN|HGNC=28370|UniProtKB=Q9BTN0 Q9BTN0 LRFN3 PTHR45842:SF5 SYNAPTIC ADHESION-LIKE MOLECULE SALM LEUCINE-RICH REPEAT AND FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN 3 presynaptic active zone membrane#GO:0048787;membrane#GO:0016020;cell periphery#GO:0071944;presynapse#GO:0098793;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;plasma membrane region#GO:0098590;presynaptic membrane#GO:0042734;plasma membrane#GO:0005886;synaptic membrane#GO:0097060;presynaptic active zone#GO:0048786;cell junction#GO:0030054 cell adhesion molecule#PC00069;immunoglobulin superfamily cell adhesion molecule#PC00125 HUMAN|HGNC=12978|UniProtKB=Q16670 Q16670 ZSCAN26 PTHR23226:SF56 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 26 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=2290|UniProtKB=O60397 O60397 COX7A2P2 PTHR10510:SF15 CYTOCHROME C OXIDASE POLYPEPTIDE 7A CYTOCHROME C OXIDASE SUBUNIT 7A3, MITOCHONDRIAL-RELATED protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 oxidative phosphorylation#GO:0006119;cellular respiration#GO:0045333;energy derivation by oxidation of organic compounds#GO:0015980;aerobic respiration#GO:0009060;metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091;cellular process#GO:0009987 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;organelle envelope#GO:0031967;mitochondrial envelope#GO:0005740;mitochondrion#GO:0005739;respiratory chain complex#GO:0098803;mitochondrial membrane#GO:0031966;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 oxidase#PC00175;oxidoreductase#PC00176 HUMAN|HGNC=20514|UniProtKB=Q8N257 Q8N257 H2BC26 PTHR23428:SF167 HISTONE H2B HISTONE H2B TYPE 3-B immune response#GO:0006955;defense response to symbiont#GO:0140546;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;response to other organism#GO:0051707;defense response to other organism#GO:0098542;humoral immune response#GO:0006959;antimicrobial humoral response#GO:0019730;defense response#GO:0006952;response to external stimulus#GO:0009605;antibacterial humoral response#GO:0019731;innate immune response#GO:0045087;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to stimulus#GO:0050896;defense response to bacterium#GO:0042742;response to bacterium#GO:0009617;immune system process#GO:0002376;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=14197|UniProtKB=Q9H777 Q9H777 ELAC1 PTHR46018:SF2 ZINC PHOSPHODIESTERASE ELAC PROTEIN 1 ZINC PHOSPHODIESTERASE ELAC PROTEIN 1 RNA nuclease activity#GO:0004540;endonuclease activity#GO:0004519;catalytic activity, acting on RNA#GO:0140098;RNA endonuclease activity#GO:0004521;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;nuclease activity#GO:0004518;catalytic activity, acting on a tRNA#GO:0140101 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 phosphodiesterase#PC00185 HUMAN|HGNC=16713|UniProtKB=O75494 O75494 SRSF10 PTHR23147:SF5 SERINE/ARGININE RICH SPLICING FACTOR SERINE_ARGININE-RICH SPLICING FACTOR 10 ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;nuclear body#GO:0016604;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membraneless organelle#GO:0043228;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear speck#GO:0016607;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 RNA splicing factor#PC00148;RNA metabolism protein#PC00031;RNA processing factor#PC00147 HUMAN|HGNC=1565|UniProtKB=O00590 O00590 ACKR2 PTHR10489:SF942 CELL ADHESION MOLECULE ATYPICAL CHEMOKINE RECEPTOR 2 cytokine receptor activity#GO:0004896;signaling receptor activity#GO:0038023;cytokine binding#GO:0019955;G protein-coupled receptor activity#GO:0004930;immune receptor activity#GO:0140375;transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488;protein binding#GO:0005515;molecular transducer activity#GO:0060089 cellular process#GO:0009987;immune response#GO:0006955;signal transduction#GO:0007165;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;cell migration#GO:0016477;taxis#GO:0042330;response to chemical#GO:0042221;calcium-mediated signaling#GO:0019722;response to external stimulus#GO:0009605;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;locomotion#GO:0040011;signaling#GO:0023052;cell motility#GO:0048870;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;chemotaxis#GO:0006935;cellular response to chemical stimulus#GO:0070887;positive regulation of cytosolic calcium ion concentration#GO:0007204;immune system process#GO:0002376;intracellular signal transduction#GO:0035556;regulation of biological quality#GO:0065008;cell chemotaxis#GO:0060326;cell communication#GO:0007154 cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020;plasma membrane#GO:0005886;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;cell surface#GO:0009986 cell adhesion molecule#PC00069 HUMAN|HGNC=25599|UniProtKB=Q3KP66 Q3KP66 INAVA PTHR16093:SF4 COILED-COIL DOMAIN-CONTAINING PROTEIN 120 FAMILY MEMBER INNATE IMMUNITY ACTIVATOR PROTEIN cell-cell junction organization#GO:0045216;regulation of protein ubiquitination#GO:0031396;regulation of protein modification process#GO:0031399;cellular component organization or biogenesis#GO:0071840;cell-cell junction maintenance#GO:0045217;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of protein ubiquitination#GO:0031398;positive regulation of protein metabolic process#GO:0051247;regulation of post-translational protein modification#GO:1901873;positive regulation of metabolic process#GO:0009893;regulation of biological process#GO:0050789;adherens junction organization#GO:0034332;cellular component organization#GO:0016043;regulation of protein modification by small protein conjugation or removal#GO:1903320;regulation of macromolecule metabolic process#GO:0060255;cell junction organization#GO:0034330;regulation of cellular process#GO:0050794 HUMAN|HGNC=23733|UniProtKB=A2A3N6 A2A3N6 PIPSL PTHR23086:SF116 PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE PIP5K1A AND PSMD4-LIKE PROTEIN-RELATED lipid kinase activity#GO:0001727;phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphatidylinositol kinase activity#GO:0052742;transferase activity#GO:0016740;catalytic activity#GO:0003824 organophosphate biosynthetic process#GO:0090407;phosphatidylinositol phosphate biosynthetic process#GO:0046854;phospholipid metabolic process#GO:0006644;glycerolipid metabolic process#GO:0046486;phospholipid biosynthetic process#GO:0008654;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;glycerophospholipid biosynthetic process#GO:0046474;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;biosynthetic process#GO:0009058;glycerophospholipid metabolic process#GO:0006650;lipid biosynthetic process#GO:0008610;glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 kinase#PC00137;transferase#PC00220 HUMAN|HGNC=12144|UniProtKB=A0A075B6T7 A0A075B6T7 TRAV6 PTHR19433:SF121 T-CELL RECEPTOR ALPHA CHAIN V REGION-RELATED T CELL RECEPTOR ALPHA VARIABLE 6 response to stimulus#GO:0050896;response to external stimulus#GO:0009605;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to other organism#GO:0051707;response to bacterium#GO:0009617;response to biotic stimulus#GO:0009607 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=9807|UniProtKB=O75943 O75943 RAD17 PTHR12172:SF2 CELL CYCLE CHECKPOINT PROTEIN RAD17 CELL CYCLE CHECKPOINT PROTEIN RAD17 chromatin-protein adaptor activity#GO:0140463;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 DNA damage checkpoint signaling#GO:0000077;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;DNA integrity checkpoint signaling#GO:0031570;regulation of cell cycle G2/M phase transition#GO:1902749;mitotic G2/M transition checkpoint#GO:0044818;mitotic DNA integrity checkpoint signaling#GO:0044774;regulation of mitotic cell cycle#GO:0007346;macromolecule metabolic process#GO:0043170;mitotic cell cycle process#GO:1903047;DNA repair#GO:0006281;negative regulation of cellular process#GO:0048523;DNA damage response#GO:0006974;negative regulation of cell cycle process#GO:0010948;mitotic cell cycle#GO:0000278;regulation of cellular process#GO:0050794;mitotic cell cycle checkpoint signaling#GO:0007093;cell cycle#GO:0007049;regulation of cell cycle phase transition#GO:1901987;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular response to stimulus#GO:0051716;mitotic DNA damage checkpoint signaling#GO:0044773;regulation of G2/M transition of mitotic cell cycle#GO:0010389;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cell cycle checkpoint signaling#GO:0000075;negative regulation of mitotic cell cycle phase transition#GO:1901991;negative regulation of G2/M transition of mitotic cell cycle#GO:0010972;regulation of cell cycle process#GO:0010564;response to stress#GO:0006950;signal transduction#GO:0007165;cellular process#GO:0009987;negative regulation of cell cycle#GO:0045786;DNA replication checkpoint signaling#GO:0000076;negative regulation of cell cycle G2/M phase transition#GO:1902750;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;response to stimulus#GO:0050896;signaling#GO:0023052;regulation of cell cycle#GO:0051726;negative regulation of biological process#GO:0048519;negative regulation of cell cycle phase transition#GO:1901988;signal transduction in response to DNA damage#GO:0042770;regulation of biological process#GO:0050789;mitotic DNA replication checkpoint signaling#GO:0033314;cell cycle process#GO:0022402;regulation of mitotic cell cycle phase transition#GO:1901990;mitotic intra-S DNA damage checkpoint signaling#GO:0031573;negative regulation of mitotic cell cycle#GO:0045930;cellular response to stress#GO:0033554 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;chromosome, telomeric repeat region#GO:0140445;membrane-bounded organelle#GO:0043227;site of DNA damage#GO:0090734;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;chromosome, telomeric region#GO:0000781;site of double-strand break#GO:0035861;nucleus#GO:0005634;chromatin#GO:0000785;membraneless organelle#GO:0043228 HUMAN|HGNC=25216|UniProtKB=Q9NUQ9 Q9NUQ9 CYRIB PTHR12422:SF3 GH09096P CYFIP-RELATED RAC1 INTERACTOR B regulation of lymphocyte activation#GO:0051249;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of cell-cell adhesion#GO:0022407;regulation of biological process#GO:0050789;positive regulation of multicellular organismal process#GO:0051240;positive regulation of cell adhesion#GO:0045785;regulation of cell activation#GO:0050865;regulation of leukocyte activation#GO:0002694;positive regulation of lymphocyte activation#GO:0051251;biological regulation#GO:0065007;positive regulation of leukocyte cell-cell adhesion#GO:1903039;positive regulation of cell activation#GO:0050867;regulation of multicellular organismal process#GO:0051239;positive regulation of T cell activation#GO:0050870;regulation of T cell activation#GO:0050863;regulation of cell adhesion#GO:0030155;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of cell-cell adhesion#GO:0022409;positive regulation of immune system process#GO:0002684;positive regulation of leukocyte activation#GO:0002696;regulation of leukocyte cell-cell adhesion#GO:1903037 HUMAN|HGNC=15451|UniProtKB=Q8NBJ4 Q8NBJ4 GOLM1 PTHR15896:SF8 GOLGI PHOSPHOPROTEIN 2/GP73-RELATED GOLGI MEMBRANE PROTEIN 1 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794 HUMAN|HGNC=12222|UniProtKB=A0A597 A0A597 TRBV5-5 PTHR23268:SF6 T-CELL RECEPTOR BETA CHAIN T CELL RECEPTOR BETA VARIABLE 5-5-RELATED cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=23494|UniProtKB=Q8IU99 Q8IU99 CALHM1 PTHR32261:SF2 CALCIUM HOMEOSTASIS MODULATOR PROTEIN CALCIUM HOMEOSTASIS MODULATOR PROTEIN 1 monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic cation channel activity#GO:0005261 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 voltage-gated ion channel#PC00241 HUMAN|HGNC=24275|UniProtKB=Q8NBX0 Q8NBX0 SCCPDH PTHR12286:SF5 SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE biosynthetic process#GO:0009058;liposaccharide metabolic process#GO:1903509;glycolipid metabolic process#GO:0006664;lipid biosynthetic process#GO:0008610;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;primary metabolic process#GO:0044238;glycolipid biosynthetic process#GO:0009247;carbohydrate derivative biosynthetic process#GO:1901137;lipid metabolic process#GO:0006629;metabolic process#GO:0008152 intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membraneless organelle#GO:0043228;lipid droplet#GO:0005811;intracellular membraneless organelle#GO:0043232;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=35153|UniProtKB=A6NFU0 A6NFU0 FAM187A PTHR32178:SF7 FAM187 IG-LIKE V-TYPE DOMAIN-CONTAINING PROTEIN FAM187A immunoglobulin superfamily cell adhesion molecule#PC00125 HUMAN|HGNC=23434|UniProtKB=Q5T5M9 Q5T5M9 CCNJ PTHR10177:SF62 CYCLINS CYCLIN-J enzyme regulator activity#GO:0030234;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;cyclin-dependent protein kinase regulator activity#GO:0019914;protein kinase regulator activity#GO:0019887;cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538 cell cycle phase transition#GO:0044770;mitotic cell cycle#GO:0000278;cell cycle#GO:0007049;cell cycle process#GO:0022402;cellular process#GO:0009987;cell cycle G1/S phase transition#GO:0044843;mitotic cell cycle process#GO:1903047;G1/S transition of mitotic cell cycle#GO:0000082;mitotic cell cycle phase transition#GO:0044772 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554;nucleus#GO:0005634;microtubule cytoskeleton#GO:0015630;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;protein-containing complex#GO:0032991;transferase complex#GO:1990234;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;protein kinase complex#GO:1902911;membraneless organelle#GO:0043228 kinase activator#PC00138 HUMAN|HGNC=3467|UniProtKB=P03372 P03372 ESR1 PTHR48092:SF16 KNIRPS-RELATED PROTEIN-RELATED ESTROGEN RECEPTOR transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;signaling receptor activity#GO:0038023;sequence-specific DNA binding#GO:0043565;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;nuclear receptor activity#GO:0004879;cis-regulatory region sequence-specific DNA binding#GO:0000987;molecular transducer activity#GO:0060089;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;nuclear receptor-mediated steroid hormone signaling pathway#GO:0030518;nuclear receptor-mediated signaling pathway#GO:0141193;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;response to steroid hormone#GO:0048545;regulation of DNA-templated transcription#GO:0006355;cell communication#GO:0007154;regulation of RNA metabolic process#GO:0051252;intracellular signal transduction#GO:0035556;cellular response to stimulus#GO:0051716;steroid hormone receptor signaling pathway#GO:0043401;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;intracellular receptor signaling pathway#GO:0030522;cellular response to steroid hormone stimulus#GO:0071383;response to hormone#GO:0009725;cellular process#GO:0009987;signal transduction#GO:0007165;response to lipid#GO:0033993;cellular response to lipid#GO:0071396;response to chemical#GO:0042221;cellular response to chemical stimulus#GO:0070887;hormone-mediated signaling pathway#GO:0009755;estrogen receptor signaling pathway#GO:0030520;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;cellular response to hormone stimulus#GO:0032870;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;signaling#GO:0023052 chromosome#GO:0005694;nucleus#GO:0005634;chromatin#GO:0000785;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 C4 zinc finger nuclear receptor#PC00169;zinc finger transcription factor#PC00244 HUMAN|HGNC=26585|UniProtKB=Q14D33 Q14D33 RTP5 PTHR14402:SF2 RECEPTOR TRANSPORTING PROTEIN RECEPTOR-TRANSPORTING PROTEIN 5 G protein-coupled receptor binding#GO:0001664;binding#GO:0005488;signaling receptor binding#GO:0005102;protein binding#GO:0005515 cellular component organization#GO:0016043;sensory perception of bitter taste#GO:0050913;detection of chemical stimulus#GO:0009593;protein targeting#GO:0006605;response to stimulus#GO:0050896;detection of chemical stimulus involved in sensory perception#GO:0050907;detection of chemical stimulus involved in sensory perception of taste#GO:0050912;nervous system process#GO:0050877;sensory perception#GO:0007600;localization within membrane#GO:0051668;cellular localization#GO:0051641;localization#GO:0051179;macromolecule localization#GO:0033036;detection of stimulus#GO:0051606;establishment of protein localization to membrane#GO:0090150;detection of stimulus involved in sensory perception#GO:0050906;cellular process#GO:0009987;establishment of protein localization#GO:0045184;multicellular organismal process#GO:0032501;response to chemical#GO:0042221;protein insertion into membrane#GO:0051205;membrane organization#GO:0061024;sensory perception of chemical stimulus#GO:0007606;protein targeting to membrane#GO:0006612;sensory perception of taste#GO:0050909;detection of chemical stimulus involved in sensory perception of bitter taste#GO:0001580;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;intracellular protein localization#GO:0008104;system process#GO:0003008 membrane traffic protein#PC00150 HUMAN|HGNC=4288|UniProtKB=O95452 O95452 GJB6 PTHR11984:SF23 CONNEXIN GAP JUNCTION BETA-6 PROTEIN transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;channel activity#GO:0015267;wide pore channel activity#GO:0022829 biological regulation#GO:0065007;cell-cell signaling#GO:0007267;signaling#GO:0023052;cellular process#GO:0009987;regulation of biological process#GO:0050789;establishment of localization#GO:0051234;cell communication#GO:0007154;localization#GO:0051179;transport#GO:0006810 anchoring junction#GO:0070161;cell junction#GO:0030054;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;cell-cell junction#GO:0005911;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 gap junction#PC00105;cell junction protein#PC00070 HUMAN|HGNC=11396|UniProtKB=O94768 O94768 STK17B PTHR24342:SF5 SERINE/THREONINE-PROTEIN KINASE 17 SERINE_THREONINE-PROTEIN KINASE 17B catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 positive regulation of apoptotic process#GO:0043065;regulation of apoptotic process#GO:0042981;biological regulation#GO:0065007;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of cellular process#GO:0050794;positive regulation of programmed cell death#GO:0043068;response to stimulus#GO:0050896;signaling#GO:0023052;regulation of programmed cell death#GO:0043067;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=8634|UniProtKB=P40426 P40426 PBX3 PTHR11850:SF97 HOMEOBOX PROTEIN TRANSCRIPTION FACTORS PRE-B-CELL LEUKEMIA TRANSCRIPTION FACTOR 3 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;sequence-specific DNA binding#GO:0043565;DNA-binding transcription activator activity#GO:0001216;transcription regulator activity#GO:0140110;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulatory region nucleic acid binding#GO:0001067 cell development#GO:0048468;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;central nervous system development#GO:0007417;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;eye development#GO:0001654;neuron development#GO:0048666;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;embryo development#GO:0009790;head development#GO:0060322;nervous system development#GO:0007399;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;sensory system development#GO:0048880;animal organ development#GO:0048513;multicellular organism development#GO:0007275;neuron differentiation#GO:0030182;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of RNA metabolic process#GO:0051254;visual system development#GO:0150063;animal organ morphogenesis#GO:0009887;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;positive regulation of biosynthetic process#GO:0009891;embryonic organ development#GO:0048568;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;positive regulation of DNA-templated transcription#GO:0045893;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;brain development#GO:0007420;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;developmental process#GO:0032502;sensory organ development#GO:0007423 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=18258|UniProtKB=Q9HBM0 Q9HBM0 VEZT PTHR15989:SF5 VEZATIN VEZATIN cell-cell adhesion#GO:0098609;cellular process#GO:0009987;cell adhesion#GO:0007155 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HUMAN|HGNC=2219|UniProtKB=Q14050 Q14050 COL9A3 PTHR24023:SF866 COLLAGEN ALPHA COLLAGEN ALPHA-3(IX) CHAIN extracellular matrix structural constituent#GO:0005201;structural molecule activity#GO:0005198 extracellular structure organization#GO:0043062;cellular component organization#GO:0016043;cellular process#GO:0009987;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;external encapsulating structure organization#GO:0045229 interstitial matrix#GO:0005614;supramolecular complex#GO:0099080;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;basement membrane#GO:0005604;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular protein-containing complex#GO:0140392;extracellular region#GO:0005576 extracellular matrix structural protein#PC00103;extracellular matrix protein#PC00102 Integrin signalling pathway#P00034>Collagen#P00922 HUMAN|HGNC=29297|UniProtKB=Q6P9A1 Q6P9A1 ZNF530 PTHR24377:SF1036 IP01015P-RELATED ZINC FINGER PROTEIN 530 cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=6546|UniProtKB=Q14746 Q14746 COG2 PTHR12961:SF0 CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 2 CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 2 endomembrane system organization#GO:0010256;vesicle-mediated transport#GO:0016192;intra-Golgi vesicle-mediated transport#GO:0006891;cellular process#GO:0009987;Golgi organization#GO:0007030;cellular component organization#GO:0016043;organelle organization#GO:0006996;establishment of localization#GO:0051234;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;Golgi vesicle transport#GO:0048193;transport#GO:0006810 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;vesicle tethering complex#GO:0099023;membrane-bounded organelle#GO:0043227;COG complex#GO:0017119;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;organelle#GO:0043226 HUMAN|HGNC=13431|UniProtKB=P0CI25 P0CI25 TRIM49 PTHR24103:SF637 E3 UBIQUITIN-PROTEIN LIGASE TRIM TRIPARTITE MOTIF-CONTAINING PROTEIN 49-RELATED ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740 immune system process#GO:0002376;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;regulation of biosynthetic process#GO:0009889;innate immune response#GO:0045087;regulation of gene expression#GO:0010468;defense response#GO:0006952;response to external stimulus#GO:0009605;regulation of macromolecule biosynthetic process#GO:0010556;response to stress#GO:0006950;regulation of metabolic process#GO:0019222;response to biotic stimulus#GO:0009607;immune response#GO:0006955;defense response to symbiont#GO:0140546;defense response to other organism#GO:0098542;response to other organism#GO:0051707;biological regulation#GO:0065007 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=10071|UniProtKB=O76064 O76064 RNF8 PTHR15067:SF9 E3 UBIQUITIN-PROTEIN LIGASE RNF8 E3 UBIQUITIN-PROTEIN LIGASE RNF8 histone binding#GO:0042393;catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;binding#GO:0005488;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;protein binding#GO:0005515 DNA metabolic process#GO:0006259;macromolecule catabolic process#GO:0009057;DNA repair#GO:0006281;protein K48-linked ubiquitination#GO:0070936;metabolic process#GO:0008152;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;double-strand break repair#GO:0006302;response to stress#GO:0006950;cellular process#GO:0009987;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;nucleobase-containing compound metabolic process#GO:0006139;protein modification by small protein conjugation or removal#GO:0070647;modification-dependent macromolecule catabolic process#GO:0043632;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;nucleic acid metabolic process#GO:0090304;protein modification process#GO:0036211;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;modification-dependent protein catabolic process#GO:0019941;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;response to stimulus#GO:0050896;catabolic process#GO:0009056 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;chromosome#GO:0005694;site of DNA damage#GO:0090734;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ubiquitin ligase complex#GO:0000151;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;site of double-strand break#GO:0035861;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;transferase complex#GO:1990234 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=1554|UniProtKB=O00257 O00257 CBX4 PTHR46727:SF1 E3 SUMO-PROTEIN LIGASE CBX4 E3 SUMO-PROTEIN LIGASE CBX4 SUMO ligase activity#GO:0061665;SUMO transferase activity#GO:0019789;ubiquitin-like protein transferase activity#GO:0019787;binding#GO:0005488;acyltransferase activity#GO:0016746;ubiquitin-like protein ligase activity#GO:0061659;protein binding#GO:0005515;catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 regulation of nucleobase-containing compound metabolic process#GO:0019219;post-translational protein modification#GO:0043687;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein metabolic process#GO:0019538;regulation of DNA-templated transcription#GO:0006355;macromolecule modification#GO:0043412;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;protein sumoylation#GO:0016925;metabolic process#GO:0008152;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;protein modification by small protein conjugation#GO:0032446;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;protein modification by small protein conjugation or removal#GO:0070647 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ubiquitin ligase complex#GO:0000151;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear ubiquitin ligase complex#GO:0000152;intracellular membrane-bounded organelle#GO:0043231;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;PRC1 complex#GO:0035102;intracellular protein-containing complex#GO:0140535;PcG protein complex#GO:0031519;nucleus#GO:0005634;protein-containing complex#GO:0032991 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=4341|UniProtKB=P15104 P15104 GLUL PTHR20852:SF45 GLUTAMINE SYNTHETASE GLUTAMINE SYNTHETASE ligase activity, forming carbon-nitrogen bonds#GO:0016879;catalytic activity#GO:0003824;ligase activity#GO:0016874 proteinogenic amino acid biosynthetic process#GO:0170038;amino acid biosynthetic process#GO:0008652;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;small molecule biosynthetic process#GO:0044283;proteinogenic amino acid metabolic process#GO:0170039;small molecule metabolic process#GO:0044281;amino acid metabolic process#GO:0006520;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;carboxylic acid biosynthetic process#GO:0046394;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 ligase#PC00142 Glutamine glutamate conversion#P02745>Glutamine synthetase#P02968;Glutamine glutamate conversion#P02745>Glutamine synthase#P04483 HUMAN|HGNC=14013|UniProtKB=Q9NTJ3 Q9NTJ3 SMC4 PTHR43939:SF130 COILED-COIL DOMAIN-CONTAINING PROTEIN 158 STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 4 cellular component organization#GO:0016043;nuclear chromosome segregation#GO:0098813;sister chromatid segregation#GO:0000819;meiotic cell cycle process#GO:1903046;cell cycle#GO:0007049;mitotic nuclear division#GO:0140014;cell cycle process#GO:0022402;mitotic cell cycle#GO:0000278;reproductive process#GO:0022414;nuclear division#GO:0000280;sexual reproduction#GO:0019953;organelle fission#GO:0048285;chromosome condensation#GO:0030261;mitotic chromosome condensation#GO:0007076;mitotic sister chromatid segregation#GO:0000070;organelle organization#GO:0006996;cellular process#GO:0009987;meiotic cell cycle#GO:0051321;chromosome segregation#GO:0007059;meiotic nuclear division#GO:0140013;cellular component organization or biogenesis#GO:0071840;chromosome organization#GO:0051276;meiotic chromosome segregation#GO:0045132;mitotic cell cycle process#GO:1903047 nucleus#GO:0005634;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;condensin complex#GO:0000796;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228 HUMAN|HGNC=12143|UniProtKB=A0A0B4J249 A0A0B4J249 TRAV5 PTHR19433:SF76 T-CELL RECEPTOR ALPHA CHAIN V REGION-RELATED T CELL RECEPTOR ALPHA VARIABLE 5 response to bacterium#GO:0009617;response to biotic stimulus#GO:0009607;response to other organism#GO:0051707;biological process involved in interspecies interaction between organisms#GO:0044419;response to external stimulus#GO:0009605;response to external biotic stimulus#GO:0043207;response to stimulus#GO:0050896 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=15291|UniProtKB=Q96RB7 Q96RB7 OR5M11 PTHR48018:SF106 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5M11 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;signal transduction#GO:0007165;cellular process#GO:0009987;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;sensory perception#GO:0007600;nervous system process#GO:0050877;response to stimulus#GO:0050896;sensory perception of smell#GO:0007608;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=29235|UniProtKB=Q9ULE4 Q9ULE4 FAM184B PTHR18870:SF8 PROTEIN TAG-278-RELATED PROTEIN FAM184B HUMAN|HGNC=18981|UniProtKB=Q8N165 Q8N165 PDIK1L PTHR11042:SF58 EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED SERINE_THREONINE-PROTEIN KINASE PDIK1L phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 post-transcriptional regulation of gene expression#GO:0010608;regulation of translational initiation#GO:0006446;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=9045|UniProtKB=Q6DJT9 Q6DJT9 PLAG1 PTHR24388:SF69 ZINC FINGER PROTEIN ZINC FINGER PROTEIN PLAG1 cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=18081|UniProtKB=Q9Y5W5 Q9Y5W5 WIF1 PTHR14949:SF32 EGF-LIKE-DOMAIN, MULTIPLE 7, 8 WNT INHIBITORY FACTOR 1 binding#GO:0005488;signaling receptor binding#GO:0005102;receptor serine/threonine kinase binding#GO:0033612;protein binding#GO:0005515 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165;cell surface#GO:0009986 intercellular signal molecule#PC00207 HUMAN|HGNC=30476|UniProtKB=Q8WXB1 Q8WXB1 METTL21A PTHR14614:SF14 HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN PROTEIN N-LYSINE METHYLTRANSFERASE METTL21A catalytic activity, acting on a protein#GO:0140096;protein methyltransferase activity#GO:0008276;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity#GO:0003824;transferase activity#GO:0016740;lysine N-methyltransferase activity#GO:0016278;N-methyltransferase activity#GO:0008170;protein-lysine N-methyltransferase activity#GO:0016279;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260 HUMAN|HGNC=9854|UniProtKB=P46060 P46060 RANGAP1 PTHR24113:SF12 RAN GTPASE-ACTIVATING PROTEIN 1 RAN GTPASE-ACTIVATING PROTEIN 1 molecular function activator activity#GO:0140677;protein binding#GO:0005515;small GTPase binding#GO:0031267;enzyme regulator activity#GO:0030234;enzyme binding#GO:0019899;binding#GO:0005488;molecular function regulator activity#GO:0098772;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047 cellular process#GO:0009987;establishment of localization in cell#GO:0051649;nucleocytoplasmic transport#GO:0006913;transport#GO:0006810;intracellular transport#GO:0046907;nuclear export#GO:0051168;nuclear transport#GO:0051169;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;perinuclear region of cytoplasm#GO:0048471;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;cytosol#GO:0005829 GTPase-activating protein#PC00257;protein-binding activity modulator#PC00095 HUMAN|HGNC=10751|UniProtKB=P49908 P49908 SELENOP PTHR10105:SF3 SELENOPROTEIN P SELENOPROTEIN P extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=26431|UniProtKB=Q6BAA4 Q6BAA4 FCRLB PTHR11481:SF94 IMMUNOGLOBULIN FC RECEPTOR FC RECEPTOR-LIKE B signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;immune response#GO:0006955;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;immune system process#GO:0002376;cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154 cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020;plasma membrane#GO:0005886;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;cell surface#GO:0009986 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=31750|UniProtKB=Q8N8I0 Q8N8I0 SAMD12 PTHR20843:SF2 STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 10 STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 12 cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cell surface receptor signaling pathway#GO:0007166;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 cytoplasmic side of plasma membrane#GO:0009898;membrane#GO:0016020;cytoplasmic side of membrane#GO:0098562;cell periphery#GO:0071944;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HUMAN|HGNC=263|UniProtKB=P29274 P29274 ADORA2A PTHR24246:SF47 OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR ADENOSINE RECEPTOR A2A G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 cell surface receptor signaling pathway#GO:0007166;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;cellular process#GO:0009987;synaptic transmission, dopaminergic#GO:0001963;signal transduction#GO:0007165;synaptic signaling#GO:0099536;cell communication#GO:0007154;G protein-coupled adenosine receptor signaling pathway#GO:0001973;trans-synaptic signaling#GO:0099537;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;anterograde trans-synaptic signaling#GO:0098916;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GoPCR#P00725;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711 HUMAN|HGNC=17883|UniProtKB=Q8NFT6 Q8NFT6 DBF4B PTHR15375:SF24 ACTIVATOR OF S-PHASE KINASE-RELATED PROTEIN DBF4 HOMOLOG B kinase activator activity#GO:0019209;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;protein kinase activator activity#GO:0030295;enzyme activator activity#GO:0008047;protein serine/threonine kinase activator activity#GO:0043539;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;protein kinase regulator activity#GO:0019887 positive regulation of cell cycle#GO:0045787;regulation of cell cycle process#GO:0010564;biological regulation#GO:0065007;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA replication#GO:0045740;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of cell cycle#GO:0051726;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of DNA metabolic process#GO:0051052;regulation of DNA-templated DNA replication#GO:0090329;regulation of biological process#GO:0050789;positive regulation of cell cycle process#GO:0090068;positive regulation of DNA metabolic process#GO:0051054;regulation of cell cycle phase transition#GO:1901987;regulation of DNA replication#GO:0006275;positive regulation of metabolic process#GO:0009893 transferase complex, transferring phosphorus-containing groups#GO:0061695;transferase complex#GO:1990234;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;nuclear protein-containing complex#GO:0140513;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;protein kinase complex#GO:1902911;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 kinase activator#PC00138;kinase modulator#PC00140 HUMAN|HGNC=13241|UniProtKB=Q9H4K1 Q9H4K1 RIBC2 PTHR14517:SF10 RIB43A-RELATED RIB43A-LIKE WITH COILED-COILS PROTEIN 2 cytoskeletal protein#PC00085 HUMAN|HGNC=4835|UniProtKB=P02008 P02008 HBZ PTHR11442:SF41 HEMOGLOBIN FAMILY MEMBER HEMOGLOBIN SUBUNIT ZETA tetrapyrrole binding#GO:0046906;heme binding#GO:0020037;molecular carrier activity#GO:0140104;binding#GO:0005488 myeloid cell differentiation#GO:0030099;cell differentiation#GO:0030154;cell development#GO:0048468;homeostatic process#GO:0042592;anatomical structure development#GO:0048856;erythrocyte differentiation#GO:0030218;localization#GO:0051179;immune system process#GO:0002376;homeostasis of number of cells#GO:0048872;multicellular organismal process#GO:0032501;hemopoiesis#GO:0030097;cellular process#GO:0009987;establishment of localization#GO:0051234;cellular developmental process#GO:0048869;multicellular organismal-level homeostasis#GO:0048871;transport#GO:0006810;developmental process#GO:0032502 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 transfer/carrier protein#PC00219;globin#PC00107 HUMAN|HGNC=24253|UniProtKB=Q9Y3B3 Q9Y3B3 TMED7 PTHR22811:SF117 TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN 7 cargo adaptor activity#GO:0140312;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 intracellular protein localization#GO:0008104;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;transport#GO:0006810;intracellular protein transport#GO:0006886;Golgi vesicle transport#GO:0048193;intracellular transport#GO:0046907;endomembrane system organization#GO:0010256;vesicle-mediated transport#GO:0016192;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule localization#GO:0033036;organelle organization#GO:0006996;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;protein transport#GO:0015031;localization#GO:0051179;cellular localization#GO:0051641;Golgi organization#GO:0007030;cellular component organization#GO:0016043 vesicle#GO:0031982;intracellular vesicle#GO:0097708;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;coated vesicle#GO:0030135;COPII-coated ER to Golgi transport vesicle#GO:0030134;cytoplasm#GO:0005737;endomembrane system#GO:0012505;endoplasmic reticulum#GO:0005783;Golgi apparatus#GO:0005794 membrane traffic protein#PC00150;vesicle coat protein#PC00235 HUMAN|HGNC=28469|UniProtKB=Q9BV20 Q9BV20 MRI1 PTHR43475:SF1 METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE catalytic activity#GO:0003824;intramolecular oxidoreductase activity, interconverting aldoses and ketoses#GO:0016861;intramolecular oxidoreductase activity#GO:0016860;isomerase activity#GO:0016853 nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;proteinogenic amino acid metabolic process#GO:0170039;nucleobase-containing compound metabolic process#GO:0006139;amino acid metabolic process#GO:0006520;sulfur compound metabolic process#GO:0006790;carbohydrate derivative metabolic process#GO:1901135;homocysteine metabolic process#GO:0050667;cellular process#GO:0009987;oxoacid metabolic process#GO:0043436;purine nucleoside metabolic process#GO:0042278;small molecule metabolic process#GO:0044281;nucleoside metabolic process#GO:0009116;modified amino acid metabolic process#GO:0006575;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;purine-containing compound metabolic process#GO:0072521 isomerase#PC00135 HUMAN|HGNC=31816|UniProtKB=P0C7M6 P0C7M6 IQCF3 PTHR21633:SF5 IQ MOTIF CONTAINING F IQ DOMAIN-CONTAINING PROTEIN F3 HUMAN|HGNC=17887|UniProtKB=Q9UQ10 Q9UQ10 DHDH PTHR22604:SF105 OXIDOREDUCTASES TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824 cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate metabolic process#GO:0005975;small molecule catabolic process#GO:0044282;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;metabolic process#GO:0008152;monosaccharide metabolic process#GO:0005996;carbohydrate catabolic process#GO:0016052 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=6482|UniProtKB=P24043 P24043 LAMA2 PTHR10574:SF291 NETRIN/LAMININ-RELATED LAMININ SUBUNIT ALPHA-2 extracellular matrix structural constituent#GO:0005201;structural molecule activity#GO:0005198 cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell development#GO:0048468;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;neuron development#GO:0048666;axonogenesis#GO:0007409;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;multicellular organismal process#GO:0032501;tissue development#GO:0009888;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;axon guidance#GO:0007411;axon development#GO:0061564;neuron projection development#GO:0031175;cellular process#GO:0009987;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;neurogenesis#GO:0022008;neuron projection guidance#GO:0097485;cell projection morphogenesis#GO:0048858;neuron projection morphogenesis#GO:0048812;plasma membrane bounded cell projection morphogenesis#GO:0120039;developmental process#GO:0032502;neuron differentiation#GO:0030182 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576;basement membrane#GO:0005604;cellular anatomical structure#GO:0110165 extracellular matrix protein#PC00102 Integrin signalling pathway#P00034>Laminin#P00947 HUMAN|HGNC=441|UniProtKB=P10696 P10696 ALPG PTHR11596:SF81 ALKALINE PHOSPHATASE ALKALINE PHOSPHATASE, GERM CELL TYPE phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 phosphatase#PC00181;hydrolase#PC00121 HUMAN|HGNC=33896|UniProtKB=Q6S5H5 Q6S5H5 POTEG PTHR24118:SF56 POTE ANKYRIN DOMAIN POTE ANKYRIN DOMAIN FAMILY MEMBER G-RELATED transcription regulator activity#GO:0140110;transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712 regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;regulation of intracellular signal transduction#GO:1902531;regulation of biological process#GO:0050789;regulation of non-canonical NF-kappaB signal transduction#GO:1901222;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794 intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634 membrane traffic protein#PC00150 HUMAN|HGNC=20397|UniProtKB=Q5U623 Q5U623 ATF7IP2 PTHR23210:SF23 ACTIVATING TRANSCRIPTION FACTOR 7 INTERACTING PROTEIN ACTIVATING TRANSCRIPTION FACTOR 7-INTERACTING PROTEIN 2 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255 nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular anatomical structure#GO:0005622 transcription cofactor#PC00217;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=13579|UniProtKB=Q9Y5B6 Q9Y5B6 PAXBP1 PTHR12214:SF2 GC-RICH SEQUENCE DNA-BINDING FACTOR PAX3- AND PAX7-BINDING PROTEIN 1 regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of transcription by RNA polymerase II#GO:0045944 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=30782|UniProtKB=Q9BXJ9 Q9BXJ9 NAA15 PTHR22767:SF6 N-TERMINAL ACETYLTRANSFERASE-RELATED N-ALPHA-ACETYLTRANSFERASE 15, NATA AUXILIARY SUBUNIT enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047 protein acetyltransferase complex#GO:0031248;transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;acetyltransferase complex#GO:1902493;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737 acetyltransferase#PC00038 HUMAN|HGNC=20523|UniProtKB=P60371 P60371 KRTAP10-6 PTHR23262:SF253 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 10-6 structural protein#PC00211 HUMAN|HGNC=4799|UniProtKB=Q16836 Q16836 HADH PTHR43561:SF3 FAMILY NOT NAMED HYDROXYACYL-COENZYME A DEHYDROGENASE, MITOCHONDRIAL oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 fatty acid beta-oxidation#GO:0006635;lipid metabolic process#GO:0006629;fatty acid oxidation#GO:0019395;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;lipid modification#GO:0030258;cellular process#GO:0009987;lipid catabolic process#GO:0016042;carboxylic acid catabolic process#GO:0046395;monocarboxylic acid catabolic process#GO:0072329;oxoacid metabolic process#GO:0043436;fatty acid catabolic process#GO:0009062;lipid oxidation#GO:0034440;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;monocarboxylic acid metabolic process#GO:0032787;small molecule catabolic process#GO:0044282;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056 HUMAN|HGNC=3214|UniProtKB=P13639 P13639 EEF2 PTHR42908:SF35 TRANSLATION ELONGATION FACTOR-RELATED ELONGATION FACTOR 2 ribonucleoside triphosphate phosphatase activity#GO:0017111;translation elongation factor activity#GO:0003746;hydrolase activity, acting on acid anhydrides#GO:0016817;translation factor activity#GO:0180051;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;ribosome binding#GO:0043022;protein-containing complex binding#GO:0044877;hydrolase activity#GO:0016787;ribonucleoprotein complex binding#GO:0043021;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488 metabolic process#GO:0008152;translational elongation#GO:0006414;translation#GO:0006412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;biosynthetic process#GO:0009058 ribonucleoprotein complex#GO:1990904;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 translation elongation factor#PC00222 HUMAN|HGNC=1569|UniProtKB=P06307 P06307 CCK PTHR10786:SF0 CHOLECYSTOKININ CHOLECYSTOKININ receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;molecular function activator activity#GO:0140677;hormone activity#GO:0005179;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;neuropeptide hormone activity#GO:0005184 digestion#GO:0007586;multicellular organismal process#GO:0032501 plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;neuron projection#GO:0043005;axon#GO:0030424 CCKR signaling map#P06959>CCK-G#P07062;CCKR signaling map#P06959>CCK-GRR#P07131;CCKR signaling map#P06959>CCK#P07077;CCKR signaling map#P06959>CCK-33#P07045;CCKR signaling map#P06959>CCK-22#P07022;CCKR signaling map#P06959>Pro CCK @ TGN#P07174;CCKR signaling map#P06959>CCK-83#P07118;CCKR signaling map#P06959>CCK-8#P07226;CCKR signaling map#P06959>Signal-pre-pro CCK#P07223;CCKR signaling map#P06959>Pre-pro CCK @ ER#P07128;CCKR signaling map#P06959>Pro-CCK @ secretory granule#P07206;CCKR signaling map#P06959>CCK-58#P07164 HUMAN|HGNC=44441|UniProtKB=C9JLJ4 C9JLJ4 USP17L13 PTHR24006:SF651 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE INACTIVE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 17-LIKE PROTEIN 4-RELATED hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;cysteine-type deubiquitinase activity#GO:0004843 regulation of apoptotic process#GO:0042981;regulation of biological process#GO:0050789;regulation of protein stability#GO:0031647;regulation of programmed cell death#GO:0043067;regulation of biological quality#GO:0065008;biological regulation#GO:0065007;regulation of cellular process#GO:0050794 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;cytosol#GO:0005829;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 protease#PC00190;cysteine protease#PC00081 HUMAN|HGNC=27080|UniProtKB=A6NFU8 A6NFU8 PGPEP1L PTHR23402:SF15 PROTEASE FAMILY C15 PYROGLUTAMYL-PEPTIDASE I-RELATED PYROGLUTAMYL-PEPTIDASE 1-LIKE PROTEIN hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;catalytic activity#GO:0003824 cysteine protease#PC00081 HUMAN|HGNC=7404|UniProtKB=Q93083 Q93083 MT1L PTHR23299:SF24 METALLOTHIONEIN METALLOTHIONEIN-1E-RELATED defense/immunity protein#PC00090 HUMAN|HGNC=29499|UniProtKB=Q6P179 Q6P179 ERAP2 PTHR11533:SF239 PROTEASE M1 ZINC METALLOPROTEASE ENDOPLASMIC RETICULUM AMINOPEPTIDASE 2 aminopeptidase activity#GO:0004177;catalytic activity#GO:0003824;metalloexopeptidase activity#GO:0008235;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;metallopeptidase activity#GO:0008237;metalloaminopeptidase activity#GO:0070006;hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238 peptide metabolic process#GO:0006518;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;proteolysis#GO:0006508;catabolic process#GO:0009056;cellular process#GO:0009987;peptide catabolic process#GO:0043171;primary metabolic process#GO:0044238 organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;endoplasmic reticulum lumen#GO:0005788;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 protease#PC00190;metalloprotease#PC00153 HUMAN|HGNC=10971|UniProtKB=Q9Y694 Q9Y694 SLC22A7 PTHR24064:SF33 SOLUTE CARRIER FAMILY 22 MEMBER SOLUTE CARRIER FAMILY 22 MEMBER 7 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 lipid transport#GO:0006869;cellular process#GO:0009987;macromolecule localization#GO:0033036;monocarboxylic acid transport#GO:0015718;fatty acid transport#GO:0015908;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810;carboxylic acid transport#GO:0046942;organic acid transport#GO:0015849;lipid localization#GO:0010876 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 secondary carrier transporter#PC00258 HUMAN|HGNC=1856|UniProtKB=Q02224 Q02224 CENPE PTHR47968:SF83 CENTROMERE PROTEIN E CENTROMERE-ASSOCIATED PROTEIN E protein binding#GO:0005515;binding#GO:0005488;microtubule binding#GO:0008017;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092 cell cycle#GO:0007049;cellular process#GO:0009987;microtubule-based movement#GO:0007018;mitotic cell cycle#GO:0000278;microtubule-based process#GO:0007017 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;microtubule#GO:0005874;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;organelle#GO:0043226;supramolecular complex#GO:0099080 HUMAN|HGNC=9835|UniProtKB=Q9Y5P3 Q9Y5P3 RAI2 PTHR23186:SF3 RETINOIC ACID-INDUCED PROTEIN 2 RETINOIC ACID-INDUCED PROTEIN 2 anatomical structure development#GO:0048856;animal organ development#GO:0048513;developmental process#GO:0032502;animal gross anatomical part developmental process#GO:0160108 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=3066|UniProtKB=O75319 O75319 DUSP11 PTHR10367:SF18 MRNA-CAPPING ENZYME RNA_RNP COMPLEX-1-INTERACTING PHOSPHATASE phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on RNA#GO:0140098;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a nucleic acid#GO:0140640;nucleotidyltransferase activity#GO:0016779;transferase activity, transferring phosphorus-containing groups#GO:0016772;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;hydrolase activity#GO:0016787 RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654 RNA processing factor#PC00147;mRNA capping factor#PC00145 HUMAN|HGNC=17062|UniProtKB=Q5JVS0 Q5JVS0 HABP4 PTHR12299:SF30 HYALURONIC ACID-BINDING PROTEIN 4 INTRACELLULAR HYALURONAN-BINDING PROTEIN 4 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 post-transcriptional regulation of gene expression#GO:0010608;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007;positive regulation of macromolecule metabolic process#GO:0010604;regulation of translational initiation#GO:0006446;positive regulation of protein metabolic process#GO:0051247;positive regulation of translation#GO:0045727;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031 HUMAN|HGNC=24368|UniProtKB=Q9UII4 Q9UII4 HERC5 PTHR45622:SF7 UBIQUITIN-PROTEIN LIGASE E3A-RELATED E3 ISG15--PROTEIN LIGASE HERC5 ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein modification by small protein conjugation or removal#GO:0070647;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein modification process#GO:0036211;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;protein modification by small protein conjugation#GO:0032446;catabolic process#GO:0009056;ISG15-protein conjugation#GO:0032020;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;cellular process#GO:0009987;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=26392|UniProtKB=Q96NR3 Q96NR3 PTCHD1 PTHR10796:SF36 PATCHED-RELATED PATCHED DOMAIN-CONTAINING PROTEIN 1 nervous system process#GO:0050877;cognition#GO:0050890;system process#GO:0003008;multicellular organismal process#GO:0032501 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell junction#GO:0030054 protein-binding activity modulator#PC00095 HUMAN|HGNC=1513|UniProtKB=O14958 O14958 CASQ2 PTHR10033:SF15 CALSEQUESTRIN CALSEQUESTRIN-2 binding#GO:0005488;small molecule binding#GO:0036094;molecular sequestering activity#GO:0140313;ion binding#GO:0043167;calcium ion binding#GO:0005509;metal ion binding#GO:0046872;cation binding#GO:0043169 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of metal ion transport#GO:0010959;regulation of heart contraction#GO:0008016;signaling#GO:0023052;regulation of transmembrane transport#GO:0034762;regulation of muscle system process#GO:0090257;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of muscle contraction#GO:0006937;regulation of monoatomic ion transport#GO:0043269;intracellular signaling cassette#GO:0141124;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;regulation of calcium ion transport#GO:0051924;cellular process#GO:0009987;regulation of monoatomic ion transmembrane transport#GO:0034765;signal transduction#GO:0007165;calcium-mediated signaling#GO:0019722;regulation of release of sequestered calcium ion into cytosol#GO:0051279;regulation of localization#GO:0032879;regulation of transport#GO:0051049;regulation of monoatomic cation transmembrane transport#GO:1904062;regulation of system process#GO:0044057 sarcoplasmic reticulum#GO:0016529;contractile muscle fiber#GO:0043292;Z disc#GO:0030018;endoplasmic reticulum lumen#GO:0005788;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;endomembrane system#GO:0012505;I band#GO:0031674;endoplasmic reticulum#GO:0005783;sarcomere#GO:0030017;membraneless organelle#GO:0043228;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle lumen#GO:0070013;sarcoplasm#GO:0016528;supramolecular fiber#GO:0099512;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;myofibril#GO:0030016 calcium-binding protein#PC00060 HUMAN|HGNC=24959|UniProtKB=Q9BZM3 Q9BZM3 GSX2 PTHR47421:SF1 GS HOMEOBOX 2 GS HOMEOBOX 2 DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116;DNA-binding transcription factor#PC00218 HUMAN|HGNC=494|UniProtKB=Q12955 Q12955 ANK3 PTHR24133:SF62 ANKYRIN DOMAIN-CONTAINING ANKYRIN-3 cytoskeletal protein binding#GO:0008092;cytoskeletal adaptor activity#GO:0008093;molecular adaptor activity#GO:0060090;transmembrane transporter binding#GO:0044325;protein-macromolecule adaptor activity#GO:0030674;binding#GO:0005488;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 intracellular protein localization#GO:0008104;cellular localization#GO:0051641;localization#GO:0051179;localization within membrane#GO:0051668;protein localization to cell periphery#GO:1990778;cellular process#GO:0009987;protein localization to plasma membrane#GO:0072659;protein localization to membrane#GO:0072657;macromolecule localization#GO:0033036 neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020;cell projection#GO:0042995;plasma membrane#GO:0005886;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=23633|UniProtKB=Q9HBL7 Q9HBL7 PLGRKT PTHR13411:SF7 PLASMINOGEN RECEPTOR (KT) PLASMINOGEN RECEPTOR (KT) positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;positive regulation of macromolecule metabolic process#GO:0010604;regulation of proteolysis#GO:0030162;regulation of gene expression#GO:0010468;positive regulation of gene expression#GO:0010628;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of protein metabolic process#GO:0051247;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891 HUMAN|HGNC=28108|UniProtKB=Q9GZT6 Q9GZT6 CCDC90B PTHR14360:SF14 PROTEIN FMP32, MITOCHONDRIAL COILED-COIL DOMAIN-CONTAINING PROTEIN 90B, MITOCHONDRIAL intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=20729|UniProtKB=Q6X9E4 Q6X9E4 FBXW12 PTHR44019:SF17 WD REPEAT-CONTAINING PROTEIN 55 F-BOX_WD REPEAT-CONTAINING PROTEIN 12 non-motor microtubule binding protein#PC00166;cytoskeletal protein#PC00085 HUMAN|HGNC=7452|UniProtKB=Q9NYA4 Q9NYA4 MTMR4 PTHR10807:SF64 MYOTUBULARIN-RELATED PHOSPHATIDYLINOSITOL-3,5-BISPHOSPHATE 3-PHOSPHATASE MTMR4 protein binding#GO:0005515;hydrolase activity#GO:0016787;enzyme binding#GO:0019899;phosphatase binding#GO:0019902;binding#GO:0005488;phosphatidylinositol-3,5-bisphosphate phosphatase activity#GO:0106018;protein phosphatase binding#GO:0019903;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824 lipid modification#GO:0030258;dephosphorylation#GO:0016311;phosphatidylinositol metabolic process#GO:0046488;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;phosphatidylinositol dephosphorylation#GO:0046856;phospholipid metabolic process#GO:0006644;glycerolipid metabolic process#GO:0046486;glycerophospholipid metabolic process#GO:0006650;phospholipid dephosphorylation#GO:0046839;phosphate-containing compound metabolic process#GO:0006796;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238 membrane#GO:0016020;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 phosphatase#PC00181 HUMAN|HGNC=8242|UniProtKB=O95371 O95371 OR2C1 PTHR26453:SF237 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2C1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;nervous system process#GO:0050877;sensory perception#GO:0007600;system process#GO:0003008;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;detection of chemical stimulus#GO:0009593;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;response to chemical#GO:0042221;response to stimulus#GO:0050896 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=18318|UniProtKB=Q8IXJ9 Q8IXJ9 ASXL1 PTHR13578:SF19 ADDITIONAL SEX COMBS LIKE PROTEIN ASXL POLYCOMB GROUP PROTEIN ASXL1 binding#GO:0005488;signaling receptor binding#GO:0005102;chromatin binding#GO:0003682;protein binding#GO:0005515 positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;animal organ development#GO:0048513;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of transcription by RNA polymerase II#GO:0045944;developmental process#GO:0032502;animal organ morphogenesis#GO:0009887;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;animal gross anatomical part developmental process#GO:0160108 intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;PcG protein complex#GO:0031519;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=4296|UniProtKB=P06280 P06280 GLA PTHR11452:SF14 ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE ALPHA-GALACTOSIDASE A hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;catalytic activity#GO:0003824;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553 catabolic process#GO:0009056;carbohydrate derivative catabolic process#GO:1901136;carbohydrate metabolic process#GO:0005975;glycosyl compound catabolic process#GO:1901658;primary metabolic process#GO:0044238;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;oligosaccharide metabolic process#GO:0009311;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 galactosidase#PC00104;hydrolase#PC00121 HUMAN|HGNC=14409|UniProtKB=Q9HC21 Q9HC21 SLC25A19 PTHR24089:SF59 SOLUTE CARRIER FAMILY 25 MITOCHONDRIAL THIAMINE PYROPHOSPHATE CARRIER organophosphate ester transmembrane transporter activity#GO:0015605;quaternary ammonium group transmembrane transporter activity#GO:0015651;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;transport#GO:0006810;organophosphate ester transport#GO:0015748;vitamin transport#GO:0051180;cellular process#GO:0009987;quaternary ammonium group transport#GO:0015697;nitrogen compound transport#GO:0071705 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 secondary carrier transporter#PC00258;mitochondrial carrier protein#PC00158 HUMAN|HGNC=17090|UniProtKB=Q6ZSZ5 Q6ZSZ5 ARHGEF18 PTHR13944:SF23 AGAP007712-PA RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 18 molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;guanyl-nucleotide exchange factor activity#GO:0005085 signal transduction#GO:0007165;cellular process#GO:0009987;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;intracellular signaling cassette#GO:0141124;regulation of response to stimulus#GO:0048583;regulation of small GTPase mediated signal transduction#GO:0051056;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of Rho protein signal transduction#GO:0035023;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of cell communication#GO:0010646;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=14341|UniProtKB=Q8WWZ3 Q8WWZ3 EDARADD PTHR28469:SF1 ECTODYSPLASIN-A RECEPTOR-ASSOCIATED ADAPTER PROTEIN ECTODYSPLASIN-A RECEPTOR-ASSOCIATED ADAPTER PROTEIN molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of non-canonical NF-kappaB signal transduction#GO:1901224;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of signaling#GO:0023056;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of non-canonical NF-kappaB signal transduction#GO:1901222;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789 scaffold/adaptor protein#PC00226 HUMAN|HGNC=17280|UniProtKB=Q9Y2G4 Q9Y2G4 ANKRD6 PTHR24203:SF84 ANKYRIN REPEAT FAMILY PROTEIN ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 6 regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;establishment or maintenance of cell polarity#GO:0007163;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of Wnt signaling pathway#GO:0030111;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular process#GO:0009987 Wnt signaling pathway#P00057>Diversin#P01466 HUMAN|HGNC=7325|UniProtKB=P43246 P43246 MSH2 PTHR11361:SF156 DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER DNA MISMATCH REPAIR PROTEIN MSH2 catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on DNA#GO:0140097;molecular sensor activity#GO:0140299;molecular function regulator activity#GO:0098772;binding#GO:0005488;nucleic acid binding#GO:0003676;ATP-dependent activity#GO:0140657;DNA binding#GO:0003677;ATP-dependent activity, acting on DNA#GO:0008094;double-stranded DNA binding#GO:0003690 multicellular organismal process#GO:0032501;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;adaptive immune response#GO:0002250;somatic cell DNA recombination#GO:0016444;immune response#GO:0006955;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;DNA repair#GO:0006281;developmental process#GO:0032502;DNA damage response#GO:0006974;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular response to stimulus#GO:0051716;somatic diversification of immune receptors#GO:0002200;anatomical structure development#GO:0048856;system development#GO:0048731;mitotic recombination#GO:0006312;gene expression#GO:0010467;response to stress#GO:0006950;cellular process#GO:0009987;somatic recombination of immunoglobulin gene segments#GO:0016447;multicellular organism development#GO:0007275;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;DNA recombination#GO:0006310;immune effector process#GO:0002252;response to stimulus#GO:0050896;production of molecular mediator of immune response#GO:0002440;mismatch repair#GO:0006298;immune system development#GO:0002520;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449;immunoglobulin mediated immune response#GO:0016064;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immune system process#GO:0002376;animal gross anatomical part developmental process#GO:0160108;somatic diversification of immune receptors via germline recombination within a single locus#GO:0002562;cellular response to stress#GO:0033554 organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 DNA metabolism protein#PC00009 HUMAN|HGNC=16111|UniProtKB=O94964 O94964 MTCL2 PTHR15742:SF1 GIRDIN MICROTUBULE CROSS-LINKING FACTOR 2 tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;microtubule binding#GO:0008017;protein binding#GO:0005515 regulation of cellular process#GO:0050794;regulation of catabolic process#GO:0009894;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of autophagy#GO:0010506;regulation of biological process#GO:0050789 microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;supramolecular complex#GO:0099080;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;microtubule#GO:0005874 HUMAN|HGNC=9325|UniProtKB=P50897 P50897 PPT1 PTHR11247:SF81 PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1 PALMITOYL-PROTEIN THIOESTERASE 1 catalytic activity#GO:0003824;thiolester hydrolase activity#GO:0016790;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;palmitoyl hydrolase activity#GO:0098599 multicellular organismal process#GO:0032501;endocytosis#GO:0006897;nervous system development#GO:0007399;import into cell#GO:0098657;anatomical structure development#GO:0048856;establishment of localization#GO:0051234;localization#GO:0051179;multicellular organism development#GO:0007275;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;transport#GO:0006810;developmental process#GO:0032502 protein modifying enzyme#PC00260 HUMAN|HGNC=25523|UniProtKB=Q3V6T2 Q3V6T2 CCDC88A PTHR18947:SF30 HOOK PROTEINS GIRDIN protein binding#GO:0005515;binding#GO:0005488;microtubule binding#GO:0008017;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092 cytoskeleton organization#GO:0007010;cytoskeleton-dependent intracellular transport#GO:0030705;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle organization#GO:0006996;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;transport#GO:0006810;intracellular transport#GO:0046907;cytoplasmic microtubule organization#GO:0031122;cellular component organization#GO:0016043;supramolecular fiber organization#GO:0097435;localization#GO:0051179;cellular localization#GO:0051641;microtubule cytoskeleton organization#GO:0000226 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;microtubule organizing center#GO:0005815;centrosome#GO:0005813;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 membrane traffic protein#PC00150 HUMAN|HGNC=30000|UniProtKB=Q3SYG4 Q3SYG4 BBS9 PTHR20991:SF0 PARATHYROID HORMONE-RESPONSIVE B1 GENE PROTEIN PTHB1 organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031;cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782;cellular component organization#GO:0016043;cilium assembly#GO:0060271;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component assembly#GO:0022607;cell projection organization#GO:0030030;plasma membrane bounded cell projection organization#GO:0120036 cilium#GO:0005929;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;BBSome#GO:0034464;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995 HUMAN|HGNC=28142|UniProtKB=Q9BT23 Q9BT23 LIMD2 PTHR24206:SF103 OS06G0237300 PROTEIN LIM DOMAIN-CONTAINING PROTEIN 2 actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;actin filament binding#GO:0051015;binding#GO:0005488;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 cellular component organization or biogenesis#GO:0071840;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;actin filament-based process#GO:0030029;actin cytoskeleton organization#GO:0030036;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;actin filament bundle organization#GO:0061572;actin filament bundle assembly#GO:0051017 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cell periphery#GO:0071944;membrane#GO:0016020;actin cytoskeleton#GO:0015629 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=15998|UniProtKB=Q8IVL0 Q8IVL0 NAV3 PTHR12784:SF18 STEERIN NEURON NAVIGATOR 3 developmental process#GO:0032502;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;nervous system development#GO:0007399;multicellular organism development#GO:0007275;multicellular organismal process#GO:0032501;anatomical structure development#GO:0048856 microtubule end#GO:1990752;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;supramolecular complex#GO:0099080;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;microtubule#GO:0005874 HUMAN|HGNC=9584|UniProtKB=P59533 P59533 TAS2R38 PTHR11394:SF52 TASTE RECEPTOR TYPE 2 TASTE RECEPTOR TYPE 2 MEMBER 38 signaling receptor activity#GO:0038023;taste receptor activity#GO:0008527;bitter taste receptor activity#GO:0033038;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;detection of chemical stimulus#GO:0009593;sensory perception of bitter taste#GO:0050913;multicellular organismal process#GO:0032501;response to chemical#GO:0042221;response to stimulus#GO:0050896;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of taste#GO:0050909;nervous system process#GO:0050877;detection of chemical stimulus involved in sensory perception of taste#GO:0050912;sensory perception#GO:0007600;detection of chemical stimulus involved in sensory perception of bitter taste#GO:0001580;system process#GO:0003008 cellular anatomical structure#GO:0110165;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=12939|UniProtKB=Q13106 Q13106 ZNF154 PTHR24377:SF934 IP01015P-RELATED ZINC FINGER PROTEIN 154 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=26222|UniProtKB=Q8WVX9 Q8WVX9 FAR1 PTHR11011:SF119 MALE STERILITY PROTEIN 2-RELATED FATTY ACYL-COA REDUCTASE 1 catalytic activity#GO:0003824;oxidoreductase activity, acting on the aldehyde or oxo group of donors#GO:0016903;oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor#GO:0016620;oxidoreductase activity#GO:0016491 purine-containing compound metabolic process#GO:0072521;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;sulfur compound metabolic process#GO:0006790;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;nucleobase-containing compound metabolic process#GO:0006139;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;acyl-CoA metabolic process#GO:0006637;nucleobase-containing small molecule metabolic process#GO:0055086 intracellular organelle#GO:0043229;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;microbody#GO:0042579;membrane#GO:0016020;peroxisome#GO:0005777;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;peroxisomal membrane#GO:0005778;organelle#GO:0043226 HUMAN|HGNC=1591|UniProtKB=P41002 P41002 CCNF PTHR10177:SF496 CYCLINS CYCLIN-F cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538;enzyme regulator activity#GO:0030234;cyclin-dependent protein kinase regulator activity#GO:0019914;protein kinase regulator activity#GO:0019887;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207 mitotic cell cycle#GO:0000278;cell cycle phase transition#GO:0044770;cell cycle G1/S phase transition#GO:0044843;cell cycle process#GO:0022402;cellular process#GO:0009987;cell cycle#GO:0007049;mitotic cell cycle process#GO:1903047;mitotic cell cycle phase transition#GO:0044772;G1/S transition of mitotic cell cycle#GO:0000082 cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;transferase complex#GO:1990234;membraneless organelle#GO:0043228;protein kinase complex#GO:1902911;microtubule cytoskeleton#GO:0015630;nucleus#GO:0005634;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;intracellular membraneless organelle#GO:0043232;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 kinase activator#PC00138 HUMAN|HGNC=23316|UniProtKB=O14756 O14756 HSD17B6 PTHR43313:SF4 SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C 17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 6 oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;alcohol dehydrogenase (NAD+) activity#GO:0004022;oxidoreductase activity#GO:0016491;all-trans-retinol dehydrogenase (NAD+) activity#GO:0004745;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;catalytic activity#GO:0003824 cellular process#GO:0009987;biological regulation#GO:0065007;hormone metabolic process#GO:0042445;lipid metabolic process#GO:0006629;alcohol metabolic process#GO:0006066;metabolic process#GO:0008152;diterpenoid metabolic process#GO:0016101;retinoid metabolic process#GO:0001523;regulation of hormone levels#GO:0010817;primary metabolic process#GO:0044238;small molecule metabolic process#GO:0044281;terpenoid metabolic process#GO:0006721;retinol metabolic process#GO:0042572;olefinic compound metabolic process#GO:0120254;regulation of biological quality#GO:0065008;isoprenoid metabolic process#GO:0006720 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 Androgen/estrogene/progesterone biosynthesis#P02727>Estradiol 17beta-dehydrogenase#P02826 HUMAN|HGNC=14902|UniProtKB=Q9NRW1 Q9NRW1 RAB6B PTHR24073:SF343 DRAB5-RELATED RAS-RELATED PROTEIN RAB-6B hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817 cytosolic transport#GO:0016482;protein localization to organelle#GO:0033365;intra-Golgi vesicle-mediated transport#GO:0006891;protein localization to membrane#GO:0072657;protein transport#GO:0015031;localization#GO:0051179;cellular localization#GO:0051641;localization within membrane#GO:0051668;vesicle-mediated transport#GO:0016192;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;cellular process#GO:0009987;macromolecule localization#GO:0033036;retrograde transport, endosome to Golgi#GO:0042147;intracellular protein localization#GO:0008104;endosomal transport#GO:0016197;establishment of localization#GO:0051234;transport#GO:0006810;intracellular protein transport#GO:0006886;Golgi vesicle transport#GO:0048193;protein localization to Golgi apparatus#GO:0034067;intracellular transport#GO:0046907 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226 G-protein#PC00020;small GTPase#PC00208 HUMAN|HGNC=25554|UniProtKB=Q96CQ1 Q96CQ1 SLC25A36 PTHR45829:SF2 MITOCHONDRIAL CARRIER PROTEIN RIM2 SOLUTE CARRIER FAMILY 25 MEMBER 36 nucleobase-containing compound transmembrane transporter activity#GO:0015932;organophosphate ester transmembrane transporter activity#GO:0015605;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;transport#GO:0006810;organophosphate ester transport#GO:0015748;nucleobase-containing compound transport#GO:0015931;nitrogen compound transport#GO:0071705;cellular process#GO:0009987 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 secondary carrier transporter#PC00258;mitochondrial carrier protein#PC00158 HUMAN|HGNC=3273|UniProtKB=O15372 O15372 EIF3H PTHR10410:SF3 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT H deubiquitinase activity#GO:0101005;metallopeptidase activity#GO:0008237;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;translation factor activity#GO:0180051;catalytic activity, acting on a protein#GO:0140096;translation initiation factor activity#GO:0003743;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233 translation#GO:0006412;translational initiation#GO:0006413;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein biosynthetic process#GO:0160307 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;eukaryotic translation initiation factor 3 complex#GO:0005852;ribonucleoprotein complex#GO:1990904 translation factor#PC00223;translation initiation factor#PC00224 HUMAN|HGNC=5756|UniProtKB=P04432 P04432 IGKV1D-39 PTHR23267:SF402 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN KAPPA VARIABLE 1-39-RELATED response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 protein-containing complex#GO:0032991 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=6264|UniProtKB=P48549 P48549 KCNJ3 PTHR11767:SF16 INWARD RECTIFIER POTASSIUM CHANNEL G PROTEIN-ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1 voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;transporter activity#GO:0005215;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;potassium channel activity#GO:0005267;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation channel activity#GO:0005261;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857 monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;import across plasma membrane#GO:0098739;metal ion transport#GO:0030001;inorganic ion import across plasma membrane#GO:0099587;potassium ion import across plasma membrane#GO:1990573;import into cell#GO:0098657;establishment of localization#GO:0051234;inorganic cation import across plasma membrane#GO:0098659;transport#GO:0006810;potassium ion transport#GO:0006813;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 ion channel#PC00133 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GIRK#P00724;GABA-B receptor II signaling#P05731>K channel#P05758;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GPRK#P00741;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>GIRK#P01083 HUMAN|HGNC=34032|UniProtKB=Q3KNS6 Q3KNS6 ZNF829 PTHR23226:SF436 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER PROTEIN 829 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=8818|UniProtKB=O43511 O43511 SLC26A4 PTHR11814:SF33 SULFATE TRANSPORTER PENDRIN chloride transmembrane transporter activity#GO:0015108;antiporter activity#GO:0015297;bicarbonate transmembrane transporter activity#GO:0015106;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic anion transmembrane transporter activity#GO:0008509;secondary active transmembrane transporter activity#GO:0015291;monoatomic ion transmembrane transporter activity#GO:0015075;dicarboxylic acid transmembrane transporter activity#GO:0005310;active transmembrane transporter activity#GO:0022804;carboxylic acid transmembrane transporter activity#GO:0046943 monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220;monoatomic anion transport#GO:0006820;cellular process#GO:0009987;localization#GO:0051179;chloride transmembrane transport#GO:1902476;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;inorganic anion transport#GO:0015698;monoatomic ion transport#GO:0006811;chloride transport#GO:0006821;transport#GO:0006810 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227 HUMAN|HGNC=14177|UniProtKB=Q6PII5 Q6PII5 HAGHL PTHR11935:SF77 BETA LACTAMASE DOMAIN HYDROXYACYLGLUTATHIONE HYDROLASE-LIKE PROTEIN hydrolase activity, acting on ester bonds#GO:0016788;thiolester hydrolase activity#GO:0016790;catalytic activity#GO:0003824;hydrolase activity#GO:0016787 HUMAN|HGNC=11496|UniProtKB=O14994 O14994 SYN3 PTHR10841:SF6 SYNAPSIN SYNAPSIN-3 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;cytoskeletal adaptor activity#GO:0008093 vesicle-mediated transport#GO:0016192;synaptic vesicle localization#GO:0097479;vesicle localization#GO:0051648;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;vesicle-mediated transport in synapse#GO:0099003;establishment of localization#GO:0051234;synaptic vesicle cycle#GO:0099504;transport#GO:0006810;cell junction organization#GO:0034330;cellular component organization#GO:0016043;localization#GO:0051179;cellular localization#GO:0051641;organelle localization#GO:0051640;synapse organization#GO:0050808 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;organelle#GO:0043226;cellular anatomical structure#GO:0110165;synapse#GO:0045202;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;synaptic vesicle membrane#GO:0030672;vesicle#GO:0031982;synaptic vesicle#GO:0008021;cell junction#GO:0030054;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;transport vesicle#GO:0030133;endomembrane system#GO:0012505;transport vesicle membrane#GO:0030658;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;vesicle membrane#GO:0012506;secretory vesicle#GO:0099503;membrane#GO:0016020;presynapse#GO:0098793 membrane trafficking regulatory protein#PC00151;membrane traffic protein#PC00150 HUMAN|HGNC=25257|UniProtKB=Q96B42 Q96B42 TMEM18 PTHR22593:SF2 TRANSMEMBRANE PROTEIN 18 TRANSMEMBRANE PROTEIN 18 nucleus#GO:0005634;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;nuclear membrane#GO:0031965 HUMAN|HGNC=29347|UniProtKB=Q96M94 Q96M94 KLHL15 PTHR45632:SF12 LD33804P KELCH-LIKE PROTEIN 15 ubiquitin-like ligase-substrate adaptor activity#GO:1990756;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;enzyme-substrate adaptor activity#GO:0140767 cellular response to stimulus#GO:0051716;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;negative regulation of DNA recombination#GO:0045910;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;protein quality control for misfolded or incompletely synthesized proteins#GO:0006515;cellular response to topologically incorrect protein#GO:0035967;regulation of double-strand break repair#GO:2000779;protein metabolic process#GO:0019538;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of DNA metabolic process#GO:0051053;biological regulation#GO:0065007;negative regulation of response to stimulus#GO:0048585;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of response to stimulus#GO:0048583;regulation of DNA repair#GO:0006282;cellular response to misfolded protein#GO:0071218;regulation of response to stress#GO:0080134;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;negative regulation of cellular process#GO:0048523;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;regulation of DNA metabolic process#GO:0051052;regulation of biological process#GO:0050789;response to misfolded protein#GO:0051788;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;response to topologically incorrect protein#GO:0035966;response to stimulus#GO:0050896;regulation of double-strand break repair via homologous recombination#GO:0010569;modification-dependent macromolecule catabolic process#GO:0043632;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;regulation of DNA recombination#GO:0000018;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of cellular response to stress#GO:0080135;cellular process#GO:0009987;response to stress#GO:0006950;proteasomal protein catabolic process#GO:0010498;negative regulation of double-strand break repair via homologous recombination#GO:2000042;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152 ubiquitin ligase complex#GO:0000151;Cul3-RING ubiquitin ligase complex#GO:0031463;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227;transferase complex#GO:1990234;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cullin-RING ubiquitin ligase complex#GO:0031461;nucleus#GO:0005634 scaffold/adaptor protein#PC00226 HUMAN|HGNC=11104|UniProtKB=Q92922 Q92922 SMARCC1 PTHR12802:SF9 SWI/SNF COMPLEX-RELATED SWI_SNF COMPLEX SUBUNIT SMARCC1 histone binding#GO:0042393;binding#GO:0005488;protein binding#GO:0005515 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of DNA-templated transcription#GO:0006355;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789 chromatin#GO:0000785;nucleus#GO:0005634;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;SWI/SNF superfamily-type complex#GO:0070603;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;ATPase complex#GO:1904949;SWI/SNF complex#GO:0016514;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 chromatin/chromatin-binding, or -regulatory protein#PC00077 Wnt signaling pathway#P00057>SWI/SNF#P01435 HUMAN|HGNC=11916|UniProtKB=P19438 P19438 TNFRSF1A PTHR46861:SF1 TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 1A TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 1A molecular transducer activity#GO:0060089;protein binding#GO:0005515;tumor necrosis factor binding#GO:0043120;death receptor activity#GO:0005035;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888;cytokine binding#GO:0019955;signaling receptor activity#GO:0038023 response to stimulus#GO:0050896;defense response#GO:0006952;response to stress#GO:0006950;inflammatory response#GO:0006954 membrane raft#GO:0045121;membrane#GO:0016020;signaling receptor complex#GO:0043235;membrane microdomain#GO:0098857;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 transmembrane signal receptor#PC00197 Apoptosis signaling pathway#P00006>TNFR1#P00288 HUMAN|HGNC=25948|UniProtKB=Q7Z4H7 Q7Z4H7 HAUS6 PTHR16151:SF2 HAUS AUGMIN-LIKE COMPLEX SUBUNIT 6 HAUS AUGMIN-LIKE COMPLEX SUBUNIT 6 microtubule binding#GO:0008017;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;protein binding#GO:0005515 cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;cytoskeleton organization#GO:0007010;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;spindle microtubule#GO:0005876;microtubule#GO:0005874;mitotic spindle#GO:0072686;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoskeleton#GO:0005856;spindle#GO:0005819;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080 HUMAN|HGNC=15141|UniProtKB=Q8NGQ3 Q8NGQ3 OR1S2 PTHR48001:SF115 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 1S1-RELATED transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell communication#GO:0007154;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=32951|UniProtKB=Q5DT21 Q5DT21 SPINK9 PTHR47499:SF2 SERINE PROTEASE INHIBITOR KAZAL-TYPE 7 SPINK7 SERINE PROTEASE INHIBITOR KAZAL-TYPE 9 endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772;enzyme inhibitor activity#GO:0004857;enzyme regulator activity#GO:0030234;serine-type endopeptidase inhibitor activity#GO:0004867;molecular function inhibitor activity#GO:0140678;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414;peptidase regulator activity#GO:0061134 regulation of biological process#GO:0050789;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;regulation of primary metabolic process#GO:0080090;negative regulation of biological process#GO:0048519;negative regulation of protein metabolic process#GO:0051248;biological regulation#GO:0065007;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of proteolysis#GO:0030162;negative regulation of cellular process#GO:0048523 protein-binding activity modulator#PC00095;protease inhibitor#PC00191 HUMAN|HGNC=13194|UniProtKB=O43264 O43264 ZW10 PTHR12205:SF0 CENTROMERE/KINETOCHORE PROTEIN ZW10 CENTROMERE_KINETOCHORE PROTEIN ZW10 HOMOLOG regulation of mitotic sister chromatid segregation#GO:0033047;negative regulation of mitotic metaphase/anaphase transition#GO:0045841;cellular response to stimulus#GO:0051716;negative regulation of organelle organization#GO:0010639;cell cycle#GO:0007049;regulation of cell cycle phase transition#GO:1901987;regulation of cellular process#GO:0050794;transport#GO:0006810;negative regulation of cellular process#GO:0048523;intracellular transport#GO:0046907;chromosome organization#GO:0051276;mitotic cell cycle process#GO:1903047;negative regulation of chromosome separation#GO:1905819;biological regulation#GO:0065007;regulation of mitotic metaphase/anaphase transition#GO:0030071;nuclear division#GO:0000280;cellular localization#GO:0051641;regulation of organelle organization#GO:0033043;cell cycle process#GO:0022402;mitotic nuclear division#GO:0140014;regulation of biological process#GO:0050789;negative regulation of mitotic nuclear division#GO:0045839;negative regulation of cell cycle phase transition#GO:1901988;nuclear chromosome segregation#GO:0098813;sister chromatid segregation#GO:0000819;negative regulation of biological process#GO:0048519;regulation of cell cycle#GO:0051726;response to stimulus#GO:0050896;regulation of cellular component organization#GO:0051128;negative regulation of mitotic sister chromatid segregation#GO:0033048;negative regulation of metaphase/anaphase transition of cell cycle#GO:1902100;negative regulation of chromosome segregation#GO:0051985;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;signal transduction#GO:0007165;establishment of localization in cell#GO:0051649;negative regulation of sister chromatid segregation#GO:0033046;organelle organization#GO:0006996;vesicle-mediated transport#GO:0016192;regulation of chromosome separation#GO:1905818;negative regulation of mitotic cell cycle phase transition#GO:1901991;negative regulation of chromosome organization#GO:2001251;intracellular signal transduction#GO:0035556;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;organelle fission#GO:0048285;localization#GO:0051179;cell communication#GO:0007154;negative regulation of cellular component organization#GO:0051129;mitotic cell cycle checkpoint signaling#GO:0007093;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;mitotic cell cycle#GO:0000278;negative regulation of cell cycle process#GO:0010948;regulation of chromosome organization#GO:0033044;regulation of mitotic nuclear division#GO:0007088;establishment of localization#GO:0051234;regulation of mitotic sister chromatid separation#GO:0010965;regulation of mitotic cell cycle#GO:0007346;mitotic sister chromatid segregation#GO:0000070;negative regulation of nuclear division#GO:0051784;regulation of nuclear division#GO:0051783;negative regulation of mitotic sister chromatid separation#GO:2000816;negative regulation of mitotic cell cycle#GO:0045930;regulation of mitotic cell cycle phase transition#GO:1901990;cellular component organization#GO:0016043;regulation of sister chromatid segregation#GO:0033045;signaling#GO:0023052;Golgi vesicle transport#GO:0048193;regulation of chromosome segregation#GO:0051983;chromosome segregation#GO:0007059;negative regulation of cell cycle#GO:0045786;mitotic spindle assembly checkpoint signaling#GO:0007094;regulation of cell cycle process#GO:0010564;cell cycle checkpoint signaling#GO:0000075 intracellular organelle#GO:0043229;spindle microtubule#GO:0005876;microtubule#GO:0005874;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membrane-bounded organelle#GO:0043227;chromosome#GO:0005694;kinetochore#GO:0000776;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;condensed chromosome#GO:0000793;cytoskeleton#GO:0005856;chromosome, centromeric region#GO:0000775;spindle#GO:0005819;endoplasmic reticulum#GO:0005783;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;vesicle tethering complex#GO:0099023;endoplasmic reticulum protein-containing complex#GO:0140534;condensed chromosome, centromeric region#GO:0000779;microtubule cytoskeleton#GO:0015630;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232 microtubule or microtubule-binding cytoskeletal protein#PC00157;cytoskeletal protein#PC00085 HUMAN|HGNC=14841|UniProtKB=Q8NH85 Q8NH85 OR8U3 PTHR48018:SF109 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 8U3 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;signal transduction#GO:0007165;cellular process#GO:0009987;cell communication#GO:0007154;sensory perception#GO:0007600;nervous system process#GO:0050877;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;sensory perception of smell#GO:0007608;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=32554|UniProtKB=A6ND36 A6ND36 FAM83G PTHR16181:SF39 PROTEIN FAM83A-RELATED PROTEIN FAM83G protein kinase binding#GO:0019901;enzyme binding#GO:0019899;binding#GO:0005488;kinase binding#GO:0019900;protein binding#GO:0005515 response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;BMP signaling pathway#GO:0030509;cellular response to stimulus#GO:0051716;response to growth factor#GO:0070848;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;regulation of cellular process#GO:0050794;signaling#GO:0023052;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;cellular response to growth factor stimulus#GO:0071363;signal transduction#GO:0007165;cellular process#GO:0009987;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;biological regulation#GO:0065007;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;cellular response to BMP stimulus#GO:0071773;response to BMP#GO:0071772;cell surface receptor signaling pathway#GO:0007166 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=4313|UniProtKB=P23378 P23378 GLDC PTHR11773:SF1 GLYCINE DEHYDROGENASE, DECARBOXYLATING GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;proteinogenic amino acid metabolic process#GO:0170039;amino acid metabolic process#GO:0006520;small molecule catabolic process#GO:0044282;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cytosol#GO:0005829;mitochondrion#GO:0005739 oxidoreductase#PC00176;dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=32789|UniProtKB=Q6UXV0 Q6UXV0 GFRAL PTHR10269:SF1 GDNF RECEPTOR ALPHA GDNF FAMILY RECEPTOR ALPHA-LIKE signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 multicellular organism development#GO:0007275;multicellular organismal process#GO:0032501;anatomical structure development#GO:0048856;system development#GO:0048731;nervous system development#GO:0007399;animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502 external side of plasma membrane#GO:0009897;signaling receptor complex#GO:0043235;side of membrane#GO:0098552;membrane#GO:0016020;cell periphery#GO:0071944;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=30925|UniProtKB=Q3LIE5 Q3LIE5 ADPRM PTHR16509:SF1 FAMILY NOT NAMED MANGANESE-DEPENDENT ADP-RIBOSE_CDP-ALCOHOL DIPHOSPHATASE cation binding#GO:0043169;metal ion binding#GO:0046872;hydrolase activity#GO:0016787;transition metal ion binding#GO:0046914;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;small molecule binding#GO:0036094;ion binding#GO:0043167;cyclic-nucleotide phosphodiesterase activity#GO:0004112;phosphoric ester hydrolase activity#GO:0042578;phosphoric diester hydrolase activity#GO:0008081;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462 HUMAN|HGNC=4746|UniProtKB=P62807 P62807 H2BC4 PTHR23428:SF385 HISTONE H2B HISTONE H2B TYPE 1-C_E_F_G_I defense response to other organism#GO:0098542;response to other organism#GO:0051707;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;defense response to symbiont#GO:0140546;immune response#GO:0006955;antibacterial humoral response#GO:0019731;innate immune response#GO:0045087;defense response#GO:0006952;response to external stimulus#GO:0009605;humoral immune response#GO:0006959;antimicrobial humoral response#GO:0019730;response to stimulus#GO:0050896;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;immune system process#GO:0002376;response to bacterium#GO:0009617;defense response to bacterium#GO:0042742 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=19277|UniProtKB=Q8TDE3 Q8TDE3 RNASE8 PTHR11437:SF25 RIBONUCLEASE RIBONUCLEASE 8 catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;RNA nuclease activity#GO:0004540;nuclease activity#GO:0004518;catalytic activity, acting on RNA#GO:0140098 response to stress#GO:0006950;response to biotic stimulus#GO:0009607;immune response#GO:0006955;defense response to symbiont#GO:0140546;defense response to other organism#GO:0098542;response to other organism#GO:0051707;innate immune response#GO:0045087;defense response#GO:0006952;response to external stimulus#GO:0009605;defense response to Gram-positive bacterium#GO:0050830;response to stimulus#GO:0050896;defense response to fungus#GO:0050832;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;defense response to Gram-negative bacterium#GO:0050829;immune system process#GO:0002376;response to bacterium#GO:0009617;defense response to bacterium#GO:0042742 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 endoribonuclease#PC00094;RNA metabolism protein#PC00031 HUMAN|HGNC=12420|UniProtKB=P49411 P49411 TUFM PTHR43721:SF36 ELONGATION FACTOR TU-RELATED ELONGATION FACTOR TU, MITOCHONDRIAL translation factor activity#GO:0180051;translation elongation factor activity#GO:0003746 mitochondrial gene expression#GO:0140053;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;translation#GO:0006412;translational elongation#GO:0006414;metabolic process#GO:0008152;biosynthetic process#GO:0009058;mitochondrial translation#GO:0032543;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 translation elongation factor#PC00222 HUMAN|HGNC=28659|UniProtKB=Q6UWN0 Q6UWN0 LYPD4 PTHR16529:SF6 CD177 ANTIGEN LY6_PLAUR DOMAIN-CONTAINING PROTEIN 4 cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;plasma membrane#GO:0005886;membrane#GO:0016020;membrane raft#GO:0045121;cell periphery#GO:0071944;plasma membrane raft#GO:0044853;membrane microdomain#GO:0098857 HUMAN|HGNC=37134|UniProtKB=A8MUZ8 A8MUZ8 ZNF705G PTHR24381:SF19 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 705G-RELATED transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=2663|UniProtKB=Q9UI36 Q9UI36 DACH1 PTHR12577:SF14 DACHSHUND DACHSHUND HOMOLOG 1 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;winged helix/forkhead transcription factor#PC00246 HUMAN|HGNC=19239|UniProtKB=Q9BT88 Q9BT88 SYT11 PTHR10024:SF115 SYNAPTOTAGMIN SYNAPTOTAGMIN-11 SNARE binding#GO:0000149;binding#GO:0005488;phospholipid binding#GO:0005543;protein binding#GO:0005515;molecular function regulator activity#GO:0098772;lipid binding#GO:0008289;molecular sensor activity#GO:0140299 cellular process#GO:0009987;positive regulation of transport#GO:0051050;establishment of localization in cell#GO:0051649;positive regulation of biological process#GO:0048518;synaptic vesicle exocytosis#GO:0016079;synaptic signaling#GO:0099536;organelle organization#GO:0006996;organelle membrane fusion#GO:0090174;neurotransmitter transport#GO:0006836;vesicle-mediated transport#GO:0016192;organelle fusion#GO:0048284;regulated exocytosis#GO:0045055;vesicle organization#GO:0016050;positive regulation of vesicle fusion#GO:0031340;exocytosis#GO:0006887;regulation of localization#GO:0032879;regulation of transport#GO:0051049;vesicle-mediated transport in synapse#GO:0099003;cellular component organization or biogenesis#GO:0071840;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;cellular component organization#GO:0016043;signaling#GO:0023052;export from cell#GO:0140352;regulation of cellular component organization#GO:0051128;positive regulation of cellular component organization#GO:0051130;regulation of secretion by cell#GO:1903530;secretion by cell#GO:0032940;positive regulation of organelle organization#GO:0010638;cellular localization#GO:0051641;positive regulation of cellular process#GO:0048522;membrane fusion#GO:0061025;neurotransmitter secretion#GO:0007269;cell-cell signaling#GO:0007267;membrane organization#GO:0061024;biological regulation#GO:0065007;synaptic vesicle cycle#GO:0099504;transport#GO:0006810;establishment of localization#GO:0051234;chemical synaptic transmission#GO:0007268;signal release from synapse#GO:0099643;vesicle fusion#GO:0006906;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;trans-synaptic signaling#GO:0099537;signal release#GO:0023061;regulation of exocytosis#GO:0017157;secretion#GO:0046903;localization#GO:0051179;cell communication#GO:0007154;regulation of secretion#GO:0051046 secretory vesicle#GO:0099503;membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005;endomembrane system#GO:0012505;transport vesicle#GO:0030133;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cell junction#GO:0030054;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;cell projection#GO:0042995;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;axon#GO:0030424;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227 membrane trafficking regulatory protein#PC00151 Synaptic vesicle trafficking#P05734>Synaptotagmin#P05769 HUMAN|HGNC=5949|UniProtKB=Q93033 Q93033 CD101 PTHR12207:SF25 V-SET AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN IMMUNOGLOBULIN SUPERFAMILY MEMBER 2 membrane#GO:0016020;cellular anatomical structure#GO:0110165 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=11858|UniProtKB=O43657 O43657 TSPAN6 PTHR19282:SF169 TETRASPANIN TETRASPANIN-6 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=21701|UniProtKB=Q6PJG6 Q6PJG6 BRAT1 PTHR21331:SF2 BRCA1-ASSOCIATED ATM ACTIVATOR 1 INTEGRATOR COMPLEX ASSEMBLY FACTOR BRAT1 response to stimulus#GO:0050896;response to stress#GO:0006950;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;DNA damage response#GO:0006974;cellular response to stress#GO:0033554 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=1391|UniProtKB=Q01668 Q01668 CACNA1D PTHR45628:SF11 VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1 VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;transporter activity#GO:0005215;voltage-gated channel activity#GO:0022832;calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;monoatomic cation channel activity#GO:0005261;passive transmembrane transporter activity#GO:0022803;calcium channel activity#GO:0005262;transmembrane transporter activity#GO:0022857;voltage-gated calcium channel activity#GO:0005245;channel activity#GO:0015267 import across plasma membrane#GO:0098739;metal ion transport#GO:0030001;inorganic ion import across plasma membrane#GO:0099587;calcium ion transmembrane transport#GO:0070588;calcium ion import#GO:0070509;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987;establishment of localization#GO:0051234;import into cell#GO:0098657;calcium ion transmembrane import into cytosol#GO:0097553;inorganic cation import across plasma membrane#GO:0098659;calcium ion transport#GO:0006816;transport#GO:0006810 cation channel complex#GO:0034703;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;calcium channel complex#GO:0034704;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane protein complex#GO:0098796;membrane#GO:0016020;voltage-gated calcium channel complex#GO:0005891;plasma membrane#GO:0005886;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 voltage-gated ion channel#PC00241 Nicotinic acetylcholine receptor signaling pathway#P00044>Ca2+ channel#P01096;Gonadotropin-releasing hormone receptor pathway#P06664>L-type Ca2+#P06812;Alzheimer disease-amyloid secretase pathway#P00003>L-type calcium channels#P00082;Oxytocin receptor mediated signaling pathway#P04391>Ca2+ channel#P04535;Beta2 adrenergic receptor signaling pathway#P04378>Ca2+ channel#P04445;Beta1 adrenergic receptor signaling pathway#P04377>Ca2+ channel#P04438;5HT2 type receptor mediated signaling pathway#P04374>Ca2+ channel#P04411 HUMAN|HGNC=1072|UniProtKB=P22003 P22003 BMP5 PTHR11848:SF139 TGF-BETA FAMILY BONE MORPHOGENETIC PROTEIN 5 signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;cytokine activity#GO:0005125;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772 cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;cellular response to growth factor stimulus#GO:0071363;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;cellular response to endogenous stimulus#GO:0071495;response to growth factor#GO:0070848;circulatory system development#GO:0072359;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;BMP signaling pathway#GO:0030509;multicellular organism development#GO:0007275;animal organ development#GO:0048513;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;response to BMP#GO:0071772;developmental process#GO:0032502;cellular response to BMP stimulus#GO:0071773;cell surface receptor signaling pathway#GO:0007166;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;heart development#GO:0007507;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;signal transduction#GO:0007165;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 growth factor#PC00112 TGF-beta signaling pathway#P00052>TGFbeta#P01286 HUMAN|HGNC=15041|UniProtKB=Q6IFH4 Q6IFH4 OR6B2 PTHR26452:SF222 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 6B2-RELATED olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 sensory perception of chemical stimulus#GO:0007606;sensory perception#GO:0007600;nervous system process#GO:0050877;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;system process#GO:0003008 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=1374|UniProtKB=P07451 P07451 CA3 PTHR18952:SF127 CARBONIC ANHYDRASE CARBONIC ANHYDRASE 3 catalytic activity#GO:0003824;lyase activity#GO:0016829;carbon-oxygen lyase activity#GO:0016835;hydro-lyase activity#GO:0016836 response to stimulus#GO:0050896;response to chemical#GO:0042221;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to abiotic stimulus#GO:0009628;response to stress#GO:0006950;cellular response to hypoxia#GO:0071456;response to oxygen levels#GO:0070482;response to decreased oxygen levels#GO:0036293;response to hypoxia#GO:0001666;cellular response to stress#GO:0033554;cellular response to chemical stimulus#GO:0070887 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 metabolite interconversion enzyme#PC00262;dehydratase#PC00091 HUMAN|HGNC=29345|UniProtKB=Q9BY89 Q9BY89 KIAA1671 PTHR22042:SF3 TANKYRASE 1 BINDING PROTEIN KIAA1671 HOMOLOG HUMAN|HGNC=11627|UniProtKB=Q12870 Q12870 TCF15 PTHR23349:SF4 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST TRANSCRIPTION FACTOR 15 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=21493|UniProtKB=Q8WXU2 Q8WXU2 DNAAF4 PTHR46492:SF2 DYNEIN ASSEMBLY FACTOR 4, AXONEMAL DYNEIN AXONEMAL ASSEMBLY FACTOR 4 nuclear estrogen receptor binding#GO:0030331;nuclear receptor binding#GO:0016922;binding#GO:0005488;transcription factor binding#GO:0008134;DNA-binding transcription factor binding#GO:0140297;protein binding#GO:0005515;RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629 establishment of localization#GO:0051234;plasma membrane bounded cell projection assembly#GO:0120031;specification of symmetry#GO:0009799;transport#GO:0006810;developmental process#GO:0032502;multicellular organismal process#GO:0032501;regionalization#GO:0003002;plasma membrane bounded cell projection organization#GO:0120036;outer dynein arm assembly#GO:0036158;anatomical structure development#GO:0048856;microtubule cytoskeleton organization#GO:0000226;localization#GO:0051179;axoneme assembly#GO:0035082;system development#GO:0048731;organelle assembly#GO:0070925;microtubule bundle formation#GO:0001578;axonemal dynein complex assembly#GO:0070286;pattern specification process#GO:0007389;microtubule-based movement#GO:0007018;determination of left/right symmetry#GO:0007368;animal organ development#GO:0048513;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;microtubule-based process#GO:0007017;left/right pattern formation#GO:0060972;heart development#GO:0007507;cellular component assembly#GO:0022607;determination of bilateral symmetry#GO:0009855;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cell projection assembly#GO:0030031;cilium organization#GO:0044782;animal gross anatomical part developmental process#GO:0160108;inner dynein arm assembly#GO:0036159;cilium movement#GO:0003341;microtubule-based transport#GO:0099111;cell projection organization#GO:0030030;circulatory system development#GO:0072359;cilium assembly#GO:0060271;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003 chaperone#PC00072 HUMAN|HGNC=16693|UniProtKB=Q16538 Q16538 GPR162 PTHR16518:SF6 G-PROTEIN COUPLED RECEPTOR 153, 162 G PROTEIN-COUPLED RECEPTOR 162-RELATED G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=30931|UniProtKB=Q68CK6 Q68CK6 ACSM2B PTHR43605:SF3 ACYL-COENZYME A SYNTHETASE ACYL-COENZYME A SYNTHETASE ACSM2B, MITOCHONDRIAL acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;ATP-dependent activity#GO:0140657;ligase activity#GO:0016874;acyltransferase activity#GO:0016746;ligase activity, forming carbon-sulfur bonds#GO:0016877;transferase activity#GO:0016740;catalytic activity#GO:0003824 lipid biosynthetic process#GO:0008610;fatty acid biosynthetic process#GO:0006633;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;organophosphate metabolic process#GO:0019637;sulfur compound metabolic process#GO:0006790;cellular process#GO:0009987;monocarboxylic acid biosynthetic process#GO:0072330;acyl-CoA metabolic process#GO:0006637;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;monocarboxylic acid metabolic process#GO:0032787;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;carboxylic acid biosynthetic process#GO:0046394;purine-containing compound metabolic process#GO:0072521;oxoacid metabolic process#GO:0043436 mitochondrion#GO:0005739;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;ligase#PC00142 HUMAN|HGNC=4323|UniProtKB=Q04760 Q04760 GLO1 PTHR10374:SF30 LACTOYLGLUTATHIONE LYASE GLYOXALASE I LACTOYLGLUTATHIONE LYASE metabolite interconversion enzyme#PC00262;lyase#PC00144 HUMAN|HGNC=1673|UniProtKB=P04234 P04234 CD3D PTHR10570:SF5 T-CELL SURFACE GLYCOPROTEIN CD3 GAMMA CHAIN / DELTA CHAIN T-CELL SURFACE GLYCOPROTEIN CD3 DELTA CHAIN transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 anatomical structure development#GO:0048856;cell communication#GO:0007154;immune system process#GO:0002376;cell activation#GO:0001775;lymphocyte differentiation#GO:0030098;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;response to stimulus#GO:0050896;cell development#GO:0048468;signaling#GO:0023052;leukocyte differentiation#GO:0002521;T cell activation#GO:0042110;leukocyte activation#GO:0045321;cellular response to stimulus#GO:0051716;mononuclear cell differentiation#GO:1903131;regulation of biological process#GO:0050789;cellular developmental process#GO:0048869;cell surface receptor signaling pathway#GO:0007166;developmental process#GO:0032502;multicellular organismal process#GO:0032501;lymphocyte activation#GO:0046649;biological regulation#GO:0065007;hemopoiesis#GO:0030097;T cell differentiation#GO:0030217;cellular process#GO:0009987;signal transduction#GO:0007165 side of membrane#GO:0098552;signaling receptor complex#GO:0043235;external side of plasma membrane#GO:0009897;cell surface#GO:0009986;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944 immunoglobulin receptor superfamily#PC00124 T cell activation#P00053>CD3 delta#P01326 HUMAN|HGNC=7958|UniProtKB=Q15761 Q15761 NPY5R PTHR24235:SF10 NEUROPEPTIDE Y RECEPTOR NEUROPEPTIDE Y RECEPTOR TYPE 5 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888;neuropeptide receptor activity#GO:0008188 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;anterograde trans-synaptic signaling#GO:0098916;signaling#GO:0023052;chemical synaptic transmission#GO:0007268;neuropeptide signaling pathway#GO:0007218;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cell communication#GO:0007154;trans-synaptic signaling#GO:0099537;G protein-coupled receptor signaling pathway#GO:0007186;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;synaptic signaling#GO:0099536;cellular process#GO:0009987;signal transduction#GO:0007165 membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005;cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;cell projection#GO:0042995 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=16968|UniProtKB=Q9UBL0 Q9UBL0 ARPP21 PTHR15672:SF14 CAMP-REGULATED PHOSPHOPROTEIN 21 RELATED R3H DOMAIN CONTAINING PROTEIN CAMP-REGULATED PHOSPHOPROTEIN 21 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=15494|UniProtKB=Q9H246 Q9H246 C1orf21 PTHR14974:SF3 SIMILAR TO RIKEN CDNA 1700025G04 GENE SIMILAR TO HUMAN CHROMOSOME 1 OPEN READING FRAME 21 HUMAN|HGNC=14675|UniProtKB=P78412 P78412 IRX6 PTHR11211:SF11 IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX-6 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;cell development#GO:0048468;neuron differentiation#GO:0030182;developmental process#GO:0032502;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;multicellular organism development#GO:0007275;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;nervous system development#GO:0007399;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=10938|UniProtKB=O60779 O60779 SLC19A2 PTHR10686:SF19 FOLATE TRANSPORTER THIAMINE TRANSPORTER 1 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 transport#GO:0006810;cellular process#GO:0009987;nitrogen compound transport#GO:0071705;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;vitamin transport#GO:0051180;localization#GO:0051179 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227 HUMAN|HGNC=28760|UniProtKB=Q9BTT4 Q9BTT4 MED10 PTHR13345:SF13 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 10 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 10 RNA metabolism protein#PC00031;general transcription factor#PC00259 HUMAN|HGNC=6743|UniProtKB=Q14444 Q14444 CAPRIN1 PTHR22922:SF3 GPI-ANCHORED PROTEIN P137 CAPRIN-1 RNA metabolism protein#PC00031 HUMAN|HGNC=32250|UniProtKB=Q658T7 Q658T7 FAM90A2P PTHR16035:SF14 PROTEIN FAM90A1 PROTEIN FAM90A10-RELATED HUMAN|HGNC=16116|UniProtKB=Q9BR26 Q9BR26 OCSTAMP PTHR21041:SF3 DENDRITIC CELL-SPECIFIC TRANSMEMBRANE PROTEIN OSTEOCLAST STIMULATORY TRANSMEMBRANE PROTEIN leukocyte differentiation#GO:0002521;single fertilization#GO:0007338;cellular process#GO:0009987;cell differentiation#GO:0030154;myeloid cell differentiation#GO:0030099;hemopoiesis#GO:0030097;cell development#GO:0048468;fertilization#GO:0009566;reproductive process#GO:0022414;developmental process#GO:0032502;sexual reproduction#GO:0019953;cellular developmental process#GO:0048869;anatomical structure development#GO:0048856;osteoclast differentiation#GO:0030316 HUMAN|HGNC=19036|UniProtKB=O60307 O60307 MAST3 PTHR24356:SF140 SERINE/THREONINE-PROTEIN KINASE MICROTUBULE-ASSOCIATED SERINE_THREONINE-PROTEIN KINASE 3 catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;regulation of cell cycle#GO:0051726;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;regulation of mitotic cell cycle#GO:0007346;signal transduction#GO:0007165;organelle organization#GO:0006996;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=6381|UniProtKB=O15229 O15229 KMO PTHR46028:SF2 KYNURENINE 3-MONOOXYGENASE KYNURENINE 3-MONOOXYGENASE catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen#GO:0016709;monooxygenase activity#GO:0004497;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;oxidoreductase activity#GO:0016491 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;organelle envelope#GO:0031967;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;outer membrane#GO:0019867;cytoplasm#GO:0005737;organelle outer membrane#GO:0031968;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;membrane#GO:0016020;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;mitochondrial outer membrane#GO:0005741 oxygenase#PC00177;oxidoreductase#PC00176 HUMAN|HGNC=28036|UniProtKB=Q8IXR5 Q8IXR5 FAM178B PTHR16046:SF11 SMC5-SMC6 COMPLEX LOCALIZATION FACTOR 2 PROTEIN FAM178B HUMAN|HGNC=1773|UniProtKB=P11802 P11802 CDK4 PTHR24056:SF129 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE 4 protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824 catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;protein kinase complex#GO:1902911;intracellular anatomical structure#GO:0005622;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=9560|UniProtKB=O43242 O43242 PSMD3 PTHR10758:SF2 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;catabolic process#GO:0009056;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941 intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;proteasome regulatory particle, lid subcomplex#GO:0008541;endopeptidase complex#GO:1905369;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;peptidase complex#GO:1905368;proteasome complex#GO:0000502 protease#PC00190;protein modifying enzyme#PC00260 Cell cycle#P00013>Proteasome#P00480;Ubiquitin proteasome pathway#P00060>26S proteasome#P01489 HUMAN|HGNC=14640|UniProtKB=Q96J65 Q96J65 ABCC12 PTHR24223:SF10 ATP-BINDING CASSETTE SUB-FAMILY C ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 12 localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;transport#GO:0006810;cellular process#GO:0009987 membrane#GO:0016020;cellular anatomical structure#GO:0110165 ATP-binding cassette (ABC) transporter#PC00003 HUMAN|HGNC=25930|UniProtKB=Q8NAV1 Q8NAV1 PRPF38A PTHR23142:SF7 PRE-MRNA-SPLICING FACTOR 38A-RELATED PRE-MRNA-SPLICING FACTOR 38A mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;precatalytic spliceosome#GO:0071011;ribonucleoprotein complex#GO:1990904;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;spliceosomal complex#GO:0005681 HUMAN|HGNC=15500|UniProtKB=Q96PV6 Q96PV6 LENG8 PTHR12436:SF4 80 KDA MCM3-ASSOCIATED PROTEIN LEUKOCYTE RECEPTOR CLUSTER MEMBER 8 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 scaffold/adaptor protein#PC00226 HUMAN|HGNC=30685|UniProtKB=P40222 P40222 TXLNA PTHR16127:SF12 TAXILIN ALPHA-TAXILIN membrane traffic protein#PC00150 HUMAN|HGNC=4024|UniProtKB=P51116 P51116 FXR2 PTHR10603:SF3 FRAGILE X MENTAL RETARDATION SYNDROME-RELATED PROTEIN RNA-BINDING PROTEIN FXR2 RNA binding#GO:0003723;mRNA 3'-UTR binding#GO:0003730;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of RNA stability#GO:0043487;positive regulation of biosynthetic process#GO:0009891;localization#GO:0051179;nucleic acid transport#GO:0050657;regulation of nervous system development#GO:0051960;anatomical structure development#GO:0048856;positive regulation of translation#GO:0045727;regulation of RNA metabolic process#GO:0051252;regulation of neurogenesis#GO:0050767;regulation of macromolecule metabolic process#GO:0060255;nucleobase-containing compound transport#GO:0015931;RNA transport#GO:0050658;RNA localization#GO:0006403;regulation of cellular process#GO:0050794;establishment of RNA localization#GO:0051236;regulation of developmental process#GO:0050793;mRNA transport#GO:0051028;modulation of chemical synaptic transmission#GO:0050804;positive regulation of neurogenesis#GO:0050769;regulation of cell communication#GO:0010646;regulation of synaptic plasticity#GO:0048167;post-transcriptional regulation of gene expression#GO:0010608;positive regulation of developmental process#GO:0051094;developmental process#GO:0032502;regulation of cell differentiation#GO:0045595;transport#GO:0006810;regulation of neuronal synaptic plasticity#GO:0048168;establishment of localization#GO:0051234;regulation of biosynthetic process#GO:0009889;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;macromolecule localization#GO:0033036;regulation of macromolecule biosynthetic process#GO:0010556;nitrogen compound transport#GO:0071705;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;regulation of cell development#GO:0060284;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;animal gross anatomical part developmental process#GO:0160108;positive regulation of protein metabolic process#GO:0051247;regulation of signaling#GO:0023051;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of biological quality#GO:0065008;regulation of mRNA catabolic process#GO:0061013;regulation of biological process#GO:0050789;positive regulation of multicellular organismal process#GO:0051240;regulation of multicellular organismal development#GO:2000026;positive regulation of nervous system development#GO:0051962;regulation of mRNA stability#GO:0043488;positive regulation of cell differentiation#GO:0045597;animal organ development#GO:0048513;regulation of mRNA metabolic process#GO:1903311;regulation of protein metabolic process#GO:0051246;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604;regulation of trans-synaptic signaling#GO:0099177;positive regulation of cell development#GO:0010720;regulation of multicellular organismal process#GO:0051239 cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;neuron projection#GO:0043005;nucleus#GO:0005634;cytoplasmic stress granule#GO:0010494;membraneless organelle#GO:0043228 translational protein#PC00263;translation factor#PC00223 HUMAN|HGNC=4278|UniProtKB=P35212 P35212 GJA4 PTHR11984:SF54 CONNEXIN GAP JUNCTION ALPHA-4 PROTEIN channel activity#GO:0015267;wide pore channel activity#GO:0022829;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803 cellular process#GO:0009987;regulation of biological process#GO:0050789;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;signaling#GO:0023052;cell communication#GO:0007154 cell junction#GO:0030054;anchoring junction#GO:0070161;membrane#GO:0016020;cell-cell junction#GO:0005911;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 gap junction#PC00105;cell junction protein#PC00070 HUMAN|HGNC=2311|UniProtKB=P14384 P14384 CPM PTHR11532:SF84 PROTEASE M14 CARBOXYPEPTIDASE CARBOXYPEPTIDASE M metalloexopeptidase activity#GO:0008235;catalytic activity#GO:0003824;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;metallopeptidase activity#GO:0008237;carboxypeptidase activity#GO:0004180;hydrolase activity#GO:0016787;metallocarboxypeptidase activity#GO:0004181;exopeptidase activity#GO:0008238 biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604;protein processing#GO:0016485;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;peptide metabolic process#GO:0006518;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;proteolysis#GO:0006508;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease#PC00190 HUMAN|HGNC=610|UniProtKB=P02656 P02656 APOC3 PTHR14225:SF0 APOLIPOPROTEIN C-III APOLIPOPROTEIN C-III signaling receptor binding#GO:0005102;binding#GO:0005488;lipoprotein particle receptor binding#GO:0070325;lipid binding#GO:0008289;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;protein binding#GO:0005515;enzyme inhibitor activity#GO:0004857;phospholipid binding#GO:0005543;molecular function regulator activity#GO:0098772 biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of catabolic process#GO:0009894;neutral lipid metabolic process#GO:0006638;cholesterol homeostasis#GO:0042632;neutral lipid catabolic process#GO:0046461;triglyceride metabolic process#GO:0006641;lipid metabolic process#GO:0006629;acylglycerol metabolic process#GO:0006639;negative regulation of cellular process#GO:0048523;homeostatic process#GO:0042592;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;regulation of lipid catabolic process#GO:0050994;negative regulation of multicellular organismal process#GO:0051241;primary metabolic process#GO:0044238;negative regulation of catabolic process#GO:0009895;triglyceride homeostasis#GO:0070328;regulation of lipid metabolic process#GO:0019216;regulation of multicellular organismal process#GO:0051239;lipid catabolic process#GO:0016042;cellular process#GO:0009987;acylglycerol catabolic process#GO:0046464;chemical homeostasis#GO:0048878;metabolic process#GO:0008152;negative regulation of metabolic process#GO:0009892;glycerolipid metabolic process#GO:0046486;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;lipid homeostasis#GO:0055088;triglyceride catabolic process#GO:0019433;glycerolipid catabolic process#GO:0046503 plasma lipoprotein particle#GO:0034358;high-density lipoprotein particle#GO:0034364;extracellular protein-containing complex#GO:0140392;protein-lipid complex#GO:0032994;extracellular region#GO:0005576;lipoprotein particle#GO:1990777;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;very-low-density lipoprotein particle#GO:0034361 transfer/carrier protein#PC00219;apolipoprotein#PC00052 HUMAN|HGNC=19874|UniProtKB=Q9H0E9 Q9H0E9 BRD8 PTHR15398:SF4 BROMODOMAIN-CONTAINING PROTEIN 8 BROMODOMAIN-CONTAINING PROTEIN 8 HUMAN|HGNC=28317|UniProtKB=Q8WU08 Q8WU08 STK32A PTHR24356:SF143 SERINE/THREONINE-PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE 32A transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=27945|UniProtKB=Q8IYA8 Q8IYA8 IHO1 PTHR35662:SF1 INTERACTOR OF HORMAD1 PROTEIN 1 INTERACTOR OF HORMAD1 PROTEIN 1 reproductive process#GO:0022414;cellular component organization#GO:0016043;meiotic cell cycle process#GO:1903046;meiosis I#GO:0007127;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;nuclear chromosome segregation#GO:0098813;cell cycle#GO:0007049;cell cycle process#GO:0022402;organelle fission#GO:0048285;nuclear division#GO:0000280;meiosis I cell cycle process#GO:0061982;sexual reproduction#GO:0019953;homologous chromosome pairing at meiosis#GO:0007129;nucleobase-containing compound metabolic process#GO:0006139;meiotic DNA double-strand break formation#GO:0042138;organelle organization#GO:0006996;cellular process#GO:0009987;meiotic nuclear division#GO:0140013;macromolecule metabolic process#GO:0043170;homologous chromosome segregation#GO:0045143;cellular component organization or biogenesis#GO:0071840;meiotic chromosome segregation#GO:0045132;chromosome organization#GO:0051276;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;chromosome organization involved in meiotic cell cycle#GO:0070192;meiotic cell cycle#GO:0051321;chromosome segregation#GO:0007059 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle lumen#GO:0043233;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;condensed nuclear chromosome#GO:0000794;membraneless organelle#GO:0043228;condensed chromosome#GO:0000793 HUMAN|HGNC=16837|UniProtKB=O95711 O95711 LY86 PTHR20838:SF0 LYMPHOCYTE ANTIGEN 86 LYMPHOCYTE ANTIGEN 86 biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;response to other organism#GO:0051707;positive regulation of response to stimulus#GO:0048584;regulation of response to external stimulus#GO:0032101;defense response to other organism#GO:0098542;positive regulation of cellular process#GO:0048522;immune response#GO:0006955;positive regulation of biological process#GO:0048518;defense response to symbiont#GO:0140546;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;response to external stimulus#GO:0009605;positive regulation of response to biotic stimulus#GO:0002833;defense response#GO:0006952;innate immune response#GO:0045087;positive regulation of response to external stimulus#GO:0032103;regulation of response to stimulus#GO:0048583;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;regulation of response to biotic stimulus#GO:0002831;regulation of cell communication#GO:0010646;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;immune system process#GO:0002376 HUMAN|HGNC=25156|UniProtKB=Q96ES7 Q96ES7 SGF29 PTHR21539:SF0 SAGA-ASSOCIATED FACTOR 29 SAGA-ASSOCIATED FACTOR 29 chromatin#GO:0000785;SAGA complex#GO:0000124;intracellular membraneless organelle#GO:0043232;peptidase complex#GO:1905368;protein-containing complex#GO:0032991;transferase complex#GO:1990234;histone acetyltransferase complex#GO:0000123;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;chromosome#GO:0005694;organelle#GO:0043226;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;protein acetyltransferase complex#GO:0031248;acetyltransferase complex#GO:1902493;intracellular anatomical structure#GO:0005622;SAGA-type complex#GO:0070461 HUMAN|HGNC=162|UniProtKB=Q9Y614 Q9Y614 ACTL7B PTHR11937:SF59 ACTIN ACTIN-LIKE PROTEIN 7B structural constituent of cytoskeleton#GO:0005200;structural molecule activity#GO:0005198 actin cytoskeleton#GO:0015629;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 actin and actin related protein#PC00039 HUMAN|HGNC=14067|UniProtKB=Q8WUI4 Q8WUI4 HDAC7 PTHR10625:SF42 HISTONE DEACETYLASE HDAC1-RELATED HISTONE DEACETYLASE 7 deacylase activity#GO:0160215;histone deacetylase activity#GO:0004407;catalytic activity#GO:0003824;histone modifying activity#GO:0140993;catalytic activity, acting on a protein#GO:0140096;deacetylase activity#GO:0019213 cellular process#GO:0009987;regulation of biological process#GO:0050789;epigenetic regulation of gene expression#GO:0040029;cellular component organization#GO:0016043;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;chromatin remodeling#GO:0006338;chromatin organization#GO:0006325;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840 nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;membrane-enclosed lumen#GO:0031974;histone deacetylase complex#GO:0000118;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513 CCKR signaling map#P06959>HDAC7#P07235 HUMAN|HGNC=17662|UniProtKB=Q9UKA9 Q9UKA9 PTBP2 PTHR15592:SF16 MATRIN 3/NUCLEAR PROTEIN 220-RELATED POLYPYRIMIDINE TRACT-BINDING PROTEIN 2 mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA splicing#GO:0043484 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 RNA processing factor#PC00147 HUMAN|HGNC=1298|UniProtKB=Q9H0A9 Q9H0A9 SPATC1L PTHR22192:SF1 SPERIOLIN SPERIOLIN-LIKE PROTEIN centrosome#GO:0005813;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;microtubule cytoskeleton#GO:0015630;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232 HUMAN|HGNC=18103|UniProtKB=Q8N688 Q8N688 DEFB123 PTHR15001:SF3 BETA-DEFENSIN 123-RELATED BETA-DEFENSIN 123 defense response#GO:0006952;response to external stimulus#GO:0009605;innate immune response#GO:0045087;cell killing#GO:0001906;immune system process#GO:0002376;response to other organism#GO:0051707;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;defense response to other organism#GO:0098542;response to stimulus#GO:0050896;cellular process#GO:0009987;immune response#GO:0006955;defense response to symbiont#GO:0140546;response to stress#GO:0006950;response to biotic stimulus#GO:0009607 defense/immunity protein#PC00090;antimicrobial response protein#PC00051 HUMAN|HGNC=25313|UniProtKB=Q9H0I9 Q9H0I9 TKTL2 PTHR43195:SF4 TRANSKETOLASE TRANSKETOLASE-LIKE PROTEIN 2 transferase activity#GO:0016740;catalytic activity#GO:0003824;transketolase or transaldolase activity#GO:0016744;heterocyclic compound binding#GO:1901363;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;binding#GO:0005488;transketolase activity#GO:0004802;cation binding#GO:0043169 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 transketolase#PC00221;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=37491|UniProtKB=F8W0I5 F8W0I5 NPIPB12 PTHR15438:SF5 NUCLEAR PORE COMPLEX INTERACTING PROTEIN NUCLEAR PORE COMPLEX INTERACTING PROTEIN FAMILY MEMBER B3-RELATED HUMAN|HGNC=20995|UniProtKB=Q9Y294 Q9Y294 ASF1A PTHR12040:SF8 ANTI-SILENCING PROTEIN 1 HISTONE CHAPERONE ASF1A protein binding#GO:0005515;binding#GO:0005488;histone binding#GO:0042393 cellular component organization or biogenesis#GO:0071840;chromatin organization#GO:0006325;cellular component organization#GO:0016043;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694;chromatin#GO:0000785;nucleus#GO:0005634;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=28038|UniProtKB=Q9P0N8 Q9P0N8 MARCHF2 PTHR46065:SF4 E3 UBIQUITIN-PROTEIN LIGASE MARCH 2/3 FAMILY MEMBER E3 UBIQUITIN-PROTEIN LIGASE MARCHF2 catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity, acting on a protein#GO:0140096;ubiquitin-protein transferase activity#GO:0004842;aminoacyltransferase activity#GO:0016755 primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein modification by small protein conjugation#GO:0032446;cellular process#GO:0009987;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=11063|UniProtKB=Q01650 Q01650 SLC7A5 PTHR11785:SF315 AMINO ACID TRANSPORTER LARGE NEUTRAL AMINO ACIDS TRANSPORTER SMALL SUBUNIT 1 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;neutral L-amino acid transmembrane transporter activity#GO:0015175;amino acid transmembrane transporter activity#GO:0015171;L-amino acid transmembrane transporter activity#GO:0015179 neutral amino acid transport#GO:0015804;establishment of localization#GO:0051234;amino acid transmembrane transport#GO:0003333;transmembrane transport#GO:0055085;localization#GO:0051179;amino acid transport#GO:0006865;transport#GO:0006810;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227 HUMAN|HGNC=7598|UniProtKB=O94832 O94832 MYO1D PTHR13140:SF417 MYOSIN UNCONVENTIONAL MYOSIN-ID catalytic activity#GO:0003824;polypeptide conformation or assembly isomerase activity#GO:0120544;microfilament motor activity#GO:0000146;macromolecular conformation isomerase activity#GO:0120543;ATP-dependent activity#GO:0140657;cytoskeletal motor activity#GO:0003774;isomerase activity#GO:0016853 cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;endocytosis#GO:0006897;actin filament-based movement#GO:0030048;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cellular component organization or biogenesis#GO:0071840;localization#GO:0051179;establishment of localization#GO:0051234;import into cell#GO:0098657;actin filament-based process#GO:0030029;transport#GO:0006810 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;actin cytoskeleton#GO:0015629;microvillus#GO:0005902;actin-based cell projection#GO:0098858;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;cytoplasm#GO:0005737;membrane#GO:0016020;cell periphery#GO:0071944;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856 actin binding motor protein#PC00040 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HUMAN|HGNC=18668|UniProtKB=O15156 O15156 ZBTB7B PTHR46105:SF4 AGAP004733-PA ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 7B sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987 regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;regulation of gene expression#GO:0010468;positive regulation of gene expression#GO:0010628;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=24179|UniProtKB=Q9C073 Q9C073 FAM117A PTHR14972:SF7 AGAP011572-PA PROTEIN FAM117A HUMAN|HGNC=1809|UniProtKB=Q9Y6F8 Q9Y6F8 CDY1 PTHR43684:SF6 FAMILY NOT NAMED TESTIS-SPECIFIC CHROMODOMAIN PROTEIN Y 1-RELATED transcription corepressor activity#GO:0003714;catalytic activity#GO:0003824;transcription coregulator activity#GO:0003712;molecular adaptor activity#GO:0060090;histone H3K9me2/3 reader activity#GO:0062072;histone reader activity#GO:0140566;intramolecular oxidoreductase activity#GO:0016860;isomerase activity#GO:0016853;chromatin-protein adaptor activity#GO:0140463;protein-macromolecule adaptor activity#GO:0030674;histone H3 reader activity#GO:0140006;transcription regulator activity#GO:0140110 lipid catabolic process#GO:0016042;cellular process#GO:0009987;metabolic process#GO:0008152;fatty acid oxidation#GO:0019395;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;small molecule metabolic process#GO:0044281;cell differentiation#GO:0030154;gamete generation#GO:0007276;cell development#GO:0048468;cellular process involved in reproduction in multicellular organism#GO:0022412;small molecule catabolic process#GO:0044282;oxoacid metabolic process#GO:0043436;spermatid differentiation#GO:0048515;fatty acid catabolic process#GO:0009062;carboxylic acid catabolic process#GO:0046395;monocarboxylic acid catabolic process#GO:0072329;male gamete generation#GO:0048232;fatty acid metabolic process#GO:0006631;spermatogenesis#GO:0007283;developmental process#GO:0032502;lipid metabolic process#GO:0006629;fatty acid beta-oxidation#GO:0006635;lipid modification#GO:0030258;cellular developmental process#GO:0048869;primary metabolic process#GO:0044238;developmental process involved in reproduction#GO:0003006;germ cell development#GO:0007281;catabolic process#GO:0009056;reproductive process#GO:0022414;sexual reproduction#GO:0019953;spermatid development#GO:0007286;lipid oxidation#GO:0034440;anatomical structure development#GO:0048856;multicellular organismal reproductive process#GO:0048609 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;peroxisomal matrix#GO:0005782;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microbody#GO:0042579;nucleus#GO:0005634;peroxisome#GO:0005777;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974 HUMAN|HGNC=9357|UniProtKB=P51888 P51888 PRELP PTHR45712:SF8 AGAP008170-PA PROLARGIN glycosaminoglycan binding#GO:0005539;carbohydrate derivative binding#GO:0097367;binding#GO:0005488;heparin binding#GO:0008201 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=19751|UniProtKB=O75044 O75044 SRGAP2 PTHR14166:SF6 SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 2-RELATED enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme activator activity#GO:0008047 regulation of locomotion#GO:0040012;nervous system development#GO:0007399;biological regulation#GO:0065007;negative regulation of cell motility#GO:2000146;negative regulation of locomotion#GO:0040013;multicellular organismal process#GO:0032501;regulation of synapse assembly#GO:0051963;multicellular organism development#GO:0007275;regulation of cell migration#GO:0030334;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;negative regulation of cell migration#GO:0030336;regulation of cellular component biogenesis#GO:0044087;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of biological quality#GO:0065008;system development#GO:0048731;anatomical structure development#GO:0048856;regulation of synapse structure or activity#GO:0050803;regulation of cell motility#GO:2000145;regulation of cell junction assembly#GO:1901888;regulation of synapse organization#GO:0050807;animal gross anatomical part developmental process#GO:0160108 neuron spine#GO:0044309;plasma membrane bounded cell projection#GO:0120025;somatodendritic compartment#GO:0036477;cell projection#GO:0042995;glutamatergic synapse#GO:0098978;cellular anatomical structure#GO:0110165;synapse#GO:0045202;dendritic spine#GO:0043197;neuron projection#GO:0043005;postsynapse#GO:0098794;cell junction#GO:0030054;dendritic tree#GO:0097447;dendrite#GO:0030425 G-protein modulator#PC00022;GTPase-activating protein#PC00257 PDGF signaling pathway#P00047>Rho#P01174 HUMAN|HGNC=11065|UniProtKB=Q9UM01 Q9UM01 SLC7A7 PTHR11785:SF303 AMINO ACID TRANSPORTER Y+L AMINO ACID TRANSPORTER 1 L-amino acid transmembrane transporter activity#GO:0015179;basic amino acid transmembrane transporter activity#GO:0015174;carboxylic acid transmembrane transporter activity#GO:0046943;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;amino acid transmembrane transporter activity#GO:0015171 transmembrane transport#GO:0055085;amino acid transmembrane transport#GO:0003333;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810;amino acid transport#GO:0006865;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227 HUMAN|HGNC=4494|UniProtKB=O15354 O15354 GPR37 PTHR46216:SF3 PROSAPOSIN RECEPTOR GPR37 FAMILY MEMBER PROSAPOSIN RECEPTOR GPR37 transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930 positive regulation of signaling#GO:0023056;cell communication#GO:0007154;regulation of intracellular signal transduction#GO:1902531;G protein-coupled receptor signaling pathway#GO:0007186;regulation of signaling#GO:0023051;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;response to stimulus#GO:0050896;regulation of cell communication#GO:0010646;signaling#GO:0023052;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;positive regulation of MAPK cascade#GO:0043410;adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway#GO:0007193;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;regulation of response to stimulus#GO:0048583;regulation of MAPK cascade#GO:0043408;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518 signaling receptor complex#GO:0043235;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021 Parkinson disease#P00049>Pael-R#P01229 HUMAN|HGNC=18476|UniProtKB=Q71UM5 Q71UM5 RPS27L PTHR11594:SF2 40S RIBOSOMAL PROTEIN S27 RIBOSOMAL PROTEIN ES27-LIKE structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;gene expression#GO:0010467;translation#GO:0006412;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;protein metabolic process#GO:0019538;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;protein biosynthetic process#GO:0160307 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytosolic ribosome#GO:0022626;cytosol#GO:0005829;ribosome#GO:0005840;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;cytosolic small ribosomal subunit#GO:0022627;small ribosomal subunit#GO:0015935;intracellular organelle#GO:0043229 ribosomal protein#PC00202;translational protein#PC00263 HUMAN|HGNC=26306|UniProtKB=Q658Y4 Q658Y4 FAM91A1 PTHR28441:SF4 PROTEIN FAM91A1 PROTEIN FAM91A1 protein transport#GO:0015031;intracellular protein localization#GO:0008104;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;macromolecule localization#GO:0033036 intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus subcompartment#GO:0098791;intracellular vesicle#GO:0097708;vesicle#GO:0031982 HUMAN|HGNC=12392|UniProtKB=Q99615 Q99615 DNAJC7 PTHR44200:SF1 DNAJ HOMOLOG SUBFAMILY C MEMBER 7 DNAJ HOMOLOG SUBFAMILY C MEMBER 7 chaperone#PC00072 HUMAN|HGNC=3327|UniProtKB=P15502 P15502 ELN PTHR24018:SF5 ELASTIN ELASTIN extracellular matrix structural constituent#GO:0005201;structural molecule activity#GO:0005198 multicellular organismal process#GO:0032501;heart development#GO:0007507;cellular process#GO:0009987;vasculature development#GO:0001944;animal organ development#GO:0048513;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;developmental process#GO:0032502;tissue remodeling#GO:0048771;animal organ morphogenesis#GO:0009887;circulatory system development#GO:0072359;blood vessel development#GO:0001568;anatomical structure morphogenesis#GO:0009653;heart morphogenesis#GO:0003007;cellular component organization#GO:0016043;external encapsulating structure organization#GO:0045229;system development#GO:0048731;extracellular matrix organization#GO:0030198;anatomical structure development#GO:0048856;extracellular structure organization#GO:0043062;animal gross anatomical part developmental process#GO:0160108 cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;interstitial matrix#GO:0005614;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;supramolecular fiber#GO:0099512;extracellular region#GO:0005576 structural protein#PC00211 HUMAN|HGNC=23993|UniProtKB=Q4L235 Q4L235 AASDH PTHR44394:SF1 BETA-ALANINE-ACTIVATING ENZYME BETA-ALANINE-ACTIVATING ENZYME ligase#PC00142;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=24694|UniProtKB=Q7RTP6 Q7RTP6 MICAL3 PTHR23167:SF51 CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED [F-ACTIN]-MONOOXYGENASE MICAL3 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;cytoskeletal protein binding#GO:0008092;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen#GO:0016709;monooxygenase activity#GO:0004497;oxidoreductase activity#GO:0016491;actin binding#GO:0003779;binding#GO:0005488;protein binding#GO:0005515 organelle organization#GO:0006996;cellular component organization#GO:0016043;actin filament depolymerization#GO:0030042;cellular process#GO:0009987;actin polymerization or depolymerization#GO:0008154;actin cytoskeleton organization#GO:0030036;protein-containing complex disassembly#GO:0032984;cytoskeleton organization#GO:0007010;protein depolymerization#GO:0051261;actin filament-based process#GO:0030029;cellular component organization or biogenesis#GO:0071840;cellular component disassembly#GO:0022411;actin filament organization#GO:0007015;supramolecular fiber organization#GO:0097435;protein-containing complex organization#GO:0043933 scaffold/adaptor protein#PC00226 HUMAN|HGNC=20321|UniProtKB=Q5TAP6 Q5TAP6 UTP14C PTHR14150:SF16 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14 HOMOLOG C enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;preribosome#GO:0030684;nucleolus#GO:0005730;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;small-subunit processome#GO:0032040;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 RNA metabolism protein#PC00031 HUMAN|HGNC=2185|UniProtKB=Q03692 Q03692 COL10A1 PTHR24023:SF880 COLLAGEN ALPHA COLLAGEN ALPHA-1(X) CHAIN extracellular matrix structural constituent#GO:0005201;structural molecule activity#GO:0005198 external encapsulating structure organization#GO:0045229;cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;cellular process#GO:0009987;extracellular structure organization#GO:0043062;cellular component organization#GO:0016043 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;supramolecular complex#GO:0099080;interstitial matrix#GO:0005614;extracellular region#GO:0005576;extracellular protein-containing complex#GO:0140392 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 Integrin signalling pathway#P00034>Collagen#P00922 HUMAN|HGNC=28386|UniProtKB=Q96KX1 Q96KX1 C4orf36 PTHR38002:SF1 C4ORF36 ISOFORM 11 CHROMOSOME 8 C4ORF36 HOMOLOG HUMAN|HGNC=543|UniProtKB=P08758 P08758 ANXA5 PTHR10502:SF26 ANNEXIN ANNEXIN A5 lipid binding#GO:0008289;phosphatidylserine binding#GO:0001786;small molecule binding#GO:0036094;binding#GO:0005488;phospholipid binding#GO:0005543;anion binding#GO:0043168;ion binding#GO:0043167 vesicle membrane#GO:0012506;membrane#GO:0016020;vesicle#GO:0031982;cell periphery#GO:0071944;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622 calcium-binding protein#PC00060 Gonadotropin-releasing hormone receptor pathway#P06664>Annexin A5#G06684;Gonadotropin-releasing hormone receptor pathway#P06664>Annexin A5#G06897;Gonadotropin-releasing hormone receptor pathway#P06664>Annexin A5#P06814 HUMAN|HGNC=23114|UniProtKB=P55199 P55199 ELL PTHR23288:SF9 OCCLUDIN AND RNA POLYMERASE II ELONGATION FACTOR ELL RNA POLYMERASE II ELONGATION FACTOR ELL sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987 positive regulation of transcription by RNA polymerase II#GO:0045944;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;gene expression#GO:0010467;regulation of DNA-templated transcription elongation#GO:0032784;nucleic acid biosynthetic process#GO:0141187;regulation of transcription elongation by RNA polymerase II#GO:0034243;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;RNA metabolic process#GO:0016070;regulation of biological process#GO:0050789;snRNA transcription#GO:0009301;positive regulation of DNA-templated transcription, elongation#GO:0032786;regulation of transcription by RNA polymerase II#GO:0006357;transcription by RNA polymerase II#GO:0006366;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of cellular process#GO:0048522;macromolecule biosynthetic process#GO:0009059;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;positive regulation of biosynthetic process#GO:0009891;snRNA metabolic process#GO:0016073;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;snRNA transcription by RNA polymerase II#GO:0042795;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;positive regulation of RNA metabolic process#GO:0051254 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;transcription elongation factor complex#GO:0008023;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;protein-containing complex#GO:0032991;nucleoplasm#GO:0005654;organelle#GO:0043226 general transcription factor#PC00259 HUMAN|HGNC=12388|UniProtKB=Q16762 Q16762 TST PTHR11364:SF6 THIOSULFATE SULFERTANSFERASE THIOSULFATE SULFURTRANSFERASE catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring sulphur-containing groups#GO:0016782;sulfurtransferase activity#GO:0016783 tRNA thio-modification#GO:0034227;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187;tRNA modification#GO:0006400;RNA biosynthetic process#GO:0032774;tRNA wobble position uridine thiolation#GO:0002143;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;tRNA wobble uridine modification#GO:0002098;tRNA wobble base modification#GO:0002097;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 transferase#PC00220 HUMAN|HGNC=9545|UniProtKB=P28062 P28062 PSMB8 PTHR11599:SF53 PROTEASOME SUBUNIT ALPHA/BETA PROTEASOME SUBUNIT BETA TYPE-8 hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity#GO:0003824 proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152 cytosol#GO:0005829;nucleus#GO:0005634;proteasome complex#GO:0000502;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;peptidase complex#GO:1905368;endopeptidase complex#GO:1905369;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227 protease#PC00190;protein modifying enzyme#PC00260 HUMAN|HGNC=35428|UniProtKB=P56277 P56277 CMC4 PTHR15590:SF0 CX9C MOTIF-CONTAINING PROTEIN 4 CX9C MOTIF-CONTAINING PROTEIN 4 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrial intermembrane space#GO:0005758;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle envelope#GO:0031967;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;mitochondrion#GO:0005739;mitochondrial envelope#GO:0005740 HUMAN|HGNC=44200|UniProtKB=A6NFA1 A6NFA1 TRABD2B PTHR31120:SF8 METALLOPROTEASE TIKI METALLOPROTEASE TIKI2 Wnt-protein binding#GO:0017147;protein binding#GO:0005515;binding#GO:0005488 negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of Wnt signaling pathway#GO:0030178;regulation of cellular process#GO:0050794;negative regulation of response to stimulus#GO:0048585;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111;negative regulation of signal transduction#GO:0009968;negative regulation of signaling#GO:0023057;negative regulation of cellular process#GO:0048523;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;negative regulation of cell communication#GO:0010648 cellular anatomical structure#GO:0110165;organelle#GO:0043226;organelle membrane#GO:0031090;plasma membrane#GO:0005886;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;cell periphery#GO:0071944 protease#PC00190;metalloprotease#PC00153;protein modifying enzyme#PC00260 HUMAN|HGNC=26192|UniProtKB=Q9H6A0 Q9H6A0 DENND2D PTHR15288:SF2 DENN DOMAIN-CONTAINING PROTEIN 2 DENN DOMAIN-CONTAINING PROTEIN 2D guanyl-nucleotide exchange factor activity#GO:0005085;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=30083|UniProtKB=Q6PIL6 Q6PIL6 KCNIP4 PTHR23055:SF30 CALCIUM BINDING PROTEINS KV CHANNEL-INTERACTING PROTEIN 4 calcium ion binding#GO:0005509;potassium channel regulator activity#GO:0015459;transporter regulator activity#GO:0141108;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;cation binding#GO:0043169;channel regulator activity#GO:0016247;metal ion binding#GO:0046872;ion channel regulator activity#GO:0099106;molecular function regulator activity#GO:0098772 regulation of transport#GO:0051049;regulation of localization#GO:0032879;regulation of monoatomic cation transmembrane transport#GO:1904062;regulation of cellular process#GO:0050794;regulation of monoatomic ion transport#GO:0043269;regulation of metal ion transport#GO:0010959;biological regulation#GO:0065007;regulation of transmembrane transport#GO:0034762;regulation of monoatomic ion transmembrane transport#GO:0034765;regulation of biological process#GO:0050789 monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane protein complex#GO:0098796;membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;cation channel complex#GO:0034703;voltage-gated potassium channel complex#GO:0008076 calmodulin-related#PC00061 HUMAN|HGNC=7548|UniProtKB=P10244 P10244 MYBL2 PTHR45614:SF30 MYB PROTEIN-RELATED MYB-RELATED PROTEIN B sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 positive regulation of RNA metabolic process#GO:0051254;regulation of transcription by RNA polymerase II#GO:0006357;mitotic cell cycle#GO:0000278;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cell cycle#GO:0007049;regulation of RNA metabolic process#GO:0051252;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of transcription by RNA polymerase II#GO:0045944 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 homeodomain transcription factor#PC00119 HUMAN|HGNC=6970|UniProtKB=P40925 P40925 MDH1 PTHR23382:SF34 MALATE DEHYDROGENASE MALATE DEHYDROGENASE, CYTOPLASMIC oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491 metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;organophosphate metabolic process#GO:0019637;NAD+ metabolic process#GO:0019674;cellular process#GO:0009987;nicotinamide nucleotide metabolic process#GO:0046496;nucleobase-containing compound metabolic process#GO:0006139;oxoacid metabolic process#GO:0043436;pyridine-containing compound metabolic process#GO:0072524;nucleotide metabolic process#GO:0009117;phosphorus metabolic process#GO:0006793;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 dehydrogenase#PC00092 TCA cycle#P00051>Malate Dehydrogenase#P01270 HUMAN|HGNC=9541|UniProtKB=P28070 P28070 PSMB4 PTHR11599:SF5 PROTEASOME SUBUNIT ALPHA/BETA PROTEASOME SUBUNIT BETA TYPE-4 proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152 organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;peptidase complex#GO:1905368;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cytosol#GO:0005829;nucleus#GO:0005634;proteasome complex#GO:0000502;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;endopeptidase complex#GO:1905369;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 protease#PC00190;protein modifying enzyme#PC00260 Parkinson disease#P00049>20S proteasome#P01227 HUMAN|HGNC=1014|UniProtKB=P11274 P11274 BCR PTHR23182:SF3 BREAKPOINT CLUSTER REGION PROTEIN BCR BREAKPOINT CLUSTER REGION PROTEIN molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047 regulation of Rho protein signal transduction#GO:0035023;regulation of trans-synaptic signaling#GO:0099177;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of signal transduction#GO:0009966;modulation of chemical synaptic transmission#GO:0050804;biological regulation#GO:0065007;regulation of biological process#GO:0050789;regulation of small GTPase mediated signal transduction#GO:0051056;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583 cell junction#GO:0030054;postsynaptic density#GO:0014069;plasma membrane#GO:0005886;glutamatergic synapse#GO:0098978;synapse#GO:0045202;neuron to neuron synapse#GO:0098984;cellular anatomical structure#GO:0110165;organelle#GO:0043226;postsynaptic specialization#GO:0099572;asymmetric synapse#GO:0032279;cell periphery#GO:0071944;postsynapse#GO:0098794;membrane#GO:0016020 G-protein modulator#PC00022 HUMAN|HGNC=27418|UniProtKB=A6NCS6 A6NCS6 C2orf72 PTHR35675:SF1 HYPOTHETICAL PROTEIN LOC100362216 SIMILAR TO HUMAN CHROMOSOME 2 OPEN READING FRAME 72 HUMAN|HGNC=27101|UniProtKB=Q5UE93 Q5UE93 PIK3R6 PTHR15593:SF1 PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 6 molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;enzyme regulator activity#GO:0030234 regulation of immune effector process#GO:0002697;cell communication#GO:0007154;regulation of leukocyte mediated cytotoxicity#GO:0001910;G protein-coupled receptor signaling pathway#GO:0007186;regulation of lymphocyte mediated immunity#GO:0002706;regulation of defense response#GO:0031347;regulation of cell killing#GO:0031341;regulation of immune response#GO:0050776;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;response to stimulus#GO:0050896;regulation of response to biotic stimulus#GO:0002831;signaling#GO:0023052;regulation of natural killer cell mediated immunity#GO:0002715;cellular response to stimulus#GO:0051716;regulation of leukocyte mediated immunity#GO:0002703;regulation of biological process#GO:0050789;regulation of innate immune response#GO:0045088;regulation of response to stress#GO:0080134;regulation of response to stimulus#GO:0048583;regulation of response to external stimulus#GO:0032101;regulation of natural killer cell mediated cytotoxicity#GO:0042269;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;membrane#GO:0016020;membrane protein complex#GO:0098796;extrinsic component of membrane#GO:0019898;catalytic complex#GO:1902494;transferase complex#GO:1990234;transferase complex, transferring phosphorus-containing groups#GO:0061695 protein-binding activity modulator#PC00095;kinase modulator#PC00140 Endothelin signaling pathway#P00019>PI3K#P00577;EGF receptor signaling pathway#P00018>PI3K#P00557 HUMAN|HGNC=17879|UniProtKB=Q8N0S6 Q8N0S6 CENPL PTHR31740:SF2 CENTROMERE PROTEIN L CENTROMERE PROTEIN L HUMAN|HGNC=3619|UniProtKB=P08637 P08637 FCGR3A PTHR11481:SF103 IMMUNOGLOBULIN FC RECEPTOR LOW AFFINITY IMMUNOGLOBULIN GAMMA FC REGION RECEPTOR III-A-RELATED transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell surface receptor signaling pathway#GO:0007166;immune effector process#GO:0002252;biological regulation#GO:0065007;adaptive immune response#GO:0002250;immune response#GO:0006955;signal transduction#GO:0007165;cellular process#GO:0009987;cell communication#GO:0007154;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449;immunoglobulin mediated immune response#GO:0016064;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immune system process#GO:0002376;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716 cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020;plasma membrane#GO:0005886;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=15468|UniProtKB=Q9NP97 Q9NP97 DYNLRB1 PTHR10779:SF17 DYNEIN LIGHT CHAIN ROADBLOCK DYNEIN LIGHT CHAIN ROADBLOCK-TYPE 1 binding#GO:0005488;protein binding#GO:0005515 cellular process#GO:0009987;microtubule-based process#GO:0007017;microtubule-based movement#GO:0007018 microtubule organizing center#GO:0005815;centrosome#GO:0005813;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;cytoplasmic dynein complex#GO:0005868;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;dynein complex#GO:0030286;organelle#GO:0043226;cellular anatomical structure#GO:0110165 microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=24515|UniProtKB=O95563 O95563 MPC2 PTHR14154:SF154 UPF0041 BRAIN PROTEIN 44-RELATED MITOCHONDRIAL PYRUVATE CARRIER 2 monocarboxylic acid transmembrane transporter activity#GO:0008028;carboxylic acid transmembrane transporter activity#GO:0046943;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 intracellular transport#GO:0046907;carboxylic acid transport#GO:0046942;mitochondrial transmembrane transport#GO:1990542;transport#GO:0006810;organic acid transport#GO:0015849;localization#GO:0051179;transmembrane transport#GO:0055085;cellular localization#GO:0051641;establishment of localization#GO:0051234;monocarboxylic acid transport#GO:0015718;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;mitochondrial transport#GO:0006839;carboxylic acid transmembrane transport#GO:1905039 inner mitochondrial membrane protein complex#GO:0098800;organelle membrane#GO:0031090;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrial membrane#GO:0031966;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle envelope#GO:0031967;membrane protein complex#GO:0098796;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=2049|UniProtKB=O95471 O95471 CLDN7 PTHR12002:SF78 CLAUDIN CLAUDIN-7 cellular process#GO:0009987;cellular component biogenesis#GO:0044085;cell junction assembly#GO:0034329;cellular component organization#GO:0016043;cellular component assembly#GO:0022607;cell junction organization#GO:0034330;cell-cell junction organization#GO:0045216;cell-cell junction assembly#GO:0007043;cellular component organization or biogenesis#GO:0071840 anchoring junction#GO:0070161;tight junction#GO:0070160;cell junction#GO:0030054;apical junction complex#GO:0043296;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;bicellular tight junction#GO:0005923;cell periphery#GO:0071944;membrane#GO:0016020;cell-cell junction#GO:0005911 tight junction#PC00214;cell junction protein#PC00070 HUMAN|HGNC=16472|UniProtKB=Q9UMX9 Q9UMX9 SLC45A2 PTHR19432:SF34 SUGAR TRANSPORTER MEMBRANE-ASSOCIATED TRANSPORTER PROTEIN secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;proton transmembrane transporter activity#GO:0015078;active transmembrane transporter activity#GO:0022804;solute:monoatomic cation symporter activity#GO:0015294;monoatomic ion transmembrane transporter activity#GO:0015075;symporter activity#GO:0015293;solute:proton symporter activity#GO:0015295;monoatomic cation transmembrane transporter activity#GO:0008324;carbohydrate transmembrane transporter activity#GO:0015144 cellular process#GO:0009987;developmental pigmentation#GO:0048066;phenol-containing compound metabolic process#GO:0018958;pigment metabolic process#GO:0042440;phenol-containing compound biosynthetic process#GO:0046189;biosynthetic process#GO:0009058;pigment biosynthetic process#GO:0046148;pigmentation#GO:0043473;secondary metabolite biosynthetic process#GO:0044550;metabolic process#GO:0008152;secondary metabolic process#GO:0019748;melanin biosynthetic process#GO:0042438 vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;vesicle membrane#GO:0012506;cytoplasm#GO:0005737;melanosome#GO:0042470;cytoplasmic vesicle membrane#GO:0030659;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090 secondary carrier transporter#PC00258 HUMAN|HGNC=12538|UniProtKB=P19224 P19224 UGT1A6 PTHR48050:SF7 STEROL 3-BETA-GLUCOSYLTRANSFERASE UDP-GLUCURONOSYLTRANSFERASE 1A6 molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;protein binding#GO:0005515;enzyme binding#GO:0019899;binding#GO:0005488;molecular function regulator activity#GO:0098772;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;enzyme inhibitor activity#GO:0004857;catalytic activity#GO:0003824;transferase activity#GO:0016740 developmental process#GO:0032502;lipid metabolic process#GO:0006629;sterol metabolic process#GO:0016125;pigment metabolic process#GO:0042440;hormone metabolic process#GO:0042445;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;response to steroid hormone#GO:0048545;anatomical structure development#GO:0048856;system development#GO:0048731;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;metabolic process#GO:0008152;multicellular organism development#GO:0007275;animal organ development#GO:0048513;cellular response to steroid hormone stimulus#GO:0071383;response to hormone#GO:0009725;cellular process#GO:0009987;response to chemical#GO:0042221;response to lipid#GO:0033993;cellular response to lipid#GO:0071396;steroid metabolic process#GO:0008202;cellular response to chemical stimulus#GO:0070887;animal gross anatomical part developmental process#GO:0160108;estrogen metabolic process#GO:0008210;regulation of biological quality#GO:0065008;response to endogenous stimulus#GO:0009719;regulation of hormone levels#GO:0010817;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;cellular response to hormone stimulus#GO:0032870;liver development#GO:0001889 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 transferase#PC00220;glycosyltransferase#PC00111 HUMAN|HGNC=10345|UniProtKB=P18077 P18077 RPL35A PTHR10902:SF36 60S RIBOSOMAL PROTEIN L35A LARGE RIBOSOMAL SUBUNIT PROTEIN EL33 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 translation#GO:0006412;ribosomal large subunit biogenesis#GO:0042273;ribosome biogenesis#GO:0042254;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;ribonucleoprotein complex biogenesis#GO:0022613;cytoplasmic translation#GO:0002181;protein biosynthetic process#GO:0160307;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;biosynthetic process#GO:0009058;gene expression#GO:0010467 large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytosolic large ribosomal subunit#GO:0022625;cytosolic ribosome#GO:0022626;cytosol#GO:0005829;ribosome#GO:0005840;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391 translational protein#PC00263;ribosomal protein#PC00202 HUMAN|HGNC=22998|UniProtKB=Q7Z404 Q7Z404 TMC4 PTHR23302:SF45 TRANSMEMBRANE CHANNEL-RELATED VOLTAGE-GATED CHLORIDE CHANNEL TMC4 chloride transmembrane transporter activity#GO:0015108;passive transmembrane transporter activity#GO:0022803;chloride channel activity#GO:0005254;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic anion transmembrane transporter activity#GO:0008509;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;voltage-gated monoatomic anion channel activity#GO:0008308;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;monoatomic anion channel activity#GO:0005253;voltage-gated channel activity#GO:0022832;channel activity#GO:0015267 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133 HUMAN|HGNC=29062|UniProtKB=Q86YS7 Q86YS7 C2CD5 PTHR37412:SF2 C2 DOMAIN-CONTAINING PROTEIN 5 C2 DOMAIN-CONTAINING PROTEIN 5 phospholipid binding#GO:0005543;metal ion binding#GO:0046872;lipid binding#GO:0008289;cation binding#GO:0043169;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;calcium ion binding#GO:0005509 biological regulation#GO:0065007;macromolecule localization#GO:0033036;positive regulation of cellular process#GO:0048522;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;transport#GO:0006810;regulation of cellular process#GO:0050794;regulation of transmembrane transport#GO:0034762;protein localization to plasma membrane#GO:0072659;localization#GO:0051179;regulation of establishment of protein localization#GO:0070201;localization within membrane#GO:0051668;cellular process#GO:0009987;positive regulation of transport#GO:0051050;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;positive regulation of biological process#GO:0048518;intracellular protein transmembrane transport#GO:0065002;regulation of transport#GO:0051049;regulation of localization#GO:0032879;positive regulation of vesicle fusion#GO:0031340;protein localization to cell periphery#GO:1990778;protein transmembrane transport#GO:0071806;intracellular protein transport#GO:0006886;regulation of cellular component organization#GO:0051128;protein localization to membrane#GO:0072657;regulation of organelle organization#GO:0033043;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;cellular localization#GO:0051641;transmembrane transport#GO:0055085;positive regulation of organelle organization#GO:0010638;protein transport#GO:0015031;regulation of protein localization#GO:0032880;positive regulation of cellular component organization#GO:0051130 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 HUMAN|HGNC=11829|UniProtKB=O95049 O95049 TJP3 PTHR13865:SF11 TIGHT JUNCTION PROTEIN TIGHT JUNCTION PROTEIN ZO-3 protein binding#GO:0005515;cell adhesion molecule binding#GO:0050839;binding#GO:0005488 biological regulation#GO:0065007;blood circulation#GO:0008015;epithelium development#GO:0060429;epithelial cell differentiation#GO:0030855;anatomical structure homeostasis#GO:0060249;tissue development#GO:0009888;multicellular organismal process#GO:0032501;cellular process#GO:0009987;macromolecule localization#GO:0033036;cell-cell adhesion#GO:0098609;intracellular protein localization#GO:0008104;system process#GO:0003008;multicellular organismal-level homeostasis#GO:0048871;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;endothelial cell differentiation#GO:0045446;cell-cell junction organization#GO:0045216;developmental process#GO:0032502;homeostatic process#GO:0042592;cell development#GO:0048468;cell differentiation#GO:0030154;cell junction organization#GO:0034330;cellular component organization#GO:0016043;tissue homeostasis#GO:0001894;regulation of biological quality#GO:0065008;localization#GO:0051179;anatomical structure development#GO:0048856;cell adhesion#GO:0007155;protein localization to cell junction#GO:1902414;circulatory system process#GO:0003013;animal gross anatomical part developmental process#GO:0160108 anchoring junction#GO:0070161;cell junction#GO:0030054;tight junction#GO:0070160;apical junction complex#GO:0043296;plasma membrane#GO:0005886;bicellular tight junction#GO:0005923;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;cell-cell junction#GO:0005911 tight junction#PC00214;cell junction protein#PC00070 HUMAN|HGNC=35202|UniProtKB=C9J798 C9J798 RASA4B PTHR10194:SF4 RAS GTPASE-ACTIVATING PROTEINS RAS GTPASE-ACTIVATING PROTEIN 4-RELATED GTPase-activating protein#PC00257 FGF signaling pathway#P00021>RasGAP#P00646;PDGF signaling pathway#P00047>RasGAP#P01152;EGF receptor signaling pathway#P00018>GAP#P00546 HUMAN|HGNC=16995|UniProtKB=Q969M2 Q969M2 GJA10 PTHR11984:SF9 CONNEXIN GAP JUNCTION ALPHA-10 PROTEIN channel activity#GO:0015267;wide pore channel activity#GO:0022829;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803 cellular process#GO:0009987;regulation of biological process#GO:0050789;cell communication#GO:0007154;signaling#GO:0023052;biological regulation#GO:0065007;cell-cell signaling#GO:0007267 cell junction#GO:0030054;anchoring junction#GO:0070161;cell-cell junction#GO:0005911;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cell junction protein#PC00070;gap junction#PC00105 HUMAN|HGNC=33391|UniProtKB=Q5R3K3 Q5R3K3 CALHM6 PTHR32261:SF4 CALCIUM HOMEOSTASIS MODULATOR PROTEIN CALCIUM HOMEOSTASIS MODULATOR PROTEIN 6 monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;passive transmembrane transporter activity#GO:0022803;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic cation channel activity#GO:0005261 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 voltage-gated ion channel#PC00241 HUMAN|HGNC=15476|UniProtKB=P63167 P63167 DYNLL1 PTHR11886:SF118 DYNEIN LIGHT CHAIN DYNEIN LIGHT CHAIN 1, CYTOPLASMIC binding#GO:0005488;protein binding#GO:0005515 microtubule-based process#GO:0007017;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;motile cilium assembly#GO:0044458;cellular component organization or biogenesis#GO:0071840;transport#GO:0006810;intracellular transport#GO:0046907;plasma membrane bounded cell projection assembly#GO:0120031;plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton-dependent intracellular transport#GO:0030705;cellular component assembly#GO:0022607;cellular process#GO:0009987;cell projection assembly#GO:0030031;establishment of localization in cell#GO:0051649;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cilium organization#GO:0044782;cellular localization#GO:0051641;localization#GO:0051179;microtubule-based transport#GO:0099111;organelle assembly#GO:0070925;intraciliary transport#GO:0042073;intraciliary retrograde transport#GO:0035721;microtubule-based movement#GO:0007018;cell projection organization#GO:0030030;cellular component organization#GO:0016043;cilium assembly#GO:0060271 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;microtubule associated complex#GO:0005875;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;cytoplasmic dynein complex#GO:0005868;dynein complex#GO:0030286 microtubule or microtubule-binding cytoskeletal protein#PC00157 Huntington disease#P00029>Dynein complex#P00774 HUMAN|HGNC=14915|UniProtKB=Q9NYW2 Q9NYW2 TAS2R8 PTHR11394:SF31 TASTE RECEPTOR TYPE 2 TASTE RECEPTOR TYPE 2 MEMBER 8 taste receptor activity#GO:0008527;signaling receptor activity#GO:0038023;bitter taste receptor activity#GO:0033038;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;sensory perception of bitter taste#GO:0050913;detection of chemical stimulus#GO:0009593;response to chemical#GO:0042221;response to stimulus#GO:0050896;multicellular organismal process#GO:0032501;sensory perception of taste#GO:0050909;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;sensory perception#GO:0007600;detection of chemical stimulus involved in sensory perception of taste#GO:0050912;nervous system process#GO:0050877;detection of chemical stimulus involved in sensory perception of bitter taste#GO:0001580;system process#GO:0003008 membrane#GO:0016020;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=23030|UniProtKB=Q8N8U2 Q8N8U2 CDYL2 PTHR43684:SF2 FAMILY NOT NAMED CHROMODOMAIN Y-LIKE PROTEIN 2 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;catalytic activity#GO:0003824;transcription corepressor activity#GO:0003714;isomerase activity#GO:0016853;intramolecular oxidoreductase activity#GO:0016860 catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;small molecule catabolic process#GO:0044282;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;lipid oxidation#GO:0034440;fatty acid catabolic process#GO:0009062;oxoacid metabolic process#GO:0043436;monocarboxylic acid catabolic process#GO:0072329;cellular process#GO:0009987;lipid catabolic process#GO:0016042;carboxylic acid catabolic process#GO:0046395;lipid modification#GO:0030258;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;fatty acid beta-oxidation#GO:0006635;fatty acid oxidation#GO:0019395 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;peroxisomal matrix#GO:0005782;intracellular anatomical structure#GO:0005622;microbody#GO:0042579;nucleus#GO:0005634;peroxisome#GO:0005777;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=11123|UniProtKB=P52788 P52788 SMS PTHR46315:SF2 SPERMINE SYNTHASE SPERMINE SYNTHASE transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765 polyamine metabolic process#GO:0006595;cellular process#GO:0009987;metabolic process#GO:0008152;amine metabolic process#GO:0009308;biogenic amine metabolic process#GO:0006576;biosynthetic process#GO:0009058;polyamine biosynthetic process#GO:0006596 HUMAN|HGNC=5200|UniProtKB=Q9Y661 Q9Y661 HS3ST4 PTHR10605:SF11 HEPARAN SULFATE SULFOTRANSFERASE HEPARAN SULFATE GLUCOSAMINE 3-O-SULFOTRANSFERASE 4 transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring sulphur-containing groups#GO:0016782;sulfotransferase activity#GO:0008146 transferase#PC00220;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=9804|UniProtKB=Q9H0H5 Q9H0H5 RACGAP1 PTHR46199:SF3 RAC GTPASE-ACTIVATING PROTEIN 1 RAC GTPASE-ACTIVATING PROTEIN 1 molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;enzyme activator activity#GO:0008047 Rho protein signal transduction#GO:0007266;cytoskeleton-dependent cytokinesis#GO:0061640;nuclear division#GO:0000280;cytokinesis#GO:0000910;mitotic spindle organization#GO:0007052;response to stimulus#GO:0050896;signaling#GO:0023052;sister chromatid segregation#GO:0000819;nuclear chromosome segregation#GO:0098813;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;mitotic nuclear division#GO:0140014;cell cycle process#GO:0022402;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;chromosome segregation#GO:0007059;cellular component assembly#GO:0022607;spindle elongation#GO:0051231;intracellular signaling cassette#GO:0141124;cytoskeleton organization#GO:0007010;spindle assembly#GO:0051225;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;signal transduction#GO:0007165;organelle fission#GO:0048285;microtubule cytoskeleton organization#GO:0000226;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;organelle assembly#GO:0070925;mitotic cytokinesis#GO:0000281;regulation of cellular process#GO:0050794;mitotic cell cycle#GO:0000278;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cell cycle#GO:0007049;cellular response to stimulus#GO:0051716;cell division#GO:0051301;spindle organization#GO:0007051;chromosome organization#GO:0051276;mitotic cell cycle process#GO:1903047;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;mitotic sister chromatid segregation#GO:0000070;mitotic spindle assembly#GO:0090307 microtubule cytoskeleton#GO:0015630;membrane#GO:0016020;cell periphery#GO:0071944;nucleus#GO:0005634;plasma membrane region#GO:0098590;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;cell division site#GO:0032153;intracellular membraneless organelle#GO:0043232;spindle#GO:0005819;cytoskeleton#GO:0005856;cleavage furrow#GO:0032154;membraneless organelle#GO:0043228;intracellular protein-containing complex#GO:0140535;midbody#GO:0030496;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitotic spindle#GO:0072686;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;spindle midzone#GO:0051233;intracellular anatomical structure#GO:0005622 G-protein modulator#PC00022;GTPase-activating protein#PC00257 HUMAN|HGNC=26683|UniProtKB=Q8N9Z9 Q8N9Z9 LMNTD1 PTHR47012:SF1 LAMIN TAIL DOMAIN-CONTAINING PROTEIN 1 LAMIN TAIL DOMAIN-CONTAINING PROTEIN 1 nuclear envelope#GO:0005635;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;nucleus#GO:0005634;organelle envelope#GO:0031967;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=6880|UniProtKB=Q13164 Q13164 MAPK7 PTHR24055:SF561 MITOGEN-ACTIVATED PROTEIN KINASE MITOGEN-ACTIVATED PROTEIN KINASE 7 phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 non-receptor serine/threonine protein kinase#PC00167 Parkinson disease#P00049>ERK#P01211;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>MAPK#P00835;CCKR signaling map#P06959>MAPK7#P07021;Interferon-gamma signaling pathway#P00035>Serine kinase#P00955;Interleukin signaling pathway#P00036>ERK#P00965;TGF-beta signaling pathway#P00052>p42/p44MAPKs#P01293;Alzheimer disease-amyloid secretase pathway#P00003>MAPK#P00099;Endothelin signaling pathway#P00019>ERK#P00566;EGF receptor signaling pathway#P00018>ERK1-2#P00543;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>ERK#P00889;Apoptosis signaling pathway#P00006>MAPK#P00269;FGF signaling pathway#P00021>ERK1-2#P00627;PDGF signaling pathway#P00047>ERK#P01143 HUMAN|HGNC=10025|UniProtKB=Q13129 Q13129 RLF PTHR15507:SF18 ZINC FINGER PROTEIN RLF ZINC FINGER PROTEIN RLF DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=27158|UniProtKB=A8MPS7 A8MPS7 YDJC PTHR31609:SF1 YDJC DEACETYLASE FAMILY MEMBER CARBOHYDRATE DEACETYLASE deacetylase activity#GO:0019213;catalytic activity#GO:0003824;deacylase activity#GO:0160215 HUMAN|HGNC=5970|UniProtKB=P29460 P29460 IL12B PTHR48485:SF4 INTERLEUKIN-12 SUBUNIT BETA-RELATED INTERLEUKIN-12 SUBUNIT BETA cytokine receptor binding#GO:0005126;signaling receptor binding#GO:0005102;binding#GO:0005488;cytokine activity#GO:0005125;protein binding#GO:0005515;molecular function activator activity#GO:0140677;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;growth factor receptor binding#GO:0070851;cytokine binding#GO:0019955;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546 cell surface receptor signaling pathway#GO:0007166;cytokine-mediated signaling pathway#GO:0019221;response to peptide#GO:1901652;cell communication#GO:0007154;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;response to chemical#GO:0042221;response to cytokine#GO:0034097;regulation of cellular process#GO:0050794 extracellular region#GO:0005576;extracellular protein-containing complex#GO:0140392;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 HUMAN|HGNC=24074|UniProtKB=Q5VWM4 Q5VWM4 PRAMEF8 PTHR14224:SF30 SIMILAR TO PREFERENTIALLY EXPRESSED ANTIGEN IN MELANOMA-LIKE 3 PRAME FAMILY MEMBER 7-RELATED ubiquitin-like ligase-substrate adaptor activity#GO:1990756;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;enzyme-substrate adaptor activity#GO:0140767 proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152 intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;ubiquitin ligase complex#GO:0000151;transferase complex#GO:1990234;catalytic complex#GO:1902494;Cul2-RING ubiquitin ligase complex#GO:0031462;cullin-RING ubiquitin ligase complex#GO:0031461;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 HUMAN|HGNC=26967|UniProtKB=Q8IXR9 Q8IXR9 C12orf56 PTHR35354:SF1 RGD1561648 SIMILAR TO HUMAN CHROMOSOME 12 OPEN READING FRAME 56 HUMAN|HGNC=304|UniProtKB=P54107 P54107 CRISP1 PTHR10334:SF213 CYSTEINE-RICH SECRETORY PROTEIN-RELATED CYSTEINE-RICH SECRETORY PROTEIN 1 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090 HUMAN|HGNC=430|UniProtKB=O75342 O75342 ALOX12B PTHR11771:SF40 LIPOXYGENASE ARACHIDONATE 12-LIPOXYGENASE, 12R-TYPE catalytic activity#GO:0003824;dioxygenase activity#GO:0051213;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen#GO:0016702 lipid modification#GO:0030258;monocarboxylic acid biosynthetic process#GO:0072330;unsaturated fatty acid metabolic process#GO:0033559;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;biosynthetic process#GO:0009058;fatty acid biosynthetic process#GO:0006633;icosanoid metabolic process#GO:0006690;lipid biosynthetic process#GO:0008610;cellular process#GO:0009987;long-chain fatty acid metabolic process#GO:0001676;lipid oxidation#GO:0034440;oxoacid metabolic process#GO:0043436;olefinic compound metabolic process#GO:0120254;small molecule metabolic process#GO:0044281;arachidonate metabolic process#GO:0019369;carboxylic acid biosynthetic process#GO:0046394;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;perinuclear region of cytoplasm#GO:0048471;cellular anatomical structure#GO:0110165 oxygenase#PC00177;oxidoreductase#PC00176 HUMAN|HGNC=26648|UniProtKB=Q6ZW61 Q6ZW61 BBS12 PTHR46883:SF1 BARDET-BIEDL SYNDROME 12 PROTEIN CHAPERONIN-CONTAINING T-COMPLEX MEMBER BBS12 HUMAN|HGNC=6057|UniProtKB=Q16352 Q16352 INA PTHR45652:SF18 GLIAL FIBRILLARY ACIDIC PROTEIN ALPHA-INTERNEXIN structural constituent of synapse#GO:0098918;structural molecule activity#GO:0005198;structural constituent of cytoskeleton#GO:0005200 cytoskeleton organization#GO:0007010;intermediate filament cytoskeleton organization#GO:0045104;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;supramolecular fiber organization#GO:0097435;cellular component organization or biogenesis#GO:0071840;intermediate filament organization#GO:0045109;intermediate filament-based process#GO:0045103 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;postsynapse#GO:0098794;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoskeleton#GO:0005856;intermediate filament#GO:0005882;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cell junction#GO:0030054;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080 intermediate filament#PC00129;cytoskeletal protein#PC00085 HUMAN|HGNC=5012|UniProtKB=O75330 O75330 HMMR PTHR18956:SF6 HYALURONAN MEDIATED MOTILITY RECEPTOR HYALURONAN MEDIATED MOTILITY RECEPTOR HUMAN|HGNC=21213|UniProtKB=Q5TH69 Q5TH69 ARFGEF3 PTHR10663:SF344 GUANYL-NUCLEOTIDE EXCHANGE FACTOR BREFELDIN A-INHIBITED GUANINE NUCLEOTIDE-EXCHANGE PROTEIN 3 guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=2769|UniProtKB=O43583 O43583 DENR PTHR12789:SF0 DENSITY-REGULATED PROTEIN HOMOLOG DENSITY-REGULATED PROTEIN protein-containing complex binding#GO:0044877;ribosome binding#GO:0043022;ribonucleoprotein complex binding#GO:0043021;binding#GO:0005488 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;cytoplasmic translation#GO:0002181;translational initiation#GO:0006413;translation#GO:0006412;metabolic process#GO:0008152;cytoplasmic translational initiation#GO:0002183;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 translation initiation factor#PC00224 HUMAN|HGNC=13010|UniProtKB=Q9NRE2 Q9NRE2 TSHZ2 PTHR12487:SF3 TEASHIRT-RELATED TEASHIRT HOMOLOG 2 nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=8114|UniProtKB=Q5BJF6 Q5BJF6 ODF2 PTHR23162:SF8 OUTER DENSE FIBER OF SPERM TAILS 2 OUTER DENSE FIBER PROTEIN 2 regulation of plasma membrane bounded cell projection assembly#GO:0120032;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of cellular component biogenesis#GO:0044087;regulation of organelle assembly#GO:1902115;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of cell projection assembly#GO:0060491;regulation of cell projection organization#GO:0031344;regulation of cilium assembly#GO:1902017 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;centrosome#GO:0005813;microtubule organizing center#GO:0005815;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630 HUMAN|HGNC=3211|UniProtKB=P29692 P29692 EEF1D PTHR11595:SF21 EF-HAND AND COILED-COIL DOMAIN-CONTAINING FAMILY MEMBER ELONGATION FACTOR 1-DELTA enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;biosynthetic process#GO:0009058;metabolic process#GO:0008152;translational elongation#GO:0006414;translation#GO:0006412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 translation elongation factor#PC00222 HUMAN|HGNC=19409|UniProtKB=O43300 O43300 LRRTM2 PTHR45712:SF19 AGAP008170-PA LEUCINE-RICH REPEAT TRANSMEMBRANE NEURONAL PROTEIN 2 HUMAN|HGNC=12237|UniProtKB=A0A075B6L6 A0A075B6L6 TRBV7-3 PTHR23268:SF105 T-CELL RECEPTOR BETA CHAIN NON-FUNCTIONAL T CELL RECEPTOR BETA VARIABLE 7-3-RELATED cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=25901|UniProtKB=Q8N4X5 Q8N4X5 AFAP1L2 PTHR14338:SF4 ACTIN FILAMENT-ASSOCIATED PROTEIN 1 FAMILY MEMBER ACTIN FILAMENT-ASSOCIATED PROTEIN 1-LIKE 2 enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;kinase activator activity#GO:0019209;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;protein kinase regulator activity#GO:0019887;enzyme activator activity#GO:0008047;protein kinase activator activity#GO:0030295 response to stimulus#GO:0050896;regulation of cell cycle#GO:0051726;regulation of biological process#GO:0050789;positive regulation of signaling#GO:0023056;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of signaling#GO:0023051;positive regulation of macromolecule metabolic process#GO:0010604;response to stress#GO:0006950;positive regulation of biological process#GO:0048518;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;regulation of cell communication#GO:0010646;positive regulation of signal transduction#GO:0009967;regulation of ERBB signaling pathway#GO:1901184;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;inflammatory response#GO:0006954;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of response to stimulus#GO:0048584;regulation of epidermal growth factor receptor signaling pathway#GO:0042058;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of signal transduction#GO:0009966;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of mitotic cell cycle#GO:0007346;positive regulation of cellular process#GO:0048522;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;defense response#GO:0006952;regulation of response to stimulus#GO:0048583 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=12692|UniProtKB=P08670 P08670 VIM PTHR45652:SF5 GLIAL FIBRILLARY ACIDIC PROTEIN VIMENTIN structural constituent of cytoskeleton#GO:0005200;structural molecule activity#GO:0005198 supramolecular fiber organization#GO:0097435;cellular component organization or biogenesis#GO:0071840;intermediate filament organization#GO:0045109;intermediate filament-based process#GO:0045103;cytoskeleton organization#GO:0007010;intermediate filament cytoskeleton organization#GO:0045104;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996 supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;intermediate filament#GO:0005882;cytoskeleton#GO:0005856;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;axon#GO:0030424;intracellular organelle#GO:0043229 intermediate filament#PC00129;cytoskeletal protein#PC00085 HUMAN|HGNC=33706|UniProtKB=A6NMZ2 A6NMZ2 SNTN PTHR11639:SF134 S100 CALCIUM-BINDING PROTEIN SENTAN calmodulin-related#PC00061;calcium-binding protein#PC00060 HUMAN|HGNC=28671|UniProtKB=Q86UE3 Q86UE3 ZNF546 PTHR24377:SF142 IP01015P-RELATED ZINC FINGER PROTEIN 546 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=654|UniProtKB=P61204 P61204 ARF3 PTHR11711:SF422 ADP RIBOSYLATION FACTOR-RELATED ADP-RIBOSYLATION FACTOR 3 heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;nucleotide binding#GO:0000166;carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;ribonucleotide binding#GO:0032553;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;small molecule binding#GO:0036094;anion binding#GO:0043168;guanyl nucleotide binding#GO:0019001 vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;macromolecule localization#GO:0033036;intracellular protein localization#GO:0008104;protein transport#GO:0015031;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 G-protein#PC00020 Huntington disease#P00029>ARF#P00786;Integrin signalling pathway#P00034>Arf1#P00923 HUMAN|HGNC=24015|UniProtKB=Q7Z4G1 Q7Z4G1 COMMD6 PTHR16231:SF5 COMM DOMAIN-CONTAINING PROTEIN 4-8 FAMILY MEMBER COMM DOMAIN-CONTAINING PROTEIN 6 structural molecule activity#GO:0005198;protein complex scaffold activity#GO:0140378 response to tumor necrosis factor#GO:0034612;cellular process#GO:0009987;signal transduction#GO:0007165;response to cytokine#GO:0034097;response to chemical#GO:0042221;biological regulation#GO:0065007;cell surface receptor signaling pathway#GO:0007166;cellular response to stimulus#GO:0051716;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;cytokine-mediated signaling pathway#GO:0019221;tumor necrosis factor-mediated signaling pathway#GO:0033209;cell communication#GO:0007154;response to peptide#GO:1901652 protein-containing complex#GO:0032991 HUMAN|HGNC=20772|UniProtKB=Q13509 Q13509 TUBB3 PTHR11588:SF43 TUBULIN TUBULIN BETA-3 CHAIN purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;structural constituent of cytoskeleton#GO:0005200;binding#GO:0005488;nucleoside phosphate binding#GO:1901265;guanyl nucleotide binding#GO:0019001;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;structural molecule activity#GO:0005198;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;anion binding#GO:0043168;ion binding#GO:0043167 cytoskeleton organization#GO:0007010;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;neuron projection development#GO:0031175;organelle organization#GO:0006996;cellular process#GO:0009987;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cell projection morphogenesis#GO:0048858;microtubule-based process#GO:0007017;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell morphogenesis#GO:0000902;cell development#GO:0048468;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;neuron development#GO:0048666;axonogenesis#GO:0007409;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;axon development#GO:0061564;axon guidance#GO:0007411;cellular developmental process#GO:0048869;neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;mitotic cell cycle#GO:0000278;cell cycle#GO:0007049;microtubule cytoskeleton organization#GO:0000226;anatomical structure development#GO:0048856;system development#GO:0048731 intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;microtubule#GO:0005874;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;supramolecular complex#GO:0099080;organelle#GO:0043226;microtubule cytoskeleton#GO:0015630 cytoskeletal protein#PC00085;tubulin#PC00228 Huntington disease#P00029>beta-Tubulin#P00790;Cytoskeletal regulation by Rho GTPase#P00016>tubulin#P00526;Huntington disease#P00029>Microtubule#P00780 HUMAN|HGNC=16993|UniProtKB=P60468 P60468 SEC61B PTHR13509:SF26 SEC61 SUBUNIT BETA PROTEIN TRANSPORT PROTEIN SEC61 SUBUNIT BETA enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 post-translational protein targeting to membrane, translocation#GO:0031204;protein transport#GO:0015031;localization#GO:0051179;cellular localization#GO:0051641;transmembrane transport#GO:0055085;localization within membrane#GO:0051668;post-translational protein targeting to endoplasmic reticulum membrane#GO:0006620;protein targeting#GO:0006605;intracellular protein localization#GO:0008104;protein targeting to ER#GO:0045047;establishment of protein localization to organelle#GO:0072594;intracellular protein transmembrane transport#GO:0065002;establishment of localization#GO:0051234;transport#GO:0006810;SRP-dependent cotranslational protein targeting to membrane#GO:0006614;intracellular protein transport#GO:0006886;protein transmembrane transport#GO:0071806;protein targeting to membrane#GO:0006612;intracellular transport#GO:0046907;establishment of protein localization to endoplasmic reticulum#GO:0072599;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;establishment of protein localization to membrane#GO:0090150;macromolecule localization#GO:0033036 membrane#GO:0016020;cytoplasm#GO:0005737;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum protein-containing complex#GO:0140534;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;rough endoplasmic reticulum membrane#GO:0030867;rough endoplasmic reticulum#GO:0005791 membrane traffic protein#PC00150 HUMAN|HGNC=24027|UniProtKB=Q8TDG2 Q8TDG2 ACTRT1 PTHR11937:SF153 ACTIN ACTIN-RELATED PROTEIN T1 chromatin binding#GO:0003682;structural constituent of cytoskeleton#GO:0005200;binding#GO:0005488;structural molecule activity#GO:0005198 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;nucleus#GO:0005634;actin cytoskeleton#GO:0015629;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 actin and actin related protein#PC00039 HUMAN|HGNC=24351|UniProtKB=Q9P1Y6 Q9P1Y6 PHRF1 PTHR12618:SF20 PHD AND RING FINGER DOMAIN-CONTAINING PROTEIN 1 PHD AND RING FINGER DOMAIN-CONTAINING PROTEIN 1 HUMAN|HGNC=12870|UniProtKB=P08048 P08048 ZFY PTHR24408:SF25 ZINC FINGER PROTEIN ZINC FINGER Y-CHROMOSOMAL PROTEIN DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=14076|UniProtKB=Q96G23 Q96G23 CERS2 PTHR12560:SF7 LONGEVITY ASSURANCE FACTOR 1 LAG1 CERAMIDE SYNTHASE 2 acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 lipid metabolic process#GO:0006629;ceramide biosynthetic process#GO:0046513;sphingolipid biosynthetic process#GO:0030148;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;ceramide metabolic process#GO:0006672;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;transferase#PC00220 HUMAN|HGNC=29933|UniProtKB=Q86WI3 Q86WI3 NLRC5 PTHR24106:SF281 NACHT, LRR AND CARD DOMAINS-CONTAINING PROTEIN NLRC5 molecular function inhibitor activity#GO:0140678;molecular function regulator activity#GO:0098772 regulation of innate immune response#GO:0045088;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;regulation of response to stress#GO:0080134;negative regulation of immune system process#GO:0002683;negative regulation of response to external stimulus#GO:0032102;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of signal transduction#GO:0009968;negative regulation of innate immune response#GO:0045824;negative regulation of response to stimulus#GO:0048585;regulation of response to external stimulus#GO:0032101;regulation of canonical NF-kappaB signal transduction#GO:0043122;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;regulation of immune response#GO:0050776;negative regulation of immune response#GO:0050777;regulation of defense response#GO:0031347;regulation of signaling#GO:0023051;regulation of inflammatory response#GO:0050727;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;regulation of response to biotic stimulus#GO:0002831;regulation of cell communication#GO:0010646;negative regulation of canonical NF-kappaB signal transduction#GO:0043124;regulation of immune system process#GO:0002682;negative regulation of inflammatory response#GO:0050728;negative regulation of defense response#GO:0031348;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 scaffold/adaptor protein#PC00226 HUMAN|HGNC=44404|UniProtKB=H3BSY2 H3BSY2 GOLGA8M PTHR10881:SF62 GOLGIN SUBFAMILY A MEMBER-RELATED GOLGIN SUBFAMILY A CONSERVED DOMAIN-CONTAINING PROTEIN-RELATED endomembrane system organization#GO:0010256;cellular component organization or biogenesis#GO:0071840;Golgi organization#GO:0007030;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043 endomembrane system#GO:0012505;Golgi cisterna#GO:0031985;cytoplasm#GO:0005737;Golgi cis cisterna#GO:0000137;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;organelle membrane#GO:0031090;cis-Golgi network#GO:0005801;Golgi apparatus#GO:0005794;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;Golgi stack#GO:0005795;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular organelle#GO:0043229 membrane traffic protein#PC00150 HUMAN|HGNC=4620|UniProtKB=P06396 P06396 GSN PTHR11977:SF29 VILLIN GELSOLIN cytoskeletal protein binding#GO:0008092;phospholipid binding#GO:0005543;phosphatidylinositol phosphate binding#GO:1901981;actin binding#GO:0003779;actin filament binding#GO:0051015;anion binding#GO:0043168;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;phosphatidylinositol-4,5-bisphosphate binding#GO:0005546;protein-containing complex binding#GO:0044877;lipid binding#GO:0008289;protein binding#GO:0005515;phosphatidylinositol bisphosphate binding#GO:1902936 regulation of anatomical structure size#GO:0090066;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cellular process#GO:0009987;cell projection assembly#GO:0030031;regulation of protein-containing complex disassembly#GO:0043244;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;nervous system development#GO:0007399;regulation of actin cytoskeleton organization#GO:0032956;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;regulation of actin filament length#GO:0030832;animal gross anatomical part developmental process#GO:0160108;negative regulation of actin filament depolymerization#GO:0030835;regulation of biological quality#GO:0065008;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of cellular component size#GO:0032535;regulation of protein-containing complex assembly#GO:0043254;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;regulation of cellular component biogenesis#GO:0044087;negative regulation of actin filament polymerization#GO:0030837;central nervous system development#GO:0007417;regulation of cellular component organization#GO:0051128;cell projection organization#GO:0030030;developmental process#GO:0032502;regulation of actin filament-based process#GO:0032970;negative regulation of cellular process#GO:0048523;regulation of protein depolymerization#GO:1901879;actin filament organization#GO:0007015;actin polymerization or depolymerization#GO:0008154;regulation of actin filament organization#GO:0110053;negative regulation of protein depolymerization#GO:1901880;regulation of actin polymerization or depolymerization#GO:0008064;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regulation of actin filament polymerization#GO:0030833;actin filament-based process#GO:0030029;negative regulation of protein polymerization#GO:0032272;actin filament capping#GO:0051693;negative regulation of protein-containing complex assembly#GO:0031333;system development#GO:0048731;supramolecular fiber organization#GO:0097435;anatomical structure development#GO:0048856;negative regulation of protein-containing complex disassembly#GO:0043242;negative regulation of cytoskeleton organization#GO:0051494;regulation of supramolecular fiber organization#GO:1902903;negative regulation of organelle organization#GO:0010639;negative regulation of cellular component organization#GO:0051129;regulation of actin filament depolymerization#GO:0030834;regulation of cellular process#GO:0050794;actin cytoskeleton organization#GO:0030036;negative regulation of supramolecular fiber organization#GO:1902904;regulation of cytoskeleton organization#GO:0051493;regulation of protein polymerization#GO:0032271 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;actin cytoskeleton#GO:0015629;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;extracellular region#GO:0005576 actin or actin-binding cytoskeletal protein#PC00041;non-motor actin binding protein#PC00165 FAS signaling pathway#P00020>Gelsolin#P00611 HUMAN|HGNC=23412|UniProtKB=Q5VSP4 Q5VSP4 LCN1P1 PTHR11430:SF124 LIPOCALIN LIPOCALIN 1-LIKE PROTEIN 1-RELATED cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 transfer/carrier protein#PC00219 HUMAN|HGNC=20872|UniProtKB=Q969F1 Q969F1 GTF3C6 PTHR21860:SF2 TRANSCRIPTION INITIATION FACTOR IIIC TFIIIC , POLYPEPTIDE 6-RELATED GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 6 RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;nucleic acid biosynthetic process#GO:0141187;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;DNA-templated transcription#GO:0006351;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA biosynthetic process#GO:0032774;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;transcription by RNA polymerase III#GO:0006383;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 transcription factor TFIIIC complex#GO:0000127;protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667 HUMAN|HGNC=1297|UniProtKB=Q9NX36 Q9NX36 DNAJC28 PTHR39158:SF2 OS08G0560600 PROTEIN DNAJ HOMOLOG SUBFAMILY C MEMBER 28 homeostatic process#GO:0042592;multicellular organismal-level homeostasis#GO:0048871;multicellular organismal process#GO:0032501;temperature homeostasis#GO:0001659 HUMAN|HGNC=2649|UniProtKB=Q16850 Q16850 CYP51A1 PTHR24286:SF191 CYTOCHROME P450 26 LANOSTEROL 14-ALPHA DEMETHYLASE oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen#GO:0016712;demethylase activity#GO:0032451;oxidoreductase activity#GO:0016491;monooxygenase activity#GO:0004497;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705 secondary alcohol metabolic process#GO:1902652;small molecule metabolic process#GO:0044281;primary metabolic process#GO:0044238;sterol biosynthetic process#GO:0016126;biosynthetic process#GO:0009058;steroid metabolic process#GO:0008202;lipid biosynthetic process#GO:0008610;cholesterol biosynthetic process#GO:0006695;cellular process#GO:0009987;alcohol biosynthetic process#GO:0046165;sterol metabolic process#GO:0016125;steroid biosynthetic process#GO:0006694;secondary alcohol biosynthetic process#GO:1902653;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;cholesterol metabolic process#GO:0008203;alcohol metabolic process#GO:0006066;metabolic process#GO:0008152 oxygenase#PC00177 HUMAN|HGNC=13760|UniProtKB=Q96F07 Q96F07 CYFIP2 PTHR12195:SF5 CYTOPLASMIC FMR1-INTERACTING PROTEIN-RELATED CYTOPLASMIC FMR1-INTERACTING PROTEIN 2 multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;axon development#GO:0061564;regulation of macromolecule biosynthetic process#GO:0010556;axon guidance#GO:0007411;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;neuron projection guidance#GO:0097485;post-transcriptional regulation of gene expression#GO:0010608;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;programmed cell death#GO:0012501;cell death#GO:0008219;anatomical structure development#GO:0048856;system development#GO:0048731;cellular component assembly#GO:0022607;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;regulation of protein metabolic process#GO:0051246;neuron projection development#GO:0031175;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cell projection assembly#GO:0030031;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cell projection morphogenesis#GO:0048858;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell development#GO:0048468;cellular component organization#GO:0016043;apoptotic process#GO:0006915;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;axonogenesis#GO:0007409;neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699 cell junction#GO:0030054;intracellular anatomical structure#GO:0005622;neuron projection#GO:0043005;cellular anatomical structure#GO:0110165;synapse#GO:0045202;protein-containing complex#GO:0032991;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737 scaffold/adaptor protein#PC00226 Huntington disease#P00029>p53#P00797 HUMAN|HGNC=28684|UniProtKB=Q8N587 Q8N587 ZNF561 PTHR24377:SF1031 IP01015P-RELATED ZINC FINGER PROTEIN 561 binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=26902|UniProtKB=Q8NC24 Q8NC24 RELL2 PTHR31481:SF0 RELT-LIKE PROTEIN 2 RELL2 RELT-LIKE PROTEIN 2 positive regulation of signaling#GO:0023056;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of cell communication#GO:0010646;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789;positive regulation of cell adhesion#GO:0045785;positive regulation of cell-substrate adhesion#GO:0010811;positive regulation of MAPK cascade#GO:0043410;positive regulation of intracellular signal transduction#GO:1902533;regulation of MAPK cascade#GO:0043408;regulation of response to stimulus#GO:0048583;positive regulation of response to stimulus#GO:0048584;regulation of cell adhesion#GO:0030155;biological regulation#GO:0065007;regulation of cell-substrate adhesion#GO:0010810;regulation of signal transduction#GO:0009966;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522 HUMAN|HGNC=16066|UniProtKB=Q9NUN7 Q9NUN7 ACER3 PTHR46187:SF3 ALKALINE CERAMIDASE 3 ALKALINE CERAMIDASE 3 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811 sphingoid biosynthetic process#GO:0046520;alcohol metabolic process#GO:0006066;sphingolipid biosynthetic process#GO:0030148;metabolic process#GO:0008152;sphingolipid metabolic process#GO:0006665;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;lipid biosynthetic process#GO:0008610;small molecule metabolic process#GO:0044281;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;alcohol biosynthetic process#GO:0046165 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827 HUMAN|HGNC=48327|UniProtKB=H3BUK9 H3BUK9 POTEB2 PTHR24118:SF65 POTE ANKYRIN DOMAIN POTE ANKYRIN DOMAIN FAMILY MEMBER B-RELATED transcription regulator activity#GO:0140110;transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712 regulation of non-canonical NF-kappaB signal transduction#GO:1901222;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;regulation of intracellular signal transduction#GO:1902531;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535 membrane traffic protein#PC00150 HUMAN|HGNC=6648|UniProtKB=Q6P5Q4 Q6P5Q4 LMOD2 PTHR10901:SF12 TROPOMODULIN LEIOMODIN-2 protein binding#GO:0005515;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779 multicellular organismal process#GO:0032501;actin filament organization#GO:0007015;system process#GO:0003008;cellular developmental process#GO:0048869;developmental process#GO:0032502;muscle contraction#GO:0006936;actin cytoskeleton organization#GO:0030036;muscle structure development#GO:0061061;myofibril assembly#GO:0030239;muscle cell differentiation#GO:0042692;muscle cell development#GO:0055001;supramolecular fiber organization#GO:0097435;anatomical structure development#GO:0048856;actin filament-based process#GO:0030029;organelle assembly#GO:0070925;cellular component assembly involved in morphogenesis#GO:0010927;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;anatomical structure formation involved in morphogenesis#GO:0048646;striated muscle cell differentiation#GO:0051146;cellular component organization or biogenesis#GO:0071840;cellular anatomical entity morphogenesis#GO:0032989;actomyosin structure organization#GO:0031032;cell development#GO:0048468;cell differentiation#GO:0030154;muscle system process#GO:0003012;anatomical structure morphogenesis#GO:0009653;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;striated muscle cell development#GO:0055002;animal gross anatomical part developmental process#GO:0160108 A band#GO:0031672;actin cytoskeleton#GO:0015629;cellular anatomical structure#GO:0110165;organelle#GO:0043226;M band#GO:0031430;intracellular organelle#GO:0043229;myofibril#GO:0030016;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;contractile muscle fiber#GO:0043292;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;sarcomere#GO:0030017 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=3595|UniProtKB=Q14517 Q14517 FAT1 PTHR24026:SF42 FAT ATYPICAL CADHERIN-RELATED PROTOCADHERIN FAT 1 cell-cell adhesion#GO:0098609;cell adhesion#GO:0007155;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;cell junction#GO:0030054;anchoring junction#GO:0070161;adherens junction#GO:0005912;cell-cell junction#GO:0005911 cadherin#PC00057 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HUMAN|HGNC=6594|UniProtKB=P50458 P50458 LHX2 PTHR24208:SF80 LIM/HOMEOBOX PROTEIN LHX LIM_HOMEOBOX PROTEIN LHX2 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;developmental process#GO:0032502;neuron differentiation#GO:0030182;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;multicellular organism development#GO:0007275;cellular process#GO:0009987;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;nervous system development#GO:0007399;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119 Gonadotropin-releasing hormone receptor pathway#P06664>LHX2#P06756 HUMAN|HGNC=24678|UniProtKB=Q9C0B1 Q9C0B1 FTO PTHR31291:SF2 ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE FTO ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE FTO regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cellular response to stress#GO:0033554;RNA metabolic process#GO:0016070;cellular process#GO:0009987;response to stress#GO:0006950;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;DNA damage response#GO:0006974;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;macromolecule metabolic process#GO:0043170 oxidoreductase#PC00176;oxygenase#PC00177 HUMAN|HGNC=31452|UniProtKB=Q8IV03 Q8IV03 LURAP1L PTHR33767:SF1 LEUCINE RICH ADAPTOR PROTEIN 1-LIKE LEUCINE RICH ADAPTOR PROTEIN 1-LIKE regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;regulation of biological process#GO:0050789;regulation of cell communication#GO:0010646;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cellular process#GO:0050794 HUMAN|HGNC=9656|UniProtKB=P29074 P29074 PTPN4 PTHR45706:SF7 TYROSINE-PROTEIN PHOSPHATASE TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 4 catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;protein tyrosine phosphatase activity#GO:0004725;hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721 cytoplasmic side of membrane#GO:0098562;side of membrane#GO:0098552;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;cytoplasmic side of plasma membrane#GO:0009898;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cytoplasm#GO:0005737 protein phosphatase#PC00195 HUMAN|Gene=YC006_HUMAN|UniProtKB=Q6ZUG5 Q6ZUG5 PTHR33667:SF7 SI:DKEY-57N24.6 CILIA AND FLAGELLA ASSOCIATED PROTEIN 92 HUMAN|HGNC=9909|UniProtKB=Q15434 Q15434 RBMS2 PTHR24012:SF786 RNA BINDING PROTEIN RNA-BINDING MOTIF, SINGLE-STRANDED-INTERACTING PROTEIN 2 binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 ribonucleoprotein complex#GO:1990904;protein-containing complex#GO:0032991 RNA metabolism protein#PC00031 HUMAN|HGNC=22995|UniProtKB=Q7Z5M5 Q7Z5M5 TMC3 PTHR23302:SF35 TRANSMEMBRANE CHANNEL-RELATED TRANSMEMBRANE CHANNEL-LIKE PROTEIN 3 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;gated channel activity#GO:0022836;passive transmembrane transporter activity#GO:0022803;channel activity#GO:0015267;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133 HUMAN|HGNC=11181|UniProtKB=P08294 P08294 SOD3 PTHR10003:SF77 SUPEROXIDE DISMUTASE CU-ZN -RELATED EXTRACELLULAR SUPEROXIDE DISMUTASE [CU-ZN] cation binding#GO:0043169;metal ion binding#GO:0046872;transition metal ion binding#GO:0046914;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;copper ion binding#GO:0005507;antioxidant activity#GO:0016209 response to toxic substance#GO:0009636;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular detoxification#GO:1990748;cellular response to stress#GO:0033554;response to oxygen-containing compound#GO:1901700;cellular response to chemical stimulus#GO:0070887;cellular response to toxic substance#GO:0097237;detoxification#GO:0098754;cellular response to oxidative stress#GO:0034599;response to chemical#GO:0042221;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;cellular oxidant detoxification#GO:0098869;response to stress#GO:0006950;response to reactive oxygen species#GO:0000302;superoxide metabolic process#GO:0006801;cellular response to chemical stress#GO:0062197;response to oxidative stress#GO:0006979;reactive oxygen species metabolic process#GO:0072593;metabolic process#GO:0008152 oxidoreductase#PC00176 HUMAN|HGNC=2637|UniProtKB=P08684 P08684 CYP3A4 PTHR24302:SF48 CYTOCHROME P450 FAMILY 3 CYTOCHROME P450 3A4 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen#GO:0016712;oxidoreductase activity#GO:0016491;monooxygenase activity#GO:0004497;steroid hydroxylase activity#GO:0008395;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705 metabolic process#GO:0008152;primary metabolic process#GO:0044238;lipid metabolic process#GO:0006629;cellular process#GO:0009987;steroid metabolic process#GO:0008202 oxygenase#PC00177;oxidoreductase#PC00176 HUMAN|HGNC=6705|UniProtKB=Q13449 Q13449 LSAMP PTHR42757:SF22 IGLON FAMILY OF IMMUNOGLOBULIN SUPERFAMILY-RELATED LIMBIC SYSTEM-ASSOCIATED MEMBRANE PROTEIN regulation of synapse structure or activity#GO:0050803;regulation of biological quality#GO:0065008;regulation of cell junction assembly#GO:1901888;regulation of synapse organization#GO:0050807;cell adhesion#GO:0007155;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of synapse assembly#GO:0051963;regulation of cellular component biogenesis#GO:0044087;biological regulation#GO:0065007;cell-cell adhesion#GO:0098609;cellular process#GO:0009987;heterophilic cell-cell adhesion#GO:0007157;regulation of biological process#GO:0050789 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 immunoglobulin#PC00123 HUMAN|HGNC=9069|UniProtKB=Q15149 Q15149 PLEC PTHR23169:SF20 ENVOPLAKIN PLECTIN protein binding#GO:0005515;structural molecule activity#GO:0005198;binding#GO:0005488;structural constituent of cytoskeleton#GO:0005200;cytoskeletal protein binding#GO:0008092 wound healing#GO:0042060;intermediate filament-based process#GO:0045103;response to stimulus#GO:0050896;intermediate filament cytoskeleton organization#GO:0045104;cell junction organization#GO:0034330;cell junction assembly#GO:0034329;cell-substrate junction assembly#GO:0007044;cellular component organization#GO:0016043;cellular component organization or biogenesis#GO:0071840;cell-substrate junction organization#GO:0150115;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;response to stress#GO:0006950;response to wounding#GO:0009611 supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;perinuclear region of cytoplasm#GO:0048471;cytoplasm#GO:0005737;membrane#GO:0016020;cell periphery#GO:0071944;sarcolemma#GO:0042383;cell junction#GO:0030054;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;intermediate filament#GO:0005882;cytoskeleton#GO:0005856;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell-substrate junction#GO:0030055;focal adhesion#GO:0005925;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;intracellular organelle#GO:0043229 intermediate filament binding protein#PC00130;intermediate filament#PC00129 HUMAN|HGNC=6454|UniProtKB=O76013 O76013 KRT36 PTHR23239:SF204 INTERMEDIATE FILAMENT KERATIN, TYPE I CUTICULAR HA6 structural molecule activity#GO:0005198 cellular process#GO:0009987;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;epithelium development#GO:0060429;epithelial cell differentiation#GO:0030855;tissue development#GO:0009888;developmental process#GO:0032502;morphogenesis of an epithelium#GO:0002009;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;intermediate filament cytoskeleton organization#GO:0045104;cell differentiation#GO:0030154;intermediate filament organization#GO:0045109;intermediate filament-based process#GO:0045103;animal gross anatomical part developmental process#GO:0160108;supramolecular fiber organization#GO:0097435;tissue morphogenesis#GO:0048729;anatomical structure development#GO:0048856 supramolecular complex#GO:0099080;organelle#GO:0043226;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;supramolecular fiber#GO:0099512;intermediate filament#GO:0005882;intracellular anatomical structure#GO:0005622 intermediate filament#PC00129 HUMAN|HGNC=8779|UniProtKB=Q13370 Q13370 PDE3B PTHR11347:SF29 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE PHOSPHODIESTERASE cyclic-nucleotide phosphodiesterase activity#GO:0004112;phosphoric diester hydrolase activity#GO:0008081;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;negative regulation of response to stimulus#GO:0048585;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of signal transduction#GO:0009968;regulation of cell communication#GO:0010646;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789 hydrolase#PC00121;phosphodiesterase#PC00185 HUMAN|HGNC=28906|UniProtKB=Q9NQR9 Q9NQR9 G6PC2 PTHR12591:SF1 GLUCOSE-6-PHOSPHATASE GLUCOSE-6-PHOSPHATASE 2 hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;sugar-phosphatase activity#GO:0050308;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787 small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152;monosaccharide metabolic process#GO:0005996;glucose metabolic process#GO:0006006;hexose biosynthetic process#GO:0019319;gluconeogenesis#GO:0006094;cellular process#GO:0009987;primary metabolic process#GO:0044238;hexose metabolic process#GO:0019318;biosynthetic process#GO:0009058;carbohydrate metabolic process#GO:0005975;monosaccharide biosynthetic process#GO:0046364;carbohydrate biosynthetic process#GO:0016051;small molecule metabolic process#GO:0044281 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 hydrolase#PC00121;phosphatase#PC00181 HUMAN|HGNC=29141|UniProtKB=O94967 O94967 WDR47 PTHR19863:SF5 NEMITIN (NEURONAL ENRICHED MAP INTERACTING PROTEIN) HOMOLOG WD REPEAT-CONTAINING PROTEIN 47 HUMAN|HGNC=11157|UniProtKB=P09234 P09234 SNRPC PTHR31148:SF1 U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;protein-containing complex organization#GO:0043933;protein-RNA complex organization#GO:0071826;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;mRNA processing#GO:0006397;mRNA splice site recognition#GO:0006376;RNA processing#GO:0006396;gene expression#GO:0010467;cellular component assembly#GO:0022607;spliceosomal complex assembly#GO:0000245;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;protein-containing complex assembly#GO:0065003;mRNA splicing, via spliceosome#GO:0000398;cellular component organization#GO:0016043;ribonucleoprotein complex biogenesis#GO:0022613;mRNA metabolic process#GO:0016071;mRNA cis splicing, via spliceosome#GO:0045292;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA splicing, via transesterification reactions#GO:0000375;protein-RNA complex assembly#GO:0022618;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774 small nuclear ribonucleoprotein complex#GO:0030532;nucleus#GO:0005634;organelle#GO:0043226;U1 snRNP#GO:0005685;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;spliceosomal snRNP complex#GO:0097525;nuclear protein-containing complex#GO:0140513;Sm-like protein family complex#GO:0120114;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=23846|UniProtKB=Q96BF6 Q96BF6 NACC2 PTHR46105:SF2 AGAP004733-PA NUCLEUS ACCUMBENS-ASSOCIATED PROTEIN 2 double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=20305|UniProtKB=Q8N130 Q8N130 SLC34A3 PTHR10010:SF35 SOLUTE CARRIER FAMILY 34 SODIUM PHOSPHATE , MEMBER 2-RELATED SODIUM-DEPENDENT PHOSPHATE TRANSPORT PROTEIN 2C phosphate transmembrane transporter activity#GO:0005315;symporter activity#GO:0015293;monoatomic cation transmembrane transporter activity#GO:0008324;solute:sodium symporter activity#GO:0015370;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;active transmembrane transporter activity#GO:0022804;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294 transport#GO:0006810;chemical homeostasis#GO:0048878;inorganic ion homeostasis#GO:0098771;inorganic anion transport#GO:0015698;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;localization#GO:0051179;establishment of localization#GO:0051234;homeostatic process#GO:0042592;phosphate ion transport#GO:0006817 apical part of cell#GO:0045177;cluster of actin-based cell projections#GO:0098862;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;apical plasma membrane#GO:0016324;cell periphery#GO:0071944;brush border#GO:0005903;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;organelle#GO:0043226;plasma membrane#GO:0005886 secondary carrier transporter#PC00258 HUMAN|HGNC=28287|UniProtKB=Q96F25 Q96F25 ALG14 PTHR12154:SF4 GLYCOSYL TRANSFERASE-RELATED UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG14 protein-membrane adaptor activity#GO:0043495;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;protein N-linked glycosylation#GO:0006487;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;biosynthetic process#GO:0009058 membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;endoplasmic reticulum protein-containing complex#GO:0140534;organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;transferase complex#GO:1990234;endoplasmic reticulum#GO:0005783;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;membrane#GO:0016020 transferase#PC00220 HUMAN|HGNC=29129|UniProtKB=O94919 O94919 ENDOD1 PTHR21472:SF8 ENDONUCLEASE DOMAIN-CONTAINING 1 PROTEIN ENDOD1 ENDONUCLEASE DOMAIN-CONTAINING 1 PROTEIN HUMAN|HGNC=5292|UniProtKB=P30939 P30939 HTR1F PTHR24247:SF34 5-HYDROXYTRYPTAMINE RECEPTOR 5-HYDROXYTRYPTAMINE RECEPTOR 1F signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;G protein-coupled amine receptor activity#GO:0008227;neurotransmitter receptor activity#GO:0030594 cell communication#GO:0007154;trans-synaptic signaling#GO:0099537;G protein-coupled receptor signaling pathway#GO:0007186;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;response to stimulus#GO:0050896;signaling#GO:0023052;chemical synaptic transmission#GO:0007268;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway#GO:0007193;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;synaptic signaling#GO:0099536;cellular process#GO:0009987;signal transduction#GO:0007165 cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;dendrite#GO:0030425;dendritic tree#GO:0097447 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GsPCR#P00720;5HT1 type receptor mediated signaling pathway#P04373>5HT1 Receptor#P04404 HUMAN|HGNC=11128|UniProtKB=O95863 O95863 SNAI1 PTHR24388:SF106 ZINC FINGER PROTEIN ZINC FINGER PROTEIN SNAI1 transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;DNA-binding transcription repressor activity#GO:0001217;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 CCKR signaling map#P06959>SNAI1#P07055 HUMAN|HGNC=19223|UniProtKB=P56851 P56851 EDDM3B PTHR16788:SF0 EPIDIDYMAL SECRETORY PROTEIN E3 ALPHA EPIDIDYMAL SECRETORY PROTEIN E3-BETA HUMAN|HGNC=6051|UniProtKB=O14732 O14732 IMPA2 PTHR20854:SF29 INOSITOL MONOPHOSPHATASE INOSITOL MONOPHOSPHATASE 2 phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824 biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;small molecule metabolic process#GO:0044281;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154;alcohol metabolic process#GO:0006066;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 phosphatase#PC00181 HUMAN|HGNC=428|UniProtKB=Q8TCU4 Q8TCU4 ALMS1 PTHR21553:SF22 ALMS1-RELATED CENTROSOME-ASSOCIATED PROTEIN ALMS1 regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of cell cycle#GO:0051726;regulation of cell cycle process#GO:0010564;biological regulation#GO:0065007;regulation of cellular component biogenesis#GO:0044087;regulation of biological process#GO:0050789;regulation of organelle assembly#GO:1902115;regulation of organelle organization#GO:0033043;regulation of microtubule-based process#GO:0032886 centriole#GO:0005814;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microtubule cytoskeleton#GO:0015630;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;centrosome#GO:0005813;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856 HUMAN|HGNC=26776|UniProtKB=Q6PIY7 Q6PIY7 TENT2 PTHR12271:SF140 POLY A POLYMERASE CID PAP -RELATED POLY(A) RNA POLYMERASE GLD2 transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;nucleotidyltransferase activity#GO:0016779;transferase activity, transferring phosphorus-containing groups#GO:0016772;adenylyltransferase activity#GO:0070566;catalytic activity, acting on RNA#GO:0140098 regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;positive regulation of catabolic process#GO:0009896;regulation of biosynthetic process#GO:0009889;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;biosynthetic process#GO:0009058;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;nucleic acid catabolic process#GO:0141188;macromolecule biosynthetic process#GO:0009059;regulation of primary metabolic process#GO:0080090;nucleobase-containing compound catabolic process#GO:0034655;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA metabolic process#GO:0051252;regulation of RNA stability#GO:0043487;RNA biosynthetic process#GO:0032774;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;positive regulation of mRNA catabolic process#GO:0061014;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA 3'-end processing#GO:0031123;regulation of mRNA metabolic process#GO:1903311;mRNA 3'-end processing#GO:0031124;metabolic process#GO:0008152;positive regulation of mRNA metabolic process#GO:1903313;macromolecule catabolic process#GO:0009057;nucleobase-containing compound biosynthetic process#GO:0034654;mRNA destabilization#GO:0061157;RNA processing#GO:0006396;positive regulation of macromolecule metabolic process#GO:0010604;gene expression#GO:0010467;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;mRNA processing#GO:0006397;RNA destabilization#GO:0050779;regulation of biological quality#GO:0065008;positive regulation of metabolic process#GO:0009893;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA catabolic process#GO:0006401;modification-dependent macromolecule catabolic process#GO:0043632;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;regulation of mRNA stability#GO:0043488;regulation of biological process#GO:0050789;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629 nucleotidyltransferase#PC00174 HUMAN|HGNC=6441|UniProtKB=P19013 P19013 KRT4 PTHR45616:SF3 GATA-TYPE DOMAIN-CONTAINING PROTEIN KERATIN, TYPE II CYTOSKELETAL 4 structural molecule activity#GO:0005198 anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;keratinocyte differentiation#GO:0030216;animal gross anatomical part developmental process#GO:0160108;intermediate filament-based process#GO:0045103;intermediate filament organization#GO:0045109;cell differentiation#GO:0030154;intermediate filament cytoskeleton organization#GO:0045104;cellular component organization#GO:0016043;animal organ development#GO:0048513;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;epidermis development#GO:0008544;developmental process#GO:0032502;multicellular organismal process#GO:0032501;epithelial cell differentiation#GO:0030855;tissue development#GO:0009888;epidermal cell differentiation#GO:0009913;epithelium development#GO:0060429;skin development#GO:0043588;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular process#GO:0009987 supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;organelle#GO:0043226;supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;intermediate filament#GO:0005882;supramolecular fiber#GO:0099512 HUMAN|HGNC=18888|UniProtKB=Q7RTR8 Q7RTR8 TAS2R42 PTHR11394:SF70 TASTE RECEPTOR TYPE 2 TASTE RECEPTOR TYPE 2 MEMBER 42 signaling receptor activity#GO:0038023;taste receptor activity#GO:0008527;bitter taste receptor activity#GO:0033038;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 response to chemical#GO:0042221;response to stimulus#GO:0050896;multicellular organismal process#GO:0032501;detection of chemical stimulus#GO:0009593;sensory perception of bitter taste#GO:0050913;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;system process#GO:0003008;detection of chemical stimulus involved in sensory perception of bitter taste#GO:0001580;sensory perception#GO:0007600;detection of chemical stimulus involved in sensory perception of taste#GO:0050912;nervous system process#GO:0050877;sensory perception of taste#GO:0050909;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907 cellular anatomical structure#GO:0110165;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=4089|UniProtKB=O00591 O00591 GABRP PTHR18945:SF33 NEUROTRANSMITTER GATED ION CHANNEL GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT PI transmembrane signaling receptor activity#GO:0004888;gated channel activity#GO:0022836;signaling receptor activity#GO:0038023;monoatomic ion transmembrane transporter activity#GO:0015075;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;monoatomic anion transmembrane transporter activity#GO:0008509;neurotransmitter receptor activity#GO:0030594;chloride channel activity#GO:0005254;channel activity#GO:0015267;monoatomic anion channel activity#GO:0005253;molecular transducer activity#GO:0060089;ligand-gated monoatomic ion channel activity#GO:0015276;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;chloride transmembrane transporter activity#GO:0015108 signaling#GO:0023052;anterograde trans-synaptic signaling#GO:0098916;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;monoatomic anion transport#GO:0006820;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698;transmembrane transport#GO:0055085;localization#GO:0051179;cell communication#GO:0007154;chloride transmembrane transport#GO:1902476;trans-synaptic signaling#GO:0099537;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;monoatomic anion transmembrane transport#GO:0098656;cellular process#GO:0009987;synaptic signaling#GO:0099536;establishment of localization#GO:0051234;transport#GO:0006810;chloride transport#GO:0006821 membrane#GO:0016020;cell periphery#GO:0071944;protein-containing complex#GO:0032991;synapse#GO:0045202;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;GABA-ergic synapse#GO:0098982;signaling receptor complex#GO:0043235;cell junction#GO:0030054 ligand-gated ion channel#PC00141 HUMAN|HGNC=6967|UniProtKB=Q99750 Q99750 MDFI PTHR15304:SF1 MYOD FAMILY INHIBITOR MYOD FAMILY INHIBITOR regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;regulation of signal transduction#GO:0009966;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of MAPK cascade#GO:0043408;regulation of biosynthetic process#GO:0009889;regulation of JNK cascade#GO:0046328;regulation of gene expression#GO:0010468;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111;negative regulation of metabolic process#GO:0009892;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=25628|UniProtKB=Q9NUU7 Q9NUU7 DDX19A PTHR47958:SF93 ATP-DEPENDENT RNA HELICASE DBP3 ATP-DEPENDENT RNA HELICASE DDX19A RNA binding#GO:0003723;ATP-dependent activity#GO:0140657;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;catalytic activity, acting on RNA#GO:0140098;isomerase activity#GO:0016853;helicase activity#GO:0004386;macromolecular conformation isomerase activity#GO:0120543;catalytic activity#GO:0003824;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;RNA helicase activity#GO:0003724 establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule localization#GO:0033036;nitrogen compound transport#GO:0071705;biosynthetic process#GO:0009058;gene expression#GO:0010467;transport#GO:0006810;metabolic process#GO:0008152;RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907;macromolecule metabolic process#GO:0043170;poly(A)+ mRNA export from nucleus#GO:0016973;establishment of localization#GO:0051234;mRNA transport#GO:0051028;establishment of RNA localization#GO:0051236;nucleobase-containing compound transport#GO:0015931;RNA transport#GO:0050658;RNA localization#GO:0006403;nucleocytoplasmic transport#GO:0006913;nuclear transport#GO:0051169;nuclear export#GO:0051168;localization#GO:0051179;nucleic acid transport#GO:0050657;cellular localization#GO:0051641;mRNA export from nucleus#GO:0006406 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytoplasmic stress granule#GO:0010494;membraneless organelle#GO:0043228;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;organelle#GO:0043226;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770 RNA helicase#PC00032 HUMAN|HGNC=129|UniProtKB=P68133 P68133 ACTA1 PTHR11937:SF193 ACTIN ACTIN, ALPHA SKELETAL MUSCLE structural molecule activity#GO:0005198;structural constituent of cytoskeleton#GO:0005200 organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;cellular anatomical entity morphogenesis#GO:0032989;developmental process#GO:0032502;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;actin filament organization#GO:0007015;striated muscle cell differentiation#GO:0051146;anatomical structure formation involved in morphogenesis#GO:0048646;muscle cell development#GO:0055001;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;myofibril assembly#GO:0030239;muscle cell differentiation#GO:0042692;cell differentiation#GO:0030154;muscle structure development#GO:0061061;actin cytoskeleton organization#GO:0030036;actomyosin structure organization#GO:0031032;cell development#GO:0048468;organelle assembly#GO:0070925;animal gross anatomical part developmental process#GO:0160108;cellular component assembly involved in morphogenesis#GO:0010927;actin filament-based process#GO:0030029;striated muscle cell development#GO:0055002;anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435 sarcomere#GO:0030017;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;actin filament#GO:0005884;stress fiber#GO:0001725;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;contractile muscle fiber#GO:0043292;actomyosin#GO:0042641;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;myofibril#GO:0030016;actin filament bundle#GO:0032432;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;actin cytoskeleton#GO:0015629 actin and actin related protein#PC00039 Wnt signaling pathway#P00057>NFAT Target Genes#G01559;Cadherin signaling pathway#P00012>F-actin#P00470;Cytoskeletal regulation by Rho GTPase#P00016>Actin#P00512;Alzheimer disease-presenilin pathway#P00004>actin#P00114;Huntington disease#P00029>Actin#P00807;Integrin signalling pathway#P00034>Actin#P00944;Nicotinic acetylcholine receptor signaling pathway#P00044>Actin#P01090;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>F-actin#P00858 HUMAN|HGNC=244|UniProtKB=P35612 P35612 ADD2 PTHR10672:SF6 ADDUCIN BETA-ADDUCIN binding#GO:0005488;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;actin filament binding#GO:0051015;protein binding#GO:0005515;protein-containing complex binding#GO:0044877 regulation of actin filament polymerization#GO:0030833;regulation of actin polymerization or depolymerization#GO:0008064;biological regulation#GO:0065007;negative regulation of protein depolymerization#GO:1901880;regulation of actin filament organization#GO:0110053;regulation of protein depolymerization#GO:1901879;regulation of actin filament-based process#GO:0032970;negative regulation of cellular process#GO:0048523;regulation of cytoskeleton organization#GO:0051493;negative regulation of supramolecular fiber organization#GO:1902904;regulation of protein polymerization#GO:0032271;regulation of cellular process#GO:0050794;regulation of actin filament depolymerization#GO:0030834;negative regulation of cellular component organization#GO:0051129;negative regulation of organelle organization#GO:0010639;regulation of supramolecular fiber organization#GO:1902903;negative regulation of cytoskeleton organization#GO:0051494;negative regulation of protein-containing complex disassembly#GO:0043242;negative regulation of protein-containing complex assembly#GO:0031333;actin filament capping#GO:0051693;negative regulation of protein polymerization#GO:0032272;regulation of actin cytoskeleton organization#GO:0032956;regulation of protein-containing complex disassembly#GO:0043244;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;regulation of anatomical structure size#GO:0090066;regulation of cellular component organization#GO:0051128;negative regulation of actin filament polymerization#GO:0030837;regulation of cellular component biogenesis#GO:0044087;negative regulation of biological process#GO:0048519;regulation of protein-containing complex assembly#GO:0043254;cellular component organization#GO:0016043;regulation of cellular component size#GO:0032535;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;regulation of biological quality#GO:0065008;negative regulation of actin filament depolymerization#GO:0030835;regulation of actin filament length#GO:0030832 intracellular anatomical structure#GO:0005622;postsynaptic density#GO:0014069;intracellular organelle#GO:0043229;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;asymmetric synapse#GO:0032279;postsynapse#GO:0098794;membraneless organelle#GO:0043228;cell junction#GO:0030054;cytoskeleton#GO:0005856;neuron to neuron synapse#GO:0098984;postsynaptic specialization#GO:0099572;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;membrane#GO:0016020;cell periphery#GO:0071944 non-motor actin binding protein#PC00165 HUMAN|HGNC=29970|UniProtKB=Q7RTZ1 Q7RTZ1 OVCH2 PTHR24251:SF16 OVOCHYMASE-RELATED OVOCHYMASE-2 serine-type peptidase activity#GO:0008236;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252 protease#PC00190;serine protease#PC00203 HUMAN|HGNC=9275|UniProtKB=P35813 P35813 PPM1A PTHR47992:SF121 PROTEIN PHOSPHATASE PROTEIN PHOSPHATASE 1A catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721;protein serine/threonine phosphatase activity#GO:0004722 positive regulation of canonical Wnt signaling pathway#GO:0090263;regulation of response to stimulus#GO:0048583;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;positive regulation of Wnt signaling pathway#GO:0030177;regulation of canonical NF-kappaB signal transduction#GO:0043122;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of canonical Wnt signaling pathway#GO:0060828;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;regulation of Wnt signaling pathway#GO:0030111;regulation of cell communication#GO:0010646;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;protein phosphatase#PC00195 HUMAN|HGNC=15959|UniProtKB=Q9H112 Q9H112 CST11 PTHR47886:SF1 CYSTATIN-11 CYSTATIN-11 response to bacterium#GO:0009617;defense response to bacterium#GO:0042742;response to external stimulus#GO:0009605;defense response#GO:0006952;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;response to stimulus#GO:0050896;defense response to Gram-negative bacterium#GO:0050829;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to other organism#GO:0051707 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;9+2 motile cilium#GO:0097729;cilium#GO:0005929;cell projection#GO:0042995;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;motile cilium#GO:0031514;organelle#GO:0043226;cellular anatomical structure#GO:0110165;sperm flagellum#GO:0036126;nucleus#GO:0005634 HUMAN|HGNC=25815|UniProtKB=Q96MT8 Q96MT8 CEP63 PTHR18875:SF7 SARCOMA ANTIGEN NY-SAR-24/CYTOSKELETAL PROTEIN SOJO CENTROSOMAL PROTEIN OF 63 KDA animal gross anatomical part developmental process#GO:0160108;organelle assembly#GO:0070925;centriole replication#GO:0007099;microtubule cytoskeleton organization#GO:0000226;anatomical structure development#GO:0048856;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;cell cycle#GO:0007049;cell cycle process#GO:0022402;centrosome cycle#GO:0007098;cell differentiation#GO:0030154;chromosome segregation#GO:0007059;developmental process#GO:0032502;cellular developmental process#GO:0048869;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;centrosome duplication#GO:0051298;microtubule-based process#GO:0007017;microtubule organizing center organization#GO:0031023;spindle assembly#GO:0051225;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;tissue development#GO:0009888;epithelial cell differentiation#GO:0030855;cellular component assembly#GO:0022607;epithelium development#GO:0060429;cytoskeleton organization#GO:0007010 microtubule cytoskeleton#GO:0015630;centriole#GO:0005814;intracellular membraneless organelle#GO:0043232;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;centrosome#GO:0005813;spindle#GO:0005819;membraneless organelle#GO:0043228;spindle pole#GO:0000922;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;intracellular organelle#GO:0043229;cilium#GO:0005929;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 cytoskeletal protein#PC00085 HUMAN|HGNC=15220|UniProtKB=Q8NGK6 Q8NGK6 OR52I1 PTHR26450:SF177 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 52I1-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=2335|UniProtKB=Q2VPA4 Q2VPA4 CR1L PTHR19325:SF534 COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING COMPLEMENT COMPONENT RECEPTOR 1-LIKE PROTEIN regulation of response to stimulus#GO:0048583;immune effector process#GO:0002252;immune response#GO:0006955;negative regulation of response to stimulus#GO:0048585;negative regulation of immune system process#GO:0002683;biological regulation#GO:0065007;adaptive immune response#GO:0002250;immune system process#GO:0002376;regulation of lymphocyte mediated immunity#GO:0002706;regulation of immune response#GO:0050776;T cell mediated immunity#GO:0002456;negative regulation of immune response#GO:0050777;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;regulation of immune effector process#GO:0002697;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of leukocyte mediated immunity#GO:0002703;response to stimulus#GO:0050896;regulation of immune system process#GO:0002682 cell periphery#GO:0071944;extracellular region#GO:0005576;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 complement component#PC00078;defense/immunity protein#PC00090 HUMAN|HGNC=27733|UniProtKB=Q6ZVF9 Q6ZVF9 GPRIN3 PTHR15718:SF6 G PROTEIN-REGULATED INDUCER OF NEURITE OUTGROWTH C-TERMINAL DOMAIN-CONTAINING PROTEIN G PROTEIN-REGULATED INDUCER OF NEURITE OUTGROWTH 3 cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell development#GO:0048468;cellular component organization#GO:0016043;anatomical structure development#GO:0048856;neuron development#GO:0048666;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;neuron projection development#GO:0031175;cellular process#GO:0009987;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;neurogenesis#GO:0022008;neuron differentiation#GO:0030182;developmental process#GO:0032502 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 HUMAN|HGNC=14742|UniProtKB=Q8NGD1 Q8NGD1 OR4N2 PTHR48002:SF120 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 4N2 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=10682|UniProtKB=Q99643 Q99643 SDHC PTHR10978:SF20 SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL electron transport chain#GO:0022900;mitochondrial ATP synthesis coupled electron transport#GO:0042775;cellular process#GO:0009987;respiratory electron transport chain#GO:0022904;metabolic process#GO:0008152;aerobic electron transport chain#GO:0019646;generation of precursor metabolites and energy#GO:0006091;mitochondrial electron transport, succinate to ubiquinone#GO:0006121;ATP synthesis coupled electron transport#GO:0042773;oxidative phosphorylation#GO:0006119;cellular respiration#GO:0045333;energy derivation by oxidation of organic compounds#GO:0015980;aerobic respiration#GO:0009060 respiratory chain complex#GO:0098803;membrane#GO:0016020;oxidoreductase complex#GO:1990204;membrane protein complex#GO:0098796;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494;respiratory chain complex II (succinate dehydrogenase)#GO:0045273 dehydrogenase#PC00092 TCA cycle#P00051>Succinate Dehydrogenase#P01273 HUMAN|HGNC=4285|UniProtKB=O75712 O75712 GJB3 PTHR11984:SF65 CONNEXIN GAP JUNCTION BETA-3 PROTEIN transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;channel activity#GO:0015267;wide pore channel activity#GO:0022829 regulation of biological process#GO:0050789;cellular process#GO:0009987;cell communication#GO:0007154;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;signaling#GO:0023052 cell junction#GO:0030054;anchoring junction#GO:0070161;membrane#GO:0016020;cell-cell junction#GO:0005911;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886 cell junction protein#PC00070;gap junction#PC00105 HUMAN|HGNC=701|UniProtKB=O00327 O00327 BMAL1 PTHR23042:SF52 CIRCADIAN PROTEIN CLOCK/ARNT/BMAL/PAS BASIC HELIX-LOOP-HELIX ARNT-LIKE PROTEIN 1 cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;circadian rhythm#GO:0007623;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;rhythmic process#GO:0048511;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;signaling receptor complex#GO:0043235;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;basic helix-loop-helix transcription factor#PC00055 Circadian clock system#P00015>bmal1#G01504;Hypoxia response via HIF activation#P00030>HIF-1beta#P00820;Circadian clock system#P00015>BMAL1#P00506;Circadian clock system#P00015>bmal1#G01500 HUMAN|HGNC=55079|UniProtKB=A6NIZ1 A6NIZ1 RAP1BL PTHR24070:SF393 RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY RAS-RELATED PROTEIN RAP-1B-RELATED ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818 response to oxygen-containing compound#GO:1901700;regulation of signaling#GO:0023051;cellular response to chemical stimulus#GO:0070887;regulation of neurotransmitter transport#GO:0051588;regulation of secretion by cell#GO:1903530;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;signaling#GO:0023052;regulation of synaptic vesicle exocytosis#GO:2000300;response to stimulus#GO:0050896;regulation of neurotransmitter secretion#GO:0046928;regulation of localization#GO:0032879;regulation of transport#GO:0051049;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987;intracellular signaling cassette#GO:0141124;response to chemical#GO:0042221;regulation of trans-synaptic signaling#GO:0099177;response to nitrogen compound#GO:1901698;intracellular signal transduction#GO:0035556;regulation of exocytosis#GO:0017157;regulation of secretion#GO:0051046;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;negative regulation of transport#GO:0051051;regulation of cellular process#GO:0050794;negative regulation of cellular process#GO:0048523;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;cellular response to nitrogen compound#GO:1901699 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 small GTPase#PC00208 Gonadotropin-releasing hormone receptor pathway#P06664>Rap1b#G06881;Gonadotropin-releasing hormone receptor pathway#P06664>Rap1b#P06803;Gonadotropin-releasing hormone receptor pathway#P06664>Rap1b#G06668;Integrin signalling pathway#P00034>Rap1#P00906;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Rap1#P00703;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Rap1#P00734 HUMAN|HGNC=34531|UniProtKB=A6NFE3 A6NFE3 EFCAB10 PTHR21847:SF1 EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 10 EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 10 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 cilium movement#GO:0003341;cellular process#GO:0009987;microtubule-based movement#GO:0007018;microtubule-based process#GO:0007017 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;axoneme#GO:0005930;cilium#GO:0005929;intracellular organelle#GO:0043229;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membraneless organelle#GO:0043228;radial spoke#GO:0001534;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;ciliary plasm#GO:0097014 calmodulin-related#PC00061 HUMAN|HGNC=2593|UniProtKB=P05093 P05093 CYP17A1 PTHR24289:SF13 STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE STEROID 17-ALPHA-HYDROXYLASE_17,20 LYASE steroid hydroxylase activity#GO:0008395;catalytic activity#GO:0003824;monooxygenase activity#GO:0004497;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen#GO:0016712 metabolic process#GO:0008152;olefinic compound metabolic process#GO:0120254;lipid metabolic process#GO:0006629;regulation of biological quality#GO:0065008;ketone metabolic process#GO:0042180;primary metabolic process#GO:0044238;regulation of hormone levels#GO:0010817;cellular process#GO:0009987;hormone metabolic process#GO:0042445;steroid metabolic process#GO:0008202;biosynthetic process#GO:0009058;hormone biosynthetic process#GO:0042446;biological regulation#GO:0065007 HUMAN|HGNC=7193|UniProtKB=O96007 O96007 MOCS2 PTHR23404:SF2 MOLYBDOPTERIN SYNTHASE RELATED MOLYBDOPTERIN SYNTHASE CATALYTIC SUBUNIT cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=30464|UniProtKB=Q96CN4 Q96CN4 EVI5L PTHR22957:SF254 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN EVI5-LIKE PROTEIN molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme activator activity#GO:0008047 protein-binding activity modulator#PC00095;G-protein modulator#PC00022;GTPase-activating protein#PC00257 HUMAN|HGNC=25107|UniProtKB=Q6IPT2 Q6IPT2 GARIN5A PTHR22574:SF5 FAMILY NOT NAMED GOLGI-ASSOCIATED RAB2 INTERACTOR PROTEIN 5A HUMAN|HGNC=3320|UniProtKB=Q9UKW6 Q9UKW6 ELF5 PTHR11849:SF15 ETS ETS-RELATED TRANSCRIPTION FACTOR ELF-5 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110 regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 winged helix/forkhead transcription factor#PC00246;DNA-binding transcription factor#PC00218 PDGF signaling pathway#P00047>Ets#P01167 HUMAN|HGNC=15751|UniProtKB=Q9H115 Q9H115 NAPB PTHR13768:SF12 SOLUBLE NSF ATTACHMENT PROTEIN SNAP BETA-SOLUBLE NSF ATTACHMENT PROTEIN protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;transport#GO:0006810;intracellular transport#GO:0046907;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;macromolecule localization#GO:0033036;cell communication#GO:0007154;localization#GO:0051179;trans-synaptic signaling#GO:0099537;protein-containing complex disassembly#GO:0032984;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;chemical synaptic transmission#GO:0007268;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;intracellular protein transport#GO:0006886;synaptic transmission, glutamatergic#GO:0035249;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;synaptic signaling#GO:0099536;protein transport#GO:0015031;cellular component disassembly#GO:0022411;cellular localization#GO:0051641;regulation of cellular component biogenesis#GO:0044087;signaling#GO:0023052;regulation of cellular component organization#GO:0051128;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;regulation of protein-containing complex assembly#GO:0043254 membrane#GO:0016020;neuron projection#GO:0043005;presynapse#GO:0098793;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;cell junction#GO:0030054;axon terminus#GO:0043679;membrane protein complex#GO:0098796;cellular anatomical structure#GO:0110165;SNARE complex#GO:0031201;synapse#GO:0045202;plasma membrane bounded cell projection#GO:0120025;terminal bouton#GO:0043195;distal axon#GO:0150034;cell projection#GO:0042995;neuron projection terminus#GO:0044306;axon#GO:0030424;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HUMAN|HGNC=31422|UniProtKB=Q5VTT2 Q5VTT2 CFAP95 PTHR35069:SF1 PROTEIN C9ORF135 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 95 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=10910|UniProtKB=Q13621 Q13621 SLC12A1 PTHR11827:SF93 SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS SOLUTE CARRIER FAMILY 12 MEMBER 1 sodium ion transmembrane transporter activity#GO:0015081;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;monoatomic anion transmembrane transporter activity#GO:0008509;chloride transmembrane transporter activity#GO:0015108;monoatomic cation transmembrane transporter activity#GO:0008324;potassium ion transmembrane transporter activity#GO:0015079;solute:sodium symporter activity#GO:0015370;symporter activity#GO:0015293 metal ion transport#GO:0030001;sodium ion transport#GO:0006814;monoatomic anion transport#GO:0006820;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transmembrane transport#GO:0034220;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;establishment of localization#GO:0051234;transport#GO:0006810;chloride transport#GO:0006821 cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;plasma membrane#GO:0005886;membrane#GO:0016020;apical plasma membrane#GO:0016324;cell periphery#GO:0071944;apical part of cell#GO:0045177 secondary carrier transporter#PC00258 HUMAN|HGNC=11871|UniProtKB=P28289 P28289 TMOD1 PTHR10901:SF8 TROPOMODULIN TROPOMODULIN-1 protein binding#GO:0005515;binding#GO:0005488;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092 cellular developmental process#GO:0048869;system process#GO:0003008;actin filament organization#GO:0007015;muscle contraction#GO:0006936;developmental process#GO:0032502;multicellular organismal process#GO:0032501;anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;organelle assembly#GO:0070925;cellular component assembly involved in morphogenesis#GO:0010927;actin filament-based process#GO:0030029;actin cytoskeleton organization#GO:0030036;muscle structure development#GO:0061061;muscle cell development#GO:0055001;myofibril assembly#GO:0030239;muscle cell differentiation#GO:0042692;cellular component organization or biogenesis#GO:0071840;striated muscle cell differentiation#GO:0051146;anatomical structure formation involved in morphogenesis#GO:0048646;cellular anatomical entity morphogenesis#GO:0032989;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;striated muscle cell development#GO:0055002;animal gross anatomical part developmental process#GO:0160108;cell differentiation#GO:0030154;actomyosin structure organization#GO:0031032;cell development#GO:0048468;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;anatomical structure morphogenesis#GO:0009653;muscle system process#GO:0003012 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;myofibril#GO:0030016;membraneless organelle#GO:0043228;sarcomere#GO:0030017;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;actin cytoskeleton#GO:0015629;contractile muscle fiber#GO:0043292;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;organelle#GO:0043226;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=23641|UniProtKB=Q9BS92 Q9BS92 NIPSNAP3B PTHR21017:SF18 NIPSNAP-RELATED PROTEIN NIPSNAP HOMOLOG 3B molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 mitophagy#GO:0000423;process utilizing autophagic mechanism#GO:0061919;autophagy of mitochondrion#GO:0000422;metabolic process#GO:0008152;catabolic process#GO:0009056;macroautophagy#GO:0016236;cellular process#GO:0009987;autophagy#GO:0006914 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=30209|UniProtKB=Q8IVA1 Q8IVA1 PCP2 PTHR47503:SF1 PURKINJE CELL PROTEIN 2 PURKINJE CELL PROTEIN 2 HOMOLOG molecular function regulator activity#GO:0098772;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;guanyl-nucleotide exchange factor activity#GO:0005085 HUMAN|HGNC=6636|UniProtKB=P02545 P02545 LMNA PTHR45721:SF5 LAMIN DM0-RELATED PRELAMIN-A_C structural constituent of cytoskeleton#GO:0005200;structural molecule activity#GO:0005198 cellular component organization or biogenesis#GO:0071840;negative regulation of gene expression, epigenetic#GO:0045814;endomembrane system organization#GO:0010256;heterochromatin organization#GO:0070828;cellular component assembly#GO:0022607;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular localization#GO:0051641;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;establishment of organelle localization#GO:0051656;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;intracellular protein localization#GO:0008104;regulation of gene expression#GO:0010468;nuclear envelope organization#GO:0006998;regulation of biosynthetic process#GO:0009889;nucleus organization#GO:0006997;establishment of localization#GO:0051234;transport#GO:0006810;negative regulation of cellular process#GO:0048523;intracellular transport#GO:0046907;chromatin organization#GO:0006325;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;membrane organization#GO:0061024;negative regulation of macromolecule metabolic process#GO:0010605;macromolecule localization#GO:0033036;epigenetic regulation of gene expression#GO:0040029;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;protein localization to nucleus#GO:0034504;localization#GO:0051179;localization within membrane#GO:0051668;organelle localization#GO:0051640;regulation of macromolecule metabolic process#GO:0060255;protein localization to organelle#GO:0033365;regulation of cellular process#GO:0050794;heterochromatin formation#GO:0031507;nuclear migration#GO:0007097 organelle envelope#GO:0031967;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;organelle#GO:0043226;nuclear lumen#GO:0031981;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;nuclear periphery#GO:0034399;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 FAS signaling pathway#P00020>Nuclear Lamin#P00616 HUMAN|HGNC=12828|UniProtKB=P18887 P18887 XRCC1 PTHR11370:SF6 DNA-REPAIR PROTEIN XRCC1 DNA REPAIR PROTEIN XRCC1 DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;response to stress#GO:0006950;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;base-excision repair#GO:0006284;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 DNA metabolism protein#PC00009 HUMAN|HGNC=28535|UniProtKB=Q8IWF9 Q8IWF9 CCDC83 PTHR21468:SF1 HSD9 COILED-COIL DOMAIN-CONTAINING PROTEIN 83 HUMAN|HGNC=14638|UniProtKB=Q86UQ4 Q86UQ4 ABCA13 PTHR19229:SF113 ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 13 active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626;molecular carrier activity#GO:0140104;lipid carrier activity#GO:0005319 macromolecule localization#GO:0033036;lipid localization#GO:0010876;transport#GO:0006810;lipid transport#GO:0006869;localization#GO:0051179;establishment of localization#GO:0051234 intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 ATP-binding cassette (ABC) transporter#PC00003 HUMAN|HGNC=24759|UniProtKB=Q6ZUI0 Q6ZUI0 TPRG1 PTHR31108:SF6 TUMOR PROTEIN P63-REGULATED GENE 1-LIKE PROTEIN TUMOR PROTEIN P63-REGULATED GENE 1 PROTEIN intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=5418|UniProtKB=P01566 P01566 IFNA10 PTHR11691:SF66 TYPE I INTERFERON INTERFERON ALPHA-10-RELATED molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;protein-containing complex binding#GO:0044877;molecular function activator activity#GO:0140677;protein binding#GO:0005515;cytokine receptor binding#GO:0005126;signaling receptor binding#GO:0005102;binding#GO:0005488;cytokine activity#GO:0005125 cellular process#GO:0009987;signal transduction#GO:0007165;defense response to symbiont#GO:0140546;lymphocyte activation involved in immune response#GO:0002285;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;T cell activation involved in immune response#GO:0002286;defense response to other organism#GO:0098542;lymphocyte activation#GO:0046649;response to cytokine#GO:0034097;response to chemical#GO:0042221;leukocyte activation involved in immune response#GO:0002366;natural killer cell activation#GO:0030101;immune effector process#GO:0002252;cell surface receptor signaling pathway#GO:0007166;humoral immune response#GO:0006959;B cell activation#GO:0042113;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;T cell activation#GO:0042110;biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052;response to stimulus#GO:0050896;B cell activation involved in immune response#GO:0002312;type I interferon-mediated signaling pathway#GO:0060337;immune system process#GO:0002376;cell activation involved in immune response#GO:0002263;response to peptide#GO:1901652;immune response#GO:0006955;adaptive immune response#GO:0002250;response to other organism#GO:0051707;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;defense response#GO:0006952;response to external stimulus#GO:0009605;innate immune response#GO:0045087;cellular response to stimulus#GO:0051716;leukocyte activation#GO:0045321;response to external biotic stimulus#GO:0043207;regulation of cellular process#GO:0050794;cell activation#GO:0001775;cytokine-mediated signaling pathway#GO:0019221;response to nitrogen compound#GO:1901698;cell communication#GO:0007154 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 interferon superfamily#PC00127;cytokine#PC00083 HUMAN|HGNC=9642|UniProtKB=P18031 P18031 PTPN1 PTHR46047:SF2 TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 61F TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1 catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;phosphoprotein phosphatase activity#GO:0004721;protein tyrosine phosphatase activity#GO:0004725;hydrolase activity#GO:0016787;protein binding#GO:0005515;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;kinase binding#GO:0019900;binding#GO:0005488 regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;negative regulation of ERK1 and ERK2 cascade#GO:0070373;regulation of ERK1 and ERK2 cascade#GO:0070372;negative regulation of response to stimulus#GO:0048585;regulation of MAPK cascade#GO:0043408;regulation of receptor signaling pathway via JAK-STAT#GO:0046425;regulation of response to stimulus#GO:0048583;regulation of response to stress#GO:0080134;negative regulation of cellular process#GO:0048523;regulation of receptor signaling pathway via STAT#GO:1904892;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of response to endoplasmic reticulum stress#GO:1905897;negative regulation of MAPK cascade#GO:0043409;negative regulation of biological process#GO:0048519;regulation of cellular response to stress#GO:0080135;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531 intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular vesicle#GO:0097708;nucleus#GO:0005634;vesicle#GO:0031982 protein phosphatase#PC00195;protein modifying enzyme#PC00260 Cadherin signaling pathway#P00012>Tyrosine phosphatases#P00472 HUMAN|HGNC=32930|UniProtKB=Q6UXB1 Q6UXB1 IGFL3 PTHR34827:SF5 INSULIN GROWTH FACTOR-LIKE FAMILY MEMBER 3-RELATED INSULIN GROWTH FACTOR-LIKE FAMILY MEMBER 3 protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 growth factor#PC00112;intercellular signal molecule#PC00207 HUMAN|HGNC=26279|UniProtKB=Q8TAW3 Q8TAW3 ZNF671 PTHR24390:SF44 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 671 DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218 HUMAN|HGNC=32043|UniProtKB=Q6UWJ8 Q6UWJ8 CD164L2 PTHR11337:SF11 MUCIN/PORIMIN CD164 SIALOMUCIN-LIKE 2 PROTEIN organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229 HUMAN|HGNC=16502|UniProtKB=P58872 P58872 RHBDL3 PTHR45840:SF5 RHOMBOID-RELATED PROTEIN RHOMBOID-RELATED PROTEIN 3 catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;serine-type peptidase activity#GO:0008236 HUMAN|HGNC=8874|UniProtKB=Q16875 Q16875 PFKFB3 PTHR10606:SF41 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE 6-PHOSPHOFRUCTO-2-KINASE_FRUCTOSE-2,6-BISPHOSPHATASE 3 phosphoric ester hydrolase activity#GO:0042578;transferase activity#GO:0016740;catalytic activity#GO:0003824;carbohydrate kinase activity#GO:0019200;hydrolase activity, acting on ester bonds#GO:0016788;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphatase activity#GO:0016791;phosphotransferase activity, alcohol group as acceptor#GO:0016773;hydrolase activity#GO:0016787;sugar-phosphatase activity#GO:0050308 carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;metabolic process#GO:0008152;phosphorus metabolic process#GO:0006793 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 hydrolase#PC00121;carbohydrate phosphatase#PC00066;phosphatase#PC00181 HUMAN|HGNC=11422|UniProtKB=A8MT69 A8MT69 CENPX PTHR28680:SF2 CENTROMERE PROTEIN X CENTROMERE PROTEIN X nucleobase-containing compound metabolic process#GO:0006139;replication fork processing#GO:0031297;organelle organization#GO:0006996;resolution of meiotic recombination intermediates#GO:0000712;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;meiotic nuclear division#GO:0140013;meiotic cell cycle#GO:0051321;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;DNA recombination#GO:0006310;reproductive process#GO:0022414;homologous recombination#GO:0035825;cell cycle#GO:0007049;meiotic cell cycle process#GO:1903046;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;meiosis I#GO:0007127;reciprocal homologous recombination#GO:0140527;cell cycle process#GO:0022402;DNA replication#GO:0006260;DNA-templated DNA replication#GO:0006261;organelle fission#GO:0048285;meiosis I cell cycle process#GO:0061982;nuclear division#GO:0000280;sexual reproduction#GO:0019953;reciprocal meiotic recombination#GO:0007131 organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Fanconi anaemia nuclear complex#GO:0043240;intracellular organelle#GO:0043229 HUMAN|HGNC=24733|UniProtKB=A2VDF0 A2VDF0 FUOM PTHR31690:SF4 FUCOSE MUTAROTASE FUCOSE MUTAROTASE carbohydrate binding#GO:0030246;monosaccharide binding#GO:0048029;isomerase activity#GO:0016853;catalytic activity#GO:0003824;racemase and epimerase activity#GO:0016854;racemase and epimerase activity, acting on carbohydrates and derivatives#GO:0016857;small molecule binding#GO:0036094;binding#GO:0005488 metabolic process#GO:0008152;primary metabolic process#GO:0044238;monosaccharide metabolic process#GO:0005996;hexose metabolic process#GO:0019318;cellular process#GO:0009987;small molecule metabolic process#GO:0044281;carbohydrate metabolic process#GO:0005975 HUMAN|HGNC=18324|UniProtKB=Q9H2F3 Q9H2F3 HSD3B7 PTHR10366:SF847 NAD DEPENDENT EPIMERASE/DEHYDRATASE 3 BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 7 oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 metabolite interconversion enzyme#PC00262;dehydratase#PC00091;lyase#PC00144 Androgen/estrogene/progesterone biosynthesis#P02727>3beta-hydroxy-Delta5-steroid dehydrogenase#P02837 HUMAN|HGNC=31675|UniProtKB=Q9Y5A9 Q9Y5A9 YTHDF2 PTHR12357:SF8 YTH YT521-B HOMOLOGY DOMAIN-CONTAINING YTH DOMAIN-CONTAINING FAMILY PROTEIN 2 binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;protein-RNA adaptor activity#GO:0140517;RNA binding#GO:0003723 negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;positive regulation of catabolic process#GO:0009896;regulation of biosynthetic process#GO:0009889;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA stability#GO:0043487;regulation of RNA metabolic process#GO:0051252;positive regulation of mRNA catabolic process#GO:0061014;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;mRNA destabilization#GO:0061157;positive regulation of mRNA metabolic process#GO:1903313;regulation of mRNA metabolic process#GO:1903311;negative regulation of macromolecule biosynthetic process#GO:0010558;RNA destabilization#GO:0050779;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of metabolic process#GO:0009893;regulation of biological quality#GO:0065008;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;negative regulation of metabolic process#GO:0009892;regulation of mRNA stability#GO:0043488 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HUMAN|HGNC=11453|UniProtKB=P50225 P50225 SULT1A1 PTHR11783:SF156 SULFOTRANSFERASE SULT SULFOTRANSFERASE 1A1 transferase activity, transferring sulphur-containing groups#GO:0016782;sulfotransferase activity#GO:0008146;catalytic activity#GO:0003824;transferase activity#GO:0016740 metabolic process#GO:0008152;sulfur compound metabolic process#GO:0006790;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;transferase#PC00220 HUMAN|HGNC=24269|UniProtKB=Q9Y315 Q9Y315 DERA PTHR10889:SF3 DEOXYRIBOSE-PHOSPHATE ALDOLASE DEOXYRIBOSE-PHOSPHATE ALDOLASE carbon-carbon lyase activity#GO:0016830;catalytic activity#GO:0003824;aldehyde-lyase activity#GO:0016832;lyase activity#GO:0016829 metabolic process#GO:0008152;nucleoside catabolic process#GO:0009164;nucleobase-containing small molecule metabolic process#GO:0055086;glycosyl compound catabolic process#GO:1901658;primary metabolic process#GO:0044238;nucleobase-containing small molecule catabolic process#GO:0034656;nucleobase-containing compound catabolic process#GO:0034655;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;nucleoside metabolic process#GO:0009116;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;carbohydrate derivative catabolic process#GO:1901136;small molecule catabolic process#GO:0044282;nucleobase-containing compound metabolic process#GO:0006139 aldolase#PC00044;lyase#PC00144 HUMAN|HGNC=18938|UniProtKB=Q7Z4W3 Q7Z4W3 KRTAP19-3 PTHR38140:SF9 KERATIN-ASSOCIATED PROTEIN 19-3-RELATED KERATIN-ASSOCIATED PROTEIN 19-3 structural protein#PC00211 HUMAN|HGNC=12142|UniProtKB=A0A0B4J266 A0A0B4J266 TRAV41 PTHR19339:SF0 T CELL RECEPTOR ALPHA VARIABLE 39 T CELL RECEPTOR ALPHA VARIABLE 41 HUMAN|HGNC=11073|UniProtKB=P48764 P48764 SLC9A3 PTHR10110:SF90 SODIUM/HYDROGEN EXCHANGER SODIUM_HYDROGEN EXCHANGER 3 monoatomic ion transmembrane transporter activity#GO:0015075;metal cation:proton antiporter activity#GO:0051139;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;active transmembrane transporter activity#GO:0022804;antiporter activity#GO:0015297;proton transmembrane transporter activity#GO:0015078;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324 import into cell#GO:0098657;establishment of localization#GO:0051234;inorganic cation import across plasma membrane#GO:0098659;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;transport#GO:0006810;intracellular monoatomic cation homeostasis#GO:0030003;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;potassium ion transmembrane transport#GO:0071805;biological regulation#GO:0065007;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;regulation of pH#GO:0006885;regulation of intracellular pH#GO:0051453;import across plasma membrane#GO:0098739;inorganic ion import across plasma membrane#GO:0099587;homeostatic process#GO:0042592;metal ion transport#GO:0030001;intracellular monoatomic ion homeostasis#GO:0006873;sodium ion transport#GO:0006814 apical part of cell#GO:0045177;cluster of actin-based cell projections#GO:0098862;cell projection membrane#GO:0031253;brush border#GO:0005903;cell periphery#GO:0071944;membrane#GO:0016020;apical plasma membrane#GO:0016324;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;plasma membrane#GO:0005886;brush border membrane#GO:0031526;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590 secondary carrier transporter#PC00258 HUMAN|HGNC=1323|UniProtKB=P0C0L4 P0C0L4 C4A PTHR11412:SF86 MACROGLOBULIN / COMPLEMENT COMPLEMENT C4-A-RELATED protein binding#GO:0005515;chemokine receptor binding#GO:0042379;molecular function activator activity#GO:0140677;cytokine activity#GO:0005125;binding#GO:0005488;signaling receptor binding#GO:0005102;cytokine receptor binding#GO:0005126;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;chemokine activity#GO:0008009;G protein-coupled receptor binding#GO:0001664 immune system process#GO:0002376;response to external stimulus#GO:0009605;defense response#GO:0006952;innate immune response#GO:0045087;immune response#GO:0006955;defense response to symbiont#GO:0140546;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to other organism#GO:0051707;response to stimulus#GO:0050896;defense response to other organism#GO:0098542 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494;extracellular protein-containing complex#GO:0140392;extracellular region#GO:0005576 protease inhibitor#PC00191 HUMAN|HGNC=51677|UniProtKB=H7BZ55 H7BZ55 CROCC2 PTHR23159:SF16 CENTROSOMAL PROTEIN 2 CILIARY ROOTLET COILED-COIL PROTEIN 2 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;centrosome#GO:0005813;intracellular membraneless organelle#GO:0043232;centriole#GO:0005814;cellular anatomical structure#GO:0110165;organelle#GO:0043226;microtubule cytoskeleton#GO:0015630 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=26616|UniProtKB=Q8NB37 Q8NB37 GATD1 PTHR48094:SF18 PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED GLUTAMINE AMIDOTRANSFERASE-LIKE CLASS 1 DOMAIN-CONTAINING PROTEIN 1 HUMAN|HGNC=30827|UniProtKB=O95990 O95990 FAM107A PTHR16768:SF3 DOWN REGULATED IN RENAL CARCINOMA 1/TU3A ACTIN-ASSOCIATED PROTEIN FAM107A cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;actin filament organization#GO:0007015;regulation of actin filament-based process#GO:0032970;cellular component assembly#GO:0022607;regulation of actin cytoskeleton organization#GO:0032956;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;actin polymerization or depolymerization#GO:0008154;cellular process#GO:0009987;supramolecular fiber organization#GO:0097435;actin filament-based process#GO:0030029;regulation of cellular process#GO:0050794;actin cytoskeleton organization#GO:0030036;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;actin filament polymerization#GO:0030041;cellular component organization#GO:0016043;regulation of organelle organization#GO:0033043;actin filament bundle organization#GO:0061572;actin filament bundle assembly#GO:0051017;protein-containing complex assembly#GO:0065003;protein polymerization#GO:0051258;regulation of biological process#GO:0050789 organelle#GO:0043226;cellular anatomical structure#GO:0110165;synapse#GO:0045202;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;actin cytoskeleton#GO:0015629;actin filament bundle#GO:0032432;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membraneless organelle#GO:0043232;neuron projection#GO:0043005;actomyosin#GO:0042641;cell junction#GO:0030054;membraneless organelle#GO:0043228;stress fiber#GO:0001725;cytoskeleton#GO:0005856 HUMAN|HGNC=19236|UniProtKB=Q96CS7 Q96CS7 PLEKHB2 PTHR14309:SF8 EXPRESSED PROTEIN PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY B MEMBER 2 membrane#GO:0016020;cellular anatomical structure#GO:0110165 HUMAN|HGNC=29943|UniProtKB=Q9NT68 Q9NT68 TENM2 PTHR11219:SF8 TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE TENEURIN-2 binding#GO:0005488;signaling receptor binding#GO:0005102;protein binding#GO:0005515 cell adhesion#GO:0007155;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;synaptic membrane adhesion#GO:0099560;axonogenesis#GO:0007409;neuron development#GO:0048666;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;cell development#GO:0048468;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell morphogenesis#GO:0000902;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell projection morphogenesis#GO:0048858;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;neuron projection development#GO:0031175;cell-cell adhesion#GO:0098609;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;synapse organization#GO:0050808;system development#GO:0048731;anatomical structure development#GO:0048856;cell junction organization#GO:0034330;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;axon development#GO:0061564;axon guidance#GO:0007411;plasma membrane bounded cell projection organization#GO:0120036;multicellular organismal process#GO:0032501 cell junction#GO:0030054;membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005;cellular anatomical structure#GO:0110165;synapse#GO:0045202;glutamatergic synapse#GO:0098978;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;cell projection#GO:0042995 HUMAN|HGNC=5999|UniProtKB=Q9HB29 Q9HB29 IL1RL2 PTHR11890:SF9 INTERLEUKIN-1 RECEPTOR FAMILY MEMBER INTERLEUKIN-1 RECEPTOR-LIKE 2 cell communication#GO:0007154;regulation of response to stress#GO:0080134;regulation of response to stimulus#GO:0048583;regulation of defense response#GO:0031347;regulation of inflammatory response#GO:0050727;cell surface receptor signaling pathway#GO:0007166;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of response to external stimulus#GO:0032101;biological regulation#GO:0065007;signaling#GO:0023052;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell surface#GO:0009986 transmembrane signal receptor#PC00197 HUMAN|HGNC=13495|UniProtKB=Q5VT40 Q5VT40 FAM78B PTHR31655:SF0 PROTEIN FAM78A PROTEIN FAM78B HUMAN|HGNC=10802|UniProtKB=P11686 P11686 SFTPC PTHR10800:SF7 PULMONARY SURFACTANT-ASSOCIATED PROTEIN C SURFACTANT PROTEIN C cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;vesicle#GO:0031982;secretory vesicle#GO:0099503;intracellular vesicle#GO:0097708;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;extracellular region#GO:0005576;intracellular organelle#GO:0043229 surfactant#PC00212;structural protein#PC00211 HUMAN|HGNC=28074|UniProtKB=Q49B96 Q49B96 COX19 PTHR21107:SF2 CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19 CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19 protein-containing complex organization#GO:0043933;respiratory chain complex IV assembly#GO:0008535;cellular component organization or biogenesis#GO:0071840;cytochrome complex assembly#GO:0017004;mitochondrial respiratory chain complex IV assembly#GO:0033617;mitochondrion organization#GO:0007005;mitochondrial respiratory chain complex assembly#GO:0033108;cellular component assembly#GO:0022607;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular component organization#GO:0016043 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;organelle envelope#GO:0031967;mitochondrial envelope#GO:0005740;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;mitochondrial intermembrane space#GO:0005758;intracellular organelle#GO:0043229 chaperone#PC00072 HUMAN|HGNC=3696|UniProtKB=Q14314 Q14314 FGL2 PTHR19143:SF189 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBROLEUKIN cellular anatomical structure#GO:0110165;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HUMAN|HGNC=7533|UniProtKB=P20592 P20592 MX2 PTHR11566:SF46 DYNAMIN INTERFERON-INDUCED GTP-BINDING PROTEIN MX2 protein binding#GO:0005515;hydrolase activity#GO:0016787;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924;microtubule binding#GO:0008017;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;tubulin binding#GO:0015631;hydrolase activity, acting on acid anhydrides#GO:0016817;cytoskeletal protein binding#GO:0008092 cellular component organization#GO:0016043;defense response to virus#GO:0051607;establishment of organelle localization#GO:0051656;endocytosis#GO:0006897;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;cellular localization#GO:0051641;synaptic vesicle transport#GO:0048489;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;synaptic vesicle localization#GO:0097479;establishment of vesicle localization#GO:0051650;vesicle-mediated transport in synapse#GO:0099003;import into cell#GO:0098657;cellular component organization or biogenesis#GO:0071840;vesicle organization#GO:0016050;synaptic vesicle endocytosis#GO:0048488;response to external biotic stimulus#GO:0043207;organelle localization#GO:0051640;response to virus#GO:0009615;localization#GO:0051179;vesicle localization#GO:0051648;synaptic vesicle recycling#GO:0036465;response to other organism#GO:0051707;membrane organization#GO:0061024;synaptic vesicle cycle#GO:0099504;transport#GO:0006810;establishment of localization#GO:0051234;defense response#GO:0006952;vesicle budding from membrane#GO:0006900;response to external stimulus#GO:0009605 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;synapse#GO:0045202;intracellular organelle#GO:0043229;supramolecular fiber#GO:0099512;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;nucleus#GO:0005634;microtubule cytoskeleton#GO:0015630;membrane#GO:0016020;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;cytoskeleton#GO:0005856;cell junction#GO:0030054;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228 membrane traffic protein#PC00150 HUMAN|HGNC=20367|UniProtKB=Q5TBA9 Q5TBA9 FRY PTHR12295:SF29 FURRY-RELATED PROTEIN FURRY HOMOLOG anatomical structure development#GO:0048856;system development#GO:0048731;neuron development#GO:0048666;establishment or maintenance of cell polarity#GO:0007163;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell morphogenesis#GO:0000902;cell development#GO:0048468;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;developmental process#GO:0032502;neuron differentiation#GO:0030182;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;nervous system development#GO:0007399;neuron projection development#GO:0031175;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cell division site#GO:0032153 scaffold/adaptor protein#PC00226 HUMAN|HGNC=29826|UniProtKB=Q32MK0 Q32MK0 MYLK3 PTHR24347:SF394 SERINE/THREONINE-PROTEIN KINASE MYOSIN LIGHT CHAIN KINASE 3 catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 cellular component assembly#GO:0022607;heart development#GO:0007507;cytoskeleton organization#GO:0007010;cardiac muscle cell differentiation#GO:0055007;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;signal transduction#GO:0007165;cellular process#GO:0009987;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;animal organ development#GO:0048513;anatomical structure formation involved in morphogenesis#GO:0048646;striated muscle cell differentiation#GO:0051146;cellular anatomical entity morphogenesis#GO:0032989;striated muscle tissue development#GO:0014706;response to stimulus#GO:0050896;circulatory system development#GO:0072359;cell differentiation#GO:0030154;signaling#GO:0023052;actomyosin structure organization#GO:0031032;cell development#GO:0048468;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;striated muscle cell development#GO:0055002;animal gross anatomical part developmental process#GO:0160108;multicellular organismal process#GO:0032501;tissue development#GO:0009888;biological regulation#GO:0065007;cellular developmental process#GO:0048869;cardiac muscle tissue development#GO:0048738;developmental process#GO:0032502;muscle structure development#GO:0061061;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;muscle cell development#GO:0055001;muscle cell differentiation#GO:0042692;myofibril assembly#GO:0030239;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;muscle tissue development#GO:0060537;system development#GO:0048731;organelle assembly#GO:0070925;cellular component assembly involved in morphogenesis#GO:0010927;actin filament-based process#GO:0030029;sarcomere organization#GO:0045214 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;actin cytoskeleton#GO:0015629;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226 non-receptor serine/threonine protein kinase#PC00167 Cytoskeletal regulation by Rho GTPase#P00016>MLCK#P00514;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>MLCK#P00877 HUMAN|HGNC=25418|UniProtKB=Q96C34 Q96C34 RUNDC1 PTHR47194:SF5 SORTING NEXIN-29-RELATED RUN DOMAIN-CONTAINING PROTEIN 1 scaffold/adaptor protein#PC00226 HUMAN|HGNC=29913|UniProtKB=Q86WB0 Q86WB0 ZC3HC1 PTHR15835:SF6 NUCLEAR-INTERACTING PARTNER OF ALK ZINC FINGER C3HC-TYPE PROTEIN 1 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=583|UniProtKB=P25054 P25054 APC PTHR12607:SF11 ADENOMATOUS POLYPOSIS COLI PROTEIN FAMILY ADENOMATOUS POLYPOSIS COLI PROTEIN protein binding#GO:0005515;beta-catenin binding#GO:0008013;microtubule binding#GO:0008017;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631 negative regulation of Wnt signaling pathway#GO:0030178;cell migration#GO:0016477;multicellular organismal process#GO:0032501;negative regulation of response to stimulus#GO:0048585;negative regulation of protein depolymerization#GO:1901880;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;developmental process#GO:0032502;cellular developmental process#GO:0048869;regulation of microtubule polymerization or depolymerization#GO:0031110;regulation of protein depolymerization#GO:1901879;negative regulation of cellular component organization#GO:0051129;negative regulation of organelle organization#GO:0010639;regulation of supramolecular fiber organization#GO:1902903;regulation of cellular process#GO:0050794;cell motility#GO:0048870;negative regulation of supramolecular fiber organization#GO:1902904;regulation of cytoskeleton organization#GO:0051493;regulation of cell communication#GO:0010646;regulation of microtubule-based process#GO:0032886;pattern specification process#GO:0007389;anatomical structure development#GO:0048856;negative regulation of protein-containing complex disassembly#GO:0043242;negative regulation of cytoskeleton organization#GO:0051494;system development#GO:0048731;regulation of canonical Wnt signaling pathway#GO:0060828;regulation of protein-containing complex disassembly#GO:0043244;cellular process#GO:0009987;nervous system development#GO:0007399;negative regulation of signal transduction#GO:0009968;regulation of microtubule cytoskeleton organization#GO:0070507;cell fate specification#GO:0001708;multicellular organism development#GO:0007275;negative regulation of biological process#GO:0048519;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;cell differentiation#GO:0030154;regulation of cellular component organization#GO:0051128;regulation of Wnt signaling pathway#GO:0030111;animal gross anatomical part developmental process#GO:0160108;negative regulation of canonical Wnt signaling pathway#GO:0090090;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;negative regulation of cell communication#GO:0010648;cell fate commitment#GO:0045165 intracellular protein-containing complex#GO:0140535;polymeric cytoskeletal fiber#GO:0099513;extrinsic component of plasma membrane#GO:0019897;membraneless organelle#GO:0043228;extrinsic component of membrane#GO:0019898;cytoskeleton#GO:0005856;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cell periphery#GO:0071944;membrane#GO:0016020;microtubule cytoskeleton#GO:0015630;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;microtubule#GO:0005874;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane protein complex#GO:0098797;cytoplasmic microtubule#GO:0005881;membrane protein complex#GO:0098796 Wnt signaling pathway#P00057>APC#P01468;Angiogenesis#P00005>APC#P00195 HUMAN|HGNC=3826|UniProtKB=P21462 P21462 FPR1 PTHR24225:SF15 CHEMOTACTIC RECEPTOR N-FORMYL PEPTIDE RECEPTOR 1 G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;immune receptor activity#GO:0140375;peptide receptor activity#GO:0001653 regulation of biological quality#GO:0065008;cell communication#GO:0007154;phospholipase C-activating G protein-coupled receptor signaling pathway#GO:0007200;regulation of immune response#GO:0050776;G protein-coupled receptor signaling pathway#GO:0007186;immune system process#GO:0002376;positive regulation of cytosolic calcium ion concentration#GO:0007204;immune response-activating cell surface receptor signaling pathway#GO:0002429;signaling#GO:0023052;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;immune response-regulating signaling pathway#GO:0002764;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;immune response-activating signaling pathway#GO:0002757;cell surface receptor signaling pathway#GO:0007166;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;activation of immune response#GO:0002253;positive regulation of immune system process#GO:0002684 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CHKR#P00854 HUMAN|HGNC=8688|UniProtKB=Q9Y5E6 Q9Y5E6 PCDHB3 PTHR24028:SF302 CADHERIN-87A PROTOCADHERIN BETA-3 cellular process#GO:0009987;cell adhesion#GO:0007155 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 cadherin#PC00057;cell adhesion molecule#PC00069 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HUMAN|HGNC=19119|UniProtKB=Q8N695 Q8N695 SLC5A8 PTHR42985:SF10 SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER 1 solute:sodium symporter activity#GO:0015370;monoatomic cation transmembrane transporter activity#GO:0008324;symporter activity#GO:0015293;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;secondary active transmembrane transporter activity#GO:0015291 monocarboxylic acid transport#GO:0015718;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;localization#GO:0051179;fatty acid transport#GO:0015908;monoatomic cation transport#GO:0006812;lipid localization#GO:0010876;carboxylic acid transmembrane transport#GO:1905039;metal ion transport#GO:0030001;sodium ion transport#GO:0006814;establishment of localization#GO:0051234;organic acid transport#GO:0015849;transport#GO:0006810;carboxylic acid transport#GO:0046942;lipid transport#GO:0006869;cellular process#GO:0009987;macromolecule localization#GO:0033036 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 secondary carrier transporter#PC00258;transporter#PC00227 HUMAN|HGNC=7650|UniProtKB=P41271 P41271 NBL1 PTHR15283:SF5 GREMLIN 1 NEUROBLASTOMA SUPPRESSOR OF TUMORIGENICITY 1 binding#GO:0005488;protein binding#GO:0005515;molecular function activator activity#GO:0140677;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;cytokine binding#GO:0019955;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=24224|UniProtKB=Q9NYV4 Q9NYV4 CDK12 PTHR24056:SF126 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE 12 phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of DNA-templated transcription, elongation#GO:0032786;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription elongation#GO:0032784;regulation of transcription elongation by RNA polymerase II#GO:0034243 organelle lumen#GO:0043233;transcription elongation factor complex#GO:0008023;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;protein-containing complex#GO:0032991;transferase complex#GO:1990234;protein kinase complex#GO:1902911;nuclear protein-containing complex#GO:0140513 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=4212|UniProtKB=Q9Y2T3 Q9Y2T3 GDA PTHR11271:SF6 GUANINE DEAMINASE GUANINE DEAMINASE hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;deaminase activity#GO:0019239;catalytic activity#GO:0003824;zinc ion binding#GO:0008270;metal ion binding#GO:0046872;hydrolase activity#GO:0016787;cation binding#GO:0043169;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;transition metal ion binding#GO:0046914 metabolic process#GO:0008152;purine nucleobase metabolic process#GO:0006144;purine nucleobase catabolic process#GO:0006145;purine-containing compound catabolic process#GO:0072523;nucleobase-containing small molecule metabolic process#GO:0055086;nucleobase metabolic process#GO:0009112;primary metabolic process#GO:0044238;cellular process#GO:0009987;purine-containing compound metabolic process#GO:0072521;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;nucleobase catabolic process#GO:0046113;nucleobase-containing compound metabolic process#GO:0006139 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 deaminase#PC00088 Purine metabolism#P02769>Guanine Deaminase#P03118;Xanthine and guanine salvage pathway#P02788>Guanine deaminase#P03249 HUMAN|HGNC=17906|UniProtKB=Q9BQ39 Q9BQ39 DDX50 PTHR47958:SF88 ATP-DEPENDENT RNA HELICASE DBP3 ATP-DEPENDENT RNA HELICASE DDX50 RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;ATP-dependent activity#GO:0140657;helicase activity#GO:0004386;catalytic activity, acting on RNA#GO:0140098;isomerase activity#GO:0016853;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;RNA helicase activity#GO:0003724;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543 organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 RNA helicase#PC00032 HUMAN|HGNC=4324|UniProtKB=P43220 P43220 GLP1R PTHR45620:SF25 PDF RECEPTOR-LIKE PROTEIN-RELATED GLUCAGON-LIKE PEPTIDE 1 RECEPTOR transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 regulation of biological quality#GO:0065008;cell communication#GO:0007154;circulatory system process#GO:0003013;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052;regulation of cellular process#GO:0050794;positive regulation of blood pressure#GO:0045777;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;system process#GO:0003008;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;blood circulation#GO:0008015;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of blood pressure#GO:0008217 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=6196|UniProtKB=Q92833 Q92833 JARID2 PTHR10694:SF149 LYSINE-SPECIFIC DEMETHYLASE PROTEIN JUMONJI dioxygenase activity#GO:0051213;histone modifying activity#GO:0140993;catalytic activity, acting on a protein#GO:0140096;demethylase activity#GO:0032451;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;oxidoreductase activity#GO:0016491;protein demethylase activity#GO:0140457;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;histone demethylase activity#GO:0032452 cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;chromatin organization#GO:0006325;chromatin remodeling#GO:0006338;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;cellular process#GO:0009987 intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229 histone modifying enzyme#PC00261 HUMAN|HGNC=27295|UniProtKB=Q5VWT5 Q5VWT5 FYB2 PTHR16830:SF1 SH2 CONTAINING ADAPTOR PRAM-1 RELATED FYN-BINDING PROTEIN 2 positive regulation of immune system process#GO:0002684;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;activation of immune response#GO:0002253;cellular process#GO:0009987;antigen receptor-mediated signaling pathway#GO:0050851;protein localization to cell periphery#GO:1990778;cell surface receptor signaling pathway#GO:0007166;immune response-activating signaling pathway#GO:0002757;protein localization to membrane#GO:0072657;integrin-mediated signaling pathway#GO:0007229;regulation of biological process#GO:0050789;immune response-regulating signaling pathway#GO:0002764;response to stimulus#GO:0050896;signaling#GO:0023052;immune system process#GO:0002376;cellular localization#GO:0051641;macromolecule localization#GO:0033036;positive regulation of response to stimulus#GO:0048584;immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007;T cell receptor signaling pathway#GO:0050852;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;intracellular protein localization#GO:0008104;protein localization to plasma membrane#GO:0072659;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;immune response-activating cell surface receptor signaling pathway#GO:0002429;localization within membrane#GO:0051668;regulation of immune response#GO:0050776;cell communication#GO:0007154;localization#GO:0051179 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HUMAN|HGNC=10799|UniProtKB=Q8IWL1 Q8IWL1 SFTPA2 PTHR24024:SF40 PULMONARY SURFACTANT-ASSOCIATED PROTEIN A PULMONARY SURFACTANT-ASSOCIATED PROTEIN A2 signaling receptor activity#GO:0038023;pattern recognition receptor activity#GO:0038187;molecular transducer activity#GO:0060089 regulation of transport#GO:0051049;regulation of localization#GO:0032879;regulation of endocytosis#GO:0030100;immune effector process#GO:0002252;humoral immune response#GO:0006959;defense response to other organism#GO:0098542;activation of immune response#GO:0002253;positive regulation of biological process#GO:0048518;defense response to symbiont#GO:0140546;positive regulation of transport#GO:0051050;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;positive regulation of immune system process#GO:0002684;positive regulation of cellular component organization#GO:0051130;immune system process#GO:0002376;biological process involved in interspecies interaction between organisms#GO:0044419;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;response to external stimulus#GO:0009605;defense response#GO:0006952;innate immune response#GO:0045087;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;biological regulation#GO:0065007;response to other organism#GO:0051707;positive regulation of response to stimulus#GO:0048584;positive regulation of endocytosis#GO:0045807;positive regulation of cellular process#GO:0048522;immune response#GO:0006955;complement activation#GO:0006956;regulation of immune response#GO:0050776;response to external biotic stimulus#GO:0043207;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 structural protein#PC00211;surfactant#PC00212 HUMAN|HGNC=16647|UniProtKB=O00574 O00574 CXCR6 PTHR10489:SF705 CELL ADHESION MOLECULE C-X-C CHEMOKINE RECEPTOR TYPE 6 molecular transducer activity#GO:0060089;protein binding#GO:0005515;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888;G protein-coupled receptor activity#GO:0004930;immune receptor activity#GO:0140375;cytokine binding#GO:0019955;signaling receptor activity#GO:0038023;cytokine receptor activity#GO:0004896 regulation of biological quality#GO:0065008;intracellular signal transduction#GO:0035556;cell chemotaxis#GO:0060326;cell communication#GO:0007154;chemotaxis#GO:0006935;immune system process#GO:0002376;cellular response to chemical stimulus#GO:0070887;positive regulation of cytosolic calcium ion concentration#GO:0007204;locomotion#GO:0040011;signaling#GO:0023052;regulation of cellular process#GO:0050794;cell motility#GO:0048870;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;calcium-mediated signaling#GO:0019722;response to external stimulus#GO:0009605;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;cell migration#GO:0016477;response to chemical#GO:0042221;taxis#GO:0042330;cellular process#GO:0009987;signal transduction#GO:0007165;immune response#GO:0006955 membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cell adhesion molecule#PC00069 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CHKR#P00854 HUMAN|HGNC=25154|UniProtKB=Q96EX1 Q96EX1 SMIM12 PTHR28599:SF2 SMALL INTEGRAL MEMBRANE PROTEIN 12 SMALL INTEGRAL MEMBRANE PROTEIN 12 HUMAN|HGNC=23294|UniProtKB=Q5T681 Q5T681 C10orf62 PTHR23008:SF0 CHROMOSOME 28 C10ORF62 HOMOLOG CHROMOSOME 10 OPEN READING FRAME 62 HUMAN|HGNC=23217|UniProtKB=Q9NS71 Q9NS71 GKN1 PTHR16483:SF1 GASTROKINE 1 GASTROKINE-1 regulation of cellular process#GO:0050794;regulation of cell population proliferation#GO:0042127;biological regulation#GO:0065007;regulation of biological process#GO:0050789 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=28178|UniProtKB=Q96NT0 Q96NT0 VMA22 PTHR31996:SF2 COILED-COIL DOMAIN-CONTAINING PROTEIN 115 VACUOLAR ATPASE ASSEMBLY PROTEIN VMA22 regulation of intracellular pH#GO:0051453;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;chemical homeostasis#GO:0048878;regulation of pH#GO:0006885;intracellular chemical homeostasis#GO:0055082;regulation of biological quality#GO:0065008;cellular homeostasis#GO:0019725;vacuolar acidification#GO:0007035;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion homeostasis#GO:0050801;homeostatic process#GO:0042592;biological regulation#GO:0065007 membrane protein complex#GO:0098796;cation-transporting ATPase complex#GO:0090533;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;ATPase complex#GO:1904949;catalytic complex#GO:1902494;vacuolar proton-transporting V-type ATPase complex#GO:0016471;intracellular organelle#GO:0043229;transmembrane transporter complex#GO:1902495;ATPase dependent transmembrane transport complex#GO:0098533;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;vacuole#GO:0005773;proton-transporting two-sector ATPase complex#GO:0016469;endoplasmic reticulum#GO:0005783;vacuolar membrane#GO:0005774;transporter complex#GO:1990351;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;proton-transporting V-type ATPase complex#GO:0033176 HUMAN|HGNC=2666|UniProtKB=Q14118 Q14118 DAG1 PTHR21559:SF22 DYSTROGLYCAN-RELATED DYSTROGLYCAN 1 cell adhesion molecule binding#GO:0050839;cell adhesion mediator activity#GO:0098631;binding#GO:0005488;protein binding#GO:0005515 system development#GO:0048731;anatomical structure development#GO:0048856;tissue morphogenesis#GO:0048729;muscle structure development#GO:0061061;muscle cell differentiation#GO:0042692;muscle cell development#GO:0055001;neurogenesis#GO:0022008;neuron projection guidance#GO:0097485;cellular developmental process#GO:0048869;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;plasma membrane bounded cell projection organization#GO:0120036;tissue development#GO:0009888;multicellular organismal process#GO:0032501;epithelium development#GO:0060429;axon development#GO:0061564;axon guidance#GO:0007411;neuron development#GO:0048666;axonogenesis#GO:0007409;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;cell differentiation#GO:0030154;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;morphogenesis of an epithelium#GO:0002009;cell projection morphogenesis#GO:0048858;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;cellular process#GO:0009987;neuron projection development#GO:0031175 synapse#GO:0045202;cellular anatomical structure#GO:0110165;membrane protein complex#GO:0098796;postsynapse#GO:0098794;basement membrane#GO:0005604;plasma membrane protein complex#GO:0098797;extracellular region#GO:0005576;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;membrane#GO:0016020;dystrophin-associated glycoprotein complex#GO:0016010;cell periphery#GO:0071944;cell junction#GO:0030054;sarcolemma#GO:0042383 cell adhesion molecule#PC00069 HUMAN|HGNC=8556|UniProtKB=Q9H361 Q9H361 PABPC3 PTHR24012:SF680 RNA BINDING PROTEIN POLYADENYLATE-BINDING PROTEIN 3 poly(A) binding#GO:0008143;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;mRNA 3'-UTR binding#GO:0003730;single-stranded RNA binding#GO:0003727;RNA binding#GO:0003723 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;post-transcriptional regulation of gene expression#GO:0010608;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 nucleus#GO:0005634;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;cytoplasmic stress granule#GO:0010494;membraneless organelle#GO:0043228;intracellular membrane-bounded organelle#GO:0043231;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 RNA metabolism protein#PC00031 HUMAN|HGNC=1595|UniProtKB=Q14094 Q14094 CCNI PTHR10177:SF187 CYCLINS CYCLIN-I enzyme regulator activity#GO:0030234;cyclin-dependent protein kinase regulator activity#GO:0019914;protein kinase regulator activity#GO:0019887;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538 mitotic cell cycle phase transition#GO:0044772;G1/S transition of mitotic cell cycle#GO:0000082;mitotic cell cycle process#GO:1903047;cell cycle#GO:0007049;cell cycle G1/S phase transition#GO:0044843;cell cycle process#GO:0022402;cellular process#GO:0009987;mitotic cell cycle#GO:0000278;cell cycle phase transition#GO:0044770 transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554;intracellular anatomical structure#GO:0005622;protein kinase complex#GO:1902911;nucleus#GO:0005634;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 kinase activator#PC00138 HUMAN|HGNC=24834|UniProtKB=Q5JY77 Q5JY77 GPRASP1 PTHR46414:SF3 PROTEIN BHLHB9-RELATED G PROTEIN-COUPLED RECEPTOR-ASSOCIATED SORTING PROTEIN 1 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;cytosol#GO:0005829;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=11745|UniProtKB=Q01664 Q01664 TFAP4 PTHR15741:SF27 BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR TRANSCRIPTION FACTOR AP-4 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 DNA-binding transcription factor#PC00218 HUMAN|HGNC=2464|UniProtKB=P13611 P13611 VCAN PTHR22804:SF6 AGGRECAN/VERSICAN PROTEOGLYCAN VERSICAN CORE PROTEIN central nervous system development#GO:0007417;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502;skeletal system development#GO:0001501;multicellular organism development#GO:0007275;anatomical structure development#GO:0048856;system development#GO:0048731 extracellular region#GO:0005576;cell junction#GO:0030054;cell periphery#GO:0071944;membrane#GO:0016020;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;plasma membrane#GO:0005886;synapse#GO:0045202;cellular anatomical structure#GO:0110165 extracellular matrix protein#PC00102;extracellular matrix glycoprotein#PC00100 HUMAN|HGNC=16341|UniProtKB=Q96P88 Q96P88 GNRHR2 PTHR24241:SF69 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR GONADOTROPIN-RELEASING HORMONE II RECEPTOR-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;cellular process#GO:0009987;response to hormone#GO:0009725;biological regulation#GO:0065007;response to chemical#GO:0042221;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to endogenous stimulus#GO:0009719;signaling#GO:0023052;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;cellular response to hormone stimulus#GO:0032870;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GsPCR#P00720;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GqPCR#P00730 HUMAN|HGNC=15456|UniProtKB=Q14703 Q14703 MBTPS1 PTHR43806:SF7 PEPTIDASE S8 MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE-1 PROTEASE hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;serine-type peptidase activity#GO:0008236;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity#GO:0003824 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 serine protease#PC00203 HUMAN|HGNC=26407|UniProtKB=Q3MHD2 Q3MHD2 LSM12 PTHR13542:SF0 LSM12 HOMOLOG PROTEIN LSM12 HUMAN|HGNC=8666|UniProtKB=Q9UN75 Q9UN75 PCDHA12 PTHR24028:SF76 CADHERIN-87A PROTOCADHERIN ALPHA-12 cellular process#GO:0009987;cell adhesion#GO:0007155 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 cadherin#PC00057;cell adhesion molecule#PC00069 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HUMAN|HGNC=26465|UniProtKB=Q7Z739 Q7Z739 YTHDF3 PTHR12357:SF9 YTH YT521-B HOMOLOGY DOMAIN-CONTAINING YTH DOMAIN-CONTAINING FAMILY PROTEIN 3 RNA binding#GO:0003723;molecular adaptor activity#GO:0060090;mRNA binding#GO:0003729;protein-macromolecule adaptor activity#GO:0030674;nucleic acid binding#GO:0003676;binding#GO:0005488;protein-RNA adaptor activity#GO:0140517 positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;negative regulation of macromolecule biosynthetic process#GO:0010558;RNA destabilization#GO:0050779;regulation of mRNA metabolic process#GO:1903311;positive regulation of mRNA metabolic process#GO:1903313;mRNA destabilization#GO:0061157;negative regulation of metabolic process#GO:0009892;regulation of mRNA stability#GO:0043488;regulation of biological process#GO:0050789;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of biological quality#GO:0065008;positive regulation of metabolic process#GO:0009893;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;regulation of biosynthetic process#GO:0009889;positive regulation of catabolic process#GO:0009896;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of mRNA catabolic process#GO:0061014;regulation of RNA metabolic process#GO:0051252;regulation of RNA stability#GO:0043487 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 RNA metabolism protein#PC00031 HUMAN|HGNC=18012|UniProtKB=A0A024RBG1 A0A024RBG1 NUDT4B PTHR12629:SF6 DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE 2-RELATED hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818 small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;nucleoside phosphate catabolic process#GO:1901292;nucleoside phosphate metabolic process#GO:0006753;small molecule catabolic process#GO:0044282;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;organophosphate catabolic process#GO:0046434;nucleotide metabolic process#GO:0009117;nucleobase-containing compound metabolic process#GO:0006139;organophosphate metabolic process#GO:0019637;nucleobase-containing compound catabolic process#GO:0034655;cellular process#GO:0009987;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;alcohol metabolic process#GO:0006066;nucleotide catabolic process#GO:0009166 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 phosphatase#PC00181 HUMAN|HGNC=30825|UniProtKB=Q8NFZ8 Q8NFZ8 CADM4 PTHR45889:SF3 IG-LIKE DOMAIN-CONTAINING PROTEIN CELL ADHESION MOLECULE 4 growth factor receptor binding#GO:0070851;signaling receptor binding#GO:0005102;cytokine receptor binding#GO:0005126;binding#GO:0005488;protein binding#GO:0005515 cell-cell adhesion#GO:0098609;regulation of response to wounding#GO:1903034;homophilic cell-cell adhesion#GO:0007156;cellular process#GO:0009987;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of response to stress#GO:0080134;regulation of response to stimulus#GO:0048583;regulation of small GTPase mediated signal transduction#GO:0051056;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of wound healing#GO:0061041;regulation of cell communication#GO:0010646;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;cell adhesion#GO:0007155 cell junction#GO:0030054;cellular anatomical structure#GO:0110165;cell-cell contact zone#GO:0044291;anchoring junction#GO:0070161;cell-cell junction#GO:0005911 HUMAN|HGNC=29223|UniProtKB=Q9ULJ7 Q9ULJ7 ANKRD50 PTHR24123:SF65 ANKYRIN REPEAT-CONTAINING ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 50 localization within membrane#GO:0051668;transport#GO:0006810;intracellular transport#GO:0046907;vesicle-mediated transport to the plasma membrane#GO:0098876;endosomal transport#GO:0016197;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;endocytic recycling#GO:0032456;vesicle-mediated transport#GO:0016192 scaffold/adaptor protein#PC00226 HUMAN|HGNC=8907|UniProtKB=O95394 O95394 PGM3 PTHR45955:SF5 PHOSPHOACETYLGLUCOSAMINE MUTASE PHOSPHOACETYLGLUCOSAMINE MUTASE isomerase activity#GO:0016853;intramolecular phosphotransferase activity#GO:0016868;intramolecular transferase activity#GO:0016866;catalytic activity#GO:0003824 metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;developmental process#GO:0032502;nucleoside phosphate biosynthetic process#GO:1901293;cellular developmental process#GO:0048869;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;organophosphate metabolic process#GO:0019637;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;hemopoiesis#GO:0030097;nucleotide-sugar metabolic process#GO:0009225;UDP-N-acetylglucosamine biosynthetic process#GO:0006048;anatomical structure development#GO:0048856;UDP-N-acetylglucosamine metabolic process#GO:0006047;organophosphate biosynthetic process#GO:0090407;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;cell differentiation#GO:0030154;small molecule metabolic process#GO:0044281;amino sugar metabolic process#GO:0006040;cell development#GO:0048468;nucleoside phosphate metabolic process#GO:0006753 mutase#PC00160;isomerase#PC00135 HUMAN|HGNC=17357|UniProtKB=Q9HC16 Q9HC16 APOBEC3G PTHR13857:SF20 MRNA EDITING ENZYME DNA DC-DU-EDITING ENZYME APOBEC-3G catalytic activity#GO:0003824;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;deaminase activity#GO:0019239;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;nucleic acid binding#GO:0003676;binding#GO:0005488;hydrolase activity#GO:0016787;RNA binding#GO:0003723 regulation of RNA metabolic process#GO:0051252;response to virus#GO:0009615;macromolecule modification#GO:0043412;response to external biotic stimulus#GO:0043207;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;nucleic acid metabolic process#GO:0090304;cytidine to uridine editing#GO:0016554;primary metabolic process#GO:0044238;response to external stimulus#GO:0009605;defense response#GO:0006952;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;negative regulation of cellular process#GO:0048523;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;response to other organism#GO:0051707;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;base conversion or substitution editing#GO:0016553;RNA metabolic process#GO:0016070;RNA modification#GO:0009451;biological process involved in interspecies interaction between organisms#GO:0044419;negative regulation of metabolic process#GO:0009892;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;defense response to virus#GO:0051607;negative regulation of biological process#GO:0048519;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;response to biotic stimulus#GO:0009607;response to stress#GO:0006950 membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;P-body#GO:0000932;intracellular organelle#GO:0043229;organelle#GO:0043226;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 RNA processing factor#PC00147 HUMAN|HGNC=26098|UniProtKB=Q96EN9 Q96EN9 REX1BD PTHR28309:SF1 REQUIRED FOR EXCISION 1-B DOMAIN-CONTAINING PROTEIN REQUIRED FOR EXCISION 1-B DOMAIN-CONTAINING PROTEIN HUMAN|HGNC=29534|UniProtKB=Q9BSJ8 Q9BSJ8 ESYT1 PTHR45761:SF3 EXTENDED SYNAPTOTAGMIN-LIKE PROTEIN 2, ISOFORM C EXTENDED SYNAPTOTAGMIN-1 phospholipid binding#GO:0005543;phosphatidylinositol binding#GO:0035091;phosphatidylcholine binding#GO:0031210;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;binding#GO:0005488;lipid binding#GO:0008289;cation binding#GO:0043169;metal ion binding#GO:0046872 organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;membrane#GO:0016020 membrane traffic protein#PC00150;membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=232|UniProtKB=Q08828 Q08828 ADCY1 PTHR45627:SF26 ADENYLATE CYCLASE TYPE 1 ADENYLATE CYCLASE TYPE 1 cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824;adenylate cyclase activity#GO:0004016;lyase activity#GO:0016829 cyclic nucleotide metabolic process#GO:0009187;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;nucleoside phosphate biosynthetic process#GO:1901293;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;carbohydrate derivative metabolic process#GO:1901135;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;biosynthetic process#GO:0009058;cell communication#GO:0007154;organophosphate biosynthetic process#GO:0090407;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;nucleoside phosphate metabolic process#GO:0006753;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing compound biosynthetic process#GO:0034654;cyclic purine nucleotide metabolic process#GO:0052652;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;ribose phosphate biosynthetic process#GO:0046390;signal transduction#GO:0007165;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;G protein-coupled receptor signaling pathway#GO:0007186;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;ribonucleotide metabolic process#GO:0009259;cyclic nucleotide biosynthetic process#GO:0009190;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;nucleotide biosynthetic process#GO:0009165;phosphorus metabolic process#GO:0006793;purine nucleotide metabolic process#GO:0006163;regulation of biological process#GO:0050789;purine-containing compound metabolic process#GO:0072521;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;signaling#GO:0023052 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 adenylate cyclase#PC00043 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>cAMP cyclase#P00719;CCKR signaling map#P06959>Adenylate cyclase#P07127;Gonadotropin-releasing hormone receptor pathway#P06664>AC#P06699;Endothelin signaling pathway#P00019>Adenylate cyclase#P00569;GABA-B receptor II signaling#P05731>AC#P05760 HUMAN|HGNC=2135|UniProtKB=Q86WG5 Q86WG5 SBF2 PTHR10807:SF4 MYOTUBULARIN-RELATED MYOTUBULARIN-RELATED PROTEIN 13 hydrolase activity#GO:0016787;enzyme regulator activity#GO:0030234;guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;phosphoric ester hydrolase activity#GO:0042578;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;phosphate-containing compound metabolic process#GO:0006796;phospholipid dephosphorylation#GO:0046839;glycerophospholipid metabolic process#GO:0006650;glycerolipid metabolic process#GO:0046486;phospholipid metabolic process#GO:0006644;phosphatidylinositol dephosphorylation#GO:0046856;metabolic process#GO:0008152;phosphatidylinositol metabolic process#GO:0046488;lipid metabolic process#GO:0006629;dephosphorylation#GO:0016311;lipid modification#GO:0030258 membrane#GO:0016020;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 phosphatase#PC00181 HUMAN|HGNC=51253|UniProtKB=A0A087WXM9 A0A087WXM9 MEIKIN PTHR38006:SF1 MEIOSIS-SPECIFIC KINETOCHORE PROTEIN MEIOSIS-SPECIFIC KINETOCHORE PROTEIN meiotic sister chromatid cohesion#GO:0051177;chromosome organization#GO:0051276;meiotic chromosome segregation#GO:0045132;cellular component organization or biogenesis#GO:0071840;homologous chromosome segregation#GO:0045143;meiotic nuclear division#GO:0140013;chromosome segregation#GO:0007059;meiotic cell cycle#GO:0051321;male meiotic nuclear division#GO:0007140;male gamete generation#GO:0048232;cellular process#GO:0009987;organelle organization#GO:0006996;multicellular organismal reproductive process#GO:0048609;organelle fission#GO:0048285;sister chromatid cohesion#GO:0007062;sexual reproduction#GO:0019953;meiosis I cell cycle process#GO:0061982;nuclear division#GO:0000280;reproductive process#GO:0022414;gamete generation#GO:0007276;cell cycle process#GO:0022402;cell cycle#GO:0007049;nuclear chromosome segregation#GO:0098813;meiotic cell cycle process#GO:1903046;meiosis I#GO:0007127;cellular component organization#GO:0016043 HUMAN|HGNC=20778|UniProtKB=P07437 P07437 TUBB PTHR11588:SF61 TUBULIN TUBULIN BETA CHAIN small molecule binding#GO:0036094;anion binding#GO:0043168;ion binding#GO:0043167;structural molecule activity#GO:0005198;nucleotide binding#GO:0000166;binding#GO:0005488;structural constituent of cytoskeleton#GO:0005200;nucleoside phosphate binding#GO:1901265;guanyl nucleotide binding#GO:0019001;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555 organelle organization#GO:0006996;cell cycle#GO:0007049;cellular component organization#GO:0016043;cellular process#GO:0009987;mitotic cell cycle#GO:0000278;cytoskeleton organization#GO:0007010;cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226;microtubule-based process#GO:0007017 organelle#GO:0043226;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630;microtubule#GO:0005874;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 tubulin#PC00228;cytoskeletal protein#PC00085 Huntington disease#P00029>beta-Tubulin#P00790;Cytoskeletal regulation by Rho GTPase#P00016>tubulin#P00526;Huntington disease#P00029>Microtubule#P00780 HUMAN|HGNC=11921|UniProtKB=O95407 O95407 TNFRSF6B PTHR23097:SF116 TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 6B transmembrane signal receptor#PC00197 HUMAN|HGNC=11521|UniProtKB=Q9UHF0 Q9UHF0 TAC3 PTHR15536:SF1 TACHYKININ-3 TACHYKININ-3 multicellular organismal process#GO:0032501;blood circulation#GO:0008015;positive regulation of blood pressure#GO:0045777;biological regulation#GO:0065007;regulation of blood pressure#GO:0008217;regulation of biological quality#GO:0065008;system process#GO:0003008;circulatory system process#GO:0003013 HUMAN|HGNC=12187|UniProtKB=A0A1B0GX78 A0A1B0GX78 TRBV12-5 PTHR23268:SF91 T-CELL RECEPTOR BETA CHAIN T CELL RECEPTOR BETA VARIABLE 12-5 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=19972|UniProtKB=Q96JQ2 Q96JQ2 CLMN PTHR47535:SF7 MUSCLE-SPECIFIC PROTEIN 300 KDA, ISOFORM G CALMIN actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;actin filament binding#GO:0051015;binding#GO:0005488;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 regulation of cell population proliferation#GO:0042127;localization#GO:0051179;cellular localization#GO:0051641;organelle localization#GO:0051640;establishment of organelle localization#GO:0051656;regulation of cellular process#GO:0050794;nuclear migration#GO:0007097;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;establishment of localization#GO:0051234;transport#GO:0006810;negative regulation of cellular process#GO:0048523;intracellular transport#GO:0046907;biological regulation#GO:0065007;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;negative regulation of cell population proliferation#GO:0008285 membrane protein complex#GO:0098796;organelle envelope#GO:0031967;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;outer membrane#GO:0019867;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;nucleus#GO:0005634;endomembrane system#GO:0012505;organelle outer membrane#GO:0031968;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;nuclear envelope#GO:0005635;nuclear protein-containing complex#GO:0140513;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;nuclear membrane#GO:0031965 HUMAN|HGNC=28617|UniProtKB=Q8N350 Q8N350 CBARP PTHR28597:SF1 VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT-ASSOCIATED REGULATORY PROTEIN VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT-ASSOCIATED REGULATORY PROTEIN binding#GO:0005488;transmembrane transporter binding#GO:0044325;protein binding#GO:0005515 regulation of transport#GO:0051049;regulation of localization#GO:0032879;regulation of exocytosis#GO:0017157;regulation of secretion by cell#GO:1903530;regulation of secretion#GO:0051046;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;negative regulation of transport#GO:0051051;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;negative regulation of biological process#GO:0048519 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 ion channel#PC00133;voltage-gated ion channel#PC00241 HUMAN|HGNC=7160|UniProtKB=P50281 P50281 MMP14 PTHR10201:SF24 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE-14 metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 biosynthetic process#GO:0009058;multicellular organismal process#GO:0032501;protein maturation#GO:0051604;gene expression#GO:0010467;cellular process#GO:0009987;protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;developmental process#GO:0032502;metabolic process#GO:0008152;catabolic process#GO:0009056;zymogen activation#GO:0031638;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;system development#GO:0048731;external encapsulating structure organization#GO:0045229;skeletal system development#GO:0001501;protein metabolic process#GO:0019538;anatomical structure development#GO:0048856;extracellular matrix organization#GO:0030198;proteolysis#GO:0006508;animal gross anatomical part developmental process#GO:0160108;extracellular structure organization#GO:0043062 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;extracellular region#GO:0005576 metalloprotease#PC00153 Gonadotropin-releasing hormone receptor pathway#P06664>MT1-MMP#P06716;Alzheimer disease-presenilin pathway#P00004>Membrane metalloprotease#P00141;Alzheimer disease-presenilin pathway#P00004>Matrix metalloprotease#P00130 HUMAN|HGNC=28959|UniProtKB=Q14008 Q14008 CKAP5 PTHR12609:SF0 MICROTUBULE ASSOCIATED PROTEIN XMAP215 CYTOSKELETON-ASSOCIATED PROTEIN 5 transferase activity#GO:0016740;catalytic activity#GO:0003824;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;catalytic activity, acting on a protein#GO:0140096;binding#GO:0005488;microtubule binding#GO:0008017;protein binding#GO:0005515 spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;microtubule polymerization#GO:0046785;centrosome duplication#GO:0051298;microtubule-based process#GO:0007017;protein-containing complex organization#GO:0043933;microtubule organizing center organization#GO:0031023;mitotic cell cycle process#GO:1903047;microtubule polymerization or depolymerization#GO:0031109;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;establishment or maintenance of cell polarity#GO:0007163;microtubule cytoskeleton organization#GO:0000226;supramolecular fiber organization#GO:0097435;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cellular component organization#GO:0016043;cell cycle#GO:0007049;cell cycle process#GO:0022402;centrosome cycle#GO:0007098;protein-containing complex assembly#GO:0065003;protein polymerization#GO:0051258;mitotic spindle organization#GO:0007052;mitotic cell cycle#GO:0000278 microtubule#GO:0005874;supramolecular fiber#GO:0099512;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;spindle pole#GO:0000922;chromosome#GO:0005694;kinetochore#GO:0000776;microtubule end#GO:1990752;microtubule plus-end#GO:0035371;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;microtubule organizing center#GO:0005815;centrosome#GO:0005813;spindle#GO:0005819;cytoskeleton#GO:0005856;chromosome, centromeric region#GO:0000775;condensed chromosome#GO:0000793;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;condensed chromosome, centromeric region#GO:0000779 non-motor microtubule binding protein#PC00166 HUMAN|HGNC=11345|UniProtKB=O95980 O95980 RECK PTHR13487:SF3 SERINE PROTEASE INHIBITOR REVERSION-INDUCING CYSTEINE-RICH PROTEIN WITH KAZAL MOTIFS enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;peptidase regulator activity#GO:0061134;endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772;enzyme inhibitor activity#GO:0004857 regulation of signaling#GO:0023051;sprouting angiogenesis#GO:0002040;animal gross anatomical part developmental process#GO:0160108;extracellular structure organization#GO:0043062;angiogenesis#GO:0001525;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;blood vessel morphogenesis#GO:0048514;cellular component organization#GO:0016043;regulation of Wnt signaling pathway#GO:0030111;circulatory system development#GO:0072359;anatomical structure formation involved in morphogenesis#GO:0048646;vasculature development#GO:0001944;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;regulation of canonical Wnt signaling pathway#GO:0060828;external encapsulating structure organization#GO:0045229;system development#GO:0048731;anatomical structure development#GO:0048856;extracellular matrix organization#GO:0030198;anatomical structure maturation#GO:0071695;tube morphogenesis#GO:0035239;blood vessel development#GO:0001568;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;developmental process#GO:0032502;regulation of response to stimulus#GO:0048583;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;tube development#GO:0035295;developmental maturation#GO:0021700;multicellular organismal process#GO:0032501 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 protease inhibitor#PC00191;protein-binding activity modulator#PC00095 HUMAN|HGNC=9651|UniProtKB=Q16825 Q16825 PTPN21 PTHR45706:SF3 TYROSINE-PROTEIN PHOSPHATASE TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 21 phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096 regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of hippo signaling#GO:0035330;regulation of cell communication#GO:0010646;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789;positive regulation of signaling#GO:0023056;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;positive regulation of response to stimulus#GO:0048584;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583 protein phosphatase#PC00195 HUMAN|HGNC=18858|UniProtKB=Q9H3S5 Q9H3S5 PIGM PTHR12886:SF0 PIG-M MANNOSYLTRANSFERASE GPI ALPHA-1,4-MANNOSYLTRANSFERASE I, CATALYTIC SUBUNIT catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758;glycosyltransferase activity#GO:0016757;mannosyltransferase activity#GO:0000030 protein metabolic process#GO:0019538;organophosphate biosynthetic process#GO:0090407;glycolipid biosynthetic process#GO:0009247;phospholipid biosynthetic process#GO:0008654;glycolipid metabolic process#GO:0006664;glycerolipid metabolic process#GO:0046486;liposaccharide metabolic process#GO:1903509;GPI anchored protein biosynthesis#GO:0180046;phospholipid metabolic process#GO:0006644;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474;GPI anchor metabolic process#GO:0006505;lipid biosynthetic process#GO:0008610;gene expression#GO:0010467;protein maturation#GO:0051604;GPI anchor biosynthetic process#GO:0006506;glycerophospholipid metabolic process#GO:0006650;biosynthetic process#GO:0009058;organophosphate metabolic process#GO:0019637;glycerolipid biosynthetic process#GO:0045017;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mannosyltransferase complex#GO:0031501;endoplasmic reticulum protein-containing complex#GO:0140534;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 glycosyltransferase#PC00111 HUMAN|HGNC=12829|UniProtKB=O43543 O43543 XRCC2 PTHR46644:SF4 DNA REPAIR PROTEIN XRCC2 DNA REPAIR PROTEIN XRCC2 DNA binding#GO:0003677;four-way junction DNA binding#GO:0000400;binding#GO:0005488;nucleic acid binding#GO:0003676 DNA recombination#GO:0006310;DNA damage response#GO:0006974;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;response to stress#GO:0006950;nucleobase-containing compound metabolic process#GO:0006139;cellular response to stress#GO:0033554;recombinational repair#GO:0000725;cellular response to stimulus#GO:0051716;double-strand break repair via homologous recombination#GO:0000724;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;response to stimulus#GO:0050896 protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;nucleus#GO:0005634;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;cytoskeleton#GO:0005856;centrosome#GO:0005813;microtubule organizing center#GO:0005815;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;replication fork#GO:0005657;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 DNA metabolism protein#PC00009 HUMAN|HGNC=5023|UniProtKB=P55318 P55318 FOXA3 PTHR11829:SF201 FORKHEAD BOX PROTEIN HEPATOCYTE NUCLEAR FACTOR 3-GAMMA sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;developmental process#GO:0032502;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 winged helix/forkhead transcription factor#PC00246;gene-specific transcriptional regulator#PC00264;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=4237|UniProtKB=Q99684 Q99684 GFI1 PTHR24404:SF46 ZINC FINGER PROTEIN ZINC FINGER PROTEIN GFI-1 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 DNA-binding transcription factor#PC00218;zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=1623|UniProtKB=P50990 P50990 CCT8 PTHR11353:SF78 CHAPERONIN T-COMPLEX PROTEIN 1 SUBUNIT THETA primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;protein maturation#GO:0051604;protein folding#GO:0006457;biosynthetic process#GO:0009058;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 protein folding chaperone complex#GO:0101031;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;chaperonin-containing T-complex#GO:0005832;cytosol#GO:0005829;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 chaperonin#PC00073 HUMAN|HGNC=9259|UniProtKB=P30405 P30405 PPIF PTHR11071:SF408 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE F, MITOCHONDRIAL cellular response to stress#GO:0033554;response to oxygen-containing compound#GO:1901700;cellular response to chemical stimulus#GO:0070887;regulation of biological quality#GO:0065008;cellular response to stimulus#GO:0051716;cell death#GO:0008219;programmed cell death#GO:0012501;response to stimulus#GO:0050896;response to reactive oxygen species#GO:0000302;cellular response to chemical stress#GO:0062197;response to oxidative stress#GO:0006979;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987;response to stress#GO:0006950;biological regulation#GO:0065007;regulation of mitochondrial membrane permeability#GO:0046902;response to chemical#GO:0042221;regulation of membrane permeability#GO:0090559;cellular response to oxidative stress#GO:0034599 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;organelle envelope#GO:0031967;membrane#GO:0016020;mitochondrion#GO:0005739;mitochondrial envelope#GO:0005740;nucleus#GO:0005634 chaperone#PC00072 HUMAN|HGNC=51617|UniProtKB=P0DN25 P0DN25 C1GALT1C1L PTHR23033:SF38 BETA1,3-GALACTOSYLTRANSFERASE C1GALT1-SPECIFIC CHAPERONE 1-LIKE PROTEIN galactosyltransferase activity#GO:0008378;glycosyltransferase activity#GO:0016757;catalytic activity, acting on a protein#GO:0140096;UDP-glycosyltransferase activity#GO:0008194;hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;catalytic activity#GO:0003824 transferase#PC00220 HUMAN|HGNC=3200|UniProtKB=Q5VTE0 Q5VTE0 EEF1A1P5 PTHR23115:SF222 TRANSLATION FACTOR ELONGATION FACTOR 1-ALPHA 1-RELATED hydrolase activity#GO:0016787;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;translation elongation factor activity#GO:0003746;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817;translation factor activity#GO:0180051 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;translational elongation#GO:0006414;translation#GO:0006412;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 translation factor#PC00223 HUMAN|HGNC=18810|UniProtKB=Q96P56 Q96P56 CATSPER2 PTHR46923:SF1 CATION CHANNEL SPERM-ASSOCIATED PROTEIN 2 CATION CHANNEL SPERM-ASSOCIATED PROTEIN 2 spermatogenesis#GO:0007283;developmental process#GO:0032502;flagellated sperm motility#GO:0030317;microtubule-based process#GO:0007017;cellular developmental process#GO:0048869;cell maturation#GO:0048469;cellular process#GO:0009987;cilium movement involved in cell motility#GO:0060294;sperm capacitation#GO:0048240;male gamete generation#GO:0048232;developmental maturation#GO:0021700;spermatid development#GO:0007286;cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;sexual reproduction#GO:0019953;spermatid differentiation#GO:0048515;multicellular organismal reproductive process#GO:0048609;anatomical structure development#GO:0048856;cilium-dependent cell motility#GO:0060285;sperm motility#GO:0097722;germ cell development#GO:0007281;anatomical structure maturation#GO:0071695;developmental process involved in reproduction#GO:0003006;reproductive process#GO:0022414;cell development#GO:0048468;fertilization#GO:0009566;cellular process involved in reproduction in multicellular organism#GO:0022412;microtubule-based movement#GO:0007018;cell motility#GO:0048870;gamete generation#GO:0007276;cell differentiation#GO:0030154 transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cation channel complex#GO:0034703;plasma membrane#GO:0005886;monoatomic ion channel complex#GO:0034702;CatSper complex#GO:0036128;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;calcium channel complex#GO:0034704;membrane#GO:0016020;voltage-gated calcium channel complex#GO:0005891;membrane protein complex#GO:0098796 transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=4336|UniProtKB=P49448 P49448 GLUD2 PTHR11606:SF15 GLUTAMATE DEHYDROGENASE GLUTAMATE DEHYDROGENASE 2, MITOCHONDRIAL catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;proteinogenic amino acid metabolic process#GO:0170039;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;amino acid metabolic process#GO:0006520;small molecule catabolic process#GO:0044282;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 Glutamine glutamate conversion#P02745>Glutamate Dehydrogenase#P02967 HUMAN|HGNC=22442|UniProtKB=Q2UY09 Q2UY09 COL28A1 PTHR24023:SF878 COLLAGEN ALPHA COLLAGEN ALPHA-1(XXVIII) CHAIN structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 external encapsulating structure organization#GO:0045229;cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;cellular process#GO:0009987;extracellular structure organization#GO:0043062;cellular component organization#GO:0016043 external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HUMAN|HGNC=20597|UniProtKB=P61960 P61960 UFM1 PTHR15825:SF5 UBIQUITIN-FOLD MODIFIER 1 UBIQUITIN-FOLD MODIFIER 1 response to stimulus#GO:0050896;catabolic process#GO:0009056;macroautophagy#GO:0016236;reticulophagy#GO:0061709;response to stress#GO:0006950;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;autophagy#GO:0006914;process utilizing autophagic mechanism#GO:0061919;response to endoplasmic reticulum stress#GO:0034976;metabolic process#GO:0008152;cellular response to stress#GO:0033554 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=15446|UniProtKB=Q8WWY3 Q8WWY3 PRPF31 PTHR13904:SF0 PRE-MRNA SPLICING FACTOR PRP31 U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP31 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;mRNA splicing, via spliceosome#GO:0000398;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375 cellular anatomical structure#GO:0110165;organelle#GO:0043226;U4 snRNP#GO:0005687;intracellular membrane-bounded organelle#GO:0043231;spliceosomal complex#GO:0005681;spliceosomal snRNP complex#GO:0097525;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ribonucleoprotein complex#GO:1990904;precatalytic spliceosome#GO:0071011;spliceosomal tri-snRNP complex#GO:0097526;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;small nuclear ribonucleoprotein complex#GO:0030532;nucleus#GO:0005634;Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513 RNA splicing factor#PC00148;RNA processing factor#PC00147 HUMAN|HGNC=16499|UniProtKB=Q96DA2 Q96DA2 RAB39B PTHR47979:SF69 DRAB11-RELATED RAS-RELATED PROTEIN RAB-39B pyrophosphatase activity#GO:0016462;myosin binding#GO:0017022;catalytic activity#GO:0003824;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;ion binding#GO:0043167;GTPase activity#GO:0003924;anion binding#GO:0043168;small molecule binding#GO:0036094;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;cytoskeletal protein binding#GO:0008092;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;guanyl nucleotide binding#GO:0019001;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;protein binding#GO:0005515 vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810;cellular process#GO:0009987 small GTPase#PC00208;G-protein#PC00020 HUMAN|HGNC=16814|UniProtKB=Q96NX9 Q96NX9 DACH2 PTHR12577:SF7 DACHSHUND DACHSHUND HOMOLOG 2 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;winged helix/forkhead transcription factor#PC00246 HUMAN|HGNC=4648|UniProtKB=Q00403 Q00403 GTF2B PTHR11618:SF77 TRANSCRIPTION INITIATION FACTOR IIB-RELATED TRANSCRIPTION INITIATION FACTOR IIB sequence-specific DNA binding#GO:0043565;transferase activity#GO:0016740;transcription regulatory region nucleic acid binding#GO:0001067;protein binding#GO:0005515;acetyltransferase activity#GO:0016407;binding#GO:0005488;sequence-specific double-stranded DNA binding#GO:1990837;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transcription factor binding#GO:0008134;catalytic activity#GO:0003824;DNA binding#GO:0003677;core promoter sequence-specific DNA binding#GO:0001046;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;acyltransferase activity#GO:0016746;transcription cis-regulatory region binding#GO:0000976 nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;protein-containing complex assembly#GO:0065003;DNA-templated transcription initiation#GO:0006352;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;RNA polymerase II preinitiation complex assembly#GO:0051123;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;transcription by RNA polymerase II#GO:0006366;cellular component organization or biogenesis#GO:0071840;protein-DNA complex organization#GO:0071824;macromolecule metabolic process#GO:0043170;protein-containing complex organization#GO:0043933;transcription initiation at RNA polymerase II promoter#GO:0006367;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component assembly#GO:0022607;gene expression#GO:0010467;protein-DNA complex assembly#GO:0065004;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-DNA complex#GO:0032993;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 general transcription factor#PC00259 General transcription regulation#P00023>TFIIB#P00668;Transcription regulation by bZIP transcription factor#P00055>TFIIB#P01397 HUMAN|HGNC=14007|UniProtKB=Q9H1Y3 Q9H1Y3 OPN3 PTHR24240:SF197 OPSIN OPSIN-3 molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;response to abiotic stimulus#GO:0009628;signaling#GO:0023052;cellular response to radiation#GO:0071478;cellular response to environmental stimulus#GO:0104004;regulation of cellular process#GO:0050794;response to light stimulus#GO:0009416;response to stimulus#GO:0050896;response to external stimulus#GO:0009605;cellular response to abiotic stimulus#GO:0071214;cellular response to light stimulus#GO:0071482;response to radiation#GO:0009314;cellular process#GO:0009987;signal transduction#GO:0007165;detection of stimulus#GO:0051606;biological regulation#GO:0065007 cilium#GO:0005929;membrane-bounded organelle#GO:0043227;non-motile cilium#GO:0097730;9+0 non-motile cilium#GO:0097731;membrane#GO:0016020;neuron projection#GO:0043005;photoreceptor cell cilium#GO:0097733;cell periphery#GO:0071944;photoreceptor outer segment#GO:0001750;organelle#GO:0043226;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025 G-protein coupled receptor#PC00021 HUMAN|HGNC=14895|UniProtKB=Q9BZM4 Q9BZM4 ULBP3 PTHR16675:SF199 MHC CLASS I-RELATED UL16-BINDING PROTEIN 3 signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;binding#GO:0005488;signaling receptor binding#GO:0005102;protein binding#GO:0005515;molecular function activator activity#GO:0140677 regulation of cell killing#GO:0031341;regulation of lymphocyte mediated immunity#GO:0002706;immune system process#GO:0002376;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449;regulation of biological process#GO:0050789;natural killer cell mediated immunity#GO:0002228;leukocyte mediated cytotoxicity#GO:0001909;biological process involved in interspecies interaction between organisms#GO:0044419;positive regulation of adaptive immune response#GO:0002821;response to stimulus#GO:0050896;immune effector process#GO:0002252;natural killer cell mediated cytotoxicity#GO:0042267;positive regulation of biological process#GO:0048518;defense response to symbiont#GO:0140546;cellular process#GO:0009987;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;positive regulation of immune system process#GO:0002684;defense response to other organism#GO:0098542;regulation of immune response#GO:0050776;regulation of leukocyte mediated cytotoxicity#GO:0001910;positive regulation of lymphocyte mediated immunity#GO:0002708;antigen processing and presentation#GO:0019882;regulation of immune effector process#GO:0002697;regulation of leukocyte mediated immunity#GO:0002703;response to external biotic stimulus#GO:0043207;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;positive regulation of leukocyte mediated immunity#GO:0002705;cell killing#GO:0001906;response to external stimulus#GO:0009605;defense response#GO:0006952;innate immune response#GO:0045087;immune response#GO:0006955;positive regulation of cellular process#GO:0048522;biological regulation#GO:0065007;positive regulation of immune effector process#GO:0002699;response to other organism#GO:0051707;positive regulation of response to stimulus#GO:0048584 side of membrane#GO:0098552;extracellular region#GO:0005576;external side of plasma membrane#GO:0009897;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 major histocompatibility complex protein#PC00149;defense/immunity protein#PC00090 HUMAN|HGNC=23506|UniProtKB=Q96SZ5 Q96SZ5 ADO PTHR22966:SF76 2-AMINOETHANETHIOL DIOXYGENASE 2-AMINOETHANETHIOL DIOXYGENASE catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;dioxygenase activity#GO:0051213;oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen#GO:0016702 cellular response to chemical stimulus#GO:0070887;cellular response to stress#GO:0033554;response to hypoxia#GO:0001666;response to abiotic stimulus#GO:0009628;response to stress#GO:0006950;cellular response to hypoxia#GO:0071456;response to decreased oxygen levels#GO:0036293;response to oxygen levels#GO:0070482;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to chemical#GO:0042221;response to stimulus#GO:0050896 mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=7059|UniProtKB=P16455 P16455 MGMT PTHR46460:SF1 METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE protein methyltransferase activity#GO:0008276;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741;methyltransferase activity#GO:0008168;catalytic activity, acting on a protein#GO:0140096 DNA damage response#GO:0006974;cellular response to stress#GO:0033554;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;primary metabolic process#GO:0044238;nucleobase-containing compound metabolic process#GO:0006139;response to stimulus#GO:0050896 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 HUMAN|HGNC=12697|UniProtKB=Q6UXI7 Q6UXI7 VIT PTHR24020:SF23 COLLAGEN ALPHA VITRIN extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;positive regulation of cell adhesion#GO:0045785;cellular process#GO:0009987;positive regulation of cell-substrate adhesion#GO:0010811;regulation of biological process#GO:0050789;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular component organization#GO:0016043;biological regulation#GO:0065007;regulation of cell-substrate adhesion#GO:0010810;regulation of cell adhesion#GO:0030155;regulation of cellular process#GO:0050794 extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;interstitial matrix#GO:0005614;cellular anatomical structure#GO:0110165 extracellular matrix structural protein#PC00103 HUMAN|HGNC=1382|UniProtKB=P35219 P35219 CA8 PTHR18952:SF104 CARBONIC ANHYDRASE CARBONIC ANHYDRASE-RELATED PROTEIN positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of cell communication#GO:0010646;regulation of calcium-mediated signaling#GO:0050848;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789;positive regulation of signaling#GO:0023056;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;positive regulation of calcium-mediated signaling#GO:0050850 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 dehydratase#PC00091;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=12545|UniProtKB=O75310 O75310 UGT2B11 PTHR48043:SF86 EG:EG0003.4 PROTEIN-RELATED UDP-GLUCURONOSYLTRANSFERASE 2B10-RELATED transferase activity#GO:0016740;catalytic activity#GO:0003824;glucuronosyltransferase activity#GO:0015020;hexosyltransferase activity#GO:0016758;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757 lipid metabolic process#GO:0006629;metabolic process#GO:0008152;regulation of biological quality#GO:0065008;estrogen metabolic process#GO:0008210;regulation of hormone levels#GO:0010817;cellular process#GO:0009987;primary metabolic process#GO:0044238;biological regulation#GO:0065007;steroid metabolic process#GO:0008202;hormone metabolic process#GO:0042445 HUMAN|HGNC=7391|UniProtKB=P28360 P28360 MSX1 PTHR24338:SF8 HOMEOBOX PROTEIN MSX HOMEOBOX PROTEIN MSX-1 transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;regulation of RNA metabolic process#GO:0051252;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;embryo development#GO:0009790;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;multicellular organism development#GO:0007275;embryonic morphogenesis#GO:0048598;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=20231|UniProtKB=Q9Y2U9 Q9Y2U9 KLHDC2 PTHR46228:SF3 KELCH DOMAIN-CONTAINING PROTEIN KELCH DOMAIN-CONTAINING PROTEIN 2 HUMAN|HGNC=16851|UniProtKB=Q5JS13 Q5JS13 RALGPS1 PTHR23113:SF167 GUANINE NUCLEOTIDE EXCHANGE FACTOR RAS-SPECIFIC GUANINE NUCLEOTIDE-RELEASING FACTOR RALGPS1 guanyl-nucleotide exchange factor activity#GO:0005085;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 intracellular signaling cassette#GO:0141124;regulation of signal transduction#GO:0009966;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of small GTPase mediated signal transduction#GO:0051056;regulation of response to stimulus#GO:0048583;regulation of cell communication#GO:0010646;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;Ras protein signal transduction#GO:0007265 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=30235|UniProtKB=Q9UHF3 Q9UHF3 NAT8B PTHR13947:SF48 GNAT FAMILY N-ACETYLTRANSFERASE N-ACETYLTRANSFERASE 8-RELATED N-acetyltransferase activity#GO:0008080;transferase activity#GO:0016740;catalytic activity#GO:0003824;acetyltransferase activity#GO:0016407;acyltransferase activity#GO:0016746;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 acetyltransferase#PC00038 HUMAN|HGNC=18782|UniProtKB=Q16204 Q16204 CCDC6 PTHR15276:SF0 H4 D10S170 PROTEIN-RELATED COILED-COIL DOMAIN-CONTAINING PROTEIN 6 HUMAN|HGNC=34454|UniProtKB=A6NI56 A6NI56 CCDC154 PTHR35153:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 154 COILED-COIL DOMAIN-CONTAINING PROTEIN 154 bone development#GO:0060348;anatomical structure maturation#GO:0071695;multicellular organismal process#GO:0032501;ossification#GO:0001503;tissue development#GO:0009888;developmental maturation#GO:0021700;developmental process#GO:0032502;biomineral tissue development#GO:0031214;bone mineralization#GO:0030282;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;animal organ development#GO:0048513;anatomical structure development#GO:0048856;skeletal system development#GO:0001501;multicellular organism development#GO:0007275 HUMAN|HGNC=6935|UniProtKB=P23508 P23508 MCC PTHR23347:SF4 COLORECTAL MUTANT CANCER PROTEIN MCC PROTEIN -RELATED COLORECTAL MUTANT CANCER PROTEIN regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;regulation of canonical Wnt signaling pathway#GO:0060828;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;negative regulation of Wnt signaling pathway#GO:0030178;negative regulation of response to stimulus#GO:0048585;regulation of signaling#GO:0023051;negative regulation of canonical Wnt signaling pathway#GO:0090090;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of Wnt signaling pathway#GO:0030111;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=14580|UniProtKB=O15085 O15085 ARHGEF11 PTHR45872:SF1 RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 11 molecular function regulator activity#GO:0098772;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;G protein-coupled receptor binding#GO:0001664;enzyme regulator activity#GO:0030234;protein binding#GO:0005515;signaling receptor binding#GO:0005102;guanyl-nucleotide exchange factor activity#GO:0005085;binding#GO:0005488 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=13634|UniProtKB=Q969L2 Q969L2 MAL2 PTHR22776:SF42 MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN PROTEIN MAL2 signaling#GO:0023052;biological regulation#GO:0065007;regulation of biological process#GO:0050789 membrane microdomain#GO:0098857;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;membrane raft#GO:0045121;membrane#GO:0016020;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 scaffold/adaptor protein#PC00226 HUMAN|HGNC=12471|UniProtKB=P41226 P41226 UBA7 PTHR10953:SF143 UBIQUITIN-ACTIVATING ENZYME E1 UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 7 ligase activity, forming carbon-sulfur bonds#GO:0016877;ATP-dependent activity#GO:0140657;sulfurtransferase activity#GO:0016783;thiosulfate-cyanide sulfurtransferase activity#GO:0004792;transferase activity, transferring sulphur-containing groups#GO:0016782;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;transferase activity, transferring phosphorus-containing groups#GO:0016772;ubiquitin-like modifier activating enzyme activity#GO:0008641;ligase activity#GO:0016874;catalytic activity, acting on a protein#GO:0140096 modification-dependent protein catabolic process#GO:0019941;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;protein modification process#GO:0036211;response to external biotic stimulus#GO:0043207;ISG15-protein conjugation#GO:0032020;catabolic process#GO:0009056;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;immune response#GO:0006955;response to other organism#GO:0051707;post-translational protein modification#GO:0043687;DNA damage response#GO:0006974;response to external stimulus#GO:0009605;ubiquitin-dependent protein catabolic process#GO:0006511;defense response#GO:0006952;macromolecule metabolic process#GO:0043170;innate immune response#GO:0045087;protein modification by small protein conjugation#GO:0032446;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;modification-dependent macromolecule catabolic process#GO:0043632;protein modification by small protein conjugation or removal#GO:0070647;immune system process#GO:0002376;defense response to symbiont#GO:0140546;cellular process#GO:0009987;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;protein ubiquitination#GO:0016567;defense response to other organism#GO:0098542;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 Ubiquitin proteasome pathway#P00060>E1#P01492;Ubiquitin proteasome pathway#P00060>E3#P01490 HUMAN|HGNC=33527|UniProtKB=F8WCM5 F8WCM5 INS-IGF2 PTHR11454:SF32 INSULIN/INSULIN GROWTH FACTOR INSULIN, ISOFORM 2 signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515;hormone activity#GO:0005179;molecular function activator activity#GO:0140677;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 growth factor#PC00112 HUMAN|HGNC=11359|UniProtKB=P49675 P49675 STAR PTHR46489:SF1 STEROIDOGENIC ACUTE REGULATORY PROTEIN, MITOCHONDRIAL STEROIDOGENIC ACUTE REGULATORY PROTEIN, MITOCHONDRIAL HUMAN|HGNC=26281|UniProtKB=Q6ZN84 Q6ZN84 CCDC81 PTHR14362:SF2 COILED-COIL DOMAIN-CONTAINING PROTEIN 81 COILED-COIL DOMAIN-CONTAINING PROTEIN 81 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microtubule cytoskeleton#GO:0015630 HUMAN|HGNC=29272|UniProtKB=Q8NCU4 Q8NCU4 CCDC191 PTHR22028:SF5 SFI1 SPINDLE BODY DOMAIN-CONTAINING PROTEIN-RELATED COILED-COIL DOMAIN-CONTAINING PROTEIN 191 binding#GO:0005488;phosphatase binding#GO:0019902;enzyme binding#GO:0019899;protein binding#GO:0005515 HUMAN|HGNC=10994|UniProtKB=P50443 P50443 SLC26A2 PTHR11814:SF16 SULFATE TRANSPORTER SULFATE TRANSPORTER active transmembrane transporter activity#GO:0022804;monoatomic ion transmembrane transporter activity#GO:0015075;dicarboxylic acid transmembrane transporter activity#GO:0005310;secondary active transmembrane transporter activity#GO:0015291;monoatomic anion transmembrane transporter activity#GO:0008509;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;antiporter activity#GO:0015297;bicarbonate transmembrane transporter activity#GO:0015106;chloride transmembrane transporter activity#GO:0015108;carboxylic acid transmembrane transporter activity#GO:0046943 monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;chloride transmembrane transport#GO:1902476;localization#GO:0051179;transport#GO:0006810;chloride transport#GO:0006821;monoatomic ion transmembrane transport#GO:0034220;monoatomic anion transmembrane transport#GO:0098656;cellular process#GO:0009987;monoatomic anion transport#GO:0006820 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227 HUMAN|HGNC=8087|UniProtKB=P29728 P29728 OAS2 PTHR11258:SF3 2-5 OLIGOADENYLATE SYNTHETASE 2'-5'-OLIGOADENYLATE SYNTHASE 2 transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;transferase activity, transferring phosphorus-containing groups#GO:0016772;RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;adenylyltransferase activity#GO:0070566;double-stranded RNA binding#GO:0003725 cell surface receptor signaling pathway#GO:0007166;response to cytokine#GO:0034097;response to chemical#GO:0042221;defense response to other organism#GO:0098542;defense response to symbiont#GO:0140546;signal transduction#GO:0007165;cellular process#GO:0009987;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;response to peptide#GO:1901652;immune system process#GO:0002376;type I interferon-mediated signaling pathway#GO:0060337;biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052;response to stimulus#GO:0050896;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;defense response to virus#GO:0051607;negative regulation of biological process#GO:0048519;response to external stimulus#GO:0009605;defense response#GO:0006952;innate immune response#GO:0045087;biological regulation#GO:0065007;response to other organism#GO:0051707;immune response#GO:0006955;cell communication#GO:0007154;response to virus#GO:0009615;cytokine-mediated signaling pathway#GO:0019221;response to external biotic stimulus#GO:0043207;regulation of cellular process#GO:0050794;antiviral innate immune response#GO:0140374;cellular response to stimulus#GO:0051716 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleus#GO:0005634;cytosol#GO:0005829;membrane-enclosed lumen#GO:0031974;membrane#GO:0016020;organelle lumen#GO:0043233 metabolite interconversion enzyme#PC00262;nucleotidyltransferase#PC00174 HUMAN|HGNC=15339|UniProtKB=Q8NGE7 Q8NGE7 OR9K2 PTHR26452:SF318 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 9K2 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 sensory perception of chemical stimulus#GO:0007606;nervous system process#GO:0050877;sensory perception#GO:0007600;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;system process#GO:0003008 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=25387|UniProtKB=Q8IYT4 Q8IYT4 KATNAL2 PTHR23074:SF78 AAA DOMAIN-CONTAINING KATANIN P60 ATPASE-CONTAINING SUBUNIT A-LIKE 2 hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP-dependent activity#GO:0140657;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817 spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226;microtubule-based process#GO:0007017;meiotic cell cycle#GO:0051321;sexual reproduction#GO:0019953;cytoskeleton organization#GO:0007010;reproductive process#GO:0022414;organelle organization#GO:0006996;cell cycle#GO:0007049;cellular component organization#GO:0016043;meiotic cell cycle process#GO:1903046;cellular process#GO:0009987;cell cycle process#GO:0022402 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;spindle#GO:0005819;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630 microtubule or microtubule-binding cytoskeletal protein#PC00157;non-motor microtubule binding protein#PC00166 HUMAN|HGNC=10603|UniProtKB=O75880 O75880 SCO1 PTHR12151:SF4 ELECTRON TRANSPORT PROTIN SCO1/SENC FAMILY MEMBER CYTOCHROME C OXIDASE ASSEMBLY FACTOR SCO1 organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;cellular component assembly#GO:0022607;mitochondrion organization#GO:0007005;mitochondrial respiratory chain complex assembly#GO:0033108;mitochondrial respiratory chain complex IV assembly#GO:0033617;cytochrome complex assembly#GO:0017004;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;respiratory chain complex IV assembly#GO:0008535 oxidase#PC00175;metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HUMAN|HGNC=6139|UniProtKB=P26006 P26006 ITGA3 PTHR23220:SF89 INTEGRIN ALPHA INTEGRIN ALPHA-3 cell adhesion molecule#PC00069;integrin#PC00126 Integrin signalling pathway#P00034>Integrin alpha#P00941 HUMAN|HGNC=3539|UniProtKB=O00254 O00254 F2RL2 PTHR24232:SF0 G-PROTEIN COUPLED RECEPTOR PROTEINASE-ACTIVATED RECEPTOR 3 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 Blood coagulation#P00011>mPAR-3#P00452 HUMAN|HGNC=11998|UniProtKB=P04637 P04637 TP53 PTHR11447:SF6 CELLULAR TUMOR ANTIGEN P53 CELLULAR TUMOR ANTIGEN P53 cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;chromatin binding#GO:0003682;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of gene expression#GO:0010468;apoptotic signaling pathway#GO:0097190;regulation of biosynthetic process#GO:0009889;DNA damage response#GO:0006974;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;intracellular signal transduction#GO:0035556;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;cell communication#GO:0007154;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;cell death#GO:0008219;cellular response to stimulus#GO:0051716;intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator#GO:0042771;programmed cell death#GO:0012501;regulation of apoptotic process#GO:0042981;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;response to stress#GO:0006950;intrinsic apoptotic signaling pathway in response to DNA damage#GO:0008630;intrinsic apoptotic signaling pathway#GO:0097193;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;cellular response to stress#GO:0033554;signal transduction by p53 class mediator#GO:0072331;signaling#GO:0023052;response to stimulus#GO:0050896;intrinsic apoptotic signaling pathway by p53 class mediator#GO:0072332;regulation of transcription by RNA polymerase II#GO:0006357;apoptotic process#GO:0006915;regulation of biological process#GO:0050789;regulation of programmed cell death#GO:0043067 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694;chromatin#GO:0000785;nucleus#GO:0005634 P53-like transcription factor#PC00253;gene-specific transcriptional regulator#PC00264 p53 pathway feedback loops 2#P04398>p53#P04668;Wnt signaling pathway#P00057>p53#P01430;Huntington disease#P00029>p53#P00797;p53 pathway#P00059>p53#P01485;p53 pathway by glucose deprivation#P04397>p53#P04640;P53 pathway feedback loops 1#P04392>p53#P04539;Apoptosis signaling pathway#P00006>p53#P00273;p53 pathway#P00059>p53#G04702 HUMAN|HGNC=18939|UniProtKB=Q3LI73 Q3LI73 KRTAP19-4 PTHR38140:SF5 KERATIN-ASSOCIATED PROTEIN 19-3-RELATED KERATIN-ASSOCIATED PROTEIN 19-4-RELATED structural protein#PC00211 HUMAN|HGNC=1502|UniProtKB=P31944 P31944 CASP14 PTHR10454:SF131 CASPASE CASPASE-14 cysteine-type endopeptidase activity#GO:0004197;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234 regulation of programmed cell death#GO:0043067;programmed cell death#GO:0012501;regulation of biological process#GO:0050789;apoptotic process#GO:0006915;cell death#GO:0008219;positive regulation of programmed cell death#GO:0043068;regulation of cellular process#GO:0050794;animal gross anatomical part developmental process#GO:0160108;anatomical structure development#GO:0048856;regulation of neuron apoptotic process#GO:0043523;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;tissue development#GO:0009888;biological regulation#GO:0065007;positive regulation of neuron apoptotic process#GO:0043525;epidermis development#GO:0008544;developmental process#GO:0032502;regulation of apoptotic process#GO:0042981;positive regulation of apoptotic process#GO:0043065 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protease#PC00190;protein modifying enzyme#PC00260 HUMAN|HGNC=30215|UniProtKB=Q6ZN28 Q6ZN28 MACC1 PTHR15603:SF1 SH3 DOMAIN-CONTAINING PROTEIN METASTASIS-ASSOCIATED IN COLON CANCER PROTEIN 1 DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;DNA-binding transcription activator activity#GO:0001216 regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 scaffold/adaptor protein#PC00226 HUMAN|HGNC=19697|UniProtKB=Q8TDN1 Q8TDN1 KCNG4 PTHR11537:SF167 VOLTAGE-GATED POTASSIUM CHANNEL VOLTAGE-GATED POTASSIUM CHANNEL REGULATORY SUBUNIT KCNG4 molecular function regulator activity#GO:0098772;channel regulator activity#GO:0016247;ion channel regulator activity#GO:0099106;transporter regulator activity#GO:0141108;potassium channel regulator activity#GO:0015459 transport#GO:0006810;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;potassium ion transport#GO:0006813;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;action potential#GO:0001508;metal ion transport#GO:0030001 membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cation channel complex#GO:0034703;voltage-gated potassium channel complex#GO:0008076;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351 ion channel#PC00133;voltage-gated ion channel#PC00241 HUMAN|HGNC=24987|UniProtKB=Q9HBL8 Q9HBL8 NMRAL1 PTHR42748:SF16 NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER NMRA-LIKE FAMILY DOMAIN-CONTAINING PROTEIN 1 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=2408|UniProtKB=P11844 P11844 CRYGA PTHR11818:SF119 BETA/GAMMA CRYSTALLIN GAMMA-CRYSTALLIN A structural molecule activity#GO:0005198 camera-type eye development#GO:0043010;animal gross anatomical part developmental process#GO:0160108;sensory perception#GO:0007600;nervous system process#GO:0050877;anatomical structure development#GO:0048856;system development#GO:0048731;eye development#GO:0001654;sensory perception of light stimulus#GO:0050953;visual perception#GO:0007601;visual system development#GO:0150063;sensory organ development#GO:0007423;lens development in camera-type eye#GO:0002088;developmental process#GO:0032502;multicellular organism development#GO:0007275;animal organ development#GO:0048513;system process#GO:0003008;sensory system development#GO:0048880;multicellular organismal process#GO:0032501 structural protein#PC00211 HUMAN|HGNC=14957|UniProtKB=Q14671 Q14671 PUM1 PTHR12537:SF1 RNA BINDING PROTEIN PUMILIO-RELATED PUMILIO HOMOLOG 1 RNA binding#GO:0003723;mRNA 3'-UTR binding#GO:0003730;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729 nucleic acid biosynthetic process#GO:0141187;miRNA processing#GO:0035196;regulation of biological quality#GO:0065008;RNA metabolic process#GO:0016070;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;negative regulation of gene expression#GO:0010629;negative regulation of metabolic process#GO:0009892;regulation of mRNA stability#GO:0043488;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;regulation of mRNA metabolic process#GO:1903311;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;RNA processing#GO:0006396;gene expression#GO:0010467;regulation of RNA stability#GO:0043487;regulation of RNA metabolic process#GO:0051252;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulatory ncRNA-mediated gene silencing#GO:0031047;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;regulatory ncRNA processing#GO:0070918;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;macromolecule biosynthetic process#GO:0009059;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 RNA metabolism protein#PC00031 HUMAN|HGNC=30034|UniProtKB=Q6ZUJ8 Q6ZUJ8 PIK3AP1 PTHR16267:SF12 BANK1/PIK3AP1 FAMILY MEMBER PHOSPHOINOSITIDE 3-KINASE ADAPTER PROTEIN 1 protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102;phosphatidylinositol 3-kinase binding#GO:0043548 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=5033|UniProtKB=P22626 P22626 HNRNPA2B1 PTHR48026:SF13 HOMOLOGOUS TO DROSOPHILA SQD (SQUID) PROTEIN HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEINS A2_B1 mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;single-stranded DNA binding#GO:0003697;RNA binding#GO:0003723;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;mRNA 3'-UTR binding#GO:0003730;telomeric repeat DNA binding#GO:0042162 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;nucleobase-containing compound transport#GO:0015931;RNA transport#GO:0050658;RNA localization#GO:0006403;RNA biosynthetic process#GO:0032774;establishment of RNA localization#GO:0051236;mRNA transport#GO:0051028;mRNA metabolic process#GO:0016071;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;localization#GO:0051179;nucleic acid transport#GO:0050657;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;mRNA processing#GO:0006397;macromolecule localization#GO:0033036;nitrogen compound transport#GO:0071705;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;transport#GO:0006810;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170;establishment of localization#GO:0051234 nuclear protein-containing complex#GO:0140513;catalytic step 2 spliceosome#GO:0071013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;spliceosomal complex#GO:0005681;nucleus#GO:0005634 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HUMAN|HGNC=3357|UniProtKB=Q13822 Q13822 ENPP2 PTHR10151:SF21 ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE AUTOTAXIN lipase activity#GO:0016298;small molecule binding#GO:0036094;phosphatidylcholine lysophospholipase A1 activity#GO:0004622;ion binding#GO:0043167;carboxylic ester hydrolase activity#GO:0052689;transition metal ion binding#GO:0046914;hydrolase activity#GO:0016787;cation binding#GO:0043169;catalytic activity#GO:0003824;zinc ion binding#GO:0008270;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity, acting on ester bonds#GO:0016788;binding#GO:0005488;exonuclease activity#GO:0004527;metal ion binding#GO:0046872;nuclease activity#GO:0004518;glycerophospholipase activity#GO:0004620;phospholipase activity#GO:0120569;phosphoric ester hydrolase activity#GO:0042578;phosphoric diester hydrolase activity#GO:0008081 glycerophospholipid catabolic process#GO:0046475;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;glycerophospholipid metabolic process#GO:0006650;phosphatidylcholine metabolic process#GO:0046470;organophosphate metabolic process#GO:0019637;lipid catabolic process#GO:0016042;cellular process#GO:0009987;organophosphate catabolic process#GO:0046434;glycerolipid catabolic process#GO:0046503;catabolic process#GO:0009056;glycerolipid metabolic process#GO:0046486;phospholipid catabolic process#GO:0009395;phospholipid metabolic process#GO:0006644;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 hydrolase#PC00121;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=23170|UniProtKB=O75717 O75717 WDHD1 PTHR19932:SF10 WD REPEAT AND HMG-BOX DNA BINDING PROTEIN WD REPEAT AND HMG-BOX DNA-BINDING PROTEIN 1 chromatin binding#GO:0003682;binding#GO:0005488 DNA-templated DNA replication#GO:0006261;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;mitotic cell cycle#GO:0000278;cellular response to stimulus#GO:0051716;DNA replication#GO:0006260;cell cycle#GO:0007049;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;response to stress#GO:0006950 membraneless organelle#GO:0043228;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nuclear replication fork#GO:0043596;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;replication fork#GO:0005657;chromosome#GO:0005694;organelle lumen#GO:0043233 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=32038|UniProtKB=Q5VUY2 Q5VUY2 AADACL4 PTHR23024:SF603 ARYLACETAMIDE DEACETYLASE ARYLACETAMIDE DEACETYLASE-LIKE 4 cellular anatomical structure#GO:0110165;membrane#GO:0016020 deacetylase#PC00087 HUMAN|HGNC=4922|UniProtKB=P19367 P19367 HK1 PTHR19443:SF10 HEXOKINASE HEXOKINASE-1 phosphotransferase activity, alcohol group as acceptor#GO:0016773;hexokinase activity#GO:0004396;catalytic activity#GO:0003824;transferase activity#GO:0016740;carbohydrate kinase activity#GO:0019200;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 ribonucleotide metabolic process#GO:0009259;purine nucleoside diphosphate metabolic process#GO:0009135;nucleotide metabolic process#GO:0009117;carbohydrate catabolic process#GO:0016052;monocarboxylic acid metabolic process#GO:0032787;purine nucleotide metabolic process#GO:0006163;pyridine-containing compound catabolic process#GO:0072526;purine-containing compound metabolic process#GO:0072521;pyruvate metabolic process#GO:0006090;ADP catabolic process#GO:0046032;nucleobase-containing small molecule metabolic process#GO:0055086;glucose homeostasis#GO:0042593;purine nucleoside diphosphate catabolic process#GO:0009137;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;nucleoside diphosphate metabolic process#GO:0009132;pyridine-containing compound metabolic process#GO:0072524;purine ribonucleoside diphosphate catabolic process#GO:0009181;aerobic respiration#GO:0009060;primary metabolic process#GO:0044238;hexose metabolic process#GO:0019318;purine nucleoside triphosphate metabolic process#GO:0009144;nucleoside phosphate catabolic process#GO:1901292;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate derivative catabolic process#GO:1901136;generation of precursor metabolites and energy#GO:0006091;purine ribonucleoside diphosphate metabolic process#GO:0009179;ADP metabolic process#GO:0046031;cellular homeostasis#GO:0019725;organophosphate metabolic process#GO:0019637;glycolytic process#GO:0006096;purine ribonucleoside triphosphate metabolic process#GO:0009205;oxoacid metabolic process#GO:0043436;intracellular glucose homeostasis#GO:0001678;phosphorus metabolic process#GO:0006793;carboxylic acid metabolic process#GO:0019752;carbohydrate homeostasis#GO:0033500;ribonucleoside diphosphate metabolic process#GO:0009185;small molecule metabolic process#GO:0044281;pyridine nucleotide catabolic process#GO:0019364;metabolic process#GO:0008152;monosaccharide metabolic process#GO:0005996;purine ribonucleotide metabolic process#GO:0009150;chemical homeostasis#GO:0048878;purine-containing compound catabolic process#GO:0072523;glucose metabolic process#GO:0006006;nicotinamide nucleotide metabolic process#GO:0046496;ATP metabolic process#GO:0046034;purine nucleotide catabolic process#GO:0006195;ribonucleoside diphosphate catabolic process#GO:0009191;organophosphate catabolic process#GO:0046434;cellular respiration#GO:0045333;purine ribonucleotide catabolic process#GO:0009154;nucleoside diphosphate catabolic process#GO:0009134;glucose 6-phosphate metabolic process#GO:0051156;catabolic process#GO:0009056;carbohydrate metabolic process#GO:0005975;homeostatic process#GO:0042592;nucleoside phosphate metabolic process#GO:0006753;nucleotide catabolic process#GO:0009166;energy derivation by oxidation of organic compounds#GO:0015980;intracellular chemical homeostasis#GO:0055082;nucleobase-containing compound catabolic process#GO:0034655;ribonucleotide catabolic process#GO:0009261;carbohydrate derivative metabolic process#GO:1901135;nucleobase-containing compound metabolic process#GO:0006139 cytoplasm#GO:0005737;organelle outer membrane#GO:0031968;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;membrane#GO:0016020;cytosol#GO:0005829;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;mitochondrial outer membrane#GO:0005741;cytoplasmic side of membrane#GO:0098562;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;organelle envelope#GO:0031967;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;side of membrane#GO:0098552;outer membrane#GO:0019867;intracellular organelle#GO:0043229 kinase#PC00137;metabolite interconversion enzyme#PC00262;transferase#PC00220 Glycolysis#P00024>Hexokinase#P00677;Pentose phosphate pathway#P02762>Hexokinase#P03079;Fructose galactose metabolism#P02744>Hexokinase#P02966 HUMAN|HGNC=31367|UniProtKB=Q5T6J7 Q5T6J7 IDNK PTHR43442:SF3 GLUCONOKINASE-RELATED GLUCONOKINASE transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773 purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;phosphorus metabolic process#GO:0006793;monocarboxylic acid metabolic process#GO:0032787;nucleoside phosphate metabolic process#GO:0006753;carbohydrate metabolic process#GO:0005975;glucose 6-phosphate metabolic process#GO:0051156;small molecule metabolic process#GO:0044281;NADPH regeneration#GO:0006740;pyridine-containing compound metabolic process#GO:0072524;pentose-phosphate shunt#GO:0006098;oxoacid metabolic process#GO:0043436;nucleotide metabolic process#GO:0009117;cellular process#GO:0009987;nicotinamide nucleotide metabolic process#GO:0046496;carbohydrate derivative metabolic process#GO:1901135;NADP+ metabolic process#GO:0006739;organophosphate metabolic process#GO:0019637;nucleobase-containing compound metabolic process#GO:0006139;generation of precursor metabolites and energy#GO:0006091;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086 kinase#PC00137 HUMAN|HGNC=18537|UniProtKB=Q9NV92 Q9NV92 NDFIP2 PTHR13396:SF4 NEDD4 FAMILY INTERACTING PROTEIN 1/2 NEDD4 FAMILY-INTERACTING PROTEIN 2 biological regulation#GO:0065007;positive regulation of protein ubiquitination#GO:0031398;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;regulation of primary metabolic process#GO:0080090;ubiquitin-dependent protein catabolic process#GO:0006511;regulation of protein modification process#GO:0031399;macromolecule metabolic process#GO:0043170;regulation of protein ubiquitination#GO:0031396;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;regulation of protein modification by small protein conjugation or removal#GO:1903320;protein metabolic process#GO:0019538;positive regulation of metabolic process#GO:0009893;regulation of post-translational protein modification#GO:1901873;modification-dependent macromolecule catabolic process#GO:0043632;positive regulation of protein metabolic process#GO:0051247;protein catabolic process#GO:0030163 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;perinuclear region of cytoplasm#GO:0048471;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 HUMAN|HGNC=26823|UniProtKB=Q6P6B1 Q6P6B1 ERICH5 PTHR23006:SF0 GLUTAMATE-RICH PROTEIN 5 GLUTAMATE-RICH PROTEIN 5 HUMAN|HGNC=15698|UniProtKB=Q7Z7E8 Q7Z7E8 UBE2Q1 PTHR24068:SF56 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2 Q1 acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-like protein conjugating enzyme activity#GO:0061650;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;ubiquitin conjugating enzyme activity#GO:0061631;aminoacyltransferase activity#GO:0016755 protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;primary metabolic process#GO:0044238;protein modification process#GO:0036211;cellular process#GO:0009987;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=30776|UniProtKB=Q8N3X6 Q8N3X6 LCORL PTHR21545:SF10 TRANSCRIPTION FACTOR MLR1/2 LIGAND-DEPENDENT NUCLEAR RECEPTOR COREPRESSOR-LIKE PROTEIN regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 DNA-binding transcription factor#PC00218 HUMAN|HGNC=4683|UniProtKB=Q16661 Q16661 GUCA2B PTHR11318:SF4 GUANYLIN FAMILY MEMBER GUANYLATE CYCLASE ACTIVATOR 2B cyclase regulator activity#GO:0010851;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234 protein-binding activity modulator#PC00095 HUMAN|HGNC=15770|UniProtKB=Q12836 Q12836 ZP4 PTHR23343:SF31 ZONA PELLUCIDA SPERM-BINDING PROTEIN ZONA PELLUCIDA SPERM-BINDING PROTEIN 4 binding#GO:0005488;enzyme binding#GO:0019899;extracellular matrix structural constituent#GO:0005201;protein binding#GO:0005515;structural molecule activity#GO:0005198 single fertilization#GO:0007338;negative regulation of biological process#GO:0048519;cellular process#GO:0009987;regulation of biological process#GO:0050789;multicellular organismal process#GO:0032501;regulation of reproductive process#GO:2000241;reproductive process#GO:0022414;fertilization#GO:0009566;biological regulation#GO:0065007;sperm-egg recognition#GO:0035036;cell activation#GO:0001775;cell recognition#GO:0008037;sexual reproduction#GO:0019953;binding of sperm to zona pellucida#GO:0007339;cell-cell recognition#GO:0009988 extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical structure#GO:0110165 HUMAN|HGNC=9197|UniProtKB=P52435 P52435 POLR2J PTHR13946:SF47 DNA-DIRECTED RNA POLYMERASE I,II,III DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11-A catalytic activity, acting on RNA#GO:0140098;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a nucleic acid#GO:0140640;nucleotidyltransferase activity#GO:0016779 nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654 nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;protein-containing complex#GO:0032991;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;RNA polymerase II, holoenzyme#GO:0016591;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;membrane-bounded organelle#GO:0043227;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;RNA polymerase II, core complex#GO:0005665;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 HUMAN|HGNC=15005|UniProtKB=Q8N628 Q8N628 OR2C3 PTHR26453:SF117 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2C3 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;nervous system process#GO:0050877;sensory perception#GO:0007600;system process#GO:0003008;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;detection of chemical stimulus#GO:0009593;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;response to chemical#GO:0042221;response to stimulus#GO:0050896 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=10928|UniProtKB=O60669 O60669 SLC16A7 PTHR11360:SF25 MONOCARBOXYLATE TRANSPORTER MONOCARBOXYLATE TRANSPORTER 2 monocarboxylic acid transmembrane transporter activity#GO:0008028;carboxylic acid transmembrane transporter activity#GO:0046943;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 organic hydroxy compound transport#GO:0015850;monocarboxylic acid transport#GO:0015718;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;carboxylic acid transport#GO:0046942;transport#GO:0006810;organic acid transport#GO:0015849;carboxylic acid transmembrane transport#GO:1905039;cellular process#GO:0009987 basal plasma membrane#GO:0009925;cell periphery#GO:0071944;basolateral plasma membrane#GO:0016323;basal part of cell#GO:0045178;membrane#GO:0016020;plasma membrane#GO:0005886;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165 transporter#PC00227 HUMAN|HGNC=17592|UniProtKB=Q9BT67 Q9BT67 NDFIP1 PTHR13396:SF3 NEDD4 FAMILY INTERACTING PROTEIN 1/2 NEDD4 FAMILY-INTERACTING PROTEIN 1 regulation of protein ubiquitination#GO:0031396;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;regulation of protein modification process#GO:0031399;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;positive regulation of protein ubiquitination#GO:0031398;positive regulation of macromolecule metabolic process#GO:0010604;modification-dependent macromolecule catabolic process#GO:0043632;positive regulation of protein metabolic process#GO:0051247;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;positive regulation of metabolic process#GO:0009893;regulation of post-translational protein modification#GO:1901873;modification-dependent protein catabolic process#GO:0019941;regulation of biological process#GO:0050789;primary metabolic process#GO:0044238;regulation of protein modification by small protein conjugation or removal#GO:1903320;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;perinuclear region of cytoplasm#GO:0048471;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794 HUMAN|HGNC=29218|UniProtKB=Q9ULL0 Q9ULL0 KIAA1210 PTHR47743:SF2 KIAA1210 / KIAA1211 FAMILY MEMBER ACROSOMAL PROTEIN KIAA1210 HUMAN|HGNC=3748|UniProtKB=P20930 P20930 FLG PTHR22571:SF51 FILAGGRIN-RELATED FILAGGRIN epithelium development#GO:0060429;tissue development#GO:0009888;skin development#GO:0043588;animal organ development#GO:0048513;anatomical structure development#GO:0048856;animal gross anatomical part developmental process#GO:0160108;epidermis development#GO:0008544;developmental process#GO:0032502 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085 HUMAN|HGNC=14866|UniProtKB=Q96QV1 Q96QV1 HHIP PTHR19328:SF27 HEDGEHOG-INTERACTING PROTEIN HEDGEHOG-INTERACTING PROTEIN protein-binding activity modulator#PC00095 HUMAN|HGNC=19847|UniProtKB=P0C221 P0C221 CCDC175 PTHR35347:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 175 COILED-COIL DOMAIN-CONTAINING PROTEIN 175 HUMAN|HGNC=28027|UniProtKB=O95876 O95876 WDPCP PTHR13667:SF5 HOMOLOC-13 WD REPEAT-CONTAINING AND PLANAR CELL POLARITY EFFECTOR PROTEIN FRITZ HOMOLOG HUMAN|HGNC=35154|UniProtKB=A6NCF6 A6NCF6 MAGEA13P PTHR11736:SF85 MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN MAGE DOMAIN-CONTAINING PROTEIN MAGEA13P-RELATED regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 scaffold/adaptor protein#PC00226 HUMAN|HGNC=9154|UniProtKB=Q96T60 Q96T60 PNKP PTHR12083:SF9 BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE phosphotransferase activity, alcohol group as acceptor#GO:0016773;hydrolase activity#GO:0016787;nucleobase-containing compound kinase activity#GO:0019205;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity, acting on ester bonds#GO:0016788;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphatase activity#GO:0016791;transferase activity#GO:0016740;catalytic activity#GO:0003824 cellular response to stress#GO:0033554;base-excision repair#GO:0006284;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;double-strand break repair via nonhomologous end joining#GO:0006303;double-strand break repair#GO:0006302;response to stress#GO:0006950;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 phosphatase#PC00181;metabolite interconversion enzyme#PC00262;nucleotide phosphatase#PC00173 HUMAN|HGNC=32263|UniProtKB=P0C7V4 P0C7V4 FAM90A15 PTHR16035:SF14 PROTEIN FAM90A1 PROTEIN FAM90A10-RELATED HUMAN|HGNC=28501|UniProtKB=Q96BV0 Q96BV0 ZNF775 PTHR24377:SF614 IP01015P-RELATED ZINC FINGER PROTEIN 775 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=26233|UniProtKB=Q5JST6 Q5JST6 EFHC2 PTHR12086:SF11 EF-HAND DOMAIN C-TERMINAL CONTAINING PROTEIN EF-HAND DOMAIN-CONTAINING FAMILY MEMBER C2 regulation of anatomical structure morphogenesis#GO:0022603;developmental growth#GO:0048589;regulation of plasma membrane bounded cell projection organization#GO:0120035;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;neuromuscular junction development#GO:0007528;regulation of cell projection organization#GO:0031344;growth#GO:0040007;developmental process#GO:0032502;multicellular organismal process#GO:0032501;cellular component assembly#GO:0022607;nervous system development#GO:0007399;biological regulation#GO:0065007;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;regulation of neuron projection development#GO:0010975;anatomical structure development#GO:0048856;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;synapse organization#GO:0050808;synapse assembly#GO:0007416;regulation of dendrite development#GO:0050773;cell junction organization#GO:0034330;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of developmental process#GO:0050793;cellular component organization#GO:0016043;regulation of dendrite morphogenesis#GO:0048814;cell junction assembly#GO:0034329;regulation of biological process#GO:0050789 cytoplasmic microtubule#GO:0005881;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;axonemal microtubule#GO:0005879;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;cilium#GO:0005929;membrane-bounded organelle#GO:0043227;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;axoneme#GO:0005930;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;ciliary plasm#GO:0097014;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513 calmodulin-related#PC00061;calcium-binding protein#PC00060 HUMAN|HGNC=26182|UniProtKB=Q8NBJ5 Q8NBJ5 COLGALT1 PTHR10730:SF28 PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER PROCOLLAGEN GALACTOSYLTRANSFERASE 1 galactosyltransferase activity#GO:0008378;catalytic activity, acting on a protein#GO:0140096;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;catalytic activity#GO:0003824 protein modifying enzyme#PC00260 HUMAN|HGNC=37166|UniProtKB=P0CJ76 P0CJ76 MTRNR2L9 PTHR33895:SF18 HUMANIN-LIKE 4 HUMANIN-LIKE 1-RELATED signaling receptor regulator activity#GO:0030545;signaling receptor inhibitor activity#GO:0030547;molecular function regulator activity#GO:0098772;molecular function inhibitor activity#GO:0140678 biological regulation#GO:0065007;regulation of cellular process#GO:0050794;negative regulation of apoptotic process#GO:0043066;regulation of biological process#GO:0050789;negative regulation of programmed cell death#GO:0043069;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;regulation of apoptotic process#GO:0042981;negative regulation of cellular process#GO:0048523 HUMAN|HGNC=30949|UniProtKB=Q96MM3 Q96MM3 ZFP42 PTHR14003:SF8 TRANSCRIPTIONAL REPRESSOR PROTEIN YY ZINC FINGER PROTEIN 42 HOMOLOG RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 developmental process#GO:0032502;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;cellular process#GO:0009987;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of biological process#GO:0050789;cell development#GO:0048468;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255 nucleus#GO:0005634;chromatin#GO:0000785;PcG protein complex#GO:0031519;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=34339|UniProtKB=Q3ZCQ3 Q3ZCQ3 FAM174B PTHR28607:SF3 EXPRESSED PROTEIN MEMBRANE PROTEIN FAM174B HUMAN|HGNC=9785|UniProtKB=P51148 P51148 RAB5C PTHR24073:SF366 DRAB5-RELATED RAS-RELATED PROTEIN RAB-5C ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824 endocytosis#GO:0006897;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular localization#GO:0051641;import into cell#GO:0098657;establishment of localization#GO:0051234;localization#GO:0051179;protein transport#GO:0015031;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;transport#GO:0006810;intracellular protein transport#GO:0006886 cell periphery#GO:0071944;membrane#GO:0016020;cytoplasm#GO:0005737;plasma membrane#GO:0005886;endomembrane system#GO:0012505;endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;early endosome#GO:0005769;endocytic vesicle#GO:0030139;membrane-bounded organelle#GO:0043227;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 small GTPase#PC00208;G-protein#PC00020 HUMAN|HGNC=28290|UniProtKB=Q5VUD6 Q5VUD6 DIPK1B PTHR21093:SF3 DIVERGENT PROTEIN KINASE DOMAIN 1C-RELATED DIVERGENT PROTEIN KINASE DOMAIN 1B HUMAN|HGNC=14412|UniProtKB=Q9BYV1 Q9BYV1 AGXT2 PTHR45688:SF3 FAMILY NOT NAMED ALANINE--GLYOXYLATE AMINOTRANSFERASE 2, MITOCHONDRIAL HUMAN|HGNC=11490|UniProtKB=Q9BX26 Q9BX26 SYCP2 PTHR15607:SF12 SYNAPTONEMAL COMPLEX PROTEIN-RELATED SYNAPTONEMAL COMPLEX PROTEIN 2 condensed nuclear chromosome#GO:0000794;synaptonemal complex#GO:0000795;membraneless organelle#GO:0043228;condensed chromosome#GO:0000793;chromosome, centromeric region#GO:0000775;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;synaptonemal structure#GO:0099086;condensed chromosome, centromeric region#GO:0000779;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;organelle lumen#GO:0043233 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=19658|UniProtKB=Q7RTS5 Q7RTS5 OTOP3 PTHR21522:SF36 PROTON CHANNEL OTOP PROTON CHANNEL OTOP3 binding#GO:0005488;protein binding#GO:0005515;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;passive transmembrane transporter activity#GO:0022803;proton transmembrane transporter activity#GO:0015078;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic cation channel activity#GO:0005261;identical protein binding#GO:0042802;proton channel activity#GO:0015252 establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;proton transmembrane transport#GO:1902600;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;transport#GO:0006810;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227 HUMAN|HGNC=22982|UniProtKB=Q92613 Q92613 JADE3 PTHR13793:SF27 PHD FINGER PROTEINS PROTEIN JADE-3 chromatin-protein adaptor activity#GO:0140463;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;histone reader activity#GO:0140566 chromatin remodeling#GO:0006338;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889 acetyltransferase complex#GO:1902493;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;protein acetyltransferase complex#GO:0031248;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;membraneless organelle#GO:0043228;histone acetyltransferase complex#GO:0000123;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;chromatin#GO:0000785;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;zinc finger transcription factor#PC00244 HUMAN|HGNC=18647|UniProtKB=Q8WWV3 Q8WWV3 RTN4IP1 PTHR11695:SF652 ALCOHOL DEHYDROGENASE RELATED NAD(P)H OXIDOREDUCTASE RTN4IP1, MITOCHONDRIAL catalytic activity#GO:0003824;NADH dehydrogenase activity#GO:0003954;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on NAD(P)H#GO:0016651;NAD(P)H dehydrogenase (quinone) activity#GO:0003955;oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor#GO:0016655 small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152;biosynthetic process#GO:0009058;small molecule metabolic process#GO:0044281;ubiquinone biosynthetic process#GO:0006744;cellular process#GO:0009987;ketone biosynthetic process#GO:0042181;ketone metabolic process#GO:0042180 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=25123|UniProtKB=Q504Y2 Q504Y2 PKDCC PTHR46448:SF3 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN EXTRACELLULAR TYROSINE-PROTEIN KINASE PKDCC HUMAN|HGNC=26850|UniProtKB=Q8N801 Q8N801 STPG4 PTHR35678:SF1 PROTEIN STPG4 PROTEIN STPG4 chromatin binding#GO:0003682;binding#GO:0005488 regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;cellular component organization#GO:0016043;epigenetic regulation of gene expression#GO:0040029;cellular process#GO:0009987;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;chromatin remodeling#GO:0006338;chromatin organization#GO:0006325;biological regulation#GO:0065007 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=19747|UniProtKB=Q86UK5 Q86UK5 EVC2 PTHR16795:SF14 LIMBIN/ELLIS-VAN CREVELD PROTEIN LIMBIN cell communication#GO:0007154;smoothened signaling pathway#GO:0007224;cell surface receptor signaling pathway#GO:0007166;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165 membrane#GO:0016020;cell periphery#GO:0071944;protein-containing complex#GO:0032991;plasma membrane region#GO:0098590;ciliary membrane#GO:0060170;plasma membrane#GO:0005886;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cilium#GO:0005929;cell projection membrane#GO:0031253;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=12014|UniProtKB=P51580 P51580 TPMT PTHR10259:SF11 THIOPURINE S-METHYLTRANSFERASE THIOPURINE S-METHYLTRANSFERASE catalytic activity#GO:0003824;transferase activity#GO:0016740;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;transferase activity, transferring one-carbon groups#GO:0016741 methyltransferase#PC00155;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=8867|UniProtKB=Q9UHV9 Q9UHV9 PFDN2 PTHR13303:SF0 PREFOLDIN SUBUNIT 2 PREFOLDIN SUBUNIT 2 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;protein maturation#GO:0051604;protein folding#GO:0006457;biosynthetic process#GO:0009058 protein-containing complex#GO:0032991 chaperone#PC00072 HUMAN|HGNC=17660|UniProtKB=Q6PJP8 Q6PJP8 DCLRE1A PTHR23240:SF6 DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED DNA CROSS-LINK REPAIR 1A PROTEIN DNA binding#GO:0003677;hydrolase activity#GO:0016787;5'-3' exonuclease activity#GO:0008409;DNA exonuclease activity, producing 5'-phosphomonoesters#GO:0016895;nuclease activity#GO:0004518;binding#GO:0005488;nucleic acid binding#GO:0003676;exonuclease activity#GO:0004527;catalytic activity, acting on DNA#GO:0140097;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity, acting on ester bonds#GO:0016788;DNA nuclease activity#GO:0004536;damaged DNA binding#GO:0003684;DNA exonuclease activity#GO:0004529 double-strand break repair via nonhomologous end joining#GO:0006303;macromolecule metabolic process#GO:0043170;double-strand break repair#GO:0006302;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA damage response#GO:0006974;interstrand cross-link repair#GO:0036297;nucleobase-containing compound metabolic process#GO:0006139;response to stress#GO:0006950;cellular process#GO:0009987;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular response to stimulus#GO:0051716 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA metabolism protein#PC00009 HUMAN|HGNC=20508|UniProtKB=Q8IUE6 Q8IUE6 H2AC21 PTHR23430:SF72 HISTONE H2A HISTONE H2A TYPE 2-B structural molecule activity#GO:0005198 negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;heterochromatin formation#GO:0031507;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;epigenetic regulation of gene expression#GO:0040029;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;cellular component assembly#GO:0022607;biological regulation#GO:0065007;chromatin organization#GO:0006325;negative regulation of biosynthetic process#GO:0009890;heterochromatin organization#GO:0070828;negative regulation of cellular process#GO:0048523;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;negative regulation of gene expression, epigenetic#GO:0045814;regulation of gene expression#GO:0010468 protein-DNA complex#GO:0032993;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;nucleosome#GO:0000786;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;nucleus#GO:0005634;chromatin#GO:0000785;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=4263|UniProtKB=P10912 P10912 GHR PTHR23036:SF108 CYTOKINE RECEPTOR GROWTH HORMONE RECEPTOR molecular transducer activity#GO:0060089;protein binding#GO:0005515;transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488;cytokine binding#GO:0019955;signaling receptor activity#GO:0038023;immune receptor activity#GO:0140375;cytokine receptor activity#GO:0004896 enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of cell population proliferation#GO:0042127;cell communication#GO:0007154;response to nitrogen compound#GO:1901698;positive regulation of receptor signaling pathway via JAK-STAT#GO:0046427;cytokine-mediated signaling pathway#GO:0019221;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of receptor signaling pathway via STAT#GO:1904892;cellular response to peptide hormone stimulus#GO:0071375;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;regulation of response to stimulus#GO:0048583;regulation of receptor signaling pathway via JAK-STAT#GO:0046425;cellular response to nitrogen compound#GO:1901699;positive regulation of response to stimulus#GO:0048584;response to peptide hormone#GO:0043434;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of cellular process#GO:0048522;positive regulation of signaling#GO:0023056;response to peptide#GO:1901652;cellular response to chemical stimulus#GO:0070887;regulation of signaling#GO:0023051;response to oxygen-containing compound#GO:1901700;cellular response to hormone stimulus#GO:0032870;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;signaling#GO:0023052;positive regulation of cell population proliferation#GO:0008284;response to endogenous stimulus#GO:0009719;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;cell surface receptor signaling pathway#GO:0007166;response to cytokine#GO:0034097;response to chemical#GO:0042221;response to hormone#GO:0009725;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular response to oxygen-containing compound#GO:1901701 cell periphery#GO:0071944;cytosol#GO:0005829;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;signaling receptor complex#GO:0043235;intracellular anatomical structure#GO:0005622 transmembrane signal receptor#PC00197 HUMAN|HGNC=27315|UniProtKB=Q0P670 Q0P670 SPEM2 PTHR34834:SF2 SPERMATID MATURATION PROTEIN 1 SPEM FAMILY MEMBER 2 HUMAN|HGNC=6413|UniProtKB=P13645 P13645 KRT10 PTHR23239:SF137 INTERMEDIATE FILAMENT KERATIN, TYPE I CYTOSKELETAL 10 structural molecule activity#GO:0005198 epidermis development#GO:0008544;developmental process#GO:0032502;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;animal organ development#GO:0048513;morphogenesis of an epithelium#GO:0002009;organelle organization#GO:0006996;cellular process#GO:0009987;epithelium development#GO:0060429;tissue development#GO:0009888;epidermal cell differentiation#GO:0009913;epithelial cell differentiation#GO:0030855;skin development#GO:0043588;cytoskeleton organization#GO:0007010;intermediate filament-based process#GO:0045103;animal gross anatomical part developmental process#GO:0160108;keratinocyte differentiation#GO:0030216;intermediate filament organization#GO:0045109;tissue morphogenesis#GO:0048729;anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cell differentiation#GO:0030154;intermediate filament cytoskeleton organization#GO:0045104 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;intermediate filament#GO:0005882;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;supramolecular complex#GO:0099080;organelle#GO:0043226 intermediate filament#PC00129 HUMAN|HGNC=14540|UniProtKB=Q9H4A3 Q9H4A3 WNK1 PTHR13902:SF46 SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED SERINE_THREONINE-PROTEIN KINASE WNK1 catalytic activity, acting on a protein#GO:0140096;molecular function regulator activity#GO:0098772;ion channel inhibitor activity#GO:0008200;ion channel regulator activity#GO:0099106;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773;molecular function inhibitor activity#GO:0140678;protein kinase activity#GO:0004672;channel regulator activity#GO:0016247;protein serine/threonine kinase activity#GO:0004674;potassium channel regulator activity#GO:0015459;transporter regulator activity#GO:0141108 regulation of localization#GO:0032879;regulation of transport#GO:0051049;regulation of monoatomic cation transmembrane transport#GO:1904062;chemical homeostasis#GO:0048878;regulation of monoatomic ion transport#GO:0043269;biological regulation#GO:0065007;monoatomic ion homeostasis#GO:0050801;positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165;positive regulation of transport#GO:0051050;positive regulation of biological process#GO:0048518;regulation of monoatomic ion transmembrane transport#GO:0034765;cellular process#GO:0009987;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of metal ion transport#GO:0010959;negative regulation of transport#GO:0051051;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;homeostatic process#GO:0042592;negative regulation of biological process#GO:0048519;regulation of transmembrane transport#GO:0034762;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=7007|UniProtKB=P61006 P61006 RAB8A PTHR47980:SF33 LD44762P RAS-RELATED PROTEIN RAB-8A plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;macromolecule localization#GO:0033036;intracellular protein localization#GO:0008104;vesicle-mediated transport to the plasma membrane#GO:0098876;establishment of localization#GO:0051234;transport#GO:0006810;regulation of postsynaptic membrane neurotransmitter receptor levels#GO:0099072;intracellular transport#GO:0046907;plasma membrane bounded cell projection assembly#GO:0120031;secretion#GO:0046903;localization#GO:0051179;localization within membrane#GO:0051668;protein localization to cell junction#GO:1902414;organelle assembly#GO:0070925;vesicle-mediated transport#GO:0016192;cellular component assembly#GO:0022607;cellular process#GO:0009987;cell projection assembly#GO:0030031;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;establishment of protein localization to membrane#GO:0090150;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;neurotransmitter receptor transport to postsynaptic membrane#GO:0098969;endosomal transport#GO:0016197;exocytosis#GO:0006887;protein localization to synapse#GO:0035418;cellular component organization or biogenesis#GO:0071840;protein localization to cell periphery#GO:1990778;export from cell#GO:0140352;cell projection organization#GO:0030030;endocytic recycling#GO:0032456;cilium assembly#GO:0060271;cellular component organization#GO:0016043;protein localization to membrane#GO:0072657;regulation of biological quality#GO:0065008;cilium organization#GO:0044782;protein transport#GO:0015031;secretion by cell#GO:0032940;cellular localization#GO:0051641 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;coated vesicle#GO:0030135;intracellular organelle#GO:0043229;endosome#GO:0005768;trans-Golgi network transport vesicle#GO:0030140;plasma membrane#GO:0005886;cytoplasm#GO:0005737;transport vesicle#GO:0030133;endomembrane system#GO:0012505;cell periphery#GO:0071944;membrane#GO:0016020;Golgi-associated vesicle#GO:0005798;Golgi apparatus#GO:0005794;clathrin-coated vesicle#GO:0030136 Huntington disease#P00029>Rab8#P00783 HUMAN|HGNC=7706|UniProtKB=O95298 O95298 NDUFC2 PTHR13099:SF0 NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B14.5B NADH DEHYDROGENASE [UBIQUINONE] 1 SUBUNIT C2-RELATED transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;respiratory chain complex I#GO:0045271;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;oxidoreductase complex#GO:1990204;membrane#GO:0016020;membrane protein complex#GO:0098796;respiratory chain complex#GO:0098803 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HUMAN|HGNC=8045|UniProtKB=Q9Y266 Q9Y266 NUDC PTHR12356:SF3 NUCLEAR MOVEMENT PROTEIN NUDC NUCLEAR MIGRATION PROTEIN NUDC primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein maturation#GO:0051604;gene expression#GO:0010467;protein folding#GO:0006457;biosynthetic process#GO:0009058;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 microtubule or microtubule-binding cytoskeletal protein#PC00157;cytoskeletal protein#PC00085 HUMAN|HGNC=15831|UniProtKB=P81877 P81877 SSBP2 PTHR12610:SF23 SINGLE STRANDED DNA BINDING PROTEIN SINGLE-STRANDED DNA-BINDING PROTEIN 2 DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of transcription by RNA polymerase II#GO:0045944 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 DNA metabolism protein#PC00009 HUMAN|HGNC=25234|UniProtKB=Q9BUV0 Q9BUV0 RSRP1 PTHR47622:SF1 ARGININE/SERINE-RICH PROTEIN 1 ARGININE_SERINE-RICH PROTEIN 1 HUMAN|HGNC=6752|UniProtKB=P20645 P20645 M6PR PTHR15071:SF29 MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER CATION-DEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR protein-containing complex binding#GO:0044877;binding#GO:0005488 transport#GO:0006810;intracellular protein transport#GO:0006886;vacuolar transport#GO:0007034;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;protein targeting to vacuole#GO:0006623;macromolecule localization#GO:0033036;protein localization to vacuole#GO:0072665;lysosomal transport#GO:0007041;protein transport#GO:0015031;cellular localization#GO:0051641;localization#GO:0051179;protein localization to lysosome#GO:0061462;protein localization to organelle#GO:0033365;protein targeting#GO:0006605;establishment of protein localization to vacuole#GO:0072666 cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;Golgi apparatus#GO:0005794;late endosome#GO:0005770;endomembrane system#GO:0012505;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;Golgi apparatus subcompartment#GO:0098791 membrane traffic protein#PC00150 HUMAN|HGNC=15363|UniProtKB=Q8NH40 Q8NH40 OR6S1 PTHR26454:SF7 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 6S1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=25608|UniProtKB=Q5VIR6 Q5VIR6 VPS53 PTHR12820:SF0 VACUOLAR SORTING PROTEIN 53 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 HOMOLOG cellular process#GO:0009987;establishment of localization in cell#GO:0051649;retrograde transport, endosome to Golgi#GO:0042147;cytosolic transport#GO:0016482;vesicle-mediated transport#GO:0016192;transport#GO:0006810;intracellular transport#GO:0046907;endosomal transport#GO:0016197;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;vesicle tethering complex#GO:0099023;vesicle#GO:0031982;intracellular vesicle#GO:0097708;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226 membrane traffic protein#PC00150 HUMAN|HGNC=19970|UniProtKB=O75586 O75586 MED6 PTHR13104:SF0 MED-6-RELATED MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 6 transcription coactivator activity#GO:0003713;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;RNA polymerase II transcription regulator complex#GO:0090575;core mediator complex#GO:0070847;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;mediator complex#GO:0016592;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HUMAN|HGNC=22986|UniProtKB=Q8IZC6 Q8IZC6 COL27A1 PTHR24023:SF844 COLLAGEN ALPHA COLLAGEN ALPHA-1(XXVII) CHAIN extracellular matrix structural constituent#GO:0005201;structural molecule activity#GO:0005198 multicellular organismal process#GO:0032501;cellular component organization#GO:0016043;cellular process#GO:0009987;extracellular matrix organization#GO:0030198;anatomical structure development#GO:0048856;multicellular organism development#GO:0007275;skeletal system development#GO:0001501;cellular component organization or biogenesis#GO:0071840;external encapsulating structure organization#GO:0045229;system development#GO:0048731;extracellular structure organization#GO:0043062;animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502 cellular anatomical structure#GO:0110165;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576 extracellular matrix structural protein#PC00103;extracellular matrix protein#PC00102 Integrin signalling pathway#P00034>Collagen#P00922 HUMAN|HGNC=4487|UniProtKB=O75388 O75388 GPR32 PTHR24225:SF27 CHEMOTACTIC RECEPTOR G PROTEIN-COUPLED RECEPTOR 32-RELATED molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;immune receptor activity#GO:0140375;signaling receptor activity#GO:0038023;G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888 positive regulation of cytosolic calcium ion concentration#GO:0007204;G protein-coupled receptor signaling pathway#GO:0007186;immune system process#GO:0002376;regulation of immune response#GO:0050776;phospholipase C-activating G protein-coupled receptor signaling pathway#GO:0007200;cell communication#GO:0007154;regulation of biological quality#GO:0065008;regulation of biological process#GO:0050789;immune response-regulating signaling pathway#GO:0002764;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;signaling#GO:0023052;immune response-activating cell surface receptor signaling pathway#GO:0002429;positive regulation of immune response#GO:0050778;cell surface receptor signaling pathway#GO:0007166;regulation of response to stimulus#GO:0048583;immune response-activating signaling pathway#GO:0002757;positive regulation of immune system process#GO:0002684;activation of immune response#GO:0002253;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;positive regulation of response to stimulus#GO:0048584;immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=17321|UniProtKB=Q8TDD2 Q8TDD2 SP7 PTHR23235:SF19 KRUEPPEL-LIKE TRANSCRIPTION FACTOR TRANSCRIPTION FACTOR SP7 RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=11266|UniProtKB=Q96RM1 Q96RM1 SPRR2F PTHR48553:SF1 SMALL PROLINE-RICH PROTEIN 2E SMALL PROLINE-RICH PROTEIN 2F HUMAN|HGNC=30669|UniProtKB=Q5SQN1 Q5SQN1 SNAP47 PTHR19305:SF1 SYNAPTOSOMAL ASSOCIATED PROTEIN SYNAPTOSOMAL-ASSOCIATED PROTEIN 47 syntaxin binding#GO:0019905;SNAP receptor activity#GO:0005484;protein binding#GO:0005515;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;SNARE binding#GO:0000149;molecular adaptor activity#GO:0060090 vesicle organization#GO:0016050;protein-containing complex organization#GO:0043933;exocytosis#GO:0006887;vesicle-mediated transport in synapse#GO:0099003;cellular component organization or biogenesis#GO:0071840;exocytic process#GO:0140029;regulated exocytosis#GO:0045055;vesicle fusion to plasma membrane#GO:0099500;organelle membrane fusion#GO:0090174;neurotransmitter transport#GO:0006836;endomembrane system organization#GO:0010256;vesicle-mediated transport#GO:0016192;cellular component assembly#GO:0022607;organelle fusion#GO:0048284;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;synaptic vesicle exocytosis#GO:0016079;synaptic signaling#GO:0099536;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;secretion by cell#GO:0032940;cellular localization#GO:0051641;export from cell#GO:0140352;signaling#GO:0023052;protein-containing complex assembly#GO:0065003;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;establishment of localization#GO:0051234;synaptic vesicle cycle#GO:0099504;transport#GO:0006810;neurotransmitter secretion#GO:0007269;cell-cell signaling#GO:0007267;membrane organization#GO:0061024;biological regulation#GO:0065007;synaptic vesicle membrane organization#GO:0048499;membrane fusion#GO:0061025;secretion#GO:0046903;localization#GO:0051179;cell communication#GO:0007154;synaptic vesicle fusion to presynaptic active zone membrane#GO:0031629;trans-synaptic signaling#GO:0099537;signal release#GO:0023061;vesicle fusion#GO:0006906;anterograde trans-synaptic signaling#GO:0098916;chemical synaptic transmission#GO:0007268;signal release from synapse#GO:0099643 cytoplasm#GO:0005737;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;SNARE complex#GO:0031201;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;membrane protein complex#GO:0098796;intracellular anatomical structure#GO:0005622 SNARE protein#PC00034;membrane traffic protein#PC00150 HUMAN|HGNC=25900|UniProtKB=Q9H425 Q9H425 C1orf198 PTHR34394:SF1 SIMILAR TO RIKEN CDNA 2310022B05 SIMILAR TO HUMAN CHROMOSOME 1 OPEN READING FRAME 198 HUMAN|HGNC=9522|UniProtKB=Q15238 Q15238 PSG5 PTHR44337:SF20 CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 8 CELL ADHESION MOLECULE CEACAM5-RELATED cellular process#GO:0009987;heterophilic cell-cell adhesion#GO:0007157;cell adhesion#GO:0007155;cell-cell adhesion#GO:0098609;homophilic cell-cell adhesion#GO:0007156 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 immunoglobulin superfamily cell adhesion molecule#PC00125;cell adhesion molecule#PC00069 HUMAN|HGNC=2985|UniProtKB=Q14183 Q14183 DOC2A PTHR45729:SF1 RABPHILIN, ISOFORM A DOUBLE C2-LIKE DOMAIN-CONTAINING PROTEIN ALPHA regulation of exocytosis#GO:0017157;regulation of secretion#GO:0051046;cell communication#GO:0007154;localization#GO:0051179;secretion#GO:0046903;signal release#GO:0023061;trans-synaptic signaling#GO:0099537;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;signal release from synapse#GO:0099643;chemical synaptic transmission#GO:0007268;establishment of localization#GO:0051234;transport#GO:0006810;synaptic vesicle cycle#GO:0099504;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;neurotransmitter secretion#GO:0007269;positive regulation of cellular process#GO:0048522;secretion by cell#GO:0032940;regulation of secretion by cell#GO:1903530;positive regulation of organelle organization#GO:0010638;cellular localization#GO:0051641;positive regulation of cellular component organization#GO:0051130;positive regulation of secretion#GO:0051047;signaling#GO:0023052;export from cell#GO:0140352;regulation of cellular component organization#GO:0051128;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;regulation of transport#GO:0051049;exocytosis#GO:0006887;positive regulation of vesicle fusion#GO:0031340;regulation of localization#GO:0032879;vesicle-mediated transport in synapse#GO:0099003;regulated exocytosis#GO:0045055;neurotransmitter transport#GO:0006836;vesicle-mediated transport#GO:0016192;positive regulation of secretion by cell#GO:1903532;establishment of localization in cell#GO:0051649;positive regulation of transport#GO:0051050;synaptic vesicle exocytosis#GO:0016079;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;synaptic signaling#GO:0099536 exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;synaptic vesicle#GO:0008021;synaptic vesicle membrane#GO:0030672;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;extrinsic component of membrane#GO:0019898;cell junction#GO:0030054;presynapse#GO:0098793;secretory vesicle#GO:0099503;membrane#GO:0016020;vesicle membrane#GO:0012506;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;transport vesicle membrane#GO:0030658;transport vesicle#GO:0030133 HUMAN|HGNC=24172|UniProtKB=Q96BR9 Q96BR9 ZBTB8A PTHR46105:SF12 AGAP004733-PA ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 8A double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=6570|UniProtKB=O00182 O00182 LGALS9 PTHR11346:SF170 GALECTIN GALECTIN-9 carbohydrate derivative binding#GO:0097367;binding#GO:0005488;carbohydrate binding#GO:0030246 negative regulation of multicellular organismal process#GO:0051241;regulation of T cell proliferation#GO:0042129;regulation of macromolecule metabolic process#GO:0060255;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of cell-cell adhesion#GO:0022407;negative regulation of leukocyte cell-cell adhesion#GO:1903038;negative regulation of T cell activation#GO:0050868;positive regulation of biosynthetic process#GO:0009891;regulation of cell population proliferation#GO:0042127;regulation of cytokine production#GO:0001817;negative regulation of cell population proliferation#GO:0008285;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of cell adhesion#GO:0007162;regulation of lymphocyte proliferation#GO:0050670;regulation of cell adhesion#GO:0030155;negative regulation of immune system process#GO:0002683;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of leukocyte cell-cell adhesion#GO:1903037;negative regulation of cellular process#GO:0048523;regulation of biosynthetic process#GO:0009889;negative regulation of cell activation#GO:0050866;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;negative regulation of biological process#GO:0048519;regulation of leukocyte activation#GO:0002694;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;regulation of cell activation#GO:0050865;negative regulation of metabolic process#GO:0009892;regulation of lymphocyte activation#GO:0051249;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of mononuclear cell proliferation#GO:0032944;positive regulation of biological process#GO:0048518;negative regulation of cell-cell adhesion#GO:0022408;positive regulation of macromolecule metabolic process#GO:0010604;regulation of T cell activation#GO:0050863;regulation of multicellular organismal process#GO:0051239;negative regulation of lymphocyte activation#GO:0051250;negative regulation of leukocyte activation#GO:0002695;regulation of leukocyte proliferation#GO:0070663;negative regulation of T cell proliferation#GO:0042130 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 extracellular matrix protein#PC00102 HUMAN|HGNC=11448|UniProtKB=Q9P2R7 Q9P2R7 SUCLA2 PTHR11815:SF14 SUCCINYL-COA SYNTHETASE BETA CHAIN SUCCINATE--COA LIGASE [ADP-FORMING] SUBUNIT BETA, MITOCHONDRIAL ligase activity#GO:0016874;ligase activity, forming carbon-sulfur bonds#GO:0016877;catalytic activity#GO:0003824 energy derivation by oxidation of organic compounds#GO:0015980;acyl-CoA metabolic process#GO:0006637;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091;nucleobase-containing compound metabolic process#GO:0006139;tricarboxylic acid cycle#GO:0006099;sulfur compound metabolic process#GO:0006790;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;cellular respiration#GO:0045333;aerobic respiration#GO:0009060;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739 ligase#PC00142 HUMAN|HGNC=1851|UniProtKB=P49450 P49450 CENPA PTHR11426:SF255 HISTONE H3 HISTONE H3-LIKE CENTROMERIC PROTEIN A cellular component organization#GO:0016043;sister chromatid segregation#GO:0000819;nuclear chromosome segregation#GO:0098813;membraneless organelle assembly#GO:0140694;cell cycle#GO:0007049;mitotic nuclear division#GO:0140014;cell cycle process#GO:0022402;mitotic metaphase chromosome alignment#GO:0007080;protein-containing complex assembly#GO:0065003;mitotic cell cycle#GO:0000278;organelle localization#GO:0051640;nuclear division#GO:0000280;organelle assembly#GO:0070925;kinetochore assembly#GO:0051382;organelle fission#GO:0048285;localization#GO:0051179;kinetochore organization#GO:0051383;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;mitotic sister chromatid segregation#GO:0000070;cellular process#GO:0009987;cellular component assembly#GO:0022607;chromosome localization#GO:0050000;metaphase chromosome alignment#GO:0051310;chromosome segregation#GO:0007059;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;chromosome organization#GO:0051276;mitotic cell cycle process#GO:1903047 intracellular membraneless organelle#GO:0043232;nucleosome#GO:0000786;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;protein-DNA complex#GO:0032993;chromatin#GO:0000785;chromosome#GO:0005694;intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;chromosome, centromeric region#GO:0000775 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=11822|UniProtKB=P35625 P35625 TIMP3 PTHR11844:SF22 METALLOPROTEASE INHIBITOR METALLOPROTEINASE INHIBITOR 3 molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;peptidase regulator activity#GO:0061134;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414;molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866;enzyme inhibitor activity#GO:0004857 regulation of proteolysis#GO:0030162;negative regulation of cellular process#GO:0048523;regulation of catabolic process#GO:0009894;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;response to hormone#GO:0009725;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;response to chemical#GO:0042221;negative regulation of protein catabolic process#GO:0042177;response to cytokine#GO:0034097;negative regulation of catabolic process#GO:0009895;response to peptide#GO:1901652;regulation of protein catabolic process#GO:0042176;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;response to endogenous stimulus#GO:0009719;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;regulation of macromolecule metabolic process#GO:0060255;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012 protease inhibitor#PC00191;protein-binding activity modulator#PC00095 HUMAN|HGNC=25567|UniProtKB=Q9NVI7 Q9NVI7 ATAD3A PTHR23075:SF5 PUTATIVE ATP-ASE ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 3A mitochondrion organization#GO:0007005;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996 mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=19712|UniProtKB=A7MBM2 A7MBM2 DISP2 PTHR45951:SF2 PROTEIN DISPATCHED-RELATED PROTEIN DISPATCHED HOMOLOG 2 cell communication#GO:0007154;smoothened signaling pathway#GO:0007224;cell surface receptor signaling pathway#GO:0007166;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;membrane#GO:0016020 HUMAN|HGNC=10884|UniProtKB=O14893 O14893 GEMIN2 PTHR12794:SF6 GEMIN2 GEM-ASSOCIATED PROTEIN 2 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;mRNA processing#GO:0006397;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;cellular component assembly#GO:0022607;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;protein-containing complex organization#GO:0043933;protein-RNA complex organization#GO:0071826;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;mRNA splicing, via spliceosome#GO:0000398;protein-containing complex assembly#GO:0065003;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;spliceosomal snRNP assembly#GO:0000387;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA metabolic process#GO:0016070;protein-RNA complex assembly#GO:0022618;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377 Sm-like protein family complex#GO:0120114;membrane-bounded organelle#GO:0043227;SMN complex#GO:0032797;SMN-Sm protein complex#GO:0034719;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 RNA splicing factor#PC00148 HUMAN|HGNC=14476|UniProtKB=Q9NX20 Q9NX20 MRPL16 PTHR12220:SF13 50S/60S RIBOSOMAL PROTEIN L16 LARGE RIBOSOMAL SUBUNIT PROTEIN UL16M RNA binding#GO:0003723;structural molecule activity#GO:0005198;nucleic acid binding#GO:0003676;structural constituent of ribosome#GO:0003735;rRNA binding#GO:0019843;binding#GO:0005488 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;gene expression#GO:0010467;mitochondrial translation#GO:0032543;protein biosynthetic process#GO:0160307;translation#GO:0006412;metabolic process#GO:0008152;mitochondrial gene expression#GO:0140053;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 organelle lumen#GO:0043233;mitochondrion#GO:0005739;ribosome#GO:0005840;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;mitochondrial ribosome#GO:0005761;intracellular anatomical structure#GO:0005622;organellar ribosome#GO:0000313;membrane-enclosed lumen#GO:0031974;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;mitochondrial large ribosomal subunit#GO:0005762;membraneless organelle#GO:0043228 ribosomal protein#PC00202 Oxytocin receptor mediated signaling pathway#P04391>SNARE Complex#P04532;5HT3 type receptor mediated signaling pathway#P04375>SNARE Complex#P04423;Opioid prodynorphin pathway#P05916>SNARE Complex#P05996;Beta2 adrenergic receptor signaling pathway#P04378>SNARE Complex#P04442;Dopamine receptor mediated signaling pathway#P05912>SNARE Complex#P05956;Thyrotropin-releasing hormone receptor signaling pathway#P04394>SNARE Complex#P04582;Beta3 adrenergic receptor signaling pathway#P04379>SNARE Complex#P04447;Cortocotropin releasing factor receptor signaling pathway#P04380>SNARE Complex#P04457;Beta1 adrenergic receptor signaling pathway#P04377>SNARE Complex#P04435;5HT1 type receptor mediated signaling pathway#P04373>SNARE Complex#P04405;5HT4 type receptor mediated signaling pathway#P04376>SNARE Complex#P04428;5HT2 type receptor mediated signaling pathway#P04374>SNARE Complex#P04415;Opioid proenkephalin pathway#P05915>SNARE Complex#P05986;Opioid proopiomelanocortin pathway#P05917>SNARE Complex#P06005 HUMAN|HGNC=17836|UniProtKB=Q5I0G3 Q5I0G3 MDH1B PTHR23382:SF1 MALATE DEHYDROGENASE MALATE DEHYDROGENASE 1B-RELATED catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614 nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;nucleobase-containing compound metabolic process#GO:0006139;NAD+ metabolic process#GO:0019674;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;nicotinamide nucleotide metabolic process#GO:0046496;nucleotide metabolic process#GO:0009117;oxoacid metabolic process#GO:0043436;pyridine-containing compound metabolic process#GO:0072524;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;carboxylic acid metabolic process#GO:0019752;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 dehydrogenase#PC00092 HUMAN|HGNC=26188|UniProtKB=Q8N2U9 Q8N2U9 SLC66A2 PTHR14856:SF10 PQ-LOOP REPEAT-CONTAINING PROTEIN 1-LIKE PROTEIN SOLUTE CARRIER FAMILY 66 MEMBER 2 lipid transport#GO:0006869;vesicle-mediated transport#GO:0016192;phospholipid translocation#GO:0045332;phospholipid transport#GO:0015914;membrane organization#GO:0061024;biological regulation#GO:0065007;macromolecule localization#GO:0033036;retrograde transport, endosome to Golgi#GO:0042147;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;endosomal transport#GO:0016197;regulation of membrane lipid distribution#GO:0097035;intracellular transport#GO:0046907;transport#GO:0006810;organophosphate ester transport#GO:0015748;lipid translocation#GO:0034204;cytosolic transport#GO:0016482;cellular component organization#GO:0016043;localization#GO:0051179;cellular localization#GO:0051641;regulation of biological quality#GO:0065008;lipid localization#GO:0010876 intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;endosome#GO:0005768;endosome membrane#GO:0010008;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;vesicle membrane#GO:0012506;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;trans-Golgi network membrane#GO:0032588;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;Golgi apparatus#GO:0005794;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588 HUMAN|HGNC=5649|UniProtKB=P0DP07 P0DP07 IGHV4-31 PTHR23266:SF323 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 4-30-2-RELATED antigen binding#GO:0003823;binding#GO:0005488 immune response#GO:0006955;adaptive immune response#GO:0002250;response to stimulus#GO:0050896;immune effector process#GO:0002252;immune system process#GO:0002376;immunoglobulin mediated immune response#GO:0016064;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=25818|UniProtKB=Q9H8M2 Q9H8M2 BRD9 PTHR22881:SF4 BROMODOMAIN CONTAINING PROTEIN BROMODOMAIN-CONTAINING PROTEIN 9 histone reader activity#GO:0140566;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;chromatin-protein adaptor activity#GO:0140463 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=20361|UniProtKB=Q969W0 Q969W0 SPTSSA PTHR47084:SF1 SERINE PALMITOYLTRANSFERASE SMALL SUBUNIT A SERINE PALMITOYLTRANSFERASE SMALL SUBUNIT A acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;palmitoyltransferase activity#GO:0016409 cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;ceramide biosynthetic process#GO:0046513;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;sphingolipid metabolic process#GO:0006665;sphingolipid biosynthetic process#GO:0030148;ceramide metabolic process#GO:0006672 protein-containing complex#GO:0032991;transferase complex#GO:1990234;catalytic complex#GO:1902494 protein modifying enzyme#PC00260 HUMAN|HGNC=14781|UniProtKB=Q8NGH5 Q8NGH5 OR56A1 PTHR26450:SF425 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 56A1 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=26135|UniProtKB=Q9H707 Q9H707 ZNF552 PTHR24377:SF702 IP01015P-RELATED ZINC FINGER PROTEIN 552 binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=8007|UniProtKB=Q99748 Q99748 NRTN PTHR12173:SF3 GDNF SUBFAMILY OF TGF-BETA FAMILY NEURTURIN signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;signaling receptor regulator activity#GO:0030545;growth factor activity#GO:0008083;receptor ligand activity#GO:0048018 biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;signal transduction#GO:0007165;cellular process#GO:0009987;neuron projection development#GO:0031175;neurogenesis#GO:0022008;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;developmental process#GO:0032502;neuron differentiation#GO:0030182;cell surface receptor signaling pathway#GO:0007166;signaling#GO:0023052;cell development#GO:0048468;response to stimulus#GO:0050896;cell differentiation#GO:0030154;cell projection organization#GO:0030030;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular component organization#GO:0016043;system development#GO:0048731;neuron development#GO:0048666;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207;growth factor#PC00112;neurotrophic factor#PC00163 HUMAN|HGNC=1304|UniProtKB=Q8TCY5 Q8TCY5 MRAP PTHR28675:SF2 MELANOCORTIN-2 RECEPTOR ACCESSORY PROTEIN 2 MELANOCORTIN-2 RECEPTOR ACCESSORY PROTEIN signaling receptor regulator activity#GO:0030545;neuropeptide receptor binding#GO:0071855;binding#GO:0005488;signaling receptor binding#GO:0005102;G protein-coupled receptor binding#GO:0001664;protein binding#GO:0005515;molecular function regulator activity#GO:0098772 localization#GO:0051179;cellular localization#GO:0051641;localization within membrane#GO:0051668;regulation of signaling#GO:0023051;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;protein localization to membrane#GO:0072657;protein localization to plasma membrane#GO:0072659;regulation of biological process#GO:0050789;intracellular protein localization#GO:0008104;protein localization to cell periphery#GO:1990778;regulation of G protein-coupled receptor signaling pathway#GO:0008277;regulation of response to stimulus#GO:0048583;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;macromolecule localization#GO:0033036;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=6309|UniProtKB=O60938 O60938 KERA PTHR45712:SF13 AGAP008170-PA KERATOCAN extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=15299|UniProtKB=Q8NH69 Q8NH69 OR5W2 PTHR26452:SF974 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5W2 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 nervous system process#GO:0050877;sensory perception#GO:0007600;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=26620|UniProtKB=Q6Q759 Q6Q759 SPAG17 PTHR21963:SF1 PF6 SPERM-ASSOCIATED ANTIGEN 17 cell projection organization#GO:0030030;microtubule-based movement#GO:0007018;cellular component organization#GO:0016043;cilium assembly#GO:0060271;axoneme assembly#GO:0035082;cilium organization#GO:0044782;localization#GO:0051179;microtubule cytoskeleton organization#GO:0000226;microtubule-based transport#GO:0099111;cilium movement#GO:0003341;microtubule bundle formation#GO:0001578;organelle assembly#GO:0070925;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;transport#GO:0006810;plasma membrane bounded cell projection assembly#GO:0120031 intracellular organelle#GO:0043229;cilium#GO:0005929;cytoskeleton#GO:0005856;axonemal central apparatus#GO:1990716;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;axoneme#GO:0005930;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;ciliary plasm#GO:0097014;organelle#GO:0043226 HUMAN|HGNC=27614|UniProtKB=Q0D2J5 Q0D2J5 ZNF763 PTHR24390:SF250 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 763 double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=26061|UniProtKB=Q6IQ21 Q6IQ21 ZNF770 PTHR24376:SF257 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 770 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=17958|UniProtKB=Q6SPF0 Q6SPF0 SAMD1 PTHR36292:SF2 UPF0575 PROTEIN C19ORF67 STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 1 binding#GO:0005488;chromatin binding#GO:0003682 negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=2188|UniProtKB=Q99715 Q99715 COL12A1 PTHR24020:SF17 COLLAGEN ALPHA COLLAGEN ALPHA-1(XII) CHAIN cellular process#GO:0009987;endoderm formation#GO:0001706;embryo development#GO:0009790;multicellular organismal process#GO:0032501;tissue development#GO:0009888;developmental process#GO:0032502;anatomical structure formation involved in morphogenesis#GO:0048646;endoderm development#GO:0007492;multicellular organism development#GO:0007275;embryonic morphogenesis#GO:0048598;cellular developmental process#GO:0048869;anatomical structure morphogenesis#GO:0009653;gastrulation#GO:0007369;cell differentiation#GO:0030154;formation of primary germ layer#GO:0001704;animal gross anatomical part developmental process#GO:0160108;anatomical structure development#GO:0048856 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012 extracellular matrix structural protein#PC00103 Integrin signalling pathway#P00034>Collagen#P00922;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>EMC#P00863 HUMAN|HGNC=41948|UniProtKB=A6NDL7 A6NDL7 METTL21EP PTHR14614:SF1 HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN METHYLTRANSFERASE-LIKE PROTEIN 21E methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;N-methyltransferase activity#GO:0008170;protein-lysine N-methyltransferase activity#GO:0016279;lysine N-methyltransferase activity#GO:0016278;transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein methyltransferase activity#GO:0008276;catalytic activity, acting on a protein#GO:0140096 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 protein modifying enzyme#PC00260 HUMAN|HGNC=13085|UniProtKB=O15209 O15209 ZBTB22 PTHR46105:SF14 AGAP004733-PA ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 22 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=30286|UniProtKB=Q96NL0 Q96NL0 RUNDC3B PTHR46251:SF1 RUN DOMAIN-CONTAINING 3 PROTEIN RUNDC3 RUN DOMAIN-CONTAINING PROTEIN 3B HUMAN|HGNC=9105|UniProtKB=Q9ULL4 Q9ULL4 PLXNB3 PTHR22625:SF33 PLEXIN PLEXIN-B3 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell junction organization#GO:0034330;regulation of cellular process#GO:0050794;positive regulation of neurogenesis#GO:0050769;regulation of developmental process#GO:0050793;regulation of neurogenesis#GO:0050767;cellular response to stimulus#GO:0051716;regulation of nervous system development#GO:0051960;anatomical structure development#GO:0048856;cell communication#GO:0007154;regulation of cell motility#GO:2000145;system development#GO:0048731;positive regulation of cell projection organization#GO:0031346;synapse organization#GO:0050808;regulation of cell adhesion#GO:0030155;multicellular organismal process#GO:0032501;negative regulation of cell adhesion#GO:0007162;regulation of locomotion#GO:0040012;negative regulation of cell motility#GO:2000146;biological regulation#GO:0065007;regulation of cell development#GO:0060284;positive regulation of cellular process#GO:0048522;regulation of plasma membrane bounded cell projection organization#GO:0120035;negative regulation of cellular process#GO:0048523;regulation of cell projection organization#GO:0031344;regulation of cell differentiation#GO:0045595;developmental process#GO:0032502;positive regulation of developmental process#GO:0051094;regulation of cell migration#GO:0030334;synapse assembly#GO:0007416;response to stimulus#GO:0050896;positive regulation of nervous system development#GO:0051962;regulation of cellular component organization#GO:0051128;signaling#GO:0023052;cellular component organization#GO:0016043;cell junction assembly#GO:0034329;negative regulation of biological process#GO:0048519;regulation of multicellular organismal development#GO:2000026;positive regulation of multicellular organismal process#GO:0051240;regulation of cell shape#GO:0008360;regulation of biological process#GO:0050789;regulation of biological quality#GO:0065008;positive regulation of axonogenesis#GO:0050772;animal gross anatomical part developmental process#GO:0160108;positive regulation of cellular component organization#GO:0051130;cellular component assembly#GO:0022607;regulation of multicellular organismal process#GO:0051239;nervous system development#GO:0007399;positive regulation of cell development#GO:0010720;negative regulation of locomotion#GO:0040013;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;regulation of neuron projection development#GO:0010975;regulation of anatomical structure morphogenesis#GO:0022603;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;regulation of axonogenesis#GO:0050770;negative regulation of cell migration#GO:0030336;positive regulation of cell differentiation#GO:0045597;cell surface receptor signaling pathway#GO:0007166 plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;signaling receptor complex#GO:0043235;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=2297|UniProtKB=P48052 P48052 CPA2 PTHR11705:SF71 PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B CARBOXYPEPTIDASE A2 peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;metalloexopeptidase activity#GO:0008235;catalytic activity#GO:0003824;carboxypeptidase activity#GO:0004180;exopeptidase activity#GO:0008238;metallocarboxypeptidase activity#GO:0004181;hydrolase activity#GO:0016787;metallopeptidase activity#GO:0008237 primary metabolic process#GO:0044238;proteolysis#GO:0006508;metabolic process#GO:0008152;cellular process#GO:0009987;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 HUMAN|HGNC=7414|UniProtKB=P00846 P00846 MT-ATP6 PTHR11410:SF0 ATP SYNTHASE SUBUNIT A ATP SYNTHASE F(0) COMPLEX SUBUNIT A monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;proton-transporting ATP synthase activity, rotational mechanism#GO:0046933;ligase activity#GO:0016874;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;proton transmembrane transporter activity#GO:0015078;catalytic activity#GO:0003824;passive transmembrane transporter activity#GO:0022803;proton channel activity#GO:0015252;monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216 organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;nucleoside triphosphate biosynthetic process#GO:0009142;carbohydrate derivative metabolic process#GO:1901135;purine ribonucleoside triphosphate metabolic process#GO:0009205;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;purine ribonucleoside triphosphate biosynthetic process#GO:0009206;nucleoside phosphate biosynthetic process#GO:1901293;primary metabolic process#GO:0044238;purine nucleoside triphosphate metabolic process#GO:0009144;purine nucleoside triphosphate biosynthetic process#GO:0009145;proton motive force-driven ATP synthesis#GO:0015986;nucleoside triphosphate metabolic process#GO:0009141;nucleoside phosphate metabolic process#GO:0006753;organophosphate biosynthetic process#GO:0090407;ribose phosphate biosynthetic process#GO:0046390;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;ATP metabolic process#GO:0046034;metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing compound biosynthetic process#GO:0034654;ATP biosynthetic process#GO:0006754;ribonucleoside triphosphate biosynthetic process#GO:0009201;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;phosphorus metabolic process#GO:0006793;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;small molecule metabolic process#GO:0044281;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;ribonucleotide metabolic process#GO:0009259;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide biosynthetic process#GO:0009165 transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;proton-transporting two-sector ATPase complex#GO:0016469;cation channel complex#GO:0034703;catalytic complex#GO:1902494;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;proton-transporting ATP synthase complex#GO:0045259;membrane#GO:0016020;membrane protein complex#GO:0098796;respiratory chain complex#GO:0098803 primary active transporter#PC00068;ATP synthase#PC00002 ATP synthesis#P02721>ATP synthetase F0#P02797 HUMAN|HGNC=2738|UniProtKB=O43143 O43143 DHX15 PTHR18934:SF95 ATP-DEPENDENT RNA HELICASE ATP-DEPENDENT RNA HELICASE DHX15 RNA binding#GO:0003723;ATP-dependent activity#GO:0140657;binding#GO:0005488;nucleic acid binding#GO:0003676;isomerase activity#GO:0016853;helicase activity#GO:0004386;macromolecular conformation isomerase activity#GO:0120543;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity#GO:0003824 spliceosomal complex#GO:0005681;nucleus#GO:0005634;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 RNA helicase#PC00032;RNA metabolism protein#PC00031 HUMAN|HGNC=25892|UniProtKB=Q5VU57 Q5VU57 AGBL4 PTHR12756:SF9 CYTOSOLIC CARBOXYPEPTIDASE CYTOSOLIC CARBOXYPEPTIDASE 6 exopeptidase activity#GO:0008238;protein binding#GO:0005515;metallocarboxypeptidase activity#GO:0004181;hydrolase activity#GO:0016787;carboxypeptidase activity#GO:0004180;binding#GO:0005488;metallopeptidase activity#GO:0008237;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;catalytic activity#GO:0003824;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;metalloexopeptidase activity#GO:0008235 cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;microtubule cytoskeleton#GO:0015630;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cilium#GO:0005929;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815 metalloprotease#PC00153 HUMAN|HGNC=26255|UniProtKB=Q5BVD1 Q5BVD1 TTMP PTHR14636:SF1 TPA-INDUCED TRANSMEMBRANE PROTEIN TPA-INDUCED TRANSMEMBRANE PROTEIN HUMAN|HGNC=707|UniProtKB=P59998 P59998 ARPC4 PTHR22629:SF0 ARP2/3 COMPLEX 20 KD SUBUNIT ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 4 structural molecule activity#GO:0005198;protein complex scaffold activity#GO:0140378 actin filament-based process#GO:0030029;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cellular component organization or biogenesis#GO:0071840;Arp2/3 complex-mediated actin nucleation#GO:0034314;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;cytoskeleton organization#GO:0007010;actin nucleation#GO:0045010;actin cytoskeleton organization#GO:0030036 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;Arp2/3 protein complex#GO:0005885;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;actin cytoskeleton#GO:0015629 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Arp2/3#P00876;Cytoskeletal regulation by Rho GTPase#P00016>ARP2/3#P00511 HUMAN|HGNC=24989|UniProtKB=Q9NZL4 Q9NZL4 HSPBP1 PTHR19316:SF18 PROTEIN FOLDING REGULATOR HSP70-BINDING PROTEIN 1 molecular function regulator activity#GO:0098772;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 HUMAN|HGNC=30087|UniProtKB=Q5T7W7 Q5T7W7 TSTD2 PTHR43268:SF6 THIOSULFATE SULFURTRANSFERASE/RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 2 THIOSULFATE SULFURTRANSFERASE_RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 2 transferase#PC00220 HUMAN|HGNC=18374|UniProtKB=Q8WWQ2 Q8WWQ2 HPSE2 PTHR46145:SF1 HEPARANASE INACTIVE HEPARANASE-2 external encapsulating structure organization#GO:0045229;cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;cellular process#GO:0009987;extracellular structure organization#GO:0043062;cellular component organization#GO:0016043 extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical structure#GO:0110165 glycosidase#PC00110 HUMAN|HGNC=14623|UniProtKB=Q69YH5 Q69YH5 CDCA2 PTHR21603:SF16 ANTIGEN KI-67-LIKE PROTEIN CELL DIVISION CYCLE-ASSOCIATED PROTEIN 2 molecular condensate scaffold activity#GO:0140693;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 meiotic cell cycle#GO:0051321;chromosome segregation#GO:0007059;regulation of mitotic nuclear division#GO:0007088;regulation of mitotic cell cycle#GO:0007346;cellular process#GO:0009987;biological regulation#GO:0065007;regulation of cell cycle process#GO:0010564;regulation of nuclear division#GO:0051783;sexual reproduction#GO:0019953;cell cycle#GO:0007049;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;cell cycle process#GO:0022402;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of cell cycle#GO:0051726;reproductive process#GO:0022414 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694;nucleus#GO:0005634;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;condensed chromosome#GO:0000793;intracellular organelle#GO:0043229 HUMAN|HGNC=13600|UniProtKB=Q9UKT6 Q9UKT6 FBXL21P PTHR16134:SF2 F-BOX/TPR REPEAT PROTEIN POF3 F-BOX_LRR-REPEAT PROTEIN 21-RELATED ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 catabolic process#GO:0009056;response to light stimulus#GO:0009416;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;modification-dependent protein catabolic process#GO:0019941;response to abiotic stimulus#GO:0009628;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;biological regulation#GO:0065007;proteasomal protein catabolic process#GO:0010498;regulation of circadian rhythm#GO:0042752;cellular process#GO:0009987;response to radiation#GO:0009314;response to external stimulus#GO:0009605;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;photoperiodism#GO:0009648;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;SCF ubiquitin ligase complex#GO:0019005;intracellular membrane-bounded organelle#GO:0043231;cullin-RING ubiquitin ligase complex#GO:0031461;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;nucleus#GO:0005634;cytosol#GO:0005829 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=5294|UniProtKB=P41595 P41595 HTR2B PTHR24247:SF31 5-HYDROXYTRYPTAMINE RECEPTOR 5-HYDROXYTRYPTAMINE RECEPTOR 2B neurotransmitter receptor activity#GO:0030594;transmembrane signaling receptor activity#GO:0004888;G protein-coupled amine receptor activity#GO:0008227;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023 anterograde trans-synaptic signaling#GO:0098916;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;response to nitrogen compound#GO:1901698;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;trans-synaptic signaling#GO:0099537;response to oxygen-containing compound#GO:1901700;response to chemical#GO:0042221;cellular response to nitrogen compound#GO:1901699;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;synaptic signaling#GO:0099536;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987 plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165;neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020;dendritic tree#GO:0097447;dendrite#GO:0030425 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GsPCR#P00720;5HT2 type receptor mediated signaling pathway#P04374>5HT2 Receptor#P04414 HUMAN|HGNC=5423|UniProtKB=P01563 P01563 IFNA2 PTHR11691:SF70 TYPE I INTERFERON INTERFERON ALPHA-2 cytokine activity#GO:0005125;binding#GO:0005488;signaling receptor binding#GO:0005102;cytokine receptor binding#GO:0005126;molecular function activator activity#GO:0140677;protein-containing complex binding#GO:0044877;protein binding#GO:0005515;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546 cellular response to stimulus#GO:0051716;leukocyte activation#GO:0045321;response to external biotic stimulus#GO:0043207;regulation of cellular process#GO:0050794;cell activation#GO:0001775;cytokine-mediated signaling pathway#GO:0019221;response to nitrogen compound#GO:1901698;cell communication#GO:0007154;immune response#GO:0006955;response to other organism#GO:0051707;adaptive immune response#GO:0002250;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;defense response#GO:0006952;response to external stimulus#GO:0009605;innate immune response#GO:0045087;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;T cell activation#GO:0042110;biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052;response to stimulus#GO:0050896;B cell activation involved in immune response#GO:0002312;type I interferon-mediated signaling pathway#GO:0060337;immune system process#GO:0002376;cell activation involved in immune response#GO:0002263;response to peptide#GO:1901652;cellular process#GO:0009987;lymphocyte activation involved in immune response#GO:0002285;signal transduction#GO:0007165;defense response to symbiont#GO:0140546;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;T cell activation involved in immune response#GO:0002286;defense response to other organism#GO:0098542;response to chemical#GO:0042221;lymphocyte activation#GO:0046649;response to cytokine#GO:0034097;natural killer cell activation#GO:0030101;cell surface receptor signaling pathway#GO:0007166;leukocyte activation involved in immune response#GO:0002366;immune effector process#GO:0002252;humoral immune response#GO:0006959;B cell activation#GO:0042113 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 cytokine#PC00083;interferon superfamily#PC00127 HUMAN|HGNC=12182|UniProtKB=A0A5A6 A0A5A6 TRBV11-3 PTHR23268:SF97 T-CELL RECEPTOR BETA CHAIN T CELL RECEPTOR BETA VARIABLE 11-3 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=18706|UniProtKB=Q4V328 Q4V328 GRIPAP1 PTHR18978:SF1 GRIP-1 ASSOCIATED PROTEIN 1 GRIP1-ASSOCIATED PROTEIN 1 regulation of biological quality#GO:0065008;regulation of protein localization#GO:0032880;regulation of localization#GO:0032879;regulation of transport#GO:0051049;regulation of establishment of protein localization#GO:0070201;regulation of vesicle-mediated transport#GO:0060627;regulation of protein localization to membrane#GO:1905475;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of protein transport#GO:0051223;biological regulation#GO:0065007 endosome membrane#GO:0010008;endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;early endosome#GO:0005769;vesicle#GO:0031982;postsynapse#GO:0098794;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;synaptic membrane#GO:0097060;early endosome membrane#GO:0031901;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;extrinsic component of membrane#GO:0019898;cell junction#GO:0030054;cell periphery#GO:0071944;presynapse#GO:0098793;membrane#GO:0016020;vesicle membrane#GO:0012506;presynaptic membrane#GO:0042734;cytoplasm#GO:0005737;plasma membrane#GO:0005886;glutamatergic synapse#GO:0098978;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;plasma membrane region#GO:0098590 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HUMAN|HGNC=7962|UniProtKB=P20393 P20393 NR1D1 PTHR24082:SF113 NUCLEAR HORMONE RECEPTOR NUCLEAR RECEPTOR SUBFAMILY 1 GROUP D MEMBER 1 transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023;transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;molecular transducer activity#GO:0060089;DNA binding#GO:0003677;nuclear receptor activity#GO:0004879;sequence-specific double-stranded DNA binding#GO:1990837 regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of DNA-templated transcription#GO:0006355;cell communication#GO:0007154;positive regulation of biosynthetic process#GO:0009891;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;cellular response to stimulus#GO:0051716;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;positive regulation of transcription by RNA polymerase II#GO:0045944;response to chemical#GO:0042221;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;response to hormone#GO:0009725;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;hormone-mediated signaling pathway#GO:0009755;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;cellular response to chemical stimulus#GO:0070887;signaling#GO:0023052;negative regulation of metabolic process#GO:0009892;cellular response to hormone stimulus#GO:0032870;cellular response to endogenous stimulus#GO:0071495;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;response to endogenous stimulus#GO:0009719 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C4 zinc finger nuclear receptor#PC00169 HUMAN|HGNC=8805|UniProtKB=Q15198 Q15198 PDGFRL PTHR15360:SF1 PLATELET-DERIVED GROWTH FACTOR RECEPTOR LIKE PLATELET-DERIVED GROWTH FACTOR RECEPTOR-LIKE PROTEIN tyrosine protein kinase receptor#PC00233 PDGF signaling pathway#P00047>PDGF receptor A#P01158;PDGF signaling pathway#P00047>PDGF receptor B#P01156 HUMAN|HGNC=19846|UniProtKB=Q86TY3 Q86TY3 ARMH4 PTHR21585:SF0 FULL-LENGTH CDNA CLONE CS0DC025YL05 OF NEUROBLASTOMA ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 4 HUMAN|HGNC=32681|UniProtKB=Q5MJ68 Q5MJ68 SPDYC PTHR31545:SF2 SEEDY PROTEIN A/C FAMILY MEMBER SPEEDY PROTEIN C protein kinase binding#GO:0019901;enzyme binding#GO:0019899;kinase binding#GO:0019900;binding#GO:0005488;protein binding#GO:0005515 HUMAN|HGNC=3767|UniProtKB=P35916 P35916 FLT4 PTHR24416:SF49 TYROSINE-PROTEIN KINASE RECEPTOR VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 3 transmembrane receptor protein tyrosine kinase activity#GO:0004714;molecular transducer activity#GO:0060089;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;transmembrane receptor protein kinase activity#GO:0019199;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888;phosphotransferase activity, alcohol group as acceptor#GO:0016773;growth factor binding#GO:0019838;protein binding#GO:0005515;protein kinase activity#GO:0004672;transferase activity#GO:0016740;kinase activity#GO:0016301;signaling receptor activity#GO:0038023 regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;regulation of cell migration#GO:0030334;developmental process#GO:0032502;positive regulation of locomotion#GO:0040017;positive regulation of MAPK cascade#GO:0043410;positive regulation of cell migration#GO:0030335;positive regulation of cellular process#GO:0048522;regulation of locomotion#GO:0040012;tube development#GO:0035295;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;cell migration#GO:0016477;positive regulation of response to stimulus#GO:0048584;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;system development#GO:0048731;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;regulation of cell population proliferation#GO:0042127;regulation of cell motility#GO:2000145;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;tube morphogenesis#GO:0035239;blood vessel development#GO:0001568;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;cell motility#GO:0048870;cell surface receptor signaling pathway#GO:0007166;regulation of MAPK cascade#GO:0043408;vasculature development#GO:0001944;anatomical structure formation involved in morphogenesis#GO:0048646;multicellular organism development#GO:0007275;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;regulation of signaling#GO:0023051;animal gross anatomical part developmental process#GO:0160108;regulation of intracellular signal transduction#GO:1902531;sprouting angiogenesis#GO:0002040;angiogenesis#GO:0001525;positive regulation of signaling#GO:0023056;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;blood vessel morphogenesis#GO:0048514;vascular endothelial growth factor receptor signaling pathway#GO:0048010;positive regulation of cell population proliferation#GO:0008284;positive regulation of cell motility#GO:2000147;signaling#GO:0023052;response to stimulus#GO:0050896;circulatory system development#GO:0072359 plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;signaling receptor complex#GO:0043235;membrane#GO:0016020 transmembrane signal receptor#PC00197 Angiogenesis#P00005>VEGFR-2#P00222;VEGF signaling pathway#P00056>VEGFR-2#P01403 HUMAN|HGNC=29555|UniProtKB=Q9Y2G7 Q9Y2G7 ZFP30 PTHR24377:SF246 IP01015P-RELATED ZINC FINGER PROTEIN 30 HOMOLOG DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=87|UniProtKB=Q9UKU7 Q9UKU7 ACAD8 PTHR43831:SF1 ISOBUTYRYL-COA DEHYDROGENASE ISOBUTYRYL-COA DEHYDROGENASE, MITOCHONDRIAL oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;small molecule catabolic process#GO:0044282;amino acid metabolic process#GO:0006520;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;proteinogenic amino acid metabolic process#GO:0170039 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 oxidoreductase#PC00176;dehydrogenase#PC00092 HUMAN|HGNC=11064|UniProtKB=Q92536 Q92536 SLC7A6 PTHR11785:SF398 AMINO ACID TRANSPORTER Y+L AMINO ACID TRANSPORTER 2 basic amino acid transmembrane transporter activity#GO:0015174;L-amino acid transmembrane transporter activity#GO:0015179;amino acid transmembrane transporter activity#GO:0015171;carboxylic acid transmembrane transporter activity#GO:0046943;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 cellular process#GO:0009987;transport#GO:0006810;amino acid transport#GO:0006865;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;amino acid transmembrane transport#GO:0003333 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227 HUMAN|HGNC=23077|UniProtKB=Q96FW1 Q96FW1 OTUB1 PTHR12931:SF19 UBIQUITIN THIOLESTERASE PROTEIN OTUB UBIQUITIN THIOESTERASE OTUB1 cysteine-type deubiquitinase activity#GO:0004843;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;ubiquitin binding#GO:0043130;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;binding#GO:0005488;deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787;protein binding#GO:0005515 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;response to stress#GO:0006950;response to stimulus#GO:0050896 protein modifying enzyme#PC00260;cysteine protease#PC00081;protease#PC00190 HUMAN|HGNC=29568|UniProtKB=Q7Z7J7 Q7Z7J7 LHFPL4 PTHR12489:SF14 LIPOMA HMGIC FUSION PARTNER-LIKE PROTEIN LHFPL TETRASPAN SUBFAMILY MEMBER 4 PROTEIN protein binding#GO:0005515;GABA receptor binding#GO:0050811;signaling receptor binding#GO:0005102;binding#GO:0005488 membrane organization#GO:0061024;multicellular organismal process#GO:0032501;cellular process#GO:0009987;macromolecule localization#GO:0033036;intracellular protein localization#GO:0008104;system process#GO:0003008;cellular component organization or biogenesis#GO:0071840;postsynapse organization#GO:0099173;cell junction organization#GO:0034330;sensory perception of sound#GO:0007605;cellular component organization#GO:0016043;protein localization to membrane#GO:0072657;cellular localization#GO:0051641;localization#GO:0051179;nervous system process#GO:0050877;localization within membrane#GO:0051668;synapse organization#GO:0050808;sensory perception#GO:0007600;sensory perception of mechanical stimulus#GO:0050954;receptor clustering#GO:0043113 membrane#GO:0016020;postsynapse#GO:0098794;cell periphery#GO:0071944;synapse#GO:0045202;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;plasma membrane#GO:0005886;postsynaptic membrane#GO:0045211;synaptic membrane#GO:0097060;cell junction#GO:0030054 scaffold/adaptor protein#PC00226 HUMAN|HGNC=682|UniProtKB=Q92974 Q92974 ARHGEF2 PTHR13944:SF20 AGAP007712-PA RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2 GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 intracellular signal transduction#GO:0035556;supramolecular fiber organization#GO:0097435;cell communication#GO:0007154;regulation of signaling#GO:0023051;actin filament-based process#GO:0030029;regulation of intracellular signal transduction#GO:1902531;regulation of cell communication#GO:0010646;signaling#GO:0023052;regulation of cellular process#GO:0050794;regulation of Rho protein signal transduction#GO:0035023;actin cytoskeleton organization#GO:0030036;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;regulation of small GTPase mediated signal transduction#GO:0051056;actin filament organization#GO:0007015;cellular component organization or biogenesis#GO:0071840;regulation of response to stimulus#GO:0048583;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;cytoskeleton organization#GO:0007010;small GTPase-mediated signal transduction#GO:0007264;cellular process#GO:0009987;signal transduction#GO:0007165;organelle organization#GO:0006996 intracellular organelle#GO:0043229;leading edge membrane#GO:0031256;cell projection membrane#GO:0031253;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;ruffle membrane#GO:0032587;cytoskeleton#GO:0005856;ruffle#GO:0001726;membraneless organelle#GO:0043228;membrane#GO:0016020;cell leading edge#GO:0031252;cell periphery#GO:0071944;plasma membrane region#GO:0098590;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232 HUMAN|HGNC=2355|UniProtKB=P06850 P06850 CRH PTHR15035:SF9 CORTICOLIBERIN/UROCORTIN CORTICOTROPIN-RELEASING HORMONE molecular function activator activity#GO:0140677;hormone activity#GO:0005179;protein binding#GO:0005515;hormone receptor binding#GO:0051427;signaling receptor binding#GO:0005102;binding#GO:0005488;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;G protein-coupled receptor binding#GO:0001664;neuropeptide receptor binding#GO:0071855;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018 regulation of system process#GO:0044057;regulation of transport#GO:0051049;regulation of localization#GO:0032879;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of secretion by cell#GO:1903532;signal transduction#GO:0007165;positive regulation of transport#GO:0051050;cellular process#GO:0009987;biological regulation#GO:0065007;regulation of multicellular organismal process#GO:0051239;G protein-coupled receptor signaling pathway#GO:0007186;positive regulation of hormone secretion#GO:0046887;positive regulation of secretion#GO:0051047;regulation of signaling#GO:0023051;regulation of hormone secretion#GO:0046883;cell communication#GO:0007154;regulation of secretion#GO:0051046;positive regulation of signaling#GO:0023056;regulation of secretion by cell#GO:1903530;regulation of biological quality#GO:0065008;neuropeptide signaling pathway#GO:0007218;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;positive regulation of multicellular organismal process#GO:0051240;regulation of hormone levels#GO:0010817;response to stimulus#GO:0050896;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of cell communication#GO:0010646 extracellular region#GO:0005576;cell body#GO:0044297;somatodendritic compartment#GO:0036477;neuronal cell body#GO:0043025;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207;peptide hormone#PC00179 Cortocotropin releasing factor receptor signaling pathway#P04380>CRF#P04454;Cortocotropin releasing factor receptor signaling pathway#P04380>ProCRF (Pro Corticotropin-Releasing Factor)#P04456 HUMAN|HGNC=33193|UniProtKB=Q6MZM9 Q6MZM9 PRR27 PTHR39415:SF1 PROLINE-RICH PROTEIN 27 PROLINE-RICH PROTEIN 27 HUMAN|HGNC=21355|UniProtKB=Q5VWP3 Q5VWP3 MLIP PTHR31514:SF1 MUSCULAR LMNA-INTERACTING PROTEIN MLIP MUSCULAR LMNA-INTERACTING PROTEIN HUMAN|HGNC=26659|UniProtKB=Q8NA70 Q8NA70 FAM47B PTHR47415:SF1 PROTEIN FAM47B PROTEIN FAM47B HUMAN|HGNC=6631|UniProtKB=P49257 P49257 LMAN1 PTHR12223:SF32 VESICULAR MANNOSE-BINDING LECTIN PROTEIN ERGIC-53 monosaccharide binding#GO:0048029;carbohydrate binding#GO:0030246;small molecule binding#GO:0036094;binding#GO:0005488 vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;transport#GO:0006810 endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;coated vesicle#GO:0030135;COPII-coated ER to Golgi transport vesicle#GO:0030134;vesicle#GO:0031982;intracellular vesicle#GO:0097708;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endoplasmic reticulum#GO:0005783;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane#GO:0016020;cytoplasm#GO:0005737;endomembrane system#GO:0012505 membrane traffic protein#PC00150 HUMAN|HGNC=11112|UniProtKB=Q8NDV3 Q8NDV3 SMC1B PTHR18937:SF147 STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 1B DNA binding#GO:0003677;nucleic acid binding#GO:0003676;binding#GO:0005488 organelle organization#GO:0006996;cell cycle#GO:0007049;cellular component organization#GO:0016043;cell cycle process#GO:0022402;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;sister chromatid cohesion#GO:0007062;chromosome organization#GO:0051276 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cohesin complex#GO:0008278;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;chromosome#GO:0005694 HUMAN|HGNC=14887|UniProtKB=O75953 O75953 DNAJB5 PTHR24078:SF586 DNAJ HOMOLOG SUBFAMILY C MEMBER DNAJ HOMOLOG SUBFAMILY B MEMBER 5 binding#GO:0005488;protein-folding chaperone binding#GO:0051087;protein binding#GO:0005515 primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;protein folding#GO:0006457;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 chaperone#PC00072 HUMAN|HGNC=14358|UniProtKB=P78414 P78414 IRX1 PTHR11211:SF13 IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX-1 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;multicellular organism development#GO:0007275;developmental process#GO:0032502;neuron differentiation#GO:0030182;nervous system development#GO:0007399;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=20314|UniProtKB=Q86UA1 Q86UA1 PRPF39 PTHR17204:SF5 PRE-MRNA PROCESSING PROTEIN PRP39-RELATED PRE-MRNA-PROCESSING FACTOR 39 RNA binding#GO:0003723;binding#GO:0005488;pre-mRNA binding#GO:0036002;nucleic acid binding#GO:0003676 protein-RNA complex assembly#GO:0022618;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA splicing, via transesterification reactions#GO:0000375;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;macromolecule metabolic process#GO:0043170;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;spliceosomal complex assembly#GO:0000245;nucleic acid biosynthetic process#GO:0141187;ribonucleoprotein complex biogenesis#GO:0022613;mRNA cis splicing, via spliceosome#GO:0045292;mRNA metabolic process#GO:0016071;protein-containing complex assembly#GO:0065003;mRNA splicing, via spliceosome#GO:0000398;cellular component organization#GO:0016043;protein-containing complex organization#GO:0043933;protein-RNA complex organization#GO:0071826;cellular component organization or biogenesis#GO:0071840;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA processing#GO:0006396;mRNA splice site recognition#GO:0006376;gene expression#GO:0010467;cellular component assembly#GO:0022607;cellular process#GO:0009987;mRNA processing#GO:0006397;cellular component biogenesis#GO:0044085 organelle#GO:0043226;cellular anatomical structure#GO:0110165;U2-type prespliceosome#GO:0071004;intracellular membrane-bounded organelle#GO:0043231;U2-type spliceosomal complex#GO:0005684;spliceosomal complex#GO:0005681;spliceosomal snRNP complex#GO:0097525;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;U1 snRNP#GO:0005685;small nuclear ribonucleoprotein complex#GO:0030532;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;Sm-like protein family complex#GO:0120114 RNA metabolism protein#PC00031;RNA splicing factor#PC00148;RNA processing factor#PC00147 HUMAN|HGNC=3364|UniProtKB=Q9Y5L3 Q9Y5L3 ENTPD2 PTHR11782:SF33 ADENOSINE/GUANOSINE DIPHOSPHATASE ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 2 ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787;nucleoside diphosphate phosphatase activity#GO:0017110;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462 metabolic process#GO:0008152;nucleoside diphosphate metabolic process#GO:0009132;organophosphate catabolic process#GO:0046434;nucleobase-containing small molecule metabolic process#GO:0055086;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;nucleobase-containing compound catabolic process#GO:0034655;organophosphate metabolic process#GO:0019637;nucleoside diphosphate catabolic process#GO:0009134;cellular process#GO:0009987;nucleoside phosphate catabolic process#GO:1901292;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;nucleoside phosphate metabolic process#GO:0006753;nucleobase-containing compound metabolic process#GO:0006139 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 phosphatase#PC00181;hydrolase#PC00121;nucleotide phosphatase#PC00173 HUMAN|HGNC=30142|UniProtKB=Q99988 Q99988 GDF15 PTHR11848:SF78 TGF-BETA FAMILY GROWTH_DIFFERENTIATION FACTOR 15 signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;cytokine activity#GO:0005125;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545 cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;response to BMP#GO:0071772;cellular response to BMP stimulus#GO:0071773;cell surface receptor signaling pathway#GO:0007166;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;biological regulation#GO:0065007;signal transduction#GO:0007165;cellular process#GO:0009987;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;cellular response to growth factor stimulus#GO:0071363;response to stimulus#GO:0050896;response to growth factor#GO:0070848;cellular response to endogenous stimulus#GO:0071495;regulation of cellular process#GO:0050794;signaling#GO:0023052;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;BMP signaling pathway#GO:0030509;cellular response to stimulus#GO:0051716 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 growth factor#PC00112 TGF-beta signaling pathway#P00052>TGFbeta#P01286 HUMAN|HGNC=14821|UniProtKB=Q8NG75 Q8NG75 OR5T1 PTHR48018:SF194 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5T1-RELATED olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 multicellular organismal process#GO:0032501;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606;regulation of cellular process#GO:0050794;sensory perception of smell#GO:0007608;response to stimulus#GO:0050896;signaling#GO:0023052;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;nervous system process#GO:0050877;sensory perception#GO:0007600 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=10826|UniProtKB=Q9P0V3 Q9P0V3 SH3BP4 PTHR15603:SF3 SH3 DOMAIN-CONTAINING PROTEIN SH3 DOMAIN-BINDING PROTEIN 4 enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function regulator activity#GO:0098772 negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;regulation of intracellular signal transduction#GO:1902531;cellular response to chemical stimulus#GO:0070887;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;regulation of cellular process#GO:0050794;negative regulation of TOR signaling#GO:0032007;cellular response to amino acid stimulus#GO:0071230;response to stimulus#GO:0050896;regulation of cell communication#GO:0010646;negative regulation of biological process#GO:0048519;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;negative regulation of response to stimulus#GO:0048585;response to chemical#GO:0042221;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of TOR signaling#GO:0032006;cellular process#GO:0009987;response to acid chemical#GO:0001101 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=16038|UniProtKB=Q8N138 Q8N138 ORMDL3 PTHR12665:SF11 ORMDL PROTEINS ORM1-LIKE PROTEIN 3 lipid metabolic process#GO:0006629;chemical homeostasis#GO:0048878;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;ceramide metabolic process#GO:0006672;cellular process#GO:0009987;primary metabolic process#GO:0044238;lipid homeostasis#GO:0055088;homeostatic process#GO:0042592 transferase complex#GO:1990234;catalytic complex#GO:1902494;protein-containing complex#GO:0032991 HUMAN|HGNC=10616|UniProtKB=P55774 P55774 CCL18 PTHR12015:SF94 SMALL INDUCIBLE CYTOKINE A C-C MOTIF CHEMOKINE 18 signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;chemokine activity#GO:0008009;G protein-coupled receptor binding#GO:0001664;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;molecular function activator activity#GO:0140677;protein binding#GO:0005515;chemokine receptor binding#GO:0042379;cytokine activity#GO:0005125;cytokine receptor binding#GO:0005126;signaling receptor binding#GO:0005102;binding#GO:0005488 antimicrobial humoral response#GO:0019730;humoral immune response#GO:0006959;cell surface receptor signaling pathway#GO:0007166;granulocyte migration#GO:0097530;defense response to other organism#GO:0098542;response to cytokine#GO:0034097;taxis#GO:0042330;response to chemical#GO:0042221;response to stress#GO:0006950;response to chemokine#GO:1990868;response to biotic stimulus#GO:0009607;cellular process#GO:0009987;signal transduction#GO:0007165;defense response to symbiont#GO:0140546;positive regulation of biological process#GO:0048518;response to peptide#GO:1901652;immune system process#GO:0002376;G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887;granulocyte chemotaxis#GO:0071621;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052;positive regulation of cell motility#GO:2000147;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;defense response#GO:0006952;leukocyte chemotaxis#GO:0030595;positive regulation of locomotion#GO:0040017;response to external stimulus#GO:0009605;myeloid leukocyte migration#GO:0097529;leukocyte migration#GO:0050900;regulation of cell migration#GO:0030334;cell migration#GO:0016477;regulation of locomotion#GO:0040012;response to other organism#GO:0051707;biological regulation#GO:0065007;positive regulation of cell migration#GO:0030335;positive regulation of cellular process#GO:0048522;immune response#GO:0006955;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;chemokine-mediated signaling pathway#GO:0070098;regulation of cell motility#GO:2000145;cell communication#GO:0007154;cell chemotaxis#GO:0060326;cytokine-mediated signaling pathway#GO:0019221;chemotaxis#GO:0006935;inflammatory response#GO:0006954;cell motility#GO:0048870;regulation of cellular process#GO:0050794;locomotion#GO:0040011;cellular response to chemokine#GO:1990869;response to external biotic stimulus#GO:0043207;cellular response to stimulus#GO:0051716 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 cytokine#PC00083 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CHK#P00856 HUMAN|HGNC=7326|UniProtKB=P20585 P20585 MSH3 PTHR11361:SF158 DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER DNA MISMATCH REPAIR PROTEIN MSH3 nucleic acid binding#GO:0003676;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677 multicellular organism development#GO:0007275;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;DNA recombination#GO:0006310;gene expression#GO:0010467;response to stress#GO:0006950;somatic recombination of immunoglobulin gene segments#GO:0016447;cellular process#GO:0009987;immune system development#GO:0002520;immune system process#GO:0002376;animal gross anatomical part developmental process#GO:0160108;cellular response to stress#GO:0033554;somatic diversification of immune receptors via germline recombination within a single locus#GO:0002562;response to stimulus#GO:0050896;production of molecular mediator of immune response#GO:0002440;mismatch repair#GO:0006298;macromolecule metabolic process#GO:0043170;DNA repair#GO:0006281;DNA damage response#GO:0006974;developmental process#GO:0032502;multicellular organismal process#GO:0032501;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;somatic cell DNA recombination#GO:0016444;macromolecule biosynthetic process#GO:0009059;anatomical structure development#GO:0048856;system development#GO:0048731;mitotic recombination#GO:0006312;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;somatic diversification of immune receptors#GO:0002200;cellular response to stimulus#GO:0051716 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA metabolism protein#PC00009 HUMAN|HGNC=1577|UniProtKB=P78396 P78396 CCNA1 PTHR10177:SF254 CYCLINS CYCLIN-A1 enzyme regulator activity#GO:0030234;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;cyclin-dependent protein kinase regulator activity#GO:0019914;protein kinase regulator activity#GO:0019887;cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538 mitotic cell cycle process#GO:1903047;G1/S transition of mitotic cell cycle#GO:0000082;mitotic cell cycle phase transition#GO:0044772;cell cycle phase transition#GO:0044770;mitotic cell cycle#GO:0000278;cell cycle process#GO:0022402;cellular process#GO:0009987;cell cycle G1/S phase transition#GO:0044843;cell cycle#GO:0007049 microtubule cytoskeleton#GO:0015630;nucleus#GO:0005634;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;transferase complex#GO:1990234;membraneless organelle#GO:0043228;protein kinase complex#GO:1902911;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554 kinase activator#PC00138 p53 pathway feedback loops 2#P04398>cyclin A#P04666 HUMAN|HGNC=30059|UniProtKB=Q643R3 Q643R3 LPCAT4 PTHR23063:SF7 PHOSPHOLIPID ACYLTRANSFERASE LYSOPHOSPHOLIPID ACYLTRANSFERASE LPCAT4 transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 transferase#PC00220;acyltransferase#PC00042;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=6610|UniProtKB=P55344 P55344 LIM2 PTHR10671:SF9 EPITHELIAL MEMBRANE PROTEIN-RELATED LENS FIBER MEMBRANE INTRINSIC PROTEIN cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 cytoskeletal protein#PC00085 HUMAN|HGNC=20996|UniProtKB=Q9NVP2 Q9NVP2 ASF1B PTHR12040:SF22 ANTI-SILENCING PROTEIN 1 HISTONE CHAPERONE ASF1B protein binding#GO:0005515;binding#GO:0005488;histone binding#GO:0042393 cellular process#GO:0009987;cellular component organization#GO:0016043;chromatin organization#GO:0006325;cellular component organization or biogenesis#GO:0071840 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=11000|UniProtKB=Q9Y2P4 Q9Y2P4 SLC27A6 PTHR43107:SF10 LONG-CHAIN FATTY ACID TRANSPORT PROTEIN LONG-CHAIN FATTY ACID TRANSPORT PROTEIN 6 ATP-dependent activity#GO:0140657;carboxylic acid transmembrane transporter activity#GO:0046943;ligase activity, forming carbon-sulfur bonds#GO:0016877;transmembrane transporter activity#GO:0022857;ligase activity#GO:0016874;transporter activity#GO:0005215;catalytic activity#GO:0003824;monocarboxylic acid transmembrane transporter activity#GO:0008028 lipid transport#GO:0006869;macromolecule localization#GO:0033036;long-chain fatty acid metabolic process#GO:0001676;cellular process#GO:0009987;establishment of localization#GO:0051234;import into cell#GO:0098657;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;lipid metabolic process#GO:0006629;transport#GO:0006810;organic acid transport#GO:0015849;carboxylic acid transport#GO:0046942;small molecule metabolic process#GO:0044281;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;localization#GO:0051179;fatty acid transport#GO:0015908;monocarboxylic acid transport#GO:0015718;lipid localization#GO:0010876;oxoacid metabolic process#GO:0043436 organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;plasma membrane#GO:0005886;cytoplasm#GO:0005737;membrane#GO:0016020;cell periphery#GO:0071944;organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783 secondary carrier transporter#PC00258 HUMAN|HGNC=6716|UniProtKB=Q9NS15 Q9NS15 LTBP3 PTHR24034:SF46 EGF-LIKE DOMAIN-CONTAINING PROTEIN LATENT-TRANSFORMING GROWTH FACTOR BETA-BINDING PROTEIN 3 response to stimulus#GO:0050896;response to growth factor#GO:0070848;cellular response to endogenous stimulus#GO:0071495;regulation of cellular process#GO:0050794;signaling#GO:0023052;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;cellular response to transforming growth factor beta stimulus#GO:0071560;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;cellular response to growth factor stimulus#GO:0071363;response to transforming growth factor beta#GO:0071559;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;biological regulation#GO:0065007;transforming growth factor beta receptor signaling pathway#GO:0007179;signal transduction#GO:0007165;cellular process#GO:0009987;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;cell surface receptor signaling pathway#GO:0007166 extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical structure#GO:0110165 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HUMAN|HGNC=8488|UniProtKB=Q13416 Q13416 ORC2 PTHR14052:SF0 ORIGIN RECOGNITION COMPLEX SUBUNIT 2 ORIGIN RECOGNITION COMPLEX SUBUNIT 2 sequence-specific DNA binding#GO:0043565;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;sequence-specific double-stranded DNA binding#GO:1990837;binding#GO:0005488;DNA replication origin binding#GO:0003688;nucleic acid binding#GO:0003676 macromolecule metabolic process#GO:0043170;DNA-templated DNA replication#GO:0006261;DNA replication initiation#GO:0006270;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;DNA replication#GO:0006260;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 nucleus#GO:0005634;chromatin#GO:0000785;membrane-enclosed lumen#GO:0031974;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nuclear origin of replication recognition complex#GO:0005664;membraneless organelle#GO:0043228;heterochromatin#GO:0000792;origin recognition complex#GO:0000808;nuclear protein-containing complex#GO:0140513;organelle lumen#GO:0043233;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 replication origin binding protein#PC00199 HUMAN|HGNC=19245|UniProtKB=Q96RF0 Q96RF0 SNX18 PTHR45827:SF4 SORTING NEXIN SORTING NEXIN-18 ion binding#GO:0043167;anion binding#GO:0043168;binding#GO:0005488;phosphatidylinositol binding#GO:0035091;small molecule binding#GO:0036094 intracellular transport#GO:0046907;transport#GO:0006810;membrane invagination#GO:0010324;establishment of localization#GO:0051234;import into cell#GO:0098657;cellular component organization or biogenesis#GO:0071840;endosomal transport#GO:0016197;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;membrane organization#GO:0061024;endomembrane system organization#GO:0010256;cytokinesis#GO:0000910;cytokinetic process#GO:0032506;cellular localization#GO:0051641;plasma membrane organization#GO:0007009;cytoskeleton-dependent cytokinesis#GO:0061640;localization#GO:0051179;cellular component organization#GO:0016043;cell cycle#GO:0007049;cell division#GO:0051301;cell cycle process#GO:0022402;endocytosis#GO:0006897 plasma membrane#GO:0005886;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;cell periphery#GO:0071944;intracellular vesicle#GO:0097708;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 scaffold/adaptor protein#PC00226 HUMAN|HGNC=412|UniProtKB=P49189 P49189 ALDH9A1 PTHR11699:SF228 ALDEHYDE DEHYDROGENASE-RELATED 4-TRIMETHYLAMINOBUTYRALDEHYDE DEHYDROGENASE catalytic activity#GO:0003824;oxidoreductase activity, acting on the aldehyde or oxo group of donors#GO:0016903;aldehyde dehydrogenase (NAD+) activity#GO:0004029;oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor#GO:0016620;oxidoreductase activity#GO:0016491 biosynthetic process#GO:0009058;modified amino acid metabolic process#GO:0006575;metabolic process#GO:0008152;cellular process#GO:0009987;carnitine metabolic process#GO:0009437 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 metabolite interconversion enzyme#PC00262;dehydrogenase#PC00092 5-Hydroxytryptamine degredation#P04372>Aldehyde Dehydrogenase#P04402 HUMAN|HGNC=33783|UniProtKB=A6NFD8 A6NFD8 HELT PTHR10985:SF8 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED HAIRY AND ENHANCER OF SPLIT-RELATED PROTEIN HELT transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 negative regulation of macromolecule biosynthetic process#GO:0010558;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of multicellular organismal process#GO:0051239;anterior/posterior pattern specification#GO:0009952;cell surface receptor signaling pathway#GO:0007166;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;multicellular organism development#GO:0007275;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of multicellular organismal development#GO:2000026;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;signaling#GO:0023052;negative regulation of metabolic process#GO:0009892;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;regulation of cell development#GO:0060284;regulation of nucleobase-containing compound metabolic process#GO:0019219;regionalization#GO:0003002;multicellular organismal process#GO:0032501;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;regulation of cell differentiation#GO:0045595;Notch signaling pathway#GO:0007219;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of neurogenesis#GO:0050767;cellular response to stimulus#GO:0051716;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of developmental process#GO:0050793;pattern specification process#GO:0007389;cell communication#GO:0007154;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of nervous system development#GO:0051960;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 basic helix-loop-helix transcription factor#PC00055 Notch signaling pathway#P00045>E(spl)-C genes#G01541 HUMAN|HGNC=18021|UniProtKB=Q7Z403 Q7Z403 TMC6 PTHR23302:SF4 TRANSMEMBRANE CHANNEL-RELATED TRANSMEMBRANE CHANNEL-LIKE PROTEIN 6 channel activity#GO:0015267;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;gated channel activity#GO:0022836;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;passive transmembrane transporter activity#GO:0022803 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 ion channel#PC00133 HUMAN|HGNC=16869|UniProtKB=Q7L311 Q7L311 ARMCX2 PTHR15712:SF9 ARMADILLO REPEAT CONTAINING PROTEIN ARMADILLO REPEAT-CONTAINING X-LINKED PROTEIN 2 cellular localization#GO:0051641;localization#GO:0051179;microtubule-based transport#GO:0099111;organelle localization#GO:0051640;axonal transport#GO:0098930;microtubule-based movement#GO:0007018;establishment of organelle localization#GO:0051656;mitochondrion localization#GO:0051646;microtubule-based process#GO:0007017;transport along microtubule#GO:0010970;establishment of localization#GO:0051234;transport#GO:0006810;intracellular transport#GO:0046907;organelle transport along microtubule#GO:0072384;cytoskeleton-dependent intracellular transport#GO:0030705;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;axo-dendritic transport#GO:0008088 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 scaffold/adaptor protein#PC00226 HUMAN|HGNC=32325|UniProtKB=Q5VTH2 Q5VTH2 CFAP126 PTHR34639:SF1 PROTEIN FLATTOP PROTEIN FLATTOP organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;cell projection organization#GO:0030030;cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782;plasma membrane bounded cell projection organization#GO:0120036 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;microtubule organizing center#GO:0005815;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;cilium#GO:0005929;intracellular organelle#GO:0043229 HUMAN|HGNC=15945|UniProtKB=P08861 P08861 CELA3B PTHR24257:SF22 CHYMOTRYPSIN-LIKE ELASTASE FAMILY MEMBER CHYMOTRYPSIN-LIKE ELASTASE FAMILY MEMBER 3B serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;serine-type peptidase activity#GO:0008236;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;catalytic activity#GO:0003824 primary metabolic process#GO:0044238;proteolysis#GO:0006508;metabolic process#GO:0008152;cellular process#GO:0009987;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;serine protease#PC00203;protease#PC00190 HUMAN|HGNC=11823|UniProtKB=Q99727 Q99727 TIMP4 PTHR11844:SF26 METALLOPROTEASE INHIBITOR METALLOPROTEINASE INHIBITOR 4 enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;peptidase regulator activity#GO:0061134;endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772;enzyme inhibitor activity#GO:0004857 negative regulation of catabolic process#GO:0009895;regulation of protein catabolic process#GO:0042176;response to peptide#GO:1901652;response to endogenous stimulus#GO:0009719;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;negative regulation of cellular process#GO:0048523;regulation of proteolysis#GO:0030162;regulation of catabolic process#GO:0009894;regulation of primary metabolic process#GO:0080090;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;response to hormone#GO:0009725;negative regulation of macromolecule metabolic process#GO:0010605;response to chemical#GO:0042221;response to cytokine#GO:0034097;negative regulation of protein catabolic process#GO:0042177;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 protein-binding activity modulator#PC00095;protease inhibitor#PC00191 HUMAN|HGNC=38708|UniProtKB=C9JBD0 C9JBD0 KRABD1 PTHR23232:SF139 KRAB DOMAIN C2H2 ZINC FINGER KRAB DOMAIN-CONTAINING PROTEIN 1 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=691|UniProtKB=O14813 O14813 PHOX2A PTHR24329:SF303 HOMEOBOX PROTEIN ARISTALESS PAIRED MESODERM HOMEOBOX PROTEIN 2A transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;nervous system development#GO:0007399;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;multicellular organism development#GO:0007275;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;developmental process#GO:0032502;neuron differentiation#GO:0030182;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;cell development#GO:0048468;regulation of biological process#GO:0050789;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;neuron development#GO:0048666;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=25515|UniProtKB=Q8TEP8 Q8TEP8 CEP192 PTHR16029:SF11 CENTROSOMAL PROTEIN OF 192 KDA CENTROSOMAL PROTEIN OF 192 KDA chromosome segregation#GO:0007059;microtubule organizing center organization#GO:0031023;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;spindle assembly#GO:0051225;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;nuclear division#GO:0000280;protein localization to microtubule organizing center#GO:1905508;centrosome cycle#GO:0007098;mitotic nuclear division#GO:0140014;cell cycle process#GO:0022402;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;nuclear chromosome segregation#GO:0098813;sister chromatid segregation#GO:0000819;protein localization to cytoskeleton#GO:0044380;mitotic spindle organization#GO:0007052;mitotic cell cycle process#GO:1903047;intracellular protein localization#GO:0008104;chromosome organization#GO:0051276;spindle organization#GO:0007051;mitotic spindle assembly#GO:0090307;macromolecule localization#GO:0033036;mitotic sister chromatid segregation#GO:0000070;protein localization to microtubule cytoskeleton#GO:0072698;organelle assembly#GO:0070925;localization#GO:0051179;organelle fission#GO:0048285;microtubule cytoskeleton organization#GO:0000226;protein localization to centrosome#GO:0071539;cell cycle#GO:0007049;microtubule cytoskeleton organization involved in mitosis#GO:1902850;mitotic cell cycle#GO:0000278;protein localization to organelle#GO:0033365 microtubule cytoskeleton#GO:0015630;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;centriole#GO:0005814;cytoplasm#GO:0005737;centrosome#GO:0005813;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=8100|UniProtKB=Q02509 Q02509 OC90 PTHR11716:SF1 PHOSPHOLIPASE A2 FAMILY MEMBER OTOCONIN-90 hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;phospholipid binding#GO:0005543;carboxylic ester hydrolase activity#GO:0052689;lipase activity#GO:0016298;small molecule binding#GO:0036094;ion binding#GO:0043167;cation binding#GO:0043169;hydrolase activity#GO:0016787;phospholipase activity#GO:0120569;glycerophospholipase activity#GO:0004620;A2-type glycerophospholipase activity#GO:0004623;calcium ion binding#GO:0005509;binding#GO:0005488;lipid binding#GO:0008289;metal ion binding#GO:0046872 organophosphate metabolic process#GO:0019637;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;cellular process#GO:0009987;phosphatidylglycerol metabolic process#GO:0046471;glycerolipid metabolic process#GO:0046486;phosphatidylcholine metabolic process#GO:0046470;glycerophospholipid metabolic process#GO:0006650;phospholipid metabolic process#GO:0006644;metabolic process#GO:0008152;lipid metabolic process#GO:0006629 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 phospholipase#PC00186 HUMAN|HGNC=18264|UniProtKB=Q8NEY4 Q8NEY4 ATP6V1C2 PTHR10137:SF4 V-TYPE PROTON ATPASE SUBUNIT C V-TYPE PROTON ATPASE SUBUNIT C 2 monoatomic cation transmembrane transporter activity#GO:0008324;ATPase-coupled transmembrane transporter activity#GO:0042626;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATP-dependent activity#GO:0140657;monoatomic ion transmembrane transporter activity#GO:0015075;active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399;proton transmembrane transporter activity#GO:0015078;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 membrane protein complex#GO:0098796;cation-transporting ATPase complex#GO:0090533;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vacuolar proton-transporting V-type ATPase, V1 domain#GO:0000221;intracellular membrane-bounded organelle#GO:0043231;ATPase complex#GO:1904949;vacuolar proton-transporting V-type ATPase complex#GO:0016471;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transmembrane transporter complex#GO:1902495;ATPase dependent transmembrane transport complex#GO:0098533;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;vacuole#GO:0005773;proton-transporting two-sector ATPase complex#GO:0016469;vacuolar membrane#GO:0005774;transporter complex#GO:1990351;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;proton-transporting V-type ATPase complex#GO:0033176 ATP synthase#PC00002 HUMAN|HGNC=16083|UniProtKB=Q9NX52 Q9NX52 RHBDL2 PTHR45840:SF6 RHOMBOID-RELATED PROTEIN RHOMBOID-RELATED PROTEIN 2 catalytic activity#GO:0003824;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171 HUMAN|HGNC=5997|UniProtKB=Q9NP60 Q9NP60 IL1RAPL2 PTHR11890:SF10 INTERLEUKIN-1 RECEPTOR FAMILY MEMBER X-LINKED INTERLEUKIN-1 RECEPTOR ACCESSORY PROTEIN-LIKE 2 signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=4600|UniProtKB=O00222 O00222 GRM8 PTHR24060:SF26 METABOTROPIC GLUTAMATE RECEPTOR METABOTROPIC GLUTAMATE RECEPTOR 8 molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;adenylate cyclase inhibiting G protein-coupled glutamate receptor activity#GO:0001640;glutamate receptor activity#GO:0008066;transmembrane signaling receptor activity#GO:0004888 G protein-coupled receptor signaling pathway#GO:0007186;regulation of signaling#GO:0023051;cell communication#GO:0007154;regulation of synaptic transmission, glutamatergic#GO:0051966;glutamate receptor signaling pathway#GO:0007215;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of cell communication#GO:0010646;signaling#GO:0023052;modulation of chemical synaptic transmission#GO:0050804;cell surface receptor signaling pathway#GO:0007166;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of trans-synaptic signaling#GO:0099177;biological regulation#GO:0065007 G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GqPCR#P00730;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;Metabotropic glutamate receptor group III pathway#P00039>mGluR4/6/7/8#P01044;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GoPCR#P00725 HUMAN|HGNC=30447|UniProtKB=Q8N2A8 Q8N2A8 PLD6 PTHR43856:SF3 CARDIOLIPIN HYDROLASE MITOCHONDRIAL CARDIOLIPIN HYDROLASE phosphoric ester hydrolase activity#GO:0042578;phosphoric diester hydrolase activity#GO:0008081;catalytic activity, acting on RNA#GO:0140098;RNA endonuclease activity#GO:0004521;endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;catalytic activity#GO:0003824;glycerophospholipase activity#GO:0004620;catalytic activity, acting on a nucleic acid#GO:0140640;phospholipase activity#GO:0120569;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;nuclease activity#GO:0004518;lipase activity#GO:0016298 cellular process involved in reproduction in multicellular organism#GO:0022412;cell development#GO:0048468;negative regulation of metabolic process#GO:0009892;gamete generation#GO:0007276;cell differentiation#GO:0030154;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;oogenesis#GO:0048477;RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleobase-containing compound biosynthetic process#GO:0034654;meiotic cell cycle#GO:0051321;metabolic process#GO:0008152;reproductive process#GO:0022414;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;germ cell development#GO:0007281;primary metabolic process#GO:0044238;developmental process involved in reproduction#GO:0003006;nucleic acid metabolic process#GO:0090304;cell cycle#GO:0007049;multicellular organismal reproductive process#GO:0048609;anatomical structure development#GO:0048856;sexual reproduction#GO:0019953;piRNA processing#GO:0034587;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;macromolecule biosynthetic process#GO:0009059;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulatory ncRNA processing#GO:0070918;macromolecule metabolic process#GO:0043170;developmental process#GO:0032502;regulatory ncRNA-mediated gene silencing#GO:0031047;negative regulation of cellular process#GO:0048523 mitochondrial outer membrane#GO:0005741;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;organelle outer membrane#GO:0031968;cytoplasm#GO:0005737;membrane#GO:0016020;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;outer membrane#GO:0019867;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;mitochondrion#GO:0005739 phospholipase#PC00186 HUMAN|HGNC=34294|UniProtKB=A6NGD5 A6NGD5 ZSCAN5C PTHR23226:SF151 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 5C transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=23251|UniProtKB=Q6E213 Q6E213 AWAT2 PTHR12317:SF12 DIACYLGLYCEROL O-ACYLTRANSFERASE ACYL-COA WAX ALCOHOL ACYLTRANSFERASE 2 transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 lipid biosynthetic process#GO:0008610;glycerolipid metabolic process#GO:0046486;triglyceride biosynthetic process#GO:0019432;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;neutral lipid metabolic process#GO:0006638;acylglycerol metabolic process#GO:0006639;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;triglyceride metabolic process#GO:0006641 intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum membrane#GO:0005789;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane#GO:0016020 transferase#PC00220;acyltransferase#PC00042 HUMAN|HGNC=175|UniProtKB=P37023 P37023 ACVRL1 PTHR23255:SF66 TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II ACTIVIN RECEPTOR TYPE-1-LIKE kinase activity#GO:0016301;transforming growth factor beta receptor activity#GO:0005024;transferase activity#GO:0016740;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;transmembrane receptor protein serine/threonine kinase activity#GO:0004675;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein binding#GO:0005515;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity, acting on a protein#GO:0140096;molecular transducer activity#GO:0060089 regulation of cellular process#GO:0050794;response to growth factor#GO:0070848;blood vessel development#GO:0001568;tube morphogenesis#GO:0035239;cellular response to transforming growth factor beta stimulus#GO:0071560;BMP signaling pathway#GO:0030509;cellular response to stimulus#GO:0051716;dorsal/ventral pattern formation#GO:0009953;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;system development#GO:0048731;response to transforming growth factor beta#GO:0071559;pattern specification process#GO:0007389;multicellular organismal process#GO:0032501;regionalization#GO:0003002;tube development#GO:0035295;biological regulation#GO:0065007;cellular developmental process#GO:0048869;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;developmental process#GO:0032502;response to BMP#GO:0071772;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;circulatory system development#GO:0072359;cell differentiation#GO:0030154;signaling#GO:0023052;blood vessel morphogenesis#GO:0048514;response to endogenous stimulus#GO:0009719;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;angiogenesis#GO:0001525;cellular response to growth factor stimulus#GO:0071363;animal gross anatomical part developmental process#GO:0160108;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;heart development#GO:0007507;transforming growth factor beta receptor signaling pathway#GO:0007179;cellular process#GO:0009987;signal transduction#GO:0007165;animal organ development#GO:0048513;multicellular organism development#GO:0007275;vasculature development#GO:0001944;anatomical structure formation involved in morphogenesis#GO:0048646;cell surface receptor signaling pathway#GO:0007166;cellular response to BMP stimulus#GO:0071773 cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;signaling receptor complex#GO:0043235 serine/threonine protein kinase receptor#PC00205 TGF-beta signaling pathway#P00052>TGFbetareceptors#P01283;TGF-beta signaling pathway#P00052>TGFbetareceptor I#P01278 HUMAN|HGNC=30531|UniProtKB=Q96A22 Q96A22 C11orf52 PTHR37342:SF1 HYPOTHETICAL PROTEIN LOC689959 CHROMOSOME 11 OPEN READING FRAME 52 HUMAN|HGNC=31837|UniProtKB=Q8N5X7 Q8N5X7 EIF4E3 PTHR11960:SF66 EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TYPE 3 translation factor activity#GO:0180051;nucleic acid binding#GO:0003676;binding#GO:0005488;translation initiation factor activity#GO:0003743;RNA binding#GO:0003723 primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058;metabolic process#GO:0008152;translation#GO:0006412;translational initiation#GO:0006413;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 HUMAN|HGNC=23324|UniProtKB=Q3SY17 Q3SY17 SLC25A52 PTHR46131:SF2 SD08549P MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER SLC25A51-RELATED nucleobase-containing compound transmembrane transporter activity#GO:0015932;organophosphate ester transmembrane transporter activity#GO:0015605;purine nucleotide transmembrane transporter activity#GO:0015216;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 nucleobase-containing compound transport#GO:0015931;organophosphate ester transport#GO:0015748;nitrogen compound transport#GO:0071705;cellular process#GO:0009987;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739 HUMAN|HGNC=29096|UniProtKB=Q17R89 Q17R89 ARHGAP44 PTHR14130:SF13 3BP-1 RELATED RHOGAP RHO GTPASE-ACTIVATING PROTEIN 44 molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;enzyme activator activity#GO:0008047 regulation of postsynapse organization#GO:0099175;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of cell communication#GO:0010646;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;regulation of signaling#GO:0023051;regulation of synapse organization#GO:0050807;regulation of dendritic spine morphogenesis#GO:0061001;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648;regulation of biological quality#GO:0065008;regulation of synapse structure or activity#GO:0050803;negative regulation of intracellular signal transduction#GO:1902532;regulation of neuron projection development#GO:0010975;regulation of actin cytoskeleton organization#GO:0032956;negative regulation of signal transduction#GO:0009968;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of response to stimulus#GO:0048585;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;regulation of actin filament-based process#GO:0032970;regulation of cell projection organization#GO:0031344;regulation of small GTPase mediated signal transduction#GO:0051056;regulation of anatomical structure morphogenesis#GO:0022603;regulation of plasma membrane bounded cell projection organization#GO:0120035 membrane#GO:0016020;cell leading edge#GO:0031252;cell periphery#GO:0071944;presynapse#GO:0098793;neuron projection#GO:0043005;neuron to neuron synapse#GO:0098984;postsynaptic specialization#GO:0099572;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;presynaptic active zone#GO:0048786;cell junction#GO:0030054;postsynapse#GO:0098794;dendritic spine#GO:0043197;synapse#GO:0045202;cellular anatomical structure#GO:0110165;asymmetric synapse#GO:0032279;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;neuron spine#GO:0044309;cell projection#GO:0042995;dendrite#GO:0030425;postsynaptic density#GO:0014069;leading edge membrane#GO:0031256;dendritic tree#GO:0097447 GTPase-activating protein#PC00257 HUMAN|HGNC=55|UniProtKB=O15439 O15439 ABCC4 PTHR24223:SF357 ATP-BINDING CASSETTE SUB-FAMILY C ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 4 transport#GO:0006810;cellular process#GO:0009987;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234 plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;basal part of cell#GO:0045178;basolateral plasma membrane#GO:0016323;membrane#GO:0016020;basal plasma membrane#GO:0009925;cell periphery#GO:0071944 ATP-binding cassette (ABC) transporter#PC00003 HUMAN|HGNC=28741|UniProtKB=Q86SU0 Q86SU0 ILDR1 PTHR15923:SF3 TRANSMEMBRANE AND IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN IMMUNOGLOBULIN-LIKE DOMAIN-CONTAINING RECEPTOR 1 cargo receptor activity#GO:0038024 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=18066|UniProtKB=P59095 P59095 STARD6 PTHR46374:SF2 PROTEIN CBG07384 STAR-RELATED LIPID TRANSFER PROTEIN 6 HUMAN|HGNC=2289|UniProtKB=O14548 O14548 COX7A2L PTHR10510:SF2 CYTOCHROME C OXIDASE POLYPEPTIDE 7A CYTOCHROME C OXIDASE SUBUNIT 7A2-LIKE, MITOCHONDRIAL molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 energy derivation by oxidation of organic compounds#GO:0015980;cellular respiration#GO:0045333;oxidative phosphorylation#GO:0006119;aerobic respiration#GO:0009060;metabolic process#GO:0008152;cellular process#GO:0009987;generation of precursor metabolites and energy#GO:0006091 organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle envelope#GO:0031967;membrane#GO:0016020;mitochondrion#GO:0005739;respiratory chain complex#GO:0098803;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 oxidoreductase#PC00176;oxidase#PC00175 HUMAN|HGNC=6469|UniProtKB=Q16719 Q16719 KYNU PTHR14084:SF0 KYNURENINASE KYNURENINASE hydrolase activity#GO:0016787;catalytic activity#GO:0003824 metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;proteinogenic amino acid metabolic process#GO:0170039;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;amino acid metabolic process#GO:0006520;small molecule catabolic process#GO:0044282;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;cellular process#GO:0009987;indole-containing compound metabolic process#GO:0042430;carboxylic acid catabolic process#GO:0046395 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HUMAN|HGNC=30634|UniProtKB=Q12770 Q12770 SCAP PTHR46378:SF1 STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN regulation of biosynthetic process#GO:0009889;regulation of primary metabolic process#GO:0080090;response to stress#GO:0006950;regulation of metabolic process#GO:0019222;signal transduction#GO:0007165;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of lipid biosynthetic process#GO:0046890;regulation of steroid biosynthetic process#GO:0050810;biological regulation#GO:0065007;SREBP signaling pathway#GO:0032933;regulation of lipid metabolic process#GO:0019216;cellular response to stress#GO:0033554;cell communication#GO:0007154;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;intracellular signal transduction#GO:0035556;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052 organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;membrane protein complex#GO:0098796;organelle membrane#GO:0031090;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;cytoplasm#GO:0005737;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;membrane#GO:0016020 HUMAN|HGNC=9186|UniProtKB=O75417 O75417 POLQ PTHR10133:SF64 DNA POLYMERASE I DNA POLYMERASE THETA DNA-directed DNA polymerase activity#GO:0003887;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772;DNA polymerase activity#GO:0034061;catalytic activity, acting on DNA#GO:0140097 macromolecule metabolic process#GO:0043170;double-strand break repair via nonhomologous end joining#GO:0006303;double-strand break repair#GO:0006302;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;primary metabolic process#GO:0044238;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 DNA-directed DNA polymerase#PC00018 HUMAN|HGNC=10973|UniProtKB=Q9UGH3 Q9UGH3 SLC23A2 PTHR11119:SF33 XANTHINE-URACIL / VITAMIN C PERMEASE FAMILY MEMBER SOLUTE CARRIER FAMILY 23 MEMBER 2 secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;solute:monoatomic cation symporter activity#GO:0015294;sugar transmembrane transporter activity#GO:0051119;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;symporter activity#GO:0015293;carboxylic acid transmembrane transporter activity#GO:0046943;solute:sodium symporter activity#GO:0015370;monoatomic cation transmembrane transporter activity#GO:0008324;carbohydrate transmembrane transporter activity#GO:0015144 cellular process#GO:0009987;carbohydrate transmembrane transport#GO:0034219;vitamin transport#GO:0051180;carboxylic acid transmembrane transport#GO:1905039;carboxylic acid transport#GO:0046942;organic acid transport#GO:0015849;transport#GO:0006810;carbohydrate transport#GO:0008643;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179 apical part of cell#GO:0045177;cell periphery#GO:0071944;apical plasma membrane#GO:0016324;membrane#GO:0016020;plasma membrane#GO:0005886;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165 transporter#PC00227 HUMAN|HGNC=29808|UniProtKB=Q9BYE2 Q9BYE2 TMPRSS13 PTHR24253:SF55 TRANSMEMBRANE PROTEASE SERINE TRANSMEMBRANE PROTEASE SERINE 13 serine-type peptidase activity#GO:0008236;catalytic activity#GO:0003824;peptidase activity#GO:0008233;serine hydrolase activity#GO:0017171;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;protein processing#GO:0016485;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;proteolysis#GO:0006508;metabolic process#GO:0008152 protein modifying enzyme#PC00260;serine protease#PC00203;protease#PC00190 HUMAN|HGNC=12488|UniProtKB=P68036 P68036 UBE2L3 PTHR24068:SF67 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2 L3 acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein conjugating enzyme activity#GO:0061650;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin conjugating enzyme activity#GO:0061631;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 catabolic process#GO:0009056;protein K11-linked ubiquitination#GO:0070979;primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein polyubiquitination#GO:0000209;modification-dependent protein catabolic process#GO:0019941;protein modification by small protein conjugation#GO:0032446;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein modification by small protein conjugation or removal#GO:0070647;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057 ubiquitin-protein ligase#PC00234 Ubiquitin proteasome pathway#P00060>E2#P01491;Parkinson disease#P00049>UbcH7#P01224 HUMAN|HGNC=14350|UniProtKB=Q8IVW6 Q8IVW6 ARID3B PTHR15348:SF3 AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN ARID DOMAIN- CONTAINING PROTEIN DEAD RINGER PROTEIN B-CELL REGULATOR OF IGH TRANSCRIPTION BRIGHT AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 3B nucleic acid binding#GO:0003676;binding#GO:0005488;DNA binding#GO:0003677 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HUMAN|HGNC=3185|UniProtKB=Q15075 Q15075 EEA1 PTHR23164:SF30 EARLY ENDOSOME ANTIGEN 1 EARLY ENDOSOME ANTIGEN 1 lipid binding#GO:0008289;binding#GO:0005488;phospholipid binding#GO:0005543 endocytosis#GO:0006897;import into cell#GO:0098657;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810 endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;intracellular vesicle#GO:0097708;vesicle#GO:0031982;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 membrane traffic protein#PC00150;membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=10074|UniProtKB=P13489 P13489 RNH1 PTHR24112:SF50 LEUCINE-RICH REPEAT, ISOFORM F-RELATED RIBONUCLEASE INHIBITOR enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;molecular function inhibitor activity#GO:0140678;enzyme inhibitor activity#GO:0004857 cellular process#GO:0009987;regulation of actin filament organization#GO:0110053;cell migration#GO:0016477;regulation of multicellular organismal process#GO:0051239;regulation of actin cytoskeleton organization#GO:0032956;biological regulation#GO:0065007;regulation of vasculature development#GO:1901342;regulation of actin filament-based process#GO:0032970;regulation of actin nucleation#GO:0051125;regulation of anatomical structure morphogenesis#GO:0022603;regulation of multicellular organismal development#GO:2000026;regulation of organelle organization#GO:0033043;regulation of supramolecular fiber organization#GO:1902903;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;cell motility#GO:0048870;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;regulation of developmental process#GO:0050793;regulation of angiogenesis#GO:0045765 plasma membrane#GO:0005886;lamellipodium#GO:0030027;protein-containing complex#GO:0032991;cell periphery#GO:0071944;nucleus#GO:0005634;cell leading edge#GO:0031252;membrane#GO:0016020;membrane-enclosed lumen#GO:0031974;extracellular protein-containing complex#GO:0140392;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;extracellular region#GO:0005576;intracellular organelle lumen#GO:0070013 protein-binding activity modulator#PC00095 HUMAN|HGNC=4984|UniProtKB=P05114 P05114 HMGN1 PTHR23087:SF12 NONHISTONE CHROMOSOMAL PROTEIN HMG NON-HISTONE CHROMOSOMAL PROTEIN HMG-14 chromatin binding#GO:0003682;binding#GO:0005488 cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;chromatin organization#GO:0006325 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=21658|UniProtKB=Q8NEE6 Q8NEE6 FBXL13 PTHR13318:SF275 PARTNER OF PAIRED, ISOFORM B-RELATED F-BOX AND LEUCINE-RICH REPEAT PROTEIN 13 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987 cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535;SCF ubiquitin ligase complex#GO:0019005;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;transferase complex#GO:1990234;catalytic complex#GO:1902494 HUMAN|HGNC=23279|UniProtKB=A2CJ06 A2CJ06 DYTN PTHR12268:SF18 E3 UBIQUITIN-PROTEIN LIGASE KCMF1 DYSTROTELIN plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane protein complex#GO:0098796;dystrophin-associated glycoprotein complex#GO:0016010;membrane#GO:0016020;cell projection#GO:0042995;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=31124|UniProtKB=P58550 P58550 FXYD6P3 PTHR14132:SF15 SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT GAMMA FXYD DOMAIN-CONTAINING ION TRANSPORT REGULATOR 6-RELATED ion channel regulator activity#GO:0099106;transporter regulator activity#GO:0141108;channel regulator activity#GO:0016247;molecular function regulator activity#GO:0098772 biological regulation#GO:0065007;regulation of metal ion transport#GO:0010959;regulation of monoatomic ion transport#GO:0043269;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;positive regulation of cellular process#GO:0048522;positive regulation of transport#GO:0051050;positive regulation of biological process#GO:0048518;regulation of monoatomic ion transmembrane transport#GO:0034765;regulation of transmembrane transport#GO:0034762;regulation of transport#GO:0051049;regulation of localization#GO:0032879;regulation of monoatomic cation transmembrane transport#GO:1904062 primary active transporter#PC00068;transporter#PC00227 HUMAN|HGNC=14661|UniProtKB=Q9H6Z9 Q9H6Z9 EGLN3 PTHR12907:SF28 EGL NINE HOMOLOG-RELATED PROLYL HYDROXYLASE EGLN3 ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;transition metal ion binding#GO:0046914;dioxygenase activity#GO:0051213;metal ion binding#GO:0046872;cation binding#GO:0043169;ferrous iron binding#GO:0008198;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;oxidoreductase activity#GO:0016491;iron ion binding#GO:0005506;catalytic activity, acting on a protein#GO:0140096 biological regulation#GO:0065007;response to chemical#GO:0042221;cellular process#GO:0009987;response to stress#GO:0006950;regulation of neuron apoptotic process#GO:0043523;response to hypoxia#GO:0001666;regulation of apoptotic process#GO:0042981;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;response to abiotic stimulus#GO:0009628;cellular response to hypoxia#GO:0071456;response to decreased oxygen levels#GO:0036293;regulation of programmed cell death#GO:0043067;response to oxygen levels#GO:0070482;cellular response to stress#GO:0033554;cellular response to chemical stimulus#GO:0070887 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 Hypoxia response via HIF activation#P00030>Prolyl Hydroxylase#P00821 HUMAN|HGNC=6480|UniProtKB=P00709 P00709 LALBA PTHR11407:SF32 LYSOZYME C ALPHA-LACTALBUMIN hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824;peptidoglycan muralytic activity#GO:0061783;lysozyme activity#GO:0003796;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787 glycosidase#PC00110 HUMAN|HGNC=13944|UniProtKB=Q99944 Q99944 EGFL8 PTHR14949:SF27 EGF-LIKE-DOMAIN, MULTIPLE 7, 8 EPIDERMAL GROWTH FACTOR-LIKE PROTEIN 8 binding#GO:0005488;signaling receptor binding#GO:0005102;protein binding#GO:0005515 anatomical structure development#GO:0048856;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;cell differentiation#GO:0030154;circulatory system development#GO:0072359;blood vessel morphogenesis#GO:0048514;tube morphogenesis#GO:0035239;blood vessel development#GO:0001568;anatomical structure morphogenesis#GO:0009653;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;vasculature development#GO:0001944;developmental process#GO:0032502;multicellular organismal process#GO:0032501;vasculogenesis#GO:0001570;tube development#GO:0035295;cellular process#GO:0009987 extracellular region#GO:0005576;cell surface#GO:0009986;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HUMAN|HGNC=11949|UniProtKB=P45379 P45379 TNNT2 PTHR11521:SF5 TROPONIN T TROPONIN T, CARDIAC MUSCLE protein binding#GO:0005515;binding#GO:0005488;cytoskeletal protein binding#GO:0008092 muscle contraction#GO:0006936;developmental process#GO:0032502;heart contraction#GO:0060047;system process#GO:0003008;cellular developmental process#GO:0048869;multicellular organismal process#GO:0032501;blood circulation#GO:0008015;actin filament-based process#GO:0030029;sarcomere organization#GO:0045214;cardiac muscle contraction#GO:0060048;circulatory system process#GO:0003013;cellular component assembly involved in morphogenesis#GO:0010927;organelle assembly#GO:0070925;supramolecular fiber organization#GO:0097435;anatomical structure development#GO:0048856;myofibril assembly#GO:0030239;muscle cell differentiation#GO:0042692;muscle cell development#GO:0055001;striated muscle contraction#GO:0006941;actin cytoskeleton organization#GO:0030036;muscle structure development#GO:0061061;cellular anatomical entity morphogenesis#GO:0032989;striated muscle cell differentiation#GO:0051146;anatomical structure formation involved in morphogenesis#GO:0048646;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;animal gross anatomical part developmental process#GO:0160108;striated muscle cell development#GO:0055002;heart process#GO:0003015;muscle system process#GO:0003012;anatomical structure morphogenesis#GO:0009653;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;cell development#GO:0048468;actomyosin structure organization#GO:0031032;cell differentiation#GO:0030154 myofibril#GO:0030016;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;actin cytoskeleton#GO:0015629;membraneless organelle#GO:0043228;sarcomere#GO:0030017;cytoskeleton#GO:0005856;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;contractile muscle fiber#GO:0043292 actin binding motor protein#PC00040 HUMAN|HGNC=33737|UniProtKB=Q5HYW2 Q5HYW2 NHSL2 PTHR23039:SF2 NANCE-HORAN SYNDROME PROTEIN NHS-LIKE PROTEIN 2 HUMAN|HGNC=26269|UniProtKB=Q0P6H9 Q0P6H9 TMEM62 PTHR14795:SF0 HELICASE RELATED TRANSMEMBRANE PROTEIN 62 RNA helicase#PC00032;RNA metabolism protein#PC00031 HUMAN|HGNC=31966|UniProtKB=Q2HXU8 Q2HXU8 CLEC12B PTHR47647:SF1 C-TYPE LECTIN DOMAIN FAMILY 12 MEMBER B C-TYPE LECTIN DOMAIN FAMILY 12 MEMBER B protein binding#GO:0005515;protein phosphatase binding#GO:0019903;binding#GO:0005488;phosphatase binding#GO:0019902;enzyme binding#GO:0019899 regulation of immune response#GO:0050776;regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;regulation of biological process#GO:0050789;signal transduction#GO:0007165;immune response-regulating signaling pathway#GO:0002764;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682 cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897 HUMAN|HGNC=32462|UniProtKB=A6NNF4 A6NNF4 ZNF726 PTHR23232:SF112 KRAB DOMAIN C2H2 ZINC FINGER ZINC FINGER PROTEIN 726 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=23570|UniProtKB=Q8TAL5 Q8TAL5 C9orf43 PTHR36130:SF1 RIKEN CDNA 4933430I17 GENE RIKEN CDNA 4933430I17 GENE HUMAN|HGNC=5607|UniProtKB=A0A0A0MS15 A0A0A0MS15 IGHV3-49 PTHR23266:SF385 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 3-49 antigen binding#GO:0003823;binding#GO:0005488 lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;immunoglobulin mediated immune response#GO:0016064;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immune system process#GO:0002376;immune effector process#GO:0002252;response to stimulus#GO:0050896;adaptive immune response#GO:0002250;immune response#GO:0006955 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=4327|UniProtKB=P23416 P23416 GLRA2 PTHR18945:SF28 NEUROTRANSMITTER GATED ION CHANNEL GLYCINE RECEPTOR SUBUNIT ALPHA-2 gated channel activity#GO:0022836;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic anion channel activity#GO:0005253;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;chloride transmembrane transporter activity#GO:0015108;chloride channel activity#GO:0005254;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;monoatomic anion transmembrane transporter activity#GO:0008509;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 chloride transport#GO:0006821;transport#GO:0006810;localization#GO:0051179;chloride transmembrane transport#GO:1902476;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;inorganic anion transport#GO:0015698;monoatomic ion transport#GO:0006811;monoatomic anion transport#GO:0006820;cellular process#GO:0009987;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220 cell junction#GO:0030054;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;synaptic membrane#GO:0097060;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;plasma membrane#GO:0005886;membrane#GO:0016020;postsynapse#GO:0098794;cell periphery#GO:0071944 ligand-gated ion channel#PC00141 HUMAN|HGNC=28040|UniProtKB=Q5U5Q3 Q5U5Q3 MEX3C PTHR23285:SF8 RING FINGER AND KH DOMAIN CONTAINING PROTEIN 1 RNA-BINDING E3 UBIQUITIN-PROTEIN LIGASE MEX3C RNA metabolism protein#PC00031 HUMAN|HGNC=15408|UniProtKB=P0C629 P0C629 OR10J4 PTHR26451:SF107 G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN OLFACTORY RECEPTOR 10J4 binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 sensory perception#GO:0007600;nervous system process#GO:0050877;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;system process#GO:0003008;detection of chemical stimulus#GO:0009593;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;response to stimulus#GO:0050896;response to chemical#GO:0042221;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608 cellular anatomical structure#GO:0110165;membrane#GO:0016020 G-protein coupled receptor#PC00021 HUMAN|HGNC=35159|UniProtKB=A8MTL0 A8MTL0 IQCF5 PTHR21633:SF24 IQ MOTIF CONTAINING F IQ DOMAIN-CONTAINING PROTEIN F5 HUMAN|HGNC=6637|UniProtKB=P20700 P20700 LMNB1 PTHR45721:SF3 LAMIN DM0-RELATED LAMIN-B1 structural molecule activity#GO:0005198;structural constituent of cytoskeleton#GO:0005200 nuclear migration#GO:0007097;heterochromatin formation#GO:0031507;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;protein localization to organelle#GO:0033365;organelle localization#GO:0051640;localization within membrane#GO:0051668;localization#GO:0051179;macromolecule localization#GO:0033036;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;epigenetic regulation of gene expression#GO:0040029;protein localization to nucleus#GO:0034504;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;membrane organization#GO:0061024;chromatin organization#GO:0006325;negative regulation of cellular process#GO:0048523;intracellular transport#GO:0046907;transport#GO:0006810;establishment of localization#GO:0051234;regulation of biosynthetic process#GO:0009889;nucleus organization#GO:0006997;intracellular protein localization#GO:0008104;nuclear envelope organization#GO:0006998;regulation of gene expression#GO:0010468;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;establishment of organelle localization#GO:0051656;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;cellular localization#GO:0051641;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;cellular component assembly#GO:0022607;endomembrane system organization#GO:0010256;heterochromatin organization#GO:0070828;cellular component organization or biogenesis#GO:0071840;negative regulation of gene expression, epigenetic#GO:0045814 nuclear periphery#GO:0034399;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;organelle envelope#GO:0031967;nucleus#GO:0005634;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635 FAS signaling pathway#P00020>Nuclear Lamin#P00616 HUMAN|HGNC=17129|UniProtKB=Q6P5W5 Q6P5W5 SLC39A4 PTHR12191:SF21 SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER ZIP4 transition metal ion transmembrane transporter activity#GO:0046915;symporter activity#GO:0015293;monoatomic cation transmembrane transporter activity#GO:0008324;zinc ion transmembrane transporter activity#GO:0005385;bicarbonate transmembrane transporter activity#GO:0015106;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;solute:monoatomic cation symporter activity#GO:0015294;monoatomic ion transmembrane transporter activity#GO:0015075;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873 import across plasma membrane#GO:0098739;homeostatic process#GO:0042592;metal ion transport#GO:0030001;inorganic ion import across plasma membrane#GO:0099587;intracellular monoatomic ion homeostasis#GO:0006873;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;zinc ion transmembrane transport#GO:0071577;transition metal ion transport#GO:0000041;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;zinc ion transport#GO:0006829;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;establishment of localization#GO:0051234;import into cell#GO:0098657;intracellular chemical homeostasis#GO:0055082;inorganic cation import across plasma membrane#GO:0098659;cellular homeostasis#GO:0019725;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;chemical homeostasis#GO:0048878;transport#GO:0006810 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227;secondary carrier transporter#PC00258 HUMAN|HGNC=26356|UniProtKB=Q96LI9 Q96LI9 CXorf58 PTHR33504:SF1 NADH DEHYDROGENASE (UBIQUINONE) 1 BETA SUBCOMPLEX, 4 SIMILAR TO HUMAN CHROMOSOME X OPEN READING FRAME 58 metabolite interconversion enzyme#PC00262;dehydrogenase#PC00092;oxidoreductase#PC00176 HUMAN|HGNC=12500|UniProtKB=O95155 O95155 UBE4B PTHR13931:SF2 UBIQUITINATION FACTOR E4 UBIQUITIN CONJUGATION FACTOR E4 B ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824 modification-dependent macromolecule catabolic process#GO:0043632;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;response to endoplasmic reticulum stress#GO:0034976;ERAD pathway#GO:0036503;protein metabolic process#GO:0019538;cellular response to stimulus#GO:0051716;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;catabolic process#GO:0009056;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;response to stress#GO:0006950;proteasomal protein catabolic process#GO:0010498;response to chemical#GO:0042221 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=31811|UniProtKB=P0C7V8 P0C7V8 DCAF8L2 PTHR15574:SF42 WD REPEAT DOMAIN-CONTAINING FAMILY DDB1- AND CUL4-ASSOCIATED FACTOR 8-LIKE PROTEIN 2 intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;transferase complex#GO:1990234;Cul4-RING E3 ubiquitin ligase complex#GO:0080008;cullin-RING ubiquitin ligase complex#GO:0031461;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=17848|UniProtKB=Q9Y2H1 Q9Y2H1 STK38L PTHR24356:SF160 SERINE/THREONINE-PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE 38-LIKE catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;establishment or maintenance of cell polarity#GO:0007163;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=18923|UniProtKB=Q52LG2 Q52LG2 KRTAP13-2 PTHR23262:SF246 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 13-1-RELATED structural protein#PC00211 HUMAN|HGNC=29418|UniProtKB=Q8TF40 Q8TF40 FNIP1 PTHR21634:SF12 RE13835P FOLLICULIN-INTERACTING PROTEIN 1 molecular function regulator activity#GO:0098772;molecular function inhibitor activity#GO:0140678;protein binding#GO:0005515;binding#GO:0005488;protein-folding chaperone binding#GO:0051087 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=11393|UniProtKB=O14965 O14965 AURKA PTHR24350:SF5 SERINE/THREONINE-PROTEIN KINASE IAL-RELATED AURORA KINASE A phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 regulation of cytokinesis#GO:0032465;regulation of cell division#GO:0051302;microtubule cytoskeleton organization#GO:0000226;regulation of biological process#GO:0050789;cell cycle process#GO:0022402;cell cycle#GO:0007049;cellular component organization#GO:0016043;microtubule cytoskeleton organization involved in mitosis#GO:1902850;regulation of cell cycle#GO:0051726;mitotic cell cycle#GO:0000278;mitotic spindle organization#GO:0007052;regulation of cellular process#GO:0050794;mitotic cell cycle process#GO:1903047;microtubule-based process#GO:0007017;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;organelle organization#GO:0006996;regulation of cell cycle process#GO:0010564;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007 intracellular organelle#GO:0043229;microtubule#GO:0005874;spindle microtubule#GO:0005876;membrane-bounded organelle#GO:0043227;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687;spindle midzone#GO:0051233;spindle pole#GO:0000922;chromosome#GO:0005694;kinetochore#GO:0000776;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;microtubule organizing center#GO:0005815;spindle#GO:0005819;centrosome#GO:0005813;condensed chromosome#GO:0000793;chromosome, centromeric region#GO:0000775;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;microtubule cytoskeleton#GO:0015630;condensed chromosome, centromeric region#GO:0000779;nucleus#GO:0005634;supramolecular complex#GO:0099080;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=12536|UniProtKB=P22310 P22310 UGT1A4 PTHR48050:SF12 STEROL 3-BETA-GLUCOSYLTRANSFERASE UDP-GLUCURONOSYLTRANSFERASE 1A3-RELATED enzyme binding#GO:0019899;binding#GO:0005488;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;protein binding#GO:0005515;enzyme inhibitor activity#GO:0004857;catalytic activity#GO:0003824;transferase activity#GO:0016740;molecular function regulator activity#GO:0098772;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757 response to steroid hormone#GO:0048545;system development#GO:0048731;anatomical structure development#GO:0048856;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;developmental process#GO:0032502;lipid metabolic process#GO:0006629;sterol metabolic process#GO:0016125;pigment metabolic process#GO:0042440;biological regulation#GO:0065007;hormone metabolic process#GO:0042445;multicellular organismal process#GO:0032501;cellular response to chemical stimulus#GO:0070887;animal gross anatomical part developmental process#GO:0160108;regulation of biological quality#GO:0065008;estrogen metabolic process#GO:0008210;regulation of hormone levels#GO:0010817;response to endogenous stimulus#GO:0009719;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;cellular response to hormone stimulus#GO:0032870;liver development#GO:0001889;metabolic process#GO:0008152;multicellular organism development#GO:0007275;cellular response to steroid hormone stimulus#GO:0071383;animal organ development#GO:0048513;cellular process#GO:0009987;response to hormone#GO:0009725;steroid metabolic process#GO:0008202;response to chemical#GO:0042221;response to lipid#GO:0033993;cellular response to lipid#GO:0071396 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 glycosyltransferase#PC00111;transferase#PC00220 Nicotine degradation#P05914>UGT1A4#P05982 HUMAN|HGNC=18487|UniProtKB=Q8IZP2 Q8IZP2 ST13P4 PTHR45883:SF3 HSC70-INTERACTING PROTEIN PROTEIN FAM10A4-RELATED protein binding#GO:0005515;Hsp70 protein binding#GO:0030544;protein-folding chaperone binding#GO:0051087;binding#GO:0005488;heat shock protein binding#GO:0031072 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;protein folding#GO:0006457;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 HUMAN|HGNC=24889|UniProtKB=Q6IPX1 Q6IPX1 TBC1D3C PTHR22957:SF571 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN TBC1 DOMAIN FAMILY MEMBER 3-RELATED molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme activator activity#GO:0008047 G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HUMAN|HGNC=4028|UniProtKB=P59646 P59646 FXYD4 PTHR14132:SF10 SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT GAMMA FXYD DOMAIN-CONTAINING ION TRANSPORT REGULATOR 4 transporter regulator activity#GO:0141108;ion channel regulator activity#GO:0099106;channel regulator activity#GO:0016247;molecular function regulator activity#GO:0098772 regulation of cellular process#GO:0050794;regulation of metal ion transport#GO:0010959;regulation of monoatomic ion transport#GO:0043269;biological regulation#GO:0065007;regulation of transmembrane transport#GO:0034762;regulation of monoatomic ion transmembrane transport#GO:0034765;regulation of biological process#GO:0050789;positive regulation of transport#GO:0051050;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of transport#GO:0051049;regulation of localization#GO:0032879;regulation of monoatomic cation transmembrane transport#GO:1904062 primary active transporter#PC00068;transporter#PC00227 HUMAN|HGNC=5927|UniProtKB=P01721 P01721 IGLV6-57 PTHR23267:SF108 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN LAMBDA VARIABLE 6-57 response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 protein-containing complex#GO:0032991 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=13449|UniProtKB=Q9H156 Q9H156 SLITRK2 PTHR45773:SF4 SLIT AND NTRK-LIKE PROTEIN 4-RELATED SLIT AND NTRK-LIKE PROTEIN 2 system development#GO:0048731;anatomical structure development#GO:0048856;regulation of nervous system development#GO:0051960;regulation of synapse structure or activity#GO:0050803;regulation of cell junction assembly#GO:1901888;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;neurogenesis#GO:0022008;positive regulation of synapse assembly#GO:0051965;cellular developmental process#GO:0048869;neuron projection morphogenesis#GO:0048812;positive regulation of developmental process#GO:0051094;developmental process#GO:0032502;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regulation of synapse assembly#GO:0051963;positive regulation of cellular process#GO:0048522;axon development#GO:0061564;regulation of biological quality#GO:0065008;axonogenesis#GO:0007409;neuron development#GO:0048666;regulation of synapse organization#GO:0050807;generation of neurons#GO:0048699;positive regulation of cellular component organization#GO:0051130;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;regulation of cellular component biogenesis#GO:0044087;cell morphogenesis#GO:0000902;positive regulation of nervous system development#GO:0051962;cell projection organization#GO:0030030;cell differentiation#GO:0030154;regulation of cellular component organization#GO:0051128;positive regulation of multicellular organismal process#GO:0051240;regulation of multicellular organismal development#GO:2000026;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;cell projection morphogenesis#GO:0048858;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;regulation of multicellular organismal process#GO:0051239;positive regulation of cellular component biogenesis#GO:0044089;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;neuron projection development#GO:0031175 cellular anatomical structure#GO:0110165;synapse#GO:0045202;glutamatergic synapse#GO:0098978;cell junction#GO:0030054 transmembrane signal receptor#PC00197 HUMAN|HGNC=32235|UniProtKB=Q8N0T1 Q8N0T1 RBIS PTHR35544:SF4 RIBOSOMAL BIOGENESIS FACTOR RIBOSOMAL BIOGENESIS FACTOR HUMAN|HGNC=10402|UniProtKB=P39019 P39019 RPS19 PTHR11710:SF32 40S RIBOSOMAL PROTEIN S19 SMALL RIBOSOMAL SUBUNIT PROTEIN ES19 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;ribosomal small subunit biogenesis#GO:0042274;gene expression#GO:0010467;maturation of SSU-rRNA#GO:0030490;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;ribosome#GO:0005840;cytosol#GO:0005829;cytosolic ribosome#GO:0022626;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;small ribosomal subunit#GO:0015935;intracellular organelle#GO:0043229;cytosolic small ribosomal subunit#GO:0022627;ribonucleoprotein complex#GO:1990904 ribosomal protein#PC00202 HUMAN|HGNC=14523|UniProtKB=Q96MW7 Q96MW7 TIGD1 PTHR19303:SF26 TRANSPOSON TIGGER TRANSPOSABLE ELEMENT-DERIVED PROTEIN 1 DNA binding#GO:0003677;nucleic acid binding#GO:0003676;binding#GO:0005488 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 viral or transposable element protein#PC00237 HUMAN|HGNC=9594|UniProtKB=P43116 P43116 PTGER2 PTHR11866:SF8 G-PROTEIN COUPLED RECEPTOR FAMILY 1 MEMBER PROSTAGLANDIN E2 RECEPTOR EP2 SUBTYPE signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 response to endogenous stimulus#GO:0009719;cellular response to alcohol#GO:0097306;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;cellular response to hormone stimulus#GO:0032870;response to stimulus#GO:0050896;response to alcohol#GO:0097305;cellular response to endogenous stimulus#GO:0071495;signaling#GO:0023052;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;positive regulation of cytosolic calcium ion concentration#GO:0007204;response to oxygen-containing compound#GO:1901700;cell communication#GO:0007154;regulation of biological quality#GO:0065008;response to hormone#GO:0009725;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;cellular response to lipid#GO:0071396;response to lipid#GO:0033993;response to chemical#GO:0042221;biological regulation#GO:0065007;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 Gonadotropin-releasing hormone receptor pathway#P06664>PG Rcs#P06836 HUMAN|HGNC=31109|UniProtKB=P0C2S0 P0C2S0 CTXN2 PTHR16736:SF2 CORTEXIN-1-RELATED CORTEXIN-2 HUMAN|HGNC=1516|UniProtKB=P04040 P04040 CAT PTHR11465:SF9 CATALASE CATALASE tetrapyrrole binding#GO:0046906;oxidoreductase activity, acting on peroxide as acceptor#GO:0016684;binding#GO:0005488;oxidoreductase activity#GO:0016491;heme binding#GO:0020037;peroxidase activity#GO:0004601;antioxidant activity#GO:0016209;catalytic activity#GO:0003824 response to oxidative stress#GO:0006979;response to reactive oxygen species#GO:0000302;metabolic process#GO:0008152;reactive oxygen species metabolic process#GO:0072593;response to oxygen-containing compound#GO:1901700;catabolic process#GO:0009056;response to stimulus#GO:0050896;response to chemical#GO:0042221;hydrogen peroxide metabolic process#GO:0042743;response to stress#GO:0006950;cellular process#GO:0009987 mitochondrion#GO:0005739;microbody#GO:0042579;peroxisome#GO:0005777;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 peroxidase#PC00180 HUMAN|HGNC=17693|UniProtKB=O75911 O75911 DHRS3 PTHR24322:SF483 PKSB SHORT-CHAIN DEHYDROGENASE_REDUCTASE 3 oxidoreductase activity#GO:0016491;alcohol dehydrogenase (NAD+) activity#GO:0004022;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;all-trans-retinol dehydrogenase (NAD+) activity#GO:0004745;catalytic activity#GO:0003824;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 metabolic process#GO:0008152;regulation of response to stimulus#GO:0048583;lipid metabolic process#GO:0006629;retinoid metabolic process#GO:0001523;diterpenoid metabolic process#GO:0016101;cellular process#GO:0009987;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;terpenoid metabolic process#GO:0006721;isoprenoid metabolic process#GO:0006720;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;lipid droplet#GO:0005811;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228;cellular anatomical structure#GO:0110165;organelle#GO:0043226 dehydrogenase#PC00092 HUMAN|HGNC=29559|UniProtKB=Q96GC9 Q96GC9 VMP1 PTHR10281:SF121 MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED VACUOLE MEMBRANE PROTEIN 1 lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104;transporter activity#GO:0005215;phospholipid scramblase activity#GO:0017128;intramembrane lipid carrier activity#GO:0140303 vacuole organization#GO:0007033;process utilizing autophagic mechanism#GO:0061919;organelle assembly#GO:0070925;catabolic process#GO:0009056;cellular component organization#GO:0016043;Golgi organization#GO:0007030;cellular component organization or biogenesis#GO:0071840;autophagosome assembly#GO:0000045;metabolic process#GO:0008152;cellular component assembly#GO:0022607;endomembrane system organization#GO:0010256;macroautophagy#GO:0016236;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;autophagy#GO:0006914;autophagosome organization#GO:1905037;cellular process#GO:0009987 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=29412|UniProtKB=Q6P995 Q6P995 FAM171B PTHR31626:SF2 SUSHI DOMAIN-CONTAINING PROTEIN PROTEIN FAM171B HUMAN|HGNC=28712|UniProtKB=Q8N412 Q8N412 STPG2 PTHR21580:SF64 SHIPPO-1-RELATED SPERM-TAIL PG-RICH REPEAT-CONTAINING PROTEIN 2 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membraneless organelle#GO:0043228 structural protein#PC00211 HUMAN|HGNC=7111|UniProtKB=Q9HBH9 Q9HBH9 MKNK2 PTHR24349:SF254 SERINE/THREONINE-PROTEIN KINASE MAP KINASE-INTERACTING SERINE_THREONINE-PROTEIN KINASE 2 catalytic activity, acting on a protein#GO:0140096;calmodulin binding#GO:0005516;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein binding#GO:0005515;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;binding#GO:0005488;calcium/calmodulin-dependent protein kinase activity#GO:0004683 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 Interleukin signaling pathway#P00036>MNK1/2#P00972;PDGF signaling pathway#P00047>MNK1/2#P01149;p38 MAPK pathway#P05918>MNK2#P06017;Oxidative stress response#P00046>MNK1/2#P01137 HUMAN|HGNC=14061|UniProtKB=O60711 O60711 LPXN PTHR24216:SF23 PAXILLIN-RELATED LEUPAXIN transcription regulator activity#GO:0140110;protein sequestering activity#GO:0140311;transcription coregulator activity#GO:0003712;molecular sequestering activity#GO:0140313 negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;negative regulation of response to stimulus#GO:0048585;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;negative regulation of immune system process#GO:0002683;biological regulation#GO:0065007;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;regulation of immune response#GO:0050776;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of cell communication#GO:0010646;regulation of B cell receptor signaling pathway#GO:0050855 cell junction#GO:0030054;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;nucleus#GO:0005634;cell-cell junction#GO:0005911;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;intracellular organelle#GO:0043229;focal adhesion#GO:0005925;cell projection#GO:0042995;cell-substrate junction#GO:0030055;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;actin-based cell projection#GO:0098858;actin cytoskeleton#GO:0015629 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 VEGF signaling pathway#P00056>Paxillin#P01418;Angiogenesis#P00005>Paxillin#P00194 HUMAN|HGNC=16053|UniProtKB=Q8N1V2 Q8N1V2 CFAP52 PTHR13720:SF14 WD-40 REPEAT PROTEIN CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 52 microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=18331|UniProtKB=Q6NT04 Q6NT04 TIGD7 PTHR19303:SF17 TRANSPOSON TIGGER TRANSPOSABLE ELEMENT-DERIVED PROTEIN 7 DNA binding#GO:0003677;binding#GO:0005488;nucleic acid binding#GO:0003676 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 viral or transposable element protein#PC00237 HUMAN|HGNC=18817|UniProtKB=Q86YV9 Q86YV9 HPS6 PTHR14696:SF2 HERMANSKY-PUDLAK SYNDROME 6 PROTEIN BLOC-2 COMPLEX MEMBER HPS6 protein localization to membrane#GO:0072657;macromolecule localization#GO:0033036;cellular process#GO:0009987;lysosome localization#GO:0032418;organelle localization#GO:0051640;localization within membrane#GO:0051668;cellular localization#GO:0051641;localization#GO:0051179;intracellular protein localization#GO:0008104 lytic vacuole membrane#GO:0098852;lysosome#GO:0005764;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;lysosomal membrane#GO:0005765;protein-containing complex#GO:0032991;vacuole#GO:0005773;cytoplasm#GO:0005737;lytic vacuole#GO:0000323;vacuolar membrane#GO:0005774;bounding membrane of organelle#GO:0098588;intracellular protein-containing complex#GO:0140535;organelle membrane#GO:0031090 HUMAN|HGNC=37619|UniProtKB=A6NIE6 A6NIE6 RRN3P2 PTHR12790:SF0 TRANSCRIPTION INITIATION FACTOR IA RRN3 RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN3-RELATED DNA-templated transcription initiation#GO:0006352;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;transcription by RNA polymerase I#GO:0006360;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;transcription initiation at RNA polymerase I promoter#GO:0006361;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 general transcription factor#PC00259 General transcription by RNA polymerase I#P00022>RNA Polymerase I Complex#P00652 HUMAN|HGNC=5003|UniProtKB=Q9UGU5 Q9UGU5 HMGXB4 PTHR46584:SF1 HMG DOMAIN-CONTAINING PROTEIN 4 HMG DOMAIN-CONTAINING PROTEIN 4 HMG box transcription factor#PC00024 HUMAN|HGNC=23606|UniProtKB=Q6L8G4 Q6L8G4 KRTAP5-11 PTHR23262:SF134 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 5-11 structural protein#PC00211 HUMAN|HGNC=7518|UniProtKB=Q8TAX7 Q8TAX7 MUC7 PTHR41683:SF1 MUCIN-7 MUCIN-7 HUMAN|HGNC=30492|UniProtKB=Q8N9W5 Q8N9W5 DNAAF3 PTHR22118:SF14 DYNEIN ASSEMBLY FACTOR 3, AXONEMAL DYNEIN AXONEMAL ASSEMBLY FACTOR 3 organelle assembly#GO:0070925;microtubule bundle formation#GO:0001578;axonemal dynein complex assembly#GO:0070286;microtubule cytoskeleton organization#GO:0000226;cilium organization#GO:0044782;axoneme assembly#GO:0035082;cilium assembly#GO:0060271;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;cell projection organization#GO:0030030;plasma membrane bounded cell projection assembly#GO:0120031;motile cilium assembly#GO:0044458;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;protein-containing complex organization#GO:0043933;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton organization#GO:0007010 chaperone#PC00072 HUMAN|HGNC=591|UniProtKB=Q13489 Q13489 BIRC3 PTHR10044:SF178 INHIBITOR OF APOPTOSIS BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 3 catalytic activity#GO:0003824;transferase activity#GO:0016740;molecular function regulator activity#GO:0098772;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;enzyme regulator activity#GO:0030234 regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;regulation of protein modification by small protein conjugation or removal#GO:1903320;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of cell cycle#GO:0051726;positive regulation of protein metabolic process#GO:0051247;regulation of post-translational protein modification#GO:1901873;positive regulation of metabolic process#GO:0009893;regulation of primary metabolic process#GO:0080090;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;negative regulation of programmed cell death#GO:0043069;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;negative regulation of apoptotic process#GO:0043066;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of protein ubiquitination#GO:0031398;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;regulation of apoptotic process#GO:0042981;regulation of protein ubiquitination#GO:0031396;regulation of protein modification process#GO:0031399 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 protease inhibitor#PC00191;protein-binding activity modulator#PC00095 Apoptosis signaling pathway#P00006>c-IAP1,2#P00264;CCKR signaling map#P06959>BIRC3#G07286 HUMAN|HGNC=10532|UniProtKB=O75446 O75446 SAP30 PTHR13286:SF7 SAP30 HISTONE DEACETYLASE COMPLEX SUBUNIT SAP30 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255 nuclear protein-containing complex#GO:0140513;protein-containing complex#GO:0032991;histone deacetylase complex#GO:0000118;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=4716|UniProtKB=P16403 P16403 H1-2 PTHR11467:SF86 HISTONE H1 HISTONE H1.2 DNA binding#GO:0003677;protein-containing complex binding#GO:0044877;double-stranded DNA binding#GO:0003690;nucleosome binding#GO:0031491;binding#GO:0005488;nucleic acid binding#GO:0003676;chromatin binding#GO:0003682;chromatin DNA binding#GO:0031490 negative regulation of nucleobase-containing compound metabolic process#GO:0045934;chromosome condensation#GO:0030261;regulation of DNA recombination#GO:0000018;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of metabolic process#GO:0009892;cellular component organization#GO:0016043;negative regulation of DNA recombination#GO:0045910;negative regulation of biological process#GO:0048519;regulation of DNA metabolic process#GO:0051052;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;chromosome organization#GO:0051276;negative regulation of cellular process#GO:0048523;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of DNA metabolic process#GO:0051053;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;organelle organization#GO:0006996;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605 intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;chromosome#GO:0005694;chromatin#GO:0000785;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=30452|UniProtKB=A1XBS5 A1XBS5 CIBAR1 PTHR21223:SF4 CBY1-INTERACTING BAR DOMAIN-CONTAINING PROTEIN HOMOLOG CBY1-INTERACTING BAR DOMAIN-CONTAINING PROTEIN 1 plasma membrane bounded cell projection assembly#GO:0120031;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component assembly#GO:0022607;cell projection organization#GO:0030030;plasma membrane bounded cell projection organization#GO:0120036 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;cilium#GO:0005929;intracellular organelle#GO:0043229;microtubule organizing center#GO:0005815;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;ciliary transition zone#GO:0035869;intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microtubule cytoskeleton#GO:0015630 HUMAN|HGNC=1424|UniProtKB=P27708 P27708 CAD PTHR11405:SF5 CARBAMOYLTRANSFERASE FAMILY MEMBER MULTIFUNCTIONAL PROTEIN CAD ligase activity#GO:0016874;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides#GO:0016812;ligase activity, forming carbon-nitrogen bonds#GO:0016879;hydrolase activity#GO:0016787 nucleobase-containing small molecule metabolic process#GO:0055086;nucleobase metabolic process#GO:0009112;pyrimidine nucleobase metabolic process#GO:0006206;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;amino acid metabolic process#GO:0006520;small molecule metabolic process#GO:0044281;proteinogenic amino acid metabolic process#GO:0170039;pyrimidine-containing compound metabolic process#GO:0072527;cellular process#GO:0009987;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 ligase#PC00142;metabolite interconversion enzyme#PC00262 De novo pyrimidine ribonucleotides biosythesis#P02740>Carbamoyl phosphate synthetase#P02925;Arginine biosynthesis#P02728>Carbamoyl phosphate synthase#P02845 HUMAN|HGNC=1837|UniProtKB=P53567 P53567 CEBPG PTHR23334:SF69 CCAAT/ENHANCER BINDING PROTEIN CCAAT_ENHANCER-BINDING PROTEIN GAMMA binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 DNA-binding transcription factor#PC00218;basic leucine zipper transcription factor#PC00056 HUMAN|HGNC=34385|UniProtKB=B2RC85 B2RC85 RSPH10B2 PTHR46613:SF1 RADIAL SPOKE HEAD 10 HOMOLOG B-RELATED RADIAL SPOKE HEAD 10 HOMOLOG B-RELATED HUMAN|HGNC=14510|UniProtKB=Q96EL2 Q96EL2 MRPS24 PTHR21244:SF1 MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S24 SMALL RIBOSOMAL SUBUNIT PROTEIN US3M translational protein#PC00263;ribosomal protein#PC00202 HUMAN|HGNC=7181|UniProtKB=P51948 P51948 MNAT1 PTHR12683:SF13 CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1 CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;transcription initiation at RNA polymerase II promoter#GO:0006367;response to stress#GO:0006950;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;nucleobase-containing compound biosynthetic process#GO:0034654;transcription by RNA polymerase II#GO:0006366;DNA damage response#GO:0006974;response to stimulus#GO:0050896;DNA-templated transcription initiation#GO:0006352;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular response to stimulus#GO:0051716;RNA metabolic process#GO:0016070;cellular response to stress#GO:0033554;nucleic acid biosynthetic process#GO:0141187 protein-containing complex#GO:0032991;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;membrane-enclosed lumen#GO:0031974;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;protein kinase complex#GO:1902911;transcription regulator complex#GO:0005667;transferase complex#GO:1990234;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;RNA polymerase II, holoenzyme#GO:0016591;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554;transcription factor TFIIH holo complex#GO:0005675;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 chaperone#PC00072 HUMAN|HGNC=9758|UniProtKB=P62820 P62820 RAB1A PTHR24073:SF963 DRAB5-RELATED RAS-RELATED PROTEIN RAB-1A catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111 cellular component organization#GO:0016043;catabolic process#GO:0009056;organelle assembly#GO:0070925;process utilizing autophagic mechanism#GO:0061919;protein transport#GO:0015031;vacuole organization#GO:0007033;cellular localization#GO:0051641;localization#GO:0051179;autophagosome organization#GO:1905037;cellular process#GO:0009987;establishment of protein localization#GO:0045184;autophagy#GO:0006914;establishment of localization in cell#GO:0051649;cellular component biogenesis#GO:0044085;macromolecule localization#GO:0033036;organelle organization#GO:0006996;macroautophagy#GO:0016236;cellular component assembly#GO:0022607;intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907;metabolic process#GO:0008152;autophagosome assembly#GO:0000045;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;neuronal cell body#GO:0043025;somatodendritic compartment#GO:0036477;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cell body#GO:0044297 G-protein#PC00020;small GTPase#PC00208 HUMAN|HGNC=26719|UniProtKB=Q8N9N7 Q8N9N7 LRRC57 PTHR16083:SF21 LEUCINE RICH REPEAT CONTAINING PROTEIN LEUCINE-RICH REPEAT-CONTAINING PROTEIN 57 scaffold/adaptor protein#PC00226 HUMAN|HGNC=19895|UniProtKB=Q96PP8 Q96PP8 GBP5 PTHR10751:SF40 GUANYLATE BINDING PROTEIN GUANYLATE-BINDING PROTEIN 5 peptidase regulator activity#GO:0061134;GTPase activity#GO:0003924;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;molecular function inhibitor activity#GO:0140678;hydrolase activity#GO:0016787;enzyme regulator activity#GO:0030234;hydrolase activity, acting on acid anhydrides#GO:0016817;enzyme inhibitor activity#GO:0004857;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;molecular function regulator activity#GO:0098772;ribonucleoside triphosphate phosphatase activity#GO:0017111;endopeptidase inhibitor activity#GO:0004866 response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;antiviral innate immune response#GO:0140374;defense response to virus#GO:0051607;response to virus#GO:0009615;immune system process#GO:0002376;response to other organism#GO:0051707;defense response to other organism#GO:0098542;defense response to symbiont#GO:0140546;immune response#GO:0006955;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;response to external stimulus#GO:0009605;defense response#GO:0006952;innate immune response#GO:0045087 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708 G-protein#PC00020;heterotrimeric G-protein#PC00117 HUMAN|HGNC=1775|UniProtKB=Q15078 Q15078 CDK5R1 PTHR23401:SF2 CYCLIN DEPENDANT KINASE-5 ACTIVATOR CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 1 kinase activator activity#GO:0019209;protein kinase activator activity#GO:0030295;molecular function regulator activity#GO:0098772;cyclin-dependent protein kinase regulator activity#GO:0019914;binding#GO:0005488;kinase binding#GO:0019900;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;protein binding#GO:0005515;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;enzyme activator activity#GO:0008047;protein serine/threonine kinase activator activity#GO:0043539;cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538;kinase regulator activity#GO:0019207;protein kinase regulator activity#GO:0019887 neuron projection development#GO:0031175;cellular process#GO:0009987;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;head development#GO:0060322;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;animal organ development#GO:0048513;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cell projection morphogenesis#GO:0048858;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cell morphogenesis#GO:0000902;cell differentiation#GO:0030154;cell projection organization#GO:0030030;central nervous system development#GO:0007417;cell development#GO:0048468;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;axonogenesis#GO:0007409;neuron development#GO:0048666;axon development#GO:0061564;axon guidance#GO:0007411;multicellular organismal process#GO:0032501;brain development#GO:0007420;plasma membrane bounded cell projection organization#GO:0120036;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;neuron projection guidance#GO:0097485;anatomical structure development#GO:0048856;system development#GO:0048731 intracellular anatomical structure#GO:0005622;site of polarized growth#GO:0030427;growth cone#GO:0030426;axon#GO:0030424;cellular anatomical structure#GO:0110165;distal axon#GO:0150034;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;neuron projection#GO:0043005 kinase modulator#PC00140;kinase activator#PC00138 HUMAN|HGNC=3062|UniProtKB=Q9NRD9 Q9NRD9 DUOX1 PTHR11972:SF75 NADPH OXIDASE DUAL OXIDASE 1 catalytic activity#GO:0003824;oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor#GO:0050664;oxidoreductase activity, acting on NAD(P)H#GO:0016651;oxidoreductase activity#GO:0016491 defense response#GO:0006952;superoxide metabolic process#GO:0006801;response to stimulus#GO:0050896;cellular process#GO:0009987;reactive oxygen species metabolic process#GO:0072593;response to stress#GO:0006950;metabolic process#GO:0008152 catalytic complex#GO:1902494;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane#GO:0016020;oxidoreductase complex#GO:1990204;membrane protein complex#GO:0098796 metabolite interconversion enzyme#PC00262;oxidase#PC00175 HUMAN|HGNC=838|UniProtKB=P56381 P56381 ATP5F1E PTHR12448:SF1 ATP SYNTHASE EPSILON CHAIN, MITOCHONDRIAL ATP SYNTHASE F(1) COMPLEX SUBUNIT EPSILON, MITOCHONDRIAL proton channel activity#GO:0015252;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic cation channel activity#GO:0005261;ligase activity#GO:0016874;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;passive transmembrane transporter activity#GO:0022803;proton transmembrane transporter activity#GO:0015078;catalytic activity#GO:0003824;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;proton-transporting ATP synthase activity, rotational mechanism#GO:0046933 ribose phosphate biosynthetic process#GO:0046390;cellular process#GO:0009987;ATP metabolic process#GO:0046034;ribose phosphate metabolic process#GO:0019693;metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing compound biosynthetic process#GO:0034654;ATP biosynthetic process#GO:0006754;carbohydrate derivative biosynthetic process#GO:1901137;ribonucleoside triphosphate biosynthetic process#GO:0009201;nucleobase-containing small molecule metabolic process#GO:0055086;phosphorus metabolic process#GO:0006793;purine nucleotide metabolic process#GO:0006163;proton motive force-driven mitochondrial ATP synthesis#GO:0042776;purine-containing compound metabolic process#GO:0072521;small molecule metabolic process#GO:0044281;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;ribonucleotide metabolic process#GO:0009259;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide biosynthetic process#GO:0009165;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;nucleoside triphosphate biosynthetic process#GO:0009142;carbohydrate derivative metabolic process#GO:1901135;purine ribonucleoside triphosphate metabolic process#GO:0009205;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;purine ribonucleoside triphosphate biosynthetic process#GO:0009206;generation of precursor metabolites and energy#GO:0006091;nucleoside phosphate biosynthetic process#GO:1901293;energy derivation by oxidation of organic compounds#GO:0015980;primary metabolic process#GO:0044238;purine nucleoside triphosphate metabolic process#GO:0009144;purine nucleoside triphosphate biosynthetic process#GO:0009145;proton motive force-driven ATP synthesis#GO:0015986;nucleoside phosphate metabolic process#GO:0006753;nucleoside triphosphate metabolic process#GO:0009141;oxidative phosphorylation#GO:0006119;organophosphate biosynthetic process#GO:0090407;cellular respiration#GO:0045333;aerobic respiration#GO:0009060 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrial inner membrane#GO:0005743;organelle envelope#GO:0031967;membrane#GO:0016020;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866 ATP synthase#PC00002 HUMAN|HGNC=10060|UniProtKB=Q9BXT8 Q9BXT8 RNF17 PTHR16442:SF1 RING FINGER PROTEIN 17 RING FINGER PROTEIN 17 HUMAN|HGNC=6177|UniProtKB=Q13572 Q13572 ITPK1 PTHR14217:SF25 INOSITOL-TETRAKISPHOSPHATE 1-KINASE INOSITOL-TETRAKISPHOSPHATE 1-KINASE phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 kinase#PC00137;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=33632|UniProtKB=A6NMK7 A6NMK7 CPSF4L PTHR23102:SF19 CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4-RELATED CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4-LIKE PROTEIN-RELATED macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;nucleobase-containing compound biosynthetic process#GO:0034654;mRNA 3'-end processing#GO:0031124;metabolic process#GO:0008152;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mRNA cleavage and polyadenylation specificity factor complex#GO:0005847;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;mRNA cleavage factor complex#GO:0005849;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 RNA splicing factor#PC00148 HUMAN|HGNC=820|UniProtKB=P51164 P51164 ATP4B PTHR11523:SF11 SODIUM/POTASSIUM-DEPENDENT ATPASE BETA SUBUNIT POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA ATPase activator activity#GO:0001671;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772 chemical homeostasis#GO:0048878;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;transport#GO:0006810;potassium ion import across plasma membrane#GO:1990573;establishment of localization#GO:0051234;import into cell#GO:0098657;intracellular chemical homeostasis#GO:0055082;inorganic cation import across plasma membrane#GO:0098659;cellular homeostasis#GO:0019725;monoatomic ion homeostasis#GO:0050801;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;potassium ion transport#GO:0006813;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;monoatomic ion transmembrane transport#GO:0034220;inorganic ion homeostasis#GO:0098771;localization#GO:0051179;potassium ion homeostasis#GO:0055075;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;intracellular monoatomic ion homeostasis#GO:0006873;sodium ion transport#GO:0006814;import across plasma membrane#GO:0098739;metal ion transport#GO:0030001;export from cell#GO:0140352;homeostatic process#GO:0042592;inorganic ion import across plasma membrane#GO:0099587 transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;ATPase dependent transmembrane transport complex#GO:0098533;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;cation-transporting ATPase complex#GO:0090533 primary active transporter#PC00068;transporter#PC00227 HUMAN|HGNC=6768|UniProtKB=Q15796 Q15796 SMAD2 PTHR13703:SF42 SMAD SMAD FAMILY MEMBER 2 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;protein binding#GO:0005515 regulation of macromolecule metabolic process#GO:0060255;response to growth factor#GO:0070848;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;BMP signaling pathway#GO:0030509;cellular response to transforming growth factor beta stimulus#GO:0071560;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;positive regulation of biosynthetic process#GO:0009891;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of RNA metabolic process#GO:0051252;intracellular signal transduction#GO:0035556;response to transforming growth factor beta#GO:0071559;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of cellular process#GO:0048522;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;response to BMP#GO:0071772;developmental process#GO:0032502;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;cellular response to endogenous stimulus#GO:0071495;cell differentiation#GO:0030154;signaling#GO:0023052;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;cellular response to growth factor stimulus#GO:0071363;activin receptor signaling pathway#GO:0032924;positive regulation of macromolecule metabolic process#GO:0010604;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;intracellular signaling cassette#GO:0141124;transforming growth factor beta receptor signaling pathway#GO:0007179;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of transcription by RNA polymerase II#GO:0045944;cellular response to BMP stimulus#GO:0071773;cell surface receptor signaling pathway#GO:0007166 intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 Gonadotropin-releasing hormone receptor pathway#P06664>SMAD2-4#P06819;TGF-beta signaling pathway#P00052>RSmads#P01292 HUMAN|HGNC=13869|UniProtKB=P58215 P58215 LOXL3 PTHR45817:SF2 LYSYL OXIDASE-LIKE-RELATED LYSYL OXIDASE HOMOLOG 3 oxidoreductase activity#GO:0016491;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular process#GO:0009987;extracellular structure organization#GO:0043062;cellular component organization#GO:0016043;external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198;collagen fibril organization#GO:0030199;cellular component organization or biogenesis#GO:0071840 extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical structure#GO:0110165 oxidase#PC00175;oxidoreductase#PC00176 HUMAN|HGNC=8524|UniProtKB=Q12889 Q12889 OVGP1 PTHR11177:SF248 CHITINASE OVIDUCT-SPECIFIC GLYCOPROTEIN hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;chitinase activity#GO:0004568;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553 cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;amino sugar metabolic process#GO:0006040;catabolic process#GO:0009056;carbohydrate derivative catabolic process#GO:1901136;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;aminoglycan metabolic process#GO:0006022;chitin metabolic process#GO:0006030;aminoglycan catabolic process#GO:0006026;chitin catabolic process#GO:0006032;amino sugar catabolic process#GO:0046348;macromolecule metabolic process#GO:0043170 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;glycosidase#PC00110 HUMAN|HGNC=2301|UniProtKB=O75976 O75976 CPD PTHR11532:SF73 PROTEASE M14 CARBOXYPEPTIDASE CARBOXYPEPTIDASE D metalloexopeptidase activity#GO:0008235;catalytic activity#GO:0003824;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;metallopeptidase activity#GO:0008237;carboxypeptidase activity#GO:0004180;hydrolase activity#GO:0016787;metallocarboxypeptidase activity#GO:0004181;exopeptidase activity#GO:0008238 cellular process#GO:0009987;protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467;metabolic process#GO:0008152;proteolysis#GO:0006508;peptide metabolic process#GO:0006518;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease#PC00190 HUMAN|HGNC=5586|UniProtKB=A0A0B4J1V1 A0A0B4J1V1 IGHV3-21 PTHR23266:SF357 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 3-11-RELATED antigen binding#GO:0003823;binding#GO:0005488 immune system process#GO:0002376;immune effector process#GO:0002252;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;immunoglobulin mediated immune response#GO:0016064;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immune response#GO:0006955;response to stimulus#GO:0050896;adaptive immune response#GO:0002250 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=14262|UniProtKB=Q8WXX7 Q8WXX7 AUTS2 PTHR14429:SF5 FIBROSIN FAMILY MEMBER AUTISM SUSCEPTIBILITY GENE 2 PROTEIN HUMAN|HGNC=27452|UniProtKB=Q4G0X4 Q4G0X4 KCTD21 PTHR14499:SF57 POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD21 enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;catabolic process#GO:0009056;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238 scaffold/adaptor protein#PC00226 HUMAN|HGNC=4551|UniProtKB=Q9NZ01 Q9NZ01 TECR PTHR10556:SF31 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE VERY-LONG-CHAIN ENOYL-COA REDUCTASE catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;oxidoreductase activity#GO:0016491 oxoacid metabolic process#GO:0043436;carboxylic acid biosynthetic process#GO:0046394;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;very long-chain fatty acid metabolic process#GO:0000038;small molecule metabolic process#GO:0044281;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152;sphingolipid metabolic process#GO:0006665;fatty acid metabolic process#GO:0006631;monocarboxylic acid biosynthetic process#GO:0072330;cellular process#GO:0009987;biosynthetic process#GO:0009058;fatty acid biosynthetic process#GO:0006633;lipid biosynthetic process#GO:0008610 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=16834|UniProtKB=Q16612 Q16612 NREP PTHR17102:SF4 NEURONAL REGENERATION-RELATED PROTEIN NEURONAL REGENERATION-RELATED PROTEIN neurogenesis#GO:0022008;cellular developmental process#GO:0048869;developmental process#GO:0032502;regulation of cell differentiation#GO:0045595;regulation of response to stimulus#GO:0048583;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cellular response to growth factor stimulus#GO:0090287;plasma membrane bounded cell projection organization#GO:0120036;regulation of neuron differentiation#GO:0045664;multicellular organismal process#GO:0032501;axon development#GO:0061564;response to wounding#GO:0009611;system development#GO:0048731;anatomical structure development#GO:0048856;regulation of developmental process#GO:0050793;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of transforming growth factor beta receptor signaling pathway#GO:0017015;cellular response to stimulus#GO:0051716;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;neuron differentiation#GO:0030182;regeneration#GO:0031099;nervous system development#GO:0007399;cellular process#GO:0009987;neuron projection development#GO:0031175;response to stress#GO:0006950;neuron development#GO:0048666;generation of neurons#GO:0048699;cellular response to stress#GO:0033554;regulation of signaling#GO:0023051;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;cell projection organization#GO:0030030;response to stimulus#GO:0050896;cell differentiation#GO:0030154;regulation of biological process#GO:0050789;cellular component organization#GO:0016043 HUMAN|HGNC=24948|UniProtKB=Q8TEK3 Q8TEK3 DOT1L PTHR21451:SF0 HISTONE H3 METHYLTRANSFERASE HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC protein methyltransferase activity#GO:0008276;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;N-methyltransferase activity#GO:0008170;histone methyltransferase activity#GO:0042054;protein-lysine N-methyltransferase activity#GO:0016279;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;histone H3 methyltransferase activity#GO:0140938;histone modifying activity#GO:0140993;lysine N-methyltransferase activity#GO:0016278 negative regulation of cell cycle#GO:0045786;cellular component organization or biogenesis#GO:0071840;negative regulation of gene expression, epigenetic#GO:0045814;constitutive heterochromatin formation#GO:0140719;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;cell cycle checkpoint signaling#GO:0000075;cellular component assembly#GO:0022607;regulation of cell cycle process#GO:0010564;heterochromatin organization#GO:0070828;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;response to stress#GO:0006950;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;regulation of cell cycle#GO:0051726;signaling#GO:0023052;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;negative regulation of cell cycle phase transition#GO:1901988;signal transduction in response to DNA damage#GO:0042770;regulation of biological process#GO:0050789;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;DNA repair#GO:0006281;negative regulation of cellular process#GO:0048523;DNA damage response#GO:0006974;negative regulation of cell cycle process#GO:0010948;DNA damage checkpoint signaling#GO:0000077;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;chromatin organization#GO:0006325;negative regulation of biosynthetic process#GO:0009890;DNA integrity checkpoint signaling#GO:0031570;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of cell cycle phase transition#GO:1901987;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;heterochromatin formation#GO:0031507;cellular response to stimulus#GO:0051716 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 histone modifying enzyme#PC00261;chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=4543|UniProtKB=P32298 P32298 GRK4 PTHR24355:SF14 G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE G PROTEIN-COUPLED RECEPTOR KINASE 4 transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;protein kinase activity#GO:0004672 regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GPRK#P00701;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GPRK#P00741 HUMAN|HGNC=32528|UniProtKB=Q00LT1 Q00LT1 PRCD PTHR38501:SF1 PHOTORECEPTOR DISK COMPONENT PRCD PHOTORECEPTOR DISK COMPONENT PRCD protein binding#GO:0005515;binding#GO:0005488 cell projection membrane#GO:0031253;membrane-bounded organelle#GO:0043227;non-motile cilium#GO:0097730;cilium#GO:0005929;organelle#GO:0043226;photoreceptor outer segment#GO:0001750;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;plasma membrane region#GO:0098590;plasma membrane#GO:0005886;ciliary membrane#GO:0060170;9+0 non-motile cilium#GO:0097731;membrane#GO:0016020;neuron projection#GO:0043005;photoreceptor cell cilium#GO:0097733;cell periphery#GO:0071944 HUMAN|HGNC=13199|UniProtKB=P98169 P98169 ZXDB PTHR46179:SF21 ZINC FINGER PROTEIN ZINC FINGER X-LINKED PROTEIN ZXDB transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HUMAN|HGNC=51508|UniProtKB=P0DUX1 P0DUX1 SPDYE12 PTHR31156:SF15 WBSCR19-LIKE PROTEIN SPEEDY PROTEIN E10-RELATED HUMAN|HGNC=18069|UniProtKB=Q9UHE5 Q9UHE5 NAT8 PTHR13947:SF48 GNAT FAMILY N-ACETYLTRANSFERASE N-ACETYLTRANSFERASE 8-RELATED N-acetyltransferase activity#GO:0008080;catalytic activity#GO:0003824;acetyltransferase activity#GO:0016407;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 acetyltransferase#PC00038 HUMAN|HGNC=28881|UniProtKB=Q8NI35 Q8NI35 PATJ PTHR19964:SF11 MULTIPLE PDZ DOMAIN PROTEIN INAD-LIKE PROTEIN cellular component assembly#GO:0022607;cell junction organization#GO:0034330;cell junction assembly#GO:0034329;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;cell-cell junction organization#GO:0045216;cell-cell junction assembly#GO:0007043 cell periphery#GO:0071944;membrane#GO:0016020;cell-cell junction#GO:0005911;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;bicellular tight junction#GO:0005923;apical part of cell#GO:0045177;apical junction complex#GO:0043296;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;tight junction#GO:0070160;cell junction#GO:0030054 scaffold/adaptor protein#PC00226 HUMAN|HGNC=5783|UniProtKB=A0A075B6P5 A0A075B6P5 IGKV2-28 PTHR23267:SF499 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN KAPPA VARIABLE 2-28-RELATED immune response#GO:0006955;immune system process#GO:0002376;response to stimulus#GO:0050896 protein-containing complex#GO:0032991 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=20301|UniProtKB=Q8IZD6 Q8IZD6 SLC22A15 PTHR24064:SF170 SOLUTE CARRIER FAMILY 22 MEMBER SOLUTE CARRIER FAMILY 22 MEMBER 15 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 transport#GO:0006810;cellular process#GO:0009987;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258 HUMAN|HGNC=12531|UniProtKB=Q9HAW8 Q9HAW8 UGT1A10 PTHR48050:SF6 STEROL 3-BETA-GLUCOSYLTRANSFERASE UDP-GLUCURONOSYLTRANSFERASE 1A10-RELATED molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;protein binding#GO:0005515;enzyme binding#GO:0019899;binding#GO:0005488;molecular function regulator activity#GO:0098772;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;enzyme inhibitor activity#GO:0004857;transferase activity#GO:0016740;catalytic activity#GO:0003824 hormone metabolic process#GO:0042445;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;pigment metabolic process#GO:0042440;sterol metabolic process#GO:0016125;developmental process#GO:0032502;lipid metabolic process#GO:0006629;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;anatomical structure development#GO:0048856;system development#GO:0048731;response to steroid hormone#GO:0048545;response to chemical#GO:0042221;response to lipid#GO:0033993;cellular response to lipid#GO:0071396;steroid metabolic process#GO:0008202;response to hormone#GO:0009725;cellular process#GO:0009987;multicellular organism development#GO:0007275;cellular response to steroid hormone stimulus#GO:0071383;animal organ development#GO:0048513;metabolic process#GO:0008152;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;cellular response to hormone stimulus#GO:0032870;liver development#GO:0001889;response to endogenous stimulus#GO:0009719;regulation of hormone levels#GO:0010817;estrogen metabolic process#GO:0008210;regulation of biological quality#GO:0065008;cellular response to chemical stimulus#GO:0070887;animal gross anatomical part developmental process#GO:0160108 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 glycosyltransferase#PC00111;transferase#PC00220 HUMAN|HGNC=14981|UniProtKB=P51003 P51003 PAPOLA PTHR10682:SF9 POLY A POLYMERASE POLY(A) POLYMERASE ALPHA transferase activity, transferring phosphorus-containing groups#GO:0016772;adenylyltransferase activity#GO:0070566;catalytic activity#GO:0003824;transferase activity#GO:0016740;nucleotidyltransferase activity#GO:0016779 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031;mRNA polyadenylation factor#PC00146 HUMAN|HGNC=4026|UniProtKB=P54710 P54710 FXYD2 PTHR14132:SF3 SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT GAMMA SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT GAMMA channel regulator activity#GO:0016247;molecular function regulator activity#GO:0098772;transporter regulator activity#GO:0141108;ion channel regulator activity#GO:0099106 regulation of monoatomic ion transmembrane transport#GO:0034765;regulation of biological process#GO:0050789;positive regulation of transport#GO:0051050;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of transmembrane transport#GO:0034762;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of metal ion transport#GO:0010959;regulation of monoatomic ion transport#GO:0043269;regulation of monoatomic cation transmembrane transport#GO:1904062;regulation of localization#GO:0032879;regulation of transport#GO:0051049 primary active transporter#PC00068;transporter#PC00227 HUMAN|HGNC=23|UniProtKB=P80404 P80404 ABAT PTHR43206:SF1 AMINOTRANSFERASE 4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL heterocyclic compound binding#GO:1901363;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;anion binding#GO:0043168 oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;amino acid metabolic process#GO:0006520;small molecule catabolic process#GO:0044282;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 metabolite interconversion enzyme#PC00262;transferase#PC00220;transaminase#PC00216 Pyrimidine Metabolism#P02771>Aminotransferase#P03129;Aminobutyrate degradation#P02726>4-aminobutyrate aminotransferase#P02825;Gamma-aminobutyric acid synthesis#P04384>GABA aminotransferase#P04480 HUMAN|HGNC=14542|UniProtKB=Q9Y3S1 Q9Y3S1 WNK2 PTHR13902:SF10 SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED SERINE_THREONINE-PROTEIN KINASE WNK2 catalytic activity, acting on a protein#GO:0140096;molecular function regulator activity#GO:0098772;transferase activity#GO:0016740;catalytic activity#GO:0003824;ion channel regulator activity#GO:0099106;ion channel inhibitor activity#GO:0008200;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773;channel regulator activity#GO:0016247;protein kinase activity#GO:0004672;molecular function inhibitor activity#GO:0140678;protein serine/threonine kinase activity#GO:0004674;transporter regulator activity#GO:0141108;potassium channel regulator activity#GO:0015459 negative regulation of biological process#GO:0048519;regulation of transmembrane transport#GO:0034762;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;negative regulation of transport#GO:0051051;regulation of metal ion transport#GO:0010959;regulation of cellular process#GO:0050794;signaling#GO:0023052;homeostatic process#GO:0042592;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;monoatomic ion homeostasis#GO:0050801;positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165;positive regulation of transport#GO:0051050;positive regulation of biological process#GO:0048518;regulation of monoatomic ion transmembrane transport#GO:0034765;cellular process#GO:0009987;regulation of monoatomic ion transport#GO:0043269;biological regulation#GO:0065007;regulation of monoatomic cation transmembrane transport#GO:1904062;chemical homeostasis#GO:0048878;regulation of transport#GO:0051049;regulation of localization#GO:0032879 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=24205|UniProtKB=Q96KX2 Q96KX2 CAPZA3 PTHR10653:SF6 F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA-3 protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;actin binding#GO:0003779;actin filament binding#GO:0051015;cytoskeletal protein binding#GO:0008092 regulation of protein depolymerization#GO:1901879;regulation of actin filament-based process#GO:0032970;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;regulation of actin polymerization or depolymerization#GO:0008064;negative regulation of protein depolymerization#GO:1901880;regulation of actin filament polymerization#GO:0030833;regulation of actin filament organization#GO:0110053;negative regulation of protein-containing complex assembly#GO:0031333;negative regulation of cytoskeleton organization#GO:0051494;negative regulation of protein-containing complex disassembly#GO:0043242;actin filament capping#GO:0051693;negative regulation of protein polymerization#GO:0032272;actin filament-based process#GO:0030029;regulation of actin filament depolymerization#GO:0030834;regulation of cytoskeleton organization#GO:0051493;regulation of protein polymerization#GO:0032271;negative regulation of supramolecular fiber organization#GO:1902904;regulation of cellular process#GO:0050794;actin cytoskeleton organization#GO:0030036;regulation of supramolecular fiber organization#GO:1902903;negative regulation of organelle organization#GO:0010639;negative regulation of cellular component organization#GO:0051129;cellular component organization or biogenesis#GO:0071840;regulation of anatomical structure size#GO:0090066;cytoskeleton organization#GO:0007010;regulation of actin cytoskeleton organization#GO:0032956;cellular process#GO:0009987;regulation of protein-containing complex disassembly#GO:0043244;organelle organization#GO:0006996;negative regulation of actin filament depolymerization#GO:0030835;regulation of biological quality#GO:0065008;regulation of actin filament length#GO:0030832;negative regulation of actin filament polymerization#GO:0030837;regulation of cellular component biogenesis#GO:0044087;regulation of cellular component organization#GO:0051128;regulation of biological process#GO:0050789;regulation of cellular component size#GO:0032535;regulation of organelle organization#GO:0033043;negative regulation of biological process#GO:0048519;regulation of protein-containing complex assembly#GO:0043254;cellular component organization#GO:0016043 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;cell periphery#GO:0071944;cell cortex#GO:0005938;cortical cytoskeleton#GO:0030863;actin cytoskeleton#GO:0015629;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 non-motor actin binding protein#PC00165 HUMAN|HGNC=24270|UniProtKB=Q9H2P9 Q9H2P9 DPH5 PTHR10882:SF0 DIPHTHINE SYNTHASE DIPHTHINE METHYL ESTER SYNTHASE methyltransferase#PC00155 HUMAN|HGNC=4642|UniProtKB=P0CG29 P0CG29 GSTT2 PTHR43917:SF4 FAMILY NOT NAMED GLUTATHIONE S-TRANSFERASE THETA-2-RELATED catalytic activity#GO:0003824;glutathione transferase activity#GO:0004364;transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765 cellular process#GO:0009987;metabolic process#GO:0008152;glutathione metabolic process#GO:0006749;modified amino acid metabolic process#GO:0006575;sulfur compound metabolic process#GO:0006790 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 transferase#PC00220 HUMAN|HGNC=13628|UniProtKB=Q8WXS5 Q8WXS5 CACNG8 PTHR12107:SF2 VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA SUBUNIT VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-8 SUBUNIT channel regulator activity#GO:0016247;channel activity#GO:0015267;voltage-gated calcium channel activity#GO:0005245;transporter regulator activity#GO:0141108;molecular function regulator activity#GO:0098772;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;passive transmembrane transporter activity#GO:0022803;calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215 positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regulation of trans-synaptic signaling#GO:0099177;regulation of postsynaptic membrane neurotransmitter receptor levels#GO:0099072;system process#GO:0003008;transmission of nerve impulse#GO:0019226;regulation of biological process#GO:0050789;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;localization within membrane#GO:0051668;nervous system process#GO:0050877;regulation of signaling#GO:0023051;positive regulation of synaptic transmission#GO:0050806;regulation of biological quality#GO:0065008;localization#GO:0051179;cell communication#GO:0007154;regulation of synaptic transmission, glutamatergic#GO:0051966;cellular localization#GO:0051641;positive regulation of signaling#GO:0023056 postsynaptic density membrane#GO:0098839;transmembrane transporter complex#GO:1902495;postsynaptic density#GO:0014069;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;organelle#GO:0043226;asymmetric synapse#GO:0032279;synapse#GO:0045202;cellular anatomical structure#GO:0110165;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;postsynapse#GO:0098794;cell junction#GO:0030054;transporter complex#GO:1990351;synaptic membrane#GO:0097060;signaling receptor complex#GO:0043235;plasma membrane#GO:0005886;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;neuron to neuron synapse#GO:0098984;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227;ion channel#PC00133;voltage-gated ion channel#PC00241 HUMAN|HGNC=27334|UniProtKB=Q5JSJ4 Q5JSJ4 INTS6L PTHR12957:SF22 DEAD/H BOX POLYPEPTIDE 26/DICE1-RELATED INTEGRATOR COMPLEX SUBUNIT 6-LIKE molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 snRNA 3'-end processing#GO:0034472;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;snRNA metabolic process#GO:0016073;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;snRNA processing#GO:0016180;RNA 3'-end processing#GO:0031123;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 integrator complex#GO:0032039;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 RNA helicase#PC00032 HUMAN|HGNC=30424|UniProtKB=Q8TCT6 Q8TCT6 SPPL3 PTHR12174:SF22 SIGNAL PEPTIDE PEPTIDASE SIGNAL PEPTIDE PEPTIDASE-LIKE 3 peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;aspartic-type endopeptidase activity#GO:0004190;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;membrane protein proteolysis#GO:0033619;cellular process#GO:0009987;metabolic process#GO:0008152;proteolysis#GO:0006508;primary metabolic process#GO:0044238 bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;cytoplasmic side of membrane#GO:0098562;endoplasmic reticulum#GO:0005783;Golgi-associated vesicle#GO:0005798;endoplasmic reticulum membrane#GO:0005789;cytoplasm#GO:0005737;cytoplasmic side of endoplasmic reticulum membrane#GO:0098554;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;vesicle membrane#GO:0012506;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;side of membrane#GO:0098552;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;Golgi-associated vesicle membrane#GO:0030660;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708 aspartic protease#PC00053;protein modifying enzyme#PC00260 HUMAN|HGNC=34332|UniProtKB=Q9Y2P0 Q9Y2P0 ZNF835 PTHR24404:SF129 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 835 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 DNA-binding transcription factor#PC00218;C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HUMAN|HGNC=30866|UniProtKB=Q8IX04 Q8IX04 UEVLD PTHR23306:SF18 TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED UBIQUITIN-CONJUGATING ENZYME E2 VARIANT 3 binding#GO:0005488;ubiquitin binding#GO:0043130;protein binding#GO:0005515 cellular process#GO:0009987;transport#GO:0006810;localization#GO:0051179;vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;vesicle#GO:0031982;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endosome membrane#GO:0010008;endosome#GO:0005768;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;cytoplasm#GO:0005737;vesicle membrane#GO:0012506;ESCRT I complex#GO:0000813;membrane#GO:0016020;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=31455|UniProtKB=Q5JTZ5 Q5JTZ5 C9orf152 PTHR36290:SF1 RIKEN CDNA D630039A03 GENE RIKEN CDNA D630039A03 GENE HUMAN|HGNC=4371|UniProtKB=Q9UKD1 Q9UKD1 GMEB2 PTHR10417:SF2 GLUCOCORTICOID MODULATORY ELEMENT-BINDING PROTEIN GLUCOCORTICOID MODULATORY ELEMENT-BINDING PROTEIN 2 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;DNA-binding transcription activator activity#GO:0001216;transcription regulator activity#GO:0140110;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;sequence-specific DNA binding#GO:0043565 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=23018|UniProtKB=Q6UE05 Q6UE05 TMEM270 PTHR37369:SF1 TRANSMEMBRANE PROTEIN 270 TRANSMEMBRANE PROTEIN 270 HUMAN|HGNC=29027|UniProtKB=O43149 O43149 ZZEF1 PTHR22772:SF4 NOVEL ZZ TYPE ZINC FINGER DOMAIN CONTAINING PROTEIN ZINC FINGER ZZ-TYPE AND EF-HAND DOMAIN-CONTAINING PROTEIN 1 HUMAN|HGNC=7105|UniProtKB=O75030 O75030 MITF PTHR45776:SF4 MIP04163P MICROPHTHALMIA-ASSOCIATED TRANSCRIPTION FACTOR DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;pigmentation#GO:0043473;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of biological process#GO:0050789;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;melanocyte differentiation#GO:0030318;developmental pigmentation#GO:0048066;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=18711|UniProtKB=Q8N145 Q8N145 LGI3 PTHR24367:SF10 LEUCINE-RICH REPEAT-CONTAINING PROTEIN LEUCINE-RICH REPEAT LGI FAMILY MEMBER 3 regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of secretion#GO:0051046;regulation of localization#GO:0032879;regulation of transport#GO:0051049;regulation of exocytosis#GO:0017157;regulation of secretion by cell#GO:1903530 transport vesicle#GO:0030133;endomembrane system#GO:0012505;cytoplasm#GO:0005737;secretory vesicle#GO:0099503;presynapse#GO:0098793;cell junction#GO:0030054;organelle#GO:0043226;cellular anatomical structure#GO:0110165;synapse#GO:0045202;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;synaptic vesicle#GO:0008021;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382 HUMAN|HGNC=30770|UniProtKB=Q8N6N6 Q8N6N6 NATD1 PTHR31435:SF9 PROTEIN NATD1 PROTEIN NATD1 HUMAN|HGNC=20399|UniProtKB=Q9NYZ1 Q9NYZ1 TVP23B PTHR13019:SF9 GOLGI APPARATUS MEMBRANE PROTEIN TVP23 GOLGI APPARATUS MEMBRANE PROTEIN TVP23 HOMOLOG B macromolecule localization#GO:0033036;protein localization to extracellular region#GO:0071692;cellular process#GO:0009987;establishment of protein localization#GO:0045184;vesicle-mediated transport#GO:0016192;export from cell#GO:0140352;transport#GO:0006810;establishment of localization#GO:0051234;secretion#GO:0046903;protein secretion#GO:0009306;localization#GO:0051179;establishment of protein localization to extracellular region#GO:0035592;protein transport#GO:0015031;intracellular protein localization#GO:0008104;secretion by cell#GO:0032940 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139 HUMAN|HGNC=25536|UniProtKB=Q5D0E6 Q5D0E6 DALRD3 PTHR16043:SF1 DALRD3 PROTEIN DALR ANTICODON-BINDING DOMAIN-CONTAINING PROTEIN 3 nucleic acid binding#GO:0003676;binding#GO:0005488;tRNA binding#GO:0000049;RNA binding#GO:0003723 macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;tRNA methylation#GO:0030488;RNA methylation#GO:0001510;macromolecule modification#GO:0043412;methylation#GO:0032259;RNA metabolic process#GO:0016070;macromolecule methylation#GO:0043414;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;RNA biosynthetic process#GO:0032774;tRNA modification#GO:0006400;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 HUMAN|HGNC=20818|UniProtKB=Q8TF66 Q8TF66 LRRC15 PTHR24373:SF262 SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN LEUCINE-RICH REPEAT-CONTAINING PROTEIN 15 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=11924|UniProtKB=Q07011 Q07011 TNFRSF9 PTHR47139:SF1 TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 9 TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 9 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 biological regulation#GO:0065007;regulation of cell population proliferation#GO:0042127;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789 transmembrane signal receptor#PC00197 HUMAN|HGNC=4977|UniProtKB=Q16534 Q16534 HLF PTHR11988:SF28 THYROTROPH EMBRYONIC FACTOR RELATED HEPATIC LEUKEMIA FACTOR sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of transcription by RNA polymerase II#GO:0045944;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;basic leucine zipper transcription factor#PC00056 HUMAN|HGNC=14644|UniProtKB=Q8NC67 Q8NC67 NETO2 PTHR24251:SF26 OVOCHYMASE-RELATED NEUROPILIN AND TOLLOID-LIKE PROTEIN 2 signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515 protein localization to synapse#GO:0035418;regulation of localization#GO:0032879;intracellular protein localization#GO:0008104;protein localization to cell periphery#GO:1990778;regulation of postsynaptic membrane neurotransmitter receptor levels#GO:0099072;biological regulation#GO:0065007;macromolecule localization#GO:0033036;regulation of protein localization to membrane#GO:1905475;cellular process#GO:0009987;localization#GO:0051179;cellular localization#GO:0051641;regulation of protein localization#GO:0032880;regulation of biological quality#GO:0065008;protein localization to cell junction#GO:1902414;localization within membrane#GO:0051668;regulation of cellular process#GO:0050794;protein localization to organelle#GO:0033365;protein localization to membrane#GO:0072657;regulation of biological process#GO:0050789 postsynaptic density membrane#GO:0098839;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;postsynaptic density#GO:0014069;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;asymmetric synapse#GO:0032279;postsynapse#GO:0098794;cell junction#GO:0030054;synaptic membrane#GO:0097060;neuron to neuron synapse#GO:0098984;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 protease#PC00190;serine protease#PC00203 HUMAN|HGNC=25886|UniProtKB=Q6NZ67 Q6NZ67 MZT2B PTHR28578:SF4 MITOTIC-SPINDLE ORGANIZING PROTEIN 2A-RELATED MITOTIC-SPINDLE ORGANIZING PROTEIN 2B intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;spindle#GO:0005819;centrosome#GO:0005813;microtubule organizing center#GO:0005815;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=25812|UniProtKB=Q9H8P0 Q9H8P0 SRD5A3 PTHR14624:SF0 DFG10 PROTEIN POLYPRENAL REDUCTASE oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;catalytic activity#GO:0003824 glycoprotein biosynthetic process#GO:0009101;organophosphate metabolic process#GO:0019637;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;lipid metabolic process#GO:0006629;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487;phospholipid biosynthetic process#GO:0008654;phospholipid metabolic process#GO:0006644;organophosphate biosynthetic process#GO:0090407;protein metabolic process#GO:0019538 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=9977|UniProtKB=O75677 O75677 RFPL1 PTHR24103:SF657 E3 UBIQUITIN-PROTEIN LIGASE TRIM RET FINGER PROTEIN-LIKE 1-RELATED acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 defense response to symbiont#GO:0140546;immune response#GO:0006955;response to stress#GO:0006950;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;response to biotic stimulus#GO:0009607;response to other organism#GO:0051707;biological regulation#GO:0065007;defense response to other organism#GO:0098542;defense response#GO:0006952;regulation of gene expression#GO:0010468;response to external stimulus#GO:0009605;innate immune response#GO:0045087;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;immune system process#GO:0002376 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=9438|UniProtKB=O75569 O75569 PRKRA PTHR46205:SF2 LOQUACIOUS, ISOFORM B INTERFERON-INDUCIBLE DOUBLE-STRANDED RNA-DEPENDENT PROTEIN KINASE ACTIVATOR A binding#GO:0005488;nucleic acid binding#GO:0003676;double-stranded RNA binding#GO:0003725;RNA binding#GO:0003723 negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;siRNA processing#GO:0030422;regulation of biological process#GO:0050789;regulation of gene silencing by regulatory ncRNA#GO:0060966;negative regulation of metabolic process#GO:0009892;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;RNA biosynthetic process#GO:0032774;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;macromolecule biosynthetic process#GO:0009059;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of biosynthetic process#GO:0009890;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;regulatory ncRNA-mediated gene silencing#GO:0031047;regulation of biosynthetic process#GO:0009889;regulatory ncRNA processing#GO:0070918;macromolecule metabolic process#GO:0043170;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;endonuclease complex#GO:1905348;endoribonuclease complex#GO:1902555;ribonucleoprotein complex#GO:1990904;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 Apoptosis signaling pathway#P00006>PACT#P00280 HUMAN|HGNC=28172|UniProtKB=Q96B23 Q96B23 ARK2N PTHR16200:SF5 RING ZINC FINGER PROTEIN ARK2N ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824 ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;catabolic process#GO:0009056;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=8828|UniProtKB=Q9HAT8 Q9HAT8 PELI2 PTHR12098:SF5 E3 UBIQUITIN-PROTEIN LIGASE PELLINO-RELATED E3 UBIQUITIN-PROTEIN LIGASE PELLINO HOMOLOG 2 catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842 cellular process#GO:0009987;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;protein modification process#GO:0036211;primary metabolic process#GO:0044238;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=4388|UniProtKB=P38405 P38405 GNAL PTHR10218:SF233 GTP-BINDING PROTEIN ALPHA SUBUNIT GUANINE NUCLEOTIDE-BINDING PROTEIN G(OLF) SUBUNIT ALPHA molecular function regulator activity#GO:0098772;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818 regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;sensory perception#GO:0007600;response to oxygen-containing compound#GO:1901700;nervous system process#GO:0050877;cell communication#GO:0007154;response to nitrogen compound#GO:1901698;G protein-coupled dopamine receptor signaling pathway#GO:0007212;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;cellular process#GO:0009987;response to chemical#GO:0042221;cellular response to nitrogen compound#GO:1901699;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;sensory perception of chemical stimulus#GO:0007606;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;system process#GO:0003008 cytoplasmic side of membrane#GO:0098562;extrinsic component of membrane#GO:0019898;extrinsic component of plasma membrane#GO:0019897;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;extrinsic component of cytoplasmic side of plasma membrane#GO:0031234;intracellular anatomical structure#GO:0005622;side of membrane#GO:0098552;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;cytoplasmic side of plasma membrane#GO:0009898;cellular anatomical structure#GO:0110165 heterotrimeric G-protein#PC00117;G-protein#PC00020 Beta2 adrenergic receptor signaling pathway#P04378>G-Protein#P04443;5HT4 type receptor mediated signaling pathway#P04376>G-protein#P04430;Histamine H2 receptor mediated signaling pathway#P04386>G-Protein#P04490;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Gsalpha#P00705;Cortocotropin releasing factor receptor signaling pathway#P04380>G-Protein#P04458;Beta3 adrenergic receptor signaling pathway#P04379>G-Protein#P04448;Beta1 adrenergic receptor signaling pathway#P04377>G-Protein#P04436;Endothelin signaling pathway#P00019>Gs#P00584;Enkephalin release#P05913>G-Protein (s)#P05977 HUMAN|HGNC=28534|UniProtKB=Q8N5N4 Q8N5N4 C3orf22 PTHR37875:SF1 HYPOTHETICAL PROTEIN LOC685964 SIMILAR TO HUMAN CHROMOSOME 3 OPEN READING FRAME 22 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=26064|UniProtKB=Q969Z3 Q969Z3 MTARC2 PTHR14237:SF27 MOLYBDOPTERIN COFACTOR SULFURASE MOSC MITOCHONDRIAL AMIDOXIME REDUCING COMPONENT 2 oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;cation binding#GO:0043169;metal ion binding#GO:0046872;transition metal ion binding#GO:0046914;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167 small molecule metabolic process#GO:0044281;nitrate metabolic process#GO:0042126;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;cellular process#GO:0009987 HUMAN|HGNC=24764|UniProtKB=Q2TAL5 Q2TAL5 SMTNL2 PTHR23167:SF37 CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED SMOOTHELIN-LIKE PROTEIN 2 cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996 scaffold/adaptor protein#PC00226 HUMAN|HGNC=3039|UniProtKB=O60469 O60469 DSCAM PTHR10075:SF51 BASIGIN RELATED CELL ADHESION MOLECULE DSCAM cellular component organization#GO:0016043;regulation of chemotaxis#GO:0050920;positive regulation of multicellular organismal process#GO:0051240;regulation of multicellular organismal development#GO:2000026;regulation of biological process#GO:0050789;regulation of cellular component size#GO:0032535;central nervous system development#GO:0007417;positive regulation of nervous system development#GO:0051962;regulation of cellular component organization#GO:0051128;positive regulation of growth#GO:0045927;animal gross anatomical part developmental process#GO:0160108;positive regulation of cellular component organization#GO:0051130;regulation of cell size#GO:0008361;regulation of biological quality#GO:0065008;positive regulation of axonogenesis#GO:0050772;cellular process#GO:0009987;regulation of neuron projection development#GO:0010975;positive regulation of biological process#GO:0048518;regulation of response to external stimulus#GO:0032101;regulation of cell growth#GO:0001558;nervous system development#GO:0007399;positive regulation of cell development#GO:0010720;regulation of multicellular organismal process#GO:0051239;regulation of anatomical structure size#GO:0090066;positive regulation of cell differentiation#GO:0045597;positive regulation of response to external stimulus#GO:0032103;regulation of anatomical structure morphogenesis#GO:0022603;positive regulation of cell growth#GO:0030307;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;regulation of axonogenesis#GO:0050770;regulation of neurogenesis#GO:0050767;regulation of growth#GO:0040008;regulation of cellular process#GO:0050794;positive regulation of neurogenesis#GO:0050769;regulation of developmental process#GO:0050793;positive regulation of cell projection organization#GO:0031346;positive regulation of chemotaxis#GO:0050921;anatomical structure development#GO:0048856;regulation of nervous system development#GO:0051960;system development#GO:0048731;regulation of cell development#GO:0060284;positive regulation of cellular process#GO:0048522;multicellular organismal process#GO:0032501;positive regulation of response to stimulus#GO:0048584;regulation of locomotion#GO:0040012;biological regulation#GO:0065007;regulation of cell projection organization#GO:0031344;regulation of cell differentiation#GO:0045595;regulation of response to stimulus#GO:0048583;developmental process#GO:0032502;positive regulation of developmental process#GO:0051094;regulation of plasma membrane bounded cell projection organization#GO:0120035;positive regulation of locomotion#GO:0040017 cellular anatomical structure#GO:0110165;neuronal cell body#GO:0043025;somatodendritic compartment#GO:0036477;cell body#GO:0044297 cell adhesion molecule#PC00069 HUMAN|HGNC=25159|UniProtKB=A0PJX4 A0PJX4 SHISA3 PTHR31395:SF4 SHISA PROTEIN SHISA-3 HOMOLOG scaffold/adaptor protein#PC00226 HUMAN|HGNC=29217|UniProtKB=Q9ULL5 Q9ULL5 PRR12 PTHR14709:SF1 GLUTAMINE AND SERINE-RICH PROTEIN 1-RELATED PROLINE-RICH PROTEIN 12 HUMAN|HGNC=26350|UniProtKB=Q7Z5J8 Q7Z5J8 ANKAR PTHR46464:SF1 ANK_REP_REGION DOMAIN-CONTAINING PROTEIN ANKYRIN AND ARMADILLO REPEAT-CONTAINING PROTEIN HUMAN|HGNC=17847|UniProtKB=Q15208 Q15208 STK38 PTHR24356:SF221 SERINE/THREONINE-PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE 38 phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;establishment or maintenance of cell polarity#GO:0007163 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=11926|UniProtKB=O14788 O14788 TNFSF11 PTHR11471:SF3 TUMOR NECROSIS FACTOR FAMILY MEMBER TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 11 receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;cytokine activity#GO:0005125;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677 regulation of apoptotic process#GO:0042981;cell surface receptor signaling pathway#GO:0007166;positive regulation of cell differentiation#GO:0045597;positive regulation of canonical NF-kappaB signal transduction#GO:0043123;positive regulation of apoptotic process#GO:0043065;positive regulation of immune system process#GO:0002684;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of cell development#GO:0010720;regulation of multicellular organismal process#GO:0051239;regulation of intracellular signal transduction#GO:1902531;regulation of myeloid cell differentiation#GO:0045637;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;regulation of programmed cell death#GO:0043067;regulation of multicellular organismal development#GO:2000026;positive regulation of multicellular organismal process#GO:0051240;regulation of biological process#GO:0050789;positive regulation of programmed cell death#GO:0043068;response to stimulus#GO:0050896;signaling#GO:0023052;regulation of response to stimulus#GO:0048583;regulation of cell differentiation#GO:0045595;positive regulation of developmental process#GO:0051094;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of extrinsic apoptotic signaling pathway#GO:2001238;regulation of cell development#GO:0060284;regulation of canonical NF-kappaB signal transduction#GO:0043122;positive regulation of myeloid cell differentiation#GO:0045639;positive regulation of cellular process#GO:0048522;positive regulation of response to stimulus#GO:0048584;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of apoptotic signaling pathway#GO:2001233;cell communication#GO:0007154;regulation of hemopoiesis#GO:1903706;positive regulation of signal transduction#GO:0009967;regulation of extrinsic apoptotic signaling pathway#GO:2001236;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of immune system process#GO:0002682;regulation of cell communication#GO:0010646;positive regulation of apoptotic signaling pathway#GO:2001235;regulation of developmental process#GO:0050793 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HUMAN|HGNC=7046|UniProtKB=Q09327 Q09327 MGAT3 PTHR12224:SF0 BETA-1,4-MANNOSYL-GLYCOPROTEIN BETA-1,4-N-ACETYLGLUCOSAMINYL-TRANSFERASE BETA-1,4-MANNOSYL-GLYCOPROTEIN 4-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE glycosyltransferase activity#GO:0016757;transferase activity#GO:0016740;catalytic activity#GO:0003824 carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;metabolic process#GO:0008152;amino sugar metabolic process#GO:0006040 glycosyltransferase#PC00111;transferase#PC00220 HUMAN|HGNC=6931|UniProtKB=P41968 P41968 MC3R PTHR22750:SF4 G-PROTEIN COUPLED RECEPTOR MELANOCORTIN RECEPTOR 3 hormone binding#GO:0042562;signaling receptor activity#GO:0038023;peptide hormone binding#GO:0017046;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;binding#GO:0005488;molecular transducer activity#GO:0060089 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cell communication#GO:0007154 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021 HUMAN|HGNC=9752|UniProtKB=P09417 P09417 QDPR PTHR15104:SF0 DIHYDROPTERIDINE REDUCTASE DIHYDROPTERIDINE REDUCTASE nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167;binding#GO:0005488;anion binding#GO:0043168;small molecule binding#GO:0036094;catalytic activity#GO:0003824;purine nucleotide binding#GO:0017076;heterocyclic compound binding#GO:1901363;oxidoreductase activity#GO:0016491;nucleotide binding#GO:0000166 metabolic process#GO:0008152;alcohol metabolic process#GO:0006066;small molecule biosynthetic process#GO:0044283;small molecule metabolic process#GO:0044281;pteridine-containing compound metabolic process#GO:0042558;biosynthetic process#GO:0009058;alcohol biosynthetic process#GO:0046165;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 oxidoreductase#PC00176;reductase#PC00198 HUMAN|HGNC=2682|UniProtKB=Q9NQZ3 Q9NQZ3 DAZ1 PTHR11176:SF8 BOULE-RELATED DELETED IN AZOOSPERMIA PROTEIN 1-RELATED translation regulator activity#GO:0045182 regulation of biological quality#GO:0065008;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;RNA stabilization#GO:0043489;regulation of translational initiation#GO:0006446;positive regulation of protein metabolic process#GO:0051247;negative regulation of metabolic process#GO:0009892;regulation of mRNA stability#GO:0043488;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;regulation of mRNA metabolic process#GO:1903311;negative regulation of RNA metabolic process#GO:0051253;mRNA stabilization#GO:0048255;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;regulation of protein metabolic process#GO:0051246;negative regulation of catabolic process#GO:0009895;positive regulation of translation#GO:0045727;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;regulation of RNA stability#GO:0043487;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of gene expression#GO:0010628;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA catabolic process#GO:1902369;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HUMAN|HGNC=3387|UniProtKB=P29320 P29320 EPHA3 PTHR46877:SF12 EPH RECEPTOR A5 EPHRIN TYPE-A RECEPTOR 3 phosphotransferase activity, alcohol group as acceptor#GO:0016773;molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714;protein kinase activity#GO:0004672;transmembrane signaling receptor activity#GO:0004888;catalytic activity, acting on a protein#GO:0140096;signaling receptor activity#GO:0038023;transmembrane receptor protein kinase activity#GO:0019199;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 neurogenesis#GO:0022008;neuron projection guidance#GO:0097485;cellular developmental process#GO:0048869;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;axon guidance#GO:0007411;axon development#GO:0061564;system development#GO:0048731;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;cell communication#GO:0007154;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of cellular process#GO:0050794;ephrin receptor signaling pathway#GO:0048013;cellular response to stimulus#GO:0051716;cell projection morphogenesis#GO:0048858;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cell surface receptor signaling pathway#GO:0007166;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;cellular process#GO:0009987;signal transduction#GO:0007165;neuron projection development#GO:0031175;neuron development#GO:0048666;axonogenesis#GO:0007409;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;signaling#GO:0023052;cell morphogenesis#GO:0000902;cell differentiation#GO:0030154;response to stimulus#GO:0050896;cell projection organization#GO:0030030;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;dendrite#GO:0030425;dendritic tree#GO:0097447 transmembrane signal receptor#PC00197 Angiogenesis#P00005>EphR#P00212 HUMAN|HGNC=11816|UniProtKB=Q9Y5L4 Q9Y5L4 TIMM13 PTHR19338:SF107 TRANSLOCASE OF INNER MITOCHONDRIAL MEMBRANE 13 HOMOLOG MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM13 cellular localization#GO:0051641;localization#GO:0051179;mitochondrial transport#GO:0006839;cellular component organization#GO:0016043;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;transport#GO:0006810;intracellular transport#GO:0046907;mitochondrion organization#GO:0007005;protein insertion into mitochondrial inner membrane#GO:0045039;mitochondrial protein import pathway#GO:7770058;membrane organization#GO:0061024;inner mitochondrial membrane organization#GO:0007007;cellular process#GO:0009987;mitochondrial membrane organization#GO:0007006;establishment of localization in cell#GO:0051649;organelle organization#GO:0006996 membrane-enclosed lumen#GO:0031974;mitochondrial envelope#GO:0005740;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;mitochondrial intermembrane space#GO:0005758;organelle envelope#GO:0031967;organelle lumen#GO:0043233;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=251|UniProtKB=P00326 P00326 ADH1C PTHR43880:SF57 ALCOHOL DEHYDROGENASE ALCOHOL DEHYDROGENASE 1C all-trans-retinol dehydrogenase (NAD+) activity#GO:0004745;cation binding#GO:0043169;metal ion binding#GO:0046872;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;transition metal ion binding#GO:0046914;small molecule binding#GO:0036094;binding#GO:0005488;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;ion binding#GO:0043167;alcohol dehydrogenase (NAD+) activity#GO:0004022;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;zinc ion binding#GO:0008270 metabolic process#GO:0008152;alcohol metabolic process#GO:0006066;detoxification#GO:0098754;cellular response to toxic substance#GO:0097237;response to chemical#GO:0042221;cellular response to oxygen-containing compound#GO:1901701;aldehyde metabolic process#GO:0006081;cellular process#GO:0009987;regulation of biological quality#GO:0065008;response to oxygen-containing compound#GO:1901700;cellular detoxification#GO:1990748;cellular response to chemical stimulus#GO:0070887;oxoacid metabolic process#GO:0043436;olefinic compound metabolic process#GO:0120254;small molecule catabolic process#GO:0044282;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;regulation of hormone levels#GO:0010817;monocarboxylic acid metabolic process#GO:0032787;cellular detoxification of aldehyde#GO:0110095;carboxylic acid metabolic process#GO:0019752;diterpenoid metabolic process#GO:0016101;retinoid metabolic process#GO:0001523;lipid metabolic process#GO:0006629;biological regulation#GO:0065007;aldehyde catabolic process#GO:0046185;hormone metabolic process#GO:0042445;isoprenoid metabolic process#GO:0006720;terpenoid metabolic process#GO:0006721;retinol metabolic process#GO:0042572;catabolic process#GO:0009056;response to toxic substance#GO:0009636;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 dehydrogenase#PC00092 HUMAN|HGNC=10048|UniProtKB=Q93091 Q93091 RNASE6 PTHR11437:SF4 RIBONUCLEASE RIBONUCLEASE K6 nuclease activity#GO:0004518;RNA nuclease activity#GO:0004540;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 antimicrobial humoral response#GO:0019730;humoral immune response#GO:0006959;defense response#GO:0006952;response to external stimulus#GO:0009605;innate immune response#GO:0045087;antibacterial humoral response#GO:0019731;defense response to symbiont#GO:0140546;immune response#GO:0006955;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;response to other organism#GO:0051707;defense response to other organism#GO:0098542;defense response to bacterium#GO:0042742;immune system process#GO:0002376;response to bacterium#GO:0009617;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;defense response to Gram-positive bacterium#GO:0050830;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;defense response to Gram-negative bacterium#GO:0050829;response to stimulus#GO:0050896 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 endoribonuclease#PC00094;RNA metabolism protein#PC00031 HUMAN|HGNC=11151|UniProtKB=P09012 P09012 SNRPA PTHR10501:SF63 U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A snRNA binding#GO:0017069;RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;U1 snRNP#GO:0005685;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;small nuclear ribonucleoprotein complex#GO:0030532;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;spliceosomal snRNP complex#GO:0097525;nuclear protein-containing complex#GO:0140513;Sm-like protein family complex#GO:0120114;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904 RNA processing factor#PC00147;RNA metabolism protein#PC00031;RNA splicing factor#PC00148 mRNA splicing#P00058>U1#P01479 HUMAN|HGNC=25180|UniProtKB=Q0JRZ9 Q0JRZ9 FCHO2 PTHR23065:SF8 PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1 F-BAR DOMAIN ONLY PROTEIN 2 localization#GO:0051179;cellular localization#GO:0051641;synaptic vesicle endocytosis#GO:0048488;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;clathrin-dependent endocytosis#GO:0072583;endocytosis#GO:0006897;transport#GO:0006810;synaptic vesicle cycle#GO:0099504;cellular component organization or biogenesis#GO:0071840;import into cell#GO:0098657;establishment of localization#GO:0051234;vesicle-mediated transport in synapse#GO:0099003;receptor-mediated endocytosis#GO:0006898;protein-containing complex organization#GO:0043933;cellular component biogenesis#GO:0044085;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;cellular component assembly#GO:0022607;vesicle-mediated transport#GO:0016192;synaptic vesicle recycling#GO:0036465 intracellular organelle#GO:0043229;coated vesicle#GO:0030135;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;clathrin-coated pit#GO:0005905;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;clathrin-coated vesicle#GO:0030136;membrane#GO:0016020;cell periphery#GO:0071944;endomembrane system#GO:0012505;cytoplasm#GO:0005737;plasma membrane#GO:0005886 cytoskeletal protein#PC00085;actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=29239|UniProtKB=Q9ULD6 Q9ULD6 INTU PTHR21082:SF4 PROTEIN INTURNED PROTEIN INTURNED multicellular organismal process#GO:0032501;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;nervous system development#GO:0007399;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cell projection assembly#GO:0030031;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection assembly#GO:0120031;developmental process#GO:0032502;cell projection organization#GO:0030030;cellular component organization#GO:0016043;cilium assembly#GO:0060271;anatomical structure development#GO:0048856;cilium organization#GO:0044782;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;organelle assembly#GO:0070925 cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cilium#GO:0005929 HUMAN|HGNC=6173|UniProtKB=O43736 O43736 ITM2A PTHR10962:SF7 INTEGRAL TRANSMEMBRANE PROTEIN 2 INTEGRAL MEMBRANE PROTEIN 2A peptide binding#GO:0042277;binding#GO:0005488 negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;negative regulation of cellular process#GO:0048523;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007 plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cell periphery#GO:0071944;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794 HUMAN|HGNC=18791|UniProtKB=Q9NU63 Q9NU63 ZFP57 PTHR24381:SF277 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 57 HOMOLOG sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=27022|UniProtKB=Q8TCW7 Q8TCW7 ZPLD1 PTHR14002:SF24 ENDOGLIN/TGF-BETA RECEPTOR TYPE III ZONA PELLUCIDA-LIKE DOMAIN-CONTAINING PROTEIN 1 cell surface#GO:0009986;cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 transmembrane signal receptor#PC00197 HUMAN|HGNC=28967|UniProtKB=Q14146 Q14146 URB2 PTHR15682:SF2 UNHEALTHY RIBOSOME BIOGENESIS PROTEIN 2 HOMOLOG UNHEALTHY RIBOSOME BIOGENESIS PROTEIN 2 HOMOLOG cellular component organization or biogenesis#GO:0071840;ribonucleoprotein complex biogenesis#GO:0022613;cellular component biogenesis#GO:0044085;ribosome biogenesis#GO:0042254;cellular process#GO:0009987 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233 HUMAN|HGNC=20291|UniProtKB=Q86XN7 Q86XN7 PROSER1 PTHR14880:SF2 PROLINE AND SERINE-RICH PROTEIN 1 PROLINE AND SERINE-RICH PROTEIN 1 HUMAN|HGNC=8702|UniProtKB=Q9Y5G9 Q9Y5G9 PCDHGA4 PTHR24028:SF94 CADHERIN-87A PROTOCADHERIN GAMMA-A4 cellular process#GO:0009987;cell adhesion#GO:0007155 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 cadherin#PC00057;cell adhesion molecule#PC00069 HUMAN|HGNC=28273|UniProtKB=Q96A09 Q96A09 TENT5B PTHR12974:SF46 PRION-LIKE- Q/N-RICH -DOMAIN-BEARING PROTEIN PROTEIN 44 TERMINAL NUCLEOTIDYLTRANSFERASE 5B transferase activity, transferring phosphorus-containing groups#GO:0016772;adenylyltransferase activity#GO:0070566;catalytic activity#GO:0003824;transferase activity#GO:0016740;nucleotidyltransferase activity#GO:0016779 regulation of mRNA metabolic process#GO:1903311;negative regulation of RNA metabolic process#GO:0051253;mRNA stabilization#GO:0048255;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of biological quality#GO:0065008;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;RNA stabilization#GO:0043489;negative regulation of metabolic process#GO:0009892;regulation of mRNA stability#GO:0043488;regulation of biological process#GO:0050789;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;positive regulation of gene expression#GO:0010628;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA catabolic process#GO:1902369;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of catabolic process#GO:0009895;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;regulation of RNA stability#GO:0043487;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 HUMAN|HGNC=9883|UniProtKB=P50749 P50749 RASSF2 PTHR22738:SF14 RASSF RAS ASSOCIATION DOMAIN-CONTAINING PROTEIN 2 regulation of response to stimulus#GO:0048583;regulation of MAPK cascade#GO:0043408;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of MAPK cascade#GO:0043410;regulation of JNK cascade#GO:0046328;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of response to stimulus#GO:0048584;regulation of signaling#GO:0023051;positive regulation of JNK cascade#GO:0046330;regulation of intracellular signal transduction#GO:1902531;positive regulation of signaling#GO:0023056;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of non-canonical NF-kappaB signal transduction#GO:1901222;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;signaling#GO:0023052;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;response to stimulus#GO:0050896 nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HUMAN|HGNC=16695|UniProtKB=P51572 P51572 BCAP31 PTHR12701:SF15 BCR-ASSOCIATED PROTEIN, BAP B-CELL RECEPTOR-ASSOCIATED PROTEIN 31 ATP-dependent activity#GO:0140657;molecular carrier activity#GO:0140104;protein carrier activity#GO:0140597 regulation of biological process#GO:0050789;response to stimulus#GO:0050896;positive regulation of protein metabolic process#GO:0051247;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;positive regulation of metabolic process#GO:0009893;protein transport#GO:0015031;regulation of protein metabolic process#GO:0051246;response to stress#GO:0006950;cellular process#GO:0009987;establishment of protein localization#GO:0045184;positive regulation of biological process#GO:0048518;response to chemical#GO:0042221;positive regulation of macromolecule metabolic process#GO:0010604;proteasomal protein catabolic process#GO:0010498;macromolecule catabolic process#GO:0009057;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;metabolic process#GO:0008152;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;positive regulation of ubiquitin-dependent protein catabolic process#GO:2000060;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;response to endoplasmic reticulum stress#GO:0034976;protein metabolic process#GO:0019538;localization#GO:0051179;regulation of protein catabolic process#GO:0042176;positive regulation of protein catabolic process#GO:0045732;ERAD pathway#GO:0036503;regulation of metabolic process#GO:0019222;macromolecule localization#GO:0033036;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;biological regulation#GO:0065007;transport#GO:0006810;positive regulation of catabolic process#GO:0009896;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;regulation of catabolic process#GO:0009894;intracellular protein localization#GO:0008104 endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 membrane traffic protein#PC00150 HUMAN|HGNC=6532|UniProtKB=Q86U70 Q86U70 LDB1 PTHR10378:SF7 LIM DOMAIN-BINDING PROTEIN LIM DOMAIN-BINDING PROTEIN 1 transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 negative regulation of macromolecule biosynthetic process#GO:0010558;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604;nervous system development#GO:0007399;positive regulation of transcription by RNA polymerase II#GO:0045944;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;multicellular organism development#GO:0007275;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;animal gross anatomical part developmental process#GO:0160108;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of RNA biosynthetic process#GO:1902680;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biosynthetic process#GO:0009891;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;system development#GO:0048731;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 Gonadotropin-releasing hormone receptor pathway#P06664>CLIM2#P06736 HUMAN|HGNC=28408|UniProtKB=Q8IZ02 Q8IZ02 LRRC34 PTHR24111:SF6 LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34 LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34 telomere organization#GO:0032200;chromosome organization#GO:0051276;telomere maintenance#GO:0000723;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;organelle organization#GO:0006996;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043 HUMAN|HGNC=6375|UniProtKB=P26717 P26717 KLRC2 PTHR22800:SF247 C-TYPE LECTIN PROTEINS NKG2-C TYPE II INTEGRAL MEMBRANE PROTEIN transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;immune receptor activity#GO:0140375;molecular transducer activity#GO:0060089 regulation of defense response#GO:0031347;regulation of immune response#GO:0050776;regulation of leukocyte mediated cytotoxicity#GO:0001910;regulation of immune effector process#GO:0002697;cell communication#GO:0007154;positive regulation of lymphocyte mediated immunity#GO:0002708;cellular response to stimulus#GO:0051716;regulation of natural killer cell mediated immunity#GO:0002715;regulation of leukocyte mediated immunity#GO:0002703;innate immune response-activating signaling pathway#GO:0002758;immune response-activating cell surface receptor signaling pathway#GO:0002429;positive regulation of natural killer cell mediated immunity#GO:0002717;regulation of response to biotic stimulus#GO:0002831;response to external biotic stimulus#GO:0043207;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of response to stimulus#GO:0048583;positive regulation of defense response#GO:0031349;positive regulation of immune response#GO:0050778;regulation of response to stress#GO:0080134;positive regulation of leukocyte mediated immunity#GO:0002705;defense response#GO:0006952;response to external stimulus#GO:0009605;positive regulation of response to biotic stimulus#GO:0002833;innate immune response#GO:0045087;regulation of innate immune response#GO:0045088;positive regulation of innate immune response#GO:0045089;positive regulation of cellular process#GO:0048522;immune response#GO:0006955;positive regulation of natural killer cell mediated cytotoxicity#GO:0045954;activation of innate immune response#GO:0002218;positive regulation of immune effector process#GO:0002699;response to other organism#GO:0051707;immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007;regulation of natural killer cell mediated cytotoxicity#GO:0042269;positive regulation of response to stimulus#GO:0048584;regulation of cell killing#GO:0031341;regulation of lymphocyte mediated immunity#GO:0002706;immune system process#GO:0002376;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;immune response-regulating signaling pathway#GO:0002764;natural killer cell mediated immunity#GO:0002228;regulation of biological process#GO:0050789;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;cell surface receptor signaling pathway#GO:0007166;immune effector process#GO:0002252;positive regulation of response to external stimulus#GO:0032103;immune response-activating signaling pathway#GO:0002757;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;defense response to symbiont#GO:0140546;signal transduction#GO:0007165;activation of immune response#GO:0002253;positive regulation of immune system process#GO:0002684;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;defense response to other organism#GO:0098542;regulation of response to external stimulus#GO:0032101 membrane#GO:0016020;cell periphery#GO:0071944;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 defense/immunity protein#PC00090 HUMAN|HGNC=30438|UniProtKB=Q8IYB1 Q8IYB1 MB21D2 PTHR10656:SF47 CELL FATE DETERMINING PROTEIN MAB21-RELATED NUCLEOTIDYLTRANSFERASE MB21D2 nucleotidyltransferase#PC00174;transferase#PC00220 HUMAN|HGNC=4080|UniProtKB=Q16445 Q16445 GABRA6 PTHR18945:SF335 NEUROTRANSMITTER GATED ION CHANNEL GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-6 gated channel activity#GO:0022836;transmembrane signaling receptor activity#GO:0004888;ligand-gated monoatomic ion channel activity#GO:0015276;molecular transducer activity#GO:0060089;channel activity#GO:0015267;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;neurotransmitter receptor activity#GO:0030594;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;signaling receptor activity#GO:0038023 cellular component assembly#GO:0022607;monoatomic anion transmembrane transport#GO:0098656;nervous system development#GO:0007399;cellular component biogenesis#GO:0044085;synaptic signaling#GO:0099536;cellular process#GO:0009987;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;chloride transport#GO:0006821;synapse assembly#GO:0007416;signaling#GO:0023052;cell junction assembly#GO:0034329;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;transmembrane transport#GO:0055085;inorganic anion transport#GO:0015698;monoatomic ion transport#GO:0006811;animal gross anatomical part developmental process#GO:0160108;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;monoatomic ion transmembrane transport#GO:0034220;establishment of localization#GO:0051234;developmental process#GO:0032502;transport#GO:0006810;anterograde trans-synaptic signaling#GO:0098916;cell junction organization#GO:0034330;monoatomic anion transport#GO:0006820;chemical synaptic transmission#GO:0007268;chloride transmembrane transport#GO:1902476;localization#GO:0051179;cell communication#GO:0007154;anatomical structure development#GO:0048856;system development#GO:0048731;trans-synaptic signaling#GO:0099537;synapse organization#GO:0050808 cellular anatomical structure#GO:0110165;synapse#GO:0045202;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;postsynapse#GO:0098794;cell projection membrane#GO:0031253;dendrite#GO:0030425;dendritic tree#GO:0097447;leading edge membrane#GO:0031256;protein-containing complex#GO:0032991;plasma membrane region#GO:0098590;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;membrane#GO:0016020;cell leading edge#GO:0031252;cell periphery#GO:0071944;neuron projection#GO:0043005;cell junction#GO:0030054;neuron projection membrane#GO:0032589;signaling receptor complex#GO:0043235 ligand-gated ion channel#PC00141 HUMAN|HGNC=2701|UniProtKB=P43146 P43146 DCC PTHR10075:SF115 BASIGIN RELATED NETRIN RECEPTOR DCC cell adhesion molecule#PC00069 Axon guidance mediated by Slit/Robo#P00008>DCC#P00352;Axon guidance mediated by netrin#P00009>DCC/UNC-40#P00360 HUMAN|HGNC=14993|UniProtKB=Q8NHC4 Q8NHC4 OR10J5 PTHR26453:SF700 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 10J5 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;nervous system process#GO:0050877;sensory perception#GO:0007600;system process#GO:0003008;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;detection of chemical stimulus#GO:0009593;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;response to chemical#GO:0042221;response to stimulus#GO:0050896 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=17346|UniProtKB=Q13523 Q13523 PRP4K PTHR24056:SF538 CELL DIVISION PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE PRP4 HOMOLOG protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=28199|UniProtKB=Q9BRD0 Q9BRD0 BUD13 PTHR31809:SF0 BUD13 HOMOLOG BUD13 HOMOLOG mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 spliceosomal complex#GO:0005681;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;U2-type spliceosomal complex#GO:0005684;intracellular membrane-bounded organelle#GO:0043231;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=7693|UniProtKB=Q16795 Q16795 NDUFA9 PTHR12126:SF10 NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 9, MITOCHONDRIAL binding#GO:0005488;protein-containing complex binding#GO:0044877 small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152;ubiquinone biosynthetic process#GO:0006744;ketone biosynthetic process#GO:0042181;cellular process#GO:0009987;ketone metabolic process#GO:0042180;biosynthetic process#GO:0009058;small molecule metabolic process#GO:0044281 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 oxidoreductase#PC00176 HUMAN|HGNC=11134|UniProtKB=Q16533 Q16533 SNAPC1 PTHR15131:SF3 SMALL NUCLEAR RNA ACTIVATING COMPLEX, POLYPEPTIDE 1 SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 1 binding#GO:0005488;nucleic acid binding#GO:0003676;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565 nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;snRNA transcription#GO:0009301;transcription by RNA polymerase III#GO:0006383;primary metabolic process#GO:0044238;snRNA transcription by RNA polymerase II#GO:0042795;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;snRNA transcription by RNA polymerase III#GO:0042796;snRNA metabolic process#GO:0016073;nucleic acid biosynthetic process#GO:0141187 transcription regulator complex#GO:0005667;protein-containing complex#GO:0032991 HUMAN|HGNC=16219|UniProtKB=Q8TEA8 Q8TEA8 DTD1 PTHR10472:SF5 D-TYROSYL-TRNA TYR DEACYLASE D-AMINOACYL-TRNA DEACYLASE 1 catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;deacylase activity#GO:0160215;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;catalytic activity, acting on a tRNA#GO:0140101;carboxylic ester hydrolase activity#GO:0052689 cellular process#GO:0009987;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;nucleobase-containing compound metabolic process#GO:0006139;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;esterase#PC00097;hydrolase#PC00121 HUMAN|HGNC=17438|UniProtKB=Q7Z7G1 Q7Z7G1 CLNK PTHR14098:SF2 SH2 DOMAIN CONTAINING PROTEIN CYTOKINE-DEPENDENT HEMATOPOIETIC CELL LINKER molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 cell activation#GO:0001775;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;immune system process#GO:0002376;intracellular signal transduction#GO:0035556;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;leukocyte activation#GO:0045321;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cell surface receptor signaling pathway#GO:0007166;cellular process#GO:0009987;signal transduction#GO:0007165;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;myeloid leukocyte activation#GO:0002274 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 scaffold/adaptor protein#PC00226 HUMAN|HGNC=8979|UniProtKB=P27986 P27986 PIK3R1 PTHR10155:SF3 PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234 cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;cellular response to hormone stimulus#GO:0032870;regulation of cellular process#GO:0050794;signaling#GO:0023052;cellular response to peptide hormone stimulus#GO:0071375;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;response to insulin#GO:0032868;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;response to nitrogen compound#GO:1901698;cellular response to chemical stimulus#GO:0070887;response to oxygen-containing compound#GO:1901700;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;insulin receptor signaling pathway#GO:0008286;response to chemical#GO:0042221;cellular response to nitrogen compound#GO:1901699;biological regulation#GO:0065007;response to peptide hormone#GO:0043434;response to hormone#GO:0009725;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;cellular process#GO:0009987;cell surface receptor signaling pathway#GO:0007166;cellular response to insulin stimulus#GO:0032869 extrinsic component of membrane#GO:0019898;transferase complex#GO:1990234;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;membrane#GO:0016020;membrane protein complex#GO:0098796 kinase modulator#PC00140 CCKR signaling map#P06959>p85#P07212;T cell activation#P00053>PI3K#P01322;p53 pathway feedback loops 2#P04398>PI3K#P04661;Integrin signalling pathway#P00034>PI3K#P00936;VEGF signaling pathway#P00056>PI3K#P01413;Gonadotropin-releasing hormone receptor pathway#P06664>PI3K#P06766;Axon guidance mediated by netrin#P00009>PI3K#P00363;Angiogenesis#P00005>PI3K#P00236;Endothelin signaling pathway#P00019>PI3K#P00577;p53 pathway#P00059>PI3K#P04609;PI3 kinase pathway#P00048>p85#P01202;Hypoxia response via HIF activation#P00030>PI3K#P00823;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>PI3K#P00900;PDGF signaling pathway#P00047>PI3K#P01168 HUMAN|HGNC=24141|UniProtKB=Q6ZMB0 Q6ZMB0 B3GNT6 PTHR11214:SF382 BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE ACETYLGALACTOSAMINYL-O-GLYCOSYL-GLYCOPROTEIN BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740;galactosyltransferase activity#GO:0008378;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757 aminoglycan metabolic process#GO:0006022;metabolic process#GO:0008152;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;aminoglycan biosynthetic process#GO:0006023;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;biosynthetic process#GO:0009058 Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane#GO:0016020;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 transferase#PC00220;glycosyltransferase#PC00111 HUMAN|HGNC=20756|UniProtKB=Q7Z3T8 Q7Z3T8 ZFYVE16 PTHR46319:SF1 ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 16 protein transport#GO:0015031;localization#GO:0051179;cellular localization#GO:0051641;lysosomal transport#GO:0007041;protein localization to vacuole#GO:0072665;establishment of protein localization to vacuole#GO:0072666;protein localization to organelle#GO:0033365;protein targeting#GO:0006605;protein localization to lysosome#GO:0061462;endosomal transport#GO:0016197;intracellular protein localization#GO:0008104;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;vacuolar transport#GO:0007034;transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;macromolecule localization#GO:0033036;protein targeting to vacuole#GO:0006623 intracellular organelle#GO:0043229;endosome#GO:0005768;endosome membrane#GO:0010008;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;early endosome membrane#GO:0031901;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;membrane#GO:0016020;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659 TGF-beta signaling pathway#P00052>SARA#P01281 HUMAN|HGNC=5138|UniProtKB=P09016 P09016 HOXD4 PTHR45771:SF5 HOMEOTIC PROTEIN DEFORMED HOMEOBOX PROTEIN HOX-D4 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676 multicellular organismal process#GO:0032501;positive regulation of DNA-templated transcription#GO:0045893;regionalization#GO:0003002;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;skeletal system morphogenesis#GO:0048705;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;developmental process#GO:0032502;regulation of cellular process#GO:0050794;animal organ morphogenesis#GO:0009887;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;embryo development ending in birth or egg hatching#GO:0009792;embryonic organ development#GO:0048568;pattern specification process#GO:0007389;positive regulation of macromolecule metabolic process#GO:0010604;embryo development#GO:0009790;positive regulation of biological process#GO:0048518;animal organ development#GO:0048513;multicellular organism development#GO:0007275;embryonic morphogenesis#GO:0048598;anterior/posterior pattern specification#GO:0009952;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of transcription by RNA polymerase II#GO:0006357;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;skeletal system development#GO:0001501;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;chordate embryonic development#GO:0043009;animal gross anatomical part developmental process#GO:0160108 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=5194|UniProtKB=O14792 O14792 HS3ST1 PTHR10605:SF16 HEPARAN SULFATE SULFOTRANSFERASE HEPARAN SULFATE GLUCOSAMINE 3-O-SULFOTRANSFERASE 1 transferase activity, transferring sulphur-containing groups#GO:0016782;sulfotransferase activity#GO:0008146;catalytic activity#GO:0003824;transferase activity#GO:0016740 metabolite interconversion enzyme#PC00262;transferase#PC00220 HUMAN|HGNC=12782|UniProtKB=P56703 P56703 WNT3 PTHR12027:SF82 WNT RELATED PROTO-ONCOGENE WNT-3 cytokine activity#GO:0005125;binding#GO:0005488;signaling receptor binding#GO:0005102;molecular function activator activity#GO:0140677;protein binding#GO:0005515;G protein-coupled receptor binding#GO:0001664;frizzled binding#GO:0005109;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772 anatomical structure development#GO:0048856;cell communication#GO:0007154;canonical Wnt signaling pathway#GO:0060070;system development#GO:0048731;cell fate commitment#GO:0045165;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;response to stimulus#GO:0050896;Wnt signaling pathway#GO:0016055;signaling#GO:0023052;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;neurogenesis#GO:0022008;cell surface receptor signaling pathway#GO:0007166;neuron differentiation#GO:0030182;developmental process#GO:0032502;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 Cadherin signaling pathway#P00012>Wnt#P00474;Wnt signaling pathway#P00057>Wnt#P01444;Alzheimer disease-presenilin pathway#P00004>Wnt#P00142 HUMAN|HGNC=23999|UniProtKB=Q9P0I2 Q9P0I2 EMC3 PTHR13116:SF10 ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3 ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3 molecular carrier activity#GO:0140104;protein carrier activity#GO:0140597;membrane insertase activity#GO:0032977 protein localization to organelle#GO:0033365;endoplasmic reticulum organization#GO:0007029;protein insertion into ER membrane#GO:0045048;cellular component organization#GO:0016043;localization#GO:0051179;cellular localization#GO:0051641;localization within membrane#GO:0051668;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;protein insertion into membrane#GO:0051205;tail-anchored membrane protein insertion into ER membrane#GO:0071816;establishment of protein localization#GO:0045184;cellular process#GO:0009987;macromolecule localization#GO:0033036;organelle organization#GO:0006996;establishment of protein localization to membrane#GO:0090150;intracellular protein localization#GO:0008104;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234 endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;endoplasmic reticulum protein-containing complex#GO:0140534;membrane#GO:0016020;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;EMC complex#GO:0072546;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175 HUMAN|HGNC=16062|UniProtKB=Q6UUV9 Q6UUV9 CRTC1 PTHR13589:SF14 CREB-REGULATED TRANSCRIPTION COACTIVATOR CREB-REGULATED TRANSCRIPTION COACTIVATOR 1 transcription coregulator activity#GO:0003712;binding#GO:0005488;transcription factor binding#GO:0008134;transcription regulator activity#GO:0140110;transcription coactivator activity#GO:0003713;protein binding#GO:0005515;DNA-binding transcription factor binding#GO:0140297 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of DNA-templated transcription#GO:0045893;cellular response to nitrogen compound#GO:1901699;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;response to nitrogen compound#GO:1901698;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;cellular response to stimulus#GO:0051716;positive regulation of transcription by RNA polymerase II#GO:0045944;response to chemical#GO:0042221;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;positive regulation of biological process#GO:0048518;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;response to oxygen-containing compound#GO:1901700;cellular response to chemical stimulus#GO:0070887;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 transcription cofactor#PC00217;gene-specific transcriptional regulator#PC00264 Gonadotropin-releasing hormone receptor pathway#P06664>TORC1#P06788 HUMAN|HGNC=4127|UniProtKB=Q7Z7M9 Q7Z7M9 GALNT5 PTHR11675:SF130 N-ACETYLGALACTOSAMINYLTRANSFERASE POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 5 polypeptide N-acetylgalactosaminyltransferase activity#GO:0004653;hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;acetylgalactosaminyltransferase activity#GO:0008376;UDP-glycosyltransferase activity#GO:0008194;catalytic activity, acting on a protein#GO:0140096 biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;protein O-linked glycosylation#GO:0006493;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 transferase#PC00220;glycosyltransferase#PC00111 HUMAN|HGNC=14943|UniProtKB=Q9H7J1 Q9H7J1 PPP1R3E PTHR12307:SF20 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 3E enzyme binding#GO:0019899;phosphatase binding#GO:0019902;polysaccharide binding#GO:0030247;binding#GO:0005488;protein phosphatase binding#GO:0019903;carbohydrate binding#GO:0030246;protein binding#GO:0005515 regulation of glycogen biosynthetic process#GO:0005979;regulation of carbohydrate metabolic process#GO:0006109;regulation of biosynthetic process#GO:0009889;regulation of polysaccharide biosynthetic process#GO:0032885;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of carbohydrate biosynthetic process#GO:0043255;regulation of polysaccharide metabolic process#GO:0032881;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255 catalytic complex#GO:1902494;protein serine/threonine phosphatase complex#GO:0008287;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 phosphatase modulator#PC00184;protein-binding activity modulator#PC00095 HUMAN|HGNC=31746|UniProtKB=A1L4L8 A1L4L8 PLAC8L1 PTHR15907:SF122 DUF614 FAMILY PROTEIN-RELATED PLAC8-LIKE PROTEIN 1 HUMAN|HGNC=13528|UniProtKB=Q9Y2A9 Q9Y2A9 B3GNT3 PTHR11214:SF405 BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE N-ACETYLLACTOSAMINIDE BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE 3 acetylglucosaminyltransferase activity#GO:0008375;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740 metabolic process#GO:0008152;aminoglycan metabolic process#GO:0006022;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;aminoglycan biosynthetic process#GO:0006023;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;biosynthetic process#GO:0009058 membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020 transferase#PC00220;glycosyltransferase#PC00111 HUMAN|HGNC=2625|UniProtKB=P10635 P10635 CYP2D6 PTHR24300:SF1 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 2D6-RELATED tetrapyrrole binding#GO:0046906;binding#GO:0005488;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen#GO:0016712;oxidoreductase activity#GO:0016491;heme binding#GO:0020037;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;monooxygenase activity#GO:0004497;catalytic activity#GO:0003824 unsaturated fatty acid metabolic process#GO:0033559;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;cellular process#GO:0009987;long-chain fatty acid metabolic process#GO:0001676;cellular response to xenobiotic stimulus#GO:0071466;response to chemical#GO:0042221;icosanoid metabolic process#GO:0006690;response to xenobiotic stimulus#GO:0009410;oxoacid metabolic process#GO:0043436;cellular response to chemical stimulus#GO:0070887;olefinic compound metabolic process#GO:0120254;arachidonate metabolic process#GO:0019369;cellular response to stimulus#GO:0051716;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;xenobiotic metabolic process#GO:0006805;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896 intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 oxidoreductase#PC00176;oxygenase#PC00177 HUMAN|HGNC=2904|UniProtKB=Q8TDM6 Q8TDM6 DLG5 PTHR46360:SF1 DISKS LARGE HOMOLOG 5 DISKS LARGE HOMOLOG 5 regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of hippo signaling#GO:0035330;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of hippo signaling#GO:0035331;negative regulation of cell communication#GO:0010648;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;negative regulation of response to stimulus#GO:0048585;negative regulation of signal transduction#GO:0009968;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583 scaffold/adaptor protein#PC00226 HUMAN|HGNC=8569|UniProtKB=P29122 P29122 PCSK6 PTHR42884:SF8 PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED PROPROTEIN CONVERTASE SUBTILISIN_KEXIN TYPE 6 serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233 primary metabolic process#GO:0044238;regulation of hormone levels#GO:0010817;protein metabolic process#GO:0019538;signaling receptor ligand precursor processing#GO:0140448;regulation of biological quality#GO:0065008;proteolysis#GO:0006508;gene expression#GO:0010467;protein maturation#GO:0051604;hormone metabolic process#GO:0042445;biological regulation#GO:0065007;biosynthetic process#GO:0009058;cellular process#GO:0009987;protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059;peptide hormone processing#GO:0016486;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152 Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;external encapsulating structure#GO:0030312;membrane#GO:0016020;extracellular matrix#GO:0031012;Golgi apparatus subcompartment#GO:0098791;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;cell surface#GO:0009986;endomembrane system#GO:0012505;intracellular organelle#GO:0043229;extracellular region#GO:0005576;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 serine protease#PC00203 Alzheimer disease-amyloid secretase pathway#P00003>Furin#P00105;Alzheimer disease-presenilin pathway#P00004>Furin#P00157 HUMAN|HGNC=13375|UniProtKB=Q9H2W1 Q9H2W1 MS4A6A PTHR23320:SF135 MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 6A cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;plasma membrane#GO:0005886;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;cell periphery#GO:0071944;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 transporter#PC00227 HUMAN|HGNC=17313|UniProtKB=Q9UHH9 Q9UHH9 IP6K2 PTHR12400:SF47 INOSITOL POLYPHOSPHATE KINASE INOSITOL HEXAKISPHOSPHATE KINASE 2 phosphotransferase activity, phosphate group as acceptor#GO:0016776;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987;alcohol biosynthetic process#GO:0046165;organophosphate metabolic process#GO:0019637;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;glycerophospholipid metabolic process#GO:0006650;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474;alcohol metabolic process#GO:0006066;metabolic process#GO:0008152;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;phospholipid metabolic process#GO:0006644;phospholipid biosynthetic process#GO:0008654;small molecule metabolic process#GO:0044281;glycerolipid metabolic process#GO:0046486;phosphatidylinositol phosphate biosynthetic process#GO:0046854;organophosphate biosynthetic process#GO:0090407 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 kinase#PC00137 HUMAN|HGNC=17217|UniProtKB=Q14689 Q14689 DIP2A PTHR22754:SF34 DISCO-INTERACTING PROTEIN 2 DIP2 -RELATED DISCO-INTERACTING PROTEIN 2 HOMOLOG A ligase activity#GO:0016874;catalytic activity#GO:0003824;ligase activity, forming carbon-sulfur bonds#GO:0016877 purine-containing compound biosynthetic process#GO:0072522;acetyl-CoA metabolic process#GO:0006084;positive regulation of protein metabolic process#GO:0051247;organophosphate biosynthetic process#GO:0090407;positive regulation of metabolic process#GO:0009893;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;small molecule metabolic process#GO:0044281;regulation of macromolecule metabolic process#GO:0060255;nucleoside phosphate metabolic process#GO:0006753;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing small molecule metabolic process#GO:0055086;acyl-CoA metabolic process#GO:0006637;regulation of protein modification process#GO:0031399;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;sulfur compound metabolic process#GO:0006790;organophosphate metabolic process#GO:0019637;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of macromolecule metabolic process#GO:0010604;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 HUMAN|HGNC=10481|UniProtKB=P34925 P34925 RYK PTHR24416:SF349 TYROSINE-PROTEIN KINASE RECEPTOR INACTIVE TYROSINE-PROTEIN KINASE RYK transmembrane signaling receptor activity#GO:0004888;phosphotransferase activity, alcohol group as acceptor#GO:0016773;molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714;protein kinase activity#GO:0004672;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;signaling receptor activity#GO:0038023;transmembrane receptor protein kinase activity#GO:0019199 cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;signaling#GO:0023052;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051897;regulation of signaling#GO:0023051;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of intracellular signal transduction#GO:1902531;regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051896;positive regulation of signaling#GO:0023056;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of response to stimulus#GO:0048584;regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166;positive regulation of intracellular signal transduction#GO:1902533 membrane#GO:0016020;signaling receptor complex#GO:0043235;cell periphery#GO:0071944;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=12124|UniProtKB=A0A0B4J265 A0A0B4J265 TRAV26-2 PTHR19433:SF86 T-CELL RECEPTOR ALPHA CHAIN V REGION-RELATED T CELL RECEPTOR ALPHA VARIABLE 26-2 response to biotic stimulus#GO:0009607;response to bacterium#GO:0009617;response to external biotic stimulus#GO:0043207;response to external stimulus#GO:0009605;biological process involved in interspecies interaction between organisms#GO:0044419;response to other organism#GO:0051707;response to stimulus#GO:0050896 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=17024|UniProtKB=Q9UIL8 Q9UIL8 PHF11 PTHR12420:SF4 PHD FINGER PROTEIN PHD FINGER PROTEIN 11 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA metabolism protein#PC00009 HUMAN|HGNC=9441|UniProtKB=P51817 P51817 PRKX PTHR24353:SF133 CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674 biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cell adhesion#GO:0007155;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189 intracellular anatomical structure#GO:0005622;protein kinase complex#GO:1902911;intracellular protein-containing complex#GO:0140535;serine/threonine protein kinase complex#GO:1902554;transferase complex, transferring phosphorus-containing groups#GO:0061695;transferase complex#GO:1990234;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;cytosol#GO:0005829 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 Metabotropic glutamate receptor group I pathway#P00041>PKA#P01059;Histamine H2 receptor mediated signaling pathway#P04386>PKA#P04491;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PKA#P00862;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>PKA#P01075;Enkephalin release#P05913>PKA#P05972;Beta1 adrenergic receptor signaling pathway#P04377>PKA#P04437;Metabotropic glutamate receptor group III pathway#P00039>PKA#P01035;5HT1 type receptor mediated signaling pathway#P04373>PKA#P04403;Metabotropic glutamate receptor group II pathway#P00040>PKA#P01050;Beta2 adrenergic receptor signaling pathway#P04378>PKA#P04444;Dopamine receptor mediated signaling pathway#P05912>PKA#P05946 HUMAN|HGNC=18312|UniProtKB=Q8NFP0 Q8NFP0 PXT1 PTHR40381:SF1 PEROXISOMAL TESTIS-SPECIFIC PROTEIN 1 PEROXISOMAL TESTIS-SPECIFIC PROTEIN 1 HUMAN|HGNC=11455|UniProtKB=P0DMM9 P0DMM9 SULT1A3 PTHR11783:SF308 SULFOTRANSFERASE SULT SULFOTRANSFERASE 1A3-RELATED catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring sulphur-containing groups#GO:0016782;sulfotransferase activity#GO:0008146 cellular process#GO:0009987;metabolic process#GO:0008152;sulfur compound metabolic process#GO:0006790 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 metabolite interconversion enzyme#PC00262;transferase#PC00220 HUMAN|HGNC=2622|UniProtKB=P10632 P10632 CYP2C8 PTHR24300:SF438 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 2C8 monooxygenase activity#GO:0004497;catalytic activity#GO:0003824;heme binding#GO:0020037;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen#GO:0016712;oxidoreductase activity#GO:0016491;binding#GO:0005488;tetrapyrrole binding#GO:0046906 olefinic compound metabolic process#GO:0120254;oxoacid metabolic process#GO:0043436;cellular response to chemical stimulus#GO:0070887;response to xenobiotic stimulus#GO:0009410;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;xenobiotic metabolic process#GO:0006805;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;monocarboxylic acid metabolic process#GO:0032787;arachidonate metabolic process#GO:0019369;cellular response to stimulus#GO:0051716;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;unsaturated fatty acid metabolic process#GO:0033559;icosanoid metabolic process#GO:0006690;response to chemical#GO:0042221;cellular response to xenobiotic stimulus#GO:0071466;long-chain fatty acid metabolic process#GO:0001676;cellular process#GO:0009987 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 oxidoreductase#PC00176;oxygenase#PC00177 HUMAN|HGNC=12726|UniProtKB=P04275 P04275 VWF PTHR11339:SF361 EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED VON WILLEBRAND FACTOR extracellular matrix structural constituent#GO:0005201;structural molecule activity#GO:0005198 response to stimulus#GO:0050896;regulation of body fluid levels#GO:0050878;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;hemostasis#GO:0007599;response to wounding#GO:0009611;response to stress#GO:0006950;coagulation#GO:0050817;cellular process#GO:0009987;cell-substrate adhesion#GO:0031589;blood coagulation#GO:0007596;regulation of biological quality#GO:0065008;wound healing#GO:0042060;cell adhesion#GO:0007155 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012 extracellular matrix protein#PC00102 Blood coagulation#P00011>vWF#P00448;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>EMC#P00863 HUMAN|HGNC=18665|UniProtKB=Q96BQ1 Q96BQ1 FAM3D PTHR14592:SF9 UNCHARACTERIZED FAM3 PROTEIN FAM3D signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;cytokine activity#GO:0005125;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell communication#GO:0007154 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090;antimicrobial response protein#PC00051 HUMAN|HGNC=29955|UniProtKB=Q86UW1 Q86UW1 SLC51A PTHR23423:SF11 ORGANIC SOLUTE TRANSPORTER-RELATED ORGANIC SOLUTE TRANSPORTER SUBUNIT ALPHA transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 macromolecule localization#GO:0033036;lipid transport#GO:0006869;bile acid and bile salt transport#GO:0015721;organic acid transport#GO:0015849;carboxylic acid transport#GO:0046942;transport#GO:0006810;lipid localization#GO:0010876;organic hydroxy compound transport#GO:0015850;monocarboxylic acid transport#GO:0015718;localization#GO:0051179;establishment of localization#GO:0051234 intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;endomembrane system#GO:0012505 transporter#PC00227 HUMAN|HGNC=29203|UniProtKB=Q9ULP9 Q9ULP9 TBC1D24 PTHR23353:SF34 RAB-GAP/TBC-RELATED TBC1 DOMAIN FAMILY MEMBER 24 GTPase-activating protein#PC00257 N-acetylglucosamine metabolism#P02756>N-acetylglucosamine-6-phosphate deacetylase#P03036 HUMAN|HGNC=23692|UniProtKB=P25106 P25106 ACKR3 PTHR10489:SF931 CELL ADHESION MOLECULE ATYPICAL CHEMOKINE RECEPTOR 3 cytokine receptor activity#GO:0004896;cytokine binding#GO:0019955;signaling receptor activity#GO:0038023;immune receptor activity#GO:0140375;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488;molecular transducer activity#GO:0060089;protein binding#GO:0005515 response to external stimulus#GO:0009605;calcium-mediated signaling#GO:0019722;immune response#GO:0006955;signal transduction#GO:0007165;cellular process#GO:0009987;taxis#GO:0042330;response to chemical#GO:0042221;cell migration#GO:0016477;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124;cellular response to chemical stimulus#GO:0070887;immune system process#GO:0002376;positive regulation of cytosolic calcium ion concentration#GO:0007204;chemotaxis#GO:0006935;cell communication#GO:0007154;cell chemotaxis#GO:0060326;intracellular signal transduction#GO:0035556;regulation of biological quality#GO:0065008;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell motility#GO:0048870;signaling#GO:0023052;locomotion#GO:0040011 membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cell adhesion molecule#PC00069 HUMAN|HGNC=18022|UniProtKB=Q96A56 Q96A56 TP53INP1 PTHR31671:SF0 DIABETES AND OBESITY REGULATED, ISOFORM G TUMOR PROTEIN P53-INDUCIBLE NUCLEAR PROTEIN 1 transcription regulator activity#GO:0140110;protein-macromolecule adaptor activity#GO:0030674;transcription coregulator activity#GO:0003712;molecular adaptor activity#GO:0060090;protein-membrane adaptor activity#GO:0043495;transcription coactivator activity#GO:0003713 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;macroautophagy#GO:0016236;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;vacuole organization#GO:0007033;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;organelle assembly#GO:0070925;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;autophagosome assembly#GO:0000045;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;positive regulation of macromolecule metabolic process#GO:0010604;cellular component assembly#GO:0022607;cellular process#GO:0009987;autophagosome organization#GO:1905037;positive regulation of biological process#GO:0048518;autophagy#GO:0006914;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;process utilizing autophagic mechanism#GO:0061919;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of biological process#GO:0050789;cellular component organization#GO:0016043 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;autophagosome#GO:0005776;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;vacuole#GO:0005773;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634 HUMAN|HGNC=25436|UniProtKB=Q8N3T6 Q8N3T6 TMEM132C PTHR13388:SF4 DETONATOR, ISOFORM E TRANSMEMBRANE PROTEIN 132C membrane#GO:0016020;cellular anatomical structure#GO:0110165 HUMAN|HGNC=13251|UniProtKB=Q9UJ99 Q9UJ99 CDH22 PTHR24027:SF311 CADHERIN-23 CADHERIN-22 cell adhesion molecule binding#GO:0050839;binding#GO:0005488;beta-catenin binding#GO:0008013;protein binding#GO:0005515 cell adhesion#GO:0007155;anatomical structure development#GO:0048856;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;cell junction assembly#GO:0034329;adherens junction organization#GO:0034332;cell motility#GO:0048870;cell junction organization#GO:0034330;cell morphogenesis#GO:0000902;cell-cell junction assembly#GO:0007043;cell-cell junction organization#GO:0045216;developmental process#GO:0032502;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cell-cell adhesion#GO:0098609;cellular component biogenesis#GO:0044085;cell migration#GO:0016477;cellular component assembly#GO:0022607 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane#GO:0016020;cell-cell junction#GO:0005911;membrane protein complex#GO:0098796;anchoring junction#GO:0070161;adherens junction#GO:0005912;extrinsic component of plasma membrane#GO:0019897;extrinsic component of membrane#GO:0019898;cell junction#GO:0030054 cell adhesion molecule#PC00069;cadherin#PC00057 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HUMAN|HGNC=11289|UniProtKB=P36956 P36956 SREBF1 PTHR46062:SF2 STEROL REGULATORY ELEMENT-BINDING PROTEIN STEROL REGULATORY ELEMENT-BINDING PROTEIN 1 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=21108|UniProtKB=Q5JS54 Q5JS54 PSMG4 PTHR33559:SF1 PROTEASOME ASSEMBLY CHAPERONE 4 PROTEASOME ASSEMBLY CHAPERONE 4 chaperone#PC00072 HUMAN|HGNC=10787|UniProtKB=Q13243 Q13243 SRSF5 PTHR23147:SF237 SERINE/ARGININE RICH SPLICING FACTOR SERINE_ARGININE-RICH SPLICING FACTOR 5 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;nuclear speck#GO:0016607;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;membraneless organelle#GO:0043228;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;nuclear body#GO:0016604;intracellular membraneless organelle#GO:0043232 RNA splicing factor#PC00148;RNA metabolism protein#PC00031;RNA processing factor#PC00147 HUMAN|HGNC=3015|UniProtKB=Q14195 Q14195 DPYSL3 PTHR11647:SF57 HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER DIHYDROPYRIMIDINASE-RELATED PROTEIN 3 dihydropyrimidinase activity#GO:0004157;catalytic activity#GO:0003824;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides#GO:0016812;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity#GO:0016787 metabolic process#GO:0008152;nucleobase metabolic process#GO:0009112;nucleobase-containing small molecule metabolic process#GO:0055086;actin filament organization#GO:0007015;pyrimidine nucleobase metabolic process#GO:0006206;cellular component organization or biogenesis#GO:0071840;pyrimidine-containing compound metabolic process#GO:0072527;cellular process#GO:0009987;organelle organization#GO:0006996;nucleobase-containing compound metabolic process#GO:0006139;cytoskeleton organization#GO:0007010;actin filament-based process#GO:0030029;supramolecular fiber organization#GO:0097435;pyrimidine nucleobase catabolic process#GO:0006208;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;nucleobase catabolic process#GO:0046113;actin cytoskeleton organization#GO:0030036;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 hydrolase#PC00121 Axon guidance mediated by semaphorins#P00007>CRMP#P00339;Pyrimidine Metabolism#P02771>Dihydropyrimidinase#P03125 HUMAN|HGNC=29264|UniProtKB=Q9P2H0 Q9P2H0 CEP126 PTHR31191:SF4 CENTROSOMAL PROTEIN CEP126 CENTROSOMAL PROTEIN OF 126 KDA organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection organization#GO:0120036;plasma membrane bounded cell projection assembly#GO:0120031;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cell projection organization#GO:0030030;cytoplasmic microtubule organization#GO:0031122;organelle assembly#GO:0070925;microtubule cytoskeleton organization#GO:0000226;supramolecular fiber organization#GO:0097435;cilium organization#GO:0044782 microtubule cytoskeleton#GO:0015630;ciliary base#GO:0097546;intracellular membraneless organelle#GO:0043232;centrosome#GO:0005813;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;midbody#GO:0030496;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;cilium#GO:0005929;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 DNA metabolism protein#PC00009 HUMAN|HGNC=28845|UniProtKB=Q71SY5 Q71SY5 MED25 PTHR12433:SF10 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 25 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 25 regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of biological process#GO:0050789;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604 nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular anatomical structure#GO:0005622;mediator complex#GO:0016592 general transcription factor#PC00259;RNA metabolism protein#PC00031 HUMAN|HGNC=53075|UniProtKB=P0DP42 P0DP42 TMEM225B PTHR36477:SF2 TRANSMEMBRANE PROTEIN 225 TRANSMEMBRANE PROTEIN 225B HUMAN|HGNC=20857|UniProtKB=Q9H9S0 Q9H9S0 NANOG PTHR24327:SF79 HOMEOBOX PROTEIN HOMEOBOX PROTEIN NANOG-RELATED sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676 developmental process#GO:0032502;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;stem cell population maintenance#GO:0019827;cellular process#GO:0009987;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;maintenance of cell number#GO:0098727;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255 gene-specific transcriptional regulator#PC00264;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=24845|UniProtKB=Q9BXF6 Q9BXF6 RAB11FIP5 PTHR15746:SF14 RAB11-RELATED RAB11 FAMILY-INTERACTING PROTEIN 5 localization#GO:0051179;establishment of localization#GO:0051234;secretion#GO:0046903;secretion by cell#GO:0032940;exocytosis#GO:0006887;regulated exocytosis#GO:0045055;transport#GO:0006810;vesicle-mediated transport#GO:0016192;export from cell#GO:0140352;cellular process#GO:0009987 intracellular organelle#GO:0043229;endosome#GO:0005768;endocytic vesicle#GO:0030139;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;vesicle#GO:0031982;mitochondrion#GO:0005739;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;recycling endosome#GO:0055037;secretory vesicle#GO:0099503;cytoplasm#GO:0005737;endomembrane system#GO:0012505;phagocytic vesicle#GO:0045335 small GTPase#PC00208 HUMAN|HGNC=7637|UniProtKB=P55209 P55209 NAP1L1 PTHR11875:SF145 TESTIS-SPECIFIC Y-ENCODED PROTEIN NUCLEOSOME ASSEMBLY PROTEIN 1-LIKE 1 binding#GO:0005488;chromatin binding#GO:0003682;histone binding#GO:0042393;protein binding#GO:0005515 protein-containing complex organization#GO:0043933;nucleosome organization#GO:0034728;cellular component organization or biogenesis#GO:0071840;protein-DNA complex organization#GO:0071824;protein-DNA complex assembly#GO:0065004;chromatin organization#GO:0006325;chromatin remodeling#GO:0006338;cellular component assembly#GO:0022607;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=26864|UniProtKB=Q8IY85 Q8IY85 EFCAB13 PTHR22656:SF1 EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 13 EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 13 HUMAN|HGNC=12212|UniProtKB=A0A576 A0A576 TRBV3-1 PTHR23268:SF92 T-CELL RECEPTOR BETA CHAIN T CELL RECEPTOR BETA VARIABLE 3-1 cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=17613|UniProtKB=Q9NZS9 Q9NZS9 BFAR PTHR15898:SF21 BIFUNCTIONAL APOPTOSIS REGULATOR BIFUNCTIONAL APOPTOSIS REGULATOR acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238 HUMAN|HGNC=8622|UniProtKB=Q06710 Q06710 PAX8 PTHR45636:SF6 PAIRED BOX PROTEIN PAX-6-RELATED-RELATED PAIRED BOX PROTEIN PAX-8 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;animal gross anatomical part developmental process#GO:0160108;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;nervous system development#GO:0007399;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;developmental process#GO:0032502;sensory organ development#GO:0007423;regulation of gene expression#GO:0010468;animal organ development#GO:0048513;regulation of biosynthetic process#GO:0009889;multicellular organism development#GO:0007275 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 HUMAN|HGNC=22401|UniProtKB=Q7L273 Q7L273 KCTD9 PTHR14136:SF39 BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD9 BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD9 HUMAN|HGNC=14470|UniProtKB=Q8NG04 Q8NG04 SLC26A10P PTHR11814:SF272 SULFATE TRANSPORTER SOLUTE CARRIER FAMILY 26 MEMBER 10P-RELATED carboxylic acid transmembrane transporter activity#GO:0046943;chloride transmembrane transporter activity#GO:0015108;bicarbonate transmembrane transporter activity#GO:0015106;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic anion transmembrane transporter activity#GO:0008509;monoatomic ion transmembrane transporter activity#GO:0015075;dicarboxylic acid transmembrane transporter activity#GO:0005310 transport#GO:0006810;chloride transport#GO:0006821;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;chloride transmembrane transport#GO:1902476;cellular process#GO:0009987;monoatomic anion transport#GO:0006820;monoatomic ion transmembrane transport#GO:0034220;monoatomic anion transmembrane transport#GO:0098656 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227 HUMAN|HGNC=56772|UniProtKB=Q6B8I1 Q6B8I1 DUSP13A PTHR45682:SF3 AGAP008228-PA DUAL SPECIFICITY PROTEIN PHOSPHATASE 13A phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;protein tyrosine/serine/threonine phosphatase activity#GO:0008138;phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787 regulation of MAPK cascade#GO:0043408;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;negative regulation of response to stimulus#GO:0048585;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;regulation of biological process#GO:0050789;negative regulation of MAPK cascade#GO:0043409;negative regulation of biological process#GO:0048519;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protein phosphatase#PC00195 HUMAN|HGNC=5226|UniProtKB=O75031 O75031 HSF2BP PTHR15434:SF2 HEAT SHOCK FACTOR 2-BINDING PROTEIN HEAT SHOCK FACTOR 2-BINDING PROTEIN HUMAN|HGNC=7879|UniProtKB=O75175 O75175 CNOT3 PTHR23326:SF34 CCR4 NOT-RELATED CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 3 RNA catabolic process#GO:0006401;regulation of biological quality#GO:0065008;RNA metabolic process#GO:0016070;positive regulation of metabolic process#GO:0009893;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;regulation of mRNA stability#GO:0043488;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;macromolecule catabolic process#GO:0009057;positive regulation of mRNA metabolic process#GO:1903313;mRNA destabilization#GO:0061157;metabolic process#GO:0008152;regulation of mRNA metabolic process#GO:1903311;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;RNA destabilization#GO:0050779;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of multicellular organismal process#GO:0051239;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA stability#GO:0043487;regulation of RNA metabolic process#GO:0051252;positive regulation of mRNA catabolic process#GO:0061014;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;positive regulation of RNA metabolic process#GO:0051254;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;nuclear-transcribed mRNA poly(A) tail shortening#GO:0000289;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;positive regulation of catabolic process#GO:0009896;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;macromolecule metabolic process#GO:0043170;nucleic acid catabolic process#GO:0141188;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;nucleobase-containing compound catabolic process#GO:0034655;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219 intracellular organelle#GO:0043229;P-body#GO:0000932;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;CCR4-NOT complex#GO:0030014;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasmic ribonucleoprotein granule#GO:0036464 general transcription factor#PC00259;RNA metabolism protein#PC00031 HUMAN|HGNC=18080|UniProtKB=Q9Y274 Q9Y274 ST3GAL6 PTHR13713:SF8 SIALYLTRANSFERASE TYPE 2 LACTOSAMINE ALPHA-2,3-SIALYLTRANSFERASE sialyltransferase activity#GO:0008373;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;transferase activity#GO:0016740 glycolipid biosynthetic process#GO:0009247;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;liposaccharide metabolic process#GO:1903509;glycolipid metabolic process#GO:0006664;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;lipid metabolic process#GO:0006629;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;glycoprotein biosynthetic process#GO:0009101;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058 metabolite interconversion enzyme#PC00262;transferase#PC00220 HUMAN|HGNC=26103|UniProtKB=Q5VVM6 Q5VVM6 CCDC30 PTHR34479:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 30 COILED-COIL DOMAIN-CONTAINING PROTEIN 30 HUMAN|HGNC=22960|UniProtKB=Q8NBQ5 Q8NBQ5 HSD17B11 PTHR24322:SF489 PKSB ESTRADIOL 17-BETA-DEHYDROGENASE 11 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491 dehydrogenase#PC00092 HUMAN|HGNC=18049|UniProtKB=Q08AH1 Q08AH1 ACSM1 PTHR43605:SF5 ACYL-COENZYME A SYNTHETASE ACYL-COENZYME A SYNTHETASE ACSM1, MITOCHONDRIAL transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746;ligase activity, forming carbon-sulfur bonds#GO:0016877;ATP-dependent activity#GO:0140657;ligase activity#GO:0016874;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 monocarboxylic acid biosynthetic process#GO:0072330;acyl-CoA metabolic process#GO:0006637;nucleobase-containing small molecule metabolic process#GO:0055086;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;lipid biosynthetic process#GO:0008610;fatty acid biosynthetic process#GO:0006633;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;sulfur compound metabolic process#GO:0006790;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;oxoacid metabolic process#GO:0043436;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;phosphorus metabolic process#GO:0006793;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;monocarboxylic acid metabolic process#GO:0032787;purine-containing compound metabolic process#GO:0072521;carboxylic acid biosynthetic process#GO:0046394 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;intracellular organelle lumen#GO:0070013;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233 metabolite interconversion enzyme#PC00262;ligase#PC00142 HUMAN|HGNC=6400|UniProtKB=Q14974 Q14974 KPNB1 PTHR10527:SF1 IMPORTIN BETA IMPORTIN SUBUNIT BETA-1 molecular carrier activity#GO:0140104;nucleocytoplasmic carrier activity#GO:0140142 intracellular protein localization#GO:0008104;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;macromolecule localization#GO:0033036;import into nucleus#GO:0051170;protein localization to nucleus#GO:0034504;nuclear transport#GO:0051169;protein transport#GO:0015031;protein import into nucleus#GO:0006606;localization#GO:0051179;cellular localization#GO:0051641;nucleocytoplasmic transport#GO:0006913;protein localization to organelle#GO:0033365 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 transporter#PC00227 HUMAN|HGNC=12129|UniProtKB=A0A087WSZ9 A0A087WSZ9 TRAV30 PTHR19433:SF120 T-CELL RECEPTOR ALPHA CHAIN V REGION-RELATED T CELL RECEPTOR ALPHA VARIABLE 30 response to stimulus#GO:0050896;response to external stimulus#GO:0009605;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to other organism#GO:0051707;response to bacterium#GO:0009617;response to biotic stimulus#GO:0009607 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=17208|UniProtKB=Q8TD16 Q8TD16 BICD2 PTHR31233:SF7 BICAUDAL D FAMILY MEMBER PROTEIN BICAUDAL D HOMOLOG 2 protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;cytoskeletal protein binding#GO:0008092 regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;protein localization to organelle#GO:0033365;regulation of cellular process#GO:0050794;microtubule-based movement#GO:0007018;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;cellular component organization#GO:0016043;localization#GO:0051179;microtubule cytoskeleton organization#GO:0000226;regulation of microtubule-based process#GO:0032886;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;regulation of microtubule cytoskeleton organization#GO:0070507;vesicle-mediated transport#GO:0016192;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;cellular process#GO:0009987;organelle organization#GO:0006996;macromolecule localization#GO:0033036;intracellular protein localization#GO:0008104;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;microtubule anchoring at microtubule organizing center#GO:0072393;establishment of localization#GO:0051234;microtubule anchoring#GO:0034453;Golgi vesicle transport#GO:0048193;transport#GO:0006810;protein localization to Golgi apparatus#GO:0034067 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=30327|UniProtKB=O95059 O95059 RPP14 PTHR15441:SF1 RIBONUCLEASE P PROTEIN SUBUNIT P14 RIBONUCLEASE P PROTEIN SUBUNIT P14 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058 membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;endonuclease complex#GO:1905348;membraneless organelle#GO:0043228;intracellular protein-containing complex#GO:0140535;organelle lumen#GO:0043233;organelle#GO:0043226;multimeric ribonuclease P complex#GO:0030681;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;endoribonuclease complex#GO:1902555;ribonuclease P complex#GO:0030677;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 endoribonuclease#PC00094 HUMAN|HGNC=32322|UniProtKB=Q7RTU7 Q7RTU7 SCX PTHR23349:SF5 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR SCLERAXIS sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 basic helix-loop-helix transcription factor#PC00055;DNA-binding transcription factor#PC00218 HUMAN|HGNC=3262|UniProtKB=Q9UL18 Q9UL18 AGO1 PTHR22891:SF17 EUKARYOTIC TRANSLATION INITIATION FACTOR 2C PROTEIN ARGONAUTE-1 RNA binding#GO:0003723;nuclease activity#GO:0004518;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA nuclease activity#GO:0004540;endonuclease activity#GO:0004519;single-stranded RNA binding#GO:0003727;catalytic activity, acting on RNA#GO:0140098;RNA endonuclease activity#GO:0004521;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;regulatory ncRNA-mediated gene silencing#GO:0031047;macromolecule metabolic process#GO:0043170;regulatory ncRNA processing#GO:0070918;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;macromolecule biosynthetic process#GO:0009059;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;post-transcriptional gene silencing#GO:0016441;regulatory ncRNA-mediated post-transcriptional gene silencing#GO:0035194;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of macromolecule metabolic process#GO:0060255;pre-miRNA processing#GO:0031054;regulation of cellular process#GO:0050794;RNA biosynthetic process#GO:0032774;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;gene expression#GO:0010467;RNA processing#GO:0006396;miRNA processing#GO:0035196;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;negative regulation of metabolic process#GO:0009892 nucleus#GO:0005634;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasmic ribonucleoprotein granule#GO:0036464;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 HUMAN|HGNC=14271|UniProtKB=Q86WH2 Q86WH2 RASSF3 PTHR22738:SF8 RASSF RAS ASSOCIATION DOMAIN-CONTAINING PROTEIN 3 cell communication#GO:0007154;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=3662|UniProtKB=P02675 P02675 FGB PTHR19143:SF332 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FIBRINOGEN BETA CHAIN cell activation#GO:0001775;blood coagulation, fibrin clot formation#GO:0072378;cell adhesion#GO:0007155;cell-matrix adhesion#GO:0007160;wound healing#GO:0042060;regulation of biological quality#GO:0065008;protein metabolic process#GO:0019538;protein activation cascade#GO:0072376;cell-substrate adhesion#GO:0031589;hemostasis#GO:0007599;primary metabolic process#GO:0044238;regulation of body fluid levels#GO:0050878;response to stimulus#GO:0050896;platelet aggregation#GO:0070527;metabolic process#GO:0008152;blood coagulation#GO:0007596;platelet activation#GO:0030168;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;coagulation#GO:0050817;response to wounding#GO:0009611;cell-cell adhesion#GO:0098609;response to stress#GO:0006950;homotypic cell-cell adhesion#GO:0034109;biosynthetic process#GO:0009058;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;gene expression#GO:0010467;protein maturation#GO:0051604 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 intercellular signal molecule#PC00207 Plasminogen activating cascade#P00050>Fibrin#P01253;Blood coagulation#P00011>Fibrin polymer cross-linked#P00443;Blood coagulation#P00011>Fibrinogen#P00406;Blood coagulation#P00011>Fibrin monomer#P00418 HUMAN|HGNC=9226|UniProtKB=Q15181 Q15181 PPA1 PTHR10286:SF47 INORGANIC PYROPHOSPHATASE INORGANIC PYROPHOSPHATASE hydrolase activity#GO:0016787;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817 cellular process#GO:0009987;phosphate-containing compound metabolic process#GO:0006796;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739 pyrophosphatase#PC00196 HUMAN|HGNC=234|UniProtKB=O60266 O60266 ADCY3 PTHR45627:SF30 ADENYLATE CYCLASE TYPE 1 ADENYLATE CYCLASE TYPE 3 lyase activity#GO:0016829;adenylate cyclase activity#GO:0004016;catalytic activity#GO:0003824;phosphorus-oxygen lyase activity#GO:0016849;cyclase activity#GO:0009975 response to stimulus#GO:0050896;small molecule metabolic process#GO:0044281;signaling#GO:0023052;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521;regulation of biological process#GO:0050789;purine nucleotide metabolic process#GO:0006163;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;nucleotide biosynthetic process#GO:0009165;ribonucleotide metabolic process#GO:0009259;G protein-coupled receptor signaling pathway#GO:0007186;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;cyclic nucleotide biosynthetic process#GO:0009190;ribose phosphate biosynthetic process#GO:0046390;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;signal transduction#GO:0007165;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;metabolic process#GO:0008152;cyclic purine nucleotide metabolic process#GO:0052652;regulation of cellular process#GO:0050794;nucleoside phosphate metabolic process#GO:0006753;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;organophosphate biosynthetic process#GO:0090407;cell communication#GO:0007154;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;carbohydrate derivative metabolic process#GO:1901135;nucleoside phosphate biosynthetic process#GO:1901293;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cyclic nucleotide metabolic process#GO:0009187 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 adenylate cyclase#PC00043 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>cAMP cyclase#P00719;Endothelin signaling pathway#P00019>Adenylate cyclase#P00569 HUMAN|HGNC=20262|UniProtKB=Q8IX90 Q8IX90 SKA3 PTHR48118:SF2 SPINDLE AND KINETOCHORE-ASSOCIATED PROTEIN 3 SPINDLE AND KINETOCHORE-ASSOCIATED PROTEIN 3 chromosome segregation#GO:0007059;cell cycle process#GO:0022402;cellular process#GO:0009987;cell cycle#GO:0007049;mitotic cell cycle#GO:0000278 condensed chromosome, centromeric region#GO:0000779;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;chromosome, centromeric region#GO:0000775;cytoskeleton#GO:0005856;condensed chromosome#GO:0000793;spindle#GO:0005819;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;outer kinetochore#GO:0000940;kinetochore#GO:0000776;chromosome#GO:0005694;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;spindle microtubule#GO:0005876;microtubule#GO:0005874 HUMAN|HGNC=11246|UniProtKB=O43278 O43278 SPINT1 PTHR46750:SF1 KUNITZ-TYPE PROTEASE INHIBITOR 1 KUNITZ-TYPE PROTEASE INHIBITOR 1 peptidase regulator activity#GO:0061134;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;molecular function inhibitor activity#GO:0140678;serine-type endopeptidase inhibitor activity#GO:0004867;enzyme regulator activity#GO:0030234;enzyme inhibitor activity#GO:0004857;molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866 cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;anatomical structure development#GO:0048856;external encapsulating structure organization#GO:0045229;animal gross anatomical part developmental process#GO:0160108;epidermis development#GO:0008544;extracellular structure organization#GO:0043062;developmental process#GO:0032502;epithelium development#GO:0060429;tissue development#GO:0009888;cellular component organization#GO:0016043;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 protein-binding activity modulator#PC00095;protease inhibitor#PC00191 HUMAN|HGNC=25052|UniProtKB=Q96GV9 Q96GV9 MACIR PTHR31224:SF2 UNC119-BINDING PROTEIN C5ORF30 MACROPHAGE IMMUNOMETABOLISM REGULATOR negative regulation of multicellular organismal process#GO:0051241;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;regulation of cell motility#GO:2000145;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of cytokine production#GO:0001817;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of biosynthetic process#GO:0009890;negative regulation of cell motility#GO:2000146;negative regulation of locomotion#GO:0040013;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;regulation of multicellular organismal process#GO:0051239;negative regulation of cell migration#GO:0030336;negative regulation of cellular process#GO:0048523;regulation of cell migration#GO:0030334;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 HUMAN|HGNC=10411|UniProtKB=P62847 P62847 RPS24 PTHR10496:SF7 40S RIBOSOMAL PROTEIN S24 SMALL RIBOSOMAL SUBUNIT PROTEIN ES24 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cytoplasmic translation#GO:0002181;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058;metabolic process#GO:0008152;translation#GO:0006412;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 ribonucleoprotein complex#GO:1990904;cytosolic small ribosomal subunit#GO:0022627;intracellular organelle#GO:0043229;small ribosomal subunit#GO:0015935;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;cytosolic ribosome#GO:0022626;ribosome#GO:0005840;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737 ribosomal protein#PC00202 HUMAN|HGNC=29010|UniProtKB=O15047 O15047 SETD1A PTHR45814:SF3 HISTONE-LYSINE N-METHYLTRANSFERASE SETD1 HISTONE-LYSINE N-METHYLTRANSFERASE SETD1A catalytic activity, acting on a protein#GO:0140096;protein methyltransferase activity#GO:0008276;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring one-carbon groups#GO:0016741;histone H3K4 methyltransferase activity#GO:0042800;lysine N-methyltransferase activity#GO:0016278;histone modifying activity#GO:0140993;histone H3 methyltransferase activity#GO:0140938;histone methyltransferase activity#GO:0042054;protein-lysine N-methyltransferase activity#GO:0016279;N-methyltransferase activity#GO:0008170;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168 protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;nuclear protein-containing complex#GO:0140513;Set1C/COMPASS complex#GO:0048188;transferase complex#GO:1990234;histone methyltransferase complex#GO:0035097;intracellular membrane-bounded organelle#GO:0043231;methyltransferase complex#GO:0034708;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 histone modifying enzyme#PC00261 HUMAN|HGNC=25338|UniProtKB=Q8IYJ0 Q8IYJ0 PIANP PTHR32023:SF2 PILR ALPHA-ASSOCIATED NEURAL PROTEIN PILR ALPHA-ASSOCIATED NEURAL PROTEIN cellular anatomical structure#GO:0110165;membrane#GO:0016020 HUMAN|HGNC=17872|UniProtKB=Q9H993 Q9H993 DCPH1 PTHR12260:SF6 DAMAGE-CONTROL PHOSPHATASE ARMT1 DAMAGE-CONTROL PHOSPHATASE 1 phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578 response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;response to stress#GO:0006950 phosphatase#PC00181;hydrolase#PC00121 HUMAN|HGNC=29846|UniProtKB=O14512 O14512 SOCS7 PTHR10155:SF5 PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT SUPPRESSOR OF CYTOKINE SIGNALING 7 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;signaling adaptor activity#GO:0035591 cell surface receptor signaling pathway#GO:0007166;cellular response to insulin stimulus#GO:0032869;response to chemical#GO:0042221;cellular response to nitrogen compound#GO:1901699;biological regulation#GO:0065007;response to peptide hormone#GO:0043434;response to hormone#GO:0009725;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;response to nitrogen compound#GO:1901698;cellular response to chemical stimulus#GO:0070887;response to oxygen-containing compound#GO:1901700;insulin receptor signaling pathway#GO:0008286;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;regulation of cellular process#GO:0050794;cellular response to hormone stimulus#GO:0032870;signaling#GO:0023052;cellular response to peptide hormone stimulus#GO:0071375;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;response to insulin#GO:0032868;cellular response to stimulus#GO:0051716 kinase modulator#PC00140 Interferon-gamma signaling pathway#P00035>SOCS#P00956;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>SOCS#P00879 HUMAN|HGNC=29866|UniProtKB=O94856 O94856 NFASC PTHR10075:SF113 BASIGIN RELATED NEUROFASCIN cell adhesion molecule#PC00069 HUMAN|HGNC=26861|UniProtKB=Q8N5S3 Q8N5S3 CIMIP6 PTHR35087:SF1 SIMILAR TO HYPOTHETICAL PROTEIN FLJ40298 CILIARY MICROTUBULE INNER PROTEIN 6 HUMAN|HGNC=29510|UniProtKB=Q15390 Q15390 MTFR1 PTHR14215:SF1 PROTEIN OF UNKNOWN FUNCTION DUF729 MITOCHONDRIAL FISSION REGULATOR 1 cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;mitochondrion organization#GO:0007005;mitochondrial fission#GO:0000266;generation of precursor metabolites and energy#GO:0006091;metabolic process#GO:0008152;aerobic respiration#GO:0009060;organelle fission#GO:0048285;cellular respiration#GO:0045333;energy derivation by oxidation of organic compounds#GO:0015980;cellular component organization or biogenesis#GO:0071840 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=4085|UniProtKB=P78334 P78334 GABRE PTHR18945:SF397 NEUROTRANSMITTER GATED ION CHANNEL GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT EPSILON transmembrane signaling receptor activity#GO:0004888;ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;molecular transducer activity#GO:0060089;channel activity#GO:0015267;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;neurotransmitter receptor activity#GO:0030594;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;monoatomic ion channel activity#GO:0005216;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion transmembrane transporter activity#GO:0015075;signaling receptor activity#GO:0038023 chloride transport#GO:0006821;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;synaptic signaling#GO:0099536;nervous system development#GO:0007399;cellular component assembly#GO:0022607;monoatomic anion transmembrane transport#GO:0098656;animal gross anatomical part developmental process#GO:0160108;inorganic anion transport#GO:0015698;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;regulation of biological process#GO:0050789;cell junction assembly#GO:0034329;cellular component organization#GO:0016043;signaling#GO:0023052;synapse assembly#GO:0007416;developmental process#GO:0032502;transport#GO:0006810;establishment of localization#GO:0051234;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;monoatomic ion transmembrane transport#GO:0034220;multicellular organismal process#GO:0032501;synapse organization#GO:0050808;trans-synaptic signaling#GO:0099537;system development#GO:0048731;cell communication#GO:0007154;chloride transmembrane transport#GO:1902476;localization#GO:0051179;anatomical structure development#GO:0048856;monoatomic anion transport#GO:0006820;chemical synaptic transmission#GO:0007268;anterograde trans-synaptic signaling#GO:0098916;cell junction organization#GO:0034330 cell leading edge#GO:0031252;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;plasma membrane region#GO:0098590;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;neuron projection membrane#GO:0032589;signaling receptor complex#GO:0043235;cell junction#GO:0030054;postsynapse#GO:0098794;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;dendrite#GO:0030425;leading edge membrane#GO:0031256;dendritic tree#GO:0097447;cell projection membrane#GO:0031253 ligand-gated ion channel#PC00141 HUMAN|HGNC=3084|UniProtKB=O14640 O14640 DVL1 PTHR10878:SF5 SEGMENT POLARITY PROTEIN DISHEVELLED SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1-RELATED protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102;frizzled binding#GO:0005109;G protein-coupled receptor binding#GO:0001664 signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;Wnt signaling pathway#GO:0016055;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;canonical Wnt signaling pathway#GO:0060070;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 Alzheimer disease-presenilin pathway#P00004>Dsh#P00132;Angiogenesis#P00005>Dsh#P00200;Wnt signaling pathway#P00057>Dishevelled#P01447 HUMAN|HGNC=2651|UniProtKB=P22680 P22680 CYP7A1 PTHR24304:SF1 CYTOCHROME P450 FAMILY 7 CYTOCHROME P450 7A1 monooxygenase activity#GO:0004497;steroid hydroxylase activity#GO:0008395;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen#GO:0016712;oxidoreductase activity#GO:0016491 oxoacid metabolic process#GO:0043436;lipid homeostasis#GO:0055088;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid biosynthetic process#GO:0046394;small molecule metabolic process#GO:0044281;homeostatic process#GO:0042592;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;chemical homeostasis#GO:0048878;small molecule biosynthetic process#GO:0044283;cholesterol homeostasis#GO:0042632;monocarboxylic acid biosynthetic process#GO:0072330;cellular process#GO:0009987;steroid metabolic process#GO:0008202;biosynthetic process#GO:0009058 intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 oxidoreductase#PC00176;oxygenase#PC00177 HUMAN|HGNC=32468|UniProtKB=O75373 O75373 ZNF737 PTHR24384:SF128 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED ZINC FINGER PROTEIN 737 DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218 HUMAN|HGNC=39039|UniProtKB=P63136 P63136 ERVK-25 PTHR41694:SF3 ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN ENDOGENOUS RETROVIRUS GROUP K MEMBER 10 POL PROTEIN-RELATED nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 viral or transposable element protein#PC00237 HUMAN|HGNC=26586|UniProtKB=Q8N2A0 Q8N2A0 LINC00269 PTHR12138:SF133 PRIMATE-EXPANDED PROTEIN FAMILY SECRETED PROTEIN HUMAN|HGNC=10788|UniProtKB=Q13247 Q13247 SRSF6 PTHR23003:SF52 RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN SERINE_ARGININE-RICH SPLICING FACTOR 6 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729 nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 RNA splicing factor#PC00148 HUMAN|HGNC=21169|UniProtKB=Q8IXI1 Q8IXI1 RHOT2 PTHR24072:SF311 RHO FAMILY GTPASE MITOCHONDRIAL RHO GTPASE 2 hydrolase activity#GO:0016787;anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167;GTPase activity#GO:0003924;ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleotide binding#GO:0000166;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;guanyl nucleotide binding#GO:0019001;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;nucleoside phosphate binding#GO:1901265;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;ribonucleotide binding#GO:0032553;hydrolase activity, acting on acid anhydrides#GO:0016817;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367 regulation of cellular process#GO:0050794;actin cytoskeleton organization#GO:0030036;microtubule-based movement#GO:0007018;programmed cell death#GO:0012501;cell death#GO:0008219;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;localization#GO:0051179;supramolecular fiber organization#GO:0097435;organelle localization#GO:0051640;actin filament-based process#GO:0030029;cytoskeleton-dependent intracellular transport#GO:0030705;biological regulation#GO:0065007;regulation of mitochondrial membrane permeability#GO:0046902;transport along microtubule#GO:0010970;establishment of localization#GO:0051234;apoptotic signaling pathway#GO:0097190;mitochondrion localization#GO:0051646;actin filament organization#GO:0007015;intracellular transport#GO:0046907;transport#GO:0006810;establishment of organelle localization#GO:0051656;response to stimulus#GO:0050896;signaling#GO:0023052;cellular component organization#GO:0016043;apoptotic process#GO:0006915;regulation of biological process#GO:0050789;cellular localization#GO:0051641;regulation of biological quality#GO:0065008;microtubule-based transport#GO:0099111;regulation of membrane permeability#GO:0090559;apoptotic mitochondrial changes#GO:0008637;organelle transport along microtubule#GO:0072384;cytoskeleton organization#GO:0007010;mitochondrion organization#GO:0007005;organelle organization#GO:0006996;cellular process#GO:0009987;signal transduction#GO:0007165;establishment of localization in cell#GO:0051649;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017 mitochondrial outer membrane#GO:0005741;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;organelle outer membrane#GO:0031968;plasma membrane#GO:0005886;cytoplasm#GO:0005737;membrane#GO:0016020;mitochondrial membrane#GO:0031966;cell periphery#GO:0071944;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;outer membrane#GO:0019867;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;mitochondrion#GO:0005739 G-protein#PC00020;small GTPase#PC00208 HUMAN|HGNC=42973|UniProtKB=P0DKX4 P0DKX4 SMIM18 PTHR36982:SF1 CLCA DOMAIN-CONTAINING PROTEIN SMALL INTEGRAL MEMBRANE PROTEIN 18 HUMAN|HGNC=8855|UniProtKB=Q92968 Q92968 PEX13 PTHR19332:SF1 PEROXISOMAL MEMBRANE PROTEIN PEX13 PEROXISOMAL MEMBRANE PROTEIN PEX13 protein transport#GO:0015031;peroxisomal transport#GO:0043574;localization#GO:0051179;transmembrane transport#GO:0055085;cellular localization#GO:0051641;peroxisome organization#GO:0007031;protein import into peroxisome matrix#GO:0016558;protein localization to organelle#GO:0033365;cellular component organization#GO:0016043;intracellular protein localization#GO:0008104;cellular component organization or biogenesis#GO:0071840;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;intracellular protein transmembrane transport#GO:0065002;protein transmembrane import into intracellular organelle#GO:0044743;protein transmembrane transport#GO:0071806;intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;organelle organization#GO:0006996;macromolecule localization#GO:0033036 membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;transporter complex#GO:1990351;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;peroxisomal membrane#GO:0005778;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;microbody#GO:0042579;peroxisome#GO:0005777;membrane#GO:0016020 transporter#PC00227;primary active transporter#PC00068 HUMAN|HGNC=55110|UniProtKB=A0A096LPK9 A0A096LPK9 OR4N4C PTHR48002:SF4 OLFACTORY RECEPTOR OLFACTORY RECEPTOR-RELATED olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=27111|UniProtKB=Q86VR7 Q86VR7 VSIG10L PTHR44427:SF5 CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 19 V-SET AND IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN 10-LIKE cell adhesion molecule#PC00069 HUMAN|HGNC=12484|UniProtKB=P62256 P62256 UBE2H PTHR24068:SF128 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2 H transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;ubiquitin conjugating enzyme activity#GO:0061631;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein conjugating enzyme activity#GO:0061650 cellular process#GO:0009987;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;protein modification by small protein conjugation or removal#GO:0070647;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412 ubiquitin-protein ligase#PC00234 Ubiquitin proteasome pathway#P00060>E2#P01491 HUMAN|HGNC=10252|UniProtKB=O75116 O75116 ROCK2 PTHR22988:SF28 MYOTONIC DYSTROPHY S/T KINASE-RELATED RHO-ASSOCIATED PROTEIN KINASE 2 catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 embryo development#GO:0009790;regulation of actin cytoskeleton organization#GO:0032956;intracellular signaling cassette#GO:0141124;cytoskeleton organization#GO:0007010;cellular process#GO:0009987;signal transduction#GO:0007165;organelle organization#GO:0006996;cellular component organization or biogenesis#GO:0071840;embryonic morphogenesis#GO:0048598;multicellular organism development#GO:0007275;regulation of cellular component biogenesis#GO:0044087;signaling#GO:0023052;actomyosin structure organization#GO:0031032;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;cell cycle process#GO:0022402;regulation of organelle organization#GO:0033043;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;Rho protein signal transduction#GO:0007266;cytoskeleton-dependent cytokinesis#GO:0061640;cytokinesis#GO:0000910;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;mitotic cell cycle process#GO:1903047;developmental process#GO:0032502;regulation of actin filament-based process#GO:0032970;mitotic cytokinesis#GO:0000281;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;mitotic cell cycle#GO:0000278;regulation of cytoskeleton organization#GO:0051493;cell division#GO:0051301;cellular response to stimulus#GO:0051716;cell cycle#GO:0007049;intracellular signal transduction#GO:0035556;anatomical structure development#GO:0048856;cortical actin cytoskeleton organization#GO:0030866;cell communication#GO:0007154;regulation of cell junction assembly#GO:1901888;actin filament-based process#GO:0030029;cortical cytoskeleton organization#GO:0030865 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 Cytoskeletal regulation by Rho GTPase#P00016>ROCK#P00519 HUMAN|HGNC=17937|UniProtKB=Q86UP6 Q86UP6 CUZD1 PTHR14002:SF27 ENDOGLIN/TGF-BETA RECEPTOR TYPE III CUB AND ZONA PELLUCIDA-LIKE DOMAIN-CONTAINING PROTEIN 1 extracellular region#GO:0005576;cell surface#GO:0009986;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=18718|UniProtKB=Q8WU67 Q8WU67 ABHD3 PTHR10794:SF50 ABHYDROLASE DOMAIN-CONTAINING PROTEIN PHOSPHOLIPASE ABHD3 hydrolase activity#GO:0016787;lipase activity#GO:0016298;carboxylic ester hydrolase activity#GO:0052689;A2-type glycerophospholipase activity#GO:0004623;glycerophospholipase activity#GO:0004620;catalytic activity#GO:0003824;phospholipase activity#GO:0120569;hydrolase activity, acting on ester bonds#GO:0016788 monocarboxylic acid biosynthetic process#GO:0072330;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;biosynthetic process#GO:0009058;fatty acid biosynthetic process#GO:0006633;lipid biosynthetic process#GO:0008610;monocarboxylic acid catabolic process#GO:0072329;glycerophospholipid metabolic process#GO:0006650;phosphatidylcholine metabolic process#GO:0046470;cellular process#GO:0009987;lipid catabolic process#GO:0016042;carboxylic acid catabolic process#GO:0046395;organophosphate metabolic process#GO:0019637;fatty acid catabolic process#GO:0009062;oxoacid metabolic process#GO:0043436;small molecule catabolic process#GO:0044282;phospholipid metabolic process#GO:0006644;small molecule metabolic process#GO:0044281;glycerolipid metabolic process#GO:0046486;catabolic process#GO:0009056;carboxylic acid biosynthetic process#GO:0046394;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787 protease#PC00190;serine protease#PC00203 HUMAN|HGNC=25480|UniProtKB=Q9NWC5 Q9NWC5 TMEM45A PTHR16007:SF21 EPIDIDYMAL MEMBRANE PROTEIN E9-RELATED TRANSMEMBRANE PROTEIN 45A HUMAN|HGNC=13867|UniProtKB=Q96B97 Q96B97 SH3KBP1 PTHR14167:SF6 SH3 DOMAIN-CONTAINING SH3 DOMAIN-CONTAINING KINASE-BINDING PROTEIN 1 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 scaffold/adaptor protein#PC00226 HUMAN|HGNC=10336|UniProtKB=P62910 P62910 RPL32 PTHR23413:SF6 60S RIBOSOMAL PROTEIN L32 AND DNA-DIRECTED RNA POLYMERASE II, SUBUNIT N LARGE RIBOSOMAL SUBUNIT PROTEIN EL32 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625;cytosol#GO:0005829;ribosome#GO:0005840 ribosomal protein#PC00202 HUMAN|HGNC=28161|UniProtKB=Q9BV47 Q9BV47 DUSP26 PTHR45682:SF8 AGAP008228-PA DUAL SPECIFICITY PROTEIN PHOSPHATASE 26 phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;protein tyrosine/serine/threonine phosphatase activity#GO:0008138;catalytic activity#GO:0003824 negative regulation of signal transduction#GO:0009968;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of response to stimulus#GO:0048585;regulation of response to stimulus#GO:0048583;regulation of MAPK cascade#GO:0043408;negative regulation of cellular process#GO:0048523;negative regulation of MAPK cascade#GO:0043409;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protein phosphatase#PC00195 Oxidative stress response#P00046>MKP5#P01131 HUMAN|HGNC=18654|UniProtKB=Q86VV8 Q86VV8 RTTN PTHR31691:SF1 ROTATIN ROTATIN centrosome duplication#GO:0051298;microtubule-based process#GO:0007017;microtubule organizing center organization#GO:0031023;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cilium organization#GO:0044782;microtubule cytoskeleton organization#GO:0000226;centriole replication#GO:0007099;organelle assembly#GO:0070925;cell projection organization#GO:0030030;cell cycle process#GO:0022402;centrosome cycle#GO:0007098;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;cell cycle#GO:0007049 plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;centriole#GO:0005814;cellular anatomical structure#GO:0110165;organelle#GO:0043226;microtubule cytoskeleton#GO:0015630;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;cilium#GO:0005929;intracellular organelle#GO:0043229;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815 HUMAN|HGNC=42787|UniProtKB=P0DPH9 P0DPH9 CXorf51B PTHR37876:SF1 PROTEIN GAR2-LIKE SPERMATID NUCLEAR TRANSITION PROTEIN 4 HUMAN|HGNC=33518|UniProtKB=Q96QU4 Q96QU4 FRG2B PTHR31883:SF7 PROTEIN FRG2-RELATED PROTEIN FRG2-RELATED HUMAN|HGNC=19960|UniProtKB=Q9BVV6 Q9BVV6 KIAA0586 PTHR15721:SF2 KIAA0586 PROTEIN PROTEIN TALPID3 cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782;organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031;cell projection organization#GO:0030030;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;cilium assembly#GO:0060271;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cell projection assembly#GO:0030031 intracellular organelle#GO:0043229;cilium#GO:0005929;centrosome#GO:0005813;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;ciliary basal body#GO:0036064;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=25756|UniProtKB=Q969M1 Q969M1 TOMM40L PTHR10802:SF0 MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40 MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40B transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;transmembrane protein transporter activity#GO:0008320 establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule localization#GO:0033036;mitochondrial protein import pathway#GO:7770058;protein import into mitochondrial matrix#GO:0030150;protein transmembrane import into intracellular organelle#GO:0044743;protein transmembrane transport#GO:0071806;transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;establishment of protein localization to organelle#GO:0072594;intracellular protein transmembrane transport#GO:0065002;establishment of localization#GO:0051234;protein localization to mitochondrion#GO:0070585;mitochondrial transport#GO:0006839;protein localization to organelle#GO:0033365;mitochondrial transmembrane transport#GO:1990542;protein transport#GO:0015031;localization#GO:0051179;cellular localization#GO:0051641;transmembrane transport#GO:0055085 cytoplasm#GO:0005737;mitochondrial protein-containing complex#GO:0098798;organelle outer membrane#GO:0031968;protein-containing complex#GO:0032991;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;membrane#GO:0016020;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;mitochondrial outer membrane#GO:0005741;mitochondrial outer membrane translocase complex#GO:0005742;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;membrane protein complex#GO:0098796;organelle envelope#GO:0031967;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;outer membrane#GO:0019867;intracellular organelle#GO:0043229 transporter#PC00227;primary active transporter#PC00068 HUMAN|HGNC=384|UniProtKB=Q04828 Q04828 AKR1C1 PTHR11732:SF165 ALDO/KETO REDUCTASE ALDO-KETO REDUCTASE FAMILY 1 MEMBER C1-RELATED oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;organic acid binding#GO:0043177;binding#GO:0005488;anion binding#GO:0043168;small molecule binding#GO:0036094;carboxylic acid binding#GO:0031406;ion binding#GO:0043167;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;oxidoreductase activity#GO:0016491;alcohol dehydrogenase (NADP+) activity#GO:0008106;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen#GO:0016709;monooxygenase activity#GO:0004497;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 secondary metabolic process#GO:0019748;metabolic process#GO:0008152;alcohol metabolic process#GO:0006066;fatty acid metabolic process#GO:0006631;unsaturated fatty acid metabolic process#GO:0033559;lipid metabolic process#GO:0006629;hormone metabolic process#GO:0042445;icosanoid metabolic process#GO:0006690;steroid metabolic process#GO:0008202;biological regulation#GO:0065007;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;regulation of biological quality#GO:0065008;oxoacid metabolic process#GO:0043436;olefinic compound metabolic process#GO:0120254;prostaglandin metabolic process#GO:0006693;small molecule metabolic process#GO:0044281;monocarboxylic acid metabolic process#GO:0032787;ketone metabolic process#GO:0042180;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;regulation of hormone levels#GO:0010817 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 reductase#PC00198;oxidoreductase#PC00176 HUMAN|HGNC=43863|UniProtKB=Q2VIR3 Q2VIR3 EIF2S3B PTHR42854:SF19 EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED translation factor activity#GO:0180051;binding#GO:0005488;nucleic acid binding#GO:0003676;translation initiation factor activity#GO:0003743;tRNA binding#GO:0000049;RNA binding#GO:0003723 cellular component organization#GO:0016043;primary metabolic process#GO:0044238;protein-containing complex assembly#GO:0065003;cytoplasmic translation#GO:0002181;protein biosynthetic process#GO:0160307;ribonucleoprotein complex biogenesis#GO:0022613;cytoplasmic translational initiation#GO:0002183;translational initiation#GO:0006413;translation#GO:0006412;protein metabolic process#GO:0019538;protein-RNA complex assembly#GO:0022618;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component assembly#GO:0022607;gene expression#GO:0010467;biosynthetic process#GO:0009058;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-RNA complex organization#GO:0071826;protein-containing complex organization#GO:0043933 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 translation initiation factor#PC00224 HUMAN|HGNC=14707|UniProtKB=Q8NGC5 Q8NGC5 OR6J1 PTHR26454:SF53 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 6J1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=31286|UniProtKB=A6NHG9 A6NHG9 OR5H14 PTHR26452:SF96 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5H14 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 nervous system process#GO:0050877;sensory perception#GO:0007600;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=29869|UniProtKB=P98077 P98077 SHC2 PTHR10337:SF5 SHC TRANSFORMING PROTEIN SHC-TRANSFORMING PROTEIN 2 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;biological regulation#GO:0065007;cell surface receptor signaling pathway#GO:0007166;positive regulation of cell population proliferation#GO:0008284;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;enzyme-linked receptor protein signaling pathway#GO:0007167 scaffold/adaptor protein#PC00226 EGF receptor signaling pathway#P00018>Shc#P00554;Angiogenesis#P00005>Sck#P00202;PDGF signaling pathway#P00047>Shc#P01175;VEGF signaling pathway#P00056>Sck#P01424 HUMAN|HGNC=30513|UniProtKB=Q96AH8 Q96AH8 RAB7B PTHR47981:SF22 RAB FAMILY RAS-RELATED PROTEIN RAB-7B hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;molecular function regulator activity#GO:0098772 endocytosis#GO:0006897;vesicle fusion#GO:0006906;cellular component organization#GO:0016043;cellular localization#GO:0051641;localization#GO:0051179;vacuole organization#GO:0007033;organelle assembly#GO:0070925;lysosomal transport#GO:0007041;endosome to lysosome transport#GO:0008333;vesicle-mediated transport#GO:0016192;organelle fusion#GO:0048284;cellular component assembly#GO:0022607;organelle membrane fusion#GO:0090174;membrane organization#GO:0061024;cellular component biogenesis#GO:0044085;membrane fusion#GO:0061025;organelle organization#GO:0006996;lysosome organization#GO:0007040;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of localization#GO:0051234;import into cell#GO:0098657;cellular component organization or biogenesis#GO:0071840;vesicle organization#GO:0016050;phagocytosis#GO:0006909;intracellular transport#GO:0046907;phagolysosome assembly#GO:0001845;transport#GO:0006810;lytic vacuole organization#GO:0080171;vacuolar transport#GO:0007034 lytic vacuole#GO:0000323;phagocytic vesicle#GO:0045335;endomembrane system#GO:0012505;late endosome#GO:0005770;cytoplasm#GO:0005737;vacuole#GO:0005773;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;endocytic vesicle#GO:0030139;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;lysosome#GO:0005764;vesicle#GO:0031982 small GTPase#PC00208 HUMAN|HGNC=20494|UniProtKB=Q5H9T9 Q5H9T9 FSCB PTHR36135:SF1 FIBROUS SHEATH CABYR-BINDING PROTEIN FIBROUS SHEATH CABYR-BINDING PROTEIN small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;calcium ion binding#GO:0005509;metal ion binding#GO:0046872;cation binding#GO:0043169 negative regulation of cellular process#GO:0048523;regulation of post-translational protein modification#GO:1901873;regulation of protein modification process#GO:0031399;regulation of metabolic process#GO:0019222;regulation of protein modification by small protein conjugation or removal#GO:1903320;regulation of protein metabolic process#GO:0051246;regulation of primary metabolic process#GO:0080090;negative regulation of biological process#GO:0048519;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of protein metabolic process#GO:0051248;biological regulation#GO:0065007;negative regulation of metabolic process#GO:0009892 sperm principal piece#GO:0097228;motile cilium#GO:0031514;organelle#GO:0043226;cellular anatomical structure#GO:0110165;sperm flagellum#GO:0036126;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cilium#GO:0005929;9+2 motile cilium#GO:0097729;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=1696|UniProtKB=P21854 P21854 CD72 PTHR15028:SF10 CD72-RELATED B-CELL DIFFERENTIATION ANTIGEN CD72 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;negative regulation of response to stimulus#GO:0048585;regulation of signal transduction#GO:0009966;negative regulation of immune system process#GO:0002683;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;negative regulation of signaling#GO:0023057;regulation of immune response#GO:0050776;regulation of signaling#GO:0023051;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of B cell receptor signaling pathway#GO:0050855;regulation of cell communication#GO:0010646 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=10860|UniProtKB=P15907 P15907 ST6GAL1 PTHR46059:SF2 BETA-GALACTOSIDE ALPHA-2,6-SIALYLTRANSFERASE BETA-GALACTOSIDE ALPHA-2,6-SIALYLTRANSFERASE 1 transferase activity#GO:0016740;catalytic activity#GO:0003824;sialyltransferase activity#GO:0008373;glycosyltransferase activity#GO:0016757 protein N-linked glycosylation#GO:0006487;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;biosynthetic process#GO:0009058;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;macromolecule modification#GO:0043412;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 transferase#PC00220;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=24301|UniProtKB=Q9NPA0 Q9NPA0 EMC7 PTHR13605:SF4 ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7 ENDOPLASMIC RETICULUM MEMBRANE PROTEIN COMPLEX SUBUNIT 7 endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;membrane#GO:0016020;organelle membrane#GO:0031090;endoplasmic reticulum protein-containing complex#GO:0140534;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;EMC complex#GO:0072546;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229 HUMAN|HGNC=24263|UniProtKB=Q9Y3E2 Q9Y3E2 BOLA1 PTHR46229:SF2 BOLA TRANSCRIPTION REGULATOR BOLA-LIKE PROTEIN 1 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HUMAN|HGNC=6246|UniProtKB=Q9H3M0 Q9H3M0 KCNF1 PTHR11537:SF171 VOLTAGE-GATED POTASSIUM CHANNEL VOLTAGE-GATED POTASSIUM CHANNEL REGULATORY SUBUNIT KCNF1 potassium channel regulator activity#GO:0015459;transporter regulator activity#GO:0141108;ion channel regulator activity#GO:0099106;channel regulator activity#GO:0016247;molecular function regulator activity#GO:0098772 monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;action potential#GO:0001508;metal ion transport#GO:0030001;transport#GO:0006810;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813 transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797 voltage-gated ion channel#PC00241;ion channel#PC00133 HUMAN|HGNC=9454|UniProtKB=O43490 O43490 PROM1 PTHR22730:SF3 PROMININ PROM PROTEIN PROMININ-1 animal gross anatomical part developmental process#GO:0160108;camera-type eye development#GO:0043010;generation of neurons#GO:0048699;anatomical structure development#GO:0048856;eye development#GO:0001654;system development#GO:0048731;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;sensory organ morphogenesis#GO:0090596;animal organ morphogenesis#GO:0009887;cell differentiation#GO:0030154;cell projection organization#GO:0030030;visual system development#GO:0150063;sensory organ development#GO:0007423;neuron differentiation#GO:0030182;developmental process#GO:0032502;animal organ development#GO:0048513;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;neurogenesis#GO:0022008;camera-type eye morphogenesis#GO:0048593;sensory system development#GO:0048880;cellular process#GO:0009987;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;nervous system development#GO:0007399;retina development in camera-type eye#GO:0060041 cytoskeleton#GO:0005856;apical part of cell#GO:0045177;membraneless organelle#GO:0043228;membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane region#GO:0098590;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;extracellular region#GO:0005576;intracellular organelle#GO:0043229;cilium#GO:0005929;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;actin cytoskeleton#GO:0015629;apical plasma membrane#GO:0016324;actin-based cell projection#GO:0098858;microvillus#GO:0005902;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995 HUMAN|HGNC=13069|UniProtKB=Q9NSD4 Q9NSD4 ZNF275 PTHR23226:SF409 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER PROTEIN 275 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690 regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=6801|UniProtKB=P43357 P43357 MAGEA3 PTHR11736:SF60 MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN MELANOMA-ASSOCIATED ANTIGEN 3-RELATED histone deacetylase binding#GO:0042826;protein binding#GO:0005515;binding#GO:0005488;enzyme binding#GO:0019899 negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 scaffold/adaptor protein#PC00226 HUMAN|HGNC=6065|UniProtKB=P05111 P05111 INHA PTHR11848:SF117 TGF-BETA FAMILY INHIBIN ALPHA CHAIN signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;signaling receptor regulator activity#GO:0030545;cytokine activity#GO:0005125;receptor ligand activity#GO:0048018 biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 growth factor#PC00112 Gonadotropin-releasing hormone receptor pathway#P06664>Inha#P06855 HUMAN|HGNC=19082|UniProtKB=Q8IZF0 Q8IZF0 NALCN PTHR46141:SF1 SODIUM LEAK CHANNEL NON-SELECTIVE PROTEIN SODIUM LEAK CHANNEL NALCN monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic cation channel activity#GO:0005261 regulation of biological process#GO:0050789;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;modulation of chemical synaptic transmission#GO:0050804;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;positive regulation of cell communication#GO:0010647;regulation of trans-synaptic signaling#GO:0099177;regulation of cellular process#GO:0050794;regulation of signaling#GO:0023051;positive regulation of synaptic transmission#GO:0050806;positive regulation of signaling#GO:0023056 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133 HUMAN|HGNC=6192|UniProtKB=O60674 O60674 JAK2 PTHR45807:SF1 TYROSINE-PROTEIN KINASE HOPSCOTCH TYROSINE-PROTEIN KINASE JAK2 protein binding#GO:0005515;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;binding#GO:0005488;cytokine receptor binding#GO:0005126;signaling receptor binding#GO:0005102;hormone receptor binding#GO:0051427;non-membrane spanning protein tyrosine kinase activity#GO:0004715;catalytic activity, acting on a protein#GO:0140096;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 immune response#GO:0006955;response to tumor necrosis factor#GO:0034612;response to peptide hormone#GO:0043434;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;multicellular organismal-level homeostasis#GO:0048871;defense response#GO:0006952;innate immune response#GO:0045087;cellular response to stimulus#GO:0051716;cellular response to chemokine#GO:1990869;regulation of cellular process#GO:0050794;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cytokine-mediated signaling pathway#GO:0019221;anatomical structure development#GO:0048856;chemokine-mediated signaling pathway#GO:0070098;response to type II interferon#GO:0034341;cellular process#GO:0009987;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;defense response to symbiont#GO:0140546;response to chemokine#GO:1990868;response to biotic stimulus#GO:0009607;cell surface receptor signaling pathway via STAT#GO:0097696;defense response to other organism#GO:0098542;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;cell development#GO:0048468;cellular response to hormone stimulus#GO:0032870;myeloid cell differentiation#GO:0030099;response to stimulus#GO:0050896;G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887;immune system process#GO:0002376;response to other organism#GO:0051707;hemopoiesis#GO:0030097;cellular response to nitrogen compound#GO:1901699;cell surface receptor signaling pathway via JAK-STAT#GO:0007259;developmental process#GO:0032502;response to external stimulus#GO:0009605;cellular developmental process#GO:0048869;cellular response to peptide hormone stimulus#GO:0071375;homeostatic process#GO:0042592;response to external biotic stimulus#GO:0043207;homeostasis of number of cells#GO:0048872;intracellular signal transduction#GO:0035556;response to nitrogen compound#GO:1901698;enzyme-linked receptor protein signaling pathway#GO:0007167;erythrocyte differentiation#GO:0030218;tumor necrosis factor-mediated signaling pathway#GO:0033209;cell communication#GO:0007154;response to hormone#GO:0009725;response to stress#GO:0006950;response to chemical#GO:0042221;response to cytokine#GO:0034097;cell surface receptor signaling pathway#GO:0007166;regulation of apoptotic process#GO:0042981;regulation of programmed cell death#GO:0043067;response to endogenous stimulus#GO:0009719;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;cell differentiation#GO:0030154;cellular response to endogenous stimulus#GO:0071495;response to oxygen-containing compound#GO:1901700;response to peptide#GO:1901652 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 non-receptor tyrosine protein kinase#PC00168 PDGF signaling pathway#P00047>Jak#P01155;PI3 kinase pathway#P00048>JAK#P01176;CCKR signaling map#P06959>JAK2#P07156;Interferon-gamma signaling pathway#P00035>Jak2#P00952;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>JAK#P00846;JAK/STAT signaling pathway#P00038>Jak#P01034 HUMAN|HGNC=12597|UniProtKB=Q9Y6N9 Q9Y6N9 USH1C PTHR23116:SF36 PDZ DOMAIN CONTAINING WHIRLIN AND HARMONIN-RELATED HARMONIN neuron projection development#GO:0031175;inner ear development#GO:0048839;cellular process#GO:0009987;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;sensory organ development#GO:0007423;neuron differentiation#GO:0030182;developmental process#GO:0032502;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;animal organ development#GO:0048513;system process#GO:0003008;neurogenesis#GO:0022008;inner ear receptor cell stereocilium organization#GO:0060122;cellular component organization#GO:0016043;sensory perception of sound#GO:0007605;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell development#GO:0048468;animal gross anatomical part developmental process#GO:0160108;sensory perception#GO:0007600;sensory perception of mechanical stimulus#GO:0050954;generation of neurons#GO:0048699;nervous system process#GO:0050877;anatomical structure development#GO:0048856;system development#GO:0048731;neuron development#GO:0048666;ear development#GO:0043583 membraneless organelle#GO:0043228;stereocilium#GO:0032420;cytoskeleton#GO:0005856;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;membrane-bounded organelle#GO:0043227;cluster of actin-based cell projections#GO:0098862;intracellular anatomical structure#GO:0005622;photoreceptor inner segment#GO:0001917;cilium#GO:0005929;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;actin cytoskeleton#GO:0015629;actin-based cell projection#GO:0098858 cytoskeletal protein#PC00085 HUMAN|HGNC=12205|UniProtKB=A0A075B6N4 A0A075B6N4 TRBV25-1 PTHR23268:SF30 T-CELL RECEPTOR BETA CHAIN T CELL RECEPTOR BETA CHAIN MC.7.G5-RELATED signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=23428|UniProtKB=Q8TAT2 Q8TAT2 FGFBP3 PTHR15258:SF3 FGF BINDING PROTEIN-RELATED FIBROBLAST GROWTH FACTOR-BINDING PROTEIN 3 binding#GO:0005488;protein binding#GO:0005515;growth factor binding#GO:0019838 signaling#GO:0023052;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;cell communication#GO:0007154;regulation of biological process#GO:0050789;cellular process#GO:0009987 HUMAN|HGNC=15646|UniProtKB=Q8IXQ5 Q8IXQ5 KLHL7 PTHR24412:SF435 KELCH PROTEIN KELCH-LIKE PROTEIN 7 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;enzyme-substrate adaptor activity#GO:0140767;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511 transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;Cul3-RING ubiquitin ligase complex#GO:0031463;ubiquitin ligase complex#GO:0000151;cullin-RING ubiquitin ligase complex#GO:0031461;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=19679|UniProtKB=Q2M2I8 Q2M2I8 AAK1 PTHR47907:SF3 PROTEIN KINASE DOMAIN-CONTAINING PROTEIN AP2-ASSOCIATED PROTEIN KINASE 1 protein serine/threonine kinase activity#GO:0004674;binding#GO:0005488;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein-containing complex binding#GO:0044877;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096 regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of receptor-mediated endocytosis#GO:0048259;biological regulation#GO:0065007;regulation of endocytosis#GO:0030100;regulation of transport#GO:0051049;regulation of localization#GO:0032879 presynapse#GO:0098793;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell junction#GO:0030054 HUMAN|HGNC=7960|UniProtKB=P51843 P51843 NR0B1 PTHR24081:SF1 NUCLEAR RECEPTOR SUBFAMILY 0 GROUP B NUCLEAR RECEPTOR SUBFAMILY 0 GROUP B MEMBER 1 RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629;protein binding#GO:0005515;DNA-binding transcription factor binding#GO:0140297;binding#GO:0005488;transcription regulator activity#GO:0140110;nuclear receptor binding#GO:0016922;transcription factor binding#GO:0008134;transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712 negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;gamete generation#GO:0007276;regulation of transcription by RNA polymerase II#GO:0006357;reproductive structure development#GO:0048608;negative regulation of metabolic process#GO:0009892;animal gross anatomical part developmental process#GO:0160108;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of macromolecule biosynthetic process#GO:0010558;sex differentiation#GO:0007548;male gonad development#GO:0008584;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;development of primary sexual characteristics#GO:0045137;animal organ development#GO:0048513;multicellular organism development#GO:0007275;developmental process involved in reproduction#GO:0003006;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;reproductive process#GO:0022414;sexual reproduction#GO:0019953;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of RNA metabolic process#GO:0051252;multicellular organismal reproductive process#GO:0048609;reproductive system development#GO:0061458;negative regulation of transcription by RNA polymerase II#GO:0000122;system development#GO:0048731;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;multicellular organismal process#GO:0032501;male gamete generation#GO:0048232;regulation of nucleobase-containing compound metabolic process#GO:0019219;gonad development#GO:0008406;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;negative regulation of cellular process#GO:0048523;development of primary male sexual characteristics#GO:0046546;male sex differentiation#GO:0046661;spermatogenesis#GO:0007283;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;C4 zinc finger nuclear receptor#PC00169 HUMAN|HGNC=12412|UniProtKB=Q13885 Q13885 TUBB2A PTHR11588:SF100 TUBULIN TUBULIN BETA-2A CHAIN structural molecule activity#GO:0005198;nucleotide binding#GO:0000166;anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;ribonucleotide binding#GO:0032553;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;carbohydrate derivative binding#GO:0097367;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;guanyl nucleotide binding#GO:0019001;binding#GO:0005488;structural constituent of cytoskeleton#GO:0005200;nucleoside phosphate binding#GO:1901265 multicellular organismal process#GO:0032501;cell migration#GO:0016477;nervous system development#GO:0007399;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular process#GO:0009987;cellular developmental process#GO:0048869;neuron migration#GO:0001764;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;neurogenesis#GO:0022008;developmental process#GO:0032502;cell motility#GO:0048870;mitotic cell cycle#GO:0000278;cell differentiation#GO:0030154;cellular component organization#GO:0016043;cell cycle#GO:0007049;microtubule cytoskeleton organization#GO:0000226;anatomical structure development#GO:0048856;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699 microtubule cytoskeleton#GO:0015630;organelle#GO:0043226;supramolecular complex#GO:0099080;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;microtubule#GO:0005874;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622 cytoskeletal protein#PC00085;tubulin#PC00228 Huntington disease#P00029>beta-Tubulin#P00790;Huntington disease#P00029>Microtubule#P00780;Cytoskeletal regulation by Rho GTPase#P00016>tubulin#P00526 HUMAN|HGNC=8548|UniProtKB=P07237 P07237 P4HB PTHR18929:SF101 PROTEIN DISULFIDE ISOMERASE PROTEIN DISULFIDE-ISOMERASE catalytic activity#GO:0003824;protein disulfide isomerase activity#GO:0003756;intramolecular oxidoreductase activity#GO:0016860;catalytic activity, acting on a protein#GO:0140096;isomerase activity#GO:0016853 metabolic process#GO:0008152;response to endoplasmic reticulum stress#GO:0034976;cellular response to stress#GO:0033554;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;response to stress#GO:0006950;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;response to stimulus#GO:0050896;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;protein folding#GO:0006457 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;external side of plasma membrane#GO:0009897;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;side of membrane#GO:0098552 chaperone#PC00072 HUMAN|HGNC=16128|UniProtKB=Q9H3Z7 Q9H3Z7 ABHD16B PTHR12277:SF37 ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN ABHD16B hydrolase activity#GO:0016787;glycerophospholipase activity#GO:0004620;catalytic activity#GO:0003824;lipase activity#GO:0016298;phospholipase activity#GO:0120569;hydrolase activity, acting on ester bonds#GO:0016788;carboxylic ester hydrolase activity#GO:0052689 glycerolipid catabolic process#GO:0046503;organophosphate catabolic process#GO:0046434;phosphorus metabolic process#GO:0006793;modified amino acid metabolic process#GO:0006575;primary metabolic process#GO:0044238;phospholipid metabolic process#GO:0006644;phospholipid catabolic process#GO:0009395;glycerolipid metabolic process#GO:0046486;catabolic process#GO:0009056;neutral lipid catabolic process#GO:0046461;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;acylglycerol metabolic process#GO:0006639;acylglycerol catabolic process#GO:0046464;neutral lipid metabolic process#GO:0006638;glycerophospholipid catabolic process#GO:0046475;lipid catabolic process#GO:0016042;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;glycerophospholipid metabolic process#GO:0006650 serine protease#PC00203 HUMAN|HGNC=2312|UniProtKB=P15169 P15169 CPN1 PTHR11532:SF80 PROTEASE M14 CARBOXYPEPTIDASE CARBOXYPEPTIDASE N CATALYTIC CHAIN metallopeptidase activity#GO:0008237;exopeptidase activity#GO:0008238;hydrolase activity#GO:0016787;metallocarboxypeptidase activity#GO:0004181;carboxypeptidase activity#GO:0004180;catalytic activity#GO:0003824;metalloexopeptidase activity#GO:0008235;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233 gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein processing#GO:0016485;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;peptide metabolic process#GO:0006518;metabolic process#GO:0008152;proteolysis#GO:0006508 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease#PC00190 HUMAN|HGNC=2190|UniProtKB=Q5TAT6 Q5TAT6 COL13A1 PTHR24023:SF871 COLLAGEN ALPHA COLLAGEN ALPHA-1(XIII) CHAIN structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;external encapsulating structure organization#GO:0045229;extracellular structure organization#GO:0043062;cellular component organization#GO:0016043;cellular process#GO:0009987 external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;basement membrane#GO:0005604;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 extracellular matrix structural protein#PC00103;extracellular matrix protein#PC00102 Integrin signalling pathway#P00034>Collagen#P00922 HUMAN|HGNC=12933|UniProtKB=Q9UQR1 Q9UQR1 ZNF148 PTHR24404:SF53 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 148 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 DNA-binding transcription factor#PC00218;C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HUMAN|HGNC=13806|UniProtKB=Q9Y4Z2 Q9Y4Z2 NEUROG3 PTHR19290:SF94 BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED NEUROGENIN-3 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700 generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;neuron development#GO:0048666;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;cell development#GO:0048468;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;cell projection organization#GO:0030030;neuron differentiation#GO:0030182;positive regulation of transcription by RNA polymerase II#GO:0045944;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;animal organ development#GO:0048513;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;neuron projection development#GO:0031175;nervous system development#GO:0007399;positive regulation of macromolecule metabolic process#GO:0010604;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;developmental process#GO:0032502;sensory organ development#GO:0007423;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;axon development#GO:0061564;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;plasma membrane bounded cell projection organization#GO:0120036;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;positive regulation of DNA-templated transcription#GO:0045893 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=11280|UniProtKB=Q13501 Q13501 SQSTM1 PTHR15090:SF0 SEQUESTOSOME 1-RELATED SEQUESTOSOME-1 K63-linked polyubiquitin modification-dependent protein binding#GO:0070530;polyubiquitin modification-dependent protein binding#GO:0031593;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;kinase binding#GO:0019900;binding#GO:0005488;modification-dependent protein binding#GO:0140030;protein binding#GO:0005515 catabolic process#GO:0009056;endomembrane system organization#GO:0010256;macroautophagy#GO:0016236;organelle organization#GO:0006996;cellular component organization#GO:0016043;autophagy#GO:0006914;cellular process#GO:0009987;mitophagy#GO:0000423;cellular component organization or biogenesis#GO:0071840;process utilizing autophagic mechanism#GO:0061919;vesicle organization#GO:0016050;endosome organization#GO:0007032;metabolic process#GO:0008152;autophagy of mitochondrion#GO:0000422 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;autophagosome#GO:0005776;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;vacuole#GO:0005773 HUMAN|HGNC=377|UniProtKB=Q9P0M2 Q9P0M2 AKAP7 PTHR15934:SF6 RNA 2',3'-CYCLIC PHOSPHODIESTERASE A-KINASE ANCHOR PROTEIN 7 ISOFORM GAMMA protein binding#GO:0005515;protein kinase A regulatory subunit binding#GO:0034237;protein kinase A binding#GO:0051018;binding#GO:0005488 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HUMAN|HGNC=2155|UniProtKB=P51911 P51911 CNN1 PTHR47385:SF12 CALPONIN CALPONIN-1 protein-containing complex binding#GO:0044877;protein binding#GO:0005515;actin filament binding#GO:0051015;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;binding#GO:0005488 cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;actin filament-based process#GO:0030029;actin filament organization#GO:0007015;supramolecular fiber organization#GO:0097435;cellular component organization or biogenesis#GO:0071840 intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165;actin cytoskeleton#GO:0015629;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 HUMAN|HGNC=26941|UniProtKB=Q9Y3C8 Q9Y3C8 UFC1 PTHR12921:SF0 UBIQUITIN-FOLD MODIFIER-CONJUGATING ENZYME 1 UBIQUITIN-FOLD MODIFIER-CONJUGATING ENZYME 1 ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 metabolic process#GO:0008152;response to endoplasmic reticulum stress#GO:0034976;cellular response to stress#GO:0033554;process utilizing autophagic mechanism#GO:0061919;reticulophagy#GO:0061709;response to stress#GO:0006950;autophagy#GO:0006914;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;catabolic process#GO:0009056;macroautophagy#GO:0016236 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=13516|UniProtKB=Q9NR09 Q9NR09 BIRC6 PTHR46116:SF39 (E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME DUAL E2 UBIQUITIN-CONJUGATING ENZYME_E3 UBIQUITIN-PROTEIN LIGASE BIRC6 acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-like protein conjugating enzyme activity#GO:0061650;ubiquitin-protein transferase activity#GO:0004842;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin conjugating enzyme activity#GO:0061631;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 biological regulation#GO:0065007;negative regulation of apoptotic process#GO:0043066;regulation of cellular process#GO:0050794;negative regulation of programmed cell death#GO:0043069;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;regulation of apoptotic process#GO:0042981;negative regulation of cellular process#GO:0048523 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=7849|UniProtKB=P15531 P15531 NME1 PTHR11349:SF69 NUCLEOSIDE DIPHOSPHATE KINASE NUCLEOSIDE DIPHOSPHATE KINASE A transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;nucleobase-containing compound kinase activity#GO:0019205;transferase activity#GO:0016740;phosphotransferase activity, phosphate group as acceptor#GO:0016776;nucleoside diphosphate kinase activity#GO:0004550 cellular process#GO:0009987;metabolic process#GO:0008152;phosphorus metabolic process#GO:0006793;nucleoside triphosphate biosynthetic process#GO:0009142;biosynthetic process#GO:0009058;nucleoside triphosphate metabolic process#GO:0009141 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739 transferase#PC00220;kinase#PC00137 De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>dTDP kinase#P02919;De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>dCDP kinase#P02914;De novo purine biosynthesis#P02738>dGDP kinase#P02889;De novo pyrimidine ribonucleotides biosythesis#P02740>CDP kinase#P02929;De novo purine biosynthesis#P02738>dADP kinase#P02907;De novo pyrimidine ribonucleotides biosythesis#P02740>UDP kinase#P02923;De novo purine biosynthesis#P02738>GDP kinase#P02891;De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>dUDP kinase#P02912 HUMAN|HGNC=6392|UniProtKB=Q02241 Q02241 KIF23 PTHR24115:SF600 KINESIN-RELATED KINESIN-LIKE PROTEIN KIF23 protein binding#GO:0005515;ATP-dependent activity#GO:0140657;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;cytoskeletal motor activity#GO:0003774;hydrolase activity, acting on acid anhydrides#GO:0016817;cytoskeletal protein binding#GO:0008092;microtubule motor activity#GO:0003777;ATP hydrolysis activity#GO:0016887;hydrolase activity#GO:0016787;polypeptide conformation or assembly isomerase activity#GO:0120544;microtubule binding#GO:0008017;isomerase activity#GO:0016853;ribonucleoside triphosphate phosphatase activity#GO:0017111;tubulin binding#GO:0015631;macromolecular conformation isomerase activity#GO:0120543;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462 cellular component organization or biogenesis#GO:0071840;spindle organization#GO:0007051;microtubule-based process#GO:0007017;chromosome organization#GO:0051276;mitotic cell cycle process#GO:1903047;chromosome segregation#GO:0007059;cellular component assembly#GO:0022607;spindle elongation#GO:0051231;cytoskeleton organization#GO:0007010;spindle assembly#GO:0051225;organelle organization#GO:0006996;mitotic sister chromatid segregation#GO:0000070;cellular component biogenesis#GO:0044085;mitotic spindle assembly#GO:0090307;cellular process#GO:0009987;microtubule cytoskeleton organization#GO:0000226;organelle fission#GO:0048285;nuclear division#GO:0000280;organelle assembly#GO:0070925;mitotic spindle organization#GO:0007052;microtubule-based movement#GO:0007018;mitotic cell cycle#GO:0000278;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;microtubule cytoskeleton organization involved in mitosis#GO:1902850;sister chromatid segregation#GO:0000819;nuclear chromosome segregation#GO:0098813;cell cycle#GO:0007049;mitotic nuclear division#GO:0140014;cell cycle process#GO:0022402 microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cytoskeleton#GO:0005856;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;nucleus#GO:0005634 microtubule or microtubule-binding cytoskeletal protein#PC00157;microtubule binding motor protein#PC00156 HUMAN|HGNC=13487|UniProtKB=Q96QK1 Q96QK1 VPS35 PTHR11099:SF0 VACUOLAR SORTING PROTEIN 35 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 35 cargo adaptor activity#GO:0140312;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 localization within membrane#GO:0051668;establishment of protein localization to plasma membrane#GO:0061951;protein transport#GO:0015031;localization#GO:0051179;cellular localization#GO:0051641;protein localization to membrane#GO:0072657;protein localization to plasma membrane#GO:0072659;cytosolic transport#GO:0016482;endocytic recycling#GO:0032456;intracellular protein transport#GO:0006886;transport#GO:0006810;protein localization to cell periphery#GO:1990778;intracellular transport#GO:0046907;vesicle-mediated transport to the plasma membrane#GO:0098876;intracellular protein localization#GO:0008104;endosomal transport#GO:0016197;establishment of localization#GO:0051234;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;endosome to plasma membrane protein transport#GO:0099638;cellular process#GO:0009987;establishment of protein localization to membrane#GO:0090150;retrograde transport, endosome to Golgi#GO:0042147;macromolecule localization#GO:0033036;vesicle-mediated transport#GO:0016192 late endosome#GO:0005770;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;membrane#GO:0016020;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;vesicle#GO:0031982;retromer complex#GO:0030904 membrane traffic protein#PC00150 HUMAN|HGNC=28980|UniProtKB=Q14691 Q14691 GINS1 PTHR12914:SF2 PARTNER OF SLD5 DNA REPLICATION COMPLEX GINS PROTEIN PSF1 mitotic cell cycle#GO:0000278;DNA strand elongation involved in DNA replication#GO:0006271;cell cycle#GO:0007049;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cell cycle process#GO:0022402;DNA replication#GO:0006260;DNA-templated DNA replication#GO:0006261;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;mitotic cell cycle process#GO:1903047;cell cycle DNA replication#GO:0044786;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;mitotic DNA replication#GO:1902969;nuclear DNA replication#GO:0033260 nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;CMG complex#GO:0071162;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;DNA replication preinitiation complex#GO:0031261;chromosome#GO:0005694;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;GINS complex#GO:0000811;protein-DNA complex#GO:0032993;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031;general transcription factor#PC00259 HUMAN|HGNC=18058|UniProtKB=Q96DR4 Q96DR4 STARD4 PTHR47006:SF1 STAR-RELATED LIPID TRANSFER PROTEIN 4 STAR-RELATED LIPID TRANSFER PROTEIN 4 molecular carrier activity#GO:0140104;sterol binding#GO:0032934;lipid carrier activity#GO:0005319;small molecule binding#GO:0036094;binding#GO:0005488;lipid transfer activity#GO:0120013;cholesterol binding#GO:0015485;lipid binding#GO:0008289;sterol transfer activity#GO:0120015;transporter activity#GO:0005215;steroid binding#GO:0005496;alcohol binding#GO:0043178;cholesterol transfer activity#GO:0120020 lipid transport#GO:0006869;intracellular sterol transport#GO:0032366;cholesterol transport#GO:0030301;macromolecule localization#GO:0033036;cellular process#GO:0009987;lipid storage#GO:0019915;establishment of localization in cell#GO:0051649;cellular localization#GO:0051641;sterol transport#GO:0015918;establishment of localization#GO:0051234;localization#GO:0051179;organic hydroxy compound transport#GO:0015850;intracellular transport#GO:0046907;lipid localization#GO:0010876;transport#GO:0006810 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytosol#GO:0005829;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 HUMAN|HGNC=14705|UniProtKB=Q8NGB4 Q8NGB4 OR4S1 PTHR48002:SF81 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 4S1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=9037|UniProtKB=Q9UP65 Q9UP65 PLA2G4C PTHR10728:SF39 CYTOSOLIC PHOSPHOLIPASE A2 CYTOSOLIC PHOSPHOLIPASE A2 GAMMA hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;phospholipid binding#GO:0005543;cation binding#GO:0043169;hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689;lipase activity#GO:0016298;small molecule binding#GO:0036094;ion binding#GO:0043167;A2-type glycerophospholipase activity#GO:0004623;phospholipase activity#GO:0120569;glycerophospholipase activity#GO:0004620;lipid binding#GO:0008289;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;binding#GO:0005488 glycerolipid catabolic process#GO:0046503;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;organophosphate catabolic process#GO:0046434;glycerophospholipid catabolic process#GO:0046475;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;lipid catabolic process#GO:0016042;glycerophospholipid metabolic process#GO:0006650;catabolic process#GO:0009056;phospholipid catabolic process#GO:0009395;glycerolipid metabolic process#GO:0046486;phospholipid metabolic process#GO:0006644 cytosol#GO:0005829;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;endomembrane system#GO:0012505;nuclear envelope#GO:0005635;cytoplasm#GO:0005737;organelle envelope#GO:0031967;organelle lumen#GO:0043233;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 phospholipase#PC00186 Gonadotropin-releasing hormone receptor pathway#P06664>PLA2#P06738;Angiogenesis#P00005>cPLA2#P00251 HUMAN|HGNC=6304|UniProtKB=P24390 P24390 KDELR1 PTHR10585:SF61 ER LUMEN PROTEIN RETAINING RECEPTOR ER LUMEN PROTEIN-RETAINING RECEPTOR 1 signal sequence receptor activity#GO:0005048 intracellular protein localization#GO:0008104;protein localization to organelle#GO:0033365;cellular localization#GO:0051641;localization#GO:0051179;cellular process#GO:0009987;macromolecule localization#GO:0033036 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;cis-Golgi network#GO:0005801;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794 membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=34404|UniProtKB=Q1ED39 Q1ED39 KNOP1 PTHR22426:SF4 ARGININE_SERINE-RICH COILED-COIL PROTEIN 2 LYSINE-RICH NUCLEOLAR PROTEIN 1 HUMAN|HGNC=5855|UniProtKB=P0CG04 P0CG04 IGLC1 PTHR23266:SF310 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN LAMBDA CONSTANT 1-RELATED binding#GO:0005488;antigen binding#GO:0003823 immune effector process#GO:0002252;immune system process#GO:0002376;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449;immune response#GO:0006955;adaptive immune response#GO:0002250;response to stimulus#GO:0050896 protein-containing complex#GO:0032991 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=30747|UniProtKB=P61201 P61201 COPS2 PTHR10678:SF3 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2 COP9 SIGNALOSOME COMPLEX SUBUNIT 2 structural molecule activity#GO:0005198;protein complex scaffold activity#GO:0140378 primary metabolic process#GO:0044238;protein modification process#GO:0036211;cellular process#GO:0009987;post-translational protein modification#GO:0043687;metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647;macromolecule metabolic process#GO:0043170;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;COP9 signalosome#GO:0008180;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 HUMAN|HGNC=7567|UniProtKB=P12882 P12882 MYH1 PTHR45615:SF2 MYOSIN HEAVY CHAIN, NON-MUSCLE MYOSIN-1 microfilament motor activity#GO:0000146;catalytic activity#GO:0003824;cytoskeletal protein binding#GO:0008092;macromolecular conformation isomerase activity#GO:0120543;cytoskeletal motor activity#GO:0003774;isomerase activity#GO:0016853;polypeptide conformation or assembly isomerase activity#GO:0120544;binding#GO:0005488;actin binding#GO:0003779;actin filament binding#GO:0051015;ATP-dependent activity#GO:0140657;protein binding#GO:0005515;protein-containing complex binding#GO:0044877 multicellular organismal process#GO:0032501;system process#GO:0003008;muscle system process#GO:0003012;muscle contraction#GO:0006936 supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;supramolecular complex#GO:0099080;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;actin cytoskeleton#GO:0015629;myosin complex#GO:0016459 actin or actin-binding cytoskeletal protein#PC00041 Wnt signaling pathway#P00057>NFAT Target Genes#G01559;Cytoskeletal regulation by Rho GTPase#P00016>Myosin#P00522;Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Myosin#P00867 HUMAN|HGNC=27007|UniProtKB=Q5T0D9 Q5T0D9 TPRG1L PTHR31108:SF7 TUMOR PROTEIN P63-REGULATED GENE 1-LIKE PROTEIN TUMOR PROTEIN P63-REGULATED GENE 1-LIKE PROTEIN presynapse#GO:0098793;secretory vesicle#GO:0099503;cytoplasm#GO:0005737;transport vesicle#GO:0030133;endomembrane system#GO:0012505;cell junction#GO:0030054;vesicle#GO:0031982;synaptic vesicle#GO:0008021;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410 HUMAN|HGNC=18435|UniProtKB=Q8WVB6 Q8WVB6 CHTF18 PTHR23389:SF33 CHROMOSOME TRANSMISSION FIDELITY FACTOR 18 CHROMOSOME TRANSMISSION FIDELITY PROTEIN 18 HOMOLOG catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543;helicase activity#GO:0004386;catalytic activity, acting on DNA#GO:0140097;DNA helicase activity#GO:0003678;isomerase activity#GO:0016853;binding#GO:0005488;nucleic acid binding#GO:0003676;ATP-dependent activity#GO:0140657;ATP-dependent activity, acting on DNA#GO:0008094;DNA binding#GO:0003677 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA metabolism protein#PC00009 HUMAN|HGNC=14335|UniProtKB=Q9HB21 Q9HB21 PLEKHA1 PTHR14336:SF4 TANDEM PH DOMAIN CONTAINING PROTEIN PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 1 small molecule binding#GO:0036094;anion binding#GO:0043168;binding#GO:0005488;phospholipid binding#GO:0005543;ion binding#GO:0043167;phosphatidylinositol bisphosphate binding#GO:1902936;lipid binding#GO:0008289 regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648;regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051896;negative regulation of intracellular signal transduction#GO:1902532;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of response to stimulus#GO:0048585 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886 HUMAN|HGNC=20892|UniProtKB=Q6JVE6 Q6JVE6 LCN10 PTHR11430:SF79 LIPOCALIN EPIDIDYMAL-SPECIFIC LIPOCALIN-10 transfer/carrier protein#PC00219 HUMAN|HGNC=28650|UniProtKB=Q8IYX0 Q8IYX0 ZNF679 PTHR24384:SF179 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED ZINC FINGER PROTEIN 679 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218 HUMAN|HGNC=11451|UniProtKB=O14730 O14730 RIOK3 PTHR45723:SF1 SERINE/THREONINE-PROTEIN KINASE RIO1 SERINE_THREONINE-PROTEIN KINASE RIO3 catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;ribosomal small subunit biogenesis#GO:0042274;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;maturation of SSU-rRNA#GO:0030490;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytosol#GO:0005829;ribonucleoprotein complex#GO:1990904;preribosome#GO:0030684 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=7556|UniProtKB=P12525 P12525 MYCLP1 PTHR45851:SF5 MYC PROTO-ONCOGENE PROTEIN L-MYC-RELATED sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 Wnt signaling pathway#P00057>Wnt Target Genes#G01558 HUMAN|HGNC=15608|UniProtKB=Q14978 Q14978 NOLC1 PTHR23216:SF2 NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1 NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226 HUMAN|HGNC=15621|UniProtKB=Q5M8T2 Q5M8T2 SLC35D3 PTHR11132:SF515 SOLUTE CARRIER FAMILY 35 SOLUTE CARRIER FAMILY 35 MEMBER D3 active transmembrane transporter activity#GO:0022804;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;antiporter activity#GO:0015297 localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;transport#GO:0006810;cellular process#GO:0009987 organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020 secondary carrier transporter#PC00258;transporter#PC00227 HUMAN|HGNC=28453|UniProtKB=Q8IVV7 Q8IVV7 GID4 PTHR15898:SF13 BIFUNCTIONAL APOPTOSIS REGULATOR GLUCOSE-INDUCED DEGRADATION PROTEIN 4 HOMOLOG ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824 primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511 HUMAN|HGNC=11153|UniProtKB=P14678 P14678 SNRPB PTHR10701:SF15 SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEINS B AND B' binding#GO:0005488;protein-containing complex binding#GO:0044877;ribonucleoprotein complex binding#GO:0043021 RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 organelle#GO:0043226;cellular anatomical structure#GO:0110165;U2-type prespliceosome#GO:0071004;intracellular membrane-bounded organelle#GO:0043231;U2-type spliceosomal complex#GO:0005684;U4 snRNP#GO:0005687;spliceosomal complex#GO:0005681;spliceosomal snRNP complex#GO:0097525;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;spliceosomal tri-snRNP complex#GO:0097526;U4/U6 x U5 tri-snRNP complex#GO:0046540;U1 snRNP#GO:0005685;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;small nuclear ribonucleoprotein complex#GO:0030532;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;Sm-like protein family complex#GO:0120114;U5 snRNP#GO:0005682;catalytic step 2 spliceosome#GO:0071013;U2 snRNP#GO:0005686 RNA splicing factor#PC00148 HUMAN|HGNC=3258|UniProtKB=P49770 P49770 EIF2B2 PTHR45859:SF1 TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA TRANSLATION INITIATION FACTOR EIF2B SUBUNIT BETA nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;translation initiation factor activity#GO:0003743;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085;translation factor activity#GO:0180051 metabolic process#GO:0008152;translation#GO:0006412;translational initiation#GO:0006413;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058 guanyl-nucleotide exchange factor complex#GO:0032045;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 translation initiation factor#PC00224 HUMAN|HGNC=19714|UniProtKB=Q8NEL9 Q8NEL9 DDHD1 PTHR23509:SF32 PA-PL1 PHOSPHOLIPASE FAMILY PHOSPHOLIPASE DDHD1 hydrolase activity, acting on ester bonds#GO:0016788;phospholipase activity#GO:0120569;lipase activity#GO:0016298;catalytic activity#GO:0003824;glycerophospholipase activity#GO:0004620;hydrolase activity#GO:0016787 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 phospholipase#PC00186;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=6050|UniProtKB=P29218 P29218 IMPA1 PTHR20854:SF26 INOSITOL MONOPHOSPHATASE INOSITOL MONOPHOSPHATASE 1 catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578 regulation of cellular process#GO:0050794;phospholipid biosynthetic process#GO:0008654;response to stimulus#GO:0050896;glycerolipid metabolic process#GO:0046486;small molecule metabolic process#GO:0044281;signaling#GO:0023052;phospholipid metabolic process#GO:0006644;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;organophosphate biosynthetic process#GO:0090407;cell communication#GO:0007154;lipid biosynthetic process#GO:0008610;glycerophospholipid metabolic process#GO:0006650;biological regulation#GO:0065007;biosynthetic process#GO:0009058;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;signal transduction#GO:0007165;alcohol metabolic process#GO:0006066;metabolic process#GO:0008152;phosphatidylinositol metabolic process#GO:0046488;lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 phosphatase#PC00181 HUMAN|HGNC=26428|UniProtKB=Q6NZ36 Q6NZ36 FAAP20 PTHR37862:SF1 FANCONI ANEMIA CORE COMPLEX-ASSOCIATED PROTEIN 20 FANCONI ANEMIA CORE COMPLEX-ASSOCIATED PROTEIN 20 protein binding#GO:0005515;polyubiquitin modification-dependent protein binding#GO:0031593;K63-linked polyubiquitin modification-dependent protein binding#GO:0070530;modification-dependent protein binding#GO:0140030;binding#GO:0005488 response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;DNA damage response#GO:0006974;cellular response to stress#GO:0033554;response to stress#GO:0006950 nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Fanconi anaemia nuclear complex#GO:0043240;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 HUMAN|HGNC=9813|UniProtKB=P54727 P54727 RAD23B PTHR10621:SF13 UV EXCISION REPAIR PROTEIN RAD23 LYSINE-SPECIFIC DEMETHYLASE RAD23B ubiquitin binding#GO:0043130;modification-dependent protein binding#GO:0140030;binding#GO:0005488;polyubiquitin modification-dependent protein binding#GO:0031593;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 DNA metabolism protein#PC00009;damaged DNA-binding protein#PC00086 HUMAN|HGNC=7165|UniProtKB=Q99542 Q99542 MMP19 PTHR10201:SF166 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE-19 metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096 metabolic process#GO:0008152;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;cellular process#GO:0009987;cellular component organization#GO:0016043;catabolic process#GO:0009056 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 metalloprotease#PC00153 Alzheimer disease-presenilin pathway#P00004>Matrix metalloprotease#P00130 HUMAN|HGNC=15579|UniProtKB=Q9BZR9 Q9BZR9 TRIM8 PTHR25465:SF19 B-BOX DOMAIN CONTAINING E3 UBIQUITIN-PROTEIN LIGASE TRIM8 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=26432|UniProtKB=Q8IVP9 Q8IVP9 ZNF547 PTHR24377:SF992 IP01015P-RELATED ZINC FINGER PROTEIN 17-RELATED sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=11313|UniProtKB=P10155 P10155 RO60 PTHR14202:SF0 60 KDA RIBONUCLEOPROTEIN SSA/RO RNA-BINDING PROTEIN RO60 nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 protein-containing complex#GO:0032991;ribonucleoprotein complex#GO:1990904 RNA metabolism protein#PC00031 HUMAN|HGNC=26147|UniProtKB=Q8NDL9 Q8NDL9 AGBL5 PTHR12756:SF12 CYTOSOLIC CARBOXYPEPTIDASE CYTOSOLIC CARBOXYPEPTIDASE-LIKE PROTEIN 5 catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;catalytic activity#GO:0003824;cytoskeletal protein binding#GO:0008092;metalloexopeptidase activity#GO:0008235;tubulin binding#GO:0015631;hydrolase activity#GO:0016787;metallocarboxypeptidase activity#GO:0004181;protein binding#GO:0005515;exopeptidase activity#GO:0008238;carboxypeptidase activity#GO:0004180;binding#GO:0005488;metallopeptidase activity#GO:0008237 cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;microtubule cytoskeleton#GO:0015630;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 metalloprotease#PC00153 HUMAN|HGNC=15720|UniProtKB=Q13033 Q13033 STRN3 PTHR15653:SF3 STRIATIN STRIATIN-3 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;negative regulation of cellular process#GO:0048523;regulation of intracellular signal transduction#GO:1902531;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cell communication#GO:0010646;negative regulation of signal transduction#GO:0009968;regulation of cellular process#GO:0050794;negative regulation of response to stimulus#GO:0048585;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519 cell junction#GO:0030054;dendrite#GO:0030425;dendritic tree#GO:0097447;synapse#GO:0045202;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;neuronal cell body#GO:0043025;cell projection#GO:0042995;somatodendritic compartment#GO:0036477;plasma membrane bounded cell projection#GO:0120025;postsynapse#GO:0098794;neuron projection#GO:0043005;cell body#GO:0044297 HUMAN|HGNC=2719|UniProtKB=P20711 P20711 DDC PTHR11999:SF167 GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE AROMATIC-L-AMINO-ACID DECARBOXYLASE lyase activity#GO:0016829;carbon-carbon lyase activity#GO:0016830;catalytic activity#GO:0003824;carboxy-lyase activity#GO:0016831 biosynthetic process#GO:0009058;biogenic amine metabolic process#GO:0006576;serotonin biosynthetic process#GO:0042427;phenol-containing compound metabolic process#GO:0018958;indole-containing compound metabolic process#GO:0042430;cellular process#GO:0009987;phenol-containing compound biosynthetic process#GO:0046189;amine metabolic process#GO:0009308;serotonin metabolic process#GO:0042428;catecholamine metabolic process#GO:0006584;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 decarboxylase#PC00089;lyase#PC00144 Nicotine pharmacodynamics pathway#P06587>DDC#P06608;Dopamine receptor mediated signaling pathway#P05912>DOPA decarb.#P05961;Adrenaline and noradrenaline biosynthesis#P00001>DOPA decarb.#P00066;5-Hydroxytryptamine biosynthesis#P04371>Aromatic L-amino acid decarboxylase#P04400 HUMAN|HGNC=14484|UniProtKB=Q13084 Q13084 MRPL28 PTHR13528:SF3 39S RIBOSOMAL PROTEIN L28, MITOCHONDRIAL LARGE RIBOSOMAL SUBUNIT PROTEIN BL28M structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 organelle lumen#GO:0043233;ribosome#GO:0005840;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;mitochondrial ribosome#GO:0005761;intracellular anatomical structure#GO:0005622;organellar ribosome#GO:0000313;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228;mitochondrial large ribosomal subunit#GO:0005762 translational protein#PC00263;ribosomal protein#PC00202 HUMAN|HGNC=25997|UniProtKB=Q53TQ3 Q53TQ3 INO80D PTHR16198:SF2 INO80 COMPLEX SUBUNIT D INO80 COMPLEX SUBUNIT D nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=2329|UniProtKB=Q92523 Q92523 CPT1B PTHR22589:SF69 CARNITINE O-ACYLTRANSFERASE CARNITINE O-PALMITOYLTRANSFERASE 1, MUSCLE ISOFORM acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;palmitoyltransferase activity#GO:0016409 establishment of localization#GO:0051234;carboxylic acid transport#GO:0046942;organic acid transport#GO:0015849;lipid metabolic process#GO:0006629;transport#GO:0006810;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;lipid transport#GO:0006869;cellular process#GO:0009987;macromolecule localization#GO:0033036;monocarboxylic acid transport#GO:0015718;fatty acid transport#GO:0015908;localization#GO:0051179;oxoacid metabolic process#GO:0043436;lipid localization#GO:0010876;small molecule metabolic process#GO:0044281;carnitine metabolic process#GO:0009437;carboxylic acid metabolic process#GO:0019752;modified amino acid metabolic process#GO:0006575;primary metabolic process#GO:0044238;monocarboxylic acid metabolic process#GO:0032787 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;acyltransferase#PC00042 HUMAN|HGNC=27267|UniProtKB=Q2TB10 Q2TB10 ZNF800 PTHR21020:SF2 ZINC FINGER PROTEIN 800 ZINC FINGER PROTEIN 800 HUMAN|HGNC=5043|UniProtKB=P31942 P31942 HNRNPH3 PTHR13976:SF36 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN H3 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of RNA splicing#GO:0043484;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148;RNA metabolism protein#PC00031;RNA processing factor#PC00147 HUMAN|HGNC=37280|UniProtKB=C9JH25 C9JH25 PRRT4 PTHR35578:SF6 PROLINE-RICH TRANSMEMBRANE PROTEIN 4-RELATED PROLINE-RICH TRANSMEMBRANE PROTEIN 4 HUMAN|HGNC=30296|UniProtKB=Q8IY67 Q8IY67 RAVER1 PTHR23189:SF46 RNA RECOGNITION MOTIF-CONTAINING RIBONUCLEOPROTEIN PTB-BINDING 1 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 RNA metabolism protein#PC00031 HUMAN|HGNC=24361|UniProtKB=A8K0Z3 A8K0Z3 WASHC1 PTHR23331:SF5 CXYORF1 WAS PROTEIN FAMILY HOMOLOG 2-RELATED actin filament-based process#GO:0030029;localization within membrane#GO:0051668;cellular localization#GO:0051641;secretion#GO:0046903;localization#GO:0051179;supramolecular fiber organization#GO:0097435;secretion by cell#GO:0032940;cellular component organization#GO:0016043;actin nucleation#GO:0045010;actin cytoskeleton organization#GO:0030036;endocytic recycling#GO:0032456;cytosolic transport#GO:0016482;export from cell#GO:0140352;intracellular transport#GO:0046907;transport#GO:0006810;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;exocytosis#GO:0006887;endosomal transport#GO:0016197;actin filament organization#GO:0007015;vesicle-mediated transport to the plasma membrane#GO:0098876;retrograde transport, endosome to Golgi#GO:0042147;organelle organization#GO:0006996;Arp2/3 complex-mediated actin nucleation#GO:0034314;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;cytoskeleton organization#GO:0007010 membrane-bounded organelle#GO:0043227;early endosome#GO:0005769;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768;recycling endosome#GO:0055037;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;vesicle#GO:0031982;intracellular vesicle#GO:0097708 membrane traffic protein#PC00150 HUMAN|HGNC=819|UniProtKB=P20648 P20648 ATP4A PTHR43294:SF10 SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA POTASSIUM-TRANSPORTING ATPASE ALPHA CHAIN 1 active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;P-type ion transporter activity#GO:0015662;monoatomic ion transmembrane transporter activity#GO:0015075;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;potassium ion transmembrane transporter activity#GO:0015079;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657 monoatomic ion transmembrane transport#GO:0034220;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;monoatomic ion homeostasis#GO:0050801;cellular homeostasis#GO:0019725;inorganic cation import across plasma membrane#GO:0098659;intracellular chemical homeostasis#GO:0055082;establishment of localization#GO:0051234;import into cell#GO:0098657;potassium ion import across plasma membrane#GO:1990573;transport#GO:0006810;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;inorganic ion import across plasma membrane#GO:0099587;homeostatic process#GO:0042592;export from cell#GO:0140352;metal ion transport#GO:0030001;import across plasma membrane#GO:0098739;sodium ion transport#GO:0006814;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;potassium ion homeostasis#GO:0055075;monoatomic cation transport#GO:0006812;localization#GO:0051179;inorganic ion homeostasis#GO:0098771 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227;primary active transporter#PC00068 HUMAN|HGNC=9799|UniProtKB=Q9UBK7 Q9UBK7 RABL2A PTHR24073:SF263 DRAB5-RELATED RAB-LIKE PROTEIN 2A-RELATED hydrolase activity, acting on acid anhydrides#GO:0016817;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787 intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907;protein transport#GO:0015031;intracellular protein localization#GO:0008104;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;macromolecule localization#GO:0033036 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 small GTPase#PC00208;G-protein#PC00020 HUMAN|HGNC=9967|UniProtKB=P07949 P07949 RET PTHR24416:SF485 TYROSINE-PROTEIN KINASE RECEPTOR PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET signaling receptor activity#GO:0038023;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714;transmembrane signaling receptor activity#GO:0004888 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cell surface receptor signaling pathway#GO:0007166;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154 membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;cell projection#GO:0042995;signaling receptor complex#GO:0043235;axon#GO:0030424 transmembrane signal receptor#PC00197 HUMAN|HGNC=3554|UniProtKB=Q92506 Q92506 HSD17B8 PTHR42760:SF141 SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER (3R)-3-HYDROXYACYL-COA DEHYDROGENASE oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;binding#GO:0005488;catalytic activity#GO:0003824;small molecule binding#GO:0036094 oxoacid metabolic process#GO:0043436;regulation of biological quality#GO:0065008;estrogen metabolic process#GO:0008210;carboxylic acid biosynthetic process#GO:0046394;regulation of hormone levels#GO:0010817;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;hormone biosynthetic process#GO:0042446;small molecule metabolic process#GO:0044281;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;monocarboxylic acid biosynthetic process#GO:0072330;steroid biosynthetic process#GO:0006694;cellular process#GO:0009987;biosynthetic process#GO:0009058;steroid metabolic process#GO:0008202;fatty acid biosynthetic process#GO:0006633;biological regulation#GO:0065007;hormone metabolic process#GO:0042445;lipid biosynthetic process#GO:0008610 oxidoreductase#PC00176 HUMAN|HGNC=14918|UniProtKB=Q9NYW0 Q9NYW0 TAS2R10 PTHR11394:SF63 TASTE RECEPTOR TYPE 2 TASTE RECEPTOR TYPE 2 MEMBER 10 signaling receptor activity#GO:0038023;taste receptor activity#GO:0008527;molecular transducer activity#GO:0060089;bitter taste receptor activity#GO:0033038;transmembrane signaling receptor activity#GO:0004888 detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;sensory perception of taste#GO:0050909;nervous system process#GO:0050877;detection of chemical stimulus involved in sensory perception of taste#GO:0050912;sensory perception#GO:0007600;detection of chemical stimulus involved in sensory perception of bitter taste#GO:0001580;system process#GO:0003008;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;sensory perception of bitter taste#GO:0050913;detection of chemical stimulus#GO:0009593;multicellular organismal process#GO:0032501;response to stimulus#GO:0050896;response to chemical#GO:0042221 membrane#GO:0016020;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=4375|UniProtKB=Q99445 Q99445 GML PTHR15049:SF2 GLYCOSYL-PHOSPHATIDYLINOSITOL-ANCHORED MOLECULE-LIKE PROTEIN-RELATED GLYCOSYL-PHOSPHATIDYLINOSITOL-ANCHORED MOLECULE-LIKE PROTEIN HUMAN|HGNC=17712|UniProtKB=O15304 O15304 SIVA1 PTHR14365:SF1 APOPTOSIS REGULATORY PROTEIN SIVA APOPTOSIS REGULATORY PROTEIN SIVA regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;immune system process#GO:0002376;regulation of signaling#GO:0023051;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;immune response-regulating signaling pathway#GO:0002764;apoptotic process#GO:0006915;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;extrinsic apoptotic signaling pathway#GO:0097191;signaling#GO:0023052;cell surface receptor signaling pathway#GO:0007166;immune response-activating signaling pathway#GO:0002757;lymphocyte homeostasis#GO:0002260;positive regulation of immune system process#GO:0002684;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;activation of immune response#GO:0002253;antigen receptor-mediated signaling pathway#GO:0050851;negative regulation of signal transduction#GO:0009968;homeostasis of number of cells#GO:0048872;regulation of immune response#GO:0050776;cell communication#GO:0007154;programmed cell death#GO:0012501;cellular response to stimulus#GO:0051716;cell death#GO:0008219;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;negative regulation of canonical NF-kappaB signal transduction#GO:0043124;immune response-activating cell surface receptor signaling pathway#GO:0002429;regulation of cell communication#GO:0010646;homeostatic process#GO:0042592;negative regulation of cellular process#GO:0048523;T cell receptor signaling pathway#GO:0050852;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;apoptotic signaling pathway#GO:0097190;multicellular organismal-level homeostasis#GO:0048871;regulation of canonical NF-kappaB signal transduction#GO:0043122;negative regulation of response to stimulus#GO:0048585;multicellular organismal process#GO:0032501;positive regulation of response to stimulus#GO:0048584;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768 HUMAN|HGNC=18024|UniProtKB=A1L4K1 A1L4K1 FSD2 PTHR24099:SF6 E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED FIBRONECTIN TYPE III AND SPRY DOMAIN-CONTAINING PROTEIN 2 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=37177|UniProtKB=A8MUK1 A8MUK1 USP17L5 PTHR24006:SF651 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE INACTIVE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 17-LIKE PROTEIN 4-RELATED catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;cysteine-type deubiquitinase activity#GO:0004843;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787 regulation of cellular process#GO:0050794;regulation of biological quality#GO:0065008;biological regulation#GO:0065007;regulation of programmed cell death#GO:0043067;regulation of apoptotic process#GO:0042981;regulation of biological process#GO:0050789;regulation of protein stability#GO:0031647 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 cysteine protease#PC00081;protease#PC00190 HUMAN|HGNC=29464|UniProtKB=Q5T751 Q5T751 LCE1C PTHR48615:SF8 LATE CORNIFIED ENVELOPE PROTEIN 1C LATE CORNIFIED ENVELOPE PROTEIN 1C HUMAN|HGNC=11191|UniProtKB=P35716 P35716 SOX11 PTHR10270:SF113 SOX TRANSCRIPTION FACTOR TRANSCRIPTION FACTOR SOX-11 transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulator activity#GO:0140110;DNA-binding transcription activator activity#GO:0001216;sequence-specific DNA binding#GO:0043565;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837 eye development#GO:0001654;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;negative regulation of DNA-templated transcription#GO:0045892;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;negative regulation of metabolic process#GO:0009892;cell differentiation#GO:0030154;central nervous system development#GO:0007417;regulation of transcription by RNA polymerase II#GO:0006357;sensory organ morphogenesis#GO:0090596;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;multicellular organism development#GO:0007275;animal organ development#GO:0048513;neuron differentiation#GO:0030182;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;positive regulation of transcription by RNA polymerase II#GO:0045944;head development#GO:0060322;nervous system development#GO:0007399;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;sensory system development#GO:0048880;system development#GO:0048731;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;camera-type eye development#GO:0043010;visual system development#GO:0150063;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;animal organ morphogenesis#GO:0009887;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;developmental process#GO:0032502;sensory organ development#GO:0007423;negative regulation of cellular process#GO:0048523;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;brain development#GO:0007420;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;multicellular organismal process#GO:0032501;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;camera-type eye morphogenesis#GO:0048593;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264;HMG box transcription factor#PC00024 HUMAN|HGNC=23333|UniProtKB=Q9NRG1 Q9NRG1 PRTFDC1 PTHR43340:SF5 HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE PHOSPHORIBOSYLTRANSFERASE DOMAIN-CONTAINING PROTEIN 1 ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;pentosyltransferase activity#GO:0016763;metal ion binding#GO:0046872;cation binding#GO:0043169;magnesium ion binding#GO:0000287;transferase activity#GO:0016740;catalytic activity#GO:0003824;glycosyltransferase activity#GO:0016757 metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing compound biosynthetic process#GO:0034654;purine nucleobase metabolic process#GO:0006144;carbohydrate derivative biosynthetic process#GO:1901137;purine nucleoside monophosphate metabolic process#GO:0009126;nucleobase-containing small molecule metabolic process#GO:0055086;ribose phosphate biosynthetic process#GO:0046390;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;purine-containing compound biosynthetic process#GO:0072522;nucleoside monophosphate biosynthetic process#GO:0009124;purine nucleotide biosynthetic process#GO:0006164;ribonucleotide metabolic process#GO:0009259;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide biosynthetic process#GO:0009165;phosphorus metabolic process#GO:0006793;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;small molecule metabolic process#GO:0044281;purine ribonucleoside monophosphate metabolic process#GO:0009167;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase metabolic process#GO:0009112;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;carbohydrate derivative metabolic process#GO:1901135;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;IMP biosynthetic process#GO:0006188;organophosphate biosynthetic process#GO:0090407;primary metabolic process#GO:0044238;IMP metabolic process#GO:0046040;nucleoside monophosphate metabolic process#GO:0009123;nucleoside phosphate metabolic process#GO:0006753 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;glycosyltransferase#PC00111 Adenine and hypoxanthine salvage pathway#P02723>Hypoxanthine phosphoribosyl transferase#P02804;Xanthine and guanine salvage pathway#P02788>Guanine phosphoribosyl transferase#P03245;Xanthine and guanine salvage pathway#P02788>Xanthine phosphoribosyl transferase#P03247 HUMAN|HGNC=15026|UniProtKB=Q8NHC7 Q8NHC7 OR14C36 PTHR26452:SF180 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 14C36 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606;nervous system process#GO:0050877;sensory perception#GO:0007600 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=8724|UniProtKB=P35558 P35558 PCK1 PTHR11561:SF18 PHOSPHOENOLPYRUVATE CARBOXYKINASE PHOSPHOENOLPYRUVATE CARBOXYKINASE, CYTOSOLIC [GTP] ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;transition metal ion binding#GO:0046914;lyase activity#GO:0016829;metal ion binding#GO:0046872;cation binding#GO:0043169;carboxy-lyase activity#GO:0016831;catalytic activity#GO:0003824;carbon-carbon lyase activity#GO:0016830 response to insulin#GO:0032868;cellular response to stimulus#GO:0051716;hexose metabolic process#GO:0019318;primary metabolic process#GO:0044238;response to steroid hormone#GO:0048545;anatomical structure development#GO:0048856;monosaccharide biosynthetic process#GO:0046364;biosynthetic process#GO:0009058;response to peptide hormone#GO:0043434;epithelium development#GO:0060429;response to glucose#GO:0009749;epithelial cell differentiation#GO:0030855;multicellular organismal process#GO:0032501;cellular response to insulin stimulus#GO:0032869;cellular homeostasis#GO:0019725;response to stimulus#GO:0050896;cellular response to hormone stimulus#GO:0032870;liver development#GO:0001889;cellular response to chemical stimulus#GO:0070887;response to monosaccharide#GO:0034284;animal gross anatomical part developmental process#GO:0160108;response to carbohydrate#GO:0009743;cellular response to oxygen-containing compound#GO:1901701;alcohol biosynthetic process#GO:0046165;cellular process#GO:0009987;carbohydrate biosynthetic process#GO:0016051;cellular response to lipid#GO:0071396;alcohol metabolic process#GO:0006066;glucose homeostasis#GO:0042593;multicellular organism development#GO:0007275;cellular response to steroid hormone stimulus#GO:0071383;hexose biosynthetic process#GO:0019319;response to starvation#GO:0042594;homeostatic process#GO:0042592;carbohydrate metabolic process#GO:0005975;cellular response to peptide hormone stimulus#GO:0071375;system development#GO:0048731;response to nitrogen compound#GO:1901698;response to nutrient levels#GO:0031667;tissue development#GO:0009888;cellular response to nitrogen compound#GO:1901699;developmental process#GO:0032502;small molecule biosynthetic process#GO:0044283;intracellular chemical homeostasis#GO:0055082;cellular developmental process#GO:0048869;carbohydrate homeostasis#GO:0033500;response to hexose#GO:0009746;response to endogenous stimulus#GO:0009719;carboxylic acid metabolic process#GO:0019752;cell differentiation#GO:0030154;small molecule metabolic process#GO:0044281;cellular response to endogenous stimulus#GO:0071495;response to oxygen-containing compound#GO:1901700;oxoacid metabolic process#GO:0043436;intracellular glucose homeostasis#GO:0001678;gluconeogenesis#GO:0006094;response to hormone#GO:0009725;response to stress#GO:0006950;response to chemical#GO:0042221;response to lipid#GO:0033993;chemical homeostasis#GO:0048878;metabolic process#GO:0008152;cellular response to glucose stimulus#GO:0071333;monosaccharide metabolic process#GO:0005996;animal organ development#GO:0048513;glucose metabolic process#GO:0006006 cytosol#GO:0005829;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 transferase#PC00220;kinase#PC00137;metabolite interconversion enzyme#PC00262 Pyruvate metabolism#P02772>Phosphoenolpyruvate Carboxykinase#P03135 HUMAN|HGNC=4982|UniProtKB=P08397 P08397 HMBS PTHR11557:SF0 PORPHOBILINOGEN DEAMINASE PORPHOBILINOGEN DEAMINASE transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765 pigment metabolic process#GO:0042440;heme biosynthetic process#GO:0006783;cellular process#GO:0009987;tetrapyrrole biosynthetic process#GO:0033014;biosynthetic process#GO:0009058;heme metabolic process#GO:0042168;metabolic process#GO:0008152;tetrapyrrole metabolic process#GO:0033013;pigment biosynthetic process#GO:0046148;porphyrin-containing compound metabolic process#GO:0006778;porphyrin-containing compound biosynthetic process#GO:0006779 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 metabolite interconversion enzyme#PC00262;deaminase#PC00088 Heme biosynthesis#P02746>Hydroxymethylbilane synthase#P02983 HUMAN|HGNC=491|UniProtKB=Q9Y5C1 Q9Y5C1 ANGPTL3 PTHR19143:SF222 FIBRINOGEN/TENASCIN/ANGIOPOEITIN ANGIOPOIETIN-RELATED PROTEIN 3 molecular function regulator activity#GO:0098772;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;enzyme inhibitor activity#GO:0004857 triglyceride homeostasis#GO:0070328;organophosphate catabolic process#GO:0046434;lipid homeostasis#GO:0055088;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;homeostatic process#GO:0042592;phospholipid metabolic process#GO:0006644;phospholipid catabolic process#GO:0009395;catabolic process#GO:0009056;lipid metabolic process#GO:0006629;chemical homeostasis#GO:0048878;metabolic process#GO:0008152;cholesterol homeostasis#GO:0042632;cellular process#GO:0009987;lipid catabolic process#GO:0016042;organophosphate metabolic process#GO:0019637 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 intercellular signal molecule#PC00207 HUMAN|HGNC=28295|UniProtKB=Q9BV29 Q9BV29 CCDC32 PTHR31800:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 32 COILED-COIL DOMAIN-CONTAINING PROTEIN 32 cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;plasma membrane bounded cell projection organization#GO:0120036;cilium organization#GO:0044782;cellular component organization or biogenesis#GO:0071840;cell projection organization#GO:0030030 HUMAN|HGNC=7471|UniProtKB=A0A3G1DJQ2 A0A3G1DJQ2 MT-RNR2 PTHR33895:SF5 HUMANIN-LIKE 4 HUMANIN-LIKE 4-RELATED signaling receptor regulator activity#GO:0030545;molecular function regulator activity#GO:0098772;molecular function inhibitor activity#GO:0140678;signaling receptor inhibitor activity#GO:0030547 negative regulation of programmed cell death#GO:0043069;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;biological regulation#GO:0065007;negative regulation of apoptotic process#GO:0043066;regulation of cellular process#GO:0050794;regulation of apoptotic process#GO:0042981;negative regulation of cellular process#GO:0048523 HUMAN|HGNC=4053|UniProtKB=P05161 P05161 ISG15 PTHR10666:SF267 UBIQUITIN UBIQUITIN-LIKE PROTEIN ISG15 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 catabolic process#GO:0009056;ISG15-protein conjugation#GO:0032020;response to external biotic stimulus#GO:0043207;primary metabolic process#GO:0044238;protein modification process#GO:0036211;modification-dependent protein catabolic process#GO:0019941;response to virus#GO:0009615;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;response to bacterium#GO:0009617;post-translational protein modification#GO:0043687;response to other organism#GO:0051707;immune response#GO:0006955;innate immune response#GO:0045087;macromolecule metabolic process#GO:0043170;defense response#GO:0006952;response to external stimulus#GO:0009605;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;defense response to virus#GO:0051607;protein modification by small protein conjugation#GO:0032446;immune system process#GO:0002376;protein modification by small protein conjugation or removal#GO:0070647;modification-dependent macromolecule catabolic process#GO:0043632;defense response to bacterium#GO:0042742;protein catabolic process#GO:0030163;defense response to other organism#GO:0098542;protein ubiquitination#GO:0016567;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;cellular process#GO:0009987;defense response to symbiont#GO:0140546;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152 membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cytosol#GO:0005829;cytosolic ribosome#GO:0022626;nucleus#GO:0005634;ribosome#GO:0005840 HUMAN|HGNC=7867|UniProtKB=P46087 P46087 NOP2 PTHR22807:SF30 NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING 28S RRNA (CYTOSINE(4447)-C(5))-METHYLTRANSFERASE methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;catalytic activity, acting on a rRNA#GO:0140102;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on RNA#GO:0140098;RNA methyltransferase activity#GO:0008173;rRNA methyltransferase activity#GO:0008649 rRNA base methylation#GO:0070475;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;maturation of LSU-rRNA#GO:0000470;gene expression#GO:0010467;metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;rRNA methylation#GO:0031167;rRNA modification#GO:0000154;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;nucleic acid biosynthetic process#GO:0141187;macromolecule methylation#GO:0043414;RNA modification#GO:0009451;ribosomal large subunit biogenesis#GO:0042273;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;RNA methylation#GO:0001510;RNA metabolic process#GO:0016070;methylation#GO:0032259;macromolecule modification#GO:0043412 membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular organelle#GO:0043229;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 RNA methyltransferase#PC00033;RNA metabolism protein#PC00031 HUMAN|HGNC=14294|UniProtKB=Q9BYB0 Q9BYB0 SHANK3 PTHR24135:SF4 SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN 3 protein binding#GO:0005515;signaling adaptor activity#GO:0035591;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;binding#GO:0005488;signaling receptor binding#GO:0005102;signaling receptor complex adaptor activity#GO:0030159 cell junction organization#GO:0034330;multicellular organismal process#GO:0032501;cellular process#GO:0009987;cellular component organization#GO:0016043;system process#GO:0003008;cellular component organization or biogenesis#GO:0071840;synapse organization#GO:0050808;nervous system process#GO:0050877;cognition#GO:0050890 plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;neuron to neuron synapse#GO:0098984;plasma membrane region#GO:0098590;postsynaptic specialization#GO:0099572;cell periphery#GO:0071944;neuron projection#GO:0043005;membrane#GO:0016020;cell junction#GO:0030054;synaptic membrane#GO:0097060;plasma membrane bounded cell projection#GO:0120025;neuron spine#GO:0044309;cell projection#GO:0042995;synapse#GO:0045202;cellular anatomical structure#GO:0110165;asymmetric synapse#GO:0032279;organelle#GO:0043226;dendritic spine#GO:0043197;postsynapse#GO:0098794;postsynaptic density#GO:0014069;dendritic tree#GO:0097447;postsynaptic membrane#GO:0045211;dendrite#GO:0030425 scaffold/adaptor protein#PC00226 Ionotropic glutamate receptor pathway#P00037>PSD95#P00999 HUMAN|HGNC=5275|UniProtKB=Q92993 Q92993 KAT5 PTHR10615:SF219 HISTONE ACETYLTRANSFERASE HISTONE ACETYLTRANSFERASE KAT5 protein-lysine-acetyltransferase activity#GO:0061733;acetyltransferase activity#GO:0016407;acyltransferase activity#GO:0016746;N-acetyltransferase activity#GO:0008080;protein N-acyltransferase activity#GO:0140186;histone acetyltransferase activity#GO:0004402;histone modifying activity#GO:0140993;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein N-acetyltransferase activity#GO:0034212;catalytic activity, acting on a protein#GO:0140096;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 cellular process#GO:0009987;response to stress#GO:0006950;nucleobase-containing compound metabolic process#GO:0006139;DNA recombination#GO:0006310;DNA damage response#GO:0006974;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;cellular response to stimulus#GO:0051716;double-strand break repair via homologous recombination#GO:0000724;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;recombinational repair#GO:0000725 protein acetyltransferase complex#GO:0031248;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;acetyltransferase complex#GO:1902493;chromosome#GO:0005694;cellular anatomical structure#GO:0110165;organelle#GO:0043226;transferase complex#GO:1990234;membraneless organelle#GO:0043228;intracellular protein-containing complex#GO:0140535;histone acetyltransferase complex#GO:0000123;chromatin#GO:0000785;H4 histone acetyltransferase complex#GO:1902562;protein-containing complex#GO:0032991;NuA4 histone acetyltransferase complex#GO:0035267;intracellular membraneless organelle#GO:0043232 histone modifying enzyme#PC00261;chromatin/chromatin-binding, or -regulatory protein#PC00077 Alzheimer disease-presenilin pathway#P00004>Tip60#P00137;Alzheimer disease-amyloid secretase pathway#P00003>Tip60#P00093 HUMAN|HGNC=18587|UniProtKB=O94901 O94901 SUN1 PTHR12911:SF23 SAD1/UNC-84-LIKE PROTEIN-RELATED SUN DOMAIN-CONTAINING PROTEIN 1 protein-membrane adaptor activity#GO:0043495;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;membrane#GO:0016020;membrane protein complex#GO:0098796;organelle envelope#GO:0031967 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=15811|UniProtKB=Q9NSI2 Q9NSI2 SLX9 PTHR31109:SF3 PROTEIN FAM207A RIBOSOME BIOGENESIS PROTEIN SLX9 HOMOLOG HUMAN|HGNC=17075|UniProtKB=Q9NYJ8 Q9NYJ8 TAB2 PTHR46253:SF2 TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN TAB TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 2 polyubiquitin modification-dependent protein binding#GO:0031593;binding#GO:0005488;K63-linked polyubiquitin modification-dependent protein binding#GO:0070530;modification-dependent protein binding#GO:0140030;protein binding#GO:0005515 multicellular organism development#GO:0007275;animal organ development#GO:0048513;positive regulation of canonical NF-kappaB signal transduction#GO:0043123;developmental process#GO:0032502;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;heart development#GO:0007507;positive regulation of response to stimulus#GO:0048584;multicellular organismal process#GO:0032501;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of canonical NF-kappaB signal transduction#GO:0043122;system development#GO:0048731;positive regulation of signaling#GO:0023056;anatomical structure development#GO:0048856;regulation of signaling#GO:0023051;animal gross anatomical part developmental process#GO:0160108;regulation of intracellular signal transduction#GO:1902531;regulation of cell communication#GO:0010646;circulatory system development#GO:0072359;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967 p38 MAPK pathway#P05918>TAB2#P06033 HUMAN|HGNC=16675|UniProtKB=O43423 O43423 ANP32CP PTHR11375:SF15 ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32 ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32 FAMILY MEMBER protein binding#GO:0005515;histone binding#GO:0042393;binding#GO:0005488 nuclear transport#GO:0051169;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;transport#GO:0006810;regulation of apoptotic process#GO:0042981;nucleocytoplasmic transport#GO:0006913;intracellular transport#GO:0046907;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;establishment of localization in cell#GO:0051649;regulation of biological process#GO:0050789;cellular process#GO:0009987;regulation of programmed cell death#GO:0043067 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;perinuclear region of cytoplasm#GO:0048471;cellular anatomical structure#GO:0110165;organelle#GO:0043226 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=9607|UniProtKB=P12272 P12272 PTHLH PTHR17223:SF0 PARATHYROID HORMONE-RELATED PARATHYROID HORMONE-RELATED PROTEIN signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;hormone receptor binding#GO:0051427;binding#GO:0005488;signaling receptor binding#GO:0005102;hormone activity#GO:0005179;molecular function activator activity#GO:0140677;protein binding#GO:0005515 regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;regulation of multicellular organismal development#GO:2000026;cell differentiation#GO:0030154;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;ossification#GO:0001503;signaling#GO:0023052;regulation of developmental process#GO:0050793;cell development#GO:0048468;G protein-coupled receptor signaling pathway#GO:0007186;animal gross anatomical part developmental process#GO:0160108;osteoblast differentiation#GO:0001649;skeletal system development#GO:0001501;cell communication#GO:0007154;anatomical structure development#GO:0048856;system development#GO:0048731;signal transduction#GO:0007165;cellular process#GO:0009987;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;regulation of multicellular organismal process#GO:0051239;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;developmental process#GO:0032502;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;regulation of cell differentiation#GO:0045595;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207;peptide hormone#PC00179 HUMAN|HGNC=11356|UniProtKB=Q9UJ98 Q9UJ98 STAG3 PTHR11199:SF8 STROMAL ANTIGEN COHESIN SUBUNIT SA-3 binding#GO:0005488;chromatin binding#GO:0003682 cellular component organization or biogenesis#GO:0071840;sister chromatid cohesion#GO:0007062;meiotic sister chromatid cohesion#GO:0051177;chromosome organization#GO:0051276;organelle organization#GO:0006996;cell cycle#GO:0007049;cellular component organization#GO:0016043;cell cycle process#GO:0022402;cellular process#GO:0009987 organelle#GO:0043226;cohesin complex#GO:0008278;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;nucleus#GO:0005634;chromatin#GO:0000785;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=34399|UniProtKB=Q6UW78 Q6UW78 UQCC3 PTHR36465:SF1 UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX ASSEMBLY FACTOR 3 UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX ASSEMBLY FACTOR 3 aerobic electron transport chain#GO:0019646;cellular respiration#GO:0045333;oxidative phosphorylation#GO:0006119;ATP synthesis coupled electron transport#GO:0042773;aerobic respiration#GO:0009060;cellular component organization#GO:0016043;mitochondrial electron transport, ubiquinol to cytochrome c#GO:0006122;protein-containing complex assembly#GO:0065003;metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091;cytochrome complex assembly#GO:0017004;energy derivation by oxidation of organic compounds#GO:0015980;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;electron transport chain#GO:0022900;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;respiratory electron transport chain#GO:0022904;mitochondrial ATP synthesis coupled electron transport#GO:0042775;cellular component assembly#GO:0022607;mitochondrion organization#GO:0007005;mitochondrial respiratory chain complex III assembly#GO:0034551;mitochondrial respiratory chain complex assembly#GO:0033108 membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020 chaperone#PC00072 HUMAN|HGNC=5318|UniProtKB=P24821 P24821 TNC PTHR46708:SF1 TENASCIN TENASCIN cellular process#GO:0009987;neuron projection development#GO:0031175;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regulation of cell adhesion#GO:0030155;neuron differentiation#GO:0030182;developmental process#GO:0032502;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;cell development#GO:0048468;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;cell projection organization#GO:0030030;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;neuron development#GO:0048666;system development#GO:0048731;anatomical structure development#GO:0048856 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012 extracellular matrix protein#PC00102 HUMAN|HGNC=24517|UniProtKB=Q9Y3T9 Q9Y3T9 NOC2L PTHR12687:SF10 NUCLEOLAR COMPLEX 2 AND RAD4-RELATED NUCLEOLAR COMPLEX PROTEIN 2 HOMOLOG cellular component organization or biogenesis#GO:0071840;ribonucleoprotein complex biogenesis#GO:0022613;ribosomal large subunit biogenesis#GO:0042273;cellular component biogenesis#GO:0044085;ribosome biogenesis#GO:0042254;cellular process#GO:0009987 membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;preribosome#GO:0030684;ribonucleoprotein complex#GO:1990904;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;preribosome, large subunit precursor#GO:0030687;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;90S preribosome#GO:0030686;organelle lumen#GO:0043233;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=11183|UniProtKB=P18583 P18583 SON PTHR46528:SF1 PROTEIN SON PROTEIN SON nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 regulation of biological process#GO:0050789;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA splicing#GO:0043484;regulation of macromolecule metabolic process#GO:0060255;regulation of mRNA processing#GO:0050684;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of mRNA metabolic process#GO:1903311;regulation of biosynthetic process#GO:0009889 RNA splicing factor#PC00148 HUMAN|HGNC=23086|UniProtKB=Q70EK9 Q70EK9 USP51 PTHR21646:SF38 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 51 catalytic activity#GO:0003824;cysteine-type deubiquitinase activity#GO:0004843;cysteine-type peptidase activity#GO:0008234;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787 regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological quality#GO:0065008;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of protein stability#GO:0031647;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 cysteine protease#PC00081 HUMAN|HGNC=30311|UniProtKB=Q8N3Y7 Q8N3Y7 SDR16C5 PTHR24322:SF728 PKSB EPIDERMAL RETINOL DEHYDROGENASE 2 alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;alcohol dehydrogenase (NAD+) activity#GO:0004022;all-trans-retinol dehydrogenase (NAD+) activity#GO:0004745 olefinic compound metabolic process#GO:0120254;retinol metabolic process#GO:0042572;terpenoid metabolic process#GO:0006721;isoprenoid metabolic process#GO:0006720;regulation of biological quality#GO:0065008;primary metabolic process#GO:0044238;regulation of hormone levels#GO:0010817;small molecule metabolic process#GO:0044281;alcohol metabolic process#GO:0006066;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;retinoid metabolic process#GO:0001523;diterpenoid metabolic process#GO:0016101;cellular process#GO:0009987;aldehyde metabolic process#GO:0006081;hormone metabolic process#GO:0042445;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;membraneless organelle#GO:0043228;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;lipid droplet#GO:0005811;intracellular membraneless organelle#GO:0043232;intracellular organelle#GO:0043229 dehydrogenase#PC00092 HUMAN|HGNC=24867|UniProtKB=Q9NZD2 Q9NZD2 GLTP PTHR10219:SF74 GLYCOLIPID TRANSFER PROTEIN-RELATED GLYCOLIPID TRANSFER PROTEIN phospholipid binding#GO:0005543;transporter activity#GO:0005215;small molecule binding#GO:0036094;anion binding#GO:0043168;binding#GO:0005488;ion binding#GO:0043167;molecular carrier activity#GO:0140104;lipid carrier activity#GO:0005319;phospholipid transfer activity#GO:0120014;lipid binding#GO:0008289;lipid transfer activity#GO:0120013 intermembrane lipid transfer#GO:0120009;establishment of localization#GO:0051234;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;transport#GO:0006810;lipid localization#GO:0010876;ceramide transport#GO:0035627;membrane organization#GO:0061024;lipid transport#GO:0006869;cellular process#GO:0009987;cellular component organization#GO:0016043;nitrogen compound transport#GO:0071705;macromolecule localization#GO:0033036 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;membrane#GO:0016020 transfer/carrier protein#PC00219 HUMAN|HGNC=11587|UniProtKB=Q12788 Q12788 TBL3 PTHR19854:SF15 TRANSDUCIN BETA-LIKE 3 TRANSDUCIN BETA-LIKE PROTEIN 3 nucleic acid binding#GO:0003676;snoRNA binding#GO:0030515;binding#GO:0005488;RNA binding#GO:0003723;U3 snoRNA binding#GO:0034511 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000479;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000480;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;maturation of SSU-rRNA#GO:0030490;nucleobase-containing compound metabolic process#GO:0006139;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;ribosomal small subunit biogenesis#GO:0042274;endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000472;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleolus#GO:0005730;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;preribosome#GO:0030684;intracellular organelle#GO:0043229;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;90S preribosome#GO:0030686;organelle lumen#GO:0043233;membraneless organelle#GO:0043228;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 scaffold/adaptor protein#PC00226 HUMAN|HGNC=560|UniProtKB=P56377 P56377 AP1S2 PTHR11753:SF45 ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY AP-1 COMPLEX SUBUNIT SIGMA-2 vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810;cellular process#GO:0009987 intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 vesicle coat protein#PC00235;membrane traffic protein#PC00150 HUMAN|HGNC=3825|UniProtKB=O14772 O14772 FPGT PTHR15045:SF1 FUCOSE-1-PHOSPHATE GUANYLYLTRANSFERASE FUCOSE-1-PHOSPHATE GUANYLYLTRANSFERASE catalytic activity#GO:0003824;transferase activity#GO:0016740;nucleotidyltransferase activity#GO:0016779;transferase activity, transferring phosphorus-containing groups#GO:0016772 organophosphate biosynthetic process#GO:0090407;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative biosynthetic process#GO:1901137;nucleoside phosphate biosynthetic process#GO:1901293;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;organophosphate metabolic process#GO:0019637;nucleotide-sugar metabolic process#GO:0009225;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058 transferase#PC00220 HUMAN|HGNC=28683|UniProtKB=Q8IYN2 Q8IYN2 TCEAL8 PTHR48555:SF1 TRANSCRIPTION ELONGATION FACTOR A PROTEIN-LIKE 8-RELATED TRANSCRIPTION ELONGATION FACTOR A PROTEIN-LIKE 8 HUMAN|HGNC=18407|UniProtKB=Q9BSE5 Q9BSE5 AGMAT PTHR11358:SF26 ARGINASE/AGMATINASE GUANIDINO ACID HYDROLASE, MITOCHONDRIAL hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;catalytic activity#GO:0003824 biogenic amine metabolic process#GO:0006576;biosynthetic process#GO:0009058;polyamine biosynthetic process#GO:0006596;polyamine metabolic process#GO:0006595;cellular process#GO:0009987;metabolic process#GO:0008152;amine metabolic process#GO:0009308 hydrolase#PC00121 HUMAN|HGNC=19383|UniProtKB=O15524 O15524 SOCS1 PTHR10155:SF4 PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT SUPPRESSOR OF CYTOKINE SIGNALING 1 protein binding#GO:0005515;signaling receptor binding#GO:0005102;cytokine receptor binding#GO:0005126;binding#GO:0005488 signaling#GO:0023052;regulation of cell communication#GO:0010646;regulation of receptor signaling pathway via STAT#GO:1904892;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;cellular response to stimulus#GO:0051716;negative regulation of biological process#GO:0048519;response to peptide#GO:1901652;negative regulation of cell communication#GO:0010648;cell communication#GO:0007154;regulation of signaling#GO:0023051;cytokine-mediated signaling pathway#GO:0019221;negative regulation of signaling#GO:0023057;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;response to cytokine#GO:0034097;response to chemical#GO:0042221;negative regulation of response to stimulus#GO:0048585;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of receptor signaling pathway via JAK-STAT#GO:0046425;regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166;negative regulation of cellular process#GO:0048523 kinase modulator#PC00140 JAK/STAT signaling pathway#P00038>SOCS#P01030 HUMAN|HGNC=26475|UniProtKB=Q1RMZ1 Q1RMZ1 SAMTOR PTHR21008:SF0 S-ADENOSYLMETHIONINE SENSOR UPSTREAM OF MTORC1-RELATED S-ADENOSYLMETHIONINE SENSOR UPSTREAM OF MTORC1 molecular sensor activity#GO:0140299;molecular function regulator activity#GO:0098772 response to nitrogen compound#GO:1901698;cellular response to chemical stimulus#GO:0070887;regulation of intracellular signal transduction#GO:1902531;response to oxygen-containing compound#GO:1901700;regulation of signaling#GO:0023051;cellular response to amino acid stimulus#GO:0071230;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;regulation of TORC1 signaling#GO:1903432;cellular response to nutrient levels#GO:0031669;regulation of response to stimulus#GO:0048583;response to chemical#GO:0042221;cellular response to nitrogen compound#GO:1901699;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;response to nutrient levels#GO:0031667;response to acid chemical#GO:0001101;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987;regulation of TOR signaling#GO:0032006 HUMAN|HGNC=12560|UniProtKB=Q5DID0 Q5DID0 UMODL1 PTHR14002:SF22 ENDOGLIN/TGF-BETA RECEPTOR TYPE III UROMODULIN-LIKE 1 cell surface#GO:0009986;cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 transmembrane signal receptor#PC00197 HUMAN|HGNC=895|UniProtKB=P37288 P37288 AVPR1A PTHR24241:SF17 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR VASOPRESSIN V1A RECEPTOR signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888 signaling#GO:0023052;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;cellular response to hormone stimulus#GO:0032870;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;positive regulation of multicellular organismal process#GO:0051240;cellular response to stimulus#GO:0051716;response to endogenous stimulus#GO:0009719;regulation of biological quality#GO:0065008;cell communication#GO:0007154;cellular response to chemical stimulus#GO:0070887;positive regulation of cytosolic calcium ion concentration#GO:0007204;G protein-coupled receptor signaling pathway#GO:0007186;circulatory system process#GO:0003013;biological regulation#GO:0065007;regulation of multicellular organismal process#GO:0051239;response to chemical#GO:0042221;blood circulation#GO:0008015;multicellular organismal process#GO:0032501;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;response to hormone#GO:0009725;system process#GO:0003008;regulation of anatomical structure size#GO:0090066;regulation of system process#GO:0044057 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=28487|UniProtKB=Q8NHS2 Q8NHS2 GOT1L1 PTHR11879:SF6 ASPARTATE AMINOTRANSFERASE ASPARTATE AMINOTRANSFERASE, CYTOPLASMIC 2 amino acid biosynthetic process#GO:0008652;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;small molecule biosynthetic process#GO:0044283;proteinogenic amino acid biosynthetic process#GO:0170038;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;carboxylic acid biosynthetic process#GO:0046394;aspartate family amino acid biosynthetic process#GO:0009067;cellular process#GO:0009987;proteinogenic amino acid metabolic process#GO:0170039;small molecule metabolic process#GO:0044281;amino acid metabolic process#GO:0006520;biosynthetic process#GO:0009058 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 transaminase#PC00216;transferase#PC00220;metabolite interconversion enzyme#PC00262 Asparagine and aspartate biosynthesis#P02730>Aspartate aminotransferase#P02854 HUMAN|HGNC=18873|UniProtKB=Q9BYX4 Q9BYX4 IFIH1 PTHR14074:SF14 HELICASE WITH DEATH DOMAIN-RELATED INTERFERON-INDUCED HELICASE C DOMAIN-CONTAINING PROTEIN 1 zinc ion binding#GO:0008270;single-stranded RNA binding#GO:0003727;double-stranded RNA binding#GO:0003725;transition metal ion binding#GO:0046914;ion binding#GO:0043167;nucleic acid binding#GO:0003676;binding#GO:0005488;small molecule binding#GO:0036094;cation binding#GO:0043169;RNA binding#GO:0003723;metal ion binding#GO:0046872 defense response to other organism#GO:0098542;regulation of response to external stimulus#GO:0032101;response to biotic stimulus#GO:0009607;positive regulation of immune system process#GO:0002684;response to stress#GO:0006950;defense response to symbiont#GO:0140546;signal transduction#GO:0007165;activation of immune response#GO:0002253;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;immune response-activating signaling pathway#GO:0002757;positive regulation of response to external stimulus#GO:0032103;response to stimulus#GO:0050896;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;defense response to virus#GO:0051607;regulation of biological process#GO:0050789;immune response-regulating signaling pathway#GO:0002764;cytoplasmic pattern recognition receptor signaling pathway#GO:0002753;immune system process#GO:0002376;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;response to other organism#GO:0051707;activation of innate immune response#GO:0002218;immune response#GO:0006955;positive regulation of innate immune response#GO:0045089;regulation of innate immune response#GO:0045088;innate immune response#GO:0045087;positive regulation of response to biotic stimulus#GO:0002833;response to external stimulus#GO:0009605;pattern recognition receptor signaling pathway#GO:0002221;defense response#GO:0006952;regulation of response to stress#GO:0080134;positive regulation of defense response#GO:0031349;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;intracellular receptor signaling pathway#GO:0030522;response to external biotic stimulus#GO:0043207;regulation of response to biotic stimulus#GO:0002831;innate immune response-activating signaling pathway#GO:0002758;antiviral innate immune response#GO:0140374;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;response to virus#GO:0009615;intracellular signal transduction#GO:0035556;regulation of immune response#GO:0050776;regulation of defense response#GO:0031347 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=4376|UniProtKB=P36959 P36959 GMPR PTHR43170:SF3 GMP REDUCTASE GMP REDUCTASE 1 oxidoreductase#PC00176;reductase#PC00198 HUMAN|HGNC=30368|UniProtKB=O95886 O95886 DLGAP3 PTHR12353:SF4 DISKS LARGE-ASSOCIATED PROTEIN DAP SAP90/PSD-95-ASSOCIATED PROTEIN DISKS LARGE-ASSOCIATED PROTEIN 3 regulation of cell communication#GO:0010646;biological regulation#GO:0065007;modulation of chemical synaptic transmission#GO:0050804;regulation of cellular process#GO:0050794;regulation of trans-synaptic signaling#GO:0099177;regulation of signaling#GO:0023051;regulation of biological process#GO:0050789 cell junction#GO:0030054;organelle#GO:0043226;postsynaptic specialization#GO:0099572;cellular anatomical structure#GO:0110165;glutamatergic synapse#GO:0098978;synapse#GO:0045202;postsynapse#GO:0098794 scaffold/adaptor protein#PC00226 HUMAN|HGNC=3169|UniProtKB=O95136 O95136 S1PR2 PTHR22750:SF17 G-PROTEIN COUPLED RECEPTOR SPHINGOSINE 1-PHOSPHATE RECEPTOR 2 signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;bioactive lipid receptor activity#GO:0045125 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021 HUMAN|HGNC=29417|UniProtKB=Q8TF44 Q8TF44 C2CD4C PTHR46291:SF5 C2 DOMAIN-CONTAINING PROTEIN C2 CALCIUM-DEPENDENT DOMAIN-CONTAINING PROTEIN 4C HUMAN|HGNC=542|UniProtKB=P09525 P09525 ANXA4 PTHR10502:SF28 ANNEXIN ANNEXIN A4 phosphatidylserine binding#GO:0001786;lipid binding#GO:0008289;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;phospholipid binding#GO:0005543;anion binding#GO:0043168 membrane#GO:0016020;vesicle membrane#GO:0012506;nucleus#GO:0005634;cell periphery#GO:0071944;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;plasma membrane#GO:0005886;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227 calcium-binding protein#PC00060 HUMAN|HGNC=13043|UniProtKB=P17030 P17030 ZNF25 PTHR24381:SF62 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 25 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|Ensembl=ENSG00000271254.7|UniProtKB=A0AAG2SUX2 A0AAG2SUX2 LOC124905564 PTHR14199:SF35 NEUROBLASTOMA BREAKPOINT FAMILY MEMBER 6-LIKE PROTEIN NBPF FAMILY MEMBER NBPF1-RELATED HUMAN|HGNC=2760|UniProtKB=Q9H4E7 Q9H4E7 DEF6 PTHR14383:SF2 SWAP-70 RECOMBINASE DIFFERENTIALLY EXPRESSED IN FDCP 6 HOMOLOG guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589 regulation of cellular process#GO:0050794;actin cytoskeleton organization#GO:0030036;response to stimulus#GO:0050896;actin filament polymerization#GO:0030041;signaling#GO:0023052;cellular component organization#GO:0016043;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;protein-containing complex assembly#GO:0065003;protein polymerization#GO:0051258;Rho protein signal transduction#GO:0007266;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;supramolecular fiber organization#GO:0097435;actin filament-based process#GO:0030029;cellular component assembly#GO:0022607;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;cytoskeleton organization#GO:0007010;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;actin polymerization or depolymerization#GO:0008154;signal transduction#GO:0007165;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;actin filament organization#GO:0007015 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;nucleus#GO:0005634;cell periphery#GO:0071944;membrane#GO:0016020;actin cytoskeleton#GO:0015629;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226 scaffold/adaptor protein#PC00226 HUMAN|HGNC=457|UniProtKB=P17707 P17707 AMD1 PTHR11570:SF0 S-ADENOSYLMETHIONINE DECARBOXYLASE S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME decarboxylase#PC00089;lyase#PC00144;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=32403|UniProtKB=Q8NAA5 Q8NAA5 LRRC75A PTHR14224:SF42 SIMILAR TO PREFERENTIALLY EXPRESSED ANTIGEN IN MELANOMA-LIKE 3 LEUCINE-RICH REPEAT-CONTAINING PROTEIN 75A ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;cullin-RING ubiquitin ligase complex#GO:0031461;Cul2-RING ubiquitin ligase complex#GO:0031462;transferase complex#GO:1990234;catalytic complex#GO:1902494;ubiquitin ligase complex#GO:0000151;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=13620|UniProtKB=Q8NFZ0 Q8NFZ0 FBH1 PTHR11070:SF30 UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER F-BOX DNA HELICASE 1 ATP-dependent activity, acting on DNA#GO:0008094;ATP-dependent activity#GO:0140657;helicase activity#GO:0004386;catalytic activity, acting on DNA#GO:0140097;3'-5' DNA helicase activity#GO:0043138;isomerase activity#GO:0016853;DNA helicase activity#GO:0003678;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;macromolecular conformation isomerase activity#GO:0120543 response to stimulus#GO:0050896;DNA replication#GO:0006260;cellular response to stimulus#GO:0051716;double-strand break repair via homologous recombination#GO:0000724;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;DNA-templated DNA replication#GO:0006261;cellular response to stress#GO:0033554;recombinational repair#GO:0000725;nucleobase-containing compound metabolic process#GO:0006139;replication fork processing#GO:0031297;cellular process#GO:0009987;response to stress#GO:0006950;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;DNA recombination#GO:0006310;DNA damage response#GO:0006974;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA metabolism protein#PC00009 HUMAN|HGNC=14846|UniProtKB=Q8NGP6 Q8NGP6 OR5M8 PTHR48018:SF83 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5M8 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cellular process#GO:0009987;signal transduction#GO:0007165;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;sensory perception of smell#GO:0007608;response to stimulus#GO:0050896;signaling#GO:0023052;G protein-coupled receptor signaling pathway#GO:0007186;nervous system process#GO:0050877;sensory perception#GO:0007600;cell communication#GO:0007154 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=16035|UniProtKB=Q7RTU9 Q7RTU9 STRC PTHR23412:SF14 STEREOCILIN RELATED STEREOCILIN-RELATED cell adhesion#GO:0007155;cell-matrix adhesion#GO:0007160;cellular process#GO:0009987;cell-substrate adhesion#GO:0031589 intracellular organelle#GO:0043229;cilium#GO:0005929;membrane-bounded organelle#GO:0043227;cluster of actin-based cell projections#GO:0098862;non-motile cilium#GO:0097730;intracellular anatomical structure#GO:0005622;actin-based cell projection#GO:0098858;actin cytoskeleton#GO:0015629;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;stereocilium#GO:0032420;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;neuron projection#GO:0043005;intracellular membraneless organelle#GO:0043232;cell surface#GO:0009986 cell adhesion molecule#PC00069 HUMAN|HGNC=19826|UniProtKB=Q86U38 Q86U38 NOP9 PTHR13102:SF0 NUCLEOLAR PROTEIN 9 NUCLEOLAR PROTEIN 9 binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 ribosomal small subunit biogenesis#GO:0042274;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000472;cellular component organization or biogenesis#GO:0071840;endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000480;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000479;cellular component biogenesis#GO:0044085;RNA processing#GO:0006396;maturation of SSU-rRNA#GO:0030490;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;RNA metabolic process#GO:0016070;cellular localization#GO:0051641;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;ribonucleoprotein complex biogenesis#GO:0022613;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;maturation of 5.8S rRNA#GO:0000460;establishment of organelle localization#GO:0051656;endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000447;transport#GO:0006810;rRNA metabolic process#GO:0016072;intracellular transport#GO:0046907;ribosomal subunit export from nucleus#GO:0000054;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;nucleocytoplasmic transport#GO:0006913;ribosomal small subunit export from nucleus#GO:0000056;ribosome localization#GO:0033750;organelle localization#GO:0051640;nuclear export#GO:0051168;rRNA processing#GO:0006364;nuclear transport#GO:0051169;localization#GO:0051179;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle lumen#GO:0043233;90S preribosome#GO:0030686;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;preribosome#GO:0030684;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;membraneless organelle#GO:0043228 RNA metabolism protein#PC00031 HUMAN|HGNC=4317|UniProtKB=P08151 P08151 GLI1 PTHR45718:SF2 TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS TRANSCRIPTION ACTIVATOR GLI1 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676 regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;signaling#GO:0023052;regulation of macromolecule metabolic process#GO:0060255;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;smoothened signaling pathway#GO:0007224;regulation of RNA metabolic process#GO:0051252;cell communication#GO:0007154;regulation of DNA-templated transcription#GO:0006355;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;cell surface receptor signaling pathway#GO:0007166;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 Hedgehog signaling pathway#P00025>Cubitus interruptus#P00690 HUMAN|HGNC=17160|UniProtKB=P53365 P53365 ARFIP2 PTHR12141:SF3 ARFAPTIN-RELATED ARFAPTIN-2 molecular sensor activity#GO:0140299;molecular function regulator activity#GO:0098772 cellular localization#GO:0051641;localization#GO:0051179;protein transport#GO:0015031;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of supramolecular fiber organization#GO:1902903;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;intracellular transport#GO:0046907;regulation of actin filament-based process#GO:0032970;regulation of actin nucleation#GO:0051125;transport#GO:0006810;intracellular protein transport#GO:0006886;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;regulation of actin filament organization#GO:0110053;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;regulation of actin cytoskeleton organization#GO:0032956;biological regulation#GO:0065007 Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;trans-Golgi network membrane#GO:0032588;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;trans-Golgi network#GO:0005802;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090 vesicle coat protein#PC00235 Huntington disease#P00029>Arfaptin-2#P00793 HUMAN|HGNC=37236|UniProtKB=A8MT33 A8MT33 SYCE1L PTHR21731:SF1 SYNAPTONEMAL COMPLEX CENTRAL ELEMENT PROTEIN 1-LIKE SYNAPTONEMAL COMPLEX CENTRAL ELEMENT PROTEIN 1-LIKE intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;organelle lumen#GO:0043233;chromosome#GO:0005694;membraneless organelle#GO:0043228;synaptonemal complex#GO:0000795;condensed nuclear chromosome#GO:0000794;condensed chromosome#GO:0000793;synaptonemal structure#GO:0099086;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974 HUMAN|HGNC=9566|UniProtKB=P48556 P48556 PSMD8 PTHR12387:SF1 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8 catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632 proteasome complex#GO:0000502;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;peptidase complex#GO:1905368;intracellular membrane-bounded organelle#GO:0043231;proteasome regulatory particle, lid subcomplex#GO:0008541;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;endopeptidase complex#GO:1905369;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535 protease#PC00190;protein modifying enzyme#PC00260 HUMAN|HGNC=4021|UniProtKB=Q06136 Q06136 KDSR PTHR43550:SF3 3-KETODIHYDROSPHINGOSINE REDUCTASE 3-KETODIHYDROSPHINGOSINE REDUCTASE oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;cellular process#GO:0009987;primary metabolic process#GO:0044238;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;sphingolipid metabolic process#GO:0006665;sphingolipid biosynthetic process#GO:0030148 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;membrane#GO:0016020;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 reductase#PC00198;oxidoreductase#PC00176 HUMAN|HGNC=5816|UniProtKB=P01624 P01624 IGKV3-15 PTHR23267:SF331 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN KAPPA VARIABLE 3-15-RELATED immune system process#GO:0002376;immune response#GO:0006955;response to stimulus#GO:0050896 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=14566|UniProtKB=Q9H1H9 Q9H1H9 KIF13A PTHR24115:SF458 KINESIN-RELATED KINESIN-LIKE PROTEIN KIF13A ATP-dependent activity#GO:0140657;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;protein binding#GO:0005515;hydrolase activity, acting on acid anhydrides#GO:0016817;cytoskeletal protein binding#GO:0008092;cytoskeletal motor activity#GO:0003774;polypeptide conformation or assembly isomerase activity#GO:0120544;microtubule binding#GO:0008017;microtubule motor activity#GO:0003777;ATP hydrolysis activity#GO:0016887;hydrolase activity#GO:0016787;tubulin binding#GO:0015631;macromolecular conformation isomerase activity#GO:0120543;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;isomerase activity#GO:0016853 microtubule-based movement#GO:0007018;macromolecule localization#GO:0033036;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;intracellular protein localization#GO:0008104;microtubule-based process#GO:0007017;protein transport#GO:0015031;intracellular transport#GO:0046907;transport#GO:0006810;intracellular protein transport#GO:0006886 organelle#GO:0043226;cellular anatomical structure#GO:0110165;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;intracellular organelle#GO:0043229;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;supramolecular polymer#GO:0099081;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cytoskeleton#GO:0005856 microtubule or microtubule-binding cytoskeletal protein#PC00157;microtubule binding motor protein#PC00156 HUMAN|HGNC=10013|UniProtKB=Q15835 Q15835 GRK1 PTHR24355:SF11 G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE RHODOPSIN KINASE GRK1 phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 non-receptor serine/threonine protein kinase#PC00167 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GPRK#P00701;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Rhodopsin kinase#P00750 HUMAN|HGNC=24272|UniProtKB=Q8NBJ9 Q8NBJ9 SIDT2 PTHR12185:SF16 SID1 TRANSMEMBRANE FAMILY MEMEBER SID1 TRANSMEMBRANE FAMILY MEMBER 2 nucleobase-containing compound transmembrane transporter activity#GO:0015932;RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;transmembrane transporter activity#GO:0022857;double-stranded RNA binding#GO:0003725;transporter activity#GO:0005215 macromolecule localization#GO:0033036;nitrogen compound transport#GO:0071705;establishment of RNA localization#GO:0051236;nucleobase-containing compound transport#GO:0015931;RNA localization#GO:0006403;RNA transport#GO:0050658;transport#GO:0006810;localization#GO:0051179;nucleic acid transport#GO:0050657;establishment of localization#GO:0051234 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;lytic vacuole#GO:0000323;lysosome#GO:0005764;cell periphery#GO:0071944;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;vacuole#GO:0005773;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=32418|UniProtKB=Q99666 Q99666 RGPD5 PTHR23138:SF175 RAN BINDING PROTEIN E3 SUMO-PROTEIN LIGASE RANBP2-RELATED catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-like protein transferase activity#GO:0019787;SUMO transferase activity#GO:0019789 protein localization to organelle#GO:0033365;nucleocytoplasmic transport#GO:0006913;nuclear transport#GO:0051169;protein transport#GO:0015031;protein import into nucleus#GO:0006606;nuclear export#GO:0051168;localization#GO:0051179;NLS-bearing protein import into nucleus#GO:0006607;cellular localization#GO:0051641;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;macromolecule localization#GO:0033036;import into nucleus#GO:0051170;protein localization to nucleus#GO:0034504;intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234 nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear pore#GO:0005643;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;nucleus#GO:0005634 scaffold/adaptor protein#PC00226 HUMAN|HGNC=2983|UniProtKB=P04053 P04053 DNTT PTHR11276:SF21 DNA POLYMERASE TYPE-X FAMILY MEMBER DNA NUCLEOTIDYLEXOTRANSFERASE transferase activity, transferring phosphorus-containing groups#GO:0016772;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on DNA#GO:0140097;DNA polymerase activity#GO:0034061;DNA-directed DNA polymerase activity#GO:0003887 macromolecule metabolic process#GO:0043170;double-strand break repair via nonhomologous end joining#GO:0006303;double-strand break repair#GO:0006302;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;DNA damage response#GO:0006974;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139;response to stress#GO:0006950;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-directed DNA polymerase#PC00018;DNA metabolism protein#PC00009 HUMAN|HGNC=10821|UniProtKB=Q9NP31 Q9NP31 SH2D2A PTHR14388:SF9 T CELL-SPECIFIC ADAPTER PROTEIN TSAD SH2 DOMAIN-CONTAINING PROTEIN 2A molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 multicellular organismal process#GO:0032501;lymphocyte activation#GO:0046649;T cell activation#GO:0042110;leukocyte activation#GO:0045321;immune system process#GO:0002376;cell activation#GO:0001775;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090 VEGF signaling pathway#P00056>VRAP#P01405;Angiogenesis#P00005>VRAP#P00196 HUMAN|HGNC=5394|UniProtKB=P05156 P05156 CFI PTHR24253:SF91 TRANSMEMBRANE PROTEASE SERINE COMPLEMENT FACTOR I serine-type peptidase activity#GO:0008236;catalytic activity#GO:0003824;serine hydrolase activity#GO:0017171;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;proteolysis#GO:0006508;metabolic process#GO:0008152;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 serine protease#PC00203;protease#PC00190;protein modifying enzyme#PC00260 HUMAN|HGNC=14632|UniProtKB=Q8N6G6 Q8N6G6 ADAMTSL1 PTHR13723:SF157 ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE ADAMTS-LIKE PROTEIN 1 catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233 proteolysis#GO:0006508;metabolic process#GO:0008152;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;protein metabolic process#GO:0019538;extracellular matrix organization#GO:0030198;cellular process#GO:0009987;cellular component organization#GO:0016043;primary metabolic process#GO:0044238 cellular anatomical structure#GO:0110165;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576 metalloprotease#PC00153 HUMAN|HGNC=20746|UniProtKB=P58004 P58004 SESN2 PTHR12474:SF2 P53 REGULATED PA26 NUCLEAR PROTEIN SESTRIN SESTRIN-2 catalytic activity#GO:0003824;amino acid binding#GO:0016597;oxidoreductase activity#GO:0016491;anion binding#GO:0043168;binding#GO:0005488;carboxylic acid binding#GO:0031406;small molecule binding#GO:0036094;ion binding#GO:0043167;organic acid binding#GO:0043177;oxidoreductase activity, acting on peroxide as acceptor#GO:0016684;cation binding#GO:0043169 negative regulation of TORC1 signaling#GO:1904262;regulation of macroautophagy#GO:0016241;positive regulation of autophagy#GO:0010508;response to stress#GO:0006950;positive regulation of biological process#GO:0048518;cellular response to oxygen-containing compound#GO:1901701;response to acid chemical#GO:0001101;regulation of TOR signaling#GO:0032006;cellular process#GO:0009987;cellular response to amino acid starvation#GO:0034198;response to chemical#GO:0042221;negative regulation of signal transduction#GO:0009968;negative regulation of signaling#GO:0023057;cellular response to chemical stimulus#GO:0070887;regulation of intracellular signal transduction#GO:1902531;response to oxygen-containing compound#GO:1901700;cellular response to stress#GO:0033554;regulation of signaling#GO:0023051;positive regulation of metabolic process#GO:0009893;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;regulation of autophagy#GO:0010506;regulation of biological process#GO:0050789;cellular response to amino acid stimulus#GO:0071230;response to stimulus#GO:0050896;positive regulation of macroautophagy#GO:0016239;cellular response to starvation#GO:0009267;negative regulation of cellular process#GO:0048523;cellular response to nutrient levels#GO:0031669;regulation of response to stimulus#GO:0048583;positive regulation of catabolic process#GO:0009896;regulation of TORC1 signaling#GO:1903432;regulation of catabolic process#GO:0009894;response to nutrient levels#GO:0031667;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;negative regulation of response to stimulus#GO:0048585;cellular response to nitrogen compound#GO:1901699;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;response to nitrogen compound#GO:1901698;response to starvation#GO:0042594;cellular response to stimulus#GO:0051716;negative regulation of TOR signaling#GO:0032007;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646 peroxidase#PC00180;oxidoreductase#PC00176 HUMAN|HGNC=1754|UniProtKB=P55291 P55291 CDH15 PTHR24027:SF300 CADHERIN-23 CADHERIN-15 protein binding#GO:0005515;beta-catenin binding#GO:0008013;binding#GO:0005488;cell adhesion molecule binding#GO:0050839 cell migration#GO:0016477;cell motility#GO:0048870;cell-cell adhesion#GO:0098609;cell adhesion#GO:0007155;cellular process#GO:0009987 extrinsic component of membrane#GO:0019898;extrinsic component of plasma membrane#GO:0019897;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 cell adhesion molecule#PC00069;cadherin#PC00057 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HUMAN|HGNC=16978|UniProtKB=Q14507 Q14507 EDDM3A PTHR16788:SF4 EPIDIDYMAL SECRETORY PROTEIN E3 ALPHA EPIDIDYMAL SECRETORY PROTEIN E3-ALPHA HUMAN|HGNC=13834|UniProtKB=Q9BZ76 Q9BZ76 CNTNAP3 PTHR15036:SF36 PIKACHURIN-LIKE PROTEIN CONTACTIN ASSOCIATED PROTEIN FAMILY MEMBER 3C-RELATED signal transduction#GO:0007165;cellular process#GO:0009987;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;nervous system development#GO:0007399;developmental process#GO:0032502;multicellular organism development#GO:0007275;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;animal gross anatomical part developmental process#GO:0160108;cell communication#GO:0007154;anatomical structure development#GO:0048856;system development#GO:0048731 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cell junction#GO:0030054;synapse#GO:0045202;cellular anatomical structure#GO:0110165 cell adhesion molecule#PC00069 HUMAN|HGNC=26358|UniProtKB=Q8IYE1 Q8IYE1 CCDC13 PTHR31935:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 13 COILED-COIL DOMAIN-CONTAINING PROTEIN 13 cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;plasma membrane bounded cell projection assembly#GO:0120031;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection organization#GO:0120036;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cell projection assembly#GO:0030031;cellular process#GO:0009987;non-motile cilium assembly#GO:1905515;microtubule cytoskeleton organization#GO:0000226;supramolecular fiber organization#GO:0097435;cilium organization#GO:0044782;organelle assembly#GO:0070925;cell projection organization#GO:0030030;cytoplasmic microtubule organization#GO:0031122;cellular component organization#GO:0016043;cilium assembly#GO:0060271 HUMAN|HGNC=4020|UniProtKB=Q9Y231 Q9Y231 FUT9 PTHR11929:SF10 ALPHA- 1,3 -FUCOSYLTRANSFERASE 4-GALACTOSYL-N-ACETYLGLUCOSAMINIDE 3-ALPHA-L-FUCOSYLTRANSFERASE 9 alpha-(1->3)-fucosyltransferase activity#GO:0046920;glycosyltransferase activity#GO:0016757;hexosyltransferase activity#GO:0016758;fucosyltransferase activity#GO:0008417;transferase activity#GO:0016740;catalytic activity#GO:0003824 glycosyltransferase#PC00111 HUMAN|HGNC=19740|UniProtKB=Q96RV3 Q96RV3 PCNX1 PTHR12372:SF2 PECANEX PECANEX-LIKE PROTEIN 1 HUMAN|HGNC=12679|UniProtKB=P11473 P11473 VDR PTHR24082:SF38 NUCLEAR HORMONE RECEPTOR VITAMIN D3 RECEPTOR steroid binding#GO:0005496;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;small molecule binding#GO:0036094;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;molecular transducer activity#GO:0060089;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;nuclear receptor activity#GO:0004879;sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;lipid binding#GO:0008289;transcription regulatory region nucleic acid binding#GO:0001067 positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;positive regulation of transcription by RNA polymerase II#GO:0045944;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of RNA biosynthetic process#GO:1902680;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C4 zinc finger nuclear receptor#PC00169 Vitamin D metabolism and pathway#P04396>VDR#P04606 HUMAN|HGNC=26184|UniProtKB=Q9H6E5 Q9H6E5 TUT1 PTHR12271:SF127 POLY A POLYMERASE CID PAP -RELATED SPECKLE TARGETED PIP5K1A-REGULATED POLY(A) POLYMERASE catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;nucleotidyltransferase activity#GO:0016779;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772 regulation of RNA stability#GO:0043487;regulation of RNA metabolic process#GO:0051252;positive regulation of mRNA catabolic process#GO:0061014;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;positive regulation of RNA metabolic process#GO:0051254;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;macromolecule metabolic process#GO:0043170;positive regulation of catabolic process#GO:0009896;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;nucleic acid catabolic process#GO:0141188;regulation of primary metabolic process#GO:0080090;nucleobase-containing compound catabolic process#GO:0034655;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;RNA catabolic process#GO:0006401;modification-dependent macromolecule catabolic process#GO:0043632;regulation of biological quality#GO:0065008;positive regulation of metabolic process#GO:0009893;RNA metabolic process#GO:0016070;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;negative regulation of gene expression#GO:0010629;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;regulation of mRNA stability#GO:0043488;metabolic process#GO:0008152;positive regulation of mRNA metabolic process#GO:1903313;mRNA destabilization#GO:0061157;macromolecule catabolic process#GO:0009057;regulation of mRNA metabolic process#GO:1903311;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;RNA destabilization#GO:0050779;positive regulation of macromolecule metabolic process#GO:0010604 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;nuclear speck#GO:0016607;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;membraneless organelle#GO:0043228;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232;nuclear body#GO:0016604 nucleotidyltransferase#PC00174 HUMAN|HGNC=16518|UniProtKB=Q5TA82 Q5TA82 LCE2D PTHR48615:SF7 LATE CORNIFIED ENVELOPE PROTEIN 1C LATE CORNIFIED ENVELOPE PROTEIN 2A-RELATED HUMAN|HGNC=4083|UniProtKB=P28472 P28472 GABRB3 PTHR18945:SF571 NEUROTRANSMITTER GATED ION CHANNEL GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-3 gated channel activity#GO:0022836;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic anion transmembrane transporter activity#GO:0008509;transporter activity#GO:0005215;chloride channel activity#GO:0005254;neurotransmitter receptor activity#GO:0030594;channel activity#GO:0015267;molecular transducer activity#GO:0060089;monoatomic anion channel activity#GO:0005253;ligand-gated monoatomic ion channel activity#GO:0015276;transmembrane transporter activity#GO:0022857;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;chloride transmembrane transporter activity#GO:0015108 chloride transport#GO:0006821;transport#GO:0006810;establishment of localization#GO:0051234;synaptic signaling#GO:0099536;cellular process#GO:0009987;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;trans-synaptic signaling#GO:0099537;transmembrane transport#GO:0055085;chloride transmembrane transport#GO:1902476;localization#GO:0051179;cell communication#GO:0007154;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698;chemical synaptic transmission#GO:0007268;monoatomic anion transport#GO:0006820;regulation of biological process#GO:0050789;anterograde trans-synaptic signaling#GO:0098916;signaling#GO:0023052 postsynapse#GO:0098794;membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane region#GO:0098590;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;synapse#GO:0045202;plasma membrane#GO:0005886;GABA-ergic synapse#GO:0098982;postsynaptic membrane#GO:0045211;synaptic membrane#GO:0097060;signaling receptor complex#GO:0043235;cell junction#GO:0030054 ligand-gated ion channel#PC00141 HUMAN|HGNC=17325|UniProtKB=Q9UF12 Q9UF12 PRODH2 PTHR13914:SF29 PROLINE OXIDASE HYDROXYPROLINE DEHYDROGENASE catalytic activity#GO:0003824;nucleotide binding#GO:0000166;heterocyclic compound binding#GO:1901363;oxidoreductase activity#GO:0016491;ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265;flavin adenine dinucleotide binding#GO:0050660;small molecule binding#GO:0036094;binding#GO:0005488;anion binding#GO:0043168 metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;proteinogenic amino acid metabolic process#GO:0170039;amino acid metabolic process#GO:0006520;small molecule catabolic process#GO:0044282;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739 oxidase#PC00175 Huntington disease#P00029>Proline oxidase#G01529 HUMAN|HGNC=24883|UniProtKB=Q9NSD7 Q9NSD7 RXFP3 PTHR24230:SF70 G-PROTEIN COUPLED RECEPTOR RELAXIN-3 RECEPTOR 1 signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;neuropeptide receptor activity#GO:0008188 biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;neuropeptide signaling pathway#GO:0007218;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021 HUMAN|HGNC=28326|UniProtKB=Q6UX07 Q6UX07 DHRS13 PTHR43157:SF44 PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 13 catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 glycosyltransferase#PC00111;transferase#PC00220 HUMAN|HGNC=17281|UniProtKB=Q9H3K2 Q9H3K2 GHITM PTHR23291:SF112 BAX INHIBITOR-RELATED GROWTH HORMONE-INDUCIBLE TRANSMEMBRANE PROTEIN monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation channel activity#GO:0005261;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;passive transmembrane transporter activity#GO:0022803;transporter activity#GO:0005215;calcium channel activity#GO:0005262;transmembrane transporter activity#GO:0022857 mitochondrial membrane organization#GO:0007006;cellular process#GO:0009987;release of sequestered calcium ion into cytosol#GO:0051209;inner mitochondrial membrane organization#GO:0007007;organelle organization#GO:0006996;mitochondrial calcium ion transmembrane transport#GO:0006851;mitochondrion organization#GO:0007005;membrane organization#GO:0061024;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;calcium ion transport#GO:0006816;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;calcium ion transmembrane import into cytosol#GO:0097553;calcium ion transmembrane transport#GO:0070588;cellular component organization#GO:0016043;metal ion transport#GO:0030001;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085 cytoplasm#GO:0005737;endomembrane system#GO:0012505;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrial membrane#GO:0031966;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;organelle membrane#GO:0031090;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;mitochondrion#GO:0005739;organelle envelope#GO:0031967;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229 transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=2468|UniProtKB=Q9UQE7 Q9UQE7 SMC3 PTHR43977:SF1 STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3 STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3 HUMAN|HGNC=8632|UniProtKB=P40424 P40424 PBX1 PTHR11850:SF89 HOMEOBOX PROTEIN TRANSCRIPTION FACTORS PRE-B-CELL LEUKEMIA TRANSCRIPTION FACTOR 1 sequence-specific DNA binding#GO:0043565;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;transcription regulatory region nucleic acid binding#GO:0001067;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription activator activity#GO:0001216;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976 regulation of nucleobase-containing compound metabolic process#GO:0019219;brain development#GO:0007420;positive regulation of DNA-templated transcription#GO:0045893;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of cellular process#GO:0048522;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;sensory organ development#GO:0007423;developmental process#GO:0032502;regulation of macromolecule metabolic process#GO:0060255;animal organ morphogenesis#GO:0009887;regulation of cellular process#GO:0050794;visual system development#GO:0150063;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biosynthetic process#GO:0009891;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;embryonic organ development#GO:0048568;positive regulation of macromolecule metabolic process#GO:0010604;nervous system development#GO:0007399;embryo development#GO:0009790;head development#GO:0060322;sensory system development#GO:0048880;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;multicellular organism development#GO:0007275;animal organ development#GO:0048513;positive regulation of transcription by RNA polymerase II#GO:0045944;neuron differentiation#GO:0030182;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;central nervous system development#GO:0007417;cell development#GO:0048468;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;eye development#GO:0001654;neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 Gonadotropin-releasing hormone receptor pathway#P06664>Pbx1#P06729 HUMAN|HGNC=7156|UniProtKB=P09238 P09238 MMP10 PTHR10201:SF270 MATRIX METALLOPROTEINASE STROMELYSIN-2 catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233 cellular component organization#GO:0016043;cellular process#GO:0009987;catabolic process#GO:0009056;extracellular structure organization#GO:0043062;metabolic process#GO:0008152;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;external encapsulating structure organization#GO:0045229 metalloprotease#PC00153 HUMAN|HGNC=31255|UniProtKB=Q8NG76 Q8NG76 OR2T33 PTHR26453:SF286 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2T33-RELATED molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 response to stimulus#GO:0050896;response to chemical#GO:0042221;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;detection of chemical stimulus#GO:0009593;system process#GO:0003008;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;sensory perception#GO:0007600;nervous system process#GO:0050877 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=24204|UniProtKB=Q5THR3 Q5THR3 EFCAB6 PTHR20875:SF2 EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 6-RELATED EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 6 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654 calmodulin-related#PC00061 HUMAN|HGNC=22407|UniProtKB=Q9NUM4 Q9NUM4 TMEM106B PTHR28556:SF1 TRANSMEMBRANE PROTEIN 106B TRANSMEMBRANE PROTEIN 106B organelle localization#GO:0051640;localization#GO:0051179;anatomical structure development#GO:0048856;vacuole organization#GO:0007033;system development#GO:0048731;dendrite morphogenesis#GO:0048813;intracellular transport#GO:0046907;vacuolar transport#GO:0007034;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;lytic vacuole organization#GO:0080171;transport#GO:0006810;cellular developmental process#GO:0048869;establishment of localization#GO:0051234;neurogenesis#GO:0022008;lysosome localization#GO:0032418;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;lysosomal transport#GO:0007041;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;dendrite development#GO:0016358;cellular localization#GO:0051641;neuron development#GO:0048666;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell morphogenesis#GO:0000902;cell development#GO:0048468;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cell projection morphogenesis#GO:0048858;neuron projection development#GO:0031175;organelle organization#GO:0006996;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;lysosome organization#GO:0007040;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;lytic vacuole membrane#GO:0098852;lysosome#GO:0005764;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;vacuolar membrane#GO:0005774;lytic vacuole#GO:0000323;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane#GO:0016020;lysosomal membrane#GO:0005765;cytoplasm#GO:0005737;vacuole#GO:0005773 HUMAN|HGNC=8003|UniProtKB=Q8IXM6 Q8IXM6 NRM PTHR31040:SF1 NURIM NURIM nucleus#GO:0005634;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;nuclear membrane#GO:0031965 HUMAN|HGNC=799|UniProtKB=P05023 P05023 ATP1A1 PTHR43294:SF9 SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA-1 primary active transmembrane transporter activity#GO:0015399;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;active transmembrane transporter activity#GO:0022804;monoatomic ion transmembrane transporter activity#GO:0015075;P-type ion transporter activity#GO:0015662;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic cation transmembrane transporter activity#GO:0008324;potassium ion transmembrane transporter activity#GO:0015079;ATPase-coupled transmembrane transporter activity#GO:0042626;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATP-dependent activity#GO:0140657 sodium ion transport#GO:0006814;intracellular monoatomic ion homeostasis#GO:0006873;metal ion transport#GO:0030001;export from cell#GO:0140352;homeostatic process#GO:0042592;inorganic ion import across plasma membrane#GO:0099587;import across plasma membrane#GO:0098739;inorganic ion homeostasis#GO:0098771;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;potassium ion homeostasis#GO:0055075;localization#GO:0051179;transmembrane transport#GO:0055085;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813;transport#GO:0006810;chemical homeostasis#GO:0048878;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;inorganic cation import across plasma membrane#GO:0098659;potassium ion import across plasma membrane#GO:1990573;import into cell#GO:0098657;establishment of localization#GO:0051234 ATPase dependent transmembrane transport complex#GO:0098533;sarcolemma#GO:0042383;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;cation-transporting ATPase complex#GO:0090533;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;membrane#GO:0016020 primary active transporter#PC00068;transporter#PC00227 HUMAN|HGNC=8024|UniProtKB=P34130 P34130 NTF4 PTHR11589:SF8 NERVE GROWTH FACTOR NGF -RELATED NEUROTROPHIN-4 growth factor activity#GO:0008083;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 response to growth factor#GO:0070848;regulation of cellular process#GO:0050794;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;system development#GO:0048731;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;negative regulation of apoptotic process#GO:0043066;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;cellular response to endogenous stimulus#GO:0071495;cell projection organization#GO:0030030;response to stimulus#GO:0050896;cell differentiation#GO:0030154;cell morphogenesis#GO:0000902;signaling#GO:0023052;cell development#GO:0048468;response to endogenous stimulus#GO:0009719;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cellular response to growth factor stimulus#GO:0071363;neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;regulation of signaling#GO:0023051;regulation of trans-synaptic signaling#GO:0099177;nervous system development#GO:0007399;neuron projection development#GO:0031175;regulation of neuron apoptotic process#GO:0043523;negative regulation of neuron apoptotic process#GO:0043524;signal transduction#GO:0007165;negative regulation of programmed cell death#GO:0043069;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cellular response to nerve growth factor stimulus#GO:1990090;cell projection morphogenesis#GO:0048858;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;regulation of apoptotic process#GO:0042981;cell surface receptor signaling pathway#GO:0007166 cell junction#GO:0030054;endomembrane system#GO:0012505;transport vesicle#GO:0030133;cytoplasm#GO:0005737;secretory vesicle#GO:0099503;presynapse#GO:0098793;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;exocytic vesicle#GO:0070382;extracellular region#GO:0005576;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;synaptic vesicle#GO:0008021;vesicle#GO:0031982 growth factor#PC00112;neurotrophic factor#PC00163 HUMAN|HGNC=24879|UniProtKB=Q6UY09 Q6UY09 CEACAM20 PTHR44427:SF7 CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 19 CELL ADHESION MOLECULE CEACAM20 protein binding#GO:0005515;binding#GO:0005488;kinase binding#GO:0019900;protein tyrosine kinase binding#GO:1990782;protein kinase binding#GO:0019901;enzyme binding#GO:0019899 cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;cell periphery#GO:0071944;membrane#GO:0016020 cell adhesion molecule#PC00069 HUMAN|HGNC=11990|UniProtKB=Q02880 Q02880 TOP2B PTHR10169:SF36 DNA TOPOISOMERASE/GYRASE DNA TOPOISOMERASE 2-BETA ATP-dependent activity#GO:0140657;ATP-dependent activity, acting on DNA#GO:0008094;macromolecular conformation isomerase activity#GO:0120543;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;isomerase activity#GO:0016853;catalytic activity, acting on DNA#GO:0140097 nucleobase-containing compound metabolic process#GO:0006139;organelle organization#GO:0006996;resolution of meiotic recombination intermediates#GO:0000712;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;meiotic nuclear division#GO:0140013;chromosome organization#GO:0051276;metabolic process#GO:0008152;meiotic cell cycle#GO:0051321;DNA metabolic process#GO:0006259;DNA recombination#GO:0006310;chromosome segregation#GO:0007059;reproductive process#GO:0022414;homologous recombination#GO:0035825;cell cycle#GO:0007049;nucleic acid metabolic process#GO:0090304;nuclear chromosome segregation#GO:0098813;primary metabolic process#GO:0044238;meiotic cell cycle process#GO:1903046;cellular component organization#GO:0016043;meiosis I#GO:0007127;sister chromatid segregation#GO:0000819;reciprocal homologous recombination#GO:0140527;cell cycle process#GO:0022402;organelle fission#GO:0048285;meiosis I cell cycle process#GO:0061982;nuclear division#GO:0000280;sexual reproduction#GO:0019953;reciprocal meiotic recombination#GO:0007131 chromosome#GO:0005694;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 DNA metabolism protein#PC00009 DNA replication#P00017>Top#P00530;DNA replication#P00017>DNA Topisomerase#P00536 HUMAN|HGNC=12612|UniProtKB=P54578 P54578 USP14 PTHR43982:SF1 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14 binding#GO:0005488;deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787;protein-containing complex binding#GO:0044877;catalytic activity#GO:0003824;cysteine-type deubiquitinase activity#GO:0004843;cysteine-type peptidase activity#GO:0008234;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783 regulation of protein catabolic process#GO:0042176;regulation of cellular response to stress#GO:0080135;negative regulation of catabolic process#GO:0009895;negative regulation of protein metabolic process#GO:0051248;negative regulation of metabolic process#GO:0009892;regulation of ERAD pathway#GO:1904292;negative regulation of proteasomal protein catabolic process#GO:1901799;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of response to endoplasmic reticulum stress#GO:1905897;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of catabolic process#GO:0009894;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;regulation of response to stress#GO:0080134;biological regulation#GO:0065007;negative regulation of response to stimulus#GO:0048585;negative regulation of protein catabolic process#GO:0042177;regulation of proteasomal protein catabolic process#GO:0061136;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;regulation of primary metabolic process#GO:0080090 protease#PC00190;cysteine protease#PC00081;protein modifying enzyme#PC00260 HUMAN|HGNC=23709|UniProtKB=Q8NAM6 Q8NAM6 ZSCAN4 PTHR23226:SF88 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 4 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=43627|UniProtKB=A0A1W2PR75 A0A1W2PR75 SSU72L6 PTHR20383:SF12 RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE SSU72 LIKE PROTEIN 6 catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787 metabolic process#GO:0008152;mRNA 3'-end processing#GO:0031124;nucleobase-containing compound biosynthetic process#GO:0034654;termination of RNA polymerase II transcription#GO:0006369;transcription by RNA polymerase II#GO:0006366;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;mRNA processing#GO:0006397;DNA-templated transcription termination#GO:0006353;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;DNA-templated transcription#GO:0006351 nucleus#GO:0005634;mRNA cleavage factor complex#GO:0005849;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;mRNA cleavage and polyadenylation specificity factor complex#GO:0005847;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 protein phosphatase#PC00195 HUMAN|HGNC=9806|UniProtKB=O60671 O60671 RAD1 PTHR10870:SF0 CELL CYCLE CHECKPOINT PROTEIN RAD1 CELL CYCLE CHECKPOINT PROTEIN RAD1 structural molecule activity#GO:0005198;protein complex scaffold activity#GO:0140378 negative regulation of cellular process#GO:0048523;DNA repair#GO:0006281;negative regulation of cell cycle process#GO:0010948;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;DNA integrity checkpoint signaling#GO:0031570;DNA damage checkpoint signaling#GO:0000077;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of cell cycle phase transition#GO:1901987;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;negative regulation of cell cycle#GO:0045786;response to stress#GO:0006950;cellular process#GO:0009987;signal transduction#GO:0007165;cell cycle checkpoint signaling#GO:0000075;regulation of cell cycle process#GO:0010564;cellular response to stress#GO:0033554;negative regulation of cell cycle phase transition#GO:1901988;negative regulation of biological process#GO:0048519;signal transduction in response to DNA damage#GO:0042770;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signaling#GO:0023052;regulation of cell cycle#GO:0051726 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;chromosome#GO:0005694;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;condensed chromosome#GO:0000793;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;condensed nuclear chromosome#GO:0000794;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232 DNA metabolism protein#PC00009;exodeoxyribonuclease#PC00098 HUMAN|HGNC=9143|UniProtKB=Q99453 Q99453 PHOX2B PTHR24329:SF301 HOMEOBOX PROTEIN ARISTALESS PAIRED MESODERM HOMEOBOX PROTEIN 2B sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677 regulation of biological process#GO:0050789;cell development#GO:0048468;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;regulation of RNA metabolic process#GO:0051252;neuron development#GO:0048666;system development#GO:0048731;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;nervous system development#GO:0007399;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;developmental process#GO:0032502;neuron differentiation#GO:0030182;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;multicellular organism development#GO:0007275 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=6255|UniProtKB=P48048 P48048 KCNJ1 PTHR11767:SF6 INWARD RECTIFIER POTASSIUM CHANNEL ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 1 transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261;ligand-gated monoatomic ion channel activity#GO:0015276;potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267 transport#GO:0006810;import into cell#GO:0098657;establishment of localization#GO:0051234;potassium ion import across plasma membrane#GO:1990573;inorganic cation import across plasma membrane#GO:0098659;cellular process#GO:0009987;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;import across plasma membrane#GO:0098739;inorganic ion import across plasma membrane#GO:0099587;metal ion transport#GO:0030001 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 ion channel#PC00133 HUMAN|HGNC=17416|UniProtKB=Q8WXG9 Q8WXG9 ADGRV1 PTHR46682:SF1 ADHESION G-PROTEIN COUPLED RECEPTOR V1 ADHESION G PROTEIN-COUPLED RECEPTOR V1 enzyme inhibitor activity#GO:0004857;cyclase regulator activity#GO:0010851;G protein-coupled receptor activity#GO:0004930;molecular function regulator activity#GO:0098772;signaling receptor activity#GO:0038023;cyclase inhibitor activity#GO:0010852;binding#GO:0005488;adenylate cyclase regulator activity#GO:0010854;adenylate cyclase inhibitor activity#GO:0010855;transmembrane signaling receptor activity#GO:0004888;protein binding#GO:0005515;molecular transducer activity#GO:0060089;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678 cellular response to chemical stimulus#GO:0070887;sensory perception of mechanical stimulus#GO:0050954;sensory perception#GO:0007600;response to metal ion#GO:0010038;nervous system process#GO:0050877;response to calcium ion#GO:0051592;system process#GO:0003008;sensory perception of light stimulus#GO:0050953;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;visual perception#GO:0007601;response to stimulus#GO:0050896;response to chemical#GO:0042221;sensory perception of sound#GO:0007605;multicellular organismal process#GO:0032501 stereocilium#GO:0032420;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;cluster of actin-based cell projections#GO:0098862;intracellular anatomical structure#GO:0005622;actin cytoskeleton#GO:0015629;neuron projection#GO:0043005;actin-based cell projection#GO:0098858;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025 G-protein coupled receptor#PC00021 HUMAN|HGNC=24877|UniProtKB=Q969M3 Q969M3 YIPF5 PTHR21236:SF6 GOLGI MEMBRANE PROTEIN YIP1 PROTEIN YIPF5 regulation of biological process#GO:0050789;Golgi organization#GO:0007030;regulation of vesicle-mediated transport#GO:0060627;cellular component organization#GO:0016043;vesicle fusion#GO:0006906;regulation of cellular process#GO:0050794;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle organization#GO:0006996;membrane fusion#GO:0061025;membrane organization#GO:0061024;endomembrane system organization#GO:0010256;biological regulation#GO:0065007;organelle membrane fusion#GO:0090174;organelle fusion#GO:0048284;vesicle-mediated transport#GO:0016192;Golgi vesicle transport#GO:0048193;transport#GO:0006810;intracellular transport#GO:0046907;regulation of localization#GO:0032879;regulation of transport#GO:0051049;vesicle organization#GO:0016050;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234 Golgi apparatus subcompartment#GO:0098791;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984 structural protein#PC00211 HUMAN|HGNC=30375|UniProtKB=Q9NR16 Q9NR16 CD163L1 PTHR19331:SF491 SCAVENGER RECEPTOR DOMAIN-CONTAINING SCAVENGER RECEPTOR CYSTEINE-RICH TYPE 1 PROTEIN M160 cargo receptor activity#GO:0038024 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 serine protease#PC00203;protease#PC00190 HUMAN|HGNC=16507|UniProtKB=Q8TBG9 Q8TBG9 SYNPR PTHR10306:SF16 SYNAPTOPHYSIN SYNAPTOPORIN organelle#GO:0043226;cellular anatomical structure#GO:0110165;synapse#GO:0045202;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;synaptic vesicle membrane#GO:0030672;synaptic vesicle#GO:0008021;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;transport vesicle#GO:0030133;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;transport vesicle membrane#GO:0030658;cytoplasm#GO:0005737;vesicle membrane#GO:0012506;membrane#GO:0016020;secretory vesicle#GO:0099503;presynapse#GO:0098793;cell junction#GO:0030054;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588 membrane traffic protein#PC00150;membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=609|UniProtKB=P02655 P02655 APOC2 PTHR16566:SF0 APOLIPOPROTEIN C-II APOLIPOPROTEIN C-II enzyme regulator activity#GO:0030234;protein binding#GO:0005515;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;binding#GO:0005488;enzyme activator activity#GO:0008047;enzyme binding#GO:0019899 macromolecule metabolic process#GO:0043170;plasma lipoprotein particle clearance#GO:0034381;protein metabolic process#GO:0019538;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;lipoprotein metabolic process#GO:0042157;catabolic process#GO:0009056;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;cellular process#GO:0009987 high-density lipoprotein particle#GO:0034364;plasma lipoprotein particle#GO:0034358;lipoprotein particle#GO:1990777;extracellular region#GO:0005576;extracellular protein-containing complex#GO:0140392;protein-lipid complex#GO:0032994;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;very-low-density lipoprotein particle#GO:0034361 transfer/carrier protein#PC00219;apolipoprotein#PC00052 HUMAN|HGNC=27984|UniProtKB=Q6ZMY9 Q6ZMY9 ZNF517 PTHR24379:SF20 KRAB AND ZINC FINGER DOMAIN-CONTAINING ZINC FINGER PROTEIN 517 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244;DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=25099|UniProtKB=Q6P2P2 Q6P2P2 PRMT9 PTHR11006:SF60 PROTEIN ARGININE N-METHYLTRANSFERASE PROTEIN ARGININE N-METHYLTRANSFERASE 9 catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741;protein methyltransferase activity#GO:0008276;histone modifying activity#GO:0140993;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;histone methyltransferase activity#GO:0042054;N-methyltransferase activity#GO:0008170 regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;chromatin remodeling#GO:0006338;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;chromatin organization#GO:0006325;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260 HUMAN|HGNC=20299|UniProtKB=Q9BWV3 Q9BWV3 CDADC1 PTHR11086:SF14 DEOXYCYTIDYLATE DEAMINASE-RELATED DCTP DEAMINASE catalytic activity#GO:0003824;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;deaminase activity#GO:0019239 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 hydrolase#PC00121;deaminase#PC00088 HUMAN|HGNC=6815|UniProtKB=P61326 P61326 MAGOH PTHR12638:SF2 PROTEIN MAGO NASHI HOMOLOG PROTEIN MAGO NASHI HOMOLOG RNA splicing#GO:0008380;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay#GO:0000184;macromolecule catabolic process#GO:0009057;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA catabolic process#GO:0006401;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of gene expression#GO:0010468;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;negative regulation of cellular process#GO:0048523;nuclear mRNA surveillance#GO:0071028;biosynthetic process#GO:0009058;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;nucleic acid catabolic process#GO:0141188;macromolecule biosynthetic process#GO:0009059;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;nucleobase-containing compound catabolic process#GO:0034655;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;exon-exon junction complex#GO:0035145;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=13070|UniProtKB=Q9NRM2 Q9NRM2 ZNF277 PTHR13267:SF3 ZINC FINGER PROTEIN 277 ZINC FINGER PROTEIN 277 zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=13006|UniProtKB=Q9UL59 Q9UL59 ZNF214 PTHR24377:SF660 IP01015P-RELATED ZINC FINGER PROTEIN 214 binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=19127|UniProtKB=O95057 O95057 DIRAS1 PTHR24070:SF213 RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY GTP-BINDING PROTEIN DI-RAS1 ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;signaling#GO:0023052;intracellular signaling cassette#GO:0141124;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 small GTPase#PC00208 HUMAN|HGNC=9067|UniProtKB=Q13393 Q13393 PLD1 PTHR18896:SF57 PHOSPHOLIPASE D PHOSPHOLIPASE D1 lipase activity#GO:0016298;hydrolase activity#GO:0016787;phospholipase activity#GO:0120569;hydrolase activity, acting on ester bonds#GO:0016788;glycerophospholipase activity#GO:0004620;catalytic activity#GO:0003824;phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578 organophosphate catabolic process#GO:0046434;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;phospholipid metabolic process#GO:0006644;catabolic process#GO:0009056;phospholipid catabolic process#GO:0009395;regulation of cellular process#GO:0050794;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;regulation of localization#GO:0032879;regulation of transport#GO:0051049;lipid catabolic process#GO:0016042;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;biological regulation#GO:0065007 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;cell periphery#GO:0071944;vesicle#GO:0031982;membrane#GO:0016020;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;organelle#GO:0043226 lipase#PC00143;phospholipase#PC00186 Angiogenesis#P00005>PLD#P00204;Ras Pathway#P04393>PLD#P04574 HUMAN|HGNC=27277|UniProtKB=A6NF34 A6NF34 ANTXRL PTHR16059:SF16 ANTHRAX TOXIN RECEPTOR ANTHRAX TOXIN RECEPTOR-LIKE signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;cell periphery#GO:0071944;membrane#GO:0016020 cell adhesion molecule#PC00069 HUMAN|HGNC=13433|UniProtKB=Q96MS0 Q96MS0 ROBO3 PTHR10075:SF133 BASIGIN RELATED ROUNDABOUT HOMOLOG 3 cell adhesion molecule#PC00069 Axon guidance mediated by Slit/Robo#P00008>Robo#P00348 HUMAN|Ensembl=ENSG00000288313.1|UniProtKB=A0AAG2TU05 A0AAG2TU05 PTHR23266:SF387 IMMUNOGLOBULIN HEAVY CHAIN IG-LIKE DOMAIN-CONTAINING PROTEIN-RELATED antigen binding#GO:0003823;binding#GO:0005488 immune effector process#GO:0002252;immune system process#GO:0002376;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;immune response#GO:0006955;adaptive immune response#GO:0002250;response to stimulus#GO:0050896 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=4115|UniProtKB=P54803 P54803 GALC PTHR15172:SF1 GALACTOCEREBROSIDASE GALACTOCEREBROSIDASE hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 catabolic process#GO:0009056;liposaccharide metabolic process#GO:1903509;glycolipid metabolic process#GO:0006664;carbohydrate derivative catabolic process#GO:1901136;sphingolipid catabolic process#GO:0030149;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;lipid catabolic process#GO:0016042;cellular process#GO:0009987;ceramide metabolic process#GO:0006672;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;lipid metabolic process#GO:0006629 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;lytic vacuole#GO:0000323;lysosome#GO:0005764;vacuole#GO:0005773;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 galactosidase#PC00104;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=32070|UniProtKB=Q96S90 Q96S90 LYSMD1 PTHR20932:SF2 LYSM AND PUTATIVE PEPTIDOGLYCAN-BINDING DOMAIN-CONTAINING PROTEIN AND PUTATIVE PEPTIDOGLYCAN-BINDING DOMAIN-CONTAINING PROTEIN 1-RELATED HUMAN|HGNC=9577|UniProtKB=P78330 P78330 PSPH PTHR43344:SF2 PHOSPHOSERINE PHOSPHATASE PHOSPHOSERINE PHOSPHATASE phosphoric ester hydrolase activity#GO:0042578;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;metal ion binding#GO:0046872;hydrolase activity#GO:0016787;magnesium ion binding#GO:0000287;cation binding#GO:0043169;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167 proteinogenic amino acid biosynthetic process#GO:0170038;small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;amino acid biosynthetic process#GO:0008652;biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;small molecule metabolic process#GO:0044281;proteinogenic amino acid metabolic process#GO:0170039;cellular process#GO:0009987;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;phosphatase#PC00181 Serine glycine biosynthesis#P02776>Phosphoserine phosphatase#P03159 HUMAN|HGNC=12856|UniProtKB=P25490 P25490 YY1 PTHR14003:SF10 TRANSCRIPTIONAL REPRESSOR PROTEIN YY TRANSCRIPTIONAL REPRESSOR PROTEIN YY1 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cell development#GO:0048468;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;cellular response to stress#GO:0033554;regulation of RNA metabolic process#GO:0051252;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;cellular process#GO:0009987;response to stress#GO:0006950;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;DNA damage response#GO:0006974;developmental process#GO:0032502;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;nucleus#GO:0005634;chromatin#GO:0000785;PcG protein complex#GO:0031519;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=33110|UniProtKB=Q6ZMW2 Q6ZMW2 ZNF782 PTHR24376:SF207 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 782 negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=23455|UniProtKB=Q5VYY2 Q5VYY2 LIPM PTHR11005:SF12 LYSOSOMAL ACID LIPASE-RELATED LIPASE MEMBER M hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;lipase activity#GO:0016298;catalytic activity#GO:0003824 cellular process#GO:0009987;lipid metabolic process#GO:0006629;primary metabolic process#GO:0044238;metabolic process#GO:0008152 hydrolase#PC00121;lipase#PC00143 HUMAN|HGNC=3676|UniProtKB=P09038 P09038 FGF2 PTHR11486:SF83 FIBROBLAST GROWTH FACTOR FIBROBLAST GROWTH FACTOR 2 growth factor activity#GO:0008083;growth factor receptor binding#GO:0070851;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;fibroblast growth factor receptor binding#GO:0005104;binding#GO:0005488;signaling receptor binding#GO:0005102;molecular function activator activity#GO:0140677;protein binding#GO:0005515 regulation of signaling#GO:0023051;animal gross anatomical part developmental process#GO:0160108;regulation of intracellular signal transduction#GO:1902531;cellular response to growth factor stimulus#GO:0071363;positive regulation of signaling#GO:0023056;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;positive regulation of cell population proliferation#GO:0008284;signaling#GO:0023052;response to stimulus#GO:0050896;cell differentiation#GO:0030154;cellular response to endogenous stimulus#GO:0071495;cell surface receptor signaling pathway#GO:0007166;regulation of MAPK cascade#GO:0043408;multicellular organism development#GO:0007275;cellular response to fibroblast growth factor stimulus#GO:0044344;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;nervous system development#GO:0007399;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;system development#GO:0048731;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;regulation of cell population proliferation#GO:0042127;regulation of cell motility#GO:2000145;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;response to growth factor#GO:0070848;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;developmental process#GO:0032502;regulation of cell migration#GO:0030334;response to fibroblast growth factor#GO:0071774;neurogenesis#GO:0022008;positive regulation of MAPK cascade#GO:0043410;cellular developmental process#GO:0048869;positive regulation of cellular process#GO:0048522;regulation of locomotion#GO:0040012;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;fibroblast growth factor receptor signaling pathway#GO:0008543;multicellular organismal process#GO:0032501;positive regulation of response to stimulus#GO:0048584 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;extracellular region#GO:0005576;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 growth factor#PC00112;intercellular signal molecule#PC00207 Angiogenesis#P00005>FGF#P00213;FGF signaling pathway#P00021>FGF#P00623 HUMAN|HGNC=33915|UniProtKB=A6NGW2 A6NGW2 STRCP1 PTHR23412:SF14 STEREOCILIN RELATED STEREOCILIN-RELATED cellular process#GO:0009987;cell-matrix adhesion#GO:0007160;cell adhesion#GO:0007155;cell-substrate adhesion#GO:0031589 intracellular membraneless organelle#GO:0043232;cell surface#GO:0009986;neuron projection#GO:0043005;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;stereocilium#GO:0032420;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;actin-based cell projection#GO:0098858;actin cytoskeleton#GO:0015629;non-motile cilium#GO:0097730;intracellular anatomical structure#GO:0005622;cluster of actin-based cell projections#GO:0098862;membrane-bounded organelle#GO:0043227;cilium#GO:0005929;intracellular organelle#GO:0043229 cell adhesion molecule#PC00069 HUMAN|HGNC=12472|UniProtKB=P49459 P49459 UBE2A PTHR24067:SF243 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2 A aminoacyltransferase activity#GO:0016755;ubiquitin conjugating enzyme activity#GO:0061631;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein conjugating enzyme activity#GO:0061650;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746 macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA damage response#GO:0006974;post-translational protein modification#GO:0043687;proteasomal protein catabolic process#GO:0010498;nucleobase-containing compound metabolic process#GO:0006139;protein ubiquitination#GO:0016567;response to stress#GO:0006950;cellular process#GO:0009987;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein modification by small protein conjugation or removal#GO:0070647;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;catabolic process#GO:0009056;response to stimulus#GO:0050896;protein modification process#GO:0036211;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941 chromatin#GO:0000785;chromosome#GO:0005694;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;ubiquitin ligase complex#GO:0000151 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 Ubiquitin proteasome pathway#P00060>E2#P01491 HUMAN|HGNC=42937|UniProtKB=P0DME0 P0DME0 SETSIP PTHR11875:SF105 TESTIS-SPECIFIC Y-ENCODED PROTEIN PROTEIN SETSIP protein binding#GO:0005515;binding#GO:0005488;histone binding#GO:0042393;chromatin binding#GO:0003682 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=14489|UniProtKB=Q9NZE8 Q9NZE8 MRPL35 PTHR15909:SF0 39S RIBOSOMAL PROTEIN L35, MITOCHONDRIAL LARGE RIBOSOMAL SUBUNIT PROTEIN BL35M membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739 ribosomal protein#PC00202 HUMAN|HGNC=18629|UniProtKB=Q8WWQ8 Q8WWQ8 STAB2 PTHR24038:SF0 STABILIN STABILIN-2 protein-containing complex binding#GO:0044877;cargo receptor activity#GO:0038024;low-density lipoprotein particle receptor activity#GO:0005041;low-density lipoprotein particle binding#GO:0030169;protein-lipid complex binding#GO:0071814;lipoprotein particle binding#GO:0071813;binding#GO:0005488 membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=9205|UniProtKB=Q15165 Q15165 PON2 PTHR11799:SF17 PARAOXONASE SERUM PARAOXONASE_ARYLESTERASE 2 hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;carboxylic ester hydrolase activity#GO:0052689 carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;carboxylic acid metabolic process#GO:0019752;small molecule catabolic process#GO:0044282;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;response to chemical#GO:0042221;response to stimulus#GO:0050896;response to toxic substance#GO:0009636;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HUMAN|HGNC=533|UniProtKB=P04083 P04083 ANXA1 PTHR10502:SF17 ANNEXIN ANNEXIN A1 lipid binding#GO:0008289;phosphatidylserine binding#GO:0001786;ion binding#GO:0043167;anion binding#GO:0043168;phospholipid binding#GO:0005543;binding#GO:0005488;small molecule binding#GO:0036094 cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;endocytosis#GO:0006897;cellular response to hormone stimulus#GO:0032870;signaling#GO:0023052;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;localization#GO:0051179;cell communication#GO:0007154;cellular response to chemical stimulus#GO:0070887;response to steroid hormone#GO:0048545;response to chemical#GO:0042221;cellular response to lipid#GO:0071396;response to lipid#GO:0033993;biological regulation#GO:0065007;response to hormone#GO:0009725;signal transduction#GO:0007165;cellular process#GO:0009987;import into cell#GO:0098657;cellular response to steroid hormone stimulus#GO:0071383;establishment of localization#GO:0051234;phagocytosis#GO:0006909;transport#GO:0006810 vesicle membrane#GO:0012506;membrane#GO:0016020;vesicle#GO:0031982;cell periphery#GO:0071944;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622 calcium-binding protein#PC00060 HUMAN|HGNC=13610|UniProtKB=Q8NHM5 Q8NHM5 KDM2B PTHR23123:SF10 PHD/F-BOX CONTAINING PROTEIN LYSINE-SPECIFIC DEMETHYLASE 2B histone modifying activity#GO:0140993;demethylase activity#GO:0032451;catalytic activity, acting on a protein#GO:0140096;protein demethylase activity#GO:0140457;histone demethylase activity#GO:0032452;catalytic activity#GO:0003824 cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;chromatin remodeling#GO:0006338;chromatin organization#GO:0006325 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 chromatin/chromatin-binding, or -regulatory protein#PC00077;histone modifying enzyme#PC00261 HUMAN|HGNC=23666|UniProtKB=Q5CZ79 Q5CZ79 ANKRD20A8P PTHR24147:SF1 ANKYRIN REPEAT DOMAIN 36-RELATED ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 20A1-RELATED HUMAN|HGNC=4807|UniProtKB=O96004 O96004 HAND1 PTHR23349:SF3 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST HEART- AND NEURAL CREST DERIVATIVES-EXPRESSED PROTEIN 1 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 heart development#GO:0007507;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;multicellular organism development#GO:0007275;animal organ development#GO:0048513;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;developmental process#GO:0032502;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;circulatory system development#GO:0072359;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;animal gross anatomical part developmental process#GO:0160108 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=2762|UniProtKB=P59666 P59666 DEFA3 PTHR11876:SF19 ALPHA-DEFENSIN 1 NEUTROPHIL DEFENSIN 1-RELATED humoral immune response#GO:0006959;antimicrobial humoral response#GO:0019730;response to external stimulus#GO:0009605;defense response#GO:0006952;innate immune response#GO:0045087;antibacterial humoral response#GO:0019731;defense response to symbiont#GO:0140546;immune response#GO:0006955;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;response to other organism#GO:0051707;defense response to other organism#GO:0098542;defense response to bacterium#GO:0042742;immune system process#GO:0002376;response to bacterium#GO:0009617;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;defense response to Gram-positive bacterium#GO:0050830;biological process involved in interspecies interaction between organisms#GO:0044419;defense response to Gram-negative bacterium#GO:0050829;response to external biotic stimulus#GO:0043207;response to stimulus#GO:0050896 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 antimicrobial response protein#PC00051 HUMAN|HGNC=26175|UniProtKB=Q6J4K2 Q6J4K2 SLC8B1 PTHR12266:SF39 NA+/CA2+ K+ INDEPENDENT EXCHANGER MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;antiporter activity#GO:0015297;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;secondary active transmembrane transporter activity#GO:0015291 inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;intracellular monoatomic ion homeostasis#GO:0006873;calcium ion transmembrane transport#GO:0070588;metal ion transport#GO:0030001;homeostatic process#GO:0042592;intracellular monoatomic cation homeostasis#GO:0030003;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;cellular homeostasis#GO:0019725;calcium ion transport#GO:0006816;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;establishment of localization#GO:0051234;calcium ion transmembrane import into cytosol#GO:0097553;cellular process#GO:0009987;release of sequestered calcium ion into cytosol#GO:0051209;mitochondrial calcium ion transmembrane transport#GO:0006851;monoatomic ion homeostasis#GO:0050801;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655 membrane#GO:0016020;cellular anatomical structure#GO:0110165 primary active transporter#PC00068;transporter#PC00227 HUMAN|HGNC=9682|UniProtKB=O14522 O14522 PTPRT PTHR19134:SF208 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE T hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;phosphoprotein phosphatase activity#GO:0004721;protein tyrosine phosphatase activity#GO:0004725;hydrolase activity#GO:0016787 neurogenesis#GO:0022008;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;neuron differentiation#GO:0030182;developmental process#GO:0032502;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;signal transduction#GO:0007165;cellular process#GO:0009987;neuron projection development#GO:0031175;system development#GO:0048731;neuron development#GO:0048666;cell communication#GO:0007154;anatomical structure development#GO:0048856;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;signaling#GO:0023052;cell development#GO:0048468;response to stimulus#GO:0050896;cell projection organization#GO:0030030;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular component organization#GO:0016043 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HUMAN|HGNC=201|UniProtKB=Q9P0K1 Q9P0K1 ADAM22 PTHR11905:SF14 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 22 endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 primary metabolic process#GO:0044238;proteolysis#GO:0006508;metabolic process#GO:0008152;cellular process#GO:0009987;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 postsynaptic density membrane#GO:0098839;postsynaptic density#GO:0014069;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;asymmetric synapse#GO:0032279;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;postsynapse#GO:0098794;cell junction#GO:0030054;synaptic membrane#GO:0097060;plasma membrane#GO:0005886;plasma membrane region#GO:0098590;postsynaptic specialization#GO:0099572;neuron to neuron synapse#GO:0098984;cell periphery#GO:0071944;membrane#GO:0016020 protease#PC00190;metalloprotease#PC00153 HUMAN|HGNC=14901|UniProtKB=Q969J5 Q969J5 IL22RA2 PTHR20859:SF51 INTERFERON/INTERLEUKIN RECEPTOR INTERLEUKIN-22 RECEPTOR SUBUNIT ALPHA-2 cytokine receptor activity#GO:0004896;transmembrane signaling receptor activity#GO:0004888;immune receptor activity#GO:0140375;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell communication#GO:0007154;response to peptide#GO:1901652;cytokine-mediated signaling pathway#GO:0019221;cell surface receptor signaling pathway#GO:0007166;regulation of cellular process#GO:0050794;response to cytokine#GO:0034097;response to stimulus#GO:0050896;response to chemical#GO:0042221;biological regulation#GO:0065007;signaling#GO:0023052;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;signal transduction#GO:0007165 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=43746|UniProtKB=D6RGX4 D6RGX4 FAM90A26 PTHR16035:SF14 PROTEIN FAM90A1 PROTEIN FAM90A10-RELATED HUMAN|HGNC=15848|UniProtKB=Q14141 Q14141 SEPTIN6 PTHR18884:SF55 SEPTIN SEPTIN-6 GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111 cytokinesis#GO:0000910;cytoskeleton-dependent cytokinesis#GO:0061640;localization#GO:0051179;intracellular protein localization#GO:0008104;cell cycle#GO:0007049;macromolecule localization#GO:0033036;cellular process#GO:0009987;cell division#GO:0051301;cell cycle process#GO:0022402 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;cell periphery#GO:0071944;cell cortex#GO:0005938;microtubule cytoskeleton#GO:0015630;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cell division site#GO:0032153;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 cytoskeletal protein#PC00085 HUMAN|HGNC=15993|UniProtKB=Q9H2A9 Q9H2A9 CHST8 PTHR12137:SF7 CARBOHYDRATE SULFOTRANSFERASE CARBOHYDRATE SULFOTRANSFERASE 8 transferase activity, transferring sulphur-containing groups#GO:0016782;sulfotransferase activity#GO:0008146;catalytic activity#GO:0003824;transferase activity#GO:0016740 metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;proteoglycan metabolic process#GO:0006029;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;proteoglycan biosynthetic process#GO:0030166;biosynthetic process#GO:0009058 transferase#PC00220 HUMAN|HGNC=4778|UniProtKB=Q16695 Q16695 H3-4 PTHR11426:SF276 HISTONE H3 HISTONE H3.1T nuclear division#GO:0000280;organelle localization#GO:0051640;organelle assembly#GO:0070925;kinetochore assembly#GO:0051382;organelle fission#GO:0048285;kinetochore organization#GO:0051383;localization#GO:0051179;membraneless organelle assembly#GO:0140694;nuclear chromosome segregation#GO:0098813;cellular component organization#GO:0016043;sister chromatid segregation#GO:0000819;cell cycle#GO:0007049;mitotic nuclear division#GO:0140014;cell cycle process#GO:0022402;protein-containing complex assembly#GO:0065003;mitotic metaphase chromosome alignment#GO:0007080;mitotic cell cycle#GO:0000278;metaphase chromosome alignment#GO:0051310;chromosome segregation#GO:0007059;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;chromosome organization#GO:0051276;mitotic cell cycle process#GO:1903047;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;mitotic sister chromatid segregation#GO:0000070;cellular process#GO:0009987;cellular component assembly#GO:0022607;chromosome localization#GO:0050000 chromatin/chromatin-binding, or -regulatory protein#PC00077 DNA replication#P00017>Histones#P00527 HUMAN|HGNC=14979|UniProtKB=Q15036 Q15036 SNX17 PTHR12431:SF16 SORTING NEXIN 17 AND 27 SORTING NEXIN-17 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 transport#GO:0006810;localization within membrane#GO:0051668;intracellular transport#GO:0046907;metabolic process#GO:0008152;vesicle-mediated transport to the plasma membrane#GO:0098876;endosomal transport#GO:0016197;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;endocytic recycling#GO:0032456 endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;early endosome#GO:0005769;intracellular vesicle#GO:0097708;vesicle#GO:0031982;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 scaffold/adaptor protein#PC00226 HUMAN|HGNC=11307|UniProtKB=P08240 P08240 SRPRA PTHR43134:SF1 SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA protein-containing complex binding#GO:0044877;ribonucleoprotein complex binding#GO:0043021;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;GTPase activity#GO:0003924;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462 establishment of protein localization#GO:0045184;localization#GO:0051179;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;protein targeting#GO:0006605;establishment of protein localization to endoplasmic reticulum#GO:0072599;protein targeting to ER#GO:0045047 endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226 protein-binding activity modulator#PC00095;G-protein#PC00020 HUMAN|HGNC=24885|UniProtKB=Q4ZG55 Q4ZG55 GREB1 PTHR15720:SF13 GREB1-RELATED PROTEIN GREB1 animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502;anatomical structure development#GO:0048856;tissue morphogenesis#GO:0048729;morphogenesis of an epithelium#GO:0002009;anatomical structure morphogenesis#GO:0009653;tissue development#GO:0009888;epithelium development#GO:0060429 HUMAN|HGNC=6352|UniProtKB=Q9NR64 Q9NR64 KLHL1 PTHR24412:SF75 KELCH PROTEIN KELCH-LIKE PROTEIN 1 enzyme-substrate adaptor activity#GO:0140767;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941 cytoplasm#GO:0005737;cullin-RING ubiquitin ligase complex#GO:0031461;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;ubiquitin ligase complex#GO:0000151;Cul3-RING ubiquitin ligase complex#GO:0031463;transferase complex#GO:1990234;catalytic complex#GO:1902494 scaffold/adaptor protein#PC00226 HUMAN|HGNC=19310|UniProtKB=Q86V86 Q86V86 PIM3 PTHR22984:SF26 SERINE/THREONINE-PROTEIN KINASE PIM SERINE_THREONINE-PROTEIN KINASE PIM-3 kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 negative regulation of cellular process#GO:0048523;regulation of apoptotic process#GO:0042981;negative regulation of apoptotic process#GO:0043066;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of cell cycle#GO:0051726;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;negative regulation of programmed cell death#GO:0043069;regulation of biological process#GO:0050789;regulation of mitotic cell cycle#GO:0007346 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=29514|UniProtKB=Q6ZMI3 Q6ZMI3 GLDN PTHR23192:SF85 OLFACTOMEDIN-RELATED GLIOMEDIN cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;cell surface#GO:0009986;extracellular region#GO:0005576 structural protein#PC00211 HUMAN|HGNC=11450|UniProtKB=Q96I99 Q96I99 SUCLG2 PTHR11815:SF11 SUCCINYL-COA SYNTHETASE BETA CHAIN SUCCINATE--COA LIGASE [GDP-FORMING] SUBUNIT BETA, MITOCHONDRIAL ligase activity, forming carbon-sulfur bonds#GO:0016877;catalytic activity#GO:0003824;ligase activity#GO:0016874 cellular respiration#GO:0045333;aerobic respiration#GO:0009060;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;purine-containing compound metabolic process#GO:0072521;energy derivation by oxidation of organic compounds#GO:0015980;acyl-CoA metabolic process#GO:0006637;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091;nucleobase-containing compound metabolic process#GO:0006139;organophosphate metabolic process#GO:0019637;tricarboxylic acid cycle#GO:0006099;sulfur compound metabolic process#GO:0006790;cellular process#GO:0009987 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739 ligase#PC00142 HUMAN|HGNC=35123|UniProtKB=A8MTJ6 A8MTJ6 FOXI3 PTHR11829:SF310 FORKHEAD BOX PROTEIN FORKHEAD BOX PROTEIN I3 double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;developmental process#GO:0032502;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 winged helix/forkhead transcription factor#PC00246;gene-specific transcriptional regulator#PC00264;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=20357|UniProtKB=Q9BUY7 Q9BUY7 EFCAB11 PTHR23050:SF354 CALCIUM BINDING PROTEIN EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 11 molecular function regulator activity#GO:0098772;calcium ion binding#GO:0005509;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;cation binding#GO:0043169;metal ion binding#GO:0046872;enzyme regulator activity#GO:0030234 microtubule-based process#GO:0007017;cytoskeleton organization#GO:0007010;microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 calcium-binding protein#PC00060;calmodulin-related#PC00061 HUMAN|HGNC=30022|UniProtKB=Q86YN6 Q86YN6 PPARGC1B PTHR15528:SF12 PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1 PGC-1 -RELATED PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA COACTIVATOR 1-BETA transcription coactivator activity#GO:0003713;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 homeostatic process#GO:0042592;positive regulation of RNA metabolic process#GO:0051254;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of DNA-templated transcription#GO:0006355;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;multicellular organismal-level homeostasis#GO:0048871;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of transcription by RNA polymerase II#GO:0045944 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HUMAN|HGNC=21557|UniProtKB=Q8IXY8 Q8IXY8 PPIL6 PTHR11071:SF585 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE INACTIVE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 6-RELATED chaperone#PC00072 HUMAN|HGNC=6347|UniProtKB=Q9Y5W3 Q9Y5W3 KLF2 PTHR23235:SF109 KRUEPPEL-LIKE TRANSCRIPTION FACTOR KRUEPPEL-LIKE FACTOR 2 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=1635|UniProtKB=P29016 P29016 CD1B PTHR16675:SF130 MHC CLASS I-RELATED T-CELL SURFACE GLYCOPROTEIN CD1B antigen binding#GO:0003823;binding#GO:0005488;lipid binding#GO:0008289 positive regulation of leukocyte mediated immunity#GO:0002705;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;positive regulation of immune system process#GO:0002684;immune response#GO:0006955;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;positive regulation of immune effector process#GO:0002699;regulation of lymphocyte mediated immunity#GO:0002706;immune system process#GO:0002376;regulation of immune response#GO:0050776;regulation of cell killing#GO:0031341;positive regulation of lymphocyte mediated immunity#GO:0002708;regulation of immune effector process#GO:0002697;antigen processing and presentation#GO:0019882;regulation of leukocyte mediated cytotoxicity#GO:0001910;regulation of leukocyte mediated immunity#GO:0002703;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;positive regulation of adaptive immune response#GO:0002821;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682 cell surface#GO:0009986;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;side of membrane#GO:0098552;external side of plasma membrane#GO:0009897;extracellular region#GO:0005576 defense/immunity protein#PC00090;major histocompatibility complex protein#PC00149 HUMAN|HGNC=14983|UniProtKB=Q96JP5 Q96JP5 ZFP91 PTHR46179:SF11 ZINC FINGER PROTEIN E3 UBIQUITIN-PROTEIN LIGASE ZFP91 transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 DNA-binding transcription factor#PC00218;zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=12947|UniProtKB=P17020 P17020 ZNF16 PTHR24377:SF879 IP01015P-RELATED ZINC FINGER PROTEIN 16 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=15595|UniProtKB=A0AV02 A0AV02 SLC12A8 PTHR11827:SF6 SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS SOLUTE CARRIER FAMILY 12 MEMBER 8 chloride transmembrane transporter activity#GO:0015108;secondary active transmembrane transporter activity#GO:0015291;monoatomic anion transmembrane transporter activity#GO:0008509;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;solute:monoatomic cation symporter activity#GO:0015294;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;symporter activity#GO:0015293;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324 potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;potassium ion transmembrane transport#GO:0071805;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;cellular process#GO:0009987;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;transport#GO:0006810 apical plasma membrane#GO:0016324;membrane#GO:0016020;apical part of cell#GO:0045177;cell periphery#GO:0071944;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 secondary carrier transporter#PC00258 HUMAN|HGNC=25305|UniProtKB=Q9H0G5 Q9H0G5 NSRP1 PTHR31938:SF4 NUCLEAR SPECKLE SPLICING REGULATORY PROTEIN 1 NUCLEAR SPECKLE SPLICING REGULATORY PROTEIN 1 HUMAN|HGNC=8673|UniProtKB=Q9UN72 Q9UN72 PCDHA7 PTHR24028:SF225 CADHERIN-87A PROTOCADHERIN ALPHA-7 cellular process#GO:0009987;cell adhesion#GO:0007155 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cadherin#PC00057;cell adhesion molecule#PC00069 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HUMAN|HGNC=24483|UniProtKB=Q9Y4R7 Q9Y4R7 TTLL3 PTHR45870:SF1 TUBULIN MONOGLYCYLASE TTLL3 TUBULIN MONOGLYCYLASE TTLL3 catalytic activity, acting on a protein#GO:0140096;ligase activity, forming carbon-nitrogen bonds#GO:0016879;catalytic activity#GO:0003824;ligase activity#GO:0016874 microtubule-based movement#GO:0007018;cell motility#GO:0048870;reproductive process#GO:0022414;developmental process involved in reproduction#GO:0003006;microtubule cytoskeleton organization#GO:0000226;axoneme assembly#GO:0035082;multicellular organismal reproductive process#GO:0048609;organelle assembly#GO:0070925;sexual reproduction#GO:0019953;microtubule bundle formation#GO:0001578;male gamete generation#GO:0048232;plasma membrane bounded cell projection organization#GO:0120036;flagellated sperm motility#GO:0030317;plasma membrane bounded cell projection assembly#GO:0120031;developmental process#GO:0032502;spermatogenesis#GO:0007283;cell projection organization#GO:0030030;gamete generation#GO:0007276;cellular component organization#GO:0016043;cilium assembly#GO:0060271;sperm motility#GO:0097722;cilium-dependent cell motility#GO:0060285;cilium organization#GO:0044782;cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cilium movement involved in cell motility#GO:0060294;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017 microtubule cytoskeleton#GO:0015630;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;sperm flagellum#GO:0036126;ciliary plasm#GO:0097014;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;motile cilium#GO:0031514;intracellular organelle#GO:0043229;cilium#GO:0005929;9+2 motile cilium#GO:0097729;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;axoneme#GO:0005930 HUMAN|Gene=NPEPPSL1|UniProtKB=A6NEC2 A6NEC2 NPEPPSL1 PTHR11533:SF174 PROTEASE M1 ZINC METALLOPROTEASE PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED metalloaminopeptidase activity#GO:0070006;hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;metallopeptidase activity#GO:0008237;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;metalloexopeptidase activity#GO:0008235;aminopeptidase activity#GO:0004177;catalytic activity#GO:0003824 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518;metabolic process#GO:0008152;proteolysis#GO:0006508;catabolic process#GO:0009056;primary metabolic process#GO:0044238;cellular process#GO:0009987;peptide catabolic process#GO:0043171 protease#PC00190;metalloprotease#PC00153 HUMAN|HGNC=8117|UniProtKB=Q9UKZ4 Q9UKZ4 TENM1 PTHR11219:SF7 TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE TENEURIN-1 signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515 cell junction organization#GO:0034330;synapse organization#GO:0050808;anatomical structure development#GO:0048856;system development#GO:0048731;axon guidance#GO:0007411;axon development#GO:0061564;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;neuron projection guidance#GO:0097485;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell development#GO:0048468;animal gross anatomical part developmental process#GO:0160108;cell adhesion#GO:0007155;generation of neurons#GO:0048699;axonogenesis#GO:0007409;neuron development#GO:0048666;synaptic membrane adhesion#GO:0099560;cell-cell adhesion#GO:0098609;neuron projection development#GO:0031175;cellular process#GO:0009987;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cell projection morphogenesis#GO:0048858 cell junction#GO:0030054;cellular anatomical structure#GO:0110165;glutamatergic synapse#GO:0098978;synapse#GO:0045202;plasma membrane#GO:0005886;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944 HUMAN|HGNC=13529|UniProtKB=Q9Y2B0 Q9Y2B0 CNPY2 PTHR13341:SF6 MIR-INTERACTING SAPOSIN-LIKE PROTEIN PROTEIN CANOPY HOMOLOG 2 enzyme inhibitor activity#GO:0004857;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;molecular function inhibitor activity#GO:0140678 regulation of biological process#GO:0050789;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 HUMAN|HGNC=4766|UniProtKB=P68431 P68431 H3C1 PTHR11426:SF242 HISTONE H3 HISTONE H3.1 cellular component organization or biogenesis#GO:0071840;chromosome organization#GO:0051276;protein-containing complex organization#GO:0043933;mitotic cell cycle process#GO:1903047;metaphase chromosome alignment#GO:0051310;chromosome segregation#GO:0007059;cellular component assembly#GO:0022607;chromosome localization#GO:0050000;mitotic sister chromatid segregation#GO:0000070;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;organelle fission#GO:0048285;kinetochore organization#GO:0051383;localization#GO:0051179;organelle localization#GO:0051640;nuclear division#GO:0000280;organelle assembly#GO:0070925;kinetochore assembly#GO:0051382;mitotic cell cycle#GO:0000278;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;nuclear chromosome segregation#GO:0098813;sister chromatid segregation#GO:0000819;cell cycle#GO:0007049;cell cycle process#GO:0022402;mitotic nuclear division#GO:0140014;protein-containing complex assembly#GO:0065003;mitotic metaphase chromosome alignment#GO:0007080 chromatin/chromatin-binding, or -regulatory protein#PC00077 DNA replication#P00017>Histones#P00527 HUMAN|HGNC=11712|UniProtKB=Q9BXT4 Q9BXT4 TDRD1 PTHR22948:SF4 TUDOR DOMAIN CONTAINING PROTEIN TUDOR DOMAIN-CONTAINING PROTEIN 1 multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;anterior/posterior axis specification#GO:0009948;metabolic process#GO:0008152;anterior/posterior pattern specification#GO:0009952;nucleobase-containing compound biosynthetic process#GO:0034654;RNA processing#GO:0006396;embryo development#GO:0009790;oogenesis#GO:0048477;cellular component assembly#GO:0022607;gene expression#GO:0010467;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;embryonic pattern specification#GO:0009880;negative regulation of macromolecule biosynthetic process#GO:0010558;organelle organization#GO:0006996;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;negative regulation of metabolic process#GO:0009892;cellular process involved in reproduction in multicellular organism#GO:0022412;cell development#GO:0048468;cell differentiation#GO:0030154;gamete generation#GO:0007276;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;regulation of gene expression#GO:0010468;regulatory ncRNA processing#GO:0070918;cell maturation#GO:0048469;macromolecule metabolic process#GO:0043170;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;spermatogenesis#GO:0007283;regulatory ncRNA-mediated gene silencing#GO:0031047;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;developmental maturation#GO:0021700;male gamete generation#GO:0048232;multicellular organismal process#GO:0032501;regionalization#GO:0003002;negative regulation of macromolecule metabolic process#GO:0010605;macromolecule biosynthetic process#GO:0009059;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;multicellular organismal reproductive process#GO:0048609;anatomical structure development#GO:0048856;sexual reproduction#GO:0019953;pattern specification process#GO:0007389;piRNA processing#GO:0034587;RNA biosynthetic process#GO:0032774;reproductive process#GO:0022414;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;anatomical structure maturation#GO:0071695;germ cell development#GO:0007281;developmental process involved in reproduction#GO:0003006;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;P granule#GO:0043186;membraneless organelle#GO:0043228 scaffold/adaptor protein#PC00226 HUMAN|HGNC=24330|UniProtKB=Q7Z7G2 Q7Z7G2 CPLX4 PTHR16705:SF7 COMPLEXIN COMPLEXIN-4 binding#GO:0005488;SNARE binding#GO:0000149;protein binding#GO:0005515 biological regulation#GO:0065007;cell-cell signaling#GO:0007267;neurotransmitter secretion#GO:0007269;establishment of localization#GO:0051234;synaptic vesicle cycle#GO:0099504;transport#GO:0006810;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;signal release from synapse#GO:0099643;chemical synaptic transmission#GO:0007268;cell communication#GO:0007154;localization#GO:0051179;secretion#GO:0046903;signal release#GO:0023061;trans-synaptic signaling#GO:0099537;neurotransmitter transport#GO:0006836;vesicle-mediated transport#GO:0016192;regulation of trans-synaptic signaling#GO:0099177;establishment of localization in cell#GO:0051649;synaptic vesicle exocytosis#GO:0016079;cellular process#GO:0009987;synaptic signaling#GO:0099536;regulation of transport#GO:0051049;exocytosis#GO:0006887;regulation of localization#GO:0032879;vesicle-mediated transport in synapse#GO:0099003;regulated exocytosis#GO:0045055;export from cell#GO:0140352;signaling#GO:0023052;regulation of cellular component organization#GO:0051128;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;secretion by cell#GO:0032940;cellular localization#GO:0051641;regulation of signaling#GO:0023051 axon terminus#GO:0043679;cell junction#GO:0030054;neuron projection#GO:0043005;presynapse#GO:0098793;membrane#GO:0016020;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;axon#GO:0030424;intracellular anatomical structure#GO:0005622;membrane protein complex#GO:0098796;cell projection#GO:0042995;neuron projection terminus#GO:0044306;terminal bouton#GO:0043195;plasma membrane bounded cell projection#GO:0120025;distal axon#GO:0150034;cellular anatomical structure#GO:0110165;synapse#GO:0045202;SNARE complex#GO:0031201 HUMAN|HGNC=3178|UniProtKB=P14138 P14138 EDN3 PTHR13874:SF11 ENDOTHELIN ENDOTHELIN-3 receptor ligand activity#GO:0048018;neuropeptide receptor binding#GO:0071855;signaling receptor regulator activity#GO:0030545;G protein-coupled receptor binding#GO:0001664;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;binding#GO:0005488;signaling receptor binding#GO:0005102;protein binding#GO:0005515;hormone activity#GO:0005179;molecular function activator activity#GO:0140677 regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;blood circulation#GO:0008015;positive regulation of biological process#GO:0048518;monoatomic ion homeostasis#GO:0050801;regulation of systemic arterial blood pressure#GO:0003073;regulation of blood pressure#GO:0008217;regulation of smooth muscle contraction#GO:0006940;cellular homeostasis#GO:0019725;intracellular calcium ion homeostasis#GO:0006874;intracellular chemical homeostasis#GO:0055082;system process#GO:0003008;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;muscle contraction#GO:0006936;regulation of system process#GO:0044057;regulation of anatomical structure size#GO:0090066;homeostatic process#GO:0042592;positive regulation of multicellular organismal process#GO:0051240;regulation of biological process#GO:0050789;muscle system process#GO:0003012;intracellular monoatomic ion homeostasis#GO:0006873;regulation of muscle system process#GO:0090257;regulation of biological quality#GO:0065008;inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;circulatory system process#GO:0003013;regulation of muscle contraction#GO:0006937 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 peptide hormone#PC00179 Endothelin signaling pathway#P00019>Big ET1-4#P00574;Endothelin signaling pathway#P00019>ET1-4#P00588 HUMAN|HGNC=34390|UniProtKB=A6NCE7 A6NCE7 MAP1LC3B2 PTHR10969:SF15 MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED MICROTUBULE-ASSOCIATED PROTEIN 1 LIGHT CHAIN 3 BETA-RELATED lipid binding#GO:0008289;protein binding#GO:0005515;enzyme binding#GO:0019899;binding#GO:0005488;microtubule binding#GO:0008017;ubiquitin protein ligase binding#GO:0031625;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;ubiquitin-like protein ligase binding#GO:0044389;phospholipid binding#GO:0005543 protein-containing complex disassembly#GO:0032984;catabolic process#GO:0009056;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;response to starvation#GO:0042594;cellular component organization#GO:0016043;vacuole organization#GO:0007033;process utilizing autophagic mechanism#GO:0061919;cellular component disassembly#GO:0022411;cellular response to stress#GO:0033554;organelle assembly#GO:0070925;macroautophagy#GO:0016236;cellular component assembly#GO:0022607;autophagy#GO:0006914;autophagosome organization#GO:1905037;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;response to nutrient levels#GO:0031667;response to stress#GO:0006950;protein-containing complex organization#GO:0043933;autophagosome assembly#GO:0000045;cellular component organization or biogenesis#GO:0071840;mitophagy#GO:0000423;cellular response to nutrient levels#GO:0031669;metabolic process#GO:0008152;cellular response to starvation#GO:0009267;autophagy of mitochondrion#GO:0000422;autophagosome maturation#GO:0097352 organelle#GO:0043226;cellular anatomical structure#GO:0110165;vacuole#GO:0005773;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;vacuolar membrane#GO:0005774;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;autophagosome membrane#GO:0000421;intracellular anatomical structure#GO:0005622;autophagosome#GO:0005776;intracellular organelle#GO:0043229 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=21653|UniProtKB=Q9NS56 Q9NS56 TOPORS PTHR46077:SF2 E3 UBIQUITIN-PROTEIN LIGASE TOPORS E3 UBIQUITIN-PROTEIN LIGASE TOPORS aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746 protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;protein sumoylation#GO:0016925;primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;cellular process#GO:0009987;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687 cilium#GO:0005929;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;ciliary transition zone#GO:0035869;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;non-motile cilium#GO:0097730;nuclear speck#GO:0016607;organelle lumen#GO:0043233;cell projection#GO:0042995;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;microtubule organizing center#GO:0005815;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;neuron projection#GO:0043005;nucleus#GO:0005634;photoreceptor cell cilium#GO:0097733;9+0 non-motile cilium#GO:0097731;microtubule cytoskeleton#GO:0015630;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;nuclear body#GO:0016604;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=34299|UniProtKB=Q68CR7 Q68CR7 LRRC66 PTHR24366:SF156 IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS LEUCINE-RICH REPEAT-CONTAINING PROTEIN 66 cognition#GO:0050890;nervous system process#GO:0050877;multicellular organismal process#GO:0032501;system process#GO:0003008 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 immunoglobulin superfamily cell adhesion molecule#PC00125 HUMAN|HGNC=30222|UniProtKB=O95397 O95397 PLEKHA8P1 PTHR10219:SF75 GLYCOLIPID TRANSFER PROTEIN-RELATED PROTEIN PLEKHA9-RELATED phospholipid binding#GO:0005543;transporter activity#GO:0005215;phospholipid transfer activity#GO:0120014;lipid binding#GO:0008289;lipid transfer activity#GO:0120013;molecular carrier activity#GO:0140104;ion binding#GO:0043167;lipid carrier activity#GO:0005319;binding#GO:0005488;small molecule binding#GO:0036094;anion binding#GO:0043168 cellular localization#GO:0051641;localization#GO:0051179;lipid localization#GO:0010876;ceramide transport#GO:0035627;cellular component organization#GO:0016043;intermembrane lipid transfer#GO:0120009;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;transport#GO:0006810;intracellular transport#GO:0046907;membrane organization#GO:0061024;lipid transport#GO:0006869;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;nitrogen compound transport#GO:0071705;macromolecule localization#GO:0033036 membrane#GO:0016020;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 transfer/carrier protein#PC00219 HUMAN|HGNC=7854|UniProtKB=Q13287 Q13287 NMI PTHR15225:SF4 INTERFERON-INDUCED PROTEIN 35/NMI N-MYC/STAT INTERACTING PROTEIN N-MYC-INTERACTOR cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 transcription cofactor#PC00217 HUMAN|HGNC=11180|UniProtKB=P04179 P04179 SOD2 PTHR11404:SF41 SUPEROXIDE DISMUTASE 2 SUPEROXIDE DISMUTASE [MN], MITOCHONDRIAL binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;transition metal ion binding#GO:0046914;metal ion binding#GO:0046872;cation binding#GO:0043169;catalytic activity#GO:0003824;antioxidant activity#GO:0016209;oxidoreductase activity#GO:0016491 mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=34442|UniProtKB=A6NJI1 A6NJI1 C11orf86 PTHR31831:SF1 HYPOTHETICAL PROTEIN LOC689065 SIMILAR TO HUMAN CHROMOSOME 11 OPEN READING FRAME 86 HUMAN|HGNC=18273|UniProtKB=Q96PN7 Q96PN7 TRERF1 PTHR16089:SF19 REST COREPRESSOR COREST PROTEIN-RELATED TRANSCRIPTIONAL-REGULATING FACTOR 1 transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714;transcription regulator activity#GO:0140110 negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219 transcription regulator complex#GO:0005667;nuclear protein-containing complex#GO:0140513;protein-containing complex#GO:0032991;nucleus#GO:0005634;histone deacetylase complex#GO:0000118;membrane-enclosed lumen#GO:0031974;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle lumen#GO:0043233 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=5198|UniProtKB=Q9Y662 Q9Y662 HS3ST3B1 PTHR10605:SF7 HEPARAN SULFATE SULFOTRANSFERASE HEPARAN SULFATE GLUCOSAMINE 3-O-SULFOTRANSFERASE 3B1 transferase activity, transferring sulphur-containing groups#GO:0016782;sulfotransferase activity#GO:0008146;catalytic activity#GO:0003824;transferase activity#GO:0016740 transferase#PC00220;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=18639|UniProtKB=O95208 O95208 EPN2 PTHR12276:SF50 EPSIN/ENT-RELATED EPSIN-2 clathrin binding#GO:0030276;phospholipid binding#GO:0005543;binding#GO:0005488;protein binding#GO:0005515;lipid binding#GO:0008289 transport#GO:0006810;receptor-mediated endocytosis#GO:0006898;localization#GO:0051179;import into cell#GO:0098657;establishment of localization#GO:0051234;cellular process#GO:0009987;clathrin-dependent endocytosis#GO:0072583;endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192 coated vesicle membrane#GO:0030662;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;clathrin coat#GO:0030118;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;coated vesicle#GO:0030135;cytoplasmic vesicle#GO:0031410;coated membrane#GO:0048475;membrane coat#GO:0030117;intracellular organelle#GO:0043229;endosome#GO:0005768;plasma membrane#GO:0005886;vesicle coat#GO:0030120;cytoplasm#GO:0005737;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;cell periphery#GO:0071944;vesicle membrane#GO:0012506;membrane#GO:0016020;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;clathrin-coated vesicle membrane#GO:0030665;clathrin vesicle coat#GO:0030125;clathrin-coated vesicle#GO:0030136 membrane traffic protein#PC00150;membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=5238|UniProtKB=P11021 P11021 HSPA5 PTHR19375:SF380 HEAT SHOCK PROTEIN 70KDA ENDOPLASMIC RETICULUM CHAPERONE BIP hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;ATP-dependent activity#GO:0140657;hydrolase activity#GO:0016787;protein binding#GO:0005515;ATP hydrolysis activity#GO:0016887;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817;heat shock protein binding#GO:0031072;ribonucleoside triphosphate phosphatase activity#GO:0017111 cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;protein refolding#GO:0042026;response to unfolded protein#GO:0006986;regulation of biological process#GO:0050789;response to topologically incorrect protein#GO:0035966;signaling#GO:0023052;protein folding#GO:0006457;response to stimulus#GO:0050896;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;signal transduction#GO:0007165;cellular process#GO:0009987;response to stress#GO:0006950;proteasomal protein catabolic process#GO:0010498;response to chemical#GO:0042221;protein maturation#GO:0051604;gene expression#GO:0010467;cellular response to topologically incorrect protein#GO:0035967;response to endoplasmic reticulum stress#GO:0034976;cellular response to unfolded protein#GO:0034620;ERAD pathway#GO:0036503;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;protein metabolic process#GO:0019538;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;endoplasmic reticulum unfolded protein response#GO:0030968;biosynthetic process#GO:0009058;biological regulation#GO:0065007 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;endoplasmic reticulum protein-containing complex#GO:0140534;nucleus#GO:0005634;membrane#GO:0016020;membrane-enclosed lumen#GO:0031974;endoplasmic reticulum lumen#GO:0005788;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505 chaperone#PC00072;Hsp70 family chaperone#PC00027 Apoptosis signaling pathway#P00006>HSP70#P00321;Parkinson disease#P00049>Hsp70#P01208 HUMAN|HGNC=20208|UniProtKB=Q96HA9 Q96HA9 PEX11G PTHR20990:SF1 PEROXISOMAL BIOGENESIS FACTOR 11 PEROXISOMAL MEMBRANE PROTEIN 11C organelle organization#GO:0006996;cellular component organization#GO:0016043;peroxisome organization#GO:0007031;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;organelle fission#GO:0048285 bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;peroxisomal membrane#GO:0005778;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;peroxisome#GO:0005777;microbody#GO:0042579 HUMAN|HGNC=44659|UniProtKB=Q96MC4 Q96MC4 CEP295NL PTHR21553:SF33 ALMS1-RELATED CEP295 N-TERMINAL-LIKE PROTEIN regulation of organelle organization#GO:0033043;regulation of organelle assembly#GO:1902115;regulation of biological process#GO:0050789;regulation of cellular component biogenesis#GO:0044087;regulation of cell cycle#GO:0051726;biological regulation#GO:0065007;regulation of cell cycle process#GO:0010564;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of microtubule-based process#GO:0032886 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;centrosome#GO:0005813;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;centriole#GO:0005814;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;cytosol#GO:0005829 HUMAN|HGNC=10446|UniProtKB=P55042 P55042 RRAD PTHR45775:SF3 RAD, GEM/KIR FAMILY MEMBER 2, ISOFORM C GTP-BINDING PROTEIN RAD nucleoside phosphate binding#GO:1901265;binding#GO:0005488;guanyl nucleotide binding#GO:0019001;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;carbohydrate derivative binding#GO:0097367;calcium channel regulator activity#GO:0005246;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;ribonucleotide binding#GO:0032553;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;transporter regulator activity#GO:0141108;channel regulator activity#GO:0016247;ion channel regulator activity#GO:0099106;molecular function regulator activity#GO:0098772;nucleotide binding#GO:0000166 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HUMAN|HGNC=30454|UniProtKB=Q9NSQ0 Q9NSQ0 RRP7BP PTHR13191:SF0 RIBOSOMAL RNA PROCESSING PROTEIN 7-RELATED RIBOSOMAL RNA-PROCESSING PROTEIN 7 HOMOLOG A-RELATED RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;rRNA processing#GO:0006364;protein-RNA complex assembly#GO:0022618;organelle assembly#GO:0070925;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;ribosomal small subunit assembly#GO:0000028;rRNA metabolic process#GO:0016072;ribonucleoprotein complex biogenesis#GO:0022613;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;ribosome assembly#GO:0042255;ribosome biogenesis#GO:0042254;RNA processing#GO:0006396;cellular component assembly#GO:0022607;gene expression#GO:0010467;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;protein-RNA complex organization#GO:0071826;ribosomal small subunit biogenesis#GO:0042274;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654 90S preribosome#GO:0030686;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;preribosome#GO:0030684;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;nucleolus#GO:0005730;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513 RNA metabolism protein#PC00031 HUMAN|HGNC=43622|UniProtKB=A0A1W2PQJ5 A0A1W2PQJ5 SSU72L3 PTHR20383:SF10 RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE SSU72 LIKE PROTEIN 1-RELATED phosphoprotein phosphatase activity#GO:0004721;protein serine/threonine phosphatase activity#GO:0004722;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 transcription by RNA polymerase II#GO:0006366;nucleobase-containing compound biosynthetic process#GO:0034654;termination of RNA polymerase II transcription#GO:0006369;mRNA 3'-end processing#GO:0031124;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;DNA-templated transcription termination#GO:0006353;mRNA processing#GO:0006397;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;DNA-templated transcription#GO:0006351;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774 nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mRNA cleavage and polyadenylation specificity factor complex#GO:0005847;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;mRNA cleavage factor complex#GO:0005849;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 protein phosphatase#PC00195 HUMAN|HGNC=290|UniProtKB=P35626 P35626 GRK3 PTHR24355:SF17 G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE G PROTEIN-COUPLED RECEPTOR KINASE 3 G protein-coupled receptor binding#GO:0001664;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;signaling receptor binding#GO:0005102;binding#GO:0005488;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein binding#GO:0005515 negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of G protein-coupled receptor signaling pathway#GO:0008277;cellular process#GO:0009987;signal transduction#GO:0007165;negative regulation of response to stimulus#GO:0048585;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signaling#GO:0023057;G protein-coupled receptor signaling pathway#GO:0007186;regulation of signaling#GO:0023051;cell communication#GO:0007154;negative regulation of cell communication#GO:0010648;negative regulation of G protein-coupled receptor signaling pathway#GO:0045744;negative regulation of biological process#GO:0048519;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of cell communication#GO:0010646;signaling#GO:0023052 non-receptor serine/threonine protein kinase#PC00167 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GPRK#P00741;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GPRK#P00701;Angiotensin II-stimulated signaling through G proteins and beta-arrestin#P05911>GRK3#P05941;Parkinson disease#P00049>GRK#P01234 HUMAN|HGNC=28725|UniProtKB=Q8IXN7 Q8IXN7 RIMKLA PTHR21621:SF1 RIBOSOMAL PROTEIN S6 MODIFICATION PROTEIN N-ACETYLASPARTYLGLUTAMATE SYNTHASE A ligase activity, forming carbon-nitrogen bonds#GO:0016879;catalytic activity#GO:0003824;ligase activity#GO:0016874 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 translational protein#PC00263;ribosomal protein#PC00202 HUMAN|HGNC=17966|UniProtKB=Q9Y592 Q9Y592 CEP83 PTHR23170:SF2 NY-REN-58 ANTIGEN CENTROSOMAL PROTEIN OF 83 KDA cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;plasma membrane bounded cell projection assembly#GO:0120031;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;establishment of localization in cell#GO:0051649;cell projection assembly#GO:0030031;cellular process#GO:0009987;localization#GO:0051179;cellular localization#GO:0051641;cilium organization#GO:0044782;organelle assembly#GO:0070925;organelle localization#GO:0051640;cell projection organization#GO:0030030;establishment of organelle localization#GO:0051656;centrosome localization#GO:0051642;cellular component organization#GO:0016043;cilium assembly#GO:0060271 endomembrane system#GO:0012505;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;centriole#GO:0005814;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630;ciliary transition fiber#GO:0097539;membraneless organelle#GO:0043228;intracellular protein-containing complex#GO:0140535;Golgi apparatus#GO:0005794;microtubule organizing center#GO:0005815;centrosome#GO:0005813;cytoskeleton#GO:0005856;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cilium#GO:0005929 HUMAN|HGNC=33848|UniProtKB=Q86WW8 Q86WW8 COA5 PTHR28627:SF1 CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5 CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5 cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;respiratory chain complex IV assembly#GO:0008535;mitochondrial respiratory chain complex IV assembly#GO:0033617;cytochrome complex assembly#GO:0017004;cellular component assembly#GO:0022607;mitochondrion organization#GO:0007005;mitochondrial respiratory chain complex assembly#GO:0033108;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 chaperone#PC00072 HUMAN|HGNC=30346|UniProtKB=Q9NYV6 Q9NYV6 RRN3 PTHR12790:SF0 TRANSCRIPTION INITIATION FACTOR IA RRN3 RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN3-RELATED biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;transcription by RNA polymerase I#GO:0006360;transcription initiation at RNA polymerase I promoter#GO:0006361;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;DNA-templated transcription initiation#GO:0006352;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 general transcription factor#PC00259 General transcription by RNA polymerase I#P00022>RNA Polymerase I Complex#P00652 HUMAN|HGNC=3416|UniProtKB=P19235 P19235 EPOR PTHR23037:SF28 CYTOKINE RECEPTOR ERYTHROPOIETIN RECEPTOR cytokine receptor activity#GO:0004896;transmembrane signaling receptor activity#GO:0004888;immune receptor activity#GO:0140375;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 signaling#GO:0023052;biological regulation#GO:0065007;response to chemical#GO:0042221;response to cytokine#GO:0034097;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cellular response to cytokine stimulus#GO:0071345;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to peptide#GO:1901652;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;cytokine-mediated signaling pathway#GO:0019221 cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell surface#GO:0009986;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897 transmembrane signal receptor#PC00197 HUMAN|HGNC=21265|UniProtKB=Q9NZP8 Q9NZP8 C1RL PTHR24255:SF26 COMPLEMENT COMPONENT 1, S SUBCOMPONENT-RELATED COMPLEMENT C1R SUBCOMPONENT-LIKE PROTEIN catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;serine-type peptidase activity#GO:0008236 primary metabolic process#GO:0044238;zymogen activation#GO:0031638;cellular process#GO:0009987;protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;proteolysis#GO:0006508;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 serine protease#PC00203 HUMAN|HGNC=5759|UniProtKB=A0A087WSZ0 A0A087WSZ0 IGKV1D-8 PTHR23267:SF320 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN KAPPA VARIABLE 1-8-RELATED immune system process#GO:0002376;immune response#GO:0006955;response to stimulus#GO:0050896 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=4456|UniProtKB=P43304 P43304 GPD2 PTHR11985:SF29 GLYCEROL-3-PHOSPHATE DEHYDROGENASE GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614 phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;pyridine-containing compound metabolic process#GO:0072524;nucleotide metabolic process#GO:0009117;NAD+ metabolic process#GO:0019674;organophosphate metabolic process#GO:0019637;carbohydrate derivative metabolic process#GO:1901135;nicotinamide nucleotide metabolic process#GO:0046496;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086 mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 dehydrogenase#PC00092 HUMAN|HGNC=20429|UniProtKB=Q8N7Q3 Q8N7Q3 ZNF676 PTHR24384:SF112 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED ZINC FINGER PROTEIN 676 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218 HUMAN|HGNC=18657|UniProtKB=Q5SRH9 Q5SRH9 TTC39A PTHR31859:SF3 TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER TETRATRICOPEPTIDE REPEAT PROTEIN 39A HUMAN|HGNC=48955|UniProtKB=C9J7I0 C9J7I0 UMAD1 PTHR36291:SF1 UBAP1-MVB12-ASSOCIATED (UMA)-DOMAIN CONTAINING PROTEIN 1 UBAP1-MVB12-ASSOCIATED (UMA)-DOMAIN CONTAINING PROTEIN 1 HUMAN|HGNC=14869|UniProtKB=Q9BWW9 Q9BWW9 APOL5 PTHR14096:SF6 APOLIPOPROTEIN L APOLIPOPROTEIN L5 lipid binding#GO:0008289;binding#GO:0005488 membrane#GO:0016020;cellular anatomical structure#GO:0110165 apolipoprotein#PC00052;transfer/carrier protein#PC00219 HUMAN|HGNC=11742|UniProtKB=P05549 P05549 TFAP2A PTHR10812:SF8 TRANSCRIPTION FACTOR AP-2 TRANSCRIPTION FACTOR AP-2-ALPHA DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription activator activity#GO:0001216;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690 positive regulation of biosynthetic process#GO:0009891;regulation of cell population proliferation#GO:0042127;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of cellular process#GO:0048522;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of apoptotic process#GO:0043066;positive regulation of DNA-templated transcription#GO:0045893;multicellular organismal process#GO:0032501;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;animal gross anatomical part developmental process#GO:0160108;skeletal system development#GO:0001501;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of apoptotic process#GO:0042981;multicellular organism development#GO:0007275;animal organ development#GO:0048513;renal system development#GO:0072001;kidney development#GO:0001822;positive regulation of biological process#GO:0048518;negative regulation of programmed cell death#GO:0043069;positive regulation of macromolecule metabolic process#GO:0010604;nervous system development#GO:0007399 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 RNA metabolism protein#PC00031;general transcription factor#PC00259 HUMAN|HGNC=28230|UniProtKB=Q9BRT3 Q9BRT3 MIEN1 PTHR15124:SF27 SELENOPROTEIN W MIGRATION AND INVASION ENHANCER 1 regulation of cellular component biogenesis#GO:0044087;regulation of cellular process#GO:0050794;regulation of plasma membrane bounded cell projection assembly#GO:0120032;regulation of cellular component organization#GO:0051128;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;regulation of cell projection assembly#GO:0060491;positive regulation of cell projection organization#GO:0031346;positive regulation of cellular component organization#GO:0051130;biological regulation#GO:0065007;positive regulation of cellular component biogenesis#GO:0044089;negative regulation of apoptotic process#GO:0043066;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;negative regulation of programmed cell death#GO:0043069;regulation of filopodium assembly#GO:0051489;regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of apoptotic process#GO:0042981;negative regulation of cellular process#GO:0048523;regulation of cell projection organization#GO:0031344 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 HUMAN|HGNC=33738|UniProtKB=Q86X51 Q86X51 EZHIP PTHR22467:SF5 EZH INHIBITORY PROTEIN-RELATED EZH INHIBITORY PROTEIN nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=30600|UniProtKB=Q5T124 Q5T124 UBXN11 PTHR23333:SF4 UBX DOMAIN CONTAINING PROTEIN UBX DOMAIN-CONTAINING PROTEIN 11 protein binding#GO:0005515;binding#GO:0005488;ubiquitin binding#GO:0043130 proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152 protein-binding activity modulator#PC00095 HUMAN|HGNC=735|UniProtKB=Q13510 Q13510 ASAH1 PTHR28583:SF1 ACID AMIDASE ACID CERAMIDASE catalytic activity#GO:0003824;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity#GO:0016787 cysteine protease#PC00081 HUMAN|HGNC=25769|UniProtKB=Q8N9T8 Q8N9T8 KRI1 PTHR14490:SF5 ZINC FINGER, ZZ TYPE PROTEIN KRI1 HOMOLOG RNA biosynthetic process#GO:0032774;maturation of 5.8S rRNA#GO:0000460;ribonucleoprotein complex biogenesis#GO:0022613;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;maturation of SSU-rRNA#GO:0030490;cellular component biogenesis#GO:0044085;endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000479;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;ribosomal small subunit biogenesis#GO:0042274;endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000447 membraneless organelle#GO:0043228;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;preribosome#GO:0030684;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;nucleolus#GO:0005730;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;organelle lumen#GO:0043233;90S preribosome#GO:0030686 HUMAN|HGNC=12401|UniProtKB=P33981 P33981 TTK PTHR22974:SF21 MIXED LINEAGE PROTEIN KINASE DUAL SPECIFICITY PROTEIN KINASE TTK catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 mitotic spindle assembly checkpoint signaling#GO:0007094;signal transduction#GO:0007165;cellular process#GO:0009987;negative regulation of sister chromatid segregation#GO:0033046;regulation of cell cycle process#GO:0010564;negative regulation of mitotic cell cycle phase transition#GO:1901991;cell cycle checkpoint signaling#GO:0000075;regulation of chromosome separation#GO:1905818;negative regulation of mitotic sister chromatid segregation#GO:0033048;regulation of chromosome segregation#GO:0051983;negative regulation of metaphase/anaphase transition of cell cycle#GO:1902100;chromosome segregation#GO:0007059;meiotic cell cycle#GO:0051321;negative regulation of chromosome segregation#GO:0051985;negative regulation of cell cycle#GO:0045786;regulation of biological process#GO:0050789;negative regulation of mitotic nuclear division#GO:0045839;regulation of meiotic cell cycle#GO:0051445;cell cycle process#GO:0022402;regulation of organelle organization#GO:0033043;negative regulation of biological process#GO:0048519;negative regulation of cell cycle phase transition#GO:1901988;meiotic cell cycle process#GO:1903046;regulation of cell cycle#GO:0051726;signaling#GO:0023052;regulation of sister chromatid segregation#GO:0033045;response to stimulus#GO:0050896;regulation of cellular component organization#GO:0051128;negative regulation of mitotic sister chromatid separation#GO:2000816;negative regulation of mitotic cell cycle#GO:0045930;regulation of mitotic cell cycle phase transition#GO:1901990;regulation of mitotic cell cycle#GO:0007346;biological regulation#GO:0065007;negative regulation of nuclear division#GO:0051784;regulation of nuclear division#GO:0051783;regulation of reproductive process#GO:2000241;regulation of mitotic metaphase/anaphase transition#GO:0030071;negative regulation of cell cycle process#GO:0010948;regulation of chromosome organization#GO:0033044;negative regulation of cellular process#GO:0048523;negative regulation of chromosome separation#GO:1905819;mitotic cell cycle process#GO:1903047;regulation of mitotic nuclear division#GO:0007088;regulation of mitotic sister chromatid separation#GO:0010965;cellular response to stimulus#GO:0051716;negative regulation of mitotic metaphase/anaphase transition#GO:0045841;cell cycle#GO:0007049;regulation of cell cycle phase transition#GO:1901987;mitotic cell cycle checkpoint signaling#GO:0007093;negative regulation of organelle organization#GO:0010639;negative regulation of cellular component organization#GO:0051129;reproductive process#GO:0022414;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;mitotic cell cycle#GO:0000278;regulation of cellular process#GO:0050794;sexual reproduction#GO:0019953;negative regulation of chromosome organization#GO:2001251;intracellular signal transduction#GO:0035556;regulation of mitotic sister chromatid segregation#GO:0033047;cell communication#GO:0007154 membraneless organelle#GO:0043228;chromosome, centromeric region#GO:0000775;condensed chromosome#GO:0000793;intracellular membraneless organelle#GO:0043232;supramolecular complex#GO:0099080;nucleus#GO:0005634;condensed chromosome, centromeric region#GO:0000779;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;kinetochore#GO:0000776;chromosome#GO:0005694 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=26383|UniProtKB=Q8N136 Q8N136 DAW1 PTHR44156:SF33 SUPERNUMERARY LIMBS, ISOFORM B-RELATED DYNEIN ASSEMBLY FACTOR WITH WD REPEAT DOMAINS 1 protein-containing complex assembly#GO:0065003;determination of left/right symmetry#GO:0007368;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cell projection organization#GO:0030030;microtubule bundle formation#GO:0001578;axonemal dynein complex assembly#GO:0070286;pattern specification process#GO:0007389;organelle assembly#GO:0070925;cilium organization#GO:0044782;axoneme assembly#GO:0035082;anatomical structure development#GO:0048856;microtubule cytoskeleton organization#GO:0000226;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;plasma membrane bounded cell projection organization#GO:0120036;determination of bilateral symmetry#GO:0009855;cytoskeleton organization#GO:0007010;regionalization#GO:0003002;multicellular organismal process#GO:0032501;cellular component assembly#GO:0022607;developmental process#GO:0032502;left/right pattern formation#GO:0060972;specification of symmetry#GO:0009799;plasma membrane bounded cell projection assembly#GO:0120031;protein-containing complex organization#GO:0043933;microtubule-based process#GO:0007017;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840 HUMAN|HGNC=31295|UniProtKB=A6NJZ3 A6NJZ3 OR6C65 PTHR26454:SF15 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 6C65 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=4221|UniProtKB=Q6KF10 Q6KF10 GDF6 PTHR11848:SF43 TGF-BETA FAMILY GROWTH_DIFFERENTIATION FACTOR 6 signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;cytokine activity#GO:0005125 multicellular organism development#GO:0007275;animal organ development#GO:0048513;response to BMP#GO:0071772;developmental process#GO:0032502;cellular response to BMP stimulus#GO:0071773;cell surface receptor signaling pathway#GO:0007166;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;biological regulation#GO:0065007;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;multicellular organismal process#GO:0032501;signal transduction#GO:0007165;cellular process#GO:0009987;kidney development#GO:0001822;renal system development#GO:0072001;cellular response to growth factor stimulus#GO:0071363;system development#GO:0048731;cell communication#GO:0007154;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;animal gross anatomical part developmental process#GO:0160108;signaling#GO:0023052;cellular response to endogenous stimulus#GO:0071495;response to growth factor#GO:0070848;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;BMP signaling pathway#GO:0030509;response to endogenous stimulus#GO:0009719 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 growth factor#PC00112 TGF-beta signaling pathway#P00052>TGFbeta#P01286 HUMAN|HGNC=23677|UniProtKB=Q5SZB4 Q5SZB4 C9orf50 PTHR36865:SF1 RIKEN CDNA 1700001O22 GENE RIKEN CDNA 1700001O22 GENE cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=28707|UniProtKB=Q9BTK6 Q9BTK6 PAGR1 PTHR28467:SF1 PAXIP1-ASSOCIATED GLUTAMATE-RICH PROTEIN 1 PAXIP1-ASSOCIATED GLUTAMATE-RICH PROTEIN 1 HUMAN|HGNC=2314|UniProtKB=Q99829 Q99829 CPNE1 PTHR10857:SF2 COPINE COPINE-1 phospholipid binding#GO:0005543;binding#GO:0005488;lipid binding#GO:0008289 response to chemical#GO:0042221;positive regulation of response to stimulus#GO:0048584;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of response to cytokine stimulus#GO:0060759;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;regulation of canonical NF-kappaB signal transduction#GO:0043122;regulation of cytokine-mediated signaling pathway#GO:0001959;response to metal ion#GO:0010038;regulation of response to stimulus#GO:0048583;response to stimulus#GO:0050896;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to calcium ion#GO:0051592;positive regulation of signaling#GO:0023056;positive regulation of cytokine-mediated signaling pathway#GO:0001961;cellular response to chemical stimulus#GO:0070887;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 calcium-binding protein#PC00060 HUMAN|HGNC=3624|UniProtKB=Q15485 Q15485 FCN2 PTHR19143:SF433 FIBRINOGEN/TENASCIN/ANGIOPOEITIN FICOLIN-2 extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HUMAN|HGNC=11593|UniProtKB=O75333 O75333 TBX10 PTHR11267:SF102 T-BOX PROTEIN-RELATED T-BOX TRANSCRIPTION FACTOR TBX10 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;cell fate specification#GO:0001708;developmental process#GO:0032502;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;cell fate commitment#GO:0045165 intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229 immunoglobulin fold transcription factor#PC00251;Rel homology transcription factor#PC00252 HUMAN|HGNC=67|UniProtKB=P28288 P28288 ABCD3 PTHR11384:SF62 ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 3 transporter activity#GO:0005215;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626;nucleoside phosphate binding#GO:1901265;ATP binding#GO:0005524;binding#GO:0005488;transmembrane transporter activity#GO:0022857;nucleotide binding#GO:0000166;monocarboxylic acid transmembrane transporter activity#GO:0008028;active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399;carboxylic acid transmembrane transporter activity#GO:0046943;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094 organelle organization#GO:0006996;cellular process#GO:0009987;lipid catabolic process#GO:0016042;establishment of localization in cell#GO:0051649;metabolic process#GO:0008152;carboxylic acid transport#GO:0046942;organic acid transport#GO:0015849;fatty acid oxidation#GO:0019395;cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;small molecule metabolic process#GO:0044281;small molecule catabolic process#GO:0044282;very long-chain fatty acid metabolic process#GO:0000038;lipid localization#GO:0010876;oxoacid metabolic process#GO:0043436;peroxisome organization#GO:0007031;cellular localization#GO:0051641;transmembrane transport#GO:0055085;fatty acid catabolic process#GO:0009062;macromolecule localization#GO:0033036;carboxylic acid catabolic process#GO:0046395;monocarboxylic acid catabolic process#GO:0072329;lipid transport#GO:0006869;fatty acid metabolic process#GO:0006631;intracellular transport#GO:0046907;transport#GO:0006810;lipid metabolic process#GO:0006629;fatty acid beta-oxidation#GO:0006635;establishment of localization#GO:0051234;lipid modification#GO:0030258;primary metabolic process#GO:0044238;catabolic process#GO:0009056;carboxylic acid transmembrane transport#GO:1905039;lipid oxidation#GO:0034440;fatty acid transport#GO:0015908;localization#GO:0051179;monocarboxylic acid transport#GO:0015718;peroxisomal transport#GO:0043574 peroxisome#GO:0005777;membrane#GO:0016020;microbody#GO:0042579;organelle#GO:0043226;peroxisomal membrane#GO:0005778;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090 ATP-binding cassette (ABC) transporter#PC00003;primary active transporter#PC00068 HUMAN|HGNC=28061|UniProtKB=Q6NXP0 Q6NXP0 EFCAB12 PTHR47225:SF1 EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 12 EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 12 calmodulin-related#PC00061;calcium-binding protein#PC00060 HUMAN|HGNC=9670|UniProtKB=P10586 P10586 PTPRF PTHR19134:SF203 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE F catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725;phosphoprotein phosphatase activity#GO:0004721 animal gross anatomical part developmental process#GO:0160108;synapse organization#GO:0050808;cell adhesion#GO:0007155;cell communication#GO:0007154;anatomical structure development#GO:0048856;synaptic membrane adhesion#GO:0099560;system development#GO:0048731;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell junction organization#GO:0034330;signaling#GO:0023052;developmental process#GO:0032502;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cell-cell adhesion#GO:0098609;signal transduction#GO:0007165;cellular process#GO:0009987;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;nervous system development#GO:0007399 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HUMAN|HGNC=26742|UniProtKB=Q8N9F0 Q8N9F0 NAT8L PTHR13947:SF11 GNAT FAMILY N-ACETYLTRANSFERASE N-ACETYLASPARTATE SYNTHETASE acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;N-acetyltransferase activity#GO:0008080;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740;acetyltransferase activity#GO:0016407 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;organelle envelope#GO:0031967;mitochondrial envelope#GO:0005740;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 acetyltransferase#PC00038 HUMAN|HGNC=15947|UniProtKB=Q9BZF9 Q9BZF9 UACA PTHR24173:SF23 ANKYRIN REPEAT CONTAINING UVEAL AUTOANTIGEN WITH COILED-COIL DOMAINS AND ANKYRIN REPEATS cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of inflammatory response#GO:0050727;regulation of defense response#GO:0031347;negative regulation of defense response#GO:0031348;regulation of cellular process#GO:0050794;negative regulation of inflammatory response#GO:0050728;regulation of cell communication#GO:0010646;programmed cell death#GO:0012501;cell death#GO:0008219;cellular response to stimulus#GO:0051716;apoptotic signaling pathway#GO:0097190;regulation of response to stress#GO:0080134;negative regulation of cellular process#GO:0048523;DNA damage response#GO:0006974;regulation of response to stimulus#GO:0048583;negative regulation of response to stimulus#GO:0048585;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of intracellular signal transduction#GO:1902532;intrinsic apoptotic signaling pathway#GO:0097193;negative regulation of cell communication#GO:0010648;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;cellular response to stress#GO:0033554;regulation of signaling#GO:0023051;response to stimulus#GO:0050896;signaling#GO:0023052;negative regulation of biological process#GO:0048519;regulation of non-canonical NF-kappaB signal transduction#GO:1901222;regulation of biological process#GO:0050789;apoptotic process#GO:0006915;regulation of response to external stimulus#GO:0032101;negative regulation of response to external stimulus#GO:0032102;negative regulation of signal transduction#GO:0009968;intrinsic apoptotic signaling pathway in response to DNA damage#GO:0008630;response to stress#GO:0006950;signal transduction#GO:0007165;cellular process#GO:0009987 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;cytosol#GO:0005829 scaffold/adaptor protein#PC00226 HUMAN|HGNC=14651|UniProtKB=O43447 O43447 PPIH PTHR11071:SF443 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE H membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229 chaperone#PC00072 HUMAN|HGNC=29521|UniProtKB=Q99622 Q99622 C12orf57 PTHR13463:SF3 PROTEIN C10 PROTEIN C10 multicellular organismal process#GO:0032501;anatomical structure development#GO:0048856;multicellular organism development#GO:0007275;post-embryonic development#GO:0009791;developmental process#GO:0032502 HUMAN|HGNC=51238|UniProtKB=E9PRG8 E9PRG8 RSMC PTHR14554:SF1 GENE, 49416-RELATED 28S RRNA_RIBOSOME AND SORORIN MICRO-COFACTOR HUMAN|HGNC=7460|UniProtKB=P03901 P03901 MT-ND4L PTHR11434:SF0 NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT ND4L NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4L cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;oxidoreductase complex#GO:1990204;membrane#GO:0016020;membrane protein complex#GO:0098796;respiratory chain complex#GO:0098803;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;respiratory chain complex I#GO:0045271;catalytic complex#GO:1902494 oxidoreductase#PC00176 HUMAN|HGNC=6809|UniProtKB=O15479 O15479 MAGEB2 PTHR11736:SF152 MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN MELANOMA-ASSOCIATED ANTIGEN B2 negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 scaffold/adaptor protein#PC00226 HUMAN|HGNC=3760|UniProtKB=Q9NZU1 Q9NZU1 FLRT1 PTHR45712:SF15 AGAP008170-PA LEUCINE-RICH REPEAT TRANSMEMBRANE PROTEIN FLRT1 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=22310|UniProtKB=Q8IV56 Q8IV56 PRR15 PTHR14581:SF4 FAMILY NOT NAMED PROLINE-RICH PROTEIN 15 HUMAN|HGNC=13485|UniProtKB=Q9BXU7 Q9BXU7 USP26 PTHR24006:SF911 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 26 hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;cysteine-type deubiquitinase activity#GO:0004843 biological regulation#GO:0065007;mitotic cell cycle#GO:0000278;cell cycle phase transition#GO:0044770;cell cycle G1/S phase transition#GO:0044843;regulation of protein stability#GO:0031647;cellular process#GO:0009987;cell cycle process#GO:0022402;cell cycle#GO:0007049;mitotic cell cycle process#GO:1903047;regulation of biological quality#GO:0065008;mitotic cell cycle phase transition#GO:0044772;G1/S transition of mitotic cell cycle#GO:0000082 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 protease#PC00190;cysteine protease#PC00081 HUMAN|HGNC=24676|UniProtKB=Q14296 Q14296 FASTK PTHR21228:SF4 FAST LEU-RICH DOMAIN-CONTAINING FAS-ACTIVATED SERINE_THREONINE KINASE nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;macromolecule biosynthetic process#GO:0009059;mitochondrial RNA processing#GO:0000963;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;post-transcriptional regulation of gene expression#GO:0010608;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;RNA biosynthetic process#GO:0032774;regulation of RNA stability#GO:0043487;mitochondrial RNA metabolic process#GO:0000959;mitochondrial gene expression#GO:0140053;regulation of RNA metabolic process#GO:0051252;cellular process#GO:0009987;gene expression#GO:0010467;RNA processing#GO:0006396;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;regulation of mRNA metabolic process#GO:1903311;regulation of mRNA catabolic process#GO:0061013;regulation of biological process#GO:0050789;regulation of mRNA stability#GO:0043488;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;regulation of biological quality#GO:0065008 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;organelle lumen#GO:0043233;membraneless organelle#GO:0043228;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;membrane-enclosed lumen#GO:0031974 RNA processing factor#PC00147 HUMAN|HGNC=29151|UniProtKB=Q9Y2E6 Q9Y2E6 DTX4 PTHR12622:SF5 DELTEX-RELATED E3 UBIQUITIN-PROTEIN LIGASE DTX4 catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987 nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=17989|UniProtKB=Q96S37 Q96S37 SLC22A12 PTHR24064:SF205 SOLUTE CARRIER FAMILY 22 MEMBER SOLUTE CARRIER FAMILY 22 MEMBER 12 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;transport#GO:0006810;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 secondary carrier transporter#PC00258 HUMAN|HGNC=19108|UniProtKB=P59542 P59542 TAS2R19 PTHR11394:SF139 TASTE RECEPTOR TYPE 2 TASTE RECEPTOR TYPE 2 MEMBER 19-RELATED molecular transducer activity#GO:0060089;bitter taste receptor activity#GO:0033038;signaling receptor activity#GO:0038023;taste receptor activity#GO:0008527;transmembrane signaling receptor activity#GO:0004888 detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;sensory perception of taste#GO:0050909;detection of chemical stimulus involved in sensory perception of taste#GO:0050912;nervous system process#GO:0050877;sensory perception#GO:0007600;detection of chemical stimulus involved in sensory perception of bitter taste#GO:0001580;system process#GO:0003008;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;detection of chemical stimulus#GO:0009593;sensory perception of bitter taste#GO:0050913;multicellular organismal process#GO:0032501;response to chemical#GO:0042221;response to stimulus#GO:0050896 membrane#GO:0016020;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=3544|UniProtKB=P08709 P08709 F7 PTHR24278:SF26 COAGULATION FACTOR COAGULATION FACTOR VII catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171 response to stimulus#GO:0050896;regulation of body fluid levels#GO:0050878;primary metabolic process#GO:0044238;hemostasis#GO:0007599;wound healing#GO:0042060;regulation of biological quality#GO:0065008;protein metabolic process#GO:0019538;proteolysis#GO:0006508;biological regulation#GO:0065007;biosynthetic process#GO:0009058;protein maturation#GO:0051604;multicellular organismal process#GO:0032501;gene expression#GO:0010467;coagulation#GO:0050817;cellular process#GO:0009987;protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059;response to stress#GO:0006950;response to wounding#GO:0009611;blood coagulation#GO:0007596;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 serine protease#PC00203 Blood coagulation#P00011>FVII#P00454;Angiogenesis#P00005>FVIIa#P00201;Blood coagulation#P00011>FVIIa#P00447 HUMAN|HGNC=11474|UniProtKB=Q15526 Q15526 SURF1 PTHR23427:SF15 SURFEIT LOCUS PROTEIN SURFEIT LOCUS PROTEIN 1 cellular component assembly#GO:0022607;mitochondrion organization#GO:0007005;mitochondrial respiratory chain complex assembly#GO:0033108;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;respiratory chain complex IV assembly#GO:0008535;protein-containing complex organization#GO:0043933;mitochondrial respiratory chain complex IV assembly#GO:0033617;cytochrome complex assembly#GO:0017004 mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 chaperone#PC00072 HUMAN|HGNC=9681|UniProtKB=Q13332 Q13332 PTPRS PTHR19134:SF542 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE S hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725;phosphoprotein phosphatase activity#GO:0004721;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788 synapse organization#GO:0050808;cell adhesion#GO:0007155;cell communication#GO:0007154;synaptic membrane adhesion#GO:0099560;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell junction organization#GO:0034330;signaling#GO:0023052;cellular component organization or biogenesis#GO:0071840;cell-cell adhesion#GO:0098609;signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HUMAN|HGNC=30598|UniProtKB=Q9NRH2 Q9NRH2 SNRK PTHR24343:SF181 SERINE/THREONINE KINASE SNF-RELATED SERINE_THREONINE-PROTEIN KINASE protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=3373|UniProtKB=Q09472 Q09472 EP300 PTHR13808:SF29 CBP/P300-RELATED HISTONE ACETYLTRANSFERASE P300 protein N-acetyltransferase activity#GO:0034212;transcription coactivator activity#GO:0003713;transferase activity#GO:0016740;protein N-acyltransferase activity#GO:0140186;histone modifying activity#GO:0140993;acetyltransferase activity#GO:0016407;binding#GO:0005488;transcription regulator activity#GO:0140110;catalytic activity, acting on a protein#GO:0140096;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity#GO:0003824;transcription coregulator activity#GO:0003712;chromatin DNA binding#GO:0031490;DNA binding#GO:0003677;histone acetyltransferase activity#GO:0004402;nucleic acid binding#GO:0003676;protein-lysine-acetyltransferase activity#GO:0061733;acyltransferase activity#GO:0016746;chromatin binding#GO:0003682;N-acetyltransferase activity#GO:0008080 regulation of RNA metabolic process#GO:0051252;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;positive regulation of RNA metabolic process#GO:0051254;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893 catalytic complex#GO:1902494;intracellular organelle#GO:0043229;protein acetyltransferase complex#GO:0031248;acetyltransferase complex#GO:1902493;intracellular anatomical structure#GO:0005622;chromosome#GO:0005694;organelle#GO:0043226;cellular anatomical structure#GO:0110165;transferase complex#GO:1990234;transcription regulator complex#GO:0005667;histone acetyltransferase complex#GO:0000123;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;chromatin#GO:0000785;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991 histone modifying enzyme#PC00261 Wnt signaling pathway#P00057>CBP#P01448;Huntington disease#P00029>CBP#P00777;p53 pathway#P00059>P300#P04611;Gonadotropin-releasing hormone receptor pathway#P06664>p300#P06737;p53 pathway#P00059>CBP#P04623;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>CREB#P00713;TGF-beta signaling pathway#P00052>Co-activators corepressors#P01282;Transcription regulation by bZIP transcription factor#P00055>CBP/P300#P01387 HUMAN|HGNC=8473|UniProtKB=Q96RC9 Q96RC9 OR8B4 PTHR48018:SF14 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 8B4 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;signaling#GO:0023052;response to stimulus#GO:0050896;sensory perception of smell#GO:0007608;regulation of cellular process#GO:0050794;sensory perception#GO:0007600;nervous system process#GO:0050877;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=21696|UniProtKB=Q9Y3Q8 Q9Y3Q8 TSC22D4 PTHR47610:SF1 TSC22 DOMAIN FAMILY PROTEIN 4 TSC22 DOMAIN FAMILY PROTEIN 4 HUMAN|HGNC=37146|UniProtKB=A6NCK2 A6NCK2 TRIM43B PTHR24103:SF621 E3 UBIQUITIN-PROTEIN LIGASE TRIM TRIPARTITE MOTIF-CONTAINING PROTEIN 43B catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659 response to other organism#GO:0051707;biological regulation#GO:0065007;defense response to other organism#GO:0098542;immune response#GO:0006955;defense response to symbiont#GO:0140546;response to stress#GO:0006950;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;response to biotic stimulus#GO:0009607;defense response#GO:0006952;regulation of gene expression#GO:0010468;response to external stimulus#GO:0009605;innate immune response#GO:0045087;regulation of biosynthetic process#GO:0009889;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;immune system process#GO:0002376 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=14554|UniProtKB=Q8WXI8 Q8WXI8 CLEC4D PTHR22802:SF11 C-TYPE LECTIN SUPERFAMILY MEMBER C-TYPE LECTIN DOMAIN FAMILY 4 MEMBER D binding#GO:0005488;carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 immune system process#GO:0002376;response to external stimulus#GO:0009605;defense response#GO:0006952;innate immune response#GO:0045087;defense response to symbiont#GO:0140546;immune response#GO:0006955;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;defense response to fungus#GO:0050832;response to other organism#GO:0051707;response to stimulus#GO:0050896;defense response to other organism#GO:0098542 cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944 membrane traffic protein#PC00150 HUMAN|HGNC=28752|UniProtKB=Q86UD1 Q86UD1 OAF PTHR13423:SF2 OUT AT FIRST OUT AT FIRST PROTEIN HOMOLOG HUMAN|HGNC=28430|UniProtKB=Q9BV81 Q9BV81 EMC6 PTHR20994:SF0 ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6 ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6 molecular carrier activity#GO:0140104;membrane insertase activity#GO:0032977;protein carrier activity#GO:0140597 metabolic process#GO:0008152;autophagosome assembly#GO:0000045;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;autophagosome organization#GO:1905037;autophagy#GO:0006914;establishment of protein localization#GO:0045184;establishment of protein localization to membrane#GO:0090150;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;macromolecule localization#GO:0033036;macroautophagy#GO:0016236;membrane organization#GO:0061024;endomembrane system organization#GO:0010256;tail-anchored membrane protein insertion into ER membrane#GO:0071816;protein insertion into membrane#GO:0051205;cellular component assembly#GO:0022607;localization within membrane#GO:0051668;organelle assembly#GO:0070925;process utilizing autophagic mechanism#GO:0061919;vacuole organization#GO:0007033;cellular localization#GO:0051641;localization#GO:0051179;endoplasmic reticulum organization#GO:0007029;protein insertion into ER membrane#GO:0045048;cellular component organization#GO:0016043;protein localization to organelle#GO:0033365;catabolic process#GO:0009056 membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;EMC complex#GO:0072546;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;endoplasmic reticulum protein-containing complex#GO:0140534;organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasm#GO:0005737;membrane#GO:0016020 HUMAN|HGNC=5661|UniProtKB=A0A0J9YXX1 A0A0J9YXX1 IGHV5-10-1 PTHR23266:SF348 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 5-10-1-RELATED binding#GO:0005488;antigen binding#GO:0003823 immune effector process#GO:0002252;immune system process#GO:0002376;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;immune response#GO:0006955;adaptive immune response#GO:0002250;response to stimulus#GO:0050896 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=13655|UniProtKB=Q8IX30 Q8IX30 SCUBE3 PTHR24046:SF2 SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 3 cellular response to growth factor stimulus#GO:0071363;smoothened signaling pathway#GO:0007224;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;cell communication#GO:0007154;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;signaling#GO:0023052;regulation of cellular process#GO:0050794;muscle structure development#GO:0061061;cell differentiation#GO:0030154;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;response to growth factor#GO:0070848;BMP signaling pathway#GO:0030509;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;muscle cell differentiation#GO:0042692;muscle cell development#GO:0055001;response to endogenous stimulus#GO:0009719;cellular developmental process#GO:0048869;cell surface receptor signaling pathway#GO:0007166;cellular response to BMP stimulus#GO:0071773;developmental process#GO:0032502;response to BMP#GO:0071772;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;biological regulation#GO:0065007;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;cellular process#GO:0009987;signal transduction#GO:0007165 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;extracellular region#GO:0005576;membrane#GO:0016020 extracellular matrix glycoprotein#PC00100 HUMAN|HGNC=4563|UniProtKB=O75791 O75791 GRAP2 PTHR46037:SF3 PROTEIN ENHANCER OF SEVENLESS 2B GRB2-RELATED ADAPTER PROTEIN 2 signaling receptor binding#GO:0005102;binding#GO:0005488;growth factor receptor binding#GO:0070851;protein binding#GO:0005515 cell communication#GO:0007154;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;regulation of MAPK cascade#GO:0043408;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of cell communication#GO:0010646;biological regulation#GO:0065007;signaling#GO:0023052;regulation of signal transduction#GO:0009966;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165 nuclear protein-containing complex#GO:0140513;cytoplasm#GO:0005737;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cell periphery#GO:0071944;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;COP9 signalosome#GO:0008180;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;organelle lumen#GO:0043233 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Grb#P00848;PDGF signaling pathway#P00047>Grb2#P01148;T cell activation#P00053>Gads#P01327 HUMAN|HGNC=13632|UniProtKB=Q92585 Q92585 MAML1 PTHR15692:SF19 MASTERMIND-LIKE MASTERMIND-LIKE PROTEIN 1 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription coactivator activity#GO:0003713 positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;signaling#GO:0023052;positive regulation of transcription by RNA polymerase II#GO:0045944;cell surface receptor signaling pathway#GO:0007166;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biosynthetic process#GO:0009891;cell communication#GO:0007154;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;cellular response to stimulus#GO:0051716;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;regulation of biosynthetic process#GO:0009889;Notch signaling pathway#GO:0007219;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of cellular process#GO:0048522;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233 transcription cofactor#PC00217;gene-specific transcriptional regulator#PC00264 Notch signaling pathway#P00045>Mastermind#P01106 HUMAN|HGNC=30167|UniProtKB=P13667 P13667 PDIA4 PTHR18929:SF210 PROTEIN DISULFIDE ISOMERASE PROTEIN DISULFIDE-ISOMERASE A4 isomerase activity#GO:0016853;catalytic activity, acting on a protein#GO:0140096;intramolecular oxidoreductase activity#GO:0016860;protein disulfide isomerase activity#GO:0003756;catalytic activity#GO:0003824 response to stress#GO:0006950;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;response to stimulus#GO:0050896;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;protein folding#GO:0006457;metabolic process#GO:0008152;response to endoplasmic reticulum stress#GO:0034976;cellular response to stress#GO:0033554;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cell surface#GO:0009986;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 chaperone#PC00072 HUMAN|HGNC=18019|UniProtKB=Q9H8U3 Q9H8U3 ZFAND3 PTHR10634:SF67 AN1-TYPE ZINC FINGER PROTEIN AN1-TYPE ZINC FINGER PROTEIN 3 HUMAN|HGNC=12491|UniProtKB=P61081 P61081 UBE2M PTHR24068:SF572 UBIQUITIN-CONJUGATING ENZYME E2 NEDD8-CONJUGATING ENZYME UBC12 catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;ubiquitin conjugating enzyme activity#GO:0061631;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-like protein conjugating enzyme activity#GO:0061650;ubiquitin-protein transferase activity#GO:0004842 protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;cellular process#GO:0009987;protein modification process#GO:0036211;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=24881|UniProtKB=Q0VAM2 Q0VAM2 RASGEF1B PTHR23113:SF197 GUANINE NUCLEOTIDE EXCHANGE FACTOR RAS-GEF DOMAIN-CONTAINING FAMILY MEMBER 1B molecular function regulator activity#GO:0098772;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;guanyl-nucleotide exchange factor activity#GO:0005085 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;intracellular signaling cassette#GO:0141124;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;Ras protein signal transduction#GO:0007265 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=32376|UniProtKB=Q0D2H9 Q0D2H9 GOLGA8DP PTHR10881:SF7 GOLGIN SUBFAMILY A MEMBER-RELATED GOLGIN SUBFAMILY A CONSERVED DOMAIN-CONTAINING PROTEIN-RELATED cellular process#GO:0009987;Golgi organization#GO:0007030;cellular component organization#GO:0016043;organelle organization#GO:0006996;endomembrane system organization#GO:0010256;cellular component organization or biogenesis#GO:0071840 Golgi stack#GO:0005795;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;Golgi cis cisterna#GO:0000137;cytoplasm#GO:0005737;Golgi cisterna#GO:0031985;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;cis-Golgi network#GO:0005801;organelle membrane#GO:0031090 membrane traffic protein#PC00150 HUMAN|HGNC=32204|UniProtKB=P0CG33 P0CG33 GOLGA6D PTHR10881:SF44 GOLGIN SUBFAMILY A MEMBER-RELATED GOLGIN SUBFAMILY A MEMBER 6A-RELATED endomembrane system organization#GO:0010256;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;Golgi organization#GO:0007030;cellular component organization#GO:0016043;organelle organization#GO:0006996 Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;Golgi cisterna#GO:0031985;endomembrane system#GO:0012505;Golgi cis cisterna#GO:0000137;cytoplasm#GO:0005737;Golgi apparatus#GO:0005794;cis-Golgi network#GO:0005801;organelle membrane#GO:0031090;Golgi stack#GO:0005795;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622 membrane traffic protein#PC00150 HUMAN|HGNC=8923|UniProtKB=O43175 O43175 PHGDH PTHR42938:SF22 FORMATE DEHYDROGENASE 1 D-3-PHOSPHOGLYCERATE DEHYDROGENASE oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 oxidoreductase#PC00176;dehydrogenase#PC00092 Serine glycine biosynthesis#P02776>Phosphoglycerate dehydrogenase#P03160 HUMAN|HGNC=6831|UniProtKB=O00462 O00462 MANBA PTHR43730:SF1 BETA-MANNOSIDASE BETA-MANNOSIDASE hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787 protein catabolic process#GO:0030163;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;primary metabolic process#GO:0044238;carbohydrate derivative catabolic process#GO:1901136;catabolic process#GO:0009056 protein modifying enzyme#PC00260 HUMAN|HGNC=55173|UniProtKB=P0DX04 P0DX04 TMSB15C PTHR12021:SF11 THYMOSIN BETA THYMOSIN BETA-15A-RELATED protein binding#GO:0005515;actin monomer binding#GO:0003785;protein sequestering activity#GO:0140311;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;binding#GO:0005488;molecular sequestering activity#GO:0140313 regulation of cell motility#GO:2000145;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;regulation of biological process#GO:0050789;regulation of cell migration#GO:0030334 supramolecular complex#GO:0099080;organelle#GO:0043226;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;actin cytoskeleton#GO:0015629;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;actin filament#GO:0005884 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=16485|UniProtKB=Q8NHY5 Q8NHY5 HUS1B PTHR12900:SF3 MITOTIC AND DNA DAMAGE CHECKPOINT PROTEIN HUS1 CHECKPOINT PROTEIN HUS1B regulation of cell cycle#GO:0051726;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;signal transduction in response to DNA damage#GO:0042770;double-strand break repair via homologous recombination#GO:0000724;cell cycle process#GO:0022402;negative regulation of biological process#GO:0048519;negative regulation of cell cycle phase transition#GO:1901988;mitotic intra-S DNA damage checkpoint signaling#GO:0031573;negative regulation of mitotic cell cycle phase transition#GO:1901991;signal transduction#GO:0007165;cellular process#GO:0009987;organelle organization#GO:0006996;negative regulation of cell cycle G2/M phase transition#GO:1902750;cellular component organization or biogenesis#GO:0071840;meiotic cell cycle#GO:0051321;DNA metabolic process#GO:0006259;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;cell cycle#GO:0007049;regulation of cell cycle phase transition#GO:1901987;primary metabolic process#GO:0044238;telomere organization#GO:0032200;regulation of G2/M transition of mitotic cell cycle#GO:0010389;sexual reproduction#GO:0019953;biological regulation#GO:0065007;mitotic cell cycle process#GO:1903047;chromosome organization#GO:0051276;macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;negative regulation of cellular process#GO:0048523;signaling#GO:0023052;mitotic DNA replication checkpoint signaling#GO:0033314;meiotic cell cycle process#GO:1903046;cellular component organization#GO:0016043;negative regulation of mitotic cell cycle#GO:0045930;regulation of mitotic cell cycle phase transition#GO:1901990;cellular response to stress#GO:0033554;regulation of cell cycle process#GO:0010564;cell cycle checkpoint signaling#GO:0000075;negative regulation of G2/M transition of mitotic cell cycle#GO:0010972;response to stress#GO:0006950;DNA replication checkpoint signaling#GO:0000076;double-strand break repair#GO:0006302;negative regulation of cell cycle#GO:0045786;DNA recombination#GO:0006310;metabolic process#GO:0008152;reproductive process#GO:0022414;mitotic cell cycle#GO:0000278;mitotic DNA damage checkpoint signaling#GO:0044773;mitotic cell cycle checkpoint signaling#GO:0007093;nucleic acid metabolic process#GO:0090304;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;recombinational repair#GO:0000725;nucleobase-containing compound metabolic process#GO:0006139;DNA damage checkpoint signaling#GO:0000077;mitotic G2/M transition checkpoint#GO:0044818;mitotic DNA integrity checkpoint signaling#GO:0044774;regulation of mitotic cell cycle#GO:0007346;regulation of cell cycle G2/M phase transition#GO:1902749;DNA integrity checkpoint signaling#GO:0031570;telomere maintenance#GO:0000723;negative regulation of cell cycle process#GO:0010948;DNA repair#GO:0006281 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;site of DNA damage#GO:0090734;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;chromosome#GO:0005694;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;condensed nuclear chromosome#GO:0000794;condensed chromosome#GO:0000793;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;site of double-strand break#GO:0035861;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 DNA metabolism protein#PC00009 HUMAN|HGNC=16364|UniProtKB=O15522 O15522 NKX2-8 PTHR24340:SF27 HOMEOBOX PROTEIN NKX HOMEOBOX PROTEIN NKX-2.8 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;developmental process#GO:0032502;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=16073|UniProtKB=Q8TD22 Q8TD22 SFXN5 PTHR11153:SF17 SIDEROFLEXIN SIDEROFLEXIN-5 citrate transmembrane transporter activity#GO:0015137;carboxylic acid transmembrane transporter activity#GO:0046943;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 mitochondrial transport#GO:0006839;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;cellular localization#GO:0051641;citrate transport#GO:0015746;intracellular transport#GO:0046907;tricarboxylic acid transport#GO:0006842;mitochondrial transmembrane transport#GO:1990542;organic acid transport#GO:0015849;transport#GO:0006810;carboxylic acid transport#GO:0046942 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;organelle envelope#GO:0031967;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 primary active transporter#PC00068 HUMAN|HGNC=25562|UniProtKB=Q3KR16 Q3KR16 PLEKHG6 PTHR47671:SF1 PLECKSTRIN DOMAIN-CONTAINING FAMILY G MEMBER 6 PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 6 HUMAN|HGNC=14871|UniProtKB=Q96A00 Q96A00 PPP1R14A PTHR16188:SF4 PROTEIN PHOSPHATASE 1 INHIBITOR POTENTIATED BY PROTEIN KINASE C PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 14A molecular function inhibitor activity#GO:0140678;protein phosphatase regulator activity#GO:0019888;enzyme regulator activity#GO:0030234;protein serine/threonine phosphatase inhibitor activity#GO:0004865;phosphatase inhibitor activity#GO:0019212;molecular function regulator activity#GO:0098772;phosphatase regulator activity#GO:0019208;enzyme inhibitor activity#GO:0004857;protein phosphatase inhibitor activity#GO:0004864 phosphatase modulator#PC00184 HUMAN|HGNC=29980|UniProtKB=Q6PIV2 Q6PIV2 FOXR1 PTHR46789:SF1 FORKHEAD BOX PROTEIN R1 FORKHEAD BOX PROTEIN R1 DNA binding#GO:0003677;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;sequence-specific DNA binding#GO:0043565;binding#GO:0005488;nucleic acid binding#GO:0003676 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 winged helix/forkhead transcription factor#PC00246 HUMAN|HGNC=15310|UniProtKB=Q8N0Y5 Q8N0Y5 OR8I2 PTHR48018:SF73 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 8I2 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 regulation of cellular process#GO:0050794;sensory perception of smell#GO:0007608;response to stimulus#GO:0050896;signaling#GO:0023052;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;nervous system process#GO:0050877;sensory perception#GO:0007600;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=30911|UniProtKB=Q9Y4B6 Q9Y4B6 DCAF1 PTHR13129:SF6 VPRBP PROTEIN-RELATED DDB1- AND CUL4-ASSOCIATED FACTOR 1 histone kinase activity#GO:0035173;transferase activity#GO:0016740;nuclear receptor binding#GO:0016922;nuclear estrogen receptor binding#GO:0030331;kinase activity#GO:0016301;protein binding#GO:0005515;RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629;phosphotransferase activity, alcohol group as acceptor#GO:0016773;histone modifying activity#GO:0140993;protein kinase activity#GO:0004672;DNA-binding transcription factor binding#GO:0140297;protein serine/threonine kinase activity#GO:0004674;binding#GO:0005488;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transcription factor binding#GO:0008134;transferase activity, transferring phosphorus-containing groups#GO:0016772 membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle#GO:0043229;Cul4-RING E3 ubiquitin ligase complex#GO:0080008;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 HUMAN|HGNC=15232|UniProtKB=Q8NH57 Q8NH57 OR52P1 PTHR26450:SF83 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 52P1 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=15921|UniProtKB=Q9UKM9 Q9UKM9 RALY PTHR13968:SF6 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN RNA-BINDING PROTEIN RALY RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 RNA metabolism protein#PC00031 HUMAN|HGNC=29221|UniProtKB=Q86X10 Q86X10 RALGAPB PTHR21344:SF1 RAL GTPASE-ACTIVATING PROTEIN SUBUNIT BETA RAL GTPASE-ACTIVATING PROTEIN SUBUNIT BETA enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;intracellular signaling cassette#GO:0141124;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;signaling#GO:0023052;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 HUMAN|HGNC=6697|UniProtKB=O75197 O75197 LRP5 PTHR46513:SF16 VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5 developmental process#GO:0032502;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;nervous system development#GO:0007399;multicellular organism development#GO:0007275;multicellular organismal process#GO:0032501;anatomical structure development#GO:0048856 transmembrane signal receptor#PC00197 Alzheimer disease-presenilin pathway#P00004>LRP C-terminal fragment#P00112;Alzheimer disease-presenilin pathway#P00004>LRP N-terminal fragment#P00169;Alzheimer disease-presenilin pathway#P00004>LRP intracellular fragment#P00173;Alzheimer disease-presenilin pathway#P00004>LRP transmembrane fragment#P00152;Alzheimer disease-presenilin pathway#P00004>LRP#P00150;Wnt signaling pathway#P00057>LRP5/6#P01431 HUMAN|HGNC=8851|UniProtKB=O60683 O60683 PEX10 PTHR23350:SF0 PEROXISOME ASSEMBLY PROTEIN 10 PEROXISOME BIOGENESIS FACTOR 10 intracellular protein localization#GO:0008104;establishment of protein localization to organelle#GO:0072594;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;intracellular protein transmembrane transport#GO:0065002;protein transmembrane import into intracellular organelle#GO:0044743;transport#GO:0006810;protein transmembrane transport#GO:0071806;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule localization#GO:0033036;organelle organization#GO:0006996;protein transport#GO:0015031;peroxisomal transport#GO:0043574;localization#GO:0051179;cellular localization#GO:0051641;transmembrane transport#GO:0055085;peroxisome organization#GO:0007031;protein import into peroxisome matrix#GO:0016558;protein localization to organelle#GO:0033365;cellular component organization#GO:0016043 intracellular organelle#GO:0043229;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;peroxisome#GO:0005777;microbody#GO:0042579;peroxisomal membrane#GO:0005778;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 chaperone#PC00072 HUMAN|HGNC=5964|UniProtKB=Q13651 Q13651 IL10RA PTHR20859:SF90 INTERFERON/INTERLEUKIN RECEPTOR INTERLEUKIN-10 RECEPTOR SUBUNIT ALPHA molecular transducer activity#GO:0060089;immune receptor activity#GO:0140375;signaling receptor activity#GO:0038023;cytokine receptor activity#GO:0004896;transmembrane signaling receptor activity#GO:0004888 signaling#GO:0023052;biological regulation#GO:0065007;response to chemical#GO:0042221;response to stimulus#GO:0050896;response to cytokine#GO:0034097;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to peptide#GO:1901652;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;cytokine-mediated signaling pathway#GO:0019221 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 Interleukin signaling pathway#P00036>Receptor subunit alpha#P00992 HUMAN|HGNC=25196|UniProtKB=Q96CK0 Q96CK0 ZNF653 PTHR46179:SF9 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 653 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=30265|UniProtKB=Q6WKZ4 Q6WKZ4 RAB11FIP1 PTHR15746:SF22 RAB11-RELATED RAB11 FAMILY-INTERACTING PROTEIN 1 localization#GO:0051179;secretion#GO:0046903;establishment of localization#GO:0051234;secretion by cell#GO:0032940;exocytosis#GO:0006887;regulated exocytosis#GO:0045055;transport#GO:0006810;vesicle-mediated transport#GO:0016192;export from cell#GO:0140352;cellular process#GO:0009987 intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 small GTPase#PC00208 HUMAN|HGNC=12525|UniProtKB=O60701 O60701 UGDH PTHR11374:SF59 UDP-GLUCOSE DEHYDROGENASE/UDP-MANNAC DEHYDROGENASE UDP-GLUCOSE 6-DEHYDROGENASE aminoglycan metabolic process#GO:0006022;metabolic process#GO:0008152;carbohydrate derivative biosynthetic process#GO:1901137;glycosaminoglycan biosynthetic process#GO:0006024;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;aminoglycan biosynthetic process#GO:0006023;glycosaminoglycan metabolic process#GO:0030203;biosynthetic process#GO:0009058 oxidoreductase#PC00176;dehydrogenase#PC00092 HUMAN|HGNC=26721|UniProtKB=Q86TB9 Q86TB9 PATL1 PTHR21551:SF2 TOPOISOMERASE II-ASSOCIATED PROTEIN PAT1 PROTEIN PAT1 HOMOLOG 1 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 regulation of gene expression#GO:0010468;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;nucleobase-containing compound metabolic process#GO:0006139;regulation of translation#GO:0006417;nucleobase-containing compound catabolic process#GO:0034655;regulation of macromolecule biosynthetic process#GO:0010556;organelle assembly#GO:0070925;catabolic process#GO:0009056;positive regulation of mRNA catabolic process#GO:0061014;nucleic acid metabolic process#GO:0090304;metabolic process#GO:0008152;positive regulation of mRNA metabolic process#GO:1903313;cellular component assembly#GO:0022607;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of protein metabolic process#GO:0051246;positive regulation of metabolic process#GO:0009893;RNA metabolic process#GO:0016070;negative regulation of metabolic process#GO:0009892;regulation of mRNA stability#GO:0043488;regulation of mRNA catabolic process#GO:0061013;membraneless organelle assembly#GO:0140694;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;regulation of catabolic process#GO:0009894;macromolecule metabolic process#GO:0043170;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;positive regulation of catabolic process#GO:0009896;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;nucleic acid catabolic process#GO:0141188;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of RNA metabolic process#GO:0051252;RNA decapping#GO:0110154;regulation of RNA stability#GO:0043487;positive regulation of RNA metabolic process#GO:0051254;negative regulation of protein metabolic process#GO:0051248;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;P-body assembly#GO:0033962;primary metabolic process#GO:0044238;cellular component organization or biogenesis#GO:0071840;regulation of mRNA metabolic process#GO:1903311;mRNA destabilization#GO:0061157;macromolecule catabolic process#GO:0009057;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;mRNA catabolic process#GO:0006402;RNA destabilization#GO:0050779;regulation of biological quality#GO:0065008;negative regulation of translation#GO:0017148;RNA catabolic process#GO:0006401;mRNA metabolic process#GO:0016071;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;P-body#GO:0000932;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;organelle#GO:0043226;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HUMAN|HGNC=16232|UniProtKB=Q96KJ9 Q96KJ9 COX4I2 PTHR10707:SF11 CYTOCHROME C OXIDASE SUBUNIT IV CYTOCHROME C OXIDASE SUBUNIT 4 ISOFORM 2, MITOCHONDRIAL generation of precursor metabolites and energy#GO:0006091;metabolic process#GO:0008152;aerobic electron transport chain#GO:0019646;mitochondrial electron transport, cytochrome c to oxygen#GO:0006123;aerobic respiration#GO:0009060;ATP synthesis coupled electron transport#GO:0042773;oxidative phosphorylation#GO:0006119;energy derivation by oxidation of organic compounds#GO:0015980;cellular respiration#GO:0045333;mitochondrial ATP synthesis coupled electron transport#GO:0042775;respiratory electron transport chain#GO:0022904;cellular process#GO:0009987;electron transport chain#GO:0022900 respiratory chain complex IV#GO:0045277;transmembrane transporter complex#GO:1902495;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;membrane protein complex#GO:0098796;mitochondrion#GO:0005739;cytochrome complex#GO:0070069;transporter complex#GO:1990351;organelle membrane#GO:0031090;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;membrane#GO:0016020;oxidoreductase complex#GO:1990204;mitochondrial inner membrane#GO:0005743;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrial membrane#GO:0031966;respiratory chain complex#GO:0098803 oxidoreductase#PC00176;oxidase#PC00175 HUMAN|HGNC=24643|UniProtKB=P58062 P58062 SPINK7 PTHR47499:SF1 SERINE PROTEASE INHIBITOR KAZAL-TYPE 7 SPINK7 SERINE PROTEASE INHIBITOR KAZAL-TYPE 7 endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772;enzyme inhibitor activity#GO:0004857;enzyme regulator activity#GO:0030234;serine-type endopeptidase inhibitor activity#GO:0004867;molecular function inhibitor activity#GO:0140678;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;peptidase regulator activity#GO:0061134 regulation of proteolysis#GO:0030162;negative regulation of cellular process#GO:0048523;defense response#GO:0006952;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;response to stress#GO:0006950;biological regulation#GO:0065007;inflammatory response#GO:0006954;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protein-binding activity modulator#PC00095;protease inhibitor#PC00191 HUMAN|HGNC=4481|UniProtKB=Q8NDV2 Q8NDV2 GPR26 PTHR24245:SF6 G-PROTEIN COUPLED RECEPTOR G PROTEIN-COUPLED RECEPTOR 26 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089 G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=28321|UniProtKB=Q5VYY1 Q5VYY1 ANKRD22 PTHR47276:SF1 ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 22 ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 22 response to stress#GO:0006950;response to wounding#GO:0009611;immune response#GO:0006955;cellular process#GO:0009987;response to stimulus#GO:0050896;cell migration#GO:0016477;cell motility#GO:0048870;leukocyte migration#GO:0050900;immune system process#GO:0002376 HUMAN|HGNC=10864|UniProtKB=Q11206 Q11206 ST3GAL4 PTHR13713:SF57 SIALYLTRANSFERASE CMP-N-ACETYLNEURAMINATE-BETA-GALACTOSAMIDE-ALPHA-2,3-SIALYLTRANSFERASE 4 transferase activity#GO:0016740;catalytic activity#GO:0003824;glycosyltransferase activity#GO:0016757;sialyltransferase activity#GO:0008373 liposaccharide metabolic process#GO:1903509;glycolipid metabolic process#GO:0006664;primary metabolic process#GO:0044238;glycolipid biosynthetic process#GO:0009247;protein metabolic process#GO:0019538;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058;glycoprotein biosynthetic process#GO:0009101;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;lipid metabolic process#GO:0006629 metabolite interconversion enzyme#PC00262;transferase#PC00220 HUMAN|HGNC=25139|UniProtKB=Q86YJ5 Q86YJ5 MARCHF9 PTHR46053:SF4 E3 UBIQUITIN-PROTEIN LIGASE MARCH4-LIKE E3 UBIQUITIN-PROTEIN LIGASE MARCHF9 aminoacyltransferase activity#GO:0016755;ubiquitin-protein transferase activity#GO:0004842;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824 Golgi stack#GO:0005795;Golgi apparatus subcompartment#GO:0098791;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;trans-Golgi network#GO:0005802;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=28833|UniProtKB=Q9NTK5 Q9NTK5 OLA1 PTHR23305:SF11 OBG GTPASE FAMILY OBG-LIKE ATPASE 1 pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP-dependent activity#GO:0140657;hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 G-protein#PC00020 HUMAN|HGNC=8875|UniProtKB=Q16877 Q16877 PFKFB4 PTHR10606:SF14 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE 6-PHOSPHOFRUCTO-2-KINASE_FRUCTOSE-2,6-BISPHOSPHATASE 4 sugar-phosphatase activity#GO:0050308;hydrolase activity#GO:0016787;phosphotransferase activity, alcohol group as acceptor#GO:0016773;carbohydrate kinase activity#GO:0019200;catalytic activity#GO:0003824;transferase activity#GO:0016740;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphoric ester hydrolase activity#GO:0042578 metabolic process#GO:0008152;organophosphate metabolic process#GO:0019637;phosphorus metabolic process#GO:0006793;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 phosphatase#PC00181;carbohydrate phosphatase#PC00066;hydrolase#PC00121 HUMAN|HGNC=17898|UniProtKB=Q9NYR9 Q9NYR9 NKIRAS2 PTHR46152:SF2 NF-KAPPA-B INHIBITOR-INTERACTING RAS-LIKE PROTEIN NF-KAPPA-B INHIBITOR-INTERACTING RAS-LIKE PROTEIN 2 protein binding#GO:0005515;binding#GO:0005488 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;signaling#GO:0023052;small GTPase-mediated signal transduction#GO:0007264 HUMAN|HGNC=28740|UniProtKB=Q8IXQ8 Q8IXQ8 PDZD9 PTHR22698:SF1 PDZ DOMAIN-CONTAINING PROTEIN 9 PDZ DOMAIN-CONTAINING PROTEIN 9 HUMAN|HGNC=28858|UniProtKB=Q9NXG6 Q9NXG6 P4HTM PTHR10869:SF249 PROLYL 4-HYDROXYLASE ALPHA SUBUNIT TRANSMEMBRANE PROLYL 4-HYDROXYLASE regulation of biological process#GO:0050789;regulation of cell development#GO:0060284;regulation of multicellular organismal development#GO:2000026;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;biological regulation#GO:0065007;regulation of developmental process#GO:0050793;regulation of multicellular organismal process#GO:0051239;regulation of myeloid cell differentiation#GO:0045637;regulation of cell differentiation#GO:0045595;regulation of hemopoiesis#GO:1903706 protein modifying enzyme#PC00260 HUMAN|HGNC=6986|UniProtKB=Q16626 Q16626 MEA1 PTHR17005:SF3 MALE-ENHANCED ANTIGEN-1 MALE-ENHANCED ANTIGEN 1 HUMAN|HGNC=16761|UniProtKB=Q86WZ0 Q86WZ0 HEATR4 PTHR12697:SF20 PBS LYASE HEAT-LIKE PROTEIN HEAT REPEAT-CONTAINING PROTEIN 4 catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 lyase#PC00144 HUMAN|HGNC=1130|UniProtKB=P62324 P62324 BTG1 PTHR22978:SF30 B-CELL TRANSLOCATION GENE PROTEIN BTG1 regulation of biological process#GO:0050789;negative regulation of cell population proliferation#GO:0008285;negative regulation of cellular process#GO:0048523;negative regulation of biological process#GO:0048519;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of cell population proliferation#GO:0042127 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=17928|UniProtKB=Q9P2W1 Q9P2W1 PSMC3IP PTHR15938:SF0 TBP-1 INTERACTING PROTEIN HOMOLOGOUS-PAIRING PROTEIN 2 HOMOLOG nucleic acid binding#GO:0003676;binding#GO:0005488;DNA binding#GO:0003677;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;double-stranded DNA binding#GO:0003690;enzyme activator activity#GO:0008047;molecular function regulator activity#GO:0098772 nucleobase-containing compound metabolic process#GO:0006139;chromosome organization#GO:0051276;meiotic chromosome segregation#GO:0045132;macromolecule metabolic process#GO:0043170;meiotic nuclear division#GO:0140013;homologous recombination#GO:0035825;reproductive process#GO:0022414;reciprocal homologous recombination#GO:0140527;cell cycle#GO:0007049;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;organelle fission#GO:0048285;sexual reproduction#GO:0019953;meiosis I cell cycle process#GO:0061982;homologous chromosome pairing at meiosis#GO:0007129;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization or biogenesis#GO:0071840;homologous chromosome segregation#GO:0045143;DNA recombination#GO:0006310;chromosome segregation#GO:0007059;meiotic cell cycle#GO:0051321;chromosome organization involved in meiotic cell cycle#GO:0070192;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;cell cycle process#GO:0022402;cellular component organization#GO:0016043;meiosis I#GO:0007127;nuclear chromosome segregation#GO:0098813;meiotic cell cycle process#GO:1903046;reciprocal meiotic recombination#GO:0007131;nuclear division#GO:0000280 condensed nuclear chromosome#GO:0000794;membraneless organelle#GO:0043228;condensed chromosome#GO:0000793;protein-containing complex#GO:0032991;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;organelle lumen#GO:0043233 DNA metabolism protein#PC00009 General transcription by RNA polymerase I#P00022>TBP#P00657;Transcription regulation by bZIP transcription factor#P00055>TBP#P01399;General transcription regulation#P00023>TBP#P00670;General transcription by RNA polymerase I#P00022>SL1 complex#P00653 HUMAN|HGNC=6182|UniProtKB=Q14573 Q14573 ITPR3 PTHR13715:SF51 RYANODINE RECEPTOR AND IP3 RECEPTOR INOSITOL 1,4,5-TRISPHOSPHATE-GATED CALCIUM CHANNEL ITPR3 channel activity#GO:0015267;cation binding#GO:0043169;anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation channel activity#GO:0005261;phosphatidylinositol binding#GO:0035091;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;ligand-gated monoatomic cation channel activity#GO:0099094;calcium channel activity#GO:0005262;transmembrane transporter activity#GO:0022857;metal ion binding#GO:0046872;monoatomic cation transmembrane transporter activity#GO:0008324;ligand-gated calcium channel activity#GO:0099604;calcium ion transmembrane transporter activity#GO:0015085;binding#GO:0005488;gated channel activity#GO:0022836;calcium ion binding#GO:0005509;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873;alcohol binding#GO:0043178;transporter activity#GO:0005215 transport#GO:0006810;establishment of localization#GO:0051234;calcium ion transmembrane import into cytosol#GO:0097553;calcium ion transport#GO:0006816;signal transduction#GO:0007165;release of sequestered calcium ion into cytosol#GO:0051209;cellular process#GO:0009987;biological regulation#GO:0065007;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;G protein-coupled receptor signaling pathway#GO:0007186;phospholipase C-activating G protein-coupled receptor signaling pathway#GO:0007200;localization#GO:0051179;cell communication#GO:0007154;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;calcium ion transmembrane transport#GO:0070588;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;metal ion transport#GO:0030001;signaling#GO:0023052 bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;plasma membrane#GO:0005886;cytoplasm#GO:0005737;vesicle membrane#GO:0012506;secretory vesicle#GO:0099503;membrane#GO:0016020;sarcoplasmic reticulum#GO:0016529;cell periphery#GO:0071944;organelle subcompartment#GO:0031984;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;sarcoplasm#GO:0016528;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;secretory granule membrane#GO:0030667;intracellular vesicle#GO:0097708;vesicle#GO:0031982 ligand-gated ion channel#PC00141;ion channel#PC00133 B cell activation#P00010>IP3R#P00398;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>IP3 channel#P00735;Gonadotropin-releasing hormone receptor pathway#P06664>IP3R#P06768;PDGF signaling pathway#P00047>IP3 receptor#P01160;Histamine H1 receptor mediated signaling pathway#P04385>IP3R#P04486;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>IP3R#P00842;Endothelin signaling pathway#P00019>IP3 R#P00590;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>IP3R#P01064;Angiotensin II-stimulated signaling through G proteins and beta-arrestin#P05911>IP3R#P05932;Wnt signaling pathway#P00057>IP3 Gated Calcium Channel#P01426 HUMAN|HGNC=17002|UniProtKB=Q8N2W9 Q8N2W9 PIAS4 PTHR10782:SF9 ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN E3 SUMO-PROTEIN LIGASE PIAS4 catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;molecular function regulator activity#GO:0098772;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;SUMO transferase activity#GO:0019789;SUMO ligase activity#GO:0061665;acyltransferase activity#GO:0016746;molecular function inhibitor activity#GO:0140678;ubiquitin-like protein ligase activity#GO:0061659 cellular process#GO:0009987;negative regulation of signal transduction#GO:0009968;metabolic process#GO:0008152;protein sumoylation#GO:0016925;negative regulation of biological process#GO:0048519;protein modification by small protein conjugation#GO:0032446;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of signaling#GO:0023057;protein modification by small protein conjugation or removal#GO:0070647;regulation of signaling#GO:0023051;negative regulation of cell communication#GO:0010648;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of response to stimulus#GO:0048585;regulation of nucleobase-containing compound metabolic process#GO:0019219;post-translational protein modification#GO:0043687;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of cellular process#GO:0048523;regulation of receptor signaling pathway via JAK-STAT#GO:0046425;regulation of response to stimulus#GO:0048583;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulation of gene expression#GO:0010468;primary metabolic process#GO:0044238;protein modification process#GO:0036211;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of cell communication#GO:0010646;regulation of receptor signaling pathway via STAT#GO:1904892;regulation of DNA-templated transcription#GO:0006355;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;regulation of RNA metabolic process#GO:0051252 nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;chromatin#GO:0000785;membraneless organelle#GO:0043228 ubiquitin-protein ligase#PC00234 Interferon-gamma signaling pathway#P00035>PIAS#P00958;JAK/STAT signaling pathway#P00038>PIAS#P01031 HUMAN|HGNC=13799|UniProtKB=P30040 P30040 ERP29 PTHR12211:SF1 ENDOPLASMIC RETICULUM PROTEIN ERP29 ENDOPLASMIC RETICULUM RESIDENT PROTEIN 29 protein binding#GO:0005515;binding#GO:0005488;protein-folding chaperone binding#GO:0051087 protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;regulation of response to stress#GO:0080134;regulation of apoptotic process#GO:0042981;regulation of response to stimulus#GO:0048583;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;protein folding#GO:0006457;regulation of programmed cell death#GO:0043067;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;regulation of response to endoplasmic reticulum stress#GO:1905897;regulation of intrinsic apoptotic signaling pathway#GO:2001242;protein metabolic process#GO:0019538;regulation of cellular response to stress#GO:0080135;regulation of intracellular signal transduction#GO:1902531;regulation of apoptotic signaling pathway#GO:2001233;regulation of signaling#GO:0023051 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 membrane traffic protein#PC00150 HUMAN|HGNC=3081|UniProtKB=Q96PT4 Q96PT4 DUX3 PTHR46123:SF3 MIX-TYPE HOMEOBOX GENE 1-RELATED DOUBLE HOMEOBOX PROTEIN 1-RELATED sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=4913|UniProtKB=O00291 O00291 HIP1 PTHR10407:SF14 HUNTINGTIN INTERACTING PROTEIN 1 HUNTINGTIN-INTERACTING PROTEIN 1 cytoskeletal adaptor activity#GO:0008093;cytoskeletal protein binding#GO:0008092;phospholipid binding#GO:0005543;molecular adaptor activity#GO:0060090;phosphatidylinositol phosphate binding#GO:1901981;actin filament binding#GO:0051015;actin binding#GO:0003779;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;protein-containing complex binding#GO:0044877;protein-membrane adaptor activity#GO:0043495;lipid binding#GO:0008289;protein binding#GO:0005515 protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;import into cell#GO:0098657;regulation of apoptotic process#GO:0042981;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;endocytosis#GO:0006897;regulation of biological process#GO:0050789;protein-containing complex assembly#GO:0065003;regulation of programmed cell death#GO:0043067;cellular component organization#GO:0016043;actin filament organization#GO:0007015;establishment of localization#GO:0051234;transport#GO:0006810;regulation of response to stimulus#GO:0048583;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of epidermal growth factor receptor signaling pathway#GO:0042058;positive regulation of response to stimulus#GO:0048584;positive regulation of cellular process#GO:0048522;supramolecular fiber organization#GO:0097435;localization#GO:0051179;actin filament-based process#GO:0030029;regulation of cell communication#GO:0010646;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of ERBB signaling pathway#GO:1901184;positive regulation of signal transduction#GO:0009967 intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;coated vesicle#GO:0030135;membrane-bounded organelle#GO:0043227;cortical cytoskeleton#GO:0030863;actin cytoskeleton#GO:0015629;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cell cortex#GO:0005938;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoskeleton#GO:0005856;clathrin-coated vesicle#GO:0030136;membraneless organelle#GO:0043228;cell junction#GO:0030054;cell periphery#GO:0071944;presynapse#GO:0098793;cytoplasm#GO:0005737;cortical actin cytoskeleton#GO:0030864;intracellular membraneless organelle#GO:0043232 non-motor actin binding protein#PC00165;cytoskeletal protein#PC00085 Huntington disease#P00029>Hip-1#P00765 HUMAN|HGNC=4589|UniProtKB=Q7Z429 Q7Z429 GRINA PTHR23291:SF16 BAX INHIBITOR-RELATED PROTEIN LIFEGUARD 1 monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261;metal ion transmembrane transporter activity#GO:0046873;passive transmembrane transporter activity#GO:0022803;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;calcium ion transmembrane transporter activity#GO:0015085;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324 regulation of neuron apoptotic process#GO:0043523;response to stress#GO:0006950;negative regulation of neuron apoptotic process#GO:0043524;negative regulation of programmed cell death#GO:0043069;signal transduction#GO:0007165;cellular process#GO:0009987;negative regulation of signal transduction#GO:0009968;regulation of apoptotic process#GO:0042981;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;response to topologically incorrect protein#GO:0035966;signaling#GO:0023052;negative regulation of signaling#GO:0023057;cellular response to stress#GO:0033554;regulation of signaling#GO:0023051;response to unfolded protein#GO:0006986;negative regulation of cell communication#GO:0010648;endoplasmic reticulum unfolded protein response#GO:0030968;negative regulation of extrinsic apoptotic signaling pathway#GO:2001237;negative regulation of apoptotic process#GO:0043066;negative regulation of response to stimulus#GO:0048585;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of extrinsic apoptotic signaling pathway#GO:2001236;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;cellular response to unfolded protein#GO:0034620;response to endoplasmic reticulum stress#GO:0034976;negative regulation of apoptotic signaling pathway#GO:2001234;regulation of apoptotic signaling pathway#GO:2001233;cellular response to topologically incorrect protein#GO:0035967;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783 transporter#PC00227;ion channel#PC00133 Metabotropic glutamate receptor group I pathway#P00041>NMDA#P01060 HUMAN|HGNC=24060|UniProtKB=Q96C74 Q96C74 ROPN1L PTHR14952:SF14 ROPPORIN-1-LIKE PROTEIN ROPPORIN-1-LIKE PROTEIN developmental process involved in reproduction#GO:0003006;anatomical structure maturation#GO:0071695;germ cell development#GO:0007281;sperm motility#GO:0097722;cell differentiation#GO:0030154;cell motility#GO:0048870;gamete generation#GO:0007276;microtubule-based movement#GO:0007018;cellular process involved in reproduction in multicellular organism#GO:0022412;reproductive process#GO:0022414;cell development#GO:0048468;spermatid differentiation#GO:0048515;cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;sexual reproduction#GO:0019953;spermatid development#GO:0007286;cilium-dependent cell motility#GO:0060285;anatomical structure development#GO:0048856;multicellular organismal reproductive process#GO:0048609;cilium movement involved in cell motility#GO:0060294;cellular process#GO:0009987;developmental maturation#GO:0021700;male gamete generation#GO:0048232;sperm capacitation#GO:0048240;flagellated sperm motility#GO:0030317;spermatogenesis#GO:0007283;developmental process#GO:0032502;cell maturation#GO:0048469;cellular developmental process#GO:0048869;microtubule-based process#GO:0007017 cilium#GO:0005929;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;motile cilium#GO:0031514;organelle#GO:0043226 HUMAN|HGNC=1143|UniProtKB=Q6UXE8 Q6UXE8 BTNL3 PTHR24100:SF135 BUTYROPHILIN BUTYROPHILIN-LIKE PROTEIN 3 signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515 immune response-regulating signaling pathway#GO:0002764;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signaling#GO:0023052;immune system process#GO:0002376;positive regulation of immune system process#GO:0002684;cellular process#GO:0009987;activation of immune response#GO:0002253;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;antigen receptor-mediated signaling pathway#GO:0050851;regulation of multicellular organismal process#GO:0051239;cell surface receptor signaling pathway#GO:0007166;immune response-activating signaling pathway#GO:0002757;cellular response to stimulus#GO:0051716;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;immune response-activating cell surface receptor signaling pathway#GO:0002429;regulation of immune response#GO:0050776;cell communication#GO:0007154;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of cytokine production#GO:0001817;positive regulation of response to stimulus#GO:0048584;immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007;T cell receptor signaling pathway#GO:0050852;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 membrane#GO:0016020;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=775|UniProtKB=P01008 P01008 SERPINC1 PTHR11461:SF53 SERINE PROTEASE INHIBITOR, SERPIN ANTITHROMBIN-III cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 Blood coagulation#P00011>ATIII#P00440 HUMAN|HGNC=16268|UniProtKB=Q8IY17 Q8IY17 PNPLA6 PTHR14226:SF26 NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER PATATIN-LIKE PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN 6 carboxylic ester hydrolase activity#GO:0052689;phosphatidylcholine lysophospholipase A1 activity#GO:0004622;lipase activity#GO:0016298;hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phospholipase activity#GO:0120569;glycerophospholipase activity#GO:0004620;catalytic activity#GO:0003824 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 esterase#PC00097;hydrolase#PC00121 HUMAN|HGNC=8944|UniProtKB=Q9UIV8 Q9UIV8 SERPINB13 PTHR11461:SF161 SERINE PROTEASE INHIBITOR, SERPIN SERPIN B13 molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866;enzyme inhibitor activity#GO:0004857;serine-type endopeptidase inhibitor activity#GO:0004867;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;peptidase regulator activity#GO:0061134;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HUMAN|HGNC=20456|UniProtKB=Q6Q0C0 Q6Q0C0 TRAF7 PTHR19848:SF6 WD40 REPEAT PROTEIN E3 UBIQUITIN-PROTEIN LIGASE TRAF7 positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of response to stimulus#GO:0048584;regulation of ERK1 and ERK2 cascade#GO:0070372;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of MAPK cascade#GO:0043408;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;positive regulation of MAPK cascade#GO:0043410;positive regulation of signal transduction#GO:0009967;programmed cell death#GO:0012501;regulation of biological process#GO:0050789;apoptotic process#GO:0006915;cell death#GO:0008219;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;regulation of Notch signaling pathway#GO:0008593;positive regulation of signaling#GO:0023056 organelle lumen#GO:0043233;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ubiquitin ligase complex#GO:0000151;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;transferase complex#GO:1990234;membraneless organelle#GO:0043228;intracellular protein-containing complex#GO:0140535 HUMAN|HGNC=3773|UniProtKB=P49326 P49326 FMO5 PTHR23023:SF78 DIMETHYLANILINE MONOOXYGENASE FLAVIN-CONTAINING MONOOXYGENASE 5 oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen#GO:0016709;catalytic activity#GO:0003824;monooxygenase activity#GO:0004497;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705 oxygenase#PC00177;oxidoreductase#PC00176 HUMAN|HGNC=25794|UniProtKB=Q9H8W3 Q9H8W3 FAM204A PTHR14386:SF2 PROTEIN FAM204A PROTEIN FAM204A HUMAN|HGNC=26790|UniProtKB=Q3MJ13 Q3MJ13 WDR72 PTHR44099:SF2 RABCONNECTIN-3B, ISOFORM A WD REPEAT-CONTAINING PROTEIN 72 localization within membrane#GO:0051668;protein localization to cell periphery#GO:1990778;intracellular protein localization#GO:0008104;localization#GO:0051179;cellular localization#GO:0051641;cellular process#GO:0009987;protein localization to membrane#GO:0072657;macromolecule localization#GO:0033036;protein localization to plasma membrane#GO:0072659 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=9546|UniProtKB=P28065 P28065 PSMB9 PTHR11599:SF50 PROTEASOME SUBUNIT ALPHA/BETA PROTEASOME SUBUNIT BETA TYPE-9 catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233 cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 endopeptidase complex#GO:1905369;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;proteasome complex#GO:0000502;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;peptidase complex#GO:1905368;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 protease#PC00190;protein modifying enzyme#PC00260 HUMAN|HGNC=23386|UniProtKB=O75592 O75592 MYCBP2 PTHR45943:SF1 E3 UBIQUITIN-PROTEIN LIGASE MYCBP2 E3 UBIQUITIN-PROTEIN LIGASE MYCBP2 ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 regulation of biological quality#GO:0065008;axonogenesis#GO:0007409;neuron development#GO:0048666;regulation of synapse organization#GO:0050807;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;regulation of cellular component biogenesis#GO:0044087;cell development#GO:0048468;cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;cell differentiation#GO:0030154;regulation of cellular component organization#GO:0051128;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;cell projection morphogenesis#GO:0048858;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;cellular process#GO:0009987;neuron projection development#GO:0031175;system development#GO:0048731;anatomical structure development#GO:0048856;regulation of synapse structure or activity#GO:0050803;regulation of cell junction assembly#GO:1901888;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;regulation of growth#GO:0040008;neurogenesis#GO:0022008;neuron projection guidance#GO:0097485;cellular developmental process#GO:0048869;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regulation of synapse assembly#GO:0051963;axon development#GO:0061564;axon guidance#GO:0007411 nucleus#GO:0005634;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=25525|UniProtKB=Q9BTX1 Q9BTX1 NDC1 PTHR13269:SF6 NUCLEOPORIN NDC1 NUCLEOPORIN NDC1 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;nucleus organization#GO:0006997;nuclear pore organization#GO:0006999;protein-containing complex organization#GO:0043933 organelle envelope#GO:0031967;nucleus#GO:0005634;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear pore#GO:0005643 HUMAN|HGNC=1769|UniProtKB=O14735 O14735 CDIPT PTHR15362:SF4 PHOSPHATIDYLINOSITOL SYNTHASE CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, for other substituted phosphate groups#GO:0016780 organophosphate biosynthetic process#GO:0090407;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;glycerolipid metabolic process#GO:0046486;phospholipid biosynthetic process#GO:0008654;phospholipid metabolic process#GO:0006644;metabolic process#GO:0008152;glycerophospholipid biosynthetic process#GO:0046474;phosphatidylinositol metabolic process#GO:0046488;lipid metabolic process#GO:0006629;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;glycerophospholipid metabolic process#GO:0006650;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 transferase#PC00220 HUMAN|HGNC=11821|UniProtKB=P16035 P16035 TIMP2 PTHR11844:SF24 METALLOPROTEASE INHIBITOR METALLOPROTEINASE INHIBITOR 2 enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;peptidase regulator activity#GO:0061134;endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772;enzyme inhibitor activity#GO:0004857 negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;regulation of macromolecule metabolic process#GO:0060255;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;response to endogenous stimulus#GO:0009719;negative regulation of catabolic process#GO:0009895;response to peptide#GO:1901652;regulation of protein catabolic process#GO:0042176;biological regulation#GO:0065007;response to chemical#GO:0042221;response to cytokine#GO:0034097;negative regulation of protein catabolic process#GO:0042177;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;regulation of protein metabolic process#GO:0051246;response to hormone#GO:0009725;regulation of metabolic process#GO:0019222;regulation of catabolic process#GO:0009894;regulation of proteolysis#GO:0030162;negative regulation of cellular process#GO:0048523 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012 protease inhibitor#PC00191;protein-binding activity modulator#PC00095 HUMAN|HGNC=14998|UniProtKB=Q8NGX0 Q8NGX0 OR11L1 PTHR26452:SF701 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 11L1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 sensory perception of chemical stimulus#GO:0007606;sensory perception#GO:0007600;nervous system process#GO:0050877;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;system process#GO:0003008 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=6587|UniProtKB=Q86WI0 Q86WI0 LHFPL1 PTHR12489:SF15 LIPOMA HMGIC FUSION PARTNER-LIKE PROTEIN LHFPL TETRASPAN SUBFAMILY MEMBER 1 PROTEIN membrane#GO:0016020;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=25771|UniProtKB=Q9H974 Q9H974 QTRT2 PTHR46064:SF1 QUEUINE TRNA-RIBOSYLTRANSFERASE ACCESSORY SUBUNIT 2 QUEUINE TRNA-RIBOSYLTRANSFERASE ACCESSORY SUBUNIT 2 RNA metabolism protein#PC00031;RNA processing factor#PC00147 HUMAN|HGNC=14153|UniProtKB=A2IDD5 A2IDD5 CCDC78 PTHR22106:SF5 COILED-COIL DOMAIN-CONTAINING PROTEIN 78 COILED-COIL DOMAIN-CONTAINING PROTEIN 78 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=33855|UniProtKB=Q6RFH8 Q6RFH8 DUX4L9 PTHR46123:SF3 MIX-TYPE HOMEOBOX GENE 1-RELATED DOUBLE HOMEOBOX PROTEIN 1-RELATED RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=4261|UniProtKB=P01241 P01241 GH1 PTHR11417:SF2 SOMATOTROPIN,PROLACTIN SOMATOTROPIN protein binding#GO:0005515;hormone activity#GO:0005179;molecular function activator activity#GO:0140677;signaling receptor binding#GO:0005102;cytokine receptor binding#GO:0005126;binding#GO:0005488;hormone receptor binding#GO:0051427;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;growth factor activity#GO:0008083 cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;cellular response to peptide hormone stimulus#GO:0071375;regulation of receptor signaling pathway via STAT#GO:1904892;regulation of cell communication#GO:0010646;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of receptor signaling pathway via JAK-STAT#GO:0046427;response to nitrogen compound#GO:1901698;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;positive regulation of cellular process#GO:0048522;response to nutrient levels#GO:0031667;response to peptide hormone#GO:0043434;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;cellular response to nitrogen compound#GO:1901699;positive regulation of response to stimulus#GO:0048584;regulation of receptor signaling pathway via JAK-STAT#GO:0046425;regulation of response to stimulus#GO:0048583;developmental process#GO:0032502;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;signaling#GO:0023052;cellular response to hormone stimulus#GO:0032870;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;regulation of signaling#GO:0023051;response to oxygen-containing compound#GO:1901700;animal gross anatomical part developmental process#GO:0160108;cellular response to chemical stimulus#GO:0070887;positive regulation of signaling#GO:0023056;cellular process#GO:0009987;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;positive regulation of biological process#GO:0048518;response to hormone#GO:0009725;response to chemical#GO:0042221;cell surface receptor signaling pathway#GO:0007166;animal organ development#GO:0048513 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 peptide hormone#PC00179 HUMAN|HGNC=19316|UniProtKB=Q32P28 Q32P28 P3H1 PTHR14049:SF5 LEPRECAN 1 PROLYL 3-HYDROXYLASE 1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824;dioxygenase activity#GO:0051213;catalytic activity, acting on a protein#GO:0140096;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;oxidoreductase activity#GO:0016491 metabolic process#GO:0008152;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 extracellular matrix glycoprotein#PC00100 HUMAN|HGNC=4574|UniProtKB=P48058 P48058 GRIA4 PTHR18966:SF100 IONOTROPIC GLUTAMATE RECEPTOR GLUTAMATE RECEPTOR 4 dicarboxylic acid transmembrane transporter activity#GO:0005310;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;ligand-gated channel activity#GO:0022834;glutamate receptor activity#GO:0008066;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;molecular transducer activity#GO:0060089;channel activity#GO:0015267;carboxylic acid transmembrane transporter activity#GO:0046943;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic ion channel activity#GO:0005216;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion transmembrane transporter activity#GO:0015075;signaling receptor activity#GO:0038023;amino acid transmembrane transporter activity#GO:0015171;neurotransmitter receptor activity#GO:0030594;transporter activity#GO:0005215;gated channel activity#GO:0022836;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;trans-synaptic signaling#GO:0099537;regulation of signaling#GO:0023051;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;signaling#GO:0023052;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;regulation of trans-synaptic signaling#GO:0099177;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;synaptic transmission, glutamatergic#GO:0035249;synaptic signaling#GO:0099536;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;monoatomic ion channel complex#GO:0034702;neuron to neuron synapse#GO:0098984;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;signaling receptor complex#GO:0043235;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;asymmetric synapse#GO:0032279;plasma membrane bounded cell projection#GO:0120025;dendrite#GO:0030425;postsynaptic density#GO:0014069;dendritic tree#GO:0097447;transmembrane transporter complex#GO:1902495;postsynaptic density membrane#GO:0098839;neuron projection#GO:0043005;protein-containing complex#GO:0032991;synaptic membrane#GO:0097060;transporter complex#GO:1990351;cell junction#GO:0030054;postsynapse#GO:0098794;dendritic spine#GO:0043197;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;neuron spine#GO:0044309;cell projection#GO:0042995;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634 transmembrane signal receptor#PC00197 Ionotropic glutamate receptor pathway#P00037>Glu4#P01015;Ionotropic glutamate receptor pathway#P00037>A/K#P01025;Metabotropic glutamate receptor group III pathway#P00039>A/K#P01046;Ionotropic glutamate receptor pathway#P00037>AMPA#P01019 HUMAN|HGNC=7030|UniProtKB=Q9UBP6 Q9UBP6 METTL1 PTHR23417:SF24 3-DEOXY-D-MANNO-OCTULOSONIC-ACID TRANSFERASE/TRNA GUANINE-N 7 - -METHYLTRANSFERASE TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring one-carbon groups#GO:0016741;RNA methyltransferase activity#GO:0008173;catalytic activity, acting on RNA#GO:0140098;tRNA methyltransferase activity#GO:0008175;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;catalytic activity, acting on a tRNA#GO:0140101;tRNA (guanine) methyltransferase activity#GO:0016423 macromolecule methylation#GO:0043414;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;RNA methylation#GO:0001510;methylation#GO:0032259;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;tRNA modification#GO:0006400;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;tRNA methylation#GO:0030488;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058 methyltransferase complex#GO:0034708;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;transferase complex#GO:1990234 RNA processing factor#PC00147 HUMAN|HGNC=28698|UniProtKB=Q8TF46 Q8TF46 DIS3L PTHR23355:SF30 RIBONUCLEASE DIS3-LIKE EXONUCLEASE 1 3'-5'-RNA exonuclease activity#GO:0000175;exonuclease activity#GO:0004527;nuclease activity#GO:0004518;hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;RNA nuclease activity#GO:0004540;3'-5' exonuclease activity#GO:0008408;catalytic activity, acting on RNA#GO:0140098 nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;nucleobase-containing compound catabolic process#GO:0034655;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;nucleic acid catabolic process#GO:0141188;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulation of gene expression#GO:0010468;rRNA metabolic process#GO:0016072;macromolecule catabolic process#GO:0009057;negative regulation of cellular process#GO:0048523;metabolic process#GO:0008152;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;RNA metabolic process#GO:0016070;RNA catabolic process#GO:0006401 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494 exoribonuclease#PC00099 HUMAN|HGNC=1352|UniProtKB=P07357 P07357 C8A PTHR45742:SF1 COMPLEMENT COMPONENT C6 COMPLEMENT COMPONENT C8 ALPHA CHAIN immune system process#GO:0002376;regulation of immune response#GO:0050776;regulation of immune system process#GO:0002682;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;humoral immune response#GO:0006959;immune effector process#GO:0002252;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;positive regulation of immune system process#GO:0002684;activation of immune response#GO:0002253;complement activation#GO:0006956;immune response#GO:0006955;positive regulation of biological process#GO:0048518 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;extracellular region#GO:0005576 complement component#PC00078 HUMAN|HGNC=28965|UniProtKB=P42696 P42696 RBM34 PTHR23236:SF25 EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H RNA-BINDING PROTEIN 34 nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 translational protein#PC00263;translation initiation factor#PC00224;translation factor#PC00223 HUMAN|HGNC=30399|UniProtKB=P59797 P59797 SELENOV PTHR15124:SF17 SELENOPROTEIN W SELENOPROTEIN V intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 HUMAN|HGNC=26689|UniProtKB=Q6ZN01 Q6ZN01 MAMSTR PTHR23251:SF1 LYSINE-RICH CEACAM1 CO-ISOLATED PROTEIN LYRIC PROTEIN MEF2-ACTIVATING MOTIF AND SAP DOMAIN-CONTAINING TRANSCRIPTIONAL REGULATOR transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=19344|UniProtKB=Q6IQ26 Q6IQ26 DENND5A PTHR46070:SF2 PINSTRIPE, ISOFORM A DENN DOMAIN-CONTAINING PROTEIN 5A GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function regulator activity#GO:0098772;binding#GO:0005488;guanyl-nucleotide exchange factor activity#GO:0005085;enzyme binding#GO:0019899;small GTPase binding#GO:0031267;enzyme regulator activity#GO:0030234;protein binding#GO:0005515 intracellular transport#GO:0046907;transport#GO:0006810;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;endosomal transport#GO:0016197;retrograde transport, endosome to Golgi#GO:0042147;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;cytosolic transport#GO:0016482 membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;trans-Golgi network#GO:0005802;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;Golgi apparatus subcompartment#GO:0098791 HUMAN|HGNC=25145|UniProtKB=Q96G42 Q96G42 KLHDC7B PTHR45972:SF5 BTB_2 DOMAIN-CONTAINING PROTEIN KELCH DOMAIN-CONTAINING PROTEIN 7B HUMAN|HGNC=27741|UniProtKB=D6RIA3 D6RIA3 C4orf54 PTHR33775:SF4 CARDIAC-ENRICHED FHL2-INTERACTING PROTEIN-RELATED SIMILAR TO HUMAN CHROMOSOME 4 OPEN READING FRAME 54 HUMAN|HGNC=25451|UniProtKB=Q1KMD3 Q1KMD3 HNRNPUL2 PTHR12381:SF66 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN U FAMILY MEMBER HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN U-LIKE PROTEIN 2 nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;alternative mRNA splicing, via spliceosome#GO:0000380;macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=38650|UniProtKB=A6NMD2 A6NMD2 GOLGA8J PTHR10881:SF62 GOLGIN SUBFAMILY A MEMBER-RELATED GOLGIN SUBFAMILY A CONSERVED DOMAIN-CONTAINING PROTEIN-RELATED Golgi organization#GO:0007030;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;endomembrane system organization#GO:0010256;cellular component organization or biogenesis#GO:0071840 membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;Golgi stack#GO:0005795;cis-Golgi network#GO:0005801;organelle membrane#GO:0031090;Golgi apparatus#GO:0005794;Golgi cisterna#GO:0031985;endomembrane system#GO:0012505;Golgi cis cisterna#GO:0000137;cytoplasm#GO:0005737;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791 membrane traffic protein#PC00150 HUMAN|HGNC=34295|UniProtKB=A6NML5 A6NML5 TMEM212 PTHR23320:SF130 MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED TRANSMEMBRANE PROTEIN 212 transporter#PC00227 HUMAN|HGNC=10643|UniProtKB=P80162 P80162 CXCL6 PTHR12015:SF201 SMALL INDUCIBLE CYTOKINE A C-X-C MOTIF CHEMOKINE 6 receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;chemokine activity#GO:0008009;G protein-coupled receptor binding#GO:0001664;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;cytokine activity#GO:0005125;binding#GO:0005488;cytokine receptor binding#GO:0005126;signaling receptor binding#GO:0005102;protein binding#GO:0005515;chemokine receptor binding#GO:0042379;molecular function activator activity#GO:0140677 cellular response to biotic stimulus#GO:0071216;cellular response to stimulus#GO:0051716;cell motility#GO:0048870;locomotion#GO:0040011;response to external biotic stimulus#GO:0043207;response to bacterium#GO:0009617;chemotaxis#GO:0006935;inflammatory response#GO:0006954;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;cell chemotaxis#GO:0060326;immune response#GO:0006955;cell migration#GO:0016477;response to other organism#GO:0051707;leukocyte migration#GO:0050900;cellular response to molecule of bacterial origin#GO:0071219;leukocyte chemotaxis#GO:0030595;defense response#GO:0006952;response to external stimulus#GO:0009605;myeloid leukocyte migration#GO:0097529;response to molecule of bacterial origin#GO:0002237;granulocyte chemotaxis#GO:0071621;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;immune system process#GO:0002376;cellular response to chemical stimulus#GO:0070887;response to oxygen-containing compound#GO:1901700;cellular response to lipopolysaccharide#GO:0071222;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;defense response to symbiont#GO:0140546;granulocyte migration#GO:0097530;defense response to other organism#GO:0098542;cellular response to lipid#GO:0071396;response to lipid#GO:0033993;neutrophil migration#GO:1990266;taxis#GO:0042330;response to chemical#GO:0042221;antimicrobial humoral response#GO:0019730;humoral immune response#GO:0006959;neutrophil chemotaxis#GO:0030593;response to lipopolysaccharide#GO:0032496 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 cytokine#PC00083 HUMAN|HGNC=29118|UniProtKB=O94886 O94886 TMEM63A PTHR13018:SF24 PROBABLE MEMBRANE PROTEIN DUF221-RELATED MECHANOSENSITIVE CATION CHANNEL TMEM63A monoatomic cation transmembrane transporter activity#GO:0008324;calcium-activated cation channel activity#GO:0005227;channel activity#GO:0015267;gated channel activity#GO:0022836;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation channel activity#GO:0005261;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic ion-gated channel activity#GO:0022839;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;ligand-gated monoatomic cation channel activity#GO:0099094;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 HUMAN|HGNC=14375|UniProtKB=O75807 O75807 PPP1R15A PTHR16489:SF14 GH11727P PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 15A molecular function regulator activity#GO:0098772;protein phosphatase regulator activity#GO:0019888;enzyme regulator activity#GO:0030234;phosphatase regulator activity#GO:0019208 response to stimulus#GO:0050896;response to stress#GO:0006950;response to endoplasmic reticulum stress#GO:0034976;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cellular response to stress#GO:0033554 endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endoplasmic reticulum#GO:0005783;protein serine/threonine phosphatase complex#GO:0008287;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=23711|UniProtKB=Q6NUK4 Q6NUK4 REEP3 PTHR12300:SF39 HVA22-LIKE PROTEINS RECEPTOR EXPRESSION-ENHANCING PROTEIN 3 tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;microtubule binding#GO:0008017;protein binding#GO:0005515 endomembrane system organization#GO:0010256;cellular component organization or biogenesis#GO:0071840;endoplasmic reticulum tubular network organization#GO:0071786;endoplasmic reticulum organization#GO:0007029;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996 cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;intracellular membrane-bounded organelle#GO:0043231;cytoplasmic microtubule#GO:0005881;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;supramolecular fiber#GO:0099512;membrane-bounded organelle#GO:0043227;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;supramolecular polymer#GO:0099081;endomembrane system#GO:0012505;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;membrane#GO:0016020;microtubule cytoskeleton#GO:0015630;endoplasmic reticulum tubular network#GO:0071782;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;cytoskeleton#GO:0005856;endoplasmic reticulum#GO:0005783 membrane traffic protein#PC00150 HUMAN|HGNC=33996|UniProtKB=P0DN37 P0DN37 PPIAL4G PTHR11071:SF466 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A-LIKE 4C-RELATED nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 chaperone#PC00072 HUMAN|HGNC=11547|UniProtKB=Q92804 Q92804 TAF15 PTHR23238:SF25 RNA BINDING PROTEIN TATA-BINDING PROTEIN-ASSOCIATED FACTOR 2N RNA binding#GO:0003723;transcription regulator activity#GO:0140110;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription coregulator activity#GO:0003712 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 RNA metabolism protein#PC00031 HUMAN|HGNC=10739|UniProtKB=Q9H3T3 Q9H3T3 SEMA6B PTHR11036:SF10 SEMAPHORIN SEMAPHORIN-6B signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;signaling receptor binding#GO:0005102;binding#GO:0005488;molecular function activator activity#GO:0140677;protein binding#GO:0005515 neuron development#GO:0048666;axonogenesis#GO:0007409;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;signaling#GO:0023052;cell development#GO:0048468;cell differentiation#GO:0030154;cell projection organization#GO:0030030;response to stimulus#GO:0050896;cell morphogenesis#GO:0000902;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;positive regulation of cell motility#GO:2000147;cellular component organization#GO:0016043;cell projection morphogenesis#GO:0048858;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell surface receptor signaling pathway#GO:0007166;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;neuron projection development#GO:0031175;system development#GO:0048731;regulation of cell motility#GO:2000145;cell communication#GO:0007154;anatomical structure development#GO:0048856;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;positive regulation of locomotion#GO:0040017;neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;regulation of cell migration#GO:0030334;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;regulation of locomotion#GO:0040012;multicellular organismal process#GO:0032501;positive regulation of cellular process#GO:0048522;positive regulation of cell migration#GO:0030335;axon guidance#GO:0007411;axon development#GO:0061564 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 membrane-bound signaling molecule#PC00152 HUMAN|HGNC=4855|UniProtKB=P19113 P19113 HDC PTHR11999:SF68 GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE HISTIDINE DECARBOXYLASE carbon-carbon lyase activity#GO:0016830;catalytic activity#GO:0003824;carboxy-lyase activity#GO:0016831;lyase activity#GO:0016829 metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;primary metabolic process#GO:0044238;amine metabolic process#GO:0009308;carboxylic acid metabolic process#GO:0019752;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;proteinogenic amino acid metabolic process#GO:0170039;biogenic amine metabolic process#GO:0006576;biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;small molecule catabolic process#GO:0044282 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 lyase#PC00144;decarboxylase#PC00089 CCKR signaling map#P06959>HDC#G07262;CCKR signaling map#P06959>HDC#G06969;Histamine synthesis#P04387>Histidine decarboxylase#P04493 HUMAN|HGNC=17572|UniProtKB=Q9UM22 Q9UM22 EPDR1 PTHR10697:SF1 MAMMALIAN EPENDYMIN-RELATED PROTEIN 1 MAMMALIAN EPENDYMIN-RELATED PROTEIN 1 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;lytic vacuole#GO:0000323;intracellular organelle#GO:0043229;vacuole#GO:0005773;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;lysosome#GO:0005764 HUMAN|HGNC=28028|UniProtKB=Q5VV52 Q5VV52 ZNF691 PTHR24404:SF102 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 691 cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244;DNA-binding transcription factor#PC00218 HUMAN|HGNC=4829|UniProtKB=P02042 P02042 HBD PTHR11442:SF50 HEMOGLOBIN FAMILY MEMBER HEMOGLOBIN SUBUNIT DELTA protein binding#GO:0005515;tetrapyrrole binding#GO:0046906;molecular carrier activity#GO:0140104;binding#GO:0005488;heme binding#GO:0020037 multicellular organismal-level homeostasis#GO:0048871;cellular developmental process#GO:0048869;establishment of localization#GO:0051234;developmental process#GO:0032502;transport#GO:0006810;hemopoiesis#GO:0030097;multicellular organismal process#GO:0032501;cellular process#GO:0009987;localization#GO:0051179;erythrocyte differentiation#GO:0030218;anatomical structure development#GO:0048856;homeostasis of number of cells#GO:0048872;immune system process#GO:0002376;homeostatic process#GO:0042592;cell development#GO:0048468;cell differentiation#GO:0030154;myeloid cell differentiation#GO:0030099 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytosol#GO:0005829 globin#PC00107;transfer/carrier protein#PC00219 HUMAN|HGNC=23116|UniProtKB=Q9HC62 Q9HC62 SENP2 PTHR12606:SF11 SENTRIN/SUMO-SPECIFIC PROTEASE SENTRIN-SPECIFIC PROTEASE 2 ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234 primary metabolic process#GO:0044238;protein modification process#GO:0036211;cellular process#GO:0009987;post-translational protein modification#GO:0043687;protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 protease#PC00190 HUMAN|HGNC=5921|UniProtKB=A0A075B6H9 A0A075B6H9 IGLV4-69 PTHR23267:SF164 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN LAMBDA VARIABLE 4-69 immune response#GO:0006955;immune system process#GO:0002376;response to stimulus#GO:0050896 protein-containing complex#GO:0032991 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=20811|UniProtKB=Q8N7K0 Q8N7K0 ZNF433 PTHR24379:SF94 KRAB AND ZINC FINGER DOMAIN-CONTAINING ZINC FINGER PROTEIN 433 DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264;zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=18854|UniProtKB=Q8TEY5 Q8TEY5 CREB3L4 PTHR45996:SF2 AGAP001464-PB CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 4 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 Transcription regulation by bZIP transcription factor#P00055>CREB#P01383;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>CREB#P00713;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>CPB#P00702 HUMAN|HGNC=20879|UniProtKB=Q8WXD9 Q8WXD9 CASKIN1 PTHR24174:SF11 ANKYRIN REPEAT AND STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 1 CASKIN-1 signaling#GO:0023052;regulation of cellular component biogenesis#GO:0044087;response to stimulus#GO:0050896;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;regulation of postsynapse organization#GO:0099175;regulation of organelle organization#GO:0033043;regulation of biological quality#GO:0065008;cell communication#GO:0007154;regulation of synapse structure or activity#GO:0050803;regulation of cell junction assembly#GO:1901888;regulation of synapse organization#GO:0050807;biological regulation#GO:0065007;regulation of synapse assembly#GO:0051963;regulation of organelle assembly#GO:1902115;signal transduction#GO:0007165;cellular process#GO:0009987 cell junction#GO:0030054;glutamatergic synapse#GO:0098978;cellular anatomical structure#GO:0110165;synapse#GO:0045202 scaffold/adaptor protein#PC00226 HUMAN|HGNC=700|UniProtKB=P27540 P27540 ARNT PTHR23042:SF50 CIRCADIAN PROTEIN CLOCK/ARNT/BMAL/PAS ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690 regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227;signaling receptor complex#GO:0043235;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;basic helix-loop-helix transcription factor#PC00055 Hypoxia response via HIF activation#P00030>HIF-1beta#P00820 HUMAN|HGNC=7794|UniProtKB=P19838 P19838 NFKB1 PTHR24169:SF9 NUCLEAR FACTOR NF-KAPPA-B PROTEIN NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 response to peptide#GO:1901652;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;immune system process#GO:0002376;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;positive regulation of transcription by RNA polymerase II#GO:0045944;intracellular signaling cassette#GO:0141124;response to chemical#GO:0042221;response to cytokine#GO:0034097;positive regulation of macromolecule metabolic process#GO:0010604;defense response to other organism#GO:0098542;non-canonical NF-kappaB signal transduction#GO:0038061;defense response to symbiont#GO:0140546;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;intracellular signal transduction#GO:0035556;regulation of RNA metabolic process#GO:0051252;cell communication#GO:0007154;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;response to external biotic stimulus#GO:0043207;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;response to external stimulus#GO:0009605;regulation of gene expression#GO:0010468;defense response#GO:0006952;regulation of biosynthetic process#GO:0009889;innate immune response#GO:0045087;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;response to other organism#GO:0051707;regulation of nucleobase-containing compound metabolic process#GO:0019219;canonical NF-kappaB signal transduction#GO:0007249;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;immune response#GO:0006955;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;Rel homology transcription factor#PC00252;DNA-binding transcription factor#PC00218 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>NFkappaB#P00859;Apoptosis signaling pathway#P00006>NFkappaB#P00297;B cell activation#P00010>NFkappaB#P00370;Toll receptor signaling pathway#P00054>NFkappaB#P01354;T cell activation#P00053>NFkappaB#P01298 HUMAN|HGNC=29410|UniProtKB=Q2NKQ1 Q2NKQ1 SGSM1 PTHR22957:SF187 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN SMALL G PROTEIN SIGNALING MODULATOR 1 GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme activator activity#GO:0008047 G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HUMAN|HGNC=11620|UniProtKB=Q14241 Q14241 ELOA PTHR15141:SF75 TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3 ELONGIN-A cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;DNA-templated transcription elongation#GO:0006354;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;transcription elongation by RNA polymerase II#GO:0006368;gene expression#GO:0010467;transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;transcription elongation factor complex#GO:0008023;intracellular membrane-bounded organelle#GO:0043231 general transcription factor#PC00259 HUMAN|HGNC=23194|UniProtKB=Q96EK4 Q96EK4 THAP11 PTHR22794:SF2 THAP DOMAIN PROTEIN 11 THAP DOMAIN-CONTAINING PROTEIN 11 transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634 HUMAN|HGNC=7510|UniProtKB=Q9UKN1 Q9UKN1 MUC12 PTHR24041:SF33 MUCIN MUCIN-12 cell adhesion molecule#PC00069 HUMAN|HGNC=3018|UniProtKB=P40879 P40879 SLC26A3 PTHR11814:SF19 SULFATE TRANSPORTER CHLORIDE ANION EXCHANGER carboxylic acid transmembrane transporter activity#GO:0046943;dicarboxylic acid transmembrane transporter activity#GO:0005310;monoatomic ion transmembrane transporter activity#GO:0015075;active transmembrane transporter activity#GO:0022804;bicarbonate transmembrane transporter activity#GO:0015106;antiporter activity#GO:0015297;chloride transmembrane transporter activity#GO:0015108;monoatomic anion transmembrane transporter activity#GO:0008509;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 localization#GO:0051179;chloride transmembrane transport#GO:1902476;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;inorganic anion transport#GO:0015698;monoatomic ion transport#GO:0006811;chloride transport#GO:0006821;transport#GO:0006810;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220;monoatomic anion transport#GO:0006820;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227 HUMAN|HGNC=24967|UniProtKB=Q9H081 Q9H081 MIS12 PTHR14527:SF2 PROTEIN MIS12 HOMOLOG PROTEIN MIS12 HOMOLOG mitotic sister chromatid segregation#GO:0000070;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cellular component assembly#GO:0022607;chromosome segregation#GO:0007059;cellular component organization or biogenesis#GO:0071840;mitotic cell cycle process#GO:1903047;protein-containing complex organization#GO:0043933;chromosome organization#GO:0051276;cell cycle#GO:0007049;membraneless organelle assembly#GO:0140694;nuclear chromosome segregation#GO:0098813;cellular component organization#GO:0016043;sister chromatid segregation#GO:0000819;protein-containing complex assembly#GO:0065003;cell cycle process#GO:0022402;mitotic nuclear division#GO:0140014;mitotic cell cycle#GO:0000278;organelle assembly#GO:0070925;nuclear division#GO:0000280;kinetochore assembly#GO:0051382;kinetochore organization#GO:0051383;organelle fission#GO:0048285 intracellular organelle#GO:0043229;chromosome, centromeric region#GO:0000775;condensed chromosome#GO:0000793;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;outer kinetochore#GO:0000940;kinetochore#GO:0000776;condensed chromosome, centromeric region#GO:0000779;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;supramolecular complex#GO:0099080 HUMAN|HGNC=19853|UniProtKB=Q6PJG2 Q6PJG2 MIDEAS PTHR16089:SF24 REST COREPRESSOR COREST PROTEIN-RELATED MITOTIC DEACETYLASE-ASSOCIATED SANT DOMAIN PROTEIN transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714;transcription regulator activity#GO:0140110 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of macromolecule metabolic process#GO:0010605;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789 organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;histone deacetylase complex#GO:0000118;membrane-enclosed lumen#GO:0031974;protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667;nuclear protein-containing complex#GO:0140513 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=12761|UniProtKB=P30291 P30291 WEE1 PTHR11042:SF72 EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED WEE1-LIKE PROTEIN KINASE catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein tyrosine kinase activity#GO:0004713;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 regulation of mitotic cell cycle phase transition#GO:1901990;regulation of G2/M transition of mitotic cell cycle#GO:0010389;negative regulation of mitotic cell cycle#GO:0045930;regulation of cellular process#GO:0050794;regulation of cell cycle#GO:0051726;regulation of cell cycle phase transition#GO:1901987;negative regulation of biological process#GO:0048519;negative regulation of cell cycle phase transition#GO:1901988;regulation of biological process#GO:0050789;negative regulation of cell cycle#GO:0045786;negative regulation of cell cycle G2/M phase transition#GO:1902750;negative regulation of cellular process#GO:0048523;negative regulation of cell cycle process#GO:0010948;negative regulation of mitotic cell cycle phase transition#GO:1901991;negative regulation of G2/M transition of mitotic cell cycle#GO:0010972;biological regulation#GO:0065007;regulation of cell cycle process#GO:0010564;regulation of cell cycle G2/M phase transition#GO:1902749;regulation of mitotic cell cycle#GO:0007346 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=4597|UniProtKB=P41594 P41594 GRM5 PTHR24060:SF30 METABOTROPIC GLUTAMATE RECEPTOR METABOTROPIC GLUTAMATE RECEPTOR 5 glutamate receptor activity#GO:0008066;adenylate cyclase inhibiting G protein-coupled glutamate receptor activity#GO:0001640;transmembrane signaling receptor activity#GO:0004888;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 regulation of trans-synaptic signaling#GO:0099177;biological regulation#GO:0065007;signal transduction#GO:0007165;cellular process#GO:0009987;cell surface receptor signaling pathway#GO:0007166;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;regulation of synaptic transmission, glutamatergic#GO:0051966;cell communication#GO:0007154;glutamate receptor signaling pathway#GO:0007215;G protein-coupled receptor signaling pathway#GO:0007186;regulation of signaling#GO:0023051 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;neuron to neuron synapse#GO:0098984;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;synaptic membrane#GO:0097060;cell junction#GO:0030054;postsynapse#GO:0098794;synapse#GO:0045202;cellular anatomical structure#GO:0110165;asymmetric synapse#GO:0032279;organelle#GO:0043226;postsynaptic density#GO:0014069;postsynaptic specialization membrane#GO:0099634;postsynaptic membrane#GO:0045211;postsynaptic density membrane#GO:0098839 G-protein coupled receptor#PC00021 Metabotropic glutamate receptor group I pathway#P00041>mGluR5#P01061;Metabotropic glutamate receptor group III pathway#P00039>mGluR 5#P01037;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GoPCR#P00725;Metabotropic glutamate receptor group I pathway#P00041>mGluR1#P01062;Endogenous cannabinoid signaling#P05730>mGluR#P05748;Metabotropic glutamate receptor group III pathway#P00039>mGluR 1/5#P01040;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GqPCR#P00730 HUMAN|HGNC=21863|UniProtKB=Q9NW13 Q9NW13 RBM28 PTHR48039:SF7 RNA-BINDING MOTIF PROTEIN 14B RNA-BINDING PROTEIN 28 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=15308|UniProtKB=Q8N162 Q8N162 OR8H2 PTHR48018:SF175 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 8H2 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;nervous system process#GO:0050877;sensory perception#GO:0007600;sensory perception of smell#GO:0007608;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=1665|UniProtKB=Q14108 Q14108 SCARB2 PTHR11923:SF118 SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1 LYSOSOME MEMBRANE PROTEIN 2 cargo receptor activity#GO:0038024 establishment of protein localization to vacuole#GO:0072666;protein targeting#GO:0006605;protein localization to organelle#GO:0033365;endocytosis#GO:0006897;protein localization to lysosome#GO:0061462;localization#GO:0051179;cellular localization#GO:0051641;protein transport#GO:0015031;lysosomal transport#GO:0007041;protein localization to vacuole#GO:0072665;vesicle-mediated transport#GO:0016192;macromolecule localization#GO:0033036;protein targeting to vacuole#GO:0006623;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;import into cell#GO:0098657;intracellular protein localization#GO:0008104;receptor-mediated endocytosis#GO:0006898;intracellular transport#GO:0046907;vacuolar transport#GO:0007034;transport#GO:0006810;intracellular protein transport#GO:0006886 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;lysosome#GO:0005764;lytic vacuole membrane#GO:0098852;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;vacuolar membrane#GO:0005774;lytic vacuole#GO:0000323;cytoplasm#GO:0005737;vacuole#GO:0005773;plasma membrane#GO:0005886;lysosomal membrane#GO:0005765;cell periphery#GO:0071944;membrane#GO:0016020 membrane trafficking regulatory protein#PC00151;membrane traffic protein#PC00150 HUMAN|HGNC=2093|UniProtKB=P53675 P53675 CLTCL1 PTHR10292:SF6 CLATHRIN HEAVY CHAIN RELATED CLATHRIN HEAVY CHAIN 2 clathrin binding#GO:0030276;binding#GO:0005488;protein binding#GO:0005515 localization#GO:0051179;import into cell#GO:0098657;establishment of localization#GO:0051234;receptor-mediated endocytosis#GO:0006898;transport#GO:0006810;vesicle-mediated transport#GO:0016192;endocytosis#GO:0006897;cellular process#GO:0009987 intracellular organelle#GO:0043229;membrane coat#GO:0030117;coated membrane#GO:0048475;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;coated vesicle#GO:0030135;endocytic vesicle#GO:0030139;membrane-bounded organelle#GO:0043227;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;vesicle#GO:0031982;clathrin coat#GO:0030118;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;clathrin-coated vesicle#GO:0030136;clathrin-coated endocytic vesicle#GO:0045334;membrane#GO:0016020;protein-containing complex#GO:0032991;cytoplasm#GO:0005737 vesicle coat protein#PC00235;membrane traffic protein#PC00150 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Clathrin#P00738;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Clathrin#P00722 HUMAN|HGNC=16380|UniProtKB=Q13049 Q13049 TRIM32 PTHR25464:SF3 TRIPARTITE MOTIF-CONTAINING PROTEIN 2-LIKE PROTEIN E3 UBIQUITIN-PROTEIN LIGASE TRIM32 ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740 cellular response to amino acid starvation#GO:0034198;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;response to stress#GO:0006950;regulation of response to cytokine stimulus#GO:0060759;positive regulation of autophagy#GO:0010508;regulation of cytokine-mediated signaling pathway#GO:0001959;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;regulation of autophagy#GO:0010506;positive regulation of cytokine-mediated signaling pathway#GO:0001961;positive regulation of signaling#GO:0023056;positive regulation of metabolic process#GO:0009893;regulation of signaling#GO:0023051;cellular response to stress#GO:0033554;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;response to nutrient levels#GO:0031667;regulation of catabolic process#GO:0009894;positive regulation of catabolic process#GO:0009896;regulation of response to stimulus#GO:0048583;cellular response to nutrient levels#GO:0031669;cellular response to starvation#GO:0009267;regulation of cell communication#GO:0010646;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;response to starvation#GO:0042594 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=371|UniProtKB=Q12802 Q12802 AKAP13 PTHR13944:SF18 AGAP007712-PA A-KINASE ANCHOR PROTEIN 13 protein complex scaffold activity#GO:0140378;molecular adaptor activity#GO:0060090;structural molecule activity#GO:0005198;molecular function regulator activity#GO:0098772;MAP kinase scaffold activity#GO:0005078;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;guanyl-nucleotide exchange factor activity#GO:0005085;protein-macromolecule adaptor activity#GO:0030674;signaling adaptor activity#GO:0035591;enzyme regulator activity#GO:0030234 regulation of small GTPase mediated signal transduction#GO:0051056;positive regulation of canonical NF-kappaB signal transduction#GO:0043123;positive regulation of MAPK cascade#GO:0043410;regulation of response to stimulus#GO:0048583;regulation of MAPK cascade#GO:0043408;positive regulation of intracellular signal transduction#GO:1902533;intracellular signaling cassette#GO:0141124;regulation of signal transduction#GO:0009966;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;cellular process#GO:0009987;regulation of canonical NF-kappaB signal transduction#GO:0043122;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165;intracellular signal transduction#GO:0035556;positive regulation of signaling#GO:0023056;cell communication#GO:0007154;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;regulation of cell communication#GO:0010646;signaling#GO:0023052;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of Rho protein signal transduction#GO:0035023;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;actin cytoskeleton#GO:0015629;membrane#GO:0016020 HUMAN|HGNC=19731|UniProtKB=Q6PKH6 Q6PKH6 DHRS4L2 PTHR43943:SF8 DEHYDROGENASE/REDUCTASE (SDR FAMILY) MEMBER 4 DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 4-RELATED oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;alcohol dehydrogenase (NADP+) activity#GO:0008106;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;catalytic activity#GO:0003824 metabolite interconversion enzyme#PC00262;dehydrogenase#PC00092 HUMAN|HGNC=26668|UniProtKB=Q5VTL7 Q5VTL7 FNDC7 PTHR47135:SF1 FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN 7 FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN 7 HUMAN|HGNC=15454|UniProtKB=Q9UQ13 Q9UQ13 SHOC2 PTHR45752:SF26 LEUCINE-RICH REPEAT-CONTAINING LEUCINE-RICH REPEAT PROTEIN SHOC-2 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic anion transmembrane transporter activity#GO:0008509;passive transmembrane transporter activity#GO:0022803;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;channel activity#GO:0015267;monoatomic anion channel activity#GO:0005253 cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;monoatomic anion transmembrane transport#GO:0098656;acidic amino acid transport#GO:0015800;amino acid transport#GO:0006865;carboxylic acid transport#GO:0046942;cell surface receptor signaling pathway#GO:0007166;organic acid transport#GO:0015849;cellular response to nerve growth factor stimulus#GO:1990090;import into cell#GO:0098657;regulation of small GTPase mediated signal transduction#GO:0051056;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;import across plasma membrane#GO:0098739;signaling#GO:0023052;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;cellular response to growth factor stimulus#GO:0071363;nitrogen compound transport#GO:0071705;aspartate transmembrane transport#GO:0015810;positive regulation of cellular process#GO:0048522;positive regulation of response to stimulus#GO:0048584;dicarboxylic acid transport#GO:0006835;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;C4-dicarboxylate transport#GO:0015740;regulation of response to stimulus#GO:0048583;transport#GO:0006810;positive regulation of intracellular signal transduction#GO:1902533;establishment of localization#GO:0051234;monoatomic anion transport#GO:0006820;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;carbohydrate derivative transport#GO:1901264;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;organophosphate ester transport#GO:0015748;nucleobase-containing compound transport#GO:0015931;response to growth factor#GO:0070848;carboxylic acid transmembrane transport#GO:1905039;regulation of cell communication#GO:0010646;amino acid transmembrane transport#GO:0003333;cell communication#GO:0007154;localization#GO:0051179;regulation of Ras protein signal transduction#GO:0046578;intracellular signal transduction#GO:0035556 intracellular anatomical structure#GO:0005622;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;membrane#GO:0016020;membrane protein complex#GO:0098796;cytoplasm#GO:0005737;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=3666|UniProtKB=O15520 O15520 FGF10 PTHR11486:SF21 FIBROBLAST GROWTH FACTOR FIBROBLAST GROWTH FACTOR 10 signaling receptor regulator activity#GO:0030545;growth factor activity#GO:0008083;growth factor receptor binding#GO:0070851;receptor ligand activity#GO:0048018;fibroblast growth factor receptor binding#GO:0005104;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515;molecular function activator activity#GO:0140677 positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;response to growth factor#GO:0070848;locomotion#GO:0040011;regulation of cell communication#GO:0010646;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;chemotaxis#GO:0006935;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;regulation of cell motility#GO:2000145;system development#GO:0048731;response to wounding#GO:0009611;positive regulation of cellular process#GO:0048522;multicellular organismal process#GO:0032501;fibroblast growth factor receptor signaling pathway#GO:0008543;positive regulation of response to stimulus#GO:0048584;regulation of locomotion#GO:0040012;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;response to fibroblast growth factor#GO:0071774;regulation of response to stimulus#GO:0048583;regulation of cell migration#GO:0030334;developmental process#GO:0032502;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of MAPK cascade#GO:0043410;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;response to external stimulus#GO:0009605;response to endogenous stimulus#GO:0009719;positive regulation of cell population proliferation#GO:0008284;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cell differentiation#GO:0030154;cellular response to endogenous stimulus#GO:0071495;signaling#GO:0023052;regulation of intracellular signal transduction#GO:1902531;animal gross anatomical part developmental process#GO:0160108;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;wound healing#GO:0042060;cellular response to growth factor stimulus#GO:0071363;response to stress#GO:0006950;positive chemotaxis#GO:0050918;cellular process#GO:0009987;cellular response to fibroblast growth factor stimulus#GO:0044344;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;taxis#GO:0042330;response to chemical#GO:0042221;nervous system development#GO:0007399;cell surface receptor signaling pathway#GO:0007166;regulation of MAPK cascade#GO:0043408;multicellular organism development#GO:0007275 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 intercellular signal molecule#PC00207;growth factor#PC00112 FGF signaling pathway#P00021>FGF#P00623 HUMAN|HGNC=13339|UniProtKB=O95239 O95239 KIF4A PTHR47969:SF15 CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED polypeptide conformation or assembly isomerase activity#GO:0120544;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543;ATP-dependent activity#GO:0140657;cytoskeletal motor activity#GO:0003774;isomerase activity#GO:0016853;microtubule motor activity#GO:0003777 mitotic spindle organization#GO:0007052;mitotic cell cycle#GO:0000278;cell cycle process#GO:0022402;microtubule cytoskeleton organization involved in mitosis#GO:1902850;nuclear chromosome segregation#GO:0098813;cellular component organization#GO:0016043;cell cycle#GO:0007049;microtubule cytoskeleton organization#GO:0000226;spindle elongation#GO:0051231;cytoskeleton organization#GO:0007010;cellular process#GO:0009987;organelle organization#GO:0006996;microtubule-based process#GO:0007017;mitotic cell cycle process#GO:1903047;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;chromosome segregation#GO:0007059 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 microtubule binding motor protein#PC00156;cytoskeletal protein#PC00085 HUMAN|HGNC=4839|UniProtKB=P51610 P51610 HCFC1 PTHR46003:SF3 HOST CELL FACTOR HOST CELL FACTOR 1 transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;transcription coactivator activity#GO:0003713 regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;chromatin remodeling#GO:0006338;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;methyltransferase complex#GO:0034708;nucleoplasm#GO:0005654;organelle#GO:0043226;organelle lumen#GO:0043233;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;nuclear protein-containing complex#GO:0140513;histone methyltransferase complex#GO:0035097;transferase complex#GO:1990234 HUMAN|HGNC=43444|UniProtKB=P0CAP1 P0CAP1 MYZAP PTHR23171:SF2 GDOWN1 MYOCARDIAL ZONULA ADHERENS PROTEIN myofibril#GO:0030016;supramolecular fiber#GO:0099512;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;organelle lumen#GO:0043233;nuclear protein-containing complex#GO:0140513;sarcomere#GO:0030017;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;contractile muscle fiber#GO:0043292;RNA polymerase II, holoenzyme#GO:0016591;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;catalytic complex#GO:1902494;RNA polymerase II, core complex#GO:0005665;intracellular membrane-bounded organelle#GO:0043231;nuclear DNA-directed RNA polymerase complex#GO:0055029;membraneless organelle#GO:0043228;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;I band#GO:0031674;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;RNA polymerase complex#GO:0030880 DNA-directed RNA polymerase#PC00019;RNA metabolism protein#PC00031 HUMAN|HGNC=21427|UniProtKB=A6NDV4 A6NDV4 TMEM8B PTHR14319:SF6 FIVE-SPAN TRANSMEMBRANE PROTEIN M83 TRANSMEMBRANE PROTEIN 8B cell adhesion molecule#PC00069 HUMAN|HGNC=27365|UniProtKB=Q5HYJ1 Q5HYJ1 TECRL PTHR10556:SF27 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE TRANS-2,3-ENOYL-COA REDUCTASE-LIKE catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;oxidoreductase activity#GO:0016491 oxoacid metabolic process#GO:0043436;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid biosynthetic process#GO:0046394;small molecule metabolic process#GO:0044281;very long-chain fatty acid metabolic process#GO:0000038;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;sphingolipid metabolic process#GO:0006665;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;monocarboxylic acid biosynthetic process#GO:0072330;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;fatty acid biosynthetic process#GO:0006633;biosynthetic process#GO:0009058 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=25660|UniProtKB=Q7Z4L5 Q7Z4L5 TTC21B PTHR14699:SF1 STI2 PROTEIN-RELATED TETRATRICOPEPTIDE REPEAT PROTEIN 21B microtubule-based process#GO:0007017;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;cellular component organization or biogenesis#GO:0071840;transport#GO:0006810;intracellular transport#GO:0046907;plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton-dependent intracellular transport#GO:0030705;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;macromolecule localization#GO:0033036;organelle organization#GO:0006996;cilium organization#GO:0044782;cellular localization#GO:0051641;localization#GO:0051179;microtubule-based transport#GO:0099111;intraciliary transport#GO:0042073;protein localization to cilium#GO:0061512;intraciliary retrograde transport#GO:0035721;microtubule-based movement#GO:0007018;protein localization to organelle#GO:0033365;cell projection organization#GO:0030030;cellular component organization#GO:0016043 intraciliary transport particle#GO:0030990;protein-containing complex#GO:0032991;intraciliary transport particle A#GO:0030991 HUMAN|HGNC=24071|UniProtKB=P0DPH8 P0DPH8 TUBA3D PTHR11588:SF113 TUBULIN TUBULIN ALPHA-3D CHAIN purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;structural constituent of cytoskeleton#GO:0005200;binding#GO:0005488;nucleoside phosphate binding#GO:1901265;guanyl nucleotide binding#GO:0019001;structural molecule activity#GO:0005198;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;anion binding#GO:0043168;ion binding#GO:0043167 cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226;microtubule-based process#GO:0007017;mitotic cell cycle#GO:0000278;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cell cycle#GO:0007049;cellular component organization#GO:0016043;cellular process#GO:0009987 supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;organelle#GO:0043226;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;microtubule cytoskeleton#GO:0015630 cytoskeletal protein#PC00085;tubulin#PC00228 HUMAN|HGNC=11986|UniProtKB=P11387 P11387 TOP1 PTHR10290:SF5 DNA TOPOISOMERASE I DNA TOPOISOMERASE 1 macromolecular conformation isomerase activity#GO:0120543;catalytic activity#GO:0003824;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;isomerase activity#GO:0016853;catalytic activity, acting on DNA#GO:0140097 metabolic process#GO:0008152;DNA metabolic process#GO:0006259;chromosome segregation#GO:0007059;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;chromosome organization#GO:0051276;cell cycle#GO:0007049;organelle organization#GO:0006996;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;cell cycle process#GO:0022402;cellular process#GO:0009987;DNA replication#GO:0006260;nucleobase-containing compound metabolic process#GO:0006139 nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231 DNA topoisomerase#PC00017;DNA metabolism protein#PC00009 DNA replication#P00017>DNA Topisomerase#P00536;DNA replication#P00017>Top#P00530 HUMAN|HGNC=28643|UniProtKB=Q7Z398 Q7Z398 ZNF550 PTHR24381:SF154 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 550 transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=14704|UniProtKB=Q8NGS6 Q8NGS6 OR13C3 PTHR26453:SF34 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 13C3 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 detection of chemical stimulus#GO:0009593;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;response to chemical#GO:0042221;response to stimulus#GO:0050896;nervous system process#GO:0050877;sensory perception#GO:0007600;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;system process#GO:0003008 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=12705|UniProtKB=O95497 O95497 VNN1 PTHR10609:SF16 BIOTINIDASE-RELATED PANTETHEINASE hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810 small molecule metabolic process#GO:0044281;cellular process#GO:0009987;carboxylic acid metabolic process#GO:0019752;modified amino acid metabolic process#GO:0006575;monocarboxylic acid metabolic process#GO:0032787;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436 hydrolase#PC00121 HUMAN|HGNC=19663|UniProtKB=Q9UBI6 Q9UBI6 GNG12 PTHR13809:SF9 GUANINE NUCLEOTIDE-BINDING PROTEIN GAMMA SUBUNIT GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)_G(S)_G(O) SUBUNIT GAMMA-12 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;molecular function regulator activity#GO:0098772 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 extrinsic component of plasma membrane#GO:0019897;side of membrane#GO:0098552;extrinsic component of membrane#GO:0019898;extrinsic component of cytoplasmic side of plasma membrane#GO:0031234;cytoplasmic side of membrane#GO:0098562;catalytic complex#GO:1902494;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane#GO:0016020;cytoplasmic side of plasma membrane#GO:0009898;membrane protein complex#GO:0098796 heterotrimeric G-protein#PC00117 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GIRK#P00743;Wnt signaling pathway#P00057>Ggamma#P01465;Metabotropic glutamate receptor group II pathway#P00040>G-protein#P01047;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Ggamma#P00726;Beta1 adrenergic receptor signaling pathway#P04377>G-Protein#P04436;Opioid prodynorphin pathway#P05916>G-protein#P06002;Beta3 adrenergic receptor signaling pathway#P04379>G-Protein#P04448;5HT1 type receptor mediated signaling pathway#P04373>G-protein#P04408;Opioid proenkephalin pathway#P05915>G-protein#P05994;Histamine H1 receptor mediated signaling pathway#P04385>G-Protein#P04488;Beta2 adrenergic receptor signaling pathway#P04378>G-Protein#P04443;Histamine H2 receptor mediated signaling pathway#P04386>G-Protein#P04490;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Ggamma#P00721;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Gbetagamma#P00836;Enkephalin release#P05913>G-Protein (s)#P05977;Enkephalin release#P05913>G-Protein (i)#P05974;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Ggamma#P00751;5HT2 type receptor mediated signaling pathway#P04374>G-protein#P04416;Thyrotropin-releasing hormone receptor signaling pathway#P04394>G-Protein#P04584;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>G-Protein#P01085;Cortocotropin releasing factor receptor signaling pathway#P04380>G-Protein#P04458;Oxytocin receptor mediated signaling pathway#P04391>G-Protein#P04534;Opioid proopiomelanocortin pathway#P05917>G-protein#P06012;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>G-Protein#P01073;5HT4 type receptor mediated signaling pathway#P04376>G-protein#P04430 HUMAN|HGNC=51251|UniProtKB=A0A087WV53 A0A087WV53 SPEGNB PTHR47633:SF8 IMMUNOGLOBULIN SPEG NEIGHBOR PROTEIN HUMAN|HGNC=53903|UniProtKB=A0A2R8YFM6 A0A2R8YFM6 OOSP3 PTHR14380:SF10 PLACENTA-SPECIFIC PROTEIN 1 OOCYTE-SECRETED PROTEIN 3 HUMAN|HGNC=14630|UniProtKB=Q96HD1 Q96HD1 CRELD1 PTHR24034:SF114 EGF-LIKE DOMAIN-CONTAINING PROTEIN PROTEIN DISULFIDE ISOMERASE CRELD1 cellular anatomical structure#GO:0110165;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576 extracellular matrix structural protein#PC00103;extracellular matrix protein#PC00102 HUMAN|HGNC=20064|UniProtKB=Q9H0E7 Q9H0E7 USP44 PTHR21646:SF15 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 44 deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;cysteine-type deubiquitinase activity#GO:0004843;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783 regulation of protein stability#GO:0031647;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of biological quality#GO:0065008;biological regulation#GO:0065007;regulation of cell cycle process#GO:0010564;regulation of cell cycle#GO:0051726 cysteine protease#PC00081 HUMAN|HGNC=5958|UniProtKB=Q13123 Q13123 IK PTHR12765:SF7 RED PROTEIN IK FACTOR CYTOKINE IK PROTEIN RED RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 cytokine#PC00083 HUMAN|HGNC=28101|UniProtKB=Q2M2H8 Q2M2H8 MGAM2 PTHR22762:SF122 ALPHA-GLUCOSIDASE MALTASE-GLUCOAMYLASE 2-RELATED hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824;glucosidase activity#GO:0015926;alpha-glucosidase activity#GO:0090599;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787 glucosidase#PC00108 HUMAN|HGNC=18302|UniProtKB=Q9NU22 Q9NU22 MDN1 PTHR48103:SF2 MIDASIN-RELATED MIDASIN ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP-dependent activity#GO:0140657 ribosome assembly#GO:0042255;organelle assembly#GO:0070925;ribosomal large subunit biogenesis#GO:0042273;ribosome biogenesis#GO:0042254;protein-RNA complex assembly#GO:0022618;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;ribonucleoprotein complex biogenesis#GO:0022613;cellular component organization or biogenesis#GO:0071840;protein-RNA complex organization#GO:0071826;protein-containing complex organization#GO:0043933;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;ribosomal large subunit assembly#GO:0000027;cellular process#GO:0009987;cellular component assembly#GO:0022607 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=6040|UniProtKB=Q13418 Q13418 ILK PTHR44329:SF57 SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED SCAFFOLD PROTEIN ILK catalytic activity, acting on a protein#GO:0140096;molecular adaptor activity#GO:0060090;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;protein binding#GO:0005515;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein-macromolecule adaptor activity#GO:0030674;protein serine/threonine kinase activity#GO:0004674;signaling receptor binding#GO:0005102;binding#GO:0005488 biological regulation#GO:0065007;signal transduction#GO:0007165;cellular process#GO:0009987;cellular developmental process#GO:0048869;developmental process#GO:0032502;substrate adhesion-dependent cell spreading#GO:0034446;cell surface receptor signaling pathway#GO:0007166;signaling#GO:0023052;response to stimulus#GO:0050896;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;integrin-mediated signaling pathway#GO:0007229;cell communication#GO:0007154;cell-substrate adhesion#GO:0031589;cell-matrix adhesion#GO:0007160;cell adhesion#GO:0007155 cellular anatomical structure#GO:0110165;cell junction#GO:0030054;anchoring junction#GO:0070161;cell-substrate junction#GO:0030055;focal adhesion#GO:0005925 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Integrin signalling pathway#P00034>ILK#P00935 HUMAN|HGNC=6225|UniProtKB=P17658 P17658 KCNA6 PTHR11537:SF104 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 6 channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;potassium channel activity#GO:0005267;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215 action potential#GO:0001508;metal ion transport#GO:0030001;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;potassium ion transport#GO:0006813;transport#GO:0006810;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391 voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702 voltage-gated ion channel#PC00241;ion channel#PC00133 HUMAN|HGNC=33435|UniProtKB=Q5U4N7 Q5U4N7 GDF5-AS1 PTHR42152:SF1 PROTEIN GDF5OS, MITOCHONDRIAL PROTEIN GDF5-AS1, MITOCHONDRIAL HUMAN|HGNC=16257|UniProtKB=Q9H4B7 Q9H4B7 TUBB1 PTHR11588:SF112 TUBULIN TUBULIN BETA-1 CHAIN structural molecule activity#GO:0005198;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;anion binding#GO:0043168;ion binding#GO:0043167;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;ribonucleotide binding#GO:0032553;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;guanyl nucleotide binding#GO:0019001;structural constituent of cytoskeleton#GO:0005200;binding#GO:0005488;nucleoside phosphate binding#GO:1901265 cellular process#GO:0009987;cellular component organization#GO:0016043;cell cycle#GO:0007049;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;mitotic cell cycle#GO:0000278;microtubule-based process#GO:0007017;microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840 supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;supramolecular complex#GO:0099080;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;microtubule cytoskeleton#GO:0015630 cytoskeletal protein#PC00085;tubulin#PC00228 Cytoskeletal regulation by Rho GTPase#P00016>tubulin#P00526;Huntington disease#P00029>Microtubule#P00780;Huntington disease#P00029>beta-Tubulin#P00790 HUMAN|HGNC=15713|UniProtKB=Q9UJX4 Q9UJX4 ANAPC5 PTHR12830:SF9 ANAPHASE-PROMOTING COMPLEX SUBUNIT 5 ANAPHASE-PROMOTING COMPLEX SUBUNIT 5 protein modification by small protein conjugation or removal#GO:0070647;modification-dependent macromolecule catabolic process#GO:0043632;anaphase-promoting complex-dependent catabolic process#GO:0031145;positive regulation of cellular component organization#GO:0051130;protein catabolic process#GO:0030163;positive regulation of organelle organization#GO:0010638;regulation of mitotic cell cycle phase transition#GO:1901990;protein K11-linked ubiquitination#GO:0070979;regulation of organelle organization#GO:0033043;protein modification by small protein conjugation#GO:0032446;positive regulation of cell cycle process#GO:0090068;regulation of biological process#GO:0050789;protein polyubiquitination#GO:0000209;regulation of cellular component organization#GO:0051128;regulation of sister chromatid segregation#GO:0033045;regulation of cell cycle#GO:0051726;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;positive regulation of mitotic nuclear division#GO:0045840;regulation of chromosome segregation#GO:0051983;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;regulation of chromosome separation#GO:1905818;proteasomal protein catabolic process#GO:0010498;positive regulation of cell cycle#GO:0045787;protein ubiquitination#GO:0016567;regulation of cell cycle process#GO:0010564;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;protein modification process#GO:0036211;regulation of cell cycle phase transition#GO:1901987;modification-dependent protein catabolic process#GO:0019941;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;regulation of chromosome organization#GO:0033044;regulation of mitotic sister chromatid separation#GO:0010965;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;positive regulation of mitotic cell cycle#GO:0045931;regulation of mitotic nuclear division#GO:0007088;regulation of mitotic cell cycle#GO:0007346;positive regulation of cellular process#GO:0048522;regulation of mitotic metaphase/anaphase transition#GO:0030071;post-translational protein modification#GO:0043687;regulation of nuclear division#GO:0051783;biological regulation#GO:0065007 protein-containing complex#GO:0032991;anaphase-promoting complex#GO:0005680;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;cellular anatomical structure#GO:0110165;nuclear ubiquitin ligase complex#GO:0000152;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cullin-RING ubiquitin ligase complex#GO:0031461;ubiquitin ligase complex#GO:0000151;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;catalytic complex#GO:1902494 HUMAN|HGNC=22398|UniProtKB=Q96EE4 Q96EE4 CCDC126 PTHR46941:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 126 COILED-COIL DOMAIN-CONTAINING PROTEIN 126 HUMAN|HGNC=1504|UniProtKB=P42574 P42574 CASP3 PTHR10454:SF198 CASPASE CASPASE-3 enzyme activator activity#GO:0008047;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;molecular function regulator activity#GO:0098772;peptidase activity#GO:0008233;cysteine-type endopeptidase activity#GO:0004197;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;molecular function activator activity#GO:0140677;hydrolase activity#GO:0016787;enzyme regulator activity#GO:0030234 keratinocyte differentiation#GO:0030216;homeostasis of number of cells#GO:0048872;anatomical structure development#GO:0048856;protein metabolic process#GO:0019538;erythrocyte differentiation#GO:0030218;system development#GO:0048731;primary metabolic process#GO:0044238;programmed cell death#GO:0012501;cell death#GO:0008219;regulation of cellular process#GO:0050794;homeostatic process#GO:0042592;epidermis development#GO:0008544;positive regulation of neuron apoptotic process#GO:0043525;developmental process#GO:0032502;cellular developmental process#GO:0048869;macromolecule metabolic process#GO:0043170;neurogenesis#GO:0022008;multicellular organismal-level homeostasis#GO:0048871;positive regulation of cellular process#GO:0048522;multicellular organismal process#GO:0032501;epidermal cell differentiation#GO:0009913;epithelial cell differentiation#GO:0030855;tissue development#GO:0009888;epithelium development#GO:0060429;hemopoiesis#GO:0030097;biological regulation#GO:0065007;animal gross anatomical part developmental process#GO:0160108;proteolysis#GO:0006508;immune system process#GO:0002376;generation of neurons#GO:0048699;regulation of programmed cell death#GO:0043067;apoptotic process#GO:0006915;execution phase of apoptosis#GO:0097194;regulation of biological process#GO:0050789;positive regulation of programmed cell death#GO:0043068;myeloid cell differentiation#GO:0030099;cell differentiation#GO:0030154;cell development#GO:0048468;metabolic process#GO:0008152;regulation of apoptotic process#GO:0042981;neuron differentiation#GO:0030182;animal organ development#GO:0048513;multicellular organism development#GO:0007275;positive regulation of apoptotic process#GO:0043065;regulation of neuron apoptotic process#GO:0043523;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;nervous system development#GO:0007399;skin development#GO:0043588 cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane#GO:0016020;membrane protein complex#GO:0098796;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;protease#PC00190 CCKR signaling map#P06959>Pro-caspase-3#P07231;Apoptosis signaling pathway#P00006>Caspase 3#P00305;FAS signaling pathway#P00020>Caspase3#P00599;CCKR signaling map#P06959>Caspase-3#P07108;FAS signaling pathway#P00020>Pro-Caspase3#P00608;Huntington disease#P00029>Caspase 3#P00812 HUMAN|HGNC=18044|UniProtKB=Q99624 Q99624 SLC38A3 PTHR22950:SF22 AMINO ACID TRANSPORTER SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 3 basic amino acid transmembrane transporter activity#GO:0015174;aromatic amino acid transmembrane transporter activity#GO:0015173;carboxylic acid transmembrane transporter activity#GO:0046943;L-amino acid transmembrane transporter activity#GO:0015179;amino acid transmembrane transporter activity#GO:0015171;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;neutral L-amino acid transmembrane transporter activity#GO:0015175 nitrogen compound transport#GO:0071705;L-amino acid transport#GO:0015807;cellular process#GO:0009987;carboxylic acid transport#GO:0046942;transport#GO:0006810;organic acid transport#GO:0015849;amino acid transport#GO:0006865;establishment of localization#GO:0051234;neutral amino acid transport#GO:0015804;transmembrane transport#GO:0055085;amino acid transmembrane transport#GO:0003333;localization#GO:0051179 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258;amino acid transporter#PC00046 HUMAN|HGNC=23614|UniProtKB=Q9NSC7 Q9NSC7 ST6GALNAC1 PTHR45941:SF1 ALPHA-N-ACETYLGALACTOSAMINIDE ALPHA-2,6-SIALYLTRANSFERASE 2-LIKE-RELATED ALPHA-N-ACETYLGALACTOSAMINIDE ALPHA-2,6-SIALYLTRANSFERASE 1 sialyltransferase activity#GO:0008373;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;transferase activity#GO:0016740 homeostasis of number of cells#GO:0048872;protein metabolic process#GO:0019538;oligosaccharide biosynthetic process#GO:0009312;primary metabolic process#GO:0044238;carbohydrate metabolic process#GO:0005975;biological process involved in interspecies interaction between organisms#GO:0044419;homeostatic process#GO:0042592;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;multicellular organismal-level homeostasis#GO:0048871;oligosaccharide metabolic process#GO:0009311;glycoprotein biosynthetic process#GO:0009101;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;multicellular organismal process#GO:0032501;carbohydrate biosynthetic process#GO:0016051;biosynthetic process#GO:0009058 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;membrane#GO:0016020;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139 HUMAN|HGNC=25186|UniProtKB=Q5SV17 Q5SV17 TMEM240 PTHR28666:SF1 TRANSMEMBRANE PROTEIN 240 TRANSMEMBRANE PROTEIN 240 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;synapse#GO:0045202;plasma membrane region#GO:0098590;synaptic membrane#GO:0097060;cell junction#GO:0030054 HUMAN|HGNC=25364|UniProtKB=Q9H0R4 Q9H0R4 HDHD2 PTHR19288:SF46 4-NITROPHENYLPHOSPHATASE-RELATED HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 2 phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 hydrolase#PC00121;phosphatase#PC00181 HUMAN|HGNC=28664|UniProtKB=Q5TAH2 Q5TAH2 SLC9C2 PTHR10110:SF91 SODIUM/HYDROGEN EXCHANGER SODIUM_HYDROGEN EXCHANGER 11 sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;metal cation:proton antiporter activity#GO:0051139;monoatomic ion transmembrane transporter activity#GO:0015075;secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;antiporter activity#GO:0015297;proton transmembrane transporter activity#GO:0015078;monoatomic cation transmembrane transporter activity#GO:0008324;potassium ion transmembrane transporter activity#GO:0015079 regulation of intracellular pH#GO:0051453;regulation of pH#GO:0006885;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;sodium ion transport#GO:0006814;intracellular monoatomic ion homeostasis#GO:0006873;inorganic ion import across plasma membrane#GO:0099587;homeostatic process#GO:0042592;metal ion transport#GO:0030001;import across plasma membrane#GO:0098739;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;chemical homeostasis#GO:0048878;transport#GO:0006810;inorganic cation import across plasma membrane#GO:0098659;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;import into cell#GO:0098657;establishment of localization#GO:0051234;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;monoatomic ion homeostasis#GO:0050801;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;potassium ion transport#GO:0006813 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258 HUMAN|HGNC=30748|UniProtKB=Q9UKU6 Q9UKU6 TRHDE PTHR11533:SF294 PROTEASE M1 ZINC METALLOPROTEASE THYROTROPIN-RELEASING HORMONE-DEGRADING ECTOENZYME catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;catalytic activity#GO:0003824;aminopeptidase activity#GO:0004177;metalloexopeptidase activity#GO:0008235;exopeptidase activity#GO:0008238;metalloaminopeptidase activity#GO:0070006;hydrolase activity#GO:0016787;metallopeptidase activity#GO:0008237 metabolic process#GO:0008152;proteolysis#GO:0006508;peptide metabolic process#GO:0006518;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;peptide catabolic process#GO:0043171;primary metabolic process#GO:0044238;catabolic process#GO:0009056 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 metalloprotease#PC00153;protease#PC00190 HUMAN|HGNC=17978|UniProtKB=Q96L58 Q96L58 B3GALT6 PTHR11214:SF410 BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE BETA-1,3-GALACTOSYLTRANSFERASE 6 catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758;glycosyltransferase activity#GO:0016757;catalytic activity, acting on a protein#GO:0140096;UDP-glycosyltransferase activity#GO:0008194;galactosyltransferase activity#GO:0008378 metabolic process#GO:0008152;aminoglycan metabolic process#GO:0006022;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;glycosaminoglycan biosynthetic process#GO:0006024;glycosaminoglycan metabolic process#GO:0030203;aminoglycan biosynthetic process#GO:0006023;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;biosynthetic process#GO:0009058 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 glycosyltransferase#PC00111;transferase#PC00220 HUMAN|HGNC=11088|UniProtKB=Q9H2G2 Q9H2G2 SLK PTHR48012:SF11 STERILE20-LIKE KINASE, ISOFORM B-RELATED STE20-LIKE SERINE_THREONINE-PROTEIN KINASE phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 regulation of cell migration#GO:0030334;regulation of apoptotic process#GO:0042981;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;regulation of cell motility#GO:2000145;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of programmed cell death#GO:0043067;signaling#GO:0023052;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=13544|UniProtKB=Q9NRG0 Q9NRG0 CHRAC1 PTHR10252:SF153 HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED CHROMATIN ACCESSIBILITY COMPLEX PROTEIN 1 cellular component organization#GO:0016043;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular process#GO:0009987;DNA replication#GO:0006260;chromatin remodeling#GO:0006338;chromatin organization#GO:0006325;nucleobase-containing compound metabolic process#GO:0006139;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;DNA-templated DNA replication#GO:0006261;macromolecule metabolic process#GO:0043170 nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;chromatin#GO:0000785;nucleus#GO:0005634;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ATPase complex#GO:1904949;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ISWI-type complex#GO:0031010;SWI/SNF superfamily-type complex#GO:0070603;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 DNA-binding transcription factor#PC00218 HUMAN|HGNC=19988|UniProtKB=Q9H1A4 Q9H1A4 ANAPC1 PTHR12827:SF3 MEIOTIC CHECKPOINT REGULATOR TSG24 FAMILY MEMBER ANAPHASE-PROMOTING COMPLEX SUBUNIT 1 regulation of cell cycle process#GO:0010564;protein ubiquitination#GO:0016567;proteasomal protein catabolic process#GO:0010498;cellular process#GO:0009987;metaphase/anaphase transition of cell cycle#GO:0044784;regulation of chromosome segregation#GO:0051983;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;regulation of cell cycle#GO:0051726;regulation of sister chromatid segregation#GO:0033045;regulation of cellular component organization#GO:0051128;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;regulation of biological process#GO:0050789;cell cycle process#GO:0022402;regulation of organelle organization#GO:0033043;protein K11-linked ubiquitination#GO:0070979;anaphase-promoting complex-dependent catabolic process#GO:0031145;protein catabolic process#GO:0030163;metaphase/anaphase transition of mitotic cell cycle#GO:0007091;modification-dependent macromolecule catabolic process#GO:0043632;protein modification by small protein conjugation or removal#GO:0070647;biological regulation#GO:0065007;post-translational protein modification#GO:0043687;mitotic cell cycle process#GO:1903047;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;regulation of chromosome organization#GO:0033044;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;mitotic cell cycle#GO:0000278;catabolic process#GO:0009056;cell cycle phase transition#GO:0044770;regulation of cellular process#GO:0050794;modification-dependent protein catabolic process#GO:0019941;cell cycle#GO:0007049;protein modification process#GO:0036211;primary metabolic process#GO:0044238;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;mitotic cell cycle phase transition#GO:0044772 ubiquitin ligase complex#GO:0000151;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;nuclear ubiquitin ligase complex#GO:0000152;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cullin-RING ubiquitin ligase complex#GO:0031461;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;protein-containing complex#GO:0032991;anaphase-promoting complex#GO:0005680;nucleus#GO:0005634 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=30268|UniProtKB=Q96AX2 Q96AX2 RAB37 PTHR47978:SF64 FAMILY NOT NAMED RAS-RELATED PROTEIN RAB-37 nucleoside phosphate binding#GO:1901265;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;guanyl nucleotide binding#GO:0019001;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;GTPase activity#GO:0003924;ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;hydrolase activity#GO:0016787;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111 regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transport#GO:0051049;regulation of localization#GO:0032879;regulation of exocytosis#GO:0017157;regulation of secretion by cell#GO:1903530;regulation of secretion#GO:0051046 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;endosome#GO:0005768 small GTPase#PC00208 HUMAN|HGNC=11444|UniProtKB=P61764 P61764 STXBP1 PTHR11679:SF35 VESICLE PROTEIN SORTING-ASSOCIATED SYNTAXIN-BINDING PROTEIN 1 protein binding#GO:0005515;syntaxin binding#GO:0019905;binding#GO:0005488;SNARE binding#GO:0000149 anterograde trans-synaptic signaling#GO:0098916;chemical synaptic transmission#GO:0007268;signal release from synapse#GO:0099643;localization#GO:0051179;cell communication#GO:0007154;secretion#GO:0046903;signal release#GO:0023061;trans-synaptic signaling#GO:0099537;organelle localization#GO:0051640;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;neurotransmitter secretion#GO:0007269;vesicle localization#GO:0051648;macromolecule localization#GO:0033036;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;synaptic vesicle cycle#GO:0099504;transport#GO:0006810;intracellular transport#GO:0046907;calcium-ion regulated exocytosis#GO:0017156;signaling#GO:0023052;export from cell#GO:0140352;establishment of organelle localization#GO:0051656;regulation of biological process#GO:0050789;secretion by cell#GO:0032940;protein transport#GO:0015031;cellular localization#GO:0051641;establishment of vesicle localization#GO:0051650;neurotransmitter transport#GO:0006836;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;synaptic vesicle exocytosis#GO:0016079;cellular process#GO:0009987;synaptic signaling#GO:0099536;exocytosis#GO:0006887;vesicle-mediated transport in synapse#GO:0099003;intracellular protein transport#GO:0006886;regulated exocytosis#GO:0045055 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;cytoplasm#GO:0005737;plasma membrane#GO:0005886;secretory vesicle#GO:0099503;membrane#GO:0016020;cell periphery#GO:0071944 membrane trafficking regulatory protein#PC00151 Synaptic vesicle trafficking#P05734>Munc18#P05770 HUMAN|HGNC=19824|UniProtKB=O95926 O95926 SYF2 PTHR13264:SF5 GCIP-INTERACTING PROTEIN P29 PRE-MRNA-SPLICING FACTOR SYF2 RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;RNA biosynthetic process#GO:0032774;mRNA cis splicing, via spliceosome#GO:0045292;mRNA metabolic process#GO:0016071;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396 nucleus#GO:0005634;post-mRNA release spliceosomal complex#GO:0071014;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ribonucleoprotein complex#GO:1990904;Prp19 complex#GO:0000974;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;catalytic step 2 spliceosome#GO:0071013;nuclear protein-containing complex#GO:0140513 HUMAN|HGNC=28007|UniProtKB=C9JLW8 C9JLW8 MCRIP1 PTHR48614:SF3 AT03386P MAPK-REGULATED COREPRESSOR-INTERACTING PROTEIN 1 HUMAN|HGNC=3390|UniProtKB=Q15375 Q15375 EPHA7 PTHR46877:SF9 EPH RECEPTOR A5 EPHRIN TYPE-A RECEPTOR 7 transmembrane signaling receptor activity#GO:0004888;phosphotransferase activity, alcohol group as acceptor#GO:0016773;molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714;protein kinase activity#GO:0004672;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein tyrosine kinase activity#GO:0004713;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;signaling receptor activity#GO:0038023;transmembrane receptor protein kinase activity#GO:0019199 ephrin receptor signaling pathway#GO:0048013;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;system development#GO:0048731;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;cell communication#GO:0007154;axon guidance#GO:0007411;axon development#GO:0061564;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;neurogenesis#GO:0022008;neuron projection guidance#GO:0097485;cellular developmental process#GO:0048869;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;cell development#GO:0048468;signaling#GO:0023052;cell morphogenesis#GO:0000902;cell differentiation#GO:0030154;response to stimulus#GO:0050896;cell projection organization#GO:0030030;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;axonogenesis#GO:0007409;neuron development#GO:0048666;cellular process#GO:0009987;signal transduction#GO:0007165;neuron projection development#GO:0031175;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell surface receptor signaling pathway#GO:0007166;neuron differentiation#GO:0030182;cell projection morphogenesis#GO:0048858;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275 cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;dendrite#GO:0030425;dendritic tree#GO:0097447 transmembrane signal receptor#PC00197 HUMAN|HGNC=21143|UniProtKB=O43167 O43167 ZBTB24 PTHR24404:SF95 ZINC FINGER PROTEIN ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 24 RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 DNA-binding transcription factor#PC00218;C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HUMAN|HGNC=7224|UniProtKB=P39210 P39210 MPV17 PTHR11266:SF128 PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17 MITOCHONDRIAL INNER MEMBRANE PROTEIN MPV17 channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 transporter#PC00227 HUMAN|HGNC=8661|UniProtKB=Q9HC56 Q9HC56 PCDH9 PTHR24028:SF248 CADHERIN-87A PROTOCADHERIN-9 cell adhesion#GO:0007155;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;glutamatergic synapse#GO:0098978;synapse#GO:0045202;cell junction#GO:0030054;plasma membrane#GO:0005886 cadherin#PC00057;cell adhesion molecule#PC00069 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HUMAN|HGNC=37278|UniProtKB=B0FP48 B0FP48 UPK3BL1 PTHR15446:SF2 UROPLAKIN III UROPLAKIN-3B-LIKE PROTEIN 1-RELATED membrane#GO:0016020;cellular anatomical structure#GO:0110165 HUMAN|HGNC=10548|UniProtKB=P54253 P54253 ATXN1 PTHR13392:SF5 ATAXIN 1 ATAXIN-1 chromatin binding#GO:0003682;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;central nervous system development#GO:0007417;animal gross anatomical part developmental process#GO:0160108;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of macromolecule biosynthetic process#GO:0010558;nervous system development#GO:0007399;head development#GO:0060322;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;animal organ development#GO:0048513;multicellular organism development#GO:0007275;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;negative regulation of transcription by RNA polymerase II#GO:0000122;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;brain development#GO:0007420;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=17429|UniProtKB=Q9P2M7 Q9P2M7 CGN PTHR46349:SF4 CINGULIN-LIKE PROTEIN 1-RELATED CINGULIN binding#GO:0005488;microtubule binding#GO:0008017;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515 cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;microtubule-based process#GO:0007017;cytoskeleton organization#GO:0007010;microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840 anchoring junction#GO:0070161;cellular anatomical structure#GO:0110165;tight junction#GO:0070160;bicellular tight junction#GO:0005923;cell junction#GO:0030054;cell-cell junction#GO:0005911;apical junction complex#GO:0043296 HUMAN|HGNC=14971|UniProtKB=Q9UNH6 Q9UNH6 SNX7 PTHR45949:SF3 SORTING NEXIN-4 SORTING NEXIN-7 vesicle-mediated transport#GO:0016192;macroautophagy#GO:0016236;macromolecule localization#GO:0033036;reticulophagy#GO:0061709;establishment of protein localization#GO:0045184;autophagy#GO:0006914;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;mitophagy#GO:0000423;establishment of localization#GO:0051234;endosomal transport#GO:0016197;vesicle-mediated transport to the plasma membrane#GO:0098876;intracellular protein localization#GO:0008104;metabolic process#GO:0008152;autophagy of mitochondrion#GO:0000422;intracellular transport#GO:0046907;transport#GO:0006810;endocytic recycling#GO:0032456;catabolic process#GO:0009056;piecemeal microautophagy of the nucleus#GO:0034727;localization#GO:0051179;cellular localization#GO:0051641;protein transport#GO:0015031;process utilizing autophagic mechanism#GO:0061919;localization within membrane#GO:0051668 phagophore assembly site#GO:0000407;intracellular organelle#GO:0043229;endosome#GO:0005768;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 scaffold/adaptor protein#PC00226 HUMAN|HGNC=8909|UniProtKB=A6NDG6 A6NDG6 PGP PTHR19288:SF92 4-NITROPHENYLPHOSPHATASE-RELATED PHOSPHOGLYCOLATE PHOSPHATASE catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 hydrolase#PC00121;phosphatase#PC00181 HUMAN|HGNC=15897|UniProtKB=Q5TEA6 Q5TEA6 SEL1L2 PTHR11102:SF53 SEL-1-LIKE PROTEIN PROTEIN SEL-1 HOMOLOG 2 metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;response to stress#GO:0006950;cellular process#GO:0009987;response to chemical#GO:0042221;proteasomal protein catabolic process#GO:0010498;response to endoplasmic reticulum stress#GO:0034976;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;protein metabolic process#GO:0019538;ERAD pathway#GO:0036503;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;catabolic process#GO:0009056 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;membrane#GO:0016020;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 HUMAN|HGNC=18601|UniProtKB=Q9BZR6 Q9BZR6 RTN4R PTHR24369:SF174 ANTIGEN BSP, PUTATIVE-RELATED RETICULON-4 RECEPTOR ion binding#GO:0043167;anion binding#GO:0043168;binding#GO:0005488;carboxylic acid binding#GO:0031406;small molecule binding#GO:0036094;organic acid binding#GO:0043177;lipid binding#GO:0008289;carbohydrate derivative binding#GO:0097367 regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;positive regulation of signaling#GO:0023056;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of Rho protein signal transduction#GO:0035023;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;regulation of small GTPase mediated signal transduction#GO:0051056;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584 cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;plasma membrane#GO:0005886;membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944 cell adhesion molecule#PC00069 HUMAN|HGNC=28989|UniProtKB=Q92617 Q92617 NPIPB3 PTHR15438:SF5 NUCLEAR PORE COMPLEX INTERACTING PROTEIN NUCLEAR PORE COMPLEX INTERACTING PROTEIN FAMILY MEMBER B3-RELATED HUMAN|HGNC=12897|UniProtKB=Q03924 Q03924 ZNF117 PTHR24384:SF120 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED ZINC FINGER PROTEIN 117 transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218 HUMAN|HGNC=26208|UniProtKB=Q9H649 Q9H649 NSUN3 PTHR22808:SF8 NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING TRNA (CYTOSINE(34)-C(5))-METHYLTRANSFERASE, MITOCHONDRIAL tRNA methyltransferase activity#GO:0008175;catalytic activity, acting on RNA#GO:0140098;RNA methyltransferase activity#GO:0008173;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a tRNA#GO:0140101;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757 metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;cellular process#GO:0009987;tRNA methylation#GO:0030488;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;macromolecule methylation#GO:0043414;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;RNA methylation#GO:0001510;methylation#GO:0032259;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;tRNA wobble base modification#GO:0002097;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;tRNA modification#GO:0006400 mitochondrion#GO:0005739;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 RNA methyltransferase#PC00033 HUMAN|HGNC=23790|UniProtKB=Q96FX7 Q96FX7 TRMT61A PTHR12133:SF2 TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE CATALYTIC SUBUNIT TRMT61A catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on RNA#GO:0140098;RNA methyltransferase activity#GO:0008173;tRNA methyltransferase activity#GO:0008175;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;catalytic activity, acting on a tRNA#GO:0140101 metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;tRNA methylation#GO:0030488;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;macromolecule methylation#GO:0043414;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;macromolecule modification#GO:0043412;methylation#GO:0032259;RNA metabolic process#GO:0016070;RNA methylation#GO:0001510;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;tRNA modification#GO:0006400 intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;methyltransferase complex#GO:0034708;transferase complex#GO:1990234;catalytic complex#GO:1902494 RNA methyltransferase#PC00033;RNA metabolism protein#PC00031 HUMAN|HGNC=8226|UniProtKB=A0A286YEU6 A0A286YEU6 OR1R1 PTHR26451:SF196 G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN OLFACTORY RECEPTOR 1R1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception#GO:0007600;nervous system process#GO:0050877;system process#GO:0003008;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;detection of chemical stimulus#GO:0009593;response to chemical#GO:0042221;response to stimulus#GO:0050896;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608 membrane#GO:0016020;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021 HUMAN|HGNC=28762|UniProtKB=Q9BVQ7 Q9BVQ7 AFG2B PTHR23077:SF117 AAA-FAMILY ATPASE ATPASE FAMILY GENE 2 PROTEIN HOMOLOG B catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP-dependent activity#GO:0140657;hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887 transporter#PC00227;primary active transporter#PC00068 HUMAN|HGNC=2157|UniProtKB=Q15417 Q15417 CNN3 PTHR47385:SF17 CALPONIN CALPONIN-3 binding#GO:0005488;actin filament binding#GO:0051015;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877 cellular component organization or biogenesis#GO:0071840;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;actin filament-based process#GO:0030029;actin cytoskeleton organization#GO:0030036;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165;actin cytoskeleton#GO:0015629 HUMAN|HGNC=37234|UniProtKB=Q9H6L2 Q9H6L2 TMEM231 PTHR14605:SF1 CHST5 PROTEIN TRANSMEMBRANE PROTEIN 231 cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component organization or biogenesis#GO:0071840;regulation of localization#GO:0032879;plasma membrane bounded cell projection assembly#GO:0120031;cell projection organization#GO:0030030;cilium assembly#GO:0060271;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;cilium organization#GO:0044782;regulation of protein localization#GO:0032880;organelle assembly#GO:0070925 plasma membrane bounded cell projection#GO:0120025;ciliary membrane#GO:0060170;cell projection#GO:0042995;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane region#GO:0098590;cell periphery#GO:0071944;membrane#GO:0016020;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;cell projection membrane#GO:0031253;cilium#GO:0005929;ciliary transition zone#GO:0035869 HUMAN|HGNC=24528|UniProtKB=Q9NZ81 Q9NZ81 PRR13 PTHR36287:SF1 FAMILY NOT NAMED PROLINE-RICH PROTEIN 13 cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 HUMAN|HGNC=1727|UniProtKB=P30307 P30307 CDC25C PTHR10828:SF64 M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25 M-PHASE INDUCER PHOSPHATASE 3 hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725;phosphoprotein phosphatase activity#GO:0004721;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791 regulation of cell cycle#GO:0051726;regulation of cellular process#GO:0050794;cell cycle phase transition#GO:0044770;G2/M transition of mitotic cell cycle#GO:0000086;mitotic cell cycle#GO:0000278;cell cycle process#GO:0022402;positive regulation of cell cycle process#GO:0090068;regulation of biological process#GO:0050789;regulation of meiotic cell cycle#GO:0051445;regulation of cell cycle phase transition#GO:1901987;cell cycle#GO:0007049;regulation of mitotic cell cycle phase transition#GO:1901990;regulation of G2/M transition of mitotic cell cycle#GO:0010389;mitotic cell cycle phase transition#GO:0044772;positive regulation of cell cycle#GO:0045787;regulation of cell cycle process#GO:0010564;biological regulation#GO:0065007;regulation of reproductive process#GO:2000241;regulation of mitotic cell cycle#GO:0007346;cellular process#GO:0009987;cell cycle G2/M phase transition#GO:0044839;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of cell cycle G2/M phase transition#GO:1902749;positive regulation of mitotic cell cycle#GO:0045931;mitotic cell cycle process#GO:1903047 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 protein phosphatase#PC00195;protein modifying enzyme#PC00260 p53 pathway#P00059>Cdc25C#P04624 HUMAN|HGNC=23915|UniProtKB=P0C7P1 P0C7P1 RBMY1D PTHR48034:SF17 TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED RNA-BINDING MOTIF PROTEIN, Y CHROMOSOME, FAMILY 1 MEMBER A1-RELATED binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723 RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634;spliceosomal complex#GO:0005681;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904 RNA metabolism protein#PC00031 HUMAN|HGNC=23020|UniProtKB=Q8WU68 Q8WU68 U2AF1L4 PTHR12620:SF3 U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT SPLICING FACTOR U2AF 26 KDA SUBUNIT RNA binding#GO:0003723;nucleic acid binding#GO:0003676;pre-mRNA binding#GO:0036002;binding#GO:0005488 mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;mRNA splicing, via spliceosome#GO:0000398;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226 RNA splicing factor#PC00148 HUMAN|HGNC=7234|UniProtKB=Q96E11 Q96E11 MRRF PTHR20982:SF10 RIBOSOME RECYCLING FACTOR RIBOSOME-RECYCLING FACTOR, MITOCHONDRIAL ribosome binding#GO:0043022;protein-containing complex binding#GO:0044877;ribosomal large subunit binding#GO:0043023;ribonucleoprotein complex binding#GO:0043021;binding#GO:0005488 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;organelle organization#GO:0006996;biosynthetic process#GO:0009058;gene expression#GO:0010467;metabolic process#GO:0008152;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;protein-containing complex disassembly#GO:0032984;protein biosynthetic process#GO:0160307;mitochondrial translation#GO:0032543;translation#GO:0006412;translational termination#GO:0006415;mitochondrial gene expression#GO:0140053;protein metabolic process#GO:0019538;cellular component disassembly#GO:0022411;organelle disassembly#GO:1903008 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 translation release factor#PC00225 HUMAN|HGNC=11002|UniProtKB=O43868 O43868 SLC28A2 PTHR10590:SF11 SODIUM/NUCLEOSIDE COTRANSPORTER SODIUM_NUCLEOSIDE COTRANSPORTER 2 symporter activity#GO:0015293;solute:sodium symporter activity#GO:0015370;nucleobase-containing compound transmembrane transporter activity#GO:0015932;monoatomic cation transmembrane transporter activity#GO:0008324;carbohydrate derivative transmembrane transporter activity#GO:1901505;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;solute:monoatomic cation symporter activity#GO:0015294;monoatomic ion transmembrane transporter activity#GO:0015075;nucleoside transmembrane transporter activity#GO:0005337;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873 transport#GO:0006810;tissue homeostasis#GO:0001894;multicellular organismal-level homeostasis#GO:0048871;localization#GO:0051179;retina homeostasis#GO:0001895;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;cellular process#GO:0009987;carbohydrate derivative transport#GO:1901264;nitrogen compound transport#GO:0071705;homeostatic process#GO:0042592;nucleobase-containing compound transport#GO:0015931;anatomical structure homeostasis#GO:0060249;multicellular organismal process#GO:0032501 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227 HUMAN|HGNC=30800|UniProtKB=Q8NEW7 Q8NEW7 TMIE PTHR28635:SF1 TRANSMEMBRANE INNER EAR EXPRESSED PROTEIN TRANSMEMBRANE INNER EAR EXPRESSED PROTEIN ear development#GO:0043583;anatomical structure development#GO:0048856;sensory perception#GO:0007600;sensory perception of mechanical stimulus#GO:0050954;nervous system process#GO:0050877;embryonic organ development#GO:0048568;animal gross anatomical part developmental process#GO:0160108;sensory perception of sound#GO:0007605;animal organ morphogenesis#GO:0009887;sensory organ morphogenesis#GO:0090596;anatomical structure morphogenesis#GO:0009653;system process#GO:0003008;embryonic morphogenesis#GO:0048598;multicellular organism development#GO:0007275;animal organ development#GO:0048513;developmental process#GO:0032502;sensory organ development#GO:0007423;embryo development#GO:0009790;multicellular organismal process#GO:0032501;inner ear morphogenesis#GO:0042472;inner ear development#GO:0048839 HUMAN|HGNC=9065|UniProtKB=P19174 P19174 PLCG1 PTHR10336:SF173 PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN 1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1 hydrolase activity#GO:0016787;lipase activity#GO:0016298;phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578;catalytic activity#GO:0003824;glycerophospholipase activity#GO:0004620;phospholipase activity#GO:0120569;hydrolase activity, acting on ester bonds#GO:0016788 metal ion transport#GO:0030001;phospholipid metabolic process#GO:0006644;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;intracellular signal transduction#GO:0035556;regulation of cell motility#GO:2000145;localization#GO:0051179;cell communication#GO:0007154;monoatomic cation transport#GO:0006812;regulation of locomotion#GO:0040012;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;positive regulation of cell migration#GO:0030335;positive regulation of cellular process#GO:0048522;organophosphate metabolic process#GO:0019637;positive regulation of locomotion#GO:0040017;establishment of localization#GO:0051234;lipid metabolic process#GO:0006629;phosphatidylinositol metabolic process#GO:0046488;transport#GO:0006810;regulation of cell migration#GO:0030334;signaling#GO:0023052;glycerolipid metabolic process#GO:0046486;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;phosphorus metabolic process#GO:0006793;calcium ion transmembrane transport#GO:0070588;positive regulation of cell motility#GO:2000147;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;regulation of multicellular organismal process#GO:0051239;monoatomic cation transmembrane transport#GO:0098655;glycerophospholipid metabolic process#GO:0006650;cellular process#GO:0009987;release of sequestered calcium ion into cytosol#GO:0051209;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;calcium ion transport#GO:0006816;calcium ion transmembrane import into cytosol#GO:0097553;metabolic process#GO:0008152 cell projection membrane#GO:0031253;ruffle#GO:0001726;ruffle membrane#GO:0032587;leading edge membrane#GO:0031256;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane#GO:0005886;plasma membrane bounded cell projection#GO:0120025;cell leading edge#GO:0031252;membrane#GO:0016020;cell periphery#GO:0071944 hydrolase#PC00121;metabolite interconversion enzyme#PC00262;phospholipase#PC00186;lipase#PC00143 5HT2 type receptor mediated signaling pathway#P04374>PLC#P04412;PDGF signaling pathway#P00047>PLCgamma#P01171;Histamine H1 receptor mediated signaling pathway#P04385>PLC#P04484;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PLCbetagamma#P00874;EGF receptor signaling pathway#P00018>PLCgamma#P00556;Axon guidance mediated by netrin#P00009>Phospholipase C#P00362;Oxytocin receptor mediated signaling pathway#P04391>PLC beta#P04530;FGF signaling pathway#P00021>PLCgamma#P00638;Thyrotropin-releasing hormone receptor signaling pathway#P04394>PLC#P04581;Angiogenesis#P00005>PLC-gamma#P00256;CCKR signaling map#P06959>PLCgamma1#P07037;T cell activation#P00053>PLC-gamma#P01320;VEGF signaling pathway#P00056>PLC-gamma#P01414 HUMAN|HGNC=28746|UniProtKB=Q8IVP5 Q8IVP5 FUNDC1 PTHR21346:SF2 FUN14 DOMAIN CONTAINING FUN14 DOMAIN-CONTAINING PROTEIN 1 cellular process#GO:0009987;autophagy#GO:0006914;autophagy of mitochondrion#GO:0000422;metabolic process#GO:0008152;process utilizing autophagic mechanism#GO:0061919;catabolic process#GO:0009056 bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;mitochondrial outer membrane#GO:0005741;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;membrane#GO:0016020;cytoplasm#GO:0005737;organelle outer membrane#GO:0031968;outer membrane#GO:0019867;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=24682|UniProtKB=Q9Y5Y0 Q9Y5Y0 FLVCR1 PTHR10924:SF2 MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED CHOLINE_ETHANOLAMINE TRANSPORTER FLVCR1 tetrapyrrole binding#GO:0046906;heme binding#GO:0020037;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;binding#GO:0005488 transition metal ion transport#GO:0000041;iron ion transport#GO:0006826;homeostasis of number of cells#GO:0048872;immune system process#GO:0002376;monoatomic ion transport#GO:0006811;anatomical structure development#GO:0048856;cellular localization#GO:0051641;erythrocyte differentiation#GO:0030218;monoatomic cation transport#GO:0006812;localization#GO:0051179;cell development#GO:0048468;metal ion transport#GO:0030001;homeostatic process#GO:0042592;myeloid cell differentiation#GO:0030099;cell differentiation#GO:0030154;mitochondrial transport#GO:0006839;transport#GO:0006810;developmental process#GO:0032502;intracellular transport#GO:0046907;iron coordination entity transport#GO:1901678;multicellular organismal-level homeostasis#GO:0048871;cellular developmental process#GO:0048869;establishment of localization#GO:0051234;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;nitrogen compound transport#GO:0071705;hemopoiesis#GO:0030097;multicellular organismal process#GO:0032501 membrane#GO:0016020;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 secondary carrier transporter#PC00258 HUMAN|HGNC=19306|UniProtKB=Q8NEW0 Q8NEW0 SLC30A7 PTHR45755:SF6 FAMILY NOT NAMED ZINC TRANSPORTER 7 transition metal ion transmembrane transporter activity#GO:0046915;zinc ion transmembrane transporter activity#GO:0005385;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation transmembrane transporter activity#GO:0008324;metal ion transmembrane transporter activity#GO:0046873 zinc ion transmembrane transport#GO:0071577;transition metal ion transport#GO:0000041;inorganic ion homeostasis#GO:0098771;monoatomic ion transport#GO:0006811;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;intracellular monoatomic ion homeostasis#GO:0006873;homeostatic process#GO:0042592;metal ion transport#GO:0030001;intracellular monoatomic cation homeostasis#GO:0030003;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;establishment of localization#GO:0051234;cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;zinc ion transport#GO:0006829 intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;Golgi stack#GO:0005795;organelle membrane#GO:0031090;Golgi apparatus#GO:0005794;endomembrane system#GO:0012505;Golgi cisterna#GO:0031985;cytoplasm#GO:0005737;Golgi cis cisterna#GO:0000137;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791 HUMAN|HGNC=16348|UniProtKB=Q8IWW6 Q8IWW6 ARHGAP12 PTHR23176:SF107 RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN RHO GTPASE-ACTIVATING PROTEIN 12 nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;signaling#GO:0023052;intracellular signaling cassette#GO:0141124;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 GTPase-activating protein#PC00257 PDGF signaling pathway#P00047>Rho#P01174 HUMAN|HGNC=20960|UniProtKB=Q6P5S2 Q6P5S2 LEG1 PTHR18820:SF1 LEG1 PROTEIN LEG1 HOMOLOG extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=4410|UniProtKB=O60262 O60262 GNG7 PTHR13809:SF8 GUANINE NUCLEOTIDE-BINDING PROTEIN GAMMA SUBUNIT GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)_G(S)_G(O) SUBUNIT GAMMA-7 hydrolase activity#GO:0016787;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;molecular function regulator activity#GO:0098772;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane protein complex#GO:0098796;cytoplasmic side of plasma membrane#GO:0009898;membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;extrinsic component of membrane#GO:0019898;side of membrane#GO:0098552;extrinsic component of plasma membrane#GO:0019897;catalytic complex#GO:1902494;extrinsic component of cytoplasmic side of plasma membrane#GO:0031234;cytoplasmic side of membrane#GO:0098562 heterotrimeric G-protein#PC00117 Opioid proopiomelanocortin pathway#P05917>G-protein#P06012;Metabotropic glutamate receptor group III pathway#P00039>G-Protein#P01045;5HT4 type receptor mediated signaling pathway#P04376>G-protein#P04430;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>G-Protein#P01073;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>G-Protein#P01085;Oxytocin receptor mediated signaling pathway#P04391>G-Protein#P04534;Cortocotropin releasing factor receptor signaling pathway#P04380>G-Protein#P04458;5HT2 type receptor mediated signaling pathway#P04374>G-protein#P04416;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Ggamma#P00751;Thyrotropin-releasing hormone receptor signaling pathway#P04394>G-Protein#P04584;Enkephalin release#P05913>G-Protein (s)#P05977;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Gbetagamma#P00836;Angiotensin II-stimulated signaling through G proteins and beta-arrestin#P05911>Ggamma#P05929;Enkephalin release#P05913>G-Protein (i)#P05974;Beta2 adrenergic receptor signaling pathway#P04378>G-Protein#P04443;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Ggamma#P00721;Histamine H2 receptor mediated signaling pathway#P04386>G-Protein#P04490;5HT1 type receptor mediated signaling pathway#P04373>G-protein#P04408;GABA-B receptor II signaling#P05731>Ggamma#P05754;Histamine H1 receptor mediated signaling pathway#P04385>G-Protein#P04488;Opioid proenkephalin pathway#P05915>G-protein#P05994;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Ggamma#P00726;Metabotropic glutamate receptor group II pathway#P00040>G-protein#P01047;Beta3 adrenergic receptor signaling pathway#P04379>G-Protein#P04448;Beta1 adrenergic receptor signaling pathway#P04377>G-Protein#P04436;Opioid prodynorphin pathway#P05916>G-protein#P06002;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GIRK#P00743;Endogenous cannabinoid signaling#P05730>Ggamma#P05744;Wnt signaling pathway#P00057>Ggamma#P01465 HUMAN|HGNC=11898|UniProtKB=P98066 P98066 TNFAIP6 PTHR46908:SF10 CUBILIN-LIKE PROTEIN TUMOR NECROSIS FACTOR-INDUCIBLE GENE 6 PROTEIN regulation of response to stress#GO:0080134;regulation of defense response#GO:0031347;regulation of response to stimulus#GO:0048583;regulation of inflammatory response#GO:0050727;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of response to stimulus#GO:0048585;regulation of response to external stimulus#GO:0032101;negative regulation of inflammatory response#GO:0050728;negative regulation of defense response#GO:0031348;biological regulation#GO:0065007;negative regulation of response to external stimulus#GO:0032102 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=4496|UniProtKB=O43194 O43194 GPR39 PTHR46752:SF1 G-PROTEIN COUPLED RECEPTOR 39 G PROTEIN-COUPLED RECEPTOR 39 transmembrane signaling receptor activity#GO:0004888;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 intracellular chemical homeostasis#GO:0055082;regulation of biological quality#GO:0065008;cellular homeostasis#GO:0019725;regulation of intracellular pH#GO:0051453;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;regulation of pH#GO:0006885;biological regulation#GO:0065007;homeostatic process#GO:0042592;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion homeostasis#GO:0050801 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=24811|UniProtKB=Q14554 Q14554 PDIA5 PTHR45672:SF2 PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED PROTEIN DISULFIDE-ISOMERASE A5 isomerase activity#GO:0016853;catalytic activity, acting on a protein#GO:0140096;intramolecular oxidoreductase activity#GO:0016860;protein disulfide isomerase activity#GO:0003756;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;biosynthetic process#GO:0009058;protein folding#GO:0006457;protein maturation#GO:0051604;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 chaperone#PC00072 HUMAN|HGNC=22225|UniProtKB=Q96JN2 Q96JN2 CCDC136 PTHR15715:SF26 CENTROSOMAL PROTEIN OF 170 KDA COILED-COIL DOMAIN-CONTAINING PROTEIN 136 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 cellular component assembly#GO:0022607;endomembrane system organization#GO:0010256;negative regulation of signal transduction#GO:0009968;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;single fertilization#GO:0007338;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;anatomical structure formation involved in morphogenesis#GO:0048646;vesicle organization#GO:0016050;cellular anatomical entity morphogenesis#GO:0032989;cell differentiation#GO:0030154;gamete generation#GO:0007276;cellular process involved in reproduction in multicellular organism#GO:0022412;cell development#GO:0048468;fertilization#GO:0009566;regulation of hippo signaling#GO:0035330;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of hippo signaling#GO:0035331;negative regulation of cell communication#GO:0010648;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;spermatid differentiation#GO:0048515;acrosome assembly#GO:0001675;regulation of signaling#GO:0023051;male gamete generation#GO:0048232;negative regulation of response to stimulus#GO:0048585;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;cellular developmental process#GO:0048869;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;spermatogenesis#GO:0007283;regulation of response to stimulus#GO:0048583;regulation of cellular process#GO:0050794;reproductive process#GO:0022414;regulation of cell communication#GO:0010646;developmental process involved in reproduction#GO:0003006;germ cell development#GO:0007281;anatomical structure development#GO:0048856;multicellular organismal reproductive process#GO:0048609;organelle assembly#GO:0070925;cellular component assembly involved in morphogenesis#GO:0010927;sexual reproduction#GO:0019953;spermatid development#GO:0007286 cytoplasm#GO:0005737;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;secretory vesicle#GO:0099503;membrane#GO:0016020;vesicle membrane#GO:0012506;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;acrosomal membrane#GO:0002080;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular vesicle#GO:0097708;secretory granule membrane#GO:0030667;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;acrosomal vesicle#GO:0001669 scaffold/adaptor protein#PC00226 HUMAN|HGNC=15920|UniProtKB=Q9Y6I8 Q9Y6I8 PXMP4 PTHR15460:SF3 PEROXISOMAL MEMBRANE PROTEIN 4 PEROXISOMAL MEMBRANE PROTEIN 4 bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;peroxisomal membrane#GO:0005778;organelle#GO:0043226;microbody#GO:0042579;membrane#GO:0016020;peroxisome#GO:0005777 HUMAN|HGNC=9472|UniProtKB=Q99538 Q99538 LGMN PTHR12000:SF38 HEMOGLOBINASE FAMILY MEMBER LEGUMAIN cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;cysteine-type endopeptidase activity#GO:0004197;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233 metabolic process#GO:0008152;proteolysis#GO:0006508;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;protein processing#GO:0016485;cellular process#GO:0009987;catabolic process#GO:0009056;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;lytic vacuole#GO:0000323;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;lysosome#GO:0005764;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vacuole#GO:0005773;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 cysteine protease#PC00081;protein modifying enzyme#PC00260;protease#PC00190 HUMAN|HGNC=5925|UniProtKB=A0A075B6I7 A0A075B6I7 IGLV5-48 PTHR23267:SF325 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN LAMBDA VARIABLE 5-37-RELATED immune system process#GO:0002376;immune response#GO:0006955;response to stimulus#GO:0050896 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=13745|UniProtKB=Q9BTV5 Q9BTV5 FSD1 PTHR24099:SF4 E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED FIBRONECTIN TYPE III AND SPRY DOMAIN-CONTAINING PROTEIN 1 protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;microtubule binding#GO:0008017;binding#GO:0005488 regulation of microtubule-based process#GO:0032886;regulation of cell division#GO:0051302;regulation of mitotic spindle organization#GO:0060236;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of microtubule cytoskeleton organization#GO:0070507;regulation of cell cycle#GO:0051726;regulation of cell cycle process#GO:0010564;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;regulation of spindle organization#GO:0090224 supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;supramolecular complex#GO:0099080;organelle#GO:0043226;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;microtubule cytoskeleton#GO:0015630 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=2847|UniProtKB=Q8WYQ5 Q8WYQ5 DGCR8 PTHR13482:SF3 MICRORNA PROCESSOR COMPLEX SUBUNIT DGCR8 MICROPROCESSOR COMPLEX SUBUNIT DGCR8 RNA binding#GO:0003723;double-stranded RNA binding#GO:0003725;binding#GO:0005488;nucleic acid binding#GO:0003676 negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;primary miRNA processing#GO:0031053;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of metabolic process#GO:0009892;nucleic acid biosynthetic process#GO:0141187;miRNA processing#GO:0035196;RNA metabolic process#GO:0016070;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;macromolecule biosynthetic process#GO:0009059;negative regulation of macromolecule metabolic process#GO:0010605;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;biosynthetic process#GO:0009058;negative regulation of cellular process#GO:0048523;regulatory ncRNA-mediated gene silencing#GO:0031047;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulatory ncRNA processing#GO:0070918;regulation of gene expression#GO:0010468;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;RNA biosynthetic process#GO:0032774 catalytic complex#GO:1902494;intracellular organelle#GO:0043229;endoribonuclease complex#GO:1902555;endonuclease complex#GO:1905348;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226 RNA processing factor#PC00147 HUMAN|HGNC=18075|UniProtKB=Q9NZD4 Q9NZD4 AHSP PTHR15914:SF0 ALPHA-HEMOGLOBIN-STABILIZING PROTEIN ALPHA-HEMOGLOBIN-STABILIZING PROTEIN protein stabilization#GO:0050821;multicellular organismal-level homeostasis#GO:0048871;macromolecule metabolic process#GO:0043170;cellular developmental process#GO:0048869;developmental process#GO:0032502;metabolic process#GO:0008152;biological regulation#GO:0065007;biosynthetic process#GO:0009058;hemopoiesis#GO:0030097;protein maturation#GO:0051604;gene expression#GO:0010467;multicellular organismal process#GO:0032501;regulation of protein stability#GO:0031647;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;regulation of biological quality#GO:0065008;erythrocyte differentiation#GO:0030218;protein metabolic process#GO:0019538;anatomical structure development#GO:0048856;homeostasis of number of cells#GO:0048872;immune system process#GO:0002376;homeostatic process#GO:0042592;cell development#GO:0048468;protein folding#GO:0006457;cell differentiation#GO:0030154;myeloid cell differentiation#GO:0030099;primary metabolic process#GO:0044238 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HUMAN|HGNC=11427|UniProtKB=Q9UNE7 Q9UNE7 STUB1 PTHR46803:SF5 E3 UBIQUITIN-PROTEIN LIGASE CHIP E3 UBIQUITIN-PROTEIN LIGASE CHIP protein binding#GO:0005515;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;binding#GO:0005488;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein-folding chaperone binding#GO:0051087 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;protein quality control for misfolded or incompletely synthesized proteins#GO:0006515;primary metabolic process#GO:0044238;protein modification process#GO:0036211;cellular response to stimulus#GO:0051716;modification-dependent protein catabolic process#GO:0019941;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;cellular response to topologically incorrect protein#GO:0035967;post-translational protein modification#GO:0043687;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;cellular response to misfolded protein#GO:0071218;response to stimulus#GO:0050896;response to topologically incorrect protein#GO:0035966;response to misfolded protein#GO:0051788;regulation of biological process#GO:0050789;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;positive regulation of metabolic process#GO:0009893;protein modification by small protein conjugation or removal#GO:0070647;modification-dependent macromolecule catabolic process#GO:0043632;positive regulation of protein metabolic process#GO:0051247;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;positive regulation of macromolecule metabolic process#GO:0010604;proteasomal protein catabolic process#GO:0010498;protein ubiquitination#GO:0016567;regulation of protein metabolic process#GO:0051246;response to stress#GO:0006950;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;regulation of proteolysis#GO:0030162 contractile muscle fiber#GO:0043292;Z disc#GO:0030018;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;I band#GO:0031674;intracellular organelle#GO:0043229;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;sarcomere#GO:0030017;myofibril#GO:0030016;membraneless organelle#GO:0043228 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 Parkinson disease#P00049>CHIP#P01214 HUMAN|HGNC=18901|UniProtKB=Q9HCY8 Q9HCY8 S100A14 PTHR11639:SF4 S100 CALCIUM-BINDING PROTEIN PROTEIN S100-A14 G protein-coupled receptor binding#GO:0001664;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;signaling receptor binding#GO:0005102;binding#GO:0005488;cytokine receptor binding#GO:0005126;cation binding#GO:0043169;protein binding#GO:0005515;chemokine receptor binding#GO:0042379;metal ion binding#GO:0046872 immune response-regulating signaling pathway#GO:0002764;regulation of biological process#GO:0050789;response to molecule of bacterial origin#GO:0002237;regulation of chemotaxis#GO:0050920;positive regulation of cell motility#GO:2000147;biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052;response to stimulus#GO:0050896;response to oxygen-containing compound#GO:1901700;immune system process#GO:0002376;cellular process#GO:0009987;activation of immune response#GO:0002253;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of immune system process#GO:0002684;response to biotic stimulus#GO:0009607;response to lipid#GO:0033993;regulation of response to external stimulus#GO:0032101;response to chemical#GO:0042221;cell surface receptor signaling pathway#GO:0007166;response to lipopolysaccharide#GO:0032496;positive regulation of response to external stimulus#GO:0032103;immune response-activating signaling pathway#GO:0002757;cellular response to stimulus#GO:0051716;innate immune response-activating signaling pathway#GO:0002758;immune response-activating cell surface receptor signaling pathway#GO:0002429;regulation of response to biotic stimulus#GO:0002831;response to external biotic stimulus#GO:0043207;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of leukocyte migration#GO:0002685;regulation of defense response#GO:0031347;regulation of granulocyte chemotaxis#GO:0071622;regulation of immune response#GO:0050776;response to bacterium#GO:0009617;positive regulation of chemotaxis#GO:0050921;cell communication#GO:0007154;regulation of cell motility#GO:2000145;positive regulation of cell migration#GO:0030335;positive regulation of innate immune response#GO:0045089;positive regulation of cellular process#GO:0048522;activation of innate immune response#GO:0002218;regulation of locomotion#GO:0040012;response to other organism#GO:0051707;immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007;toll-like receptor 4 signaling pathway#GO:0034142;positive regulation of response to stimulus#GO:0048584;regulation of response to stimulus#GO:0048583;positive regulation of defense response#GO:0031349;positive regulation of immune response#GO:0050778;regulation of cell migration#GO:0030334;regulation of response to stress#GO:0080134;pattern recognition receptor signaling pathway#GO:0002221;positive regulation of response to biotic stimulus#GO:0002833;response to external stimulus#GO:0009605;positive regulation of locomotion#GO:0040017;regulation of innate immune response#GO:0045088 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165;perinuclear region of cytoplasm#GO:0048471;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 calmodulin-related#PC00061;calcium-binding protein#PC00060 HUMAN|HGNC=1850|UniProtKB=Q9NYQ6 Q9NYQ6 CELSR1 PTHR24026:SF36 FAT ATYPICAL CADHERIN-RELATED CADHERIN EGF LAG SEVEN-PASS G-TYPE RECEPTOR 1 anatomical structure development#GO:0048856;axonogenesis#GO:0007409;neuron development#GO:0048666;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;cell adhesion#GO:0007155;generation of neurons#GO:0048699;cell morphogenesis#GO:0000902;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell development#GO:0048468;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;neurogenesis#GO:0022008;cell projection morphogenesis#GO:0048858;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron projection morphogenesis#GO:0048812;neuron differentiation#GO:0030182;developmental process#GO:0032502;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;axon development#GO:0061564;cell-cell adhesion#GO:0098609;neuron projection development#GO:0031175;cellular process#GO:0009987 cell junction#GO:0030054;cellular anatomical structure#GO:0110165;adherens junction#GO:0005912;anchoring junction#GO:0070161;cell-cell junction#GO:0005911 cadherin#PC00057 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HUMAN|HGNC=10941|UniProtKB=P43003 P43003 SLC1A3 PTHR11958:SF24 SODIUM/DICARBOXYLATE SYMPORTER-RELATED EXCITATORY AMINO ACID TRANSPORTER 1 symporter activity#GO:0015293;sodium:dicarboxylate symporter activity#GO:0017153;monoatomic cation transmembrane transporter activity#GO:0008324;amino acid transmembrane transporter activity#GO:0015171;secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;carboxylic acid transmembrane transporter activity#GO:0046943;solute:sodium symporter activity#GO:0015370;amino acid:sodium symporter activity#GO:0005283;neutral L-amino acid transmembrane transporter activity#GO:0015175;transmembrane transporter activity#GO:0022857;solute:monoatomic cation symporter activity#GO:0015294;dicarboxylic acid transmembrane transporter activity#GO:0005310;L-glutamate transmembrane transporter activity#GO:0005313;acidic amino acid transmembrane transporter activity#GO:0015172;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;L-amino acid transmembrane transporter activity#GO:0015179 carboxylic acid transport#GO:0046942;transport#GO:0006810;organic acid transport#GO:0015849;C4-dicarboxylate transport#GO:0015740;acidic amino acid transport#GO:0015800;amino acid transport#GO:0006865;establishment of localization#GO:0051234;import into cell#GO:0098657;nitrogen compound transport#GO:0071705;aspartate transmembrane transport#GO:0015810;L-amino acid transport#GO:0015807;cellular process#GO:0009987;dicarboxylic acid transport#GO:0006835;L-glutamate transmembrane transport#GO:0015813;L-glutamate import#GO:0051938;amino acid transmembrane transport#GO:0003333;transmembrane transport#GO:0055085;localization#GO:0051179;L-alpha-amino acid transmembrane transport#GO:1902475;import across plasma membrane#GO:0098739;carboxylic acid transmembrane transport#GO:1905039 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 primary active transporter#PC00068 Metabotropic glutamate receptor group III pathway#P00039>EAAT#P01036;Ionotropic glutamate receptor pathway#P00037>EAAT#P01011 HUMAN|HGNC=12759|UniProtKB=Q9P2S5 Q9P2S5 WRAP73 PTHR16220:SF1 WD REPEAT PROTEIN 8-RELATED WD REPEAT-CONTAINING PROTEIN WRAP73 mitotic nuclear division#GO:0140014;cell cycle process#GO:0022402;membraneless organelle assembly#GO:0140694;nuclear chromosome segregation#GO:0098813;cellular component organization#GO:0016043;sister chromatid segregation#GO:0000819;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cell cycle#GO:0007049;mitotic spindle organization#GO:0007052;mitotic cell cycle#GO:0000278;nuclear division#GO:0000280;organelle assembly#GO:0070925;microtubule cytoskeleton organization#GO:0000226;organelle fission#GO:0048285;mitotic spindle assembly#GO:0090307;cellular process#GO:0009987;spindle assembly#GO:0051225;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;mitotic sister chromatid segregation#GO:0000070;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;chromosome segregation#GO:0007059;microtubule-based process#GO:0007017;chromosome organization#GO:0051276;mitotic cell cycle process#GO:1903047;cellular component organization or biogenesis#GO:0071840;spindle organization#GO:0007051 centrosome#GO:0005813;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;microtubule cytoskeleton#GO:0015630;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232 HUMAN|HGNC=14241|UniProtKB=Q9H0K4 Q9H0K4 RSPH6A PTHR13159:SF1 RADIAL SPOKEHEAD-RELATED RADIAL SPOKE HEAD PROTEIN 6 HOMOLOG A microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection assembly#GO:0120031;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;axoneme assembly#GO:0035082;cilium organization#GO:0044782;microtubule cytoskeleton organization#GO:0000226;cilium movement#GO:0003341;microtubule bundle formation#GO:0001578;organelle assembly#GO:0070925;cell projection organization#GO:0030030;microtubule-based movement#GO:0007018;cellular component organization#GO:0016043;cilium assembly#GO:0060271 intracellular organelle#GO:0043229;cilium#GO:0005929;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;axoneme#GO:0005930;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;ciliary plasm#GO:0097014;cellular anatomical structure#GO:0110165;organelle#GO:0043226 microtubule or microtubule-binding cytoskeletal protein#PC00157;cytoskeletal protein#PC00085 HUMAN|HGNC=12663|UniProtKB=P19320 P19320 VCAM1 PTHR13771:SF14 INTERCELLULAR ADHESION MOLECULE VASCULAR CELL ADHESION PROTEIN 1 receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677 cellular process#GO:0009987;cell adhesion mediated by integrin#GO:0033627;leukocyte cell-cell adhesion#GO:0007159;cell adhesion#GO:0007155;cell-cell adhesion#GO:0098609 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;extracellular region#GO:0005576;cell periphery#GO:0071944 cell adhesion molecule#PC00069 HUMAN|HGNC=19607|UniProtKB=Q8NH19 Q8NH19 OR10AG1 PTHR26453:SF159 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 10AG1 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 system process#GO:0003008;nervous system process#GO:0050877;sensory perception#GO:0007600;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;response to stimulus#GO:0050896;response to chemical#GO:0042221;detection of chemical stimulus#GO:0009593;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=25512|UniProtKB=Q5VTL8 Q5VTL8 PRPF38B PTHR23142:SF2 PRE-MRNA-SPLICING FACTOR 38A-RELATED PRE-MRNA-SPLICING FACTOR 38B nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;spliceosomal complex#GO:0005681;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;precatalytic spliceosome#GO:0071011;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229 HUMAN|HGNC=8941|UniProtKB=P01009 P01009 SERPINA1 PTHR11461:SF165 SERINE PROTEASE INHIBITOR, SERPIN ALPHA-1-ANTITRYPSIN peptidase regulator activity#GO:0061134;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414;serine-type endopeptidase inhibitor activity#GO:0004867;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;enzyme inhibitor activity#GO:0004857;molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease inhibitor#PC00191 Blood coagulation#P00011>alpha1-antitrypsin#P00421 HUMAN|HGNC=6340|UniProtKB=Q14943 Q14943 KIR3DS1 PTHR11738:SF166 MHC CLASS I NK CELL RECEPTOR KILLER CELL IMMUNOGLOBULIN-LIKE RECEPTOR 3DL1-RELATED transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;immune receptor activity#GO:0140375;signaling receptor activity#GO:0038023 response to stimulus#GO:0050896;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007;signaling#GO:0023052;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;immune response-regulating signaling pathway#GO:0002764;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;regulation of immune response#GO:0050776;regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=13029|UniProtKB=Q9UJ78 Q9UJ78 ZMYM5 PTHR45736:SF7 ZINC FINGER MYM-TYPE PROTEIN ZINC FINGER MYM-TYPE PROTEIN 5 zinc finger transcription factor#PC00244;DNA-binding transcription factor#PC00218 HUMAN|HGNC=26896|UniProtKB=Q6NW40 Q6NW40 RGMB PTHR31428:SF5 RGM DOMAIN FAMILY MEMBER DRAG-1 REPULSIVE GUIDANCE MOLECULE B coreceptor activity#GO:0015026;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cellular response to growth factor stimulus#GO:0071363;response to endogenous stimulus#GO:0009719;BMP signaling pathway#GO:0030509;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to growth factor#GO:0070848;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;signaling#GO:0023052;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;cell surface receptor signaling pathway#GO:0007166;response to BMP#GO:0071772;cellular response to BMP stimulus#GO:0071773;cellular process#GO:0009987;signal transduction#GO:0007165;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;biological regulation#GO:0065007 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 HUMAN|HGNC=20316|UniProtKB=Q86TN4 Q86TN4 TRPT1 PTHR12684:SF2 PUTATIVE PHOSPHOTRANSFERASE TRNA 2'-PHOSPHOTRANSFERASE 1 transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098;phosphotransferase activity, alcohol group as acceptor#GO:0016773 tRNA splicing, via endonucleolytic cleavage and ligation#GO:0006388;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;gene expression#GO:0010467;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033 transferase#PC00220;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=7688|UniProtKB=Q16718 Q16718 NDUFA5 PTHR12653:SF0 NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-B SUBUNIT NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 5 energy derivation by oxidation of organic compounds#GO:0015980;cellular respiration#GO:0045333;electron transport chain#GO:0022900;metabolic process#GO:0008152;cellular process#GO:0009987;respiratory electron transport chain#GO:0022904;generation of precursor metabolites and energy#GO:0006091 catalytic complex#GO:1902494;respiratory chain complex I#GO:0045271;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;respiratory chain complex#GO:0098803;membrane protein complex#GO:0098796;membrane#GO:0016020;oxidoreductase complex#GO:1990204;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 oxidoreductase#PC00176 HUMAN|HGNC=29188|UniProtKB=Q08AD1 Q08AD1 CAMSAP2 PTHR21595:SF1 PATRONIN CALMODULIN-REGULATED SPECTRIN-ASSOCIATED PROTEIN 2 cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;microtubule binding#GO:0008017;binding#GO:0005488;protein binding#GO:0005515 cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;regulation of microtubule polymerization or depolymerization#GO:0031110;regulation of protein depolymerization#GO:1901879;negative regulation of cellular process#GO:0048523;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;regulation of microtubule cytoskeleton organization#GO:0070507;negative regulation of protein depolymerization#GO:1901880;regulation of protein-containing complex disassembly#GO:0043244;organelle organization#GO:0006996;cellular process#GO:0009987;negative regulation of cytoskeleton organization#GO:0051494;microtubule cytoskeleton organization#GO:0000226;negative regulation of protein-containing complex disassembly#GO:0043242;supramolecular fiber organization#GO:0097435;regulation of microtubule-based process#GO:0032886;regulation of cytoskeleton organization#GO:0051493;negative regulation of supramolecular fiber organization#GO:1902904;regulation of cellular component organization#GO:0051128;cytoplasmic microtubule organization#GO:0031122;regulation of cellular process#GO:0050794;negative regulation of biological process#GO:0048519;negative regulation of cellular component organization#GO:0051129;negative regulation of organelle organization#GO:0010639;cellular component organization#GO:0016043;regulation of supramolecular fiber organization#GO:1902903;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;microtubule#GO:0005874;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule cytoskeleton#GO:0015630;microtubule end#GO:1990752;organelle#GO:0043226;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232 HUMAN|HGNC=25708|UniProtKB=Q96JM4 Q96JM4 LRRIQ1 PTHR46652:SF11 LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED LEUCINE-RICH REPEAT- AND IQ DOMAIN-CONTAINING PROTEIN 1 HUMAN|HGNC=1805|UniProtKB=P47902 P47902 CDX1 PTHR24332:SF16 HOMEOBOX PROTEIN CDX HOMEOBOX PROTEIN CDX-1 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;animal gross anatomical part developmental process#GO:0160108;pattern specification process#GO:0007389;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;embryonic pattern specification#GO:0009880;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;multicellular organismal process#GO:0032501;regionalization#GO:0003002;regulation of nucleobase-containing compound metabolic process#GO:0019219;embryo development#GO:0009790;tube development#GO:0035295;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;anterior/posterior pattern specification#GO:0009952;developmental process#GO:0032502;cellular developmental process#GO:0048869;anterior/posterior axis specification#GO:0009948;regulation of biosynthetic process#GO:0009889;multicellular organism development#GO:0007275;regulation of gene expression#GO:0010468 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=15487|UniProtKB=Q9H3N1 Q9H3N1 TMX1 PTHR46107:SF2 DUMPY: SHORTER THAN WILD-TYPE THIOREDOXIN-RELATED TRANSMEMBRANE PROTEIN 1 oxidoreductase activity#GO:0016491;disulfide oxidoreductase activity#GO:0015036;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;catalytic activity#GO:0003824 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 HUMAN|HGNC=404|UniProtKB=P05091 P05091 ALDH2 PTHR11699:SF233 ALDEHYDE DEHYDROGENASE-RELATED ALDEHYDE DEHYDROGENASE, MITOCHONDRIAL oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the aldehyde or oxo group of donors#GO:0016903;oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor#GO:0016620;aldehyde dehydrogenase (NAD+) activity#GO:0004029 response to toxic substance#GO:0009636;catabolic process#GO:0009056;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular detoxification of aldehyde#GO:0110095;cellular detoxification#GO:1990748;response to oxygen-containing compound#GO:1901700;cellular response to chemical stimulus#GO:0070887;aldehyde catabolic process#GO:0046185;cellular response to toxic substance#GO:0097237;detoxification#GO:0098754;response to chemical#GO:0042221;aldehyde metabolic process#GO:0006081;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;metabolic process#GO:0008152 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 metabolite interconversion enzyme#PC00262;dehydrogenase#PC00092 5-Hydroxytryptamine degredation#P04372>Aldehyde Dehydrogenase#P04402 HUMAN|HGNC=10449|UniProtKB=Q92766 Q92766 RREB1 PTHR46451:SF1 RAS-RESPONSIVE ELEMENT-BINDING PROTEIN 1 RAS-RESPONSIVE ELEMENT-BINDING PROTEIN 1 sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;DNA-binding transcription activator activity#GO:0001216;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=10966|UniProtKB=O15244 O15244 SLC22A2 PTHR24064:SF432 SOLUTE CARRIER FAMILY 22 MEMBER SOLUTE CARRIER FAMILY 22 MEMBER 2 quaternary ammonium group transmembrane transporter activity#GO:0015651;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoamine transmembrane transporter activity#GO:0008504;active transmembrane transporter activity#GO:0022804 cellular process#GO:0009987;nitrogen compound transport#GO:0071705;quaternary ammonium group transport#GO:0015697;organic hydroxy compound transport#GO:0015850;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 secondary carrier transporter#PC00258 HUMAN|HGNC=4274|UniProtKB=P17302 P17302 GJA1 PTHR11984:SF33 CONNEXIN GAP JUNCTION ALPHA-1 PROTEIN channel activity#GO:0015267;wide pore channel activity#GO:0022829;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803 cellular process#GO:0009987;regulation of biological process#GO:0050789;multicellular organismal process#GO:0032501;circulatory system development#GO:0072359;heart development#GO:0007507;biological regulation#GO:0065007;signaling#GO:0023052;cell-cell signaling#GO:0007267;animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502;anatomical structure development#GO:0048856;animal organ development#GO:0048513;multicellular organism development#GO:0007275;cell communication#GO:0007154;system development#GO:0048731 anchoring junction#GO:0070161;cell junction#GO:0030054;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane protein complex#GO:0098796;membrane#GO:0016020;cell-cell junction#GO:0005911;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 gap junction#PC00105;cell junction protein#PC00070 HUMAN|HGNC=12736|UniProtKB=O43516 O43516 WIPF1 PTHR48226:SF1 OS06G0326200 PROTEIN WAS_WASL-INTERACTING PROTEIN FAMILY MEMBER 1 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;cytoskeletal adaptor activity#GO:0008093 actin filament-based process#GO:0030029;cellular process#GO:0009987;actin filament-based movement#GO:0030048 actin filament#GO:0005884;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;actin cytoskeleton#GO:0015629;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;supramolecular complex#GO:0099080;organelle#GO:0043226 HUMAN|HGNC=15204|UniProtKB=Q8NGJ8 Q8NGJ8 OR51S1 PTHR26450:SF73 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 51S1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=10600|UniProtKB=P51168 P51168 SCNN1B PTHR11690:SF18 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED EPITHELIAL SODIUM CHANNEL SUBUNIT BETA channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;gated channel activity#GO:0022836;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation channel activity#GO:0005261;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;ligand-gated monoatomic cation channel activity#GO:0099094;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;sodium channel activity#GO:0005272 sodium ion transmembrane transport#GO:0035725;sodium ion transport#GO:0006814;cellular process#GO:0009987;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;establishment of localization#GO:0051234;transmembrane transport#GO:0055085 cation channel complex#GO:0034703;sodium channel complex#GO:0034706;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cell periphery#GO:0071944;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991 ion channel#PC00133;transporter#PC00227 HUMAN|HGNC=5348|UniProtKB=Q9UMF0 Q9UMF0 ICAM5 PTHR13771:SF19 INTERCELLULAR ADHESION MOLECULE INTERCELLULAR ADHESION MOLECULE 5 signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018 cell adhesion mediated by integrin#GO:0033627;cell adhesion#GO:0007155;leukocyte cell-cell adhesion#GO:0007159;cellular process#GO:0009987;cell-cell adhesion#GO:0098609 membrane#GO:0016020;extracellular region#GO:0005576;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cell adhesion molecule#PC00069 HUMAN|HGNC=6694|UniProtKB=P98164 P98164 LRP2 PTHR22722:SF11 LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2 hormone binding#GO:0042562;binding#GO:0005488 localization#GO:0051179;establishment of localization#GO:0051234;import into cell#GO:0098657;receptor-mediated endocytosis#GO:0006898;transport#GO:0006810;endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;apical plasma membrane#GO:0016324;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane region#GO:0098590;signaling receptor complex#GO:0043235;apical part of cell#GO:0045177 Alzheimer disease-presenilin pathway#P00004>LRP transmembrane fragment#P00152;Alzheimer disease-presenilin pathway#P00004>LRP#P00150;Alzheimer disease-presenilin pathway#P00004>LRP N-terminal fragment#P00169;Alzheimer disease-presenilin pathway#P00004>LRP C-terminal fragment#P00112;Alzheimer disease-presenilin pathway#P00004>LRP intracellular fragment#P00173 HUMAN|HGNC=20441|UniProtKB=Q96FQ6 Q96FQ6 S100A16 PTHR11639:SF76 S100 CALCIUM-BINDING PROTEIN PROTEIN S100-A16 calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;cation binding#GO:0043169;protein binding#GO:0005515;metal ion binding#GO:0046872 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;perinuclear region of cytoplasm#GO:0048471;cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 calmodulin-related#PC00061;calcium-binding protein#PC00060 HUMAN|HGNC=12920|UniProtKB=P52737 P52737 ZNF136 PTHR24377:SF984 IP01015P-RELATED ZINC FINGER PROTEIN 136 RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=1659|UniProtKB=P20138 P20138 CD33 PTHR12035:SF132 SIALIC ACID BINDING IMMUNOGLOBULIN-LIKE LECTIN MYELOID CELL SURFACE ANTIGEN CD33 organic acid binding#GO:0043177;anion binding#GO:0043168;binding#GO:0005488;carboxylic acid binding#GO:0031406;small molecule binding#GO:0036094;ion binding#GO:0043167;carbohydrate derivative binding#GO:0097367 cellular process#GO:0009987;cell adhesion#GO:0007155 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;immunoglobulin superfamily cell adhesion molecule#PC00125 HUMAN|HGNC=24665|UniProtKB=Q6Q8B3 Q6Q8B3 CD200R1L PTHR21462:SF6 CELL SURFACE GLYCOPROTEIN OX2 RECEPTOR PRECURSOR CELL SURFACE GLYCOPROTEIN CD200 RECEPTOR 2 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 regulation of response to stress#GO:0080134;regulation of defense response#GO:0031347;regulation of inflammatory response#GO:0050727;regulation of response to stimulus#GO:0048583;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of response to stimulus#GO:0048585;negative regulation of defense response#GO:0031348;regulation of immune system process#GO:0002682;regulation of response to external stimulus#GO:0032101;negative regulation of inflammatory response#GO:0050728;negative regulation of response to external stimulus#GO:0032102;biological regulation#GO:0065007 external side of plasma membrane#GO:0009897;signaling receptor complex#GO:0043235;side of membrane#GO:0098552;membrane#GO:0016020;cell periphery#GO:0071944;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=11569|UniProtKB=Q15633 Q15633 TARBP2 PTHR46205:SF1 LOQUACIOUS, ISOFORM B RISC-LOADING COMPLEX SUBUNIT TARBP2 binding#GO:0005488;nucleic acid binding#GO:0003676;double-stranded RNA binding#GO:0003725;RNA binding#GO:0003723 nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;negative regulation of macromolecule metabolic process#GO:0010605;macromolecule biosynthetic process#GO:0009059;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;regulatory ncRNA processing#GO:0070918;regulation of biosynthetic process#GO:0009889;regulatory ncRNA-mediated gene silencing#GO:0031047;negative regulation of cellular process#GO:0048523;RNA biosynthetic process#GO:0032774;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;negative regulation of metabolic process#GO:0009892;regulation of gene silencing by regulatory ncRNA#GO:0060966;regulation of biological process#GO:0050789;siRNA processing#GO:0030422;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ribonucleoprotein complex#GO:1990904;endoribonuclease complex#GO:1902555;endonuclease complex#GO:1905348;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 HUMAN|HGNC=26851|UniProtKB=Q8NDH2 Q8NDH2 LRTM3 PTHR35542:SF2 COILED-COIL DOMAIN-CONTAINING PROTEIN 168 LEUCINE-RICH REPEAT TRANSMEMBRANE PROTEIN 3 HUMAN|HGNC=25889|UniProtKB=Q17RM4 Q17RM4 CCDC142 PTHR21436:SF2 COILED-COIL DOMAIN-CONTAINING PROTEIN 142 COILED-COIL DOMAIN-CONTAINING PROTEIN 142 HUMAN|HGNC=2845|UniProtKB=P98153 P98153 DGCR2 PTHR15256:SF6 INTEGRAL MEMBRANE PROTEIN DGCR2/IDD INTEGRAL MEMBRANE PROTEIN DGCR2_IDD cellular anatomical structure#GO:0110165;membrane#GO:0016020 HUMAN|HGNC=30922|UniProtKB=Q8NG48 Q8NG48 LINS1 PTHR16057:SF1 WINS1, 2 PROTEIN PROTEIN LINES HOMOLOG 1 HUMAN|HGNC=12192|UniProtKB=A0A087X0K7 A0A087X0K7 TRBV17 PTHR23268:SF93 T-CELL RECEPTOR BETA CHAIN NON-FUNCTIONAL T CELL RECEPTOR BETA VARIABLE 17-RELATED cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=13447|UniProtKB=Q9H2H9 Q9H2H9 SLC38A1 PTHR22950:SF184 AMINO ACID TRANSPORTER SODIUM-COUPLED NEUTRAL AMINO ACID SYMPORTER 1 L-amino acid transmembrane transporter activity#GO:0015179;neutral L-amino acid transmembrane transporter activity#GO:0015175;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;amino acid transmembrane transporter activity#GO:0015171 amino acid transmembrane transport#GO:0003333;establishment of localization#GO:0051234;neutral amino acid transport#GO:0015804;transmembrane transport#GO:0055085;localization#GO:0051179;organic acid transport#GO:0015849;transport#GO:0006810;carboxylic acid transport#GO:0046942;amino acid transport#GO:0006865;cellular process#GO:0009987;nitrogen compound transport#GO:0071705;L-amino acid transport#GO:0015807 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 amino acid transporter#PC00046;secondary carrier transporter#PC00258 HUMAN|HGNC=30729|UniProtKB=Q8WYN3 Q8WYN3 CSRNP3 PTHR13580:SF13 TGF-BETA INDUCED APOPTOSIS PROTEIN CYSTEINE_SERINE-RICH NUCLEAR PROTEIN 3 nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=8584|UniProtKB=P05120 P05120 SERPINB2 PTHR11461:SF61 SERINE PROTEASE INHIBITOR, SERPIN PLASMINOGEN ACTIVATOR INHIBITOR 2 endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772;enzyme inhibitor activity#GO:0004857;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;serine-type endopeptidase inhibitor activity#GO:0004867;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;peptidase regulator activity#GO:0061134 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 Plasminogen activating cascade#P00050>PAI-2#P01244;CCKR signaling map#P06959>PAI2#G06977;CCKR signaling map#P06959>PAI2#G07270;Blood coagulation#P00011>PAI-2#P00409 HUMAN|HGNC=1079|UniProtKB=P51813 P51813 BMX PTHR24418:SF91 TYROSINE-PROTEIN KINASE CYTOPLASMIC TYROSINE-PROTEIN KINASE BMX non-membrane spanning protein tyrosine kinase activity#GO:0004715;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein tyrosine kinase activity#GO:0004713;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 non-receptor tyrosine protein kinase#PC00168 HUMAN|HGNC=1435|UniProtKB=P22676 P22676 CALB2 PTHR19972:SF4 CALBINDIN CALRETININ metal ion binding#GO:0046872;cation binding#GO:0043169;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;calcium ion binding#GO:0005509 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;dendrite#GO:0030425;intracellular organelle#GO:0043229;axon#GO:0030424;dendritic tree#GO:0097447;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;neuron projection terminus#GO:0044306;cell projection#GO:0042995;terminal bouton#GO:0043195;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;distal axon#GO:0150034;cell junction#GO:0030054;axon terminus#GO:0043679;somatodendritic compartment#GO:0036477;cytoplasm#GO:0005737;cytosol#GO:0005829;presynapse#GO:0098793;neuron projection#GO:0043005;nucleus#GO:0005634 calmodulin-related#PC00061 HUMAN|HGNC=9582|UniProtKB=P25105 P25105 PTAFR PTHR24233:SF6 P2Y PURINOCEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR PLATELET-ACTIVATING FACTOR RECEPTOR signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CHKR#P00854 HUMAN|HGNC=30855|UniProtKB=O15042 O15042 U2SURP PTHR23140:SF0 RNA PROCESSING PROTEIN LD23810P U2 SNRNP-ASSOCIATED SURP MOTIF-CONTAINING PROTEIN binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 RNA processing factor#PC00147 HUMAN|HGNC=12931|UniProtKB=Q15072 Q15072 ZNF146 PTHR24377:SF1014 IP01015P-RELATED ZINC FINGER PROTEIN OZF RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=33777|UniProtKB=Q6UWW0 Q6UWW0 LCN15 PTHR11430:SF64 LIPOCALIN LIPOCALIN-15 transfer/carrier protein#PC00219 HUMAN|HGNC=3821|UniProtKB=O43524 O43524 FOXO3 PTHR45767:SF4 FORKHEAD BOX PROTEIN O FORKHEAD BOX PROTEIN O3-RELATED transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;response to starvation#GO:0042594;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;response to stress#GO:0006950;response to nutrient levels#GO:0031667;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;mitochondrion#GO:0005739;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 winged helix/forkhead transcription factor#PC00246 Insulin/IGF pathway-protein kinase B signaling cascade#P00033>FKHR#P00898;Interleukin signaling pathway#P00036>FKHRL1#P00994;PI3 kinase pathway#P00048>FOXO#P01198;CCKR signaling map#P06959>FOXO3#P07073 HUMAN|HGNC=18261|UniProtKB=Q8TAT6 Q8TAT6 NPLOC4 PTHR12710:SF0 NUCLEAR PROTEIN LOCALIZATION 4 NUCLEAR PROTEIN LOCALIZATION PROTEIN 4 HOMOLOG proteasomal protein catabolic process#GO:0010498;response to chemical#GO:0042221;cellular process#GO:0009987;response to stress#GO:0006950;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;catabolic process#GO:0009056;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;ERAD pathway#GO:0036503;protein metabolic process#GO:0019538;modification-dependent macromolecule catabolic process#GO:0043632;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;response to endoplasmic reticulum stress#GO:0034976 endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;endoplasmic reticulum protein-containing complex#GO:0140534;membrane#GO:0016020;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226 HUMAN|HGNC=2091|UniProtKB=P09497 P09497 CLTB PTHR10639:SF28 CLATHRIN LIGHT CHAIN CLATHRIN LIGHT CHAIN B clathrin binding#GO:0030276;binding#GO:0005488;protein binding#GO:0005515 transport#GO:0006810;receptor-mediated endocytosis#GO:0006898;establishment of localization#GO:0051234;import into cell#GO:0098657;localization#GO:0051179;clathrin-dependent endocytosis#GO:0072583;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;endocytosis#GO:0006897 intracellular membrane-bounded organelle#GO:0043231;synaptic vesicle membrane#GO:0030672;vesicle#GO:0031982;synaptic vesicle#GO:0008021;membrane protein complex#GO:0098796;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane coat#GO:0030117;plasma membrane#GO:0005886;transport vesicle#GO:0030133;endomembrane system#GO:0012505;transport vesicle membrane#GO:0030658;cell periphery#GO:0071944;vesicle membrane#GO:0012506;membrane#GO:0016020;organelle membrane#GO:0031090;clathrin-coated vesicle#GO:0030136;coated vesicle membrane#GO:0030662;organelle#GO:0043226;clathrin coat#GO:0030118;synapse#GO:0045202;cellular anatomical structure#GO:0110165;intracellular vesicle#GO:0097708;coated vesicle#GO:0030135;coated membrane#GO:0048475;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;vesicle coat#GO:0030120;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;presynapse#GO:0098793;secretory vesicle#GO:0099503;bounding membrane of organelle#GO:0098588;cell junction#GO:0030054;clathrin-coated vesicle membrane#GO:0030665;clathrin vesicle coat#GO:0030125 membrane traffic protein#PC00150;vesicle coat protein#PC00235 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Clathrin#P00738;Huntington disease#P00029>Clathrin#P00798;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Clathrin#P00722 HUMAN|HGNC=7759|UniProtKB=Q9Y3R4 Q9Y3R4 NEU2 PTHR10628:SF6 SIALIDASE SIALIDASE-2 catalytic activity#GO:0003824;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787 primary metabolic process#GO:0044238;sphingolipid catabolic process#GO:0030149;carbohydrate metabolic process#GO:0005975;carbohydrate derivative catabolic process#GO:1901136;oligosaccharide catabolic process#GO:0009313;catabolic process#GO:0009056;liposaccharide metabolic process#GO:1903509;glycolipid metabolic process#GO:0006664;carbohydrate catabolic process#GO:0016052;ceramide metabolic process#GO:0006672;lipid catabolic process#GO:0016042;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;lipid metabolic process#GO:0006629;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;oligosaccharide metabolic process#GO:0009311 membrane#GO:0016020;lysosome#GO:0005764;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;vacuole#GO:0005773;intracellular organelle#GO:0043229;lytic vacuole#GO:0000323;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 hydrolase#PC00121 HUMAN|HGNC=10669|UniProtKB=Q6ZSZ6 Q6ZSZ6 TSHZ1 PTHR12487:SF6 TEASHIRT-RELATED TEASHIRT HOMOLOG 1 DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=23529|UniProtKB=Q8TEA1 Q8TEA1 NSUN6 PTHR22807:SF34 NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING TRNA (CYTOSINE(72)-C(5))-METHYLTRANSFERASE NSUN6 tRNA methyltransferase activity#GO:0008175;catalytic activity, acting on RNA#GO:0140098;RNA methyltransferase activity#GO:0008173;rRNA methyltransferase activity#GO:0008649;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on a rRNA#GO:0140102;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168 cellular component biogenesis#GO:0044085;cellular process#GO:0009987;rRNA base methylation#GO:0070475;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;rRNA methylation#GO:0031167;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;rRNA modification#GO:0000154;ribonucleoprotein complex biogenesis#GO:0022613;tRNA modification#GO:0006400;RNA biosynthetic process#GO:0032774;ribosome biogenesis#GO:0042254;RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187;macromolecule methylation#GO:0043414;RNA methylation#GO:0001510;methylation#GO:0032259;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;rRNA processing#GO:0006364 RNA methyltransferase#PC00033;RNA metabolism protein#PC00031 HUMAN|HGNC=26434|UniProtKB=Q6P1S2 Q6P1S2 MISO1 PTHR28434:SF1 PROTEIN C3ORF33 MITOCHONDRIAL INNER MEMBRANE SUBDOMAIN ORGANIZER 1 HUMAN|HGNC=29593|UniProtKB=Q7Z713 Q7Z713 ANKRD37 PTHR24201:SF0 ANK_REP_REGION DOMAIN-CONTAINING PROTEIN ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 37 molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;enzyme inhibitor activity#GO:0004857;cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538;cyclin-dependent protein serine/threonine kinase inhibitor activity#GO:0004861;kinase regulator activity#GO:0019207;protein kinase inhibitor activity#GO:0004860;molecular function regulator activity#GO:0098772;protein kinase regulator activity#GO:0019887;cyclin-dependent protein kinase regulator activity#GO:0019914;kinase inhibitor activity#GO:0019210 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 kinase inhibitor#PC00139;protein-binding activity modulator#PC00095 HUMAN|HGNC=15489|UniProtKB=Q9NQX6 Q9NQX6 ZNF331 PTHR24384:SF233 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED ZINC FINGER PROTEIN 331 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218 HUMAN|HGNC=32954|UniProtKB=Q5I0X7 Q5I0X7 TTC32 PTHR47059:SF1 TETRATRICOPEPTIDE REPEAT PROTEIN 32 TETRATRICOPEPTIDE REPEAT PROTEIN 32 HUMAN|HGNC=28856|UniProtKB=Q96A37 Q96A37 RNF166 PTHR46016:SF4 ZINC FINGER, RING/FYVE/PHD-TYPE E3 UBIQUITIN-PROTEIN LIGASE RNF166 ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein modification by small protein conjugation or removal#GO:0070647;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;protein modification process#GO:0036211;catabolic process#GO:0009056;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567 HUMAN|HGNC=14338|UniProtKB=Q9HB20 Q9HB20 PLEKHA3 PTHR22902:SF60 SESQUIPEDALIAN PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 3 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 membrane traffic protein#PC00150 HUMAN|HGNC=9567|UniProtKB=O00233 O00233 PSMD9 PTHR12651:SF1 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9 protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043 catalytic complex#GO:1902494;intracellular organelle#GO:0043229;endopeptidase complex#GO:1905369;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;proteasome complex#GO:0000502;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;peptidase complex#GO:1905368;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226 protease#PC00190;protein modifying enzyme#PC00260 Ubiquitin proteasome pathway#P00060>26S proteasome#P01489 HUMAN|HGNC=16859|UniProtKB=O75052 O75052 NOS1AP PTHR11232:SF76 PHOSPHOTYROSINE INTERACTION DOMAIN-CONTAINING FAMILY MEMBER CARBOXYL-TERMINAL PDZ LIGAND OF NEURONAL NITRIC OXIDE SYNTHASE PROTEIN molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;signaling adaptor activity#GO:0035591 cellular anatomical structure#GO:0110165;synapse#GO:0045202;glutamatergic synapse#GO:0098978;cell junction#GO:0030054 scaffold/adaptor protein#PC00226 HUMAN|HGNC=28423|UniProtKB=Q96MF2 Q96MF2 STAC3 PTHR15135:SF2 STAC SH3 AND CYSTEINE-RICH DOMAIN-CONTAINING PROTEIN 3 channel regulator activity#GO:0016247;molecular function regulator activity#GO:0098772;ion channel regulator activity#GO:0099106;calcium channel regulator activity#GO:0005246;transporter regulator activity#GO:0141108 system process#GO:0003008;regulation of localization#GO:0032879;muscle contraction#GO:0006936;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;positive regulation of cellular process#GO:0048522;regulation of protein localization to membrane#GO:1905475;positive regulation of biological process#GO:0048518;regulation of protein localization#GO:0032880;neuromuscular process#GO:0050905;nervous system process#GO:0050877;skeletal muscle contraction#GO:0003009;striated muscle contraction#GO:0006941;regulation of cellular process#GO:0050794;muscle system process#GO:0003012;regulation of biological process#GO:0050789 cell periphery#GO:0071944;cytoplasmic side of membrane#GO:0098562;cytoplasmic side of plasma membrane#GO:0009898;membrane#GO:0016020;plasma membrane#GO:0005886;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165 HUMAN|HGNC=31860|UniProtKB=Q6NSI3 Q6NSI3 FAM53A PTHR28567:SF2 PROTEIN FAM53A-LIKE ISOFORM X1 PROTEIN FAM53A localization#GO:0051179;cellular localization#GO:0051641;nuclear transport#GO:0051169;protein import into nucleus#GO:0006606;protein transport#GO:0015031;nucleocytoplasmic transport#GO:0006913;protein localization to organelle#GO:0033365;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;transport#GO:0006810;intracellular protein transport#GO:0006886;macromolecule localization#GO:0033036;import into nucleus#GO:0051170;protein localization to nucleus#GO:0034504;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=11049|UniProtKB=Q01959 Q01959 SLC6A3 PTHR11616:SF38 SODIUM/CHLORIDE DEPENDENT TRANSPORTER SODIUM-DEPENDENT DOPAMINE TRANSPORTER monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;transport#GO:0006810;amino acid transport#GO:0006865;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;monoatomic ion transmembrane transport#GO:0034220;sodium ion transmembrane transport#GO:0035725;sodium ion transport#GO:0006814;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 primary active transporter#PC00068 Adrenaline and noradrenaline biosynthesis#P00001>DAT#P00065;Parkinson disease#P00049>DAT#P01228;Dopamine receptor mediated signaling pathway#P05912>DAT#P05962;Parkinson disease#P00049>DAT#G01547 HUMAN|HGNC=11849|UniProtKB=O15455 O15455 TLR3 PTHR24373:SF293 SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN TOLL-LIKE RECEPTOR 3 signaling receptor activity#GO:0038023;RNA binding#GO:0003723;molecular transducer activity#GO:0060089;double-stranded RNA binding#GO:0003725;nucleic acid binding#GO:0003676;binding#GO:0005488 response to nitrogen compound#GO:1901698;response to chemical#GO:0042221;response to stimulus#GO:0050896 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 Toll receptor signaling pathway#P00054>TLR#P01346;Toll receptor signaling pathway#P00054>TLR3#P01340 HUMAN|HGNC=14545|UniProtKB=Q8IV61 Q8IV61 RASGRP3 PTHR23113:SF178 GUANINE NUCLEOTIDE EXCHANGE FACTOR RAS GUANYL-RELEASING PROTEIN 3 molecular function regulator activity#GO:0098772;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;guanyl-nucleotide exchange factor activity#GO:0005085 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;small GTPase-mediated signal transduction#GO:0007264;signaling#GO:0023052;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;Ras protein signal transduction#GO:0007265 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 guanyl-nucleotide exchange factor#PC00113 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>CalDAG-GEF#P00736 HUMAN|HGNC=7532|UniProtKB=P20591 P20591 MX1 PTHR11566:SF217 DYNAMIN INTERFERON-INDUCED GTP-BINDING PROTEIN MX1 ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;tubulin binding#GO:0015631;hydrolase activity, acting on acid anhydrides#GO:0016817;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;GTPase activity#GO:0003924;microtubule binding#GO:0008017 cellular localization#GO:0051641;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;establishment of organelle localization#GO:0051656;endocytosis#GO:0006897;defense response to virus#GO:0051607;cellular component organization#GO:0016043;vesicle organization#GO:0016050;cellular component organization or biogenesis#GO:0071840;vesicle-mediated transport in synapse#GO:0099003;import into cell#GO:0098657;establishment of vesicle localization#GO:0051650;vesicle-mediated transport#GO:0016192;synaptic vesicle localization#GO:0097479;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;response to biotic stimulus#GO:0009607;organelle organization#GO:0006996;synaptic vesicle transport#GO:0048489;response to stress#GO:0006950;localization#GO:0051179;response to virus#GO:0009615;organelle localization#GO:0051640;response to external biotic stimulus#GO:0043207;synaptic vesicle endocytosis#GO:0048488;response to external stimulus#GO:0009605;defense response#GO:0006952;vesicle budding from membrane#GO:0006900;establishment of localization#GO:0051234;transport#GO:0006810;synaptic vesicle cycle#GO:0099504;membrane organization#GO:0061024;response to other organism#GO:0051707;synaptic vesicle recycling#GO:0036465;vesicle localization#GO:0051648 microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cell junction#GO:0030054;cytoskeleton#GO:0005856;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;membrane#GO:0016020;microtubule cytoskeleton#GO:0015630;nucleus#GO:0005634 membrane traffic protein#PC00150 HUMAN|HGNC=22978|UniProtKB=O75164 O75164 KDM4A PTHR10694:SF119 LYSINE-SPECIFIC DEMETHYLASE LYSINE-SPECIFIC DEMETHYLASE 4A histone modifying activity#GO:0140993;dioxygenase activity#GO:0051213;histone demethylase activity#GO:0032452;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824;protein demethylase activity#GO:0140457;demethylase activity#GO:0032451;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;oxidoreductase activity#GO:0016491;catalytic activity, acting on a protein#GO:0140096 regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;chromatin remodeling#GO:0006338;chromatin organization#GO:0006325;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;cellular component organization#GO:0016043;cellular process#GO:0009987;regulation of biological process#GO:0050789 chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228 histone modifying enzyme#PC00261 HUMAN|HGNC=27056|UniProtKB=Q6KB66 Q6KB66 KRT80 PTHR45616:SF1 GATA-TYPE DOMAIN-CONTAINING PROTEIN KERATIN, TYPE II CYTOSKELETAL 80 structural molecule activity#GO:0005198 anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;intermediate filament-based process#GO:0045103;keratinocyte differentiation#GO:0030216;animal gross anatomical part developmental process#GO:0160108;intermediate filament organization#GO:0045109;cell differentiation#GO:0030154;intermediate filament cytoskeleton organization#GO:0045104;cellular component organization#GO:0016043;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;animal organ development#GO:0048513;epidermis development#GO:0008544;developmental process#GO:0032502;epithelium development#GO:0060429;epidermal cell differentiation#GO:0009913;tissue development#GO:0009888;epithelial cell differentiation#GO:0030855;multicellular organismal process#GO:0032501;cytoskeleton organization#GO:0007010;skin development#GO:0043588;organelle organization#GO:0006996;cellular process#GO:0009987 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;intermediate filament#GO:0005882;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;organelle#GO:0043226;supramolecular complex#GO:0099080 HUMAN|HGNC=19366|UniProtKB=Q9NVE7 Q9NVE7 PANK4 PTHR12280:SF42 PANTOTHENATE KINASE 4'-PHOSPHOPANTETHEINE PHOSPHATASE hydrolase activity#GO:0016787;phosphotransferase activity, alcohol group as acceptor#GO:0016773;phosphoric ester hydrolase activity#GO:0042578;transferase activity#GO:0016740;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;sulfur compound metabolic process#GO:0006790;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleobase-containing small molecule metabolic process#GO:0055086;nucleoside phosphate biosynthetic process#GO:1901293;purine-containing compound metabolic process#GO:0072521;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;purine-containing compound biosynthetic process#GO:0072522;organophosphate biosynthetic process#GO:0090407 cytosol#GO:0005829;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;kinase#PC00137 Coenzyme A biosynthesis#P02736>Pantothenate kinase#P02885 HUMAN|HGNC=5211|UniProtKB=P37059 P37059 HSD17B2 PTHR43313:SF3 SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C 17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491 biological regulation#GO:0065007;hormone biosynthetic process#GO:0042446;biosynthetic process#GO:0009058;steroid metabolic process#GO:0008202;lipid biosynthetic process#GO:0008610;hormone metabolic process#GO:0042445;cellular process#GO:0009987;regulation of hormone levels#GO:0010817;primary metabolic process#GO:0044238;regulation of biological quality#GO:0065008;steroid biosynthetic process#GO:0006694;lipid metabolic process#GO:0006629;metabolic process#GO:0008152 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;membrane#GO:0016020;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 Androgen/estrogene/progesterone biosynthesis#P02727>Estradiol 17beta-dehydrogenase#P02826 HUMAN|HGNC=9950|UniProtKB=O94762 O94762 RECQL5 PTHR13710:SF152 DNA HELICASE RECQ FAMILY MEMBER ATP-DEPENDENT DNA HELICASE Q5 ATP-dependent activity, acting on DNA#GO:0008094;ATP-dependent activity#GO:0140657;catalytic activity, acting on DNA#GO:0140097;helicase activity#GO:0004386;3'-5' DNA helicase activity#GO:0043138;isomerase activity#GO:0016853;DNA helicase activity#GO:0003678;catalytic activity#GO:0003824;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;macromolecular conformation isomerase activity#GO:0120543 DNA damage response#GO:0006974;DNA recombination#GO:0006310;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;response to stress#GO:0006950;nucleobase-containing compound metabolic process#GO:0006139;cellular response to stress#GO:0033554;recombinational repair#GO:0000725;double-strand break repair via homologous recombination#GO:0000724;cellular response to stimulus#GO:0051716;DNA replication#GO:0006260;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;response to stimulus#GO:0050896 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;chromosome#GO:0005694;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229 DNA metabolism protein#PC00009;DNA helicase#PC00011 HUMAN|HGNC=27606|UniProtKB=Q86XF7 Q86XF7 ZNF575 PTHR23226:SF206 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER PROTEIN 575 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=26062|UniProtKB=Q96HA4 Q96HA4 C1orf159 PTHR16247:SF0 RIKEN CDNA 9430015G10 GENE RIKEN CDNA 9430015G10 GENE HUMAN|HGNC=3435|UniProtKB=P19447 P19447 ERCC3 PTHR11274:SF18 RAD25/XP-B DNA REPAIR HELICASE GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE_TRANSLOCASE SUBUNIT XPB ATP-dependent activity, acting on DNA#GO:0008094;ATP-dependent activity#GO:0140657;helicase activity#GO:0004386;catalytic activity, acting on DNA#GO:0140097;DNA helicase activity#GO:0003678;isomerase activity#GO:0016853;3'-5' DNA helicase activity#GO:0043138;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543 epidermis development#GO:0008544;transcription by RNA polymerase II#GO:0006366;developmental process#GO:0032502;cellular developmental process#GO:0048869;macromolecule metabolic process#GO:0043170;neurogenesis#GO:0022008;macromolecule biosynthetic process#GO:0009059;epidermal cell differentiation#GO:0009913;multicellular organismal process#GO:0032501;epithelial cell differentiation#GO:0030855;tissue development#GO:0009888;epithelium development#GO:0060429;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;anatomical structure development#GO:0048856;system development#GO:0048731;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;neuron differentiation#GO:0030182;multicellular organism development#GO:0007275;hair cell differentiation#GO:0035315;transcription initiation at RNA polymerase II promoter#GO:0006367;cellular process#GO:0009987;gene expression#GO:0010467;nervous system development#GO:0007399;animal gross anatomical part developmental process#GO:0160108;nucleic acid biosynthetic process#GO:0141187;generation of neurons#GO:0048699;RNA metabolic process#GO:0016070;DNA-templated transcription initiation#GO:0006352;cell differentiation#GO:0030154 membrane-enclosed lumen#GO:0031974;RNA polymerase II transcription regulator complex#GO:0090575;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;protein-containing complex#GO:0032991;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;transferase complex#GO:1990234;nucleotide-excision repair complex#GO:0000109;nuclear protein-containing complex#GO:0140513;transcription regulator complex#GO:0005667;intracellular protein-containing complex#GO:0140535;protein kinase complex#GO:1902911;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle#GO:0043226;nucleoplasm#GO:0005654;protein-DNA complex#GO:0032993;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;transcription factor TFIIH holo complex#GO:0005675;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;RNA polymerase II, holoenzyme#GO:0016591;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622 DNA helicase#PC00011;DNA metabolism protein#PC00009 HUMAN|HGNC=51250|UniProtKB=Q0VF49 Q0VF49 KIAA2012 PTHR21937:SF5 CCDC66 DOMAIN-CONTAINING PROTEIN GENE 973-RELATED HUMAN|HGNC=28997|UniProtKB=Q93073 Q93073 SECISBP2L PTHR13284:SF10 GH01354P SELENOCYSTEINE INSERTION SEQUENCE-BINDING PROTEIN 2-LIKE binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;ribonucleoprotein complex binding#GO:0043021;RNA binding#GO:0003723;protein-containing complex binding#GO:0044877;mRNA 3'-UTR binding#GO:0003730 ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=3799|UniProtKB=Q99853 Q99853 FOXB1 PTHR11829:SF209 FORKHEAD BOX PROTEIN FORKHEAD BOX PROTEIN B1 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;developmental process#GO:0032502;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;cellular process#GO:0009987;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 helix-turn-helix transcription factor#PC00116;gene-specific transcriptional regulator#PC00264;winged helix/forkhead transcription factor#PC00246 HUMAN|HGNC=21897|UniProtKB=Q8N2E2 Q8N2E2 VWDE PTHR14949:SF53 EGF-LIKE-DOMAIN, MULTIPLE 7, 8 VON WILLEBRAND FACTOR D AND EGF DOMAIN-CONTAINING PROTEIN protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165;cell surface#GO:0009986 intercellular signal molecule#PC00207 HUMAN|HGNC=9832|UniProtKB=P55895 P55895 RAG2 PTHR10960:SF0 V D J RECOMBINATION-ACTIVATING PROTEIN 2 V(D)J RECOMBINATION-ACTIVATING PROTEIN 2 sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;nucleic acid binding#GO:0003676;binding#GO:0005488 nucleobase-containing compound metabolic process#GO:0006139;somatic cell DNA recombination#GO:0016444;multicellular organismal process#GO:0032501;cellular process#GO:0009987;multicellular organism development#GO:0007275;macromolecule metabolic process#GO:0043170;DNA recombination#GO:0006310;developmental process#GO:0032502;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;somatic diversification of immune receptors#GO:0002200;V(D)J recombination#GO:0033151;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;system development#GO:0048731;immune system development#GO:0002520;anatomical structure development#GO:0048856;somatic diversification of immune receptors via germline recombination within a single locus#GO:0002562;immune system process#GO:0002376;animal gross anatomical part developmental process#GO:0160108 protein-containing complex#GO:0032991;protein-DNA complex#GO:0032993 HUMAN|HGNC=29036|UniProtKB=Q96H78 Q96H78 SLC25A44 PTHR46314:SF2 SOLUTE CARRIER FAMILY 25 MEMBER 44 SOLUTE CARRIER FAMILY 25 MEMBER 44 transporter activity#GO:0005215;carboxylic acid transmembrane transporter activity#GO:0046943;transmembrane transporter activity#GO:0022857;branched-chain amino acid transmembrane transporter activity#GO:0015658 branched-chain amino acid transport#GO:0015803;establishment of localization#GO:0051234;localization#GO:0051179;organic acid transport#GO:0015849;transport#GO:0006810;carboxylic acid transport#GO:0046942;nitrogen compound transport#GO:0071705 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 transporter#PC00227;secondary carrier transporter#PC00258 HUMAN|HGNC=1312|UniProtKB=O95922 O95922 TTLL1 PTHR12241:SF31 TUBULIN POLYGLUTAMYLASE POLYGLUTAMYLASE COMPLEX SUBUNIT TTLL1 protein binding#GO:0005515;ligase activity, forming carbon-nitrogen bonds#GO:0016879;binding#GO:0005488;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;tubulin binding#GO:0015631;ligase activity#GO:0016874;cytoskeletal protein binding#GO:0008092 gamete generation#GO:0007276;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell development#GO:0048468;cellular process involved in reproduction in multicellular organism#GO:0022412;cilium assembly#GO:0060271;cellular component organization#GO:0016043;sperm motility#GO:0097722;sperm flagellum assembly#GO:0120316;cilium-dependent cell motility#GO:0060285;cilium organization#GO:0044782;spermatid differentiation#GO:0048515;cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;cilium movement involved in cell motility#GO:0060294;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component organization or biogenesis#GO:0071840;motile cilium assembly#GO:0044458;microtubule-based process#GO:0007017;cell motility#GO:0048870;microtubule-based movement#GO:0007018;reproductive process#GO:0022414;developmental process involved in reproduction#GO:0003006;germ cell development#GO:0007281;anatomical structure development#GO:0048856;microtubule cytoskeleton organization#GO:0000226;multicellular organismal reproductive process#GO:0048609;axoneme assembly#GO:0035082;organelle assembly#GO:0070925;microtubule bundle formation#GO:0001578;spermatid development#GO:0007286;sexual reproduction#GO:0019953;male gamete generation#GO:0048232;plasma membrane bounded cell projection organization#GO:0120036;cellular developmental process#GO:0048869;sperm axoneme assembly#GO:0007288;flagellated sperm motility#GO:0030317;plasma membrane bounded cell projection assembly#GO:0120031;developmental process#GO:0032502;spermatogenesis#GO:0007283 cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microtubule cytoskeleton#GO:0015630;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cilium#GO:0005929;microtubule organizing center#GO:0005815;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856 microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=15971|UniProtKB=Q99816 Q99816 TSG101 PTHR23306:SF17 TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED TUMOR SUSCEPTIBILITY GENE 101 PROTEIN binding#GO:0005488;ubiquitin binding#GO:0043130;protein binding#GO:0005515 localization#GO:0051179;vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;cellular process#GO:0009987;transport#GO:0006810 organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;vesicle membrane#GO:0012506;ESCRT I complex#GO:0000813;membrane#GO:0016020;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;intracellular organelle#GO:0043229;endosome#GO:0005768;endosome membrane#GO:0010008;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;vesicle#GO:0031982;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=11312|UniProtKB=P19474 P19474 TRIM21 PTHR24103:SF46 E3 UBIQUITIN-PROTEIN LIGASE TRIM E3 UBIQUITIN-PROTEIN LIGASE TRIM21 aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746 immune system process#GO:0002376;positive regulation of metabolic process#GO:0009893;regulation of biological process#GO:0050789;regulation of autophagy#GO:0010506;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;response to external stimulus#GO:0009605;defense response#GO:0006952;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;regulation of biosynthetic process#GO:0009889;positive regulation of catabolic process#GO:0009896;innate immune response#GO:0045087;positive regulation of biological process#GO:0048518;defense response to symbiont#GO:0140546;immune response#GO:0006955;positive regulation of cellular process#GO:0048522;positive regulation of autophagy#GO:0010508;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;response to other organism#GO:0051707;defense response to other organism#GO:0098542 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=27281|UniProtKB=Q8IY45 Q8IY45 AMN1 PTHR13318:SF254 PARTNER OF PAIRED, ISOFORM B-RELATED PROTEIN AMN1 HOMOLOG primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511 protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;SCF ubiquitin ligase complex#GO:0019005;intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461;transferase complex#GO:1990234;catalytic complex#GO:1902494 HUMAN|HGNC=21153|UniProtKB=Q8TEB7 Q8TEB7 RNF128 PTHR22765:SF30 RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING E3 UBIQUITIN-PROTEIN LIGASE RNF128 ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824 endoplasmic reticulum#GO:0005783;endosome#GO:0005768;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;late endosome#GO:0005770;organelle#GO:0043226 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=24636|UniProtKB=Q9UHB6 Q9UHB6 LIMA1 PTHR24206:SF57 OS06G0237300 PROTEIN LIM DOMAIN AND ACTIN-BINDING PROTEIN 1 binding#GO:0005488;actin filament binding#GO:0051015;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877 cellular component assembly#GO:0022607;actin cytoskeleton organization#GO:0030036;cytoskeleton organization#GO:0007010;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular component organization#GO:0016043;actin filament bundle assembly#GO:0051017;cellular process#GO:0009987;actin filament bundle organization#GO:0061572;cellular component organization or biogenesis#GO:0071840;actin filament organization#GO:0007015;supramolecular fiber organization#GO:0097435;actin filament-based process#GO:0030029 actin cytoskeleton#GO:0015629;membrane#GO:0016020;cell periphery#GO:0071944;organelle#GO:0043226;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=20626|UniProtKB=Q9P2D1 Q9P2D1 CHD7 PTHR45623:SF20 CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED ATP-DEPENDENT CHROMATIN REMODELER CHD7 catalytic activity, acting on DNA#GO:0140097;hydrolase activity, acting on acid anhydrides#GO:0016817;protein binding#GO:0005515;ATP-dependent activity, acting on DNA#GO:0008094;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;ATP-dependent activity#GO:0140657;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;histone binding#GO:0042393;hydrolase activity#GO:0016787;DNA binding#GO:0003677;ATP hydrolysis activity#GO:0016887;nucleic acid binding#GO:0003676;chromatin binding#GO:0003682 ear development#GO:0043583;chordate embryonic development#GO:0043009;animal gross anatomical part developmental process#GO:0160108;circulatory system development#GO:0072359;central nervous system development#GO:0007417;sensory organ morphogenesis#GO:0090596;chromatin remodeling#GO:0006338;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;embryonic morphogenesis#GO:0048598;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;animal organ development#GO:0048513;heart development#GO:0007507;nervous system development#GO:0007399;embryo development#GO:0009790;inner ear morphogenesis#GO:0042472;cellular process#GO:0009987;anatomical structure development#GO:0048856;system development#GO:0048731;embryo development ending in birth or egg hatching#GO:0009792;embryonic organ development#GO:0048568;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;animal organ morphogenesis#GO:0009887;heart morphogenesis#GO:0003007;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;sensory organ development#GO:0007423;developmental process#GO:0032502;multicellular organismal process#GO:0032501;chromatin organization#GO:0006325;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;inner ear development#GO:0048839 intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;chromosome#GO:0005694;chromatin#GO:0000785;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=11767|UniProtKB=O43294 O43294 TGFB1I1 PTHR24216:SF27 PAXILLIN-RELATED TRANSFORMING GROWTH FACTOR BETA-1-INDUCED TRANSCRIPT 1 PROTEIN molecular sequestering activity#GO:0140313;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;protein sequestering activity#GO:0140311;transcription coactivator activity#GO:0003713 anchoring junction#GO:0070161;cell-substrate junction#GO:0030055;focal adhesion#GO:0005925;cellular anatomical structure#GO:0110165;cell junction#GO:0030054;cell-cell junction#GO:0005911 actin or actin-binding cytoskeletal protein#PC00041;cytoskeletal protein#PC00085 Angiogenesis#P00005>Paxillin#P00194;VEGF signaling pathway#P00056>Paxillin#P01418 HUMAN|HGNC=29587|UniProtKB=Q8TAC1 Q8TAC1 RFESD PTHR21496:SF0 FERREDOXIN-RELATED RIESKE DOMAIN-CONTAINING PROTEIN iron-sulfur cluster binding#GO:0051536;binding#GO:0005488;small molecule binding#GO:0036094 oxidoreductase#PC00176 HUMAN|HGNC=24085|UniProtKB=Q9Y5M8 Q9Y5M8 SRPRB PTHR11485:SF34 TRANSFERRIN SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT BETA establishment of protein localization#GO:0045184;protein targeting#GO:0006605;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;localization#GO:0051179;protein targeting to ER#GO:0045047;establishment of protein localization to endoplasmic reticulum#GO:0072599 membrane#GO:0016020;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasm#GO:0005737;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endoplasmic reticulum protein-containing complex#GO:0140534;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane protein complex#GO:0098796;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;rough endoplasmic reticulum#GO:0005791;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;rough endoplasmic reticulum membrane#GO:0030867;intracellular anatomical structure#GO:0005622 transfer/carrier protein#PC00219 HUMAN|HGNC=7572|UniProtKB=Q9UKX2 Q9UKX2 MYH2 PTHR45615:SF39 MYOSIN HEAVY CHAIN, NON-MUSCLE MYOSIN-2 protein-containing complex binding#GO:0044877;protein binding#GO:0005515;actin filament binding#GO:0051015;ATP-dependent activity#GO:0140657;actin binding#GO:0003779;binding#GO:0005488;polypeptide conformation or assembly isomerase activity#GO:0120544;isomerase activity#GO:0016853;cytoskeletal motor activity#GO:0003774;cytoskeletal protein binding#GO:0008092;macromolecular conformation isomerase activity#GO:0120543;microfilament motor activity#GO:0000146;catalytic activity#GO:0003824 multicellular organismal process#GO:0032501;system process#GO:0003008;muscle system process#GO:0003012;muscle contraction#GO:0006936 cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;supramolecular complex#GO:0099080;myosin complex#GO:0016459;actin cytoskeleton#GO:0015629;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 actin or actin-binding cytoskeletal protein#PC00041 Wnt signaling pathway#P00057>NFAT Target Genes#G01559;Cytoskeletal regulation by Rho GTPase#P00016>Myosin#P00522;Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Myosin#P00867 HUMAN|HGNC=14913|UniProtKB=Q9NYW3 Q9NYW3 TAS2R7 PTHR11394:SF58 TASTE RECEPTOR TYPE 2 TASTE RECEPTOR TYPE 2 MEMBER 7 signaling receptor activity#GO:0038023;taste receptor activity#GO:0008527;bitter taste receptor activity#GO:0033038;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 system process#GO:0003008;detection of chemical stimulus involved in sensory perception of bitter taste#GO:0001580;detection of chemical stimulus involved in sensory perception of taste#GO:0050912;nervous system process#GO:0050877;sensory perception#GO:0007600;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of taste#GO:0050909;multicellular organismal process#GO:0032501;response to chemical#GO:0042221;response to stimulus#GO:0050896;detection of chemical stimulus#GO:0009593;sensory perception of bitter taste#GO:0050913;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906 cellular anatomical structure#GO:0110165;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=20073|UniProtKB=Q96L92 Q96L92 SNX27 PTHR12431:SF19 SORTING NEXIN 17 AND 27 SORTING NEXIN-27 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 vesicle-mediated transport#GO:0016192;endocytic recycling#GO:0032456;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;endosomal transport#GO:0016197;vesicle-mediated transport to the plasma membrane#GO:0098876;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;macromolecule metabolic process#GO:0043170;transport#GO:0006810;localization within membrane#GO:0051668;intracellular transport#GO:0046907;metabolic process#GO:0008152 early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708 scaffold/adaptor protein#PC00226 HUMAN|HGNC=1974|UniProtKB=O15111 O15111 CHUK PTHR22969:SF13 IKB KINASE INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674 positive regulation of DNA-templated transcription#GO:0045893;positive regulation of response to stimulus#GO:0048584;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of signal transduction#GO:0009966;positive regulation of RNA biosynthetic process#GO:1902680;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;response to tumor necrosis factor#GO:0034612;regulation of primary metabolic process#GO:0080090;regulation of canonical NF-kappaB signal transduction#GO:0043122;positive regulation of cellular process#GO:0048522;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of macromolecule metabolic process#GO:0060255;regulation of cell communication#GO:0010646;positive regulation of RNA metabolic process#GO:0051254;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;regulation of DNA-templated transcription#GO:0006355;tumor necrosis factor-mediated signaling pathway#GO:0033209;positive regulation of biosynthetic process#GO:0009891;cell communication#GO:0007154;regulation of RNA metabolic process#GO:0051252;cytokine-mediated signaling pathway#GO:0019221;positive regulation of macromolecule metabolic process#GO:0010604;response to chemical#GO:0042221;response to cytokine#GO:0034097;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of canonical NF-kappaB signal transduction#GO:0043123;positive regulation of transcription by RNA polymerase II#GO:0045944;cell surface receptor signaling pathway#GO:0007166;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;signaling#GO:0023052;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;positive regulation of signaling#GO:0023056;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;response to peptide#GO:1901652;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051 transferase complex#GO:1990234;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;protein kinase complex#GO:1902911;serine/threonine protein kinase complex#GO:1902554;cytosol#GO:0005829;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 B cell activation#P00010>IKK#P00397;T cell activation#P00053>IKK#P01330;PDGF signaling pathway#P00047>Ikk#P01146;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>IKK#P00871;Toll receptor signaling pathway#P00054>IKKalpha#P01345;Apoptosis signaling pathway#P00006>IKK#P00313;Interleukin signaling pathway#P00036>Ikk#P00968 HUMAN|HGNC=18914|UniProtKB=A8MVA2 A8MVA2 KRTAP9-6 PTHR23262:SF133 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 9-6-RELATED structural protein#PC00211 HUMAN|HGNC=42970|UniProtKB=Q9H9K5 Q9H9K5 ERVMER34-1 PTHR10424:SF78 VIRAL ENVELOPE PROTEIN ENDOGENOUS RETROVIRAL ENVELOPE PROTEIN HEMO myoblast fusion#GO:0007520;muscle cell differentiation#GO:0042692;cellular process#GO:0009987;cell differentiation#GO:0030154;muscle structure development#GO:0061061;cell-cell fusion#GO:0140253;animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502;syncytium formation by cell-cell fusion#GO:0000768;anatomical structure development#GO:0048856;cellular developmental process#GO:0048869;striated muscle cell differentiation#GO:0051146 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 viral or transposable element protein#PC00237 HUMAN|HGNC=17010|UniProtKB=O15504 O15504 NUP42 PTHR46527:SF1 NUCLEOPORIN-LIKE PROTEIN 2 NUCLEOPORIN NUP42 transporter#PC00227 HUMAN|HGNC=24343|UniProtKB=Q9P0U4 Q9P0U4 CXXC1 PTHR46174:SF1 CXXC-TYPE ZINC FINGER PROTEIN 1 CXXC-TYPE ZINC FINGER PROTEIN 1 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 organelle#GO:0043226;nucleoplasm#GO:0005654;methyltransferase complex#GO:0034708;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;Set1C/COMPASS complex#GO:0048188;transferase complex#GO:1990234;histone methyltransferase complex#GO:0035097 HUMAN|HGNC=7974|UniProtKB=Q9Y5X4 Q9Y5X4 NR2E3 PTHR24083:SF4 NUCLEAR HORMONE RECEPTOR PHOTORECEPTOR-SPECIFIC NUCLEAR RECEPTOR sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023;transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;molecular transducer activity#GO:0060089;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;nuclear receptor activity#GO:0004879;transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676 regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of cellular process#GO:0048522;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;developmental process#GO:0032502;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of biological process#GO:0050789;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;positive regulation of macromolecule metabolic process#GO:0010604;nervous system development#GO:0007399;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;multicellular organism development#GO:0007275;positive regulation of transcription by RNA polymerase II#GO:0045944;neuron differentiation#GO:0030182 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C4 zinc finger nuclear receptor#PC00169;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=5988|UniProtKB=Q13478 Q13478 IL18R1 PTHR11890:SF6 INTERLEUKIN-1 RECEPTOR FAMILY MEMBER INTERLEUKIN-18 RECEPTOR 1 cytokine receptor activity#GO:0004896;transmembrane signaling receptor activity#GO:0004888;immune receptor activity#GO:0140375;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 response to peptide#GO:1901652;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;immune system process#GO:0002376;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;positive regulation of multicellular organismal process#GO:0051240;cell surface receptor signaling pathway#GO:0007166;regulation of multicellular organismal process#GO:0051239;positive regulation of macromolecule metabolic process#GO:0010604;response to cytokine#GO:0034097;response to chemical#GO:0042221;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;cell communication#GO:0007154;positive regulation of biosynthetic process#GO:0009891;cytokine-mediated signaling pathway#GO:0019221;regulation of macromolecule metabolic process#GO:0060255;positive regulation of cytokine production#GO:0001819;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;adaptive immune response#GO:0002250;positive regulation of cellular process#GO:0048522;immune response#GO:0006955;regulation of cytokine production#GO:0001817;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=13576|UniProtKB=Q5SWL7 Q5SWL7 PRAMEF14 PTHR14224:SF81 SIMILAR TO PREFERENTIALLY EXPRESSED ANTIGEN IN MELANOMA-LIKE 3 PRAME FAMILY MEMBER 1-RELATED ubiquitin-like ligase-substrate adaptor activity#GO:1990756;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;enzyme-substrate adaptor activity#GO:0140767 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941 ubiquitin ligase complex#GO:0000151;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;Cul2-RING ubiquitin ligase complex#GO:0031462;transferase complex#GO:1990234;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;cullin-RING ubiquitin ligase complex#GO:0031461 HUMAN|HGNC=32259|UniProtKB=A0A8V8TNH8 A0A8V8TNH8 FAM90A11 PTHR16035:SF14 PROTEIN FAM90A1 PROTEIN FAM90A10-RELATED HUMAN|HGNC=16687|UniProtKB=Q9NRA8 Q9NRA8 EIF4ENIF1 PTHR12269:SF1 EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TRANSPORTER EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TRANSPORTER transporter#PC00227 HUMAN|HGNC=30091|UniProtKB=Q96QH2 Q96QH2 PRAM1 PTHR16830:SF11 SH2 CONTAINING ADAPTOR PRAM-1 RELATED PML-RARA-REGULATED ADAPTER MOLECULE 1 positive regulation of immune system process#GO:0002684;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;signal transduction#GO:0007165;antigen receptor-mediated signaling pathway#GO:0050851;protein localization to cell periphery#GO:1990778;cell surface receptor signaling pathway#GO:0007166;immune response-activating signaling pathway#GO:0002757;integrin-mediated signaling pathway#GO:0007229;protein localization to membrane#GO:0072657;immune response-regulating signaling pathway#GO:0002764;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signaling#GO:0023052;immune system process#GO:0002376;cellular localization#GO:0051641;macromolecule localization#GO:0033036;positive regulation of response to stimulus#GO:0048584;immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007;T cell receptor signaling pathway#GO:0050852;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;intracellular protein localization#GO:0008104;protein localization to plasma membrane#GO:0072659;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;immune response-activating cell surface receptor signaling pathway#GO:0002429;regulation of immune response#GO:0050776;localization within membrane#GO:0051668;cell communication#GO:0007154;localization#GO:0051179 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=9042|UniProtKB=Q13018 Q13018 PLA2R1 PTHR22803:SF74 MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED SECRETORY PHOSPHOLIPASE A2 RECEPTOR transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 transport#GO:0006810;receptor-mediated endocytosis#GO:0006898;localization#GO:0051179;establishment of localization#GO:0051234;import into cell#GO:0098657;cellular process#GO:0009987;endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192 cell periphery#GO:0071944;signaling receptor complex#GO:0043235;membrane#GO:0016020;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=6746|UniProtKB=Q14596 Q14596 NBR1 PTHR20930:SF2 OVARIAN CARCINOMA ANTIGEN CA125-RELATED NEXT TO BRCA1 GENE 1 PROTEIN metabolic process#GO:0008152;intracellular transport#GO:0046907;vacuolar transport#GO:0007034;transport#GO:0006810;intracellular protein transport#GO:0006886;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;protein targeting to vacuole#GO:0006623;establishment of protein localization#GO:0045184;autophagy#GO:0006914;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macroautophagy#GO:0016236;protein localization to vacuole#GO:0072665;localization#GO:0051179;cellular localization#GO:0051641;protein transport#GO:0015031;process utilizing autophagic mechanism#GO:0061919;catabolic process#GO:0009056;establishment of protein localization to vacuole#GO:0072666;protein localization to organelle#GO:0033365;protein targeting#GO:0006605 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;vacuole#GO:0005773;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;autophagosome#GO:0005776 HUMAN|HGNC=28283|UniProtKB=Q6UXU4 Q6UXU4 GSG1L PTHR10671:SF35 EPITHELIAL MEMBRANE PROTEIN-RELATED GERM CELL-SPECIFIC GENE 1-LIKE PROTEIN regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of receptor-mediated endocytosis#GO:0048259;regulation of cellular component organization#GO:0051128;regulation of cell communication#GO:0010646;modulation of chemical synaptic transmission#GO:0050804;regulation of signaling#GO:0023051;regulation of biological quality#GO:0065008;regulation of trans-synaptic signaling#GO:0099177;biological regulation#GO:0065007;regulation of synaptic plasticity#GO:0048167;regulation of endocytosis#GO:0030100;regulation of neuronal synaptic plasticity#GO:0048168;regulation of localization#GO:0032879;regulation of transport#GO:0051049 synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;asymmetric synapse#GO:0032279;postsynapse#GO:0098794;postsynaptic density membrane#GO:0098839;postsynaptic density#GO:0014069;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;plasma membrane#GO:0005886;neuron to neuron synapse#GO:0098984;plasma membrane region#GO:0098590;postsynaptic specialization#GO:0099572;cell periphery#GO:0071944;membrane#GO:0016020;cell junction#GO:0030054;synaptic membrane#GO:0097060 cytoskeletal protein#PC00085 HUMAN|HGNC=23337|UniProtKB=Q8NC06 Q8NC06 ACBD4 PTHR23310:SF53 ACYL-COA-BINDING PROTEIN, ACBP ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 4 binding#GO:0005488;small molecule binding#GO:0036094;anion binding#GO:0043168;ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265;lipid binding#GO:0008289;heterocyclic compound binding#GO:1901363 small molecule metabolic process#GO:0044281;cellular process#GO:0009987;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;fatty acid metabolic process#GO:0006631 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 transfer/carrier protein#PC00219 HUMAN|HGNC=9509|UniProtKB=P49810 P49810 PSEN2 PTHR10202:SF24 PRESENILIN PRESENILIN-2 catalytic activity#GO:0003824;aspartic-type endopeptidase activity#GO:0004190;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;homeostatic process#GO:0042592;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;protein metabolic process#GO:0019538;proteolysis#GO:0006508;calcium ion homeostasis#GO:0055074;inorganic ion homeostasis#GO:0098771;membrane protein ectodomain proteolysis#GO:0006509;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;biological regulation#GO:0065007;monoatomic ion homeostasis#GO:0050801;signal transduction#GO:0007165;membrane protein proteolysis#GO:0033619;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein processing#GO:0016485;macromolecule metabolic process#GO:0043170;Notch signaling pathway#GO:0007219;metabolic process#GO:0008152;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;cell surface receptor signaling pathway#GO:0007166 catalytic complex#GO:1902494;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 aspartic protease#PC00053;protease#PC00190 Alzheimer disease-presenilin pathway#P00004>Presenilin N-terminal fragment#P00140;Alzheimer disease-amyloid secretase pathway#P00003>Presenilin C-terminal fragment#P00102;Alzheimer disease-amyloid secretase pathway#P00003>Presenilin#P00098;Alzheimer disease-amyloid secretase pathway#P00003>Presenilin N-terminal fragment#P00088;Alzheimer disease-presenilin pathway#P00004>Presenilin C-terminal fragment#P00155;Notch signaling pathway#P00045>Pen-2#P01113;Alzheimer disease-presenilin pathway#P00004>Presenilin#P00129 HUMAN|HGNC=9571|UniProtKB=Q92530 Q92530 PSMF1 PTHR13266:SF1 PROTEASOME INHIBITOR PROTEASOME INHIBITOR PI31 SUBUNIT negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;negative regulation of protein catabolic process#GO:0042177;regulation of proteasomal protein catabolic process#GO:0061136;negative regulation of cellular process#GO:0048523;regulation of catabolic process#GO:0009894;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;negative regulation of proteasomal protein catabolic process#GO:1901799;negative regulation of protein metabolic process#GO:0051248;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of catabolic process#GO:0009895;regulation of protein catabolic process#GO:0042176 protein-binding activity modulator#PC00095;protease inhibitor#PC00191 HUMAN|HGNC=30249|UniProtKB=Q6ZRP7 Q6ZRP7 QSOX2 PTHR22897:SF7 QUIESCIN Q6-RELATED SULFHYDRYL OXIDASE SULFHYDRYL OXIDASE 2 oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;catalytic activity#GO:0003824;disulfide oxidoreductase activity#GO:0015036;oxidoreductase activity#GO:0016491;catalytic activity, acting on a protein#GO:0140096;protein-disulfide reductase activity#GO:0015035 primary metabolic process#GO:0044238;cellular component organization#GO:0016043;protein folding#GO:0006457;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198;protein metabolic process#GO:0019538;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;biosynthetic process#GO:0009058;cellular component assembly#GO:0022607;gene expression#GO:0010467;extracellular matrix assembly#GO:0085029;protein maturation#GO:0051604;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 oxidoreductase#PC00176;oxidase#PC00175 HUMAN|HGNC=14051|UniProtKB=P82932 P82932 MRPS6 PTHR21011:SF17 MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S6 SMALL RIBOSOMAL SUBUNIT PROTEIN BS6M structural constituent of ribosome#GO:0003735;binding#GO:0005488;rRNA binding#GO:0019843;nucleic acid binding#GO:0003676;structural molecule activity#GO:0005198;RNA binding#GO:0003723 mitochondrion#GO:0005739;ribosome#GO:0005840;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;small ribosomal subunit#GO:0015935;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;mitochondrial ribosome#GO:0005761;organellar ribosome#GO:0000313;intracellular anatomical structure#GO:0005622;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;membraneless organelle#GO:0043228;mitochondrial small ribosomal subunit#GO:0005763 ribosomal protein#PC00202;translational protein#PC00263 HUMAN|HGNC=26521|UniProtKB=Q8IVV2 Q8IVV2 LOXHD1 PTHR45901:SF8 PROTEIN CBG12474 LIPOXYGENASE HOMOLOGY DOMAIN-CONTAINING PROTEIN 1 sensory perception of mechanical stimulus#GO:0050954;sensory perception#GO:0007600;nervous system process#GO:0050877;sensory perception of sound#GO:0007605;multicellular organismal process#GO:0032501;system process#GO:0003008 cluster of actin-based cell projections#GO:0098862;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;stereocilium#GO:0032420;cytoskeleton#GO:0005856;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;neuron projection#GO:0043005;actin-based cell projection#GO:0098858;actin cytoskeleton#GO:0015629 HUMAN|HGNC=4655|UniProtKB=P32780 P32780 GTF2H1 PTHR12856:SF0 TRANSCRIPTION INITIATION FACTOR IIH-RELATED GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 1 RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;DNA repair#GO:0006281;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;DNA metabolic process#GO:0006259;transcription by RNA polymerase II#GO:0006366;DNA damage response#GO:0006974;gene expression#GO:0010467;nucleotide-excision repair#GO:0006289;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;response to stress#GO:0006950;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 cyclin-dependent protein kinase holoenzyme complex#GO:0000307;protein-containing complex#GO:0032991;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;RNA polymerase II transcription regulator complex#GO:0090575;transcription regulator complex#GO:0005667;intracellular protein-containing complex#GO:0140535;protein kinase complex#GO:1902911;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234;transcription factor TFIIH core complex#GO:0000439;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;RNA polymerase II, holoenzyme#GO:0016591;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;transcription factor TFIIH holo complex#GO:0005675 general transcription factor#PC00259;RNA metabolism protein#PC00031 Transcription regulation by bZIP transcription factor#P00055>TFIIH complex#P01392;General transcription regulation#P00023>TFIIH complex#P00664 HUMAN|HGNC=727|UniProtKB=Q5T4W7 Q5T4W7 ARTN PTHR12173:SF9 GDNF SUBFAMILY OF TGF-BETA FAMILY ARTEMIN molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;growth factor activity#GO:0008083 biological regulation#GO:0065007;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;multicellular organismal process#GO:0032501;signal transduction#GO:0007165;cellular process#GO:0009987;neuron projection development#GO:0031175;neurogenesis#GO:0022008;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;developmental process#GO:0032502;neuron differentiation#GO:0030182;cell surface receptor signaling pathway#GO:0007166;signaling#GO:0023052;cell development#GO:0048468;cell projection organization#GO:0030030;response to stimulus#GO:0050896;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular component organization#GO:0016043;system development#GO:0048731;neuron development#GO:0048666;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207;growth factor#PC00112;neurotrophic factor#PC00163 HUMAN|HGNC=26015|UniProtKB=Q59GN2 Q59GN2 RPL39P5 PTHR19970:SF36 RIBOSOMAL PROTEIN L39E RIBOSOMAL PROTEIN EL39-LIKE 5-RELATED structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 metabolic process#GO:0008152;translation#GO:0006412;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cytoplasmic translation#GO:0002181;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;biosynthetic process#GO:0009058 cytosolic ribosome#GO:0022626;cytosolic large ribosomal subunit#GO:0022625;cytosol#GO:0005829;ribosome#GO:0005840;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202 HUMAN|HGNC=28097|UniProtKB=Q96A19 Q96A19 CCDC102A PTHR46292:SF3 COILED-COIL DOMAIN-CONTAINING PROTEIN 102A COILED-COIL DOMAIN-CONTAINING PROTEIN 102A HUMAN|HGNC=14257|UniProtKB=Q8N6Y1 Q8N6Y1 PCDH20 PTHR24028:SF260 CADHERIN-87A PROTOCADHERIN-20 cellular process#GO:0009987;cell adhesion#GO:0007155 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 cell adhesion molecule#PC00069;cadherin#PC00057 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HUMAN|HGNC=18130|UniProtKB=Q8IZU3 Q8IZU3 SYCP3 PTHR19368:SF12 XLR/SCP3/FAM9 SYNAPTONEMAL COMPLEX PROTEIN 3 cellular process#GO:0009987;male gamete generation#GO:0048232;developmental process#GO:0032502;spermatogenesis#GO:0007283;meiotic cell cycle#GO:0051321;cellular developmental process#GO:0048869;germ cell development#GO:0007281;developmental process involved in reproduction#GO:0003006;cell cycle#GO:0007049;reproductive process#GO:0022414;cell development#GO:0048468;cellular process involved in reproduction in multicellular organism#GO:0022412;gamete generation#GO:0007276;cell differentiation#GO:0030154;spermatid development#GO:0007286;sexual reproduction#GO:0019953;spermatid differentiation#GO:0048515;multicellular organismal reproductive process#GO:0048609;anatomical structure development#GO:0048856 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;chromosome#GO:0005694;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;condensed chromosome#GO:0000793;membraneless organelle#GO:0043228;synaptonemal complex#GO:0000795;condensed nuclear chromosome#GO:0000794;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;synaptonemal structure#GO:0099086;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228 HUMAN|HGNC=30338|UniProtKB=Q7Z5B4 Q7Z5B4 RIC3 PTHR21723:SF3 RESISTANCE TO INHIBITORS OF CHOLINESTERASE PROTEIN 3 RIC3 PROTEIN RIC-3 anterograde trans-synaptic signaling#GO:0098916;synaptic transmission, cholinergic#GO:0007271;signaling#GO:0023052;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;chemical synaptic transmission#GO:0007268;synaptic signaling#GO:0099536;macromolecule localization#GO:0033036;cellular process#GO:0009987;regulation of biological process#GO:0050789;localization#GO:0051179;cell communication#GO:0007154;intracellular protein localization#GO:0008104;trans-synaptic signaling#GO:0099537 cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;neuron projection#GO:0043005;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 HUMAN|HGNC=910|UniProtKB=P25311 P25311 AZGP1 PTHR16675:SF289 MHC CLASS I-RELATED ZINC-ALPHA-2-GLYCOPROTEIN regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;positive regulation of leukocyte mediated immunity#GO:0002705;positive regulation of immune effector process#GO:0002699;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;immune response#GO:0006955;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of immune system process#GO:0002684;regulation of leukocyte mediated cytotoxicity#GO:0001910;regulation of immune effector process#GO:0002697;antigen processing and presentation#GO:0019882;positive regulation of lymphocyte mediated immunity#GO:0002708;regulation of cell killing#GO:0031341;regulation of immune response#GO:0050776;regulation of lymphocyte mediated immunity#GO:0002706;immune system process#GO:0002376;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;response to stimulus#GO:0050896;positive regulation of adaptive immune response#GO:0002821;regulation of biological process#GO:0050789;regulation of leukocyte mediated immunity#GO:0002703 cellular anatomical structure#GO:0110165;cell surface#GO:0009986;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;side of membrane#GO:0098552;extracellular region#GO:0005576;external side of plasma membrane#GO:0009897 major histocompatibility complex protein#PC00149;defense/immunity protein#PC00090 HUMAN|HGNC=28976|UniProtKB=Q14679 Q14679 TTLL4 PTHR12241:SF162 TUBULIN POLYGLUTAMYLASE TUBULIN MONOGLUTAMYLASE TTLL4 catalytic activity#GO:0003824;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;ligase activity#GO:0016874;catalytic activity, acting on a protein#GO:0140096;binding#GO:0005488;protein binding#GO:0005515;ligase activity, forming carbon-nitrogen bonds#GO:0016879 cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;cytoskeleton organization#GO:0007010;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226 membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;ciliary basal body#GO:0036064;intracellular organelle#GO:0043229;cilium#GO:0005929;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;plasma membrane bounded cell projection#GO:0120025;microtubule cytoskeleton#GO:0015630 microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=12369|UniProtKB=Q96PP4 Q96PP4 TSGA13 PTHR37352:SF1 TESTIS-SPECIFIC GENE 13 PROTEIN TESTIS-SPECIFIC GENE 13 PROTEIN HUMAN|HGNC=17291|UniProtKB=Q13445 Q13445 TMED1 PTHR22811:SF40 TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN 1 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;cargo adaptor activity#GO:0140312 endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;protein transport#GO:0015031;localization#GO:0051179;cellular localization#GO:0051641;Golgi organization#GO:0007030;cellular component organization#GO:0016043;Golgi vesicle transport#GO:0048193;intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;organelle organization#GO:0006996;macromolecule localization#GO:0033036;endomembrane system organization#GO:0010256;vesicle-mediated transport#GO:0016192 Golgi apparatus#GO:0005794;endoplasmic reticulum#GO:0005783;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;COPII-coated ER to Golgi transport vesicle#GO:0030134;cytoplasmic vesicle#GO:0031410;coated vesicle#GO:0030135;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 membrane traffic protein#PC00150;vesicle coat protein#PC00235 HUMAN|HGNC=3735|UniProtKB=O43638 O43638 FOXS1 PTHR11829:SF370 FORKHEAD BOX PROTEIN FORKHEAD BOX PROTEIN S1 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 developmental process#GO:0032502;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 helix-turn-helix transcription factor#PC00116;winged helix/forkhead transcription factor#PC00246;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=1937|UniProtKB=P35790 P35790 CHKA PTHR22603:SF36 CHOLINE/ETHANOALAMINE KINASE CHOLINE KINASE ALPHA phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824 lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474;metabolic process#GO:0008152;phosphatidylcholine biosynthetic process#GO:0006656;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;glycerophospholipid metabolic process#GO:0006650;phosphatidylcholine metabolic process#GO:0046470;glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;organophosphate biosynthetic process#GO:0090407;phospholipid metabolic process#GO:0006644;phospholipid biosynthetic process#GO:0008654;glycerolipid metabolic process#GO:0046486;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 kinase#PC00137 HUMAN|HGNC=31689|UniProtKB=Q6ZN16 Q6ZN16 MAP3K15 PTHR11584:SF363 SERINE/THREONINE PROTEIN KINASE MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 15 catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;MAP kinase kinase kinase activity#GO:0004709 intracellular signal transduction#GO:0035556;MAPK cascade#GO:0000165;cell communication#GO:0007154;intracellular signaling cassette#GO:0141124;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;JNK cascade#GO:0007254;p38MAPK cascade#GO:0038066;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=25545|UniProtKB=Q4KMZ1 Q4KMZ1 IQCC PTHR16049:SF8 IQ DOMAIN-CONTAINING PROTEIN C IQ DOMAIN-CONTAINING PROTEIN C HUMAN|HGNC=10698|UniProtKB=Q92503 Q92503 SEC14L1 PTHR23324:SF51 SEC14 RELATED PROTEIN SEC14-LIKE PROTEIN 1 binding#GO:0005488;signaling receptor binding#GO:0005102;protein binding#GO:0005515 regulation of response to external stimulus#GO:0032101;negative regulation of response to stimulus#GO:0048585;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of immune system process#GO:0002683;negative regulation of signal transduction#GO:0009968;regulation of innate immune response#GO:0045088;regulation of response to stress#GO:0080134;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of response to biotic stimulus#GO:0002831;regulation of cell communication#GO:0010646;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;regulation of immune response#GO:0050776;regulation of signaling#GO:0023051;regulation of defense response#GO:0031347 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 transfer/carrier protein#PC00219 HUMAN|HGNC=30871|UniProtKB=Q9UBM8 Q9UBM8 MGAT4C PTHR12062:SF14 N-ACETYLGLUCOSAMINYLTRANSFERASE VI ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 4-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE C hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;catalytic activity#GO:0003824;acetylglucosaminyltransferase activity#GO:0008375;glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194 macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;biosynthetic process#GO:0009058;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 transferase#PC00220 HUMAN|HGNC=16806|UniProtKB=O95071 O95071 UBR5 PTHR46276:SF1 E3 UBIQUITIN-PROTEIN LIGASE UBR5 E3 UBIQUITIN-PROTEIN LIGASE UBR5 ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824 regulation of signaling#GO:0023051;protein modification by small protein conjugation or removal#GO:0070647;positive regulation of signaling#GO:0023056;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;protein modification process#GO:0036211;primary metabolic process#GO:0044238;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of response to stimulus#GO:0048583;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;positive regulation of canonical Wnt signaling pathway#GO:0090263;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of canonical Wnt signaling pathway#GO:0060828;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;positive regulation of response to stimulus#GO:0048584;positive regulation of Wnt signaling pathway#GO:0030177 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 ubiquitin-protein ligase#PC00234 Hedgehog signaling pathway#P00025>Ubiquitin ligase#P00693 HUMAN|HGNC=16961|UniProtKB=Q15762 Q15762 CD226 PTHR47011:SF1 CD226 ANTIGEN CD226 ANTIGEN cell adhesion molecule binding#GO:0050839;binding#GO:0005488;protein binding#GO:0005515 positive regulation of immune system process#GO:0002684;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of response to stimulus#GO:0048584;positive regulation of immune effector process#GO:0002699;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of leukocyte mediated immunity#GO:0002705;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;positive regulation of signal transduction#GO:0009967;regulation of leukocyte mediated immunity#GO:0002703;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;positive regulation of cell communication#GO:0010647;positive regulation of adaptive immune response#GO:0002821;regulation of cell communication#GO:0010646;regulation of lymphocyte mediated immunity#GO:0002706;regulation of signaling#GO:0023051;regulation of immune response#GO:0050776;regulation of immune effector process#GO:0002697;positive regulation of signaling#GO:0023056;positive regulation of lymphocyte mediated immunity#GO:0002708 plasma membrane#GO:0005886;cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020 HUMAN|Ensembl=ENSG00000280987|UniProtKB=A0A0R4J2E8 A0A0R4J2E8 MATR3 PTHR15592:SF2 MATRIN 3/NUCLEAR PROTEIN 220-RELATED MATRIN-3 RNA binding#GO:0003723;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of RNA splicing#GO:0043484;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 RNA processing factor#PC00147 HUMAN|HGNC=23780|UniProtKB=Q5JVG8 Q5JVG8 ZNF506 PTHR24384:SF180 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED ZINC FINGER PROTEIN 506 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218 HUMAN|HGNC=16990|UniProtKB=O00193 O00193 SMAP PTHR22175:SF1 SMALL ACIDIC PROTEIN-RELATED SMALL ACIDIC PROTEIN nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=12557|UniProtKB=Q96PU4 Q96PU4 UHRF2 PTHR14140:SF3 E3 UBIQUITIN-PROTEIN LIGASE UHRF-RELATED E3 UBIQUITIN-PROTEIN LIGASE UHRF2 transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659 chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;protein modification by small protein conjugation#GO:0032446;regulation of biological process#GO:0050789;protein modification by small protein conjugation or removal#GO:0070647;protein ubiquitination#GO:0016567;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;negative regulation of gene expression, epigenetic#GO:0045814;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;protein modification process#GO:0036211;primary metabolic process#GO:0044238;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;post-translational protein modification#GO:0043687;negative regulation of biosynthetic process#GO:0009890;chromatin organization#GO:0006325;biological regulation#GO:0065007;epigenetic regulation of gene expression#GO:0040029;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=14723|UniProtKB=Q8NGS4 Q8NGS4 OR13F1 PTHR26453:SF562 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 13F1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;response to chemical#GO:0042221;response to stimulus#GO:0050896;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;detection of chemical stimulus#GO:0009593;system process#GO:0003008;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;nervous system process#GO:0050877;sensory perception#GO:0007600 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=19964|UniProtKB=Q7L8A9 Q7L8A9 VASH1 PTHR15750:SF5 VASOHIBIN-1-LIKE ISOFORM X2 TUBULINYL-TYR CARBOXYPEPTIDASE 1 regulation of biological process#GO:0050789;regulation of multicellular organismal development#GO:2000026;biological regulation#GO:0065007;regulation of developmental process#GO:0050793;regulation of multicellular organismal process#GO:0051239;regulation of vasculature development#GO:1901342;regulation of anatomical structure morphogenesis#GO:0022603;regulation of angiogenesis#GO:0045765 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=12632|UniProtKB=Q93008 Q93008 USP9X PTHR24006:SF897 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 9X peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity, acting on a protein#GO:0140096;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;cysteine-type deubiquitinase activity#GO:0004843;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005 cell motility#GO:0048870;cell migration#GO:0016477;regulation of biological quality#GO:0065008;biological regulation#GO:0065007;cellular process#GO:0009987;regulation of protein stability#GO:0031647 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;cytosol#GO:0005829 protease#PC00190;cysteine protease#PC00081 HUMAN|HGNC=250|UniProtKB=P00325 P00325 ADH1B PTHR43880:SF1 ALCOHOL DEHYDROGENASE ALL-TRANS-RETINOL DEHYDROGENASE [NAD(+)] ADH1B oxidoreductase activity#GO:0016491;alcohol dehydrogenase (NAD+) activity#GO:0004022;catalytic activity#GO:0003824;zinc ion binding#GO:0008270;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;all-trans-retinol dehydrogenase (NAD+) activity#GO:0004745;cation binding#GO:0043169;metal ion binding#GO:0046872;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;transition metal ion binding#GO:0046914;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455 lipid metabolic process#GO:0006629;retinoid metabolic process#GO:0001523;diterpenoid metabolic process#GO:0016101;hormone metabolic process#GO:0042445;aldehyde catabolic process#GO:0046185;biological regulation#GO:0065007;retinol metabolic process#GO:0042572;terpenoid metabolic process#GO:0006721;isoprenoid metabolic process#GO:0006720;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;response to toxic substance#GO:0009636;catabolic process#GO:0009056;alcohol metabolic process#GO:0006066;metabolic process#GO:0008152;aldehyde metabolic process#GO:0006081;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;response to chemical#GO:0042221;cellular response to toxic substance#GO:0097237;detoxification#GO:0098754;olefinic compound metabolic process#GO:0120254;cellular response to chemical stimulus#GO:0070887;oxoacid metabolic process#GO:0043436;cellular detoxification#GO:1990748;response to oxygen-containing compound#GO:1901700;regulation of biological quality#GO:0065008;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;cellular detoxification of aldehyde#GO:0110095;regulation of hormone levels#GO:0010817;response to stimulus#GO:0050896;small molecule metabolic process#GO:0044281;small molecule catabolic process#GO:0044282 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 dehydrogenase#PC00092 HUMAN|HGNC=4682|UniProtKB=Q02747 Q02747 GUCA2A PTHR11318:SF3 GUANYLIN FAMILY MEMBER GUANYLIN enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047;cyclase regulator activity#GO:0010851 protein-binding activity modulator#PC00095 HUMAN|HGNC=8543|UniProtKB=Q15077 Q15077 P2RY6 PTHR24231:SF16 PURINOCEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR P2Y PURINOCEPTOR 6 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987;response to chemical#GO:0042221;cellular response to nitrogen compound#GO:1901699;biological regulation#GO:0065007;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;response to oxygen-containing compound#GO:1901700;cell communication#GO:0007154;response to nitrogen compound#GO:1901698;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=12284|UniProtKB=A0A0A0MS02 A0A0A0MS02 TRGV1 PTHR19256:SF48 T-CELL RECEPTOR GAMMA CHAIN NON-FUNCTIONAL T CELL RECEPTOR GAMMA VARIABLE-RELATED immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=1020|UniProtKB=Q9Y276 Q9Y276 BCS1L PTHR23070:SF255 BCS1 AAA-TYPE ATPASE MITOCHONDRIAL CHAPERONE BCS1 protein localization to organelle#GO:0033365;protein-containing complex assembly#GO:0065003;protein localization to mitochondrion#GO:0070585;cellular component organization#GO:0016043;localization#GO:0051179;cellular localization#GO:0051641;localization within membrane#GO:0051668;membrane organization#GO:0061024;mitochondrial respiratory chain complex III assembly#GO:0034551;mitochondrial respiratory chain complex assembly#GO:0033108;mitochondrion organization#GO:0007005;protein insertion into membrane#GO:0051205;cellular component assembly#GO:0022607;mitochondrial membrane organization#GO:0007006;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;inner mitochondrial membrane organization#GO:0007007;macromolecule localization#GO:0033036;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;establishment of protein localization to membrane#GO:0090150;intracellular protein localization#GO:0008104;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;cytochrome complex assembly#GO:0017004 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=29507|UniProtKB=Q9HB40 Q9HB40 SCPEP1 PTHR11802:SF3 SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE RETINOID-INDUCIBLE SERINE CARBOXYPEPTIDASE serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;carboxypeptidase activity#GO:0004180;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233 serine protease#PC00203 HUMAN|HGNC=24297|UniProtKB=Q5TAG4 Q5TAG4 NBPF12 PTHR14199:SF35 NEUROBLASTOMA BREAKPOINT FAMILY MEMBER 6-LIKE PROTEIN NBPF FAMILY MEMBER NBPF1-RELATED HUMAN|HGNC=33251|UniProtKB=A6NN92 A6NN92 GJE1 PTHR11984:SF1 CONNEXIN GAP JUNCTION EPSILON-1 PROTEIN transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;passive transmembrane transporter activity#GO:0022803;channel activity#GO:0015267;wide pore channel activity#GO:0022829 cell communication#GO:0007154;signaling#GO:0023052;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;regulation of biological process#GO:0050789;cellular process#GO:0009987 cell junction#GO:0030054;anchoring junction#GO:0070161;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane#GO:0016020;cell-cell junction#GO:0005911;membrane protein complex#GO:0098796;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797 cell junction protein#PC00070;gap junction#PC00105 HUMAN|HGNC=14215|UniProtKB=Q9BYV6 Q9BYV6 TRIM55 PTHR24103:SF640 E3 UBIQUITIN-PROTEIN LIGASE TRIM TRIPARTITE MOTIF-CONTAINING PROTEIN 55 catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630 response to biotic stimulus#GO:0009607;response to stress#GO:0006950;defense response to symbiont#GO:0140546;immune response#GO:0006955;response to stimulus#GO:0050896;defense response to other organism#GO:0098542;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to other organism#GO:0051707;immune system process#GO:0002376;innate immune response#GO:0045087;response to external stimulus#GO:0009605;defense response#GO:0006952 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=30382|UniProtKB=Q0VDG4 Q0VDG4 SCRN3 PTHR12994:SF18 SECERNIN SECERNIN-3 HUMAN|HGNC=20249|UniProtKB=Q7Z699 Q7Z699 SPRED1 PTHR11202:SF18 SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN 1 protein kinase binding#GO:0019901;enzyme binding#GO:0019899;binding#GO:0005488;kinase binding#GO:0019900;protein binding#GO:0005515 regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;negative regulation of biological process#GO:0048519;negative regulation of MAPK cascade#GO:0043409;regulation of biological process#GO:0050789;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;negative regulation of response to stimulus#GO:0048585;regulation of ERK1 and ERK2 cascade#GO:0070372;negative regulation of ERK1 and ERK2 cascade#GO:0070373;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of MAPK cascade#GO:0043408 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HUMAN|HGNC=4172|UniProtKB=P23771 P23771 GATA3 PTHR10071:SF106 TRANSCRIPTION FACTOR GATA FAMILY MEMBER TRANS-ACTING T-CELL-SPECIFIC TRANSCRIPTION FACTOR GATA-3 cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 positive regulation of transcription by RNA polymerase II#GO:0045944;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;animal organ development#GO:0048513;multicellular organism development#GO:0007275;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of epithelial cell differentiation#GO:0030856;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604;embryo development#GO:0009790;regulation of multicellular organismal process#GO:0051239;animal gross anatomical part developmental process#GO:0160108;immune system process#GO:0002376;immune system development#GO:0002520;negative regulation of DNA-templated transcription#GO:0045892;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;cell fate commitment#GO:0045165;negative regulation of biological process#GO:0048519;regulation of multicellular organismal development#GO:2000026;regulation of biological process#GO:0050789;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;negative regulation of cellular process#GO:0048523;regulation of cell differentiation#GO:0045595;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;positive regulation of DNA-templated transcription#GO:0045893;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;positive regulation of RNA biosynthetic process#GO:1902680;embryonic organ development#GO:0048568;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;system development#GO:0048731;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;regulation of developmental process#GO:0050793 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218 HUMAN|HGNC=25404|UniProtKB=Q4VC44 Q4VC44 FLYWCH1 PTHR31665:SF3 FLYWCH FAMILY MEMBER 2-RELATED FLYWCH-TYPE ZINC FINGER-CONTAINING PROTEIN 1 HUMAN|HGNC=25829|UniProtKB=Q6UWZ7 Q6UWZ7 ABRAXAS1 PTHR31728:SF2 ABRAXAS FAMILY MEMBER BRCA1-A COMPLEX SUBUNIT ABRAXAS 1 tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;polyubiquitin modification-dependent protein binding#GO:0031593;modification-dependent protein binding#GO:0140030;binding#GO:0005488;microtubule binding#GO:0008017;protein binding#GO:0005515 mitotic sister chromatid segregation#GO:0000070;mitotic spindle assembly#GO:0090307;spindle organization#GO:0007051;chromosome organization#GO:0051276;mitotic cell cycle process#GO:1903047;mitotic cell cycle#GO:0000278;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cell cycle#GO:0007049;microtubule cytoskeleton organization#GO:0000226;organelle fission#GO:0048285;localization#GO:0051179;organelle localization#GO:0051640;organelle assembly#GO:0070925;cellular component assembly#GO:0022607;chromosome localization#GO:0050000;cytoskeleton organization#GO:0007010;attachment of spindle microtubules to kinetochore#GO:0008608;spindle assembly#GO:0051225;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;metaphase chromosome alignment#GO:0051310;chromosome segregation#GO:0007059;mitotic spindle organization#GO:0007052;membraneless organelle assembly#GO:0140694;sister chromatid segregation#GO:0000819;nuclear chromosome segregation#GO:0098813;cellular component organization#GO:0016043;mitotic nuclear division#GO:0140014;cell cycle process#GO:0022402;nuclear division#GO:0000280 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=43617|UniProtKB=A6NNH2 A6NNH2 FAM90A27P PTHR16035:SF17 PROTEIN FAM90A1 PROTEIN FAM90A27P HUMAN|HGNC=9839|UniProtKB=P11233 P11233 RALA PTHR24070:SF174 RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY RAS-RELATED PROTEIN RAL-A hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787 cellular process#GO:0009987;signal transduction#GO:0007165;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;regulation of transport#GO:0051049;regulation of localization#GO:0032879;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;Ras protein signal transduction#GO:0007265;regulation of exocytosis#GO:0017157;regulation of secretion by cell#GO:1903530;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;regulation of secretion#GO:0051046 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 small GTPase#PC00208 Ras Pathway#P04393>Ral#P04550 HUMAN|HGNC=24666|UniProtKB=Q96CS3 Q96CS3 FAF2 PTHR23322:SF1 FAS-ASSOCIATED PROTEIN FAS-ASSOCIATED FACTOR 2 protein binding#GO:0005515;ubiquitin binding#GO:0043130;binding#GO:0005488 primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;catabolic process#GO:0009056;response to endoplasmic reticulum stress#GO:0034976;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;ERAD pathway#GO:0036503;response to stress#GO:0006950;cellular process#GO:0009987;response to chemical#GO:0042221;proteasomal protein catabolic process#GO:0010498;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 scaffold/adaptor protein#PC00226 HUMAN|HGNC=8976|UniProtKB=P42338 P42338 PIK3CB PTHR10048:SF33 PHOSPHATIDYLINOSITOL KINASE PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphatidylinositol kinase activity#GO:0052742;catalytic activity#GO:0003824;transferase activity#GO:0016740;lipid kinase activity#GO:0001727;phosphotransferase activity, alcohol group as acceptor#GO:0016773 metabolic process#GO:0008152;glycerophospholipid biosynthetic process#GO:0046474;lipid metabolic process#GO:0006629;organophosphate metabolic process#GO:0019637;signal transduction#GO:0007165;phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0043491;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;glycerophospholipid metabolic process#GO:0006650;cell migration#GO:0016477;lipid biosynthetic process#GO:0008610;biological regulation#GO:0065007;biosynthetic process#GO:0009058;intracellular signaling cassette#GO:0141124;phosphatidylinositol phosphate biosynthetic process#GO:0046854;cell communication#GO:0007154;organophosphate biosynthetic process#GO:0090407;intracellular signal transduction#GO:0035556;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;glycerolipid metabolic process#GO:0046486;regulation of cellular process#GO:0050794;phospholipid biosynthetic process#GO:0008654;cell motility#GO:0048870;phospholipid metabolic process#GO:0006644;signaling#GO:0023052 membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;plasma membrane#GO:0005886;transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;transferase complex#GO:1990234;extrinsic component of membrane#GO:0019898;intracellular anatomical structure#GO:0005622 kinase#PC00137 Endothelin signaling pathway#P00019>PI3K#P00577;p53 pathway#P00059>PI3K#P04609;PDGF signaling pathway#P00047>PI3K#P01168;Apoptosis signaling pathway#P00006>PI3K#P00310;Ras Pathway#P04393>PI3K#P04567;Hypoxia response via HIF activation#P00030>PI3K#P00823;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>PI3K#P00900;Interleukin signaling pathway#P00036>PI3K#P00990;p53 pathway feedback loops 2#P04398>PI3K#P04661;Axon guidance mediated by netrin#P00009>PI3K#P00363;Integrin signalling pathway#P00034>PI3K#P00936;Angiogenesis#P00005>PI3K#P00236;EGF receptor signaling pathway#P00018>PI3K#P00557;FGF signaling pathway#P00021>PI3K#P00640;B cell activation#P00010>PI3K#P00391;CCKR signaling map#P06959>p110#P07020;T cell activation#P00053>PI3K#P01322;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PI3K#P00868;PI3 kinase pathway#P00048>P110ACT#P01177;VEGF signaling pathway#P00056>PI3K#P01413;PI3 kinase pathway#P00048>p110#P01192 HUMAN|HGNC=5351|UniProtKB=Q9Y6W8 Q9Y6W8 ICOS PTHR20904:SF0 INDUCIBLE T-CELL COSTIMULATOR ICOS INDUCIBLE T-CELL COSTIMULATOR positive regulation of leukocyte activation#GO:0002696;multicellular organism development#GO:0007275;positive regulation of cell-cell adhesion#GO:0022409;cell-cell adhesion#GO:0098609;positive regulation of immune system process#GO:0002684;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of T cell activation#GO:0050870;regulation of T cell activation#GO:0050863;regulation of multicellular organismal process#GO:0051239;immune system process#GO:0002376;animal gross anatomical part developmental process#GO:0160108;cell adhesion#GO:0007155;immune system development#GO:0002520;regulation of leukocyte activation#GO:0002694;regulation of biological process#GO:0050789;regulation of cell activation#GO:0050865;positive regulation of multicellular organismal process#GO:0051240;regulation of lymphocyte activation#GO:0051249;regulation of leukocyte cell-cell adhesion#GO:1903037;developmental process#GO:0032502;positive regulation of cellular process#GO:0048522;multicellular organismal process#GO:0032501;regulation of cell adhesion#GO:0030155;positive regulation of leukocyte cell-cell adhesion#GO:1903039;biological regulation#GO:0065007;positive regulation of cell activation#GO:0050867;positive regulation of lymphocyte activation#GO:0051251;anatomical structure development#GO:0048856;system development#GO:0048731;positive regulation of cell adhesion#GO:0045785;regulation of immune system process#GO:0002682;regulation of cell-cell adhesion#GO:0022407;regulation of cellular process#GO:0050794 HUMAN|HGNC=25851|UniProtKB=Q9BRX5 Q9BRX5 GINS3 PTHR22768:SF0 DNA REPLICATION COMPLEX GINS PROTEIN PSF3 DNA REPLICATION COMPLEX GINS PROTEIN PSF3 macromolecule metabolic process#GO:0043170;DNA-templated DNA replication#GO:0006261;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;DNA replication initiation#GO:0006270;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular process#GO:0009987;DNA replication#GO:0006260 membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;chromosome#GO:0005694;organelle lumen#GO:0043233;DNA replication preinitiation complex#GO:0031261;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;protein-DNA complex#GO:0032993;GINS complex#GO:0000811;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=25201|UniProtKB=Q86XT9 Q86XT9 TMEM219 PTHR16002:SF6 TRANSMEMBRANE PROTEIN 248-LIKE INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 3 RECEPTOR HUMAN|HGNC=30009|UniProtKB=Q9UBV8 Q9UBV8 PEF1 PTHR46212:SF10 PEFLIN PEFLIN endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;localization#GO:0051179;COPII-coated vesicle budding#GO:0090114;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;vesicle organization#GO:0016050;vesicle budding from membrane#GO:0006900;protein-containing complex organization#GO:0043933;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;Golgi vesicle transport#GO:0048193;transport#GO:0006810;intracellular transport#GO:0046907;membrane organization#GO:0061024;vesicle-mediated transport#GO:0016192;cellular component assembly#GO:0022607;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996 HUMAN|HGNC=33480|UniProtKB=Q4G0S4 Q4G0S4 CYP27C1 PTHR24291:SF9 CYTOCHROME P450 FAMILY 4 CYTOCHROME P450 27C1 lipid binding#GO:0008289;organic acid binding#GO:0043177;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;anion binding#GO:0043168;carboxylic acid binding#GO:0031406;alcohol binding#GO:0043178;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 oxidoreductase#PC00176;oxygenase#PC00177;metabolite interconversion enzyme#PC00262 Vitamin D metabolism and pathway#P04396>1alpha-Hydroxylase#P04603 HUMAN|HGNC=27548|UniProtKB=Q9NX77 Q9NX77 ERVK13-1 PTHR34313:SF3 ENDOGENOUS RETROVIRUS GROUP K MEMBER 113 ENV POLYPROTEIN-RELATED ENDOGENOUS RETROVIRUS GROUP K MEMBER 113 ENV POLYPROTEIN-RELATED viral or transposable element protein#PC00237 HUMAN|HGNC=7208|UniProtKB=O75970 O75970 MPDZ PTHR19964:SF10 MULTIPLE PDZ DOMAIN PROTEIN MULTIPLE PDZ DOMAIN PROTEIN cellular component assembly#GO:0022607;cell junction organization#GO:0034330;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;cell junction assembly#GO:0034329;cellular component organization#GO:0016043;cellular component organization or biogenesis#GO:0071840;cell-cell junction organization#GO:0045216;cell-cell junction assembly#GO:0007043 intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;tight junction#GO:0070160;cell junction#GO:0030054;apical part of cell#GO:0045177;apical junction complex#GO:0043296;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;bicellular tight junction#GO:0005923;cell periphery#GO:0071944;membrane#GO:0016020;cell-cell junction#GO:0005911 scaffold/adaptor protein#PC00226 HUMAN|HGNC=30708|UniProtKB=P0C7X1 P0C7X1 TBC1D3H PTHR22957:SF571 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN TBC1 DOMAIN FAMILY MEMBER 3-RELATED enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772 GTPase-activating protein#PC00257;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HUMAN|HGNC=6695|UniProtKB=O75074 O75074 LRP3 PTHR24270:SF22 LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 3 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 apolipoprotein#PC00052;transfer/carrier protein#PC00219 Alzheimer disease-presenilin pathway#P00004>LRP C-terminal fragment#P00112;Alzheimer disease-presenilin pathway#P00004>LRP N-terminal fragment#P00169;Alzheimer disease-presenilin pathway#P00004>LRP intracellular fragment#P00173;Alzheimer disease-presenilin pathway#P00004>LRP transmembrane fragment#P00152;Alzheimer disease-presenilin pathway#P00004>LRP#P00150 HUMAN|HGNC=1772|UniProtKB=Q00526 Q00526 CDK3 PTHR24056:SF462 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE 3 cyclin-dependent protein kinase activity#GO:0097472;protein serine/threonine kinase activity#GO:0004674;cyclin-dependent protein serine/threonine kinase activity#GO:0004693;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096 mitotic cell cycle process#GO:1903047;cellular process#GO:0009987;signal transduction#GO:0007165;cell cycle G2/M phase transition#GO:0044839;biological regulation#GO:0065007;mitotic cell cycle phase transition#GO:0044772;cell communication#GO:0007154;cell cycle process#GO:0022402;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cell cycle#GO:0007049;signaling#GO:0023052;regulation of cellular process#GO:0050794;G2/M transition of mitotic cell cycle#GO:0000086;cell cycle phase transition#GO:0044770;response to stimulus#GO:0050896;mitotic cell cycle#GO:0000278 intracellular anatomical structure#GO:0005622;protein kinase complex#GO:1902911;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=34300|UniProtKB=A4D1F6 A4D1F6 LRRD1 PTHR48051:SF49 FAMILY NOT NAMED LEUCINE-RICH REPEAT AND DEATH DOMAIN-CONTAINING PROTEIN 1 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=16381|UniProtKB=Q5SGD2 Q5SGD2 PPM1L PTHR13832:SF827 PROTEIN PHOSPHATASE 2C PROTEIN PHOSPHATASE 1L phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787 cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007 protein phosphatase#PC00195 HUMAN|HGNC=753|UniProtKB=P08243 P08243 ASNS PTHR11772:SF36 ASPARAGINE SYNTHETASE ASPARAGINE SYNTHETASE [GLUTAMINE-HYDROLYZING] ligase activity, forming carbon-nitrogen bonds#GO:0016879;ligase activity#GO:0016874;catalytic activity#GO:0003824 small molecule biosynthetic process#GO:0044283;amino acid biosynthetic process#GO:0008652;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;proteinogenic amino acid biosynthetic process#GO:0170038;cellular process#GO:0009987;aspartate family amino acid biosynthetic process#GO:0009067;carboxylic acid biosynthetic process#GO:0046394;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;amino acid metabolic process#GO:0006520;biosynthetic process#GO:0009058;proteinogenic amino acid metabolic process#GO:0170039;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 ligase#PC00142 Asparagine and aspartate biosynthesis#P02730>Asparagine synthetase#P02853 HUMAN|HGNC=43788|UniProtKB=Q8NHM4 Q8NHM4 PRSS3P2 PTHR24264:SF64 TRYPSIN-RELATED TRYPSIN-6-RELATED serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175 proteolysis#GO:0006508;metabolic process#GO:0008152;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease#PC00190;serine protease#PC00203 HUMAN|HGNC=11546|UniProtKB=Q15543 Q15543 TAF13 PTHR11380:SF17 TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 13 nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;transcription by RNA polymerase II#GO:0006366;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;DNA-templated transcription#GO:0006351;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA biosynthetic process#GO:0032774 transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;transcription regulator complex#GO:0005667;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;membrane-enclosed lumen#GO:0031974;RNA polymerase II transcription regulator complex#GO:0090575;transcription factor TFIID complex#GO:0005669;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;membrane-bounded organelle#GO:0043227;RNA polymerase II, holoenzyme#GO:0016591;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654 general transcription factor#PC00259 HUMAN|HGNC=4894|UniProtKB=Q04756 Q04756 HGFAC PTHR24264:SF43 TRYPSIN-RELATED HEPATOCYTE GROWTH FACTOR ACTIVATOR SERINE PROTEASE serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;serine-type peptidase activity#GO:0008236 wound healing#GO:0042060;regulation of biological quality#GO:0065008;protein metabolic process#GO:0019538;proteolysis#GO:0006508;response to stimulus#GO:0050896;regulation of body fluid levels#GO:0050878;zymogen activation#GO:0031638;hemostasis#GO:0007599;primary metabolic process#GO:0044238;blood coagulation#GO:0007596;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;biological regulation#GO:0065007;biosynthetic process#GO:0009058;multicellular organismal process#GO:0032501;protein maturation#GO:0051604;gene expression#GO:0010467;coagulation#GO:0050817;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein processing#GO:0016485;response to wounding#GO:0009611;response to stress#GO:0006950 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 serine protease#PC00203;protease#PC00190 HUMAN|HGNC=2454|UniProtKB=Q9HCP0 Q9HCP0 CSNK1G1 PTHR11909:SF156 CASEIN KINASE-RELATED CASEIN KINASE I ISOFORM GAMMA-1 protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824 cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 membrane#GO:0016020;cell periphery#GO:0071944;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 Wnt signaling pathway#P00057>Casein Kinase 1#P01460;Parkinson disease#P00049>Casein kinase I#P01242 HUMAN|HGNC=6326|UniProtKB=Q9BVG8 Q9BVG8 KIFC3 PTHR47972:SF5 KINESIN-LIKE PROTEIN KLP-3 KINESIN-LIKE PROTEIN KIFC3 cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;microtubule binding#GO:0008017;binding#GO:0005488;protein binding#GO:0005515 cellular process#GO:0009987;microtubule-based process#GO:0007017 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 microtubule binding motor protein#PC00156 HUMAN|HGNC=17009|UniProtKB=Q9H2D6 Q9H2D6 TRIOBP PTHR17271:SF10 PLECKSTRIN HOMOLOGY PH DOMAIN-CONTAINING PROTEIN TRIO AND F-ACTIN-BINDING PROTEIN binding#GO:0005488;actin filament binding#GO:0051015;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877 positive regulation of cell adhesion#GO:0045785;positive regulation of cell-substrate adhesion#GO:0010811;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789;regulation of cell adhesion#GO:0030155;regulation of cellular process#GO:0050794;regulation of cell-substrate adhesion#GO:0010810;biological regulation#GO:0065007 intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;actin cytoskeleton#GO:0015629;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 actin or actin-binding cytoskeletal protein#PC00041;cytoskeletal protein#PC00085 HUMAN|HGNC=2191|UniProtKB=Q05707 Q05707 COL14A1 PTHR24020:SF15 COLLAGEN ALPHA COLLAGEN ALPHA-1(XIV) CHAIN extracellular structure organization#GO:0043062;cellular component organization#GO:0016043;cellular process#GO:0009987;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;external encapsulating structure organization#GO:0045229 extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;interstitial matrix#GO:0005614;cellular anatomical structure#GO:0110165 extracellular matrix structural protein#PC00103 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>EMC#P00863;Integrin signalling pathway#P00034>Collagen#P00922 HUMAN|HGNC=9812|UniProtKB=P54725 P54725 RAD23A PTHR10621:SF29 UV EXCISION REPAIR PROTEIN RAD23 LYSINE-SPECIFIC DEMETHYLASE RAD23A ubiquitin binding#GO:0043130;binding#GO:0005488;modification-dependent protein binding#GO:0140030;polyubiquitin modification-dependent protein binding#GO:0031593;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;cytosol#GO:0005829;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 damaged DNA-binding protein#PC00086;DNA metabolism protein#PC00009 HUMAN|HGNC=22921|UniProtKB=Q9BXI2 Q9BXI2 SLC25A2 PTHR45624:SF20 MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED MITOCHONDRIAL ORNITHINE TRANSPORTER 2 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;amino acid transmembrane transporter activity#GO:0015171;L-amino acid transmembrane transporter activity#GO:0015179 carboxylic acid transmembrane transport#GO:1905039;mitochondrial transport#GO:0006839;L-alpha-amino acid transmembrane transport#GO:1902475;transmembrane transport#GO:0055085;cellular localization#GO:0051641;amino acid transmembrane transport#GO:0003333;localization#GO:0051179;mitochondrial transmembrane transport#GO:1990542;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;nitrogen compound transport#GO:0071705;L-amino acid transport#GO:0015807;establishment of localization#GO:0051234;carboxylic acid transport#GO:0046942;transport#GO:0006810;amino acid transport#GO:0006865;organic acid transport#GO:0015849;intracellular transport#GO:0046907 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739 transporter#PC00227 HUMAN|HGNC=20647|UniProtKB=Q8TF45 Q8TF45 ZNF418 PTHR24377:SF759 IP01015P-RELATED ZINC FINGER PROTEIN 418 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=10564|UniProtKB=O15127 O15127 SCAMP2 PTHR10687:SF7 SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN SCAMP SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN 2 secretion by cell#GO:0032940;exocytosis#GO:0006887;localization#GO:0051179;secretion#GO:0046903;establishment of localization#GO:0051234;transport#GO:0006810;export from cell#GO:0140352;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987 recycling endosome membrane#GO:0055038;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;Golgi apparatus#GO:0005794;recycling endosome#GO:0055037;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;trans-Golgi network membrane#GO:0032588;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;vesicle membrane#GO:0012506;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;endosome membrane#GO:0010008;endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular vesicle#GO:0097708 transfer/carrier protein#PC00219 HUMAN|HGNC=10078|UniProtKB=Q9H4A4 Q9H4A4 RNPEP PTHR45726:SF1 LEUKOTRIENE A-4 HYDROLASE AMINOPEPTIDASE B metalloaminopeptidase activity#GO:0070006;hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;metallopeptidase activity#GO:0008237;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;aminopeptidase activity#GO:0004177;catalytic activity#GO:0003824;metalloexopeptidase activity#GO:0008235 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;primary metabolic process#GO:0044238;proteolysis#GO:0006508;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=18352|UniProtKB=Q9NSP4 Q9NSP4 CENPM PTHR34436:SF1 CENTROMERE PROTEIN M CENTROMERE PROTEIN M membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687;condensed chromosome#GO:0000793;chromosome, centromeric region#GO:0000775;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694;condensed chromosome, centromeric region#GO:0000779;kinetochore#GO:0000776 HUMAN|HGNC=678|UniProtKB=P52565 P52565 ARHGDIA PTHR10980:SF9 RHO GDP-DISSOCIATION INHIBITOR RHO GDP-DISSOCIATION INHIBITOR 1 molecular function regulator activity#GO:0098772;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234 Rho protein signal transduction#GO:0007266;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;intracellular signaling cassette#GO:0141124;signaling#GO:0023052;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007 membrane#GO:0016020;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HUMAN|HGNC=5232|UniProtKB=P0DMV8 P0DMV8 HSPA1A PTHR19375:SF223 HEAT SHOCK PROTEIN 70KDA HEAT SHOCK 70 KDA PROTEIN 1A-RELATED hydrolase activity#GO:0016787;protein binding#GO:0005515;ATP hydrolysis activity#GO:0016887;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;ATP-dependent activity#GO:0140657;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;heat shock protein binding#GO:0031072;hydrolase activity, acting on acid anhydrides#GO:0016817 positive regulation of proteasomal protein catabolic process#GO:1901800;regulation of biological process#GO:0050789;protein folding#GO:0006457;positive regulation of protein metabolic process#GO:0051247;positive regulation of metabolic process#GO:0009893;protein refolding#GO:0042026;regulation of protein metabolic process#GO:0051246;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;protein maturation#GO:0051604;gene expression#GO:0010467;positive regulation of macromolecule metabolic process#GO:0010604;regulation of proteasomal protein catabolic process#GO:0061136;positive regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032436;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;metabolic process#GO:0008152;primary metabolic process#GO:0044238;positive regulation of ubiquitin-dependent protein catabolic process#GO:2000060;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;protein metabolic process#GO:0019538;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434;regulation of protein catabolic process#GO:0042176;positive regulation of protein catabolic process#GO:0045732;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;macromolecule biosynthetic process#GO:0009059;positive regulation of cellular process#GO:0048522;biological regulation#GO:0065007;biosynthetic process#GO:0009058;positive regulation of catabolic process#GO:0009896;macromolecule metabolic process#GO:0043170;regulation of catabolic process#GO:0009894 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 Hsp70 family chaperone#PC00027;chaperone#PC00072 Apoptosis signaling pathway#P00006>HSP70#P00321;Parkinson disease#P00049>Hsp70#P01208;Gonadotropin-releasing hormone receptor pathway#P06664>miR-132/212#G06683 HUMAN|HGNC=23197|UniProtKB=Q9NQW1 Q9NQW1 SEC31B PTHR13923:SF22 SEC31-RELATED PROTEIN PROTEIN TRANSPORT PROTEIN SEC31B cellular component organization#GO:0016043;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;localization#GO:0051179;COPII-coated vesicle budding#GO:0090114;membrane organization#GO:0061024;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;organelle organization#GO:0006996;vesicle budding from membrane#GO:0006900;vesicle organization#GO:0016050;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;transport#GO:0006810;Golgi vesicle transport#GO:0048193;intracellular transport#GO:0046907 intracellular organelle#GO:0043229;coated membrane#GO:0048475;COPII-coated ER to Golgi transport vesicle#GO:0030134;membrane coat#GO:0030117;membrane-bounded organelle#GO:0043227;coated vesicle#GO:0030135;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;coated vesicle membrane#GO:0030662;intracellular membrane-bounded organelle#GO:0043231;ER to Golgi transport vesicle membrane#GO:0012507;endoplasmic reticulum exit site#GO:0070971;endoplasmic reticulum#GO:0005783;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;vesicle membrane#GO:0012506;membrane#GO:0016020;transport vesicle#GO:0030133;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;transport vesicle membrane#GO:0030658;protein-containing complex#GO:0032991;vesicle coat#GO:0030120;cytoplasm#GO:0005737 vesicle coat protein#PC00235;membrane traffic protein#PC00150 HUMAN|HGNC=7869|UniProtKB=O60936 O60936 NOL3 PTHR22797:SF37 CARD6/NUCLEOLAR PROTEIN 3 NUCLEOLAR PROTEIN 3 HUMAN|HGNC=29877|UniProtKB=Q14157 Q14157 UBAP2L PTHR16308:SF18 UBIQUITIN ASSOCIATED PROTEIN 2-LIKE/LINGERER UBIQUITIN-ASSOCIATED PROTEIN 2-LIKE cellular component organization or biogenesis#GO:0071840;multicellular organismal-level homeostasis#GO:0048871;organelle assembly#GO:0070925;homeostasis of number of cells#GO:0048872;cytoplasmic stress granule assembly#GO:0034063;multicellular organismal process#GO:0032501;cellular component assembly#GO:0022607;homeostatic process#GO:0042592;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;PcG protein complex#GO:0031519 HUMAN|HGNC=28042|UniProtKB=A4D1B5 A4D1B5 GSAP PTHR13630:SF1 GAMMA-SECRETASE-ACTIVATING PROTEIN GAMMA-SECRETASE-ACTIVATING PROTEIN positive regulation of metabolic process#GO:0009893;positive regulation of protein metabolic process#GO:0051247;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of macromolecule metabolic process#GO:0010604;regulation of biological process#GO:0050789;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 Golgi apparatus subcompartment#GO:0098791;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984 protein-binding activity modulator#PC00095 HUMAN|HGNC=3098|UniProtKB=O14656 O14656 TOR1A PTHR10760:SF15 TORSIN TORSIN-1A binding#GO:0005488;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515 protein localization to organelle#GO:0033365;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;cellular component organization#GO:0016043;protein localization to nucleus#GO:0034504;organelle organization#GO:0006996;macromolecule localization#GO:0033036;cellular process#GO:0009987;nuclear membrane organization#GO:0071763;nucleus organization#GO:0006997;cellular component organization or biogenesis#GO:0071840;localization#GO:0051179;nuclear envelope organization#GO:0006998;intracellular protein localization#GO:0008104 endoplasmic reticulum#GO:0005783;nucleus#GO:0005634;endoplasmic reticulum lumen#GO:0005788;membrane-enclosed lumen#GO:0031974;nuclear envelope#GO:0005635;cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle envelope#GO:0031967;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 chaperone#PC00072 Parkinson disease#P00049>Torsin A#P01221 HUMAN|HGNC=25312|UniProtKB=Q6UWH4 Q6UWH4 GASK1B PTHR15905:SF1 GOLGI-ASSOCIATED KINASE 1B-RELATED GOLGI-ASSOCIATED KINASE 1B HUMAN|HGNC=20075|UniProtKB=P62068 P62068 USP46 PTHR24006:SF714 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 46 deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;cysteine-type deubiquitinase activity#GO:0004843;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233 regulation of protein stability#GO:0031647;biological regulation#GO:0065007;regulation of biological quality#GO:0065008 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 protease#PC00190;cysteine protease#PC00081 HUMAN|HGNC=450|UniProtKB=Q9H161 Q9H161 ALX4 PTHR24329:SF322 HOMEOBOX PROTEIN ARISTALESS HOMEOBOX PROTEIN ARISTALESS-LIKE 4 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;DNA-binding transcription activator activity#GO:0001216;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=4281|UniProtKB=P48165 P48165 GJA8 PTHR11984:SF19 CONNEXIN GAP JUNCTION ALPHA-8 PROTEIN channel activity#GO:0015267;wide pore channel activity#GO:0022829;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;passive transmembrane transporter activity#GO:0022803 cell-cell signaling#GO:0007267;signaling#GO:0023052;biological regulation#GO:0065007;regulation of biological process#GO:0050789;cellular process#GO:0009987;localization#GO:0051179;cell communication#GO:0007154;establishment of localization#GO:0051234;transport#GO:0006810 plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane#GO:0016020;cell-cell junction#GO:0005911;membrane protein complex#GO:0098796;anchoring junction#GO:0070161;cell junction#GO:0030054 gap junction#PC00105;cell junction protein#PC00070 HUMAN|HGNC=34427|UniProtKB=Q68DQ2 Q68DQ2 CRYBG3 PTHR11818:SF38 BETA/GAMMA CRYSTALLIN VERY LARGE A-KINASE ANCHOR PROTEIN structural molecule activity#GO:0005198 multicellular organismal process#GO:0032501;sensory system development#GO:0048880;system process#GO:0003008;multicellular organism development#GO:0007275;animal organ development#GO:0048513;lens development in camera-type eye#GO:0002088;developmental process#GO:0032502;sensory organ development#GO:0007423;visual system development#GO:0150063;visual perception#GO:0007601;sensory perception of light stimulus#GO:0050953;system development#GO:0048731;eye development#GO:0001654;anatomical structure development#GO:0048856;sensory perception#GO:0007600;nervous system process#GO:0050877;camera-type eye development#GO:0043010;animal gross anatomical part developmental process#GO:0160108 structural protein#PC00211 HUMAN|HGNC=29114|UniProtKB=O94868 O94868 FCHSD2 PTHR15735:SF11 FCH AND DOUBLE SH3 DOMAINS PROTEIN F-BAR AND DOUBLE SH3 DOMAINS PROTEIN 2 lipid binding#GO:0008289;phosphatidylinositol bisphosphate binding#GO:1902936;binding#GO:0005488;anion binding#GO:0043168;small molecule binding#GO:0036094;phosphatidylinositol-4,5-bisphosphate binding#GO:0005546;ion binding#GO:0043167;phosphatidylinositol phosphate binding#GO:1901981;phospholipid binding#GO:0005543 anterograde trans-synaptic signaling#GO:0098916;regulation of cytoskeleton organization#GO:0051493;regulation of protein polymerization#GO:0032271;regulation of cellular process#GO:0050794;chemical synaptic transmission#GO:0007268;regulation of supramolecular fiber organization#GO:1902903;clathrin-dependent endocytosis#GO:0072583;cell communication#GO:0007154;localization#GO:0051179;trans-synaptic signaling#GO:0099537;regulation of actin filament polymerization#GO:0030833;membrane organization#GO:0061024;regulation of actin polymerization or depolymerization#GO:0008064;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;regulation of actin filament organization#GO:0110053;establishment of localization#GO:0051234;receptor-mediated endocytosis#GO:0006898;regulation of actin filament-based process#GO:0032970;transport#GO:0006810;regulation of cellular component organization#GO:0051128;endocytosis#GO:0006897;signaling#GO:0023052;regulation of cellular component biogenesis#GO:0044087;regulation of protein-containing complex assembly#GO:0043254;cellular component organization#GO:0016043;regulation of cellular component size#GO:0032535;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;regulation of biological quality#GO:0065008;regulation of actin filament length#GO:0030832;vesicle-mediated transport#GO:0016192;regulation of actin cytoskeleton organization#GO:0032956;synaptic signaling#GO:0099536;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;import into cell#GO:0098657;regulation of anatomical structure size#GO:0090066;neuromuscular synaptic transmission#GO:0007274 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;synapse#GO:0045202;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768;plasma membrane#GO:0005886;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cell periphery#GO:0071944;membrane#GO:0016020;cell junction#GO:0030054;neuromuscular junction#GO:0031594;recycling endosome#GO:0055037 non-motor actin binding protein#PC00165;cytoskeletal protein#PC00085 HUMAN|HGNC=3233|UniProtKB=Q7Z7M0 Q7Z7M0 MEGF8 PTHR23244:SF511 KELCH REPEAT DOMAIN MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN 8 cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 HUMAN|HGNC=20380|UniProtKB=Q8NEX5 Q8NEX5 WFDC9 PTHR19441:SF16 WAP four-disulfide core domain protein PROTEIN WFDC9 enzyme regulator activity#GO:0030234;serine-type endopeptidase inhibitor activity#GO:0004867;molecular function inhibitor activity#GO:0140678;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414;peptidase regulator activity#GO:0061134;endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772;enzyme inhibitor activity#GO:0004857 antimicrobial humoral response#GO:0019730;humoral immune response#GO:0006959;antibacterial humoral response#GO:0019731;innate immune response#GO:0045087;defense response#GO:0006952;response to external stimulus#GO:0009605;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;immune response#GO:0006955;defense response to symbiont#GO:0140546;defense response to other organism#GO:0098542;response to other organism#GO:0051707;immune system process#GO:0002376;response to bacterium#GO:0009617;defense response to bacterium#GO:0042742;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease inhibitor#PC00191 HUMAN|HGNC=11045|UniProtKB=P48065 P48065 SLC6A12 PTHR11616:SF118 SODIUM/CHLORIDE DEPENDENT TRANSPORTER SODIUM- AND CHLORIDE-DEPENDENT BETAINE TRANSPORTER transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;monoatomic anion transmembrane transporter activity#GO:0008509;amino acid transmembrane transporter activity#GO:0015171;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;symporter activity#GO:0015293;monoatomic cation transmembrane transporter activity#GO:0008324;transmembrane transporter activity#GO:0022857;chloride transmembrane transporter activity#GO:0015108;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;solute:monoatomic cation symporter activity#GO:0015294;carboxylic acid transmembrane transporter activity#GO:0046943;amino acid:sodium symporter activity#GO:0005283;solute:sodium symporter activity#GO:0015370 amino acid transport#GO:0006865;transport#GO:0006810;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic ion transport#GO:0006811;sodium ion transmembrane transport#GO:0035725;sodium ion transport#GO:0006814;cellular process#GO:0009987;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220 plasma membrane#GO:0005886;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 primary active transporter#PC00068 HUMAN|HGNC=31988|UniProtKB=Q5VWK0 Q5VWK0 NBPF6 PTHR14199:SF29 NEUROBLASTOMA BREAKPOINT FAMILY MEMBER 6-LIKE PROTEIN NBPF FAMILY MEMBER NBPF4-RELATED HUMAN|HGNC=21919|UniProtKB=Q9H0J9 Q9H0J9 PARP12 PTHR45740:SF6 POLY [ADP-RIBOSE] POLYMERASE PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP12 transferase activity#GO:0016740;catalytic activity#GO:0003824;NAD+ poly-ADP-ribosyltransferase activity#GO:0003950;pentosyltransferase activity#GO:0016763;catalytic activity, acting on a protein#GO:0140096;glycosyltransferase activity#GO:0016757 cellular process#GO:0009987;protein modification process#GO:0036211;primary metabolic process#GO:0044238;post-translational protein modification#GO:0043687;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=15558|UniProtKB=Q8WYQ4 Q8WYQ4 C22orf15 PTHR33887:SF1 PB1 DOMAIN-CONTAINING PROTEIN GENE 867-RELATED HUMAN|HGNC=2085|UniProtKB=P04118 P04118 CLPS PTHR10041:SF8 COLIPASE COLIPASE enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772 protein-binding activity modulator#PC00095 HUMAN|HGNC=37250|UniProtKB=B6A8C7 B6A8C7 TARM1 PTHR11738:SF157 MHC CLASS I NK CELL RECEPTOR T-CELL-INTERACTING, ACTIVATING RECEPTOR ON MYELOID CELLS PROTEIN 1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 negative regulation of T cell proliferation#GO:0042130;regulation of leukocyte proliferation#GO:0070663;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of mononuclear cell proliferation#GO:0032944;negative regulation of lymphocyte activation#GO:0051250;negative regulation of leukocyte activation#GO:0002695;regulation of multicellular organismal process#GO:0051239;regulation of T cell activation#GO:0050863;negative regulation of cell-cell adhesion#GO:0022408;regulation of cell activation#GO:0050865;regulation of biological process#GO:0050789;regulation of leukocyte activation#GO:0002694;negative regulation of biological process#GO:0048519;regulation of lymphocyte activation#GO:0051249;signaling#GO:0023052;response to stimulus#GO:0050896;negative regulation of cellular process#GO:0048523;regulation of leukocyte cell-cell adhesion#GO:1903037;negative regulation of cell activation#GO:0050866;negative regulation of cell population proliferation#GO:0008285;biological regulation#GO:0065007;negative regulation of immune system process#GO:0002683;regulation of lymphocyte proliferation#GO:0050670;regulation of cell adhesion#GO:0030155;negative regulation of cell adhesion#GO:0007162;negative regulation of T cell activation#GO:0050868;regulation of cell population proliferation#GO:0042127;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;negative regulation of multicellular organismal process#GO:0051241;negative regulation of leukocyte cell-cell adhesion#GO:1903038;regulation of cellular process#GO:0050794;regulation of cell-cell adhesion#GO:0022407;regulation of immune system process#GO:0002682;regulation of T cell proliferation#GO:0042129 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=30798|UniProtKB=Q9BZD7 Q9BZD7 PRRG3 PTHR24278:SF39 COAGULATION FACTOR TRANSMEMBRANE GAMMA-CARBOXYGLUTAMIC ACID PROTEIN 3 serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;serine-type peptidase activity#GO:0008236 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 serine protease#PC00203 HUMAN|HGNC=12841|UniProtKB=P07947 P07947 YES1 PTHR24418:SF90 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE YES signaling receptor binding#GO:0005102;binding#GO:0005488;non-membrane spanning protein tyrosine kinase activity#GO:0004715;protein binding#GO:0005515;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein tyrosine kinase activity#GO:0004713;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096 cell communication#GO:0007154;cellular developmental process#GO:0048869;enzyme-linked receptor protein signaling pathway#GO:0007167;developmental process#GO:0032502;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cell surface receptor signaling pathway#GO:0007166;signaling#GO:0023052;biological regulation#GO:0065007;cell differentiation#GO:0030154;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 non-receptor tyrosine protein kinase#PC00168 Cadherin signaling pathway#P00012>Yes#P00476;Parkinson disease#P00049>Src kinase#P01230;CCKR signaling map#P06959>YES1#P07142 HUMAN|HGNC=33858|UniProtKB=Q4G0N7 Q4G0N7 FAM229B PTHR35355:SF2 PROTEIN FAM229A PROTEIN FAM229B HUMAN|HGNC=8063|UniProtKB=O75694 O75694 NUP155 PTHR10350:SF6 NUCLEAR PORE COMPLEX PROTEIN NUP155 NUCLEAR PORE COMPLEX PROTEIN NUP155 structural molecule activity#GO:0005198;structural constituent of nuclear pore#GO:0017056 protein localization to membrane#GO:0072657;cellular component organization#GO:0016043;protein transport#GO:0015031;protein import into nucleus#GO:0006606;cellular localization#GO:0051641;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle organization#GO:0006996;intracellular protein transport#GO:0006886;cellular component organization or biogenesis#GO:0071840;establishment of RNA localization#GO:0051236;nucleobase-containing compound transport#GO:0015931;transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery#GO:0000972;protein localization to organelle#GO:0033365;RNA transport#GO:0050658;RNA localization#GO:0006403;localization within membrane#GO:0051668;nucleocytoplasmic transport#GO:0006913;nuclear transport#GO:0051169;nuclear export#GO:0051168;localization#GO:0051179;nucleic acid transport#GO:0050657;import into nucleus#GO:0051170;macromolecule localization#GO:0033036;nitrogen compound transport#GO:0071705;protein localization to nucleus#GO:0034504;transport#GO:0006810;RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;chromosome organization#GO:0051276;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234 intracellular organelle#GO:0043229;nuclear pore#GO:0005643;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;organelle#GO:0043226 transporter#PC00227 HUMAN|HGNC=1228|UniProtKB=P05155 P05155 SERPING1 PTHR11461:SF159 SERINE PROTEASE INHIBITOR, SERPIN PLASMA PROTEASE C1 INHIBITOR endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414;peptidase regulator activity#GO:0061134;enzyme regulator activity#GO:0030234;serine-type endopeptidase inhibitor activity#GO:0004867;molecular function inhibitor activity#GO:0140678;enzyme inhibitor activity#GO:0004857;endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease inhibitor#PC00191 HUMAN|HGNC=26193|UniProtKB=Q1MSJ5 Q1MSJ5 CSPP1 PTHR21616:SF2 CENTROSOME SPINDLE POLE ASSOCIATED PROTEIN CENTROSOME AND SPINDLE POLE-ASSOCIATED PROTEIN 1 regulation of cytokinesis#GO:0032465;regulation of cell division#GO:0051302;regulation of cellular process#GO:0050794;positive regulation of cell cycle#GO:0045787;biological regulation#GO:0065007;regulation of cell cycle process#GO:0010564;regulation of cell cycle#GO:0051726;positive regulation of biological process#GO:0048518;positive regulation of cell cycle process#GO:0090068;regulation of biological process#GO:0050789;positive regulation of cellular process#GO:0048522 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;spindle pole#GO:0000922;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;centrosome#GO:0005813;microtubule organizing center#GO:0005815;spindle#GO:0005819;intracellular organelle#GO:0043229 centromere DNA-binding protein#PC00071 HUMAN|HGNC=11982|UniProtKB=O60784 O60784 TOM1 PTHR13856:SF32 VHS DOMAIN CONTAINING PROTEIN FAMILY TARGET OF MYB1 MEMBRANE TRAFFICKING PROTEIN protein binding#GO:0005515;clathrin binding#GO:0030276;binding#GO:0005488 biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154 intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;vesicle#GO:0031982;membrane#GO:0016020;intracellular vesicle#GO:0097708 HUMAN|HGNC=12410|UniProtKB=Q9NY65 Q9NY65 TUBA8 PTHR11588:SF140 TUBULIN TUBULIN ALPHA-8 CHAIN nucleotide binding#GO:0000166;structural molecule activity#GO:0005198;ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;ribonucleotide binding#GO:0032553;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;structural constituent of cytoskeleton#GO:0005200;guanyl nucleotide binding#GO:0019001;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525 mitotic cell cycle#GO:0000278;cytoskeleton organization#GO:0007010;cell cycle#GO:0007049;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226;microtubule-based process#GO:0007017 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;supramolecular complex#GO:0099080;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081 cytoskeletal protein#PC00085;tubulin#PC00228 HUMAN|HGNC=12036|UniProtKB=Q9Y4K3 Q9Y4K3 TRAF6 PTHR10131:SF131 TNF RECEPTOR ASSOCIATED FACTOR TNF RECEPTOR-ASSOCIATED FACTOR 6 ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;signaling adaptor activity#GO:0035591;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;protein-macromolecule adaptor activity#GO:0030674;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;molecular adaptor activity#GO:0060090 cell surface receptor signaling pathway#GO:0007166;response to lipopolysaccharide#GO:0032496;cellular response to oxygen-containing compound#GO:1901701;defense response to symbiont#GO:0140546;signal transduction#GO:0007165;cellular process#GO:0009987;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;cellular response to lipopolysaccharide#GO:0071222;response to chemical#GO:0042221;defense response to other organism#GO:0098542;response to lipid#GO:0033993;cellular response to lipid#GO:0071396;response to oxygen-containing compound#GO:1901700;regulation of signaling#GO:0023051;cellular response to chemical stimulus#GO:0070887;immune system process#GO:0002376;regulation of intracellular signal transduction#GO:1902531;response to molecule of bacterial origin#GO:0002237;regulation of biological process#GO:0050789;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;regulation of response to stimulus#GO:0048583;response to external stimulus#GO:0009605;defense response#GO:0006952;innate immune response#GO:0045087;cellular response to molecule of bacterial origin#GO:0071219;immune response#GO:0006955;regulation of canonical NF-kappaB signal transduction#GO:0043122;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;response to other organism#GO:0051707;response to bacterium#GO:0009617;lipopolysaccharide-mediated signaling pathway#GO:0031663;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular response to biotic stimulus#GO:0071216;response to external biotic stimulus#GO:0043207;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794 plasma membrane#GO:0005886;synapse#GO:0045202;cellular anatomical structure#GO:0110165;glutamatergic synapse#GO:0098978;cell periphery#GO:0071944;membrane#GO:0016020;cytoplasmic side of plasma membrane#GO:0009898;side of membrane#GO:0098552;cell junction#GO:0030054;cytoplasmic side of membrane#GO:0098562 scaffold/adaptor protein#PC00226 Toll receptor signaling pathway#P00054>TRAF6#P01371;CCKR signaling map#P06959>TRAF6#P07111;p38 MAPK pathway#P05918>TRAF6#P06038 HUMAN|HGNC=5113|UniProtKB=P14652 P14652 HOXB2 PTHR45664:SF7 PROTEIN ZERKNUELLT 1-RELATED HOMEOBOX PROTEIN HOX-B2 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 homeodomain transcription factor#PC00119 HUMAN|HGNC=26780|UniProtKB=Q8N907 Q8N907 DAND5 PTHR15273:SF5 DAN DOMAIN FAMILY MEMBER 5 DAN DOMAIN FAMILY MEMBER 5 molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545 signaling#GO:0023052;circulatory system development#GO:0072359;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of cell communication#GO:0010648;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;animal gross anatomical part developmental process#GO:0160108;determination of bilateral symmetry#GO:0009855;negative regulation of signal transduction#GO:0009968;heart development#GO:0007507;signal transduction#GO:0007165;cellular process#GO:0009987;multicellular organism development#GO:0007275;anterior/posterior axis specification#GO:0009948;animal organ development#GO:0048513;left/right pattern formation#GO:0060972;anterior/posterior pattern specification#GO:0009952;regulation of cell communication#GO:0010646;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;determination of left/right symmetry#GO:0007368;cellular response to stimulus#GO:0051716;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092;system development#GO:0048731;cell communication#GO:0007154;anatomical structure development#GO:0048856;pattern specification process#GO:0007389;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;multicellular organismal process#GO:0032501;regionalization#GO:0003002;negative regulation of response to stimulus#GO:0048585;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;regulation of response to stimulus#GO:0048583;specification of symmetry#GO:0009799;negative regulation of cellular process#GO:0048523 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=3657|UniProtKB=P07332 P07332 FES PTHR24418:SF197 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE FES_FPS protein binding#GO:0005515;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;binding#GO:0005488;signaling receptor binding#GO:0005102;non-membrane spanning protein tyrosine kinase activity#GO:0004715;catalytic activity, acting on a protein#GO:0140096;protein tyrosine kinase activity#GO:0004713;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;signaling#GO:0023052;locomotion#GO:0040011;cell adhesion#GO:0007155;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;chemotaxis#GO:0006935;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;signal transduction#GO:0007165;cellular process#GO:0009987;taxis#GO:0042330;response to chemical#GO:0042221;biological regulation#GO:0065007;developmental process#GO:0032502;cell surface receptor signaling pathway#GO:0007166;cellular developmental process#GO:0048869;response to external stimulus#GO:0009605 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 non-receptor tyrosine protein kinase#PC00168 Axon guidance mediated by semaphorins#P00007>Fes#P00332 HUMAN|HGNC=17620|UniProtKB=Q9GZM8 Q9GZM8 NDEL1 PTHR10921:SF0 NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG 1 NUCLEAR DISTRIBUTION PROTEIN NUDE-LIKE 1 tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;microtubule binding#GO:0008017;protein binding#GO:0005515 regulation of neuron projection development#GO:0010975;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;establishment of mitotic spindle localization#GO:0040001;establishment of vesicle localization#GO:0051650;cytoskeleton organization#GO:0007010;chromosome localization#GO:0050000;organelle transport along microtubule#GO:0072384;cellular component assembly#GO:0022607;chromosome segregation#GO:0007059;microtubule organizing center organization#GO:0031023;establishment of spindle orientation#GO:0051294;microtubule-based process#GO:0007017;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;protein-containing complex assembly#GO:0065003;protein polymerization#GO:0051258;regulation of biological process#GO:0050789;centrosome cycle#GO:0007098;cell cycle process#GO:0022402;mitotic nuclear division#GO:0140014;microtubule nucleation#GO:0007020;cellular component organization#GO:0016043;centrosome localization#GO:0051642;regulation of cellular component organization#GO:0051128;establishment of organelle localization#GO:0051656;microtubule-based transport#GO:0099111;establishment or maintenance of cell polarity#GO:0007163;nuclear division#GO:0000280;cellular localization#GO:0051641;spindle localization#GO:0051653;establishment of spindle localization#GO:0051293;vesicle localization#GO:0051648;microtubule polymerization or depolymerization#GO:0031109;biological regulation#GO:0065007;cell migration#GO:0016477;cytoskeleton-dependent intracellular transport#GO:0030705;transport#GO:0006810;regulation of cell projection organization#GO:0031344;intracellular transport#GO:0046907;vesicle transport along microtubule#GO:0047496;mitotic cell cycle process#GO:1903047;vesicle cytoskeletal trafficking#GO:0099518;microtubule polymerization#GO:0046785;regulation of plasma membrane bounded cell projection organization#GO:0120035;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;establishment of mitotic spindle orientation#GO:0000132;establishment of cell polarity#GO:0030010;cell cycle#GO:0007049;microtubule cytoskeleton organization involved in mitosis#GO:1902850;mitotic cell cycle#GO:0000278;cell motility#GO:0048870;microtubule-based movement#GO:0007018;regulation of cellular process#GO:0050794;organelle localization#GO:0051640;supramolecular fiber organization#GO:0097435;localization#GO:0051179;organelle fission#GO:0048285;microtubule cytoskeleton organization#GO:0000226 condensed chromosome#GO:0000793;chromosome, centromeric region#GO:0000775;cytoskeleton#GO:0005856;centrosome#GO:0005813;microtubule organizing center#GO:0005815;membraneless organelle#GO:0043228;condensed chromosome, centromeric region#GO:0000779;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;supramolecular complex#GO:0099080;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687;kinetochore#GO:0000776;chromosome#GO:0005694;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=19225|UniProtKB=Q8WVX3 Q8WVX3 ARLN PTHR37367:SF1 CHROMOSOME 4 OPEN READING FRAME 3 SARCOPLASMIC_ENDOPLASMIC RETICULUM CALCIUM ATPASE REGULATOR ARLN HUMAN|HGNC=12950|UniProtKB=Q15637 Q15637 SF1 PTHR11208:SF45 RNA-BINDING PROTEIN RELATED SPLICING FACTOR 1 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729 RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;mRNA cis splicing, via spliceosome#GO:0045292;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 RNA processing factor#PC00147;RNA splicing factor#PC00148 HUMAN|HGNC=4019|UniProtKB=Q9BYC5 Q9BYC5 FUT8 PTHR13132:SF29 ALPHA- 1,6 -FUCOSYLTRANSFERASE ALPHA-(1,6)-FUCOSYLTRANSFERASE fucosyltransferase activity#GO:0008417;hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;catalytic activity#GO:0003824;glycosyltransferase activity#GO:0016757 biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487;glycoprotein biosynthetic process#GO:0009101;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100 glycosyltransferase#PC00111 Notch signaling pathway#P00045>Neurotic#P01115 HUMAN|HGNC=26907|UniProtKB=Q8NBW4 Q8NBW4 SLC38A9 PTHR22950:SF244 AMINO ACID TRANSPORTER NEUTRAL AMINO ACID TRANSPORTER 9 L-amino acid transmembrane transporter activity#GO:0015179;transporter activity#GO:0005215;carboxylic acid transmembrane transporter activity#GO:0046943;transmembrane transporter activity#GO:0022857;amino acid transmembrane transporter activity#GO:0015171 localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;amino acid transmembrane transport#GO:0003333;amino acid transport#GO:0006865;transport#GO:0006810;cellular process#GO:0009987 lytic vacuole#GO:0000323;vacuolar membrane#GO:0005774;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane#GO:0016020;lysosomal membrane#GO:0005765;vacuole#GO:0005773;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;lytic vacuole membrane#GO:0098852;lysosome#GO:0005764;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 secondary carrier transporter#PC00258;amino acid transporter#PC00046 HUMAN|HGNC=30948|UniProtKB=Q52M93 Q52M93 ZNF585B PTHR24376:SF228 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 585B gene-specific transcriptional regulator#PC00264;zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=11404|UniProtKB=O00506 O00506 STK25 PTHR48012:SF9 STERILE20-LIKE KINASE, ISOFORM B-RELATED SERINE_THREONINE-PROTEIN KINASE 25 phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=26988|UniProtKB=Q86XA0 Q86XA0 METTL23 PTHR14614:SF167 HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN HISTONE-ARGININE METHYLTRANSFERASE METTL23 catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein methyltransferase activity#GO:0008276;histone H3 methyltransferase activity#GO:0140938;histone modifying activity#GO:0140993;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;N-methyltransferase activity#GO:0008170;histone methyltransferase activity#GO:0042054 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;chromatin remodeling#GO:0006338;chromatin organization#GO:0006325;biological regulation#GO:0065007;epigenetic regulation of gene expression#GO:0040029;cellular component organization#GO:0016043;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;cellular process#GO:0009987;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 protein modifying enzyme#PC00260 HUMAN|HGNC=6773|UniProtKB=O15105 O15105 SMAD7 PTHR13703:SF44 SMAD SMAD FAMILY MEMBER 7 molecular function regulator activity#GO:0098772;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;molecular function inhibitor activity#GO:0140678;transcription regulatory region nucleic acid binding#GO:0001067;protein binding#GO:0005515 regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;regulation of RNA metabolic process#GO:0051252;intracellular signal transduction#GO:0035556;BMP signaling pathway#GO:0030509;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;response to growth factor#GO:0070848;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;response to BMP#GO:0071772;developmental process#GO:0032502;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;cellular response to growth factor stimulus#GO:0071363;response to endogenous stimulus#GO:0009719;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;signaling#GO:0023052;cell surface receptor signaling pathway#GO:0007166;cellular response to BMP stimulus#GO:0071773;cellular process#GO:0009987;signal transduction#GO:0007165;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;intracellular signaling cassette#GO:0141124 nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;nuclear protein-containing complex#GO:0140513 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 TGF-beta signaling pathway#P00052>I-Smads#P01289;TGF-beta signaling pathway#P00052>I-SMAD#G01548 HUMAN|HGNC=10913|UniProtKB=Q9UP95 Q9UP95 SLC12A4 PTHR11827:SF46 SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS SOLUTE CARRIER FAMILY 12 MEMBER 4 solute:monoatomic cation symporter activity#GO:0015294;monoatomic ion transmembrane transporter activity#GO:0015075;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873;chloride transmembrane transporter activity#GO:0015108;secondary active transmembrane transporter activity#GO:0015291;monoatomic anion transmembrane transporter activity#GO:0008509;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;potassium ion transmembrane transporter activity#GO:0015079;monoatomic cation transmembrane transporter activity#GO:0008324;symporter activity#GO:0015293 transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698;chloride transport#GO:0006821;transport#GO:0006810;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;potassium ion transmembrane transport#GO:0071805;monoatomic anion transport#GO:0006820;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;cell periphery#GO:0071944;apical part of cell#GO:0045177;membrane#GO:0016020;apical plasma membrane#GO:0016324 secondary carrier transporter#PC00258 HUMAN|HGNC=24595|UniProtKB=Q8TCX1 Q8TCX1 DYNC2LI1 PTHR13236:SF0 DYNEIN 2 LIGHT INTERMEDIATE CHAIN, ISOFORM 2 CYTOPLASMIC DYNEIN 2 LIGHT INTERMEDIATE CHAIN 1 protein binding#GO:0005515;binding#GO:0005488 cellular component assembly#GO:0022607;cytoskeleton-dependent intracellular transport#GO:0030705;plasma membrane bounded cell projection organization#GO:0120036;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;intraciliary transport involved in cilium assembly#GO:0035735;cell projection assembly#GO:0030031;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;transport along microtubule#GO:0010970;establishment of localization#GO:0051234;microtubule-based process#GO:0007017;plasma membrane bounded cell projection assembly#GO:0120031;intracellular transport#GO:0046907;transport#GO:0006810;cell projection organization#GO:0030030;microtubule-based movement#GO:0007018;intraciliary retrograde transport#GO:0035721;intraciliary transport#GO:0042073;cilium assembly#GO:0060271;cellular component organization#GO:0016043;localization#GO:0051179;cellular localization#GO:0051641;cilium organization#GO:0044782;organelle assembly#GO:0070925;microtubule-based transport#GO:0099111 microtubule organizing center#GO:0005815;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;cytoplasmic dynein complex#GO:0005868;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;ciliary plasm#GO:0097014;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;cilium#GO:0005929;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;axoneme#GO:0005930;dynein complex#GO:0030286;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165 microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=17057|UniProtKB=Q9Y2G2 Q9Y2G2 CARD8 PTHR46985:SF4 NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 8 signaling receptor activity#GO:0038023;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047;peptidase activator activity#GO:0016504;pattern recognition receptor activity#GO:0038187;enzyme regulator activity#GO:0030234;molecular transducer activity#GO:0060089;molecular function activator activity#GO:0140677;endopeptidase regulator activity#GO:0061135;peptidase regulator activity#GO:0061134 regulation of response to external stimulus#GO:0032101;response to stress#GO:0006950;positive regulation of immune system process#GO:0002684;cellular process#GO:0009987;activation of immune response#GO:0002253;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;positive regulation of response to external stimulus#GO:0032103;response to stimulus#GO:0050896;signaling#GO:0023052;apoptotic process#GO:0006915;regulation of biological process#GO:0050789;intrinsic apoptotic signaling pathway#GO:0097193;immune system process#GO:0002376;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;activation of innate immune response#GO:0002218;positive regulation of innate immune response#GO:0045089;apoptotic signaling pathway#GO:0097190;regulation of innate immune response#GO:0045088;defense response#GO:0006952;positive regulation of response to biotic stimulus#GO:0002833;regulation of response to stress#GO:0080134;regulation of response to stimulus#GO:0048583;positive regulation of defense response#GO:0031349;positive regulation of immune response#GO:0050778;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of response to biotic stimulus#GO:0002831;programmed cell death#GO:0012501;cellular response to stimulus#GO:0051716;cell death#GO:0008219;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of defense response#GO:0031347;inflammatory response#GO:0006954;regulation of immune response#GO:0050776 intracellular organelle#GO:0043229;canonical inflammasome complex#GO:0061702;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 defense/immunity protein#PC00090 HUMAN|HGNC=14599|UniProtKB=Q9UJW2 Q9UJW2 TINAG PTHR12411:SF274 CYSTEINE PROTEASE FAMILY C1-RELATED TUBULOINTERSTITIAL NEPHRITIS ANTIGEN cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;cysteine-type endopeptidase activity#GO:0004197;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;protein catabolic process#GO:0030163;catabolic process#GO:0009056;primary metabolic process#GO:0044238;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;vacuole#GO:0005773;extracellular region#GO:0005576;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 protein modifying enzyme#PC00260;cysteine protease#PC00081;protease#PC00190 HUMAN|HGNC=21208|UniProtKB=Q9H7D7 Q9H7D7 WDR26 PTHR22838:SF28 WD REPEAT PROTEIN 26-RELATED WD REPEAT-CONTAINING PROTEIN 26 modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 transferase complex#GO:1990234;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;intracellular protein-containing complex#GO:0140535 HUMAN|HGNC=4927|UniProtKB=Q92504 Q92504 SLC39A7 PTHR16950:SF25 ZINC TRANSPORTER SLC39A7 HISTIDINE-RICH MEMBRANE PROTEIN KE4 ZINC TRANSPORTER SLC39A7 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;zinc ion transmembrane transporter activity#GO:0005385;transition metal ion transmembrane transporter activity#GO:0046915;monoatomic cation transmembrane transporter activity#GO:0008324;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075 monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;zinc ion transport#GO:0006829;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;transport#GO:0006810;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;establishment of localization#GO:0051234;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;intracellular monoatomic ion homeostasis#GO:0006873;metal ion transport#GO:0030001;homeostatic process#GO:0042592;transition metal ion transport#GO:0000041;inorganic ion homeostasis#GO:0098771;zinc ion transmembrane transport#GO:0071577;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811 membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227 primary active transporter#PC00068;transporter#PC00227 HUMAN|HGNC=26238|UniProtKB=Q8WVC6 Q8WVC6 DCAKD PTHR10695:SF46 DEPHOSPHO-COA KINASE-RELATED DEPHOSPHO-COA KINASE DOMAIN-CONTAINING PROTEIN transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773 nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;organophosphate metabolic process#GO:0019637;sulfur compound metabolic process#GO:0006790;cellular process#GO:0009987;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;purine-containing compound metabolic process#GO:0072521;organophosphate biosynthetic process#GO:0090407;purine-containing compound biosynthetic process#GO:0072522 metabolite interconversion enzyme#PC00262;kinase#PC00137 Coenzyme A biosynthesis#P02736>Pantetheine-phosphate adenyltransferase#P02886;Coenzyme A biosynthesis#P02736>Dephospho-CoA kinase#P02884 HUMAN|HGNC=2654|UniProtKB=O00622 O00622 CCN1 PTHR11348:SF18 CONNECTIVE TISSUE GROWTH FACTOR-RELATED CCN FAMILY MEMBER 1 protein binding#GO:0005515;protein-containing complex binding#GO:0044877;signaling receptor binding#GO:0005102;binding#GO:0005488;glycosaminoglycan binding#GO:0005539;integrin binding#GO:0005178;carbohydrate derivative binding#GO:0097367;cell adhesion molecule binding#GO:0050839;heparin binding#GO:0008201 signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of cell migration#GO:0030335;cellular process#GO:0009987;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;positive regulation of developmental process#GO:0051094;regulation of cell migration#GO:0030334;regulation of cell differentiation#GO:0045595;positive regulation of cell differentiation#GO:0045597;positive regulation of locomotion#GO:0040017;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;positive regulation of cell motility#GO:2000147;regulation of developmental process#GO:0050793;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell adhesion#GO:0007155;cell communication#GO:0007154;regulation of cell motility#GO:2000145 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 growth factor#PC00112;intercellular signal molecule#PC00207 HUMAN|HGNC=1253|UniProtKB=P58499 P58499 FAM3B PTHR14592:SF2 UNCHARACTERIZED FAM3 PROTEIN FAM3B receptor ligand activity#GO:0048018;cytokine activity#GO:0005125;signaling receptor regulator activity#GO:0030545;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090;antimicrobial response protein#PC00051 HUMAN|HGNC=1962|UniProtKB=P17787 P17787 CHRNB2 PTHR18945:SF901 NEUROTRANSMITTER GATED ION CHANNEL NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;ligand-gated monoatomic cation channel activity#GO:0099094;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;channel activity#GO:0015267;molecular transducer activity#GO:0060089;ligand-gated monoatomic ion channel activity#GO:0015276;signaling receptor activity#GO:0038023;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;transporter activity#GO:0005215;neurotransmitter receptor activity#GO:0030594;monoatomic cation transmembrane transporter activity#GO:0008324;gated channel activity#GO:0022836;postsynaptic neurotransmitter receptor activity#GO:0098960 calcium ion transport#GO:0006816;regulation of membrane potential#GO:0042391;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;synaptic signaling#GO:0099536;response to chemical#GO:0042221;response to oxygen-containing compound#GO:1901700;cellular response to chemical stimulus#GO:0070887;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;transmembrane transport#GO:0055085;regulation of biological process#GO:0050789;signaling#GO:0023052;response to stimulus#GO:0050896;transport#GO:0006810;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;cellular response to nitrogen compound#GO:1901699;acetylcholine receptor signaling pathway#GO:0095500;synaptic transmission, cholinergic#GO:0007271;trans-synaptic signaling#GO:0099537;response to nitrogen compound#GO:1901698;cell communication#GO:0007154;localization#GO:0051179;monoatomic cation transport#GO:0006812;cellular response to stimulus#GO:0051716;chemical synaptic transmission#GO:0007268;membrane depolarization#GO:0051899;metal ion transport#GO:0030001;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916 transmembrane transporter complex#GO:1902495;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;plasma membrane protein complex#GO:0098797;postsynapse#GO:0098794;membrane protein complex#GO:0098796;transporter complex#GO:1990351;cell junction#GO:0030054;signaling receptor complex#GO:0043235;synaptic membrane#GO:0097060;plasma membrane#GO:0005886;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;plasma membrane region#GO:0098590;postsynaptic specialization#GO:0099572;cell periphery#GO:0071944;membrane#GO:0016020 ligand-gated ion channel#PC00141 Nicotine pharmacodynamics pathway#P06587>CHRNB2#P06613;Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086;Nicotinic acetylcholine receptor signaling pathway#P00044>beta#P01095 HUMAN|HGNC=11057|UniProtKB=P30825 P30825 SLC7A1 PTHR43243:SF28 INNER MEMBRANE TRANSPORTER YGJI-RELATED HIGH AFFINITY CATIONIC AMINO ACID TRANSPORTER 1 amino acid transmembrane transporter activity#GO:0015171;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810;amino acid transport#GO:0006865 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 secondary carrier transporter#PC00258;amino acid transporter#PC00046 HUMAN|HGNC=2571|UniProtKB=P49447 P49447 CYB561 PTHR10106:SF14 CYTOCHROME B561-RELATED TRANSMEMBRANE ASCORBATE-DEPENDENT REDUCTASE CYB561 oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 intracellular iron ion homeostasis#GO:0006879;homeostatic process#GO:0042592;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion homeostasis#GO:0050801;carbohydrate homeostasis#GO:0033500;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;inorganic ion homeostasis#GO:0098771;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;vesicle#GO:0031982;intracellular vesicle#GO:0097708;secretory granule membrane#GO:0030667;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;secretory vesicle#GO:0099503;membrane#GO:0016020;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505 reductase#PC00198;oxidoreductase#PC00176 HUMAN|HGNC=38709|UniProtKB=A8MT65 A8MT65 ZNF891 PTHR24381:SF76 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 891 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=13582|UniProtKB=Q9UK99 Q9UK99 FBXO3 PTHR46550:SF7 F-BOX ONLY PROTEIN 3 F-BOX ONLY PROTEIN 3 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=758|UniProtKB=P00966 P00966 ASS1 PTHR11587:SF5 ARGININOSUCCINATE SYNTHASE ARGININOSUCCINATE SYNTHASE catalytic activity#GO:0003824;ligase activity#GO:0016874;ligase activity, forming carbon-nitrogen bonds#GO:0016879 amino acid biosynthetic process#GO:0008652;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;small molecule biosynthetic process#GO:0044283;proteinogenic amino acid biosynthetic process#GO:0170038;L-arginine biosynthetic process#GO:0006526;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;cellular process#GO:0009987;carboxylic acid biosynthetic process#GO:0046394;proteinogenic amino acid metabolic process#GO:0170039;small molecule metabolic process#GO:0044281;arginine metabolic process#GO:0006525;amino acid metabolic process#GO:0006520;biosynthetic process#GO:0009058 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 metabolite interconversion enzyme#PC00262;ligase#PC00142 Arginine biosynthesis#P02728>Argininosuccinate synthase#P02840 HUMAN|HGNC=17704|UniProtKB=Q9UPQ7 Q9UPQ7 PDZRN3 PTHR15545:SF5 PDZ DOMAIN CONTAINING RING FINGER PROTEIN 3, 4 E3 UBIQUITIN-PROTEIN LIGASE PDZRN3 ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 cellular process#GO:0009987;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;neuromuscular junction development#GO:0007528;cellular component organization#GO:0016043;protein modification process#GO:0036211;primary metabolic process#GO:0044238;protein modification by small protein conjugation#GO:0032446;cell junction organization#GO:0034330;protein modification by small protein conjugation or removal#GO:0070647;synapse organization#GO:0050808;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412 neuromuscular junction#GO:0031594;cellular anatomical structure#GO:0110165;synapse#GO:0045202;cell junction#GO:0030054 HUMAN|HGNC=19885|UniProtKB=Q96ED9 Q96ED9 HOOK2 PTHR18947:SF37 HOOK PROTEINS PROTEIN HOOK HOMOLOG 2 tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;microtubule binding#GO:0008017;protein binding#GO:0005515 cytoskeleton organization#GO:0007010;cytoskeleton-dependent intracellular transport#GO:0030705;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle organization#GO:0006996;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;transport#GO:0006810;intracellular transport#GO:0046907;cytoplasmic microtubule organization#GO:0031122;cellular component organization#GO:0016043;supramolecular fiber organization#GO:0097435;localization#GO:0051179;microtubule cytoskeleton organization#GO:0000226;cellular localization#GO:0051641 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;centrosome#GO:0005813;microtubule organizing center#GO:0005815;intracellular organelle#GO:0043229 membrane traffic protein#PC00150 HUMAN|HGNC=18210|UniProtKB=Q96PD6 Q96PD6 MOGAT1 PTHR12317:SF26 DIACYLGLYCEROL O-ACYLTRANSFERASE 2-ACYLGLYCEROL O-ACYLTRANSFERASE 1 acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746 cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;glycerolipid metabolic process#GO:0046486;triglyceride biosynthetic process#GO:0019432;lipid metabolic process#GO:0006629;triglyceride metabolic process#GO:0006641;acylglycerol metabolic process#GO:0006639;metabolic process#GO:0008152;neutral lipid metabolic process#GO:0006638 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 acyltransferase#PC00042;transferase#PC00220 HUMAN|HGNC=13575|UniProtKB=O60885 O60885 BRD4 PTHR22880:SF143 FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS BROMODOMAIN-CONTAINING PROTEIN 4 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;histone reader activity#GO:0140566;chromatin-protein adaptor activity#GO:0140463 cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;chromatin remodeling#GO:0006338;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468 chromosome#GO:0005694;chromatin#GO:0000785;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=1836|UniProtKB=Q15744 Q15744 CEBPE PTHR23334:SF27 CCAAT/ENHANCER BINDING PROTEIN CCAAT_ENHANCER-BINDING PROTEIN EPSILON RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;myeloid cell differentiation#GO:0030099;regulation of cellular process#GO:0050794;cell development#GO:0048468;regulation of biological process#GO:0050789;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;developmental process#GO:0032502;regulation of nucleobase-containing compound metabolic process#GO:0019219;hemopoiesis#GO:0030097;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 basic leucine zipper transcription factor#PC00056;DNA-binding transcription factor#PC00218 HUMAN|HGNC=18470|UniProtKB=Q9NYG2 Q9NYG2 ZDHHC3 PTHR22883:SF246 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE ZDHHC3 catalytic activity, acting on a protein#GO:0140096;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;palmitoyltransferase activity#GO:0016409;acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824 regulation of response to stimulus#GO:0048583;regulation of G protein-coupled receptor signaling pathway#GO:0008277;protein localization to cell periphery#GO:1990778;protein targeting to membrane#GO:0006612;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;cellular process#GO:0009987;establishment of protein localization#GO:0045184;macromolecule localization#GO:0033036;establishment of protein localization to membrane#GO:0090150;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of signaling#GO:0023051;localization within membrane#GO:0051668;cellular localization#GO:0051641;localization#GO:0051179;regulation of biological process#GO:0050789;protein localization to plasma membrane#GO:0072659;protein localization to membrane#GO:0072657;regulation of cell communication#GO:0010646;protein targeting#GO:0006605;regulation of cellular process#GO:0050794 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 protein modifying enzyme#PC00260 HUMAN|HGNC=12304|UniProtKB=Q15642 Q15642 TRIP10 PTHR15735:SF17 FCH AND DOUBLE SH3 DOMAINS PROTEIN CDC42-INTERACTING PROTEIN 4 cellular component organization#GO:0016043;regulation of biological process#GO:0050789;cellular process#GO:0009987;regulation of organelle organization#GO:0033043;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;membrane organization#GO:0061024;endomembrane system organization#GO:0010256;regulation of actin cytoskeleton organization#GO:0032956;regulation of actin filament-based process#GO:0032970;plasma membrane organization#GO:0007009;cellular component organization or biogenesis#GO:0071840 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 non-motor actin binding protein#PC00165;cytoskeletal protein#PC00085 HUMAN|HGNC=48369|UniProtKB=B4DZS4 B4DZS4 TCP11X1 PTHR12832:SF21 TESTIS-SPECIFIC PROTEIN PBS13 T-COMPLEX 11 T-COMPLEX PROTEIN 11-LIKE X-LINKED PROTEIN 1-RELATED regulation of developmental process#GO:0050793;biological regulation#GO:0065007;signaling#GO:0023052;regulation of multicellular organismal process#GO:0051239;response to stimulus#GO:0050896;regulation of reproductive process#GO:2000241;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cell development#GO:0060284;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;regulation of cell differentiation#GO:0045595 cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;9+2 motile cilium#GO:0097729;intracellular organelle#GO:0043229;cilium#GO:0005929;acrosomal vesicle#GO:0001669;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;motile cilium#GO:0031514;vesicle#GO:0031982;intracellular vesicle#GO:0097708;cytoplasm#GO:0005737;sperm flagellum#GO:0036126;endomembrane system#GO:0012505;secretory vesicle#GO:0099503 microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=25455|UniProtKB=Q969E8 Q969E8 TSR2 PTHR21250:SF0 PRE-RRNA-PROCESSING PROTEIN TSR2 HOMOLOG PRE-RRNA-PROCESSING PROTEIN TSR2 HOMOLOG cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;maturation of LSU-rRNA#GO:0000470;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;maturation of SSU-rRNA#GO:0030490;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;ribosomal small subunit biogenesis#GO:0042274;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;ribonucleoprotein complex biogenesis#GO:0022613;ribosomal large subunit biogenesis#GO:0042273;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=92|UniProtKB=P49748 P49748 ACADVL PTHR43884:SF11 ACYL-COA DEHYDROGENASE VERY LONG-CHAIN ACYL-COA DEHYDROGENASE, MITOCHONDRIAL nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167;binding#GO:0005488;anion binding#GO:0043168;small molecule binding#GO:0036094;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;lipid binding#GO:0008289;catalytic activity#GO:0003824;heterocyclic compound binding#GO:1901363;oxidoreductase activity#GO:0016491 cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;lipid catabolic process#GO:0016042;monocarboxylic acid catabolic process#GO:0072329;lipid metabolic process#GO:0006629;fatty acid beta-oxidation#GO:0006635;fatty acid oxidation#GO:0019395;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;lipid modification#GO:0030258;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;small molecule catabolic process#GO:0044282;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;oxoacid metabolic process#GO:0043436;fatty acid catabolic process#GO:0009062;lipid oxidation#GO:0034440 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;membrane#GO:0016020;organelle envelope#GO:0031967;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 dehydrogenase#PC00092;oxidoreductase#PC00176 HUMAN|HGNC=10729|UniProtKB=Q9H3S1 Q9H3S1 SEMA4A PTHR11036:SF15 SEMAPHORIN SEMAPHORIN-4A receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;binding#GO:0005488;signaling receptor binding#GO:0005102;molecular function activator activity#GO:0140677;protein binding#GO:0005515 cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;neuron projection development#GO:0031175;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;response to chemical#GO:0042221;taxis#GO:0042330;cell surface receptor signaling pathway#GO:0007166;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;cell projection morphogenesis#GO:0048858;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;positive regulation of cell motility#GO:2000147;cell development#GO:0048468;signaling#GO:0023052;cell morphogenesis#GO:0000902;cell differentiation#GO:0030154;response to stimulus#GO:0050896;cell projection organization#GO:0030030;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;neuron development#GO:0048666;axonogenesis#GO:0007409;positive regulation of cell migration#GO:0030335;positive regulation of cellular process#GO:0048522;axon guidance#GO:0007411;axon development#GO:0061564;regulation of locomotion#GO:0040012;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;regulation of cell migration#GO:0030334;neurogenesis#GO:0022008;positive regulation of locomotion#GO:0040017;response to external stimulus#GO:0009605;neuron projection guidance#GO:0097485;cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;locomotion#GO:0040011;regulation of cellular process#GO:0050794;chemotaxis#GO:0006935;system development#GO:0048731;anatomical structure development#GO:0048856;cell communication#GO:0007154;regulation of cell motility#GO:2000145 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 membrane-bound signaling molecule#PC00152 HUMAN|HGNC=19182|UniProtKB=O94885 O94885 SASH1 PTHR12301:SF3 SAM-DOMAIN, SH3 AND NUCLEAR LOCALIZATION SIGNALS PROTEIN RELATED SAM AND SH3 DOMAIN-CONTAINING PROTEIN 1 enzyme binding#GO:0019899;protein kinase binding#GO:0019901;kinase binding#GO:0019900;binding#GO:0005488;protein binding#GO:0005515 positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of non-canonical NF-kappaB signal transduction#GO:1901224;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of response to stimulus#GO:0048584;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;regulation of biological process#GO:0050789;regulation of non-canonical NF-kappaB signal transduction#GO:1901222;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;positive regulation of signaling#GO:0023056 HUMAN|HGNC=3976|UniProtKB=P02794 P02794 FTH1 PTHR11431:SF37 FERRITIN FERRITIN HEAVY CHAIN metal ion binding#GO:0046872;cation binding#GO:0043169;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;transition metal ion binding#GO:0046914;iron ion binding#GO:0005506;ferrous iron binding#GO:0008198 metal ion transport#GO:0030001;monoatomic cation transport#GO:0006812;localization#GO:0051179;establishment of localization#GO:0051234;monoatomic ion transport#GO:0006811;iron ion transport#GO:0006826;transition metal ion transport#GO:0000041;transport#GO:0006810 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 storage protein#PC00210 HUMAN|HGNC=37279|UniProtKB=B2RXF0 B2RXF0 TMEM229A PTHR31746:SF2 TRANSMEMBRANE PROTEIN 229 FAMILY MEMBER TRANSMEMBRANE PROTEIN 229A HUMAN|HGNC=27289|UniProtKB=A4GXA9 A4GXA9 EME2 PTHR21077:SF6 EME1 PROTEIN STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT EME2 reciprocal meiotic recombination#GO:0007131;cellular response to stress#GO:0033554;nuclear division#GO:0000280;negative regulation of mitotic cell cycle#GO:0045930;DNA-templated DNA replication#GO:0006261;mitotic intra-S DNA damage checkpoint signaling#GO:0031573;cell cycle process#GO:0022402;regulation of biological process#GO:0050789;signal transduction in response to DNA damage#GO:0042770;meiosis I#GO:0007127;meiotic cell cycle process#GO:1903046;negative regulation of cell cycle phase transition#GO:1901988;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;regulation of cell cycle#GO:0051726;signaling#GO:0023052;response to stimulus#GO:0050896;DNA recombination#GO:0006310;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;meiotic cell cycle#GO:0051321;double-strand break repair#GO:0006302;cellular component organization or biogenesis#GO:0071840;negative regulation of cell cycle#GO:0045786;cellular process#GO:0009987;signal transduction#GO:0007165;response to stress#GO:0006950;organelle organization#GO:0006996;regulation of cell cycle process#GO:0010564;cell cycle checkpoint signaling#GO:0000075;sexual reproduction#GO:0019953;meiosis I cell cycle process#GO:0061982;intracellular signal transduction#GO:0035556;organelle fission#GO:0048285;cell communication#GO:0007154;mitotic DNA damage checkpoint signaling#GO:0044773;DNA replication#GO:0006260;cellular response to stimulus#GO:0051716;reciprocal homologous recombination#GO:0140527;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mitotic cell cycle checkpoint signaling#GO:0007093;cell cycle#GO:0007049;regulation of cell cycle phase transition#GO:1901987;reproductive process#GO:0022414;homologous recombination#GO:0035825;regulation of cellular process#GO:0050794;mitotic cell cycle#GO:0000278;negative regulation of cell cycle process#GO:0010948;DNA damage response#GO:0006974;negative regulation of cellular process#GO:0048523;DNA repair#GO:0006281;mitotic cell cycle process#GO:1903047;meiotic nuclear division#GO:0140013;macromolecule metabolic process#GO:0043170;mitotic DNA integrity checkpoint signaling#GO:0044774;regulation of mitotic cell cycle#GO:0007346;resolution of meiotic recombination intermediates#GO:0000712;DNA integrity checkpoint signaling#GO:0031570;replication fork processing#GO:0031297;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;DNA damage checkpoint signaling#GO:0000077 intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;endonuclease complex#GO:1905348 HUMAN|HGNC=23162|UniProtKB=Q5BKT4 Q5BKT4 ALG10 PTHR12989:SF11 ALPHA-1,2-GLUCOSYLTRANSFERASE ALG10 DOL-P-GLC:GLC(2)MAN(9)GLCNAC(2)-PP-DOL ALPHA-1,2-GLUCOSYLTRANSFERASE A catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758;glycosyltransferase activity#GO:0016757;glucosyltransferase activity#GO:0046527 biosynthetic process#GO:0009058;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;glycoprotein biosynthetic process#GO:0009101;protein N-linked glycosylation#GO:0006487;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 transferase#PC00220 HUMAN|HGNC=4286|UniProtKB=Q9NTQ9 Q9NTQ9 GJB4 PTHR11984:SF30 CONNEXIN GAP JUNCTION BETA-4 PROTEIN passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;wide pore channel activity#GO:0022829;channel activity#GO:0015267 signaling#GO:0023052;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789 membrane protein complex#GO:0098796;cell-cell junction#GO:0005911;membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;cell junction#GO:0030054;anchoring junction#GO:0070161 gap junction#PC00105;cell junction protein#PC00070 HUMAN|HGNC=9858|UniProtKB=P47736 P47736 RAP1GAP PTHR15711:SF3 RAP GTPASE-ACTIVATING PROTEIN RAP1 GTPASE-ACTIVATING PROTEIN 1 enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047 regulation of biological process#GO:0050789;biological regulation#GO:0065007;regulation of cell-cell adhesion#GO:0022407;regulation of cellular process#GO:0050794;regulation of cell adhesion#GO:0030155 cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane#GO:0005886;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;axon#GO:0030424 G-protein modulator#PC00022;GTPase-activating protein#PC00257 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Rap1GAP#P00737 HUMAN|HGNC=2315|UniProtKB=Q96FN4 Q96FN4 CPNE2 PTHR10857:SF3 COPINE COPINE-2 lipid binding#GO:0008289;phospholipid binding#GO:0005543;binding#GO:0005488 response to chemical#GO:0042221;response to calcium ion#GO:0051592;response to stimulus#GO:0050896;cellular response to chemical stimulus#GO:0070887;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to metal ion#GO:0010038 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 calcium-binding protein#PC00060 HUMAN|HGNC=34401|UniProtKB=A2RU48 A2RU48 SMCO3 PTHR35972:SF1 SINGLE-PASS MEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 3 SINGLE-PASS MEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 3 HUMAN|HGNC=25410|UniProtKB=P0C0E4 P0C0E4 RAB40AL PTHR47980:SF106 LD44762P RAS-RELATED PROTEIN RAB-40A-LIKE ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 macromolecule metabolic process#GO:0043170;establishment of localization#GO:0051234;exocytosis#GO:0006887;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;transport#GO:0006810;vesicle-mediated transport#GO:0016192;proteasomal protein catabolic process#GO:0010498;cellular process#GO:0009987;localization#GO:0051179;protein metabolic process#GO:0019538;secretion#GO:0046903;secretion by cell#GO:0032940;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;catabolic process#GO:0009056;export from cell#GO:0140352;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;plasma membrane#GO:0005886;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cell periphery#GO:0071944;vesicle#GO:0031982;membrane#GO:0016020;intracellular vesicle#GO:0097708;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;intracellular organelle#GO:0043229 HUMAN|HGNC=15586|UniProtKB=Q9HBW1 Q9HBW1 LRRC4 PTHR24369:SF9 ANTIGEN BSP, PUTATIVE-RELATED LEUCINE-RICH REPEAT-CONTAINING PROTEIN 4 protein binding#GO:0005515;cell-cell adhesion mediator activity#GO:0098632;binding#GO:0005488;cell adhesion molecule binding#GO:0050839;cell adhesion mediator activity#GO:0098631 cellular localization#GO:0051641;synaptic membrane adhesion#GO:0099560;animal gross anatomical part developmental process#GO:0160108;regulation of signaling#GO:0023051;postsynaptic density organization#GO:0097106;cell adhesion#GO:0007155;synapse assembly#GO:0007416;excitatory synapse assembly#GO:1904861;cellular component organization#GO:0016043;cell junction assembly#GO:0034329;protein localization to membrane#GO:0072657;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;regulation of trans-synaptic signaling#GO:0099177;cellular component assembly#GO:0022607;nervous system development#GO:0007399;cell-cell adhesion#GO:0098609;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;anatomical structure development#GO:0048856;localization#GO:0051179;system development#GO:0048731;postsynaptic specialization organization#GO:0099084;localization within membrane#GO:0051668;synapse organization#GO:0050808;cell junction organization#GO:0034330;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;postsynapse organization#GO:0099173;modulation of chemical synaptic transmission#GO:0050804;intracellular protein localization#GO:0008104;developmental process#GO:0032502;multicellular organismal process#GO:0032501;membrane organization#GO:0061024;biological regulation#GO:0065007;macromolecule localization#GO:0033036 membrane#GO:0016020;cell periphery#GO:0071944;neuron to neuron synapse#GO:0098984;glutamatergic synapse#GO:0098978;plasma membrane region#GO:0098590;postsynaptic specialization#GO:0099572;plasma membrane#GO:0005886;synaptic membrane#GO:0097060;cell junction#GO:0030054;postsynapse#GO:0098794;cellular anatomical structure#GO:0110165;synapse#GO:0045202;asymmetric synapse#GO:0032279;organelle#GO:0043226;postsynaptic specialization membrane#GO:0099634;postsynaptic membrane#GO:0045211;postsynaptic density#GO:0014069;postsynaptic density membrane#GO:0098839 cell adhesion molecule#PC00069 HUMAN|HGNC=1765|UniProtKB=P55285 P55285 CDH6 PTHR24027:SF322 CADHERIN-23 CADHERIN-6 protein binding#GO:0005515;beta-catenin binding#GO:0008013;binding#GO:0005488;cell adhesion molecule binding#GO:0050839 anatomical structure development#GO:0048856;synaptic membrane adhesion#GO:0099560;synapse organization#GO:0050808;cell adhesion#GO:0007155;cell morphogenesis#GO:0000902;cell junction organization#GO:0034330;cell motility#GO:0048870;adherens junction organization#GO:0034332;cell junction assembly#GO:0034329;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cellular component organization or biogenesis#GO:0071840;developmental process#GO:0032502;cell-cell junction organization#GO:0045216;cell-cell junction assembly#GO:0007043;cellular component assembly#GO:0022607;cell migration#GO:0016477;cellular component biogenesis#GO:0044085;cell-cell adhesion#GO:0098609;cellular process#GO:0009987 anchoring junction#GO:0070161;adherens junction#GO:0005912;extrinsic component of plasma membrane#GO:0019897;cell junction#GO:0030054;extrinsic component of membrane#GO:0019898;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane#GO:0016020;cell-cell junction#GO:0005911;membrane protein complex#GO:0098796 cadherin#PC00057;cell adhesion molecule#PC00069 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HUMAN|HGNC=11249|UniProtKB=P16150 P16150 SPN PTHR35265:SF1 LEUKOSIALIN LEUKOSIALIN HUMAN|HGNC=20819|UniProtKB=Q86XQ3 Q86XQ3 CATSPER3 PTHR47131:SF1 CATION CHANNEL SPERM-ASSOCIATED PROTEIN 3 CATION CHANNEL SPERM-ASSOCIATED PROTEIN 3 passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;monoatomic cation channel activity#GO:0005261;voltage-gated calcium channel activity#GO:0005245;channel activity#GO:0015267;transporter activity#GO:0005215;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;voltage-gated channel activity#GO:0022832;calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324 reproductive process#GO:0022414;metal ion transport#GO:0030001;cell motility#GO:0048870;microtubule-based movement#GO:0007018;germ cell development#GO:0007281;anatomical structure maturation#GO:0071695;developmental process involved in reproduction#GO:0003006;multicellular organismal reproductive process#GO:0048609;anatomical structure development#GO:0048856;localization#GO:0051179;monoatomic cation transport#GO:0006812;spermatid development#GO:0007286;sexual reproduction#GO:0019953;male gamete generation#GO:0048232;developmental maturation#GO:0021700;cellular developmental process#GO:0048869;establishment of localization#GO:0051234;cell maturation#GO:0048469;transport#GO:0006810;spermatogenesis#GO:0007283;developmental process#GO:0032502;flagellated sperm motility#GO:0030317;cell development#GO:0048468;cellular process involved in reproduction in multicellular organism#GO:0022412;gamete generation#GO:0007276;cell differentiation#GO:0030154;sodium ion transport#GO:0006814;sperm motility#GO:0097722;monoatomic ion transport#GO:0006811;cilium-dependent cell motility#GO:0060285;cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;spermatid differentiation#GO:0048515;sperm capacitation#GO:0048240;cellular process#GO:0009987;cilium movement involved in cell motility#GO:0060294;microtubule-based process#GO:0007017 cation channel complex#GO:0034703;transporter complex#GO:1990351;cell periphery#GO:0071944;secretory vesicle#GO:0099503;membrane#GO:0016020;cytoplasm#GO:0005737;plasma membrane#GO:0005886;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;CatSper complex#GO:0036128;intracellular organelle#GO:0043229;acrosomal vesicle#GO:0001669;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;transmembrane transporter complex#GO:1902495;plasma membrane protein complex#GO:0098797;calcium channel complex#GO:0034704;vesicle#GO:0031982;voltage-gated calcium channel complex#GO:0005891;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 ion channel#PC00133 HUMAN|HGNC=29312|UniProtKB=Q9HCL3 Q9HCL3 ZFP14 PTHR24377:SF940 IP01015P-RELATED ZINC FINGER PROTEIN 14 HOMOLOG DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=14882|UniProtKB=Q9NQ79 Q9NQ79 CRTAC1 PTHR16026:SF5 CARTILAGE ACIDIC PROTEIN 1 CARTILAGE ACIDIC PROTEIN 1 axon development#GO:0061564;neuron projection development#GO:0031175;cellular process#GO:0009987;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;nervous system development#GO:0007399;neuron differentiation#GO:0030182;developmental process#GO:0032502;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;neurogenesis#GO:0022008;cellular component organization#GO:0016043;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell development#GO:0048468;animal gross anatomical part developmental process#GO:0160108;cell recognition#GO:0008037;generation of neurons#GO:0048699;anatomical structure development#GO:0048856;neuron development#GO:0048666;system development#GO:0048731 HUMAN|HGNC=2910|UniProtKB=Q9NR61 Q9NR61 DLL4 PTHR24044:SF320 NOTCH LIGAND FAMILY MEMBER DELTA-LIKE PROTEIN 4 binding#GO:0005488;signaling receptor binding#GO:0005102;protein binding#GO:0005515 signal transduction#GO:0007165;cellular process#GO:0009987;negative regulation of response to stimulus#GO:0048585;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;negative regulation of cellular process#GO:0048523;negative regulation of Notch signaling pathway#GO:0045746;regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166;Notch signaling pathway#GO:0007219;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of cell communication#GO:0010646;negative regulation of signaling#GO:0023057;regulation of Notch signaling pathway#GO:0008593;regulation of signaling#GO:0023051;cell communication#GO:0007154;negative regulation of cell communication#GO:0010648 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 intercellular signal molecule#PC00207 Angiogenesis#P00005>Delta/Serrate#P00226;Notch signaling pathway#P00045>Delta#P01116 HUMAN|HGNC=6163|UniProtKB=P26012 P26012 ITGB8 PTHR10082:SF9 INTEGRIN BETA SUBUNIT INTEGRIN BETA-8 cell adhesion molecule binding#GO:0050839;signaling receptor binding#GO:0005102;binding#GO:0005488;protein-containing complex binding#GO:0044877;integrin binding#GO:0005178;protein binding#GO:0005515 cellular process#GO:0009987;signal transduction#GO:0007165;cell-cell adhesion#GO:0098609;biological regulation#GO:0065007;cell migration#GO:0016477;cell surface receptor signaling pathway#GO:0007166;cell adhesion mediated by integrin#GO:0033627;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;integrin-mediated signaling pathway#GO:0007229;signaling#GO:0023052;cell motility#GO:0048870;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cell adhesion#GO:0007155;cell-matrix adhesion#GO:0007160;cell-substrate adhesion#GO:0031589;cell communication#GO:0007154 focal adhesion#GO:0005925;cell-substrate junction#GO:0030055;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cell surface#GO:0009986;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;protein complex involved in cell adhesion#GO:0098636;membrane#GO:0016020;membrane protein complex#GO:0098796;anchoring junction#GO:0070161;integrin complex#GO:0008305;cell junction#GO:0030054;signaling receptor complex#GO:0043235 integrin#PC00126 Integrin signalling pathway#P00034>Integrin beta#P00931 HUMAN|HGNC=38877|UniProtKB=P0CI26 P0CI26 TRIM49C PTHR24103:SF637 E3 UBIQUITIN-PROTEIN LIGASE TRIM TRIPARTITE MOTIF-CONTAINING PROTEIN 49-RELATED aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746 immune system process#GO:0002376;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;innate immune response#GO:0045087;response to external stimulus#GO:0009605;regulation of gene expression#GO:0010468;defense response#GO:0006952;defense response to other organism#GO:0098542;biological regulation#GO:0065007;response to other organism#GO:0051707;response to biotic stimulus#GO:0009607;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;response to stress#GO:0006950;defense response to symbiont#GO:0140546;immune response#GO:0006955 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=11548|UniProtKB=Q5H9L4 Q5H9L4 TAF7L PTHR12228:SF8 TRANSCRIPTION INITIATION FACTOR TFIID 55 KD SUBUNIT-RELATED TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 7-LIKE cellular component assembly#GO:0022607;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;protein-DNA complex assembly#GO:0065004;cellular component biogenesis#GO:0044085;transcription initiation at RNA polymerase II promoter#GO:0006367;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein-DNA complex organization#GO:0071824;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-containing complex organization#GO:0043933;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;transcription by RNA polymerase II#GO:0006366;DNA-templated transcription initiation#GO:0006352;RNA biosynthetic process#GO:0032774;RNA polymerase II preinitiation complex assembly#GO:0051123;DNA-templated transcription#GO:0006351;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;protein-containing complex assembly#GO:0065003;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187 RNA polymerase II transcription regulator complex#GO:0090575;membrane-enclosed lumen#GO:0031974;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;protein-containing complex#GO:0032991;transcription factor TFIID complex#GO:0005669;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;transcription regulator complex#GO:0005667;intracellular protein-containing complex#GO:0140535;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;RNA polymerase II, holoenzyme#GO:0016591;membrane-bounded organelle#GO:0043227;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622 general transcription factor#PC00259 HUMAN|HGNC=33888|UniProtKB=P0C6C1 P0C6C1 ANKRD34C PTHR24157:SF0 ANKYRIN REPEAT, SAM AND BASIC LEUCINE ZIPPER DOMAIN-CONTAINING PROTEIN 1 ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 34C cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=2363|UniProtKB=P46109 P46109 CRKL PTHR19969:SF23 SH2-SH3 ADAPTOR PROTEIN-RELATED CRK-LIKE PROTEIN protein binding#GO:0005515;signaling adaptor activity#GO:0035591;protein-macromolecule adaptor activity#GO:0030674;kinase binding#GO:0019900;binding#GO:0005488;signaling receptor binding#GO:0005102;protein tyrosine kinase binding#GO:1990782;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;molecular adaptor activity#GO:0060090;receptor tyrosine kinase binding#GO:0030971 regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;cell communication#GO:0007154;positive regulation of signaling#GO:0023056;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;signaling#GO:0023052;regulation of cell communication#GO:0010646;positive regulation of ERK1 and ERK2 cascade#GO:0070374;response to stimulus#GO:0050896;cell motility#GO:0048870;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;positive regulation of intracellular signal transduction#GO:1902533;regulation of MAPK cascade#GO:0043408;cell surface receptor signaling pathway#GO:0007166;regulation of response to stimulus#GO:0048583;positive regulation of MAPK cascade#GO:0043410;positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of ERK1 and ERK2 cascade#GO:0070372;positive regulation of response to stimulus#GO:0048584;cell migration#GO:0016477 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 Angiogenesis#P00005>Crk#P00207;Integrin signalling pathway#P00034>Crk#P00933 HUMAN|HGNC=18159|UniProtKB=Q9NNX9 Q9NNX9 VCX3A PTHR15251:SF3 TESTIS-SPECIFIC BASIC PROTEIN Y 1-RELATED TESTIS-SPECIFIC BASIC PROTEIN Y 1-RELATED anatomical structure development#GO:0048856;animal organ development#GO:0048513;multicellular organism development#GO:0007275;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502;multicellular organismal process#GO:0032501;brain development#GO:0007420;central nervous system development#GO:0007417;head development#GO:0060322;nervous system development#GO:0007399 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=7601|UniProtKB=Q8NEV4 Q8NEV4 MYO3A PTHR46256:SF4 AGAP011099-PA MYOSIN-IIIA kinase activity#GO:0016301;macromolecular conformation isomerase activity#GO:0120543;transferase activity, transferring phosphorus-containing groups#GO:0016772;microfilament motor activity#GO:0000146;catalytic activity#GO:0003824;transferase activity#GO:0016740;isomerase activity#GO:0016853;cytoskeletal motor activity#GO:0003774;catalytic activity, acting on a protein#GO:0140096;ATP-dependent activity#GO:0140657;protein serine/threonine kinase activity#GO:0004674;polypeptide conformation or assembly isomerase activity#GO:0120544;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 regulation of anatomical structure size#GO:0090066;cellular component organization or biogenesis#GO:0071840;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of cellular component biogenesis#GO:0044089;regulation of actin cytoskeleton organization#GO:0032956;regulation of actin filament length#GO:0030832;positive regulation of cellular component organization#GO:0051130;nervous system process#GO:0050877;regulation of biological quality#GO:0065008;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of cellular component size#GO:0032535;regulation of organelle organization#GO:0033043;regulation of plasma membrane bounded cell projection assembly#GO:0120032;regulation of cellular component organization#GO:0051128;sensory perception of sound#GO:0007605;regulation of cellular component biogenesis#GO:0044087;regulation of cell projection organization#GO:0031344;regulation of actin filament-based process#GO:0032970;regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of filopodium assembly#GO:0051489;system process#GO:0003008;positive regulation of cellular process#GO:0048522;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;sensory perception of mechanical stimulus#GO:0050954;sensory perception#GO:0007600;positive regulation of cell projection organization#GO:0031346;regulation of cell projection assembly#GO:0060491;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794 intracellular anatomical structure#GO:0005622;cluster of actin-based cell projections#GO:0098862;photoreceptor inner segment#GO:0001917;filopodium#GO:0030175;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;actin cytoskeleton#GO:0015629;actin-based cell projection#GO:0098858;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;stereocilium#GO:0032420;intracellular membraneless organelle#GO:0043232;neuron projection#GO:0043005 Cytoskeletal regulation by Rho GTPase#P00016>Myosin#P00522;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Myosin#P00867;Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HUMAN|HGNC=21460|UniProtKB=Q8TD10 Q8TD10 MIPOL1 PTHR22089:SF2 MIRROR-IMAGE POLYDACTYLY GENE 1 PROTEIN MIRROR-IMAGE POLYDACTYLY GENE 1 PROTEIN HUMAN|HGNC=35121|UniProtKB=A6NGY3 A6NGY3 C5orf52 PTHR35666:SF1 SIMILAR TO RIKEN CDNA 4921536K21 SIMILAR TO HUMAN CHROMOSOME 5 OPEN READING FRAME 52 HUMAN|HGNC=6524|UniProtKB=P06239 P06239 LCK PTHR24418:SF39 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE LCK protein kinase activity#GO:0004672;protein binding#GO:0005515;phosphotransferase activity, alcohol group as acceptor#GO:0016773;non-membrane spanning protein tyrosine kinase activity#GO:0004715;binding#GO:0005488;signaling receptor binding#GO:0005102;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;protein tyrosine kinase activity#GO:0004713;catalytic activity#GO:0003824;transferase activity#GO:0016740 leukocyte activation#GO:0045321;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;immune response-activating cell surface receptor signaling pathway#GO:0002429;cell activation#GO:0001775;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;lymphocyte differentiation#GO:0030098;regulation of immune response#GO:0050776;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;multicellular organismal process#GO:0032501;positive regulation of response to stimulus#GO:0048584;immune response-regulating cell surface receptor signaling pathway#GO:0002768;hemopoiesis#GO:0030097;biological regulation#GO:0065007;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;developmental process#GO:0032502;cellular developmental process#GO:0048869;leukocyte differentiation#GO:0002521;T cell activation#GO:0042110;immune response-regulating signaling pathway#GO:0002764;mononuclear cell differentiation#GO:1903131;regulation of biological process#GO:0050789;cell differentiation#GO:0030154;response to stimulus#GO:0050896;cell development#GO:0048468;signaling#GO:0023052;immune system process#GO:0002376;positive regulation of immune system process#GO:0002684;cellular process#GO:0009987;B cell receptor signaling pathway#GO:0050853;activation of immune response#GO:0002253;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;antigen receptor-mediated signaling pathway#GO:0050851;lymphocyte activation#GO:0046649;T cell differentiation#GO:0030217;cell surface receptor signaling pathway#GO:0007166;immune response-activating signaling pathway#GO:0002757 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 non-receptor tyrosine protein kinase#PC00168 T cell activation#P00053>Lck#P01310;Parkinson disease#P00049>Src kinase#P01230 HUMAN|HGNC=8676|UniProtKB=Q9H158 Q9H158 PCDHAC1 PTHR24028:SF236 CADHERIN-87A PROTOCADHERIN ALPHA-C1 cellular process#GO:0009987;cell adhesion#GO:0007155 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HUMAN|HGNC=14543|UniProtKB=Q9BYP7 Q9BYP7 WNK3 PTHR13902:SF47 SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED SERINE_THREONINE-PROTEIN KINASE WNK3 protein kinase activity#GO:0004672;molecular function inhibitor activity#GO:0140678;channel regulator activity#GO:0016247;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transporter regulator activity#GO:0141108;potassium channel regulator activity#GO:0015459;protein serine/threonine kinase activity#GO:0004674;molecular function regulator activity#GO:0098772;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;ion channel inhibitor activity#GO:0008200;ion channel regulator activity#GO:0099106 regulation of localization#GO:0032879;regulation of transport#GO:0051049;regulation of monoatomic cation transmembrane transport#GO:1904062;chemical homeostasis#GO:0048878;regulation of monoatomic ion transport#GO:0043269;biological regulation#GO:0065007;monoatomic ion homeostasis#GO:0050801;positive regulation of transport#GO:0051050;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of cellular process#GO:0048522;regulation of monoatomic ion transmembrane transport#GO:0034765;cellular process#GO:0009987;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;response to stimulus#GO:0050896;regulation of metal ion transport#GO:0010959;negative regulation of transport#GO:0051051;regulation of cellular process#GO:0050794;homeostatic process#GO:0042592;signaling#GO:0023052;negative regulation of biological process#GO:0048519;regulation of transmembrane transport#GO:0034762;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=25143|UniProtKB=Q86UD5 Q86UD5 SLC9B2 PTHR31102:SF14 FAMILY NOT NAMED SODIUM_HYDROGEN EXCHANGER 9B2 cellular process#GO:0009987;transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085 HUMAN|HGNC=23723|UniProtKB=Q5T4B2 Q5T4B2 CERCAM PTHR10730:SF9 PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER INACTIVE GLYCOSYLTRANSFERASE 25 FAMILY MEMBER 3 transferase activity#GO:0016740;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;catalytic activity, acting on a protein#GO:0140096;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;galactosyltransferase activity#GO:0008378 protein modifying enzyme#PC00260 HUMAN|HGNC=13128|UniProtKB=Q9Y462 Q9Y462 ZNF711 PTHR16515:SF76 PR DOMAIN ZINC FINGER PROTEIN ZINC FINGER PROTEIN 711-RELATED regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244;DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=20639|UniProtKB=P59551 P59551 TAS2R60 PTHR11394:SF32 TASTE RECEPTOR TYPE 2 TASTE RECEPTOR TYPE 2 MEMBER 60 signaling receptor activity#GO:0038023;taste receptor activity#GO:0008527;bitter taste receptor activity#GO:0033038;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 sensory perception of bitter taste#GO:0050913;detection of chemical stimulus#GO:0009593;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;response to stimulus#GO:0050896;response to chemical#GO:0042221;multicellular organismal process#GO:0032501;sensory perception#GO:0007600;nervous system process#GO:0050877;detection of chemical stimulus involved in sensory perception of taste#GO:0050912;sensory perception of taste#GO:0050909;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;detection of chemical stimulus involved in sensory perception of bitter taste#GO:0001580 membrane#GO:0016020;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=841|UniProtKB=P05496 P05496 ATP5MC1 PTHR10031:SF56 ATP SYNTHASE LIPID-BINDING PROTEIN, MITOCHONDRIAL ATP SYNTHASE F(0) COMPLEX SUBUNIT C1, MITOCHONDRIAL primary active transporter#PC00068;transporter#PC00227;ATP synthase#PC00002 HUMAN|HGNC=29271|UniProtKB=Q9P2E3 Q9P2E3 ZNFX1 PTHR10887:SF341 DNA2/NAM7 HELICASE FAMILY NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;heterochromatin formation#GO:0031507;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;regulatory ncRNA-mediated heterochromatin formation#GO:0031048;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;epigenetic regulation of gene expression#GO:0040029;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;cellular component assembly#GO:0022607;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;chromatin organization#GO:0006325;heterochromatin organization#GO:0070828;negative regulation of cellular process#GO:0048523;regulatory ncRNA-mediated gene silencing#GO:0031047;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;negative regulation of gene expression, epigenetic#GO:0045814;regulation of gene expression#GO:0010468 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695 RNA helicase#PC00032 HUMAN|HGNC=3661|UniProtKB=P02671 P02671 FGA PTHR47221:SF3 FIBRINOGEN ALPHA CHAIN FIBRINOGEN ALPHA CHAIN protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 metabolic process#GO:0008152;platelet aggregation#GO:0070527;negative regulation of response to wounding#GO:1903035;response to stress#GO:0006950;cell-cell adhesion#GO:0098609;positive regulation of cell-cell adhesion#GO:0022409;regulation of response to wounding#GO:1903034;cellular process#GO:0009987;coagulation#GO:0050817;positive regulation of biological process#GO:0048518;protein maturation#GO:0051604;regulation of response to external stimulus#GO:0032101;gene expression#GO:0010467;fibrinolysis#GO:0042730;regulation of multicellular organismal process#GO:0051239;negative regulation of response to external stimulus#GO:0032102;negative regulation of hemostasis#GO:1900047;cell adhesion#GO:0007155;negative regulation of coagulation#GO:0050819;protein activation cascade#GO:0072376;regulation of biological quality#GO:0065008;wound healing#GO:0042060;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of body fluid levels#GO:0050878;response to stimulus#GO:0050896;regulation of blood coagulation#GO:0030193;regulation of wound healing#GO:0061041;regulation of response to stress#GO:0080134;negative regulation of blood coagulation#GO:0030195;regulation of response to stimulus#GO:0048583;macromolecule metabolic process#GO:0043170;platelet activation#GO:0030168;blood coagulation#GO:0007596;negative regulation of wound healing#GO:0061045;response to wounding#GO:0009611;regulation of hemostasis#GO:1900046;macromolecule biosynthetic process#GO:0009059;positive regulation of cellular process#GO:0048522;regulation of cell adhesion#GO:0030155;negative regulation of response to stimulus#GO:0048585;multicellular organismal process#GO:0032501;regulation of coagulation#GO:0050818;homotypic cell-cell adhesion#GO:0034109;biosynthetic process#GO:0009058;biological regulation#GO:0065007;cell activation#GO:0001775;blood coagulation, fibrin clot formation#GO:0072378;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;hemostasis#GO:0007599;negative regulation of multicellular organismal process#GO:0051241;positive regulation of cell adhesion#GO:0045785;regulation of cell-cell adhesion#GO:0022407;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;extracellular protein-containing complex#GO:0140392;extracellular region#GO:0005576 Plasminogen activating cascade#P00050>Fibrin C-terminal truncation#P01258;Plasminogen activating cascade#P00050>Fibrin#P01253;Blood coagulation#P00011>Fibrin monomer#P00418;Blood coagulation#P00011>Fibrin polymer cross-linked#P00443;Blood coagulation#P00011>Fibrinogen#P00406 HUMAN|HGNC=27269|UniProtKB=Q6ZQW0 Q6ZQW0 IDO2 PTHR28657:SF4 INDOLEAMINE 2,3-DIOXYGENASE INDOLEAMINE 2,3-DIOXYGENASE 2 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen#GO:0016702;oxidoreductase activity#GO:0016491;dioxygenase activity#GO:0051213;catalytic activity#GO:0003824 pyridine-containing compound metabolic process#GO:0072524;oxoacid metabolic process#GO:0043436;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;nucleotide biosynthetic process#GO:0009165;organophosphate biosynthetic process#GO:0090407;nucleotide metabolic process#GO:0009117;indole-containing compound metabolic process#GO:0042430;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;small molecule catabolic process#GO:0044282;nucleoside phosphate metabolic process#GO:0006753;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;nucleoside phosphate biosynthetic process#GO:1901293;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;nicotinamide nucleotide metabolic process#GO:0046496;organophosphate metabolic process#GO:0019637;NAD+ metabolic process#GO:0019674;amino acid metabolic process#GO:0006520;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;proteinogenic amino acid metabolic process#GO:0170039 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 oxygenase#PC00177 HUMAN|HGNC=26545|UniProtKB=A6NI28 A6NI28 ARHGAP42 PTHR12552:SF3 OLIGOPHRENIN 1 RHO GTPASE-ACTIVATING PROTEIN 42 enzyme activator activity#GO:0008047;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772 GTPase-activating protein#PC00257 PDGF signaling pathway#P00047>Rho#P01174 HUMAN|HGNC=16827|UniProtKB=O75794 O75794 CDC123 PTHR15323:SF6 D123 PROTEIN TRANSLATION INITIATION FACTOR EIF2 ASSEMBLY PROTEIN cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;cellular component assembly#GO:0022607;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=15815|UniProtKB=Q7Z478 Q7Z478 DHX29 PTHR18934:SF264 ATP-DEPENDENT RNA HELICASE ATP-DEPENDENT RNA HELICASE DHX29 catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;macromolecular conformation isomerase activity#GO:0120543;helicase activity#GO:0004386;isomerase activity#GO:0016853;binding#GO:0005488;nucleic acid binding#GO:0003676;ATP-dependent activity#GO:0140657;RNA binding#GO:0003723 RNA helicase#PC00032;RNA metabolism protein#PC00031 HUMAN|HGNC=18042|UniProtKB=Q96LI5 Q96LI5 CNOT6L PTHR12121:SF35 CARBON CATABOLITE REPRESSOR PROTEIN 4 CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 6-LIKE nuclease activity#GO:0004518;hydrolase activity#GO:0016787;3'-5'-RNA exonuclease activity#GO:0000175;exonuclease activity#GO:0004527;catalytic activity, acting on RNA#GO:0140098;3'-5' exonuclease activity#GO:0008408;RNA nuclease activity#GO:0004540;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640 regulation of nucleobase-containing compound metabolic process#GO:0019219;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of primary metabolic process#GO:0080090;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;nucleic acid catabolic process#GO:0141188;macromolecule metabolic process#GO:0043170;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;positive regulation of catabolic process#GO:0009896;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;nuclear-transcribed mRNA poly(A) tail shortening#GO:0000289;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;positive regulation of mRNA catabolic process#GO:0061014;regulation of RNA metabolic process#GO:0051252;regulation of RNA stability#GO:0043487;positive regulation of macromolecule metabolic process#GO:0010604;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;RNA destabilization#GO:0050779;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of mRNA metabolic process#GO:1903311;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;mRNA destabilization#GO:0061157;positive regulation of mRNA metabolic process#GO:1903313;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;regulation of mRNA stability#GO:0043488;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;positive regulation of metabolic process#GO:0009893;RNA metabolic process#GO:0016070;regulation of biological quality#GO:0065008;RNA catabolic process#GO:0006401 CCR4-NOT complex#GO:0030014;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227 mRNA polyadenylation factor#PC00146 HUMAN|HGNC=7513|UniProtKB=Q02505 Q02505 MUC3A PTHR24041:SF22 MUCIN MUCIN-3A-RELATED cell adhesion molecule#PC00069 HUMAN|HGNC=10521|UniProtKB=P10523 P10523 SAG PTHR11792:SF15 ARRESTIN S-ARRESTIN binding#GO:0005488;signaling receptor binding#GO:0005102;G protein-coupled receptor binding#GO:0001664;protein binding#GO:0005515 system process#GO:0003008;receptor-mediated endocytosis#GO:0006898;establishment of localization#GO:0051234;import into cell#GO:0098657;regulation of G protein-coupled receptor signaling pathway#GO:0008277;transport#GO:0006810;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of response to stimulus#GO:0048585;multicellular organismal process#GO:0032501;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;receptor internalization#GO:0031623;negative regulation of cell communication#GO:0010648;localization#GO:0051179;regulation of signaling#GO:0023051;nervous system process#GO:0050877;sensory perception#GO:0007600;negative regulation of signaling#GO:0023057;regulation of cell communication#GO:0010646;endocytosis#GO:0006897;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of G protein-coupled receptor signaling pathway#GO:0045744;negative regulation of biological process#GO:0048519 9+0 non-motile cilium#GO:0097731;photoreceptor cell cilium#GO:0097733;neuron projection#GO:0043005;cellular anatomical structure#GO:0110165;organelle#GO:0043226;photoreceptor outer segment#GO:0001750;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;cell projection#GO:0042995;photoreceptor inner segment#GO:0001917;cilium#GO:0005929;non-motile cilium#GO:0097730;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 scaffold/adaptor protein#PC00226 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>beta-arrestin#P00757;Wnt signaling pathway#P00057>beta-arrestin#P01456 HUMAN|HGNC=26556|UniProtKB=Q8N4P6 Q8N4P6 LRRC71 PTHR46984:SF1 LEUCINE-RICH REPEAT-CONTAINING PROTEIN 71 LEUCINE-RICH REPEAT-CONTAINING PROTEIN 71 HUMAN|HGNC=27329|UniProtKB=Q9Y3T6 Q9Y3T6 R3HCC1 PTHR21678:SF6 GROWTH INHIBITION AND DIFFERENTIATION RELATED PROTEIN 88 R3H AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1 HUMAN|HGNC=19990|UniProtKB=Q9UJX5 Q9UJX5 ANAPC4 PTHR13260:SF0 ANAPHASE PROMOTING COMPLEX SUBUNIT 4 APC4 ANAPHASE-PROMOTING COMPLEX SUBUNIT 4 catabolic process#GO:0009056;protein modification process#GO:0036211;primary metabolic process#GO:0044238;protein K11-linked ubiquitination#GO:0070979;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;modification-dependent protein catabolic process#GO:0019941;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein modification by small protein conjugation or removal#GO:0070647;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;anaphase-promoting complex-dependent catabolic process#GO:0031145;post-translational protein modification#GO:0043687;proteasomal protein catabolic process#GO:0010498;protein ubiquitination#GO:0016567;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152 ubiquitin ligase complex#GO:0000151;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;nuclear periphery#GO:0034399;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nuclear ubiquitin ligase complex#GO:0000152;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cullin-RING ubiquitin ligase complex#GO:0031461;organelle lumen#GO:0043233;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;anaphase-promoting complex#GO:0005680;protein-containing complex#GO:0032991;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 HUMAN|HGNC=25625|UniProtKB=Q9NV23 Q9NV23 OLAH PTHR11487:SF0 THIOESTERASE S-ACYL FATTY ACID SYNTHASE THIOESTERASE, MEDIUM CHAIN biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;cellular process#GO:0009987;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;primary metabolic process#GO:0044238 esterase#PC00097;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=32955|UniProtKB=Q6NSI1 Q6NSI1 ANKRD26P1 PTHR24147:SF60 ANKYRIN REPEAT DOMAIN 36-RELATED ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 26-RELATED HUMAN|HGNC=14569|UniProtKB=Q9UK76 Q9UK76 JPT1 PTHR34930:SF4 GEO05313P1 JUPITER MICROTUBULE ASSOCIATED HOMOLOG 1 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=25297|UniProtKB=Q6ZN04 Q6ZN04 MEX3B PTHR23285:SF5 RING FINGER AND KH DOMAIN CONTAINING PROTEIN 1 RNA-BINDING PROTEIN MEX3B RNA metabolism protein#PC00031 HUMAN|HGNC=17347|UniProtKB=Q9BUQ8 Q9BUQ8 DDX23 PTHR47958:SF96 ATP-DEPENDENT RNA HELICASE DBP3 ATP-DEPENDENT RNA HELICASE DDX23-RELATED nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;ATP-dependent activity#GO:0140657;RNA binding#GO:0003723;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;RNA helicase activity#GO:0003724;nucleic acid conformation isomerase activity#GO:0120545;macromolecular conformation isomerase activity#GO:0120543;helicase activity#GO:0004386;catalytic activity, acting on RNA#GO:0140098;isomerase activity#GO:0016853 mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;catalytic step 2 spliceosome#GO:0071013;nuclear protein-containing complex#GO:0140513;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;spliceosomal complex#GO:0005681 RNA helicase#PC00032 HUMAN|HGNC=15979|UniProtKB=Q9H3D4 Q9H3D4 TP63 PTHR11447:SF8 CELLULAR TUMOR ANTIGEN P53 TUMOR PROTEIN 63 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;chromatin binding#GO:0003682;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 signal transduction by p53 class mediator#GO:0072331;cellular response to stress#GO:0033554;intrinsic apoptotic signaling pathway#GO:0097193;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of programmed cell death#GO:0043067;apoptotic process#GO:0006915;regulation of biological process#GO:0050789;intrinsic apoptotic signaling pathway by p53 class mediator#GO:0072332;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;signaling#GO:0023052;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of apoptotic process#GO:0042981;response to stress#GO:0006950;intrinsic apoptotic signaling pathway in response to DNA damage#GO:0008630;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604;regulation of DNA-templated transcription#GO:0006355;cell communication#GO:0007154;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;intracellular signal transduction#GO:0035556;programmed cell death#GO:0012501;intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator#GO:0042771;cellular response to stimulus#GO:0051716;cell death#GO:0008219;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;DNA damage response#GO:0006974;apoptotic signaling pathway#GO:0097190;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680 intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;chromosome#GO:0005694;chromatin#GO:0000785;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232 P53-like transcription factor#PC00253;gene-specific transcriptional regulator#PC00264 Huntington disease#P00029>p53#P00797;p53 pathway#P00059>p53#P01485;p53 pathway feedback loops 2#P04398>p53#P04668;P53 pathway feedback loops 1#P04392>p73DeltaN#G04685;P53 pathway feedback loops 1#P04392>p73DeltaN#P04537;p53 pathway#P00059>p53#G04702;P53 pathway feedback loops 1#P04392>p53#P04539;p53 pathway by glucose deprivation#P04397>p53#P04640 HUMAN|HGNC=3383|UniProtKB=P27105 P27105 STOM PTHR10264:SF115 BAND 7 PROTEIN-RELATED STOMATIN molecular function regulator activity#GO:0098772;channel regulator activity#GO:0016247;molecular function inhibitor activity#GO:0140678;ion channel inhibitor activity#GO:0008200;ion channel regulator activity#GO:0099106;transporter regulator activity#GO:0141108 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cytoskeletal protein#PC00085 HUMAN|HGNC=16648|UniProtKB=Q8NG27 Q8NG27 PJA1 PTHR15710:SF2 E3 UBIQUITIN-PROTEIN LIGASE PRAJA E3 UBIQUITIN-PROTEIN LIGASE PRAJA-1 regulation of intracellular signal transduction#GO:1902531;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of signaling#GO:0023056;positive regulation of signal transduction#GO:0009967;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;positive regulation of biological process#GO:0048518;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;positive regulation of response to stimulus#GO:0048584;regulation of cell communication#GO:0010646;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=14737|UniProtKB=Q8NH79 Q8NH79 OR6X1 PTHR26454:SF30 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 6X1 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=16422|UniProtKB=Q9BWT7 Q9BWT7 CARD10 PTHR14559:SF12 CASPASE RECRUITMENT DOMAIN FAMILY CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 10 signaling adaptor activity#GO:0035591;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of immune system process#GO:0002682;response to stimulus#GO:0050896;regulation of cell communication#GO:0010646;signaling#GO:0023052;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;positive regulation of signaling#GO:0023056;cell communication#GO:0007154;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;regulation of immune response#GO:0050776;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;cellular process#GO:0009987;regulation of canonical NF-kappaB signal transduction#GO:0043122;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of canonical NF-kappaB signal transduction#GO:0043123;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HUMAN|HGNC=7226|UniProtKB=O95297 O95297 MPZL1 PTHR13869:SF19 MYELIN P0 RELATED MYELIN PROTEIN ZERO-LIKE PROTEIN 1 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 myelin protein#PC00161 HUMAN|HGNC=1770|UniProtKB=Q15131 Q15131 CDK10 PTHR24056:SF508 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE 10 kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 mitotic cell cycle#GO:0000278;regulation of cellular process#GO:0050794;G2/M transition of mitotic cell cycle#GO:0000086;cell cycle phase transition#GO:0044770;regulation of cell cycle#GO:0051726;cell cycle#GO:0007049;regulation of cell cycle phase transition#GO:1901987;regulation of biological process#GO:0050789;cell cycle process#GO:0022402;mitotic cell cycle phase transition#GO:0044772;biological regulation#GO:0065007;regulation of cell cycle process#GO:0010564;regulation of cell cycle G2/M phase transition#GO:1902749;cell cycle G2/M phase transition#GO:0044839;cellular process#GO:0009987;mitotic cell cycle process#GO:1903047 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=28299|UniProtKB=Q6NUT3 Q6NUT3 MFSD12 PTHR11328:SF50 MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 12 L-amino acid transmembrane transporter activity#GO:0015179;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;carboxylic acid transmembrane transporter activity#GO:0046943;neutral L-amino acid transmembrane transporter activity#GO:0015175;amino acid transmembrane transporter activity#GO:0015171 biological regulation#GO:0065007;cellular process#GO:0009987;L-amino acid transport#GO:0015807;regulation of metabolic process#GO:0019222;nitrogen compound transport#GO:0071705;pigment metabolic process#GO:0042440;establishment of localization#GO:0051234;regulation of biosynthetic process#GO:0009889;organic acid transport#GO:0015849;amino acid transport#GO:0006865;transport#GO:0006810;carboxylic acid transport#GO:0046942;metabolic process#GO:0008152;carboxylic acid transmembrane transport#GO:1905039;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;L-alpha-amino acid transmembrane transport#GO:1902475;localization#GO:0051179;neutral amino acid transport#GO:0015804;transmembrane transport#GO:0055085;amino acid transmembrane transport#GO:0003333;pigmentation#GO:0043473 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 primary active transporter#PC00068 HUMAN|HGNC=2938|UniProtKB=Q8TDJ6 Q8TDJ6 DMXL2 PTHR13950:SF13 RABCONNECTIN-RELATED DMX-LIKE PROTEIN 2 protein-containing complex organization#GO:0043933;regulation of transport#GO:0051049;regulation of localization#GO:0032879;endosomal transport#GO:0016197;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;transport#GO:0006810;intracellular transport#GO:0046907;regulation of monoatomic cation transmembrane transport#GO:1904062;biological regulation#GO:0065007;vesicle-mediated transport#GO:0016192;regulation of monoatomic ion transport#GO:0043269;cellular component assembly#GO:0022607;regulation of monoatomic ion transmembrane transport#GO:0034765;cellular process#GO:0009987;early endosome to late endosome transport#GO:0045022;establishment of localization in cell#GO:0051649;cellular component biogenesis#GO:0044085;cellular localization#GO:0051641;localization#GO:0051179;regulation of cellular process#GO:0050794;protein-containing complex assembly#GO:0065003;regulation of biological process#GO:0050789;regulation of transmembrane transport#GO:0034762;cellular component organization#GO:0016043 organelle#GO:0043226;cellular anatomical structure#GO:0110165;synapse#GO:0045202;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;synaptic vesicle#GO:0008021;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;transport vesicle#GO:0030133;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;secretory vesicle#GO:0099503;presynapse#GO:0098793;cell junction#GO:0030054 HUMAN|HGNC=20189|UniProtKB=Q9NVL8 Q9NVL8 CCDC198 PTHR16065:SF2 COILED-COIL DOMAIN CONTAINING 198 FACTOR ASSOCIATED WITH METABOLISM AND ENERGY HUMAN|HGNC=13464|UniProtKB=Q9NRX5 Q9NRX5 SERINC1 PTHR10383:SF15 SERINE INCORPORATOR SERINE INCORPORATOR 1 membrane#GO:0016020;cellular anatomical structure#GO:0110165 protein-binding activity modulator#PC00095 HUMAN|HGNC=33469|UniProtKB=Q30KR1 Q30KR1 DEFB109B PTHR20515:SF3 BETA-DEFENSIN BETA-DEFENSIN 109B molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;G protein-coupled receptor binding#GO:0001664;protein binding#GO:0005515;chemokine receptor binding#GO:0042379;molecular function activator activity#GO:0140677;signaling receptor binding#GO:0005102;cytokine receptor binding#GO:0005126;binding#GO:0005488 biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;locomotion#GO:0040011;response to stimulus#GO:0050896;cell motility#GO:0048870;cellular response to stimulus#GO:0051716;cell chemotaxis#GO:0060326;defense response to bacterium#GO:0042742;chemotaxis#GO:0006935;cellular response to chemical stimulus#GO:0070887;response to bacterium#GO:0009617;response to other organism#GO:0051707;response to chemical#GO:0042221;taxis#GO:0042330;cell migration#GO:0016477;cellular process#GO:0009987;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;response to external stimulus#GO:0009605;defense response#GO:0006952 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090;antimicrobial response protein#PC00051 HUMAN|HGNC=41911|UniProtKB=Q6ZU69 Q6ZU69 SPATA31F1 PTHR21859:SF15 ACROSOME-SPECIFIC PROTEIN PROTEIN SPATA31F1-RELATED HUMAN|HGNC=16905|UniProtKB=O60662 O60662 KLHL41 PTHR24412:SF146 KELCH PROTEIN KELCH-LIKE PROTEIN 41 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;enzyme-substrate adaptor activity#GO:0140767;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;regulation of cell differentiation#GO:0045595;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;cellular process#GO:0009987;biological regulation#GO:0065007;proteasomal protein catabolic process#GO:0010498;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;regulation of cell population proliferation#GO:0042127;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;regulation of developmental process#GO:0050793 endoplasmic reticulum#GO:0005783;bounding membrane of organelle#GO:0098588;sarcomere#GO:0030017;Cul3-RING ubiquitin ligase complex#GO:0031463;contractile muscle fiber#GO:0043292;sarcoplasmic reticulum#GO:0016529;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;sarcoplasmic reticulum membrane#GO:0033017;supramolecular complex#GO:0099080;intracellular organelle#GO:0043229;M band#GO:0031430;organelle subcompartment#GO:0031984;supramolecular fiber#GO:0099512;ubiquitin ligase complex#GO:0000151;myofibril#GO:0030016;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;transferase complex#GO:1990234;endoplasmic reticulum membrane#GO:0005789;cytoskeleton#GO:0005856;intracellular protein-containing complex#GO:0140535;organelle membrane#GO:0031090;membraneless organelle#GO:0043228;membrane#GO:0016020;endomembrane system#GO:0012505;endoplasmic reticulum subcompartment#GO:0098827;catalytic complex#GO:1902494;sarcoplasm#GO:0016528;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;A band#GO:0031672;intracellular membrane-bounded organelle#GO:0043231;cullin-RING ubiquitin ligase complex#GO:0031461 scaffold/adaptor protein#PC00226 HUMAN|HGNC=42540|UniProtKB=A8MVZ5 A8MVZ5 BTNL10P PTHR24100:SF133 BUTYROPHILIN BUTYROPHILIN-LIKE PROTEIN 10-RELATED signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515 regulation of macromolecule metabolic process#GO:0060255;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;immune response-activating cell surface receptor signaling pathway#GO:0002429;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;regulation of immune response#GO:0050776;positive regulation of response to stimulus#GO:0048584;immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007;regulation of cytokine production#GO:0001817;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;T cell receptor signaling pathway#GO:0050852;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;response to stimulus#GO:0050896;signaling#GO:0023052;regulation of biological process#GO:0050789;immune response-regulating signaling pathway#GO:0002764;immune system process#GO:0002376;antigen receptor-mediated signaling pathway#GO:0050851;regulation of multicellular organismal process#GO:0051239;positive regulation of immune system process#GO:0002684;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;signal transduction#GO:0007165;cellular process#GO:0009987;immune response-activating signaling pathway#GO:0002757;cell surface receptor signaling pathway#GO:0007166 cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020;plasma membrane#GO:0005886;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;cell surface#GO:0009986 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=25907|UniProtKB=Q96ST8 Q96ST8 CEP89 PTHR36170:SF1 CENTROSOMAL PROTEIN OF 89 KDA CENTROSOMAL PROTEIN OF 89 KDA cilium organization#GO:0044782;cellular component organization or biogenesis#GO:0071840;organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031;plasma membrane bounded cell projection organization#GO:0120036;mitochondrion organization#GO:0007005;cell projection organization#GO:0030030;cellular component assembly#GO:0022607;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component organization#GO:0016043;cilium assembly#GO:0060271;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085 intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;centriole#GO:0005814;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;ciliary transition fiber#GO:0097539;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cilium#GO:0005929;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=12461|UniProtKB=Q9NZ09 Q9NZ09 UBAP1 PTHR15960:SF2 LD44032P UBIQUITIN-ASSOCIATED PROTEIN 1 protein binding#GO:0005515;ubiquitin binding#GO:0043130;binding#GO:0005488 modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043162;catabolic process#GO:0009056 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;vesicle#GO:0031982;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768;endosome membrane#GO:0010008;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;vesicle membrane#GO:0012506;membrane#GO:0016020;ESCRT I complex#GO:0000813;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090 HUMAN|HGNC=1996|UniProtKB=P17540 P17540 CKMT2 PTHR11547:SF19 ARGININE OR CREATINE KINASE CREATINE KINASE S-TYPE, MITOCHONDRIAL kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;phosphotransferase activity, nitrogenous group as acceptor#GO:0016775 biosynthetic process#GO:0009058;organophosphate biosynthetic process#GO:0090407;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;metabolic process#GO:0008152;modified amino acid metabolic process#GO:0006575;phosphorus metabolic process#GO:0006793 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;extracellular region#GO:0005576;intracellular organelle#GO:0043229 metabolite interconversion enzyme#PC00262;amino acid kinase#PC00045 HUMAN|HGNC=25836|UniProtKB=Q6ZS17 Q6ZS17 RIPOR1 PTHR15829:SF1 PROTEIN KINASE PKN/PRK1, EFFECTOR RHO FAMILY-INTERACTING CELL POLARIZATION REGULATOR 1 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=18348|UniProtKB=Q8IUC6 Q8IUC6 TICAM1 PTHR47230:SF1 TIR DOMAIN-CONTAINING ADAPTER MOLECULE 1 TIR DOMAIN-CONTAINING ADAPTER MOLECULE 1 signaling adaptor activity#GO:0035591;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 positive regulation of response to external stimulus#GO:0032103;positive regulation of canonical NF-kappaB signal transduction#GO:0043123;immune response-activating signaling pathway#GO:0002757;regulation of response to external stimulus#GO:0032101;positive regulation of macromolecule metabolic process#GO:0010604;regulation of multicellular organismal process#GO:0051239;positive regulation of immune system process#GO:0002684;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;signal transduction#GO:0007165;positive regulation of signaling#GO:0023056;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of intracellular signal transduction#GO:1902531;immune system process#GO:0002376;regulation of signaling#GO:0023051;response to stimulus#GO:0050896;signaling#GO:0023052;toll-like receptor signaling pathway#GO:0002224;positive regulation of multicellular organismal process#GO:0051240;immune response-regulating signaling pathway#GO:0002764;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of innate immune response#GO:0045088;pattern recognition receptor signaling pathway#GO:0002221;regulation of gene expression#GO:0010468;positive regulation of response to biotic stimulus#GO:0002833;positive regulation of gene expression#GO:0010628;regulation of response to stress#GO:0080134;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of defense response#GO:0031349;positive regulation of response to stimulus#GO:0048584;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cytokine production#GO:0001817;activation of innate immune response#GO:0002218;regulation of canonical NF-kappaB signal transduction#GO:0043122;positive regulation of innate immune response#GO:0045089;positive regulation of cellular process#GO:0048522;positive regulation of biosynthetic process#GO:0009891;cell communication#GO:0007154;regulation of defense response#GO:0031347;regulation of immune response#GO:0050776;positive regulation of cytokine production#GO:0001819;positive regulation of cell communication#GO:0010647;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of response to biotic stimulus#GO:0002831;regulation of cell communication#GO:0010646;positive regulation of type I interferon production#GO:0032481;positive regulation of signal transduction#GO:0009967;innate immune response-activating signaling pathway#GO:0002758;cellular response to stimulus#GO:0051716 intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 scaffold/adaptor protein#PC00226 Toll receptor signaling pathway#P00054>TRIF#P01344 HUMAN|HGNC=2611|UniProtKB=P20853 P20853 CYP2A7 PTHR24300:SF297 CYTOCHROME P450 508A4-RELATED CYTOCHROME P450 2A7 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen#GO:0016712;oxidoreductase activity#GO:0016491;monooxygenase activity#GO:0004497;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;heme binding#GO:0020037;tetrapyrrole binding#GO:0046906;binding#GO:0005488 olefinic compound metabolic process#GO:0120254;oxoacid metabolic process#GO:0043436;cellular response to chemical stimulus#GO:0070887;response to xenobiotic stimulus#GO:0009410;arachidonate metabolic process#GO:0019369;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;xenobiotic metabolic process#GO:0006805;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;lipid metabolic process#GO:0006629;unsaturated fatty acid metabolic process#GO:0033559;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;secondary metabolic process#GO:0019748;cellular process#GO:0009987;long-chain fatty acid metabolic process#GO:0001676;cellular response to xenobiotic stimulus#GO:0071466;icosanoid metabolic process#GO:0006690;response to chemical#GO:0042221 intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 oxygenase#PC00177;oxidoreductase#PC00176 Nicotine degradation#P05914>CYP2A6#P05984 HUMAN|HGNC=12022|UniProtKB=P13693 P13693 TPT1 PTHR11991:SF9 TRANSLATIONALLY CONTROLLED TUMOR PROTEIN-RELATED TPT1-LIKE PROTEIN-RELATED cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167 negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;regulation of apoptotic signaling pathway#GO:2001233;negative regulation of apoptotic signaling pathway#GO:2001234;negative regulation of cell communication#GO:0010648;negative regulation of catabolic process#GO:0009895;regulation of programmed cell death#GO:0043067;regulation of autophagy#GO:0010506;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;negative regulation of metabolic process#GO:0009892;negative regulation of cellular process#GO:0048523;regulation of apoptotic process#GO:0042981;regulation of response to stimulus#GO:0048583;regulation of catabolic process#GO:0009894;negative regulation of autophagy#GO:0010507;regulation of metabolic process#GO:0019222;negative regulation of programmed cell death#GO:0043069;negative regulation of response to stimulus#GO:0048585;negative regulation of apoptotic process#GO:0043066;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 microtubule or microtubule-binding cytoskeletal protein#PC00157;non-motor microtubule binding protein#PC00166;cytoskeletal protein#PC00085 HUMAN|HGNC=19084|UniProtKB=Q86YT9 Q86YT9 JAML PTHR13869:SF22 MYELIN P0 RELATED JUNCTIONAL ADHESION MOLECULE-LIKE cell-cell adhesion#GO:0098609;cellular process#GO:0009987;cell adhesion#GO:0007155 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 myelin protein#PC00161 HUMAN|HGNC=11946|UniProtKB=P48788 P48788 TNNI2 PTHR13738:SF15 TROPONIN I TROPONIN I, FAST SKELETAL MUSCLE binding#GO:0005488;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515 system process#GO:0003008;heart contraction#GO:0060047;neuromuscular process#GO:0050905;cardiac muscle contraction#GO:0060048;muscle contraction#GO:0006936;nervous system process#GO:0050877;circulatory system process#GO:0003013;skeletal muscle contraction#GO:0003009;striated muscle contraction#GO:0006941;blood circulation#GO:0008015;multicellular organismal process#GO:0032501;muscle system process#GO:0003012;heart process#GO:0003015 contractile muscle fiber#GO:0043292;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;sarcomere#GO:0030017;actin cytoskeleton#GO:0015629;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;myofibril#GO:0030016;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512 non-motor actin binding protein#PC00165 HUMAN|HGNC=28763|UniProtKB=Q96HS1 Q96HS1 PGAM5 PTHR20935:SF0 PHOSPHOGLYCERATE MUTASE-RELATED SERINE_THREONINE-PROTEIN PHOSPHATASE PGAM5, MITOCHONDRIAL hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721;protein serine/threonine phosphatase activity#GO:0004722;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788 positive regulation of developmental process#GO:0051094;positive regulation of cellular component organization#GO:0051130;positive regulation of organelle organization#GO:0010638;regulation of anatomical structure morphogenesis#GO:0022603;regulation of organelle organization#GO:0033043;regulation of mitochondrion organization#GO:0010821;positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789;positive regulation of cellular process#GO:0048522;biological regulation#GO:0065007;regulation of mitochondrial fission#GO:0090140;positive regulation of mitochondrial fission#GO:0090141;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 mutase#PC00160;isomerase#PC00135 HUMAN|HGNC=2325|UniProtKB=Q9P2I0 Q9P2I0 CPSF2 PTHR45922:SF2 CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2 CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2 binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;mRNA 3'-end processing#GO:0031124;RNA 3'-end processing#GO:0031123;macromolecule metabolic process#GO:0043170 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;mRNA cleavage factor complex#GO:0005849;intracellular organelle#GO:0043229;mRNA cleavage and polyadenylation specificity factor complex#GO:0005847;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513 HUMAN|HGNC=5237|UniProtKB=P34932 P34932 HSPA4 PTHR45639:SF6 HSC70CB, ISOFORM G-RELATED HEAT SHOCK 70 KDA PROTEIN 4 nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;biosynthetic process#GO:0009058;protein folding#GO:0006457;protein maturation#GO:0051604;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 chaperone#PC00072;Hsp70 family chaperone#PC00027 HUMAN|HGNC=15748|UniProtKB=Q9UKY0 Q9UKY0 PRND PTHR15506:SF0 DOPPEL PRION PRION-LIKE PROTEIN DOPPEL transition metal ion binding#GO:0046914;binding#GO:0005488;copper ion binding#GO:0005507;small molecule binding#GO:0036094;ion binding#GO:0043167;cation binding#GO:0043169;metal ion binding#GO:0046872 sexual reproduction#GO:0019953;response to metal ion#GO:0010038;cellular response to chemical stimulus#GO:0070887;fertilization#GO:0009566;reproductive process#GO:0022414;response to stimulus#GO:0050896;response to chemical#GO:0042221;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;single fertilization#GO:0007338 membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HUMAN|HGNC=10480|UniProtKB=Q8N488 Q8N488 RYBP PTHR12920:SF3 RYBP AND YAF2-RELATED RING1 AND YY1-BINDING PROTEIN DNA binding#GO:0003677;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 transcription cofactor#PC00217 HUMAN|HGNC=11864|UniProtKB=O15321 O15321 TM9SF1 PTHR10766:SF177 TRANSMEMBRANE 9 SUPERFAMILY PROTEIN TRANSMEMBRANE 9 SUPERFAMILY MEMBER 1 localization within membrane#GO:0051668;cellular process#GO:0009987;macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657;intracellular protein localization#GO:0008104;localization#GO:0051179;cellular localization#GO:0051641 cellular anatomical structure#GO:0110165;membrane#GO:0016020 transporter#PC00227 HUMAN|HGNC=8542|UniProtKB=P51582 P51582 P2RY4 PTHR24231:SF21 PURINOCEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR P2Y PURINOCEPTOR 4 transmembrane signaling receptor activity#GO:0004888;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=30085|UniProtKB=Q9H7M9 Q9H7M9 VSIR PTHR44819:SF1 V-TYPE IMMUNOGLOBULIN DOMAIN-CONTAINING SUPPRESSOR OF T-CELL ACTIVATION V-TYPE IMMUNOGLOBULIN DOMAIN-CONTAINING SUPPRESSOR OF T-CELL ACTIVATION negative regulation of cellular process#GO:0048523;regulation of leukocyte cell-cell adhesion#GO:1903037;negative regulation of cell activation#GO:0050866;regulation of cell adhesion#GO:0030155;regulation of T cell activation#GO:0050863;negative regulation of cell-cell adhesion#GO:0022408;negative regulation of cell adhesion#GO:0007162;negative regulation of leukocyte activation#GO:0002695;regulation of multicellular organismal process#GO:0051239;negative regulation of lymphocyte activation#GO:0051250;biological regulation#GO:0065007;negative regulation of immune system process#GO:0002683;negative regulation of T cell activation#GO:0050868;regulation of leukocyte activation#GO:0002694;negative regulation of biological process#GO:0048519;negative regulation of multicellular organismal process#GO:0051241;regulation of cell activation#GO:0050865;regulation of biological process#GO:0050789;regulation of cell-cell adhesion#GO:0022407;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of lymphocyte activation#GO:0051249;negative regulation of leukocyte cell-cell adhesion#GO:1903038 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=20880|UniProtKB=Q86UL3 Q86UL3 GPAT4 PTHR23063:SF37 PHOSPHOLIPID ACYLTRANSFERASE GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE 4 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;acyltransferase#PC00042;transferase#PC00220 HUMAN|HGNC=17479|UniProtKB=Q96PM5 Q96PM5 RCHY1 PTHR21319:SF53 RING FINGER AND CHY ZINC FINGER DOMAIN-CONTAINING PROTEIN 1 RING FINGER AND CHY ZINC FINGER DOMAIN-CONTAINING PROTEIN 1 catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659 catabolic process#GO:0009056;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein modification by small protein conjugation or removal#GO:0070647;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;cellular process#GO:0009987;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 ubiquitin-protein ligase#PC00234 P53 pathway feedback loops 1#P04392>Pirh-2#G04684;P53 pathway feedback loops 1#P04392>Pirh-2#P04538 HUMAN|HGNC=12306|UniProtKB=Q14669 Q14669 TRIP12 PTHR45670:SF13 E3 UBIQUITIN-PROTEIN LIGASE TRIP12 E3 UBIQUITIN-PROTEIN LIGASE TRIP12 catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842 cellular process#GO:0009987;response to stress#GO:0006950;post-translational protein modification#GO:0043687;proteasomal protein catabolic process#GO:0010498;protein ubiquitination#GO:0016567;DNA damage response#GO:0006974;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;cellular response to stimulus#GO:0051716;protein polyubiquitination#GO:0000209;modification-dependent protein catabolic process#GO:0019941;protein modification by small protein conjugation#GO:0032446;protein modification process#GO:0036211;primary metabolic process#GO:0044238;catabolic process#GO:0009056;response to stimulus#GO:0050896;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=25653|UniProtKB=Q5JVF3 Q5JVF3 PCID2 PTHR12732:SF0 UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING PCI DOMAIN-CONTAINING PROTEIN 2 binding#GO:0005488;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;RNA binding#GO:0003723;DNA binding#GO:0003677 nucleic acid transport#GO:0050657;localization#GO:0051179;nuclear export#GO:0051168;nuclear transport#GO:0051169;nucleocytoplasmic transport#GO:0006913;RNA localization#GO:0006403;RNA transport#GO:0050658;transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery#GO:0000972;nucleobase-containing compound transport#GO:0015931;DNA-templated transcription#GO:0006351;mRNA transport#GO:0051028;RNA biosynthetic process#GO:0032774;establishment of RNA localization#GO:0051236;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;poly(A)+ mRNA export from nucleus#GO:0016973;chromosome organization#GO:0051276;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;transport#GO:0006810;transcription by RNA polymerase II#GO:0006366;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;nitrogen compound transport#GO:0071705;macromolecule localization#GO:0033036;macromolecule biosynthetic process#GO:0009059;post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery#GO:0000973;cellular localization#GO:0051641;RNA metabolic process#GO:0016070;mRNA export from nucleus#GO:0006406;nucleic acid biosynthetic process#GO:0141187;cellular component organization#GO:0016043;cellular component organization or biogenesis#GO:0071840;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;gene expression#GO:0010467;transcription elongation by RNA polymerase II#GO:0006368;DNA-templated transcription elongation#GO:0006354;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of localization in cell#GO:0051649 organelle#GO:0043226;cellular anatomical structure#GO:0110165;transcription export complex 2#GO:0070390;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=11138|UniProtKB=P37840 P37840 SNCA PTHR13820:SF5 SYNUCLEIN ALPHA-SYNUCLEIN transition metal ion binding#GO:0046914;copper ion binding#GO:0005507;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;cation binding#GO:0043169;metal ion binding#GO:0046872 trans-synaptic signaling#GO:0099537;organelle localization#GO:0051640;signal release#GO:0023061;synapse organization#GO:0050808;secretion#GO:0046903;localization#GO:0051179;cell communication#GO:0007154;signal release from synapse#GO:0099643;chemical synaptic transmission#GO:0007268;synaptic vesicle endocytosis#GO:0048488;cell junction organization#GO:0034330;anterograde trans-synaptic signaling#GO:0098916;transport#GO:0006810;synaptic vesicle cycle#GO:0099504;establishment of localization#GO:0051234;vesicle localization#GO:0051648;synaptic vesicle recycling#GO:0036465;neurotransmitter secretion#GO:0007269;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;cellular localization#GO:0051641;secretion by cell#GO:0032940;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;protein-containing complex assembly#GO:0065003;establishment of organelle localization#GO:0051656;endocytosis#GO:0006897;signaling#GO:0023052;export from cell#GO:0140352;regulated exocytosis#GO:0045055;exocytic process#GO:0140029;vesicle-mediated transport in synapse#GO:0099003;import into cell#GO:0098657;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;exocytosis#GO:0006887;synaptic signaling#GO:0099536;synaptic vesicle transport#GO:0048489;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;synaptic vesicle exocytosis#GO:0016079;establishment of localization in cell#GO:0051649;synaptic vesicle localization#GO:0097479;vesicle-mediated transport#GO:0016192;cellular component assembly#GO:0022607;establishment of vesicle localization#GO:0051650;neurotransmitter transport#GO:0006836 axon#GO:0030424;intracellular anatomical structure#GO:0005622;cell body#GO:0044297;synapse#GO:0045202;cellular anatomical structure#GO:0110165;distal axon#GO:0150034;plasma membrane bounded cell projection#GO:0120025;neuronal cell body#GO:0043025;neuron projection terminus#GO:0044306;cell projection#GO:0042995;cell junction#GO:0030054;axon terminus#GO:0043679;neuron projection#GO:0043005;presynapse#GO:0098793;cytoplasm#GO:0005737;somatodendritic compartment#GO:0036477 membrane traffic protein#PC00150;membrane trafficking regulatory protein#PC00151 Parkinson disease#P00049>alpha-Synuclein#P01218 HUMAN|HGNC=10499|UniProtKB=P06702 P06702 S100A9 PTHR11639:SF79 S100 CALCIUM-BINDING PROTEIN PROTEIN S100-A9 cation binding#GO:0043169;metal ion binding#GO:0046872;protein binding#GO:0005515;calcium ion binding#GO:0005509;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167 taxis#GO:0042330;response to chemical#GO:0042221;neutrophil migration#GO:1990266;defense response to other organism#GO:0098542;granulocyte migration#GO:0097530;nervous system development#GO:0007399;response to biotic stimulus#GO:0009607;cell-cell adhesion#GO:0098609;response to stress#GO:0006950;defense response to symbiont#GO:0140546;leukocyte cell-cell adhesion#GO:0007159;cellular process#GO:0009987;multicellular organism development#GO:0007275;gliogenesis#GO:0042063;neutrophil chemotaxis#GO:0030593;antimicrobial humoral response#GO:0019730;humoral immune response#GO:0006959;central nervous system development#GO:0007417;granulocyte chemotaxis#GO:0071621;cell differentiation#GO:0030154;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052;cell development#GO:0048468;regulation of biological process#GO:0050789;cellular response to chemical stimulus#GO:0070887;immune system process#GO:0002376;animal gross anatomical part developmental process#GO:0160108;cell adhesion#GO:0007155;endothelial cell migration#GO:0043542;glial cell differentiation#GO:0010001;cell migration#GO:0016477;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;response to other organism#GO:0051707;immune response#GO:0006955;cellular developmental process#GO:0048869;response to external stimulus#GO:0009605;myeloid leukocyte migration#GO:0097529;neurogenesis#GO:0022008;defense response#GO:0006952;leukocyte chemotaxis#GO:0030595;leukocyte migration#GO:0050900;developmental process#GO:0032502;cell motility#GO:0048870;response to external biotic stimulus#GO:0043207;locomotion#GO:0040011;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;anatomical structure development#GO:0048856;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;cell chemotaxis#GO:0060326;system development#GO:0048731;inflammatory response#GO:0006954;chemotaxis#GO:0006935 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 calmodulin-related#PC00061;calcium-binding protein#PC00060 HUMAN|HGNC=4962|UniProtKB=P13747 P13747 HLA-E PTHR16675:SF164 MHC CLASS I-RELATED HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, ALPHA CHAIN E signaling receptor binding#GO:0005102;binding#GO:0005488;peptide binding#GO:0042277;antigen binding#GO:0003823;protein binding#GO:0005515 regulation of leukocyte mediated immunity#GO:0002703;regulation of biological process#GO:0050789;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;positive regulation of adaptive immune response#GO:0002821;response to stimulus#GO:0050896;regulation of lymphocyte mediated immunity#GO:0002706;immune system process#GO:0002376;regulation of cell killing#GO:0031341;regulation of immune response#GO:0050776;antigen processing and presentation#GO:0019882;regulation of immune effector process#GO:0002697;positive regulation of lymphocyte mediated immunity#GO:0002708;regulation of leukocyte mediated cytotoxicity#GO:0001910;positive regulation of immune system process#GO:0002684;positive regulation of biological process#GO:0048518;immune response#GO:0006955;positive regulation of cellular process#GO:0048522;positive regulation of response to stimulus#GO:0048584;positive regulation of immune effector process#GO:0002699;biological regulation#GO:0065007;positive regulation of leukocyte mediated immunity#GO:0002705;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778 membrane#GO:0016020;cell periphery#GO:0071944;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;extracellular region#GO:0005576;external side of plasma membrane#GO:0009897;side of membrane#GO:0098552 defense/immunity protein#PC00090;major histocompatibility complex protein#PC00149 HUMAN|HGNC=24826|UniProtKB=A0A804HLA8 A0A804HLA8 GNG5B PTHR13809:SF5 GUANINE NUCLEOTIDE-BINDING PROTEIN GAMMA SUBUNIT GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)_G(S)_G(O) SUBUNIT GAMMA-5-RELATED GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity#GO:0016787;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817;molecular function regulator activity#GO:0098772;ribonucleoside triphosphate phosphatase activity#GO:0017111 biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 extrinsic component of plasma membrane#GO:0019897;side of membrane#GO:0098552;extrinsic component of membrane#GO:0019898;extrinsic component of cytoplasmic side of plasma membrane#GO:0031234;cytoplasmic side of membrane#GO:0098562;catalytic complex#GO:1902494;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane#GO:0016020;cytoplasmic side of plasma membrane#GO:0009898;membrane protein complex#GO:0098796 heterotrimeric G-protein#PC00117 Beta2 adrenergic receptor signaling pathway#P04378>G-Protein#P04443;Histamine H2 receptor mediated signaling pathway#P04386>G-Protein#P04490;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Ggamma#P00721;GABA-B receptor II signaling#P05731>Ggamma#P05754;5HT1 type receptor mediated signaling pathway#P04373>G-protein#P04408;Histamine H1 receptor mediated signaling pathway#P04385>G-Protein#P04488;Opioid proenkephalin pathway#P05915>G-protein#P05994;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Ggamma#P00726;Metabotropic glutamate receptor group II pathway#P00040>G-protein#P01047;Beta1 adrenergic receptor signaling pathway#P04377>G-Protein#P04436;Opioid prodynorphin pathway#P05916>G-protein#P06002;Beta3 adrenergic receptor signaling pathway#P04379>G-Protein#P04448;Endogenous cannabinoid signaling#P05730>Ggamma#P05744;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GIRK#P00743;Wnt signaling pathway#P00057>Ggamma#P01465;Opioid proopiomelanocortin pathway#P05917>G-protein#P06012;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>G-Protein#P01073;Metabotropic glutamate receptor group III pathway#P00039>G-Protein#P01045;5HT4 type receptor mediated signaling pathway#P04376>G-protein#P04430;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>G-Protein#P01085;Cortocotropin releasing factor receptor signaling pathway#P04380>G-Protein#P04458;Oxytocin receptor mediated signaling pathway#P04391>G-Protein#P04534;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Ggamma#P00751;5HT2 type receptor mediated signaling pathway#P04374>G-protein#P04416;Thyrotropin-releasing hormone receptor signaling pathway#P04394>G-Protein#P04584;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Gbetagamma#P00836;Enkephalin release#P05913>G-Protein (s)#P05977;Enkephalin release#P05913>G-Protein (i)#P05974 HUMAN|HGNC=4664|UniProtKB=Q12789 Q12789 GTF3C1 PTHR15180:SF1 GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1 GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1 gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;rRNA transcription#GO:0009303;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;transcription initiation at RNA polymerase III promoter#GO:0006384;DNA-templated transcription initiation#GO:0006352;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;transcription by RNA polymerase III#GO:0006383;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;transcription factor TFIIIC complex#GO:0000127;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 general transcription factor#PC00259;RNA metabolism protein#PC00031 HUMAN|HGNC=8761|UniProtKB=Q9BUL8 Q9BUL8 PDCD10 PTHR13250:SF1 TF-1 CELL APOPTOSIS RELATED PROTEIN-15 PROGRAMMED CELL DEATH PROTEIN 10 protein binding#GO:0005515;binding#GO:0005488;kinase binding#GO:0019900;enzyme binding#GO:0019899;protein kinase binding#GO:0019901 cellular component organization or biogenesis#GO:0071840;endomembrane system organization#GO:0010256;cellular component assembly#GO:0022607;Golgi organization#GO:0007030;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular component organization#GO:0016043 protein-containing complex#GO:0032991 HUMAN|HGNC=12633|UniProtKB=O00507 O00507 USP9Y PTHR24006:SF693 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 9Y hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;catalytic activity#GO:0003824;cysteine-type deubiquitinase activity#GO:0004843;cysteine-type peptidase activity#GO:0008234 regulation of protein stability#GO:0031647;cellular process#GO:0009987;cell migration#GO:0016477;cell motility#GO:0048870;biological regulation#GO:0065007;regulation of biological quality#GO:0065008 nucleus#GO:0005634;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 protease#PC00190;cysteine protease#PC00081 HUMAN|HGNC=16863|UniProtKB=Q9NYF8 Q9NYF8 BCLAF1 PTHR15268:SF4 THRAP3/BCLAF1 BCL-2-ASSOCIATED TRANSCRIPTION FACTOR 1 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA binding#GO:0003677 positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;mediator complex#GO:0016592;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513 DNA metabolism protein#PC00009 HUMAN|HGNC=21498|UniProtKB=Q676U5 Q676U5 ATG16L1 PTHR19878:SF6 AUTOPHAGY PROTEIN 16-LIKE AUTOPHAGY-RELATED PROTEIN 16-1 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;protein-membrane adaptor activity#GO:0043495 organelle assembly#GO:0070925;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;vacuole organization#GO:0007033;autophagosome assembly#GO:0000045;process utilizing autophagic mechanism#GO:0061919;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;autophagy#GO:0006914;cellular process#GO:0009987;autophagosome organization#GO:1905037;cellular component assembly#GO:0022607;catabolic process#GO:0009056;macroautophagy#GO:0016236 vacuole#GO:0005773;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;membrane#GO:0016020;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;vacuolar membrane#GO:0005774;transferase complex#GO:1990234;phagophore assembly site#GO:0000407;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;autophagosome membrane#GO:0000421;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;autophagosome#GO:0005776 HUMAN|HGNC=8173|UniProtKB=O60403 O60403 OR10H2 PTHR26453:SF712 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 10H1-RELATED transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception#GO:0007600;nervous system process#GO:0050877;response to stimulus#GO:0050896;response to chemical#GO:0042221;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;detection of chemical stimulus#GO:0009593 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=15663|UniProtKB=Q9NYU2 Q9NYU2 UGGT1 PTHR11226:SF3 UDP-GLUCOSE GLYCOPROTEIN:GLUCOSYLTRANSFERASE UDP-GLUCOSE:GLYCOPROTEIN GLUCOSYLTRANSFERASE 1 glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194;glucosyltransferase activity#GO:0046527;transferase activity#GO:0016740;catalytic activity#GO:0003824;UDP-glucosyltransferase activity#GO:0035251;hexosyltransferase activity#GO:0016758 biosynthetic process#GO:0009058;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 glycosyltransferase#PC00111 HUMAN|HGNC=29619|UniProtKB=Q2M385 Q2M385 MPEG1 PTHR31463:SF4 MACROPHAGE-EXPRESSED GENE 1 PROTEIN MACROPHAGE-EXPRESSED GENE 1 PROTEIN response to external stimulus#GO:0009605;defense response#GO:0006952;defense response to bacterium#GO:0042742;response to bacterium#GO:0009617;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to other organism#GO:0051707;response to stimulus#GO:0050896;response to biotic stimulus#GO:0009607;response to stress#GO:0006950 HUMAN|HGNC=11486|UniProtKB=P51809 P51809 VAMP7 PTHR21136:SF196 SNARE PROTEINS VESICLE-ASSOCIATED MEMBRANE PROTEIN 7 binding#GO:0005488;SNARE binding#GO:0000149;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;protein binding#GO:0005515;SNAP receptor activity#GO:0005484 Golgi organization#GO:0007030;protein localization to plasma membrane#GO:0072659;vesicle fusion#GO:0006906;microtubule-based movement#GO:0007018;catabolic process#GO:0009056;Golgi to plasma membrane transport#GO:0006893;localization within membrane#GO:0051668;establishment of protein localization to plasma membrane#GO:0061951;organelle localization#GO:0051640;endosome to lysosome transport#GO:0008333;secretion#GO:0046903;localization#GO:0051179;vesicle localization#GO:0051648;macromolecule localization#GO:0033036;membrane fusion#GO:0061025;membrane organization#GO:0061024;cytoskeleton-dependent intracellular transport#GO:0030705;transport#GO:0006810;vacuolar transport#GO:0007034;intracellular transport#GO:0046907;phagocytosis#GO:0006909;vesicle transport along microtubule#GO:0047496;vesicle-mediated transport to the plasma membrane#GO:0098876;intracellular protein localization#GO:0008104;vesicle cytoskeletal trafficking#GO:0099518;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;cellular component organization#GO:0016043;protein localization to membrane#GO:0072657;Golgi to plasma membrane protein transport#GO:0043001;export from cell#GO:0140352;endocytosis#GO:0006897;establishment of organelle localization#GO:0051656;microtubule-based transport#GO:0099111;lysosomal transport#GO:0007041;protein transport#GO:0015031;process utilizing autophagic mechanism#GO:0061919;secretion by cell#GO:0032940;post-Golgi vesicle-mediated transport#GO:0006892;cellular localization#GO:0051641;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;autophagy#GO:0006914;establishment of protein localization#GO:0045184;establishment of protein localization to membrane#GO:0090150;organelle organization#GO:0006996;organelle membrane fusion#GO:0090174;organelle transport along microtubule#GO:0072384;endomembrane system organization#GO:0010256;establishment of vesicle localization#GO:0051650;vesicle-mediated transport#GO:0016192;organelle fusion#GO:0048284;Golgi vesicle transport#GO:0048193;membrane invagination#GO:0010324;protein localization to cell periphery#GO:1990778;metabolic process#GO:0008152;vesicle organization#GO:0016050;microtubule-based process#GO:0007017;exocytosis#GO:0006887;import into cell#GO:0098657;cellular component organization or biogenesis#GO:0071840;phagocytosis, engulfment#GO:0006911 cytoplasm#GO:0005737;plasma membrane#GO:0005886;vacuole#GO:0005773;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cell periphery#GO:0071944;lysosomal membrane#GO:0005765;membrane#GO:0016020;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;vacuolar membrane#GO:0005774;lytic vacuole#GO:0000323;Golgi apparatus#GO:0005794;intracellular membrane-bounded organelle#GO:0043231;SNARE complex#GO:0031201;cellular anatomical structure#GO:0110165;organelle#GO:0043226;lysosome#GO:0005764;vesicle#GO:0031982;lytic vacuole membrane#GO:0098852;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;intracellular organelle#GO:0043229 SNARE protein#PC00034;membrane traffic protein#PC00150 HUMAN|HGNC=33771|UniProtKB=P0DUD1 P0DUD1 SPDYE8 PTHR31156:SF15 WBSCR19-LIKE PROTEIN SPEEDY PROTEIN E10-RELATED HUMAN|HGNC=13611|UniProtKB=Q9NXK8 Q9NXK8 FBXL12 PTHR16134:SF153 F-BOX/TPR REPEAT PROTEIN POF3 F-BOX_LRR-REPEAT PROTEIN 12 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;enzyme-substrate adaptor activity#GO:0140767;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163 ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535;SCF ubiquitin ligase complex#GO:0019005;transferase complex#GO:1990234;catalytic complex#GO:1902494 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=15932|UniProtKB=O95925 O95925 EPPIN PTHR46751:SF2 EPPIN EPPIN regulation of cell motility#GO:2000145;negative regulation of cellular process#GO:0048523;regulation of microtubule-based process#GO:0032886;regulation of locomotion#GO:0040012;negative regulation of locomotion#GO:0040013;negative regulation of cell motility#GO:2000146;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of microtubule-based movement#GO:0060632;regulation of reproductive process#GO:2000241;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=16255|UniProtKB=O95932 O95932 TGM6 PTHR11590:SF50 PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE 6 transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 skin development#GO:0043588;cell differentiation#GO:0030154;epithelium development#GO:0060429;tissue development#GO:0009888;epidermal cell differentiation#GO:0009913;epithelial cell differentiation#GO:0030855;cellular process#GO:0009987;cellular developmental process#GO:0048869;animal organ development#GO:0048513;anatomical structure development#GO:0048856;developmental process#GO:0032502;animal gross anatomical part developmental process#GO:0160108;epidermis development#GO:0008544;keratinocyte differentiation#GO:0030216 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 transferase#PC00220 HUMAN|HGNC=18864|UniProtKB=Q96L42 Q96L42 KCNH8 PTHR10217:SF380 VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL VOLTAGE-GATED DELAYED RECTIFIER POTASSIUM CHANNEL KCNH8 transporter activity#GO:0005215;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261;potassium channel activity#GO:0005267;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079 regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;transport#GO:0006810;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;biological regulation#GO:0065007;metal ion transport#GO:0030001;potassium ion transmembrane transport#GO:0071805;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=16181|UniProtKB=Q8TEL6 Q8TEL6 TRPC4AP PTHR31743:SF1 TRANSIENT RECEPTOR POTENTIAL CHANNEL 4-ASSOCIATED PROTEIN TCPC4AP SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 4-ASSOCIATED PROTEIN protein binding#GO:0005515;binding#GO:0005488;phosphatase binding#GO:0019902;enzyme binding#GO:0019899 catabolic process#GO:0009056;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163 intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;Cul4-RING E3 ubiquitin ligase complex#GO:0080008;catalytic complex#GO:1902494;transferase complex#GO:1990234 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=12404|UniProtKB=P49638 P49638 TTPA PTHR10174:SF225 ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED ALPHA-TOCOPHEROL TRANSFER PROTEIN small molecule binding#GO:0036094;binding#GO:0005488;anion binding#GO:0043168;ion binding#GO:0043167;lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104;lipid transfer activity#GO:0120013;phosphatidylinositol bisphosphate binding#GO:1902936;transporter activity#GO:0005215;heterocyclic compound binding#GO:1901363 transport#GO:0006810;cellular process#GO:0009987;metabolic process#GO:0008152;vitamin E metabolic process#GO:0042360;vitamin transport#GO:0051180;establishment of localization#GO:0051234;localization#GO:0051179 intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;vesicle#GO:0031982;intracellular vesicle#GO:0097708;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;late endosome#GO:0005770;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 transfer/carrier protein#PC00219 HUMAN|HGNC=465|UniProtKB=Q16671 Q16671 AMHR2 PTHR23255:SF49 TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II ANTI-MUELLERIAN HORMONE TYPE-2 RECEPTOR catalytic activity, acting on a protein#GO:0140096;transmembrane receptor protein kinase activity#GO:0019199;signaling receptor activity#GO:0038023;transferase activity#GO:0016740;catalytic activity#GO:0003824;transforming growth factor beta receptor activity#GO:0005024;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;molecular transducer activity#GO:0060089;transmembrane receptor protein serine/threonine kinase activity#GO:0004675;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;transmembrane signaling receptor activity#GO:0004888 regulation of cellular process#GO:0050794;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;response to growth factor#GO:0070848;signaling#GO:0023052;response to endogenous stimulus#GO:0009719;cellular response to stimulus#GO:0051716;BMP signaling pathway#GO:0030509;regulation of biological process#GO:0050789;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cellular response to growth factor stimulus#GO:0071363;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;cell surface receptor signaling pathway#GO:0007166;cellular response to BMP stimulus#GO:0071773;response to BMP#GO:0071772 plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;signaling receptor complex#GO:0043235;cell periphery#GO:0071944;membrane#GO:0016020 serine/threonine protein kinase receptor#PC00205 TGF-beta signaling pathway#P00052>TGFbetareceptor II#P01277;TGF-beta signaling pathway#P00052>TGFbetareceptors#P01283;Gonadotropin-releasing hormone receptor pathway#P06664>MISRII#P06792 HUMAN|HGNC=28982|UniProtKB=Q12766 Q12766 HMGXB3 PTHR17609:SF2 HMG DOMAIN-CONTAINING PROTEIN 3 HMG DOMAIN-CONTAINING PROTEIN 3 HMG box transcription factor#PC00024;DNA-binding transcription factor#PC00218 HUMAN|HGNC=25846|UniProtKB=Q53H96 Q53H96 PYCR3 PTHR11645:SF72 PYRROLINE-5-CARBOXYLATE REDUCTASE PYRROLINE-5-CARBOXYLATE REDUCTASE 3 oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 amino acid biosynthetic process#GO:0008652;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;small molecule biosynthetic process#GO:0044283;proteinogenic amino acid biosynthetic process#GO:0170038;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;cellular process#GO:0009987;carboxylic acid biosynthetic process#GO:0046394;proteinogenic amino acid metabolic process#GO:0170039;small molecule metabolic process#GO:0044281;amino acid metabolic process#GO:0006520;biosynthetic process#GO:0009058 metabolite interconversion enzyme#PC00262;reductase#PC00198 Proline biosynthesis#P02768>Pyrroline-5-carboxylate reductase#P03113 HUMAN|HGNC=10626|UniProtKB=Q9Y4X3 Q9Y4X3 CCL27 PTHR12015:SF208 SMALL INDUCIBLE CYTOKINE A C-C MOTIF CHEMOKINE 27 cytokine#PC00083 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CHK#P00856 HUMAN|HGNC=14264|UniProtKB=Q9NY12 Q9NY12 GAR1 PTHR23237:SF10 NUCLEOLAR PROTEIN FAMILY A MEMBER 1 SNORNP PROTEIN GAR1 H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 1 binding#GO:0005488;nucleic acid binding#GO:0003676;snoRNA binding#GO:0030515;RNA binding#GO:0003723 RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;RNA metabolic process#GO:0016070;rRNA modification#GO:0000154;cellular component organization#GO:0016043;ribonucleoprotein complex biogenesis#GO:0022613;DNA metabolic process#GO:0006259;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;DNA biosynthetic process#GO:0071897;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;RNA processing#GO:0006396;telomere maintenance via telomere lengthening#GO:0010833;telomere maintenance via telomerase#GO:0007004;gene expression#GO:0010467;rRNA processing#GO:0006364;telomere organization#GO:0032200;macromolecule modification#GO:0043412;pseudouridine synthesis#GO:0001522;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;rRNA metabolic process#GO:0016072;RNA-templated DNA biosynthetic process#GO:0006278;chromosome organization#GO:0051276;telomere maintenance#GO:0000723;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139 sno(s)RNA-containing ribonucleoprotein complex#GO:0005732;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;nucleolus#GO:0005730;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 RNA metabolism protein#PC00031 HUMAN|HGNC=3183|UniProtKB=Q8IXK0 Q8IXK0 PHC2 PTHR12247:SF86 POLYCOMB GROUP PROTEIN POLYHOMEOTIC-LIKE PROTEIN 2 protein binding#GO:0005515;binding#GO:0005488;histone binding#GO:0042393;chromatin binding#GO:0003682 biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523;negative regulation of metabolic process#GO:0009892;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892 nuclear protein-containing complex#GO:0140513;PRC1 complex#GO:0035102;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;protein-containing complex#GO:0032991;PcG protein complex#GO:0031519;nucleus#GO:0005634;ubiquitin ligase complex#GO:0000151;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;nuclear ubiquitin ligase complex#GO:0000152;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=17731|UniProtKB=Q8N2M8 Q8N2M8 CLASRP PTHR13161:SF4 SPLICING FACTOR SUPPRESSOR OF WHITE APRICOT CLK4-ASSOCIATING SERINE_ARGININE RICH PROTEIN RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;macromolecule metabolic process#GO:0043170;alternative mRNA splicing, via spliceosome#GO:0000380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 RNA metabolism protein#PC00031;RNA splicing factor#PC00148;RNA processing factor#PC00147 HUMAN|HGNC=19719|UniProtKB=Q9HBX8 Q9HBX8 LGR6 PTHR45836:SF19 SLIT HOMOLOG LEUCINE-RICH REPEAT-CONTAINING G PROTEIN-COUPLED RECEPTOR 6 glycosaminoglycan binding#GO:0005539;carbohydrate derivative binding#GO:0097367;signaling receptor binding#GO:0005102;binding#GO:0005488;heparin binding#GO:0008201;protein binding#GO:0005515 multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;axon guidance#GO:0007411;axon development#GO:0061564;cellular developmental process#GO:0048869;neuron projection guidance#GO:0097485;response to external stimulus#GO:0009605;neurogenesis#GO:0022008;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;locomotion#GO:0040011;anatomical structure development#GO:0048856;system development#GO:0048731;chemotaxis#GO:0006935;response to chemical#GO:0042221;taxis#GO:0042330;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;neuron projection development#GO:0031175;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cell projection morphogenesis#GO:0048858;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell differentiation#GO:0030154;response to stimulus#GO:0050896;cell projection organization#GO:0030030;cell morphogenesis#GO:0000902;cell development#GO:0048468;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;axonogenesis#GO:0007409;neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699 HUMAN|HGNC=22952|UniProtKB=Q8N2C3 Q8N2C3 DEPDC4 PTHR16206:SF10 DEP DOMAIN-CONTAINING DEP DOMAIN-CONTAINING PROTEIN 4 scaffold/adaptor protein#PC00226 HUMAN|HGNC=33279|UniProtKB=P0C7T5 P0C7T5 ATXN1L PTHR13392:SF6 ATAXIN 1 ATAXIN-1-LIKE RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;chromatin binding#GO:0003682 negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;central nervous system development#GO:0007417;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;animal gross anatomical part developmental process#GO:0160108;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of macromolecule biosynthetic process#GO:0010558;nervous system development#GO:0007399;head development#GO:0060322;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;animal organ development#GO:0048513;multicellular organism development#GO:0007275;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;system development#GO:0048731;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;multicellular organismal process#GO:0032501;brain development#GO:0007420;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=17168|UniProtKB=Q9H2M9 Q9H2M9 RAB3GAP2 PTHR12472:SF1 RAB3-GAP REGULATORY DOMAIN RAB3 GTPASE-ACTIVATING PROTEIN NON-CATALYTIC SUBUNIT enzyme binding#GO:0019899;binding#GO:0005488;molecular function regulator activity#GO:0098772;protein binding#GO:0005515;enzyme regulator activity#GO:0030234;small GTPase binding#GO:0031267 regulation of biological process#GO:0050789;catabolic process#GO:0009056;signaling#GO:0023052;localization within membrane#GO:0051668;cell communication#GO:0007154;localization#GO:0051179;cellular localization#GO:0051641;process utilizing autophagic mechanism#GO:0061919;establishment of protein localization to membrane#GO:0090150;synaptic signaling#GO:0099536;establishment of protein localization#GO:0045184;autophagy#GO:0006914;cellular process#GO:0009987;establishment of protein localization to endoplasmic reticulum#GO:0072599;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;macroautophagy#GO:0016236;metabolic process#GO:0008152;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234 synaptic membrane#GO:0097060;cell junction#GO:0030054;cell periphery#GO:0071944;presynapse#GO:0098793;membrane#GO:0016020;cytoplasm#GO:0005737;presynaptic membrane#GO:0042734;vacuole#GO:0005773;plasma membrane#GO:0005886;plasma membrane region#GO:0098590;intracellular organelle#GO:0043229;autophagosome#GO:0005776;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226 G-protein modulator#PC00022 HUMAN|HGNC=5030|UniProtKB=Q13151 Q13151 HNRNPA0 PTHR48024:SF71 GEO13361P1-RELATED HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A0 mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 RNA stabilization#GO:0043489;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of biological quality#GO:0065008;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;regulation of biological process#GO:0050789;regulation of mRNA stability#GO:0043488;negative regulation of metabolic process#GO:0009892;negative regulation of RNA metabolic process#GO:0051253;regulation of mRNA metabolic process#GO:1903311;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604;mRNA stabilization#GO:0048255;regulation of RNA stability#GO:0043487;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;negative regulation of catabolic process#GO:0009895;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;negative regulation of RNA catabolic process#GO:1902369;regulation of biosynthetic process#GO:0009889;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;positive regulation of gene expression#GO:0010628;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=24741|UniProtKB=Q8NAN2 Q8NAN2 MIGA1 PTHR21508:SF3 MITOGUARDIN MITOGUARDIN 1 mitochondrion organization#GO:0007005;cellular component organization or biogenesis#GO:0071840;organelle fusion#GO:0048284;cellular process#GO:0009987;organelle organization#GO:0006996;mitochondrial fusion#GO:0008053;cellular component organization#GO:0016043 HUMAN|HGNC=11736|UniProtKB=Q9BXU2 Q9BXU2 TEX13B PTHR23111:SF94 ZINC FINGER PROTEIN TESTIS-EXPRESSED PROTEIN 13B mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 HUMAN|HGNC=4478|UniProtKB=Q99677 Q99677 LPAR4 PTHR24232:SF41 G-PROTEIN COUPLED RECEPTOR LYSOPHOSPHATIDIC ACID RECEPTOR 4 G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;bioactive lipid receptor activity#GO:0045125;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=13091|UniProtKB=Q96RE9 Q96RE9 ZNF300 PTHR24377:SF1051 IP01015P-RELATED ZINC FINGER PROTEIN 300 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=29580|UniProtKB=Q8WWF3 Q8WWF3 SSMEM1 PTHR31822:SF1 SERINE-RICH SINGLE-PASS MEMBRANE PROTEIN 1 SERINE-RICH SINGLE-PASS MEMBRANE PROTEIN 1 HUMAN|HGNC=25638|UniProtKB=Q96EY4 Q96EY4 TMA16 PTHR13349:SF2 TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16 TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 cellular component organization or biogenesis#GO:0071840;ribonucleoprotein complex biogenesis#GO:0022613;ribosome biogenesis#GO:0042254;ribosomal large subunit biogenesis#GO:0042273;cellular component biogenesis#GO:0044085;cellular process#GO:0009987 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=710|UniProtKB=P36575 P36575 ARR3 PTHR11792:SF19 ARRESTIN ARRESTIN-C protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102;G protein-coupled receptor binding#GO:0001664 regulation of biological process#GO:0050789;negative regulation of G protein-coupled receptor signaling pathway#GO:0045744;negative regulation of biological process#GO:0048519;regulation of cell communication#GO:0010646;endocytosis#GO:0006897;regulation of cellular process#GO:0050794;nervous system process#GO:0050877;regulation of signaling#GO:0023051;sensory perception#GO:0007600;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648;localization#GO:0051179;cellular process#GO:0009987;receptor internalization#GO:0031623;negative regulation of signal transduction#GO:0009968;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;vesicle-mediated transport#GO:0016192;negative regulation of response to stimulus#GO:0048585;multicellular organismal process#GO:0032501;regulation of response to stimulus#GO:0048583;transport#GO:0006810;regulation of G protein-coupled receptor signaling pathway#GO:0008277;negative regulation of cellular process#GO:0048523;system process#GO:0003008;receptor-mediated endocytosis#GO:0006898;import into cell#GO:0098657;establishment of localization#GO:0051234 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 scaffold/adaptor protein#PC00226 Wnt signaling pathway#P00057>beta-arrestin#P01456 HUMAN|HGNC=30880|UniProtKB=Q9NZ45 Q9NZ45 CISD1 PTHR13680:SF42 CDGSH IRON-SULFUR DOMAIN-CONTAINING PROTEIN 1 CDGSH IRON-SULFUR DOMAIN-CONTAINING PROTEIN 1 iron-sulfur cluster binding#GO:0051536;transaminase activity#GO:0008483;transferase activity#GO:0016740;binding#GO:0005488;small molecule binding#GO:0036094;catalytic activity#GO:0003824 intracellular iron ion homeostasis#GO:0006879;homeostatic process#GO:0042592;intracellular monoatomic ion homeostasis#GO:0006873;monoatomic ion homeostasis#GO:0050801;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;intracellular monoatomic cation homeostasis#GO:0030003;inorganic ion homeostasis#GO:0098771;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;organelle envelope#GO:0031967;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;outer membrane#GO:0019867;cytoplasm#GO:0005737;organelle outer membrane#GO:0031968;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;membrane#GO:0016020;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;mitochondrial outer membrane#GO:0005741 HUMAN|HGNC=487|UniProtKB=Q9Y264 Q9Y264 ANGPT4 PTHR19143:SF31 FIBRINOGEN/TENASCIN/ANGIOPOEITIN ANGIOPOIETIN-4 protein tyrosine kinase binding#GO:1990782;binding#GO:0005488;kinase binding#GO:0019900;signaling receptor binding#GO:0005102;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;protein binding#GO:0005515;receptor tyrosine kinase binding#GO:0030971 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154 external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HUMAN|HGNC=8527|UniProtKB=P55809 P55809 OXCT1 PTHR13707:SF30 KETOACID-COENZYME A TRANSFERASE SUCCINYL-COA:3-KETOACID COENZYME A TRANSFERASE 1, MITOCHONDRIAL transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring sulphur-containing groups#GO:0016782 mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;transferase#PC00220 HUMAN|HGNC=19706|UniProtKB=Q6UY14 Q6UY14 ADAMTSL4 PTHR13723:SF144 ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE ADAMTS-LIKE PROTEIN 4 catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222 primary metabolic process#GO:0044238;cellular component organization#GO:0016043;cellular process#GO:0009987;metabolic process#GO:0008152;proteolysis#GO:0006508;extracellular structure organization#GO:0043062;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;protein metabolic process#GO:0019538;extracellular matrix organization#GO:0030198;external encapsulating structure organization#GO:0045229 cellular anatomical structure#GO:0110165;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576 metalloprotease#PC00153 HUMAN|HGNC=14524|UniProtKB=O60271 O60271 SPAG9 PTHR13886:SF2 JNK/SAPK-ASSOCIATED PROTEIN C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 4 structural molecule activity#GO:0005198;MAP kinase scaffold activity#GO:0005078;cytoskeletal protein binding#GO:0008092;protein complex scaffold activity#GO:0140378;molecular adaptor activity#GO:0060090;signaling receptor complex adaptor activity#GO:0030159;protein binding#GO:0005515;signaling adaptor activity#GO:0035591;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;protein-macromolecule adaptor activity#GO:0030674;binding#GO:0005488;kinase binding#GO:0019900 localization#GO:0051179;vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;cellular process#GO:0009987;transport#GO:0006810 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HUMAN|HGNC=11923|UniProtKB=P28908 P28908 TNFRSF8 PTHR47497:SF1 TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 8 TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 8 transmembrane signal receptor#PC00197 HUMAN|HGNC=29485|UniProtKB=Q5VTA0 Q5VTA0 PRAMEF17 PTHR14224:SF2 SIMILAR TO PREFERENTIALLY EXPRESSED ANTIGEN IN MELANOMA-LIKE 3 PRAME FAMILY MEMBER 17 ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;ubiquitin ligase complex#GO:0000151;Cul2-RING ubiquitin ligase complex#GO:0031462;transferase complex#GO:1990234;catalytic complex#GO:1902494;cytoplasm#GO:0005737;cullin-RING ubiquitin ligase complex#GO:0031461;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 HUMAN|HGNC=8539|UniProtKB=P47900 P47900 P2RY1 PTHR24231:SF2 PURINOCEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR P2Y PURINOCEPTOR 1 G protein-coupled receptor activity#GO:0004930;nucleotide binding#GO:0000166;molecular transducer activity#GO:0060089;small molecule binding#GO:0036094;anion binding#GO:0043168;signaling receptor binding#GO:0005102;ion binding#GO:0043167;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;signaling receptor activity#GO:0038023;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;G protein-coupled receptor binding#GO:0001664;protein binding#GO:0005515;binding#GO:0005488;ATP binding#GO:0005524;nucleoside phosphate binding#GO:1901265;transmembrane signaling receptor activity#GO:0004888 biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;phospholipase C-activating G protein-coupled receptor signaling pathway#GO:0007200;G protein-coupled receptor signaling pathway#GO:0007186 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=6455|UniProtKB=O76014 O76014 KRT37 PTHR23239:SF110 INTERMEDIATE FILAMENT KERATIN, TYPE I CUTICULAR HA7 structural molecule activity#GO:0005198 cellular process#GO:0009987;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;tissue development#GO:0009888;epithelial cell differentiation#GO:0030855;epithelium development#GO:0060429;developmental process#GO:0032502;morphogenesis of an epithelium#GO:0002009;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;intermediate filament cytoskeleton organization#GO:0045104;cell differentiation#GO:0030154;intermediate filament organization#GO:0045109;animal gross anatomical part developmental process#GO:0160108;intermediate filament-based process#GO:0045103;supramolecular fiber organization#GO:0097435;anatomical structure development#GO:0048856;tissue morphogenesis#GO:0048729 intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;intermediate filament#GO:0005882;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228 intermediate filament#PC00129 HUMAN|HGNC=21637|UniProtKB=Q9UPW6 Q9UPW6 SATB2 PTHR15116:SF15 DNA-BINDING PROTEIN SATB FAMILY MEMBER DNA-BINDING PROTEIN SATB2 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987 cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;chromatin remodeling#GO:0006338;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;chromatin organization#GO:0006325;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 Lambda repressor-like transcription factor#PC00245;DNA-binding transcription factor#PC00218 HUMAN|HGNC=14844|UniProtKB=P0C617 P0C617 OR5AL1 PTHR48018:SF133 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5AL1 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;nervous system process#GO:0050877;sensory perception#GO:0007600;sensory perception of smell#GO:0007608;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=54397|UniProtKB=P0DTL4 P0DTL4 LY6S PTHR32217:SF3 LYMPHOCYTE ANTIGEN 6H LYMPHOCYTE ANTIGEN 6S signaling receptor regulator activity#GO:0030545;molecular function regulator activity#GO:0098772;acetylcholine receptor regulator activity#GO:0030548;signaling receptor binding#GO:0005102;acetylcholine receptor inhibitor activity#GO:0030550;binding#GO:0005488;neurotransmitter receptor regulator activity#GO:0099602;molecular function inhibitor activity#GO:0140678;signaling receptor inhibitor activity#GO:0030547;protein binding#GO:0005515 cellular response to nitrogen compound#GO:1901699;acetylcholine receptor signaling pathway#GO:0095500;response to chemical#GO:0042221;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;synaptic signaling#GO:0099536;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cell communication#GO:0007154;response to nitrogen compound#GO:1901698;cellular response to chemical stimulus#GO:0070887;response to oxygen-containing compound#GO:1901700 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HUMAN|HGNC=30557|UniProtKB=Q8WUT9 Q8WUT9 SLC25A43 PTHR24089:SF246 SOLUTE CARRIER FAMILY 25 SOLUTE CARRIER FAMILY 25 MEMBER 43 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739 secondary carrier transporter#PC00258;mitochondrial carrier protein#PC00158 HUMAN|HGNC=464|UniProtKB=P03971 P03971 AMH PTHR15009:SF4 MUELLERIAN-INHIBITING FACTOR ANTI-MUELLERIAN HORMONE protein binding#GO:0005515;signaling receptor binding#GO:0005102;cytokine receptor binding#GO:0005126;binding#GO:0005488 anatomical structure development#GO:0048856;system development#GO:0048731;reproductive system development#GO:0061458;animal gross anatomical part developmental process#GO:0160108;reproductive process#GO:0022414;reproductive structure development#GO:0048608;developmental process involved in reproduction#GO:0003006;anatomical structure morphogenesis#GO:0009653;multicellular organism development#GO:0007275;animal organ development#GO:0048513;development of primary male sexual characteristics#GO:0046546;developmental process#GO:0032502;development of primary sexual characteristics#GO:0045137;male sex differentiation#GO:0046661;multicellular organismal process#GO:0032501;gonad development#GO:0008406;sex differentiation#GO:0007548 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 Gonadotropin-releasing hormone receptor pathway#P06664>MIS#P06750 HUMAN|HGNC=10305|UniProtKB=P50914 P50914 RPL14 PTHR11127:SF4 60S RIBOSOMAL PROTEIN L14 LARGE RIBOSOMAL SUBUNIT PROTEIN EL14 structural constituent of ribosome#GO:0003735;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723;structural molecule activity#GO:0005198 cellular process#GO:0009987;ribosomal large subunit biogenesis#GO:0042273;cellular component biogenesis#GO:0044085;ribosome biogenesis#GO:0042254;ribonucleoprotein complex biogenesis#GO:0022613;cellular component organization or biogenesis#GO:0071840 intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;ribosome#GO:0005840;cytosol#GO:0005829;cytosolic large ribosomal subunit#GO:0022625;cytosolic ribosome#GO:0022626;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934 ribosomal protein#PC00202 HUMAN|HGNC=14862|UniProtKB=P0CAP2 P0CAP2 POLR2M PTHR23171:SF5 GDOWN1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT GRINL1A organelle localization#GO:0051640;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;cellular localization#GO:0051641;endoplasmic reticulum organization#GO:0007029;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;endomembrane system organization#GO:0010256 RNA polymerase complex#GO:0030880;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;protein-containing complex#GO:0032991;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;RNA polymerase II, core complex#GO:0005665;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;RNA polymerase II, holoenzyme#GO:0016591 DNA-directed RNA polymerase#PC00019;RNA metabolism protein#PC00031 HUMAN|HGNC=4916|UniProtKB=P54198 P54198 HIRA PTHR13831:SF0 MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS PROTEIN HIRA binding#GO:0005488;chromatin binding#GO:0003682;nucleosome binding#GO:0031491;protein-containing complex binding#GO:0044877 cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;chromatin organization#GO:0006325;chromatin remodeling#GO:0006338 intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;chromatin#GO:0000785;chromosome#GO:0005694;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=15809|UniProtKB=Q9Y3M9 Q9Y3M9 ZNF337 PTHR24381:SF22 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 337 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=30289|UniProtKB=Q9NYN1 Q9NYN1 RASL12 PTHR24070:SF252 RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY RAS-LIKE PROTEIN FAMILY MEMBER 12 hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides#GO:0016817 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;intracellular signaling cassette#GO:0141124;signaling#GO:0023052;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;establishment or maintenance of cell polarity#GO:0007163;Ras protein signal transduction#GO:0007265;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 small GTPase#PC00208 HUMAN|HGNC=20065|UniProtKB=Q70CQ3 Q70CQ3 USP30 PTHR24006:SF888 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30 deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;cysteine-type deubiquitinase activity#GO:0004843;cysteine-type peptidase activity#GO:0008234;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity, acting on a protein#GO:0140096 regulation of protein stability#GO:0031647;biological regulation#GO:0065007;regulation of biological quality#GO:0065008 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 protease#PC00190;cysteine protease#PC00081 HUMAN|HGNC=29190|UniProtKB=Q9UPQ9 Q9UPQ9 TNRC6B PTHR13020:SF32 TRINUCLEOTIDE REPEAT-CONTAINING GENE 6 TRINUCLEOTIDE REPEAT-CONTAINING GENE 6B PROTEIN post-transcriptional gene silencing#GO:0016441;regulatory ncRNA-mediated post-transcriptional gene silencing#GO:0035194;regulation of RNA metabolic process#GO:0051252;positive regulation of mRNA catabolic process#GO:0061014;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;regulatory ncRNA-mediated gene silencing#GO:0031047;regulation of biosynthetic process#GO:0009889;positive regulation of catabolic process#GO:0009896;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;positive regulation of metabolic process#GO:0009893;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;miRNA-mediated post-transcriptional gene silencing#GO:0035195;negative regulation of metabolic process#GO:0009892;positive regulation of mRNA metabolic process#GO:1903313;regulation of mRNA metabolic process#GO:1903311;negative regulation of macromolecule biosynthetic process#GO:0010558;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604 intracellular organelle#GO:0043229;P-body#GO:0000932;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;organelle#GO:0043226 RNA metabolism protein#PC00031 HUMAN|HGNC=23729|UniProtKB=Q8IYA7 Q8IYA7 MKX PTHR11211:SF3 IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX HOMEOBOX PROTEIN MOHAWK sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of biological process#GO:0050789;cell development#GO:0048468;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;muscle structure development#GO:0061061;animal gross anatomical part developmental process#GO:0160108;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;developmental process#GO:0032502;muscle organ development#GO:0007517;regulation of gene expression#GO:0010468;animal organ development#GO:0048513;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=23137|UniProtKB=Q8NC42 Q8NC42 RNF149 PTHR22765:SF39 RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING E3 UBIQUITIN-PROTEIN LIGASE RNF149 transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842 organelle#GO:0043226;late endosome#GO:0005770;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;endosome#GO:0005768;endoplasmic reticulum#GO:0005783 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=26814|UniProtKB=Q5EBL4 Q5EBL4 RILPL1 PTHR21502:SF6 ZINC FINGER PROTEIN DZIP1 RILP-LIKE PROTEIN 1 small GTPase binding#GO:0031267;protein binding#GO:0005515;enzyme binding#GO:0019899;binding#GO:0005488 organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031;cilium organization#GO:0044782;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component organization#GO:0016043;cilium assembly#GO:0060271;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;plasma membrane bounded cell projection organization#GO:0120036;cell projection organization#GO:0030030;cellular component assembly#GO:0022607 microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;cilium#GO:0005929;microtubule organizing center#GO:0005815;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 non-motor microtubule binding protein#PC00166;cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=29502|UniProtKB=Q0ZLH3 Q0ZLH3 PJVK PTHR16399:SF10 GASDERMIN PEJVAKIN cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 transporter#PC00227 HUMAN|HGNC=28292|UniProtKB=Q8N6I1 Q8N6I1 EID2 PTHR15556:SF3 EP300-INTERACTING INHIBITOR OF DIFFERENTIATION 2-RELATED EP300-INTERACTING INHIBITOR OF DIFFERENTIATION 2 transcription regulator activity#GO:0140110;transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=29501|UniProtKB=P81274 P81274 GPSM2 PTHR45954:SF3 LD33695P G PROTEIN-SIGNALING MODULATOR 2 binding#GO:0005488;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;protein binding#GO:0005515;molecular function regulator activity#GO:0098772 cytoskeleton organization#GO:0007010;establishment of localization in cell#GO:0051649;establishment of spindle localization#GO:0051293;cellular process#GO:0009987;organelle organization#GO:0006996;establishment of mitotic spindle localization#GO:0040001;mitotic cell cycle process#GO:1903047;establishment of spindle orientation#GO:0051294;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;establishment of mitotic spindle orientation#GO:0000132;establishment of localization#GO:0051234;mitotic cell cycle#GO:0000278;establishment of organelle localization#GO:0051656;establishment of cell polarity#GO:0030010;cell cycle process#GO:0022402;cell cycle#GO:0007049;cellular component organization#GO:0016043;microtubule cytoskeleton organization involved in mitosis#GO:1902850;localization#GO:0051179;cellular localization#GO:0051641;microtubule cytoskeleton organization#GO:0000226;spindle localization#GO:0051653;establishment or maintenance of cell polarity#GO:0007163;organelle localization#GO:0051640 cell cortex#GO:0005938;cell periphery#GO:0071944;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>AGS3#P00715;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>AGS3#P00739 HUMAN|HGNC=11119|UniProtKB=Q99835 Q99835 SMO PTHR11309:SF35 FRIZZLED PROTEIN SMOOTHENED binding#GO:0005488;signaling receptor binding#GO:0005102;transmembrane signaling receptor activity#GO:0004888;Wnt-protein binding#GO:0017147;protein binding#GO:0005515;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;cellular developmental process#GO:0048869;neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;axon guidance#GO:0007411;axon development#GO:0061564;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;pattern specification process#GO:0007389;canonical Wnt signaling pathway#GO:0060070;cell communication#GO:0007154;anatomical structure development#GO:0048856;smoothened signaling pathway#GO:0007224;system development#GO:0048731;non-canonical Wnt signaling pathway#GO:0035567;cellular response to stimulus#GO:0051716;Wnt signaling pathway#GO:0016055;regulation of cellular process#GO:0050794;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell surface receptor signaling pathway#GO:0007166;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cell projection morphogenesis#GO:0048858;neuron projection development#GO:0031175;signal transduction#GO:0007165;cellular process#GO:0009987;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;axonogenesis#GO:0007409;neuron development#GO:0048666;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;central nervous system development#GO:0007417;cell differentiation#GO:0030154;cell projection organization#GO:0030030;response to stimulus#GO:0050896;cell morphogenesis#GO:0000902;signaling#GO:0023052;cell development#GO:0048468 cell periphery#GO:0071944;neuron projection#GO:0043005;membrane#GO:0016020;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;dendritic tree#GO:0097447;cilium#GO:0005929;dendrite#GO:0030425;membrane-bounded organelle#GO:0043227 transmembrane signal receptor#PC00197 Hedgehog signaling pathway#P00025>Smoothened#P00685 HUMAN|HGNC=28363|UniProtKB=Q9H7T9 Q9H7T9 AUNIP PTHR14526:SF2 AURORA KINASE A AND NINEIN-INTERACTING PROTEIN AURORA KINASE A- AND NINEIN-INTERACTING PROTEIN molecular function regulator activity#GO:0098772;molecular sensor activity#GO:0140299 nucleobase-containing compound metabolic process#GO:0006139;cytoskeleton organization#GO:0007010;cellular process#GO:0009987;response to stress#GO:0006950;organelle organization#GO:0006996;double-strand break repair#GO:0006302;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;spindle organization#GO:0007051;macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;DNA recombination#GO:0006310;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;response to stimulus#GO:0050896;cell cycle process#GO:0022402;double-strand break repair via homologous recombination#GO:0000724;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;nucleic acid metabolic process#GO:0090304;cell cycle#GO:0007049;microtubule cytoskeleton organization#GO:0000226;cellular response to stress#GO:0033554;recombinational repair#GO:0000725 chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;site of DNA damage#GO:0090734;membraneless organelle#GO:0043228 HUMAN|HGNC=26342|UniProtKB=Q96LM5 Q96LM5 SPMIP2 PTHR34833:SF1 GENE, 17359-RELATED PROTEIN SPMIP2 HUMAN|HGNC=2926|UniProtKB=Q9UGM3 Q9UGM3 DMBT1 PTHR19331:SF489 SCAVENGER RECEPTOR DOMAIN-CONTAINING SCAVENGER RECEPTOR CYSTEINE-RICH DOMAIN-CONTAINING PROTEIN DMBT1 cargo receptor activity#GO:0038024 response to external biotic stimulus#GO:0043207;defense response to Gram-negative bacterium#GO:0050829;biological process involved in interspecies interaction between organisms#GO:0044419;response to other organism#GO:0051707;response to stimulus#GO:0050896;defense response to Gram-positive bacterium#GO:0050830;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;response to external stimulus#GO:0009605;defense response#GO:0006952;defense response to bacterium#GO:0042742;response to bacterium#GO:0009617 cell periphery#GO:0071944;extracellular region#GO:0005576;extracellular matrix#GO:0031012;membrane#GO:0016020;external encapsulating structure#GO:0030312;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 serine protease#PC00203;protease#PC00190 Integrin signalling pathway#P00034>Integrin alpha#P00941 HUMAN|HGNC=1211|UniProtKB=Q5XX13 Q5XX13 FBXW10 PTHR19872:SF10 UBIQUITIN LIGASE SPECIFICITY FACTOR/HREP PROTEIN F-BOX AND WD REPEAT DOMAIN CONTAINING PROTEIN 10B-RELATED ubiquitin-protein ligase#PC00234 HUMAN|HGNC=13198|UniProtKB=P98168 P98168 ZXDA PTHR46179:SF6 ZINC FINGER PROTEIN ZINC FINGER X-LINKED PROTEIN ZXDA transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218 HUMAN|HGNC=12594|UniProtKB=Q15853 Q15853 USF2 PTHR46117:SF2 FI24210P1 UPSTREAM STIMULATORY FACTOR 2 cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 basic helix-loop-helix transcription factor#PC00055 PDGF signaling pathway#P00047>c-fos#P01145 HUMAN|HGNC=15864|UniProtKB=Q9BYM8 Q9BYM8 RBCK1 PTHR22770:SF35 UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED RANBP-TYPE AND C3HC4-TYPE ZINC FINGER-CONTAINING PROTEIN 1 transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842 positive regulation of signaling#GO:0023056;protein catabolic process#GO:0030163;regulation of signaling#GO:0023051;modification-dependent macromolecule catabolic process#GO:0043632;regulation of intracellular signal transduction#GO:1902531;regulation of biological process#GO:0050789;regulation of non-canonical NF-kappaB signal transduction#GO:1901222;positive regulation of canonical NF-kappaB signal transduction#GO:0043123;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasomal protein catabolic process#GO:0010498;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of non-canonical NF-kappaB signal transduction#GO:1901224;protein metabolic process#GO:0019538;regulation of cell communication#GO:0010646;catabolic process#GO:0009056;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;modification-dependent protein catabolic process#GO:0019941;positive regulation of signal transduction#GO:0009967;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;positive regulation of cellular process#GO:0048522;regulation of canonical NF-kappaB signal transduction#GO:0043122 transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular protein-containing complex#GO:0140535;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=14247|UniProtKB=O75964 O75964 ATP5MG PTHR12386:SF12 ATP SYNTHASE SUBUNIT ATP SYNTHASE F(0) COMPLEX SUBUNIT G, MITOCHONDRIAL-RELATED channel activity#GO:0015267;proton-transporting ATP synthase activity, rotational mechanism#GO:0046933;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic cation channel activity#GO:0005261;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;proton channel activity#GO:0015252;catalytic activity#GO:0003824;proton transmembrane transporter activity#GO:0015078;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;ligase activity#GO:0016874 nucleoside triphosphate metabolic process#GO:0009141;nucleoside phosphate metabolic process#GO:0006753;proton motive force-driven ATP synthesis#GO:0015986;purine nucleoside triphosphate biosynthetic process#GO:0009145;purine nucleoside triphosphate metabolic process#GO:0009144;primary metabolic process#GO:0044238;aerobic respiration#GO:0009060;organophosphate biosynthetic process#GO:0090407;cellular respiration#GO:0045333;oxidative phosphorylation#GO:0006119;purine ribonucleoside triphosphate biosynthetic process#GO:0009206;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;purine ribonucleoside triphosphate metabolic process#GO:0009205;carbohydrate derivative metabolic process#GO:1901135;nucleoside triphosphate biosynthetic process#GO:0009142;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;energy derivation by oxidation of organic compounds#GO:0015980;nucleoside phosphate biosynthetic process#GO:1901293;generation of precursor metabolites and energy#GO:0006091;small molecule metabolic process#GO:0044281;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;proton motive force-driven mitochondrial ATP synthesis#GO:0042776;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;ribonucleotide metabolic process#GO:0009259;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;ATP metabolic process#GO:0046034;ribose phosphate biosynthetic process#GO:0046390;nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative biosynthetic process#GO:1901137;ribonucleoside triphosphate biosynthetic process#GO:0009201;ATP biosynthetic process#GO:0006754;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;proton-transporting ATP synthase complex#GO:0045259;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;mitochondrion#GO:0005739;transmembrane transporter complex#GO:1902495;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;cytoplasm#GO:0005737;membrane#GO:0016020;respiratory chain complex#GO:0098803;transporter complex#GO:1990351;proton-transporting two-sector ATPase complex#GO:0016469;cation channel complex#GO:0034703 ATP synthase#PC00002 HUMAN|HGNC=2428|UniProtKB=P16989 P16989 YBX3 PTHR11544:SF14 COLD SHOCK DOMAIN CONTAINING PROTEINS Y-BOX-BINDING PROTEIN 3 binding#GO:0005488;nucleic acid binding#GO:0003676 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 Gonadotropin-releasing hormone receptor pathway#P06664>Csda#P06797 HUMAN|HGNC=8728|UniProtKB=P22061 P22061 PCMT1 PTHR11579:SF7 PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE PROTEIN-L-ISOASPARTATE(D-ASPARTATE) O-METHYLTRANSFERASE O-methyltransferase activity#GO:0008171;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;catalytic activity, acting on a protein#GO:0140096;protein methyltransferase activity#GO:0008276;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 methyltransferase#PC00155;transferase#PC00220 HUMAN|HGNC=6387|UniProtKB=Q07866 Q07866 KLC1 PTHR45783:SF7 KINESIN LIGHT CHAIN KINESIN LIGHT CHAIN 1 protein binding#GO:0005515;binding#GO:0005488;cytoskeletal protein binding#GO:0008092 cellular process#GO:0009987;microtubule-based movement#GO:0007018;microtubule-based process#GO:0007017 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 microtubule binding motor protein#PC00156 Alzheimer disease-amyloid secretase pathway#P00003>kinesin#P00107 HUMAN|HGNC=16421|UniProtKB=P35712 P35712 SOX6 PTHR45789:SF1 FI18025P1 TRANSCRIPTION FACTOR SOX-6 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 cellular process#GO:0009987;positive regulation of biological process#GO:0048518;nervous system development#GO:0007399;regulation of multicellular organismal process#GO:0051239;positive regulation of cell differentiation#GO:0045597;multicellular organism development#GO:0007275;regulation of multicellular organismal development#GO:2000026;positive regulation of multicellular organismal process#GO:0051240;regulation of biological process#GO:0050789;cell differentiation#GO:0030154;central nervous system development#GO:0007417;regulation of transcription by RNA polymerase II#GO:0006357;animal gross anatomical part developmental process#GO:0160108;cell fate commitment#GO:0045165;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cell differentiation#GO:0045595;developmental process#GO:0032502;positive regulation of developmental process#GO:0051094;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=40037|UniProtKB=Q68DL7 Q68DL7 C18orf63 PTHR28495:SF1 HYPOTHETICAL PROTEIN LOC100359752 GENE, 17266-RELATED sex differentiation#GO:0007548;male gonad development#GO:0008584;gonad development#GO:0008406;multicellular organismal process#GO:0032501;male sex differentiation#GO:0046661;developmental process#GO:0032502;development of primary sexual characteristics#GO:0045137;development of primary male sexual characteristics#GO:0046546;animal organ development#GO:0048513;multicellular organism development#GO:0007275;developmental process involved in reproduction#GO:0003006;reproductive process#GO:0022414;reproductive structure development#GO:0048608;animal gross anatomical part developmental process#GO:0160108;reproductive system development#GO:0061458;system development#GO:0048731;anatomical structure development#GO:0048856 HUMAN|HGNC=26236|UniProtKB=A4FU49 A4FU49 SH3D21 PTHR14167:SF28 SH3 DOMAIN-CONTAINING SH3 DOMAIN-CONTAINING PROTEIN 21 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 scaffold/adaptor protein#PC00226 HUMAN|HGNC=1932|UniProtKB=P36222 P36222 CHI3L1 PTHR11177:SF202 CHITINASE CHITINASE-3-LIKE PROTEIN 1 hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824;chitinase activity#GO:0004568 chitin metabolic process#GO:0006030;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;aminoglycan metabolic process#GO:0006022;amino sugar catabolic process#GO:0046348;aminoglycan catabolic process#GO:0006026;chitin catabolic process#GO:0006032;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;carbohydrate derivative catabolic process#GO:1901136;amino sugar metabolic process#GO:0006040;catabolic process#GO:0009056 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 glycosidase#PC00110;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=5905|UniProtKB=P80748 P80748 IGLV3-21 PTHR23267:SF527 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN LAMBDA VARIABLE 3-21 response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=6275|UniProtKB=Q9HB14 Q9HB14 KCNK13 PTHR11003:SF57 POTASSIUM CHANNEL, SUBFAMILY K POTASSIUM CHANNEL SUBFAMILY K MEMBER 13 voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;outward rectifier potassium channel activity#GO:0015271;potassium channel activity#GO:0005267 transport#GO:0006810;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;cellular process#GO:0009987;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=12511|UniProtKB=P17480 P17480 UBTF PTHR46318:SF4 UPSTREAM BINDING TRANSCRIPTION FACTOR NUCLEOLAR TRANSCRIPTION FACTOR 1 DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;core promoter sequence-specific DNA binding#GO:0001046;double-stranded DNA binding#GO:0003690;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;gene expression#GO:0010467;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;RNA metabolic process#GO:0016070;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;nucleic acid biosynthetic process#GO:0141187;regulation of biological process#GO:0050789;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;positive regulation of transcription by RNA polymerase I#GO:0045943;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;macromolecule biosynthetic process#GO:0009059;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;transcription by RNA polymerase I#GO:0006360;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;regulation of transcription by RNA polymerase I#GO:0006356;positive regulation of RNA metabolic process#GO:0051254;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 General transcription by RNA polymerase I#P00022>UBF1#P00655 HUMAN|HGNC=30073|UniProtKB=Q14181 Q14181 POLA2 PTHR23061:SF12 DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT DNA POLYMERASE ALPHA SUBUNIT B macromolecule metabolic process#GO:0043170;DNA-templated DNA replication#GO:0006261;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;DNA replication initiation#GO:0006270;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;DNA replication#GO:0006260;cellular process#GO:0009987 intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;transferase complex#GO:1990234;DNA polymerase complex#GO:0042575;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;protein-containing complex#GO:0032991;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;membrane-bounded organelle#GO:0043227;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nuclear replication fork#GO:0043596;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;protein-DNA complex#GO:0032993;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;replisome#GO:0030894;nuclear DNA-directed RNA polymerase complex#GO:0055029;replication fork#GO:0005657;chromosome#GO:0005694;organelle lumen#GO:0043233 DNA-directed DNA polymerase#PC00018;DNA metabolism protein#PC00009 HUMAN|HGNC=1972|UniProtKB=Q8NCG5 Q8NCG5 CHST4 PTHR10704:SF40 CARBOHYDRATE SULFOTRANSFERASE CARBOHYDRATE SULFOTRANSFERASE 4 catalytic activity#GO:0003824;transferase activity#GO:0016740;sulfotransferase activity#GO:0008146;transferase activity, transferring sulphur-containing groups#GO:0016782 amino sugar metabolic process#GO:0006040;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;sulfur compound metabolic process#GO:0006790;metabolic process#GO:0008152 Golgi apparatus subcompartment#GO:0098791;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;trans-Golgi network#GO:0005802;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984 transferase#PC00220;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=7909|UniProtKB=Q9UND3 Q9UND3 NPIPA1 PTHR15438:SF14 NUCLEAR PORE COMPLEX INTERACTING PROTEIN NUCLEAR PORE COMPLEX-INTERACTING PROTEIN FAMILY MEMBER A1-RELATED HUMAN|HGNC=14267|UniProtKB=O14917 O14917 PCDH17 PTHR24028:SF41 CADHERIN-87A PROTOCADHERIN-17 anatomical structure development#GO:0048856;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;cell adhesion#GO:0007155;synapse organization#GO:0050808;synapse assembly#GO:0007416;cell junction organization#GO:0034330;cellular component organization#GO:0016043;cell junction assembly#GO:0034329;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;developmental process#GO:0032502;multicellular organismal process#GO:0032501;cellular component assembly#GO:0022607;nervous system development#GO:0007399;cellular component biogenesis#GO:0044085;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cadherin#PC00057;cell adhesion molecule#PC00069 HUMAN|HGNC=28095|UniProtKB=Q6ZP65 Q6ZP65 BICDL1 PTHR32123:SF12 BICD FAMILY-LIKE CARGO ADAPTER BICD FAMILY-LIKE CARGO ADAPTER 1 establishment of organelle localization#GO:0051656;microtubule-based movement#GO:0007018;localization#GO:0051179;cellular localization#GO:0051641;organelle localization#GO:0051640;microtubule-based transport#GO:0099111;cytoskeleton-dependent intracellular transport#GO:0030705;establishment of vesicle localization#GO:0051650;organelle transport along microtubule#GO:0072384;establishment of localization in cell#GO:0051649;vesicle localization#GO:0051648;cellular process#GO:0009987;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;vesicle cytoskeletal trafficking#GO:0099518;microtubule-based process#GO:0007017;intracellular transport#GO:0046907;vesicle transport along microtubule#GO:0047496;transport#GO:0006810 membrane traffic protein#PC00150;membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=23647|UniProtKB=Q9BY15 Q9BY15 ADGRE3 PTHR12011:SF455 ADHESION G-PROTEIN COUPLED RECEPTOR ADHESION G PROTEIN-COUPLED RECEPTOR E3 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=24073|UniProtKB=Q86SJ2 Q86SJ2 AMIGO2 PTHR24368:SF209 AMPHOTERIN-INDUCED PROTEIN AMPHOTERIN-INDUCED PROTEIN 2 multicellular organism development#GO:0007275;animal organ development#GO:0048513;anatomical structure development#GO:0048856;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;cell adhesion#GO:0007155;developmental process#GO:0032502;central nervous system development#GO:0007417;brain development#GO:0007420;multicellular organismal process#GO:0032501;head development#GO:0060322;nervous system development#GO:0007399;cell-cell adhesion#GO:0098609;cellular process#GO:0009987;heterophilic cell-cell adhesion#GO:0007157 cellular anatomical structure#GO:0110165;membrane#GO:0016020 HUMAN|HGNC=16830|UniProtKB=P24001 P24001 IL32 PTHR48490:SF1 INTERLEUKIN-32 INTERLEUKIN-32 HUMAN|HGNC=30526|UniProtKB=Q86TL2 Q86TL2 STIMATE PTHR31735:SF2 VACUOLAR MEMBRANE PROTEIN YPL162C STORE-OPERATED CALCIUM ENTRY REGULATOR STIMATE molecular function regulator activity#GO:0098772;channel regulator activity#GO:0016247;calcium channel regulator activity#GO:0005246;ion channel regulator activity#GO:0099106;transporter regulator activity#GO:0141108 endoplasmic reticulum#GO:0005783;endomembrane system#GO:0012505;cortical endoplasmic reticulum#GO:0032541;cytoplasm#GO:0005737;membrane#GO:0016020;cell periphery#GO:0071944;endoplasmic reticulum tubular network#GO:0071782;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cell cortex#GO:0005938 HUMAN|HGNC=29867|UniProtKB=A6NK97 A6NK97 SLC22A20P PTHR24064:SF34 SOLUTE CARRIER FAMILY 22 MEMBER SOLUTE CARRIER FAMILY 22 MEMBER 20 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 transport#GO:0006810;cellular process#GO:0009987;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 secondary carrier transporter#PC00258 HUMAN|HGNC=31804|UniProtKB=Q7Z2X7 Q7Z2X7 PAGE2 PTHR14047:SF34 P ANTIGEN FAMILY MEMBER 5-RELATED G ANTIGEN FAMILY E MEMBER 3-RELATED HUMAN|HGNC=6554|UniProtKB=P48357 P48357 LEPR PTHR23036:SF109 CYTOKINE RECEPTOR LEPTIN RECEPTOR binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888;protein binding#GO:0005515;molecular transducer activity#GO:0060089;cytokine receptor activity#GO:0004896;immune receptor activity#GO:0140375;signaling receptor activity#GO:0038023;cytokine binding#GO:0019955 cell surface receptor signaling pathway#GO:0007166;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of cellular process#GO:0048522;biological regulation#GO:0065007;response to cytokine#GO:0034097;response to chemical#GO:0042221;cytokine-mediated signaling pathway#GO:0019221;response to peptide#GO:1901652;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;positive regulation of cell population proliferation#GO:0008284;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;signaling receptor complex#GO:0043235;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=15869|UniProtKB=Q96L93 Q96L93 KIF16B PTHR24115:SF400 KINESIN-RELATED KINESIN-LIKE PROTEIN KIF16B plus-end-directed microtubule motor activity#GO:0008574;protein binding#GO:0005515;ATP-dependent activity#GO:0140657;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;cytoskeletal motor activity#GO:0003774;hydrolase activity, acting on acid anhydrides#GO:0016817;cytoskeletal protein binding#GO:0008092;microtubule motor activity#GO:0003777;ATP hydrolysis activity#GO:0016887;hydrolase activity#GO:0016787;polypeptide conformation or assembly isomerase activity#GO:0120544;microtubule binding#GO:0008017;isomerase activity#GO:0016853;ribonucleoside triphosphate phosphatase activity#GO:0017111;macromolecular conformation isomerase activity#GO:0120543;tubulin binding#GO:0015631;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462 microtubule-based movement#GO:0007018;establishment of organelle localization#GO:0051656;localization#GO:0051179;cellular localization#GO:0051641;microtubule-based transport#GO:0099111;organelle localization#GO:0051640;establishment of vesicle localization#GO:0051650;organelle transport along microtubule#GO:0072384;cytoskeleton-dependent intracellular transport#GO:0030705;vesicle localization#GO:0051648;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;vesicle cytoskeletal trafficking#GO:0099518;microtubule-based process#GO:0007017;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;transport#GO:0006810;intracellular transport#GO:0046907;vesicle transport along microtubule#GO:0047496 cellular anatomical structure#GO:0110165;organelle#GO:0043226;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;intracellular organelle#GO:0043229;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=30135|UniProtKB=Q7Z4N8 Q7Z4N8 P4HA3 PTHR10869:SF223 PROLYL 4-HYDROXYLASE ALPHA SUBUNIT PROLYL 4-HYDROXYLASE SUBUNIT ALPHA-3 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824;dioxygenase activity#GO:0051213;oxidoreductase activity#GO:0016491;catalytic activity, acting on a protein#GO:0140096;2-oxoglutarate-dependent dioxygenase activity#GO:0016706 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;oxidoreductase complex#GO:1990204;intracellular anatomical structure#GO:0005622;endoplasmic reticulum protein-containing complex#GO:0140534;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 protein modifying enzyme#PC00260 HUMAN|HGNC=30298|UniProtKB=Q96RL1 Q96RL1 UIMC1 PTHR15932:SF2 UBIQUITIN INTERACTION MOTIF-CONTAINING PROTEIN 1 BRCA1-A COMPLEX SUBUNIT RAP80 histone reader activity#GO:0140566;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;chromatin-protein adaptor activity#GO:0140463 positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;chromatin organization#GO:0006325;positive regulation of DNA repair#GO:0045739;positive regulation of response to stimulus#GO:0048584;regulation of nucleobase-containing compound metabolic process#GO:0019219;DNA damage response#GO:0006974;regulation of response to stimulus#GO:0048583;regulation of DNA repair#GO:0006282;DNA repair#GO:0006281;regulation of response to stress#GO:0080134;macromolecule metabolic process#GO:0043170;cellular response to stimulus#GO:0051716;positive regulation of DNA metabolic process#GO:0051054;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;response to stress#GO:0006950;positive regulation of macromolecule metabolic process#GO:0010604;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;double-strand break repair#GO:0006302;cellular component organization or biogenesis#GO:0071840;regulation of biological process#GO:0050789;regulation of DNA metabolic process#GO:0051052;cellular component organization#GO:0016043;chromatin remodeling#GO:0006338;response to stimulus#GO:0050896;cellular response to stress#GO:0033554;regulation of cellular response to stress#GO:0080135;positive regulation of metabolic process#GO:0009893 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;site of DNA damage#GO:0090734;chromosome#GO:0005694;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;site of double-strand break#GO:0035861;nuclear body#GO:0016604;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991 HUMAN|HGNC=2342|UniProtKB=P43155 P43155 CRAT PTHR22589:SF50 CARNITINE O-ACYLTRANSFERASE CARNITINE O-ACETYLTRANSFERASE acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824;acetyltransferase activity#GO:0016407 modified amino acid metabolic process#GO:0006575;metabolic process#GO:0008152;cellular process#GO:0009987;carnitine metabolic process#GO:0009437 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;microbody#GO:0042579;peroxisome#GO:0005777 metabolite interconversion enzyme#PC00262;acyltransferase#PC00042 HUMAN|HGNC=24289|UniProtKB=Q9Y6K0 Q9Y6K0 CEPT1 PTHR10414:SF27 ETHANOLAMINEPHOSPHOTRANSFERASE CHOLINE_ETHANOLAMINEPHOSPHOTRANSFERASE 1 transferase#PC00220 HUMAN|HGNC=9062|UniProtKB=Q9BRC7 Q9BRC7 PLCD4 PTHR10336:SF31 PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN 1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4 glycerophospholipase activity#GO:0004620;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phospholipase activity#GO:0120569;phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578;lipase activity#GO:0016298;hydrolase activity#GO:0016787 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 hydrolase#PC00121;lipase#PC00143;metabolite interconversion enzyme#PC00262;phospholipase#PC00186 Histamine H1 receptor mediated signaling pathway#P04385>PLC#P04484;Oxytocin receptor mediated signaling pathway#P04391>PLC beta#P04530;5HT2 type receptor mediated signaling pathway#P04374>PLC#P04412;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PLCbetagamma#P00874;Thyrotropin-releasing hormone receptor signaling pathway#P04394>PLC#P04581 HUMAN|HGNC=25753|UniProtKB=Q9H9H5 Q9H9H5 MAP6D1 PTHR14759:SF37 STOP PROTEIN MAP6 DOMAIN-CONTAINING PROTEIN 1 binding#GO:0005488;microtubule binding#GO:0008017;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515 regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;cellular localization#GO:0051641;localization#GO:0051179;regulation of microtubule-based process#GO:0032886;regulation of microtubule cytoskeleton organization#GO:0070507;biological regulation#GO:0065007;cytoskeleton-dependent intracellular transport#GO:0030705;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of localization#GO:0051234;transport#GO:0006810;intracellular transport#GO:0046907 microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;Golgi-associated vesicle#GO:0005798;cytoskeleton#GO:0005856;cis-Golgi network#GO:0005801;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;microtubule#GO:0005874 HUMAN|HGNC=12930|UniProtKB=Q05516 Q05516 ZBTB16 PTHR24393:SF60 ZINC FINGER PROTEIN ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 16 DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;DNA-binding transcription activator activity#GO:0001216;transcription regulator activity#GO:0140110;DNA-binding transcription repressor activity#GO:0001217;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HUMAN|HGNC=28052|UniProtKB=Q9NQH7 Q9NQH7 XPNPEP3 PTHR43226:SF4 XAA-PRO AMINOPEPTIDASE 3 XAA-PRO AMINOPEPTIDASE 3 aminopeptidase activity#GO:0004177;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233 metabolic process#GO:0008152;proteolysis#GO:0006508;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 metalloprotease#PC00153 HUMAN|HGNC=7681|UniProtKB=P52849 P52849 NDST2 PTHR10605:SF53 HEPARAN SULFATE SULFOTRANSFERASE BIFUNCTIONAL HEPARAN SULFATE N-DEACETYLASE_N-SULFOTRANSFERASE 2 transferase activity, transferring sulphur-containing groups#GO:0016782;sulfotransferase activity#GO:0008146;deacetylase activity#GO:0019213;deacylase activity#GO:0160215;catalytic activity#GO:0003824;transferase activity#GO:0016740 glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;proteoglycan metabolic process#GO:0006029;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;protein O-linked glycosylation#GO:0006493;macromolecule biosynthetic process#GO:0009059;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;proteoglycan biosynthetic process#GO:0030166;biosynthetic process#GO:0009058 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;transferase#PC00220 HUMAN|HGNC=24203|UniProtKB=Q8WZ82 Q8WZ82 OVCA2 PTHR48070:SF6 ESTERASE OVCA2 ESTERASE OVCA2 hydrolase activity#GO:0016787;catalytic activity#GO:0003824 nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;esterase#PC00097 HUMAN|HGNC=21483|UniProtKB=Q5T1Q4 Q5T1Q4 SLC35F1 PTHR14233:SF10 DUF914-RELATED SOLUTE CARRIER FAMILY 35 MEMBER F1 HUMAN|HGNC=19205|UniProtKB=Q9P246 Q9P246 STIM2 PTHR15136:SF2 STROMAL INTERACTION MOLECULE HOMOLOG STROMAL INTERACTION MOLECULE 2 metal ion binding#GO:0046872;channel regulator activity#GO:0016247;cation binding#GO:0043169;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;transporter regulator activity#GO:0141108;calcium ion binding#GO:0005509;molecular function regulator activity#GO:0098772;calcium channel regulator activity#GO:0005246;ion channel regulator activity#GO:0099106 monoatomic ion homeostasis#GO:0050801;establishment of localization#GO:0051234;calcium ion transport#GO:0006816;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;transport#GO:0006810;intracellular monoatomic cation homeostasis#GO:0030003;homeostatic process#GO:0042592;metal ion transport#GO:0030001;intracellular monoatomic ion homeostasis#GO:0006873;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;calcium ion homeostasis#GO:0055074;inorganic ion homeostasis#GO:0098771 plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 HUMAN|HGNC=27453|UniProtKB=Q96HE8 Q96HE8 TMEM80 PTHR13531:SF8 GEO07735P1-RELATED-RELATED TRANSMEMBRANE PROTEIN 80 plasma membrane bounded cell projection assembly#GO:0120031;organelle assembly#GO:0070925;cilium organization#GO:0044782;cellular component organization or biogenesis#GO:0071840;non-motile cilium assembly#GO:1905515;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cilium assembly#GO:0060271;cellular component organization#GO:0016043;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cell projection organization#GO:0030030 cilium#GO:0005929;ciliary transition zone#GO:0035869;plasma membrane bounded cell projection#GO:0120025;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=26274|UniProtKB=Q96I59 Q96I59 NARS2 PTHR22594:SF59 ASPARTYL/LYSYL-TRNA SYNTHETASE ASPARAGINYL-TRNA SYNTHETASE catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;ligase activity#GO:0016874 amino acid activation#GO:0043038;macromolecule metabolic process#GO:0043170;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;gene expression#GO:0010467;amino acid metabolic process#GO:0006520;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;tRNA aminoacylation#GO:0043039;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;tRNA aminoacylation for protein translation#GO:0006418;protein metabolic process#GO:0019538;RNA metabolic process#GO:0016070;translation#GO:0006412;protein biosynthetic process#GO:0160307;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 HUMAN|HGNC=7014|UniProtKB=P50222 P50222 MEOX2 PTHR24328:SF1 HOMEOBOX PROTEIN MOX HOMEOBOX PROTEIN MOX-2 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;multicellular organism development#GO:0007275;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;tissue development#GO:0009888;multicellular organismal process#GO:0032501;epithelium development#GO:0060429;regulation of nucleobase-containing compound metabolic process#GO:0019219;embryo development#GO:0009790;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;animal gross anatomical part developmental process#GO:0160108;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 homeodomain transcription factor#PC00119 HUMAN|HGNC=26374|UniProtKB=Q5M9N0 Q5M9N0 CCDC158 PTHR47615:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 158 COILED-COIL DOMAIN-CONTAINING PROTEIN 158 HUMAN|HGNC=14467|UniProtKB=Q8TE54 Q8TE54 SLC26A7 PTHR11814:SF75 SULFATE TRANSPORTER ANION EXCHANGE TRANSPORTER transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;monoatomic anion transmembrane transporter activity#GO:0008509;chloride transmembrane transporter activity#GO:0015108;bicarbonate transmembrane transporter activity#GO:0015106;antiporter activity#GO:0015297;active transmembrane transporter activity#GO:0022804;monoatomic ion transmembrane transporter activity#GO:0015075;dicarboxylic acid transmembrane transporter activity#GO:0005310;carboxylic acid transmembrane transporter activity#GO:0046943 monoatomic anion transport#GO:0006820;cellular process#GO:0009987;monoatomic anion transmembrane transport#GO:0098656;dicarboxylic acid transport#GO:0006835;monoatomic ion transmembrane transport#GO:0034220;chloride transport#GO:0006821;carboxylic acid transport#GO:0046942;transport#GO:0006810;organic acid transport#GO:0015849;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;chloride transmembrane transport#GO:1902476;localization#GO:0051179;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227 HUMAN|HGNC=27815|UniProtKB=Q96C28 Q96C28 ZNF707 PTHR24390:SF129 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 707 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218 HUMAN|HGNC=17780|UniProtKB=Q562R1 Q562R1 ACTBL2 PTHR11937:SF168 ACTIN BETA-ACTIN-LIKE PROTEIN 2 structural constituent of cytoskeleton#GO:0005200;structural molecule activity#GO:0005198 organelle#GO:0043226;glutamatergic synapse#GO:0098978;synapse#GO:0045202;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;actin cytoskeleton#GO:0015629;cell junction#GO:0030054;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 actin and actin related protein#PC00039 Huntington disease#P00029>Actin#P00807;Integrin signalling pathway#P00034>Actin#P00944;Cadherin signaling pathway#P00012>F-actin#P00470;Alzheimer disease-presenilin pathway#P00004>actin#P00114;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>F-actin#P00858;Nicotinic acetylcholine receptor signaling pathway#P00044>Actin#P01090;Cytoskeletal regulation by Rho GTPase#P00016>Actin#P00512 HUMAN|HGNC=29807|UniProtKB=Q6PF18 Q6PF18 MORN3 PTHR46511:SF1 MORN REPEAT-CONTAINING PROTEIN 3 MORN REPEAT-CONTAINING PROTEIN 3 HUMAN|HGNC=24280|UniProtKB=A8MW92 A8MW92 PHF20L1 PTHR15856:SF26 PHD FINGER PROTEIN 20-RELATED PHD FINGER PROTEIN 20-LIKE PROTEIN 1 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219 membraneless organelle#GO:0043228;histone acetyltransferase complex#GO:0000123;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;H4 histone acetyltransferase complex#GO:1902562;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;chromatin#GO:0000785;NSL complex#GO:0044545;acetyltransferase complex#GO:1902493;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;protein acetyltransferase complex#GO:0031248;organelle#GO:0043226;cellular anatomical structure#GO:0110165;chromosome#GO:0005694 HUMAN|HGNC=1790|UniProtKB=P55273 P55273 CDKN2D PTHR24201:SF7 ANK_REP_REGION DOMAIN-CONTAINING PROTEIN CYCLIN-DEPENDENT KINASE 4 INHIBITOR D enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538;enzyme inhibitor activity#GO:0004857;kinase inhibitor activity#GO:0019210;cyclin-dependent protein kinase regulator activity#GO:0019914;protein kinase regulator activity#GO:0019887;protein kinase inhibitor activity#GO:0004860;molecular function regulator activity#GO:0098772;cyclin-dependent protein serine/threonine kinase inhibitor activity#GO:0004861;kinase regulator activity#GO:0019207 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 kinase inhibitor#PC00139;protein-binding activity modulator#PC00095 p53 pathway#P00059>ARF#P01482;p53 pathway#P00059>ARF#G01574 HUMAN|HGNC=26640|UniProtKB=Q8N8Q3 Q8N8Q3 ENDOV PTHR28511:SF1 ENDONUCLEASE V ENDONUCLEASE V RNA nuclease activity#GO:0004540;single-stranded RNA binding#GO:0003727;endonuclease activity#GO:0004519;RNA endonuclease activity#GO:0004521;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;RNA binding#GO:0003723;hydrolase activity#GO:0016787;nuclease activity#GO:0004518;binding#GO:0005488;nucleic acid binding#GO:0003676 intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013 HUMAN|HGNC=29|UniProtKB=O95477 O95477 ABCA1 PTHR19229:SF34 ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA PHOSPHOLIPID-TRANSPORTING ATPASE ABCA1 intramembrane lipid carrier activity#GO:0140303;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657;lipid carrier activity#GO:0005319;phosphatidylcholine intramembrane carrier activity#GO:0008525;molecular carrier activity#GO:0140104;primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804;ATPase-coupled intramembrane lipid carrier activity#GO:0140326;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 macromolecule localization#GO:0033036;phospholipid transport#GO:0015914;lipid transport#GO:0006869;organophosphate ester transport#GO:0015748;transport#GO:0006810;lipid localization#GO:0010876;localization#GO:0051179;establishment of localization#GO:0051234 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229 ATP-binding cassette (ABC) transporter#PC00003 HUMAN|HGNC=9300|UniProtKB=P62714 P62714 PPP2CB PTHR45619:SF44 SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED SERINE_THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM hydrolase activity#GO:0016787;protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578 cell cycle#GO:0007049;cellular process#GO:0009987;mitotic cell cycle#GO:0000278 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 protein modifying enzyme#PC00260;protein phosphatase#PC00195 p53 pathway feedback loops 2#P04398>PP2A-C#P04659;FGF signaling pathway#P00021>PP2A#P00629;Wnt signaling pathway#P00057>PP2A#P01438;p53 pathway by glucose deprivation#P04397>PP2A-C#P04643;p53 pathway#P00059>PP2A#P04630;EGF receptor signaling pathway#P00018>PP2A#P00547 HUMAN|HGNC=3335|UniProtKB=P54852 P54852 EMP3 PTHR10671:SF8 EPITHELIAL MEMBRANE PROTEIN-RELATED EPITHELIAL MEMBRANE PROTEIN 3 cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection assembly#GO:0120031;bleb assembly#GO:0032060;cell projection organization#GO:0030030;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;cell projection assembly#GO:0030031;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 cytoskeletal protein#PC00085 HUMAN|HGNC=14848|UniProtKB=Q8NGN1 Q8NGN1 OR6T1 PTHR26454:SF165 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 6T1 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=23035|UniProtKB=Q96JM7 Q96JM7 L3MBTL3 PTHR12247:SF72 POLYCOMB GROUP PROTEIN LETHAL(3)MALIGNANT BRAIN TUMOR-LIKE PROTEIN 3 binding#GO:0005488;histone binding#GO:0042393;chromatin binding#GO:0003682;protein binding#GO:0005515 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=29040|UniProtKB=Q5T011 Q5T011 SZT2 PTHR14918:SF3 KICSTOR COMPLEX PROTEIN SZT2 KICSTOR COMPLEX PROTEIN SZT2 regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;animal gross anatomical part developmental process#GO:0160108;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648;system development#GO:0048731;negative regulation of intracellular signal transduction#GO:1902532;anatomical structure development#GO:0048856;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;negative regulation of TOR signaling#GO:0032007;central nervous system development#GO:0007417;response to stimulus#GO:0050896;regulation of response to stimulus#GO:0048583;developmental process#GO:0032502;negative regulation of TORC1 signaling#GO:1904262;negative regulation of cellular process#GO:0048523;regulation of TORC1 signaling#GO:1903432;multicellular organism development#GO:0007275;regulation of TOR signaling#GO:0032006;response to nutrient levels#GO:0031667;nervous system development#GO:0007399;negative regulation of signal transduction#GO:0009968;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;multicellular organismal process#GO:0032501;negative regulation of response to stimulus#GO:0048585 vacuole#GO:0005773;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;microbody#GO:0042579;lysosomal membrane#GO:0005765;membrane#GO:0016020;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;lytic vacuole#GO:0000323;vacuolar membrane#GO:0005774;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;lysosome#GO:0005764;peroxisome#GO:0005777;lytic vacuole membrane#GO:0098852;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=17808|UniProtKB=Q9UPT8 Q9UPT8 ZC3H4 PTHR13119:SF23 ZINC FINGER CCCH DOMAIN-CONTAINING PROTEI ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 4 transcription regulator activity#GO:0140110;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription repressor activity#GO:0001217 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;negative regulation of metabolic process#GO:0009892;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;regulation of DNA-templated transcription elongation#GO:0032784 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=18315|UniProtKB=P52198 P52198 RND2 PTHR24072:SF21 RHO FAMILY GTPASE RHO-RELATED GTP-BINDING PROTEIN RHON ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleotide binding#GO:0000166;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;hydrolase activity#GO:0016787;anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167;GTPase activity#GO:0003924;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;ribonucleotide binding#GO:0032553;hydrolase activity, acting on acid anhydrides#GO:0016817;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;protein binding#GO:0005515;guanyl nucleotide binding#GO:0019001;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;kinase binding#GO:0019900;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;nucleoside phosphate binding#GO:1901265 actin filament-based process#GO:0030029;supramolecular fiber organization#GO:0097435;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;signaling#GO:0023052;regulation of cellular process#GO:0050794;actin cytoskeleton organization#GO:0030036;response to stimulus#GO:0050896;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;regulation of actin filament-based process#GO:0032970;actin filament organization#GO:0007015;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;signal transduction#GO:0007165;organelle organization#GO:0006996;regulation of actin cytoskeleton organization#GO:0032956;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007 cytosol#GO:0005829;membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 small GTPase#PC00208;G-protein#PC00020 Integrin signalling pathway#P00034>Rho#P00948 HUMAN|HGNC=697|UniProtKB=Q15041 Q15041 ARL6IP1 PTHR20952:SF0 ADP-RIBOSYLATION-LIKE FACTOR 6-INTERACTING PROTEIN ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 6-INTERACTING PROTEIN 1 endoplasmic reticulum membrane organization#GO:0090158;cellular component organization or biogenesis#GO:0071840;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;endoplasmic reticulum organization#GO:0007029;cellular process#GO:0009987;endoplasmic reticulum tubular network organization#GO:0071786;cellular component assembly#GO:0022607;membrane organization#GO:0061024;endomembrane system organization#GO:0010256 organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endomembrane system#GO:0012505;cytoplasm#GO:0005737;membrane#GO:0016020;endoplasmic reticulum tubular network#GO:0071782;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=17875|UniProtKB=Q96CD0 Q96CD0 FBXL8 PTHR16134:SF141 F-BOX/TPR REPEAT PROTEIN POF3 F-BOX_LRR-REPEAT PROTEIN 8 ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987 protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;cullin-RING ubiquitin ligase complex#GO:0031461;SCF ubiquitin ligase complex#GO:0019005;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;catalytic complex#GO:1902494 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=7777|UniProtKB=Q12968 Q12968 NFATC3 PTHR12533:SF6 NFAT NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;calcineurin-NFAT signaling cascade#GO:0033173;calcineurin-mediated signaling#GO:0097720;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;intracellular signal transduction#GO:0035556;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;regulation of biosynthetic process#GO:0009889;calcium-mediated signaling#GO:0019722;regulation of gene expression#GO:0010468;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;signaling#GO:0023052;regulation of biological process#GO:0050789;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule metabolic process#GO:0010604;intracellular signaling cassette#GO:0141124;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;positive regulation of transcription by RNA polymerase II#GO:0045944 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 Rel homology transcription factor#PC00252;gene-specific transcriptional regulator#PC00264;immunoglobulin fold transcription factor#PC00251 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>NFAT#P00851;Gonadotropin-releasing hormone receptor pathway#P06664>NFAT#P06777;B cell activation#P00010>NFAT#P00367;T cell activation#P00053>NFAT#P01294;Axon guidance mediated by netrin#P00009>NFAT#P00359;Wnt signaling pathway#P00057>NFAT#P01452 HUMAN|Gene=YH009_HUMAN|UniProtKB=A8MV72 A8MV72 PTHR15566:SF10 POM121-LIKE UPF0607 PROTEIN ENSP00000332738-RELATED HUMAN|HGNC=23845|UniProtKB=Q8IY92 Q8IY92 SLX4 PTHR21541:SF3 BTB POZ DOMAIN CONTAINING 12 STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX4 reproductive process#GO:0022414;homologous recombination#GO:0035825;cell cycle#GO:0007049;cellular component organization#GO:0016043;meiosis I#GO:0007127;nucleic acid metabolic process#GO:0090304;meiotic cell cycle process#GO:1903046;primary metabolic process#GO:0044238;reciprocal homologous recombination#GO:0140527;cell cycle process#GO:0022402;organelle fission#GO:0048285;meiosis I cell cycle process#GO:0061982;nuclear division#GO:0000280;sexual reproduction#GO:0019953;reciprocal meiotic recombination#GO:0007131;nucleobase-containing compound metabolic process#GO:0006139;organelle organization#GO:0006996;resolution of meiotic recombination intermediates#GO:0000712;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;meiotic nuclear division#GO:0140013;metabolic process#GO:0008152;meiotic cell cycle#GO:0051321;DNA metabolic process#GO:0006259;DNA recombination#GO:0006310 nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;organelle lumen#GO:0043233 HUMAN|HGNC=6737|UniProtKB=O75608 O75608 LYPLA1 PTHR10655:SF22 LYSOPHOSPHOLIPASE-RELATED ACYL-PROTEIN THIOESTERASE 1 thiolester hydrolase activity#GO:0016790;carboxylic ester hydrolase activity#GO:0052689;phosphatidylcholine lysophospholipase A1 activity#GO:0004622;lipase activity#GO:0016298;hydrolase activity#GO:0016787;palmitoyl hydrolase activity#GO:0098599;hydrolase activity, acting on ester bonds#GO:0016788;phospholipase activity#GO:0120569;catalytic activity#GO:0003824;glycerophospholipase activity#GO:0004620;catalytic activity, acting on a protein#GO:0140096 negative regulation of cellular process#GO:0048523;regulation of establishment of protein localization#GO:0070201;regulation of localization#GO:0032879;regulation of protein localization#GO:0032880;regulation of transport#GO:0051049;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of protein localization to membrane#GO:1905475;regulation of vesicle-mediated transport#GO:0060627;negative regulation of transport#GO:0051051;regulation of protein transport#GO:0051223;regulation of cellular process#GO:0050794;negative regulation of protein transport#GO:0051224;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 phospholipase#PC00186;lipase#PC00143 HUMAN|HGNC=19012|UniProtKB=Q9Y5Q5 Q9Y5Q5 CORIN PTHR24270:SF2 LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED ATRIAL NATRIURETIC PEPTIDE-CONVERTING ENZYME blood circulation#GO:0008015;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;system process#GO:0003008;regulation of biological quality#GO:0065008;regulation of blood pressure#GO:0008217;circulatory system process#GO:0003013 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transfer/carrier protein#PC00219;apolipoprotein#PC00052 HUMAN|HGNC=959|UniProtKB=Q07812 Q07812 BAX PTHR11256:SF42 BCL-2 RELATED APOPTOSIS REGULATOR BAX channel activity#GO:0015267;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;passive transmembrane transporter activity#GO:0022803 regulation of cellular process#GO:0050794;cell death#GO:0008219;cellular response to stimulus#GO:0051716;programmed cell death#GO:0012501;mitochondrial fusion#GO:0008053;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;biological regulation#GO:0065007;negative regulation of apoptotic process#GO:0043066;positive regulation of cellular process#GO:0048522;apoptotic signaling pathway#GO:0097190;DNA damage response#GO:0006974;negative regulation of cellular process#GO:0048523;positive regulation of neuron apoptotic process#GO:0043525;signaling#GO:0023052;release of cytochrome c from mitochondria#GO:0001836;positive regulation of programmed cell death#GO:0043068;response to stimulus#GO:0050896;extrinsic apoptotic signaling pathway#GO:0097191;apoptotic process#GO:0006915;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;intrinsic apoptotic signaling pathway#GO:0097193;cellular response to stress#GO:0033554;apoptotic mitochondrial changes#GO:0008637;mitochondrion organization#GO:0007005;organelle fusion#GO:0048284;cellular process#GO:0009987;negative regulation of programmed cell death#GO:0043069;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;response to stress#GO:0006950;regulation of neuron apoptotic process#GO:0043523;intrinsic apoptotic signaling pathway in response to DNA damage#GO:0008630;organelle organization#GO:0006996;positive regulation of apoptotic process#GO:0043065;cellular component organization or biogenesis#GO:0071840;regulation of apoptotic process#GO:0042981;cell surface receptor signaling pathway#GO:0007166 intracellular organelle#GO:0043229;outer membrane#GO:0019867;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;mitochondrial outer membrane#GO:0005741;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;membrane#GO:0016020;cytoplasm#GO:0005737;organelle outer membrane#GO:0031968 p53 pathway#P00059>BAX#G01581;CCKR signaling map#P06959>BAX#P07159;Huntington disease#P00029>Bax#G01533;Apoptosis signaling pathway#P00006>Bax#P00271 HUMAN|HGNC=31045|UniProtKB=Q96JW4 Q96JW4 SLC41A2 PTHR16228:SF25 DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41 SOLUTE CARRIER FAMILY 41 MEMBER 2 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 secondary carrier transporter#PC00258;transporter#PC00227 HUMAN|HGNC=11204|UniProtKB=P48436 P48436 SOX9 PTHR45803:SF1 SOX100B TRANSCRIPTION FACTOR SOX-9 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 negative regulation of metabolic process#GO:0009892;circulatory system development#GO:0072359;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;central nervous system development#GO:0007417;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;positive regulation of multicellular organismal process#GO:0051240;regulation of multicellular organismal development#GO:2000026;negative regulation of biological process#GO:0048519;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;skeletal system development#GO:0001501;negative regulation of DNA-templated transcription#GO:0045892;animal gross anatomical part developmental process#GO:0160108;nervous system development#GO:0007399;regulation of multicellular organismal process#GO:0051239;heart development#GO:0007507;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;gliogenesis#GO:0042063;morphogenesis of an epithelium#GO:0002009;multicellular organism development#GO:0007275;animal organ development#GO:0048513;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;positive regulation of cell differentiation#GO:0045597;regulation of developmental process#GO:0050793;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;system development#GO:0048731;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;cartilage development#GO:0051216;tissue morphogenesis#GO:0048729;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;epithelium development#GO:0060429;regulation of nucleobase-containing compound metabolic process#GO:0019219;chondrocyte differentiation#GO:0002062;multicellular organismal process#GO:0032501;glial cell differentiation#GO:0010001;tissue development#GO:0009888;oligodendrocyte differentiation#GO:0048709;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;connective tissue development#GO:0061448;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;positive regulation of developmental process#GO:0051094;developmental process#GO:0032502;regulation of cell differentiation#GO:0045595;negative regulation of cellular process#GO:0048523 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;HMG box transcription factor#PC00024 HUMAN|HGNC=11285|UniProtKB=P31213 P31213 SRD5A2 PTHR10556:SF37 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE 2 catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;oxidoreductase activity#GO:0016491 hormone biosynthetic process#GO:0042446;reproductive structure development#GO:0048608;reproductive process#GO:0022414;primary metabolic process#GO:0044238;developmental process involved in reproduction#GO:0003006;regulation of hormone levels#GO:0010817;anatomical structure development#GO:0048856;system development#GO:0048731;regulation of biological quality#GO:0065008;reproductive system development#GO:0061458;animal gross anatomical part developmental process#GO:0160108;hormone metabolic process#GO:0042445;lipid biosynthetic process#GO:0008610;multicellular organismal process#GO:0032501;biosynthetic process#GO:0009058;biological regulation#GO:0065007;steroid metabolic process#GO:0008202;gonad development#GO:0008406;male gonad development#GO:0008584;sex differentiation#GO:0007548;cellular process#GO:0009987;multicellular organism development#GO:0007275;steroid biosynthetic process#GO:0006694;animal organ development#GO:0048513;metabolic process#GO:0008152;development of primary male sexual characteristics#GO:0046546;developmental process#GO:0032502;development of primary sexual characteristics#GO:0045137;lipid metabolic process#GO:0006629;male sex differentiation#GO:0046661 cellular anatomical structure#GO:0110165;somatodendritic compartment#GO:0036477;neuronal cell body#GO:0043025;cell body#GO:0044297 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=9683|UniProtKB=Q92729 Q92729 PTPRU PTHR19134:SF207 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE U catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725;phosphoprotein phosphatase activity#GO:0004721 neuron projection development#GO:0031175;signal transduction#GO:0007165;cellular process#GO:0009987;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;nervous system development#GO:0007399;neuron differentiation#GO:0030182;developmental process#GO:0032502;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;cell differentiation#GO:0030154;cell projection organization#GO:0030030;regulation of cellular process#GO:0050794;signaling#GO:0023052;cell development#GO:0048468;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;cell communication#GO:0007154;anatomical structure development#GO:0048856;system development#GO:0048731;neuron development#GO:0048666 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HUMAN|HGNC=25142|UniProtKB=Q86VG3 Q86VG3 IFTAP PTHR35543:SF1 PROTEIN C11ORF74 INTRAFLAGELLAR TRANSPORT-ASSOCIATED PROTEIN protein-containing complex binding#GO:0044877;binding#GO:0005488 single fertilization#GO:0007338;developmental process involved in reproduction#GO:0003006;acrosome reaction#GO:0007340;gamete generation#GO:0007276;male gamete generation#GO:0048232;fertilization#GO:0009566;reproductive process#GO:0022414;developmental process#GO:0032502;sexual reproduction#GO:0019953;spermatogenesis#GO:0007283;multicellular organismal reproductive process#GO:0048609 cilium#GO:0005929;intracellular anatomical structure#GO:0005622;non-motile cilium#GO:0097730;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;9+0 non-motile cilium#GO:0097731;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=24123|UniProtKB=Q9UPM9 Q9UPM9 B9D1 PTHR12968:SF1 B9 DOMAIN-CONTAINING B9 DOMAIN-CONTAINING PROTEIN 1 cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component assembly#GO:0022607;cell projection organization#GO:0030030;plasma membrane bounded cell projection organization#GO:0120036;organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031;cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782 membrane-bounded organelle#GO:0043227;cilium#GO:0005929;ciliary transition zone#GO:0035869;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 structural protein#PC00211 HUMAN|HGNC=4139|UniProtKB=Q8TET4 Q8TET4 GANC PTHR22762:SF60 ALPHA-GLUCOSIDASE NEUTRAL ALPHA-GLUCOSIDASE C hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824;glucosidase activity#GO:0015926;alpha-glucosidase activity#GO:0090599;hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798 glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;biosynthetic process#GO:0009058;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137 glucosidase#PC00108 HUMAN|HGNC=11645|UniProtKB=Q9UH92 Q9UH92 MLX PTHR15741:SF25 BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR MAX-LIKE PROTEIN X transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218 HUMAN|HGNC=30894|UniProtKB=Q765I0 Q765I0 UTS2B PTHR36876:SF1 UROTENSIN-2B UROTENSIN-2B protein binding#GO:0005515;G protein-coupled receptor binding#GO:0001664;binding#GO:0005488;signaling receptor binding#GO:0005102 regulation of biological quality#GO:0065008;system process#GO:0003008;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;blood circulation#GO:0008015;circulatory system process#GO:0003013;regulation of blood pressure#GO:0008217 HUMAN|HGNC=18538|UniProtKB=Q9BXS6 Q9BXS6 NUSAP1 PTHR15874:SF1 NUCLEOLAR AND SPINDLE-ASSOCIATED PROTEIN 1 NUCLEOLAR AND SPINDLE-ASSOCIATED PROTEIN 1 protein binding#GO:0005515;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;microtubule binding#GO:0008017 establishment of localization#GO:0051234;chromosome organization#GO:0051276;mitotic cell cycle process#GO:1903047;mitotic sister chromatid segregation#GO:0000070;establishment of spindle localization#GO:0051293;organelle localization#GO:0051640;organelle fission#GO:0048285;microtubule cytoskeleton organization#GO:0000226;localization#GO:0051179;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cell cycle#GO:0007049;cell division#GO:0051301;mitotic cytokinesis#GO:0000281;mitotic cell cycle#GO:0000278;chromosome segregation#GO:0007059;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;establishment of mitotic spindle localization#GO:0040001;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;cytoskeleton organization#GO:0007010;cytokinesis#GO:0000910;nuclear division#GO:0000280;spindle localization#GO:0051653;cellular localization#GO:0051641;cytoskeleton-dependent cytokinesis#GO:0061640;chromosome condensation#GO:0030261;mitotic chromosome condensation#GO:0007076;nuclear chromosome segregation#GO:0098813;cellular component organization#GO:0016043;sister chromatid segregation#GO:0000819;cell cycle process#GO:0022402;mitotic nuclear division#GO:0140014;establishment of organelle localization#GO:0051656 intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membraneless organelle#GO:0043228;spindle#GO:0005819;cytoskeleton#GO:0005856;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;mitotic spindle#GO:0072686;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 HUMAN|HGNC=24615|UniProtKB=O00418 O00418 EEF2K PTHR45992:SF12 EUKARYOTIC ELONGATION FACTOR 2 KINASE-RELATED EUKARYOTIC ELONGATION FACTOR 2 KINASE transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;calcium/calmodulin-dependent protein kinase activity#GO:0004683;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;regulation of macromolecule biosynthetic process#GO:0010556;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;post-transcriptional regulation of gene expression#GO:0010608 cell junction#GO:0030054;postsynaptic density#GO:0014069;cellular anatomical structure#GO:0110165;neuron to neuron synapse#GO:0098984;synapse#GO:0045202;asymmetric synapse#GO:0032279;organelle#GO:0043226;postsynaptic specialization#GO:0099572;postsynapse#GO:0098794 Oxidative stress response#P00046>eEF2K#P01127;p38 MAPK pathway#P05918>eEF2K#P06022 HUMAN|HGNC=18886|UniProtKB=P59534 P59534 TAS2R39 PTHR11394:SF142 TASTE RECEPTOR TYPE 2 TASTE RECEPTOR TYPE 2 MEMBER 39 transmembrane signaling receptor activity#GO:0004888;bitter taste receptor activity#GO:0033038;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;taste receptor activity#GO:0008527 detection of chemical stimulus involved in sensory perception of bitter taste#GO:0001580;system process#GO:0003008;sensory perception of taste#GO:0050909;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception#GO:0007600;nervous system process#GO:0050877;detection of chemical stimulus involved in sensory perception of taste#GO:0050912;response to chemical#GO:0042221;response to stimulus#GO:0050896;multicellular organismal process#GO:0032501;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;sensory perception of bitter taste#GO:0050913;detection of chemical stimulus#GO:0009593 cellular anatomical structure#GO:0110165;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=8621|UniProtKB=P23759 P23759 PAX7 PTHR45636:SF26 PAIRED BOX PROTEIN PAX-6-RELATED-RELATED PAIRED BOX PROTEIN PAX-7 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;nervous system development#GO:0007399;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;multicellular organism development#GO:0007275;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;animal gross anatomical part developmental process#GO:0160108 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 HUMAN|HGNC=5579|UniProtKB=A0A0B4J2B6 A0A0B4J2B6 IGHV2OR16-5 PTHR23266:SF240 IMMUNOGLOBULIN HEAVY CHAIN IG-LIKE DOMAIN-CONTAINING PROTEIN antigen binding#GO:0003823;binding#GO:0005488 immune response#GO:0006955;adaptive immune response#GO:0002250;response to stimulus#GO:0050896;immune effector process#GO:0002252;immune system process#GO:0002376;immunoglobulin mediated immune response#GO:0016064;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=5235|UniProtKB=P54652 P54652 HSPA2 PTHR19375:SF382 HEAT SHOCK PROTEIN 70KDA HEAT SHOCK-RELATED 70 KDA PROTEIN 2 hydrolase activity, acting on acid anhydrides#GO:0016817;heat shock protein binding#GO:0031072;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;ATP-dependent activity#GO:0140657;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;ATP hydrolysis activity#GO:0016887;protein binding#GO:0005515;hydrolase activity#GO:0016787 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein folding#GO:0006457;biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467;metabolic process#GO:0008152;protein refolding#GO:0042026;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 chaperone#PC00072;Hsp70 family chaperone#PC00027 Parkinson disease#P00049>Hsp70#P01208;Apoptosis signaling pathway#P00006>HSP70#P00321 HUMAN|HGNC=22247|UniProtKB=Q8NEG2 Q8NEG2 C7orf57 PTHR31097:SF2 SI:DKEY-276J7.1 CHROMOSOME 7 OPEN READING FRAME 57 HUMAN|HGNC=6703|UniProtKB=Q9Y608 Q9Y608 LRRFIP2 PTHR19212:SF6 LEUCINE RICH REPEAT IN FLII INTERACTING PROTEIN LEUCINE-RICH REPEAT FLIGHTLESS-INTERACTING PROTEIN 2 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=10537|UniProtKB=P49591 P49591 SARS1 PTHR11778:SF7 SERYL-TRNA SYNTHETASE SERINE--TRNA LIGASE, CYTOPLASMIC RNA binding#GO:0003723;tRNA binding#GO:0000049;catalytic activity, acting on a tRNA#GO:0140101;binding#GO:0005488;nucleic acid binding#GO:0003676;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;ligase activity#GO:0016874 gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;tRNA aminoacylation#GO:0043039;tRNA aminoacylation for protein translation#GO:0006418;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;amino acid activation#GO:0043038;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;cytoplasmic translation#GO:0002181;protein biosynthetic process#GO:0160307;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA metabolic process#GO:0016070;protein metabolic process#GO:0019538;translation#GO:0006412 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 translational protein#PC00263;aminoacyl-tRNA synthetase#PC00047 HUMAN|HGNC=19268|UniProtKB=Q8N2K1 Q8N2K1 UBE2J2 PTHR24068:SF135 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2 J2 aminoacyltransferase activity#GO:0016755;ubiquitin conjugating enzyme activity#GO:0061631;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein conjugating enzyme activity#GO:0061650;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746 protein ubiquitination#GO:0016567;proteasomal protein catabolic process#GO:0010498;post-translational protein modification#GO:0043687;response to chemical#GO:0042221;cellular process#GO:0009987;response to stress#GO:0006950;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;catabolic process#GO:0009056;response to stimulus#GO:0050896;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;protein modification process#GO:0036211;ERAD pathway#GO:0036503;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;protein modification by small protein conjugation or removal#GO:0070647;response to endoplasmic reticulum stress#GO:0034976 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234 Parkinson disease#P00049>Ubc6#P01222 HUMAN|HGNC=30349|UniProtKB=Q9Y535 Q9Y535 POLR3H PTHR12709:SF1 DNA-DIRECTED RNA POLYMERASE II, III DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8 nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;transcription by RNA polymerase III#GO:0006383;DNA-templated transcription initiation#GO:0006352;transcription initiation at RNA polymerase III promoter#GO:0006384;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774 transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;RNA polymerase III complex#GO:0005666;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA-directed RNA polymerase#PC00019;RNA metabolism protein#PC00031 HUMAN|HGNC=28255|UniProtKB=Q96HM7 Q96HM7 PCED1B PTHR14469:SF1 SARCOMA ANTIGEN NY-SAR-23 PC-ESTERASE DOMAIN-CONTAINING PROTEIN 1B HUMAN|HGNC=29138|UniProtKB=Q9Y6X4 Q9Y6X4 FAM169A PTHR22442:SF3 FAMILY NOT NAMED SOLUBLE LAMIN-ASSOCIATED PROTEIN OF 75 KDA HUMAN|HGNC=30425|UniProtKB=Q9NQ36 Q9NQ36 SCUBE2 PTHR24046:SF3 SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 2 signal transduction#GO:0007165;cellular process#GO:0009987;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;biological regulation#GO:0065007;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;cellular response to BMP stimulus#GO:0071773;response to BMP#GO:0071772;developmental process#GO:0032502;cell surface receptor signaling pathway#GO:0007166;cellular developmental process#GO:0048869;muscle cell development#GO:0055001;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;muscle cell differentiation#GO:0042692;BMP signaling pathway#GO:0030509;cellular response to stimulus#GO:0051716;cell differentiation#GO:0030154;response to stimulus#GO:0050896;response to growth factor#GO:0070848;cellular response to endogenous stimulus#GO:0071495;muscle structure development#GO:0061061;regulation of cellular process#GO:0050794;signaling#GO:0023052;cell development#GO:0048468;animal gross anatomical part developmental process#GO:0160108;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;cellular response to growth factor stimulus#GO:0071363;smoothened signaling pathway#GO:0007224 cell periphery#GO:0071944;extracellular region#GO:0005576;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 extracellular matrix glycoprotein#PC00100 HUMAN|HGNC=22992|UniProtKB=Q96LD8 Q96LD8 SENP8 PTHR46468:SF1 SENTRIN-SPECIFIC PROTEASE 8 SENTRIN-SPECIFIC PROTEASE 8 catalytic activity#GO:0003824;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 macromolecule metabolic process#GO:0043170;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152;post-translational protein modification#GO:0043687;cellular process#GO:0009987;protein modification process#GO:0036211;primary metabolic process#GO:0044238 protease#PC00190 HUMAN|HGNC=28808|UniProtKB=Q63HQ0 Q63HQ0 AP1AR PTHR34529:SF1 AP-1 COMPLEX-ASSOCIATED REGULATORY PROTEIN AP-1 COMPLEX-ASSOCIATED REGULATORY PROTEIN binding#GO:0005488;protein-containing complex binding#GO:0044877 cellular process#GO:0009987;Golgi to endosome transport#GO:0006895;establishment of localization in cell#GO:0051649;cytosolic transport#GO:0016482;vesicle-mediated transport#GO:0016192;Golgi vesicle transport#GO:0048193;transport#GO:0006810;intracellular transport#GO:0046907;post-Golgi vesicle-mediated transport#GO:0006892;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179 intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular vesicle#GO:0097708;vesicle#GO:0031982;transport vesicle#GO:0030133;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|Ensembl=ENSG00000288137.1|UniProtKB=A0AAG2TWI1 A0AAG2TWI1 PTHR12138:SF167 PRIMATE-EXPANDED PROTEIN FAMILY SECRETED PROTEIN HUMAN|HGNC=13552|UniProtKB=P98196 P98196 ATP11A PTHR24092:SF33 PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE PHOSPHOLIPID-TRANSPORTING ATPASE IH intramembrane lipid carrier activity#GO:0140303;ATP-dependent activity#GO:0140657;ATPase-coupled intramembrane lipid carrier activity#GO:0140326;transporter activity#GO:0005215;lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104 regulation of membrane lipid distribution#GO:0097035;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;transport#GO:0006810;phospholipid translocation#GO:0045332;biological regulation#GO:0065007;phospholipid transport#GO:0015914;membrane organization#GO:0061024;lipid transport#GO:0006869;cellular process#GO:0009987;macromolecule localization#GO:0033036;regulation of biological quality#GO:0065008;localization#GO:0051179;lipid localization#GO:0010876;lipid translocation#GO:0034204;organophosphate ester transport#GO:0015748;cellular component organization#GO:0016043 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;endomembrane system#GO:0012505;endoplasmic reticulum#GO:0005783;recycling endosome#GO:0055037;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622 primary active transporter#PC00068;transporter#PC00227 HUMAN|HGNC=22140|UniProtKB=Q8IXL6 Q8IXL6 FAM20C PTHR12450:SF11 DENTIN MATRIX PROTEIN 4 PROTEIN FAM20 EXTRACELLULAR SERINE_THREONINE PROTEIN KINASE FAM20C protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824 animal organ development#GO:0048513;anatomical structure development#GO:0048856;anatomical structure formation involved in morphogenesis#GO:0048646;animal gross anatomical part developmental process#GO:0160108;enamel mineralization#GO:0070166;biomineral tissue development#GO:0031214;developmental process#GO:0032502;odontogenesis of dentin-containing tooth#GO:0042475;tissue development#GO:0009888;animal organ morphogenesis#GO:0009887;odontogenesis#GO:0042476;anatomical structure morphogenesis#GO:0009653;amelogenesis#GO:0097186 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;extracellular region#GO:0005576;Golgi apparatus#GO:0005794 HUMAN|HGNC=30740|UniProtKB=Q9BW92 Q9BW92 TARS2 PTHR11451:SF27 THREONINE-TRNA LIGASE THREONINE--TRNA LIGASE, MITOCHONDRIAL ligase activity#GO:0016874;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a tRNA#GO:0140101 nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;gene expression#GO:0010467;tRNA aminoacylation for protein translation#GO:0006418;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;tRNA aminoacylation#GO:0043039;macromolecule metabolic process#GO:0043170;amino acid activation#GO:0043038;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;protein biosynthetic process#GO:0160307;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;RNA metabolic process#GO:0016070;translation#GO:0006412 aminoacyl-tRNA synthetase#PC00047 HUMAN|HGNC=9182|UniProtKB=Q9UNA4 Q9UNA4 POLI PTHR46404:SF1 DNA POLYMERASE IOTA DNA POLYMERASE IOTA DNA-directed DNA polymerase activity#GO:0003887;catalytic activity#GO:0003824;transferase activity#GO:0016740;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772;DNA polymerase activity#GO:0034061;catalytic activity, acting on DNA#GO:0140097 macromolecule metabolic process#GO:0043170;DNA metabolic process#GO:0006259;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;DNA damage tolerance#GO:0006301;DNA damage response#GO:0006974;translesion synthesis#GO:0019985;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;response to stress#GO:0006950;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;DNA biosynthetic process#GO:0071897;DNA synthesis involved in DNA replication#GO:0090592;nucleic acid biosynthetic process#GO:0141187;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;DNA replication#GO:0006260;cellular response to stimulus#GO:0051716 DNA metabolism protein#PC00009 HUMAN|HGNC=10970|UniProtKB=Q4U2R8 Q4U2R8 SLC22A6 PTHR24064:SF294 SOLUTE CARRIER FAMILY 22 MEMBER SOLUTE CARRIER FAMILY 22 MEMBER 6 active transmembrane transporter activity#GO:0022804;antiporter activity#GO:0015297;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 transport#GO:0006810;carboxylic acid transport#GO:0046942;organic acid transport#GO:0015849;lipid localization#GO:0010876;monocarboxylic acid transport#GO:0015718;system process#GO:0003008;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;fatty acid transport#GO:0015908;renal system process#GO:0003014;cellular process#GO:0009987;macromolecule localization#GO:0033036;multicellular organismal process#GO:0032501;lipid transport#GO:0006869 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258 HUMAN|HGNC=27997|UniProtKB=O60809 O60809 PRAMEF10 PTHR14224:SF28 SIMILAR TO PREFERENTIALLY EXPRESSED ANTIGEN IN MELANOMA-LIKE 3 PRAME FAMILY MEMBER 10-RELATED ubiquitin-like ligase-substrate adaptor activity#GO:1990756;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;enzyme-substrate adaptor activity#GO:0140767 metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;cullin-RING ubiquitin ligase complex#GO:0031461;ubiquitin ligase complex#GO:0000151;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;Cul2-RING ubiquitin ligase complex#GO:0031462;transferase complex#GO:1990234;catalytic complex#GO:1902494 HUMAN|HGNC=15879|UniProtKB=Q8WYA6 Q8WYA6 CTNNBL1 PTHR14978:SF4 BETA-CATENIN-LIKE PROTEIN 1 NUCLEAR ASSOCIATED PROTEIN BETA-CATENIN-LIKE PROTEIN 1 macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;mRNA splicing, via spliceosome#GO:0000398;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 nucleus#GO:0005634;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;Prp19 complex#GO:0000974;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 HUMAN|HGNC=1440|UniProtKB=P30988 P30988 CALCR PTHR45620:SF8 PDF RECEPTOR-LIKE PROTEIN-RELATED CALCITONIN RECEPTOR signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;molecular transducer activity#GO:0060089;G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888 regulation of biological quality#GO:0065008;cell communication#GO:0007154;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;positive regulation of cytosolic calcium ion concentration#GO:0007204;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165 axon#GO:0030424;plasma membrane#GO:0005886;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165;neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=467|UniProtKB=Q9Y4X0 Q9Y4X0 AMMECR1 PTHR13016:SF2 AMMECR1 HOMOLOG NUCLEAR PROTEIN AMMECR1 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=24567|UniProtKB=Q9BWH6 Q9BWH6 RPAP1 PTHR21483:SF18 RNA POLYMERASE II-ASSOCIATED PROTEIN 1 RNA POLYMERASE II-ASSOCIATED PROTEIN 1 HUMAN|HGNC=5624|UniProtKB=A0A0B4J1X5 A0A0B4J1X5 IGHV3-74 PTHR23266:SF406 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 3-74 antigen binding#GO:0003823;binding#GO:0005488 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;immune effector process#GO:0002252;immune system process#GO:0002376;adaptive immune response#GO:0002250;response to stimulus#GO:0050896;immune response#GO:0006955 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=17058|UniProtKB=Q6ICL7 Q6ICL7 SLC35E4 PTHR11132:SF293 SOLUTE CARRIER FAMILY 35 SOLUTE CARRIER FAMILY 35 MEMBER E4 secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;antiporter activity#GO:0015297;active transmembrane transporter activity#GO:0022804 cellular process#GO:0009987;transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085 bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;membrane#GO:0016020 transporter#PC00227;secondary carrier transporter#PC00258 HUMAN|HGNC=11019|UniProtKB=Q06495 Q06495 SLC34A1 PTHR10010:SF21 SOLUTE CARRIER FAMILY 34 SODIUM PHOSPHATE , MEMBER 2-RELATED SODIUM-DEPENDENT PHOSPHATE TRANSPORT PROTEIN 2A sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;solute:monoatomic cation symporter activity#GO:0015294;monoatomic ion transmembrane transporter activity#GO:0015075;secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic cation transmembrane transporter activity#GO:0008324;solute:sodium symporter activity#GO:0015370;symporter activity#GO:0015293;phosphate transmembrane transporter activity#GO:0005315 cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;inorganic anion transport#GO:0015698;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810;chemical homeostasis#GO:0048878;inorganic ion homeostasis#GO:0098771;phosphate ion transport#GO:0006817;homeostatic process#GO:0042592 apical plasma membrane#GO:0016324;membrane#GO:0016020;vesicle#GO:0031982;brush border#GO:0005903;cell periphery#GO:0071944;organelle#GO:0043226;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;apical part of cell#GO:0045177;membrane-bounded organelle#GO:0043227;cluster of actin-based cell projections#GO:0098862 secondary carrier transporter#PC00258 HUMAN|HGNC=24473|UniProtKB=Q6UWY5 Q6UWY5 OLFML1 PTHR23192:SF13 OLFACTOMEDIN-RELATED OLFACTOMEDIN-LIKE PROTEIN 1 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 structural protein#PC00211 HUMAN|HGNC=2964|UniProtKB=Q13409 Q13409 DYNC1I2 PTHR12442:SF37 DYNEIN INTERMEDIATE CHAIN CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN 2 binding#GO:0005488;protein binding#GO:0005515 microtubule-based movement#GO:0007018;cytoskeleton-dependent intracellular transport#GO:0030705;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;microtubule-based process#GO:0007017;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;microtubule-based transport#GO:0099111;transport#GO:0006810;intracellular transport#GO:0046907 microtubule cytoskeleton#GO:0015630;cytoplasmic dynein complex#GO:0005868;dynein complex#GO:0030286;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 microtubule or microtubule-binding cytoskeletal protein#PC00157 Huntington disease#P00029>Dynein complex#P00774 HUMAN|HGNC=29860|UniProtKB=Q6DHY5 Q6DHY5 TBC1D3G PTHR22957:SF571 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN TBC1 DOMAIN FAMILY MEMBER 3-RELATED enzyme activator activity#GO:0008047;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772 protein-binding activity modulator#PC00095;G-protein modulator#PC00022;GTPase-activating protein#PC00257 HUMAN|HGNC=21336|UniProtKB=Q9NTX7 Q9NTX7 RNF146 PTHR13417:SF2 E3 UBIQUITIN-PROTEIN LIGASE RNF146 E3 UBIQUITIN-PROTEIN LIGASE RNF146 aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;carbohydrate derivative binding#GO:0097367;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;binding#GO:0005488 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;catabolic process#GO:0009056;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=21647|UniProtKB=Q9Y2X8 Q9Y2X8 UBE2D4 PTHR24068:SF541 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2 D4 aminoacyltransferase activity#GO:0016755;ubiquitin conjugating enzyme activity#GO:0061631;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-like protein conjugating enzyme activity#GO:0061650;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746 protein K11-linked ubiquitination#GO:0070979;protein modification process#GO:0036211;primary metabolic process#GO:0044238;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;protein polyubiquitination#GO:0000209;catabolic process#GO:0009056;protein modification by small protein conjugation or removal#GO:0070647;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;cellular process#GO:0009987;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;metabolic process#GO:0008152;protein K48-linked ubiquitination#GO:0070936;macromolecule catabolic process#GO:0009057;macromolecule metabolic process#GO:0043170;protein K63-linked ubiquitination#GO:0070534;ubiquitin-dependent protein catabolic process#GO:0006511 ubiquitin-protein ligase#PC00234 Ubiquitin proteasome pathway#P00060>E2#P01491 HUMAN|HGNC=26225|UniProtKB=Q8IV53 Q8IV53 DENND1C PTHR13196:SF25 DENN DOMAIN-CONTAINING DENN DOMAIN-CONTAINING PROTEIN 1C phosphatidylinositol phosphate binding#GO:1901981;lipid binding#GO:0008289;binding#GO:0005488;phospholipid binding#GO:0005543 vesicle-mediated transport to the plasma membrane#GO:0098876;endosomal transport#GO:0016197;establishment of localization#GO:0051234;import into cell#GO:0098657;cellular localization#GO:0051641;localization#GO:0051179;transport#GO:0006810;localization within membrane#GO:0051668;intracellular transport#GO:0046907;vesicle-mediated transport#GO:0016192;endocytosis#GO:0006897;endocytic recycling#GO:0032456;cellular process#GO:0009987;establishment of localization in cell#GO:0051649 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytosol#GO:0005829;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=24684|UniProtKB=Q8N302 Q8N302 AGGF1 PTHR23106:SF24 ANGIOGENIC FACTOR WITH G PATCH AND FHA DOMAINS 1 ANGIOGENIC FACTOR WITH G PATCH AND FHA DOMAINS 1 tube morphogenesis#GO:0035239;blood vessel development#GO:0001568;anatomical structure morphogenesis#GO:0009653;blood vessel morphogenesis#GO:0048514;tube development#GO:0035295;multicellular organismal process#GO:0032501;circulatory system development#GO:0072359;developmental process#GO:0032502;animal gross anatomical part developmental process#GO:0160108;vasculature development#GO:0001944;anatomical structure formation involved in morphogenesis#GO:0048646;system development#GO:0048731;anatomical structure development#GO:0048856;angiogenesis#GO:0001525;multicellular organism development#GO:0007275 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=11621|UniProtKB=P20823 P20823 HNF1A PTHR11568:SF4 HEPATOCYTE NUCLEAR FACTOR 1 HEPATOCYTE NUCLEAR FACTOR 1-ALPHA transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 HUMAN|HGNC=993|UniProtKB=Q9HD36 Q9HD36 BCL2L10 PTHR11256:SF47 BCL-2 RELATED BCL-2-LIKE PROTEIN 10 channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 DNA damage response#GO:0006974;negative regulation of cellular process#GO:0048523;apoptotic signaling pathway#GO:0097190;positive regulation of cellular process#GO:0048522;biological regulation#GO:0065007;negative regulation of apoptotic process#GO:0043066;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cell death#GO:0008219;programmed cell death#GO:0012501;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;regulation of apoptotic process#GO:0042981;cellular component organization or biogenesis#GO:0071840;positive regulation of apoptotic process#GO:0043065;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;negative regulation of programmed cell death#GO:0043069;response to stress#GO:0006950;intrinsic apoptotic signaling pathway in response to DNA damage#GO:0008630;organelle organization#GO:0006996;apoptotic mitochondrial changes#GO:0008637;mitochondrion organization#GO:0007005;cellular response to stress#GO:0033554;intrinsic apoptotic signaling pathway#GO:0097193;apoptotic process#GO:0006915;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;signaling#GO:0023052;release of cytochrome c from mitochondria#GO:0001836;positive regulation of programmed cell death#GO:0043068;extrinsic apoptotic signaling pathway#GO:0097191;response to stimulus#GO:0050896 outer membrane#GO:0019867;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;mitochondrial outer membrane#GO:0005741;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;membrane#GO:0016020;cytoplasm#GO:0005737;organelle outer membrane#GO:0031968 Apoptosis signaling pathway#P00006>Diva#P00285 HUMAN|HGNC=17950|UniProtKB=Q969J3 Q969J3 BORCS5 PTHR31634:SF2 BLOC-1-RELATED COMPLEX SUBUNIT 5 BLOC-1-RELATED COMPLEX SUBUNIT 5 regulation of biological process#GO:0050789;regulation of microtubule-based movement#GO:0060632;regulation of cellular process#GO:0050794;establishment of organelle localization#GO:0051656;microtubule-based movement#GO:0007018;microtubule-based transport#GO:0099111;organelle localization#GO:0051640;regulation of microtubule-based process#GO:0032886;localization#GO:0051179;cellular localization#GO:0051641;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;establishment of localization in cell#GO:0051649;positive regulation of transport#GO:0051050;cellular process#GO:0009987;lysosome localization#GO:0032418;biological regulation#GO:0065007;organelle transport along microtubule#GO:0072384;cytoskeleton-dependent intracellular transport#GO:0030705;transport#GO:0006810;intracellular transport#GO:0046907;regulation of localization#GO:0032879;regulation of transport#GO:0051049;microtubule-based process#GO:0007017;transport along microtubule#GO:0010970;establishment of localization#GO:0051234 transport vesicle membrane#GO:0030658;endomembrane system#GO:0012505;transport vesicle#GO:0030133;membrane#GO:0016020;vesicle membrane#GO:0012506;vacuolar membrane#GO:0005774;intracellular protein-containing complex#GO:0140535;organelle membrane#GO:0031090;intracellular membrane-bounded organelle#GO:0043231;synaptic vesicle#GO:0008021;vesicle#GO:0031982;synaptic vesicle membrane#GO:0030672;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;vacuole#GO:0005773;secretory vesicle#GO:0099503;lysosomal membrane#GO:0005765;presynapse#GO:0098793;cell junction#GO:0030054;lytic vacuole#GO:0000323;bounding membrane of organelle#GO:0098588;cytoplasmic side of membrane#GO:0098562;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;lytic vacuole membrane#GO:0098852;intracellular vesicle#GO:0097708;lysosome#GO:0005764;side of membrane#GO:0098552;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229 HUMAN|HGNC=11729|UniProtKB=Q15554 Q15554 TERF2 PTHR46833:SF1 TELOMERIC REPEAT-BINDING FACTOR 2 TERF2 TELOMERIC REPEAT-BINDING FACTOR 2 binding#GO:0005488;single-stranded DNA binding#GO:0003697;DNA polymerase activity#GO:0034061;telomerase activity#GO:0003720;catalytic activity, acting on DNA#GO:0140097;telomeric repeat DNA binding#GO:0042162;sequence-specific DNA binding#GO:0043565;transferase activity#GO:0016740;DNA binding#GO:0003677;RNA-directed DNA polymerase activity#GO:0003964;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772 regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of DNA metabolic process#GO:0051053;macromolecule localization#GO:0033036;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;intracellular protein localization#GO:0008104;regulation of telomere maintenance#GO:0032204;chromosome organization#GO:0051276;telomere maintenance#GO:0000723;regulation of chromosome organization#GO:0033044;negative regulation of cellular process#GO:0048523;DNA damage response#GO:0006974;regulation of macromolecule metabolic process#GO:0060255;protein localization to organelle#GO:0033365;regulation of cellular process#GO:0050794;negative regulation of DNA recombination#GO:0045910;negative regulation of organelle organization#GO:0010639;primary metabolic process#GO:0044238;negative regulation of cellular component organization#GO:0051129;nucleic acid metabolic process#GO:0090304;cellular response to stimulus#GO:0051716;localization#GO:0051179;telomere organization#GO:0032200;negative regulation of chromosome organization#GO:2001251;telomere capping#GO:0016233;organelle organization#GO:0006996;response to stress#GO:0006950;regulation of telomere maintenance via telomere lengthening#GO:1904356;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;response to stimulus#GO:0050896;regulation of cellular component organization#GO:0051128;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of DNA metabolic process#GO:0051052;regulation of organelle organization#GO:0033043;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of DNA recombination#GO:0000018;cellular response to stress#GO:0033554 nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;chromosome, telomeric region#GO:0000781;intracellular organelle#GO:0043229;nuclear telomere cap complex#GO:0000783;membrane-bounded organelle#GO:0043227;chromosome, telomeric repeat region#GO:0140445;intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687;chromosome#GO:0005694;protein-DNA complex#GO:0032993;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=11326|UniProtKB=P51571 P51571 SSR4 PTHR12731:SF1 TRANSLOCON-ASSOCIATED PROTEIN, DELTA SUBUNIT TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT DELTA endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 HUMAN|HGNC=21152|UniProtKB=Q496Y0 Q496Y0 LONRF3 PTHR23327:SF41 RING FINGER PROTEIN 127 LON PEPTIDASE N-TERMINAL DOMAIN AND RING FINGER PROTEIN 3 ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=6277|UniProtKB=O95069 O95069 KCNK2 PTHR11003:SF21 POTASSIUM CHANNEL, SUBFAMILY K POTASSIUM CHANNEL SUBFAMILY K MEMBER 2 monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;transporter activity#GO:0005215;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated monoatomic ion channel activity#GO:0005244;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;monoatomic cation channel activity#GO:0005261;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;outward rectifier potassium channel activity#GO:0015271;potassium channel activity#GO:0005267 establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;transport#GO:0006810;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 ion channel#PC00133;transporter#PC00227 HUMAN|HGNC=17442|UniProtKB=Q8WX39 Q8WX39 LCN9 PTHR11430:SF28 LIPOCALIN EPIDIDYMAL-SPECIFIC LIPOCALIN-9 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 transfer/carrier protein#PC00219 HUMAN|HGNC=5434|UniProtKB=P01574 P01574 IFNB1 PTHR11691:SF73 TYPE I INTERFERON INTERFERON BETA molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;protein binding#GO:0005515;molecular function activator activity#GO:0140677;protein-containing complex binding#GO:0044877;cytokine activity#GO:0005125;binding#GO:0005488;cytokine receptor binding#GO:0005126;signaling receptor binding#GO:0005102 response to peptide#GO:1901652;cell activation involved in immune response#GO:0002263;type I interferon-mediated signaling pathway#GO:0060337;B cell activation involved in immune response#GO:0002312;immune system process#GO:0002376;biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052;response to stimulus#GO:0050896;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;T cell activation#GO:0042110;B cell activation#GO:0042113;natural killer cell activation#GO:0030101;cell surface receptor signaling pathway#GO:0007166;immune effector process#GO:0002252;leukocyte activation involved in immune response#GO:0002366;humoral immune response#GO:0006959;T cell activation involved in immune response#GO:0002286;defense response to other organism#GO:0098542;response to chemical#GO:0042221;lymphocyte activation#GO:0046649;response to cytokine#GO:0034097;cellular process#GO:0009987;lymphocyte activation involved in immune response#GO:0002285;signal transduction#GO:0007165;defense response to symbiont#GO:0140546;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;response to nitrogen compound#GO:1901698;cell communication#GO:0007154;cell activation#GO:0001775;cytokine-mediated signaling pathway#GO:0019221;response to external biotic stimulus#GO:0043207;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;leukocyte activation#GO:0045321;defense response#GO:0006952;response to external stimulus#GO:0009605;innate immune response#GO:0045087;response to other organism#GO:0051707;adaptive immune response#GO:0002250;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;immune response#GO:0006955 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 interferon superfamily#PC00127;cytokine#PC00083 Toll receptor signaling pathway#P00054>Gene trancription#G01550 HUMAN|HGNC=22420|UniProtKB=Q9BT73 Q9BT73 PSMG3 PTHR31051:SF1 PROTEASOME ASSEMBLY CHAPERONE 3 PROTEASOME ASSEMBLY CHAPERONE 3 chaperone#PC00072 HUMAN|HGNC=17315|UniProtKB=Q99595 Q99595 TIMM17A PTHR10485:SF1 MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM-17 MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM17-A transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;transmembrane protein transporter activity#GO:0008320 mitochondrial transport#GO:0006839;protein localization to organelle#GO:0033365;protein localization to mitochondrion#GO:0070585;protein transport#GO:0015031;localization#GO:0051179;cellular localization#GO:0051641;transmembrane transport#GO:0055085;mitochondrial transmembrane transport#GO:1990542;mitochondrial protein import pathway#GO:7770058;protein import into mitochondrial matrix#GO:0030150;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;macromolecule localization#GO:0033036;intracellular protein localization#GO:0008104;establishment of protein localization to organelle#GO:0072594;intracellular protein transmembrane transport#GO:0065002;establishment of localization#GO:0051234;protein transmembrane import into intracellular organelle#GO:0044743;protein transmembrane transport#GO:0071806;intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907 membrane protein complex#GO:0098796;organelle envelope#GO:0031967;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;TIM23 mitochondrial import inner membrane translocase complex#GO:0005744;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;cytoplasm#GO:0005737;inner mitochondrial membrane protein complex#GO:0098800;organelle membrane#GO:0031090 transporter#PC00227 HUMAN|HGNC=6004|UniProtKB=Q6UXL0 Q6UXL0 IL20RB PTHR20859:SF48 INTERFERON/INTERLEUKIN RECEPTOR INTERLEUKIN-20 RECEPTOR SUBUNIT BETA cytokine receptor activity#GO:0004896;immune receptor activity#GO:0140375;signaling receptor activity#GO:0038023;cytokine binding#GO:0019955;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;protein binding#GO:0005515 response to peptide#GO:1901652;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;cytokine-mediated signaling pathway#GO:0019221;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;response to chemical#GO:0042221;response to cytokine#GO:0034097;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;signal transduction#GO:0007165 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=16789|UniProtKB=Q9BZQ4 Q9BZQ4 NMNAT2 PTHR12039:SF18 NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE NICOTINAMIDE_NICOTINIC ACID MONONUCLEOTIDE ADENYLYLTRANSFERASE 2 nucleotidyltransferase activity#GO:0016779;transferase activity#GO:0016740;catalytic activity#GO:0003824;adenylyltransferase activity#GO:0070566;transferase activity, transferring phosphorus-containing groups#GO:0016772 NAD+ metabolic process#GO:0019674;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;nicotinamide nucleotide metabolic process#GO:0046496;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing small molecule metabolic process#GO:0055086;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;pyridine-containing compound metabolic process#GO:0072524;organophosphate biosynthetic process#GO:0090407;nucleotide metabolic process#GO:0009117;nucleotide biosynthetic process#GO:0009165 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 nucleotidyltransferase#PC00174;transferase#PC00220 HUMAN|HGNC=33629|UniProtKB=Q9Y6R9 Q9Y6R9 CCDC61 PTHR22691:SF1 YEAST SPT2-RELATED CENTROSOMAL PROTEIN CCDC61 microtubule cytoskeleton#GO:0015630;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;cilium#GO:0005929;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;ciliary basal body#GO:0036064;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=18824|UniProtKB=Q96N95 Q96N95 ZNF396 PTHR23226:SF78 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER PROTEIN 396 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=9465|UniProtKB=P11908 P11908 PRPS2 PTHR10210:SF123 RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 2 transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824 nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;nucleotide biosynthetic process#GO:0009165;organophosphate biosynthetic process#GO:0090407;nucleotide metabolic process#GO:0009117;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;carbohydrate derivative metabolic process#GO:1901135;ribose phosphate biosynthetic process#GO:0046390;organophosphate metabolic process#GO:0019637;nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative biosynthetic process#GO:1901137;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 transferase complex#GO:1990234;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;nucleotide kinase#PC00172 HUMAN|HGNC=30774|UniProtKB=Q6VUC0 Q6VUC0 TFAP2E PTHR10812:SF13 TRANSCRIPTION FACTOR AP-2 TRANSCRIPTION FACTOR AP-2-EPSILON transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription activator activity#GO:0001216;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of cell population proliferation#GO:0042127;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;regulation of biological process#GO:0050789;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 RNA metabolism protein#PC00031;general transcription factor#PC00259 HUMAN|HGNC=11036|UniProtKB=P13866 P13866 SLC5A1 PTHR11819:SF197 SOLUTE CARRIER FAMILY 5 SODIUM_GLUCOSE COTRANSPORTER 1 secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;solute:monoatomic cation symporter activity#GO:0015294;sugar transmembrane transporter activity#GO:0051119;monoatomic ion transmembrane transporter activity#GO:0015075;symporter activity#GO:0015293;monoatomic cation transmembrane transporter activity#GO:0008324;carbohydrate transmembrane transporter activity#GO:0015144;solute:sodium symporter activity#GO:0015370 system process#GO:0003008;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;import into cell#GO:0098657;renal absorption#GO:0070293;localization#GO:0051179;transport#GO:0006810;carbohydrate transport#GO:0008643;carbohydrate transmembrane transport#GO:0034219;multicellular organismal process#GO:0032501;import across plasma membrane#GO:0098739;cellular process#GO:0009987;renal system process#GO:0003014;D-glucose transmembrane transport#GO:1904659 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;cell periphery#GO:0071944;apical part of cell#GO:0045177;membrane#GO:0016020;apical plasma membrane#GO:0016324 transporter#PC00227;secondary carrier transporter#PC00258 HUMAN|HGNC=12799|UniProtKB=Q9NZC7 Q9NZC7 WWOX PTHR24320:SF304 RETINOL DEHYDROGENASE WW DOMAIN-CONTAINING OXIDOREDUCTASE oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;alcohol dehydrogenase (NADP+) activity#GO:0008106;oxidoreductase activity#GO:0016491;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824 response to growth factor#GO:0070848;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;cellular response to growth factor stimulus#GO:0071363;response to endogenous stimulus#GO:0009719;response to transforming growth factor beta#GO:0071559;cellular response to transforming growth factor beta stimulus#GO:0071560 dehydrogenase#PC00092;oxidoreductase#PC00176 HUMAN|HGNC=1377|UniProtKB=P35218 P35218 CA5A PTHR18952:SF89 CARBONIC ANHYDRASE CARBONIC ANHYDRASE 5A, MITOCHONDRIAL carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;hydro-lyase activity#GO:0016836;catalytic activity#GO:0003824 mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;dehydratase#PC00091 HUMAN|HGNC=9974|UniProtKB=Q9Y644 Q9Y644 RFNG PTHR10811:SF1 FRINGE-RELATED BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE RADICAL FRINGE UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;acetylglucosaminyltransferase activity#GO:0008375;transferase activity#GO:0016740;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758 regulation of biological process#GO:0050789;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of Notch signaling pathway#GO:0008593;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583 glycosyltransferase#PC00111;transferase#PC00220 Notch signaling pathway#P00045>Fringe#P01107 HUMAN|HGNC=27411|UniProtKB=Q6PIF2 Q6PIF2 SYCE2 PTHR28398:SF1 SYNAPTONEMAL COMPLEX CENTRAL ELEMENT PROTEIN 2 SYNAPTONEMAL COMPLEX CENTRAL ELEMENT PROTEIN 2 cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;chromosome#GO:0005694;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;central element#GO:0000801;synaptonemal structure#GO:0099086;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membraneless organelle#GO:0043228;condensed nuclear chromosome#GO:0000794;synaptonemal complex#GO:0000795;condensed chromosome#GO:0000793 HUMAN|HGNC=7697|UniProtKB=O95178 O95178 NDUFB2 PTHR15223:SF1 NADH-UBIQUINONE OXIDOREDUCTASE AGGG SUBUNIT NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 2, MITOCHONDRIAL mitochondrial ATP synthesis coupled electron transport#GO:0042775;respiratory electron transport chain#GO:0022904;cellular process#GO:0009987;electron transport chain#GO:0022900;aerobic respiration#GO:0009060;oxidative phosphorylation#GO:0006119;ATP synthesis coupled electron transport#GO:0042773;energy derivation by oxidation of organic compounds#GO:0015980;cellular respiration#GO:0045333;generation of precursor metabolites and energy#GO:0006091;mitochondrial electron transport, NADH to ubiquinone#GO:0006120;metabolic process#GO:0008152;aerobic electron transport chain#GO:0019646 catalytic complex#GO:1902494;respiratory chain complex I#GO:0045271;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;membrane protein complex#GO:0098796;membrane#GO:0016020;oxidoreductase complex#GO:1990204;respiratory chain complex#GO:0098803;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=13342|UniProtKB=Q9NZS2 Q9NZS2 KLRF1 PTHR46746:SF7 KILLER CELL LECTIN-LIKE RECEPTOR SUBFAMILY F MEMBER 2 KILLER CELL LECTIN-LIKE RECEPTOR SUBFAMILY F MEMBER 1 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=4719|UniProtKB=P16401 P16401 H1-5 PTHR11467:SF24 HISTONE H1 HISTONE H1.5 chromatin binding#GO:0003682;binding#GO:0005488;nucleic acid binding#GO:0003676;nucleosome binding#GO:0031491;double-stranded DNA binding#GO:0003690;protein-containing complex binding#GO:0044877;DNA binding#GO:0003677;chromatin DNA binding#GO:0031490 regulation of biological process#GO:0050789;regulation of DNA metabolic process#GO:0051052;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;negative regulation of DNA recombination#GO:0045910;negative regulation of metabolic process#GO:0009892;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of DNA recombination#GO:0000018;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;chromosome condensation#GO:0030261;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;organelle organization#GO:0006996;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;negative regulation of DNA metabolic process#GO:0051053;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of cellular process#GO:0048523;chromosome organization#GO:0051276;cellular component organization or biogenesis#GO:0071840 chromosome#GO:0005694;nucleus#GO:0005634;chromatin#GO:0000785;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=4892|UniProtKB=Q93099 Q93099 HGD PTHR11056:SF0 HOMOGENTISATE 1,2-DIOXYGENASE HOMOGENTISATE 1,2-DIOXYGENASE oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen#GO:0016702;oxidoreductase activity#GO:0016491;dioxygenase activity#GO:0051213;catalytic activity#GO:0003824 metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;amino acid metabolic process#GO:0006520;small molecule catabolic process#GO:0044282;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;proteinogenic amino acid metabolic process#GO:0170039 oxygenase#PC00177;oxidoreductase#PC00176 HUMAN|HGNC=18038|UniProtKB=Q96A83 Q96A83 COL26A1 PTHR15427:SF19 EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER COLLAGEN ALPHA-1(XXVI) CHAIN positive regulation of cell adhesion#GO:0045785;positive regulation of cell-substrate adhesion#GO:0010811;regulation of biological process#GO:0050789;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of cell-substrate adhesion#GO:0010810;biological regulation#GO:0065007;regulation of cell adhesion#GO:0030155;regulation of cellular process#GO:0050794 scaffold/adaptor protein#PC00226 HUMAN|HGNC=18884|UniProtKB=Q9NUW8 Q9NUW8 TDP1 PTHR12415:SF0 TYROSYL-DNA PHOSPHODIESTERASE 1 TYROSYL-DNA PHOSPHODIESTERASE 1 single-stranded DNA binding#GO:0003697;binding#GO:0005488;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on DNA#GO:0140097;phosphoric diester hydrolase activity#GO:0008081 cellular response to stress#GO:0033554;DNA damage response#GO:0006974;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;primary metabolic process#GO:0044238;nucleobase-containing compound metabolic process#GO:0006139;response to stimulus#GO:0050896 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 phosphodiesterase#PC00185 HUMAN|HGNC=24110|UniProtKB=O14530 O14530 TXNDC9 PTHR21148:SF11 THIOREDOXIN DOMAIN-CONTAINING PROTEIN 9 THIOREDOXIN DOMAIN-CONTAINING PROTEIN 9 organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226;cytoskeleton organization#GO:0007010;microtubule-based process#GO:0007017 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protein-binding activity modulator#PC00095 HUMAN|HGNC=593|UniProtKB=O15392 O15392 BIRC5 PTHR46771:SF3 DETERIN BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 5 spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;mitotic cell cycle process#GO:1903047;negative regulation of cellular process#GO:0048523;regulation of apoptotic process#GO:0042981;chromosome segregation#GO:0007059;negative regulation of apoptotic process#GO:0043066;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular process#GO:0009987;negative regulation of programmed cell death#GO:0043069;microtubule cytoskeleton organization#GO:0000226;cytoskeleton-dependent cytokinesis#GO:0061640;cytokinesis#GO:0000910;mitotic cytokinesis#GO:0000281;mitotic spindle organization#GO:0007052;regulation of cellular process#GO:0050794;mitotic cell cycle#GO:0000278;cellular component organization#GO:0016043;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cell cycle#GO:0007049;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;cell division#GO:0051301;cell cycle process#GO:0022402;regulation of biological process#GO:0050789 spindle midzone#GO:0051233;intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;kinetochore#GO:0000776;chromosome#GO:0005694;membraneless organelle#GO:0043228;spindle#GO:0005819;condensed chromosome#GO:0000793;cytoskeleton#GO:0005856;chromosome, centromeric region#GO:0000775;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;microtubule cytoskeleton#GO:0015630;condensed chromosome, centromeric region#GO:0000779 Angiogenesis#P00005>Survivin#P00198 HUMAN|HGNC=18608|UniProtKB=Q38SD2 Q38SD2 LRRK1 PTHR48055:SF46 LEUCINE-RICH REPEAT RECEPTOR PROTEIN KINASE EMS1 LEUCINE-RICH REPEAT SERINE_THREONINE-PROTEIN KINASE 1 phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 transmembrane signal receptor#PC00197 HUMAN|HGNC=26889|UniProtKB=Q3SXZ3 Q3SXZ3 ZNF718 PTHR24384:SF208 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED ZINC FINGER PROTEIN 718 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218 HUMAN|HGNC=24539|UniProtKB=Q8NC96 Q8NC96 NECAP1 PTHR12847:SF15 ATP-BINDING CASSETTE ABC TRANSPORTER-RELATED ADAPTIN EAR-BINDING COAT-ASSOCIATED PROTEIN 1 vesicle membrane#GO:0012506;membrane#GO:0016020;vesicle coat#GO:0030120;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;clathrin vesicle coat#GO:0030125;clathrin-coated vesicle#GO:0030136;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;clathrin-coated vesicle membrane#GO:0030665;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;coated vesicle membrane#GO:0030662;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;clathrin coat#GO:0030118;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;coated vesicle#GO:0030135;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;coated membrane#GO:0048475;membrane coat#GO:0030117 ATP-binding cassette (ABC) transporter#PC00003 HUMAN|HGNC=20328|UniProtKB=Q6PH85 Q6PH85 DCUN1D2 PTHR12281:SF16 RP42 RELATED DCN1-LIKE PROTEIN 2 ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;binding#GO:0005488;protein binding#GO:0005515;catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 positive regulation of protein metabolic process#GO:0051247;regulation of protein modification process#GO:0031399;positive regulation of metabolic process#GO:0009893;regulation of post-translational protein modification#GO:1901873;regulation of biological process#GO:0050789;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of protein modification by small protein conjugation or removal#GO:1903320;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of macromolecule metabolic process#GO:0010604 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=13414|UniProtKB=Q9NZK7 Q9NZK7 PLA2G2E PTHR11716:SF56 PHOSPHOLIPASE A2 FAMILY MEMBER GROUP IIE SECRETORY PHOSPHOLIPASE A2 metal ion binding#GO:0046872;lipid binding#GO:0008289;binding#GO:0005488;calcium ion binding#GO:0005509;A2-type glycerophospholipase activity#GO:0004623;glycerophospholipase activity#GO:0004620;phospholipase activity#GO:0120569;hydrolase activity#GO:0016787;cation binding#GO:0043169;ion binding#GO:0043167;small molecule binding#GO:0036094;lipase activity#GO:0016298;carboxylic ester hydrolase activity#GO:0052689;catalytic activity#GO:0003824;phospholipid binding#GO:0005543;hydrolase activity, acting on ester bonds#GO:0016788 metabolic process#GO:0008152;lipid metabolic process#GO:0006629;phosphatidylcholine metabolic process#GO:0046470;phosphatidylglycerol metabolic process#GO:0046471;glycerolipid metabolic process#GO:0046486;glycerophospholipid metabolic process#GO:0006650;phospholipid metabolic process#GO:0006644;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987 phospholipase#PC00186 HUMAN|HGNC=26935|UniProtKB=Q9Y3I0 Q9Y3I0 RTCB PTHR11118:SF1 RNA-SPLICING LIGASE RTCB HOMOLOG RNA-SPLICING LIGASE RTCB catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;ligase activity#GO:0016874;catalytic activity, acting on RNA#GO:0140098 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;tRNA splicing, via endonucleolytic cleavage and ligation#GO:0006388;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;intracellular organelle#GO:0043229;catalytic complex#GO:1902494 HUMAN|HGNC=24565|UniProtKB=Q7Z3B3 Q7Z3B3 KANSL1 PTHR22443:SF14 NON-SPECIFIC LETHAL 1, ISOFORM M KAT8 REGULATORY NSL COMPLEX SUBUNIT 1 enzyme binding#GO:0019899;binding#GO:0005488;protein binding#GO:0005515 protein acetyltransferase complex#GO:0031248;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;NSL complex#GO:0044545;intracellular anatomical structure#GO:0005622;acetyltransferase complex#GO:1902493;chromosome#GO:0005694;cellular anatomical structure#GO:0110165;organelle#GO:0043226;transferase complex#GO:1990234;membraneless organelle#GO:0043228;intracellular protein-containing complex#GO:0140535;histone acetyltransferase complex#GO:0000123;chromatin#GO:0000785;protein-containing complex#GO:0032991;H4 histone acetyltransferase complex#GO:1902562;intracellular membraneless organelle#GO:0043232 HUMAN|HGNC=1181|UniProtKB=Q9Y2G1 Q9Y2G1 MYRF PTHR13029:SF16 FAMILY NOT NAMED MYELIN REGULATORY FACTOR sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;transcription regulator activity#GO:0140110;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676 system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;protein metabolic process#GO:0019538;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;primary metabolic process#GO:0044238;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;macromolecule metabolic process#GO:0043170;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;biosynthetic process#GO:0009058;regulation of RNA biosynthetic process#GO:2001141;membrane organization#GO:0061024;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nucleobase-containing compound metabolic process#GO:0019219;oligodendrocyte differentiation#GO:0048709;positive regulation of DNA-templated transcription#GO:0045893;multicellular organismal process#GO:0032501;glial cell differentiation#GO:0010001;positive regulation of cellular process#GO:0048522;macromolecule biosynthetic process#GO:0009059;protein processing#GO:0016485;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;plasma membrane organization#GO:0007009;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;proteolysis#GO:0006508;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;central nervous system development#GO:0007417;cell differentiation#GO:0030154;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;gliogenesis#GO:0042063;myelination#GO:0042552;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;metabolic process#GO:0008152;endomembrane system organization#GO:0010256;nervous system development#GO:0007399;positive regulation of macromolecule metabolic process#GO:0010604;protein maturation#GO:0051604;gene expression#GO:0010467;positive regulation of biological process#GO:0048518;cellular process#GO:0009987 organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endomembrane system#GO:0012505;cytoplasm#GO:0005737;membrane#GO:0016020;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=12024|UniProtKB=P16562 P16562 CRISP2 PTHR10334:SF572 CYSTEINE-RICH SECRETORY PROTEIN-RELATED CYSTEINE-RICH SECRETORY PROTEIN 2 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090 HUMAN|HGNC=25476|UniProtKB=Q9NWD8 Q9NWD8 TMEM248 PTHR16002:SF5 TRANSMEMBRANE PROTEIN 248-LIKE TRANSMEMBRANE PROTEIN 248 HUMAN|HGNC=19005|UniProtKB=Q9C098 Q9C098 DCLK3 PTHR24347:SF427 SERINE/THREONINE-PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE DCLK3 protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=2704|UniProtKB=P27707 P27707 DCK PTHR10513:SF19 DEOXYNUCLEOSIDE KINASE DEOXYCYTIDINE KINASE deoxynucleoside kinase activity#GO:0019136;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleobase-containing compound kinase activity#GO:0019205 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739 nucleotide kinase#PC00172;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=7866|UniProtKB=Q13253 Q13253 NOG PTHR10494:SF5 BONE MORPHOGENETIC PROTEIN INHIBITOR, NOGGIN NOGGIN molecular function inhibitor activity#GO:0140678;molecular function regulator activity#GO:0098772 pattern specification process#GO:0007389;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;negative regulation of cell communication#GO:0010648;skeletal system development#GO:0001501;anatomical structure development#GO:0048856;dorsal/ventral pattern formation#GO:0009953;regulation of biological process#GO:0050789;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092;negative regulation of biological process#GO:0048519;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;developmental process#GO:0032502;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;negative regulation of BMP signaling pathway#GO:0030514;multicellular organism development#GO:0007275;regulation of BMP signaling pathway#GO:0030510;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cellular response to growth factor stimulus#GO:0090287;negative regulation of signal transduction#GO:0009968;negative regulation of response to stimulus#GO:0048585;multicellular organismal process#GO:0032501;regionalization#GO:0003002 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HUMAN|HGNC=29176|UniProtKB=Q684P5 Q684P5 RAP1GAP2 PTHR15711:SF17 RAP GTPASE-ACTIVATING PROTEIN RAP1 GTPASE-ACTIVATING PROTEIN 2 GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047 axon#GO:0030424;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;neuron projection#GO:0043005;membrane#GO:0016020 GTPase-activating protein#PC00257;G-protein modulator#PC00022 HUMAN|HGNC=20342|UniProtKB=Q96MV8 Q96MV8 ZDHHC15 PTHR22883:SF270 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE ZDHHC15 acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740;palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity, acting on a protein#GO:0140096 protein targeting#GO:0006605;cellular component organization#GO:0016043;localization#GO:0051179;cellular localization#GO:0051641;localization within membrane#GO:0051668;developmental maturation#GO:0021700;establishment of protein localization#GO:0045184;cellular process#GO:0009987;organelle organization#GO:0006996;establishment of protein localization to membrane#GO:0090150;vesicle organization#GO:0016050;cellular component organization or biogenesis#GO:0071840;synaptic vesicle maturation#GO:0016188;establishment of localization#GO:0051234;developmental process#GO:0032502;protein targeting to membrane#GO:0006612 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 protein modifying enzyme#PC00260 HUMAN|HGNC=1729|UniProtKB=P21127 P21127 CDK11B PTHR24056:SF599 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE 11A-RELATED transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of mRNA processing#GO:0050684;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of mRNA metabolic process#GO:1903311;regulation of biosynthetic process#GO:0009889 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=26720|UniProtKB=Q6AZW8 Q6AZW8 ZNF660 PTHR24390:SF260 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 383-RELATED RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 DNA-binding transcription factor#PC00218;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=16643|UniProtKB=Q14BN4 Q14BN4 SLMAP PTHR15715:SF22 CENTROSOMAL PROTEIN OF 170 KDA SARCOLEMMAL MEMBRANE-ASSOCIATED PROTEIN protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 regulation of membrane potential#GO:0042391;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of response to stimulus#GO:0048585;regulation of biological quality#GO:0065008;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of hippo signaling#GO:0035331;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;regulation of cell communication#GO:0010646;regulation of hippo signaling#GO:0035330;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519 membrane#GO:0016020;organelle envelope#GO:0031967;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227 scaffold/adaptor protein#PC00226 HUMAN|HGNC=23248|UniProtKB=Q3SYC2 Q3SYC2 MOGAT2 PTHR12317:SF74 DIACYLGLYCEROL O-ACYLTRANSFERASE 2-ACYLGLYCEROL O-ACYLTRANSFERASE 2 acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740 neutral lipid metabolic process#GO:0006638;metabolic process#GO:0008152;acylglycerol metabolic process#GO:0006639;triglyceride metabolic process#GO:0006641;lipid metabolic process#GO:0006629;glycerolipid metabolic process#GO:0046486;triglyceride biosynthetic process#GO:0019432;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;membrane#GO:0016020;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum membrane#GO:0005789 acyltransferase#PC00042;transferase#PC00220 HUMAN|HGNC=14124|UniProtKB=Q12980 Q12980 NPRL3 PTHR13153:SF5 CGTHBA PROTEIN -14 GENE PROTEIN GATOR1 COMPLEX PROTEIN NPRL3 regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of autophagy#GO:0010506;response to stimulus#GO:0050896;regulation of signaling#GO:0023051;cellular response to stress#GO:0033554;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;positive regulation of metabolic process#GO:0009893;cellular process#GO:0009987;regulation of TOR signaling#GO:0032006;positive regulation of biological process#GO:0048518;response to stress#GO:0006950;positive regulation of autophagy#GO:0010508;negative regulation of signal transduction#GO:0009968;cellular response to amino acid starvation#GO:0034198;negative regulation of TORC1 signaling#GO:1904262;cellular response to stimulus#GO:0051716;response to starvation#GO:0042594;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;negative regulation of TOR signaling#GO:0032007;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;response to nutrient levels#GO:0031667;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of response to stimulus#GO:0048585;regulation of response to stimulus#GO:0048583;cellular response to nutrient levels#GO:0031669;negative regulation of cellular process#GO:0048523;cellular response to starvation#GO:0009267;regulation of catabolic process#GO:0009894;regulation of TORC1 signaling#GO:1903432;positive regulation of catabolic process#GO:0009896 Seh1-associated complex#GO:0035859;protein-containing complex#GO:0032991 HUMAN|HGNC=19664|UniProtKB=Q9UK08 Q9UK08 GNG8 PTHR13809:SF19 GUANINE NUCLEOTIDE-BINDING PROTEIN GAMMA SUBUNIT GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)_G(S)_G(O) SUBUNIT GAMMA-8 molecular function regulator activity#GO:0098772;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;cytoplasmic side of plasma membrane#GO:0009898;membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;extrinsic component of plasma membrane#GO:0019897;side of membrane#GO:0098552;extrinsic component of membrane#GO:0019898;cytoplasmic side of membrane#GO:0098562;extrinsic component of cytoplasmic side of plasma membrane#GO:0031234;catalytic complex#GO:1902494 heterotrimeric G-protein#PC00117 Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>G-Protein#P01085;Oxytocin receptor mediated signaling pathway#P04391>G-Protein#P04534;Cortocotropin releasing factor receptor signaling pathway#P04380>G-Protein#P04458;Opioid proopiomelanocortin pathway#P05917>G-protein#P06012;5HT4 type receptor mediated signaling pathway#P04376>G-protein#P04430;Metabotropic glutamate receptor group III pathway#P00039>G-Protein#P01045;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>G-Protein#P01073;Enkephalin release#P05913>G-Protein (s)#P05977;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Gbetagamma#P00836;Angiotensin II-stimulated signaling through G proteins and beta-arrestin#P05911>Ggamma#P05929;Enkephalin release#P05913>G-Protein (i)#P05974;5HT2 type receptor mediated signaling pathway#P04374>G-protein#P04416;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Ggamma#P00751;Thyrotropin-releasing hormone receptor signaling pathway#P04394>G-Protein#P04584;5HT1 type receptor mediated signaling pathway#P04373>G-protein#P04408;GABA-B receptor II signaling#P05731>Ggamma#P05754;Histamine H1 receptor mediated signaling pathway#P04385>G-Protein#P04488;Opioid proenkephalin pathway#P05915>G-protein#P05994;Beta2 adrenergic receptor signaling pathway#P04378>G-Protein#P04443;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Ggamma#P00721;Dopamine receptor mediated signaling pathway#P05912>Ggamma#P05967;Histamine H2 receptor mediated signaling pathway#P04386>G-Protein#P04490;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GIRK#P00743;Endogenous cannabinoid signaling#P05730>Ggamma#P05744;Wnt signaling pathway#P00057>Ggamma#P01465;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Ggamma#P00726;Metabotropic glutamate receptor group II pathway#P00040>G-protein#P01047;Beta3 adrenergic receptor signaling pathway#P04379>G-Protein#P04448;Opioid prodynorphin pathway#P05916>G-protein#P06002;Beta1 adrenergic receptor signaling pathway#P04377>G-Protein#P04436 HUMAN|HGNC=20692|UniProtKB=Q8IWU9 Q8IWU9 TPH2 PTHR11473:SF16 AROMATIC AMINO ACID HYDROXYLASE TRYPTOPHAN 5-HYDROXYLASE 2 oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;monooxygenase activity#GO:0004497;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705 metabolic process#GO:0008152;serotonin metabolic process#GO:0042428;phenol-containing compound metabolic process#GO:0018958;indole-containing compound metabolic process#GO:0042430;cellular process#GO:0009987;phenol-containing compound biosynthetic process#GO:0046189;biosynthetic process#GO:0009058;serotonin biosynthetic process#GO:0042427 neuron projection#GO:0043005;cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 5-Hydroxytryptamine biosynthesis#P04371>Tryptophan hydroxylase#P04399 HUMAN|HGNC=16289|UniProtKB=Q9BZY9 Q9BZY9 TRIM31 PTHR24103:SF87 E3 UBIQUITIN-PROTEIN LIGASE TRIM E3 UBIQUITIN-PROTEIN LIGASE TRIM31 catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787 innate immune response#GO:0045087;response to external stimulus#GO:0009605;defense response#GO:0006952;immune system process#GO:0002376;response to stimulus#GO:0050896;defense response to other organism#GO:0098542;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to other organism#GO:0051707;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;defense response to symbiont#GO:0140546;immune response#GO:0006955 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=19880|UniProtKB=Q9Y6C2 Q9Y6C2 EMILIN1 PTHR15427:SF1 EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER EMILIN-1 protein binding#GO:0005515;structural molecule activity#GO:0005198;binding#GO:0005488;extracellular matrix structural constituent#GO:0005201;cell adhesion molecule binding#GO:0050839;cell adhesion mediator activity#GO:0098631 positive regulation of multicellular organismal process#GO:0051240;regulation of multicellular organismal development#GO:2000026;positive regulation of cell adhesion#GO:0045785;positive regulation of cell-substrate adhesion#GO:0010811;regulation of biological process#GO:0050789;positive regulation of angiogenesis#GO:0045766;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;cell adhesion#GO:0007155;regulation of angiogenesis#GO:0045765;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;regulation of cell-substrate adhesion#GO:0010810;regulation of cell adhesion#GO:0030155;cell adhesion mediated by integrin#GO:0033627;positive regulation of developmental process#GO:0051094;regulation of vasculature development#GO:1901342;regulation of anatomical structure morphogenesis#GO:0022603 scaffold/adaptor protein#PC00226 HUMAN|HGNC=21302|UniProtKB=Q693B1 Q693B1 KCTD11 PTHR14499:SF7 POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD11 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=21396|UniProtKB=Q8WTS1 Q8WTS1 ABHD5 PTHR42886:SF34 RE40534P-RELATED 1-ACYLGLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE ABHD5 carboxylic ester hydrolase activity#GO:0052689;lipase activity#GO:0016298;acyltransferase activity#GO:0016746;hydrolase activity#GO:0016787;phospholipase activity#GO:0120569;hydrolase activity, acting on ester bonds#GO:0016788;transferase activity#GO:0016740;catalytic activity#GO:0003824;glycerophospholipase activity#GO:0004620;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 lipid biosynthetic process#GO:0008610;glycerophospholipid metabolic process#GO:0006650;biological regulation#GO:0065007;biosynthetic process#GO:0009058;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of catabolic process#GO:0009896;regulation of catabolic process#GO:0009894;metabolic process#GO:0008152;chemical homeostasis#GO:0048878;lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474;regulation of cellular process#GO:0050794;phospholipid biosynthetic process#GO:0008654;glycerolipid metabolic process#GO:0046486;phospholipid metabolic process#GO:0006644;homeostatic process#GO:0042592;primary metabolic process#GO:0044238;lipid homeostasis#GO:0055088;phosphorus metabolic process#GO:0006793;regulation of lipid catabolic process#GO:0050994;regulation of biological process#GO:0050789;organophosphate biosynthetic process#GO:0090407;positive regulation of metabolic process#GO:0009893;regulation of lipid metabolic process#GO:0019216 intracellular anatomical structure#GO:0005622;lipid droplet#GO:0005811;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;membraneless organelle#GO:0043228;organelle#GO:0043226;intracellular organelle#GO:0043229 HUMAN|HGNC=2316|UniProtKB=O75131 O75131 CPNE3 PTHR10857:SF22 COPINE COPINE-3 receptor tyrosine kinase binding#GO:0030971;phospholipid binding#GO:0005543;lipid binding#GO:0008289;protein binding#GO:0005515;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;kinase binding#GO:0019900;binding#GO:0005488;signaling receptor binding#GO:0005102;protein tyrosine kinase binding#GO:1990782 cell communication#GO:0007154;response to calcium ion#GO:0051592;enzyme-linked receptor protein signaling pathway#GO:0007167;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cellular response to chemical stimulus#GO:0070887;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to metal ion#GO:0010038;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;response to chemical#GO:0042221;signal transduction#GO:0007165;ERBB signaling pathway#GO:0038127;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 calcium-binding protein#PC00060 HUMAN|HGNC=13717|UniProtKB=Q9UJA9 Q9UJA9 ENPP5 PTHR10151:SF125 ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE ECTONUCLEOTIDE PYROPHOSPHATASE_PHOSPHODIESTERASE FAMILY MEMBER 5 hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HUMAN|HGNC=28932|UniProtKB=Q14CN4 Q14CN4 KRT72 PTHR45616:SF2 GATA-TYPE DOMAIN-CONTAINING PROTEIN KERATIN, TYPE II CYTOSKELETAL 72 structural molecule activity#GO:0005198 developmental process#GO:0032502;epidermis development#GO:0008544;cellular component organization or biogenesis#GO:0071840;animal organ development#GO:0048513;cellular developmental process#GO:0048869;cellular process#GO:0009987;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;skin development#GO:0043588;epithelium development#GO:0060429;tissue development#GO:0009888;epidermal cell differentiation#GO:0009913;multicellular organismal process#GO:0032501;epithelial cell differentiation#GO:0030855;intermediate filament organization#GO:0045109;intermediate filament-based process#GO:0045103;keratinocyte differentiation#GO:0030216;animal gross anatomical part developmental process#GO:0160108;supramolecular fiber organization#GO:0097435;anatomical structure development#GO:0048856;cellular component organization#GO:0016043;cell differentiation#GO:0030154;intermediate filament cytoskeleton organization#GO:0045104 membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;intracellular anatomical structure#GO:0005622;intermediate filament#GO:0005882;supramolecular fiber#GO:0099512;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232 HUMAN|HGNC=21591|UniProtKB=Q96LR4 Q96LR4 TAFA4 PTHR31770:SF11 CHEMOKINE-LIKE PROTEIN TAFA FAMILY MEMBER CHEMOKINE-LIKE PROTEIN TAFA-4 molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018 cellular process#GO:0009987;cell migration#GO:0016477;response to chemical#GO:0042221;taxis#GO:0042330;transport#GO:0006810;phagocytosis#GO:0006909;leukocyte migration#GO:0050900;leukocyte chemotaxis#GO:0030595;response to external stimulus#GO:0009605;myeloid leukocyte migration#GO:0097529;establishment of localization#GO:0051234;import into cell#GO:0098657;cellular response to stimulus#GO:0051716;locomotion#GO:0040011;cell motility#GO:0048870;endocytosis#GO:0006897;response to stimulus#GO:0050896;chemotaxis#GO:0006935;mononuclear cell migration#GO:0071674;cellular response to chemical stimulus#GO:0070887;immune system process#GO:0002376;cell chemotaxis#GO:0060326;macrophage chemotaxis#GO:0048246;localization#GO:0051179 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 cytokine#PC00083;chemokine#PC00074 HUMAN|HGNC=1343|UniProtKB=O43734 O43734 TRAF3IP2 PTHR34257:SF2 ADAPTER PROTEIN CIKS E3 UBIQUITIN LIGASE TRAF3IP2 regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;response to stimulus#GO:0050896;regulation of cell communication#GO:0010646;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789;positive regulation of signaling#GO:0023056;regulation of intracellular signal transduction#GO:1902531;immune system process#GO:0002376;regulation of signaling#GO:0023051;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of canonical NF-kappaB signal transduction#GO:0043122;immune response#GO:0006955;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of canonical NF-kappaB signal transduction#GO:0043123;humoral immune response#GO:0006959;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533 scaffold/adaptor protein#PC00226 HUMAN|HGNC=2945|UniProtKB=Q0VDD8 Q0VDD8 DNAH14 PTHR10676:SF356 DYNEIN HEAVY CHAIN FAMILY PROTEIN DYNEIN AXONEMAL HEAVY CHAIN 14 microtubule motor activity#GO:0003777;protein binding#GO:0005515;ATP-dependent activity#GO:0140657;binding#GO:0005488;polypeptide conformation or assembly isomerase activity#GO:0120544;isomerase activity#GO:0016853;cytoskeletal motor activity#GO:0003774;macromolecular conformation isomerase activity#GO:0120543;catalytic activity#GO:0003824 cilium movement involved in cell motility#GO:0060294;cellular process#GO:0009987;microtubule-based movement#GO:0007018;cell motility#GO:0048870;cilium or flagellum-dependent cell motility#GO:0001539;cilium movement#GO:0003341;cilium-dependent cell motility#GO:0060285;microtubule-based process#GO:0007017 cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;motile cilium#GO:0031514;organelle#GO:0043226;cellular anatomical structure#GO:0110165;dynein complex#GO:0030286;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cilium#GO:0005929;catalytic complex#GO:1902494;9+2 motile cilium#GO:0097729;intracellular organelle#GO:0043229;intracellular membraneless organelle#GO:0043232;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=10589|UniProtKB=O60939 O60939 SCN2B PTHR13869:SF3 MYELIN P0 RELATED SODIUM CHANNEL REGULATORY SUBUNIT BETA-2 molecular function regulator activity#GO:0098772;channel regulator activity#GO:0016247;ion channel regulator activity#GO:0099106;transporter regulator activity#GO:0141108 regulation of biological quality#GO:0065008;cardiac muscle contraction#GO:0060048;actin filament-based process#GO:0030029;circulatory system process#GO:0003013;membrane depolarization#GO:0051899;striated muscle contraction#GO:0006941;regulation of heart contraction#GO:0008016;actin-mediated cell contraction#GO:0070252;action potential#GO:0001508;regulation of biological process#GO:0050789;muscle system process#GO:0003012;heart process#GO:0003015;heart contraction#GO:0060047;system process#GO:0003008;cardiac muscle cell contraction#GO:0086003;regulation of membrane potential#GO:0042391;muscle contraction#GO:0006936;regulation of system process#GO:0044057;biological regulation#GO:0065007;regulation of multicellular organismal process#GO:0051239;blood circulation#GO:0008015;cardiac muscle cell action potential involved in contraction#GO:0086002;multicellular organismal process#GO:0032501;actin filament-based movement#GO:0030048;cellular process#GO:0009987 transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;sodium channel complex#GO:0034706;cation channel complex#GO:0034703;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;plasma membrane#GO:0005886;membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797 myelin protein#PC00161 HUMAN|HGNC=8694|UniProtKB=Q9Y5E1 Q9Y5E1 PCDHB9 PTHR24028:SF128 CADHERIN-87A PROTOCADHERIN BETA-9 cell adhesion#GO:0007155;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HUMAN|HGNC=23657|UniProtKB=Q9Y223 Q9Y223 GNE PTHR18964:SF176 ROK (REPRESSOR, ORF, KINASE) FAMILY BIFUNCTIONAL UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE_N-ACETYLMANNOSAMINE KINASE isomerase activity#GO:0016853;carbohydrate kinase activity#GO:0019200;catalytic activity#GO:0003824;transferase activity#GO:0016740;racemase and epimerase activity#GO:0016854;racemase and epimerase activity, acting on carbohydrates and derivatives#GO:0016857;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773 winged helix/forkhead transcription factor#PC00246 HUMAN|HGNC=28459|UniProtKB=Q71RG4 Q71RG4 TMUB2 PTHR14557:SF4 PROTEIN C7ORF21 TRANSMEMBRANE AND UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN 2 macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;response to stress#GO:0006950;proteasomal protein catabolic process#GO:0010498;response to chemical#GO:0042221;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;response to endoplasmic reticulum stress#GO:0034976;ERAD pathway#GO:0036503;protein metabolic process#GO:0019538;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;catabolic process#GO:0009056 HUMAN|HGNC=22393|UniProtKB=Q76B58 Q76B58 BRINP3 PTHR15564:SF2 MACPF DOMAIN-CONTAINING PROTEIN BMP_RETINOIC ACID-INDUCIBLE NEURAL-SPECIFIC PROTEIN 3 cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987;nervous system development#GO:0007399;response to chemical#GO:0042221;response to lipid#GO:0033993;cellular response to lipid#GO:0071396;neuron differentiation#GO:0030182;multicellular organism development#GO:0007275;negative regulation of cell cycle#GO:0045786;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of cell cycle#GO:0051726;central nervous system development#GO:0007417;cell differentiation#GO:0030154;response to stimulus#GO:0050896;generation of neurons#GO:0048699;response to oxygen-containing compound#GO:1901700;cellular response to chemical stimulus#GO:0070887;animal gross anatomical part developmental process#GO:0160108;negative regulation of mitotic cell cycle#GO:0045930;regulation of mitotic cell cycle#GO:0007346;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;developmental process#GO:0032502;central nervous system neuron differentiation#GO:0021953;negative regulation of cellular process#GO:0048523;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;system development#GO:0048731;anatomical structure development#GO:0048856 neuron projection#GO:0043005;cell body#GO:0044297;neuronal cell body#GO:0043025;somatodendritic compartment#GO:0036477;cell projection#GO:0042995;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165;dendritic tree#GO:0097447;dendrite#GO:0030425;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=18986|UniProtKB=Q9HCG7 Q9HCG7 GBA2 PTHR12654:SF33 BILE ACID BETA-GLUCOSIDASE-RELATED NON-LYSOSOMAL GLUCOSYLCERAMIDASE glucosidase activity#GO:0015926;beta-glucosidase activity#GO:0008422;catalytic activity#GO:0003824;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798 anatomical structure development#GO:0048856;multicellular organism development#GO:0007275;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502;multicellular organismal process#GO:0032501;central nervous system development#GO:0007417;nervous system development#GO:0007399 hydrolase#PC00121;glucosidase#PC00108 HUMAN|HGNC=25322|UniProtKB=Q8N999 Q8N999 RLIG1 PTHR31219:SF2 CHROMOSOME 28 C12ORF29 HOMOLOG RNA LIGASE 1 HUMAN|HGNC=13326|UniProtKB=P57058 P57058 HUNK PTHR24346:SF80 MAP/MICROTUBULE AFFINITY-REGULATING KINASE HORMONALLY UP-REGULATED NEU TUMOR-ASSOCIATED KINASE transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=9412|UniProtKB=Q05513 Q05513 PRKCZ PTHR24356:SF170 SERINE/THREONINE-PROTEIN KINASE PROTEIN KINASE C ZETA TYPE catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 cellular response to stimulus#GO:0051716;response to insulin#GO:0032868;establishment of cell polarity#GO:0030010;protein localization to plasma membrane#GO:0072659;cellular response to peptide hormone stimulus#GO:0071375;regulation of cellular process#GO:0050794;localization within membrane#GO:0051668;intracellular signal transduction#GO:0035556;response to nitrogen compound#GO:1901698;cell communication#GO:0007154;localization#GO:0051179;macromolecule localization#GO:0033036;response to peptide hormone#GO:0043434;biological regulation#GO:0065007;cellular response to nitrogen compound#GO:1901699;cellular response to insulin stimulus#GO:0032869;intracellular protein localization#GO:0008104;regulation of biological process#GO:0050789;protein localization to membrane#GO:0072657;response to endogenous stimulus#GO:0009719;signaling#GO:0023052;cellular response to hormone stimulus#GO:0032870;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;response to oxygen-containing compound#GO:1901700;cellular response to chemical stimulus#GO:0070887;establishment or maintenance of cell polarity#GO:0007163;cellular localization#GO:0051641;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;response to hormone#GO:0009725;response to chemical#GO:0042221;protein localization to cell periphery#GO:1990778 non-receptor serine/threonine protein kinase#PC00167 Endothelin signaling pathway#P00019>PKC#P00568;Oxytocin receptor mediated signaling pathway#P04391>PKC#P04533;Wnt signaling pathway#P00057>Protein Kinase C#P01458;Thyrotropin-releasing hormone receptor signaling pathway#P04394>PKC#P04583;FGF signaling pathway#P00021>PKC#P00648;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PKCzeta#P00829;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PKC#P00861;VEGF signaling pathway#P00056>PKC#P01425;Angiogenesis#P00005>PKC#P00219;Histamine H1 receptor mediated signaling pathway#P04385>PKC#P04487;EGF receptor signaling pathway#P00018>PKC#P00565;5HT2 type receptor mediated signaling pathway#P04374>PKC#P04420;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>PKC#P01074;Gonadotropin-releasing hormone receptor pathway#P06664>PKCs#P06733;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>PKC#P00745;Alzheimer disease-amyloid secretase pathway#P00003>PKC#P00109 HUMAN|HGNC=10959|UniProtKB=Q9Y6L6 Q9Y6L6 SLCO1B1 PTHR11388:SF89 ORGANIC ANION TRANSPORTER SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 1B1 transporter activity#GO:0005215;carboxylic acid transmembrane transporter activity#GO:0046943;transmembrane transporter activity#GO:0022857;secondary active transmembrane transporter activity#GO:0015291;bile acid transmembrane transporter activity#GO:0015125;active transmembrane transporter activity#GO:0022804 cellular process#GO:0009987;macromolecule localization#GO:0033036;lipid transport#GO:0006869;carboxylic acid transport#GO:0046942;transport#GO:0006810;organic acid transport#GO:0015849;bile acid and bile salt transport#GO:0015721;lipid localization#GO:0010876;monocarboxylic acid transport#GO:0015718;organic hydroxy compound transport#GO:0015850;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179 cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;plasma membrane#GO:0005886;membrane#GO:0016020;basal part of cell#GO:0045178;basolateral plasma membrane#GO:0016323;cell periphery#GO:0071944;basal plasma membrane#GO:0009925 transporter#PC00227 HUMAN|HGNC=4887|UniProtKB=Q6ZVN8 Q6ZVN8 HJV PTHR31428:SF3 RGM DOMAIN FAMILY MEMBER DRAG-1 HEMOJUVELIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;coreceptor activity#GO:0015026 transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;cell surface receptor signaling pathway#GO:0007166;response to BMP#GO:0071772;cellular response to BMP stimulus#GO:0071773;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;response to growth factor#GO:0070848;cellular response to endogenous stimulus#GO:0071495;signaling#GO:0023052;response to endogenous stimulus#GO:0009719;cellular response to stimulus#GO:0051716;BMP signaling pathway#GO:0030509;regulation of biological process#GO:0050789;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cellular response to growth factor stimulus#GO:0071363 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;signaling receptor complex#GO:0043235 HUMAN|HGNC=17082|UniProtKB=Q15049 Q15049 MLC1 PTHR17597:SF0 MEMBRANE PROTEIN MLC1 MEMBRANE PROTEIN MLC1 biological regulation#GO:0065007;regulation of response to stress#GO:0080134;regulation of biological process#GO:0050789;regulation of response to stimulus#GO:0048583 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;membrane#GO:0016020;vesicle#GO:0031982;cell periphery#GO:0071944;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 HUMAN|HGNC=21356|UniProtKB=Q6QEF8 Q6QEF8 CORO6 PTHR10856:SF23 CORONIN CORONIN-6 protein-containing complex binding#GO:0044877;protein binding#GO:0005515;actin filament binding#GO:0051015;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;binding#GO:0005488 cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;cell migration#GO:0016477;cell motility#GO:0048870;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029 supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;actin cytoskeleton#GO:0015629;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;actin filament#GO:0005884;supramolecular complex#GO:0099080;lamellipodium#GO:0030027;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;cell leading edge#GO:0031252;membrane#GO:0016020;cell periphery#GO:0071944 cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HUMAN|HGNC=17637|UniProtKB=Q96FX8 Q96FX8 PERP PTHR14399:SF4 P53-INDUCED PROTEIN RELATED P53 APOPTOSIS EFFECTOR RELATED TO PMP-22 cell-cell adhesion#GO:0098609;cellular process#GO:0009987;cell adhesion#GO:0007155 cell-cell junction#GO:0005911;anchoring junction#GO:0070161;cellular anatomical structure#GO:0110165;cell junction#GO:0030054 p53 pathway#P00059>PERP#G01565 HUMAN|HGNC=29306|UniProtKB=Q9P1Z2 Q9P1Z2 CALCOCO1 PTHR31915:SF5 SKICH DOMAIN-CONTAINING PROTEIN CALCIUM-BINDING AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1 transcription coactivator activity#GO:0003713;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of DNA-templated transcription#GO:0006355;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789 HUMAN|HGNC=37227|UniProtKB=C9JR72 C9JR72 KBTBD13 PTHR46375:SF3 KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 13-RELATED KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 13 regulation of muscle system process#GO:0090257;regulation of biological process#GO:0050789;muscle system process#GO:0003012;multicellular organismal process#GO:0032501;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;regulation of system process#GO:0044057;regulation of muscle contraction#GO:0006937;system process#GO:0003008 HUMAN|HGNC=17287|UniProtKB=Q9H5I1 Q9H5I1 SUV39H2 PTHR46223:SF2 HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H2 transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein methyltransferase activity#GO:0008276;catalytic activity, acting on a protein#GO:0140096;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;N-methyltransferase activity#GO:0008170;histone methyltransferase activity#GO:0042054;protein-lysine N-methyltransferase activity#GO:0016279;histone H3 methyltransferase activity#GO:0140938;histone modifying activity#GO:0140993;lysine N-methyltransferase activity#GO:0016278 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 histone modifying enzyme#PC00261;chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=25783|UniProtKB=Q14CX7 Q14CX7 NAA25 PTHR22767:SF3 N-TERMINAL ACETYLTRANSFERASE-RELATED N-ALPHA-ACETYLTRANSFERASE 25, NATB AUXILIARY SUBUNIT enzyme activator activity#GO:0008047;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234 cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010 intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;acetyltransferase complex#GO:1902493;protein acetyltransferase complex#GO:0031248;catalytic complex#GO:1902494;transferase complex#GO:1990234;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 acetyltransferase#PC00038 HUMAN|HGNC=20487|UniProtKB=Q6NXP6 Q6NXP6 NOXRED1 PTHR11645:SF58 PYRROLINE-5-CARBOXYLATE REDUCTASE NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 1 oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 small molecule biosynthetic process#GO:0044283;amino acid biosynthetic process#GO:0008652;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;proteinogenic amino acid biosynthetic process#GO:0170038;carboxylic acid biosynthetic process#GO:0046394;cellular process#GO:0009987;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;amino acid metabolic process#GO:0006520;biosynthetic process#GO:0009058;proteinogenic amino acid metabolic process#GO:0170039;small molecule metabolic process#GO:0044281 reductase#PC00198;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=25508|UniProtKB=Q9H6D3 Q9H6D3 XKR8 PTHR16024:SF8 XK-RELATED PROTEIN XK-RELATED PROTEIN 8 cellular process#GO:0009987;endomembrane system organization#GO:0010256;membrane invagination#GO:0010324;cellular component organization or biogenesis#GO:0071840;phagocytosis, engulfment#GO:0006911;apoptotic cell clearance#GO:0043277;import into cell#GO:0098657;execution phase of apoptosis#GO:0097194;apoptotic process#GO:0006915;cellular component organization#GO:0016043;endocytosis#GO:0006897;lipid localization#GO:0010876;regulation of biological quality#GO:0065008;plasma membrane organization#GO:0007009;macromolecule localization#GO:0033036;phospholipid translocation#GO:0045332;membrane organization#GO:0061024;phospholipid transport#GO:0015914;biological regulation#GO:0065007;lipid transport#GO:0006869;developmental process#GO:0032502;transport#GO:0006810;phagocytosis#GO:0006909;regulation of membrane lipid distribution#GO:0097035;establishment of localization#GO:0051234;cell death#GO:0008219;programmed cell death#GO:0012501;plasma membrane phospholipid scrambling#GO:0017121;lipid translocation#GO:0034204;organophosphate ester transport#GO:0015748;localization#GO:0051179;anatomical structure development#GO:0048856 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 secondary carrier transporter#PC00258 HUMAN|HGNC=49760|UniProtKB=A0A3B3IRV3 A0A3B3IRV3 MCTS2 PTHR22798:SF11 MCT-1 PROTEIN MALIGNANT T-CELL-AMPLIFIED SEQUENCE 2 translation factor activity#GO:0180051;translation initiation factor activity#GO:0003743 primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cytoplasmic translation#GO:0002181;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;biosynthetic process#GO:0009058;cytoplasmic translational initiation#GO:0002183;metabolic process#GO:0008152;translation#GO:0006412;translational initiation#GO:0006413;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 translation initiation factor#PC00224 HUMAN|HGNC=33795|UniProtKB=Q8N912 Q8N912 NRAC PTHR36868:SF1 NUTRITIONALLY-REGULATED ADIPOSE AND CARDIAC ENRICHED PROTEIN HOMOLOG NUTRITIONALLY-REGULATED ADIPOSE AND CARDIAC ENRICHED PROTEIN HOMOLOG HUMAN|HGNC=4901|UniProtKB=Q03014 Q03014 HHEX PTHR24324:SF5 HOMEOBOX PROTEIN HHEX HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 developmental process#GO:0032502;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=29389|UniProtKB=A7MD48 A7MD48 SRRM4 PTHR34755:SF1 SERINE/ARGININE REPETITIVE MATRIX PROTEIN 3-RELATED SERINE_ARGININE REPETITIVE MATRIX PROTEIN 4 nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;RNA binding#GO:0003723 anatomical structure development#GO:0048856;system development#GO:0048731;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;anatomical structure maturation#GO:0071695;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;RNA biosynthetic process#GO:0032774;developmental process#GO:0032502;cell maturation#GO:0048469;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;macromolecule biosynthetic process#GO:0009059;developmental maturation#GO:0021700;multicellular organismal process#GO:0032501;regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;neuron development#GO:0048666;regulation of biological process#GO:0050789;cell differentiation#GO:0030154;mRNA metabolic process#GO:0016071;cell development#GO:0048468;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;neuron differentiation#GO:0030182;multicellular organism development#GO:0007275;mRNA processing#GO:0006397;cellular process#GO:0009987;gene expression#GO:0010467;RNA processing#GO:0006396;nervous system development#GO:0007399 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=28289|UniProtKB=Q96F63 Q96F63 CCDC97 PTHR31840:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 97 COILED-COIL DOMAIN-CONTAINING PROTEIN 97 HUMAN|HGNC=21237|UniProtKB=Q9BRT2 Q9BRT2 UQCC2 PTHR34260:SF1 UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX ASSEMBLY FACTOR 2 UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX ASSEMBLY FACTOR 2 cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;cellular component assembly#GO:0022607;mitochondrial respiratory chain complex assembly#GO:0033108;mitochondrion organization#GO:0007005;mitochondrial respiratory chain complex III assembly#GO:0034551;cytochrome complex assembly#GO:0017004;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;mitochondrion#GO:0005739 chaperone#PC00072 HUMAN|HGNC=30536|UniProtKB=Q96GE9 Q96GE9 DMAC1 PTHR36469:SF1 DISTAL MEMBRANE-ARM ASSEMBLY COMPLEX PROTEIN 1 DISTAL MEMBRANE-ARM ASSEMBLY COMPLEX PROTEIN 1 NADH dehydrogenase complex assembly#GO:0010257;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;mitochondrial respiratory chain complex I assembly#GO:0032981;cellular component organization#GO:0016043;mitochondrial respiratory chain complex assembly#GO:0033108;mitochondrion organization#GO:0007005;cellular component assembly#GO:0022607 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866 HUMAN|HGNC=15472|UniProtKB=O94788 O94788 ALDH1A2 PTHR11699:SF102 ALDEHYDE DEHYDROGENASE-RELATED RETINAL DEHYDROGENASE 2 oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the aldehyde or oxo group of donors#GO:0016903;oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor#GO:0016620;aldehyde dehydrogenase (NAD+) activity#GO:0004029 regulation of biological quality#GO:0065008;isoprenoid metabolic process#GO:0006720;terpenoid metabolic process#GO:0006721;isoprenoid biosynthetic process#GO:0008299;oxoacid metabolic process#GO:0043436;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;regulation of hormone levels#GO:0010817;carboxylic acid biosynthetic process#GO:0046394;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;diterpenoid metabolic process#GO:0016101;retinoid metabolic process#GO:0001523;monocarboxylic acid biosynthetic process#GO:0072330;diterpenoid biosynthetic process#GO:0016102;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;biological regulation#GO:0065007;biosynthetic process#GO:0009058;aldehyde catabolic process#GO:0046185;hormone metabolic process#GO:0042445;terpenoid biosynthetic process#GO:0016114;lipid biosynthetic process#GO:0008610;cellular process#GO:0009987;aldehyde metabolic process#GO:0006081 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 5-Hydroxytryptamine degredation#P04372>Aldehyde Dehydrogenase#P04402 HUMAN|HGNC=6006|UniProtKB=Q9HBE5 Q9HBE5 IL21R PTHR23037:SF7 CYTOKINE RECEPTOR INTERLEUKIN-21 RECEPTOR molecular transducer activity#GO:0060089;immune receptor activity#GO:0140375;signaling receptor activity#GO:0038023;cytokine receptor activity#GO:0004896;transmembrane signaling receptor activity#GO:0004888 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cellular response to cytokine stimulus#GO:0071345;signal transduction#GO:0007165;regulation of biological process#GO:0050789;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to chemical#GO:0042221;response to stimulus#GO:0050896;response to cytokine#GO:0034097;cell surface receptor signaling pathway#GO:0007166;cytokine-mediated signaling pathway#GO:0019221;response to peptide#GO:1901652;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell surface#GO:0009986;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=1583|UniProtKB=P30279 P30279 CCND2 PTHR10177:SF66 CYCLINS G1_S-SPECIFIC CYCLIN-D2 enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;cyclin-dependent protein kinase regulator activity#GO:0019914;protein kinase regulator activity#GO:0019887;cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538 biological regulation#GO:0065007;regulation of cell cycle process#GO:0010564;positive regulation of cell cycle#GO:0045787;cell cycle G1/S phase transition#GO:0044843;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of mitotic cell cycle#GO:0007346;mitotic cell cycle process#GO:1903047;positive regulation of mitotic cell cycle#GO:0045931;positive regulation of cell cycle G1/S phase transition#GO:1902808;G1/S transition of mitotic cell cycle#GO:0000082;regulation of cell cycle G1/S phase transition#GO:1902806;regulation of cell cycle#GO:0051726;mitotic cell cycle#GO:0000278;cell cycle phase transition#GO:0044770;regulation of cellular process#GO:0050794;positive regulation of cell cycle process#GO:0090068;regulation of biological process#GO:0050789;cell cycle process#GO:0022402;regulation of cell cycle phase transition#GO:1901987;cell cycle#GO:0007049;regulation of mitotic cell cycle phase transition#GO:1901990;regulation of G1/S transition of mitotic cell cycle#GO:2000045;mitotic cell cycle phase transition#GO:0044772 cytoplasm#GO:0005737;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;microtubule cytoskeleton#GO:0015630;protein kinase complex#GO:1902911;membraneless organelle#GO:0043228;transferase complex#GO:1990234;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695 kinase activator#PC00138 PI3 kinase pathway#P00048>Cyclin d#G01546;Cell cycle#P00013>Cyclin D#P00484 HUMAN|HGNC=4006|UniProtKB=P04066 P04066 FUCA1 PTHR10030:SF37 ALPHA-L-FUCOSIDASE TISSUE ALPHA-L-FUCOSIDASE hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824 metabolic process#GO:0008152;monosaccharide metabolic process#GO:0005996;primary metabolic process#GO:0044238;hexose metabolic process#GO:0019318;glycosyl compound catabolic process#GO:1901658;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;carbohydrate metabolic process#GO:0005975;carbohydrate derivative catabolic process#GO:1901136 hydrolase#PC00121;glycosidase#PC00110 HUMAN|HGNC=1192|UniProtKB=Q9H2W6 Q9H2W6 MRPL46 PTHR13124:SF12 39S RIBOSOMAL PROTEIN L46, MITOCHONDRIAL PRECURSOR-RELATED LARGE RIBOSOMAL SUBUNIT PROTEIN ML46 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 organelle lumen#GO:0043233;ribosome#GO:0005840;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;large ribosomal subunit#GO:0015934;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;mitochondrial ribosome#GO:0005761;organellar ribosome#GO:0000313;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;membraneless organelle#GO:0043228;mitochondrial large ribosomal subunit#GO:0005762 ribosomal protein#PC00202 HUMAN|HGNC=891|UniProtKB=Q9Y679 Q9Y679 AUP1 PTHR15486:SF103 ANCIENT UBIQUITOUS PROTEIN LIPID DROPLET-REGULATING VLDL ASSEMBLY FACTOR AUP1 proteasomal protein catabolic process#GO:0010498;response to chemical#GO:0042221;cellular process#GO:0009987;response to stress#GO:0006950;macromolecule metabolic process#GO:0043170;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;catabolic process#GO:0009056;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;ERAD pathway#GO:0036503;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;response to endoplasmic reticulum stress#GO:0034976 membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HUMAN|HGNC=8172|UniProtKB=Q9Y4A9 Q9Y4A9 OR10H1 PTHR26453:SF712 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 10H1-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 sensory perception#GO:0007600;nervous system process#GO:0050877;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;system process#GO:0003008;detection of chemical stimulus#GO:0009593;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;response to stimulus#GO:0050896;response to chemical#GO:0042221;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=777|UniProtKB=Q15911 Q15911 ZFHX3 PTHR45891:SF4 ZINC FINGER HOMEOBOX PROTEIN ZINC FINGER HOMEOBOX PROTEIN 3 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=15448|UniProtKB=O00461 O00461 GOLIM4 PTHR22909:SF22 GOLGI INTEGRAL MEMBRANE PROTEIN 4 GOLGI INTEGRAL MEMBRANE PROTEIN 4 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020 HUMAN|HGNC=16379|UniProtKB=Q8IYM9 Q8IYM9 TRIM22 PTHR24103:SF650 E3 UBIQUITIN-PROTEIN LIGASE TRIM E3 UBIQUITIN-PROTEIN LIGASE TRIM22 catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein binding#GO:0005515;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;kinase binding#GO:0019900;binding#GO:0005488;protein kinase binding#GO:0019901;ubiquitin-like protein transferase activity#GO:0019787;enzyme binding#GO:0019899;ubiquitin protein ligase activity#GO:0061630 regulation of protein localization#GO:0032880;positive regulation of metabolic process#GO:0009893;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;immune system process#GO:0002376;regulation of intracellular signal transduction#GO:1902531;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;regulation of autophagy#GO:0010506;regulation of localization#GO:0032879;positive regulation of canonical NF-kappaB signal transduction#GO:0043123;defense response to other organism#GO:0098542;positive regulation of biological process#GO:0048518;defense response to symbiont#GO:0140546;positive regulation of autophagy#GO:0010508;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;response to external biotic stimulus#GO:0043207;regulation of cell communication#GO:0010646;regulation of macromolecule metabolic process#GO:0060255;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;positive regulation of signal transduction#GO:0009967;response to external stimulus#GO:0009605;regulation of catabolic process#GO:0009894;defense response#GO:0006952;regulation of gene expression#GO:0010468;positive regulation of catabolic process#GO:0009896;regulation of biosynthetic process#GO:0009889;innate immune response#GO:0045087;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;response to other organism#GO:0051707;positive regulation of response to stimulus#GO:0048584;immune response#GO:0006955;positive regulation of cellular process#GO:0048522;regulation of canonical NF-kappaB signal transduction#GO:0043122;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=20817|UniProtKB=Q86V71 Q86V71 ZNF429 PTHR24377:SF938 IP01015P-RELATED ZINC FINGER PROTEIN 429-RELATED sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=9543|UniProtKB=P28072 P28072 PSMB6 PTHR11599:SF46 PROTEASOME SUBUNIT ALPHA/BETA PROTEASOME SUBUNIT BETA TYPE-6 peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511 catalytic complex#GO:1902494;intracellular organelle#GO:0043229;endopeptidase complex#GO:1905369;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;proteasome complex#GO:0000502;nucleus#GO:0005634;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;peptidase complex#GO:1905368 protease#PC00190;protein modifying enzyme#PC00260 HUMAN|HGNC=29845|UniProtKB=Q6PP77 Q6PP77 XKRX PTHR14297:SF4 MEMBRANE TRANSPORT PROTEIN XK FAMILY MEMBER XK-RELATED PROTEIN 2 HUMAN|HGNC=3146|UniProtKB=P42892 P42892 ECE1 PTHR11733:SF130 ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED ENDOTHELIN-CONVERTING ENZYME 1 metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 regulation of biological quality#GO:0065008;signaling receptor ligand precursor processing#GO:0140448;protein metabolic process#GO:0019538;proteolysis#GO:0006508;regulation of hormone levels#GO:0010817;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;biosynthetic process#GO:0009058;biological regulation#GO:0065007;hormone metabolic process#GO:0042445;gene expression#GO:0010467;protein maturation#GO:0051604;cellular process#GO:0009987;protein processing#GO:0016485;peptide hormone processing#GO:0016486;macromolecule biosynthetic process#GO:0009059 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 metalloprotease#PC00153;protease#PC00190 Endothelin signaling pathway#P00019>ECE1-3#P00585 HUMAN|HGNC=19199|UniProtKB=Q6W0C5 Q6W0C5 DPPA3 PTHR31577:SF2 DEVELOPMENTAL PLURIPOTENCY-ASSOCIATED PROTEIN 3-RELATED DEVELOPMENTAL PLURIPOTENCY-ASSOCIATED PROTEIN 3 histone H3 reader activity#GO:0140006;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;histone H3K9me2/3 reader activity#GO:0062072;histone reader activity#GO:0140566;chromatin-protein adaptor activity#GO:0140463 anatomical structure development#GO:0048856;regulation of biological process#GO:0050789;cell division#GO:0051301;cellular component organization#GO:0016043;chromatin remodeling#GO:0006338;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;developmental process#GO:0032502;regulation of gene expression#GO:0010468;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;cellular process#GO:0009987;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;chromatin organization#GO:0006325;biological regulation#GO:0065007;embryo development#GO:0009790;multicellular organismal process#GO:0032501 membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;chromatin#GO:0000785;nucleus#GO:0005634 HUMAN|HGNC=17054|UniProtKB=Q9Y2H2 Q9Y2H2 INPP5F PTHR45662:SF8 PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1 PHOSPHATIDYLINOSITIDE 4-PHOSPHATASE SAC2 hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787 primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;phosphate-containing compound metabolic process#GO:0006796;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;phospholipid dephosphorylation#GO:0046839;regulation of cellular process#GO:0050794;glycerolipid metabolic process#GO:0046486;phospholipid metabolic process#GO:0006644;phosphatidylinositol dephosphorylation#GO:0046856;dephosphorylation#GO:0016311;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;glycerophospholipid metabolic process#GO:0006650;biological regulation#GO:0065007;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;phosphatidylinositol metabolic process#GO:0046488;lipid modification#GO:0030258;regulation of localization#GO:0032879;regulation of transport#GO:0051049 endocytic vesicle#GO:0030139;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;coated vesicle#GO:0030135;intracellular organelle#GO:0043229;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;clathrin-coated endocytic vesicle#GO:0045334;endoplasmic reticulum#GO:0005783;clathrin-coated vesicle#GO:0030136;cytoplasm#GO:0005737;endomembrane system#GO:0012505 hydrolase#PC00121;phosphatase#PC00181 HUMAN|HGNC=9392|UniProtKB=P31323 P31323 PRKAR2B PTHR11635:SF156 CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN CAMP-DEPENDENT PROTEIN KINASE TYPE II-BETA REGULATORY SUBUNIT ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;protein kinase A binding#GO:0051018;kinase regulator activity#GO:0019207;protein kinase regulator activity#GO:0019887;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;kinase inhibitor activity#GO:0019210;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;nucleoside phosphate binding#GO:1901265;kinase binding#GO:0019900;binding#GO:0005488;molecular function inhibitor activity#GO:0140678;protein binding#GO:0005515;enzyme regulator activity#GO:0030234;enzyme inhibitor activity#GO:0004857;molecular function regulator activity#GO:0098772;nucleotide binding#GO:0000166;protein kinase inhibitor activity#GO:0004860;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cell communication#GO:0007154 cytosol#GO:0005829;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;transferase complex#GO:1990234;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695;protein kinase complex#GO:1902911;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;serine/threonine protein kinase complex#GO:1902554 kinase modulator#PC00140;protein-binding activity modulator#PC00095 Beta2 adrenergic receptor signaling pathway#P04378>PKA#P04444;GABA-B receptor II signaling#P05731>PKA#P05752;Endothelin signaling pathway#P00019>PKA#P00570;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>PKA-r#P00700;Metabotropic glutamate receptor group II pathway#P00040>PKA#P01050;5HT1 type receptor mediated signaling pathway#P04373>PKA#P04403;Dopamine receptor mediated signaling pathway#P05912>PKA#P05946;Enkephalin release#P05913>PKA#P05972;Metabotropic glutamate receptor group III pathway#P00039>PKA#P01035;Beta1 adrenergic receptor signaling pathway#P04377>PKA#P04437;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>PKA#P01075;Transcription regulation by bZIP transcription factor#P00055>PKA#P01384;Hedgehog signaling pathway#P00025>PKA#P00682;Histamine H2 receptor mediated signaling pathway#P04386>PKA#P04491 HUMAN|HGNC=20322|UniProtKB=Q96T25 Q96T25 ZIC5 PTHR19818:SF69 ZINC FINGER PROTEIN ZIC AND GLI ZINC FINGER PROTEIN ZIC 5 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987 regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;central nervous system development#GO:0007417;regulation of transcription by RNA polymerase II#GO:0006357;animal gross anatomical part developmental process#GO:0160108;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;nervous system development#GO:0007399;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;developmental process#GO:0032502;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;multicellular organism development#GO:0007275 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=20738|UniProtKB=Q86TM6 Q86TM6 SYVN1 PTHR22763:SF196 RING ZINC FINGER PROTEIN E3 UBIQUITIN-PROTEIN LIGASE SYNOVIOLIN ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824 ERAD pathway#GO:0036503;protein metabolic process#GO:0019538;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;response to endoplasmic reticulum stress#GO:0034976;response to stimulus#GO:0050896;catabolic process#GO:0009056;cellular response to stimulus#GO:0051716;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;proteasomal protein catabolic process#GO:0010498;response to chemical#GO:0042221;cellular process#GO:0009987;response to stress#GO:0006950 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=14946|UniProtKB=Q9ULJ8 Q9ULJ8 PPP1R9A PTHR16154:SF22 NEURABIN NEURABIN-1 protein-containing complex binding#GO:0044877;protein-membrane adaptor activity#GO:0043495;protein binding#GO:0005515;actin filament binding#GO:0051015;actin binding#GO:0003779;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;cytoskeletal protein binding#GO:0008092;molecular adaptor activity#GO:0060090 intracellular signaling cassette#GO:0141124;nervous system development#GO:0007399;cytoskeleton organization#GO:0007010;cellular process#GO:0009987;signal transduction#GO:0007165;neuron projection development#GO:0031175;organelle organization#GO:0006996;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;neuron differentiation#GO:0030182;cell development#GO:0048468;signaling#GO:0023052;cell differentiation#GO:0030154;response to stimulus#GO:0050896;cell projection organization#GO:0030030;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;neuron development#GO:0048666;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;neurogenesis#GO:0022008;calcium-mediated signaling#GO:0019722;actin filament organization#GO:0007015;cellular developmental process#GO:0048869;developmental process#GO:0032502;regulation of cellular process#GO:0050794;actin cytoskeleton organization#GO:0030036;cellular response to stimulus#GO:0051716;intracellular signal transduction#GO:0035556;supramolecular fiber organization#GO:0097435;system development#GO:0048731;anatomical structure development#GO:0048856;cell communication#GO:0007154;actin filament-based process#GO:0030029 cytoskeleton#GO:0005856;cell junction#GO:0030054;membraneless organelle#GO:0043228;neuron projection#GO:0043005;cell periphery#GO:0071944;intracellular membraneless organelle#GO:0043232;somatodendritic compartment#GO:0036477;cytoplasm#GO:0005737;cortical actin cytoskeleton#GO:0030864;postsynaptic specialization#GO:0099572;neuron to neuron synapse#GO:0098984;dendritic tree#GO:0097447;intracellular organelle#GO:0043229;postsynaptic density#GO:0014069;filopodium#GO:0030175;dendrite#GO:0030425;intracellular anatomical structure#GO:0005622;cell cortex#GO:0005938;actin-based cell projection#GO:0098858;actin cytoskeleton#GO:0015629;cortical cytoskeleton#GO:0030863;postsynapse#GO:0098794;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;asymmetric synapse#GO:0032279;organelle#GO:0043226;cellular anatomical structure#GO:0110165;synapse#GO:0045202 HUMAN|HGNC=23526|UniProtKB=Q8NE86 Q8NE86 MCU PTHR13462:SF16 CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL passive transmembrane transporter activity#GO:0022803;calcium channel activity#GO:0005262;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261;active transmembrane transporter activity#GO:0022804;metal ion transmembrane transporter activity#GO:0046873;calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267 establishment of localization#GO:0051234;cellular homeostasis#GO:0019725;calcium ion transport#GO:0006816;intracellular calcium ion homeostasis#GO:0006874;intracellular chemical homeostasis#GO:0055082;transport#GO:0006810;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion homeostasis#GO:0050801;mitochondrial calcium ion transmembrane transport#GO:0006851;cellular process#GO:0009987;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;calcium ion homeostasis#GO:0055074;inorganic ion homeostasis#GO:0098771;mitochondrial calcium ion homeostasis#GO:0051560;homeostatic process#GO:0042592;metal ion transport#GO:0030001;calcium ion transmembrane transport#GO:0070588;intracellular monoatomic ion homeostasis#GO:0006873 transmembrane transporter complex#GO:1902495;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;membrane protein complex#GO:0098796;mitochondrion#GO:0005739;calcium channel complex#GO:0034704;transporter complex#GO:1990351;organelle membrane#GO:0031090;inner mitochondrial membrane protein complex#GO:0098800;cation channel complex#GO:0034703;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;mitochondrial protein-containing complex#GO:0098798;cytoplasm#GO:0005737;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrial membrane#GO:0031966 HUMAN|HGNC=19278|UniProtKB=Q9H1E1 Q9H1E1 RNASE7 PTHR11437:SF31 RIBONUCLEASE RIBONUCLEASE 7 catalytic activity, acting on RNA#GO:0140098;RNA nuclease activity#GO:0004540;nuclease activity#GO:0004518;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640 innate immune response#GO:0045087;defense response#GO:0006952;response to external stimulus#GO:0009605;defense response to other organism#GO:0098542;response to other organism#GO:0051707;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;immune response#GO:0006955;defense response to symbiont#GO:0140546;immune system process#GO:0002376;response to bacterium#GO:0009617;defense response to bacterium#GO:0042742;response to stimulus#GO:0050896;defense response to fungus#GO:0050832;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;defense response to Gram-negative bacterium#GO:0050829;defense response to Gram-positive bacterium#GO:0050830 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 RNA metabolism protein#PC00031;endoribonuclease#PC00094 HUMAN|HGNC=13608|UniProtKB=Q9UKT8 Q9UKT8 FBXW2 PTHR44436:SF1 F-BOX/WD REPEAT-CONTAINING PROTEIN 2 F-BOX_WD REPEAT-CONTAINING PROTEIN 2 HUMAN|HGNC=25153|UniProtKB=Q96EY5 Q96EY5 MVB12A PTHR31612:SF2 MULTIVESICULAR BODY SUBUNIT 12A MULTIVESICULAR BODY SUBUNIT 12A regulation of signaling#GO:0023051;lysosomal transport#GO:0007041;endosome to lysosome transport#GO:0008333;cellular localization#GO:0051641;localization#GO:0051179;regulation of biological process#GO:0050789;regulation of ERBB signaling pathway#GO:1901184;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of response to stimulus#GO:0048583;transport#GO:0006810;vacuolar transport#GO:0007034;macromolecule catabolic process#GO:0009057;intracellular transport#GO:0046907;metabolic process#GO:0008152;endosomal transport#GO:0016197;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;multivesicular body sorting pathway#GO:0071985;establishment of localization in cell#GO:0051649;regulation of epidermal growth factor receptor signaling pathway#GO:0042058;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;vesicle-mediated transport#GO:0016192;endosome transport via multivesicular body sorting pathway#GO:0032509 organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;ESCRT I complex#GO:0000813;membrane#GO:0016020;vesicle membrane#GO:0012506;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endosome membrane#GO:0010008;endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796 HUMAN|HGNC=5270|UniProtKB=P25685 P25685 DNAJB1 PTHR24078:SF568 DNAJ HOMOLOG SUBFAMILY C MEMBER DNAJ HOMOLOG SUBFAMILY B MEMBER 1 transcription regulator activity#GO:0140110;binding#GO:0005488;protein binding#GO:0005515;heat shock protein binding#GO:0031072;transcription coregulator activity#GO:0003712;protein-folding chaperone binding#GO:0051087;transcription corepressor activity#GO:0003714;Hsp70 protein binding#GO:0030544 negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;metabolic process#GO:0008152;gene expression#GO:0010467;protein maturation#GO:0051604;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of metabolic process#GO:0009892;protein folding#GO:0006457;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;biosynthetic process#GO:0009058;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;macromolecule biosynthetic process#GO:0009059;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;protein metabolic process#GO:0019538;regulation of DNA-templated transcription#GO:0006355;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;primary metabolic process#GO:0044238 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HUMAN|HGNC=2988|UniProtKB=Q92608 Q92608 DOCK2 PTHR45653:SF6 DEDICATOR OF CYTOKINESIS DEDICATOR OF CYTOKINESIS PROTEIN 2 guanyl-nucleotide exchange factor activity#GO:0005085;binding#GO:0005488;enzyme binding#GO:0019899;protein binding#GO:0005515;small GTPase binding#GO:0031267;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772 cell differentiation#GO:0030154;cell motility#GO:0048870;muscle structure development#GO:0061061;cell migration#GO:0016477;muscle cell differentiation#GO:0042692;cellular process#GO:0009987;myoblast fusion#GO:0007520;striated muscle cell differentiation#GO:0051146;syncytium formation by cell-cell fusion#GO:0000768;cellular developmental process#GO:0048869;anatomical structure development#GO:0048856;developmental process#GO:0032502;cell-cell fusion#GO:0140253;animal gross anatomical part developmental process#GO:0160108 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 guanyl-nucleotide exchange factor#PC00113;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HUMAN|HGNC=1291|UniProtKB=Q9Y3R5 Q9Y3R5 DOP1B PTHR14042:SF23 DOPEY-RELATED PROTEIN DOP1B localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;endosomal transport#GO:0016197;intracellular transport#GO:0046907;Golgi vesicle transport#GO:0048193;transport#GO:0006810;vesicle-mediated transport#GO:0016192;cytosolic transport#GO:0016482;retrograde transport, vesicle recycling within Golgi#GO:0000301;retrograde transport, endosome to Golgi#GO:0042147;establishment of localization in cell#GO:0051649;intra-Golgi vesicle-mediated transport#GO:0006891;cellular process#GO:0009987 vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endosome#GO:0005768;endosome membrane#GO:0010008;organelle subcompartment#GO:0031984;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;vesicle membrane#GO:0012506;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;early endosome membrane#GO:0031901;Golgi apparatus#GO:0005794;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588 HUMAN|Ensembl=ENSG00000284912.1|UniProtKB=A0A2R8YE69 A0A2R8YE69 PTHR23158:SF57 MELANOMA INHIBITORY ACTIVITY-RELATED CTAGE FAMILY MEMBER 15-RELATED intracellular protein localization#GO:0008104;establishment of protein localization to extracellular region#GO:0035592;establishment of localization#GO:0051234;Golgi vesicle transport#GO:0048193;transport#GO:0006810;intracellular transport#GO:0046907;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;macromolecule localization#GO:0033036;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;secretion by cell#GO:0032940;protein transport#GO:0015031;localization#GO:0051179;protein secretion#GO:0009306;cellular localization#GO:0051641;secretion#GO:0046903;export from cell#GO:0140352;protein localization to extracellular region#GO:0071692 endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum exit site#GO:0070971;endoplasmic reticulum#GO:0005783;organelle membrane#GO:0031090;membrane#GO:0016020;endomembrane system#GO:0012505;cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 membrane traffic protein#PC00150 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HUMAN|HGNC=1589|UniProtKB=P24864 P24864 CCNE1 PTHR10177:SF71 CYCLINS G1_S-SPECIFIC CYCLIN-E1 enzyme regulator activity#GO:0030234;cyclin-dependent protein kinase regulator activity#GO:0019914;protein kinase regulator activity#GO:0019887;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538 positive regulation of mitotic cell cycle#GO:0045931;mitotic cell cycle process#GO:1903047;G1/S transition of mitotic cell cycle#GO:0000082;positive regulation of cell cycle G1/S phase transition#GO:1902808;positive regulation of cell cycle#GO:0045787;biological regulation#GO:0065007;regulation of cell cycle process#GO:0010564;cellular process#GO:0009987;regulation of mitotic cell cycle#GO:0007346;cell cycle G1/S phase transition#GO:0044843;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of mitotic cell cycle phase transition#GO:1901990;regulation of G1/S transition of mitotic cell cycle#GO:2000045;mitotic cell cycle phase transition#GO:0044772;regulation of cell cycle#GO:0051726;regulation of cell cycle G1/S phase transition#GO:1902806;regulation of cellular process#GO:0050794;cell cycle phase transition#GO:0044770;mitotic cell cycle#GO:0000278;cell cycle process#GO:0022402;positive regulation of cell cycle process#GO:0090068;regulation of biological process#GO:0050789;cell cycle#GO:0007049;regulation of cell cycle phase transition#GO:1901987 membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554;protein kinase complex#GO:1902911;intracellular anatomical structure#GO:0005622;transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex#GO:1990234;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 kinase activator#PC00138 p53 pathway#P00059>Cyclin E#P04610;Cell cycle#P00013>Cyclin E#P00483;Cell cycle#P00013>CdkC#P00489;p53 pathway feedback loops 2#P04398>cyclin E#P04664;Parkinson disease#P00049>Cyclin E#P01213 HUMAN|HGNC=17817|UniProtKB=Q53G44 Q53G44 IFI44L PTHR14241:SF2 INTERFERON-INDUCED PROTEIN 44 INTERFERON-INDUCED PROTEIN 44-LIKE immune response#GO:0006955;immune system process#GO:0002376;response to stimulus#GO:0050896 HUMAN|HGNC=10047|UniProtKB=P34096 P34096 RNASE4 PTHR11437:SF53 RIBONUCLEASE RIBONUCLEASE 4 RNA nuclease activity#GO:0004540;nuclease activity#GO:0004518;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 response to biotic stimulus#GO:0009607;response to stress#GO:0006950;defense response to Gram-positive bacterium#GO:0050830;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to other organism#GO:0051707;response to bacterium#GO:0009617;defense response to bacterium#GO:0042742;response to external stimulus#GO:0009605;defense response#GO:0006952 endoribonuclease#PC00094;RNA metabolism protein#PC00031 HUMAN|HGNC=14297|UniProtKB=Q5W111 Q5W111 SPRYD7 PTHR20951:SF2 C13ORF1 PROTEIN-RELATED SPRY DOMAIN-CONTAINING PROTEIN 7 HUMAN|HGNC=8175|UniProtKB=P30954 P30954 OR10J1 PTHR26451:SF344 G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN OLFACTORY RECEPTOR 10J1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;binding#GO:0005488;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 nervous system process#GO:0050877;sensory perception#GO:0007600;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;system process#GO:0003008;detection of chemical stimulus#GO:0009593;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;response to stimulus#GO:0050896;response to chemical#GO:0042221 cellular anatomical structure#GO:0110165;membrane#GO:0016020 G-protein coupled receptor#PC00021 HUMAN|HGNC=3024|UniProtKB=P35462 P35462 DRD3 PTHR24248:SF154 ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR D(3) DOPAMINE RECEPTOR signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;postsynaptic neurotransmitter receptor activity#GO:0098960;transmembrane signaling receptor activity#GO:0004888;neurotransmitter receptor activity#GO:0030594 adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;negative regulation of cellular process#GO:0048523;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway#GO:0007193;cellular process#GO:0009987;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;G protein-coupled dopamine receptor signaling pathway#GO:0007212;biological regulation#GO:0065007;cellular response to nitrogen compound#GO:1901699;regulation of trans-synaptic signaling#GO:0099177;response to chemical#GO:0042221;regulation of signaling#GO:0023051;response to oxygen-containing compound#GO:1901700;G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648;adrenergic receptor signaling pathway#GO:0071875;response to nitrogen compound#GO:1901698;cell communication#GO:0007154;regulation of synaptic transmission, glutamatergic#GO:0051966;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of cell communication#GO:0010646;modulation of chemical synaptic transmission#GO:0050804;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GoPCR#P00725;Dopamine receptor mediated signaling pathway#P05912>D2/D3/D4#P05965;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;Nicotine pharmacodynamics pathway#P06587>DRD2/ DRD3/ DRD4#P06603 HUMAN|HGNC=10867|UniProtKB=Q9UJ37 Q9UJ37 ST6GALNAC2 PTHR45941:SF5 ALPHA-N-ACETYLGALACTOSAMINIDE ALPHA-2,6-SIALYLTRANSFERASE 2-LIKE-RELATED ALPHA-N-ACETYLGALACTOSAMINIDE ALPHA-2,6-SIALYLTRANSFERASE 2 sialyltransferase activity#GO:0008373;glycosyltransferase activity#GO:0016757;transferase activity#GO:0016740;catalytic activity#GO:0003824 biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;macromolecule biosynthetic process#GO:0009059;protein O-linked glycosylation#GO:0006493;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100 HUMAN|HGNC=26655|UniProtKB=Q8NA82 Q8NA82 MARCHF10 PTHR14471:SF5 MARCH7/10 E3 UBIQUITIN PROTEIN LIGASE FAMILY MEMBER E3 UBIQUITIN-PROTEIN LIGASE MARCHF10-RELATED ubiquitin-protein ligase#PC00234 HUMAN|HGNC=11543|UniProtKB=Q12962 Q12962 TAF10 PTHR21242:SF0 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10 protein complex scaffold activity#GO:0140378;structural molecule activity#GO:0005198 DNA-templated transcription initiation#GO:0006352;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;transcription initiation at RNA polymerase II promoter#GO:0006367;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;transcription by RNA polymerase II#GO:0006366 protein-containing complex#GO:0032991;transcription factor TFIID complex#GO:0005669;intracellular membraneless organelle#GO:0043232;SAGA complex#GO:0000124;chromatin#GO:0000785;nuclear protein-containing complex#GO:0140513;histone acetyltransferase complex#GO:0000123;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;organelle lumen#GO:0043233;acetyltransferase complex#GO:1902493;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;protein acetyltransferase complex#GO:0031248;intracellular organelle#GO:0043229;peptidase complex#GO:1905368;RNA polymerase II transcription regulator complex#GO:0090575;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;membraneless organelle#GO:0043228;intracellular protein-containing complex#GO:0140535;transcription regulator complex#GO:0005667;transferase complex#GO:1990234;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;nuclear DNA-directed RNA polymerase complex#GO:0055029;RNA polymerase II, holoenzyme#GO:0016591;SAGA-type complex#GO:0070461;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;catalytic complex#GO:1902494 general transcription factor#PC00259;RNA metabolism protein#PC00031 HUMAN|HGNC=5047|UniProtKB=O43390 O43390 HNRNPR PTHR21245:SF5 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN R RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729 intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 RNA metabolism protein#PC00031 HUMAN|HGNC=25021|UniProtKB=Q2TB18 Q2TB18 ASTE1 PTHR15665:SF1 ASTEROID PROTEIN SINGLE-STRAND DNA ENDONUCLEASE ASTE1 HUMAN|HGNC=11976|UniProtKB=P22105 P22105 TNXB PTHR46708:SF3 TENASCIN TENASCIN-X extracellular matrix protein#PC00102 HUMAN|HGNC=89|UniProtKB=P11310 P11310 ACADM PTHR48083:SF41 MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;oxidoreductase activity#GO:0016491 fatty acid catabolic process#GO:0009062;lipid oxidation#GO:0034440;oxoacid metabolic process#GO:0043436;small molecule catabolic process#GO:0044282;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;monocarboxylic acid metabolic process#GO:0032787;lipid modification#GO:0030258;fatty acid beta-oxidation#GO:0006635;lipid metabolic process#GO:0006629;fatty acid oxidation#GO:0019395;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;monocarboxylic acid catabolic process#GO:0072329;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;lipid catabolic process#GO:0016042 mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 dehydrogenase#PC00092 HUMAN|HGNC=26565|UniProtKB=Q8WW33 Q8WW33 GTSF1 PTHR21402:SF9 GAMETOCYTE SPECIFIC FACTOR 1-RELATED GAMETOCYTE-SPECIFIC FACTOR 1 HUMAN|HGNC=18838|UniProtKB=Q8WUF5 Q8WUF5 PPP1R13L PTHR24164:SF5 RELA-ASSOCIATED INHIBITOR RELA-ASSOCIATED INHIBITOR regulation of developmental process#GO:0050793;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of developmental process#GO:0051094;regulation of cell differentiation#GO:0045595;positive regulation of cell differentiation#GO:0045597 HUMAN|HGNC=13018|UniProtKB=Q9UK10 Q9UK10 ZNF225 PTHR24376:SF129 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 224-RELATED zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=16913|UniProtKB=Q9NSA3 Q9NSA3 CTNNBIP1 PTHR47142:SF1 BETA-CATENIN-INTERACTING PROTEIN 1 BETA-CATENIN-INTERACTING PROTEIN 1 protein binding#GO:0005515;beta-catenin binding#GO:0008013;binding#GO:0005488 negative regulation of cell communication#GO:0010648;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;negative regulation of cellular process#GO:0048523;negative regulation of signaling#GO:0023057;negative regulation of signal transduction#GO:0009968;regulation of Wnt signaling pathway#GO:0030111;regulation of cell communication#GO:0010646;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of response to stimulus#GO:0048585;negative regulation of Wnt signaling pathway#GO:0030178;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519 intracellular organelle#GO:0043229;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 HUMAN|HGNC=7645|UniProtKB=P18440 P18440 NAT1 PTHR11786:SF8 N-HYDROXYARYLAMINE O-ACETYLTRANSFERASE ARYLAMINE N-ACETYLTRANSFERASE 1 acetyltransferase activity#GO:0016407;catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;N-acetyltransferase activity#GO:0008080;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 acetyltransferase#PC00038 HUMAN|HGNC=28514|UniProtKB=Q8N8E3 Q8N8E3 CEP112 PTHR18871:SF2 CENTROSOMAL PROTEIN OF 112 KDA CENTROSOMAL PROTEIN OF 112 KDA HUMAN|HGNC=16239|UniProtKB=Q9H4K7 Q9H4K7 MTG2 PTHR11702:SF31 DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN-RELATED MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 2 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;nucleoside phosphate binding#GO:1901265;guanyl nucleotide binding#GO:0019001;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;hydrolase activity, acting on acid anhydrides#GO:0016817;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;small molecule binding#GO:0036094;anion binding#GO:0043168;ion binding#GO:0043167;GTPase activity#GO:0003924;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleotide binding#GO:0000166 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=937|UniProtKB=Q99933 Q99933 BAG1 PTHR12329:SF52 BCL2-ASSOCIATED ATHANOGENE BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1 molecular function regulator activity#GO:0098772;nucleoside-triphosphatase regulator activity#GO:0060589;protein binding#GO:0005515;enzyme regulator activity#GO:0030234;protein-folding chaperone binding#GO:0051087;binding#GO:0005488 biological regulation#GO:0065007;regulation of biological quality#GO:0065008;protein stabilization#GO:0050821;regulation of protein stability#GO:0031647 membrane#GO:0016020;cytosol#GO:0005829;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 chaperone#PC00072 Apoptosis signaling pathway#P00006>Bag#P00278 HUMAN|HGNC=25208|UniProtKB=Q8WTR8 Q8WTR8 NTN5 PTHR10574:SF262 NETRIN/LAMININ-RELATED NETRIN-5 system development#GO:0048731;anatomical structure development#GO:0048856;neurogenesis#GO:0022008;neuron projection guidance#GO:0097485;cellular developmental process#GO:0048869;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;plasma membrane bounded cell projection organization#GO:0120036;multicellular organismal process#GO:0032501;tissue development#GO:0009888;axon guidance#GO:0007411;axon development#GO:0061564;neuron development#GO:0048666;axonogenesis#GO:0007409;dendrite development#GO:0016358;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;cell morphogenesis#GO:0000902;cell differentiation#GO:0030154;cell projection organization#GO:0030030;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;motor neuron axon guidance#GO:0008045;cell projection morphogenesis#GO:0048858;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;cellular process#GO:0009987;neuron projection development#GO:0031175 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;basement membrane#GO:0005604;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 extracellular matrix protein#PC00102 HUMAN|HGNC=29897|UniProtKB=Q8WV22 Q8WV22 NSMCE1 PTHR20973:SF0 NON-SMC ELEMENT 1-RELATED NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 1 HOMOLOG ubiquitin-protein transferase activity#GO:0004842;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746 nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;response to stress#GO:0006950;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;DNA recombination#GO:0006310;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA metabolic process#GO:0006259;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;double-strand break repair via homologous recombination#GO:0000724;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular response to stress#GO:0033554;recombinational repair#GO:0000725 transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;condensed chromosome#GO:0000793;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;nucleus#GO:0005634;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 HUMAN|HGNC=8787|UniProtKB=P51160 P51160 PDE6C PTHR11347:SF23 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE CONE CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT ALPHA' catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphoric ester hydrolase activity#GO:0042578;phosphoric diester hydrolase activity#GO:0008081;hydrolase activity#GO:0016787;cyclic-nucleotide phosphodiesterase activity#GO:0004112 negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;negative regulation of response to stimulus#GO:0048585;system process#GO:0003008;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;visual perception#GO:0007601;regulation of biological process#GO:0050789;sensory perception of light stimulus#GO:0050953;negative regulation of biological process#GO:0048519;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;nervous system process#GO:0050877;regulation of signaling#GO:0023051;sensory perception#GO:0007600;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057 hydrolase#PC00121;phosphodiesterase#PC00185 HUMAN|HGNC=21224|UniProtKB=Q96AP4 Q96AP4 ZUP1 PTHR24403:SF82 ZINC FINGER PROTEIN ZINC FINGER-CONTAINING UBIQUITIN PEPTIDASE 1 double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=4421|UniProtKB=P30968 P30968 GNRHR PTHR24241:SF22 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR GONADOTROPIN-RELEASING HORMONE RECEPTOR signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 cellular process#GO:0009987;signal transduction#GO:0007165;response to hormone#GO:0009725;biological regulation#GO:0065007;response to chemical#GO:0042221;G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;signaling#GO:0023052;regulation of cellular process#GO:0050794;cellular response to hormone stimulus#GO:0032870;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 Gonadotropin-releasing hormone receptor pathway#P06664>GnRHR#P06727;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GsPCR#P00720;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GqPCR#P00730;Gonadotropin-releasing hormone receptor pathway#P06664>GnRHR#G06676;Gonadotropin-releasing hormone receptor pathway#P06664>GnRHR#G06892 HUMAN|HGNC=11909|UniProtKB=O00300 O00300 TNFRSF11B PTHR23097:SF90 TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 11B transmembrane signal receptor#PC00197 HUMAN|HGNC=23449|UniProtKB=Q5VZR2 Q5VZR2 NUTM2G PTHR22879:SF2 NUT FAMILY MEMBER 1 NUT FAMILY MEMBER 2F-RELATED HUMAN|HGNC=16798|UniProtKB=Q5VY80 Q5VY80 RAET1L PTHR16675:SF148 MHC CLASS I-RELATED UL16-BINDING PROTEIN 2-RELATED molecular function activator activity#GO:0140677;protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545 natural killer cell mediated immunity#GO:0002228;regulation of biological process#GO:0050789;leukocyte mediated cytotoxicity#GO:0001909;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;positive regulation of adaptive immune response#GO:0002821;regulation of cell killing#GO:0031341;immune system process#GO:0002376;regulation of lymphocyte mediated immunity#GO:0002706;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;defense response to symbiont#GO:0140546;positive regulation of immune system process#GO:0002684;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;defense response to other organism#GO:0098542;immune effector process#GO:0002252;natural killer cell mediated cytotoxicity#GO:0042267;regulation of leukocyte mediated immunity#GO:0002703;response to external biotic stimulus#GO:0043207;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of immune response#GO:0050776;regulation of leukocyte mediated cytotoxicity#GO:0001910;regulation of immune effector process#GO:0002697;antigen processing and presentation#GO:0019882;positive regulation of lymphocyte mediated immunity#GO:0002708;immune response#GO:0006955;positive regulation of cellular process#GO:0048522;response to other organism#GO:0051707;positive regulation of immune effector process#GO:0002699;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;cell killing#GO:0001906;positive regulation of leukocyte mediated immunity#GO:0002705;defense response#GO:0006952;response to external stimulus#GO:0009605;innate immune response#GO:0045087 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;plasma membrane#GO:0005886;external side of plasma membrane#GO:0009897;extracellular region#GO:0005576;side of membrane#GO:0098552 major histocompatibility complex protein#PC00149;defense/immunity protein#PC00090 HUMAN|HGNC=33202|UniProtKB=P0CH99 P0CH99 ZNF705D PTHR24381:SF303 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 705A-RELATED double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=30248|UniProtKB=Q9BZL3 Q9BZL3 SMIM3 PTHR37859:SF1 SMALL INTEGRAL MEMBRANE PROTEIN 3 SMALL INTEGRAL MEMBRANE PROTEIN 3 HUMAN|HGNC=23023|UniProtKB=Q9UPU9 Q9UPU9 SAMD4A PTHR12515:SF8 STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 4-RELATED PROTEIN SMAUG HOMOLOG 1 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729 nucleobase-containing compound catabolic process#GO:0034655;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;nucleic acid catabolic process#GO:0141188;regulation of nucleobase-containing compound metabolic process#GO:0019219;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;macromolecule metabolic process#GO:0043170;positive regulation of catabolic process#GO:0009896;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;positive regulation of mRNA catabolic process#GO:0061014;regulation of macromolecule metabolic process#GO:0060255;nuclear-transcribed mRNA poly(A) tail shortening#GO:0000289;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;regulation of RNA stability#GO:0043487;regulation of RNA metabolic process#GO:0051252;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;RNA destabilization#GO:0050779;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;metabolic process#GO:0008152;positive regulation of mRNA metabolic process#GO:1903313;macromolecule catabolic process#GO:0009057;mRNA destabilization#GO:0061157;regulation of mRNA metabolic process#GO:1903311;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;regulation of mRNA stability#GO:0043488;RNA catabolic process#GO:0006401;positive regulation of metabolic process#GO:0009893;RNA metabolic process#GO:0016070;regulation of biological quality#GO:0065008 cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;organelle#GO:0043226;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;P-body#GO:0000932 HUMAN|HGNC=29409|UniProtKB=Q8TF61 Q8TF61 FBXO41 PTHR15739:SF4 ZINC FINGER PROTEIN F-BOX ONLY PROTEIN 41 HUMAN|HGNC=20669|UniProtKB=Q86VI3 Q86VI3 IQGAP3 PTHR14149:SF10 RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF RAS GTPASE-ACTIVATING-LIKE PROTEIN IQGAP3 binding#GO:0005488;actin filament binding#GO:0051015;actin binding#GO:0003779;protein binding#GO:0005515;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;protein-containing complex binding#GO:0044877;enzyme activator activity#GO:0008047;calmodulin binding#GO:0005516;cytoskeletal protein binding#GO:0008092;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function regulator activity#GO:0098772 actomyosin structure organization#GO:0031032;mitotic cell cycle#GO:0000278;mitotic cytokinesis#GO:0000281;actin cytoskeleton organization#GO:0030036;cell division#GO:0051301;cell cycle process#GO:0022402;cell cycle#GO:0007049;cellular component organization#GO:0016043;supramolecular fiber organization#GO:0097435;cytoskeleton-dependent cytokinesis#GO:0061640;cortical actin cytoskeleton organization#GO:0030866;mitotic cytokinetic process#GO:1902410;actin filament-based process#GO:0030029;cytokinetic process#GO:0032506;cortical cytoskeleton organization#GO:0030865;cytokinesis#GO:0000910;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;actomyosin contractile ring assembly#GO:0000915;mitotic cell cycle process#GO:1903047;actin filament organization#GO:0007015;cellular component organization or biogenesis#GO:0071840 cell periphery#GO:0071944;cell cortex#GO:0005938;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 GTPase-activating protein#PC00257 HUMAN|HGNC=21722|UniProtKB=Q8N865 Q8N865 SPMIP4 PTHR31393:SF2 C5ORF31 SPERM-ASSOCIATED MICROTUBULE INNER PROTEIN 4 microtubule organizing center#GO:0005815;centrosome#GO:0005813;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;microtubule cytoskeleton#GO:0015630;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232 HUMAN|HGNC=3622|UniProtKB=O75072 O75072 FKTN PTHR15407:SF42 FUKUTIN-RELATED RIBITOL-5-PHOSPHATE TRANSFERASE FKTN cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;biosynthetic process#GO:0009058;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;intracellular organelle#GO:0043229 HUMAN|HGNC=16887|UniProtKB=Q13113 Q13113 PDZK1IP1 PTHR15296:SF0 MEMBRANE-ASSOCIATED PROTEIN MAP17 PDZK1-INTERACTING PROTEIN 1 HUMAN|HGNC=7802|UniProtKB=Q6P4R8 Q6P4R8 NFRKB PTHR13052:SF3 NFRKB-RELATED NUCLEAR FACTOR RELATED TO KAPPA-B-BINDING PROTEIN binding#GO:0005488;enzyme binding#GO:0019899;protease binding#GO:0002020;protein binding#GO:0005515 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=1954|UniProtKB=P08912 P08912 CHRM5 PTHR24247:SF209 5-HYDROXYTRYPTAMINE RECEPTOR MUSCARINIC ACETYLCHOLINE RECEPTOR M5 G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;neurotransmitter receptor activity#GO:0030594;G protein-coupled amine receptor activity#GO:0008227;molecular transducer activity#GO:0060089;acetylcholine receptor activity#GO:0015464;transmembrane signaling receptor activity#GO:0004888;postsynaptic neurotransmitter receptor activity#GO:0098960 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway#GO:0007193;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;response to chemical#GO:0042221;acetylcholine receptor signaling pathway#GO:0095500;cellular response to nitrogen compound#GO:1901699;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;synaptic signaling#GO:0099536;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;cellular process#GO:0009987;cell communication#GO:0007154;response to nitrogen compound#GO:1901698;G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887;trans-synaptic signaling#GO:0099537;response to oxygen-containing compound#GO:1901700;anterograde trans-synaptic signaling#GO:0098916;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716 cellular anatomical structure#GO:0110165;synapse#GO:0045202;cell projection#GO:0042995;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;plasma membrane bounded cell projection#GO:0120025;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;cell junction#GO:0030054;dendrite#GO:0030425;dendritic tree#GO:0097447 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GqPCR#P00730;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;Alzheimer disease-amyloid secretase pathway#P00003>Muscarinic acetylcholine receptors#P00083;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GoPCR#P00725 HUMAN|HGNC=17197|UniProtKB=Q96LW1 Q96LW1 ZNF354B PTHR24377:SF641 IP01015P-RELATED ZINC FINGER PROTEIN 354B sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=34549|UniProtKB=A6NKC9 A6NKC9 SH2D7 PTHR14388:SF6 T CELL-SPECIFIC ADAPTER PROTEIN TSAD SH2 DOMAIN-CONTAINING PROTEIN 7 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090 HUMAN|HGNC=6345|UniProtKB=Q13351 Q13351 KLF1 PTHR23235:SF133 KRUEPPEL-LIKE TRANSCRIPTION FACTOR KRUEPPEL-LIKE FACTOR 1 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=14767|UniProtKB=Q8NGV6 Q8NGV6 OR5H6 PTHR26452:SF754 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5H6 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 sensory perception of chemical stimulus#GO:0007606;sensory perception#GO:0007600;nervous system process#GO:0050877;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;system process#GO:0003008 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=21225|UniProtKB=Q75N03 Q75N03 CBLL1 PTHR13480:SF2 E3 UBIQUITIN-PROTEIN LIGASE HAKAI-RELATED E3 UBIQUITIN-PROTEIN LIGASE HAKAI transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659 regulation of cell adhesion#GO:0030155;regulation of cellular process#GO:0050794;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;biological regulation#GO:0065007;primary metabolic process#GO:0044238;protein modification process#GO:0036211;cellular process#GO:0009987;protein modification by small protein conjugation#GO:0032446;regulation of biological process#GO:0050789;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=88|UniProtKB=P28330 P28330 ACADL PTHR48083:SF20 MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED LONG-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL nucleotide binding#GO:0000166;heterocyclic compound binding#GO:1901363;oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;small molecule binding#GO:0036094;flavin adenine dinucleotide binding#GO:0050660;anion binding#GO:0043168 lipid oxidation#GO:0034440;fatty acid catabolic process#GO:0009062;oxoacid metabolic process#GO:0043436;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;small molecule catabolic process#GO:0044282;carboxylic acid metabolic process#GO:0019752;modified amino acid metabolic process#GO:0006575;primary metabolic process#GO:0044238;monocarboxylic acid metabolic process#GO:0032787;carnitine metabolic process#GO:0009437;lipid modification#GO:0030258;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;fatty acid beta-oxidation#GO:0006635;lipid metabolic process#GO:0006629;fatty acid oxidation#GO:0019395;monocarboxylic acid catabolic process#GO:0072329;long-chain fatty acid metabolic process#GO:0001676;cellular process#GO:0009987;lipid catabolic process#GO:0016042;carboxylic acid catabolic process#GO:0046395 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739 dehydrogenase#PC00092 HUMAN|HGNC=33732|UniProtKB=Q7Z4L9 Q7Z4L9 PPP1R42 PTHR45973:SF30 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 42 phosphatase modulator#PC00184;protein-binding activity modulator#PC00095 HUMAN|HGNC=249|UniProtKB=P07327 P07327 ADH1A PTHR43880:SF73 ALCOHOL DEHYDROGENASE ALCOHOL DEHYDROGENASE 1A oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;metal ion binding#GO:0046872;cation binding#GO:0043169;all-trans-retinol dehydrogenase (NAD+) activity#GO:0004745;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;transition metal ion binding#GO:0046914;oxidoreductase activity#GO:0016491;alcohol dehydrogenase (NAD+) activity#GO:0004022;zinc ion binding#GO:0008270;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;catalytic activity#GO:0003824 hormone metabolic process#GO:0042445;biological regulation#GO:0065007;aldehyde catabolic process#GO:0046185;retinoid metabolic process#GO:0001523;diterpenoid metabolic process#GO:0016101;lipid metabolic process#GO:0006629;catabolic process#GO:0009056;response to toxic substance#GO:0009636;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;isoprenoid metabolic process#GO:0006720;retinol metabolic process#GO:0042572;terpenoid metabolic process#GO:0006721;response to chemical#GO:0042221;detoxification#GO:0098754;cellular response to toxic substance#GO:0097237;cellular response to oxygen-containing compound#GO:1901701;aldehyde metabolic process#GO:0006081;cellular process#GO:0009987;metabolic process#GO:0008152;alcohol metabolic process#GO:0006066;small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;small molecule catabolic process#GO:0044282;monocarboxylic acid metabolic process#GO:0032787;cellular detoxification of aldehyde#GO:0110095;carboxylic acid metabolic process#GO:0019752;regulation of hormone levels#GO:0010817;regulation of biological quality#GO:0065008;cellular response to chemical stimulus#GO:0070887;oxoacid metabolic process#GO:0043436;olefinic compound metabolic process#GO:0120254;response to oxygen-containing compound#GO:1901700;cellular detoxification#GO:1990748 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 dehydrogenase#PC00092 HUMAN|HGNC=773|UniProtKB=O14525 O14525 ASTN1 PTHR16592:SF8 ASTROTACTIN-1-LIKE ASTROTACTIN-1 cell adhesion#GO:0007155;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;anatomical structure development#GO:0048856;cell differentiation#GO:0030154;cell motility#GO:0048870;developmental process#GO:0032502;neurogenesis#GO:0022008;multicellular organism development#GO:0007275;neuron migration#GO:0001764;cellular developmental process#GO:0048869;cellular process#GO:0009987;cell-cell adhesion#GO:0098609;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;cell migration#GO:0016477 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;intracellular vesicle#GO:0097708;vesicle#GO:0031982;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;intracellular organelle#GO:0043229 HUMAN|HGNC=30064|UniProtKB=Q86U86 Q86U86 PBRM1 PTHR16062:SF19 SWI/SNF-RELATED PROTEIN POLYBROMO-1 chromatin binding#GO:0003682;binding#GO:0005488 cellular process#GO:0009987;cellular component organization#GO:0016043;chromatin organization#GO:0006325;chromatin remodeling#GO:0006338;cellular component organization or biogenesis#GO:0071840 membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;chromatin#GO:0000785;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;ATPase complex#GO:1904949;intracellular organelle#GO:0043229;SWI/SNF complex#GO:0016514;catalytic complex#GO:1902494;RSC-type complex#GO:0016586;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;SWI/SNF superfamily-type complex#GO:0070603;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=11136|UniProtKB=Q92966 Q92966 SNAPC3 PTHR13421:SF16 SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 3 SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 3 nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;core promoter sequence-specific DNA binding#GO:0001046;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;transcription by RNA polymerase II#GO:0006366;snRNA transcription#GO:0009301;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;snRNA transcription by RNA polymerase II#GO:0042795;transcription by RNA polymerase III#GO:0006383;snRNA transcription by RNA polymerase III#GO:0042796;snRNA metabolic process#GO:0016073;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187 protein-containing complex#GO:0032991;transcription regulator complex#GO:0005667 general transcription factor#PC00259;RNA metabolism protein#PC00031 HUMAN|HGNC=264|UniProtKB=P29275 P29275 ADORA2B PTHR24246:SF18 OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR ADENOSINE RECEPTOR A2B molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 system process#GO:0003008;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;regulation of anatomical structure size#GO:0090066;biological regulation#GO:0065007;blood circulation#GO:0008015;multicellular organismal process#GO:0032501;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of biological quality#GO:0065008;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;circulatory system process#GO:0003013;signaling#GO:0023052;vasodilation#GO:0042311;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GoPCR#P00725;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711 HUMAN|HGNC=3679|UniProtKB=Q9HCT0 Q9HCT0 FGF22 PTHR11486:SF41 FIBROBLAST GROWTH FACTOR FIBROBLAST GROWTH FACTOR 22 signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515;molecular function activator activity#GO:0140677;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;growth factor activity#GO:0008083;growth factor receptor binding#GO:0070851;fibroblast growth factor receptor binding#GO:0005104;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546 multicellular organism development#GO:0007275;cell surface receptor signaling pathway#GO:0007166;regulation of MAPK cascade#GO:0043408;nervous system development#GO:0007399;cellular process#GO:0009987;cellular response to fibroblast growth factor stimulus#GO:0044344;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular response to growth factor stimulus#GO:0071363;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;animal gross anatomical part developmental process#GO:0160108;regulation of intracellular signal transduction#GO:1902531;signaling#GO:0023052;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;cell differentiation#GO:0030154;regulation of biological process#GO:0050789;positive regulation of cell population proliferation#GO:0008284;response to endogenous stimulus#GO:0009719;neurogenesis#GO:0022008;positive regulation of MAPK cascade#GO:0043410;cellular developmental process#GO:0048869;regulation of response to stimulus#GO:0048583;developmental process#GO:0032502;positive regulation of intracellular signal transduction#GO:1902533;regulation of cell migration#GO:0030334;response to fibroblast growth factor#GO:0071774;regulation of locomotion#GO:0040012;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;multicellular organismal process#GO:0032501;fibroblast growth factor receptor signaling pathway#GO:0008543;positive regulation of response to stimulus#GO:0048584;positive regulation of cellular process#GO:0048522;system development#GO:0048731;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of cell population proliferation#GO:0042127;regulation of cell motility#GO:2000145;cell communication#GO:0007154;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of cell communication#GO:0010646;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;response to growth factor#GO:0070848;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967 extracellular region#GO:0005576;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207;growth factor#PC00112 FGF signaling pathway#P00021>FGF#P00623 HUMAN|HGNC=29442|UniProtKB=O75037 O75037 KIF21B PTHR24115:SF893 KINESIN-RELATED KINESIN-LIKE PROTEIN KIF21B hydrolase activity, acting on acid anhydrides#GO:0016817;cytoskeletal protein binding#GO:0008092;cytoskeletal motor activity#GO:0003774;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;ATP-dependent activity#GO:0140657;protein binding#GO:0005515;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;macromolecular conformation isomerase activity#GO:0120543;tubulin binding#GO:0015631;ribonucleoside triphosphate phosphatase activity#GO:0017111;isomerase activity#GO:0016853;polypeptide conformation or assembly isomerase activity#GO:0120544;microtubule binding#GO:0008017;hydrolase activity#GO:0016787;microtubule motor activity#GO:0003777;ATP hydrolysis activity#GO:0016887 cellular process#GO:0009987;microtubule-based process#GO:0007017;microtubule-based movement#GO:0007018 organelle#GO:0043226;cellular anatomical structure#GO:0110165;microtubule#GO:0005874;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;microtubule associated complex#GO:0005875;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cytoskeleton#GO:0005856 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=31865|UniProtKB=Q9H903 Q9H903 MTHFD2L PTHR48099:SF7 C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE_CYCLOHYDROLASE 2, MITOCHONDRIAL catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;oxidoreductase activity#GO:0016491;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814 metabolic process#GO:0008152;tetrahydrofolate biosynthetic process#GO:0046654;tetrahydrofolate metabolic process#GO:0046653;modified amino acid metabolic process#GO:0006575;cellular process#GO:0009987;folic acid-containing compound metabolic process#GO:0006760;pteridine-containing compound metabolic process#GO:0042558;small molecule metabolic process#GO:0044281;biosynthetic process#GO:0009058 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cytosol#GO:0005829;mitochondrion#GO:0005739 metabolite interconversion enzyme#PC00262 Formyltetrahydrofolate biosynthesis#P02743>Methylene tetrahydrofolate dehydrogenase#P02952 HUMAN|HGNC=25616|UniProtKB=Q96B02 Q96B02 UBE2W PTHR24068:SF153 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2 W transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin conjugating enzyme activity#GO:0061631;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-like protein conjugating enzyme activity#GO:0061650;ubiquitin-protein transferase activity#GO:0004842 protein ubiquitination#GO:0016567;proteasomal protein catabolic process#GO:0010498;post-translational protein modification#GO:0043687;cellular process#GO:0009987;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;catabolic process#GO:0009056;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;protein modification process#GO:0036211;primary metabolic process#GO:0044238;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein modification by small protein conjugation or removal#GO:0070647 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=28943|UniProtKB=Q53RY4 Q53RY4 KRTCAP3 PTHR31258:SF1 KERATINOCYTE-ASSOCIATED PROTEIN 3 KERATINOCYTE-ASSOCIATED PROTEIN 3 HUMAN|HGNC=4038|UniProtKB=Q9UP38 Q9UP38 FZD1 PTHR11309:SF81 FRIZZLED FRIZZLED-1 signaling receptor activity#GO:0038023;Wnt-protein binding#GO:0017147;protein binding#GO:0005515;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488 cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;canonical Wnt signaling pathway#GO:0060070;non-canonical Wnt signaling pathway#GO:0035567;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;Wnt signaling pathway#GO:0016055;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 Angiogenesis#P00005>Fzd#P00189;Cadherin signaling pathway#P00012>Frizzled#P00475;Wnt signaling pathway#P00057>Frizzled#P01428;Angiogenesis#P00005>FRP#P00237;Alzheimer disease-presenilin pathway#P00004>Frizzled#P00119 HUMAN|HGNC=5302|UniProtKB=P34969 P34969 HTR7 PTHR24247:SF116 5-HYDROXYTRYPTAMINE RECEPTOR 5-HYDROXYTRYPTAMINE RECEPTOR 7 neurotransmitter receptor activity#GO:0030594;G protein-coupled amine receptor activity#GO:0008227;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023 trans-synaptic signaling#GO:0099537;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;chemical synaptic transmission#GO:0007268;synaptic signaling#GO:0099536;signaling#GO:0023052;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;response to stimulus#GO:0050896 dendritic tree#GO:0097447;dendrite#GO:0030425;cell projection#GO:0042995;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165;neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GsPCR#P00720;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711 HUMAN|HGNC=23315|UniProtKB=Q5VYV0 Q5VYV0 FOXB2 PTHR11829:SF215 FORKHEAD BOX PROTEIN FORKHEAD BOX PROTEIN B2 cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;developmental process#GO:0032502;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;cellular process#GO:0009987 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 helix-turn-helix transcription factor#PC00116;gene-specific transcriptional regulator#PC00264;winged helix/forkhead transcription factor#PC00246 HUMAN|HGNC=23750|UniProtKB=Q6NW29 Q6NW29 RWDD4 PTHR21275:SF1 RWD DOMAIN-CONTAINING PROTEIN 4 RWD DOMAIN-CONTAINING PROTEIN 4 HUMAN|HGNC=7450|UniProtKB=Q13614 Q13614 MTMR2 PTHR10807:SF42 MYOTUBULARIN-RELATED PHOSPHATIDYLINOSITOL-3,5-BISPHOSPHATE 3-PHOSPHATASE MTMR2 phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;phosphatidylinositol-3,5-bisphosphate phosphatase activity#GO:0106018;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791 lipid metabolic process#GO:0006629;phosphatidylinositol metabolic process#GO:0046488;metabolic process#GO:0008152;phosphatidylinositol dephosphorylation#GO:0046856;lipid modification#GO:0030258;dephosphorylation#GO:0016311;phospholipid dephosphorylation#GO:0046839;phosphate-containing compound metabolic process#GO:0006796;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phospholipid metabolic process#GO:0006644;glycerolipid metabolic process#GO:0046486;glycerophospholipid metabolic process#GO:0006650 membrane#GO:0016020;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 phosphatase#PC00181 HUMAN|HGNC=13918|UniProtKB=P48634 P48634 PRRC2A PTHR14038:SF5 BAT2 HLA-B-ASSOCIATED TRANSCRIPT 2 PROTEIN PRRC2A nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HUMAN|HGNC=21387|UniProtKB=Q8N3Z0 Q8N3Z0 PRSS35 PTHR15462:SF17 SERINE PROTEASE INACTIVE SERINE PROTEASE 35 serine protease#PC00203 HUMAN|HGNC=21247|UniProtKB=Q7Z4R8 Q7Z4R8 C6orf120 PTHR31703:SF2 UPF0669 PROTEIN C6ORF120 UPF0669 PROTEIN C6ORF120 HUMAN|HGNC=14941|UniProtKB=Q96I34 Q96I34 PPP1R16A PTHR24179:SF30 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 16A enzyme inhibitor activity#GO:0004857;protein phosphatase regulator activity#GO:0019888;molecular function inhibitor activity#GO:0140678;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;phosphatase regulator activity#GO:0019208 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protein-binding activity modulator#PC00095;phosphatase modulator#PC00184 HUMAN|HGNC=13631|UniProtKB=C0HME6 C0HME6 RPL36 PTHR10114:SF28 60S RIBOSOMAL PROTEIN L36 RPL36 ALTERNATIVE READING FRAME PROTEIN structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 cytoplasmic translation#GO:0002181;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;translation#GO:0006412 intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;ribosome#GO:0005840;cytosol#GO:0005829;cytosolic large ribosomal subunit#GO:0022625;cytosolic ribosome#GO:0022626;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934 translational protein#PC00263;ribosomal protein#PC00202 HUMAN|HGNC=4577|UniProtKB=A4D1Z8 A4D1Z8 GRIFIN PTHR11346:SF21 GALECTIN GRIFIN carbohydrate binding#GO:0030246;binding#GO:0005488 extracellular matrix protein#PC00102 HUMAN|HGNC=18556|UniProtKB=Q8NFI4 Q8NFI4 ST13P5 PTHR45883:SF6 HSC70-INTERACTING PROTEIN HSC70-INTERACTING PROTEIN-RELATED Hsp70 protein binding#GO:0030544;protein binding#GO:0005515;heat shock protein binding#GO:0031072;protein-folding chaperone binding#GO:0051087;binding#GO:0005488 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;biosynthetic process#GO:0009058;protein folding#GO:0006457;gene expression#GO:0010467;protein maturation#GO:0051604;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238 HUMAN|HGNC=22135|UniProtKB=Q8IZ16 Q8IZ16 SPACDR PTHR39221:SF1 CHROMOSOME 7 OPEN READING FRAME 61 SPERM ACROSOME DEVELOPMENTAL REGULATOR HUMAN|HGNC=29989|UniProtKB=Q86YP4 Q86YP4 GATAD2A PTHR13455:SF3 TRANSCRIPTIONAL REPRESSOR P66-RELATED TRANSCRIPTIONAL REPRESSOR P66-ALPHA DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110 negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;regulation of gene expression#GO:0010468;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;organelle lumen#GO:0043233;SWI/SNF superfamily-type complex#GO:0070603;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ATPase complex#GO:1904949;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;histone deacetylase complex#GO:0000118;membrane-enclosed lumen#GO:0031974;chromatin#GO:0000785;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;transcription regulator complex#GO:0005667 DNA-binding transcription factor#PC00218 HUMAN|HGNC=14951|UniProtKB=Q5SWA1 Q5SWA1 PPP1R15B PTHR16489:SF11 GH11727P PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 15B molecular function regulator activity#GO:0098772;protein phosphatase regulator activity#GO:0019888;enzyme regulator activity#GO:0030234;phosphatase regulator activity#GO:0019208 response to stimulus#GO:0050896;response to endoplasmic reticulum stress#GO:0034976;response to stress#GO:0006950;cellular response to stress#GO:0033554;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;protein serine/threonine phosphatase complex#GO:0008287;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=11364|UniProtKB=P40763 P40763 STAT3 PTHR11801:SF2 SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 cellular response to chemical stimulus#GO:0070887;response to oxygen-containing compound#GO:1901700;response to peptide#GO:1901652;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;cellular response to hormone stimulus#GO:0032870;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;signaling#GO:0023052;cell surface receptor signaling pathway#GO:0007166;response to stress#GO:0006950;response to hormone#GO:0009725;cellular process#GO:0009987;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;response to cytokine#GO:0034097;response to chemical#GO:0042221;cell surface receptor signaling pathway via STAT#GO:0097696;interleukin-9-mediated signaling pathway#GO:0038113;cytokine-mediated signaling pathway#GO:0019221;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of DNA-templated transcription#GO:0006355;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of cell population proliferation#GO:0042127;cell communication#GO:0007154;regulation of RNA metabolic process#GO:0051252;response to nitrogen compound#GO:1901698;cellular response to stimulus#GO:0051716;interleukin-2-mediated signaling pathway#GO:0038110;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;cellular response to peptide hormone stimulus#GO:0071375;cell surface receptor signaling pathway via JAK-STAT#GO:0007259;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;defense response#GO:0006952;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular response to nitrogen compound#GO:1901699;regulation of nucleobase-containing compound metabolic process#GO:0019219;response to peptide hormone#GO:0043434;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667 immunoglobulin fold transcription factor#PC00251;Rel homology transcription factor#PC00252 Interleukin signaling pathway#P00036>STAT#P00996;CCKR signaling map#P06959>STAT3#P07165;Ras Pathway#P04393>Stat 1/3#P04566;Gonadotropin-releasing hormone receptor pathway#P06664>STAT3#P06795;PDGF signaling pathway#P00047>STAT#P01173;EGF receptor signaling pathway#P00018>STAT#P00561;Angiogenesis#P00005>STAT3#P00217;JAK/STAT signaling pathway#P00038>STAT#P01027;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>STAT#P00832 HUMAN|HGNC=53217|UniProtKB=A0A1B0GVD1 A0A1B0GVD1 FAM237B PTHR36690:SF1 PROTEIN FAM237A PROTEIN FAM237B HUMAN|HGNC=1334|UniProtKB=Q96IV6 Q96IV6 FAXDC2 PTHR11863:SF241 STEROL DESATURASE FATTY ACID HYDROXYLASE DOMAIN-CONTAINING PROTEIN 2 oxidoreductase activity#GO:0016491;monooxygenase activity#GO:0004497;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705 lipid metabolic process#GO:0006629;metabolic process#GO:0008152;sterol metabolic process#GO:0016125;steroid biosynthetic process#GO:0006694;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;sterol biosynthetic process#GO:0016126;steroid metabolic process#GO:0008202;lipid biosynthetic process#GO:0008610 membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;membrane#GO:0016020 oxidase#PC00175 HUMAN|HGNC=18502|UniProtKB=Q9BQ87 Q9BQ87 TBL1Y PTHR22846:SF73 WD40 REPEAT PROTEIN F-BOX-LIKE_WD REPEAT-CONTAINING PROTEIN TBL1Y transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;nucleic acid binding#GO:0003676;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of macromolecule metabolic process#GO:0010605;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;membrane-enclosed lumen#GO:0031974;histone deacetylase complex#GO:0000118;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;transcription regulator complex#GO:0005667;transcription repressor complex#GO:0017053 Wnt signaling pathway#P00057>Ebi#P01453 HUMAN|HGNC=29823|UniProtKB=P14649 P14649 MYL6B PTHR23048:SF5 MYOSIN LIGHT CHAIN 1, 3 MYOSIN LIGHT CHAIN 6B microfilament motor activity#GO:0000146;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543;cytoskeletal motor activity#GO:0003774;structural molecule activity#GO:0005198;isomerase activity#GO:0016853;polypeptide conformation or assembly isomerase activity#GO:0120544;ATP-dependent activity#GO:0140657 intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;myosin complex#GO:0016459;actin cytoskeleton#GO:0015629;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=12029|UniProtKB=P01848 P01848 TRAC PTHR19433:SF72 T-CELL RECEPTOR ALPHA CHAIN V REGION-RELATED T CELL RECEPTOR ALPHA CHAIN MC.7.G5-RELATED response to biotic stimulus#GO:0009607;response to bacterium#GO:0009617;response to other organism#GO:0051707;response to external stimulus#GO:0009605;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=9117|UniProtKB=P02689 P02689 PMP2 PTHR11955:SF64 FATTY ACID BINDING PROTEIN MYELIN P2 PROTEIN fatty acid binding#GO:0005504;lipid binding#GO:0008289;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;anion binding#GO:0043168;carboxylic acid binding#GO:0031406;organic acid binding#GO:0043177 lipid transport#GO:0006869;macromolecule localization#GO:0033036;fatty acid transport#GO:0015908;localization#GO:0051179;establishment of localization#GO:0051234;monocarboxylic acid transport#GO:0015718;lipid localization#GO:0010876;organic acid transport#GO:0015849;transport#GO:0006810;carboxylic acid transport#GO:0046942 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;cytosol#GO:0005829 transfer/carrier protein#PC00219 HUMAN|HGNC=9220|UniProtKB=Q15319 Q15319 POU4F3 PTHR11636:SF43 POU DOMAIN POU DOMAIN, CLASS 4, TRANSCRIPTION FACTOR 3 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=15807|UniProtKB=Q9H4Z2 Q9H4Z2 ZNF335 PTHR24403:SF36 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 335 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;regulation of nervous system development#GO:0051960;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of neurogenesis#GO:0050767;positive regulation of neurogenesis#GO:0050769;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of cell differentiation#GO:0045595;developmental process#GO:0032502;positive regulation of developmental process#GO:0051094;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of cell development#GO:0060284;positive regulation of cellular process#GO:0048522;epigenetic regulation of gene expression#GO:0040029;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;chromatin organization#GO:0006325;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;brain development#GO:0007420;regulation of nucleobase-containing compound metabolic process#GO:0019219;animal gross anatomical part developmental process#GO:0160108;positive regulation of multicellular organismal process#GO:0051240;regulation of multicellular organismal development#GO:2000026;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;chromatin remodeling#GO:0006338;central nervous system development#GO:0007417;positive regulation of nervous system development#GO:0051962;positive regulation of cell differentiation#GO:0045597;animal organ development#GO:0048513;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;nervous system development#GO:0007399;head development#GO:0060322;regulation of multicellular organismal process#GO:0051239;positive regulation of cell development#GO:0010720 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=29797|UniProtKB=Q8NFH5 Q8NFH5 NUP35 PTHR21527:SF6 NUCLEOPORIN NUP35 NUCLEOPORIN NUP35 structural constituent of nuclear pore#GO:0017056;structural molecule activity#GO:0005198;lipid binding#GO:0008289;binding#GO:0005488;phospholipid binding#GO:0005543 cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;protein localization to nucleus#GO:0034504;macromolecule localization#GO:0033036;organelle organization#GO:0006996;import into nucleus#GO:0051170;transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;protein-containing complex organization#GO:0043933;intracellular protein localization#GO:0008104;nucleus organization#GO:0006997;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;protein localization to organelle#GO:0033365;nucleocytoplasmic transport#GO:0006913;protein transport#GO:0015031;protein import into nucleus#GO:0006606;nuclear transport#GO:0051169;nuclear pore organization#GO:0006999;cellular localization#GO:0051641;NLS-bearing protein import into nucleus#GO:0006607;localization#GO:0051179 organelle envelope#GO:0031967;nucleus#GO:0005634;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;nuclear pore#GO:0005643;membrane-bounded organelle#GO:0043227 transporter#PC00227 HUMAN|HGNC=10803|UniProtKB=P35247 P35247 SFTPD PTHR24024:SF15 PULMONARY SURFACTANT-ASSOCIATED PROTEIN A PULMONARY SURFACTANT-ASSOCIATED PROTEIN D signaling receptor activity#GO:0038023;pattern recognition receptor activity#GO:0038187;molecular transducer activity#GO:0060089 regulation of transport#GO:0051049;regulation of localization#GO:0032879;humoral immune response#GO:0006959;immune effector process#GO:0002252;regulation of endocytosis#GO:0030100;defense response to other organism#GO:0098542;response to stress#GO:0006950;positive regulation of immune system process#GO:0002684;response to biotic stimulus#GO:0009607;activation of immune response#GO:0002253;positive regulation of transport#GO:0051050;positive regulation of biological process#GO:0048518;defense response to symbiont#GO:0140546;immune system process#GO:0002376;positive regulation of cellular component organization#GO:0051130;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;regulation of biological process#GO:0050789;innate immune response#GO:0045087;defense response#GO:0006952;response to external stimulus#GO:0009605;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;positive regulation of endocytosis#GO:0045807;positive regulation of response to stimulus#GO:0048584;response to other organism#GO:0051707;biological regulation#GO:0065007;positive regulation of cellular process#GO:0048522;immune response#GO:0006955;complement activation#GO:0006956;regulation of immune response#GO:0050776;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;response to external biotic stimulus#GO:0043207 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 structural protein#PC00211;surfactant#PC00212 HUMAN|HGNC=3120|UniProtKB=O75461 O75461 E2F6 PTHR12081:SF19 TRANSCRIPTION FACTOR E2F TRANSCRIPTION FACTOR E2F6 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 helix-turn-helix transcription factor#PC00116;gene-specific transcriptional regulator#PC00264;winged helix/forkhead transcription factor#PC00246 HUMAN|HGNC=30072|UniProtKB=Q8N6Q3 Q8N6Q3 CD177 PTHR16529:SF8 CD177 ANTIGEN CD177 ANTIGEN plasma membrane raft#GO:0044853;membrane microdomain#GO:0098857;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;plasma membrane#GO:0005886;membrane raft#GO:0045121;membrane#GO:0016020;cell periphery#GO:0071944 HUMAN|HGNC=16810|UniProtKB=P57771 P57771 RGS8 PTHR10845:SF147 REGULATOR OF G PROTEIN SIGNALING REGULATOR OF G PROTEIN SIGNALING 8 enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772 negative regulation of biological process#GO:0048519;negative regulation of G protein-coupled receptor signaling pathway#GO:0045744;regulation of biological process#GO:0050789;negative regulation of response to stimulus#GO:0048585;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;negative regulation of signal transduction#GO:0009968;negative regulation of signaling#GO:0023057;negative regulation of cellular process#GO:0048523;regulation of G protein-coupled receptor signaling pathway#GO:0008277;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;negative regulation of cell communication#GO:0010648 plasma membrane#GO:0005886;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;cytoplasmic side of membrane#GO:0098562;cytoplasmic side of plasma membrane#GO:0009898;membrane#GO:0016020 GTPase-activating protein#PC00257 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>RGS#P00704;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>RGS#P00731 HUMAN|HGNC=18911|UniProtKB=Q9BYQ6 Q9BYQ6 KRTAP4-11 PTHR23262:SF183 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 4-11-RELATED multicellular organismal process#GO:0032501 structural protein#PC00211 HUMAN|HGNC=10378|UniProtKB=P52815 P52815 MRPL12 PTHR45987:SF29 39S RIBOSOMAL PROTEIN L12 LARGE RIBOSOMAL SUBUNIT PROTEIN BL12M RNA binding#GO:0003723;structural molecule activity#GO:0005198;nucleic acid binding#GO:0003676;binding#GO:0005488;structural constituent of ribosome#GO:0003735;mRNA binding#GO:0003729 translation#GO:0006412;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein biosynthetic process#GO:0160307 membrane-enclosed lumen#GO:0031974;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;membraneless organelle#GO:0043228;mitochondrial large ribosomal subunit#GO:0005762;mitochondrion#GO:0005739;ribosome#GO:0005840;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;large ribosomal subunit#GO:0015934;membrane-bounded organelle#GO:0043227;mitochondrial ribosome#GO:0005761;intracellular anatomical structure#GO:0005622;organellar ribosome#GO:0000313 ribosomal protein#PC00202 HUMAN|HGNC=952|UniProtKB=Q99728 Q99728 BARD1 PTHR24171:SF8 ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1 HUMAN|HGNC=4378|UniProtKB=P49915 P49915 GMPS PTHR11922:SF6 GMP SYNTHASE-RELATED GMP SYNTHASE [GLUTAMINE-HYDROLYZING] ligase activity, forming carbon-nitrogen bonds#GO:0016879;ligase activity#GO:0016874;catalytic activity#GO:0003824 purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;nucleoside phosphate metabolic process#GO:0006753;nucleoside monophosphate metabolic process#GO:0009123;purine ribonucleoside monophosphate metabolic process#GO:0009167;small molecule metabolic process#GO:0044281;ribonucleotide metabolic process#GO:0009259;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;nucleoside monophosphate biosynthetic process#GO:0009124;nucleotide biosynthetic process#GO:0009165;organophosphate biosynthetic process#GO:0090407;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;carbohydrate derivative metabolic process#GO:1901135;ribose phosphate biosynthetic process#GO:0046390;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;purine nucleoside monophosphate metabolic process#GO:0009126;nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative biosynthetic process#GO:1901137;nucleoside phosphate biosynthetic process#GO:1901293 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 ligase#PC00142 De novo purine biosynthesis#P02738>GMP synthase#P02899 HUMAN|Gene=DUTL_HUMAN|UniProtKB=Q6ZN92 Q6ZN92 PTHR11241:SF12 DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE INACTIVE DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE-LIKE PROTEIN FLJ16323-RELATED hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;nucleoside triphosphate diphosphatase activity#GO:0047429;ion binding#GO:0043167;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;small molecule binding#GO:0036094;cation binding#GO:0043169;magnesium ion binding#GO:0000287;hydrolase activity#GO:0016787;metal ion binding#GO:0046872 nucleoside monophosphate biosynthetic process#GO:0009124;nucleotide metabolic process#GO:0009117;organophosphate catabolic process#GO:0046434;organophosphate biosynthetic process#GO:0090407;nucleotide biosynthetic process#GO:0009165;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;nucleoside phosphate catabolic process#GO:1901292;nucleoside monophosphate metabolic process#GO:0009123;nucleoside phosphate metabolic process#GO:0006753;carbohydrate derivative catabolic process#GO:1901136;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleotide catabolic process#GO:0009166;nucleoside phosphate biosynthetic process#GO:1901293;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;organophosphate metabolic process#GO:0019637;nucleobase-containing compound catabolic process#GO:0034655;carbohydrate derivative metabolic process#GO:1901135;pyrimidine-containing compound metabolic process#GO:0072527;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058 phosphatase#PC00181;hydrolase#PC00121 HUMAN|HGNC=13324|UniProtKB=Q9C086 Q9C086 INO80B PTHR21561:SF12 INO80 COMPLEX SUBUNIT B INO80 COMPLEX SUBUNIT B protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;membrane-enclosed lumen#GO:0031974;chromatin#GO:0000785;nucleus#GO:0005634;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;Ino80 complex#GO:0031011;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;organelle lumen#GO:0043233;SWI/SNF superfamily-type complex#GO:0070603;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;INO80-type complex#GO:0097346;intracellular organelle lumen#GO:0070013;ATPase complex#GO:1904949;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 HUMAN|HGNC=29525|UniProtKB=Q8NBF1 Q8NBF1 GLIS1 PTHR45718:SF3 TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS ZINC FINGER PROTEIN GLIS1 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HUMAN|HGNC=10907|UniProtKB=P49279 P49279 SLC11A1 PTHR11706:SF52 SOLUTE CARRIER PROTEIN FAMILY 11 MEMBER NATURAL RESISTANCE-ASSOCIATED MACROPHAGE PROTEIN 1 iron ion transmembrane transporter activity#GO:0005381;monoatomic cation transmembrane transporter activity#GO:0008324;transition metal ion transmembrane transporter activity#GO:0046915;metal cation:proton antiporter activity#GO:0051139;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;antiporter activity#GO:0015297;proton transmembrane transporter activity#GO:0015078;secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;establishment of localization#GO:0051234;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;intracellular monoatomic cation homeostasis#GO:0030003;iron ion transmembrane transport#GO:0034755;intracellular iron ion homeostasis#GO:0006879;homeostatic process#GO:0042592;metal ion transport#GO:0030001;intracellular monoatomic ion homeostasis#GO:0006873;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;inorganic ion homeostasis#GO:0098771;transition metal ion transport#GO:0000041;iron ion transport#GO:0006826 vesicle membrane#GO:0012506;membrane#GO:0016020;cell periphery#GO:0071944;lysosomal membrane#GO:0005765;cytoplasmic vesicle membrane#GO:0030659;phagocytic vesicle#GO:0045335;endomembrane system#GO:0012505;plasma membrane#GO:0005886;vacuole#GO:0005773;cytoplasm#GO:0005737;lytic vacuole#GO:0000323;vacuolar membrane#GO:0005774;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;lytic vacuole membrane#GO:0098852;intracellular vesicle#GO:0097708;vesicle#GO:0031982;lysosome#GO:0005764;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;endosome membrane#GO:0010008;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;endocytic vesicle#GO:0030139;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410 transporter#PC00227;secondary carrier transporter#PC00258 HUMAN|HGNC=9156|UniProtKB=P54315 P54315 PNLIPRP1 PTHR11610:SF108 LIPASE INACTIVE PANCREATIC LIPASE-RELATED PROTEIN 1 hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;lipase activity#GO:0016298;catalytic activity#GO:0003824 primary metabolic process#GO:0044238;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;cellular process#GO:0009987;lipid catabolic process#GO:0016042;catabolic process#GO:0009056 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 metabolite interconversion enzyme#PC00262;lipase#PC00143;hydrolase#PC00121 HUMAN|HGNC=21945|UniProtKB=A8MWY0 A8MWY0 ELAPOR2 PTHR22727:SF3 PROTEIN CBG13728 ENDOSOME_LYSOSOME-ASSOCIATED APOPTOSIS AND AUTOPHAGY REGULATOR FAMILY MEMBER 2 regulation of response to stimulus#GO:0048583;positive regulation of BMP signaling pathway#GO:0030513;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of BMP signaling pathway#GO:0030510;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cellular response to growth factor stimulus#GO:0090287;positive regulation of response to stimulus#GO:0048584;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092;regulation of cell communication#GO:0010646;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;membrane#GO:0016020 HUMAN|HGNC=21150|UniProtKB=Q96EQ8 Q96EQ8 RNF125 PTHR46016:SF2 ZINC FINGER, RING/FYVE/PHD-TYPE E3 UBIQUITIN-PROTEIN LIGASE RNF125 aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746 post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;catabolic process#GO:0009056;primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;protein modification by small protein conjugation or removal#GO:0070647;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;organelle membrane#GO:0031090;endoplasmic reticulum protein-containing complex#GO:0140534;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasm#GO:0005737;membrane#GO:0016020 HUMAN|HGNC=3528|UniProtKB=P00742 P00742 F10 PTHR24278:SF28 COAGULATION FACTOR COAGULATION FACTOR X serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;serine-type peptidase activity#GO:0008236 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 serine protease#PC00203 Blood coagulation#P00011>FXa#P00445;Blood coagulation#P00011>FX#P00430 HUMAN|HGNC=4886|UniProtKB=Q30201 Q30201 HFE PTHR16675:SF172 MHC CLASS I-RELATED HEREDITARY HEMOCHROMATOSIS PROTEIN signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515 immune system process#GO:0002376;regulation of localization#GO:0032879;regulation of transport#GO:0051049;response to stress#GO:0006950;response to starvation#GO:0042594;response to nutrient levels#GO:0031667;regulation of biological process#GO:0050789;immune response#GO:0006955;regulation of monoatomic ion transport#GO:0043269;response to stimulus#GO:0050896;regulation of metal ion transport#GO:0010959;biological regulation#GO:0065007 side of membrane#GO:0098552;extracellular region#GO:0005576;external side of plasma membrane#GO:0009897;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 major histocompatibility complex protein#PC00149;defense/immunity protein#PC00090 HUMAN|HGNC=20993|UniProtKB=Q9H446 Q9H446 RWDD1 PTHR12292:SF9 RWD DOMAIN-CONTAINING PROTEIN RWD DOMAIN-CONTAINING PROTEIN 1 cellular process#GO:0009987;nuclear receptor-mediated steroid hormone signaling pathway#GO:0030518;signal transduction#GO:0007165;response to hormone#GO:0009725;biological regulation#GO:0065007;response to lipid#GO:0033993;cellular response to lipid#GO:0071396;response to chemical#GO:0042221;nuclear receptor-mediated signaling pathway#GO:0141193;cellular response to steroid hormone stimulus#GO:0071383;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;steroid hormone receptor signaling pathway#GO:0043401;response to endogenous stimulus#GO:0009719;signaling#GO:0023052;intracellular receptor signaling pathway#GO:0030522;regulation of cellular process#GO:0050794;cellular response to hormone stimulus#GO:0032870;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;response to steroid hormone#GO:0048545;cellular response to chemical stimulus#GO:0070887;intracellular signal transduction#GO:0035556;hormone-mediated signaling pathway#GO:0009755;cell communication#GO:0007154 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=20566|UniProtKB=Q7L0J3 Q7L0J3 SV2A PTHR23511:SF11 SYNAPTIC VESICLE GLYCOPROTEIN 2 SYNAPTIC VESICLE GLYCOPROTEIN 2A synaptic vesicle cycle#GO:0099504;transport#GO:0006810;establishment of localization#GO:0051234;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;neurotransmitter secretion#GO:0007269;signal release#GO:0023061;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154;localization#GO:0051179;secretion#GO:0046903;signal release from synapse#GO:0099643;chemical synaptic transmission#GO:0007268;anterograde trans-synaptic signaling#GO:0098916;regulated exocytosis#GO:0045055;exocytic process#GO:0140029;cellular component organization or biogenesis#GO:0071840;vesicle-mediated transport in synapse#GO:0099003;exocytosis#GO:0006887;protein-containing complex organization#GO:0043933;cellular component biogenesis#GO:0044085;synaptic signaling#GO:0099536;establishment of localization in cell#GO:0051649;synaptic vesicle exocytosis#GO:0016079;cellular process#GO:0009987;cellular component assembly#GO:0022607;vesicle-mediated transport#GO:0016192;neurotransmitter transport#GO:0006836;cellular localization#GO:0051641;secretion by cell#GO:0032940;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;protein-containing complex assembly#GO:0065003;export from cell#GO:0140352;signaling#GO:0023052 cell junction#GO:0030054;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;transport vesicle membrane#GO:0030658;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;transport vesicle#GO:0030133;cytoplasm#GO:0005737;secretory vesicle#GO:0099503;membrane#GO:0016020;vesicle membrane#GO:0012506;presynapse#GO:0098793;neuron projection#GO:0043005;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;cell projection#GO:0042995;intracellular vesicle#GO:0097708;synaptic vesicle#GO:0008021;synaptic vesicle membrane#GO:0030672;vesicle#GO:0031982 HUMAN|HGNC=8672|UniProtKB=Q9UN73 Q9UN73 PCDHA6 PTHR24028:SF305 CADHERIN-87A PROTOCADHERIN ALPHA-6-RELATED cell adhesion#GO:0007155;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;cadherin#PC00057 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HUMAN|HGNC=32545|UniProtKB=P0C7T8 P0C7T8 TMEM253 PTHR37359:SF1 TRANSMEMBRANE PROTEIN 253 TRANSMEMBRANE PROTEIN 253 HUMAN|HGNC=9083|UniProtKB=O60568 O60568 PLOD3 PTHR10730:SF7 PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER MULTIFUNCTIONAL PROCOLLAGEN LYSINE HYDROXYLASE AND GLYCOSYLTRANSFERASE LH3 hexosyltransferase activity#GO:0016758;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824;transferase activity#GO:0016740;glycosyltransferase activity#GO:0016757;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;glucosyltransferase activity#GO:0046527;dioxygenase activity#GO:0051213 external encapsulating structure organization#GO:0045229;collagen fibril organization#GO:0030199;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043;extracellular structure organization#GO:0043062 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;Golgi apparatus#GO:0005794;extracellular region#GO:0005576;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 protein modifying enzyme#PC00260 HUMAN|HGNC=11510|UniProtKB=Q8N9I0 Q8N9I0 SYT2 PTHR10024:SF223 SYNAPTOTAGMIN SYNAPTOTAGMIN-2 binding#GO:0005488;phospholipid binding#GO:0005543;SNARE binding#GO:0000149;molecular sensor activity#GO:0140299;molecular function regulator activity#GO:0098772;lipid binding#GO:0008289;protein binding#GO:0005515 regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;regulation of synaptic vesicle exocytosis#GO:2000300;signaling#GO:0023052;export from cell#GO:0140352;regulation of neurotransmitter secretion#GO:0046928;regulation of cellular component organization#GO:0051128;regulation of signaling#GO:0023051;positive regulation of cellular component organization#GO:0051130;regulation of neurotransmitter transport#GO:0051588;regulation of secretion by cell#GO:1903530;secretion by cell#GO:0032940;cellular localization#GO:0051641;positive regulation of organelle organization#GO:0010638;cellular process#GO:0009987;synaptic vesicle exocytosis#GO:0016079;positive regulation of biological process#GO:0048518;positive regulation of transport#GO:0051050;establishment of localization in cell#GO:0051649;synaptic signaling#GO:0099536;neurotransmitter transport#GO:0006836;regulation of trans-synaptic signaling#GO:0099177;vesicle-mediated transport#GO:0016192;regulated exocytosis#GO:0045055;regulation of transport#GO:0051049;regulation of localization#GO:0032879;positive regulation of vesicle fusion#GO:0031340;exocytosis#GO:0006887;vesicle-mediated transport in synapse#GO:0099003;signal release from synapse#GO:0099643;chemical synaptic transmission#GO:0007268;regulation of cell communication#GO:0010646;modulation of chemical synaptic transmission#GO:0050804;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;trans-synaptic signaling#GO:0099537;signal release#GO:0023061;regulation of exocytosis#GO:0017157;secretion#GO:0046903;regulation of secretion#GO:0051046;localization#GO:0051179;cell communication#GO:0007154;positive regulation of cellular process#GO:0048522;neurotransmitter secretion#GO:0007269;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;transport#GO:0006810;synaptic vesicle cycle#GO:0099504;establishment of localization#GO:0051234 organelle membrane#GO:0031090;transport vesicle#GO:0030133;endomembrane system#GO:0012505;transport vesicle membrane#GO:0030658;plasma membrane#GO:0005886;vesicle membrane#GO:0012506;membrane#GO:0016020;cell periphery#GO:0071944;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;axon#GO:0030424;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;synaptic vesicle membrane#GO:0030672;vesicle#GO:0031982;synaptic vesicle#GO:0008021;cell junction#GO:0030054;bounding membrane of organelle#GO:0098588;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;secretory vesicle#GO:0099503;presynapse#GO:0098793;neuron projection#GO:0043005;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;intracellular vesicle#GO:0097708 membrane trafficking regulatory protein#PC00151 Synaptic vesicle trafficking#P05734>Synaptotagmin#P05769 HUMAN|HGNC=7751|UniProtKB=Q99435 Q99435 NELL2 PTHR24042:SF0 NEL HOMOLOG PROTEIN KINASE C-BINDING PROTEIN NELL2 carbohydrate derivative binding#GO:0097367;heparin binding#GO:0008201;protein binding#GO:0005515;binding#GO:0005488;kinase binding#GO:0019900;glycosaminoglycan binding#GO:0005539;enzyme binding#GO:0019899;protein kinase binding#GO:0019901 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 calcium-binding protein#PC00060 HUMAN|HGNC=20499|UniProtKB=Q9H9P8 Q9H9P8 L2HGDH PTHR43104:SF2 L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614 small molecule metabolic process#GO:0044281;cellular process#GO:0009987;metabolic process#GO:0008152 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 dehydrogenase#PC00092 HUMAN|HGNC=30521|UniProtKB=Q96NT5 Q96NT5 SLC46A1 PTHR23507:SF2 ZGC:174356 PROTON-COUPLED FOLATE TRANSPORTER transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;cellular process#GO:0009987;transport#GO:0006810 cellular anatomical structure#GO:0110165;membrane#GO:0016020 HUMAN|HGNC=6018|UniProtKB=P05231 P05231 IL6 PTHR48494:SF1 INTERLEUKIN-6 INTERLEUKIN-6 molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;signaling receptor regulator activity#GO:0030545;cytokine activity#GO:0005125;receptor ligand activity#GO:0048018 cell communication#GO:0007154;response to peptide#GO:1901652;cytokine-mediated signaling pathway#GO:0019221;inflammatory response#GO:0006954;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;defense response#GO:0006952;cell surface receptor signaling pathway#GO:0007166;response to cytokine#GO:0034097;response to chemical#GO:0042221;biological regulation#GO:0065007;response to stress#GO:0006950;cellular process#GO:0009987;signal transduction#GO:0007165 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 Interleukin signaling pathway#P00036>Interleukin#P00970;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>IL2#P00870 HUMAN|HGNC=20100|UniProtKB=A0A1B0GTZ2 A0A1B0GTZ2 CCDC196 PTHR37863:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 196-RELATED COILED-COIL DOMAIN-CONTAINING PROTEIN 196 HUMAN|HGNC=18474|UniProtKB=Q9ULC8 Q9ULC8 ZDHHC8 PTHR12349:SF1 ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2 PALMITOYLTRANSFERASE ZDHHC8 acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740;palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 regulation of localization#GO:0032879;biological regulation#GO:0065007;regulation of transport#GO:0051049;regulation of biological process#GO:0050789;positive regulation of biological process#GO:0048518;positive regulation of transport#GO:0051050 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 HUMAN|HGNC=6617|UniProtKB=P38571 P38571 LIPA PTHR11005:SF26 LYSOSOMAL ACID LIPASE-RELATED LYSOSOMAL ACID LIPASE_CHOLESTERYL ESTER HYDROLASE lipase activity#GO:0016298;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787 primary metabolic process#GO:0044238;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;cellular process#GO:0009987 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229 lipase#PC00143;hydrolase#PC00121 Androgen/estrogene/progesterone biosynthesis#P02727>Cholesterol esterase#P02830 HUMAN|HGNC=32258|UniProtKB=A6NDY2 A6NDY2 FAM90A10 PTHR16035:SF14 PROTEIN FAM90A1 PROTEIN FAM90A10-RELATED HUMAN|HGNC=24941|UniProtKB=P51991 P51991 HNRNPA3 PTHR48026:SF12 HOMOLOGOUS TO DROSOPHILA SQD (SQUID) PROTEIN HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A3 nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;mRNA 3'-UTR binding#GO:0003730;RNA binding#GO:0003723 mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA splicing, via spliceosome#GO:0000398;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070 nucleus#GO:0005634;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;catalytic step 2 spliceosome#GO:0071013 RNA metabolism protein#PC00031;RNA processing factor#PC00147 HUMAN|HGNC=12496|UniProtKB=Q05086 Q05086 UBE3A PTHR45622:SF82 UBIQUITIN-PROTEIN LIGASE E3A-RELATED UBIQUITIN-PROTEIN LIGASE E3A ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;protein modification process#GO:0036211;primary metabolic process#GO:0044238;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;regulation of biological process#GO:0050789;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;regulation of protein catabolic process#GO:0042176;protein modification by small protein conjugation or removal#GO:0070647;post-translational protein modification#GO:0043687;biological regulation#GO:0065007;protein ubiquitination#GO:0016567;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;regulation of catabolic process#GO:0009894;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;metabolic process#GO:0008152 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234 Ubiquitin proteasome pathway#P00060>E3#P01490 HUMAN|HGNC=15661|UniProtKB=Q7RTX0 Q7RTX0 TAS1R3 PTHR24061:SF435 CALCIUM-SENSING RECEPTOR-RELATED TASTE RECEPTOR TYPE 1 MEMBER 3 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;taste receptor activity#GO:0008527;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089 system process#GO:0003008;multicellular organismal process#GO:0032501;sensory perception#GO:0007600;nervous system process#GO:0050877;sensory perception of taste#GO:0050909;sensory perception of chemical stimulus#GO:0007606 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=2156|UniProtKB=Q99439 Q99439 CNN2 PTHR47385:SF7 CALPONIN CALPONIN-2 protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin filament binding#GO:0051015;actin binding#GO:0003779 cellular component organization or biogenesis#GO:0071840;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;actin filament-based process#GO:0030029;actin cytoskeleton organization#GO:0030036;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;actin cytoskeleton#GO:0015629;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232 HUMAN|HGNC=14562|UniProtKB=O15155 O15155 BET1 PTHR12791:SF53 GOLGI SNARE BET1-RELATED BET1 HOMOLOG SNAP receptor activity#GO:0005484;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 vesicle organization#GO:0016050;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;Golgi vesicle transport#GO:0048193;transport#GO:0006810;intracellular transport#GO:0046907;organelle membrane fusion#GO:0090174;membrane organization#GO:0061024;endomembrane system organization#GO:0010256;vesicle-mediated transport#GO:0016192;organelle fusion#GO:0048284;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;organelle organization#GO:0006996;membrane fusion#GO:0061025;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;localization#GO:0051179;vesicle fusion#GO:0006906;Golgi organization#GO:0007030;cellular component organization#GO:0016043 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;SNARE complex#GO:0031201;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;membrane#GO:0016020;membrane protein complex#GO:0098796 SNARE protein#PC00034 HUMAN|HGNC=9061|UniProtKB=Q8N3E9 Q8N3E9 PLCD3 PTHR10336:SF33 PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN 1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-3 phospholipase activity#GO:0120569;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;glycerophospholipase activity#GO:0004620;phosphoric ester hydrolase activity#GO:0042578;phosphoric diester hydrolase activity#GO:0008081;lipase activity#GO:0016298;hydrolase activity#GO:0016787 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 hydrolase#PC00121;lipase#PC00143;phospholipase#PC00186;metabolite interconversion enzyme#PC00262 5HT2 type receptor mediated signaling pathway#P04374>PLC#P04412;Oxytocin receptor mediated signaling pathway#P04391>PLC beta#P04530;Histamine H1 receptor mediated signaling pathway#P04385>PLC#P04484;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PLCbetagamma#P00874;Thyrotropin-releasing hormone receptor signaling pathway#P04394>PLC#P04581 HUMAN|HGNC=174|UniProtKB=Q13705 Q13705 ACVR2B PTHR23255:SF70 TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II ACTIVIN RECEPTOR TYPE-2B transmembrane receptor protein kinase activity#GO:0019199;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;activin binding#GO:0048185;kinase activity#GO:0016301;transferase activity#GO:0016740;protein kinase activity#GO:0004672;protein-containing complex binding#GO:0044877;transmembrane receptor protein serine/threonine kinase activity#GO:0004675;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane signaling receptor activity#GO:0004888;protein serine/threonine kinase activity#GO:0004674;binding#GO:0005488 pattern specification process#GO:0007389;activin receptor signaling pathway#GO:0032924;cellular response to growth factor stimulus#GO:0071363;cell communication#GO:0007154;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to endogenous stimulus#GO:0009719;signaling#GO:0023052;cellular response to endogenous stimulus#GO:0071495;response to growth factor#GO:0070848;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;developmental process#GO:0032502;cell surface receptor signaling pathway#GO:0007166;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;multicellular organism development#GO:0007275;signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;multicellular organismal process#GO:0032501 protein kinase complex#GO:1902911;serine/threonine protein kinase complex#GO:1902554;transferase complex, transferring phosphorus-containing groups#GO:0061695;signaling receptor complex#GO:0043235;catalytic complex#GO:1902494;transferase complex#GO:1990234;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797 serine/threonine protein kinase receptor#PC00205 TGF-beta signaling pathway#P00052>TGFbetareceptors#P01283;Gonadotropin-releasing hormone receptor pathway#P06664>ActRII/IIB#P06780;TGF-beta signaling pathway#P00052>TGFbetareceptor II#P01277 HUMAN|HGNC=6663|UniProtKB=P23490 P23490 LORICRIN PTHR39228:SF2 LORICRIN LORICRIN structural molecule activity#GO:0005198 cell periphery#GO:0071944;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 HUMAN|HGNC=1121|UniProtKB=P35070 P35070 BTC PTHR10740:SF3 TRANSFORMING GROWTH FACTOR ALPHA PROBETACELLULIN growth factor activity#GO:0008083;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;growth factor receptor binding#GO:0070851;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;signaling receptor binding#GO:0005102;binding#GO:0005488;molecular function activator activity#GO:0140677;protein binding#GO:0005515 regulation of mitotic nuclear division#GO:0007088;cell surface receptor signaling pathway#GO:0007166;positive regulation of mitotic nuclear division#GO:0045840;positive regulation of cell cycle#GO:0045787;regulation of nuclear division#GO:0051783;regulation of cell cycle process#GO:0010564;biological regulation#GO:0065007;epidermal growth factor receptor signaling pathway#GO:0007173;cellular process#GO:0009987;ERBB signaling pathway#GO:0038127;regulation of mitotic cell cycle#GO:0007346;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of cellular process#GO:0048522;positive regulation of organelle organization#GO:0010638;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;positive regulation of cellular component organization#GO:0051130;signaling#GO:0023052;regulation of cell cycle#GO:0051726;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of cellular component organization#GO:0051128;cellular response to stimulus#GO:0051716;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;positive regulation of cell cycle process#GO:0090068;positive regulation of cell population proliferation#GO:0008284 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 growth factor#PC00112 EGF receptor signaling pathway#P00018>EGF#P00549 HUMAN|HGNC=17904|UniProtKB=Q9NRR4 Q9NRR4 DROSHA PTHR11207:SF37 RIBONUCLEASE III RIBONUCLEASE 3 RNA nuclease activity#GO:0004540;endonuclease activity#GO:0004519;catalytic activity, acting on RNA#GO:0140098;RNA endonuclease activity#GO:0004521;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;RNA binding#GO:0003723;hydrolase activity#GO:0016787;nuclease activity#GO:0004518;binding#GO:0005488;nucleic acid binding#GO:0003676;double-stranded RNA binding#GO:0003725 regulatory ncRNA-mediated gene silencing#GO:0031047;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulatory ncRNA processing#GO:0070918;macromolecule biosynthetic process#GO:0009059;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;biosynthetic process#GO:0009058;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;pre-miRNA processing#GO:0031054;regulation of macromolecule metabolic process#GO:0060255;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;primary miRNA processing#GO:0031053;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;RNA processing#GO:0006396;gene expression#GO:0010467;miRNA processing#GO:0035196;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892 intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;endonuclease complex#GO:1905348;endoribonuclease complex#GO:1902555 RNA metabolism protein#PC00031;endoribonuclease#PC00094 HUMAN|HGNC=6239|UniProtKB=Q9UK17 Q9UK17 KCND3 PTHR11537:SF182 VOLTAGE-GATED POTASSIUM CHANNEL A-TYPE VOLTAGE-GATED POTASSIUM CHANNEL KCND3 passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261;potassium channel activity#GO:0005267;outward rectifier potassium channel activity#GO:0015271;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic ion channel activity#GO:0005244;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324 transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;action potential#GO:0001508;metal ion transport#GO:0030001;export from cell#GO:0140352;transport#GO:0006810;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;cellular process#GO:0009987;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;potassium ion transmembrane transport#GO:0071805;biological regulation#GO:0065007;monoatomic cation transmembrane transport#GO:0098655 dendritic tree#GO:0097447;dendrite#GO:0030425;postsynaptic membrane#GO:0045211;transmembrane transporter complex#GO:1902495;cell body#GO:0044297;dendritic spine#GO:0043197;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;postsynapse#GO:0098794;cell projection#GO:0042995;neuronal cell body#GO:0043025;neuron spine#GO:0044309;plasma membrane bounded cell projection#GO:0120025;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cation channel complex#GO:0034703;voltage-gated potassium channel complex#GO:0008076;synaptic membrane#GO:0097060;cell junction#GO:0030054;transporter complex#GO:1990351;neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;plasma membrane region#GO:0098590;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991 voltage-gated ion channel#PC00241;ion channel#PC00133 HUMAN|HGNC=4661|UniProtKB=Q9UHL9 Q9UHL9 GTF2IRD1 PTHR46304:SF1 GENERAL TRANSCRIPTION FACTOR II-I REPEAT DOMAIN-CONTAINING PROTEIN 1 GENERAL TRANSCRIPTION FACTOR II-I REPEAT DOMAIN-CONTAINING PROTEIN 1 transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031;general transcription factor#PC00259 HUMAN|HGNC=41989|UniProtKB=A6NJU9 A6NJU9 NPIPB13 PTHR15438:SF5 NUCLEAR PORE COMPLEX INTERACTING PROTEIN NUCLEAR PORE COMPLEX INTERACTING PROTEIN FAMILY MEMBER B3-RELATED HUMAN|HGNC=4013|UniProtKB=Q10981 Q10981 FUT2 PTHR11927:SF2 GALACTOSIDE 2-L-FUCOSYLTRANSFERASE GALACTOSIDE ALPHA-(1,2)-FUCOSYLTRANSFERASE 2 hexosyltransferase activity#GO:0016758;fucosyltransferase activity#GO:0008417;transferase activity#GO:0016740;catalytic activity#GO:0003824;glycosyltransferase activity#GO:0016757 macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;biosynthetic process#GO:0009058;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;protein O-linked glycosylation#GO:0006493;cellular process#GO:0009987 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 glycosyltransferase#PC00111 HUMAN|HGNC=30775|UniProtKB=Q86UP8 Q86UP8 GTF2IRD2 PTHR47831:SF1 GENERAL TRANSCRIPTION FACTOR II-I REPEAT DOMAIN-CONTAINING PROTEIN 2 GENERAL TRANSCRIPTION FACTOR II-I REPEAT DOMAIN-CONTAINING PROTEIN 2A-RELATED nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 general transcription factor#PC00259 HUMAN|HGNC=11300|UniProtKB=P09132 P09132 SRP19 PTHR17453:SF1 SIGNAL RECOGNITION PARTICLE 19 KD PROTEIN SIGNAL RECOGNITION PARTICLE 19 KDA PROTEIN RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 SRP-dependent cotranslational protein targeting to membrane#GO:0006614;protein targeting to membrane#GO:0006612;protein targeting to ER#GO:0045047;protein-containing complex organization#GO:0043933;establishment of protein localization to organelle#GO:0072594;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;establishment of protein localization#GO:0045184;cellular process#GO:0009987;establishment of protein localization to membrane#GO:0090150;cellular component biogenesis#GO:0044085;establishment of protein localization to endoplasmic reticulum#GO:0072599;cellular component assembly#GO:0022607;localization within membrane#GO:0051668;localization#GO:0051179;cellular localization#GO:0051641;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;protein targeting#GO:0006605 ribonucleoprotein complex#GO:1990904;cytoplasm#GO:0005737;signal recognition particle, endoplasmic reticulum targeting#GO:0005786;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 transporter#PC00227;primary active transporter#PC00068 HUMAN|HGNC=6250|UniProtKB=O95259 O95259 KCNH1 PTHR10217:SF530 VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL VOLTAGE-GATED DELAYED RECTIFIER POTASSIUM CHANNEL KCNH1 potassium channel activity#GO:0005267;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;transporter activity#GO:0005215;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 metal ion transport#GO:0030001;homeostatic process#GO:0042592;intracellular monoatomic ion homeostasis#GO:0006873;regulation of cytosolic calcium ion concentration#GO:0051480;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;calcium ion homeostasis#GO:0055074;inorganic ion homeostasis#GO:0098771;potassium ion transport#GO:0006813;biological regulation#GO:0065007;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;monoatomic ion transmembrane transport#GO:0034220;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;intracellular calcium ion homeostasis#GO:0006874;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;intracellular monoatomic cation homeostasis#GO:0030003 protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane protein complex#GO:0098796;membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;cation channel complex#GO:0034703;voltage-gated potassium channel complex#GO:0008076 ion channel#PC00133;transporter#PC00227 HUMAN|HGNC=34430|UniProtKB=A1IGU5 A1IGU5 ARHGEF37 PTHR22834:SF9 NUCLEAR FUSION PROTEIN FUS2 RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 37 guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=2452|UniProtKB=P48730 P48730 CSNK1D PTHR11909:SF519 CASEIN KINASE-RELATED CASEIN KINASE I ISOFORM DELTA catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 organelle assembly#GO:0070925;regulation of protein catabolic process#GO:0042176;positive regulation of protein catabolic process#GO:0045732;microtubule cytoskeleton organization#GO:0000226;cell communication#GO:0007154;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434;non-motile cilium assembly#GO:1905515;cellular response to stimulus#GO:0051716;positive regulation of ubiquitin-dependent protein catabolic process#GO:2000060;positive regulation of signal transduction#GO:0009967;cell cycle#GO:0007049;regulation of cell communication#GO:0010646;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of response to stimulus#GO:0048583;plasma membrane bounded cell projection assembly#GO:0120031;regulation of catabolic process#GO:0009894;positive regulation of catabolic process#GO:0009896;positive regulation of canonical Wnt signaling pathway#GO:0090263;spindle organization#GO:0007051;regulation of circadian rhythm#GO:0042752;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of response to stimulus#GO:0048584;positive regulation of protein metabolic process#GO:0051247;regulation of signaling#GO:0023051;cilium organization#GO:0044782;positive regulation of signaling#GO:0023056;positive regulation of metabolic process#GO:0009893;cell cycle process#GO:0022402;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;cilium assembly#GO:0060271;membraneless organelle assembly#GO:0140694;positive regulation of proteasomal protein catabolic process#GO:1901800;regulation of Wnt signaling pathway#GO:0030111;signaling#GO:0023052;response to stimulus#GO:0050896;cell projection organization#GO:0030030;chromosome segregation#GO:0007059;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;cell projection assembly#GO:0030031;signal transduction#GO:0007165;spindle assembly#GO:0051225;regulation of canonical Wnt signaling pathway#GO:0060828;regulation of protein metabolic process#GO:0051246;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;positive regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032436;positive regulation of macromolecule metabolic process#GO:0010604;regulation of proteasomal protein catabolic process#GO:0061136;cellular component assembly#GO:0022607;positive regulation of Wnt signaling pathway#GO:0030177 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;spindle microtubule#GO:0005876;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;spindle#GO:0005819;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;nucleus#GO:0005634;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081 non-receptor serine/threonine protein kinase#PC00167 Parkinson disease#P00049>Casein kinase I#P01242;Circadian clock system#P00015>Casein kinase I#P00502;Wnt signaling pathway#P00057>Casein Kinase 1#P01460;CCKR signaling map#P06959>CK1delta/epsilon#P07089 HUMAN|HGNC=26265|UniProtKB=Q5SY16 Q5SY16 NOL9 PTHR12755:SF3 CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P POLYNUCLEOTIDE 5'-HYDROXYL-KINASE NOL9 transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;nucleobase-containing compound kinase activity#GO:0019205;catalytic activity#GO:0003824;phosphotransferase activity, alcohol group as acceptor#GO:0016773 rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000479;cellular component biogenesis#GO:0044085;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;maturation of LSU-rRNA#GO:0000470;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;ribosomal large subunit biogenesis#GO:0042273;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;maturation of 5.8S rRNA#GO:0000460 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 RNA processing factor#PC00147;mRNA polyadenylation factor#PC00146;RNA metabolism protein#PC00031 HUMAN|HGNC=6363|UniProtKB=P20151 P20151 KLK2 PTHR24271:SF94 KALLIKREIN-RELATED KALLIKREIN-2 serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175 metabolic process#GO:0008152;system process#GO:0003008;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059;regulation of blood pressure#GO:0008217;regulation of systemic arterial blood pressure#GO:0003073;biological regulation#GO:0065007;biosynthetic process#GO:0009058;blood circulation#GO:0008015;protein maturation#GO:0051604;gene expression#GO:0010467;multicellular organismal process#GO:0032501;proteolysis#GO:0006508;circulatory system process#GO:0003013;regulation of biological quality#GO:0065008;protein metabolic process#GO:0019538;zymogen activation#GO:0031638;primary metabolic process#GO:0044238 vesicle#GO:0031982;secretory vesicle#GO:0099503;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;extracellular region#GO:0005576;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227 serine protease#PC00203 HUMAN|HGNC=9836|UniProtKB=Q8NFJ5 Q8NFJ5 GPRC5A PTHR14511:SF7 G PROTEIN COUPLED RECEPTOR, CLASS C, GROUP 5 RETINOIC ACID-INDUCED PROTEIN 3 kinase activator activity#GO:0019209;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;enzyme activator activity#GO:0008047;protein kinase activator activity#GO:0030295;protein kinase regulator activity#GO:0019887;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207 extracellular region#GO:0005576;signaling receptor complex#GO:0043235;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;cell periphery#GO:0071944;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HUMAN|HGNC=16901|UniProtKB=Q15772 Q15772 SPEG PTHR47633:SF3 IMMUNOGLOBULIN STRIATED MUSCLE PREFERENTIALLY EXPRESSED PROTEIN KINASE anatomical structure development#GO:0048856;cellular developmental process#GO:0048869;animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502;cell differentiation#GO:0030154;muscle structure development#GO:0061061;muscle cell differentiation#GO:0042692;cellular process#GO:0009987 HUMAN|HGNC=2216|UniProtKB=P25067 P25067 COL8A2 PTHR24023:SF855 COLLAGEN ALPHA COLLAGEN ALPHA-2(VIII) CHAIN structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 extracellular structure organization#GO:0043062;cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;external encapsulating structure organization#GO:0045229 cellular anatomical structure#GO:0110165;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 Integrin signalling pathway#P00034>Collagen#P00922 HUMAN|HGNC=2383|UniProtKB=O43186 O43186 CRX PTHR45793:SF22 HOMEOBOX PROTEIN CONE-ROD HOMEOBOX PROTEIN transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=25589|UniProtKB=Q9NVA2 Q9NVA2 SEPTIN11 PTHR18884:SF48 SEPTIN SEPTIN-11 hydrolase activity, acting on acid anhydrides#GO:0016817;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787 macromolecule localization#GO:0033036;cell cycle#GO:0007049;cell division#GO:0051301;cell cycle process#GO:0022402;cellular process#GO:0009987;localization#GO:0051179;cytoskeleton-dependent cytokinesis#GO:0061640;intracellular protein localization#GO:0008104;cytokinesis#GO:0000910 intracellular membraneless organelle#GO:0043232;cell division site#GO:0032153;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cell cortex#GO:0005938;cell periphery#GO:0071944;microtubule cytoskeleton#GO:0015630;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 cytoskeletal protein#PC00085 HUMAN|HGNC=10457|UniProtKB=O15537 O15537 RS1 PTHR24543:SF295 MULTICOPPER OXIDASE-RELATED RETINOSCHISIN sensory system development#GO:0048880;camera-type eye morphogenesis#GO:0048593;retina development in camera-type eye#GO:0060041;multicellular organismal process#GO:0032501;developmental process#GO:0032502;sensory organ development#GO:0007423;anatomical structure formation involved in morphogenesis#GO:0048646;animal organ development#GO:0048513;multicellular organism development#GO:0007275;anatomical structure morphogenesis#GO:0009653;visual system development#GO:0150063;animal organ morphogenesis#GO:0009887;sensory organ morphogenesis#GO:0090596;animal gross anatomical part developmental process#GO:0160108;camera-type eye development#GO:0043010;eye development#GO:0001654;system development#GO:0048731;anatomical structure development#GO:0048856 cell surface#GO:0009986;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;side of membrane#GO:0098552;extracellular region#GO:0005576;external side of plasma membrane#GO:0009897 oxidoreductase#PC00176 HUMAN|HGNC=6224|UniProtKB=P22460 P22460 KCNA5 PTHR11537:SF250 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 5 channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;potassium channel activity#GO:0005267;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215 metal ion transport#GO:0030001;action potential#GO:0001508;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transmembrane transport#GO:0034220;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;biological regulation#GO:0065007;potassium ion transport#GO:0006813;cellular process#GO:0009987;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;transport#GO:0006810 monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane#GO:0016020;cell-cell junction#GO:0005911;cell periphery#GO:0071944;cell junction#GO:0030054;transporter complex#GO:1990351;cell-cell contact zone#GO:0044291;cation channel complex#GO:0034703;voltage-gated potassium channel complex#GO:0008076;cellular anatomical structure#GO:0110165;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;transmembrane transporter complex#GO:1902495;intercalated disc#GO:0014704;anchoring junction#GO:0070161 ion channel#PC00133;voltage-gated ion channel#PC00241 HUMAN|HGNC=33800|UniProtKB=Q6ZQX7 Q6ZQX7 LIAT1 PTHR36474:SF1 PROTEIN LIAT1 PROTEIN LIAT1 molecular condensate scaffold activity#GO:0140693;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 HUMAN|HGNC=3684|UniProtKB=P10767 P10767 FGF6 PTHR11486:SF25 FIBROBLAST GROWTH FACTOR FIBROBLAST GROWTH FACTOR 6 binding#GO:0005488;signaling receptor binding#GO:0005102;protein binding#GO:0005515;molecular function activator activity#GO:0140677;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;growth factor activity#GO:0008083;growth factor receptor binding#GO:0070851;fibroblast growth factor receptor binding#GO:0005104;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772 cellular response to fibroblast growth factor stimulus#GO:0044344;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;nervous system development#GO:0007399;cell surface receptor signaling pathway#GO:0007166;regulation of MAPK cascade#GO:0043408;multicellular organism development#GO:0007275;positive regulation of cell population proliferation#GO:0008284;response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cell differentiation#GO:0030154;cellular response to endogenous stimulus#GO:0071495;signaling#GO:0023052;animal gross anatomical part developmental process#GO:0160108;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;cellular response to growth factor stimulus#GO:0071363;positive regulation of cellular process#GO:0048522;multicellular organismal process#GO:0032501;fibroblast growth factor receptor signaling pathway#GO:0008543;positive regulation of response to stimulus#GO:0048584;regulation of locomotion#GO:0040012;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;response to fibroblast growth factor#GO:0071774;regulation of response to stimulus#GO:0048583;regulation of cell migration#GO:0030334;developmental process#GO:0032502;positive regulation of intracellular signal transduction#GO:1902533;cellular developmental process#GO:0048869;positive regulation of MAPK cascade#GO:0043410;neurogenesis#GO:0022008;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;response to growth factor#GO:0070848;regulation of cell communication#GO:0010646;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;cell communication#GO:0007154;regulation of cell motility#GO:2000145;regulation of cell population proliferation#GO:0042127;system development#GO:0048731 extracellular region#GO:0005576;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 growth factor#PC00112;intercellular signal molecule#PC00207 FGF signaling pathway#P00021>FGF#P00623 HUMAN|HGNC=991|UniProtKB=Q16548 Q16548 BCL2A1 PTHR11256:SF10 BCL-2 RELATED BCL-2-RELATED PROTEIN A1 channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 positive regulation of cellular process#GO:0048522;biological regulation#GO:0065007;negative regulation of apoptotic process#GO:0043066;DNA damage response#GO:0006974;negative regulation of cellular process#GO:0048523;apoptotic signaling pathway#GO:0097190;cell death#GO:0008219;cellular response to stimulus#GO:0051716;mitochondrial fusion#GO:0008053;programmed cell death#GO:0012501;regulation of cellular process#GO:0050794;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;positive regulation of biological process#GO:0048518;negative regulation of programmed cell death#GO:0043069;signal transduction#GO:0007165;cellular process#GO:0009987;organelle organization#GO:0006996;intrinsic apoptotic signaling pathway in response to DNA damage#GO:0008630;response to stress#GO:0006950;mitochondrion organization#GO:0007005;apoptotic mitochondrial changes#GO:0008637;organelle fusion#GO:0048284;regulation of apoptotic process#GO:0042981;cell surface receptor signaling pathway#GO:0007166;cellular component organization or biogenesis#GO:0071840;positive regulation of apoptotic process#GO:0043065;regulation of biological process#GO:0050789;apoptotic process#GO:0006915;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;signaling#GO:0023052;extrinsic apoptotic signaling pathway#GO:0097191;response to stimulus#GO:0050896;positive regulation of programmed cell death#GO:0043068;release of cytochrome c from mitochondria#GO:0001836;cellular response to stress#GO:0033554;intrinsic apoptotic signaling pathway#GO:0097193 membrane#GO:0016020;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;organelle outer membrane#GO:0031968;cytoplasm#GO:0005737;mitochondrial outer membrane#GO:0005741;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;organelle envelope#GO:0031967;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;outer membrane#GO:0019867;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 Apoptosis signaling pathway#P00006>A1#P00283 HUMAN|HGNC=24857|UniProtKB=Q9NRH1 Q9NRH1 YAE1 PTHR18829:SF0 PROTEIN YAE1 HOMOLOG PROTEIN YAE1 HOMOLOG HUMAN|HGNC=20371|UniProtKB=Q86Y39 Q86Y39 NDUFA11 PTHR21382:SF1 NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 11 membrane#GO:0016020;oxidoreductase complex#GO:1990204;membrane protein complex#GO:0098796;respiratory chain complex#GO:0098803;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;respiratory chain complex I#GO:0045271;catalytic complex#GO:1902494;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HUMAN|HGNC=15928|UniProtKB=O00241 O00241 SIRPB1 PTHR19971:SF32 SIGNAL-REGULATORY PROTEIN BETA SIGNAL-REGULATORY PROTEIN BETA-1 regulation of transport#GO:0051049;regulation of localization#GO:0032879;positive regulation of leukocyte activation#GO:0002696;regulation of endocytosis#GO:0030100;regulation of leukocyte cell-cell adhesion#GO:1903037;positive regulation of cell activation#GO:0050867;regulation of multicellular organismal process#GO:0051239;positive regulation of leukocyte cell-cell adhesion#GO:1903039;biological regulation#GO:0065007;regulation of cell adhesion#GO:0030155;regulation of T cell activation#GO:0050863;positive regulation of endocytosis#GO:0045807;positive regulation of T cell activation#GO:0050870;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of transport#GO:0051050;positive regulation of immune system process#GO:0002684;positive regulation of cell-cell adhesion#GO:0022409;positive regulation of lymphocyte activation#GO:0051251;positive regulation of cellular component organization#GO:0051130;regulation of lymphocyte activation#GO:0051249;regulation of cell-cell adhesion#GO:0022407;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of cellular component organization#GO:0051128;positive regulation of cell adhesion#GO:0045785;regulation of cell activation#GO:0050865;positive regulation of multicellular organismal process#GO:0051240;regulation of biological process#GO:0050789;regulation of leukocyte activation#GO:0002694 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=1744|UniProtKB=Q99741 Q99741 CDC6 PTHR10763:SF26 CELL DIVISION CONTROL PROTEIN 6-RELATED DNA REPLICATION FACTOR CDC6 DNA replication origin binding#GO:0003688;nucleic acid binding#GO:0003676;binding#GO:0005488;double-stranded DNA binding#GO:0003690;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;sequence-specific double-stranded DNA binding#GO:1990837 cellular process#GO:0009987;DNA replication#GO:0006260;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;nucleobase-containing compound metabolic process#GO:0006139;DNA replication initiation#GO:0006270;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;DNA-templated DNA replication#GO:0006261 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 replication origin binding protein#PC00199 HUMAN|HGNC=23465|UniProtKB=Q5VUJ5 Q5VUJ5 AGAP7P PTHR45819:SF7 CENTAURIN-GAMMA-1A ARF-GAP WITH GTPASE, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 4-RELATED hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924;enzyme regulator activity#GO:0030234;hydrolase activity#GO:0016787;molecular function activator activity#GO:0140677;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;enzyme activator activity#GO:0008047;hydrolase activity, acting on acid anhydrides#GO:0016817;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;ribonucleoside triphosphate phosphatase activity#GO:0017111;molecular function regulator activity#GO:0098772 G-protein modulator#PC00022;GTPase-activating protein#PC00257 HUMAN|HGNC=11077|UniProtKB=Q6AI14 Q6AI14 SLC9A4 PTHR10110:SF103 SODIUM/HYDROGEN EXCHANGER SODIUM_HYDROGEN EXCHANGER 4 metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;metal cation:proton antiporter activity#GO:0051139;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;secondary active transmembrane transporter activity#GO:0015291;antiporter activity#GO:0015297;proton transmembrane transporter activity#GO:0015078;monoatomic cation transmembrane transporter activity#GO:0008324;potassium ion transmembrane transporter activity#GO:0015079 intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;inorganic cation import across plasma membrane#GO:0098659;establishment of localization#GO:0051234;import into cell#GO:0098657;intracellular monoatomic cation homeostasis#GO:0030003;transport#GO:0006810;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;monoatomic cation transmembrane transport#GO:0098655;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;regulation of intracellular pH#GO:0051453;regulation of pH#GO:0006885;metal ion transport#GO:0030001;homeostatic process#GO:0042592;inorganic ion import across plasma membrane#GO:0099587;import across plasma membrane#GO:0098739;sodium ion transport#GO:0006814;intracellular monoatomic ion homeostasis#GO:0006873 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 secondary carrier transporter#PC00258 HUMAN|HGNC=24318|UniProtKB=Q9P298 Q9P298 HIGD1B PTHR12297:SF9 HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED HIG1 DOMAIN FAMILY MEMBER 1B protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;mitochondrial respiratory chain complex assembly#GO:0033108;mitochondrion organization#GO:0007005;cellular component assembly#GO:0022607;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739 scaffold/adaptor protein#PC00226 HUMAN|HGNC=15024|UniProtKB=Q96R54 Q96R54 OR14A2 PTHR26452:SF930 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 14A2 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 sensory perception of chemical stimulus#GO:0007606;nervous system process#GO:0050877;sensory perception#GO:0007600;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;system process#GO:0003008 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=33111|UniProtKB=Q8NCA9 Q8NCA9 ZNF784 PTHR24393:SF56 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 784 sequence-specific double-stranded DNA binding#GO:1990837;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulator activity#GO:0140110;DNA-binding transcription activator activity#GO:0001216;transcription regulatory region nucleic acid binding#GO:0001067 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=15814|UniProtKB=Q9NR19 Q9NR19 ACSS2 PTHR24095:SF126 ACETYL-COENZYME A SYNTHETASE ACETYL-COENZYME A SYNTHETASE, CYTOPLASMIC ligase activity, forming carbon-sulfur bonds#GO:0016877;catalytic activity#GO:0003824;ligase activity#GO:0016874 nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;acyl-CoA metabolic process#GO:0006637;nucleoside phosphate biosynthetic process#GO:1901293;cellular process#GO:0009987;sulfur compound metabolic process#GO:0006790;organophosphate metabolic process#GO:0019637;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;acetyl-CoA metabolic process#GO:0006084;purine-containing compound biosynthetic process#GO:0072522;organophosphate biosynthetic process#GO:0090407;purine-containing compound metabolic process#GO:0072521;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 ligase#PC00142 Acetate utilization#P02722>Acetyl-CoA synthetase#P02803 HUMAN|HGNC=26914|UniProtKB=Q8N0Z8 Q8N0Z8 PUSL1 PTHR11142:SF33 PSEUDOURIDYLATE SYNTHASE TRNA PSEUDOURIDINE SYNTHASE-LIKE 1 catalytic activity, acting on a tRNA#GO:0140101;isomerase activity#GO:0016853;catalytic activity, acting on RNA#GO:0140098;intramolecular transferase activity#GO:0016866;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;tRNA processing#GO:0008033;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187;tRNA modification#GO:0006400;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA modification#GO:0016556;pseudouridine synthesis#GO:0001522 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;intracellular organelle lumen#GO:0070013 lyase#PC00144 HUMAN|HGNC=1117|UniProtKB=Q9UPA5 Q9UPA5 BSN PTHR14113:SF1 PICCOLO/BASSOON PROTEIN BASSOON structural constituent of synapse#GO:0098918;structural molecule activity#GO:0005198 cellular component organization#GO:0016043;cell junction assembly#GO:0034329;cell junction organization#GO:0034330;synapse assembly#GO:0007416;animal gross anatomical part developmental process#GO:0160108;protein localization to cell junction#GO:1902414;synapse organization#GO:0050808;anatomical structure development#GO:0048856;localization#GO:0051179;system development#GO:0048731;cellular component biogenesis#GO:0044085;macromolecule localization#GO:0033036;cellular process#GO:0009987;multicellular organismal process#GO:0032501;cellular component assembly#GO:0022607;nervous system development#GO:0007399;developmental process#GO:0032502;protein localization to synapse#GO:0035418;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;intracellular protein localization#GO:0008104 membraneless organelle#GO:0043228;presynaptic active zone#GO:0048786;cell junction#GO:0030054;cytoskeleton#GO:0005856;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;glutamatergic synapse#GO:0098978;cell periphery#GO:0071944;presynapse#GO:0098793;neuron projection#GO:0043005;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;axon#GO:0030424;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;GABA-ergic synapse#GO:0098982;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;cell cortex#GO:0005938;cortical cytoskeleton#GO:0030863 HUMAN|HGNC=32008|UniProtKB=A0PK00 A0PK00 TMEM120B PTHR21433:SF2 TRANSMEMBRANE PROTEIN INDUCED BY TUMOR NECROSIS FACTOR ALPHA TRANSMEMBRANE PROTEIN 120B cellular developmental process#GO:0048869;cell differentiation#GO:0030154;fat cell differentiation#GO:0045444;cellular process#GO:0009987;developmental process#GO:0032502 intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;organelle inner membrane#GO:0019866;membrane#GO:0016020;organelle envelope#GO:0031967;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;nuclear membrane#GO:0031965;membrane-bounded organelle#GO:0043227;nuclear inner membrane#GO:0005637;intracellular organelle#GO:0043229 HUMAN|HGNC=16231|UniProtKB=Q9NTU7 Q9NTU7 CBLN4 PTHR22923:SF3 CEREBELLIN-RELATED CEREBELLIN-4 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 scaffold/adaptor protein#PC00226 HUMAN|HGNC=27375|UniProtKB=Q8IXL7 Q8IXL7 MSRB3 PTHR10173:SF56 METHIONINE SULFOXIDE REDUCTASE METHIONINE-R-SULFOXIDE REDUCTASE B3 catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;catalytic activity#GO:0003824 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 reductase#PC00198;metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HUMAN|Gene=LORF2_HUMAN|UniProtKB=O00370 O00370 PTHR25952:SF255 ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN LINE-1 RETROTRANSPOSABLE ELEMENT ORF2 PROTEIN HUMAN|HGNC=37170|UniProtKB=S4R3P1 S4R3P1 MTRNR2L13 PTHR33895:SF17 HUMANIN-LIKE 4 HUMANIN-LIKE 13 signaling receptor regulator activity#GO:0030545;molecular function inhibitor activity#GO:0140678;molecular function regulator activity#GO:0098772;signaling receptor inhibitor activity#GO:0030547 negative regulation of cellular process#GO:0048523;regulation of apoptotic process#GO:0042981;regulation of cellular process#GO:0050794;negative regulation of apoptotic process#GO:0043066;biological regulation#GO:0065007;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of programmed cell death#GO:0043069 HUMAN|HGNC=4422|UniProtKB=P15586 P15586 GNS PTHR43108:SF5 N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER N-ACETYLGLUCOSAMINE-6-SULFATASE hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;hydrolase activity#GO:0016787 primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;catabolic process#GO:0009056;carbohydrate derivative catabolic process#GO:1901136;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;glycoprotein metabolic process#GO:0009100;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;proteoglycan metabolic process#GO:0006029 lysosome#GO:0005764;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vacuole#GO:0005773;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;lytic vacuole#GO:0000323;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 hydrolase#PC00121 HUMAN|HGNC=17948|UniProtKB=Q9Y2T7 Q9Y2T7 YBX2 PTHR11544:SF61 COLD SHOCK DOMAIN CONTAINING PROTEINS Y-BOX-BINDING PROTEIN 2 binding#GO:0005488;nucleic acid binding#GO:0003676 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=12590|UniProtKB=P07919 P07919 UQCRH PTHR15336:SF3 UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 7.8 KDA PROTEIN CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL energy derivation by oxidation of organic compounds#GO:0015980;cellular respiration#GO:0045333;ATP synthesis coupled electron transport#GO:0042773;oxidative phosphorylation#GO:0006119;aerobic respiration#GO:0009060;aerobic electron transport chain#GO:0019646;metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091;electron transport chain#GO:0022900;respiratory electron transport chain#GO:0022904;cellular process#GO:0009987;mitochondrial ATP synthesis coupled electron transport#GO:0042775;mitochondrial electron transport, ubiquinol to cytochrome c#GO:0006122 catalytic complex#GO:1902494;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;respiratory chain complex III#GO:0045275;membrane protein complex#GO:0098796;membrane#GO:0016020;oxidoreductase complex#GO:1990204;respiratory chain complex#GO:0098803;cytochrome complex#GO:0070069;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 reductase#PC00198;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=626|UniProtKB=P07741 P07741 APRT PTHR32315:SF3 ADENINE PHOSPHORIBOSYLTRANSFERASE ADENINE PHOSPHORIBOSYLTRANSFERASE nucleotide binding#GO:0000166;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;cation binding#GO:0043169;pentosyltransferase activity#GO:0016763;small molecule binding#GO:0036094;anion binding#GO:0043168;ion binding#GO:0043167;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;ribonucleotide binding#GO:0032553;purine nucleotide binding#GO:0017076;transferase activity#GO:0016740;carbohydrate derivative binding#GO:0097367;binding#GO:0005488;nucleoside phosphate binding#GO:1901265 ribose phosphate biosynthetic process#GO:0046390;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing compound biosynthetic process#GO:0034654;purine nucleobase metabolic process#GO:0006144;carbohydrate derivative biosynthetic process#GO:1901137;purine nucleoside monophosphate metabolic process#GO:0009126;nucleobase-containing small molecule metabolic process#GO:0055086;phosphorus metabolic process#GO:0006793;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;small molecule metabolic process#GO:0044281;purine ribonucleoside monophosphate metabolic process#GO:0009167;nucleoside monophosphate biosynthetic process#GO:0009124;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;ribonucleotide metabolic process#GO:0009259;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide biosynthetic process#GO:0009165;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;carbohydrate derivative metabolic process#GO:1901135;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase metabolic process#GO:0009112;primary metabolic process#GO:0044238;nucleoside monophosphate metabolic process#GO:0009123;nucleoside phosphate metabolic process#GO:0006753;organophosphate biosynthetic process#GO:0090407 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 transferase#PC00220 Adenine and hypoxanthine salvage pathway#P02723>Adenine phosphoribosyl transferase#P02810 HUMAN|HGNC=16247|UniProtKB=Q5JXA9 Q5JXA9 SIRPB2 PTHR19971:SF9 SIGNAL-REGULATORY PROTEIN BETA SIGNAL-REGULATORY PROTEIN BETA-2 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=29086|UniProtKB=Q66GS9 Q66GS9 CEP135 PTHR23159:SF18 CENTROSOMAL PROTEIN 2 CENTROSOMAL PROTEIN OF 135 KDA cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;microtubule organizing center organization#GO:0031023;microtubule-based process#GO:0007017;centrosome duplication#GO:0051298;cell cycle#GO:0007049;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;centrosome cycle#GO:0007098;cell cycle process#GO:0022402;microtubule cytoskeleton organization#GO:0000226;organelle assembly#GO:0070925;centriole replication#GO:0007099 microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;centriole#GO:0005814;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;microtubule organizing center#GO:0005815;centrosome#GO:0005813;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=5099|UniProtKB=P49639 P49639 HOXA1 PTHR45946:SF3 HOMEOBOX PROTEIN ROUGH-RELATED HOMEOBOX PROTEIN HOX-A1 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119 HUMAN|HGNC=15378|UniProtKB=Q8NGE3 Q8NGE3 OR10P1 PTHR26453:SF194 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 10P1 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 response to stimulus#GO:0050896;response to chemical#GO:0042221;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;detection of chemical stimulus#GO:0009593;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;system process#GO:0003008;sensory perception#GO:0007600;nervous system process#GO:0050877;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=16087|UniProtKB=Q9BWM7 Q9BWM7 SFXN3 PTHR11153:SF20 SIDEROFLEXIN SIDEROFLEXIN-3 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 mitochondrial transmembrane transport#GO:1990542;localization#GO:0051179;amino acid transmembrane transport#GO:0003333;neutral amino acid transport#GO:0015804;transmembrane transport#GO:0055085;cellular localization#GO:0051641;mitochondrial transport#GO:0006839;carboxylic acid transmembrane transport#GO:1905039;intracellular transport#GO:0046907;transport#GO:0006810;carboxylic acid transport#GO:0046942;amino acid transport#GO:0006865;organic acid transport#GO:0015849;establishment of localization#GO:0051234;nitrogen compound transport#GO:0071705;establishment of localization in cell#GO:0051649;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;organelle envelope#GO:0031967;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 primary active transporter#PC00068 HUMAN|HGNC=5972|UniProtKB=Q99665 Q99665 IL12RB2 PTHR23036:SF79 CYTOKINE RECEPTOR INTERLEUKIN-12 RECEPTOR SUBUNIT BETA-2 protein binding#GO:0005515;molecular transducer activity#GO:0060089;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888;immune receptor activity#GO:0140375;signaling receptor activity#GO:0038023;cytokine binding#GO:0019955;cytokine receptor activity#GO:0004896;coreceptor activity#GO:0015026 cell surface receptor signaling pathway#GO:0007166;response to cytokine#GO:0034097;response to chemical#GO:0042221;biological regulation#GO:0065007;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;regulation of cell population proliferation#GO:0042127;cell communication#GO:0007154;response to peptide#GO:1901652;cytokine-mediated signaling pathway#GO:0019221;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;positive regulation of cell population proliferation#GO:0008284;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345 membrane#GO:0016020;cell periphery#GO:0071944;signaling receptor complex#GO:0043235;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 Interleukin signaling pathway#P00036>Receptor subunit beta#P00974 HUMAN|HGNC=493|UniProtKB=Q01484 Q01484 ANK2 PTHR24133:SF36 ANKYRIN DOMAIN-CONTAINING ANKYRIN-2 protein-containing complex binding#GO:0044877;protein binding#GO:0005515;transmembrane transporter binding#GO:0044325;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;cytoskeletal adaptor activity#GO:0008093;cytoskeletal protein binding#GO:0008092;molecular adaptor activity#GO:0060090 cellular process#GO:0009987;protein localization to plasma membrane#GO:0072659;macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657;intracellular protein localization#GO:0008104;cellular localization#GO:0051641;localization#GO:0051179;localization within membrane#GO:0051668;protein localization to cell periphery#GO:1990778 plasma membrane#GO:0005886;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165;neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HUMAN|HGNC=15988|UniProtKB=Q53F39 Q53F39 MPPE1 PTHR13315:SF0 METALLO PHOSPHOESTERASE RELATED METALLOPHOSPHOESTERASE 1 esterase#PC00097;hydrolase#PC00121;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=2673|UniProtKB=P51398 P51398 DAP3 PTHR12810:SF0 MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S29 SMALL RIBOSOMAL SUBUNIT PROTEIN MS29 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 membrane-bounded organelle#GO:0043227;mitochondrial ribosome#GO:0005761;organellar ribosome#GO:0000313;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;small ribosomal subunit#GO:0015935;mitochondrial matrix#GO:0005759;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;ribosome#GO:0005840;organelle lumen#GO:0043233;membraneless organelle#GO:0043228;mitochondrial small ribosomal subunit#GO:0005763;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;membrane-enclosed lumen#GO:0031974 ribosomal protein#PC00202;translational protein#PC00263 HUMAN|HGNC=26942|UniProtKB=Q9NZZ3 Q9NZZ3 CHMP5 PTHR22761:SF85 CHARGED MULTIVESICULAR BODY PROTEIN CHARGED MULTIVESICULAR BODY PROTEIN 5 localization#GO:0051179;cellular localization#GO:0051641;membrane assembly#GO:0071709;cellular component organization#GO:0016043;late endosome to vacuole transport#GO:0045324;vacuolar transport#GO:0007034;transport#GO:0006810;intracellular transport#GO:0046907;endosomal transport#GO:0016197;vesicle budding from membrane#GO:0006900;nuclear envelope organization#GO:0006998;vesicle organization#GO:0016050;cellular component organization or biogenesis#GO:0071840;nucleus organization#GO:0006997;establishment of localization#GO:0051234;establishment of localization in cell#GO:0051649;multivesicular body sorting pathway#GO:0071985;cellular process#GO:0009987;late endosome to vacuole transport via multivesicular body sorting pathway#GO:0032511;nuclear membrane organization#GO:0071763;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;cellular component assembly#GO:0022607;endosome transport via multivesicular body sorting pathway#GO:0032509;vesicle-mediated transport#GO:0016192 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;organelle envelope#GO:0031967;vesicle#GO:0031982;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;endosome membrane#GO:0010008;intracellular organelle#GO:0043229;late endosome#GO:0005770;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;nuclear envelope#GO:0005635;membrane#GO:0016020;vesicle membrane#GO:0012506;nucleus#GO:0005634;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588 membrane traffic protein#PC00150 HUMAN|HGNC=23357|UniProtKB=Q9ULC4 Q9ULC4 MCTS1 PTHR22798:SF10 MCT-1 PROTEIN MALIGNANT T-CELL-AMPLIFIED SEQUENCE 1 translation factor activity#GO:0180051;translation initiation factor activity#GO:0003743 translational initiation#GO:0006413;translation#GO:0006412;cytoplasmic translational initiation#GO:0002183;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;cytoplasmic translation#GO:0002181;gene expression#GO:0010467;protein biosynthetic process#GO:0160307 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 translation initiation factor#PC00224 HUMAN|HGNC=3228|UniProtKB=Q15768 Q15768 EFNB3 PTHR11304:SF34 EPHRIN EPHRIN-B3 protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488 animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;neuron development#GO:0048666;axonogenesis#GO:0007409;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cell morphogenesis#GO:0000902;response to stimulus#GO:0050896;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell development#GO:0048468;signaling#GO:0023052;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell surface receptor signaling pathway#GO:0007166;neuron differentiation#GO:0030182;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cell projection morphogenesis#GO:0048858;neuron projection development#GO:0031175;cellular process#GO:0009987;signal transduction#GO:0007165;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;cell communication#GO:0007154;system development#GO:0048731;ephrin receptor signaling pathway#GO:0048013;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;neuron projection guidance#GO:0097485;axon guidance#GO:0007411;axon development#GO:0061564;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007 cell junction#GO:0030054;synaptic membrane#GO:0097060;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;glutamatergic synapse#GO:0098978;synapse#GO:0045202;plasma membrane#GO:0005886;presynaptic membrane#GO:0042734;membrane#GO:0016020;presynapse#GO:0098793;cell periphery#GO:0071944 membrane-bound signaling molecule#PC00152;intercellular signal molecule#PC00207 HUMAN|HGNC=25596|UniProtKB=Q96AE7 Q96AE7 TTC17 PTHR16091:SF1 TTC17 PROTEIN TETRATRICOPEPTIDE REPEAT PROTEIN 17 protein-containing complex assembly#GO:0065003;protein polymerization#GO:0051258;cellular component organization#GO:0016043;actin filament polymerization#GO:0030041;cell projection organization#GO:0030030;actin cytoskeleton organization#GO:0030036;actin filament-based process#GO:0030029;supramolecular fiber organization#GO:0097435;cilium organization#GO:0044782;actin polymerization or depolymerization#GO:0008154;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;actin filament organization#GO:0007015;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;actin cytoskeleton#GO:0015629;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232 HUMAN|HGNC=15736|UniProtKB=Q8IV36 Q8IV36 HID1 PTHR21575:SF12 PROTEIN HID1 PROTEIN HID1 developmental process#GO:0032502;vesicle organization#GO:0016050;anatomical structure development#GO:0048856;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;Golgi organization#GO:0007030;anatomical structure maturation#GO:0071695;cellular component organization#GO:0016043;organelle organization#GO:0006996;endomembrane system organization#GO:0010256;developmental maturation#GO:0021700 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;Golgi cisterna#GO:0031985;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;cytosol#GO:0005829;Golgi stack#GO:0005795 HUMAN|HGNC=13403|UniProtKB=Q9BYU1 Q9BYU1 PBX4 PTHR11850:SF98 HOMEOBOX PROTEIN TRANSCRIPTION FACTORS PRE-B-CELL LEUKEMIA TRANSCRIPTION FACTOR 4 transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;DNA-binding transcription activator activity#GO:0001216;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;sequence-specific DNA binding#GO:0043565 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;brain development#GO:0007420;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;multicellular organismal process#GO:0032501;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;sensory organ development#GO:0007423;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;regulation of macromolecule metabolic process#GO:0060255;animal organ morphogenesis#GO:0009887;regulation of cellular process#GO:0050794;visual system development#GO:0150063;positive regulation of RNA metabolic process#GO:0051254;embryonic organ development#GO:0048568;positive regulation of biosynthetic process#GO:0009891;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;sensory system development#GO:0048880;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;embryo development#GO:0009790;nervous system development#GO:0007399;head development#GO:0060322;positive regulation of transcription by RNA polymerase II#GO:0045944;neuron differentiation#GO:0030182;multicellular organism development#GO:0007275;animal organ development#GO:0048513;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;central nervous system development#GO:0007417;cell development#GO:0048468;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;eye development#GO:0001654;neuron development#GO:0048666 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=16825|UniProtKB=Q96EF0 Q96EF0 MTMR8 PTHR10807:SF36 MYOTUBULARIN-RELATED PHOSPHATIDYLINOSITOL-3,5-BISPHOSPHATE 3-PHOSPHATASE MTMR8 phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791 organophosphate metabolic process#GO:0019637;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;phospholipid dephosphorylation#GO:0046839;cellular process#GO:0009987;phosphate-containing compound metabolic process#GO:0006796;glycerolipid metabolic process#GO:0046486;glycerophospholipid metabolic process#GO:0006650;phospholipid metabolic process#GO:0006644;metabolic process#GO:0008152;phosphatidylinositol dephosphorylation#GO:0046856;phosphatidylinositol metabolic process#GO:0046488;lipid metabolic process#GO:0006629;lipid modification#GO:0030258;dephosphorylation#GO:0016311 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle envelope#GO:0031967;membrane#GO:0016020;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 phosphatase#PC00181 HUMAN|HGNC=21731|UniProtKB=Q8N0Y7 Q8N0Y7 PGAM4 PTHR11931:SF14 PHOSPHOGLYCERATE MUTASE PHOSPHOGLYCERATE MUTASE 4-RELATED isomerase activity#GO:0016853;phosphoglycerate mutase activity#GO:0004619;catalytic activity#GO:0003824;intramolecular transferase activity#GO:0016866;intramolecular phosphotransferase activity#GO:0016868 purine nucleoside diphosphate metabolic process#GO:0009135;ribonucleotide metabolic process#GO:0009259;oxoacid metabolic process#GO:0043436;nucleotide metabolic process#GO:0009117;carbohydrate catabolic process#GO:0016052;carboxylic acid metabolic process#GO:0019752;phosphorus metabolic process#GO:0006793;monocarboxylic acid metabolic process#GO:0032787;purine-containing compound metabolic process#GO:0072521;ribonucleoside diphosphate metabolic process#GO:0009185;pyridine-containing compound catabolic process#GO:0072526;purine nucleotide metabolic process#GO:0006163;small molecule metabolic process#GO:0044281;small molecule catabolic process#GO:0044282;pyridine nucleotide catabolic process#GO:0019364;pyruvate metabolic process#GO:0006090;purine ribonucleotide metabolic process#GO:0009150;monosaccharide metabolic process#GO:0005996;metabolic process#GO:0008152;ADP catabolic process#GO:0046032;glucose metabolic process#GO:0006006;purine-containing compound catabolic process#GO:0072523;purine nucleoside diphosphate catabolic process#GO:0009137;nucleobase-containing small molecule metabolic process#GO:0055086;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;ATP metabolic process#GO:0046034;nicotinamide nucleotide metabolic process#GO:0046496;nucleoside diphosphate metabolic process#GO:0009132;purine nucleotide catabolic process#GO:0006195;pyridine-containing compound metabolic process#GO:0072524;cellular respiration#GO:0045333;organophosphate catabolic process#GO:0046434;ribonucleoside diphosphate catabolic process#GO:0009191;purine ribonucleoside diphosphate catabolic process#GO:0009181;aerobic respiration#GO:0009060;hexose metabolic process#GO:0019318;primary metabolic process#GO:0044238;purine nucleoside triphosphate metabolic process#GO:0009144;nucleoside diphosphate catabolic process#GO:0009134;purine ribonucleotide catabolic process#GO:0009154;nucleoside phosphate catabolic process#GO:1901292;catabolic process#GO:0009056;nucleoside phosphate metabolic process#GO:0006753;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate derivative catabolic process#GO:1901136;carbohydrate metabolic process#GO:0005975;nucleotide catabolic process#GO:0009166;purine ribonucleoside diphosphate metabolic process#GO:0009179;generation of precursor metabolites and energy#GO:0006091;energy derivation by oxidation of organic compounds#GO:0015980;ADP metabolic process#GO:0046031;nucleobase-containing compound catabolic process#GO:0034655;organophosphate metabolic process#GO:0019637;glycolytic process#GO:0006096;purine ribonucleoside triphosphate metabolic process#GO:0009205;ribonucleotide catabolic process#GO:0009261;carbohydrate derivative metabolic process#GO:1901135;nucleobase-containing compound metabolic process#GO:0006139 cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;sperm flagellum#GO:0036126;cellular anatomical structure#GO:0110165;motile cilium#GO:0031514;organelle#GO:0043226;sperm principal piece#GO:0097228;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cilium#GO:0005929;9+2 motile cilium#GO:0097729 mutase#PC00160;isomerase#PC00135 Glycolysis#P00024>Phosphoglyceromutase#P00680 HUMAN|HGNC=16639|UniProtKB=Q9UQ35 Q9UQ35 SRRM2 PTHR34755:SF3 SERINE/ARGININE REPETITIVE MATRIX PROTEIN 3-RELATED SERINE_ARGININE REPETITIVE MATRIX PROTEIN 2 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729 HUMAN|HGNC=25400|UniProtKB=Q9HD64 Q9HD64 XAGE1A PTHR14047:SF31 P ANTIGEN FAMILY MEMBER 5-RELATED X ANTIGEN FAMILY MEMBER 1 HUMAN|HGNC=42956|UniProtKB=E9PQ53 E9PQ53 NDUFC2-KCTD14 PTHR13099:SF0 NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B14.5B NADH DEHYDROGENASE [UBIQUINONE] 1 SUBUNIT C2-RELATED respiratory chain complex I#GO:0045271;catalytic complex#GO:1902494;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;oxidoreductase complex#GO:1990204;membrane#GO:0016020;membrane protein complex#GO:0098796;respiratory chain complex#GO:0098803;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HUMAN|HGNC=29397|UniProtKB=Q14DG7 Q14DG7 TMEM132B PTHR13388:SF12 DETONATOR, ISOFORM E TRANSMEMBRANE PROTEIN 132B cellular anatomical structure#GO:0110165;membrane#GO:0016020 HUMAN|HGNC=26198|UniProtKB=Q8WWC4 Q8WWC4 MAIP1 PTHR13333:SF5 M-AAA PROTEASE-INTERACTING PROTEIN 1, MITOCHONDRIAL M-AAA PROTEASE-INTERACTING PROTEIN 1, MITOCHONDRIAL macromolecule localization#GO:0033036;organelle organization#GO:0006996;establishment of protein localization to membrane#GO:0090150;establishment of localization in cell#GO:0051649;mitochondrial membrane organization#GO:0007006;establishment of protein localization#GO:0045184;inner mitochondrial membrane organization#GO:0007007;cellular process#GO:0009987;protein insertion into membrane#GO:0051205;mitochondrion organization#GO:0007005;membrane organization#GO:0061024;cellular component organization or biogenesis#GO:0071840;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;cellular component organization#GO:0016043;protein localization to mitochondrion#GO:0070585;protein localization to organelle#GO:0033365;localization within membrane#GO:0051668;localization#GO:0051179;cellular localization#GO:0051641 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739 HUMAN|HGNC=5898|UniProtKB=A0A075B6K2 A0A075B6K2 IGLV3-12 PTHR23267:SF393 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN LAMBDA VARIABLE 3-12 response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=29350|UniProtKB=Q9H0B3 Q9H0B3 IQCN PTHR22590:SF2 MYOSIN MOTOR DOMAIN-CONTAINING PROTEIN IQ DOMAIN-CONTAINING PROTEIN N HUMAN|HGNC=21370|UniProtKB=Q6DKI1 Q6DKI1 RPL7L1 PTHR11524:SF13 60S RIBOSOMAL PROTEIN L7 RIBOSOMAL PROTEIN UL30-LIKE nucleic acid binding#GO:0003676;binding#GO:0005488;structural constituent of ribosome#GO:0003735;RNA binding#GO:0003723;structural molecule activity#GO:0005198 maturation of LSU-rRNA#GO:0000470;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;ribosome biogenesis#GO:0042254;ribosomal large subunit biogenesis#GO:0042273;nucleic acid biosynthetic process#GO:0141187 ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;cytosolic large ribosomal subunit#GO:0022625;cytosolic ribosome#GO:0022626;ribosome#GO:0005840;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737 ribosomal protein#PC00202 HUMAN|HGNC=30602|UniProtKB=H0Y354 H0Y354 FAM72C PTHR31841:SF1 PROTEIN FAM72A-RELATED PROTEIN FAM72A-RELATED cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=5115|UniProtKB=P17483 P17483 HOXB4 PTHR45771:SF3 HOMEOTIC PROTEIN DEFORMED HOMEOBOX PROTEIN HOX-B4 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of macromolecule biosynthetic process#GO:0010556;skeletal system morphogenesis#GO:0048705;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;regionalization#GO:0003002;multicellular organismal process#GO:0032501;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;animal organ morphogenesis#GO:0009887;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;embryo development ending in birth or egg hatching#GO:0009792;embryonic organ development#GO:0048568;pattern specification process#GO:0007389;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604;embryo development#GO:0009790;anterior/posterior pattern specification#GO:0009952;positive regulation of transcription by RNA polymerase II#GO:0045944;animal organ development#GO:0048513;multicellular organism development#GO:0007275;embryonic morphogenesis#GO:0048598;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;animal gross anatomical part developmental process#GO:0160108;chordate embryonic development#GO:0043009;skeletal system development#GO:0001501;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893 nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116;DNA-binding transcription factor#PC00218 HUMAN|HGNC=30664|UniProtKB=Q9H078 Q9H078 CLPB PTHR11638:SF93 ATP-DEPENDENT CLP PROTEASE MITOCHONDRIAL DISAGGREGASE catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP-dependent activity#GO:0140657;hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887 cellular response to heat#GO:0034605;response to heat#GO:0009408;response to stress#GO:0006950;response to abiotic stimulus#GO:0009628;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;response to temperature stimulus#GO:0009266;cellular response to stress#GO:0033554 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 protease#PC00190;protein modifying enzyme#PC00260 HUMAN|HGNC=26067|UniProtKB=Q5TAA0 Q5TAA0 TTC22 PTHR16253:SF0 TETRATRICOPEPTIDE REPEAT PROTEIN 22 TETRATRICOPEPTIDE REPEAT PROTEIN 22 HUMAN|HGNC=16865|UniProtKB=Q92561 Q92561 PHYHIP PTHR15698:SF9 PROTEIN CBG15099 PHYTANOYL-COA HYDROXYLASE-INTERACTING PROTEIN cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=28956|UniProtKB=Q8N335 Q8N335 GPD1L PTHR11728:SF7 GLYCEROL-3-PHOSPHATE DEHYDROGENASE GLYCEROL-3-PHOSPHATE DEHYDROGENASE 1-LIKE PROTEIN catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614 carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;metabolic process#GO:0008152;phosphorus metabolic process#GO:0006793 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 oxidoreductase#PC00176;dehydrogenase#PC00092 HUMAN|HGNC=13300|UniProtKB=Q9BZJ8 Q9BZJ8 GPR61 PTHR22752:SF5 G PROTEIN-COUPLED RECEPTOR G PROTEIN-COUPLED RECEPTOR 61 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;cell communication#GO:0007154 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768;plasma membrane#GO:0005886;cytoplasm#GO:0005737;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020;signaling receptor complex#GO:0043235 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=26146|UniProtKB=Q9NQC8 Q9NQC8 IFT46 PTHR13376:SF0 INTRAFLAGELLAR TRANSPORT PROTEIN 46 HOMOLOG INTRAFLAGELLAR TRANSPORT PROTEIN 46 HOMOLOG organelle assembly#GO:0070925;microtubule-based transport#GO:0099111;localization#GO:0051179;cellular localization#GO:0051641;cilium organization#GO:0044782;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cell projection organization#GO:0030030;microtubule-based movement#GO:0007018;intraciliary transport#GO:0042073;plasma membrane bounded cell projection assembly#GO:0120031;intracellular transport#GO:0046907;transport#GO:0006810;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;microtubule-based process#GO:0007017;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;establishment of localization in cell#GO:0051649;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component assembly#GO:0022607;cytoskeleton-dependent intracellular transport#GO:0030705;plasma membrane bounded cell projection organization#GO:0120036 intraciliary transport particle#GO:0030990;intracellular organelle#GO:0043229;cilium#GO:0005929;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;motile cilium#GO:0031514;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;intraciliary transport particle B#GO:0030992;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232 HUMAN|HGNC=9964|UniProtKB=Q92785 Q92785 DPF2 PTHR45888:SF7 HL01030P-RELATED ZINC FINGER PROTEIN UBI-D4 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of developmental process#GO:0050793;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of cell differentiation#GO:0045595;negative regulation of cellular process#GO:0048523 chromatin#GO:0000785;nucleus#GO:0005634;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;SWI/SNF superfamily-type complex#GO:0070603;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;ATPase complex#GO:1904949;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=27607|UniProtKB=O75864 O75864 PPP1R37 PTHR24112:SF68 LEUCINE-RICH REPEAT, ISOFORM F-RELATED PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 37 regulation of actin nucleation#GO:0051125;regulation of actin filament-based process#GO:0032970;biological regulation#GO:0065007;regulation of actin cytoskeleton organization#GO:0032956;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794;cell migration#GO:0016477;cell motility#GO:0048870;regulation of supramolecular fiber organization#GO:1902903;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;regulation of actin filament organization#GO:0110053;cellular process#GO:0009987 plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;lamellipodium#GO:0030027;cell periphery#GO:0071944;membrane#GO:0016020;cell leading edge#GO:0031252 protein-binding activity modulator#PC00095 HUMAN|HGNC=15290|UniProtKB=Q6IEU7 Q6IEU7 OR5M10 PTHR48018:SF85 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5M10 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 sensory perception#GO:0007600;nervous system process#GO:0050877;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;signaling#GO:0023052;response to stimulus#GO:0050896;sensory perception of smell#GO:0007608;regulation of cellular process#GO:0050794;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;multicellular organismal process#GO:0032501 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=2079|UniProtKB=Q9UBY8 Q9UBY8 CLN8 PTHR13439:SF7 CT120 PROTEIN PROTEIN CLN8 binding#GO:0005488;lipid binding#GO:0008289 organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;metabolic process#GO:0008152;chemical homeostasis#GO:0048878;lipid metabolic process#GO:0006629;developmental process#GO:0032502;multicellular organism development#GO:0007275;primary metabolic process#GO:0044238;lipid homeostasis#GO:0055088;phosphorus metabolic process#GO:0006793;phospholipid metabolic process#GO:0006644;homeostatic process#GO:0042592;animal gross anatomical part developmental process#GO:0160108;anatomical structure development#GO:0048856;system development#GO:0048731 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;transferase#PC00220 HUMAN|HGNC=53895|UniProtKB=A0A075B734 A0A075B734 AQP7B PTHR43829:SF12 AQUAPORIN OR AQUAGLYCEROPORIN RELATED AQUAPORIN-7B-RELATED channel activity#GO:0015267;carbohydrate transmembrane transporter activity#GO:0015144;passive transmembrane transporter activity#GO:0022803;water transmembrane transporter activity#GO:0005372;water channel activity#GO:0015250;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 localization#GO:0051179;water transport#GO:0006833;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;organic hydroxy compound transport#GO:0015850;fluid transport#GO:0042044;carbohydrate transport#GO:0008643;transport#GO:0006810;carbohydrate transmembrane transport#GO:0034219;cellular process#GO:0009987 basal plasma membrane#GO:0009925;cell periphery#GO:0071944;basal part of cell#GO:0045178;basolateral plasma membrane#GO:0016323;membrane#GO:0016020;plasma membrane#GO:0005886;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165 transporter#PC00227 HUMAN|HGNC=5014|UniProtKB=P30519 P30519 HMOX2 PTHR10720:SF2 HEME OXYGENASE HEME OXYGENASE 2 monooxygenase activity#GO:0004497;catalytic activity#GO:0003824;heme binding#GO:0020037;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen#GO:0016712;oxidoreductase activity#GO:0016491;binding#GO:0005488;tetrapyrrole binding#GO:0046906 response to stimulus#GO:0050896;catabolic process#GO:0009056;heme metabolic process#GO:0042168;pigment metabolic process#GO:0042440;response to stress#GO:0006950;cellular process#GO:0009987;response to oxidative stress#GO:0006979;metabolic process#GO:0008152;tetrapyrrole metabolic process#GO:0033013;porphyrin-containing compound metabolic process#GO:0006778 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 oxidoreductase#PC00176;oxygenase#PC00177 HUMAN|HGNC=7685|UniProtKB=O43678 O43678 NDUFA2 PTHR12878:SF6 NADH-UBIQUINONE OXIDOREDUCTASE B8 SUBUNIT NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 2 respiratory chain complex I#GO:0045271;catalytic complex#GO:1902494;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;membrane#GO:0016020;oxidoreductase complex#GO:1990204;membrane protein complex#GO:0098796;respiratory chain complex#GO:0098803;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=4220|UniProtKB=P43026 P43026 GDF5 PTHR11848:SF44 TGF-BETA FAMILY GROWTH_DIFFERENTIATION FACTOR 5 signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;cytokine activity#GO:0005125 regulation of developmental process#GO:0050793;signaling#GO:0023052;response to stimulus#GO:0050896;response to growth factor#GO:0070848;cellular response to endogenous stimulus#GO:0071495;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;BMP signaling pathway#GO:0030509;regulation of multicellular organismal development#GO:2000026;positive regulation of multicellular organismal process#GO:0051240;cellular response to stimulus#GO:0051716;response to endogenous stimulus#GO:0009719;cellular response to growth factor stimulus#GO:0071363;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;biological regulation#GO:0065007;regulation of multicellular organismal process#GO:0051239;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;signal transduction#GO:0007165;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of developmental process#GO:0051094;cellular response to BMP stimulus#GO:0071773;response to BMP#GO:0071772;cell surface receptor signaling pathway#GO:0007166;regulation of cell differentiation#GO:0045595;positive regulation of cell differentiation#GO:0045597;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 growth factor#PC00112 TGF-beta signaling pathway#P00052>TGFbeta#P01286 HUMAN|HGNC=25075|UniProtKB=Q8TDW0 Q8TDW0 LRRC8C PTHR45752:SF24 LEUCINE-RICH REPEAT-CONTAINING VOLUME-REGULATED ANION CHANNEL SUBUNIT LRRC8C monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;passive transmembrane transporter activity#GO:0022803;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic anion transmembrane transporter activity#GO:0008509;monoatomic anion channel activity#GO:0005253;channel activity#GO:0015267 transport#GO:0006810;C4-dicarboxylate transport#GO:0015740;establishment of localization#GO:0051234;nitrogen compound transport#GO:0071705;aspartate transmembrane transport#GO:0015810;monoatomic ion transmembrane transport#GO:0034220;dicarboxylic acid transport#GO:0006835;biological regulation#GO:0065007;amino acid transmembrane transport#GO:0003333;cell communication#GO:0007154;localization#GO:0051179;intracellular signal transduction#GO:0035556;monoatomic anion transport#GO:0006820;cellular response to stimulus#GO:0051716;carbohydrate derivative transport#GO:1901264;regulation of cellular process#GO:0050794;organophosphate ester transport#GO:0015748;nucleobase-containing compound transport#GO:0015931;carboxylic acid transmembrane transport#GO:1905039;carboxylic acid transport#GO:0046942;amino acid transport#GO:0006865;organic acid transport#GO:0015849;acidic amino acid transport#GO:0015800;import into cell#GO:0098657;cellular process#GO:0009987;signal transduction#GO:0007165;monoatomic anion transmembrane transport#GO:0098656;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;import across plasma membrane#GO:0098739;signaling#GO:0023052 membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;plasma membrane#GO:0005886;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HUMAN|HGNC=5468|UniProtKB=P35858 P35858 IGFALS PTHR24373:SF285 SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=26892|UniProtKB=Q8NCL9 Q8NCL9 APCDD1L PTHR31021:SF3 ADENOMATOSIS POLYPOSIS COLI DOWN-REGULATED 1 PROTEIN APCDD1-LIKE HUMAN|HGNC=2417|UniProtKB=P22914 P22914 CRYGS PTHR11818:SF6 BETA/GAMMA CRYSTALLIN GAMMA-CRYSTALLIN S structural molecule activity#GO:0005198 multicellular organismal process#GO:0032501;sensory system development#GO:0048880;system process#GO:0003008;animal organ development#GO:0048513;multicellular organism development#GO:0007275;lens development in camera-type eye#GO:0002088;developmental process#GO:0032502;sensory organ development#GO:0007423;visual system development#GO:0150063;visual perception#GO:0007601;sensory perception of light stimulus#GO:0050953;eye development#GO:0001654;system development#GO:0048731;anatomical structure development#GO:0048856;nervous system process#GO:0050877;sensory perception#GO:0007600;animal gross anatomical part developmental process#GO:0160108;camera-type eye development#GO:0043010 structural protein#PC00211 HUMAN|HGNC=7097|UniProtKB=P14174 P14174 MIF PTHR11954:SF49 D-DOPACHROME DECARBOXYLASE MACROPHAGE MIGRATION INHIBITORY FACTOR signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;isomerase activity#GO:0016853;intramolecular oxidoreductase activity#GO:0016860;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;catalytic activity#GO:0003824;molecular function activator activity#GO:0140677;cytokine activity#GO:0005125 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 decarboxylase#PC00089;lyase#PC00144;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=29349|UniProtKB=Q9C0I3 Q9C0I3 CCSER1 PTHR22461:SF1 SERINE-RICH COILED-COIL DOMAIN-CONTAINING PROTEIN 2-RELATED SERINE-RICH COILED-COIL DOMAIN-CONTAINING PROTEIN 1 HUMAN|HGNC=16466|UniProtKB=Q9UMX1 Q9UMX1 SUFU PTHR10928:SF2 SUPPRESSOR OF FUSED SUPPRESSOR OF FUSED HOMOLOG molecular sequestering activity#GO:0140313;protein sequestering activity#GO:0140311 negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of signal transduction#GO:0009968;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;negative regulation of response to stimulus#GO:0048585;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of DNA-templated transcription#GO:0006355 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 scaffold/adaptor protein#PC00226 Hedgehog signaling pathway#P00025>Su(fu)#P00699 HUMAN|HGNC=14096|UniProtKB=O75467 O75467 ZNF324 PTHR24377:SF621 IP01015P-RELATED ZINC FINGER PROTEIN 324A-RELATED sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=23800|UniProtKB=Q9P2F8 Q9P2F8 SIPA1L2 PTHR15711:SF7 RAP GTPASE-ACTIVATING PROTEIN SIGNAL-INDUCED PROLIFERATION-ASSOCIATED 1-LIKE PROTEIN 2 nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047 glutamatergic synapse#GO:0098978;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell junction#GO:0030054 GTPase-activating protein#PC00257;G-protein modulator#PC00022 HUMAN|HGNC=13222|UniProtKB=Q9C0K0 Q9C0K0 BCL11B PTHR45993:SF4 B-CELL LYMPHOMA/LEUKEMIA 11 B-CELL LYMPHOMA_LEUKEMIA 11B sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244;DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=1305|UniProtKB=Q9NYP8 Q9NYP8 EPCIP PTHR35658:SF1 RCG58666, ISOFORM CRA_A EXOSOMAL POLYCYSTIN-1-INTERACTING PROTEIN transport#GO:0006810;organelle localization#GO:0051640;mitochondrion localization#GO:0051646;establishment of localization#GO:0051234;localization#GO:0051179;cellular process#GO:0009987;export from cell#GO:0140352;establishment of organelle localization#GO:0051656 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229 HUMAN|HGNC=33849|UniProtKB=Q6UXF7 Q6UXF7 CLEC18B PTHR10334:SF521 CYSTEINE-RICH SECRETORY PROTEIN-RELATED C-TYPE LECTIN DOMAIN FAMILY 18 MEMBER A-RELATED polysaccharide binding#GO:0030247;binding#GO:0005488;carbohydrate binding#GO:0030246 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090 HUMAN|HGNC=17846|UniProtKB=Q9H4F1 Q9H4F1 ST6GALNAC4 PTHR45906:SF4 ALPHA-N-ACETYL-NEURAMINYL-2,3-BETA-GALACTOSYL-1, 3-N-ACETYL-GALACTOSAMINIDE ALPHA-2,6-SIALYLTRANSFERASE-LIKE ALPHA-N-ACETYL-NEURAMINYL-2,3-BETA-GALACTOSYL-1,3-N-ACETYL-GALACTOSAMINIDE ALPHA-2,6-SIALYLTRANSFERASE glycosyltransferase activity#GO:0016757;sialyltransferase activity#GO:0008373;transferase activity#GO:0016740;catalytic activity#GO:0003824 lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;carbohydrate derivative biosynthetic process#GO:1901137;oligosaccharide metabolic process#GO:0009311;sphingolipid biosynthetic process#GO:0030148;metabolic process#GO:0008152;sphingolipid metabolic process#GO:0006665;lipid metabolic process#GO:0006629;ceramide biosynthetic process#GO:0046513;glycolipid metabolic process#GO:0006664;liposaccharide metabolic process#GO:1903509;carbohydrate metabolic process#GO:0005975;primary metabolic process#GO:0044238;ceramide metabolic process#GO:0006672;glycolipid biosynthetic process#GO:0009247;glycosphingolipid biosynthetic process#GO:0006688 HUMAN|Ensembl=ENSG00000273554.4|UniProtKB=A0AAG2SWV4 A0AAG2SWV4 PTHR11616:SF335 SODIUM/CHLORIDE DEPENDENT TRANSPORTER TRANSPORTER amino acid transmembrane transporter activity#GO:0015171;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;monoatomic anion transmembrane transporter activity#GO:0008509;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;symporter activity#GO:0015293;monoatomic cation transmembrane transporter activity#GO:0008324;chloride transmembrane transporter activity#GO:0015108;transmembrane transporter activity#GO:0022857;solute:monoatomic cation symporter activity#GO:0015294;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;carboxylic acid transmembrane transporter activity#GO:0046943;solute:sodium symporter activity#GO:0015370;amino acid:sodium symporter activity#GO:0005283 amino acid transport#GO:0006865;transport#GO:0006810;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;localization#GO:0051179;cellular process#GO:0009987;sodium ion transport#GO:0006814;sodium ion transmembrane transport#GO:0035725;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 primary active transporter#PC00068 HUMAN|HGNC=2749|UniProtKB=Q14562 Q14562 DHX8 PTHR18934:SF277 ATP-DEPENDENT RNA HELICASE ATP-DEPENDENT RNA HELICASE DHX8 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;ATP-dependent activity#GO:0140657;helicase activity#GO:0004386;isomerase activity#GO:0016853;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;RNA helicase activity#GO:0003724;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543 RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774 spliceosomal complex#GO:0005681;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;ribonucleoprotein complex#GO:1990904;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;catalytic step 2 spliceosome#GO:0071013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 RNA helicase#PC00032;RNA metabolism protein#PC00031 HUMAN|HGNC=25607|UniProtKB=Q9NV29 Q9NV29 TMEM100 PTHR16100:SF5 PHOSPHOINOSITIDE-INTERACTING PROTEIN FAMILY MEMBER TRANSMEMBRANE PROTEIN 100 cellular response to stimulus#GO:0051716;BMP signaling pathway#GO:0030509;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to growth factor#GO:0070848;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;cellular response to growth factor stimulus#GO:0071363;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;cell surface receptor signaling pathway#GO:0007166;response to BMP#GO:0071772;cellular response to BMP stimulus#GO:0071773;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;regulation of system process#GO:0044057 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HUMAN|HGNC=55197|UniProtKB=A0A494C071 A0A494C071 PWWP4 PTHR31333:SF2 PWWP DOMAIN-CONTAINING DNA REPAIR FACTOR 3 FAMILY MEMBER PWWP DOMAIN-CONTAINING DNA REPAIR FACTOR 4-RELATED DNA metabolism protein#PC00009 HUMAN|HGNC=1768|UniProtKB=Q9ULB4 Q9ULB4 CDH9 PTHR24027:SF99 CADHERIN-23 CADHERIN-9 binding#GO:0005488;cell adhesion molecule binding#GO:0050839;protein binding#GO:0005515;beta-catenin binding#GO:0008013 synaptic membrane adhesion#GO:0099560;anatomical structure development#GO:0048856;synapse organization#GO:0050808;cell adhesion#GO:0007155;cell morphogenesis#GO:0000902;cell motility#GO:0048870;cell junction organization#GO:0034330;anatomical structure morphogenesis#GO:0009653;cell junction assembly#GO:0034329;adherens junction organization#GO:0034332;cellular component organization#GO:0016043;cellular component organization or biogenesis#GO:0071840;cell-cell junction organization#GO:0045216;developmental process#GO:0032502;cell-cell junction assembly#GO:0007043;cellular component assembly#GO:0022607;cell migration#GO:0016477;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;cell-cell adhesion#GO:0098609 adherens junction#GO:0005912;anchoring junction#GO:0070161;cell junction#GO:0030054;extrinsic component of membrane#GO:0019898;extrinsic component of plasma membrane#GO:0019897;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane protein complex#GO:0098796;membrane#GO:0016020;cell-cell junction#GO:0005911 cell adhesion molecule#PC00069;cadherin#PC00057 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HUMAN|HGNC=7198|UniProtKB=Q86VD1 Q86VD1 MORC1 PTHR23337:SF6 ZINC FINGER CW-TYPE COILED-COIL DOMAIN PROTEIN 1 MORC FAMILY CW-TYPE ZINC FINGER PROTEIN 1 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=14648|UniProtKB=Q2VYF4 Q2VYF4 LETM2 PTHR14009:SF7 LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN LETM1 DOMAIN-CONTAINING PROTEIN LETM2, MITOCHONDRIAL transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 calcium ion transmembrane transport#GO:0070588;cellular component organization#GO:0016043;metal ion transport#GO:0030001;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;organelle organization#GO:0006996;mitochondrial calcium ion transmembrane transport#GO:0006851;cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;mitochondrion organization#GO:0007005;monoatomic ion transmembrane transport#GO:0034220;transport#GO:0006810;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;calcium ion transport#GO:0006816 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258;transporter#PC00227 HUMAN|HGNC=16412|UniProtKB=Q9NPP4 Q9NPP4 NLRC4 PTHR47688:SF1 NLR FAMILY CARD DOMAIN-CONTAINING PROTEIN 4 NLR FAMILY CARD DOMAIN-CONTAINING PROTEIN 4 HUMAN|HGNC=19835|UniProtKB=Q7Z553 Q7Z553 MDGA2 PTHR23282:SF137 APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR. MAM DOMAIN-CONTAINING GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR PROTEIN 2 HUMAN|HGNC=21289|UniProtKB=Q8IWV8 Q8IWV8 UBR2 PTHR21497:SF28 UBIQUITIN LIGASE E3 ALPHA-RELATED E3 UBIQUITIN-PROTEIN LIGASE UBR2 ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;cellular process#GO:0009987;protein ubiquitination#GO:0016567;proteasomal protein catabolic process#GO:0010498;post-translational protein modification#GO:0043687;protein modification by small protein conjugation or removal#GO:0070647;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;protein modification process#GO:0036211;primary metabolic process#GO:0044238;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056 ubiquitin ligase complex#GO:0000151;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;catalytic complex#GO:1902494;transferase complex#GO:1990234;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=18463|UniProtKB=Q8IZA3 Q8IZA3 H1-8 PTHR11467:SF42 HISTONE H1 HISTONE H1.8 nucleosome binding#GO:0031491;double-stranded DNA binding#GO:0003690;protein-containing complex binding#GO:0044877;DNA binding#GO:0003677;chromatin binding#GO:0003682;binding#GO:0005488;nucleic acid binding#GO:0003676;chromatin DNA binding#GO:0031490 negative regulation of metabolic process#GO:0009892;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of DNA metabolic process#GO:0051052;negative regulation of biological process#GO:0048519;negative regulation of DNA recombination#GO:0045910;cellular component organization#GO:0016043;chromosome condensation#GO:0030261;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of DNA recombination#GO:0000018;biological regulation#GO:0065007;negative regulation of DNA metabolic process#GO:0051053;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;organelle organization#GO:0006996;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;chromosome organization#GO:0051276;cellular component organization or biogenesis#GO:0071840;negative regulation of cellular process#GO:0048523 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=217|UniProtKB=Q9UHI8 Q9UHI8 ADAMTS1 PTHR13723:SF40 ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 1 metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 cellular component organization#GO:0016043;primary metabolic process#GO:0044238;cellular process#GO:0009987;protein metabolic process#GO:0019538;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;external encapsulating structure organization#GO:0045229;extracellular structure organization#GO:0043062;metabolic process#GO:0008152;proteolysis#GO:0006508 extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 HUMAN|HGNC=3516|UniProtKB=Q9UBQ6 Q9UBQ6 EXTL2 PTHR47844:SF1 SYNTHASE CPS1, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G02500)-RELATED EXOSTOSIN-LIKE 2 HUMAN|HGNC=12340|UniProtKB=Q9UHF7 Q9UHF7 TRPS1 PTHR47034:SF1 ZINC FINGER TRANSCRIPTION FACTOR TRPS1 ZINC FINGER TRANSCRIPTION FACTOR TRPS1 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 DNA-binding transcription factor#PC00218 HUMAN|HGNC=4586|UniProtKB=Q13224 Q13224 GRIN2B PTHR18966:SF382 IONOTROPIC GLUTAMATE RECEPTOR GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B voltage-gated channel activity#GO:0022832;voltage-gated monoatomic ion channel activity#GO:0005244;transmembrane signaling receptor activity#GO:0004888;gated channel activity#GO:0022836;monoatomic ion channel activity#GO:0005216;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion transmembrane transporter activity#GO:0015075;signaling receptor activity#GO:0038023;neurotransmitter receptor activity#GO:0030594;amino acid transmembrane transporter activity#GO:0015171;transporter activity#GO:0005215;molecular transducer activity#GO:0060089;channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276;carboxylic acid transmembrane transporter activity#GO:0046943;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;dicarboxylic acid transmembrane transporter activity#GO:0005310;glutamate receptor activity#GO:0008066;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;transmembrane transporter activity#GO:0022857 multicellular organismal process#GO:0032501;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;positive regulation of cellular process#GO:0048522;system process#GO:0003008;regulation of synaptic plasticity#GO:0048167;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;anterograde trans-synaptic signaling#GO:0098916;chemical synaptic transmission, postsynaptic#GO:0099565;regulation of cell communication#GO:0010646;modulation of chemical synaptic transmission#GO:0050804;chemical synaptic transmission#GO:0007268;cellular response to stimulus#GO:0051716;regulation of postsynaptic membrane potential#GO:0060078;cell communication#GO:0007154;trans-synaptic signaling#GO:0099537;regulation of trans-synaptic signaling#GO:0099177;synaptic transmission, glutamatergic#GO:0035249;synaptic signaling#GO:0099536;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;regulation of membrane potential#GO:0042391;cell surface receptor signaling pathway#GO:0007166;response to stimulus#GO:0050896;signaling#GO:0023052;regulation of biological process#GO:0050789;positive regulation of signaling#GO:0023056;regulation of biological quality#GO:0065008;positive regulation of synaptic transmission#GO:0050806;nervous system process#GO:0050877;regulation of signaling#GO:0023051 synaptic membrane#GO:0097060;signaling receptor complex#GO:0043235;transporter complex#GO:1990351;cell junction#GO:0030054;membrane#GO:0016020;cell periphery#GO:0071944;monoatomic ion channel complex#GO:0034702;neuron to neuron synapse#GO:0098984;protein-containing complex#GO:0032991;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;plasma membrane#GO:0005886;postsynaptic specialization membrane#GO:0099634;postsynaptic membrane#GO:0045211;postsynaptic density#GO:0014069;transmembrane transporter complex#GO:1902495;postsynaptic density membrane#GO:0098839;postsynapse#GO:0098794;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cellular anatomical structure#GO:0110165;synapse#GO:0045202;asymmetric synapse#GO:0032279;organelle#GO:0043226 transmembrane signal receptor#PC00197 Ionotropic glutamate receptor pathway#P00037>NR2B#P01007;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>NMDA#P01071;Metabotropic glutamate receptor group III pathway#P00039>NMDA#P01039;Huntington disease#P00029>NMDA receptor#P00778;Metabotropic glutamate receptor group I pathway#P00041>NMDA#P01060;Ionotropic glutamate receptor pathway#P00037>NMDA#P01024 HUMAN|HGNC=18047|UniProtKB=Q9HB03 Q9HB03 ELOVL3 PTHR11157:SF68 FATTY ACID ACYL TRANSFERASE-RELATED VERY LONG CHAIN FATTY ACID ELONGASE 3 acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 oxoacid metabolic process#GO:0043436;very long-chain fatty acid metabolic process#GO:0000038;small molecule metabolic process#GO:0044281;carboxylic acid biosynthetic process#GO:0046394;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;monocarboxylic acid biosynthetic process#GO:0072330;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152;sphingolipid metabolic process#GO:0006665;sphingolipid biosynthetic process#GO:0030148;fatty acid metabolic process#GO:0006631;biosynthetic process#GO:0009058;fatty acid biosynthetic process#GO:0006633;lipid biosynthetic process#GO:0008610;cellular process#GO:0009987 membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;endoplasmic reticulum membrane#GO:0005789;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020 transferase#PC00220;acyltransferase#PC00042 HUMAN|HGNC=12407|UniProtKB=P68366 P68366 TUBA4A PTHR11588:SF53 TUBULIN TUBULIN ALPHA-4A CHAIN guanyl nucleotide binding#GO:0019001;nucleoside phosphate binding#GO:1901265;structural constituent of cytoskeleton#GO:0005200;binding#GO:0005488;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;structural molecule activity#GO:0005198;nucleotide binding#GO:0000166 generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;anatomical structure development#GO:0048856;microtubule cytoskeleton organization#GO:0000226;cell cycle#GO:0007049;cellular component organization#GO:0016043;cell differentiation#GO:0030154;mitotic cell cycle#GO:0000278;developmental process#GO:0032502;neuron differentiation#GO:0030182;microtubule-based process#GO:0007017;neurogenesis#GO:0022008;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;cellular process#GO:0009987;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;nervous system development#GO:0007399;multicellular organismal process#GO:0032501 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;microtubule#GO:0005874;microtubule cytoskeleton#GO:0015630;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;organelle#GO:0043226 tubulin#PC00228;cytoskeletal protein#PC00085 HUMAN|HGNC=4400|UniProtKB=P16520 P16520 GNB3 PTHR19850:SF31 GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)_G(S)_G(T) SUBUNIT BETA-3 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;signaling receptor complex adaptor activity#GO:0030159;signaling adaptor activity#GO:0035591 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 cytoplasm#GO:0005737;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020;extrinsic component of plasma membrane#GO:0019897;extrinsic component of membrane#GO:0019898;cytoplasmic side of membrane#GO:0098562;cellular anatomical structure#GO:0110165;plasma membrane protein complex#GO:0098797;cytoplasmic side of plasma membrane#GO:0009898;membrane protein complex#GO:0098796;intracellular anatomical structure#GO:0005622;side of membrane#GO:0098552;extrinsic component of cytoplasmic side of plasma membrane#GO:0031234;catalytic complex#GO:1902494 protein-binding activity modulator#PC00095;G-protein#PC00020;heterotrimeric G-protein#PC00117 Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>G-Protein#P01073;5HT4 type receptor mediated signaling pathway#P04376>G-protein#P04430;Metabotropic glutamate receptor group III pathway#P00039>G-Protein#P01045;Opioid proopiomelanocortin pathway#P05917>G-protein#P06012;Cortocotropin releasing factor receptor signaling pathway#P04380>G-Protein#P04458;Oxytocin receptor mediated signaling pathway#P04391>G-Protein#P04534;Angiotensin II-stimulated signaling through G proteins and beta-arrestin#P05911>Gbeta#P05930;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>G-Protein#P01085;Thyrotropin-releasing hormone receptor signaling pathway#P04394>G-Protein#P04584;5HT2 type receptor mediated signaling pathway#P04374>G-protein#P04416;Enkephalin release#P05913>G-Protein (i)#P05974;Gonadotropin-releasing hormone receptor pathway#P06664>Gbeta#P06769;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Gbetagamma#P00836;GABA-B receptor II signaling#P05731>Gbeta#P05755;Enkephalin release#P05913>G-Protein (s)#P05977;Histamine H2 receptor mediated signaling pathway#P04386>G-Protein#P04490;Beta2 adrenergic receptor signaling pathway#P04378>G-Protein#P04443;Histamine H1 receptor mediated signaling pathway#P04385>G-Protein#P04488;Opioid proenkephalin pathway#P05915>G-protein#P05994;Dopamine receptor mediated signaling pathway#P05912>Gbeta#P05954;Endogenous cannabinoid signaling#P05730>Gbeta#P05745;PI3 kinase pathway#P00048>Gbetagamma#P01188;5HT1 type receptor mediated signaling pathway#P04373>G-protein#P04408;Beta1 adrenergic receptor signaling pathway#P04377>G-Protein#P04436;Opioid prodynorphin pathway#P05916>G-protein#P06002;Beta3 adrenergic receptor signaling pathway#P04379>G-Protein#P04448;Metabotropic glutamate receptor group II pathway#P00040>G-protein#P01047;Wnt signaling pathway#P00057>GBeta#P01457;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GIRK#P00743 HUMAN|HGNC=12873|UniProtKB=O95409 O95409 ZIC2 PTHR19818:SF27 ZINC FINGER PROTEIN ZIC AND GLI ZINC FINGER PROTEIN ZIC 2 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;animal gross anatomical part developmental process#GO:0160108;regulation of transcription by RNA polymerase II#GO:0006357;central nervous system development#GO:0007417;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;multicellular organism development#GO:0007275;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;developmental process#GO:0032502;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;nervous system development#GO:0007399;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=18576|UniProtKB=P22674 P22674 CCNO PTHR10177:SF401 CYCLINS CYCLIN-O cyclin-dependent protein kinase regulator activity#GO:0019914;protein kinase regulator activity#GO:0019887;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;enzyme regulator activity#GO:0030234;cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538 cell cycle phase transition#GO:0044770;mitotic cell cycle#GO:0000278;cellular process#GO:0009987;cell cycle process#GO:0022402;cell cycle G1/S phase transition#GO:0044843;cell cycle#GO:0007049;mitotic cell cycle process#GO:1903047;G1/S transition of mitotic cell cycle#GO:0000082;mitotic cell cycle phase transition#GO:0044772 membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554;intracellular anatomical structure#GO:0005622;protein kinase complex#GO:1902911;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex#GO:1990234;transferase complex, transferring phosphorus-containing groups#GO:0061695;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634 kinase activator#PC00138 HUMAN|HGNC=11506|UniProtKB=P08247 P08247 SYP PTHR10306:SF10 SYNAPTOPHYSIN SYNAPTOPHYSIN regulation of biological quality#GO:0065008;regulation of neuronal synaptic plasticity#GO:0048168;regulation of signaling#GO:0023051;regulation of synaptic plasticity#GO:0048167;modulation of chemical synaptic transmission#GO:0050804;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;regulation of trans-synaptic signaling#GO:0099177;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789 membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;synapse#GO:0045202;vesicle#GO:0031982;synaptic vesicle membrane#GO:0030672;synaptic vesicle#GO:0008021;intracellular vesicle#GO:0097708;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;cell junction#GO:0030054;presynaptic active zone#GO:0048786;cytoplasm#GO:0005737;transport vesicle#GO:0030133;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;transport vesicle membrane#GO:0030658;presynapse#GO:0098793;vesicle membrane#GO:0012506;secretory vesicle#GO:0099503;membrane#GO:0016020 membrane traffic protein#PC00150;membrane trafficking regulatory protein#PC00151 Synaptic vesicle trafficking#P05734>Synaptophysin#P05777 HUMAN|HGNC=7619|UniProtKB=O60237 O60237 PPP1R12B PTHR24179:SF18 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12B enzyme inhibitor activity#GO:0004857;protein phosphatase regulator activity#GO:0019888;molecular function regulator activity#GO:0098772;molecular function inhibitor activity#GO:0140678;phosphatase regulator activity#GO:0019208;enzyme regulator activity#GO:0030234 system development#GO:0048731;neuron development#GO:0048666;anatomical structure development#GO:0048856;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell morphogenesis#GO:0000902;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;cell projection morphogenesis#GO:0048858;neurogenesis#GO:0022008;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;developmental process#GO:0032502;neuron differentiation#GO:0030182;neuron projection morphogenesis#GO:0048812;plasma membrane bounded cell projection morphogenesis#GO:0120039;plasma membrane bounded cell projection organization#GO:0120036;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;cellular process#GO:0009987;neuron projection development#GO:0031175 I band#GO:0031674;sarcomere#GO:0030017;membraneless organelle#GO:0043228;contractile muscle fiber#GO:0043292;Z disc#GO:0030018;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;intracellular organelle#GO:0043229;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;myofibril#GO:0030016;A band#GO:0031672;organelle#GO:0043226;cellular anatomical structure#GO:0110165 phosphatase modulator#PC00184;protein-binding activity modulator#PC00095 HUMAN|HGNC=2716|UniProtKB=O95865 O95865 DDAH2 PTHR12737:SF16 DIMETHYLARGININE DIMETHYLAMINOHYDROLASE HYDROLASE DDAH2-RELATED hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;catalytic activity#GO:0003824 regulation of biological process#GO:0050789;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;small molecule metabolic process#GO:0044281;regulation of cellular process#GO:0050794;oxoacid metabolic process#GO:0043436;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;arginine metabolic process#GO:0006525;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 hydrolase#PC00121 HUMAN|HGNC=17008|UniProtKB=Q92547 Q92547 TOPBP1 PTHR13561:SF20 DNA REPLICATION REGULATOR DPB11-RELATED DNA TOPOISOMERASE 2-BINDING PROTEIN 1 DNA metabolism protein#PC00009 HUMAN|HGNC=50289|UniProtKB=H0YM25 H0YM25 GOLGA6L22 PTHR23143:SF31 TRICHOHYALIN-RELATED GOLGIN SUBFAMILY A MEMBER 6-LIKE PROTEIN 1-RELATED actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=11340|UniProtKB=Q15532 Q15532 SS18 PTHR23107:SF2 SYNOVIAL SARCOMA ASSOCIATED SS18 PROTEIN PROTEIN SSXT transcription coactivator activity#GO:0003713;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of transcription by RNA polymerase II#GO:0045944 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 transcription cofactor#PC00217;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=9679|UniProtKB=Q9UMZ3 Q9UMZ3 PTPRQ PTHR46957:SF1 CYTOKINE RECEPTOR PHOSPHATIDYLINOSITOL PHOSPHATASE PTPRQ response to stimulus#GO:0050896;sensory perception of sound#GO:0007605;multicellular organismal process#GO:0032501;response to mechanical stimulus#GO:0009612;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;response to abiotic stimulus#GO:0009628;response to external stimulus#GO:0009605;system process#GO:0003008;sensory perception#GO:0007600;sensory perception of mechanical stimulus#GO:0050954;nervous system process#GO:0050877;detection of mechanical stimulus#GO:0050982 protein-containing complex#GO:0032991;signaling receptor complex#GO:0043235 transmembrane signal receptor#PC00197 HUMAN|HGNC=405|UniProtKB=P30838 P30838 ALDH3A1 PTHR43570:SF15 ALDEHYDE DEHYDROGENASE ALDEHYDE DEHYDROGENASE, DIMERIC NADP-PREFERRING aldehyde dehydrogenase (NAD+) activity#GO:0004029;oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor#GO:0016620;oxidoreductase activity, acting on the aldehyde or oxo group of donors#GO:0016903;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 aldehyde metabolic process#GO:0006081;cellular process#GO:0009987;metabolic process#GO:0008152 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;membrane#GO:0016020 dehydrogenase#PC00092 5-Hydroxytryptamine degredation#P04372>Aldehyde Dehydrogenase#P04402 HUMAN|HGNC=19341|UniProtKB=Q8IU85 Q8IU85 CAMK1D PTHR24347:SF252 SERINE/THREONINE-PROTEIN KINASE CALCIUM_CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 1D catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;calmodulin binding#GO:0005516;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein kinase activity#GO:0004672;protein binding#GO:0005515;phosphotransferase activity, alcohol group as acceptor#GO:0016773;calcium/calmodulin-dependent protein kinase activity#GO:0004683;protein serine/threonine kinase activity#GO:0004674;binding#GO:0005488 regulation of leukocyte migration#GO:0002685;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;signaling#GO:0023052;regulation of chemotaxis#GO:0050920;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;regulation of cell motility#GO:2000145;cell communication#GO:0007154;regulation of granulocyte chemotaxis#GO:0071622;regulation of response to external stimulus#GO:0032101;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;signal transduction#GO:0007165;regulation of neuron projection development#GO:0010975;cellular process#GO:0009987;regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of cell projection organization#GO:0031344;regulation of cell migration#GO:0030334;regulation of response to stimulus#GO:0048583 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=13077|UniProtKB=Q8N7M2 Q8N7M2 ZNF283 PTHR24377:SF63 IP01015P-RELATED ZINC FINGER PROTEIN 283 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=9462|UniProtKB=P60891 P60891 PRPS1 PTHR10210:SF128 RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 1 transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824 biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;carbohydrate derivative metabolic process#GO:1901135;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;ribose phosphate biosynthetic process#GO:0046390;nucleobase-containing small molecule metabolic process#GO:0055086;nucleoside phosphate biosynthetic process#GO:1901293;carbohydrate derivative biosynthetic process#GO:1901137;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;nucleotide metabolic process#GO:0009117;organophosphate biosynthetic process#GO:0090407;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;transferase complex#GO:1990234;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695 nucleotide kinase#PC00172;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=7405|UniProtKB=P80297 P80297 MT1X PTHR23299:SF62 METALLOTHIONEIN METALLOTHIONEIN-1X ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;metal ion binding#GO:0046872;cation binding#GO:0043169 intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;response to cadmium ion#GO:0046686;response to metal ion#GO:0010038;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;response to chemical#GO:0042221;detoxification#GO:0098754;monoatomic ion homeostasis#GO:0050801;response to stress#GO:0006950;detoxification of inorganic compound#GO:0061687;cellular process#GO:0009987;cellular response to chemical stimulus#GO:0070887;inorganic ion homeostasis#GO:0098771;response to stimulus#GO:0050896;response to toxic substance#GO:0009636;homeostatic process#GO:0042592;intracellular monoatomic ion homeostasis#GO:0006873;cellular response to stimulus#GO:0051716 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 defense/immunity protein#PC00090 HUMAN|HGNC=1955|UniProtKB=P02708 P02708 CHRNA1 PTHR18945:SF74 NEUROTRANSMITTER GATED ION CHANNEL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA ligand-gated monoatomic ion channel activity#GO:0015276;channel activity#GO:0015267;molecular transducer activity#GO:0060089;transmembrane transporter activity#GO:0022857;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;ligand-gated monoatomic cation channel activity#GO:0099094;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;monoatomic cation channel activity#GO:0005261;postsynaptic neurotransmitter receptor activity#GO:0098960;gated channel activity#GO:0022836;transmembrane signaling receptor activity#GO:0004888;acetylcholine receptor activity#GO:0015464;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;neurotransmitter receptor activity#GO:0030594;signaling receptor activity#GO:0038023;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 establishment of localization#GO:0051234;system process#GO:0003008;transport#GO:0006810;muscle contraction#GO:0006936;cellular response to nitrogen compound#GO:1901699;acetylcholine receptor signaling pathway#GO:0095500;multicellular organismal process#GO:0032501;synaptic transmission, cholinergic#GO:0007271;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;localization#GO:0051179;cell communication#GO:0007154;monoatomic cation transport#GO:0006812;response to nitrogen compound#GO:1901698;trans-synaptic signaling#GO:0099537;neuromuscular process#GO:0050905;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;regulation of cell communication#GO:0010646;striated muscle contraction#GO:0006941;metal ion transport#GO:0030001;modulation of chemical synaptic transmission#GO:0050804;membrane depolarization#GO:0051899;chemical synaptic transmission#GO:0007268;cellular response to stimulus#GO:0051716;regulation of membrane potential#GO:0042391;calcium ion transport#GO:0006816;neuromuscular synaptic transmission#GO:0007274;regulation of trans-synaptic signaling#GO:0099177;response to chemical#GO:0042221;synaptic signaling#GO:0099536;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;cellular response to chemical stimulus#GO:0070887;regulation of signaling#GO:0023051;nervous system process#GO:0050877;response to oxygen-containing compound#GO:1901700;response to stimulus#GO:0050896;signaling#GO:0023052;skeletal muscle contraction#GO:0003009;regulation of biological process#GO:0050789;muscle system process#GO:0003012 synapse#GO:0045202;cellular anatomical structure#GO:0110165;plasma membrane protein complex#GO:0098797;postsynapse#GO:0098794;membrane protein complex#GO:0098796;transmembrane transporter complex#GO:1902495;postsynaptic membrane#GO:0045211;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane region#GO:0098590;cell periphery#GO:0071944;membrane#GO:0016020;transporter complex#GO:1990351;cell junction#GO:0030054;synaptic membrane#GO:0097060;signaling receptor complex#GO:0043235 ligand-gated ion channel#PC00141 Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086;Nicotinic acetylcholine receptor signaling pathway#P00044>alpha#P01088 HUMAN|HGNC=45037|UniProtKB=B5MCY1 B5MCY1 TDRD15 PTHR22948:SF7 TUDOR DOMAIN CONTAINING PROTEIN TUDOR DOMAIN-CONTAINING PROTEIN 15 anatomical structure development#GO:0048856;multicellular organismal reproductive process#GO:0048609;piRNA processing#GO:0034587;pattern specification process#GO:0007389;sexual reproduction#GO:0019953;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;RNA biosynthetic process#GO:0032774;reproductive process#GO:0022414;nucleic acid metabolic process#GO:0090304;developmental process involved in reproduction#GO:0003006;primary metabolic process#GO:0044238;anatomical structure maturation#GO:0071695;germ cell development#GO:0007281;regulatory ncRNA processing#GO:0070918;macromolecule metabolic process#GO:0043170;cell maturation#GO:0048469;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;regulatory ncRNA-mediated gene silencing#GO:0031047;developmental process#GO:0032502;spermatogenesis#GO:0007283;developmental maturation#GO:0021700;regionalization#GO:0003002;male gamete generation#GO:0048232;multicellular organismal process#GO:0032501;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;cell differentiation#GO:0030154;gamete generation#GO:0007276;negative regulation of metabolic process#GO:0009892;cellular process involved in reproduction in multicellular organism#GO:0022412;cell development#GO:0048468;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;anterior/posterior axis specification#GO:0009948;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;anterior/posterior pattern specification#GO:0009952;cellular component assembly#GO:0022607;gene expression#GO:0010467;RNA processing#GO:0006396;oogenesis#GO:0048477;embryo development#GO:0009790;embryonic pattern specification#GO:0009880;organelle organization#GO:0006996;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;organelle#GO:0043226;intracellular organelle#GO:0043229;P granule#GO:0043186;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 scaffold/adaptor protein#PC00226 HUMAN|HGNC=2516|UniProtKB=Q9UQB3 Q9UQB3 CTNND2 PTHR10372:SF9 PLAKOPHILLIN-RELATED CATENIN DELTA-2 protein binding#GO:0005515;cell adhesion molecule binding#GO:0050839;binding#GO:0005488 neuron development#GO:0048666;dendrite development#GO:0016358;generation of neurons#GO:0048699;cell adhesion#GO:0007155;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;cell morphogenesis#GO:0000902;cell differentiation#GO:0030154;cell projection organization#GO:0030030;neuron projection organization#GO:0106027;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;cell projection morphogenesis#GO:0048858;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;cellular process#GO:0009987;dendritic spine organization#GO:0097061;cell-cell adhesion#GO:0098609;neuron projection development#GO:0031175;system development#GO:0048731;anatomical structure development#GO:0048856;synapse organization#GO:0050808;postsynapse organization#GO:0099173;cell junction organization#GO:0034330;dendritic spine morphogenesis#GO:0060997;dendritic spine development#GO:0060996;dendrite morphogenesis#GO:0048813;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;plasma membrane bounded cell projection organization#GO:0120036;multicellular organismal process#GO:0032501 postsynapse#GO:0098794;asymmetric synapse#GO:0032279;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;postsynaptic density#GO:0014069;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;cell-cell junction#GO:0005911;membrane#GO:0016020;nucleus#GO:0005634;cell periphery#GO:0071944;postsynaptic specialization#GO:0099572;neuron to neuron synapse#GO:0098984;plasma membrane#GO:0005886;cytoplasm#GO:0005737;cell junction#GO:0030054;adherens junction#GO:0005912 intermediate filament#PC00129;cytoskeletal protein#PC00085;intermediate filament binding protein#PC00130 Cadherin signaling pathway#P00012>P120#P00473 HUMAN|HGNC=19678|UniProtKB=Q9Y5K5 Q9Y5K5 UCHL5 PTHR10589:SF51 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5 peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;cysteine-type deubiquitinase activity#GO:0004843;cysteine-type peptidase activity#GO:0008234;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005 regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;biological regulation#GO:0065007;regulation of chromosome organization#GO:0033044;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protease#PC00190;protein modifying enzyme#PC00260;cysteine protease#PC00081 HUMAN|HGNC=2770|UniProtKB=P17661 P17661 DES PTHR45652:SF2 GLIAL FIBRILLARY ACIDIC PROTEIN DESMIN structural molecule activity#GO:0005198;structural constituent of cytoskeleton#GO:0005200 cellular component organization or biogenesis#GO:0071840;animal organ development#GO:0048513;muscle organ development#GO:0007517;developmental process#GO:0032502;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular process#GO:0009987;anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;intermediate filament-based process#GO:0045103;animal gross anatomical part developmental process#GO:0160108;skeletal muscle organ development#GO:0060538;intermediate filament organization#GO:0045109;intermediate filament cytoskeleton organization#GO:0045104;muscle structure development#GO:0061061;cellular component organization#GO:0016043 intermediate filament#GO:0005882;cell junction#GO:0030054;sarcolemma#GO:0042383;sarcomere#GO:0030017;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;I band#GO:0031674;cytoskeleton#GO:0005856;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;contractile muscle fiber#GO:0043292;Z disc#GO:0030018;cell periphery#GO:0071944;membrane#GO:0016020;cell-cell junction#GO:0005911;supramolecular fiber#GO:0099512;anchoring junction#GO:0070161;intracellular anatomical structure#GO:0005622;myofibril#GO:0030016;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165 intermediate filament#PC00129;cytoskeletal protein#PC00085 HUMAN|HGNC=26808|UniProtKB=Q8N1N2 Q8N1N2 DYNAP PTHR35349:SF7 DYNACTIN-ASSOCIATED PROTEIN DYNACTIN-ASSOCIATED PROTEIN regulation of cell population proliferation#GO:0042127;regulation of apoptotic process#GO:0042981;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of programmed cell death#GO:0043067;positive regulation of cell population proliferation#GO:0008284;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;positive regulation of biological process#GO:0048518 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;cell periphery#GO:0071944;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=28666|UniProtKB=Q9BQ75 Q9BQ75 CMSS1 PTHR24030:SF0 PROTEIN CMSS1 PROTEIN CMSS1 nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular process#GO:0009987;DNA replication#GO:0006260;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;DNA metabolic process#GO:0006259 RNA metabolism protein#PC00031 HUMAN|HGNC=28899|UniProtKB=Q86V85 Q86V85 GPR180 PTHR23252:SF29 INTIMAL THICKNESS RECEPTOR-RELATED INTEGRAL MEMBRANE PROTEIN GPR180 HUMAN|HGNC=11198|UniProtKB=O15370 O15370 SOX12 PTHR10270:SF221 SOX TRANSCRIPTION FACTOR TRANSCRIPTION FACTOR SOX-12 DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;sequence-specific DNA binding#GO:0043565;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription activator activity#GO:0001216;transcription regulator activity#GO:0140110;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;camera-type eye morphogenesis#GO:0048593;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;positive regulation of RNA biosynthetic process#GO:1902680;multicellular organismal process#GO:0032501;positive regulation of DNA-templated transcription#GO:0045893;brain development#GO:0007420;regulation of nucleobase-containing compound metabolic process#GO:0019219;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;sensory organ development#GO:0007423;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;positive regulation of RNA metabolic process#GO:0051254;visual system development#GO:0150063;regulation of cellular process#GO:0050794;animal organ morphogenesis#GO:0009887;regulation of macromolecule metabolic process#GO:0060255;camera-type eye development#GO:0043010;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;negative regulation of transcription by RNA polymerase II#GO:0000122;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;sensory system development#GO:0048880;negative regulation of macromolecule biosynthetic process#GO:0010558;head development#GO:0060322;nervous system development#GO:0007399;positive regulation of macromolecule metabolic process#GO:0010604;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;neuron differentiation#GO:0030182;positive regulation of transcription by RNA polymerase II#GO:0045944;animal organ development#GO:0048513;multicellular organism development#GO:0007275;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;sensory organ morphogenesis#GO:0090596;regulation of transcription by RNA polymerase II#GO:0006357;central nervous system development#GO:0007417;cell differentiation#GO:0030154;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;eye development#GO:0001654;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HMG box transcription factor#PC00024;gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HUMAN|HGNC=28344|UniProtKB=Q8NEQ5 Q8NEQ5 C1orf162 PTHR37997:SF1 TRANSMEMBRANE PROTEIN C1ORF162 TRANSMEMBRANE PROTEIN C1ORF162 HUMAN|HGNC=25719|UniProtKB=Q96C57 Q96C57 CUSTOS PTHR14482:SF0 CHROMOSOME 12 ORF 43 HOMOLOG PROTEIN CUSTOS anatomical structure development#GO:0048856;negative regulation of cell communication#GO:0010648;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;anatomical structure formation involved in morphogenesis#GO:0048646;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;developmental process#GO:0032502;negative regulation of response to stimulus#GO:0048585;negative regulation of Wnt signaling pathway#GO:0030178;negative regulation of signal transduction#GO:0009968;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966 HUMAN|HGNC=20889|UniProtKB=O94898 O94898 LRIG2 PTHR24373:SF306 SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 2 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 system process#GO:0003008;multicellular organismal process#GO:0032501;sensory perception of sound#GO:0007605;nervous system process#GO:0050877;sensory perception#GO:0007600;sensory perception of mechanical stimulus#GO:0050954 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=8685|UniProtKB=Q9Y5E9 Q9Y5E9 PCDHB14 PTHR24028:SF81 CADHERIN-87A PROTOCADHERIN BETA-14 cell adhesion#GO:0007155;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 cadherin#PC00057;cell adhesion molecule#PC00069 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HUMAN|HGNC=14398|UniProtKB=Q9GZT4 Q9GZT4 SRR PTHR43050:SF3 SERINE / THREONINE RACEMASE FAMILY MEMBER SERINE RACEMASE nucleotide binding#GO:0000166;isomerase activity#GO:0016853;catalytic activity#GO:0003824;cation binding#GO:0043169;magnesium ion binding#GO:0000287;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;carbohydrate derivative binding#GO:0097367;racemase and epimerase activity#GO:0016854;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;ribonucleotide binding#GO:0032553;lyase activity#GO:0016829;metal ion binding#GO:0046872;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;ATP binding#GO:0005524 carboxylic acid biosynthetic process#GO:0046394;cellular process#GO:0009987;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;small molecule metabolic process#GO:0044281;small molecule biosynthetic process#GO:0044283;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;amino acid biosynthetic process#GO:0008652 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;epimerase/racemase#PC00096 HUMAN|HGNC=14367|UniProtKB=Q8TDM0 Q8TDM0 BCAS4 PTHR16230:SF5 CAPPUCCINO BREAST CARCINOMA-AMPLIFIED SEQUENCE 4 cellular pigmentation#GO:0033059;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;vesicle organization#GO:0016050;cellular component organization or biogenesis#GO:0071840;pigmentation#GO:0043473;melanosome organization#GO:0032438 intracellular protein-containing complex#GO:0140535;BLOC-1 complex#GO:0031083;protein-containing complex#GO:0032991 HUMAN|HGNC=3575|UniProtKB=O95864 O95864 FADS2 PTHR19353:SF12 FATTY ACID DESATURASE 2 ACYL-COA 6-DESATURASE oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705 metabolic process#GO:0008152;primary metabolic process#GO:0044238;cellular process#GO:0009987;lipid metabolic process#GO:0006629 cellular anatomical structure#GO:0110165;membrane#GO:0016020 oxidoreductase#PC00176 HUMAN|HGNC=29117|UniProtKB=Q2TBF2 Q2TBF2 WSCD2 PTHR45964:SF9 WSCD FAMILY MEMBER CG9164 SIALATE:O-SULFOTRANSFERASE 2 HUMAN|HGNC=20987|UniProtKB=Q9P2S6 Q9P2S6 ANKMY1 PTHR15897:SF2 ANKYRIN REPEAT AND MYND DOMAIN PROTEIN 1 ANKYRIN REPEAT AND MYND DOMAIN-CONTAINING PROTEIN 1 HUMAN|HGNC=24588|UniProtKB=Q86XP6 Q86XP6 GKN2 PTHR16483:SF3 GASTROKINE 1 GASTROKINE-2 regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cell population proliferation#GO:0042127;biological regulation#GO:0065007 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=34297|UniProtKB=A8MYJ7 A8MYJ7 TTC34 PTHR44874:SF1 TETRATRICOPEPTIDE REPEAT PROTEIN 34 TETRATRICOPEPTIDE REPEAT PROTEIN 34 HUMAN|HGNC=2193|UniProtKB=Q07092 Q07092 COL16A1 PTHR24023:SF372 COLLAGEN ALPHA COLLAGEN ALPHA-1(XVI) CHAIN extracellular matrix structural constituent#GO:0005201;structural molecule activity#GO:0005198 cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;external encapsulating structure organization#GO:0045229;cellular component organization#GO:0016043;extracellular structure organization#GO:0043062;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;basement membrane#GO:0005604;extracellular region#GO:0005576 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 Integrin signalling pathway#P00034>Collagen#P00922 HUMAN|HGNC=4119|UniProtKB=Q01415 Q01415 GALK2 PTHR10457:SF7 MEVALONATE KINASE/GALACTOKINASE GALACTOKINASE-RELATED phosphotransferase activity, alcohol group as acceptor#GO:0016773;carbohydrate kinase activity#GO:0019200;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 cellular process#GO:0009987;monosaccharide metabolic process#GO:0005996;hexose metabolic process#GO:0019318;primary metabolic process#GO:0044238;metabolic process#GO:0008152;carbohydrate metabolic process#GO:0005975;small molecule metabolic process#GO:0044281 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 transferase#PC00220;carbohydrate kinase#PC00065;metabolite interconversion enzyme#PC00262;kinase#PC00137 Fructose galactose metabolism#P02744>Galactokinase#P02960 HUMAN|HGNC=21194|UniProtKB=Q5JWR5 Q5JWR5 DOP1A PTHR14042:SF22 DOPEY-RELATED PROTEIN DOP1A establishment of localization in cell#GO:0051649;cellular process#GO:0009987;intra-Golgi vesicle-mediated transport#GO:0006891;retrograde transport, endosome to Golgi#GO:0042147;retrograde transport, vesicle recycling within Golgi#GO:0000301;cytosolic transport#GO:0016482;vesicle-mediated transport#GO:0016192;transport#GO:0006810;Golgi vesicle transport#GO:0048193;intracellular transport#GO:0046907;endosomal transport#GO:0016197;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular vesicle#GO:0097708;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;endomembrane system#GO:0012505;Golgi apparatus subcompartment#GO:0098791;Golgi apparatus#GO:0005794 HUMAN|HGNC=6899|UniProtKB=P04201 P04201 MAS1 PTHR11334:SF61 MAS-RELATED G-PROTEIN COUPLED RECEPTOR PROTO-ONCOGENE MAS molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=26291|UniProtKB=Q8TAM1 Q8TAM1 BBS10 PTHR14667:SF2 BARDET-BIEDL SYNDROME 10 PROTEIN BBSOME COMPLEX ASSEMBLY PROTEIN BBS10 protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;cellular component assembly#GO:0022607;chaperone-mediated protein complex assembly#GO:0051131;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840 HUMAN|HGNC=672|UniProtKB=P84095 P84095 RHOG PTHR24072:SF158 RHO FAMILY GTPASE RHO-RELATED GTP-BINDING PROTEIN RHOG heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;protein binding#GO:0005515;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;kinase binding#GO:0019900;binding#GO:0005488;protein kinase binding#GO:0019901;guanyl nucleotide binding#GO:0019001;enzyme binding#GO:0019899;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;GTPase activity#GO:0003924;ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168 biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;cell migration#GO:0016477;actin filament organization#GO:0007015;response to external stimulus#GO:0009605;regulation of actin filament-based process#GO:0032970;locomotion#GO:0040011;regulation of developmental process#GO:0050793;cell motility#GO:0048870;regulation of cellular process#GO:0050794;actin cytoskeleton organization#GO:0030036;regulation of cytoskeleton organization#GO:0051493;cellular response to stimulus#GO:0051716;intracellular signal transduction#GO:0035556;cell chemotaxis#GO:0060326;supramolecular fiber organization#GO:0097435;cell communication#GO:0007154;actin filament-based process#GO:0030029;chemotaxis#GO:0006935;cortical cytoskeleton organization#GO:0030865;intracellular signaling cassette#GO:0141124;regulation of actin cytoskeleton organization#GO:0032956;cytoskeleton organization#GO:0007010;taxis#GO:0042330;response to chemical#GO:0042221;cellular process#GO:0009987;signal transduction#GO:0007165;organelle organization#GO:0006996;regulation of anatomical structure morphogenesis#GO:0022603;cellular component organization or biogenesis#GO:0071840;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular component organization#GO:0051128;regulation of cell shape#GO:0008360;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;regulation of biological quality#GO:0065008;Rac protein signal transduction#GO:0016601;establishment or maintenance of cell polarity#GO:0007163;cellular response to chemical stimulus#GO:0070887 cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;membrane#GO:0016020;cell periphery#GO:0071944;cytoplasm#GO:0005737;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cell projection#GO:0042995 small GTPase#PC00208;G-protein#PC00020 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Cdc42#P00834;Huntington disease#P00029>Rac#P00775;EGF receptor signaling pathway#P00018>Rac#P00564 HUMAN|HGNC=25517|UniProtKB=Q9H583 Q9H583 HEATR1 PTHR13457:SF1 BAP28 HEAT REPEAT-CONTAINING PROTEIN 1 nucleic acid binding#GO:0003676;binding#GO:0005488;snoRNA binding#GO:0030515;RNA binding#GO:0003723 ribonucleoprotein complex biogenesis#GO:0022613;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;regulation of biological process#GO:0050789;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;RNA metabolic process#GO:0016070;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;positive regulation of macromolecule metabolic process#GO:0010604;gene expression#GO:0010467;RNA processing#GO:0006396;maturation of SSU-rRNA#GO:0030490;cellular component biogenesis#GO:0044085;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;ribosomal small subunit biogenesis#GO:0042274;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;RNA biosynthetic process#GO:0032774;positive regulation of RNA metabolic process#GO:0051254;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;rRNA processing#GO:0006364;regulation of transcription by RNA polymerase I#GO:0006356;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of transcription by RNA polymerase I#GO:0045943;biological regulation#GO:0065007;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;rRNA metabolic process#GO:0016072 nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;preribosome#GO:0030684;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;mitochondrion#GO:0005739;small-subunit processome#GO:0032040 RNA metabolism protein#PC00031 HUMAN|HGNC=20576|UniProtKB=Q6UW02 Q6UW02 CYP20A1 PTHR24280:SF4 CYTOCHROME P450 20A1 CYTOCHROME P450 20A1 oxygenase#PC00177 HUMAN|HGNC=26119|UniProtKB=Q9BRV8 Q9BRV8 SIKE1 PTHR12186:SF4 SIKE FAMILY MEMBER SUPPRESSOR OF IKBKE 1 HUMAN|HGNC=11374|UniProtKB=O76061 O76061 STC2 PTHR11245:SF2 STANNIOCALCIN STANNIOCALCIN-2 calcium ion homeostasis#GO:0055074;inorganic ion homeostasis#GO:0098771;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;chemical homeostasis#GO:0048878;cellular homeostasis#GO:0019725;intracellular calcium ion homeostasis#GO:0006874;intracellular chemical homeostasis#GO:0055082;monoatomic ion homeostasis#GO:0050801;intracellular monoatomic ion homeostasis#GO:0006873;homeostatic process#GO:0042592 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 peptide hormone#PC00179 HUMAN|HGNC=6366|UniProtKB=Q9Y337 Q9Y337 KLK5 PTHR24271:SF59 KALLIKREIN-RELATED KALLIKREIN-5 serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;serine-type peptidase activity#GO:0008236;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604 cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;extracellular region#GO:0005576;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;secretory vesicle#GO:0099503;intracellular vesicle#GO:0097708 serine protease#PC00203 HUMAN|HGNC=742|UniProtKB=P07306 P07306 ASGR1 PTHR22802:SF470 C-TYPE LECTIN SUPERFAMILY MEMBER ASIALOGLYCOPROTEIN RECEPTOR 1 signaling receptor activity#GO:0038023;pattern recognition receptor activity#GO:0038187;carbohydrate binding#GO:0030246;molecular transducer activity#GO:0060089;binding#GO:0005488 response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell surface#GO:0009986;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;membrane#GO:0016020 membrane traffic protein#PC00150 HUMAN|HGNC=8869|UniProtKB=Q99471 Q99471 PFDN5 PTHR12674:SF6 PREFOLDIN SUBUNIT 5 PREFOLDIN SUBUNIT 5 cellular component assembly#GO:0022607;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 chaperone#PC00072 HUMAN|HGNC=25578|UniProtKB=Q86V59 Q86V59 PNMA8A PTHR23095:SF21 PARANEOPLASTIC ANTIGEN PARANEOPLASTIC ANTIGEN-LIKE PROTEIN 8A transcription cofactor#PC00217 HUMAN|HGNC=18054|UniProtKB=Q96T91 Q96T91 GPHA2 PTHR31129:SF3 GLYCOPROTEIN HORMONE ALPHA-2 GLYCOPROTEIN HORMONE ALPHA-2 protein binding#GO:0005515;G protein-coupled receptor binding#GO:0001664;signaling receptor binding#GO:0005102;hormone receptor binding#GO:0051427;binding#GO:0005488 signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 peptide hormone#PC00179 HUMAN|HGNC=9534|UniProtKB=P28066 P28066 PSMA5 PTHR11599:SF14 PROTEASOME SUBUNIT ALPHA/BETA PROTEASOME SUBUNIT ALPHA TYPE-5 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987 endopeptidase complex#GO:1905369;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;proteasome complex#GO:0000502;nucleus#GO:0005634;peptidase complex#GO:1905368;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;protease#PC00190 Parkinson disease#P00049>20S proteasome#P01227 HUMAN|HGNC=28030|UniProtKB=Q6PKC3 Q6PKC3 TXNDC11 PTHR46497:SF1 THIOREDOXIN DOMAIN-CONTAINING PROTEIN 11 THIOREDOXIN DOMAIN-CONTAINING PROTEIN 11 oxidoreductase#PC00176 HUMAN|HGNC=24499|UniProtKB=Q8NE09 Q8NE09 RGS22 PTHR46583:SF1 REGULATOR OF G-PROTEIN SIGNALING 22 REGULATOR OF G PROTEIN SIGNALING 22 binding#GO:0005488;protein binding#GO:0005515 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=21421|UniProtKB=Q8NA23 Q8NA23 WDR31 PTHR19869:SF1 SPERMATID WD-REPEAT PROTEIN WD REPEAT-CONTAINING PROTEIN 31 HUMAN|HGNC=6730|UniProtKB=Q9HBG7 Q9HBG7 LY9 PTHR12080:SF114 SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE T-LYMPHOCYTE SURFACE ANTIGEN LY-9 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 lymphocyte activation#GO:0046649;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;immune response#GO:0006955;signal transduction#GO:0007165;cellular process#GO:0009987;cell communication#GO:0007154;immune system process#GO:0002376;cell activation#GO:0001775;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;leukocyte activation#GO:0045321;T cell activation#GO:0042110;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=1975|UniProtKB=P58304 P58304 VSX2 PTHR46892:SF1 VISUAL SYSTEM HOMEOBOX 2 VISUAL SYSTEM HOMEOBOX 2 DNA binding#GO:0003677;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;sequence-specific DNA binding#GO:0043565;binding#GO:0005488;nucleic acid binding#GO:0003676 regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 homeodomain transcription factor#PC00119 HUMAN|HGNC=23149|UniProtKB=Q8NB66 Q8NB66 UNC13C PTHR10480:SF2 PROTEIN UNC-13 HOMOLOG PROTEIN UNC-13 HOMOLOG C SNARE binding#GO:0000149;calmodulin binding#GO:0005516;binding#GO:0005488;protein binding#GO:0005515;syntaxin binding#GO:0019905 cellular localization#GO:0051641;secretion by cell#GO:0032940;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;regulation of biological process#GO:0050789;establishment of organelle localization#GO:0051656;signaling#GO:0023052;export from cell#GO:0140352;regulated exocytosis#GO:0045055;exocytic process#GO:0140029;cellular component organization or biogenesis#GO:0071840;vesicle-mediated transport in synapse#GO:0099003;exocytosis#GO:0006887;protein-containing complex organization#GO:0043933;cellular component biogenesis#GO:0044085;synaptic signaling#GO:0099536;establishment of localization in cell#GO:0051649;synaptic vesicle exocytosis#GO:0016079;cellular process#GO:0009987;cellular component assembly#GO:0022607;vesicle-mediated transport#GO:0016192;neurotransmitter transport#GO:0006836;establishment of vesicle localization#GO:0051650;synaptic transmission, glutamatergic#GO:0035249;signal release#GO:0023061;trans-synaptic signaling#GO:0099537;organelle localization#GO:0051640;localization#GO:0051179;cell communication#GO:0007154;secretion#GO:0046903;signal release from synapse#GO:0099643;chemical synaptic transmission#GO:0007268;anterograde trans-synaptic signaling#GO:0098916;calcium-ion regulated exocytosis#GO:0017156;transport#GO:0006810;synaptic vesicle cycle#GO:0099504;establishment of localization#GO:0051234;vesicle localization#GO:0051648;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;neurotransmitter secretion#GO:0007269 presynaptic membrane#GO:0042734;plasma membrane#GO:0005886;endomembrane system#GO:0012505;transport vesicle membrane#GO:0030658;transport vesicle#GO:0030133;plasma membrane region#GO:0098590;cell periphery#GO:0071944;membrane#GO:0016020;vesicle membrane#GO:0012506;axon terminus#GO:0043679;organelle membrane#GO:0031090;neuromuscular junction#GO:0031594;distal axon#GO:0150034;terminal bouton#GO:0043195;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;neuron projection terminus#GO:0044306;synaptic vesicle#GO:0008021;vesicle#GO:0031982;synaptic vesicle membrane#GO:0030672;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;axon#GO:0030424;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;neuron projection#GO:0043005;presynapse#GO:0098793;secretory vesicle#GO:0099503;bounding membrane of organelle#GO:0098588;cell junction#GO:0030054;synaptic membrane#GO:0097060;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;intracellular vesicle#GO:0097708;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229 Synaptic vesicle trafficking#P05734>Munc13#P05773 HUMAN|HGNC=10585|UniProtKB=P35498 P35498 SCN1A PTHR10037:SF280 VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM SODIUM CHANNEL PROTEIN TYPE 1 SUBUNIT ALPHA channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;voltage-gated sodium channel activity#GO:0005248;monoatomic cation channel activity#GO:0005261;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;sodium channel activity#GO:0005272;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803 multicellular organismal process#GO:0032501;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;biological regulation#GO:0065007;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;transmission of nerve impulse#GO:0019226;system process#GO:0003008;transport#GO:0006810;membrane depolarization#GO:0051899;metal ion transport#GO:0030001;sensory perception of pain#GO:0019233;sodium ion transport#GO:0006814;action potential#GO:0001508;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;cell communication#GO:0007154;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;nervous system process#GO:0050877;sensory perception#GO:0007600 axon#GO:0030424;sodium channel complex#GO:0034706;transmembrane transporter complex#GO:1902495;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165;cation channel complex#GO:0034703;transporter complex#GO:1990351;neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991 voltage-gated ion channel#PC00241 HUMAN|HGNC=9565|UniProtKB=P51665 P51665 PSMD7 PTHR10540:SF12 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7 ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238 peptidase complex#GO:1905368;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;proteasome complex#GO:0000502;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;catalytic complex#GO:1902494;endopeptidase complex#GO:1905369;proteasome regulatory particle, lid subcomplex#GO:0008541 translation initiation factor#PC00224 Cell cycle#P00013>Proteasome#P00480;Ubiquitin proteasome pathway#P00060>26S proteasome#P01489 HUMAN|HGNC=29225|UniProtKB=Q9ULJ1 Q9ULJ1 ODF2L PTHR23162:SF7 OUTER DENSE FIBER OF SPERM TAILS 2 PROTEIN BCAP regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of cilium assembly#GO:1902017;negative regulation of cellular process#GO:0048523;regulation of cell projection organization#GO:0031344;biological regulation#GO:0065007;regulation of organelle assembly#GO:1902115;regulation of cell projection assembly#GO:0060491;regulation of cellular component biogenesis#GO:0044087;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of plasma membrane bounded cell projection assembly#GO:0120032;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;negative regulation of cellular component organization#GO:0051129;negative regulation of organelle organization#GO:0010639;negative regulation of biological process#GO:0048519 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cilium#GO:0005929;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;centrosome#GO:0005813;microtubule organizing center#GO:0005815;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;microtubule cytoskeleton#GO:0015630 HUMAN|HGNC=30378|UniProtKB=O60645 O60645 EXOC3 PTHR21292:SF13 EXOCYST COMPLEX COMPONENT SEC6-RELATED EXOCYST COMPLEX COMPONENT 3 protein binding#GO:0005515;SNARE binding#GO:0000149;binding#GO:0005488 secretion by cell#GO:0032940;exocytosis#GO:0006887;localization#GO:0051179;establishment of localization#GO:0051234;secretion#GO:0046903;transport#GO:0006810;export from cell#GO:0140352;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987 vesicle tethering complex#GO:0099023;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;exocyst#GO:0000145;cell cortex#GO:0005938;cell periphery#GO:0071944 membrane traffic protein#PC00150 HUMAN|HGNC=11838|UniProtKB=Q04725 Q04725 TLE2 PTHR10814:SF4 TRANSDUCIN-LIKE ENHANCER PROTEIN TRANSDUCIN-LIKE ENHANCER PROTEIN 2 transcription regulator activity#GO:0140110;transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712 regulation of Wnt signaling pathway#GO:0030111;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of cell communication#GO:0010648;regulation of signaling#GO:0023051;negative regulation of canonical Wnt signaling pathway#GO:0090090;negative regulation of signaling#GO:0023057;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of signal transduction#GO:0009968;negative regulation of response to stimulus#GO:0048585;negative regulation of Wnt signaling pathway#GO:0030178;regulation of canonical Wnt signaling pathway#GO:0060828;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 transcription cofactor#PC00217 Wnt signaling pathway#P00057>Transducin-like Enhance of Split 1-3#P01436 HUMAN|HGNC=4652|UniProtKB=P35269 P35269 GTF2F1 PTHR13011:SF0 TFIIF-ALPHA GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 1 RNA polymerase II complex binding#GO:0000993;protein binding#GO:0005515;RNA polymerase core enzyme binding#GO:0043175;transcription factor binding#GO:0008134;binding#GO:0005488;enzyme binding#GO:0019899;RNA polymerase binding#GO:0070063 biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;transcription initiation at RNA polymerase II promoter#GO:0006367;macromolecule metabolic process#GO:0043170;transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;DNA-templated transcription initiation#GO:0006352;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187 organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;RNA polymerase II, holoenzyme#GO:0016591;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;transcription regulator complex#GO:0005667 general transcription factor#PC00259;RNA metabolism protein#PC00031 General transcription regulation#P00023>TFIIFalpha#P00663;Transcription regulation by bZIP transcription factor#P00055>TFIIFalpha#P01391 HUMAN|HGNC=21230|UniProtKB=Q9P1F3 Q9P1F3 ABRACL PTHR46334:SF1 COSTARS FAMILY PROTEIN ABRACL COSTARS FAMILY PROTEIN ABRACL regulation of actin filament-based process#GO:0032970;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;biological regulation#GO:0065007 HUMAN|HGNC=9391|UniProtKB=P13861 P13861 PRKAR2A PTHR11635:SF153 CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT protein kinase binding#GO:0019901;enzyme binding#GO:0019899;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;kinase binding#GO:0019900;molecular function inhibitor activity#GO:0140678;protein binding#GO:0005515;enzyme regulator activity#GO:0030234;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;protein kinase A binding#GO:0051018;purine nucleotide binding#GO:0017076;kinase regulator activity#GO:0019207;protein kinase regulator activity#GO:0019887;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;kinase inhibitor activity#GO:0019210;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;enzyme inhibitor activity#GO:0004857;nucleotide binding#GO:0000166;molecular function regulator activity#GO:0098772;protein kinase inhibitor activity#GO:0004860 adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytosol#GO:0005829;serine/threonine protein kinase complex#GO:1902554;intracellular anatomical structure#GO:0005622;protein kinase complex#GO:1902911;intracellular protein-containing complex#GO:0140535;catalytic complex#GO:1902494;transferase complex#GO:1990234;transferase complex, transferring phosphorus-containing groups#GO:0061695 kinase modulator#PC00140;protein-binding activity modulator#PC00095 Enkephalin release#P05913>PKA#P05972;Metabotropic glutamate receptor group III pathway#P00039>PKA#P01035;Beta1 adrenergic receptor signaling pathway#P04377>PKA#P04437;GABA-B receptor II signaling#P05731>PKA#P05752;Endothelin signaling pathway#P00019>PKA#P00570;Beta2 adrenergic receptor signaling pathway#P04378>PKA#P04444;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>PKA-r#P00700;Metabotropic glutamate receptor group II pathway#P00040>PKA#P01050;5HT1 type receptor mediated signaling pathway#P04373>PKA#P04403;Dopamine receptor mediated signaling pathway#P05912>PKA#P05946;Hedgehog signaling pathway#P00025>PKA#P00682;Transcription regulation by bZIP transcription factor#P00055>PKA#P01384;Histamine H2 receptor mediated signaling pathway#P04386>PKA#P04491;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>PKA#P01075 HUMAN|HGNC=14311|UniProtKB=O60285 O60285 NUAK1 PTHR24343:SF350 SERINE/THREONINE KINASE NUAK FAMILY SNF1-LIKE KINASE 1 catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=11744|UniProtKB=Q92754 Q92754 TFAP2C PTHR10812:SF9 TRANSCRIPTION FACTOR AP-2 TRANSCRIPTION FACTOR AP-2 GAMMA DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription activator activity#GO:0001216;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228 regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of cell population proliferation#GO:0042127;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of DNA-templated transcription#GO:0006355;positive regulation of RNA metabolic process#GO:0051254;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 general transcription factor#PC00259;RNA metabolism protein#PC00031 HUMAN|HGNC=4687|UniProtKB=Q02153 Q02153 GUCY1B1 PTHR45655:SF2 GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2 GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-1 catalytic activity#GO:0003824;phosphorus-oxygen lyase activity#GO:0016849;cyclase activity#GO:0009975;lyase activity#GO:0016829;guanylate cyclase activity#GO:0004383 biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;carbohydrate derivative metabolic process#GO:1901135;cGMP metabolic process#GO:0046068;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;nucleoside phosphate biosynthetic process#GO:1901293;cyclic nucleotide metabolic process#GO:0009187;nucleoside phosphate metabolic process#GO:0006753;response to oxygen levels#GO:0070482;primary metabolic process#GO:0044238;cGMP biosynthetic process#GO:0006182;organophosphate biosynthetic process#GO:0090407;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;ribose phosphate biosynthetic process#GO:0046390;nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative biosynthetic process#GO:1901137;cyclic purine nucleotide metabolic process#GO:0052652;metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing compound biosynthetic process#GO:0034654;response to stimulus#GO:0050896;small molecule metabolic process#GO:0044281;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;response to abiotic stimulus#GO:0009628;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;cyclic nucleotide biosynthetic process#GO:0009190;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;ribonucleotide metabolic process#GO:0009259 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829;catalytic complex#GO:1902494 guanylate cyclase#PC00114;cyclase#PC00079 Endothelin signaling pathway#P00019>Guanylate cyclase#P00581;Gonadotropin-releasing hormone receptor pathway#P06664>GC#P06726 HUMAN|HGNC=12969|UniProtKB=P17022 P17022 ZNF18 PTHR23226:SF190 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER PROTEIN 18 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=34333|UniProtKB=Q6ZNA1 Q6ZNA1 ZNF836 PTHR24376:SF128 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 836-RELATED regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;negative regulation of metabolic process#GO:0009892;negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=20258|UniProtKB=Q8TEB1 Q8TEB1 DCAF11 PTHR19847:SF7 DDB1- AND CUL4-ASSOCIATED FACTOR 11 DDB1- AND CUL4-ASSOCIATED FACTOR 11 ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238 Cul4-RING E3 ubiquitin ligase complex#GO:0080008;transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=25553|UniProtKB=Q9NVN8 Q9NVN8 GNL3L PTHR11089:SF33 GTP-BINDING PROTEIN-RELATED GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 3-LIKE PROTEIN nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228 HUMAN|HGNC=31257|UniProtKB=Q8NGX2 Q8NGX2 OR2T35 PTHR26453:SF18 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2T2-RELATED transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 system process#GO:0003008;nervous system process#GO:0050877;sensory perception#GO:0007600;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;response to chemical#GO:0042221;response to stimulus#GO:0050896;detection of chemical stimulus#GO:0009593;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|Ensembl=ENSG00000283722.3|UniProtKB=A0A191URJ7 A0A191URJ7 PTHR11738:SF189 MHC CLASS I NK CELL RECEPTOR IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN-RELATED transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;immune receptor activity#GO:0140375 signaling#GO:0023052;immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;immune response-regulating signaling pathway#GO:0002764;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;regulation of response to stimulus#GO:0048583;regulation of immune response#GO:0050776 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=33853|UniProtKB=Q9H1A7 Q9H1A7 POLR2J3 PTHR13946:SF48 DNA-DIRECTED RNA POLYMERASE I,II,III DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11-B1-RELATED transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a nucleic acid#GO:0140640;nucleotidyltransferase activity#GO:0016779;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on RNA#GO:0140098 DNA-templated transcription#GO:0006351;biosynthetic process#GO:0009058;RNA biosynthetic process#GO:0032774;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;macromolecule metabolic process#GO:0043170;transcription by RNA polymerase II#GO:0006366;nucleic acid biosynthetic process#GO:0141187;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;RNA polymerase II, core complex#GO:0005665;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;membrane-bounded organelle#GO:0043227;RNA polymerase II, holoenzyme#GO:0016591;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;protein-containing complex#GO:0032991;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;membrane-enclosed lumen#GO:0031974;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234 DNA-directed RNA polymerase#PC00019;RNA metabolism protein#PC00031 HUMAN|HGNC=18666|UniProtKB=Q96LT9 Q96LT9 RNPC3 PTHR16105:SF7 RNA-BINDING REGION-CONTAINING PROTEIN 3 RNA-BINDING REGION-CONTAINING PROTEIN 3 pre-mRNA binding#GO:0036002;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723;snRNA binding#GO:0017069 RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;mRNA splicing, via spliceosome#GO:0000398;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397 intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;spliceosomal complex#GO:0005681;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;U12-type spliceosomal complex#GO:0005689;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904 HUMAN|HGNC=6136|UniProtKB=Q9UKX5 Q9UKX5 ITGA11 PTHR23220:SF21 INTEGRIN ALPHA INTEGRIN ALPHA-11 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;integrin-mediated signaling pathway#GO:0007229;cell-cell adhesion#GO:0098609;cell-substrate adhesion#GO:0031589;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;cell-matrix adhesion#GO:0007160;cell adhesion#GO:0007155 signaling receptor complex#GO:0043235;integrin complex#GO:0008305;protein complex involved in cell adhesion#GO:0098636;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cell surface#GO:0009986 integrin#PC00126;cell adhesion molecule#PC00069 Integrin signalling pathway#P00034>Integrin alpha#P00941 HUMAN|HGNC=2357|UniProtKB=P34998 P34998 CRHR1 PTHR45620:SF2 PDF RECEPTOR-LIKE PROTEIN-RELATED CORTICOTROPIN-RELEASING HORMONE RECEPTOR 1 hormone binding#GO:0042562;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;signaling receptor activity#GO:0038023;peptide hormone binding#GO:0017046;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;molecular transducer activity#GO:0060089 cell communication#GO:0007154;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789 plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;neuron projection#GO:0043005;membrane#GO:0016020 transmembrane signal receptor#PC00197 Cortocotropin releasing factor receptor signaling pathway#P04380>CRHR1#P04451 HUMAN|HGNC=17272|UniProtKB=Q9HC77 Q9HC77 CPAP PTHR10331:SF23 T COMPLEX PROTEIN 10 CENTROSOMAL P4.1-ASSOCIATED PROTEIN protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;binding#GO:0005488 cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection organization#GO:0120036;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;microtubule organizing center organization#GO:0031023;centrosome duplication#GO:0051298;microtubule-based process#GO:0007017;plasma membrane bounded cell projection assembly#GO:0120031;cell projection organization#GO:0030030;cell cycle#GO:0007049;membraneless organelle assembly#GO:0140694;cilium assembly#GO:0060271;cellular component organization#GO:0016043;centrosome cycle#GO:0007098;cell cycle process#GO:0022402;microtubule cytoskeleton organization#GO:0000226;cilium organization#GO:0044782;organelle assembly#GO:0070925;centriole replication#GO:0007099 intracellular organelle#GO:0043229;microtubule organizing center#GO:0005815;centrosome#GO:0005813;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;centriole#GO:0005814;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165 microtubule or microtubule-binding cytoskeletal protein#PC00157;cytoskeletal protein#PC00085 HUMAN|HGNC=17179|UniProtKB=Q7L3B6 Q7L3B6 CDC37L1 PTHR12800:SF2 CDC37-RELATED HSP90 CO-CHAPERONE CDC37-LIKE 1 protein binding#GO:0005515;binding#GO:0005488;heat shock protein binding#GO:0031072 primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;regulation of protein stability#GO:0031647;gene expression#GO:0010467;protein maturation#GO:0051604;protein folding#GO:0006457;biosynthetic process#GO:0009058;biological regulation#GO:0065007;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;regulation of biological quality#GO:0065008;protein stabilization#GO:0050821 intracellular protein-containing complex#GO:0140535;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;protein folding chaperone complex#GO:0101031 chaperone#PC00072 HUMAN|HGNC=25619|UniProtKB=Q96HE9 Q96HE9 PRR11 PTHR23330:SF9 P300 TRANSCRIPTIONAL COFACTOR JMY-RELATED PROLINE-RICH PROTEIN 11 nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=21868|UniProtKB=Q9GZY4 Q9GZY4 COA1 PTHR47148:SF1 CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1 HOMOLOG CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1 HOMOLOG cellular component assembly#GO:0022607;mitochondrion organization#GO:0007005;mitochondrial respiratory chain complex assembly#GO:0033108;mitochondrial respiratory chain complex I assembly#GO:0032981;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;respiratory chain complex IV assembly#GO:0008535;NADH dehydrogenase complex assembly#GO:0010257;mitochondrial respiratory chain complex IV assembly#GO:0033617;cytochrome complex assembly#GO:0017004 intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;membrane#GO:0016020;organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743 chaperone#PC00072 HUMAN|HGNC=8619|UniProtKB=Q02548 Q02548 PAX5 PTHR45636:SF20 PAIRED BOX PROTEIN PAX-6-RELATED-RELATED PAIRED BOX PROTEIN PAX-5 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677 regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;animal gross anatomical part developmental process#GO:0160108;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;nervous system development#GO:0007399;sensory organ development#GO:0007423;developmental process#GO:0032502;multicellular organism development#GO:0007275;animal organ development#GO:0048513;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 HUMAN|HGNC=6096|UniProtKB=A6NM10 A6NM10 AQP12B PTHR21191:SF8 AQUAPORIN AQUAPORIN-12A-RELATED transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;water channel activity#GO:0015250;water transmembrane transporter activity#GO:0005372;passive transmembrane transporter activity#GO:0022803;channel activity#GO:0015267 homeostatic process#GO:0042592;biological regulation#GO:0065007;cellular component organization#GO:0016043;regulation of cellular component size#GO:0032535;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;intracellular chemical homeostasis#GO:0055082;regulation of biological quality#GO:0065008;regulation of cell size#GO:0008361;cellular homeostasis#GO:0019725;regulation of anatomical structure size#GO:0090066;chemical homeostasis#GO:0048878 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HUMAN|HGNC=14402|UniProtKB=Q9H2X6 Q9H2X6 HIPK2 PTHR24058:SF137 DUAL SPECIFICITY PROTEIN KINASE HOMEODOMAIN-INTERACTING PROTEIN KINASE 2 catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 protein modifying enzyme#PC00260 HUMAN|HGNC=15741|UniProtKB=Q9NZH8 Q9NZH8 IL36G PTHR10078:SF37 INTERLEUKIN-1 FAMILY MEMBER INTERLEUKIN-36 GAMMA molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;cytokine activity#GO:0005125;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018 biological regulation#GO:0065007;response to other organism#GO:0051707;immune response#GO:0006955;response to external stimulus#GO:0009605;defense response#GO:0006952;cellular response to molecule of bacterial origin#GO:0071219;response to external biotic stimulus#GO:0043207;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;cellular response to biotic stimulus#GO:0071216;cell communication#GO:0007154;inflammatory response#GO:0006954;cytokine-mediated signaling pathway#GO:0019221;response to bacterium#GO:0009617;response to chemical#GO:0042221;response to cytokine#GO:0034097;cellular response to lipid#GO:0071396;response to lipid#GO:0033993;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;cellular process#GO:0009987;response to biotic stimulus#GO:0009607;cellular response to lipopolysaccharide#GO:0071222;response to stress#GO:0006950;response to lipopolysaccharide#GO:0032496;cell surface receptor signaling pathway#GO:0007166;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;response to molecule of bacterial origin#GO:0002237;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;response to peptide#GO:1901652;response to oxygen-containing compound#GO:1901700;cellular response to chemical stimulus#GO:0070887;immune system process#GO:0002376 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207;cytokine#PC00083;interleukin superfamily#PC00128 HUMAN|HGNC=186|UniProtKB=P00813 P00813 ADA PTHR11409:SF53 ADENOSINE DEAMINASE ADENOSINE DEAMINASE catalytic activity#GO:0003824;deaminase activity#GO:0019239;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;adenosine deaminase activity#GO:0004000;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity#GO:0016787 regulation of circadian rhythm#GO:0042752;carbohydrate derivative metabolic process#GO:1901135;nucleobase-containing compound catabolic process#GO:0034655;glycosyl compound catabolic process#GO:1901658;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;small molecule biosynthetic process#GO:0044283;nucleobase metabolic process#GO:0009112;leukocyte activation#GO:0045321;primary metabolic process#GO:0044238;carbohydrate derivative catabolic process#GO:1901136;catabolic process#GO:0009056;nucleoside metabolic process#GO:0009116;cell activation#GO:0001775;purine nucleoside metabolic process#GO:0042278;adenosine metabolic process#GO:0046085;cellular process#GO:0009987;regulation of multicellular organismal process#GO:0051239;lymphocyte activation#GO:0046649;purine nucleobase metabolic process#GO:0006144;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleobase-containing small molecule metabolic process#GO:0055086;purine nucleoside catabolic process#GO:0006152;purine-containing compound catabolic process#GO:0072523;carbohydrate derivative biosynthetic process#GO:1901137;regulation of biological process#GO:0050789;purine-containing compound metabolic process#GO:0072521;nucleobase-containing small molecule catabolic process#GO:0034656;T cell activation#GO:0042110;small molecule catabolic process#GO:0044282;small molecule metabolic process#GO:0044281;purine-containing compound biosynthetic process#GO:0072522;immune system process#GO:0002376;nucleoside catabolic process#GO:0009164 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 deaminase#PC00088 Adenine and hypoxanthine salvage pathway#P02723>Adenosine deaminase#P02811;Adenine and hypoxanthine salvage pathway#P02723>Deoxyadenosine deaminase#P02807 HUMAN|HGNC=19754|UniProtKB=Q96BM0 Q96BM0 IFI27L1 PTHR16932:SF36 INTERFERON ALPHA-INDUCIBLE PROTEIN 27 INTERFERON ALPHA-INDUCIBLE PROTEIN 27-LIKE PROTEIN 1 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;programmed cell death#GO:0012501;cellular response to stimulus#GO:0051716;cell death#GO:0008219;apoptotic process#GO:0006915;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;intrinsic apoptotic signaling pathway#GO:0097193;apoptotic signaling pathway#GO:0097190;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;membrane#GO:0016020;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;mitochondrial envelope#GO:0005740;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;intracellular organelle#GO:0043229 HUMAN|HGNC=18751|UniProtKB=Q8TB24 Q8TB24 RIN3 PTHR23101:SF58 RAB GDP/GTP EXCHANGE FACTOR RAS AND RAB INTERACTOR 3 nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772;protein binding#GO:0005515;small GTPase binding#GO:0031267;enzyme regulator activity#GO:0030234;guanyl-nucleotide exchange factor activity#GO:0005085;binding#GO:0005488;enzyme binding#GO:0019899 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;cytosol#GO:0005829;intracellular vesicle#GO:0097708;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endocytic vesicle#GO:0030139;intracellular organelle#GO:0043229 guanyl-nucleotide exchange factor#PC00113;protein-binding activity modulator#PC00095 HUMAN|HGNC=30927|UniProtKB=Q9NP91 Q9NP91 SLC6A20 PTHR11616:SF44 SODIUM/CHLORIDE DEPENDENT TRANSPORTER SODIUM- AND CHLORIDE-DEPENDENT TRANSPORTER XTRP3 transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;amino acid transmembrane transporter activity#GO:0015171;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;symporter activity#GO:0015293;monoatomic cation transmembrane transporter activity#GO:0008324;transmembrane transporter activity#GO:0022857;neutral L-amino acid transmembrane transporter activity#GO:0015175;L-amino acid transmembrane transporter activity#GO:0015179;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;solute:monoatomic cation symporter activity#GO:0015294;carboxylic acid transmembrane transporter activity#GO:0046943;amino acid:sodium symporter activity#GO:0005283;solute:sodium symporter activity#GO:0015370 monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;L-amino acid transport#GO:0015807;nitrogen compound transport#GO:0071705;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;establishment of localization#GO:0051234;import into cell#GO:0098657;carboxylic acid transport#GO:0046942;organic acid transport#GO:0015849;amino acid transport#GO:0006865;transport#GO:0006810;import across plasma membrane#GO:0098739;metal ion transport#GO:0030001;carboxylic acid transmembrane transport#GO:1905039;L-alpha-amino acid transmembrane transport#GO:1902475;sodium ion transport#GO:0006814;localization#GO:0051179;monoatomic cation transport#GO:0006812;neutral amino acid transport#GO:0015804;transmembrane transport#GO:0055085;amino acid transmembrane transport#GO:0003333;monoatomic ion transport#GO:0006811;glycine transport#GO:0015816 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;cell periphery#GO:0071944;apical part of cell#GO:0045177;membrane#GO:0016020;apical plasma membrane#GO:0016324 primary active transporter#PC00068 Adrenaline and noradrenaline biosynthesis#P00001>amine translocator#P00068 HUMAN|HGNC=5157|UniProtKB=P00492 P00492 HPRT1 PTHR43340:SF6 HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE magnesium ion binding#GO:0000287;cation binding#GO:0043169;metal ion binding#GO:0046872;pentosyltransferase activity#GO:0016763;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;glycosyltransferase activity#GO:0016757;transferase activity#GO:0016740;catalytic activity#GO:0003824 ribonucleotide metabolic process#GO:0009259;purine nucleotide biosynthetic process#GO:0006164;nucleoside monophosphate biosynthetic process#GO:0009124;purine-containing compound biosynthetic process#GO:0072522;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;nucleotide biosynthetic process#GO:0009165;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;small molecule metabolic process#GO:0044281;purine ribonucleoside monophosphate metabolic process#GO:0009167;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;purine nucleobase metabolic process#GO:0006144;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;purine nucleoside monophosphate metabolic process#GO:0009126;ribose phosphate biosynthetic process#GO:0046390;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;organophosphate biosynthetic process#GO:0090407;IMP biosynthetic process#GO:0006188;primary metabolic process#GO:0044238;IMP metabolic process#GO:0046040;nucleoside phosphate metabolic process#GO:0006753;nucleoside monophosphate metabolic process#GO:0009123;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase metabolic process#GO:0009112;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;carbohydrate derivative metabolic process#GO:1901135;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 metabolite interconversion enzyme#PC00262;glycosyltransferase#PC00111 Xanthine and guanine salvage pathway#P02788>Xanthine phosphoribosyl transferase#P03247;Adenine and hypoxanthine salvage pathway#P02723>Hypoxanthine phosphoribosyl transferase#P02804;Xanthine and guanine salvage pathway#P02788>Guanine phosphoribosyl transferase#P03245 HUMAN|HGNC=16028|UniProtKB=O95760 O95760 IL33 PTHR21114:SF0 DVS27 PROTEIN INTERLEUKIN-33 cytokine activity#GO:0005125;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772 positive regulation of leukocyte activation#GO:0002696;positive regulation of inflammatory response#GO:0050729;positive regulation of response to external stimulus#GO:0032103;defense response to symbiont#GO:0140546;positive regulation of biological process#GO:0048518;regulation of macrophage activation#GO:0043030;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;positive regulation of immune system process#GO:0002684;regulation of multicellular organismal process#GO:0051239;positive regulation of macromolecule metabolic process#GO:0010604;regulation of response to external stimulus#GO:0032101;defense response to other organism#GO:0098542;defense response to bacterium#GO:0042742;immune system process#GO:0002376;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of biological process#GO:0050789;regulation of cell activation#GO:0050865;positive regulation of multicellular organismal process#GO:0051240;regulation of leukocyte activation#GO:0002694;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;positive regulation of defense response#GO:0031349;regulation of response to stimulus#GO:0048583;regulation of response to stress#GO:0080134;response to external stimulus#GO:0009605;positive regulation of gene expression#GO:0010628;defense response#GO:0006952;regulation of gene expression#GO:0010468;innate immune response#GO:0045087;regulation of biosynthetic process#GO:0009889;immune response#GO:0006955;positive regulation of cellular process#GO:0048522;regulation of cytokine production#GO:0001817;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;positive regulation of cell activation#GO:0050867;response to other organism#GO:0051707;positive regulation of response to stimulus#GO:0048584;regulation of defense response#GO:0031347;regulation of inflammatory response#GO:0050727;response to bacterium#GO:0009617;positive regulation of biosynthetic process#GO:0009891;response to external biotic stimulus#GO:0043207;regulation of macromolecule metabolic process#GO:0060255;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;positive regulation of cytokine production#GO:0001819 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=16795|UniProtKB=Q6H3X3 Q6H3X3 RAET1G PTHR16675:SF232 MHC CLASS I-RELATED UL-16 BINDING PROTEIN 5 molecular function activator activity#GO:0140677;protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545 regulation of immune response#GO:0050776;regulation of immune effector process#GO:0002697;antigen processing and presentation#GO:0019882;positive regulation of lymphocyte mediated immunity#GO:0002708;regulation of leukocyte mediated cytotoxicity#GO:0001910;regulation of leukocyte mediated immunity#GO:0002703;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;response to external biotic stimulus#GO:0043207;cell killing#GO:0001906;positive regulation of leukocyte mediated immunity#GO:0002705;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;innate immune response#GO:0045087;defense response#GO:0006952;response to external stimulus#GO:0009605;positive regulation of cellular process#GO:0048522;immune response#GO:0006955;positive regulation of response to stimulus#GO:0048584;positive regulation of immune effector process#GO:0002699;response to other organism#GO:0051707;biological regulation#GO:0065007;immune system process#GO:0002376;regulation of lymphocyte mediated immunity#GO:0002706;regulation of cell killing#GO:0031341;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449;leukocyte mediated cytotoxicity#GO:0001909;regulation of biological process#GO:0050789;natural killer cell mediated immunity#GO:0002228;response to stimulus#GO:0050896;positive regulation of adaptive immune response#GO:0002821;biological process involved in interspecies interaction between organisms#GO:0044419;immune effector process#GO:0002252;natural killer cell mediated cytotoxicity#GO:0042267;response to stress#GO:0006950;positive regulation of immune system process#GO:0002684;response to biotic stimulus#GO:0009607;cellular process#GO:0009987;defense response to symbiont#GO:0140546;positive regulation of biological process#GO:0048518;defense response to other organism#GO:0098542 extracellular region#GO:0005576;external side of plasma membrane#GO:0009897;side of membrane#GO:0098552;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell surface#GO:0009986 defense/immunity protein#PC00090;major histocompatibility complex protein#PC00149 HUMAN|HGNC=19175|UniProtKB=Q8IZR5 Q8IZR5 CMTM4 PTHR22776:SF29 MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN CKLF-LIKE MARVEL TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 4 immune system process#GO:0002376;immune response#GO:0006955;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052 membrane#GO:0016020;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=20330|UniProtKB=Q9Y244 Q9Y244 POMP PTHR12828:SF3 PROTEASOME MATURATION PROTEIN UMP1 PROTEASOME MATURATION PROTEIN cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;protein-containing complex organization#GO:0043933 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 chaperone#PC00072 HUMAN|HGNC=605|UniProtKB=Q9Y235 Q9Y235 APOBEC2 PTHR13857:SF4 MRNA EDITING ENZYME C-U-EDITING ENZYME APOBEC-2 catalytic activity#GO:0003824;deaminase activity#GO:0019239;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;hydrolase activity#GO:0016787 base conversion or substitution editing#GO:0016553;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;RNA modification#GO:0009451;metabolic process#GO:0008152;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cytidine to uridine editing#GO:0016554 nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 RNA processing factor#PC00147 HUMAN|HGNC=20884|UniProtKB=Q9ULL1 Q9ULL1 PLEKHG1 PTHR45924:SF1 FI17866P1 PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 1 molecular function regulator activity#GO:0098772;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme binding#GO:0019899;binding#GO:0005488;guanyl-nucleotide exchange factor activity#GO:0005085;small GTPase binding#GO:0031267;enzyme regulator activity#GO:0030234;protein binding#GO:0005515 HUMAN|HGNC=8008|UniProtKB=Q9ULB1 Q9ULB1 NRXN1 PTHR15036:SF51 PIKACHURIN-LIKE PROTEIN NEUREXIN-1 molecular transducer activity#GO:0060089;protein binding#GO:0005515;signaling receptor activity#GO:0038023;signaling receptor binding#GO:0005102;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888 protein localization to synapse#GO:0035418;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;nervous system development#GO:0007399;cellular component assembly#GO:0022607;signal transduction#GO:0007165;postsynaptic density assembly#GO:0097107;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;nervous system process#GO:0050877;postsynaptic density organization#GO:0097106;animal gross anatomical part developmental process#GO:0160108;signaling#GO:0023052;excitatory synapse assembly#GO:1904861;response to stimulus#GO:0050896;synapse assembly#GO:0007416;regulation of biological process#GO:0050789;cell junction assembly#GO:0034329;cellular component organization#GO:0016043;intracellular protein localization#GO:0008104;system process#GO:0003008;developmental process#GO:0032502;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;macromolecule localization#GO:0033036;postsynaptic specialization organization#GO:0099084;system development#GO:0048731;localization#GO:0051179;cell communication#GO:0007154;anatomical structure development#GO:0048856;synapse organization#GO:0050808;protein localization to cell junction#GO:1902414;organelle assembly#GO:0070925;cognition#GO:0050890;postsynapse organization#GO:0099173;cell junction organization#GO:0034330;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716 presynaptic active zone#GO:0048786;cell junction#GO:0030054;synaptic membrane#GO:0097060;cellular anatomical structure#GO:0110165;synapse#GO:0045202;protein-containing complex#GO:0032991;plasma membrane region#GO:0098590;presynaptic membrane#GO:0042734;plasma membrane#GO:0005886;presynaptic active zone membrane#GO:0048787;membrane#GO:0016020;cell periphery#GO:0071944;presynapse#GO:0098793 cell adhesion molecule#PC00069 HUMAN|HGNC=23924|UniProtKB=A6NKD2 A6NKD2 TSPY2 PTHR11875:SF12 TESTIS-SPECIFIC Y-ENCODED PROTEIN TESTIS-SPECIFIC Y-ENCODED PROTEIN 1-RELATED protein binding#GO:0005515;histone binding#GO:0042393;chromatin binding#GO:0003682;binding#GO:0005488 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694;chromatin#GO:0000785;nucleus#GO:0005634 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=8723|UniProtKB=P05154 P05154 SERPINA5 PTHR11461:SF274 SERINE PROTEASE INHIBITOR, SERPIN PLASMA SERINE PROTEASE INHIBITOR peptidase regulator activity#GO:0061134;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;serine-type endopeptidase inhibitor activity#GO:0004867;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;enzyme inhibitor activity#GO:0004857;molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HUMAN|HGNC=8751|UniProtKB=Q07002 Q07002 CDK18 PTHR24056:SF52 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE 18 cyclin-dependent protein serine/threonine kinase activity#GO:0004693;cyclin-dependent protein kinase activity#GO:0097472;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096 cyclin-dependent protein kinase holoenzyme complex#GO:0000307;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554;protein kinase complex#GO:1902911;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=13356|UniProtKB=Q9GZU1 Q9GZU1 MCOLN1 PTHR12127:SF6 MUCOLIPIN MUCOLIPIN-1 transporter activity#GO:0005215;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;gated channel activity#GO:0022836;ligand-gated calcium channel activity#GO:0099604;calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;ligand-gated monoatomic cation channel activity#GO:0099094;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;monoatomic cation channel activity#GO:0005261;ligand-gated monoatomic ion channel activity#GO:0015276;channel activity#GO:0015267 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;lysosome#GO:0005764;lytic vacuole membrane#GO:0098852;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;lytic vacuole#GO:0000323;vacuolar membrane#GO:0005774;vacuole#GO:0005773;plasma membrane#GO:0005886;cytoplasm#GO:0005737;lysosomal membrane#GO:0005765;cell periphery#GO:0071944;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HUMAN|HGNC=15362|UniProtKB=Q8NGC0 Q8NGC0 OR5AU1 PTHR26452:SF186 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5AU1 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 sensory perception#GO:0007600;nervous system process#GO:0050877;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=26614|UniProtKB=Q8NB46 Q8NB46 ANKRD52 PTHR24123:SF70 ANKYRIN REPEAT-CONTAINING SERINE_THREONINE-PROTEIN PHOSPHATASE 6 REGULATORY ANKYRIN REPEAT SUBUNIT C molecular function regulator activity#GO:0098772;phosphatase regulator activity#GO:0019208;enzyme regulator activity#GO:0030234 catalytic complex#GO:1902494;protein serine/threonine phosphatase complex#GO:0008287;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=25245|UniProtKB=Q86X24 Q86X24 HORMAD1 PTHR48225:SF1 HORMA DOMAIN-CONTAINING PROTEIN 1 HORMA DOMAIN-CONTAINING PROTEIN 1 cellular process#GO:0009987;signal transduction#GO:0007165;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;homologous chromosome pairing at meiosis#GO:0007129;regulation of cell cycle process#GO:0010564;cell cycle checkpoint signaling#GO:0000075;synaptonemal complex assembly#GO:0007130;cellular component assembly#GO:0022607;chromosome segregation#GO:0007059;chromosome organization involved in meiotic cell cycle#GO:0070192;meiotic cell cycle#GO:0051321;cellular component organization or biogenesis#GO:0071840;homologous chromosome segregation#GO:0045143;negative regulation of cell cycle#GO:0045786;regulation of organelle organization#GO:0033043;cell cycle process#GO:0022402;regulation of biological process#GO:0050789;regulation of meiotic cell cycle#GO:0051445;negative regulation of cell cycle phase transition#GO:1901988;meiotic cell cycle process#GO:1903046;cellular component organization#GO:0016043;meiosis I#GO:0007127;nuclear chromosome segregation#GO:0098813;negative regulation of biological process#GO:0048519;signaling#GO:0023052;regulation of cell cycle#GO:0051726;response to stimulus#GO:0050896;regulation of cellular component organization#GO:0051128;nuclear division#GO:0000280;regulation of nuclear division#GO:0051783;negative regulation of nuclear division#GO:0051784;biological regulation#GO:0065007;regulation of reproductive process#GO:2000241;negative regulation of cell cycle process#GO:0010948;negative regulation of cellular process#GO:0048523;chromosome organization#GO:0051276;meiotic chromosome segregation#GO:0045132;meiotic nuclear division#GO:0140013;cellular response to stimulus#GO:0051716;negative regulation of organelle organization#GO:0010639;negative regulation of cellular component organization#GO:0051129;regulation of cell cycle phase transition#GO:1901987;cell cycle#GO:0007049;reproductive process#GO:0022414;regulation of cellular process#GO:0050794;sexual reproduction#GO:0019953;meiosis I cell cycle process#GO:0061982;intracellular signal transduction#GO:0035556;organelle fission#GO:0048285;cell communication#GO:0007154 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;condensed chromosome#GO:0000793;membraneless organelle#GO:0043228;condensed nuclear chromosome#GO:0000794;synaptonemal complex#GO:0000795;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;synaptonemal structure#GO:0099086;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232 HUMAN|HGNC=24077|UniProtKB=Q9UM13 Q9UM13 ANAPC10 PTHR12936:SF6 ANAPHASE-PROMOTING COMPLEX 10 ANAPHASE-PROMOTING COMPLEX SUBUNIT 10 ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740 modification-dependent macromolecule catabolic process#GO:0043632;anaphase-promoting complex-dependent catabolic process#GO:0031145;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;cell cycle#GO:0007049;modification-dependent protein catabolic process#GO:0019941;mitotic cell cycle#GO:0000278;catabolic process#GO:0009056;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;cellular process#GO:0009987;proteasomal protein catabolic process#GO:0010498 protein-containing complex#GO:0032991;anaphase-promoting complex#GO:0005680;nucleus#GO:0005634;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear ubiquitin ligase complex#GO:0000152;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ubiquitin ligase complex#GO:0000151;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 ubiquitin-protein ligase#PC00234 Cell cycle#P00013>APC#P00481 HUMAN|HGNC=2718|UniProtKB=Q92466 Q92466 DDB2 PTHR15169:SF0 DAMAGE-SPECIFIC DNA BINDING PROTEIN 2 DNA DAMAGE-BINDING PROTEIN 2 damaged DNA binding#GO:0003684;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA binding#GO:0003677 cellular response to stress#GO:0033554;cellular response to stimulus#GO:0051716;response to abiotic stimulus#GO:0009628;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;response to light stimulus#GO:0009416;response to stimulus#GO:0050896;response to UV#GO:0009411;DNA damage response#GO:0006974;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;macromolecule metabolic process#GO:0043170;response to radiation#GO:0009314;cellular process#GO:0009987;response to stress#GO:0006950;nucleobase-containing compound metabolic process#GO:0006139 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 damaged DNA-binding protein#PC00086 p53 pathway#P00059>p48#G04705 HUMAN|HGNC=29641|UniProtKB=Q2TAK8 Q2TAK8 PWWP3A PTHR31333:SF4 PWWP DOMAIN-CONTAINING DNA REPAIR FACTOR 3 FAMILY MEMBER PWWP DOMAIN-CONTAINING DNA REPAIR FACTOR 3A chromatin binding#GO:0003682;binding#GO:0005488;nucleosome binding#GO:0031491;protein-containing complex binding#GO:0044877 nucleobase-containing compound metabolic process#GO:0006139;chromatin organization#GO:0006325;cellular process#GO:0009987;response to stress#GO:0006950;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;DNA damage response#GO:0006974;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;nucleic acid metabolic process#GO:0090304;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;cellular response to stress#GO:0033554 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA metabolism protein#PC00009 HUMAN|HGNC=20275|UniProtKB=Q9NRG7 Q9NRG7 SDR39U1 PTHR11092:SF0 SUGAR NUCLEOTIDE EPIMERASE RELATED EPIMERASE FAMILY PROTEIN SDR39U1 epimerase/racemase#PC00096 HUMAN|HGNC=23716|UniProtKB=O60304 O60304 ZNF500 PTHR23226:SF74 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER PROTEIN 500 cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=11937|UniProtKB=P32970 P32970 CD70 PTHR15152:SF0 CD70 ANTIGEN CD70 ANTIGEN receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546 cell communication#GO:0007154;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immune system process#GO:0002376;cell activation#GO:0001775;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;leukocyte activation#GO:0045321;T cell activation#GO:0042110;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell surface receptor signaling pathway#GO:0007166;lymphocyte activation#GO:0046649;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;adaptive immune response#GO:0002250;immune response#GO:0006955;signal transduction#GO:0007165;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 HUMAN|HGNC=6995|UniProtKB=Q02080 Q02080 MEF2B PTHR11945:SF383 MADS BOX PROTEIN MYOCYTE-SPECIFIC ENHANCER FACTOR 2B histone deacetylase binding#GO:0042826;sequence-specific double-stranded DNA binding#GO:1990837;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulator activity#GO:0140110;enzyme binding#GO:0019899;transcription regulatory region nucleic acid binding#GO:0001067;protein binding#GO:0005515 cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;developmental process#GO:0032502;positive regulation of DNA-templated transcription#GO:0045893;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;animal organ development#GO:0048513;multicellular organism development#GO:0007275;positive regulation of transcription by RNA polymerase II#GO:0045944;heart development#GO:0007507;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;animal gross anatomical part developmental process#GO:0160108;regulation of transcription by RNA polymerase II#GO:0006357;circulatory system development#GO:0072359;cell differentiation#GO:0030154;regulation of biological process#GO:0050789 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 MADS box transcription factor#PC00250 p38 MAPK pathway#P05918>MEF#P06023;CCKR signaling map#P06959>MEF2B#P07075 HUMAN|HGNC=30287|UniProtKB=Q8N122 Q8N122 RPTOR PTHR12848:SF22 REGULATORY-ASSOCIATED PROTEIN OF MTOR REGULATORY-ASSOCIATED PROTEIN OF MTOR molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of growth#GO:0040008;response to starvation#GO:0042594;regulation of cellular process#GO:0050794;cellular response to nutrient levels#GO:0031669;cellular response to starvation#GO:0009267;regulation of catabolic process#GO:0009894;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;response to nutrient levels#GO:0031667;biological regulation#GO:0065007;cellular response to stress#GO:0033554;positive regulation of growth#GO:0045927;cellular response to chemical stimulus#GO:0070887;TORC1 signaling#GO:0038202;regulation of biological process#GO:0050789;regulation of autophagy#GO:0010506;signaling#GO:0023052;cellular response to amino acid stimulus#GO:0071230;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;positive regulation of cell growth#GO:0030307;cellular process#GO:0009987;response to acid chemical#GO:0001101;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;response to stress#GO:0006950;TOR signaling#GO:0031929;regulation of cell growth#GO:0001558;response to chemical#GO:0042221 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular protein-containing complex#GO:0140535;TOR complex#GO:0038201;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=12458|UniProtKB=P62987 P62987 UBA52 PTHR10666:SF424 UBIQUITIN UBIQUITIN-RIBOSOMAL PROTEIN EL40 FUSION PROTEIN structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 protein modification by small protein conjugation or removal#GO:0070647;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;protein modification process#GO:0036211;modification-dependent protein catabolic process#GO:0019941;protein modification by small protein conjugation#GO:0032446;catabolic process#GO:0009056;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cytosolic ribosome#GO:0022626;cytosol#GO:0005829;nucleus#GO:0005634;ribosome#GO:0005840 HUMAN|HGNC=30571|UniProtKB=Q96I27 Q96I27 ZNF625 PTHR24379:SF107 KRAB AND ZINC FINGER DOMAIN-CONTAINING ZINC FINGER PROTEIN 625 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218;C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HUMAN|HGNC=12508|UniProtKB=Q9UMX0 Q9UMX0 UBQLN1 PTHR10677:SF16 UBIQUILIN UBIQUILIN-1 polyubiquitin modification-dependent protein binding#GO:0031593;binding#GO:0005488;modification-dependent protein binding#GO:0140030;protein binding#GO:0005515 ERAD pathway#GO:0036503;vacuole organization#GO:0007033;protein metabolic process#GO:0019538;organelle assembly#GO:0070925;response to endoplasmic reticulum stress#GO:0034976;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;modification-dependent protein catabolic process#GO:0019941;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;regulation of catabolic process#GO:0009894;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;biological regulation#GO:0065007;macroautophagy#GO:0016236;regulation of metabolic process#GO:0019222;process utilizing autophagic mechanism#GO:0061919;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;modification-dependent macromolecule catabolic process#GO:0043632;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;regulation of autophagy#GO:0010506;cellular component organization#GO:0016043;regulation of macroautophagy#GO:0016241;autophagosome assembly#GO:0000045;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasomal protein catabolic process#GO:0010498;response to chemical#GO:0042221;cellular component assembly#GO:0022607;autophagy#GO:0006914;autophagosome organization#GO:1905037;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;response to stress#GO:0006950 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=32253|UniProtKB=A8MXJ8 A8MXJ8 FAM90A5 PTHR16035:SF14 PROTEIN FAM90A1 PROTEIN FAM90A10-RELATED HUMAN|HGNC=12667|UniProtKB=Q9H320 Q9H320 VCX PTHR15251:SF3 TESTIS-SPECIFIC BASIC PROTEIN Y 1-RELATED TESTIS-SPECIFIC BASIC PROTEIN Y 1-RELATED multicellular organismal process#GO:0032501;brain development#GO:0007420;central nervous system development#GO:0007417;nervous system development#GO:0007399;head development#GO:0060322;animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502;anatomical structure development#GO:0048856;animal organ development#GO:0048513;multicellular organism development#GO:0007275;system development#GO:0048731 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=18445|UniProtKB=Q96GE6 Q96GE6 CALML4 PTHR23050:SF169 CALCIUM BINDING PROTEIN CALMODULIN-LIKE PROTEIN 4 molecular function regulator activity#GO:0098772;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;calcium ion binding#GO:0005509;metal ion binding#GO:0046872;enzyme regulator activity#GO:0030234;cation binding#GO:0043169 organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226;cytoskeleton organization#GO:0007010;microtubule-based process#GO:0007017 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 calcium-binding protein#PC00060;calmodulin-related#PC00061 HUMAN|HGNC=14483|UniProtKB=Q9P0M9 Q9P0M9 MRPL27 PTHR15893:SF17 RIBOSOMAL PROTEIN L27 LARGE RIBOSOMAL SUBUNIT PROTEIN BL27M structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 metabolic process#GO:0008152;translation#GO:0006412;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;biosynthetic process#GO:0009058 intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;large ribosomal subunit#GO:0015934;membrane-bounded organelle#GO:0043227;organellar ribosome#GO:0000313;intracellular anatomical structure#GO:0005622;mitochondrial ribosome#GO:0005761;mitochondrion#GO:0005739;ribosome#GO:0005840;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrial large ribosomal subunit#GO:0005762;membraneless organelle#GO:0043228;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798 ribosomal protein#PC00202 HUMAN|HGNC=28390|UniProtKB=Q8TBF2 Q8TBF2 PRXL2B PTHR28630:SF29 FAMILY NOT NAMED PROSTAMIDE_PROSTAGLANDIN F SYNTHASE catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614 cellular process#GO:0009987;unsaturated fatty acid biosynthetic process#GO:0006636;fatty acid biosynthetic process#GO:0006633;biosynthetic process#GO:0009058;icosanoid biosynthetic process#GO:0046456;lipid biosynthetic process#GO:0008610;icosanoid metabolic process#GO:0006690;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;unsaturated fatty acid metabolic process#GO:0033559;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;monocarboxylic acid biosynthetic process#GO:0072330;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;small molecule metabolic process#GO:0044281;prostaglandin metabolic process#GO:0006693;oxoacid metabolic process#GO:0043436 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=7107|UniProtKB=P46013 P46013 MKI67 PTHR21603:SF17 ANTIGEN KI-67-LIKE PROTEIN PROLIFERATION MARKER PROTEIN KI-67 molecular condensate scaffold activity#GO:0140693;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 cell cycle#GO:0007049;regulation of biological process#GO:0050789;cell cycle process#GO:0022402;regulation of organelle organization#GO:0033043;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of cell cycle#GO:0051726;reproductive process#GO:0022414;sexual reproduction#GO:0019953;regulation of mitotic cell cycle#GO:0007346;cellular process#GO:0009987;biological regulation#GO:0065007;regulation of cell cycle process#GO:0010564;regulation of nuclear division#GO:0051783;meiotic cell cycle#GO:0051321;chromosome segregation#GO:0007059;regulation of mitotic nuclear division#GO:0007088 chromosome#GO:0005694;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;condensed chromosome#GO:0000793;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=26324|UniProtKB=Q96LR7 Q96LR7 CIMIP5 PTHR31909:SF2 CHROMOSOME 20 ORF85 FAMILY MEMBER CILIARY MICROTUBULE INNER PROTEIN 5 HUMAN|HGNC=25372|UniProtKB=Q96SY0 Q96SY0 INTS14 PTHR13532:SF3 FAMILY NOT NAMED INTEGRATOR COMPLEX SUBUNIT 14 HUMAN|HGNC=23600|UniProtKB=Q6L8G9 Q6L8G9 KRTAP5-6 PTHR23262:SF202 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 5-6 structural protein#PC00211 HUMAN|HGNC=6757|UniProtKB=Q13394 Q13394 MAB21L1 PTHR10656:SF38 CELL FATE DETERMINING PROTEIN MAB21-RELATED NUCLEOTIDYLTRANSFERASE MAB21L1-RELATED nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 transferase#PC00220;nucleotidyltransferase#PC00174 HUMAN|HGNC=26276|UniProtKB=Q7Z624 Q7Z624 CAMKMT PTHR13539:SF3 CALMODULIN-LYSINE N-METHYLTRANSFERASE CALMODULIN-LYSINE N-METHYLTRANSFERASE N-methyltransferase activity#GO:0008170;protein-lysine N-methyltransferase activity#GO:0016279;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;lysine N-methyltransferase activity#GO:0016278;protein methyltransferase activity#GO:0008276;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096 protein modifying enzyme#PC00260 HUMAN|HGNC=11386|UniProtKB=Q13586 Q13586 STIM1 PTHR15136:SF9 STROMAL INTERACTION MOLECULE HOMOLOG STROMAL INTERACTION MOLECULE 1 ion channel regulator activity#GO:0099106;calcium channel regulator activity#GO:0005246;molecular function regulator activity#GO:0098772;calcium ion binding#GO:0005509;transporter regulator activity#GO:0141108;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;cation binding#GO:0043169;channel regulator activity#GO:0016247;metal ion binding#GO:0046872 calcium ion homeostasis#GO:0055074;inorganic ion homeostasis#GO:0098771;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;intracellular monoatomic ion homeostasis#GO:0006873;metal ion transport#GO:0030001;homeostatic process#GO:0042592;transport#GO:0006810;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;establishment of localization#GO:0051234;calcium ion transport#GO:0006816;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;monoatomic ion homeostasis#GO:0050801 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;cell periphery#GO:0071944;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 HUMAN|HGNC=17854|UniProtKB=Q9HAU5 Q9HAU5 UPF2 PTHR12839:SF7 NONSENSE-MEDIATED MRNA DECAY PROTEIN 2 UP-FRAMESHIFT SUPPRESSOR 2 REGULATOR OF NONSENSE TRANSCRIPTS 2 metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;negative regulation of cellular process#GO:0048523;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay#GO:0000184;macromolecule metabolic process#GO:0043170;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;nucleobase-containing compound catabolic process#GO:0034655;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;nucleic acid catabolic process#GO:0141188;cellular process#GO:0009987;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;RNA catabolic process#GO:0006401;RNA metabolic process#GO:0016070;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;exon-exon junction complex#GO:0035145;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031 HUMAN|HGNC=4004|UniProtKB=Q96AE4 Q96AE4 FUBP1 PTHR10288:SF99 KH DOMAIN CONTAINING RNA BINDING PROTEIN FAR UPSTREAM ELEMENT-BINDING PROTEIN 1 mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA 3'-UTR binding#GO:0003730;RNA binding#GO:0003723 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031 HUMAN|HGNC=26319|UniProtKB=Q96LT6 Q96LT6 C1orf74 PTHR31366:SF2 UPF0739 PROTEIN C1ORF74 UPF0739 PROTEIN C1ORF74 HUMAN|HGNC=16200|UniProtKB=Q9H4Z3 Q9H4Z3 PCIF1 PTHR21727:SF0 PHOSPHORYLATED CTD INTERACTING FACTOR 1 MRNA (2'-O-METHYLADENOSINE-N(6)-)-METHYLTRANSFERASE nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=2366|UniProtKB=Q9UKG9 Q9UKG9 CROT PTHR22589:SF67 CARNITINE O-ACYLTRANSFERASE PEROXISOMAL CARNITINE O-OCTANOYLTRANSFERASE acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;peroxisome#GO:0005777;microbody#GO:0042579;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 metabolite interconversion enzyme#PC00262;acyltransferase#PC00042 HUMAN|HGNC=26930|UniProtKB=A0A1W2PR19 A0A1W2PR19 GSTT4 PTHR43917:SF13 FAMILY NOT NAMED GLUTATHIONE S-TRANSFERASE THETA-4 glutathione transferase activity#GO:0004364;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765 metabolic process#GO:0008152;sulfur compound metabolic process#GO:0006790;glutathione metabolic process#GO:0006749;modified amino acid metabolic process#GO:0006575;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 transferase#PC00220 HUMAN|HGNC=3274|UniProtKB=O75821 O75821 EIF3G PTHR10352:SF88 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;biosynthetic process#GO:0009058;metabolic process#GO:0008152;translation#GO:0006412;translational initiation#GO:0006413;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 eukaryotic translation initiation factor 3 complex#GO:0005852;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 HUMAN|HGNC=32302|UniProtKB=P63133 P63133 ERVK-8 PTHR41694:SF3 ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN ENDOGENOUS RETROVIRUS GROUP K MEMBER 10 POL PROTEIN-RELATED binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 viral or transposable element protein#PC00237 HUMAN|HGNC=9216|UniProtKB=P20264 P20264 POU3F3 PTHR11636:SF125 POU DOMAIN POU DOMAIN, CLASS 3, TRANSCRIPTION FACTOR 3 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=20289|UniProtKB=Q8N752 Q8N752 CSNK1A1L PTHR11909:SF139 CASEIN KINASE-RELATED CASEIN KINASE I ISOFORM ALPHA-LIKE protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096 regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of canonical Wnt signaling pathway#GO:0060828;negative regulation of signal transduction#GO:0009968;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of response to stimulus#GO:0048585;negative regulation of Wnt signaling pathway#GO:0030178;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;negative regulation of canonical Wnt signaling pathway#GO:0090090;negative regulation of cell communication#GO:0010648;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of Wnt signaling pathway#GO:0030111;regulation of cell communication#GO:0010646;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 non-receptor serine/threonine protein kinase#PC00167 Wnt signaling pathway#P00057>Casein Kinase 1#P01460;Parkinson disease#P00049>Casein kinase I#P01242;Hedgehog signaling pathway#P00025>Casein kinase I#P00681 HUMAN|HGNC=13916|UniProtKB=O95445 O95445 APOM PTHR32028:SF1 APOLIPOPROTEIN M APOLIPOPROTEIN M molecular carrier activity#GO:0140104;lipid carrier activity#GO:0005319;phospholipid binding#GO:0005543;binding#GO:0005488;lipid binding#GO:0008289 cellular component organization or biogenesis#GO:0071840;sterol transport#GO:0015918;plasma lipoprotein particle clearance#GO:0034381;establishment of localization#GO:0051234;protein-containing complex organization#GO:0043933;transport#GO:0006810;cellular component assembly#GO:0022607;lipid transport#GO:0006869;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;cellular component biogenesis#GO:0044085;macromolecule localization#GO:0033036;cholesterol transport#GO:0030301;cellular process#GO:0009987;cholesterol efflux#GO:0033344;localization#GO:0051179;organic hydroxy compound transport#GO:0015850;lipid localization#GO:0010876;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;protein-containing complex assembly#GO:0065003 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;very-low-density lipoprotein particle#GO:0034361;plasma lipoprotein particle#GO:0034358;high-density lipoprotein particle#GO:0034364;extracellular region#GO:0005576;protein-lipid complex#GO:0032994;extracellular protein-containing complex#GO:0140392;lipoprotein particle#GO:1990777 transfer/carrier protein#PC00219;apolipoprotein#PC00052 HUMAN|HGNC=18060|UniProtKB=Q96QS3 Q96QS3 ARX PTHR24329:SF583 HOMEOBOX PROTEIN ARISTALESS HOMEOBOX PROTEIN ARX sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 cellular process#GO:0009987;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;nervous system development#GO:0007399;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;neuron differentiation#GO:0030182;developmental process#GO:0032502;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;multicellular organism development#GO:0007275;regulation of biological process#GO:0050789;cell development#GO:0048468;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;neuron development#GO:0048666;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 gene-specific transcriptional regulator#PC00264;homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=17866|UniProtKB=Q96D42 Q96D42 HAVCR1 PTHR47009:SF1 HEPATITIS A VIRUS CELLULAR RECEPTOR 1 HOMOLOG HEPATITIS A VIRUS CELLULAR RECEPTOR 1 ion binding#GO:0043167;binding#GO:0005488;anion binding#GO:0043168;small molecule binding#GO:0036094;phosphatidylserine binding#GO:0001786;protein binding#GO:0005515;lipid binding#GO:0008289;phospholipid binding#GO:0005543;virus receptor activity#GO:0001618 localization#GO:0051179;endocytosis#GO:0006897;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of biological process#GO:0050789;regulation of cell activation#GO:0050865;positive regulation of multicellular organismal process#GO:0051240;regulation of leukocyte activation#GO:0002694;cellular component organization#GO:0016043;phagocytosis, engulfment#GO:0006911;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;import into cell#GO:0098657;membrane invagination#GO:0010324;transport#GO:0006810;positive regulation of leukocyte activation#GO:0002696;phagocytosis#GO:0006909;biological regulation#GO:0065007;membrane organization#GO:0061024;positive regulation of cell activation#GO:0050867;regulation of multicellular organismal process#GO:0051239;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;positive regulation of immune system process#GO:0002684 cell surface#GO:0009986;cellular anatomical structure#GO:0110165 HUMAN|HGNC=11363|UniProtKB=P52630 P52630 STAT2 PTHR11801:SF41 SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 2 nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 response to stress#GO:0006950;response to hormone#GO:0009725;response to biotic stimulus#GO:0009607;cellular process#GO:0009987;signal transduction#GO:0007165;defense response to symbiont#GO:0140546;defense response to other organism#GO:0098542;response to cytokine#GO:0034097;response to chemical#GO:0042221;cell surface receptor signaling pathway via STAT#GO:0097696;cell surface receptor signaling pathway#GO:0007166;response to endogenous stimulus#GO:0009719;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052;type I interferon-mediated signaling pathway#GO:0060337;immune system process#GO:0002376;response to oxygen-containing compound#GO:1901700;response to peptide#GO:1901652;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;immune response#GO:0006955;regulation of nucleobase-containing compound metabolic process#GO:0019219;response to other organism#GO:0051707;response to peptide hormone#GO:0043434;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;cell surface receptor signaling pathway via JAK-STAT#GO:0007259;regulation of biosynthetic process#GO:0009889;innate immune response#GO:0045087;regulation of gene expression#GO:0010468;defense response#GO:0006952;response to external stimulus#GO:0009605;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;response to external biotic stimulus#GO:0043207;cytokine-mediated signaling pathway#GO:0019221;regulation of DNA-templated transcription#GO:0006355;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;regulation of RNA metabolic process#GO:0051252;response to nitrogen compound#GO:1901698 intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 Rel homology transcription factor#PC00252;immunoglobulin fold transcription factor#PC00251 JAK/STAT signaling pathway#P00038>STAT#P01027;EGF receptor signaling pathway#P00018>STAT#P00561;PDGF signaling pathway#P00047>STAT#P01173;Interleukin signaling pathway#P00036>STAT#P00996 HUMAN|HGNC=14469|UniProtKB=Q7LBE3 Q7LBE3 SLC26A9 PTHR11814:SF17 SULFATE TRANSPORTER SOLUTE CARRIER FAMILY 26 MEMBER 9 carboxylic acid transmembrane transporter activity#GO:0046943;monoatomic anion transmembrane transporter activity#GO:0008509;secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;bicarbonate transmembrane transporter activity#GO:0015106;antiporter activity#GO:0015297;chloride transmembrane transporter activity#GO:0015108;active transmembrane transporter activity#GO:0022804;monoatomic ion transmembrane transporter activity#GO:0015075;dicarboxylic acid transmembrane transporter activity#GO:0005310 chloride transmembrane transport#GO:1902476;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;inorganic anion transport#GO:0015698;monoatomic ion transport#GO:0006811;chloride transport#GO:0006821;transport#GO:0006810;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220;monoatomic anion transport#GO:0006820;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227 HUMAN|HGNC=5291|UniProtKB=P28566 P28566 HTR1E PTHR24247:SF33 5-HYDROXYTRYPTAMINE RECEPTOR 5-HYDROXYTRYPTAMINE RECEPTOR 1E transmembrane signaling receptor activity#GO:0004888;G protein-coupled amine receptor activity#GO:0008227;neurotransmitter receptor activity#GO:0030594;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930 cell-cell signaling#GO:0007267;biological regulation#GO:0065007;signal transduction#GO:0007165;cellular process#GO:0009987;synaptic signaling#GO:0099536;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway#GO:0007193;signaling#GO:0023052;anterograde trans-synaptic signaling#GO:0098916;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;chemical synaptic transmission#GO:0007268;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;trans-synaptic signaling#GO:0099537 membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005;cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;cell projection#GO:0042995;somatodendritic compartment#GO:0036477;dendrite#GO:0030425;dendritic tree#GO:0097447 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GsPCR#P00720;5HT1 type receptor mediated signaling pathway#P04373>5HT1 Receptor#P04404;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711 HUMAN|HGNC=16408|UniProtKB=Q8NFV5 Q8NFV5 SPDYE1 PTHR31156:SF26 WBSCR19-LIKE PROTEIN SPEEDY PROTEIN E1 HUMAN|HGNC=5585|UniProtKB=A0A0C4DH32 A0A0C4DH32 IGHV3-20 PTHR23266:SF338 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 3-20 antigen binding#GO:0003823;binding#GO:0005488 immune system process#GO:0002376;immune effector process#GO:0002252;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449;immunoglobulin mediated immune response#GO:0016064;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immune response#GO:0006955;response to stimulus#GO:0050896;adaptive immune response#GO:0002250 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=14296|UniProtKB=Q8N339 Q8N339 MT1M PTHR23299:SF24 METALLOTHIONEIN METALLOTHIONEIN-1E-RELATED defense/immunity protein#PC00090 HUMAN|HGNC=18501|UniProtKB=Q8TD47 Q8TD47 RPS4Y2 PTHR11581:SF7 30S/40S RIBOSOMAL PROTEIN S4 SMALL RIBOSOMAL SUBUNIT PROTEIN ES4, Y ISOFORM 2 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 biosynthetic process#GO:0009058;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;translation#GO:0006412;metabolic process#GO:0008152 intracellular organelle#GO:0043229;small ribosomal subunit#GO:0015935;ribonucleoprotein complex#GO:1990904;cytosolic small ribosomal subunit#GO:0022627;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;ribosome#GO:0005840;cytosol#GO:0005829;cytosolic ribosome#GO:0022626;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 ribosomal protein#PC00202 HUMAN|HGNC=24464|UniProtKB=Q8NCH0 Q8NCH0 CHST14 PTHR12137:SF66 CARBOHYDRATE SULFOTRANSFERASE CARBOHYDRATE SULFOTRANSFERASE 14 transferase activity#GO:0016740;catalytic activity#GO:0003824;sulfotransferase activity#GO:0008146;transferase activity, transferring sulphur-containing groups#GO:0016782 metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;proteoglycan metabolic process#GO:0006029;primary metabolic process#GO:0044238;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135 transferase#PC00220 HUMAN|Ensembl=ENSG00000285154.1|UniProtKB=A0A2R8YEH3 A0A2R8YEH3 LOC112268384 PTHR26453:SF115 OLFACTORY RECEPTOR OLFACTORY RECEPTOR-RELATED transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 system process#GO:0003008;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;nervous system process#GO:0050877;sensory perception#GO:0007600;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;response to stimulus#GO:0050896;response to chemical#GO:0042221;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;detection of chemical stimulus#GO:0009593 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=28796|UniProtKB=Q96HT8 Q96HT8 MRFAP1L1 PTHR31324:SF2 MORF4 FAMILY-ASSOCIATED PROTEIN 1-RELATED MORF4 FAMILY-ASSOCIATED PROTEIN 1-LIKE 1 HUMAN|HGNC=11026|UniProtKB=P08195 P08195 SLC3A2 PTHR46673:SF1 4F2 CELL-SURFACE ANTIGEN HEAVY CHAIN AMINO ACID TRANSPORTER HEAVY CHAIN SLC3A2 import across plasma membrane#GO:0098739;carboxylic acid transmembrane transport#GO:1905039;L-leucine transport#GO:0015820;L-alpha-amino acid transmembrane transport#GO:1902475;amino acid transmembrane transport#GO:0003333;neutral amino acid transport#GO:0015804;transmembrane transport#GO:0055085;localization#GO:0051179;nitrogen compound transport#GO:0071705;L-amino acid transport#GO:0015807;cellular process#GO:0009987;establishment of localization#GO:0051234;import into cell#GO:0098657;branched-chain amino acid transport#GO:0015803;carboxylic acid transport#GO:0046942;amino acid transport#GO:0006865;transport#GO:0006810;organic acid transport#GO:0015849;alanine transport#GO:0032328 apical part of cell#GO:0045177;membrane#GO:0016020;apical plasma membrane#GO:0016324;basal part of cell#GO:0045178;basolateral plasma membrane#GO:0016323;cell periphery#GO:0071944;basal plasma membrane#GO:0009925;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;plasma membrane#GO:0005886 HUMAN|HGNC=3343|UniProtKB=P19622 P19622 EN2 PTHR24341:SF5 HOMEOBOX PROTEIN ENGRAILED HOMEOBOX PROTEIN ENGRAILED-2 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;multicellular organism development#GO:0007275;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;neuron differentiation#GO:0030182;developmental process#GO:0032502;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;nervous system development#GO:0007399;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 Wnt signaling pathway#P00057>Wnt Target Genes#G01558 HUMAN|HGNC=25402|UniProtKB=Q96G74 Q96G74 OTUD5 PTHR12419:SF122 OTU DOMAIN CONTAINING PROTEIN OTU DOMAIN-CONTAINING PROTEIN 5 deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;cysteine-type deubiquitinase activity#GO:0004843;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783 regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;negative regulation of canonical Wnt signaling pathway#GO:0090090;regulation of signaling#GO:0023051;regulation of immune response#GO:0050776;positive regulation of signaling#GO:0023056;negative regulation of cell communication#GO:0010648;positive regulation of TOR signaling#GO:0032008;positive regulation of signal transduction#GO:0009967;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;regulation of TORC1 signaling#GO:1903432;regulation of canonical Wnt signaling pathway#GO:0060828;positive regulation of TORC1 signaling#GO:1904263;regulation of TOR signaling#GO:0032006;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;negative regulation of Wnt signaling pathway#GO:0030178;negative regulation of response to stimulus#GO:0048585;positive regulation of response to stimulus#GO:0048584;negative regulation of signal transduction#GO:0009968;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966 cysteine protease#PC00081 HUMAN|HGNC=28518|UniProtKB=Q6UXV1 Q6UXV1 IZUMO2 PTHR47745:SF1 IZUMO SPERM-EGG FUSION PROTEIN 2 IZUMO SPERM-EGG FUSION PROTEIN 2 HUMAN|HGNC=28224|UniProtKB=Q9BRU9 Q9BRU9 UTP23 PTHR12416:SF3 RRNA-PROCESSING PROTEIN UTP23 HOMOLOG RRNA-PROCESSING PROTEIN UTP23 HOMOLOG rRNA binding#GO:0019843;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 gene expression#GO:0010467;biosynthetic process#GO:0009058;maturation of SSU-rRNA#GO:0030490;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;cellular component biogenesis#GO:0044085;endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000479;endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000480;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;ribosomal small subunit biogenesis#GO:0042274;RNA biosynthetic process#GO:0032774;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;ribonucleoprotein complex biogenesis#GO:0022613;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187 organelle lumen#GO:0043233;small-subunit processome#GO:0032040;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;preribosome#GO:0030684;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228 HUMAN|HGNC=2206|UniProtKB=P53420 P53420 COL4A4 PTHR24023:SF714 COLLAGEN ALPHA COLLAGEN ALPHA-4(IV) CHAIN structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 cellular component organization#GO:0016043;extracellular structure organization#GO:0043062;cellular process#GO:0009987;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;external encapsulating structure organization#GO:0045229 external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;basement membrane#GO:0005604;supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;extracellular protein-containing complex#GO:0140392;extracellular region#GO:0005576 extracellular matrix structural protein#PC00103;extracellular matrix protein#PC00102 Integrin signalling pathway#P00034>Collagen#P00922 HUMAN|HGNC=10351|UniProtKB=Q92901 Q92901 RPL3L PTHR11363:SF7 60S RIBOSOMAL PROTEIN L3-RELATED RIBOSOMAL PROTEIN UL3-LIKE structural molecule activity#GO:0005198;RNA binding#GO:0003723;structural constituent of ribosome#GO:0003735;binding#GO:0005488;nucleic acid binding#GO:0003676 primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058;metabolic process#GO:0008152;translation#GO:0006412;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;ribosome#GO:0005840;cytosol#GO:0005829;cytosolic large ribosomal subunit#GO:0022625;cytosolic ribosome#GO:0022626;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 ribosomal protein#PC00202;translational protein#PC00263 HUMAN|HGNC=29853|UniProtKB=Q9P2P5 Q9P2P5 HECW2 PTHR11254:SF127 HECT DOMAIN UBIQUITIN-PROTEIN LIGASE E3 UBIQUITIN-PROTEIN LIGASE HECW2 ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 regulation of developmental process#GO:0050793;catabolic process#GO:0009056;regulation of cellular component organization#GO:0051128;regulation of dendrite development#GO:0050773;regulation of cellular process#GO:0050794;modification-dependent protein catabolic process#GO:0019941;regulation of biological process#GO:0050789;primary metabolic process#GO:0044238;regulation of dendrite morphogenesis#GO:0048814;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;biological regulation#GO:0065007;regulation of neuron projection development#GO:0010975;cellular process#GO:0009987;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of anatomical structure morphogenesis#GO:0022603;regulation of cell projection organization#GO:0031344;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=25906|UniProtKB=Q8NCF5 Q8NCF5 NFATC2IP PTHR47187:SF1 NFATC2-INTERACTING PROTEIN NFATC2-INTERACTING PROTEIN positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of transcription by RNA polymerase II#GO:0045944 HUMAN|HGNC=21205|UniProtKB=Q96FE5 Q96FE5 LINGO1 PTHR24373:SF31 SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN LEUCINE-RICH REPEAT AND IMMUNOGLOBULIN-LIKE DOMAIN-CONTAINING NOGO RECEPTOR-INTERACTING PROTEIN 1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=28477|UniProtKB=Q8NBM8 Q8NBM8 PCYOX1L PTHR15944:SF2 FARNESYLCYSTEINE LYASE PRENYLCYSTEINE OXIDASE 1-LIKE oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056 metabolite interconversion enzyme#PC00262;lyase#PC00144 HUMAN|HGNC=29280|UniProtKB=Q9P278 Q9P278 FNIP2 PTHR21634:SF11 RE13835P FOLLICULIN-INTERACTING PROTEIN 2 protein-folding chaperone binding#GO:0051087;binding#GO:0005488;molecular function inhibitor activity#GO:0140678;molecular function regulator activity#GO:0098772;protein binding#GO:0005515 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=18510|UniProtKB=Q5T6X5 Q5T6X5 GPRC6A PTHR24061:SF5 CALCIUM-SENSING RECEPTOR-RELATED G PROTEIN-COUPLED RECEPTOR FAMILY C GROUP 6 MEMBER A signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=8660|UniProtKB=O95206 O95206 PCDH8 PTHR24028:SF46 CADHERIN-87A PROTOCADHERIN-8 cell-cell adhesion#GO:0098609;cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;synapse#GO:0045202;cell junction#GO:0030054 cadherin#PC00057;cell adhesion molecule#PC00069 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HUMAN|HGNC=8960|UniProtKB=Q92535 Q92535 PIGC PTHR12982:SF1 PHOSPHATIDYLINOSITOL GLYCAN, CLASS C PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT C glycerolipid metabolic process#GO:0046486;liposaccharide metabolic process#GO:1903509;GPI anchored protein biosynthesis#GO:0180046;phospholipid biosynthetic process#GO:0008654;glycolipid metabolic process#GO:0006664;phospholipid metabolic process#GO:0006644;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;glycolipid biosynthetic process#GO:0009247;organophosphate biosynthetic process#GO:0090407;protein metabolic process#GO:0019538;GPI anchor biosynthetic process#GO:0006506;glycerophospholipid metabolic process#GO:0006650;protein maturation#GO:0051604;gene expression#GO:0010467;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058;organophosphate metabolic process#GO:0019637;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;metabolic process#GO:0008152;glycerophospholipid biosynthetic process#GO:0046474;GPI anchor metabolic process#GO:0006505;lipid metabolic process#GO:0006629 endoplasmic reticulum membrane#GO:0005789;transferase complex#GO:1990234;endoplasmic reticulum#GO:0005783;endoplasmic reticulum protein-containing complex#GO:0140534;organelle membrane#GO:0031090;membrane#GO:0016020;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane protein complex#GO:0098796;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 glycosyltransferase#PC00111 HUMAN|HGNC=26672|UniProtKB=Q6ZUB1 Q6ZUB1 SPATA31E1 PTHR21859:SF58 ACROSOME-SPECIFIC PROTEIN SPERMATOGENESIS-ASSOCIATED PROTEIN 31E1 HUMAN|HGNC=4277|UniProtKB=Q9Y6H8 Q9Y6H8 GJA3 PTHR11984:SF12 CONNEXIN GAP JUNCTION ALPHA-3 PROTEIN transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;channel activity#GO:0015267;wide pore channel activity#GO:0022829 signaling#GO:0023052;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789 cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane#GO:0016020;cell-cell junction#GO:0005911;membrane protein complex#GO:0098796;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;anchoring junction#GO:0070161;cell junction#GO:0030054 gap junction#PC00105;cell junction protein#PC00070 HUMAN|HGNC=44410|UniProtKB=H3BQL2 H3BQL2 GOLGA8T PTHR10881:SF62 GOLGIN SUBFAMILY A MEMBER-RELATED GOLGIN SUBFAMILY A CONSERVED DOMAIN-CONTAINING PROTEIN-RELATED cellular component organization or biogenesis#GO:0071840;endomembrane system organization#GO:0010256;organelle organization#GO:0006996;cellular component organization#GO:0016043;Golgi organization#GO:0007030;cellular process#GO:0009987 organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;Golgi stack#GO:0005795;cis-Golgi network#GO:0005801;organelle membrane#GO:0031090;Golgi apparatus#GO:0005794;Golgi cisterna#GO:0031985;endomembrane system#GO:0012505;Golgi cis cisterna#GO:0000137;cytoplasm#GO:0005737;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020 membrane traffic protein#PC00150 HUMAN|HGNC=24523|UniProtKB=Q8IYH5 Q8IYH5 ZZZ3 PTHR22705:SF0 ZINC FINGER, ZZ DOMAIN CONTAINING 3 ZZ-TYPE ZINC FINGER-CONTAINING PROTEIN 3 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=5622|UniProtKB=A0A0B4J1Y9 A0A0B4J1Y9 IGHV3-72 PTHR23266:SF369 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 3-72 antigen binding#GO:0003823;binding#GO:0005488 adaptive immune response#GO:0002250;response to stimulus#GO:0050896;immune response#GO:0006955;immunoglobulin mediated immune response#GO:0016064;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449;immune effector process#GO:0002252;immune system process#GO:0002376 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=7594|UniProtKB=Q9UKN7 Q9UKN7 MYO15A PTHR13140:SF709 MYOSIN UNCONVENTIONAL MYOSIN-XV cytoskeletal motor activity#GO:0003774;isomerase activity#GO:0016853;microfilament motor activity#GO:0000146;catalytic activity#GO:0003824;polypeptide conformation or assembly isomerase activity#GO:0120544;ATP-dependent activity#GO:0140657;macromolecular conformation isomerase activity#GO:0120543 cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;actin cytoskeleton organization#GO:0030036;cytoskeleton organization#GO:0007010;actin filament-based process#GO:0030029;cellular component organization or biogenesis#GO:0071840;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;actin cytoskeleton#GO:0015629;membrane#GO:0016020;actin-based cell projection#GO:0098858 actin binding motor protein#PC00040 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HUMAN|HGNC=8499|UniProtKB=P19652 P19652 ORM2 PTHR11967:SF3 ALPHA-1-ACID GLYCOPROTEIN ALPHA-1-ACID GLYCOPROTEIN 2 acute inflammatory response#GO:0002526;defense response#GO:0006952;response to stimulus#GO:0050896;immune response#GO:0006955;inflammatory response#GO:0006954;immune system process#GO:0002376;response to stress#GO:0006950 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=11713|UniProtKB=Q9Y2W6 Q9Y2W6 TDRKH PTHR22948:SF18 TUDOR DOMAIN CONTAINING PROTEIN TUDOR AND KH DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HUMAN|HGNC=4499|UniProtKB=O14843 O14843 FFAR3 PTHR45822:SF6 FREE FATTY ACID RECEPTOR 2-RELATED FREE FATTY ACID RECEPTOR 3-RELATED transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;cellular response to fatty acid#GO:0071398;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cell communication#GO:0007154;response to fatty acid#GO:0070542;G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887;response to oxygen-containing compound#GO:1901700;response to lipid#GO:0033993;cellular response to lipid#GO:0071396;response to chemical#GO:0042221;biological regulation#GO:0065007;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 HUMAN|HGNC=15131|UniProtKB=Q9H207 Q9H207 OR10A5 PTHR26453:SF148 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 10A5 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;response to chemical#GO:0042221;response to stimulus#GO:0050896;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;detection of chemical stimulus#GO:0009593;system process#GO:0003008;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;nervous system process#GO:0050877;sensory perception#GO:0007600 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=10484|UniProtKB=Q92736 Q92736 RYR2 PTHR46399:SF7 B30.2/SPRY DOMAIN-CONTAINING PROTEIN RYANODINE RECEPTOR 2 channel activity#GO:0015267;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation channel activity#GO:0005261;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;monoatomic cation transmembrane transporter activity#GO:0008324;ligand-gated calcium channel activity#GO:0099604;calcium ion transmembrane transporter activity#GO:0015085;gated channel activity#GO:0022836;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;transporter activity#GO:0005215 establishment of localization#GO:0051234;calcium ion transmembrane import into cytosol#GO:0097553;calcium ion transport#GO:0006816;system process#GO:0003008;transport#GO:0006810;muscle contraction#GO:0006936;multicellular organismal process#GO:0032501;monoatomic ion transmembrane transport#GO:0034220;release of sequestered calcium ion into cytosol by sarcoplasmic reticulum#GO:0014808;monoatomic cation transmembrane transport#GO:0098655;release of sequestered calcium ion into cytosol#GO:0051209;cellular process#GO:0009987;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;striated muscle contraction#GO:0006941;metal ion transport#GO:0030001;calcium ion transmembrane transport#GO:0070588;muscle system process#GO:0003012 nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;calcium channel complex#GO:0034704;myofibril#GO:0030016;supramolecular fiber#GO:0099512;organelle subcompartment#GO:0031984;intracellular organelle#GO:0043229;supramolecular complex#GO:0099080;sarcoplasmic reticulum membrane#GO:0033017;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;sarcoplasmic reticulum#GO:0016529;contractile muscle fiber#GO:0043292;sarcomere#GO:0030017;transporter complex#GO:1990351;bounding membrane of organelle#GO:0098588;cation channel complex#GO:0034703;endoplasmic reticulum#GO:0005783;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;transmembrane transporter complex#GO:1902495;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;sarcoplasm#GO:0016528;endoplasmic reticulum subcompartment#GO:0098827;endomembrane system#GO:0012505;monoatomic ion channel complex#GO:0034702;plasma membrane#GO:0005886;membrane#GO:0016020;Z disc#GO:0030018;cell periphery#GO:0071944;sarcolemma#GO:0042383;membraneless organelle#GO:0043228;organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;I band#GO:0031674 CCKR signaling map#P06959>RYR1/2/3#P07088;Beta1 adrenergic receptor signaling pathway#P04377>ER-type Ca2+ channel#P04434;Beta2 adrenergic receptor signaling pathway#P04378>ER-type Ca2+ channel#P04441 HUMAN|HGNC=19011|UniProtKB=Q8IZF3 Q8IZF3 ADGRF4 PTHR45813:SF1 IG-LIKE DOMAIN-CONTAINING PROTEIN ADHESION G PROTEIN-COUPLED RECEPTOR F4 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021 HUMAN|HGNC=25024|UniProtKB=Q9HBI5 Q9HBI5 CEP15 PTHR14286:SF2 GENE, 49355-RELATED CENTROSOMAL PROTEIN 15 HUMAN|HGNC=15625|UniProtKB=A2RRP1 A2RRP1 NBAS PTHR15922:SF2 NEUROBLASTOMA-AMPLIFIED SEQUENCE NBAS SUBUNIT OF NRZ TETHERING COMPLEX binding#GO:0005488;SNARE binding#GO:0000149;protein binding#GO:0005515 Golgi vesicle transport#GO:0048193;transport#GO:0006810;cellular process#GO:0009987;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;localization#GO:0051179 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;vesicle tethering complex#GO:0099023;membrane-bounded organelle#GO:0043227;endoplasmic reticulum protein-containing complex#GO:0140534;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 HUMAN|HGNC=30035|UniProtKB=Q8WYR1 Q8WYR1 PIK3R5 PTHR15593:SF2 PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5 kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234 positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;signaling#GO:0023052;regulation of cell communication#GO:0010646;response to stimulus#GO:0050896;positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051897;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of signaling#GO:0023051;G protein-coupled receptor signaling pathway#GO:0007186;regulation of intracellular signal transduction#GO:1902531;regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051896;cell communication#GO:0007154;positive regulation of signaling#GO:0023056 catalytic complex#GO:1902494;transferase complex#GO:1990234;transferase complex, transferring phosphorus-containing groups#GO:0061695;extrinsic component of membrane#GO:0019898;membrane protein complex#GO:0098796;membrane#GO:0016020;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 kinase modulator#PC00140;protein-binding activity modulator#PC00095 Endothelin signaling pathway#P00019>PI3K#P00577;p53 pathway#P00059>PI3K#P04609;EGF receptor signaling pathway#P00018>PI3K#P00557;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>PI3K#P00900;PDGF signaling pathway#P00047>PI3K#P01168;p53 pathway feedback loops 2#P04398>PI3K#P04661;PI3 kinase pathway#P00048>p101#P01203;Axon guidance mediated by netrin#P00009>PI3K#P00363 HUMAN|HGNC=34548|UniProtKB=A6NDP7 A6NDP7 MYADML2 PTHR17068:SF5 MYELOID-ASSOCIATED DIFFERENTIATION MARKER MYADM FAMILY MEMBER MYELOID-ASSOCIATED DIFFERENTIATION MARKER-LIKE PROTEIN 2 HUMAN|HGNC=12706|UniProtKB=O95498 O95498 VNN2 PTHR10609:SF15 BIOTINIDASE-RELATED PANTETHEINE HYDROLASE VNN2 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810 small molecule metabolic process#GO:0044281;cellular process#GO:0009987;modified amino acid metabolic process#GO:0006575;carboxylic acid metabolic process#GO:0019752;oxoacid metabolic process#GO:0043436;monocarboxylic acid metabolic process#GO:0032787;metabolic process#GO:0008152 hydrolase#PC00121 HUMAN|HGNC=18674|UniProtKB=Q9UJV9 Q9UJV9 DDX41 PTHR47958:SF103 ATP-DEPENDENT RNA HELICASE DBP3 ATP-DEPENDENT RNA HELICASE DDX41-RELATED helicase activity#GO:0004386;isomerase activity#GO:0016853;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;RNA helicase activity#GO:0003724;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543;RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;ATP-dependent activity#GO:0140657 RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;mRNA splicing, via spliceosome#GO:0000398;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397 nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;spliceosomal complex#GO:0005681;nucleus#GO:0005634 RNA helicase#PC00032 HUMAN|HGNC=2640|UniProtKB=P24462 P24462 CYP3A7 PTHR24302:SF31 CYTOCHROME P450 FAMILY 3 CYTOCHROME P450 3A7 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen#GO:0016712;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;monooxygenase activity#GO:0004497;steroid hydroxylase activity#GO:0008395;catalytic activity#GO:0003824 steroid metabolic process#GO:0008202;metabolic process#GO:0008152;primary metabolic process#GO:0044238;lipid metabolic process#GO:0006629;cellular process#GO:0009987 oxidoreductase#PC00176;oxygenase#PC00177 HUMAN|HGNC=20043|UniProtKB=Q8TEQ6 Q8TEQ6 GEMIN5 PTHR46362:SF1 GEM-ASSOCIATED PROTEIN 5 GEM-ASSOCIATED PROTEIN 5 RNA binding#GO:0003723;mRNA 3'-UTR binding#GO:0003730;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488 RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;ribonucleoprotein complex biogenesis#GO:0022613;spliceosomal snRNP assembly#GO:0000387;protein-containing complex assembly#GO:0065003;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;nucleic acid metabolic process#GO:0090304;protein-RNA complex assembly#GO:0022618;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;cellular component assembly#GO:0022607;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;mRNA processing#GO:0006397;protein-containing complex organization#GO:0043933;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;protein-RNA complex organization#GO:0071826;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;SMN-Sm protein complex#GO:0034719;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;SMN complex#GO:0032797;Sm-like protein family complex#GO:0120114;intracellular organelle#GO:0043229 HUMAN|HGNC=20390|UniProtKB=Q9Y6N5 Q9Y6N5 SQOR PTHR10632:SF2 SULFIDE:QUINONE OXIDOREDUCTASE SULFIDE:QUINONE OXIDOREDUCTASE, MITOCHONDRIAL small molecule binding#GO:0036094;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;flavin adenine dinucleotide binding#GO:0050660;anion binding#GO:0043168;binding#GO:0005488;nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167;nucleotide binding#GO:0000166;oxidoreductase activity#GO:0016491;heterocyclic compound binding#GO:1901363;catalytic activity#GO:0003824 cellular process#GO:0009987;metabolic process#GO:0008152;sulfur compound metabolic process#GO:0006790 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 oxidoreductase#PC00176 HUMAN|HGNC=32946|UniProtKB=Q5JPF3 Q5JPF3 ANKRD36C PTHR24147:SF71 ANKYRIN REPEAT DOMAIN 36-RELATED ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 36C HUMAN|HGNC=25543|UniProtKB=Q6PI26 Q6PI26 SHQ1 PTHR12967:SF0 PROTEIN SHQ1 HOMOLOG PROTEIN SHQ1 HOMOLOG cellular component organization or biogenesis#GO:0071840;protein-RNA complex organization#GO:0071826;protein-RNA complex assembly#GO:0022618;protein-containing complex organization#GO:0043933;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;cellular component assembly#GO:0022607;ribonucleoprotein complex biogenesis#GO:0022613 nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 HUMAN|HGNC=37646|UniProtKB=D3W0D1 D3W0D1 KLRF2 PTHR46746:SF6 KILLER CELL LECTIN-LIKE RECEPTOR SUBFAMILY F MEMBER 2 KILLER CELL LECTIN-LIKE RECEPTOR SUBFAMILY F MEMBER 2 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=24099|UniProtKB=Q8IUR5 Q8IUR5 TMTC1 PTHR44809:SF1 DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE PROTEIN O-MANNOSYL-TRANSFERASE TMTC1 catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758;glycosyltransferase activity#GO:0016757;mannosyltransferase activity#GO:0000030 glycoprotein metabolic process#GO:0009100;protein O-linked glycosylation via mannose#GO:0035269;metabolic process#GO:0008152;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein O-linked glycosylation#GO:0006493;carbohydrate derivative metabolic process#GO:1901135;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101;biosynthetic process#GO:0009058 HUMAN|HGNC=22192|UniProtKB=Q12765 Q12765 SCRN1 PTHR12994:SF7 SECERNIN SECERNIN-1 HUMAN|HGNC=1474|UniProtKB=P40121 P40121 CAPG PTHR11977:SF127 VILLIN MACROPHAGE-CAPPING PROTEIN cytoskeletal protein binding#GO:0008092;phospholipid binding#GO:0005543;phosphatidylinositol phosphate binding#GO:1901981;actin filament binding#GO:0051015;actin binding#GO:0003779;ion binding#GO:0043167;phosphatidylinositol-4,5-bisphosphate binding#GO:0005546;binding#GO:0005488;small molecule binding#GO:0036094;anion binding#GO:0043168;lipid binding#GO:0008289;protein-containing complex binding#GO:0044877;protein binding#GO:0005515;phosphatidylinositol bisphosphate binding#GO:1902936 regulation of supramolecular fiber organization#GO:1902903;negative regulation of organelle organization#GO:0010639;negative regulation of cellular component organization#GO:0051129;regulation of actin filament depolymerization#GO:0030834;negative regulation of supramolecular fiber organization#GO:1902904;regulation of protein polymerization#GO:0032271;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794;actin cytoskeleton organization#GO:0030036;actin filament capping#GO:0051693;negative regulation of protein polymerization#GO:0032272;actin filament-based process#GO:0030029;negative regulation of protein-containing complex assembly#GO:0031333;supramolecular fiber organization#GO:0097435;system development#GO:0048731;negative regulation of cytoskeleton organization#GO:0051494;negative regulation of protein-containing complex disassembly#GO:0043242;anatomical structure development#GO:0048856;regulation of actin filament organization#GO:0110053;actin polymerization or depolymerization#GO:0008154;biological regulation#GO:0065007;regulation of actin polymerization or depolymerization#GO:0008064;negative regulation of protein depolymerization#GO:1901880;regulation of actin filament polymerization#GO:0030833;multicellular organismal process#GO:0032501;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;regulation of actin filament-based process#GO:0032970;actin filament organization#GO:0007015;regulation of protein depolymerization#GO:1901879;regulation of biological process#GO:0050789;regulation of cellular component size#GO:0032535;regulation of organelle organization#GO:0033043;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;regulation of protein-containing complex assembly#GO:0043254;negative regulation of actin filament polymerization#GO:0030837;regulation of cellular component biogenesis#GO:0044087;cell projection organization#GO:0030030;central nervous system development#GO:0007417;regulation of cellular component organization#GO:0051128;regulation of actin filament length#GO:0030832;animal gross anatomical part developmental process#GO:0160108;negative regulation of actin filament depolymerization#GO:0030835;regulation of biological quality#GO:0065008;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;regulation of protein-containing complex disassembly#GO:0043244;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;regulation of actin cytoskeleton organization#GO:0032956;nervous system development#GO:0007399;cellular component assembly#GO:0022607;regulation of anatomical structure size#GO:0090066;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;actin cytoskeleton#GO:0015629;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;cellular anatomical structure#GO:0110165 actin or actin-binding cytoskeletal protein#PC00041;non-motor actin binding protein#PC00165 FAS signaling pathway#P00020>Gelsolin#P00611 HUMAN|HGNC=9192|UniProtKB=P19388 P19388 POLR2E PTHR10535:SF0 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1 catalytic activity, acting on RNA#GO:0140098;transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772 DNA-templated transcription elongation#GO:0006354;transcription by RNA polymerase I#GO:0006360;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;transcription by RNA polymerase II#GO:0006366;macromolecule metabolic process#GO:0043170;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;transcription by RNA polymerase III#GO:0006383;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070 nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;RNA polymerase II, core complex#GO:0005665;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;RNA polymerase II, holoenzyme#GO:0016591;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;nucleolus#GO:0005730;RNA polymerase I complex#GO:0005736;intracellular organelle#GO:0043229;RNA polymerase III complex#GO:0005666;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234 RNA metabolism protein#PC00031;DNA-directed RNA polymerase#PC00019 General transcription regulation#P00023>RNA Polymerase II#P00660;Transcription regulation by bZIP transcription factor#P00055>RNA Polymerase II#P01388 HUMAN|HGNC=11271|UniProtKB=O43610 O43610 SPRY3 PTHR12365:SF9 SPROUTY PROTEIN SPROUTY HOMOLOG 3 molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;enzyme inhibitor activity#GO:0004857;protein kinase regulator activity#GO:0019887;protein kinase inhibitor activity#GO:0004860;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;kinase inhibitor activity#GO:0019210 negative regulation of response to stimulus#GO:0048585;regulation of ERK1 and ERK2 cascade#GO:0070372;negative regulation of ERK1 and ERK2 cascade#GO:0070373;negative regulation of signal transduction#GO:0009968;regulation of epidermal growth factor receptor signaling pathway#GO:0042058;regulation of signal transduction#GO:0009966;regulation of cellular response to growth factor stimulus#GO:0090287;regulation of fibroblast growth factor receptor signaling pathway#GO:0040036;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of MAPK cascade#GO:0043408;regulation of small GTPase mediated signal transduction#GO:0051056;negative regulation of biological process#GO:0048519;negative regulation of MAPK cascade#GO:0043409;regulation of biological process#GO:0050789;regulation of ERBB signaling pathway#GO:1901184;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;negative regulation of intracellular signal transduction#GO:1902532;regulation of Ras protein signal transduction#GO:0046578;negative regulation of cell communication#GO:0010648 scaffold/adaptor protein#PC00226 FGF signaling pathway#P00021>Spry#P00626;EGF receptor signaling pathway#P00018>Spry#P00541;EGF receptor signaling pathway#P00018>SPRY#G01511 HUMAN|HGNC=5041|UniProtKB=P31943 P31943 HNRNPH1 PTHR13976:SF60 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN H binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 biological regulation#GO:0065007;regulation of RNA splicing#GO:0043484;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 RNA splicing factor#PC00148;RNA metabolism protein#PC00031;RNA processing factor#PC00147 HUMAN|HGNC=8931|UniProtKB=P15735 P15735 PHKG2 PTHR24347:SF390 SERINE/THREONINE-PROTEIN KINASE PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, LIVER_TESTIS ISOFORM catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;calcium/calmodulin-dependent protein kinase activity#GO:0004683 energy derivation by oxidation of organic compounds#GO:0015980;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;cell communication#GO:0007154;energy reserve metabolic process#GO:0006112;polysaccharide metabolic process#GO:0005976;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;carbohydrate metabolic process#GO:0005975;primary metabolic process#GO:0044238;glucan metabolic process#GO:0044042;glycogen metabolic process#GO:0005977;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;transferase complex, transferring phosphorus-containing groups#GO:0061695;transferase complex#GO:1990234;catalytic complex#GO:1902494;serine/threonine protein kinase complex#GO:1902554;protein kinase complex#GO:1902911;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Phosphorylase b kinase#P00716 HUMAN|HGNC=29016|UniProtKB=O15063 O15063 GARRE1 PTHR15703:SF3 RIKEN CDNA 4931406P16 GENE GRANULE ASSOCIATED RAC AND RHOG EFFECTOR PROTEIN 1 protein-containing complex binding#GO:0044877;binding#GO:0005488 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;intracellular signaling cassette#GO:0141124;small GTPase-mediated signal transduction#GO:0007264;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;intracellular signal transduction#GO:0035556;Rac protein signal transduction#GO:0016601;cell communication#GO:0007154 HUMAN|HGNC=29911|UniProtKB=Q13901 Q13901 C1D PTHR15341:SF3 SUN-COR STEROID HORMONE RECEPTOR CO-REPRESSOR NUCLEAR NUCLEIC ACID-BINDING PROTEIN C1D nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723;DNA binding#GO:0003677 nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;regulation of biological process#GO:0050789;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;maturation of 5.8S rRNA#GO:0000460;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;RNA processing#GO:0006396;biosynthetic process#GO:0009058;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467 membraneless organelle#GO:0043228;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233 transcription cofactor#PC00217 HUMAN|HGNC=6047|UniProtKB=Q16891 Q16891 IMMT PTHR15415:SF7 MITOFILIN MICOS COMPLEX SUBUNIT MIC60 HUMAN|HGNC=23572|UniProtKB=Q14149 Q14149 MORC3 PTHR23336:SF17 ZINC FINGER CW-TYPE COILED-COIL DOMAIN PROTEIN 3. MORC FAMILY CW-TYPE ZINC FINGER PROTEIN 3 chromatin-protein adaptor activity#GO:0140463;histone reader activity#GO:0140566;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;histone H3 reader activity#GO:0140006 innate immune response#GO:0045087;defense response#GO:0006952;response to external stimulus#GO:0009605;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;defense response to symbiont#GO:0140546;immune response#GO:0006955;defense response to other organism#GO:0098542;response to other organism#GO:0051707;immune system process#GO:0002376;response to virus#GO:0009615;defense response to virus#GO:0051607;antiviral innate immune response#GO:0140374;response to stimulus#GO:0050896;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419 nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;nuclear body#GO:0016604;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;PML body#GO:0016605;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=10818|UniProtKB=P51688 P51688 SGSH PTHR43108:SF6 N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER N-SULPHOGLUCOSAMINE SULPHOHYDROLASE catalytic activity#GO:0003824;hydrolase activity#GO:0016787 proteoglycan metabolic process#GO:0006029;aminoglycan catabolic process#GO:0006026;macromolecule metabolic process#GO:0043170;glycoprotein metabolic process#GO:0009100;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;protein metabolic process#GO:0019538;glycosaminoglycan catabolic process#GO:0006027;protein catabolic process#GO:0030163;aminoglycan metabolic process#GO:0006022;carbohydrate derivative catabolic process#GO:1901136;catabolic process#GO:0009056;primary metabolic process#GO:0044238;glycosaminoglycan metabolic process#GO:0030203 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;lytic vacuole#GO:0000323;lysosome#GO:0005764;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;vacuole#GO:0005773;cellular anatomical structure#GO:0110165;organelle#GO:0043226 hydrolase#PC00121 HUMAN|HGNC=7969|UniProtKB=Q14994 Q14994 NR1I3 PTHR24082:SF231 NUCLEAR HORMONE RECEPTOR NUCLEAR RECEPTOR SUBFAMILY 1 GROUP I MEMBER 3 signaling receptor activity#GO:0038023;sequence-specific DNA binding#GO:0043565;transcription regulator activity#GO:0140110;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;nuclear receptor activity#GO:0004879;cis-regulatory region sequence-specific DNA binding#GO:0000987;molecular transducer activity#GO:0060089 positive regulation of transcription by RNA polymerase II#GO:0045944;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604;negative regulation of DNA-templated transcription#GO:0045892;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 C4 zinc finger nuclear receptor#PC00169 HUMAN|HGNC=7634|UniProtKB=Q13075 Q13075 NAIP PTHR46914:SF1 BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 1 BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 1 cysteine-type endopeptidase inhibitor activity#GO:0004869;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;peptidase regulator activity#GO:0061134;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414;molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866;enzyme inhibitor activity#GO:0004857 regulation of apoptotic process#GO:0042981;defense response#GO:0006952;response to external stimulus#GO:0009605;response to stress#GO:0006950;detection of stimulus#GO:0051606;response to biotic stimulus#GO:0009607;response to other organism#GO:0051707;biological regulation#GO:0065007;defense response to bacterium#GO:0042742;inflammatory response#GO:0006954;response to bacterium#GO:0009617;regulation of biological process#GO:0050789;regulation of programmed cell death#GO:0043067;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 cytosol#GO:0005829;canonical inflammasome complex#GO:0061702;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 viral or transposable element protein#PC00237 HUMAN|HGNC=445|UniProtKB=Q7Z333 Q7Z333 SETX PTHR10887:SF552 DNA2/NAM7 HELICASE FAMILY HELICASE SENATAXIN transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;RNA binding#GO:0003723;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;termination of RNA polymerase II transcription#GO:0006369;transcription by RNA polymerase II#GO:0006366;macromolecule metabolic process#GO:0043170;DNA-templated transcription termination#GO:0006353;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351 RNA helicase#PC00032 HUMAN|HGNC=26200|UniProtKB=Q9H668 Q9H668 STN1 PTHR13989:SF58 REPLICATION PROTEIN A-RELATED CST COMPLEX SUBUNIT STN1 nucleic acid binding#GO:0003676;binding#GO:0005488;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;telomeric repeat DNA binding#GO:0042162 metabolic process#GO:0008152;DNA metabolic process#GO:0006259;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;telomere organization#GO:0032200;chromosome organization#GO:0051276;telomere maintenance#GO:0000723;organelle organization#GO:0006996;cellular component organization#GO:0016043;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular process#GO:0009987;telomere maintenance via telomere lengthening#GO:0010833;nucleobase-containing compound metabolic process#GO:0006139 cellular anatomical structure#GO:0110165;organelle#GO:0043226;protein-DNA complex#GO:0032993;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;nuclear telomere cap complex#GO:0000783;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;chromosome, telomeric repeat region#GO:0140445;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;chromosome, telomeric region#GO:0000781;intracellular membraneless organelle#GO:0043232;nucleus#GO:0005634;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513 HUMAN|HGNC=14880|UniProtKB=Q969Y2 Q969Y2 GTPBP3 PTHR42714:SF9 TRNA MODIFICATION GTPASE GTPBP3 5-TAURINOMETHYLURIDINE-[TRNA] SYNTHASE SUBUNIT GTPB3, MITOCHONDRIAL tRNA modification#GO:0006400;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;tRNA wobble uridine modification#GO:0002098;tRNA wobble base modification#GO:0002097;methylation#GO:0032259;RNA methylation#GO:0001510;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187;macromolecule methylation#GO:0043414;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;tRNA methylation#GO:0030488;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031;RNA methyltransferase#PC00033 HUMAN|HGNC=25062|UniProtKB=Q7Z7H3 Q7Z7H3 CATIP PTHR15505:SF3 RIIA DOMAIN-CONTAINING PROTEIN 1 CILIOGENESIS-ASSOCIATED TTC17-INTERACTING PROTEIN cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;actin filament organization#GO:0007015;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton organization#GO:0007010;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;actin polymerization or depolymerization#GO:0008154;cilium organization#GO:0044782;supramolecular fiber organization#GO:0097435;actin filament-based process#GO:0030029;actin cytoskeleton organization#GO:0030036;cell projection organization#GO:0030030;actin filament polymerization#GO:0030041;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;protein polymerization#GO:0051258 HUMAN|HGNC=12925|UniProtKB=P52738 P52738 ZNF140 PTHR24377:SF36 IP01015P-RELATED ZINC FINGER PROTEIN 140 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=18915|UniProtKB=A8MTY7 A8MTY7 KRTAP9-7 PTHR23262:SF133 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 9-6-RELATED structural protein#PC00211 HUMAN|HGNC=756|UniProtKB=P45381 P45381 ASPA PTHR15162:SF9 ASPARTOACYLASE ASPARTOACYLASE hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;catalytic activity#GO:0003824;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=971|UniProtKB=P56945 P56945 BCAR1 PTHR10654:SF15 CAS SCAFFOLDING PROTEIN BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 1 cell surface receptor signaling pathway#GO:0007166;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;signaling#GO:0023052;biological regulation#GO:0065007;cell motility#GO:0048870;cell migration#GO:0016477;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 cell junction#GO:0030054;anchoring junction#GO:0070161;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;plasma membrane#GO:0005886;focal adhesion#GO:0005925;cell-substrate junction#GO:0030055 Integrin signalling pathway#P00034>p130CAS#P00908;CCKR signaling map#P06959>CAS#P07180 HUMAN|HGNC=8891|UniProtKB=P52209 P52209 PGD PTHR11811:SF50 6-PHOSPHOGLUCONATE DEHYDROGENASE 6-PHOSPHOGLUCONATE DEHYDROGENASE, DECARBOXYLATING oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;purine nucleotide binding#GO:0017076;catalytic activity#GO:0003824;heterocyclic compound binding#GO:1901363;oxidoreductase activity#GO:0016491;nucleotide binding#GO:0000166;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;small molecule binding#GO:0036094;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;phosphogluconate dehydrogenase (decarboxylating) activity#GO:0004616 NADP+ metabolic process#GO:0006739;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;nicotinamide nucleotide metabolic process#GO:0046496;carbohydrate derivative metabolic process#GO:1901135;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091;pentose-phosphate shunt, oxidative branch#GO:0009051;nucleobase-containing small molecule metabolic process#GO:0055086;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;small molecule metabolic process#GO:0044281;glucose 6-phosphate metabolic process#GO:0051156;nucleoside phosphate metabolic process#GO:0006753;pentose-phosphate shunt#GO:0006098;NADPH regeneration#GO:0006740;pyridine-containing compound metabolic process#GO:0072524;nucleotide metabolic process#GO:0009117 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 dehydrogenase#PC00092 Pentose phosphate pathway#P02762>Gluconate Dehydrogenase#P03070 HUMAN|HGNC=45241|UniProtKB=Q2QD12 Q2QD12 RPEL1 PTHR11749:SF19 RIBULOSE-5-PHOSPHATE-3-EPIMERASE RIBULOSE-PHOSPHATE 3-EPIMERASE-LIKE PROTEIN 1 isomerase activity#GO:0016853;racemase and epimerase activity#GO:0016854;catalytic activity#GO:0003824;racemase and epimerase activity, acting on carbohydrates and derivatives#GO:0016857;cation binding#GO:0043169;metal ion binding#GO:0046872;D-ribulose-phosphate 3-epimerase activity#GO:0004750;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167 nucleobase-containing small molecule metabolic process#GO:0055086;generation of precursor metabolites and energy#GO:0006091;metabolic process#GO:0008152;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;aldehyde metabolic process#GO:0006081;nicotinamide nucleotide metabolic process#GO:0046496;carbohydrate derivative metabolic process#GO:1901135;NADP+ metabolic process#GO:0006739;organophosphate metabolic process#GO:0019637;nucleotide metabolic process#GO:0009117;NADPH regeneration#GO:0006740;pyridine-containing compound metabolic process#GO:0072524;glyceraldehyde-3-phosphate metabolic process#GO:0019682;pentose-phosphate shunt#GO:0006098;nucleoside phosphate metabolic process#GO:0006753;pentose-phosphate shunt, non-oxidative branch#GO:0009052;carbohydrate metabolic process#GO:0005975;small molecule metabolic process#GO:0044281;glucose 6-phosphate metabolic process#GO:0051156;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 Ascorbate degradation#P02729>L-xylulose-5-phosphate-3-epimerase#P02852 HUMAN|HGNC=33703|UniProtKB=A0PJX0 A0PJX0 CIB4 PTHR45791:SF4 CALCIUM AND INTEGRIN BINDING FAMILY MEMBER 2 CALCIUM AND INTEGRIN-BINDING FAMILY MEMBER 4 small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;calcium ion binding#GO:0005509;metal ion binding#GO:0046872;magnesium ion binding#GO:0000287;cation binding#GO:0043169 HUMAN|HGNC=15515|UniProtKB=Q5VV41 Q5VV41 ARHGEF16 PTHR12845:SF3 GUANINE NUCLEOTIDE EXCHANGE FACTOR RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 16 guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589 regulation of small GTPase mediated signal transduction#GO:0051056;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;regulation of actin filament-based process#GO:0032970;regulation of actin cytoskeleton organization#GO:0032956;regulation of cell communication#GO:0010646;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cellular process#GO:0050794;regulation of Rho protein signal transduction#GO:0035023;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789 protein-binding activity modulator#PC00095;G-protein modulator#PC00022;guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=16841|UniProtKB=Q99732 Q99732 LITAF PTHR23292:SF2 LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR metal ion binding#GO:0046872;cation binding#GO:0043169;ion binding#GO:0043167;zinc ion binding#GO:0008270;small molecule binding#GO:0036094;binding#GO:0005488;transition metal ion binding#GO:0046914 regulation of biological process#GO:0050789;regulation of cytokine production#GO:0001817;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of multicellular organismal process#GO:0051239;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 vacuolar membrane#GO:0005774;lytic vacuole#GO:0000323;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;late endosome membrane#GO:0031902;cytoplasmic side of membrane#GO:0098562;late endosome#GO:0005770;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;vacuole#GO:0005773;membrane#GO:0016020;vesicle membrane#GO:0012506;nucleus#GO:0005634;lysosomal membrane#GO:0005765;side of membrane#GO:0098552;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endosome membrane#GO:0010008;endosome#GO:0005768;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;lytic vacuole membrane#GO:0098852;lysosome#GO:0005764;vesicle#GO:0031982 scaffold/adaptor protein#PC00226 HUMAN|HGNC=18254|UniProtKB=Q96HZ4 Q96HZ4 HES6 PTHR10985:SF11 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED TRANSCRIPTION COFACTOR HES-6 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of multicellular organismal process#GO:0051239;negative regulation of macromolecule biosynthetic process#GO:0010558;multicellular organism development#GO:0007275;anterior/posterior pattern specification#GO:0009952;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of multicellular organismal development#GO:2000026;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of nucleobase-containing compound metabolic process#GO:0019219;regionalization#GO:0003002;multicellular organismal process#GO:0032501;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;regulation of cell development#GO:0060284;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;regulation of cell differentiation#GO:0045595;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of developmental process#GO:0050793;regulation of neurogenesis#GO:0050767;regulation of DNA-templated transcription#GO:0006355;regulation of nervous system development#GO:0051960;anatomical structure development#GO:0048856;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;pattern specification process#GO:0007389 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=30910|UniProtKB=Q6PCB0 Q6PCB0 VWA1 PTHR24020:SF77 COLLAGEN ALPHA VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 1 extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;cellular anatomical structure#GO:0110165 extracellular matrix structural protein#PC00103 HUMAN|HGNC=28490|UniProtKB=Q8NDZ4 Q8NDZ4 DIPK2A PTHR32073:SF6 GH11358P DIVERGENT PROTEIN KINASE DOMAIN 2A regulation of intracellular signal transduction#GO:1902531;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of apoptotic process#GO:0042981;regulation of signaling#GO:0023051;regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051896;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;negative regulation of programmed cell death#GO:0043069;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;negative regulation of apoptotic process#GO:0043066;regulation of cell communication#GO:0010646;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007 coated membrane#GO:0048475;membrane coat#GO:0030117;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;coated vesicle#GO:0030135;intracellular organelle#GO:0043229;extracellular region#GO:0005576;organelle#GO:0043226;COPI vesicle coat#GO:0030126;cellular anatomical structure#GO:0110165;coated vesicle membrane#GO:0030662;Golgi-associated vesicle membrane#GO:0030660;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;Golgi-associated vesicle#GO:0005798;Golgi apparatus#GO:0005794;COPI-coated vesicle#GO:0030137;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;vesicle coat#GO:0030120;cytoplasm#GO:0005737;vesicle membrane#GO:0012506;membrane#GO:0016020 HUMAN|HGNC=2699|UniProtKB=O15523 O15523 DDX3Y PTHR47958:SF72 ATP-DEPENDENT RNA HELICASE DBP3 ATP-DEPENDENT RNA HELICASE DDX3Y ATP-dependent activity#GO:0140657;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723;macromolecular conformation isomerase activity#GO:0120543;catalytic activity#GO:0003824;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;RNA helicase activity#GO:0003724;isomerase activity#GO:0016853;catalytic activity, acting on RNA#GO:0140098;helicase activity#GO:0004386 negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;regulation of cellular process#GO:0050794;gamete generation#GO:0007276;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;reproductive process#GO:0022414;negative regulation of metabolic process#GO:0009892;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;multicellular organismal reproductive process#GO:0048609;sexual reproduction#GO:0019953 P granule#GO:0043186;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;supramolecular complex#GO:0099080;organelle#GO:0043226;ribonucleoprotein granule#GO:0035770;nucleus#GO:0005634 RNA helicase#PC00032 HUMAN|HGNC=6845|UniProtKB=Q13163 Q13163 MAP2K5 PTHR48013:SF36 DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5 protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824 cell communication#GO:0007154;MAPK cascade#GO:0000165;intracellular signal transduction#GO:0035556;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;intracellular signaling cassette#GO:0141124;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 non-receptor serine/threonine protein kinase#PC00167 CCKR signaling map#P06959>MAP2K5#P07160 HUMAN|HGNC=17255|UniProtKB=P50748 P50748 KNTC1 PTHR15688:SF1 KINETOCHORE-ASSOCIATED PROTEIN 1 KINETOCHORE-ASSOCIATED PROTEIN 1 protein binding#GO:0005515;small GTPase binding#GO:0031267;binding#GO:0005488;enzyme binding#GO:0019899 chromosome segregation#GO:0007059;regulation of chromosome segregation#GO:0051983;negative regulation of cell cycle#GO:0045786;mitotic spindle assembly checkpoint signaling#GO:0007094;regulation of cell cycle process#GO:0010564;cell cycle checkpoint signaling#GO:0000075;cellular component assembly#GO:0022607;negative regulation of mitotic sister chromatid separation#GO:2000816;kinetochore assembly#GO:0051382;negative regulation of mitotic cell cycle#GO:0045930;regulation of mitotic cell cycle phase transition#GO:1901990;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;signaling#GO:0023052;regulation of sister chromatid segregation#GO:0033045;negative regulation of cell cycle process#GO:0010948;regulation of chromosome organization#GO:0033044;regulation of mitotic nuclear division#GO:0007088;intracellular protein localization#GO:0008104;regulation of mitotic sister chromatid separation#GO:0010965;regulation of mitotic cell cycle#GO:0007346;macromolecule localization#GO:0033036;mitotic sister chromatid segregation#GO:0000070;negative regulation of nuclear division#GO:0051784;regulation of nuclear division#GO:0051783;negative regulation of chromosome organization#GO:2001251;organelle assembly#GO:0070925;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;localization#GO:0051179;organelle fission#GO:0048285;mitotic cell cycle checkpoint signaling#GO:0007093;negative regulation of cellular component organization#GO:0051129;mitotic cell cycle#GO:0000278;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;negative regulation of metaphase/anaphase transition of cell cycle#GO:1902100;negative regulation of mitotic sister chromatid segregation#GO:0033048;negative regulation of chromosome segregation#GO:0051985;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;signal transduction#GO:0007165;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;negative regulation of sister chromatid segregation#GO:0033046;regulation of chromosome separation#GO:1905818;negative regulation of mitotic cell cycle phase transition#GO:1901991;nuclear division#GO:0000280;protein-containing complex assembly#GO:0065003;regulation of biological process#GO:0050789;negative regulation of mitotic nuclear division#GO:0045839;mitotic nuclear division#GO:0140014;cell cycle process#GO:0022402;regulation of organelle organization#GO:0033043;negative regulation of biological process#GO:0048519;negative regulation of cell cycle phase transition#GO:1901988;nuclear chromosome segregation#GO:0098813;sister chromatid segregation#GO:0000819;regulation of cell cycle#GO:0051726;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;negative regulation of cellular process#GO:0048523;negative regulation of chromosome separation#GO:1905819;mitotic cell cycle process#GO:1903047;chromosome organization#GO:0051276;protein localization to kinetochore#GO:0034501;biological regulation#GO:0065007;regulation of mitotic metaphase/anaphase transition#GO:0030071;regulation of mitotic sister chromatid segregation#GO:0033047;kinetochore organization#GO:0051383;negative regulation of mitotic metaphase/anaphase transition#GO:0045841;cellular response to stimulus#GO:0051716;regulation of cell cycle phase transition#GO:1901987;cell cycle#GO:0007049;negative regulation of organelle organization#GO:0010639;protein localization to organelle#GO:0033365;regulation of cellular process#GO:0050794 spindle microtubule#GO:0005876;microtubule#GO:0005874;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;chromosome#GO:0005694;kinetochore#GO:0000776;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cytoskeleton#GO:0005856;chromosome, centromeric region#GO:0000775;condensed chromosome#GO:0000793;spindle#GO:0005819;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;condensed chromosome, centromeric region#GO:0000779;microtubule cytoskeleton#GO:0015630 HUMAN|HGNC=15984|UniProtKB=Q7Z2E3 Q7Z2E3 APTX PTHR12486:SF4 APRATAXIN-RELATED APRATAXIN pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;damaged DNA binding#GO:0003684;hydrolase activity, acting on acid anhydrides#GO:0016817;nucleic acid binding#GO:0003676;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;double-stranded RNA binding#GO:0003725;single-stranded DNA binding#GO:0003697;hydrolase activity#GO:0016787;RNA binding#GO:0003723;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690 cellular response to stress#GO:0033554;DNA damage response#GO:0006974;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;nucleobase-containing compound metabolic process#GO:0006139;response to stimulus#GO:0050896 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 damaged DNA-binding protein#PC00086;DNA metabolism protein#PC00009 HUMAN|HGNC=12371|UniProtKB=Q8WYR4 Q8WYR4 RSPH1 PTHR43215:SF18 RADIAL SPOKE HEAD 1 HOMOLOG RADIAL SPOKE HEAD 1 HOMOLOG cellular process#GO:0009987;cell projection assembly#GO:0030031;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cellular process involved in reproduction in multicellular organism#GO:0022412;cell development#GO:0048468;gamete generation#GO:0007276;cell projection organization#GO:0030030;cell differentiation#GO:0030154;spermatid differentiation#GO:0048515;cilium organization#GO:0044782;plasma membrane bounded cell projection organization#GO:0120036;male gamete generation#GO:0048232;spermatogenesis#GO:0007283;developmental process#GO:0032502;plasma membrane bounded cell projection assembly#GO:0120031;cellular developmental process#GO:0048869;germ cell development#GO:0007281;developmental process involved in reproduction#GO:0003006;reproductive process#GO:0022414;microtubule bundle formation#GO:0001578;spermatid development#GO:0007286;sexual reproduction#GO:0019953;organelle assembly#GO:0070925;multicellular organismal reproductive process#GO:0048609;axoneme assembly#GO:0035082;microtubule cytoskeleton organization#GO:0000226;anatomical structure development#GO:0048856 nucleus#GO:0005634;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;motile cilium#GO:0031514;organelle#GO:0043226;cellular anatomical structure#GO:0110165;sperm flagellum#GO:0036126;intracellular organelle#GO:0043229;9+2 motile cilium#GO:0097729;cilium#GO:0005929;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=29237|UniProtKB=Q9ULE0 Q9ULE0 WWC3 PTHR14791:SF25 BOMB/KIRA PROTEINS PROTEIN WWC3 kinase binding#GO:0019900;binding#GO:0005488;enzyme binding#GO:0019899;protein binding#GO:0005515 cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of multicellular organismal process#GO:0051239;regulation of nucleobase-containing compound metabolic process#GO:0019219;cell migration#GO:0016477;regulation of response to stimulus#GO:0048583;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of growth#GO:0040008;negative regulation of biological process#GO:0048519;negative regulation of multicellular organismal process#GO:0051241;regulation of developmental process#GO:0050793;regulation of cell communication#GO:0010646;regulation of hippo signaling#GO:0035330;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;cell motility#GO:0048870;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=7788|UniProtKB=Q14938 Q14938 NFIX PTHR11492:SF3 NUCLEAR FACTOR I NUCLEAR FACTOR 1 X-TYPE transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HUMAN|HGNC=28974|UniProtKB=Q14166 Q14166 TTLL12 PTHR46088:SF1 TUBULIN--TYROSINE LIGASE-LIKE PROTEIN 12 TUBULIN--TYROSINE LIGASE-LIKE PROTEIN 12 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=28713|UniProtKB=Q5T6C5 Q5T6C5 ATXN7L2 PTHR15117:SF5 ATAXIN 7 RELATED ATAXIN-7-LIKE PROTEIN 2 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 HUMAN|HGNC=4175|UniProtKB=P50440 P50440 GATM PTHR10488:SF1 GLYCINE AMIDINOTRANSFERASE, MITOCHONDRIAL GLYCINE AMIDINOTRANSFERASE, MITOCHONDRIAL transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring one-carbon groups#GO:0016741 small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;monocarboxylic acid biosynthetic process#GO:0072330;carboxylic acid biosynthetic process#GO:0046394;cellular process#GO:0009987;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;modified amino acid metabolic process#GO:0006575;biosynthetic process#GO:0009058;small molecule metabolic process#GO:0044281 mitochondrion#GO:0005739;mitochondrial envelope#GO:0005740;organelle envelope#GO:0031967;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;mitochondrial intermembrane space#GO:0005758;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;transferase#PC00220 HUMAN|HGNC=21015|UniProtKB=Q7Z7B0 Q7Z7B0 FILIP1 PTHR23166:SF3 FILAMIN/GPBP-INTERACTING PROTEIN FILAMIN-A-INTERACTING PROTEIN 1 localization#GO:0051179;protein localization to organelle#GO:0033365;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;protein localization to cytoskeleton#GO:0044380 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;actin cytoskeleton#GO:0015629;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232 HUMAN|HGNC=10877|UniProtKB=Q9NYZ4 Q9NYZ4 SIGLEC8 PTHR12035:SF106 SIALIC ACID BINDING IMMUNOGLOBULIN-LIKE LECTIN SIALIC ACID-BINDING IG-LIKE LECTIN 8 organic acid binding#GO:0043177;ion binding#GO:0043167;carbohydrate derivative binding#GO:0097367;carboxylic acid binding#GO:0031406;small molecule binding#GO:0036094;binding#GO:0005488;anion binding#GO:0043168 cellular process#GO:0009987;cell adhesion#GO:0007155 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 immunoglobulin superfamily cell adhesion molecule#PC00125;cell adhesion molecule#PC00069 HUMAN|HGNC=4964|UniProtKB=P17693 P17693 HLA-G PTHR16675:SF297 MHC CLASS I-RELATED HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, ALPHA CHAIN G protein binding#GO:0005515;antigen binding#GO:0003823;peptide binding#GO:0042277;binding#GO:0005488;signaling receptor binding#GO:0005102 positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;positive regulation of leukocyte mediated immunity#GO:0002705;positive regulation of biological process#GO:0048518;immune response#GO:0006955;positive regulation of cellular process#GO:0048522;positive regulation of immune system process#GO:0002684;biological regulation#GO:0065007;positive regulation of immune effector process#GO:0002699;positive regulation of response to stimulus#GO:0048584;regulation of immune response#GO:0050776;regulation of cell killing#GO:0031341;regulation of lymphocyte mediated immunity#GO:0002706;immune system process#GO:0002376;regulation of leukocyte mediated cytotoxicity#GO:0001910;positive regulation of lymphocyte mediated immunity#GO:0002708;antigen processing and presentation#GO:0019882;regulation of immune effector process#GO:0002697;regulation of leukocyte mediated immunity#GO:0002703;regulation of biological process#GO:0050789;positive regulation of adaptive immune response#GO:0002821;response to stimulus#GO:0050896;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;cell periphery#GO:0071944;membrane#GO:0016020;side of membrane#GO:0098552;extracellular region#GO:0005576;external side of plasma membrane#GO:0009897 major histocompatibility complex protein#PC00149;defense/immunity protein#PC00090 HUMAN|HGNC=29802|UniProtKB=Q96BX8 Q96BX8 MOB3A PTHR22599:SF10 MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB MOB KINASE ACTIVATOR 3A molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;protein kinase regulator activity#GO:0019887;enzyme activator activity#GO:0008047;protein kinase activator activity#GO:0030295;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;kinase activator activity#GO:0019209 cell communication#GO:0007154;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 kinase activator#PC00138 HUMAN|HGNC=5439|UniProtKB=P15260 P15260 IFNGR1 PTHR20859:SF5 INTERFERON/INTERLEUKIN RECEPTOR INTERFERON GAMMA RECEPTOR 1 immune receptor activity#GO:0140375;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;cytokine receptor activity#GO:0004896;transmembrane signaling receptor activity#GO:0004888 response to peptide#GO:1901652;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;cytokine-mediated signaling pathway#GO:0019221;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to cytokine#GO:0034097;response to chemical#GO:0042221;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;signal transduction#GO:0007165 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 Interferon-gamma signaling pathway#P00035>IFNGR1#P00959;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Cytokine receptor#P00866 HUMAN|HGNC=31927|UniProtKB=Q9BZX4 Q9BZX4 ROPN1B PTHR14952:SF12 ROPPORIN-1-LIKE PROTEIN ROPPORIN-1B sperm motility#GO:0097722;germ cell development#GO:0007281;anatomical structure maturation#GO:0071695;developmental process involved in reproduction#GO:0003006;cell development#GO:0048468;cellular process involved in reproduction in multicellular organism#GO:0022412;reproductive process#GO:0022414;cell motility#GO:0048870;gamete generation#GO:0007276;microtubule-based movement#GO:0007018;cell differentiation#GO:0030154;spermatid development#GO:0007286;cilium or flagellum-dependent cell motility#GO:0001539;sexual reproduction#GO:0019953;cilium movement#GO:0003341;spermatid differentiation#GO:0048515;multicellular organismal reproductive process#GO:0048609;anatomical structure development#GO:0048856;cilium-dependent cell motility#GO:0060285;cellular process#GO:0009987;cilium movement involved in cell motility#GO:0060294;sperm capacitation#GO:0048240;male gamete generation#GO:0048232;developmental maturation#GO:0021700;spermatogenesis#GO:0007283;developmental process#GO:0032502;flagellated sperm motility#GO:0030317;microtubule-based process#GO:0007017;cellular developmental process#GO:0048869;cell maturation#GO:0048469 plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;motile cilium#GO:0031514;organelle#GO:0043226;cilium#GO:0005929;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=21188|UniProtKB=A2A368 A2A368 MAGEB16 PTHR11736:SF145 MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN MELANOMA-ASSOCIATED ANTIGEN B16 regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 scaffold/adaptor protein#PC00226 HUMAN|HGNC=6700|UniProtKB=Q14114 Q14114 LRP8 PTHR24270:SF3 LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 8 animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;localization#GO:0051179;anatomical structure development#GO:0048856;central nervous system development#GO:0007417;endocytosis#GO:0006897;developmental process#GO:0032502;transport#GO:0006810;receptor-mediated endocytosis#GO:0006898;multicellular organism development#GO:0007275;establishment of localization#GO:0051234;import into cell#GO:0098657;cellular process#GO:0009987;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;vesicle-mediated transport#GO:0016192 membrane microdomain#GO:0098857;plasma membrane raft#GO:0044853;caveola#GO:0005901;membrane#GO:0016020;membrane raft#GO:0045121;cell periphery#GO:0071944;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transfer/carrier protein#PC00219;apolipoprotein#PC00052 HUMAN|HGNC=11693|UniProtKB=Q5JU00 Q5JU00 DRC5 PTHR24107:SF27 YNEIN REGULATORY COMPLEX SUBUNIT 5 DYNEIN REGULATORY COMPLEX SUBUNIT 5 microtubule-based movement#GO:0007018;microtubule-based process#GO:0007017;cellular process#GO:0009987 microtubule or microtubule-binding cytoskeletal protein#PC00157;non-motor microtubule binding protein#PC00166;cytoskeletal protein#PC00085 HUMAN|HGNC=24936|UniProtKB=Q96AZ1 Q96AZ1 EEF1AKMT3 PTHR14614:SF5 HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN EEF1A LYSINE METHYLTRANSFERASE 3 lysine N-methyltransferase activity#GO:0016278;protein-lysine N-methyltransferase activity#GO:0016279;N-methyltransferase activity#GO:0008170;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;catalytic activity, acting on a protein#GO:0140096;protein methyltransferase activity#GO:0008276;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring one-carbon groups#GO:0016741 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260 HUMAN|HGNC=8486|UniProtKB=Q8NGU1 Q8NGU1 OR9A1P PTHR24242:SF126 G-PROTEIN COUPLED RECEPTOR OLFACTORY RECEPTOR 9A1 G-protein coupled receptor#PC00021 HUMAN|HGNC=812|UniProtKB=P16615 P16615 ATP2A2 PTHR42861:SF176 CALCIUM-TRANSPORTING ATPASE SARCOPLASMIC_ENDOPLASMIC RETICULUM CALCIUM ATPASE 2 ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;P-type ion transporter activity#GO:0015662;monoatomic ion transmembrane transporter activity#GO:0015075;primary active transmembrane transporter activity#GO:0015399;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804 cellular response to stimulus#GO:0051716;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;metal ion transport#GO:0030001;homeostatic process#GO:0042592;regulation of heart contraction#GO:0008016;organelle assembly#GO:0070925;localization#GO:0051179;cell communication#GO:0007154;monoatomic cation transport#GO:0006812;vacuole organization#GO:0007033;intracellular signal transduction#GO:0035556;biological regulation#GO:0065007;macroautophagy#GO:0016236;monoatomic ion transmembrane transport#GO:0034220;regulation of system process#GO:0044057;intracellular monoatomic cation homeostasis#GO:0030003;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;establishment of localization#GO:0051234;intracellular chemical homeostasis#GO:0055082;calcium-mediated signaling#GO:0019722;cellular homeostasis#GO:0019725;intracellular monoatomic ion homeostasis#GO:0006873;regulation of muscle system process#GO:0090257;calcium ion transmembrane transport#GO:0070588;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signaling#GO:0023052;regulation of muscle contraction#GO:0006937;calcium ion homeostasis#GO:0055074;inorganic ion homeostasis#GO:0098771;transmembrane transport#GO:0055085;process utilizing autophagic mechanism#GO:0061919;monoatomic ion transport#GO:0006811;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;monoatomic ion homeostasis#GO:0050801;autophagy#GO:0006914;signal transduction#GO:0007165;cellular process#GO:0009987;autophagosome organization#GO:1905037;cellular component assembly#GO:0022607;monoatomic cation transmembrane transport#GO:0098655;regulation of multicellular organismal process#GO:0051239;intracellular signaling cassette#GO:0141124;metabolic process#GO:0008152;chemical homeostasis#GO:0048878;cellular component organization or biogenesis#GO:0071840;intracellular calcium ion homeostasis#GO:0006874;calcium ion transport#GO:0006816;autophagosome assembly#GO:0000045 cellular anatomical structure#GO:0110165;membrane#GO:0016020 primary active transporter#PC00068 HUMAN|HGNC=9350|UniProtKB=Q9NQX0 Q9NQX0 PRDM6 PTHR16515:SF22 PR DOMAIN ZINC FINGER PROTEIN HISTONE-LYSINE N-METHYLTRANSFERASE PRDM6-RELATED regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HUMAN|HGNC=20868|UniProtKB=Q8N680 Q8N680 ZBTB2 PTHR24399:SF0 ZINC FINGER AND BTB DOMAIN-CONTAINING ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 2 sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription repressor activity#GO:0001217;transcription regulator activity#GO:0140110;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700 regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523;regulation of multicellular organismal process#GO:0051239;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of cytokine production#GO:0001817 cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218 HUMAN|HGNC=16065|UniProtKB=Q9NS18 Q9NS18 GLRX2 PTHR46679:SF1 FAMILY NOT NAMED GLUTAREDOXIN-2, MITOCHONDRIAL disulfide oxidoreductase activity#GO:0015036;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491;protein-disulfide reductase activity#GO:0015035;catalytic activity#GO:0003824;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667 HUMAN|HGNC=6522|UniProtKB=P04180 P04180 LCAT PTHR11440:SF18 LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED PHOSPHATIDYLCHOLINE-STEROL ACYLTRANSFERASE acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746 primary metabolic process#GO:0044238;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 acyltransferase#PC00042;transferase#PC00220 HUMAN|HGNC=20986|UniProtKB=Q8NB12 Q8NB12 SMYD1 PTHR12197:SF184 HISTONE-LYSINE N-METHYLTRANSFERASE SMYD HISTONE-LYSINE N-METHYLTRANSFERASE SMYD1 histone methyltransferase activity#GO:0042054;protein-lysine N-methyltransferase activity#GO:0016279;N-methyltransferase activity#GO:0008170;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;histone H3K4 methyltransferase activity#GO:0042800;lysine N-methyltransferase activity#GO:0016278;histone modifying activity#GO:0140993;histone H3 methyltransferase activity#GO:0140938;protein methyltransferase activity#GO:0008276;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a protein#GO:0140096 negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;circulatory system development#GO:0072359;negative regulation of metabolic process#GO:0009892;animal gross anatomical part developmental process#GO:0160108;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of macromolecule biosynthetic process#GO:0010558;heart development#GO:0007507;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;multicellular organism development#GO:0007275;animal organ development#GO:0048513;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 histone modifying enzyme#PC00261 HUMAN|HGNC=21304|UniProtKB=Q9NX46 Q9NX46 ADPRS PTHR16222:SF24 ADP-RIBOSYLGLYCOHYDROLASE ADP-RIBOSYLHYDROLASE ARH3 catalytic activity#GO:0003824;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity, acting on a protein#GO:0140096;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787 metabolic process#GO:0008152;cellular response to chemical stress#GO:0062197;response to oxidative stress#GO:0006979;macromolecule metabolic process#GO:0043170;response to reactive oxygen species#GO:0000302;response to stress#GO:0006950;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987;response to chemical#GO:0042221;cellular response to oxidative stress#GO:0034599;cellular response to chemical stimulus#GO:0070887;cellular response to stress#GO:0033554;response to oxygen-containing compound#GO:1901700;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;primary metabolic process#GO:0044238;protein modification process#GO:0036211;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;intracellular organelle lumen#GO:0070013 hydrolase#PC00121 HUMAN|HGNC=28243|UniProtKB=Q3KRA9 Q3KRA9 ALKBH6 PTHR46030:SF1 ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6 RNA_DNA DEMETHYLASE ALKBH6-RELATED dioxygenase activity#GO:0051213;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 oxidoreductase#PC00176;oxygenase#PC00177 HUMAN|HGNC=29991|UniProtKB=Q58A45 Q58A45 PAN3 PTHR12272:SF11 DEADENYLATION COMPLEX SUBUNIT PAN3 PAN2-PAN3 DEADENYLATION COMPLEX SUBUNIT PAN3 binding#GO:0005488;nucleic acid binding#GO:0003676;poly(A) binding#GO:0008143;RNA binding#GO:0003723;single-stranded RNA binding#GO:0003727 RNA catabolic process#GO:0006401;positive regulation of metabolic process#GO:0009893;RNA metabolic process#GO:0016070;regulation of biological quality#GO:0065008;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;regulation of mRNA stability#GO:0043488;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;positive regulation of mRNA metabolic process#GO:1903313;mRNA destabilization#GO:0061157;regulation of mRNA metabolic process#GO:1903311;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;RNA destabilization#GO:0050779;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA stability#GO:0043487;regulation of RNA metabolic process#GO:0051252;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;positive regulation of mRNA catabolic process#GO:0061014;catabolic process#GO:0009056;nuclear-transcribed mRNA poly(A) tail shortening#GO:0000289;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;macromolecule metabolic process#GO:0043170;positive regulation of catabolic process#GO:0009896;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;regulation of primary metabolic process#GO:0080090;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;nucleic acid catabolic process#GO:0141188;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494 exoribonuclease#PC00099 HUMAN|HGNC=15937|UniProtKB=O00762 O00762 UBE2C PTHR24068:SF360 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2 C ubiquitin-like protein conjugating enzyme activity#GO:0061650;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity, acting on a protein#GO:0140096;ubiquitin conjugating enzyme activity#GO:0061631;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740 regulation of mitotic cell cycle phase transition#GO:1901990;modification-dependent macromolecule catabolic process#GO:0043632;anaphase-promoting complex-dependent catabolic process#GO:0031145;protein catabolic process#GO:0030163;protein modification by small protein conjugation or removal#GO:0070647;regulation of sister chromatid segregation#GO:0033045;regulation of cell cycle#GO:0051726;regulation of cellular component organization#GO:0051128;regulation of organelle organization#GO:0033043;protein polyubiquitination#GO:0000209;protein modification by small protein conjugation#GO:0032446;regulation of biological process#GO:0050789;regulation of chromosome segregation#GO:0051983;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;proteasomal protein catabolic process#GO:0010498;regulation of cell cycle process#GO:0010564;protein ubiquitination#GO:0016567;cellular process#GO:0009987;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;modification-dependent protein catabolic process#GO:0019941;protein modification process#GO:0036211;primary metabolic process#GO:0044238;regulation of cell cycle phase transition#GO:1901987;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;regulation of chromosome organization#GO:0033044;post-translational protein modification#GO:0043687;biological regulation#GO:0065007;regulation of mitotic metaphase/anaphase transition#GO:0030071;regulation of mitotic cell cycle#GO:0007346 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 ubiquitin-protein ligase#PC00234 Ubiquitin proteasome pathway#P00060>E2#P01491 HUMAN|HGNC=17435|UniProtKB=Q9BXP2 Q9BXP2 SLC12A9 PTHR11827:SF98 SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS SOLUTE CARRIER FAMILY 12 MEMBER 9 monoatomic cation transmembrane transporter activity#GO:0008324;potassium ion transmembrane transporter activity#GO:0015079;symporter activity#GO:0015293;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;monoatomic ion transmembrane transporter activity#GO:0015075;solute:monoatomic cation symporter activity#GO:0015294;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic anion transmembrane transporter activity#GO:0008509;secondary active transmembrane transporter activity#GO:0015291;chloride transmembrane transporter activity#GO:0015108 cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;potassium ion transmembrane transport#GO:0071805;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813;transport#GO:0006810;monoatomic ion transport#GO:0006811;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179 plasma membrane#GO:0005886;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;apical part of cell#GO:0045177;cell periphery#GO:0071944;apical plasma membrane#GO:0016324;membrane#GO:0016020 secondary carrier transporter#PC00258 HUMAN|HGNC=25190|UniProtKB=Q96BT1 Q96BT1 C3orf49 PTHR36473:SF1 CHROMOSOME 3 OPEN READING FRAME 49 GENE 11100-RELATED HUMAN|HGNC=6449|UniProtKB=Q14532 Q14532 KRT32 PTHR23239:SF155 INTERMEDIATE FILAMENT KERATIN, TYPE I CUTICULAR HA2 structural molecule activity#GO:0005198 intermediate filament cytoskeleton organization#GO:0045104;cell differentiation#GO:0030154;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;supramolecular fiber organization#GO:0097435;anatomical structure development#GO:0048856;tissue morphogenesis#GO:0048729;intermediate filament organization#GO:0045109;animal gross anatomical part developmental process#GO:0160108;intermediate filament-based process#GO:0045103;cytoskeleton organization#GO:0007010;tissue development#GO:0009888;epithelial cell differentiation#GO:0030855;epithelium development#GO:0060429;cellular process#GO:0009987;organelle organization#GO:0006996;morphogenesis of an epithelium#GO:0002009;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;developmental process#GO:0032502 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;supramolecular fiber#GO:0099512;intermediate filament#GO:0005882;intracellular anatomical structure#GO:0005622;supramolecular complex#GO:0099080;organelle#GO:0043226;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232 intermediate filament#PC00129 HUMAN|HGNC=6156|UniProtKB=P05106 P05106 ITGB3 PTHR10082:SF25 INTEGRIN BETA SUBUNIT INTEGRIN BETA-3 protein-containing complex binding#GO:0044877;integrin binding#GO:0005178;protein binding#GO:0005515;cell adhesion molecule binding#GO:0050839;signaling receptor binding#GO:0005102;binding#GO:0005488 hemostasis#GO:0007599;integrin-mediated signaling pathway#GO:0007229;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;cell motility#GO:0048870;regulation of body fluid levels#GO:0050878;response to stimulus#GO:0050896;signaling#GO:0023052;cell activation#GO:0001775;cell-matrix adhesion#GO:0007160;cell adhesion#GO:0007155;cell communication#GO:0007154;cell-substrate adhesion#GO:0031589;wound healing#GO:0042060;regulation of biological quality#GO:0065008;response to wounding#GO:0009611;response to stress#GO:0006950;cell-cell adhesion#GO:0098609;cellular process#GO:0009987;signal transduction#GO:0007165;coagulation#GO:0050817;multicellular organismal process#GO:0032501;cell migration#GO:0016477;homotypic cell-cell adhesion#GO:0034109;biological regulation#GO:0065007;cell surface receptor signaling pathway#GO:0007166;platelet aggregation#GO:0070527;cell adhesion mediated by integrin#GO:0033627;platelet activation#GO:0030168;blood coagulation#GO:0007596 integrin complex#GO:0008305;anchoring junction#GO:0070161;cellular anatomical structure#GO:0110165;synapse#GO:0045202;cell-substrate junction#GO:0030055;focal adhesion#GO:0005925;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;protein complex involved in cell adhesion#GO:0098636;cell junction#GO:0030054;signaling receptor complex#GO:0043235;cell surface#GO:0009986;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 integrin#PC00126 Integrin signalling pathway#P00034>Integrin beta#P00931;Blood coagulation#P00011>GP IIIa#P00458 HUMAN|HGNC=12391|UniProtKB=Q99614 Q99614 TTC1 PTHR46014:SF1 TETRATRICOPEPTIDE REPEAT PROTEIN 1 TETRATRICOPEPTIDE REPEAT PROTEIN 1 HUMAN|HGNC=7237|UniProtKB=Q9Y6F6 Q9Y6F6 IRAG1 PTHR15352:SF2 LYMPHOID-RESTRICTED MEMBRANE PROTEIN, JAW1 INOSITOL 1,4,5-TRIPHOSPHATE RECEPTOR ASSOCIATED 1 scaffold/adaptor protein#PC00226 HUMAN|HGNC=9191|UniProtKB=O15514 O15514 POLR2D PTHR21297:SF0 DNA-DIRECTED RNA POLYMERASE II DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB4 translation initiation factor binding#GO:0031369;protein binding#GO:0005515;binding#GO:0005488 RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;DNA-templated transcription initiation#GO:0006352;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;transcription by RNA polymerase II#GO:0006366;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;transcription initiation at RNA polymerase II promoter#GO:0006367;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;RNA polymerase II, core complex#GO:0005665;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;membrane-bounded organelle#GO:0043227;RNA polymerase II, holoenzyme#GO:0016591;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;protein-containing complex#GO:0032991;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;membrane-enclosed lumen#GO:0031974;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234 DNA-directed RNA polymerase#PC00019;RNA metabolism protein#PC00031 General transcription regulation#P00023>RNA Polymerase II#P00660;Transcription regulation by bZIP transcription factor#P00055>RNA Polymerase II#P01388 HUMAN|HGNC=26918|UniProtKB=Q0VAQ4 Q0VAQ4 SMAGP PTHR47394:SF1 SMALL CELL ADHESION GLYCOPROTEIN SMALL CELL ADHESION GLYCOPROTEIN HUMAN|HGNC=376|UniProtKB=Q13023 Q13023 AKAP6 PTHR14514:SF2 PKA ANCHORING PROTEIN A-KINASE ANCHOR PROTEIN 6 protein-membrane adaptor activity#GO:0043495;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 regulation of biological quality#GO:0065008;regulation of biological process#GO:0050789;regulation of transmembrane transport#GO:0034762;regulation of muscle system process#GO:0090257;regulation of cellular process#GO:0050794;regulation of metal ion transport#GO:0010959;regulation of monoatomic cation transmembrane transport#GO:1904062;regulation of system process#GO:0044057;regulation of release of sequestered calcium ion into cytosol#GO:0051279;regulation of transport#GO:0051049;regulation of localization#GO:0032879;regulation of membrane potential#GO:0042391;regulation of monoatomic ion transmembrane transport#GO:0034765;regulation of multicellular organismal process#GO:0051239;regulation of calcium ion transport#GO:0051924;biological regulation#GO:0065007;regulation of monoatomic ion transport#GO:0043269 sarcoplasmic reticulum#GO:0016529;nucleus#GO:0005634;membrane#GO:0016020;nuclear envelope#GO:0005635;cytoplasm#GO:0005737;endomembrane system#GO:0012505;endoplasmic reticulum#GO:0005783;nuclear membrane#GO:0031965;organelle membrane#GO:0031090;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;sarcoplasm#GO:0016528;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=9979|UniProtKB=O75678 O75678 RFPL2 PTHR24103:SF657 E3 UBIQUITIN-PROTEIN LIGASE TRIM RET FINGER PROTEIN-LIKE 1-RELATED catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659 immune system process#GO:0002376;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;regulation of biological process#GO:0050789;innate immune response#GO:0045087;regulation of biosynthetic process#GO:0009889;response to external stimulus#GO:0009605;regulation of gene expression#GO:0010468;defense response#GO:0006952;defense response to other organism#GO:0098542;biological regulation#GO:0065007;response to other organism#GO:0051707;response to biotic stimulus#GO:0009607;regulation of macromolecule biosynthetic process#GO:0010556;response to stress#GO:0006950;regulation of metabolic process#GO:0019222;immune response#GO:0006955;defense response to symbiont#GO:0140546 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=19743|UniProtKB=Q9UKY4 Q9UKY4 POMT2 PTHR10050:SF46 DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE PROTEIN O-MANNOSYL-TRANSFERASE 2 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 transferase#PC00220;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=11148|UniProtKB=Q16658 Q16658 FSCN1 PTHR10551:SF23 FASCIN FASCIN protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;actin filament binding#GO:0051015 cellular component organization or biogenesis#GO:0071840;actin filament organization#GO:0007015;cellular component assembly#GO:0022607;cell migration#GO:0016477;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;supramolecular fiber organization#GO:0097435;establishment or maintenance of cell polarity#GO:0007163;actin filament-based process#GO:0030029;actin cytoskeleton organization#GO:0030036;cell motility#GO:0048870;cellular component organization#GO:0016043;actin filament bundle assembly#GO:0051017;actin filament bundle organization#GO:0061572 cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;ruffle#GO:0001726;membrane#GO:0016020;cell leading edge#GO:0031252;cell periphery#GO:0071944;neuron projection#GO:0043005;lamellipodium#GO:0030027;plasma membrane region#GO:0098590;cytoplasm#GO:0005737;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;filopodium#GO:0030175;growth cone#GO:0030426;intracellular organelle#GO:0043229;axon#GO:0030424;cell projection membrane#GO:0031253;intracellular anatomical structure#GO:0005622;site of polarized growth#GO:0030427;actin cytoskeleton#GO:0015629;actin-based cell projection#GO:0098858;microvillus#GO:0005902;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;distal axon#GO:0150034;cell projection#GO:0042995 non-motor actin binding protein#PC00165 HUMAN|HGNC=37148|UniProtKB=A6NLI5 A6NLI5 TRIM64C PTHR24103:SF575 E3 UBIQUITIN-PROTEIN LIGASE TRIM TRIPARTITE MOTIF-CONTAINING PROTEIN 64C ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 immune system process#GO:0002376;regulation of biological process#GO:0050789;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;response to external stimulus#GO:0009605;regulation of gene expression#GO:0010468;defense response#GO:0006952;innate immune response#GO:0045087;regulation of biosynthetic process#GO:0009889;defense response to symbiont#GO:0140546;immune response#GO:0006955;response to biotic stimulus#GO:0009607;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;response to stress#GO:0006950;biological regulation#GO:0065007;response to other organism#GO:0051707;defense response to other organism#GO:0098542 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=28907|UniProtKB=Q6UXX5 Q6UXX5 ITIH6 PTHR10338:SF155 INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H6 protein-binding activity modulator#PC00095;protease inhibitor#PC00191 HUMAN|HGNC=19596|UniProtKB=P0C646 P0C646 OR52Z1P PTHR26450:SF63 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 52Z1P olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=17801|UniProtKB=Q8NHY6 Q8NHY6 ZFP28 PTHR24377:SF212 IP01015P-RELATED ZINC FINGER PROTEIN 28 HOMOLOG cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=2062|UniProtKB=O00299 O00299 CLIC1 PTHR43920:SF2 CHLORIDE INTRACELLULAR CHANNEL, ISOFORM A CHLORIDE INTRACELLULAR CHANNEL PROTEIN 1 monoatomic anion transmembrane transporter activity#GO:0008509;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;chloride channel activity#GO:0005254;chloride transmembrane transporter activity#GO:0015108;passive transmembrane transporter activity#GO:0022803;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;channel activity#GO:0015267;monoatomic anion channel activity#GO:0005253 localization#GO:0051179;establishment of localization#GO:0051234;inorganic anion transport#GO:0015698;monoatomic ion transport#GO:0006811;chloride transport#GO:0006821;monoatomic anion transport#GO:0006820;transport#GO:0006810 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HUMAN|HGNC=15985|UniProtKB=Q4LDE5 Q4LDE5 SVEP1 PTHR19325:SF43 COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING SUSHI, VON WILLEBRAND FACTOR TYPE A, EGF AND PENTRAXIN DOMAIN-CONTAINING PROTEIN 1 anatomical structure morphogenesis#GO:0009653;tissue development#GO:0009888;multicellular organismal process#GO:0032501;circulatory system development#GO:0072359;epidermis development#GO:0008544;animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502;anatomical structure development#GO:0048856;multicellular organism development#GO:0007275;vasculature development#GO:0001944;system development#GO:0048731 complement component#PC00078;defense/immunity protein#PC00090 HUMAN|HGNC=48|UniProtKB=O75027 O75027 ABCB7 PTHR24221:SF402 ATP-BINDING CASSETTE SUB-FAMILY B IRON-SULFUR CLUSTERS TRANSPORTER ABCB7, MITOCHONDRIAL ATP-dependent activity#GO:0140657;transporter activity#GO:0005215;ATPase-coupled transmembrane transporter activity#GO:0042626;transmembrane transporter activity#GO:0022857;active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399 chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;transport#GO:0006810;inorganic ion homeostasis#GO:0098771;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;monoatomic ion homeostasis#GO:0050801;intracellular monoatomic ion homeostasis#GO:0006873;cellular process#GO:0009987;intracellular iron ion homeostasis#GO:0006879;homeostatic process#GO:0042592 organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;membrane#GO:0016020;organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227 ATP-binding cassette (ABC) transporter#PC00003 HUMAN|HGNC=17116|UniProtKB=Q8NEC5 Q8NEC5 CATSPER1 PTHR47193:SF1 CATION CHANNEL SPERM-ASSOCIATED PROTEIN 1 CATION CHANNEL SPERM-ASSOCIATED PROTEIN 1 channel activity#GO:0015267;voltage-gated calcium channel activity#GO:0005245;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;voltage-gated channel activity#GO:0022832;transporter activity#GO:0005215;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216 microtubule-based process#GO:0007017;calcium ion transport#GO:0006816;cellular process#GO:0009987;cilium movement involved in cell motility#GO:0060294;cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;cilium-dependent cell motility#GO:0060285;sperm motility#GO:0097722;regulation of biological process#GO:0050789;gamete generation#GO:0007276;regulation of microtubule-based movement#GO:0060632;transport#GO:0006810;spermatogenesis#GO:0007283;developmental process#GO:0032502;flagellated sperm motility#GO:0030317;establishment of localization#GO:0051234;regulation of locomotion#GO:0040012;biological regulation#GO:0065007;male gamete generation#GO:0048232;sexual reproduction#GO:0019953;regulation of microtubule-based process#GO:0032886;multicellular organismal reproductive process#GO:0048609;monoatomic cation transport#GO:0006812;regulation of cell motility#GO:2000145;localization#GO:0051179;developmental process involved in reproduction#GO:0003006;reproductive process#GO:0022414;metal ion transport#GO:0030001;microtubule-based movement#GO:0007018;cell motility#GO:0048870;regulation of cellular process#GO:0050794 transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cation channel complex#GO:0034703;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;CatSper complex#GO:0036128;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;calcium channel complex#GO:0034704;voltage-gated calcium channel complex#GO:0005891;membrane#GO:0016020;membrane protein complex#GO:0098796 ion channel#PC00133 HUMAN|HGNC=11264|UniProtKB=P22532 P22532 SPRR2D PTHR48553:SF3 SMALL PROLINE-RICH PROTEIN 2E SMALL PROLINE-RICH PROTEIN 2D HUMAN|HGNC=12012|UniProtKB=P06753 P06753 TPM3 PTHR19269:SF38 TROPOMYOSIN TROPOMYOSIN ALPHA-3 CHAIN binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;actin filament binding#GO:0051015;protein binding#GO:0005515;protein-containing complex binding#GO:0044877 actin filament-based process#GO:0030029;muscle contraction#GO:0006936;system process#GO:0003008;actin filament organization#GO:0007015;supramolecular fiber organization#GO:0097435;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;muscle system process#GO:0003012;cellular component organization#GO:0016043;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;multicellular organismal process#GO:0032501 cytoskeleton#GO:0005856;actin filament#GO:0005884;intracellular organelle#GO:0043229;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;actin cytoskeleton#GO:0015629;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;supramolecular complex#GO:0099080;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232 actin binding motor protein#PC00040 HUMAN|HGNC=17174|UniProtKB=Q9UJ70 Q9UJ70 NAGK PTHR12862:SF0 BADF TYPE ATPASE DOMAIN-CONTAINING PROTEIN N-ACETYL-D-GLUCOSAMINE KINASE transferase activity#GO:0016740;catalytic activity#GO:0003824;carbohydrate kinase activity#GO:0019200;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 HUMAN|HGNC=22214|UniProtKB=Q7Z6L1 Q7Z6L1 TECPR1 PTHR23250:SF16 DYSFERLIN-RELATED TECTONIN BETA-PROPELLER REPEAT-CONTAINING PROTEIN 1 lipid binding#GO:0008289;phosphatidylinositol-3-phosphate binding#GO:0032266;phosphatidylinositol phosphate binding#GO:1901981;binding#GO:0005488;phospholipid binding#GO:0005543 metabolic process#GO:0008152;autophagosome maturation#GO:0097352;cellular component organization or biogenesis#GO:0071840;cellular component disassembly#GO:0022411;process utilizing autophagic mechanism#GO:0061919;protein-containing complex organization#GO:0043933;cellular component organization#GO:0016043;autophagy#GO:0006914;cellular process#GO:0009987;catabolic process#GO:0009056;protein-containing complex disassembly#GO:0032984;macroautophagy#GO:0016236 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;lytic vacuole membrane#GO:0098852;lysosome#GO:0005764;intracellular anatomical structure#GO:0005622;autophagosome membrane#GO:0000421;membrane-bounded organelle#GO:0043227;autophagosome#GO:0005776;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;vacuole#GO:0005773;membrane#GO:0016020;lysosomal membrane#GO:0005765;vacuolar membrane#GO:0005774;lytic vacuole#GO:0000323;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588 HUMAN|HGNC=14512|UniProtKB=Q92552 Q92552 MRPS27 PTHR21393:SF0 MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S27 SMALL RIBOSOMAL SUBUNIT PROTEIN MS27 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739 ribosomal protein#PC00202 HUMAN|HGNC=3612|UniProtKB=P06734 P06734 FCER2 PTHR22802:SF325 C-TYPE LECTIN SUPERFAMILY MEMBER LOW AFFINITY IMMUNOGLOBULIN EPSILON FC RECEPTOR binding#GO:0005488;signaling receptor activity#GO:0038023;carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187;molecular transducer activity#GO:0060089 response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897 membrane traffic protein#PC00150 HUMAN|HGNC=22800|UniProtKB=A8MTJ3 A8MTJ3 GNAT3 PTHR10218:SF66 GTP-BINDING PROTEIN ALPHA SUBUNIT GUANINE NUCLEOTIDE-BINDING PROTEIN G(T) SUBUNIT ALPHA-3 catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111;molecular function regulator activity#GO:0098772;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924;hydrolase activity#GO:0016787 regulation of biological process#GO:0050789;sensory perception of bitter taste#GO:0050913;cellular response to stimulus#GO:0051716;detection of chemical stimulus#GO:0009593;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;sensory perception#GO:0007600;nervous system process#GO:0050877;detection of chemical stimulus involved in sensory perception of taste#GO:0050912;G protein-coupled receptor signaling pathway#GO:0007186;detection of chemical stimulus involved in sensory perception#GO:0050907;cell communication#GO:0007154;signal transduction#GO:0007165;cellular process#GO:0009987;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;biological regulation#GO:0065007;response to chemical#GO:0042221;multicellular organismal process#GO:0032501;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;sensory perception of taste#GO:0050909;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;detection of chemical stimulus involved in sensory perception of bitter taste#GO:0001580 protein-containing complex#GO:0032991;cytoplasm#GO:0005737;plasma membrane#GO:0005886;membrane#GO:0016020;9+0 non-motile cilium#GO:0097731;photoreceptor cell cilium#GO:0097733;cell periphery#GO:0071944;neuron projection#GO:0043005;extrinsic component of plasma membrane#GO:0019897;extrinsic component of membrane#GO:0019898;cytoplasmic side of membrane#GO:0098562;cellular anatomical structure#GO:0110165;photoreceptor outer segment#GO:0001750;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cytoplasmic side of plasma membrane#GO:0009898;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;side of membrane#GO:0098552;non-motile cilium#GO:0097730;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;photoreceptor inner segment#GO:0001917;extrinsic component of cytoplasmic side of plasma membrane#GO:0031234;cilium#GO:0005929;catalytic complex#GO:1902494 heterotrimeric G-protein#PC00117;G-protein#PC00020 HUMAN|HGNC=22977|UniProtKB=Q9BYZ8 Q9BYZ8 REG4 PTHR22803:SF147 MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED REGENERATING ISLET-DERIVED PROTEIN 4 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=28149|UniProtKB=Q9BU68 Q9BU68 PRR15L PTHR14581:SF5 FAMILY NOT NAMED PROLINE-RICH PROTEIN 15-LIKE PROTEIN HUMAN|HGNC=23726|UniProtKB=Q9H098 Q9H098 FAM107B PTHR16768:SF1 DOWN REGULATED IN RENAL CARCINOMA 1/TU3A PROTEIN FAM107B HUMAN|HGNC=24167|UniProtKB=Q8TD06 Q8TD06 AGR3 PTHR15337:SF5 ANTERIOR GRADIENT PROTEIN-RELATED ANTERIOR GRADIENT PROTEIN 3 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 oxidoreductase#PC00176;reductase#PC00198 HUMAN|HGNC=1324|UniProtKB=P0C0L5 P0C0L5 C4B PTHR11412:SF86 MACROGLOBULIN / COMPLEMENT COMPLEMENT C4-A-RELATED chemokine receptor binding#GO:0042379;protein binding#GO:0005515;molecular function activator activity#GO:0140677;signaling receptor binding#GO:0005102;binding#GO:0005488;cytokine receptor binding#GO:0005126;cytokine activity#GO:0005125;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;G protein-coupled receptor binding#GO:0001664;chemokine activity#GO:0008009 defense response to symbiont#GO:0140546;immune response#GO:0006955;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;response to other organism#GO:0051707;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;defense response to other organism#GO:0098542;response to stimulus#GO:0050896;immune system process#GO:0002376;defense response#GO:0006952;response to external stimulus#GO:0009605;innate immune response#GO:0045087 extracellular region#GO:0005576;catalytic complex#GO:1902494;extracellular protein-containing complex#GO:0140392;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 protease inhibitor#PC00191 HUMAN|HGNC=7908|UniProtKB=O60500 O60500 NPHS1 PTHR11640:SF136 NEPHRIN NEPHRIN protein binding#GO:0005515;binding#GO:0005488;cell adhesion molecule binding#GO:0050839 cell adhesion#GO:0007155;cellular process#GO:0009987;cell-cell adhesion#GO:0098609 plasma membrane#GO:0005886;anchoring junction#GO:0070161;cell junction#GO:0030054;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;cell-cell junction#GO:0005911;membrane#GO:0016020 immunoglobulin superfamily cell adhesion molecule#PC00125;cell adhesion molecule#PC00069 HUMAN|HGNC=11487|UniProtKB=Q15431 Q15431 SYCP1 PTHR46918:SF1 SYNAPTONEMAL COMPLEX PROTEIN 1 SYNAPTONEMAL COMPLEX PROTEIN 1 DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;binding#GO:0005488;nucleic acid binding#GO:0003676 synaptonemal complex assembly#GO:0007130;cellular component assembly#GO:0022607;homologous chromosome pairing at meiosis#GO:0007129;response to stress#GO:0006950;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;DNA biosynthetic process#GO:0071897;cellular component organization or biogenesis#GO:0071840;homologous chromosome segregation#GO:0045143;DNA metabolic process#GO:0006259;nucleobase-containing compound biosynthetic process#GO:0034654;meiotic cell cycle#GO:0051321;chromosome organization involved in meiotic cell cycle#GO:0070192;metabolic process#GO:0008152;DNA recombination#GO:0006310;chromosome segregation#GO:0007059;response to stimulus#GO:0050896;cellular component organization#GO:0016043;meiosis I#GO:0007127;nuclear chromosome segregation#GO:0098813;meiotic cell cycle process#GO:1903046;cell cycle process#GO:0022402;nuclear division#GO:0000280;reciprocal meiotic recombination#GO:0007131;cellular response to stress#GO:0033554;nucleic acid biosynthetic process#GO:0141187;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;macromolecule biosynthetic process#GO:0009059;meiotic nuclear division#GO:0140013;macromolecule metabolic process#GO:0043170;meiotic chromosome segregation#GO:0045132;chromosome organization#GO:0051276;DNA repair#GO:0006281;DNA damage response#GO:0006974;homologous recombination#GO:0035825;reproductive process#GO:0022414;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cell cycle#GO:0007049;cellular response to stimulus#GO:0051716;reciprocal homologous recombination#GO:0140527;organelle fission#GO:0048285;meiosis I cell cycle process#GO:0061982;sexual reproduction#GO:0019953 synaptonemal structure#GO:0099086;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;membraneless organelle#GO:0043228;condensed nuclear chromosome#GO:0000794;synaptonemal complex#GO:0000795;condensed chromosome#GO:0000793;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;chromosome#GO:0005694;organelle lumen#GO:0043233;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;central element#GO:0000801;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 HUMAN|HGNC=10250|UniProtKB=Q9HCK4 Q9HCK4 ROBO2 PTHR10075:SF127 BASIGIN RELATED ROUNDABOUT HOMOLOG 2 cell adhesion molecule#PC00069 HUMAN|HGNC=29296|UniProtKB=Q8IYE0 Q8IYE0 CCDC146 PTHR32083:SF34 CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58-RELATED COILED-COIL DOMAIN-CONTAINING PROTEIN 146 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membraneless organelle#GO:0043228;intracellular membraneless organelle#GO:0043232;intracellular anatomical structure#GO:0005622 structural protein#PC00211 HUMAN|HGNC=15239|UniProtKB=Q6IF63 Q6IF63 OR52W1 PTHR26450:SF58 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 52W1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=19193|UniProtKB=Q86U17 Q86U17 SERPINA11 PTHR11461:SF154 SERINE PROTEASE INHIBITOR, SERPIN SERPIN A11 enzyme inhibitor activity#GO:0004857;endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414;peptidase regulator activity#GO:0061134;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;serine-type endopeptidase inhibitor activity#GO:0004867 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HUMAN|HGNC=2323|UniProtKB=P31327 P31327 CPS1 PTHR11405:SF58 CARBAMOYLTRANSFERASE FAMILY MEMBER CARBAMOYL-PHOSPHATE SYNTHASE [AMMONIA], MITOCHONDRIAL ligase activity, forming carbon-nitrogen bonds#GO:0016879;ligase activity#GO:0016874;catalytic activity#GO:0003824 metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;cellular process#GO:0009987;small molecule metabolic process#GO:0044281;proteinogenic amino acid metabolic process#GO:0170039;amino acid metabolic process#GO:0006520 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 ligase#PC00142;metabolite interconversion enzyme#PC00262 De novo pyrimidine ribonucleotides biosythesis#P02740>Carbamoyl phosphate synthetase#P02925;Arginine biosynthesis#P02728>Carbamoyl phosphate synthase#P02845 HUMAN|HGNC=37451|UniProtKB=A6NJ64 A6NJ64 NPIPB2 PTHR15438:SF14 NUCLEAR PORE COMPLEX INTERACTING PROTEIN NUCLEAR PORE COMPLEX-INTERACTING PROTEIN FAMILY MEMBER A1-RELATED HUMAN|HGNC=2048|UniProtKB=P56747 P56747 CLDN6 PTHR12002:SF41 CLAUDIN CLAUDIN-6 binding#GO:0005488;protein binding#GO:0005515;virus receptor activity#GO:0001618 cellular component organization#GO:0016043;cell junction assembly#GO:0034329;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cell junction organization#GO:0034330;cellular component assembly#GO:0022607;cell-cell junction assembly#GO:0007043;cell-cell junction organization#GO:0045216;cellular component organization or biogenesis#GO:0071840 bicellular tight junction#GO:0005923;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell-cell junction#GO:0005911;cell periphery#GO:0071944;cell junction#GO:0030054;tight junction#GO:0070160;anchoring junction#GO:0070161;apical junction complex#GO:0043296 tight junction#PC00214;cell junction protein#PC00070 HUMAN|HGNC=14537|UniProtKB=P61916 P61916 NPC2 PTHR11306:SF68 NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 2 small molecule binding#GO:0036094;binding#GO:0005488;sterol binding#GO:0032934;alcohol binding#GO:0043178;lipid binding#GO:0008289;cholesterol binding#GO:0015485;steroid binding#GO:0005496 intracellular sterol transport#GO:0032366;lipid transport#GO:0006869;cholesterol efflux#GO:0033344;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;cholesterol transport#GO:0030301;macromolecule localization#GO:0033036;organic hydroxy compound transport#GO:0015850;establishment of localization#GO:0051234;cellular localization#GO:0051641;sterol transport#GO:0015918;localization#GO:0051179;transport#GO:0006810;intracellular transport#GO:0046907;lipid localization#GO:0010876 HUMAN|HGNC=1375|UniProtKB=P22748 P22748 CA4 PTHR18952:SF95 CARBONIC ANHYDRASE CARBONIC ANHYDRASE 4 catalytic activity#GO:0003824;lyase activity#GO:0016829;carbon-oxygen lyase activity#GO:0016835;hydro-lyase activity#GO:0016836 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;apical part of cell#GO:0045177;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;plasma membrane region#GO:0098590;organelle#GO:0043226;cell periphery#GO:0071944;membrane#GO:0016020;apical plasma membrane#GO:0016324 dehydratase#PC00091;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=2466|UniProtKB=Q6UVK1 Q6UVK1 CSPG4 PTHR15036:SF17 PIKACHURIN-LIKE PROTEIN CHONDROITIN SULFATE PROTEOGLYCAN 4 signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;developmental process#GO:0032502;multicellular organism development#GO:0007275;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;cell communication#GO:0007154;anatomical structure development#GO:0048856 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 cell adhesion molecule#PC00069 HUMAN|HGNC=17753|UniProtKB=P62079 P62079 TSPAN5 PTHR19282:SF63 TETRASPANIN TETRASPANIN-5 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 HUMAN|HGNC=26224|UniProtKB=Q9H5Z6 Q9H5Z6 FAM124B PTHR14715:SF2 FAM124 DOMAIN-CONTAINING PROTEIN-RELATED PROTEIN FAM124B intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 HUMAN|HGNC=817|UniProtKB=P23634 P23634 ATP2B4 PTHR24093:SF435 CATION TRANSPORTING ATPASE PLASMA MEMBRANE CALCIUM-TRANSPORTING ATPASE 4 calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;ATP-dependent activity#GO:0140657;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATPase-coupled transmembrane transporter activity#GO:0042626;P-type ion transporter activity#GO:0015662;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 homeostatic process#GO:0042592;monoatomic ion homeostasis#GO:0050801;intracellular monoatomic ion homeostasis#GO:0006873;regulation of cytosolic calcium ion concentration#GO:0051480;cellular homeostasis#GO:0019725;intracellular calcium ion homeostasis#GO:0006874;intracellular chemical homeostasis#GO:0055082;calcium ion homeostasis#GO:0055074;inorganic ion homeostasis#GO:0098771;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003 cell periphery#GO:0071944;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 primary active transporter#PC00068 HUMAN|HGNC=8038|UniProtKB=P30990 P30990 NTS PTHR15356:SF0 NEUROTENSIN/NEUROMEDIN N NEUROTENSIN_NEUROMEDIN N G protein-coupled receptor binding#GO:0001664;neuropeptide receptor binding#GO:0071855;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;signaling receptor binding#GO:0005102;binding#GO:0005488;molecular function activator activity#GO:0140677;protein binding#GO:0005515 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;neuropeptide signaling pathway#GO:0007218;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789 presynapse#GO:0098793;neuron projection#GO:0043005;cellular anatomical structure#GO:0110165;synapse#GO:0045202;neuron projection terminus#GO:0044306;cell projection#GO:0042995;distal axon#GO:0150034;plasma membrane bounded cell projection#GO:0120025;axon#GO:0030424;cell junction#GO:0030054;axon terminus#GO:0043679 HUMAN|HGNC=5249|UniProtKB=Q9UBY9 Q9UBY9 HSPB7 PTHR46907:SF2 HEAT SHOCK PROTEIN BETA-7-RELATED HEAT SHOCK PROTEIN BETA-7 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=20511|UniProtKB=Q9BTD3 Q9BTD3 TMEM121 PTHR31046:SF0 TRANSMEMBRANE PROTEIN 121 TRANSMEMBRANE PROTEIN 121 HUMAN|HGNC=24056|UniProtKB=Q8NHP1 Q8NHP1 AKR7L PTHR43625:SF11 AFLATOXIN B1 ALDEHYDE REDUCTASE AFLATOXIN B1 ALDEHYDE REDUCTASE MEMBER 4-RELATED catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;alcohol dehydrogenase (NADP+) activity#GO:0008106;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614 cellular process#GO:0009987;detoxification#GO:0098754;catabolic process#GO:0009056;response to chemical#GO:0042221;response to stimulus#GO:0050896;response to toxic substance#GO:0009636;metabolic process#GO:0008152;secondary metabolic process#GO:0019748 cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 oxidoreductase#PC00176;reductase#PC00198 HUMAN|HGNC=30015|UniProtKB=Q96LB8 Q96LB8 PGLYRP4 PTHR11022:SF40 PEPTIDOGLYCAN RECOGNITION PROTEIN PEPTIDOGLYCAN RECOGNITION PROTEIN 4 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;N-acetylmuramoyl-L-alanine amidase activity#GO:0008745;peptidoglycan muralytic activity#GO:0061783;pattern recognition receptor activity#GO:0038187;molecular transducer activity#GO:0060089;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;signaling receptor activity#GO:0038023;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810 defense response#GO:0006952;response to external stimulus#GO:0009605;defense response to bacterium#GO:0042742;response to bacterium#GO:0009617;immune system process#GO:0002376;response to other organism#GO:0051707;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;immune response#GO:0006955;defense response to Gram-positive bacterium#GO:0050830;response to stress#GO:0006950;response to biotic stimulus#GO:0009607 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090 HUMAN|HGNC=28577|UniProtKB=Q96NU7 Q96NU7 AMDHD1 PTHR42752:SF1 IMIDAZOLONEPROPIONASE IMIDAZOLONEPROPIONASE-RELATED hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides#GO:0016812;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810 oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;small molecule catabolic process#GO:0044282;amino acid metabolic process#GO:0006520;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;proteinogenic amino acid metabolic process#GO:0170039;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752 metalloprotease#PC00153 HUMAN|HGNC=23376|UniProtKB=Q5SR56 Q5SR56 SLC71A2 PTHR23504:SF32 MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10 SOLUTE CARRIER FAMILY 71 MEMBER 2 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258;transporter#PC00227 HUMAN|HGNC=14152|UniProtKB=Q9BQD7 Q9BQD7 ANTKMT PTHR13610:SF5 METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN ADENINE NUCLEOTIDE TRANSLOCASE LYSINE N-METHYLTRANSFERASE catalytic activity, acting on a protein#GO:0140096;protein methyltransferase activity#GO:0008276;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741;lysine N-methyltransferase activity#GO:0016278;protein-lysine N-methyltransferase activity#GO:0016279;N-methyltransferase activity#GO:0008170;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168 regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=30693|UniProtKB=Q5VWM3 Q5VWM3 PRAMEF18 PTHR14224:SF79 SIMILAR TO PREFERENTIALLY EXPRESSED ANTIGEN IN MELANOMA-LIKE 3 PRAME FAMILY MEMBER 18-RELATED ubiquitin-like ligase-substrate adaptor activity#GO:1990756;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;enzyme-substrate adaptor activity#GO:0140767 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941 Cul2-RING ubiquitin ligase complex#GO:0031462;transferase complex#GO:1990234;catalytic complex#GO:1902494;ubiquitin ligase complex#GO:0000151;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;cullin-RING ubiquitin ligase complex#GO:0031461 HUMAN|HGNC=4931|UniProtKB=P04439 P04439 HLA-A PTHR16675:SF251 MHC CLASS I-RELATED HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, A ALPHA CHAIN peptide binding#GO:0042277;antigen binding#GO:0003823;binding#GO:0005488;signaling receptor binding#GO:0005102;protein binding#GO:0005515 positive regulation of leukocyte mediated immunity#GO:0002705;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;positive regulation of immune system process#GO:0002684;positive regulation of cellular process#GO:0048522;immune response#GO:0006955;positive regulation of biological process#GO:0048518;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;positive regulation of immune effector process#GO:0002699;regulation of lymphocyte mediated immunity#GO:0002706;immune system process#GO:0002376;regulation of immune response#GO:0050776;regulation of cell killing#GO:0031341;positive regulation of lymphocyte mediated immunity#GO:0002708;regulation of immune effector process#GO:0002697;antigen processing and presentation#GO:0019882;regulation of leukocyte mediated cytotoxicity#GO:0001910;regulation of biological process#GO:0050789;regulation of leukocyte mediated immunity#GO:0002703;positive regulation of adaptive immune response#GO:0002821;response to stimulus#GO:0050896;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;cell surface#GO:0009986;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;side of membrane#GO:0098552;extracellular region#GO:0005576;external side of plasma membrane#GO:0009897 major histocompatibility complex protein#PC00149;defense/immunity protein#PC00090 HUMAN|HGNC=9068|UniProtKB=O14939 O14939 PLD2 PTHR18896:SF121 PHOSPHOLIPASE D PHOSPHOLIPASE D2 phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578;catalytic activity#GO:0003824;glycerophospholipase activity#GO:0004620;hydrolase activity, acting on ester bonds#GO:0016788;phospholipase activity#GO:0120569;hydrolase activity#GO:0016787;lipase activity#GO:0016298 biological regulation#GO:0065007;cellular process#GO:0009987;lipid catabolic process#GO:0016042;organophosphate metabolic process#GO:0019637;regulation of transport#GO:0051049;regulation of localization#GO:0032879;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;phospholipid metabolic process#GO:0006644;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;phospholipid catabolic process#GO:0009395;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;organophosphate catabolic process#GO:0046434 cell periphery#GO:0071944;vesicle#GO:0031982;membrane#GO:0016020;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227 lipase#PC00143;phospholipase#PC00186 Angiogenesis#P00005>PLD#P00204;Parkinson disease#P00049>PLD2#P01207;Ras Pathway#P04393>PLD#P04574 HUMAN|HGNC=26154|UniProtKB=Q2KHR3 Q2KHR3 QSER1 PTHR14709:SF2 GLUTAMINE AND SERINE-RICH PROTEIN 1-RELATED GLUTAMINE AND SERINE-RICH PROTEIN 1 HUMAN|HGNC=5193|UniProtKB=Q7LGA3 Q7LGA3 HS2ST1 PTHR12129:SF17 HEPARAN SULFATE 2-O-SULFOTRANSFERASE HEPARAN SULFATE 2-O-SULFOTRANSFERASE 1 sulfotransferase activity#GO:0008146;transferase activity, transferring sulphur-containing groups#GO:0016782;transferase activity#GO:0016740;catalytic activity#GO:0003824 proteoglycan metabolic process#GO:0006029;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;proteoglycan biosynthetic process#GO:0030166;biosynthetic process#GO:0009058;macromolecule biosynthetic process#GO:0009059;protein O-linked glycosylation#GO:0006493;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;primary metabolic process#GO:0044238;glycoprotein biosynthetic process#GO:0009101 metabolite interconversion enzyme#PC00262;transferase#PC00220 HUMAN|HGNC=5461|UniProtKB=P78318 P78318 IGBP1 PTHR10933:SF12 IMMUNOGLOBULIN-BINDING PROTEIN 1 IMMUNOGLOBULIN-BINDING PROTEIN 1 protein phosphatase regulator activity#GO:0019888;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;phosphatase regulator activity#GO:0019208 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;TOR signaling#GO:0031929;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 chaperone#PC00072 p53 pathway by glucose deprivation#P04397>alpha4#P04646 HUMAN|HGNC=2453|UniProtKB=P49674 P49674 CSNK1E PTHR11909:SF523 CASEIN KINASE-RELATED CASEIN KINASE I ISOFORM EPSILON protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824 regulation of canonical Wnt signaling pathway#GO:0060828;regulation of protein metabolic process#GO:0051246;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of proteasomal protein catabolic process#GO:0061136;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of Wnt signaling pathway#GO:0030177;positive regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032436;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;positive regulation of proteasomal protein catabolic process#GO:1901800;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signaling#GO:0023052;regulation of Wnt signaling pathway#GO:0030111;positive regulation of protein metabolic process#GO:0051247;regulation of signaling#GO:0023051;positive regulation of metabolic process#GO:0009893;positive regulation of signaling#GO:0023056;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of response to stimulus#GO:0048583;positive regulation of canonical Wnt signaling pathway#GO:0090263;positive regulation of catabolic process#GO:0009896;regulation of catabolic process#GO:0009894;positive regulation of signal transduction#GO:0009967;positive regulation of ubiquitin-dependent protein catabolic process#GO:2000060;cellular response to stimulus#GO:0051716;regulation of macromolecule metabolic process#GO:0060255;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;cell communication#GO:0007154;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434;positive regulation of protein catabolic process#GO:0045732;regulation of protein catabolic process#GO:0042176 nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 non-receptor serine/threonine protein kinase#PC00167 CCKR signaling map#P06959>CK1delta/epsilon#P07089;Wnt signaling pathway#P00057>Casein Kinase 1#P01460;Circadian clock system#P00015>Casein kinase I#P00502;Parkinson disease#P00049>Casein kinase I#P01242;Hedgehog signaling pathway#P00025>Casein kinase I#P00681 HUMAN|HGNC=5629|UniProtKB=P0DTE1 P0DTE1 IGHV3-38-3 PTHR23266:SF384 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 3-53-RELATED antigen binding#GO:0003823;binding#GO:0005488 adaptive immune response#GO:0002250;response to stimulus#GO:0050896;immune response#GO:0006955;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;immune effector process#GO:0002252;immune system process#GO:0002376 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=12099|UniProtKB=Q58FF3 Q58FF3 HSP90B2P PTHR11528:SF44 HEAT SHOCK PROTEIN 90 FAMILY MEMBER HEAT SHOCK PROTEIN 75 KDA, MITOCHONDRIAL-RELATED ribonucleotide binding#GO:0032553;hydrolase activity, acting on acid anhydrides#GO:0016817;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;ATP-dependent activity#GO:0140657;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP binding#GO:0005524;kinase binding#GO:0019900;binding#GO:0005488;nucleoside phosphate binding#GO:1901265;protein binding#GO:0005515;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleotide binding#GO:0000166;anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167;ATP hydrolysis activity#GO:0016887;hydrolase activity#GO:0016787 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;protein folding#GO:0006457;biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;mitochondrial inner membrane#GO:0005743;organelle envelope#GO:0031967;membrane#GO:0016020 chaperone#PC00072;Hsp90 family chaperone#PC00028 HUMAN|HGNC=44443|UniProtKB=C9J2P7 C9J2P7 USP17L15 PTHR24006:SF651 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE INACTIVE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 17-LIKE PROTEIN 4-RELATED cysteine-type deubiquitinase activity#GO:0004843;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787 biological regulation#GO:0065007;regulation of biological quality#GO:0065008;regulation of cellular process#GO:0050794;regulation of protein stability#GO:0031647;regulation of biological process#GO:0050789;regulation of apoptotic process#GO:0042981;regulation of programmed cell death#GO:0043067 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 protease#PC00190;cysteine protease#PC00081 HUMAN|HGNC=5990|UniProtKB=Q9UHD0 Q9UHD0 IL19 PTHR48482:SF3 INTERLEUKIN-19-RELATED INTERLEUKIN-19 molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;cytokine activity#GO:0005125 response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=19693|UniProtKB=Q9Y3A0 Q9Y3A0 COQ4 PTHR12922:SF10 UBIQUINONE BIOSYNTHESIS PROTEIN UBIQUINONE BIOSYNTHESIS PROTEIN COQ4 HOMOLOG, MITOCHONDRIAL lyase activity#GO:0016829;catalytic activity#GO:0003824;carboxy-lyase activity#GO:0016831;carbon-carbon lyase activity#GO:0016830 small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152;ubiquinone biosynthetic process#GO:0006744;ketone biosynthetic process#GO:0042181;cellular process#GO:0009987;ketone metabolic process#GO:0042180;biosynthetic process#GO:0009058;small molecule metabolic process#GO:0044281 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739 HUMAN|HGNC=18320|UniProtKB=Q7RTV3 Q7RTV3 ZNF367 PTHR23235:SF130 KRUEPPEL-LIKE TRANSCRIPTION FACTOR ZINC FINGER PROTEIN 367 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=14175|UniProtKB=Q9UJK0 Q9UJK0 TSR3 PTHR20426:SF0 RIBOSOME BIOGENESIS PROTEIN TSR3 HOMOLOG 18S RRNA AMINOCARBOXYPROPYLTRANSFERASE transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a rRNA#GO:0140102 cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;rRNA modification#GO:0000154;pseudouridine synthesis#GO:0001522 nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=11950|UniProtKB=P45378 P45378 TNNT3 PTHR11521:SF4 TROPONIN T TROPONIN T, FAST SKELETAL MUSCLE protein binding#GO:0005515;binding#GO:0005488;cytoskeletal protein binding#GO:0008092 cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;anatomical structure morphogenesis#GO:0009653;muscle system process#GO:0003012;cell differentiation#GO:0030154;cell development#GO:0048468;actomyosin structure organization#GO:0031032;skeletal muscle contraction#GO:0003009;animal gross anatomical part developmental process#GO:0160108;nervous system process#GO:0050877;striated muscle cell development#GO:0055002;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;cellular anatomical entity morphogenesis#GO:0032989;cellular component organization or biogenesis#GO:0071840;anatomical structure formation involved in morphogenesis#GO:0048646;striated muscle cell differentiation#GO:0051146;muscle cell development#GO:0055001;muscle cell differentiation#GO:0042692;myofibril assembly#GO:0030239;actin cytoskeleton organization#GO:0030036;muscle structure development#GO:0061061;striated muscle contraction#GO:0006941;cellular component assembly involved in morphogenesis#GO:0010927;organelle assembly#GO:0070925;sarcomere organization#GO:0045214;actin filament-based process#GO:0030029;neuromuscular process#GO:0050905;anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;multicellular organismal process#GO:0032501;developmental process#GO:0032502;muscle contraction#GO:0006936;cellular developmental process#GO:0048869;system process#GO:0003008 contractile muscle fiber#GO:0043292;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;cytoskeleton#GO:0005856;sarcomere#GO:0030017;membraneless organelle#GO:0043228;actin cytoskeleton#GO:0015629;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;myofibril#GO:0030016 actin binding motor protein#PC00040 HUMAN|HGNC=26678|UniProtKB=Q7Z3K6 Q7Z3K6 MIER3 PTHR10865:SF22 METASTASIS-ASSOCIATED PROTEIN AND MESODERM INDUCTION EARLY RESPONSE PROTEIN MESODERM INDUCTION EARLY RESPONSE PROTEIN 3 binding#GO:0005488;transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712;enzyme binding#GO:0019899;transcription regulator activity#GO:0140110;histone deacetylase binding#GO:0042826;protein binding#GO:0005515 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=30955|UniProtKB=Q96SQ5 Q96SQ5 ZNF587 PTHR24377:SF655 IP01015P-RELATED ZINC FINGER PROTEIN 417-RELATED sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=18479|UniProtKB=Q9UHA3 Q9UHA3 RSL24D1 PTHR10792:SF26 60S RIBOSOMAL PROTEIN L24 RIBOSOME BIOGENESIS PROTEIN RLP24-RELATED cellular process#GO:0009987;cellular component biogenesis#GO:0044085;ribosomal large subunit biogenesis#GO:0042273;ribosome biogenesis#GO:0042254;ribonucleoprotein complex biogenesis#GO:0022613;cellular component organization or biogenesis#GO:0071840 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular organelle#GO:0043229;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 ribosomal protein#PC00202 HUMAN|HGNC=1791|UniProtKB=Q16667 Q16667 CDKN3 PTHR23339:SF103 TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE CYCLIN-DEPENDENT KINASE INHIBITOR 3 phosphoprotein phosphatase activity#GO:0004721;protein tyrosine phosphatase activity#GO:0004725;hydrolase activity#GO:0016787;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HUMAN|HGNC=12669|UniProtKB=P21796 P21796 VDAC1 PTHR11743:SF13 VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL NON-SELECTIVE VOLTAGE-GATED ION CHANNEL VDAC1 voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;monoatomic anion channel activity#GO:0005253;voltage-gated channel activity#GO:0022832;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic anion transmembrane transporter activity#GO:0008509;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;voltage-gated monoatomic anion channel activity#GO:0008308 mitochondrial transport#GO:0006839;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;cellular localization#GO:0051641;localization#GO:0051179;transport#GO:0006810;mitochondrial transmembrane transport#GO:1990542;intracellular transport#GO:0046907 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;outer membrane#GO:0019867;organelle outer membrane#GO:0031968;plasma membrane#GO:0005886;cytoplasm#GO:0005737;membrane#GO:0016020;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;cell periphery#GO:0071944;mitochondrial outer membrane#GO:0005741;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588 voltage-gated ion channel#PC00241 HUMAN|HGNC=124|UniProtKB=P13686 P13686 ACP5 PTHR10161:SF68 TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5 TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5 acid phosphatase activity#GO:0003993;ferrous iron binding#GO:0008198;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;phosphoric ester hydrolase activity#GO:0042578;iron ion binding#GO:0005506;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;transition metal ion binding#GO:0046914;hydrolase activity#GO:0016787;metal ion binding#GO:0046872;cation binding#GO:0043169 anatomical structure homeostasis#GO:0060249;multicellular organismal process#GO:0032501;tissue remodeling#GO:0048771;bone remodeling#GO:0046849;homeostatic process#GO:0042592;bone resorption#GO:0045453;multicellular organismal-level homeostasis#GO:0048871;tissue homeostasis#GO:0001894 phosphatase#PC00181;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=9253|UniProtKB=P62937 P62937 PPIA PTHR11071:SF490 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 chaperone#PC00072 HUMAN|HGNC=4686|UniProtKB=O75343 O75343 GUCY1B2 PTHR45655:SF17 GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2 GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2 catalytic activity#GO:0003824;phosphorus-oxygen lyase activity#GO:0016849;cyclase activity#GO:0009975;lyase activity#GO:0016829;guanylate cyclase activity#GO:0004383 response to oxygen levels#GO:0070482;response to abiotic stimulus#GO:0009628;response to stimulus#GO:0050896 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829;catalytic complex#GO:1902494 guanylate cyclase#PC00114;cyclase#PC00079 Endothelin signaling pathway#P00019>Guanylate cyclase#P00581;Gonadotropin-releasing hormone receptor pathway#P06664>GC#P06726 HUMAN|HGNC=9766|UniProtKB=P51159 P51159 RAB27A PTHR47977:SF20 RAS-RELATED PROTEIN RAB RAS-RELATED PROTEIN RAB-27A heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;guanyl nucleotide binding#GO:0019001;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;GTPase activity#GO:0003924;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094 positive regulation of secretion#GO:0051047;secretion#GO:0046903;localization#GO:0051179;regulation of secretion#GO:0051046;regulation of exocytosis#GO:0017157;regulation of secretion by cell#GO:1903530;secretion by cell#GO:0032940;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;export from cell#GO:0140352;transport#GO:0006810;establishment of localization#GO:0051234;regulation of transport#GO:0051049;regulation of localization#GO:0032879;exocytosis#GO:0006887;cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of secretion by cell#GO:1903532;positive regulation of transport#GO:0051050;vesicle-mediated transport#GO:0016192;biological regulation#GO:0065007 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular vesicle#GO:0097708;apical plasma membrane#GO:0016324;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;melanosome#GO:0042470;plasma membrane#GO:0005886;endomembrane system#GO:0012505;plasma membrane region#GO:0098590;transport vesicle#GO:0030133;cell periphery#GO:0071944;secretory vesicle#GO:0099503;membrane#GO:0016020;apical part of cell#GO:0045177;Golgi apparatus#GO:0005794 small GTPase#PC00208 HUMAN|HGNC=33711|UniProtKB=Q68D91 Q68D91 MBLAC2 PTHR42951:SF4 METALLO-BETA-LACTAMASE DOMAIN-CONTAINING ACYL-COENZYME A THIOESTERASE MBLAC2 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HUMAN|HGNC=20652|UniProtKB=Q96J42 Q96J42 TXNDC15 PTHR14684:SF2 THIOREDOXIN DOMAIN-CONTAINING PROTEIN 15 THIOREDOXIN DOMAIN-CONTAINING PROTEIN 15 plasma membrane bounded cell projection organization#GO:0120036;cell projection organization#GO:0030030;cellular component assembly#GO:0022607;cellular process#GO:0009987;cell projection assembly#GO:0030031;cilium assembly#GO:0060271;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cilium organization#GO:0044782;cellular component organization or biogenesis#GO:0071840;organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031 cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;membrane-bounded organelle#GO:0043227;cilium#GO:0005929 HUMAN|HGNC=28773|UniProtKB=Q86V20 Q86V20 SHLD2 PTHR14495:SF2 SHIELDIN COMPLEX SUBUNIT 2 SHIELDIN COMPLEX SUBUNIT 2 regulation of response to stimulus#GO:0048583;regulation of DNA repair#GO:0006282;regulation of DNA recombination#GO:0000018;regulation of response to stress#GO:0080134;regulation of double-strand break repair#GO:2000779;regulation of cellular response to stress#GO:0080135;regulation of biological process#GO:0050789;regulation of DNA metabolic process#GO:0051052;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of double-strand break repair via homologous recombination#GO:0010569;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 intracellular anatomical structure#GO:0005622;site of DNA damage#GO:0090734;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;site of double-strand break#GO:0035861;chromosome#GO:0005694 HUMAN|HGNC=13517|UniProtKB=Q9NZA1 Q9NZA1 CLIC5 PTHR45476:SF4 CHLORIDE INTRACELLULAR CHANNEL PROTEIN 6-RELATED CHLORIDE INTRACELLULAR CHANNEL PROTEIN 5 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic anion transmembrane transporter activity#GO:0008509;monoatomic ion transmembrane transporter activity#GO:0015075 chloride transport#GO:0006821;monoatomic anion transport#GO:0006820;transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;inorganic anion transport#GO:0015698;monoatomic ion transport#GO:0006811 plasma membrane#GO:0005886;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;apical part of cell#GO:0045177;cell periphery#GO:0071944;apical plasma membrane#GO:0016324;membrane#GO:0016020 ion channel#PC00133 HUMAN|HGNC=1161|UniProtKB=Q53EZ4 Q53EZ4 CEP55 PTHR31838:SF1 CENTROSOMAL PROTEIN OF 55 KDA CENTROSOMAL PROTEIN OF 55 KDA protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 mitotic cytokinesis#GO:0000281;mitotic cell cycle#GO:0000278;cellular component organization#GO:0016043;cell cycle#GO:0007049;cell division#GO:0051301;cell cycle process#GO:0022402;mitotic cytokinetic process#GO:1902410;cytoskeleton-dependent cytokinesis#GO:0061640;localization#GO:0051179;cytokinesis#GO:0000910;cytokinetic process#GO:0032506;membrane organization#GO:0061024;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;mitotic cell cycle process#GO:1903047 cellular anatomical structure#GO:0110165;midbody#GO:0030496 HUMAN|HGNC=126|UniProtKB=P10323 P10323 ACR PTHR24252:SF8 ACROSIN-RELATED ACROSIN hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;serine-type peptidase activity#GO:0008236;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity#GO:0003824 reproductive process#GO:0022414;fertilization#GO:0009566;catabolic process#GO:0009056;cellular process#GO:0009987;acrosome reaction#GO:0007340;single fertilization#GO:0007338;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;sexual reproduction#GO:0019953;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;vesicle#GO:0031982;intracellular vesicle#GO:0097708;secretory vesicle#GO:0099503;membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;acrosomal vesicle#GO:0001669 serine protease#PC00203;protease#PC00190 HUMAN|HGNC=10002|UniProtKB=P49758 P49758 RGS6 PTHR45746:SF2 LP21163P REGULATOR OF G PROTEIN SIGNALING 6 enzyme activator activity#GO:0008047;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 cell projection#GO:0042995;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;plasma membrane bounded cell projection#GO:0120025;cellular anatomical structure#GO:0110165;neuron projection#GO:0043005 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>RGS#P00731;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>RGS#P00704 HUMAN|HGNC=11182|UniProtKB=O75808 O75808 CAPN15 PTHR10183:SF382 CALPAIN CALPAIN-15 cysteine protease#PC00081;protease#PC00190 HUMAN|HGNC=9232|UniProtKB=Q07869 Q07869 PPARA PTHR24082:SF197 NUCLEAR HORMONE RECEPTOR PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;molecular transducer activity#GO:0060089;nuclear receptor activity#GO:0004879;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription repressor activity#GO:0001217 positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;cellular response to stimulus#GO:0051716;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of lipid metabolic process#GO:0019216;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;cell communication#GO:0007154;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;response to hormone#GO:0009725;negative regulation of macromolecule biosynthetic process#GO:0010558;response to chemical#GO:0042221;positive regulation of macromolecule metabolic process#GO:0010604;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;signaling#GO:0023052;cellular response to hormone stimulus#GO:0032870;cellular response to endogenous stimulus#GO:0071495;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;cell differentiation#GO:0030154;cellular response to chemical stimulus#GO:0070887;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;hormone-mediated signaling pathway#GO:0009755;negative regulation of DNA-templated transcription#GO:0045892;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893 intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 C4 zinc finger nuclear receptor#PC00169 Gonadotropin-releasing hormone receptor pathway#P06664>PPARalpha/gamma#P06744 HUMAN|HGNC=37138|UniProtKB=B4DXR9 B4DXR9 ZNF732 PTHR24384:SF81 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED ZINC FINGER PROTEIN 732 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218 HUMAN|HGNC=16906|UniProtKB=Q9Y2Q3 Q9Y2Q3 GSTK1 PTHR42943:SF2 GLUTATHIONE S-TRANSFERASE KAPPA GLUTATHIONE S-TRANSFERASE KAPPA 1 transferase#PC00220 HUMAN|HGNC=17451|UniProtKB=Q9Y271 Q9Y271 CYSLTR1 PTHR24230:SF12 G-PROTEIN COUPLED RECEPTOR CYSTEINYL LEUKOTRIENE RECEPTOR 1 G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;neuropeptide receptor activity#GO:0008188;G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888 signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;neuropeptide signaling pathway#GO:0007218;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HUMAN|HGNC=14353|UniProtKB=O14645 O14645 DNALI1 PTHR13183:SF4 AXONEMAL INNER ARM DYNEIN LIGHT CHAIN 28 AXONEMAL DYNEIN LIGHT INTERMEDIATE POLYPEPTIDE 1 protein binding#GO:0005515;binding#GO:0005488 intracellular organelle#GO:0043229;cilium#GO:0005929;cytoskeleton#GO:0005856;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;axoneme#GO:0005930;ciliary base#GO:0097546;intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;ciliary plasm#GO:0097014 microtubule or microtubule-binding cytoskeletal protein#PC00157;cytoskeletal protein#PC00085 HUMAN|HGNC=8220|UniProtKB=Q8NGA1 Q8NGA1 OR1M1 PTHR48001:SF124 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 1M1 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cell communication#GO:0007154;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=12966|UniProtKB=Q13360 Q13360 ZNF177 PTHR24381:SF403 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 177 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=28460|UniProtKB=Q8N3J3 Q8N3J3 HROB PTHR14523:SF1 UNCHARACTERIZED PROTEIN C17ORF53 HOMOLOG HOMOLOGOUS RECOMBINATION OB-FOLD PROTEIN HUMAN|HGNC=11078|UniProtKB=Q14940 Q14940 SLC9A5 PTHR10110:SF56 SODIUM/HYDROGEN EXCHANGER SODIUM_HYDROGEN EXCHANGER 5 metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;active transmembrane transporter activity#GO:0022804;metal cation:proton antiporter activity#GO:0051139;monoatomic ion transmembrane transporter activity#GO:0015075;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;proton transmembrane transporter activity#GO:0015078;antiporter activity#GO:0015297;monoatomic cation transmembrane transporter activity#GO:0008324;potassium ion transmembrane transporter activity#GO:0015079 inorganic ion import across plasma membrane#GO:0099587;homeostatic process#GO:0042592;metal ion transport#GO:0030001;import across plasma membrane#GO:0098739;sodium ion transport#GO:0006814;intracellular monoatomic ion homeostasis#GO:0006873;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;regulation of intracellular pH#GO:0051453;regulation of pH#GO:0006885;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;potassium ion transport#GO:0006813;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;monoatomic ion homeostasis#GO:0050801;inorganic cation import across plasma membrane#GO:0098659;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;establishment of localization#GO:0051234;import into cell#GO:0098657;chemical homeostasis#GO:0048878;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;transport#GO:0006810 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 secondary carrier transporter#PC00258 HUMAN|HGNC=26987|UniProtKB=Q7Z2F6 Q7Z2F6 KRABD5 PTHR23232:SF178 KRAB DOMAIN C2H2 ZINC FINGER KRAB DOMAIN-CONTAINING PROTEIN 5-RELATED RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=24327|UniProtKB=A8MV65 A8MV65 VGLL3 PTHR15950:SF16 TRANSCRIPTION COFACTOR VESTIGIAL-LIKE PROTEIN TRANSCRIPTION COFACTOR VESTIGIAL-LIKE PROTEIN 3 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 transcription cofactor#PC00217;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=20422|UniProtKB=P0DPB6 P0DPB6 POLR1D PTHR13946:SF28 DNA-DIRECTED RNA POLYMERASE I,II,III DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2 transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;nucleotidyltransferase activity#GO:0016779;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on RNA#GO:0140098 nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;transcription by RNA polymerase III#GO:0006383;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;DNA-templated transcription elongation#GO:0006354;transcription by RNA polymerase I#GO:0006360;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139 intracellular organelle#GO:0043229;RNA polymerase I complex#GO:0005736;RNA polymerase III complex#GO:0005666;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991 DNA-directed RNA polymerase#PC00019;RNA metabolism protein#PC00031 General transcription by RNA polymerase I#P00022>RNA Polymerase I Complex#P00652 HUMAN|HGNC=24217|UniProtKB=Q86X95 Q86X95 CIRSR PTHR13151:SF2 CBF1 INTERACTING COREPRESSOR CIR COREPRESSOR OF RBPJ AND SPLICING REGULATOR transcription regulator activity#GO:0140110;transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712 negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 Notch signaling pathway#P00045>CoR#P01112 HUMAN|HGNC=11850|UniProtKB=O00206 O00206 TLR4 PTHR24365:SF521 TOLL-LIKE RECEPTOR TOLL-LIKE RECEPTOR 4 lipid binding#GO:0008289;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;pattern recognition receptor activity#GO:0038187;lipopolysaccharide binding#GO:0001530;carbohydrate derivative binding#GO:0097367;binding#GO:0005488 response to lipopolysaccharide#GO:0032496;positive regulation of response to external stimulus#GO:0032103;immune response-activating signaling pathway#GO:0002757;cell surface receptor signaling pathway#GO:0007166;response to lipid#GO:0033993;regulation of response to external stimulus#GO:0032101;response to chemical#GO:0042221;cellular process#GO:0009987;activation of immune response#GO:0002253;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;positive regulation of immune system process#GO:0002684;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;defense response to bacterium#GO:0042742;response to oxygen-containing compound#GO:1901700;immune system process#GO:0002376;biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052;defense response to Gram-negative bacterium#GO:0050829;response to stimulus#GO:0050896;detection of chemical stimulus#GO:0009593;immune response-regulating signaling pathway#GO:0002764;response to molecule of bacterial origin#GO:0002237;regulation of biological process#GO:0050789;toll-like receptor signaling pathway#GO:0002224;defense response#GO:0006952;pattern recognition receptor signaling pathway#GO:0002221;response to external stimulus#GO:0009605;positive regulation of response to biotic stimulus#GO:0002833;regulation of innate immune response#GO:0045088;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;positive regulation of defense response#GO:0031349;regulation of response to stress#GO:0080134;response to other organism#GO:0051707;immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007;toll-like receptor 4 signaling pathway#GO:0034142;positive regulation of response to stimulus#GO:0048584;positive regulation of innate immune response#GO:0045089;activation of innate immune response#GO:0002218;detection of stimulus#GO:0051606;cell communication#GO:0007154;regulation of defense response#GO:0031347;inflammatory response#GO:0006954;regulation of immune response#GO:0050776;response to bacterium#GO:0009617;immune response-activating cell surface receptor signaling pathway#GO:0002429;regulation of response to biotic stimulus#GO:0002831;response to external biotic stimulus#GO:0043207;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;cellular response to stimulus#GO:0051716;innate immune response-activating signaling pathway#GO:0002758 signaling receptor complex#GO:0043235;cell periphery#GO:0071944;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 transmembrane signal receptor#PC00197 Toll receptor signaling pathway#P00054>TLR2,4,7#P01351;Toll receptor signaling pathway#P00054>TLR#P01346;Toll receptor signaling pathway#P00054>TLR4#P01339 HUMAN|HGNC=15584|UniProtKB=Q8IYJ3 Q8IYJ3 SYTL1 PTHR45716:SF3 BITESIZE, ISOFORM I SYNAPTOTAGMIN-LIKE PROTEIN 1 signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515 cellular process#GO:0009987;export from cell#GO:0140352;vesicle-mediated transport#GO:0016192;transport#GO:0006810;secretion by cell#GO:0032940;exocytosis#GO:0006887;localization#GO:0051179;secretion#GO:0046903;establishment of localization#GO:0051234 cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular vesicle#GO:0097708;cytoplasm#GO:0005737;plasma membrane#GO:0005886;endomembrane system#GO:0012505;transport vesicle#GO:0030133;cell periphery#GO:0071944;secretory vesicle#GO:0099503;membrane#GO:0016020 membrane trafficking regulatory protein#PC00151;membrane traffic protein#PC00150 HUMAN|HGNC=33788|UniProtKB=Q6NUJ2 Q6NUJ2 C11orf87 PTHR31870:SF2 SI:DKEY-183I3.9-RELATED CHROMOSOME 11 OPEN READING FRAME 87 HUMAN|HGNC=25874|UniProtKB=Q9H3U5 Q9H3U5 MFSD1 PTHR23512:SF13 MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1 LYSOSOMAL DIPEPTIDE TRANSPORTER MFSD1 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;lytic vacuole#GO:0000323;lysosome#GO:0005764;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;vacuole#GO:0005773;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=4595|UniProtKB=Q14832 Q14832 GRM3 PTHR24060:SF160 METABOTROPIC GLUTAMATE RECEPTOR METABOTROPIC GLUTAMATE RECEPTOR 3 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888;adenylate cyclase inhibiting G protein-coupled glutamate receptor activity#GO:0001640;glutamate receptor activity#GO:0008066 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;modulation of chemical synaptic transmission#GO:0050804;signaling#GO:0023052;regulation of cell communication#GO:0010646;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;regulation of synaptic transmission, glutamatergic#GO:0051966;cell communication#GO:0007154;glutamate receptor signaling pathway#GO:0007215;G protein-coupled receptor signaling pathway#GO:0007186;regulation of signaling#GO:0023051;regulation of trans-synaptic signaling#GO:0099177;biological regulation#GO:0065007;signal transduction#GO:0007165;cellular process#GO:0009987;cell surface receptor signaling pathway#GO:0007166 G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GoPCR#P00725;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;Ionotropic glutamate receptor pathway#P00037>mGluR 2/3#P01014;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GqPCR#P00730;Metabotropic glutamate receptor group II pathway#P00040>mGluR2/3#P01048 HUMAN|HGNC=6814|UniProtKB=Q9UJ55 Q9UJ55 MAGEL2 PTHR11736:SF66 MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN MAGE-LIKE PROTEIN 2 negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 scaffold/adaptor protein#PC00226 HUMAN|HGNC=378|UniProtKB=O43823 O43823 AKAP8 PTHR12190:SF6 A-KINASE ANCHOR PROTEIN AKAP 8 A-KINASE ANCHOR PROTEIN 8 binding#GO:0005488;protein kinase A binding#GO:0051018;protein kinase A regulatory subunit binding#GO:0034237;protein binding#GO:0005515 mitotic sister chromatid segregation#GO:0000070;organelle organization#GO:0006996;cellular process#GO:0009987;chromosome segregation#GO:0007059;cellular component organization or biogenesis#GO:0071840;mitotic cell cycle process#GO:1903047;chromosome organization#GO:0051276;cell cycle#GO:0007049;nuclear chromosome segregation#GO:0098813;sister chromatid segregation#GO:0000819;cellular component organization#GO:0016043;cell cycle process#GO:0022402;mitotic nuclear division#GO:0140014;mitotic cell cycle#GO:0000278;nuclear division#GO:0000280;organelle fission#GO:0048285;mitotic chromosome condensation#GO:0007076;chromosome condensation#GO:0030261 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 scaffold/adaptor protein#PC00226 HUMAN|HGNC=19899|UniProtKB=Q9P243 Q9P243 ZFAT PTHR24388:SF73 ZINC FINGER PROTEIN ZINC FINGER PROTEIN ZFAT sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=25593|UniProtKB=Q9H813 Q9H813 PACC1 PTHR16087:SF0 TRANSMEMBRANE PROTEIN 206 PROTON-ACTIVATED CHLORIDE CHANNEL HUMAN|HGNC=24088|UniProtKB=Q9HAU6 Q9HAU6 TPT1P8 PTHR11991:SF9 TRANSLATIONALLY CONTROLLED TUMOR PROTEIN-RELATED TPT1-LIKE PROTEIN-RELATED cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167 regulation of autophagy#GO:0010506;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;negative regulation of metabolic process#GO:0009892;negative regulation of signaling#GO:0023057;regulation of apoptotic signaling pathway#GO:2001233;regulation of signaling#GO:0023051;negative regulation of apoptotic signaling pathway#GO:2001234;negative regulation of cell communication#GO:0010648;negative regulation of catabolic process#GO:0009895;regulation of metabolic process#GO:0019222;negative regulation of programmed cell death#GO:0043069;negative regulation of response to stimulus#GO:0048585;negative regulation of apoptotic process#GO:0043066;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;regulation of apoptotic process#GO:0042981;regulation of response to stimulus#GO:0048583;regulation of catabolic process#GO:0009894;negative regulation of autophagy#GO:0010507 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 microtubule or microtubule-binding cytoskeletal protein#PC00157;cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HUMAN|HGNC=4628|UniProtKB=Q16772 Q16772 GSTA3 PTHR11571:SF257 GLUTATHIONE S-TRANSFERASE GLUTATHIONE S-TRANSFERASE A3 transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;glutathione transferase activity#GO:0004364;transferase activity#GO:0016740;catalytic activity#GO:0003824 modified amino acid metabolic process#GO:0006575;sulfur compound metabolic process#GO:0006790;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to chemical#GO:0042221;response to stimulus#GO:0050896;cellular response to xenobiotic stimulus#GO:0071466;xenobiotic metabolic process#GO:0006805;glutathione metabolic process#GO:0006749;cellular response to chemical stimulus#GO:0070887;response to xenobiotic stimulus#GO:0009410;metabolic process#GO:0008152 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 transferase#PC00220 HUMAN|HGNC=28951|UniProtKB=P42331 P42331 ARHGAP25 PTHR15228:SF20 SPERMATHECAL PHYSIOLOGY VARIANT RHO GTPASE-ACTIVATING PROTEIN 25 enzyme activator activity#GO:0008047;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 establishment of localization#GO:0051234;actin filament organization#GO:0007015;phagocytosis#GO:0006909;negative regulation of cellular process#GO:0048523;transport#GO:0006810;regulation of response to stimulus#GO:0048583;negative regulation of response to stimulus#GO:0048585;membrane organization#GO:0061024;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;localization#GO:0051179;supramolecular fiber organization#GO:0097435;actin filament-based process#GO:0030029;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;cellular component organization or biogenesis#GO:0071840;phagocytosis, engulfment#GO:0006911;import into cell#GO:0098657;regulation of small GTPase mediated signal transduction#GO:0051056;membrane invagination#GO:0010324;cytoskeleton organization#GO:0007010;negative regulation of signal transduction#GO:0009968;organelle organization#GO:0006996;cellular process#GO:0009987;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;endocytosis#GO:0006897;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HUMAN|HGNC=30416|UniProtKB=O14796 O14796 SH2D1B PTHR46051:SF11 SH2 DOMAIN-CONTAINING PROTEIN SH2 DOMAIN-CONTAINING PROTEIN 1B regulation of immune response#GO:0050776;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;regulation of biological process#GO:0050789 HUMAN|HGNC=5879|UniProtKB=P01699 P01699 IGLV1-44 PTHR23267:SF413 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN LAMBDA VARIABLE 1-44-RELATED response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=31684|UniProtKB=O15391 O15391 YY2 PTHR14003:SF17 TRANSCRIPTIONAL REPRESSOR PROTEIN YY TRANSCRIPTION FACTOR YY2 RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;cell development#GO:0048468;cellular response to stress#GO:0033554;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;response to stress#GO:0006950;regulation of metabolic process#GO:0019222;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;DNA damage response#GO:0006974;developmental process#GO:0032502;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 intracellular anatomical structure#GO:0005622;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694;PcG protein complex#GO:0031519 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=1929|UniProtKB=P10645 P10645 CHGA PTHR10583:SF1 CHROMOGRANIN CHROMOGRANIN-A regulation of protein secretion#GO:0050708;response to external biotic stimulus#GO:0043207;regulation of cell communication#GO:0010646;negative regulation of transport#GO:0051051;regulation of cellular process#GO:0050794;response to bacterium#GO:0009617;regulation of establishment of protein localization#GO:0070201;regulation of secretion#GO:0051046;biological regulation#GO:0065007;negative regulation of protein transport#GO:0051224;response to other organism#GO:0051707;negative regulation of cellular process#GO:0048523;response to external stimulus#GO:0009605;defense response#GO:0006952;regulation of biological process#GO:0050789;regulation of hormone levels#GO:0010817;negative regulation of biological process#GO:0048519;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;regulation of protein transport#GO:0051223;defense response to bacterium#GO:0042742;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;regulation of protein localization#GO:0032880;regulation of secretion by cell#GO:1903530;regulation of biological quality#GO:0065008;negative regulation of cell communication#GO:0010648;regulation of hormone secretion#GO:0046883;regulation of insulin secretion#GO:0050796;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;regulation of transport#GO:0051049;regulation of localization#GO:0032879 intracellular organelle#GO:0043229;extracellular region#GO:0005576;membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;vesicle#GO:0031982;intracellular vesicle#GO:0097708;secretory vesicle#GO:0099503;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 CCKR signaling map#P06959>CHGA#G06978;CCKR signaling map#P06959>CHGA#G07271 HUMAN|HGNC=28235|UniProtKB=Q96IU4 Q96IU4 ABHD14B PTHR46197:SF2 PROTEIN ABHD14B-LIKE PROTEIN-LYSINE DEACYLASE ABHD14B-RELATED catalytic activity#GO:0003824;hydrolase activity#GO:0016787 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=11734|UniProtKB=Q9BXU0 Q9BXU0 TEX12 PTHR37349:SF1 TESTIS-EXPRESSED PROTEIN 12 TESTIS-EXPRESSED PROTEIN 12 reproductive process#GO:0022414;cell cycle#GO:0007049;nuclear chromosome segregation#GO:0098813;cellular component organization#GO:0016043;meiotic cell cycle process#GO:1903046;meiosis I#GO:0007127;cell cycle process#GO:0022402;organelle fission#GO:0048285;meiosis I cell cycle process#GO:0061982;nuclear division#GO:0000280;sexual reproduction#GO:0019953;synaptonemal complex assembly#GO:0007130;cellular component assembly#GO:0022607;homologous chromosome pairing at meiosis#GO:0007129;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;homologous chromosome segregation#GO:0045143;cellular component organization or biogenesis#GO:0071840;meiotic nuclear division#GO:0140013;meiotic chromosome segregation#GO:0045132;chromosome organization#GO:0051276;chromosome organization involved in meiotic cell cycle#GO:0070192;meiotic cell cycle#GO:0051321;chromosome segregation#GO:0007059 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;central element#GO:0000801;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;organelle lumen#GO:0043233;chromosome#GO:0005694;membraneless organelle#GO:0043228;synaptonemal complex#GO:0000795;condensed nuclear chromosome#GO:0000794;condensed chromosome#GO:0000793;synaptonemal structure#GO:0099086;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974 HUMAN|HGNC=8191|UniProtKB=Q8WZA6 Q8WZA6 OR1E3 PTHR48001:SF130 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 1E3 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=30036|UniProtKB=Q9HAU0 Q9HAU0 PLEKHA5 PTHR12752:SF3 PHOSPHOINOSITOL 3-PHOSPHATE-BINDING PROTEIN PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 5 phosphatidylinositol phosphate binding#GO:1901981;phosphatidylinositol-3-phosphate binding#GO:0032266;phospholipid binding#GO:0005543;phosphatidylinositol bisphosphate binding#GO:1902936;lipid binding#GO:0008289;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;binding#GO:0005488 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 HUMAN|HGNC=19096|UniProtKB=Q8NDX1 Q8NDX1 PSD4 PTHR10663:SF338 GUANYL-NUCLEOTIDE EXCHANGE FACTOR PH AND SEC7 DOMAIN-CONTAINING PROTEIN 4 ruffle#GO:0001726;cell projection membrane#GO:0031253;ruffle membrane#GO:0032587;leading edge membrane#GO:0031256;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;plasma membrane#GO:0005886;membrane#GO:0016020;cell leading edge#GO:0031252;cell periphery#GO:0071944 guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=24607|UniProtKB=Q86VF2 Q86VF2 IGFN1 PTHR13817:SF138 TITIN IMMUNOGLOBULIN-LIKE AND FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN 1 structural protein#PC00211 HUMAN|HGNC=30951|UniProtKB=Q6ZNG1 Q6ZNG1 ZNF600 PTHR24376:SF85 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 600-RELATED negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=23817|UniProtKB=Q9H9A5 Q9H9A5 CNOT10 PTHR12979:SF5 CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 10 CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 10 nucleic acid catabolic process#GO:0141188;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of translation#GO:0006417;nucleobase-containing compound catabolic process#GO:0034655;regulation of primary metabolic process#GO:0080090;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;negative regulation of protein metabolic process#GO:0051248;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;cellular process#GO:0009987;regulation of protein metabolic process#GO:0051246;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;RNA catabolic process#GO:0006401;negative regulation of translation#GO:0017148;RNA metabolic process#GO:0016070 protein-containing complex#GO:0032991;intracellular protein-containing complex#GO:0140535;CCR4-NOT complex#GO:0030014 HUMAN|HGNC=1977|UniProtKB=Q9UHD4 Q9UHD4 CIDEB PTHR12306:SF10 CELL DEATH ACTIVATOR CIDE LIPID TRANSFERASE CIDEB lipid transfer activity#GO:0120013;lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104;transporter activity#GO:0005215 cellular component organization or biogenesis#GO:0071840;lipid droplet organization#GO:0034389;organelle fusion#GO:0048284;lipid storage#GO:0019915;cellular process#GO:0009987;cell death#GO:0008219;apoptotic process#GO:0006915;organelle organization#GO:0006996;cellular component organization#GO:0016043;programmed cell death#GO:0012501 cellular anatomical structure#GO:0110165;membraneless organelle#GO:0043228;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;lipid droplet#GO:0005811;intracellular membraneless organelle#GO:0043232;intracellular organelle#GO:0043229 HUMAN|HGNC=24892|UniProtKB=Q6P4E1 Q6P4E1 GOLM2 PTHR15896:SF7 GOLGI PHOSPHOPROTEIN 2/GP73-RELATED PROTEIN GOLM2 HUMAN|HGNC=25356|UniProtKB=Q9H040 Q9H040 SPRTN PTHR21220:SF0 DNA-DEPENDENT METALLOPROTEASE SPRTN DNA-DEPENDENT METALLOPROTEASE SPRTN endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;nucleobase-containing compound biosynthetic process#GO:0034654;DNA damage response#GO:0006974;DNA damage tolerance#GO:0006301;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;translesion synthesis#GO:0019985;response to stress#GO:0006950;DNA biosynthetic process#GO:0071897;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;DNA synthesis involved in DNA replication#GO:0090592;nucleic acid biosynthetic process#GO:0141187;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;DNA replication#GO:0006260;cellular response to stimulus#GO:0051716 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=4184|UniProtKB=Q9H0R5 Q9H0R5 GBP3 PTHR10751:SF146 GUANYLATE BINDING PROTEIN GUANYLATE-BINDING PROTEIN 3 hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787 membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708 G-protein#PC00020;heterotrimeric G-protein#PC00117 HUMAN|HGNC=6164|UniProtKB=O95965 O95965 ITGBL1 PTHR10082:SF3 INTEGRIN BETA SUBUNIT INTEGRIN BETA-LIKE PROTEIN 1 signaling receptor binding#GO:0005102;binding#GO:0005488;cell adhesion molecule binding#GO:0050839;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;integrin binding#GO:0005178 cell-cell adhesion#GO:0098609;cellular process#GO:0009987;signal transduction#GO:0007165;cell migration#GO:0016477;biological regulation#GO:0065007;cell surface receptor signaling pathway#GO:0007166;cell adhesion mediated by integrin#GO:0033627;integrin-mediated signaling pathway#GO:0007229;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cell motility#GO:0048870;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;cell adhesion#GO:0007155;cell-matrix adhesion#GO:0007160;cell communication#GO:0007154;cell-substrate adhesion#GO:0031589 signaling receptor complex#GO:0043235;integrin complex#GO:0008305;cell junction#GO:0030054;anchoring junction#GO:0070161;membrane#GO:0016020;membrane protein complex#GO:0098796;protein complex involved in cell adhesion#GO:0098636;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cell surface#GO:0009986;plasma membrane#GO:0005886;cell-substrate junction#GO:0030055;focal adhesion#GO:0005925 integrin#PC00126 Integrin signalling pathway#P00034>Integrin beta#P00931 HUMAN|HGNC=30892|UniProtKB=Q7Z6Z7 Q7Z6Z7 HUWE1 PTHR11254:SF446 HECT DOMAIN UBIQUITIN-PROTEIN LIGASE E3 UBIQUITIN-PROTEIN LIGASE HUWE1 ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824 ubiquitin-dependent protein catabolic process#GO:0006511;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;DNA repair#GO:0006281;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;DNA metabolic process#GO:0006259;membrane organization#GO:0061024;nucleobase-containing compound metabolic process#GO:0006139;endomembrane system organization#GO:0010256;cellular process#GO:0009987;organelle organization#GO:0006996;membrane fusion#GO:0061025;response to stress#GO:0006950;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;modification-dependent macromolecule catabolic process#GO:0043632;response to stimulus#GO:0050896;catabolic process#GO:0009056;Golgi organization#GO:0007030;modification-dependent protein catabolic process#GO:0019941;cellular response to stimulus#GO:0051716;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;base-excision repair#GO:0006284 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;nucleus#GO:0005634;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=3402|UniProtKB=P34913 P34913 EPHX2 PTHR43329:SF165 EPOXIDE HYDROLASE BIFUNCTIONAL EPOXIDE HYDROLASE 2 hydrolase activity#GO:0016787;catalytic activity#GO:0003824 dephosphorylation#GO:0016311;lipid modification#GO:0030258;cholesterol homeostasis#GO:0042632;chemical homeostasis#GO:0048878;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;homeostatic process#GO:0042592;phospholipid dephosphorylation#GO:0046839;phosphate-containing compound metabolic process#GO:0006796;cellular process#GO:0009987;primary metabolic process#GO:0044238;lipid homeostasis#GO:0055088 microbody#GO:0042579;peroxisome#GO:0005777;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 hydrolase#PC00121 HUMAN|HGNC=33910|UniProtKB=Q9UH36 Q9UH36 SRRD PTHR28626:SF3 SRR1-LIKE PROTEIN SRR1-LIKE PROTEIN intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=16832|UniProtKB=Q16864 Q16864 ATP6V1F PTHR13861:SF2 VACUOLAR ATP SYNTHASE SUBUNIT F V-TYPE PROTON ATPASE SUBUNIT F cellular anatomical structure#GO:0110165;membrane#GO:0016020 primary active transporter#PC00068;ATP synthase#PC00002 HUMAN|HGNC=11135|UniProtKB=Q13487 Q13487 SNAPC2 PTHR15132:SF1 SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 2 SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 2 cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear body#GO:0016604;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 HUMAN|HGNC=14932|UniProtKB=Q9Y6E7 Q9Y6E7 SIRT4 PTHR11085:SF20 NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED NAD-DEPENDENT PROTEIN LIPOAMIDASE SIRTUIN-4, MITOCHONDRIAL acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;NAD-dependent protein lysine deacetylase activity#GO:0034979;glycosyltransferase activity#GO:0016757;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;deacylase activity#GO:0160215;histone deacetylase activity#GO:0004407;catalytic activity#GO:0003824;histone modifying activity#GO:0140993;deacetylase activity#GO:0019213;pentosyltransferase activity#GO:0016763;acyltransferase activity#GO:0016746;NAD+ poly-ADP-ribosyltransferase activity#GO:0003950 nucleus#GO:0005634;mitochondrion#GO:0005739;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=26111|UniProtKB=Q0P651 Q0P651 ABHD18 PTHR13617:SF14 PROTEIN ABHD18 CARDIOLIPIN-SPECIFIC DEACYLASE, MITOCHONDRIAL phospholipase activity#GO:0120569;hydrolase activity, acting on ester bonds#GO:0016788;glycerophospholipase activity#GO:0004620;catalytic activity#GO:0003824;lipase activity#GO:0016298;hydrolase activity#GO:0016787 phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;glycerolipid metabolic process#GO:0046486;glycerophospholipid metabolic process#GO:0006650;phosphatidylglycerol metabolic process#GO:0046471;phospholipid metabolic process#GO:0006644;metabolic process#GO:0008152;lipid metabolic process#GO:0006629 HUMAN|HGNC=20614|UniProtKB=Q8NAT2 Q8NAT2 TDRD5 PTHR22948:SF29 TUDOR DOMAIN CONTAINING PROTEIN TUDOR DOMAIN-CONTAINING PROTEIN 5 scaffold/adaptor protein#PC00226 HUMAN|HGNC=32388|UniProtKB=A6NDD5 A6NDD5 SYNDIG1L PTHR14768:SF4 UPF0338 PROTEIN SYNAPSE DIFFERENTIATION-INDUCING GENE PROTEIN 1-LIKE intracellular organelle#GO:0043229;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=4653|UniProtKB=P13984 P13984 GTF2F2 PTHR10445:SF0 GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2 GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;transcription initiation at RNA polymerase II promoter#GO:0006367;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;DNA-templated transcription initiation#GO:0006352;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070 protein-containing complex#GO:0032991;RNA polymerase II transcription regulator complex#GO:0090575;membrane-enclosed lumen#GO:0031974;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;transcription regulator complex#GO:0005667;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;RNA polymerase II, holoenzyme#GO:0016591;membrane-bounded organelle#GO:0043227;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 general transcription factor#PC00259;RNA metabolism protein#PC00031 General transcription regulation#P00023>TFIIFbeta#P00667;Transcription regulation by bZIP transcription factor#P00055>TFIIFbeta#P01396 HUMAN|HGNC=13096|UniProtKB=Q06730 Q06730 ZNF33A PTHR24376:SF259 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 33A regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=49420|UniProtKB=E9PI22 E9PI22 PRR23D1 PTHR31813:SF3 PROLINE-RICH PROTEIN 23B PROLINE-RICH PROTEIN 23D1-RELATED HUMAN|HGNC=6598|UniProtKB=P18858 P18858 LIG1 PTHR45674:SF15 DNA LIGASE 1/3 FAMILY MEMBER DNA LIGASE 1 ligase activity#GO:0016874;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on DNA#GO:0140097 DNA-templated DNA replication#GO:0006261;cell cycle#GO:0007049;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;DNA replication#GO:0006260;cell cycle process#GO:0022402;mitotic cell cycle#GO:0000278;DNA strand elongation involved in DNA replication#GO:0006271;cell cycle DNA replication#GO:0044786;metabolic process#GO:0008152;mitotic DNA replication#GO:1902969;DNA metabolic process#GO:0006259;nuclear DNA replication#GO:0033260;macromolecule metabolic process#GO:0043170;mitotic cell cycle process#GO:1903047;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA metabolism protein#PC00009;DNA ligase#PC00012 HUMAN|HGNC=4764|UniProtKB=P84243 P84243 H3-3A PTHR11426:SF228 HISTONE H3 HISTONE H3.3 cellular component assembly#GO:0022607;chromosome localization#GO:0050000;organelle organization#GO:0006996;mitotic sister chromatid segregation#GO:0000070;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;chromosome organization#GO:0051276;protein-containing complex organization#GO:0043933;mitotic cell cycle process#GO:1903047;metaphase chromosome alignment#GO:0051310;chromosome segregation#GO:0007059;mitotic cell cycle#GO:0000278;membraneless organelle assembly#GO:0140694;sister chromatid segregation#GO:0000819;nuclear chromosome segregation#GO:0098813;cellular component organization#GO:0016043;cell cycle#GO:0007049;mitotic nuclear division#GO:0140014;cell cycle process#GO:0022402;protein-containing complex assembly#GO:0065003;mitotic metaphase chromosome alignment#GO:0007080;organelle fission#GO:0048285;localization#GO:0051179;kinetochore organization#GO:0051383;organelle localization#GO:0051640;nuclear division#GO:0000280;organelle assembly#GO:0070925;kinetochore assembly#GO:0051382 chromatin/chromatin-binding, or -regulatory protein#PC00077 DNA replication#P00017>Histones#P00527 HUMAN|HGNC=31253|UniProtKB=Q8NH02 Q8NH02 OR2T29 PTHR26453:SF161 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2T29-RELATED signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 response to stimulus#GO:0050896;response to chemical#GO:0042221;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;detection of chemical stimulus#GO:0009593;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;system process#GO:0003008;sensory perception#GO:0007600;nervous system process#GO:0050877;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=4067|UniProtKB=O95166 O95166 GABARAP PTHR10969:SF20 MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED GAMMA-AMINOBUTYRIC ACID RECEPTOR-ASSOCIATED PROTEIN ubiquitin protein ligase binding#GO:0031625;ubiquitin-like protein ligase binding#GO:0044389;phospholipid binding#GO:0005543;GABA receptor binding#GO:0050811;lipid binding#GO:0008289;protein binding#GO:0005515;enzyme binding#GO:0019899;signaling receptor binding#GO:0005102;binding#GO:0005488 cellular component assembly#GO:0022607;macroautophagy#GO:0016236;response to stress#GO:0006950;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;response to nutrient levels#GO:0031667;autophagosome organization#GO:1905037;cellular process#GO:0009987;autophagy#GO:0006914;cellular component organization or biogenesis#GO:0071840;mitophagy#GO:0000423;protein-containing complex organization#GO:0043933;autophagosome assembly#GO:0000045;autophagy of mitochondrion#GO:0000422;autophagosome maturation#GO:0097352;metabolic process#GO:0008152;cellular response to starvation#GO:0009267;cellular response to nutrient levels#GO:0031669;response to stimulus#GO:0050896;catabolic process#GO:0009056;protein-containing complex disassembly#GO:0032984;cellular component organization#GO:0016043;response to starvation#GO:0042594;cellular response to stimulus#GO:0051716;cellular component disassembly#GO:0022411;process utilizing autophagic mechanism#GO:0061919;vacuole organization#GO:0007033;organelle assembly#GO:0070925;cellular response to stress#GO:0033554 autophagosome#GO:0005776;intracellular organelle#GO:0043229;vacuolar membrane#GO:0005774;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;autophagosome membrane#GO:0000421;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;vacuole#GO:0005773 microtubule or microtubule-binding cytoskeletal protein#PC00157;cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HUMAN|HGNC=3718|UniProtKB=P26885 P26885 FKBP2 PTHR45779:SF3 PEPTIDYLPROLYL ISOMERASE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP2 catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;cis-trans isomerase activity#GO:0016859;peptidyl-prolyl cis-trans isomerase activity#GO:0003755;isomerase activity#GO:0016853 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 TGF-beta signaling pathway#P00052>FKBP12#P01288 HUMAN|HGNC=1029|UniProtKB=P46663 P46663 BDKRB1 PTHR24228:SF28 B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR B1 BRADYKININ RECEPTOR G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;molecular transducer activity#GO:0060089 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GqPCR#P00730 HUMAN|HGNC=12971|UniProtKB=Q2M3W8 Q2M3W8 ZNF181 PTHR24377:SF710 IP01015P-RELATED ZINC FINGER PROTEIN 181-RELATED DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=569|UniProtKB=Q9Y2T2 Q9Y2T2 AP3M1 PTHR10529:SF342 AP COMPLEX SUBUNIT MU AP-3 COMPLEX SUBUNIT MU-1 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;cargo adaptor activity#GO:0140312 postsynaptic neurotransmitter receptor internalization#GO:0098884;endocytosis#GO:0006897;localization#GO:0051179;Golgi to vacuole transport#GO:0006896;cellular localization#GO:0051641;post-Golgi vesicle-mediated transport#GO:0006892;regulation of biological quality#GO:0065008;receptor internalization#GO:0031623;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;biological regulation#GO:0065007;regulation of postsynaptic membrane neurotransmitter receptor levels#GO:0099072;intracellular transport#GO:0046907;vacuolar transport#GO:0007034;Golgi vesicle transport#GO:0048193;transport#GO:0006810;establishment of localization#GO:0051234;import into cell#GO:0098657;vesicle-mediated transport in synapse#GO:0099003;receptor-mediated endocytosis#GO:0006898 membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;coated membrane#GO:0048475;membrane coat#GO:0030117;Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;Golgi apparatus#GO:0005794;AP-type membrane coat adaptor complex#GO:0030119 membrane traffic protein#PC00150 HUMAN|HGNC=10379|UniProtKB=P09001 P09001 MRPL3 PTHR11229:SF13 50S RIBOSOMAL PROTEIN L3 LARGE RIBOSOMAL SUBUNIT PROTEIN UL3M structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrial ribosome#GO:0005761;organellar ribosome#GO:0000313;organelle lumen#GO:0043233;mitochondrion#GO:0005739;ribosome#GO:0005840;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;membraneless organelle#GO:0043228;mitochondrial large ribosomal subunit#GO:0005762;membrane-enclosed lumen#GO:0031974;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737 ribosomal protein#PC00202 HUMAN|HGNC=17787|UniProtKB=O14910 O14910 LIN7A PTHR14063:SF4 PROTEIN LIN-7 HOMOLOG PROTEIN LIN-7 HOMOLOG A protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 regulation of growth#GO:0040008;signal release from synapse#GO:0099643;chemical synaptic transmission#GO:0007268;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;regulation of cell junction assembly#GO:1901888;trans-synaptic signaling#GO:0099537;organelle localization#GO:0051640;signal release#GO:0023061;secretion#GO:0046903;regulation of synapse structure or activity#GO:0050803;cell communication#GO:0007154;localization#GO:0051179;vesicle localization#GO:0051648;neurotransmitter secretion#GO:0007269;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;regulation of synapse assembly#GO:0051963;transport#GO:0006810;establishment of localization#GO:0051234;regulation of biological process#GO:0050789;regulation of cellular component biogenesis#GO:0044087;export from cell#GO:0140352;signaling#GO:0023052;establishment of organelle localization#GO:0051656;regulation of cellular component organization#GO:0051128;regulation of synapse organization#GO:0050807;regulation of biological quality#GO:0065008;secretion by cell#GO:0032940;cellular localization#GO:0051641;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;synaptic vesicle transport#GO:0048489;synaptic signaling#GO:0099536;establishment of vesicle localization#GO:0051650;neurotransmitter transport#GO:0006836;synaptic vesicle localization#GO:0097479 basolateral plasma membrane#GO:0016323;membrane#GO:0016020;cell-cell junction#GO:0005911;basal plasma membrane#GO:0009925;cell periphery#GO:0071944;plasma membrane region#GO:0098590;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;cell junction#GO:0030054;adherens junction#GO:0005912;membrane protein complex#GO:0098796;basal part of cell#GO:0045178;plasma membrane protein complex#GO:0098797;cellular anatomical structure#GO:0110165;synapse#GO:0045202;anchoring junction#GO:0070161 cell junction protein#PC00070 HUMAN|HGNC=7517|UniProtKB=Q6W4X9 Q6W4X9 MUC6 PTHR11339:SF264 EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED MUCIN-6 extracellular matrix structural constituent#GO:0005201;structural molecule activity#GO:0005198 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012 extracellular matrix protein#PC00102 HUMAN|HGNC=8259|UniProtKB=Q9GZK6 Q9GZK6 OR2J1 PTHR26453:SF184 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2J1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 sensory perception#GO:0007600;nervous system process#GO:0050877;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;detection of chemical stimulus#GO:0009593;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;response to chemical#GO:0042221;response to stimulus#GO:0050896;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=6685|UniProtKB=O95237 O95237 LRAT PTHR46678:SF1 LECITHIN RETINOL ACYLTRANSFERASE LECITHIN RETINOL ACYLTRANSFERASE transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 alcohol metabolic process#GO:0006066;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;retinoid metabolic process#GO:0001523;diterpenoid metabolic process#GO:0016101;cellular process#GO:0009987;hormone metabolic process#GO:0042445;biological regulation#GO:0065007;retinol metabolic process#GO:0042572;olefinic compound metabolic process#GO:0120254;terpenoid metabolic process#GO:0006721;isoprenoid metabolic process#GO:0006720;regulation of biological quality#GO:0065008;primary metabolic process#GO:0044238;regulation of hormone levels#GO:0010817;small molecule metabolic process#GO:0044281 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;rough endoplasmic reticulum#GO:0005791;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 transferase#PC00220;acyltransferase#PC00042 HUMAN|HGNC=1674|UniProtKB=P07766 P07766 CD3E PTHR10570:SF9 T-CELL SURFACE GLYCOPROTEIN CD3 GAMMA CHAIN / DELTA CHAIN T-CELL SURFACE GLYCOPROTEIN CD3 EPSILON CHAIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 signaling#GO:0023052;cell development#GO:0048468;cell differentiation#GO:0030154;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;mononuclear cell differentiation#GO:1903131;leukocyte activation#GO:0045321;leukocyte differentiation#GO:0002521;T cell activation#GO:0042110;cell communication#GO:0007154;anatomical structure development#GO:0048856;lymphocyte differentiation#GO:0030098;cell activation#GO:0001775;immune system process#GO:0002376;biological regulation#GO:0065007;T cell differentiation#GO:0030217;hemopoiesis#GO:0030097;lymphocyte activation#GO:0046649;multicellular organismal process#GO:0032501;signal transduction#GO:0007165;cellular process#GO:0009987;cellular developmental process#GO:0048869;developmental process#GO:0032502;cell surface receptor signaling pathway#GO:0007166 side of membrane#GO:0098552;signaling receptor complex#GO:0043235;external side of plasma membrane#GO:0009897;cell surface#GO:0009986;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944 immunoglobulin receptor superfamily#PC00124 T cell activation#P00053>CD3 eta#P01302 HUMAN|HGNC=7459|UniProtKB=P03905 P03905 MT-ND4 PTHR43507:SF20 NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4 NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4 NADH dehydrogenase activity#GO:0003954;small molecule binding#GO:0036094;catalytic activity#GO:0003824;binding#GO:0005488;oxidoreductase activity, acting on NAD(P)H#GO:0016651;oxidoreductase activity#GO:0016491 monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987;proton transmembrane transport#GO:1902600;monoatomic cation transport#GO:0006812;localization#GO:0051179;establishment of localization#GO:0051234;energy derivation by oxidation of organic compounds#GO:0015980;cellular respiration#GO:0045333;transmembrane transport#GO:0055085;aerobic respiration#GO:0009060;monoatomic ion transport#GO:0006811;metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091;transport#GO:0006810 membrane protein complex#GO:0098796;membrane#GO:0016020;oxidoreductase complex#GO:1990204;respiratory chain complex#GO:0098803;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494;respiratory chain complex I#GO:0045271;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351 oxidoreductase#PC00176 HUMAN|HGNC=1486|UniProtKB=O14815 O14815 CAPN9 PTHR10183:SF385 CALPAIN CALPAIN-9 cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;cysteine-type endopeptidase activity#GO:0004197;endopeptidase activity#GO:0004175 cellular process#GO:0009987;metabolic process#GO:0008152;proteolysis#GO:0006508;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 protease#PC00190;cysteine protease#PC00081 Huntington disease#P00029>Calpain#P00788 HUMAN|HGNC=17809|UniProtKB=Q86US8 Q86US8 SMG6 PTHR15696:SF0 SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7 TELOMERASE-BINDING PROTEIN EST1A DNA binding#GO:0003677;RNA binding#GO:0003723;telomeric repeat DNA binding#GO:0042162;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488 cellular process#GO:0009987;nucleic acid catabolic process#GO:0141188;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleobase-containing compound catabolic process#GO:0034655;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay#GO:0000184;negative regulation of cellular process#GO:0048523;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;macromolecule metabolic process#GO:0043170;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;negative regulation of biological process#GO:0048519;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;RNA catabolic process#GO:0006401;RNA metabolic process#GO:0016070 ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 RNA metabolism protein#PC00031 HUMAN|HGNC=228|UniProtKB=Q9BUB4 Q9BUB4 ADAT1 PTHR46516:SF1 TRNA-SPECIFIC ADENOSINE DEAMINASE 1 TRNA-SPECIFIC ADENOSINE DEAMINASE 1 catalytic activity, acting on a tRNA#GO:0140101;adenosine deaminase activity#GO:0004000;hydrolase activity#GO:0016787;tRNA-specific adenosine deaminase activity#GO:0008251;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;catalytic activity, acting on RNA#GO:0140098;deaminase activity#GO:0019239;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640 nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058 RNA processing factor#PC00147 HUMAN|HGNC=33517|UniProtKB=Q86W11 Q86W11 ZSCAN30 PTHR23226:SF128 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER AND SCAN DOMAIN-CONTAINING PROTEIN 30 DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=9828|UniProtKB=P78406 P78406 RAE1 PTHR10971:SF11 MRNA EXPORT FACTOR AND BUB3 MRNA EXPORT FACTOR RAE1 protein binding#GO:0005515;RNA binding#GO:0003723;ubiquitin binding#GO:0043130;binding#GO:0005488;nucleic acid binding#GO:0003676 RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907;transport#GO:0006810;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;chromosome organization#GO:0051276;nitrogen compound transport#GO:0071705;macromolecule localization#GO:0033036;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;nucleocytoplasmic transport#GO:0006913;nucleic acid transport#GO:0050657;cellular localization#GO:0051641;localization#GO:0051179;nuclear export#GO:0051168;nuclear transport#GO:0051169;cellular component organization#GO:0016043;RNA transport#GO:0050658;transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery#GO:0000972;RNA localization#GO:0006403;nucleobase-containing compound transport#GO:0015931;establishment of RNA localization#GO:0051236 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear pore#GO:0005643;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;organelle envelope#GO:0031967;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;endomembrane system#GO:0012505 RNA metabolism protein#PC00031 HUMAN|HGNC=12201|UniProtKB=A0A0A0MS06 A0A0A0MS06 TRBV23-1 PTHR23268:SF82 T-CELL RECEPTOR BETA CHAIN NON-FUNCTIONAL T CELL RECEPTOR BETA VARIABLE 23-1-RELATED cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=2501|UniProtKB=P32929 P32929 CTH PTHR11808:SF15 TRANS-SULFURATION ENZYME FAMILY MEMBER CYSTATHIONINE GAMMA-LYASE catalytic activity#GO:0003824;heterocyclic compound binding#GO:1901363;small molecule binding#GO:0036094;anion binding#GO:0043168;binding#GO:0005488;ion binding#GO:0043167;carbon-sulfur lyase activity#GO:0016846;lyase activity#GO:0016829 cellular process#GO:0009987;carboxylic acid biosynthetic process#GO:0046394;homocysteine metabolic process#GO:0050667;sulfur compound metabolic process#GO:0006790;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;small molecule metabolic process#GO:0044281;proteinogenic amino acid metabolic process#GO:0170039;small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;amino acid biosynthetic process#GO:0008652;proteinogenic amino acid biosynthetic process#GO:0170038 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;lyase#PC00144 Methionine biosynthesis#P02753>O-Succinyl homoserine lyase#P03026 HUMAN|HGNC=885|UniProtKB=O75882 O75882 ATRN PTHR46376:SF3 LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1 ATTRACTIN cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 DNA-binding transcription factor#PC00218;basic leucine zipper transcription factor#PC00056 HUMAN|HGNC=4612|UniProtKB=P56915 P56915 GSC PTHR46643:SF2 HOMEOBOX PROTEIN GOOSECOID-RELATED HOMEOBOX PROTEIN GOOSECOID sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 HUMAN|HGNC=29032|UniProtKB=O43304 O43304 SEC14L5 PTHR23324:SF39 SEC14 RELATED PROTEIN SEC14-LIKE PROTEIN 5 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 transfer/carrier protein#PC00219 HUMAN|HGNC=22918|UniProtKB=Q9H5J0 Q9H5J0 ZBTB3 PTHR24394:SF19 ZINC FINGER PROTEIN ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 3 DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HUMAN|HGNC=20851|UniProtKB=Q5T0N5 Q5T0N5 FNBP1L PTHR15735:SF14 FCH AND DOUBLE SH3 DOMAINS PROTEIN FORMIN-BINDING PROTEIN 1-LIKE regulation of actin filament-based process#GO:0032970;transport#GO:0006810;membrane invagination#GO:0010324;establishment of localization#GO:0051234;import into cell#GO:0098657;cellular component organization or biogenesis#GO:0071840;receptor-mediated endocytosis#GO:0006898;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;regulation of actin cytoskeleton organization#GO:0032956;membrane organization#GO:0061024;endomembrane system organization#GO:0010256;biological regulation#GO:0065007;localization#GO:0051179;plasma membrane organization#GO:0007009;cellular component organization#GO:0016043;clathrin-dependent endocytosis#GO:0072583;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;endocytosis#GO:0006897;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493 membrane#GO:0016020;intracellular vesicle#GO:0097708;cell periphery#GO:0071944;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;plasma membrane#GO:0005886;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 non-motor actin binding protein#PC00165;cytoskeletal protein#PC00085 HUMAN|HGNC=27291|UniProtKB=Q8IX19 Q8IX19 MCEMP1 PTHR37856:SF1 MAST CELL-EXPRESSED MEMBRANE PROTEIN 1 MAST CELL-EXPRESSED MEMBRANE PROTEIN 1 HUMAN|HGNC=32387|UniProtKB=I3L3L1 I3L3L1 ARL17B PTHR11711:SF347 ADP RIBOSYLATION FACTOR-RELATED ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 17 C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED nucleotide binding#GO:0000166;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;ribonucleotide binding#GO:0032553;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;carbohydrate derivative binding#GO:0097367;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;guanyl nucleotide binding#GO:0019001;small molecule binding#GO:0036094;binding#GO:0005488;anion binding#GO:0043168;nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167 vesicle-mediated transport#GO:0016192;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule localization#GO:0033036;intracellular protein localization#GO:0008104;protein transport#GO:0015031;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 G-protein#PC00020 HUMAN|HGNC=16808|UniProtKB=Q8IWV7 Q8IWV7 UBR1 PTHR21497:SF27 UBIQUITIN LIGASE E3 ALPHA-RELATED E3 UBIQUITIN-PROTEIN LIGASE UBR1 ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740 cellular process#GO:0009987;post-translational protein modification#GO:0043687;proteasomal protein catabolic process#GO:0010498;protein ubiquitination#GO:0016567;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;modification-dependent protein catabolic process#GO:0019941;protein modification by small protein conjugation#GO:0032446;primary metabolic process#GO:0044238;protein modification process#GO:0036211;catabolic process#GO:0009056;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;ubiquitin ligase complex#GO:0000151;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;transferase complex#GO:1990234 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=25020|UniProtKB=Q7L1V2 Q7L1V2 MON1B PTHR13027:SF13 SAND PROTEIN-RELATED VACUOLAR FUSION PROTEIN MON1 HOMOLOG B guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular protein-containing complex#GO:0140535;cytoplasm#GO:0005737;late endosome#GO:0005770;guanyl-nucleotide exchange factor complex#GO:0032045;protein-containing complex#GO:0032991;endomembrane system#GO:0012505 HUMAN|HGNC=1148|UniProtKB=O43683 O43683 BUB1 PTHR14030:SF4 MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1 MITOTIC CHECKPOINT SERINE_THREONINE-PROTEIN KINASE BUB1 transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 regulation of organelle organization#GO:0033043;cell cycle process#GO:0022402;negative regulation of mitotic nuclear division#GO:0045839;regulation of biological process#GO:0050789;negative regulation of cell cycle phase transition#GO:1901988;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;regulation of sister chromatid segregation#GO:0033045;regulation of cell cycle#GO:0051726;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular component organization#GO:0051128;negative regulation of mitotic sister chromatid separation#GO:2000816;negative regulation of mitotic cell cycle#GO:0045930;regulation of mitotic cell cycle phase transition#GO:1901990;cellular process#GO:0009987;mitotic spindle assembly checkpoint signaling#GO:0007094;signal transduction#GO:0007165;negative regulation of sister chromatid segregation#GO:0033046;organelle organization#GO:0006996;regulation of cell cycle process#GO:0010564;cell cycle checkpoint signaling#GO:0000075;negative regulation of mitotic cell cycle phase transition#GO:1901991;regulation of chromosome separation#GO:1905818;negative regulation of metaphase/anaphase transition of cell cycle#GO:1902100;negative regulation of mitotic sister chromatid segregation#GO:0033048;regulation of chromosome segregation#GO:0051983;negative regulation of chromosome segregation#GO:0051985;meiotic sister chromatid cohesion#GO:0051177;cellular component organization or biogenesis#GO:0071840;negative regulation of cell cycle#GO:0045786;negative regulation of mitotic metaphase/anaphase transition#GO:0045841;cellular response to stimulus#GO:0051716;negative regulation of organelle organization#GO:0010639;negative regulation of cellular component organization#GO:0051129;regulation of cell cycle phase transition#GO:1901987;cell cycle#GO:0007049;mitotic cell cycle checkpoint signaling#GO:0007093;regulation of cellular process#GO:0050794;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;mitotic cell cycle#GO:0000278;negative regulation of chromosome organization#GO:2001251;intracellular signal transduction#GO:0035556;regulation of mitotic sister chromatid segregation#GO:0033047;sister chromatid cohesion#GO:0007062;cell communication#GO:0007154;regulation of mitotic cell cycle#GO:0007346;negative regulation of nuclear division#GO:0051784;regulation of nuclear division#GO:0051783;biological regulation#GO:0065007;regulation of mitotic metaphase/anaphase transition#GO:0030071;negative regulation of cell cycle process#GO:0010948;regulation of chromosome organization#GO:0033044;negative regulation of cellular process#GO:0048523;chromosome organization#GO:0051276;mitotic cell cycle process#GO:1903047;regulation of mitotic nuclear division#GO:0007088;negative regulation of chromosome separation#GO:1905819;regulation of mitotic sister chromatid separation#GO:0010965 chromosome#GO:0005694;condensed chromosome, centromeric region#GO:0000779;kinetochore#GO:0000776;cellular anatomical structure#GO:0110165;supramolecular complex#GO:0099080;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;chromosome, centromeric region#GO:0000775;condensed chromosome#GO:0000793;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=26575|UniProtKB=Q96LW4 Q96LW4 PRIMPOL PTHR31399:SF0 DNA-DIRECTED PRIMASE / POLYMERASE PROTEIN DNA-DIRECTED PRIMASE_POLYMERASE PROTEIN DNA-directed DNA polymerase activity#GO:0003887;binding#GO:0005488;chromatin binding#GO:0003682;DNA polymerase activity#GO:0034061;catalytic activity, acting on DNA#GO:0140097;catalytic activity, acting on RNA#GO:0140098;catalytic activity#GO:0003824;transferase activity#GO:0016740;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772 nucleic acid biosynthetic process#GO:0141187;cellular response to stress#GO:0033554;DNA synthesis involved in DNA replication#GO:0090592;DNA-templated DNA replication#GO:0006261;mitochondrial DNA metabolic process#GO:0032042;DNA replication#GO:0006260;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;response to abiotic stimulus#GO:0009628;response to stimulus#GO:0050896;response to light stimulus#GO:0009416;DNA damage tolerance#GO:0006301;DNA damage response#GO:0006974;response to UV#GO:0009411;nucleobase-containing compound biosynthetic process#GO:0034654;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;response to radiation#GO:0009314;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;DNA biosynthetic process#GO:0071897;response to stress#GO:0006950;replication fork processing#GO:0031297;translesion synthesis#GO:0019985;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229 DNA metabolism protein#PC00009 HUMAN|HGNC=4081|UniProtKB=P18505 P18505 GABRB1 PTHR18945:SF429 NEUROTRANSMITTER GATED ION CHANNEL GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-1 transmembrane transporter activity#GO:0022857;ligand-gated channel activity#GO:0022834;chloride transmembrane transporter activity#GO:0015108;passive transmembrane transporter activity#GO:0022803;ligand-gated monoatomic ion channel activity#GO:0015276;channel activity#GO:0015267;monoatomic anion channel activity#GO:0005253;molecular transducer activity#GO:0060089;monoatomic anion transmembrane transporter activity#GO:0008509;transporter activity#GO:0005215;chloride channel activity#GO:0005254;neurotransmitter receptor activity#GO:0030594;signaling receptor activity#GO:0038023;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;transmembrane signaling receptor activity#GO:0004888;gated channel activity#GO:0022836 synaptic signaling#GO:0099536;cellular process#GO:0009987;monoatomic anion transmembrane transport#GO:0098656;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;chloride transport#GO:0006821;transport#GO:0006810;establishment of localization#GO:0051234;monoatomic anion transport#GO:0006820;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;anterograde trans-synaptic signaling#GO:0098916;signaling#GO:0023052;trans-synaptic signaling#GO:0099537;chloride transmembrane transport#GO:1902476;cell communication#GO:0007154;localization#GO:0051179;transmembrane transport#GO:0055085;inorganic anion transport#GO:0015698;monoatomic ion transport#GO:0006811 GABA-ergic synapse#GO:0098982;plasma membrane#GO:0005886;synapse#GO:0045202;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane region#GO:0098590;cell periphery#GO:0071944;membrane#GO:0016020;postsynapse#GO:0098794;cell junction#GO:0030054;signaling receptor complex#GO:0043235;synaptic membrane#GO:0097060;postsynaptic membrane#GO:0045211 ligand-gated ion channel#PC00141 HUMAN|HGNC=2894|UniProtKB=Q9UBT3 Q9UBT3 DKK4 PTHR12113:SF10 DICKKOPF3-LIKE 3 DICKKOPF-RELATED PROTEIN 4 protein binding#GO:0005515;molecular function inhibitor activity#GO:0140678;molecular function regulator activity#GO:0098772;signaling receptor inhibitor activity#GO:0030547;signaling receptor regulator activity#GO:0030545;binding#GO:0005488 regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;negative regulation of Wnt signaling pathway#GO:0030178;negative regulation of response to stimulus#GO:0048585;regulation of canonical Wnt signaling pathway#GO:0060828;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;regulation of Wnt signaling pathway#GO:0030111;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of cell communication#GO:0010648;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;negative regulation of canonical Wnt signaling pathway#GO:0090090 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 membrane traffic protein#PC00150;membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=26117|UniProtKB=Q5T447 Q5T447 HECTD3 PTHR46654:SF1 E3 UBIQUITIN-PROTEIN LIGASE HECTD3 E3 UBIQUITIN-PROTEIN LIGASE HECTD3 ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=7219|UniProtKB=Q00013 Q00013 MPP1 PTHR23122:SF37 MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK 55 KDA ERYTHROCYTE MEMBRANE PROTEIN protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488 biological regulation#GO:0065007;regulation of trans-synaptic signaling#GO:0099177;macromolecule localization#GO:0033036;regulation of transport#GO:0051049;intracellular protein localization#GO:0008104;regulation of localization#GO:0032879;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of neurotransmitter secretion#GO:0046928;regulation of biological process#GO:0050789;regulation of secretion by cell#GO:1903530;localization#GO:0051179;regulation of secretion#GO:0051046;regulation of signaling#GO:0023051;regulation of neurotransmitter transport#GO:0051588 plasma membrane#GO:0005886;anchoring junction#GO:0070161;cell junction#GO:0030054;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;cell-cell junction#GO:0005911 scaffold/adaptor protein#PC00226 HUMAN|HGNC=4814|UniProtKB=O60229 O60229 KALRN PTHR22826:SF49 RHO GUANINE EXCHANGE FACTOR-RELATED KALIRIN guanyl-nucleotide exchange factor activity#GO:0005085;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772 nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;cellular process#GO:0009987;signal transduction#GO:0007165;neuron projection development#GO:0031175;cell projection morphogenesis#GO:0048858;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;cell development#GO:0048468;signaling#GO:0023052;cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;cell differentiation#GO:0030154;response to stimulus#GO:0050896;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;axonogenesis#GO:0007409;neuron development#GO:0048666;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;axon guidance#GO:0007411;axon development#GO:0061564;neurogenesis#GO:0022008;neuron projection guidance#GO:0097485;cellular developmental process#GO:0048869;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;intracellular signal transduction#GO:0035556;system development#GO:0048731;anatomical structure development#GO:0048856;cell communication#GO:0007154 membrane#GO:0016020;postsynapse#GO:0098794;cytoplasm#GO:0005737;asymmetric synapse#GO:0032279;organelle#GO:0043226;postsynaptic specialization#GO:0099572;synapse#GO:0045202;neuron to neuron synapse#GO:0098984;cellular anatomical structure#GO:0110165;postsynaptic density#GO:0014069;intracellular anatomical structure#GO:0005622;extrinsic component of membrane#GO:0019898;cell junction#GO:0030054 protein-binding activity modulator#PC00095;guanyl-nucleotide exchange factor#PC00113 Huntington disease#P00029>Duo#P00773 HUMAN|HGNC=12894|UniProtKB=Q8NC26 Q8NC26 ZNF114 PTHR24384:SF6 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED ZINC FINGER PROTEIN 114 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA-binding transcription factor#PC00218 HUMAN|HGNC=125|UniProtKB=P15309 P15309 ACP3 PTHR11567:SF221 ACID PHOSPHATASE-RELATED PROSTATIC ACID PHOSPHATASE phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;acid phosphatase activity#GO:0003993 regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of cell communication#GO:0010646;regulation of system process#GO:0044057;regulation of G protein-coupled receptor signaling pathway#GO:0008277;regulation of response to stimulus#GO:0048583;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of response to stimulus#GO:0048584;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 phosphatase#PC00181 HUMAN|HGNC=14992|UniProtKB=Q5JRS4 Q5JRS4 OR10J3 PTHR26451:SF28 G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN OLFACTORY RECEPTOR 10J3 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;binding#GO:0005488;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 response to stimulus#GO:0050896;response to chemical#GO:0042221;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;detection of chemical stimulus#GO:0009593;system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception#GO:0007600;nervous system process#GO:0050877 membrane#GO:0016020;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021 HUMAN|HGNC=7159|UniProtKB=P45452 P45452 MMP13 PTHR10201:SF165 MATRIX METALLOPROTEINASE COLLAGENASE 3 metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 metabolic process#GO:0008152;extracellular structure organization#GO:0043062;external encapsulating structure organization#GO:0045229;cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;cellular process#GO:0009987;cellular component organization#GO:0016043;catabolic process#GO:0009056 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 metalloprotease#PC00153 Alzheimer disease-presenilin pathway#P00004>Matrix metalloprotease#P00130;Plasminogen activating cascade#P00050>pro-MMP-13#P01254;Plasminogen activating cascade#P00050>MMP-13#P01250 HUMAN|HGNC=7894|UniProtKB=Q99742 Q99742 NPAS1 PTHR23043:SF25 HYPOXIA-INDUCIBLE FACTOR 1 ALPHA NEURONAL PAS DOMAIN-CONTAINING PROTEIN 1 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=26159|UniProtKB=A4D0V7 A4D0V7 CPED1 PTHR14776:SF1 CADHERIN-LIKE AND PC-ESTERASE DOMAIN-CONTAINING PROTEIN 1 CADHERIN-LIKE AND PC-ESTERASE DOMAIN-CONTAINING PROTEIN 1 HUMAN|HGNC=23140|UniProtKB=Q8NI99 Q8NI99 ANGPTL6 PTHR19143:SF209 FIBRINOGEN/TENASCIN/ANGIOPOEITIN ANGIOPOIETIN-RELATED PROTEIN 6 binding#GO:0005488;signaling receptor binding#GO:0005102;protein binding#GO:0005515 cellular anatomical structure#GO:0110165;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HUMAN|HGNC=14048|UniProtKB=Q9Y3D3 Q9Y3D3 MRPS16 PTHR12919:SF41 30S RIBOSOMAL PROTEIN S16 SMALL RIBOSOMAL SUBUNIT PROTEIN BS16M structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 mitochondrial matrix#GO:0005759;small ribosomal subunit#GO:0015935;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;mitochondrial ribosome#GO:0005761;organellar ribosome#GO:0000313;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ribosome#GO:0005840;mitochondrion#GO:0005739;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrial small ribosomal subunit#GO:0005763;membraneless organelle#GO:0043228;membrane-enclosed lumen#GO:0031974;cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798 ribosomal protein#PC00202 HUMAN|HGNC=25864|UniProtKB=Q53FP2 Q53FP2 TMEM35A PTHR13163:SF0 SPINAL CORD EXPRESSION PROTEIN 4 NOVEL ACETYLCHOLINE RECEPTOR CHAPERONE acetylcholine receptor regulator activity#GO:0030548;signaling receptor regulator activity#GO:0030545;molecular function regulator activity#GO:0098772;neurotransmitter receptor regulator activity#GO:0099602 positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;biological regulation#GO:0065007;cellular component assembly#GO:0022607;chaperone-mediated protein complex assembly#GO:0051131;regulation of localization#GO:0032879;regulation of protein localization#GO:0032880;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=6891|UniProtKB=Q15555 Q15555 MAPRE2 PTHR10623:SF7 MICROTUBULE-ASSOCIATED PROTEIN RP/EB FAMILY MEMBER MICROTUBULE-ASSOCIATED PROTEIN RP_EB FAMILY MEMBER 2 tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;microtubule binding#GO:0008017;protein binding#GO:0005515 localization#GO:0051179;microtubule cytoskeleton organization#GO:0000226;organelle assembly#GO:0070925;regulation of microtubule-based process#GO:0032886;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;protein localization to organelle#GO:0033365;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;cell cycle process#GO:0022402;cell cycle#GO:0007049;membraneless organelle assembly#GO:0140694;protein localization to cytoskeleton#GO:0044380;cellular component organization#GO:0016043;intracellular protein localization#GO:0008104;regulation of microtubule polymerization or depolymerization#GO:0031110;microtubule-based process#GO:0007017;spindle organization#GO:0007051;cellular component organization or biogenesis#GO:0071840;chromosome segregation#GO:0007059;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;regulation of microtubule cytoskeleton organization#GO:0070507;protein localization to microtubule cytoskeleton#GO:0072698;cellular component assembly#GO:0022607;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;macromolecule localization#GO:0033036;organelle organization#GO:0006996;spindle assembly#GO:0051225 organelle#GO:0043226;cellular anatomical structure#GO:0110165;microtubule end#GO:1990752;cytoplasmic microtubule#GO:0005881;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;spindle midzone#GO:0051233;microtubule#GO:0005874;intracellular organelle#GO:0043229;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;microtubule cytoskeleton#GO:0015630;microtubule plus-end#GO:0035371;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;microtubule organizing center#GO:0005815;spindle#GO:0005819;cytoskeleton#GO:0005856 non-motor microtubule binding protein#PC00166;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=17812|UniProtKB=Q9Y2J4 Q9Y2J4 AMOTL2 PTHR14826:SF3 ANGIOMOTIN ANGIOMOTIN-LIKE PROTEIN 2 multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;anatomical structure formation involved in morphogenesis#GO:0048646;vasculature development#GO:0001944;hippo signaling#GO:0035329;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular process#GO:0009987;signal transduction#GO:0007165;angiogenesis#GO:0001525;animal gross anatomical part developmental process#GO:0160108;establishment or maintenance of cell polarity#GO:0007163;response to stimulus#GO:0050896;circulatory system development#GO:0072359;signaling#GO:0023052;cellular component organization#GO:0016043;blood vessel morphogenesis#GO:0048514;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;developmental process#GO:0032502;regulation of cell migration#GO:0030334;multicellular organismal process#GO:0032501;cell migration#GO:0016477;tube development#GO:0035295;regulation of locomotion#GO:0040012;biological regulation#GO:0065007;anatomical structure development#GO:0048856;regulation of cell motility#GO:2000145;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;system development#GO:0048731;actin filament-based process#GO:0030029;actin cytoskeleton organization#GO:0030036;cell motility#GO:0048870;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;tube morphogenesis#GO:0035239;blood vessel development#GO:0001568;establishment of cell polarity#GO:0030010 cytoplasmic vesicle#GO:0031410;anchoring junction#GO:0070161;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;tight junction#GO:0070160;cell junction#GO:0030054;apical junction complex#GO:0043296;bicellular tight junction#GO:0005923;cytoplasm#GO:0005737;plasma membrane#GO:0005886;membrane#GO:0016020;cell-cell junction#GO:0005911;cell periphery#GO:0071944 HUMAN|HGNC=7508|UniProtKB=P15941 P15941 MUC1 PTHR10006:SF19 MUCIN-1-RELATED MUCIN-1 apical part of cell#GO:0045177;cell periphery#GO:0071944;apical plasma membrane#GO:0016324;membrane#GO:0016020;plasma membrane#GO:0005886;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165 cell adhesion molecule#PC00069 HUMAN|HGNC=21175|UniProtKB=A2A288 A2A288 ZC3H12D PTHR12876:SF11 N4BP1-RELATED RIBONUCLEASE ZC3H12D-RELATED catalytic activity, acting on RNA#GO:0140098;RNA endonuclease activity#GO:0004521;RNA nuclease activity#GO:0004540;endonuclease activity#GO:0004519;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;nuclease activity#GO:0004518;RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729 regulation of RNA metabolic process#GO:0051252;regulation of RNA stability#GO:0043487;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of mRNA catabolic process#GO:0061014;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;regulation of biosynthetic process#GO:0009889;positive regulation of catabolic process#GO:0009896;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological quality#GO:0065008;positive regulation of metabolic process#GO:0009893;regulation of mRNA stability#GO:0043488;negative regulation of metabolic process#GO:0009892;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;regulation of mRNA metabolic process#GO:1903311;mRNA destabilization#GO:0061157;positive regulation of mRNA metabolic process#GO:1903313;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;RNA destabilization#GO:0050779;negative regulation of macromolecule biosynthetic process#GO:0010558 nucleus#GO:0005634;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;organelle#GO:0043226;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 endoribonuclease#PC00094 HUMAN|HGNC=53820|UniProtKB=A0A0U1RQG5 A0A0U1RQG5 CT47C1 PTHR32157:SF0 GENE 6268-RELATED CANCER_TESTIS ANTIGEN FAMILY 47 MEMBER C1 HUMAN|HGNC=25071|UniProtKB=Q6IBW4 Q6IBW4 NCAPH2 PTHR14324:SF3 CONDENSIN-2 COMPLEX SUBUNIT H2 CONDENSIN-2 COMPLEX SUBUNIT H2 chromatin binding#GO:0003682;binding#GO:0005488 mitotic nuclear division#GO:0140014;cell cycle process#GO:0022402;cell cycle#GO:0007049;meiotic cell cycle process#GO:1903046;sister chromatid segregation#GO:0000819;nuclear chromosome segregation#GO:0098813;cellular component organization#GO:0016043;reproductive process#GO:0022414;mitotic cell cycle#GO:0000278;mitotic sister chromatid separation#GO:0051306;sexual reproduction#GO:0019953;nuclear division#GO:0000280;chromosome condensation#GO:0030261;organelle fission#GO:0048285;cellular process#GO:0009987;mitotic sister chromatid segregation#GO:0000070;organelle organization#GO:0006996;chromosome segregation#GO:0007059;meiotic cell cycle#GO:0051321;chromosome organization involved in meiotic cell cycle#GO:0070192;mitotic cell cycle process#GO:1903047;chromosome organization#GO:0051276;cellular component organization or biogenesis#GO:0071840;chromosome separation#GO:0051304 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694;nucleus#GO:0005634;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;condensin complex#GO:0000796;intracellular organelle#GO:0043229 HUMAN|HGNC=15035|UniProtKB=Q8NGY6 Q8NGY6 OR6N2 PTHR26451:SF972 G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN OLFACTORY RECEPTOR 6N2 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;binding#GO:0005488;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 response to stimulus#GO:0050896;response to chemical#GO:0042221;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;detection of chemical stimulus#GO:0009593;system process#GO:0003008;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;sensory perception#GO:0007600;nervous system process#GO:0050877 cellular anatomical structure#GO:0110165;membrane#GO:0016020 G-protein coupled receptor#PC00021 HUMAN|HGNC=13785|UniProtKB=Q9HD23 Q9HD23 MRS2 PTHR13890:SF0 RNA SPLICING PROTEIN MRS2, MITOCHONDRIAL MAGNESIUM TRANSPORTER MRS2 HOMOLOG, MITOCHONDRIAL transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;magnesium ion transmembrane transporter activity#GO:0015095;metal ion transmembrane transporter activity#GO:0046873;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075 cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;transport#GO:0006810;magnesium ion transport#GO:0015693;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;monoatomic cation transport#GO:0006812 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 RNA splicing factor#PC00148;RNA processing factor#PC00147 HUMAN|HGNC=7029|UniProtKB=P08581 P08581 MET PTHR24416:SF483 TYROSINE-PROTEIN KINASE RECEPTOR HEPATOCYTE GROWTH FACTOR RECEPTOR signaling receptor activity#GO:0038023;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;molecular transducer activity#GO:0060089;transmembrane receptor protein tyrosine kinase activity#GO:0004714;transmembrane signaling receptor activity#GO:0004888 establishment of localization#GO:0051234;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;phagocytosis#GO:0006909;developmental process#GO:0032502;transport#GO:0006810;multicellular organismal process#GO:0032501;cell migration#GO:0016477;biological regulation#GO:0065007;localization#GO:0051179;cell communication#GO:0007154;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;system development#GO:0048731;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of cellular process#GO:0050794;cell motility#GO:0048870;pancreas development#GO:0031016;cellular response to stimulus#GO:0051716;multicellular organism development#GO:0007275;animal organ development#GO:0048513;import into cell#GO:0098657;neuron differentiation#GO:0030182;cell surface receptor signaling pathway#GO:0007166;nervous system development#GO:0007399;signal transduction#GO:0007165;cellular process#GO:0009987;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;response to stimulus#GO:0050896;cell differentiation#GO:0030154;liver development#GO:0001889;endocytosis#GO:0006897;signaling#GO:0023052;regulation of biological process#GO:0050789 signaling receptor complex#GO:0043235;plasma membrane#GO:0005886;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;basal plasma membrane#GO:0009925;cell periphery#GO:0071944;basal part of cell#GO:0045178;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=6890|UniProtKB=Q15691 Q15691 MAPRE1 PTHR10623:SF20 MICROTUBULE-ASSOCIATED PROTEIN RP/EB FAMILY MEMBER MICROTUBULE-ASSOCIATED PROTEIN RP_EB FAMILY MEMBER 1 cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;microtubule binding#GO:0008017;binding#GO:0005488;protein binding#GO:0005515 organelle assembly#GO:0070925;regulation of microtubule-based process#GO:0032886;localization#GO:0051179;microtubule cytoskeleton organization#GO:0000226;cell cycle#GO:0007049;cellular component organization#GO:0016043;protein localization to cytoskeleton#GO:0044380;membraneless organelle assembly#GO:0140694;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;cell cycle process#GO:0022402;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;protein localization to organelle#GO:0033365;regulation of cellular process#GO:0050794;chromosome segregation#GO:0007059;cellular component organization or biogenesis#GO:0071840;spindle organization#GO:0007051;intracellular protein localization#GO:0008104;regulation of microtubule polymerization or depolymerization#GO:0031110;microtubule-based process#GO:0007017;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;macromolecule localization#GO:0033036;spindle assembly#GO:0051225;cellular process#GO:0009987;cellular component assembly#GO:0022607;protein localization to microtubule cytoskeleton#GO:0072698;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;regulation of microtubule cytoskeleton organization#GO:0070507 cellular anatomical structure#GO:0110165;organelle#GO:0043226;microtubule end#GO:1990752;cytoplasmic microtubule#GO:0005881;spindle midzone#GO:0051233;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;microtubule#GO:0005874;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;microtubule plus-end#GO:0035371;cytoskeleton#GO:0005856;spindle#GO:0005819;microtubule organizing center#GO:0005815 non-motor microtubule binding protein#PC00166;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=27638|UniProtKB=Q5VXT5 Q5VXT5 SYPL2 PTHR10306:SF8 SYNAPTOPHYSIN SYNAPTOPHYSIN-LIKE PROTEIN 2 cytoplasmic vesicle membrane#GO:0030659;transport vesicle membrane#GO:0030658;endomembrane system#GO:0012505;transport vesicle#GO:0030133;cytoplasm#GO:0005737;secretory vesicle#GO:0099503;membrane#GO:0016020;vesicle membrane#GO:0012506;presynapse#GO:0098793;cell junction#GO:0030054;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;synaptic vesicle#GO:0008021;synaptic vesicle membrane#GO:0030672;vesicle#GO:0031982;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229 membrane traffic protein#PC00150;membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=14254|UniProtKB=Q9UK39 Q9UK39 NOCT PTHR12121:SF45 CARBON CATABOLITE REPRESSOR PROTEIN 4 NOCTURNIN RNA nuclease activity#GO:0004540;catalytic activity, acting on RNA#GO:0140098;3'-5' exonuclease activity#GO:0008408;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;nuclease activity#GO:0004518;hydrolase activity#GO:0016787;3'-5'-RNA exonuclease activity#GO:0000175;exonuclease activity#GO:0004527 mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;regulation of mRNA stability#GO:0043488;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;positive regulation of metabolic process#GO:0009893;RNA metabolic process#GO:0016070;regulation of biological quality#GO:0065008;RNA catabolic process#GO:0006401;positive regulation of macromolecule metabolic process#GO:0010604;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;RNA destabilization#GO:0050779;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of mRNA metabolic process#GO:1903311;metabolic process#GO:0008152;mRNA destabilization#GO:0061157;macromolecule catabolic process#GO:0009057;positive regulation of mRNA metabolic process#GO:1903313;regulation of macromolecule metabolic process#GO:0060255;nuclear-transcribed mRNA poly(A) tail shortening#GO:0000289;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;positive regulation of mRNA catabolic process#GO:0061014;regulation of RNA metabolic process#GO:0051252;regulation of RNA stability#GO:0043487;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound catabolic process#GO:0034655;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;nucleic acid catabolic process#GO:0141188;macromolecule metabolic process#GO:0043170;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;nuclear-transcribed mRNA catabolic process#GO:0000956;positive regulation of catabolic process#GO:0009896;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 mRNA polyadenylation factor#PC00146 HUMAN|HGNC=3189|UniProtKB=P68104 P68104 EEF1A1 PTHR23115:SF222 TRANSLATION FACTOR ELONGATION FACTOR 1-ALPHA 1-RELATED ribonucleoside triphosphate phosphatase activity#GO:0017111;translation elongation factor activity#GO:0003746;translation factor activity#GO:0180051;hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;translational elongation#GO:0006414;translation#GO:0006412;gene expression#GO:0010467;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 translation factor#PC00223 HUMAN|HGNC=27028|UniProtKB=A4QMS7 A4QMS7 CFAP90 PTHR34444:SF1 LOC361192 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 90 HUMAN|HGNC=10825|UniProtKB=P78314 P78314 SH3BP2 PTHR15126:SF4 SH3-BINDING SH3 DOMAIN-BINDING PROTEIN 2 HUMAN|HGNC=8863|UniProtKB=O15067 O15067 PFAS PTHR10099:SF1 PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE ligase activity, forming carbon-nitrogen bonds#GO:0016879;catalytic activity#GO:0003824;ligase activity#GO:0016874 nucleobase-containing small molecule metabolic process#GO:0055086;nucleoside phosphate biosynthetic process#GO:1901293;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;nucleotide biosynthetic process#GO:0009165;nucleotide metabolic process#GO:0009117;organophosphate biosynthetic process#GO:0090407;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 De novo purine biosynthesis#P02738>Phosphoribosylformylglycinamide synthase#P02898 HUMAN|HGNC=7762|UniProtKB=Q13562 Q13562 NEUROD1 PTHR19290:SF88 BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED NEUROGENIC DIFFERENTIATION FACTOR 1 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell development#GO:0048468;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;positive regulation of macromolecule metabolic process#GO:0010604;nervous system development#GO:0007399;neuron projection development#GO:0031175;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;animal organ development#GO:0048513;positive regulation of transcription by RNA polymerase II#GO:0045944;neuron differentiation#GO:0030182;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biosynthetic process#GO:0009891;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;multicellular organismal process#GO:0032501;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;plasma membrane bounded cell projection organization#GO:0120036;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;axon development#GO:0061564;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;sensory organ development#GO:0007423;developmental process#GO:0032502 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=16048|UniProtKB=O75474 O75474 FRAT2 PTHR35154:SF2 GBP PROTEIN GSK-3-BINDING PROTEIN FRAT2 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=8905|UniProtKB=P36871 P36871 PGM1 PTHR22573:SF60 PHOSPHOHEXOMUTASE FAMILY MEMBER PHOSPHOGLUCOMUTASE-1 intramolecular phosphotransferase activity#GO:0016868;intramolecular transferase activity#GO:0016866;catalytic activity#GO:0003824;isomerase activity#GO:0016853 cellular process#GO:0009987;primary metabolic process#GO:0044238;metabolic process#GO:0008152;carbohydrate metabolic process#GO:0005975 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 mutase#PC00160;isomerase#PC00135;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=30840|UniProtKB=Q7Z3Y9 Q7Z3Y9 KRT26 PTHR23239:SF162 INTERMEDIATE FILAMENT KERATIN, TYPE I CYTOSKELETAL 26 structural molecule activity#GO:0005198 anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;cell differentiation#GO:0030154;intermediate filament cytoskeleton organization#GO:0045104;intermediate filament organization#GO:0045109;animal gross anatomical part developmental process#GO:0160108;intermediate filament-based process#GO:0045103;supramolecular fiber organization#GO:0097435;anatomical structure development#GO:0048856;tissue morphogenesis#GO:0048729;cellular process#GO:0009987;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;epithelial cell differentiation#GO:0030855;tissue development#GO:0009888;epithelium development#GO:0060429;developmental process#GO:0032502;morphogenesis of an epithelium#GO:0002009;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;intermediate filament#GO:0005882;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;supramolecular complex#GO:0099080;organelle#GO:0043226;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232 intermediate filament#PC00129 HUMAN|HGNC=24726|UniProtKB=Q8N3J2 Q8N3J2 METTL4 PTHR12829:SF9 N6-ADENOSINE-METHYLTRANSFERASE N(6)-ADENINE-SPECIFIC METHYLTRANSFERASE METTL4 catalytic activity, acting on DNA#GO:0140097;catalytic activity, acting on RNA#GO:0140098;RNA methyltransferase activity#GO:0008173;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a nucleic acid#GO:0140640;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 RNA methyltransferase#PC00033 HUMAN|HGNC=19711|UniProtKB=Q96F81 Q96F81 DISP1 PTHR45951:SF4 PROTEIN DISPATCHED-RELATED PROTEIN DISPATCHED HOMOLOG 1 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;smoothened signaling pathway#GO:0007224 membrane#GO:0016020;cellular anatomical structure#GO:0110165 HUMAN|HGNC=32000|UniProtKB=P0DPF2 P0DPF2 NBPF20 PTHR14199:SF35 NEUROBLASTOMA BREAKPOINT FAMILY MEMBER 6-LIKE PROTEIN NBPF FAMILY MEMBER NBPF1-RELATED HUMAN|HGNC=15756|UniProtKB=Q9H190 Q9H190 SDCBP2 PTHR12345:SF13 SYNTENIN RELATED SYNTENIN-2 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 membrane trafficking regulatory protein#PC00151;membrane traffic protein#PC00150 HUMAN|HGNC=34493|UniProtKB=A6NHQ4 A6NHQ4 EPOP PTHR23187:SF1 FLJ44216 PROTEIN-RELATED ELONGIN BC AND POLYCOMB REPRESSIVE COMPLEX 2-ASSOCIATED PROTEIN RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;chromatin remodeling#GO:0006338;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;transcription by RNA polymerase II#GO:0006366;transcription elongation by RNA polymerase II#GO:0006368;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;chromatin organization#GO:0006325;biosynthetic process#GO:0009058;DNA-templated transcription elongation#GO:0006354;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membraneless organelle#GO:0043228;intracellular membraneless organelle#GO:0043232;intracellular anatomical structure#GO:0005622;chromosome#GO:0005694;intracellular organelle#GO:0043229 HUMAN|HGNC=12741|UniProtKB=Q15056 Q15056 EIF4H PTHR23236:SF120 EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H EUKARYOTIC TRANSLATION INITIATION FACTOR 4H nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 HUMAN|HGNC=12230|UniProtKB=A0A0K0K1A5 A0A0K0K1A5 TRBV6-5 PTHR23268:SF19 T-CELL RECEPTOR BETA CHAIN T CELL RECEPTOR BETA VARIABLE 6-2-RELATED response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=14133|UniProtKB=Q9NZV6 Q9NZV6 MSRB1 PTHR46755:SF5 METHIONINE-R-SULFOXIDE REDUCTASE B1 METHIONINE-R-SULFOXIDE REDUCTASE B1 oxidoreductase activity#GO:0016491;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;protein repair#GO:0030091;cellular process#GO:0009987;metabolic process#GO:0008152;primary metabolic process#GO:0044238 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 reductase#PC00198;oxidoreductase#PC00176 HUMAN|HGNC=272|UniProtKB=Q9UGN5 Q9UGN5 PARP2 PTHR10459:SF118 DNA LIGASE POLY [ADP-RIBOSE] POLYMERASE 2 glycosyltransferase activity#GO:0016757;catalytic activity, acting on a protein#GO:0140096;pentosyltransferase activity#GO:0016763;NAD+ poly-ADP-ribosyltransferase activity#GO:0003950;catalytic activity#GO:0003824;transferase activity#GO:0016740 response to stress#GO:0006950;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;double-strand break repair#GO:0006302 intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232 DNA metabolism protein#PC00009 FAS signaling pathway#P00020>PARP#P00600 HUMAN|HGNC=5989|UniProtKB=O95256 O95256 IL18RAP PTHR11890:SF23 INTERLEUKIN-1 RECEPTOR FAMILY MEMBER INTERLEUKIN-18 RECEPTOR ACCESSORY PROTEIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;immune receptor activity#GO:0140375;transmembrane signaling receptor activity#GO:0004888;cytokine receptor activity#GO:0004896 cell communication#GO:0007154;response to peptide#GO:1901652;cytokine-mediated signaling pathway#GO:0019221;cell surface receptor signaling pathway#GO:0007166;regulation of cellular process#GO:0050794;response to chemical#GO:0042221;response to cytokine#GO:0034097;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=9043|UniProtKB=Q9Y263 Q9Y263 PLAA PTHR19849:SF7 PHOSPHOLIPASE A-2-ACTIVATING PROTEIN PHOSPHOLIPASE A-2-ACTIVATING PROTEIN molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 regulation of neuron migration#GO:2001222;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;regulation of cell migration#GO:0030334;macromolecule metabolic process#GO:0043170;positive regulation of locomotion#GO:0040017;ubiquitin-dependent protein catabolic process#GO:0006511;defense response#GO:0006952;positive regulation of cellular process#GO:0048522;positive regulation of cell migration#GO:0030335;biological regulation#GO:0065007;macroautophagy#GO:0016236;regulation of locomotion#GO:0040012;inflammatory response#GO:0006954;regulation of cell motility#GO:2000145;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;regulation of transport#GO:0051049;regulation of localization#GO:0032879;response to stress#GO:0006950;autophagy#GO:0006914;positive regulation of transport#GO:0051050;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;proteasomal protein catabolic process#GO:0010498;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;process utilizing autophagic mechanism#GO:0061919;positive regulation of cell motility#GO:2000147;regulation of biological process#GO:0050789;response to stimulus#GO:0050896 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=33522|UniProtKB=A6NGC4 A6NGC4 TLCD2 PTHR13439:SF2 CT120 PROTEIN TLC DOMAIN-CONTAINING PROTEIN 2 membrane assembly#GO:0071709;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;lipid homeostasis#GO:0055088;biological regulation#GO:0065007;endomembrane system organization#GO:0010256;homeostatic process#GO:0042592;membrane organization#GO:0061024;cellular component assembly#GO:0022607;chemical homeostasis#GO:0048878;regulation of membrane lipid distribution#GO:0097035;regulation of biological quality#GO:0065008;plasma membrane organization#GO:0007009;cellular component organization or biogenesis#GO:0071840 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transferase#PC00220;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=19940|UniProtKB=Q8NBQ7 Q8NBQ7 AQP11 PTHR21191:SF7 AQUAPORIN AQUAPORIN-11 passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;water transmembrane transporter activity#GO:0005372;water channel activity#GO:0015250;channel activity#GO:0015267 chemical homeostasis#GO:0048878;regulation of anatomical structure size#GO:0090066;cellular homeostasis#GO:0019725;regulation of cell size#GO:0008361;regulation of biological quality#GO:0065008;intracellular chemical homeostasis#GO:0055082;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;regulation of cellular component size#GO:0032535;cellular component organization#GO:0016043;biological regulation#GO:0065007;homeostatic process#GO:0042592 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HUMAN|HGNC=11720|UniProtKB=O75443 O75443 TECTA PTHR46160:SF3 ALPHA-TECTORIN-RELATED ALPHA-TECTORIN structural molecule activity#GO:0005198;extracellular matrix structural constituent#GO:0005201 external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|Gene=YA034_HUMAN|UniProtKB=A8MUI8 A8MUI8 PTHR15566:SF10 POM121-LIKE UPF0607 PROTEIN ENSP00000332738-RELATED HUMAN|HGNC=14324|UniProtKB=Q9BXJ1 Q9BXJ1 C1QTNF1 PTHR22923:SF63 CEREBELLIN-RELATED COMPLEMENT C1Q TUMOR NECROSIS FACTOR-RELATED PROTEIN 1 molecular function regulator activity#GO:0098772;molecular function inhibitor activity#GO:0140678 regulation of biological quality#GO:0065008;negative regulation of coagulation#GO:0050819;negative regulation of hemostasis#GO:1900047;regulation of platelet aggregation#GO:0090330;regulation of wound healing#GO:0061041;regulation of body fluid levels#GO:0050878;regulation of blood coagulation#GO:0030193;regulation of cell activation#GO:0050865;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of response to wounding#GO:1903035;regulation of multicellular organismal process#GO:0051239;negative regulation of response to external stimulus#GO:0032102;regulation of response to external stimulus#GO:0032101;negative regulation of cell-cell adhesion#GO:0022408;regulation of response to wounding#GO:1903034;regulation of platelet activation#GO:0010543;regulation of cellular process#GO:0050794;regulation of cell-cell adhesion#GO:0022407;negative regulation of multicellular organismal process#GO:0051241;negative regulation of cell activation#GO:0050866;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;negative regulation of blood coagulation#GO:0030195;regulation of response to stress#GO:0080134;biological regulation#GO:0065007;regulation of cell adhesion#GO:0030155;negative regulation of response to stimulus#GO:0048585;negative regulation of cell adhesion#GO:0007162;regulation of coagulation#GO:0050818;regulation of hemostasis#GO:1900046;negative regulation of wound healing#GO:0061045 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 scaffold/adaptor protein#PC00226 HUMAN|HGNC=1247|UniProtKB=P09871 P09871 C1S PTHR24255:SF18 COMPLEMENT COMPONENT 1, S SUBCOMPONENT-RELATED COMPLEMENT C1S SUBCOMPONENT hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;serine-type peptidase activity#GO:0008236;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity#GO:0003824 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 serine protease#PC00203 HUMAN|HGNC=20373|UniProtKB=Q9NZD8 Q9NZD8 SPG21 PTHR15913:SF1 ACID CLUSTER PROTEIN 33 MASPARDIN binding#GO:0005488;signaling receptor binding#GO:0005102;protein binding#GO:0005515 Golgi-associated vesicle#GO:0005798;clathrin-coated vesicle#GO:0030136;cytoplasm#GO:0005737;transport vesicle#GO:0030133;endomembrane system#GO:0012505;cytosol#GO:0005829;membrane-bounded organelle#GO:0043227;coated vesicle#GO:0030135;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;trans-Golgi network transport vesicle#GO:0030140;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708 HUMAN|HGNC=14436|UniProtKB=Q70E73 Q70E73 RAPH1 PTHR11243:SF15 GROWTH FACTOR RECEPTOR-BOUND PROTEIN RAS-ASSOCIATED AND PLECKSTRIN HOMOLOGY DOMAINS-CONTAINING PROTEIN 1 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;developmental process#GO:0032502;cell projection morphogenesis#GO:0048858;cellular component organization or biogenesis#GO:0071840;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;cellular response to stimulus#GO:0051716;cellular component organization#GO:0016043;signaling#GO:0023052;response to stimulus#GO:0050896;cell projection organization#GO:0030030;cell morphogenesis#GO:0000902;regulation of cellular process#GO:0050794;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;anatomical structure development#GO:0048856 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;cytosol#GO:0005829 scaffold/adaptor protein#PC00226 HUMAN|HGNC=7648|UniProtKB=Q8NFP9 Q8NFP9 NBEA PTHR13743:SF62 BEIGE/BEACH-RELATED NEUROBEACHIN protein binding#GO:0005515;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;kinase binding#GO:0019900;binding#GO:0005488 cellular process#GO:0009987;synapse organization#GO:0050808;cellular component organization#GO:0016043;cell junction organization#GO:0034330;cellular component organization or biogenesis#GO:0071840 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HUMAN|HGNC=2592|UniProtKB=P19099 P19099 CYP11B2 PTHR24279:SF1 CYTOCHROME P450 CYTOCHROME P450 11B2, MITOCHONDRIAL oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;monooxygenase activity#GO:0004497;steroid hydroxylase activity#GO:0008395;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;small molecule metabolic process#GO:0044281;cellular response to hormone stimulus#GO:0032870;secondary alcohol metabolic process#GO:1902652;response to endogenous stimulus#GO:0009719;ketone metabolic process#GO:0042180;regulation of hormone levels#GO:0010817;regulation of biological quality#GO:0065008;cellular response to chemical stimulus#GO:0070887;olefinic compound metabolic process#GO:0120254;response to oxygen-containing compound#GO:1901700;response to chemical#GO:0042221;steroid metabolic process#GO:0008202;response to hormone#GO:0009725;alcohol biosynthetic process#GO:0046165;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987;ketone biosynthetic process#GO:0042181;aldehyde metabolic process#GO:0006081;metabolic process#GO:0008152;alcohol metabolic process#GO:0006066;hormone biosynthetic process#GO:0042446;cellular response to peptide hormone stimulus#GO:0071375;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;response to nitrogen compound#GO:1901698;hormone metabolic process#GO:0042445;cellular response to nitrogen compound#GO:1901699;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058;biological regulation#GO:0065007;response to peptide hormone#GO:0043434;steroid biosynthetic process#GO:0006694;sterol metabolic process#GO:0016125;cholesterol metabolic process#GO:0008203;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrial inner membrane#GO:0005743;organelle envelope#GO:0031967;membrane#GO:0016020;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=23527|UniProtKB=Q8TC84 Q8TC84 FANK1 PTHR24183:SF1 FIBRONECTIN TYPE 3 AND ANKYRIN REPEAT DOMAINS PROTEIN 1 FIBRONECTIN TYPE 3 AND ANKYRIN REPEAT DOMAINS PROTEIN 1 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=4099|UniProtKB=Q6NT46 Q6NT46 GAGE2A PTHR14047:SF30 P ANTIGEN FAMILY MEMBER 5-RELATED G ANTIGEN 1-RELATED HUMAN|HGNC=2879|UniProtKB=Q8WYJ6 Q8WYJ6 SEPTIN1 PTHR18884:SF6 SEPTIN SEPTIN-1 hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides#GO:0016817 regulation of secretion by cell#GO:1903530;regulation of exocytosis#GO:0017157;cytoskeleton-dependent cytokinesis#GO:0061640;localization#GO:0051179;regulation of secretion#GO:0051046;cytokinesis#GO:0000910;regulation of cellular process#GO:0050794;cell cycle process#GO:0022402;cell division#GO:0051301;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;cell cycle#GO:0007049;regulation of localization#GO:0032879;regulation of transport#GO:0051049;intracellular protein localization#GO:0008104;biological regulation#GO:0065007;cellular process#GO:0009987;macromolecule localization#GO:0033036 synaptic vesicle#GO:0008021;cell cortex#GO:0005938;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cell periphery#GO:0071944;presynapse#GO:0098793;secretory vesicle#GO:0099503;microtubule cytoskeleton#GO:0015630;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cell division site#GO:0032153;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;transport vesicle#GO:0030133;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;cell junction#GO:0030054 cytoskeletal protein#PC00085 Parkinson disease#P00049>CDCrel-1#P01226 HUMAN|HGNC=24696|UniProtKB=Q8TER0 Q8TER0 SNED1 PTHR24044:SF411 NOTCH LIGAND FAMILY MEMBER SUSHI, NIDOGEN AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 1 signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515 intercellular signal molecule#PC00207 HUMAN|HGNC=10249|UniProtKB=Q9Y6N7 Q9Y6N7 ROBO1 PTHR12231:SF243 CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN ROUNDABOUT HOMOLOG 1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 anatomical structure development#GO:0048856;axonogenesis#GO:0007409;neuron development#GO:0048666;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;cell recognition#GO:0008037;generation of neurons#GO:0048699;cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell development#GO:0048468;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;neurogenesis#GO:0022008;neuron projection guidance#GO:0097485;cell projection morphogenesis#GO:0048858;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;neuron differentiation#GO:0030182;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cell morphogenesis involved in neuron differentiation#GO:0048667;axon guidance#GO:0007411;axon development#GO:0061564;neuron projection development#GO:0031175;cellular process#GO:0009987 neuron projection membrane#GO:0032589;axon#GO:0030424;leading edge membrane#GO:0031256;cell projection membrane#GO:0031253;membrane#GO:0016020;cell leading edge#GO:0031252;cell periphery#GO:0071944;main axon#GO:0044304;neuron projection#GO:0043005;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;plasma membrane#GO:0005886 immunoglobulin superfamily cell adhesion molecule#PC00125;cell adhesion molecule#PC00069 Axon guidance mediated by Slit/Robo#P00008>Robo#P00348 HUMAN|HGNC=7469|UniProtKB=O75570 O75570 MTRF1 PTHR43804:SF1 LD18447P PEPTIDE CHAIN RELEASE FACTOR 1, MITOCHONDRIAL primary metabolic process#GO:0044238;cellular component organization#GO:0016043;protein biosynthetic process#GO:0160307;mitochondrial translation#GO:0032543;protein-containing complex disassembly#GO:0032984;translational termination#GO:0006415;translation#GO:0006412;cellular component disassembly#GO:0022411;protein metabolic process#GO:0019538;mitochondrial gene expression#GO:0140053;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;biosynthetic process#GO:0009058;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-containing complex organization#GO:0043933 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 translation release factor#PC00225;translation factor#PC00223;translational protein#PC00263 HUMAN|HGNC=26097|UniProtKB=A5D8V6 A5D8V6 VPS37C PTHR13678:SF8 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37C establishment of protein localization to membrane#GO:0090150;protein targeting to vacuole#GO:0006623;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;protein targeting to membrane#GO:0006612;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;intracellular protein transport#GO:0006886;establishment of protein localization to vacuole#GO:0072666;protein targeting#GO:0006605;cellular localization#GO:0051641;protein transport#GO:0015031;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043162;macromolecule localization#GO:0033036;establishment of protein localization to organelle#GO:0072594;macromolecule metabolic process#GO:0043170;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;ubiquitin-dependent protein catabolic process#GO:0006511;intracellular transport#GO:0046907;vacuolar transport#GO:0007034;transport#GO:0006810;catabolic process#GO:0009056;protein localization to organelle#GO:0033365;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;localization#GO:0051179;protein metabolic process#GO:0019538;protein localization to vacuole#GO:0072665;localization within membrane#GO:0051668 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome membrane#GO:0010008;endosome#GO:0005768;cytoplasm#GO:0005737;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;vesicle membrane#GO:0012506;ESCRT I complex#GO:0000813;membrane#GO:0016020;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090 membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=24635|UniProtKB=Q7RTY5 Q7RTY5 PRSS48 PTHR24256:SF309 TRYPTASE-RELATED SERINE PROTEASE 48 catalytic activity#GO:0003824;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;primary metabolic process#GO:0044238;metabolic process#GO:0008152;proteolysis#GO:0006508 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 serine protease#PC00203 HUMAN|HGNC=32327|UniProtKB=Q96LR2 Q96LR2 LURAP1 PTHR33767:SF2 LEUCINE RICH ADAPTOR PROTEIN 1-LIKE LEUCINE RICH ADAPTOR PROTEIN 1 positive regulation of canonical NF-kappaB signal transduction#GO:0043123;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of gene expression#GO:0010628;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of response to stimulus#GO:0048584;regulation of multicellular organismal process#GO:0051239;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of cytokine production#GO:0001817;regulation of canonical NF-kappaB signal transduction#GO:0043122;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of signaling#GO:0023056;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;regulation of cellular process#GO:0050794;positive regulation of cytokine production#GO:0001819;positive regulation of cell communication#GO:0010647;regulation of macromolecule metabolic process#GO:0060255;regulation of cell communication#GO:0010646;positive regulation of signal transduction#GO:0009967;positive regulation of multicellular organismal process#GO:0051240;regulation of biological process#GO:0050789 HUMAN|HGNC=26060|UniProtKB=Q6NUN0 Q6NUN0 ACSM5 PTHR43605:SF6 ACYL-COENZYME A SYNTHETASE ACYL-COENZYME A SYNTHETASE ACSM5, MITOCHONDRIAL acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acyltransferase activity#GO:0016746;ligase activity, forming carbon-sulfur bonds#GO:0016877;catalytic activity#GO:0003824;transferase activity#GO:0016740;ligase activity#GO:0016874;ATP-dependent activity#GO:0140657 carboxylic acid biosynthetic process#GO:0046394;purine-containing compound metabolic process#GO:0072521;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;oxoacid metabolic process#GO:0043436;cellular process#GO:0009987;sulfur compound metabolic process#GO:0006790;organophosphate metabolic process#GO:0019637;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;fatty acid biosynthetic process#GO:0006633;lipid biosynthetic process#GO:0008610;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;acyl-CoA metabolic process#GO:0006637;nucleobase-containing small molecule metabolic process#GO:0055086;monocarboxylic acid biosynthetic process#GO:0072330 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 metabolite interconversion enzyme#PC00262;ligase#PC00142 HUMAN|HGNC=17684|UniProtKB=Q9NVT9 Q9NVT9 ARMC1 PTHR46840:SF1 ARMADILLO REPEAT-CONTAINING PROTEIN 1 ARMADILLO REPEAT-CONTAINING PROTEIN 1 HUMAN|HGNC=15825|UniProtKB=Q9Y2N7 Q9Y2N7 HIF3A PTHR23043:SF18 HYPOXIA-INDUCIBLE FACTOR 1 ALPHA HYPOXIA-INDUCIBLE FACTOR 3-ALPHA sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;response to chemical#GO:0042221;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;response to stress#GO:0006950;regulation of metabolic process#GO:0019222;intracellular chemical homeostasis#GO:0055082;response to hypoxia#GO:0001666;cellular homeostasis#GO:0019725;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;chemical homeostasis#GO:0048878;homeostatic process#GO:0042592;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to decreased oxygen levels#GO:0036293;response to oxygen levels#GO:0070482;cellular response to hypoxia#GO:0071456;response to abiotic stimulus#GO:0009628;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;cellular response to stress#GO:0033554;cellular response to chemical stimulus#GO:0070887 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=10065|UniProtKB=Q9HCM9 Q9HCM9 TRIM39 PTHR24103:SF639 E3 UBIQUITIN-PROTEIN LIGASE TRIM E3 UBIQUITIN-PROTEIN LIGASE TRIM39 ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824 positive regulation of response to stimulus#GO:0048584;response to other organism#GO:0051707;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;immune response#GO:0006955;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;innate immune response#GO:0045087;defense response#GO:0006952;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;response to external stimulus#GO:0009605;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of macromolecule metabolic process#GO:0060255;positive regulation of apoptotic signaling pathway#GO:2001235;negative regulation of protein metabolic process#GO:0051248;regulation of cell communication#GO:0010646;negative regulation of proteasomal protein catabolic process#GO:1901799;response to external biotic stimulus#GO:0043207;positive regulation of signal transduction#GO:0009967;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434;regulation of protein catabolic process#GO:0042176;negative regulation of catabolic process#GO:0009895;regulation of apoptotic signaling pathway#GO:2001233;defense response to other organism#GO:0098542;negative regulation of protein catabolic process#GO:0042177;regulation of proteasomal protein catabolic process#GO:0061136;response to stress#GO:0006950;regulation of protein metabolic process#GO:0051246;response to biotic stimulus#GO:0009607;defense response to symbiont#GO:0140546;regulation of protein stability#GO:0031647;positive regulation of biological process#GO:0048518;positive regulation of apoptotic process#GO:0043065;negative regulation of ubiquitin-dependent protein catabolic process#GO:2000059;protein stabilization#GO:0050821;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;regulation of apoptotic process#GO:0042981;positive regulation of programmed cell death#GO:0043068;negative regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032435;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;regulation of biological process#GO:0050789;positive regulation of signaling#GO:0023056;regulation of biological quality#GO:0065008;immune system process#GO:0002376;regulation of signaling#GO:0023051 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=2296|UniProtKB=P15085 P15085 CPA1 PTHR11705:SF94 PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B CARBOXYPEPTIDASE A1 peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;metalloexopeptidase activity#GO:0008235;catalytic activity#GO:0003824;carboxypeptidase activity#GO:0004180;metallocarboxypeptidase activity#GO:0004181;hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;metallopeptidase activity#GO:0008237 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;cellular process#GO:0009987;metabolic process#GO:0008152;proteolysis#GO:0006508;primary metabolic process#GO:0044238 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 HUMAN|HGNC=49576|UniProtKB=A8MXQ7 A8MXQ7 IQANK1 PTHR46224:SF6 ANKYRIN REPEAT FAMILY PROTEIN IQ MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 1 HUMAN|HGNC=919|UniProtKB=O96024 O96024 B3GALT4 PTHR11214:SF378 BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE BETA-1,3-GALACTOSYLTRANSFERASE 4 glycosyltransferase activity#GO:0016757;transferase activity#GO:0016740;catalytic activity#GO:0003824 organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;membrane#GO:0016020 transferase#PC00220;glycosyltransferase#PC00111 HUMAN|HGNC=6656|UniProtKB=Q9UIQ6 Q9UIQ6 LNPEP PTHR11533:SF42 PROTEASE M1 ZINC METALLOPROTEASE LEUCYL-CYSTINYL AMINOPEPTIDASE metallopeptidase activity#GO:0008237;exopeptidase activity#GO:0008238;hydrolase activity#GO:0016787;metalloaminopeptidase activity#GO:0070006;metalloexopeptidase activity#GO:0008235;catalytic activity#GO:0003824;aminopeptidase activity#GO:0004177;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096 proteolysis#GO:0006508;circulatory system process#GO:0003013;protein metabolic process#GO:0019538;peptide metabolic process#GO:0006518;regulation of biological quality#GO:0065008;primary metabolic process#GO:0044238;catabolic process#GO:0009056;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;system process#GO:0003008;regulation of blood pressure#GO:0008217;peptide catabolic process#GO:0043171;cellular process#GO:0009987;blood circulation#GO:0008015;multicellular organismal process#GO:0032501;biological regulation#GO:0065007 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 metalloprotease#PC00153;protease#PC00190 HUMAN|HGNC=24250|UniProtKB=Q96D46 Q96D46 NMD3 PTHR12746:SF2 NONSENSE-MEDIATED MRNA DECAY PROTEIN 3 60S RIBOSOMAL EXPORT PROTEIN NMD3 ribosomal large subunit binding#GO:0043023;ribonucleoprotein complex binding#GO:0043021;protein-containing complex binding#GO:0044877;ribosome binding#GO:0043022;binding#GO:0005488 ribosomal subunit export from nucleus#GO:0000054;intracellular transport#GO:0046907;transport#GO:0006810;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;cellular component biogenesis#GO:0044085;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle localization#GO:0051640;ribosome biogenesis#GO:0042254;ribosome localization#GO:0033750;nucleocytoplasmic transport#GO:0006913;localization#GO:0051179;cellular localization#GO:0051641;nuclear transport#GO:0051169;nuclear export#GO:0051168;ribosomal large subunit export from nucleus#GO:0000055;establishment of organelle localization#GO:0051656;ribonucleoprotein complex biogenesis#GO:0022613 nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=32060|UniProtKB=Q5TEC6 Q5TEC6 H3-7 PTHR11426:SF274 HISTONE H3 HISTONE H3-7 cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;mitotic sister chromatid segregation#GO:0000070;chromosome localization#GO:0050000;cellular component assembly#GO:0022607;chromosome segregation#GO:0007059;metaphase chromosome alignment#GO:0051310;mitotic cell cycle process#GO:1903047;chromosome organization#GO:0051276;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;mitotic metaphase chromosome alignment#GO:0007080;protein-containing complex assembly#GO:0065003;cell cycle process#GO:0022402;mitotic nuclear division#GO:0140014;cell cycle#GO:0007049;sister chromatid segregation#GO:0000819;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;nuclear chromosome segregation#GO:0098813;mitotic cell cycle#GO:0000278;kinetochore assembly#GO:0051382;organelle assembly#GO:0070925;nuclear division#GO:0000280;organelle localization#GO:0051640;kinetochore organization#GO:0051383;localization#GO:0051179;organelle fission#GO:0048285 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=18020|UniProtKB=Q16378 Q16378 PRR4 PTHR23203:SF9 PROLINE-RICH PROTEIN PROLINE-RICH PROTEIN 4 antimicrobial response protein#PC00051 HUMAN|HGNC=26522|UniProtKB=Q96MB7 Q96MB7 HARBI1 PTHR22930:SF253 FAMILY NOT NAMED NUCLEASE HARBI1-RELATED HUMAN|HGNC=19578|UniProtKB=Q8N349 Q8N349 OR2L13 PTHR26453:SF102 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2L13 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;response to chemical#GO:0042221;response to stimulus#GO:0050896;detection of chemical stimulus#GO:0009593;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;system process#GO:0003008;nervous system process#GO:0050877;sensory perception#GO:0007600;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=20165|UniProtKB=Q9P2P1 Q9P2P1 NYNRIN PTHR12876:SF2 N4BP1-RELATED PROTEIN NYNRIN RNA binding#GO:0003723;nuclease activity#GO:0004518;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;catalytic activity, acting on RNA#GO:0140098;RNA endonuclease activity#GO:0004521;endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640 regulation of biological quality#GO:0065008;positive regulation of metabolic process#GO:0009893;regulation of mRNA stability#GO:0043488;negative regulation of metabolic process#GO:0009892;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519;regulation of mRNA metabolic process#GO:1903311;mRNA destabilization#GO:0061157;positive regulation of mRNA metabolic process#GO:1903313;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;RNA destabilization#GO:0050779;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of RNA metabolic process#GO:0051252;regulation of RNA stability#GO:0043487;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of mRNA catabolic process#GO:0061014;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of catabolic process#GO:0009896;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;ribonucleoprotein granule#GO:0035770;organelle#GO:0043226;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;nucleus#GO:0005634 endoribonuclease#PC00094 HUMAN|HGNC=33752|UniProtKB=Q6UXN7 Q6UXN7 TOMM20L PTHR12430:SF1 MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM20 TOMM20-LIKE PROTEIN 1 mitochondrial transmembrane transport#GO:1990542;protein transport#GO:0015031;cellular localization#GO:0051641;transmembrane transport#GO:0055085;nucleic acid transport#GO:0050657;localization#GO:0051179;protein localization to mitochondrion#GO:0070585;establishment of RNA localization#GO:0051236;RNA transport#GO:0050658;RNA localization#GO:0006403;protein localization to organelle#GO:0033365;mitochondrial transport#GO:0006839;nucleobase-containing compound transport#GO:0015931;intracellular protein transport#GO:0006886;protein transmembrane transport#GO:0071806;transport#GO:0006810;protein transmembrane import into intracellular organelle#GO:0044743;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;intracellular protein transmembrane transport#GO:0065002;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;nitrogen compound transport#GO:0071705;macromolecule localization#GO:0033036;protein import into mitochondrial matrix#GO:0030150;mitochondrial protein import pathway#GO:7770058 membrane protein complex#GO:0098796;organelle envelope#GO:0031967;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;outer membrane#GO:0019867;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;organelle outer membrane#GO:0031968;cytoplasm#GO:0005737;mitochondrial outer membrane translocase complex#GO:0005742;mitochondrial outer membrane#GO:0005741;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090 transporter#PC00227;primary active transporter#PC00068 HUMAN|HGNC=10322|UniProtKB=Q16540 Q16540 MRPL23 PTHR12059:SF5 RIBOSOMAL PROTEIN L23-RELATED LARGE RIBOSOMAL SUBUNIT PROTEIN UL23M structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mitochondrial translation#GO:0032543;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;biosynthetic process#GO:0009058;metabolic process#GO:0008152;translation#GO:0006412;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;mitochondrial gene expression#GO:0140053 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;mitochondrion#GO:0005739;organelle lumen#GO:0043233;intracellular anatomical structure#GO:0005622;organellar ribosome#GO:0000313;mitochondrial ribosome#GO:0005761;membrane-bounded organelle#GO:0043227;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;large ribosomal subunit#GO:0015934;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;membrane-enclosed lumen#GO:0031974;membraneless organelle#GO:0043228;mitochondrial large ribosomal subunit#GO:0005762 ribosomal protein#PC00202 HUMAN|HGNC=13526|UniProtKB=Q9Y2B5 Q9Y2B5 VPS9D1 PTHR23101:SF98 RAB GDP/GTP EXCHANGE FACTOR VPS9 DOMAIN-CONTAINING PROTEIN 1 binding#GO:0005488;guanyl-nucleotide exchange factor activity#GO:0005085;enzyme binding#GO:0019899;enzyme regulator activity#GO:0030234;small GTPase binding#GO:0031267;protein binding#GO:0005515;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function regulator activity#GO:0098772 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cytosol#GO:0005829;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endocytic vesicle#GO:0030139;intracellular organelle#GO:0043229 protein-binding activity modulator#PC00095;guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=20439|UniProtKB=Q9BZI7 Q9BZI7 UPF3B PTHR13112:SF1 UPF3 REGULATOR OF NONSENSE TRANSCRIPTS-LIKE PROTEIN REGULATOR OF NONSENSE TRANSCRIPTS 3B RNA binding#GO:0003723;mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676 positive regulation of biosynthetic process#GO:0009891;positive regulation of translation#GO:0045727;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;macromolecule metabolic process#GO:0043170;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;regulation of translation#GO:0006417;nucleobase-containing compound catabolic process#GO:0034655;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;nucleic acid catabolic process#GO:0141188;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;RNA catabolic process#GO:0006401;positive regulation of protein metabolic process#GO:0051247;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;RNA metabolic process#GO:0016070;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay#GO:0000184;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of protein metabolic process#GO:0051246;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604 organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 HUMAN|HGNC=1969|UniProtKB=O43916 O43916 CHST1 PTHR10704:SF36 CARBOHYDRATE SULFOTRANSFERASE CARBOHYDRATE SULFOTRANSFERASE 1 transferase activity, transferring sulphur-containing groups#GO:0016782;sulfotransferase activity#GO:0008146;transferase activity#GO:0016740;catalytic activity#GO:0003824 proteoglycan metabolic process#GO:0006029;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;amino sugar metabolic process#GO:0006040;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;sulfur compound metabolic process#GO:0006790;primary metabolic process#GO:0044238 transferase#PC00220;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=24227|UniProtKB=Q9ULG6 Q9ULG6 CCPG1 PTHR28638:SF2 CELL CYCLE PROGRESSION PROTEIN 1 CELL CYCLE PROGRESSION PROTEIN 1 membrane#GO:0016020;cellular anatomical structure#GO:0110165 HUMAN|HGNC=24206|UniProtKB=Q9NUP1 Q9NUP1 BLOC1S4 PTHR16230:SF4 CAPPUCCINO BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 4 response to stimulus#GO:0050896;regulation of body fluid levels#GO:0050878;cellular component organization#GO:0016043;hemostasis#GO:0007599;wound healing#GO:0042060;regulation of biological quality#GO:0065008;cell adhesion#GO:0007155;pigmentation#GO:0043473;cell activation#GO:0001775;biological regulation#GO:0065007;homotypic cell-cell adhesion#GO:0034109;cellular pigmentation#GO:0033059;multicellular organismal process#GO:0032501;coagulation#GO:0050817;cellular process#GO:0009987;organelle organization#GO:0006996;response to stress#GO:0006950;cell-cell adhesion#GO:0098609;response to wounding#GO:0009611;vesicle organization#GO:0016050;blood coagulation#GO:0007596;cellular component organization or biogenesis#GO:0071840;platelet activation#GO:0030168;platelet aggregation#GO:0070527;melanosome organization#GO:0032438 intracellular protein-containing complex#GO:0140535;BLOC-1 complex#GO:0031083;protein-containing complex#GO:0032991 HUMAN|HGNC=26190|UniProtKB=Q8NCE2 Q8NCE2 MTMR14 PTHR13524:SF2 MYOTUBULARIN-RELATED PHOSPHATIDYLINOSITOL-3,5-BISPHOSPHATE 3-PHOSPHATASE MTMR14 phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;phosphatidylinositol-3,5-bisphosphate phosphatase activity#GO:0106018;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 cellular anatomical structure#GO:0110165;perinuclear region of cytoplasm#GO:0048471;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 hydrolase#PC00121;phosphatase#PC00181 HUMAN|HGNC=11265|UniProtKB=P22531 P22531 SPRR2E PTHR48553:SF2 SMALL PROLINE-RICH PROTEIN 2E SMALL PROLINE-RICH PROTEIN 2E HUMAN|HGNC=29576|UniProtKB=Q8TB05 Q8TB05 UBALD1 PTHR31993:SF5 UBA-LIKE DOMAIN-CONTAINING PROTEIN 2 UBA-LIKE DOMAIN-CONTAINING PROTEIN 1 HUMAN|HGNC=24795|UniProtKB=Q6ZS11 Q6ZS11 RINL PTHR23101:SF72 RAB GDP/GTP EXCHANGE FACTOR RAS AND RAB INTERACTOR-LIKE PROTEIN molecular function regulator activity#GO:0098772;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme binding#GO:0019899;binding#GO:0005488;guanyl-nucleotide exchange factor activity#GO:0005085;enzyme regulator activity#GO:0030234;small GTPase binding#GO:0031267;protein binding#GO:0005515 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cytosol#GO:0005829;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;endocytic vesicle#GO:0030139;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 guanyl-nucleotide exchange factor#PC00113;protein-binding activity modulator#PC00095 HUMAN|HGNC=29246|UniProtKB=Q9P2M4 Q9P2M4 TBC1D14 PTHR22957:SF367 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN TBC1 DOMAIN FAMILY MEMBER 14 enzyme activator activity#GO:0008047;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695 regulation of biological process#GO:0050789;regulation of organelle assembly#GO:1902115;regulation of organelle organization#GO:0033043;biological regulation#GO:0065007;regulation of cellular component biogenesis#GO:0044087;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of autophagosome assembly#GO:2000785 endosome#GO:0005768;intracellular organelle#GO:0043229;autophagosome#GO:0005776;recycling endosome#GO:0055037;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;vacuole#GO:0005773;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 GTPase-activating protein#PC00257;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HUMAN|HGNC=20387|UniProtKB=Q9P2X3 Q9P2X3 IMPACT PTHR16301:SF25 IMPACT-RELATED PROTEIN IMPACT regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;post-transcriptional regulation of gene expression#GO:0010608;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of protein metabolic process#GO:0051246;response to stress#GO:0006950;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;cellular response to stress#GO:0033554;regulation of translational initiation#GO:0006446;signaling#GO:0023052;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=5140|UniProtKB=P28356 P28356 HOXD9 PTHR45970:SF4 AGAP004664-PA HOMEOBOX PROTEIN HOX-D9 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;animal gross anatomical part developmental process#GO:0160108;chordate embryonic development#GO:0043009;skeletal system development#GO:0001501;embryo development#GO:0009790;anterior/posterior pattern specification#GO:0009952;multicellular organism development#GO:0007275;embryonic morphogenesis#GO:0048598;animal organ development#GO:0048513;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;animal organ morphogenesis#GO:0009887;pattern specification process#GO:0007389;embryonic organ development#GO:0048568;embryo development ending in birth or egg hatching#GO:0009792;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;skeletal system morphogenesis#GO:0048705;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;regionalization#GO:0003002;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119 HUMAN|HGNC=14851|UniProtKB=Q8NH59 Q8NH59 OR51Q1 PTHR26450:SF84 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 51Q1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=1864|UniProtKB=O00748 O00748 CES2 PTHR11559:SF440 CARBOXYLESTERASE COCAINE ESTERASE hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;carboxylic ester hydrolase activity#GO:0052689;catalytic activity#GO:0003824 esterase#PC00097 HUMAN|HGNC=16439|UniProtKB=Q3SYA9 Q3SYA9 POM121L1P PTHR15566:SF6 POM121-LIKE POM121-LIKE PROTEIN 1-RELATED HUMAN|HGNC=13188|UniProtKB=Q05996 Q05996 ZP2 PTHR23343:SF4 ZONA PELLUCIDA SPERM-BINDING PROTEIN ZONA PELLUCIDA SPERM-BINDING PROTEIN 2 protein binding#GO:0005515;structural molecule activity#GO:0005198;binding#GO:0005488;enzyme binding#GO:0019899;extracellular matrix structural constituent#GO:0005201 binding of sperm to zona pellucida#GO:0007339;cell-cell recognition#GO:0009988;sperm-egg recognition#GO:0035036;cell activation#GO:0001775;cell recognition#GO:0008037;sexual reproduction#GO:0019953;multicellular organismal process#GO:0032501;regulation of reproductive process#GO:2000241;reproductive process#GO:0022414;fertilization#GO:0009566;biological regulation#GO:0065007;single fertilization#GO:0007338;negative regulation of biological process#GO:0048519;cellular process#GO:0009987;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 HUMAN|HGNC=15552|UniProtKB=Q8WWZ1 Q8WWZ1 IL1F10 PTHR10078:SF29 INTERLEUKIN-1 FAMILY MEMBER INTERLEUKIN-1 FAMILY MEMBER 10 molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;cytokine activity#GO:0005125;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545 response to chemical#GO:0042221;response to cytokine#GO:0034097;response to lipid#GO:0033993;cellular response to lipid#GO:0071396;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;cellular response to lipopolysaccharide#GO:0071222;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;cellular process#GO:0009987;response to lipopolysaccharide#GO:0032496;cell surface receptor signaling pathway#GO:0007166;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052;response to molecule of bacterial origin#GO:0002237;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;response to peptide#GO:1901652;cellular response to chemical stimulus#GO:0070887;immune system process#GO:0002376;response to oxygen-containing compound#GO:1901700;biological regulation#GO:0065007;response to other organism#GO:0051707;immune response#GO:0006955;cellular response to molecule of bacterial origin#GO:0071219;response to external stimulus#GO:0009605;defense response#GO:0006952;regulation of cellular process#GO:0050794;response to external biotic stimulus#GO:0043207;cellular response to biotic stimulus#GO:0071216;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;response to bacterium#GO:0009617;cytokine-mediated signaling pathway#GO:0019221;inflammatory response#GO:0006954 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207;cytokine#PC00083;interleukin superfamily#PC00128 HUMAN|HGNC=5114|UniProtKB=P14651 P14651 HOXB3 PTHR45664:SF11 PROTEIN ZERKNUELLT 1-RELATED HOMEOBOX PROTEIN HOX-B3 RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;skeletal system morphogenesis#GO:0048705;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regionalization#GO:0003002;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;developmental process#GO:0032502;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;animal organ morphogenesis#GO:0009887;regulation of macromolecule metabolic process#GO:0060255;embryo development ending in birth or egg hatching#GO:0009792;embryonic organ development#GO:0048568;pattern specification process#GO:0007389;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;embryo development#GO:0009790;anterior/posterior pattern specification#GO:0009952;animal organ development#GO:0048513;multicellular organism development#GO:0007275;embryonic morphogenesis#GO:0048598;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;regulation of transcription by RNA polymerase II#GO:0006357;chordate embryonic development#GO:0043009;animal gross anatomical part developmental process#GO:0160108;skeletal system development#GO:0001501 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 homeodomain transcription factor#PC00119 HUMAN|HGNC=978|UniProtKB=Q9P287 Q9P287 BCCIP PTHR13261:SF0 BRCA2 AND CDKN1A INTERACTING PROTEIN BRCA2 AND CDKN1A-INTERACTING PROTEIN molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;enzyme regulator activity#GO:0030234 regulation of cellular process#GO:0050794;mitotic spindle organization#GO:0007052;mitotic cell cycle#GO:0000278;regulation of macromolecule metabolic process#GO:0060255;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cellular component organization#GO:0016043;cell cycle#GO:0007049;cell cycle process#GO:0022402;regulation of biological process#GO:0050789;microtubule cytoskeleton organization#GO:0000226;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;organelle organization#GO:0006996;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;microtubule anchoring#GO:0034453;cellular component organization or biogenesis#GO:0071840;spindle organization#GO:0007051;microtubule-based process#GO:0007017;mitotic cell cycle process#GO:1903047;regulation of protein modification process#GO:0031399 nucleus#GO:0005634;mitotic spindle pole#GO:0097431;microtubule cytoskeleton#GO:0015630;spindle pole#GO:0000922;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;mitotic spindle#GO:0072686;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;spindle#GO:0005819;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228 HUMAN|HGNC=11819|UniProtKB=Q9Y5J7 Q9Y5J7 TIMM9 PTHR13172:SF2 MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM9B MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM9 molecular carrier activity#GO:0140104;protein carrier activity#GO:0140597 cytoplasm#GO:0005737;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;mitochondrial envelope#GO:0005740;membrane-enclosed lumen#GO:0031974;mitochondrial intermembrane space#GO:0005758;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;organelle envelope#GO:0031967;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 primary active transporter#PC00068;transporter#PC00227 HUMAN|HGNC=22948|UniProtKB=Q9NX02 Q9NX02 NLRP2 PTHR45690:SF14 NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12 NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 2 biological regulation#GO:0065007;regulation of response to external stimulus#GO:0032101;regulation of biological process#GO:0050789;regulation of defense response#GO:0031347;regulation of inflammatory response#GO:0050727;regulation of response to stimulus#GO:0048583;regulation of response to stress#GO:0080134 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090 HUMAN|HGNC=11996|UniProtKB=Q5JU69 Q5JU69 TOR2A PTHR10760:SF4 TORSIN TORSIN-2A endoplasmic reticulum#GO:0005783;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;endoplasmic reticulum lumen#GO:0005788;cytoplasm#GO:0005737;nuclear envelope#GO:0005635;endomembrane system#GO:0012505;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 chaperone#PC00072 Parkinson disease#P00049>Torsin A#P01221 HUMAN|HGNC=25668|UniProtKB=Q7L4P6 Q7L4P6 BEND5 PTHR14628:SF1 BEN DOMAIN-CONTAINING PROTEIN 5 BEN DOMAIN-CONTAINING PROTEIN 5 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519 HUMAN|HGNC=26606|UniProtKB=A6NJ78 A6NJ78 METTL15 PTHR11265:SF1 S-ADENOSYL-METHYLTRANSFERASE MRAW 12S RRNA N(4)-CYTIDINE METHYLTRANSFERASE METTL15-RELATED RNA methyltransferase activity#GO:0008173;rRNA methyltransferase activity#GO:0008649;catalytic activity, acting on RNA#GO:0140098;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a rRNA#GO:0140102;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;N-methyltransferase activity#GO:0008170 rRNA processing#GO:0006364;methylation#GO:0032259;RNA methylation#GO:0001510;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;RNA modification#GO:0009451;macromolecule methylation#GO:0043414;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;rRNA modification#GO:0000154;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;rRNA methylation#GO:0031167;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;rRNA base methylation#GO:0070475;cellular component biogenesis#GO:0044085 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229 metabolite interconversion enzyme#PC00262;methyltransferase#PC00155 HUMAN|HGNC=10466|UniProtKB=Q9BST9 Q9BST9 RTKN PTHR21538:SF19 ANILLIN/RHOTEKIN RTKN RHOTEKIN molecular function regulator activity#GO:0098772;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme inhibitor activity#GO:0004857 cell cycle#GO:0007049;cellular component organization#GO:0016043;cell division#GO:0051301;cell cycle process#GO:0022402;mitotic cell cycle#GO:0000278;mitotic cytokinesis#GO:0000281;actin cytoskeleton organization#GO:0030036;actomyosin structure organization#GO:0031032;cytokinesis#GO:0000910;cortical cytoskeleton organization#GO:0030865;cytokinetic process#GO:0032506;actin filament-based process#GO:0030029;cortical actin cytoskeleton organization#GO:0030866;cytoskeleton-dependent cytokinesis#GO:0061640;septin ring organization#GO:0031106;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;actomyosin contractile ring assembly#GO:0000915;cellular process#GO:0009987;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;septin cytoskeleton organization#GO:0032185;cellular component organization or biogenesis#GO:0071840;mitotic cell cycle process#GO:1903047 cell periphery#GO:0071944;intracellular membraneless organelle#GO:0043232;cell division site#GO:0032153;cytoplasm#GO:0005737;cortical actin cytoskeleton#GO:0030864;actomyosin contractile ring#GO:0005826;cytoskeleton#GO:0005856;contractile ring#GO:0070938;membraneless organelle#GO:0043228;cell cortex#GO:0005938;actin cytoskeleton#GO:0015629;cortical cytoskeleton#GO:0030863;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 non-motor actin binding protein#PC00165 HUMAN|HGNC=28570|UniProtKB=Q9NQM4 Q9NQM4 DNAAF6 PTHR21083:SF1 TWISTER DYNEIN AXONEMAL ASSEMBLY FACTOR 6 protein binding#GO:0005515;binding#GO:0005488 cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cell projection assembly#GO:0030031;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cilium movement involved in cell motility#GO:0060294;protein-containing complex organization#GO:0043933;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;flagellated sperm motility#GO:0030317;plasma membrane bounded cell projection assembly#GO:0120031;reproductive process#GO:0022414;cell projection organization#GO:0030030;microtubule-based movement#GO:0007018;cell motility#GO:0048870;protein-containing complex assembly#GO:0065003;sperm motility#GO:0097722;cilium assembly#GO:0060271;cellular component organization#GO:0016043;axoneme assembly#GO:0035082;cilium organization#GO:0044782;cilium-dependent cell motility#GO:0060285;microtubule cytoskeleton organization#GO:0000226;cilium or flagellum-dependent cell motility#GO:0001539;cilium movement#GO:0003341;axonemal dynein complex assembly#GO:0070286;microtubule bundle formation#GO:0001578;organelle assembly#GO:0070925 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=8526|UniProtKB=Q15070 Q15070 OXA1L PTHR12428:SF66 OXA1 MITOCHONDRIAL INNER MEMBRANE PROTEIN OXA1L molecular carrier activity#GO:0140104;protein carrier activity#GO:0140597;membrane insertase activity#GO:0032977 intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;cellular component organization or biogenesis#GO:0071840;inner mitochondrial membrane organization#GO:0007007;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;mitochondrial membrane organization#GO:0007006;organelle organization#GO:0006996;macromolecule localization#GO:0033036;establishment of protein localization to membrane#GO:0090150;mitochondrion organization#GO:0007005;membrane organization#GO:0061024;protein insertion into membrane#GO:0051205;localization within membrane#GO:0051668;cellular localization#GO:0051641;localization#GO:0051179;protein localization to mitochondrion#GO:0070585;cellular component organization#GO:0016043;protein localization to organelle#GO:0033365 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020 transporter#PC00227 HUMAN|HGNC=18439|UniProtKB=Q8NFR9 Q8NFR9 IL17RE PTHR15583:SF5 INTERLEUKIN-17 RECEPTOR INTERLEUKIN-17 RECEPTOR E signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;immune receptor activity#GO:0140375;transmembrane signaling receptor activity#GO:0004888;cytokine receptor activity#GO:0004896 cytokine-mediated signaling pathway#GO:0019221;response to peptide#GO:1901652;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;cell communication#GO:0007154;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;positive regulation of multicellular organismal process#GO:0051240;cellular response to stimulus#GO:0051716;signaling#GO:0023052;regulation of macromolecule metabolic process#GO:0060255;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;positive regulation of cytokine production#GO:0001819;cell surface receptor signaling pathway#GO:0007166;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of cytokine production#GO:0001817;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of multicellular organismal process#GO:0051239;response to cytokine#GO:0034097;response to chemical#GO:0042221;positive regulation of macromolecule metabolic process#GO:0010604 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=16636|UniProtKB=O60333 O60333 KIF1B PTHR24115:SF328 KINESIN-RELATED KINESIN-LIKE PROTEIN KIF1B cytoskeletal motor activity#GO:0003774;hydrolase activity, acting on acid anhydrides#GO:0016817;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;plus-end-directed microtubule motor activity#GO:0008574;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;ATP-dependent activity#GO:0140657;ribonucleoside triphosphate phosphatase activity#GO:0017111;isomerase activity#GO:0016853;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543;tubulin binding#GO:0015631;hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887;microtubule motor activity#GO:0003777;microtubule binding#GO:0008017;polypeptide conformation or assembly isomerase activity#GO:0120544 transport#GO:0006810;vesicle transport along microtubule#GO:0047496;intracellular transport#GO:0046907;microtubule-based process#GO:0007017;vesicle cytoskeletal trafficking#GO:0099518;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle localization#GO:0051648;axo-dendritic transport#GO:0008088;organelle transport along microtubule#GO:0072384;establishment of vesicle localization#GO:0051650;vesicle-mediated transport#GO:0016192;cytoskeleton-dependent intracellular transport#GO:0030705;retrograde axonal transport#GO:0008090;microtubule-based transport#GO:0099111;organelle localization#GO:0051640;axonal transport#GO:0098930;cellular localization#GO:0051641;localization#GO:0051179;cytosolic transport#GO:0016482;microtubule-based movement#GO:0007018;establishment of organelle localization#GO:0051656 microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;supramolecular fiber#GO:0099512;dendrite#GO:0030425;intracellular organelle#GO:0043229;dendritic tree#GO:0097447;axon#GO:0030424;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;cell projection#GO:0042995;intracellular vesicle#GO:0097708;vesicle#GO:0031982;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;somatodendritic compartment#GO:0036477;microtubule cytoskeleton#GO:0015630;neuron projection#GO:0043005 microtubule or microtubule-binding cytoskeletal protein#PC00157;microtubule binding motor protein#PC00156 HUMAN|HGNC=25425|UniProtKB=Q5VVW2 Q5VVW2 GARNL3 PTHR15711:SF62 RAP GTPASE-ACTIVATING PROTEIN GTPASE-ACTIVATING RAP_RAN-GAP DOMAIN-LIKE PROTEIN 3 enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772 GTPase-activating protein#PC00257;G-protein modulator#PC00022 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Rap1GAP#P00737 HUMAN|HGNC=30917|UniProtKB=O95785 O95785 WIZ PTHR24396:SF22 ZINC FINGER PROTEIN PROTEIN WIZ cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=25326|UniProtKB=Q9H0J4 Q9H0J4 QRICH2 PTHR46766:SF2 GLUTAMINE-RICH PROTEIN 2 GLUTAMINE-RICH PROTEIN 2 microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;flagellated sperm motility#GO:0030317;cellular component assembly#GO:0022607;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;cilium movement involved in cell motility#GO:0060294;cilium-dependent cell motility#GO:0060285;cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;reproductive process#GO:0022414;cell projection organization#GO:0030030;cell motility#GO:0048870;microtubule-based movement#GO:0007018;sperm motility#GO:0097722;cellular component organization#GO:0016043 plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;sperm flagellum#GO:0036126;cellular anatomical structure#GO:0110165;motile cilium#GO:0031514;organelle#GO:0043226;membrane-bounded organelle#GO:0043227;cilium#GO:0005929;9+2 motile cilium#GO:0097729 HUMAN|HGNC=9276|UniProtKB=O75688 O75688 PPM1B PTHR47992:SF105 PROTEIN PHOSPHATASE PROTEIN PHOSPHATASE 1B phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787 regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111;regulation of response to stimulus#GO:0048583;positive regulation of canonical Wnt signaling pathway#GO:0090263;regulation of canonical Wnt signaling pathway#GO:0060828;regulation of canonical NF-kappaB signal transduction#GO:0043122;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of response to stimulus#GO:0048584;positive regulation of Wnt signaling pathway#GO:0030177;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cytosol#GO:0005829;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 protein modifying enzyme#PC00260;protein phosphatase#PC00195 HUMAN|HGNC=7761|UniProtKB=O76050 O76050 NEURL1 PTHR12429:SF13 NEURALIZED E3 UBIQUITIN-PROTEIN LIGASE NEURL1 aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746 establishment of localization#GO:0051234;regulation of neuronal synaptic plasticity#GO:0048168;establishment of protein localization to organelle#GO:0072594;intracellular protein localization#GO:0008104;regulation of synaptic plasticity#GO:0048167;transport#GO:0006810;regulation of response to stimulus#GO:0048583;regulation of cell differentiation#GO:0045595;positive regulation of developmental process#GO:0051094;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;macromolecule localization#GO:0033036;regulation of cell development#GO:0060284;positive regulation of cellular process#GO:0048522;regulation of nervous system development#GO:0051960;localization#GO:0051179;regulation of Notch signaling pathway#GO:0008593;protein localization to organelle#GO:0033365;regulation of cellular process#GO:0050794;positive regulation of neurogenesis#GO:0050769;regulation of cell communication#GO:0010646;regulation of developmental process#GO:0050793;modulation of chemical synaptic transmission#GO:0050804;regulation of neurogenesis#GO:0050767;import into cell#GO:0098657;positive regulation of cell differentiation#GO:0045597;regulation of trans-synaptic signaling#GO:0099177;regulation of multicellular organismal process#GO:0051239;positive regulation of cell development#GO:0010720;positive regulation of biological process#GO:0048518;establishment of protein localization#GO:0045184;regulation of biological quality#GO:0065008;protein transport#GO:0015031;regulation of signaling#GO:0023051;endocytosis#GO:0006897;positive regulation of nervous system development#GO:0051962;positive regulation of multicellular organismal process#GO:0051240;regulation of multicellular organismal development#GO:2000026;regulation of biological process#GO:0050789 postsynaptic density#GO:0014069;cell junction#GO:0030054;cell periphery#GO:0071944;postsynapse#GO:0098794;membrane#GO:0016020;plasma membrane#GO:0005886;postsynaptic specialization#GO:0099572;organelle#GO:0043226;asymmetric synapse#GO:0032279;cellular anatomical structure#GO:0110165;synapse#GO:0045202;neuron to neuron synapse#GO:0098984 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 Notch signaling pathway#P00045>Neuralized#P01117 HUMAN|HGNC=1840|UniProtKB=Q9BXF3 Q9BXF3 CECR2 PTHR47092:SF1 CAT EYE SYNDROME CRITICAL REGION PROTEIN 2 CHROMATIN REMODELING REGULATOR CECR2 sexual reproduction#GO:0019953;single fertilization#GO:0007338;reproductive process#GO:0022414;fertilization#GO:0009566 SWI/SNF superfamily-type complex#GO:0070603;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;ATPase complex#GO:1904949;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ISWI-type complex#GO:0031010;nucleus#GO:0005634;chromatin#GO:0000785;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513 HUMAN|HGNC=4497|UniProtKB=P46093 P46093 GPR4 PTHR24232:SF113 G-PROTEIN COUPLED RECEPTOR G PROTEIN-COUPLED RECEPTOR 4 G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=14945|UniProtKB=B7ZBB8 B7ZBB8 PPP1R3G PTHR12307:SF7 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 3G enzyme binding#GO:0019899;polysaccharide binding#GO:0030247;phosphatase binding#GO:0019902;binding#GO:0005488;protein phosphatase binding#GO:0019903;carbohydrate binding#GO:0030246;protein binding#GO:0005515 regulation of carbohydrate biosynthetic process#GO:0043255;biological regulation#GO:0065007;regulation of polysaccharide metabolic process#GO:0032881;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biosynthetic process#GO:0009889;regulation of polysaccharide biosynthetic process#GO:0032885;regulation of glycogen biosynthetic process#GO:0005979;regulation of carbohydrate metabolic process#GO:0006109 catalytic complex#GO:1902494;protein serine/threonine phosphatase complex#GO:0008287;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 protein-binding activity modulator#PC00095;phosphatase modulator#PC00184 HUMAN|HGNC=30133|UniProtKB=Q8IY49 Q8IY49 MMD2 PTHR20855:SF107 ADIPOR/PROGESTIN RECEPTOR-RELATED MONOCYTE TO MACROPHAGE DIFFERENTIATION FACTOR 2 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=1167|UniProtKB=Q9NQ35 Q9NQ35 NRIP3 PTHR12917:SF16 ASPARTYL PROTEASE DDI-RELATED NUCLEAR RECEPTOR-INTERACTING PROTEIN 3 hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity#GO:0003824;aspartic-type endopeptidase activity#GO:0004190 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;proteolysis#GO:0006508;metabolic process#GO:0008152;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;aspartic protease#PC00053 HUMAN|HGNC=14298|UniProtKB=Q9UBY5 Q9UBY5 LPAR3 PTHR22750:SF21 G-PROTEIN COUPLED RECEPTOR LYSOPHOSPHATIDIC ACID RECEPTOR 3 signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HUMAN|HGNC=7797|UniProtKB=P25963 P25963 NFKBIA PTHR46680:SF1 NF-KAPPA-B INHIBITOR ALPHA NF-KAPPA-B INHIBITOR ALPHA molecular sequestering activity#GO:0140313;transcription factor binding#GO:0008134;binding#GO:0005488;protein sequestering activity#GO:0140311;protein binding#GO:0005515;RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629;DNA-binding transcription factor binding#GO:0140297 regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of signal transduction#GO:0009968;negative regulation of response to stimulus#GO:0048585;regulation of canonical NF-kappaB signal transduction#GO:0043122;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;regulation of cell communication#GO:0010646;negative regulation of canonical NF-kappaB signal transduction#GO:0043124;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 T cell activation#P00053>I kappa B#P01323;B cell activation#P00010>I kappa B#P00392;Apoptosis signaling pathway#P00006>IkappaB#P00292;CCKR signaling map#P06959>IKBalpha#P07053;Toll receptor signaling pathway#P00054>IkappaB#P01338;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>NFkappaB#P00859;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>IkappaB#P00857 HUMAN|HGNC=12236|UniProtKB=A0A1B0GXF2 A0A1B0GXF2 TRBV7-2 PTHR23268:SF108 T-CELL RECEPTOR BETA CHAIN T CELL RECEPTOR BETA VARIABLE 7-2-RELATED cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=9585|UniProtKB=Q13635 Q13635 PTCH1 PTHR46022:SF5 PROTEIN PATCHED PROTEIN PATCHED HOMOLOG 1 transmembrane signaling receptor activity#GO:0004888;G protein-coupled receptor binding#GO:0001664;signaling receptor binding#GO:0005102;binding#GO:0005488;signaling receptor activity#GO:0038023;protein binding#GO:0005515;molecular transducer activity#GO:0060089 negative regulation of cellular process#GO:0048523;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of response to stimulus#GO:0048585;regulation of cellular process#GO:0050794;negative regulation of signal transduction#GO:0009968;regulation of cell communication#GO:0010646;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 Hedgehog signaling pathway#P00025>Patched#P00689 HUMAN|HGNC=10389|UniProtKB=P62244 P62244 RPS15A PTHR11758:SF13 40S RIBOSOMAL PROTEIN S15A SMALL RIBOSOMAL SUBUNIT PROTEIN US8 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 small ribosomal subunit#GO:0015935;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;cytosolic small ribosomal subunit#GO:0022627;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;ribosome#GO:0005840;cytosol#GO:0005829;cytosolic ribosome#GO:0022626;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 ribosomal protein#PC00202;translational protein#PC00263 HUMAN|HGNC=25591|UniProtKB=Q86WR0 Q86WR0 CCDC25 PTHR13049:SF8 DUF814-RELATED COILED-COIL DOMAIN-CONTAINING PROTEIN 25 HUMAN|HGNC=20869|UniProtKB=O95393 O95393 BMP10 PTHR11848:SF39 TGF-BETA FAMILY BONE MORPHOGENETIC PROTEIN 10 signaling receptor regulator activity#GO:0030545;cytokine activity#GO:0005125;receptor ligand activity#GO:0048018;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546 enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cellular response to growth factor stimulus#GO:0071363;regulation of cellular process#GO:0050794;response to growth factor#GO:0070848;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;signaling#GO:0023052;response to endogenous stimulus#GO:0009719;cellular response to stimulus#GO:0051716;BMP signaling pathway#GO:0030509;regulation of biological process#GO:0050789;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;cell surface receptor signaling pathway#GO:0007166;cellular response to BMP stimulus#GO:0071773;response to BMP#GO:0071772;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 growth factor#PC00112 TGF-beta signaling pathway#P00052>TGFbeta#P01286 HUMAN|HGNC=20253|UniProtKB=Q8N6F7 Q8N6F7 GCSAM PTHR35351:SF2 GERMINAL CENTER-ASSOCIATED SIGNALING AND MOTILITY-LIKE PROTEIN GERMINAL CENTER-ASSOCIATED SIGNALING AND MOTILITY PROTEIN regulation of locomotion#GO:0040012;negative regulation of immune system process#GO:0002683;negative regulation of cell motility#GO:2000146;biological regulation#GO:0065007;negative regulation of locomotion#GO:0040013;regulation of signal transduction#GO:0009966;negative regulation of cellular process#GO:0048523;negative regulation of cell migration#GO:0030336;regulation of response to stimulus#GO:0048583;regulation of cell migration#GO:0030334;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of leukocyte migration#GO:0002685;regulation of cell communication#GO:0010646;regulation of B cell receptor signaling pathway#GO:0050855;regulation of lymphocyte migration#GO:2000401;regulation of signaling#GO:0023051;regulation of immune response#GO:0050776;regulation of cell motility#GO:2000145 HUMAN|HGNC=29581|UniProtKB=Q8WW18 Q8WW18 C17orf50 PTHR37878:SF1 HYPOTHETICAL PROTEIN LOC689039 SIMILAR TO HUMAN CHROMOSOME 17 OPEN READING FRAME 50 HUMAN|HGNC=393|UniProtKB=Q9Y243 Q9Y243 AKT3 PTHR24356:SF190 SERINE/THREONINE-PROTEIN KINASE RAC-GAMMA SERINE_THREONINE-PROTEIN KINASE catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674 response to hormone#GO:0009725;cellular response to oxygen-containing compound#GO:1901701;negative regulation of programmed cell death#GO:0043069;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;response to chemical#GO:0042221;cell surface receptor signaling pathway#GO:0007166;regulation of apoptotic process#GO:0042981;response to endogenous stimulus#GO:0009719;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;positive regulation of cell motility#GO:2000147;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;cellular response to hormone stimulus#GO:0032870;signaling#GO:0023052;cellular response to chemical stimulus#GO:0070887;response to oxygen-containing compound#GO:1901700;insulin receptor signaling pathway#GO:0008286;positive regulation of cellular process#GO:0048522;positive regulation of cell migration#GO:0030335;negative regulation of apoptotic process#GO:0043066;cellular response to nitrogen compound#GO:1901699;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;response to peptide hormone#GO:0043434;negative regulation of cellular process#GO:0048523;regulation of cell migration#GO:0030334;cellular response to insulin stimulus#GO:0032869;positive regulation of locomotion#GO:0040017;cellular response to stimulus#GO:0051716;response to insulin#GO:0032868;regulation of cellular process#GO:0050794;cellular response to peptide hormone stimulus#GO:0071375;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cell communication#GO:0007154;regulation of cell motility#GO:2000145;enzyme-linked receptor protein signaling pathway#GO:0007167;response to nitrogen compound#GO:1901698;intracellular signal transduction#GO:0035556 non-receptor serine/threonine protein kinase#PC00167 Huntington disease#P00029>Akt#P00805;p53 pathway#P00059>Akt#P01486;Endothelin signaling pathway#P00019>Akt#P00589;Angiogenesis#P00005>Akt#P00223;FGF signaling pathway#P00021>Akt#P00632;Hypoxia response via HIF activation#P00030>AKT#P00819;p53 pathway feedback loops 2#P04398>AKT#P04665;p53 pathway by glucose deprivation#P04397>Akt#P04641;T cell activation#P00053>Akt#P01332;PI3 kinase pathway#P00048>PKB#P01179;Ras Pathway#P04393>AKT#P04570;Interleukin signaling pathway#P00036>PKB#P00973;EGF receptor signaling pathway#P00018>Akt#P00551;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>AKT#P00827;Apoptosis signaling pathway#P00006>AKT#P00260 HUMAN|HGNC=20760|UniProtKB=Q9BQ24 Q9BQ24 ZFYVE21 PTHR39490:SF8 ARRESTIN DOMAIN-CONTAINING PROTEIN D ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 21 HUMAN|HGNC=1473|UniProtKB=P27824 P27824 CANX PTHR11073:SF11 CALRETICULIN AND CALNEXIN CALNEXIN cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;response to stress#GO:0006950;proteasomal protein catabolic process#GO:0010498;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604;response to chemical#GO:0042221;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;protein folding#GO:0006457;response to stimulus#GO:0050896;catabolic process#GO:0009056;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;response to endoplasmic reticulum stress#GO:0034976;ERAD pathway#GO:0036503;protein metabolic process#GO:0019538 organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 chaperone#PC00072 HUMAN|HGNC=3650|UniProtKB=P39748 P39748 FEN1 PTHR11081:SF58 FLAP ENDONUCLEASE FAMILY MEMBER FLAP ENDONUCLEASE 1 endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;DNA nuclease activity#GO:0004536;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;DNA endonuclease activity, producing 5'-phosphomonoesters#GO:0016888;magnesium ion binding#GO:0000287;cation binding#GO:0043169;hydrolase activity#GO:0016787;transition metal ion binding#GO:0046914;small molecule binding#GO:0036094;ion binding#GO:0043167;catalytic activity, acting on RNA#GO:0140098;RNA endonuclease activity#GO:0004521;catalytic activity, acting on DNA#GO:0140097;5'-3' exonuclease activity#GO:0008409;nuclease activity#GO:0004518;metal ion binding#GO:0046872;DNA endonuclease activity#GO:0004520;binding#GO:0005488;exonuclease activity#GO:0004527 nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;DNA replication#GO:0006260;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;macromolecule metabolic process#GO:0043170;DNA metabolic process#GO:0006259;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 exodeoxyribonuclease#PC00098;DNA metabolism protein#PC00009 HUMAN|HGNC=25899|UniProtKB=Q96T17 Q96T17 MAP7D2 PTHR15073:SF3 MICROTUBULE-ASSOCIATED PROTEIN MAP7 DOMAIN-CONTAINING PROTEIN 2 cellular process#GO:0009987;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of microtubule-based movement#GO:0060632;microtubule bundle formation#GO:0001578;regulation of microtubule-based process#GO:0032886;microtubule-based process#GO:0007017;microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;microtubule cytoskeleton#GO:0015630 non-motor microtubule binding protein#PC00166 HUMAN|HGNC=5923|UniProtKB=A0A0G2JS06 A0A0G2JS06 IGLV5-39 PTHR23267:SF325 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN LAMBDA VARIABLE 5-37-RELATED immune response#GO:0006955;immune system process#GO:0002376;response to stimulus#GO:0050896 protein-containing complex#GO:0032991 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=29368|UniProtKB=Q9C0B2 Q9C0B2 CFAP74 PTHR22538:SF0 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 74 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 74 HUMAN|HGNC=28483|UniProtKB=Q8NDZ6 Q8NDZ6 TMEM161B PTHR13624:SF3 RE42071P TRANSMEMBRANE PROTEIN 161B HUMAN|HGNC=20794|UniProtKB=Q2NKX8 Q2NKX8 ERCC6L PTHR45629:SF13 SNF2/RAD54 FAMILY MEMBER DNA EXCISION REPAIR PROTEIN ERCC-6-LIKE DNA translocase activity#GO:0015616;ATP-dependent activity#GO:0140657;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;ATP-dependent activity, acting on DNA#GO:0008094;catalytic activity, acting on DNA#GO:0140097 macromolecule metabolic process#GO:0043170;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA damage response#GO:0006974;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 damaged DNA-binding protein#PC00086 HUMAN|HGNC=29546|UniProtKB=Q96HL8 Q96HL8 SH3YL1 PTHR15629:SF46 SH3YL1 PROTEIN SH3 DOMAIN-CONTAINING YSC84-LIKE PROTEIN 1 ion binding#GO:0043167;phosphatidylinositol binding#GO:0035091;small molecule binding#GO:0036094;anion binding#GO:0043168;binding#GO:0005488 regulation of biological process#GO:0050789;regulation of plasma membrane bounded cell projection assembly#GO:0120032;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of cellular component biogenesis#GO:0044087;regulation of cell projection organization#GO:0031344;regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of cell projection assembly#GO:0060491 cell projection membrane#GO:0031253;ruffle#GO:0001726;leading edge membrane#GO:0031256;ruffle membrane#GO:0032587;plasma membrane#GO:0005886;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;cell leading edge#GO:0031252;membrane#GO:0016020 cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165;actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=32233|UniProtKB=Q8NAV2 Q8NAV2 C8orf58 PTHR37336:SF1 SIMILAR TO 9930012K11RIK PROTEIN SIMILAR TO HUMAN CHROMOSOME 8 OPEN READING FRAME 58 HUMAN|HGNC=15514|UniProtKB=Q13492 Q13492 PICALM PTHR22951:SF16 CLATHRIN ASSEMBLY PROTEIN PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN ion binding#GO:0043167;phosphatidylinositol-4,5-bisphosphate binding#GO:0005546;binding#GO:0005488;small molecule binding#GO:0036094;anion binding#GO:0043168;phosphatidylinositol bisphosphate binding#GO:1902936;protein binding#GO:0005515;lipid binding#GO:0008289;clathrin binding#GO:0030276;SNARE binding#GO:0000149;phospholipid binding#GO:0005543;phosphatidylinositol phosphate binding#GO:1901981 transport#GO:0006810;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;import into cell#GO:0098657;establishment of localization#GO:0051234;receptor-mediated endocytosis#GO:0006898;vesicle budding from membrane#GO:0006900;vesicle organization#GO:0016050;organelle organization#GO:0006996;cellular component organization#GO:0016043;clathrin-dependent endocytosis#GO:0072583;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;endocytosis#GO:0006897;membrane organization#GO:0061024 vesicle#GO:0031982;synaptic vesicle#GO:0008021;intracellular vesicle#GO:0097708;clathrin-coated pit#GO:0005905;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;synapse#GO:0045202;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;membrane-bounded organelle#GO:0043227;coated vesicle#GO:0030135;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;presynapse#GO:0098793;cell periphery#GO:0071944;secretory vesicle#GO:0099503;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;presynaptic membrane#GO:0042734;transport vesicle#GO:0030133;plasma membrane region#GO:0098590;endomembrane system#GO:0012505;synaptic membrane#GO:0097060;clathrin-coated vesicle#GO:0030136;extrinsic component of membrane#GO:0019898;cell junction#GO:0030054;extrinsic component of plasma membrane#GO:0019897 vesicle coat protein#PC00235 HUMAN|HGNC=12698|UniProtKB=P98155 P98155 VLDLR PTHR24270:SF16 LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED VERY LOW-DENSITY LIPOPROTEIN RECEPTOR protein binding#GO:0005515;binding#GO:0005488 central nervous system development#GO:0007417;endocytosis#GO:0006897;localization#GO:0051179;anatomical structure development#GO:0048856;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;vesicle-mediated transport#GO:0016192;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;cellular process#GO:0009987;multicellular organism development#GO:0007275;establishment of localization#GO:0051234;import into cell#GO:0098657;receptor-mediated endocytosis#GO:0006898;developmental process#GO:0032502;transport#GO:0006810 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 apolipoprotein#PC00052;transfer/carrier protein#PC00219 HUMAN|HGNC=15703|UniProtKB=Q9HBH0 Q9HBH0 RHOF PTHR24072:SF99 RHO FAMILY GTPASE RHO-RELATED GTP-BINDING PROTEIN RHOF guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;protein binding#GO:0005515;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;guanyl nucleotide binding#GO:0019001;nucleoside phosphate binding#GO:1901265;kinase binding#GO:0019900;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;hydrolase activity#GO:0016787;ion binding#GO:0043167;GTPase activity#GO:0003924;small molecule binding#GO:0036094;anion binding#GO:0043168;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824 actin filament-based process#GO:0030029;supramolecular fiber organization#GO:0097435;cell communication#GO:0007154;regulation of organelle organization#GO:0033043;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;signaling#GO:0023052;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;cell motility#GO:0048870;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;regulation of cytoskeleton organization#GO:0051493;regulation of actin filament-based process#GO:0032970;actin filament organization#GO:0007015;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;signal transduction#GO:0007165;organelle organization#GO:0006996;regulation of actin cytoskeleton organization#GO:0032956;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;cell migration#GO:0016477 cell periphery#GO:0071944;cytosol#GO:0005829;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 small GTPase#PC00208;G-protein#PC00020 HUMAN|HGNC=913|UniProtKB=P20160 P20160 AZU1 PTHR24271:SF10 KALLIKREIN-RELATED AZUROCIDIN catalytic activity#GO:0003824;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;serine-type peptidase activity#GO:0008236;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 serine protease#PC00203 HUMAN|HGNC=1910|UniProtKB=Q13111 Q13111 CHAF1A PTHR15272:SF0 CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A CAF-1 SUBUNIT A CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A molecular carrier activity#GO:0140104;protein carrier activity#GO:0140597 protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;protein-DNA complex organization#GO:0071824;nucleosome organization#GO:0034728;protein-containing complex assembly#GO:0065003;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;protein-DNA complex assembly#GO:0065004;chromatin organization#GO:0006325;chromatin remodeling#GO:0006338;cellular component assembly#GO:0022607 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694;nucleus#GO:0005634;chromatin#GO:0000785;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=10770|UniProtKB=Q15393 Q15393 SF3B3 PTHR10644:SF1 DNA REPAIR/RNA PROCESSING CPSF FAMILY SPLICING FACTOR 3B SUBUNIT 3 snRNA binding#GO:0017069;RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380 ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;U2 snRNP#GO:0005686;spliceosomal snRNP complex#GO:0097525;nuclear protein-containing complex#GO:0140513;Sm-like protein family complex#GO:0120114;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;small nuclear ribonucleoprotein complex#GO:0030532;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231 RNA metabolism protein#PC00031;RNA processing factor#PC00147 HUMAN|HGNC=17643|UniProtKB=Q9HD26 Q9HD26 GOPC PTHR16528:SF2 GOLGI-ASSOCIATED PDZ AND COILED-COIL MOTIF-CONTAINING GOLGI-ASSOCIATED PDZ AND COILED-COIL MOTIF-CONTAINING PROTEIN binding#GO:0005488;transmembrane transporter binding#GO:0044325;protein binding#GO:0005515 regulation of protein localization#GO:0032880;biological regulation#GO:0065007;regulation of localization#GO:0032879;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;coated vesicle#GO:0030135;intracellular organelle#GO:0043229;trans-Golgi network transport vesicle#GO:0030140;cytoplasm#GO:0005737;transport vesicle#GO:0030133;endomembrane system#GO:0012505;membrane#GO:0016020;Golgi-associated vesicle#GO:0005798;Golgi apparatus#GO:0005794;clathrin-coated vesicle#GO:0030136 membrane traffic protein#PC00150 HUMAN|HGNC=7223|UniProtKB=P25325 P25325 MPST PTHR11364:SF25 THIOSULFATE SULFERTANSFERASE 3-MERCAPTOPYRUVATE SULFURTRANSFERASE catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring sulphur-containing groups#GO:0016782;sulfurtransferase activity#GO:0016783 metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;tRNA thio-modification#GO:0034227;tRNA wobble uridine modification#GO:0002098;tRNA wobble base modification#GO:0002097;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;tRNA wobble position uridine thiolation#GO:0002143;RNA biosynthetic process#GO:0032774;tRNA modification#GO:0006400 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 transferase#PC00220 HUMAN|HGNC=18138|UniProtKB=Q9Y262 Q9Y262 EIF3L PTHR13242:SF5 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT L translation initiation factor activity#GO:0003743;translation factor activity#GO:0180051 translation#GO:0006412;translational initiation#GO:0006413;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein biosynthetic process#GO:0160307 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;eukaryotic translation initiation factor 3 complex#GO:0005852 translation initiation factor#PC00224 HUMAN|HGNC=12757|UniProtKB=P61964 P61964 WDR5 PTHR22847:SF560 WD40 REPEAT PROTEIN WD REPEAT-CONTAINING PROTEIN 5 chromatin-protein adaptor activity#GO:0140463;histone reader activity#GO:0140566;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulation of gene expression#GO:0010468;positive regulation of gene expression#GO:0010628;transcription by RNA polymerase II#GO:0006366;regulation of nucleobase-containing compound metabolic process#GO:0019219;chromatin organization#GO:0006325;biosynthetic process#GO:0009058;regulation of RNA biosynthetic process#GO:2001141;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;macromolecule biosynthetic process#GO:0009059;positive regulation of cellular process#GO:0048522;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular component organization or biogenesis#GO:0071840;transcription initiation-coupled chromatin remodeling#GO:0045815;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;gene expression#GO:0010467;positive regulation of macromolecule metabolic process#GO:0010604;transcription initiation at RNA polymerase II promoter#GO:0006367;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;RNA metabolic process#GO:0016070;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;nucleic acid biosynthetic process#GO:0141187;DNA-templated transcription initiation#GO:0006352;regulation of transcription by RNA polymerase II#GO:0006357;chromatin remodeling#GO:0006338;cellular component organization#GO:0016043;regulation of biological process#GO:0050789 intracellular organelle lumen#GO:0070013;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;protein acetyltransferase complex#GO:0031248;NSL complex#GO:0044545;membrane-bounded organelle#GO:0043227;acetyltransferase complex#GO:1902493;intracellular anatomical structure#GO:0005622;chromosome#GO:0005694;organelle lumen#GO:0043233;methyltransferase complex#GO:0034708;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;transferase complex#GO:1990234;histone methyltransferase complex#GO:0035097;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;Set1C/COMPASS complex#GO:0048188;histone acetyltransferase complex#GO:0000123;intracellular protein-containing complex#GO:0140535;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;chromatin#GO:0000785;protein-containing complex#GO:0032991;H4 histone acetyltransferase complex#GO:1902562;intracellular membraneless organelle#GO:0043232 HUMAN|HGNC=33984|UniProtKB=A6NK89 A6NK89 RASSF10 PTHR15286:SF13 RAS-ASSOCIATING DOMAIN CONTAINING PROTEIN RAS ASSOCIATION DOMAIN-CONTAINING PROTEIN 10 scaffold/adaptor protein#PC00226 HUMAN|HGNC=18174|UniProtKB=Q9P289 Q9P289 STK26 PTHR48012:SF7 STERILE20-LIKE KINASE, ISOFORM B-RELATED SERINE_THREONINE-PROTEIN KINASE 26 kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;intracellular signal transduction#GO:0035556;regulation of cell motility#GO:2000145;cell communication#GO:0007154;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of locomotion#GO:0040012;negative regulation of locomotion#GO:0040013;negative regulation of cell motility#GO:2000146;biological regulation#GO:0065007;regulation of cell migration#GO:0030334;negative regulation of cellular process#GO:0048523;negative regulation of cell migration#GO:0030336 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=238|UniProtKB=P51828 P51828 ADCY7 PTHR45627:SF9 ADENYLATE CYCLASE TYPE 1 ADENYLATE CYCLASE TYPE 7 lyase activity#GO:0016829;adenylate cyclase activity#GO:0004016;catalytic activity#GO:0003824;phosphorus-oxygen lyase activity#GO:0016849;cyclase activity#GO:0009975 cyclic purine nucleotide metabolic process#GO:0052652;metabolic process#GO:0008152;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing compound biosynthetic process#GO:0034654;nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative biosynthetic process#GO:1901137;signal transduction#GO:0007165;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;ribose phosphate biosynthetic process#GO:0046390;cyclic nucleotide biosynthetic process#GO:0009190;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;G protein-coupled receptor signaling pathway#GO:0007186;ribonucleotide metabolic process#GO:0009259;nucleotide biosynthetic process#GO:0009165;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;regulation of biological process#GO:0050789;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;phosphorus metabolic process#GO:0006793;signaling#GO:0023052;response to stimulus#GO:0050896;small molecule metabolic process#GO:0044281;cyclic nucleotide metabolic process#GO:0009187;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;nucleoside phosphate biosynthetic process#GO:1901293;carbohydrate derivative metabolic process#GO:1901135;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;biosynthetic process#GO:0009058;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;cell communication#GO:0007154;organophosphate biosynthetic process#GO:0090407;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;nucleoside phosphate metabolic process#GO:0006753;regulation of cellular process#GO:0050794 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 adenylate cyclase#PC00043 5HT1 type receptor mediated signaling pathway#P04373>AC#P04406;Beta3 adrenergic receptor signaling pathway#P04379>AC#P04450;Endothelin signaling pathway#P00019>Adenylate cyclase#P00569;GABA-B receptor II signaling#P05731>AC#P05760;Dopamine receptor mediated signaling pathway#P05912>AC#P05947;Opioid prodynorphin pathway#P05916>AC#P06001;Beta1 adrenergic receptor signaling pathway#P04377>AC#P04439;Opioid proenkephalin pathway#P05915>AC#P05993;Beta2 adrenergic receptor signaling pathway#P04378>AC#P04446;5HT4 type receptor mediated signaling pathway#P04376>AC#P04429;Histamine H2 receptor mediated signaling pathway#P04386>AC#P04492;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>cAMP cyclase#P00719;Enkephalin release#P05913>AC#P05978;Opioid proopiomelanocortin pathway#P05917>AC#P06011 HUMAN|HGNC=21931|UniProtKB=Q6ZU65 Q6ZU65 UBN2 PTHR21669:SF10 CAPZ-INTERACTING PROTEIN AND RELATED PROTEINS UBINUCLEIN-2 cellular component organization or biogenesis#GO:0071840;chromatin organization#GO:0006325;cellular component organization#GO:0016043;cellular process#GO:0009987 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 scaffold/adaptor protein#PC00226 HUMAN|HGNC=15757|UniProtKB=Q9P1W8 Q9P1W8 SIRPG PTHR19971:SF6 SIGNAL-REGULATORY PROTEIN BETA SIGNAL-REGULATORY PROTEIN GAMMA regulation of lymphocyte activation#GO:0051249;regulation of cell-cell adhesion#GO:0022407;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of cellular component organization#GO:0051128;positive regulation of multicellular organismal process#GO:0051240;regulation of cell activation#GO:0050865;positive regulation of cell adhesion#GO:0045785;regulation of biological process#GO:0050789;regulation of leukocyte activation#GO:0002694;positive regulation of lymphocyte activation#GO:0051251;positive regulation of cellular component organization#GO:0051130;regulation of multicellular organismal process#GO:0051239;positive regulation of cell activation#GO:0050867;biological regulation#GO:0065007;positive regulation of leukocyte cell-cell adhesion#GO:1903039;regulation of cell adhesion#GO:0030155;regulation of T cell activation#GO:0050863;positive regulation of T cell activation#GO:0050870;positive regulation of endocytosis#GO:0045807;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of transport#GO:0051050;positive regulation of immune system process#GO:0002684;positive regulation of cell-cell adhesion#GO:0022409;regulation of transport#GO:0051049;regulation of localization#GO:0032879;positive regulation of leukocyte activation#GO:0002696;regulation of endocytosis#GO:0030100;regulation of leukocyte cell-cell adhesion#GO:1903037 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=10742|UniProtKB=P04279 P04279 SEMG1 PTHR10547:SF4 SEMENOGELIN/SEMINAL VESICLE SECRETORY PROTEIN SEMENOGELIN-1 spermatogenesis#GO:0007283;developmental process#GO:0032502;cellular developmental process#GO:0048869;cell maturation#GO:0048469;cellular process#GO:0009987;male gamete generation#GO:0048232;developmental maturation#GO:0021700;sperm capacitation#GO:0048240;spermatid differentiation#GO:0048515;spermatid development#GO:0007286;sexual reproduction#GO:0019953;anatomical structure development#GO:0048856;multicellular organismal reproductive process#GO:0048609;developmental process involved in reproduction#GO:0003006;germ cell development#GO:0007281;anatomical structure maturation#GO:0071695;gamete generation#GO:0007276;cell differentiation#GO:0030154;reproductive process#GO:0022414;cell development#GO:0048468;cellular process involved in reproduction in multicellular organism#GO:0022412 vesicle#GO:0031982;intracellular vesicle#GO:0097708;secretory vesicle#GO:0099503;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;extracellular region#GO:0005576;acrosomal vesicle#GO:0001669;membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=8246|UniProtKB=Q13607 Q13607 OR2F1 PTHR26453:SF116 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2F1 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;detection of chemical stimulus#GO:0009593;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;response to stimulus#GO:0050896;response to chemical#GO:0042221;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;nervous system process#GO:0050877;sensory perception#GO:0007600;system process#GO:0003008 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=27954|UniProtKB=Q6ZMR5 Q6ZMR5 TMPRSS11A PTHR24253:SF41 TRANSMEMBRANE PROTEASE SERINE TRANSMEMBRANE PROTEASE SERINE 11A serine hydrolase activity#GO:0017171;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;serine-type peptidase activity#GO:0008236 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;proteolysis#GO:0006508;metabolic process#GO:0008152;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 protease#PC00190;serine protease#PC00203;protein modifying enzyme#PC00260 HUMAN|HGNC=24622|UniProtKB=Q8NFI3 Q8NFI3 ENGASE PTHR13246:SF1 ENDO BETA N-ACETYLGLUCOSAMINIDASE CYTOSOLIC ENDO-BETA-N-ACETYLGLUCOSAMINIDASE hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798 macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;biosynthetic process#GO:0009058;glycoprotein biosynthetic process#GO:0009101;protein N-linked glycosylation#GO:0006487;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 hydrolase#PC00121;deaminase#PC00088 HUMAN|HGNC=17231|UniProtKB=Q9BYQ0 Q9BYQ0 KRTAP9-8 PTHR23262:SF32 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 9-2-RELATED structural protein#PC00211 HUMAN|HGNC=9843|UniProtKB=O60894 O60894 RAMP1 PTHR14076:SF3 RECEPTOR ACTIVITY MODIFYING PROTEIN RAMP RECEPTOR ACTIVITY-MODIFYING PROTEIN 1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;coreceptor activity#GO:0015026 calcium ion transport#GO:0006816;import into cell#GO:0098657;protein localization to cell periphery#GO:1990778;response to chemical#GO:0042221;vesicle-mediated transport#GO:0016192;establishment of protein localization#GO:0045184;signal transduction#GO:0007165;cellular process#GO:0009987;receptor internalization#GO:0031623;response to hormone#GO:0009725;protein transport#GO:0015031;monoatomic ion transport#GO:0006811;cellular localization#GO:0051641;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;endocytosis#GO:0006897;cellular response to hormone stimulus#GO:0032870;regulation of biological process#GO:0050789;protein localization to membrane#GO:0072657;response to endogenous stimulus#GO:0009719;intracellular protein localization#GO:0008104;receptor-mediated endocytosis#GO:0006898;establishment of localization#GO:0051234;transport#GO:0006810;biological regulation#GO:0065007;macromolecule localization#GO:0033036;localization#GO:0051179;monoatomic cation transport#GO:0006812;cell communication#GO:0007154;localization within membrane#GO:0051668;metal ion transport#GO:0030001;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;protein localization to plasma membrane#GO:0072659 cell surface#GO:0009986;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;signaling receptor complex#GO:0043235 transmembrane signal receptor#PC00197 HUMAN|HGNC=25575|UniProtKB=Q9NVF9 Q9NVF9 ETNK2 PTHR22603:SF94 CHOLINE/ETHANOALAMINE KINASE ETHANOLAMINE KINASE 2 phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;organophosphate metabolic process#GO:0019637;phospholipid metabolic process#GO:0006644;biosynthetic process#GO:0009058;phospholipid biosynthetic process#GO:0008654;lipid biosynthetic process#GO:0008610;glycerolipid metabolic process#GO:0046486;glycerophospholipid metabolic process#GO:0006650;lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474;metabolic process#GO:0008152;organophosphate biosynthetic process#GO:0090407 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 kinase#PC00137 HUMAN|HGNC=4680|UniProtKB=O95843 O95843 GUCA1C PTHR23055:SF80 CALCIUM BINDING PROTEINS GUANYLYL CYCLASE-ACTIVATING PROTEIN 3 metal ion binding#GO:0046872;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;cation binding#GO:0043169;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;calcium ion binding#GO:0005509;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047;cyclase regulator activity#GO:0010851 calmodulin-related#PC00061 HUMAN|HGNC=23416|UniProtKB=Q641Q2 Q641Q2 WASHC2A PTHR21669:SF38 CAPZ-INTERACTING PROTEIN AND RELATED PROTEINS WASH COMPLEX SUBUNIT 2A-RELATED phospholipid binding#GO:0005543;binding#GO:0005488;phosphatidylinositol phosphate binding#GO:1901981;lipid binding#GO:0008289;protein-containing complex binding#GO:0044877 localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;endosomal transport#GO:0016197;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;transport#GO:0006810;protein localization to organelle#GO:0033365;vesicle-mediated transport#GO:0016192;cytosolic transport#GO:0016482;macromolecule localization#GO:0033036;retrograde transport, endosome to Golgi#GO:0042147;establishment of localization in cell#GO:0051649;cellular process#GO:0009987 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;vesicle#GO:0031982;intracellular vesicle#GO:0097708;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;intracellular organelle#GO:0043229 scaffold/adaptor protein#PC00226 HUMAN|HGNC=4986|UniProtKB=P05204 P05204 HMGN2 PTHR23087:SF13 NONHISTONE CHROMOSOMAL PROTEIN HMG NON-HISTONE CHROMOSOMAL PROTEIN HMG-17 binding#GO:0005488;chromatin binding#GO:0003682 cellular process#GO:0009987;cellular component organization#GO:0016043;chromatin organization#GO:0006325;cellular component organization or biogenesis#GO:0071840 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=21059|UniProtKB=Q15013 Q15013 MAD2L1BP PTHR15681:SF1 MAD2L1-BINDING PROTEIN MAD2L1-BINDING PROTEIN membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=21360|UniProtKB=Q9HCI6 Q9HCI6 KIAA1586 PTHR46880:SF14 RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN E3 SUMO-PROTEIN LIGASE KIAA1586 catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;SUMO ligase activity#GO:0061665;SUMO transferase activity#GO:0019789 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;protein sumoylation#GO:0016925;metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647;post-translational protein modification#GO:0043687;protein modification process#GO:0036211;primary metabolic process#GO:0044238;protein modification by small protein conjugation#GO:0032446;cellular process#GO:0009987 HUMAN|HGNC=27559|UniProtKB=Q6P474 Q6P474 PDXDC2P PTHR42735:SF1 FAMILY NOT NAMED PYRIDOXAL-DEPENDENT DECARBOXYLASE DOMAIN-CONTAINING PROTEIN 1-RELATED lyase activity#GO:0016829;aldehyde-lyase activity#GO:0016832;catalytic activity#GO:0003824;carbon-carbon lyase activity#GO:0016830 lipid metabolic process#GO:0006629;metabolic process#GO:0008152;sphingolipid metabolic process#GO:0006665;cellular process#GO:0009987;lipid catabolic process#GO:0016042;sphingolipid catabolic process#GO:0030149;primary metabolic process#GO:0044238;catabolic process#GO:0009056 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 HUMAN|HGNC=6644|UniProtKB=P61968 P61968 LMO4 PTHR45787:SF5 LD11652P LIM DOMAIN TRANSCRIPTION FACTOR LMO4 transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;neuron fate commitment#GO:0048663;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;central nervous system neuron differentiation#GO:0021953;central nervous system development#GO:0007417;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;cell fate commitment#GO:0045165;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;nervous system development#GO:0007399;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;multicellular organism development#GO:0007275;neuron differentiation#GO:0030182;cell fate specification#GO:0001708;positive regulation of transcription by RNA polymerase II#GO:0045944 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=21159|UniProtKB=Q8WVD5 Q8WVD5 RNF141 PTHR12109:SF3 RING FINGER PROTEIN 141-RELATED RING FINGER PROTEIN 141 ubiquitin-protein transferase activity#GO:0004842;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746 HUMAN|HGNC=19221|UniProtKB=Q9Y6I7 Q9Y6I7 WSB1 PTHR15622:SF12 WD40 REPEAT PROTEIN WD REPEAT AND SOCS BOX-CONTAINING PROTEIN 1 metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;protein modification process#GO:0036211;primary metabolic process#GO:0044238;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567 HUMAN|HGNC=29372|UniProtKB=Q5JYT7 Q5JYT7 KIAA1755 PTHR45845:SF2 RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR-RELATED KIAA1755 guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=21943|UniProtKB=A6NGB7 A6NGB7 TMEM221 PTHR36132:SF1 TRANSMEMBRANE PROTEIN 221 TRANSMEMBRANE PROTEIN 221 HUMAN|HGNC=12425|UniProtKB=O75386 O75386 TULP3 PTHR16517:SF138 TUBBY-RELATED TUBBY-RELATED PROTEIN 3 macromolecule localization#GO:0033036;localization#GO:0051179;protein localization to organelle#GO:0033365;protein localization to cilium#GO:0061512;intracellular protein localization#GO:0008104 cilium#GO:0005929;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;membrane-bounded organelle#GO:0043227;plasma membrane bounded cell projection#GO:0120025 scaffold/adaptor protein#PC00226 HUMAN|HGNC=20754|UniProtKB=Q9HCX4 Q9HCX4 TRPC7 PTHR10117:SF9 TRANSIENT RECEPTOR POTENTIAL CHANNEL SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 7 channel activity#GO:0015267;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;passive transmembrane transporter activity#GO:0022803;calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;binding#GO:0005488;metal ion transmembrane transporter activity#GO:0046873;alcohol binding#GO:0043178;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215 transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;calcium ion homeostasis#GO:0055074;inorganic ion homeostasis#GO:0098771;sexual reproduction#GO:0019953;reproductive process#GO:0022414;fertilization#GO:0009566;homeostatic process#GO:0042592;metal ion transport#GO:0030001;intracellular monoatomic ion homeostasis#GO:0006873;calcium ion transmembrane transport#GO:0070588;regulation of cytosolic calcium ion concentration#GO:0051480;establishment of localization#GO:0051234;cellular homeostasis#GO:0019725;calcium ion transport#GO:0006816;intracellular calcium ion homeostasis#GO:0006874;intracellular chemical homeostasis#GO:0055082;intracellular monoatomic cation homeostasis#GO:0030003;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;transport#GO:0006810;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;single fertilization#GO:0007338;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987 transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;cation channel complex#GO:0034703;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;cell periphery#GO:0071944;membrane#GO:0016020;membrane protein complex#GO:0098796 ion channel#PC00133 Alzheimer disease-presenilin pathway#P00004>Capacitative calcium channels#P00124 HUMAN|HGNC=11107|UniProtKB=Q92925 Q92925 SMARCD2 PTHR13844:SF2 SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D MEMBER 2 transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 chromatin#GO:0000785;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;chromosome#GO:0005694;SWI/SNF superfamily-type complex#GO:0070603;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;ATPase complex#GO:1904949;catalytic complex#GO:1902494;SWI/SNF complex#GO:0016514;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 chromatin/chromatin-binding, or -regulatory protein#PC00077 Wnt signaling pathway#P00057>SWI/SNF#P01435 HUMAN|HGNC=2734|UniProtKB=Q92499 Q92499 DDX1 PTHR24031:SF307 RNA HELICASE ATP-DEPENDENT RNA HELICASE DDX1 RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;tRNA splicing, via endonucleolytic cleavage and ligation#GO:0006388;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774 intracellular organelle#GO:0043229;cytoplasmic stress granule#GO:0010494;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;cytosol#GO:0005829;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464 RNA helicase#PC00032;RNA metabolism protein#PC00031 HUMAN|HGNC=25061|UniProtKB=Q6PI97 Q6PI97 HOATZ PTHR47231:SF1 UPF0722 PROTEIN C11ORF88 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN HOATZ HUMAN|HGNC=19872|UniProtKB=Q8NFZ6 Q8NFZ6 VN1R2 PTHR24062:SF69 VOMERONASAL TYPE-1 RECEPTOR VOMERONASAL TYPE-1 RECEPTOR 2 transmembrane signal receptor#PC00197 HUMAN|HGNC=13153|UniProtKB=Q15937 Q15937 ZNF79 PTHR24381:SF344 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 79 double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=8974|UniProtKB=Q8NEB9 Q8NEB9 PIK3C3 PTHR10048:SF7 PHOSPHATIDYLINOSITOL KINASE PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3 lipid kinase activity#GO:0001727;phosphotransferase activity, alcohol group as acceptor#GO:0016773;phosphatidylinositol kinase activity#GO:0052742;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824 localization#GO:0051179;cell communication#GO:0007154;organophosphate biosynthetic process#GO:0090407;vacuole organization#GO:0007033;intracellular signal transduction#GO:0035556;organelle assembly#GO:0070925;catabolic process#GO:0009056;phospholipid biosynthetic process#GO:0008654;regulation of cellular process#GO:0050794;phospholipid metabolic process#GO:0006644;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;pexophagy#GO:0000425;establishment of localization#GO:0051234;glycerophospholipid biosynthetic process#GO:0046474;transport#GO:0006810;lipid metabolic process#GO:0006629;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058;biological regulation#GO:0065007;macroautophagy#GO:0016236;organophosphate metabolic process#GO:0019637;glycerolipid biosynthetic process#GO:0045017;process utilizing autophagic mechanism#GO:0061919;phosphatidylinositol phosphate biosynthetic process#GO:0046854;glycerolipid metabolic process#GO:0046486;response to stimulus#GO:0050896;endocytosis#GO:0006897;signaling#GO:0023052;phosphorus metabolic process#GO:0006793;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;import into cell#GO:0098657;autophagosome assembly#GO:0000045;metabolic process#GO:0008152;glycerophospholipid metabolic process#GO:0006650;cellular component assembly#GO:0022607;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;autophagy#GO:0006914;signal transduction#GO:0007165;autophagosome organization#GO:1905037;cellular process#GO:0009987 extrinsic component of membrane#GO:0019898;phagophore assembly site#GO:0000407;transferase complex#GO:1990234;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;membrane#GO:0016020;microbody#GO:0042579;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;transferase complex, transferring phosphorus-containing groups#GO:0061695;endosome#GO:0005768;phosphatidylinositol 3-kinase complex, class III#GO:0035032;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;peroxisome#GO:0005777;membrane protein complex#GO:0098796;vesicle#GO:0031982 kinase#PC00137 p53 pathway#P00059>PI3K#P04609;Endothelin signaling pathway#P00019>PI3K#P00577;Angiogenesis#P00005>PI3K#P00236;PDGF signaling pathway#P00047>PI3K#P01168;Ras Pathway#P04393>PI3K#P04567;Hypoxia response via HIF activation#P00030>PI3K#P00823;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>PI3K#P00900;EGF receptor signaling pathway#P00018>PI3K#P00557;FGF signaling pathway#P00021>PI3K#P00640;p53 pathway feedback loops 2#P04398>PI3K#P04661;T cell activation#P00053>PI3K#P01322;VEGF signaling pathway#P00056>PI3K#P01413;Integrin signalling pathway#P00034>PI3K#P00936 HUMAN|HGNC=6613|UniProtKB=P53667 P53667 LIMK1 PTHR46485:SF7 LIM DOMAIN KINASE 1 LIM DOMAIN KINASE 1 catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674 positive regulation of organelle organization#GO:0010638;positive regulation of cellular component organization#GO:0051130;actin filament-based process#GO:0030029;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;actin cytoskeleton organization#GO:0030036;regulation of cellular component biogenesis#GO:0044087;regulation of stress fiber assembly#GO:0051492;regulation of actin filament bundle assembly#GO:0032231;cellular component organization#GO:0016043;regulation of supramolecular fiber organization#GO:1902903;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;cellular component organization or biogenesis#GO:0071840;positive regulation of actin filament bundle assembly#GO:0032233;regulation of actin filament-based process#GO:0032970;positive regulation of cellular component biogenesis#GO:0044089;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;regulation of actin cytoskeleton organization#GO:0032956;organelle organization#GO:0006996;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of actin filament organization#GO:0110053 nucleus#GO:0005634;neuron projection#GO:0043005;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 Cytoskeletal regulation by Rho GTPase#P00016>LIMK#P00524 HUMAN|HGNC=13073|UniProtKB=P17035 P17035 ZNF28 PTHR24377:SF301 IP01015P-RELATED ZINC FINGER PROTEIN 28 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=9060|UniProtKB=P51178 P51178 PLCD1 PTHR10336:SF210 PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN 1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-1 lipase activity#GO:0016298;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;glycerophospholipase activity#GO:0004620;phospholipase activity#GO:0120569;hydrolase activity, acting on ester bonds#GO:0016788;phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578 cell periphery#GO:0071944;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 hydrolase#PC00121;metabolite interconversion enzyme#PC00262;phospholipase#PC00186;lipase#PC00143 Thyrotropin-releasing hormone receptor signaling pathway#P04394>PLC#P04581;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PLCbetagamma#P00874;5HT2 type receptor mediated signaling pathway#P04374>PLC#P04412;Oxytocin receptor mediated signaling pathway#P04391>PLC beta#P04530;Histamine H1 receptor mediated signaling pathway#P04385>PLC#P04484 HUMAN|HGNC=18985|UniProtKB=Q7Z4W1 Q7Z4W1 DCXR PTHR44252:SF2 D-ERYTHRULOSE REDUCTASE L-XYLULOSE REDUCTASE catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;alcohol dehydrogenase (NADP+) activity#GO:0008106;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614 carbohydrate metabolic process#GO:0005975;small molecule metabolic process#GO:0044281;cellular process#GO:0009987;hexose metabolic process#GO:0019318;primary metabolic process#GO:0044238;glucose metabolic process#GO:0006006;metabolic process#GO:0008152;monosaccharide metabolic process#GO:0005996 oxidoreductase#PC00176;reductase#PC00198 HUMAN|HGNC=9287|UniProtKB=Q9UD71 Q9UD71 PPP1R1B PTHR15417:SF2 PROTEIN PHOSPHATASE INHIBITOR AND DOPAMINE- AND CAMP-REGULATED NEURONAL PHOSPHOPROTEIN PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 1B protein phosphatase regulator activity#GO:0019888;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;phosphatase inhibitor activity#GO:0019212;phosphatase regulator activity#GO:0019208;enzyme inhibitor activity#GO:0004857;protein phosphatase inhibitor activity#GO:0004864 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;biological regulation#GO:0065007;signaling#GO:0023052;cellular response to nitrogen compound#GO:1901699;multicellular organismal process#GO:0032501;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;response to chemical#GO:0042221;cellular response to chemical stimulus#GO:0070887;intracellular signal transduction#GO:0035556;response to nitrogen compound#GO:1901698;cell communication#GO:0007154 cell body#GO:0044297;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;neuronal cell body#GO:0043025;somatodendritic compartment#GO:0036477;cellular anatomical structure#GO:0110165 phosphatase inhibitor#PC00183;protein-binding activity modulator#PC00095;phosphatase modulator#PC00184 Nicotine pharmacodynamics pathway#P06587>PPP1R1B#P06589;Dopamine receptor mediated signaling pathway#P05912>DARPP-32#P05950 HUMAN|HGNC=29328|UniProtKB=Q6P280 Q6P280 ZNF529 PTHR24381:SF309 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 529 double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=29379|UniProtKB=A8K855 A8K855 EFCAB7 PTHR46819:SF1 EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7 EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7 regulation of protein localization to membrane#GO:1905475;regulation of biological process#GO:0050789;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of protein localization#GO:0032880;regulation of localization#GO:0032879 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell projection membrane#GO:0031253;membrane-bounded organelle#GO:0043227;cilium#GO:0005929;plasma membrane region#GO:0098590;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;ciliary membrane#GO:0060170;membrane#GO:0016020;cell periphery#GO:0071944;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090 calmodulin-related#PC00061 HUMAN|HGNC=4057|UniProtKB=P11413 P11413 G6PD PTHR23429:SF23 GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;glucose-6-phosphate dehydrogenase activity#GO:0004345;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614 nucleotide metabolic process#GO:0009117;pyridine-containing compound metabolic process#GO:0072524;NADPH regeneration#GO:0006740;pentose-phosphate shunt#GO:0006098;carbohydrate metabolic process#GO:0005975;nucleoside phosphate metabolic process#GO:0006753;glucose 6-phosphate metabolic process#GO:0051156;small molecule metabolic process#GO:0044281;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;phosphorus metabolic process#GO:0006793;hexose metabolic process#GO:0019318;primary metabolic process#GO:0044238;nucleobase-containing small molecule metabolic process#GO:0055086;glucose metabolic process#GO:0006006;pentose-phosphate shunt, oxidative branch#GO:0009051;generation of precursor metabolites and energy#GO:0006091;metabolic process#GO:0008152;monosaccharide metabolic process#GO:0005996;nucleobase-containing compound metabolic process#GO:0006139;nicotinamide nucleotide metabolic process#GO:0046496;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;NADP+ metabolic process#GO:0006739 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 dehydrogenase#PC00092 HUMAN|HGNC=9748|UniProtKB=P10082 P10082 PYY PTHR10533:SF14 NEUROPEPTIDE Y/PANCREATIC HORMONE/PEPTIDE YY PEPTIDE YY-RELATED molecular function activator activity#GO:0140677;hormone activity#GO:0005179;protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;neuropeptide hormone activity#GO:0005184;G protein-coupled receptor binding#GO:0001664;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;neuropeptide receptor binding#GO:0071855 cell communication#GO:0007154;feeding behavior#GO:0007631;G protein-coupled receptor signaling pathway#GO:0007186;regulation of cellular process#GO:0050794;multicellular organismal process#GO:0032501;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;neuropeptide signaling pathway#GO:0007218;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HUMAN|HGNC=17123|UniProtKB=Q96T83 Q96T83 SLC9A7 PTHR10110:SF62 SODIUM/HYDROGEN EXCHANGER SODIUM_HYDROGEN EXCHANGER 7 secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;antiporter activity#GO:0015297;proton transmembrane transporter activity#GO:0015078;metal ion transmembrane transporter activity#GO:0046873;sodium ion transmembrane transporter activity#GO:0015081;active transmembrane transporter activity#GO:0022804;monoatomic ion transmembrane transporter activity#GO:0015075;metal cation:proton antiporter activity#GO:0051139;monoatomic cation transmembrane transporter activity#GO:0008324;potassium ion transmembrane transporter activity#GO:0015079 sodium ion transport#GO:0006814;intracellular monoatomic ion homeostasis#GO:0006873;inorganic ion import across plasma membrane#GO:0099587;homeostatic process#GO:0042592;metal ion transport#GO:0030001;import across plasma membrane#GO:0098739;regulation of intracellular pH#GO:0051453;regulation of pH#GO:0006885;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;monoatomic ion homeostasis#GO:0050801;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;transport#GO:0006810;chemical homeostasis#GO:0048878;cellular homeostasis#GO:0019725;inorganic cation import across plasma membrane#GO:0098659;intracellular chemical homeostasis#GO:0055082;establishment of localization#GO:0051234;import into cell#GO:0098657 vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;endomembrane system#GO:0012505;recycling endosome#GO:0055037 secondary carrier transporter#PC00258 HUMAN|HGNC=8967|UniProtKB=O95427 O95427 PIGN PTHR12250:SF0 PHOSPHATIDYLINOSITOL GLYCAN, CLASS N GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 1 transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, for other substituted phosphate groups#GO:0016780 phospholipid biosynthetic process#GO:0008654;glycolipid metabolic process#GO:0006664;GPI anchored protein biosynthesis#GO:0180046;liposaccharide metabolic process#GO:1903509;glycerolipid metabolic process#GO:0046486;phospholipid metabolic process#GO:0006644;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;organophosphate biosynthetic process#GO:0090407;glycolipid biosynthetic process#GO:0009247;gene expression#GO:0010467;protein maturation#GO:0051604;lipid biosynthetic process#GO:0008610;glycerophospholipid metabolic process#GO:0006650;GPI anchor biosynthetic process#GO:0006506;biosynthetic process#GO:0009058;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;macromolecule biosynthetic process#GO:0009059;carbohydrate derivative metabolic process#GO:1901135;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;glycerophospholipid biosynthetic process#GO:0046474;GPI anchor metabolic process#GO:0006505 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175 extracellular matrix glycoprotein#PC00100 HUMAN|HGNC=25097|UniProtKB=Q8TDN4 Q8TDN4 CABLES1 PTHR22896:SF1 CDK5 AND ABL1 ENZYME SUBSTRATE 1 CDK5 AND ABL1 ENZYME SUBSTRATE 1 multicellular organism development#GO:0007275;anatomical structure development#GO:0048856;multicellular organismal process#GO:0032501;system development#GO:0048731;nervous system development#GO:0007399;animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=24190|UniProtKB=Q7Z7J9 Q7Z7J9 CAMK2N1 PTHR31007:SF3 CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE II INHIBITOR 2 CALCIUM_CALMODULIN-DEPENDENT PROTEIN KINASE II INHIBITOR 1 enzyme inhibitor activity#GO:0004857;kinase inhibitor activity#GO:0019210;protein kinase regulator activity#GO:0019887;protein kinase inhibitor activity#GO:0004860;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;kinase binding#GO:0019900;binding#GO:0005488;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;enzyme regulator activity#GO:0030234;protein binding#GO:0005515;molecular function inhibitor activity#GO:0140678 kinase inhibitor#PC00139 HUMAN|HGNC=28360|UniProtKB=Q9BW61 Q9BW61 DDA1 PTHR31879:SF6 DET1- AND DDB1-ASSOCIATED PROTEIN 1 DET1- AND DDB1-ASSOCIATED PROTEIN 1 positive regulation of protein metabolic process#GO:0051247;positive regulation of metabolic process#GO:0009893;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434;regulation of protein catabolic process#GO:0042176;positive regulation of protein catabolic process#GO:0045732;positive regulation of proteasomal protein catabolic process#GO:1901800;positive regulation of ubiquitin-dependent protein catabolic process#GO:2000060;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;positive regulation of catabolic process#GO:0009896;regulation of catabolic process#GO:0009894;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of proteasomal protein catabolic process#GO:0061136;positive regulation of macromolecule metabolic process#GO:0010604;biological regulation#GO:0065007;positive regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032436 Cul4-RING E3 ubiquitin ligase complex#GO:0080008;catalytic complex#GO:1902494;transferase complex#GO:1990234;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;intracellular protein-containing complex#GO:0140535;cullin-RING ubiquitin ligase complex#GO:0031461 HUMAN|HGNC=28652|UniProtKB=Q5SXM1 Q5SXM1 ZNF678 PTHR24384:SF127 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED ZINC FINGER PROTEIN 257-RELATED sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218 HUMAN|HGNC=32947|UniProtKB=Q6ZRF8 Q6ZRF8 RNF207 PTHR22635:SF0 RING FINGER PROTEIN 207 RING FINGER PROTEIN 207 heat shock protein binding#GO:0031072;transmembrane transporter binding#GO:0044325;protein-folding chaperone binding#GO:0051087;binding#GO:0005488;Hsp70 protein binding#GO:0030544;protein binding#GO:0005515 regulation of multicellular organismal process#GO:0051239;regulation of heart contraction#GO:0008016;biological regulation#GO:0065007;regulation of developmental process#GO:0050793;regulation of biological process#GO:0050789;regulation of muscle system process#GO:0090257;regulation of anatomical structure morphogenesis#GO:0022603;regulation of system process#GO:0044057;regulation of muscle contraction#GO:0006937 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;perinuclear region of cytoplasm#GO:0048471 HUMAN|HGNC=2298|UniProtKB=P15088 P15088 CPA3 PTHR11705:SF65 PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B MAST CELL CARBOXYPEPTIDASE A exopeptidase activity#GO:0008238;metallocarboxypeptidase activity#GO:0004181;hydrolase activity#GO:0016787;carboxypeptidase activity#GO:0004180;metallopeptidase activity#GO:0008237;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;catalytic activity#GO:0003824;metalloexopeptidase activity#GO:0008235 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;metabolic process#GO:0008152;proteolysis#GO:0006508;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 metalloprotease#PC00153 HUMAN|HGNC=5919|UniProtKB=A0A075B6K6 A0A075B6K6 IGLV4-3 PTHR23267:SF462 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN LAMBDA VARIABLE 4-3 response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 protein-containing complex#GO:0032991 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=28769|UniProtKB=Q6UX65 Q6UX65 DRAM2 PTHR21324:SF10 FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED DNA DAMAGE-REGULATED AUTOPHAGY MODULATOR PROTEIN 2 tissue homeostasis#GO:0001894;regulation of catabolic process#GO:0009894;multicellular organismal-level homeostasis#GO:0048871;retina homeostasis#GO:0001895;biological regulation#GO:0065007;homeostatic process#GO:0042592;regulation of cellular process#GO:0050794;multicellular organismal process#GO:0032501;anatomical structure homeostasis#GO:0060249;regulation of biological process#GO:0050789;regulation of autophagy#GO:0010506;regulation of metabolic process#GO:0019222 lysosome#GO:0005764;vacuole#GO:0005773;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;lytic vacuole#GO:0000323 scaffold/adaptor protein#PC00226 HUMAN|HGNC=30054|UniProtKB=Q8TCE9 Q8TCE9 LGALS14 PTHR11346:SF15 GALECTIN PLACENTAL PROTEIN 13-LIKE carbohydrate binding#GO:0030246;binding#GO:0005488 extracellular matrix protein#PC00102 HUMAN|HGNC=11432|UniProtKB=P56962 P56962 STX17 PTHR19957:SF139 SYNTAXIN SYNTAXIN-17 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;SNAP receptor activity#GO:0005484 localization#GO:0051179;cellular localization#GO:0051641;protein transport#GO:0015031;cellular component organization#GO:0016043;vesicle fusion#GO:0006906;intracellular transport#GO:0046907;transport#GO:0006810;intracellular protein transport#GO:0006886;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;vesicle organization#GO:0016050;organelle organization#GO:0006996;macromolecule localization#GO:0033036;membrane fusion#GO:0061025;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle fusion#GO:0048284;vesicle-mediated transport#GO:0016192;membrane organization#GO:0061024;organelle membrane fusion#GO:0090174 autophagosome membrane#GO:0000421;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;autophagosome#GO:0005776;intracellular membrane-bounded organelle#GO:0043231;SNARE complex#GO:0031201;cellular anatomical structure#GO:0110165;organelle#GO:0043226;membrane protein complex#GO:0098796;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;vacuolar membrane#GO:0005774;cytoplasm#GO:0005737;vacuole#GO:0005773;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;membrane#GO:0016020 SNARE protein#PC00034 HUMAN|HGNC=16014|UniProtKB=Q96PB1 Q96PB1 CASD1 PTHR13533:SF53 N-ACETYLNEURAMINATE 9-O-ACETYLTRANSFERASE N-ACETYLNEURAMINATE (7)9-O-ACETYLTRANSFERASE acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;acyltransferase activity#GO:0016746;acetyltransferase activity#GO:0016407;transferase activity#GO:0016740;catalytic activity#GO:0003824 membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227 acetyltransferase#PC00038;transferase#PC00220 HUMAN|HGNC=44669|UniProtKB=B4E2M5 B4E2M5 ANKRD66 PTHR24201:SF15 ANK_REP_REGION DOMAIN-CONTAINING PROTEIN ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 66 protein-binding activity modulator#PC00095;kinase inhibitor#PC00139 HUMAN|HGNC=32221|UniProtKB=Q96G04 Q96G04 EEF2KMT PTHR14614:SF117 HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN PROTEIN-LYSINE N-METHYLTRANSFERASE EEF2KMT-RELATED catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741;protein methyltransferase activity#GO:0008276;lysine N-methyltransferase activity#GO:0016278;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;protein-lysine N-methyltransferase activity#GO:0016279;N-methyltransferase activity#GO:0008170 protein modifying enzyme#PC00260 HUMAN|HGNC=8857|UniProtKB=Q9Y5Y5 Q9Y5Y5 PEX16 PTHR13299:SF0 PEROXISOMAL MEMBRANE PROTEIN PEX16 PEROXISOMAL MEMBRANE PROTEIN PEX16 peroxisome organization#GO:0007031;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular component organization or biogenesis#GO:0071840 organelle#GO:0043226;cellular anatomical structure#GO:0110165;peroxisomal membrane#GO:0005778;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;peroxisome#GO:0005777;membrane#GO:0016020;microbody#GO:0042579;membrane-bounded organelle#GO:0043227;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;intracellular organelle#GO:0043229 HUMAN|HGNC=14909|UniProtKB=Q9NYW7 Q9NYW7 TAS2R1 PTHR11394:SF149 TASTE RECEPTOR TYPE 2 TASTE RECEPTOR TYPE 2 MEMBER 1 bitter taste receptor activity#GO:0033038;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;taste receptor activity#GO:0008527;transmembrane signaling receptor activity#GO:0004888 detection of chemical stimulus#GO:0009593;sensory perception of bitter taste#GO:0050913;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;response to chemical#GO:0042221;response to stimulus#GO:0050896;multicellular organismal process#GO:0032501;sensory perception#GO:0007600;detection of chemical stimulus involved in sensory perception of taste#GO:0050912;nervous system process#GO:0050877;sensory perception of taste#GO:0050909;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;detection of chemical stimulus involved in sensory perception of bitter taste#GO:0001580 membrane#GO:0016020;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=11338|UniProtKB=O60224 O60224 SSX4 PTHR14112:SF8 SYNOVIAL SARCOMA, X MEMBER PROTEIN SSX4 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 transcription cofactor#PC00217;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=2578|UniProtKB=P04839 P04839 CYBB PTHR11972:SF60 NADPH OXIDASE NADPH OXIDASE 2 oxidoreductase activity, acting on NAD(P)H#GO:0016651;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor#GO:0050664;catalytic activity#GO:0003824 superoxide metabolic process#GO:0006801;response to stimulus#GO:0050896;defense response#GO:0006952;reactive oxygen species metabolic process#GO:0072593;response to stress#GO:0006950;metabolic process#GO:0008152;cellular process#GO:0009987 catalytic complex#GO:1902494;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane#GO:0016020;oxidoreductase complex#GO:1990204;membrane protein complex#GO:0098796;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 oxidase#PC00175;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=30863|UniProtKB=Q9UDW1 Q9UDW1 UQCR10 PTHR12980:SF0 UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX, SUBUNIT X CYTOCHROME B-C1 COMPLEX SUBUNIT 9 metabolic process#GO:0008152;aerobic electron transport chain#GO:0019646;generation of precursor metabolites and energy#GO:0006091;ATP synthesis coupled electron transport#GO:0042773;oxidative phosphorylation#GO:0006119;cellular respiration#GO:0045333;energy derivation by oxidation of organic compounds#GO:0015980;aerobic respiration#GO:0009060;electron transport chain#GO:0022900;mitochondrial electron transport, ubiquinol to cytochrome c#GO:0006122;mitochondrial ATP synthesis coupled electron transport#GO:0042775;respiratory electron transport chain#GO:0022904;cellular process#GO:0009987 membrane protein complex#GO:0098796;membrane#GO:0016020;oxidoreductase complex#GO:1990204;respiratory chain complex#GO:0098803;cytochrome complex#GO:0070069;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;respiratory chain complex III#GO:0045275 oxidoreductase#PC00176;reductase#PC00198 HUMAN|HGNC=571|UniProtKB=P59780 P59780 AP3S2 PTHR11753:SF10 ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY AP-3 COMPLEX SUBUNIT SIGMA-2 establishment of localization#GO:0051234;vesicle-mediated transport#GO:0016192;localization#GO:0051179;transport#GO:0006810;cellular process#GO:0009987 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 membrane traffic protein#PC00150;vesicle coat protein#PC00235 HUMAN|HGNC=15222|UniProtKB=Q8NGK4 Q8NGK4 OR52K1 PTHR26450:SF401 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 52K1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=4029|UniProtKB=Q96DB9 Q96DB9 FXYD5 PTHR14132:SF14 SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT GAMMA FXYD DOMAIN-CONTAINING ION TRANSPORT REGULATOR 5 transporter regulator activity#GO:0141108;ion channel regulator activity#GO:0099106;molecular function regulator activity#GO:0098772;channel regulator activity#GO:0016247 biological regulation#GO:0065007;regulation of monoatomic ion transport#GO:0043269;regulation of metal ion transport#GO:0010959;regulation of cellular process#GO:0050794;positive regulation of biological process#GO:0048518;positive regulation of transport#GO:0051050;regulation of biological process#GO:0050789;positive regulation of cellular process#GO:0048522;regulation of monoatomic ion transmembrane transport#GO:0034765;regulation of transmembrane transport#GO:0034762;regulation of localization#GO:0032879;regulation of transport#GO:0051049;regulation of monoatomic cation transmembrane transport#GO:1904062 primary active transporter#PC00068;transporter#PC00227 HUMAN|HGNC=4027|UniProtKB=Q14802 Q14802 FXYD3 PTHR14132:SF11 SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT GAMMA FXYD DOMAIN-CONTAINING ION TRANSPORT REGULATOR 3 molecular function regulator activity#GO:0098772;channel regulator activity#GO:0016247;ion channel regulator activity#GO:0099106;transporter regulator activity#GO:0141108 regulation of monoatomic cation transmembrane transport#GO:1904062;regulation of localization#GO:0032879;regulation of transport#GO:0051049;regulation of biological process#GO:0050789;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of transport#GO:0051050;regulation of monoatomic ion transmembrane transport#GO:0034765;regulation of transmembrane transport#GO:0034762;biological regulation#GO:0065007;regulation of monoatomic ion transport#GO:0043269;regulation of metal ion transport#GO:0010959;regulation of cellular process#GO:0050794 transporter#PC00227;primary active transporter#PC00068 HUMAN|HGNC=12783|UniProtKB=P56705 P56705 WNT4 PTHR12027:SF101 WNT RELATED PROTEIN WNT-4 molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;frizzled binding#GO:0005109;G protein-coupled receptor binding#GO:0001664;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;molecular function activator activity#GO:0140677;protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488;cytokine activity#GO:0005125 animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;cell communication#GO:0007154;canonical Wnt signaling pathway#GO:0060070;anatomical structure development#GO:0048856;cell fate commitment#GO:0045165;system development#GO:0048731;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;Wnt signaling pathway#GO:0016055;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;signaling#GO:0023052;developmental process#GO:0032502;neuron differentiation#GO:0030182;cell surface receptor signaling pathway#GO:0007166;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;signal transduction#GO:0007165;cellular process#GO:0009987;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;nervous system development#GO:0007399 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 Cadherin signaling pathway#P00012>Wnt#P00474;Alzheimer disease-presenilin pathway#P00004>Wnt#P00142;Wnt signaling pathway#P00057>Wnt#P01444 HUMAN|HGNC=2457|UniProtKB=P68400 P68400 CSNK2A1 PTHR24054:SF16 CASEIN KINASE II SUBUNIT ALPHA CASEIN KINASE II SUBUNIT ALPHA-RELATED protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096 double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;cellular process#GO:0009987;response to stress#GO:0006950;cellular response to stress#GO:0033554;regulation of cell cycle#GO:0051726;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;cytosol#GO:0005829;nucleus#GO:0005634;protein kinase complex#GO:1902911;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234 Cadherin signaling pathway#P00012>Casein kinase II#P00462;Parkinson disease#P00049>Casein kinase II#P01236;Wnt signaling pathway#P00057>Casein Kinase 2#P01459 HUMAN|HGNC=30053|UniProtKB=Q6UQ28 Q6UQ28 PLET1 PTHR22527:SF2 PLACENTA-EXPRESSED TRANSCRIPT 1 PROTEIN PLACENTA-EXPRESSED TRANSCRIPT 1 PROTEIN anatomical structure development#GO:0048856;tissue morphogenesis#GO:0048729;regulation of cell motility#GO:2000145;cell motility#GO:0048870;regulation of cellular process#GO:0050794;positive regulation of locomotion#GO:0040017;negative regulation of cellular process#GO:0048523;regulation of cell migration#GO:0030334;developmental process#GO:0032502;tissue development#GO:0009888;cell migration#GO:0016477;regulation of cell adhesion#GO:0030155;negative regulation of cell adhesion#GO:0007162;epithelium development#GO:0060429;regulation of locomotion#GO:0040012;regulation of cell-substrate adhesion#GO:0010810;biological regulation#GO:0065007;response to wounding#GO:0009611;positive regulation of cell migration#GO:0030335;positive regulation of cellular process#GO:0048522;regulation of cell-matrix adhesion#GO:0001952;wound healing#GO:0042060;animal gross anatomical part developmental process#GO:0160108;response to stimulus#GO:0050896;positive regulation of cell motility#GO:2000147;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;morphogenesis of an epithelium#GO:0002009;response to stress#GO:0006950;cellular process#GO:0009987;positive regulation of biological process#GO:0048518 external side of plasma membrane#GO:0009897;apical part of cell#GO:0045177;side of membrane#GO:0098552;membrane#GO:0016020;apical plasma membrane#GO:0016324;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;plasma membrane region#GO:0098590;plasma membrane#GO:0005886 HUMAN|HGNC=18132|UniProtKB=Q9P2J2 Q9P2J2 IGSF9 PTHR10075:SF139 BASIGIN RELATED PROTEIN TURTLE HOMOLOG A cell adhesion molecule#PC00069 HUMAN|HGNC=19155|UniProtKB=P57773 P57773 GJA9 PTHR11984:SF60 CONNEXIN GAP JUNCTION ALPHA-9 PROTEIN wide pore channel activity#GO:0022829;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 cellular process#GO:0009987;regulation of biological process#GO:0050789;cell communication#GO:0007154;cell-cell signaling#GO:0007267;signaling#GO:0023052;biological regulation#GO:0065007 membrane protein complex#GO:0098796;cell-cell junction#GO:0005911;membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;cell junction#GO:0030054;anchoring junction#GO:0070161 cell junction protein#PC00070;gap junction#PC00105 HUMAN|HGNC=28240|UniProtKB=Q96D96 Q96D96 HVCN1 PTHR46480:SF1 F20B24.22 VOLTAGE-GATED HYDROGEN CHANNEL 1 gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;voltage-gated channel activity#GO:0022832;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;proton transmembrane transporter activity#GO:0015078;passive transmembrane transporter activity#GO:0022803;proton channel activity#GO:0015252;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic cation channel activity#GO:0005261;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;transport#GO:0006810;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;proton transmembrane transport#GO:1902600;monoatomic cation transport#GO:0006812;localization#GO:0051179 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HUMAN|HGNC=5227|UniProtKB=Q9ULV5 Q9ULV5 HSF4 PTHR10015:SF213 HEAT SHOCK TRANSCRIPTION FACTOR HEAT SHOCK FACTOR PROTEIN 4 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;winged helix/forkhead transcription factor#PC00246;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=11240|UniProtKB=Q9NYA1 Q9NYA1 SPHK1 PTHR12358:SF47 SPHINGOSINE KINASE SPHINGOSINE KINASE 1 phosphotransferase activity, alcohol group as acceptor#GO:0016773;lipid kinase activity#GO:0001727;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 metabolic process#GO:0008152;sphingolipid metabolic process#GO:0006665;negative regulation of cellular process#GO:0048523;sphingolipid biosynthetic process#GO:0030148;alcohol metabolic process#GO:0006066;regulation of endocytosis#GO:0030100;regulation of apoptotic process#GO:0042981;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;regulation of transport#GO:0051049;regulation of localization#GO:0032879;alcohol biosynthetic process#GO:0046165;negative regulation of programmed cell death#GO:0043069;cellular process#GO:0009987;negative regulation of apoptotic process#GO:0043066;lipid biosynthetic process#GO:0008610;biological regulation#GO:0065007;biosynthetic process#GO:0009058;cellular response to growth factor stimulus#GO:0071363;sphingoid biosynthetic process#GO:0046520;response to endogenous stimulus#GO:0009719;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;small molecule metabolic process#GO:0044281;regulation of cellular component organization#GO:0051128;response to growth factor#GO:0070848;regulation of cellular process#GO:0050794 metabolite interconversion enzyme#PC00262;kinase#PC00137;transferase#PC00220 VEGF signaling pathway#P00056>SPK#P01404;Angiogenesis#P00005>SPK#P00229 HUMAN|HGNC=28991|UniProtKB=Q92622 Q92622 RUBCN PTHR45971:SF3 PHOX (PX) DOMAIN-CONTAINING PROTEIN RUN DOMAIN BECLIN-1-INTERACTING AND CYSTEINE-RICH DOMAIN-CONTAINING PROTEIN phosphatidylinositol phosphate binding#GO:1901981;lipid binding#GO:0008289;phospholipid binding#GO:0005543;binding#GO:0005488 negative regulation of metabolic process#GO:0009892;negative regulation of transport#GO:0051051;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;regulation of autophagy#GO:0010506;negative regulation of biological process#GO:0048519;negative regulation of cellular component organization#GO:0051129;negative regulation of catabolic process#GO:0009895;negative regulation of protein-containing complex disassembly#GO:0043242;biological regulation#GO:0065007;negative regulation of macroautophagy#GO:0016242;regulation of protein-containing complex disassembly#GO:0043244;regulation of metabolic process#GO:0019222;regulation of macroautophagy#GO:0016241;regulation of localization#GO:0032879;negative regulation of autophagy#GO:0010507;regulation of transport#GO:0051049;regulation of catabolic process#GO:0009894;regulation of endocytosis#GO:0030100;regulation of autophagosome maturation#GO:1901096;negative regulation of cellular process#GO:0048523 intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;late endosome#GO:0005770;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;early endosome#GO:0005769;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=28629|UniProtKB=Q5BKY9 Q5BKY9 FAM133B PTHR31911:SF3 PROTEIN FAM133 PROTEIN FAM133B RNA metabolism protein#PC00031 HUMAN|HGNC=8927|UniProtKB=Q93100 Q93100 PHKB PTHR10749:SF8 PHOSPHORYLASE B KINASE REGULATORY SUBUNIT PHOSPHORYLASE B KINASE REGULATORY SUBUNIT BETA cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;protein kinase complex#GO:1902911;intracellular anatomical structure#GO:0005622;serine/threonine protein kinase complex#GO:1902554;catalytic complex#GO:1902494;transferase complex#GO:1990234;transferase complex, transferring phosphorus-containing groups#GO:0061695 kinase activator#PC00138 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Phosphorylase b kinase#P00716 HUMAN|HGNC=19950|UniProtKB=Q8NG50 Q8NG50 RDM1 PTHR31164:SF1 RAD52 MOTIF-CONTAINING PROTEIN 1 RAD52 MOTIF-CONTAINING PROTEIN 1 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=26043|UniProtKB=A1E959 A1E959 ODAM PTHR16237:SF3 ODONTOGENIC AMELOBLAST-ASSOCIATED PROTEIN ODONTOGENIC AMELOBLAST-ASSOCIATED PROTEIN developmental process#GO:0032502;animal organ development#GO:0048513;response to stress#GO:0006950;response to wounding#GO:0009611;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;odontogenesis of dentin-containing tooth#GO:0042475;biological regulation#GO:0065007;animal gross anatomical part developmental process#GO:0160108;anatomical structure development#GO:0048856;regulation of cell population proliferation#GO:0042127;wound healing#GO:0042060;positive regulation of cell population proliferation#GO:0008284;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;animal organ morphogenesis#GO:0009887;response to stimulus#GO:0050896;odontogenesis#GO:0042476;positive regulation of epithelial cell proliferation#GO:0050679 nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;extracellular region#GO:0005576;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=6086|UniProtKB=P51460 P51460 INSL3 PTHR10423:SF6 INSULIN-LIKE 3 INSULIN-LIKE 3 molecular function activator activity#GO:0140677;hormone activity#GO:0005179;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;biological regulation#GO:0065007;signaling#GO:0023052;regulation of developmental process#GO:0050793;response to stimulus#GO:0050896;regulation of reproductive process#GO:2000241;regulation of cellular process#GO:0050794;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway#GO:0007193;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=24920|UniProtKB=Q96JZ2 Q96JZ2 HSH2D PTHR14388:SF3 T CELL-SPECIFIC ADAPTER PROTEIN TSAD HEMATOPOIETIC SH2 DOMAIN-CONTAINING PROTEIN molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090 HUMAN|HGNC=646|UniProtKB=P10398 P10398 ARAF PTHR44329:SF55 SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED SERINE_THREONINE-PROTEIN KINASE A-RAF catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;MAP kinase kinase kinase activity#GO:0004709 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;MAPK cascade#GO:0000165;biological regulation#GO:0065007;signaling#GO:0023052;intracellular signaling cassette#GO:0141124;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cytosol#GO:0005829;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 VEGF signaling pathway#P00056>Raf#P01417;CCKR signaling map#P06959>A-Raf#P07220;PDGF signaling pathway#P00047>Raf#P01161;FGF signaling pathway#P00021>Raf-1#P00643;Interleukin signaling pathway#P00036>Raf#P00983;Endothelin signaling pathway#P00019>Raf-1#P00587;Integrin signalling pathway#P00034>Raf#P00924;EGF receptor signaling pathway#P00018>Raf-1#P00560;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Raf-1#P00843;T cell activation#P00053>Raf#P01311;B cell activation#P00010>Raf#P00381;Ras Pathway#P04393>Raf#P04556;Angiogenesis#P00005>Raf#P00243 HUMAN|HGNC=8043|UniProtKB=Q02818 Q02818 NUCB1 PTHR19237:SF21 NUCLEOBINDIN NUCLEOBINDIN-1 metal ion binding#GO:0046872;cation binding#GO:0043169;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;calcium ion binding#GO:0005509 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 calmodulin-related#PC00061;calcium-binding protein#PC00060 HUMAN|HGNC=17443|UniProtKB=Q969Z0 Q969Z0 TBRG4 PTHR21228:SF59 FAST LEU-RICH DOMAIN-CONTAINING FAST KINASE DOMAIN-CONTAINING PROTEIN 4 RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of biological quality#GO:0065008;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;regulation of mRNA stability#GO:0043488;regulation of biological process#GO:0050789;regulation of mRNA catabolic process#GO:0061013;regulation of mRNA metabolic process#GO:1903311;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;mitochondrial gene expression#GO:0140053;regulation of RNA metabolic process#GO:0051252;mitochondrial RNA metabolic process#GO:0000959;regulation of RNA stability#GO:0043487;RNA biosynthetic process#GO:0032774;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;post-transcriptional regulation of gene expression#GO:0010608;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;biosynthetic process#GO:0009058;regulation of nucleobase-containing compound metabolic process#GO:0019219;macromolecule biosynthetic process#GO:0009059;mitochondrial RNA processing#GO:0000963;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 organelle lumen#GO:0043233;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane-enclosed lumen#GO:0031974;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228 RNA processing factor#PC00147 HUMAN|HGNC=26509|UniProtKB=Q8N4B1 Q8N4B1 PHETA1 PTHR22902:SF17 SESQUIPEDALIAN SESQUIPEDALIAN-1 localization#GO:0051179;cellular localization#GO:0051641;cytosolic transport#GO:0016482;cellular component organization#GO:0016043;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;establishment of localization#GO:0051234;endosomal transport#GO:0016197;endosome organization#GO:0007032;vesicle organization#GO:0016050;metabolic process#GO:0008152;intracellular transport#GO:0046907;transport#GO:0006810;vesicle-mediated transport#GO:0016192;endomembrane system organization#GO:0010256;organelle organization#GO:0006996;retrograde transport, endosome to Golgi#GO:0042147;establishment of localization in cell#GO:0051649;cellular process#GO:0009987 endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;early endosome#GO:0005769;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;recycling endosome#GO:0055037;Golgi apparatus#GO:0005794;Golgi apparatus subcompartment#GO:0098791;endomembrane system#GO:0012505;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802 membrane traffic protein#PC00150 HUMAN|HGNC=29993|UniProtKB=Q8NHV9 Q8NHV9 RHOXF1 PTHR24329:SF549 HOMEOBOX PROTEIN ARISTALESS RHOX HOMEOBOX FAMILY MEMBER 1 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488 regulation of biological process#GO:0050789;cell development#GO:0048468;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;regulation of RNA metabolic process#GO:0051252;neuron development#GO:0048666;system development#GO:0048731;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;cellular process#GO:0009987;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;nervous system development#GO:0007399;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;neuron differentiation#GO:0030182;developmental process#GO:0032502;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=28894|UniProtKB=Q6K0P9 Q6K0P9 PYHIN1 PTHR12200:SF25 INTERFERON-INDUCIBLE PROTEIN AIM2 FAMILY MEMBER PYRIN AND HIN DOMAIN-CONTAINING PROTEIN 1 DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;binding#GO:0005488;nucleic acid binding#GO:0003676 positive regulation of innate immune response#GO:0045089;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;positive regulation of immune system process#GO:0002684;activation of innate immune response#GO:0002218;biological regulation#GO:0065007;regulation of response to external stimulus#GO:0032101;response to cytokine#GO:0034097;positive regulation of response to stimulus#GO:0048584;response to chemical#GO:0042221;regulation of response to stimulus#GO:0048583;positive regulation of defense response#GO:0031349;positive regulation of immune response#GO:0050778;regulation of response to stress#GO:0080134;positive regulation of response to biotic stimulus#GO:0002833;positive regulation of response to external stimulus#GO:0032103;regulation of innate immune response#GO:0045088;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;regulation of response to biotic stimulus#GO:0002831;regulation of immune system process#GO:0002682;response to stimulus#GO:0050896;regulation of defense response#GO:0031347;regulation of immune response#GO:0050776;immune system process#GO:0002376;response to peptide#GO:1901652 intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654 DNA-binding transcription factor#PC00218 HUMAN|HGNC=20478|UniProtKB=Q8NEX6 Q8NEX6 WFDC11 PTHR19441:SF12 WAP four-disulfide core domain protein PROTEIN WFDC11 enzyme inhibitor activity#GO:0004857;molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866;peptidase regulator activity#GO:0061134;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414;molecular function inhibitor activity#GO:0140678;serine-type endopeptidase inhibitor activity#GO:0004867;enzyme regulator activity#GO:0030234 defense response to other organism#GO:0098542;response to other organism#GO:0051707;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;defense response to symbiont#GO:0140546;immune response#GO:0006955;innate immune response#GO:0045087;antibacterial humoral response#GO:0019731;response to external stimulus#GO:0009605;defense response#GO:0006952;humoral immune response#GO:0006959;antimicrobial humoral response#GO:0019730;response to stimulus#GO:0050896;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;response to bacterium#GO:0009617;immune system process#GO:0002376;defense response to bacterium#GO:0042742 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HUMAN|HGNC=3261|UniProtKB=Q13144 Q13144 EIF2B5 PTHR45887:SF1 TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON TRANSLATION INITIATION FACTOR EIF2B SUBUNIT EPSILON translation factor activity#GO:0180051;molecular function regulator activity#GO:0098772;translation initiation factor activity#GO:0003743;translation initiation factor binding#GO:0031369;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;guanyl-nucleotide exchange factor activity#GO:0005085;binding#GO:0005488;enzyme regulator activity#GO:0030234;protein binding#GO:0005515 guanyl-nucleotide exchange factor complex#GO:0032045;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;cytoplasm#GO:0005737 translation initiation factor#PC00224 HUMAN|HGNC=13825|UniProtKB=Q9BZE9 Q9BZE9 ASPSCR1 PTHR46467:SF1 TETHER CONTAINING UBX DOMAIN FOR GLUT4 TETHER CONTAINING UBX DOMAIN FOR GLUT4 intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;chemical homeostasis#GO:0048878;transport#GO:0006810;establishment of localization#GO:0051234;glucose homeostasis#GO:0042593;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular localization#GO:0051641;localization#GO:0051179;protein transport#GO:0015031;carbohydrate homeostasis#GO:0033500;homeostatic process#GO:0042592 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;vesicle membrane#GO:0012506;nucleus#GO:0005634;vesicle#GO:0031982;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HUMAN|HGNC=16924|UniProtKB=Q8WZ64 Q8WZ64 ARAP2 PTHR45899:SF1 RHO GTPASE ACTIVATING PROTEIN AT 15B, ISOFORM C ARF-GAP WITH RHO-GAP DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 2 ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;binding#GO:0005488;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;lipid binding#GO:0008289;enzyme activator activity#GO:0008047;phospholipid binding#GO:0005543;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;phosphatidylinositol phosphate binding#GO:1901981;molecular function regulator activity#GO:0098772 regulation of actin filament-based process#GO:0032970;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of actin cytoskeleton organization#GO:0032956;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 GTPase-activating protein#PC00257 HUMAN|HGNC=2400|UniProtKB=P26998 P26998 CRYBB3 PTHR11818:SF13 BETA/GAMMA CRYSTALLIN BETA-CRYSTALLIN B3 structural molecule activity#GO:0005198 animal organ development#GO:0048513;multicellular organism development#GO:0007275;system process#GO:0003008;sensory organ development#GO:0007423;developmental process#GO:0032502;lens development in camera-type eye#GO:0002088;multicellular organismal process#GO:0032501;sensory system development#GO:0048880;anatomical structure development#GO:0048856;eye development#GO:0001654;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;camera-type eye development#GO:0043010;nervous system process#GO:0050877;sensory perception#GO:0007600;visual perception#GO:0007601;visual system development#GO:0150063;sensory perception of light stimulus#GO:0050953 structural protein#PC00211 HUMAN|HGNC=1608|UniProtKB=P32248 P32248 CCR7 PTHR10489:SF635 CELL ADHESION MOLECULE C-C CHEMOKINE RECEPTOR TYPE 7 transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488;molecular transducer activity#GO:0060089;protein binding#GO:0005515;cytokine receptor activity#GO:0004896;cytokine binding#GO:0019955;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;immune receptor activity#GO:0140375 regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;signaling#GO:0023052;locomotion#GO:0040011;response to stimulus#GO:0050896;cell motility#GO:0048870;regulation of cellular process#GO:0050794;chemotaxis#GO:0006935;cellular response to chemical stimulus#GO:0070887;immune system process#GO:0002376;positive regulation of cytosolic calcium ion concentration#GO:0007204;cell chemotaxis#GO:0060326;intracellular signal transduction#GO:0035556;regulation of biological quality#GO:0065008;cell communication#GO:0007154;immune response#GO:0006955;signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124;response to chemical#GO:0042221;taxis#GO:0042330;cell migration#GO:0016477;response to external stimulus#GO:0009605;calcium-mediated signaling#GO:0019722 plasma membrane#GO:0005886;cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;membrane#GO:0016020 cell adhesion molecule#PC00069 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CHKR#P00854 HUMAN|HGNC=19177|UniProtKB=Q9NX76 Q9NX76 CMTM6 PTHR22776:SF25 MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN CKLF-LIKE MARVEL TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 6 regulation of biological process#GO:0050789;immune response#GO:0006955;immune system process#GO:0002376;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896 cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;cytoplasm#GO:0005737;plasma membrane#GO:0005886;membrane#GO:0016020;vesicle membrane#GO:0012506;cell periphery#GO:0071944;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;recycling endosome membrane#GO:0055038;recycling endosome#GO:0055037;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;endosome membrane#GO:0010008;intracellular organelle#GO:0043229 scaffold/adaptor protein#PC00226 HUMAN|HGNC=239|UniProtKB=P40145 P40145 ADCY8 PTHR45627:SF1 ADENYLATE CYCLASE TYPE 1 ADENYLATE CYCLASE TYPE 8 catalytic activity#GO:0003824;phosphorus-oxygen lyase activity#GO:0016849;cyclase activity#GO:0009975;lyase activity#GO:0016829;adenylate cyclase activity#GO:0004016 primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;nucleoside phosphate metabolic process#GO:0006753;cell communication#GO:0007154;organophosphate biosynthetic process#GO:0090407;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;carbohydrate derivative metabolic process#GO:1901135;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;cyclic nucleotide metabolic process#GO:0009187;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;nucleoside phosphate biosynthetic process#GO:1901293;phosphorus metabolic process#GO:0006793;regulation of biological process#GO:0050789;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;response to stimulus#GO:0050896;small molecule metabolic process#GO:0044281;signaling#GO:0023052;purine nucleotide biosynthetic process#GO:0006164;G protein-coupled receptor signaling pathway#GO:0007186;purine-containing compound biosynthetic process#GO:0072522;ribonucleotide metabolic process#GO:0009259;cyclic nucleotide biosynthetic process#GO:0009190;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide biosynthetic process#GO:0009165;ribose phosphate biosynthetic process#GO:0046390;signal transduction#GO:0007165;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;cyclic purine nucleotide metabolic process#GO:0052652;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 adenylate cyclase#PC00043 Endothelin signaling pathway#P00019>Adenylate cyclase#P00569;GABA-B receptor II signaling#P05731>AC#P05760;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>cAMP cyclase#P00719 HUMAN|HGNC=24547|UniProtKB=Q6IAN0 Q6IAN0 DHRS7B PTHR44196:SF1 DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7B PEROXISOMAL REDUCTASE ACTIVATING PPAR-GAMMA membrane#GO:0016020;cellular anatomical structure#GO:0110165 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=43561|UniProtKB=H3BMG3 H3BMG3 SMKR1 PTHR37932:SF1 SMALL LYSINE-RICH PROTEIN 1 SMALL LYSINE-RICH PROTEIN 1 HUMAN|HGNC=24201|UniProtKB=Q9NS64 Q9NS64 RPRM PTHR28649:SF6 PROTEIN REPRIMO-RELATED PROTEIN REPRIMO regulation of cellular process#GO:0050794;regulation of cell cycle#GO:0051726;biological regulation#GO:0065007;regulation of mitotic cell cycle#GO:0007346;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=28897|UniProtKB=Q9H7C4 Q9H7C4 SYNC PTHR47147:SF1 SYNCOILIN SYNCOILIN cellular process#GO:0009987;intermediate filament-based process#GO:0045103 membrane#GO:0016020;cytosol#GO:0005829;cell periphery#GO:0071944;Z disc#GO:0030018;contractile muscle fiber#GO:0043292;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;I band#GO:0031674;membraneless organelle#GO:0043228;neuromuscular junction#GO:0031594;sarcolemma#GO:0042383;sarcomere#GO:0030017;cell junction#GO:0030054;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;intracellular organelle#GO:0043229;myofibril#GO:0030016;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512 HUMAN|HGNC=30179|UniProtKB=A6NKF1 A6NKF1 SAC3D1 PTHR12436:SF38 80 KDA MCM3-ASSOCIATED PROTEIN SAC3 DOMAIN-CONTAINING PROTEIN 1 establishment of localization#GO:0051234;spindle organization#GO:0007051;macromolecule metabolic process#GO:0043170;transport#GO:0006810;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;biosynthetic process#GO:0009058;macromolecule biosynthetic process#GO:0009059;nitrogen compound transport#GO:0071705;macromolecule localization#GO:0033036;nuclear export#GO:0051168;nuclear transport#GO:0051169;microtubule cytoskeleton organization#GO:0000226;nucleic acid transport#GO:0050657;localization#GO:0051179;nucleocytoplasmic transport#GO:0006913;organelle assembly#GO:0070925;mRNA transport#GO:0051028;establishment of RNA localization#GO:0051236;RNA localization#GO:0006403;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;cell cycle#GO:0007049;centrosome duplication#GO:0051298;microtubule-based process#GO:0007017;microtubule organizing center organization#GO:0031023;cellular component organization or biogenesis#GO:0071840;chromosome segregation#GO:0007059;metabolic process#GO:0008152;cytoskeleton organization#GO:0007010;gene expression#GO:0010467;cellular component assembly#GO:0022607;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;spindle assembly#GO:0051225;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular localization#GO:0051641;mRNA export from nucleus#GO:0006406;cell cycle process#GO:0022402;centrosome cycle#GO:0007098;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;transcription export complex 2#GO:0070390;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;nucleus#GO:0005634;microtubule cytoskeleton#GO:0015630;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;centrosome#GO:0005813;microtubule organizing center#GO:0005815;spindle#GO:0005819;cytoskeleton#GO:0005856 scaffold/adaptor protein#PC00226 HUMAN|HGNC=30032|UniProtKB=Q6VY07 Q6VY07 PACS1 PTHR13280:SF16 PHOSPHOFURIN ACIDIC CLUSTER SORTING PROTEIN PHOSPHOFURIN ACIDIC CLUSTER SORTING PROTEIN 1 protein localization to organelle#GO:0033365;cellular process#GO:0009987;protein localization to plasma membrane#GO:0072659;protein localization to membrane#GO:0072657;macromolecule localization#GO:0033036;intracellular protein localization#GO:0008104;cellular localization#GO:0051641;localization#GO:0051179;localization within membrane#GO:0051668;protein localization to Golgi apparatus#GO:0034067;protein localization to cell periphery#GO:1990778 HUMAN|HGNC=16400|UniProtKB=Q96P20 Q96P20 NLRP3 PTHR45690:SF25 NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12 NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 3 DNA binding#GO:0003677;protein binding#GO:0005515;DNA-binding transcription factor binding#GO:0140297;sequence-specific DNA binding#GO:0043565;transcription factor binding#GO:0008134;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of response to external stimulus#GO:0032101;negative regulation of response to stimulus#GO:0048585;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of response to stress#GO:0080134;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of non-canonical NF-kappaB signal transduction#GO:1901222;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;regulation of inflammatory response#GO:0050727;regulation of defense response#GO:0031347;regulation of signaling#GO:0023051;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;canonical inflammasome complex#GO:0061702;cytosol#GO:0005829 defense/immunity protein#PC00090 HUMAN|HGNC=30264|UniProtKB=Q8NCN5 Q8NCN5 PDPR PTHR13847:SF193 SARCOSINE DEHYDROGENASE-RELATED PYRUVATE DEHYDROGENASE PHOSPHATASE REGULATORY SUBUNIT, MITOCHONDRIAL cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 dehydrogenase#PC00092 HUMAN|HGNC=4857|UniProtKB=Q00341 Q00341 HDLBP PTHR10627:SF34 SCP160 VIGILIN RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729 RNA metabolism protein#PC00031 HUMAN|HGNC=2550|UniProtKB=O95319 O95319 CELF2 PTHR24012:SF699 RNA BINDING PROTEIN CUGBP ELAV-LIKE FAMILY MEMBER 2 RNA binding#GO:0003723;mRNA 3'-UTR binding#GO:0003730;mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of alternative mRNA splicing, via spliceosome#GO:0000381;RNA metabolic process#GO:0016070;spliceosomal complex assembly#GO:0000245;nucleic acid biosynthetic process#GO:0141187;ribonucleoprotein complex biogenesis#GO:0022613;mRNA metabolic process#GO:0016071;mRNA splicing, via spliceosome#GO:0000398;protein-containing complex assembly#GO:0065003;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;protein-containing complex organization#GO:0043933;protein-RNA complex organization#GO:0071826;regulation of mRNA metabolic process#GO:1903311;cellular component organization or biogenesis#GO:0071840;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;mRNA splice site recognition#GO:0006376;RNA processing#GO:0006396;gene expression#GO:0010467;cellular component assembly#GO:0022607;cellular process#GO:0009987;mRNA processing#GO:0006397;cellular component biogenesis#GO:0044085;regulation of RNA metabolic process#GO:0051252;protein-RNA complex assembly#GO:0022618;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA splicing, via transesterification reactions#GO:0000375;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of mRNA splicing, via spliceosome#GO:0048024;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;nucleobase-containing compound metabolic process#GO:0006139;regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007;biosynthetic process#GO:0009058;regulation of mRNA processing#GO:0050684;regulation of nucleobase-containing compound metabolic process#GO:0019219;macromolecule biosynthetic process#GO:0009059;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 RNA metabolism protein#PC00031 HUMAN|HGNC=29384|UniProtKB=Q3MIS6 Q3MIS6 ZNF528 PTHR24377:SF918 IP01015P-RELATED ZINC FINGER PROTEIN 528-RELATED transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=7785|UniProtKB=O00712 O00712 NFIB PTHR11492:SF4 NUCLEAR FACTOR I NUCLEAR FACTOR 1 B-TYPE sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HUMAN|HGNC=24929|UniProtKB=Q969U7 Q969U7 PSMG2 PTHR12970:SF1 PROTEASOME ASSEMBLY CHAPERONE 2 PROTEASOME ASSEMBLY CHAPERONE 2 cellular component organization or biogenesis#GO:0071840;cellular component assembly#GO:0022607;protein-containing complex organization#GO:0043933;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 chaperone#PC00072 HUMAN|HGNC=14479|UniProtKB=Q7Z2W9 Q7Z2W9 MRPL21 PTHR21349:SF0 50S RIBOSOMAL PROTEIN L21 LARGE RIBOSOMAL SUBUNIT PROTEIN BL21M structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 biosynthetic process#GO:0009058;mitochondrial translation#GO:0032543;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;mitochondrial gene expression#GO:0140053;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;translation#GO:0006412;metabolic process#GO:0008152 mitochondrial large ribosomal subunit#GO:0005762;membraneless organelle#GO:0043228;membrane-enclosed lumen#GO:0031974;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;large ribosomal subunit#GO:0015934;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrial ribosome#GO:0005761;organellar ribosome#GO:0000313;organelle lumen#GO:0043233;mitochondrion#GO:0005739;ribosome#GO:0005840;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 ribosomal protein#PC00202 Methylcitrate cycle#P02754>Aconitase#P03028 HUMAN|HGNC=30594|UniProtKB=Q9H3U1 Q9H3U1 UNC45A PTHR45994:SF3 FI21225P1 PROTEIN UNC-45 HOMOLOG A protein binding#GO:0005515;Hsp90 protein binding#GO:0051879;heat shock protein binding#GO:0031072;binding#GO:0005488 metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;protein folding#GO:0006457;biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=6365|UniProtKB=Q9Y5K2 Q9Y5K2 KLK4 PTHR24271:SF65 KALLIKREIN-RELATED KALLIKREIN-4 serine-type peptidase activity#GO:0008236;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;amelogenesis#GO:0097186;biosynthetic process#GO:0009058;odontogenesis of dentin-containing tooth#GO:0042475;gene expression#GO:0010467;protein maturation#GO:0051604;developmental process#GO:0032502;metabolic process#GO:0008152;anatomical structure formation involved in morphogenesis#GO:0048646;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;animal organ development#GO:0048513;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;odontogenesis#GO:0042476;animal organ morphogenesis#GO:0009887;extracellular structure organization#GO:0043062;animal gross anatomical part developmental process#GO:0160108;external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198;anatomical structure development#GO:0048856;cellular component disassembly#GO:0022411;protein metabolic process#GO:0019538 intracellular organelle#GO:0043229;extracellular region#GO:0005576;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular vesicle#GO:0097708;secretory vesicle#GO:0099503;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 serine protease#PC00203 HUMAN|HGNC=1779|UniProtKB=P49336 P49336 CDK8 PTHR24056:SF243 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE 8 kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;cyclin-dependent protein serine/threonine kinase activity#GO:0004693;protein serine/threonine kinase activity#GO:0004674;cyclin-dependent protein kinase activity#GO:0097472;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 cyclin-dependent protein kinase holoenzyme complex#GO:0000307;protein-containing complex#GO:0032991;nucleus#GO:0005634;mediator complex#GO:0016592;protein kinase complex#GO:1902911;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=13498|UniProtKB=Q9Y2Q1 Q9Y2Q1 ZNF257 PTHR24384:SF127 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED ZINC FINGER PROTEIN 257-RELATED DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218 HUMAN|HGNC=30846|UniProtKB=Q7RTY8 Q7RTY8 TMPRSS7 PTHR24253:SF196 TRANSMEMBRANE PROTEASE SERINE TRANSMEMBRANE PROTEASE SERINE 7 serine-type peptidase activity#GO:0008236;catalytic activity#GO:0003824;peptidase activity#GO:0008233;serine hydrolase activity#GO:0017171;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein processing#GO:0016485;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;protein maturation#GO:0051604;gene expression#GO:0010467;proteolysis#GO:0006508;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 protein modifying enzyme#PC00260;protease#PC00190;serine protease#PC00203 HUMAN|HGNC=56248|UniProtKB=A0A1W2PQ72 A0A1W2PQ72 MSANTD7 PTHR47595:SF4 HEAT SHOCK 70 KDA PROTEIN 14 MYB_SANT-LIKE DNA-BINDING DOMAIN-CONTAINING PROTEIN 7 HUMAN|HGNC=11562|UniProtKB=Q92844 Q92844 TANK PTHR15249:SF0 TRAF FAMILY MEMBER-ASSOCIATED NF-KAPPA-B ACTIVATOR TRAF FAMILY MEMBER-ASSOCIATED NF-KAPPA-B ACTIVATOR Toll receptor signaling pathway#P00054>TANK#P01353 HUMAN|HGNC=23179|UniProtKB=Q86XN6 Q86XN6 ZNF761 PTHR24377:SF825 IP01015P-RELATED ZINC FINGER PROTEIN 761 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=30534|UniProtKB=Q5VTE6 Q5VTE6 ANGEL2 PTHR12121:SF27 CARBON CATABOLITE REPRESSOR PROTEIN 4 RNA 2',3'-CYCLIC PHOSPHATASE ANGEL2 RNA nuclease activity#GO:0004540;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;hydrolase activity#GO:0016787;RNA binding#GO:0003723;nucleic acid binding#GO:0003676;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on RNA#GO:0140098;3'-5' exonuclease activity#GO:0008408;mRNA 3'-UTR binding#GO:0003730;nuclease activity#GO:0004518;binding#GO:0005488;exonuclease activity#GO:0004527;mRNA binding#GO:0003729;3'-5'-RNA exonuclease activity#GO:0000175 negative regulation of macromolecule biosynthetic process#GO:0010558;positive regulation of mRNA metabolic process#GO:1903313;nucleobase-containing compound biosynthetic process#GO:0034654;mRNA 3'-end processing#GO:0031124;metabolic process#GO:0008152;regulation of mRNA stability#GO:0043488;negative regulation of metabolic process#GO:0009892;negative regulation of gene expression#GO:0010629;regulation of mRNA catabolic process#GO:0061013;RNA metabolic process#GO:0016070;positive regulation of metabolic process#GO:0009893;nucleic acid biosynthetic process#GO:0141187;nucleobase-containing compound metabolic process#GO:0006139;mitochondrial RNA processing#GO:0000963;regulation of macromolecule biosynthetic process#GO:0010556;nucleobase-containing compound catabolic process#GO:0034655;regulation of gene expression#GO:0010468;nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay#GO:0000288;catabolic process#GO:0009056;positive regulation of mRNA catabolic process#GO:0061014;nucleic acid metabolic process#GO:0090304;mitochondrial gene expression#GO:0140053;mitochondrial RNA metabolic process#GO:0000959;mitochondrial RNA 3'-end processing#GO:0000965;RNA processing#GO:0006396;gene expression#GO:0010467;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;RNA destabilization#GO:0050779;mRNA catabolic process#GO:0006402;mRNA processing#GO:0006397;regulation of mRNA metabolic process#GO:1903311;RNA 3'-end processing#GO:0031123;macromolecule catabolic process#GO:0009057;mRNA destabilization#GO:0061157;mRNA metabolic process#GO:0016071;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of biological quality#GO:0065008;RNA catabolic process#GO:0006401;biosynthetic process#GO:0009058;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;nucleic acid catabolic process#GO:0141188;macromolecule biosynthetic process#GO:0009059;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of catabolic process#GO:0009894;nuclear-transcribed mRNA catabolic process#GO:0000956;positive regulation of catabolic process#GO:0009896;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;positive regulation of RNA metabolic process#GO:0051254;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;nuclear-transcribed mRNA poly(A) tail shortening#GO:0000289;regulation of macromolecule metabolic process#GO:0060255;primary metabolic process#GO:0044238;regulation of RNA metabolic process#GO:0051252;regulation of RNA stability#GO:0043487 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 mRNA polyadenylation factor#PC00146 HUMAN|HGNC=26050|UniProtKB=Q9BUB7 Q9BUB7 TMEM70 PTHR13281:SF0 TRANSMEMBRANE PROTEIN 70, MITOCHONDRIAL TRANSMEMBRANE PROTEIN 70, MITOCHONDRIAL protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 mitochondrial respiratory chain complex assembly#GO:0033108;mitochondrion organization#GO:0007005;cellular component assembly#GO:0022607;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;mitochondrial proton-transporting ATP synthase complex assembly#GO:0033615 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;organelle envelope#GO:0031967;membrane#GO:0016020;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=5551|UniProtKB=A0A0C4DH33 A0A0C4DH33 IGHV1-24 PTHR23266:SF275 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 1-24 antigen binding#GO:0003823;binding#GO:0005488 immune response#GO:0006955;response to stimulus#GO:0050896;adaptive immune response#GO:0002250;immune system process#GO:0002376;immune effector process#GO:0002252;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=19183|UniProtKB=Q9P1Z3 Q9P1Z3 HCN3 PTHR45689:SF7 I[[H]] CHANNEL, ISOFORM E POTASSIUM_SODIUM HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNEL 3 potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843 sodium ion transport#GO:0006814;regulation of biological process#GO:0050789;metal ion transport#GO:0030001;regulation of cellular process#GO:0050794;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813;transport#GO:0006810;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234 monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005;transporter complex#GO:1990351;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;transmembrane transporter complex#GO:1902495;dendrite#GO:0030425;axon#GO:0030424;dendritic tree#GO:0097447 ion channel#PC00133;transporter#PC00227 HUMAN|HGNC=619|UniProtKB=Q9BQE5 Q9BQE5 APOL2 PTHR14096:SF27 APOLIPOPROTEIN L APOLIPOPROTEIN L2 lipid binding#GO:0008289;binding#GO:0005488 cellular anatomical structure#GO:0110165;membrane#GO:0016020 transfer/carrier protein#PC00219;apolipoprotein#PC00052 HUMAN|HGNC=53894|UniProtKB=A0A1W2PQ73 A0A1W2PQ73 ERFL PTHR11849:SF165 ETS ETS DOMAIN-CONTAINING TRANSCRIPTION FACTOR ERF-LIKE DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;developmental process#GO:0032502;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA-binding transcription factor#PC00218;winged helix/forkhead transcription factor#PC00246 HUMAN|HGNC=5918|UniProtKB=A0A075B6K5 A0A075B6K5 IGLV3-9 PTHR23267:SF511 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN LAMBDA VARIABLE 3-9 immune system process#GO:0002376;immune response#GO:0006955;response to stimulus#GO:0050896 protein-containing complex#GO:0032991 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=9311|UniProtKB=Q13362 Q13362 PPP2R5C PTHR10257:SF123 SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;protein phosphatase regulator activity#GO:0019888;phosphatase activator activity#GO:0019211;phosphatase regulator activity#GO:0019208;enzyme regulator activity#GO:0030234;enzyme activator activity#GO:0008047 cellular process#GO:0009987;cell cycle process#GO:0022402;cellular component organization#GO:0016043;cell cycle#GO:0007049;organelle organization#GO:0006996;chromosome organization#GO:0051276;meiotic sister chromatid cohesion#GO:0051177;sister chromatid cohesion#GO:0007062;cellular component organization or biogenesis#GO:0071840 cytosol#GO:0005829;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;protein serine/threonine phosphatase complex#GO:0008287;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;protein phosphatase#PC00195 Wnt signaling pathway#P00057>PP2A#P01438;FGF signaling pathway#P00021>PP2A#P00629;EGF receptor signaling pathway#P00018>PP2A#P00547 HUMAN|HGNC=16387|UniProtKB=Q9BZF2 Q9BZF2 OSBPL7 PTHR10972:SF85 OXYSTEROL-BINDING PROTEIN-RELATED OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 7 alcohol binding#GO:0043178;cholesterol binding#GO:0015485;lipid binding#GO:0008289;steroid binding#GO:0005496;binding#GO:0005488;small molecule binding#GO:0036094;sterol binding#GO:0032934 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;perinuclear region of cytoplasm#GO:0048471;nuclear envelope#GO:0005635;plasma membrane#GO:0005886;cytoplasm#GO:0005737;cytosol#GO:0005829;membrane#GO:0016020;nucleus#GO:0005634;cell periphery#GO:0071944;nuclear membrane#GO:0031965;organelle membrane#GO:0031090;endoplasmic reticulum#GO:0005783 transfer/carrier protein#PC00219 HUMAN|HGNC=21916|UniProtKB=Q4G0A6 Q4G0A6 MINDY4 PTHR12473:SF8 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MINDY-4-RELATED UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MINDY-4-RELATED HUMAN|HGNC=13598|UniProtKB=Q9UKC9 Q9UKC9 FBXL2 PTHR13382:SF40 MITOCHONDRIAL ATP SYNTHASE COUPLING FACTOR B F-BOX_LRR-REPEAT PROTEIN 2 ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cullin-RING ubiquitin ligase complex#GO:0031461;cytoplasm#GO:0005737;SCF ubiquitin ligase complex#GO:0019005;ubiquitin ligase complex#GO:0000151;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;transferase complex#GO:1990234 ATP synthase#PC00002 HUMAN|HGNC=10020|UniProtKB=O43353 O43353 RIPK2 PTHR44329:SF9 SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED RECEPTOR-INTERACTING SERINE_THREONINE-PROTEIN KINASE 2 protein serine/threonine kinase activity#GO:0004674;MAP kinase kinase kinase activity#GO:0004709;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096 cell communication#GO:0007154;response to external biotic stimulus#GO:0043207;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;response to external stimulus#GO:0009605;defense response#GO:0006952;innate immune response#GO:0045087;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;response to other organism#GO:0051707;positive regulation of response to stimulus#GO:0048584;immune response#GO:0006955;positive regulation of cellular process#GO:0048522;regulation of canonical NF-kappaB signal transduction#GO:0043122;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;immune system process#GO:0002376;regulation of intracellular signal transduction#GO:1902531;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;positive regulation of canonical NF-kappaB signal transduction#GO:0043123;defense response to other organism#GO:0098542;signal transduction#GO:0007165;defense response to symbiont#GO:0140546;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;response to biotic stimulus#GO:0009607;response to stress#GO:0006950 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=42400|UniProtKB=Q68D85 Q68D85 NCR3LG1 PTHR23411:SF49 TAPASIN NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 3 LIGAND 1 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=4915|UniProtKB=Q9H422 Q9H422 HIPK3 PTHR24058:SF53 DUAL SPECIFICITY PROTEIN KINASE HOMEODOMAIN-INTERACTING PROTEIN KINASE 3 transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;transcription corepressor activity#GO:0003714;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;transcription coregulator activity#GO:0003712;catalytic activity, acting on a protein#GO:0140096;transcription coactivator activity#GO:0003713;transcription regulator activity#GO:0140110;binding#GO:0005488;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein binding#GO:0005515 regulation of biological process#GO:0050789;apoptotic process#GO:0006915;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;intrinsic apoptotic signaling pathway by p53 class mediator#GO:0072332;cellular response to stress#GO:0033554;signal transduction by p53 class mediator#GO:0072331;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;intrinsic apoptotic signaling pathway#GO:0097193;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;intrinsic apoptotic signaling pathway in response to DNA damage#GO:0008630;response to stress#GO:0006950;positive regulation of macromolecule metabolic process#GO:0010604;cell surface receptor signaling pathway#GO:0007166;positive regulation of transcription by RNA polymerase II#GO:0045944;cell death#GO:0008219;cellular response to stimulus#GO:0051716;programmed cell death#GO:0012501;intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator#GO:0042771;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;smoothened signaling pathway#GO:0007224;intracellular signal transduction#GO:0035556;regulation of RNA metabolic process#GO:0051252;cell communication#GO:0007154;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;DNA damage response#GO:0006974;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;apoptotic signaling pathway#GO:0097190 membraneless organelle#GO:0043228;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;cytoplasm#GO:0005737;nuclear body#GO:0016604;intracellular membraneless organelle#GO:0043232;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;PML body#GO:0016605 protein modifying enzyme#PC00260 HUMAN|HGNC=2456|UniProtKB=Q9Y6M4 Q9Y6M4 CSNK1G3 PTHR11909:SF151 CASEIN KINASE-RELATED CASEIN KINASE I ISOFORM GAMMA-3 catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 positive regulation of signaling#GO:0023056;cell communication#GO:0007154;regulation of signaling#GO:0023051;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111;signaling#GO:0023052;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;positive regulation of canonical Wnt signaling pathway#GO:0090263;regulation of response to stimulus#GO:0048583;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of response to stimulus#GO:0048584;positive regulation of Wnt signaling pathway#GO:0030177;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of canonical Wnt signaling pathway#GO:0060828 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cell periphery#GO:0071944;nucleus#GO:0005634;membrane#GO:0016020 non-receptor serine/threonine protein kinase#PC00167 Wnt signaling pathway#P00057>Casein Kinase 1#P01460;Parkinson disease#P00049>Casein kinase I#P01242 HUMAN|HGNC=12153|UniProtKB=A0A075B6T8 A0A075B6T8 TRAV9-1 PTHR19367:SF36 T-CELL RECEPTOR ALPHA CHAIN V REGION T CELL RECEPTOR ALPHA VARIABLE 9-1 adaptive immune response#GO:0002250;response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 protein-containing complex#GO:0032991 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=16776|UniProtKB=Q9BQ66 Q9BQ66 KRTAP4-12 PTHR23262:SF219 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 4-12 structural protein#PC00211 HUMAN|HGNC=10998|UniProtKB=Q6P1M0 Q6P1M0 SLC27A4 PTHR43107:SF11 LONG-CHAIN FATTY ACID TRANSPORT PROTEIN LONG-CHAIN FATTY ACID TRANSPORT PROTEIN 4 carboxylic acid transmembrane transporter activity#GO:0046943;ATP-dependent activity#GO:0140657;ligase activity, forming carbon-sulfur bonds#GO:0016877;transporter activity#GO:0005215;ligase activity#GO:0016874;transmembrane transporter activity#GO:0022857;catalytic activity#GO:0003824;monocarboxylic acid transmembrane transporter activity#GO:0008028 macromolecule localization#GO:0033036;long-chain fatty acid metabolic process#GO:0001676;cellular process#GO:0009987;lipid transport#GO:0006869;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;lipid metabolic process#GO:0006629;organic acid transport#GO:0015849;transport#GO:0006810;carboxylic acid transport#GO:0046942;establishment of localization#GO:0051234;import into cell#GO:0098657;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;small molecule metabolic process#GO:0044281;lipid localization#GO:0010876;oxoacid metabolic process#GO:0043436;localization#GO:0051179;fatty acid transport#GO:0015908;monocarboxylic acid transport#GO:0015718 organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;organelle membrane#GO:0031090;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;plasma membrane#GO:0005886;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cell periphery#GO:0071944;membrane#GO:0016020 secondary carrier transporter#PC00258 HUMAN|HGNC=10401|UniProtKB=P62269 P62269 RPS18 PTHR10871:SF42 30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18 SMALL RIBOSOMAL SUBUNIT PROTEIN US13 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;ribosome#GO:0005840;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;small ribosomal subunit#GO:0015935;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904 ribosomal protein#PC00202 HUMAN|HGNC=28268|UniProtKB=Q8N7N1 Q8N7N1 FAM86B1 PTHR14614:SF117 HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN PROTEIN-LYSINE N-METHYLTRANSFERASE EEF2KMT-RELATED lysine N-methyltransferase activity#GO:0016278;protein-lysine N-methyltransferase activity#GO:0016279;N-methyltransferase activity#GO:0008170;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;catalytic activity, acting on a protein#GO:0140096;protein methyltransferase activity#GO:0008276;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring one-carbon groups#GO:0016741 protein modifying enzyme#PC00260 HUMAN|HGNC=1653|UniProtKB=P10747 P10747 CD28 PTHR11494:SF7 CYTOTOXIC T-LYMPHOCYTE PROTEIN T-CELL-SPECIFIC SURFACE GLYCOPROTEIN CD28 regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;T cell receptor signaling pathway#GO:0050852;regulation of leukocyte cell-cell adhesion#GO:1903037;positive regulation of leukocyte proliferation#GO:0070665;positive regulation of cell activation#GO:0050867;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;positive regulation of leukocyte cell-cell adhesion#GO:1903039;multicellular organismal process#GO:0032501;regulation of lymphocyte proliferation#GO:0050670;regulation of cell adhesion#GO:0030155;positive regulation of response to stimulus#GO:0048584;positive regulation of cellular process#GO:0048522;regulation of cell population proliferation#GO:0042127;cell communication#GO:0007154;positive regulation of lymphocyte activation#GO:0051251;cell activation#GO:0001775;regulation of immune response#GO:0050776;positive regulation of lymphocyte proliferation#GO:0050671;immune response-activating cell surface receptor signaling pathway#GO:0002429;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of cell-cell adhesion#GO:0022407;regulation of T cell proliferation#GO:0042129;positive regulation of cell adhesion#GO:0045785;cellular response to stimulus#GO:0051716;leukocyte activation#GO:0045321;positive regulation of mononuclear cell proliferation#GO:0032946;immune response-activating signaling pathway#GO:0002757;regulation of leukocyte proliferation#GO:0070663;positive regulation of leukocyte activation#GO:0002696;cell surface receptor signaling pathway#GO:0007166;regulation of multicellular organismal process#GO:0051239;regulation of T cell activation#GO:0050863;lymphocyte activation#GO:0046649;positive regulation of T cell activation#GO:0050870;antigen receptor-mediated signaling pathway#GO:0050851;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;activation of immune response#GO:0002253;positive regulation of immune system process#GO:0002684;regulation of mononuclear cell proliferation#GO:0032944;positive regulation of cell-cell adhesion#GO:0022409;immune system process#GO:0002376;regulation of lymphocyte activation#GO:0051249;signaling#GO:0023052;positive regulation of T cell proliferation#GO:0042102;response to stimulus#GO:0050896;regulation of cell activation#GO:0050865;immune response-regulating signaling pathway#GO:0002764;positive regulation of multicellular organismal process#GO:0051240;regulation of biological process#GO:0050789;T cell activation#GO:0042110;regulation of leukocyte activation#GO:0002694;positive regulation of cell population proliferation#GO:0008284 membrane#GO:0016020;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;plasma membrane#GO:0005886 immunoglobulin receptor superfamily#PC00124 T cell activation#P00053>CD28#P01313 HUMAN|HGNC=18351|UniProtKB=B8ZZ34 B8ZZ34 SHISA8 PTHR31774:SF14 PROTEIN SHISA-9-RELATED PROTEIN SHISA-8 regulation of trans-synaptic signaling#GO:0099177;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;biological regulation#GO:0065007;modulation of chemical synaptic transmission#GO:0050804;regulation of biological process#GO:0050789;regulation of neuronal synaptic plasticity#GO:0048168;regulation of biological quality#GO:0065008;regulation of synaptic plasticity#GO:0048167;regulation of signaling#GO:0023051 membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane region#GO:0098590;postsynaptic specialization#GO:0099572;monoatomic ion channel complex#GO:0034702;neuron to neuron synapse#GO:0098984;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;neuron projection membrane#GO:0032589;signaling receptor complex#GO:0043235;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;asymmetric synapse#GO:0032279;plasma membrane bounded cell projection#GO:0120025;dendrite#GO:0030425;dendritic tree#GO:0097447;postsynaptic density#GO:0014069;transmembrane transporter complex#GO:1902495;cell leading edge#GO:0031252;neuron projection#GO:0043005;protein-containing complex#GO:0032991;synaptic membrane#GO:0097060;cell junction#GO:0030054;transporter complex#GO:1990351;postsynapse#GO:0098794;dendritic spine#GO:0043197;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;neuron spine#GO:0044309;postsynaptic membrane#GO:0045211;leading edge membrane#GO:0031256;cell projection membrane#GO:0031253 HUMAN|HGNC=29092|UniProtKB=O75147 O75147 OBSL1 PTHR35971:SF6 SI:DKEY-31G6.6 OBSCURIN-LIKE PROTEIN 1 cellular component organization or biogenesis#GO:0071840;regulation of anatomical structure morphogenesis#GO:0022603;microtubule-based process#GO:0007017;positive regulation of cell differentiation#GO:0045597;cytoskeleton organization#GO:0007010;regulation of multicellular organismal process#GO:0051239;positive regulation of cell development#GO:0010720;organelle organization#GO:0006996;regulation of neuron projection development#GO:0010975;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of cellular component organization#GO:0051130;regulation of cellular component organization#GO:0051128;positive regulation of nervous system development#GO:0051962;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;positive regulation of multicellular organismal process#GO:0051240;regulation of multicellular organismal development#GO:2000026;regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of cell projection organization#GO:0031344;positive regulation of developmental process#GO:0051094;regulation of cell differentiation#GO:0045595;biological regulation#GO:0065007;positive regulation of cellular process#GO:0048522;regulation of cell development#GO:0060284;microtubule cytoskeleton organization#GO:0000226;regulation of nervous system development#GO:0051960;positive regulation of cell projection organization#GO:0031346;regulation of dendrite development#GO:0050773;regulation of cellular process#GO:0050794;regulation of developmental process#GO:0050793;positive regulation of neurogenesis#GO:0050769;regulation of dendrite morphogenesis#GO:0048814;regulation of neurogenesis#GO:0050767 protein-containing complex#GO:0032991 HUMAN|HGNC=18942|UniProtKB=Q3SYF9 Q3SYF9 KRTAP19-7 PTHR38140:SF7 KERATIN-ASSOCIATED PROTEIN 19-3-RELATED KERATIN-ASSOCIATED PROTEIN 19-7 structural protein#PC00211 HUMAN|HGNC=6467|UniProtKB=Q86UP2 Q86UP2 KTN1 PTHR18864:SF1 KINECTIN KINECTIN HUMAN|HGNC=23440|UniProtKB=Q8NCK3 Q8NCK3 ZNF485 PTHR24393:SF100 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 345-RELATED transcription regulatory region nucleic acid binding#GO:0001067;transcription regulator activity#GO:0140110;DNA-binding transcription activator activity#GO:0001216;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;sequence-specific DNA binding#GO:0043565;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific double-stranded DNA binding#GO:1990837 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=17964|UniProtKB=Q8TC12 Q8TC12 RDH11 PTHR24320:SF306 RETINOL DEHYDROGENASE RETINOL DEHYDROGENASE 11 oxidoreductase activity#GO:0016491;alcohol dehydrogenase (NADP+) activity#GO:0008106;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455 primary metabolic process#GO:0044238;regulation of hormone levels#GO:0010817;small molecule metabolic process#GO:0044281;olefinic compound metabolic process#GO:0120254;retinol metabolic process#GO:0042572;terpenoid metabolic process#GO:0006721;isoprenoid metabolic process#GO:0006720;regulation of biological quality#GO:0065008;aldehyde metabolic process#GO:0006081;cellular process#GO:0009987;hormone metabolic process#GO:0042445;biological regulation#GO:0065007;metabolic process#GO:0008152;alcohol metabolic process#GO:0006066;lipid metabolic process#GO:0006629;retinoid metabolic process#GO:0001523;diterpenoid metabolic process#GO:0016101 organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;endoplasmic reticulum membrane#GO:0005789;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020 oxidoreductase#PC00176;dehydrogenase#PC00092 HUMAN|HGNC=27019|UniProtKB=Q5TZ20 Q5TZ20 OR2G6 PTHR26453:SF110 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2G6 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;nervous system process#GO:0050877;sensory perception#GO:0007600;system process#GO:0003008;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;detection of chemical stimulus#GO:0009593;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;response to stimulus#GO:0050896;response to chemical#GO:0042221 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=19836|UniProtKB=Q8N7A1 Q8N7A1 KLHDC1 PTHR46228:SF1 KELCH DOMAIN-CONTAINING PROTEIN KELCH DOMAIN-CONTAINING PROTEIN 1 HUMAN|HGNC=13721|UniProtKB=Q9Y256 Q9Y256 RCE1 PTHR13046:SF0 PROTEASE U48 CAAX PRENYL PROTEASE RCE1 CAAX PRENYL PROTEASE 2 metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604;protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;proteolysis#GO:0006508 membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020 metalloprotease#PC00153 HUMAN|HGNC=8646|UniProtKB=P61457 P61457 PCBD1 PTHR12599:SF13 PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE carbon-oxygen lyase activity#GO:0016835;lyase activity#GO:0016829;hydro-lyase activity#GO:0016836;catalytic activity#GO:0003824 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 lyase#PC00144;dehydratase#PC00091 HUMAN|HGNC=8789|UniProtKB=P18545 P18545 PDE6G PTHR12122:SF4 RETINAL CONE RHODOPSIN-SENSITIVE CGMP 3',5'-CYCLIC PHOSPHODIESTERASE GAMMA-SUBUNIT-RELATED ROD CGMP 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT GAMMA regulation of G protein-coupled receptor signaling pathway#GO:0008277;regulation of response to stimulus#GO:0048583;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of epidermal growth factor receptor signaling pathway#GO:0042058;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of cell communication#GO:0010646;positive regulation of signal transduction#GO:0009967;regulation of ERBB signaling pathway#GO:1901184;regulation of biological process#GO:0050789 organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;neuron projection#GO:0043005;cell periphery#GO:0071944;photoreceptor cell cilium#GO:0097733;9+0 non-motile cilium#GO:0097731;membrane#GO:0016020;plasma membrane#GO:0005886;ciliary membrane#GO:0060170;plasma membrane region#GO:0098590;cilium#GO:0005929;membrane-bounded organelle#GO:0043227;non-motile cilium#GO:0097730;cell projection membrane#GO:0031253;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;photoreceptor outer segment#GO:0001750;organelle#GO:0043226;cellular anatomical structure#GO:0110165 phosphodiesterase#PC00185 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>PDEgamma#P00754 HUMAN|HGNC=19113|UniProtKB=P59538 P59538 TAS2R31 PTHR11394:SF129 TASTE RECEPTOR TYPE 2 TASTE RECEPTOR TYPE 2 MEMBER 31 molecular transducer activity#GO:0060089;bitter taste receptor activity#GO:0033038;taste receptor activity#GO:0008527;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 detection of chemical stimulus#GO:0009593;sensory perception of bitter taste#GO:0050913;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;response to chemical#GO:0042221;response to stimulus#GO:0050896;multicellular organismal process#GO:0032501;sensory perception#GO:0007600;nervous system process#GO:0050877;detection of chemical stimulus involved in sensory perception of taste#GO:0050912;sensory perception of taste#GO:0050909;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;system process#GO:0003008;detection of chemical stimulus involved in sensory perception of bitter taste#GO:0001580 membrane#GO:0016020;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=2885|UniProtKB=P55073 P55073 DIO3 PTHR11781:SF4 IODOTHYRONINE DEIODINASE THYROXINE 5-DEIODINASE oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824 metabolic process#GO:0008152;regulation of biological quality#GO:0065008;phenol-containing compound metabolic process#GO:0018958;cellular process#GO:0009987;regulation of hormone levels#GO:0010817;modified amino acid metabolic process#GO:0006575;biological regulation#GO:0065007;hormone metabolic process#GO:0042445 metabolite interconversion enzyme#PC00262 HUMAN|HGNC=18242|UniProtKB=Q8NEU8 Q8NEU8 APPL2 PTHR46415:SF1 ADAPTOR PROTEIN, PHOSPHOTYROSINE INTERACTION, PH DOMAIN AND LEUCINE ZIPPER-CONTAINING 2 DCC-INTERACTING PROTEIN 13-BETA regulation of biological process#GO:0050789;biological regulation#GO:0065007;signaling#GO:0023052 membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endosome#GO:0005768;endosome membrane#GO:0010008;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;vesicle membrane#GO:0012506;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HUMAN|HGNC=9089|UniProtKB=O43660 O43660 PLRG1 PTHR19923:SF0 WD40 REPEAT PROTEINPRL1/PRL2-RELATED PLEIOTROPIC REGULATOR 1 mRNA splicing, via spliceosome#GO:0000398;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170 nucleus#GO:0005634;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Prp19 complex#GO:0000974;nuclear protein-containing complex#GO:0140513;catalytic step 2 spliceosome#GO:0071013 HUMAN|HGNC=20774|UniProtKB=P04350 P04350 TUBB4A PTHR11588:SF253 TUBULIN TUBULIN BETA-4A CHAIN structural constituent of cytoskeleton#GO:0005200;binding#GO:0005488;nucleoside phosphate binding#GO:1901265;guanyl nucleotide binding#GO:0019001;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167;structural molecule activity#GO:0005198;nucleotide binding#GO:0000166 microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;mitotic cell cycle#GO:0000278;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;cell cycle#GO:0007049;organelle organization#GO:0006996;cellular process#GO:0009987 microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;organelle#GO:0043226;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513 tubulin#PC00228;cytoskeletal protein#PC00085 Cytoskeletal regulation by Rho GTPase#P00016>tubulin#P00526;Huntington disease#P00029>Microtubule#P00780;Huntington disease#P00029>beta-Tubulin#P00790 HUMAN|HGNC=12652|UniProtKB=P50552 P50552 VASP PTHR11202:SF12 SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER VASODILATOR-STIMULATED PHOSPHOPROTEIN protein binding#GO:0005515;binding#GO:0005488 positive regulation of organelle organization#GO:0010638;positive regulation of cellular component organization#GO:0051130;generation of neurons#GO:0048699;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cellular component organization#GO:0016043;regulation of protein-containing complex assembly#GO:0043254;regulation of cellular component size#GO:0032535;embryonic morphogenesis#GO:0048598;morphogenesis of an epithelium#GO:0002009;cell projection morphogenesis#GO:0048858;plasma membrane bounded cell projection morphogenesis#GO:0120039;regulation of actin cytoskeleton organization#GO:0032956;cytoskeleton organization#GO:0007010;tissue morphogenesis#GO:0048729;system development#GO:0048731;supramolecular fiber organization#GO:0097435;actin cytoskeleton organization#GO:0030036;regulation of cytoskeleton organization#GO:0051493;regulation of protein polymerization#GO:0032271;tube morphogenesis#GO:0035239;regulation of supramolecular fiber organization#GO:1902903;cellular developmental process#GO:0048869;regulation of actin filament-based process#GO:0032970;developmental process#GO:0032502;tissue development#GO:0009888;regulation of actin filament polymerization#GO:0030833;positive regulation of protein polymerization#GO:0032273;tube development#GO:0035295;plasma membrane bounded cell projection organization#GO:0120036;regulation of actin polymerization or depolymerization#GO:0008064;axon development#GO:0061564;regulation of actin filament organization#GO:0110053;axonogenesis#GO:0007409;regulation of biological quality#GO:0065008;neuron development#GO:0048666;chordate embryonic development#GO:0043009;animal gross anatomical part developmental process#GO:0160108;regulation of actin filament length#GO:0030832;cell morphogenesis#GO:0000902;regulation of cellular component organization#GO:0051128;cell development#GO:0048468;regulation of cellular component biogenesis#GO:0044087;regulation of organelle organization#GO:0033043;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;anatomical structure formation involved in morphogenesis#GO:0048646;regulation of anatomical structure size#GO:0090066;neuron differentiation#GO:0030182;positive regulation of cellular component biogenesis#GO:0044089;nervous system development#GO:0007399;embryo development#GO:0009790;cell morphogenesis involved in neuron differentiation#GO:0048667;organelle organization#GO:0006996;neuron projection development#GO:0031175;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;anatomical structure development#GO:0048856;embryo development ending in birth or egg hatching#GO:0009792;actin filament-based process#GO:0030029;regulation of cellular process#GO:0050794;neurogenesis#GO:0022008;actin filament organization#GO:0007015;neuron projection guidance#GO:0097485;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;epithelium development#GO:0060429;biological regulation#GO:0065007;axon guidance#GO:0007411;actin polymerization or depolymerization#GO:0008154;positive regulation of cellular process#GO:0048522 anchoring junction#GO:0070161;cell junction#GO:0030054;cell-substrate junction#GO:0030055;plasma membrane#GO:0005886;focal adhesion#GO:0005925;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 scaffold/adaptor protein#PC00226 Integrin signalling pathway#P00034>VASP#P00934;Axon guidance mediated by netrin#P00009>Ena#P00361;Cytoskeletal regulation by Rho GTPase#P00016>Ena/VASP#P00516 HUMAN|HGNC=33892|UniProtKB=A6NJZ7 A6NJZ7 RIMBP3C PTHR14234:SF21 RIM BINDING PROTEIN-RELATED RIMS-BINDING PROTEIN 3A-RELATED protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488 male gamete generation#GO:0048232;cellular process#GO:0009987;cellular developmental process#GO:0048869;spermatogenesis#GO:0007283;developmental process#GO:0032502;cell differentiation#GO:0030154;gamete generation#GO:0007276;cell development#GO:0048468;fertilization#GO:0009566;reproductive process#GO:0022414;cellular process involved in reproduction in multicellular organism#GO:0022412;developmental process involved in reproduction#GO:0003006;germ cell development#GO:0007281;anatomical structure development#GO:0048856;multicellular organismal reproductive process#GO:0048609;spermatid differentiation#GO:0048515;sexual reproduction#GO:0019953;spermatid development#GO:0007286 microtubule cytoskeleton#GO:0015630;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 scaffold/adaptor protein#PC00226 HUMAN|HGNC=33983|UniProtKB=P0CG36 P0CG36 CFC1B PTHR14949:SF25 EGF-LIKE-DOMAIN, MULTIPLE 7, 8 CRYPTIC FAMILY PROTEIN 1B-RELATED signaling receptor binding#GO:0005102;receptor serine/threonine kinase binding#GO:0033612;binding#GO:0005488;protein binding#GO:0005515 vasculature development#GO:0001944;animal organ development#GO:0048513;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;developmental process#GO:0032502;left/right pattern formation#GO:0060972;specification of symmetry#GO:0009799;tube development#GO:0035295;determination of bilateral symmetry#GO:0009855;regionalization#GO:0003002;multicellular organismal process#GO:0032501;heart development#GO:0007507;vasculogenesis#GO:0001570;cellular process#GO:0009987;system development#GO:0048731;anatomical structure development#GO:0048856;pattern specification process#GO:0007389;animal gross anatomical part developmental process#GO:0160108;circulatory system development#GO:0072359;cell differentiation#GO:0030154;tube morphogenesis#GO:0035239;blood vessel development#GO:0001568;anatomical structure morphogenesis#GO:0009653;determination of left/right symmetry#GO:0007368;blood vessel morphogenesis#GO:0048514 extracellular region#GO:0005576;cell surface#GO:0009986;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HUMAN|HGNC=37453|UniProtKB=E5RHQ5 E5RHQ5 NPIPB11 PTHR15438:SF5 NUCLEAR PORE COMPLEX INTERACTING PROTEIN NUCLEAR PORE COMPLEX INTERACTING PROTEIN FAMILY MEMBER B3-RELATED HUMAN|HGNC=30002|UniProtKB=Q58WW2 Q58WW2 DCAF6 PTHR15574:SF39 WD REPEAT DOMAIN-CONTAINING FAMILY DDB1- AND CUL4-ASSOCIATED FACTOR 6 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription coactivator activity#GO:0003713 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of RNA metabolic process#GO:0051254;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of RNA metabolic process#GO:0051252 ubiquitin ligase complex#GO:0000151;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234;catalytic complex#GO:1902494;Cul4-RING E3 ubiquitin ligase complex#GO:0080008;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cullin-RING ubiquitin ligase complex#GO:0031461;cytoplasm#GO:0005737 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=28610|UniProtKB=Q8IWA6 Q8IWA6 CCDC60 PTHR34754:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 60 COILED-COIL DOMAIN-CONTAINING PROTEIN 60 HUMAN|HGNC=6147|UniProtKB=P38570 P38570 ITGAE PTHR23220:SF79 INTEGRIN ALPHA INTEGRIN ALPHA-E molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;integrin-mediated signaling pathway#GO:0007229;cell-cell adhesion#GO:0098609;cell-substrate adhesion#GO:0031589;cell communication#GO:0007154;cell-matrix adhesion#GO:0007160;cell adhesion#GO:0007155;cell surface receptor signaling pathway#GO:0007166 integrin complex#GO:0008305;signaling receptor complex#GO:0043235;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;plasma membrane#GO:0005886;membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;protein complex involved in cell adhesion#GO:0098636 integrin#PC00126;cell adhesion molecule#PC00069 Integrin signalling pathway#P00034>Integrin alpha#P00941 HUMAN|HGNC=26420|UniProtKB=Q86YE8 Q86YE8 ZNF573 PTHR24377:SF923 IP01015P-RELATED ZINC FINGER PROTEIN 573 double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=25652|UniProtKB=Q9H089 Q9H089 LSG1 PTHR45709:SF6 LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED LARGE SUBUNIT GTPASE 1 HOMOLOG hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity, acting on acid anhydrides#GO:0016817 establishment of organelle localization#GO:0051656;ribonucleoprotein complex biogenesis#GO:0022613;localization#GO:0051179;cellular localization#GO:0051641;nuclear transport#GO:0051169;nuclear export#GO:0051168;organelle localization#GO:0051640;ribosome biogenesis#GO:0042254;ribosome localization#GO:0033750;nucleocytoplasmic transport#GO:0006913;cellular component biogenesis#GO:0044085;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;ribosomal subunit export from nucleus#GO:0000054;intracellular transport#GO:0046907;transport#GO:0006810 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=18276|UniProtKB=P61619 P61619 SEC61A1 PTHR10906:SF19 SECY/SEC61-ALPHA FAMILY MEMBER PROTEIN TRANSPORT PROTEIN SEC61 SUBUNIT ALPHA ISOFORM 1 transmembrane protein transporter activity#GO:0008320;ribonucleoprotein complex binding#GO:0043021;ribosome binding#GO:0043022;protein-containing complex binding#GO:0044877;binding#GO:0005488;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 localization#GO:0051179;transmembrane transport#GO:0055085;cellular localization#GO:0051641;post-translational protein targeting to membrane, translocation#GO:0031204;protein transport#GO:0015031;localization within membrane#GO:0051668;post-translational protein targeting to endoplasmic reticulum membrane#GO:0006620;protein targeting#GO:0006605;establishment of protein localization to organelle#GO:0072594;intracellular protein transmembrane transport#GO:0065002;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;protein targeting to ER#GO:0045047;protein targeting to membrane#GO:0006612;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;SRP-dependent cotranslational protein targeting to membrane#GO:0006614;protein transmembrane transport#GO:0071806;transport#GO:0006810;establishment of protein localization to endoplasmic reticulum#GO:0072599;macromolecule localization#GO:0033036;establishment of protein localization to membrane#GO:0090150;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987 endoplasmic reticulum protein-containing complex#GO:0140534;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasm#GO:0005737;membrane#GO:0016020;rough endoplasmic reticulum#GO:0005791;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;rough endoplasmic reticulum membrane#GO:0030867;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796 transporter#PC00227 HUMAN|HGNC=944|UniProtKB=O60241 O60241 ADGRB2 PTHR12011:SF41 ADHESION G-PROTEIN COUPLED RECEPTOR ADHESION G PROTEIN-COUPLED RECEPTOR B2 transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023 cell communication#GO:0007154;anatomical structure development#GO:0048856;system development#GO:0048731;G protein-coupled receptor signaling pathway#GO:0007186;animal gross anatomical part developmental process#GO:0160108;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;peripheral nervous system development#GO:0007422;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;multicellular organism development#GO:0007275;developmental process#GO:0032502;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;nervous system development#GO:0007399;signal transduction#GO:0007165;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 p53 pathway#P00059>BAI-1#G04699 HUMAN|HGNC=23599|UniProtKB=Q6L8H1 Q6L8H1 KRTAP5-4 PTHR23262:SF242 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 5-4 structural protein#PC00211 HUMAN|HGNC=14587|UniProtKB=Q9NXR8 Q9NXR8 ING3 PTHR10333:SF114 INHIBITOR OF GROWTH PROTEIN INHIBITOR OF GROWTH PROTEIN 3 histone reader activity#GO:0140566;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;histone H3 reader activity#GO:0140006;chromatin-protein adaptor activity#GO:0140463 cellular process#GO:0009987;cellular component organization#GO:0016043;chromatin organization#GO:0006325;cellular component organization or biogenesis#GO:0071840 acetyltransferase complex#GO:1902493;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;protein acetyltransferase complex#GO:0031248;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;chromosome#GO:0005694;histone acetyltransferase complex#GO:0000123;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;transferase complex#GO:1990234;intracellular membraneless organelle#GO:0043232;NuA4 histone acetyltransferase complex#GO:0035267;H4 histone acetyltransferase complex#GO:1902562;protein-containing complex#GO:0032991;chromatin#GO:0000785;nucleus#GO:0005634 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=9944|UniProtKB=P35241 P35241 RDX PTHR23281:SF14 MERLIN/MOESIN/EZRIN/RADIXIN RADIXIN binding#GO:0005488;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;cell adhesion molecule binding#GO:0050839;protein binding#GO:0005515 regulation of protein localization#GO:0032880;regulation of biological quality#GO:0065008;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;regulation of cell shape#GO:0008360;regulation of organelle organization#GO:0033043;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of developmental process#GO:0050793;regulation of cellular component biogenesis#GO:0044087;regulation of anatomical structure morphogenesis#GO:0022603;regulation of transport#GO:0051049;regulation of localization#GO:0032879;regulation of organelle assembly#GO:1902115;positive regulation of transport#GO:0051050;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;actin cytoskeleton#GO:0015629;actin-based cell projection#GO:0098858;microvillus#GO:0005902;anchoring junction#GO:0070161;intracellular anatomical structure#GO:0005622;filopodium#GO:0030175;intracellular organelle#GO:0043229;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;membrane#GO:0016020;cell-cell junction#GO:0005911;cell periphery#GO:0071944;membraneless organelle#GO:0043228;cell junction#GO:0030054;adherens junction#GO:0005912;cytoskeleton#GO:0005856;apical part of cell#GO:0045177 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=28130|UniProtKB=Q8TB68 Q8TB68 PRR7 PTHR16209:SF3 VESICULAR, OVEREXPRESSED IN CANCER, PROSURVIVAL PROTEIN 1 PROLINE-RICH PROTEIN 7 cell communication#GO:0007154;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;synaptic signaling#GO:0099536 neuron to neuron synapse#GO:0098984;postsynaptic specialization#GO:0099572;intracellular membraneless organelle#GO:0043232;nucleus#GO:0005634;membraneless organelle#GO:0043228;cell junction#GO:0030054;synapse#GO:0045202;cellular anatomical structure#GO:0110165;asymmetric synapse#GO:0032279;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;postsynapse#GO:0098794;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;postsynaptic density#GO:0014069;intracellular organelle#GO:0043229 HUMAN|HGNC=3756|UniProtKB=Q14315 Q14315 FLNC PTHR38537:SF12 JITTERBUG, ISOFORM N FILAMIN-C HUMAN|HGNC=2978|UniProtKB=Q9Y6K1 Q9Y6K1 DNMT3A PTHR23068:SF10 DNA CYTOSINE-5- -METHYLTRANSFERASE 3-RELATED DNA (CYTOSINE-5)-METHYLTRANSFERASE 3A catalytic activity#GO:0003824;transferase activity#GO:0016740;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a nucleic acid#GO:0140640;methyltransferase activity#GO:0008168;catalytic activity, acting on DNA#GO:0140097 regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 DNA methyltransferase#PC00013 HUMAN|HGNC=2735|UniProtKB=Q13206 Q13206 DDX10 PTHR24031:SF775 RNA HELICASE ATP-DEPENDENT RNA HELICASE DDX10-RELATED nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;gene expression#GO:0010467 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 RNA helicase#PC00032;RNA metabolism protein#PC00031 HUMAN|HGNC=15857|UniProtKB=Q9NWU2 Q9NWU2 GID8 PTHR12864:SF85 RAN BINDING PROTEIN 9-RELATED GLUCOSE-INDUCED DEGRADATION PROTEIN 8 HOMOLOG protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of biological process#GO:0050789;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;positive regulation of signal transduction#GO:0009967;positive regulation of signaling#GO:0023056;protein metabolic process#GO:0019538;regulation of signaling#GO:0023051;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;proteasomal protein catabolic process#GO:0010498;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of Wnt signaling pathway#GO:0030177;positive regulation of response to stimulus#GO:0048584;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of canonical Wnt signaling pathway#GO:0060828;ubiquitin-dependent protein catabolic process#GO:0006511;positive regulation of canonical Wnt signaling pathway#GO:0090263;macromolecule metabolic process#GO:0043170;regulation of response to stimulus#GO:0048583;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;cytosol#GO:0005829;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;ubiquitin ligase complex#GO:0000151;intracellular organelle#GO:0043229;transferase complex#GO:1990234;catalytic complex#GO:1902494 scaffold/adaptor protein#PC00226 HUMAN|HGNC=12621|UniProtKB=Q9UPT9 Q9UPT9 USP22 PTHR21646:SF40 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 22 cysteine-type deubiquitinase activity#GO:0004843;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787 regulation of DNA-templated transcription#GO:0006355;regulation of biological quality#GO:0065008;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of protein stability#GO:0031647 cysteine protease#PC00081 HUMAN|HGNC=433|UniProtKB=P16050 P16050 ALOX15 PTHR11771:SF33 LIPOXYGENASE POLYUNSATURATED FATTY ACID LIPOXYGENASE ALOX15 dioxygenase activity#GO:0051213;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen#GO:0016702;catalytic activity#GO:0003824 lipid modification#GO:0030258;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;unsaturated fatty acid metabolic process#GO:0033559;lipid metabolic process#GO:0006629;icosanoid metabolic process#GO:0006690;long-chain fatty acid metabolic process#GO:0001676;cellular process#GO:0009987;lipid oxidation#GO:0034440;oxoacid metabolic process#GO:0043436;olefinic compound metabolic process#GO:0120254;small molecule metabolic process#GO:0044281;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;arachidonate metabolic process#GO:0019369 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829;membrane#GO:0016020;cell periphery#GO:0071944 oxygenase#PC00177;oxidoreductase#PC00176 Gonadotropin-releasing hormone receptor pathway#P06664>12-LO#P06815;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Lipoxygenase#P00830 HUMAN|HGNC=9674|UniProtKB=Q15262 Q15262 PTPRK PTHR19134:SF209 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE KAPPA phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824 anatomical structure development#GO:0048856;cell communication#GO:0007154;neuron development#GO:0048666;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell development#GO:0048468;signaling#GO:0023052;cellular component organization#GO:0016043;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;neurogenesis#GO:0022008;neuron differentiation#GO:0030182;developmental process#GO:0032502;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;nervous system development#GO:0007399;biological regulation#GO:0065007;neuron projection development#GO:0031175;cellular process#GO:0009987;signal transduction#GO:0007165 protein modifying enzyme#PC00260;protein phosphatase#PC00195 HUMAN|HGNC=4078|UniProtKB=P48169 P48169 GABRA4 PTHR18945:SF393 NEUROTRANSMITTER GATED ION CHANNEL GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-4 molecular transducer activity#GO:0060089;channel activity#GO:0015267;transmembrane signaling receptor activity#GO:0004888;gated channel activity#GO:0022836;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic ion channel activity#GO:0005216;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;monoatomic ion transmembrane transporter activity#GO:0015075;signaling receptor activity#GO:0038023;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;neurotransmitter receptor activity#GO:0030594;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 multicellular organismal process#GO:0032501;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;establishment of localization#GO:0051234;developmental process#GO:0032502;transport#GO:0006810;anterograde trans-synaptic signaling#GO:0098916;cell junction organization#GO:0034330;monoatomic anion transport#GO:0006820;chemical synaptic transmission#GO:0007268;chloride transmembrane transport#GO:1902476;cell communication#GO:0007154;localization#GO:0051179;anatomical structure development#GO:0048856;system development#GO:0048731;trans-synaptic signaling#GO:0099537;synapse organization#GO:0050808;cellular component assembly#GO:0022607;monoatomic anion transmembrane transport#GO:0098656;nervous system development#GO:0007399;cellular component biogenesis#GO:0044085;synaptic signaling#GO:0099536;cellular process#GO:0009987;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;chloride transport#GO:0006821;synapse assembly#GO:0007416;signaling#GO:0023052;cell junction assembly#GO:0034329;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;transmembrane transport#GO:0055085;inorganic anion transport#GO:0015698;monoatomic ion transport#GO:0006811;animal gross anatomical part developmental process#GO:0160108 cell projection membrane#GO:0031253;dendritic tree#GO:0097447;leading edge membrane#GO:0031256;dendrite#GO:0030425;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;synapse#GO:0045202;postsynapse#GO:0098794;cell junction#GO:0030054;neuron projection membrane#GO:0032589;signaling receptor complex#GO:0043235;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;protein-containing complex#GO:0032991;plasma membrane region#GO:0098590;cell periphery#GO:0071944;neuron projection#GO:0043005;membrane#GO:0016020;cell leading edge#GO:0031252 ligand-gated ion channel#PC00141 HUMAN|HGNC=24814|UniProtKB=A8MYZ6 A8MYZ6 FOXO6 PTHR45767:SF5 FORKHEAD BOX PROTEIN O FORKHEAD BOX PROTEIN O6 DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 winged helix/forkhead transcription factor#PC00246 HUMAN|HGNC=7562|UniProtKB=Q99836 Q99836 MYD88 PTHR15079:SF12 MYD88 MYELOID DIFFERENTIATION PRIMARY RESPONSE PROTEIN MYD88 protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488 defense response#GO:0006952;pattern recognition receptor signaling pathway#GO:0002221;positive regulation of response to biotic stimulus#GO:0002833;response to external stimulus#GO:0009605;innate immune response#GO:0045087;regulation of innate immune response#GO:0045088;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;positive regulation of defense response#GO:0031349;regulation of response to stress#GO:0080134;response to other organism#GO:0051707;immune response-regulating cell surface receptor signaling pathway#GO:0002768;toll-like receptor 4 signaling pathway#GO:0034142;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;positive regulation of innate immune response#GO:0045089;immune response#GO:0006955;activation of innate immune response#GO:0002218;cell communication#GO:0007154;regulation of defense response#GO:0031347;regulation of immune response#GO:0050776;response to bacterium#GO:0009617;immune response-activating cell surface receptor signaling pathway#GO:0002429;regulation of response to biotic stimulus#GO:0002831;response to external biotic stimulus#GO:0043207;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;innate immune response-activating signaling pathway#GO:0002758;positive regulation of response to external stimulus#GO:0032103;immune response-activating signaling pathway#GO:0002757;cell surface receptor signaling pathway#GO:0007166;defense response to other organism#GO:0098542;regulation of response to external stimulus#GO:0032101;cellular process#GO:0009987;defense response to symbiont#GO:0140546;activation of immune response#GO:0002253;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;response to stress#GO:0006950;positive regulation of immune system process#GO:0002684;response to biotic stimulus#GO:0009607;defense response to bacterium#GO:0042742;immune system process#GO:0002376;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;immune response-regulating signaling pathway#GO:0002764;regulation of biological process#GO:0050789;defense response to Gram-positive bacterium#GO:0050830 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 scaffold/adaptor protein#PC00226 Toll receptor signaling pathway#P00054>MyD88#P01377 HUMAN|HGNC=17268|UniProtKB=Q9H3R5 Q9H3R5 CENPH PTHR48122:SF1 CENTROMERE PROTEIN H CENTROMERE PROTEIN H binding#GO:0005488 microtubule-based process#GO:0007017;mitotic cell cycle process#GO:1903047;microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;spindle organization#GO:0007051;chromosome segregation#GO:0007059;cytoskeleton organization#GO:0007010;mitotic spindle organization#GO:0007052;mitotic cell cycle#GO:0000278;cellular process#GO:0009987;cell cycle process#GO:0022402;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cellular component organization#GO:0016043;cell cycle#GO:0007049;organelle organization#GO:0006996 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;kinetochore#GO:0000776;intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232;condensed chromosome, centromeric region#GO:0000779;nucleus#GO:0005634;membraneless organelle#GO:0043228;chromosome, centromeric region#GO:0000775;condensed chromosome#GO:0000793 HUMAN|HGNC=5739|UniProtKB=A0A075B6S9 A0A075B6S9 IGKV1-37 PTHR23267:SF468 IMMUNOGLOBULIN LIGHT CHAIN NON-FUNCTIONAL IMMUNOGLOBULIN KAPPA VARIABLE 1-37-RELATED response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=7678|UniProtKB=Q00604 Q00604 NDP PTHR28611:SF1 NORRIN NORRIN cytokine activity#GO:0005125;binding#GO:0005488;signaling receptor binding#GO:0005102;molecular function activator activity#GO:0140677;protein binding#GO:0005515;G protein-coupled receptor binding#GO:0001664;frizzled binding#GO:0005109;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546 cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;response to stimulus#GO:0050896;positive regulation of RNA metabolic process#GO:0051254;signaling#GO:0023052;regulation of DNA-templated transcription#GO:0006355;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;cell communication#GO:0007154;regulation of RNA metabolic process#GO:0051252;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;cell surface receptor signaling pathway#GO:0007166;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 HUMAN|HGNC=108|UniProtKB=P22303 P22303 ACHE PTHR11559:SF435 CARBOXYLESTERASE ACETYLCHOLINESTERASE hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;carboxylic ester hydrolase activity#GO:0052689 catabolic process#GO:0009056;metabolic process#GO:0008152;cellular process#GO:0009987 cell junction#GO:0030054;synapse#GO:0045202;cellular anatomical structure#GO:0110165 esterase#PC00097 Nicotinic acetylcholine receptor signaling pathway#P00044>AChE#P01093;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>AChE#P01067;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>AChE#P01080 HUMAN|HGNC=25292|UniProtKB=Q9H0M5 Q9H0M5 ZNF700 PTHR24379:SF40 KRAB AND ZINC FINGER DOMAIN-CONTAINING ZINC FINGER PROTEIN 700 transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=28673|UniProtKB=Q9BSK1 Q9BSK1 ZNF577 PTHR24377:SF900 IP01015P-RELATED ZINC FINGER PROTEIN 577 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=11029|UniProtKB=P48751 P48751 SLC4A3 PTHR11453:SF15 ANION EXCHANGE PROTEIN ANION EXCHANGE PROTEIN 3 monoatomic ion transmembrane transporter activity#GO:0015075;active transmembrane transporter activity#GO:0022804;chloride transmembrane transporter activity#GO:0015108;bicarbonate transmembrane transporter activity#GO:0015106;antiporter activity#GO:0015297;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;secondary active transmembrane transporter activity#GO:0015291;monoatomic anion transmembrane transporter activity#GO:0008509 regulation of intracellular pH#GO:0051453;regulation of pH#GO:0006885;regulation of biological quality#GO:0065008;localization#GO:0051179;transmembrane transport#GO:0055085;intracellular monoatomic ion homeostasis#GO:0006873;homeostatic process#GO:0042592;intracellular monoatomic cation homeostasis#GO:0030003;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;establishment of localization#GO:0051234;cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801;biological regulation#GO:0065007 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258 HUMAN|HGNC=53879|UniProtKB=Q6ZTK2 Q6ZTK2 APOLTP PTHR37860:SF2 AGAP008810-PA PROTEIN APOLTP HUMAN|HGNC=14249|UniProtKB=Q9NRE1 Q9NRE1 MMP26 PTHR10201:SF76 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE-26 peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 catabolic process#GO:0009056;cellular process#GO:0009987;cellular component organization#GO:0016043;external encapsulating structure organization#GO:0045229;cellular component organization or biogenesis#GO:0071840;extracellular matrix organization#GO:0030198;metabolic process#GO:0008152;extracellular structure organization#GO:0043062 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 metalloprotease#PC00153 HUMAN|HGNC=15136|UniProtKB=Q8NGI7 Q8NGI7 OR10V1 PTHR26452:SF263 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 10V1 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 sensory perception#GO:0007600;nervous system process#GO:0050877;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=26735|UniProtKB=Q2TAC6 Q2TAC6 KIF19 PTHR24115:SF434 KINESIN-RELATED KINESIN-LIKE PROTEIN KIF19 pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;tubulin binding#GO:0015631;macromolecular conformation isomerase activity#GO:0120543;isomerase activity#GO:0016853;ribonucleoside triphosphate phosphatase activity#GO:0017111;microtubule binding#GO:0008017;polypeptide conformation or assembly isomerase activity#GO:0120544;hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887;microtubule motor activity#GO:0003777;cytoskeletal protein binding#GO:0008092;hydrolase activity, acting on acid anhydrides#GO:0016817;cytoskeletal motor activity#GO:0003774;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;ATP-dependent activity#GO:0140657;protein binding#GO:0005515 cellular process#GO:0009987;microtubule-based movement#GO:0007018;microtubule-based process#GO:0007017 membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cytoskeleton#GO:0005856;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;supramolecular complex#GO:0099080;microtubule cytoskeleton#GO:0015630;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;microtubule#GO:0005874;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226 microtubule or microtubule-binding cytoskeletal protein#PC00157;microtubule binding motor protein#PC00156 HUMAN|HGNC=2933|UniProtKB=Q09013 Q09013 DMPK PTHR24356:SF392 SERINE/THREONINE-PROTEIN KINASE MYOTONIN-PROTEIN KINASE catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;regulation of heart contraction#GO:0008016;homeostatic process#GO:0042592;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;nuclear envelope organization#GO:0006998;calcium-mediated signaling#GO:0019722;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;nucleus organization#GO:0006997;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;regulation of system process#GO:0044057;membrane organization#GO:0061024;biological regulation#GO:0065007;inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;regulation of muscle contraction#GO:0006937;establishment or maintenance of cell polarity#GO:0007163;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;regulation of muscle system process#GO:0090257;intracellular monoatomic ion homeostasis#GO:0006873;intracellular calcium ion homeostasis#GO:0006874;cellular component organization or biogenesis#GO:0071840;chemical homeostasis#GO:0048878;intracellular signaling cassette#GO:0141124;regulation of multicellular organismal process#GO:0051239;endomembrane system organization#GO:0010256;cellular process#GO:0009987;signal transduction#GO:0007165;monoatomic ion homeostasis#GO:0050801;organelle organization#GO:0006996 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=24187|UniProtKB=Q9Y6J0 Q9Y6J0 CABIN1 PTHR15502:SF7 CALCINEURIN-BINDING PROTEIN CABIN 1-RELATED CALCINEURIN-BINDING PROTEIN CABIN-1 transcription coregulator activity#GO:0003712;binding#GO:0005488;transcription corepressor activity#GO:0003714;chromatin binding#GO:0003682;transcription regulator activity#GO:0140110;nucleosome binding#GO:0031491;protein-containing complex binding#GO:0044877 negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;negative regulation of metabolic process#GO:0009892;negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;chromatin organization#GO:0006325;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 phosphatase inhibitor#PC00183 HUMAN|HGNC=32695|UniProtKB=Q2VWA4 Q2VWA4 SKOR2 PTHR10005:SF7 SKI ONCOGENE-RELATED SKI FAMILY TRANSCRIPTIONAL COREPRESSOR 2 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;protein binding#GO:0005515;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 negative regulation of DNA-templated transcription#GO:0045892;negative regulation of cell communication#GO:0010648;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of signal transduction#GO:0009968;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of cell communication#GO:0010646;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of BMP signaling pathway#GO:0030514;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;negative regulation of response to stimulus#GO:0048585;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of biosynthetic process#GO:0009890;regulation of cellular response to growth factor stimulus#GO:0090287;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of BMP signaling pathway#GO:0030510;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605 intracellular anatomical structure#GO:0005622;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 HUMAN|HGNC=3017|UniProtKB=Q01658 Q01658 DR1 PTHR46138:SF1 PROTEIN DR1 PROTEIN DR1 binding#GO:0005488;transcription factor binding#GO:0008134;protein binding#GO:0005515 gene expression#GO:0010467;cellular component assembly#GO:0022607;protein-DNA complex assembly#GO:0065004;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;transcription initiation at RNA polymerase II promoter#GO:0006367;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein-DNA complex organization#GO:0071824;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-containing complex organization#GO:0043933;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;transcription by RNA polymerase II#GO:0006366;DNA-templated transcription initiation#GO:0006352;RNA polymerase II preinitiation complex assembly#GO:0051123;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;nucleic acid metabolic process#GO:0090304;protein-containing complex assembly#GO:0065003;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187 transcription repressor complex#GO:0017053;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226 HUMAN|HGNC=28779|UniProtKB=Q86WS5 Q86WS5 TMPRSS12 PTHR24253:SF146 TRANSMEMBRANE PROTEASE SERINE TRANSMEMBRANE PROTEASE SERINE 12 catalytic activity#GO:0003824;serine-type peptidase activity#GO:0008236;peptidase activity#GO:0008233;serine hydrolase activity#GO:0017171;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;proteolysis#GO:0006508;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein processing#GO:0016485 intracellular organelle#GO:0043229;acrosomal vesicle#GO:0001669;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;vesicle#GO:0031982;secretory vesicle#GO:0099503;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 protease#PC00190;serine protease#PC00203;protein modifying enzyme#PC00260 HUMAN|HGNC=28206|UniProtKB=Q9BSD3 Q9BSD3 RHNO1 PTHR35541:SF1 RAD9, HUS1, RAD1-INTERACTING NUCLEAR ORPHAN PROTEIN 1 RAD9, HUS1, RAD1-INTERACTING NUCLEAR ORPHAN PROTEIN 1 recombinational repair#GO:0000725;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of cell cycle phase transition#GO:1901987;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;DNA repair#GO:0006281;negative regulation of cellular process#GO:0048523;DNA damage response#GO:0006974;negative regulation of cell cycle process#GO:0010948;macromolecule metabolic process#GO:0043170;DNA integrity checkpoint signaling#GO:0031570;DNA damage checkpoint signaling#GO:0000077;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;cellular response to stress#GO:0033554;negative regulation of biological process#GO:0048519;negative regulation of cell cycle phase transition#GO:1901988;signal transduction in response to DNA damage#GO:0042770;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of cell cycle#GO:0051726;signaling#GO:0023052;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;DNA recombination#GO:0006310;negative regulation of cell cycle#GO:0045786;response to stress#GO:0006950;signal transduction#GO:0007165;cellular process#GO:0009987;cell cycle checkpoint signaling#GO:0000075;regulation of cell cycle process#GO:0010564 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694;nucleus#GO:0005634;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HUMAN|HGNC=28500|UniProtKB=Q8WW14 Q8WW14 SPMIP5 PTHR47301:SF1 HYPOTHETICAL PROTEIN LOC681006 SPERM-ASSOCIATED MICROTUBULE INNER PROTEIN 5 HUMAN|HGNC=14332|UniProtKB=Q9BXN6 Q9BXN6 SPANXD PTHR23425:SF16 NUCLEOPORIN AMO1-LIKE SPERM PROTEIN ASSOCIATED WITH THE NUCLEUS ON THE X CHROMOSOME A-RELATED transporter#PC00227 HUMAN|HGNC=20393|UniProtKB=Q8N9L1 Q8N9L1 ZIC4 PTHR19818:SF167 ZINC FINGER PROTEIN ZIC AND GLI ZINC FINGER PROTEIN ZIC 4 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;multicellular organism development#GO:0007275;developmental process#GO:0032502;nervous system development#GO:0007399;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;animal gross anatomical part developmental process#GO:0160108;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;central nervous system development#GO:0007417;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=14453|UniProtKB=Q9P0M6 Q9P0M6 MACROH2A2 PTHR23430:SF37 HISTONE H2A CORE HISTONE MACRO-H2A.2 structural molecule activity#GO:0005198 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;heterochromatin formation#GO:0031507;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of DNA-templated transcription#GO:0006355;regulation of transcription by RNA polymerase I#GO:0006356;regulation of RNA biosynthetic process#GO:2001141;chromatin organization#GO:0006325;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;epigenetic regulation of gene expression#GO:0040029;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of cellular process#GO:0048523;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;heterochromatin organization#GO:0070828;cellular component assembly#GO:0022607;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;negative regulation of gene expression, epigenetic#GO:0045814;cellular component organization or biogenesis#GO:0071840;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694;nucleosome#GO:0000786;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-DNA complex#GO:0032993;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=6849|UniProtKB=Q02779 Q02779 MAP3K10 PTHR44329:SF39 SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 10 protein serine/threonine kinase activity#GO:0004674;MAP kinase kinase kinase activity#GO:0004709;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096 response to stimulus#GO:0050896;positive regulation of programmed cell death#GO:0043068;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;regulation of programmed cell death#GO:0043067;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;positive regulation of apoptotic process#GO:0043065;cell communication#GO:0007154;regulation of apoptotic process#GO:0042981 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 Gonadotropin-releasing hormone receptor pathway#P06664>MAP3Ks#P06834;Huntington disease#P00029>MLK-2#P00764;p38 MAPK pathway#P05918>MLK2#P06028 HUMAN|HGNC=23511|UniProtKB=Q96M53 Q96M53 TBATA PTHR33772:SF3 THYMUS, BRAIN AND TESTES-ASSOCIATED PROTEIN TBATA HUMAN|HGNC=2339|UniProtKB=P29373 P29373 CRABP2 PTHR11955:SF152 FATTY ACID BINDING PROTEIN CELLULAR RETINOIC ACID-BINDING PROTEIN 2 binding#GO:0005488;small molecule binding#GO:0036094;carboxylic acid binding#GO:0031406;anion binding#GO:0043168;ion binding#GO:0043167;organic acid binding#GO:0043177;fatty acid binding#GO:0005504;lipid binding#GO:0008289 macromolecule localization#GO:0033036;lipid transport#GO:0006869;organic acid transport#GO:0015849;carboxylic acid transport#GO:0046942;transport#GO:0006810;lipid localization#GO:0010876;monocarboxylic acid transport#GO:0015718;fatty acid transport#GO:0015908;localization#GO:0051179;establishment of localization#GO:0051234 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cytosol#GO:0005829;nucleus#GO:0005634 transfer/carrier protein#PC00219 HUMAN|HGNC=3611|UniProtKB=P30273 P30273 FCER1G PTHR16803:SF0 HIGH AFFINITY IMMUNOGLOBULIN EPSILON RECEPTOR GAMMA-SUBUNIT HIGH AFFINITY IMMUNOGLOBULIN EPSILON RECEPTOR SUBUNIT GAMMA signaling receptor activity#GO:0038023;immune receptor activity#GO:0140375;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 regulation of response to stimulus#GO:0048583;response to external stimulus#GO:0009605;defense response#GO:0006952;innate immune response#GO:0045087;immune response#GO:0006955;immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007;adaptive immune response#GO:0002250;response to other organism#GO:0051707;regulation of immune response#GO:0050776;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;response to external biotic stimulus#GO:0043207;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;immune effector process#GO:0002252;signal transduction#GO:0007165;defense response to symbiont#GO:0140546;cellular process#GO:0009987;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;defense response to other organism#GO:0098542;immune system process#GO:0002376;immunoglobulin mediated immune response#GO:0016064;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449;regulation of biological process#GO:0050789;immune response-regulating signaling pathway#GO:0002764;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896 plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane#GO:0005886;cell surface#GO:0009986;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;external side of plasma membrane#GO:0009897;side of membrane#GO:0098552 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=2253|UniProtKB=Q9BR76 Q9BR76 CORO1B PTHR10856:SF24 CORONIN CORONIN-1B actin filament binding#GO:0051015;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 cellular component organization or biogenesis#GO:0071840;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;actin filament-based process#GO:0030029;actin cytoskeleton organization#GO:0030036;cell motility#GO:0048870;cell migration#GO:0016477;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987 actin filament#GO:0005884;cytoskeleton#GO:0005856;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;cell periphery#GO:0071944;cell leading edge#GO:0031252;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;supramolecular complex#GO:0099080;lamellipodium#GO:0030027;supramolecular polymer#GO:0099081;intracellular organelle#GO:0043229;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;actin cytoskeleton#GO:0015629;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165 non-motor actin binding protein#PC00165;cytoskeletal protein#PC00085 HUMAN|HGNC=9475|UniProtKB=P07477 P07477 PRSS1 PTHR24264:SF73 TRYPSIN-RELATED SERINE PROTEASE 1 catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;primary metabolic process#GO:0044238;metabolic process#GO:0008152;proteolysis#GO:0006508 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease#PC00190;serine protease#PC00203 HUMAN|HGNC=24693|UniProtKB=O94851 O94851 MICAL2 PTHR23167:SF39 CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED [F-ACTIN]-MONOOXYGENASE MICAL2 binding#GO:0005488;actin binding#GO:0003779;protein binding#GO:0005515;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen#GO:0016709;monooxygenase activity#GO:0004497;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;cytoskeletal protein binding#GO:0008092;oxidoreductase activity#GO:0016491 actin cytoskeleton organization#GO:0030036;cytoskeleton organization#GO:0007010;protein-containing complex disassembly#GO:0032984;protein depolymerization#GO:0051261;organelle organization#GO:0006996;cellular component organization#GO:0016043;actin filament depolymerization#GO:0030042;cellular process#GO:0009987;actin polymerization or depolymerization#GO:0008154;cellular component organization or biogenesis#GO:0071840;cellular component disassembly#GO:0022411;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;protein-containing complex organization#GO:0043933;actin filament-based process#GO:0030029 scaffold/adaptor protein#PC00226 HUMAN|HGNC=32697|UniProtKB=Q1XH10 Q1XH10 SKIDA1 PTHR23187:SF2 FLJ44216 PROTEIN-RELATED SKI_DACH DOMAIN-CONTAINING PROTEIN 1 HUMAN|HGNC=3594|UniProtKB=P49327 P49327 FASN PTHR43775:SF7 FATTY ACID SYNTHASE FATTY ACID SYNTHASE acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 fatty acid metabolic process#GO:0006631;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;monocarboxylic acid biosynthetic process#GO:0072330;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid biosynthetic process#GO:0046394;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;small molecule metabolic process#GO:0044281;biosynthetic process#GO:0009058;fatty acid biosynthetic process#GO:0006633 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=16829|UniProtKB=O43818 O43818 RRP9 PTHR19865:SF0 U3 SMALL NUCLEOLAR RNA INTERACTING PROTEIN 2 U3 SMALL NUCLEOLAR RNA-INTERACTING PROTEIN 2 nucleic acid binding#GO:0003676;binding#GO:0005488;snoRNA binding#GO:0030515;RNA binding#GO:0003723;U3 snoRNA binding#GO:0034511 cellular component biogenesis#GO:0044085;endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000479;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;biosynthetic process#GO:0009058;maturation of SSU-rRNA#GO:0030490;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;ribosomal small subunit biogenesis#GO:0042274;endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000447;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;maturation of 5.8S rRNA#GO:0000460;ribonucleoprotein complex biogenesis#GO:0022613;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364 protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;small-subunit processome#GO:0032040;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleolus#GO:0005730;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;preribosome#GO:0030684;intracellular organelle#GO:0043229 HUMAN|HGNC=15359|UniProtKB=P0C623 P0C623 OR4Q2 PTHR48002:SF127 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 4Q2 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=19437|UniProtKB=Q9NPC3 Q9NPC3 CCNB1IP1 PTHR14305:SF0 E3 UBIQUITIN-PROTEIN LIGASE CCNB1IP1 E3 UBIQUITIN-PROTEIN LIGASE CCNB1IP1 ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824 cell cycle process#GO:0022402;reciprocal homologous recombination#GO:0140527;nucleic acid metabolic process#GO:0090304;meiosis I#GO:0007127;meiotic cell cycle process#GO:1903046;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;cell cycle#GO:0007049;reproductive process#GO:0022414;homologous recombination#GO:0035825;reciprocal meiotic recombination#GO:0007131;sexual reproduction#GO:0019953;nuclear division#GO:0000280;meiosis I cell cycle process#GO:0061982;organelle fission#GO:0048285;cellular process#GO:0009987;organelle organization#GO:0006996;nucleobase-containing compound metabolic process#GO:0006139;DNA recombination#GO:0006310;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;meiotic cell cycle#GO:0051321;meiotic nuclear division#GO:0140013;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840 nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;synaptonemal structure#GO:0099086;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;synaptonemal complex#GO:0000795;condensed nuclear chromosome#GO:0000794;membraneless organelle#GO:0043228;condensed chromosome#GO:0000793;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=20603|UniProtKB=Q86SQ9 Q86SQ9 DHDDS PTHR10291:SF51 DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT DHDDS catalytic activity#GO:0003824;transferase activity#GO:0016740;prenyltransferase activity#GO:0004659;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765 metabolic process#GO:0008152;alcohol metabolic process#GO:0006066;lipid metabolic process#GO:0006629;isoprenoid biosynthetic process#GO:0008299;small molecule biosynthetic process#GO:0044283;isoprenoid metabolic process#GO:0006720;primary metabolic process#GO:0044238;alcohol biosynthetic process#GO:0046165;cellular process#GO:0009987;small molecule metabolic process#GO:0044281;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle#GO:0043229 acyltransferase#PC00042 HUMAN|HGNC=4688|UniProtKB=P25092 P25092 GUCY2C PTHR11920:SF347 GUANYLYL CYCLASE GUANYLYL CYCLASE C molecular transducer activity#GO:0060089;lyase activity#GO:0016829;cyclase activity#GO:0009975;phosphorus-oxygen lyase activity#GO:0016849;catalytic activity#GO:0003824;signaling receptor activity#GO:0038023;guanylate cyclase activity#GO:0004383;peptide receptor activity#GO:0001653 primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;nucleoside phosphate metabolic process#GO:0006753;cell communication#GO:0007154;cGMP biosynthetic process#GO:0006182;organophosphate biosynthetic process#GO:0090407;enzyme-linked receptor protein signaling pathway#GO:0007167;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;carbohydrate derivative metabolic process#GO:1901135;cGMP metabolic process#GO:0046068;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;cyclic nucleotide metabolic process#GO:0009187;nucleoside phosphate biosynthetic process#GO:1901293;phosphorus metabolic process#GO:0006793;regulation of biological process#GO:0050789;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;response to stimulus#GO:0050896;small molecule metabolic process#GO:0044281;signaling#GO:0023052;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;ribonucleotide metabolic process#GO:0009259;cyclic nucleotide biosynthetic process#GO:0009190;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;nucleotide biosynthetic process#GO:0009165;ribose phosphate biosynthetic process#GO:0046390;signal transduction#GO:0007165;receptor guanylyl cyclase signaling pathway#GO:0007168;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;cyclic purine nucleotide metabolic process#GO:0052652;cell surface receptor signaling pathway#GO:0007166;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 lyase#PC00144;guanylate cyclase#PC00114 HUMAN|HGNC=12483|UniProtKB=P60604 P60604 UBE2G2 PTHR24067:SF154 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2 G2 catalytic activity, acting on a protein#GO:0140096;ubiquitin conjugating enzyme activity#GO:0061631;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-like protein conjugating enzyme activity#GO:0061650;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787 response to stimulus#GO:0050896;catabolic process#GO:0009056;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;protein polyubiquitination#GO:0000209;cellular response to stimulus#GO:0051716;protein modification process#GO:0036211;primary metabolic process#GO:0044238;ERAD pathway#GO:0036503;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;modification-dependent macromolecule catabolic process#GO:0043632;protein modification by small protein conjugation or removal#GO:0070647;response to endoplasmic reticulum stress#GO:0034976;protein ubiquitination#GO:0016567;proteasomal protein catabolic process#GO:0010498;post-translational protein modification#GO:0043687;response to chemical#GO:0042221;cellular process#GO:0009987;response to stress#GO:0006950;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein K48-linked ubiquitination#GO:0070936;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 Ubiquitin proteasome pathway#P00060>E2#P01491;Parkinson disease#P00049>Ubc7#P01220 HUMAN|HGNC=28766|UniProtKB=Q8N823 Q8N823 ZNF611 PTHR24377:SF741 IP01015P-RELATED ZINC FINGER PROTEIN 611 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=4373|UniProtKB=P60983 P60983 GMFB PTHR11249:SF3 GLIAL FACTOR NATURATION FACTOR GLIA MATURATION FACTOR BETA protein-containing complex binding#GO:0044877;binding#GO:0005488 regulation of actin nucleation#GO:0051125;negative regulation of cellular process#GO:0048523;regulation of actin filament-based process#GO:0032970;biological regulation#GO:0065007;regulation of actin cytoskeleton organization#GO:0032956;cellular process#GO:0009987;regulation of actin filament organization#GO:0110053;negative regulation of cytoskeleton organization#GO:0051494;actin filament-based process#GO:0030029;regulation of cellular component organization#GO:0051128;negative regulation of supramolecular fiber organization#GO:1902904;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794;regulation of supramolecular fiber organization#GO:1902903;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;negative regulation of biological process#GO:0048519;negative regulation of organelle organization#GO:0010639;negative regulation of cellular component organization#GO:0051129 intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;cell cortex#GO:0005938;cell periphery#GO:0071944;actin cytoskeleton#GO:0015629;cortical cytoskeleton#GO:0030863;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;cortical actin cytoskeleton#GO:0030864;organelle#GO:0043226;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HUMAN|HGNC=10592|UniProtKB=Q8IWT1 Q8IWT1 SCN4B PTHR13869:SF14 MYELIN P0 RELATED SODIUM CHANNEL REGULATORY SUBUNIT BETA-4 ion channel regulator activity#GO:0099106;binding#GO:0005488;transmembrane transporter binding#GO:0044325;transporter regulator activity#GO:0141108;protein binding#GO:0005515;channel regulator activity#GO:0016247;molecular function regulator activity#GO:0098772 actin filament-based movement#GO:0030048;cellular process#GO:0009987;biological regulation#GO:0065007;regulation of multicellular organismal process#GO:0051239;blood circulation#GO:0008015;cardiac muscle cell action potential involved in contraction#GO:0086002;multicellular organismal process#GO:0032501;muscle contraction#GO:0006936;regulation of system process#GO:0044057;heart contraction#GO:0060047;system process#GO:0003008;regulation of membrane potential#GO:0042391;cardiac muscle cell contraction#GO:0086003;muscle system process#GO:0003012;regulation of biological process#GO:0050789;action potential#GO:0001508;heart process#GO:0003015;striated muscle contraction#GO:0006941;membrane depolarization#GO:0051899;regulation of heart contraction#GO:0008016;actin-mediated cell contraction#GO:0070252;cardiac muscle contraction#GO:0060048;actin filament-based process#GO:0030029;circulatory system process#GO:0003013;regulation of biological quality#GO:0065008 cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;cation channel complex#GO:0034703;sodium channel complex#GO:0034706;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495 myelin protein#PC00161 HUMAN|HGNC=16006|UniProtKB=Q9H175 Q9H175 CSRNP2 PTHR13580:SF6 TGF-BETA INDUCED APOPTOSIS PROTEIN CYSTEINE_SERINE-RICH NUCLEAR PROTEIN 2 transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=7860|UniProtKB=Q16517 Q16517 NNAT PTHR15285:SF0 NEURONATIN NEURONATIN regulation of protein transport#GO:0051223;cell differentiation#GO:0030154;regulation of hormone levels#GO:0010817;regulation of biological process#GO:0050789;regulation of secretion by cell#GO:1903530;regulation of biological quality#GO:0065008;regulation of protein localization#GO:0032880;positive regulation of signaling#GO:0023056;regulation of hormone secretion#GO:0046883;regulation of signaling#GO:0023051;generation of neurons#GO:0048699;positive regulation of secretion#GO:0051047;animal gross anatomical part developmental process#GO:0160108;nervous system development#GO:0007399;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of secretion by cell#GO:1903532;positive regulation of transport#GO:0051050;regulation of insulin secretion#GO:0050796;regulation of localization#GO:0032879;regulation of transport#GO:0051049;positive regulation of protein secretion#GO:0050714;multicellular organism development#GO:0007275;neuron differentiation#GO:0030182;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of protein secretion#GO:0050708;regulation of establishment of protein localization#GO:0070201;system development#GO:0048731;anatomical structure development#GO:0048856;regulation of secretion#GO:0051046;positive regulation of hormone secretion#GO:0046887;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;positive regulation of cellular process#GO:0048522;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;developmental process#GO:0032502 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=15629|UniProtKB=Q9NY97 Q9NY97 B3GNT2 PTHR11214:SF25 BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE N-ACETYLLACTOSAMINIDE BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE 2 transferase activity#GO:0016740;catalytic activity#GO:0003824;hexosyltransferase activity#GO:0016758;glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194;acetylglucosaminyltransferase activity#GO:0008375 macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;metabolic process#GO:0008152;aminoglycan metabolic process#GO:0006022;biosynthetic process#GO:0009058;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;aminoglycan biosynthetic process#GO:0006023 Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 transferase#PC00220;glycosyltransferase#PC00111 HUMAN|HGNC=197|UniProtKB=Q9H013 Q9H013 ADAM19 PTHR11905:SF19 ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 19 metalloendopeptidase activity#GO:0004222;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;proteolysis#GO:0006508;membrane protein ectodomain proteolysis#GO:0006509;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;membrane protein proteolysis#GO:0033619;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein processing#GO:0016485 protease#PC00190;metalloprotease#PC00153 HUMAN|HGNC=29508|UniProtKB=Q9ULH0 Q9ULH0 KIDINS220 PTHR24116:SF0 KINASE D-INTERACTING SUBSTRATE OF 220 KDA KINASE D-INTERACTING SUBSTRATE OF 220 KDA enzyme regulator activity#GO:0030234;protein kinase regulator activity#GO:0019887;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;response to endogenous stimulus#GO:0009719;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;response to growth factor#GO:0070848;cell surface receptor signaling pathway#GO:0007166;cellular response to growth factor stimulus#GO:0071363;cellular response to nerve growth factor stimulus#GO:1990090;cell communication#GO:0007154 cell junction#GO:0030054;synapse#GO:0045202;cellular anatomical structure#GO:0110165 HUMAN|HGNC=16721|UniProtKB=A6NKQ9 A6NKQ9 CGB1 PTHR11515:SF25 GLYCOPROTEIN HORMONE BETA CHAIN CHORIOGONADOTROPIN SUBUNIT BETA 3-RELATED molecular function regulator activity#GO:0098772;hormone activity#GO:0005179;signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545 anatomical structure development#GO:0048856;cell communication#GO:0007154;reproductive system development#GO:0061458;system development#GO:0048731;female gonad development#GO:0008585;animal gross anatomical part developmental process#GO:0160108;G protein-coupled receptor signaling pathway#GO:0007186;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;reproductive structure development#GO:0048608;reproductive process#GO:0022414;signaling#GO:0023052;developmental process involved in reproduction#GO:0003006;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;animal organ development#GO:0048513;multicellular organism development#GO:0007275;developmental process#GO:0032502;development of primary sexual characteristics#GO:0045137;multicellular organismal process#GO:0032501;gonad development#GO:0008406;biological regulation#GO:0065007;cellular process#GO:0009987;sex differentiation#GO:0007548;signal transduction#GO:0007165 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 peptide hormone#PC00179 HUMAN|HGNC=25885|UniProtKB=Q9H7R5 Q9H7R5 ZNF665 PTHR24377:SF1043 IP01015P-RELATED ZINC FINGER PROTEIN 160-RELATED cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=11167|UniProtKB=Q13424 Q13424 SNTA1 PTHR10554:SF6 SYNTROPHIN ALPHA-1-SYNTROPHIN transporter regulator activity#GO:0141108;ion channel regulator activity#GO:0099106;molecular function regulator activity#GO:0098772;channel regulator activity#GO:0016247 actin filament-based process#GO:0030029;cardiac muscle contraction#GO:0060048;circulatory system process#GO:0003013;regulation of biological quality#GO:0065008;heart process#GO:0003015;muscle system process#GO:0003012;action potential#GO:0001508;striated muscle contraction#GO:0006941;actin-mediated cell contraction#GO:0070252;muscle contraction#GO:0006936;system process#GO:0003008;heart contraction#GO:0060047;cardiac muscle cell contraction#GO:0086003;regulation of membrane potential#GO:0042391;actin filament-based movement#GO:0030048;cellular process#GO:0009987;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;blood circulation#GO:0008015;cardiac muscle cell action potential involved in contraction#GO:0086002 membrane protein complex#GO:0098796;dystrophin-associated glycoprotein complex#GO:0016010;membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;cellular anatomical structure#GO:0110165;synapse#GO:0045202;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;sarcolemma#GO:0042383;cell junction#GO:0030054;neuromuscular junction#GO:0031594 scaffold/adaptor protein#PC00226 HUMAN|HGNC=16187|UniProtKB=Q9NQ40 Q9NQ40 SLC52A3 PTHR12929:SF4 SOLUTE CARRIER FAMILY 52 SOLUTE CARRIER FAMILY 52, RIBOFLAVIN TRANSPORTER, MEMBER 3 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 transport#GO:0006810;nitrogen compound transport#GO:0071705;localization#GO:0051179;establishment of localization#GO:0051234;vitamin transport#GO:0051180 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258 HUMAN|HGNC=4185|UniProtKB=Q14549 Q14549 GBX1 PTHR24334:SF2 HOMEOBOX PROTEIN GBX HOMEOBOX PROTEIN GBX-1 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of nervous system development#GO:0051960;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of multicellular organismal development#GO:2000026;regulation of biological process#GO:0050789 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 homeodomain transcription factor#PC00119 HUMAN|HGNC=18292|UniProtKB=P0CG37 P0CG37 CFC1 PTHR14949:SF25 EGF-LIKE-DOMAIN, MULTIPLE 7, 8 CRYPTIC FAMILY PROTEIN 1B-RELATED signaling receptor binding#GO:0005102;binding#GO:0005488;receptor serine/threonine kinase binding#GO:0033612;protein binding#GO:0005515 blood vessel morphogenesis#GO:0048514;blood vessel development#GO:0001568;tube morphogenesis#GO:0035239;determination of left/right symmetry#GO:0007368;anatomical structure morphogenesis#GO:0009653;circulatory system development#GO:0072359;cell differentiation#GO:0030154;animal gross anatomical part developmental process#GO:0160108;pattern specification process#GO:0007389;anatomical structure development#GO:0048856;system development#GO:0048731;cellular process#GO:0009987;regionalization#GO:0003002;multicellular organismal process#GO:0032501;vasculogenesis#GO:0001570;heart development#GO:0007507;tube development#GO:0035295;determination of bilateral symmetry#GO:0009855;specification of symmetry#GO:0009799;left/right pattern formation#GO:0060972;developmental process#GO:0032502;animal organ development#GO:0048513;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;vasculature development#GO:0001944 extracellular region#GO:0005576;cell surface#GO:0009986;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 HUMAN|HGNC=19973|UniProtKB=Q8TCX5 Q8TCX5 RHPN1 PTHR23031:SF6 RHOPHILIN RHOPHILIN-1 negative regulation of cytoskeleton organization#GO:0051494;negative regulation of biological process#GO:0048519;regulation of actin filament bundle assembly#GO:0032231;negative regulation of organelle organization#GO:0010639;negative regulation of cellular component organization#GO:0051129;regulation of biological process#GO:0050789;regulation of supramolecular fiber organization#GO:1902903;regulation of organelle organization#GO:0033043;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;negative regulation of supramolecular fiber organization#GO:1902904;regulation of cellular process#GO:0050794;regulation of stress fiber assembly#GO:0051492;regulation of cellular component biogenesis#GO:0044087;regulation of actin filament-based process#GO:0032970;negative regulation of cellular process#GO:0048523;regulation of actin filament organization#GO:0110053;biological regulation#GO:0065007;regulation of actin cytoskeleton organization#GO:0032956 scaffold/adaptor protein#PC00226 HUMAN|HGNC=17778|UniProtKB=A6NER3 A6NER3 GAGE12J PTHR14047:SF30 P ANTIGEN FAMILY MEMBER 5-RELATED G ANTIGEN 1-RELATED HUMAN|HGNC=52384|UniProtKB=A0A0U1RRK4 A0A0U1RRK4 LBHD2 PTHR14987:SF3 PROTEIN LBH-RELATED LBH DOMAIN-CONTAINING PROTEIN 2 HUMAN|HGNC=9532|UniProtKB=P25788 P25788 PSMA3 PTHR11599:SF10 PROTEASOME SUBUNIT ALPHA/BETA PROTEASOME SUBUNIT ALPHA TYPE-3 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941 catalytic complex#GO:1902494;intracellular organelle#GO:0043229;endopeptidase complex#GO:1905369;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;proteasome complex#GO:0000502;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;peptidase complex#GO:1905368;intracellular membrane-bounded organelle#GO:0043231 protein modifying enzyme#PC00260;protease#PC00190 Parkinson disease#P00049>20S proteasome#P01227 HUMAN|HGNC=33940|UniProtKB=P0C0P6 P0C0P6 NPS PTHR36679:SF1 NEUROPEPTIDE S NEUROPEPTIDE S biological regulation#GO:0065007;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of trans-synaptic signaling#GO:0099177;positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789;positive regulation of cellular process#GO:0048522;regulation of biological quality#GO:0065008;regulation of synaptic transmission, glutamatergic#GO:0051966;regulation of membrane potential#GO:0042391;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;positive regulation of synaptic transmission#GO:0050806 HUMAN|HGNC=223|UniProtKB=Q9UKP4 Q9UKP4 ADAMTS7 PTHR13723:SF142 ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 7 catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233 external encapsulating structure organization#GO:0045229;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;extracellular matrix organization#GO:0030198;protein metabolic process#GO:0019538;metabolic process#GO:0008152;proteolysis#GO:0006508;extracellular structure organization#GO:0043062;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization#GO:0016043 cellular anatomical structure#GO:0110165;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576 metalloprotease#PC00153 HUMAN|HGNC=8516|UniProtKB=Q6ZRI0 Q6ZRI0 OTOG PTHR11339:SF228 EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED OTOGELIN extracellular matrix structural constituent#GO:0005201;structural molecule activity#GO:0005198 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 extracellular matrix protein#PC00102 HUMAN|HGNC=20489|UniProtKB=Q96FK6 Q96FK6 WDR89 PTHR22889:SF0 WD REPEAT-CONTAINING PROTEIN 89 WD REPEAT-CONTAINING PROTEIN 89 HUMAN|HGNC=25984|UniProtKB=Q8NE00 Q8NE00 SLC38A12 PTHR16189:SF0 TRANSMEMBRANE PROTEIN 104-RELATED SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 12-RELATED HUMAN|HGNC=25674|UniProtKB=Q9HAF1 Q9HAF1 MEAF6 PTHR13476:SF0 CHROMATIN MODIFICATION-RELATED PROTEIN MEAF6 CHROMATIN MODIFICATION-RELATED PROTEIN MEAF6 transferase complex#GO:1990234;histone acetyltransferase complex#GO:0000123;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;chromatin#GO:0000785;intracellular membraneless organelle#GO:0043232;NuA4 histone acetyltransferase complex#GO:0035267;H4 histone acetyltransferase complex#GO:1902562;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;protein acetyltransferase complex#GO:0031248;acetyltransferase complex#GO:1902493;intracellular anatomical structure#GO:0005622;chromosome#GO:0005694;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=436|UniProtKB=P20292 P20292 ALOX5AP PTHR10250:SF2 MICROSOMAL GLUTATHIONE S-TRANSFERASE ARACHIDONATE 5-LIPOXYGENASE-ACTIVATING PROTEIN peroxidase activity#GO:0004601;antioxidant activity#GO:0016209;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765;oxidoreductase activity#GO:0016491;glutathione transferase activity#GO:0004364;lyase activity#GO:0016829;carbon-sulfur lyase activity#GO:0016846;oxidoreductase activity, acting on peroxide as acceptor#GO:0016684 small molecule biosynthetic process#GO:0044283;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;cellular process#GO:0009987;carboxylic acid biosynthetic process#GO:0046394;carboxylic acid metabolic process#GO:0019752;biosynthetic process#GO:0009058;icosanoid biosynthetic process#GO:0046456;icosanoid metabolic process#GO:0006690;small molecule metabolic process#GO:0044281 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle envelope#GO:0031967;nucleus#GO:0005634;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nuclear envelope#GO:0005635 transferase#PC00220 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Lipoxygenase#P00830 HUMAN|HGNC=12566|UniProtKB=O14795 O14795 UNC13B PTHR10480:SF8 PROTEIN UNC-13 HOMOLOG PROTEIN UNC-13 HOMOLOG B binding#GO:0005488;SNARE binding#GO:0000149;calmodulin binding#GO:0005516;protein binding#GO:0005515;syntaxin binding#GO:0019905 cellular localization#GO:0051641;secretion by cell#GO:0032940;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;protein-containing complex assembly#GO:0065003;establishment of organelle localization#GO:0051656;export from cell#GO:0140352;signaling#GO:0023052;regulated exocytosis#GO:0045055;exocytic process#GO:0140029;cellular component organization or biogenesis#GO:0071840;vesicle-mediated transport in synapse#GO:0099003;exocytosis#GO:0006887;protein-containing complex organization#GO:0043933;cellular component biogenesis#GO:0044085;synaptic signaling#GO:0099536;synaptic vesicle exocytosis#GO:0016079;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;cellular component assembly#GO:0022607;vesicle-mediated transport#GO:0016192;neurotransmitter transport#GO:0006836;synaptic transmission, glutamatergic#GO:0035249;establishment of vesicle localization#GO:0051650;signal release#GO:0023061;trans-synaptic signaling#GO:0099537;organelle localization#GO:0051640;cell communication#GO:0007154;localization#GO:0051179;secretion#GO:0046903;chemical synaptic transmission#GO:0007268;signal release from synapse#GO:0099643;anterograde trans-synaptic signaling#GO:0098916;calcium-ion regulated exocytosis#GO:0017156;synaptic vesicle cycle#GO:0099504;transport#GO:0006810;establishment of localization#GO:0051234;vesicle localization#GO:0051648;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;neurotransmitter secretion#GO:0007269 cell junction#GO:0030054;bounding membrane of organelle#GO:0098588;synaptic membrane#GO:0097060;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;secretory vesicle#GO:0099503;neuron projection#GO:0043005;presynapse#GO:0098793;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cell projection#GO:0042995;intracellular vesicle#GO:0097708;neuromuscular junction#GO:0031594;organelle membrane#GO:0031090;axon terminus#GO:0043679;endomembrane system#GO:0012505;transport vesicle membrane#GO:0030658;transport vesicle#GO:0030133;plasma membrane region#GO:0098590;presynaptic membrane#GO:0042734;plasma membrane#GO:0005886;membrane#GO:0016020;vesicle membrane#GO:0012506;cell periphery#GO:0071944;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;axon#GO:0030424;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;distal axon#GO:0150034;terminal bouton#GO:0043195;neuron projection terminus#GO:0044306;synaptic vesicle#GO:0008021;synaptic vesicle membrane#GO:0030672;vesicle#GO:0031982 Synaptic vesicle trafficking#P05734>Munc13#P05773 HUMAN|HGNC=14652|UniProtKB=Q9NVD7 Q9NVD7 PARVA PTHR12114:SF6 PARVIN ALPHA-PARVIN binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;protein binding#GO:0005515 regulation of anatomical structure morphogenesis#GO:0022603;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection assembly#GO:0120031;substrate adhesion-dependent cell spreading#GO:0034446;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cell projection assembly#GO:0030031;cell-substrate adhesion#GO:0031589;regulation of biological quality#GO:0065008;cilium organization#GO:0044782;organelle assembly#GO:0070925;establishment or maintenance of cell polarity#GO:0007163;actin filament-based process#GO:0030029;cell adhesion#GO:0007155;actin cytoskeleton organization#GO:0030036;cell projection organization#GO:0030030;regulation of developmental process#GO:0050793;cilium assembly#GO:0060271;cellular component organization#GO:0016043;regulation of cell shape#GO:0008360;regulation of biological process#GO:0050789 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;cell junction#GO:0030054;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;actin cytoskeleton#GO:0015629;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cell-substrate junction#GO:0030055;focal adhesion#GO:0005925;cytoplasm#GO:0005737 actin and actin related protein#PC00039;actin or actin-binding cytoskeletal protein#PC00041 Integrin signalling pathway#P00034>Parvin#P00945 HUMAN|HGNC=739|UniProtKB=Q99929 Q99929 ASCL2 PTHR13935:SF62 ACHAETE-SCUTE TRANSCRIPTION FACTOR-RELATED ACHAETE-SCUTE HOMOLOG 2 double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;regulation of multicellular organismal process#GO:0051239;nervous system development#GO:0007399;positive regulation of transcription by RNA polymerase II#GO:0045944;neuron differentiation#GO:0030182;multicellular organism development#GO:0007275;animal organ development#GO:0048513;regulation of biological process#GO:0050789;regulation of multicellular organismal development#GO:2000026;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;regulation of cell development#GO:0060284;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;sensory organ development#GO:0007423;developmental process#GO:0032502;regulation of cell differentiation#GO:0045595;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;regulation of neurogenesis#GO:0050767;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of developmental process#GO:0050793;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;regulation of nervous system development#GO:0051960;anatomical structure development#GO:0048856;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252 nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;nuclear protein-containing complex#GO:0140513 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264;basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=28598|UniProtKB=Q86XM0 Q86XM0 CATSPERD PTHR33722:SF1 CATION CHANNEL SPERM-ASSOCIATED PROTEIN SUBUNIT DELTA-RELATED CATION CHANNEL SPERM-ASSOCIATED AUXILIARY SUBUNIT DELTA spermatid differentiation#GO:0048515;cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;sexual reproduction#GO:0019953;spermatid development#GO:0007286;cilium-dependent cell motility#GO:0060285;anatomical structure development#GO:0048856;multicellular organismal reproductive process#GO:0048609;developmental process involved in reproduction#GO:0003006;anatomical structure maturation#GO:0071695;germ cell development#GO:0007281;sperm motility#GO:0097722;cell differentiation#GO:0030154;microtubule-based movement#GO:0007018;gamete generation#GO:0007276;cell motility#GO:0048870;cell development#GO:0048468;reproductive process#GO:0022414;cellular process involved in reproduction in multicellular organism#GO:0022412;flagellated sperm motility#GO:0030317;spermatogenesis#GO:0007283;developmental process#GO:0032502;cell maturation#GO:0048469;cellular developmental process#GO:0048869;microtubule-based process#GO:0007017;cilium movement involved in cell motility#GO:0060294;cellular process#GO:0009987;developmental maturation#GO:0021700;male gamete generation#GO:0048232;sperm capacitation#GO:0048240 transporter complex#GO:1990351;cation channel complex#GO:0034703;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;CatSper complex#GO:0036128;sperm flagellum#GO:0036126;monoatomic ion channel complex#GO:0034702;cell periphery#GO:0071944;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;transmembrane transporter complex#GO:1902495;cilium#GO:0005929;9+2 motile cilium#GO:0097729;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;motile cilium#GO:0031514;organelle#GO:0043226;sperm principal piece#GO:0097228;plasma membrane protein complex#GO:0098797;calcium channel complex#GO:0034704;voltage-gated calcium channel complex#GO:0005891;membrane protein complex#GO:0098796 voltage-gated ion channel#PC00241;transporter#PC00227 HUMAN|HGNC=4394|UniProtKB=P19087 P19087 GNAT2 PTHR10218:SF68 GTP-BINDING PROTEIN ALPHA SUBUNIT GUANINE NUCLEOTIDE-BINDING PROTEIN G(T) SUBUNIT ALPHA-2 pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817;molecular function regulator activity#GO:0098772;ribonucleoside triphosphate phosphatase activity#GO:0017111;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity#GO:0016787 sensory perception of chemical stimulus#GO:0007606;sensory perception of taste#GO:0050909;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;detection of chemical stimulus involved in sensory perception of bitter taste#GO:0001580;system process#GO:0003008;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;cellular process#GO:0009987;signal transduction#GO:0007165;multicellular organismal process#GO:0032501;response to chemical#GO:0042221;biological regulation#GO:0065007;detection of chemical stimulus involved in sensory perception#GO:0050907;G protein-coupled receptor signaling pathway#GO:0007186;nervous system process#GO:0050877;detection of chemical stimulus involved in sensory perception of taste#GO:0050912;sensory perception#GO:0007600;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;detection of chemical stimulus#GO:0009593;sensory perception of bitter taste#GO:0050913;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052 protein-containing complex#GO:0032991;plasma membrane#GO:0005886;cytoplasm#GO:0005737;9+0 non-motile cilium#GO:0097731;membrane#GO:0016020;neuron projection#GO:0043005;photoreceptor cell cilium#GO:0097733;cell periphery#GO:0071944;extrinsic component of membrane#GO:0019898;extrinsic component of plasma membrane#GO:0019897;cytoplasmic side of membrane#GO:0098562;photoreceptor outer segment#GO:0001750;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;membrane protein complex#GO:0098796;cytoplasmic side of plasma membrane#GO:0009898;plasma membrane protein complex#GO:0098797;side of membrane#GO:0098552;membrane-bounded organelle#GO:0043227;non-motile cilium#GO:0097730;intracellular anatomical structure#GO:0005622;photoreceptor inner segment#GO:0001917;catalytic complex#GO:1902494;cilium#GO:0005929;extrinsic component of cytoplasmic side of plasma membrane#GO:0031234 G-protein#PC00020;heterotrimeric G-protein#PC00117 Metabotropic glutamate receptor group II pathway#P00040>G-protein#P01047;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>G-Protein#P01085;PI3 kinase pathway#P00048>Galpha#P01199 HUMAN|HGNC=29098|UniProtKB=Q9Y4C8 Q9Y4C8 RBM19 PTHR23147:SF48 SERINE/ARGININE RICH SPLICING FACTOR RNA-BINDING PROTEIN 19-RELATED intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear speck#GO:0016607;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;membraneless organelle#GO:0043228;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;nuclear body#GO:0016604;intracellular membraneless organelle#GO:0043232;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080 RNA processing factor#PC00147;RNA splicing factor#PC00148;RNA metabolism protein#PC00031 HUMAN|HGNC=559|UniProtKB=P61966 P61966 AP1S1 PTHR11753:SF14 ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY AP-1 COMPLEX SUBUNIT SIGMA-1A establishment of localization#GO:0051234;vesicle-mediated transport#GO:0016192;localization#GO:0051179;transport#GO:0006810;cellular process#GO:0009987 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229 vesicle coat protein#PC00235;membrane traffic protein#PC00150 HUMAN|HGNC=10718|UniProtKB=P16581 P16581 SELE PTHR19325:SF493 COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING E-SELECTIN oligosaccharide binding#GO:0070492;carbohydrate derivative binding#GO:0097367;carbohydrate binding#GO:0030246;organic acid binding#GO:0043177;anion binding#GO:0043168;carboxylic acid binding#GO:0031406;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167 cell-cell adhesion#GO:0098609;leukocyte cell-cell adhesion#GO:0007159;cellular process#GO:0009987;heterophilic cell-cell adhesion#GO:0007157;response to stimulus#GO:0050896;response to cytokine#GO:0034097;response to chemical#GO:0042221;cell motility#GO:0048870;cell migration#GO:0016477;leukocyte migration#GO:0050900;immune system process#GO:0002376;cell adhesion#GO:0007155;response to peptide#GO:1901652 membrane#GO:0016020;cell periphery#GO:0071944;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;external side of plasma membrane#GO:0009897;extracellular region#GO:0005576;side of membrane#GO:0098552 defense/immunity protein#PC00090;complement component#PC00078 HUMAN|HGNC=18667|UniProtKB=Q10713 Q10713 PMPCA PTHR11851:SF192 METALLOPROTEASE MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA macromolecule localization#GO:0033036;protein localization to mitochondrion#GO:0070585;localization#GO:0051179;protein localization to organelle#GO:0033365;intracellular protein localization#GO:0008104 membrane-enclosed lumen#GO:0031974;protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;peptidase complex#GO:1905368;cytoplasm#GO:0005737;endopeptidase complex#GO:1905369;organelle lumen#GO:0043233;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;mitochondrial matrix#GO:0005759;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 protease#PC00190;metalloprotease#PC00153 HUMAN|HGNC=14820|UniProtKB=Q8NGX6 Q8NGX6 OR10R2 PTHR26451:SF42 G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN OLFACTORY RECEPTOR 10R2 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;binding#GO:0005488;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;response to chemical#GO:0042221;response to stimulus#GO:0050896;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;detection of chemical stimulus#GO:0009593;system process#GO:0003008;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;nervous system process#GO:0050877;sensory perception#GO:0007600 cellular anatomical structure#GO:0110165;membrane#GO:0016020 G-protein coupled receptor#PC00021 HUMAN|HGNC=8816|UniProtKB=O15530 O15530 PDPK1 PTHR24356:SF449 SERINE/THREONINE-PROTEIN KINASE 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987;response to hormone#GO:0009725;biological regulation#GO:0065007;response to peptide hormone#GO:0043434;response to chemical#GO:0042221;cellular response to nitrogen compound#GO:1901699;cell surface receptor signaling pathway#GO:0007166;cellular response to insulin stimulus#GO:0032869;regulation of biological process#GO:0050789;response to insulin#GO:0032868;cellular response to stimulus#GO:0051716;response to endogenous stimulus#GO:0009719;signaling#GO:0023052;cellular response to peptide hormone stimulus#GO:0071375;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;cellular response to hormone stimulus#GO:0032870;regulation of cellular process#GO:0050794;insulin receptor signaling pathway#GO:0008286;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;response to oxygen-containing compound#GO:1901700;cellular response to chemical stimulus#GO:0070887;response to nitrogen compound#GO:1901698;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167 non-receptor serine/threonine protein kinase#PC00167 p53 pathway#P00059>PDK1/2#P04616;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PDK1#P00831;PI3 kinase pathway#P00048>P110ACT#P01177;Ras Pathway#P04393>PDK#P04555;Interleukin signaling pathway#P00036>PDK1/2#P00985;PI3 kinase pathway#P00048>PDK1#P01196;CCKR signaling map#P06959>PDPK1#P07162;PI3 kinase pathway#P00048>PDK1 ACT#P01190;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>PDK1/2#P00903;PDGF signaling pathway#P00047>PDK1/2#P01164;p53 pathway feedback loops 2#P04398>PDK1/2#P04656 HUMAN|HGNC=26464|UniProtKB=Q8IZ41 Q8IZ41 RASEF PTHR47977:SF73 RAS-RELATED PROTEIN RAB RAS AND EF-HAND DOMAIN-CONTAINING PROTEIN carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;guanyl nucleotide binding#GO:0019001;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;GDP binding#GO:0019003;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;GTPase activity#GO:0003924;ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;hydrolase activity#GO:0016787 localization#GO:0051179;vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;transport#GO:0006810;cellular process#GO:0009987 perinuclear region of cytoplasm#GO:0048471;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 small GTPase#PC00208 HUMAN|HGNC=17770|UniProtKB=Q6GYQ0 Q6GYQ0 RALGAPA1 PTHR10063:SF3 TUBERIN RAL GTPASE-ACTIVATING PROTEIN SUBUNIT ALPHA-1 enzyme activator activity#GO:0008047;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;signaling#GO:0023052;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 G-protein modulator#PC00022;GTPase-activating protein#PC00257 HUMAN|HGNC=16818|UniProtKB=Q08623 Q08623 PUDP PTHR18901:SF43 2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2 PSEUDOURIDINE-5'-PHOSPHATASE hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787 metabolite interconversion enzyme#PC00262;phosphatase#PC00181 HUMAN|HGNC=16962|UniProtKB=Q99674 Q99674 CGREF1 PTHR23104:SF15 MULTIPLE COAGULATION FACTOR DEFICIENCY PROTEIN 2 NEURAL STEM CELL DERIVED NEURONAL SURVIVAL PROTEIN CELL GROWTH REGULATOR WITH EF HAND DOMAIN PROTEIN 1 negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;negative regulation of cell growth#GO:0030308;regulation of cellular component organization#GO:0051128;regulation of cell growth#GO:0001558;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of growth#GO:0040008;negative regulation of biological process#GO:0048519 membrane traffic protein#PC00150 HUMAN|HGNC=4475|UniProtKB=Q99678 Q99678 GPR20 PTHR24232:SF7 G-PROTEIN COUPLED RECEPTOR G PROTEIN-COUPLED RECEPTOR 20 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930 signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=25766|UniProtKB=Q49A88 Q49A88 CCDC14 PTHR22367:SF2 COILED-COIL DOMAIN-CONTAINING PROTEIN 14 COILED-COIL DOMAIN-CONTAINING PROTEIN 14 protein localization to centrosome#GO:0071539;macromolecule localization#GO:0033036;protein localization to cytoskeleton#GO:0044380;protein localization to microtubule cytoskeleton#GO:0072698;protein localization to organelle#GO:0033365;intracellular protein localization#GO:0008104;localization#GO:0051179;protein localization to microtubule organizing center#GO:1905508 cytoskeleton#GO:0005856;centrosome#GO:0005813;microtubule organizing center#GO:0005815;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;microtubule cytoskeleton#GO:0015630;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;centriolar satellite#GO:0034451 HUMAN|HGNC=32481|UniProtKB=Q8N813 Q8N813 PRR23E PTHR31813:SF17 PROLINE-RICH PROTEIN 23B PROLINE-RICH PROTEIN 23E HUMAN|HGNC=33463|UniProtKB=Q3ZCQ2 Q3ZCQ2 ANXA2R PTHR38820:SF1 ANNEXIN-2 RECEPTOR ANNEXIN-2 RECEPTOR transmembrane signal receptor#PC00197 HUMAN|HGNC=14860|UniProtKB=Q92575 Q92575 UBXN4 PTHR46424:SF1 UBX DOMAIN-CONTAINING PROTEIN 4 UBX DOMAIN-CONTAINING PROTEIN 4 cellular process#GO:0009987;response to stress#GO:0006950;proteasomal protein catabolic process#GO:0010498;response to chemical#GO:0042221;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;response to stimulus#GO:0050896;catabolic process#GO:0009056;protein catabolic process#GO:0030163;cellular response to stress#GO:0033554;response to endoplasmic reticulum stress#GO:0034976;ERAD pathway#GO:0036503;protein metabolic process#GO:0019538 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=16888|UniProtKB=Q9BPW9 Q9BPW9 DHRS9 PTHR43313:SF15 SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 9 all-trans-retinol dehydrogenase (NAD+) activity#GO:0004745;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;oxidoreductase activity#GO:0016491;alcohol dehydrogenase (NAD+) activity#GO:0004022;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;catalytic activity#GO:0003824 small molecule metabolic process#GO:0044281;carboxylic acid biosynthetic process#GO:0046394;regulation of hormone levels#GO:0010817;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;regulation of biological quality#GO:0065008;isoprenoid metabolic process#GO:0006720;isoprenoid biosynthetic process#GO:0008299;terpenoid metabolic process#GO:0006721;oxoacid metabolic process#GO:0043436;biosynthetic process#GO:0009058;biological regulation#GO:0065007;terpenoid biosynthetic process#GO:0016114;lipid biosynthetic process#GO:0008610;hormone metabolic process#GO:0042445;cellular process#GO:0009987;diterpenoid metabolic process#GO:0016101;monocarboxylic acid biosynthetic process#GO:0072330;retinoid metabolic process#GO:0001523;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;diterpenoid biosynthetic process#GO:0016102;metabolic process#GO:0008152 endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=19095|UniProtKB=Q96CN9 Q96CN9 GCC1 PTHR23157:SF25 GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1 GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=15593|UniProtKB=Q9UHA2 Q9UHA2 SS18L2 PTHR48617:SF1 FAMILY NOT NAMED SS18-LIKE PROTEIN 2 HUMAN|HGNC=16078|UniProtKB=Q9H169 Q9H169 STMN4 PTHR10104:SF6 STATHMIN STATHMIN-4 protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;binding#GO:0005488 neuron differentiation#GO:0030182;protein-containing complex organization#GO:0043933;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cellular process#GO:0009987;organelle organization#GO:0006996;neuron projection development#GO:0031175;nervous system development#GO:0007399;regulation of microtubule cytoskeleton organization#GO:0070507;cytoskeleton organization#GO:0007010;microtubule depolymerization#GO:0007019;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;neuron development#GO:0048666;cellular component disassembly#GO:0022411;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;cell development#GO:0048468;regulation of cellular component organization#GO:0051128;cell differentiation#GO:0030154;cell projection organization#GO:0030030;developmental process#GO:0032502;regulation of microtubule polymerization or depolymerization#GO:0031110;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;microtubule polymerization or depolymerization#GO:0031109;protein depolymerization#GO:0051261;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;regulation of microtubule-based process#GO:0032886;supramolecular fiber organization#GO:0097435;system development#GO:0048731;microtubule cytoskeleton organization#GO:0000226;anatomical structure development#GO:0048856;protein-containing complex disassembly#GO:0032984;regulation of cellular process#GO:0050794;regulation of cytoskeleton organization#GO:0051493 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;neuron projection#GO:0043005 non-motor microtubule binding protein#PC00166;microtubule or microtubule-binding cytoskeletal protein#PC00157 Cytoskeletal regulation by Rho GTPase#P00016>Op18/stathmin#P00513 HUMAN|HGNC=10619|UniProtKB=P78556 P78556 CCL20 PTHR12015:SF108 SMALL INDUCIBLE CYTOKINE A C-C MOTIF CHEMOKINE 20 cytokine#PC00083 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CHK#P00856 HUMAN|HGNC=14572|UniProtKB=Q9H310 Q9H310 RHBG PTHR11730:SF42 AMMONIUM TRANSPORTER AMMONIUM TRANSPORTER RH TYPE B channel activity#GO:0015267;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803 cellular process#GO:0009987;nitrogen compound transport#GO:0071705;homeostatic process#GO:0042592;chemical homeostasis#GO:0048878;transport#GO:0006810;inorganic ion homeostasis#GO:0098771;localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 primary active transporter#PC00068;transporter#PC00227 HUMAN|HGNC=28623|UniProtKB=Q96PS1 Q96PS1 FANCD2OS PTHR31036:SF0 FANCD2 OPPOSITE STRAND PROTEIN FANCD2 OPPOSITE STRAND PROTEIN regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;negative regulation of metabolic process#GO:0009892;regulation of lipid biosynthetic process#GO:0046890;regulation of steroid biosynthetic process#GO:0050810;regulation of cellular process#GO:0050794;negative regulation of cellular process#GO:0048523;regulation of lipid metabolic process#GO:0019216;regulation of biosynthetic process#GO:0009889 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=25843|UniProtKB=Q32MQ0 Q32MQ0 ZNF750 PTHR14678:SF1 PROLINE-RICH PROTEIN 35-RELATED ZINC FINGER PROTEIN 750 cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;chromatin binding#GO:0003682;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulatory region nucleic acid binding#GO:0001067;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription activator activity#GO:0001216;transcription regulator activity#GO:0140110;sequence-specific DNA binding#GO:0043565;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228 anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of RNA metabolic process#GO:0051252;animal gross anatomical part developmental process#GO:0160108;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;epidermis development#GO:0008544;positive regulation of transcription by RNA polymerase II#GO:0045944;developmental process#GO:0032502;tissue development#GO:0009888;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=18344|UniProtKB=Q9BX68 Q9BX68 HINT2 PTHR23089:SF18 HISTIDINE TRIAD HIT PROTEIN ADENOSINE 5'-MONOPHOSPHORAMIDASE HINT2 catalytic activity#GO:0003824;hydrolase activity#GO:0016787 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 nucleotide phosphatase#PC00173 HUMAN|HGNC=28109|UniProtKB=Q96BD8 Q96BD8 SKA1 PTHR28573:SF1 SPINDLE AND KINETOCHORE-ASSOCIATED PROTEIN 1 SKA COMPLEX SUBUNIT 1 cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;microtubule binding#GO:0008017;binding#GO:0005488;protein binding#GO:0005515 mitotic cell cycle#GO:0000278;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of microtubule cytoskeleton organization#GO:0070507;cell cycle#GO:0007049;regulation of biological process#GO:0050789;cell cycle process#GO:0022402;regulation of organelle organization#GO:0033043;cellular process#GO:0009987;regulation of microtubule polymerization or depolymerization#GO:0031110;regulation of microtubule-based process#GO:0032886;chromosome segregation#GO:0007059 microtubule#GO:0005874;spindle microtubule#GO:0005876;supramolecular fiber#GO:0099512;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitotic spindle#GO:0072686;chromosome#GO:0005694;kinetochore#GO:0000776;outer kinetochore#GO:0000940;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;spindle#GO:0005819;condensed chromosome#GO:0000793;chromosome, centromeric region#GO:0000775;cytoskeleton#GO:0005856;supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;condensed chromosome, centromeric region#GO:0000779 HUMAN|HGNC=6913|UniProtKB=P61244 P61244 MAX PTHR10328:SF3 PROTEIN MAX MYC-ASSOCIATED FACTOR X PROTEIN MAX DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110 regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 Oxidative stress response#P00046>Max#P01133 HUMAN|HGNC=6081|UniProtKB=P01308 P01308 INS PTHR11454:SF34 INSULIN/INSULIN GROWTH FACTOR INSULIN signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;binding#GO:0005488;signaling receptor binding#GO:0005102;hormone activity#GO:0005179;molecular function activator activity#GO:0140677;protein binding#GO:0005515 homeostatic process#GO:0042592;regulation of cellular process#GO:0050794;regulation of protein transport#GO:0051223;regulation of biological process#GO:0050789;carbohydrate homeostasis#GO:0033500;regulation of protein secretion#GO:0050708;regulation of protein localization#GO:0032880;regulation of establishment of protein localization#GO:0070201;regulation of secretion by cell#GO:1903530;regulation of secretion#GO:0051046;positive regulation of secretion#GO:0051047;biological regulation#GO:0065007;positive regulation of secretion by cell#GO:1903532;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of transport#GO:0051050;regulation of transport#GO:0051049;glucose homeostasis#GO:0042593;regulation of localization#GO:0032879;positive regulation of protein secretion#GO:0050714;chemical homeostasis#GO:0048878 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 growth factor#PC00112 Insulin/IGF pathway-protein kinase B signaling cascade#P00033>Insulin IGF#P00896;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>Insulin IGF#P00882;Gonadotropin-releasing hormone receptor pathway#P06664>Insulin#P06793 HUMAN|HGNC=23713|UniProtKB=Q96IT1 Q96IT1 ZNF496 PTHR23226:SF180 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER PROTEIN 496 cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=19024|UniProtKB=Q96A61 Q96A61 TRIM52 PTHR24103:SF685 E3 UBIQUITIN-PROTEIN LIGASE TRIM E3 UBIQUITIN-PROTEIN LIGASE TRIM52 ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 response to stress#GO:0006950;response to biotic stimulus#GO:0009607;defense response to symbiont#GO:0140546;immune response#GO:0006955;defense response to other organism#GO:0098542;response to stimulus#GO:0050896;response to other organism#GO:0051707;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;immune system process#GO:0002376;innate immune response#GO:0045087;defense response#GO:0006952;response to external stimulus#GO:0009605 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=21872|UniProtKB=Q9NUV9 Q9NUV9 GIMAP4 PTHR10903:SF182 GTPASE, IMAP FAMILY MEMBER-RELATED GTPASE IMAP FAMILY MEMBER 4 hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787 small GTPase#PC00208 HUMAN|HGNC=29162|UniProtKB=Q96BN6 Q96BN6 FAM149B1 PTHR31997:SF0 AGAP003710-PA PRIMARY CILIUM ASSEMBLY PROTEIN FAM149B1 plasma membrane bounded cell projection assembly#GO:0120031;cellular component organization or biogenesis#GO:0071840;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;organelle assembly#GO:0070925;localization#GO:0051179;cilium organization#GO:0044782;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cell projection organization#GO:0030030;protein localization to organelle#GO:0033365;protein localization to cilium#GO:0061512 HUMAN|HGNC=25687|UniProtKB=Q9BRP4 Q9BRP4 PAAF1 PTHR19879:SF7 TRANSCRIPTION INITIATION FACTOR TFIID PROTEASOMAL ATPASE-ASSOCIATED FACTOR 1 protein complex scaffold activity#GO:0140378;structural molecule activity#GO:0005198 transcription by RNA polymerase II#GO:0006366;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;transcription initiation at RNA polymerase II promoter#GO:0006367;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;DNA-templated transcription initiation#GO:0006352 SAGA complex#GO:0000124;chromatin#GO:0000785;protein-containing complex#GO:0032991;transcription factor TFIID complex#GO:0005669;intracellular membraneless organelle#GO:0043232;nuclear protein-containing complex#GO:0140513;histone acetyltransferase complex#GO:0000123;organelle lumen#GO:0043233;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;protein acetyltransferase complex#GO:0031248;intracellular organelle#GO:0043229;acetyltransferase complex#GO:1902493;RNA polymerase II transcription regulator complex#GO:0090575;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;proteasome complex#GO:0000502;RNA polymerase complex#GO:0030880;peptidase complex#GO:1905368;transferase complex#GO:1990234;endopeptidase complex#GO:1905369;membraneless organelle#GO:0043228;intracellular protein-containing complex#GO:0140535;transcription regulator complex#GO:0005667;chromosome#GO:0005694;nuclear DNA-directed RNA polymerase complex#GO:0055029;intracellular membrane-bounded organelle#GO:0043231;catalytic complex#GO:1902494;SAGA-type complex#GO:0070461;RNA polymerase II, holoenzyme#GO:0016591;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=13368|UniProtKB=Q96PG2 Q96PG2 MS4A10 PTHR23320:SF5 MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 10 cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227 HUMAN|HGNC=30005|UniProtKB=U3KPV4 U3KPV4 A3GALT2 PTHR10462:SF59 GLYCOSYLTRANSFERASE-RELATED ALPHA-1,3-GALACTOSYLTRANSFERASE 2 transferase activity#GO:0016740;catalytic activity#GO:0003824;glycosyltransferase activity#GO:0016757 carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;liposaccharide metabolic process#GO:1903509;lipid biosynthetic process#GO:0008610;glycolipid metabolic process#GO:0006664;glycosphingolipid biosynthetic process#GO:0006688;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;sphingolipid metabolic process#GO:0006665;sphingolipid biosynthetic process#GO:0030148;glycolipid biosynthetic process#GO:0009247;carbohydrate derivative biosynthetic process#GO:1901137 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982 glycosyltransferase#PC00111 HUMAN|HGNC=14281|UniProtKB=Q9HC73 Q9HC73 CRLF2 PTHR23036:SF163 CYTOKINE RECEPTOR CYTOKINE RECEPTOR-LIKE FACTOR 2 signaling receptor activity#GO:0038023;cytokine binding#GO:0019955;immune receptor activity#GO:0140375;cytokine receptor activity#GO:0004896;protein binding#GO:0005515;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488 cellular process#GO:0009987;positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;response to cytokine#GO:0034097;response to chemical#GO:0042221;biological regulation#GO:0065007;cell surface receptor signaling pathway#GO:0007166;positive regulation of cell population proliferation#GO:0008284;cellular response to stimulus#GO:0051716;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;cytokine-mediated signaling pathway#GO:0019221;regulation of cell population proliferation#GO:0042127;cell communication#GO:0007154;response to peptide#GO:1901652 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;signaling receptor complex#GO:0043235 transmembrane signal receptor#PC00197 HUMAN|HGNC=25394|UniProtKB=Q7Z3H4 Q7Z3H4 SAMD7 PTHR12247:SF89 POLYCOMB GROUP PROTEIN STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 7 protein binding#GO:0005515;chromatin binding#GO:0003682;histone binding#GO:0042393;binding#GO:0005488 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of metabolic process#GO:0009892;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519 transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;PRC1 complex#GO:0035102;intracellular protein-containing complex#GO:0140535;PcG protein complex#GO:0031519;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ubiquitin ligase complex#GO:0000151;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;nuclear ubiquitin ligase complex#GO:0000152;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=13681|UniProtKB=Q96JQ0 Q96JQ0 DCHS1 PTHR24027:SF423 CADHERIN-23 PROTOCADHERIN-16 beta-catenin binding#GO:0008013;protein binding#GO:0005515;cell adhesion molecule binding#GO:0050839;binding#GO:0005488 cell-cell adhesion#GO:0098609;cellular process#GO:0009987;cell adhesion#GO:0007155;cell migration#GO:0016477;cell motility#GO:0048870 extrinsic component of plasma membrane#GO:0019897;extrinsic component of membrane#GO:0019898;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944 cadherin#PC00057;cell adhesion molecule#PC00069 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HUMAN|HGNC=26726|UniProtKB=Q8N9K5 Q8N9K5 ZNF565 PTHR24377:SF70 IP01015P-RELATED ZINC FINGER PROTEIN 565 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=26189|UniProtKB=Q5VT66 Q5VT66 MTARC1 PTHR14237:SF25 MOLYBDOPTERIN COFACTOR SULFURASE MOSC MITOCHONDRIAL AMIDOXIME-REDUCING COMPONENT 1 oxidoreductase activity#GO:0016491;catalytic activity#GO:0003824;metal ion binding#GO:0046872;cation binding#GO:0043169;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;transition metal ion binding#GO:0046914 metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;cellular process#GO:0009987;small molecule metabolic process#GO:0044281;nitrate metabolic process#GO:0042126 HUMAN|HGNC=22316|UniProtKB=Q8NHG8 Q8NHG8 ZNRF2 PTHR46661:SF3 E3 UBIQUITIN-PROTEIN LIGASE ZNRF1-LIKE PROTEIN E3 UBIQUITIN-PROTEIN LIGASE ZNRF2 catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842 cellular process#GO:0009987;protein ubiquitination#GO:0016567;proteasomal protein catabolic process#GO:0010498;post-translational protein modification#GO:0043687;protein K48-linked ubiquitination#GO:0070936;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;modification-dependent protein catabolic process#GO:0019941;protein modification process#GO:0036211;primary metabolic process#GO:0044238;catabolic process#GO:0009056;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein modification by small protein conjugation or removal#GO:0070647;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=34072|UniProtKB=B2RNN3 B2RNN3 C1QTNF9B PTHR15427:SF41 EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER COMPLEMENT C1Q AND TUMOR NECROSIS FACTOR-RELATED PROTEIN 9B molecular function activator activity#GO:0140677;hormone activity#GO:0005179;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545 lipid oxidation#GO:0034440;lipid modification#GO:0030258;fatty acid metabolic process#GO:0006631;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;fatty acid oxidation#GO:0019395;small molecule metabolic process#GO:0044281;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 scaffold/adaptor protein#PC00226 HUMAN|HGNC=16861|UniProtKB=Q9Y6X2 Q9Y6X2 PIAS3 PTHR10782:SF10 ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN E3 SUMO-PROTEIN LIGASE PIAS3 transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;molecular function regulator activity#GO:0098772;catalytic activity, acting on a protein#GO:0140096;SUMO ligase activity#GO:0061665;SUMO transferase activity#GO:0019789;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-like protein ligase activity#GO:0061659;molecular function inhibitor activity#GO:0140678 negative regulation of signaling#GO:0023057;protein modification by small protein conjugation or removal#GO:0070647;regulation of signaling#GO:0023051;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of cell communication#GO:0010648;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of biological process#GO:0048519;protein modification by small protein conjugation#GO:0032446;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;metabolic process#GO:0008152;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;protein sumoylation#GO:0016925;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;negative regulation of signal transduction#GO:0009968;macromolecule modification#GO:0043412;regulation of DNA-templated transcription#GO:0006355;protein metabolic process#GO:0019538;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;primary metabolic process#GO:0044238;protein modification process#GO:0036211;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of receptor signaling pathway via STAT#GO:1904892;regulation of cell communication#GO:0010646;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of receptor signaling pathway via JAK-STAT#GO:0046425;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of response to stimulus#GO:0048585;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;post-translational protein modification#GO:0043687 membraneless organelle#GO:0043228;nucleus#GO:0005634;chromatin#GO:0000785;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;chromosome#GO:0005694;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234 JAK/STAT signaling pathway#P00038>PIAS#P01031;Interferon-gamma signaling pathway#P00035>PIAS#P00958 HUMAN|HGNC=693|UniProtKB=P36404 P36404 ARL2 PTHR45697:SF2 ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATED ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2 nucleotide binding#GO:0000166;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;guanyl nucleotide binding#GO:0019001;nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;anion binding#GO:0043168 protein maturation#GO:0051604;gene expression#GO:0010467;protein folding#GO:0006457;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152 microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 HUMAN|HGNC=2546|UniProtKB=P56202 P56202 CTSW PTHR12411:SF101 CYSTEINE PROTEASE FAMILY C1-RELATED CATHEPSIN W cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;cysteine-type endopeptidase activity#GO:0004197 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;catabolic process#GO:0009056;cellular process#GO:0009987;primary metabolic process#GO:0044238 extracellular region#GO:0005576;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;vacuole#GO:0005773 protein modifying enzyme#PC00260;cysteine protease#PC00081;protease#PC00190 HUMAN|HGNC=17644|UniProtKB=Q8TC59 Q8TC59 PIWIL2 PTHR22891:SF188 EUKARYOTIC TRANSLATION INITIATION FACTOR 2C PIWI-LIKE PROTEIN 2 RNA binding#GO:0003723;nuclease activity#GO:0004518;binding#GO:0005488;nucleic acid binding#GO:0003676;catalytic activity, acting on RNA#GO:0140098;RNA endonuclease activity#GO:0004521;RNA nuclease activity#GO:0004540;endonuclease activity#GO:0004519;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640 biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;male gamete generation#GO:0048232;negative regulation of macromolecule metabolic process#GO:0010605;macromolecule biosynthetic process#GO:0009059;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;regulatory ncRNA processing#GO:0070918;regulation of biosynthetic process#GO:0009889;spermatogenesis#GO:0007283;developmental process#GO:0032502;regulatory ncRNA-mediated gene silencing#GO:0031047;negative regulation of cellular process#GO:0048523;RNA biosynthetic process#GO:0032774;reproductive process#GO:0022414;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;nucleic acid metabolic process#GO:0090304;developmental process involved in reproduction#GO:0003006;primary metabolic process#GO:0044238;multicellular organismal reproductive process#GO:0048609;sexual reproduction#GO:0019953;piRNA processing#GO:0034587;RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;negative regulation of metabolic process#GO:0009892;gamete generation#GO:0007276;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;P granule#GO:0043186;membraneless organelle#GO:0043228;nucleus#GO:0005634;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;ribonucleoprotein granule#GO:0035770;organelle#GO:0043226;supramolecular complex#GO:0099080;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165 translation factor#PC00223;translation initiation factor#PC00224;translational protein#PC00263 HUMAN|HGNC=28044|UniProtKB=A8MV81 A8MV81 HIGD1C PTHR12297:SF10 HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED HIG1 DOMAIN FAMILY MEMBER 1C cellular component assembly#GO:0022607;mitochondrion organization#GO:0007005;mitochondrial respiratory chain complex assembly#GO:0033108;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933 mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 scaffold/adaptor protein#PC00226 HUMAN|HGNC=7400|UniProtKB=P80294 P80294 MT1H PTHR23299:SF4 METALLOTHIONEIN METALLOTHIONEIN-1H metal ion binding#GO:0046872;cation binding#GO:0043169;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 inorganic ion homeostasis#GO:0098771;cellular response to chemical stimulus#GO:0070887;cellular response to stimulus#GO:0051716;intracellular monoatomic ion homeostasis#GO:0006873;homeostatic process#GO:0042592;response to stimulus#GO:0050896;response to toxic substance#GO:0009636;response to metal ion#GO:0010038;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;response to cadmium ion#GO:0046686;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;cellular process#GO:0009987;detoxification of inorganic compound#GO:0061687;monoatomic ion homeostasis#GO:0050801;response to stress#GO:0006950;detoxification#GO:0098754;response to chemical#GO:0042221 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 defense/immunity protein#PC00090 HUMAN|HGNC=10991|UniProtKB=P05141 P05141 SLC25A5 PTHR45635:SF3 ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED ADP_ATP TRANSLOCASE 2 transfer/carrier protein#PC00219 HUMAN|HGNC=15447|UniProtKB=Q9Y4G6 Q9Y4G6 TLN2 PTHR19981:SF34 TALIN TALIN-2 integrin binding#GO:0005178;protein-containing complex binding#GO:0044877;protein binding#GO:0005515;cell adhesion molecule binding#GO:0050839;signaling receptor binding#GO:0005102;binding#GO:0005488 cellular component organization or biogenesis#GO:0071840;cell adhesion#GO:0007155;actin filament-based process#GO:0030029;actin cytoskeleton organization#GO:0030036;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component organization#GO:0016043;cell-cell adhesion#GO:0098609;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;focal adhesion#GO:0005925;cell-substrate junction#GO:0030055;cytoplasm#GO:0005737;membrane#GO:0016020;cell periphery#GO:0071944;cell junction#GO:0030054;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161 HUMAN|HGNC=18924|UniProtKB=Q8IUC0 Q8IUC0 KRTAP13-1 PTHR23262:SF246 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 13-1-RELATED structural protein#PC00211 HUMAN|HGNC=16991|UniProtKB=Q07065 Q07065 CKAP4 PTHR45161:SF1 CYTOSKELETON-ASSOCIATED PROTEIN 4 CYTOSKELETON-ASSOCIATED PROTEIN 4 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;rough endoplasmic reticulum#GO:0005791;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle membrane#GO:0031090;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;cytoplasm#GO:0005737;plasma membrane#GO:0005886;endomembrane system#GO:0012505;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=33115|UniProtKB=Q6ZN11 Q6ZN11 ZNF793 PTHR24377:SF647 IP01015P-RELATED ZINC FINGER PROTEIN 793 double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=29152|UniProtKB=Q7L804 Q7L804 RAB11FIP2 PTHR15746:SF20 RAB11-RELATED RAB11 FAMILY-INTERACTING PROTEIN 2 localization#GO:0051179;establishment of localization#GO:0051234;secretion#GO:0046903;exocytosis#GO:0006887;secretion by cell#GO:0032940;regulated exocytosis#GO:0045055;transport#GO:0006810;vesicle-mediated transport#GO:0016192;export from cell#GO:0140352;cellular process#GO:0009987 cell periphery#GO:0071944;vesicle#GO:0031982;membrane#GO:0016020;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;plasma membrane#GO:0005886;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227 small GTPase#PC00208 HUMAN|HGNC=15626|UniProtKB=P31995 P31995 FCGR2C PTHR11481:SF97 IMMUNOGLOBULIN FC RECEPTOR LOW AFFINITY IMMUNOGLOBULIN GAMMA FC REGION RECEPTOR II-B-RELATED transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488;signaling receptor activity#GO:0038023;protein-containing complex binding#GO:0044877;immune receptor activity#GO:0140375;molecular transducer activity#GO:0060089 signal transduction#GO:0007165;positive regulation of transport#GO:0051050;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;response to stress#GO:0006950;regulation of multicellular organismal process#GO:0051239;positive regulation of macromolecule metabolic process#GO:0010604;regulation of endocytosis#GO:0030100;immune effector process#GO:0002252;cell surface receptor signaling pathway#GO:0007166;regulation of transport#GO:0051049;regulation of localization#GO:0032879;regulation of biological process#GO:0050789;positive regulation of multicellular organismal process#GO:0051240;leukocyte mediated cytotoxicity#GO:0001909;signaling#GO:0023052;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;positive regulation of cellular component organization#GO:0051130;immune system process#GO:0002376;immunoglobulin mediated immune response#GO:0016064;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449;immune response#GO:0006955;positive regulation of cellular process#GO:0048522;regulation of cytokine production#GO:0001817;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;adaptive immune response#GO:0002250;positive regulation of endocytosis#GO:0045807;cell killing#GO:0001906;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;defense response#GO:0006952;regulation of biosynthetic process#GO:0009889;cellular response to stimulus#GO:0051716;regulation of macromolecule metabolic process#GO:0060255;positive regulation of cytokine production#GO:0001819;regulation of cellular process#GO:0050794;inflammatory response#GO:0006954;acute inflammatory response#GO:0002526;positive regulation of biosynthetic process#GO:0009891;cell communication#GO:0007154 membrane#GO:0016020;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;plasma membrane#GO:0005886 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=18084|UniProtKB=Q8NET8 Q8NET8 TRPV3 PTHR10582:SF6 TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 3 metal ion transmembrane transporter activity#GO:0046873;monoatomic cation channel activity#GO:0005261;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;calcium channel activity#GO:0005262;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;calcium ion transmembrane transporter activity#GO:0015085 import into cell#GO:0098657;cellular response to abiotic stimulus#GO:0071214;calcium ion transmembrane import into cytosol#GO:0097553;cellular response to chemical stress#GO:0062197;cellular component organization or biogenesis#GO:0071840;calcium ion transport#GO:0006816;response to chemical#GO:0042221;monoatomic cation transmembrane transport#GO:0098655;cytoskeleton organization#GO:0007010;response to stress#GO:0006950;organelle organization#GO:0006996;cellular process#GO:0009987;signal transduction#GO:0007165;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;cellular response to chemical stimulus#GO:0070887;cellular response to stress#GO:0033554;import across plasma membrane#GO:0098739;response to stimulus#GO:0050896;signaling#GO:0023052;cellular component organization#GO:0016043;response to abiotic stimulus#GO:0009628;calcium ion transmembrane transport#GO:0070588;regulation of biological process#GO:0050789;establishment of localization#GO:0051234;inorganic cation import across plasma membrane#GO:0098659;actin filament organization#GO:0007015;transport#GO:0006810;response to osmotic stress#GO:0006970;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transport#GO:0006812;localization#GO:0051179;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;supramolecular fiber organization#GO:0097435;cellular response to osmotic stress#GO:0071470;actin filament-based process#GO:0030029;actin cytoskeleton organization#GO:0030036;cellular response to environmental stimulus#GO:0104004;regulation of cellular process#GO:0050794;inorganic ion import across plasma membrane#GO:0099587;metal ion transport#GO:0030001;calcium ion import#GO:0070509;osmosensory signaling pathway#GO:0007231;cellular response to stimulus#GO:0051716 membrane-bounded organelle#GO:0043227;cilium#GO:0005929;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=814|UniProtKB=P20020 P20020 ATP2B1 PTHR24093:SF245 CATION TRANSPORTING ATPASE PLASMA MEMBRANE CALCIUM-TRANSPORTING ATPASE 1 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;P-type ion transporter activity#GO:0015662;monoatomic ion transmembrane transporter activity#GO:0015075;active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399;metal ion transmembrane transporter activity#GO:0046873;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626;calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324 cellular homeostasis#GO:0019725;intracellular calcium ion homeostasis#GO:0006874;intracellular chemical homeostasis#GO:0055082;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;inorganic ion homeostasis#GO:0098771;chemical homeostasis#GO:0048878;calcium ion homeostasis#GO:0055074;homeostatic process#GO:0042592;regulation of cytosolic calcium ion concentration#GO:0051480;monoatomic ion homeostasis#GO:0050801;intracellular monoatomic ion homeostasis#GO:0006873 cell periphery#GO:0071944;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 primary active transporter#PC00068 HUMAN|HGNC=9306|UniProtKB=Q9Y2T4 Q9Y2T4 PPP2R2C PTHR11871:SF5 PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B GAMMA ISOFORM enzyme regulator activity#GO:0030234;phosphatase regulator activity#GO:0019208;protein phosphatase regulator activity#GO:0019888;molecular function regulator activity#GO:0098772 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;protein serine/threonine phosphatase complex#GO:0008287;catalytic complex#GO:1902494 protein modifying enzyme#PC00260;protein phosphatase#PC00195 FGF signaling pathway#P00021>PP2A#P00629 HUMAN|HGNC=41984|UniProtKB=A0A0B4J1W7 A0A0B4J1W7 NPIPA9 PTHR15438:SF5 NUCLEAR PORE COMPLEX INTERACTING PROTEIN NUCLEAR PORE COMPLEX INTERACTING PROTEIN FAMILY MEMBER B3-RELATED HUMAN|HGNC=485|UniProtKB=O15123 O15123 ANGPT2 PTHR19143:SF199 FIBRINOGEN/TENASCIN/ANGIOPOEITIN ANGIOPOIETIN-2 receptor tyrosine kinase binding#GO:0030971;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;binding#GO:0005488;protein tyrosine kinase binding#GO:1990782;signaling receptor binding#GO:0005102;kinase binding#GO:0019900;protein binding#GO:0005515 circulatory system development#GO:0072359;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;blood vessel morphogenesis#GO:0048514;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;blood vessel development#GO:0001568;tube morphogenesis#GO:0035239;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;anatomical structure development#GO:0048856;angiogenesis#GO:0001525;enzyme-linked receptor protein signaling pathway#GO:0007167;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;tube development#GO:0035295;signal transduction#GO:0007165;cellular process#GO:0009987;multicellular organism development#GO:0007275;anatomical structure formation involved in morphogenesis#GO:0048646;vasculature development#GO:0001944;developmental process#GO:0032502;cell surface receptor signaling pathway#GO:0007166 cellular anatomical structure#GO:0110165;external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576 intercellular signal molecule#PC00207 Angiogenesis#P00005>Ang-2#P00246 HUMAN|HGNC=14905|UniProtKB=Q8TE23 Q8TE23 TAS1R2 PTHR24061:SF517 CALCIUM-SENSING RECEPTOR-RELATED TASTE RECEPTOR TYPE 1 MEMBER 2 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;taste receptor activity#GO:0008527;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089 system process#GO:0003008;multicellular organismal process#GO:0032501;sensory perception#GO:0007600;nervous system process#GO:0050877;sensory perception of taste#GO:0050909;sensory perception of chemical stimulus#GO:0007606 membrane#GO:0016020;cell periphery#GO:0071944;signaling receptor complex#GO:0043235;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=4137|UniProtKB=Q9H2C0 Q9H2C0 GAN PTHR24412:SF232 KELCH PROTEIN GIGAXONIN ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152 transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;Cul3-RING ubiquitin ligase complex#GO:0031463;ubiquitin ligase complex#GO:0000151;cullin-RING ubiquitin ligase complex#GO:0031461;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=15970|UniProtKB=Q9NRJ5 Q9NRJ5 PAPOLB PTHR10682:SF19 POLY A POLYMERASE POLY(A) POLYMERASE BETA nucleotidyltransferase activity#GO:0016779;transferase activity#GO:0016740;catalytic activity#GO:0003824;adenylyltransferase activity#GO:0070566;transferase activity, transferring phosphorus-containing groups#GO:0016772 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 mRNA polyadenylation factor#PC00146;RNA metabolism protein#PC00031 HUMAN|HGNC=18536|UniProtKB=Q8TDG4 Q8TDG4 HELQ PTHR47961:SF12 DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED HELICASE POLQ-LIKE nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543;helicase activity#GO:0004386;catalytic activity, acting on DNA#GO:0140097;DNA helicase activity#GO:0003678;isomerase activity#GO:0016853;ATP-dependent activity#GO:0140657;ATP-dependent activity, acting on DNA#GO:0008094 DNA recombination#GO:0006310;DNA damage response#GO:0006974;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;DNA double-strand break processing#GO:0000729;cellular process#GO:0009987;response to stress#GO:0006950;nucleobase-containing compound metabolic process#GO:0006139;cellular response to stress#GO:0033554;recombinational repair#GO:0000725;double-strand break repair via homologous recombination#GO:0000724;cellular response to stimulus#GO:0051716;double-strand break repair via single-strand annealing#GO:0045002;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;response to stimulus#GO:0050896 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 DNA metabolism protein#PC00009 HUMAN|HGNC=24356|UniProtKB=Q9P126 Q9P126 CLEC1B PTHR46490:SF2 C-TYPE LECTIN DOMAIN FAMILY 12 MEMBER A-RELATED C-TYPE LECTIN DOMAIN FAMILY 1 MEMBER B signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 anatomical structure development#GO:0048856;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;cell development#GO:0048468;signaling#GO:0023052;myeloid cell differentiation#GO:0030099;regulation of cellular process#GO:0050794;cell morphogenesis#GO:0000902;cell differentiation#GO:0030154;response to stimulus#GO:0050896;developmental process#GO:0032502;anatomical structure formation involved in morphogenesis#GO:0048646;cellular developmental process#GO:0048869;cellular process#GO:0009987;signal transduction#GO:0007165;biological regulation#GO:0065007;hemopoiesis#GO:0030097 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HUMAN|HGNC=6152|UniProtKB=P20702 P20702 ITGAX PTHR23220:SF135 INTEGRIN ALPHA INTEGRIN ALPHA-X signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 cell surface receptor signaling pathway#GO:0007166;cell adhesion#GO:0007155;cell-matrix adhesion#GO:0007160;cell-substrate adhesion#GO:0031589;cell communication#GO:0007154;cell-cell adhesion#GO:0098609;integrin-mediated signaling pathway#GO:0007229;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052 signaling receptor complex#GO:0043235;integrin complex#GO:0008305;membrane#GO:0016020;membrane protein complex#GO:0098796;protein complex involved in cell adhesion#GO:0098636;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cell surface#GO:0009986;plasma membrane#GO:0005886 cell adhesion molecule#PC00069;integrin#PC00126 Integrin signalling pathway#P00034>Integrin alpha#P00941 HUMAN|HGNC=44446|UniProtKB=D6R9N7 D6R9N7 USP17L18 PTHR24006:SF651 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE INACTIVE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 17-LIKE PROTEIN 4-RELATED deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;cysteine-type deubiquitinase activity#GO:0004843;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233 regulation of programmed cell death#GO:0043067;regulation of protein stability#GO:0031647;regulation of biological process#GO:0050789;regulation of apoptotic process#GO:0042981;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of biological quality#GO:0065008 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;cytosol#GO:0005829;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 protease#PC00190;cysteine protease#PC00081 HUMAN|HGNC=28778|UniProtKB=Q5GH77 Q5GH77 XKR3 PTHR14297:SF9 MEMBRANE TRANSPORT PROTEIN XK FAMILY MEMBER XK-RELATED PROTEIN 3 HUMAN|HGNC=29005|UniProtKB=O15016 O15016 TRIM66 PTHR45915:SF7 TRANSCRIPTION INTERMEDIARY FACTOR TRIPARTITE MOTIF-CONTAINING PROTEIN 66 aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transcription coregulator activity#GO:0003712;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;transcription regulator activity#GO:0140110;acyltransferase activity#GO:0016746 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of metabolic process#GO:0009892;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519 membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;chromatin#GO:0000785;nucleus#GO:0005634 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=26495|UniProtKB=Q96DN0 Q96DN0 ERP27 PTHR18929:SF193 PROTEIN DISULFIDE ISOMERASE ENDOPLASMIC RETICULUM RESIDENT PROTEIN 27 protein disulfide isomerase activity#GO:0003756;catalytic activity#GO:0003824;isomerase activity#GO:0016853;catalytic activity, acting on a protein#GO:0140096;intramolecular oxidoreductase activity#GO:0016860 primary metabolic process#GO:0044238;response to stress#GO:0006950;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;macromolecule biosynthetic process#GO:0009059;response to stimulus#GO:0050896;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;protein folding#GO:0006457;metabolic process#GO:0008152;response to endoplasmic reticulum stress#GO:0034976;cellular response to stress#GO:0033554;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 chaperone#PC00072 HUMAN|HGNC=25888|UniProtKB=Q53GT1 Q53GT1 KLHL22 PTHR45632:SF5 LD33804P KELCH-LIKE PROTEIN 22 ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238 transferase complex#GO:1990234;catalytic complex#GO:1902494;Cul3-RING ubiquitin ligase complex#GO:0031463;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535 scaffold/adaptor protein#PC00226 HUMAN|HGNC=15972|UniProtKB=Q9P253 Q9P253 VPS18 PTHR23323:SF29 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 18 HOMOLOG molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 intracellular transport#GO:0046907;transport#GO:0006810;lytic vacuole organization#GO:0080171;vacuolar transport#GO:0007034;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;endosome organization#GO:0007032;vesicle organization#GO:0016050;organelle organization#GO:0006996;lysosome organization#GO:0007040;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;organelle fusion#GO:0048284;endomembrane system organization#GO:0010256;endosome to lysosome transport#GO:0008333;lysosomal transport#GO:0007041;cellular localization#GO:0051641;localization#GO:0051179;vacuole organization#GO:0007033;cellular component organization#GO:0016043 vesicle#GO:0031982;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;cytoplasm#GO:0005737;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;vesicle tethering complex#GO:0099023 membrane traffic protein#PC00150;membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=8148|UniProtKB=O60890 O60890 OPHN1 PTHR12552:SF2 OLIGOPHRENIN 1 OLIGOPHRENIN-1 enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme activator activity#GO:0008047 biological regulation#GO:0065007;synaptic vesicle recycling#GO:0036465;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of catabolic process#GO:0009894;establishment of localization#GO:0051234;synaptic vesicle cycle#GO:0099504;transport#GO:0006810;negative regulation of cellular process#GO:0048523;modulation of chemical synaptic transmission#GO:0050804;negative regulation of proteasomal protein catabolic process#GO:1901799;regulation of cell communication#GO:0010646;negative regulation of protein metabolic process#GO:0051248;regulation of macromolecule metabolic process#GO:0060255;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;synaptic vesicle endocytosis#GO:0048488;negative regulation of catabolic process#GO:0009895;regulation of protein catabolic process#GO:0042176;localization#GO:0051179;regulation of synaptic transmission, glutamatergic#GO:0051966;actin filament-based process#GO:0030029;cytoskeleton organization#GO:0007010;regulation of proteasomal protein catabolic process#GO:0061136;negative regulation of protein catabolic process#GO:0042177;regulation of trans-synaptic signaling#GO:0099177;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle organization#GO:0006996;regulation of protein metabolic process#GO:0051246;regulation of localization#GO:0032879;regulation of transport#GO:0051049;cellular component organization or biogenesis#GO:0071840;import into cell#GO:0098657;vesicle-mediated transport in synapse#GO:0099003;regulation of endocytosis#GO:0030100;negative regulation of metabolic process#GO:0009892;regulation of cellular component organization#GO:0051128;endocytosis#GO:0006897;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;cellular localization#GO:0051641;regulation of signaling#GO:0023051 somatodendritic compartment#GO:0036477;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;presynapse#GO:0098793;neuron projection#GO:0043005;cell junction#GO:0030054;membraneless organelle#GO:0043228;axon terminus#GO:0043679;cytoskeleton#GO:0005856;organelle#GO:0043226;cellular anatomical structure#GO:0110165;synapse#GO:0045202;neuron projection terminus#GO:0044306;cell projection#GO:0042995;neuron spine#GO:0044309;distal axon#GO:0150034;terminal bouton#GO:0043195;plasma membrane bounded cell projection#GO:0120025;actin cytoskeleton#GO:0015629;postsynapse#GO:0098794;dendritic spine#GO:0043197;intracellular anatomical structure#GO:0005622;dendrite#GO:0030425;intracellular organelle#GO:0043229;dendritic tree#GO:0097447;axon#GO:0030424 GTPase-activating protein#PC00257 PDGF signaling pathway#P00047>Rho#P01174 HUMAN|HGNC=33998|UniProtKB=F5H284 F5H284 PPIAL4D PTHR11071:SF466 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A-LIKE 4C-RELATED intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HUMAN|HGNC=23479|UniProtKB=Q96BY6 Q96BY6 DOCK10 PTHR23317:SF71 DEDICATOR OF CYTOKINESIS DOCK DEDICATOR OF CYTOKINESIS PROTEIN 10 molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;guanyl-nucleotide exchange factor activity#GO:0005085 dendritic spine development#GO:0060996;dendrite morphogenesis#GO:0048813;regulation of cell communication#GO:0010646;postsynapse organization#GO:0099173;cell junction organization#GO:0034330;dendritic spine morphogenesis#GO:0060997;regulation of cellular process#GO:0050794;synapse organization#GO:0050808;system development#GO:0048731;anatomical structure development#GO:0048856;regulation of cell motility#GO:2000145;plasma membrane bounded cell projection organization#GO:0120036;regulation of locomotion#GO:0040012;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;neuron projection morphogenesis#GO:0048812;regulation of response to stimulus#GO:0048583;regulation of cell migration#GO:0030334;developmental process#GO:0032502;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;cell development#GO:0048468;regulation of Rho protein signal transduction#GO:0035023;cell morphogenesis#GO:0000902;cell differentiation#GO:0030154;cell projection organization#GO:0030030;neuron projection organization#GO:0106027;regulation of signaling#GO:0023051;generation of neurons#GO:0048699;regulation of intracellular signal transduction#GO:1902531;animal gross anatomical part developmental process#GO:0160108;neuron development#GO:0048666;dendrite development#GO:0016358;cellular process#GO:0009987;dendritic spine organization#GO:0097061;neuron projection development#GO:0031175;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;regulation of small GTPase mediated signal transduction#GO:0051056;cell projection morphogenesis#GO:0048858;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275 guanyl-nucleotide exchange factor#PC00113;protein-binding activity modulator#PC00095;G-protein modulator#PC00022 HUMAN|HGNC=11699|UniProtKB=Q13530 Q13530 SERINC3 PTHR10383:SF51 SERINE INCORPORATOR SERINE INCORPORATOR 3 membrane#GO:0016020;cellular anatomical structure#GO:0110165 protein-binding activity modulator#PC00095 HUMAN|HGNC=28791|UniProtKB=Q8N660 Q8N660 NBPF15 PTHR14199:SF35 NEUROBLASTOMA BREAKPOINT FAMILY MEMBER 6-LIKE PROTEIN NBPF FAMILY MEMBER NBPF1-RELATED HUMAN|HGNC=11692|UniProtKB=P57738 P57738 TCTA PTHR32267:SF2 T-CELL LEUKEMIA TRANSLOCATION-ALTERED GENE PROTEIN T-CELL LEUKEMIA TRANSLOCATION-ALTERED GENE PROTEIN HUMAN|HGNC=5381|UniProtKB=P14735 P14735 IDE PTHR43690:SF36 NARDILYSIN INSULIN-DEGRADING ENZYME hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metalloendopeptidase activity#GO:0004222;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237 macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;proteolysis#GO:0006508;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;regulation of biological quality#GO:0065008;peptide metabolic process#GO:0006518;primary metabolic process#GO:0044238;cellular process#GO:0009987;regulation of hormone levels#GO:0010817;peptide catabolic process#GO:0043171;catabolic process#GO:0009056;hormone metabolic process#GO:0042445;biological regulation#GO:0065007 cytosol#GO:0005829;peroxisome#GO:0005777;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;mitochondrion#GO:0005739;microbody#GO:0042579;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;peroxisomal matrix#GO:0005782 protease#PC00190;metalloprotease#PC00153;protein modifying enzyme#PC00260 HUMAN|HGNC=48628|UniProtKB=A0A1B0GTD5 A0A1B0GTD5 SPMIP11 PTHR35263:SF1 TESTIS-EXPRESSED PROTEIN 49 SPERM MICROTUBULE INNER PROTEIN 11 cytoplasmic microtubule#GO:0005881;organelle#GO:0043226;cellular anatomical structure#GO:0110165;axonemal microtubule#GO:0005879;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cilium#GO:0005929;intracellular organelle#GO:0043229;microtubule#GO:0005874;axoneme#GO:0005930;membrane-bounded organelle#GO:0043227;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;microtubule cytoskeleton#GO:0015630;A axonemal microtubule#GO:0097649;axonemal doublet microtubule#GO:0097545;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;ciliary plasm#GO:0097014;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;cytoskeleton#GO:0005856;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228 HUMAN|HGNC=32363|UniProtKB=Q8WUX2 Q8WUX2 CHAC2 PTHR12192:SF2 CATION TRANSPORT PROTEIN CHAC-RELATED GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOTRANSFERASE 2 HUMAN|HGNC=8812|UniProtKB=Q16654 Q16654 PDK4 PTHR11947:SF22 PYRUVATE DEHYDROGENASE KINASE [PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE ISOZYME 4, MITOCHONDRIAL catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 response to oxygen-containing compound#GO:1901700;insulin receptor signaling pathway#GO:0008286;cellular response to chemical stimulus#GO:0070887;signaling#GO:0023052;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;cellular response to hormone stimulus#GO:0032870;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;cell surface receptor signaling pathway#GO:0007166;response to chemical#GO:0042221;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987;response to hormone#GO:0009725;response to nitrogen compound#GO:1901698;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;regulation of lipid metabolic process#GO:0019216;cellular response to peptide hormone stimulus#GO:0071375;regulation of cellular process#GO:0050794;response to insulin#GO:0032868;cellular response to stimulus#GO:0051716;regulation of biosynthetic process#GO:0009889;cellular response to insulin stimulus#GO:0032869;regulation of carbohydrate metabolic process#GO:0006109;biological regulation#GO:0065007;response to peptide hormone#GO:0043434;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular response to nitrogen compound#GO:1901699;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=8028|UniProtKB=P78549 P78549 NTHL1 PTHR43286:SF7 ENDONUCLEASE III-LIKE PROTEIN 1 ENDONUCLEASE III-LIKE PROTEIN 1 hydrolase activity#GO:0016787;DNA endonuclease activity#GO:0004520;nuclease activity#GO:0004518;DNA N-glycosylase activity#GO:0019104;catalytic activity, acting on DNA#GO:0140097;hydrolase activity, acting on glycosyl bonds#GO:0016798;endonuclease activity#GO:0004519;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;DNA nuclease activity#GO:0004536 nucleobase-containing compound metabolic process#GO:0006139;nucleotide-excision repair#GO:0006289;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;response to stress#GO:0006950;nucleic acid metabolic process#GO:0090304;base-excision repair#GO:0006284;macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;cellular response to stress#GO:0033554;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA metabolism protein#PC00009;DNA glycosylase#PC00010 HUMAN|HGNC=25807|UniProtKB=Q96CW6 Q96CW6 SLC7A6OS PTHR31196:SF2 RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED HUMAN|HGNC=16171|UniProtKB=Q9H444 Q9H444 CHMP4B PTHR22761:SF4 CHARGED MULTIVESICULAR BODY PROTEIN CHARGED MULTIVESICULAR BODY PROTEIN 4B intracellular transport#GO:0046907;transport#GO:0006810;vacuolar transport#GO:0007034;establishment of localization#GO:0051234;nucleus organization#GO:0006997;cellular component organization or biogenesis#GO:0071840;vesicle budding from membrane#GO:0006900;vesicle organization#GO:0016050;nuclear envelope organization#GO:0006998;endosomal transport#GO:0016197;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;nuclear membrane organization#GO:0071763;multivesicular body sorting pathway#GO:0071985;late endosome to vacuole transport via multivesicular body sorting pathway#GO:0032511;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;cellular component assembly#GO:0022607;endosome transport via multivesicular body sorting pathway#GO:0032509;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;cellular localization#GO:0051641;localization#GO:0051179;cellular component organization#GO:0016043;membrane assembly#GO:0071709;late endosome to vacuole transport#GO:0045324 intracellular organelle#GO:0043229;endosome#GO:0005768;endosome membrane#GO:0010008;side of membrane#GO:0098552;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;organelle envelope#GO:0031967;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;cytoplasmic side of plasma membrane#GO:0009898;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasmic side of membrane#GO:0098562;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;vesicle membrane#GO:0012506;membrane#GO:0016020;nucleus#GO:0005634;cell periphery#GO:0071944;late endosome#GO:0005770;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;plasma membrane#GO:0005886;nuclear envelope#GO:0005635;cytoplasm#GO:0005737 membrane traffic protein#PC00150 HUMAN|HGNC=12582|UniProtKB=P14927 P14927 UQCRB PTHR12022:SF12 UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 14 KD PROTEIN CYTOCHROME B-C1 COMPLEX SUBUNIT 7 mitochondrial ATP synthesis coupled electron transport#GO:0042775;mitochondrial electron transport, ubiquinol to cytochrome c#GO:0006122;respiratory electron transport chain#GO:0022904;cellular process#GO:0009987;electron transport chain#GO:0022900;generation of precursor metabolites and energy#GO:0006091;metabolic process#GO:0008152;aerobic electron transport chain#GO:0019646;aerobic respiration#GO:0009060;ATP synthesis coupled electron transport#GO:0042773;oxidative phosphorylation#GO:0006119;cellular respiration#GO:0045333;energy derivation by oxidation of organic compounds#GO:0015980 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytochrome complex#GO:0070069;respiratory chain complex#GO:0098803;oxidoreductase complex#GO:1990204;membrane#GO:0016020;membrane protein complex#GO:0098796;respiratory chain complex III#GO:0045275;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;catalytic complex#GO:1902494 reductase#PC00198;oxidoreductase#PC00176 HUMAN|HGNC=16898|UniProtKB=O43281 O43281 EFS PTHR10654:SF14 CAS SCAFFOLDING PROTEIN EMBRYONAL FYN-ASSOCIATED SUBSTRATE cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell motility#GO:0048870;cell migration#GO:0016477;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cell surface receptor signaling pathway#GO:0007166;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154 anchoring junction#GO:0070161;intracellular anatomical structure#GO:0005622;cell junction#GO:0030054;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cell-substrate junction#GO:0030055;focal adhesion#GO:0005925;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=53855|UniProtKB=A0A1W2PPW3 A0A1W2PPW3 TAF11L12 PTHR13218:SF15 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11-RELATED TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 11 LIKE PROTEIN 2-RELATED RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;RNA polymerase II preinitiation complex assembly#GO:0051123;DNA-templated transcription initiation#GO:0006352;protein-containing complex assembly#GO:0065003;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-DNA complex organization#GO:0071824;transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;protein-DNA complex assembly#GO:0065004;cellular component assembly#GO:0022607;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;transcription initiation at RNA polymerase II promoter#GO:0006367;cellular component biogenesis#GO:0044085 transferase complex#GO:1990234;transcription regulator complex#GO:0005667;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;RNA polymerase II transcription regulator complex#GO:0090575;transcription factor TFIID complex#GO:0005669;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;RNA polymerase II, holoenzyme#GO:0016591;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165 general transcription factor#PC00259;RNA metabolism protein#PC00031 Transcription regulation by bZIP transcription factor#P00055>TBP-associated factors#P01385;General transcription regulation#P00023>TBP-associated factors#P00658 HUMAN|HGNC=10931|UniProtKB=O00476 O00476 SLC17A3 PTHR11662:SF134 SOLUTE CARRIER FAMILY 17 SODIUM-DEPENDENT PHOSPHATE TRANSPORT PROTEIN 4 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic anion transmembrane transporter activity#GO:0008509;passive transmembrane transporter activity#GO:0022803;efflux transmembrane transporter activity#GO:0015562;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;voltage-gated monoatomic anion channel activity#GO:0008308;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;channel activity#GO:0015267;voltage-gated channel activity#GO:0022832;monoatomic anion channel activity#GO:0005253;xenobiotic transmembrane transporter activity#GO:0042910 establishment of localization#GO:0051234;localization#GO:0051179;nitrogen compound transport#GO:0071705;transport#GO:0006810 cell periphery#GO:0071944;apical part of cell#GO:0045177;membrane#GO:0016020;apical plasma membrane#GO:0016324;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590 secondary carrier transporter#PC00258 HUMAN|HGNC=16942|UniProtKB=Q76MJ5 Q76MJ5 ERN2 PTHR13954:SF15 IRE1-RELATED SERINE_THREONINE-PROTEIN KINASE_ENDORIBONUCLEASE IRE2 protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;nuclease activity#GO:0004518;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;RNA endonuclease activity#GO:0004521;catalytic activity, acting on RNA#GO:0140098;RNA nuclease activity#GO:0004540;endonuclease activity#GO:0004519 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress#GO:0070059;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;response to topologically incorrect protein#GO:0035966;programmed cell death#GO:0012501;cell death#GO:0008219;apoptotic process#GO:0006915;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;intrinsic apoptotic signaling pathway#GO:0097193;cell communication#GO:0007154;response to unfolded protein#GO:0006986;intracellular signal transduction#GO:0035556;response to endoplasmic reticulum stress#GO:0034976;cellular response to unfolded protein#GO:0034620;cellular response to topologically incorrect protein#GO:0035967;cellular response to stress#GO:0033554;biological regulation#GO:0065007;response to stress#GO:0006950;endoplasmic reticulum unfolded protein response#GO:0030968;cellular process#GO:0009987;signal transduction#GO:0007165;apoptotic signaling pathway#GO:0097190 membrane protein complex#GO:0098796;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasm#GO:0005737;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endoplasmic reticulum protein-containing complex#GO:0140534;organelle membrane#GO:0031090 transmembrane signal receptor#PC00197;tyrosine protein kinase receptor#PC00233 Alzheimer disease-presenilin pathway#P00004>Ire-1#P00144;Alzheimer disease-presenilin pathway#P00004>Ire-1 C-terminal fragment#P00125;Alzheimer disease-presenilin pathway#P00004>Ire-1 N-terminal fragment#P00110 HUMAN|HGNC=18416|UniProtKB=Q9BVA6 Q9BVA6 FICD PTHR13504:SF34 FIDO DOMAIN-CONTAINING PROTEIN DDB_G0283145 PROTEIN ADENYLYLTRANSFERASE FICD catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;phosphoric diester hydrolase activity#GO:0008081;hydrolase activity#GO:0016787 macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;protein modification process#GO:0036211;primary metabolic process#GO:0044238;metabolic process#GO:0008152 HUMAN|HGNC=3447|UniProtKB=P84090 P84090 ERH PTHR12373:SF9 ENHANCER OF RUDIMENTARY ERH ENHANCER OF RUDIMENTARY HOMOLOG molecular function inhibitor activity#GO:0140678;molecular function regulator activity#GO:0098772 cellular process#GO:0009987;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;RNA processing#GO:0006396;gene expression#GO:0010467;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;nucleobase-containing compound biosynthetic process#GO:0034654;RNA 3'-end processing#GO:0031123;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;regulation of cellular component organization#GO:0051128;RNA catabolic process#GO:0006401;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;negative regulation of macromolecule metabolic process#GO:0010605;nucleic acid catabolic process#GO:0141188;macromolecule biosynthetic process#GO:0009059;nucleobase-containing compound catabolic process#GO:0034655;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;nuclear mRNA surveillance#GO:0071028;regulatory ncRNA-mediated gene silencing#GO:0031047;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulatory ncRNA processing#GO:0070918;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of chromatin organization#GO:1902275 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 DNA-binding transcription factor#PC00218 HUMAN|HGNC=1462|UniProtKB=Q13557 Q13557 CAMK2D PTHR24347:SF365 SERINE/THREONINE-PROTEIN KINASE CALCIUM_CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT DELTA catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;calmodulin binding#GO:0005516;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein kinase activity#GO:0004672;protein binding#GO:0005515;phosphotransferase activity, alcohol group as acceptor#GO:0016773;calcium/calmodulin-dependent protein kinase activity#GO:0004683;protein serine/threonine kinase activity#GO:0004674;binding#GO:0005488 regulation of synaptic plasticity#GO:0048167;regulation of signaling#GO:0023051;regulation of neuronal synaptic plasticity#GO:0048168;regulation of biological quality#GO:0065008;regulation of protein localization#GO:0032880;regulation of localization#GO:0032879;regulation of biological process#GO:0050789;regulation of protein localization to membrane#GO:1905475;regulation of cellular process#GO:0050794;regulation of trans-synaptic signaling#GO:0099177;regulation of cell communication#GO:0010646;biological regulation#GO:0065007;modulation of chemical synaptic transmission#GO:0050804 cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737;asymmetric synapse#GO:0032279;postsynaptic specialization#GO:0099572;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;neuron to neuron synapse#GO:0098984;neuron projection#GO:0043005;postsynapse#GO:0098794;intracellular anatomical structure#GO:0005622;cell junction#GO:0030054;axon#GO:0030424;postsynaptic density#GO:0014069 non-receptor serine/threonine protein kinase#PC00167 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CaMK#P00847;Ionotropic glutamate receptor pathway#P00037>CaMKII#P01023 HUMAN|HGNC=227|UniProtKB=Q9NS39 Q9NS39 ADARB2 PTHR10910:SF17 EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN INACTIVE DOUBLE-STRANDED RNA-SPECIFIC EDITASE B2 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814;catalytic activity, acting on RNA#GO:0140098;deaminase activity#GO:0019239;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;adenosine deaminase activity#GO:0004000;catalytic activity, acting on a tRNA#GO:0140101;hydrolase activity#GO:0016787;RNA binding#GO:0003723;double-stranded RNA binding#GO:0003725;tRNA-specific adenosine deaminase activity#GO:0008251;nucleic acid binding#GO:0003676;binding#GO:0005488 nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;gene expression#GO:0010467;RNA modification#GO:0009451;nucleic acid biosynthetic process#GO:0141187;base conversion or substitution editing#GO:0016553;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;adenosine to inosine editing#GO:0006382;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233 RNA metabolism protein#PC00031 HUMAN|HGNC=3167|UniProtKB=Q99500 Q99500 S1PR3 PTHR22750:SF24 G-PROTEIN COUPLED RECEPTOR SPHINGOSINE 1-PHOSPHATE RECEPTOR 3 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HUMAN|HGNC=13939|UniProtKB=Q9Y334 Q9Y334 VWA7 PTHR14905:SF7 NG37 VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 7 HUMAN|HGNC=21166|UniProtKB=Q8TAI7 Q8TAI7 RHEBL1 PTHR24070:SF253 RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY GTPASE RHEBL1 GTPase activity#GO:0003924;kinase activator activity#GO:0019209;hydrolase activity#GO:0016787;protein kinase activator activity#GO:0030295;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;molecular function regulator activity#GO:0098772;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;hydrolase activity, acting on acid anhydrides#GO:0016817;protein serine/threonine kinase activator activity#GO:0043539;enzyme activator activity#GO:0008047;protein kinase regulator activity#GO:0019887;kinase regulator activity#GO:0019207 signaling#GO:0023052;regulation of cell communication#GO:0010646;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;positive regulation of TOR signaling#GO:0032008;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;intracellular signaling cassette#GO:0141124;positive regulation of response to stimulus#GO:0048584;positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;regulation of TOR signaling#GO:0032006;cellular process#GO:0009987;positive regulation of TORC1 signaling#GO:1904263;regulation of TORC1 signaling#GO:1903432;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 small GTPase#PC00208 HUMAN|HGNC=19441|UniProtKB=Q8IUF8 Q8IUF8 RIOX2 PTHR13096:SF7 MINA53 MYC INDUCED NUCLEAR ANTIGEN RIBOSOMAL OXYGENASE 2 HUMAN|HGNC=8323|UniProtKB=Q96R09 Q96R09 OR5B2 PTHR48018:SF116 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5B2 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 regulation of cellular process#GO:0050794;sensory perception of smell#GO:0007608;response to stimulus#GO:0050896;signaling#GO:0023052;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;nervous system process#GO:0050877;sensory perception#GO:0007600;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=29574|UniProtKB=Q86XK3 Q86XK3 SFR1 PTHR28643:SF1 SWI5-DEPENDENT RECOMBINATION DNA REPAIR PROTEIN 1 HOMOLOG SWI5-DEPENDENT RECOMBINATION DNA REPAIR PROTEIN 1 HOMOLOG transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription coactivator activity#GO:0003713 positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;double-strand break repair via homologous recombination#GO:0000724;regulation of biological process#GO:0050789;double-strand break repair#GO:0006302;DNA recombination#GO:0006310;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;response to stress#GO:0006950;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;recombinational repair#GO:0000725;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;cellular response to stimulus#GO:0051716;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;DNA repair#GO:0006281;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090 nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;chromatin#GO:0000785;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165 DNA metabolism protein#PC00009 HUMAN|HGNC=16628|UniProtKB=Q96SL1 Q96SL1 SLC49A4 PTHR10924:SF27 MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED SOLUTE CARRIER FAMILY 49 MEMBER 4 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane#GO:0016020 secondary carrier transporter#PC00258 HUMAN|HGNC=25378|UniProtKB=Q8N612 Q8N612 FHIP1B PTHR21705:SF4 RAI16 PROTEIN-RELATED FHF COMPLEX SUBUNIT HOOK-INTERACTING PROTEIN 1B cellular component organization#GO:0016043;endosome to lysosome transport#GO:0008333;lysosomal transport#GO:0007041;cellular localization#GO:0051641;localization#GO:0051179;vacuole organization#GO:0007033;organelle organization#GO:0006996;early endosome to late endosome transport#GO:0045022;lysosome organization#GO:0007040;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;endomembrane system organization#GO:0010256;intracellular transport#GO:0046907;transport#GO:0006810;lytic vacuole organization#GO:0080171;vacuolar transport#GO:0007034;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;vesicle organization#GO:0016050;endosome organization#GO:0007032;endosomal transport#GO:0016197 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 HUMAN|HGNC=24942|UniProtKB=Q96FE7 Q96FE7 PIK3IP1 PTHR24261:SF16 PLASMINOGEN-RELATED PHOSPHOINOSITIDE-3-KINASE-INTERACTING PROTEIN 1 catalytic activity#GO:0003824;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity, acting on a protein#GO:0140096;signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515;hydrolase activity#GO:0016787 biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of signal transduction#GO:0009968;negative regulation of response to stimulus#GO:0048585;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051896;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 serine protease#PC00203;protein modifying enzyme#PC00260 HUMAN|HGNC=9451|UniProtKB=P04070 P04070 PROC PTHR24278:SF0 COAGULATION FACTOR VITAMIN K-DEPENDENT PROTEIN C endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;catalytic activity#GO:0003824;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;serine-type peptidase activity#GO:0008236 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 serine protease#PC00203 Blood coagulation#P00011>PC#P00426;Blood coagulation#P00011>APC#P00423 HUMAN|HGNC=17128|UniProtKB=Q9BRY0 Q9BRY0 SLC39A3 PTHR11040:SF221 ZINC/IRON TRANSPORTER ZINC TRANSPORTER ZIP3 metal ion transmembrane transporter activity#GO:0046873;monoatomic cation transmembrane transporter activity#GO:0008324;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;zinc ion transmembrane transporter activity#GO:0005385;transition metal ion transmembrane transporter activity#GO:0046915 cellular process#GO:0009987;zinc ion transport#GO:0006829;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;transport#GO:0006810;inorganic cation import across plasma membrane#GO:0098659;import into cell#GO:0098657;establishment of localization#GO:0051234;inorganic ion import across plasma membrane#GO:0099587;metal ion transport#GO:0030001;import across plasma membrane#GO:0098739;transition metal ion transport#GO:0000041;zinc ion transmembrane transport#GO:0071577;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 secondary carrier transporter#PC00258 HUMAN|HGNC=34520|UniProtKB=Q6ZS10 Q6ZS10 CLEC17A PTHR22802:SF445 C-TYPE LECTIN SUPERFAMILY MEMBER C-TYPE LECTIN DOMAIN FAMILY 17, MEMBER A signaling receptor activity#GO:0038023;carbohydrate binding#GO:0030246;pattern recognition receptor activity#GO:0038187;molecular transducer activity#GO:0060089;binding#GO:0005488 response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020;plasma membrane#GO:0005886;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;cell surface#GO:0009986 membrane traffic protein#PC00150 HUMAN|HGNC=6017|UniProtKB=Q01344 Q01344 IL5RA PTHR23036:SF17 CYTOKINE RECEPTOR INTERLEUKIN-5 RECEPTOR SUBUNIT ALPHA immune receptor activity#GO:0140375;cytokine binding#GO:0019955;signaling receptor activity#GO:0038023;cytokine receptor activity#GO:0004896;protein binding#GO:0005515;molecular transducer activity#GO:0060089;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888 response to cytokine#GO:0034097;response to chemical#GO:0042221;biological regulation#GO:0065007;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;cell surface receptor signaling pathway#GO:0007166;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;positive regulation of cell population proliferation#GO:0008284;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;response to peptide#GO:1901652;cytokine-mediated signaling pathway#GO:0019221 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;signaling receptor complex#GO:0043235;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 Interleukin signaling pathway#P00036>Receptor subunit alpha#P00992 HUMAN|HGNC=16396|UniProtKB=Q9BZF1 Q9BZF1 OSBPL8 PTHR10972:SF216 OXYSTEROL-BINDING PROTEIN-RELATED OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 8 sterol binding#GO:0032934;binding#GO:0005488;small molecule binding#GO:0036094;steroid binding#GO:0005496;lipid binding#GO:0008289;cholesterol binding#GO:0015485;alcohol binding#GO:0043178 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829;membrane#GO:0016020 transfer/carrier protein#PC00219 HUMAN|HGNC=21016|UniProtKB=Q5TDP6 Q5TDP6 LGSN PTHR43407:SF1 GLUTAMINE SYNTHETASE LENGSIN ligase activity, forming carbon-nitrogen bonds#GO:0016879;catalytic activity#GO:0003824;ligase activity#GO:0016874 small molecule metabolic process#GO:0044281;response to stimulus#GO:0050896;homeostatic process#GO:0042592;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;carboxylic acid biosynthetic process#GO:0046394;oxoacid metabolic process#GO:0043436;proteinogenic amino acid metabolic process#GO:0170039;biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;response to nutrient levels#GO:0031667;cellular process#GO:0009987;proteinogenic amino acid biosynthetic process#GO:0170038;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;metabolic process#GO:0008152;amino acid biosynthetic process#GO:0008652;small molecule biosynthetic process#GO:0044283;chemical homeostasis#GO:0048878 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;membrane#GO:0016020 ligase#PC00142 Glutamine glutamate conversion#P02745>Glutamine synthase#P04483 HUMAN|HGNC=28309|UniProtKB=Q6PL45 Q6PL45 BRICD5 PTHR16483:SF0 GASTROKINE 1 BRICHOS DOMAIN-CONTAINING PROTEIN 5 regulation of biological process#GO:0050789;regulation of cell population proliferation#GO:0042127;regulation of cellular process#GO:0050794;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=13861|UniProtKB=Q9Y250 Q9Y250 LZTS1 PTHR19354:SF5 ZIPPER PUTATIVE TUMOR SUPPRESSOR 2 HOMOLOG-LIKE PROTEIN-RELATED ZIPPER PUTATIVE TUMOR SUPPRESSOR 1-RELATED regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of anatomical structure morphogenesis#GO:0022603;regulation of synaptic plasticity#GO:0048167;regulation of cell projection organization#GO:0031344;regulation of trans-synaptic signaling#GO:0099177;biological regulation#GO:0065007;regulation of neuron projection development#GO:0010975;regulation of biological quality#GO:0065008;regulation of signaling#GO:0023051;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of dendrite development#GO:0050773;regulation of developmental process#GO:0050793;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;regulation of dendrite morphogenesis#GO:0048814;regulation of biological process#GO:0050789 neuron spine#GO:0044309;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;somatodendritic compartment#GO:0036477;cellular anatomical structure#GO:0110165;synapse#GO:0045202;dendritic spine#GO:0043197;neuron projection#GO:0043005;postsynapse#GO:0098794;cell junction#GO:0030054;dendritic tree#GO:0097447;dendrite#GO:0030425 HUMAN|HGNC=2898|UniProtKB=P09622 P09622 DLD PTHR22912:SF151 DISULFIDE OXIDOREDUCTASE DIHYDROLIPOYL DEHYDROGENASE, MITOCHONDRIAL ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265;anion binding#GO:0043168;binding#GO:0005488;flavin adenine dinucleotide binding#GO:0050660;small molecule binding#GO:0036094;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;catalytic activity#GO:0003824;heterocyclic compound binding#GO:1901363;oxidoreductase activity#GO:0016491;nucleotide binding#GO:0000166 small molecule metabolic process#GO:0044281;pyruvate metabolic process#GO:0006090;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;cellular process#GO:0009987 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;oxidoreductase complex#GO:1990204;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex#GO:1990234 oxidoreductase#PC00176 HUMAN|HGNC=30697|UniProtKB=Q8TB96 Q8TB96 ITFG1 PTHR13412:SF0 T-CELL IMMUNOMODULATORY PROTEIN HOMOLOG T-CELL IMMUNOMODULATORY PROTEIN plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=6889|UniProtKB=Q8IW41 Q8IW41 MAPKAPK5 PTHR24349:SF179 SERINE/THREONINE-PROTEIN KINASE MAP KINASE-ACTIVATED PROTEIN KINASE 5 transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;protein kinase binding#GO:0019901;calcium/calmodulin-dependent protein kinase activity#GO:0004683;enzyme binding#GO:0019899;protein serine/threonine kinase activity#GO:0004674;kinase binding#GO:0019900;binding#GO:0005488;protein kinase activity#GO:0004672;protein binding#GO:0005515;phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;calmodulin binding#GO:0005516;transferase activity#GO:0016740;mitogen-activated protein kinase binding#GO:0051019 intracellular signaling cassette#GO:0141124;signaling#GO:0023052;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;Ras protein signal transduction#GO:0007265 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=24188|UniProtKB=Q9BRK5 Q9BRK5 SDF4 PTHR10827:SF98 RETICULOCALBIN 45 KDA CALCIUM-BINDING PROTEIN calcium ion binding#GO:0005509;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;cation binding#GO:0043169;metal ion binding#GO:0046872 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 calmodulin-related#PC00061;calcium-binding protein#PC00060 Gonadotropin-releasing hormone receptor pathway#P06664>AMPK#P06830 HUMAN|HGNC=15822|UniProtKB=Q8N573 Q8N573 OXR1 PTHR23354:SF69 NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED OXIDATION RESISTANCE PROTEIN 1 response to stress#GO:0006950;response to stimulus#GO:0050896;response to oxidative stress#GO:0006979 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=9762|UniProtKB=P51153 P51153 RAB13 PTHR47980:SF42 LD44762P RAS-RELATED PROTEIN RAB-13 export from cell#GO:0140352;endocytic recycling#GO:0032456;localization within membrane#GO:0051668;secretion by cell#GO:0032940;secretion#GO:0046903;cellular localization#GO:0051641;localization#GO:0051179;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;transport#GO:0006810;intracellular transport#GO:0046907;endosomal transport#GO:0016197;vesicle-mediated transport to the plasma membrane#GO:0098876;exocytosis#GO:0006887;establishment of localization#GO:0051234 intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;trans-Golgi network transport vesicle#GO:0030140;endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;coated vesicle#GO:0030135;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;cell periphery#GO:0071944;endomembrane system#GO:0012505;transport vesicle#GO:0030133;cytoplasm#GO:0005737;plasma membrane#GO:0005886;clathrin-coated vesicle#GO:0030136;Golgi-associated vesicle#GO:0005798 HUMAN|HGNC=15473|UniProtKB=Q96PN8 Q96PN8 TSSK3 PTHR24343:SF74 SERINE/THREONINE KINASE TESTIS-SPECIFIC SERINE_THREONINE-PROTEIN KINASE 3 kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 cellular developmental process#GO:0048869;developmental process#GO:0032502;spermatogenesis#GO:0007283;male gamete generation#GO:0048232;cellular process#GO:0009987;multicellular organismal reproductive process#GO:0048609;anatomical structure development#GO:0048856;spermatid development#GO:0007286;sexual reproduction#GO:0019953;spermatid differentiation#GO:0048515;cellular process involved in reproduction in multicellular organism#GO:0022412;reproductive process#GO:0022414;cell development#GO:0048468;gamete generation#GO:0007276;cell differentiation#GO:0030154;germ cell development#GO:0007281;developmental process involved in reproduction#GO:0003006 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=30817|UniProtKB=Q6NTE8 Q6NTE8 MRNIP PTHR15863:SF2 MRN COMPLEX-INTERACTING PROTEIN MRN COMPLEX-INTERACTING PROTEIN chromatin binding#GO:0003682;binding#GO:0005488 response to stress#GO:0006950;cellular process#GO:0009987;signal transduction#GO:0007165;negative regulation of G2/M transition of mitotic cell cycle#GO:0010972;negative regulation of mitotic cell cycle phase transition#GO:1901991;cell cycle checkpoint signaling#GO:0000075;regulation of cell cycle process#GO:0010564;negative regulation of cell cycle#GO:0045786;negative regulation of cell cycle G2/M phase transition#GO:1902750;negative regulation of cell cycle phase transition#GO:1901988;negative regulation of biological process#GO:0048519;cell cycle process#GO:0022402;signal transduction in response to DNA damage#GO:0042770;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of cell cycle#GO:0051726;signaling#GO:0023052;cellular response to stress#GO:0033554;regulation of mitotic cell cycle phase transition#GO:1901990;mitotic G2 DNA damage checkpoint signaling#GO:0007095;negative regulation of mitotic cell cycle#GO:0045930;DNA integrity checkpoint signaling#GO:0031570;regulation of cell cycle G2/M phase transition#GO:1902749;regulation of mitotic cell cycle#GO:0007346;mitotic DNA integrity checkpoint signaling#GO:0044774;mitotic G2/M transition checkpoint#GO:0044818;DNA damage checkpoint signaling#GO:0000077;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;negative regulation of cell cycle process#GO:0010948;DNA damage response#GO:0006974;mitotic cell cycle process#GO:1903047;cell cycle#GO:0007049;mitotic cell cycle checkpoint signaling#GO:0007093;regulation of cell cycle phase transition#GO:1901987;mitotic DNA damage checkpoint signaling#GO:0044773;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;mitotic cell cycle#GO:0000278;regulation of G2/M transition of mitotic cell cycle#GO:0010389;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=2019|UniProtKB=P35523 P35523 CLCN1 PTHR45720:SF4 CHLORIDE CHANNEL PROTEIN 2 CHLORIDE CHANNEL PROTEIN 1 voltage-gated monoatomic anion channel activity#GO:0008308;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;chloride channel activity#GO:0005254;chloride transmembrane transporter activity#GO:0015108;passive transmembrane transporter activity#GO:0022803;monoatomic anion transmembrane transporter activity#GO:0008509;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;voltage-gated channel activity#GO:0022832;monoatomic anion channel activity#GO:0005253;channel activity#GO:0015267;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836 monoatomic anion transport#GO:0006820;chloride transport#GO:0006821;transport#GO:0006810;establishment of localization#GO:0051234;localization#GO:0051179;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 ion channel#PC00133;transporter#PC00227 HUMAN|HGNC=27321|UniProtKB=Q96QK8 Q96QK8 SMIM14 PTHR31019:SF1 SMALL INTEGRAL MEMBRANE PROTEIN 14 SMALL INTEGRAL MEMBRANE PROTEIN 14 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=6759|UniProtKB=P29966 P29966 MARCKS PTHR14353:SF9 MYRISTOYLATED ALANINE-RICH C-KINASE SUBSTRATE MARCKS MYRISTOYLATED ALANINE-RICH C-KINASE SUBSTRATE binding#GO:0005488;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;actin filament binding#GO:0051015;protein binding#GO:0005515;protein-containing complex binding#GO:0044877 cellular component organization#GO:0016043;central nervous system development#GO:0007417;actin cytoskeleton organization#GO:0030036;animal gross anatomical part developmental process#GO:0160108;actin filament-based process#GO:0030029;anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;system development#GO:0048731;organelle organization#GO:0006996;cellular process#GO:0009987;multicellular organismal process#GO:0032501;cytoskeleton organization#GO:0007010;nervous system development#GO:0007399;developmental process#GO:0032502;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;actin filament organization#GO:0007015 cell periphery#GO:0071944;membrane#GO:0016020;actin cytoskeleton#GO:0015629;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;actin filament bundle#GO:0032432 HUMAN|HGNC=11411|UniProtKB=O76039 O76039 CDKL5 PTHR24056:SF111 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE-LIKE 5 phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=9322|UniProtKB=P53041 P53041 PPP5C PTHR45668:SF5 SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED SERINE_THREONINE-PROTEIN PHOSPHATASE 5 catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721 nucleus#GO:0005634;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 protein phosphatase#PC00195 HUMAN|HGNC=8209|UniProtKB=Q8NGS2 Q8NGS2 OR1J2 PTHR48001:SF9 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 1J2 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=54|UniProtKB=O15438 O15438 ABCC3 PTHR24223:SF405 ATP-BINDING CASSETTE SUB-FAMILY C ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 3 transporter activity#GO:0005215;ATP-dependent activity#GO:0140657;transmembrane transporter activity#GO:0022857;ATPase-coupled transmembrane transporter activity#GO:0042626;active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399;xenobiotic transmembrane transporter activity#GO:0042910 cellular process#GO:0009987;transport#GO:0006810;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179 basal plasma membrane#GO:0009925;cell periphery#GO:0071944;basal part of cell#GO:0045178;basolateral plasma membrane#GO:0016323;membrane#GO:0016020;plasma membrane#GO:0005886;plasma membrane region#GO:0098590;cellular anatomical structure#GO:0110165 ATP-binding cassette (ABC) transporter#PC00003 HUMAN|HGNC=25192|UniProtKB=Q96BM9 Q96BM9 ARL8A PTHR45732:SF4 ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8 ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8A vesicle-mediated transport#GO:0016192;cytoskeleton-dependent intracellular transport#GO:0030705;axo-dendritic transport#GO:0008088;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;microtubule-based process#GO:0007017;endosomal transport#GO:0016197;intracellular transport#GO:0046907;transport#GO:0006810;vacuolar transport#GO:0007034;microtubule-based movement#GO:0007018;cellular localization#GO:0051641;localization#GO:0051179;anterograde axonal transport#GO:0008089;lysosomal transport#GO:0007041;axonal transport#GO:0098930;microtubule-based transport#GO:0099111 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;lysosome#GO:0005764;lytic vacuole membrane#GO:0098852;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;vacuole#GO:0005773;lysosomal membrane#GO:0005765;membrane#GO:0016020;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;vacuolar membrane#GO:0005774;lytic vacuole#GO:0000323 HUMAN|HGNC=53878|UniProtKB=A0AAG2UUX9 A0AAG2UUX9 CNTNAP3C PTHR15036:SF36 PIKACHURIN-LIKE PROTEIN CONTACTIN ASSOCIATED PROTEIN FAMILY MEMBER 3C-RELATED system development#GO:0048731;cell communication#GO:0007154;anatomical structure development#GO:0048856;animal gross anatomical part developmental process#GO:0160108;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;multicellular organism development#GO:0007275;developmental process#GO:0032502;biological regulation#GO:0065007;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;signal transduction#GO:0007165;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;synapse#GO:0045202;cell junction#GO:0030054;plasma membrane#GO:0005886 cell adhesion molecule#PC00069 HUMAN|HGNC=3121|UniProtKB=Q66K89 Q66K89 E4F1 PTHR24390:SF94 ZINC FINGER PROTEIN TRANSCRIPTION FACTOR E4F1 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218 HUMAN|HGNC=26765|UniProtKB=Q68DI1 Q68DI1 ZNF776 PTHR24377:SF725 IP01015P-RELATED ZINC FINGER PROTEIN 776 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=25092|UniProtKB=Q7L2R6 Q7L2R6 ZNF765 PTHR24377:SF765 IP01015P-RELATED ZINC FINGER PROTEIN 765 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=15533|UniProtKB=Q9C004 Q9C004 SPRY4 PTHR12365:SF6 SPROUTY PROTEIN SPROUTY HOMOLOG 4 enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;kinase inhibitor activity#GO:0019210;protein kinase inhibitor activity#GO:0004860;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;protein kinase regulator activity#GO:0019887;enzyme inhibitor activity#GO:0004857 regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of ERBB signaling pathway#GO:1901184;negative regulation of MAPK cascade#GO:0043409;negative regulation of biological process#GO:0048519;regulation of Ras protein signal transduction#GO:0046578;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;regulation of signal transduction#GO:0009966;regulation of fibroblast growth factor receptor signaling pathway#GO:0040036;biological regulation#GO:0065007;regulation of cellular response to growth factor stimulus#GO:0090287;negative regulation of signal transduction#GO:0009968;regulation of epidermal growth factor receptor signaling pathway#GO:0042058;negative regulation of ERK1 and ERK2 cascade#GO:0070373;regulation of ERK1 and ERK2 cascade#GO:0070372;negative regulation of response to stimulus#GO:0048585;regulation of small GTPase mediated signal transduction#GO:0051056;regulation of MAPK cascade#GO:0043408;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523 scaffold/adaptor protein#PC00226 EGF receptor signaling pathway#P00018>SPRY#G01511;EGF receptor signaling pathway#P00018>Spry#P00541;FGF signaling pathway#P00021>Spry#P00626 HUMAN|HGNC=14430|UniProtKB=Q8WWT9 Q8WWT9 SLC13A3 PTHR10283:SF62 SOLUTE CARRIER FAMILY 13 MEMBER NA(+)_DICARBOXYLATE COTRANSPORTER 3 monoatomic cation transmembrane transporter activity#GO:0008324;sodium:dicarboxylate symporter activity#GO:0017153;symporter activity#GO:0015293;citrate transmembrane transporter activity#GO:0015137;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;solute:sodium symporter activity#GO:0015370;carboxylic acid transmembrane transporter activity#GO:0046943;C4-dicarboxylate transmembrane transporter activity#GO:0015556;active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;succinate transmembrane transporter activity#GO:0015141;solute:monoatomic cation symporter activity#GO:0015294;dicarboxylic acid transmembrane transporter activity#GO:0005310;transmembrane transporter activity#GO:0022857 localization#GO:0051179;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;citrate transport#GO:0015746;tricarboxylic acid transport#GO:0006842;organic acid transport#GO:0015849;transport#GO:0006810;C4-dicarboxylate transport#GO:0015740;carboxylic acid transport#GO:0046942;succinate transport#GO:0015744;carboxylic acid transmembrane transport#GO:1905039;dicarboxylic acid transport#GO:0006835;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227;secondary carrier transporter#PC00258 HUMAN|HGNC=17598|UniProtKB=Q9Y385 Q9Y385 UBE2J1 PTHR24068:SF581 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2 J1 aminoacyltransferase activity#GO:0016755;ubiquitin conjugating enzyme activity#GO:0061631;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-like protein conjugating enzyme activity#GO:0061650;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746 protein ubiquitination#GO:0016567;proteasomal protein catabolic process#GO:0010498;post-translational protein modification#GO:0043687;response to chemical#GO:0042221;cellular process#GO:0009987;response to stress#GO:0006950;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;catabolic process#GO:0009056;response to stimulus#GO:0050896;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;protein modification process#GO:0036211;ERAD pathway#GO:0036503;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;protein modification by small protein conjugation or removal#GO:0070647;response to endoplasmic reticulum stress#GO:0034976 endoplasmic reticulum subcompartment#GO:0098827;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ubiquitin ligase complex#GO:0000151;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;membrane protein complex#GO:0098796;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;transferase complex#GO:1990234;organelle membrane#GO:0031090;intracellular protein-containing complex#GO:0140535;endoplasmic reticulum protein-containing complex#GO:0140534;membrane#GO:0016020;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasm#GO:0005737 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=4374|UniProtKB=O60234 O60234 GMFG PTHR11249:SF4 GLIAL FACTOR NATURATION FACTOR GLIA MATURATION FACTOR GAMMA binding#GO:0005488;protein-containing complex binding#GO:0044877 regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;negative regulation of supramolecular fiber organization#GO:1902904;regulation of cellular process#GO:0050794;negative regulation of biological process#GO:0048519;negative regulation of organelle organization#GO:0010639;negative regulation of cellular component organization#GO:0051129;regulation of biological process#GO:0050789;regulation of supramolecular fiber organization#GO:1902903;regulation of organelle organization#GO:0033043;negative regulation of cytoskeleton organization#GO:0051494;actin filament-based process#GO:0030029;biological regulation#GO:0065007;regulation of actin cytoskeleton organization#GO:0032956;cellular process#GO:0009987;regulation of actin filament organization#GO:0110053;regulation of actin nucleation#GO:0051125;regulation of actin filament-based process#GO:0032970;negative regulation of cellular process#GO:0048523 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cortical actin cytoskeleton#GO:0030864;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cortical cytoskeleton#GO:0030863;actin cytoskeleton#GO:0015629;cell periphery#GO:0071944;cell cortex#GO:0005938;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 intercellular signal molecule#PC00207 HUMAN|HGNC=20853|UniProtKB=Q96MT1 Q96MT1 RNF145 PTHR22763:SF167 RING ZINC FINGER PROTEIN RING FINGER PROTEIN 145 catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630 proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=26970|UniProtKB=Q5RI15 Q5RI15 COX20 PTHR31586:SF2 CYTOCHROME C OXIDASE PROTEIN 20 CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX20, MITOCHONDRIAL cytochrome complex assembly#GO:0017004;mitochondrial respiratory chain complex IV assembly#GO:0033617;respiratory chain complex IV assembly#GO:0008535;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;mitochondrion organization#GO:0007005;mitochondrial respiratory chain complex assembly#GO:0033108;cellular component assembly#GO:0022607 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739 oxidoreductase#PC00176;oxidase#PC00175 HUMAN|HGNC=14934|UniProtKB=Q8N6T7 Q8N6T7 SIRT6 PTHR11085:SF19 NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-6 deacetylase activity#GO:0019213;histone modifying activity#GO:0140993;acyltransferase activity#GO:0016746;transcription regulator activity#GO:0140110;NAD-dependent protein lysine deacetylase activity#GO:0034979;catalytic activity, acting on a protein#GO:0140096;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714;histone deacetylase activity#GO:0004407;transferase activity#GO:0016740;catalytic activity#GO:0003824;deacylase activity#GO:0160215 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=24869|UniProtKB=Q9H3Q3 Q9H3Q3 GAL3ST2 PTHR14647:SF55 GALACTOSE-3-O-SULFOTRANSFERASE GALACTOSE-3-O-SULFOTRANSFERASE 2 transferase activity, transferring sulphur-containing groups#GO:0016782;sulfotransferase activity#GO:0008146;catalytic activity#GO:0003824;transferase activity#GO:0016740 biosynthetic process#GO:0009058;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152 transferase#PC00220 HUMAN|HGNC=18581|UniProtKB=Q8N485 Q8N485 LIX1 PTHR31139:SF5 ECTOPIC P GRANULES PROTEIN 5 HOMOLOG PROTEIN LIMB EXPRESSION 1 HOMOLOG cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;actin filament-based process#GO:0030029;actin cytoskeleton organization#GO:0030036;cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=13527|UniProtKB=Q9Y5K8 Q9Y5K8 ATP6V1D PTHR11671:SF5 V-TYPE ATP SYNTHASE SUBUNIT D V-TYPE PROTON ATPASE SUBUNIT D ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657;monoatomic cation transmembrane transporter activity#GO:0008324;proton transmembrane transporter activity#GO:0015078;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399 cellular homeostasis#GO:0019725;regulation of biological quality#GO:0065008;intracellular chemical homeostasis#GO:0055082;vacuolar acidification#GO:0007035;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;regulation of intracellular pH#GO:0051453;regulation of pH#GO:0006885;biological regulation#GO:0065007;homeostatic process#GO:0042592;monoatomic ion homeostasis#GO:0050801;intracellular monoatomic ion homeostasis#GO:0006873 membrane#GO:0016020;vacuole#GO:0005773;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;proton-transporting two-sector ATPase complex#GO:0016469;proton-transporting V-type ATPase complex#GO:0033176;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;transporter complex#GO:1990351;vacuolar membrane#GO:0005774;cation-transporting ATPase complex#GO:0090533;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ATPase complex#GO:1904949;membrane-bounded organelle#GO:0043227;ATPase dependent transmembrane transport complex#GO:0098533;intracellular anatomical structure#GO:0005622;transmembrane transporter complex#GO:1902495 ATP synthase#PC00002 HUMAN|HGNC=4466|UniProtKB=P47775 P47775 GPR12 PTHR22750:SF8 G-PROTEIN COUPLED RECEPTOR G PROTEIN-COUPLED RECEPTOR 12 transmembrane signaling receptor activity#GO:0004888;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021 HUMAN|HGNC=11237|UniProtKB=Q9UQ90 Q9UQ90 SPG7 PTHR43655:SF8 ATP-DEPENDENT PROTEASE MITOCHONDRIAL INNER MEMBRANE M-AAA PROTEASE COMPONENT PARAPLEGIN metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;proteolysis#GO:0006508;metabolic process#GO:0008152;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059 protein-containing complex#GO:0032991;mitochondrial protein-containing complex#GO:0098798;peptidase complex#GO:1905368;cytoplasm#GO:0005737;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;mitochondrial membrane#GO:0031966;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;organelle membrane#GO:0031090;inner mitochondrial membrane protein complex#GO:0098800;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;membrane protein complex#GO:0098796;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 metalloprotease#PC00153;protease#PC00190 HUMAN|HGNC=11984|UniProtKB=Q6ZVM7 Q6ZVM7 TOM1L2 PTHR13856:SF31 VHS DOMAIN CONTAINING PROTEIN FAMILY TOM1-LIKE PROTEIN 2 protein binding#GO:0005515;clathrin binding#GO:0030276;binding#GO:0005488 cell communication#GO:0007154;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789 cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;membrane#GO:0016020;intracellular vesicle#GO:0097708 HUMAN|HGNC=37263|UniProtKB=B9EJG8 B9EJG8 TMEM150C PTHR21324:SF7 FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED TRANSMEMBRANE PROTEIN 150C cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=25845|UniProtKB=Q86UY6 Q86UY6 NAA40 PTHR20531:SF1 N-ALPHA-ACETYLTRANSFERASE 40 N-ALPHA-ACETYLTRANSFERASE 40 catalytic activity, acting on a protein#GO:0140096;protein N-acetyltransferase activity#GO:0034212;protein-N-terminal amino-acid acetyltransferase activity#GO:0004596;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein N-acyltransferase activity#GO:0140186;histone acetyltransferase activity#GO:0004402;histone modifying activity#GO:0140993;protein-lysine-acetyltransferase activity#GO:0061733;acetyltransferase activity#GO:0016407;acyltransferase activity#GO:0016746;N-acetyltransferase activity#GO:0008080 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=1839|UniProtKB=Q9NZK5 Q9NZK5 ADA2 PTHR11409:SF39 ADENOSINE DEAMINASE ADENOSINE DEAMINASE 2 catalytic activity#GO:0003824;hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;adenosine deaminase activity#GO:0004000;deaminase activity#GO:0019239;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814 purine-containing compound metabolic process#GO:0072521;primary metabolic process#GO:0044238;nucleobase-containing small molecule catabolic process#GO:0034656;small molecule catabolic process#GO:0044282;carbohydrate derivative catabolic process#GO:1901136;nucleoside metabolic process#GO:0009116;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;purine nucleoside metabolic process#GO:0042278;purine-containing compound biosynthetic process#GO:0072522;nucleoside catabolic process#GO:0009164;cellular process#GO:0009987;adenosine metabolic process#GO:0046085;carbohydrate derivative metabolic process#GO:1901135;glycosyl compound catabolic process#GO:1901658;nucleobase-containing compound catabolic process#GO:0034655;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;small molecule biosynthetic process#GO:0044283;purine nucleobase metabolic process#GO:0006144;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;nucleobase metabolic process#GO:0009112;nucleobase-containing small molecule metabolic process#GO:0055086;purine nucleoside catabolic process#GO:0006152;carbohydrate derivative biosynthetic process#GO:1901137;purine-containing compound catabolic process#GO:0072523 cytosol#GO:0005829;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 deaminase#PC00088 HUMAN|HGNC=15372|UniProtKB=Q8NGB9 Q8NGB9 OR4F6 PTHR48002:SF122 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 4F6 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=25055|UniProtKB=Q9H4I9 Q9H4I9 SMDT1 PTHR33904:SF1 ESSENTIAL MCU REGULATOR, MITOCHONDRIAL ESSENTIAL MCU REGULATOR, MITOCHONDRIAL calcium ion homeostasis#GO:0055074;inorganic ion homeostasis#GO:0098771;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;calcium ion transmembrane transport#GO:0070588;intracellular monoatomic ion homeostasis#GO:0006873;mitochondrial calcium ion homeostasis#GO:0051560;homeostatic process#GO:0042592;metal ion transport#GO:0030001;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;transport#GO:0006810;establishment of localization#GO:0051234;calcium ion transport#GO:0006816;cellular homeostasis#GO:0019725;intracellular calcium ion homeostasis#GO:0006874;intracellular chemical homeostasis#GO:0055082;mitochondrial calcium ion transmembrane transport#GO:0006851;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655 organelle membrane#GO:0031090;transporter complex#GO:1990351;cation channel complex#GO:0034703;inner mitochondrial membrane protein complex#GO:0098800;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;mitochondrial protein-containing complex#GO:0098798;mitochondrial membrane#GO:0031966;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;transmembrane transporter complex#GO:1902495;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;calcium channel complex#GO:0034704;membrane protein complex#GO:0098796;organelle envelope#GO:0031967 HUMAN|HGNC=26216|UniProtKB=Q08AI8 Q08AI8 MAB21L4 PTHR10656:SF7 CELL FATE DETERMINING PROTEIN MAB21-RELATED PROTEIN MAB-21-LIKE 4 transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleotidyltransferase activity#GO:0016779;transferase activity, transferring phosphorus-containing groups#GO:0016772;nucleic acid binding#GO:0003676;binding#GO:0005488;chromatin binding#GO:0003682;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690 regulation of biosynthetic process#GO:0009889;regulation of innate immune response#GO:0045088;positive regulation of response to biotic stimulus#GO:0002833;negative regulation of cellular process#GO:0048523;regulation of DNA repair#GO:0006282;regulation of response to stimulus#GO:0048583;DNA damage response#GO:0006974;positive regulation of immune response#GO:0050778;positive regulation of defense response#GO:0031349;negative regulation of response to stimulus#GO:0048585;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;regulation of metabolic process#GO:0019222;regulation of cytokine production#GO:0001817;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of double-strand break repair#GO:2000779;regulation of defense response#GO:0031347;regulation of immune response#GO:0050776;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of macromolecule metabolic process#GO:0060255;positive regulation of type I interferon production#GO:0032481;negative regulation of DNA recombination#GO:0045910;cellular response to stimulus#GO:0051716;regulation of response to external stimulus#GO:0032101;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of immune system process#GO:0002684;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;positive regulation of macromolecule biosynthetic process#GO:0010557;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;immune system process#GO:0002376;cellular response to chemical stimulus#GO:0070887;response to stimulus#GO:0050896;negative regulation of biological process#GO:0048519;positive regulation of multicellular organismal process#GO:0051240;regulation of biological process#GO:0050789;regulation of gene expression#GO:0010468;positive regulation of gene expression#GO:0010628;regulation of response to stress#GO:0080134;cellular response to nitrogen compound#GO:1901699;negative regulation of DNA metabolic process#GO:0051053;regulation of macromolecule biosynthetic process#GO:0010556;activation of innate immune response#GO:0002218;positive regulation of innate immune response#GO:0045089;cell communication#GO:0007154;positive regulation of biosynthetic process#GO:0009891;response to nitrogen compound#GO:1901698;positive regulation of cytokine production#GO:0001819;regulation of response to biotic stimulus#GO:0002831;positive regulation of response to external stimulus#GO:0032103;negative regulation of double-strand break repair via homologous recombination#GO:2000042;response to chemical#GO:0042221;regulation of multicellular organismal process#GO:0051239;response to stress#GO:0006950;positive regulation of metabolic process#GO:0009893;regulation of cellular response to stress#GO:0080135;regulation of DNA recombination#GO:0000018;cellular response to stress#GO:0033554;regulation of double-strand break repair via homologous recombination#GO:0010569;signaling#GO:0023052;negative regulation of metabolic process#GO:0009892;regulation of DNA metabolic process#GO:0051052 cytosol#GO:0005829;chromosome#GO:0005694;site of double-strand break#GO:0035861;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;site of DNA damage#GO:0090734;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 nucleotidyltransferase#PC00174;transferase#PC00220 HUMAN|HGNC=11791|UniProtKB=Q07283 Q07283 TCHH PTHR34855:SF1 TRICHOHYALIN TRICHOHYALIN molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 cytoskeleton organization#GO:0007010;intermediate filament cytoskeleton organization#GO:0045104;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;cellular component organization or biogenesis#GO:0071840;intermediate filament organization#GO:0045109;intermediate filament-based process#GO:0045103 HUMAN|HGNC=18266|UniProtKB=Q8N8Y2 Q8N8Y2 ATP6V0D2 PTHR11028:SF2 VACUOLAR ATP SYNTHASE SUBUNIT AC39 V-TYPE PROTON ATPASE SUBUNIT D 2 proton transmembrane transporter activity#GO:0015078;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic ion transmembrane transporter activity#GO:0015075;active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399;ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;monoatomic cation transmembrane transporter activity#GO:0008324 biological regulation#GO:0065007;monoatomic ion homeostasis#GO:0050801;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;establishment of localization#GO:0051234;vacuolar acidification#GO:0007035;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;intracellular transport#GO:0046907;vacuolar transport#GO:0007034;monoatomic cation homeostasis#GO:0055080;transport#GO:0006810;chemical homeostasis#GO:0048878;intracellular monoatomic cation homeostasis#GO:0030003;homeostatic process#GO:0042592;intracellular monoatomic ion homeostasis#GO:0006873;localization#GO:0051179;cellular localization#GO:0051641;regulation of biological quality#GO:0065008;regulation of pH#GO:0006885;regulation of intracellular pH#GO:0051453 vacuolar proton-transporting V-type ATPase complex#GO:0016471;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;transmembrane transporter complex#GO:1902495;plasma membrane protein complex#GO:0098797;cation-transporting ATPase complex#GO:0090533;vesicle#GO:0031982;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;organelle membrane#GO:0031090;proton-transporting V-type ATPase complex#GO:0033176;vacuolar membrane#GO:0005774;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;endomembrane system#GO:0012505;endosome#GO:0005768;ATPase complex#GO:1904949;intracellular organelle#GO:0043229;ATPase dependent transmembrane transport complex#GO:0098533;early endosome#GO:0005769;lysosome#GO:0005764;intracellular vesicle#GO:0097708;lytic vacuole membrane#GO:0098852;cellular anatomical structure#GO:0110165;organelle#GO:0043226;proton-transporting two-sector ATPase complex#GO:0016469;bounding membrane of organelle#GO:0098588;transporter complex#GO:1990351;lytic vacuole#GO:0000323;lysosomal membrane#GO:0005765;cytoplasm#GO:0005737;vacuole#GO:0005773;protein-containing complex#GO:0032991 ATP synthase#PC00002 HUMAN|HGNC=26666|UniProtKB=Q32P44 Q32P44 EML3 PTHR13720:SF15 WD-40 REPEAT PROTEIN ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 3 protein binding#GO:0005515;microtubule binding#GO:0008017;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631 cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;cytoskeleton organization#GO:0007010 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;spindle#GO:0005819;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;mitotic spindle#GO:0072686;microtubule cytoskeleton#GO:0015630 microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=1695|UniProtKB=P09564 P09564 CD7 PTHR15343:SF0 CD7 T-CELL ANTIGEN CD7 HUMAN|HGNC=33185|UniProtKB=A6NMT0 A6NMT0 DBX1 PTHR24331:SF6 DBX HOMEOBOX PROTEIN DBX1 cell differentiation#GO:0030154;central nervous system development#GO:0007417;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;animal gross anatomical part developmental process#GO:0160108;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;nervous system development#GO:0007399;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;multicellular organism development#GO:0007275;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;developmental process#GO:0032502 HUMAN|HGNC=5961|UniProtKB=Q9Y6K9 Q9Y6K9 IKBKG PTHR31553:SF3 NF-KAPPA-B ESSENTIAL MODULATOR NF-KAPPA-B ESSENTIAL MODULATOR protein binding#GO:0005515;modification-dependent protein binding#GO:0140030;polyubiquitin modification-dependent protein binding#GO:0031593;K63-linked polyubiquitin modification-dependent protein binding#GO:0070530;binding#GO:0005488 positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;positive regulation of canonical NF-kappaB signal transduction#GO:0043123;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of canonical NF-kappaB signal transduction#GO:0043122;positive regulation of response to stimulus#GO:0048584;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646 catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;protein kinase complex#GO:1902911;nucleus#GO:0005634;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 HUMAN|HGNC=26518|UniProtKB=Q6GTS8 Q6GTS8 PM20D1 PTHR45962:SF4 N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1 N-FATTY-ACYL-AMINO ACID SYNTHASE_HYDROLASE PM20D1 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;catalytic activity#GO:0003824;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity#GO:0016787 multicellular organismal-level homeostasis#GO:0048871;metabolic process#GO:0008152;temperature homeostasis#GO:0001659;adaptive thermogenesis#GO:1990845;lipid metabolic process#GO:0006629;multicellular organismal process#GO:0032501;homeostatic process#GO:0042592;primary metabolic process#GO:0044238;cellular process#GO:0009987 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HUMAN|HGNC=1677|UniProtKB=P20963 P20963 CD247 PTHR10035:SF2 T-CELL SURFACE GLYCOPROTEIN CD3 ZETA CHAIN T-CELL SURFACE GLYCOPROTEIN CD3 ZETA CHAIN regulation of biological process#GO:0050789;immune response-regulating signaling pathway#GO:0002764;cellular response to stimulus#GO:0051716;signaling#GO:0023052;immune response-activating cell surface receptor signaling pathway#GO:0002429;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of immune response#GO:0050776;immune system process#GO:0002376;cell communication#GO:0007154;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;cellular process#GO:0009987;positive regulation of immune system process#GO:0002684;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;antigen receptor-mediated signaling pathway#GO:0050851;positive regulation of response to stimulus#GO:0048584;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166;T cell receptor signaling pathway#GO:0050852;immune response-activating signaling pathway#GO:0002757 plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;membrane#GO:0016020;signaling receptor complex#GO:0043235 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 T cell activation#P00053>TCR zeta#P01296 HUMAN|HGNC=25010|UniProtKB=Q9BVV7 Q9BVV7 TIMM21 PTHR13032:SF6 MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21 MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21 mitochondrial transmembrane transport#GO:1990542;cellular localization#GO:0051641;transmembrane transport#GO:0055085;localization#GO:0051179;protein transport#GO:0015031;protein localization to mitochondrion#GO:0070585;protein localization to organelle#GO:0033365;mitochondrial transport#GO:0006839;intracellular transport#GO:0046907;protein transmembrane transport#GO:0071806;intracellular protein transport#GO:0006886;transport#GO:0006810;protein transmembrane import into intracellular organelle#GO:0044743;intracellular protein transmembrane transport#GO:0065002;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;protein import into mitochondrial matrix#GO:0030150;mitochondrial protein import pathway#GO:7770058 mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrial membrane#GO:0031966;TIM23 mitochondrial import inner membrane translocase complex#GO:0005744;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;cytoplasm#GO:0005737;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;inner mitochondrial membrane protein complex#GO:0098800;organelle membrane#GO:0031090;mitochondrion#GO:0005739;organelle envelope#GO:0031967;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=8638|UniProtKB=Q92831 Q92831 KAT2B PTHR45750:SF2 GH11602P HISTONE ACETYLTRANSFERASE KAT2B histone acetyltransferase activity#GO:0004402;histone modifying activity#GO:0140993;protein N-acyltransferase activity#GO:0140186;N-acetyltransferase activity#GO:0008080;acetyltransferase activity#GO:0016407;protein-lysine-acetyltransferase activity#GO:0061733;acyltransferase activity#GO:0016746;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;protein N-acetyltransferase activity#GO:0034212;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740 cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;chromatin remodeling#GO:0006338;positive regulation of RNA metabolic process#GO:0051254;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;biological regulation#GO:0065007;chromatin organization#GO:0006325;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;positive regulation of transcription by RNA polymerase II#GO:0045944;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 chromosome#GO:0005694;cellular anatomical structure#GO:0110165;organelle#GO:0043226;protein acetyltransferase complex#GO:0031248;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;acetyltransferase complex#GO:1902493;SAGA-type complex#GO:0070461;chromatin#GO:0000785;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;histone acetyltransferase complex#GO:0000123;membraneless organelle#GO:0043228 p53 pathway#P00059>PCAF#P04629;Gonadotropin-releasing hormone receptor pathway#P06664>Pcaf#P06715 HUMAN|HGNC=7167|UniProtKB=O60882 O60882 MMP20 PTHR10201:SF125 MATRIX METALLOPROTEINASE MATRIX METALLOPROTEINASE-20 peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 anatomical structure formation involved in morphogenesis#GO:0048646;cellular component organization or biogenesis#GO:0071840;animal organ development#GO:0048513;developmental process#GO:0032502;metabolic process#GO:0008152;odontogenesis of dentin-containing tooth#GO:0042475;cellular process#GO:0009987;amelogenesis#GO:0097186;external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198;anatomical structure development#GO:0048856;extracellular structure organization#GO:0043062;animal gross anatomical part developmental process#GO:0160108;odontogenesis#GO:0042476;catabolic process#GO:0009056;animal organ morphogenesis#GO:0009887;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 metalloprotease#PC00153 Alzheimer disease-presenilin pathway#P00004>Matrix metalloprotease#P00130 HUMAN|HGNC=16831|UniProtKB=O95153 O95153 TSPOAP1 PTHR14234:SF20 RIM BINDING PROTEIN-RELATED PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR-ASSOCIATED PROTEIN 1 signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515 mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HUMAN|HGNC=20087|UniProtKB=Q8TAM2 Q8TAM2 TTC8 PTHR44177:SF1 TETRATRICOPEPTIDE REPEAT PROTEIN 8 TETRATRICOPEPTIDE REPEAT PROTEIN 8 cell projection organization#GO:0030030;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;cellular component organization#GO:0016043;cilium assembly#GO:0060271;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cell projection assembly#GO:0030031;non-motile cilium assembly#GO:1905515;cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782;organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031 plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cilium#GO:0005929;intracellular organelle#GO:0043229;non-motile cilium#GO:0097730;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;BBSome#GO:0034464;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;membraneless organelle#GO:0043228 HUMAN|HGNC=5886|UniProtKB=A0A075B6I3 A0A075B6I3 IGLV11-55 PTHR23267:SF506 IMMUNOGLOBULIN LIGHT CHAIN NON-FUNCTIONAL IMMUNOGLOBULIN LAMBDA VARIABLE 11-55-RELATED immune response#GO:0006955;immune system process#GO:0002376;response to stimulus#GO:0050896 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=14678|UniProtKB=Q96CX2 Q96CX2 KCTD12 PTHR14499:SF29 POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD12 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 multicellular organism development#GO:0007275;regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of anatomical structure morphogenesis#GO:0022603;developmental process#GO:0032502;regulation of response to stimulus#GO:0048583;regulation of G protein-coupled receptor signaling pathway#GO:0008277;regulation of cell projection organization#GO:0031344;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;regulation of neuron projection development#GO:0010975;system development#GO:0048731;anatomical structure development#GO:0048856;regulation of signaling#GO:0023051;animal gross anatomical part developmental process#GO:0160108;regulation of developmental process#GO:0050793;regulation of cell communication#GO:0010646;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of dendrite development#GO:0050773;regulation of biological process#GO:0050789;regulation of dendrite morphogenesis#GO:0048814 presynaptic active zone membrane#GO:0048787;postsynapse#GO:0098794;cellular anatomical structure#GO:0110165;synapse#GO:0045202;postsynaptic membrane#GO:0045211;membrane#GO:0016020;cell periphery#GO:0071944;presynapse#GO:0098793;protein-containing complex#GO:0032991;plasma membrane region#GO:0098590;presynaptic membrane#GO:0042734;plasma membrane#GO:0005886;signaling receptor complex#GO:0043235;synaptic membrane#GO:0097060;presynaptic active zone#GO:0048786;cell junction#GO:0030054 scaffold/adaptor protein#PC00226 HUMAN|HGNC=38058|UniProtKB=A0A096LNP1 A0A096LNP1 DEFB131B PTHR47900:SF2 BETA-DEFENSIN 131A BETA-DEFENSIN 131B extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 antimicrobial response protein#PC00051 HUMAN|HGNC=318|UniProtKB=P20933 P20933 AGA PTHR10188:SF50 L-ASPARAGINASE N(4)-(BETA-N-ACETYLGLUCOSAMINYL)-L-ASPARAGINASE catalytic activity#GO:0003824;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810 organelle#GO:0043226;cellular anatomical structure#GO:0110165;vacuole#GO:0005773;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;lysosome#GO:0005764;lytic vacuole#GO:0000323;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 protein modifying enzyme#PC00260;protease#PC00190 HUMAN|HGNC=25146|UniProtKB=A1A4F0 A1A4F0 SLC66A1LP PTHR16201:SF42 SEVEN TRANSMEMBRANE PROTEIN 1-RELATED LYSOSOMAL AMINO ACID TRANSPORTER 1 HOMOLOG basic amino acid transmembrane transporter activity#GO:0015174;L-amino acid transmembrane transporter activity#GO:0015179;amino acid transmembrane transporter activity#GO:0015171;carboxylic acid transmembrane transporter activity#GO:0046943;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;establishment of localization#GO:0051234;vacuolar transmembrane transport#GO:0034486;carboxylic acid transport#GO:0046942;transport#GO:0006810;amino acid transport#GO:0006865;chemical homeostasis#GO:0048878;organic acid transport#GO:0015849;cellular process#GO:0009987;nitrogen compound transport#GO:0071705;L-amino acid transport#GO:0015807;amino acid transmembrane transport#GO:0003333;transmembrane transport#GO:0055085;localization#GO:0051179;carboxylic acid transmembrane transport#GO:1905039;homeostatic process#GO:0042592;L-alpha-amino acid transmembrane transport#GO:1902475 lytic vacuole#GO:0000323;vacuolar membrane#GO:0005774;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane#GO:0016020;lysosomal membrane#GO:0005765;vacuole#GO:0005773;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;lytic vacuole membrane#GO:0098852;lysosome#GO:0005764;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=32057|UniProtKB=Q5T870 Q5T870 PRR9 PTHR48427:SF1 PROLINE-RICH PROTEIN 9 PROLINE-RICH PROTEIN 9 HUMAN|HGNC=20273|UniProtKB=Q9Y3B6 Q9Y3B6 EMC9 PTHR12941:SF12 ER MEMBRANE PROTEIN COMPLEX ER MEMBRANE PROTEIN COMPLEX SUBUNIT 9 membrane insertase activity#GO:0032977;protein carrier activity#GO:0140597;molecular carrier activity#GO:0140104 cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;protein insertion into membrane#GO:0051205;tail-anchored membrane protein insertion into ER membrane#GO:0071816;membrane organization#GO:0061024;endomembrane system organization#GO:0010256;organelle organization#GO:0006996;establishment of protein localization to membrane#GO:0090150;macromolecule localization#GO:0033036;establishment of protein localization#GO:0045184;cellular process#GO:0009987;localization#GO:0051179;cellular localization#GO:0051641;localization within membrane#GO:0051668;protein localization to organelle#GO:0033365;cellular component organization#GO:0016043;protein insertion into ER membrane#GO:0045048;endoplasmic reticulum organization#GO:0007029 intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane protein complex#GO:0098796;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;EMC complex#GO:0072546;cytoplasm#GO:0005737;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;membrane#GO:0016020;endoplasmic reticulum protein-containing complex#GO:0140534;organelle membrane#GO:0031090;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789 HUMAN|HGNC=6233|UniProtKB=P48547 P48547 KCNC1 PTHR11537:SF87 VOLTAGE-GATED POTASSIUM CHANNEL VOLTAGE-GATED POTASSIUM CHANNEL KCNC1 voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;potassium channel activity#GO:0005267 monoatomic cation transmembrane transport#GO:0098655;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813;cellular process#GO:0009987;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;transport#GO:0006810;metal ion transport#GO:0030001;action potential#GO:0001508;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085 dendrite#GO:0030425;axon#GO:0030424;dendritic tree#GO:0097447;transmembrane transporter complex#GO:1902495;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;distal axon#GO:0150034;plasma membrane bounded cell projection#GO:0120025;neuronal cell body#GO:0043025;neuron projection terminus#GO:0044306;voltage-gated potassium channel complex#GO:0008076;neuron projection membrane#GO:0032589;axon terminus#GO:0043679;membrane#GO:0016020;cell periphery#GO:0071944;monoatomic ion channel complex#GO:0034702;plasma membrane region#GO:0098590;presynaptic membrane#GO:0042734;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;postsynaptic membrane#GO:0045211;leading edge membrane#GO:0031256;cell projection membrane#GO:0031253;postsynapse#GO:0098794;cell body#GO:0044297;cellular anatomical structure#GO:0110165;synapse#GO:0045202;cell projection#GO:0042995;synaptic membrane#GO:0097060;cation channel complex#GO:0034703;transporter complex#GO:1990351;cell junction#GO:0030054;cell leading edge#GO:0031252;presynapse#GO:0098793;neuron projection#GO:0043005;protein-containing complex#GO:0032991 ion channel#PC00133;voltage-gated ion channel#PC00241 HUMAN|HGNC=26607|UniProtKB=Q2M3R5 Q2M3R5 SLC35G1 PTHR22911:SF138 ACYL-MALONYL CONDENSING ENZYME-RELATED SOLUTE CARRIER FAMILY 35 MEMBER G1 calcium ion transmembrane transport#GO:0070588;intracellular monoatomic ion homeostasis#GO:0006873;regulation of cytosolic calcium ion concentration#GO:0051480;export from cell#GO:0140352;homeostatic process#GO:0042592;metal ion transport#GO:0030001;calcium ion homeostasis#GO:0055074;inorganic ion homeostasis#GO:0098771;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;transport#GO:0006810;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;establishment of localization#GO:0051234;calcium ion transport#GO:0006816;cellular homeostasis#GO:0019725;intracellular calcium ion homeostasis#GO:0006874;intracellular chemical homeostasis#GO:0055082 cell periphery#GO:0071944;membrane#GO:0016020;cytoplasm#GO:0005737;plasma membrane#GO:0005886;endomembrane system#GO:0012505;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227 transporter#PC00227 HUMAN|HGNC=3793|UniProtKB=P14207 P14207 FOLR2 PTHR10517:SF8 FOLATE RECEPTOR FOLATE RECEPTOR BETA cargo receptor activity#GO:0038024;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 dicarboxylic acid transport#GO:0006835;vitamin transport#GO:0051180;nitrogen compound transport#GO:0071705;establishment of localization#GO:0051234;localization#GO:0051179;organic acid transport#GO:0015849;carboxylic acid transport#GO:0046942;transport#GO:0006810 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=20844|UniProtKB=Q8NFN8 Q8NFN8 GPR156 PTHR10519:SF80 GABA-B RECEPTOR G PROTEIN-COUPLED RECEPTOR 156-RELATED transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930 biological regulation#GO:0065007;signaling#GO:0023052;cell-cell signaling#GO:0007267;cell communication#GO:0007154;cellular process#GO:0009987;regulation of biological process#GO:0050789 membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;signaling receptor complex#GO:0043235 G-protein coupled receptor#PC00021 HUMAN|HGNC=17938|UniProtKB=Q9NYX4 Q9NYX4 CALY PTHR28546:SF1 NEURONAL VESICLE TRAFFICKING-ASSOCIATED PROTEIN 2-RELATED NEURON-SPECIFIC VESICULAR PROTEIN CALCYON biological regulation#GO:0065007;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;macromolecule localization#GO:0033036;regulation of biological quality#GO:0065008;protein transport#GO:0015031;intracellular protein localization#GO:0008104;cellular localization#GO:0051641;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;localization#GO:0051179;transport#GO:0006810;regulation of postsynaptic membrane neurotransmitter receptor levels#GO:0099072;metabolic process#GO:0008152 synaptic membrane#GO:0097060;postsynaptic membrane#GO:0045211;cell junction#GO:0030054;cell periphery#GO:0071944;membrane#GO:0016020;postsynapse#GO:0098794;plasma membrane#GO:0005886;synapse#GO:0045202;glutamatergic synapse#GO:0098978;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590 HUMAN|HGNC=4573|UniProtKB=P42263 P42263 GRIA3 PTHR18966:SF151 IONOTROPIC GLUTAMATE RECEPTOR GLUTAMATE RECEPTOR 3 monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;signaling receptor activity#GO:0038023;amino acid transmembrane transporter activity#GO:0015171;neurotransmitter receptor activity#GO:0030594;transporter activity#GO:0005215;transmembrane signaling receptor activity#GO:0004888;gated channel activity#GO:0022836;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;dicarboxylic acid transmembrane transporter activity#GO:0005310;glutamate receptor activity#GO:0008066;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;transmembrane transporter activity#GO:0022857;molecular transducer activity#GO:0060089;channel activity#GO:0015267;carboxylic acid transmembrane transporter activity#GO:0046943;ligand-gated monoatomic ion channel activity#GO:0015276 regulation of trans-synaptic signaling#GO:0099177;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;synaptic transmission, glutamatergic#GO:0035249;synaptic signaling#GO:0099536;cellular process#GO:0009987;cell communication#GO:0007154;trans-synaptic signaling#GO:0099537;regulation of signaling#GO:0023051;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;modulation of chemical synaptic transmission#GO:0050804;signaling#GO:0023052;regulation of cell communication#GO:0010646;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789 cell projection#GO:0042995;neuron spine#GO:0044309;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;dendritic spine#GO:0043197;postsynapse#GO:0098794;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;protein-containing complex#GO:0032991;neuron projection#GO:0043005;cell junction#GO:0030054;transporter complex#GO:1990351;synaptic membrane#GO:0097060;plasma membrane bounded cell projection#GO:0120025;asymmetric synapse#GO:0032279;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;postsynaptic density membrane#GO:0098839;transmembrane transporter complex#GO:1902495;dendritic tree#GO:0097447;postsynaptic density#GO:0014069;dendrite#GO:0030425;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;monoatomic ion channel complex#GO:0034702;neuron to neuron synapse#GO:0098984;cell periphery#GO:0071944;membrane#GO:0016020;signaling receptor complex#GO:0043235 transmembrane signal receptor#PC00197 Ionotropic glutamate receptor pathway#P00037>AMPA#P01019;Metabotropic glutamate receptor group III pathway#P00039>A/K#P01046;Ionotropic glutamate receptor pathway#P00037>A/K#P01025;Ionotropic glutamate receptor pathway#P00037>Glu3#P01016 HUMAN|HGNC=28678|UniProtKB=Q8IVU9 Q8IVU9 CABCOCO1 PTHR28457:SF3 COILED-COIL DOMAIN-CONTAINING PROTEIN 189 CILIARY-ASSOCIATED CALCIUM-BINDING COILED-COIL PROTEIN 1 HUMAN|HGNC=6622|UniProtKB=P07098 P07098 LIPF PTHR11005:SF15 LYSOSOMAL ACID LIPASE-RELATED GASTRIC TRIACYLGLYCEROL LIPASE hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;lipase activity#GO:0016298;triacylglycerol lipase activity#GO:0004806 lipid metabolic process#GO:0006629;cellular process#GO:0009987;metabolic process#GO:0008152;primary metabolic process#GO:0044238 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 hydrolase#PC00121;lipase#PC00143 HUMAN|HGNC=29232|UniProtKB=Q460N5 Q460N5 PARP14 PTHR14453:SF89 PARP/ZINC FINGER CCCH TYPE DOMAIN CONTAINING PROTEIN PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP14 pentosyltransferase activity#GO:0016763;transcription regulator activity#GO:0140110;NAD+ poly-ADP-ribosyltransferase activity#GO:0003950;glycosyltransferase activity#GO:0016757;transcription coregulator activity#GO:0003712;transferase activity#GO:0016740;transcription corepressor activity#GO:0003714;catalytic activity#GO:0003824 negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of signal transduction#GO:0009966;negative regulation of immune system process#GO:0002683;negative regulation of response to stimulus#GO:0048585;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;regulation of response to stress#GO:0080134;regulation of gene expression#GO:0010468;regulation of innate immune response#GO:0045088;regulation of biosynthetic process#GO:0009889;negative regulation of response to cytokine stimulus#GO:0060761;regulation of response to biotic stimulus#GO:0002831;regulation of cell communication#GO:0010646;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;negative regulation of defense response#GO:0031348;regulation of immune response#GO:0050776;negative regulation of immune response#GO:0050777;regulation of defense response#GO:0031347;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of response to cytokine stimulus#GO:0060759;negative regulation of response to external stimulus#GO:0032102;negative regulation of innate immune response#GO:0045824;negative regulation of signal transduction#GO:0009968;regulation of response to external stimulus#GO:0032101;negative regulation of cytokine-mediated signaling pathway#GO:0001960;regulation of cytokine-mediated signaling pathway#GO:0001959;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;negative regulation of metabolic process#GO:0009892;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 HUMAN|HGNC=9655|UniProtKB=P26045 P26045 PTPN3 PTHR45706:SF5 TYROSINE-PROTEIN PHOSPHATASE TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 3 protein tyrosine phosphatase activity#GO:0004725;hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578 membrane#GO:0016020;cytoplasmic side of plasma membrane#GO:0009898;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cytoplasmic side of membrane#GO:0098562;side of membrane#GO:0098552;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195 HUMAN|HGNC=11532|UniProtKB=Q15573 Q15573 TAF1A PTHR32122:SF1 TATA BOX-BINDING PROTEIN ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT A TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT A General transcription by RNA polymerase I#P00022>TAF-IA#P00651;General transcription by RNA polymerase I#P00022>SL1 complex#P00653 HUMAN|HGNC=14411|UniProtKB=Q9BQT8 Q9BQT8 SLC25A21 PTHR46356:SF1 MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER secondary carrier transporter#PC00258;transporter#PC00227 HUMAN|HGNC=29992|UniProtKB=Q96GU1 Q96GU1 PAGE5 PTHR14047:SF37 P ANTIGEN FAMILY MEMBER 5-RELATED P ANTIGEN FAMILY MEMBER 5 HUMAN|HGNC=2732|UniProtKB=P30046 P30046 DDT PTHR11954:SF21 D-DOPACHROME DECARBOXYLASE D-DOPACHROME DECARBOXYLASE catalytic activity#GO:0003824;intramolecular oxidoreductase activity#GO:0016860;isomerase activity#GO:0016853 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 decarboxylase#PC00089;lyase#PC00144;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=28331|UniProtKB=Q8WW62 Q8WW62 TMED6 PTHR22811:SF45 TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN 6 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;cargo adaptor activity#GO:0140312 vesicle-mediated transport#GO:0016192;endomembrane system organization#GO:0010256;macromolecule localization#GO:0033036;organelle organization#GO:0006996;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;transport#GO:0006810;intracellular protein transport#GO:0006886;Golgi vesicle transport#GO:0048193;cellular component organization#GO:0016043;Golgi organization#GO:0007030;localization#GO:0051179;cellular localization#GO:0051641;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;protein transport#GO:0015031 endomembrane system#GO:0012505;cytoplasm#GO:0005737;Golgi apparatus#GO:0005794;endoplasmic reticulum#GO:0005783;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;endoplasmic reticulum-Golgi intermediate compartment#GO:0005793;vesicle#GO:0031982;COPII-coated ER to Golgi transport vesicle#GO:0030134;membrane-bounded organelle#GO:0043227;coated vesicle#GO:0030135;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 membrane traffic protein#PC00150;vesicle coat protein#PC00235 HUMAN|HGNC=10575|UniProtKB=P13521 P13521 SCG2 PTHR15119:SF0 SECRETOGRANIN II SECRETOGRANIN-2 signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;signaling receptor regulator activity#GO:0030545;cytokine activity#GO:0005125;receptor ligand activity#GO:0048018 anatomical structure development#GO:0048856;cell chemotaxis#GO:0060326;system development#GO:0048731;chemotaxis#GO:0006935;cell motility#GO:0048870;locomotion#GO:0040011;blood vessel development#GO:0001568;cellular response to stimulus#GO:0051716;tube morphogenesis#GO:0035239;leukocyte chemotaxis#GO:0030595;response to external stimulus#GO:0009605;myeloid leukocyte migration#GO:0097529;leukocyte migration#GO:0050900;developmental process#GO:0032502;cell migration#GO:0016477;multicellular organismal process#GO:0032501;tube development#GO:0035295;angiogenesis#GO:0001525;animal gross anatomical part developmental process#GO:0160108;cellular response to chemical stimulus#GO:0070887;immune system process#GO:0002376;circulatory system development#GO:0072359;response to stimulus#GO:0050896;granulocyte chemotaxis#GO:0071621;blood vessel morphogenesis#GO:0048514;anatomical structure morphogenesis#GO:0009653;multicellular organism development#GO:0007275;vasculature development#GO:0001944;anatomical structure formation involved in morphogenesis#GO:0048646;granulocyte migration#GO:0097530;taxis#GO:0042330;response to chemical#GO:0042221;cellular process#GO:0009987 extracellular region#GO:0005576;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141;secretory vesicle#GO:0099503;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 Gonadotropin-releasing hormone receptor pathway#P06664>Scg2#G06880 HUMAN|HGNC=6294|UniProtKB=P51787 P51787 KCNQ1 PTHR11537:SF274 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 1 potassium channel activity#GO:0005267;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;transporter activity#GO:0005215;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216 heart process#GO:0003015;action potential#GO:0001508;muscle system process#GO:0003012;actin-mediated cell contraction#GO:0070252;metal ion transport#GO:0030001;striated muscle contraction#GO:0006941;circulatory system process#GO:0003013;actin filament-based process#GO:0030029;cardiac muscle contraction#GO:0060048;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;actin filament-based movement#GO:0030048;cellular process#GO:0009987;multicellular organismal process#GO:0032501;blood circulation#GO:0008015;cardiac muscle cell action potential involved in contraction#GO:0086002;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;transport#GO:0006810;muscle contraction#GO:0006936;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;cardiac muscle cell contraction#GO:0086003;system process#GO:0003008;heart contraction#GO:0060047 transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;cation channel complex#GO:0034703;voltage-gated potassium channel complex#GO:0008076;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;plasma membrane#GO:0005886;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944 voltage-gated ion channel#PC00241;ion channel#PC00133 HUMAN|HGNC=19903|UniProtKB=Q9NQL2 Q9NQL2 RRAGD PTHR11259:SF5 RAS-RELATED GTP BINDING RAG/GTR YEAST RAS-RELATED GTP-BINDING PROTEIN D carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;guanyl nucleotide binding#GO:0019001;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;ion binding#GO:0043167;GTPase activity#GO:0003924;anion binding#GO:0043168;small molecule binding#GO:0036094;hydrolase activity#GO:0016787 regulation of metabolic process#GO:0019222;positive regulation of TORC1 signaling#GO:1904263;response to nutrient levels#GO:0031667;positive regulation of cellular process#GO:0048522;positive regulation of response to stimulus#GO:0048584;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;cellular response to starvation#GO:0009267;regulation of response to stimulus#GO:0048583;cellular response to nutrient levels#GO:0031669;positive regulation of intracellular signal transduction#GO:1902533;regulation of catabolic process#GO:0009894;regulation of TORC1 signaling#GO:1903432;negative regulation of autophagy#GO:0010507;response to starvation#GO:0042594;positive regulation of signal transduction#GO:0009967;cellular response to stimulus#GO:0051716;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;positive regulation of TOR signaling#GO:0032008;negative regulation of catabolic process#GO:0009895;response to stress#GO:0006950;cellular process#GO:0009987;regulation of TOR signaling#GO:0032006;positive regulation of biological process#GO:0048518;regulation of autophagy#GO:0010506;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;negative regulation of metabolic process#GO:0009892;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;cellular response to stress#GO:0033554;positive regulation of signaling#GO:0023056 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;vacuole#GO:0005773;nucleus#GO:0005634;lysosome#GO:0005764;lytic vacuole#GO:0000323;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 small GTPase#PC00208 HUMAN|HGNC=17825|UniProtKB=P53816 P53816 PLAAT3 PTHR13943:SF82 HRAS-LIKE SUPPRESSOR - RELATED PHOSPHOLIPASE A AND ACYLTRANSFERASE 3 lipase activity#GO:0016298;acyltransferase activity#GO:0016746;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity#GO:0016787;glycerophospholipase activity#GO:0004620;transferase activity#GO:0016740;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phospholipase activity#GO:0120569;A2-type glycerophospholipase activity#GO:0004623;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 animal organ development#GO:0048513;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;lipid metabolic process#GO:0006629;developmental process#GO:0032502;lens development in camera-type eye#GO:0002088;sensory organ development#GO:0007423;metabolic process#GO:0008152;multicellular organismal process#GO:0032501;tissue development#GO:0009888;epithelial cell differentiation#GO:0030855;epithelium development#GO:0060429;glycerophospholipid metabolic process#GO:0006650;cellular process#GO:0009987;sensory system development#GO:0048880;organophosphate metabolic process#GO:0019637;eye development#GO:0001654;system development#GO:0048731;anatomical structure development#GO:0048856;animal gross anatomical part developmental process#GO:0160108;camera-type eye development#GO:0043010;phospholipid metabolic process#GO:0006644;visual system development#GO:0150063;cell differentiation#GO:0030154;glycerolipid metabolic process#GO:0046486;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;acyltransferase#PC00042 HUMAN|HGNC=8809|UniProtKB=Q15118 Q15118 PDK1 PTHR11947:SF14 PYRUVATE DEHYDROGENASE KINASE [PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE ISOZYME 1, MITOCHONDRIAL transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 regulation of biosynthetic process#GO:0009889;regulation of lipid metabolic process#GO:0019216;regulation of carbohydrate metabolic process#GO:0006109;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=3776|UniProtKB=P51816 P51816 AFF2 PTHR10528:SF18 AF4/FMR2 FAMILY MEMBER AF4_FMR2 FAMILY MEMBER 2 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;macromolecule biosynthetic process#GO:0009059;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;biosynthetic process#GO:0009058;regulation of RNA splicing#GO:0043484;nucleobase-containing compound metabolic process#GO:0006139;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;system process#GO:0003008;regulation of gene expression#GO:0010468;regulation of biological process#GO:0050789;nucleic acid biosynthetic process#GO:0141187;nervous system process#GO:0050877;RNA metabolic process#GO:0016070;DNA-templated transcription elongation#GO:0006354;cellular process#GO:0009987;gene expression#GO:0010467;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;transcription elongation factor complex#GO:0008023;organelle lumen#GO:0043233;nuclear speck#GO:0016607;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;protein-containing complex#GO:0032991;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;nuclear body#GO:0016604;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HUMAN|HGNC=25522|UniProtKB=Q9BUR4 Q9BUR4 WRAP53 PTHR13211:SF1 TELOMERASE CAJAL BODY PROTEIN 1 TELOMERASE CAJAL BODY PROTEIN 1 nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 cellular component organization or biogenesis#GO:0071840;nucleus organization#GO:0006997;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;organelle lumen#GO:0043233;membraneless organelle#GO:0043228;nuclear body#GO:0016604;intracellular membraneless organelle#GO:0043232;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974 HUMAN|HGNC=2184|UniProtKB=P38432 P38432 COIL PTHR15197:SF0 COILIN P80 COILIN snRNA binding#GO:0017069;RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 ribonucleoprotein complex biogenesis#GO:0022613;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;spliceosomal snRNP assembly#GO:0000387;protein-containing complex assembly#GO:0065003;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;nucleic acid metabolic process#GO:0090304;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;protein-RNA complex assembly#GO:0022618;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular component assembly#GO:0022607;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;mRNA processing#GO:0006397;protein-containing complex organization#GO:0043933;protein-RNA complex organization#GO:0071826;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;ribonucleoprotein granule#GO:0035770;supramolecular complex#GO:0099080;nuclear body#GO:0016604;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228;organelle lumen#GO:0043233;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 DNA metabolism protein#PC00009 HUMAN|HGNC=6877|UniProtKB=P27361 P27361 MAPK3 PTHR24055:SF393 MITOGEN-ACTIVATED PROTEIN KINASE MITOGEN-ACTIVATED PROTEIN KINASE 3 kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 non-receptor serine/threonine protein kinase#PC00167 CCKR signaling map#P06959>MAPK3#P07119;CCKR signaling map#P06959>MAPK1/3#P07228;Ras Pathway#P04393>ERK#P04542;T cell activation#P00053>ERK#P01300;PDGF signaling pathway#P00047>ERK#P01143;Angiogenesis#P00005>MEK#P00225;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>ERK#P00889;Endothelin signaling pathway#P00019>ERK#P00566;Apoptosis signaling pathway#P00006>MAPK#P00269;Alzheimer disease-amyloid secretase pathway#P00003>MAPK#P00099;Parkinson disease#P00049>ERK#P01211;Interferon-gamma signaling pathway#P00035>Serine kinase#P00955;VEGF signaling pathway#P00056>Erk#P01407;Gonadotropin-releasing hormone receptor pathway#P06664>ERK1/2#P06786;EGF receptor signaling pathway#P00018>ERK1-2#P00543;Toll receptor signaling pathway#P00054>ERK1#P01358;Angiogenesis#P00005>Erk#P00203;FGF signaling pathway#P00021>ERK1-2#P00627;TGF-beta signaling pathway#P00052>p42/p44MAPKs#P01293;VEGF signaling pathway#P00056>MEK#P01402;B cell activation#P00010>ERK#P00371;Angiotensin II-stimulated signaling through G proteins and beta-arrestin#P05911>MAPK#P05937;Integrin signalling pathway#P00034>ERK#P00907;Interleukin signaling pathway#P00036>ERK#P00965;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>MAPK#P00835 HUMAN|HGNC=24521|UniProtKB=Q5GLZ8 Q5GLZ8 HERC4 PTHR45622:SF5 UBIQUITIN-PROTEIN LIGASE E3A-RELATED E3 UBIQUITIN-PROTEIN LIGASE HERC4-RELATED acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein modification by small protein conjugation or removal#GO:0070647;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;modification-dependent protein catabolic process#GO:0019941;protein modification by small protein conjugation#GO:0032446;protein modification process#GO:0036211;primary metabolic process#GO:0044238;catabolic process#GO:0009056;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=998|UniProtKB=P20749 P20749 BCL3 PTHR24118:SF51 POTE ANKYRIN DOMAIN B-CELL LYMPHOMA 3 PROTEIN transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714;transcription regulator activity#GO:0140110 regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of non-canonical NF-kappaB signal transduction#GO:1901222 intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 membrane traffic protein#PC00150 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>NFkappaB#P00859 HUMAN|HGNC=12287|UniProtKB=A0A075B6R0 A0A075B6R0 TRGV2 PTHR19256:SF70 T-CELL RECEPTOR GAMMA CHAIN T CELL RECEPTOR GAMMA VARIABLE 2 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=17497|UniProtKB=Q8WZA0 Q8WZA0 LZIC PTHR16505:SF8 PROTEIN LZIC PROTEIN LZIC HUMAN|HGNC=23914|UniProtKB=A6NDE4 A6NDE4 RBMY1B PTHR48034:SF17 TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED RNA-BINDING MOTIF PROTEIN, Y CHROMOSOME, FAMILY 1 MEMBER A1-RELATED nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;RNA binding#GO:0003723 RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;mRNA splicing, via spliceosome#GO:0000398;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397 intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226 RNA metabolism protein#PC00031 HUMAN|HGNC=1934|UniProtKB=Q5VXU3 Q5VXU3 CHIC1 PTHR13005:SF2 CYSTEINE-RICH HYDROPHOBIC DOMAIN PROTEIN BRAIN X-LINKED PROTEIN CYSTEINE-RICH HYDROPHOBIC DOMAIN-CONTAINING PROTEIN 1 membrane#GO:0016020;cellular anatomical structure#GO:0110165 HUMAN|HGNC=6207|UniProtKB=P14923 P14923 JUP PTHR45976:SF3 ARMADILLO SEGMENT POLARITY PROTEIN JUNCTION PLAKOGLOBIN cell adhesion molecule binding#GO:0050839;transcription factor binding#GO:0008134;nuclear receptor binding#GO:0016922;transcription coregulator activity#GO:0003712;protein phosphatase binding#GO:0019903;transcription coactivator activity#GO:0003713;transcription regulator activity#GO:0140110;enzyme binding#GO:0019899;phosphatase binding#GO:0019902;binding#GO:0005488;DNA-binding transcription factor binding#GO:0140297;RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629;protein binding#GO:0005515 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;Wnt signaling pathway#GO:0016055;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;canonical Wnt signaling pathway#GO:0060070;cell communication#GO:0007154;regulation of RNA metabolic process#GO:0051252;cell-cell adhesion#GO:0098609;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of transcription by RNA polymerase II#GO:0045944;cell surface receptor signaling pathway#GO:0007166;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;signaling#GO:0023052;cell adhesion#GO:0007155;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893 anchoring junction#GO:0070161;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;extrinsic component of plasma membrane#GO:0019897;extrinsic component of membrane#GO:0019898;cell junction#GO:0030054;adherens junction#GO:0005912;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;plasma membrane#GO:0005886;membrane#GO:0016020;cell-cell junction#GO:0005911;nucleus#GO:0005634;cell periphery#GO:0071944 Alzheimer disease-presenilin pathway#P00004>gammacatenin#P00153 HUMAN|HGNC=18039|UniProtKB=Q9UGL1 Q9UGL1 KDM5B PTHR10694:SF3 LYSINE-SPECIFIC DEMETHYLASE LYSINE-SPECIFIC DEMETHYLASE 5B catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;histone demethylase activity#GO:0032452;oxidoreductase activity#GO:0016491;demethylase activity#GO:0032451;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;catalytic activity, acting on a protein#GO:0140096;protein demethylase activity#GO:0140457;dioxygenase activity#GO:0051213;histone modifying activity#GO:0140993 regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;chromatin organization#GO:0006325;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;chromatin remodeling#GO:0006338;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226 histone modifying enzyme#PC00261 HUMAN|HGNC=2891|UniProtKB=O94907 O94907 DKK1 PTHR12113:SF11 DICKKOPF3-LIKE 3 DICKKOPF-RELATED PROTEIN 1 protein binding#GO:0005515;molecular function inhibitor activity#GO:0140678;molecular function regulator activity#GO:0098772;signaling receptor inhibitor activity#GO:0030547;signaling receptor regulator activity#GO:0030545;binding#GO:0005488 regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111;regulation of cellular process#GO:0050794;regulation of signaling#GO:0023051;negative regulation of canonical Wnt signaling pathway#GO:0090090;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648;regulation of canonical Wnt signaling pathway#GO:0060828;negative regulation of signal transduction#GO:0009968;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of Wnt signaling pathway#GO:0030178;negative regulation of response to stimulus#GO:0048585;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 membrane traffic protein#PC00150;membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=20149|UniProtKB=Q8N8N7 Q8N8N7 PTGR2 PTHR43205:SF5 PROSTAGLANDIN REDUCTASE PROSTAGLANDIN REDUCTASE 2 catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;oxidoreductase activity#GO:0016491 lipid metabolic process#GO:0006629;unsaturated fatty acid metabolic process#GO:0033559;prostaglandin metabolic process#GO:0006693;fatty acid metabolic process#GO:0006631;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;cellular process#GO:0009987;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;icosanoid metabolic process#GO:0006690;small molecule metabolic process#GO:0044281 reductase#PC00198 HUMAN|HGNC=14217|UniProtKB=Q9NY57 Q9NY57 STK32B PTHR24356:SF157 SERINE/THREONINE-PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE 32B phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=14245|UniProtKB=O95149 O95149 SNUPN PTHR13403:SF6 SNURPORTIN1 RNUT1 PROTEIN RNA, U TRANSPORTER 1 SNURPORTIN-1 transporter#PC00227 HUMAN|HGNC=20686|UniProtKB=Q8IV76 Q8IV76 PASD1 PTHR46055:SF5 CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT CIRCADIAN CLOCK PROTEIN PASD1 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;negative regulation of macromolecule metabolic process#GO:0010605;regulation of circadian rhythm#GO:0042752;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;circadian regulation of gene expression#GO:0032922;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;circadian rhythm#GO:0007623;rhythmic process#GO:0048511 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HUMAN|HGNC=15483|UniProtKB=Q8IVW4 Q8IVW4 CDKL3 PTHR24056:SF177 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE-LIKE 3 protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=26784|UniProtKB=Q9H3J6 Q9H3J6 MTRFR PTHR46203:SF1 PROBABLE PEPTIDE CHAIN RELEASE FACTOR C12ORF65 MITOCHONDRIAL TRANSLATION RELEASE FACTOR IN RESCUE intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 translation release factor#PC00225 HUMAN|HGNC=25723|UniProtKB=Q86V25 Q86V25 VASH2 PTHR15750:SF4 VASOHIBIN-1-LIKE ISOFORM X2 TUBULINYL-TYR CARBOXYPEPTIDASE 2 regulation of biological process#GO:0050789;regulation of multicellular organismal development#GO:2000026;regulation of developmental process#GO:0050793;biological regulation#GO:0065007;regulation of multicellular organismal process#GO:0051239;regulation of vasculature development#GO:1901342;regulation of anatomical structure morphogenesis#GO:0022603;regulation of angiogenesis#GO:0045765 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=17271|UniProtKB=P62070 P62070 RRAS2 PTHR24070:SF396 RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY RAS-RELATED PROTEIN R-RAS2 hydrolase activity#GO:0016787;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;Ras protein signal transduction#GO:0007265;establishment or maintenance of cell polarity#GO:0007163;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;small GTPase-mediated signal transduction#GO:0007264;intracellular signaling cassette#GO:0141124;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 small GTPase#PC00208 EGF receptor signaling pathway#P00018>Ras#P00552;TGF-beta signaling pathway#P00052>Ras-GDP#P01291;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Ras#P00869;TGF-beta signaling pathway#P00052>Ras-GTP#P01280 HUMAN|HGNC=13554|UniProtKB=Q8NB49 Q8NB49 ATP11C PTHR24092:SF38 PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE PHOSPHOLIPID-TRANSPORTING ATPASE IG ATPase-coupled intramembrane lipid carrier activity#GO:0140326;ATP-dependent activity#GO:0140657;transporter activity#GO:0005215;lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104;intramembrane lipid carrier activity#GO:0140303 localization#GO:0051179;regulation of biological quality#GO:0065008;lipid localization#GO:0010876;organophosphate ester transport#GO:0015748;lipid translocation#GO:0034204;cellular component organization#GO:0016043;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;regulation of membrane lipid distribution#GO:0097035;transport#GO:0006810;lipid transport#GO:0006869;biological regulation#GO:0065007;phospholipid translocation#GO:0045332;phospholipid transport#GO:0015914;membrane organization#GO:0061024;macromolecule localization#GO:0033036;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;cytoplasm#GO:0005737;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;recycling endosome#GO:0055037;endoplasmic reticulum#GO:0005783 transporter#PC00227;primary active transporter#PC00068 HUMAN|HGNC=9020|UniProtKB=P30613 P30613 PKLR PTHR11817:SF31 PYRUVATE KINASE PYRUVATE KINASE PKLR phosphotransferase activity, alcohol group as acceptor#GO:0016773;pyruvate kinase activity#GO:0004743;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772 pyruvate metabolic process#GO:0006090;response to stimulus#GO:0050896;cellular response to hormone stimulus#GO:0032870;purine nucleotide metabolic process#GO:0006163;pyridine-containing compound catabolic process#GO:0072526;purine-containing compound metabolic process#GO:0072521;monocarboxylic acid metabolic process#GO:0032787;nucleotide metabolic process#GO:0009117;carbohydrate catabolic process#GO:0016052;cellular response to chemical stimulus#GO:0070887;purine nucleoside diphosphate metabolic process#GO:0009135;ribonucleotide metabolic process#GO:0009259;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987;ribose phosphate metabolic process#GO:0019693;nucleobase-containing small molecule metabolic process#GO:0055086;purine nucleoside diphosphate catabolic process#GO:0009137;ADP catabolic process#GO:0046032;carbohydrate derivative catabolic process#GO:1901136;nucleoside triphosphate metabolic process#GO:0009141;nucleoside phosphate catabolic process#GO:1901292;cellular response to stimulus#GO:0051716;response to insulin#GO:0032868;purine nucleoside triphosphate metabolic process#GO:0009144;primary metabolic process#GO:0044238;aerobic respiration#GO:0009060;purine ribonucleoside diphosphate catabolic process#GO:0009181;pyridine-containing compound metabolic process#GO:0072524;nucleoside diphosphate metabolic process#GO:0009132;response to peptide hormone#GO:0043434;glycolytic process#GO:0006096;purine ribonucleoside triphosphate metabolic process#GO:0009205;organophosphate metabolic process#GO:0019637;ADP metabolic process#GO:0046031;generation of precursor metabolites and energy#GO:0006091;purine ribonucleoside diphosphate metabolic process#GO:0009179;cellular response to insulin stimulus#GO:0032869;pyridine nucleotide catabolic process#GO:0019364;small molecule metabolic process#GO:0044281;cellular response to endogenous stimulus#GO:0071495;ribonucleoside diphosphate metabolic process#GO:0009185;response to endogenous stimulus#GO:0009719;phosphorus metabolic process#GO:0006793;carboxylic acid metabolic process#GO:0019752;response to oxygen-containing compound#GO:1901700;oxoacid metabolic process#GO:0043436;response to chemical#GO:0042221;nicotinamide nucleotide metabolic process#GO:0046496;ATP metabolic process#GO:0046034;response to hormone#GO:0009725;purine-containing compound catabolic process#GO:0072523;metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;carbohydrate metabolic process#GO:0005975;nucleoside phosphate metabolic process#GO:0006753;cellular response to peptide hormone stimulus#GO:0071375;catabolic process#GO:0009056;purine ribonucleotide catabolic process#GO:0009154;nucleoside diphosphate catabolic process#GO:0009134;response to nitrogen compound#GO:1901698;ribonucleoside diphosphate catabolic process#GO:0009191;organophosphate catabolic process#GO:0046434;cellular respiration#GO:0045333;purine nucleotide catabolic process#GO:0006195;nucleobase-containing compound metabolic process#GO:0006139;cellular response to nitrogen compound#GO:1901699;carbohydrate derivative metabolic process#GO:1901135;ribonucleotide catabolic process#GO:0009261;nucleobase-containing compound catabolic process#GO:0034655;energy derivation by oxidation of organic compounds#GO:0015980;nucleotide catabolic process#GO:0009166 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 kinase#PC00137 Pyruvate metabolism#P02772>Pyruvate Kinase#P03132;Glycolysis#P00024>Pyruvate kinase#P00675 HUMAN|HGNC=17754|UniProtKB=Q9NS62 Q9NS62 THSD1 PTHR16311:SF3 THROMBOSPONDIN TYPE I DOMAIN-CONTAINING 1 THROMBOSPONDIN TYPE-1 DOMAIN-CONTAINING PROTEIN 1 cell periphery#GO:0071944;cellular anatomical structure#GO:0110165 HUMAN|HGNC=20763|UniProtKB=Q9P2R3 Q9P2R3 ANKFY1 PTHR24118:SF82 POTE ANKYRIN DOMAIN ANKYRIN REPEAT AND FYVE DOMAIN-CONTAINING PROTEIN 1 enzyme binding#GO:0019899;binding#GO:0005488;small GTPase binding#GO:0031267;protein binding#GO:0005515 establishment of localization in cell#GO:0051649;cellular process#GO:0009987;retrograde transport, endosome to Golgi#GO:0042147;vesicle-mediated transport#GO:0016192;vacuolar transport#GO:0007034;Golgi vesicle transport#GO:0048193;transport#GO:0006810;intracellular transport#GO:0046907;endosomal transport#GO:0016197;establishment of localization#GO:0051234;cytosolic transport#GO:0016482;lysosomal transport#GO:0007041;post-Golgi vesicle-mediated transport#GO:0006892;localization#GO:0051179;cellular localization#GO:0051641;Golgi to vacuole transport#GO:0006896 bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane#GO:0016020;vesicle membrane#GO:0012506;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;endosome membrane#GO:0010008;endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;vesicle#GO:0031982;retromer complex#GO:0030904;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 membrane traffic protein#PC00150 HUMAN|HGNC=7212|UniProtKB=Q96Q89 Q96Q89 KIF20B PTHR24115:SF534 KINESIN-RELATED KINESIN-LIKE PROTEIN KIF20B protein binding#GO:0005515;ATP-dependent activity#GO:0140657;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;cytoskeletal motor activity#GO:0003774;cytoskeletal protein binding#GO:0008092;hydrolase activity, acting on acid anhydrides#GO:0016817;microtubule motor activity#GO:0003777;ATP hydrolysis activity#GO:0016887;hydrolase activity#GO:0016787;polypeptide conformation or assembly isomerase activity#GO:0120544;microtubule binding#GO:0008017;ribonucleoside triphosphate phosphatase activity#GO:0017111;isomerase activity#GO:0016853;macromolecular conformation isomerase activity#GO:0120543;tubulin binding#GO:0015631;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462 cellular process#GO:0009987;microtubule-based movement#GO:0007018;microtubule-based process#GO:0007017 microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;nucleus#GO:0005634 microtubule or microtubule-binding cytoskeletal protein#PC00157;microtubule binding motor protein#PC00156 HUMAN|HGNC=9994|UniProtKB=O14924 O14924 RGS12 PTHR45945:SF1 REGULATOR OF G-PROTEIN SIGNALING LOCO REGULATOR OF G PROTEIN SIGNALING 12 enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme activator activity#GO:0008047 regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;regulation of G protein-coupled receptor signaling pathway#GO:0008277;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;nucleus#GO:0005634;cell periphery#GO:0071944;organelle#GO:0043226;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>RGS#P00704;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>RGS#P00731 HUMAN|HGNC=31797|UniProtKB=P0C7V6 P0C7V6 SUPT20HL2 PTHR13526:SF24 TRANSCRIPTION FACTOR SPT20 HOMOLOG TRANSCRIPTION FACTOR SPT20 HOMOLOG-LIKE 2 transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 intracellular membraneless organelle#GO:0043232;peptidase complex#GO:1905368;protein-containing complex#GO:0032991;chromatin#GO:0000785;SAGA complex#GO:0000124;intracellular protein-containing complex#GO:0140535;histone acetyltransferase complex#GO:0000123;membraneless organelle#GO:0043228;transferase complex#GO:1990234;cellular anatomical structure#GO:0110165;organelle#GO:0043226;chromosome#GO:0005694;intracellular anatomical structure#GO:0005622;acetyltransferase complex#GO:1902493;SAGA-type complex#GO:0070461;protein acetyltransferase complex#GO:0031248;intracellular organelle#GO:0043229;catalytic complex#GO:1902494 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=4738|UniProtKB=Q16777 Q16777 H2AC20 PTHR23430:SF130 HISTONE H2A HISTONE H2A TYPE 2-C structural molecule activity#GO:0005198 cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;heterochromatin formation#GO:0031507;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;regulation of metabolic process#GO:0019222;epigenetic regulation of gene expression#GO:0040029;regulation of macromolecule biosynthetic process#GO:0010556;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;cellular component assembly#GO:0022607;heterochromatin organization#GO:0070828;chromatin organization#GO:0006325;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;regulation of biosynthetic process#GO:0009889;negative regulation of gene expression, epigenetic#GO:0045814;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;chromosome#GO:0005694;chromatin#GO:0000785;nucleus#GO:0005634;protein-DNA complex#GO:0032993;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleosome#GO:0000786;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=29106|UniProtKB=O94830 O94830 DDHD2 PTHR23509:SF7 PA-PL1 PHOSPHOLIPASE FAMILY TRIACYLGLYCEROL HYDROLASE DDHD2 catalytic activity#GO:0003824;glycerophospholipase activity#GO:0004620;phospholipase activity#GO:0120569;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;lipase activity#GO:0016298;triacylglycerol lipase activity#GO:0004806;carboxylic ester hydrolase activity#GO:0052689 vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;coated vesicle#GO:0030135;intracellular anatomical structure#GO:0005622;COPII-coated ER to Golgi transport vesicle#GO:0030134 metabolite interconversion enzyme#PC00262;phospholipase#PC00186 HUMAN|HGNC=17134|UniProtKB=Q9BRT8 Q9BRT8 ZNG1A PTHR13748:SF31 COBW-RELATED ZINC-REGULATED GTPASE METALLOPROTEIN ACTIVATOR 1A-RELATED cation binding#GO:0043169;metal ion binding#GO:0046872;transition metal ion binding#GO:0046914;binding#GO:0005488;small molecule binding#GO:0036094;molecular carrier activity#GO:0140104;ion binding#GO:0043167;zinc ion binding#GO:0008270 metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=14987|UniProtKB=Q8TDY4 Q8TDY4 ASAP3 PTHR45854:SF1 ASAP FAMILY MEMBER ARF-GAP WITH SH3 DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 3 molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047 cell motility#GO:0048870;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component biogenesis#GO:0044087;regulation of stress fiber assembly#GO:0051492;regulation of actin filament bundle assembly#GO:0032231;regulation of organelle organization#GO:0033043;regulation of supramolecular fiber organization#GO:1902903;regulation of biological process#GO:0050789;regulation of actin filament-based process#GO:0032970;cell migration#GO:0016477;regulation of actin cytoskeleton organization#GO:0032956;biological regulation#GO:0065007;cellular process#GO:0009987;regulation of actin filament organization#GO:0110053 anchoring junction#GO:0070161;ruffle#GO:0001726;cell junction#GO:0030054;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;focal adhesion#GO:0005925;cell projection#GO:0042995;cell-substrate junction#GO:0030055;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;cell leading edge#GO:0031252 HUMAN|HGNC=20908|UniProtKB=Q86YF9 Q86YF9 DZIP1 PTHR21502:SF5 ZINC FINGER PROTEIN DZIP1 CILIUM ASSEMBLY PROTEIN DZIP1 protein sequestering activity#GO:0140311;molecular sequestering activity#GO:0140313;binding#GO:0005488;protein-containing complex binding#GO:0044877 organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031;cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component assembly#GO:0022607;cell projection organization#GO:0030030;plasma membrane bounded cell projection organization#GO:0120036 microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;ciliary basal body#GO:0036064;cilium#GO:0005929;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;microtubule cytoskeleton#GO:0015630;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737 cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=29043|UniProtKB=Q6XUX3 Q6XUX3 DSTYK PTHR46392:SF1 DUAL SERINE/THREONINE AND TYROSINE PROTEIN KINASE DUAL SERINE_THREONINE AND TYROSINE PROTEIN KINASE positive regulation of MAPK cascade#GO:0043410;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;response to fibroblast growth factor#GO:0071774;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cellular response to growth factor stimulus#GO:0090287;negative regulation of apoptotic process#GO:0043066;positive regulation of response to stimulus#GO:0048584;positive regulation of cellular process#GO:0048522;regulation of cell communication#GO:0010646;positive regulation of ERK1 and ERK2 cascade#GO:0070374;response to growth factor#GO:0070848;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;positive regulation of signal transduction#GO:0009967;regulation of MAPK cascade#GO:0043408;regulation of apoptotic process#GO:0042981;regulation of fibroblast growth factor receptor signaling pathway#GO:0040036;regulation of ERK1 and ERK2 cascade#GO:0070372;negative regulation of programmed cell death#GO:0043069;positive regulation of biological process#GO:0048518;cellular response to fibroblast growth factor stimulus#GO:0044344;cellular response to growth factor stimulus#GO:0071363;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;response to endogenous stimulus#GO:0009719 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=17409|UniProtKB=Q96SR6 Q96SR6 ZNF382 PTHR24404:SF22 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 382 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218 HUMAN|HGNC=27344|UniProtKB=A2RU14 A2RU14 TMEM218 PTHR31622:SF1 TRANSMEMBRANE PROTEIN 218 TRANSMEMBRANE PROTEIN 218 HUMAN|HGNC=11578|UniProtKB=Q86TI0 Q86TI0 TBC1D1 PTHR22957:SF204 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN TBC1 DOMAIN FAMILY MEMBER 1 enzyme regulator activity#GO:0030234;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme activator activity#GO:0008047 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 GTPase-activating protein#PC00257;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HUMAN|HGNC=3769|UniProtKB=Q01740 Q01740 FMO1 PTHR23023:SF154 DIMETHYLANILINE MONOOXYGENASE FLAVIN-CONTAINING MONOOXYGENASE 1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen#GO:0016709;monooxygenase activity#GO:0004497;oxidoreductase activity#GO:0016491 metabolic process#GO:0008152;sulfur compound metabolic process#GO:0006790;cellular process#GO:0009987;biosynthetic process#GO:0009058 oxygenase#PC00177;oxidoreductase#PC00176 HUMAN|HGNC=13291|UniProtKB=P60520 P60520 GABARAPL2 PTHR10969:SF114 MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED GAMMA-AMINOBUTYRIC ACID RECEPTOR-ASSOCIATED PROTEIN-LIKE 2 protein binding#GO:0005515;ubiquitin protein ligase binding#GO:0031625;lipid binding#GO:0008289;phospholipid binding#GO:0005543;ubiquitin-like protein ligase binding#GO:0044389;binding#GO:0005488;enzyme binding#GO:0019899 protein-containing complex disassembly#GO:0032984;catabolic process#GO:0009056;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular component organization#GO:0016043;response to starvation#GO:0042594;process utilizing autophagic mechanism#GO:0061919;vacuole organization#GO:0007033;cellular component disassembly#GO:0022411;cellular response to stress#GO:0033554;organelle assembly#GO:0070925;macroautophagy#GO:0016236;cellular component assembly#GO:0022607;autophagosome organization#GO:1905037;cellular process#GO:0009987;autophagy#GO:0006914;response to stress#GO:0006950;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;response to nutrient levels#GO:0031667;protein-containing complex organization#GO:0043933;autophagosome assembly#GO:0000045;mitophagy#GO:0000423;cellular component organization or biogenesis#GO:0071840;cellular response to nutrient levels#GO:0031669;autophagy of mitochondrion#GO:0000422;autophagosome maturation#GO:0097352;metabolic process#GO:0008152;cellular response to starvation#GO:0009267 membrane#GO:0016020;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vacuole#GO:0005773;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;autophagosome#GO:0005776;intracellular organelle#GO:0043229;vacuolar membrane#GO:0005774;membrane-bounded organelle#GO:0043227;bounding membrane of organelle#GO:0098588;autophagosome membrane#GO:0000421;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090 non-motor microtubule binding protein#PC00166;cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=4461|UniProtKB=Q13491 Q13491 GPM6B PTHR11683:SF10 MYELIN PROTEOLIPID NEURONAL MEMBRANE GLYCOPROTEIN M6-B structural molecule activity#GO:0005198 myelination#GO:0042552;neurogenesis#GO:0022008;gliogenesis#GO:0042063;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;developmental process#GO:0032502;neuron differentiation#GO:0030182;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;multicellular organismal process#GO:0032501;glial cell differentiation#GO:0010001;oligodendrocyte differentiation#GO:0048709;cellular process#GO:0009987;axon development#GO:0061564;neuron projection development#GO:0031175;neuron development#GO:0048666;system development#GO:0048731;anatomical structure development#GO:0048856;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;cell projection organization#GO:0030030;central nervous system development#GO:0007417;cell differentiation#GO:0030154;cellular component organization#GO:0016043 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;myelin sheath#GO:0043209 myelin protein#PC00161 HUMAN|HGNC=1358|UniProtKB=P02748 P02748 C9 PTHR45742:SF3 COMPLEMENT COMPONENT C6 COMPLEMENT COMPONENT C9 regulation of response to stimulus#GO:0048583;immune effector process#GO:0002252;positive regulation of immune response#GO:0050778;humoral immune response#GO:0006959;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;complement activation#GO:0006956;positive regulation of biological process#GO:0048518;immune response#GO:0006955;activation of immune response#GO:0002253;positive regulation of immune system process#GO:0002684;regulation of immune response#GO:0050776;immune system process#GO:0002376;regulation of immune system process#GO:0002682;response to stimulus#GO:0050896;regulation of biological process#GO:0050789 extracellular region#GO:0005576;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797 complement component#PC00078 HUMAN|HGNC=18861|UniProtKB=Q6PIU1 Q6PIU1 KCNV1 PTHR11537:SF38 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY V MEMBER 1 channel regulator activity#GO:0016247;molecular function regulator activity#GO:0098772;transporter regulator activity#GO:0141108;potassium channel regulator activity#GO:0015459;ion channel regulator activity#GO:0099106 transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;action potential#GO:0001508;metal ion transport#GO:0030001;transport#GO:0006810;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;cellular process#GO:0009987;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;potassium ion transmembrane transport#GO:0071805;biological regulation#GO:0065007;monoatomic cation transmembrane transport#GO:0098655 transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;cation channel complex#GO:0034703;voltage-gated potassium channel complex#GO:0008076;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944 ion channel#PC00133;voltage-gated ion channel#PC00241 HUMAN|HGNC=44206|UniProtKB=A6NC86 A6NC86 PINLYP PTHR20914:SF50 LY6/PLAUR DOMAIN-CONTAINING PROTEIN 8 PHOSPHOLIPASE A2 INHIBITOR AND LY6_PLAUR DOMAIN-CONTAINING PROTEIN scaffold/adaptor protein#PC00226 HUMAN|HGNC=17046|UniProtKB=Q969F2 Q969F2 NKD2 PTHR22611:SF1 PROTEIN NAKED CUTICLE PROTEIN NAKED CUTICLE HOMOLOG 2 regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cell communication#GO:0010646;negative regulation of signal transduction#GO:0009968;regulation of Wnt signaling pathway#GO:0030111;negative regulation of response to stimulus#GO:0048585;regulation of cellular process#GO:0050794;negative regulation of Wnt signaling pathway#GO:0030178;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;negative regulation of cellular process#GO:0048523;negative regulation of cell communication#GO:0010648 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 Wnt signaling pathway#P00057>Naked#P01427 HUMAN|HGNC=4441|UniProtKB=P55259 P55259 GP2 PTHR14002:SF16 ENDOGLIN/TGF-BETA RECEPTOR TYPE III PANCREATIC SECRETORY GRANULE MEMBRANE MAJOR GLYCOPROTEIN GP2 myeloid leukocyte migration#GO:0097529;immune system process#GO:0002376;leukocyte migration#GO:0050900;cell motility#GO:0048870;granulocyte migration#GO:0097530;cell migration#GO:0016477;neutrophil migration#GO:1990266;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;cell surface#GO:0009986;cell periphery#GO:0071944;membrane#GO:0016020;apical plasma membrane#GO:0016324;extracellular region#GO:0005576;apical part of cell#GO:0045177 transmembrane signal receptor#PC00197 HUMAN|HGNC=16258|UniProtKB=Q6GMV2 Q6GMV2 SMYD5 PTHR46402:SF2 SET AND MYND DOMAIN-CONTAINING PROTEIN 5 PROTEIN-LYSINE N-TRIMETHYLTRANSFERASE SMYD5 catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring one-carbon groups#GO:0016741;protein methyltransferase activity#GO:0008276;lysine N-methyltransferase activity#GO:0016278;histone modifying activity#GO:0140993;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;methyltransferase activity#GO:0008168;histone methyltransferase activity#GO:0042054;protein-lysine N-methyltransferase activity#GO:0016279;N-methyltransferase activity#GO:0008170 regulation of biosynthetic process#GO:0009889;negative regulation of gene expression, epigenetic#GO:0045814;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;chromatin organization#GO:0006325;negative regulation of biosynthetic process#GO:0009890;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;epigenetic regulation of gene expression#GO:0040029;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789 HUMAN|HGNC=2159|UniProtKB=P21554 P21554 CNR1 PTHR22750:SF47 G-PROTEIN COUPLED RECEPTOR CANNABINOID RECEPTOR 1 G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021 Endogenous cannabinoid signaling#P05730>CB1#P05743 HUMAN|HGNC=31709|UniProtKB=Q5H913 Q5H913 ARL13A PTHR46090:SF1 ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 13B ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 13A cilium organization#GO:0044782;cellular localization#GO:0051641;localization#GO:0051179;non-motile cilium assembly#GO:1905515;localization within membrane#GO:0051668;organelle assembly#GO:0070925;protein localization to cilium#GO:0061512;protein localization to organelle#GO:0033365;cell projection organization#GO:0030030;cilium assembly#GO:0060271;cellular component organization#GO:0016043;protein localization to membrane#GO:0072657;intracellular protein localization#GO:0008104;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection assembly#GO:0120031;protein localization to cell periphery#GO:1990778;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;macromolecule localization#GO:0033036 organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane region#GO:0098590;plasma membrane#GO:0005886;ciliary membrane#GO:0060170;cilium#GO:0005929;cell projection membrane#GO:0031253;membrane-bounded organelle#GO:0043227;non-motile cilium#GO:0097730;organelle#GO:0043226;motile cilium#GO:0031514;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025 HUMAN|Ensembl=ENSG00000273957.2|UniProtKB=A0ABB0MVF2 A0ABB0MVF2 PTHR15566:SF11 POM121-LIKE SUBFAMILY NOT NAMED HUMAN|HGNC=9973|UniProtKB=P40937 P40937 RFC5 PTHR11669:SF9 REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT REPLICATION FACTOR C SUBUNIT 5 catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;ATP-dependent activity#GO:0140657;catalytic activity, acting on DNA#GO:0140097;ATP-dependent activity, acting on DNA#GO:0008094 response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;response to stress#GO:0006950;DNA replication#GO:0006260;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;DNA-templated DNA replication#GO:0006261;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA damage response#GO:0006974;cellular response to stress#GO:0033554 replication fork#GO:0005657;nucleus#GO:0005634;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 DNA-directed DNA polymerase#PC00018 DNA replication#P00017>RFC#P00529 HUMAN|HGNC=6133|UniProtKB=O14498 O14498 ISLR PTHR24366:SF14 IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS IMMUNOGLOBULIN SUPERFAMILY CONTAINING LEUCINE-RICH REPEAT PROTEIN positive regulation of cell differentiation#GO:0045597;regulation of anatomical structure size#GO:0090066;regulation of axonogenesis#GO:0050770;positive regulation of cell growth#GO:0030307;regulation of anatomical structure morphogenesis#GO:0022603;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;regulation of neuron projection development#GO:0010975;positive regulation of biological process#GO:0048518;regulation of multicellular organismal process#GO:0051239;positive regulation of cell development#GO:0010720;regulation of cell growth#GO:0001558;positive regulation of cellular component organization#GO:0051130;positive regulation of growth#GO:0045927;regulation of biological quality#GO:0065008;regulation of cell size#GO:0008361;positive regulation of axonogenesis#GO:0050772;positive regulation of multicellular organismal process#GO:0051240;regulation of multicellular organismal development#GO:2000026;regulation of cellular component size#GO:0032535;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;positive regulation of nervous system development#GO:0051962;regulation of cellular component organization#GO:0051128;regulation of cell differentiation#GO:0045595;positive regulation of developmental process#GO:0051094;regulation of cell projection organization#GO:0031344;regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of cell development#GO:0060284;positive regulation of cellular process#GO:0048522;biological regulation#GO:0065007;positive regulation of cell projection organization#GO:0031346;regulation of nervous system development#GO:0051960;regulation of growth#GO:0040008;regulation of neurogenesis#GO:0050767;positive regulation of neurogenesis#GO:0050769;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794 immunoglobulin superfamily cell adhesion molecule#PC00125 HUMAN|HGNC=19750|UniProtKB=Q9ULT0 Q9ULT0 TTC7A PTHR23083:SF475 TETRATRICOPEPTIDE REPEAT PROTEIN, TPR TETRATRICOPEPTIDE REPEAT PROTEIN 7A intracellular protein localization#GO:0008104;glycerophospholipid biosynthetic process#GO:0046474;lipid metabolic process#GO:0006629;protein localization to cell periphery#GO:1990778;metabolic process#GO:0008152;biosynthetic process#GO:0009058;glycerophospholipid metabolic process#GO:0006650;lipid biosynthetic process#GO:0008610;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;organophosphate metabolic process#GO:0019637;macromolecule localization#GO:0033036;localization#GO:0051179;cellular localization#GO:0051641;organophosphate biosynthetic process#GO:0090407;localization within membrane#GO:0051668;phosphatidylinositol phosphate biosynthetic process#GO:0046854;phospholipid metabolic process#GO:0006644;glycerolipid metabolic process#GO:0046486;phospholipid biosynthetic process#GO:0008654;protein localization to membrane#GO:0072657;protein localization to plasma membrane#GO:0072659;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=19181|UniProtKB=Q15058 Q15058 KIF14 PTHR24115:SF546 KINESIN-RELATED KINESIN-LIKE PROTEIN KIF14 ribonucleoside triphosphate phosphatase activity#GO:0017111;isomerase activity#GO:0016853;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;tubulin binding#GO:0015631;macromolecular conformation isomerase activity#GO:0120543;hydrolase activity#GO:0016787;microtubule motor activity#GO:0003777;ATP hydrolysis activity#GO:0016887;polypeptide conformation or assembly isomerase activity#GO:0120544;microtubule binding#GO:0008017;cytoskeletal motor activity#GO:0003774;hydrolase activity, acting on acid anhydrides#GO:0016817;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;ATP-dependent activity#GO:0140657 central nervous system development#GO:0007417;microtubule-based movement#GO:0007018;establishment of organelle localization#GO:0051656;forebrain development#GO:0030900;organelle localization#GO:0051640;animal gross anatomical part developmental process#GO:0160108;microtubule-based transport#GO:0099111;localization#GO:0051179;cellular localization#GO:0051641;anatomical structure development#GO:0048856;system development#GO:0048731;establishment of localization in cell#GO:0051649;vesicle localization#GO:0051648;cellular process#GO:0009987;brain development#GO:0007420;multicellular organismal process#GO:0032501;cytoskeleton-dependent intracellular transport#GO:0030705;establishment of vesicle localization#GO:0051650;head development#GO:0060322;organelle transport along microtubule#GO:0072384;nervous system development#GO:0007399;intracellular transport#GO:0046907;vesicle transport along microtubule#GO:0047496;developmental process#GO:0032502;transport#GO:0006810;multicellular organism development#GO:0007275;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;animal organ development#GO:0048513;vesicle cytoskeletal trafficking#GO:0099518;microtubule-based process#GO:0007017 organelle#GO:0043226;cellular anatomical structure#GO:0110165;microtubule#GO:0005874;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856 microtubule or microtubule-binding cytoskeletal protein#PC00157;microtubule binding motor protein#PC00156 HUMAN|HGNC=24973|UniProtKB=Q5SSJ5 Q5SSJ5 HP1BP3 PTHR15832:SF1 SHC (SRC HOMOLOGY DOMAIN C-TERMINAL) ADAPTOR HOMOLOG HETEROCHROMATIN PROTEIN 1-BINDING PROTEIN 3 chromatin binding#GO:0003682;binding#GO:0005488;nucleic acid binding#GO:0003676;nucleosome binding#GO:0031491;protein-containing complex binding#GO:0044877;DNA binding#GO:0003677 chromatin organization#GO:0006325;heterochromatin organization#GO:0070828;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043 intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;chromosome#GO:0005694;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232 scaffold/adaptor protein#PC00226 HUMAN|HGNC=24703|UniProtKB=Q3YEC7 Q3YEC7 RABL6 PTHR14932:SF1 RAS GTPASE-RELATED RAB-LIKE PROTEIN 6 heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;nucleotide binding#GO:0000166;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;binding#GO:0005488;small molecule binding#GO:0036094;anion binding#GO:0043168;ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265;guanyl nucleotide binding#GO:0019001 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cytosol#GO:0005829;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 small GTPase#PC00208 HUMAN|Ensembl=ENSG00000300293.2|UniProtKB=A0ABJ7H351 A0ABJ7H351 PTHR11224:SF53 MAKORIN-RELATED E3 UBIQUITIN-PROTEIN LIGASE MAKORIN-4-RELATED ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 protein modification by small protein conjugation or removal#GO:0070647;metabolic process#GO:0008152;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;protein modification process#GO:0036211;primary metabolic process#GO:0044238;cellular process#GO:0009987;protein modification by small protein conjugation#GO:0032446;post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=11284|UniProtKB=P18405 P18405 SRD5A1 PTHR10556:SF57 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE 1 catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627 lipid metabolic process#GO:0006629;metabolic process#GO:0008152;regulation of biological quality#GO:0065008;steroid biosynthetic process#GO:0006694;cellular process#GO:0009987;regulation of hormone levels#GO:0010817;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;steroid metabolic process#GO:0008202;hormone biosynthetic process#GO:0042446;biological regulation#GO:0065007;lipid biosynthetic process#GO:0008610;hormone metabolic process#GO:0042445 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=3224|UniProtKB=P52798 P52798 EFNA4 PTHR11304:SF42 EPHRIN EPHRIN-A4 signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515 axon development#GO:0061564;axon guidance#GO:0007411;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;cellular developmental process#GO:0048869;neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;ephrin receptor signaling pathway#GO:0048013;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;system development#GO:0048731;neuron projection development#GO:0031175;signal transduction#GO:0007165;cellular process#GO:0009987;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell surface receptor signaling pathway#GO:0007166;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cell projection morphogenesis#GO:0048858;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cell projection organization#GO:0030030;cell differentiation#GO:0030154;response to stimulus#GO:0050896;cell morphogenesis#GO:0000902;signaling#GO:0023052;cell development#GO:0048468;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;neuron development#GO:0048666;axonogenesis#GO:0007409 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 membrane-bound signaling molecule#PC00152;intercellular signal molecule#PC00207 HUMAN|HGNC=7028|UniProtKB=Q5EB52 Q5EB52 MEST PTHR43139:SF43 SI:DKEY-122A22.2 MESODERM-SPECIFIC TRANSCRIPT HOMOLOG PROTEIN serine protease#PC00203;protein modifying enzyme#PC00260 HUMAN|HGNC=1348|UniProtKB=Q5K651 Q5K651 SAMD9 PTHR16155:SF17 DED DOMAIN-CONTAINING PROTEIN STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 9 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=11802|UniProtKB=P31483 P31483 TIA1 PTHR10352:SF10 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G CYTOTOXIC GRANULE ASSOCIATED RNA BINDING PROTEIN TIA1 regulation of RNA metabolic process#GO:0051252;regulation of alternative mRNA splicing, via spliceosome#GO:0000381;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of mRNA metabolic process#GO:1903311;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of mRNA processing#GO:0050684;regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904 translational protein#PC00263;translation initiation factor#PC00224;translation factor#PC00223 HUMAN|HGNC=1536|UniProtKB=O43439 O43439 CBFA2T2 PTHR10379:SF13 MTG8 ETO EIGHT TWENTY ONE PROTEIN PROTEIN CBFA2T2 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714 regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HUMAN|HGNC=34393|UniProtKB=A3QJZ6 A3QJZ6 PRAMEF22 PTHR14224:SF79 SIMILAR TO PREFERENTIALLY EXPRESSED ANTIGEN IN MELANOMA-LIKE 3 PRAME FAMILY MEMBER 18-RELATED ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;cullin-RING ubiquitin ligase complex#GO:0031461;Cul2-RING ubiquitin ligase complex#GO:0031462;catalytic complex#GO:1902494;transferase complex#GO:1990234;ubiquitin ligase complex#GO:0000151;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535 HUMAN|HGNC=6847|UniProtKB=O14733 O14733 MAP2K7 PTHR48013:SF17 DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 7 protein kinase activity#GO:0004672;catalytic activity, acting on a protein#GO:0140096;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;response to stress#GO:0006950;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;stress-activated MAPK cascade#GO:0051403;cellular response to stress#GO:0033554;intracellular signal transduction#GO:0035556;MAPK cascade#GO:0000165;cell communication#GO:0007154 non-receptor serine/threonine protein kinase#PC00167 Huntington disease#P00029>MAPKK7#P00784;Apoptosis signaling pathway#P00006>MKK7#P00312;FGF signaling pathway#P00021>MKK4,7#P00637;EGF receptor signaling pathway#P00018>MKK4,7#P00555;Ras Pathway#P04393>MKK4/7#P04565;Gonadotropin-releasing hormone receptor pathway#P06664>MKK4/7#P06760 HUMAN|HGNC=20673|UniProtKB=P60153 P60153 RNASE9 PTHR11437:SF14 RIBONUCLEASE INACTIVE RIBONUCLEASE-LIKE PROTEIN 9 RNA nuclease activity#GO:0004540;nuclease activity#GO:0004518;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to other organism#GO:0051707;response to stimulus#GO:0050896;defense response to Gram-positive bacterium#GO:0050830;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;response to external stimulus#GO:0009605;defense response#GO:0006952;defense response to bacterium#GO:0042742;response to bacterium#GO:0009617 endoribonuclease#PC00094;RNA metabolism protein#PC00031 HUMAN|HGNC=7421|UniProtKB=P00403 P00403 MT-CO2 PTHR22888:SF9 CYTOCHROME C OXIDASE, SUBUNIT II CYTOCHROME C OXIDASE SUBUNIT 2 monoatomic cation transmembrane transporter activity#GO:0008324;electron transfer activity#GO:0009055;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;catalytic activity#GO:0003824;proton transmembrane transporter activity#GO:0015078;primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804;monoatomic ion transmembrane transporter activity#GO:0015075;oxidoreductase activity#GO:0016491 electron transport chain#GO:0022900;cellular process#GO:0009987;respiratory electron transport chain#GO:0022904;metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091;ATP synthesis coupled electron transport#GO:0042773;oxidative phosphorylation#GO:0006119;cellular respiration#GO:0045333;energy derivation by oxidation of organic compounds#GO:0015980;aerobic respiration#GO:0009060 transporter complex#GO:1990351;organelle membrane#GO:0031090;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;oxidoreductase complex#GO:1990204;membrane#GO:0016020;mitochondrial membrane#GO:0031966;respiratory chain complex#GO:0098803;mitochondrial envelope#GO:0005740;transmembrane transporter complex#GO:1902495;respiratory chain complex IV#GO:0045277;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;membrane protein complex#GO:0098796;cytochrome complex#GO:0070069;mitochondrion#GO:0005739 oxidoreductase#PC00176 Gonadotropin-releasing hormone receptor pathway#P06664>COX2#G06899;Gonadotropin-releasing hormone receptor pathway#P06664>COX2#G06686;Gonadotropin-releasing hormone receptor pathway#P06664>COX2#P06734 HUMAN|HGNC=7895|UniProtKB=Q99743 Q99743 NPAS2 PTHR46055:SF1 CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT NEURONAL PAS DOMAIN-CONTAINING PROTEIN 2 RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 circadian regulation of gene expression#GO:0032922;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;rhythmic process#GO:0048511;regulation of DNA-templated transcription#GO:0006355;circadian rhythm#GO:0007623;regulation of RNA metabolic process#GO:0051252;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634 HUMAN|HGNC=12722|UniProtKB=P62760 P62760 VSNL1 PTHR23055:SF101 CALCIUM BINDING PROTEINS VISININ-LIKE PROTEIN 1 cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 calmodulin-related#PC00061 HUMAN|HGNC=16661|UniProtKB=Q8IZU2 Q8IZU2 WDR17 PTHR44464:SF1 WD REPEAT-CONTAINING PROTEIN 17 WD REPEAT-CONTAINING PROTEIN 17 HUMAN|HGNC=9725|UniProtKB=P06737 P06737 PYGL PTHR11468:SF3 GLYCOGEN PHOSPHORYLASE GLYCOGEN PHOSPHORYLASE, LIVER FORM hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;catalytic activity#GO:0003824;glycosyltransferase activity#GO:0016757 carbohydrate metabolic process#GO:0005975;glucan catabolic process#GO:0009251;catabolic process#GO:0009056;polysaccharide metabolic process#GO:0005976;polysaccharide catabolic process#GO:0000272;glycogen metabolic process#GO:0005977;glucan metabolic process#GO:0044042;primary metabolic process#GO:0044238;carbohydrate catabolic process#GO:0016052;energy reserve metabolic process#GO:0006112;cellular process#GO:0009987;glycogen catabolic process#GO:0005980;macromolecule metabolic process#GO:0043170;energy derivation by oxidation of organic compounds#GO:0015980;generation of precursor metabolites and energy#GO:0006091;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 glycosyltransferase#PC00111;transferase#PC00220 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Phosphorylase a#P00718;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Phosphorylase b#P00717 HUMAN|HGNC=11728|UniProtKB=P54274 P54274 TERF1 PTHR46734:SF3 TELOMERIC REPEAT-BINDING FACTOR 1 TERF1 TELOMERIC REPEAT-BINDING FACTOR 1 catalytic activity, acting on DNA#GO:0140097;DNA polymerase activity#GO:0034061;telomerase activity#GO:0003720;sequence-specific DNA binding#GO:0043565;telomeric repeat DNA binding#GO:0042162;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;RNA-directed DNA polymerase activity#GO:0003964;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;binding#GO:0005488;nucleic acid binding#GO:0003676 negative regulation of metabolic process#GO:0009892;regulation of cellular component organization#GO:0051128;regulation of biological process#GO:0050789;regulation of DNA metabolic process#GO:0051052;regulation of organelle organization#GO:0033043;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;nucleic acid biosynthetic process#GO:0141187;telomere maintenance via telomere lengthening#GO:0010833;telomere maintenance via telomerase#GO:0007004;DNA biosynthetic process#GO:0071897;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;DNA metabolic process#GO:0006259;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of cellular component organization#GO:0051129;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;negative regulation of organelle organization#GO:0010639;telomere organization#GO:0032200;negative regulation of chromosome organization#GO:2001251;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;biosynthetic process#GO:0009058;negative regulation of DNA metabolic process#GO:0051053;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;macromolecule biosynthetic process#GO:0009059;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;telomere maintenance#GO:0000723;chromosome organization#GO:0051276;regulation of telomere maintenance#GO:0032204;macromolecule metabolic process#GO:0043170;RNA-templated DNA biosynthetic process#GO:0006278;negative regulation of cellular process#GO:0048523;regulation of chromosome organization#GO:0033044 chromosome#GO:0005694;organelle#GO:0043226;protein-DNA complex#GO:0032993;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nuclear telomere cap complex#GO:0000783;membrane-bounded organelle#GO:0043227;chromosome, telomeric repeat region#GO:0140445;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;chromosome, telomeric region#GO:0000781;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228 HUMAN|HGNC=31993|UniProtKB=Q86T75 Q86T75 NBPF11 PTHR14199:SF35 NEUROBLASTOMA BREAKPOINT FAMILY MEMBER 6-LIKE PROTEIN NBPF FAMILY MEMBER NBPF1-RELATED HUMAN|HGNC=23057|UniProtKB=Q8WUW1 Q8WUW1 BRK1 PTHR33668:SF3 PROTEIN BRICK1 PROTEIN BRICK1 structural molecule activity#GO:0005198;protein complex scaffold activity#GO:0140378 regulation of cellular component biogenesis#GO:0044087;regulation of plasma membrane bounded cell projection assembly#GO:0120032;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794;cell motility#GO:0048870;regulation of supramolecular fiber organization#GO:1902903;regulation of cellular component size#GO:0032535;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;cellular component organization#GO:0016043;regulation of biological quality#GO:0065008;regulation of cell projection assembly#GO:0060491;regulation of actin filament length#GO:0030832;positive regulation of cellular component organization#GO:0051130;positive regulation of cell projection organization#GO:0031346;biological regulation#GO:0065007;regulation of actin polymerization or depolymerization#GO:0008064;regulation of actin cytoskeleton organization#GO:0032956;positive regulation of cellular component biogenesis#GO:0044089;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;regulation of actin filament organization#GO:0110053;regulation of plasma membrane bounded cell projection organization#GO:0120035;cellular component organization or biogenesis#GO:0071840;regulation of actin nucleation#GO:0051125;regulation of anatomical structure size#GO:0090066;regulation of cell projection organization#GO:0031344;regulation of actin filament-based process#GO:0032970 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 HUMAN|HGNC=2022|UniProtKB=P51793 P51793 CLCN4 PTHR45711:SF2 CHLORIDE CHANNEL PROTEIN H(+)_CL(-) EXCHANGE TRANSPORTER 4 channel activity#GO:0015267;monoatomic anion channel activity#GO:0005253;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic anion transmembrane transporter activity#GO:0008509;chloride transmembrane transporter activity#GO:0015108;passive transmembrane transporter activity#GO:0022803;chloride channel activity#GO:0005254 transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;chloride transmembrane transport#GO:1902476;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698;chloride transport#GO:0006821;transport#GO:0006810;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220;monoatomic anion transport#GO:0006820;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;lytic vacuole membrane#GO:0098852;lysosome#GO:0005764;vesicle#GO:0031982;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endosome membrane#GO:0010008;endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;cytoplasm#GO:0005737;plasma membrane#GO:0005886;vacuole#GO:0005773;membrane#GO:0016020;vesicle membrane#GO:0012506;lysosomal membrane#GO:0005765;cell periphery#GO:0071944;vacuolar membrane#GO:0005774;lytic vacuole#GO:0000323;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090 transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=19659|UniProtKB=Q495N2 Q495N2 SLC36A3 PTHR22950:SF258 AMINO ACID TRANSPORTER PROTON-COUPLED AMINO ACID TRANSPORTER 3 L-amino acid transmembrane transporter activity#GO:0015179;active transmembrane transporter activity#GO:0022804;glycine transmembrane transporter activity#GO:0015187;solute:monoatomic cation symporter activity#GO:0015294;monoatomic ion transmembrane transporter activity#GO:0015075;neutral L-amino acid transmembrane transporter activity#GO:0015175;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;proton transmembrane transporter activity#GO:0015078;amino acid transmembrane transporter activity#GO:0015171;monoatomic cation transmembrane transporter activity#GO:0008324;symporter activity#GO:0015293;carboxylic acid transmembrane transporter activity#GO:0046943;solute:proton symporter activity#GO:0015295 proton transmembrane transport#GO:1902600;establishment of localization#GO:0051234;alanine transport#GO:0032328;transport#GO:0006810;carboxylic acid transport#GO:0046942;organic acid transport#GO:0015849;amino acid transport#GO:0006865;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987;L-amino acid transport#GO:0015807;nitrogen compound transport#GO:0071705;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;amino acid transmembrane transport#GO:0003333;neutral amino acid transport#GO:0015804;glycine transport#GO:0015816;carboxylic acid transmembrane transport#GO:1905039 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane-bounded organelle#GO:0043227;vacuolar membrane#GO:0005774;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;vacuole#GO:0005773;cellular anatomical structure#GO:0110165;organelle#GO:0043226 secondary carrier transporter#PC00258;amino acid transporter#PC00046 HUMAN|HGNC=7886|UniProtKB=P51513 P51513 NOVA1 PTHR10288:SF229 KH DOMAIN CONTAINING RNA BINDING PROTEIN RNA-BINDING PROTEIN NOVA-1 mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;RNA biosynthetic process#GO:0032774;RNA splicing, via transesterification reactions#GO:0000375;anatomical structure development#GO:0048856;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;macromolecule biosynthetic process#GO:0009059;multicellular organismal process#GO:0032501;regulation of mRNA processing#GO:0050684;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;regulation of RNA splicing#GO:0043484;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulation of gene expression#GO:0010468;regulation of biological process#GO:0050789;mRNA splicing, via spliceosome#GO:0000398;mRNA metabolic process#GO:0016071;animal gross anatomical part developmental process#GO:0160108;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;regulation of alternative mRNA splicing, via spliceosome#GO:0000381;mRNA processing#GO:0006397;cellular process#GO:0009987;gene expression#GO:0010467;nervous system development#GO:0007399;RNA processing#GO:0006396;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;regulation of mRNA metabolic process#GO:1903311;multicellular organism development#GO:0007275 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031 HUMAN|HGNC=17267|UniProtKB=Q8IZP6 Q8IZP6 RNF113B PTHR12930:SF1 ZINC FINGER PROTEIN 183 RING FINGER PROTEIN 113B catalytic activity, acting on a protein#GO:0140096;ubiquitin-protein transferase activity#GO:0004842;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular membrane-bounded organelle#GO:0043231;U2-type spliceosomal complex#GO:0005684;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;spliceosomal complex#GO:0005681 RNA processing factor#PC00147;RNA metabolism protein#PC00031;RNA splicing factor#PC00148 HUMAN|HGNC=5931|UniProtKB=A0A075B6I0 A0A075B6I0 IGLV8-61 PTHR23267:SF176 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN LAMBDA VARIABLE 8-61 response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=25308|UniProtKB=Q9H0C3 Q9H0C3 TMEM117 PTHR31226:SF1 TRANSMEMBRANE PROTEIN 117 TRANSMEMBRANE PROTEIN 117 signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress#GO:0070059;regulation of biological process#GO:0050789;cell death#GO:0008219;cellular response to stimulus#GO:0051716;apoptotic process#GO:0006915;programmed cell death#GO:0012501;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;intrinsic apoptotic signaling pathway#GO:0097193;cellular response to stress#GO:0033554;response to endoplasmic reticulum stress#GO:0034976;biological regulation#GO:0065007;signal transduction#GO:0007165;cellular process#GO:0009987;response to stress#GO:0006950;apoptotic signaling pathway#GO:0097190 HUMAN|HGNC=24628|UniProtKB=Q9H204 Q9H204 MED28 PTHR13512:SF2 MEDIATOR COMPLEX SUBUNIT 28 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 28 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mediator complex#GO:0016592;nuclear protein-containing complex#GO:0140513 RNA metabolism protein#PC00031;general transcription factor#PC00259 HUMAN|HGNC=10599|UniProtKB=P37088 P37088 SCNN1A PTHR11690:SF124 AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED EPITHELIAL SODIUM CHANNEL SUBUNIT ALPHA ligand-gated monoatomic ion channel activity#GO:0015276;gated channel activity#GO:0022836;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;transmembrane transporter activity#GO:0022857;sodium channel activity#GO:0005272;transporter activity#GO:0005215;ligand-gated monoatomic cation channel activity#GO:0099094;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic cation channel activity#GO:0005261;sodium ion transmembrane transporter activity#GO:0015081;metal ion transmembrane transporter activity#GO:0046873 transport#GO:0006810;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;cellular process#GO:0009987;sodium ion transport#GO:0006814;sodium ion transmembrane transport#GO:0035725;monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655 membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cation channel complex#GO:0034703;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;sodium channel complex#GO:0034706 transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=20717|UniProtKB=Q6P597 Q6P597 KLC3 PTHR45783:SF1 KINESIN LIGHT CHAIN KINESIN LIGHT CHAIN 3 binding#GO:0005488;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515 cellular process#GO:0009987;microtubule-based process#GO:0007017;microtubule-based movement#GO:0007018 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 microtubule binding motor protein#PC00156 Alzheimer disease-amyloid secretase pathway#P00003>kinesin#P00107 HUMAN|HGNC=18732|UniProtKB=Q9P2J3 Q9P2J3 KLHL9 PTHR45632:SF31 LD33804P KELCH-LIKE PROTEIN 9 ubiquitin-like ligase-substrate adaptor activity#GO:1990756;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;enzyme-substrate adaptor activity#GO:0140767 protein metabolic process#GO:0019538;regulation of cytokinesis#GO:0032465;regulation of cell division#GO:0051302;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of cell cycle#GO:0051726;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;regulation of biological process#GO:0050789;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;proteasomal protein catabolic process#GO:0010498;regulation of cell cycle process#GO:0010564;biological regulation#GO:0065007;cellular process#GO:0009987 midbody#GO:0030496;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cullin-RING ubiquitin ligase complex#GO:0031461;catalytic complex#GO:1902494;transferase complex#GO:1990234;ubiquitin ligase complex#GO:0000151;Cul3-RING ubiquitin ligase complex#GO:0031463;intracellular protein-containing complex#GO:0140535 scaffold/adaptor protein#PC00226 HUMAN|HGNC=20219|UniProtKB=Q6IN85 Q6IN85 PPP4R3A PTHR23318:SF3 ATP SYNTHASE GAMMA-RELATED SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 3A phosphatase activator activity#GO:0019211;protein phosphatase regulator activity#GO:0019888;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;phosphatase regulator activity#GO:0019208;enzyme activator activity#GO:0008047 regulation of DNA repair#GO:0006282;regulation of response to stimulus#GO:0048583;DNA damage response#GO:0006974;regulation of response to stress#GO:0080134;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;response to stress#GO:0006950;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of cellular response to stress#GO:0080135;regulation of double-strand break repair#GO:2000779;cellular response to stress#GO:0033554;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;cellular response to stimulus#GO:0051716;regulation of DNA metabolic process#GO:0051052;regulation of biological process#GO:0050789 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;protein serine/threonine phosphatase complex#GO:0008287;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;protein-containing complex#GO:0032991;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634 ATP synthase#PC00002 HUMAN|HGNC=17013|UniProtKB=O95971 O95971 CD160 PTHR15425:SF0 CD160 ANTIGEN CD160 ANTIGEN plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=10923|UniProtKB=P36021 P36021 SLC16A2 PTHR11360:SF123 MONOCARBOXYLATE TRANSPORTER MONOCARBOXYLATE TRANSPORTER 8 monocarboxylic acid transmembrane transporter activity#GO:0008028;active transmembrane transporter activity#GO:0022804;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291 transport#GO:0006810;regulation of hormone levels#GO:0010817;hormone transport#GO:0009914;localization#GO:0051179;establishment of localization#GO:0051234;biological regulation#GO:0065007;regulation of biological quality#GO:0065008 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227 HUMAN|HGNC=24113|UniProtKB=Q9H7F0 Q9H7F0 ATP13A3 PTHR45630:SF12 CATION-TRANSPORTING ATPASE-RELATED POLYAMINE-TRANSPORTING ATPASE 13A3 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;polyamine transmembrane transporter activity#GO:0015203 intracellular monoatomic ion homeostasis#GO:0006873;homeostatic process#GO:0042592;inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;localization#GO:0051179;transmembrane transport#GO:0055085;cellular process#GO:0009987;nitrogen compound transport#GO:0071705;monoatomic ion homeostasis#GO:0050801;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;transport#GO:0006810;chemical homeostasis#GO:0048878;intracellular calcium ion homeostasis#GO:0006874;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;establishment of localization#GO:0051234 membrane#GO:0016020;vesicle membrane#GO:0012506;endomembrane system#GO:0012505;late endosome#GO:0005770;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;late endosome membrane#GO:0031902;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;endosome membrane#GO:0010008;endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 primary active transporter#PC00068 HUMAN|Ensembl=ENSG00000274971.1|UniProtKB=A0A0G2JMM0 A0A0G2JMM0 LOC128966728 PTHR11738:SF168 MHC CLASS I NK CELL RECEPTOR IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN-RELATED transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;immune receptor activity#GO:0140375 cell communication#GO:0007154;regulation of immune response#GO:0050776;cell surface receptor signaling pathway#GO:0007166;regulation of response to stimulus#GO:0048583;immune response-regulating cell surface receptor signaling pathway#GO:0002768;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;signal transduction#GO:0007165;regulation of biological process#GO:0050789;immune response-regulating signaling pathway#GO:0002764;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=20290|UniProtKB=Q9H9S4 Q9H9S4 CAB39L PTHR10182:SF9 CALCIUM-BINDING PROTEIN 39-RELATED CALCIUM-BINDING PROTEIN 39-LIKE molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;kinase activator activity#GO:0019209;protein kinase regulator activity#GO:0019887;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;protein kinase activator activity#GO:0030295;protein serine/threonine kinase activator activity#GO:0043539;enzyme activator activity#GO:0008047 HUMAN|HGNC=28073|UniProtKB=Q8N6M9 Q8N6M9 ZFAND2A PTHR14677:SF11 ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED AN1-TYPE ZINC FINGER PROTEIN 2A cellular process#GO:0009987;establishment of protein localization#GO:0045184;proteasomal protein catabolic process#GO:0010498;establishment of protein localization to endoplasmic reticulum#GO:0072599;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;protein targeting to ER#GO:0045047;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;macromolecule metabolic process#GO:0043170;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;protein targeting#GO:0006605;catabolic process#GO:0009056;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;localization#GO:0051179 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 RNA metabolism protein#PC00031 HUMAN|HGNC=11373|UniProtKB=P52823 P52823 STC1 PTHR11245:SF1 STANNIOCALCIN STANNIOCALCIN-1 intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;inorganic ion homeostasis#GO:0098771;chemical homeostasis#GO:0048878;calcium ion homeostasis#GO:0055074;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;monoatomic ion homeostasis#GO:0050801;intracellular monoatomic ion homeostasis#GO:0006873;homeostatic process#GO:0042592 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 peptide hormone#PC00179 HUMAN|HGNC=24639|UniProtKB=Q96N28 Q96N28 PRELID3A PTHR11158:SF23 MSF1/PX19 RELATED PRELI DOMAIN CONTAINING PROTEIN 3A transporter activity#GO:0005215;molecular carrier activity#GO:0140104;lipid carrier activity#GO:0005319;lipid transfer activity#GO:0120013;phospholipid transfer activity#GO:0120014 macromolecule localization#GO:0033036;phospholipid transport#GO:0015914;lipid transport#GO:0006869;organophosphate ester transport#GO:0015748;transport#GO:0006810;lipid localization#GO:0010876;localization#GO:0051179;establishment of localization#GO:0051234 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;organelle envelope#GO:0031967;mitochondrial envelope#GO:0005740;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;mitochondrial intermembrane space#GO:0005758;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 transfer/carrier protein#PC00219 HUMAN|HGNC=29144|UniProtKB=Q8NDI1 Q8NDI1 EHBP1 PTHR23167:SF43 CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED EH DOMAIN-BINDING PROTEIN 1 cellular component organization or biogenesis#GO:0071840;actin cytoskeleton organization#GO:0030036;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component organization#GO:0016043;actin filament-based process#GO:0030029;cellular process#GO:0009987 scaffold/adaptor protein#PC00226 HUMAN|HGNC=11262|UniProtKB=P35325 P35325 SPRR2B PTHR48553:SF4 SMALL PROLINE-RICH PROTEIN 2E SMALL PROLINE-RICH PROTEIN 2B HUMAN|HGNC=16168|UniProtKB=Q96MK2 Q96MK2 RIPOR3 PTHR15829:SF15 PROTEIN KINASE PKN/PRK1, EFFECTOR RIPOR FAMILY MEMBER 3 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=7786|UniProtKB=P08651 P08651 NFIC PTHR11492:SF2 NUCLEAR FACTOR I NUCLEAR FACTOR 1 C-TYPE transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 HUMAN|HGNC=9461|UniProtKB=P41219 P41219 PRPH PTHR45652:SF14 GLIAL FIBRILLARY ACIDIC PROTEIN PERIPHERIN structural molecule activity#GO:0005198;structural constituent of cytoskeleton#GO:0005200 cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;intermediate filament cytoskeleton organization#GO:0045104;intermediate filament organization#GO:0045109;intermediate filament-based process#GO:0045103;supramolecular fiber organization#GO:0097435;cellular component organization or biogenesis#GO:0071840 cytoskeleton#GO:0005856;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;intermediate filament#GO:0005882;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;axon#GO:0030424;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025 intermediate filament#PC00129;cytoskeletal protein#PC00085 HUMAN|HGNC=1060|UniProtKB=P32302 P32302 CXCR5 PTHR10489:SF618 CELL ADHESION MOLECULE C-X-C CHEMOKINE RECEPTOR TYPE 5 binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888;protein binding#GO:0005515;molecular transducer activity#GO:0060089;cytokine receptor activity#GO:0004896;immune receptor activity#GO:0140375;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;cytokine binding#GO:0019955 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of biological quality#GO:0065008;cell chemotaxis#GO:0060326;immune system process#GO:0002376;positive regulation of cytosolic calcium ion concentration#GO:0007204;cellular response to chemical stimulus#GO:0070887;chemotaxis#GO:0006935;regulation of cellular process#GO:0050794;cell motility#GO:0048870;response to stimulus#GO:0050896;locomotion#GO:0040011;signaling#GO:0023052;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;calcium-mediated signaling#GO:0019722;response to external stimulus#GO:0009605;cell migration#GO:0016477;taxis#GO:0042330;response to chemical#GO:0042221;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;cellular process#GO:0009987;immune response#GO:0006955;signal transduction#GO:0007165 plasma membrane#GO:0005886;cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020 cell adhesion molecule#PC00069 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CHKR#P00854 HUMAN|HGNC=396|UniProtKB=P13196 P13196 ALAS1 PTHR13693:SF50 CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE 5-AMINOLEVULINATE SYNTHASE, NON-SPECIFIC, MITOCHONDRIAL catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 pigment metabolic process#GO:0042440;primary metabolic process#GO:0044238;heme biosynthetic process#GO:0006783;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;tetrapyrrole biosynthetic process#GO:0033014;heme metabolic process#GO:0042168;biosynthetic process#GO:0009058;metabolic process#GO:0008152;tetrapyrrole metabolic process#GO:0033013;pigment biosynthetic process#GO:0046148;porphyrin-containing compound metabolic process#GO:0006778;macromolecule metabolic process#GO:0043170;porphyrin-containing compound biosynthetic process#GO:0006779;protein metabolic process#GO:0019538 mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 transaminase#PC00216 HUMAN|HGNC=15474|UniProtKB=Q9Y566 Q9Y566 SHANK1 PTHR24135:SF3 SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN 1 protein binding#GO:0005515;signaling adaptor activity#GO:0035591;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;signaling receptor complex adaptor activity#GO:0030159;binding#GO:0005488;signaling receptor binding#GO:0005102 cellular component organization or biogenesis#GO:0071840;system process#GO:0003008;cognition#GO:0050890;nervous system process#GO:0050877;synapse organization#GO:0050808;multicellular organismal process#GO:0032501;cell junction organization#GO:0034330;cellular component organization#GO:0016043;cellular process#GO:0009987 postsynaptic membrane#GO:0045211;dendrite#GO:0030425;dendritic tree#GO:0097447;postsynaptic density#GO:0014069;asymmetric synapse#GO:0032279;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;neuron spine#GO:0044309;postsynapse#GO:0098794;dendritic spine#GO:0043197;cell junction#GO:0030054;synaptic membrane#GO:0097060;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;neuron to neuron synapse#GO:0098984;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 Ionotropic glutamate receptor pathway#P00037>PSD95#P00999 HUMAN|HGNC=976|UniProtKB=P54687 P54687 BCAT1 PTHR11825:SF70 SUBGROUP IIII AMINOTRANSFERASE BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, CYTOSOLIC catalytic activity#GO:0003824;transferase activity#GO:0016740;transaminase activity#GO:0008483 oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;proteinogenic amino acid metabolic process#GO:0170039;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;amino acid metabolic process#GO:0006520;small molecule catabolic process#GO:0044282 mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 transferase#PC00220;transaminase#PC00216 Isoleucine biosynthesis#P02748>Branched chain amino acid aminotransferase#P02994;Valine biosynthesis#P02785>Branched chain amino acid aminotransferase#P03215;Alanine biosynthesis#P02724>Branched chain amino acid aminotransferase#P02815;Leucine biosynthesis#P02749>Branched chain amino acid aminotransferase#P03000 HUMAN|HGNC=15171|UniProtKB=Q8NGM1 Q8NGM1 OR4C15 PTHR48002:SF53 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 4C15 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=27972|UniProtKB=Q86YV6 Q86YV6 MYLK4 PTHR24347:SF379 SERINE/THREONINE-PROTEIN KINASE MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4 kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cell communication#GO:0007154 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=8743|UniProtKB=P29120 P29120 PCSK1 PTHR42884:SF39 PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED NEUROENDOCRINE CONVERTASE 1 catalytic activity#GO:0003824;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;serine-type peptidase activity#GO:0008236;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787 peptide hormone processing#GO:0016486;cellular process#GO:0009987;protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059;hormone metabolic process#GO:0042445;gene expression#GO:0010467;protein maturation#GO:0051604;biological regulation#GO:0065007;biosynthetic process#GO:0009058;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;regulation of hormone levels#GO:0010817;proteolysis#GO:0006508;signaling receptor ligand precursor processing#GO:0140448;protein metabolic process#GO:0019538;regulation of biological quality#GO:0065008 Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;neuron projection#GO:0043005;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;endomembrane system#GO:0012505;extracellular region#GO:0005576;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226 serine protease#PC00203 Alzheimer disease-presenilin pathway#P00004>Furin#P00157;Endothelin signaling pathway#P00019>furin#P00575;Alzheimer disease-amyloid secretase pathway#P00003>Furin#P00105 HUMAN|HGNC=1712|UniProtKB=P32320 P32320 CDA PTHR11644:SF2 CYTIDINE DEAMINASE CYTIDINE DEAMINASE catalytic activity#GO:0003824;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity#GO:0016787;deaminase activity#GO:0019239;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814 nucleobase-containing small molecule catabolic process#GO:0034656;primary metabolic process#GO:0044238;small molecule catabolic process#GO:0044282;carbohydrate derivative catabolic process#GO:1901136;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;nucleoside metabolic process#GO:0009116;nucleoside catabolic process#GO:0009164;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;pyrimidine-containing compound metabolic process#GO:0072527;nucleobase-containing compound catabolic process#GO:0034655;glycosyl compound catabolic process#GO:1901658;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative biosynthetic process#GO:1901137 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 deaminase#PC00088 Pyrimidine Metabolism#P02771>Cytidine Deaminase#P03130;Salvage pyrimidine ribonucleotides#P02775>Cytidine deaminase#P03154;Salvage pyrimidine deoxyribonucleotides#P02774>Cytidine deaminase#P03144 HUMAN|HGNC=11857|UniProtKB=O14894 O14894 TM4SF5 PTHR14198:SF4 TRANSMEMBRANE 4 L6 FAMILY MEMBER 1-RELATED TRANSMEMBRANE 4 L6 FAMILY MEMBER 5 membrane#GO:0016020;cellular anatomical structure#GO:0110165 HUMAN|HGNC=4741|UniProtKB=P0C0S5 P0C0S5 H2AZ1 PTHR23430:SF47 HISTONE H2A HISTONE H2A.Z structural molecule activity#GO:0005198 regulation of gene expression#GO:0010468;negative regulation of gene expression, epigenetic#GO:0045814;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;negative regulation of cellular process#GO:0048523;heterochromatin organization#GO:0070828;chromatin organization#GO:0006325;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;cellular component assembly#GO:0022607;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;epigenetic regulation of gene expression#GO:0040029;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;heterochromatin formation#GO:0031507;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519 membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;protein-DNA complex#GO:0032993;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;nucleosome#GO:0000786;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;chromatin#GO:0000785;nucleus#GO:0005634 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=30136|UniProtKB=Q96B96 Q96B96 LDAF1 PTHR14275:SF0 PROMETHIN LIPID DROPLET ASSEMBLY FACTOR 1 HUMAN|HGNC=12851|UniProtKB=P62258 P62258 YWHAE PTHR18860:SF67 14-3-3 PROTEIN 14-3-3 PROTEIN EPSILON binding#GO:0005488;protein binding#GO:0005515 regulation of mitotic cell cycle#GO:0007346;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of cell cycle#GO:0051726 scaffold/adaptor protein#PC00226 EGF receptor signaling pathway#P00018>14-3-3#P00539;FGF signaling pathway#P00021>14-3-3#P00624;Parkinson disease#P00049>14-3-3#P01238 HUMAN|HGNC=17028|UniProtKB=Q96H20 Q96H20 SNF8 PTHR12806:SF1 EAP30 SUBUNIT OF ELL COMPLEX VACUOLAR-SORTING PROTEIN SNF8 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043162;endosome transport via multivesicular body sorting pathway#GO:0032509;late endosome to vacuole transport via multivesicular body sorting pathway#GO:0032511;multivesicular body sorting pathway#GO:0071985;macromolecule localization#GO:0033036;ubiquitin-dependent protein catabolic process#GO:0006511;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;establishment of protein localization to organelle#GO:0072594;transport#GO:0006810;vacuolar transport#GO:0007034;intracellular transport#GO:0046907;protein localization to organelle#GO:0033365;catabolic process#GO:0009056;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;localization#GO:0051179;protein localization to vacuole#GO:0072665;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;endosomal transport#GO:0016197;intracellular protein transport#GO:0006886;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043328;late endosome to vacuole transport#GO:0045324;establishment of protein localization to vacuole#GO:0072666;protein transport#GO:0015031;cellular localization#GO:0051641;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163 endosome#GO:0005768;endosome membrane#GO:0010008;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane#GO:0016020;vesicle membrane#GO:0012506;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;protein-containing complex#GO:0032991 HUMAN|HGNC=53856|UniProtKB=A0A1W2PPH5 A0A1W2PPH5 TAF11L13 PTHR13218:SF18 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11-RELATED TATA-BOX-BINDING PROTEIN-ASSOCIATED FACTOR 11-LIKE PROTEIN 10-RELATED nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;DNA-templated transcription initiation#GO:0006352;RNA biosynthetic process#GO:0032774;RNA polymerase II preinitiation complex assembly#GO:0051123;DNA-templated transcription#GO:0006351;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;transcription by RNA polymerase II#GO:0006366;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-DNA complex organization#GO:0071824;protein-containing complex organization#GO:0043933;transcription initiation at RNA polymerase II promoter#GO:0006367;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component assembly#GO:0022607;gene expression#GO:0010467;protein-DNA complex assembly#GO:0065004;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139 intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;RNA polymerase II, holoenzyme#GO:0016591;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;transcription factor TFIID complex#GO:0005669;protein-containing complex#GO:0032991;RNA polymerase complex#GO:0030880;nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;membrane-enclosed lumen#GO:0031974;transcription regulator complex#GO:0005667;intracellular protein-containing complex#GO:0140535;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234 RNA metabolism protein#PC00031;general transcription factor#PC00259 HUMAN|HGNC=938|UniProtKB=O95816 O95816 BAG2 PTHR12334:SF6 BAG FAMILY MOLECULAR CHAPERONE REGULATOR 2 BAG FAMILY MOLECULAR CHAPERONE REGULATOR 2 molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589 regulation of protein stability#GO:0031647;protein stabilization#GO:0050821;regulation of biological quality#GO:0065008;biological regulation#GO:0065007 chaperone#PC00072 HUMAN|HGNC=20388|UniProtKB=Q9BQ08 Q9BQ08 RETNLB PTHR21101:SF13 RESISTIN RESISTIN-LIKE BETA molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;hormone activity#GO:0005179;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545 epithelial cell proliferation#GO:0050673;cell population proliferation#GO:0008283;cellular process#GO:0009987 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=28399|UniProtKB=Q8NEK8 Q8NEK8 TENT5D PTHR12974:SF30 PRION-LIKE- Q/N-RICH -DOMAIN-BEARING PROTEIN PROTEIN 44 TERMINAL NUCLEOTIDYLTRANSFERASE 5D catalytic activity#GO:0003824;transferase activity#GO:0016740;nucleotidyltransferase activity#GO:0016779;transferase activity, transferring phosphorus-containing groups#GO:0016772;adenylyltransferase activity#GO:0070566 negative regulation of RNA metabolic process#GO:0051253;regulation of mRNA metabolic process#GO:1903311;positive regulation of biological process#GO:0048518;mRNA stabilization#GO:0048255;positive regulation of macromolecule metabolic process#GO:0010604;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of biological quality#GO:0065008;RNA stabilization#GO:0043489;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;regulation of mRNA stability#GO:0043488;negative regulation of metabolic process#GO:0009892;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of RNA catabolic process#GO:1902369;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;positive regulation of gene expression#GO:0010628;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA stability#GO:0043487;regulation of RNA metabolic process#GO:0051252;negative regulation of catabolic process#GO:0009895;positive regulation of biosynthetic process#GO:0009891;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255 HUMAN|HGNC=20229|UniProtKB=Q8WV16 Q8WV16 DCAF4 PTHR44472:SF3 DDB1- AND CUL4-ASSOCIATED FACTOR 4-RELATED DDB1- AND CUL4-ASSOCIATED FACTOR 4 protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535;catalytic complex#GO:1902494;transferase complex#GO:1990234;Cul4-RING E3 ubiquitin ligase complex#GO:0080008 HUMAN|HGNC=22194|UniProtKB=Q6PID8 Q6PID8 KLHDC10 PTHR46428:SF1 KELCH DOMAIN-CONTAINING PROTEIN 10 KELCH DOMAIN-CONTAINING PROTEIN 10 positive regulation of MAPK cascade#GO:0043410;regulation of response to stress#GO:0080134;positive regulation of intracellular signal transduction#GO:1902533;regulation of MAPK cascade#GO:0043408;regulation of response to stimulus#GO:0048583;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of signaling#GO:0023056;regulation of cellular response to stress#GO:0080135;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789 HUMAN|HGNC=6121|UniProtKB=O14896 O14896 IRF6 PTHR11949:SF9 INTERFERON REGULATORY FACTOR INTERFERON REGULATORY FACTOR 6 DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 DNA-binding transcription factor#PC00218;winged helix/forkhead transcription factor#PC00246 HUMAN|HGNC=16165|UniProtKB=Q9H410 Q9H410 DSN1 PTHR14778:SF2 KINETOCHORE-ASSOCIATED PROTEIN DSN1 HOMOLOG KINETOCHORE-ASSOCIATED PROTEIN DSN1 HOMOLOG intracellular organelle#GO:0043229;chromosome, centromeric region#GO:0000775;condensed chromosome#GO:0000793;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;outer kinetochore#GO:0000940;membraneless organelle#GO:0043228;kinetochore#GO:0000776;condensed chromosome, centromeric region#GO:0000779;chromosome#GO:0005694;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;supramolecular complex#GO:0099080;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 HUMAN|HGNC=17655|UniProtKB=Q9H772 Q9H772 GREM2 PTHR15283:SF2 GREMLIN 1 GREMLIN-2 receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;cytokine binding#GO:0019955;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;binding#GO:0005488;molecular function activator activity#GO:0140677;protein binding#GO:0005515 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=37257|UniProtKB=Q8WVI0 Q8WVI0 UQCC5 PTHR35250:SF1 SMALL INTEGRAL MEMBRANE PROTEIN 4 UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX ASSEMBLY FACTOR 5 HUMAN|HGNC=843|UniProtKB=P48201 P48201 ATP5MC3 PTHR10031:SF59 ATP SYNTHASE LIPID-BINDING PROTEIN, MITOCHONDRIAL ATP SYNTHASE F(0) COMPLEX SUBUNIT C3, MITOCHONDRIAL ATP synthase#PC00002;primary active transporter#PC00068;transporter#PC00227 HUMAN|HGNC=27506|UniProtKB=Q8NBE8 Q8NBE8 KLHL23 PTHR24412:SF304 KELCH PROTEIN KELCH-LIKE PROTEIN 23 ubiquitin-like ligase-substrate adaptor activity#GO:1990756;enzyme-substrate adaptor activity#GO:0140767;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056 catalytic complex#GO:1902494;transferase complex#GO:1990234;ubiquitin ligase complex#GO:0000151;Cul3-RING ubiquitin ligase complex#GO:0031463;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;cullin-RING ubiquitin ligase complex#GO:0031461 scaffold/adaptor protein#PC00226 HUMAN|HGNC=18987|UniProtKB=Q9BU02 Q9BU02 THTPA PTHR14586:SF1 THIAMINE-TRIPHOSPHATASE THIAMINE-TRIPHOSPHATASE pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817;ion binding#GO:0043167;small molecule binding#GO:0036094;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;hydrolase activity#GO:0016787;metal ion binding#GO:0046872;cation binding#GO:0043169;magnesium ion binding#GO:0000287 pyrimidine-containing compound metabolic process#GO:0072527;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;metabolic process#GO:0008152;sulfur compound metabolic process#GO:0006790;phosphorus metabolic process#GO:0006793 metabolite interconversion enzyme#PC00262;phosphatase#PC00181 Thiamin metabolism#P02780>Thiamine triphosphatase#P03184 HUMAN|HGNC=30042|UniProtKB=Q9H008 Q9H008 LHPP PTHR19288:SF44 4-NITROPHENYLPHOSPHATASE-RELATED PHOSPHOLYSINE PHOSPHOHISTIDINE INORGANIC PYROPHOSPHATE PHOSPHATASE phosphoric ester hydrolase activity#GO:0042578;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 phosphatase#PC00181;hydrolase#PC00121 HUMAN|HGNC=2333|UniProtKB=Q66K79 Q66K79 CPZ PTHR11532:SF63 PROTEASE M14 CARBOXYPEPTIDASE CARBOXYPEPTIDASE Z exopeptidase activity#GO:0008238;metallocarboxypeptidase activity#GO:0004181;hydrolase activity#GO:0016787;carboxypeptidase activity#GO:0004180;metallopeptidase activity#GO:0008237;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;catalytic activity#GO:0003824;metalloexopeptidase activity#GO:0008235 primary metabolic process#GO:0044238;cellular process#GO:0009987;protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;proteolysis#GO:0006508;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;peptide metabolic process#GO:0006518 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease#PC00190 HUMAN|HGNC=27338|UniProtKB=Q8N807 Q8N807 PDILT PTHR18929:SF58 PROTEIN DISULFIDE ISOMERASE PROTEIN DISULFIDE-ISOMERASE-LIKE PROTEIN OF THE TESTIS protein disulfide isomerase activity#GO:0003756;catalytic activity#GO:0003824;isomerase activity#GO:0016853;catalytic activity, acting on a protein#GO:0140096;intramolecular oxidoreductase activity#GO:0016860 primary metabolic process#GO:0044238;response to stress#GO:0006950;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;macromolecule biosynthetic process#GO:0009059;protein maturation#GO:0051604;gene expression#GO:0010467;response to stimulus#GO:0050896;protein folding#GO:0006457;biosynthetic process#GO:0009058;response to endoplasmic reticulum stress#GO:0034976;metabolic process#GO:0008152;cellular response to stress#GO:0033554;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 chaperone#PC00072 HUMAN|HGNC=15673|UniProtKB=Q8WWQ0 Q8WWQ0 PHIP PTHR16266:SF4 WD REPEAT DOMAIN 9 PH-INTERACTING PROTEIN regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=25866|UniProtKB=Q9H7Y0 Q9H7Y0 DIPK2B PTHR32073:SF8 GH11358P DIVERGENT PROTEIN KINASE DOMAIN 2B HUMAN|HGNC=6168|UniProtKB=Q06033 Q06033 ITIH3 PTHR10338:SF115 INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H3 protein-binding activity modulator#PC00095;protease inhibitor#PC00191 HUMAN|HGNC=27709|UniProtKB=A2RUB6 A2RUB6 CCDC66 PTHR22736:SF3 COILED-COIL DOMAIN-CONTAINING PROTEIN 66 COILED-COIL DOMAIN-CONTAINING PROTEIN 66 protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;microtubule binding#GO:0008017;binding#GO:0005488 cell projection organization#GO:0030030;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;cellular component organization#GO:0016043;cilium assembly#GO:0060271;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782;plasma membrane bounded cell projection assembly#GO:0120031;organelle assembly#GO:0070925 cytoskeleton#GO:0005856;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232;photoreceptor inner segment#GO:0001917;intracellular organelle#GO:0043229;cilium#GO:0005929;microtubule#GO:0005874;supramolecular fiber#GO:0099512;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025 HUMAN|HGNC=18984|UniProtKB=Q8WYA1 Q8WYA1 BMAL2 PTHR23042:SF48 CIRCADIAN PROTEIN CLOCK/ARNT/BMAL/PAS BASIC HELIX-LOOP-HELIX ARNT-LIKE PROTEIN 2 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;signaling receptor complex#GO:0043235;intracellular organelle#GO:0043229;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 basic helix-loop-helix transcription factor#PC00055;gene-specific transcriptional regulator#PC00264 HUMAN|Gene=SNG2L_HUMAN|UniProtKB=A8MWL6 A8MWL6 PTHR10838:SF19 SYNAPTOGYRIN SYNAPTOGYRIN-2 LIKE PROTEIN-RELATED cellular process#GO:0009987;cellular component organization#GO:0016043;synaptic vesicle membrane organization#GO:0048499;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;export from cell#GO:0140352;vesicle-mediated transport#GO:0016192;transport#GO:0006810;regulated exocytosis#GO:0045055;secretion by cell#GO:0032940;exocytosis#GO:0006887;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;secretion#GO:0046903 presynapse#GO:0098793;secretory vesicle#GO:0099503;cytoplasm#GO:0005737;transport vesicle#GO:0030133;endomembrane system#GO:0012505;cell junction#GO:0030054;vesicle#GO:0031982;synaptic vesicle#GO:0008021;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622 membrane trafficking regulatory protein#PC00151;membrane traffic protein#PC00150 HUMAN|HGNC=16945|UniProtKB=Q9H074 Q9H074 PAIP1 PTHR23254:SF15 EIF4G DOMAIN PROTEIN POLYADENYLATE-BINDING PROTEIN-INTERACTING PROTEIN 1 translation regulator activity#GO:0045182 biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of protein metabolic process#GO:0051246;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of translational initiation#GO:0006446;post-transcriptional regulation of gene expression#GO:0010608 RNA metabolism protein#PC00031 HUMAN|HGNC=25232|UniProtKB=Q5TI25 Q5TI25 NBPF14 PTHR14199:SF35 NEUROBLASTOMA BREAKPOINT FAMILY MEMBER 6-LIKE PROTEIN NBPF FAMILY MEMBER NBPF1-RELATED HUMAN|HGNC=12228|UniProtKB=P0DPF7 P0DPF7 TRBV6-3 PTHR23268:SF19 T-CELL RECEPTOR BETA CHAIN T CELL RECEPTOR BETA VARIABLE 6-2-RELATED cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=10781|UniProtKB=P62995 P62995 TRA2B PTHR48034:SF1 TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED TRANSFORMER-2 PROTEIN HOMOLOG BETA nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;RNA binding#GO:0003723 nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;mRNA processing#GO:0006397;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170 nucleus#GO:0005634;spliceosomal complex#GO:0005681;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513 RNA metabolism protein#PC00031 HUMAN|HGNC=30589|UniProtKB=Q9BQS6 Q9BQS6 HSPB9 PTHR47896:SF1 HEAT SHOCK PROTEIN BETA-9 HEAT SHOCK PROTEIN BETA-9 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=13168|UniProtKB=Q03936 Q03936 ZNF92 PTHR24384:SF211 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED ZINC FINGER PROTEIN 138-RELATED sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218 HUMAN|HGNC=14948|UniProtKB=Q96I51 Q96I51 RCC1L PTHR46337:SF1 RCC1-LIKE G EXCHANGING FACTOR-LIKE PROTEIN RCC1-LIKE G EXCHANGING FACTOR-LIKE PROTEIN guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589 organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;mitochondrial fusion#GO:0008053;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;cellular process#GO:0009987;cellular component assembly#GO:0022607;organelle fusion#GO:0048284;mitochondrion organization#GO:0007005;ribonucleoprotein complex biogenesis#GO:0022613;organelle assembly#GO:0070925;ribosome assembly#GO:0042255;ribosome biogenesis#GO:0042254;cellular component organization or biogenesis#GO:0071840;mitochondrial ribosome assembly#GO:0061668 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrial inner membrane#GO:0005743;organelle envelope#GO:0031967;membrane#GO:0016020;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740 HUMAN|HGNC=29625|UniProtKB=A1L453 A1L453 PRSS38 PTHR24250:SF30 CHYMOTRYPSIN-RELATED SERINE PROTEASE 38 catalytic activity#GO:0003824;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;proteolysis#GO:0006508;primary metabolic process#GO:0044238;cellular process#GO:0009987 protein modifying enzyme#PC00260;serine protease#PC00203 HUMAN|HGNC=26337|UniProtKB=Q76KX8 Q76KX8 ZNF534 PTHR24377:SF854 IP01015P-RELATED ZINC FINGER PROTEIN 534 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=1994|UniProtKB=P06732 P06732 CKM PTHR11547:SF63 ARGININE OR CREATINE KINASE CREATINE KINASE M-TYPE transferase activity#GO:0016740;catalytic activity#GO:0003824;phosphotransferase activity, nitrogenous group as acceptor#GO:0016775;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 organophosphate biosynthetic process#GO:0090407;biosynthetic process#GO:0009058;modified amino acid metabolic process#GO:0006575;phosphorus metabolic process#GO:0006793;organophosphate metabolic process#GO:0019637;metabolic process#GO:0008152;cellular process#GO:0009987 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;amino acid kinase#PC00045 HUMAN|HGNC=9262|UniProtKB=Q9H2H8 Q9H2H8 PPIL3 PTHR45625:SF2 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 3 peptidyl-prolyl cis-trans isomerase activity#GO:0003755;isomerase activity#GO:0016853;cis-trans isomerase activity#GO:0016859;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;catalytic step 2 spliceosome#GO:0071013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ribonucleoprotein complex#GO:1990904;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;spliceosomal complex#GO:0005681 chaperone#PC00072 HUMAN|HGNC=24953|UniProtKB=O94992 O94992 HEXIM1 PTHR13469:SF7 HEXAMETHYLENE BISACETAMIDE INDUCIBLE 1 PROTEIN HEXIM1 nucleic acid binding#GO:0003676;binding#GO:0005488;enzyme regulator activity#GO:0030234;snRNA binding#GO:0017069;RNA binding#GO:0003723;molecular function inhibitor activity#GO:0140678;cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538;enzyme inhibitor activity#GO:0004857;kinase inhibitor activity#GO:0019210;cyclin-dependent protein kinase regulator activity#GO:0019914;protein kinase regulator activity#GO:0019887;kinase regulator activity#GO:0019207;protein kinase inhibitor activity#GO:0004860;cyclin-dependent protein serine/threonine kinase inhibitor activity#GO:0004861;molecular function regulator activity#GO:0098772 negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892 nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=16930|UniProtKB=Q8IWX8 Q8IWX8 CHERP PTHR12323:SF0 SR-RELATED CTD ASSOCIATED FACTOR 6 CALCIUM HOMEOSTASIS ENDOPLASMIC RETICULUM PROTEIN homeostatic process#GO:0042592;monoatomic ion homeostasis#GO:0050801;intracellular monoatomic ion homeostasis#GO:0006873;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;calcium ion homeostasis#GO:0055074;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;inorganic ion homeostasis#GO:0098771;intracellular monoatomic cation homeostasis#GO:0030003 cellular anatomical structure#GO:0110165;perinuclear region of cytoplasm#GO:0048471;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 RNA metabolism protein#PC00031 HUMAN|HGNC=245|UniProtKB=Q9UEY8 Q9UEY8 ADD3 PTHR10672:SF5 ADDUCIN GAMMA-ADDUCIN protein-containing complex binding#GO:0044877;protein binding#GO:0005515;actin filament binding#GO:0051015;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;binding#GO:0005488 regulation of anatomical structure size#GO:0090066;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;regulation of protein-containing complex disassembly#GO:0043244;regulation of actin cytoskeleton organization#GO:0032956;regulation of actin filament length#GO:0030832;negative regulation of actin filament depolymerization#GO:0030835;regulation of biological quality#GO:0065008;regulation of organelle organization#GO:0033043;regulation of cellular component size#GO:0032535;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;regulation of protein-containing complex assembly#GO:0043254;negative regulation of biological process#GO:0048519;regulation of cellular component biogenesis#GO:0044087;negative regulation of actin filament polymerization#GO:0030837;regulation of cellular component organization#GO:0051128;regulation of actin filament-based process#GO:0032970;negative regulation of cellular process#GO:0048523;regulation of protein depolymerization#GO:1901879;regulation of actin filament organization#GO:0110053;negative regulation of protein depolymerization#GO:1901880;biological regulation#GO:0065007;regulation of actin polymerization or depolymerization#GO:0008064;regulation of actin filament polymerization#GO:0030833;negative regulation of protein polymerization#GO:0032272;actin filament capping#GO:0051693;negative regulation of protein-containing complex assembly#GO:0031333;negative regulation of protein-containing complex disassembly#GO:0043242;negative regulation of cytoskeleton organization#GO:0051494;regulation of supramolecular fiber organization#GO:1902903;negative regulation of organelle organization#GO:0010639;negative regulation of cellular component organization#GO:0051129;regulation of actin filament depolymerization#GO:0030834;regulation of cellular process#GO:0050794;negative regulation of supramolecular fiber organization#GO:1902904;regulation of cytoskeleton organization#GO:0051493;regulation of protein polymerization#GO:0032271 intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;postsynaptic specialization#GO:0099572;neuron to neuron synapse#GO:0098984;cell periphery#GO:0071944;membrane#GO:0016020;cell junction#GO:0030054;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;asymmetric synapse#GO:0032279;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;postsynapse#GO:0098794;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;postsynaptic density#GO:0014069 non-motor actin binding protein#PC00165 HUMAN|HGNC=6884|UniProtKB=Q9UPT6 Q9UPT6 MAPK8IP3 PTHR13886:SF3 JNK/SAPK-ASSOCIATED PROTEIN C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 3 signaling adaptor activity#GO:0035591;protein binding#GO:0005515;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;kinase binding#GO:0019900;binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;structural molecule activity#GO:0005198;MAP kinase scaffold activity#GO:0005078;protein complex scaffold activity#GO:0140378;cytoskeletal protein binding#GO:0008092;signaling receptor complex adaptor activity#GO:0030159;molecular adaptor activity#GO:0060090 localization#GO:0051179;establishment of localization#GO:0051234;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;transport#GO:0006810 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HUMAN|HGNC=21362|UniProtKB=Q8IXS0 Q8IXS0 FAM217A PTHR22145:SF4 SI:CH211-266K22.6 PROTEIN FAM217A HUMAN|HGNC=34024|UniProtKB=Q6ZNK6 Q6ZNK6 TIFAB PTHR31266:SF3 TRAF-INTERACTING PROTEIN WITH FHA DOMAIN-CONTAINING PROTEIN A FAMILY MEMBER TRAF-INTERACTING PROTEIN WITH FHA DOMAIN-CONTAINING PROTEIN B enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme activator activity#GO:0008047;peptidase activator activity#GO:0016504;peptidase regulator activity#GO:0061134 biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;positive regulation of innate immune response#GO:0045089;activation of innate immune response#GO:0002218;pattern recognition receptor signaling pathway#GO:0002221;positive regulation of response to biotic stimulus#GO:0002833;regulation of innate immune response#GO:0045088;regulation of response to stimulus#GO:0048583;positive regulation of defense response#GO:0031349;positive regulation of immune response#GO:0050778;regulation of response to stress#GO:0080134;regulation of response to biotic stimulus#GO:0002831;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;innate immune response-activating signaling pathway#GO:0002758;cell communication#GO:0007154;regulation of defense response#GO:0031347;regulation of immune response#GO:0050776;regulation of response to external stimulus#GO:0032101;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;signal transduction#GO:0007165;positive regulation of immune system process#GO:0002684;positive regulation of response to external stimulus#GO:0032103;immune response-activating signaling pathway#GO:0002757;signaling#GO:0023052;response to stimulus#GO:0050896;immune response-regulating signaling pathway#GO:0002764;regulation of biological process#GO:0050789;toll-like receptor signaling pathway#GO:0002224;immune system process#GO:0002376 HUMAN|HGNC=24925|UniProtKB=Q9BWH2 Q9BWH2 FUNDC2 PTHR21346:SF5 FUN14 DOMAIN CONTAINING FUN14 DOMAIN-CONTAINING PROTEIN 2 catabolic process#GO:0009056;process utilizing autophagic mechanism#GO:0061919;autophagy of mitochondrion#GO:0000422;metabolic process#GO:0008152;cellular process#GO:0009987;autophagy#GO:0006914 intracellular organelle#GO:0043229;outer membrane#GO:0019867;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle envelope#GO:0031967;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;mitochondrial outer membrane#GO:0005741;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane#GO:0016020;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;organelle outer membrane#GO:0031968;cytoplasm#GO:0005737 HUMAN|HGNC=11785|UniProtKB=P07996 P07996 THBS1 PTHR10199:SF78 THROMBOSPONDIN THROMBOSPONDIN-1 extracellular matrix structural constituent#GO:0005201;structural molecule activity#GO:0005198 regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of developmental process#GO:0050793;regulation of multicellular organismal process#GO:0051239;negative regulation of multicellular organismal process#GO:0051241;negative regulation of biological process#GO:0048519;negative regulation of cell population proliferation#GO:0008285;regulation of biological process#GO:0050789;regulation of multicellular organismal development#GO:2000026;regulation of cell population proliferation#GO:0042127;negative regulation of angiogenesis#GO:0016525;regulation of anatomical structure morphogenesis#GO:0022603;regulation of angiogenesis#GO:0045765;negative regulation of cellular process#GO:0048523;regulation of vasculature development#GO:1901342 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 cell adhesion molecule#PC00069 p53 pathway#P00059>TSP1#G01566 HUMAN|HGNC=24252|UniProtKB=Q96GK7 Q96GK7 FAHD2A PTHR42796:SF3 FUMARYLACETOACETATE HYDROLASE DOMAIN-CONTAINING PROTEIN 2A-RELATED OXALOACETATE TAUTOMERASE FAHD2A, MITOCHONDRIAL-RELATED hydrolase#PC00121 HUMAN|HGNC=3263|UniProtKB=Q9UKV8 Q9UKV8 AGO2 PTHR22891:SF59 EUKARYOTIC TRANSLATION INITIATION FACTOR 2C PROTEIN ARGONAUTE-2 catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;RNA nuclease activity#GO:0004540;endonuclease activity#GO:0004519;single-stranded RNA binding#GO:0003727;RNA endonuclease activity#GO:0004521;catalytic activity, acting on RNA#GO:0140098;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723;nuclease activity#GO:0004518 RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;negative regulation of metabolic process#GO:0009892;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;miRNA processing#GO:0035196;biological regulation#GO:0065007;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;macromolecule biosynthetic process#GO:0009059;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulatory ncRNA processing#GO:0070918;macromolecule metabolic process#GO:0043170;regulatory ncRNA-mediated gene silencing#GO:0031047;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;pre-miRNA processing#GO:0031054;regulation of macromolecule metabolic process#GO:0060255;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;post-transcriptional gene silencing#GO:0016441;regulatory ncRNA-mediated post-transcriptional gene silencing#GO:0035194 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;nucleus#GO:0005634 translational protein#PC00263;translation factor#PC00223;translation initiation factor#PC00224 HUMAN|HGNC=33550|UniProtKB=Q68CJ6 Q68CJ6 NUGGC PTHR47308:SF1 NUCLEAR GTPASE SLIP-GC NUCLEAR GTPASE SLIP-GC hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787 HUMAN|HGNC=32470|UniProtKB=Q6ZMV8 Q6ZMV8 ZNF730 PTHR24384:SF110 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED ZINC FINGER PROTEIN 730-RELATED sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 DNA-binding transcription factor#PC00218 HUMAN|HGNC=5478|UniProtKB=P01876 P01876 IGHA1 PTHR23411:SF31 TAPASIN IMMUNOGLOBULIN HEAVY CONSTANT ALPHA 1-RELATED protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488;antigen binding#GO:0003823 immune system process#GO:0002376;defense response to bacterium#GO:0042742;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;antimicrobial humoral response#GO:0019730;humoral immune response#GO:0006959;immune effector process#GO:0002252;antibacterial humoral response#GO:0019731;response to stress#GO:0006950;positive regulation of immune system process#GO:0002684;response to biotic stimulus#GO:0009607;defense response to symbiont#GO:0140546;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;defense response to other organism#GO:0098542;response to bacterium#GO:0009617;regulation of immune response#GO:0050776;regulation of immune system process#GO:0002682;response to external biotic stimulus#GO:0043207;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778;defense response#GO:0006952;response to external stimulus#GO:0009605;complement activation#GO:0006956;immune response#GO:0006955;positive regulation of response to stimulus#GO:0048584;adaptive immune response#GO:0002250;response to other organism#GO:0051707;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;extracellular region#GO:0005576;extracellular protein-containing complex#GO:0140392 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=19753|UniProtKB=Q9H2X8 Q9H2X8 IFI27L2 PTHR16932:SF35 INTERFERON ALPHA-INDUCIBLE PROTEIN 27 INTERFERON ALPHA-INDUCIBLE PROTEIN 27-LIKE PROTEIN 2 response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;programmed cell death#GO:0012501;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell death#GO:0008219;apoptotic process#GO:0006915;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;apoptotic signaling pathway#GO:0097190;intrinsic apoptotic signaling pathway#GO:0097193;intracellular signal transduction#GO:0035556 membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle envelope#GO:0031967;membrane#GO:0016020;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;mitochondrial envelope#GO:0005740 HUMAN|HGNC=76|UniProtKB=P00519 P00519 ABL1 PTHR24418:SF438 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE ABL1 catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein tyrosine kinase activity#GO:0004713;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165;positive regulation of cell migration#GO:0030335;ERBB signaling pathway#GO:0038127;cellular process#GO:0009987;epidermal growth factor receptor signaling pathway#GO:0007173;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;regulation of cell migration#GO:0030334;cell surface receptor signaling pathway#GO:0007166;positive regulation of locomotion#GO:0040017;positive regulation of cell motility#GO:2000147;integrin-mediated signaling pathway#GO:0007229;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cell communication#GO:0007154;regulation of cell motility#GO:2000145;enzyme-linked receptor protein signaling pathway#GO:0007167 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 non-receptor tyrosine protein kinase#PC00168 Axon guidance mediated by Slit/Robo#P00008>Abl#P00347;Integrin signalling pathway#P00034>Abl#P00946 HUMAN|HGNC=28158|UniProtKB=Q8NBP5 Q8NBP5 SLC67A2 PTHR23504:SF14 MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10 SOLUTE CARRIER FAMILY 67 MEMBER A2 transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 membrane#GO:0016020;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258;transporter#PC00227 HUMAN|HGNC=14539|UniProtKB=Q63HN8 Q63HN8 RNF213 PTHR22605:SF16 RZ-TYPE DOMAIN-CONTAINING PROTEIN E3 UBIQUITIN-PROTEIN LIGASE RNF213 acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;ubiquitin-protein transferase activity#GO:0004842 primary metabolic process#GO:0044238;tube morphogenesis#GO:0035239;blood vessel development#GO:0001568;modification-dependent protein catabolic process#GO:0019941;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of cell communication#GO:0010646;protein metabolic process#GO:0019538;anatomical structure development#GO:0048856;system development#GO:0048731;negative regulation of response to stimulus#GO:0048585;negative regulation of Wnt signaling pathway#GO:0030178;multicellular organismal process#GO:0032501;tube development#GO:0035295;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;developmental process#GO:0032502;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;blood vessel morphogenesis#GO:0048514;negative regulation of biological process#GO:0048519;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;circulatory system development#GO:0072359;regulation of Wnt signaling pathway#GO:0030111;animal gross anatomical part developmental process#GO:0160108;sprouting angiogenesis#GO:0002040;negative regulation of signaling#GO:0023057;modification-dependent macromolecule catabolic process#GO:0043632;regulation of signaling#GO:0023051;protein catabolic process#GO:0030163;angiogenesis#GO:0001525;negative regulation of cell communication#GO:0010648;cellular process#GO:0009987;negative regulation of signal transduction#GO:0009968;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;multicellular organism development#GO:0007275;anatomical structure formation involved in morphogenesis#GO:0048646;vasculature development#GO:0001944 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 HUMAN|HGNC=15784|UniProtKB=Q96C45 Q96C45 ULK4 PTHR46240:SF1 SER/THR PROTEIN KINASE ULK4 INACTIVE SERINE_THREONINE-PROTEIN KINASE ULK4 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=5657|UniProtKB=P0DP08 P0DP08 IGHV4-38-2 PTHR23266:SF365 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 4-38-2 antigen binding#GO:0003823;binding#GO:0005488 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449;immune effector process#GO:0002252;immune system process#GO:0002376;adaptive immune response#GO:0002250;response to stimulus#GO:0050896;immune response#GO:0006955 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=5480|UniProtKB=P01880 P01880 IGHD PTHR23411:SF59 TAPASIN IMMUNOGLOBULIN HEAVY CONSTANT DELTA protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102;antigen binding#GO:0003823 biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;defense response to bacterium#GO:0042742;immune system process#GO:0002376;defense response to other organism#GO:0098542;activation of immune response#GO:0002253;positive regulation of biological process#GO:0048518;defense response to symbiont#GO:0140546;positive regulation of immune system process#GO:0002684;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;antibacterial humoral response#GO:0019731;immune effector process#GO:0002252;humoral immune response#GO:0006959;antimicrobial humoral response#GO:0019730;response to external biotic stimulus#GO:0043207;regulation of immune system process#GO:0002682;regulation of immune response#GO:0050776;response to bacterium#GO:0009617;response to other organism#GO:0051707;adaptive immune response#GO:0002250;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;complement activation#GO:0006956;immune response#GO:0006955;defense response#GO:0006952;response to external stimulus#GO:0009605;regulation of response to stimulus#GO:0048583;positive regulation of immune response#GO:0050778 extracellular protein-containing complex#GO:0140392;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=52392|UniProtKB=A0A1B0GUX0 A0A1B0GUX0 SPMIP1 PTHR35826:SF2 PROTEIN ATP6V1FNB-LIKE PROTEIN SPMIP1 HUMAN|HGNC=19037|UniProtKB=O15021 O15021 MAST4 PTHR24356:SF224 SERINE/THREONINE-PROTEIN KINASE MICROTUBULE-ASSOCIATED SERINE_THREONINE-PROTEIN KINASE 4 kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 cellular component organization#GO:0016043;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of cell cycle#GO:0051726;signaling#GO:0023052;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;organelle organization#GO:0006996;regulation of mitotic cell cycle#GO:0007346;cellular process#GO:0009987;signal transduction#GO:0007165;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;cellular component organization or biogenesis#GO:0071840 microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=7179|UniProtKB=Q02252 Q02252 ALDH6A1 PTHR43866:SF3 MALONATE-SEMIALDEHYDE DEHYDROGENASE METHYLMALONATE-SEMIALDEHYDE_MALONATE-SEMIALDEHYDE DEHYDROGENASE [ACYLATING], MITOCHONDRIAL oxidoreductase activity, acting on the aldehyde or oxo group of donors#GO:0016903;catalytic activity#GO:0003824;oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor#GO:0016620;oxidoreductase activity#GO:0016491 oxoacid metabolic process#GO:0043436;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;small molecule catabolic process#GO:0044282;nucleobase catabolic process#GO:0046113;pyrimidine nucleobase catabolic process#GO:0006208;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;pyrimidine nucleobase metabolic process#GO:0006206;nucleobase metabolic process#GO:0009112;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;proteinogenic amino acid metabolic process#GO:0170039;amino acid metabolic process#GO:0006520;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;pyrimidine-containing compound metabolic process#GO:0072527;carboxylic acid catabolic process#GO:0046395 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 Pyrimidine Metabolism#P02771>Methylmalonate Semialdehyde Dehydrogenase#P03124 HUMAN|HGNC=6112|UniProtKB=P51617 P51617 IRAK1 PTHR24419:SF1 INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1 protein kinase activity#GO:0004672;histone modifying activity#GO:0140993;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;histone kinase activity#GO:0035173;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824 cytokine-mediated signaling pathway#GO:0019221;regulation of immune response#GO:0050776;regulation of defense response#GO:0031347;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of cell communication#GO:0010646;cell cycle#GO:0007049;innate immune response-activating signaling pathway#GO:0002758;positive regulation of signal transduction#GO:0009967;cellular response to biotic stimulus#GO:0071216;cellular response to stimulus#GO:0051716;regulation of innate immune response#GO:0045088;innate immune response#GO:0045087;positive regulation of response to biotic stimulus#GO:0002833;pattern recognition receptor signaling pathway#GO:0002221;defense response#GO:0006952;positive regulation of defense response#GO:0031349;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;immune response-regulating cell surface receptor signaling pathway#GO:0002768;positive regulation of cellular process#GO:0048522;immune response#GO:0006955;regulation of canonical NF-kappaB signal transduction#GO:0043122;immune system process#GO:0002376;cellular response to chemical stimulus#GO:0070887;regulation of signaling#GO:0023051;response to stimulus#GO:0050896;response to molecule of bacterial origin#GO:0002237;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;immune response-regulating signaling pathway#GO:0002764;immune response-activating signaling pathway#GO:0002757;response to lipopolysaccharide#GO:0032496;cellular response to lipid#GO:0071396;regulation of response to external stimulus#GO:0032101;defense response to other organism#GO:0098542;response to biotic stimulus#GO:0009607;positive regulation of immune system process#GO:0002684;defense response to symbiont#GO:0140546;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;activation of immune response#GO:0002253;cellular process#GO:0009987;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;lipopolysaccharide-mediated signaling pathway#GO:0031663;response to bacterium#GO:0009617;mitotic cell cycle#GO:0000278;positive regulation of cell communication#GO:0010647;response to external biotic stimulus#GO:0043207;immune response-activating cell surface receptor signaling pathway#GO:0002429;regulation of response to biotic stimulus#GO:0002831;cellular response to molecule of bacterial origin#GO:0071219;response to external stimulus#GO:0009605;regulation of response to stress#GO:0080134;positive regulation of intracellular signal transduction#GO:1902533;toll-like receptor 4 signaling pathway#GO:0034142;regulation of signal transduction#GO:0009966;response to other organism#GO:0051707;activation of innate immune response#GO:0002218;positive regulation of innate immune response#GO:0045089;positive regulation of signaling#GO:0023056;response to peptide#GO:1901652;regulation of intracellular signal transduction#GO:1902531;response to oxygen-containing compound#GO:1901700;signaling#GO:0023052;biological process involved in interspecies interaction between organisms#GO:0044419;positive regulation of canonical NF-kappaB signal transduction#GO:0043123;positive regulation of response to external stimulus#GO:0032103;cell surface receptor signaling pathway#GO:0007166;response to cytokine#GO:0034097;response to chemical#GO:0042221;response to lipid#GO:0033993;response to stress#GO:0006950;cellular response to lipopolysaccharide#GO:0071222 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;cell periphery#GO:0071944;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;plasma membrane#GO:0005886 non-receptor serine/threonine protein kinase#PC00167 Toll receptor signaling pathway#P00054>IRAK1#P01343 HUMAN|HGNC=1357|UniProtKB=Q9NR00 Q9NR00 TCIM PTHR32358:SF1 TRANSCRIPTIONAL AND IMMUNE RESPONSE REGULATOR TRANSCRIPTIONAL AND IMMUNE RESPONSE REGULATOR binding#GO:0005488;signaling receptor binding#GO:0005102;protein binding#GO:0005515 biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of signal transduction#GO:0009968;negative regulation of response to stimulus#GO:0048585;multicellular organismal process#GO:0032501;immune response#GO:0006955;cellular process#GO:0009987;negative regulation of Notch signaling pathway#GO:0045746;regulation of response to stimulus#GO:0048583;immune effector process#GO:0002252;negative regulation of cellular process#GO:0048523;regulation of cell communication#GO:0010646;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of cell communication#GO:0010648;cell activation involved in immune response#GO:0002263;regulation of signaling#GO:0023051;cell activation#GO:0001775;regulation of Notch signaling pathway#GO:0008593;immune system process#GO:0002376;negative regulation of signaling#GO:0023057 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=17382|UniProtKB=Q7Z6B7 Q7Z6B7 SRGAP1 PTHR14166:SF15 SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 1 molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;enzyme activator activity#GO:0008047 regulation of biological quality#GO:0065008;system development#GO:0048731;regulation of synapse structure or activity#GO:0050803;anatomical structure development#GO:0048856;regulation of cell motility#GO:2000145;regulation of synapse organization#GO:0050807;regulation of cell junction assembly#GO:1901888;animal gross anatomical part developmental process#GO:0160108;regulation of cellular component biogenesis#GO:0044087;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;multicellular organism development#GO:0007275;regulation of cell migration#GO:0030334;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;negative regulation of cell migration#GO:0030336;nervous system development#GO:0007399;regulation of locomotion#GO:0040012;biological regulation#GO:0065007;negative regulation of locomotion#GO:0040013;negative regulation of cell motility#GO:2000146;multicellular organismal process#GO:0032501;regulation of synapse assembly#GO:0051963 G-protein modulator#PC00022;GTPase-activating protein#PC00257 PDGF signaling pathway#P00047>Rho#P01174;Axon guidance mediated by Slit/Robo#P00008>SrGAP#P00350 HUMAN|HGNC=25718|UniProtKB=Q8NF37 Q8NF37 LPCAT1 PTHR23063:SF57 PHOSPHOLIPID ACYLTRANSFERASE LYSOPHOSPHATIDYLCHOLINE ACYLTRANSFERASE 1 catalytic activity#GO:0003824;transferase activity#GO:0016740;acyltransferase activity#GO:0016746;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 metabolite interconversion enzyme#PC00262;transferase#PC00220;acyltransferase#PC00042 HUMAN|HGNC=746|UniProtKB=P04424 P04424 ASL PTHR43814:SF1 ARGININOSUCCINATE LYASE ARGININOSUCCINATE LYASE catalytic activity#GO:0003824;lyase activity#GO:0016829 small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;amino acid biosynthetic process#GO:0008652;L-arginine biosynthetic process#GO:0006526;proteinogenic amino acid biosynthetic process#GO:0170038;cellular process#GO:0009987;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;arginine metabolic process#GO:0006525;small molecule metabolic process#GO:0044281;proteinogenic amino acid metabolic process#GO:0170039 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 lyase#PC00144 Arginine biosynthesis#P02728>argininosuccinate lyase#P02841 HUMAN|HGNC=19290|UniProtKB=Q7Z408 Q7Z408 CSMD2 PTHR45656:SF6 PROTEIN CBR-CLEC-78 CUB AND SUSHI DOMAIN-CONTAINING PROTEIN 2 anatomical structure development#GO:0048856;system development#GO:0048731;postsynaptic specialization organization#GO:0099084;animal gross anatomical part developmental process#GO:0160108;organelle assembly#GO:0070925;postsynaptic density organization#GO:0097106;synapse organization#GO:0050808;cell junction organization#GO:0034330;synapse assembly#GO:0007416;excitatory synapse assembly#GO:1904861;postsynapse organization#GO:0099173;cellular component organization#GO:0016043;cell junction assembly#GO:0034329;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;developmental process#GO:0032502;multicellular organismal process#GO:0032501;cellular component assembly#GO:0022607;nervous system development#GO:0007399;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;postsynaptic density assembly#GO:0097107 postsynapse#GO:0098794;cellular anatomical structure#GO:0110165;synapse#GO:0045202;asymmetric synapse#GO:0032279;organelle#GO:0043226;postsynaptic density#GO:0014069;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;postsynaptic density membrane#GO:0098839;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;glutamatergic synapse#GO:0098978;neuron to neuron synapse#GO:0098984;plasma membrane region#GO:0098590;postsynaptic specialization#GO:0099572;synaptic membrane#GO:0097060;cell junction#GO:0030054 HUMAN|HGNC=29796|UniProtKB=Q9Y2Q5 Q9Y2Q5 LAMTOR2 PTHR13323:SF4 LATE ENDOSOMAL/LYSOSOMAL MP1 INTERACTING PROTEIN RAGULATOR COMPLEX PROTEIN LAMTOR2 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;protein-membrane adaptor activity#GO:0043495 positive regulation of TOR signaling#GO:0032008;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;cellular response to chemical stimulus#GO:0070887;regulation of intracellular signal transduction#GO:1902531;regulation of cell communication#GO:0010646;cellular response to amino acid stimulus#GO:0071230;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;regulation of TORC1 signaling#GO:1903432;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;response to chemical#GO:0042221;positive regulation of response to stimulus#GO:0048584;response to acid chemical#GO:0001101;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of TOR signaling#GO:0032006;cellular process#GO:0009987;positive regulation of TORC1 signaling#GO:1904263 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane protein complex#GO:0098796;organelle membrane#GO:0031090;intracellular protein-containing complex#GO:0140535;bounding membrane of organelle#GO:0098588;vacuolar membrane#GO:0005774;vacuole#GO:0005773;cytoplasm#GO:0005737;guanyl-nucleotide exchange factor complex#GO:0032045;protein-containing complex#GO:0032991;membrane#GO:0016020 HUMAN|HGNC=20588|UniProtKB=Q9UHG3 Q9UHG3 PCYOX1 PTHR15944:SF3 FARNESYLCYSTEINE LYASE PRENYLCYSTEINE OXIDASE 1 catalytic activity#GO:0003824;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;oxidoreductase activity#GO:0016491 catabolic process#GO:0009056;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057 metabolite interconversion enzyme#PC00262;lyase#PC00144 HUMAN|HGNC=26558|UniProtKB=Q96M11 Q96M11 HYLS1 PTHR34174:SF1 HYDROLETHALUS SYNDROME PROTEIN 1 CENTRIOLAR AND CILIOGENESIS-ASSOCIATED PROTEIN HYLS1 organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031;cilium organization#GO:0044782;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component organization#GO:0016043;cilium assembly#GO:0060271;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cell projection organization#GO:0030030 membrane-bounded organelle#GO:0043227;non-motile cilium#GO:0097730;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;cilium#GO:0005929;intracellular organelle#GO:0043229;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;cell projection#GO:0042995;centriole#GO:0005814;intracellular membraneless organelle#GO:0043232;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microtubule cytoskeleton#GO:0015630 HUMAN|HGNC=20223|UniProtKB=Q9H8Y1 Q9H8Y1 VRTN PTHR16081:SF0 VERTNIN VERTNIN regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;chromatin#GO:0000785;chromosome#GO:0005694 HUMAN|HGNC=13931|UniProtKB=Q8NDX9 Q8NDX9 LY6G5B PTHR14313:SF2 LYMPHOCYTE ANTIGEN 6 COMPLEX LOCUS PROTEIN G5B LYMPHOCYTE ANTIGEN 6 COMPLEX LOCUS PROTEIN G5B membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell surface#GO:0009986;plasma membrane#GO:0005886 HUMAN|HGNC=44672|UniProtKB=P0DMB2 P0DMB2 C8orf88 PTHR12669:SF15 EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN CHROMOSOME 8 OPEN READING FRAME 88 translation regulator activity#GO:0045182;translation initiation factor binding#GO:0031369;protein binding#GO:0005515;binding#GO:0005488 negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;regulation of translational initiation#GO:0006446;negative regulation of translation#GO:0017148;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 translation factor#PC00223;translation initiation factor#PC00224 HUMAN|HGNC=29262|UniProtKB=Q9P2H3 Q9P2H3 IFT80 PTHR24098:SF11 OUTER SEGMENT 5 INTRAFLAGELLAR TRANSPORT PROTEIN 80 HOMOLOG plasma membrane bounded cell projection assembly#GO:0120031;organelle assembly#GO:0070925;cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cell projection assembly#GO:0030031;cellular process#GO:0009987;cell projection organization#GO:0030030;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036 protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;centrosome#GO:0005813;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;intraciliary transport particle B#GO:0030992;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intraciliary transport particle#GO:0030990;intracellular organelle#GO:0043229;cilium#GO:0005929 HUMAN|HGNC=30689|UniProtKB=O75155 O75155 CAND2 PTHR12696:SF2 TIP120 CULLIN-ASSOCIATED NEDD8-DISSOCIATED PROTEIN 2 cellular process#GO:0009987;cellular component biogenesis#GO:0044085;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;cellular component assembly#GO:0022607;metabolic process#GO:0008152;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein modification by small protein conjugation#GO:0032446;protein-containing complex assembly#GO:0065003;protein modification process#GO:0036211;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;protein modification by small protein conjugation or removal#GO:0070647;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=26571|UniProtKB=Q5XG99 Q5XG99 LYSMD4 PTHR20932:SF7 LYSM AND PUTATIVE PEPTIDOGLYCAN-BINDING DOMAIN-CONTAINING PROTEIN AND PUTATIVE PEPTIDOGLYCAN-BINDING DOMAIN-CONTAINING PROTEIN 4-RELATED HUMAN|HGNC=5261|UniProtKB=P10809 P10809 HSPD1 PTHR45633:SF17 60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL 60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL protein binding#GO:0005515;protein-folding chaperone binding#GO:0051087;binding#GO:0005488 organelle organization#GO:0006996;positive regulation of immune system process#GO:0002684;establishment of localization in cell#GO:0051649;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;lymphocyte activation#GO:0046649;gene expression#GO:0010467;protein maturation#GO:0051604;cellular component organization or biogenesis#GO:0071840;regulation of biological process#GO:0050789;positive regulation of multicellular organismal process#GO:0051240;apoptotic process#GO:0006915;response to stimulus#GO:0050896;mitochondrial transport#GO:0006839;response to topologically incorrect protein#GO:0035966;protein folding#GO:0006457;immune system process#GO:0002376;positive regulation of macromolecule biosynthetic process#GO:0010557;cellular localization#GO:0051641;regulation of cytokine production#GO:0001817;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;macromolecule biosynthetic process#GO:0009059;regulation of cell adhesion#GO:0030155;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;positive regulation of leukocyte cell-cell adhesion#GO:1903039;biosynthetic process#GO:0009058;positive regulation of cell activation#GO:0050867;intracellular transport#GO:0046907;transport#GO:0006810;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;programmed cell death#GO:0012501;positive regulation of type I interferon production#GO:0032481;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of cell-cell adhesion#GO:0022407;cellular response to topologically incorrect protein#GO:0035967;positive regulation of lymphocyte activation#GO:0051251;positive regulation of cell-cell adhesion#GO:0022409;response to stress#GO:0006950;positive regulation of T cell activation#GO:0050870;regulation of T cell activation#GO:0050863;mitochondrion organization#GO:0007005;apoptotic mitochondrial changes#GO:0008637;regulation of multicellular organismal process#GO:0051239;metabolic process#GO:0008152;positive regulation of leukocyte activation#GO:0002696;regulation of leukocyte activation#GO:0002694;T cell activation#GO:0042110;cellular component organization#GO:0016043;regulation of cell activation#GO:0050865;regulation of lymphocyte activation#GO:0051249;cellular response to stress#GO:0033554;response to unfolded protein#GO:0006986;positive regulation of metabolic process#GO:0009893;regulation of macromolecule biosynthetic process#GO:0010556;mitochondrial protein import pathway#GO:7770058;regulation of leukocyte cell-cell adhesion#GO:1903037;establishment of localization#GO:0051234;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;leukocyte activation#GO:0045321;cell death#GO:0008219;positive regulation of cell adhesion#GO:0045785;positive regulation of cytokine production#GO:0001819;cellular response to unfolded protein#GO:0034620;cell activation#GO:0001775;positive regulation of biosynthetic process#GO:0009891;localization#GO:0051179;protein metabolic process#GO:0019538 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;organelle envelope#GO:0031967;organelle lumen#GO:0043233;organelle membrane#GO:0031090;cytoplasm#GO:0005737;mitochondrial membrane#GO:0031966;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;mitochondrial inner membrane#GO:0005743;membrane-enclosed lumen#GO:0031974;membrane#GO:0016020 HUMAN|HGNC=8667|UniProtKB=Q9Y5I0 Q9Y5I0 PCDHA13 PTHR24028:SF101 CADHERIN-87A PROTOCADHERIN ALPHA-13 cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 cell adhesion molecule#PC00069;cadherin#PC00057 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HUMAN|HGNC=27193|UniProtKB=Q17R98 Q17R98 ZNF827 PTHR24403:SF62 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 827 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;chromatin remodeling#GO:0006338;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;chromatin organization#GO:0006325;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=9962|UniProtKB=Q92900 Q92900 UPF1 PTHR10887:SF364 DNA2/NAM7 HELICASE FAMILY REGULATOR OF NONSENSE TRANSCRIPTS 1 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;ATP-dependent activity#GO:0140657;helicase activity#GO:0004386;isomerase activity#GO:0016853;catalytic activity, acting on RNA#GO:0140098;RNA helicase activity#GO:0003724;nucleic acid conformation isomerase activity#GO:0120545;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;macromolecular conformation isomerase activity#GO:0120543 macromolecule metabolic process#GO:0043170;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;negative regulation of cellular process#GO:0048523;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay#GO:0000184;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;mRNA catabolic process#GO:0006402;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleobase-containing compound catabolic process#GO:0034655;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;nucleic acid catabolic process#GO:0141188;cellular process#GO:0009987;RNA metabolic process#GO:0016070;RNA catabolic process#GO:0006401;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 RNA helicase#PC00032 HUMAN|HGNC=28051|UniProtKB=Q5TID7 Q5TID7 CCDC181 PTHR14320:SF2 COILED-COIL DOMAIN-CONTAINING PROTEIN 181 COILED-COIL DOMAIN-CONTAINING PROTEIN 181 tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;microtubule binding#GO:0008017;protein binding#GO:0005515 HUMAN|HGNC=29666|UniProtKB=Q96DP5 Q96DP5 MTFMT PTHR11138:SF5 METHIONYL-TRNA FORMYLTRANSFERASE METHIONYL-TRNA FORMYLTRANSFERASE, MITOCHONDRIAL catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring one-carbon groups#GO:0016741 nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;RNA biosynthetic process#GO:0032774;tRNA modification#GO:0006400;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;macromolecule modification#GO:0043412;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA modification#GO:0009451 mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 RNA processing factor#PC00147;RNA metabolism protein#PC00031 HUMAN|HGNC=14629|UniProtKB=Q53HL2 Q53HL2 CDCA8 PTHR16040:SF6 AUSTRALIN, ISOFORM A-RELATED BOREALIN cellular component organization#GO:0016043;sister chromatid segregation#GO:0000819;nuclear chromosome segregation#GO:0098813;cell cycle#GO:0007049;mitotic nuclear division#GO:0140014;cell cycle process#GO:0022402;mitotic metaphase chromosome alignment#GO:0007080;mitotic cell cycle#GO:0000278;nuclear division#GO:0000280;organelle localization#GO:0051640;organelle fission#GO:0048285;localization#GO:0051179;organelle organization#GO:0006996;mitotic sister chromatid segregation#GO:0000070;cellular process#GO:0009987;chromosome localization#GO:0050000;metaphase chromosome alignment#GO:0051310;chromosome segregation#GO:0007059;cellular component organization or biogenesis#GO:0071840;chromosome organization#GO:0051276;mitotic cell cycle process#GO:1903047 protein-containing complex#GO:0032991;microtubule associated complex#GO:0005875;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;spindle midzone#GO:0051233;chromosome, centromeric region#GO:0000775;cytoskeleton#GO:0005856;spindle#GO:0005819;intracellular organelle#GO:0043229 HUMAN|HGNC=535|UniProtKB=P50995 P50995 ANXA11 PTHR10502:SF29 ANNEXIN ANNEXIN A11 lipid binding#GO:0008289;phosphatidylserine binding#GO:0001786;anion binding#GO:0043168;small molecule binding#GO:0036094;binding#GO:0005488;phospholipid binding#GO:0005543;ion binding#GO:0043167 transport#GO:0006810;cytokinetic process#GO:0032506;phagocytosis#GO:0006909;cytokinesis#GO:0000910;import into cell#GO:0098657;establishment of localization#GO:0051234;localization#GO:0051179;cell division#GO:0051301;cell cycle process#GO:0022402;cellular process#GO:0009987;cell cycle#GO:0007049;endocytosis#GO:0006897 intracellular organelle#GO:0043229;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cell periphery#GO:0071944;vesicle#GO:0031982;membrane#GO:0016020;vesicle membrane#GO:0012506;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;organelle#GO:0043226 calcium-binding protein#PC00060 HUMAN|HGNC=39552|UniProtKB=Q5W188 Q5W188 CST9LP1 PTHR46945:SF2 CYSTATIN-9-LIKE CYSTATIN-9-LIKE PROTEIN CST9LP1-RELATED response to stimulus#GO:0050896;defense response to other organism#GO:0098542;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to other organism#GO:0051707;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;immune response#GO:0006955;defense response to symbiont#GO:0140546;response to external stimulus#GO:0009605;defense response#GO:0006952;immune system process#GO:0002376;antimicrobial humoral response#GO:0019730;humoral immune response#GO:0006959 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=21245|UniProtKB=Q6UXB8 Q6UXB8 PI16 PTHR10334:SF613 CYSTEINE-RICH SECRETORY PROTEIN-RELATED PEPTIDASE INHIBITOR 16 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 defense/immunity protein#PC00090 HUMAN|HGNC=5044|UniProtKB=P61978 P61978 HNRNPK PTHR10288:SF331 KH DOMAIN CONTAINING RNA BINDING PROTEIN HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN K mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of mRNA processing#GO:0050684;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of mRNA metabolic process#GO:1903311;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 RNA metabolism protein#PC00031 HUMAN|HGNC=1054|UniProtKB=Q9NQY0 Q9NQY0 BIN3 PTHR47174:SF3 BRIDGING INTEGRATOR 3 BRIDGING INTEGRATOR 3 lipid binding#GO:0008289;binding#GO:0005488 endomembrane system organization#GO:0010256;membrane organization#GO:0061024;endocytosis#GO:0006897;cellular process#GO:0009987;cellular component organization#GO:0016043;import into cell#GO:0098657;establishment of localization#GO:0051234;plasma membrane organization#GO:0007009;cellular component organization or biogenesis#GO:0071840;localization#GO:0051179;transport#GO:0006810 actin cytoskeleton#GO:0015629;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=14352|UniProtKB=Q9H1Z4 Q9H1Z4 WDR13 PTHR22838:SF4 WD REPEAT PROTEIN 26-RELATED WD REPEAT-CONTAINING PROTEIN 13 binding#GO:0005488;chromatin binding#GO:0003682 HUMAN|HGNC=13081|UniProtKB=Q9BY12 Q9BY12 SCAPER PTHR31434:SF2 S PHASE CYCLIN A-ASSOCIATED PROTEIN IN THE ENDOPLASMIC RETICULUM S PHASE CYCLIN A-ASSOCIATED PROTEIN IN THE ENDOPLASMIC RETICULUM HUMAN|HGNC=1603|UniProtKB=P41597 P41597 CCR2 PTHR10489:SF913 CELL ADHESION MOLECULE C-C CHEMOKINE RECEPTOR TYPE 2 immune receptor activity#GO:0140375;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;cytokine binding#GO:0019955;cytokine receptor activity#GO:0004896;molecular transducer activity#GO:0060089;protein binding#GO:0005515;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888 response to stress#GO:0006950;cellular process#GO:0009987;signal transduction#GO:0007165;immune response#GO:0006955;cell migration#GO:0016477;taxis#GO:0042330;response to chemical#GO:0042221;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;calcium-mediated signaling#GO:0019722;defense response#GO:0006952;response to external stimulus#GO:0009605;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cell motility#GO:0048870;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;locomotion#GO:0040011;signaling#GO:0023052;cellular response to chemical stimulus#GO:0070887;immune system process#GO:0002376;positive regulation of cytosolic calcium ion concentration#GO:0007204;chemotaxis#GO:0006935;inflammatory response#GO:0006954;cell communication#GO:0007154;regulation of biological quality#GO:0065008;intracellular signal transduction#GO:0035556;cell chemotaxis#GO:0060326 cell surface#GO:0009986;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cytoplasm#GO:0005737;membrane#GO:0016020;cell periphery#GO:0071944;side of membrane#GO:0098552;intracellular anatomical structure#GO:0005622;external side of plasma membrane#GO:0009897 cell adhesion molecule#PC00069 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CHKR#P00854 HUMAN|HGNC=24613|UniProtKB=Q86YC3 Q86YC3 NRROS PTHR45617:SF7 LEUCINE RICH REPEAT FAMILY PROTEIN TRANSFORMING GROWTH FACTOR BETA ACTIVATOR LRRC33 growth factor binding#GO:0019838;protein binding#GO:0005515;cytokine binding#GO:0019955;binding#GO:0005488;transforming growth factor beta binding#GO:0050431 response to stress#GO:0006950;immune system process#GO:0002376;immune response#GO:0006955;inflammatory response#GO:0006954;response to stimulus#GO:0050896;defense response#GO:0006952 cell surface#GO:0009986;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=16088|UniProtKB=Q6P4A7 Q6P4A7 SFXN4 PTHR11153:SF3 SIDEROFLEXIN SIDEROFLEXIN-4 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 transport#GO:0006810;mitochondrial transmembrane transport#GO:1990542;intracellular transport#GO:0046907;cellular localization#GO:0051641;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;localization#GO:0051179;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;mitochondrial transport#GO:0006839 membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740 primary active transporter#PC00068 HUMAN|HGNC=8794|UniProtKB=O95263 O95263 PDE8B PTHR11347:SF98 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE HIGH AFFINITY CAMP-SPECIFIC AND IBMX-INSENSITIVE 3',5'-CYCLIC PHOSPHODIESTERASE 8B hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;cyclic-nucleotide phosphodiesterase activity#GO:0004112;phosphoric diester hydrolase activity#GO:0008081;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578 positive regulation of MAPK cascade#GO:0043410;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;regulation of MAPK cascade#GO:0043408;negative regulation of cellular process#GO:0048523;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of response to stimulus#GO:0048585;regulation of ERK1 and ERK2 cascade#GO:0070372;positive regulation of response to stimulus#GO:0048584;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;positive regulation of ERK1 and ERK2 cascade#GO:0070374;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;positive regulation of signal transduction#GO:0009967 hydrolase#PC00121;phosphodiesterase#PC00185 HUMAN|HGNC=9327|UniProtKB=P01298 P01298 PPY PTHR10533:SF2 NEUROPEPTIDE Y/PANCREATIC HORMONE/PEPTIDE YY PANCREATIC POLYPEPTIDE PROHORMONE signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515;hormone activity#GO:0005179;molecular function activator activity#GO:0140677;signaling receptor regulator activity#GO:0030545;neuropeptide receptor binding#GO:0071855;receptor ligand activity#GO:0048018;G protein-coupled receptor binding#GO:0001664;neuropeptide hormone activity#GO:0005184;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772 cell communication#GO:0007154;feeding behavior#GO:0007631;G protein-coupled receptor signaling pathway#GO:0007186;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;multicellular organismal process#GO:0032501;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;neuropeptide signaling pathway#GO:0007218 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HUMAN|HGNC=7957|UniProtKB=P49146 P49146 NPY2R PTHR24235:SF20 NEUROPEPTIDE Y RECEPTOR NEUROPEPTIDE Y RECEPTOR TYPE 2 G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888;neuropeptide receptor activity#GO:0008188;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;neuropeptide signaling pathway#GO:0007218;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052 cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;membrane-bounded organelle#GO:0043227;cilium#GO:0005929 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=104|UniProtKB=Q8NE01 Q8NE01 CNNM3 PTHR12064:SF27 METAL TRANSPORTER CNNM METAL TRANSPORTER CNNM3 transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 monoatomic ion homeostasis#GO:0050801;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;inorganic ion homeostasis#GO:0098771;homeostatic process#GO:0042592 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 ion channel#PC00133;transporter#PC00227 HUMAN|HGNC=16703|UniProtKB=Q9P2U8 Q9P2U8 SLC17A6 PTHR11662:SF201 SOLUTE CARRIER FAMILY 17 VESICULAR GLUTAMATE TRANSPORTER 2 carboxylic acid transmembrane transporter activity#GO:0046943;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;amino acid transmembrane transporter activity#GO:0015171;acidic amino acid transmembrane transporter activity#GO:0015172;L-amino acid transmembrane transporter activity#GO:0015179;L-glutamate transmembrane transporter activity#GO:0005313;dicarboxylic acid transmembrane transporter activity#GO:0005310 anterograde trans-synaptic signaling#GO:0098916;signaling#GO:0023052;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;localization#GO:0051179;cell communication#GO:0007154;cellular localization#GO:0051641;regulation of synapse structure or activity#GO:0050803;regulation of biological quality#GO:0065008;trans-synaptic signaling#GO:0099537;vesicle-mediated transport#GO:0016192;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;neurotransmitter transport#GO:0006836;synaptic transmission, glutamatergic#GO:0035249;synaptic signaling#GO:0099536;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;establishment of localization#GO:0051234;vesicle-mediated transport in synapse#GO:0099003;synaptic vesicle cycle#GO:0099504;transport#GO:0006810 intracellular vesicle#GO:0097708;synaptic vesicle membrane#GO:0030672;vesicle#GO:0031982;synaptic vesicle#GO:0008021;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;vesicle membrane#GO:0012506;secretory vesicle#GO:0099503;membrane#GO:0016020;presynapse#GO:0098793;transport vesicle#GO:0030133;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;transport vesicle membrane#GO:0030658;cytoplasm#GO:0005737;cell junction#GO:0030054;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090 secondary carrier transporter#PC00258 Ionotropic glutamate receptor pathway#P00037>Vglut#P01021 HUMAN|HGNC=6240|UniProtKB=P15382 P15382 KCNE1 PTHR15282:SF10 POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY E MEMBER 1, 3 POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY E MEMBER 1 monoatomic cation channel activity#GO:0005261;molecular function regulator activity#GO:0098772;ion channel regulator activity#GO:0099106;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;channel regulator activity#GO:0016247;transporter regulator activity#GO:0141108;potassium channel activity#GO:0005267;transmembrane transporter binding#GO:0044325;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;transporter activity#GO:0005215;voltage-gated channel activity#GO:0022832;protein binding#GO:0005515;monoatomic cation transmembrane transporter activity#GO:0008324;binding#GO:0005488;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;potassium channel regulator activity#GO:0015459;voltage-gated potassium channel activity#GO:0005249 export from cell#GO:0140352;regulation of biological process#GO:0050789;action potential#GO:0001508;muscle system process#GO:0003012;heart process#GO:0003015;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;cardiac muscle cell action potential involved in contraction#GO:0086002;monoatomic cation transmembrane transport#GO:0098655;regulation of multicellular organismal process#GO:0051239;cellular process#GO:0009987;regulation of membrane potential#GO:0042391;actin-mediated cell contraction#GO:0070252;striated muscle contraction#GO:0006941;metal ion transport#GO:0030001;regulation of heart contraction#GO:0008016;monoatomic cation transport#GO:0006812;localization#GO:0051179;circulatory system process#GO:0003013;cardiac muscle contraction#GO:0060048;actin filament-based process#GO:0030029;potassium ion transport#GO:0006813;blood circulation#GO:0008015;multicellular organismal process#GO:0032501;potassium ion transmembrane transport#GO:0071805;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;actin filament-based movement#GO:0030048;cardiac muscle cell contraction#GO:0086003;establishment of localization#GO:0051234;system process#GO:0003008;heart contraction#GO:0060047;regulation of system process#GO:0044057;muscle contraction#GO:0006936;transport#GO:0006810 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane#GO:0016020;membrane protein complex#GO:0098796;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703 voltage-gated ion channel#PC00241 HUMAN|HGNC=30489|UniProtKB=P0C7X2 P0C7X2 ZNF688 PTHR23232:SF69 KRAB DOMAIN C2H2 ZINC FINGER ZINC FINGER PROTEIN 688 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=16495|UniProtKB=Q9NRY6 Q9NRY6 PLSCR3 PTHR23248:SF37 PHOSPHOLIPID SCRAMBLASE-RELATED PHOSPHOLIPID SCRAMBLASE 3 intramembrane lipid carrier activity#GO:0140303;transporter activity#GO:0005215;phospholipid scramblase activity#GO:0017128;molecular carrier activity#GO:0140104;lipid carrier activity#GO:0005319 lipid localization#GO:0010876;regulation of release of cytochrome c from mitochondria#GO:0090199;plasma membrane organization#GO:0007009;localization#GO:0051179;regulation of biological quality#GO:0065008;programmed cell death#GO:0012501;cellular component organization#GO:0016043;regulation of mitochondrion organization#GO:0010821;regulation of biological process#GO:0050789;cell death#GO:0008219;apoptotic process#GO:0006915;regulation of organelle organization#GO:0033043;organophosphate ester transport#GO:0015748;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;plasma membrane phospholipid scrambling#GO:0017121;lipid translocation#GO:0034204;transport#GO:0006810;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;regulation of membrane lipid distribution#GO:0097035;macromolecule localization#GO:0033036;cellular process#GO:0009987;lipid transport#GO:0006869;endomembrane system organization#GO:0010256;phospholipid translocation#GO:0045332;phospholipid transport#GO:0015914;biological regulation#GO:0065007;membrane organization#GO:0061024 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transporter#PC00227 HUMAN|HGNC=14415|UniProtKB=Q9GZR5 Q9GZR5 ELOVL4 PTHR11157:SF126 FATTY ACID ACYL TRANSFERASE-RELATED VERY LONG CHAIN FATTY ACID ELONGASE 4 acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746 oxoacid metabolic process#GO:0043436;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;carboxylic acid biosynthetic process#GO:0046394;small molecule metabolic process#GO:0044281;very long-chain fatty acid metabolic process#GO:0000038;metabolic process#GO:0008152;sphingolipid metabolic process#GO:0006665;sphingolipid biosynthetic process#GO:0030148;fatty acid metabolic process#GO:0006631;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;monocarboxylic acid biosynthetic process#GO:0072330;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058;fatty acid biosynthetic process#GO:0006633 membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;membrane#GO:0016020 acyltransferase#PC00042;transferase#PC00220 HUMAN|HGNC=6038|UniProtKB=Q12906 Q12906 ILF3 PTHR45762:SF4 ZINC FINGER RNA-BINDING PROTEIN INTERLEUKIN ENHANCER-BINDING FACTOR 3 single-stranded RNA binding#GO:0003727;RNA binding#GO:0003723;double-stranded RNA binding#GO:0003725;nucleic acid binding#GO:0003676;binding#GO:0005488 RNA metabolism protein#PC00031 HUMAN|HGNC=2696|UniProtKB=Q9UJU6 Q9UJU6 DBNL PTHR10829:SF12 CORTACTIN AND DREBRIN DREBRIN-LIKE PROTEIN binding#GO:0005488;actin filament binding#GO:0051015;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;protein-containing complex binding#GO:0044877 regulation of actin filament length#GO:0030832;regulation of biological quality#GO:0065008;cellular component organization#GO:0016043;regulation of protein-containing complex assembly#GO:0043254;regulation of supramolecular fiber organization#GO:1902903;regulation of cellular component size#GO:0032535;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;regulation of cytoskeleton organization#GO:0051493;regulation of protein polymerization#GO:0032271;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of cellular component biogenesis#GO:0044087;regulation of anatomical structure size#GO:0090066;regulation of actin filament-based process#GO:0032970;cellular component organization or biogenesis#GO:0071840;regulation of actin filament organization#GO:0110053;cellular process#GO:0009987;regulation of actin filament polymerization#GO:0030833;biological regulation#GO:0065007;regulation of actin polymerization or depolymerization#GO:0008064;regulation of actin cytoskeleton organization#GO:0032956 intracellular organelle#GO:0043229;dendritic tree#GO:0097447;dendrite#GO:0030425;supramolecular fiber#GO:0099512;site of polarized growth#GO:0030427;intracellular anatomical structure#GO:0005622;cell cortex#GO:0005938;actin cytoskeleton#GO:0015629;cortical cytoskeleton#GO:0030863;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;actin filament#GO:0005884;cytoskeleton#GO:0005856;cell junction#GO:0030054;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;neuron projection#GO:0043005;cell periphery#GO:0071944;cell leading edge#GO:0031252;intracellular membraneless organelle#GO:0043232;somatodendritic compartment#GO:0036477;cortical actin cytoskeleton#GO:0030864;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;lamellipodium#GO:0030027;supramolecular polymer#GO:0099081;glutamatergic synapse#GO:0098978 cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HUMAN|HGNC=12537|UniProtKB=P35504 P35504 UGT1A5 PTHR48050:SF12 STEROL 3-BETA-GLUCOSYLTRANSFERASE UDP-GLUCURONOSYLTRANSFERASE 1A3-RELATED enzyme inhibitor activity#GO:0004857;catalytic activity#GO:0003824;transferase activity#GO:0016740;molecular function regulator activity#GO:0098772;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;enzyme binding#GO:0019899;binding#GO:0005488;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;protein binding#GO:0005515 response to endogenous stimulus#GO:0009719;regulation of hormone levels#GO:0010817;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;liver development#GO:0001889;cellular response to hormone stimulus#GO:0032870;cellular response to chemical stimulus#GO:0070887;animal gross anatomical part developmental process#GO:0160108;estrogen metabolic process#GO:0008210;regulation of biological quality#GO:0065008;response to hormone#GO:0009725;cellular process#GO:0009987;response to chemical#GO:0042221;cellular response to lipid#GO:0071396;response to lipid#GO:0033993;steroid metabolic process#GO:0008202;metabolic process#GO:0008152;multicellular organism development#GO:0007275;cellular response to steroid hormone stimulus#GO:0071383;animal organ development#GO:0048513;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;response to steroid hormone#GO:0048545;anatomical structure development#GO:0048856;system development#GO:0048731;pigment metabolic process#GO:0042440;hormone metabolic process#GO:0042445;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;developmental process#GO:0032502;lipid metabolic process#GO:0006629;sterol metabolic process#GO:0016125 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 glycosyltransferase#PC00111;transferase#PC00220 Nicotine degradation#P05914>UGT1A4#P05982 HUMAN|HGNC=23703|UniProtKB=Q7Z2K6 Q7Z2K6 ERMP1 PTHR12147:SF22 METALLOPEPTIDASE M28 FAMILY MEMBER ENDOPLASMIC RETICULUM METALLOPEPTIDASE 1 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;proteolysis#GO:0006508;metabolic process#GO:0008152;cellular process#GO:0009987 protease#PC00190;metalloprotease#PC00153 HUMAN|HGNC=30490|UniProtKB=Q7Z309 Q7Z309 PABIR2 PTHR22227:SF1 FAMILY WITH SEQUENCE SIMILARITY 122B ISOFORM X1 PABIR FAMILY MEMBER 2 protein phosphatase inhibitor activity#GO:0004864;enzyme inhibitor activity#GO:0004857;phosphatase regulator activity#GO:0019208;molecular function regulator activity#GO:0098772;phosphatase inhibitor activity#GO:0019212;protein serine/threonine phosphatase inhibitor activity#GO:0004865;enzyme regulator activity#GO:0030234;protein phosphatase regulator activity#GO:0019888;molecular function inhibitor activity#GO:0140678 regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;positive regulation of ubiquitin-dependent protein catabolic process#GO:2000060;positive regulation of proteasomal protein catabolic process#GO:1901800;positive regulation of protein catabolic process#GO:0045732;regulation of protein catabolic process#GO:0042176;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434;positive regulation of metabolic process#GO:0009893;positive regulation of protein metabolic process#GO:0051247;positive regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032436;biological regulation#GO:0065007;positive regulation of macromolecule metabolic process#GO:0010604;regulation of proteasomal protein catabolic process#GO:0061136;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;regulation of catabolic process#GO:0009894;positive regulation of catabolic process#GO:0009896;regulation of ubiquitin-dependent protein catabolic process#GO:2000058 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=27397|UniProtKB=Q5JQC4 Q5JQC4 CT47A1 PTHR32157:SF8 GENE 6268-RELATED CANCER_TESTIS ANTIGEN 47A HUMAN|HGNC=1459|UniProtKB=Q14012 Q14012 CAMK1 PTHR24347:SF197 SERINE/THREONINE-PROTEIN KINASE CALCIUM_CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 1 kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;calmodulin binding#GO:0005516;catalytic activity, acting on a protein#GO:0140096;calcium/calmodulin-dependent protein kinase activity#GO:0004683;binding#GO:0005488;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein binding#GO:0005515 signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of biological quality#GO:0065008;regulation of localization#GO:0032879;regulation of protein localization#GO:0032880;regulation of synapse structure or activity#GO:0050803;cell communication#GO:0007154;regulation of synapse organization#GO:0050807 synapse#GO:0045202;cellular anatomical structure#GO:0110165;neuron to neuron synapse#GO:0098984;asymmetric synapse#GO:0032279;postsynaptic specialization#GO:0099572;organelle#GO:0043226;cytoplasm#GO:0005737;postsynapse#GO:0098794;cell junction#GO:0030054;intracellular anatomical structure#GO:0005622;postsynaptic density#GO:0014069 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=10840|UniProtKB=P29353 P29353 SHC1 PTHR10337:SF2 SHC TRANSFORMING PROTEIN SHC-TRANSFORMING PROTEIN 1 enzyme binding#GO:0019899;transmembrane receptor protein tyrosine kinase adaptor activity#GO:0005068;protein kinase binding#GO:0019901;kinase binding#GO:0019900;binding#GO:0005488;protein tyrosine kinase binding#GO:1990782;signaling receptor binding#GO:0005102;protein-macromolecule adaptor activity#GO:0030674;signaling adaptor activity#GO:0035591;protein binding#GO:0005515;receptor tyrosine kinase binding#GO:0030971;signaling receptor complex adaptor activity#GO:0030159;molecular adaptor activity#GO:0060090 signaling#GO:0023052;cellular response to hormone stimulus#GO:0032870;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;positive regulation of cell population proliferation#GO:0008284;response to endogenous stimulus#GO:0009719;response to oxygen-containing compound#GO:1901700;insulin receptor signaling pathway#GO:0008286;cellular response to chemical stimulus#GO:0070887;response to chemical#GO:0042221;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;response to hormone#GO:0009725;cell surface receptor signaling pathway#GO:0007166;cellular response to peptide hormone stimulus#GO:0071375;regulation of cellular process#GO:0050794;response to insulin#GO:0032868;cellular response to stimulus#GO:0051716;response to nitrogen compound#GO:1901698;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;response to peptide hormone#GO:0043434;biological regulation#GO:0065007;epidermal growth factor receptor signaling pathway#GO:0007173;cellular response to nitrogen compound#GO:1901699;ERBB signaling pathway#GO:0038127;positive regulation of cellular process#GO:0048522;cellular response to insulin stimulus#GO:0032869 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944 scaffold/adaptor protein#PC00226 Angiogenesis#P00005>Shc#P00183;CCKR signaling map#P06959>SHC1 @EGFR#P07083;FGF signaling pathway#P00021>Shc#P00639;CCKR signaling map#P06959>p52 SHC1#P07151;Integrin signalling pathway#P00034>Shc#P00949;Ras Pathway#P04393>Shc#P04579;PDGF signaling pathway#P00047>Shc#P01175;CCKR signaling map#P06959>p66 SHC1#P07168;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Shc#P00865;Interleukin signaling pathway#P00036>Shc#P00997;CCKR signaling map#P06959>SHC1#P07138;CCKR signaling map#P06959>p46 SHC1#P07098;EGF receptor signaling pathway#P00018>Shc#P00554 HUMAN|HGNC=8101|UniProtKB=Q04671 Q04671 OCA2 PTHR43568:SF2 P PROTEIN P PROTEIN phenol-containing compound metabolic process#GO:0018958;cell differentiation#GO:0030154;pigmentation#GO:0043473;melanin biosynthetic process#GO:0042438;pigment metabolic process#GO:0042440;phenol-containing compound biosynthetic process#GO:0046189;cellular process#GO:0009987;developmental pigmentation#GO:0048066;melanocyte differentiation#GO:0030318;biosynthetic process#GO:0009058;secondary metabolite biosynthetic process#GO:0044550;metabolic process#GO:0008152;pigment biosynthetic process#GO:0046148;developmental process#GO:0032502;cellular developmental process#GO:0048869;secondary metabolic process#GO:0019748 cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;cytoplasmic vesicle membrane#GO:0030659;melanosome#GO:0042470;cytoplasm#GO:0005737;membrane#GO:0016020;vesicle membrane#GO:0012506 transporter#PC00227;primary active transporter#PC00068 HUMAN|HGNC=23597|UniProtKB=Q701N4 Q701N4 KRTAP5-2 PTHR23262:SF218 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 5-10-RELATED structural protein#PC00211 HUMAN|HGNC=9305|UniProtKB=Q00005 Q00005 PPP2R2B PTHR11871:SF1 PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B BETA ISOFORM protein phosphatase regulator activity#GO:0019888;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;phosphatase regulator activity#GO:0019208 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829;protein serine/threonine phosphatase complex#GO:0008287;catalytic complex#GO:1902494 protein modifying enzyme#PC00260;protein phosphatase#PC00195 FGF signaling pathway#P00021>PP2A#P00629 HUMAN|HGNC=11831|UniProtKB=O00142 O00142 TK2 PTHR10513:SF24 DEOXYNUCLEOSIDE KINASE THYMIDINE KINASE 2, MITOCHONDRIAL transferase activity#GO:0016740;catalytic activity#GO:0003824;nucleobase-containing compound kinase activity#GO:0019205;deoxynucleoside kinase activity#GO:0019136;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 metabolite interconversion enzyme#PC00262;nucleotide kinase#PC00172 HUMAN|HGNC=21606|UniProtKB=Q9Y5U8 Q9Y5U8 MPC1 PTHR14154:SF8 UPF0041 BRAIN PROTEIN 44-RELATED MITOCHONDRIAL PYRUVATE CARRIER 1 carboxylic acid transmembrane transporter activity#GO:0046943;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monocarboxylic acid transmembrane transporter activity#GO:0008028 monocarboxylic acid transport#GO:0015718;localization#GO:0051179;cellular localization#GO:0051641;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;mitochondrial transmembrane transport#GO:1990542;organic acid transport#GO:0015849;transport#GO:0006810;carboxylic acid transport#GO:0046942;intracellular transport#GO:0046907;carboxylic acid transmembrane transport#GO:1905039;mitochondrial transport#GO:0006839;establishment of localization in cell#GO:0051649;cellular process#GO:0009987 mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrial inner membrane#GO:0005743;organelle envelope#GO:0031967;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090 HUMAN|HGNC=30744|UniProtKB=P0CG34 P0CG34 TMSB15A PTHR12021:SF11 THYMOSIN BETA THYMOSIN BETA-15A-RELATED molecular sequestering activity#GO:0140313;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;protein sequestering activity#GO:0140311;actin binding#GO:0003779;actin monomer binding#GO:0003785;protein binding#GO:0005515 regulation of cellular process#GO:0050794;regulation of cell motility#GO:2000145;regulation of locomotion#GO:0040012;biological regulation#GO:0065007;regulation of biological process#GO:0050789;regulation of cell migration#GO:0030334 actin filament#GO:0005884;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;actin cytoskeleton#GO:0015629;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;supramolecular complex#GO:0099080;organelle#GO:0043226 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=21064|UniProtKB=Q64LD2 Q64LD2 WDR25 PTHR44566:SF1 TRANSDUCIN/WD40 REPEAT-LIKE SUPERFAMILY PROTEIN WD REPEAT-CONTAINING PROTEIN 25 HUMAN|HGNC=18747|UniProtKB=Q9C0A0 Q9C0A0 CNTNAP4 PTHR15036:SF40 PIKACHURIN-LIKE PROTEIN CONTACTIN-ASSOCIATED PROTEIN-LIKE 4 developmental process#GO:0032502;multicellular organism development#GO:0007275;cellular process#GO:0009987;signal transduction#GO:0007165;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;biological regulation#GO:0065007;animal gross anatomical part developmental process#GO:0160108;anatomical structure development#GO:0048856;cell communication#GO:0007154;system development#GO:0048731;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052 synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell junction#GO:0030054;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 cell adhesion molecule#PC00069 HUMAN|HGNC=9848|UniProtKB=P49792 P49792 RANBP2 PTHR23138:SF175 RAN BINDING PROTEIN E3 SUMO-PROTEIN LIGASE RANBP2-RELATED aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;SUMO transferase activity#GO:0019789;ubiquitin-like protein transferase activity#GO:0019787;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746 establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810;protein localization to nucleus#GO:0034504;macromolecule localization#GO:0033036;import into nucleus#GO:0051170;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular localization#GO:0051641;localization#GO:0051179;NLS-bearing protein import into nucleus#GO:0006607;protein transport#GO:0015031;protein import into nucleus#GO:0006606;nuclear export#GO:0051168;nuclear transport#GO:0051169;nucleocytoplasmic transport#GO:0006913;protein localization to organelle#GO:0033365 nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;nuclear pore#GO:0005643;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;nucleus#GO:0005634 scaffold/adaptor protein#PC00226 HUMAN|HGNC=12915|UniProtKB=P52739 P52739 ZNF131 PTHR24399:SF35 ZINC FINGER AND BTB DOMAIN-CONTAINING ZINC FINGER PROTEIN 131 sequence-specific double-stranded DNA binding#GO:1990837;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;transcription cis-regulatory region binding#GO:0000976;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription repressor activity#GO:0001217;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulator activity#GO:0140110 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218 HUMAN|HGNC=30266|UniProtKB=Q96NA2 Q96NA2 RILP PTHR21502:SF7 ZINC FINGER PROTEIN DZIP1 RAB-INTERACTING LYSOSOMAL PROTEIN enzyme binding#GO:0019899;binding#GO:0005488;small GTPase binding#GO:0031267;protein binding#GO:0005515 organelle assembly#GO:0070925;cilium organization#GO:0044782;localization#GO:0051179;cellular localization#GO:0051641;cilium assembly#GO:0060271;cellular component organization#GO:0016043;cell projection organization#GO:0030030;transport#GO:0006810;plasma membrane bounded cell projection assembly#GO:0120031;intracellular transport#GO:0046907;endosomal transport#GO:0016197;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;establishment of localization in cell#GO:0051649;cell projection assembly#GO:0030031;cellular process#GO:0009987;early endosome to late endosome transport#GO:0045022;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;vesicle-mediated transport#GO:0016192 microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;ciliary basal body#GO:0036064;lytic vacuole#GO:0000323;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;vacuole#GO:0005773;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;cilium#GO:0005929;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;lysosome#GO:0005764;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;intracellular membrane-bounded organelle#GO:0043231 microtubule or microtubule-binding cytoskeletal protein#PC00157;cytoskeletal protein#PC00085;non-motor microtubule binding protein#PC00166 HUMAN|HGNC=11997|UniProtKB=Q9H497 Q9H497 TOR3A PTHR10760:SF3 TORSIN TORSIN-3A intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;organelle envelope#GO:0031967;endoplasmic reticulum#GO:0005783;endomembrane system#GO:0012505;cytoplasm#GO:0005737;nuclear envelope#GO:0005635;membrane-enclosed lumen#GO:0031974;endoplasmic reticulum lumen#GO:0005788;nucleus#GO:0005634 chaperone#PC00072 HUMAN|HGNC=23143|UniProtKB=Q8NB59 Q8NB59 SYT14 PTHR46129:SF3 SYNAPTOTAGMIN 14, ISOFORM D SYNAPTOTAGMIN-14 lipid binding#GO:0008289;phospholipid binding#GO:0005543;binding#GO:0005488 membrane trafficking regulatory protein#PC00151 HUMAN|HGNC=9563|UniProtKB=Q16401 Q16401 PSMD5 PTHR13554:SF10 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 5-RELATED 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 5 protease#PC00190 HUMAN|HGNC=29346|UniProtKB=Q9C0I9 Q9C0I9 LRRC27 PTHR16083:SF3 LEUCINE RICH REPEAT CONTAINING PROTEIN LEUCINE-RICH REPEAT-CONTAINING PROTEIN 27 scaffold/adaptor protein#PC00226 HUMAN|HGNC=20197|UniProtKB=Q96A29 Q96A29 SLC35C1 PTHR11132:SF255 SOLUTE CARRIER FAMILY 35 GDP-FUCOSE TRANSPORTER 1 antiporter activity#GO:0015297;secondary active transmembrane transporter activity#GO:0015291;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;active transmembrane transporter activity#GO:0022804;organophosphate ester transmembrane transporter activity#GO:0015605;nucleobase-containing compound transmembrane transporter activity#GO:0015932;carbohydrate derivative transmembrane transporter activity#GO:1901505;nucleotide-sugar transmembrane transporter activity#GO:0005338 nucleobase-containing compound transport#GO:0015931;organophosphate ester transport#GO:0015748;carbohydrate derivative transport#GO:1901264;cellular process#GO:0009987;nucleotide-sugar transmembrane transport#GO:0015780;nitrogen compound transport#GO:0071705;transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810 bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020 transporter#PC00227;secondary carrier transporter#PC00258 HUMAN|HGNC=23463|UniProtKB=Q5VTM2 Q5VTM2 AGAP9 PTHR45819:SF7 CENTAURIN-GAMMA-1A ARF-GAP WITH GTPASE, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 4-RELATED hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;enzyme activator activity#GO:0008047;catalytic activity#GO:0003824;molecular function regulator activity#GO:0098772;ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;molecular function activator activity#GO:0140677;hydrolase activity#GO:0016787;enzyme regulator activity#GO:0030234 GTPase-activating protein#PC00257;G-protein modulator#PC00022 HUMAN|HGNC=10886|UniProtKB=Q8IXJ6 Q8IXJ6 SIRT2 PTHR11085:SF6 NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2 deacylase activity#GO:0160215;transferase activity#GO:0016740;histone deacetylase activity#GO:0004407;catalytic activity#GO:0003824;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;catalytic activity, acting on a protein#GO:0140096;NAD-dependent protein lysine deacetylase activity#GO:0034979;acyltransferase activity#GO:0016746;histone modifying activity#GO:0140993;deacetylase activity#GO:0019213 negative regulation of gene expression, epigenetic#GO:0045814;regulation of biosynthetic process#GO:0009889;nucleus organization#GO:0006997;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;cellular component assembly#GO:0022607;heterochromatin organization#GO:0070828;chromatin organization#GO:0006325;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;epigenetic regulation of gene expression#GO:0040029;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;organelle organization#GO:0006996;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;nucleolus organization#GO:0007000;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;heterochromatin formation#GO:0031507 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=21870|UniProtKB=Q9NV12 Q9NV12 TMEM140 PTHR16103:SF0 TRANSMEMBRANE PROTEIN 140 TRANSMEMBRANE PROTEIN 140 HUMAN|HGNC=29123|UniProtKB=Q9Y4B4 Q9Y4B4 RAD54L2 PTHR45797:SF1 RAD54-LIKE HELICASE ARIP4 ATP-dependent activity, acting on DNA#GO:0008094;catalytic activity, acting on DNA#GO:0140097;catalytic activity#GO:0003824;transcription coregulator activity#GO:0003712;catalytic activity, acting on a nucleic acid#GO:0140640;transcription regulator activity#GO:0140110;ATP-dependent activity#GO:0140657 cellular process#GO:0009987;cellular component organization#GO:0016043;chromatin organization#GO:0006325;cellular component organization or biogenesis#GO:0071840 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=26715|UniProtKB=Q3B8N5 Q3B8N5 PROX2 PTHR12198:SF5 HOMEOBOX PROTEIN PROSPERO/PROX-1/CEH-26 PROSPERO HOMEOBOX PROTEIN 2 cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 HUMAN|HGNC=3179|UniProtKB=P25101 P25101 EDNRA PTHR46099:SF2 G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN ENDOTHELIN-1 RECEPTOR G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;peptide receptor activity#GO:0001653;signaling receptor activity#GO:0038023 system process#GO:0003008;regulation of anatomical structure size#GO:0090066;multicellular organismal process#GO:0032501;blood circulation#GO:0008015;biological regulation#GO:0065007;cellular process#GO:0009987;developmental pigmentation#GO:0048066;signal transduction#GO:0007165;cell communication#GO:0007154;regulation of biological quality#GO:0065008;circulatory system process#GO:0003013;G protein-coupled receptor signaling pathway#GO:0007186;pigmentation#GO:0043473;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 Endothelin signaling pathway#P00019>ET-RA/B#P00580 HUMAN|HGNC=2034|UniProtKB=P56749 P56749 CLDN12 PTHR16703:SF3 CLAUDIN-12 CLAUDIN-12 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HUMAN|HGNC=3592|UniProtKB=Q9Y285 Q9Y285 FARSA PTHR11538:SF40 PHENYLALANYL-TRNA SYNTHETASE PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;ligase activity#GO:0016874;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a tRNA#GO:0140101 translation#GO:0006412;RNA metabolic process#GO:0016070;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;protein biosynthetic process#GO:0160307;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;amino acid activation#GO:0043038;macromolecule metabolic process#GO:0043170;tRNA aminoacylation#GO:0043039;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;tRNA aminoacylation for protein translation#GO:0006418;gene expression#GO:0010467;amino acid metabolic process#GO:0006520;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494 aminoacyl-tRNA synthetase#PC00047 HUMAN|HGNC=20332|UniProtKB=Q9H1J1 Q9H1J1 UPF3A PTHR13112:SF2 UPF3 REGULATOR OF NONSENSE TRANSCRIPTS-LIKE PROTEIN REGULATOR OF NONSENSE TRANSCRIPTS 3A binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;telomeric repeat DNA binding#GO:0042162;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;RNA binding#GO:0003723 regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;RNA catabolic process#GO:0006401;positive regulation of protein metabolic process#GO:0051247;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;RNA metabolic process#GO:0016070;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;regulation of protein metabolic process#GO:0051246;positive regulation of macromolecule metabolic process#GO:0010604;nuclear-transcribed mRNA catabolic process, nonsense-mediated decay#GO:0000184;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of translation#GO:0045727;positive regulation of biosynthetic process#GO:0009891;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;nucleic acid catabolic process#GO:0141188;regulation of primary metabolic process#GO:0080090;nucleobase-containing compound catabolic process#GO:0034655;regulation of translation#GO:0006417;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;nuclear-transcribed mRNA catabolic process#GO:0000956;regulation of biosynthetic process#GO:0009889 organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=28420|UniProtKB=Q9BQD3 Q9BQD3 KXD1 PTHR13511:SF0 KXDL MOTIF-CONTAINING PROTEIN 1 KXDL MOTIF-CONTAINING PROTEIN 1 lysosome localization#GO:0032418;organelle localization#GO:0051640;localization#GO:0051179 protein-containing complex#GO:0032991;intracellular protein-containing complex#GO:0140535 HUMAN|HGNC=11867|UniProtKB=Q9UIK5 Q9UIK5 TMEFF2 PTHR10913:SF80 FOLLISTATIN-RELATED TOMOREGULIN-2 developmental process#GO:0032502;cellular process#GO:0009987;cell differentiation#GO:0030154;cellular developmental process#GO:0048869 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HUMAN|HGNC=257|UniProtKB=P55263 P55263 ADK PTHR45769:SF3 ADENOSINE KINASE ADENOSINE KINASE nucleoside kinase activity#GO:0019206;phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;nucleobase-containing compound kinase activity#GO:0019205;catalytic activity#GO:0003824 nucleobase metabolic process#GO:0009112;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;purine nucleobase metabolic process#GO:0006144;small molecule metabolic process#GO:0044281;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;cellular process#GO:0009987;purine-containing compound metabolic process#GO:0072521 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=29256|UniProtKB=A7XYQ1 A7XYQ1 SOBP PTHR23186:SF2 RETINOIC ACID-INDUCED PROTEIN 2 SINE OCULIS-BINDING PROTEIN HOMOLOG embryonic organ development#GO:0048568;animal gross anatomical part developmental process#GO:0160108;ear development#GO:0043583;anatomical structure development#GO:0048856;anatomical structure morphogenesis#GO:0009653;animal organ morphogenesis#GO:0009887;sensory organ morphogenesis#GO:0090596;developmental process#GO:0032502;sensory organ development#GO:0007423;embryonic morphogenesis#GO:0048598;multicellular organism development#GO:0007275;animal organ development#GO:0048513;inner ear morphogenesis#GO:0042472;inner ear development#GO:0048839;embryo development#GO:0009790;multicellular organismal process#GO:0032501 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=23408|UniProtKB=Q86YB7 Q86YB7 ECHDC2 PTHR11941:SF44 ENOYL-COA HYDRATASE-RELATED ENOYL-COA HYDRATASE DOMAIN-CONTAINING PROTEIN 2, MITOCHONDRIAL catalytic activity#GO:0003824;hydro-lyase activity#GO:0016836;lyase activity#GO:0016829;carbon-oxygen lyase activity#GO:0016835 monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;small molecule catabolic process#GO:0044282;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;oxoacid metabolic process#GO:0043436;fatty acid catabolic process#GO:0009062;lipid oxidation#GO:0034440;carboxylic acid catabolic process#GO:0046395;lipid catabolic process#GO:0016042;cellular process#GO:0009987;monocarboxylic acid catabolic process#GO:0072329;fatty acid oxidation#GO:0019395;fatty acid beta-oxidation#GO:0006635;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;lipid modification#GO:0030258 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 hydratase#PC00120;lyase#PC00144;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=10514|UniProtKB=P0DJI9 P0DJI9 SAA2 PTHR23424:SF32 SERUM AMYLOID A SERUM AMYLOID A-2 PROTEIN transfer/carrier protein#PC00219;apolipoprotein#PC00052 HUMAN|HGNC=8227|UniProtKB=Q8NH92 Q8NH92 OR1S1 PTHR48001:SF115 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 1S1-RELATED molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=711|UniProtKB=P49407 P49407 ARRB1 PTHR11792:SF22 ARRESTIN BETA-ARRESTIN-1 protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488;G protein-coupled receptor binding#GO:0001664 negative regulation of Notch signaling pathway#GO:0045746;positive regulation of intracellular signal transduction#GO:1902533;regulation of G protein-coupled receptor signaling pathway#GO:0008277;regulation of response to stimulus#GO:0048583;transport#GO:0006810;negative regulation of cellular process#GO:0048523;receptor-mediated endocytosis#GO:0006898;system process#GO:0003008;establishment of localization#GO:0051234;positive regulation of MAPK cascade#GO:0043410;positive regulation of cellular process#GO:0048522;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;multicellular organismal process#GO:0032501;negative regulation of response to stimulus#GO:0048585;sensory perception#GO:0007600;regulation of Notch signaling pathway#GO:0008593;localization#GO:0051179;positive regulation of signal transduction#GO:0009967;negative regulation of G protein-coupled receptor signaling pathway#GO:0045744;positive regulation of ERK1 and ERK2 cascade#GO:0070374;regulation of cell communication#GO:0010646;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of MAPK cascade#GO:0043408;import into cell#GO:0098657;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;receptor internalization#GO:0031623;negative regulation of signal transduction#GO:0009968;regulation of ERK1 and ERK2 cascade#GO:0070372;vesicle-mediated transport#GO:0016192;regulation of signaling#GO:0023051;nervous system process#GO:0050877;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;negative regulation of cell communication#GO:0010648;positive regulation of signaling#GO:0023056;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;endocytosis#GO:0006897 intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;cytosol#GO:0005829;intracellular vesicle#GO:0097708;cell periphery#GO:0071944;nucleus#GO:0005634;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>beta-arrestin#P00723;Wnt signaling pathway#P00057>beta-arrestin#P01456;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>beta-arrestin#P00880;Angiotensin II-stimulated signaling through G proteins and beta-arrestin#P05911>beta-ARR1#P05925 HUMAN|HGNC=29245|UniProtKB=Q8NET4 Q8NET4 RTL9 PTHR47702:SF1 RETROTRANSPOSON GAG-LIKE PROTEIN 9 RETROTRANSPOSON GAG-LIKE PROTEIN 9 viral or transposable element protein#PC00237 HUMAN|HGNC=7603|UniProtKB=Q9ULV0 Q9ULV0 MYO5B PTHR13140:SF356 MYOSIN UNCONVENTIONAL MYOSIN-VB microfilament motor activity#GO:0000146;polypeptide conformation or assembly isomerase activity#GO:0120544;catalytic activity#GO:0003824;ATP-dependent activity#GO:0140657;macromolecular conformation isomerase activity#GO:0120543;cytoskeletal motor activity#GO:0003774;isomerase activity#GO:0016853 cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029 actin cytoskeleton#GO:0015629;membrane#GO:0016020;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 actin binding motor protein#PC00040 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HUMAN|HGNC=11274|UniProtKB=P11277 P11277 SPTB PTHR11915:SF248 SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN SPECTRIN BETA CHAIN, ERYTHROCYTIC protein-containing complex binding#GO:0044877;protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;actin filament binding#GO:0051015;binding#GO:0005488 cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;actin filament-based process#GO:0030029;actin cytoskeleton organization#GO:0030036;cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010 cytoskeleton#GO:0005856;cell junction#GO:0030054;membraneless organelle#GO:0043228;membrane#GO:0016020;cell periphery#GO:0071944;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;cytoplasm#GO:0005737;cortical actin cytoskeleton#GO:0030864;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;actin cytoskeleton#GO:0015629;cortical cytoskeleton#GO:0030863;cell cortex#GO:0005938;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=33125|UniProtKB=Q6EKJ0 Q6EKJ0 GTF2IRD2B PTHR47831:SF1 GENERAL TRANSCRIPTION FACTOR II-I REPEAT DOMAIN-CONTAINING PROTEIN 2 GENERAL TRANSCRIPTION FACTOR II-I REPEAT DOMAIN-CONTAINING PROTEIN 2A-RELATED nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 general transcription factor#PC00259 HUMAN|HGNC=19179|UniProtKB=Q8IZV2 Q8IZV2 CMTM8 PTHR22776:SF10 MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN CKLF-LIKE MARVEL TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 8 signaling#GO:0023052;biological regulation#GO:0065007;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;membrane#GO:0016020 scaffold/adaptor protein#PC00226 HUMAN|HGNC=6453|UniProtKB=Q92764 Q92764 KRT35 PTHR23239:SF193 INTERMEDIATE FILAMENT KERATIN, TYPE I CUTICULAR HA5 structural molecule activity#GO:0005198 developmental process#GO:0032502;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;morphogenesis of an epithelium#GO:0002009;organelle organization#GO:0006996;cellular process#GO:0009987;epithelium development#GO:0060429;epithelial cell differentiation#GO:0030855;tissue development#GO:0009888;cytoskeleton organization#GO:0007010;intermediate filament-based process#GO:0045103;animal gross anatomical part developmental process#GO:0160108;intermediate filament organization#GO:0045109;tissue morphogenesis#GO:0048729;anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cell differentiation#GO:0030154;intermediate filament cytoskeleton organization#GO:0045104 intracellular anatomical structure#GO:0005622;intermediate filament#GO:0005882;supramolecular fiber#GO:0099512;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;organelle#GO:0043226;supramolecular complex#GO:0099080 intermediate filament#PC00129 HUMAN|HGNC=26047|UniProtKB=Q8WUE5 Q8WUE5 CT55 PTHR45418:SF1 CANCER/TESTIS ANTIGEN 55 CANCER_TESTIS ANTIGEN 55 HUMAN|HGNC=1818|UniProtKB=P40199 P40199 CEACAM6 PTHR44337:SF24 CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 8 CELL ADHESION MOLECULE CEACAM6 cell-cell adhesion#GO:0098609;homophilic cell-cell adhesion#GO:0007156;heterophilic cell-cell adhesion#GO:0007157;cellular process#GO:0009987;cell adhesion#GO:0007155 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 immunoglobulin superfamily cell adhesion molecule#PC00125;cell adhesion molecule#PC00069 HUMAN|HGNC=11199|UniProtKB=P41225 P41225 SOX3 PTHR10270:SF111 SOX TRANSCRIPTION FACTOR TRANSCRIPTION FACTOR SOX-3 sequence-specific double-stranded DNA binding#GO:1990837;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription cis-regulatory region binding#GO:0000976;sequence-specific DNA binding#GO:0043565;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulator activity#GO:0140110;DNA-binding transcription activator activity#GO:0001216 developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;brain development#GO:0007420;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;positive regulation of biosynthetic process#GO:0009891;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;neuron differentiation#GO:0030182;positive regulation of transcription by RNA polymerase II#GO:0045944;animal organ development#GO:0048513;multicellular organism development#GO:0007275;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;negative regulation of macromolecule biosynthetic process#GO:0010558;nervous system development#GO:0007399;head development#GO:0060322;positive regulation of macromolecule metabolic process#GO:0010604;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of DNA-templated transcription#GO:0045892;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;central nervous system development#GO:0007417 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264;HMG box transcription factor#PC00024 HUMAN|HGNC=19373|UniProtKB=Q53FA7 Q53FA7 TP53I3 PTHR48106:SF18 QUINONE OXIDOREDUCTASE PIG3-RELATED QUINONE OXIDOREDUCTASE PIG3 catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on NAD(P)H#GO:0016651;oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor#GO:0016655 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 Huntington disease#P00029>PIG3#G01535 HUMAN|HGNC=9988|UniProtKB=O00287 O00287 RFXAP PTHR15110:SF2 REGULATORY FACTOR X-ASSOCIATED PROTEIN REGULATORY FACTOR X-ASSOCIATED PROTEIN regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=16627|UniProtKB=O96017 O96017 CHEK2 PTHR44167:SF39 OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED SERINE_THREONINE-PROTEIN KINASE CHK2 transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 biological regulation#GO:0065007;DNA damage checkpoint signaling#GO:0000077;regulation of mitotic cell cycle#GO:0007346;mitotic DNA integrity checkpoint signaling#GO:0044774;DNA integrity checkpoint signaling#GO:0031570;mitotic cell cycle process#GO:1903047;negative regulation of cell cycle process#GO:0010948;DNA damage response#GO:0006974;negative regulation of cellular process#GO:0048523;regulation of cellular process#GO:0050794;mitotic cell cycle#GO:0000278;cellular response to stimulus#GO:0051716;mitotic DNA damage checkpoint signaling#GO:0044773;regulation of cell cycle phase transition#GO:1901987;cell cycle#GO:0007049;mitotic cell cycle checkpoint signaling#GO:0007093;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;regulation of cell cycle process#GO:0010564;cell cycle checkpoint signaling#GO:0000075;cellular process#GO:0009987;signal transduction#GO:0007165;response to stress#GO:0006950;negative regulation of cell cycle#GO:0045786;signaling#GO:0023052;regulation of cell cycle#GO:0051726;response to stimulus#GO:0050896;cell cycle process#GO:0022402;signal transduction in response to DNA damage#GO:0042770;regulation of biological process#GO:0050789;negative regulation of cell cycle phase transition#GO:1901988;negative regulation of biological process#GO:0048519;negative regulation of mitotic cell cycle#GO:0045930;cellular response to stress#GO:0033554 nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 p53 pathway#P00059>Chk2#P01484 HUMAN|HGNC=22962|UniProtKB=Q71F56 Q71F56 MED13L PTHR48249:SF1 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13-LIKE transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;transcription coactivator activity#GO:0003713 positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;positive regulation of RNA metabolic process#GO:0051254;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 mediator complex#GO:0016592;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634 HUMAN|HGNC=14276|UniProtKB=Q9BYD3 Q9BYD3 MRPL4 PTHR10746:SF18 50S RIBOSOMAL PROTEIN L4 LARGE RIBOSOMAL SUBUNIT PROTEIN UL4M structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 regulation of response to stimulus#GO:0048583;post-transcriptional regulation of gene expression#GO:0010608;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of response to stimulus#GO:0048584;regulation of Notch signaling pathway#GO:0008593;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;positive regulation of Notch signaling pathway#GO:0045747;regulation of macromolecule metabolic process#GO:0060255 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;ribosome#GO:0005840;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;organellar ribosome#GO:0000313;intracellular anatomical structure#GO:0005622;mitochondrial ribosome#GO:0005761;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;large ribosomal subunit#GO:0015934;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;membrane-enclosed lumen#GO:0031974;mitochondrial large ribosomal subunit#GO:0005762;membraneless organelle#GO:0043228 ribosomal protein#PC00202 HUMAN|HGNC=161|UniProtKB=Q9Y615 Q9Y615 ACTL7A PTHR11937:SF167 ACTIN ACTIN-LIKE PROTEIN 7A structural constituent of cytoskeleton#GO:0005200;structural molecule activity#GO:0005198 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;actin cytoskeleton#GO:0015629;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 actin and actin related protein#PC00039 HUMAN|HGNC=20368|UniProtKB=Q5T200 Q5T200 ZC3H13 PTHR13585:SF31 CHASCON, ISOFORM D-RELATED ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 13 RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;nuclear body#GO:0016604;transferase complex#GO:1990234;membraneless organelle#GO:0043228;organelle lumen#GO:0043233;nuclear speck#GO:0016607;organelle#GO:0043226;methyltransferase complex#GO:0034708;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=3374|UniProtKB=Q99814 Q99814 EPAS1 PTHR23043:SF8 HYPOXIA-INDUCIBLE FACTOR 1 ALPHA ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 chemical homeostasis#GO:0048878;anatomical structure formation involved in morphogenesis#GO:0048646;vasculature development#GO:0001944;multicellular organism development#GO:0007275;animal organ development#GO:0048513;cellular process#GO:0009987;response to stress#GO:0006950;response to chemical#GO:0042221;cellular response to stress#GO:0033554;immune system process#GO:0002376;cellular response to chemical stimulus#GO:0070887;animal gross anatomical part developmental process#GO:0160108;angiogenesis#GO:0001525;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;blood vessel morphogenesis#GO:0048514;response to abiotic stimulus#GO:0009628;cell development#GO:0048468;tissue remodeling#GO:0048771;cell differentiation#GO:0030154;circulatory system development#GO:0072359;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;myeloid cell differentiation#GO:0030099;developmental process#GO:0032502;intracellular chemical homeostasis#GO:0055082;response to hypoxia#GO:0001666;cellular homeostasis#GO:0019725;multicellular organismal-level homeostasis#GO:0048871;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;hemopoiesis#GO:0030097;tube development#GO:0035295;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;homeostasis of number of cells#GO:0048872;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;erythrocyte differentiation#GO:0030218;tube morphogenesis#GO:0035239;blood vessel development#GO:0001568;cellular response to stimulus#GO:0051716;response to decreased oxygen levels#GO:0036293;response to oxygen levels#GO:0070482;cellular response to hypoxia#GO:0071456;homeostatic process#GO:0042592;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 basic helix-loop-helix transcription factor#PC00055;DNA-binding transcription factor#PC00218 HUMAN|HGNC=3802|UniProtKB=Q16676 Q16676 FOXD1 PTHR11829:SF348 FORKHEAD BOX PROTEIN FORKHEAD BOX PROTEIN D1-RELATED RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 helix-turn-helix transcription factor#PC00116;gene-specific transcriptional regulator#PC00264;winged helix/forkhead transcription factor#PC00246 HUMAN|HGNC=28495|UniProtKB=Q8IZ20 Q8IZ20 ZNF683 PTHR24390:SF124 ZINC FINGER PROTEIN TISSUE-RESIDENT T-CELL TRANSCRIPTION REGULATOR PROTEIN ZNF683 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=1033|UniProtKB=P23560 P23560 BDNF PTHR11589:SF3 NERVE GROWTH FACTOR NGF -RELATED NEUROTROPHIC FACTOR BDNF PRECURSOR FORM signaling receptor regulator activity#GO:0030545;growth factor activity#GO:0008083;receptor ligand activity#GO:0048018;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677 animal gross anatomical part developmental process#GO:0160108;regulation of signaling#GO:0023051;generation of neurons#GO:0048699;neuron development#GO:0048666;cellular response to growth factor stimulus#GO:0071363;cellular component organization#GO:0016043;regulation of programmed cell death#GO:0043067;response to endogenous stimulus#GO:0009719;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;cell morphogenesis#GO:0000902;cellular response to endogenous stimulus#GO:0071495;cell projection organization#GO:0030030;cell differentiation#GO:0030154;response to stimulus#GO:0050896;cell development#GO:0048468;signaling#GO:0023052;regulation of apoptotic process#GO:0042981;cell surface receptor signaling pathway#GO:0007166;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;cellular response to nerve growth factor stimulus#GO:1990090;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cell projection morphogenesis#GO:0048858;negative regulation of neuron apoptotic process#GO:0043524;neuron projection development#GO:0031175;regulation of neuron apoptotic process#GO:0043523;cellular process#GO:0009987;negative regulation of programmed cell death#GO:0043069;signal transduction#GO:0007165;regulation of trans-synaptic signaling#GO:0099177;nervous system development#GO:0007399;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;system development#GO:0048731;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;response to growth factor#GO:0070848;regulation of cell communication#GO:0010646;modulation of chemical synaptic transmission#GO:0050804;negative regulation of cellular process#GO:0048523;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;multicellular organismal process#GO:0032501;negative regulation of apoptotic process#GO:0043066;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007 synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;synaptic vesicle#GO:0008021;vesicle#GO:0031982;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;exocytic vesicle#GO:0070382;extracellular region#GO:0005576;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;transport vesicle#GO:0030133;cytoplasm#GO:0005737;secretory vesicle#GO:0099503;presynapse#GO:0098793;cell junction#GO:0030054 neurotrophic factor#PC00163;growth factor#PC00112 Metabotropic glutamate receptor group II pathway#P00040>BDNF#G01540;Huntington disease#P00029>BDNF#G01531;Huntington disease#P00029>BDNF#P00795 HUMAN|HGNC=1306|UniProtKB=O15442 O15442 MPPED1 PTHR12905:SF31 METALLOPHOSPHOESTERASE METALLOPHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN 1 catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;hydrolase activity#GO:0016787;phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578;cyclic-nucleotide phosphodiesterase activity#GO:0004112 hydrolase#PC00121;esterase#PC00097;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=21090|UniProtKB=Q5T215 Q5T215 TRAPPC3L PTHR13048:SF1 TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 3 TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 3-LIKE PROTEIN guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589 vesicle-mediated transport#GO:0016192;intra-Golgi vesicle-mediated transport#GO:0006891;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;intracellular transport#GO:0046907;transport#GO:0006810;Golgi vesicle transport#GO:0048193 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;cytosol#GO:0005829;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;TRAPP complex#GO:0030008;Golgi apparatus#GO:0005794;intracellular protein-containing complex#GO:0140535;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;cis-Golgi network#GO:0005801;vesicle tethering complex#GO:0099023 HUMAN|HGNC=23615|UniProtKB=Q8IXU6 Q8IXU6 SLC35F2 PTHR14233:SF12 DUF914-RELATED QUEUINE_QUEUOSINE TRANSPORTER SLC35F2 HUMAN|HGNC=4517|UniProtKB=Q8IYL9 Q8IYL9 GPR65 PTHR24232:SF49 G-PROTEIN COUPLED RECEPTOR G PROTEIN-COUPLED RECEPTOR 65 transmembrane signaling receptor activity#GO:0004888;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=21497|UniProtKB=Q9H845 Q9H845 ACAD9 PTHR43884:SF9 ACYL-COA DEHYDROGENASE COMPLEX I ASSEMBLY FACTOR ACAD9, MITOCHONDRIAL catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;oxidoreductase activity#GO:0016491 oxidoreductase#PC00176;dehydrogenase#PC00092 HUMAN|HGNC=23238|UniProtKB=Q9BPX1 Q9BPX1 HSD17B14 PTHR43658:SF16 SHORT-CHAIN DEHYDROGENASE/REDUCTASE L-FUCOSE DEHYDROGENASE cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=319|UniProtKB=P16112 P16112 ACAN PTHR22804:SF42 AGGRECAN/VERSICAN PROTEOGLYCAN AGGRECAN CORE PROTEIN nervous system development#GO:0007399;central nervous system development#GO:0007417;multicellular organismal process#GO:0032501;system development#GO:0048731;skeletal system development#GO:0001501;multicellular organism development#GO:0007275;anatomical structure development#GO:0048856;developmental process#GO:0032502;animal gross anatomical part developmental process#GO:0160108 extracellular region#GO:0005576;cell junction#GO:0030054;cell periphery#GO:0071944;external encapsulating structure#GO:0030312;membrane#GO:0016020;extracellular matrix#GO:0031012;plasma membrane#GO:0005886;synapse#GO:0045202;cellular anatomical structure#GO:0110165 extracellular matrix protein#PC00102;extracellular matrix glycoprotein#PC00100 HUMAN|HGNC=6263|UniProtKB=P63252 P63252 KCNJ2 PTHR11767:SF43 INWARD RECTIFIER POTASSIUM CHANNEL INWARD RECTIFIER POTASSIUM CHANNEL 2 voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;ligand-gated monoatomic cation channel activity#GO:0099094;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;ligand-gated monoatomic ion channel activity#GO:0015276;potassium channel activity#GO:0005267 transport#GO:0006810;inorganic cation import across plasma membrane#GO:0098659;import into cell#GO:0098657;establishment of localization#GO:0051234;potassium ion import across plasma membrane#GO:1990573;cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;potassium ion transmembrane transport#GO:0071805;monoatomic cation transmembrane transport#GO:0098655;potassium ion transport#GO:0006813;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;inorganic ion import across plasma membrane#GO:0099587;metal ion transport#GO:0030001;import across plasma membrane#GO:0098739 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 ion channel#PC00133 HUMAN|HGNC=833|UniProtKB=P36542 P36542 ATP5F1C PTHR11693:SF31 ATP SYNTHASE GAMMA CHAIN ATP SYNTHASE F(1) COMPLEX SUBUNIT GAMMA, MITOCHONDRIAL monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;monoatomic cation channel activity#GO:0005261;proton channel activity#GO:0015252;passive transmembrane transporter activity#GO:0022803;catalytic activity#GO:0003824;proton transmembrane transporter activity#GO:0015078;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;ligase activity#GO:0016874;channel activity#GO:0015267;proton-transporting ATP synthase activity, rotational mechanism#GO:0046933;monoatomic cation transmembrane transporter activity#GO:0008324 nucleoside phosphate metabolic process#GO:0006753;nucleoside triphosphate metabolic process#GO:0009141;proton motive force-driven ATP synthesis#GO:0015986;purine nucleoside triphosphate biosynthetic process#GO:0009145;purine nucleoside triphosphate metabolic process#GO:0009144;primary metabolic process#GO:0044238;organophosphate biosynthetic process#GO:0090407;purine ribonucleoside triphosphate biosynthetic process#GO:0009206;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;purine ribonucleoside triphosphate metabolic process#GO:0009205;carbohydrate derivative metabolic process#GO:1901135;nucleoside triphosphate biosynthetic process#GO:0009142;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;nucleoside phosphate biosynthetic process#GO:1901293;small molecule metabolic process#GO:0044281;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;ribonucleotide metabolic process#GO:0009259;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;ribose phosphate metabolic process#GO:0019693;ATP metabolic process#GO:0046034;cellular process#GO:0009987;ribose phosphate biosynthetic process#GO:0046390;nucleobase-containing small molecule metabolic process#GO:0055086;ribonucleoside triphosphate biosynthetic process#GO:0009201;carbohydrate derivative biosynthetic process#GO:1901137;ATP biosynthetic process#GO:0006754;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 mitochondrial inner membrane#GO:0005743;organelle envelope#GO:0031967;membrane#GO:0016020;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622 ATP synthase#PC00002 ATP synthesis#P02721>F1 gamma#P02796 HUMAN|HGNC=26804|UniProtKB=Q8N8Q1 Q8N8Q1 CYB561D1 PTHR15422:SF9 OS05G0565100 PROTEIN TRANSMEMBRANE REDUCTASE CYB561D1-RELATED HUMAN|HGNC=25206|UniProtKB=Q8WV99 Q8WV99 ZFAND2B PTHR14677:SF13 ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED AN1-TYPE ZINC FINGER PROTEIN 2B catabolic process#GO:0009056;protein targeting#GO:0006605;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;localization#GO:0051179;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;establishment of protein localization to endoplasmic reticulum#GO:0072599;proteasomal protein catabolic process#GO:0010498;establishment of protein localization#GO:0045184;cellular process#GO:0009987;establishment of protein localization to organelle#GO:0072594;macromolecule metabolic process#GO:0043170;establishment of localization#GO:0051234;protein targeting to ER#GO:0045047;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 RNA metabolism protein#PC00031 HUMAN|HGNC=16949|UniProtKB=Q9NX05 Q9NX05 FAM120C PTHR15976:SF15 CONSTITUTIVE COACTIVATOR OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA CONSTITUTIVE COACTIVATOR OF PPAR-GAMMA-LIKE PROTEIN 2 HUMAN|HGNC=17303|UniProtKB=Q5VWG9 Q5VWG9 TAF3 PTHR46452:SF1 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 3 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 3 binding#GO:0005488;protein binding#GO:0005515 positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;positive regulation of RNA metabolic process#GO:0051254;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of DNA-templated transcription#GO:0006355 transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;RNA polymerase II, holoenzyme#GO:0016591;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;transcription regulator complex#GO:0005667;membrane-enclosed lumen#GO:0031974;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991;transcription factor TFIID complex#GO:0005669 HUMAN|HGNC=11357|UniProtKB=Q92783 Q92783 STAM PTHR45929:SF2 JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE SIGNAL TRANSDUCING ADAPTER MOLECULE 1 protein transport#GO:0015031;cellular localization#GO:0051641;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;late endosome to vacuole transport#GO:0045324;protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043328;establishment of protein localization to vacuole#GO:0072666;endosomal transport#GO:0016197;intracellular protein transport#GO:0006886;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;vesicle-mediated transport#GO:0016192;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;localization#GO:0051179;protein metabolic process#GO:0019538;protein localization to vacuole#GO:0072665;catabolic process#GO:0009056;protein localization to organelle#GO:0033365;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238;intracellular protein localization#GO:0008104;ubiquitin-dependent protein catabolic process#GO:0006511;establishment of protein localization to organelle#GO:0072594;macromolecule metabolic process#GO:0043170;establishment of localization#GO:0051234;vacuolar transport#GO:0007034;transport#GO:0006810;intracellular transport#GO:0046907;endosome transport via multivesicular body sorting pathway#GO:0032509;ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway#GO:0043162;multivesicular body sorting pathway#GO:0071985;late endosome to vacuole transport via multivesicular body sorting pathway#GO:0032511;macromolecule localization#GO:0033036 intracellular vesicle#GO:0097708;vesicle#GO:0031982;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endosome#GO:0005768;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227 scaffold/adaptor protein#PC00226 HUMAN|HGNC=30907|UniProtKB=O60504 O60504 SORBS3 PTHR14167:SF54 SH3 DOMAIN-CONTAINING VINEXIN protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 cellular process#GO:0009987;cell adhesion#GO:0007155;cellular component organization#GO:0016043;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;cell-substrate adhesion#GO:0031589;cellular component organization or biogenesis#GO:0071840 plasma membrane#GO:0005886;cell-substrate junction#GO:0030055;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;nucleus#GO:0005634;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;cell junction#GO:0030054;intracellular organelle#GO:0043229 scaffold/adaptor protein#PC00226 HUMAN|HGNC=13908|UniProtKB=Q96SC8 Q96SC8 DMRTA2 PTHR12322:SF76 DOUBLESEX AND MAB-3 RELATED TRANSCRIPTION FACTOR DMRT DOUBLESEX- AND MAB-3-RELATED TRANSCRIPTION FACTOR A2 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;sex differentiation#GO:0007548;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;developmental process involved in reproduction#GO:0003006;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;reproductive process#GO:0022414 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 DNA-binding transcription factor#PC00218 HUMAN|HGNC=11609|UniProtKB=P24557 P24557 TBXAS1 PTHR24301:SF17 THROMBOXANE-A SYNTHASE THROMBOXANE-A SYNTHASE isomerase activity#GO:0016853;intramolecular oxidoreductase activity#GO:0016860;catalytic activity#GO:0003824 isomerase#PC00135;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=28968|UniProtKB=Q14153 Q14153 FAM53B PTHR28567:SF1 PROTEIN FAM53A-LIKE ISOFORM X1 PROTEIN FAM53B regulation of biological process#GO:0050789;regulation of Wnt signaling pathway#GO:0030111;regulation of signaling#GO:0023051;positive regulation of signaling#GO:0023056;cellular localization#GO:0051641;protein import into nucleus#GO:0006606;protein transport#GO:0015031;regulation of canonical Wnt signaling pathway#GO:0060828;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;positive regulation of biological process#GO:0048518;positive regulation of Wnt signaling pathway#GO:0030177;intracellular protein transport#GO:0006886;positive regulation of signal transduction#GO:0009967;regulation of cellular process#GO:0050794;protein localization to organelle#GO:0033365;positive regulation of cell communication#GO:0010647;regulation of cell communication#GO:0010646;nucleocytoplasmic transport#GO:0006913;localization#GO:0051179;nuclear transport#GO:0051169;protein localization to nucleus#GO:0034504;macromolecule localization#GO:0033036;import into nucleus#GO:0051170;positive regulation of cellular process#GO:0048522;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;intracellular transport#GO:0046907;transport#GO:0006810;regulation of response to stimulus#GO:0048583;establishment of localization#GO:0051234;positive regulation of canonical Wnt signaling pathway#GO:0090263;establishment of protein localization to organelle#GO:0072594;intracellular protein localization#GO:0008104 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=21958|UniProtKB=A4D1E1 A4D1E1 ZNF804B PTHR17614:SF12 ZINC FINGER-CONTAINING ZINC FINGER PROTEIN 804B cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=30184|UniProtKB=A2A3K4 A2A3K4 PTPDC1 PTHR23339:SF123 TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE PROTEIN TYROSINE PHOSPHATASE DOMAIN-CONTAINING PROTEIN 1 hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787 organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031;cilium organization#GO:0044782;cellular component organization or biogenesis#GO:0071840;cell projection assembly#GO:0030031;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;cilium assembly#GO:0060271;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cell projection organization#GO:0030030 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HUMAN|HGNC=1711|UniProtKB=P48960 P48960 ADGRE5 PTHR12011:SF348 ADHESION G-PROTEIN COUPLED RECEPTOR ADHESION G PROTEIN-COUPLED RECEPTOR E5 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=1293|UniProtKB=P58511 P58511 SMIM11 PTHR35975:SF1 SMALL INTEGRAL MEMBRANE PROTEIN 11A SMALL INTEGRAL MEMBRANE PROTEIN 11 HUMAN|HGNC=6767|UniProtKB=Q15797 Q15797 SMAD1 PTHR13703:SF23 SMAD SMAD FAMILY MEMBER 1 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;protein binding#GO:0005515;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 cellular response to transforming growth factor beta stimulus#GO:0071560;BMP signaling pathway#GO:0030509;cellular response to stimulus#GO:0051716;regulation of macromolecule metabolic process#GO:0060255;response to growth factor#GO:0070848;regulation of cellular process#GO:0050794;response to transforming growth factor beta#GO:0071559;regulation of RNA metabolic process#GO:0051252;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;developmental process#GO:0032502;response to BMP#GO:0071772;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;signaling#GO:0023052;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;cell differentiation#GO:0030154;cellular response to endogenous stimulus#GO:0071495;cellular response to growth factor stimulus#GO:0071363;signal transduction#GO:0007165;cellular process#GO:0009987;transforming growth factor beta receptor signaling pathway#GO:0007179;intracellular signaling cassette#GO:0141124;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;cellular response to BMP stimulus#GO:0071773;cell surface receptor signaling pathway#GO:0007166 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218 Gonadotropin-releasing hormone receptor pathway#P06664>SMAD1/5/8#P06787;Gonadotropin-releasing hormone receptor pathway#P06664>SMAD2-4#P06819;TGF-beta signaling pathway#P00052>RSmads#P01292;Wnt signaling pathway#P00057>Smad4#P01455 HUMAN|HGNC=9521|UniProtKB=Q00888 Q00888 PSG4 PTHR44427:SF13 CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 19 PREGNANCY-SPECIFIC BETA-1-GLYCOPROTEIN 4-RELATED cell adhesion molecule#PC00069 HUMAN|HGNC=16216|UniProtKB=Q9H1P6 Q9H1P6 CIMIP1 PTHR31909:SF3 CHROMOSOME 20 ORF85 FAMILY MEMBER CILIARY MICROTUBULE INNER PROTEIN 1 HUMAN|HGNC=10563|UniProtKB=O15126 O15126 SCAMP1 PTHR10687:SF8 SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN SCAMP SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN 1 export from cell#GO:0140352;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;secretion by cell#GO:0032940;exocytosis#GO:0006887;localization#GO:0051179;secretion#GO:0046903;establishment of localization#GO:0051234;transport#GO:0006810 intracellular organelle#GO:0043229;endosome#GO:0005768;endosome membrane#GO:0010008;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;recycling endosome#GO:0055037;recycling endosome membrane#GO:0055038;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;vesicle membrane#GO:0012506;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;cytoplasmic vesicle membrane#GO:0030659;trans-Golgi network membrane#GO:0032588;endomembrane system#GO:0012505;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737 transfer/carrier protein#PC00219 HUMAN|HGNC=11319|UniProtKB=P28290 P28290 ITPRID2 PTHR17469:SF11 SPERM SPECIFIC ANTIGEN 2-RELATED PROTEIN ITPRID2 cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;actin filament binding#GO:0051015;binding#GO:0005488;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 HUMAN|HGNC=25267|UniProtKB=Q96LY2 Q96LY2 CCDC74B PTHR14882:SF7 COILED-COIL DOMAIN-CONTAINING 74A COILED-COIL DOMAIN-CONTAINING PROTEIN 74A-RELATED HUMAN|HGNC=7971|UniProtKB=P13056 P13056 NR2C1 PTHR24083:SF49 NUCLEAR HORMONE RECEPTOR NUCLEAR RECEPTOR SUBFAMILY 2 GROUP C MEMBER 1 sequence-specific double-stranded DNA binding#GO:1990837;molecular transducer activity#GO:0060089;cis-regulatory region sequence-specific DNA binding#GO:0000987;nuclear receptor activity#GO:0004879;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulator activity#GO:0140110 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;developmental process#GO:0032502;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 C4 zinc finger nuclear receptor#PC00169;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=268|UniProtKB=P0DMS8 P0DMS8 ADORA3 PTHR24246:SF2 OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR ADENOSINE RECEPTOR A3 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;G protein-coupled adenosine receptor signaling pathway#GO:0001973;cell surface receptor signaling pathway#GO:0007166;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154 cell junction#GO:0030054;dendritic tree#GO:0097447;dendrite#GO:0030425;somatodendritic compartment#GO:0036477;cell projection#GO:0042995;plasma membrane#GO:0005886;plasma membrane bounded cell projection#GO:0120025;synapse#GO:0045202;cellular anatomical structure#GO:0110165;neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GoPCR#P00725 HUMAN|HGNC=24257|UniProtKB=Q9HC24 Q9HC24 TMBIM4 PTHR23291:SF50 BAX INHIBITOR-RELATED PROTEIN LIFEGUARD 4 channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;calcium ion transmembrane transporter activity#GO:0015085;calcium channel activity#GO:0005262;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;metal ion transmembrane transporter activity#GO:0046873;monoatomic cation channel activity#GO:0005261;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075 response to stress#GO:0006950;endoplasmic reticulum unfolded protein response#GO:0030968;cellular process#GO:0009987;signal transduction#GO:0007165;biological regulation#GO:0065007;cellular response to unfolded protein#GO:0034620;response to endoplasmic reticulum stress#GO:0034976;cellular response to topologically incorrect protein#GO:0035967;cellular response to stress#GO:0033554;cell communication#GO:0007154;response to unfolded protein#GO:0006986;intracellular signal transduction#GO:0035556;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;response to topologically incorrect protein#GO:0035966;signaling#GO:0023052 membrane#GO:0016020;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984 ion channel#PC00133;transporter#PC00227 HUMAN|HGNC=30544|UniProtKB=Q96HV5 Q96HV5 TMEM41A PTHR43220:SF21 FAMILY NOT NAMED TRANSMEMBRANE PROTEIN 41A HUMAN|HGNC=16505|UniProtKB=Q8WWM9 Q8WWM9 CYGB PTHR46783:SF2 CYTOGLOBIN CYTOGLOBIN heme binding#GO:0020037;catalytic activity#GO:0003824;binding#GO:0005488;tetrapyrrole binding#GO:0046906;oxidoreductase activity#GO:0016491 HUMAN|HGNC=19745|UniProtKB=Q9NQZ7 Q9NQZ7 ENTPD7 PTHR11782:SF37 ADENOSINE/GUANOSINE DIPHOSPHATASE ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 7 ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleoside diphosphate phosphatase activity#GO:0017110;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;pyrophosphatase activity#GO:0016462 nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;nucleotide catabolic process#GO:0009166;nucleobase-containing compound metabolic process#GO:0006139;carbohydrate derivative metabolic process#GO:1901135;ribonucleotide catabolic process#GO:0009261;ribose phosphate metabolic process#GO:0019693;pyrimidine-containing compound metabolic process#GO:0072527;cellular process#GO:0009987;nucleobase-containing compound catabolic process#GO:0034655;organophosphate metabolic process#GO:0019637;organophosphate catabolic process#GO:0046434;ribonucleoside diphosphate catabolic process#GO:0009191;nucleotide metabolic process#GO:0009117;nucleoside diphosphate metabolic process#GO:0009132;ribonucleotide metabolic process#GO:0009259;nucleoside phosphate metabolic process#GO:0006753;carbohydrate derivative catabolic process#GO:1901136;nucleoside triphosphate metabolic process#GO:0009141;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;nucleoside phosphate catabolic process#GO:1901292;nucleoside diphosphate catabolic process#GO:0009134;ribonucleoside diphosphate metabolic process#GO:0009185;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238 membrane#GO:0016020;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 phosphatase#PC00181;hydrolase#PC00121;nucleotide phosphatase#PC00173 HUMAN|HGNC=16775|UniProtKB=Q9BYU5 Q9BYU5 KRTAP2-1 PTHR48425:SF1 KERATIN-ASSOCIATED PROTEIN 2-1 KERATIN-ASSOCIATED PROTEIN 2-1 HUMAN|HGNC=13280|UniProtKB=Q96HE7 Q96HE7 ERO1A PTHR12613:SF1 ERO1-RELATED ERO1-LIKE PROTEIN ALPHA catalytic activity#GO:0003824;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;disulfide oxidoreductase activity#GO:0015036;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491;protein-disulfide reductase activity#GO:0015035 cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;signal transduction#GO:0007165;response to stress#GO:0006950;endoplasmic reticulum unfolded protein response#GO:0030968;biological regulation#GO:0065007;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;primary metabolic process#GO:0044238;protein folding#GO:0006457;signaling#GO:0023052;response to topologically incorrect protein#GO:0035966;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to topologically incorrect protein#GO:0035967;cellular response to stress#GO:0033554;cellular response to unfolded protein#GO:0034620;response to endoplasmic reticulum stress#GO:0034976;intracellular signal transduction#GO:0035556;protein metabolic process#GO:0019538;cell communication#GO:0007154;response to unfolded protein#GO:0006986 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum membrane#GO:0005789;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=11554|UniProtKB=P37802 P37802 TAGLN2 PTHR47385:SF20 CALPONIN TRANSGELIN-2 actin filament binding#GO:0051015;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cellular component organization or biogenesis#GO:0071840;actin filament-based process#GO:0030029;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;actin cytoskeleton#GO:0015629;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232 HUMAN|HGNC=3244|UniProtKB=Q9NZN3 Q9NZN3 EHD3 PTHR11216:SF67 EH DOMAIN EH DOMAIN-CONTAINING PROTEIN 3 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 establishment of localization in cell#GO:0051649;cell projection assembly#GO:0030031;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;macromolecule localization#GO:0033036;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;vesicle-mediated transport#GO:0016192;transport#GO:0006810;plasma membrane bounded cell projection assembly#GO:0120031;protein localization to cell periphery#GO:1990778;intracellular transport#GO:0046907;endosomal transport#GO:0016197;vesicle-mediated transport to the plasma membrane#GO:0098876;intracellular protein localization#GO:0008104;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;import into cell#GO:0098657;protein localization to membrane#GO:0072657;protein localization to plasma membrane#GO:0072659;cellular component organization#GO:0016043;cilium assembly#GO:0060271;endocytic recycling#GO:0032456;cell projection organization#GO:0030030;endocytosis#GO:0006897;localization within membrane#GO:0051668;organelle assembly#GO:0070925;cilium organization#GO:0044782;localization#GO:0051179;cellular localization#GO:0051641 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;early endosome#GO:0005769;endocytic vesicle#GO:0030139;endosome#GO:0005768;endosome membrane#GO:0010008;intracellular organelle#GO:0043229;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;cytoplasm#GO:0005737;perinuclear region of cytoplasm#GO:0048471;plasma membrane#GO:0005886;membrane#GO:0016020;vesicle membrane#GO:0012506;cell periphery#GO:0071944;recycling endosome membrane#GO:0055038;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;recycling endosome#GO:0055037 membrane traffic protein#PC00150 HUMAN|HGNC=17269|UniProtKB=Q96PC2 Q96PC2 IP6K3 PTHR12400:SF40 INOSITOL POLYPHOSPHATE KINASE INOSITOL HEXAKISPHOSPHATE KINASE 3 phosphotransferase activity, phosphate group as acceptor#GO:0016776;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301 phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;phospholipid metabolic process#GO:0006644;phospholipid biosynthetic process#GO:0008654;small molecule metabolic process#GO:0044281;glycerolipid metabolic process#GO:0046486;phosphatidylinositol phosphate biosynthetic process#GO:0046854;organophosphate biosynthetic process#GO:0090407;glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987;alcohol biosynthetic process#GO:0046165;organophosphate metabolic process#GO:0019637;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;glycerophospholipid metabolic process#GO:0006650;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;glycerophospholipid biosynthetic process#GO:0046474;alcohol metabolic process#GO:0006066;metabolic process#GO:0008152 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634 kinase#PC00137 HUMAN|HGNC=7417|UniProtKB=Q96DY7 Q96DY7 MTBP PTHR14382:SF1 MDM2-BINDING PROTEIN MDM2-BINDING PROTEIN positive regulation of cell cycle G1/S phase transition#GO:1902808;positive regulation of mitotic cell cycle#GO:0045931;intracellular protein localization#GO:0008104;regulation of mitotic cell cycle#GO:0007346;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;protein localization to kinetochore#GO:0034501;macromolecule localization#GO:0033036;positive regulation of cell cycle#GO:0045787;regulation of cell cycle process#GO:0010564;biological regulation#GO:0065007;regulation of G1/S transition of mitotic cell cycle#GO:2000045;localization#GO:0051179;regulation of mitotic cell cycle phase transition#GO:1901990;positive regulation of cell cycle process#GO:0090068;regulation of biological process#GO:0050789;regulation of cell cycle phase transition#GO:1901987;regulation of cell cycle#GO:0051726;regulation of cell cycle G1/S phase transition#GO:1902806;protein localization to organelle#GO:0033365;regulation of cellular process#GO:0050794 kinetochore#GO:0000776;chromosome#GO:0005694;condensed chromosome, centromeric region#GO:0000779;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;supramolecular complex#GO:0099080;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;chromosome, centromeric region#GO:0000775;condensed chromosome#GO:0000793;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 HUMAN|HGNC=27088|UniProtKB=A6NCI4 A6NCI4 VWA3A PTHR46478:SF1 VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 3A VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 3A HUMAN|HGNC=4535|UniProtKB=Q9NQS5 Q9NQS5 GPR84 PTHR24230:SF59 G-PROTEIN COUPLED RECEPTOR G PROTEIN-COUPLED RECEPTOR 84 G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;neuropeptide signaling pathway#GO:0007218;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021 HUMAN|HGNC=15683|UniProtKB=Q9C0J1 Q9C0J1 B3GNT4 PTHR11214:SF368 BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE N-ACETYLLACTOSAMINIDE BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE 4 acetylglucosaminyltransferase activity#GO:0008375;UDP-glycosyltransferase activity#GO:0008194;glycosyltransferase activity#GO:0016757;hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;catalytic activity#GO:0003824 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;aminoglycan biosynthetic process#GO:0006023;biosynthetic process#GO:0009058;metabolic process#GO:0008152;aminoglycan metabolic process#GO:0006022;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170 membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;bounding membrane of organelle#GO:0098588;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020 transferase#PC00220;glycosyltransferase#PC00111 HUMAN|HGNC=935|UniProtKB=O14867 O14867 BACH1 PTHR46105:SF1 AGAP004733-PA TRANSCRIPTION REGULATOR PROTEIN BACH1 cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=26303|UniProtKB=Q8TE99 Q8TE99 PXYLP1 PTHR11567:SF213 ACID PHOSPHATASE-RELATED 2-PHOSPHOXYLOSE PHOSPHATASE 1 phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578 protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;proteoglycan metabolic process#GO:0006029;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;chondroitin sulfate proteoglycan metabolic process#GO:0050654;protein O-linked glycosylation#GO:0006493;carbohydrate derivative metabolic process#GO:1901135;glycoprotein biosynthetic process#GO:0009101;chondroitin sulfate proteoglycan biosynthetic process#GO:0050650;proteoglycan biosynthetic process#GO:0030166;biosynthetic process#GO:0009058 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 phosphatase#PC00181 HUMAN|HGNC=44663|UniProtKB=I3L273 I3L273 GFY PTHR47641:SF14 PERIAXIN-LIKE GOLGI-ASSOCIATED OLFACTORY SIGNALING REGULATOR HUMAN|HGNC=7584|UniProtKB=P08590 P08590 MYL3 PTHR23048:SF2 MYOSIN LIGHT CHAIN 1, 3 MYOSIN LIGHT CHAIN 3 ATP-dependent activity#GO:0140657;polypeptide conformation or assembly isomerase activity#GO:0120544;isomerase activity#GO:0016853;structural molecule activity#GO:0005198;cytoskeletal motor activity#GO:0003774;macromolecular conformation isomerase activity#GO:0120543;catalytic activity#GO:0003824;microfilament motor activity#GO:0000146 intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;myosin complex#GO:0016459;actin cytoskeleton#GO:0015629;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=18398|UniProtKB=Q9H4L7 Q9H4L7 SMARCAD1 PTHR10799:SF964 SNF2/RAD54 HELICASE FAMILY SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A CONTAINING DEAD_H BOX 1 ATP-dependent activity, acting on DNA#GO:0008094;DNA binding#GO:0003677;ATP-dependent activity#GO:0140657;chromatin binding#GO:0003682;nucleic acid binding#GO:0003676;binding#GO:0005488;catalytic activity, acting on DNA#GO:0140097;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 cellular response to stress#GO:0033554;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;DNA metabolic process#GO:0006259;positive regulation of transcription by RNA polymerase II#GO:0045944;metabolic process#GO:0008152;double-strand break repair#GO:0006302;negative regulation of gene expression, epigenetic#GO:0045814;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;response to stress#GO:0006950;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;heterochromatin organization#GO:0070828;cellular component assembly#GO:0022607;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;cellular response to stimulus#GO:0051716;heterochromatin formation#GO:0031507;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;DNA damage response#GO:0006974;negative regulation of cellular process#GO:0048523;DNA repair#GO:0006281;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;DNA double-strand break processing#GO:0000729;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;chromatin organization#GO:0006325;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;negative regulation of biosynthetic process#GO:0009890;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219 chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228 DNA helicase#PC00011;DNA metabolism protein#PC00009 HUMAN|HGNC=18131|UniProtKB=Q71H61 Q71H61 ILDR2 PTHR15923:SF0 TRANSMEMBRANE AND IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN IMMUNOGLOBULIN-LIKE DOMAIN-CONTAINING RECEPTOR 2 animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502;pancreas development#GO:0031016;anatomical structure development#GO:0048856;animal organ development#GO:0048513 membrane#GO:0016020;cellular anatomical structure#GO:0110165 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=1596|UniProtKB=O75909 O75909 CCNK PTHR10026:SF144 CYCLIN CYCLIN-K cyclin-dependent protein kinase regulator activity#GO:0019914;protein kinase regulator activity#GO:0019887;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;enzyme activator activity#GO:0008047;protein serine/threonine kinase activator activity#GO:0043539;cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538;protein kinase activator activity#GO:0030295;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;kinase activator activity#GO:0019209 positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription elongation#GO:0032784;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;positive regulation of DNA-templated transcription, elongation#GO:0032786;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522 nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;protein-containing complex#GO:0032991;transferase complex#GO:1990234;protein kinase complex#GO:1902911;nuclear protein-containing complex#GO:0140513;organelle lumen#GO:0043233;transcription elongation factor complex#GO:0008023;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;serine/threonine protein kinase complex#GO:1902554;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 kinase activator#PC00138;kinase modulator#PC00140 Cell cycle#P00013>CdkC#P00489 HUMAN|HGNC=34059|UniProtKB=A6NLX4 A6NLX4 TMEM210 PTHR39234:SF1 TRANSMEMBRANE PROTEIN 210 TRANSMEMBRANE PROTEIN 210 intracellular vesicle#GO:0097708;secretory vesicle#GO:0099503;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;acrosomal vesicle#GO:0001669;intracellular organelle#GO:0043229;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=9298|UniProtKB=Q96SB3 Q96SB3 PPP1R9B PTHR16154:SF24 NEURABIN NEURABIN-2 binding#GO:0005488;protein-macromolecule adaptor activity#GO:0030674;actin filament binding#GO:0051015;actin binding#GO:0003779;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;protein-membrane adaptor activity#GO:0043495;molecular adaptor activity#GO:0060090;cytoskeletal protein binding#GO:0008092 neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;cell differentiation#GO:0030154;response to stimulus#GO:0050896;cell projection organization#GO:0030030;cell development#GO:0048468;signaling#GO:0023052;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;neuron differentiation#GO:0030182;intracellular signaling cassette#GO:0141124;nervous system development#GO:0007399;cytoskeleton organization#GO:0007010;neuron projection development#GO:0031175;organelle organization#GO:0006996;cellular process#GO:0009987;signal transduction#GO:0007165;anatomical structure development#GO:0048856;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;supramolecular fiber organization#GO:0097435;system development#GO:0048731;actin filament-based process#GO:0030029;regulation of cellular process#GO:0050794;actin cytoskeleton organization#GO:0030036;cellular response to stimulus#GO:0051716;cellular developmental process#GO:0048869;calcium-mediated signaling#GO:0019722;neurogenesis#GO:0022008;actin filament organization#GO:0007015;developmental process#GO:0032502;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007 cell periphery#GO:0071944;neuron projection#GO:0043005;neuron to neuron synapse#GO:0098984;postsynaptic specialization#GO:0099572;cytoplasm#GO:0005737;cortical actin cytoskeleton#GO:0030864;intracellular membraneless organelle#GO:0043232;somatodendritic compartment#GO:0036477;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;cell junction#GO:0030054;postsynapse#GO:0098794;cortical cytoskeleton#GO:0030863;actin cytoskeleton#GO:0015629;actin-based cell projection#GO:0098858;cell cortex#GO:0005938;cellular anatomical structure#GO:0110165;synapse#GO:0045202;asymmetric synapse#GO:0032279;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;dendrite#GO:0030425;filopodium#GO:0030175;postsynaptic density#GO:0014069;dendritic tree#GO:0097447;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=25542|UniProtKB=Q2NL82 Q2NL82 TSR1 PTHR12858:SF1 RIBOSOME BIOGENESIS PROTEIN PRE-RRNA-PROCESSING PROTEIN TSR1 HOMOLOG RNA binding#GO:0003723;hydrolase activity#GO:0016787;binding#GO:0005488;nucleic acid binding#GO:0003676;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462 macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;ribosomal small subunit biogenesis#GO:0042274;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;maturation of SSU-rRNA#GO:0030490;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000479;cellular component biogenesis#GO:0044085;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;ribonucleoprotein complex biogenesis#GO:0022613;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 organelle lumen#GO:0043233;90S preribosome#GO:0030686;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;ribonucleoprotein complex#GO:1990904;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;preribosome#GO:0030684;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membraneless organelle#GO:0043228 HUMAN|HGNC=30138|UniProtKB=Q8N131 Q8N131 TMEM123 PTHR11337:SF14 MUCIN/PORIMIN PORIMIN cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HUMAN|HGNC=1666|UniProtKB=P11049 P11049 CD37 PTHR19282:SF263 TETRASPANIN LEUKOCYTE ANTIGEN CD37 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HUMAN|HGNC=17097|UniProtKB=Q13868 Q13868 EXOSC2 PTHR21321:SF4 PNAS-3 RELATED EXOSOME COMPLEX COMPONENT RRP4 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 rRNA processing#GO:0006364;snRNA metabolic process#GO:0016073;RNA metabolic process#GO:0016070;RNA catabolic process#GO:0006401;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;ribonucleoprotein complex biogenesis#GO:0022613;snRNA 3'-end processing#GO:0034472;maturation of 5.8S rRNA#GO:0000460;RNA biosynthetic process#GO:0032774;catabolic process#GO:0009056;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;snRNA processing#GO:0016180;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;nucleic acid catabolic process#GO:0141188;nucleobase-containing compound catabolic process#GO:0034655;cellular component biogenesis#GO:0044085 catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 RNA processing factor#PC00147 HUMAN|HGNC=24427|UniProtKB=Q6P093 Q6P093 AADACL2 PTHR23024:SF223 ARYLACETAMIDE DEACETYLASE ARYLACETAMIDE DEACETYLASE-LIKE 2 membrane#GO:0016020;cellular anatomical structure#GO:0110165 deacetylase#PC00087 HUMAN|HGNC=32415|UniProtKB=P0DJD1 P0DJD1 RGPD2 PTHR23138:SF168 RAN BINDING PROTEIN RANBP2-LIKE AND GRIP DOMAIN-CONTAINING PROTEIN 1-RELATED transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746;SUMO transferase activity#GO:0019789;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755 nucleocytoplasmic transport#GO:0006913;cellular localization#GO:0051641;localization#GO:0051179;NLS-bearing protein import into nucleus#GO:0006607;nuclear export#GO:0051168;protein transport#GO:0015031;protein import into nucleus#GO:0006606;nuclear transport#GO:0051169;protein localization to organelle#GO:0033365;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;intracellular protein localization#GO:0008104;protein localization to nucleus#GO:0034504;macromolecule localization#GO:0033036;import into nucleus#GO:0051170;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649 intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear pore#GO:0005643;organelle envelope#GO:0031967;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231 scaffold/adaptor protein#PC00226 HUMAN|HGNC=16936|UniProtKB=Q86VZ4 Q86VZ4 LRP11 PTHR46876:SF1 LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 11 LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 11 HUMAN|HGNC=1960|UniProtKB=P36544 P36544 CHRNA7 PTHR18945:SF907 NEUROTRANSMITTER GATED ION CHANNEL NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-7 gated channel activity#GO:0022836;postsynaptic neurotransmitter receptor activity#GO:0098960;monoatomic cation transmembrane transporter activity#GO:0008324;neurotransmitter receptor activity#GO:0030594;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;signaling receptor activity#GO:0038023;ligand-gated monoatomic ion channel activity#GO:0015276;molecular transducer activity#GO:0060089;channel activity#GO:0015267;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;ligand-gated monoatomic cation channel activity#GO:0099094;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;monoatomic cation channel activity#GO:0005261 transmembrane transport#GO:0055085;localization#GO:0051179;cell communication#GO:0007154;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;trans-synaptic signaling#GO:0099537;anterograde trans-synaptic signaling#GO:0098916;signaling#GO:0023052;metal ion transport#GO:0030001;chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;establishment of localization#GO:0051234;regulation of membrane potential#GO:0042391;calcium ion transport#GO:0006816;transport#GO:0006810;synaptic transmission, cholinergic#GO:0007271;monoatomic ion transmembrane transport#GO:0034220;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;synaptic signaling#GO:0099536;cellular process#GO:0009987 membrane protein complex#GO:0098796;postsynapse#GO:0098794;cell body#GO:0044297;plasma membrane protein complex#GO:0098797;synapse#GO:0045202;cellular anatomical structure#GO:0110165;neuronal cell body#GO:0043025;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;postsynaptic membrane#GO:0045211;axon#GO:0030424;transmembrane transporter complex#GO:1902495;membrane#GO:0016020;presynapse#GO:0098793;neuron projection#GO:0043005;cell periphery#GO:0071944;plasma membrane region#GO:0098590;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;presynaptic membrane#GO:0042734;synaptic membrane#GO:0097060;signaling receptor complex#GO:0043235;cell junction#GO:0030054;transporter complex#GO:1990351 ligand-gated ion channel#PC00141 Nicotinic acetylcholine receptor signaling pathway#P00044>nAChR#P01086;Nicotinic acetylcholine receptor signaling pathway#P00044>alpha#P01088;Alzheimer disease-amyloid secretase pathway#P00003>alpha7 nicotinic acetylcholine receptor#P00079 HUMAN|HGNC=9112|UniProtKB=Q6P1K2 Q6P1K2 PMF1 PTHR15459:SF4 POLYAMINE-MODULATED FACTOR 1 POLYAMINE-MODULATED FACTOR 1 cell cycle#GO:0007049;chromosome segregation#GO:0007059;cell cycle process#GO:0022402;cellular process#GO:0009987 intracellular organelle#GO:0043229;chromosome, centromeric region#GO:0000775;condensed chromosome#GO:0000793;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;outer kinetochore#GO:0000940;membraneless organelle#GO:0043228;kinetochore#GO:0000776;chromosome#GO:0005694;condensed chromosome, centromeric region#GO:0000779;intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 HUMAN|HGNC=15818|UniProtKB=Q9H0Z9 Q9H0Z9 RBM38 PTHR48024:SF28 GEO13361P1-RELATED RNA-BINDING PROTEIN 38 mRNA 3'-UTR binding#GO:0003730;RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA splicing#GO:0043484 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cytosol#GO:0005829;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HUMAN|Ensembl=ENSG00000292320.1|UniProtKB=A0AAG2UYG2 A0AAG2UYG2 LOC112268390 PTHR16035:SF14 PROTEIN FAM90A1 PROTEIN FAM90A10-RELATED HUMAN|HGNC=862|UniProtKB=O95670 O95670 ATP6V1G2 PTHR12713:SF13 VACUOLAR ATP SYNTHASE SUBUNIT G V-TYPE PROTON ATPASE SUBUNIT G 2 organelle organization#GO:0006996;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;developmental maturation#GO:0021700;vesicle-mediated transport#GO:0016192;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;developmental process#GO:0032502;transport#GO:0006810;synaptic vesicle cycle#GO:0099504;synaptic vesicle maturation#GO:0016188;proton transmembrane transport#GO:1902600;cellular component organization or biogenesis#GO:0071840;vesicle-mediated transport in synapse#GO:0099003;establishment of localization#GO:0051234;vesicle organization#GO:0016050;cellular homeostasis#GO:0019725;cellular component organization#GO:0016043;homeostatic process#GO:0042592;monoatomic cation transport#GO:0006812;localization#GO:0051179;cellular localization#GO:0051641;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811 transporter complex#GO:1990351;cell junction#GO:0030054;bounding membrane of organelle#GO:0098588;proton-transporting two-sector ATPase complex#GO:0016469;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;vacuole#GO:0005773;secretory vesicle#GO:0099503;presynapse#GO:0098793;ATPase dependent transmembrane transport complex#GO:0098533;exocytic vesicle#GO:0070382;ATPase complex#GO:1904949;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;synapse#GO:0045202;organelle#GO:0043226;intracellular vesicle#GO:0097708;vacuolar membrane#GO:0005774;organelle membrane#GO:0031090;proton-transporting V-type ATPase complex#GO:0033176;endomembrane system#GO:0012505;transport vesicle membrane#GO:0030658;transport vesicle#GO:0030133;membrane#GO:0016020;vesicle membrane#GO:0012506;transmembrane transporter complex#GO:1902495;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;catalytic complex#GO:1902494;vacuolar proton-transporting V-type ATPase complex#GO:0016471;vacuolar proton-transporting V-type ATPase, V1 domain#GO:0000221;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;cation-transporting ATPase complex#GO:0090533;synaptic vesicle#GO:0008021;vesicle#GO:0031982;synaptic vesicle membrane#GO:0030672 ATP synthase#PC00002 B cell activation#P00010>I kappa B#P00392 HUMAN|HGNC=3705|UniProtKB=O43427 O43427 FIBP PTHR13223:SF2 ACIDIC FIBROBLAST GROWTH FACTOR INTRACELLULAR BINDING PROTEIN ACIDIC FIBROBLAST GROWTH FACTOR INTRACELLULAR-BINDING PROTEIN fibroblast growth factor binding#GO:0017134;protein binding#GO:0005515;growth factor binding#GO:0019838;binding#GO:0005488 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=10477|UniProtKB=P19793 P19793 RXRA PTHR24083:SF39 NUCLEAR HORMONE RECEPTOR RETINOIC ACID RECEPTOR RXR-ALPHA sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;molecular transducer activity#GO:0060089;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;nuclear receptor activity#GO:0004879;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976 system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;intracellular signal transduction#GO:0035556;positive regulation of biosynthetic process#GO:0009891;cell communication#GO:0007154;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;cellular response to stimulus#GO:0051716;intracellular receptor signaling pathway#GO:0030522;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;developmental process#GO:0032502;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;nuclear receptor-mediated signaling pathway#GO:0141193;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;positive regulation of DNA-templated transcription#GO:0045893;cellular response to chemical stimulus#GO:0070887;animal gross anatomical part developmental process#GO:0160108;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;hormone-mediated signaling pathway#GO:0009755;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;signaling#GO:0023052;cell differentiation#GO:0030154;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;regulation of transcription by RNA polymerase II#GO:0006357;cellular response to hormone stimulus#GO:0032870;positive regulation of transcription by RNA polymerase II#GO:0045944;multicellular organism development#GO:0007275;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;response to hormone#GO:0009725;nervous system development#GO:0007399;response to chemical#GO:0042221;positive regulation of macromolecule metabolic process#GO:0010604 nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 C4 zinc finger nuclear receptor#PC00169;gene-specific transcriptional regulator#PC00264 Vitamin D metabolism and pathway#P04396>RXR#P04602 HUMAN|HGNC=33792|UniProtKB=A2A2V5 A2A2V5 SERTM1 PTHR35660:SF1 SERINE-RICH AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 1 SERINE-RICH AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 1 HUMAN|HGNC=19732|UniProtKB=P0CG22 P0CG22 DHRS4L1 PTHR43943:SF1 DEHYDROGENASE/REDUCTASE (SDR FAMILY) MEMBER 4 DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 4-LIKE 1-RELATED oxidoreductase activity#GO:0016491;alcohol dehydrogenase (NADP+) activity#GO:0008106;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;catalytic activity#GO:0003824;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 primary metabolic process#GO:0044238;aldehyde metabolic process#GO:0006081;cellular process#GO:0009987;retinoid metabolic process#GO:0001523;isoprenoid metabolic process#GO:0006720;diterpenoid metabolic process#GO:0016101;metabolic process#GO:0008152;olefinic compound metabolic process#GO:0120254;terpenoid metabolic process#GO:0006721;lipid metabolic process#GO:0006629 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;microbody#GO:0042579;peroxisome#GO:0005777;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=28152|UniProtKB=Q9BU64 Q9BU64 CENPO PTHR14582:SF1 INNER KINETOCHORE SUBUNIT MAL2 CENTROMERE PROTEIN O cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;supramolecular complex#GO:0099080;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;condensed chromosome, centromeric region#GO:0000779;chromosome#GO:0005694;kinetochore#GO:0000776;membraneless organelle#GO:0043228;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;chromosome, centromeric region#GO:0000775;condensed chromosome#GO:0000793;intracellular organelle#GO:0043229 HUMAN|HGNC=11106|UniProtKB=Q96GM5 Q96GM5 SMARCD1 PTHR13844:SF1 SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D MEMBER 1 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 catalytic complex#GO:1902494;intracellular organelle#GO:0043229;SWI/SNF complex#GO:0016514;ATPase complex#GO:1904949;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;SWI/SNF superfamily-type complex#GO:0070603;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;nucleus#GO:0005634;chromatin#GO:0000785;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991 chromatin/chromatin-binding, or -regulatory protein#PC00077 Wnt signaling pathway#P00057>SWI/SNF#P01435 HUMAN|HGNC=26110|UniProtKB=Q9BPY3 Q9BPY3 FAM118B PTHR28623:SF1 PROTEIN FAM118B PROTEIN FAM118B hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787;catalytic activity#GO:0003824 response to other organism#GO:0051707;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;defense response to other organism#GO:0098542;response to stimulus#GO:0050896;immune response#GO:0006955;defense response to symbiont#GO:0140546;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;defense response#GO:0006952;response to external stimulus#GO:0009605;innate immune response#GO:0045087;immune system process#GO:0002376 HUMAN|HGNC=18788|UniProtKB=P26718 P26718 KLRK1 PTHR47494:SF1 NKG2-D TYPE II INTEGRAL MEMBRANE PROTEIN NKG2-D TYPE II INTEGRAL MEMBRANE PROTEIN HUMAN|HGNC=27301|UniProtKB=Q53ET0 Q53ET0 CRTC2 PTHR13589:SF6 CREB-REGULATED TRANSCRIPTION COACTIVATOR CREB-REGULATED TRANSCRIPTION COACTIVATOR 2 protein binding#GO:0005515;transcription coactivator activity#GO:0003713;DNA-binding transcription factor binding#GO:0140297;transcription coregulator activity#GO:0003712;transcription factor binding#GO:0008134;binding#GO:0005488;transcription regulator activity#GO:0140110 positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;cellular response to nitrogen compound#GO:1901699;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular response to stimulus#GO:0051716;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;response to nitrogen compound#GO:1901698;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;cellular response to oxygen-containing compound#GO:1901701;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;response to chemical#GO:0042221;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;response to oxygen-containing compound#GO:1901700;cellular response to chemical stimulus#GO:0070887;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HUMAN|HGNC=21691|UniProtKB=P86791 P86791 CCZ1 PTHR13056:SF0 VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED guanyl-nucleotide exchange factor activity#GO:0005085;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772 establishment of localization in cell#GO:0051649;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;vacuolar transport#GO:0007034;transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641 cytoplasm#GO:0005737;protein-containing complex#GO:0032991;late endosome#GO:0005770;guanyl-nucleotide exchange factor complex#GO:0032045;endomembrane system#GO:0012505;intracellular protein-containing complex#GO:0140535;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular vesicle#GO:0097708;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;intracellular organelle#GO:0043229 HUMAN|HGNC=18175|UniProtKB=Q9NZJ6 Q9NZJ6 COQ3 PTHR43464:SF104 METHYLTRANSFERASE UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL transferase activity, transferring one-carbon groups#GO:0016741;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;O-methyltransferase activity#GO:0008171;transferase activity#GO:0016740;catalytic activity#GO:0003824 small molecule metabolic process#GO:0044281;biosynthetic process#GO:0009058;ketone metabolic process#GO:0042180;ubiquinone biosynthetic process#GO:0006744;ketone biosynthetic process#GO:0042181;cellular process#GO:0009987;metabolic process#GO:0008152;small molecule biosynthetic process#GO:0044283 mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 methyltransferase#PC00155;transferase#PC00220 HUMAN|HGNC=21596|UniProtKB=A0A8I5KW96 A0A8I5KW96 AK4P3 PTHR23359:SF58 NUCLEOTIDE KINASE ADENYLATE KINASE 4, MITOCHONDRIAL nucleoside diphosphate kinase activity#GO:0004550;phosphotransferase activity, phosphate group as acceptor#GO:0016776;catalytic activity#GO:0003824;transferase activity#GO:0016740;nucleobase-containing compound kinase activity#GO:0019205;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;nucleoside triphosphate metabolic process#GO:0009141;purine ribonucleoside monophosphate metabolic process#GO:0009167;nucleoside monophosphate metabolic process#GO:0009123;ribonucleotide metabolic process#GO:0009259;nucleotide metabolic process#GO:0009117;nucleoside triphosphate biosynthetic process#GO:0009142;organophosphate metabolic process#GO:0019637;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;nucleobase-containing small molecule metabolic process#GO:0055086;purine nucleoside monophosphate metabolic process#GO:0009126 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233 nucleotide kinase#PC00172;kinase#PC00137 De novo purine biosynthesis#P02738>Adenylate kinase#P02896 HUMAN|HGNC=4473|UniProtKB=Q15760 Q15760 GPR19 PTHR24243:SF224 G-PROTEIN COUPLED RECEPTOR G PROTEIN-COUPLED RECEPTOR 19-RELATED transmembrane signaling receptor activity#GO:0004888;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HUMAN|HGNC=20069|UniProtKB=Q9NVE5 Q9NVE5 USP40 PTHR24006:SF842 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 40 deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787;cysteine-type peptidase activity#GO:0008234;cysteine-type deubiquitinase activity#GO:0004843;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783 regulation of protein stability#GO:0031647;biological regulation#GO:0065007;regulation of biological quality#GO:0065008 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cytosol#GO:0005829;nucleus#GO:0005634 cysteine protease#PC00081;protease#PC00190 HUMAN|HGNC=224|UniProtKB=Q9UP79 Q9UP79 ADAMTS8 PTHR13723:SF41 ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 8 catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;metalloendopeptidase activity#GO:0004222;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233 external encapsulating structure organization#GO:0045229;protein metabolic process#GO:0019538;extracellular matrix organization#GO:0030198;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;extracellular structure organization#GO:0043062;proteolysis#GO:0006508;metabolic process#GO:0008152;cellular process#GO:0009987;cellular component organization#GO:0016043;primary metabolic process#GO:0044238 external encapsulating structure#GO:0030312;extracellular matrix#GO:0031012;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 HUMAN|HGNC=19368|UniProtKB=Q4G0P3 Q4G0P3 HYDIN PTHR23053:SF0 DLEC1 DELETED IN LUNG AND ESOPHAGEAL CANCER 1 AXONEMAL CENTRAL PAIR APPARATUS PROTEIN HYDIN microtubule bundle formation#GO:0001578;cilium movement#GO:0003341;organelle assembly#GO:0070925;cilium organization#GO:0044782;axoneme assembly#GO:0035082;microtubule cytoskeleton organization#GO:0000226;cilium assembly#GO:0060271;cellular component organization#GO:0016043;microtubule-based movement#GO:0007018;cell projection organization#GO:0030030;plasma membrane bounded cell projection assembly#GO:0120031;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;cilium#GO:0005929;axoneme#GO:0005930;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;ciliary plasm#GO:0097014;intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;cytoplasm#GO:0005737 HUMAN|HGNC=8810|UniProtKB=Q15119 Q15119 PDK2 PTHR11947:SF15 PYRUVATE DEHYDROGENASE KINASE [PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE ISOZYME 2, MITOCHONDRIAL protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 regulation of biosynthetic process#GO:0009889;regulation of lipid metabolic process#GO:0019216;regulation of carbohydrate metabolic process#GO:0006109;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 TCA cycle#P00051>Pyruvate Dehydrogenase#P01266 HUMAN|HGNC=8885|UniProtKB=P0DJD8 P0DJD8 PGA3 PTHR47966:SF22 BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED PEPSIN A-3-RELATED catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;catalytic activity#GO:0003824;aspartic-type endopeptidase activity#GO:0004190 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;cellular process#GO:0009987;proteolysis#GO:0006508;metabolic process#GO:0008152;primary metabolic process#GO:0044238 protease#PC00190;aspartic protease#PC00053 HUMAN|HGNC=16494|UniProtKB=Q9NRY7 Q9NRY7 PLSCR2 PTHR23248:SF29 PHOSPHOLIPID SCRAMBLASE-RELATED PHOSPHOLIPID SCRAMBLASE 2 intramembrane lipid carrier activity#GO:0140303;transporter activity#GO:0005215;phospholipid scramblase activity#GO:0017128;molecular carrier activity#GO:0140104;lipid carrier activity#GO:0005319 regulation of biological quality#GO:0065008;plasma membrane organization#GO:0007009;lipid localization#GO:0010876;regulation of biological process#GO:0050789;execution phase of apoptosis#GO:0097194;apoptotic process#GO:0006915;cellular component organization#GO:0016043;cellular component organization or biogenesis#GO:0071840;positive regulation of response to external stimulus#GO:0032103;endomembrane system organization#GO:0010256;regulation of response to external stimulus#GO:0032101;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of immune system process#GO:0002684;localization#GO:0051179;regulation of immune response#GO:0050776;regulation of defense response#GO:0031347;plasma membrane phospholipid scrambling#GO:0017121;lipid translocation#GO:0034204;regulation of response to biotic stimulus#GO:0002831;organophosphate ester transport#GO:0015748;regulation of immune system process#GO:0002682;cell death#GO:0008219;programmed cell death#GO:0012501;positive regulation of response to biotic stimulus#GO:0002833;regulation of membrane lipid distribution#GO:0097035;regulation of innate immune response#GO:0045088;establishment of localization#GO:0051234;positive regulation of defense response#GO:0031349;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;transport#GO:0006810;regulation of response to stress#GO:0080134;biological regulation#GO:0065007;membrane organization#GO:0061024;phospholipid transport#GO:0015914;phospholipid translocation#GO:0045332;lipid transport#GO:0006869;positive regulation of response to stimulus#GO:0048584;positive regulation of innate immune response#GO:0045089;macromolecule localization#GO:0033036 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227 HUMAN|HGNC=11433|UniProtKB=Q16623 Q16623 STX1A PTHR19957:SF84 SYNTAXIN SYNTAXIN-1A SNAP receptor activity#GO:0005484;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 organelle organization#GO:0006996;macromolecule localization#GO:0033036;membrane fusion#GO:0061025;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle fusion#GO:0048284;vesicle-mediated transport#GO:0016192;membrane organization#GO:0061024;organelle membrane fusion#GO:0090174;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;exocytosis#GO:0006887;intracellular protein localization#GO:0008104;vesicle organization#GO:0016050;cellular component organization#GO:0016043;vesicle fusion#GO:0006906;export from cell#GO:0140352;localization#GO:0051179;secretion#GO:0046903;cellular localization#GO:0051641;secretion by cell#GO:0032940;protein transport#GO:0015031 SNARE complex#GO:0031201;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;plasma membrane#GO:0005886;membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;intracellular anatomical structure#GO:0005622 SNARE protein#PC00034 Metabotropic glutamate receptor group II pathway#P00040>SNARE Complex#P01049;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>SNARE Complex#P01079;Metabotropic glutamate receptor group III pathway#P00039>SNARE Complex#P01042;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>SNARE Complex#P01066;Synaptic vesicle trafficking#P05734>Syntaxin 1/2#P05772;Nicotinic acetylcholine receptor signaling pathway#P00044>SNARE Complex#P01091 HUMAN|HGNC=939|UniProtKB=O95817 O95817 BAG3 PTHR12329:SF12 BCL2-ASSOCIATED ATHANOGENE BAG FAMILY MOLECULAR CHAPERONE REGULATOR 3 binding#GO:0005488;protein-folding chaperone binding#GO:0051087;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;protein binding#GO:0005515;molecular function regulator activity#GO:0098772 regulation of apoptotic process#GO:0042981;negative regulation of cellular process#GO:0048523;cellular homeostasis#GO:0019725;protein stabilization#GO:0050821;regulation of biological quality#GO:0065008;negative regulation of programmed cell death#GO:0043069;regulation of biological process#GO:0050789;regulation of protein stability#GO:0031647;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;homeostatic process#GO:0042592;biological regulation#GO:0065007;negative regulation of apoptotic process#GO:0043066;regulation of cellular process#GO:0050794 cytosol#GO:0005829;membrane#GO:0016020;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 chaperone#PC00072 Apoptosis signaling pathway#P00006>Bag#P00278 HUMAN|HGNC=33600|UniProtKB=P0C7N4 P0C7N4 TMEM191B PTHR38498:SF2 TRANSMEMBRANE PROTEIN 191B-RELATED TRANSMEMBRANE PROTEIN 191B HUMAN|HGNC=6244|UniProtKB=Q8WWG9 Q8WWG9 KCNE4 PTHR15282:SF9 POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY E MEMBER 1, 3 POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY E MEMBER 4 transmembrane transporter activity#GO:0022857;ion channel regulator activity#GO:0099106;passive transmembrane transporter activity#GO:0022803;molecular function regulator activity#GO:0098772;monoatomic cation channel activity#GO:0005261;transmembrane transporter binding#GO:0044325;transporter regulator activity#GO:0141108;potassium channel activity#GO:0005267;channel regulator activity#GO:0016247;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;transporter activity#GO:0005215;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;potassium channel regulator activity#GO:0015459;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;binding#GO:0005488;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;protein binding#GO:0005515 transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;export from cell#GO:0140352;heart process#GO:0003015;muscle system process#GO:0003012;regulation of biological process#GO:0050789;action potential#GO:0001508;regulation of membrane potential#GO:0042391;cardiac muscle cell action potential involved in contraction#GO:0086002;regulation of multicellular organismal process#GO:0051239;monoatomic cation transmembrane transport#GO:0098655;cellular process#GO:0009987;localization#GO:0051179;monoatomic cation transport#GO:0006812;circulatory system process#GO:0003013;actin filament-based process#GO:0030029;cardiac muscle contraction#GO:0060048;actin-mediated cell contraction#GO:0070252;regulation of heart contraction#GO:0008016;striated muscle contraction#GO:0006941;metal ion transport#GO:0030001;establishment of localization#GO:0051234;cardiac muscle cell contraction#GO:0086003;system process#GO:0003008;heart contraction#GO:0060047;regulation of system process#GO:0044057;transport#GO:0006810;muscle contraction#GO:0006936;multicellular organismal process#GO:0032501;blood circulation#GO:0008015;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;potassium ion transmembrane transport#GO:0071805;biological regulation#GO:0065007;actin filament-based movement#GO:0030048 cation channel complex#GO:0034703;voltage-gated potassium channel complex#GO:0008076;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702 voltage-gated ion channel#PC00241 HUMAN|HGNC=26665|UniProtKB=Q8NA57 Q8NA57 C12orf50 PTHR15725:SF1 ZN-FINGER, C-X8-C-X5-C-X3-H TYPE-CONTAINING RIKEN CDNA 1700017N19 GENE mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 biosynthetic process#GO:0009058;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;establishment of localization in cell#GO:0051649;nitrogen compound transport#GO:0071705;macromolecule localization#GO:0033036;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;poly(A)+ mRNA export from nucleus#GO:0016973;transport#GO:0006810;intracellular transport#GO:0046907;RNA export from nucleus#GO:0006405;metabolic process#GO:0008152;establishment of RNA localization#GO:0051236;mRNA transport#GO:0051028;RNA localization#GO:0006403;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;nuclear export#GO:0051168;nuclear transport#GO:0051169;mRNA export from nucleus#GO:0006406;nucleic acid transport#GO:0050657;cellular localization#GO:0051641;localization#GO:0051179;nucleocytoplasmic transport#GO:0006913 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 RNA processing factor#PC00147 HUMAN|HGNC=16388|UniProtKB=Q9BZF3 Q9BZF3 OSBPL6 PTHR10972:SF76 OXYSTEROL-BINDING PROTEIN-RELATED OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 6 sterol binding#GO:0032934;binding#GO:0005488;small molecule binding#GO:0036094;cholesterol binding#GO:0015485;steroid binding#GO:0005496;lipid binding#GO:0008289;alcohol binding#GO:0043178 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;nuclear membrane#GO:0031965;organelle membrane#GO:0031090;endoplasmic reticulum#GO:0005783;endomembrane system#GO:0012505;perinuclear region of cytoplasm#GO:0048471;nuclear envelope#GO:0005635;plasma membrane#GO:0005886;cytoplasm#GO:0005737;cytosol#GO:0005829;membrane#GO:0016020;cell periphery#GO:0071944;nucleus#GO:0005634 transfer/carrier protein#PC00219 HUMAN|HGNC=30096|UniProtKB=Q9Y3B4 Q9Y3B4 SF3B6 PTHR48526:SF2 SPLICING FACTOR 3B SUBUNIT 6 SPLICING FACTOR 3B SUBUNIT 6 HUMAN|HGNC=6283|UniProtKB=Q9NPC2 Q9NPC2 KCNK9 PTHR11003:SF75 POTASSIUM CHANNEL, SUBFAMILY K POTASSIUM CHANNEL SUBFAMILY K MEMBER 9 monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated monoatomic ion channel activity#GO:0005244;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;transporter activity#GO:0005215;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;outward rectifier potassium channel activity#GO:0015271;potassium channel activity#GO:0005267;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803 transport#GO:0006810;potassium ion import across plasma membrane#GO:1990573;import into cell#GO:0098657;establishment of localization#GO:0051234;inorganic cation import across plasma membrane#GO:0098659;cellular process#GO:0009987;potassium ion transport#GO:0006813;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;monoatomic ion transmembrane transport#GO:0034220;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;import across plasma membrane#GO:0098739;metal ion transport#GO:0030001;inorganic ion import across plasma membrane#GO:0099587 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227;ion channel#PC00133 5HT3 type receptor mediated signaling pathway#P04375>K+ channel#P04425;Dopamine receptor mediated signaling pathway#P05912>K+ channel#P05957;Opioid proenkephalin pathway#P05915>K+ channel#P05990;Nicotine pharmacodynamics pathway#P06587>KCNK3/9#P06605;5HT4 type receptor mediated signaling pathway#P04376>K+ channel#P04426;Opioid proopiomelanocortin pathway#P05917>K+ channel#P06009;5HT1 type receptor mediated signaling pathway#P04373>K+ channel#P04407;5HT2 type receptor mediated signaling pathway#P04374>K+ channel#P04413 HUMAN|HGNC=28871|UniProtKB=Q9BTL4 Q9BTL4 IER2 PTHR15895:SF4 IMMEDIATE EARLY RESPONSE GENE IMMEDIATE EARLY RESPONSE GENE 2 PROTEIN HUMAN|HGNC=37181|UniProtKB=P0C7I0 P0C7I0 USP17L8 PTHR24006:SF651 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE INACTIVE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 17-LIKE PROTEIN 4-RELATED hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;cysteine-type peptidase activity#GO:0008234;cysteine-type deubiquitinase activity#GO:0004843;catalytic activity#GO:0003824 regulation of biological quality#GO:0065008;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of apoptotic process#GO:0042981;regulation of protein stability#GO:0031647;regulation of biological process#GO:0050789;regulation of programmed cell death#GO:0043067 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cytosol#GO:0005829;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 protease#PC00190;cysteine protease#PC00081 HUMAN|HGNC=11914|UniProtKB=Q9Y5U5 Q9Y5U5 TNFRSF18 PTHR47388:SF1 TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 18 TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 18 positive regulation of cell adhesion#GO:0045785;regulation of biological process#GO:0050789;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of cell adhesion#GO:0030155 membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=21755|UniProtKB=Q8NET6 Q8NET6 CHST13 PTHR12137:SF60 CARBOHYDRATE SULFOTRANSFERASE CARBOHYDRATE SULFOTRANSFERASE 13 transferase activity, transferring sulphur-containing groups#GO:0016782;sulfotransferase activity#GO:0008146;transferase activity#GO:0016740;catalytic activity#GO:0003824 glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;proteoglycan metabolic process#GO:0006029;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;carbohydrate derivative metabolic process#GO:1901135;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;proteoglycan biosynthetic process#GO:0030166;biosynthetic process#GO:0009058 transferase#PC00220 HUMAN|HGNC=10904|UniProtKB=Q14493 Q14493 SLBP PTHR17408:SF7 HISTONE RNA HAIRPIN-BINDING PROTEIN HISTONE RNA HAIRPIN-BINDING PROTEIN RNA binding#GO:0003723;pre-mRNA binding#GO:0036002;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729 nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;nucleic acid transport#GO:0050657;localization#GO:0051179;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA metabolic process#GO:0016071;establishment of RNA localization#GO:0051236;RNA biosynthetic process#GO:0032774;mRNA transport#GO:0051028;RNA localization#GO:0006403;RNA transport#GO:0050658;nucleobase-containing compound transport#GO:0015931;transport#GO:0006810;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;mRNA 3'-end processing#GO:0031124;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;nitrogen compound transport#GO:0071705;macromolecule localization#GO:0033036;mRNA processing#GO:0006397;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634 RNA metabolism protein#PC00031 HUMAN|HGNC=17190|UniProtKB=Q6UX06 Q6UX06 OLFM4 PTHR23192:SF7 OLFACTOMEDIN-RELATED OLFACTOMEDIN-4 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 structural protein#PC00211 HUMAN|HGNC=16306|UniProtKB=Q96B70 Q96B70 LENG9 PTHR46729:SF1 LEUKOCYTE RECEPTOR CLUSTER MEMBER 9 LEUKOCYTE RECEPTOR CLUSTER MEMBER 9 HUMAN|HGNC=19013|UniProtKB=Q8WV44 Q8WV44 TRIM41 PTHR24103:SF713 E3 UBIQUITIN-PROTEIN LIGASE TRIM E3 UBIQUITIN-PROTEIN LIGASE TRIM41 aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746 defense response#GO:0006952;response to external stimulus#GO:0009605;innate immune response#GO:0045087;immune system process#GO:0002376;response to other organism#GO:0051707;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;defense response to other organism#GO:0098542;response to stimulus#GO:0050896;defense response to symbiont#GO:0140546;immune response#GO:0006955;response to stress#GO:0006950;response to biotic stimulus#GO:0009607 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=9208|UniProtKB=P16435 P16435 POR PTHR19384:SF17 NITRIC OXIDE SYNTHASE-RELATED NADPH--CYTOCHROME P450 REDUCTASE catalytic activity#GO:0003824;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;oxidoreductase activity#GO:0016491;heterocyclic compound binding#GO:1901363;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;binding#GO:0005488;flavin adenine dinucleotide binding#GO:0050660;anion binding#GO:0043168;nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167;oxidoreductase activity, acting on NAD(P)H#GO:0016651 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 Vitamin D metabolism and pathway#P04396>P450 reductase#P04605 HUMAN|HGNC=11012|UniProtKB=Q9Y6M5 Q9Y6M5 SLC30A1 PTHR45820:SF1 FI23527P1 PROTON-COUPLED ZINC ANTIPORTER SLC30A1 molecular function regulator activity#GO:0098772;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;ion channel regulator activity#GO:0099106;calcium channel regulator activity#GO:0005246;ion channel inhibitor activity#GO:0008200;zinc ion transmembrane transporter activity#GO:0005385;molecular function inhibitor activity#GO:0140678;channel regulator activity#GO:0016247;monoatomic cation transmembrane transporter activity#GO:0008324;transporter regulator activity#GO:0141108;transition metal ion transmembrane transporter activity#GO:0046915 transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;intracellular monoatomic cation homeostasis#GO:0030003;response to metal ion#GO:0010038;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;establishment of localization#GO:0051234;cellular process#GO:0009987;detoxification of inorganic compound#GO:0061687;monoatomic ion homeostasis#GO:0050801;response to stress#GO:0006950;zinc ion transport#GO:0006829;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;detoxification#GO:0098754;response to chemical#GO:0042221;transition metal ion transport#GO:0000041;inorganic ion homeostasis#GO:0098771;zinc ion transmembrane transport#GO:0071577;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;intracellular monoatomic ion homeostasis#GO:0006873;metal ion transport#GO:0030001;homeostatic process#GO:0042592;response to toxic substance#GO:0009636;response to stimulus#GO:0050896 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;membrane#GO:0016020 HUMAN|HGNC=22231|UniProtKB=Q400G9 Q400G9 AMZ1 PTHR32205:SF4 ARCHAEMETZINCIN-2-RELATED ARCHAEMETZINCIN-1 HUMAN|HGNC=24284|UniProtKB=Q8WVT3 Q8WVT3 TRAPPC12 PTHR21581:SF34 D-ALANYL-D-ALANINE CARBOXYPEPTIDASE TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 12 organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;TRAPP complex#GO:0030008;vesicle tethering complex#GO:0099023;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 protease#PC00190;serine protease#PC00203 HUMAN|HGNC=7683|UniProtKB=O15239 O15239 NDUFA1 PTHR17098:SF2 NADH-UBIQUINONE OXIDOREDUCTASE MWFE SUBUNIT NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 1 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;membrane#GO:0016020;oxidoreductase complex#GO:1990204;membrane protein complex#GO:0098796;respiratory chain complex#GO:0098803;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;respiratory chain complex I#GO:0045271;catalytic complex#GO:1902494 oxidoreductase#PC00176 HUMAN|HGNC=26990|UniProtKB=Q86WR6 Q86WR6 CHCT1 PTHR21765:SF1 SIMILAR TO CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1 (CHD-1) CHD1 HELICAL C-TERMINAL DOMAIN CONTAINING PROTEIN 1 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=14037|UniProtKB=Q96A35 Q96A35 MRPL24 PTHR12903:SF0 MITOCHONDRIAL RIBOSOMAL PROTEIN L24 LARGE RIBOSOMAL SUBUNIT PROTEIN UL24M gene expression#GO:0010467;protein biosynthetic process#GO:0160307;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;translation#GO:0006412 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 ribosomal protein#PC00202 HUMAN|HGNC=17182|UniProtKB=Q9H672 Q9H672 ASB7 PTHR24118:SF102 POTE ANKYRIN DOMAIN ANKYRIN REPEAT AND SOCS BOX PROTEIN 7 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;enzyme-substrate adaptor activity#GO:0140767;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;biological regulation#GO:0065007;proteasomal protein catabolic process#GO:0010498;cellular process#GO:0009987;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;regulation of chromatin organization#GO:1902275;catabolic process#GO:0009056;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;modification-dependent protein catabolic process#GO:0019941 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cullin-RING ubiquitin ligase complex#GO:0031461;chromosome#GO:0005694;ubiquitin ligase complex#GO:0000151;Cul5-RING ubiquitin ligase complex#GO:0031466;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;chromatin#GO:0000785;heterochromatin#GO:0000792;membraneless organelle#GO:0043228;intracellular protein-containing complex#GO:0140535;transferase complex#GO:1990234 membrane traffic protein#PC00150 HUMAN|HGNC=7411|UniProtKB=O94776 O94776 MTA2 PTHR10865:SF4 METASTASIS-ASSOCIATED PROTEIN AND MESODERM INDUCTION EARLY RESPONSE PROTEIN METASTASIS-ASSOCIATED PROTEIN MTA2 transcription coactivator activity#GO:0003713;histone deacetylase binding#GO:0042826;transcription coregulator activity#GO:0003712;transcription corepressor activity#GO:0003714;protein binding#GO:0005515;binding#GO:0005488;enzyme binding#GO:0019899;transcription regulator activity#GO:0140110 negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;SWI/SNF superfamily-type complex#GO:0070603;chromosome#GO:0005694;organelle lumen#GO:0043233;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;ATPase complex#GO:1904949;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;chromatin#GO:0000785;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;histone deacetylase complex#GO:0000118;transcription regulator complex#GO:0005667;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 p53 pathway#P00059>MTA2#P04615 HUMAN|HGNC=17820|UniProtKB=Q9H0P0 Q9H0P0 NT5C3A PTHR13045:SF14 5'-NUCLEOTIDASE CYTOSOLIC 5'-NUCLEOTIDASE 3A hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;5'-nucleotidase activity#GO:0008253;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;nucleotidase activity#GO:0008252 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 esterase#PC00097;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=4484|UniProtKB=P46089 P46089 GPR3 PTHR22750:SF39 G-PROTEIN COUPLED RECEPTOR G PROTEIN-COUPLED RECEPTOR 3 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888;bioactive lipid receptor activity#GO:0045125 cell communication#GO:0007154;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021 HUMAN|HGNC=18696|UniProtKB=Q96RK1 Q96RK1 CITED4 PTHR17045:SF5 MELANOCYTE SPECIFIC GENE RELATED CITED CBP_P300-INTERACTING TRANSACTIVATOR 4 transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;transcription coactivator activity#GO:0003713 response to endogenous stimulus#GO:0009719;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;regulation of DNA-templated transcription#GO:0006355;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule biosynthetic process#GO:0010556;response to hormone#GO:0009725;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of DNA-templated transcription#GO:0045893;response to chemical#GO:0042221;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 transcription cofactor#PC00217;gene-specific transcriptional regulator#PC00264 TGF-beta signaling pathway#P00052>Co-activators corepressors#P01282 HUMAN|HGNC=18758|UniProtKB=Q8IWZ6 Q8IWZ6 BBS7 PTHR16074:SF4 BARDET-BIEDL SYNDROME 7 PROTEIN BBSOME COMPLEX MEMBER BBS7 plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cell projection assembly#GO:0030031;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;macromolecule localization#GO:0033036;intracellular protein localization#GO:0008104;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;transport#GO:0006810;plasma membrane bounded cell projection assembly#GO:0120031;intracellular transport#GO:0046907;cell projection organization#GO:0030030;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cilium organization#GO:0044782;localization#GO:0051179;cellular localization#GO:0051641;organelle assembly#GO:0070925 cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;axoneme#GO:0005930;intracellular organelle#GO:0043229;cilium#GO:0005929;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;BBSome#GO:0034464;protein-containing complex#GO:0032991;ciliary plasm#GO:0097014;neuron projection#GO:0043005;microtubule cytoskeleton#GO:0015630;membrane#GO:0016020;membraneless organelle#GO:0043228;microtubule organizing center#GO:0005815;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856 HUMAN|HGNC=19884|UniProtKB=Q9UJC3 Q9UJC3 HOOK1 PTHR18947:SF36 HOOK PROTEINS PROTEIN HOOK HOMOLOG 1 protein binding#GO:0005515;binding#GO:0005488;microtubule binding#GO:0008017;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092 microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;transport#GO:0006810;intracellular transport#GO:0046907;cytoskeleton organization#GO:0007010;cytoskeleton-dependent intracellular transport#GO:0030705;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;localization#GO:0051179;cellular localization#GO:0051641;microtubule cytoskeleton organization#GO:0000226;cytoplasmic microtubule organization#GO:0031122;cellular component organization#GO:0016043 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;centrosome#GO:0005813;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;microtubule cytoskeleton#GO:0015630 membrane traffic protein#PC00150 HUMAN|HGNC=18173|UniProtKB=Q9NZ08 Q9NZ08 ERAP1 PTHR11533:SF156 PROTEASE M1 ZINC METALLOPROTEASE ENDOPLASMIC RETICULUM AMINOPEPTIDASE 1 catalytic activity#GO:0003824;aminopeptidase activity#GO:0004177;metalloexopeptidase activity#GO:0008235;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;metallopeptidase activity#GO:0008237;exopeptidase activity#GO:0008238;hydrolase activity#GO:0016787;metalloaminopeptidase activity#GO:0070006 primary metabolic process#GO:0044238;peptide catabolic process#GO:0043171;cellular process#GO:0009987;catabolic process#GO:0009056;proteolysis#GO:0006508;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;peptide metabolic process#GO:0006518 metalloprotease#PC00153;protease#PC00190 HUMAN|HGNC=6864|UniProtKB=Q12851 Q12851 MAP4K2 PTHR48012:SF6 STERILE20-LIKE KINASE, ISOFORM B-RELATED MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 2 transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 Apoptosis signaling pathway#P00006>GCK#P00268;Gonadotropin-releasing hormone receptor pathway#P06664>MAP4Ks#P06861 HUMAN|HGNC=33108|UniProtKB=Q6NX45 Q6NX45 ZNF774 PTHR24377:SF924 IP01015P-RELATED ZINC FINGER PROTEIN 774 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=4248|UniProtKB=Q92820 Q92820 GGH PTHR11315:SF20 PROTEASE FAMILY C26 GAMMA-GLUTAMYL HYDROLASE GAMMA-GLUTAMYL HYDROLASE cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787 pteridine-containing compound metabolic process#GO:0042558;folic acid-containing compound metabolic process#GO:0006760;modified amino acid metabolic process#GO:0006575;metabolic process#GO:0008152;cellular process#GO:0009987 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;vacuole#GO:0005773;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 cysteine protease#PC00081;protease#PC00190 HUMAN|HGNC=17224|UniProtKB=O75154 O75154 RAB11FIP3 PTHR15726:SF6 RAB11-FAMILY INTERACTING PROTEIN RAB11 FAMILY-INTERACTING PROTEIN 3 regulation of cell division#GO:0051302;regulation of cytokinesis#GO:0032465;localization within membrane#GO:0051668;cellular localization#GO:0051641;localization#GO:0051179;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;endocytic recycling#GO:0032456;regulation of cell cycle#GO:0051726;intracellular transport#GO:0046907;transport#GO:0006810;establishment of localization#GO:0051234;vesicle-mediated transport to the plasma membrane#GO:0098876;endosomal transport#GO:0016197;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;biological regulation#GO:0065007;regulation of cell cycle process#GO:0010564 cell division site#GO:0032153;plasma membrane#GO:0005886;cytoplasm#GO:0005737;plasma membrane region#GO:0098590;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;cell periphery#GO:0071944;vesicle membrane#GO:0012506;membrane#GO:0016020;bounding membrane of organelle#GO:0098588;recycling endosome membrane#GO:0055038;organelle membrane#GO:0031090;cleavage furrow#GO:0032154;recycling endosome#GO:0055037;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;midbody#GO:0030496;membrane-bounded organelle#GO:0043227;endocytic vesicle#GO:0030139;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endosome membrane#GO:0010008;endosome#GO:0005768 HUMAN|HGNC=6937|UniProtKB=Q9HCC0 Q9HCC0 MCCC2 PTHR22855:SF13 ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED METHYLCROTONOYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL ligase activity#GO:0016874;catalytic activity#GO:0003824 carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;cellular process#GO:0009987;carboxylic acid catabolic process#GO:0046395;proteinogenic amino acid metabolic process#GO:0170039;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;small molecule catabolic process#GO:0044282;amino acid metabolic process#GO:0006520;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 ligase#PC00142;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=22999|UniProtKB=Q6UXY8 Q6UXY8 TMC5 PTHR23302:SF5 TRANSMEMBRANE CHANNEL-RELATED TRANSMEMBRANE CHANNEL-LIKE PROTEIN 5 monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;gated channel activity#GO:0022836;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 ion channel#PC00133 HUMAN|HGNC=26162|UniProtKB=Q8WU10 Q8WU10 PYROXD1 PTHR43429:SF2 PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASE DOMAIN-CONTAINING TRNA LIGASE COMPLEX-ASSOCIATED NAD(P)H DEHYDROGENASE PYROXD1 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=12492|UniProtKB=P61088 P61088 UBE2N PTHR24068:SF540 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2 N ubiquitin conjugating enzyme activity#GO:0061631;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-like protein conjugating enzyme activity#GO:0061650;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787 DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA damage tolerance#GO:0006301;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;protein K63-linked ubiquitination#GO:0070534;response to stress#GO:0006950;cellular process#GO:0009987;post-translational protein modification#GO:0043687;nucleobase-containing compound metabolic process#GO:0006139;protein ubiquitination#GO:0016567;protein modification by small protein conjugation or removal#GO:0070647;cellular response to stress#GO:0033554;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;protein modification process#GO:0036211;cellular response to stimulus#GO:0051716;DNA replication#GO:0006260;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;response to stimulus#GO:0050896 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 ubiquitin-protein ligase#PC00234 Toll receptor signaling pathway#P00054>Ubc13#P01381;Ubiquitin proteasome pathway#P00060>E2#P01491 HUMAN|HGNC=17597|UniProtKB=Q9UBB6 Q9UBB6 NCDN PTHR13109:SF8 NEUROCHONDRIN NEUROCHONDRIN cellular process#GO:0009987;neuron projection development#GO:0031175;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;regulation of trans-synaptic signaling#GO:0099177;neuron differentiation#GO:0030182;developmental process#GO:0032502;regulation of synaptic plasticity#GO:0048167;neurogenesis#GO:0022008;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;regulation of neuronal synaptic plasticity#GO:0048168;cellular developmental process#GO:0048869;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;modulation of chemical synaptic transmission#GO:0050804;regulation of cell communication#GO:0010646;cell development#GO:0048468;cell projection organization#GO:0030030;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;generation of neurons#GO:0048699;regulation of signaling#GO:0023051;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;regulation of biological quality#GO:0065008;neuron development#GO:0048666;anatomical structure development#GO:0048856 dendrite#GO:0030425;dendritic tree#GO:0097447;neuron projection#GO:0043005;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;somatodendritic compartment#GO:0036477;plasma membrane bounded cell projection#GO:0120025 scaffold/adaptor protein#PC00226 HUMAN|HGNC=20259|UniProtKB=Q9Y2K1 Q9Y2K1 ZBTB1 PTHR24399:SF21 ZINC FINGER AND BTB DOMAIN-CONTAINING ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 1 sequence-specific DNA binding#GO:0043565;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;DNA-binding transcription repressor activity#GO:0001217;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription repressor activity, RNA polymerase II-specific#GO:0001227;transcription cis-regulatory region binding#GO:0000976;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;regulation of multicellular organismal process#GO:0051239;regulation of cytokine production#GO:0001817;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233 C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218 HUMAN|HGNC=21020|UniProtKB=Q9H0R6 Q9H0R6 QRSL1 PTHR11895:SF153 TRANSAMIDASE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A, MITOCHONDRIAL catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;ligase activity#GO:0016874;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098;ligase activity, forming carbon-nitrogen bonds#GO:0016879 protein metabolic process#GO:0019538;RNA metabolic process#GO:0016070;mitochondrial gene expression#GO:0140053;translation#GO:0006412;mitochondrial translation#GO:0032543;protein biosynthetic process#GO:0160307;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;amino acid activation#GO:0043038;macromolecule metabolic process#GO:0043170;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;gene expression#GO:0010467;amino acid metabolic process#GO:0006520;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;tRNA aminoacylation#GO:0043039;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 ligase#PC00142;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=20748|UniProtKB=Q9NW38 Q9NW38 FANCL PTHR13206:SF0 UBIQUITIN LIGASE PROTEIN PHF9 FANCONI ANEMIA GROUP L PROTEIN E3 UBIQUITIN-PROTEIN LIGASE FANCL catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659 post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;nucleobase-containing compound metabolic process#GO:0006139;response to stress#GO:0006950;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA damage response#GO:0006974;response to stimulus#GO:0050896;protein modification process#GO:0036211;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular response to stimulus#GO:0051716;protein modification by small protein conjugation#GO:0032446;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein modification by small protein conjugation or removal#GO:0070647;cellular response to stress#GO:0033554 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|Ensembl=ENSG00000282168.4|UniProtKB=A0A499FJF3 A0A499FJF3 PTHR15670:SF4 RHO GTPASE ACTIVATING PROTEIN 11A INACTIVE RHO GTPASE-ACTIVATING PROTEIN 11B-RELATED enzyme activator activity#GO:0008047;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096 GTPase-activating protein#PC00257 HUMAN|HGNC=12217|UniProtKB=A0A589 A0A589 TRBV4-3 PTHR23268:SF98 T-CELL RECEPTOR BETA CHAIN T CELL RECEPTOR BETA VARIABLE 4-3 biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=11596|UniProtKB=O60806 O60806 TBX19 PTHR11267:SF114 T-BOX PROTEIN-RELATED T-BOX TRANSCRIPTION FACTOR TBX19 transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 heart development#GO:0007507;embryo development#GO:0009790;cellular process#GO:0009987;embryonic morphogenesis#GO:0048598;multicellular organism development#GO:0007275;mesoderm development#GO:0007498;animal organ development#GO:0048513;anatomical structure formation involved in morphogenesis#GO:0048646;cell fate specification#GO:0001708;cell differentiation#GO:0030154;circulatory system development#GO:0072359;regulation of transcription by RNA polymerase II#GO:0006357;gastrulation#GO:0007369;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;cell fate commitment#GO:0045165;animal gross anatomical part developmental process#GO:0160108;formation of primary germ layer#GO:0001704;mesoderm formation#GO:0001707;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;tissue development#GO:0009888;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;developmental process#GO:0032502;regulation of macromolecule metabolic process#GO:0060255;animal organ morphogenesis#GO:0009887;regulation of cellular process#GO:0050794;heart morphogenesis#GO:0003007;mesoderm morphogenesis#GO:0048332;tissue morphogenesis#GO:0048729;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252 intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;chromatin#GO:0000785;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229 Rel homology transcription factor#PC00252;immunoglobulin fold transcription factor#PC00251 HUMAN|HGNC=1333|UniProtKB=Q9NRY5 Q9NRY5 FAM114A2 PTHR12842:SF3 FI01459P PROTEIN FAM114A2 HUMAN|HGNC=7776|UniProtKB=Q13469 Q13469 NFATC2 PTHR12533:SF4 NFAT NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2 DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 positive regulation of macromolecule metabolic process#GO:0010604;intracellular signaling cassette#GO:0141124;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;signaling#GO:0023052;regulation of biological process#GO:0050789;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;regulation of biosynthetic process#GO:0009889;calcium-mediated signaling#GO:0019722;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;calcineurin-mediated signaling#GO:0097720;calcineurin-NFAT signaling cascade#GO:0033173;cellular response to stimulus#GO:0051716;regulation of DNA-templated transcription#GO:0006355;cell communication#GO:0007154;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;intracellular signal transduction#GO:0035556 transcription regulator complex#GO:0005667;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;Rel homology transcription factor#PC00252;immunoglobulin fold transcription factor#PC00251 Axon guidance mediated by netrin#P00009>NFAT#P00359;T cell activation#P00053>NFAT#P01294;B cell activation#P00010>NFAT#P00367;Wnt signaling pathway#P00057>NFAT#P01452;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>NFAT#P00851;Gonadotropin-releasing hormone receptor pathway#P06664>NFAT#P06777;CCKR signaling map#P06959>NFAT1#P07176 HUMAN|HGNC=30590|UniProtKB=O95807 O95807 TMEM50A PTHR13180:SF4 SMALL MEMBRANE PROTEIN-RELATED TRANSMEMBRANE PROTEIN 50A vesicle-mediated transport#GO:0016192;cytosolic transport#GO:0016482;retrograde transport, endosome to Golgi#GO:0042147;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;endosomal transport#GO:0016197;intracellular transport#GO:0046907;transport#GO:0006810 membrane#GO:0016020;vesicle membrane#GO:0012506;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;endosome#GO:0005768;endosome membrane#GO:0010008;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=24031|UniProtKB=Q9HBM1 Q9HBM1 SPC25 PTHR14281:SF0 KINETOCHORE PROTEIN SPC25-RELATED KINETOCHORE PROTEIN SPC25 chromosome segregation#GO:0007059;cellular process#GO:0009987;cell cycle process#GO:0022402;cell cycle#GO:0007049 membraneless organelle#GO:0043228;outer kinetochore#GO:0000940;intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687;condensed chromosome#GO:0000793;chromosome, centromeric region#GO:0000775;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232;condensed chromosome, centromeric region#GO:0000779;chromosome#GO:0005694;kinetochore#GO:0000776 HUMAN|HGNC=9539|UniProtKB=P49721 P49721 PSMB2 PTHR11599:SF6 PROTEASOME SUBUNIT ALPHA/BETA PROTEASOME SUBUNIT BETA TYPE-2 ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238 intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;endopeptidase complex#GO:1905369;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;peptidase complex#GO:1905368;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;proteasome complex#GO:0000502;cytosol#GO:0005829 protein modifying enzyme#PC00260;protease#PC00190 HUMAN|HGNC=9867|UniProtKB=P49788 P49788 RARRES1 PTHR28591:SF2 LATEXIN RETINOIC ACID RECEPTOR RESPONDER PROTEIN 1 enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414;peptidase regulator activity#GO:0061134;endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772;enzyme inhibitor activity#GO:0004857 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HUMAN|HGNC=16226|UniProtKB=Q5TG30 Q5TG30 ARHGAP40 PTHR14963:SF4 RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED RHO GTPASE-ACTIVATING PROTEIN 40 enzyme activator activity#GO:0008047;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772 regulation of cell communication#GO:0010646;regulation of cellular component biogenesis#GO:0044087;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;regulation of protein polymerization#GO:0032271;regulation of cellular process#GO:0050794;regulation of cellular component size#GO:0032535;regulation of biological process#GO:0050789;regulation of supramolecular fiber organization#GO:1902903;regulation of organelle organization#GO:0033043;cellular component organization#GO:0016043;regulation of protein-containing complex assembly#GO:0043254;regulation of biological quality#GO:0065008;regulation of actin filament length#GO:0030832;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;regulation of signal transduction#GO:0009966;regulation of actin polymerization or depolymerization#GO:0008064;biological regulation#GO:0065007;regulation of actin cytoskeleton organization#GO:0032956;regulation of actin filament polymerization#GO:0030833;regulation of actin filament organization#GO:0110053;cellular process#GO:0009987;regulation of small GTPase mediated signal transduction#GO:0051056;cellular component organization or biogenesis#GO:0071840;regulation of response to stimulus#GO:0048583;regulation of anatomical structure size#GO:0090066;regulation of actin filament-based process#GO:0032970 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 GTPase-activating protein#PC00257;G-protein modulator#PC00022 HUMAN|HGNC=34350|UniProtKB=A6NN90 A6NN90 C2orf81 PTHR34438:SF1 SI:DKEY-97L20.6 CHROMOSOME 2 OPEN READING FRAME 81 HUMAN|HGNC=26019|UniProtKB=Q9NX62 Q9NX62 BPNT2 PTHR43028:SF6 3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1 GOLGI-RESIDENT ADENOSINE 3',5'-BISPHOSPHATE 3'-PHOSPHATASE hydrolase activity#GO:0016787;phosphoric ester hydrolase activity#GO:0042578;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;nucleotidase activity#GO:0008252;catalytic activity#GO:0003824 developmental process#GO:0032502;connective tissue development#GO:0061448;cellular developmental process#GO:0048869;animal organ development#GO:0048513;multicellular organism development#GO:0007275;cellular process#GO:0009987;tissue development#GO:0009888;chondrocyte differentiation#GO:0002062;multicellular organismal process#GO:0032501;animal gross anatomical part developmental process#GO:0160108;cartilage development#GO:0051216;system development#GO:0048731;anatomical structure development#GO:0048856;skeletal system development#GO:0001501;cell development#GO:0048468;cell differentiation#GO:0030154 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229 phosphatase#PC00181;hydrolase#PC00121 HUMAN|HGNC=703|UniProtKB=Q92747 Q92747 ARPC1A PTHR10709:SF11 ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1 ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 1A cortical actin cytoskeleton organization#GO:0030866;cellular component organization or biogenesis#GO:0071840;supramolecular fiber organization#GO:0097435;actin filament organization#GO:0007015;cortical cytoskeleton organization#GO:0030865;actin filament-based process#GO:0030029;actin cytoskeleton organization#GO:0030036;actin nucleation#GO:0045010;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;Arp2/3 complex-mediated actin nucleation#GO:0034314 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membraneless organelle#GO:0043232;actin cytoskeleton#GO:0015629;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;Arp2/3 protein complex#GO:0005885;intracellular organelle#GO:0043229 actin or actin-binding cytoskeletal protein#PC00041 Huntington disease#P00029>Arp2/3 complex#P00811;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Arp2/3#P00876;Cytoskeletal regulation by Rho GTPase#P00016>ARP2/3#P00511;Integrin signalling pathway#P00034>Arp2/3#P00912 HUMAN|HGNC=30257|UniProtKB=Q9BRQ0 Q9BRQ0 PYGO2 PTHR23194:SF7 PYGOPUS PYGOPUS HOMOLOG 2 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription coactivator activity#GO:0003713 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;signal transduction#GO:0007165;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cell surface receptor signaling pathway#GO:0007166;signaling#GO:0023052;regulation of macromolecule metabolic process#GO:0060255;Wnt signaling pathway#GO:0016055;response to stimulus#GO:0050896;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;regulation of RNA metabolic process#GO:0051252;canonical Wnt signaling pathway#GO:0060070;cell communication#GO:0007154;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 Wnt signaling pathway#P00057>Pygo#P01464 HUMAN|HGNC=3234|UniProtKB=Q9H1U4 Q9H1U4 MEGF9 PTHR10574:SF298 NETRIN/LAMININ-RELATED MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN 9 extracellular matrix assembly#GO:0085029;cell migration#GO:0016477;tissue development#GO:0009888;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;axon guidance#GO:0007411;axon development#GO:0061564;cellular developmental process#GO:0048869;neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;cell motility#GO:0048870;cell-substrate adhesion#GO:0031589;extracellular matrix organization#GO:0030198;anatomical structure development#GO:0048856;external encapsulating structure organization#GO:0045229;system development#GO:0048731;cellular component assembly#GO:0022607;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;neuron projection development#GO:0031175;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cell projection morphogenesis#GO:0048858;substrate adhesion-dependent cell spreading#GO:0034446;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell morphogenesis#GO:0000902;cell development#GO:0048468;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;axonogenesis#GO:0007409;neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;extracellular structure organization#GO:0043062;generation of neurons#GO:0048699;cell adhesion#GO:0007155 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;supramolecular complex#GO:0099080;basement membrane#GO:0005604;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576;extracellular protein-containing complex#GO:0140392 extracellular matrix protein#PC00102 Integrin signalling pathway#P00034>Laminin#P00947 HUMAN|HGNC=24029|UniProtKB=P58166 P58166 INHBE PTHR11848:SF6 TGF-BETA FAMILY INHIBIN BETA E CHAIN signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;cytokine activity#GO:0005125 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;cell surface receptor signaling pathway#GO:0007166;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 growth factor#PC00112 TGF-beta signaling pathway#P00052>TGFbeta#P01286 HUMAN|HGNC=10288|UniProtKB=Q8TA86 Q8TA86 RP9 PTHR35252:SF1 RETINITIS PIGMENTOSA 9 PROTEIN RETINITIS PIGMENTOSA 9 PROTEIN HUMAN|HGNC=51234|UniProtKB=A3QJZ7 A3QJZ7 PRAMEF27 PTHR14224:SF112 SIMILAR TO PREFERENTIALLY EXPRESSED ANTIGEN IN MELANOMA-LIKE 3 PRAME FAMILY MEMBER 11-RELATED ubiquitin-like ligase-substrate adaptor activity#GO:1990756;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;enzyme-substrate adaptor activity#GO:0140767 ubiquitin-dependent protein catabolic process#GO:0006511;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;primary metabolic process#GO:0044238 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;cullin-RING ubiquitin ligase complex#GO:0031461;Cul2-RING ubiquitin ligase complex#GO:0031462;transferase complex#GO:1990234;catalytic complex#GO:1902494;ubiquitin ligase complex#GO:0000151;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535 HUMAN|HGNC=9557|UniProtKB=O00232 O00232 PSMD12 PTHR10855:SF1 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;peptidase complex#GO:1905368;proteasome complex#GO:0000502;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;proteasome regulatory particle, lid subcomplex#GO:0008541;endopeptidase complex#GO:1905369;catalytic complex#GO:1902494 protease#PC00190 Ubiquitin proteasome pathway#P00060>26S proteasome#P01489;Cell cycle#P00013>Proteasome#P00480 HUMAN|HGNC=18041|UniProtKB=Q9NSY1 Q9NSY1 BMP2K PTHR22967:SF10 SERINE/THREONINE PROTEIN KINASE BMP-2-INDUCIBLE PROTEIN KINASE protein serine/threonine kinase activity#GO:0004674;binding#GO:0005488;protein kinase activity#GO:0004672;protein-containing complex binding#GO:0044877;phosphotransferase activity, alcohol group as acceptor#GO:0016773;enzyme regulator activity#GO:0030234;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;molecular function regulator activity#GO:0098772;phosphatase regulator activity#GO:0019208;catalytic activity, acting on a protein#GO:0140096 biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of multicellular organismal process#GO:0051239;regulation of bone mineralization#GO:0030500;positive regulation of response to stimulus#GO:0048584;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of localization#GO:0032879;regulation of transport#GO:0051049;regulation of endocytosis#GO:0030100;regulation of response to stimulus#GO:0048583;regulation of developmental process#GO:0050793;regulation of cell communication#GO:0010646;positive regulation of Notch signaling pathway#GO:0045747;regulation of cellular component organization#GO:0051128;regulation of receptor-mediated endocytosis#GO:0048259;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;regulation of multicellular organismal development#GO:2000026;positive regulation of signal transduction#GO:0009967;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;regulation of Notch signaling pathway#GO:0008593 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=3078|UniProtKB=P33316 P33316 DUT PTHR11241:SF11 DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE, MITOCHONDRIAL hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;nucleoside triphosphate diphosphatase activity#GO:0047429;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;cation binding#GO:0043169;magnesium ion binding#GO:0000287;hydrolase activity#GO:0016787;metal ion binding#GO:0046872 nucleobase-containing small molecule metabolic process#GO:0055086;carbohydrate derivative biosynthetic process#GO:1901137;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing compound biosynthetic process#GO:0034654;nucleotide catabolic process#GO:0009166;metabolic process#GO:0008152;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;pyrimidine-containing compound metabolic process#GO:0072527;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;nucleobase-containing compound catabolic process#GO:0034655;organophosphate metabolic process#GO:0019637;nucleotide biosynthetic process#GO:0009165;organophosphate biosynthetic process#GO:0090407;nucleotide metabolic process#GO:0009117;organophosphate catabolic process#GO:0046434;nucleoside monophosphate biosynthetic process#GO:0009124;carbohydrate derivative catabolic process#GO:1901136;nucleoside phosphate metabolic process#GO:0006753;nucleoside monophosphate metabolic process#GO:0009123;nucleoside phosphate catabolic process#GO:1901292;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238 phosphatase#PC00181;hydrolase#PC00121 De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>dUTP pyrophosphatase#P02918 HUMAN|HGNC=18870|UniProtKB=Q7Z5Q5 Q7Z5Q5 POLN PTHR10133:SF65 DNA POLYMERASE I DNA POLYMERASE NU catalytic activity, acting on DNA#GO:0140097;DNA polymerase activity#GO:0034061;transferase activity, transferring phosphorus-containing groups#GO:0016772;nucleotidyltransferase activity#GO:0016779;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity#GO:0016740;catalytic activity#GO:0003824;DNA-directed DNA polymerase activity#GO:0003887 double-strand break repair via nonhomologous end joining#GO:0006303;macromolecule metabolic process#GO:0043170;double-strand break repair#GO:0006302;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;DNA damage response#GO:0006974;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139;primary metabolic process#GO:0044238;response to stress#GO:0006950;nucleic acid metabolic process#GO:0090304;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 DNA-directed DNA polymerase#PC00018 HUMAN|HGNC=26341|UniProtKB=Q96LM6 Q96LM6 SPMIP9 PTHR36882:SF1 TESTIS-EXPRESSED SEQUENCE 37 PROTEIN PROTEIN SPMIP9 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=32522|UniProtKB=A6NI72 A6NI72 NCF1B PTHR15706:SF6 SH3 MULTIPLE DOMAIN NEUTROPHIL CYTOSOL FACTOR 1-RELATED molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;enzyme activator activity#GO:0008047 superoxide metabolic process#GO:0006801;cellular process#GO:0009987;metabolic process#GO:0008152;reactive oxygen species metabolic process#GO:0072593 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;cytoplasm#GO:0005737;membrane protein complex#GO:0098796;oxidoreductase complex#GO:1990204;membrane#GO:0016020;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494 scaffold/adaptor protein#PC00226 HUMAN|HGNC=3433|UniProtKB=P07992 P07992 ERCC1 PTHR12749:SF0 EXCISION REPAIR CROSS-COMPLEMENTING 1 ERCC1 DNA EXCISION REPAIR PROTEIN ERCC-1 DNA binding#GO:0003677;single-stranded DNA binding#GO:0003697;damaged DNA binding#GO:0003684;binding#GO:0005488;nucleic acid binding#GO:0003676 response to stress#GO:0006950;response to radiation#GO:0009314;cellular response to light stimulus#GO:0071482;cellular process#GO:0009987;nucleotide-excision repair#GO:0006289;nucleobase-containing compound metabolic process#GO:0006139;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA damage response#GO:0006974;DNA recombination#GO:0006310;response to UV#GO:0009411;cellular response to abiotic stimulus#GO:0071214;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;response to abiotic stimulus#GO:0009628;nucleic acid metabolic process#GO:0090304;cellular response to stimulus#GO:0051716;cellular response to environmental stimulus#GO:0104004;response to light stimulus#GO:0009416;response to stimulus#GO:0050896;cellular response to radiation#GO:0071478;mitotic recombination#GO:0006312;cellular response to stress#GO:0033554 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleotide-excision repair complex#GO:0000109;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513 endodeoxyribonuclease#PC00093 HUMAN|HGNC=13910|UniProtKB=Q5HYR2 Q5HYR2 DMRTC1 PTHR12322:SF117 DOUBLESEX AND MAB-3 RELATED TRANSCRIPTION FACTOR DMRT DOUBLESEX- AND MAB-3-RELATED TRANSCRIPTION FACTOR C1 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700 regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;developmental process involved in reproduction#GO:0003006;reproductive process#GO:0022414;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;developmental process#GO:0032502;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;sex differentiation#GO:0007548;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218 HUMAN|HGNC=10581|UniProtKB=Q9UQR0 Q9UQR0 SCML2 PTHR12247:SF84 POLYCOMB GROUP PROTEIN SEX COMB ON MIDLEG-LIKE PROTEIN 2 protein binding#GO:0005515;histone binding#GO:0042393;chromatin binding#GO:0003682;binding#GO:0005488 regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=25787|UniProtKB=Q96BT3 Q96BT3 CENPT PTHR46904:SF1 CENTROMERE PROTEIN T CENTROMERE PROTEIN T mitotic cell cycle#GO:0000278;cell cycle#GO:0007049;cell cycle process#GO:0022402;cellular process#GO:0009987;chromosome segregation#GO:0007059 HUMAN|HGNC=20343|UniProtKB=Q9P0R6 Q9P0R6 GSKIP PTHR12490:SF4 GSK3B-INTERACTING PROTEIN GSK3B-INTERACTING PROTEIN protein kinase A binding#GO:0051018;binding#GO:0005488;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;protein binding#GO:0005515 biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cell communication#GO:0010646;regulation of Wnt signaling pathway#GO:0030111;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=24314|UniProtKB=Q96DZ5 Q96DZ5 CLIP3 PTHR18916:SF77 DYNACTIN 1-RELATED MICROTUBULE-BINDING CAP-GLY DOMAIN-CONTAINING LINKER PROTEIN 3 tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;microtubule binding#GO:0008017;protein binding#GO:0005515 microtubule-based process#GO:0007017;supramolecular fiber organization#GO:0097435;microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;cytoskeleton organization#GO:0007010;cytoplasmic microtubule organization#GO:0031122 microtubule end#GO:1990752;cell cortex#GO:0005938;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membrane-bounded organelle#GO:0043227;microtubule cytoskeleton#GO:0015630;nucleus#GO:0005634;cell periphery#GO:0071944;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;microtubule plus-end#GO:0035371 chaperone#PC00072 HUMAN|HGNC=28709|UniProtKB=Q9BSA9 Q9BSA9 TMEM175 PTHR31462:SF5 ENDOSOMAL/LYSOSOMAL POTASSIUM CHANNEL TMEM175 ENDOSOMAL_LYSOSOMAL PROTON CHANNEL TMEM175 potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261;metal ion transmembrane transporter activity#GO:0046873 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;vacuole#GO:0005773;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular vesicle#GO:0097708;vesicle#GO:0031982;lysosome#GO:0005764;lytic vacuole#GO:0000323;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endosome#GO:0005768 ion channel#PC00133 HUMAN|HGNC=3603|UniProtKB=P35555 P35555 FBN1 PTHR24039:SF22 FIBRILLIN-RELATED FIBRILLIN-1 extracellular matrix structural protein#PC00103 HUMAN|HGNC=26138|UniProtKB=Q6ZN57 Q6ZN57 ZFP2 PTHR23226:SF366 ZINC FINGER AND SCAN DOMAIN-CONTAINING ZINC FINGER PROTEIN ZFP2 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=28484|UniProtKB=Q86W50 Q86W50 METTL16 PTHR13393:SF0 SAM-DEPENDENT METHYLTRANSFERASE RNA N(6)-ADENOSINE-METHYLTRANSFERASE METTL16 methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;RNA methyltransferase activity#GO:0008173;catalytic activity, acting on RNA#GO:0140098;catalytic activity, acting on a nucleic acid#GO:0140640;transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;catalytic activity#GO:0003824 biosynthetic process#GO:0009058;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;mRNA processing#GO:0006397;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;post-transcriptional regulation of gene expression#GO:0010608;metabolic process#GO:0008152;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 metabolite interconversion enzyme#PC00262;methyltransferase#PC00155;transferase#PC00220 HUMAN|HGNC=20267|UniProtKB=Q92623 Q92623 TTC9 PTHR11242:SF15 ARYL HYDROCARBON RECEPTOR INTERACTING PROTEIN RELATED TETRATRICOPEPTIDE REPEAT PROTEIN 9A gene expression#GO:0010467;protein maturation#GO:0051604;protein folding#GO:0006457;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;protein modification process#GO:0036211;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;membrane#GO:0016020 chaperone#PC00072 HUMAN|HGNC=30205|UniProtKB=Q9H7C9 Q9H7C9 AAMDC PTHR15811:SF5 MTH938 DOMAIN-CONTAINING PROTEIN MTH938 DOMAIN-CONTAINING PROTEIN positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of developmental process#GO:0050793;positive regulation of cell differentiation#GO:0045597;regulation of cell differentiation#GO:0045595;positive regulation of fat cell differentiation#GO:0045600;positive regulation of developmental process#GO:0051094 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=9351|UniProtKB=Q9NQW5 Q9NQW5 PRDM7 PTHR14112:SF31 SYNOVIAL SARCOMA, X MEMBER HISTONE-LYSINE N-METHYLTRANSFERASE PRDM7 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HUMAN|HGNC=17184|UniProtKB=Q96DX5 Q96DX5 ASB9 PTHR24136:SF17 SOWAH (DROSOPHILA) HOMOLOG ANKYRIN REPEAT AND SOCS BOX PROTEIN 9 positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of protein metabolic process#GO:0051246;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;positive regulation of macromolecule metabolic process#GO:0010604;metabolic process#GO:0008152;regulation of catabolic process#GO:0009894;macromolecule metabolic process#GO:0043170;positive regulation of catabolic process#GO:0009896;protein modification by small protein conjugation#GO:0032446;regulation of biological process#GO:0050789;protein modification process#GO:0036211;primary metabolic process#GO:0044238;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of protein metabolic process#GO:0051247;protein modification by small protein conjugation or removal#GO:0070647;positive regulation of protein catabolic process#GO:0045732;regulation of protein catabolic process#GO:0042176;positive regulation of metabolic process#GO:0009893;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412 HUMAN|HGNC=18825|UniProtKB=Q86VE9 Q86VE9 SERINC5 PTHR10383:SF16 SERINE INCORPORATOR SERINE INCORPORATOR 5 cellular anatomical structure#GO:0110165;membrane#GO:0016020 protein-binding activity modulator#PC00095 HUMAN|HGNC=44121|UniProtKB=P0C264 P0C264 SBK3 PTHR24363:SF6 SERINE/THREONINE PROTEIN KINASE NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=7764|UniProtKB=Q92886 Q92886 NEUROG1 PTHR19290:SF130 BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED NEUROGENIN-1 RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;multicellular organismal process#GO:0032501;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;brain development#GO:0007420;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;axon development#GO:0061564;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;developmental process#GO:0032502;sensory organ development#GO:0007423;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;positive regulation of biosynthetic process#GO:0009891;head development#GO:0060322;nervous system development#GO:0007399;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;neuron projection development#GO:0031175;animal organ development#GO:0048513;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;neuron differentiation#GO:0030182;positive regulation of transcription by RNA polymerase II#GO:0045944;cell development#GO:0048468;forebrain development#GO:0030900;cell differentiation#GO:0030154;cell projection organization#GO:0030030;regulation of transcription by RNA polymerase II#GO:0006357;central nervous system development#GO:0007417;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;neuron development#GO:0048666;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=19710|UniProtKB=Q96JK4 Q96JK4 HHIPL1 PTHR19328:SF32 HEDGEHOG-INTERACTING PROTEIN HHIP-LIKE PROTEIN 1 protein-binding activity modulator#PC00095 HUMAN|HGNC=15173|UniProtKB=Q8NGI6 Q8NGI6 OR4D10 PTHR48002:SF68 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 4D10 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=19218|UniProtKB=Q86YW0 Q86YW0 PLCZ1 PTHR10336:SF29 PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN 1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE ZETA-1 hydrolase activity#GO:0016787;lipase activity#GO:0016298;phosphoric ester hydrolase activity#GO:0042578;phosphoric diester hydrolase activity#GO:0008081;glycerophospholipase activity#GO:0004620;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phospholipase activity#GO:0120569 single fertilization#GO:0007338;cellular process#GO:0009987;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;reproductive process#GO:0022414;fertilization#GO:0009566;positive regulation of cytosolic calcium ion concentration#GO:0007204;sexual reproduction#GO:0019953;cell activation#GO:0001775;regulation of biological quality#GO:0065008 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;nucleus#GO:0005634 hydrolase#PC00121;lipase#PC00143;metabolite interconversion enzyme#PC00262;phospholipase#PC00186 5HT2 type receptor mediated signaling pathway#P04374>PLC#P04412;Histamine H1 receptor mediated signaling pathway#P04385>PLC#P04484;Oxytocin receptor mediated signaling pathway#P04391>PLC beta#P04530;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>PLCbetagamma#P00874;Thyrotropin-releasing hormone receptor signaling pathway#P04394>PLC#P04581 HUMAN|HGNC=6279|UniProtKB=Q9NYG8 Q9NYG8 KCNK4 PTHR11003:SF30 POTASSIUM CHANNEL, SUBFAMILY K POTASSIUM CHANNEL SUBFAMILY K MEMBER 4 outward rectifier potassium channel activity#GO:0015271;potassium channel activity#GO:0005267;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;monoatomic cation channel activity#GO:0005261;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;transporter activity#GO:0005215;metal ion transmembrane transporter activity#GO:0046873;voltage-gated monoatomic cation channel activity#GO:0022843;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216 cellular process#GO:0009987;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;potassium ion transmembrane transport#GO:0071805;monoatomic ion transmembrane transport#GO:0034220;potassium ion transport#GO:0006813;transport#GO:0006810;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;establishment of localization#GO:0051234;transmembrane transport#GO:0055085 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=13539|UniProtKB=Q6RW13 Q6RW13 AGTRAP PTHR16521:SF3 TYPE-1 ANGIOTENSIN II RECEPTOR-ASSOCIATED PROTEIN TYPE-1 ANGIOTENSIN II RECEPTOR-ASSOCIATED PROTEIN regulation of blood pressure#GO:0008217;circulatory system process#GO:0003013;blood circulation#GO:0008015;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;system process#GO:0003008;regulation of biological quality#GO:0065008 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HUMAN|HGNC=12513|UniProtKB=P09936 P09936 UCHL1 PTHR10589:SF19 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L1 deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;cysteine-type peptidase activity#GO:0008234;cysteine-type deubiquitinase activity#GO:0004843;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;protein catabolic process#GO:0030163;catabolic process#GO:0009056;primary metabolic process#GO:0044238;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 protease#PC00190;protein modifying enzyme#PC00260;cysteine protease#PC00081 Parkinson disease#P00049>UCH-L1#P01210 HUMAN|HGNC=20731|UniProtKB=Q9HAV0 Q9HAV0 GNB4 PTHR19850:SF28 GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-4 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;signaling receptor complex adaptor activity#GO:0030159;signaling adaptor activity#GO:0035591 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;cytoplasmic side of plasma membrane#GO:0009898;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494;extrinsic component of cytoplasmic side of plasma membrane#GO:0031234;intracellular anatomical structure#GO:0005622;side of membrane#GO:0098552;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;cytoplasmic side of membrane#GO:0098562;extrinsic component of membrane#GO:0019898;extrinsic component of plasma membrane#GO:0019897 heterotrimeric G-protein#PC00117;G-protein#PC00020;protein-binding activity modulator#PC00095 Thyrotropin-releasing hormone receptor signaling pathway#P04394>G-Protein#P04584;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Gbeta#P00710;5HT2 type receptor mediated signaling pathway#P04374>G-protein#P04416;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Gbeta#P00753;Enkephalin release#P05913>G-Protein (i)#P05974;Enkephalin release#P05913>G-Protein (s)#P05977;GABA-B receptor II signaling#P05731>Gbeta#P05755;Gonadotropin-releasing hormone receptor pathway#P06664>Gbeta#P06769;Metabotropic glutamate receptor group III pathway#P00039>G-Protein#P01045;5HT4 type receptor mediated signaling pathway#P04376>G-protein#P04430;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>G-Protein#P01073;Opioid proopiomelanocortin pathway#P05917>G-protein#P06012;Angiotensin II-stimulated signaling through G proteins and beta-arrestin#P05911>Gbeta#P05930;Oxytocin receptor mediated signaling pathway#P04391>G-Protein#P04534;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Gbeta#P00727;Cortocotropin releasing factor receptor signaling pathway#P04380>G-Protein#P04458;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>G-Protein#P01085;Beta3 adrenergic receptor signaling pathway#P04379>G-Protein#P04448;Beta1 adrenergic receptor signaling pathway#P04377>G-Protein#P04436;Opioid prodynorphin pathway#P05916>G-protein#P06002;Wnt signaling pathway#P00057>GBeta#P01457;Metabotropic glutamate receptor group II pathway#P00040>G-protein#P01047;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GIRK#P00743;Histamine H2 receptor mediated signaling pathway#P04386>G-Protein#P04490;Beta2 adrenergic receptor signaling pathway#P04378>G-Protein#P04443;Dopamine receptor mediated signaling pathway#P05912>Gbeta#P05954;Opioid proenkephalin pathway#P05915>G-protein#P05994;Histamine H1 receptor mediated signaling pathway#P04385>G-Protein#P04488;PI3 kinase pathway#P00048>Gbetagamma#P01188;5HT1 type receptor mediated signaling pathway#P04373>G-protein#P04408;Endogenous cannabinoid signaling#P05730>Gbeta#P05745 HUMAN|HGNC=21270|UniProtKB=Q9BQ67 Q9BQ67 GRWD1 PTHR45903:SF1 GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1 GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1 cellular process#GO:0009987;cellular component biogenesis#GO:0044085;ribosome biogenesis#GO:0042254;ribonucleoprotein complex biogenesis#GO:0022613;cellular component organization or biogenesis#GO:0071840 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=26748|UniProtKB=Q8N9E0 Q8N9E0 FAM133A PTHR31911:SF4 PROTEIN FAM133 PROTEIN FAM133A RNA metabolism protein#PC00031 HUMAN|HGNC=9318|UniProtKB=Q96LZ3 Q96LZ3 PPP3R2 PTHR45942:SF2 Calcineurin subunit B CALCINEURIN SUBUNIT B TYPE 2 molecular function regulator activity#GO:0098772;phosphatase regulator activity#GO:0019208;enzyme binding#GO:0019899;binding#GO:0005488;phosphatase binding#GO:0019902;protein phosphatase regulator activity#GO:0019888;enzyme regulator activity#GO:0030234;protein binding#GO:0005515 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;signaling#GO:0023052;calcineurin-mediated signaling#GO:0097720;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cell communication#GO:0007154;calcium-mediated signaling#GO:0019722;intracellular signal transduction#GO:0035556 protein serine/threonine phosphatase complex#GO:0008287;catalytic complex#GO:1902494;intracellular protein-containing complex#GO:0140535;protein-containing complex#GO:0032991 Wnt signaling pathway#P00057>Calcineurin#P01446 HUMAN|HGNC=8528|UniProtKB=P01178 P01178 OXT PTHR11681:SF2 NEUROPHYSIN OXYTOCIN-NEUROPHYSIN 1 PROPROTEIN signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;neuropeptide hormone activity#GO:0005184;G protein-coupled receptor binding#GO:0001664;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;molecular function activator activity#GO:0140677;hormone activity#GO:0005179;protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488 regulation of muscle system process#GO:0090257;regulation of biological process#GO:0050789;positive regulation of multicellular organismal process#GO:0051240;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of muscle contraction#GO:0006937;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;regulation of multicellular organismal process#GO:0051239;regulation of system process#GO:0044057;regulation of smooth muscle contraction#GO:0006940 secretory vesicle#GO:0099503;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;extracellular region#GO:0005576;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;secretory granule#GO:0030141 peptide hormone#PC00179;neuropeptide#PC00162 Vasopressin synthesis#P04395>Pro-Neurophysin#P04591;Opioid prodynorphin pathway#P05916>provasopressin#P05999;Vasopressin synthesis#P04395>Vasopressin#P04590;Opioid prodynorphin pathway#P05916>prepropressophysin#G06048;Opioid prodynorphin pathway#P05916>prepropressophysin#G06050;Vasopressin synthesis#P04395>Glycopeptide#P04593;Vasopressin synthesis#P04395>Signal Peptide#P04597;Vasopressin synthesis#P04395>Pro-Vasopressin#P04598;Vasopressin synthesis#P04395>Pro2-Vasopressin#P04595;Vasopressin synthesis#P04395>Neurophysin#P04594;Opioid prodynorphin pathway#P05916>vasopressin#P06000 HUMAN|HGNC=6325|UniProtKB=O60282 O60282 KIF5C PTHR24115:SF380 KINESIN-RELATED KINESIN HEAVY CHAIN ISOFORM 5C isomerase activity#GO:0016853;ribonucleoside triphosphate phosphatase activity#GO:0017111;tubulin binding#GO:0015631;macromolecular conformation isomerase activity#GO:0120543;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;ATP hydrolysis activity#GO:0016887;microtubule motor activity#GO:0003777;hydrolase activity#GO:0016787;microtubule binding#GO:0008017;polypeptide conformation or assembly isomerase activity#GO:0120544;cytoskeletal motor activity#GO:0003774;hydrolase activity, acting on acid anhydrides#GO:0016817;cytoskeletal protein binding#GO:0008092;protein binding#GO:0005515;plus-end-directed microtubule motor activity#GO:0008574;ATP-dependent activity#GO:0140657;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488 cellular localization#GO:0051641;axonogenesis#GO:0007409;neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;microtubule-based transport#GO:0099111;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell morphogenesis#GO:0000902;establishment of organelle localization#GO:0051656;cell development#GO:0048468;motor neuron axon guidance#GO:0008045;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cell projection morphogenesis#GO:0048858;microtubule-based process#GO:0007017;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;synaptic vesicle localization#GO:0097479;establishment of vesicle localization#GO:0051650;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;organelle transport along microtubule#GO:0072384;neuron projection development#GO:0031175;synaptic vesicle transport#GO:0048489;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;localization#GO:0051179;anatomical structure development#GO:0048856;system development#GO:0048731;anterograde axonal transport#GO:0008089;axonal transport#GO:0098930;organelle localization#GO:0051640;microtubule-based movement#GO:0007018;establishment of localization#GO:0051234;cellular developmental process#GO:0048869;transport along microtubule#GO:0010970;neuron projection guidance#GO:0097485;vesicle cytoskeletal trafficking#GO:0099518;neurogenesis#GO:0022008;mitochondrion localization#GO:0051646;intracellular transport#GO:0046907;vesicle transport along microtubule#GO:0047496;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;transport#GO:0006810;cytoskeleton-dependent intracellular transport#GO:0030705;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;axon development#GO:0061564;axon guidance#GO:0007411;axo-dendritic transport#GO:0008088;vesicle localization#GO:0051648 organelle#GO:0043226;cellular anatomical structure#GO:0110165;microtubule#GO:0005874;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;supramolecular complex#GO:0099080;microtubule associated complex#GO:0005875;supramolecular polymer#GO:0099081;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cytoskeleton#GO:0005856 microtubule or microtubule-binding cytoskeletal protein#PC00157;microtubule binding motor protein#PC00156 HUMAN|HGNC=30801|UniProtKB=Q9UKB5 Q9UKB5 AJAP1 PTHR32422:SF0 ADHERENS JUNCTION-ASSOCIATED PROTEIN 1 ADHERENS JUNCTION-ASSOCIATED PROTEIN 1 binding#GO:0005488;protein binding#GO:0005515;beta-catenin binding#GO:0008013 cytoplasmic side of membrane#GO:0098562;anchoring junction#GO:0070161;cell-cell contact zone#GO:0044291;adherens junction#GO:0005912;side of membrane#GO:0098552;cell junction#GO:0030054;cell periphery#GO:0071944;cytoplasmic side of plasma membrane#GO:0009898;membrane#GO:0016020;cell-cell junction#GO:0005911;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 HUMAN|HGNC=29523|UniProtKB=Q9Y6A4 Q9Y6A4 CFAP20 PTHR12458:SF11 ORF PROTEIN CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 20 microtubule cytoskeleton organization#GO:0000226;anatomical structure development#GO:0048856;multicellular organismal reproductive process#GO:0048609;axoneme assembly#GO:0035082;organelle assembly#GO:0070925;microtubule bundle formation#GO:0001578;spermatid development#GO:0007286;sexual reproduction#GO:0019953;microtubule-based movement#GO:0007018;cell motility#GO:0048870;reproductive process#GO:0022414;developmental process involved in reproduction#GO:0003006;germ cell development#GO:0007281;cellular developmental process#GO:0048869;sperm axoneme assembly#GO:0007288;flagellated sperm motility#GO:0030317;plasma membrane bounded cell projection assembly#GO:0120031;spermatogenesis#GO:0007283;developmental process#GO:0032502;multicellular organismal process#GO:0032501;male gamete generation#GO:0048232;plasma membrane bounded cell projection organization#GO:0120036;cilium-dependent cell motility#GO:0060285;sperm flagellum assembly#GO:0120316;cilium organization#GO:0044782;spermatid differentiation#GO:0048515;cilium or flagellum-dependent cell motility#GO:0001539;cilium movement#GO:0003341;gamete generation#GO:0007276;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cellular process involved in reproduction in multicellular organism#GO:0022412;cell development#GO:0048468;cellular component organization#GO:0016043;cilium assembly#GO:0060271;sperm motility#GO:0097722;anatomical structure morphogenesis#GO:0009653;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;motile cilium assembly#GO:0044458;anatomical structure formation involved in morphogenesis#GO:0048646;microtubule-based process#GO:0007017;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;cilium movement involved in cell motility#GO:0060294;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cell projection assembly#GO:0030031 cytoplasmic microtubule#GO:0005881;motile cilium#GO:0031514;organelle#GO:0043226;cellular anatomical structure#GO:0110165;axonemal microtubule#GO:0005879;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;9+2 motile cilium#GO:0097729;cilium#GO:0005929;intracellular organelle#GO:0043229;microtubule#GO:0005874;axoneme#GO:0005930;supramolecular fiber#GO:0099512;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;microtubule cytoskeleton#GO:0015630;supramolecular complex#GO:0099080;sperm flagellum#GO:0036126;supramolecular polymer#GO:0099081;ciliary plasm#GO:0097014;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule organizing center#GO:0005815;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513 Transcription regulation by bZIP transcription factor#P00055>TFIIB#P01397;General transcription regulation#P00023>TFIIB#P00668 HUMAN|HGNC=6001|UniProtKB=P60568 P60568 IL2 PTHR48487:SF1 INTERLEUKIN-2 INTERLEUKIN-2 molecular function activator activity#GO:0140677;protein binding#GO:0005515;binding#GO:0005488;cytokine receptor binding#GO:0005126;signaling receptor binding#GO:0005102;cytokine activity#GO:0005125;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;growth factor receptor binding#GO:0070851 biological regulation#GO:0065007;response to chemical#GO:0042221;response to cytokine#GO:0034097;signal transduction#GO:0007165;cellular process#GO:0009987;cell surface receptor signaling pathway#GO:0007166;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;interleukin-2-mediated signaling pathway#GO:0038110;cellular response to stimulus#GO:0051716;response to peptide#GO:1901652;cell communication#GO:0007154;cytokine-mediated signaling pathway#GO:0019221 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 Interleukin signaling pathway#P00036>Interleukin#P00970;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>IL2#P00870 HUMAN|HGNC=6758|UniProtKB=Q9Y586 Q9Y586 MAB21L2 PTHR10656:SF37 CELL FATE DETERMINING PROTEIN MAB21-RELATED PROTEIN MAB-21-LIKE 2 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 transferase#PC00220;nucleotidyltransferase#PC00174 HUMAN|HGNC=25770|UniProtKB=Q9H977 Q9H977 WDR54 PTHR13720:SF40 WD-40 REPEAT PROTEIN WD REPEAT-CONTAINING PROTEIN 54 plasma membrane bounded cell projection#GO:0120025;membrane-bounded organelle#GO:0043227;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;motile cilium#GO:0031514;cilium#GO:0005929 microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=20711|UniProtKB=Q96IU2 Q96IU2 ZBED3 PTHR35827:SF2 ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 3 ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 3 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=7783|UniProtKB=Q9Y4A8 Q9Y4A8 NFE2L3 PTHR24411:SF8 NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR 3 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 basic leucine zipper transcription factor#PC00056 HUMAN|HGNC=5798|UniProtKB=A0A0A0MRZ7 A0A0A0MRZ7 IGKV2D-26 PTHR23267:SF529 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN KAPPA VARIABLE 2D-26 immune system process#GO:0002376;immune response#GO:0006955;response to stimulus#GO:0050896 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=18990|UniProtKB=Q5T601 Q5T601 ADGRF1 PTHR45813:SF3 IG-LIKE DOMAIN-CONTAINING PROTEIN ADHESION G PROTEIN-COUPLED RECEPTOR F1 molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 synapse organization#GO:0050808;system development#GO:0048731;anatomical structure development#GO:0048856;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cell junction organization#GO:0034330;regulation of cellular process#GO:0050794;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;developmental process#GO:0032502;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;G protein-coupled receptor signaling pathway#GO:0007186;neuron development#GO:0048666;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;cell junction assembly#GO:0034329;cell development#GO:0048468;signaling#GO:0023052;synapse assembly#GO:0007416;response to stimulus#GO:0050896;cell differentiation#GO:0030154;cell projection organization#GO:0030030;neuron differentiation#GO:0030182;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;signal transduction#GO:0007165;cellular component biogenesis#GO:0044085;neuron projection development#GO:0031175;nervous system development#GO:0007399;cellular component assembly#GO:0022607 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021 HUMAN|HGNC=13399|UniProtKB=O60422 O60422 ONECUT3 PTHR14057:SF34 TRANSCRIPTION FACTOR ONECUT ONE CUT DOMAIN FAMILY MEMBER 3 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 homeodomain transcription factor#PC00119;DNA-binding transcription factor#PC00218 HUMAN|HGNC=4668|UniProtKB=Q9Y5Q8 Q9Y5Q8 GTF3C5 PTHR13230:SF5 GENERAL TRANSCRIPTION FACTOR IIIC, POLYPEPTIDE 5 GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 5 rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;rRNA transcription#GO:0009303;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;transcription by RNA polymerase III#GO:0006383;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;DNA-templated transcription#GO:0006351;RNA biosynthetic process#GO:0032774;DNA-templated transcription initiation#GO:0006352;transcription initiation at RNA polymerase III promoter#GO:0006384 transcription regulator complex#GO:0005667;transcription factor TFIIIC complex#GO:0000127;protein-containing complex#GO:0032991 general transcription factor#PC00259 HUMAN|HGNC=53645|UniProtKB=A0A1B0GW64 A0A1B0GW64 SMIM33 PTHR37873:SF1 SMALL INTEGRAL MEMBRANE PROTEIN 33 SMALL INTEGRAL MEMBRANE PROTEIN 33 HUMAN|HGNC=43621|UniProtKB=A0A1W2PQD8 A0A1W2PQD8 SSU72L2 PTHR20383:SF10 RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE SSU72 LIKE PROTEIN 1-RELATED catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721;hydrolase activity#GO:0016787 RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;DNA-templated transcription termination#GO:0006353;mRNA processing#GO:0006397;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123;transcription by RNA polymerase II#GO:0006366;nucleobase-containing compound biosynthetic process#GO:0034654;termination of RNA polymerase II transcription#GO:0006369;metabolic process#GO:0008152;mRNA 3'-end processing#GO:0031124;DNA-templated transcription#GO:0006351;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187 mRNA cleavage and polyadenylation specificity factor complex#GO:0005847;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mRNA cleavage factor complex#GO:0005849;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231 protein phosphatase#PC00195 HUMAN|HGNC=30703|UniProtKB=Q8NEL0 Q8NEL0 CCDC54 PTHR37880:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 54 COILED-COIL DOMAIN-CONTAINING PROTEIN 54 HUMAN|HGNC=9289|UniProtKB=Q96PQ5 Q96PQ5 PPP1R2P1 PTHR12398:SF35 PROTEIN PHOSPHATASE INHIBITOR PROTEIN PHOSPHATASE INHIBITOR 2-RELATED protein phosphatase inhibitor activity#GO:0004864;enzyme inhibitor activity#GO:0004857;phosphatase regulator activity#GO:0019208;phosphatase inhibitor activity#GO:0019212;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;protein phosphatase regulator activity#GO:0019888;molecular function inhibitor activity#GO:0140678 signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 phosphatase inhibitor#PC00183 HUMAN|HGNC=27025|UniProtKB=Q8N1A6 Q8N1A6 C4orf33 PTHR31475:SF3 UPF0462 PROTEIN UPF0462 PROTEIN C4ORF33 HUMAN|HGNC=25237|UniProtKB=Q9H1E5 Q9H1E5 TMX4 PTHR46107:SF1 DUMPY: SHORTER THAN WILD-TYPE THIOREDOXIN-RELATED TRANSMEMBRANE PROTEIN 4 oxidoreductase activity#GO:0016491;disulfide oxidoreductase activity#GO:0015036;catalytic activity#GO:0003824;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 HUMAN|HGNC=452|UniProtKB=Q9NP70 Q9NP70 AMBN PTHR14115:SF0 AMELOBLASTIN AMELOBLASTIN signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;growth factor activity#GO:0008083 cell adhesion#GO:0007155;cellular process#GO:0009987 HUMAN|HGNC=26868|UniProtKB=Q8N7R7 Q8N7R7 CCNYL1 PTHR14248:SF32 CYCLIN Y, ISOFORM A CYCLIN-Y-LIKE PROTEIN 1 kinase activator activity#GO:0019209;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677;protein serine/threonine kinase activator activity#GO:0043539;cyclin-dependent protein serine/threonine kinase regulator activity#GO:0016538;enzyme activator activity#GO:0008047;protein kinase activator activity#GO:0030295;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207;cyclin-dependent protein kinase regulator activity#GO:0019914;protein kinase regulator activity#GO:0019887 regulation of biological process#GO:0050789;regulation of canonical Wnt signaling pathway#GO:0060828;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of Wnt signaling pathway#GO:0030111;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of response to stimulus#GO:0048583;regulation of signaling#GO:0023051 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HUMAN|HGNC=14893|UniProtKB=Q9BZM6 Q9BZM6 ULBP1 PTHR16675:SF268 MHC CLASS I-RELATED UL16-BINDING PROTEIN 1 signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;molecular function activator activity#GO:0140677;protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488 positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;positive regulation of immune effector process#GO:0002699;response to other organism#GO:0051707;positive regulation of cellular process#GO:0048522;immune response#GO:0006955;innate immune response#GO:0045087;response to external stimulus#GO:0009605;defense response#GO:0006952;positive regulation of leukocyte mediated immunity#GO:0002705;cell killing#GO:0001906;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;response to external biotic stimulus#GO:0043207;regulation of leukocyte mediated immunity#GO:0002703;positive regulation of lymphocyte mediated immunity#GO:0002708;antigen processing and presentation#GO:0019882;regulation of immune effector process#GO:0002697;regulation of leukocyte mediated cytotoxicity#GO:0001910;regulation of immune response#GO:0050776;defense response to other organism#GO:0098542;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;positive regulation of immune system process#GO:0002684;positive regulation of biological process#GO:0048518;defense response to symbiont#GO:0140546;cellular process#GO:0009987;natural killer cell mediated cytotoxicity#GO:0042267;immune effector process#GO:0002252;response to stimulus#GO:0050896;positive regulation of adaptive immune response#GO:0002821;biological process involved in interspecies interaction between organisms#GO:0044419;leukocyte mediated cytotoxicity#GO:0001909;regulation of biological process#GO:0050789;natural killer cell mediated immunity#GO:0002228;lymphocyte mediated immunity#GO:0002449;leukocyte mediated immunity#GO:0002443;regulation of lymphocyte mediated immunity#GO:0002706;immune system process#GO:0002376;regulation of cell killing#GO:0031341 external side of plasma membrane#GO:0009897;extracellular region#GO:0005576;side of membrane#GO:0098552;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cell surface#GO:0009986;cellular anatomical structure#GO:0110165 major histocompatibility complex protein#PC00149;defense/immunity protein#PC00090 HUMAN|HGNC=27000|UniProtKB=Q8IVT2 Q8IVT2 MISP PTHR18839:SF3 MITOTIC INTERACTOR AND SUBSTRATE OF PLK1 MISP FAMILY MEMBER MITOTIC INTERACTOR AND SUBSTRATE OF PLK1 HUMAN|HGNC=10577|UniProtKB=Q93045 Q93045 STMN2 PTHR10104:SF18 STATHMIN STATHMIN-2 protein binding#GO:0005515;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631 regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;cell development#GO:0048468;cell differentiation#GO:0030154;cell projection organization#GO:0030030;regulation of cellular component organization#GO:0051128;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;neuron development#GO:0048666;cellular component disassembly#GO:0022411;cellular process#GO:0009987;organelle organization#GO:0006996;neuron projection development#GO:0031175;regulation of microtubule cytoskeleton organization#GO:0070507;nervous system development#GO:0007399;cytoskeleton organization#GO:0007010;microtubule depolymerization#GO:0007019;neuron differentiation#GO:0030182;protein-containing complex organization#GO:0043933;microtubule-based process#GO:0007017;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;protein-containing complex disassembly#GO:0032984;regulation of cellular process#GO:0050794;regulation of cytoskeleton organization#GO:0051493;regulation of microtubule-based process#GO:0032886;system development#GO:0048731;supramolecular fiber organization#GO:0097435;microtubule cytoskeleton organization#GO:0000226;anatomical structure development#GO:0048856;microtubule polymerization or depolymerization#GO:0031109;protein depolymerization#GO:0051261;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;developmental process#GO:0032502;regulation of microtubule polymerization or depolymerization#GO:0031110;neurogenesis#GO:0022008;cellular developmental process#GO:0048869 cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;distal axon#GO:0150034;cytoplasm#GO:0005737;neuron projection#GO:0043005;site of polarized growth#GO:0030427;intracellular anatomical structure#GO:0005622;axon#GO:0030424;growth cone#GO:0030426 non-motor microtubule binding protein#PC00166;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=29923|UniProtKB=Q9H1E3 Q9H1E3 NUCKS1 PTHR15361:SF1 RAD51/NUKS-INTERACTING PROTEIN NUCLEAR UBIQUITOUS CASEIN AND CYCLIN-DEPENDENT KINASE SUBSTRATE 1 DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;binding#GO:0005488;single-stranded DNA binding#GO:0003697 double-strand break repair#GO:0006302;macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;DNA recombination#GO:0006310;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;interstrand cross-link repair#GO:0036297;nucleobase-containing compound metabolic process#GO:0006139;cellular process#GO:0009987;response to stress#GO:0006950;cellular response to stress#GO:0033554;recombinational repair#GO:0000725;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;double-strand break repair via homologous recombination#GO:0000724;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=9257|UniProtKB=Q08752 Q08752 PPID PTHR11071:SF594 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 chaperone#PC00072 HUMAN|HGNC=16735|UniProtKB=A5PLL7 A5PLL7 PEDS1 PTHR48177:SF2 TRANSMEMBRANE PROTEIN 189 PLASMANYLETHANOLAMINE DESATURASE 1 oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824 biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;cellular process#GO:0009987;lipid metabolic process#GO:0006629;primary metabolic process#GO:0044238;metabolic process#GO:0008152 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum membrane#GO:0005789 HUMAN|HGNC=4076|UniProtKB=P47869 P47869 GABRA2 PTHR18945:SF218 NEUROTRANSMITTER GATED ION CHANNEL GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-2 channel activity#GO:0015267;molecular transducer activity#GO:0060089;gated channel activity#GO:0022836;transmembrane signaling receptor activity#GO:0004888;ligand-gated monoatomic ion channel activity#GO:0015276;signaling receptor activity#GO:0038023;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion channel activity#GO:0005216;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;neurotransmitter receptor activity#GO:0030594 animal gross anatomical part developmental process#GO:0160108;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698;transmembrane transport#GO:0055085;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;cell junction assembly#GO:0034329;signaling#GO:0023052;synapse assembly#GO:0007416;chloride transport#GO:0006821;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;synaptic signaling#GO:0099536;cellular component biogenesis#GO:0044085;nervous system development#GO:0007399;monoatomic anion transmembrane transport#GO:0098656;cellular component assembly#GO:0022607;synapse organization#GO:0050808;trans-synaptic signaling#GO:0099537;system development#GO:0048731;anatomical structure development#GO:0048856;localization#GO:0051179;cell communication#GO:0007154;chloride transmembrane transport#GO:1902476;chemical synaptic transmission#GO:0007268;monoatomic anion transport#GO:0006820;cell junction organization#GO:0034330;anterograde trans-synaptic signaling#GO:0098916;transport#GO:0006810;developmental process#GO:0032502;establishment of localization#GO:0051234;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;multicellular organismal process#GO:0032501 neuron projection#GO:0043005;cell periphery#GO:0071944;cell leading edge#GO:0031252;membrane#GO:0016020;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;plasma membrane region#GO:0098590;protein-containing complex#GO:0032991;neuron projection membrane#GO:0032589;signaling receptor complex#GO:0043235;cell junction#GO:0030054;postsynapse#GO:0098794;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;synapse#GO:0045202;cellular anatomical structure#GO:0110165;leading edge membrane#GO:0031256;dendritic tree#GO:0097447;dendrite#GO:0030425;cell projection membrane#GO:0031253 ligand-gated ion channel#PC00141 HUMAN|HGNC=18882|UniProtKB=P59544 P59544 TAS2R50 PTHR11394:SF43 TASTE RECEPTOR TYPE 2 TASTE RECEPTOR TYPE 2 MEMBER 50 transmembrane signaling receptor activity#GO:0004888;taste receptor activity#GO:0008527;signaling receptor activity#GO:0038023;bitter taste receptor activity#GO:0033038;molecular transducer activity#GO:0060089 multicellular organismal process#GO:0032501;response to stimulus#GO:0050896;response to chemical#GO:0042221;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;detection of chemical stimulus#GO:0009593;sensory perception of bitter taste#GO:0050913;detection of chemical stimulus involved in sensory perception of bitter taste#GO:0001580;system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of taste#GO:0050909;detection of chemical stimulus involved in sensory perception of taste#GO:0050912;nervous system process#GO:0050877;sensory perception#GO:0007600 membrane#GO:0016020;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=29200|UniProtKB=Q9ULR5 Q9ULR5 PAIP2B PTHR13154:SF5 POLYADENYLATE-BINDING PROTEIN-INTERACTING PROTEIN 2 POLYADENYLATE-BINDING PROTEIN-INTERACTING PROTEIN 2B translation regulator activity#GO:0045182 negative regulation of translation#GO:0017148;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=12660|UniProtKB=Q5SQQ9 Q5SQQ9 VAX1 PTHR24339:SF32 HOMEOBOX PROTEIN EMX-RELATED VENTRAL ANTERIOR HOMEOBOX 1 DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 developmental process#GO:0032502;neuron differentiation#GO:0030182;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;multicellular organism development#GO:0007275;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;animal organ development#GO:0048513;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;head development#GO:0060322;nervous system development#GO:0007399;regulation of nucleobase-containing compound metabolic process#GO:0019219;brain development#GO:0007420;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;anatomical structure development#GO:0048856;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;central nervous system development#GO:0007417;regulation of cellular process#GO:0050794 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 homeodomain transcription factor#PC00119 HUMAN|HGNC=18402|UniProtKB=Q04323 Q04323 UBXN1 PTHR46340:SF1 UBX DOMAIN-CONTAINING PROTEIN 1 UBX DOMAIN-CONTAINING PROTEIN 1 protein binding#GO:0005515;polyubiquitin modification-dependent protein binding#GO:0031593;modification-dependent protein binding#GO:0140030;binding#GO:0005488 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of protein metabolic process#GO:0051246;negative regulation of macromolecule metabolic process#GO:0010605;regulation of proteasomal protein catabolic process#GO:0061136;negative regulation of protein catabolic process#GO:0042177;biological regulation#GO:0065007;regulation of ubiquitin-dependent protein catabolic process#GO:2000058;negative regulation of cellular process#GO:0048523;regulation of protein ubiquitination#GO:0031396;regulation of protein modification process#GO:0031399;negative regulation of ubiquitin-dependent protein catabolic process#GO:2000059;regulation of catabolic process#GO:0009894;negative regulation of biological process#GO:0048519;regulation of protein modification by small protein conjugation or removal#GO:1903320;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032435;negative regulation of proteasomal protein catabolic process#GO:1901799;negative regulation of metabolic process#GO:0009892;negative regulation of protein metabolic process#GO:0051248;negative regulation of protein ubiquitination#GO:0031397;regulation of post-translational protein modification#GO:1901873;regulation of proteasomal ubiquitin-dependent protein catabolic process#GO:0032434;negative regulation of catabolic process#GO:0009895;regulation of protein catabolic process#GO:0042176 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=33107|UniProtKB=Q6AW86 Q6AW86 ZNF324B PTHR24377:SF621 IP01015P-RELATED ZINC FINGER PROTEIN 324A-RELATED double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=1280|UniProtKB=P56557 P56557 TMEM50B PTHR13180:SF0 SMALL MEMBRANE PROTEIN-RELATED TRANSMEMBRANE PROTEIN 50B cytosolic transport#GO:0016482;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;retrograde transport, endosome to Golgi#GO:0042147;endosomal transport#GO:0016197;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;transport#GO:0006810;intracellular transport#GO:0046907 intracellular organelle#GO:0043229;endosome membrane#GO:0010008;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane protein complex#GO:0098796;intracellular vesicle#GO:0097708;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;vesicle membrane#GO:0012506;membrane#GO:0016020;cytoplasmic vesicle membrane#GO:0030659;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasm#GO:0005737 HUMAN|HGNC=20779|UniProtKB=Q9H3R1 Q9H3R1 NDST4 PTHR10605:SF45 HEPARAN SULFATE SULFOTRANSFERASE N-HEPARAN SULFATE SULFOTRANSFERASE 4 deacetylase activity#GO:0019213;transferase activity, transferring sulphur-containing groups#GO:0016782;sulfotransferase activity#GO:0008146;catalytic activity#GO:0003824;transferase activity#GO:0016740;deacylase activity#GO:0160215 biosynthetic process#GO:0009058;proteoglycan biosynthetic process#GO:0030166;carbohydrate derivative metabolic process#GO:1901135;protein O-linked glycosylation#GO:0006493;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;proteoglycan metabolic process#GO:0006029;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226 metabolite interconversion enzyme#PC00262;transferase#PC00220 HUMAN|HGNC=17675|UniProtKB=Q9HAV4 Q9HAV4 XPO5 PTHR11223:SF3 EXPORTIN 1/5 EXPORTIN-5 nucleocytoplasmic carrier activity#GO:0140142;molecular carrier activity#GO:0140104;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 nucleobase-containing compound transport#GO:0015931;RNA transport#GO:0050658;RNA localization#GO:0006403;establishment of RNA localization#GO:0051236;nucleocytoplasmic transport#GO:0006913;localization#GO:0051179;nucleic acid transport#GO:0050657;cellular localization#GO:0051641;nuclear transport#GO:0051169;nuclear export#GO:0051168;macromolecule localization#GO:0033036;nitrogen compound transport#GO:0071705;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907;transport#GO:0006810;establishment of localization#GO:0051234 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 transporter#PC00227 HUMAN|HGNC=18055|UniProtKB=Q86YW7 Q86YW7 GPHB5 PTHR11515:SF14 GLYCOPROTEIN HORMONE BETA CHAIN GLYCOPROTEIN HORMONE BETA-5 molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;hormone activity#GO:0005179;molecular function activator activity#GO:0140677;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 peptide hormone#PC00179 HUMAN|HGNC=8284|UniProtKB=P47888 P47888 OR3A3 PTHR48001:SF147 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 3A3 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cell communication#GO:0007154 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=1876|UniProtKB=O15519 O15519 CFLAR PTHR10454:SF239 CASPASE CASP8 AND FADD-LIKE APOPTOSIS REGULATOR peptidase regulator activity#GO:0061134;endopeptidase regulator activity#GO:0061135;hydrolase activity#GO:0016787;enzyme inhibitor activity#GO:0004857;peptidase activator activity#GO:0016504;catalytic activity#GO:0003824;cysteine-type endopeptidase activity#GO:0004197;molecular function regulator activity#GO:0098772;catalytic activity, acting on a protein#GO:0140096;endopeptidase inhibitor activity#GO:0004866;peptidase inhibitor activity#GO:0030414;cysteine-type endopeptidase inhibitor activity#GO:0004869;molecular function activator activity#GO:0140677;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;cysteine-type peptidase activity#GO:0008234;enzyme activator activity#GO:0008047;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233 mononuclear cell differentiation#GO:1903131;apoptotic process#GO:0006915;regulation of biological process#GO:0050789;leukocyte differentiation#GO:0002521;regulation of programmed cell death#GO:0043067;cell development#GO:0048468;signaling#GO:0023052;positive regulation of programmed cell death#GO:0043068;myeloid cell differentiation#GO:0030099;extrinsic apoptotic signaling pathway#GO:0097191;cell differentiation#GO:0030154;response to stimulus#GO:0050896;cell surface receptor signaling pathway#GO:0007166;regulation of apoptotic process#GO:0042981;extrinsic apoptotic signaling pathway via death domain receptors#GO:0008625;positive regulation of apoptotic process#GO:0043065;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;regulation of neuron apoptotic process#GO:0043523;anatomical structure development#GO:0048856;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cell death#GO:0008219;programmed cell death#GO:0012501;regulation of cellular process#GO:0050794;developmental process#GO:0032502;positive regulation of neuron apoptotic process#GO:0043525;cellular developmental process#GO:0048869;apoptotic signaling pathway#GO:0097190;positive regulation of cellular process#GO:0048522;hemopoiesis#GO:0030097;biological regulation#GO:0065007 intracellular anatomical structure#GO:0005622;endopeptidase complex#GO:1905369;catalytic complex#GO:1902494;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;peptidase complex#GO:1905368;plasma membrane#GO:0005886;cytoplasm#GO:0005737;caspase complex#GO:0008303;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944 protease#PC00190;protein modifying enzyme#PC00260 FAS signaling pathway#P00020>Pro-Caspase8#P00604;FAS signaling pathway#P00020>Caspase8#P00594;Apoptosis signaling pathway#P00006>Flip#P00284 HUMAN|HGNC=29652|UniProtKB=Q9BQA1 Q9BQA1 WDR77 PTHR46853:SF3 METHYLOSOME PROTEIN 50 METHYLOSOME PROTEIN WDR77 organelle#GO:0043226;methyltransferase complex#GO:0034708;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;transferase complex#GO:1990234;catalytic complex#GO:1902494;intracellular organelle#GO:0043229 HUMAN|HGNC=26161|UniProtKB=P57737 P57737 CORO7 PTHR10856:SF20 CORONIN CORONIN-7 binding#GO:0005488;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;actin filament binding#GO:0051015;protein binding#GO:0005515;protein-containing complex binding#GO:0044877 cellular component organization or biogenesis#GO:0071840;actin filament organization#GO:0007015;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;cell migration#GO:0016477;positive regulation of response to stimulus#GO:0048584;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;organelle organization#GO:0006996;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of signaling#GO:0023056;supramolecular fiber organization#GO:0097435;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;actin filament-based process#GO:0030029;regulation of cellular process#GO:0050794;cell motility#GO:0048870;positive regulation of cell communication#GO:0010647;actin cytoskeleton organization#GO:0030036;regulation of cell communication#GO:0010646;regulation of hippo signaling#GO:0035330;cellular component organization#GO:0016043;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789 intracellular organelle#GO:0043229;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;actin cytoskeleton#GO:0015629;organelle#GO:0043226;cellular anatomical structure#GO:0110165;actin filament#GO:0005884;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081 cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HUMAN|HGNC=11957|UniProtKB=Q93074 Q93074 MED12 PTHR46007:SF2 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription coactivator activity#GO:0003713 regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of transcription by RNA polymerase II#GO:0045944;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 intracellular organelle#GO:0043229;mediator complex#GO:0016592;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 general transcription factor#PC00259 HUMAN|HGNC=369|UniProtKB=Q9UKA4 Q9UKA4 AKAP11 PTHR10226:SF3 A KINASE ANCHOR PROTEIN A-KINASE ANCHOR PROTEIN 11 binding#GO:0005488;protein kinase A binding#GO:0051018;protein binding#GO:0005515 macromolecule localization#GO:0033036;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;cell surface receptor signaling pathway#GO:0007166;localization#GO:0051179;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;intracellular protein localization#GO:0008104 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 scaffold/adaptor protein#PC00226 HUMAN|HGNC=2214|UniProtKB=Q02388 Q02388 COL7A1 PTHR24023:SF1071 COLLAGEN ALPHA COLLAGEN ALPHA-1(VII) CHAIN extracellular matrix structural constituent#GO:0005201;structural molecule activity#GO:0005198 cellular component organization#GO:0016043;extracellular structure organization#GO:0043062;cellular process#GO:0009987;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840;external encapsulating structure organization#GO:0045229 cellular anatomical structure#GO:0110165;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576;basement membrane#GO:0005604 extracellular matrix protein#PC00102;extracellular matrix structural protein#PC00103 HUMAN|HGNC=14978|UniProtKB=Q9NRS6 Q9NRS6 SNX15 PTHR15508:SF9 RIBOSOMAL PROTEIN S6 KINASE SORTING NEXIN-15 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=21577|UniProtKB=Q8NB78 Q8NB78 KDM1B PTHR10742:SF410 FLAVIN MONOAMINE OXIDASE LYSINE-SPECIFIC HISTONE DEMETHYLASE 2 catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 oxidase#PC00175 HUMAN|HGNC=9983|UniProtKB=P48378 P48378 RFX2 PTHR12619:SF17 RFX TRANSCRIPTION FACTOR FAMILY DNA-BINDING PROTEIN RFX2 RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 cell projection assembly#GO:0030031;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular component assembly#GO:0022607;cellular component organization or biogenesis#GO:0071840;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;cilium assembly#GO:0060271;cell development#GO:0048468;cellular process involved in reproduction in multicellular organism#GO:0022412;regulation of transcription by RNA polymerase II#GO:0006357;cell projection organization#GO:0030030;cell differentiation#GO:0030154;gamete generation#GO:0007276;spermatid differentiation#GO:0048515;cilium organization#GO:0044782;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;regulation of nucleobase-containing compound metabolic process#GO:0019219;male gamete generation#GO:0048232;spermatogenesis#GO:0007283;developmental process#GO:0032502;plasma membrane bounded cell projection assembly#GO:0120031;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;germ cell development#GO:0007281;developmental process involved in reproduction#GO:0003006;reproductive process#GO:0022414;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;sexual reproduction#GO:0019953;spermatid development#GO:0007286;organelle assembly#GO:0070925;regulation of RNA metabolic process#GO:0051252;multicellular organismal reproductive process#GO:0048609;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 winged helix/forkhead transcription factor#PC00246 HUMAN|HGNC=13604|UniProtKB=Q9UJT9 Q9UJT9 FBXL7 PTHR13318:SF50 PARTNER OF PAIRED, ISOFORM B-RELATED F-BOX_LRR-REPEAT PROTEIN 7 HUMAN|HGNC=15983|UniProtKB=P56704 P56704 WNT3A PTHR12027:SF88 WNT RELATED PROTEIN WNT-3A protein binding#GO:0005515;molecular function activator activity#GO:0140677;binding#GO:0005488;signaling receptor binding#GO:0005102;cytokine activity#GO:0005125;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;G protein-coupled receptor binding#GO:0001664;frizzled binding#GO:0005109 neurogenesis#GO:0022008;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;cell surface receptor signaling pathway#GO:0007166;developmental process#GO:0032502;neuron differentiation#GO:0030182;nervous system development#GO:0007399;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;cellular process#GO:0009987;signal transduction#GO:0007165;cell fate commitment#GO:0045165;system development#GO:0048731;anatomical structure development#GO:0048856;canonical Wnt signaling pathway#GO:0060070;cell communication#GO:0007154;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;signaling#GO:0023052;regulation of cellular process#GO:0050794;Wnt signaling pathway#GO:0016055;cell differentiation#GO:0030154;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 Cadherin signaling pathway#P00012>Wnt#P00474;Wnt signaling pathway#P00057>Wnt#P01444;Alzheimer disease-presenilin pathway#P00004>Wnt#P00142 HUMAN|HGNC=30100|UniProtKB=Q9NZ42 Q9NZ42 PSENEN PTHR16318:SF1 GAMMA-SECRETASE SUBUNIT PEN-2 GAMMA-SECRETASE SUBUNIT PEN-2 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;metabolic process#GO:0008152;cellular process#GO:0009987 plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494 Alzheimer disease-amyloid secretase pathway#P00003>Pen-2#P00089;Alzheimer disease-presenilin pathway#P00004>Pen-2#P00149 HUMAN|HGNC=26649|UniProtKB=Q6UWD8 Q6UWD8 C16orf54 PTHR36134:SF1 TRANSMEMBRANE PROTEIN C16ORF54 TRANSMEMBRANE PROTEIN C16ORF54 HUMAN|HGNC=53648|UniProtKB=A0A1W2PR48 A0A1W2PR48 TLE7 PTHR10814:SF33 TRANSDUCIN-LIKE ENHANCER PROTEIN TRANSDUCIN-LIKE ENHANCER PROTEIN 7 transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;negative regulation of Wnt signaling pathway#GO:0030178;negative regulation of response to stimulus#GO:0048585;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of canonical Wnt signaling pathway#GO:0060828;negative regulation of cell communication#GO:0010648;negative regulation of canonical Wnt signaling pathway#GO:0090090;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;regulation of cellular process#GO:0050794;regulation of Wnt signaling pathway#GO:0030111;regulation of cell communication#GO:0010646;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789 membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634 transcription cofactor#PC00217 HUMAN|HGNC=26486|UniProtKB=Q6PJW8 Q6PJW8 CNST PTHR28581:SF1 CONSORTIN CONSORTIN protein binding#GO:0005515;binding#GO:0005488 biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of protein transport#GO:0051223;regulation of biological process#GO:0050789;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of transport#GO:0051050;regulation of protein localization to membrane#GO:1905475;regulation of vesicle-mediated transport#GO:0060627;regulation of protein localization#GO:0032880;regulation of transport#GO:0051049;regulation of establishment of protein localization#GO:0070201;regulation of localization#GO:0032879 endomembrane system#GO:0012505;transport vesicle#GO:0030133;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;plasma membrane#GO:0005886;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;cell periphery#GO:0071944;Golgi apparatus#GO:0005794;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HUMAN|HGNC=19889|UniProtKB=Q9NVX2 Q9NVX2 NLE1 PTHR19848:SF10 WD40 REPEAT PROTEIN NOTCHLESS PROTEIN HOMOLOG 1 regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;regulation of Notch signaling pathway#GO:0008593;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cell communication#GO:0010646 intracellular organelle#GO:0043229;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981 HUMAN|HGNC=3755|UniProtKB=O75369 O75369 FLNB PTHR38537:SF7 JITTERBUG, ISOFORM N FILAMIN-B Integrin signalling pathway#P00034>Filamin#P00914 HUMAN|HGNC=20372|UniProtKB=Q9NX14 Q9NX14 NDUFB11 PTHR13327:SF0 NADH-UBIQUINONE OXIDOREDUCTASE ESSS SUBUNIT, MITOCHONDRIAL PRECURSOR NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 11, MITOCHONDRIAL oxidoreductase complex#GO:1990204;membrane#GO:0016020;membrane protein complex#GO:0098796;respiratory chain complex#GO:0098803;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;respiratory chain complex I#GO:0045271;catalytic complex#GO:1902494;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HUMAN|HGNC=3563|UniProtKB=Q0Z7S8 Q0Z7S8 FABP9 PTHR11955:SF70 FATTY ACID BINDING PROTEIN FATTY ACID-BINDING PROTEIN 9 organic acid binding#GO:0043177;carboxylic acid binding#GO:0031406;small molecule binding#GO:0036094;anion binding#GO:0043168;binding#GO:0005488;ion binding#GO:0043167;lipid binding#GO:0008289;fatty acid binding#GO:0005504 monocarboxylic acid transport#GO:0015718;establishment of localization#GO:0051234;localization#GO:0051179;fatty acid transport#GO:0015908;organic acid transport#GO:0015849;carboxylic acid transport#GO:0046942;transport#GO:0006810;lipid localization#GO:0010876;lipid transport#GO:0006869;macromolecule localization#GO:0033036 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cytosol#GO:0005829;nucleus#GO:0005634;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 transfer/carrier protein#PC00219 HUMAN|HGNC=28143|UniProtKB=Q53S58 Q53S58 TMEM177 PTHR21824:SF4 TRANSMEMBRANE PROTEIN 177 TRANSMEMBRANE PROTEIN 177 cellular anatomical structure#GO:0110165;membrane#GO:0016020 HUMAN|HGNC=12242|UniProtKB=A0A1B0GX51 A0A1B0GX51 TRBV7-8 PTHR23268:SF20 T-CELL RECEPTOR BETA CHAIN T CELL RECEPTOR BETA VARIABLE 7-4-RELATED cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=5389|UniProtKB=P22304 P22304 IDS PTHR45953:SF1 IDURONATE 2-SULFATASE IDURONATE 2-SULFATASE hydrolase activity#GO:0016787;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;lytic vacuole#GO:0000323;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;vacuole#GO:0005773;cellular anatomical structure#GO:0110165;organelle#GO:0043226;lysosome#GO:0005764 HUMAN|HGNC=5301|UniProtKB=P50406 P50406 HTR6 PTHR24247:SF236 5-HYDROXYTRYPTAMINE RECEPTOR 5-HYDROXYTRYPTAMINE RECEPTOR 6 G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;neurotransmitter receptor activity#GO:0030594;transmembrane signaling receptor activity#GO:0004888;G protein-coupled amine receptor activity#GO:0008227 trans-synaptic signaling#GO:0099537;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;chemical synaptic transmission#GO:0007268;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;anterograde trans-synaptic signaling#GO:0098916;signaling#GO:0023052;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;synaptic signaling#GO:0099536;cellular process#GO:0009987;signal transduction#GO:0007165;biological regulation#GO:0065007;cell-cell signaling#GO:0007267 dendrite#GO:0030425;dendritic tree#GO:0097447;membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005;cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;cell projection#GO:0042995 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GsPCR#P00720 HUMAN|HGNC=20712|UniProtKB=Q9NUE0 Q9NUE0 ZDHHC18 PTHR22883:SF257 ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN PALMITOYLTRANSFERASE ZDHHC18 catalytic activity, acting on a protein#GO:0140096;palmitoyltransferase activity#GO:0016409;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746 cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of protein localization to membrane#GO:0090150;protein targeting#GO:0006605;localization within membrane#GO:0051668;protein targeting to membrane#GO:0006612;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 protein modifying enzyme#PC00260 HUMAN|HGNC=19408|UniProtKB=Q86UE6 Q86UE6 LRRTM1 PTHR24373:SF290 SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN LEUCINE-RICH REPEAT TRANSMEMBRANE NEURONAL PROTEIN 1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=26977|UniProtKB=Q8N436 Q8N436 CPXM2 PTHR11532:SF45 PROTEASE M14 CARBOXYPEPTIDASE INACTIVE CARBOXYPEPTIDASE-LIKE PROTEIN X2 metallocarboxypeptidase activity#GO:0004181;hydrolase activity#GO:0016787;exopeptidase activity#GO:0008238;carboxypeptidase activity#GO:0004180;metallopeptidase activity#GO:0008237;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;catalytic activity#GO:0003824;metalloexopeptidase activity#GO:0008235 biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604;protein processing#GO:0016485;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;peptide metabolic process#GO:0006518;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;proteolysis#GO:0006508 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease#PC00190 HUMAN|HGNC=33519|UniProtKB=P0C7M4 P0C7M4 RHOXF2B PTHR24329:SF567 HOMEOBOX PROTEIN ARISTALESS RHOX HOMEOBOX FAMILY MEMBER 2-RELATED sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110 regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;cell development#GO:0048468;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;neuron development#GO:0048666;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;nervous system development#GO:0007399;developmental process#GO:0032502;neuron differentiation#GO:0030182;multicellular organism development#GO:0007275;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=17296|UniProtKB=Q7LG56 Q7LG56 RRM2B PTHR23409:SF19 RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2 B biosynthetic process#GO:0009058;metabolic process#GO:0008152;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262;reductase#PC00198 De novo purine biosynthesis#P02738>ADP reductase#P02902;De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>CDP Reductase#P02915;De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>UDP reductase#P02921;De novo purine biosynthesis#P02738>GDP reductase#P02909 HUMAN|HGNC=33756|UniProtKB=A6NH11 A6NH11 GLTPD2 PTHR10219:SF19 GLYCOLIPID TRANSFER PROTEIN-RELATED GLYCOLIPID TRANSFER PROTEIN DOMAIN-CONTAINING PROTEIN 2 transporter activity#GO:0005215;phospholipid binding#GO:0005543;binding#GO:0005488;anion binding#GO:0043168;small molecule binding#GO:0036094;lipid carrier activity#GO:0005319;ion binding#GO:0043167;molecular carrier activity#GO:0140104;lipid binding#GO:0008289;lipid transfer activity#GO:0120013;phospholipid transfer activity#GO:0120014 localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;intermembrane lipid transfer#GO:0120009;lipid localization#GO:0010876;transport#GO:0006810;lipid transport#GO:0006869;membrane organization#GO:0061024;ceramide transport#GO:0035627;macromolecule localization#GO:0033036;cellular component organization#GO:0016043;nitrogen compound transport#GO:0071705;cellular process#GO:0009987 cytosol#GO:0005829;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 transfer/carrier protein#PC00219 HUMAN|HGNC=24059|UniProtKB=O60235 O60235 TMPRSS11D PTHR24253:SF45 TRANSMEMBRANE PROTEASE SERINE TRANSMEMBRANE PROTEASE SERINE 11D catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;serine hydrolase activity#GO:0017171;serine-type peptidase activity#GO:0008236;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;proteolysis#GO:0006508;metabolic process#GO:0008152;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein processing#GO:0016485 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 protein modifying enzyme#PC00260;serine protease#PC00203;protease#PC00190 HUMAN|HGNC=14556|UniProtKB=Q6EIG7 Q6EIG7 CLEC6A PTHR22802:SF249 C-TYPE LECTIN SUPERFAMILY MEMBER C-TYPE LECTIN DOMAIN FAMILY 6 MEMBER A pattern recognition receptor activity#GO:0038187;carbohydrate binding#GO:0030246;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;binding#GO:0005488 response to stimulus#GO:0050896;defense response to other organism#GO:0098542;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to other organism#GO:0051707;defense response to fungus#GO:0050832;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;immune response#GO:0006955;defense response to symbiont#GO:0140546;innate immune response#GO:0045087;response to external stimulus#GO:0009605;defense response#GO:0006952;immune system process#GO:0002376 membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell surface#GO:0009986;plasma membrane#GO:0005886 membrane traffic protein#PC00150 HUMAN|HGNC=27168|UniProtKB=Q6NUI2 Q6NUI2 GPAT2 PTHR12563:SF15 GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE 2, MITOCHONDRIAL acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity#GO:0016746 lipid metabolic process#GO:0006629;triglyceride metabolic process#GO:0006641;acylglycerol metabolic process#GO:0006639;metabolic process#GO:0008152;neutral lipid metabolic process#GO:0006638;cellular process#GO:0009987;glycerolipid biosynthetic process#GO:0045017;organophosphate metabolic process#GO:0019637;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;glycerophospholipid metabolic process#GO:0006650;triglyceride biosynthetic process#GO:0019432;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;phospholipid metabolic process#GO:0006644;glycerolipid metabolic process#GO:0046486 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739 acyltransferase#PC00042;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=29069|UniProtKB=A6NMS7 A6NMS7 LRRC37A PTHR23045:SF9 LEUCINE-RICH REPEAT-CONTAINING PROTEIN 37A LEUCINE-RICH REPEAT-CONTAINING PROTEIN 37A-RELATED transmembrane signal receptor#PC00197 HUMAN|HGNC=20226|UniProtKB=Q9ULI4 Q9ULI4 KIF26A PTHR21608:SF6 KINESIN-LIKE PROTEIN CG14535 KINESIN-LIKE PROTEIN KIF26A protein binding#GO:0005515;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;microtubule binding#GO:0008017 regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of cell motility#GO:2000145;regulation of cell migration#GO:0030334;regulation of cell projection organization#GO:0031344;regulation of neuron migration#GO:2001222;regulation of locomotion#GO:0040012;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of neuron projection development#GO:0010975;regulation of biological process#GO:0050789 HUMAN|HGNC=4603|UniProtKB=P19875 P19875 CXCL2 PTHR12015:SF206 SMALL INDUCIBLE CYTOKINE A C-X-C MOTIF CHEMOKINE 2 cytokine#PC00083 CCKR signaling map#P06959>CXCL2#G07265;CCKR signaling map#P06959>CXCL2#G06972 HUMAN|Gene=YB003_HUMAN|UniProtKB=Q6UY13 Q6UY13 UNQ5830_PRO19650_PRO19816 PTHR11471:SF3 TUMOR NECROSIS FACTOR FAMILY MEMBER TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 11 molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;cytokine activity#GO:0005125 regulation of developmental process#GO:0050793;positive regulation of apoptotic signaling pathway#GO:2001235;regulation of cell communication#GO:0010646;positive regulation of cell communication#GO:0010647;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;regulation of extrinsic apoptotic signaling pathway#GO:2001236;regulation of hemopoiesis#GO:1903706;cell communication#GO:0007154;regulation of apoptotic signaling pathway#GO:2001233;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of response to stimulus#GO:0048584;positive regulation of myeloid cell differentiation#GO:0045639;positive regulation of cellular process#GO:0048522;regulation of canonical NF-kappaB signal transduction#GO:0043122;regulation of cell development#GO:0060284;positive regulation of extrinsic apoptotic signaling pathway#GO:2001238;positive regulation of developmental process#GO:0051094;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;regulation of cell differentiation#GO:0045595;signaling#GO:0023052;response to stimulus#GO:0050896;positive regulation of programmed cell death#GO:0043068;regulation of biological process#GO:0050789;positive regulation of multicellular organismal process#GO:0051240;regulation of multicellular organismal development#GO:2000026;regulation of programmed cell death#GO:0043067;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;regulation of myeloid cell differentiation#GO:0045637;regulation of intracellular signal transduction#GO:1902531;regulation of multicellular organismal process#GO:0051239;positive regulation of cell development#GO:0010720;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;positive regulation of immune system process#GO:0002684;positive regulation of apoptotic process#GO:0043065;positive regulation of canonical NF-kappaB signal transduction#GO:0043123;positive regulation of cell differentiation#GO:0045597;cell surface receptor signaling pathway#GO:0007166;regulation of apoptotic process#GO:0042981 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HUMAN|HGNC=15583|UniProtKB=Q6UWM7 Q6UWM7 LCTL PTHR10353:SF336 GLYCOSYL HYDROLASE LACTASE-LIKE PROTEIN beta-glucosidase activity#GO:0008422;glucosidase activity#GO:0015926;catalytic activity#GO:0003824;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;hydrolase activity#GO:0016787;hydrolase activity, acting on glycosyl bonds#GO:0016798 metabolite interconversion enzyme#PC00262;glycosidase#PC00110;hydrolase#PC00121 HUMAN|HGNC=4402|UniProtKB=P50151 P50151 GNG10 PTHR13809:SF6 GUANINE NUCLEOTIDE-BINDING PROTEIN GAMMA SUBUNIT GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)_G(S)_G(O) SUBUNIT GAMMA-10 GTPase activity#GO:0003924;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;hydrolase activity#GO:0016787;hydrolase activity, acting on acid anhydrides#GO:0016817;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;molecular function regulator activity#GO:0098772;ribonucleoside triphosphate phosphatase activity#GO:0017111 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 extrinsic component of membrane#GO:0019898;extrinsic component of plasma membrane#GO:0019897;side of membrane#GO:0098552;catalytic complex#GO:1902494;extrinsic component of cytoplasmic side of plasma membrane#GO:0031234;cytoplasmic side of membrane#GO:0098562;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;cytoplasmic side of plasma membrane#GO:0009898;membrane#GO:0016020 heterotrimeric G-protein#PC00117 Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>G-Protein#P01085;Oxytocin receptor mediated signaling pathway#P04391>G-Protein#P04534;Cortocotropin releasing factor receptor signaling pathway#P04380>G-Protein#P04458;Opioid proopiomelanocortin pathway#P05917>G-protein#P06012;5HT4 type receptor mediated signaling pathway#P04376>G-protein#P04430;Metabotropic glutamate receptor group III pathway#P00039>G-Protein#P01045;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>G-Protein#P01073;Enkephalin release#P05913>G-Protein (s)#P05977;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Gbetagamma#P00836;Angiotensin II-stimulated signaling through G proteins and beta-arrestin#P05911>Ggamma#P05929;Enkephalin release#P05913>G-Protein (i)#P05974;5HT2 type receptor mediated signaling pathway#P04374>G-protein#P04416;Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction#P00028>Ggamma#P00751;Thyrotropin-releasing hormone receptor signaling pathway#P04394>G-Protein#P04584;5HT1 type receptor mediated signaling pathway#P04373>G-protein#P04408;GABA-B receptor II signaling#P05731>Ggamma#P05754;Histamine H1 receptor mediated signaling pathway#P04385>G-Protein#P04488;Opioid proenkephalin pathway#P05915>G-protein#P05994;Beta2 adrenergic receptor signaling pathway#P04378>G-Protein#P04443;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>Ggamma#P00721;Histamine H2 receptor mediated signaling pathway#P04386>G-Protein#P04490;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GIRK#P00743;Endogenous cannabinoid signaling#P05730>Ggamma#P05744;Wnt signaling pathway#P00057>Ggamma#P01465;Metabotropic glutamate receptor group II pathway#P00040>G-protein#P01047;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>Ggamma#P00726;Beta3 adrenergic receptor signaling pathway#P04379>G-Protein#P04448;Beta1 adrenergic receptor signaling pathway#P04377>G-Protein#P04436;Opioid prodynorphin pathway#P05916>G-protein#P06002 HUMAN|HGNC=16769|UniProtKB=Q9BQQ3 Q9BQQ3 GORASP1 PTHR12893:SF2 GOLGI REASSEMBLY STACKING PROTEIN GRASP GOLGI REASSEMBLY-STACKING PROTEIN 1 endomembrane system organization#GO:0010256;cellular component organization or biogenesis#GO:0071840;Golgi organization#GO:0007030;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 HUMAN|HGNC=8948|UniProtKB=P29622 P29622 SERPINA4 PTHR11461:SF194 SERINE PROTEASE INHIBITOR, SERPIN KALLISTATIN endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772;enzyme inhibitor activity#GO:0004857;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;serine-type endopeptidase inhibitor activity#GO:0004867;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;peptidase regulator activity#GO:0061134 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HUMAN|HGNC=9531|UniProtKB=P25787 P25787 PSMA2 PTHR11599:SF16 PROTEASOME SUBUNIT ALPHA/BETA PROTEASOME SUBUNIT ALPHA TYPE-2 ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;proteasomal protein catabolic process#GO:0010498;catabolic process#GO:0009056;modification-dependent protein catabolic process#GO:0019941;cellular process#GO:0009987;primary metabolic process#GO:0044238 catalytic complex#GO:1902494;endopeptidase complex#GO:1905369;proteasome complex#GO:0000502;protein-containing complex#GO:0032991;peptidase complex#GO:1905368;intracellular protein-containing complex#GO:0140535 protein modifying enzyme#PC00260;protease#PC00190 Parkinson disease#P00049>20S proteasome#P01227 HUMAN|HGNC=25483|UniProtKB=Q9BSJ6 Q9BSJ6 PIMREG PTHR35819:SF1 PICALM INTERACTING MITOTIC REGULATOR PIMREG PROTEIN PIMREG HUMAN|HGNC=53853|UniProtKB=P0DW14 P0DW14 TAF11L10 PTHR13218:SF18 TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11-RELATED TATA-BOX-BINDING PROTEIN-ASSOCIATED FACTOR 11-LIKE PROTEIN 10-RELATED protein-containing complex assembly#GO:0065003;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;RNA polymerase II preinitiation complex assembly#GO:0051123;DNA-templated transcription initiation#GO:0006352;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;transcription initiation at RNA polymerase II promoter#GO:0006367;cellular component biogenesis#GO:0044085;biosynthetic process#GO:0009058;protein-DNA complex assembly#GO:0065004;nucleobase-containing compound metabolic process#GO:0006139;cellular component assembly#GO:0022607;gene expression#GO:0010467;transcription by RNA polymerase II#GO:0006366;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;protein-containing complex organization#GO:0043933;protein-DNA complex organization#GO:0071824;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170 intracellular anatomical structure#GO:0005622;DNA-directed RNA polymerase complex#GO:0000428;membrane-bounded organelle#GO:0043227;RNA polymerase II, holoenzyme#GO:0016591;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear DNA-directed RNA polymerase complex#GO:0055029;organelle lumen#GO:0043233;intracellular protein-containing complex#GO:0140535;transcription regulator complex#GO:0005667;nuclear protein-containing complex#GO:0140513;transferase complex#GO:1990234;transcription factor TFIID complex#GO:0005669;protein-containing complex#GO:0032991;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;membrane-enclosed lumen#GO:0031974;RNA polymerase II transcription regulator complex#GO:0090575 RNA metabolism protein#PC00031;general transcription factor#PC00259 HUMAN|HGNC=25916|UniProtKB=Q5VSL9 Q5VSL9 STRIP1 PTHR13239:SF7 PROTEIN REQUIRED FOR HYPHAL ANASTOMOSIS HAM-2 STRIATIN-INTERACTING PROTEIN 1 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 cellular component organization or biogenesis#GO:0071840;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;negative regulation of response to stimulus#GO:0048585;negative regulation of signal transduction#GO:0009968;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;regulation of signal transduction#GO:0009966;organelle organization#GO:0006996;cellular process#GO:0009987;negative regulation of hippo signaling#GO:0035331;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;regulation of hippo signaling#GO:0035330;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=1976|UniProtKB=O60543 O60543 CIDEA PTHR12306:SF8 CELL DEATH ACTIVATOR CIDE LIPID TRANSFERASE CIDEA lipid transfer activity#GO:0120013;lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104;transporter activity#GO:0005215 cellular component organization or biogenesis#GO:0071840;lipid droplet organization#GO:0034389;organelle fusion#GO:0048284;programmed cell death#GO:0012501;cellular component organization#GO:0016043;organelle organization#GO:0006996;cell death#GO:0008219;apoptotic process#GO:0006915;cellular process#GO:0009987;lipid storage#GO:0019915 intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membraneless organelle#GO:0043228;lipid droplet#GO:0005811;intracellular membraneless organelle#GO:0043232;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=9284|UniProtKB=Q96QC0 Q96QC0 PPP1R10 PTHR46557:SF1 SERINE/THREONINE-PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 10-RELATED SERINE_THREONINE-PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 10 binding#GO:0005488;phosphatase binding#GO:0019902;enzyme binding#GO:0019899;protein binding#GO:0005515;protein phosphatase binding#GO:0019903 chromosome#GO:0005694;chromatin#GO:0000785;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;intracellular organelle#GO:0043229;protein serine/threonine phosphatase complex#GO:0008287;catalytic complex#GO:1902494;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 protein-binding activity modulator#PC00095;phosphatase modulator#PC00184 HUMAN|HGNC=5346|UniProtKB=P32942 P32942 ICAM3 PTHR13771:SF17 INTERCELLULAR ADHESION MOLECULE INTERCELLULAR ADHESION MOLECULE 3 signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546 cellular process#GO:0009987;cell adhesion mediated by integrin#GO:0033627;cell adhesion#GO:0007155;leukocyte cell-cell adhesion#GO:0007159;cell-cell adhesion#GO:0098609 cell periphery#GO:0071944;extracellular region#GO:0005576;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 cell adhesion molecule#PC00069 HUMAN|HGNC=5980|UniProtKB=Q14005 Q14005 IL16 PTHR48484:SF2 PRO-INTERLEUKIN-16 PRO-INTERLEUKIN-16 cytokine activity#GO:0005125;signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515;molecular function activator activity#GO:0140677;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546 Interleukin signaling pathway#P00036>Interleukin#P00970 HUMAN|HGNC=25734|UniProtKB=Q8WV60 Q8WV60 PTCD2 PTHR14700:SF0 PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 2, MITOCHONDRIAL PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 2, MITOCHONDRIAL regulation of primary metabolic process#GO:0080090;organelle organization#GO:0006996;cellular component organization#GO:0016043;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;cellular process#GO:0009987;regulation of mRNA processing#GO:0050684;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;mitochondrion organization#GO:0007005;biological regulation#GO:0065007;cellular component organization or biogenesis#GO:0071840;regulation of mRNA metabolic process#GO:1903311;regulation of RNA metabolic process#GO:0051252 mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=18156|UniProtKB=Q8WXI4 Q8WXI4 ACOT11 PTHR11049:SF1 ACYL COENZYME A THIOESTER HYDROLASE ACYL-COENZYME A THIOESTERASE 11 hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;thiolester hydrolase activity#GO:0016790;acyl-CoA hydrolase activity#GO:0016289;fatty acyl-CoA hydrolase activity#GO:0047617;catalytic activity#GO:0003824;deacylase activity#GO:0160215 metabolic process#GO:0008152;acyl-CoA metabolic process#GO:0006637;nucleobase-containing small molecule metabolic process#GO:0055086;purine-containing compound metabolic process#GO:0072521;cellular process#GO:0009987;primary metabolic process#GO:0044238;sulfur compound metabolic process#GO:0006790;phosphorus metabolic process#GO:0006793;organophosphate metabolic process#GO:0019637;nucleoside phosphate metabolic process#GO:0006753;nucleobase-containing compound metabolic process#GO:0006139;small molecule metabolic process#GO:0044281 cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 esterase#PC00097 HUMAN|HGNC=8125|UniProtKB=O15527 O15527 OGG1 PTHR10242:SF2 8-OXOGUANINE DNA GLYCOSYLASE N-GLYCOSYLASE_DNA LYASE catalytic activity, acting on DNA#GO:0140097;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787;DNA N-glycosylase activity#GO:0019104;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 macromolecule metabolic process#GO:0043170;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;DNA repair#GO:0006281;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139;response to stress#GO:0006950;primary metabolic process#GO:0044238;base-excision repair#GO:0006284;nucleic acid metabolic process#GO:0090304;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA metabolism protein#PC00009 HUMAN|HGNC=29001|UniProtKB=O14524 O14524 NEMP1 PTHR13598:SF2 AT07567P-RELATED NUCLEAR ENVELOPE INTEGRAL MEMBRANE PROTEIN 1 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;organelle envelope#GO:0031967;nucleus#GO:0005634 HUMAN|HGNC=26563|UniProtKB=Q96M02 Q96M02 C10orf90 PTHR21553:SF24 ALMS1-RELATED (E2-INDEPENDENT) E3 UBIQUITIN-CONJUGATING ENZYME FATS transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659 regulation of cellular component biogenesis#GO:0044087;regulation of cell cycle process#GO:0010564;regulation of cell cycle#GO:0051726;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of organelle assembly#GO:1902115;regulation of microtubule-based process#GO:0032886 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;centrosome#GO:0005813;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;centriole#GO:0005814;cytosol#GO:0005829;microtubule cytoskeleton#GO:0015630 HUMAN|HGNC=26235|UniProtKB=Q9H5X1 Q9H5X1 CIAO2A PTHR12377:SF6 CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B-RELATED CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2A macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535 HUMAN|HGNC=14963|UniProtKB=Q96P66 Q96P66 GPR101 PTHR24248:SF176 ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR G PROTEIN-COUPLED RECEPTOR 101-RELATED molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cell communication#GO:0007154;adrenergic receptor signaling pathway#GO:0071875;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HUMAN|HGNC=28904|UniProtKB=Q9BQI0 Q9BQI0 AIF1L PTHR10356:SF5 ALLOGRAFT INFLAMMATORY FACTOR-1 ALLOGRAFT INFLAMMATORY FACTOR 1-LIKE actin filament binding#GO:0051015;calcium ion binding#GO:0005509;actin binding#GO:0003779;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;cation binding#GO:0043169;protein-containing complex binding#GO:0044877;protein binding#GO:0005515;metal ion binding#GO:0046872;cytoskeletal protein binding#GO:0008092 plasma membrane bounded cell projection assembly#GO:0120031;actin filament organization#GO:0007015;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cell projection assembly#GO:0030031;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;actin filament-based process#GO:0030029;supramolecular fiber organization#GO:0097435;actin filament bundle organization#GO:0061572;actin filament bundle assembly#GO:0051017;cellular component organization#GO:0016043;actin cytoskeleton organization#GO:0030036;cell projection organization#GO:0030030 polymeric cytoskeletal fiber#GO:0099513;ruffle#GO:0001726;membraneless organelle#GO:0043228;ruffle membrane#GO:0032587;cytoskeleton#GO:0005856;actin filament#GO:0005884;supramolecular polymer#GO:0099081;plasma membrane region#GO:0098590;supramolecular complex#GO:0099080;plasma membrane#GO:0005886;intracellular membraneless organelle#GO:0043232;membrane#GO:0016020;cell leading edge#GO:0031252;cell periphery#GO:0071944;cell projection membrane#GO:0031253;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;leading edge membrane#GO:0031256;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;actin cytoskeleton#GO:0015629 calcium-binding protein#PC00060;calmodulin-related#PC00061 HUMAN|Ensembl=ENSG00000236543.3|UniProtKB=A0A1B0GUV8 A0A1B0GUV8 LOC102723971 PTHR11430:SF120 LIPOCALIN LIPOCALIN_CYTOSOLIC FATTY-ACID BINDING DOMAIN-CONTAINING PROTEIN cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 transfer/carrier protein#PC00219 HUMAN|HGNC=18546|UniProtKB=Q9UKY3 Q9UKY3 CES1P1 PTHR11559:SF441 CARBOXYLESTERASE LIVER CARBOXYLESTERASE 1-RELATED hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;carboxylic ester hydrolase activity#GO:0052689;catalytic activity#GO:0003824 oxoacid metabolic process#GO:0043436;fatty acid catabolic process#GO:0009062;short-chain fatty acid catabolic process#GO:0019626;monocarboxylic acid metabolic process#GO:0032787;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;small molecule catabolic process#GO:0044282;catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;fatty acid metabolic process#GO:0006631;lipid catabolic process#GO:0016042;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;monocarboxylic acid catabolic process#GO:0072329 membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;lipid droplet#GO:0005811;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232 esterase#PC00097 HUMAN|HGNC=6597|UniProtKB=P42702 P42702 LIFR PTHR23036:SF105 CYTOKINE RECEPTOR LEUKEMIA INHIBITORY FACTOR RECEPTOR immune receptor activity#GO:0140375;cytokine binding#GO:0019955;signaling receptor activity#GO:0038023;cytokine receptor activity#GO:0004896;molecular transducer activity#GO:0060089;protein binding#GO:0005515;binding#GO:0005488;cytokine receptor binding#GO:0005126;signaling receptor binding#GO:0005102;transmembrane signaling receptor activity#GO:0004888 cell surface receptor signaling pathway#GO:0007166;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165;biological regulation#GO:0065007;response to cytokine#GO:0034097;response to chemical#GO:0042221;cytokine-mediated signaling pathway#GO:0019221;response to peptide#GO:1901652;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;cellular response to stimulus#GO:0051716;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;positive regulation of cell population proliferation#GO:0008284;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;signaling receptor complex#GO:0043235 transmembrane signal receptor#PC00197 HUMAN|HGNC=17042|UniProtKB=Q9UHX1 Q9UHX1 PUF60 PTHR47330:SF1 POLY(U)-BINDING-SPLICING FACTOR PUF60-B-RELATED POLY(U)-BINDING-SPLICING FACTOR PUF60 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;nucleobase-containing compound metabolic process#GO:0006139;regulation of RNA splicing#GO:0043484;biosynthetic process#GO:0009058;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of mRNA processing#GO:0050684;RNA splicing, via transesterification reactions#GO:0000375;regulation of RNA metabolic process#GO:0051252;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;protein-RNA complex assembly#GO:0022618;regulation of mRNA splicing, via spliceosome#GO:0048024;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;protein-containing complex organization#GO:0043933;regulation of mRNA metabolic process#GO:1903311;protein-RNA complex organization#GO:0071826;cellular component organization or biogenesis#GO:0071840;alternative mRNA splicing, via spliceosome#GO:0000380;cellular process#GO:0009987;mRNA processing#GO:0006397;cellular component biogenesis#GO:0044085;RNA processing#GO:0006396;mRNA splice site recognition#GO:0006376;gene expression#GO:0010467;cellular component assembly#GO:0022607;spliceosomal complex assembly#GO:0000245;nucleic acid biosynthetic process#GO:0141187;regulation of alternative mRNA splicing, via spliceosome#GO:0000381;RNA metabolic process#GO:0016070;regulation of biological process#GO:0050789;protein-containing complex assembly#GO:0065003;mRNA splicing, via spliceosome#GO:0000398;cellular component organization#GO:0016043;ribonucleoprotein complex biogenesis#GO:0022613;mRNA metabolic process#GO:0016071 RNA splicing factor#PC00148 HUMAN|HGNC=8742|UniProtKB=P48539 P48539 PCP4 PTHR15359:SF7 IG-LIKE DOMAIN-CONTAINING PROTEIN CALMODULIN REGULATOR PROTEIN PCP4 calmodulin binding#GO:0005516;cation binding#GO:0043169;protein binding#GO:0005515;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 Gonadotropin-releasing hormone receptor pathway#P06664>MAP3Ks#P06834 HUMAN|HGNC=28744|UniProtKB=Q6PI25 Q6PI25 CNIH2 PTHR12290:SF13 CORNICHON-RELATED PROTEIN CORNICHON HOMOLOG 2 trans-synaptic signaling#GO:0099537;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;cellular localization#GO:0051641;cell communication#GO:0007154;localization#GO:0051179;regulation of biological process#GO:0050789;chemical synaptic transmission#GO:0007268;signaling#GO:0023052;anterograde trans-synaptic signaling#GO:0098916;Golgi vesicle transport#GO:0048193;transport#GO:0006810;intracellular transport#GO:0046907;establishment of localization#GO:0051234;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;synaptic signaling#GO:0099536;synaptic transmission, glutamatergic#GO:0035249;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;vesicle-mediated transport#GO:0016192 vesicle#GO:0031982;intracellular vesicle#GO:0097708;cell projection#GO:0042995;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165;synapse#GO:0045202;endoplasmic reticulum subcompartment#GO:0098827;dendritic tree#GO:0097447;intracellular organelle#GO:0043229;dendrite#GO:0030425;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;coated vesicle#GO:0030135;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;COPII-coated ER to Golgi transport vesicle#GO:0030134;neuron projection#GO:0043005;membrane#GO:0016020;somatodendritic compartment#GO:0036477;cytoplasm#GO:0005737;endomembrane system#GO:0012505;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;cell junction#GO:0030054 membrane traffic protein#PC00150 HUMAN|HGNC=1012|UniProtKB=P03999 P03999 OPN1SW PTHR24240:SF16 OPSIN SHORT-WAVE-SENSITIVE OPSIN 1 molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;response to light stimulus#GO:0009416;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;cellular response to environmental stimulus#GO:0104004;cellular response to radiation#GO:0071478;signaling#GO:0023052;response to abiotic stimulus#GO:0009628;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular response to abiotic stimulus#GO:0071214;response to external stimulus#GO:0009605;biological regulation#GO:0065007;detection of stimulus#GO:0051606;signal transduction#GO:0007165;response to radiation#GO:0009314;cellular response to light stimulus#GO:0071482;cellular process#GO:0009987 cilium#GO:0005929;membrane-bounded organelle#GO:0043227;non-motile cilium#GO:0097730;neuron projection#GO:0043005;cell periphery#GO:0071944;photoreceptor cell cilium#GO:0097733;9+0 non-motile cilium#GO:0097731;membrane#GO:0016020;plasma membrane#GO:0005886;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;photoreceptor outer segment#GO:0001750;organelle#GO:0043226;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021 HUMAN|HGNC=16395|UniProtKB=Q9BXB5 Q9BXB5 OSBPL10 PTHR10972:SF47 OXYSTEROL-BINDING PROTEIN-RELATED OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 10 alcohol binding#GO:0043178;steroid binding#GO:0005496;cholesterol binding#GO:0015485;lipid binding#GO:0008289;binding#GO:0005488;small molecule binding#GO:0036094;sterol binding#GO:0032934 membrane#GO:0016020;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 transfer/carrier protein#PC00219 HUMAN|HGNC=9480|UniProtKB=Q9NQE7 Q9NQE7 PRSS16 PTHR11010:SF123 PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED THYMUS-SPECIFIC SERINE PROTEASE intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;lytic vacuole#GO:0000323;vesicle#GO:0031982;lysosome#GO:0005764;intracellular vesicle#GO:0097708;vacuole#GO:0005773;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 serine protease#PC00203 HUMAN|HGNC=25470|UniProtKB=Q5VX71 Q5VX71 SUSD4 PTHR47007:SF1 SUSHI DOMAIN-CONTAINING PROTEIN 4 SUSHI DOMAIN-CONTAINING PROTEIN 4 HUMAN|HGNC=29278|UniProtKB=Q9BQW3 Q9BQW3 EBF4 PTHR10747:SF36 TRANSCRIPTION FACTOR COE FAMILY MEMBER TRANSCRIPTION FACTOR COE4 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 P53-like transcription factor#PC00253;DNA-binding transcription factor#PC00218 HUMAN|HGNC=18333|UniProtKB=Q4W5G0 Q4W5G0 TIGD2 PTHR19303:SF22 TRANSPOSON TIGGER TRANSPOSABLE ELEMENT-DERIVED PROTEIN 2 binding#GO:0005488;nucleic acid binding#GO:0003676;DNA binding#GO:0003677 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 viral or transposable element protein#PC00237 HUMAN|HGNC=17565|UniProtKB=Q8N4C8 Q8N4C8 MINK1 PTHR48015:SF11 SERINE/THREONINE-PROTEIN KINASE TAO MISSHAPEN-LIKE KINASE 1 catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;protein serine/threonine kinase activity#GO:0004674 intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of response to stimulus#GO:0048583;regulation of MAPK cascade#GO:0043408;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of cell communication#GO:0010646;signaling#GO:0023052;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cell communication#GO:0007154;MAPK cascade#GO:0000165;intracellular signal transduction#GO:0035556;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=37258|UniProtKB=C9J202 C9J202 ALG1L2 PTHR13036:SF2 BETA1,4 MANNOSYLTRANSFERASE GLYCOSYLTRANSFERASE ALG1L2-RELATED hexosyltransferase activity#GO:0016758;catalytic activity#GO:0003824;transferase activity#GO:0016740;mannosyltransferase activity#GO:0000030;glycosyltransferase activity#GO:0016757 macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538;glycoprotein metabolic process#GO:0009100;metabolic process#GO:0008152;biosynthetic process#GO:0009058;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 glycosyltransferase#PC00111 HUMAN|HGNC=17976|UniProtKB=Q96L21 Q96L21 RPL10L PTHR11726:SF29 60S RIBOSOMAL PROTEIN L10 RIBOSOMAL PROTEIN UL16-LIKE structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;meiotic nuclear division#GO:0140013;metabolic process#GO:0008152;meiotic cell cycle#GO:0051321;spermatogenesis#GO:0007283;developmental process#GO:0032502;male gamete generation#GO:0048232;gene expression#GO:0010467;male meiotic nuclear division#GO:0007140;biosynthetic process#GO:0009058;organelle organization#GO:0006996;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein metabolic process#GO:0019538;organelle fission#GO:0048285;multicellular organismal reproductive process#GO:0048609;meiosis I cell cycle process#GO:0061982;nuclear division#GO:0000280;sexual reproduction#GO:0019953;translation#GO:0006412;protein biosynthetic process#GO:0160307;gamete generation#GO:0007276;reproductive process#GO:0022414;cell cycle#GO:0007049;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;developmental process involved in reproduction#GO:0003006;meiotic cell cycle process#GO:1903046;meiosis I#GO:0007127;cell cycle process#GO:0022402 cytoplasm#GO:0005737;ribosomal subunit#GO:0044391;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;cytosolic large ribosomal subunit#GO:0022625;cytosolic ribosome#GO:0022626;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;large ribosomal subunit#GO:0015934;ribonucleoprotein complex#GO:1990904 ribosomal protein#PC00202;translational protein#PC00263 HUMAN|HGNC=26275|UniProtKB=Q6PEZ8 Q6PEZ8 PODNL1 PTHR45712:SF5 AGAP008170-PA PODOCAN-LIKE PROTEIN 1 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=19320|UniProtKB=Q08708 Q08708 CD300C PTHR11860:SF107 POLYMERIC-IMMUNOGLOBULIN RECEPTOR CMRF35-LIKE MOLECULE 6 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of response to biotic stimulus#GO:0002831;signaling#GO:0023052;regulation of defense response#GO:0031347;regulation of immune response#GO:0050776;cell communication#GO:0007154;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of response to external stimulus#GO:0032101;biological regulation#GO:0065007;regulation of response to stress#GO:0080134;regulation of response to stimulus#GO:0048583;regulation of innate immune response#GO:0045088 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=18334|UniProtKB=Q6B0B8 Q6B0B8 TIGD3 PTHR19303:SF36 TRANSPOSON TIGGER TRANSPOSABLE ELEMENT-DERIVED PROTEIN 3 nucleic acid binding#GO:0003676;binding#GO:0005488;DNA binding#GO:0003677 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 viral or transposable element protein#PC00237 HUMAN|HGNC=33842|UniProtKB=Q4LEZ3 Q4LEZ3 AARD PTHR32289:SF2 PROTEIN FAM167A ALANINE- AND ARGININE-RICH DOMAIN-CONTAINING PROTEIN response to stimulus#GO:0050896;response to chemical#GO:0042221;response to lipid#GO:0033993;response to oxygen-containing compound#GO:1901700 HUMAN|HGNC=7587|UniProtKB=P60660 P60660 MYL6 PTHR23048:SF43 MYOSIN LIGHT CHAIN 1, 3 MYOSIN LIGHT POLYPEPTIDE 6 ATP-dependent activity#GO:0140657;polypeptide conformation or assembly isomerase activity#GO:0120544;isomerase activity#GO:0016853;structural molecule activity#GO:0005198;cytoskeletal motor activity#GO:0003774;macromolecular conformation isomerase activity#GO:0120543;catalytic activity#GO:0003824;microfilament motor activity#GO:0000146 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;myosin complex#GO:0016459;actin cytoskeleton#GO:0015629;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=5617|UniProtKB=A0A075B6Q5 A0A075B6Q5 IGHV3-64 PTHR23266:SF372 IMMUNOGLOBULIN HEAVY CHAIN IMMUNOGLOBULIN HEAVY VARIABLE 3-23-RELATED antigen binding#GO:0003823;binding#GO:0005488 immune response#GO:0006955;adaptive immune response#GO:0002250;response to stimulus#GO:0050896;immune effector process#GO:0002252;immune system process#GO:0002376;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;immunoglobulin mediated immune response#GO:0016064;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=23319|UniProtKB=Q9Y2I2 Q9Y2I2 NTNG1 PTHR10574:SF28 NETRIN/LAMININ-RELATED NETRIN-G1 cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell morphogenesis#GO:0000902;cell development#GO:0048468;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;anatomical structure development#GO:0048856;system development#GO:0048731;axonogenesis#GO:0007409;neuron development#GO:0048666;neuron projection development#GO:0031175;axon development#GO:0061564;cellular process#GO:0009987;multicellular organismal process#GO:0032501;tissue development#GO:0009888;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cell morphogenesis involved in neuron differentiation#GO:0048667;developmental process#GO:0032502;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron projection morphogenesis#GO:0048812;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;cell projection morphogenesis#GO:0048858;neurogenesis#GO:0022008 extracellular matrix protein#PC00102 Axon guidance mediated by Slit/Robo#P00008>Netrin#P00344;Axon guidance mediated by netrin#P00009>Netrin#P00357 HUMAN|HGNC=1530|UniProtKB=Q9BPX6 Q9BPX6 MICU1 PTHR12294:SF1 EF HAND DOMAIN FAMILY A1,A2-RELATED CALCIUM UPTAKE PROTEIN 1, MITOCHONDRIAL binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;calcium ion binding#GO:0005509;metal ion binding#GO:0046872;cation binding#GO:0043169 establishment of localization#GO:0051234;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;calcium ion transport#GO:0006816;cellular homeostasis#GO:0019725;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;transport#GO:0006810;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220;mitochondrial calcium ion transmembrane transport#GO:0006851;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;localization#GO:0051179;monoatomic cation transport#GO:0006812;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;calcium ion homeostasis#GO:0055074;inorganic ion homeostasis#GO:0098771;mitochondrial calcium ion homeostasis#GO:0051560;metal ion transport#GO:0030001;homeostatic process#GO:0042592;intracellular monoatomic ion homeostasis#GO:0006873;calcium ion transmembrane transport#GO:0070588 transmembrane transporter complex#GO:1902495;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;organelle envelope#GO:0031967;mitochondrion#GO:0005739;calcium channel complex#GO:0034704;transporter complex#GO:1990351;organelle membrane#GO:0031090;cation channel complex#GO:0034703;inner mitochondrial membrane protein complex#GO:0098800;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;cytoplasm#GO:0005737;mitochondrial inner membrane#GO:0005743;membrane#GO:0016020;mitochondrial membrane#GO:0031966;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740 calcium-binding protein#PC00060;calmodulin-related#PC00061 HUMAN|HGNC=15353|UniProtKB=Q8NH41 Q8NH41 OR4K15 PTHR48002:SF109 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 4K15 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=11575|UniProtKB=Q86VP1 Q86VP1 TAX1BP1 PTHR31915:SF8 SKICH DOMAIN-CONTAINING PROTEIN TAX1-BINDING PROTEIN 1 regulation of cellular process#GO:0050794;negative regulation of apoptotic process#GO:0043066;biological regulation#GO:0065007;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;negative regulation of programmed cell death#GO:0043069;regulation of biological process#GO:0050789;negative regulation of cellular process#GO:0048523;regulation of apoptotic process#GO:0042981 HUMAN|HGNC=18541|UniProtKB=Q8IZD2 Q8IZD2 KMT2E PTHR46462:SF2 UPSET, ISOFORM A HISTONE READER KMT2E regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 chromosome#GO:0005694;organelle lumen#GO:0043233;nucleoplasm#GO:0005654;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;Rpd3L-Expanded complex#GO:0070210;intracellular anatomical structure#GO:0005622;histone deacetylase complex#GO:0000118;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;chromatin#GO:0000785;protein-containing complex#GO:0032991;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228 HUMAN|HGNC=30163|UniProtKB=O60678 O60678 PRMT3 PTHR11006:SF125 PROTEIN ARGININE N-METHYLTRANSFERASE PROTEIN ARGININE N-METHYLTRANSFERASE 3 histone modifying activity#GO:0140993;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;N-methyltransferase activity#GO:0008170;histone methyltransferase activity#GO:0042054;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein methyltransferase activity#GO:0008276 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;chromatin organization#GO:0006325;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;chromatin remodeling#GO:0006338;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 protein modifying enzyme#PC00260 HUMAN|HGNC=28526|UniProtKB=Q5NDL2 Q5NDL2 EOGT PTHR20961:SF148 GLYCOSYLTRANSFERASE EGF DOMAIN-SPECIFIC O-LINKED N-ACETYLGLUCOSAMINE TRANSFERASE glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;transferase activity#GO:0016740 metabolite interconversion enzyme#PC00262;glycosyltransferase#PC00111 HUMAN|HGNC=24525|UniProtKB=Q9Y4U1 Q9Y4U1 MMACHC PTHR31457:SF2 METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE C PROTEIN CYANOCOBALAMIN REDUCTASE _ ALKYLCOBALAMIN DEALKYLASE heterocyclic compound binding#GO:1901363;oxidoreductase activity#GO:0016491;demethylase activity#GO:0032451;nucleotide binding#GO:0000166;oxidoreductase activity, acting on metal ions#GO:0016722;catalytic activity#GO:0003824;ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265;small molecule binding#GO:0036094;binding#GO:0005488;flavin adenine dinucleotide binding#GO:0050660;anion binding#GO:0043168 metabolic process#GO:0008152;tetrapyrrole metabolic process#GO:0033013;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=4845|UniProtKB=O60741 O60741 HCN1 PTHR45689:SF3 I[[H]] CHANNEL, ISOFORM E POTASSIUM_SODIUM HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNEL 1 potassium channel activity#GO:0005267;potassium ion transmembrane transporter activity#GO:0015079;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;monoatomic cation channel activity#GO:0005261;voltage-gated monoatomic ion channel activity#GO:0005244;gated channel activity#GO:0022836;voltage-gated potassium channel activity#GO:0005249;voltage-gated channel activity#GO:0022832;monoatomic cation transmembrane transporter activity#GO:0008324;transporter activity#GO:0005215;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873 sodium ion transport#GO:0006814;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;metal ion transport#GO:0030001;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;cellular process#GO:0009987;sodium ion transmembrane transport#GO:0035725;potassium ion transport#GO:0006813;monoatomic ion transmembrane transport#GO:0034220;biological regulation#GO:0065007;monoatomic cation transmembrane transport#GO:0098655;potassium ion transmembrane transport#GO:0071805;transport#GO:0006810;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234 cation channel complex#GO:0034703;voltage-gated potassium channel complex#GO:0008076;transporter complex#GO:1990351;membrane#GO:0016020;neuron projection#GO:0043005;cell periphery#GO:0071944;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;somatodendritic compartment#GO:0036477;plasma membrane#GO:0005886;dendrite#GO:0030425;axon#GO:0030424;dendritic tree#GO:0097447;transmembrane transporter complex#GO:1902495;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025 ion channel#PC00133;transporter#PC00227 HUMAN|HGNC=33154|UniProtKB=P0C7U0 P0C7U0 ELFN1 PTHR24373:SF288 SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN PROTEIN ELFN1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 regulation of biological process#GO:0050789;cellular process#GO:0009987;synaptic signaling#GO:0099536;chemical synaptic transmission#GO:0007268;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;signaling#GO:0023052;anterograde trans-synaptic signaling#GO:0098916;trans-synaptic signaling#GO:0099537;cell communication#GO:0007154 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=29620|UniProtKB=Q8TBF4 Q8TBF4 ZCRB1 PTHR46259:SF2 ZINC FINGER CCHC-TYPE AND RNA-BINDING MOTIF-CONTAINING PROTEIN 1 ZINC FINGER CCHC-TYPE AND RNA-BINDING MOTIF-CONTAINING PROTEIN 1 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397 spliceosomal complex#GO:0005681;nucleus#GO:0005634;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;U12-type spliceosomal complex#GO:0005689;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=11773|UniProtKB=P37173 P37173 TGFBR2 PTHR23255:SF55 TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II TGF-BETA RECEPTOR TYPE-2 transmembrane receptor protein serine/threonine kinase activity#GO:0004675;growth factor binding#GO:0019838;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein binding#GO:0005515;protein-containing complex binding#GO:0044877;protein kinase activity#GO:0004672;cytokine receptor binding#GO:0005126;binding#GO:0005488;protein serine/threonine kinase activity#GO:0004674;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;transferase activity#GO:0016740;kinase activity#GO:0016301;transforming growth factor beta receptor activity#GO:0005024;activin binding#GO:0048185;molecular transducer activity#GO:0060089;signaling receptor binding#GO:0005102;catalytic activity, acting on a protein#GO:0140096;cytokine binding#GO:0019955;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity#GO:0003824;transforming growth factor beta binding#GO:0050431;transferase activity, transferring phosphorus-containing groups#GO:0016772 cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;signaling#GO:0023052;regulation of cellular process#GO:0050794;cellular response to endogenous stimulus#GO:0071495;circulatory system development#GO:0072359;response to growth factor#GO:0070848;response to stimulus#GO:0050896;activin receptor signaling pathway#GO:0032924;animal gross anatomical part developmental process#GO:0160108;cellular response to growth factor stimulus#GO:0071363;system development#GO:0048731;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;cell communication#GO:0007154;cellular process#GO:0009987;signal transduction#GO:0007165;nervous system development#GO:0007399;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;heart development#GO:0007507;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;cell surface receptor signaling pathway#GO:0007166;developmental process#GO:0032502;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;animal organ development#GO:0048513;multicellular organism development#GO:0007275 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane#GO:0016020;membrane protein complex#GO:0098796;protein kinase complex#GO:1902911;serine/threonine protein kinase complex#GO:1902554;signaling receptor complex#GO:0043235;catalytic complex#GO:1902494;transferase complex#GO:1990234;transferase complex, transferring phosphorus-containing groups#GO:0061695 serine/threonine protein kinase receptor#PC00205 TGF-beta signaling pathway#P00052>TGFbetareceptor II#P01277;TGF-beta signaling pathway#P00052>TGFbetareceptors#P01283 HUMAN|HGNC=29351|UniProtKB=Q9C0H5 Q9C0H5 ARHGAP39 PTHR45876:SF1 FI04035P RHO GTPASE-ACTIVATING PROTEIN 39 enzyme activator activity#GO:0008047;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=286|UniProtKB=P07550 P07550 ADRB2 PTHR24248:SF21 ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR BETA-2 ADRENERGIC RECEPTOR cation binding#GO:0043169;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;G protein-coupled amine receptor activity#GO:0008227 cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;vasodilation#GO:0042311;signaling#GO:0023052;circulatory system process#GO:0003013;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;adrenergic receptor signaling pathway#GO:0071875;regulation of biological quality#GO:0065008;regulation of systemic arterial blood pressure#GO:0003073;regulation of blood pressure#GO:0008217;cellular process#GO:0009987;signal transduction#GO:0007165;multicellular organismal process#GO:0032501;blood circulation#GO:0008015;biological regulation#GO:0065007;regulation of anatomical structure size#GO:0090066;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;system process#GO:0003008 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GsPCR#P00720;Beta2 adrenergic receptor signaling pathway#P04378>Beta2#P04440 HUMAN|HGNC=28504|UniProtKB=Q8TBZ0 Q8TBZ0 CCDC110 PTHR32083:SF32 CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58-RELATED COILED-COIL DOMAIN-CONTAINING PROTEIN 110 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;organelle#GO:0043226;membraneless organelle#GO:0043228;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;intracellular anatomical structure#GO:0005622 structural protein#PC00211 HUMAN|HGNC=33747|UniProtKB=Q8TAL6 Q8TAL6 FIBIN PTHR31185:SF0 FIN BUD INITIATION FACTOR FIBIN FIN BUD INITIATION FACTOR HOMOLOG HUMAN|HGNC=21494|UniProtKB=Q5TF21 Q5TF21 MTCL3 PTHR15742:SF2 GIRDIN MICROTUBULE CROSS-LINKING FACTOR 3 microtubule binding#GO:0008017;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;protein binding#GO:0005515 microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;microtubule#GO:0005874 HUMAN|HGNC=12188|UniProtKB=A0A0A6YYD4 A0A0A6YYD4 TRBV13 PTHR23268:SF75 T-CELL RECEPTOR BETA CHAIN T CELL RECEPTOR BETA VARIABLE 13 cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=1493|UniProtKB=P49589 P49589 CARS1 PTHR10890:SF33 CYSTEINYL-TRNA SYNTHETASE CYSTEINE--TRNA LIGASE, CYTOPLASMIC catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824;ligase activity#GO:0016874;catalytic activity, acting on a tRNA#GO:0140101;catalytic activity, acting on RNA#GO:0140098 amino acid activation#GO:0043038;macromolecule metabolic process#GO:0043170;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;gene expression#GO:0010467;amino acid metabolic process#GO:0006520;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;tRNA aminoacylation#GO:0043039;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;tRNA aminoacylation for protein translation#GO:0006418;RNA metabolic process#GO:0016070;protein metabolic process#GO:0019538;translation#GO:0006412;protein biosynthetic process#GO:0160307;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 HUMAN|HGNC=17021|UniProtKB=O75129 O75129 ASTN2 PTHR16592:SF2 ASTROTACTIN-1-LIKE ASTROTACTIN-2 alcohol binding#GO:0043178;ion binding#GO:0043167;binding#GO:0005488;anion binding#GO:0043168;small molecule binding#GO:0036094 developmental process#GO:0032502;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;neuron migration#GO:0001764;multicellular organism development#GO:0007275;cellular process#GO:0009987;cell-cell adhesion#GO:0098609;nervous system development#GO:0007399;cell migration#GO:0016477;multicellular organismal process#GO:0032501;generation of neurons#GO:0048699;cell adhesion#GO:0007155;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;anatomical structure development#GO:0048856;cell motility#GO:0048870;cell differentiation#GO:0030154 intracellular vesicle#GO:0097708;membrane#GO:0016020;vesicle#GO:0031982;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;endosome#GO:0005768;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410 HUMAN|HGNC=10547|UniProtKB=O75845 O75845 SC5D PTHR11863:SF247 STEROL DESATURASE LATHOSTEROL OXIDASE catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;oxidoreductase activity#GO:0016491 secondary alcohol biosynthetic process#GO:1902653;steroid biosynthetic process#GO:0006694;sterol metabolic process#GO:0016125;cholesterol metabolic process#GO:0008203;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;alcohol metabolic process#GO:0006066;biosynthetic process#GO:0009058;steroid metabolic process#GO:0008202;sterol biosynthetic process#GO:0016126;cholesterol biosynthetic process#GO:0006695;lipid biosynthetic process#GO:0008610;alcohol biosynthetic process#GO:0046165;cellular process#GO:0009987;secondary alcohol metabolic process#GO:1902652;small molecule metabolic process#GO:0044281;primary metabolic process#GO:0044238 membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622 oxidase#PC00175 HUMAN|HGNC=28041|UniProtKB=Q86W34 Q86W34 AMZ2 PTHR32205:SF5 ARCHAEMETZINCIN-2-RELATED ARCHAEMETZINCIN-2 HUMAN|HGNC=29214|UniProtKB=Q3KR37 Q3KR37 GRAMD1B PTHR23319:SF3 GRAM DOMAIN CONTAINING 1B, ISOFORM E PROTEIN ASTER-B transporter activity#GO:0005215;sterol transfer activity#GO:0120015;steroid binding#GO:0005496;cholesterol transfer activity#GO:0120020;alcohol binding#GO:0043178;molecular carrier activity#GO:0140104;sterol binding#GO:0032934;lipid carrier activity#GO:0005319;small molecule binding#GO:0036094;binding#GO:0005488;lipid transfer activity#GO:0120013;lipid binding#GO:0008289;cholesterol binding#GO:0015485 organic hydroxy compound transport#GO:0015850;localization#GO:0051179;cellular localization#GO:0051641;sterol transport#GO:0015918;establishment of localization#GO:0051234;transport#GO:0006810;lipid localization#GO:0010876;intracellular transport#GO:0046907;intracellular sterol transport#GO:0032366;lipid transport#GO:0006869;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;macromolecule localization#GO:0033036 endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;endomembrane system#GO:0012505;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane contact site#GO:0044232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;cellular anatomical structure#GO:0110165 HUMAN|HGNC=28627|UniProtKB=Q8N4U5 Q8N4U5 TCP11L2 PTHR12832:SF17 TESTIS-SPECIFIC PROTEIN PBS13 T-COMPLEX 11 T-COMPLEX PROTEIN 11-LIKE PROTEIN 2 cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052 microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=22206|UniProtKB=Q8NCT3 Q8NCT3 MATCAP2 PTHR31817:SF3 FAMILY NOT NAMED TYROSINE CARBOXYPEPTIDASE MATCAP2-RELATED HUMAN|HGNC=7225|UniProtKB=P25189 P25189 MPZ PTHR13869:SF7 MYELIN P0 RELATED MYELIN PROTEIN P0 cell-cell adhesion#GO:0098609;cellular process#GO:0009987;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502;cell adhesion#GO:0007155;multicellular organism development#GO:0007275;anatomical structure development#GO:0048856;system development#GO:0048731;myelination#GO:0042552 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 myelin protein#PC00161 HUMAN|HGNC=15761|UniProtKB=Q9H1P3 Q9H1P3 OSBPL2 PTHR10972:SF153 OXYSTEROL-BINDING PROTEIN-RELATED OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 2 alcohol binding#GO:0043178;cholesterol binding#GO:0015485;lipid binding#GO:0008289;steroid binding#GO:0005496;small molecule binding#GO:0036094;binding#GO:0005488;sterol binding#GO:0032934 membrane#GO:0016020;cytosol#GO:0005829;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 transfer/carrier protein#PC00219 HUMAN|HGNC=25911|UniProtKB=Q96C01 Q96C01 TIMCC PTHR21096:SF0 PROTEIN FAM136A TIM DOUBLE TWIN CX3C MOTIF PROTEIN cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=12629|UniProtKB=P35125 P35125 USP6 PTHR21646:SF96 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 6 hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein peptidase activity#GO:0019783;peptidase activity#GO:0008233;cysteine-type peptidase activity#GO:0008234;cysteine-type deubiquitinase activity#GO:0004843;catalytic activity#GO:0003824 regulation of biological quality#GO:0065008;positive regulation of TOR signaling#GO:0032008;positive regulation of signaling#GO:0023056;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;regulation of cell communication#GO:0010646;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;regulation of TORC1 signaling#GO:1903432;regulation of response to stimulus#GO:0048583;positive regulation of intracellular signal transduction#GO:1902533;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;regulation of TOR signaling#GO:0032006;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of protein stability#GO:0031647;positive regulation of TORC1 signaling#GO:1904263 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 cysteine protease#PC00081 HUMAN|HGNC=24035|UniProtKB=Q9UKG1 Q9UKG1 APPL1 PTHR46415:SF3 ADAPTOR PROTEIN, PHOSPHOTYROSINE INTERACTION, PH DOMAIN AND LEUCINE ZIPPER-CONTAINING 2 DCC-INTERACTING PROTEIN 13-ALPHA enzyme binding#GO:0019899;protein kinase binding#GO:0019901;kinase binding#GO:0019900;binding#GO:0005488;protein binding#GO:0005515 signaling#GO:0023052;cellular response to peptide hormone stimulus#GO:0071375;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;cellular response to hormone stimulus#GO:0032870;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to insulin#GO:0032868;response to endogenous stimulus#GO:0009719;response to nitrogen compound#GO:1901698;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;insulin receptor signaling pathway#GO:0008286;response to oxygen-containing compound#GO:1901700;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cellular response to chemical stimulus#GO:0070887;biological regulation#GO:0065007;response to peptide hormone#GO:0043434;response to chemical#GO:0042221;cellular response to nitrogen compound#GO:1901699;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;cellular process#GO:0009987;response to hormone#GO:0009725;cellular response to insulin stimulus#GO:0032869;cell surface receptor signaling pathway#GO:0007166 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular vesicle#GO:0097708;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endosome membrane#GO:0010008;endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;endomembrane system#GO:0012505;membrane#GO:0016020;vesicle membrane#GO:0012506;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090 scaffold/adaptor protein#PC00226 HUMAN|HGNC=19991|UniProtKB=Q8IZ08 Q8IZ08 GPR135 PTHR22752:SF3 G PROTEIN-COUPLED RECEPTOR G PROTEIN-COUPLED RECEPTOR 135 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=29099|UniProtKB=Q9Y4R8 Q9Y4R8 TELO2 PTHR15830:SF10 TELOMERE LENGTH REGULATION PROTEIN TEL2 FAMILY MEMBER TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG DNA binding#GO:0003677;protein binding#GO:0005515;Hsp90 protein binding#GO:0051879;binding#GO:0005488;nucleic acid binding#GO:0003676;telomeric repeat DNA binding#GO:0042162;sequence-specific DNA binding#GO:0043565;heat shock protein binding#GO:0031072 primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;protein folding#GO:0006457;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 HUMAN|HGNC=31106|UniProtKB=Q8TBZ8 Q8TBZ8 ZNF564 PTHR24404:SF41 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 564 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244;DNA-binding transcription factor#PC00218 HUMAN|HGNC=27905|UniProtKB=Q68DK7 Q68DK7 MSL1 PTHR21656:SF2 MALE-SPECIFIC LETHAL-1 PROTEIN MALE-SPECIFIC LETHAL 1 HOMOLOG binding#GO:0005488;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;chromatin binding#GO:0003682 cellular process#GO:0009987;cellular component organization#GO:0016043;chromatin organization#GO:0006325;chromatin remodeling#GO:0006338;cellular component organization or biogenesis#GO:0071840 intracellular anatomical structure#GO:0005622;acetyltransferase complex#GO:1902493;protein acetyltransferase complex#GO:0031248;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;chromosome#GO:0005694;intracellular protein-containing complex#GO:0140535;histone acetyltransferase complex#GO:0000123;membraneless organelle#GO:0043228;transferase complex#GO:1990234;intracellular membraneless organelle#GO:0043232;H4 histone acetyltransferase complex#GO:1902562;protein-containing complex#GO:0032991;chromatin#GO:0000785 histone modifying enzyme#PC00261;chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=6357|UniProtKB=P06870 P06870 KLK1 PTHR24271:SF47 KALLIKREIN-RELATED KALLIKREIN-1 serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175 macromolecule metabolic process#GO:0043170;system process#GO:0003008;metabolic process#GO:0008152;blood circulation#GO:0008015;protein maturation#GO:0051604;gene expression#GO:0010467;multicellular organismal process#GO:0032501;biosynthetic process#GO:0009058;biological regulation#GO:0065007;regulation of blood pressure#GO:0008217;regulation of systemic arterial blood pressure#GO:0003073;protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein metabolic process#GO:0019538;regulation of biological quality#GO:0065008;proteolysis#GO:0006508;circulatory system process#GO:0003013;primary metabolic process#GO:0044238;zymogen activation#GO:0031638 intracellular organelle#GO:0043229;extracellular region#GO:0005576;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular vesicle#GO:0097708;secretory vesicle#GO:0099503;vesicle#GO:0031982;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 serine protease#PC00203 HUMAN|HGNC=8536|UniProtKB=Q93086 Q93086 P2RX5 PTHR10125:SF12 P2X PURINOCEPTOR P2X PURINOCEPTOR 5 gated channel activity#GO:0022836;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;monoatomic cation channel activity#GO:0005261;monoatomic ion channel activity#GO:0005216;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion transmembrane transporter activity#GO:0015075 monoatomic ion transport#GO:0006811;calcium ion transport#GO:0006816;monoatomic cation transport#GO:0006812;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;transport#GO:0006810;monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987;calcium ion transmembrane transport#GO:0070588 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 ligand-gated ion channel#PC00141 HUMAN|HGNC=9051|UniProtKB=P00750 P00750 PLAT PTHR24264:SF42 TRYPSIN-RELATED TISSUE-TYPE PLASMINOGEN ACTIVATOR serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175 cell surface receptor signaling pathway#GO:0007166;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;signal transduction#GO:0007165;cellular process#GO:0009987;protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059;plasminogen activation#GO:0031639;biosynthetic process#GO:0009058;biological regulation#GO:0065007;cell migration#GO:0016477;protein maturation#GO:0051604;gene expression#GO:0010467;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;proteolysis#GO:0006508;cell communication#GO:0007154;protein metabolic process#GO:0019538;enzyme-linked receptor protein signaling pathway#GO:0007167;regulation of biological process#GO:0050789;zymogen activation#GO:0031638;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;signaling#GO:0023052;response to stimulus#GO:0050896;cell motility#GO:0048870;regulation of cellular process#GO:0050794 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease#PC00190;serine protease#PC00203 Blood coagulation#P00011>tPA#P00431;Plasminogen activating cascade#P00050>pro-tPA#P01249;Plasminogen activating cascade#P00050>tPA#P01257 HUMAN|HGNC=17940|UniProtKB=Q9P2K5 Q9P2K5 MYEF2 PTHR23003:SF15 RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN MYELIN EXPRESSION FACTOR 2 mRNA binding#GO:0003729;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 cellular component organization or biogenesis#GO:0071840;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152;gene expression#GO:0010467;RNA processing#GO:0006396;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;mRNA catabolic process#GO:0006402;cellular process#GO:0009987;RNA metabolic process#GO:0016070;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA catabolic process#GO:0006401;ribonucleoprotein complex biogenesis#GO:0022613;mRNA metabolic process#GO:0016071;negative regulation of metabolic process#GO:0009892;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;macromolecule metabolic process#GO:0043170;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;rRNA metabolic process#GO:0016072;nuclear mRNA surveillance#GO:0071028;biosynthetic process#GO:0009058;negative regulation of biosynthetic process#GO:0009890;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;nucleobase-containing compound catabolic process#GO:0034655;macromolecule biosynthetic process#GO:0009059;nucleic acid catabolic process#GO:0141188;negative regulation of macromolecule metabolic process#GO:0010605;rRNA processing#GO:0006364;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238 nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 RNA splicing factor#PC00148 HUMAN|HGNC=2154|UniProtKB=Q9H4B4 Q9H4B4 PLK3 PTHR24345:SF42 SERINE/THREONINE-PROTEIN KINASE PLK SERINE_THREONINE-PROTEIN KINASE PLK3 catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 intracellular signal transduction#GO:0035556;microtubule cytoskeleton organization#GO:0000226;cell communication#GO:0007154;regulation of cell cycle G1/S phase transition#GO:1902806;regulation of cellular process#GO:0050794;mitotic cell cycle#GO:0000278;cellular response to stimulus#GO:0051716;Golgi organization#GO:0007030;microtubule cytoskeleton organization involved in mitosis#GO:1902850;regulation of cell cycle phase transition#GO:1901987;cell cycle#GO:0007049;mitotic cell cycle checkpoint signaling#GO:0007093;mitotic cell cycle process#GO:1903047;spindle organization#GO:0007051;negative regulation of cell cycle process#GO:0010948;DNA damage response#GO:0006974;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;regulation of mitotic cell cycle#GO:0007346;negative regulation of mitotic cell cycle#GO:0045930;cellular component disassembly#GO:0022411;regulation of mitotic cell cycle phase transition#GO:1901990;organelle disassembly#GO:1903008;regulation of G1/S transition of mitotic cell cycle#GO:2000045;cellular response to stress#GO:0033554;signaling#GO:0023052;regulation of cell cycle#GO:0051726;mitotic spindle organization#GO:0007052;response to stimulus#GO:0050896;cell cycle process#GO:0022402;regulation of biological process#GO:0050789;negative regulation of cell cycle phase transition#GO:1901988;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;negative regulation of cell cycle#GO:0045786;endomembrane system organization#GO:0010256;cytoskeleton organization#GO:0007010;regulation of cell cycle process#GO:0010564;cell cycle checkpoint signaling#GO:0000075;negative regulation of mitotic cell cycle phase transition#GO:1901991;cellular process#GO:0009987;signal transduction#GO:0007165;response to stress#GO:0006950;organelle organization#GO:0006996 membraneless organelle#GO:0043228;chromosome, centromeric region#GO:0000775;cytoskeleton#GO:0005856;condensed chromosome#GO:0000793;spindle#GO:0005819;centrosome#GO:0005813;microtubule organizing center#GO:0005815;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;condensed chromosome, centromeric region#GO:0000779;microtubule cytoskeleton#GO:0015630;nucleus#GO:0005634;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;chromosome#GO:0005694;spindle pole#GO:0000922;kinetochore#GO:0000776 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=18061|UniProtKB=Q9BY08 Q9BY08 EBPL PTHR14207:SF4 STEROL ISOMERASE EMOPAMIL-BINDING PROTEIN-LIKE catalytic activity#GO:0003824;isomerase activity#GO:0016853;intramolecular oxidoreductase activity#GO:0016860 lipid biosynthetic process#GO:0008610;biosynthetic process#GO:0009058;steroid metabolic process#GO:0008202;sterol biosynthetic process#GO:0016126;primary metabolic process#GO:0044238;cellular process#GO:0009987;steroid biosynthetic process#GO:0006694;sterol metabolic process#GO:0016125;metabolic process#GO:0008152;lipid metabolic process#GO:0006629 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 isomerase#PC00135 HUMAN|HGNC=16372|UniProtKB=Q9UBU6 Q9UBU6 FAM8A1 PTHR13659:SF5 AUTOSOMAL HIGHLY CONSERVED PROTEIN PROTEIN FAM8A1 HUMAN|HGNC=29899|UniProtKB=Q96QD5 Q96QD5 DEPDC7 PTHR16206:SF9 DEP DOMAIN-CONTAINING DEP DOMAIN-CONTAINING PROTEIN 7 scaffold/adaptor protein#PC00226 HUMAN|HGNC=598|UniProtKB=Q06481 Q06481 APLP2 PTHR23103:SF14 ALZHEIMER'S DISEASE BETA-AMYLOID RELATED AMYLOID BETA PRECURSOR LIKE PROTEIN 2 multicellular organismal process#GO:0032501;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;cell morphogenesis involved in neuron differentiation#GO:0048667;axon development#GO:0061564;neuron projection development#GO:0031175;cellular process#GO:0009987;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;neurogenesis#GO:0022008;cell projection morphogenesis#GO:0048858;neuron projection morphogenesis#GO:0048812;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron differentiation#GO:0030182;developmental process#GO:0032502;cell morphogenesis#GO:0000902;central nervous system development#GO:0007417;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell development#GO:0048468;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;axonogenesis#GO:0007409;neuron development#GO:0048666;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699 protease inhibitor#PC00191 HUMAN|HGNC=28116|UniProtKB=Q5TA50 Q5TA50 CPTP PTHR10219:SF20 GLYCOLIPID TRANSFER PROTEIN-RELATED CERAMIDE-1-PHOSPHATE TRANSFER PROTEIN phospholipid transfer activity#GO:0120014;lipid transfer activity#GO:0120013;lipid binding#GO:0008289;binding#GO:0005488;small molecule binding#GO:0036094;anion binding#GO:0043168;lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104;ion binding#GO:0043167;phospholipid binding#GO:0005543;transporter activity#GO:0005215 ceramide transport#GO:0035627;membrane organization#GO:0061024;lipid transport#GO:0006869;cellular process#GO:0009987;cellular component organization#GO:0016043;nitrogen compound transport#GO:0071705;macromolecule localization#GO:0033036;intermembrane lipid transfer#GO:0120009;establishment of localization#GO:0051234;localization#GO:0051179;cellular component organization or biogenesis#GO:0071840;transport#GO:0006810;lipid localization#GO:0010876 membrane#GO:0016020;cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 transfer/carrier protein#PC00219 HUMAN|HGNC=29467|UniProtKB=Q5T754 Q5T754 LCE1F PTHR48615:SF2 LATE CORNIFIED ENVELOPE PROTEIN 1C LATE CORNIFIED ENVELOPE PROTEIN 1F HUMAN|HGNC=7428|UniProtKB=Q14872 Q14872 MTF1 PTHR19818:SF131 ZINC FINGER PROTEIN ZIC AND GLI METAL REGULATORY TRANSCRIPTION FACTOR 1 DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=9602|UniProtKB=P43119 P43119 PTGIR PTHR11866:SF7 G-PROTEIN COUPLED RECEPTOR FAMILY 1 MEMBER PROSTACYCLIN RECEPTOR G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of biological quality#GO:0065008;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;G protein-coupled receptor signaling pathway#GO:0007186;positive regulation of cytosolic calcium ion concentration#GO:0007204;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;negative regulation of cell population proliferation#GO:0008285;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;negative regulation of cellular process#GO:0048523;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 Gonadotropin-releasing hormone receptor pathway#P06664>PG Rcs#P06836 HUMAN|HGNC=10452|UniProtKB=P31350 P31350 RRM2 PTHR23409:SF20 RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2 biosynthetic process#GO:0009058;cellular process#GO:0009987;metabolic process#GO:0008152 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cytosol#GO:0005829 oxidoreductase#PC00176;reductase#PC00198;metabolite interconversion enzyme#PC00262 De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>UDP reductase#P02921;De novo purine biosynthesis#P02738>GDP reductase#P02909;p53 pathway#P00059>R2#G04692;De novo purine biosynthesis#P02738>ADP reductase#P02902;De novo pyrimidine deoxyribonucleotide biosynthesis#P02739>CDP Reductase#P02915 HUMAN|HGNC=6740|UniProtKB=P61626 P61626 LYZ PTHR11407:SF28 LYSOZYME C LYSOZYME C peptidoglycan muralytic activity#GO:0061783;catalytic activity#GO:0003824;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;hydrolase activity, acting on glycosyl bonds#GO:0016798;hydrolase activity#GO:0016787;lysozyme activity#GO:0003796 response to bacterium#GO:0009617;defense response to bacterium#GO:0042742;defense response#GO:0006952;response to external stimulus#GO:0009605;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;defense response to Gram-positive bacterium#GO:0050830;response to stimulus#GO:0050896;response to other organism#GO:0051707;defense response to Gram-negative bacterium#GO:0050829;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 glycosidase#PC00110 HUMAN|HGNC=25357|UniProtKB=Q8N1N0 Q8N1N0 CLEC4F PTHR22802:SF238 C-TYPE LECTIN SUPERFAMILY MEMBER C-TYPE LECTIN DOMAIN FAMILY 4 MEMBER F binding#GO:0005488;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;pattern recognition receptor activity#GO:0038187;carbohydrate binding#GO:0030246 immune response#GO:0006955;immune system process#GO:0002376;response to stimulus#GO:0050896 cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897 membrane traffic protein#PC00150 HUMAN|HGNC=4196|UniProtKB=Q14397 Q14397 GCKR PTHR10088:SF4 GLUCOKINASE REGULATORY PROTEIN GLUCOKINASE REGULATORY PROTEIN enzyme inhibitor activity#GO:0004857;carbohydrate derivative binding#GO:0097367;molecular sensor activity#GO:0140299;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;kinase inhibitor activity#GO:0019210;anion binding#GO:0043168;small molecule binding#GO:0036094;binding#GO:0005488;ion binding#GO:0043167;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234 cellular homeostasis#GO:0019725;intracellular protein localization#GO:0008104;intracellular chemical homeostasis#GO:0055082;glucose homeostasis#GO:0042593;intracellular glucose homeostasis#GO:0001678;localization#GO:0051179;chemical homeostasis#GO:0048878;homeostatic process#GO:0042592;protein localization to organelle#GO:0033365;carbohydrate homeostasis#GO:0033500;protein localization to nucleus#GO:0034504;macromolecule localization#GO:0033036 membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 protein-binding activity modulator#PC00095 HUMAN|HGNC=24453|UniProtKB=Q9BVC3 Q9BVC3 DSCC1 PTHR13395:SF6 SISTER CHROMATID COHESION PROTEIN DCC1-RELATED SISTER CHROMATID COHESION PROTEIN DCC1 mitotic sister chromatid cohesion#GO:0007064;cell cycle#GO:0007049;organelle organization#GO:0006996;cellular component organization#GO:0016043;cellular process#GO:0009987;cell cycle process#GO:0022402;cellular component organization or biogenesis#GO:0071840;sister chromatid cohesion#GO:0007062;chromosome organization#GO:0051276 chromosome, centromeric region#GO:0000775;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;chromosomal region#GO:0098687;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;chromosome#GO:0005694;chromatin#GO:0000785;nucleus#GO:0005634;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232 replication origin binding protein#PC00199;DNA metabolism protein#PC00009 HUMAN|HGNC=19863|UniProtKB=Q8IZM9 Q8IZM9 SLC38A6 PTHR22950:SF366 AMINO ACID TRANSPORTER SOLUTE CARRIER FAMILY 38 MEMBER 6 L-amino acid transmembrane transporter activity#GO:0015179;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;transporter activity#GO:0005215;neutral L-amino acid transmembrane transporter activity#GO:0015175;amino acid transmembrane transporter activity#GO:0015171 amino acid transport#GO:0006865;organic acid transport#GO:0015849;transport#GO:0006810;carboxylic acid transport#GO:0046942;localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;amino acid transmembrane transport#GO:0003333;neutral amino acid transport#GO:0015804;L-amino acid transport#GO:0015807;nitrogen compound transport#GO:0071705;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 amino acid transporter#PC00046;secondary carrier transporter#PC00258 HUMAN|HGNC=32281|UniProtKB=Q6ZN79 Q6ZN79 ZNF705A PTHR24381:SF303 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 705A-RELATED sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=3582|UniProtKB=O15360 O15360 FANCA PTHR12047:SF2 FANCONI ANEMIA GROUP A PROTEIN FANCONI ANEMIA GROUP A PROTEIN regulation of cell differentiation#GO:0045595;regulation of hemopoiesis#GO:1903706;regulation of biological process#GO:0050789;regulation of multicellular organismal development#GO:2000026;regulation of cell activation#GO:0050865;regulation of cell development#GO:0060284;regulation of leukocyte activation#GO:0002694;regulation of developmental process#GO:0050793;biological regulation#GO:0065007;regulation of multicellular organismal process#GO:0051239;regulation of lymphocyte activation#GO:0051249;regulation of immune system process#GO:0002682;regulation of T cell activation#GO:0050863;regulation of cellular process#GO:0050794 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;Fanconi anaemia nuclear complex#GO:0043240;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513 HUMAN|HGNC=4476|UniProtKB=Q99679 Q99679 GPR21 PTHR24249:SF384 HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR G PROTEIN-COUPLED RECEPTOR 21-RELATED molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021 HUMAN|HGNC=25633|UniProtKB=Q7Z5S9 Q7Z5S9 TMEM144 PTHR16119:SF17 TRANSMEMBRANE PROTEIN 144 TRANSMEMBRANE PROTEIN 144 HUMAN|HGNC=18684|UniProtKB=Q9Y6V7 Q9Y6V7 DDX49 PTHR24031:SF761 RNA HELICASE ATP-DEPENDENT RNA HELICASE DDX49-RELATED ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058 nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 RNA metabolism protein#PC00031;RNA helicase#PC00032 HUMAN|HGNC=26841|UniProtKB=Q3SX64 Q3SX64 CIMAP1D PTHR21580:SF62 SHIPPO-1-RELATED PROTEIN CIMAP1D male gamete generation#GO:0048232;cellular process#GO:0009987;cellular developmental process#GO:0048869;developmental process#GO:0032502;spermatogenesis#GO:0007283;gamete generation#GO:0007276;cell differentiation#GO:0030154;cellular process involved in reproduction in multicellular organism#GO:0022412;reproductive process#GO:0022414;cell development#GO:0048468;developmental process involved in reproduction#GO:0003006;germ cell development#GO:0007281;anatomical structure development#GO:0048856;multicellular organismal reproductive process#GO:0048609;spermatid differentiation#GO:0048515;spermatid development#GO:0007286;sexual reproduction#GO:0019953 cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;organelle#GO:0043226;supramolecular complex#GO:0099080;cytoplasmic microtubule#GO:0005881;microtubule cytoskeleton#GO:0015630;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;microtubule#GO:0005874;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 structural protein#PC00211 HUMAN|HGNC=2350|UniProtKB=O60519 O60519 CREBL2 PTHR21051:SF4 CAMP-RESPONSIVE ELEMENT-BINDING PROTEIN-LIKE 2 CAMP-RESPONSIVE ELEMENT-BINDING PROTEIN-LIKE 2 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=14203|UniProtKB=Q8WXH2 Q8WXH2 JPH3 PTHR23085:SF7 GH28348P JUNCTOPHILIN-3 regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of trans-synaptic signaling#GO:0099177;modulation of chemical synaptic transmission#GO:0050804;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;regulation of synaptic plasticity#GO:0048167;regulation of signaling#GO:0023051;regulation of biological quality#GO:0065008 organelle membrane#GO:0031090;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;cytoplasm#GO:0005737;plasma membrane#GO:0005886;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cell periphery#GO:0071944;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;sarcoplasm#GO:0016528;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175 HUMAN|HGNC=28110|UniProtKB=Q8WVY7 Q8WVY7 UBLCP1 PTHR48493:SF1 UBIQUITIN-LIKE DOMAIN-CONTAINING CTD PHOSPHATASE 1 UBIQUITIN-LIKE DOMAIN-CONTAINING CTD PHOSPHATASE 1 hydrolase activity#GO:0016787;protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578 regulation of biological process#GO:0050789;regulation of protein-containing complex assembly#GO:0043254;biological regulation#GO:0065007;regulation of cellular component biogenesis#GO:0044087;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=4853|UniProtKB=Q92769 Q92769 HDAC2 PTHR10625:SF3 HISTONE DEACETYLASE HDAC1-RELATED HISTONE DEACETYLASE 2 histone modifying activity#GO:0140993;catalytic activity, acting on a protein#GO:0140096;deacetylase activity#GO:0019213;catalytic activity#GO:0003824;deacylase activity#GO:0160215;histone deacetylase activity#GO:0004407 negative regulation of cellular process#GO:0048523;negative regulation of gene expression, epigenetic#GO:0045814;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468;epigenetic regulation of gene expression#GO:0040029;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;cellular component assembly#GO:0022607;heterochromatin organization#GO:0070828;biological regulation#GO:0065007;chromatin organization#GO:0006325;negative regulation of biosynthetic process#GO:0009890;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;heterochromatin formation#GO:0031507;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;chromatin remodeling#GO:0006338;negative regulation of metabolic process#GO:0009892 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ATPase complex#GO:1904949;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;SWI/SNF superfamily-type complex#GO:0070603;chromosome#GO:0005694;organelle lumen#GO:0043233;transcription regulator complex#GO:0005667;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;chromatin#GO:0000785;histone deacetylase complex#GO:0000118;membrane-enclosed lumen#GO:0031974 Wnt signaling pathway#P00057>Histone deacetylase#P01472;p53 pathway#P00059>HDAC1#P04612 HUMAN|HGNC=14222|UniProtKB=Q9NQ69 Q9NQ69 LHX9 PTHR24208:SF95 LIM/HOMEOBOX PROTEIN LHX LIM_HOMEOBOX PROTEIN LHX9 double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of gene expression#GO:0010468;neurogenesis#GO:0022008;multicellular organism development#GO:0007275;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;developmental process#GO:0032502;neuron differentiation#GO:0030182;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;nervous system development#GO:0007399;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA-binding transcription factor#PC00218;homeodomain transcription factor#PC00119 HUMAN|HGNC=4195|UniProtKB=P35557 P35557 GCK PTHR19443:SF3 HEXOKINASE HEXOKINASE-4 phosphotransferase activity, alcohol group as acceptor#GO:0016773;hexokinase activity#GO:0004396;catalytic activity#GO:0003824;transferase activity#GO:0016740;carbohydrate kinase activity#GO:0019200;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 cellular homeostasis#GO:0019725;ADP metabolic process#GO:0046031;generation of precursor metabolites and energy#GO:0006091;purine ribonucleoside diphosphate metabolic process#GO:0009179;biological regulation#GO:0065007;glycolytic process#GO:0006096;purine ribonucleoside triphosphate metabolic process#GO:0009205;organophosphate metabolic process#GO:0019637;purine ribonucleoside diphosphate catabolic process#GO:0009181;aerobic respiration#GO:0009060;pyridine-containing compound metabolic process#GO:0072524;nucleoside diphosphate metabolic process#GO:0009132;regulation of cell communication#GO:0010646;nucleoside triphosphate metabolic process#GO:0009141;carbohydrate derivative catabolic process#GO:1901136;nucleoside phosphate catabolic process#GO:1901292;regulation of cellular process#GO:0050794;regulation of protein secretion#GO:0050708;purine nucleoside triphosphate metabolic process#GO:0009144;primary metabolic process#GO:0044238;hexose metabolic process#GO:0019318;nucleobase-containing small molecule metabolic process#GO:0055086;glucose homeostasis#GO:0042593;purine nucleoside diphosphate catabolic process#GO:0009137;ADP catabolic process#GO:0046032;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;regulation of insulin secretion#GO:0050796;regulation of biological quality#GO:0065008;regulation of hormone secretion#GO:0046883;nucleotide metabolic process#GO:0009117;carbohydrate catabolic process#GO:0016052;regulation of signaling#GO:0023051;purine nucleoside diphosphate metabolic process#GO:0009135;ribonucleotide metabolic process#GO:0009259;pyruvate metabolic process#GO:0006090;purine nucleotide metabolic process#GO:0006163;regulation of biological process#GO:0050789;purine-containing compound metabolic process#GO:0072521;pyridine-containing compound catabolic process#GO:0072526;monocarboxylic acid metabolic process#GO:0032787;intracellular chemical homeostasis#GO:0055082;energy derivation by oxidation of organic compounds#GO:0015980;nucleotide catabolic process#GO:0009166;nucleobase-containing compound metabolic process#GO:0006139;carbohydrate derivative metabolic process#GO:1901135;ribonucleotide catabolic process#GO:0009261;nucleobase-containing compound catabolic process#GO:0034655;regulation of establishment of protein localization#GO:0070201;ribonucleoside diphosphate catabolic process#GO:0009191;regulation of secretion#GO:0051046;organophosphate catabolic process#GO:0046434;cellular respiration#GO:0045333;purine nucleotide catabolic process#GO:0006195;homeostatic process#GO:0042592;carbohydrate metabolic process#GO:0005975;nucleoside phosphate metabolic process#GO:0006753;catabolic process#GO:0009056;glucose 6-phosphate metabolic process#GO:0051156;purine ribonucleotide catabolic process#GO:0009154;nucleoside diphosphate catabolic process#GO:0009134;regulation of transport#GO:0051049;regulation of localization#GO:0032879;purine-containing compound catabolic process#GO:0072523;glucose metabolic process#GO:0006006;chemical homeostasis#GO:0048878;metabolic process#GO:0008152;monosaccharide metabolic process#GO:0005996;purine ribonucleotide metabolic process#GO:0009150;nicotinamide nucleotide metabolic process#GO:0046496;ATP metabolic process#GO:0046034;intracellular glucose homeostasis#GO:0001678;regulation of protein localization#GO:0032880;regulation of secretion by cell#GO:1903530;oxoacid metabolic process#GO:0043436;pyridine nucleotide catabolic process#GO:0019364;small molecule metabolic process#GO:0044281;regulation of protein transport#GO:0051223;ribonucleoside diphosphate metabolic process#GO:0009185;carbohydrate homeostasis#GO:0033500;regulation of hormone levels#GO:0010817;carboxylic acid metabolic process#GO:0019752;phosphorus metabolic process#GO:0006793 mitochondrion#GO:0005739;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;outer membrane#GO:0019867;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;side of membrane#GO:0098552;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;membrane#GO:0016020;cytosol#GO:0005829;cytoplasm#GO:0005737;organelle outer membrane#GO:0031968;cytoplasmic side of membrane#GO:0098562;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;mitochondrial outer membrane#GO:0005741 metabolite interconversion enzyme#PC00262;kinase#PC00137;transferase#PC00220 HUMAN|HGNC=3541|UniProtKB=P13726 P13726 F3 PTHR20859:SF22 INTERFERON/INTERLEUKIN RECEPTOR TISSUE FACTOR signaling receptor activity#GO:0038023;immune receptor activity#GO:0140375;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888;cytokine receptor activity#GO:0004896 signal transduction#GO:0007165;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;response to cytokine#GO:0034097;response to chemical#GO:0042221;regulation of cellular process#GO:0050794;cell surface receptor signaling pathway#GO:0007166;cytokine-mediated signaling pathway#GO:0019221;response to peptide#GO:1901652;cell communication#GO:0007154 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 Blood coagulation#P00011>Tissue Factor#P00450;Angiogenesis#P00005>TF#P00191 HUMAN|HGNC=18314|UniProtKB=Q92730 Q92730 RND1 PTHR24072:SF23 RHO FAMILY GTPASE RHO-RELATED GTP-BINDING PROTEIN RHO6 ribonucleotide binding#GO:0032553;hydrolase activity, acting on acid anhydrides#GO:0016817;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;carbohydrate derivative binding#GO:0097367;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;enzyme binding#GO:0019899;guanyl nucleotide binding#GO:0019001;protein kinase binding#GO:0019901;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;kinase binding#GO:0019900;nucleoside phosphate binding#GO:1901265;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;protein binding#GO:0005515;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleotide binding#GO:0000166;anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167;GTPase activity#GO:0003924;hydrolase activity#GO:0016787 supramolecular fiber organization#GO:0097435;cell communication#GO:0007154;actin filament-based process#GO:0030029;signaling#GO:0023052;regulation of cytoskeleton organization#GO:0051493;response to stimulus#GO:0050896;regulation of cellular component organization#GO:0051128;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;regulation of organelle organization#GO:0033043;cellular component organization#GO:0016043;actin filament organization#GO:0007015;cellular component organization or biogenesis#GO:0071840;regulation of actin filament-based process#GO:0032970;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;regulation of actin cytoskeleton organization#GO:0032956;signal transduction#GO:0007165;cellular process#GO:0009987;organelle organization#GO:0006996 cell periphery#GO:0071944;membrane#GO:0016020;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 small GTPase#PC00208;G-protein#PC00020 Integrin signalling pathway#P00034>Rho#P00948 HUMAN|HGNC=26948|UniProtKB=Q5T013 Q5T013 HYI PTHR43489:SF6 ISOMERASE HYDROXYPYRUVATE ISOMERASE-RELATED intramolecular oxidoreductase activity, interconverting aldoses and ketoses#GO:0016861;catalytic activity#GO:0003824;isomerase activity#GO:0016853;intramolecular oxidoreductase activity#GO:0016860 aldehyde metabolic process#GO:0006081;cellular process#GO:0009987;monocarboxylic acid metabolic process#GO:0032787;carboxylic acid metabolic process#GO:0019752;small molecule metabolic process#GO:0044281;glyoxylate metabolic process#GO:0046487;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152 isomerase#PC00135;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=25925|UniProtKB=Q96K30 Q96K30 RITA1 PTHR34917:SF1 RBPJ-INTERACTING AND TUBULIN-ASSOCIATED PROTEIN 1 RBPJ-INTERACTING AND TUBULIN-ASSOCIATED PROTEIN 1 binding#GO:0005488;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;protein binding#GO:0005515 negative regulation of Notch signaling pathway#GO:0045746;regulation of response to stimulus#GO:0048583;transport#GO:0006810;intracellular transport#GO:0046907;negative regulation of cellular process#GO:0048523;establishment of localization#GO:0051234;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of signal transduction#GO:0009968;negative regulation of response to stimulus#GO:0048585;regulation of signaling#GO:0023051;nucleocytoplasmic transport#GO:0006913;regulation of Notch signaling pathway#GO:0008593;negative regulation of signaling#GO:0023057;nuclear transport#GO:0051169;negative regulation of cell communication#GO:0010648;nuclear export#GO:0051168;localization#GO:0051179;cellular localization#GO:0051641;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=10735|UniProtKB=Q9NTN9 Q9NTN9 SEMA4G PTHR11036:SF17 SEMAPHORIN SEMAPHORIN-4G receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515;molecular function activator activity#GO:0140677 cellular response to stimulus#GO:0051716;locomotion#GO:0040011;regulation of cellular process#GO:0050794;chemotaxis#GO:0006935;system development#GO:0048731;anatomical structure development#GO:0048856;regulation of cell motility#GO:2000145;cell communication#GO:0007154;positive regulation of cell migration#GO:0030335;positive regulation of cellular process#GO:0048522;axon guidance#GO:0007411;axon development#GO:0061564;plasma membrane bounded cell projection organization#GO:0120036;regulation of locomotion#GO:0040012;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;neuron projection morphogenesis#GO:0048812;regulation of cell migration#GO:0030334;developmental process#GO:0032502;neurogenesis#GO:0022008;positive regulation of locomotion#GO:0040017;response to external stimulus#GO:0009605;neuron projection guidance#GO:0097485;cellular developmental process#GO:0048869;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;positive regulation of cell motility#GO:2000147;cell development#GO:0048468;signaling#GO:0023052;cell morphogenesis#GO:0000902;response to stimulus#GO:0050896;cell projection organization#GO:0030030;cell differentiation#GO:0030154;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;axonogenesis#GO:0007409;neuron development#GO:0048666;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;neuron projection development#GO:0031175;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;taxis#GO:0042330;response to chemical#GO:0042221;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell surface receptor signaling pathway#GO:0007166;neuron differentiation#GO:0030182;cell projection morphogenesis#GO:0048858;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 membrane-bound signaling molecule#PC00152 HUMAN|HGNC=18026|UniProtKB=Q9BYX2 Q9BYX2 TBC1D2 PTHR22957:SF570 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN TBC1 DOMAIN FAMILY MEMBER 2A molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme activator activity#GO:0008047 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 GTPase-activating protein#PC00257;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HUMAN|HGNC=20261|UniProtKB=Q9BVL2 Q9BVL2 NUP58 PTHR13437:SF2 NUCLEOPORIN P58/P45 NUCLEOPORIN-LIKE PROTEIN 1 NUCLEOPORIN P58_P45 structural molecule activity#GO:0005198;structural constituent of nuclear pore#GO:0017056 nucleocytoplasmic transport#GO:0006913;transport#GO:0006810;intracellular transport#GO:0046907;nuclear transport#GO:0051169;cellular localization#GO:0051641;establishment of localization#GO:0051234;localization#GO:0051179;cellular process#GO:0009987;establishment of localization in cell#GO:0051649 nuclear pore#GO:0005643;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;organelle#GO:0043226;nucleus#GO:0005634;organelle envelope#GO:0031967 transporter#PC00227 HUMAN|HGNC=14708|UniProtKB=Q9Y5P0 Q9Y5P0 OR51B4 PTHR26450:SF154 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 51B4 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=2494|UniProtKB=Q13363 Q13363 CTBP1 PTHR46029:SF2 C-TERMINAL-BINDING PROTEIN C-TERMINAL-BINDING PROTEIN 1 transcription factor binding#GO:0008134;transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712;transcription coactivator activity#GO:0003713;transcription regulator activity#GO:0140110;binding#GO:0005488;DNA-binding transcription factor binding#GO:0140297;protein binding#GO:0005515 regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 transcription cofactor#PC00217 Wnt signaling pathway#P00057>C-terminal Binding Protein#P01439 HUMAN|HGNC=7973|UniProtKB=Q9Y466 Q9Y466 NR2E1 PTHR24083:SF98 NUCLEAR HORMONE RECEPTOR NUCLEAR RECEPTOR SUBFAMILY 2 GROUP E MEMBER 1 transcription regulatory region nucleic acid binding#GO:0001067;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110;sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023;cis-regulatory region sequence-specific DNA binding#GO:0000987;molecular transducer activity#GO:0060089;DNA binding#GO:0003677;nuclear receptor activity#GO:0004879;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;cellular process#GO:0009987;negative regulation of macromolecule metabolic process#GO:0010605;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 C4 zinc finger nuclear receptor#PC00169;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=30631|UniProtKB=Q96BN2 Q96BN2 TADA1 PTHR21277:SF5 TRANSCRIPTIONAL ADAPTER 1 TRANSCRIPTIONAL ADAPTER 1 structural molecule activity#GO:0005198;protein complex scaffold activity#GO:0140378 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 transferase complex#GO:1990234;histone acetyltransferase complex#GO:0000123;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;chromatin#GO:0000785;SAGA complex#GO:0000124;peptidase complex#GO:1905368;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;protein acetyltransferase complex#GO:0031248;acetyltransferase complex#GO:1902493;intracellular anatomical structure#GO:0005622;SAGA-type complex#GO:0070461;chromosome#GO:0005694;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=29084|UniProtKB=O75123 O75123 ZNF623 PTHR24377:SF244 IP01015P-RELATED ZINC FINGER PROTEIN 623 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=6404|UniProtKB=Q9Y664 Q9Y664 KPTN PTHR15435:SF2 KICSTOR COMPLEX PROTEIN KAPTIN KICSTOR COMPLEX PROTEIN KAPTIN protein binding#GO:0005515;protein-containing complex binding#GO:0044877;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;actin binding#GO:0003779;actin filament binding#GO:0051015 response to starvation#GO:0042594;negative regulation of biological process#GO:0048519;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;negative regulation of TOR signaling#GO:0032007;regulation of cell communication#GO:0010646;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;cellular response to stress#GO:0033554;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;response to stress#GO:0006950;response to nutrient levels#GO:0031667;cellular process#GO:0009987;regulation of TOR signaling#GO:0032006;negative regulation of response to stimulus#GO:0048585;cellular response to amino acid starvation#GO:0034198;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;cellular response to starvation#GO:0009267;regulation of response to stimulus#GO:0048583;negative regulation of TORC1 signaling#GO:1904262;cellular response to nutrient levels#GO:0031669;regulation of TORC1 signaling#GO:1903432 cell leading edge#GO:0031252;lamellipodium#GO:0030027;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025 HUMAN|HGNC=20799|UniProtKB=Q76EJ3 Q76EJ3 SLC35D2 PTHR11132:SF262 SOLUTE CARRIER FAMILY 35 NUCLEOTIDE SUGAR TRANSPORTER SLC35D2 antiporter activity#GO:0015297;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;active transmembrane transporter activity#GO:0022804;carboxylic acid transmembrane transporter activity#GO:0046943;organophosphate ester transmembrane transporter activity#GO:0015605;nucleobase-containing compound transmembrane transporter activity#GO:0015932;carbohydrate derivative transmembrane transporter activity#GO:1901505;nucleotide-sugar transmembrane transporter activity#GO:0005338 transmembrane transport#GO:0055085;establishment of localization#GO:0051234;localization#GO:0051179;transport#GO:0006810;organophosphate ester transport#GO:0015748;nucleobase-containing compound transport#GO:0015931;nitrogen compound transport#GO:0071705;carbohydrate derivative transport#GO:1901264;cellular process#GO:0009987;nucleotide-sugar transmembrane transport#GO:0015780 bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;Golgi membrane#GO:0000139;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;membrane#GO:0016020 secondary carrier transporter#PC00258;transporter#PC00227 HUMAN|HGNC=11275|UniProtKB=Q01082 Q01082 SPTBN1 PTHR11915:SF226 SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN SPECTRIN BETA CHAIN, NON-ERYTHROCYTIC 1 actin binding#GO:0003779;actin filament binding#GO:0051015;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 cellular process#GO:0009987;macromolecule localization#GO:0033036;protein localization to membrane#GO:0072657;organelle organization#GO:0006996;cellular component organization#GO:0016043;protein localization to plasma membrane#GO:0072659;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;localization within membrane#GO:0051668;actin filament-based process#GO:0030029;protein localization to cell periphery#GO:1990778;intracellular protein localization#GO:0008104;cellular component organization or biogenesis#GO:0071840;localization#GO:0051179;cellular localization#GO:0051641 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;actin cytoskeleton#GO:0015629;cortical cytoskeleton#GO:0030863;cell cortex#GO:0005938;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;cytoskeleton#GO:0005856;cell junction#GO:0030054;membraneless organelle#GO:0043228;membrane#GO:0016020;cell periphery#GO:0071944;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;cortical actin cytoskeleton#GO:0030864;cytoplasm#GO:0005737 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=1944|UniProtKB=P52757 P52757 CHN2 PTHR46075:SF4 CHIMERIN FAMILY MEMBER BETA-CHIMAERIN enzyme activator activity#GO:0008047;enzyme regulator activity#GO:0030234;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 male gamete generation#GO:0048232;cellular component assembly#GO:0022607;endomembrane system organization#GO:0010256;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;anatomical structure formation involved in morphogenesis#GO:0048646;vesicle organization#GO:0016050;cellular anatomical entity morphogenesis#GO:0032989;developmental process#GO:0032502;spermatogenesis#GO:0007283;gamete generation#GO:0007276;cell differentiation#GO:0030154;reproductive process#GO:0022414;cell development#GO:0048468;cellular process involved in reproduction in multicellular organism#GO:0022412;developmental process involved in reproduction#GO:0003006;cellular component organization#GO:0016043;germ cell development#GO:0007281;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;multicellular organismal reproductive process#GO:0048609;spermatid differentiation#GO:0048515;cellular component assembly involved in morphogenesis#GO:0010927;organelle assembly#GO:0070925;acrosome assembly#GO:0001675;spermatid development#GO:0007286;sexual reproduction#GO:0019953 HUMAN|HGNC=31290|UniProtKB=A6NET4 A6NET4 OR5K3 PTHR26452:SF247 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 5K3 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 system process#GO:0003008;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;sensory perception#GO:0007600;nervous system process#GO:0050877;sensory perception of chemical stimulus#GO:0007606 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=4241|UniProtKB=Q06210 Q06210 GFPT1 PTHR10937:SF12 GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING GLUTAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE [ISOMERIZING] 1 transaminase activity#GO:0008483;catalytic activity#GO:0003824;transferase activity#GO:0016740 organophosphate biosynthetic process#GO:0090407;UDP-N-acetylglucosamine metabolic process#GO:0006047;UDP-N-acetylglucosamine biosynthetic process#GO:0006048;amino sugar metabolic process#GO:0006040;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;carbohydrate derivative biosynthetic process#GO:1901137;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing small molecule metabolic process#GO:0055086;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;nucleotide-sugar metabolic process#GO:0009225;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135 transaminase#PC00216 O-antigen biosynthesis#P02757>Fructose-6-phosphate aminotransferase#P03051;N-acetylglucosamine metabolism#P02756>Fructose-6-phosphate aminotransferase#P03042 HUMAN|HGNC=18997|UniProtKB=Q96QS6 Q96QS6 PSKH2 PTHR24347:SF255 SERINE/THREONINE-PROTEIN KINASE SERINE_THREONINE-PROTEIN KINASE H2 protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=8143|UniProtKB=Q14982 Q14982 OPCML PTHR42757:SF17 IGLON FAMILY OF IMMUNOGLOBULIN SUPERFAMILY-RELATED OPIOID-BINDING PROTEIN_CELL ADHESION MOLECULE regulation of synapse structure or activity#GO:0050803;regulation of biological quality#GO:0065008;cell adhesion#GO:0007155;regulation of synapse organization#GO:0050807;regulation of cell junction assembly#GO:1901888;regulation of cellular component organization#GO:0051128;regulation of synapse assembly#GO:0051963;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of cellular component biogenesis#GO:0044087;cell-cell adhesion#GO:0098609;regulation of biological process#GO:0050789;heterophilic cell-cell adhesion#GO:0007157;cellular process#GO:0009987 cell junction#GO:0030054;postsynaptic density#GO:0014069;plasma membrane#GO:0005886;synapse#GO:0045202;cellular anatomical structure#GO:0110165;neuron to neuron synapse#GO:0098984;postsynaptic specialization#GO:0099572;organelle#GO:0043226;asymmetric synapse#GO:0032279;cell periphery#GO:0071944;postsynapse#GO:0098794;membrane#GO:0016020 immunoglobulin#PC00123 HUMAN|HGNC=14621|UniProtKB=Q9BZD4 Q9BZD4 NUF2 PTHR21650:SF2 MEMBRALIN/KINETOCHORE PROTEIN NUF2 KINETOCHORE PROTEIN NUF2 binding#GO:0005488;protein-containing complex binding#GO:0044877 mitotic sister chromatid segregation#GO:0000070;meiotic nuclear division#GO:0140013;spindle organization#GO:0007051;chromosome organization#GO:0051276;meiotic chromosome segregation#GO:0045132;mitotic cell cycle process#GO:1903047;microtubule cytoskeleton organization involved in mitosis#GO:1902850;cell cycle#GO:0007049;mitotic metaphase chromosome alignment#GO:0007080;mitotic cell cycle#GO:0000278;reproductive process#GO:0022414;organelle localization#GO:0051640;attachment of mitotic spindle microtubules to kinetochore#GO:0051315;sexual reproduction#GO:0019953;microtubule cytoskeleton organization#GO:0000226;organelle fission#GO:0048285;localization#GO:0051179;kinetochore organization#GO:0051383;attachment of spindle microtubules to kinetochore#GO:0008608;organelle organization#GO:0006996;cellular process#GO:0009987;chromosome localization#GO:0050000;cytoskeleton organization#GO:0007010;metaphase chromosome alignment#GO:0051310;meiotic cell cycle#GO:0051321;chromosome segregation#GO:0007059;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;sister chromatid segregation#GO:0000819;nuclear chromosome segregation#GO:0098813;cellular component organization#GO:0016043;meiotic cell cycle process#GO:1903046;cell cycle process#GO:0022402;mitotic nuclear division#GO:0140014;mitotic spindle organization#GO:0007052;nuclear division#GO:0000280 intracellular anatomical structure#GO:0005622;chromosomal region#GO:0098687;membraneless organelle#GO:0043228;outer kinetochore#GO:0000940;intracellular organelle#GO:0043229;chromosome, centromeric region#GO:0000775;condensed chromosome#GO:0000793;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;supramolecular complex#GO:0099080;kinetochore#GO:0000776;condensed chromosome, centromeric region#GO:0000779;chromosome#GO:0005694 non-motor microtubule binding protein#PC00166;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=18306|UniProtKB=Q8TAE7 Q8TAE7 KCNG3 PTHR11537:SF91 VOLTAGE-GATED POTASSIUM CHANNEL VOLTAGE-GATED POTASSIUM CHANNEL REGULATORY SUBUNIT KCNG3 potassium channel regulator activity#GO:0015459;transporter regulator activity#GO:0141108;ion channel regulator activity#GO:0099106;channel regulator activity#GO:0016247;molecular function regulator activity#GO:0098772 monoatomic cation transport#GO:0006812;localization#GO:0051179;transmembrane transport#GO:0055085;monoatomic ion transport#GO:0006811;regulation of biological quality#GO:0065008;action potential#GO:0001508;metal ion transport#GO:0030001;transport#GO:0006810;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;cellular process#GO:0009987;potassium ion transport#GO:0006813;monoatomic cation transmembrane transport#GO:0098655;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;monoatomic ion transmembrane transport#GO:0034220 voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;membrane#GO:0016020;membrane protein complex#GO:0098796;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;plasma membrane#GO:0005886 ion channel#PC00133;voltage-gated ion channel#PC00241 HUMAN|HGNC=26472|UniProtKB=Q96MW1 Q96MW1 CCDC43 PTHR31684:SF2 COILED-COIL DOMAIN-CONTAINING PROTEIN 43 COILED-COIL DOMAIN-CONTAINING PROTEIN 43 HUMAN|HGNC=53927|UniProtKB=A0A1B0GVX0 A0A1B0GVX0 LITAFD PTHR23292:SF27 LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR LITAF DOMAIN-CONTAINING PROTEIN zinc ion binding#GO:0008270;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;transition metal ion binding#GO:0046914;metal ion binding#GO:0046872;cation binding#GO:0043169 regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of cytokine production#GO:0001817;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255 side of membrane#GO:0098552;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome membrane#GO:0010008;endosome#GO:0005768;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;lytic vacuole membrane#GO:0098852;vesicle#GO:0031982;lysosome#GO:0005764;lytic vacuole#GO:0000323;vacuolar membrane#GO:0005774;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;late endosome membrane#GO:0031902;cytoplasmic side of membrane#GO:0098562;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;late endosome#GO:0005770;vacuole#GO:0005773;cytoplasm#GO:0005737;vesicle membrane#GO:0012506;membrane#GO:0016020;lysosomal membrane#GO:0005765;nucleus#GO:0005634 scaffold/adaptor protein#PC00226 HUMAN|HGNC=31010|UniProtKB=Q2TAM9 Q2TAM9 TUSC1 PTHR34768:SF3 COILED-COIL DOMAIN-CONTAINING PROTEIN 89 TUMOR SUPPRESSOR CANDIDATE GENE 1 PROTEIN HUMAN|HGNC=21092|UniProtKB=Q5T2D2 Q5T2D2 TREML2 PTHR16423:SF3 TREM-LIKE TRANSCRIPT PROTEIN TREM-LIKE TRANSCRIPT 2 PROTEIN signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 lymphocyte activation#GO:0046649;multicellular organismal process#GO:0032501;cell activation#GO:0001775;cellular process#GO:0009987;immune system process#GO:0002376;leukocyte activation#GO:0045321;T cell activation#GO:0042110 cellular anatomical structure#GO:0110165;cell surface#GO:0009986 HUMAN|HGNC=15922|UniProtKB=O75628 O75628 REM1 PTHR45775:SF2 RAD, GEM/KIR FAMILY MEMBER 2, ISOFORM C GTP-BINDING PROTEIN REM 1 binding#GO:0005488;nucleoside phosphate binding#GO:1901265;guanyl nucleotide binding#GO:0019001;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;calcium channel regulator activity#GO:0005246;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167;transporter regulator activity#GO:0141108;channel regulator activity#GO:0016247;ion channel regulator activity#GO:0099106;molecular function regulator activity#GO:0098772;nucleotide binding#GO:0000166 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HUMAN|HGNC=16271|UniProtKB=Q9H4I0 Q9H4I0 RAD21L1 PTHR12585:SF19 SCC1 / RAD21 FAMILY MEMBER DOUBLE-STRAND-BREAK REPAIR PROTEIN RAD21-LIKE PROTEIN 1 binding#GO:0005488;chromatin binding#GO:0003682 response to stimulus#GO:0050896;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;nucleic acid metabolic process#GO:0090304;cell cycle#GO:0007049;cellular response to stimulus#GO:0051716;double-strand break repair via homologous recombination#GO:0000724;cell cycle process#GO:0022402;sister chromatid cohesion#GO:0007062;recombinational repair#GO:0000725;cellular response to stress#GO:0033554;nucleobase-containing compound metabolic process#GO:0006139;response to stress#GO:0006950;replication-born double-strand break repair via sister chromatid exchange#GO:1990414;organelle organization#GO:0006996;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;chromosome organization#GO:0051276;double-strand break repair#GO:0006302;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA recombination#GO:0006310;DNA damage response#GO:0006974 organelle#GO:0043226;cohesin complex#GO:0008278;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;chromosome#GO:0005694;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=13596|UniProtKB=Q8TCJ0 Q8TCJ0 FBXO25 PTHR13123:SF8 LD30288P F-BOX ONLY PROTEIN 25 post-translational protein modification#GO:0043687;protein ubiquitination#GO:0016567;protein modification process#GO:0036211;primary metabolic process#GO:0044238;cellular process#GO:0009987;protein modification by small protein conjugation#GO:0032446;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647 transferase complex#GO:1990234;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ubiquitin ligase complex#GO:0000151;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;SCF ubiquitin ligase complex#GO:0019005 HUMAN|HGNC=22209|UniProtKB=Q9ULQ0 Q9ULQ0 STRIP2 PTHR13239:SF6 PROTEIN REQUIRED FOR HYPHAL ANASTOMOSIS HAM-2 STRIATIN-INTERACTING PROTEIN 2 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;negative regulation of hippo signaling#GO:0035331;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;cellular component organization#GO:0016043;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of hippo signaling#GO:0035330;regulation of cell communication#GO:0010646;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;cellular component organization or biogenesis#GO:0071840;organelle organization#GO:0006996;cellular process#GO:0009987;negative regulation of response to stimulus#GO:0048585;negative regulation of signal transduction#GO:0009968;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 HUMAN|HGNC=28133|UniProtKB=Q9BTA0 Q9BTA0 FAM167B PTHR32289:SF4 PROTEIN FAM167A PROTEIN FAM167B HUMAN|HGNC=3153|UniProtKB=Q16610 Q16610 ECM1 PTHR16776:SF3 EXTRACELLULAR MATRIX PROTEIN 1 EXTRACELLULAR MATRIX PROTEIN 1 regulation of biological process#GO:0050789;regulation of multicellular organismal development#GO:2000026;regulation of developmental process#GO:0050793;biological regulation#GO:0065007;regulation of multicellular organismal process#GO:0051239;regulation of bone mineralization#GO:0030500 HUMAN|HGNC=29983|UniProtKB=Q9HA38 Q9HA38 ZMAT3 PTHR46786:SF1 ZINC FINGER MATRIN-TYPE PROTEIN 3 ZINC FINGER MATRIN-TYPE PROTEIN 3 RNA metabolism protein#PC00031;RNA processing factor#PC00147 p53 pathway#P00059>PAG608#G04690 HUMAN|HGNC=14103|UniProtKB=O15013 O15013 ARHGEF10 PTHR12877:SF14 RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 10 molecular function regulator activity#GO:0098772;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234;guanyl-nucleotide exchange factor activity#GO:0005085 nuclear division#GO:0000280;positive regulation of cellular component organization#GO:0051130;positive regulation of organelle organization#GO:0010638;regulation of actin filament bundle assembly#GO:0032231;sister chromatid segregation#GO:0000819;nuclear chromosome segregation#GO:0098813;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;cell cycle process#GO:0022402;mitotic nuclear division#GO:0140014;regulation of organelle organization#GO:0033043;regulation of cellular component organization#GO:0051128;mitotic spindle organization#GO:0007052;regulation of cellular component biogenesis#GO:0044087;chromosome segregation#GO:0007059;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;spindle assembly#GO:0051225;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;cellular component assembly#GO:0022607;positive regulation of cellular component biogenesis#GO:0044089;cytoskeleton organization#GO:0007010;regulation of actin cytoskeleton organization#GO:0032956;organelle assembly#GO:0070925;actin filament-based process#GO:0030029;organelle fission#GO:0048285;microtubule cytoskeleton organization#GO:0000226;cell cycle#GO:0007049;microtubule cytoskeleton organization involved in mitosis#GO:1902850;regulation of supramolecular fiber organization#GO:1902903;regulation of cytoskeleton organization#GO:0051493;mitotic cell cycle#GO:0000278;actin cytoskeleton organization#GO:0030036;regulation of cellular process#GO:0050794;regulation of stress fiber assembly#GO:0051492;regulation of actin filament-based process#GO:0032970;spindle organization#GO:0007051;mitotic cell cycle process#GO:1903047;positive regulation of actin filament bundle assembly#GO:0032233;chromosome organization#GO:0051276;mitotic sister chromatid segregation#GO:0000070;positive regulation of cellular process#GO:0048522;mitotic spindle assembly#GO:0090307;regulation of actin filament organization#GO:0110053;biological regulation#GO:0065007 microtubule cytoskeleton#GO:0015630;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;centrosome#GO:0005813;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 G-protein modulator#PC00022;protein-binding activity modulator#PC00095;guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=9397|UniProtKB=Q9ULU4 Q9ULU4 ZMYND8 PTHR46453:SF3 PROTEIN KINASE C-BINDING PROTEIN 1 MYND-TYPE ZINC FINGER-CONTAINING CHROMATIN READER ZMYND8 transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110 nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=29604|UniProtKB=P0DP58 P0DP58 LYNX1 PTHR16983:SF27 UPAR/LY6 DOMAIN-CONTAINING PROTEIN LY-6_NEUROTOXIN-LIKE PROTEIN 1 protein binding#GO:0005515;signaling receptor inhibitor activity#GO:0030547;neurotransmitter receptor regulator activity#GO:0099602;molecular function inhibitor activity#GO:0140678;acetylcholine receptor inhibitor activity#GO:0030550;signaling receptor binding#GO:0005102;binding#GO:0005488;acetylcholine receptor regulator activity#GO:0030548;molecular function regulator activity#GO:0098772;signaling receptor regulator activity#GO:0030545 cell communication#GO:0007154;response to nitrogen compound#GO:1901698;cellular response to chemical stimulus#GO:0070887;response to oxygen-containing compound#GO:1901700;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to chemical#GO:0042221;acetylcholine receptor signaling pathway#GO:0095500;cellular response to nitrogen compound#GO:1901699;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;synaptic signaling#GO:0099536;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 protein-binding activity modulator#PC00095 HUMAN|HGNC=17945|UniProtKB=P81277 P81277 PRLH PTHR17206:SF1 PROLACTIN-RELEASING PEPTIDE PROLACTIN-RELEASING PEPTIDE protein binding#GO:0005515;hormone activity#GO:0005179;molecular function activator activity#GO:0140677;signaling receptor binding#GO:0005102;binding#GO:0005488;neuropeptide hormone activity#GO:0005184;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;neuropeptide receptor binding#GO:0071855;G protein-coupled receptor binding#GO:0001664 signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to endogenous stimulus#GO:0009719;response to nitrogen compound#GO:1901698;cell communication#GO:0007154;response to oxygen-containing compound#GO:1901700;G protein-coupled receptor signaling pathway#GO:0007186;biological regulation#GO:0065007;response to peptide hormone#GO:0043434;response to chemical#GO:0042221;multicellular organismal process#GO:0032501;signal transduction#GO:0007165;cellular process#GO:0009987;response to hormone#GO:0009725;feeding behavior#GO:0007631 HUMAN|HGNC=6440|UniProtKB=P12035 P12035 KRT3 PTHR45616:SF38 GATA-TYPE DOMAIN-CONTAINING PROTEIN KERATIN, TYPE II CYTOSKELETAL 3 structural molecule activity#GO:0005198 organelle organization#GO:0006996;cellular process#GO:0009987;multicellular organismal process#GO:0032501;epithelial cell differentiation#GO:0030855;tissue development#GO:0009888;epidermal cell differentiation#GO:0009913;epithelium development#GO:0060429;skin development#GO:0043588;cytoskeleton organization#GO:0007010;epidermis development#GO:0008544;developmental process#GO:0032502;animal organ development#GO:0048513;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;intermediate filament cytoskeleton organization#GO:0045104;cell differentiation#GO:0030154;keratinocyte differentiation#GO:0030216;animal gross anatomical part developmental process#GO:0160108;intermediate filament-based process#GO:0045103;intermediate filament organization#GO:0045109;anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435 intracellular membraneless organelle#GO:0043232;organelle#GO:0043226;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;supramolecular fiber#GO:0099512;intermediate filament#GO:0005882;intracellular anatomical structure#GO:0005622;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228 HUMAN|HGNC=13221|UniProtKB=Q9H165 Q9H165 BCL11A PTHR45993:SF5 B-CELL LYMPHOMA/LEUKEMIA 11 BCL11 TRANSCRIPTION FACTOR A RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of developmental process#GO:0050793;regulation of dendrite development#GO:0050773;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;negative regulation of cellular component organization#GO:0051129;negative regulation of biological process#GO:0048519;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of plasma membrane bounded cell projection organization#GO:0120035;negative regulation of cellular process#GO:0048523;regulation of cell projection organization#GO:0031344;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of neuron projection development#GO:0010975;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218;C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244 HUMAN|HGNC=9711|UniProtKB=Q15269 Q15269 PWP2 PTHR19858:SF0 WD40 REPEAT PROTEIN PERIODIC TRYPTOPHAN PROTEIN 2 HOMOLOG macromolecule biosynthetic process#GO:0009059;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;rRNA metabolic process#GO:0016072;macromolecule metabolic process#GO:0043170;ribosomal small subunit assembly#GO:0000028;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;organelle assembly#GO:0070925;protein-RNA complex assembly#GO:0022618;rRNA processing#GO:0006364;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cellular component assembly#GO:0022607;gene expression#GO:0010467;maturation of SSU-rRNA#GO:0030490;RNA processing#GO:0006396;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;ribosomal small subunit biogenesis#GO:0042274;cellular component organization or biogenesis#GO:0071840;protein-RNA complex organization#GO:0071826;protein-containing complex organization#GO:0043933;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;protein-containing complex assembly#GO:0065003;ribonucleoprotein complex biogenesis#GO:0022613;maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000462;ribosome assembly#GO:0042255;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070 cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;90S preribosome#GO:0030686;small-subunit processome#GO:0032040;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;preribosome#GO:0030684;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513 HUMAN|HGNC=26567|UniProtKB=Q96LZ7 Q96LZ7 RMDN2 PTHR16056:SF15 REGULATOR OF MICROTUBULE DYNAMICS PROTEIN REGULATOR OF MICROTUBULE DYNAMICS PROTEIN 2 protein binding#GO:0005515;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;microtubule binding#GO:0008017 polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;spindle#GO:0005819;cytoskeleton#GO:0005856;supramolecular complex#GO:0099080;supramolecular polymer#GO:0099081;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630;mitotic spindle pole#GO:0097431;microtubule#GO:0005874;spindle microtubule#GO:0005876;membrane-bounded organelle#GO:0043227;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitotic spindle#GO:0072686;intracellular membrane-bounded organelle#GO:0043231;spindle pole#GO:0000922;mitochondrion#GO:0005739 non-motor microtubule binding protein#PC00166;cytoskeletal protein#PC00085;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=18744|UniProtKB=Q9GZS0 Q9GZS0 DNAI2 PTHR12442:SF7 DYNEIN INTERMEDIATE CHAIN DYNEIN AXONEMAL INTERMEDIATE CHAIN 2 protein binding#GO:0005515;binding#GO:0005488 cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;outer dynein arm assembly#GO:0036158;cell projection assembly#GO:0030031;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;microtubule-based process#GO:0007017;plasma membrane bounded cell projection assembly#GO:0120031;microtubule-based movement#GO:0007018;cell projection organization#GO:0030030;cellular component organization#GO:0016043;cilium assembly#GO:0060271;protein-containing complex assembly#GO:0065003;microtubule cytoskeleton organization#GO:0000226;cilium organization#GO:0044782;axoneme assembly#GO:0035082;organelle assembly#GO:0070925;axonemal dynein complex assembly#GO:0070286;microtubule bundle formation#GO:0001578;cilium movement#GO:0003341 microtubule cytoskeleton#GO:0015630;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;ciliary plasm#GO:0097014;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;cytoskeleton#GO:0005856;outer dynein arm#GO:0036157;membraneless organelle#GO:0043228;axonemal dynein complex#GO:0005858;dynein complex#GO:0030286;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;intracellular organelle#GO:0043229;cilium#GO:0005929;catalytic complex#GO:1902494;axoneme#GO:0005930;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 microtubule or microtubule-binding cytoskeletal protein#PC00157 Huntington disease#P00029>Dynein complex#P00774 HUMAN|HGNC=28805|UniProtKB=Q9H4I3 Q9H4I3 TRABD PTHR21530:SF7 PHEROMONE SHUTDOWN PROTEIN TRAB DOMAIN-CONTAINING PROTEIN HUMAN|HGNC=18414|UniProtKB=Q96RP3 Q96RP3 UCN2 PTHR17575:SF0 UROCORTIN-2 AND 3 UROCORTIN-2 G protein-coupled receptor binding#GO:0001664;binding#GO:0005488;hormone receptor binding#GO:0051427;signaling receptor binding#GO:0005102;neuropeptide receptor binding#GO:0071855;protein binding#GO:0005515 signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;regulation of biological process#GO:0050789;signal transduction#GO:0007165;response to nutrient levels#GO:0031667;cell communication#GO:0007154;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cellular response to nutrient levels#GO:0031669;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;G protein-coupled receptor signaling pathway#GO:0007186 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=28313|UniProtKB=O43151 O43151 TET3 PTHR23358:SF4 METHYLCYTOSINE DIOXYGENASE TET METHYLCYTOSINE DIOXYGENASE TET3 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;oxidoreductase activity#GO:0016491;catalytic activity, acting on DNA#GO:0140097;dioxygenase activity#GO:0051213 regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of transcription by RNA polymerase II#GO:0045944 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=4445|UniProtKB=Q99795 Q99795 GPA33 PTHR44969:SF1 CELL SURFACE A33 ANTIGEN CELL SURFACE A33 ANTIGEN membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 HUMAN|HGNC=1884|UniProtKB=P13569 P13569 CFTR PTHR24223:SF19 ATP-BINDING CASSETTE SUB-FAMILY C CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR gated channel activity#GO:0022836;chloride channel activity#GO:0005254;monoatomic anion transmembrane transporter activity#GO:0008509;transporter activity#GO:0005215;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;polypeptide conformation or assembly isomerase activity#GO:0120544;ligand-gated monoatomic ion channel activity#GO:0015276;monoatomic anion channel activity#GO:0005253;channel activity#GO:0015267;catalytic activity#GO:0003824;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;chloride transmembrane transporter activity#GO:0015108;macromolecular conformation isomerase activity#GO:0120543;transmembrane transporter activity#GO:0022857;isomerase activity#GO:0016853 monoatomic anion transport#GO:0006820;cellular process#GO:0009987;monoatomic anion transmembrane transport#GO:0098656;monoatomic ion transmembrane transport#GO:0034220;chloride transport#GO:0006821;transport#GO:0006810;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;chloride transmembrane transport#GO:1902476;water transport#GO:0006833;localization#GO:0051179;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698;fluid transport#GO:0042044 intracellular anatomical structure#GO:0005622;apical part of cell#GO:0045177;cytoplasm#GO:0005737;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;cell periphery#GO:0071944;basal plasma membrane#GO:0009925;membrane#GO:0016020;basal part of cell#GO:0045178;cytosol#GO:0005829;basolateral plasma membrane#GO:0016323;apical plasma membrane#GO:0016324 ATP-binding cassette (ABC) transporter#PC00003 HUMAN|HGNC=712|UniProtKB=P32121 P32121 ARRB2 PTHR11792:SF20 ARRESTIN BETA-ARRESTIN-2 protein binding#GO:0005515;binding#GO:0005488;signaling receptor binding#GO:0005102;G protein-coupled receptor binding#GO:0001664 negative regulation of G protein-coupled receptor signaling pathway#GO:0045744;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;positive regulation of ERK1 and ERK2 cascade#GO:0070374;modulation of chemical synaptic transmission#GO:0050804;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;sensory perception#GO:0007600;localization#GO:0051179;positive regulation of cellular process#GO:0048522;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of response to stimulus#GO:0048585;multicellular organismal process#GO:0032501;positive regulation of response to stimulus#GO:0048584;transport#GO:0006810;regulation of response to stimulus#GO:0048583;regulation of G protein-coupled receptor signaling pathway#GO:0008277;positive regulation of intracellular signal transduction#GO:1902533;negative regulation of cellular process#GO:0048523;receptor-mediated endocytosis#GO:0006898;system process#GO:0003008;positive regulation of MAPK cascade#GO:0043410;establishment of localization#GO:0051234;regulation of biological process#GO:0050789;sensory perception of pain#GO:0019233;negative regulation of biological process#GO:0048519;endocytosis#GO:0006897;nervous system process#GO:0050877;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648;positive regulation of signaling#GO:0023056;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;receptor internalization#GO:0031623;negative regulation of signal transduction#GO:0009968;vesicle-mediated transport#GO:0016192;regulation of trans-synaptic signaling#GO:0099177;regulation of ERK1 and ERK2 cascade#GO:0070372;regulation of MAPK cascade#GO:0043408;import into cell#GO:0098657 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 Angiotensin II-stimulated signaling through G proteins and beta-arrestin#P05911>beta-ARR2#P05923;CCKR signaling map#P06959>Beta-arrestin-1/2#P07187;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>beta-arrestin#P00723;Wnt signaling pathway#P00057>beta-arrestin#P01456;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>beta-arrestin#P00880 HUMAN|HGNC=14906|UniProtKB=Q8N4C6 Q8N4C6 NIN PTHR18905:SF11 NINEIN NINEIN supramolecular fiber organization#GO:0097435;microtubule cytoskeleton organization#GO:0000226;localization#GO:0051179;centrosome localization#GO:0051642;protein polymerization#GO:0051258;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;microtubule nucleation#GO:0007020;protein-containing complex organization#GO:0043933;microtubule polymerization#GO:0046785;microtubule-based process#GO:0007017;microtubule anchoring#GO:0034453;microtubule anchoring at microtubule organizing center#GO:0072393;cellular component organization or biogenesis#GO:0071840;cytoskeleton organization#GO:0007010;cellular component assembly#GO:0022607;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;microtubule polymerization or depolymerization#GO:0031109;organelle organization#GO:0006996 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cilium#GO:0005929;plasma membrane bounded cell projection#GO:0120025;mitotic spindle#GO:0072686;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;spindle pole#GO:0000922;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;centrosome#GO:0005813;microtubule organizing center#GO:0005815;spindle#GO:0005819;intracellular membraneless organelle#GO:0043232;centriole#GO:0005814;protein-containing complex#GO:0032991;ciliary transition fiber#GO:0097539;mitotic spindle pole#GO:0097431;microtubule cytoskeleton#GO:0015630 PDGF signaling pathway#P00047>GSK3#P01153 HUMAN|HGNC=26355|UniProtKB=Q6PF05 Q6PF05 TTC23L PTHR14485:SF4 TETRATRICOPEPTIDE REPEAT PROTEIN 23 TETRATRICOPEPTIDE REPEAT PROTEIN 23-LIKE HUMAN|HGNC=17407|UniProtKB=Q5HYM0 Q5HYM0 ZC3H12B PTHR12876:SF27 N4BP1-RELATED RIBONUCLEASE ZC3H12B-RELATED RNA binding#GO:0003723;nuclease activity#GO:0004518;nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;RNA endonuclease activity#GO:0004521;catalytic activity, acting on RNA#GO:0140098;endonuclease activity#GO:0004519;RNA nuclease activity#GO:0004540;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640 regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;positive regulation of catabolic process#GO:0009896;regulation of biosynthetic process#GO:0009889;negative regulation of cellular process#GO:0048523;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of RNA stability#GO:0043487;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of mRNA catabolic process#GO:0061014;regulation of mRNA metabolic process#GO:1903311;mRNA destabilization#GO:0061157;positive regulation of mRNA metabolic process#GO:1903313;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;RNA destabilization#GO:0050779;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of biological quality#GO:0065008;positive regulation of metabolic process#GO:0009893;regulation of mRNA stability#GO:0043488;negative regulation of metabolic process#GO:0009892;regulation of biological process#GO:0050789;negative regulation of gene expression#GO:0010629;regulation of mRNA catabolic process#GO:0061013;negative regulation of biological process#GO:0048519 intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;cytoplasmic ribonucleoprotein granule#GO:0036464;organelle#GO:0043226;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232 endoribonuclease#PC00094 HUMAN|HGNC=34521|UniProtKB=Q6ZU45 Q6ZU45 CLEC20A PTHR45784:SF5 C-TYPE LECTIN DOMAIN FAMILY 20 MEMBER A-RELATED C-TYPE LECTIN DOMAIN FAMILY 20 MEMBER A-RELATED HUMAN|HGNC=29571|UniProtKB=Q969E1 Q969E1 LEAP2 PTHR21007:SF1 LIVER EXPRESSED ANTIMICROBIAL PEPTIDE 2 LIVER-EXPRESSED ANTIMICROBIAL PEPTIDE 2 HUMAN|HGNC=18568|UniProtKB=Q96LI6 Q96LI6 HSFY1 PTHR10015:SF336 HEAT SHOCK TRANSCRIPTION FACTOR HEAT SHOCK TRANSCRIPTION FACTOR, Y-LINKED helix-turn-helix transcription factor#PC00116;gene-specific transcriptional regulator#PC00264;winged helix/forkhead transcription factor#PC00246 HUMAN|HGNC=24554|UniProtKB=Q6UXH9 Q6UXH9 PAMR1 PTHR24254:SF9 PROTHROMBIN INACTIVE SERINE PROTEASE PAMR1 serine protease#PC00203;protease#PC00190;protein modifying enzyme#PC00260 HUMAN|HGNC=7398|UniProtKB=P04733 P04733 MT1F PTHR23299:SF55 METALLOTHIONEIN METALLOTHIONEIN-1F ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;cation binding#GO:0043169;metal ion binding#GO:0046872 response to cadmium ion#GO:0046686;response to metal ion#GO:0010038;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;detoxification of inorganic compound#GO:0061687;monoatomic ion homeostasis#GO:0050801;response to stress#GO:0006950;cellular process#GO:0009987;response to chemical#GO:0042221;detoxification#GO:0098754;cellular response to chemical stimulus#GO:0070887;inorganic ion homeostasis#GO:0098771;intracellular monoatomic ion homeostasis#GO:0006873;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;response to toxic substance#GO:0009636;homeostatic process#GO:0042592 nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 defense/immunity protein#PC00090 HUMAN|HGNC=23298|UniProtKB=O95858 O95858 TSPAN15 PTHR19282:SF159 TETRASPANIN TETRASPANIN-15 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=28454|UniProtKB=Q9BUN8 Q9BUN8 DERL1 PTHR11009:SF1 DER1-LIKE PROTEIN, DERLIN DERLIN-1 response to unfolded protein#GO:0006986;cell communication#GO:0007154;protein metabolic process#GO:0019538;ERAD pathway#GO:0036503;intracellular signal transduction#GO:0035556;cellular response to unfolded protein#GO:0034620;response to endoplasmic reticulum stress#GO:0034976;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;cellular response to topologically incorrect protein#GO:0035967;response to stimulus#GO:0050896;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;response to topologically incorrect protein#GO:0035966;signaling#GO:0023052;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;response to chemical#GO:0042221;biological regulation#GO:0065007;proteasomal protein catabolic process#GO:0010498;endoplasmic reticulum unfolded protein response#GO:0030968;response to stress#GO:0006950;signal transduction#GO:0007165;cellular process#GO:0009987 membrane#GO:0016020;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum membrane#GO:0005789;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum#GO:0005783;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090 transporter#PC00227;primary active transporter#PC00068 HUMAN|HGNC=28112|UniProtKB=Q15024 Q15024 EXOSC7 PTHR11097:SF8 EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN EXOSOME COMPLEX COMPONENT RRP42 nucleic acid binding#GO:0003676;binding#GO:0005488;mRNA binding#GO:0003729;RNA binding#GO:0003723;mRNA 3'-UTR binding#GO:0003730 RNA catabolic process#GO:0006401;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;rRNA metabolic process#GO:0016072;macromolecule metabolic process#GO:0043170;RNA metabolic process#GO:0016070;cellular process#GO:0009987;nucleic acid catabolic process#GO:0141188;nucleobase-containing compound catabolic process#GO:0034655;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;nucleobase-containing compound metabolic process#GO:0006139;catabolic process#GO:0009056 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494 exoribonuclease#PC00099;RNA metabolism protein#PC00031 HUMAN|HGNC=13479|UniProtKB=Q9BY64 Q9BY64 UGT2B28 PTHR48043:SF86 EG:EG0003.4 PROTEIN-RELATED UDP-GLUCURONOSYLTRANSFERASE 2B10-RELATED glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194;hexosyltransferase activity#GO:0016758;transferase activity#GO:0016740;catalytic activity#GO:0003824;glucuronosyltransferase activity#GO:0015020 steroid metabolic process#GO:0008202;biological regulation#GO:0065007;hormone metabolic process#GO:0042445;cellular process#GO:0009987;regulation of hormone levels#GO:0010817;primary metabolic process#GO:0044238;regulation of biological quality#GO:0065008;estrogen metabolic process#GO:0008210;lipid metabolic process#GO:0006629;metabolic process#GO:0008152 HUMAN|HGNC=11279|UniProtKB=Q14534 Q14534 SQLE PTHR10835:SF0 SQUALENE MONOOXYGENASE SQUALENE MONOOXYGENASE oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen#GO:0016712;catalytic activity#GO:0003824;monooxygenase activity#GO:0004497;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705 lipid metabolic process#GO:0006629;metabolic process#GO:0008152;sterol metabolic process#GO:0016125;steroid biosynthetic process#GO:0006694;cellular process#GO:0009987;primary metabolic process#GO:0044238;steroid metabolic process#GO:0008202;biosynthetic process#GO:0009058;sterol biosynthetic process#GO:0016126;lipid biosynthetic process#GO:0008610 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 oxygenase#PC00177 Cholesterol biosynthesis#P00014>Squalene monooxygenas#P00494 HUMAN|HGNC=28330|UniProtKB=Q8TBQ9 Q8TBQ9 TMEM167A PTHR13229:SF2 PROTEIN KISH-A PROTEIN KISH-A transport#GO:0006810;protein secretion#GO:0009306;localization#GO:0051179;establishment of localization#GO:0051234;secretion#GO:0046903;intracellular protein localization#GO:0008104;secretion by cell#GO:0032940;establishment of protein localization to extracellular region#GO:0035592;protein transport#GO:0015031;macromolecule localization#GO:0033036;establishment of protein localization#GO:0045184;protein localization to extracellular region#GO:0071692;cellular process#GO:0009987;export from cell#GO:0140352 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=13886|UniProtKB=Q9H222 Q9H222 ABCG5 PTHR48041:SF113 ABC TRANSPORTER G FAMILY MEMBER 28 ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 5 transmembrane transporter activity#GO:0022857;sterol transfer activity#GO:0120015;transporter activity#GO:0005215;cholesterol transfer activity#GO:0120020;active transmembrane transporter activity#GO:0022804;primary active transmembrane transporter activity#GO:0015399;molecular carrier activity#GO:0140104;lipid carrier activity#GO:0005319;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626;lipid transfer activity#GO:0120013 organic hydroxy compound transport#GO:0015850;transmembrane transport#GO:0055085;localization#GO:0051179;lipid localization#GO:0010876;homeostatic process#GO:0042592;lipid homeostasis#GO:0055088;sterol transport#GO:0015918;establishment of localization#GO:0051234;cholesterol homeostasis#GO:0042632;transport#GO:0006810;chemical homeostasis#GO:0048878;lipid transport#GO:0006869;cellular process#GO:0009987;cholesterol efflux#GO:0033344;cholesterol transport#GO:0030301;macromolecule localization#GO:0033036 transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;ATPase dependent transmembrane transport complex#GO:0098533;apical part of cell#GO:0045177;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;plasma membrane#GO:0005886;membrane#GO:0016020;membrane protein complex#GO:0098796;apical plasma membrane#GO:0016324;ATP-binding cassette (ABC) transporter complex#GO:0043190;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944 ATP-binding cassette (ABC) transporter#PC00003;transporter#PC00227;primary active transporter#PC00068 HUMAN|HGNC=9849|UniProtKB=O14715 O14715 RGPD8 PTHR23138:SF175 RAN BINDING PROTEIN E3 SUMO-PROTEIN LIGASE RANBP2-RELATED aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;SUMO transferase activity#GO:0019789;acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824 establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;transport#GO:0006810;intracellular protein transport#GO:0006886;import into nucleus#GO:0051170;macromolecule localization#GO:0033036;protein localization to nucleus#GO:0034504;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;NLS-bearing protein import into nucleus#GO:0006607;localization#GO:0051179;cellular localization#GO:0051641;nuclear transport#GO:0051169;nuclear export#GO:0051168;protein transport#GO:0015031;protein import into nucleus#GO:0006606;nucleocytoplasmic transport#GO:0006913;protein localization to organelle#GO:0033365 organelle envelope#GO:0031967;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;nuclear pore#GO:0005643;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HUMAN|HGNC=1697|UniProtKB=P04233 P04233 CD74 PTHR14093:SF17 HLA CLASS II GAMMA CHAIN HLA CLASS II HISTOCOMPATIBILITY ANTIGEN GAMMA CHAIN MHC protein binding#GO:0042287;signaling receptor binding#GO:0005102;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;protein binding#GO:0005515;cytokine receptor activity#GO:0004896;immune receptor activity#GO:0140375;cytokine binding#GO:0019955;signaling receptor activity#GO:0038023 leukocyte activation involved in immune response#GO:0002366;regulation of cytokine-mediated signaling pathway#GO:0001959;negative regulation of programmed cell death#GO:0043069;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of immune system process#GO:0002684;negative regulation of signal transduction#GO:0009968;lymphocyte activation#GO:0046649;positive regulation of macromolecule metabolic process#GO:0010604;regulation of ERK1 and ERK2 cascade#GO:0070372;regulation of signaling#GO:0023051;regulation of cytokine production involved in immune response#GO:0002718;immune system process#GO:0002376;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648;positive regulation of macromolecule biosynthetic process#GO:0010557;regulation of biological process#GO:0050789;positive regulation of multicellular organismal process#GO:0051240;negative regulation of biological process#GO:0048519;response to stimulus#GO:0050896;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;positive regulation of MAPK cascade#GO:0043410;regulation of biosynthetic process#GO:0009889;immune response#GO:0006955;positive regulation of cellular process#GO:0048522;regulation of cytokine production#GO:0001817;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;positive regulation of immune effector process#GO:0002699;positive regulation of response to stimulus#GO:0048584;multicellular organismal process#GO:0032501;negative regulation of response to stimulus#GO:0048585;regulation of immune response#GO:0050776;negative regulation of apoptotic signaling pathway#GO:2001234;regulation of apoptotic signaling pathway#GO:2001233;antigen processing and presentation#GO:0019882;regulation of immune effector process#GO:0002697;positive regulation of signal transduction#GO:0009967;regulation of cell communication#GO:0010646;regulation of macromolecule metabolic process#GO:0060255;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;regulation of MAPK cascade#GO:0043408;regulation of apoptotic process#GO:0042981;immune effector process#GO:0002252;negative regulation of intrinsic apoptotic signaling pathway#GO:2001243;lymphocyte activation involved in immune response#GO:0002285;regulation of response to cytokine stimulus#GO:0060759;T cell activation involved in immune response#GO:0002286;regulation of multicellular organismal process#GO:0051239;regulation of intracellular signal transduction#GO:1902531;positive regulation of cytokine-mediated signaling pathway#GO:0001961;regulation of cellular response to stress#GO:0080135;cell activation involved in immune response#GO:0002263;positive regulation of metabolic process#GO:0009893;negative regulation of intracellular signal transduction#GO:1902532;positive regulation of signaling#GO:0023056;regulation of programmed cell death#GO:0043067;T cell activation#GO:0042110;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stress#GO:0080134;positive regulation of gene expression#GO:0010628;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of signal transduction#GO:0009966;negative regulation of apoptotic process#GO:0043066;cell activation#GO:0001775;positive regulation of biosynthetic process#GO:0009891;regulation of intrinsic apoptotic signaling pathway#GO:2001242;leukocyte activation#GO:0045321;positive regulation of ERK1 and ERK2 cascade#GO:0070374;positive regulation of cell communication#GO:0010647;positive regulation of cytokine production#GO:0001819 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;cell surface#GO:0009986 scaffold/adaptor protein#PC00226 T cell activation#P00053>MHC-antigen#P01316 HUMAN|HGNC=4897|UniProtKB=O14964 O14964 HGS PTHR46275:SF1 HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASE SUBSTRATE HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASE SUBSTRATE binding#GO:0005488;ubiquitin binding#GO:0043130;protein binding#GO:0005515 cellular localization#GO:0051641;localization#GO:0051179;localization within membrane#GO:0051668;endocytosis#GO:0006897;endocytic recycling#GO:0032456;import into cell#GO:0098657;establishment of localization#GO:0051234;endosomal transport#GO:0016197;receptor-mediated endocytosis#GO:0006898;vesicle-mediated transport to the plasma membrane#GO:0098876;intracellular transport#GO:0046907;transport#GO:0006810;vesicle-mediated transport#GO:0016192;receptor internalization#GO:0031623;cellular process#GO:0009987;establishment of localization in cell#GO:0051649 intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;early endosome#GO:0005769;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular vesicle#GO:0097708 HUMAN|HGNC=19023|UniProtKB=Q9BSJ1 Q9BSJ1 TRIM51 PTHR24103:SF703 E3 UBIQUITIN-PROTEIN LIGASE TRIM TRIPARTITE MOTIF-CONTAINING PROTEIN 51 transferase activity#GO:0016740;catalytic activity#GO:0003824;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842 immune system process#GO:0002376;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;response to stimulus#GO:0050896;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;innate immune response#GO:0045087;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;defense response#GO:0006952;response to external stimulus#GO:0009605;response to stress#GO:0006950;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;response to biotic stimulus#GO:0009607;defense response to symbiont#GO:0140546;immune response#GO:0006955;defense response to other organism#GO:0098542;response to other organism#GO:0051707;biological regulation#GO:0065007 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=33898|UniProtKB=Q3LI54 Q3LI54 KRTAP19-8 PTHR38140:SF3 KERATIN-ASSOCIATED PROTEIN 19-3-RELATED KERATIN-ASSOCIATED PROTEIN 19-8 structural protein#PC00211 HUMAN|HGNC=10706|UniProtKB=O94855 O94855 SEC24D PTHR13803:SF6 SEC24-RELATED PROTEIN PROTEIN TRANSPORT PROTEIN SEC24D zinc ion binding#GO:0008270;SNARE binding#GO:0000149;binding#GO:0005488;small molecule binding#GO:0036094;ion binding#GO:0043167;transition metal ion binding#GO:0046914;metal ion binding#GO:0046872;protein binding#GO:0005515;cation binding#GO:0043169 cellular component organization#GO:0016043;COPII-coated vesicle budding#GO:0090114;cellular localization#GO:0051641;localization#GO:0051179;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;organelle organization#GO:0006996;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;membrane organization#GO:0061024;intracellular transport#GO:0046907;transport#GO:0006810;Golgi vesicle transport#GO:0048193;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;vesicle organization#GO:0016050;vesicle budding from membrane#GO:0006900 cytoplasm#GO:0005737;vesicle coat#GO:0030120;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasmic vesicle membrane#GO:0030659;transport vesicle membrane#GO:0030658;transport vesicle#GO:0030133;membrane#GO:0016020;vesicle membrane#GO:0012506;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;endoplasmic reticulum#GO:0005783;endoplasmic reticulum exit site#GO:0070971;ER to Golgi transport vesicle membrane#GO:0012507;intracellular membrane-bounded organelle#GO:0043231;coated vesicle membrane#GO:0030662;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;cytoplasmic vesicle#GO:0031410;coated vesicle#GO:0030135;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;COPII-coated ER to Golgi transport vesicle#GO:0030134;membrane coat#GO:0030117;coated membrane#GO:0048475;intracellular organelle#GO:0043229 vesicle coat protein#PC00235 HUMAN|HGNC=1472|UniProtKB=P49913 P49913 CAMP PTHR10206:SF2 CATHELICIDIN CATHELICIDIN ANTIMICROBIAL PEPTIDE lipid binding#GO:0008289;carbohydrate derivative binding#GO:0097367;binding#GO:0005488;lipopolysaccharide binding#GO:0001530 innate immune response#GO:0045087;response to external stimulus#GO:0009605;defense response#GO:0006952;antimicrobial humoral response#GO:0019730;humoral immune response#GO:0006959;defense response to other organism#GO:0098542;response to other organism#GO:0051707;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;defense response to symbiont#GO:0140546;immune response#GO:0006955;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;response to bacterium#GO:0009617;immune system process#GO:0002376;defense response to bacterium#GO:0042742;response to stimulus#GO:0050896;response to external biotic stimulus#GO:0043207;defense response to Gram-negative bacterium#GO:0050829;biological process involved in interspecies interaction between organisms#GO:0044419;defense response to Gram-positive bacterium#GO:0050830 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 antimicrobial response protein#PC00051 HUMAN|HGNC=2474|UniProtKB=P09228 P09228 CST2 PTHR46186:SF3 CYSTATIN CYSTATIN-S-RELATED enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;cysteine-type endopeptidase inhibitor activity#GO:0004869;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;peptidase regulator activity#GO:0061134;endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772;enzyme inhibitor activity#GO:0004857 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;vesicle#GO:0031982;extracellular region#GO:0005576 protease inhibitor#PC00191 HUMAN|HGNC=8064|UniProtKB=P35658 P35658 NUP214 PTHR23193:SF21 NUCLEAR PORE COMPLEX PROTEIN NUP NUCLEAR PORE COMPLEX PROTEIN NUP214 structural constituent of nuclear pore#GO:0017056;structural molecule activity#GO:0005198;molecular carrier activity#GO:0140104;nucleocytoplasmic carrier activity#GO:0140142 macromolecule localization#GO:0033036;import into nucleus#GO:0051170;protein localization to nucleus#GO:0034504;nitrogen compound transport#GO:0071705;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907;transport#GO:0006810;intracellular protein transport#GO:0006886;nucleobase-containing compound transport#GO:0015931;protein localization to organelle#GO:0033365;RNA localization#GO:0006403;RNA transport#GO:0050658;establishment of RNA localization#GO:0051236;localization#GO:0051179;nucleic acid transport#GO:0050657;cellular localization#GO:0051641;nuclear transport#GO:0051169;protein transport#GO:0015031;nuclear export#GO:0051168;protein import into nucleus#GO:0006606;nucleocytoplasmic transport#GO:0006913 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;nuclear pore#GO:0005643;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226 transporter#PC00227 HUMAN|HGNC=15519|UniProtKB=Q14137 Q14137 BOP1 PTHR17605:SF0 RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN RIBOSOME BIOGENESIS PROTEIN BOP1 rRNA binding#GO:0019843;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 rRNA processing#GO:0006364;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;ribosomal large subunit biogenesis#GO:0042273;ribosome biogenesis#GO:0042254;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000463;maturation of LSU-rRNA#GO:0000470;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;90S preribosome#GO:0030686;organelle lumen#GO:0043233;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;preribosome, large subunit precursor#GO:0030687;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;nucleolus#GO:0005730;preribosome#GO:0030684;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228 ribosomal protein#PC00202 HUMAN|HGNC=28476|UniProtKB=Q9BWQ6 Q9BWQ6 YIPF2 PTHR12822:SF3 PROTEIN YIPF PROTEIN YIPF2 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=15874|UniProtKB=Q9Y4P9 Q9Y4P9 SPEF1 PTHR12509:SF16 SPERMATOGENESIS-ASSOCIATED 4-RELATED SPERM FLAGELLA AND CILIA-ASSOCIATED PROTEIN 1 protein binding#GO:0005515;microtubule binding#GO:0008017;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631 regulation of cellular process#GO:0050794;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;biological regulation#GO:0065007;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789 organelle#GO:0043226;cellular anatomical structure#GO:0110165;ciliary plasm#GO:0097014;cell projection#GO:0042995;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;plasma membrane bounded cell projection#GO:0120025;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;cilium#GO:0005929;axoneme#GO:0005930;membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=24487|UniProtKB=A6NI79 A6NI79 CCDC69 PTHR24200:SF6 TOUCAN, ISOFORM A COILED-COIL DOMAIN-CONTAINING PROTEIN 69 protein binding#GO:0005515;microtubule binding#GO:0008017;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 HUMAN|HGNC=19009|UniProtKB=Q96AJ1 Q96AJ1 CLUAP1 PTHR21547:SF0 CLUSTERIN ASSOCIATED PROTEIN 1 CLUSTERIN-ASSOCIATED PROTEIN 1 cilium assembly#GO:0060271;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component assembly#GO:0022607;cell projection organization#GO:0030030;plasma membrane bounded cell projection organization#GO:0120036;organelle assembly#GO:0070925;plasma membrane bounded cell projection assembly#GO:0120031;cellular component organization or biogenesis#GO:0071840;cilium organization#GO:0044782 protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;intraciliary transport particle B#GO:0030992;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intraciliary transport particle#GO:0030990;intracellular organelle#GO:0043229;cilium#GO:0005929 HUMAN|HGNC=23437|UniProtKB=Q96JD6 Q96JD6 AKR1E2 PTHR11732:SF391 ALDO/KETO REDUCTASE 1,5-ANHYDRO-D-FRUCTOSE REDUCTASE catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;alcohol dehydrogenase [NAD(P)+] activity#GO:0018455;oxidoreductase activity#GO:0016491;alcohol dehydrogenase (NADP+) activity#GO:0008106;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 reductase#PC00198;oxidoreductase#PC00176 HUMAN|HGNC=6844|UniProtKB=P45985 P45985 MAP2K4 PTHR48013:SF29 DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4 phosphotransferase activity, alcohol group as acceptor#GO:0016773;catalytic activity, acting on a protein#GO:0140096;protein kinase activity#GO:0004672;catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 MAPK cascade#GO:0000165;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 non-receptor serine/threonine protein kinase#PC00167 Oxidative stress response#P00046>MKK4#P01138;Ras Pathway#P04393>MKK4/7#P04565;p38 MAPK pathway#P05918>MKK4#P06034;Huntington disease#P00029>MAPKK4#P00787;FAS signaling pathway#P00020>MKK4#P00610;CCKR signaling map#P06959>MAP2K4#P07074;EGF receptor signaling pathway#P00018>MKK4,7#P00555;FGF signaling pathway#P00021>MKK4,7#P00637;Apoptosis signaling pathway#P00006>SEK1#P00266;Integrin signalling pathway#P00034>MEK#P00925;Angiogenesis#P00005>JNKK1#P00199;Huntington disease#P00029>SEK-1#P00792 HUMAN|HGNC=26971|UniProtKB=Q6UXT9 Q6UXT9 ABHD15 PTHR10794:SF39 ABHYDROLASE DOMAIN-CONTAINING PROTEIN PROTEIN ABHD15 serine protease#PC00203;protease#PC00190 HUMAN|HGNC=18622|UniProtKB=P83436 P83436 COG7 PTHR21443:SF0 CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 7 CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 7 cellular component organization#GO:0016043;macromolecule localization#GO:0033036;organelle organization#GO:0006996;cellular process#GO:0009987;Golgi organization#GO:0007030;protein localization to organelle#GO:0033365;endomembrane system organization#GO:0010256;protein localization to Golgi apparatus#GO:0034067;cellular localization#GO:0051641;cellular component organization or biogenesis#GO:0071840;localization#GO:0051179;intracellular protein localization#GO:0008104 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;vesicle tethering complex#GO:0099023;membrane-bounded organelle#GO:0043227;COG complex#GO:0017119;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794 HUMAN|HGNC=29561|UniProtKB=Q9H2C2 Q9H2C2 ARV1 PTHR14467:SF0 ARV1 PROTEIN ARV1 glycolipid metabolic process#GO:0006664;phospholipid biosynthetic process#GO:0008654;glycerolipid metabolic process#GO:0046486;GPI anchored protein biosynthesis#GO:0180046;liposaccharide metabolic process#GO:1903509;phospholipid metabolic process#GO:0006644;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;protein metabolic process#GO:0019538;organophosphate biosynthetic process#GO:0090407;glycolipid biosynthetic process#GO:0009247;lipid biosynthetic process#GO:0008610;gene expression#GO:0010467;protein maturation#GO:0051604;GPI anchor biosynthetic process#GO:0006506;glycerophospholipid metabolic process#GO:0006650;biosynthetic process#GO:0009058;organophosphate metabolic process#GO:0019637;glycerolipid biosynthetic process#GO:0045017;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;carbohydrate derivative biosynthetic process#GO:1901137;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;GPI anchor metabolic process#GO:0006505;glycerophospholipid biosynthetic process#GO:0046474 intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505 HUMAN|HGNC=9247|UniProtKB=O75145 O75145 PPFIA3 PTHR12587:SF4 LAR INTERACTING PROTEIN LIP -RELATED PROTEIN LIPRIN-ALPHA-3 structural molecule activity#GO:0005198;protein complex scaffold activity#GO:0140378 cell junction organization#GO:0034330;cellular component organization or biogenesis#GO:0071840;cellular component organization#GO:0016043;cellular process#GO:0009987;synapse organization#GO:0050808 presynapse#GO:0098793;presynaptic active zone#GO:0048786;cellular anatomical structure#GO:0110165;synapse#GO:0045202;cell junction#GO:0030054 scaffold/adaptor protein#PC00226 HUMAN|HGNC=8354|UniProtKB=O95007 O95007 OR6B1 PTHR26453:SF284 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 6B1 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 response to stimulus#GO:0050896;response to chemical#GO:0042221;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;detection of chemical stimulus#GO:0009593;system process#GO:0003008;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;sensory perception#GO:0007600;nervous system process#GO:0050877 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=23038|UniProtKB=Q9NUN5 Q9NUN5 LMBRD1 PTHR16130:SF3 LYSOSOMAL COBALAMIN TRANSPORTER-RELATED LYSOSOMAL COBALAMIN TRANSPORT ESCORT PROTEIN LMBD1 protein localization to organelle#GO:0033365;localization#GO:0051179;intracellular protein localization#GO:0008104;macromolecule localization#GO:0033036;protein localization to lysosome#GO:0061462;protein localization to vacuole#GO:0072665 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;lytic vacuole membrane#GO:0098852;lysosome#GO:0005764;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;lytic vacuole#GO:0000323;vacuolar membrane#GO:0005774;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;membrane#GO:0016020;lysosomal membrane#GO:0005765;vacuole#GO:0005773;cytoplasm#GO:0005737 transporter#PC00227 HUMAN|HGNC=23419|UniProtKB=Q96EK5 Q96EK5 KIFBP PTHR46321:SF1 KIF1-BINDING PROTEIN KIF-BINDING PROTEIN axonogenesis#GO:0007409;neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;neuron projection organization#GO:0106027;cell projection organization#GO:0030030;cell differentiation#GO:0030154;central nervous system development#GO:0007417;cell morphogenesis#GO:0000902;cell development#GO:0048468;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cell projection morphogenesis#GO:0048858;microtubule-based process#GO:0007017;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;cytoskeleton organization#GO:0007010;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;organelle organization#GO:0006996;neuron projection development#GO:0031175;cellular process#GO:0009987;anatomical structure development#GO:0048856;microtubule cytoskeleton organization#GO:0000226;system development#GO:0048731;cellular developmental process#GO:0048869;neurogenesis#GO:0022008;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;central nervous system neuron differentiation#GO:0021953;multicellular organismal process#GO:0032501;plasma membrane bounded cell projection organization#GO:0120036;axon development#GO:0061564 HUMAN|HGNC=33187|UniProtKB=Q6P582 Q6P582 MZT2A PTHR28578:SF2 MITOTIC-SPINDLE ORGANIZING PROTEIN 2A-RELATED MITOTIC-SPINDLE ORGANIZING PROTEIN 2A microtubule organizing center#GO:0005815;centrosome#GO:0005813;spindle#GO:0005819;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;microtubule cytoskeleton#GO:0015630;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232 HUMAN|HGNC=26055|UniProtKB=Q8N357 Q8N357 SLC35F6 PTHR13146:SF0 SOLUTE CARRIER FAMILY 35 MEMBER F6-RELATED SOLUTE CARRIER FAMILY 35 MEMBER F6 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane#GO:0016020 HUMAN|HGNC=16870|UniProtKB=Q14680 Q14680 MELK PTHR24343:SF121 SERINE/THREONINE KINASE MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE protein serine/threonine kinase activity#GO:0004674;non-membrane spanning protein tyrosine kinase activity#GO:0004715;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein tyrosine kinase activity#GO:0004713;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=23378|UniProtKB=Q5HYC2 Q5HYC2 BRD10 PTHR31095:SF3 RIKEN CDNA 9930021J03 GENE BROMODOMAIN CONTAINING 10 HUMAN|HGNC=29603|UniProtKB=Q9UBD0 Q9UBD0 HSFX1 PTHR10015:SF282 HEAT SHOCK TRANSCRIPTION FACTOR HEAT SHOCK TRANSCRIPTION FACTOR, X-LINKED winged helix/forkhead transcription factor#PC00246;gene-specific transcriptional regulator#PC00264;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=1771|UniProtKB=P24941 P24941 CDK2 PTHR24056:SF521 CELL DIVISION PROTEIN KINASE CYCLIN-DEPENDENT KINASE 2 catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;cyclin-dependent protein kinase activity#GO:0097472;cyclin-dependent protein serine/threonine kinase activity#GO:0004693;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 mitotic cell cycle phase transition#GO:0044772;telomere organization#GO:0032200;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;cell cycle#GO:0007049;regulation of cellular process#GO:0050794;cell cycle phase transition#GO:0044770;G2/M transition of mitotic cell cycle#GO:0000086;mitotic cell cycle#GO:0000278;DNA damage response#GO:0006974;telomere maintenance#GO:0000723;chromosome organization#GO:0051276;mitotic cell cycle process#GO:1903047;macromolecule metabolic process#GO:0043170;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;cellular response to stress#GO:0033554;cell cycle process#GO:0022402;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;signaling#GO:0023052;response to stimulus#GO:0050896;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;signal transduction#GO:0007165;cell cycle G2/M phase transition#GO:0044839;response to stress#GO:0006950;organelle organization#GO:0006996 membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554;intracellular anatomical structure#GO:0005622;protein kinase complex#GO:1902911;transferase complex, transferring phosphorus-containing groups#GO:0061695;transferase complex#GO:1990234;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cyclin-dependent protein kinase holoenzyme complex#GO:0000307;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 p53 pathway#P00059>Cdc2#P04634;p53 pathway#P00059>Cdk2#P04625;p53 pathway feedback loops 2#P04398>cdk2#P04653 HUMAN|HGNC=30778|UniProtKB=Q8WXI9 Q8WXI9 GATAD2B PTHR13455:SF4 TRANSCRIPTIONAL REPRESSOR P66-RELATED TRANSCRIPTIONAL REPRESSOR P66-BETA DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700 negative regulation of macromolecule metabolic process#GO:0010605;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892 organelle lumen#GO:0043233;chromosome#GO:0005694;SWI/SNF superfamily-type complex#GO:0070603;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle lumen#GO:0070013;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ATPase complex#GO:1904949;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;histone deacetylase complex#GO:0000118;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;chromatin#GO:0000785;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;transcription regulator complex#GO:0005667 DNA-binding transcription factor#PC00218 HUMAN|HGNC=30251|UniProtKB=Q13145 Q13145 BAMBI PTHR15505:SF1 RIIA DOMAIN-CONTAINING PROTEIN 1 BMP AND ACTIVIN MEMBRANE-BOUND INHIBITOR HOMOLOG TGF-beta signaling pathway#P00052>BAMBI#P01287 HUMAN|HGNC=8031|UniProtKB=P04629 P04629 NTRK1 PTHR24416:SF370 TYROSINE-PROTEIN KINASE RECEPTOR HIGH AFFINITY NERVE GROWTH FACTOR RECEPTOR transmembrane receptor protein kinase activity#GO:0019199;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;protein tyrosine kinase activity#GO:0004713;catalytic activity#GO:0003824;transmembrane receptor protein tyrosine kinase activity#GO:0004714;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;kinase activity#GO:0016301;transferase activity#GO:0016740;protein kinase activity#GO:0004672;protein binding#GO:0005515;phosphotransferase activity, alcohol group as acceptor#GO:0016773;growth factor binding#GO:0019838;transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488 animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cellular response to growth factor stimulus#GO:0071363;system development#GO:0048731;response to endogenous stimulus#GO:0009719;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;response to growth factor#GO:0070848;cell differentiation#GO:0030154;signaling#GO:0023052;cell surface receptor signaling pathway#GO:0007166;developmental process#GO:0032502;neuron differentiation#GO:0030182;cellular developmental process#GO:0048869;cellular response to nerve growth factor stimulus#GO:1990090;multicellular organism development#GO:0007275;neurogenesis#GO:0022008;cellular process#GO:0009987;signal transduction#GO:0007165;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;biological regulation#GO:0065007 plasma membrane#GO:0005886;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020;axon#GO:0030424;signaling receptor complex#GO:0043235 transmembrane signal receptor#PC00197 HUMAN|HGNC=15927|UniProtKB=Q9Y282 Q9Y282 ERGIC3 PTHR10984:SF85 ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 3 localization#GO:0051179;vesicle-mediated transport#GO:0016192;establishment of localization#GO:0051234;retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum#GO:0006890;Golgi vesicle transport#GO:0048193;transport#GO:0006810;cellular process#GO:0009987 membrane#GO:0016020;cytoplasm#GO:0005737;endomembrane system#GO:0012505;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;coated vesicle#GO:0030135;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;COPII-coated ER to Golgi transport vesicle#GO:0030134 HUMAN|HGNC=18036|UniProtKB=Q96A84 Q96A84 EMID1 PTHR15427:SF23 EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER EMI DOMAIN-CONTAINING PROTEIN 1 positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;positive regulation of cell adhesion#GO:0045785;positive regulation of cell-substrate adhesion#GO:0010811;biological regulation#GO:0065007;regulation of cell-substrate adhesion#GO:0010810;regulation of cell adhesion#GO:0030155;regulation of cellular process#GO:0050794 scaffold/adaptor protein#PC00226 HUMAN|HGNC=18992|UniProtKB=Q8IZF6 Q8IZF6 ADGRG4 PTHR12011:SF277 ADHESION G-PROTEIN COUPLED RECEPTOR ADHESION G PROTEIN-COUPLED RECEPTOR G4 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930 biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=12178|UniProtKB=A0A0K0K1G8 A0A0K0K1G8 TRBV10-2 PTHR23268:SF42 T-CELL RECEPTOR BETA CHAIN T CELL RECEPTOR BETA VARIABLE 10-1-RELATED signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=31454|UniProtKB=Q6A555 Q6A555 TXNDC8 PTHR10438:SF230 THIOREDOXIN THIOREDOXIN DOMAIN-CONTAINING PROTEIN 8 catalytic activity#GO:0003824;oxidoreductase activity, acting on a sulfur group of donors#GO:0016667;protein-disulfide reductase activity#GO:0015035;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491;disulfide oxidoreductase activity#GO:0015036 sexual reproduction#GO:0019953;spermatogenesis#GO:0007283;developmental process#GO:0032502;cell redox homeostasis#GO:0045454;cellular homeostasis#GO:0019725;multicellular organismal reproductive process#GO:0048609;developmental process involved in reproduction#GO:0003006;homeostatic process#GO:0042592;reproductive process#GO:0022414;male gamete generation#GO:0048232;gamete generation#GO:0007276 nucleus#GO:0005634;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 metabolite interconversion enzyme#PC00262;oxidoreductase#PC00176 HUMAN|HGNC=13639|UniProtKB=O95231 O95231 VENTX PTHR24327:SF29 HOMEOBOX PROTEIN HOMEOBOX PROTEIN VENTX sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=5|UniProtKB=P04217 P04217 A1BG PTHR11738:SF184 MHC CLASS I NK CELL RECEPTOR ALPHA-1B-GLYCOPROTEIN molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888 cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;cellular process#GO:0009987;response to hormone#GO:0009725;biological regulation#GO:0065007;response to peptide hormone#GO:0043434;response to chemical#GO:0042221;cellular response to nitrogen compound#GO:1901699;cell surface receptor signaling pathway#GO:0007166;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to endogenous stimulus#GO:0009719;signaling#GO:0023052;cellular response to peptide hormone stimulus#GO:0071375;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;regulation of cellular process#GO:0050794;cellular response to hormone stimulus#GO:0032870;response to oxygen-containing compound#GO:1901700;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cellular response to chemical stimulus#GO:0070887;response to nitrogen compound#GO:1901698;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=29326|UniProtKB=Q8TBB6 Q8TBB6 SLC7A14 PTHR43243:SF17 INNER MEMBRANE TRANSPORTER YGJI-RELATED SOLUTE CARRIER FAMILY 7 MEMBER 14 amino acid transmembrane transporter activity#GO:0015171;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 localization#GO:0051179;establishment of localization#GO:0051234;transport#GO:0006810;amino acid transport#GO:0006865 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 secondary carrier transporter#PC00258;amino acid transporter#PC00046 HUMAN|HGNC=13870|UniProtKB=O43809 O43809 NUDT21 PTHR13047:SF0 PRE-MRNA CLEAVAGE FACTOR IM, 25KD SUBUNIT CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 5 mRNA binding#GO:0003729;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA 3'-UTR binding#GO:0003730;RNA binding#GO:0003723 mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;mRNA cleavage factor complex#GO:0005849;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226 RNA splicing factor#PC00148 HUMAN|HGNC=12921|UniProtKB=P52743 P52743 ZNF137P PTHR24377:SF649 IP01015P-RELATED ZINC FINGER PROTEIN 415-RELATED transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=25624|UniProtKB=Q8N5T2 Q8N5T2 TBC1D19 PTHR16110:SF1 TBC1 DOMAIN FAMILY MEMBER 19 TBC1 DOMAIN FAMILY MEMBER 19 HUMAN|HGNC=13714|UniProtKB=Q9NP86 Q9NP86 CABP5 PTHR45917:SF3 CALCIUM-BINDING PROTEIN 1-RELATED CALCIUM-BINDING PROTEIN 5 calcium channel regulator activity#GO:0005246;ion channel regulator activity#GO:0099106;transporter regulator activity#GO:0141108;molecular function regulator activity#GO:0098772;channel regulator activity#GO:0016247 multicellular organismal process#GO:0032501;biological regulation#GO:0065007;detection of stimulus#GO:0051606;response to radiation#GO:0009314;cellular process#GO:0009987;signal transduction#GO:0007165;system process#GO:0003008;response to external stimulus#GO:0009605;regulation of cellular process#GO:0050794;response to light stimulus#GO:0009416;visual perception#GO:0007601;response to stimulus#GO:0050896;signaling#GO:0023052;sensory perception of light stimulus#GO:0050953;response to abiotic stimulus#GO:0009628;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cell communication#GO:0007154;nervous system process#GO:0050877;sensory perception#GO:0007600 HUMAN|HGNC=37442|UniProtKB=A0A1B0GV03 A0A1B0GV03 GOLGA6L7 PTHR23143:SF22 TRICHOHYALIN-RELATED GOLGIN SUBFAMILY A MEMBER 6-LIKE PROTEIN 7 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=5212|UniProtKB=P37058 P37058 HSD17B3 PTHR43899:SF7 RH59310P 17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 3 catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614 cellular process#GO:0009987;primary metabolic process#GO:0044238;steroid metabolic process#GO:0008202;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;steroid biosynthetic process#GO:0006694 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 Androgen/estrogene/progesterone biosynthesis#P02727>Estradiol 17beta-dehydrogenase#P02826 HUMAN|HGNC=12737|UniProtKB=Q96G27 Q96G27 WBP1 PTHR16209:SF5 VESICULAR, OVEREXPRESSED IN CANCER, PROSURVIVAL PROTEIN 1 WW DOMAIN-BINDING PROTEIN 1 HUMAN|HGNC=25193|UniProtKB=Q6ZWT7 Q6ZWT7 MBOAT2 PTHR13906:SF7 PORCUPINE MEMBRANE-BOUND GLYCEROPHOSPHOLIPID O-ACYLTRANSFERASE 2 acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824 phospholipid metabolic process#GO:0006644;glycerolipid metabolic process#GO:0046486;phosphatidylcholine metabolic process#GO:0046470;glycerophospholipid metabolic process#GO:0006650;cellular process#GO:0009987;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;organophosphate metabolic process#GO:0019637;lipid modification#GO:0030258;lipid metabolic process#GO:0006629;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;membrane#GO:0016020 acetyltransferase#PC00038 HUMAN|HGNC=19262|UniProtKB=O95428 O95428 PAPLN PTHR13723:SF281 ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE PAPILIN catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222 primary metabolic process#GO:0044238;cellular component organization#GO:0016043;cellular process#GO:0009987;proteolysis#GO:0006508;metabolic process#GO:0008152;extracellular structure organization#GO:0043062;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;extracellular matrix organization#GO:0030198;protein metabolic process#GO:0019538;external encapsulating structure organization#GO:0045229 extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 HUMAN|HGNC=1675|UniProtKB=P09693 P09693 CD3G PTHR10570:SF8 T-CELL SURFACE GLYCOPROTEIN CD3 GAMMA CHAIN / DELTA CHAIN T-CELL SURFACE GLYCOPROTEIN CD3 GAMMA CHAIN transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell surface receptor signaling pathway#GO:0007166;developmental process#GO:0032502;cellular developmental process#GO:0048869;cellular process#GO:0009987;signal transduction#GO:0007165;T cell differentiation#GO:0030217;biological regulation#GO:0065007;hemopoiesis#GO:0030097;multicellular organismal process#GO:0032501;lymphocyte activation#GO:0046649;cell activation#GO:0001775;lymphocyte differentiation#GO:0030098;immune system process#GO:0002376;anatomical structure development#GO:0048856;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;mononuclear cell differentiation#GO:1903131;regulation of biological process#GO:0050789;T cell activation#GO:0042110;leukocyte differentiation#GO:0002521;leukocyte activation#GO:0045321;cell development#GO:0048468;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cell differentiation#GO:0030154 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;plasma membrane#GO:0005886;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;side of membrane#GO:0098552;signaling receptor complex#GO:0043235;external side of plasma membrane#GO:0009897 immunoglobulin receptor superfamily#PC00124 T cell activation#P00053>CD3 gamma#P01317 HUMAN|HGNC=24724|UniProtKB=Q6PGQ7 Q6PGQ7 BORA PTHR14728:SF2 PROTEIN AURORA BOREALIS PROTEIN AURORA BOREALIS protein binding#GO:0005515;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;kinase binding#GO:0019900;binding#GO:0005488 regulation of biological process#GO:0050789;regulation of mitotic cell cycle#GO:0007346;regulation of organelle organization#GO:0033043;regulation of spindle organization#GO:0090224;regulation of cellular component organization#GO:0051128;regulation of cytoskeleton organization#GO:0051493;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of cell cycle process#GO:0010564;regulation of cell cycle#GO:0051726;regulation of nuclear division#GO:0051783;regulation of microtubule cytoskeleton organization#GO:0070507;regulation of microtubule-based process#GO:0032886;regulation of mitotic spindle organization#GO:0060236;regulation of mitotic nuclear division#GO:0007088 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 HUMAN|HGNC=26220|UniProtKB=Q9H611 Q9H611 PIF1 PTHR23274:SF11 DNA HELICASE-RELATED ATP-DEPENDENT DNA HELICASE PIF1 macromolecular conformation isomerase activity#GO:0120543;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545;isomerase activity#GO:0016853;DNA helicase activity#GO:0003678;helicase activity#GO:0004386;catalytic activity, acting on DNA#GO:0140097;ATP-dependent activity#GO:0140657;ATP-dependent activity, acting on DNA#GO:0008094 DNA helicase#PC00011 HUMAN|HGNC=44407|UniProtKB=I6L899 I6L899 GOLGA8R PTHR10881:SF62 GOLGIN SUBFAMILY A MEMBER-RELATED GOLGIN SUBFAMILY A CONSERVED DOMAIN-CONTAINING PROTEIN-RELATED cellular component organization or biogenesis#GO:0071840;endomembrane system organization#GO:0010256;organelle organization#GO:0006996;cellular component organization#GO:0016043;Golgi organization#GO:0007030;cellular process#GO:0009987 Golgi apparatus subcompartment#GO:0098791;membrane#GO:0016020;endomembrane system#GO:0012505;Golgi cisterna#GO:0031985;cytoplasm#GO:0005737;Golgi cis cisterna#GO:0000137;Golgi apparatus#GO:0005794;organelle membrane#GO:0031090;cis-Golgi network#GO:0005801;Golgi stack#GO:0005795;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984 membrane traffic protein#PC00150 HUMAN|HGNC=11761|UniProtKB=P48307 P48307 TFPI2 PTHR10083:SF352 KUNITZ-TYPE PROTEASE INHIBITOR-RELATED TISSUE FACTOR PATHWAY INHIBITOR 2 endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414;peptidase regulator activity#GO:0061134;enzyme regulator activity#GO:0030234;serine-type endopeptidase inhibitor activity#GO:0004867;molecular function inhibitor activity#GO:0140678;enzyme inhibitor activity#GO:0004857;endopeptidase inhibitor activity#GO:0004866;molecular function regulator activity#GO:0098772 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protein-binding activity modulator#PC00095;protease inhibitor#PC00191 HUMAN|HGNC=17865|UniProtKB=Q96A26 Q96A26 FAM162A PTHR13674:SF2 GROWTH AND TRANSFORMATION-DEPENDENT PROTEIN PROTEIN FAM162A response to stress#GO:0006950;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;response to chemical#GO:0042221;biological regulation#GO:0065007;response to hypoxia#GO:0001666;response to abiotic stimulus#GO:0009628;cellular response to hypoxia#GO:0071456;programmed cell death#GO:0012501;response to decreased oxygen levels#GO:0036293;response to oxygen levels#GO:0070482;regulation of organelle organization#GO:0033043;cell death#GO:0008219;cellular response to stimulus#GO:0051716;apoptotic process#GO:0006915;regulation of mitochondrion organization#GO:0010821;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of cellular component organization#GO:0051128;regulation of release of cytochrome c from mitochondria#GO:0090199;cellular response to chemical stimulus#GO:0070887;positive regulation of cellular component organization#GO:0051130;cellular response to stress#GO:0033554;positive regulation of organelle organization#GO:0010638;neuron apoptotic process#GO:0051402 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739 HUMAN|HGNC=12530|UniProtKB=P22309 P22309 UGT1A1 PTHR48050:SF8 STEROL 3-BETA-GLUCOSYLTRANSFERASE UDP-GLUCURONOSYLTRANSFERASE 1A1 glycosyltransferase activity#GO:0016757;UDP-glycosyltransferase activity#GO:0008194;molecular function regulator activity#GO:0098772;catalytic activity#GO:0003824;transferase activity#GO:0016740;enzyme inhibitor activity#GO:0004857;protein binding#GO:0005515;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;binding#GO:0005488;enzyme binding#GO:0019899 response to chemical#GO:0042221;cellular response to lipid#GO:0071396;response to lipid#GO:0033993;steroid metabolic process#GO:0008202;response to hormone#GO:0009725;cellular process#GO:0009987;multicellular organism development#GO:0007275;animal organ development#GO:0048513;cellular response to steroid hormone stimulus#GO:0071383;metabolic process#GO:0008152;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;liver development#GO:0001889;cellular response to hormone stimulus#GO:0032870;response to endogenous stimulus#GO:0009719;regulation of hormone levels#GO:0010817;estrogen metabolic process#GO:0008210;regulation of biological quality#GO:0065008;cellular response to chemical stimulus#GO:0070887;animal gross anatomical part developmental process#GO:0160108;hormone metabolic process#GO:0042445;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;pigment metabolic process#GO:0042440;sterol metabolic process#GO:0016125;developmental process#GO:0032502;lipid metabolic process#GO:0006629;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;anatomical structure development#GO:0048856;system development#GO:0048731;response to steroid hormone#GO:0048545 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 transferase#PC00220;glycosyltransferase#PC00111 HUMAN|HGNC=30704|UniProtKB=Q96KD3 Q96KD3 GARIN1B PTHR22574:SF13 FAMILY NOT NAMED GOLGI-ASSOCIATED RAB2 INTERACTOR PROTEIN 1B HUMAN|HGNC=11301|UniProtKB=P61011 P61011 SRP54 PTHR11564:SF40 SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54 SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54 pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817;signal sequence receptor activity#GO:0005048;ribonucleoside triphosphate phosphatase activity#GO:0017111;GTPase activity#GO:0003924;binding#GO:0005488;nucleic acid binding#GO:0003676;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;RNA binding#GO:0003723;hydrolase activity#GO:0016787 protein targeting#GO:0006605;cellular localization#GO:0051641;transmembrane transport#GO:0055085;localization#GO:0051179;protein transport#GO:0015031;localization within membrane#GO:0051668;establishment of protein localization to endoplasmic reticulum#GO:0072599;establishment of protein localization to membrane#GO:0090150;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;establishment of localization#GO:0051234;intracellular protein transmembrane transport#GO:0065002;establishment of protein localization to organelle#GO:0072594;protein targeting to ER#GO:0045047;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;protein targeting to membrane#GO:0006612;protein transmembrane transport#GO:0071806;intracellular protein transport#GO:0006886;SRP-dependent cotranslational protein targeting to membrane#GO:0006614;transport#GO:0006810 ribonucleoprotein complex#GO:1990904;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;signal recognition particle, endoplasmic reticulum targeting#GO:0005786;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031 HUMAN|HGNC=24340|UniProtKB=Q5VZE5 Q5VZE5 NAA35 PTHR21373:SF1 GLUCOSE REPRESSIBLE PROTEIN MAK10 N-ALPHA-ACETYLTRANSFERASE 35, NATC AUXILIARY SUBUNIT biological regulation#GO:0065007;regulation of cellular process#GO:0050794;negative regulation of apoptotic process#GO:0043066;negative regulation of programmed cell death#GO:0043069;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of programmed cell death#GO:0043067;regulation of apoptotic process#GO:0042981;negative regulation of cellular process#GO:0048523 protein acetyltransferase complex#GO:0031248;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;acetyltransferase complex#GO:1902493;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737 acetyltransferase#PC00038 HUMAN|HGNC=30380|UniProtKB=Q9NV70 Q9NV70 EXOC1 PTHR16092:SF33 SEC3/SYNTAXIN-RELATED EXOCYST COMPLEX COMPONENT 1 phosphatidylinositol bisphosphate binding#GO:1902936;lipid binding#GO:0008289;phosphatidylinositol-4,5-bisphosphate binding#GO:0005546;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094;anion binding#GO:0043168;phosphatidylinositol phosphate binding#GO:1901981;phospholipid binding#GO:0005543 export from cell#GO:0140352;vesicle-mediated transport#GO:0016192;Golgi to plasma membrane transport#GO:0006893;cellular process#GO:0009987;secretion by cell#GO:0032940;exocytosis#GO:0006887;post-Golgi vesicle-mediated transport#GO:0006892;vesicle-mediated transport to the plasma membrane#GO:0098876;secretion#GO:0046903;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;Golgi vesicle transport#GO:0048193;transport#GO:0006810;localization within membrane#GO:0051668 intracellular anatomical structure#GO:0005622;vesicle tethering complex#GO:0099023;membrane#GO:0016020;cell periphery#GO:0071944;cell cortex#GO:0005938;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;exocyst#GO:0000145;cytoplasm#GO:0005737;plasma membrane#GO:0005886 SNARE protein#PC00034;membrane traffic protein#PC00150 HUMAN|HGNC=27288|UniProtKB=Q4G176 Q4G176 ACSF3 PTHR24096:SF435 LONG-CHAIN-FATTY-ACID--COA LIGASE MALONATE--COA LIGASE ACSF3, MITOCHONDRIAL ligase activity#GO:0016874;ligase activity, forming carbon-sulfur bonds#GO:0016877;catalytic activity#GO:0003824 monocarboxylic acid biosynthetic process#GO:0072330;lipid metabolic process#GO:0006629;small molecule biosynthetic process#GO:0044283;fatty acid metabolic process#GO:0006631;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;fatty acid biosynthetic process#GO:0006633;biosynthetic process#GO:0009058;lipid biosynthetic process#GO:0008610;small molecule metabolic process#GO:0044281;cellular process#GO:0009987;carboxylic acid biosynthetic process#GO:0046394;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226 ligase#PC00142 HUMAN|HGNC=12932|UniProtKB=Q14258 Q14258 TRIM25 PTHR25465:SF77 B-BOX DOMAIN CONTAINING E3 UBIQUITIN_ISG15 LIGASE TRIM25 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=20615|UniProtKB=Q50KZ9 Q50KZ9 TAS2R2 PTHR11394:SF57 TASTE RECEPTOR TYPE 2 TASTE RECEPTOR TYPE 2 MEMBER 2 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;taste receptor activity#GO:0008527;bitter taste receptor activity#GO:0033038;molecular transducer activity#GO:0060089 sensory perception of bitter taste#GO:0050913;detection of chemical stimulus#GO:0009593;detection of stimulus#GO:0051606;detection of stimulus involved in sensory perception#GO:0050906;response to chemical#GO:0042221;response to stimulus#GO:0050896;multicellular organismal process#GO:0032501;sensory perception#GO:0007600;nervous system process#GO:0050877;detection of chemical stimulus involved in sensory perception of taste#GO:0050912;sensory perception of taste#GO:0050909;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008;detection of chemical stimulus involved in sensory perception of bitter taste#GO:0001580 membrane#GO:0016020;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=6368|UniProtKB=P49862 P49862 KLK7 PTHR24271:SF45 KALLIKREIN-RELATED KALLIKREIN-7 hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171;serine-type peptidase activity#GO:0008236;catalytic activity, acting on a protein#GO:0140096;serine-type endopeptidase activity#GO:0004252;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;catalytic activity#GO:0003824 metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;secretory vesicle#GO:0099503;intracellular vesicle#GO:0097708;vesicle#GO:0031982;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;secretory granule#GO:0030141;membrane-bounded organelle#GO:0043227;extracellular region#GO:0005576;intracellular organelle#GO:0043229 serine protease#PC00203 HUMAN|HGNC=21071|UniProtKB=Q6PHW0 Q6PHW0 IYD PTHR23026:SF128 NADPH NITROREDUCTASE IODOTYROSINE DEIODINASE 1 catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 biological regulation#GO:0065007;hormone metabolic process#GO:0042445;regulation of hormone levels#GO:0010817;cellular process#GO:0009987;phenol-containing compound metabolic process#GO:0018958;modified amino acid metabolic process#GO:0006575;regulation of biological quality#GO:0065008;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 reductase#PC00198;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=18656|UniProtKB=Q9BRS2 Q9BRS2 RIOK1 PTHR45723:SF5 SERINE/THREONINE-PROTEIN KINASE RIO1 SERINE_THREONINE-PROTEIN KINASE RIO1 catalytic activity, acting on a protein#GO:0140096;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674 RNA metabolic process#GO:0016070;rRNA processing#GO:0006364;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;ribosomal small subunit biogenesis#GO:0042274;gene expression#GO:0010467;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;maturation of SSU-rRNA#GO:0030490;cellular component biogenesis#GO:0044085;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987 ribonucleoprotein complex#GO:1990904;cytosol#GO:0005829;preribosome#GO:0030684;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167;protein modifying enzyme#PC00260 HUMAN|HGNC=24185|UniProtKB=P46736 P46736 BRCC3 PTHR10410:SF34 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED LYS-63-SPECIFIC DEUBIQUITINASE BRCC36 catalytic activity#GO:0003824;metallopeptidase activity#GO:0008237;deubiquitinase activity#GO:0101005;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783 DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;macromolecule metabolic process#GO:0043170;double-strand break repair#GO:0006302;response to stress#GO:0006950;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139 organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 translation factor#PC00223;translation initiation factor#PC00224 HUMAN|HGNC=18906|UniProtKB=P0C7H8 P0C7H8 KRTAP2-3 PTHR23262:SF7 KERATIN ASSOCIATED PROTEIN KERATIN-ASSOCIATED PROTEIN 2-2-RELATED structural protein#PC00211 HUMAN|HGNC=33745|UniProtKB=Q6URK8 Q6URK8 SPMIP8 PTHR35348:SF1 TESTIS, PROSTATE AND PLACENTA-EXPRESSED PROTEIN SPERM MICROTUBULE INNER PROTEIN 8 cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;organelle#GO:0043226;axonemal microtubule#GO:0005879;cellular anatomical structure#GO:0110165;cytoplasmic microtubule#GO:0005881;supramolecular fiber#GO:0099512;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;microtubule#GO:0005874;axoneme#GO:0005930;intracellular organelle#GO:0043229;cilium#GO:0005929;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;axonemal doublet microtubule#GO:0097545;supramolecular complex#GO:0099080;ciliary plasm#GO:0097014;supramolecular polymer#GO:0099081;microtubule cytoskeleton#GO:0015630;A axonemal microtubule#GO:0097649;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;cytoskeleton#GO:0005856 HUMAN|HGNC=23475|UniProtKB=Q8N5W8 Q8N5W8 FAM24B PTHR35860:SF5 PROTEIN FAM24B PROTEIN FAM24B HUMAN|HGNC=26462|UniProtKB=Q0VAA5 Q0VAA5 PLCXD2 PTHR13593:SF32 FAMILY NOT NAMED PI-PLC X DOMAIN-CONTAINING PROTEIN 2 hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;phosphoric ester hydrolase activity#GO:0042578;hydrolase activity#GO:0016787;phosphoric diester hydrolase activity#GO:0008081 HUMAN|HGNC=321|UniProtKB=P35573 P35573 AGL PTHR10569:SF2 GLYCOGEN DEBRANCHING ENZYME GLYCOGEN DEBRANCHING ENZYME alpha-glucosidase activity#GO:0090599;hydrolase activity, acting on glycosyl bonds#GO:0016798;glycosyltransferase activity#GO:0016757;catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758;hydrolase activity, hydrolyzing O-glycosyl compounds#GO:0004553;hydrolase activity#GO:0016787;glucosidase activity#GO:0015926 carbohydrate metabolic process#GO:0005975;glucan catabolic process#GO:0009251;catabolic process#GO:0009056;polysaccharide metabolic process#GO:0005976;polysaccharide catabolic process#GO:0000272;glycogen metabolic process#GO:0005977;primary metabolic process#GO:0044238;glucan metabolic process#GO:0044042;carbohydrate catabolic process#GO:0016052;energy reserve metabolic process#GO:0006112;cellular process#GO:0009987;glycogen catabolic process#GO:0005980;macromolecule metabolic process#GO:0043170;energy derivation by oxidation of organic compounds#GO:0015980;generation of precursor metabolites and energy#GO:0006091;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057 HUMAN|HGNC=25989|UniProtKB=Q9NXE8 Q9NXE8 CWC25 PTHR16196:SF0 CELL CYCLE CONTROL PROTEIN CWF25 PRE-MRNA-SPLICING FACTOR CWC25 HOMOLOG mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA splicing#GO:0008380 ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;spliceosomal complex#GO:0005681;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;intracellular membrane-bounded organelle#GO:0043231;U2-type spliceosomal complex#GO:0005684 HUMAN|HGNC=10822|UniProtKB=P55822 P55822 SH3BGR PTHR12232:SF1 SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH PROTEIN molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674 HUMAN|HGNC=4223|UniProtKB=O14793 O14793 MSTN PTHR11848:SF278 TGF-BETA FAMILY GROWTH_DIFFERENTIATION FACTOR 8 receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;cytokine activity#GO:0005125;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;molecular function activator activity#GO:0140677 biological regulation#GO:0065007;tissue development#GO:0009888;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;cellular process#GO:0009987;skeletal muscle tissue development#GO:0007519;signal transduction#GO:0007165;transforming growth factor beta receptor signaling pathway#GO:0007179;animal organ development#GO:0048513;cell surface receptor signaling pathway#GO:0007166;striated muscle tissue development#GO:0014706;developmental process#GO:0032502;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;muscle organ development#GO:0007517;signaling#GO:0023052;muscle structure development#GO:0061061;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;response to growth factor#GO:0070848;cellular response to stimulus#GO:0051716;cellular response to transforming growth factor beta stimulus#GO:0071560;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;cellular response to growth factor stimulus#GO:0071363;muscle tissue development#GO:0060537;anatomical structure development#GO:0048856;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;response to transforming growth factor beta#GO:0071559;skeletal muscle organ development#GO:0060538;animal gross anatomical part developmental process#GO:0160108 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 growth factor#PC00112 TGF-beta signaling pathway#P00052>TGFbeta#P01286 HUMAN|HGNC=41910|UniProtKB=P0CW27 P0CW27 CCDC166 PTHR14845:SF4 COILED-COIL DOMAIN-CONTAINING 166 COILED-COIL DOMAIN-CONTAINING PROTEIN 166 HUMAN|HGNC=31940|UniProtKB=P0C7N8 P0C7N8 OR9G9 PTHR24242:SF158 G-PROTEIN COUPLED RECEPTOR OLFACTORY RECEPTOR 9G1-RELATED G-protein coupled receptor#PC00021 HUMAN|HGNC=20113|UniProtKB=Q6QHC5 Q6QHC5 DEGS2 PTHR12879:SF21 SPHINGOLIPID DELTA 4 DESATURASE/C-4 HYDROXYLASE PROTEIN DES2 SPHINGOLIPID DELTA(4)-DESATURASE_C4-MONOOXYGENASE DES2 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 primary metabolic process#GO:0044238;cellular process#GO:0009987;lipid biosynthetic process#GO:0008610;small molecule metabolic process#GO:0044281;biosynthetic process#GO:0009058;alcohol metabolic process#GO:0006066;sphingolipid biosynthetic process#GO:0030148;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;lipid metabolic process#GO:0006629;ceramide biosynthetic process#GO:0046513;ceramide metabolic process#GO:0006672 hydroxylase#PC00122;oxidoreductase#PC00176 HUMAN|HGNC=16921|UniProtKB=Q99490 Q99490 AGAP2 PTHR45819:SF3 CENTAURIN-GAMMA-1A ARF-GAP WITH GTPASE, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 2 enzyme regulator activity#GO:0030234;hydrolase activity#GO:0016787;molecular function activator activity#GO:0140677;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;GTPase activity#GO:0003924;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;ribonucleoside triphosphate phosphatase activity#GO:0017111;molecular function regulator activity#GO:0098772;catalytic activity#GO:0003824;enzyme activator activity#GO:0008047;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817 regulation of apoptotic process#GO:0042981;negative regulation of cellular process#GO:0048523;regulation of biological process#GO:0050789;negative regulation of programmed cell death#GO:0043069;negative regulation of biological process#GO:0048519;regulation of neuron apoptotic process#GO:0043523;regulation of programmed cell death#GO:0043067;negative regulation of neuron apoptotic process#GO:0043524;biological regulation#GO:0065007;negative regulation of apoptotic process#GO:0043066;regulation of cellular process#GO:0050794 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 GTPase-activating protein#PC00257;G-protein modulator#PC00022 HUMAN|HGNC=9774|UniProtKB=Q15286 Q15286 RAB35 PTHR47977:SF76 RAS-RELATED PROTEIN RAB RAS-RELATED PROTEIN RAB-35 nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;ion binding#GO:0043167;GTPase activity#GO:0003924;anion binding#GO:0043168;small molecule binding#GO:0036094;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;nucleoside phosphate binding#GO:1901265;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;guanyl nucleotide binding#GO:0019001 intracellular transport#GO:0046907;localization within membrane#GO:0051668;transport#GO:0006810;localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;endosomal transport#GO:0016197;vesicle-mediated transport to the plasma membrane#GO:0098876;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;endocytic recycling#GO:0032456;vesicle-mediated transport#GO:0016192 organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;plasma membrane#GO:0005886;membrane#GO:0016020;vesicle membrane#GO:0012506;cell periphery#GO:0071944;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endosome membrane#GO:0010008;endosome#GO:0005768;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982 small GTPase#PC00208 HUMAN|HGNC=11281|UniProtKB=Q9HD15 Q9HD15 SRA1 PTHR18834:SF2 STEROID RECEPTOR RNA ACTIVATOR 1 STEROID RECEPTOR RNA ACTIVATOR 1 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription coactivator activity#GO:0003713 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=1365|UniProtKB=Q9UGQ2 Q9UGQ2 CACFD1 PTHR13314:SF2 CALCIUM CHANNEL FLOWER HOMOLOG CALCIUM CHANNEL FLOWER HOMOLOG transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;calcium channel activity#GO:0005262;passive transmembrane transporter activity#GO:0022803;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic cation channel activity#GO:0005261;calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267 metal ion transport#GO:0030001;endocytosis#GO:0006897;calcium ion transmembrane transport#GO:0070588;synaptic vesicle endocytosis#GO:0048488;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;cellular localization#GO:0051641;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;synaptic vesicle recycling#GO:0036465;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;calcium ion transport#GO:0006816;import into cell#GO:0098657;establishment of localization#GO:0051234;vesicle-mediated transport in synapse#GO:0099003;transport#GO:0006810;synaptic vesicle cycle#GO:0099504 intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;exocytic vesicle#GO:0070382;intracellular organelle#GO:0043229;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;synaptic vesicle#GO:0008021;vesicle#GO:0031982;synaptic vesicle membrane#GO:0030672;cell junction#GO:0030054;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;transport vesicle membrane#GO:0030658;transport vesicle#GO:0030133;cytoplasm#GO:0005737;plasma membrane#GO:0005886;secretory vesicle#GO:0099503;membrane#GO:0016020;vesicle membrane#GO:0012506;cell periphery#GO:0071944;presynapse#GO:0098793 HUMAN|HGNC=10526|UniProtKB=Q9Y467 Q9Y467 SALL2 PTHR23233:SF15 SAL-LIKE PROTEIN SAL-LIKE PROTEIN 2 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244;DNA-binding transcription factor#PC00218 HUMAN|HGNC=6053|UniProtKB=P12268 P12268 IMPDH2 PTHR11911:SF121 INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE 2 oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on CH-OH group of donors#GO:0016614;catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor#GO:0016616 ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;ribose phosphate biosynthetic process#GO:0046390;nucleobase-containing small molecule metabolic process#GO:0055086;ribonucleoside triphosphate biosynthetic process#GO:0009201;carbohydrate derivative biosynthetic process#GO:1901137;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;small molecule metabolic process#GO:0044281;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;phosphorus metabolic process#GO:0006793;nucleotide biosynthetic process#GO:0009165;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide metabolic process#GO:0009117;ribonucleotide metabolic process#GO:0009259;purine-containing compound biosynthetic process#GO:0072522;purine nucleotide biosynthetic process#GO:0006164;purine ribonucleoside triphosphate biosynthetic process#GO:0009206;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;purine ribonucleoside triphosphate metabolic process#GO:0009205;carbohydrate derivative metabolic process#GO:1901135;nucleoside triphosphate biosynthetic process#GO:0009142;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;nucleoside phosphate biosynthetic process#GO:1901293;nucleoside phosphate metabolic process#GO:0006753;nucleoside triphosphate metabolic process#GO:0009141;purine nucleoside triphosphate biosynthetic process#GO:0009145;purine nucleoside triphosphate metabolic process#GO:0009144;primary metabolic process#GO:0044238;organophosphate biosynthetic process#GO:0090407 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 dehydrogenase#PC00092 De novo purine biosynthesis#P02738>IMP dehydrogenase#P02895 HUMAN|HGNC=12457|UniProtKB=Q16222 Q16222 UAP1 PTHR11952:SF4 UDP- GLUCOSE PYROPHOSPHORYLASE UDP-N-ACETYLHEXOSAMINE PYROPHOSPHORYLASE catalytic activity#GO:0003824;transferase activity#GO:0016740;nucleotidyltransferase activity#GO:0016779;transferase activity, transferring phosphorus-containing groups#GO:0016772 primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;amino sugar metabolic process#GO:0006040;small molecule metabolic process#GO:0044281;nucleoside phosphate metabolic process#GO:0006753;UDP-N-acetylglucosamine biosynthetic process#GO:0006048;UDP-N-acetylglucosamine metabolic process#GO:0006047;organophosphate biosynthetic process#GO:0090407;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;nucleotide-sugar metabolic process#GO:0009225;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;carbohydrate derivative biosynthetic process#GO:1901137;nucleoside phosphate biosynthetic process#GO:1901293;nucleobase-containing small molecule metabolic process#GO:0055086 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cytosol#GO:0005829 HUMAN|HGNC=5542|UniProtKB=P38935 P38935 IGHMBP2 PTHR43788:SF20 DNA2/NAM7 HELICASE FAMILY MEMBER DNA-BINDING PROTEIN SMUBP-2 ATP-dependent activity, acting on DNA#GO:0008094;ATP-dependent activity#GO:0140657;isomerase activity#GO:0016853;DNA helicase activity#GO:0003678;catalytic activity, acting on DNA#GO:0140097;helicase activity#GO:0004386;macromolecular conformation isomerase activity#GO:0120543;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;nucleic acid conformation isomerase activity#GO:0120545 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cellular response to stress#GO:0033554;DNA damage response#GO:0006974;response to stress#GO:0006950;response to stimulus#GO:0050896 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 DNA metabolism protein#PC00009 HUMAN|HGNC=9876|UniProtKB=O14827 O14827 RASGRF2 PTHR23113:SF187 GUANINE NUCLEOTIDE EXCHANGE FACTOR RAS-SPECIFIC GUANINE NUCLEOTIDE-RELEASING FACTOR 2 enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;intracellular signaling cassette#GO:0141124;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;Ras protein signal transduction#GO:0007265;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=24144|UniProtKB=Q96A11 Q96A11 GAL3ST3 PTHR14647:SF83 GALACTOSE-3-O-SULFOTRANSFERASE GALACTOSE-3-O-SULFOTRANSFERASE 3 transferase activity#GO:0016740;catalytic activity#GO:0003824;sulfotransferase activity#GO:0008146;transferase activity, transferring sulphur-containing groups#GO:0016782 transferase#PC00220 HUMAN|HGNC=33|UniProtKB=Q99758 Q99758 ABCA3 PTHR19229:SF98 ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA PHOSPHOLIPID-TRANSPORTING ATPASE ABCA3 ATPase-coupled transmembrane transporter activity#GO:0042626;ATP-dependent activity#GO:0140657;lipid carrier activity#GO:0005319;molecular carrier activity#GO:0140104;primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 establishment of localization#GO:0051234;lipid transport#GO:0006869;localization#GO:0051179;macromolecule localization#GO:0033036;lipid localization#GO:0010876;transport#GO:0006810 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229 ATP-binding cassette (ABC) transporter#PC00003 HUMAN|HGNC=7593|UniProtKB=Q9HD67 Q9HD67 MYO10 PTHR46049:SF2 AGAP003327-PA UNCONVENTIONAL MYOSIN-X cytoskeletal protein binding#GO:0008092;phosphatidylinositol phosphate binding#GO:1901981;cytoskeletal motor activity#GO:0003774;actin binding#GO:0003779;ATP-dependent activity#GO:0140657;binding#GO:0005488;protein-containing complex binding#GO:0044877;lipid binding#GO:0008289;protein binding#GO:0005515;macromolecular conformation isomerase activity#GO:0120543;phospholipid binding#GO:0005543;catalytic activity#GO:0003824;microfilament motor activity#GO:0000146;isomerase activity#GO:0016853;actin filament binding#GO:0051015;anion binding#GO:0043168;small molecule binding#GO:0036094;polypeptide conformation or assembly isomerase activity#GO:0120544;ion binding#GO:0043167 regulation of cell shape#GO:0008360;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of plasma membrane bounded cell projection assembly#GO:0120032;regulation of cellular component organization#GO:0051128;regulation of cellular component biogenesis#GO:0044087;regulation of developmental process#GO:0050793;cellular localization#GO:0051641;localization#GO:0051179;regulation of biological quality#GO:0065008;regulation of cell projection assembly#GO:0060491;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;cytoskeleton-dependent intracellular transport#GO:0030705;biological regulation#GO:0065007;intracellular transport#GO:0046907;regulation of cell projection organization#GO:0031344;transport#GO:0006810;establishment of localization#GO:0051234;regulation of anatomical structure morphogenesis#GO:0022603;regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of filopodium assembly#GO:0051489 actin-based cell projection#GO:0098858;actin cytoskeleton#GO:0015629;plasma membrane bounded cell projection#GO:0120025;intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;filopodium#GO:0030175;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HUMAN|HGNC=12363|UniProtKB=P49815 P49815 TSC2 PTHR10063:SF0 TUBERIN TUBERIN molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;enzyme activator activity#GO:0008047 negative regulation of TORC1 signaling#GO:1904262;regulation of macroautophagy#GO:0016241;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of TOR signaling#GO:0032006;positive regulation of autophagy#GO:0010508;negative regulation of signal transduction#GO:0009968;intracellular signaling cassette#GO:0141124;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;negative regulation of cell communication#GO:0010648;positive regulation of metabolic process#GO:0009893;negative regulation of intracellular signal transduction#GO:1902532;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of autophagy#GO:0010506;signaling#GO:0023052;regulation of cell cycle#GO:0051726;positive regulation of macroautophagy#GO:0016239;response to stimulus#GO:0050896;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;regulation of TORC1 signaling#GO:1903432;regulation of catabolic process#GO:0009894;positive regulation of catabolic process#GO:0009896;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;small GTPase-mediated signal transduction#GO:0007264;negative regulation of response to stimulus#GO:0048585;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;regulation of cell communication#GO:0010646;negative regulation of TOR signaling#GO:0032007;regulation of cellular process#GO:0050794 cytosol#GO:0005829;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 GTPase-activating protein#PC00257;G-protein modulator#PC00022 p53 pathway by glucose deprivation#P04397>TSC2#P04644;p53 pathway by glucose deprivation#P04397>TSC2#G04706;Insulin/IGF pathway-protein kinase B signaling cascade#P00033>TSC2#P04494 HUMAN|HGNC=5785|UniProtKB=P06310 P06310 IGKV2-30 PTHR23267:SF536 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN KAPPA VARIABLE 2-30-RELATED immune system process#GO:0002376;immune response#GO:0006955;response to stimulus#GO:0050896 protein-containing complex#GO:0032991 immunoglobulin#PC00123;defense/immunity protein#PC00090 HUMAN|HGNC=14065|UniProtKB=Q9UKV0 Q9UKV0 HDAC9 PTHR10625:SF41 HISTONE DEACETYLASE HDAC1-RELATED HISTONE DEACETYLASE 9 histone deacetylase activity#GO:0004407;catalytic activity#GO:0003824;deacylase activity#GO:0160215;histone modifying activity#GO:0140993;deacetylase activity#GO:0019213;catalytic activity, acting on a protein#GO:0140096 regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;cellular component organization#GO:0016043;regulation of macromolecule biosynthetic process#GO:0010556;cellular process#GO:0009987;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;chromatin remodeling#GO:0006338;chromatin organization#GO:0006325;biological regulation#GO:0065007 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;nuclear protein-containing complex#GO:0140513;histone deacetylase complex#GO:0000118;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;cytoplasm#GO:0005737 HUMAN|HGNC=31041|UniProtKB=Q2MJR0 Q2MJR0 SPRED3 PTHR11202:SF19 SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN 3 protein binding#GO:0005515;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;kinase binding#GO:0019900;binding#GO:0005488 regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;negative regulation of biological process#GO:0048519;negative regulation of MAPK cascade#GO:0043409;regulation of biological process#GO:0050789;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;negative regulation of response to stimulus#GO:0048585;regulation of ERK1 and ERK2 cascade#GO:0070372;negative regulation of ERK1 and ERK2 cascade#GO:0070373;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;regulation of response to stimulus#GO:0048583;regulation of MAPK cascade#GO:0043408 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=9176|UniProtKB=P49005 P49005 POLD2 PTHR10416:SF0 DNA POLYMERASE DELTA SUBUNIT 2 DNA POLYMERASE DELTA SUBUNIT 2 enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234 DNA damage tolerance#GO:0006301;DNA damage response#GO:0006974;nucleobase-containing compound biosynthetic process#GO:0034654;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;DNA biosynthetic process#GO:0071897;response to stress#GO:0006950;translesion synthesis#GO:0019985;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;cellular response to stress#GO:0033554;nucleic acid biosynthetic process#GO:0141187;DNA synthesis involved in DNA replication#GO:0090592;DNA-templated DNA replication#GO:0006261;cellular response to stimulus#GO:0051716;DNA replication#GO:0006260;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;DNA strand elongation involved in DNA replication#GO:0006271;response to stimulus#GO:0050896 membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;DNA polymerase complex#GO:0042575;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;intracellular protein-containing complex#GO:0140535;chromosome#GO:0005694;organelle lumen#GO:0043233;replisome#GO:0030894;replication fork#GO:0005657;organelle#GO:0043226;protein-DNA complex#GO:0032993;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;nuclear replication fork#GO:0043596;intracellular organelle lumen#GO:0070013;transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 DNA-directed DNA polymerase#PC00018;DNA metabolism protein#PC00009 DNA replication#P00017>Pol delta#P00533 HUMAN|HGNC=9581|UniProtKB=Q9H939 Q9H939 PSTPIP2 PTHR23065:SF9 PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1 PROLINE-SERINE-THREONINE PHOSPHATASE-INTERACTING PROTEIN 2 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 actin or actin-binding cytoskeletal protein#PC00041;cytoskeletal protein#PC00085 HUMAN|HGNC=23820|UniProtKB=Q96AV8 Q96AV8 E2F7 PTHR12081:SF25 TRANSCRIPTION FACTOR E2F TRANSCRIPTION FACTOR E2F7 DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;intracellular anatomical structure#GO:0005622;RNA polymerase II transcription regulator complex#GO:0090575;nucleus#GO:0005634;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231 gene-specific transcriptional regulator#PC00264;winged helix/forkhead transcription factor#PC00246;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=21081|UniProtKB=Q8NI08 Q8NI08 NCOA7 PTHR23354:SF68 NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED NUCLEAR RECEPTOR COACTIVATOR 7 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;transcription coactivator activity#GO:0003713 regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;response to stress#GO:0006950;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;response to oxidative stress#GO:0006979;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=30437|UniProtKB=Q6ICH7 Q6ICH7 ASPHD2 PTHR46332:SF3 ASPARTATE BETA-HYDROXYLASE DOMAIN-CONTAINING PROTEIN 2 ASPARTATE BETA-HYDROXYLASE DOMAIN-CONTAINING PROTEIN 2 oxidoreductase#PC00176;hydroxylase#PC00122 HUMAN|HGNC=14268|UniProtKB=Q9HCL0 Q9HCL0 PCDH18 PTHR24028:SF9 CADHERIN-87A PROTOCADHERIN-18 cell adhesion#GO:0007155;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 cell adhesion molecule#PC00069;cadherin#PC00057 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HUMAN|HGNC=12611|UniProtKB=Q92995 Q92995 USP13 PTHR24006:SF682 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 13 deubiquitinase activity#GO:0101005;hydrolase activity#GO:0016787;cysteine-type peptidase activity#GO:0008234;cysteine-type deubiquitinase activity#GO:0004843;catalytic activity#GO:0003824;peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity, acting on a protein#GO:0140096 regulation of protein stability#GO:0031647;regulation of biological quality#GO:0065008;biological regulation#GO:0065007 nucleus#GO:0005634;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 protease#PC00190;cysteine protease#PC00081 HUMAN|HGNC=21625|UniProtKB=Q5XXA6 Q5XXA6 ANO1 PTHR12308:SF13 ANOCTAMIN ANOCTAMIN-1 molecular carrier activity#GO:0140104;gated channel activity#GO:0022836;chloride channel activity#GO:0005254;transporter activity#GO:0005215;monoatomic anion transmembrane transporter activity#GO:0008509;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;lipid carrier activity#GO:0005319;ligand-gated monoatomic ion channel activity#GO:0015276;phospholipid scramblase activity#GO:0017128;monoatomic anion channel activity#GO:0005253;intramembrane lipid carrier activity#GO:0140303;channel activity#GO:0015267;passive transmembrane transporter activity#GO:0022803;chloride transmembrane transporter activity#GO:0015108;ligand-gated channel activity#GO:0022834;transmembrane transporter activity#GO:0022857 lipid localization#GO:0010876;transmembrane transport#GO:0055085;chloride transmembrane transport#GO:1902476;localization#GO:0051179;regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;inorganic anion transport#GO:0015698;cellular component organization#GO:0016043;monoatomic anion transport#GO:0006820;organophosphate ester transport#GO:0015748;lipid translocation#GO:0034204;chloride transport#GO:0006821;transport#GO:0006810;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;regulation of membrane lipid distribution#GO:0097035;macromolecule localization#GO:0033036;cellular process#GO:0009987;monoatomic anion transmembrane transport#GO:0098656;lipid transport#GO:0006869;monoatomic ion transmembrane transport#GO:0034220;phospholipid transport#GO:0015914;membrane organization#GO:0061024;phospholipid translocation#GO:0045332;biological regulation#GO:0065007 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227;ion channel#PC00133 HUMAN|HGNC=18222|UniProtKB=Q9NWB1 Q9NWB1 RBFOX1 PTHR15597:SF52 ATAXIN 2-BINDING PROTEIN 1-RELATED RNA BINDING PROTEIN FOX-1 HOMOLOG 1 binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723 regulation of biological process#GO:0050789;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;animal gross anatomical part developmental process#GO:0160108;anatomical structure development#GO:0048856;system development#GO:0048731;regulation of alternative mRNA splicing, via spliceosome#GO:0000381;regulation of RNA metabolic process#GO:0051252;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of mRNA processing#GO:0050684;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007;nervous system development#GO:0007399;developmental process#GO:0032502;multicellular organism development#GO:0007275;regulation of biosynthetic process#GO:0009889;regulation of mRNA metabolic process#GO:1903311;regulation of gene expression#GO:0010468 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 RNA processing factor#PC00147;RNA splicing factor#PC00148 HUMAN|HGNC=1908|UniProtKB=Q96RL7 Q96RL7 VPS13A PTHR16166:SF22 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13 INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13A transporter activity#GO:0005215;molecular carrier activity#GO:0140104;lipid carrier activity#GO:0005319;lipid transfer activity#GO:0120013;phospholipid transfer activity#GO:0120014 autophagy#GO:0006914;cellular process#GO:0009987;organelle organization#GO:0006996;macromolecule localization#GO:0033036;mitochondrion organization#GO:0007005;membrane organization#GO:0061024;macroautophagy#GO:0016236;lipid transport#GO:0006869;transport#GO:0006810;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;intermembrane lipid transfer#GO:0120009;cellular component organization#GO:0016043;catabolic process#GO:0009056;lipid localization#GO:0010876;process utilizing autophagic mechanism#GO:0061919;localization#GO:0051179 organelle envelope#GO:0031967;intracellular vesicle#GO:0097708;mitochondrion#GO:0005739;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;endosome membrane#GO:0010008;endosome#GO:0005768;outer membrane#GO:0019867;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membrane#GO:0016020;vesicle membrane#GO:0012506;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;organelle outer membrane#GO:0031968;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;cytoplasm#GO:0005737;mitochondrial outer membrane#GO:0005741;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588 membrane traffic protein#PC00150 HUMAN|HGNC=24661|UniProtKB=Q96IC2 Q96IC2 REXO5 PTHR12801:SF82 RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED RNA EXONUCLEASE 5 hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;exonuclease activity#GO:0004527;catalytic activity, acting on a nucleic acid#GO:0140640;nuclease activity#GO:0004518;hydrolase activity#GO:0016787 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;RNA 3'-end processing#GO:0031123;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 RNA metabolism protein#PC00031;exoribonuclease#PC00099 HUMAN|HGNC=33434|UniProtKB=Q9Y6U7 Q9Y6U7 RNF215 PTHR22765:SF345 RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING RING FINGER PROTEIN 215 ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=19038|UniProtKB=Q86TW2 Q86TW2 ADCK1 PTHR43173:SF19 ABC1 FAMILY PROTEIN AARF DOMAIN-CONTAINING PROTEIN KINASE 1 chemical homeostasis#GO:0048878;cellular component organization or biogenesis#GO:0071840;organelle organization#GO:0006996;lipid homeostasis#GO:0055088;cellular component organization#GO:0016043;cellular process#GO:0009987;mitochondrion organization#GO:0007005;homeostatic process#GO:0042592 organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;membrane#GO:0016020;mitochondrial inner membrane#GO:0005743;organelle envelope#GO:0031967;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;organelle membrane#GO:0031090;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 transporter#PC00227;primary active transporter#PC00068;ATP-binding cassette (ABC) transporter#PC00003 HUMAN|HGNC=26316|UniProtKB=Q96LU7 Q96LU7 MYRFL PTHR13029:SF17 FAMILY NOT NAMED MYELIN REGULATORY FACTOR-LIKE PROTEIN sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;transcription regulator activity#GO:0140110;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biosynthetic process#GO:0009058;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;macromolecule biosynthetic process#GO:0009059;protein processing#GO:0016485;positive regulation of cellular process#GO:0048522;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;regulation of gene expression#GO:0010468;regulation of biological process#GO:0050789;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;proteolysis#GO:0006508;protein maturation#GO:0051604;gene expression#GO:0010467;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;metabolic process#GO:0008152 intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;organelle membrane#GO:0031090;membrane#GO:0016020;nucleus#GO:0005634;endomembrane system#GO:0012505;cytoplasm#GO:0005737 HUMAN|HGNC=33751|UniProtKB=Q5JS37 Q5JS37 NHLRC3 PTHR24104:SF31 E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED NHL REPEAT-CONTAINING PROTEIN 3 ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;catalytic activity, acting on a protein#GO:0140096;aminoacyltransferase activity#GO:0016755;transferase activity#GO:0016740;catalytic activity#GO:0003824 catabolic process#GO:0009056;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;protein polyubiquitination#GO:0000209;protein modification process#GO:0036211;primary metabolic process#GO:0044238;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein modification by small protein conjugation or removal#GO:0070647;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;proteasomal protein catabolic process#GO:0010498;cellular process#GO:0009987;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 Vasopressin synthesis#P04395>Amidating Enzyme#P04599 HUMAN|HGNC=13840|UniProtKB=P0CG08 P0CG08 GPHRB PTHR15948:SF8 G-PROTEIN COUPLED RECEPTOR 89-RELATED GOLGI PH REGULATOR A-RELATED monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;voltage-gated monoatomic anion channel activity#GO:0008308;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic anion transmembrane transporter activity#GO:0008509;passive transmembrane transporter activity#GO:0022803;channel activity#GO:0015267;voltage-gated channel activity#GO:0022832;monoatomic anion channel activity#GO:0005253;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244 regulation of biological quality#GO:0065008;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;regulation of pH#GO:0006885;chemical homeostasis#GO:0048878;intracellular monoatomic cation homeostasis#GO:0030003;monoatomic cation homeostasis#GO:0055080;regulation of intracellular pH#GO:0051453;homeostatic process#GO:0042592;biological regulation#GO:0065007;monoatomic ion homeostasis#GO:0050801;intracellular monoatomic ion homeostasis#GO:0006873 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;membrane#GO:0016020;cytoplasm#GO:0005737;endomembrane system#GO:0012505;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588 G-protein coupled receptor#PC00021 HUMAN|HGNC=25082|UniProtKB=Q8WU79 Q8WU79 SMAP2 PTHR45705:SF4 FI20236P1 STROMAL MEMBRANE-ASSOCIATED PROTEIN 2 enzyme activator activity#GO:0008047;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;enzyme regulator activity#GO:0030234 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=2351|UniProtKB=O75629 O75629 CREG1 PTHR13343:SF21 CREG1 PROTEIN PROTEIN CREG1 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=10934|UniProtKB=P54219 P54219 SLC18A1 PTHR23506:SF31 GH10249P CHROMAFFIN GRANULE AMINE TRANSPORTER active transmembrane transporter activity#GO:0022804;sodium ion transmembrane transporter activity#GO:0015081;solute:monoatomic cation symporter activity#GO:0015294;monoamine transmembrane transporter activity#GO:0008504;transmembrane transporter activity#GO:0022857;chloride transmembrane transporter activity#GO:0015108;solute:sodium symporter activity#GO:0015370;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;monoatomic anion transmembrane transporter activity#GO:0008509;secondary active transmembrane transporter activity#GO:0015291;antiporter activity#GO:0015297;proton transmembrane transporter activity#GO:0015078;monoatomic cation transmembrane transporter activity#GO:0008324;symporter activity#GO:0015293 localization#GO:0051179;establishment of localization#GO:0051234;cellular localization#GO:0051641;vesicle-mediated transport in synapse#GO:0099003;synaptic vesicle cycle#GO:0099504;transport#GO:0006810;neurotransmitter transport#GO:0006836;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;nitrogen compound transport#GO:0071705 cell projection#GO:0042995;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;intracellular vesicle#GO:0097708;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;cytoplasm#GO:0005737;cytoplasmic vesicle membrane#GO:0030659;neuron projection#GO:0043005;presynapse#GO:0098793;secretory vesicle#GO:0099503;bounding membrane of organelle#GO:0098588;cell junction#GO:0030054;neuron projection terminus#GO:0044306;intracellular membrane-bounded organelle#GO:0043231;plasma membrane bounded cell projection#GO:0120025;distal axon#GO:0150034;terminal bouton#GO:0043195;vesicle#GO:0031982;synaptic vesicle membrane#GO:0030672;synaptic vesicle#GO:0008021;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;axon#GO:0030424;transport vesicle#GO:0030133;endomembrane system#GO:0012505;transport vesicle membrane#GO:0030658;vesicle membrane#GO:0012506;membrane#GO:0016020;axon terminus#GO:0043679;organelle membrane#GO:0031090 transporter#PC00227;secondary carrier transporter#PC00258 5HT1 type receptor mediated signaling pathway#P04373>5HT vesicular transporter#P04410;5HT4 type receptor mediated signaling pathway#P04376>5HT vesicular transporter#P04432;Adrenaline and noradrenaline biosynthesis#P00001>VAT1#P00071;5HT3 type receptor mediated signaling pathway#P04375>5HT vesicular transporter#P04424;5HT2 type receptor mediated signaling pathway#P04374>5HT vesicular transporter#P04418 HUMAN|HGNC=6658|UniProtKB=O00534 O00534 VWA5A PTHR45737:SF6 VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A HUMAN|HGNC=29079|UniProtKB=O60341 O60341 KDM1A PTHR10742:SF423 FLAVIN MONOAMINE OXIDASE LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A histone demethylase activity#GO:0032452;protein demethylase activity#GO:0140457;heterocyclic compound binding#GO:1901363;demethylase activity#GO:0032451;nucleoside phosphate binding#GO:1901265;flavin adenine dinucleotide binding#GO:0050660;binding#GO:0005488;histone modifying activity#GO:0140993;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491;nucleotide binding#GO:0000166;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;chromatin binding#GO:0003682 regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;chromatin remodeling#GO:0006338;chromatin organization#GO:0006325;biological regulation#GO:0065007;epigenetic regulation of gene expression#GO:0040029;cellular component organization#GO:0016043;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;cellular process#GO:0009987;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;cellular component organization or biogenesis#GO:0071840;regulation of gene expression#GO:0010468 intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;chromatin#GO:0000785;nucleus#GO:0005634;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229 oxidase#PC00175 HUMAN|HGNC=29639|UniProtKB=Q9HAY2 Q9HAY2 MAGEF1 PTHR11736:SF61 MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN MELANOMA-ASSOCIATED ANTIGEN F1 negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 scaffold/adaptor protein#PC00226 HUMAN|HGNC=2529|UniProtKB=P07339 P07339 CTSD PTHR47966:SF42 BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED CATHEPSIN D catalytic activity#GO:0003824;aspartic-type endopeptidase activity#GO:0004190;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233 metabolic process#GO:0008152;proteolysis#GO:0006508;primary metabolic process#GO:0044238;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 lysosome#GO:0005764;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;vacuole#GO:0005773;extracellular region#GO:0005576;intracellular organelle#GO:0043229;lytic vacuole#GO:0000323;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 protease#PC00190;aspartic protease#PC00053 HUMAN|HGNC=4449|UniProtKB=P35052 P35052 GPC1 PTHR10822:SF8 GLYPICAN GLYPICAN-1 binding#GO:0005488;fibroblast growth factor binding#GO:0017134;protein binding#GO:0005515;growth factor binding#GO:0019838 regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;cell motility#GO:0048870;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of cell communication#GO:0010648;regulation of protein localization#GO:0032880;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;regulation of cellular response to growth factor stimulus#GO:0090287;regulation of fibroblast growth factor receptor signaling pathway#GO:0040036;biological regulation#GO:0065007;negative regulation of response to stimulus#GO:0048585;cell migration#GO:0016477;cellular process#GO:0009987;regulation of protein localization to membrane#GO:1905475;regulation of localization#GO:0032879;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523 cellular anatomical structure#GO:0110165;synapse#GO:0045202;cell surface#GO:0009986;cell junction#GO:0030054;extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 scaffold/adaptor protein#PC00226 HUMAN|HGNC=11566|UniProtKB=O15533 O15533 TAPBP PTHR23411:SF22 TAPASIN TAPASIN protein-containing complex binding#GO:0044877;binding#GO:0005488 antigen processing and presentation#GO:0019882;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;immune system process#GO:0002376;cellular component assembly#GO:0022607;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003 nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;membrane protein complex#GO:0098796;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;membrane#GO:0016020;endoplasmic reticulum protein-containing complex#GO:0140534;organelle membrane#GO:0031090;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=32961|UniProtKB=Q8N140 Q8N140 EID3 PTHR16140:SF1 NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4 EP300-INTERACTING INHIBITOR OF DIFFERENTIATION 3 DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;DNA damage response#GO:0006974;cellular response to stress#GO:0033554;macromolecule metabolic process#GO:0043170;nucleic acid metabolic process#GO:0090304;response to stress#GO:0006950;primary metabolic process#GO:0044238;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;nucleobase-containing compound metabolic process#GO:0006139 transferase complex#GO:1990234;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;condensed chromosome#GO:0000793;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;nucleus#GO:0005634;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=24828|UniProtKB=Q96AM1 Q96AM1 MRGPRF PTHR11334:SF3 MAS-RELATED G-PROTEIN COUPLED RECEPTOR MAS-RELATED G PROTEIN-COUPLED RECEPTOR MEMBER F transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=3381|UniProtKB=P16452 P16452 EPB42 PTHR11590:SF44 PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE PROTEIN 4.2 acyltransferase activity#GO:0016746;catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 transferase#PC00220 HUMAN|HGNC=33859|UniProtKB=Q6ZSG2 Q6ZSG2 INSYN2A PTHR28682:SF1 INHIBITORY SYNAPTIC FACTOR 2A-RELATED INHIBITORY SYNAPTIC FACTOR 2A regulation of membrane potential#GO:0042391;system process#GO:0003008;cell surface receptor signaling pathway#GO:0007166;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;synaptic signaling#GO:0099536;signal transduction#GO:0007165;cellular process#GO:0009987;cell communication#GO:0007154;regulation of biological quality#GO:0065008;trans-synaptic signaling#GO:0099537;nervous system process#GO:0050877;anterograde trans-synaptic signaling#GO:0098916;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;chemical synaptic transmission, postsynaptic#GO:0099565;chemical synaptic transmission#GO:0007268;regulation of postsynaptic membrane potential#GO:0060078;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716 neuron to neuron synapse#GO:0098984;cellular anatomical structure#GO:0110165;synapse#GO:0045202;postsynaptic specialization#GO:0099572;asymmetric synapse#GO:0032279;organelle#GO:0043226;postsynapse#GO:0098794;cell junction#GO:0030054;postsynaptic density#GO:0014069 HUMAN|HGNC=18281|UniProtKB=Q9BY49 Q9BY49 PECR PTHR24317:SF7 PEROXISOMAL TRANS-2-ENOYL-COA REDUCTASE PEROXISOMAL TRANS-2-ENOYL-COA REDUCTASE catalytic activity#GO:0003824;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627;oxidoreductase activity#GO:0016491 cellular process#GO:0009987;primary metabolic process#GO:0044238;small molecule metabolic process#GO:0044281;lipid metabolic process#GO:0006629;terpenoid metabolic process#GO:0006721;alcohol metabolic process#GO:0006066;metabolic process#GO:0008152;diterpenoid metabolic process#GO:0016101;isoprenoid metabolic process#GO:0006720 cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;peroxisome#GO:0005777;microbody#GO:0042579;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 reductase#PC00198;oxidoreductase#PC00176 HUMAN|HGNC=30031|UniProtKB=Q9BTU6 Q9BTU6 PI4K2A PTHR12865:SF7 PHOSPHATIDYLINOSITOL 4-KINASE TYPE-II PHOSPHATIDYLINOSITOL 4-KINASE TYPE 2-ALPHA phosphotransferase activity, alcohol group as acceptor#GO:0016773;lipid kinase activity#GO:0001727;kinase activity#GO:0016301;phosphatidylinositol kinase activity#GO:0052742;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824 Golgi organization#GO:0007030;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;phosphorus metabolic process#GO:0006793;phospholipid metabolic process#GO:0006644;glycerolipid metabolic process#GO:0046486;phospholipid biosynthetic process#GO:0008654;phosphatidylinositol phosphate biosynthetic process#GO:0046854;organophosphate biosynthetic process#GO:0090407;glycerolipid biosynthetic process#GO:0045017;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;organelle organization#GO:0006996;endomembrane system organization#GO:0010256;biosynthetic process#GO:0009058;glycerophospholipid metabolic process#GO:0006650;lipid biosynthetic process#GO:0008610;glycerophospholipid biosynthetic process#GO:0046474;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;vesicle organization#GO:0016050;endosome organization#GO:0007032;cellular component organization or biogenesis#GO:0071840 membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;endosome#GO:0005768;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982;Golgi apparatus#GO:0005794;endomembrane system#GO:0012505;plasma membrane#GO:0005886;trans-Golgi network#GO:0005802;cytoplasm#GO:0005737;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;cell periphery#GO:0071944 metabolite interconversion enzyme#PC00262;kinase#PC00137;transferase#PC00220 HUMAN|HGNC=56771|UniProtKB=A0A1B0GTJ6 A0A1B0GTJ6 SAXO3 PTHR37404:SF1 HCG1796489 STABILIZER OF AXONEMAL MICROTUBULES 3 HUMAN|HGNC=30939|UniProtKB=Q86UP3 Q86UP3 ZFHX4 PTHR45891:SF2 ZINC FINGER HOMEOBOX PROTEIN ZINC FINGER HOMEOBOX PROTEIN 4 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977 regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=23066|UniProtKB=Q86SZ2 Q86SZ2 TRAPPC6B PTHR12817:SF3 TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 6B TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 6B endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234;transport#GO:0006810;Golgi vesicle transport#GO:0048193;intracellular transport#GO:0046907;vesicle-mediated transport#GO:0016192;establishment of localization in cell#GO:0051649;cellular process#GO:0009987 protein-containing complex#GO:0032991;endomembrane system#GO:0012505;trans-Golgi network#GO:0005802;TRAPP complex#GO:0030008;cytoplasm#GO:0005737;Golgi apparatus subcompartment#GO:0098791;intracellular protein-containing complex#GO:0140535;vesicle tethering complex#GO:0099023;cis-Golgi network#GO:0005801;Golgi apparatus#GO:0005794;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 HUMAN|HGNC=16871|UniProtKB=Q5BIV9 Q5BIV9 SPRN PTHR28552:SF1 SHADOW OF PRION PROTEIN SHADOW OF PRION PROTEIN nucleic acid binding#GO:0003676;binding#GO:0005488 establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;import into nucleus#GO:0051170;macromolecule localization#GO:0033036;protein localization to nucleus#GO:0034504;intracellular protein transport#GO:0006886;transport#GO:0006810;intracellular transport#GO:0046907;intracellular protein localization#GO:0008104;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;protein localization to organelle#GO:0033365;nucleocytoplasmic transport#GO:0006913;nuclear transport#GO:0051169;protein import into nucleus#GO:0006606;protein transport#GO:0015031;localization#GO:0051179;cellular localization#GO:0051641 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=6067|UniProtKB=P09529 P09529 INHBB PTHR11848:SF29 TGF-BETA FAMILY INHIBIN BETA B CHAIN molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;cytokine activity#GO:0005125 signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 growth factor#PC00112 Gonadotropin-releasing hormone receptor pathway#P06664>Inhba/b#P06700;TGF-beta signaling pathway#P00052>TGFbeta#P01286 HUMAN|HGNC=11631|UniProtKB=Q9UGU0 Q9UGU0 TCF20 PTHR14955:SF7 RETINOIC ACID INDUCED 1/TRANSCRIPTION FACTOR 20 TRANSCRIPTION FACTOR 20 transcription coactivator activity#GO:0003713;transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712 regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of transcription by RNA polymerase II#GO:0045944;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 zinc finger transcription factor#PC00244 HUMAN|HGNC=32484|UniProtKB=A6NNM8 A6NNM8 TTLL13 PTHR12241:SF91 TUBULIN POLYGLUTAMYLASE TUBULIN POLYGLUTAMYLASE TTLL13 binding#GO:0005488;protein binding#GO:0005515;ligase activity, forming carbon-nitrogen bonds#GO:0016879;catalytic activity#GO:0003824;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;ligase activity#GO:0016874;catalytic activity, acting on a protein#GO:0140096 cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;cytoskeleton organization#GO:0007010;microtubule bundle formation#GO:0001578;microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;cilium#GO:0005929;intracellular organelle#GO:0043229;ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;plasma membrane bounded cell projection#GO:0120025;intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;microtubule cytoskeleton#GO:0015630 microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=8746|UniProtKB=Q6UW60 Q6UW60 PCSK4 PTHR42884:SF16 PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED PROPROTEIN CONVERTASE SUBTILISIN_KEXIN TYPE 4 serine-type peptidase activity#GO:0008236;serine hydrolase activity#GO:0017171;hydrolase activity#GO:0016787;catalytic activity#GO:0003824;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096 macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;gene expression#GO:0010467;protein maturation#GO:0051604;hormone metabolic process#GO:0042445;biosynthetic process#GO:0009058;biological regulation#GO:0065007;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;peptide hormone processing#GO:0016486;protein processing#GO:0016485;protein metabolic process#GO:0019538;signaling receptor ligand precursor processing#GO:0140448;regulation of biological quality#GO:0065008;proteolysis#GO:0006508;primary metabolic process#GO:0044238;regulation of hormone levels#GO:0010817 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;membrane#GO:0016020;Golgi apparatus subcompartment#GO:0098791;endomembrane system#GO:0012505;cytoplasm#GO:0005737;trans-Golgi network#GO:0005802;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588 serine protease#PC00203 Alzheimer disease-presenilin pathway#P00004>Furin#P00157;Alzheimer disease-amyloid secretase pathway#P00003>Furin#P00105 HUMAN|HGNC=9348|UniProtKB=Q9UKN5 Q9UKN5 PRDM4 PTHR16515:SF2 PR DOMAIN ZINC FINGER PROTEIN PR DOMAIN ZINC FINGER PROTEIN 4 transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218;zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=15520|UniProtKB=P43657 P43657 LPAR6 PTHR24232:SF3 G-PROTEIN COUPLED RECEPTOR LYSOPHOSPHATIDIC ACID RECEPTOR 6 molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;bioactive lipid receptor activity#GO:0045125;transmembrane signaling receptor activity#GO:0004888 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein coupled receptor#PC00021;transmembrane signal receptor#PC00197 HUMAN|HGNC=4054|UniProtKB=P09912 P09912 IFI6 PTHR16932:SF25 INTERFERON ALPHA-INDUCIBLE PROTEIN 27 INTERFERON ALPHA-INDUCIBLE PROTEIN 6 programmed cell death#GO:0012501;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;cell death#GO:0008219;apoptotic process#GO:0006915;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007;apoptotic signaling pathway#GO:0097190;intrinsic apoptotic signaling pathway#GO:0097193;cell communication#GO:0007154;intracellular signal transduction#GO:0035556 membrane#GO:0016020;organelle envelope#GO:0031967;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=20185|UniProtKB=Q9NX78 Q9NX78 TMEM260 PTHR16214:SF3 TRANSMEMBRANE PROTEIN 260 PROTEIN O-MANNOSYL-TRANSFERASE TMEM260 HUMAN|HGNC=25252|UniProtKB=Q8IYS0 Q8IYS0 GRAMD1C PTHR23319:SF1 GRAM DOMAIN CONTAINING 1B, ISOFORM E PROTEIN ASTER-C transporter activity#GO:0005215;sterol transfer activity#GO:0120015;cholesterol transfer activity#GO:0120020;alcohol binding#GO:0043178;steroid binding#GO:0005496;binding#GO:0005488;small molecule binding#GO:0036094;molecular carrier activity#GO:0140104;lipid carrier activity#GO:0005319;sterol binding#GO:0032934;lipid transfer activity#GO:0120013;cholesterol binding#GO:0015485;lipid binding#GO:0008289 intracellular transport#GO:0046907;lipid localization#GO:0010876;transport#GO:0006810;establishment of localization#GO:0051234;sterol transport#GO:0015918;cellular localization#GO:0051641;localization#GO:0051179;organic hydroxy compound transport#GO:0015850;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;lipid transport#GO:0006869;intracellular sterol transport#GO:0032366 endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cytoplasm#GO:0005737;endomembrane system#GO:0012505;endoplasmic reticulum subcompartment#GO:0098827;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;intracellular anatomical structure#GO:0005622;organelle membrane contact site#GO:0044232;intracellular membrane-bounded organelle#GO:0043231;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=27362|UniProtKB=P0C881 P0C881 RSPH10B PTHR46613:SF1 RADIAL SPOKE HEAD 10 HOMOLOG B-RELATED RADIAL SPOKE HEAD 10 HOMOLOG B-RELATED HUMAN|Ensembl=ENSG00000277196.4|UniProtKB=A0AAG2SXN7 A0AAG2SXN7 PTHR13914:SF0 PROLINE OXIDASE PROLINE DEHYDROGENASE-RELATED catalytic activity#GO:0003824;nucleotide binding#GO:0000166;oxidoreductase activity#GO:0016491;heterocyclic compound binding#GO:1901363;binding#GO:0005488;flavin adenine dinucleotide binding#GO:0050660;anion binding#GO:0043168;small molecule binding#GO:0036094;nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167 catabolic process#GO:0009056;small molecule metabolic process#GO:0044281;proteinogenic amino acid metabolic process#GO:0170039;small molecule catabolic process#GO:0044282;amino acid metabolic process#GO:0006520;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152 mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 oxidase#PC00175 Huntington disease#P00029>Proline oxidase#G01529 HUMAN|HGNC=17205|UniProtKB=Q9HCN3 Q9HCN3 PGAP6 PTHR14319:SF7 FIVE-SPAN TRANSMEMBRANE PROTEIN M83 POST-GPI ATTACHMENT TO PROTEINS FACTOR 6 cell adhesion molecule#PC00069 HUMAN|HGNC=27750|UniProtKB=A6NDU8 A6NDU8 RIMOC1 PTHR28494:SF1 UPF0600 PROTEIN C5ORF51 RAB7A-INTERACTING MON1-CCZ1 COMPLEX SUBUNIT 1 HUMAN|HGNC=49566|UniProtKB=P0DO97 P0DO97 CCDC192 PTHR38580:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 192 COILED-COIL DOMAIN-CONTAINING PROTEIN 192 HUMAN|HGNC=23734|UniProtKB=Q7RTS3 Q7RTS3 PTF1A PTHR23349:SF59 BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST PANCREAS TRANSCRIPTION FACTOR 1 SUBUNIT ALPHA DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=13735|UniProtKB=P49795 P49795 RGS19 PTHR10845:SF145 REGULATOR OF G PROTEIN SIGNALING REGULATOR OF G PROTEIN SIGNALING 19 molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;GTPase activator activity#GO:0005096;enzyme regulator activity#GO:0030234;enzyme activator activity#GO:0008047 biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of signal transduction#GO:0009968;regulation of cell communication#GO:0010646;negative regulation of response to stimulus#GO:0048585;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of G protein-coupled receptor signaling pathway#GO:0045744;negative regulation of cell communication#GO:0010648;regulation of signaling#GO:0023051;regulation of G protein-coupled receptor signaling pathway#GO:0008277;regulation of response to stimulus#GO:0048583;negative regulation of signaling#GO:0023057;negative regulation of cellular process#GO:0048523 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cytoplasmic side of membrane#GO:0098562;cell periphery#GO:0071944;membrane#GO:0016020;cytoplasmic side of plasma membrane#GO:0009898 GTPase-activating protein#PC00257 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>RGS#P00704;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>RGS#P00731 HUMAN|HGNC=7036|UniProtKB=Q08431 Q08431 MFGE8 PTHR24543:SF317 MULTICOPPER OXIDASE-RELATED LACTADHERIN phosphatidylserine binding#GO:0001786;lipid binding#GO:0008289;ion binding#GO:0043167;small molecule binding#GO:0036094;binding#GO:0005488;phospholipid binding#GO:0005543;anion binding#GO:0043168 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 oxidoreductase#PC00176 HUMAN|HGNC=15130|UniProtKB=Q9H209 Q9H209 OR10A4 PTHR26453:SF9 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 10A4 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 system process#GO:0003008;sensory perception#GO:0007600;nervous system process#GO:0050877;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;response to chemical#GO:0042221;response to stimulus#GO:0050896;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;detection of chemical stimulus#GO:0009593;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=6446|UniProtKB=P05787 P05787 KRT8 PTHR45616:SF26 GATA-TYPE DOMAIN-CONTAINING PROTEIN KERATIN, TYPE II CYTOSKELETAL 8 organelle assembly#GO:0070925;animal gross anatomical part developmental process#GO:0160108;cellular component assembly involved in morphogenesis#GO:0010927;sarcomere organization#GO:0045214;actin filament-based process#GO:0030029;striated muscle cell development#GO:0055002;anatomical structure development#GO:0048856;supramolecular fiber organization#GO:0097435;muscle cell development#GO:0055001;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;myofibril assembly#GO:0030239;anatomical structure morphogenesis#GO:0009653;muscle cell differentiation#GO:0042692;cell differentiation#GO:0030154;actin cytoskeleton organization#GO:0030036;muscle structure development#GO:0061061;actomyosin structure organization#GO:0031032;cell development#GO:0048468;cellular anatomical entity morphogenesis#GO:0032989;developmental process#GO:0032502;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;striated muscle cell differentiation#GO:0051146;anatomical structure formation involved in morphogenesis#GO:0048646;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;intermediate filament#GO:0005882;supramolecular fiber#GO:0099512;intracellular anatomical structure#GO:0005622;supramolecular complex#GO:0099080;organelle#GO:0043226;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232 HUMAN|HGNC=12326|UniProtKB=Q12816 Q12816 TRO PTHR11736:SF83 MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN TROPHININ negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;negative regulation of DNA-templated transcription#GO:0045892;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of macromolecule metabolic process#GO:0010605;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 scaffold/adaptor protein#PC00226 HUMAN|HGNC=14952|UniProtKB=Q8TAE6 Q8TAE6 PPP1R14C PTHR16188:SF6 PROTEIN PHOSPHATASE 1 INHIBITOR POTENTIATED BY PROTEIN KINASE C PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 14C enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678;protein phosphatase regulator activity#GO:0019888;protein serine/threonine phosphatase inhibitor activity#GO:0004865;phosphatase regulator activity#GO:0019208;phosphatase inhibitor activity#GO:0019212;molecular function regulator activity#GO:0098772;protein phosphatase inhibitor activity#GO:0004864;enzyme inhibitor activity#GO:0004857 phosphatase modulator#PC00184 HUMAN|HGNC=1101|UniProtKB=P51587 P51587 BRCA2 PTHR11289:SF0 BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2 BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN nucleic acid binding#GO:0003676;binding#GO:0005488;single-stranded DNA binding#GO:0003697;DNA binding#GO:0003677 regulation of RNA biosynthetic process#GO:2001141;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of metabolic process#GO:0019222;response to stress#GO:0006950;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;double-strand break repair#GO:0006302;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;DNA recombination#GO:0006310;DNA metabolic process#GO:0006259;DNA repair#GO:0006281;metabolic process#GO:0008152;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;double-strand break repair via homologous recombination#GO:0000724;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;cellular response to stress#GO:0033554;recombinational repair#GO:0000725 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 damaged DNA-binding protein#PC00086;DNA metabolism protein#PC00009 HUMAN|HGNC=11044|UniProtKB=P48066 P48066 SLC6A11 PTHR11616:SF124 SODIUM/CHLORIDE DEPENDENT TRANSPORTER SODIUM- AND CHLORIDE-DEPENDENT GABA TRANSPORTER 3 monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;amino acid transmembrane transporter activity#GO:0015171;transporter activity#GO:0005215;secondary active transmembrane transporter activity#GO:0015291;monoatomic anion transmembrane transporter activity#GO:0008509;monoatomic cation transmembrane transporter activity#GO:0008324;symporter activity#GO:0015293;solute:monoatomic cation symporter activity#GO:0015294;sodium ion transmembrane transporter activity#GO:0015081;active transmembrane transporter activity#GO:0022804;chloride transmembrane transporter activity#GO:0015108;transmembrane transporter activity#GO:0022857;solute:sodium symporter activity#GO:0015370;amino acid:sodium symporter activity#GO:0005283;carboxylic acid transmembrane transporter activity#GO:0046943 cellular process#GO:0009987;sodium ion transport#GO:0006814;sodium ion transmembrane transport#GO:0035725;monoatomic ion transmembrane transport#GO:0034220;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;amino acid transport#GO:0006865;transport#GO:0006810;monoatomic ion transport#GO:0006811;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane#GO:0005886 primary active transporter#PC00068 HUMAN|HGNC=1857|UniProtKB=P49454 P49454 CENPF PTHR18874:SF10 CMF/LEK/CENP CELL DIVISION-RELATED CENTROMERE PROTEIN F HUMAN|HGNC=13940|UniProtKB=Q9Y333 Q9Y333 LSM2 PTHR13829:SF2 SNRNP CORE PROTEIN FAMILY MEMBER U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM2 binding#GO:0005488;nucleic acid binding#GO:0003676;RNA binding#GO:0003723;snRNA binding#GO:0017069 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;mRNA processing#GO:0006397;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;gene expression#GO:0010467;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;macromolecule metabolic process#GO:0043170;mRNA splicing, via spliceosome#GO:0000398;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377 Sm-like protein family complex#GO:0120114;nuclear protein-containing complex#GO:0140513;U6 snRNP#GO:0005688;protein-containing complex#GO:0032991;U4/U6 x U5 tri-snRNP complex#GO:0046540;nucleus#GO:0005634;small nuclear ribonucleoprotein complex#GO:0030532;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;spliceosomal snRNP complex#GO:0097525;spliceosomal tri-snRNP complex#GO:0097526;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;precatalytic spliceosome#GO:0071011;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;spliceosomal complex#GO:0005681 RNA splicing factor#PC00148;RNA processing factor#PC00147 HUMAN|HGNC=11517|UniProtKB=P20366 P20366 TAC1 PTHR11250:SF3 TACHYKININ PROTACHYKININ-1 G protein-coupled receptor binding#GO:0001664;binding#GO:0005488;signaling receptor binding#GO:0005102;neuropeptide receptor binding#GO:0071855;protein binding#GO:0005515 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stress#GO:0006950;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;inflammatory response#GO:0006954;G protein-coupled receptor signaling pathway#GO:0007186;positive regulation of cytosolic calcium ion concentration#GO:0007204;defense response#GO:0006952;regulation of biological quality#GO:0065008;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 CCKR signaling map#P06959>TAC1#G07000;CCKR signaling map#P06959>TAC1#G07294 HUMAN|HGNC=16324|UniProtKB=O14990 O14990 PPP1R2C PTHR12398:SF29 PROTEIN PHOSPHATASE INHIBITOR PROTEIN PHOSPHATASE INHIBITOR 2 FAMILY MEMBER C molecular function inhibitor activity#GO:0140678;protein phosphatase regulator activity#GO:0019888;enzyme regulator activity#GO:0030234;enzyme inhibitor activity#GO:0004857;protein phosphatase inhibitor activity#GO:0004864;phosphatase inhibitor activity#GO:0019212;molecular function regulator activity#GO:0098772;phosphatase regulator activity#GO:0019208 cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165 phosphatase inhibitor#PC00183 HUMAN|HGNC=6867|UniProtKB=Q9Y4K4 Q9Y4K4 MAP4K5 PTHR48012:SF19 STERILE20-LIKE KINASE, ISOFORM B-RELATED MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 5 protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;transferase activity#GO:0016740;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096 signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signal transduction#GO:0007165;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 Apoptosis signaling pathway#P00006>GCK#P00268;Apoptosis signaling pathway#P00006>GCKR#P00311;Gonadotropin-releasing hormone receptor pathway#P06664>MAP4Ks#P06861 HUMAN|HGNC=9363|UniProtKB=Q9Y2Y8 Q9Y2Y8 PRG3 PTHR10068:SF8 BONE MARROW PROTEOGLYCAN PROTEOGLYCAN 3 extracellular matrix structural protein#PC00103 HUMAN|HGNC=11533|UniProtKB=Q53T94 Q53T94 TAF1B PTHR31576:SF6 TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;core promoter sequence-specific DNA binding#GO:0001046;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;nucleolar large rRNA transcription by RNA polymerase I#GO:0042790;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;rRNA transcription#GO:0009303;transcription by RNA polymerase I#GO:0006360;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304 transcription regulator complex#GO:0005667;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226 General transcription by RNA polymerase I#P00022>TAF-IB#P00650 HUMAN|HGNC=3035|UniProtKB=Q08554 Q08554 DSC1 PTHR24025:SF8 DESMOGLEIN FAMILY MEMBER DESMOCOLLIN-1 cation binding#GO:0043169;metal ion binding#GO:0046872;calcium ion binding#GO:0005509;ion binding#GO:0043167;binding#GO:0005488;small molecule binding#GO:0036094 cell-cell adhesion#GO:0098609;cell adhesion#GO:0007155;cellular process#GO:0009987 cell-cell junction#GO:0005911;cellular anatomical structure#GO:0110165;cell junction#GO:0030054;anchoring junction#GO:0070161 cadherin#PC00057 HUMAN|HGNC=18313|UniProtKB=Q96L33 Q96L33 RHOV PTHR24072:SF144 RHO FAMILY GTPASE RHO-RELATED GTP-BINDING PROTEIN RHOV hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;protein kinase binding#GO:0019901;guanyl nucleotide binding#GO:0019001;enzyme binding#GO:0019899;nucleoside phosphate binding#GO:1901265;kinase binding#GO:0019900;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;protein binding#GO:0005515;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;GTPase activity#GO:0003924;ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;hydrolase activity#GO:0016787 actin filament organization#GO:0007015;import into cell#GO:0098657;establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;transport#GO:0006810;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;cellular process#GO:0009987;signal transduction#GO:0007165;organelle organization#GO:0006996;supramolecular fiber organization#GO:0097435;cell communication#GO:0007154;localization#GO:0051179;actin filament-based process#GO:0030029;establishment or maintenance of cell polarity#GO:0007163;signaling#GO:0023052;endocytosis#GO:0006897;regulation of cellular process#GO:0050794;actin cytoskeleton organization#GO:0030036;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;establishment of cell polarity#GO:0030010;regulation of biological process#GO:0050789;cellular component organization#GO:0016043 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 G-protein#PC00020;small GTPase#PC00208 HUMAN|HGNC=29843|UniProtKB=Q6X4W1 Q6X4W1 NSMF PTHR32061:SF4 NMDA RECEPTOR SYNAPTONUCLEAR SIGNALING AND NEURONAL MIGRATION FACTOR NMDA RECEPTOR SYNAPTONUCLEAR SIGNALING AND NEURONAL MIGRATION FACTOR regulation of cell motility#GO:2000145;positive regulation of locomotion#GO:0040017;regulation of neuron migration#GO:2001222;regulation of cell migration#GO:0030334;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;positive regulation of cell motility#GO:2000147;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of biological process#GO:0050789;positive regulation of cell migration#GO:0030335 nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=2065|UniProtKB=Q96NY7 Q96NY7 CLIC6 PTHR45476:SF1 CHLORIDE INTRACELLULAR CHANNEL PROTEIN 6-RELATED CHLORIDE INTRACELLULAR CHANNEL PROTEIN 6 monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic anion transmembrane transporter activity#GO:0008509;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;chloride channel activity#GO:0005254;chloride transmembrane transporter activity#GO:0015108;passive transmembrane transporter activity#GO:0022803;channel activity#GO:0015267;monoatomic anion channel activity#GO:0005253 establishment of localization#GO:0051234;localization#GO:0051179;monoatomic ion transport#GO:0006811;monoatomic anion transport#GO:0006820;transport#GO:0006810 membrane#GO:0016020;cellular anatomical structure#GO:0110165 ion channel#PC00133 Nicotine pharmacodynamics pathway#P06587>CLIC6#P06611;Dopamine receptor mediated signaling pathway#P05912>CLIC6#P05968 HUMAN|HGNC=25278|UniProtKB=Q8N5Q1 Q8N5Q1 GARIN5B PTHR22574:SF12 FAMILY NOT NAMED GOLGI-ASSOCIATED RAB2 INTERACTOR PROTEIN 5B HUMAN|HGNC=27740|UniProtKB=P0CF97 P0CF97 FAM200B PTHR45935:SF6 PROTEIN ZBED8-RELATED PROTEIN FAM200B HUMAN|HGNC=24668|UniProtKB=Q9BXR6 Q9BXR6 CFHR5 PTHR45785:SF9 COMPLEMENT FACTOR H-RELATED COMPLEMENT FACTOR H-RELATED PROTEIN 5 complement binding#GO:0001848;binding#GO:0005488;protein binding#GO:0005515 positive regulation of immune system process#GO:0002684;positive regulation of biological process#GO:0048518;activation of immune response#GO:0002253;complement activation#GO:0006956;immune response#GO:0006955;positive regulation of response to stimulus#GO:0048584;biological regulation#GO:0065007;humoral immune response#GO:0006959;positive regulation of immune response#GO:0050778;immune effector process#GO:0002252;regulation of response to stimulus#GO:0048583;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of immune system process#GO:0002682;immune system process#GO:0002376;regulation of immune response#GO:0050776 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 complement component#PC00078 HUMAN|HGNC=11701|UniProtKB=P13385 P13385 CRIPTO PTHR14949:SF26 EGF-LIKE-DOMAIN, MULTIPLE 7, 8 PROTEIN CRIPTO binding#GO:0005488;signaling receptor binding#GO:0005102;receptor serine/threonine kinase binding#GO:0033612;protein binding#GO:0005515 signaling#GO:0023052;response to stimulus#GO:0050896;circulatory system development#GO:0072359;cell differentiation#GO:0030154;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;blood vessel morphogenesis#GO:0048514;activin receptor signaling pathway#GO:0032924;animal gross anatomical part developmental process#GO:0160108;determination of bilateral symmetry#GO:0009855;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;vasculogenesis#GO:0001570;heart development#GO:0007507;cellular process#GO:0009987;signal transduction#GO:0007165;vasculature development#GO:0001944;animal organ development#GO:0048513;multicellular organism development#GO:0007275;cell surface receptor signaling pathway#GO:0007166;left/right pattern formation#GO:0060972;regulation of cellular process#GO:0050794;blood vessel development#GO:0001568;cellular response to stimulus#GO:0051716;tube morphogenesis#GO:0035239;determination of left/right symmetry#GO:0007368;system development#GO:0048731;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;cell communication#GO:0007154;pattern specification process#GO:0007389;tube development#GO:0035295;biological regulation#GO:0065007;regionalization#GO:0003002;multicellular organismal process#GO:0032501;cellular developmental process#GO:0048869;developmental process#GO:0032502;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;specification of symmetry#GO:0009799 cellular anatomical structure#GO:0110165;cell surface#GO:0009986;extracellular region#GO:0005576 intercellular signal molecule#PC00207 HUMAN|HGNC=18158|UniProtKB=Q9H322 Q9H322 VCX2 PTHR15251:SF3 TESTIS-SPECIFIC BASIC PROTEIN Y 1-RELATED TESTIS-SPECIFIC BASIC PROTEIN Y 1-RELATED multicellular organism development#GO:0007275;animal organ development#GO:0048513;anatomical structure development#GO:0048856;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;developmental process#GO:0032502;central nervous system development#GO:0007417;brain development#GO:0007420;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;head development#GO:0060322 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=27009|UniProtKB=Q8TCI5 Q8TCI5 CIMAP3 PTHR31508:SF2 PROTEIN PITCHFORK CILIARY MICROTUBULE-ASSOCIATED PROTEIN 3 enzyme activator activity#GO:0008047;protein kinase activator activity#GO:0030295;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;protein kinase regulator activity#GO:0019887;kinase activator activity#GO:0019209;enzyme regulator activity#GO:0030234;molecular function activator activity#GO:0140677 cilium organization#GO:0044782;cellular component organization or biogenesis#GO:0071840;regulation of cell projection organization#GO:0031344;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;cell projection organization#GO:0030030;cellular process#GO:0009987;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;organelle organization#GO:0006996 membraneless organelle#GO:0043228;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;microtubule organizing center#GO:0005815;cytoskeleton#GO:0005856;ciliary basal body#GO:0036064;cilium#GO:0005929;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;microtubule cytoskeleton#GO:0015630 HUMAN|HGNC=11192|UniProtKB=Q9UN79 Q9UN79 SOX13 PTHR45789:SF4 FI18025P1 TRANSCRIPTION FACTOR SOX-13 RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 cell fate commitment#GO:0045165;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of gene expression#GO:0010468;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;developmental process#GO:0032502;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=13622|UniProtKB=Q9GZN6 Q9GZN6 SLC6A16 PTHR11616:SF327 SODIUM/CHLORIDE DEPENDENT TRANSPORTER ORPHAN SODIUM- AND CHLORIDE-DEPENDENT NEUROTRANSMITTER TRANSPORTER NTT5 amino acid transport#GO:0006865;transport#GO:0006810;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;sodium ion transmembrane transport#GO:0035725;cellular process#GO:0009987;sodium ion transport#GO:0006814;metal ion transport#GO:0030001;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion transmembrane transport#GO:0034220 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 primary active transporter#PC00068 Adrenaline and noradrenaline biosynthesis#P00001>amine translocator#P00068 HUMAN|HGNC=12478|UniProtKB=Q96LR5 Q96LR5 UBE2E2 PTHR24068:SF429 UBIQUITIN-CONJUGATING ENZYME E2 UBIQUITIN-CONJUGATING ENZYME E2 E2 catalytic activity, acting on a protein#GO:0140096;ubiquitin conjugating enzyme activity#GO:0061631;aminoacyltransferase activity#GO:0016755;catalytic activity#GO:0003824;transferase activity#GO:0016740;ubiquitin-like protein conjugating enzyme activity#GO:0061650;ubiquitin-protein transferase activity#GO:0004842;acyltransferase activity#GO:0016746;ubiquitin-like protein transferase activity#GO:0019787 protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;ISG15-protein conjugation#GO:0032020;protein modification by small protein conjugation#GO:0032446;protein polyubiquitination#GO:0000209;cellular process#GO:0009987;protein K11-linked ubiquitination#GO:0070979;protein modification process#GO:0036211;primary metabolic process#GO:0044238;protein K63-linked ubiquitination#GO:0070534;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;metabolic process#GO:0008152;protein modification by small protein conjugation or removal#GO:0070647 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 ubiquitin-protein ligase#PC00234 Ubiquitin proteasome pathway#P00060>E2#P01491 HUMAN|HGNC=24262|UniProtKB=Q9Y303 Q9Y303 AMDHD2 PTHR11113:SF14 N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;deacetylase activity#GO:0019213;hydrolase activity#GO:0016787;deacylase activity#GO:0160215;catalytic activity#GO:0003824;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811 carbohydrate derivative catabolic process#GO:1901136;amino sugar metabolic process#GO:0006040;amino sugar catabolic process#GO:0046348;catabolic process#GO:0009056;cellular process#GO:0009987;carbohydrate derivative metabolic process#GO:1901135;metabolic process#GO:0008152 metabolite interconversion enzyme#PC00262;deacetylase#PC00087 N-acetylglucosamine metabolism#P02756>N-acetylglucosamine-6-phosphate deacetylase#P03036 HUMAN|HGNC=28281|UniProtKB=Q8WUH6 Q8WUH6 TMEM263 PTHR31443:SF0 FAMILY NOT NAMED TRANSMEMBRANE PROTEIN 263 HUMAN|HGNC=11559|UniProtKB=P37837 P37837 TALDO1 PTHR10683:SF44 TRANSALDOLASE TRANSALDOLASE transketolase or transaldolase activity#GO:0016744;transaldolase activity#GO:0004801;transferase activity#GO:0016740;catalytic activity#GO:0003824 phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;small molecule metabolic process#GO:0044281;glucose 6-phosphate metabolic process#GO:0051156;nucleoside phosphate metabolic process#GO:0006753;pentose-phosphate shunt, non-oxidative branch#GO:0009052;pentose-phosphate shunt#GO:0006098;glyceraldehyde-3-phosphate metabolic process#GO:0019682;pyridine-containing compound metabolic process#GO:0072524;NADPH regeneration#GO:0006740;nucleotide metabolic process#GO:0009117;organophosphate metabolic process#GO:0019637;NADP+ metabolic process#GO:0006739;carbohydrate derivative metabolic process#GO:1901135;nicotinamide nucleotide metabolic process#GO:0046496;cellular process#GO:0009987;aldehyde metabolic process#GO:0006081;nucleobase-containing compound metabolic process#GO:0006139;metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091;nucleobase-containing small molecule metabolic process#GO:0055086 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 aldolase#PC00044;metabolite interconversion enzyme#PC00262;lyase#PC00144 Pentose phosphate pathway#P02762>Transaldolase#P03081 HUMAN|HGNC=21149|UniProtKB=P79522 P79522 PRR3 PTHR47398:SF1 PROLINE-RICH PROTEIN 3 PROLINE-RICH PROTEIN 3 phosphatase inhibitor activity#GO:0019212;molecular function regulator activity#GO:0098772;phosphatase regulator activity#GO:0019208;enzyme-substrate adaptor activity#GO:0140767;enzyme inhibitor activity#GO:0004857;protein phosphatase inhibitor activity#GO:0004864;molecular adaptor activity#GO:0060090;protein phosphatase regulator activity#GO:0019888;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234;protein-macromolecule adaptor activity#GO:0030674 regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of DNA-templated transcription#GO:0045893;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of protein-containing complex disassembly#GO:0043244;regulation of primary metabolic process#GO:0080090;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of DNA-templated transcription#GO:0006355;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;positive regulation of biosynthetic process#GO:0009891;regulation of RNA metabolic process#GO:0051252;positive regulation of cellular component organization#GO:0051130;regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;regulation of macromolecule metabolic process#GO:0060255;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789 intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;chromatin#GO:0000785;chromosome#GO:0005694;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;protein serine/threonine phosphatase complex#GO:0008287 HUMAN|HGNC=8920|UniProtKB=O75151 O75151 PHF2 PTHR23123:SF14 PHD/F-BOX CONTAINING PROTEIN LYSINE-SPECIFIC DEMETHYLASE PHF2 catalytic activity#GO:0003824;histone demethylase activity#GO:0032452;catalytic activity, acting on a protein#GO:0140096;demethylase activity#GO:0032451;protein demethylase activity#GO:0140457;histone modifying activity#GO:0140993 chromatin organization#GO:0006325;chromatin remodeling#GO:0006338;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165 histone modifying enzyme#PC00261;chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=11740|UniProtKB=P02787 P02787 TF PTHR11485:SF31 TRANSFERRIN SEROTRANSFERRIN defense response to symbiont#GO:0140546;immune response#GO:0006955;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;response to other organism#GO:0051707;defense response to other organism#GO:0098542;transport#GO:0006810;humoral immune response#GO:0006959;antimicrobial humoral response#GO:0019730;defense response#GO:0006952;response to external stimulus#GO:0009605;establishment of localization#GO:0051234;antibacterial humoral response#GO:0019731;response to external biotic stimulus#GO:0043207;metal ion transport#GO:0030001;biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;transition metal ion transport#GO:0000041;iron ion transport#GO:0006826;defense response to bacterium#GO:0042742;response to bacterium#GO:0009617;immune system process#GO:0002376;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812 recycling endosome#GO:0055037;plasma membrane#GO:0005886;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cell periphery#GO:0071944;membrane#GO:0016020;membrane-bounded organelle#GO:0043227;early endosome#GO:0005769;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endosome#GO:0005768;extracellular region#GO:0005576;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708 transfer/carrier protein#PC00219 HUMAN|HGNC=17079|UniProtKB=Q9NZ52 Q9NZ52 GGA3 PTHR45905:SF3 GOLGI-LOCALIZED, GAMMA-ADAPTIN EAR CONTAINING, ARF BINDING PROTEIN ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA3 small GTPase binding#GO:0031267;protein binding#GO:0005515;binding#GO:0005488;enzyme binding#GO:0019899 macromolecule localization#GO:0033036;cellular process#GO:0009987;vesicle-mediated transport#GO:0016192;Golgi to plasma membrane transport#GO:0006893;Golgi vesicle transport#GO:0048193;transport#GO:0006810;localization within membrane#GO:0051668;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;vesicle-mediated transport to the plasma membrane#GO:0098876;post-Golgi vesicle-mediated transport#GO:0006892;intracellular protein localization#GO:0008104 Golgi apparatus subcompartment#GO:0098791;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;trans-Golgi network#GO:0005802;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984 HUMAN|HGNC=23796|UniProtKB=Q8N7X4 Q8N7X4 MAGEB6 PTHR11736:SF139 MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN MELANOMA-ASSOCIATED ANTIGEN B6 negative regulation of cellular process#GO:0048523;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of transcription by RNA polymerase II#GO:0000122;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of RNA metabolic process#GO:0051252;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 scaffold/adaptor protein#PC00226 HUMAN|HGNC=2498|UniProtKB=Q9Y5B0 Q9Y5B0 CTDP1 PTHR23081:SF36 RNA POLYMERASE II CTD PHOSPHATASE RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721;protein serine/threonine phosphatase activity#GO:0004722 protein phosphatase#PC00195;protein modifying enzyme#PC00260 Transcription regulation by bZIP transcription factor#P00055>TFIIF#P01394;General transcription regulation#P00023>TFIIF#P00665 HUMAN|HGNC=20875|UniProtKB=Q8N8Z8 Q8N8Z8 ZNF441 PTHR24379:SF22 KRAB AND ZINC FINGER DOMAIN-CONTAINING ZINC FINGER PROTEIN 441 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264;zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=25579|UniProtKB=Q9NVE4 Q9NVE4 CCDC87 PTHR16078:SF1 COILED-COIL DOMAIN-CONTAINING PROTEIN 87 COILED-COIL DOMAIN-CONTAINING PROTEIN 87 HUMAN|HGNC=9214|UniProtKB=Q03052 Q03052 POU3F1 PTHR11636:SF75 POU DOMAIN POU DOMAIN, CLASS 3, TRANSCRIPTION FACTOR 1 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 intracellular membrane-bounded organelle#GO:0043231;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;RNA polymerase II transcription regulator complex#GO:0090575;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;transcription regulator complex#GO:0005667;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=24890|UniProtKB=Q9H1C3 Q9H1C3 GLT8D2 PTHR13778:SF2 GLYCOSYLTRANSFERASE 8 DOMAIN-CONTAINING PROTEIN GLYCOSYLTRANSFERASE 8 DOMAIN-CONTAINING PROTEIN 2 glycosyltransferase activity#GO:0016757;glucosyltransferase activity#GO:0046527;catalytic activity#GO:0003824;transferase activity#GO:0016740;hexosyltransferase activity#GO:0016758 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 glycosyltransferase#PC00111;transferase#PC00220 HUMAN|HGNC=3041|UniProtKB=Q14206 Q14206 RCAN2 PTHR10300:SF5 CALCIPRESSIN CALCIPRESSIN-2 enzyme regulator activity#GO:0030234;phosphatase regulator activity#GO:0019208;molecular function regulator activity#GO:0098772;protein phosphatase regulator activity#GO:0019888 calcium-mediated signaling#GO:0019722;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 intercellular signal molecule#PC00207 HUMAN|HGNC=29563|UniProtKB=Q53HC0 Q53HC0 CCDC92 PTHR14882:SF4 COILED-COIL DOMAIN-CONTAINING 74A COILED-COIL DOMAIN-CONTAINING PROTEIN 92 pattern recognition receptor signaling pathway#GO:0002221;defense response#GO:0006952;positive regulation of response to biotic stimulus#GO:0002833;regulation of innate immune response#GO:0045088;regulation of response to stimulus#GO:0048583;positive regulation of defense response#GO:0031349;positive regulation of immune response#GO:0050778;regulation of response to stress#GO:0080134;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;positive regulation of innate immune response#GO:0045089;activation of innate immune response#GO:0002218;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;regulation of defense response#GO:0031347;inflammatory response#GO:0006954;regulation of immune response#GO:0050776;regulation of response to biotic stimulus#GO:0002831;intracellular receptor signaling pathway#GO:0030522;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;cellular response to stimulus#GO:0051716;innate immune response-activating signaling pathway#GO:0002758;protein-containing complex organization#GO:0043933;positive regulation of response to external stimulus#GO:0032103;cellular component organization or biogenesis#GO:0071840;immune response-activating signaling pathway#GO:0002757;regulation of response to external stimulus#GO:0032101;cellular component assembly#GO:0022607;cellular process#GO:0009987;activation of immune response#GO:0002253;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;response to stress#GO:0006950;positive regulation of immune system process#GO:0002684;cellular component biogenesis#GO:0044085;cytoplasmic pattern recognition receptor signaling pathway#GO:0002753;immune system process#GO:0002376;signaling#GO:0023052;response to stimulus#GO:0050896;immune response-regulating signaling pathway#GO:0002764;regulation of biological process#GO:0050789;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043 microtubule cytoskeleton#GO:0015630;cellular anatomical structure#GO:0110165;organelle#GO:0043226;centriole#GO:0005814;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;centrosome#GO:0005813;microtubule organizing center#GO:0005815;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=13741|UniProtKB=Q9NY99 Q9NY99 SNTG2 PTHR10554:SF3 SYNTROPHIN GAMMA-2-SYNTROPHIN plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;membrane protein complex#GO:0098796;membrane#GO:0016020;dystrophin-associated glycoprotein complex#GO:0016010 scaffold/adaptor protein#PC00226 HUMAN|HGNC=1043|UniProtKB=P02818 P02818 BGLAP PTHR14235:SF0 OSTEOCALCIN OSTEOCALCIN structural molecule activity#GO:0005198;small molecule binding#GO:0036094;binding#GO:0005488 ossification#GO:0001503;multicellular organismal process#GO:0032501;cell differentiation#GO:0030154;cellular process#GO:0009987;bone development#GO:0060348;cellular developmental process#GO:0048869;animal organ development#GO:0048513;anatomical structure development#GO:0048856;skeletal system development#GO:0001501;multicellular organism development#GO:0007275;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;osteoblast differentiation#GO:0001649;developmental process#GO:0032502 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 HUMAN|HGNC=4817|UniProtKB=P49590 P49590 HARS2 PTHR11476:SF6 HISTIDYL-TRNA SYNTHETASE HISTIDINE--TRNA LIGASE, MITOCHONDRIAL catalytic activity, acting on a tRNA#GO:0140101;RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488;catalytic activity, acting on RNA#GO:0140098;ligase activity#GO:0016874;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity#GO:0003824 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;mitochondrial translation#GO:0032543;protein biosynthetic process#GO:0160307;translation#GO:0006412;protein metabolic process#GO:0019538;RNA metabolic process#GO:0016070;mitochondrial gene expression#GO:0140053;tRNA aminoacylation#GO:0043039;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;tRNA aminoacylation for protein translation#GO:0006418;gene expression#GO:0010467;amino acid metabolic process#GO:0006520;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;tRNA metabolic process#GO:0006399;metabolic process#GO:0008152;amino acid activation#GO:0043038;macromolecule metabolic process#GO:0043170 organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cytosol#GO:0005829;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229 aminoacyl-tRNA synthetase#PC00047;translational protein#PC00263 HUMAN|HGNC=2764|UniProtKB=Q01523 Q01523 DEFA5 PTHR11876:SF6 ALPHA-DEFENSIN 1 DEFENSIN ALPHA 5 antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844;defense response to bacterium#GO:0042742;response to bacterium#GO:0009617;immune system process#GO:0002376;defense response to Gram-negative bacterium#GO:0050829;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to stimulus#GO:0050896;defense response to Gram-positive bacterium#GO:0050830;defense response#GO:0006952;response to external stimulus#GO:0009605;antibacterial humoral response#GO:0019731;innate immune response#GO:0045087;antimicrobial humoral response#GO:0019730;humoral immune response#GO:0006959;response to other organism#GO:0051707;defense response to other organism#GO:0098542;defense response to symbiont#GO:0140546;immune response#GO:0006955;response to stress#GO:0006950;response to biotic stimulus#GO:0009607 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 antimicrobial response protein#PC00051 HUMAN|HGNC=11511|UniProtKB=Q9BQG1 Q9BQG1 SYT3 PTHR10024:SF176 SYNAPTOTAGMIN SYNAPTOTAGMIN-3 protein binding#GO:0005515;molecular sensor activity#GO:0140299;lipid binding#GO:0008289;molecular function regulator activity#GO:0098772;binding#GO:0005488;phospholipid binding#GO:0005543;SNARE binding#GO:0000149 biological regulation#GO:0065007;cell-cell signaling#GO:0007267;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of transport#GO:0051050;positive regulation of cellular process#GO:0048522;synaptic signaling#GO:0099536;positive regulation of vesicle fusion#GO:0031340;regulation of transport#GO:0051049;regulation of localization#GO:0032879;establishment of localization#GO:0051234;transport#GO:0006810;signaling#GO:0023052;regulation of cellular process#GO:0050794;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular component organization#GO:0051128;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;chemical synaptic transmission#GO:0007268;regulation of exocytosis#GO:0017157;regulation of secretion by cell#GO:1903530;positive regulation of organelle organization#GO:0010638;cell communication#GO:0007154;regulation of secretion#GO:0051046;localization#GO:0051179;positive regulation of cellular component organization#GO:0051130;trans-synaptic signaling#GO:0099537 transport vesicle#GO:0030133;endomembrane system#GO:0012505;plasma membrane#GO:0005886;cytoplasm#GO:0005737;membrane#GO:0016020;secretory vesicle#GO:0099503;cell periphery#GO:0071944;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;intracellular organelle#GO:0043229;exocytic vesicle#GO:0070382;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;intracellular vesicle#GO:0097708;vesicle#GO:0031982 membrane trafficking regulatory protein#PC00151 Synaptic vesicle trafficking#P05734>Synaptotagmin#P05769 HUMAN|HGNC=20502|UniProtKB=Q6ZMH5 Q6ZMH5 SLC39A5 PTHR12191:SF17 SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER ZIP5 monoatomic cation transmembrane transporter activity#GO:0008324;transition metal ion transmembrane transporter activity#GO:0046915;symporter activity#GO:0015293;solute:monoatomic cation symporter activity#GO:0015294;monoatomic ion transmembrane transporter activity#GO:0015075;metal ion transmembrane transporter activity#GO:0046873;active transmembrane transporter activity#GO:0022804;bicarbonate transmembrane transporter activity#GO:0015106;zinc ion transmembrane transporter activity#GO:0005385;secondary active transmembrane transporter activity#GO:0015291;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 import across plasma membrane#GO:0098739;inorganic ion import across plasma membrane#GO:0099587;homeostatic process#GO:0042592;metal ion transport#GO:0030001;intracellular monoatomic ion homeostasis#GO:0006873;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;monoatomic ion transport#GO:0006811;transition metal ion transport#GO:0000041;zinc ion transmembrane transport#GO:0071577;monoatomic ion transmembrane transport#GO:0034220;zinc ion transport#GO:0006829;monoatomic cation transmembrane transport#GO:0098655;monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;import into cell#GO:0098657;establishment of localization#GO:0051234;cellular homeostasis#GO:0019725;inorganic cation import across plasma membrane#GO:0098659;intracellular chemical homeostasis#GO:0055082;transport#GO:0006810;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;chemical homeostasis#GO:0048878 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transporter#PC00227;secondary carrier transporter#PC00258 HUMAN|HGNC=3401|UniProtKB=P07099 P07099 EPHX1 PTHR21661:SF78 EPOXIDE HYDROLASE 1-RELATED EPOXIDE HYDROLASE 1 catalytic activity#GO:0003824;hydrolase activity#GO:0016787;ether hydrolase activity#GO:0016803 unsaturated fatty acid metabolic process#GO:0033559;lipid metabolic process#GO:0006629;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;fatty acid metabolic process#GO:0006631;olefinic compound metabolic process#GO:0120254;small molecule metabolic process#GO:0044281;icosanoid metabolic process#GO:0006690;cellular process#GO:0009987;arachidonate metabolic process#GO:0019369;monocarboxylic acid metabolic process#GO:0032787;long-chain fatty acid metabolic process#GO:0001676;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752 hydrolase#PC00121 HUMAN|HGNC=6765|UniProtKB=Q13477 Q13477 MADCAM1 PTHR14162:SF1 MUCOSAL ADDRESSIN CELL ADHESION MOLECULE-1 MUCOSAL ADDRESSIN CELL ADHESION MOLECULE 1 integrin binding#GO:0005178;protein-containing complex binding#GO:0044877;protein binding#GO:0005515;cell adhesion mediator activity#GO:0098631;cell adhesion molecule binding#GO:0050839;signaling receptor binding#GO:0005102;binding#GO:0005488 cell migration#GO:0016477;biological regulation#GO:0065007;cell-cell adhesion#GO:0098609;leukocyte cell-cell adhesion#GO:0007159;signal transduction#GO:0007165;cellular process#GO:0009987;leukocyte migration#GO:0050900;cell surface receptor signaling pathway#GO:0007166;response to stimulus#GO:0050896;heterotypic cell-cell adhesion#GO:0034113;regulation of cellular process#GO:0050794;cell motility#GO:0048870;signaling#GO:0023052;integrin-mediated signaling pathway#GO:0007229;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;immune system process#GO:0002376;cell adhesion#GO:0007155 cell adhesion molecule#PC00069 HUMAN|HGNC=26939|UniProtKB=Q9P013 Q9P013 CWC15 PTHR12718:SF2 CELL CYCLE CONTROL PROTEIN CWF15 SPLICEOSOME-ASSOCIATED PROTEIN CWC15 HOMOLOG nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 RNA splicing, via transesterification reactions#GO:0000375;nucleic acid biosynthetic process#GO:0141187;RNA metabolic process#GO:0016070;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;mRNA splicing, via spliceosome#GO:0000398;mRNA cis splicing, via spliceosome#GO:0045292;mRNA metabolic process#GO:0016071;RNA biosynthetic process#GO:0032774;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA splicing#GO:0008380;macromolecule metabolic process#GO:0043170;mRNA processing#GO:0006397;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;catalytic step 2 spliceosome#GO:0071013;nuclear protein-containing complex#GO:0140513;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ribonucleoprotein complex#GO:1990904;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;nucleus#GO:0005634;spliceosomal complex#GO:0005681 HUMAN|HGNC=11876|UniProtKB=O15393 O15393 TMPRSS2 PTHR24253:SF89 TRANSMEMBRANE PROTEASE SERINE TRANSMEMBRANE PROTEASE SERINE 2 catalytic activity#GO:0003824;serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;serine hydrolase activity#GO:0017171;peptidase activity#GO:0008233 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;proteolysis#GO:0006508;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604;cellular process#GO:0009987;protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 protease#PC00190;serine protease#PC00203;protein modifying enzyme#PC00260 HUMAN|HGNC=18141|UniProtKB=Q9UHG0 Q9UHG0 DCDC2 PTHR23004:SF5 DOUBLECORTIN DOMAIN CONTAINING 2 DOUBLECORTIN DOMAIN-CONTAINING PROTEIN 2 generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cilium organization#GO:0044782;regulation of organelle organization#GO:0033043;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;cilium assembly#GO:0060271;regulation of cellular component biogenesis#GO:0044087;regulation of plasma membrane bounded cell projection assembly#GO:0120032;regulation of cellular component organization#GO:0051128;cell projection organization#GO:0030030;cell differentiation#GO:0030154;regulation of cilium assembly#GO:1902017;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;nervous system development#GO:0007399;cellular component assembly#GO:0022607;organelle assembly#GO:0070925;regulation of cell projection assembly#GO:0060491;system development#GO:0048731;anatomical structure development#GO:0048856;regulation of cellular process#GO:0050794;cell motility#GO:0048870;developmental process#GO:0032502;plasma membrane bounded cell projection assembly#GO:0120031;regulation of cell projection organization#GO:0031344;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;neuron migration#GO:0001764;regulation of plasma membrane bounded cell projection organization#GO:0120035;regulation of organelle assembly#GO:1902115;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;cell migration#GO:0016477;multicellular organismal process#GO:0032501 non-motile cilium#GO:0097730;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cluster of actin-based cell projections#GO:0098862;supramolecular fiber#GO:0099512;axoneme#GO:0005930;microtubule#GO:0005874;intracellular organelle#GO:0043229;cilium#GO:0005929;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;supramolecular polymer#GO:0099081;ciliary plasm#GO:0097014;supramolecular complex#GO:0099080;neuron projection#GO:0043005;microtubule cytoskeleton#GO:0015630 HUMAN|HGNC=31910|UniProtKB=Q6DN72 Q6DN72 FCRL6 PTHR11481:SF62 IMMUNOGLOBULIN FC RECEPTOR FC RECEPTOR-LIKE PROTEIN 6 transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 immune system process#GO:0002376;cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;immune response#GO:0006955;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052 plasma membrane#GO:0005886;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=15465|UniProtKB=Q9NQX3 Q9NQX3 GPHN PTHR10192:SF33 MOLYBDOPTERIN BIOSYNTHESIS PROTEIN GEPHYRIN transferase activity#GO:0016740;catalytic activity#GO:0003824 intracellular protein localization#GO:0008104;neuromuscular junction development#GO:0007528;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;biosynthetic process#GO:0009058;membrane organization#GO:0061024;cellular process#GO:0009987;organophosphate metabolic process#GO:0019637;macromolecule localization#GO:0033036;cellular localization#GO:0051641;organophosphate biosynthetic process#GO:0090407;protein metabolic process#GO:0019538;localization#GO:0051179;receptor clustering#GO:0043113;localization within membrane#GO:0051668;synapse organization#GO:0050808;postsynapse organization#GO:0099173;cell junction organization#GO:0034330;phosphorus metabolic process#GO:0006793;cellular component organization#GO:0016043;primary metabolic process#GO:0044238;protein localization to membrane#GO:0072657 cytoplasm#GO:0005737;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;cell periphery#GO:0071944;neuron projection#GO:0043005;membrane#GO:0016020;cytosol#GO:0005829;cell junction#GO:0030054;synaptic membrane#GO:0097060;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;postsynapse#GO:0098794;intracellular anatomical structure#GO:0005622;dendritic tree#GO:0097447;dendrite#GO:0030425;postsynaptic membrane#GO:0045211 HUMAN|HGNC=19100|UniProtKB=Q5VWK5 Q5VWK5 IL23R PTHR23036:SF112 CYTOKINE RECEPTOR INTERLEUKIN-23 RECEPTOR molecular transducer activity#GO:0060089;protein binding#GO:0005515;transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488;signaling receptor activity#GO:0038023;cytokine binding#GO:0019955;immune receptor activity#GO:0140375;cytokine receptor activity#GO:0004896 response to cytokine#GO:0034097;response to chemical#GO:0042221;biological regulation#GO:0065007;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165;cell surface receptor signaling pathway#GO:0007166;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;signaling#GO:0023052;positive regulation of cell population proliferation#GO:0008284;cellular response to stimulus#GO:0051716;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;cell communication#GO:0007154;regulation of cell population proliferation#GO:0042127;response to peptide#GO:1901652;cytokine-mediated signaling pathway#GO:0019221 signaling receptor complex#GO:0043235;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane#GO:0016020;membrane protein complex#GO:0098796 transmembrane signal receptor#PC00197 HUMAN|HGNC=20973|UniProtKB=O94910 O94910 ADGRL1 PTHR12011:SF62 ADHESION G-PROTEIN COUPLED RECEPTOR ADHESION G PROTEIN-COUPLED RECEPTOR L1 transmembrane signaling receptor activity#GO:0004888;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signaling#GO:0023052;biological regulation#GO:0065007;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 synaptic membrane#GO:0097060;cell junction#GO:0030054;membrane#GO:0016020;cell periphery#GO:0071944;presynapse#GO:0098793;synapse#GO:0045202;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;presynaptic membrane#GO:0042734;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=28214|UniProtKB=Q7Z6J6 Q7Z6J6 FRMD5 PTHR23280:SF5 4.1 G PROTEIN FERM DOMAIN-CONTAINING PROTEIN 5 regulation of cell adhesion#GO:0030155;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;positive regulation of cell adhesion#GO:0045785;regulation of biological process#GO:0050789;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518 cellular anatomical structure#GO:0110165;cell junction#GO:0030054;anchoring junction#GO:0070161;adherens junction#GO:0005912;cell-cell junction#GO:0005911 actin or actin-binding cytoskeletal protein#PC00041;cytoskeletal protein#PC00085;non-motor actin binding protein#PC00165 HUMAN|HGNC=17514|UniProtKB=Q9NSC5 Q9NSC5 HOMER3 PTHR10918:SF4 HOMER HOMER PROTEIN HOMOLOG 3 G protein-coupled receptor binding#GO:0001664;signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515 regulation of transport#GO:0051049;regulation of localization#GO:0032879;cell surface receptor signaling pathway#GO:0007166;regulation of calcium ion transport#GO:0051924;biological regulation#GO:0065007;regulation of monoatomic ion transport#GO:0043269;signal transduction#GO:0007165;cellular process#GO:0009987;glutamate receptor signaling pathway#GO:0007215;cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of metal ion transport#GO:0010959;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716 neuron projection#GO:0043005;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;cytoplasm#GO:0005737;postsynaptic specialization#GO:0099572;neuron to neuron synapse#GO:0098984;cell junction#GO:0030054;postsynapse#GO:0098794;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;asymmetric synapse#GO:0032279;organelle#GO:0043226;synapse#GO:0045202;cellular anatomical structure#GO:0110165;dendritic tree#GO:0097447;postsynaptic density#GO:0014069;dendrite#GO:0030425;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=10766|UniProtKB=Q15428 Q15428 SF3A2 PTHR23205:SF0 SPLICING FACTOR 3A SUBUNIT 2 SPLICING FACTOR 3A SUBUNIT 2 ribonucleoprotein complex biogenesis#GO:0022613;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;protein-containing complex assembly#GO:0065003;mRNA splicing, via spliceosome#GO:0000398;cellular component organization#GO:0016043;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;protein-RNA complex assembly#GO:0022618;spliceosomal complex assembly#GO:0000245;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;RNA processing#GO:0006396;gene expression#GO:0010467;cellular component assembly#GO:0022607;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;cellular component biogenesis#GO:0044085;mRNA processing#GO:0006397;protein-containing complex organization#GO:0043933;protein-RNA complex organization#GO:0071826;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;RNA splicing#GO:0008380;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152 spliceosomal complex#GO:0005681;organelle#GO:0043226;cellular anatomical structure#GO:0110165;U2-type prespliceosome#GO:0071004;intracellular membrane-bounded organelle#GO:0043231;U2-type spliceosomal complex#GO:0005684;ribonucleoprotein complex#GO:1990904;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;spliceosomal snRNP complex#GO:0097525;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;small nuclear ribonucleoprotein complex#GO:0030532;nucleus#GO:0005634;protein-containing complex#GO:0032991;U2 snRNP#GO:0005686;nuclear protein-containing complex#GO:0140513;catalytic step 2 spliceosome#GO:0071013;Sm-like protein family complex#GO:0120114 RNA processing factor#PC00147;RNA metabolism protein#PC00031;RNA splicing factor#PC00148 HUMAN|HGNC=3388|UniProtKB=P54764 P54764 EPHA4 PTHR46877:SF18 EPH RECEPTOR A5 EPHRIN TYPE-A RECEPTOR 4 signaling receptor activity#GO:0038023;transmembrane receptor protein kinase activity#GO:0019199;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740;protein tyrosine kinase activity#GO:0004713;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;transmembrane receptor protein tyrosine kinase activity#GO:0004714;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 multicellular organismal process#GO:0032501;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;axon development#GO:0061564;axon guidance#GO:0007411;cellular developmental process#GO:0048869;neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;ephrin receptor signaling pathway#GO:0048013;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;system development#GO:0048731;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;nervous system development#GO:0007399;cell morphogenesis involved in neuron differentiation#GO:0048667;neuron projection development#GO:0031175;signal transduction#GO:0007165;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cell projection morphogenesis#GO:0048858;neuron differentiation#GO:0030182;cell surface receptor signaling pathway#GO:0007166;plasma membrane bounded cell projection morphogenesis#GO:0120039;response to stimulus#GO:0050896;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell morphogenesis#GO:0000902;signaling#GO:0023052;cell development#GO:0048468;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;axonogenesis#GO:0007409;neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699 cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;somatodendritic compartment#GO:0036477;cell projection#GO:0042995;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005;dendrite#GO:0030425;dendritic tree#GO:0097447 transmembrane signal receptor#PC00197 HUMAN|HGNC=25361|UniProtKB=Q8N264 Q8N264 ARHGAP24 PTHR15228:SF19 SPERMATHECAL PHYSIOLOGY VARIANT RHO GTPASE-ACTIVATING PROTEIN 24 enzyme activator activity#GO:0008047;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;molecular function activator activity#GO:0140677 anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of cellular component biogenesis#GO:0044087;regulation of plasma membrane bounded cell projection assembly#GO:0120032;response to stimulus#GO:0050896;regulation of cellular component organization#GO:0051128;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;animal gross anatomical part developmental process#GO:0160108;negative regulation of cell communication#GO:0010648;wound healing#GO:0042060;negative regulation of intracellular signal transduction#GO:1902532;cellular process#GO:0009987;response to stress#GO:0006950;negative regulation of signal transduction#GO:0009968;regulation of small GTPase mediated signal transduction#GO:0051056;morphogenesis of an epithelium#GO:0002009;negative regulation of cellular component organization#GO:0051129;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;cell motility#GO:0048870;regulation of cell projection assembly#GO:0060491;tissue morphogenesis#GO:0048729;anatomical structure development#GO:0048856;response to wounding#GO:0009611;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;epithelium development#GO:0060429;negative regulation of response to stimulus#GO:0048585;tissue development#GO:0009888;cell migration#GO:0016477;developmental process#GO:0032502;regulation of response to stimulus#GO:0048583;regulation of cell projection organization#GO:0031344;negative regulation of cellular process#GO:0048523;regulation of plasma membrane bounded cell projection organization#GO:0120035 anchoring junction#GO:0070161;focal adhesion#GO:0005925;cell-substrate junction#GO:0030055;cellular anatomical structure#GO:0110165;cell junction#GO:0030054 G-protein modulator#PC00022;protein-binding activity modulator#PC00095;GTPase-activating protein#PC00257 HUMAN|HGNC=13384|UniProtKB=Q9H195 Q9H195 MUC3B PTHR24041:SF22 MUCIN MUCIN-3A-RELATED cell adhesion molecule#PC00069 HUMAN|HGNC=12114|UniProtKB=A0A075B6X5 A0A075B6X5 TRAV18 PTHR19367:SF18 T-CELL RECEPTOR ALPHA CHAIN V REGION T CELL RECEPTOR ALPHA VARIABLE 18 response to stimulus#GO:0050896;adaptive immune response#GO:0002250;immune system process#GO:0002376;immune response#GO:0006955 protein-containing complex#GO:0032991 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=24768|UniProtKB=Q6ZV29 Q6ZV29 PNPLA7 PTHR14226:SF23 NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER PATATIN-LIKE PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN 7 phosphatidylcholine lysophospholipase A1 activity#GO:0004622;lipase activity#GO:0016298;carboxylic ester hydrolase activity#GO:0052689;hydrolase activity#GO:0016787;glycerophospholipase activity#GO:0004620;catalytic activity#GO:0003824;phospholipase activity#GO:0120569;hydrolase activity, acting on ester bonds#GO:0016788 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 hydrolase#PC00121;esterase#PC00097 HUMAN|HGNC=4605|UniProtKB=P07492 P07492 GRP PTHR16866:SF2 GASTRIN-RELEASING PEPTIDE GASTRIN-RELEASING PEPTIDE regulation of response to stress#GO:0080134;regulation of response to stimulus#GO:0048583;regulation of defense response#GO:0031347;positive regulation of defense response#GO:0031349;positive regulation of response to stimulus#GO:0048584;regulation of multicellular organismal process#GO:0051239;biological regulation#GO:0065007;positive regulation of multicellular organismal process#GO:0051240;positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789 HUMAN|HGNC=21317|UniProtKB=Q7RTS9 Q7RTS9 DYM PTHR12895:SF9 DYMECLIN DYMECLIN Golgi organization#GO:0007030;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;endomembrane system organization#GO:0010256;cellular component organization or biogenesis#GO:0071840 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165 HUMAN|HGNC=29006|UniProtKB=O15027 O15027 SEC16A PTHR13402:SF13 RGPR-RELATED PROTEIN TRANSPORT PROTEIN SEC16A intracellular anatomical structure#GO:0005622;cytoplasmic vesicle#GO:0031410;coated vesicle#GO:0030135;membrane-bounded organelle#GO:0043227;COPII-coated ER to Golgi transport vesicle#GO:0030134;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;coated vesicle membrane#GO:0030662;cellular anatomical structure#GO:0110165;organelle#GO:0043226;vesicle#GO:0031982;intracellular vesicle#GO:0097708;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;endoplasmic reticulum#GO:0005783;endoplasmic reticulum exit site#GO:0070971;ER to Golgi transport vesicle membrane#GO:0012507;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cytoplasmic vesicle membrane#GO:0030659;transport vesicle membrane#GO:0030658;transport vesicle#GO:0030133;membrane#GO:0016020;vesicle membrane#GO:0012506 HUMAN|HGNC=3490|UniProtKB=P50549 P50549 ETV1 PTHR11849:SF196 ETS ETS TRANSLOCATION VARIANT 1 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110 regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;developmental process#GO:0032502;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of macromolecule metabolic process#GO:0060255;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 winged helix/forkhead transcription factor#PC00246;DNA-binding transcription factor#PC00218 HUMAN|HGNC=16820|UniProtKB=Q14162 Q14162 SCARF1 PTHR24043:SF0 SCAVENGER RECEPTOR CLASS F SCAVENGER RECEPTOR CLASS F MEMBER 1 cargo receptor activity#GO:0038024;protein-containing complex binding#GO:0044877;binding#GO:0005488;lipoprotein particle binding#GO:0071813;protein-lipid complex binding#GO:0071814;low-density lipoprotein particle binding#GO:0030169 developmental process#GO:0032502;regulation of cell projection organization#GO:0031344;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;cell maturation#GO:0048469;regulation of plasma membrane bounded cell projection organization#GO:0120035;positive regulation of cellular process#GO:0048522;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;developmental maturation#GO:0021700;positive regulation of cell projection organization#GO:0031346;system development#GO:0048731;anatomical structure development#GO:0048856;anatomical structure maturation#GO:0071695;regulation of cellular process#GO:0050794;neuron differentiation#GO:0030182;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cellular process#GO:0009987;heterophilic cell-cell adhesion#GO:0007157;positive regulation of biological process#GO:0048518;regulation of neuron projection development#GO:0010975;cell-cell adhesion#GO:0098609;neuron projection development#GO:0031175;nervous system development#GO:0007399;positive regulation of cellular component organization#GO:0051130;generation of neurons#GO:0048699;cell adhesion#GO:0007155;animal gross anatomical part developmental process#GO:0160108;positive regulation of neuron projection development#GO:0010976;neuron development#GO:0048666;dendrite development#GO:0016358;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;cell development#GO:0048468;regulation of cellular component organization#GO:0051128;cell differentiation#GO:0030154;cell projection organization#GO:0030030 cellular anatomical structure#GO:0110165;membrane#GO:0016020 membrane traffic protein#PC00150 HUMAN|HGNC=27584|UniProtKB=Q641Q3 Q641Q3 METRNL PTHR28593:SF1 METEORIN-LIKE PROTEIN METEORIN-LIKE PROTEIN molecular function activator activity#GO:0140677;hormone activity#GO:0005179;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018 multicellular organismal-level homeostasis#GO:0048871;positive regulation of cell differentiation#GO:0045597;regulation of cell differentiation#GO:0045595;positive regulation of developmental process#GO:0051094;positive regulation of fat cell differentiation#GO:0045600;biological regulation#GO:0065007;homeostatic process#GO:0042592;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;multicellular organismal process#GO:0032501;regulation of biological process#GO:0050789;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 HUMAN|HGNC=26058|UniProtKB=Q14657 Q14657 LAGE3 PTHR31283:SF19 EKC/KEOPS COMPLEX SUBUNIT PCC1 FAMILY MEMBER EKC_KEOPS COMPLEX SUBUNIT LAGE3 transferase complex#GO:1990234;catalytic complex#GO:1902494;protein-containing complex#GO:0032991 HUMAN|HGNC=1612|UniProtKB=O00421 O00421 CCRL2 PTHR10489:SF655 CELL ADHESION MOLECULE C-C CHEMOKINE RECEPTOR-LIKE 2 protein binding#GO:0005515;molecular transducer activity#GO:0060089;binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888;immune receptor activity#GO:0140375;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;cytokine binding#GO:0019955;cytokine receptor activity#GO:0004896 calcium-mediated signaling#GO:0019722;defense response#GO:0006952;response to external stimulus#GO:0009605;response to stress#GO:0006950;cellular process#GO:0009987;immune response#GO:0006955;signal transduction#GO:0007165;cell migration#GO:0016477;taxis#GO:0042330;response to chemical#GO:0042221;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;positive regulation of cytosolic calcium ion concentration#GO:0007204;immune system process#GO:0002376;cellular response to chemical stimulus#GO:0070887;inflammatory response#GO:0006954;chemotaxis#GO:0006935;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of biological quality#GO:0065008;cell chemotaxis#GO:0060326;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cell motility#GO:0048870;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;locomotion#GO:0040011;signaling#GO:0023052 plasma membrane#GO:0005886;cytoplasm#GO:0005737;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;side of membrane#GO:0098552;external side of plasma membrane#GO:0009897 cell adhesion molecule#PC00069 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CHKR#P00854 HUMAN|HGNC=29091|UniProtKB=O75143 O75143 ATG13 PTHR13430:SF4 AUTOPHAGY-RELATED PROTEIN 13 AUTOPHAGY-RELATED PROTEIN 13 enzyme regulator activity#GO:0030234;protein kinase regulator activity#GO:0019887;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772 macroautophagy#GO:0016236;cellular component assembly#GO:0022607;autophagosome organization#GO:1905037;cellular process#GO:0009987;autophagy#GO:0006914;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;macromolecule localization#GO:0033036;autophagosome assembly#GO:0000045;intracellular protein localization#GO:0008104;mitophagy#GO:0000423;cellular component organization or biogenesis#GO:0071840;autophagy of mitochondrion#GO:0000422;metabolic process#GO:0008152;piecemeal microautophagy of the nucleus#GO:0034727;catabolic process#GO:0009056;cellular component organization#GO:0016043;process utilizing autophagic mechanism#GO:0061919;vacuole organization#GO:0007033;localization#GO:0051179;organelle assembly#GO:0070925 protein kinase complex#GO:1902911;phagophore assembly site#GO:0000407;transferase complex#GO:1990234;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;vacuole#GO:0005773;cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;serine/threonine protein kinase complex#GO:1902554;autophagosome#GO:0005776;transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=16867|UniProtKB=O75150 O75150 RNF40 PTHR23163:SF4 RING FINGER PROTEIN-RELATED E3 UBIQUITIN-PROTEIN LIGASE BRE1B ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096;transferase activity#GO:0016740;catalytic activity#GO:0003824 transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;nucleus#GO:0005634;chromatin#GO:0000785;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ubiquitin ligase complex#GO:0000151;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=9414|UniProtKB=Q13976 Q13976 PRKG1 PTHR24353:SF68 CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE SUBFAMILY NOT NAMED cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 Endothelin signaling pathway#P00019>PKG#P00567;CCKR signaling map#P06959>cGK 1#P07149 HUMAN|HGNC=16610|UniProtKB=O14633 O14633 LCE2B PTHR48615:SF7 LATE CORNIFIED ENVELOPE PROTEIN 1C LATE CORNIFIED ENVELOPE PROTEIN 2A-RELATED HUMAN|HGNC=37164|UniProtKB=P0CJ74 P0CJ74 MTRNR2L7 PTHR33895:SF2 HUMANIN-LIKE 4 HUMANIN-LIKE 7 signaling receptor regulator activity#GO:0030545;molecular function regulator activity#GO:0098772;molecular function inhibitor activity#GO:0140678;signaling receptor inhibitor activity#GO:0030547 biological regulation#GO:0065007;negative regulation of apoptotic process#GO:0043066;regulation of cellular process#GO:0050794;negative regulation of programmed cell death#GO:0043069;regulation of biological process#GO:0050789;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;regulation of apoptotic process#GO:0042981;negative regulation of cellular process#GO:0048523 HUMAN|HGNC=51239|UniProtKB=Q3ZCU0 Q3ZCU0 GVQW3 PTHR46060:SF3 MARINER MOS1 TRANSPOSASE-LIKE PROTEIN PROTEIN GVQW3 viral or transposable element protein#PC00237 HUMAN|HGNC=9846|UniProtKB=P62826 P62826 RAN PTHR24071:SF43 RAN GTPASE GTP-BINDING NUCLEAR PROTEIN RAN hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;GTPase activity#GO:0003924;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787 mRNA transport#GO:0051028;establishment of RNA localization#GO:0051236;RNA localization#GO:0006403;RNA transport#GO:0050658;protein localization to organelle#GO:0033365;nucleobase-containing compound transport#GO:0015931;nuclear export#GO:0051168;nuclear transport#GO:0051169;nucleic acid transport#GO:0050657;localization#GO:0051179;nucleocytoplasmic transport#GO:0006913;ribosomal small subunit export from nucleus#GO:0000056;ribosome localization#GO:0033750;organelle localization#GO:0051640;biosynthetic process#GO:0009058;macromolecule biosynthetic process#GO:0009059;protein localization to nucleus#GO:0034504;nitrogen compound transport#GO:0071705;macromolecule localization#GO:0033036;import into nucleus#GO:0051170;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;poly(A)+ mRNA export from nucleus#GO:0016973;establishment of protein localization to organelle#GO:0072594;macromolecule metabolic process#GO:0043170;transport#GO:0006810;ribosomal subunit export from nucleus#GO:0000054;RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907;ribonucleoprotein complex biogenesis#GO:0022613;establishment of organelle localization#GO:0051656;ribosomal large subunit export from nucleus#GO:0000055;protein import into nucleus#GO:0006606;protein transport#GO:0015031;cellular localization#GO:0051641;mRNA export from nucleus#GO:0006406;ribosome biogenesis#GO:0042254;protein export from nucleus#GO:0006611;gene expression#GO:0010467;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular component biogenesis#GO:0044085;cellular component organization or biogenesis#GO:0071840;intracellular protein transport#GO:0006886;metabolic process#GO:0008152 organelle envelope#GO:0031967;nucleus#GO:0005634;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nuclear envelope#GO:0005635;intracellular organelle#GO:0043229;nuclear protein-containing complex#GO:0140513;nuclear pore#GO:0005643;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 small GTPase#PC00208 HUMAN|HGNC=33264|UniProtKB=Q6ZWI9 Q6ZWI9 RFPL4B PTHR24103:SF691 E3 UBIQUITIN-PROTEIN LIGASE TRIM RET FINGER PROTEIN-LIKE 4B ubiquitin protein ligase activity#GO:0061630;ubiquitin-like protein transferase activity#GO:0019787;acyltransferase activity#GO:0016746;ubiquitin-like protein ligase activity#GO:0061659;ubiquitin-protein transferase activity#GO:0004842;catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 immune system process#GO:0002376;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;regulation of biological process#GO:0050789;innate immune response#GO:0045087;regulation of biosynthetic process#GO:0009889;response to external stimulus#GO:0009605;defense response#GO:0006952;regulation of gene expression#GO:0010468;defense response to other organism#GO:0098542;biological regulation#GO:0065007;response to other organism#GO:0051707;response to biotic stimulus#GO:0009607;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;response to stress#GO:0006950;defense response to symbiont#GO:0140546;immune response#GO:0006955 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|Ensembl=ENSG00000288190.1|UniProtKB=A0AAG2TVE0 A0AAG2TVE0 PTHR23266:SF359 IMMUNOGLOBULIN HEAVY CHAIN IG-LIKE DOMAIN-CONTAINING PROTEIN binding#GO:0005488;antigen binding#GO:0003823 adaptive immune response#GO:0002250;response to stimulus#GO:0050896;immune response#GO:0006955;immunoglobulin mediated immune response#GO:0016064;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449;immune effector process#GO:0002252;immune system process#GO:0002376 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=17880|UniProtKB=Q8IWU2 Q8IWU2 LMTK2 PTHR24417:SF8 SERINE/THREONINE-PROTEIN KINASE LMTK1 SERINE_THREONINE-PROTEIN KINASE LMTK2 catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 establishment of localization in cell#GO:0051649;cellular process#GO:0009987;endocytic recycling#GO:0032456;vesicle-mediated transport#GO:0016192;localization within membrane#GO:0051668;transport#GO:0006810;intracellular transport#GO:0046907;vesicle-mediated transport to the plasma membrane#GO:0098876;endosomal transport#GO:0016197;localization#GO:0051179;cellular localization#GO:0051641;establishment of localization#GO:0051234 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=15167|UniProtKB=Q6IEV9 Q6IEV9 OR4C11 PTHR48002:SF76 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 4C11 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=22220|UniProtKB=Q6ECI4 Q6ECI4 ZNF470 PTHR24377:SF282 IP01015P-RELATED ZINC FINGER PROTEIN 470 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=3720|UniProtKB=Q02790 Q02790 FKBP4 PTHR10516:SF25 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP4 catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;peptidyl-prolyl cis-trans isomerase activity#GO:0003755;isomerase activity#GO:0016853;cis-trans isomerase activity#GO:0016859 metabolic process#GO:0008152;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;protein folding#GO:0006457 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 chaperone#PC00072 HUMAN|HGNC=744|UniProtKB=Q9UBL3 Q9UBL3 ASH2L PTHR10598:SF0 SET1/ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2 SET1_ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription cis-regulatory region binding#GO:0000976 intracellular organelle lumen#GO:0070013;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;nucleoplasm#GO:0005654;organelle#GO:0043226;methyltransferase complex#GO:0034708;intracellular membrane-bounded organelle#GO:0043231;histone methyltransferase complex#GO:0035097;transferase complex#GO:1990234;Set1C/COMPASS complex#GO:0048188;nuclear protein-containing complex#GO:0140513;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991 chromatin/chromatin-binding, or -regulatory protein#PC00077;histone modifying enzyme#PC00261 HUMAN|HGNC=2394|UniProtKB=P05813 P05813 CRYBA1 PTHR11818:SF8 BETA/GAMMA CRYSTALLIN BETA-CRYSTALLIN A3 structural molecule activity#GO:0005198 multicellular organismal process#GO:0032501;sensory system development#GO:0048880;system process#GO:0003008;animal organ development#GO:0048513;multicellular organism development#GO:0007275;lens development in camera-type eye#GO:0002088;developmental process#GO:0032502;sensory organ development#GO:0007423;visual system development#GO:0150063;visual perception#GO:0007601;sensory perception of light stimulus#GO:0050953;eye development#GO:0001654;system development#GO:0048731;anatomical structure development#GO:0048856;nervous system process#GO:0050877;sensory perception#GO:0007600;animal gross anatomical part developmental process#GO:0160108;camera-type eye development#GO:0043010 structural protein#PC00211 HUMAN|HGNC=8850|UniProtKB=O43933 O43933 PEX1 PTHR23077:SF12 AAA-FAMILY ATPASE PEROXISOMAL ATPASE PEX1 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP-dependent activity#GO:0140657;hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleoside triphosphate phosphatase activity#GO:0017111 transmembrane transport#GO:0055085;cellular localization#GO:0051641;localization#GO:0051179;protein transport#GO:0015031;peroxisomal transport#GO:0043574;peroxisome organization#GO:0007031;protein localization to organelle#GO:0033365;protein import into peroxisome matrix#GO:0016558;cellular component organization#GO:0016043;establishment of localization#GO:0051234;intracellular protein transmembrane transport#GO:0065002;cellular component organization or biogenesis#GO:0071840;establishment of protein localization to organelle#GO:0072594;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;protein transmembrane transport#GO:0071806;transport#GO:0006810;intracellular protein transport#GO:0006886;protein transmembrane import into intracellular organelle#GO:0044743;organelle organization#GO:0006996;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649 organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;peroxisomal membrane#GO:0005778;organelle#GO:0043226;microbody#GO:0042579;membrane#GO:0016020;cytosol#GO:0005829;peroxisome#GO:0005777 primary active transporter#PC00068;transporter#PC00227 HUMAN|HGNC=29222|UniProtKB=Q9H582 Q9H582 ZNF644 PTHR24396:SF25 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 644 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 DNA-binding transcription factor#PC00218;gene-specific transcriptional regulator#PC00264;zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=25295|UniProtKB=Q71RH2 Q71RH2 TLCD3B PTHR13439:SF15 CT120 PROTEIN CERAMIDE SYNTHASE acyltransferase activity#GO:0016746;transferase activity#GO:0016740;catalytic activity#GO:0003824;acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747 ceramide metabolic process#GO:0006672;ceramide biosynthetic process#GO:0046513;lipid metabolic process#GO:0006629;chemical homeostasis#GO:0048878;sphingolipid metabolic process#GO:0006665;metabolic process#GO:0008152;sphingolipid biosynthetic process#GO:0030148;biosynthetic process#GO:0009058;homeostatic process#GO:0042592;lipid biosynthetic process#GO:0008610;cellular process#GO:0009987;lipid homeostasis#GO:0055088;primary metabolic process#GO:0044238 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 transferase#PC00220;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=11187|UniProtKB=Q07889 Q07889 SOS1 PTHR23113:SF168 GUANINE NUCLEOTIDE EXCHANGE FACTOR SON OF SEVENLESS HOMOLOG 1 guanyl-nucleotide exchange factor activity#GO:0005085;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695 intracellular signal transduction#GO:0035556;cell communication#GO:0007154;Ras protein signal transduction#GO:0007265;intracellular signaling cassette#GO:0141124;small GTPase-mediated signal transduction#GO:0007264;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 guanyl-nucleotide exchange factor#PC00113 CCKR signaling map#P06959>SOS1#P07061;B cell activation#P00010>SOS#P00379;Angiogenesis#P00005>SOS-1#P00193;PDGF signaling pathway#P00047>SOS#P01159;EGF receptor signaling pathway#P00018>SOS#P00558;Integrin signalling pathway#P00034>SOS#P00920;PI3 kinase pathway#P00048>SOS#P01185;FGF signaling pathway#P00021>SOS#P00641;Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade#P00032>SOS#P00883;T cell activation#P00053>SOS#P01307;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Sos#P00850;Gonadotropin-releasing hormone receptor pathway#P06664>Sos#P06849;Ras Pathway#P04393>SOS#P04552;Interleukin signaling pathway#P00036>SOS#P00981 HUMAN|HGNC=3250|UniProtKB=P47813 P47813 EIF1AX PTHR21668:SF6 EIF-1A EUKARYOTIC TRANSLATION INITIATION FACTOR 1A, X-CHROMOSOMAL translation factor activity#GO:0180051;translation initiation factor activity#GO:0003743 metabolic process#GO:0008152;translation#GO:0006412;translational initiation#GO:0006413;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;biosynthetic process#GO:0009058 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 translation initiation factor#PC00224;translation factor#PC00223;translational protein#PC00263 HUMAN|HGNC=30013|UniProtKB=Q96PD5 Q96PD5 PGLYRP2 PTHR11022:SF66 PEPTIDOGLYCAN RECOGNITION PROTEIN N-ACETYLMURAMOYL-L-ALANINE AMIDASE catalytic activity#GO:0003824;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;signaling receptor activity#GO:0038023;peptidoglycan muralytic activity#GO:0061783;N-acetylmuramoyl-L-alanine amidase activity#GO:0008745;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811;pattern recognition receptor activity#GO:0038187;molecular transducer activity#GO:0060089;hydrolase activity#GO:0016787 response to external stimulus#GO:0009605;defense response#GO:0006952;immune system process#GO:0002376;response to bacterium#GO:0009617;defense response to bacterium#GO:0042742;response to stimulus#GO:0050896;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to other organism#GO:0051707;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;immune response#GO:0006955;defense response to Gram-positive bacterium#GO:0050830 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090 HUMAN|HGNC=4583|UniProtKB=Q16478 Q16478 GRIK5 PTHR18966:SF351 IONOTROPIC GLUTAMATE RECEPTOR GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 5 transporter activity#GO:0005215;amino acid transmembrane transporter activity#GO:0015171;neurotransmitter receptor activity#GO:0030594;metal ion transmembrane transporter activity#GO:0046873;signaling receptor activity#GO:0038023;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion transmembrane transporter activity#GO:0015075;monoatomic ion channel activity#GO:0005216;gated channel activity#GO:0022836;transmembrane signaling receptor activity#GO:0004888;monoatomic cation transmembrane transporter activity#GO:0008324;transmembrane transporter activity#GO:0022857;sodium channel activity#GO:0005272;ligand-gated monoatomic cation channel activity#GO:0099094;passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;glutamate receptor activity#GO:0008066;sodium ion transmembrane transporter activity#GO:0015081;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;dicarboxylic acid transmembrane transporter activity#GO:0005310;monoatomic cation channel activity#GO:0005261;carboxylic acid transmembrane transporter activity#GO:0046943;ligand-gated monoatomic ion channel activity#GO:0015276;potassium channel activity#GO:0005267;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;molecular transducer activity#GO:0060089 chemical synaptic transmission#GO:0007268;regulation of biological process#GO:0050789;anterograde trans-synaptic signaling#GO:0098916;regulation of cellular process#GO:0050794;modulation of chemical synaptic transmission#GO:0050804;signaling#GO:0023052;regulation of cell communication#GO:0010646;trans-synaptic signaling#GO:0099537;regulation of signaling#GO:0023051;cell communication#GO:0007154;synaptic signaling#GO:0099536;cellular process#GO:0009987;regulation of trans-synaptic signaling#GO:0099177;cell-cell signaling#GO:0007267;synaptic transmission, glutamatergic#GO:0035249;biological regulation#GO:0065007 postsynapse#GO:0098794;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;asymmetric synapse#GO:0032279;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;postsynaptic density#GO:0014069;transmembrane transporter complex#GO:1902495;postsynaptic density membrane#GO:0098839;sodium channel complex#GO:0034706;membrane#GO:0016020;cell periphery#GO:0071944;presynapse#GO:0098793;monoatomic ion channel complex#GO:0034702;neuron to neuron synapse#GO:0098984;protein-containing complex#GO:0032991;plasma membrane region#GO:0098590;postsynaptic specialization#GO:0099572;presynaptic membrane#GO:0042734;plasma membrane#GO:0005886;synaptic membrane#GO:0097060;signaling receptor complex#GO:0043235;cation channel complex#GO:0034703;transporter complex#GO:1990351;cell junction#GO:0030054 transmembrane signal receptor#PC00197 Metabotropic glutamate receptor group I pathway#P00041>GluR5#P01054;Huntington disease#P00029>Kainate receptor#P00796;Metabotropic glutamate receptor group III pathway#P00039>A/K#P01046;Ionotropic glutamate receptor pathway#P00037>A/K#P01025;Ionotropic glutamate receptor pathway#P00037>KA#P01026;Ionotropic glutamate receptor pathway#P00037>KA5#P01000 HUMAN|HGNC=882|UniProtKB=Q13535 Q13535 ATR PTHR11139:SF133 ATAXIA TELANGIECTASIA MUTATED ATM -RELATED SERINE_THREONINE-PROTEIN KINASE ATR kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;transferase activity#GO:0016740;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773 regulation of cell cycle#GO:0051726;signaling#GO:0023052;response to stimulus#GO:0050896;signal transduction in response to DNA damage#GO:0042770;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;negative regulation of cell cycle phase transition#GO:1901988;cellular response to stress#GO:0033554;regulation of cell cycle process#GO:0010564;cell cycle checkpoint signaling#GO:0000075;signal transduction#GO:0007165;cellular process#GO:0009987;organelle organization#GO:0006996;response to stress#GO:0006950;double-strand break repair#GO:0006302;negative regulation of cell cycle#GO:0045786;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;DNA metabolic process#GO:0006259;mitotic cell cycle#GO:0000278;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;cell cycle#GO:0007049;regulation of cell cycle phase transition#GO:1901987;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;telomere organization#GO:0032200;intracellular signal transduction#GO:0035556;cell communication#GO:0007154;nucleobase-containing compound metabolic process#GO:0006139;biological regulation#GO:0065007;DNA damage checkpoint signaling#GO:0000077;DNA integrity checkpoint signaling#GO:0031570;chromosome organization#GO:0051276;telomere maintenance#GO:0000723;macromolecule metabolic process#GO:0043170;DNA damage response#GO:0006974;negative regulation of cell cycle process#GO:0010948;DNA repair#GO:0006281;negative regulation of cellular process#GO:0048523 intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;chromosome#GO:0005694;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 p53 pathway#P00059>ATM/ATR#P01481;p53 pathway feedback loops 2#P04398>ATM#P04669 HUMAN|HGNC=10560|UniProtKB=O15265 O15265 ATXN7 PTHR15117:SF2 ATAXIN 7 RELATED ATAXIN-7 protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 positive regulation of transcription by RNA polymerase II#GO:0045944;microtubule-based process#GO:0007017;regulation of gene expression#GO:0010468;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;organelle organization#GO:0006996;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;cytoskeleton organization#GO:0007010;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of metabolic process#GO:0009893;regulation of DNA-templated transcription#GO:0006355;microtubule cytoskeleton organization#GO:0000226;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;positive regulation of RNA metabolic process#GO:0051254;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=15966|UniProtKB=Q86SG3 Q86SG3 DAZ4 PTHR11176:SF8 BOULE-RELATED DELETED IN AZOOSPERMIA PROTEIN 1-RELATED translation regulator activity#GO:0045182 regulation of mRNA metabolic process#GO:1903311;negative regulation of RNA metabolic process#GO:0051253;mRNA stabilization#GO:0048255;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;regulation of protein metabolic process#GO:0051246;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of biological quality#GO:0065008;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;RNA stabilization#GO:0043489;regulation of translational initiation#GO:0006446;positive regulation of protein metabolic process#GO:0051247;negative regulation of metabolic process#GO:0009892;regulation of mRNA stability#GO:0043488;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;positive regulation of gene expression#GO:0010628;regulation of catabolic process#GO:0009894;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;negative regulation of RNA catabolic process#GO:1902369;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of translation#GO:0006417;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of translation#GO:0045727;negative regulation of catabolic process#GO:0009895;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;regulation of RNA stability#GO:0043487;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 RNA metabolism protein#PC00031 HUMAN|HGNC=4585|UniProtKB=Q12879 Q12879 GRIN2A PTHR18966:SF407 IONOTROPIC GLUTAMATE RECEPTOR GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A monoatomic ion transmembrane transporter activity#GO:0015075;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion channel activity#GO:0005216;signaling receptor activity#GO:0038023;amino acid transmembrane transporter activity#GO:0015171;neurotransmitter receptor activity#GO:0030594;transporter activity#GO:0005215;voltage-gated channel activity#GO:0022832;voltage-gated monoatomic ion channel activity#GO:0005244;transmembrane signaling receptor activity#GO:0004888;gated channel activity#GO:0022836;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;dicarboxylic acid transmembrane transporter activity#GO:0005310;ligand-gated channel activity#GO:0022834;glutamate receptor activity#GO:0008066;passive transmembrane transporter activity#GO:0022803;transmembrane transporter activity#GO:0022857;molecular transducer activity#GO:0060089;channel activity#GO:0015267;carboxylic acid transmembrane transporter activity#GO:0046943;ligand-gated monoatomic ion channel activity#GO:0015276 regulation of membrane potential#GO:0042391;cell surface receptor signaling pathway#GO:0007166;regulation of trans-synaptic signaling#GO:0099177;synaptic transmission, glutamatergic#GO:0035249;synaptic signaling#GO:0099536;cellular process#GO:0009987;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;positive regulation of signaling#GO:0023056;regulation of biological quality#GO:0065008;positive regulation of synaptic transmission#GO:0050806;regulation of signaling#GO:0023051;nervous system process#GO:0050877;response to stimulus#GO:0050896;signaling#GO:0023052;regulation of biological process#GO:0050789;system process#GO:0003008;regulation of synaptic plasticity#GO:0048167;multicellular organismal process#GO:0032501;cell-cell signaling#GO:0007267;biological regulation#GO:0065007;positive regulation of cellular process#GO:0048522;cell communication#GO:0007154;trans-synaptic signaling#GO:0099537;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;anterograde trans-synaptic signaling#GO:0098916;chemical synaptic transmission, postsynaptic#GO:0099565;regulation of cell communication#GO:0010646;modulation of chemical synaptic transmission#GO:0050804;chemical synaptic transmission#GO:0007268;cellular response to stimulus#GO:0051716;regulation of postsynaptic membrane potential#GO:0060078 synaptic membrane#GO:0097060;signaling receptor complex#GO:0043235;cell junction#GO:0030054;transporter complex#GO:1990351;cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;plasma membrane region#GO:0098590;postsynaptic specialization#GO:0099572;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;neuron to neuron synapse#GO:0098984;postsynaptic density#GO:0014069;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;postsynaptic density membrane#GO:0098839;transmembrane transporter complex#GO:1902495;plasma membrane protein complex#GO:0098797;membrane protein complex#GO:0098796;postsynapse#GO:0098794;organelle#GO:0043226;asymmetric synapse#GO:0032279;synapse#GO:0045202;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 Ionotropic glutamate receptor pathway#P00037>NR2C#P01006;Ionotropic glutamate receptor pathway#P00037>NR2B#P01007;Ionotropic glutamate receptor pathway#P00037>NR2A#P01008;Ionotropic glutamate receptor pathway#P00037>NMDA#P01024;Metabotropic glutamate receptor group I pathway#P00041>NMDA#P01060;Huntington disease#P00029>NMDA receptor#P00778;Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>NMDA#P01071;Metabotropic glutamate receptor group III pathway#P00039>NMDA#P01039 HUMAN|HGNC=8535|UniProtKB=Q99571 Q99571 P2RX4 PTHR10125:SF18 P2X PURINOCEPTOR P2X PURINOCEPTOR 4 monoatomic cation channel activity#GO:0005261;monoatomic ion channel activity#GO:0005216;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion transmembrane transporter activity#GO:0015075;excitatory extracellular ligand-gated monoatomic ion channel activity#GO:0005231;ligand-gated monoatomic cation channel activity#GO:0099094;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;ligand-gated channel activity#GO:0022834;passive transmembrane transporter activity#GO:0022803;channel activity#GO:0015267;monoatomic cation transmembrane transporter activity#GO:0008324;gated channel activity#GO:0022836;ligand-gated monoatomic ion channel activity#GO:0015276 monoatomic cation transmembrane transport#GO:0098655;metal ion transport#GO:0030001;monoatomic ion transmembrane transport#GO:0034220;cellular process#GO:0009987;calcium ion transmembrane transport#GO:0070588;calcium ion transport#GO:0006816;monoatomic ion transport#GO:0006811;localization#GO:0051179;monoatomic cation transport#GO:0006812;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;transport#GO:0006810 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 ligand-gated ion channel#PC00141 HUMAN|HGNC=21177|UniProtKB=Q8IYT3 Q8IYT3 CCDC170 PTHR18863:SF4 TSEC-2-RELATED COILED-COIL DOMAIN-CONTAINING PROTEIN 170 protein binding#GO:0005515;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;microtubule binding#GO:0008017 cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization#GO:0016043;cytoskeleton organization#GO:0007010;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;microtubule cytoskeleton organization#GO:0000226 organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=5522|UniProtKB=P01854 P01854 IGHE PTHR23411:SF30 TAPASIN IMMUNOGLOBULIN HEAVY CONSTANT EPSILON antigen binding#GO:0003823;binding#GO:0005488;signaling receptor binding#GO:0005102;protein binding#GO:0005515 biological process involved in interspecies interaction between organisms#GO:0044419;response to stimulus#GO:0050896;regulation of biological process#GO:0050789;immunoglobulin mediated immune response#GO:0016064;adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains#GO:0002460;leukocyte mediated immunity#GO:0002443;lymphocyte mediated immunity#GO:0002449;defense response to bacterium#GO:0042742;immune system process#GO:0002376;defense response to other organism#GO:0098542;activation of immune response#GO:0002253;positive regulation of biological process#GO:0048518;defense response to symbiont#GO:0140546;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;positive regulation of immune system process#GO:0002684;antibacterial humoral response#GO:0019731;immune effector process#GO:0002252;humoral immune response#GO:0006959;antimicrobial humoral response#GO:0019730;response to external biotic stimulus#GO:0043207;regulation of immune system process#GO:0002682;regulation of immune response#GO:0050776;response to bacterium#GO:0009617;biological regulation#GO:0065007;adaptive immune response#GO:0002250;response to other organism#GO:0051707;positive regulation of response to stimulus#GO:0048584;immune response#GO:0006955;complement activation#GO:0006956;response to external stimulus#GO:0009605;defense response#GO:0006952;positive regulation of immune response#GO:0050778;regulation of response to stimulus#GO:0048583 extracellular region#GO:0005576;extracellular protein-containing complex#GO:0140392;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=17176|UniProtKB=Q9NRV9 Q9NRV9 HEBP1 PTHR11220:SF22 HEME-BINDING PROTEIN-RELATED HEME-BINDING PROTEIN 1 binding#GO:0005488;heme binding#GO:0020037;tetrapyrrole binding#GO:0046906 HUMAN|HGNC=13009|UniProtKB=O75362 O75362 ZNF217 PTHR45925:SF4 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 217 DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 C2H2 zinc finger transcription factor#PC00248;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=28482|UniProtKB=Q8WW35 Q8WW35 DYNLT2B PTHR21255:SF7 T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN DYNEIN LIGHT CHAIN TCTEX-TYPE PROTEIN 2B binding#GO:0005488;protein binding#GO:0005515 microtubule-based process#GO:0007017;microtubule-based movement#GO:0007018;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;microtubule associated complex#GO:0005875;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;dynein complex#GO:0030286;cytoplasmic dynein complex#GO:0005868;microtubule cytoskeleton#GO:0015630;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;cytoskeleton#GO:0005856 microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=29827|UniProtKB=O14950 O14950 MYL12B PTHR23049:SF58 MYOSIN REGULATORY LIGHT CHAIN 2 MYOSIN REGULATORY LIGHT CHAIN 12B protein binding#GO:0005515;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;myosin binding#GO:0017022 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;actin filament bundle#GO:0032432;myofibril#GO:0030016;actin cytoskeleton#GO:0015629;cellular anatomical structure#GO:0110165;organelle#GO:0043226;stress fiber#GO:0001725;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;actomyosin#GO:0042641;contractile muscle fiber#GO:0043292;myosin complex#GO:0016459;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080 actin or actin-binding cytoskeletal protein#PC00041;cytoskeletal protein#PC00085 HUMAN|HGNC=53111|UniProtKB=P86397 P86397 HTD2 PTHR43437:SF3 HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL-RELATED HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL catalytic activity#GO:0003824;lyase activity#GO:0016829;carbon-oxygen lyase activity#GO:0016835;hydro-lyase activity#GO:0016836 carboxylic acid biosynthetic process#GO:0046394;cellular process#GO:0009987;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;monocarboxylic acid metabolic process#GO:0032787;biosynthetic process#GO:0009058;fatty acid biosynthetic process#GO:0006633;lipid biosynthetic process#GO:0008610;small molecule metabolic process#GO:0044281;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;fatty acid metabolic process#GO:0006631;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;monocarboxylic acid biosynthetic process#GO:0072330 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 metabolite interconversion enzyme#PC00262;dehydratase#PC00091 HUMAN|HGNC=14256|UniProtKB=Q9ULD4 Q9ULD4 BRPF3 PTHR13793:SF19 PHD FINGER PROTEINS BROMODOMAIN AND PHD FINGER-CONTAINING PROTEIN 3 histone reader activity#GO:0140566;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;chromatin-protein adaptor activity#GO:0140463 regulation of gene expression#GO:0010468;cellular component organization or biogenesis#GO:0071840;regulation of biosynthetic process#GO:0009889;cellular process#GO:0009987;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;chromatin organization#GO:0006325;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;chromatin remodeling#GO:0006338;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794 membrane-bounded organelle#GO:0043227;acetyltransferase complex#GO:1902493;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;protein acetyltransferase complex#GO:0031248;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;chromosome#GO:0005694;histone acetyltransferase complex#GO:0000123;intracellular protein-containing complex#GO:0140535;membraneless organelle#GO:0043228;transferase complex#GO:1990234;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;chromatin#GO:0000785;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;zinc finger transcription factor#PC00244 HUMAN|HGNC=30726|UniProtKB=Q5T0N1 Q5T0N1 CFAP70 PTHR44314:SF1 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 70 CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 70 cilium organization#GO:0044782;cilium movement#GO:0003341;organelle assembly#GO:0070925;microtubule-based movement#GO:0007018;cell projection organization#GO:0030030;cilium assembly#GO:0060271;cellular component organization#GO:0016043;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;plasma membrane bounded cell projection assembly#GO:0120031;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cellular process#GO:0009987;cell projection assembly#GO:0030031;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085 cilium#GO:0005929;motile cilium#GO:0031514;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;membrane-bounded organelle#GO:0043227;plasma membrane bounded cell projection#GO:0120025 structural protein#PC00211 HUMAN|HGNC=2431|UniProtKB=P55060 P55060 CSE1L PTHR10997:SF8 IMPORTIN-7, 8, 11 EXPORTIN-2 molecular carrier activity#GO:0140104;nucleocytoplasmic carrier activity#GO:0140142 establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810;protein export from nucleus#GO:0006611;protein localization to nucleus#GO:0034504;macromolecule localization#GO:0033036;import into nucleus#GO:0051170;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;cellular localization#GO:0051641;localization#GO:0051179;protein import into nucleus#GO:0006606;protein transport#GO:0015031;nuclear export#GO:0051168;nuclear transport#GO:0051169;nucleocytoplasmic transport#GO:0006913;protein localization to organelle#GO:0033365 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;cytosol#GO:0005829;organelle envelope#GO:0031967;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;nuclear envelope#GO:0005635;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226 transporter#PC00227 HUMAN|HGNC=13804|UniProtKB=Q96NK8 Q96NK8 NEUROD6 PTHR19290:SF9 BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED NEUROGENIC DIFFERENTIATION FACTOR 6 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690 regulation of RNA metabolic process#GO:0051252;system development#GO:0048731;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;positive regulation of biosynthetic process#GO:0009891;positive regulation of RNA metabolic process#GO:0051254;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;neurogenesis#GO:0022008;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;developmental process#GO:0032502;sensory organ development#GO:0007423;plasma membrane bounded cell projection organization#GO:0120036;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;positive regulation of DNA-templated transcription#GO:0045893;multicellular organismal process#GO:0032501;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of cellular process#GO:0048522;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;axon development#GO:0061564;regulation of primary metabolic process#GO:0080090;neuron development#GO:0048666;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;generation of neurons#GO:0048699;animal gross anatomical part developmental process#GO:0160108;cell development#GO:0048468;cell projection organization#GO:0030030;cell differentiation#GO:0030154;regulation of transcription by RNA polymerase II#GO:0006357;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;animal organ development#GO:0048513;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;neuron differentiation#GO:0030182;positive regulation of transcription by RNA polymerase II#GO:0045944;nervous system development#GO:0007399;positive regulation of macromolecule metabolic process#GO:0010604;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;neuron projection development#GO:0031175 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=19317|UniProtKB=Q8IVL5 Q8IVL5 P3H2 PTHR14049:SF1 LEPRECAN 1 PROLYL 3-HYDROXYLASE 2 dioxygenase activity#GO:0051213;catalytic activity, acting on a protein#GO:0140096;oxidoreductase activity#GO:0016491;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;catalytic activity#GO:0003824;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705 cellular process#GO:0009987;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 extracellular matrix glycoprotein#PC00100 HUMAN|HGNC=24586|UniProtKB=Q9H1A3 Q9H1A3 METTL9 PTHR12890:SF0 DREV PROTEIN PROTEIN-L-HISTIDINE N-PROS-METHYLTRANSFERASE methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;N-methyltransferase activity#GO:0008170;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring one-carbon groups#GO:0016741;transferase activity#GO:0016740;catalytic activity#GO:0003824;protein methyltransferase activity#GO:0008276 organelle#GO:0043226;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;mitochondrion#GO:0005739;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endoplasmic reticulum#GO:0005783 HUMAN|HGNC=20297|UniProtKB=Q96PX8 Q96PX8 SLITRK1 PTHR45773:SF7 SLIT AND NTRK-LIKE PROTEIN 4-RELATED SLIT AND NTRK-LIKE PROTEIN 1 positive regulation of cellular process#GO:0048522;axon development#GO:0061564;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;regulation of synapse assembly#GO:0051963;multicellular organismal process#GO:0032501;developmental process#GO:0032502;positive regulation of developmental process#GO:0051094;neuron projection morphogenesis#GO:0048812;positive regulation of synapse assembly#GO:0051965;neurogenesis#GO:0022008;cellular developmental process#GO:0048869;regulation of developmental process#GO:0050793;regulation of cellular process#GO:0050794;regulation of cell junction assembly#GO:1901888;system development#GO:0048731;regulation of nervous system development#GO:0051960;regulation of synapse structure or activity#GO:0050803;anatomical structure development#GO:0048856;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;neuron projection development#GO:0031175;nervous system development#GO:0007399;regulation of multicellular organismal process#GO:0051239;cell morphogenesis involved in neuron differentiation#GO:0048667;positive regulation of cellular component biogenesis#GO:0044089;neuron differentiation#GO:0030182;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell projection morphogenesis#GO:0048858;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;regulation of multicellular organismal development#GO:2000026;positive regulation of multicellular organismal process#GO:0051240;cellular component organization#GO:0016043;regulation of cellular component biogenesis#GO:0044087;cell development#GO:0048468;cell projection organization#GO:0030030;regulation of cellular component organization#GO:0051128;positive regulation of nervous system development#GO:0051962;cell differentiation#GO:0030154;cell morphogenesis#GO:0000902;generation of neurons#GO:0048699;positive regulation of cellular component organization#GO:0051130;regulation of synapse organization#GO:0050807;animal gross anatomical part developmental process#GO:0160108;regulation of biological quality#GO:0065008;axonogenesis#GO:0007409;neuron development#GO:0048666 cell junction#GO:0030054;synaptic membrane#GO:0097060;neuron to neuron synapse#GO:0098984;glutamatergic synapse#GO:0098978;postsynaptic specialization#GO:0099572;plasma membrane region#GO:0098590;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;postsynaptic density membrane#GO:0098839;postsynaptic membrane#GO:0045211;postsynaptic specialization membrane#GO:0099634;postsynaptic density#GO:0014069;synapse#GO:0045202;cellular anatomical structure#GO:0110165;organelle#GO:0043226;asymmetric synapse#GO:0032279;GABA-ergic synapse#GO:0098982;postsynapse#GO:0098794 transmembrane signal receptor#PC00197 HUMAN|HGNC=3663|UniProtKB=P98174 P98174 FGD1 PTHR12673:SF79 FACIOGENITAL DYSPLASIA PROTEIN FYVE, RHOGEF AND PH DOMAIN-CONTAINING PROTEIN 1 molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;guanyl-nucleotide exchange factor activity#GO:0005085 plasma membrane bounded cell projection assembly#GO:0120031;cellular component organization or biogenesis#GO:0071840;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular component organization#GO:0016043;cell projection assembly#GO:0030031;cellular process#GO:0009987;filopodium assembly#GO:0046847;cell projection organization#GO:0030030;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection organization#GO:0120036 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 G-protein modulator#PC00022;guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=16988|UniProtKB=Q9BRL6 Q9BRL6 SRSF8 PTHR23147:SF14 SERINE/ARGININE RICH SPLICING FACTOR SERINE_ARGININE-RICH SPLICING FACTOR 8 nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;nuclear body#GO:0016604;intracellular membraneless organelle#GO:0043232;supramolecular complex#GO:0099080;ribonucleoprotein granule#GO:0035770;membraneless organelle#GO:0043228;nuclear speck#GO:0016607;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 RNA splicing factor#PC00148;RNA metabolism protein#PC00031;RNA processing factor#PC00147 HUMAN|HGNC=11752|UniProtKB=P19532 P19532 TFE3 PTHR45776:SF3 MIP04163P TRANSCRIPTION FACTOR E3 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218;basic helix-loop-helix transcription factor#PC00055 HUMAN|HGNC=29926|UniProtKB=Q9Y2X3 Q9Y2X3 NOP58 PTHR10894:SF1 NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58 NUCLEOLAR PROTEIN 58 binding#GO:0005488;snoRNA binding#GO:0030515;nucleic acid binding#GO:0003676;RNA binding#GO:0003723 intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;ribonucleoprotein complex#GO:1990904;preribosome#GO:0030684;intracellular organelle#GO:0043229;sno(s)RNA-containing ribonucleoprotein complex#GO:0005732;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;small-subunit processome#GO:0032040;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232 RNA metabolism protein#PC00031 HUMAN|HGNC=33176|UniProtKB=Q5MJ09 Q5MJ09 SPANXN3 PTHR23425:SF7 NUCLEOPORIN AMO1-LIKE SPERM PROTEIN ASSOCIATED WITH THE NUCLEUS ON THE X CHROMOSOME N2-RELATED transporter#PC00227 HUMAN|HGNC=29527|UniProtKB=Q9Y241 Q9Y241 HIGD1A PTHR12297:SF5 HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED HIG1 DOMAIN FAMILY MEMBER 1A, MITOCHONDRIAL regulation of biological process#GO:0050789;protein-containing complex assembly#GO:0065003;regulation of programmed cell death#GO:0043067;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;regulation of cellular process#GO:0050794;negative regulation of programmed cell death#GO:0043069;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;mitochondrial respiratory chain complex assembly#GO:0033108;mitochondrion organization#GO:0007005;biological regulation#GO:0065007;negative regulation of apoptotic process#GO:0043066;cellular component assembly#GO:0022607;regulation of apoptotic process#GO:0042981;negative regulation of cellular process#GO:0048523;protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840 mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HUMAN|HGNC=10691|UniProtKB=P20132 P20132 SDS PTHR48078:SF8 THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED L-SERINE DEHYDRATASE_L-THREONINE DEAMINASE lyase activity#GO:0016829;catalytic activity#GO:0003824 branched-chain amino acid biosynthetic process#GO:0009082;small molecule biosynthetic process#GO:0044283;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;amino acid biosynthetic process#GO:0008652;proteinogenic amino acid biosynthetic process#GO:0170038;carboxylic acid biosynthetic process#GO:0046394;aspartate family amino acid biosynthetic process#GO:0009067;cellular process#GO:0009987;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;small molecule metabolic process#GO:0044281;proteinogenic amino acid metabolic process#GO:0170039 dehydratase#PC00091;lyase#PC00144 HUMAN|HGNC=28002|UniProtKB=Q495B1 Q495B1 ANKDD1A PTHR24125:SF0 ANKYRIN REPEAT AND DEATH DOMAIN-CONTAINING PROTEIN ANKYRIN REPEAT AND DEATH DOMAIN-CONTAINING PROTEIN 1A HUMAN|HGNC=18285|UniProtKB=Q96S21 Q96S21 RAB40C PTHR47980:SF2 LD44762P RAS-RELATED PROTEIN RAB-40C enzyme-substrate adaptor activity#GO:0140767;molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 vesicle-mediated transport#GO:0016192;proteasomal protein catabolic process#GO:0010498;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;establishment of localization#GO:0051234;exocytosis#GO:0006887;ubiquitin-dependent protein catabolic process#GO:0006511;metabolic process#GO:0008152;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule catabolic process#GO:0009057;transport#GO:0006810;catabolic process#GO:0009056;export from cell#GO:0140352;primary metabolic process#GO:0044238;modification-dependent protein catabolic process#GO:0019941;localization#GO:0051179;protein metabolic process#GO:0019538;secretion#GO:0046903;secretion by cell#GO:0032940;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;plasma membrane#GO:0005886;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cell periphery#GO:0071944;vesicle#GO:0031982;membrane#GO:0016020;intracellular vesicle#GO:0097708;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endosome#GO:0005768;intracellular organelle#GO:0043229 HUMAN|HGNC=23026|UniProtKB=Q9UJJ9 Q9UJJ9 GNPTG PTHR12630:SF6 N-LINKED OLIGOSACCHARIDE PROCESSING N-ACETYLGLUCOSAMINE-1-PHOSPHOTRANSFERASE SUBUNIT GAMMA glycoprotein biosynthetic process#GO:0009101;primary metabolic process#GO:0044238;protein N-linked glycosylation#GO:0006487;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;biosynthetic process#GO:0009058;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;macromolecule metabolic process#GO:0043170;carbohydrate derivative biosynthetic process#GO:1901137;protein metabolic process#GO:0019538 organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum protein-containing complex#GO:0140534;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;endoplasmic reticulum#GO:0005783 protein-binding activity modulator#PC00095 HUMAN|HGNC=16966|UniProtKB=Q15326 Q15326 ZMYND11 PTHR46379:SF1 ZINC FINGER MYND DOMAIN-CONTAINING ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 11 chromatin-protein adaptor activity#GO:0140463;histone H3 reader activity#GO:0140006;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;histone reader activity#GO:0140566 cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;transcription by RNA polymerase II#GO:0006366;gene expression#GO:0010467;transcription elongation by RNA polymerase II#GO:0006368;chromatin organization#GO:0006325;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;DNA-templated transcription elongation#GO:0006354;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;RNA metabolic process#GO:0016070;nucleic acid biosynthetic process#GO:0141187;RNA biosynthetic process#GO:0032774;DNA-templated transcription#GO:0006351;chromatin remodeling#GO:0006338;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cellular component organization#GO:0016043 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 transcription cofactor#PC00217;gene-specific transcriptional regulator#PC00264 HUMAN|HGNC=17035|UniProtKB=Q96B26 Q96B26 EXOSC8 PTHR11097:SF9 EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN EXOSOME COMPLEX COMPONENT RRP43 mRNA 3'-UTR binding#GO:0003730;RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729 rRNA metabolic process#GO:0016072;negative regulation of cellular process#GO:0048523;regulation of biosynthetic process#GO:0009889;nuclear-transcribed mRNA catabolic process#GO:0000956;macromolecule metabolic process#GO:0043170;regulation of gene expression#GO:0010468;snRNA processing#GO:0016180;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;nucleobase-containing compound catabolic process#GO:0034655;macromolecule biosynthetic process#GO:0009059;nucleic acid catabolic process#GO:0141188;negative regulation of macromolecule metabolic process#GO:0010605;nuclear mRNA surveillance#GO:0071028;biosynthetic process#GO:0009058;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;snRNA metabolic process#GO:0016073;rRNA processing#GO:0006364;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of cellular process#GO:0050794;catabolic process#GO:0009056;regulation of macromolecule metabolic process#GO:0060255;RNA biosynthetic process#GO:0032774;macromolecule catabolic process#GO:0009057;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;metabolic process#GO:0008152;cellular component organization or biogenesis#GO:0071840;RNA 3'-end processing#GO:0031123;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;mRNA catabolic process#GO:0006402;cellular process#GO:0009987;gene expression#GO:0010467;RNA processing#GO:0006396;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;RNA catabolic process#GO:0006401;RNA metabolic process#GO:0016070;negative regulation of gene expression#GO:0010629;maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)#GO:0000466;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;snRNA 3'-end processing#GO:0034472;ribonucleoprotein complex biogenesis#GO:0022613;negative regulation of metabolic process#GO:0009892;maturation of 5.8S rRNA#GO:0000460;mRNA metabolic process#GO:0016071 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular organelle lumen#GO:0070013 exoribonuclease#PC00099;RNA metabolism protein#PC00031 HUMAN|HGNC=13441|UniProtKB=Q8IWY4 Q8IWY4 SCUBE1 PTHR24046:SF4 SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 1 cellular developmental process#GO:0048869;developmental process#GO:0032502;response to BMP#GO:0071772;cellular response to BMP stimulus#GO:0071773;cell surface receptor signaling pathway#GO:0007166;cell surface receptor protein serine/threonine kinase signaling pathway#GO:0007178;biological regulation#GO:0065007;transforming growth factor beta receptor superfamily signaling pathway#GO:0141091;signal transduction#GO:0007165;cellular process#GO:0009987;smoothened signaling pathway#GO:0007224;cellular response to growth factor stimulus#GO:0071363;cell communication#GO:0007154;enzyme-linked receptor protein signaling pathway#GO:0007167;anatomical structure development#GO:0048856;animal gross anatomical part developmental process#GO:0160108;signaling#GO:0023052;cell development#GO:0048468;cell differentiation#GO:0030154;cellular response to endogenous stimulus#GO:0071495;response to growth factor#GO:0070848;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;muscle structure development#GO:0061061;muscle cell differentiation#GO:0042692;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;BMP signaling pathway#GO:0030509;muscle cell development#GO:0055001;response to endogenous stimulus#GO:0009719 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;extracellular region#GO:0005576;membrane#GO:0016020 extracellular matrix glycoprotein#PC00100 HUMAN|HGNC=26632|UniProtKB=Q6P9A3 Q6P9A3 ZNF549 PTHR24377:SF690 IP01015P-RELATED ZINC FINGER PROTEIN 549 transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=1336|UniProtKB=Q9NYF3 Q9NYF3 FAM53C PTHR28567:SF4 PROTEIN FAM53A-LIKE ISOFORM X1 PROTEIN FAM53C intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;establishment of protein localization to organelle#GO:0072594;transport#GO:0006810;intracellular protein transport#GO:0006886;intracellular transport#GO:0046907;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;protein localization to nucleus#GO:0034504;import into nucleus#GO:0051170;macromolecule localization#GO:0033036;protein import into nucleus#GO:0006606;protein transport#GO:0015031;nuclear transport#GO:0051169;cellular localization#GO:0051641;localization#GO:0051179;nucleocytoplasmic transport#GO:0006913;protein localization to organelle#GO:0033365 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 HUMAN|HGNC=32016|UniProtKB=P0C7M7 P0C7M7 ACSM4 PTHR43605:SF8 ACYL-COENZYME A SYNTHETASE ACYL-COENZYME A SYNTHETASE ACSM4, MITOCHONDRIAL acyltransferase activity, transferring groups other than amino-acyl groups#GO:0016747;ligase activity#GO:0016874;ATP-dependent activity#GO:0140657;acyltransferase activity#GO:0016746;ligase activity, forming carbon-sulfur bonds#GO:0016877;catalytic activity#GO:0003824;transferase activity#GO:0016740 oxoacid metabolic process#GO:0043436;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;carboxylic acid biosynthetic process#GO:0046394;purine-containing compound metabolic process#GO:0072521;phosphorus metabolic process#GO:0006793;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;monocarboxylic acid metabolic process#GO:0032787;nucleobase-containing small molecule metabolic process#GO:0055086;acyl-CoA metabolic process#GO:0006637;monocarboxylic acid biosynthetic process#GO:0072330;small molecule biosynthetic process#GO:0044283;lipid metabolic process#GO:0006629;fatty acid metabolic process#GO:0006631;metabolic process#GO:0008152;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;fatty acid biosynthetic process#GO:0006633;lipid biosynthetic process#GO:0008610;cellular process#GO:0009987;sulfur compound metabolic process#GO:0006790;organophosphate metabolic process#GO:0019637 mitochondrion#GO:0005739;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;mitochondrial matrix#GO:0005759;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 ligase#PC00142;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=4199|UniProtKB=Q92616 Q92616 GCN1 PTHR23346:SF7 TRANSLATIONAL ACTIVATOR GCN1-RELATED STALLED RIBOSOME SENSOR GCN1 protein kinase regulator activity#GO:0019887;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;enzyme regulator activity#GO:0030234 biological regulation#GO:0065007;cellular response to amino acid starvation#GO:0034198;cellular process#GO:0009987;regulation of protein metabolic process#GO:0051246;response to stress#GO:0006950;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;response to nutrient levels#GO:0031667;regulation of translation#GO:0006417;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular response to nutrient levels#GO:0031669;post-transcriptional regulation of gene expression#GO:0010608;cellular response to starvation#GO:0009267;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of macromolecule metabolic process#GO:0060255;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;response to starvation#GO:0042594;cellular response to stress#GO:0033554 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 scaffold/adaptor protein#PC00226 HUMAN|HGNC=1694|UniProtKB=Q07108 Q07108 CD69 PTHR45710:SF35 C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN 180 EARLY ACTIVATION ANTIGEN CD69 molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545 immune response-activating signaling pathway#GO:0002757;regulation of response to stimulus#GO:0048583;cell surface receptor signaling pathway#GO:0007166;positive regulation of immune response#GO:0050778;T cell receptor signaling pathway#GO:0050852;immune response-regulating cell surface receptor signaling pathway#GO:0002768;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;lymphocyte activation#GO:0046649;antigen receptor-mediated signaling pathway#GO:0050851;positive regulation of response to stimulus#GO:0048584;cellular process#GO:0009987;activation of immune response#GO:0002253;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;positive regulation of immune system process#GO:0002684;cell communication#GO:0007154;cell activation#GO:0001775;regulation of immune response#GO:0050776;immune system process#GO:0002376;immune response-activating cell surface receptor signaling pathway#GO:0002429;signaling#GO:0023052;regulation of immune system process#GO:0002682;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;immune response-regulating signaling pathway#GO:0002764;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;T cell activation#GO:0042110;leukocyte activation#GO:0045321 plasma membrane#GO:0005886;cell surface#GO:0009986;side of membrane#GO:0098552;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020 defense/immunity protein#PC00090 HUMAN|HGNC=25472|UniProtKB=Q8N4H0 Q8N4H0 SPATA6L PTHR16435:SF5 SPERMATOGENESIS-ASSOCIATED PROTEIN 6 SPATA6 SPERMATOGENESIS ASSOCIATED 6-LIKE PROTEIN HUMAN|HGNC=15322|UniProtKB=Q8NGQ1 Q8NGQ1 OR9G4 PTHR48018:SF129 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 9G4 olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;signaling#GO:0023052;sensory perception of smell#GO:0007608;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;nervous system process#GO:0050877;sensory perception#GO:0007600;G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;cellular process#GO:0009987;signal transduction#GO:0007165;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;sensory perception of chemical stimulus#GO:0007606;system process#GO:0003008 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=4273|UniProtKB=Q14161 Q14161 GIT2 PTHR46097:SF4 G PROTEIN-COUPLED RECEPTOR KINASE INTERACTING ARFGAP ARF GTPASE-ACTIVATING PROTEIN GIT2 molecular function regulator activity#GO:0098772;GTPase activator activity#GO:0005096;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;protein binding#GO:0005515;small GTPase binding#GO:0031267;enzyme regulator activity#GO:0030234;enzyme binding#GO:0019899;binding#GO:0005488 regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;nervous system development#GO:0007399;head development#GO:0060322;brain development#GO:0007420;multicellular organismal process#GO:0032501;vesicle-mediated transport#GO:0016192;synaptic vesicle recycling#GO:0036465;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;regulation of small GTPase mediated signal transduction#GO:0051056;multicellular organism development#GO:0007275;vesicle-mediated transport in synapse#GO:0099003;establishment of localization#GO:0051234;animal organ development#GO:0048513;developmental process#GO:0032502;transport#GO:0006810;regulation of response to stimulus#GO:0048583;synaptic vesicle cycle#GO:0099504;regulation of G protein-coupled receptor signaling pathway#GO:0008277;regulation of cell communication#GO:0010646;central nervous system development#GO:0007417;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;system development#GO:0048731;localization#GO:0051179;cellular localization#GO:0051641;anatomical structure development#GO:0048856;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;animal gross anatomical part developmental process#GO:0160108 synapse#GO:0045202;cellular anatomical structure#GO:0110165;cell junction#GO:0030054 HUMAN|HGNC=14313|UniProtKB=Q8WYA0 Q8WYA0 IFT81 PTHR15614:SF2 INTRAFLAGELLAR TRANSPORT PROTEIN 81 HOMOLOG INTRAFLAGELLAR TRANSPORT PROTEIN 81 HOMOLOG cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631;binding#GO:0005488;protein binding#GO:0005515 microtubule-based transport#GO:0099111;localization#GO:0051179;cellular localization#GO:0051641;cilium organization#GO:0044782;cellular component organization#GO:0016043;cell projection organization#GO:0030030;microtubule-based movement#GO:0007018;intraciliary transport#GO:0042073;intracellular transport#GO:0046907;transport#GO:0006810;cellular component organization or biogenesis#GO:0071840;establishment of localization#GO:0051234;transport along microtubule#GO:0010970;microtubule-based process#GO:0007017;organelle organization#GO:0006996;establishment of localization in cell#GO:0051649;cellular process#GO:0009987;cytoskeleton-dependent intracellular transport#GO:0030705;plasma membrane bounded cell projection organization#GO:0120036 plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cilium#GO:0005929;intraciliary transport particle#GO:0030990;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;intraciliary transport particle B#GO:0030992;cytoskeleton#GO:0005856;ciliary basal body#GO:0036064;microtubule organizing center#GO:0005815 HUMAN|HGNC=728|UniProtKB=O00192 O00192 ARVCF PTHR10372:SF5 PLAKOPHILLIN-RELATED SPLICING REGULATOR ARVCF cell adhesion molecule binding#GO:0050839;binding#GO:0005488;protein binding#GO:0005515 cell-cell adhesion#GO:0098609;cell adhesion#GO:0007155;cellular process#GO:0009987 cell junction#GO:0030054;membrane-bounded organelle#GO:0043227;adherens junction#GO:0005912;anchoring junction#GO:0070161;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cell-cell junction#GO:0005911;membrane#GO:0016020;cell periphery#GO:0071944;nucleus#GO:0005634 intermediate filament binding protein#PC00130;intermediate filament#PC00129;cytoskeletal protein#PC00085 HUMAN|HGNC=14959|UniProtKB=Q96T37 Q96T37 RBM15 PTHR23189:SF43 RNA RECOGNITION MOTIF-CONTAINING RNA-BINDING PROTEIN 15 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729 regulation of RNA splicing#GO:0043484;biological regulation#GO:0065007;regulation of mRNA processing#GO:0050684;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of gene expression#GO:0010468;regulation of mRNA metabolic process#GO:1903311;regulation of biosynthetic process#GO:0009889;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of mRNA splicing, via spliceosome#GO:0048024;regulation of biological process#GO:0050789;regulation of RNA metabolic process#GO:0051252;regulation of alternative mRNA splicing, via spliceosome#GO:0000381 RNA metabolism protein#PC00031 HUMAN|HGNC=2552|UniProtKB=Q13617 Q13617 CUL2 PTHR11932:SF174 CULLIN CULLIN-2 ubiquitin-like protein ligase binding#GO:0044389;binding#GO:0005488;protein complex scaffold activity#GO:0140378;enzyme binding#GO:0019899;protein binding#GO:0005515;structural molecule activity#GO:0005198;ubiquitin protein ligase binding#GO:0031625 metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;cellular process#GO:0009987;protein ubiquitination#GO:0016567;proteasomal protein catabolic process#GO:0010498;post-translational protein modification#GO:0043687;protein modification by small protein conjugation or removal#GO:0070647;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;macromolecule modification#GO:0043412;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;protein modification process#GO:0036211;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056 transferase complex#GO:1990234;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;membrane-bounded organelle#GO:0043227;ubiquitin ligase complex#GO:0000151;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;SCF ubiquitin ligase complex#GO:0019005;cullin-RING ubiquitin ligase complex#GO:0031461;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=30300|UniProtKB=Q9GZS3 Q9GZS3 SKIC8 PTHR44090:SF1 WD REPEAT-CONTAINING PROTEIN 61 SUPERKILLER COMPLEX PROTEIN 8 transferase complex, transferring phosphorus-containing groups#GO:0061695;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;RNA polymerase II, holoenzyme#GO:0016591;DNA-directed RNA polymerase complex#GO:0000428;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle lumen#GO:0043233;nuclear DNA-directed RNA polymerase complex#GO:0055029;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleoplasm#GO:0005654;intracellular membrane-bounded organelle#GO:0043231;transcription elongation factor complex#GO:0008023;Cdc73/Paf1 complex#GO:0016593;transferase complex#GO:1990234;nuclear protein-containing complex#GO:0140513;intracellular protein-containing complex#GO:0140535;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;RNA polymerase complex#GO:0030880;protein-containing complex#GO:0032991 HUMAN|HGNC=14487|UniProtKB=O75394 O75394 MRPL33 PTHR47037:SF1 39S RIBOSOMAL PROTEIN L33, MITOCHONDRIAL LARGE RIBOSOMAL SUBUNIT PROTEIN BL33M mitochondrion#GO:0005739;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 ribosomal protein#PC00202 HUMAN|HGNC=5881|UniProtKB=A0A075B6I6 A0A075B6I6 IGLV1-50 PTHR23267:SF535 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN LAMBDA VARIABLE 1-40-RELATED response to stimulus#GO:0050896;immune system process#GO:0002376;immune response#GO:0006955 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=8604|UniProtKB=O95340 O95340 PAPSS2 PTHR11055:SF16 BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE 2 phosphotransferase activity, alcohol group as acceptor#GO:0016773;transferase activity#GO:0016740;catalytic activity#GO:0003824;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772 purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;phosphorus metabolic process#GO:0006793;primary metabolic process#GO:0044238;nucleoside phosphate metabolic process#GO:0006753;small molecule metabolic process#GO:0044281;purine nucleotide biosynthetic process#GO:0006164;oxoacid metabolic process#GO:0043436;purine-containing compound biosynthetic process#GO:0072522;ribonucleotide metabolic process#GO:0009259;nucleotide biosynthetic process#GO:0009165;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;organophosphate biosynthetic process#GO:0090407;carbohydrate derivative metabolic process#GO:1901135;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;ribonucleotide biosynthetic process#GO:0009260;organophosphate metabolic process#GO:0019637;ribose phosphate biosynthetic process#GO:0046390;sulfur compound metabolic process#GO:0006790;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing small molecule metabolic process#GO:0055086;nucleoside phosphate biosynthetic process#GO:1901293;carbohydrate derivative biosynthetic process#GO:1901137 Sulfate assimilation#P02778>Sulfate adenylyltransferase#P03167 HUMAN|HGNC=6924|UniProtKB=Q15012 Q15012 LAPTM4A PTHR12479:SF5 LYSOSOMAL-ASSOCIATED TRANSMEMBRANE PROTEIN LYSOSOMAL-ASSOCIATED TRANSMEMBRANE PROTEIN 4A biological regulation#GO:0065007;regulation of biological quality#GO:0065008;regulation of membrane permeability#GO:0090559 lysosome#GO:0005764;lytic vacuole membrane#GO:0098852;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;lysosomal membrane#GO:0005765;membrane#GO:0016020;vacuole#GO:0005773;cytoplasm#GO:0005737;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;lytic vacuole#GO:0000323;vacuolar membrane#GO:0005774 transporter#PC00227 HUMAN|HGNC=3069|UniProtKB=P51452 P51452 DUSP3 PTHR45682:SF1 AGAP008228-PA DUAL SPECIFICITY PROTEIN PHOSPHATASE 3 catalytic activity#GO:0003824;protein tyrosine/serine/threonine phosphatase activity#GO:0008138;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;phosphoprotein phosphatase activity#GO:0004721 regulation of MAPK cascade#GO:0043408;regulation of JNK cascade#GO:0046328;positive regulation of biological process#GO:0048518;regulation of T cell activation#GO:0050863;negative regulation of cell-cell adhesion#GO:0022408;regulation of ERK1 and ERK2 cascade#GO:0070372;negative regulation of ERK1 and ERK2 cascade#GO:0070373;regulation of multicellular organismal process#GO:0051239;positive regulation of cell cycle#GO:0045787;negative regulation of lymphocyte activation#GO:0051250;negative regulation of signal transduction#GO:0009968;negative regulation of leukocyte activation#GO:0002695;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;regulation of signaling#GO:0023051;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;regulation of leukocyte activation#GO:0002694;negative regulation of biological process#GO:0048519;regulation of cell activation#GO:0050865;regulation of biological process#GO:0050789;regulation of lymphocyte activation#GO:0051249;regulation of cell cycle#GO:0051726;negative regulation of cellular process#GO:0048523;regulation of leukocyte cell-cell adhesion#GO:1903037;regulation of response to stimulus#GO:0048583;negative regulation of cell activation#GO:0050866;positive regulation of mitotic cell cycle#GO:0045931;regulation of mitotic cell cycle#GO:0007346;positive regulation of cellular process#GO:0048522;negative regulation of response to stimulus#GO:0048585;regulation of cell adhesion#GO:0030155;negative regulation of cell adhesion#GO:0007162;negative regulation of immune system process#GO:0002683;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of immune response#GO:0050776;negative regulation of T cell activation#GO:0050868;negative regulation of multicellular organismal process#GO:0051241;negative regulation of MAPK cascade#GO:0043409;regulation of immune system process#GO:0002682;regulation of cell-cell adhesion#GO:0022407;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;negative regulation of leukocyte cell-cell adhesion#GO:1903038 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cytosol#GO:0005829 protein phosphatase#PC00195 Oxidative stress response#P00046>MKP5#P01131 HUMAN|HGNC=25844|UniProtKB=Q9H898 Q9H898 ZMAT4 PTHR46144:SF3 ZINC FINGER PROTEIN 385B-LIKE ZINC FINGER MATRIN-TYPE PROTEIN 4 HUMAN|HGNC=4380|UniProtKB=Q03113 Q03113 GNA12 PTHR10218:SF130 GTP-BINDING PROTEIN ALPHA SUBUNIT GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-12 molecular function regulator activity#GO:0098772;ribonucleoside triphosphate phosphatase activity#GO:0017111;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817;G protein-coupled receptor binding#GO:0001664;protein binding#GO:0005515;hydrolase activity#GO:0016787;GTPase activity#GO:0003924;binding#GO:0005488;signaling receptor binding#GO:0005102;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818 intracellular signal transduction#GO:0035556;Rho protein signal transduction#GO:0007266;cell communication#GO:0007154;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;G protein-coupled receptor signaling pathway#GO:0007186;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;small GTPase-mediated signal transduction#GO:0007264;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789 plasma membrane region#GO:0098590;brush border membrane#GO:0031526;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;cytoplasm#GO:0005737;membrane#GO:0016020;brush border#GO:0005903;cell periphery#GO:0071944;extrinsic component of membrane#GO:0019898;extrinsic component of plasma membrane#GO:0019897;apical part of cell#GO:0045177;cytoplasmic side of membrane#GO:0098562;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;plasma membrane bounded cell projection#GO:0120025;apical plasma membrane#GO:0016324;membrane protein complex#GO:0098796;cytoplasmic side of plasma membrane#GO:0009898;plasma membrane protein complex#GO:0098797;cell projection membrane#GO:0031253;side of membrane#GO:0098552;cluster of actin-based cell projections#GO:0098862;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;extrinsic component of cytoplasmic side of plasma membrane#GO:0031234 G-protein#PC00020;heterotrimeric G-protein#PC00117 HUMAN|HGNC=18133|UniProtKB=Q9H2K8 Q9H2K8 TAOK3 PTHR48015:SF14 SERINE/THREONINE-PROTEIN KINASE TAO SERINE_THREONINE-PROTEIN KINASE TAO3 protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;transferase activity#GO:0016740;catalytic activity#GO:0003824 MAPK cascade#GO:0000165;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of cell communication#GO:0010646;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;regulation of MAPK cascade#GO:0043408;regulation of response to stimulus#GO:0048583;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;intracellular signaling cassette#GO:0141124;signal transduction#GO:0007165;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=11764|UniProtKB=P01266 P01266 TG PTHR14093:SF19 HLA CLASS II GAMMA CHAIN THYROGLOBULIN metabolic process#GO:0008152;regulation of biological quality#GO:0065008;phenol-containing compound metabolic process#GO:0018958;regulation of hormone levels#GO:0010817;cellular process#GO:0009987;modified amino acid metabolic process#GO:0006575;biological regulation#GO:0065007;hormone metabolic process#GO:0042445 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=11194|UniProtKB=P35713 P35713 SOX18 PTHR10270:SF204 SOX TRANSCRIPTION FACTOR TRANSCRIPTION FACTOR SOX-18 sequence-specific DNA binding#GO:0043565;DNA-binding transcription activator activity, RNA polymerase II-specific#GO:0001228;transcription regulatory region nucleic acid binding#GO:0001067;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;DNA-binding transcription activator activity#GO:0001216;transcription regulator activity#GO:0140110;sequence-specific double-stranded DNA binding#GO:1990837;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976 system development#GO:0048731;regulation of RNA metabolic process#GO:0051252;positive regulation of biosynthetic process#GO:0009891;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;blood vessel development#GO:0001568;tube morphogenesis#GO:0035239;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;developmental process#GO:0032502;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;tube development#GO:0035295;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of cellular process#GO:0048522;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;angiogenesis#GO:0001525;animal gross anatomical part developmental process#GO:0160108;regulation of transcription by RNA polymerase II#GO:0006357;circulatory system development#GO:0072359;cell differentiation#GO:0030154;regulation of biological process#GO:0050789;anatomical structure morphogenesis#GO:0009653;blood vessel morphogenesis#GO:0048514;vasculature development#GO:0001944;anatomical structure formation involved in morphogenesis#GO:0048646;multicellular organism development#GO:0007275;positive regulation of transcription by RNA polymerase II#GO:0045944;vasculogenesis#GO:0001570;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;cellular process#GO:0009987 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218;HMG box transcription factor#PC00024 HUMAN|HGNC=3070|UniProtKB=Q13115 Q13115 DUSP4 PTHR10159:SF111 DUAL SPECIFICITY PROTEIN PHOSPHATASE DUAL SPECIFICITY PROTEIN PHOSPHATASE 4 hydrolase activity#GO:0016787;protein tyrosine phosphatase activity#GO:0004725;phosphoprotein phosphatase activity#GO:0004721;protein tyrosine/serine/threonine phosphatase activity#GO:0008138;catalytic activity#GO:0003824;phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;phosphoric ester hydrolase activity#GO:0042578;catalytic activity, acting on a protein#GO:0140096 negative regulation of signaling#GO:0023057;animal gross anatomical part developmental process#GO:0160108;regulation of intracellular signal transduction#GO:1902531;formation of primary germ layer#GO:0001704;regulation of signaling#GO:0023051;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;negative regulation of biological process#GO:0048519;gastrulation#GO:0007369;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;signaling#GO:0023052;regulation of MAPK cascade#GO:0043408;multicellular organism development#GO:0007275;embryonic morphogenesis#GO:0048598;endoderm development#GO:0007492;anatomical structure formation involved in morphogenesis#GO:0048646;signal transduction#GO:0007165;cellular process#GO:0009987;negative regulation of signal transduction#GO:0009968;endoderm formation#GO:0001706;embryo development#GO:0009790;cell communication#GO:0007154;anatomical structure development#GO:0048856;cellular response to stimulus#GO:0051716;negative regulation of MAPK cascade#GO:0043409;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;regulation of response to stimulus#GO:0048583;multicellular organismal process#GO:0032501;negative regulation of response to stimulus#GO:0048585;tissue development#GO:0009888;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007 nucleus#GO:0005634;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 protein phosphatase#PC00195 Oxidative stress response#P00046>MKP5#P01131 HUMAN|HGNC=30362|UniProtKB=Q8IVN8 Q8IVN8 SBSPON PTHR20920:SF2 RPE-SPONDIN SOMATOMEDIN-B AND THROMBOSPONDIN TYPE-1 DOMAIN-CONTAINING PROTEIN HUMAN|HGNC=20823|UniProtKB=Q8N608 Q8N608 DPP10 PTHR11731:SF21 PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED INACTIVE DIPEPTIDYL PEPTIDASE 10 catalytic activity#GO:0003824;ion channel regulator activity#GO:0099106;peptidase activity#GO:0008233;molecular function regulator activity#GO:0098772;catalytic activity, acting on a protein#GO:0140096;transporter regulator activity#GO:0141108;potassium channel regulator activity#GO:0015459;channel regulator activity#GO:0016247;exopeptidase activity#GO:0008238;hydrolase activity#GO:0016787 regulation of transmembrane transport#GO:0034762;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of metal ion transport#GO:0010959;proteolysis#GO:0006508;protein metabolic process#GO:0019538;cellular process#GO:0009987;regulation of monoatomic ion transmembrane transport#GO:0034765;regulation of monoatomic ion transport#GO:0043269;biological regulation#GO:0065007;metabolic process#GO:0008152;regulation of monoatomic cation transmembrane transport#GO:1904062;macromolecule metabolic process#GO:0043170;regulation of localization#GO:0032879;regulation of transport#GO:0051049 transporter complex#GO:1990351;transmembrane transporter complex#GO:1902495;voltage-gated potassium channel complex#GO:0008076;cation channel complex#GO:0034703;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944 serine protease#PC00203;protease#PC00190 HUMAN|HGNC=5419|UniProtKB=A0A087WWS6 A0A087WWS6 IFNA13 PTHR11691:SF64 TYPE I INTERFERON INTERFERON ALPHA-1-RELATED signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;cytokine activity#GO:0005125;cytokine receptor binding#GO:0005126;binding#GO:0005488;signaling receptor binding#GO:0005102;molecular function activator activity#GO:0140677;protein-containing complex binding#GO:0044877;protein binding#GO:0005515 cellular response to stimulus#GO:0051716;leukocyte activation#GO:0045321;response to external biotic stimulus#GO:0043207;regulation of cellular process#GO:0050794;cell activation#GO:0001775;cytokine-mediated signaling pathway#GO:0019221;response to nitrogen compound#GO:1901698;cell communication#GO:0007154;immune response#GO:0006955;response to other organism#GO:0051707;adaptive immune response#GO:0002250;biological regulation#GO:0065007;multicellular organismal process#GO:0032501;defense response#GO:0006952;response to external stimulus#GO:0009605;innate immune response#GO:0045087;cellular response to cytokine stimulus#GO:0071345;regulation of biological process#GO:0050789;T cell activation#GO:0042110;biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052;response to stimulus#GO:0050896;type I interferon-mediated signaling pathway#GO:0060337;B cell activation involved in immune response#GO:0002312;immune system process#GO:0002376;response to peptide#GO:1901652;cell activation involved in immune response#GO:0002263;cellular process#GO:0009987;lymphocyte activation involved in immune response#GO:0002285;signal transduction#GO:0007165;defense response to symbiont#GO:0140546;response to stress#GO:0006950;response to biotic stimulus#GO:0009607;T cell activation involved in immune response#GO:0002286;defense response to other organism#GO:0098542;response to chemical#GO:0042221;response to cytokine#GO:0034097;lymphocyte activation#GO:0046649;cell surface receptor signaling pathway#GO:0007166;natural killer cell activation#GO:0030101;immune effector process#GO:0002252;leukocyte activation involved in immune response#GO:0002366;humoral immune response#GO:0006959;B cell activation#GO:0042113 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 cytokine#PC00083;interferon superfamily#PC00127 HUMAN|HGNC=23189|UniProtKB=Q8TBB0 Q8TBB0 THAP6 PTHR47577:SF1 THAP DOMAIN-CONTAINING PROTEIN 6 THAP DOMAIN-CONTAINING PROTEIN 6 HUMAN|HGNC=29520|UniProtKB=Q86WP2 Q86WP2 GPBP1 PTHR14339:SF11 VASCULIN VASCULIN transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700 biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=24496|UniProtKB=Q6NW34 Q6NW34 RMP64 PTHR34761:SF1 NUCLEOLUS AND NEURAL PROGENITOR PROTEIN RIBONUCLEASE MRP SUBUNIT P64 regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;regulation of cell communication#GO:0010646;positive regulation of Notch signaling pathway#GO:0045747;positive regulation of response to stimulus#GO:0048584;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;positive regulation of signaling#GO:0023056;regulation of response to stimulus#GO:0048583;regulation of Notch signaling pathway#GO:0008593;regulation of signaling#GO:0023051 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 HUMAN|HGNC=25574|UniProtKB=Q9BVG3 Q9BVG3 TRIM62 PTHR24103:SF573 E3 UBIQUITIN-PROTEIN LIGASE TRIM E3 UBIQUITIN-PROTEIN LIGASE TRIM62 ubiquitin-like protein transferase activity#GO:0019787;ubiquitin protein ligase activity#GO:0061630;acyltransferase activity#GO:0016746;ubiquitin-protein transferase activity#GO:0004842;ubiquitin-like protein ligase activity#GO:0061659;catalytic activity#GO:0003824;transferase activity#GO:0016740;aminoacyltransferase activity#GO:0016755;catalytic activity, acting on a protein#GO:0140096 regulation of biological process#GO:0050789;positive regulation of signal transduction#GO:0009967;response to external biotic stimulus#GO:0043207;biological process involved in interspecies interaction between organisms#GO:0044419;regulation of cell communication#GO:0010646;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of signaling#GO:0023051;immune system process#GO:0002376;regulation of intracellular signal transduction#GO:1902531;positive regulation of signaling#GO:0023056;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;immune response#GO:0006955;defense response to symbiont#GO:0140546;regulation of canonical NF-kappaB signal transduction#GO:0043122;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;response to other organism#GO:0051707;positive regulation of response to stimulus#GO:0048584;defense response to other organism#GO:0098542;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;response to external stimulus#GO:0009605;defense response#GO:0006952;innate immune response#GO:0045087;positive regulation of canonical NF-kappaB signal transduction#GO:0043123 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 protein modifying enzyme#PC00260;ubiquitin-protein ligase#PC00234 HUMAN|HGNC=15469|UniProtKB=O75061 O75061 DNAJC6 PTHR23172:SF4 AUXILIN/CYCLIN G-ASSOCIATED KINASE-RELATED AUXILIN clathrin binding#GO:0030276;binding#GO:0005488;protein binding#GO:0005515 vesicle-mediated transport#GO:0016192;synaptic vesicle recycling#GO:0036465;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;protein-containing complex organization#GO:0043933;receptor-mediated endocytosis#GO:0006898;establishment of localization#GO:0051234;vesicle-mediated transport in synapse#GO:0099003;import into cell#GO:0098657;cellular component organization or biogenesis#GO:0071840;transport#GO:0006810;synaptic vesicle cycle#GO:0099504;protein-containing complex disassembly#GO:0032984;endocytosis#GO:0006897;clathrin-dependent endocytosis#GO:0072583;cellular component organization#GO:0016043;synaptic vesicle endocytosis#GO:0048488;cellular component disassembly#GO:0022411;cellular localization#GO:0051641;localization#GO:0051179 postsynapse#GO:0098794;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;synapse#GO:0045202;neuron to neuron synapse#GO:0098984;organelle#GO:0043226;postsynaptic specialization#GO:0099572;asymmetric synapse#GO:0032279;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;postsynaptic density#GO:0014069;intracellular organelle#GO:0043229;cell junction#GO:0030054;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 membrane traffic protein#PC00150 HUMAN|HGNC=30482|UniProtKB=Q5VZ03 Q5VZ03 NXNL2 PTHR46762:SF1 NUCLEOREDOXIN-LIKE PROTEIN 2 NUCLEOREDOXIN-LIKE PROTEIN 2 system process#GO:0003008;sensory perception of chemical stimulus#GO:0007606;nervous system process#GO:0050877;sensory perception#GO:0007600;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;visual perception#GO:0007601;sensory perception of light stimulus#GO:0050953 oxidoreductase#PC00176;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=4092|UniProtKB=Q99259 Q99259 GAD1 PTHR45677:SF5 GLUTAMATE DECARBOXYLASE-RELATED GLUTAMATE DECARBOXYLASE 1 carboxy-lyase activity#GO:0016831;catalytic activity#GO:0003824;carbon-carbon lyase activity#GO:0016830;lyase activity#GO:0016829 biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;small molecule metabolic process#GO:0044281;cellular process#GO:0009987;carboxylic acid biosynthetic process#GO:0046394;carboxylic acid metabolic process#GO:0019752;primary metabolic process#GO:0044238;small molecule biosynthetic process#GO:0044283;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;amino acid biosynthetic process#GO:0008652 presynapse#GO:0098793;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cell junction#GO:0030054;synapse#GO:0045202;presynaptic active zone#GO:0048786;cellular anatomical structure#GO:0110165 decarboxylase#PC00089;metabolite interconversion enzyme#PC00262 Gamma-aminobutyric acid synthesis#P04384>Glutamate decarboxylase#P04482 HUMAN|HGNC=24258|UniProtKB=Q96E29 Q96E29 MTERF3 PTHR13068:SF194 CGI-12 PROTEIN-RELATED TRANSCRIPTION TERMINATION FACTOR 3, MITOCHONDRIAL negative regulation of cellular process#GO:0048523;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;mitochondrial ribosome assembly#GO:0061668;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;organelle assembly#GO:0070925;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;cellular component organization or biogenesis#GO:0071840;negative regulation of macromolecule biosynthetic process#GO:0010558;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cellular component assembly#GO:0022607;ribosome assembly#GO:0042255;ribosome biogenesis#GO:0042254;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of biological process#GO:0048519;cellular component organization#GO:0016043;membraneless organelle assembly#GO:0140694;regulation of biological process#GO:0050789;negative regulation of metabolic process#GO:0009892;ribonucleoprotein complex biogenesis#GO:0022613 mitochondrion#GO:0005739;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=18662|UniProtKB=Q9Y2V3 Q9Y2V3 RAX PTHR46271:SF3 HOMEOBOX PROTEIN, PUTATIVE-RELATED RETINAL HOMEOBOX PROTEIN RX sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676 regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 homeodomain transcription factor#PC00119 HUMAN|HGNC=6296|UniProtKB=O43526 O43526 KCNQ2 PTHR11537:SF6 VOLTAGE-GATED POTASSIUM CHANNEL POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 2 voltage-gated monoatomic cation channel activity#GO:0022843;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;monoatomic cation transmembrane transporter activity#GO:0008324;voltage-gated channel activity#GO:0022832;voltage-gated potassium channel activity#GO:0005249;gated channel activity#GO:0022836;voltage-gated monoatomic ion channel activity#GO:0005244;monoatomic cation channel activity#GO:0005261;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;channel activity#GO:0015267;potassium ion transmembrane transporter activity#GO:0015079;potassium channel activity#GO:0005267 regulation of biological quality#GO:0065008;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;action potential#GO:0001508;metal ion transport#GO:0030001;transport#GO:0006810;regulation of membrane potential#GO:0042391;establishment of localization#GO:0051234;cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;biological regulation#GO:0065007;potassium ion transmembrane transport#GO:0071805;potassium ion transport#GO:0006813 cation channel complex#GO:0034703;voltage-gated potassium channel complex#GO:0008076;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;membrane protein complex#GO:0098796;membrane#GO:0016020;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;monoatomic ion channel complex#GO:0034702;plasma membrane#GO:0005886 voltage-gated ion channel#PC00241;ion channel#PC00133 Muscarinic acetylcholine receptor 1 and 3 signaling pathway#P00042>K+ channel#P01070 HUMAN|HGNC=8918|UniProtKB=P78562 P78562 PHEX PTHR11733:SF133 ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED PHOSPHATE-REGULATING NEUTRAL ENDOPEPTIDASE PHEX endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;metalloendopeptidase activity#GO:0004222;catalytic activity, acting on a protein#GO:0140096;hydrolase activity#GO:0016787;metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824 primary metabolic process#GO:0044238;protein processing#GO:0016485;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;gene expression#GO:0010467;protein maturation#GO:0051604;biosynthetic process#GO:0009058;proteolysis#GO:0006508;metabolic process#GO:0008152;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 protease#PC00190;metalloprotease#PC00153 HUMAN|HGNC=12711|UniProtKB=O75436 O75436 VPS26A PTHR12233:SF4 VACUOLAR PROTEIN SORTING 26 RELATED VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 26A cytosolic transport#GO:0016482;cellular localization#GO:0051641;localization#GO:0051179;protein transport#GO:0015031;retrograde transport, endosome to Golgi#GO:0042147;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of localization in cell#GO:0051649;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;transport#GO:0006810;intracellular protein transport#GO:0006886;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;endosomal transport#GO:0016197 endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular vesicle#GO:0097708;membrane protein complex#GO:0098796;retromer complex#GO:0030904;vesicle#GO:0031982;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;membrane#GO:0016020;protein-containing complex#GO:0032991;endomembrane system#GO:0012505;cytoplasm#GO:0005737 membrane traffic protein#PC00150 HUMAN|HGNC=23514|UniProtKB=Q8N7W2 Q8N7W2 BEND7 PTHR35068:SF1 BEN DOMAIN-CONTAINING PROTEIN 7 BEN DOMAIN-CONTAINING PROTEIN 7 hemostasis#GO:0007599;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;regulation of body fluid levels#GO:0050878;signaling#GO:0023052;immune system process#GO:0002376;cell activation#GO:0001775;cell communication#GO:0007154;regulation of biological quality#GO:0065008;wound healing#GO:0042060;response to stress#GO:0006950;response to wounding#GO:0009611;coagulation#GO:0050817;immune response#GO:0006955;cellular process#GO:0009987;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;cell-cell signaling#GO:0007267;platelet activation#GO:0030168;blood coagulation#GO:0007596 HUMAN|HGNC=9675|UniProtKB=P28827 P28827 PTPRM PTHR19134:SF206 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE MU phosphatase activity#GO:0016791;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;phosphoprotein phosphatase activity#GO:0004721;protein tyrosine phosphatase activity#GO:0004725;hydrolase activity#GO:0016787 anatomical structure development#GO:0048856;cell communication#GO:0007154;neuron development#GO:0048666;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;regulation of cellular process#GO:0050794;cell projection organization#GO:0030030;response to stimulus#GO:0050896;cell differentiation#GO:0030154;cell development#GO:0048468;signaling#GO:0023052;cellular component organization#GO:0016043;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;neurogenesis#GO:0022008;developmental process#GO:0032502;neuron differentiation#GO:0030182;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;biological regulation#GO:0065007;neuron projection development#GO:0031175;cellular process#GO:0009987;signal transduction#GO:0007165 protein phosphatase#PC00195;protein modifying enzyme#PC00260 HUMAN|HGNC=8097|UniProtKB=Q9UMX2 Q9UMX2 OAZ3 PTHR10279:SF9 ORNITHINE DECARBOXYLASE ANTIZYME ORNITHINE DECARBOXYLASE ANTIZYME 3 enzyme inhibitor activity#GO:0004857;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;molecular function inhibitor activity#GO:0140678 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634 protein-binding activity modulator#PC00095 HUMAN|HGNC=14947|UniProtKB=Q9BZL4 Q9BZL4 PPP1R12C PTHR24179:SF27 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12 PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12C phosphatase regulator activity#GO:0019208;enzyme regulator activity#GO:0030234;molecular function regulator activity#GO:0098772;molecular function inhibitor activity#GO:0140678;protein phosphatase regulator activity#GO:0019888;enzyme inhibitor activity#GO:0004857 cell morphogenesis#GO:0000902;cell projection organization#GO:0030030;cell differentiation#GO:0030154;cell development#GO:0048468;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;anatomical structure development#GO:0048856;neuron development#GO:0048666;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;plasma membrane bounded cell projection organization#GO:0120036;neuron projection development#GO:0031175;cellular process#GO:0009987;cellular developmental process#GO:0048869;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;neurogenesis#GO:0022008;cell projection morphogenesis#GO:0048858;plasma membrane bounded cell projection morphogenesis#GO:0120039;neuron projection morphogenesis#GO:0048812;developmental process#GO:0032502;neuron differentiation#GO:0030182 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 phosphatase modulator#PC00184;protein-binding activity modulator#PC00095 HUMAN|HGNC=18789|UniProtKB=Q9Y247 Q9Y247 FAM50B PTHR12722:SF1 XAP-5 PROTEIN-RELATED PROTEIN FAM50B chromatin organization#GO:0006325;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;cellular component organization#GO:0016043 intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 HUMAN|HGNC=50800|UniProtKB=Q9UBX2 Q9UBX2 DUX4 PTHR46123:SF3 MIX-TYPE HOMEOBOX GENE 1-RELATED DOUBLE HOMEOBOX PROTEIN 1-RELATED nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 helix-turn-helix transcription factor#PC00116;homeodomain transcription factor#PC00119 HUMAN|HGNC=24256|UniProtKB=Q9Y3C0 Q9Y3C0 WASHC3 PTHR13015:SF2 PROTEIN AD-016-RELATED WASH COMPLEX SUBUNIT 3 establishment of localization#GO:0051234;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;exocytosis#GO:0006887;actin filament organization#GO:0007015;transport#GO:0006810;vesicle-mediated transport#GO:0016192;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;actin polymerization or depolymerization#GO:0008154;cellular process#GO:0009987;secretion#GO:0046903;localization#GO:0051179;secretion by cell#GO:0032940;supramolecular fiber organization#GO:0097435;actin filament-based process#GO:0030029;actin cytoskeleton organization#GO:0030036;actin filament polymerization#GO:0030041;export from cell#GO:0140352;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;protein polymerization#GO:0051258 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=21054|UniProtKB=Q86UC2 Q86UC2 RSPH3 PTHR21648:SF0 FLAGELLAR RADIAL SPOKE PROTEIN 3 RADIAL SPOKE HEAD PROTEIN 3 HOMOLOG cilium#GO:0005929;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cell projection#GO:0042995;membrane-bounded organelle#GO:0043227;plasma membrane bounded cell projection#GO:0120025 structural protein#PC00211 HUMAN|HGNC=25547|UniProtKB=Q9P209 Q9P209 CEP72 PTHR23311:SF7 HEAT SHOCK REGULATED 2 CENTROSOMAL PROTEIN OF 72 KDA centriole replication#GO:0007099;organelle assembly#GO:0070925;regulation of protein localization#GO:0032880;microtubule cytoskeleton organization#GO:0000226;centrosome cycle#GO:0007098;regulation of biological process#GO:0050789;cell cycle process#GO:0022402;cell cycle#GO:0007049;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;microtubule organizing center organization#GO:0031023;regulation of localization#GO:0032879;centrosome duplication#GO:0051298;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;spindle organization#GO:0007051;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cytoskeleton organization#GO:0007010;biological regulation#GO:0065007;cellular component assembly#GO:0022607 microtubule cytoskeleton#GO:0015630;intracellular membraneless organelle#GO:0043232;centriolar satellite#GO:0034451;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;microtubule organizing center#GO:0005815;centrosome#GO:0005813;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 HUMAN|HGNC=16912|UniProtKB=Q92979 Q92979 EMG1 PTHR12636:SF5 NEP1/MRA1 RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE NEP1 RNA binding#GO:0003723;catalytic activity, acting on a rRNA#GO:0140102;nucleic acid binding#GO:0003676;binding#GO:0005488;methyltransferase activity#GO:0008168;S-adenosylmethionine-dependent methyltransferase activity#GO:0008757;rRNA methyltransferase activity#GO:0008649;RNA methyltransferase activity#GO:0008173;catalytic activity, acting on RNA#GO:0140098;catalytic activity#GO:0003824;rRNA binding#GO:0019843;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741;catalytic activity, acting on a nucleic acid#GO:0140640 metabolic process#GO:0008152;rRNA metabolic process#GO:0016072;nucleobase-containing compound biosynthetic process#GO:0034654;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;rRNA methylation#GO:0031167;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;rRNA base methylation#GO:0070475;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;biosynthetic process#GO:0009058;RNA processing#GO:0006396;nucleobase-containing compound metabolic process#GO:0006139;ribosome biogenesis#GO:0042254;nucleic acid biosynthetic process#GO:0141187;macromolecule methylation#GO:0043414;RNA modification#GO:0009451;methylation#GO:0032259;RNA methylation#GO:0001510;RNA metabolic process#GO:0016070;macromolecule modification#GO:0043412;rRNA processing#GO:0006364;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;rRNA modification#GO:0000154;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;ribonucleoprotein complex#GO:1990904;nucleolus#GO:0005730;intracellular organelle lumen#GO:0070013;preribosome#GO:0030684;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;small-subunit processome#GO:0032040;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634 methyltransferase#PC00155;transferase#PC00220 HUMAN|HGNC=13286|UniProtKB=Q6PIW4 Q6PIW4 FIGNL1 PTHR23074:SF75 AAA DOMAIN-CONTAINING FIDGETIN-LIKE PROTEIN 1 catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;macromolecular conformation isomerase activity#GO:0120543;hydrolase activity, acting on acid anhydrides#GO:0016817;catalytic activity, acting on a protein#GO:0140096;ribonucleoside triphosphate phosphatase activity#GO:0017111;isomerase activity#GO:0016853;polypeptide conformation or assembly isomerase activity#GO:0120544;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;ATP-dependent activity#GO:0140657;hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887 microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 microtubule or microtubule-binding cytoskeletal protein#PC00157;non-motor microtubule binding protein#PC00166 HUMAN|HGNC=20096|UniProtKB=Q96BM1 Q96BM1 ANKRD9 PTHR24133:SF16 ANKYRIN DOMAIN-CONTAINING ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 9 scaffold/adaptor protein#PC00226 HUMAN|HGNC=8546|UniProtKB=P13674 P13674 P4HA1 PTHR10869:SF101 PROLYL 4-HYDROXYLASE ALPHA SUBUNIT PROLYL 4-HYDROXYLASE SUBUNIT ALPHA-1 dioxygenase activity#GO:0051213;oxidoreductase activity#GO:0016491;catalytic activity, acting on a protein#GO:0140096;2-oxoglutarate-dependent dioxygenase activity#GO:0016706;oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen#GO:0016705;catalytic activity#GO:0003824 extracellular matrix organization#GO:0030198;collagen fibril organization#GO:0030199;cellular component organization or biogenesis#GO:0071840;external encapsulating structure organization#GO:0045229;cellular component organization#GO:0016043;extracellular structure organization#GO:0043062;cellular process#GO:0009987 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;oxidoreductase complex#GO:1990204;intracellular anatomical structure#GO:0005622;endoplasmic reticulum protein-containing complex#GO:0140534;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;catalytic complex#GO:1902494 protein modifying enzyme#PC00260 HUMAN|HGNC=19902|UniProtKB=Q9HB90 Q9HB90 RRAGC PTHR11259:SF6 RAS-RELATED GTP BINDING RAG/GTR YEAST RAS-RELATED GTP-BINDING PROTEIN C catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;ribonucleoside triphosphate phosphatase activity#GO:0017111;nucleotide binding#GO:0000166;small molecule binding#GO:0036094;anion binding#GO:0043168;GTPase activity#GO:0003924;ion binding#GO:0043167;hydrolase activity#GO:0016787;ribonucleotide binding#GO:0032553;hydrolase activity, acting on acid anhydrides#GO:0016817;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;guanyl nucleotide binding#GO:0019001;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;nucleoside phosphate binding#GO:1901265;GTP binding#GO:0005525;guanyl ribonucleotide binding#GO:0032561 positive regulation of signal transduction#GO:0009967;response to starvation#GO:0042594;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;regulation of cell communication#GO:0010646;positive regulation of TOR signaling#GO:0032008;negative regulation of catabolic process#GO:0009895;positive regulation of TORC1 signaling#GO:1904263;regulation of metabolic process#GO:0019222;response to nutrient levels#GO:0031667;positive regulation of cellular process#GO:0048522;positive regulation of response to stimulus#GO:0048584;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;cellular response to starvation#GO:0009267;regulation of response to stimulus#GO:0048583;cellular response to nutrient levels#GO:0031669;positive regulation of intracellular signal transduction#GO:1902533;regulation of catabolic process#GO:0009894;negative regulation of autophagy#GO:0010507;regulation of TORC1 signaling#GO:1903432;negative regulation of biological process#GO:0048519;regulation of autophagy#GO:0010506;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;negative regulation of metabolic process#GO:0009892;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;cellular response to stress#GO:0033554;positive regulation of signaling#GO:0023056;response to stress#GO:0006950;cellular process#GO:0009987;regulation of TOR signaling#GO:0032006;positive regulation of biological process#GO:0048518 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;vacuole#GO:0005773;lysosome#GO:0005764;nucleus#GO:0005634;lytic vacuole#GO:0000323;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;catalytic complex#GO:1902494 small GTPase#PC00208 HUMAN|HGNC=23409|UniProtKB=Q6UWR7 Q6UWR7 ENPP6 PTHR10151:SF66 ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE GLYCEROPHOSPHOCHOLINE CHOLINEPHOSPHODIESTERASE ENPP6 hydrolase activity#GO:0016787;phosphoric diester hydrolase activity#GO:0008081;phosphoric ester hydrolase activity#GO:0042578;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788 metabolic process#GO:0008152;primary metabolic process#GO:0044238;lipid metabolic process#GO:0006629;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 hydrolase#PC00121;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=1157|UniProtKB=Q13895 Q13895 BYSL PTHR12821:SF0 BYSTIN BYSTIN snoRNA binding#GO:0030515;nucleic acid binding#GO:0003676;binding#GO:0005488;RNA binding#GO:0003723 macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;gene expression#GO:0010467;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;rRNA metabolic process#GO:0016072;macromolecule metabolic process#GO:0043170;cellular component organization or biogenesis#GO:0071840;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;ribonucleoprotein complex biogenesis#GO:0022613;nucleic acid biosynthetic process#GO:0141187;ribosome biogenesis#GO:0042254;rRNA processing#GO:0006364;RNA metabolic process#GO:0016070 membraneless organelle#GO:0043228;protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;nucleolus#GO:0005730;preribosome#GO:0030684;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233 HUMAN|HGNC=1606|UniProtKB=P51681 P51681 CCR5 PTHR10489:SF960 CELL ADHESION MOLECULE C-C CHEMOKINE RECEPTOR TYPE 5 binding#GO:0005488;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;protein binding#GO:0005515;cytokine receptor activity#GO:0004896;immune receptor activity#GO:0140375;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023;cytokine binding#GO:0019955 cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;cell motility#GO:0048870;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;locomotion#GO:0040011;signaling#GO:0023052;cellular response to chemical stimulus#GO:0070887;immune system process#GO:0002376;positive regulation of cytosolic calcium ion concentration#GO:0007204;inflammatory response#GO:0006954;chemotaxis#GO:0006935;cell communication#GO:0007154;regulation of biological quality#GO:0065008;intracellular signal transduction#GO:0035556;cell chemotaxis#GO:0060326;response to stress#GO:0006950;cellular process#GO:0009987;signal transduction#GO:0007165;immune response#GO:0006955;cell migration#GO:0016477;response to chemical#GO:0042221;taxis#GO:0042330;intracellular signaling cassette#GO:0141124;biological regulation#GO:0065007;defense response#GO:0006952;calcium-mediated signaling#GO:0019722;response to external stimulus#GO:0009605 external side of plasma membrane#GO:0009897;side of membrane#GO:0098552;intracellular anatomical structure#GO:0005622;membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;cytoplasm#GO:0005737;plasma membrane#GO:0005886 cell adhesion molecule#PC00069 Inflammation mediated by chemokine and cytokine signaling pathway#P00031>CHKR#P00854 HUMAN|HGNC=22213|UniProtKB=Q9ULD5 Q9ULD5 ZNF777 PTHR24377:SF972 IP01015P-RELATED ZINC FINGER PROTEIN 777 transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=4760|UniProtKB=Q16778 Q16778 H2BC21 PTHR23428:SF322 HISTONE H2B HISTONE H2B TYPE 2-E defense response to symbiont#GO:0140546;immune response#GO:0006955;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;response to other organism#GO:0051707;defense response to other organism#GO:0098542;humoral immune response#GO:0006959;antimicrobial humoral response#GO:0019730;response to external stimulus#GO:0009605;defense response#GO:0006952;antibacterial humoral response#GO:0019731;innate immune response#GO:0045087;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;response to stimulus#GO:0050896;defense response to bacterium#GO:0042742;response to bacterium#GO:0009617;immune system process#GO:0002376;antimicrobial humoral immune response mediated by antimicrobial peptide#GO:0061844 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=21094|UniProtKB=Q5JW98 Q5JW98 CALHM4 PTHR32261:SF5 CALCIUM HOMEOSTASIS MODULATOR PROTEIN CALCIUM HOMEOSTASIS MODULATOR PROTEIN 4 monoatomic cation channel activity#GO:0005261;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;passive transmembrane transporter activity#GO:0022803;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;monoatomic cation transmembrane transporter activity#GO:0008324;channel activity#GO:0015267 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 voltage-gated ion channel#PC00241 HUMAN|HGNC=3358|UniProtKB=O14638 O14638 ENPP3 PTHR10151:SF107 ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE ECTONUCLEOTIDE PYROPHOSPHATASE_PHOSPHODIESTERASE FAMILY MEMBER 3 pyrophosphatase activity#GO:0016462;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;hydrolase activity, acting on acid anhydrides#GO:0016817;nucleoside triphosphate diphosphatase activity#GO:0047429;hydrolase activity#GO:0016787 catabolic process#GO:0009056;regulation of cellular process#GO:0050794;regulation of immune system process#GO:0002682;regulation of response to biotic stimulus#GO:0002831;nucleoside triphosphate metabolic process#GO:0009141;regulation of cell communication#GO:0010646;negative regulation of biological process#GO:0048519;phosphorus metabolic process#GO:0006793;regulation of biological process#GO:0050789;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of cell communication#GO:0010648;negative regulation of signaling#GO:0023057;regulation of intracellular signal transduction#GO:1902531;regulation of immune response#GO:0050776;regulation of defense response#GO:0031347;regulation of signaling#GO:0023051;regulation of response to external stimulus#GO:0032101;negative regulation of response to stimulus#GO:0048585;negative regulation of immune system process#GO:0002683;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;negative regulation of signal transduction#GO:0009968;cellular process#GO:0009987;regulation of innate immune response#GO:0045088;metabolic process#GO:0008152;negative regulation of cellular process#GO:0048523;regulation of response to stress#GO:0080134;regulation of response to stimulus#GO:0048583 cell periphery#GO:0071944;external side of plasma membrane#GO:0009897;membrane#GO:0016020;plasma membrane#GO:0005886;cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 HUMAN|HGNC=24502|UniProtKB=O43379 O43379 WDR62 PTHR45589:SF3 WD REPEAT DOMAIN 62, ISOFORM G WD REPEAT-CONTAINING PROTEIN 62 regulation of biological process#GO:0050789;regulation of mitotic cell cycle#GO:0007346;regulation of cellular process#GO:0050794;regulation of cell cycle#GO:0051726;biological regulation#GO:0065007 organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitotic spindle#GO:0072686;intracellular membraneless organelle#GO:0043232;microtubule cytoskeleton#GO:0015630;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;spindle#GO:0005819;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229 HUMAN|HGNC=22958|UniProtKB=Q9NR12 Q9NR12 PDLIM7 PTHR24214:SF0 PDZ AND LIM DOMAIN PROTEIN ZASP PDZ AND LIM DOMAIN PROTEIN 7 protein binding#GO:0005515;actin binding#GO:0003779;cytoskeletal protein binding#GO:0008092;binding#GO:0005488 multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;animal organ development#GO:0048513;developmental process#GO:0032502;heart development#GO:0007507;multicellular organismal process#GO:0032501;cytoskeleton organization#GO:0007010;organelle organization#GO:0006996;cellular process#GO:0009987;anatomical structure development#GO:0048856;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;actin filament-based process#GO:0030029;circulatory system development#GO:0072359;muscle structure development#GO:0061061;actin cytoskeleton organization#GO:0030036;cellular component organization#GO:0016043 supramolecular fiber#GO:0099512;anchoring junction#GO:0070161;intracellular anatomical structure#GO:0005622;actin filament bundle#GO:0032432;myofibril#GO:0030016;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;actin cytoskeleton#GO:0015629;adherens junction#GO:0005912;sarcomere#GO:0030017;cell junction#GO:0030054;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;I band#GO:0031674;actin filament#GO:0005884;cytoskeleton#GO:0005856;stress fiber#GO:0001725;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;contractile muscle fiber#GO:0043292;actomyosin#GO:0042641;Z disc#GO:0030018;cell-cell junction#GO:0005911 actin or actin-binding cytoskeletal protein#PC00041 HUMAN|HGNC=10519|UniProtKB=Q9NZJ4 Q9NZJ4 SACS PTHR15600:SF44 SACSIN SACSIN Hsp70 protein binding#GO:0030544;protein binding#GO:0005515;heat shock protein binding#GO:0031072;binding#GO:0005488;protein-folding chaperone binding#GO:0051087 HUMAN|HGNC=30762|UniProtKB=A6H8Z2 A6H8Z2 FAM221B PTHR31214:SF3 PROTEIN FAM221A-RELATED PROTEIN FAM221B HUMAN|HGNC=7098|UniProtKB=Q07325 Q07325 CXCL9 PTHR12015:SF210 SMALL INDUCIBLE CYTOKINE A C-X-C MOTIF CHEMOKINE 9 cytokine activity#GO:0005125;cytokine receptor binding#GO:0005126;signaling receptor binding#GO:0005102;binding#GO:0005488;chemokine receptor binding#GO:0042379;protein binding#GO:0005515;molecular function activator activity#GO:0140677;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;chemokine activity#GO:0008009;G protein-coupled receptor binding#GO:0001664;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546 neutrophil chemotaxis#GO:0030593;cell surface receptor signaling pathway#GO:0007166;response to lipopolysaccharide#GO:0032496;response to stress#GO:0006950;cellular response to lipopolysaccharide#GO:0071222;response to biotic stimulus#GO:0009607;response to chemokine#GO:1990868;cellular process#GO:0009987;cellular response to oxygen-containing compound#GO:1901701;signal transduction#GO:0007165;response to lipid#GO:0033993;granulocyte migration#GO:0097530;cellular response to lipid#GO:0071396;neutrophil migration#GO:1990266;taxis#GO:0042330;response to cytokine#GO:0034097;response to chemical#GO:0042221;cellular response to chemical stimulus#GO:0070887;immune system process#GO:0002376;G protein-coupled receptor signaling pathway#GO:0007186;response to oxygen-containing compound#GO:1901700;response to peptide#GO:1901652;regulation of biological process#GO:0050789;cellular response to cytokine stimulus#GO:0071345;response to molecule of bacterial origin#GO:0002237;response to stimulus#GO:0050896;granulocyte chemotaxis#GO:0071621;biological process involved in interspecies interaction between organisms#GO:0044419;signaling#GO:0023052;leukocyte migration#GO:0050900;cellular response to molecule of bacterial origin#GO:0071219;defense response#GO:0006952;leukocyte chemotaxis#GO:0030595;response to external stimulus#GO:0009605;myeloid leukocyte migration#GO:0097529;cell migration#GO:0016477;response to other organism#GO:0051707;biological regulation#GO:0065007;response to bacterium#GO:0009617;cytokine-mediated signaling pathway#GO:0019221;inflammatory response#GO:0006954;chemotaxis#GO:0006935;cell communication#GO:0007154;chemokine-mediated signaling pathway#GO:0070098;cell chemotaxis#GO:0060326;cellular response to biotic stimulus#GO:0071216;cellular response to stimulus#GO:0051716;cell motility#GO:0048870;regulation of cellular process#GO:0050794;cellular response to chemokine#GO:1990869;locomotion#GO:0040011;response to external biotic stimulus#GO:0043207 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 cytokine#PC00083 HUMAN|HGNC=695|UniProtKB=P40617 P40617 ARL4A PTHR11711:SF139 ADP RIBOSYLATION FACTOR-RELATED ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 4A carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;ribonucleotide binding#GO:0032553;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;nucleotide binding#GO:0000166;ion binding#GO:0043167;nucleoside phosphate binding#GO:1901265;small molecule binding#GO:0036094;binding#GO:0005488;anion binding#GO:0043168;guanyl nucleotide binding#GO:0019001;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525 macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;vesicle-mediated transport#GO:0016192;intracellular transport#GO:0046907;intracellular protein transport#GO:0006886;transport#GO:0006810;establishment of localization#GO:0051234;cellular localization#GO:0051641;localization#GO:0051179;protein transport#GO:0015031;intracellular protein localization#GO:0008104 cell periphery#GO:0071944;membrane#GO:0016020;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 G-protein#PC00020 Huntington disease#P00029>ARF#P00786 HUMAN|HGNC=18991|UniProtKB=Q8IZF7 Q8IZF7 ADGRF2P PTHR45813:SF6 IG-LIKE DOMAIN-CONTAINING PROTEIN ADHESION G PROTEIN-COUPLED RECEPTOR F2P-RELATED transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;signaling receptor activity#GO:0038023 regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;cell communication#GO:0007154 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 G-protein coupled receptor#PC00021 HUMAN|HGNC=9982|UniProtKB=P22670 P22670 RFX1 PTHR12619:SF23 RFX TRANSCRIPTION FACTOR FAMILY MHC CLASS II REGULATORY FACTOR RFX1 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677 regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;nucleus#GO:0005634;intracellular organelle#GO:0043229 winged helix/forkhead transcription factor#PC00246 HUMAN|HGNC=17341|UniProtKB=Q96Q11 Q96Q11 TRNT1 PTHR46173:SF1 CCA TRNA NUCLEOTIDYLTRANSFERASE 1, MITOCHONDRIAL CCA TRNA NUCLEOTIDYLTRANSFERASE 1, MITOCHONDRIAL tRNA binding#GO:0000049;RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;RNA biosynthetic process#GO:0032774;nucleic acid biosynthetic process#GO:0141187;mitochondrial RNA metabolic process#GO:0000959;RNA metabolic process#GO:0016070;mitochondrial gene expression#GO:0140053;mitochondrial RNA processing#GO:0000963;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;gene expression#GO:0010467;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;RNA processing#GO:0006396;tRNA 3'-end processing#GO:0042780;mitochondrial RNA 3'-end processing#GO:0000965;metabolic process#GO:0008152;tRNA metabolic process#GO:0006399;nucleobase-containing compound biosynthetic process#GO:0034654;tRNA processing#GO:0008033;macromolecule metabolic process#GO:0043170;RNA 3'-end processing#GO:0031123 cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031;RNA processing factor#PC00147 HUMAN|HGNC=19652|UniProtKB=Q7RTT6 Q7RTT6 SSX6P PTHR14112:SF27 SYNOVIAL SARCOMA, X MEMBER PROTEIN SSX6-RELATED organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HUMAN|HGNC=12000|UniProtKB=Q13625 Q13625 TP53BP2 PTHR24131:SF8 APOPTOSIS-STIMULATING OF P53 PROTEIN APOPTOSIS-STIMULATING OF P53 PROTEIN 2 binding#GO:0005488;protein binding#GO:0005515 programmed cell death#GO:0012501;regulation of biological process#GO:0050789;cell death#GO:0008219;cellular response to stimulus#GO:0051716;apoptotic process#GO:0006915;response to stimulus#GO:0050896;intrinsic apoptotic signaling pathway by p53 class mediator#GO:0072332;regulation of cellular process#GO:0050794;signaling#GO:0023052;signal transduction by p53 class mediator#GO:0072331;cell communication#GO:0007154;intrinsic apoptotic signaling pathway#GO:0097193;intracellular signal transduction#GO:0035556;signal transduction#GO:0007165;cellular process#GO:0009987;biological regulation#GO:0065007;apoptotic signaling pathway#GO:0097190 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;adherens junction#GO:0005912;membrane-bounded organelle#GO:0043227;cell junction#GO:0030054;nucleus#GO:0005634;cell-cell junction#GO:0005911;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;perinuclear region of cytoplasm#GO:0048471;cellular anatomical structure#GO:0110165;organelle#GO:0043226 protein-binding activity modulator#PC00095 HUMAN|HGNC=15027|UniProtKB=Q8NGZ6 Q8NGZ6 OR6F1 PTHR26454:SF12 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 6F1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=17722|UniProtKB=Q7Z698 Q7Z698 SPRED2 PTHR11202:SF11 SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN 2 binding#GO:0005488;kinase binding#GO:0019900;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;protein binding#GO:0005515 regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648;negative regulation of intracellular signal transduction#GO:1902532;negative regulation of MAPK cascade#GO:0043409;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;regulation of response to stimulus#GO:0048583;regulation of MAPK cascade#GO:0043408;negative regulation of cellular process#GO:0048523;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of response to stimulus#GO:0048585;negative regulation of ERK1 and ERK2 cascade#GO:0070373;regulation of ERK1 and ERK2 cascade#GO:0070372 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=4165|UniProtKB=P54826 P54826 GAS1 PTHR16840:SF3 GROWTH ARREST-SPECIFIC PROTEIN 1 GROWTH ARREST-SPECIFIC PROTEIN 1 regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;regulation of transport#GO:0051049;biological regulation#GO:0065007;regulation of localization#GO:0032879;regulation of cellular process#GO:0050794 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 HUMAN|HGNC=14600|UniProtKB=O76081 O76081 RGS20 PTHR10845:SF277 REGULATOR OF G PROTEIN SIGNALING REGULATOR OF G PROTEIN SIGNALING 20 molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234;enzyme activator activity#GO:0008047 regulation of biological process#GO:0050789;negative regulation of G protein-coupled receptor signaling pathway#GO:0045744;negative regulation of biological process#GO:0048519;regulation of cell communication#GO:0010646;negative regulation of signal transduction#GO:0009968;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;negative regulation of response to stimulus#GO:0048585;regulation of cellular process#GO:0050794;regulation of signaling#GO:0023051;regulation of G protein-coupled receptor signaling pathway#GO:0008277;regulation of response to stimulus#GO:0048583;negative regulation of cellular process#GO:0048523;negative regulation of signaling#GO:0023057;negative regulation of cell communication#GO:0010648 cell periphery#GO:0071944;cytoplasmic side of membrane#GO:0098562;membrane#GO:0016020;cytoplasmic side of plasma membrane#GO:0009898;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552 GTPase-activating protein#PC00257 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>RGS#P00704;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>RGS#P00731 HUMAN|HGNC=31793|UniProtKB=Q8TCE6 Q8TCE6 DENND10 PTHR28544:SF1 PROTEIN FAM45A-RELATED DENN DOMAIN-CONTAINING PROTEIN 10-RELATED nucleoside-triphosphatase regulator activity#GO:0060589;GTPase regulator activity#GO:0030695;molecular function regulator activity#GO:0098772;small GTPase binding#GO:0031267;enzyme regulator activity#GO:0030234;protein binding#GO:0005515;guanyl-nucleotide exchange factor activity#GO:0005085;binding#GO:0005488;enzyme binding#GO:0019899 localization#GO:0051179;establishment of localization#GO:0051234;intracellular protein localization#GO:0008104;regulation of localization#GO:0032879;regulation of transport#GO:0051049;protein transport#GO:0015031;transport#GO:0006810;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;macromolecule localization#GO:0033036;regulation of vesicle-mediated transport#GO:0060627;regulation of biological process#GO:0050789;establishment of protein localization#GO:0045184 endosome#GO:0005768;intracellular organelle#GO:0043229;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;vesicle#GO:0031982;intracellular vesicle#GO:0097708;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;late endosome#GO:0005770;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=6917|UniProtKB=Q9UBB5 Q9UBB5 MBD2 PTHR12396:SF5 METHYL-CPG BINDING PROTEIN, MBD METHYL-CPG-BINDING DOMAIN PROTEIN 2 cellular component organization or biogenesis#GO:0071840;DNA methylation-dependent constitutive heterochromatin formation#GO:0006346;negative regulation of gene expression, epigenetic#GO:0045814;constitutive heterochromatin formation#GO:0140719;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;cellular component assembly#GO:0022607;heterochromatin organization#GO:0070828;cellular component biogenesis#GO:0044085;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular process#GO:0009987;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of transcription by RNA polymerase II#GO:0006357;negative regulation of metabolic process#GO:0009892;chromatin remodeling#GO:0006338;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;cellular component organization#GO:0016043;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of cellular process#GO:0048523;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;chromatin organization#GO:0006325;negative regulation of biosynthetic process#GO:0009890;regulation of primary metabolic process#GO:0080090;epigenetic regulation of gene expression#GO:0040029;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;regulation of DNA-templated transcription#GO:0006355;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;heterochromatin formation#GO:0031507 transcription regulator complex#GO:0005667;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;chromatin#GO:0000785;nucleus#GO:0005634;histone deacetylase complex#GO:0000118;membrane-enclosed lumen#GO:0031974;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;catalytic complex#GO:1902494;ATPase complex#GO:1904949;intracellular organelle lumen#GO:0070013;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;SWI/SNF superfamily-type complex#GO:0070603;chromosome#GO:0005694;organelle lumen#GO:0043233 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=17985|UniProtKB=Q8WZ75 Q8WZ75 ROBO4 PTHR10075:SF146 BASIGIN RELATED ROUNDABOUT HOMOLOG 4 cell adhesion molecule#PC00069 HUMAN|HGNC=29857|UniProtKB=Q9ULX6 Q9ULX6 AKAP8L PTHR12190:SF4 A-KINASE ANCHOR PROTEIN AKAP 8 A-KINASE ANCHOR PROTEIN 8-LIKE protein kinase A regulatory subunit binding#GO:0034237;protein kinase A binding#GO:0051018;binding#GO:0005488;protein binding#GO:0005515 mitotic cell cycle#GO:0000278;cell cycle#GO:0007049;cellular component organization#GO:0016043;sister chromatid segregation#GO:0000819;nuclear chromosome segregation#GO:0098813;mitotic nuclear division#GO:0140014;cell cycle process#GO:0022402;organelle fission#GO:0048285;mitotic chromosome condensation#GO:0007076;chromosome condensation#GO:0030261;nuclear division#GO:0000280;mitotic sister chromatid segregation#GO:0000070;organelle organization#GO:0006996;cellular process#GO:0009987;cellular component organization or biogenesis#GO:0071840;mitotic cell cycle process#GO:1903047;chromosome organization#GO:0051276;chromosome segregation#GO:0007059 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;nucleus#GO:0005634;organelle lumen#GO:0043233;membrane-enclosed lumen#GO:0031974;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013 scaffold/adaptor protein#PC00226 HUMAN|HGNC=4283|UniProtKB=P08034 P08034 GJB1 PTHR11984:SF20 CONNEXIN GAP JUNCTION BETA-1 PROTEIN channel activity#GO:0015267;wide pore channel activity#GO:0022829;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;passive transmembrane transporter activity#GO:0022803 regulation of biological process#GO:0050789;cellular process#GO:0009987;cell communication#GO:0007154;biological regulation#GO:0065007;signaling#GO:0023052;cell-cell signaling#GO:0007267 cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;cell-cell junction#GO:0005911;membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;anchoring junction#GO:0070161;cell junction#GO:0030054 cell junction protein#PC00070;gap junction#PC00105 HUMAN|HGNC=29917|UniProtKB=Q8TC05 Q8TC05 SAXO6 PTHR32078:SF1 NUCLEAR PROTEIN MDM1 STABILIZER OF AXONEMAL MICROTUBULES 6 protein binding#GO:0005515;microtubule binding#GO:0008017;binding#GO:0005488;cytoskeletal protein binding#GO:0008092;tubulin binding#GO:0015631 regulation of cellular process#GO:0050794;regulation of cellular component organization#GO:0051128;visual system development#GO:0150063;regulation of cell cycle#GO:0051726;regulation of biological process#GO:0050789;anatomical structure development#GO:0048856;eye development#GO:0001654;system development#GO:0048731;animal gross anatomical part developmental process#GO:0160108;regulation of microtubule-based process#GO:0032886;camera-type eye development#GO:0043010;multicellular organismal process#GO:0032501;retina development in camera-type eye#GO:0060041;regulation of cell cycle process#GO:0010564;biological regulation#GO:0065007;sensory system development#GO:0048880;animal organ development#GO:0048513;multicellular organism development#GO:0007275;sensory organ development#GO:0007423;developmental process#GO:0032502 centriole#GO:0005814;centriolar satellite#GO:0034451;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;microtubule cytoskeleton#GO:0015630;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;microtubule organizing center#GO:0005815;centrosome#GO:0005813 HUMAN|HGNC=16700|UniProtKB=Q8WW38 Q8WW38 ZFPM2 PTHR12958:SF5 FRIEND OF GATA2-RELATED ZINC FINGER PROTEIN ZFPM2 DNA-binding transcription factor binding#GO:0140297;RNA polymerase II-specific DNA-binding transcription factor binding#GO:0061629;protein binding#GO:0005515;transcription regulator activity#GO:0140110;binding#GO:0005488;transcription factor binding#GO:0008134;transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712 negative regulation of macromolecule biosynthetic process#GO:0010558;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of macromolecule metabolic process#GO:0010604;heart development#GO:0007507;positive regulation of transcription by RNA polymerase II#GO:0045944;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;multicellular organism development#GO:0007275;animal organ development#GO:0048513;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;circulatory system development#GO:0072359;cell differentiation#GO:0030154;negative regulation of metabolic process#GO:0009892;animal gross anatomical part developmental process#GO:0160108;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;negative regulation of DNA-templated transcription#GO:0045892;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;multicellular organismal process#GO:0032501;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA biosynthetic process#GO:2001141;negative regulation of biosynthetic process#GO:0009890;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;negative regulation of cellular process#GO:0048523;developmental process#GO:0032502;cellular developmental process#GO:0048869;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;positive regulation of biosynthetic process#GO:0009891;anatomical structure development#GO:0048856;regulation of DNA-templated transcription#GO:0006355;negative regulation of transcription by RNA polymerase II#GO:0000122;system development#GO:0048731;regulation of RNA metabolic process#GO:0051252 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;transcription cofactor#PC00217 HUMAN|HGNC=9820|UniProtKB=O43502 O43502 RAD51C PTHR46239:SF1 DNA REPAIR PROTEIN RAD51 HOMOLOG 3 RAD51C DNA REPAIR PROTEIN RAD51 HOMOLOG 3 DNA nuclease activity#GO:0004536;hydrolase activity, acting on ester bonds#GO:0016788;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;endonuclease activity#GO:0004519;catalytic activity, acting on DNA#GO:0140097;binding#GO:0005488;nucleic acid binding#GO:0003676;four-way junction DNA binding#GO:0000400;nuclease activity#GO:0004518;DNA binding#GO:0003677;DNA endonuclease activity#GO:0004520;hydrolase activity#GO:0016787 cellular component organization or biogenesis#GO:0071840;protein-DNA complex organization#GO:0071824;double-strand break repair#GO:0006302;protein-containing complex organization#GO:0043933;DNA metabolic process#GO:0006259;metabolic process#GO:0008152;meiotic cell cycle#GO:0051321;DNA recombination#GO:0006310;cellular component assembly#GO:0022607;protein-DNA complex assembly#GO:0065004;response to stress#GO:0006950;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;nuclear division#GO:0000280;reciprocal meiotic recombination#GO:0007131;cellular response to stress#GO:0033554;response to stimulus#GO:0050896;cellular component organization#GO:0016043;meiotic cell cycle process#GO:1903046;meiosis I#GO:0007127;double-strand break repair via homologous recombination#GO:0000724;cell cycle process#GO:0022402;protein-containing complex assembly#GO:0065003;meiotic nuclear division#GO:0140013;macromolecule metabolic process#GO:0043170;DNA repair#GO:0006281;DNA damage response#GO:0006974;nucleobase-containing compound metabolic process#GO:0006139;organelle fission#GO:0048285;recombinational repair#GO:0000725;meiosis I cell cycle process#GO:0061982;sexual reproduction#GO:0019953;reproductive process#GO:0022414;homologous recombination#GO:0035825;nucleic acid metabolic process#GO:0090304;primary metabolic process#GO:0044238;cell cycle#GO:0007049;cellular response to stimulus#GO:0051716;reciprocal homologous recombination#GO:0140527 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;replication fork#GO:0005657;chromosome#GO:0005694 DNA metabolism protein#PC00009 HUMAN|HGNC=14312|UniProtKB=Q9P021 Q9P021 CRIPT PTHR11805:SF2 CYSTEINE-RICH PDZ-BINDING PROTEIN CYSTEINE-RICH PDZ-BINDING PROTEIN protein binding#GO:0005515;tubulin binding#GO:0015631;cytoskeletal protein binding#GO:0008092;binding#GO:0005488;microtubule binding#GO:0008017 cytoplasmic microtubule organization#GO:0031122;cytoskeleton organization#GO:0007010;cellular component organization#GO:0016043;organelle organization#GO:0006996;cellular process#GO:0009987;microtubule cytoskeleton organization#GO:0000226;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;supramolecular fiber organization#GO:0097435 dendritic tree#GO:0097447;neuron projection#GO:0043005;dendrite#GO:0030425;plasma membrane bounded cell projection#GO:0120025;somatodendritic compartment#GO:0036477;cell projection#GO:0042995;cellular anatomical structure#GO:0110165 HUMAN|HGNC=12924|UniProtKB=P17017 P17017 ZNF14 PTHR24379:SF111 KRAB AND ZINC FINGER DOMAIN-CONTAINING ZINC FINGER PROTEIN 14 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677 regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 gene-specific transcriptional regulator#PC00264;DNA-binding transcription factor#PC00218;zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=5877|UniProtKB=P01703 P01703 IGLV1-40 PTHR23267:SF535 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN LAMBDA VARIABLE 1-40-RELATED immune system process#GO:0002376;immune response#GO:0006955;response to stimulus#GO:0050896 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=34447|UniProtKB=P47929 P47929 LGALS7 PTHR11346:SF107 GALECTIN GALECTIN-7 binding#GO:0005488;carbohydrate binding#GO:0030246 extracellular matrix protein#PC00102 HUMAN|HGNC=18869|UniProtKB=Q86UU5 Q86UU5 GGN PTHR47742:SF1 GAMETOGENETIN GAMETOGENETIN ubiquitin protein ligase binding#GO:0031625;protein binding#GO:0005515;enzyme binding#GO:0019899;binding#GO:0005488;ubiquitin-like protein ligase binding#GO:0044389 HUMAN|HGNC=15534|UniProtKB=Q969V4 Q969V4 TEKT1 PTHR19960:SF25 TEKTIN TEKTIN-1 cilium movement involved in cell motility#GO:0060294;cellular component biogenesis#GO:0044085;organelle organization#GO:0006996;cellular process#GO:0009987;cell projection assembly#GO:0030031;cellular component assembly#GO:0022607;plasma membrane bounded cell projection organization#GO:0120036;plasma membrane bounded cell projection assembly#GO:0120031;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;cellular component organization#GO:0016043;cilium assembly#GO:0060271;microtubule-based movement#GO:0007018;cell motility#GO:0048870;cell projection organization#GO:0030030;organelle assembly#GO:0070925;cilium movement#GO:0003341;cilium or flagellum-dependent cell motility#GO:0001539;cilium-dependent cell motility#GO:0060285;cilium organization#GO:0044782 intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;microtubule cytoskeleton#GO:0015630;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856 non-motor microtubule binding protein#PC00166;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=4562|UniProtKB=Q13588 Q13588 GRAP PTHR46037:SF2 PROTEIN ENHANCER OF SEVENLESS 2B GRB2-RELATED ADAPTER PROTEIN protein binding#GO:0005515;growth factor receptor binding#GO:0070851;signaling receptor binding#GO:0005102;binding#GO:0005488 cell communication#GO:0007154;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583;regulation of MAPK cascade#GO:0043408;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;regulation of cell communication#GO:0010646;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;signaling#GO:0023052;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789 intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;COP9 signalosome#GO:0008180;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;nucleoplasm#GO:0005654;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;intracellular membrane-bounded organelle#GO:0043231;nuclear protein-containing complex#GO:0140513;membrane#GO:0016020;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;cell periphery#GO:0071944;protein-containing complex#GO:0032991;plasma membrane#GO:0005886;cytoplasm#GO:0005737 Angiogenesis#P00005>Grb2#P00252;EGF receptor signaling pathway#P00018>Grb2#P00550;B cell activation#P00010>Grb2#P00372;FGF signaling pathway#P00021>Grb2#P00631;Inflammation mediated by chemokine and cytokine signaling pathway#P00031>Grb#P00848;Angiogenesis#P00005>Grb2#P00234;Integrin signalling pathway#P00034>Grb2#P00910;PDGF signaling pathway#P00047>Grb2#P01148 HUMAN|HGNC=53923|UniProtKB=P0DPK3 P0DPK3 NOTCH2NLB PTHR24044:SF507 NOTCH LIGAND FAMILY MEMBER NOTCH HOMOLOG 2 N-TERMINAL-LIKE PROTEIN B signaling receptor binding#GO:0005102;binding#GO:0005488;protein binding#GO:0005515 intercellular signal molecule#PC00207 HUMAN|HGNC=32063|UniProtKB=P0DPA2 P0DPA2 VSIG8 PTHR45166:SF1 V-SET AND IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN 8 V-SET AND IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN 8 immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=2727|UniProtKB=Q99489 Q99489 DDO PTHR11530:SF31 D-AMINO ACID OXIDASE D-ASPARTATE OXIDASE catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491 primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;carboxylic acid catabolic process#GO:0046395;cellular process#GO:0009987;small molecule metabolic process#GO:0044281;catabolic process#GO:0009056;small molecule catabolic process#GO:0044282;amino acid metabolic process#GO:0006520;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152 membrane-bounded organelle#GO:0043227;peroxisomal matrix#GO:0005782;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;microbody#GO:0042579;peroxisome#GO:0005777;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233 oxidase#PC00175 HUMAN|HGNC=28159|UniProtKB=Q3B7J2 Q3B7J2 GFOD2 PTHR43818:SF8 BCDNA.GH03377 GLUCOSE-FRUCTOSE OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 2 cellular process#GO:0009987;extracellular structure organization#GO:0043062;cellular component organization#GO:0016043;external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198;cellular component organization or biogenesis#GO:0071840 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312 dehydrogenase#PC00092 HUMAN|HGNC=19010|UniProtKB=Q8IZF4 Q8IZF4 ADGRG5 PTHR12011:SF326 ADHESION G-PROTEIN COUPLED RECEPTOR ADHESION G PROTEIN-COUPLED RECEPTOR G5 transmembrane signaling receptor activity#GO:0004888;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 G protein-coupled receptor signaling pathway#GO:0007186;cell communication#GO:0007154;regulation of biological process#GO:0050789;signal transduction#GO:0007165;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=29920|UniProtKB=Q7Z7K6 Q7Z7K6 CENPV PTHR28620:SF4 CENTROMERE PROTEIN V CENTROMERE PROTEIN V heterochromatin formation#GO:0031507;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of cell division#GO:0051302;negative regulation of macromolecule metabolic process#GO:0010605;positive regulation of cellular process#GO:0048522;epigenetic regulation of gene expression#GO:0040029;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;chromatin organization#GO:0006325;regulation of chromosome organization#GO:0033044;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of organelle organization#GO:0033043;positive regulation of cell cycle process#GO:0090068;regulation of biological process#GO:0050789;cellular component organization#GO:0016043;negative regulation of gene expression#GO:0010629;negative regulation of biological process#GO:0048519;chromatin remodeling#GO:0006338;regulation of cell cycle#GO:0051726;negative regulation of metabolic process#GO:0009892;regulation of cellular component organization#GO:0051128;regulation of cytokinesis#GO:0032465;cellular process#GO:0009987;positive regulation of biological process#GO:0048518;negative regulation of macromolecule biosynthetic process#GO:0010558;cellular component biogenesis#GO:0044085;positive regulation of cell cycle#GO:0045787;heterochromatin organization#GO:0070828;regulation of cell cycle process#GO:0010564;cellular component assembly#GO:0022607;constitutive heterochromatin formation#GO:0140719;negative regulation of gene expression, epigenetic#GO:0045814;cellular component organization or biogenesis#GO:0071840 nucleus#GO:0005634;microtubule cytoskeleton#GO:0015630;condensed chromosome, centromeric region#GO:0000779;intracellular membraneless organelle#GO:0043232;supramolecular complex#GO:0099080;spindle#GO:0005819;condensed chromosome#GO:0000793;chromosome, centromeric region#GO:0000775;cytoskeleton#GO:0005856;membraneless organelle#GO:0043228;kinetochore#GO:0000776;chromosome#GO:0005694;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;spindle midzone#GO:0051233;chromosomal region#GO:0098687 HUMAN|HGNC=10350|UniProtKB=P62891 P62891 RPL39 PTHR19970:SF25 RIBOSOMAL PROTEIN L39E LARGE RIBOSOMAL SUBUNIT PROTEIN EL39 structural constituent of ribosome#GO:0003735;structural molecule activity#GO:0005198 gene expression#GO:0010467;protein biosynthetic process#GO:0160307;cytoplasmic translation#GO:0002181;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;translation#GO:0006412 cytosol#GO:0005829;cytosolic large ribosomal subunit#GO:0022625;cytosolic ribosome#GO:0022626;ribosome#GO:0005840;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;cytoplasm#GO:0005737;ribonucleoprotein complex#GO:1990904;large ribosomal subunit#GO:0015934;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 ribosomal protein#PC00202 HUMAN|HGNC=16510|UniProtKB=Q5XUX0 Q5XUX0 FBXO31 PTHR10706:SF161 F-BOX FAMILY PROTEIN F-BOX ONLY PROTEIN 31 molecular adaptor activity#GO:0060090;protein-macromolecule adaptor activity#GO:0030674;enzyme-substrate adaptor activity#GO:0140767;ubiquitin-like ligase-substrate adaptor activity#GO:1990756 protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;SCF-dependent proteasomal ubiquitin-dependent protein catabolic process#GO:0031146;macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941 catalytic complex#GO:1902494;transferase complex#GO:1990234;ubiquitin ligase complex#GO:0000151;protein-containing complex#GO:0032991;intracellular protein-containing complex#GO:0140535;SCF ubiquitin ligase complex#GO:0019005;cullin-RING ubiquitin ligase complex#GO:0031461 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=12337|UniProtKB=Q9UL62 Q9UL62 TRPC5 PTHR10117:SF76 TRANSIENT RECEPTOR POTENTIAL CHANNEL SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 5 alcohol binding#GO:0043178;metal ion transmembrane transporter activity#GO:0046873;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;transporter activity#GO:0005215;calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;binding#GO:0005488;monoatomic cation channel activity#GO:0005261;calcium channel activity#GO:0005262;transmembrane transporter activity#GO:0022857;passive transmembrane transporter activity#GO:0022803;channel activity#GO:0015267;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094 monoatomic cation homeostasis#GO:0055080;chemical homeostasis#GO:0048878;intracellular monoatomic cation homeostasis#GO:0030003;transport#GO:0006810;calcium ion transport#GO:0006816;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;establishment of localization#GO:0051234;cellular process#GO:0009987;monoatomic ion homeostasis#GO:0050801;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;inorganic ion homeostasis#GO:0098771;calcium ion homeostasis#GO:0055074;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;monoatomic cation transport#GO:0006812;localization#GO:0051179;regulation of cytosolic calcium ion concentration#GO:0051480;calcium ion transmembrane transport#GO:0070588;intracellular monoatomic ion homeostasis#GO:0006873;metal ion transport#GO:0030001;homeostatic process#GO:0042592 protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;monoatomic ion channel complex#GO:0034702;plasma membrane#GO:0005886;membrane protein complex#GO:0098796;membrane#GO:0016020;cell periphery#GO:0071944;transmembrane transporter complex#GO:1902495;transporter complex#GO:1990351;cation channel complex#GO:0034703 ion channel#PC00133 Alzheimer disease-presenilin pathway#P00004>Capacitative calcium channels#P00124 HUMAN|HGNC=29025|UniProtKB=O15090 O15090 ZNF536 PTHR45925:SF2 ZINC FINGER PROTEIN ZINC FINGER PROTEIN 536 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;transcription regulatory region nucleic acid binding#GO:0001067;DNA binding#GO:0003677;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 gene-specific transcriptional regulator#PC00264;C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=3164|UniProtKB=O60869 O60869 EDF1 PTHR10245:SF15 ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 MULTIPROTEIN BRIDGING FACTOR 1 ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;transcription coactivator activity#GO:0003713 regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of biological process#GO:0050789;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 HUMAN|HGNC=28166|UniProtKB=Q5VUJ9 Q5VUJ9 DRC8 PTHR46763:SF1 DYNEIN REGULATORY COMPLEX PROTEIN 8 DYNEIN REGULATORY COMPLEX PROTEIN 8 plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;sperm flagellum#GO:0036126;organelle#GO:0043226;motile cilium#GO:0031514;sperm principal piece#GO:0097228;membrane-bounded organelle#GO:0043227;cilium#GO:0005929;9+2 motile cilium#GO:0097729 microtubule or microtubule-binding cytoskeletal protein#PC00157;cytoskeletal protein#PC00085 HUMAN|HGNC=1053|UniProtKB=Q9UBW5 Q9UBW5 BIN2 PTHR46514:SF1 AMPHIPHYSIN BRIDGING INTEGRATOR 2 lipid binding#GO:0008289;phospholipid binding#GO:0005543;binding#GO:0005488 localization#GO:0051179;plasma membrane organization#GO:0007009;cell projection organization#GO:0030030;endocytosis#GO:0006897;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;protein-containing complex organization#GO:0043933;phagocytosis, engulfment#GO:0006911;cellular component organization or biogenesis#GO:0071840;import into cell#GO:0098657;establishment of localization#GO:0051234;membrane invagination#GO:0010324;transport#GO:0006810;plasma membrane bounded cell projection assembly#GO:0120031;phagocytosis#GO:0006909;endomembrane system organization#GO:0010256;membrane organization#GO:0061024;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;cell projection assembly#GO:0030031;cellular process#GO:0009987;cellular component biogenesis#GO:0044085 intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;plasma membrane bounded cell projection#GO:0120025;intracellular membraneless organelle#GO:0043232;plasma membrane#GO:0005886;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cell periphery#GO:0071944;actin-based cell projection#GO:0098858;membrane#GO:0016020;actin cytoskeleton#GO:0015629 HUMAN|HGNC=19093|UniProtKB=Q9NYI0 Q9NYI0 PSD3 PTHR10663:SF337 GUANYL-NUCLEOTIDE EXCHANGE FACTOR PH AND SEC7 DOMAIN-CONTAINING PROTEIN 3 cell periphery#GO:0071944;membrane#GO:0016020;cell leading edge#GO:0031252;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;plasma membrane region#GO:0098590;leading edge membrane#GO:0031256;ruffle membrane#GO:0032587;ruffle#GO:0001726;cell projection membrane#GO:0031253 guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=29362|UniProtKB=Q9C0D7 Q9C0D7 ZC3H12C PTHR12876:SF36 N4BP1-RELATED RIBONUCLEASE ZC3H12C-RELATED binding#GO:0005488;nucleic acid binding#GO:0003676;mRNA binding#GO:0003729;RNA binding#GO:0003723;nuclease activity#GO:0004518;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;catalytic activity, acting on RNA#GO:0140098;RNA endonuclease activity#GO:0004521;RNA nuclease activity#GO:0004540;endonuclease activity#GO:0004519 regulation of RNA metabolic process#GO:0051252;regulation of RNA stability#GO:0043487;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of mRNA catabolic process#GO:0061014;regulation of gene expression#GO:0010468;regulation of catabolic process#GO:0009894;positive regulation of catabolic process#GO:0009896;regulation of biosynthetic process#GO:0009889;post-transcriptional regulation of gene expression#GO:0010608;negative regulation of cellular process#GO:0048523;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of biological quality#GO:0065008;positive regulation of metabolic process#GO:0009893;negative regulation of metabolic process#GO:0009892;regulation of mRNA stability#GO:0043488;regulation of biological process#GO:0050789;negative regulation of biological process#GO:0048519;regulation of mRNA catabolic process#GO:0061013;negative regulation of gene expression#GO:0010629;regulation of mRNA metabolic process#GO:1903311;mRNA destabilization#GO:0061157;positive regulation of mRNA metabolic process#GO:1903313;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of biological process#GO:0048518;negative regulation of macromolecule biosynthetic process#GO:0010558;RNA destabilization#GO:0050779 nucleus#GO:0005634;intracellular membraneless organelle#GO:0043232;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;supramolecular complex#GO:0099080;organelle#GO:0043226;ribonucleoprotein granule#GO:0035770;cytoplasmic ribonucleoprotein granule#GO:0036464;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;membraneless organelle#GO:0043228 endoribonuclease#PC00094 HUMAN|HGNC=34435|UniProtKB=Q2WGJ6 Q2WGJ6 KLHL38 PTHR24412:SF462 KELCH PROTEIN KELCH-LIKE PROTEIN 38 ubiquitin-like ligase-substrate adaptor activity#GO:1990756;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;enzyme-substrate adaptor activity#GO:0140767 macromolecule catabolic process#GO:0009057;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161;metabolic process#GO:0008152;modification-dependent macromolecule catabolic process#GO:0043632;protein catabolic process#GO:0030163;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;ubiquitin-dependent protein catabolic process#GO:0006511;primary metabolic process#GO:0044238;cellular process#GO:0009987;modification-dependent protein catabolic process#GO:0019941;catabolic process#GO:0009056;proteasomal protein catabolic process#GO:0010498 cytoplasm#GO:0005737;cullin-RING ubiquitin ligase complex#GO:0031461;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;ubiquitin ligase complex#GO:0000151;Cul3-RING ubiquitin ligase complex#GO:0031463 scaffold/adaptor protein#PC00226 HUMAN|HGNC=24156|UniProtKB=Q96BD5 Q96BD5 PHF21A PTHR24102:SF6 PHD FINGER PROTEIN PHD FINGER PROTEIN 21A chromatin binding#GO:0003682;binding#GO:0005488 nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;histone deacetylase complex#GO:0000118;membrane-enclosed lumen#GO:0031974;protein-containing complex#GO:0032991;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981 HUMAN|HGNC=18277|UniProtKB=P60059 P60059 SEC61G PTHR12309:SF5 SEC61 GAMMA SUBUNIT PROTEIN TRANSPORT PROTEIN SEC61 SUBUNIT GAMMA transmembrane protein transporter activity#GO:0008320;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857 post-translational protein targeting to membrane, translocation#GO:0031204;protein transport#GO:0015031;localization#GO:0051179;cellular localization#GO:0051641;transmembrane transport#GO:0055085;localization within membrane#GO:0051668;post-translational protein targeting to endoplasmic reticulum membrane#GO:0006620;protein targeting#GO:0006605;intracellular protein localization#GO:0008104;protein targeting to ER#GO:0045047;establishment of protein localization to organelle#GO:0072594;establishment of localization#GO:0051234;intracellular protein transmembrane transport#GO:0065002;protein transmembrane transport#GO:0071806;transport#GO:0006810;intracellular protein transport#GO:0006886;protein targeting to membrane#GO:0006612;intracellular transport#GO:0046907;establishment of protein localization to endoplasmic reticulum#GO:0072599;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;cellular process#GO:0009987;macromolecule localization#GO:0033036;establishment of protein localization to membrane#GO:0090150 intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;rough endoplasmic reticulum#GO:0005791;intracellular anatomical structure#GO:0005622;rough endoplasmic reticulum membrane#GO:0030867;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;membrane protein complex#GO:0098796;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;intracellular membrane-bounded organelle#GO:0043231;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum#GO:0005783;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588;endoplasmic reticulum protein-containing complex#GO:0140534;membrane#GO:0016020;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cytoplasm#GO:0005737 primary active transporter#PC00068 HUMAN|HGNC=12468|UniProtKB=P0CG48 P0CG48 UBC PTHR10666:SF530 UBIQUITIN POLYUBIQUITIN-C structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 catabolic process#GO:0009056;protein modification process#GO:0036211;primary metabolic process#GO:0044238;protein modification by small protein conjugation#GO:0032446;modification-dependent protein catabolic process#GO:0019941;protein metabolic process#GO:0019538;macromolecule modification#GO:0043412;protein modification by small protein conjugation or removal#GO:0070647;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;protein ubiquitination#GO:0016567;post-translational protein modification#GO:0043687;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057 ribosome#GO:0005840;nucleus#GO:0005634;cytosolic ribosome#GO:0022626;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;membraneless organelle#GO:0043228 HUMAN|HGNC=30164|UniProtKB=Q6FIF0 Q6FIF0 ZFAND6 PTHR10634:SF25 AN1-TYPE ZINC FINGER PROTEIN AN1-TYPE ZINC FINGER PROTEIN 6 binding#GO:0005488;modification-dependent protein binding#GO:0140030;polyubiquitin modification-dependent protein binding#GO:0031593;protein binding#GO:0005515 establishment of localization#GO:0051234;protein targeting#GO:0006605;localization#GO:0051179;establishment of protein localization to organelle#GO:0072594;establishment of protein localization#GO:0045184 HUMAN|HGNC=960|UniProtKB=Q9NRL2 Q9NRL2 BAZ1A PTHR46510:SF1 BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 1A BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 1A binding#GO:0005488;nucleic acid binding#GO:0003676;DNA binding#GO:0003677 regulation of chromatin organization#GO:1902275;regulation of RNA metabolic process#GO:0051252;regulation of DNA replication#GO:0006275;positive regulation of metabolic process#GO:0009893;regulation of DNA-templated transcription#GO:0006355;regulation of biological process#GO:0050789;regulation of DNA metabolic process#GO:0051052;positive regulation of DNA metabolic process#GO:0051054;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;positive regulation of DNA replication#GO:0045740;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604 ISWI-type complex#GO:0031010;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;ATPase complex#GO:1904949;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;chromosome#GO:0005694;SWI/SNF superfamily-type complex#GO:0070603;membraneless organelle#GO:0043228;nuclear protein-containing complex#GO:0140513;protein-containing complex#GO:0032991;nuclear chromosome#GO:0000228;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;chromatin#GO:0000785 HUMAN|HGNC=28992|UniProtKB=Q92628 Q92628 KIAA0232 PTHR17611:SF3 DNA SEGMENT, CHR 5, ERATO DOI 579, EXPRESSED KIAA0232 HOMOLOG HUMAN|HGNC=24087|UniProtKB=Q0VD83 Q0VD83 APOBR PTHR15964:SF0 APOLIPOPROTEIN B48 RECEPTOR APOLIPOPROTEIN B RECEPTOR cargo receptor activity#GO:0038024 glycerolipid metabolic process#GO:0046486;cellular process#GO:0009987;primary metabolic process#GO:0044238;neutral lipid metabolic process#GO:0006638;triglyceride metabolic process#GO:0006641;lipid metabolic process#GO:0006629;acylglycerol metabolic process#GO:0006639;metabolic process#GO:0008152 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 HUMAN|HGNC=8770|UniProtKB=Q13371 Q13371 PDCL PTHR46052:SF4 PHOSDUCIN-LIKE PROTEIN PHOSDUCIN-LIKE PROTEIN protein-containing complex organization#GO:0043933;cellular component assembly#GO:0022607;cellular component organization or biogenesis#GO:0071840;cellular process#GO:0009987;protein-containing complex assembly#GO:0065003;cellular component organization#GO:0016043;cellular component biogenesis#GO:0044085 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=6150|UniProtKB=P06756 P06756 ITGAV PTHR23220:SF4 INTEGRIN ALPHA INTEGRIN ALPHA-V molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 biological regulation#GO:0065007;tube development#GO:0035295;multicellular organismal process#GO:0032501;signal transduction#GO:0007165;cellular process#GO:0009987;cell-cell adhesion#GO:0098609;vasculature development#GO:0001944;anatomical structure formation involved in morphogenesis#GO:0048646;multicellular organism development#GO:0007275;developmental process#GO:0032502;cell surface receptor signaling pathway#GO:0007166;signaling#GO:0023052;circulatory system development#GO:0072359;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789;blood vessel development#GO:0001568;cellular response to stimulus#GO:0051716;tube morphogenesis#GO:0035239;integrin-mediated signaling pathway#GO:0007229;blood vessel morphogenesis#GO:0048514;system development#GO:0048731;cell-substrate adhesion#GO:0031589;cell communication#GO:0007154;angiogenesis#GO:0001525;anatomical structure development#GO:0048856;cell-matrix adhesion#GO:0007160;cell adhesion#GO:0007155;animal gross anatomical part developmental process#GO:0160108 membrane#GO:0016020;membrane protein complex#GO:0098796;plasma membrane protein complex#GO:0098797;cell periphery#GO:0071944;protein complex involved in cell adhesion#GO:0098636;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;plasma membrane#GO:0005886;signaling receptor complex#GO:0043235;integrin complex#GO:0008305 integrin#PC00126;cell adhesion molecule#PC00069 CCKR signaling map#P06959>ITGAV#G07293;CCKR signaling map#P06959>ITGAV#G06999;CCKR signaling map#P06959>ITGAV#P07133;Integrin signalling pathway#P00034>Integrin alpha#P00941 HUMAN|HGNC=30329|UniProtKB=P78345 P78345 RPP38 PTHR46948:SF1 RIBONUCLEASE P PROTEIN SUBUNIT P38 RIBONUCLEASE P PROTEIN SUBUNIT P38 endoribonuclease#PC00094 HUMAN|HGNC=15912|UniProtKB=Q9UNZ2 Q9UNZ2 NSFL1C PTHR23333:SF24 UBX DOMAIN CONTAINING PROTEIN NSFL1 COFACTOR P47 protein binding#GO:0005515;binding#GO:0005488;ubiquitin binding#GO:0043130 regulation of cell cycle#GO:0051726;establishment of organelle localization#GO:0051656;regulation of biological process#GO:0050789;positive regulation of cell cycle process#GO:0090068;cell cycle process#GO:0022402;cellular component organization#GO:0016043;cellular localization#GO:0051641;spindle localization#GO:0051653;protein catabolic process#GO:0030163;modification-dependent macromolecule catabolic process#GO:0043632;establishment or maintenance of cell polarity#GO:0007163;regulation of cell cycle process#GO:0010564;cytoskeleton organization#GO:0007010;positive regulation of cell cycle#GO:0045787;proteasomal protein catabolic process#GO:0010498;establishment of localization in cell#GO:0051649;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;organelle organization#GO:0006996;establishment of mitotic spindle localization#GO:0040001;establishment of spindle orientation#GO:0051294;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;mitotic cell cycle#GO:0000278;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;modification-dependent protein catabolic process#GO:0019941;establishment of cell polarity#GO:0030010;cell cycle#GO:0007049;microtubule cytoskeleton organization involved in mitosis#GO:1902850;primary metabolic process#GO:0044238;localization#GO:0051179;protein metabolic process#GO:0019538;microtubule cytoskeleton organization#GO:0000226;organelle localization#GO:0051640;biological regulation#GO:0065007;establishment of spindle localization#GO:0051293;positive regulation of cellular process#GO:0048522;mitotic cell cycle process#GO:1903047;ubiquitin-dependent protein catabolic process#GO:0006511;macromolecule metabolic process#GO:0043170;establishment of localization#GO:0051234;establishment of mitotic spindle orientation#GO:0000132;proteasome-mediated ubiquitin-dependent protein catabolic process#GO:0043161 nucleus#GO:0005634;cytosol#GO:0005829;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;ATPase complex#GO:1904949;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622 protein-binding activity modulator#PC00095 HUMAN|HGNC=28657|UniProtKB=Q9BSW2 Q9BSW2 CRACR2A PTHR47977:SF65 RAS-RELATED PROTEIN RAB EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 4B nucleoside phosphate binding#GO:1901265;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;guanyl nucleotide binding#GO:0019001;guanyl ribonucleotide binding#GO:0032561;GTP binding#GO:0005525;carbohydrate derivative binding#GO:0097367;purine nucleotide binding#GO:0017076;purine ribonucleoside triphosphate binding#GO:0035639;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;heterocyclic compound binding#GO:1901363;purine ribonucleotide binding#GO:0032555;GTPase activity#GO:0003924;ion binding#GO:0043167;small molecule binding#GO:0036094;anion binding#GO:0043168;hydrolase activity#GO:0016787;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111 establishment of localization#GO:0051234;vesicle-mediated transport#GO:0016192;localization#GO:0051179;cellular process#GO:0009987;transport#GO:0006810 small GTPase#PC00208 HUMAN|HGNC=3955|UniProtKB=P42685 P42685 FRK PTHR24418:SF468 TYROSINE-PROTEIN KINASE TYROSINE-PROTEIN KINASE FRK catalytic activity#GO:0003824;transferase activity#GO:0016740;protein tyrosine kinase activity#GO:0004713;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity, acting on a protein#GO:0140096;signaling receptor binding#GO:0005102;binding#GO:0005488;non-membrane spanning protein tyrosine kinase activity#GO:0004715;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein binding#GO:0005515;protein kinase activity#GO:0004672 cell surface receptor signaling pathway#GO:0007166;developmental process#GO:0032502;cell surface receptor protein tyrosine kinase signaling pathway#GO:0007169;cellular developmental process#GO:0048869;enzyme-linked receptor protein signaling pathway#GO:0007167;cell communication#GO:0007154;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;cell differentiation#GO:0030154;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 non-receptor tyrosine protein kinase#PC00168 B cell activation#P00010>Blk#P00390;Integrin signalling pathway#P00034>Src#P00940;Parkinson disease#P00049>Src kinase#P01230;Parkinson disease#P00049>Fyn kinase#P01235;Axon guidance mediated by semaphorins#P00007>Fyn#P00335;Cadherin signaling pathway#P00012>Fyn#P00464 HUMAN|HGNC=3711|UniProtKB=P62942 P62942 FKBP1A PTHR10516:SF301 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP1A-RELATED catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;peptidyl-prolyl cis-trans isomerase activity#GO:0003755;isomerase activity#GO:0016853;cis-trans isomerase activity#GO:0016859 regulation of muscle contraction#GO:0006937;regulation of muscle system process#GO:0090257;regulation of biological process#GO:0050789;response to stimulus#GO:0050896;protein folding#GO:0006457;signaling#GO:0023052;metabolic process#GO:0008152;regulation of release of sequestered calcium ion into cytosol#GO:0051279;regulation of transport#GO:0051049;regulation of localization#GO:0032879;regulation of monoatomic ion transmembrane transport#GO:0034765;cellular process#GO:0009987;signal transduction#GO:0007165;gene expression#GO:0010467;protein maturation#GO:0051604;intracellular signaling cassette#GO:0141124;regulation of multicellular organismal process#GO:0051239;protein metabolic process#GO:0019538;cell communication#GO:0007154;intracellular signal transduction#GO:0035556;regulation of transmembrane transport#GO:0034762;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;regulation of cellular process#GO:0050794;regulation of metal ion transport#GO:0010959;regulation of heart contraction#GO:0008016;regulation of system process#GO:0044057;regulation of monoatomic cation transmembrane transport#GO:1904062;macromolecule metabolic process#GO:0043170;calcium-mediated signaling#GO:0019722;macromolecule biosynthetic process#GO:0009059;regulation of monoatomic ion transport#GO:0043269;biosynthetic process#GO:0009058;regulation of calcium ion transport#GO:0051924;biological regulation#GO:0065007 intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;sarcoplasm#GO:0016528;intracellular anatomical structure#GO:0005622;organelle subcompartment#GO:0031984;membrane-bounded organelle#GO:0043227;sarcoplasmic reticulum#GO:0016529;membrane#GO:0016020;cytoplasm#GO:0005737;endomembrane system#GO:0012505;sarcoplasmic reticulum membrane#GO:0033017;endoplasmic reticulum#GO:0005783;endoplasmic reticulum membrane#GO:0005789;organelle membrane#GO:0031090;bounding membrane of organelle#GO:0098588 chaperone#PC00072 TGF-beta signaling pathway#P00052>FKBP12#P01288 HUMAN|HGNC=28209|UniProtKB=Q96LK0 Q96LK0 CEP19 PTHR31539:SF1 CENTROSOMAL PROTEIN OF 19K CEP19 CENTROSOMAL PROTEIN OF 19 KDA cellular component organization#GO:0016043;cilium assembly#GO:0060271;cell projection organization#GO:0030030;Golgi to plasma membrane transport#GO:0006893;localization within membrane#GO:0051668;organelle assembly#GO:0070925;post-Golgi vesicle-mediated transport#GO:0006892;trans-Golgi to periciliary membrane compartment transport#GO:0097712;cilium organization#GO:0044782;localization#GO:0051179;cellular localization#GO:0051641;microtubule cytoskeleton organization#GO:0000226;cell projection assembly#GO:0030031;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cytoskeleton organization#GO:0007010;plasma membrane bounded cell projection organization#GO:0120036;cellular component assembly#GO:0022607;vesicle-mediated transport#GO:0016192;transport#GO:0006810;Golgi vesicle transport#GO:0048193;plasma membrane bounded cell projection assembly#GO:0120031;vesicle-mediated transport to the plasma membrane#GO:0098876;microtubule-based process#GO:0007017;cellular component organization or biogenesis#GO:0071840;microtubule anchoring at microtubule organizing center#GO:0072393;microtubule anchoring#GO:0034453;establishment of localization#GO:0051234 ciliary basal body#GO:0036064;cytoskeleton#GO:0005856;spindle#GO:0005819;microtubule organizing center#GO:0005815;centrosome#GO:0005813;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;centriole#GO:0005814;intracellular membraneless organelle#GO:0043232;cilium#GO:0005929;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;spindle pole#GO:0000922;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=38689|UniProtKB=P0CJ88 P0CJ88 DUX4L5 PTHR46123:SF3 MIX-TYPE HOMEOBOX GENE 1-RELATED DOUBLE HOMEOBOX PROTEIN 1-RELATED sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular organelle#GO:0043229;nucleus#GO:0005634 homeodomain transcription factor#PC00119;helix-turn-helix transcription factor#PC00116 HUMAN|HGNC=10464|UniProtKB=Q15404 Q15404 RSU1 PTHR45752:SF156 LEUCINE-RICH REPEAT-CONTAINING RAS SUPPRESSOR PROTEIN 1 cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;intracellular signaling cassette#GO:0141124;small GTPase-mediated signal transduction#GO:0007264;signaling#GO:0023052;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;Ras protein signal transduction#GO:0007265;intracellular signal transduction#GO:0035556;cell communication#GO:0007154 scaffold/adaptor protein#PC00226 HUMAN|HGNC=12101|UniProtKB=A0A0B4J248 A0A0B4J248 TRAV1-1 PTHR19433:SF105 T-CELL RECEPTOR ALPHA CHAIN V REGION-RELATED T CELL RECEPTOR ALPHA VARIABLE 1-1-RELATED response to bacterium#GO:0009617;response to biotic stimulus#GO:0009607;response to stimulus#GO:0050896;response to external biotic stimulus#GO:0043207;response to external stimulus#GO:0009605;biological process involved in interspecies interaction between organisms#GO:0044419;response to other organism#GO:0051707 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=31042|UniProtKB=Q9C091 Q9C091 GREB1L PTHR15720:SF12 GREB1-RELATED GREB1-LIKE PROTEIN developmental process#GO:0032502;animal gross anatomical part developmental process#GO:0160108;system development#GO:0048731;morphogenesis of an epithelium#GO:0002009;tissue morphogenesis#GO:0048729;multicellular organism development#GO:0007275;anatomical structure development#GO:0048856;animal organ development#GO:0048513;anatomical structure morphogenesis#GO:0009653;renal system development#GO:0072001;kidney development#GO:0001822;epithelium development#GO:0060429;tissue development#GO:0009888;multicellular organismal process#GO:0032501 HUMAN|HGNC=21709|UniProtKB=Q9BVT8 Q9BVT8 TMUB1 PTHR14557:SF3 PROTEIN C7ORF21 TRANSMEMBRANE AND UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN 1 catabolic process#GO:0009056;response to stimulus#GO:0050896;primary metabolic process#GO:0044238;cellular response to stimulus#GO:0051716;protein metabolic process#GO:0019538;ERAD pathway#GO:0036503;response to endoplasmic reticulum stress#GO:0034976;cellular response to stress#GO:0033554;protein catabolic process#GO:0030163;response to chemical#GO:0042221;proteasomal protein catabolic process#GO:0010498;response to stress#GO:0006950;cellular process#GO:0009987;macromolecule metabolic process#GO:0043170;macromolecule catabolic process#GO:0009057;metabolic process#GO:0008152 HUMAN|HGNC=11331|UniProtKB=P30874 P30874 SSTR2 PTHR24229:SF6 NEUROPEPTIDES RECEPTOR SOMATOSTATIN RECEPTOR TYPE 2 peptide binding#GO:0042277;neuropeptide binding#GO:0042923;G protein-coupled peptide receptor activity#GO:0008528;transmembrane signaling receptor activity#GO:0004888;neuropeptide receptor activity#GO:0008188;binding#GO:0005488;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930 cellular response to steroid hormone stimulus#GO:0071383;signal transduction#GO:0007165;cellular response to oxygen-containing compound#GO:1901701;cellular process#GO:0009987;response to hormone#GO:0009725;biological regulation#GO:0065007;response to estradiol#GO:0032355;response to chemical#GO:0042221;response to lipid#GO:0033993;cellular response to lipid#GO:0071396;response to oxygen-containing compound#GO:1901700;cellular response to chemical stimulus#GO:0070887;G protein-coupled receptor signaling pathway#GO:0007186;response to steroid hormone#GO:0048545;cell communication#GO:0007154;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;response to endogenous stimulus#GO:0009719;neuropeptide signaling pathway#GO:0007218;signaling#GO:0023052;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;cellular response to hormone stimulus#GO:0032870;regulation of cellular process#GO:0050794 cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;plasma membrane#GO:0005886;cell projection#GO:0042995;membrane#GO:0016020;cell periphery#GO:0071944;neuron projection#GO:0043005 G-protein coupled receptor#PC00021 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GiPCR#P00711;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>GsPCR#P00720;Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway#P00027>GoPCR#P00725 HUMAN|HGNC=33543|UniProtKB=Q6IMI6 Q6IMI6 SULT1C3 PTHR11783:SF77 SULFOTRANSFERASE SULT SULFOTRANSFERASE 1C3 sulfotransferase activity#GO:0008146;transferase activity, transferring sulphur-containing groups#GO:0016782;transferase activity#GO:0016740;catalytic activity#GO:0003824 cellular process#GO:0009987;sulfur compound metabolic process#GO:0006790;metabolic process#GO:0008152 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 transferase#PC00220;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=13211|UniProtKB=P98194 P98194 ATP2C1 PTHR42861:SF2 CALCIUM-TRANSPORTING ATPASE CALCIUM-TRANSPORTING ATPASE TYPE 2C MEMBER 1 calcium ion transmembrane transporter activity#GO:0015085;monoatomic cation transmembrane transporter activity#GO:0008324;ATPase-coupled monoatomic cation transmembrane transporter activity#GO:0019829;ATP-dependent activity#GO:0140657;ATPase-coupled transmembrane transporter activity#GO:0042626;metal ion transmembrane transporter activity#GO:0046873;primary active transmembrane transporter activity#GO:0015399;active transmembrane transporter activity#GO:0022804;P-type ion transporter activity#GO:0015662;monoatomic ion transmembrane transporter activity#GO:0015075;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 monoatomic ion homeostasis#GO:0050801;cellular process#GO:0009987;monoatomic ion transmembrane transport#GO:0034220;monoatomic cation transmembrane transport#GO:0098655;transport#GO:0006810;chemical homeostasis#GO:0048878;monoatomic cation homeostasis#GO:0055080;intracellular monoatomic cation homeostasis#GO:0030003;establishment of localization#GO:0051234;calcium ion transport#GO:0006816;cellular homeostasis#GO:0019725;intracellular chemical homeostasis#GO:0055082;intracellular calcium ion homeostasis#GO:0006874;intracellular monoatomic ion homeostasis#GO:0006873;calcium ion transmembrane transport#GO:0070588;homeostatic process#GO:0042592;metal ion transport#GO:0030001;calcium ion homeostasis#GO:0055074;transition metal ion transport#GO:0000041;inorganic ion homeostasis#GO:0098771;transmembrane transport#GO:0055085;localization#GO:0051179;monoatomic cation transport#GO:0006812;monoatomic ion transport#GO:0006811 cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;endomembrane system#GO:0012505;cytoplasm#GO:0005737;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090;Golgi membrane#GO:0000139;Golgi apparatus#GO:0005794;endoplasmic reticulum#GO:0005783 primary active transporter#PC00068 HUMAN|HGNC=3259|UniProtKB=Q9NR50 Q9NR50 EIF2B3 PTHR45989:SF1 TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA TRANSLATION INITIATION FACTOR EIF2B SUBUNIT GAMMA enzyme regulator activity#GO:0030234;GTPase regulator activity#GO:0030695;nucleoside-triphosphatase regulator activity#GO:0060589;translation initiation factor activity#GO:0003743;molecular function regulator activity#GO:0098772;guanyl-nucleotide exchange factor activity#GO:0005085;translation factor activity#GO:0180051 translational initiation#GO:0006413;translation#GO:0006412;metabolic process#GO:0008152;cytoplasmic translational initiation#GO:0002183;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;biosynthetic process#GO:0009058;cytoplasmic translation#GO:0002181;gene expression#GO:0010467;protein biosynthetic process#GO:0160307 protein-containing complex#GO:0032991;guanyl-nucleotide exchange factor complex#GO:0032045;cellular anatomical structure#GO:0110165;intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 translational protein#PC00263;translation factor#PC00223;translation initiation factor#PC00224 HUMAN|HGNC=37295|UniProtKB=A4D2H0 A4D2H0 CTAGE15 PTHR23158:SF57 MELANOMA INHIBITORY ACTIVITY-RELATED CTAGE FAMILY MEMBER 15-RELATED vesicle-mediated transport#GO:0016192;macromolecule localization#GO:0033036;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;establishment of localization#GO:0051234;establishment of protein localization to extracellular region#GO:0035592;intracellular protein localization#GO:0008104;intracellular transport#GO:0046907;transport#GO:0006810;Golgi vesicle transport#GO:0048193;export from cell#GO:0140352;protein localization to extracellular region#GO:0071692;secretion#GO:0046903;cellular localization#GO:0051641;protein secretion#GO:0009306;localization#GO:0051179;protein transport#GO:0015031;endoplasmic reticulum to Golgi vesicle-mediated transport#GO:0006888;secretion by cell#GO:0032940 cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;membrane#GO:0016020;endomembrane system#GO:0012505;cytoplasm#GO:0005737;endoplasmic reticulum membrane#GO:0005789;endoplasmic reticulum exit site#GO:0070971;endoplasmic reticulum#GO:0005783;organelle membrane#GO:0031090 membrane traffic protein#PC00150 Nicotinic acetylcholine receptor signaling pathway#P00044>Myosin#P01097 HUMAN|HGNC=12866|UniProtKB=Q14590 Q14590 ZNF235 PTHR24377:SF954 IP01015P-RELATED ZINC FINGER PROTEIN 235 sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity#GO:0003700;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976 regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=12868|UniProtKB=O95159 O95159 ZFPL1 PTHR12981:SF0 ZINC FINGER PROTEIN-LIKE 1 ZINC FINGER PROTEIN-LIKE 1 Golgi apparatus#GO:0005794;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle#GO:0043226;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737 membrane traffic protein#PC00150 HUMAN|HGNC=29193|UniProtKB=Q9UPP2 Q9UPP2 IQSEC3 PTHR10663:SF318 GUANYL-NUCLEOTIDE EXCHANGE FACTOR IQ MOTIF AND SEC7 DOMAIN-CONTAINING PROTEIN 3 regulation of biological process#GO:0050789;regulation of vesicle-mediated transport#GO:0060627;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of receptor-mediated endocytosis#GO:0048259;regulation of cellular component organization#GO:0051128;regulation of endocytosis#GO:0030100;regulation of biological quality#GO:0065008;regulation of transport#GO:0051049;regulation of localization#GO:0032879 organelle#GO:0043226;asymmetric synapse#GO:0032279;synapse#GO:0045202;cellular anatomical structure#GO:0110165;postsynapse#GO:0098794;postsynaptic density membrane#GO:0098839;postsynaptic specialization membrane#GO:0099634;postsynaptic membrane#GO:0045211;postsynaptic density#GO:0014069;plasma membrane region#GO:0098590;postsynaptic specialization#GO:0099572;neuron to neuron synapse#GO:0098984;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944;cell junction#GO:0030054;synaptic membrane#GO:0097060 guanyl-nucleotide exchange factor#PC00113 HUMAN|HGNC=23237|UniProtKB=Q8WWP7 Q8WWP7 GIMAP1 PTHR10903:SF74 GTPASE, IMAP FAMILY MEMBER-RELATED GTPASE IMAP FAMILY MEMBER 1 hydrolase activity, acting on acid anhydrides#GO:0016817;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;GTPase activity#GO:0003924;ribonucleoside triphosphate phosphatase activity#GO:0017111;hydrolase activity#GO:0016787 endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229 small GTPase#PC00208 HUMAN|HGNC=6904|UniProtKB=P31153 P31153 MAT2A PTHR11964:SF73 S-ADENOSYLMETHIONINE SYNTHETASE S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2 catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring alkyl or aryl (other than methyl) groups#GO:0016765 cellular process#GO:0009987;metabolic process#GO:0008152;sulfur compound metabolic process#GO:0006790;biosynthetic process#GO:0009058 intracellular protein-containing complex#GO:0140535;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;transferase complex#GO:1990234;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;cytosol#GO:0005829 nucleotidyltransferase#PC00174;transferase#PC00220 S-adenosylmethionine biosynthesis#P02773>S-Adenosyl methionine synthetase#P03143 HUMAN|HGNC=12190|UniProtKB=A0A087WZ39 A0A087WZ39 TRBV15 PTHR23268:SF13 T-CELL RECEPTOR BETA CHAIN IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN cell communication#GO:0007154;cell surface receptor signaling pathway#GO:0007166;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=26397|UniProtKB=Q6UWN5 Q6UWN5 LYPD5 PTHR10624:SF9 UROKINASE PLASMINOGEN ACTIVATOR SURFACE RECEPTOR-RELATED LY6_PLAUR DOMAIN-CONTAINING PROTEIN 5 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 transmembrane signal receptor#PC00197 HUMAN|HGNC=10297|UniProtKB=P49247 P49247 RPIA PTHR11934:SF0 RIBOSE-5-PHOSPHATE ISOMERASE RIBOSE-5-PHOSPHATE ISOMERASE intramolecular oxidoreductase activity#GO:0016860;ribose-5-phosphate isomerase activity#GO:0004751;isomerase activity#GO:0016853;catalytic activity#GO:0003824;intramolecular oxidoreductase activity, interconverting aldoses and ketoses#GO:0016861 nucleobase-containing small molecule metabolic process#GO:0055086;monosaccharide metabolic process#GO:0005996;metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091;nucleobase-containing compound metabolic process#GO:0006139;NADP+ metabolic process#GO:0006739;organophosphate metabolic process#GO:0019637;cellular process#GO:0009987;aldehyde metabolic process#GO:0006081;nicotinamide nucleotide metabolic process#GO:0046496;carbohydrate derivative metabolic process#GO:1901135;nucleotide metabolic process#GO:0009117;pentose-phosphate shunt#GO:0006098;NADPH regeneration#GO:0006740;pyridine-containing compound metabolic process#GO:0072524;glyceraldehyde-3-phosphate metabolic process#GO:0019682;glucose 6-phosphate metabolic process#GO:0051156;small molecule metabolic process#GO:0044281;pentose-phosphate shunt, non-oxidative branch#GO:0009052;nucleoside phosphate metabolic process#GO:0006753;carbohydrate metabolic process#GO:0005975;primary metabolic process#GO:0044238;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 metabolite interconversion enzyme#PC00262;isomerase#PC00135 Pentose phosphate pathway#P02762>Ribulose 5-P Isomerase#P03071 HUMAN|HGNC=29914|UniProtKB=P57740 P57740 NUP107 PTHR13003:SF2 NUP107-RELATED NUCLEAR PORE COMPLEX PROTEIN NUP107 structural molecule activity#GO:0005198;structural constituent of nuclear pore#GO:0017056 cellular component organization#GO:0016043;protein import into nucleus#GO:0006606;protein transport#GO:0015031;mRNA export from nucleus#GO:0006406;cellular localization#GO:0051641;gene expression#GO:0010467;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;establishment of protein localization#GO:0045184;organelle organization#GO:0006996;cellular component organization or biogenesis#GO:0071840;intracellular protein transport#GO:0006886;metabolic process#GO:0008152;mRNA transport#GO:0051028;establishment of RNA localization#GO:0051236;RNA transport#GO:0050658;transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery#GO:0000972;RNA localization#GO:0006403;protein localization to organelle#GO:0033365;nucleobase-containing compound transport#GO:0015931;nuclear export#GO:0051168;nuclear transport#GO:0051169;nucleic acid transport#GO:0050657;localization#GO:0051179;nucleocytoplasmic transport#GO:0006913;biosynthetic process#GO:0009058;macromolecule biosynthetic process#GO:0009059;post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery#GO:0000973;protein localization to nucleus#GO:0034504;nitrogen compound transport#GO:0071705;import into nucleus#GO:0051170;macromolecule localization#GO:0033036;chromosome organization#GO:0051276;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;macromolecule metabolic process#GO:0043170;establishment of protein localization to organelle#GO:0072594;transport#GO:0006810;RNA export from nucleus#GO:0006405;intracellular transport#GO:0046907 organelle#GO:0043226;endomembrane system#GO:0012505;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nuclear envelope#GO:0005635;intracellular membrane-bounded organelle#GO:0043231;organelle envelope#GO:0031967;nuclear pore outer ring#GO:0031080;nucleus#GO:0005634;nuclear protein-containing complex#GO:0140513;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;nuclear pore#GO:0005643;intracellular organelle#GO:0043229 transporter#PC00227 HUMAN|HGNC=15102|UniProtKB=P0DN81 P0DN81 OR13C7 PTHR26453:SF635 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 13C7-RELATED molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 detection of chemical stimulus#GO:0009593;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;response to chemical#GO:0042221;response to stimulus#GO:0050896;multicellular organismal process#GO:0032501;sensory perception of smell#GO:0007608;sensory perception#GO:0007600;nervous system process#GO:0050877;sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;system process#GO:0003008 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197 HUMAN|HGNC=44452|UniProtKB=Q0WX57 Q0WX57 USP17L24 PTHR24006:SF651 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE INACTIVE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 17-LIKE PROTEIN 4-RELATED peptidase activity#GO:0008233;ubiquitin-like protein peptidase activity#GO:0019783;catalytic activity, acting on a protein#GO:0140096;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;cysteine-type deubiquitinase activity#GO:0004843;hydrolase activity#GO:0016787;deubiquitinase activity#GO:0101005 regulation of apoptotic process#GO:0042981;regulation of protein stability#GO:0031647;regulation of biological process#GO:0050789;regulation of programmed cell death#GO:0043067;regulation of biological quality#GO:0065008;biological regulation#GO:0065007;regulation of cellular process#GO:0050794 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;cytosol#GO:0005829 cysteine protease#PC00081;protease#PC00190 HUMAN|HGNC=8178|UniProtKB=P58182 P58182 OR12D2 PTHR26451:SF52 G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN OLFACTORY RECEPTOR 12D2 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;binding#GO:0005488;olfactory receptor activity#GO:0004984;transmembrane signaling receptor activity#GO:0004888 system process#GO:0003008;nervous system process#GO:0050877;sensory perception#GO:0007600;detection of chemical stimulus involved in sensory perception#GO:0050907;sensory perception of chemical stimulus#GO:0007606;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;response to stimulus#GO:0050896;response to chemical#GO:0042221;detection of chemical stimulus#GO:0009593;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606 cellular anatomical structure#GO:0110165;membrane#GO:0016020 G-protein coupled receptor#PC00021 HUMAN|HGNC=6412|UniProtKB=P04264 P04264 KRT1 PTHR45616:SF33 GATA-TYPE DOMAIN-CONTAINING PROTEIN KERATIN, TYPE II CYTOSKELETAL 1 structural molecule activity#GO:0005198 cell differentiation#GO:0030154;intermediate filament cytoskeleton organization#GO:0045104;cellular component organization#GO:0016043;supramolecular fiber organization#GO:0097435;anatomical structure development#GO:0048856;intermediate filament organization#GO:0045109;intermediate filament-based process#GO:0045103;animal gross anatomical part developmental process#GO:0160108;keratinocyte differentiation#GO:0030216;cytoskeleton organization#GO:0007010;skin development#GO:0043588;epithelium development#GO:0060429;multicellular organismal process#GO:0032501;epidermal cell differentiation#GO:0009913;tissue development#GO:0009888;epithelial cell differentiation#GO:0030855;cellular process#GO:0009987;organelle organization#GO:0006996;cellular component organization or biogenesis#GO:0071840;cellular developmental process#GO:0048869;animal organ development#GO:0048513;developmental process#GO:0032502;epidermis development#GO:0008544 cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;polymeric cytoskeletal fiber#GO:0099513;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;intermediate filament#GO:0005882;supramolecular polymer#GO:0099081;cellular anatomical structure#GO:0110165;organelle#GO:0043226;supramolecular complex#GO:0099080;intracellular membraneless organelle#GO:0043232 HUMAN|HGNC=24170|UniProtKB=Q8TDN6 Q8TDN6 BRIX1 PTHR13634:SF0 RIBOSOME BIOGENESIS PROTEIN BRIX RIBOSOME BIOGENESIS PROTEIN BRX1 HOMOLOG RNA binding#GO:0003723;nucleic acid binding#GO:0003676;binding#GO:0005488 protein-RNA complex organization#GO:0071826;cellular component organization or biogenesis#GO:0071840;protein-containing complex organization#GO:0043933;ribosomal large subunit assembly#GO:0000027;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;cellular process#GO:0009987;cellular component assembly#GO:0022607;ribosome biogenesis#GO:0042254;organelle assembly#GO:0070925;ribosomal large subunit biogenesis#GO:0042273;ribosome assembly#GO:0042255;protein-RNA complex assembly#GO:0022618;membraneless organelle assembly#GO:0140694;cellular component organization#GO:0016043;protein-containing complex assembly#GO:0065003;ribonucleoprotein complex biogenesis#GO:0022613 cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular membraneless organelle#GO:0043232;membrane-enclosed lumen#GO:0031974;organelle lumen#GO:0043233;nucleus#GO:0005634;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular organelle#GO:0043229 RNA metabolism protein#PC00031 HUMAN|HGNC=1755|UniProtKB=O75309 O75309 CDH16 PTHR24028:SF1 CADHERIN-87A CADHERIN-16 cell adhesion#GO:0007155;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 cadherin#PC00057;cell adhesion molecule#PC00069 Wnt signaling pathway#P00057>Cadherin#P01440;Cadherin signaling pathway#P00012>Cadherin#P00471 HUMAN|HGNC=4524|UniProtKB=Q8TCW9 Q8TCW9 PROKR1 PTHR24241:SF137 NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR PROKINETICIN RECEPTOR 1 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930;transmembrane signaling receptor activity#GO:0004888 circadian rhythm#GO:0007623;cell communication#GO:0007154;rhythmic process#GO:0048511;G protein-coupled receptor signaling pathway#GO:0007186;cellular response to chemical stimulus#GO:0070887;signaling#GO:0023052;regulation of cellular process#GO:0050794;cellular response to hormone stimulus#GO:0032870;cellular response to endogenous stimulus#GO:0071495;response to stimulus#GO:0050896;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;biological regulation#GO:0065007;response to chemical#GO:0042221;cellular process#GO:0009987;signal transduction#GO:0007165;response to hormone#GO:0009725 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 HUMAN|HGNC=12005|UniProtKB=P55327 P55327 TPD52 PTHR19307:SF12 TUMOR PROTEIN D52 TUMOR PROTEIN D52 cell development#GO:0048468;cell differentiation#GO:0030154;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;mononuclear cell differentiation#GO:1903131;leukocyte activation#GO:0045321;positive regulation of cell population proliferation#GO:0008284;leukocyte differentiation#GO:0002521;regulation of cell population proliferation#GO:0042127;anatomical structure development#GO:0048856;lymphocyte differentiation#GO:0030098;cell activation#GO:0001775;immune system process#GO:0002376;biological regulation#GO:0065007;hemopoiesis#GO:0030097;lymphocyte activation#GO:0046649;multicellular organismal process#GO:0032501;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;B cell activation#GO:0042113;cellular developmental process#GO:0048869;developmental process#GO:0032502 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 HUMAN|HGNC=29127|UniProtKB=O94915 O94915 FRYL PTHR12295:SF9 FURRY-RELATED PROTEIN FURRY HOMOLOG-LIKE plasma membrane bounded cell projection organization#GO:0120036;nervous system development#GO:0007399;multicellular organismal process#GO:0032501;cellular process#GO:0009987;neuron projection development#GO:0031175;neurogenesis#GO:0022008;cellular component organization or biogenesis#GO:0071840;multicellular organism development#GO:0007275;cellular developmental process#GO:0048869;neuron differentiation#GO:0030182;developmental process#GO:0032502;cell development#GO:0048468;cell differentiation#GO:0030154;cell projection organization#GO:0030030;cell morphogenesis#GO:0000902;anatomical structure morphogenesis#GO:0009653;cellular component organization#GO:0016043;system development#GO:0048731;neuron development#GO:0048666;anatomical structure development#GO:0048856;generation of neurons#GO:0048699;establishment or maintenance of cell polarity#GO:0007163;animal gross anatomical part developmental process#GO:0160108 cellular anatomical structure#GO:0110165;cell division site#GO:0032153;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 scaffold/adaptor protein#PC00226 HUMAN|HGNC=21905|UniProtKB=Q9NXC5 Q9NXC5 MIOS PTHR16453:SF9 WD40 DOMAIN-CONTAINING PROTEIN MIO FAMILY MEMBER GATOR2 COMPLEX PROTEIN MIOS cellular response to stress#GO:0033554;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;positive regulation of TOR signaling#GO:0032008;positive regulation of signaling#GO:0023056;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;positive regulation of signal transduction#GO:0009967;response to starvation#GO:0042594;regulation of cell communication#GO:0010646;response to stimulus#GO:0050896;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;cellular response to nutrient levels#GO:0031669;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;cellular response to starvation#GO:0009267;regulation of TORC1 signaling#GO:1903432;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;regulation of TOR signaling#GO:0032006;response to nutrient levels#GO:0031667;response to stress#GO:0006950;positive regulation of TORC1 signaling#GO:1904263;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;positive regulation of response to stimulus#GO:0048584;cellular response to amino acid starvation#GO:0034198 cellular anatomical structure#GO:0110165;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737 HUMAN|HGNC=18507|UniProtKB=Q96PJ5 Q96PJ5 FCRL4 PTHR11481:SF64 IMMUNOGLOBULIN FC RECEPTOR FC RECEPTOR-LIKE PROTEIN 4 signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;transmembrane signaling receptor activity#GO:0004888 signal transduction#GO:0007165;immune response#GO:0006955;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;biological regulation#GO:0065007;signaling#GO:0023052;immune system process#GO:0002376;cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154 cell surface#GO:0009986;cellular anatomical structure#GO:0110165;side of membrane#GO:0098552;plasma membrane#GO:0005886;membrane#GO:0016020;external side of plasma membrane#GO:0009897;cell periphery#GO:0071944 immunoglobulin receptor superfamily#PC00124;defense/immunity protein#PC00090 HUMAN|HGNC=21574|UniProtKB=Q8N6K7 Q8N6K7 SAMD3 PTHR47302:SF1 STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 3 STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 3 HUMAN|HGNC=16493|UniProtKB=Q9ULJ6 Q9ULJ6 ZMIZ1 PTHR10782:SF7 ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN 1 catalytic activity#GO:0003824;transferase activity#GO:0016740;transcription coregulator activity#GO:0003712;catalytic activity, acting on a protein#GO:0140096;transcription coactivator activity#GO:0003713;aminoacyltransferase activity#GO:0016755;molecular function regulator activity#GO:0098772;acyltransferase activity#GO:0016746;transcription regulator activity#GO:0140110;SUMO ligase activity#GO:0061665;SUMO transferase activity#GO:0019789;ubiquitin-like protein transferase activity#GO:0019787;ubiquitin-like protein ligase activity#GO:0061659;molecular function inhibitor activity#GO:0140678 primary metabolic process#GO:0044238;protein modification process#GO:0036211;regulation of receptor signaling pathway via STAT#GO:1904892;regulation of cell communication#GO:0010646;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;regulation of RNA metabolic process#GO:0051252;protein metabolic process#GO:0019538;regulation of DNA-templated transcription#GO:0006355;macromolecule modification#GO:0043412;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of signal transduction#GO:0009966;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;post-translational protein modification#GO:0043687;regulation of nucleobase-containing compound metabolic process#GO:0019219;negative regulation of response to stimulus#GO:0048585;regulation of response to stimulus#GO:0048583;regulation of receptor signaling pathway via JAK-STAT#GO:0046425;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;regulation of biological process#GO:0050789;protein modification by small protein conjugation#GO:0032446;negative regulation of biological process#GO:0048519;regulation of transcription by RNA polymerase II#GO:0006357;regulation of signaling#GO:0023051;negative regulation of signaling#GO:0023057;protein modification by small protein conjugation or removal#GO:0070647;negative regulation of cell communication#GO:0010648;cellular process#GO:0009987;negative regulation of signal transduction#GO:0009968;metabolic process#GO:0008152;protein sumoylation#GO:0016925 intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;organelle lumen#GO:0043233;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;intracellular organelle lumen#GO:0070013;intracellular membraneless organelle#GO:0043232;chromatin#GO:0000785;nucleus#GO:0005634;membrane-enclosed lumen#GO:0031974;membraneless organelle#GO:0043228 ubiquitin-protein ligase#PC00234 HUMAN|HGNC=28942|UniProtKB=Q8N6L1 Q8N6L1 KRTCAP2 PTHR32001:SF1 KERATINOCYTE-ASSOCIATED PROTEIN 2 DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT KCP2 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;carbohydrate derivative biosynthetic process#GO:1901137;metabolic process#GO:0008152;glycoprotein metabolic process#GO:0009100;biosynthetic process#GO:0009058;glycoprotein biosynthetic process#GO:0009101;protein N-linked glycosylation#GO:0006487;primary metabolic process#GO:0044238;carbohydrate derivative metabolic process#GO:1901135;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059 HUMAN|HGNC=14847|UniProtKB=Q9H341 Q9H341 OR51M1 PTHR26450:SF44 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 51M1 molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023;transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=3537|UniProtKB=P25116 P25116 F2R PTHR24232:SF20 G-PROTEIN COUPLED RECEPTOR PROTEINASE-ACTIVATED RECEPTOR 1 transmembrane signaling receptor activity#GO:0004888;G protein-coupled peptide receptor activity#GO:0008528;signaling receptor activity#GO:0038023;peptide receptor activity#GO:0001653;G protein-coupled receptor activity#GO:0004930;molecular transducer activity#GO:0060089 regulation of response to stimulus#GO:0048583;regulation of response to stress#GO:0080134;biological regulation#GO:0065007;regulation of multicellular organismal process#GO:0051239;positive regulation of response to stimulus#GO:0048584;regulation of coagulation#GO:0050818;regulation of response to external stimulus#GO:0032101;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;regulation of hemostasis#GO:1900046;cellular process#GO:0009987;regulation of response to wounding#GO:1903034;regulation of biological quality#GO:0065008;cell communication#GO:0007154;phospholipase C-activating G protein-coupled receptor signaling pathway#GO:0007200;positive regulation of coagulation#GO:0050820;G protein-coupled receptor signaling pathway#GO:0007186;signaling#GO:0023052;regulation of wound healing#GO:0061041;regulation of blood coagulation#GO:0030193;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;regulation of body fluid levels#GO:0050878;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;positive regulation of multicellular organismal process#GO:0051240 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 Angiogenesis#P00005>PAR#P00192;Blood coagulation#P00011>PAR-1#P00404 HUMAN|HGNC=14044|UniProtKB=Q4U2R6 Q4U2R6 MRPL51 PTHR13409:SF0 MITOCHONDRIAL 39S RIBOSOMAL PROTEIN L51 LARGE RIBOSOMAL SUBUNIT PROTEIN ML51 structural molecule activity#GO:0005198;structural constituent of ribosome#GO:0003735 metabolic process#GO:0008152;translation#GO:0006412;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;primary metabolic process#GO:0044238;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein biosynthetic process#GO:0160307;gene expression#GO:0010467;biosynthetic process#GO:0009058 membraneless organelle#GO:0043228;mitochondrial large ribosomal subunit#GO:0005762;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;ribosomal subunit#GO:0044391;mitochondrial protein-containing complex#GO:0098798;protein-containing complex#GO:0032991;membrane-enclosed lumen#GO:0031974;intracellular anatomical structure#GO:0005622;mitochondrial ribosome#GO:0005761;organellar ribosome#GO:0000313;membrane-bounded organelle#GO:0043227;mitochondrial matrix#GO:0005759;intracellular organelle#GO:0043229;large ribosomal subunit#GO:0015934;intracellular organelle lumen#GO:0070013;ribonucleoprotein complex#GO:1990904;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;ribosome#GO:0005840;mitochondrion#GO:0005739;organelle lumen#GO:0043233 translational protein#PC00263;ribosomal protein#PC00202 HUMAN|HGNC=1246|UniProtKB=P00736 P00736 C1R PTHR24255:SF25 COMPLEMENT COMPONENT 1, S SUBCOMPONENT-RELATED COMPLEMENT C1R SUBCOMPONENT catalytic activity#GO:0003824;serine-type endopeptidase activity#GO:0004252;catalytic activity, acting on a protein#GO:0140096;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;serine-type peptidase activity#GO:0008236;hydrolase activity#GO:0016787;serine hydrolase activity#GO:0017171 macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538;metabolic process#GO:0008152;proteolysis#GO:0006508;protein maturation#GO:0051604;gene expression#GO:0010467;biosynthetic process#GO:0009058;primary metabolic process#GO:0044238;zymogen activation#GO:0031638;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;protein processing#GO:0016485 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 serine protease#PC00203 HUMAN|HGNC=18367|UniProtKB=Q9ULC6 Q9ULC6 PADI1 PTHR10837:SF11 PEPTIDYLARGININE DEIMINASE PROTEIN-ARGININE DEIMINASE TYPE-1 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity#GO:0016787;catalytic activity#GO:0003824 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;nucleus#GO:0005634 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=5933|UniProtKB=A0A0B4J1Y8 A0A0B4J1Y8 IGLV9-49 PTHR23267:SF206 IMMUNOGLOBULIN LIGHT CHAIN IMMUNOGLOBULIN LAMBDA VARIABLE 9-49 response to stimulus#GO:0050896;immune response#GO:0006955;immune system process#GO:0002376 protein-containing complex#GO:0032991 defense/immunity protein#PC00090;immunoglobulin#PC00123 HUMAN|HGNC=12880|UniProtKB=Q8IYN0 Q8IYN0 ZNF100 PTHR24384:SF201 FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED ZINC FINGER PROTEIN 100-RELATED transcription regulator activity#GO:0140110;transcription cis-regulatory region binding#GO:0000976;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;cis-regulatory region sequence-specific DNA binding#GO:0000987;sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837 regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of cellular process#GO:0050794;regulation of biological process#GO:0050789;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 DNA-binding transcription factor#PC00218 HUMAN|HGNC=22427|UniProtKB=A4D256 A4D256 CDC14C PTHR23339:SF117 TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE DUAL SPECIFICITY PROTEIN PHOSPHATASE CDC14C hydrolase activity#GO:0016787;protein serine/threonine phosphatase activity#GO:0004722;phosphoprotein phosphatase activity#GO:0004721;catalytic activity, acting on a protein#GO:0140096;phosphoric ester hydrolase activity#GO:0042578;catalytic activity#GO:0003824;hydrolase activity, acting on ester bonds#GO:0016788;phosphatase activity#GO:0016791 plasma membrane bounded cell projection assembly#GO:0120031;cellular component organization or biogenesis#GO:0071840;microtubule-based process#GO:0007017;organelle organization#GO:0006996;cellular component biogenesis#GO:0044085;positive regulation of biological process#GO:0048518;cell projection assembly#GO:0030031;positive regulation of cellular process#GO:0048522;cellular process#GO:0009987;regulation of mitotic cell cycle#GO:0007346;cellular component assembly#GO:0022607;cytoskeleton organization#GO:0007010;regulation of cell cycle process#GO:0010564;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;positive regulation of cell cycle#GO:0045787;organelle assembly#GO:0070925;regulation of cytokinesis#GO:0032465;regulation of cell division#GO:0051302;regulation of mitotic cell cycle phase transition#GO:1901990;microtubule cytoskeleton organization#GO:0000226;cilium organization#GO:0044782;regulation of cell cycle phase transition#GO:1901987;cilium assembly#GO:0060271;cellular component organization#GO:0016043;positive regulation of cell cycle process#GO:0090068;regulation of biological process#GO:0050789;cell projection organization#GO:0030030;regulation of cellular process#GO:0050794;regulation of cell cycle#GO:0051726 membraneless organelle#GO:0043228;microtubule organizing center#GO:0005815;spindle#GO:0005819;centrosome#GO:0005813;cytoskeleton#GO:0005856;intracellular membraneless organelle#GO:0043232;cytoplasm#GO:0005737;microtubule cytoskeleton#GO:0015630;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;nucleolus#GO:0005730;intracellular organelle#GO:0043229;organelle#GO:0043226;cellular anatomical structure#GO:0110165;nuclear lumen#GO:0031981;mitotic spindle#GO:0072686;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233 protein modifying enzyme#PC00260;protein phosphatase#PC00195 HUMAN|HGNC=30909|UniProtKB=Q6UXR4 Q6UXR4 SERPINA13P PTHR11461:SF377 SERINE PROTEASE INHIBITOR, SERPIN SERPIN A13-RELATED enzyme inhibitor activity#GO:0004857;molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866;peptidase regulator activity#GO:0061134;endopeptidase regulator activity#GO:0061135;peptidase inhibitor activity#GO:0030414;serine-type endopeptidase inhibitor activity#GO:0004867;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 protease inhibitor#PC00191 HUMAN|HGNC=794|UniProtKB=P31939 P31939 ATIC PTHR11692:SF0 BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN ATIC catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring one-carbon groups#GO:0016741;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines#GO:0016814 ribose phosphate biosynthetic process#GO:0046390;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;nucleobase-containing compound biosynthetic process#GO:0034654;purine ribonucleotide metabolic process#GO:0009150;metabolic process#GO:0008152;carbohydrate derivative biosynthetic process#GO:1901137;purine nucleoside monophosphate metabolic process#GO:0009126;nucleobase-containing small molecule metabolic process#GO:0055086;phosphorus metabolic process#GO:0006793;purine-containing compound metabolic process#GO:0072521;purine nucleotide metabolic process#GO:0006163;small molecule metabolic process#GO:0044281;purine ribonucleoside monophosphate metabolic process#GO:0009167;ribonucleotide metabolic process#GO:0009259;nucleoside monophosphate biosynthetic process#GO:0009124;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide biosynthetic process#GO:0009165;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;carbohydrate derivative metabolic process#GO:1901135;nucleobase-containing compound metabolic process#GO:0006139;biosynthetic process#GO:0009058;nucleoside phosphate biosynthetic process#GO:1901293;primary metabolic process#GO:0044238;IMP metabolic process#GO:0046040;nucleoside phosphate metabolic process#GO:0006753;nucleoside monophosphate metabolic process#GO:0009123;organophosphate biosynthetic process#GO:0090407;IMP biosynthetic process#GO:0006188 cytosol#GO:0005829;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 De novo purine biosynthesis#P02738>AICAR transformylase#P02900;De novo purine biosynthesis#P02738>IMP cyclohydrolase#P02894 HUMAN|HGNC=43735|UniProtKB=P0DPK2 P0DPK2 H3Y1 PTHR11426:SF263 HISTONE H3 HISTONE H3.X-RELATED mitotic cell cycle#GO:0000278;mitotic nuclear division#GO:0140014;cell cycle process#GO:0022402;protein-containing complex assembly#GO:0065003;mitotic metaphase chromosome alignment#GO:0007080;cellular component organization#GO:0016043;sister chromatid segregation#GO:0000819;membraneless organelle assembly#GO:0140694;nuclear chromosome segregation#GO:0098813;cell cycle#GO:0007049;organelle fission#GO:0048285;kinetochore organization#GO:0051383;localization#GO:0051179;kinetochore assembly#GO:0051382;organelle localization#GO:0051640;nuclear division#GO:0000280;organelle assembly#GO:0070925;chromosome localization#GO:0050000;cellular component assembly#GO:0022607;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;mitotic sister chromatid segregation#GO:0000070;organelle organization#GO:0006996;chromosome organization#GO:0051276;protein-containing complex organization#GO:0043933;mitotic cell cycle process#GO:1903047;cellular component organization or biogenesis#GO:0071840;chromosome segregation#GO:0007059;metaphase chromosome alignment#GO:0051310 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=23312|UniProtKB=Q7Z6W1 Q7Z6W1 TMCO2 PTHR38496:SF1 TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 2 TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 2 HUMAN|HGNC=31331|UniProtKB=Q30KQ1 Q30KQ1 DEFB133 PTHR20515:SF17 BETA-DEFENSIN BETA-DEFENSIN 133 molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;G protein-coupled receptor binding#GO:0001664;chemokine receptor binding#GO:0042379;protein binding#GO:0005515;molecular function activator activity#GO:0140677;signaling receptor binding#GO:0005102;binding#GO:0005488;cytokine receptor binding#GO:0005126 response to chemical#GO:0042221;taxis#GO:0042330;cell migration#GO:0016477;response to other organism#GO:0051707;response to biotic stimulus#GO:0009607;response to stress#GO:0006950;cellular process#GO:0009987;response to external stimulus#GO:0009605;defense response#GO:0006952;response to stimulus#GO:0050896;cell motility#GO:0048870;biological process involved in interspecies interaction between organisms#GO:0044419;response to external biotic stimulus#GO:0043207;locomotion#GO:0040011;cellular response to stimulus#GO:0051716;cell chemotaxis#GO:0060326;response to bacterium#GO:0009617;cellular response to chemical stimulus#GO:0070887;chemotaxis#GO:0006935;defense response to bacterium#GO:0042742 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 defense/immunity protein#PC00090;antimicrobial response protein#PC00051 HUMAN|HGNC=16960|UniProtKB=P52954 P52954 LBX1 PTHR24336:SF9 TRANSCRIPTION FACTOR LBX TRANSCRIPTION FACTOR LBX1 DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;transcription regulator activity#GO:0140110;DNA binding#GO:0003677;double-stranded DNA binding#GO:0003690;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565 regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227 homeodomain transcription factor#PC00119 HUMAN|Ensembl=ENSG00000283864.2|UniProtKB=A0AAG2TJA1 A0AAG2TJA1 PTHR35683:SF7 YALI0C04136P APPLE DOMAIN-CONTAINING PROTEIN HUMAN|HGNC=11242|UniProtKB=Q01892 Q01892 SPIB PTHR11849:SF174 ETS TRANSCRIPTION FACTOR SPI-B DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110 regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;regulation of biological process#GO:0050789;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869;regulation of gene expression#GO:0010468;developmental process#GO:0032502;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;cellular process#GO:0009987 intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226;nucleus#GO:0005634;intracellular organelle#GO:0043229 DNA-binding transcription factor#PC00218;winged helix/forkhead transcription factor#PC00246 HUMAN|HGNC=7749|UniProtKB=Q9HC98 Q9HC98 NEK6 PTHR43289:SF13 MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED SERINE_THREONINE-PROTEIN KINASE NEK6 protein kinase activity#GO:0004672;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein serine/threonine kinase activity#GO:0004674;catalytic activity, acting on a protein#GO:0140096;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity#GO:0003824;transferase activity#GO:0016740 regulation of mitotic metaphase/anaphase transition#GO:0030071;regulation of cell cycle process#GO:0010564;biological regulation#GO:0065007;regulation of mitotic cell cycle#GO:0007346;cellular process#GO:0009987;regulation of chromosome organization#GO:0033044;regulation of chromosome segregation#GO:0051983;chromosome segregation#GO:0007059;regulation of cellular component organization#GO:0051128;regulation of metaphase/anaphase transition of cell cycle#GO:1902099;regulation of cellular process#GO:0050794;regulation of cell cycle#GO:0051726;regulation of sister chromatid segregation#GO:0033045;cell cycle#GO:0007049;regulation of cell cycle phase transition#GO:1901987;regulation of biological process#GO:0050789;cell cycle process#GO:0022402;regulation of organelle organization#GO:0033043;regulation of mitotic cell cycle phase transition#GO:1901990 cytosol#GO:0005829;intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=4088|UniProtKB=Q99928 Q99928 GABRG3 PTHR18945:SF195 NEUROTRANSMITTER GATED ION CHANNEL GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT GAMMA-3 passive transmembrane transporter activity#GO:0022803;ligand-gated channel activity#GO:0022834;neurotransmitter receptor activity#GO:0030594;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215;extracellular ligand-gated monoatomic ion channel activity#GO:0005230;monoatomic ion channel activity#GO:0005216;monoatomic ion transmembrane transporter activity#GO:0015075;transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential#GO:1904315;signaling receptor activity#GO:0038023;gated channel activity#GO:0022836;ligand-gated monoatomic ion channel activity#GO:0015276;transmembrane signaling receptor activity#GO:0004888;molecular transducer activity#GO:0060089;channel activity#GO:0015267 cell-cell signaling#GO:0007267;biological regulation#GO:0065007;monoatomic ion transmembrane transport#GO:0034220;multicellular organismal process#GO:0032501;establishment of localization#GO:0051234;developmental process#GO:0032502;transport#GO:0006810;anterograde trans-synaptic signaling#GO:0098916;cell junction organization#GO:0034330;monoatomic anion transport#GO:0006820;chemical synaptic transmission#GO:0007268;system development#GO:0048731;cell communication#GO:0007154;chloride transmembrane transport#GO:1902476;localization#GO:0051179;anatomical structure development#GO:0048856;synapse organization#GO:0050808;trans-synaptic signaling#GO:0099537;nervous system development#GO:0007399;cellular component assembly#GO:0022607;monoatomic anion transmembrane transport#GO:0098656;cellular process#GO:0009987;cellular component biogenesis#GO:0044085;synaptic signaling#GO:0099536;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;chloride transport#GO:0006821;signaling#GO:0023052;synapse assembly#GO:0007416;regulation of biological process#GO:0050789;cell junction assembly#GO:0034329;cellular component organization#GO:0016043;inorganic anion transport#GO:0015698;monoatomic ion transport#GO:0006811;transmembrane transport#GO:0055085;animal gross anatomical part developmental process#GO:0160108 cell junction#GO:0030054;neuron projection membrane#GO:0032589;signaling receptor complex#GO:0043235;protein-containing complex#GO:0032991;plasma membrane region#GO:0098590;plasma membrane#GO:0005886;somatodendritic compartment#GO:0036477;membrane#GO:0016020;cell leading edge#GO:0031252;cell periphery#GO:0071944;neuron projection#GO:0043005;cell projection membrane#GO:0031253;dendrite#GO:0030425;dendritic tree#GO:0097447;leading edge membrane#GO:0031256;synapse#GO:0045202;cellular anatomical structure#GO:0110165;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995;postsynapse#GO:0098794 ligand-gated ion channel#PC00141 HUMAN|HGNC=26001|UniProtKB=Q6ZP29 Q6ZP29 SLC66A1 PTHR16201:SF36 SEVEN TRANSMEMBRANE PROTEIN 1-RELATED LYSOSOMAL AMINO ACID TRANSPORTER 1 HOMOLOG basic amino acid transmembrane transporter activity#GO:0015174;aromatic amino acid transmembrane transporter activity#GO:0015173;L-amino acid transmembrane transporter activity#GO:0015179;amino acid transmembrane transporter activity#GO:0015171;transporter activity#GO:0005215;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943 organic acid transport#GO:0015849;chemical homeostasis#GO:0048878;amino acid transport#GO:0006865;carboxylic acid transport#GO:0046942;transport#GO:0006810;intracellular chemical homeostasis#GO:0055082;cellular homeostasis#GO:0019725;vacuolar transmembrane transport#GO:0034486;establishment of localization#GO:0051234;cellular process#GO:0009987;L-amino acid transport#GO:0015807;nitrogen compound transport#GO:0071705;localization#GO:0051179;amino acid transmembrane transport#GO:0003333;transmembrane transport#GO:0055085;L-alpha-amino acid transmembrane transport#GO:1902475;homeostatic process#GO:0042592;carboxylic acid transmembrane transport#GO:1905039 organelle#GO:0043226;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;lytic vacuole membrane#GO:0098852;lysosome#GO:0005764;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;vacuole#GO:0005773;cytoplasm#GO:0005737;membrane#GO:0016020;lysosomal membrane#GO:0005765;lytic vacuole#GO:0000323;vacuolar membrane#GO:0005774;bounding membrane of organelle#GO:0098588;organelle membrane#GO:0031090 HUMAN|HGNC=7963|UniProtKB=Q14995 Q14995 NR1D2 PTHR24082:SF112 NUCLEAR HORMONE RECEPTOR NUCLEAR RECEPTOR SUBFAMILY 1 GROUP D MEMBER 2 sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;nucleic acid binding#GO:0003676;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;molecular transducer activity#GO:0060089;cis-regulatory region sequence-specific DNA binding#GO:0000987;nuclear receptor activity#GO:0004879;DNA binding#GO:0003677;sequence-specific DNA binding#GO:0043565;signaling receptor activity#GO:0038023;transcription regulator activity#GO:0140110;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;transcription regulatory region nucleic acid binding#GO:0001067 regulation of biological process#GO:0050789;response to endogenous stimulus#GO:0009719;negative regulation of biological process#GO:0048519;negative regulation of metabolic process#GO:0009892;signaling#GO:0023052;response to stimulus#GO:0050896;cellular response to endogenous stimulus#GO:0071495;regulation of transcription by RNA polymerase II#GO:0006357;cell differentiation#GO:0030154;cellular response to hormone stimulus#GO:0032870;cellular response to chemical stimulus#GO:0070887;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;positive regulation of metabolic process#GO:0009893;positive regulation of macromolecule biosynthetic process#GO:0010557;hormone-mediated signaling pathway#GO:0009755;negative regulation of DNA-templated transcription#GO:0045892;positive regulation of biological process#GO:0048518;signal transduction#GO:0007165;cellular process#GO:0009987;negative regulation of macromolecule biosynthetic process#GO:0010558;response to hormone#GO:0009725;response to chemical#GO:0042221;positive regulation of macromolecule metabolic process#GO:0010604;negative regulation of RNA biosynthetic process#GO:1902679;negative regulation of RNA metabolic process#GO:0051253;positive regulation of transcription by RNA polymerase II#GO:0045944;cellular response to stimulus#GO:0051716;positive regulation of RNA metabolic process#GO:0051254;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;cell communication#GO:0007154;positive regulation of biosynthetic process#GO:0009891;regulation of DNA-templated transcription#GO:0006355;positive regulation of cellular process#GO:0048522;negative regulation of macromolecule metabolic process#GO:0010605;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of biosynthetic process#GO:0009890;biological regulation#GO:0065007;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;developmental process#GO:0032502;negative regulation of cellular process#GO:0048523;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;cellular developmental process#GO:0048869 organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;nucleus#GO:0005634 C4 zinc finger nuclear receptor#PC00169 HUMAN|HGNC=10681|UniProtKB=P21912 P21912 SDHB PTHR11921:SF47 SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT, MITOCHONDRIAL cellular respiration#GO:0045333;energy derivation by oxidation of organic compounds#GO:0015980;aerobic respiration#GO:0009060;metabolic process#GO:0008152;generation of precursor metabolites and energy#GO:0006091;electron transport chain#GO:0022900;cellular process#GO:0009987;respiratory electron transport chain#GO:0022904 intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrial envelope#GO:0005740;mitochondrial membrane#GO:0031966;mitochondrion#GO:0005739;membrane#GO:0016020;organelle envelope#GO:0031967 oxidoreductase#PC00176;dehydrogenase#PC00092;metabolite interconversion enzyme#PC00262 HUMAN|HGNC=362|UniProtKB=P54819 P54819 AK2 PTHR23359:SF227 NUCLEOTIDE KINASE ADENYLATE KINASE 2, MITOCHONDRIAL kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;catalytic activity#GO:0003824;nucleobase-containing compound kinase activity#GO:0019205;transferase activity#GO:0016740;phosphotransferase activity, phosphate group as acceptor#GO:0016776 nucleotide metabolic process#GO:0009117;purine ribonucleotide biosynthetic process#GO:0009152;nucleotide biosynthetic process#GO:0009165;purine nucleotide biosynthetic process#GO:0006164;purine-containing compound biosynthetic process#GO:0072522;ribonucleotide metabolic process#GO:0009259;purine nucleoside diphosphate metabolic process#GO:0009135;small molecule metabolic process#GO:0044281;phosphorus metabolic process#GO:0006793;purine nucleotide metabolic process#GO:0006163;purine-containing compound metabolic process#GO:0072521;ribonucleoside diphosphate metabolic process#GO:0009185;carbohydrate derivative biosynthetic process#GO:1901137;nucleobase-containing small molecule metabolic process#GO:0055086;metabolic process#GO:0008152;purine ribonucleotide metabolic process#GO:0009150;nucleobase-containing compound biosynthetic process#GO:0034654;ribose phosphate biosynthetic process#GO:0046390;ribose phosphate metabolic process#GO:0019693;cellular process#GO:0009987;organophosphate biosynthetic process#GO:0090407;nucleoside diphosphate metabolic process#GO:0009132;nucleoside phosphate metabolic process#GO:0006753;primary metabolic process#GO:0044238;nucleoside phosphate biosynthetic process#GO:1901293;ADP metabolic process#GO:0046031;purine ribonucleoside diphosphate metabolic process#GO:0009179;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;organophosphate metabolic process#GO:0019637;ribonucleotide biosynthetic process#GO:0009260;carbohydrate derivative metabolic process#GO:1901135 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226;mitochondrion#GO:0005739 nucleotide kinase#PC00172;kinase#PC00137 De novo purine biosynthesis#P02738>Adenylate kinase#P02896 HUMAN|HGNC=6146|UniProtKB=Q13349 Q13349 ITGAD PTHR23220:SF132 INTEGRIN ALPHA INTEGRIN ALPHA-D molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cell communication#GO:0007154;cell-substrate adhesion#GO:0031589;cell surface receptor signaling pathway#GO:0007166;cell adhesion#GO:0007155;cell-matrix adhesion#GO:0007160;biological regulation#GO:0065007;signaling#GO:0023052;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cellular process#GO:0009987;cellular response to stimulus#GO:0051716;signal transduction#GO:0007165;regulation of biological process#GO:0050789;integrin-mediated signaling pathway#GO:0007229;cell-cell adhesion#GO:0098609 integrin complex#GO:0008305;signaling receptor complex#GO:0043235;plasma membrane#GO:0005886;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;cell surface#GO:0009986;protein complex involved in cell adhesion#GO:0098636;cell periphery#GO:0071944;plasma membrane protein complex#GO:0098797;membrane#GO:0016020;membrane protein complex#GO:0098796 integrin#PC00126;cell adhesion molecule#PC00069 Integrin signalling pathway#P00034>Integrin alpha#P00941 HUMAN|HGNC=30891|UniProtKB=A8MYA2 A8MYA2 CXorf49 PTHR31866:SF5 GENE 4779-RELATED SUBFAMILY NOT NAMED HUMAN|HGNC=12185|UniProtKB=P01733 P01733 TRBV12-3 PTHR23268:SF14 T-CELL RECEPTOR BETA CHAIN T CELL RECEPTOR BETA VARIABLE 12-3-RELATED cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;biological regulation#GO:0065007;signaling#GO:0023052;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 defense/immunity protein#PC00090;immunoglobulin receptor superfamily#PC00124 HUMAN|HGNC=25991|UniProtKB=Q6NUM9 Q6NUM9 RETSAT PTHR46091:SF1 BLR7054 PROTEIN ALL-TRANS-RETINOL 13,14-REDUCTASE catalytic activity#GO:0003824;oxidoreductase activity#GO:0016491;oxidoreductase activity, acting on the CH-CH group of donors#GO:0016627 lipid metabolic process#GO:0006629;alcohol metabolic process#GO:0006066;metabolic process#GO:0008152;diterpenoid metabolic process#GO:0016101;retinoid metabolic process#GO:0001523;cellular process#GO:0009987;biological regulation#GO:0065007;hormone metabolic process#GO:0042445;terpenoid metabolic process#GO:0006721;retinol metabolic process#GO:0042572;olefinic compound metabolic process#GO:0120254;regulation of biological quality#GO:0065008;isoprenoid metabolic process#GO:0006720;regulation of hormone levels#GO:0010817;primary metabolic process#GO:0044238;small molecule metabolic process#GO:0044281 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;nuclear outer membrane-endoplasmic reticulum membrane network#GO:0042175;organelle#GO:0043226;membrane#GO:0016020;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;organelle subcompartment#GO:0031984;endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;endoplasmic reticulum subcompartment#GO:0098827;endoplasmic reticulum membrane#GO:0005789 HUMAN|HGNC=15924|UniProtKB=Q9UJQ4 Q9UJQ4 SALL4 PTHR23233:SF19 SAL-LIKE PROTEIN SAL-LIKE PROTEIN 4 DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;DNA-binding transcription factor activity#GO:0003700;transcription regulator activity#GO:0140110 regulation of biological process#GO:0050789;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889 intracellular organelle#GO:0043229;nucleus#GO:0005634;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165 zinc finger transcription factor#PC00244;C2H2 zinc finger transcription factor#PC00248;DNA-binding transcription factor#PC00218 HUMAN|HGNC=1738|UniProtKB=Q9Y5S2 Q9Y5S2 CDC42BPB PTHR22988:SF34 MYOTONIC DYSTROPHY S/T KINASE-RELATED SERINE_THREONINE-PROTEIN KINASE MRCK BETA catalytic activity#GO:0003824;transferase activity#GO:0016740;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;protein serine/threonine kinase activity#GO:0004674;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 cellular process#GO:0009987;cellular component organization#GO:0016043;organelle organization#GO:0006996;actomyosin structure organization#GO:0031032;cytoskeleton organization#GO:0007010;actin cytoskeleton organization#GO:0030036;actin filament-based process#GO:0030029;cellular component organization or biogenesis#GO:0071840 actin cytoskeleton#GO:0015629;actomyosin#GO:0042641;cellular anatomical structure#GO:0110165;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membraneless organelle#GO:0043232;cytoskeleton#GO:0005856;intracellular organelle#GO:0043229;membraneless organelle#GO:0043228;intracellular anatomical structure#GO:0005622 non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=12646|UniProtKB=O95183 O95183 VAMP5 PTHR47462:SF1 VESICLE-ASSOCIATED MEMBRANE PROTEIN 5 VESICLE-ASSOCIATED MEMBRANE PROTEIN 5 transport#GO:0006810;Golgi vesicle transport#GO:0048193;protein localization to cell periphery#GO:1990778;vesicle-mediated transport to the plasma membrane#GO:0098876;intracellular protein localization#GO:0008104;establishment of localization#GO:0051234;cellular process#GO:0009987;establishment of protein localization#GO:0045184;establishment of protein localization to membrane#GO:0090150;macromolecule localization#GO:0033036;vesicle-mediated transport#GO:0016192;establishment of protein localization to plasma membrane#GO:0061951;localization within membrane#GO:0051668;protein transport#GO:0015031;post-Golgi vesicle-mediated transport#GO:0006892;cellular localization#GO:0051641;localization#GO:0051179;protein localization to plasma membrane#GO:0072659;protein localization to membrane#GO:0072657;Golgi to plasma membrane protein transport#GO:0043001;Golgi to plasma membrane transport#GO:0006893 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 HUMAN|HGNC=22964|UniProtKB=Q9Y2W1 Q9Y2W1 THRAP3 PTHR15268:SF16 THRAP3/BCLAF1 THYROID HORMONE RECEPTOR-ASSOCIATED PROTEIN 3 transcription regulator activity#GO:0140110;transcription coregulator activity#GO:0003712;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA binding#GO:0003677 positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;positive regulation of macromolecule metabolic process#GO:0010604;regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of DNA-templated transcription#GO:0045893;positive regulation of RNA biosynthetic process#GO:1902680;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;mediator complex#GO:0016592;intracellular anatomical structure#GO:0005622;nuclear protein-containing complex#GO:0140513;nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165 DNA metabolism protein#PC00009 HUMAN|HGNC=11936|UniProtKB=P48023 P48023 FASLG PTHR11471:SF33 TUMOR NECROSIS FACTOR FAMILY MEMBER TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 6 molecular function activator activity#GO:0140677;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;cytokine activity#GO:0005125;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018 regulation of apoptotic signaling pathway#GO:2001233;cell communication#GO:0007154;cell death#GO:0008219;cellular response to stimulus#GO:0051716;regulation of extrinsic apoptotic signaling pathway#GO:2001236;positive regulation of signal transduction#GO:0009967;programmed cell death#GO:0012501;positive regulation of apoptotic signaling pathway#GO:2001235;regulation of cell communication#GO:0010646;regulation of cellular process#GO:0050794;positive regulation of cell communication#GO:0010647;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;positive regulation of extrinsic apoptotic signaling pathway#GO:2001238;apoptotic signaling pathway#GO:0097190;positive regulation of cellular process#GO:0048522;regulation of canonical NF-kappaB signal transduction#GO:0043122;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;positive regulation of response to stimulus#GO:0048584;regulation of signaling#GO:0023051;regulation of intracellular signal transduction#GO:1902531;positive regulation of signaling#GO:0023056;regulation of biological process#GO:0050789;apoptotic process#GO:0006915;regulation of programmed cell death#GO:0043067;signaling#GO:0023052;response to stimulus#GO:0050896;extrinsic apoptotic signaling pathway#GO:0097191;positive regulation of programmed cell death#GO:0043068;cell surface receptor signaling pathway#GO:0007166;regulation of apoptotic process#GO:0042981;positive regulation of apoptotic process#GO:0043065;positive regulation of canonical NF-kappaB signal transduction#GO:0043123;extrinsic apoptotic signaling pathway via death domain receptors#GO:0008625;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 intercellular signal molecule#PC00207 Apoptosis signaling pathway#P00006>FAS ligand#P00326;FAS signaling pathway#P00020>FasL#P00617 HUMAN|HGNC=888|UniProtKB=Q12756 Q12756 KIF1A PTHR24115:SF361 KINESIN-RELATED KINESIN-LIKE PROTEIN KIF1A cytoskeletal motor activity#GO:0003774;cytoskeletal protein binding#GO:0008092;hydrolase activity, acting on acid anhydrides#GO:0016817;plus-end-directed microtubule motor activity#GO:0008574;protein binding#GO:0005515;ATP-dependent activity#GO:0140657;binding#GO:0005488;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;isomerase activity#GO:0016853;ribonucleoside triphosphate phosphatase activity#GO:0017111;macromolecular conformation isomerase activity#GO:0120543;tubulin binding#GO:0015631;catalytic activity#GO:0003824;pyrophosphatase activity#GO:0016462;microtubule motor activity#GO:0003777;ATP hydrolysis activity#GO:0016887;hydrolase activity#GO:0016787;polypeptide conformation or assembly isomerase activity#GO:0120544;microtubule binding#GO:0008017 cytosolic transport#GO:0016482;microtubule-based movement#GO:0007018;establishment of organelle localization#GO:0051656;cellular localization#GO:0051641;localization#GO:0051179;retrograde axonal transport#GO:0008090;microtubule-based transport#GO:0099111;organelle localization#GO:0051640;axonal transport#GO:0098930;organelle transport along microtubule#GO:0072384;establishment of vesicle localization#GO:0051650;vesicle-mediated transport#GO:0016192;cytoskeleton-dependent intracellular transport#GO:0030705;cellular process#GO:0009987;establishment of localization in cell#GO:0051649;vesicle localization#GO:0051648;axo-dendritic transport#GO:0008088;microtubule-based process#GO:0007017;vesicle cytoskeletal trafficking#GO:0099518;transport along microtubule#GO:0010970;establishment of localization#GO:0051234;transport#GO:0006810;vesicle transport along microtubule#GO:0047496;intracellular transport#GO:0046907 cytoskeleton#GO:0005856;polymeric cytoskeletal fiber#GO:0099513;membraneless organelle#GO:0043228;microtubule cytoskeleton#GO:0015630;neuron projection#GO:0043005;microtubule associated complex#GO:0005875;protein-containing complex#GO:0032991;supramolecular polymer#GO:0099081;supramolecular complex#GO:0099080;cytoplasm#GO:0005737;somatodendritic compartment#GO:0036477;intracellular membraneless organelle#GO:0043232;dendrite#GO:0030425;intracellular organelle#GO:0043229;axon#GO:0030424;dendritic tree#GO:0097447;microtubule#GO:0005874;intracellular anatomical structure#GO:0005622;supramolecular fiber#GO:0099512;cellular anatomical structure#GO:0110165;organelle#GO:0043226;plasma membrane bounded cell projection#GO:0120025;cell projection#GO:0042995 microtubule binding motor protein#PC00156;microtubule or microtubule-binding cytoskeletal protein#PC00157 HUMAN|HGNC=28438|UniProtKB=Q8IYN6 Q8IYN6 UBALD2 PTHR31993:SF6 UBA-LIKE DOMAIN-CONTAINING PROTEIN 2 UBA-LIKE DOMAIN-CONTAINING PROTEIN 2 HUMAN|HGNC=18329|UniProtKB=P62699 P62699 YPEL5 PTHR13848:SF58 PROTEIN YIPPEE-LIKE CG15309-RELATED PROTEIN YIPPEE-LIKE 5 ubiquitin-protein ligase#PC00234;protein modifying enzyme#PC00260 HUMAN|HGNC=11160|UniProtKB=P62318 P62318 SNRPD3 PTHR23338:SF17 SMALL NUCLEAR RIBONUCLEOPROTEIN SM SMALL NUCLEAR RIBONUCLEOPROTEIN SM D3 RNA binding#GO:0003723;binding#GO:0005488;nucleic acid binding#GO:0003676 protein-containing complex organization#GO:0043933;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;protein-RNA complex organization#GO:0071826;RNA splicing#GO:0008380;metabolic process#GO:0008152;nucleobase-containing compound biosynthetic process#GO:0034654;RNA processing#GO:0006396;biosynthetic process#GO:0009058;nucleobase-containing compound metabolic process#GO:0006139;cellular component assembly#GO:0022607;gene expression#GO:0010467;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;mRNA processing#GO:0006397;cellular component biogenesis#GO:0044085;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile#GO:0000377;RNA metabolic process#GO:0016070;protein-RNA complex assembly#GO:0022618;nucleic acid biosynthetic process#GO:0141187;RNA splicing, via transesterification reactions#GO:0000375;RNA biosynthetic process#GO:0032774;mRNA metabolic process#GO:0016071;ribonucleoprotein complex biogenesis#GO:0022613;spliceosomal snRNP assembly#GO:0000387;protein-containing complex assembly#GO:0065003;mRNA splicing, via spliceosome#GO:0000398;primary metabolic process#GO:0044238;cellular component organization#GO:0016043;nucleic acid metabolic process#GO:0090304 catalytic complex#GO:1902494;intracellular organelle#GO:0043229;spliceosomal tri-snRNP complex#GO:0097526;ribonucleoprotein complex#GO:1990904;precatalytic spliceosome#GO:0071011;membrane-bounded organelle#GO:0043227;SMN-Sm protein complex#GO:0034719;intracellular anatomical structure#GO:0005622;spliceosomal snRNP complex#GO:0097525;spliceosomal complex#GO:0005681;U4 snRNP#GO:0005687;intracellular membrane-bounded organelle#GO:0043231;U2-type spliceosomal complex#GO:0005684;organelle#GO:0043226;cellular anatomical structure#GO:0110165;U2 snRNP#GO:0005686;nuclear protein-containing complex#GO:0140513;Sm-like protein family complex#GO:0120114;catalytic step 2 spliceosome#GO:0071013;U5 snRNP#GO:0005682;nucleus#GO:0005634;small nuclear ribonucleoprotein complex#GO:0030532;cytoplasm#GO:0005737;protein-containing complex#GO:0032991;U1 snRNP#GO:0005685 RNA splicing factor#PC00148;RNA metabolism protein#PC00031;RNA processing factor#PC00147 HUMAN|HGNC=9942|UniProtKB=P23942 P23942 PRPH2 PTHR19282:SF202 TETRASPANIN PERIPHERIN-2 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 scaffold/adaptor protein#PC00226 HUMAN|HGNC=13176|UniProtKB=Q13422 Q13422 IKZF1 PTHR24404:SF36 ZINC FINGER PROTEIN DNA-BINDING PROTEIN IKAROS sequence-specific double-stranded DNA binding#GO:1990837;sequence-specific DNA binding#GO:0043565;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;binding#GO:0005488;nucleic acid binding#GO:0003676;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978 regulation of RNA metabolic process#GO:0051252;regulation of gene expression#GO:0010468;regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of cellular process#GO:0050794;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of biological process#GO:0050789;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of primary metabolic process#GO:0080090 C2H2 zinc finger transcription factor#PC00248;zinc finger transcription factor#PC00244;DNA-binding transcription factor#PC00218 HUMAN|HGNC=28900|UniProtKB=Q9NP80 Q9NP80 PNPLA8 PTHR24185:SF10 CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA A2-type glycerophospholipase activity#GO:0004623;phospholipase activity#GO:0120569;hydrolase activity, acting on ester bonds#GO:0016788;glycerophospholipase activity#GO:0004620;catalytic activity#GO:0003824;hydrolase activity#GO:0016787;carboxylic ester hydrolase activity#GO:0052689;lipase activity#GO:0016298 cellular process#GO:0009987;arachidonate metabolic process#GO:0019369;monocarboxylic acid metabolic process#GO:0032787;long-chain fatty acid metabolic process#GO:0001676;primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;small molecule metabolic process#GO:0044281;icosanoid metabolic process#GO:0006690;unsaturated fatty acid metabolic process#GO:0033559;lipid metabolic process#GO:0006629;oxoacid metabolic process#GO:0043436;metabolic process#GO:0008152;olefinic compound metabolic process#GO:0120254;fatty acid metabolic process#GO:0006631 membrane#GO:0016020;cellular anatomical structure#GO:0110165 lipase#PC00143;phospholipase#PC00186;hydrolase#PC00121 HUMAN|HGNC=29067|UniProtKB=Q96AA8 Q96AA8 JAKMIP2 PTHR18935:SF7 GOLGIN SUBFAMILY A MEMBER 4-LIKE ISOFORM X1 JANUS KINASE AND MICROTUBULE-INTERACTING PROTEIN 2 HUMAN|HGNC=33278|UniProtKB=A6NI87 A6NI87 CBY3 PTHR21533:SF17 LEUCINE-RICH PROTEIN SPERM ANNULUS POSITIONING COMPLEX SUBUNIT CHIBBY3 HUMAN|HGNC=24793|UniProtKB=Q6ZS72 Q6ZS72 PEAK3 PTHR22972:SF6 SERINE/THREONINE PROTEIN KINASE PROTEIN PEAK3 transferase activity#GO:0016740;catalytic activity#GO:0003824;transferase activity, transferring phosphorus-containing groups#GO:0016772;kinase activity#GO:0016301;catalytic activity, acting on a protein#GO:0140096;phosphotransferase activity, alcohol group as acceptor#GO:0016773;protein kinase activity#GO:0004672 regulation of biological process#GO:0050789;biological regulation#GO:0065007;regulation of locomotion#GO:0040012;regulation of cell motility#GO:2000145;regulation of cellular process#GO:0050794 actin cytoskeleton#GO:0015629;cell-substrate junction#GO:0030055;focal adhesion#GO:0005925;intracellular membraneless organelle#GO:0043232;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;cytoskeleton#GO:0005856;intracellular anatomical structure#GO:0005622;anchoring junction#GO:0070161;membraneless organelle#GO:0043228;cell junction#GO:0030054 protein modifying enzyme#PC00260;non-receptor serine/threonine protein kinase#PC00167 HUMAN|HGNC=30403|UniProtKB=Q9H7N4 Q9H7N4 SCAF1 PTHR47013:SF1 SPLICING FACTOR, ARGININE/SERINE-RICH 19 SPLICING FACTOR, ARGININE_SERINE-RICH 19 RNA polymerase II complex binding#GO:0000993;protein binding#GO:0005515;RNA polymerase core enzyme binding#GO:0043175;binding#GO:0005488;enzyme binding#GO:0019899;RNA polymerase binding#GO:0070063 RNA metabolism protein#PC00031;RNA splicing factor#PC00148;RNA processing factor#PC00147 HUMAN|HGNC=24061|UniProtKB=Q86UN6 Q86UN6 AKAP14 PTHR35075:SF1 A-KINASE ANCHOR PROTEIN 14 A-KINASE ANCHOR PROTEIN 14 protein binding#GO:0005515;protein kinase A regulatory subunit binding#GO:0034237;protein kinase A binding#GO:0051018;binding#GO:0005488 protein-containing complex#GO:0032991;serine/threonine protein kinase complex#GO:1902554;protein kinase complex#GO:1902911;intracellular protein-containing complex#GO:0140535;transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;transferase complex#GO:1990234 scaffold/adaptor protein#PC00226 HUMAN|HGNC=14681|UniProtKB=Q9UM82 Q9UM82 SPATA2 PTHR15326:SF8 SPERMATOGENESIS-ASSOCIATED PROTEIN 2/TAMOZHENNIC SPERMATOGENESIS-ASSOCIATED PROTEIN 2 signaling adaptor activity#GO:0035591;signaling receptor complex adaptor activity#GO:0030159;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090 regulation of response to stimulus#GO:0048583;regulation of defense response#GO:0031347;regulation of inflammatory response#GO:0050727;regulation of signaling#GO:0023051;regulation of response to stress#GO:0080134;regulation of cytokine-mediated signaling pathway#GO:0001959;regulation of biological process#GO:0050789;regulation of programmed cell death#GO:0043067;regulation of response to cytokine stimulus#GO:0060759;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of cell communication#GO:0010646;regulation of response to external stimulus#GO:0032101;regulation of cellular process#GO:0050794 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165 HUMAN|HGNC=10981|UniProtKB=Q02978 Q02978 SLC25A11 PTHR45618:SF9 MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED MITOCHONDRIAL 2-OXOGLUTARATE_MALATE CARRIER PROTEIN transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;intracellular organelle#GO:0043229;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;mitochondrial envelope#GO:0005740;organelle inner membrane#GO:0019866;mitochondrial inner membrane#GO:0005743;organelle envelope#GO:0031967;membrane#GO:0016020 secondary carrier transporter#PC00258;transporter#PC00227 HUMAN|HGNC=53647|UniProtKB=A0A1B0GTW7 A0A1B0GTW7 CIROP PTHR10942:SF6 LEISHMANOLYSIN-LIKE PEPTIDASE CILIATED LEFT-RIGHT ORGANIZER METALLOPEPTIDASE peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096;catalytic activity#GO:0003824 cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622 protein modifying enzyme#PC00260;metalloprotease#PC00153;protease#PC00190 HUMAN|HGNC=16264|UniProtKB=Q12931 Q12931 TRAP1 PTHR11528:SF44 HEAT SHOCK PROTEIN 90 FAMILY MEMBER HEAT SHOCK PROTEIN 75 KDA, MITOCHONDRIAL-RELATED carbohydrate derivative binding#GO:0097367;purine ribonucleoside triphosphate binding#GO:0035639;purine nucleotide binding#GO:0017076;hydrolase activity, acting on acid anhydrides#GO:0016817;ribonucleotide binding#GO:0032553;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;nucleoside phosphate binding#GO:1901265;kinase binding#GO:0019900;ATP binding#GO:0005524;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides#GO:0016818;binding#GO:0005488;protein kinase binding#GO:0019901;ATP-dependent activity#GO:0140657;enzyme binding#GO:0019899;protein binding#GO:0005515;pyrophosphatase activity#GO:0016462;catalytic activity#GO:0003824;nucleotide binding#GO:0000166;ribonucleoside triphosphate phosphatase activity#GO:0017111;ion binding#GO:0043167;anion binding#GO:0043168;small molecule binding#GO:0036094;hydrolase activity#GO:0016787;ATP hydrolysis activity#GO:0016887 protein folding#GO:0006457;biosynthetic process#GO:0009058;gene expression#GO:0010467;protein maturation#GO:0051604;cellular process#GO:0009987;macromolecule biosynthetic process#GO:0009059;primary metabolic process#GO:0044238;protein metabolic process#GO:0019538;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152 intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;organelle inner membrane#GO:0019866;mitochondrial envelope#GO:0005740;mitochondrion#GO:0005739;mitochondrial membrane#GO:0031966;membrane#GO:0016020;organelle envelope#GO:0031967;mitochondrial inner membrane#GO:0005743;intracellular anatomical structure#GO:0005622;organelle membrane#GO:0031090;membrane-bounded organelle#GO:0043227;intracellular organelle#GO:0043229 chaperone#PC00072;Hsp90 family chaperone#PC00028 HUMAN|HGNC=25250|UniProtKB=Q9BRR6 Q9BRR6 ADPGK PTHR21208:SF0 ADP-DEPENDENT GLUCOKINASE ADP-DEPENDENT GLUCOKINASE catalytic activity#GO:0003824;transferase activity#GO:0016740;kinase activity#GO:0016301;transferase activity, transferring phosphorus-containing groups#GO:0016772;phosphotransferase activity, alcohol group as acceptor#GO:0016773 small molecule metabolic process#GO:0044281;carbohydrate metabolic process#GO:0005975;hexose metabolic process#GO:0019318;primary metabolic process#GO:0044238;cellular process#GO:0009987;glucose metabolic process#GO:0006006;monosaccharide metabolic process#GO:0005996;metabolic process#GO:0008152 endoplasmic reticulum#GO:0005783;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;endomembrane system#GO:0012505;organelle#GO:0043226;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 kinase#PC00137 HUMAN|HGNC=17245|UniProtKB=Q8N4T0 Q8N4T0 CPA6 PTHR11705:SF18 PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B CARBOXYPEPTIDASE A6 metallopeptidase activity#GO:0008237;carboxypeptidase activity#GO:0004180;exopeptidase activity#GO:0008238;hydrolase activity#GO:0016787;metallocarboxypeptidase activity#GO:0004181;metalloexopeptidase activity#GO:0008235;catalytic activity#GO:0003824;peptidase activity#GO:0008233;catalytic activity, acting on a protein#GO:0140096 cellular process#GO:0009987;metabolic process#GO:0008152;proteolysis#GO:0006508;primary metabolic process#GO:0044238;macromolecule metabolic process#GO:0043170;protein metabolic process#GO:0019538 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 metalloprotease#PC00153 HUMAN|HGNC=4039|UniProtKB=Q9ULW2 Q9ULW2 FZD10 PTHR11309:SF86 FRIZZLED FRIZZLED-10 transmembrane signaling receptor activity#GO:0004888;binding#GO:0005488;signaling receptor activity#GO:0038023;Wnt-protein binding#GO:0017147;protein binding#GO:0005515;molecular transducer activity#GO:0060089 cell surface receptor signaling pathway#GO:0007166;cell communication#GO:0007154;canonical Wnt signaling pathway#GO:0060070;non-canonical Wnt signaling pathway#GO:0035567;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;Wnt signaling pathway#GO:0016055;response to stimulus#GO:0050896;signaling#GO:0023052;biological regulation#GO:0065007 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 Alzheimer disease-presenilin pathway#P00004>Frizzled#P00119;Wnt signaling pathway#P00057>Frizzled#P01428;Cadherin signaling pathway#P00012>Frizzled#P00475 HUMAN|HGNC=14310|UniProtKB=Q9NPI1 Q9NPI1 BRD7 PTHR22881:SF12 BROMODOMAIN CONTAINING PROTEIN BROMODOMAIN-CONTAINING PROTEIN 7 chromatin-protein adaptor activity#GO:0140463;protein-macromolecule adaptor activity#GO:0030674;molecular adaptor activity#GO:0060090;histone reader activity#GO:0140566 regulation of biosynthetic process#GO:0009889;regulation of DNA-templated transcription#GO:0006355;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252;regulation of cellular process#GO:0050794;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;biological regulation#GO:0065007;regulation of RNA biosynthetic process#GO:2001141;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;regulation of primary metabolic process#GO:0080090;regulation of biological process#GO:0050789 nucleus#GO:0005634;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;intracellular membrane-bounded organelle#GO:0043231;membrane-bounded organelle#GO:0043227;cellular anatomical structure#GO:0110165;organelle#GO:0043226 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=25878|UniProtKB=Q6MZQ0 Q6MZQ0 PRR5L PTHR32428:SF3 TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT BIT61-RELATED PROLINE-RICH PROTEIN 5-LIKE enzyme regulator activity#GO:0030234;protein kinase regulator activity#GO:0019887;molecular function regulator activity#GO:0098772;kinase regulator activity#GO:0019207 positive regulation of response to stimulus#GO:0048584;regulation of signal transduction#GO:0009966;biological regulation#GO:0065007;TOR signaling#GO:0031929;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;signal transduction#GO:0007165;cellular process#GO:0009987;positive regulation of intracellular signal transduction#GO:1902533;regulation of response to stimulus#GO:0048583;positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051897;response to stimulus#GO:0050896;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;signaling#GO:0023052;regulation of cell communication#GO:0010646;TORC2 signaling#GO:0038203;positive regulation of signal transduction#GO:0009967;regulation of biological process#GO:0050789;cellular response to stimulus#GO:0051716;cell communication#GO:0007154;positive regulation of signaling#GO:0023056;regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction#GO:0051896;intracellular signal transduction#GO:0035556;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051 protein-containing complex#GO:0032991;intracellular protein-containing complex#GO:0140535;TOR complex#GO:0038201 HUMAN|HGNC=6818|UniProtKB=Q13021 Q13021 MALL PTHR22776:SF24 MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN MAL-LIKE PROTEIN regulation of biological process#GO:0050789;signaling#GO:0023052;biological regulation#GO:0065007 intracellular organelle#GO:0043229;membrane microdomain#GO:0098857;membrane-bounded organelle#GO:0043227;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;vesicle#GO:0031982;cell periphery#GO:0071944;intracellular vesicle#GO:0097708;membrane#GO:0016020;membrane raft#GO:0045121;plasma membrane#GO:0005886;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;organelle#GO:0043226;cellular anatomical structure#GO:0110165 scaffold/adaptor protein#PC00226 HUMAN|HGNC=25505|UniProtKB=Q9H8J5 Q9H8J5 MANSC1 PTHR16021:SF7 MANSC DOMAIN CONTAINING PROTEIN 1 MANSC DOMAIN-CONTAINING PROTEIN 1 intracellular organelle#GO:0043229;Golgi apparatus#GO:0005794;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;endomembrane system#GO:0012505;cellular anatomical structure#GO:0110165;organelle#GO:0043226 HUMAN|HGNC=9593|UniProtKB=P34995 P34995 PTGER1 PTHR11866:SF3 G-PROTEIN COUPLED RECEPTOR FAMILY 1 MEMBER PROSTAGLANDIN E2 RECEPTOR EP1 SUBTYPE transmembrane signaling receptor activity#GO:0004888;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089;G protein-coupled receptor activity#GO:0004930 cell communication#GO:0007154;regulation of biological quality#GO:0065008;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;positive regulation of cytosolic calcium ion concentration#GO:0007204;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;response to stimulus#GO:0050896;regulation of cellular process#GO:0050794;signaling#GO:0023052;biological regulation#GO:0065007;signal transduction#GO:0007165;regulation of biological process#GO:0050789;cellular process#GO:0009987;cellular response to stimulus#GO:0051716 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 transmembrane signal receptor#PC00197;G-protein coupled receptor#PC00021 PI3 kinase pathway#P00048>GPCR#P01204;Gonadotropin-releasing hormone receptor pathway#P06664>PG Rcs#P06836 HUMAN|HGNC=15936|UniProtKB=Q14686 Q14686 NCOA6 PTHR15690:SF0 NUCLEAR RECEPTOR COACTIVATOR 6 NUCLEAR RECEPTOR COACTIVATOR 6 transcription coregulator activity#GO:0003712;transcription regulator activity#GO:0140110;transcription coactivator activity#GO:0003713 regulation of nucleobase-containing compound metabolic process#GO:0019219;positive regulation of macromolecule metabolic process#GO:0010604;positive regulation of DNA-templated transcription#GO:0045893;regulation of RNA biosynthetic process#GO:2001141;positive regulation of RNA biosynthetic process#GO:1902680;biological regulation#GO:0065007;regulation of primary metabolic process#GO:0080090;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;positive regulation of biological process#GO:0048518;positive regulation of cellular process#GO:0048522;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;positive regulation of transcription by RNA polymerase II#GO:0045944;regulation of transcription by RNA polymerase II#GO:0006357;regulation of macromolecule metabolic process#GO:0060255;regulation of cellular process#GO:0050794;positive regulation of RNA metabolic process#GO:0051254;regulation of biological process#GO:0050789;positive regulation of macromolecule biosynthetic process#GO:0010557;positive regulation of biosynthetic process#GO:0009891;positive regulation of metabolic process#GO:0009893;regulation of DNA-templated transcription#GO:0006355;regulation of RNA metabolic process#GO:0051252 intracellular organelle lumen#GO:0070013;catalytic complex#GO:1902494;intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;organelle lumen#GO:0043233;nucleoplasm#GO:0005654;organelle#GO:0043226;methyltransferase complex#GO:0034708;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;transferase complex#GO:1990234;histone methyltransferase complex#GO:0035097;nuclear protein-containing complex#GO:0140513;transcription regulator complex#GO:0005667;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;protein-containing complex#GO:0032991 chromatin/chromatin-binding, or -regulatory protein#PC00077 HUMAN|HGNC=12775|UniProtKB=O00744 O00744 WNT10B PTHR12027:SF76 WNT RELATED PROTEIN WNT-10B molecular function activator activity#GO:0140677;protein binding#GO:0005515;signaling receptor binding#GO:0005102;binding#GO:0005488;cytokine activity#GO:0005125;molecular function regulator activity#GO:0098772;signaling receptor activator activity#GO:0030546;G protein-coupled receptor binding#GO:0001664;frizzled binding#GO:0005109;signaling receptor regulator activity#GO:0030545;receptor ligand activity#GO:0048018 regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;cell differentiation#GO:0030154;Wnt signaling pathway#GO:0016055;signaling#GO:0023052;cellular response to stimulus#GO:0051716;regulation of biological process#GO:0050789;anatomical structure development#GO:0048856;cell communication#GO:0007154;canonical Wnt signaling pathway#GO:0060070;system development#GO:0048731;cell fate commitment#GO:0045165;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;multicellular organismal process#GO:0032501;nervous system development#GO:0007399;biological regulation#GO:0065007;cellular process#GO:0009987;signal transduction#GO:0007165;cellular developmental process#GO:0048869;multicellular organism development#GO:0007275;neurogenesis#GO:0022008;cell surface receptor signaling pathway#GO:0007166;neuron differentiation#GO:0030182;developmental process#GO:0032502 extracellular region#GO:0005576;cellular anatomical structure#GO:0110165 intercellular signal molecule#PC00207 Alzheimer disease-presenilin pathway#P00004>Wnt#P00142;Wnt signaling pathway#P00057>Wnt#P01444;Cadherin signaling pathway#P00012>Wnt#P00474;Angiogenesis#P00005>Wnt#P00206 HUMAN|HGNC=34296|UniProtKB=Q05C16 Q05C16 LRRC63 PTHR48051:SF75 FAMILY NOT NAMED LEUCINE-RICH REPEAT-CONTAINING PROTEIN 63 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=20130|UniProtKB=Q8NBD8 Q8NBD8 TMEM229B PTHR31746:SF3 TRANSMEMBRANE PROTEIN 229 FAMILY MEMBER TRANSMEMBRANE PROTEIN 229B HUMAN|HGNC=8700|UniProtKB=Q9Y5H1 Q9Y5H1 PCDHGA2 PTHR24028:SF134 CADHERIN-87A PROTOCADHERIN GAMMA-A2 cell adhesion#GO:0007155;cellular process#GO:0009987 cell periphery#GO:0071944;membrane#GO:0016020;plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165 cadherin#PC00057;cell adhesion molecule#PC00069 Cadherin signaling pathway#P00012>Cadherin#P00471;Wnt signaling pathway#P00057>Cadherin#P01440 HUMAN|HGNC=11127|UniProtKB=Q9BZZ2 Q9BZZ2 SIGLEC1 PTHR47243:SF1 SIALOADHESIN SIALOADHESIN binding#GO:0005488;protein binding#GO:0005515 biological process involved in interaction with host#GO:0051701;biological process involved in interspecies interaction between organisms#GO:0044419;endocytosis#GO:0006897;vesicle-mediated transport#GO:0016192;cellular process#GO:0009987;clathrin-dependent endocytosis#GO:0072583;biological process involved in symbiotic interaction#GO:0044403;receptor-mediated endocytosis#GO:0006898;establishment of localization#GO:0051234;import into cell#GO:0098657;localization#GO:0051179;transport#GO:0006810 plasma membrane#GO:0005886;cytoplasm#GO:0005737;late endosome#GO:0005770;endomembrane system#GO:0012505;cell periphery#GO:0071944;membrane#GO:0016020;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;cellular anatomical structure#GO:0110165;vesicle#GO:0031982;intracellular vesicle#GO:0097708;membrane-bounded organelle#GO:0043227;early endosome#GO:0005769;cytoplasmic vesicle#GO:0031410;intracellular anatomical structure#GO:0005622;intracellular organelle#GO:0043229;endosome#GO:0005768 HUMAN|HGNC=27912|UniProtKB=Q6ZMM2 Q6ZMM2 ADAMTSL5 PTHR13723:SF173 ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE ADAMTS-LIKE PROTEIN 5 metallopeptidase activity#GO:0008237;catalytic activity#GO:0003824;metalloendopeptidase activity#GO:0004222;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096 extracellular structure organization#GO:0043062;proteolysis#GO:0006508;metabolic process#GO:0008152;external encapsulating structure organization#GO:0045229;extracellular matrix organization#GO:0030198;protein metabolic process#GO:0019538;cellular component organization or biogenesis#GO:0071840;macromolecule metabolic process#GO:0043170;cellular process#GO:0009987;primary metabolic process#GO:0044238;cellular component organization#GO:0016043 extracellular region#GO:0005576;extracellular matrix#GO:0031012;external encapsulating structure#GO:0030312;cellular anatomical structure#GO:0110165 metalloprotease#PC00153 HUMAN|HGNC=17646|UniProtKB=Q96IV0 Q96IV0 NGLY1 PTHR12143:SF45 PEPTIDE N-GLYCANASE PNGASE -RELATED PEPTIDE-N(4)-(N-ACETYL-BETA-GLUCOSAMINYL)ASPARAGINE AMIDASE hydrolase activity#GO:0016787;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds#GO:0016810;catalytic activity#GO:0003824;hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides#GO:0016811 macromolecule metabolic process#GO:0043170;positive regulation of BMP signaling pathway#GO:0030513;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;glycoprotein metabolic process#GO:0009100;regulation of response to stimulus#GO:0048583;positive regulation of response to stimulus#GO:0048584;regulation of signal transduction#GO:0009966;regulation of cellular response to growth factor stimulus#GO:0090287;biological regulation#GO:0065007;regulation of BMP signaling pathway#GO:0030510;carbohydrate derivative metabolic process#GO:1901135;positive regulation of cellular process#GO:0048522;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;positive regulation of signaling#GO:0023056;protein metabolic process#GO:0019538;protein catabolic process#GO:0030163;regulation of signaling#GO:0023051;catabolic process#GO:0009056;positive regulation of cell communication#GO:0010647;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;carbohydrate derivative catabolic process#GO:1901136;regulation of transmembrane receptor protein serine/threonine kinase signaling pathway#GO:0090092;positive regulation of signal transduction#GO:0009967;primary metabolic process#GO:0044238;regulation of biological process#GO:0050789 nucleus#GO:0005634;cytosol#GO:0005829;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 metabolite interconversion enzyme#PC00262;hydrolase#PC00121 Oxidative stress response#P00046>TRX#P01122;Hypoxia response via HIF activation#P00030>Thioredoxin#P00825 HUMAN|HGNC=9958|UniProtKB=P00797 P00797 REN PTHR47966:SF24 BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED RENIN aspartic-type endopeptidase activity#GO:0004190;catalytic activity#GO:0003824;endopeptidase activity#GO:0004175;peptidase activity#GO:0008233;hydrolase activity#GO:0016787;catalytic activity, acting on a protein#GO:0140096 regulation of hormone levels#GO:0010817;primary metabolic process#GO:0044238;regulation of biological quality#GO:0065008;signaling receptor ligand precursor processing#GO:0140448;protein metabolic process#GO:0019538;proteolysis#GO:0006508;circulatory system process#GO:0003013;biological regulation#GO:0065007;biosynthetic process#GO:0009058;blood circulation#GO:0008015;hormone metabolic process#GO:0042445;protein maturation#GO:0051604;gene expression#GO:0010467;multicellular organismal process#GO:0032501;macromolecule biosynthetic process#GO:0009059;cellular process#GO:0009987;protein processing#GO:0016485;peptide hormone processing#GO:0016486;regulation of blood pressure#GO:0008217;regulation of systemic arterial blood pressure#GO:0003073;system process#GO:0003008;macromolecule metabolic process#GO:0043170;metabolic process#GO:0008152 cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease#PC00190;aspartic protease#PC00053 HUMAN|HGNC=29681|UniProtKB=Q9BSK2 Q9BSK2 SLC25A33 PTHR45829:SF5 MITOCHONDRIAL CARRIER PROTEIN RIM2 SOLUTE CARRIER FAMILY 25 MEMBER 33 organophosphate ester transmembrane transporter activity#GO:0015605;nucleobase-containing compound transmembrane transporter activity#GO:0015932;transmembrane transporter activity#GO:0022857;transporter activity#GO:0005215 localization#GO:0051179;establishment of localization#GO:0051234;transmembrane transport#GO:0055085;transport#GO:0006810;nucleobase-containing compound transport#GO:0015931;organophosphate ester transport#GO:0015748;nitrogen compound transport#GO:0071705;cellular process#GO:0009987 intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;mitochondrion#GO:0005739;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231;cellular anatomical structure#GO:0110165;organelle#GO:0043226 mitochondrial carrier protein#PC00158;secondary carrier transporter#PC00258 HUMAN|HGNC=19767|UniProtKB=Q8WXK1 Q8WXK1 ASB15 PTHR24118:SF101 POTE ANKYRIN DOMAIN ANKYRIN REPEAT AND SOCS BOX PROTEIN 15 transcription regulator activity#GO:0140110;transcription corepressor activity#GO:0003714;transcription coregulator activity#GO:0003712 regulation of non-canonical NF-kappaB signal transduction#GO:1901222;regulation of biological process#GO:0050789;regulation of cellular process#GO:0050794;regulation of cell communication#GO:0010646;biological regulation#GO:0065007;regulation of signal transduction#GO:0009966;regulation of intracellular signal transduction#GO:1902531;regulation of signaling#GO:0023051;regulation of response to stimulus#GO:0048583 membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular protein-containing complex#GO:0140535;intracellular organelle#GO:0043229;intracellular membrane-bounded organelle#GO:0043231;organelle#GO:0043226;protein-containing complex#GO:0032991;cellular anatomical structure#GO:0110165;nucleus#GO:0005634 membrane traffic protein#PC00150 HUMAN|HGNC=27723|UniProtKB=Q3SXM0 Q3SXM0 DCAF4L1 PTHR44472:SF2 DDB1- AND CUL4-ASSOCIATED FACTOR 4-RELATED DDB1- AND CUL4-ASSOCIATED FACTOR 4-LIKE PROTEIN 1 catalytic complex#GO:1902494;transferase complex#GO:1990234;Cul4-RING E3 ubiquitin ligase complex#GO:0080008;protein-containing complex#GO:0032991;ubiquitin ligase complex#GO:0000151;cullin-RING ubiquitin ligase complex#GO:0031461;intracellular protein-containing complex#GO:0140535 HUMAN|HGNC=25109|UniProtKB=B2RBV5 B2RBV5 MRFAP1L2 PTHR31324:SF3 MORF4 FAMILY-ASSOCIATED PROTEIN 1-RELATED MORF4 FAMILY ASSOCIATED PROTEIN 1 LIKE 2 HUMAN|HGNC=9388|UniProtKB=P10644 P10644 PRKAR1A PTHR11635:SF129 CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT kinase binding#GO:0019900;binding#GO:0005488;nucleoside phosphate binding#GO:1901265;enzyme binding#GO:0019899;protein kinase binding#GO:0019901;enzyme regulator activity#GO:0030234;protein binding#GO:0005515;molecular function inhibitor activity#GO:0140678;protein kinase A binding#GO:0051018;purine nucleotide binding#GO:0017076;carbohydrate derivative binding#GO:0097367;ribonucleotide binding#GO:0032553;kinase inhibitor activity#GO:0019210;purine ribonucleotide binding#GO:0032555;heterocyclic compound binding#GO:1901363;protein kinase regulator activity#GO:0019887;kinase regulator activity#GO:0019207;anion binding#GO:0043168;small molecule binding#GO:0036094;ion binding#GO:0043167;enzyme inhibitor activity#GO:0004857;molecular function regulator activity#GO:0098772;nucleotide binding#GO:0000166;protein kinase inhibitor activity#GO:0004860 cell communication#GO:0007154;G protein-coupled receptor signaling pathway#GO:0007186;adenylate cyclase-activating G protein-coupled receptor signaling pathway#GO:0007189;adenylate cyclase-modulating G protein-coupled receptor signaling pathway#GO:0007188;regulation of cellular process#GO:0050794;response to stimulus#GO:0050896;biological regulation#GO:0065007;signaling#GO:0023052;cellular response to stimulus#GO:0051716;cellular process#GO:0009987;signal transduction#GO:0007165;regulation of biological process#GO:0050789 transferase complex, transferring phosphorus-containing groups#GO:0061695;catalytic complex#GO:1902494;transferase complex#GO:1990234;intracellular anatomical structure#GO:0005622;protein kinase complex#GO:1902911;intracellular protein-containing complex#GO:0140535;serine/threonine protein kinase complex#GO:1902554;cytosol#GO:0005829;cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737 kinase modulator#PC00140;protein-binding activity modulator#PC00095 Endothelin signaling pathway#P00019>PKA#P00570;GABA-B receptor II signaling#P05731>PKA#P05752;Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway#P00026>PKA-r#P00700;Metabotropic glutamate receptor group II pathway#P00040>PKA#P01050;Metabotropic glutamate receptor group III pathway#P00039>PKA#P01035;Muscarinic acetylcholine receptor 2 and 4 signaling pathway#P00043>PKA#P01075;Transcription regulation by bZIP transcription factor#P00055>PKA#P01384;Hedgehog signaling pathway#P00025>PKA#P00682;Metabotropic glutamate receptor group I pathway#P00041>PKA#P01059 HUMAN|HGNC=20944|UniProtKB=Q9GZR1 Q9GZR1 SENP6 PTHR46896:SF1 SENTRIN-SPECIFIC PROTEASE SENTRIN-SPECIFIC PROTEASE 6 hydrolase activity#GO:0016787;cysteine-type peptidase activity#GO:0008234;catalytic activity#GO:0003824;catalytic activity, acting on a protein#GO:0140096;ubiquitin-like protein peptidase activity#GO:0019783;cysteine-type endopeptidase activity#GO:0004197;peptidase activity#GO:0008233;endopeptidase activity#GO:0004175 metabolic process#GO:0008152;regulation of chromosome organization#GO:0033044;macromolecule metabolic process#GO:0043170;regulation of organelle assembly#GO:1902115;cellular process#GO:0009987;biological regulation#GO:0065007;regulation of cell cycle process#GO:0010564;regulation of microtubule cytoskeleton organization#GO:0070507;post-translational protein modification#GO:0043687;protein modification by small protein conjugation or removal#GO:0070647;regulation of microtubule-based process#GO:0032886;macromolecule modification#GO:0043412;regulation of spindle assembly#GO:0090169;protein metabolic process#GO:0019538;primary metabolic process#GO:0044238;protein modification process#GO:0036211;regulation of protein-containing complex assembly#GO:0043254;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;regulation of spindle organization#GO:0090224;regulation of cytoskeleton organization#GO:0051493;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;regulation of cell cycle#GO:0051726;regulation of cellular component biogenesis#GO:0044087 nucleus#GO:0005634;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular organelle#GO:0043229;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 protease#PC00190;cysteine protease#PC00081 HUMAN|HGNC=8266|UniProtKB=Q8NH16 Q8NH16 OR2L2 PTHR26453:SF645 OLFACTORY RECEPTOR OLFACTORY RECEPTOR 2L2 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;signaling receptor activity#GO:0038023;molecular transducer activity#GO:0060089 sensory perception of chemical stimulus#GO:0007606;detection of chemical stimulus involved in sensory perception#GO:0050907;nervous system process#GO:0050877;sensory perception#GO:0007600;system process#GO:0003008;detection of stimulus involved in sensory perception#GO:0050906;detection of stimulus#GO:0051606;detection of chemical stimulus#GO:0009593;sensory perception of smell#GO:0007608;multicellular organismal process#GO:0032501;response to stimulus#GO:0050896;response to chemical#GO:0042221 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transmembrane signal receptor#PC00197 HUMAN|HGNC=38695|UniProtKB=P0CJ79 P0CJ79 ZNF888 PTHR24377:SF853 IP01015P-RELATED ZINC FINGER PROTEIN 888 sequence-specific DNA binding#GO:0043565;sequence-specific double-stranded DNA binding#GO:1990837;transcription cis-regulatory region binding#GO:0000976;transcription regulator activity#GO:0140110;RNA polymerase II transcription regulatory region sequence-specific DNA binding#GO:0000977;DNA-binding transcription factor activity#GO:0003700;nucleic acid binding#GO:0003676;binding#GO:0005488;DNA-binding transcription factor activity, RNA polymerase II-specific#GO:0000981;double-stranded DNA binding#GO:0003690;RNA polymerase II cis-regulatory region sequence-specific DNA binding#GO:0000978;cis-regulatory region sequence-specific DNA binding#GO:0000987;DNA binding#GO:0003677;transcription regulatory region nucleic acid binding#GO:0001067 regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of nucleobase-containing compound metabolic process#GO:0019219;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;regulation of RNA biosynthetic process#GO:2001141;biological regulation#GO:0065007;regulation of DNA-templated transcription#GO:0006355;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;regulation of RNA metabolic process#GO:0051252 intracellular organelle#GO:0043229;nucleus#GO:0005634;organelle#GO:0043226;cellular anatomical structure#GO:0110165;membrane-bounded organelle#GO:0043227;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622 C2H2 zinc finger transcription factor#PC00248 HUMAN|HGNC=32296|UniProtKB=Q6P047 Q6P047 C8orf74 PTHR28457:SF2 COILED-COIL DOMAIN-CONTAINING PROTEIN 189 SIMILAR TO HUMAN CHROMOSOME 8 OPEN READING FRAME 74 HUMAN|HGNC=16770|UniProtKB=Q8NFY4 Q8NFY4 SEMA6D PTHR11036:SF65 SEMAPHORIN SEMAPHORIN-6D receptor ligand activity#GO:0048018;signaling receptor regulator activity#GO:0030545;signaling receptor activator activity#GO:0030546;molecular function regulator activity#GO:0098772;binding#GO:0005488;signaling receptor binding#GO:0005102;protein binding#GO:0005515;molecular function activator activity#GO:0140677 cellular developmental process#GO:0048869;positive regulation of locomotion#GO:0040017;neuron projection guidance#GO:0097485;neurogenesis#GO:0022008;regulation of cell migration#GO:0030334;developmental process#GO:0032502;neuron projection morphogenesis#GO:0048812;multicellular organismal process#GO:0032501;biological regulation#GO:0065007;plasma membrane bounded cell projection organization#GO:0120036;regulation of locomotion#GO:0040012;axon development#GO:0061564;axon guidance#GO:0007411;positive regulation of cellular process#GO:0048522;positive regulation of cell migration#GO:0030335;cell communication#GO:0007154;regulation of cell motility#GO:2000145;anatomical structure development#GO:0048856;system development#GO:0048731;regulation of cellular process#GO:0050794;cellular response to stimulus#GO:0051716;multicellular organism development#GO:0007275;cellular component organization or biogenesis#GO:0071840;cell projection morphogenesis#GO:0048858;neuron differentiation#GO:0030182;cell surface receptor signaling pathway#GO:0007166;plasma membrane bounded cell projection morphogenesis#GO:0120039;cell morphogenesis involved in neuron differentiation#GO:0048667;nervous system development#GO:0007399;neuron projection development#GO:0031175;signal transduction#GO:0007165;positive regulation of biological process#GO:0048518;cellular process#GO:0009987;axonogenesis#GO:0007409;neuron development#GO:0048666;animal gross anatomical part developmental process#GO:0160108;generation of neurons#GO:0048699;cell projection organization#GO:0030030;cell differentiation#GO:0030154;response to stimulus#GO:0050896;cell morphogenesis#GO:0000902;signaling#GO:0023052;cell development#GO:0048468;positive regulation of cell motility#GO:2000147;cellular component organization#GO:0016043;anatomical structure morphogenesis#GO:0009653;regulation of biological process#GO:0050789 membrane#GO:0016020;cell periphery#GO:0071944;cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886 membrane-bound signaling molecule#PC00152 HUMAN|HGNC=8955|UniProtKB=P50453 P50453 SERPINB9 PTHR11461:SF350 SERINE PROTEASE INHIBITOR, SERPIN SERPIN B9 enzyme inhibitor activity#GO:0004857;molecular function regulator activity#GO:0098772;endopeptidase inhibitor activity#GO:0004866;peptidase regulator activity#GO:0061134;peptidase inhibitor activity#GO:0030414;endopeptidase regulator activity#GO:0061135;serine-type endopeptidase inhibitor activity#GO:0004867;molecular function inhibitor activity#GO:0140678;enzyme regulator activity#GO:0030234 cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;cellular anatomical structure#GO:0110165;extracellular region#GO:0005576 protease inhibitor#PC00191 HUMAN|HGNC=6041|UniProtKB=A1L0T0 A1L0T0 HACL2 PTHR18968:SF166 THIAMINE PYROPHOSPHATE ENZYMES 2-HYDROXYACYL-COA LYASE 2 anion binding#GO:0043168;binding#GO:0005488;flavin adenine dinucleotide binding#GO:0050660;small molecule binding#GO:0036094;nucleoside phosphate binding#GO:1901265;ion binding#GO:0043167;heterocyclic compound binding#GO:1901363;nucleotide binding#GO:0000166;catalytic activity#GO:0003824;transferase activity#GO:0016740;transketolase or transaldolase activity#GO:0016744 primary metabolic process#GO:0044238;carboxylic acid metabolic process#GO:0019752;carboxylic acid biosynthetic process#GO:0046394;cellular process#GO:0009987;small molecule metabolic process#GO:0044281;proteinogenic amino acid metabolic process#GO:0170039;biosynthetic process#GO:0009058;amino acid metabolic process#GO:0006520;metabolic process#GO:0008152;oxoacid metabolic process#GO:0043436;amino acid biosynthetic process#GO:0008652;branched-chain amino acid biosynthetic process#GO:0009082;small molecule biosynthetic process#GO:0044283;proteinogenic amino acid biosynthetic process#GO:0170038 cellular anatomical structure#GO:0110165;protein-containing complex#GO:0032991;cytoplasm#GO:0005737;intracellular anatomical structure#GO:0005622;catalytic complex#GO:1902494;transferase complex#GO:1990234 ligase#PC00142;metabolite interconversion enzyme#PC00262 Valine biosynthesis#P02785>Acetolactate synthase#P03216;Isoleucine biosynthesis#P02748>Acetolactate synthase#P02997 HUMAN|HGNC=26442|UniProtKB=Q96DE0 Q96DE0 NUDT16 PTHR31699:SF5 NUDIX T16 FAMILY MEMBER U8 SNORNA-DECAPPING ENZYME binding#GO:0005488;nucleic acid binding#GO:0003676;nuclease activity#GO:0004518;RNA binding#GO:0003723;hydrolase activity#GO:0016787;hydrolase activity, acting on ester bonds#GO:0016788;snoRNA binding#GO:0030515;catalytic activity#GO:0003824;catalytic activity, acting on a nucleic acid#GO:0140640;RNA endonuclease activity#GO:0004521;catalytic activity, acting on RNA#GO:0140098;RNA nuclease activity#GO:0004540;endonuclease activity#GO:0004519 macromolecule metabolic process#GO:0043170;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;metabolic process#GO:0008152;macromolecule catabolic process#GO:0009057;negative regulation of cellular process#GO:0048523;biological regulation#GO:0065007;nucleobase-containing compound metabolic process#GO:0006139;negative regulation of biosynthetic process#GO:0009890;negative regulation of macromolecule biosynthetic process#GO:0010558;nucleobase-containing compound catabolic process#GO:0034655;mRNA catabolic process#GO:0006402;regulation of metabolic process#GO:0019222;regulation of macromolecule biosynthetic process#GO:0010556;negative regulation of macromolecule metabolic process#GO:0010605;nucleic acid catabolic process#GO:0141188;cellular process#GO:0009987;RNA metabolic process#GO:0016070;RNA catabolic process#GO:0006401;regulation of macromolecule metabolic process#GO:0060255;catabolic process#GO:0009056;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;mRNA metabolic process#GO:0016071;negative regulation of biological process#GO:0048519;negative regulation of gene expression#GO:0010629;primary metabolic process#GO:0044238;nucleic acid metabolic process#GO:0090304;regulation of biological process#GO:0050789 nucleus#GO:0005634;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227 HUMAN|HGNC=24197|UniProtKB=Q96S95 Q96S95 CAMK2N2 PTHR31007:SF1 CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE II INHIBITOR 2 CALCIUM_CALMODULIN-DEPENDENT PROTEIN KINASE II INHIBITOR 2 enzyme inhibitor activity#GO:0004857;kinase inhibitor activity#GO:0019210;kinase regulator activity#GO:0019207;molecular function regulator activity#GO:0098772;protein kinase inhibitor activity#GO:0004860;protein kinase regulator activity#GO:0019887;kinase binding#GO:0019900;binding#GO:0005488;protein kinase binding#GO:0019901;enzyme binding#GO:0019899;protein binding#GO:0005515;enzyme regulator activity#GO:0030234;molecular function inhibitor activity#GO:0140678 kinase inhibitor#PC00139 HUMAN|HGNC=23520|UniProtKB=Q7RTY1 Q7RTY1 SLC16A9 PTHR11360:SF158 MONOCARBOXYLATE TRANSPORTER MONOCARBOXYLATE TRANSPORTER 9 monocarboxylic acid transmembrane transporter activity#GO:0008028;transmembrane transporter activity#GO:0022857;carboxylic acid transmembrane transporter activity#GO:0046943;transporter activity#GO:0005215 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020 transporter#PC00227 HUMAN|HGNC=15231|UniProtKB=Q8NH56 Q8NH56 OR52N5 PTHR26450:SF18 OLFACTORY RECEPTOR 56B1-RELATED OLFACTORY RECEPTOR 52N5 transmembrane signaling receptor activity#GO:0004888;olfactory receptor activity#GO:0004984;molecular transducer activity#GO:0060089;signaling receptor activity#GO:0038023 cellular anatomical structure#GO:0110165;plasma membrane#GO:0005886;membrane#GO:0016020;cell periphery#GO:0071944 transmembrane signal receptor#PC00197 HUMAN|HGNC=24002|UniProtKB=Q9H6S1 Q9H6S1 AZI2 PTHR14432:SF6 PROSAPIP2 PROTEIN/5-AZACYTIDINE INDUCED GENE 2 5-AZACYTIDINE-INDUCED PROTEIN 2 intracellular anatomical structure#GO:0005622;cytoplasm#GO:0005737;cellular anatomical structure#GO:0110165 HUMAN|HGNC=8092|UniProtKB=Q3MII6 Q3MII6 TBC1D25 PTHR22957:SF333 TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN TBC1 DOMAIN FAMILY MEMBER 25 enzyme activator activity#GO:0008047;molecular function activator activity#GO:0140677;molecular function regulator activity#GO:0098772;nucleoside-triphosphatase regulator activity#GO:0060589;GTPase activator activity#GO:0005096;GTPase regulator activity#GO:0030695;enzyme regulator activity#GO:0030234 regulation of autophagosome maturation#GO:1901096;regulation of macroautophagy#GO:0016241;regulation of catabolic process#GO:0009894;regulation of autophagy#GO:0010506;regulation of protein-containing complex disassembly#GO:0043244;regulation of metabolic process#GO:0019222;regulation of biological process#GO:0050789;regulation of organelle organization#GO:0033043;regulation of cellular component organization#GO:0051128;regulation of cellular process#GO:0050794;biological regulation#GO:0065007 intracellular anatomical structure#GO:0005622;membrane-bounded organelle#GO:0043227;autophagosome#GO:0005776;intracellular organelle#GO:0043229;cellular anatomical structure#GO:0110165;organelle#GO:0043226;intracellular membrane-bounded organelle#GO:0043231;cytoplasm#GO:0005737;vacuole#GO:0005773 GTPase-activating protein#PC00257;G-protein modulator#PC00022;protein-binding activity modulator#PC00095 HUMAN|HGNC=17262|UniProtKB=Q9HCU9 Q9HCU9 BRMS1 PTHR21964:SF15 BREAST CANCER METASTASIS-SUPPRESSOR 1 BREAST CANCER METASTASIS-SUPPRESSOR 1 histone deacetylase binding#GO:0042826;protein binding#GO:0005515;binding#GO:0005488;enzyme binding#GO:0019899 negative regulation of DNA-templated transcription#GO:0045892;regulation of DNA-templated transcription#GO:0006355;negative regulation of transcription by RNA polymerase II#GO:0000122;regulation of RNA metabolic process#GO:0051252;negative regulation of nucleobase-containing compound metabolic process#GO:0045934;negative regulation of biological process#GO:0048519;regulation of biological process#GO:0050789;regulation of macromolecule metabolic process#GO:0060255;regulation of transcription by RNA polymerase II#GO:0006357;regulation of cellular process#GO:0050794;negative regulation of metabolic process#GO:0009892;negative regulation of cellular process#GO:0048523;negative regulation of RNA metabolic process#GO:0051253;negative regulation of RNA biosynthetic process#GO:1902679;regulation of biosynthetic process#GO:0009889;regulation of gene expression#GO:0010468;negative regulation of macromolecule biosynthetic process#GO:0010558;regulation of primary metabolic process#GO:0080090;regulation of macromolecule biosynthetic process#GO:0010556;regulation of metabolic process#GO:0019222;negative regulation of macromolecule metabolic process#GO:0010605;regulation of nucleobase-containing compound metabolic process#GO:0019219;biological regulation#GO:0065007;negative regulation of biosynthetic process#GO:0009890;regulation of RNA biosynthetic process#GO:2001141 protein-containing complex#GO:0032991;intracellular membraneless organelle#GO:0043232;nuclear chromosome#GO:0000228;histone deacetylase complex#GO:0000118;membrane-enclosed lumen#GO:0031974;nucleus#GO:0005634;chromatin#GO:0000785;nuclear protein-containing complex#GO:0140513;membraneless organelle#GO:0043228;organelle#GO:0043226;nucleoplasm#GO:0005654;nuclear lumen#GO:0031981;cellular anatomical structure#GO:0110165;intracellular membrane-bounded organelle#GO:0043231;organelle lumen#GO:0043233;chromosome#GO:0005694;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;intracellular organelle lumen#GO:0070013;intracellular organelle#GO:0043229;Sin3-type complex#GO:0070822;catalytic complex#GO:1902494 HUMAN|HGNC=26799|UniProtKB=Q8N8R5 Q8N8R5 C2orf69 PTHR31296:SF1 UPF0565 PROTEIN C2ORF69 MITOCHONDRIAL PROTEIN C2ORF69 intracellular organelle#GO:0043229;membrane-bounded organelle#GO:0043227;intracellular anatomical structure#GO:0005622;mitochondrion#GO:0005739;organelle#GO:0043226;cellular anatomical structure#GO:0110165;cytoplasm#GO:0005737;intracellular membrane-bounded organelle#GO:0043231 HUMAN|HGNC=23362|UniProtKB=Q96GX8 Q96GX8 C16orf74 PTHR37455:SF1 GENE, 27021-RELATED SIMILAR TO HUMAN CHROMOSOME 16 OPEN READING FRAME 74 homeostatic process#GO:0042592;multicellular organismal-level homeostasis#GO:0048871;multicellular organismal process#GO:0032501;adaptive thermogenesis#GO:1990845;temperature homeostasis#GO:0001659 plasma membrane#GO:0005886;cellular anatomical structure#GO:0110165;cell periphery#GO:0071944;membrane#GO:0016020